LOCUS NP_009305 534 aa linear PLN 03-APR-2023 DEFINITION cytochrome c oxidase subunit 1 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009305 VERSION NP_009305.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 534) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 534) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 534) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 534) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007260. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..534 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..534 /product="cytochrome c oxidase subunit 1" /EC_number="7.1.1.9" /calculated_mol_wt="58667" Region 9..488 /region_name="Cyt_c_Oxidase_I" /note="Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cd01663" /db_xref="CDD:238833" Site order(9,91,95,97,104,145,149,167,171,191,198,201,209, 218..220,225..226,228,238,275,278,281..282,286) /site_type="other" /note="Subunit I/III interface [polypeptide binding]" /db_xref="CDD:238833" Site order(18,81,92,99,102,157..158,164,168) /site_type="active" /note="D-pathway [active]" /db_xref="CDD:238833" Site order(24,28,31,35,117..118,400,473,476) /site_type="other" /note="Subunit I/VIIc interface [polypeptide binding]" /db_xref="CDD:238833" Site order(38,41..42,408,411..412,445,463) /site_type="other" /note="Subunit I/IV interface [polypeptide binding]" /db_xref="CDD:238833" Site order(56,228,265,268..269,294..296,299,302,310,318,321, 328..330,342,360..361,363,365..369,433..434,438..440, 449..450) /site_type="other" /note="Subunit I/II interface [polypeptide binding]" /db_xref="CDD:238833" Site order(62,378,382,424,461) /site_type="other" /note="Low-spin heme (heme a) binding site [chemical binding]" /db_xref="CDD:238833" Site order(115,118) /site_type="other" /note="Subunit I/VIIa interface [polypeptide binding]" /db_xref="CDD:238833" Site order(136,214..217) /site_type="other" /note="Subunit I/VIa interface [polypeptide binding]" /db_xref="CDD:238833" Site order(191,198,238,275,278,281..282,286) /site_type="other" /note="Dimer interface" /db_xref="CDD:238833" Site order(228,233..234,364,368..369,438) /site_type="other" /note="Putative water exit pathway" /db_xref="CDD:238833" Site order(241,290..291,376) /site_type="other" /note="Binuclear center (heme a3/CuB) [ion binding]" /db_xref="CDD:238833" Site order(241,245,256,290..291,316,319) /site_type="active" /note="K-pathway [active]" /db_xref="CDD:238833" Site order(291,368..369,438..439) /site_type="other" /note="Putative proton exit pathway" /db_xref="CDD:238833" Site 296 /site_type="other" /note="Subunit I/VIb interface" /db_xref="CDD:238833" Site 329 /site_type="other" /note="Subunit I/VIc interface [polypeptide binding]" /db_xref="CDD:238833" Site order(377,438..439) /site_type="active" /note="Electron transfer pathway [active]" /db_xref="CDD:238833" Site order(409,466) /site_type="other" /note="Subunit I/VIIIb interface [polypeptide binding]" /db_xref="CDD:238833" Site order(445,449) /site_type="other" /note="Subunit I/VIIb interface [polypeptide binding]" /db_xref="CDD:238833" CDS 1..534 /gene="COX1" /locus_tag="Q0045" /gene_synonym="OXI3" /coded_by="join(NC_001224.1:13818..13986, NC_001224.1:16435..16470,NC_001224.1:18954..18991, NC_001224.1:20508..20984,NC_001224.1:21995..22246, NC_001224.1:23612..23746,NC_001224.1:25318..25342, NC_001224.1:26229..26701)" /experiment="EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:1331058|PMID:7851399]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005751 mitochondrial respiratory chain complex IV [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:9724417]" /note="Subunit I of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits; number of introns in different strains varies from 2 to 8, with most strains having 4-6 introns" /transl_table=3 /db_xref="GeneID:854598" /db_xref="SGD:S000007260" ORIGIN 1 mvqrwlystn akdiavlyfm laifsgmagt amsliirlel aapgsqylhg nsqlfnvlvv 61 ghavlmiffl vmpaliggfg nyllplmiga tdtafprinn iafwvlpmgl vclvtstlve 121 sgagtgwtvy pplssiqahs gpsvdlaifa lhltsissll gainfivttl nmrtngmtmh 181 klplfvwsif itafllllsl pvlsagitml lldrnfntsf fevsgggdpi lyehlfwffg 241 hpevyiliip gfgiishvvs tyskkpvfge ismvyamasi gllgflvwsh hmyivgldad 301 trayftsatm iiaiptgiki fswlatihgg sirlatpmly aiaflflftm ggltgvalan 361 asldvafhdt yyvvghfhyv lsmgaifslf agyyywspqi lglnynekla qiqfwlifig 421 anviffpmhf lgingmprri pdypdafagw nyvasigsfi atlslflfiy ilydqlvngl 481 nnkvnnksvi ynkapdfves ntifnlntvk sssiefllts ppavhsfntp avqs // LOCUS NP_009306 630 aa linear PLN 03-APR-2023 DEFINITION intron-encoded DNA endonuclease aI5 alpha (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009306 VERSION NP_009306.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 630) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 630) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 630) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 630) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007265. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..630 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..630 /product="intron-encoded DNA endonuclease aI5 alpha" /calculated_mol_wt="72034" Region 9..>324 /region_name="Heme_Cu_Oxidase_I" /note="Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; cl00275" /db_xref="CDD:469701" Site order(18,81,92,99,102,157..158,164,168) /site_type="active" /note="D-pathway [active]" /db_xref="CDD:238461" Site order(241,245,256,290..291,316,319) /site_type="active" /note="K-pathway [active]" /db_xref="CDD:238461" Region 424..601 /region_name="LAGLIDADG_2" /note="LAGLIDADG DNA endonuclease family; pfam03161" /db_xref="CDD:427174" CDS 1..630 /gene="AI5_ALPHA" /locus_tag="Q0070" /coded_by="join(NC_001224.1:13818..13986, NC_001224.1:16435..16470,NC_001224.1:18954..18991, NC_001224.1:20508..20984,NC_001224.1:21995..23167)" /experiment="EXISTENCE:mutant phenotype:GO:0004519 endonuclease activity [PMID:1314207]" /experiment="EXISTENCE:mutant phenotype:GO:0006316 movement of group I intron [PMID:1314207]" /note="Endonuclease I-SceIV; involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene" /transl_table=3 /db_xref="GeneID:854597" /db_xref="SGD:S000007265" ORIGIN 1 mvqrwlystn akdiavlyfm laifsgmagt amsliirlel aapgsqylhg nsqlfnvlvv 61 ghavlmiffl vmpaliggfg nyllplmiga tdtafprinn iafwvlpmgl vclvtstlve 121 sgagtgwtvy pplssiqahs gpsvdlaifa lhltsissll gainfivttl nmrtngmtmh 181 klplfvwsif itafllllsl pvlsagitml lldrnfntsf fevsgggdpi lyehlfwffg 241 hpevyiliip gfgiishvvs tyskkpvfge ismvyamasi gllgflvwsh hmyivgldad 301 trayftsatm iiaiptgiki fswlmnpfsk dknknknkkl irnyqkmnnn nmmktylnnn 361 nmimmnmykg nlydiyprsn rnyiqpnnin kelvvygynl escvgmptyt nivkhmvgip 421 nnilyimtgi lltdgwidyt skkdldkkti meincrfrlk qsmihseylm yvfmllshyc 481 msypkmkiak vkgksynqle fytrslpcft ilrymfyngr vkivpnnlyd llnyeslahm 541 imcdgsfvkg gglylnlqsf ttkelifimn ilkikfnlnc tlhksrnkyt iymrvesvkr 601 lfpmiykyil psmrykfdim lwqkkynmin // LOCUS NP_009307 556 aa linear PLN 03-APR-2023 DEFINITION intron-encoded DNA endonuclease aI4 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009307 VERSION NP_009307.2 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 556) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 556) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 556) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 556) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007264. On Jan 23, 2006 this sequence version replaced NP_009307.1. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..556 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..556 /product="intron-encoded DNA endonuclease aI4" /calculated_mol_wt="63181" Region 9..>240 /region_name="Heme_Cu_Oxidase_I" /note="Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; cl00275" /db_xref="CDD:469701" Site order(18,81,92,99,102,157..158,164,168) /site_type="active" /note="D-pathway [active]" /db_xref="CDD:238461" Region 328..415 /region_name="LAGLIDADG_1" /note="LAGLIDADG endonuclease; pfam00961" /db_xref="CDD:395767" Region 434..526 /region_name="LAGLIDADG_1" /note="LAGLIDADG endonuclease; pfam00961" /db_xref="CDD:395767" CDS 1..556 /gene="AI4" /locus_tag="Q0065" /coded_by="join(NC_001224.1:13818..13986, NC_001224.1:16435..16470,NC_001224.1:18954..18991, NC_001224.1:20508..21935)" /experiment="EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:7588637]" /experiment="EXISTENCE:direct assay:GO:0008380 RNA splicing [PMID:7588637]" /experiment="EXISTENCE:mutant phenotype:GO:0006314 intron homing [PMID:2536592]" /note="Endonuclease I-SceII; encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity" /transl_table=3 /db_xref="GeneID:854596" /db_xref="SGD:S000007264" ORIGIN 1 mvqrwlystn akdiavlyfm laifsgmagt amsliirlel aapgsqylhg nsqlfnvlvv 61 ghavlmiffl vmpaliggfg nyllplmiga tdtafprinn iafwvlpmgl vclvtstlve 121 sgagtgwtvy pplssiqahs gpsvdlaifa lhltsissll gainfivttl nmrtngmtmh 181 klplfvwsif itafllllsl pvlsagitml lldrnfntsf fevsgggdpi lyehlfwffg 241 qtvatiimlm myndmhfskc wkllkkwitn imstlfkalf vkmfmsynnq qdkmmnntml 301 kkdnikrsse ttrkmlnnsm nkkfnqwlag lidgdgyfgi vskkyvslei tvaledemal 361 keiqnkfggs iklrsgvkai ryrltnktgm iklinavngn irntkrlvqf nkvcillgid 421 fiypikltkd nswfvgffda dgtinysfkn nhpqltisvt nkylqdvqey knilggniyf 481 dksqngyykw siqskdmvln findyikmnp srttkmnkly lskefynlke lkaynkssds 541 mqykawlnfe nkwknk // LOCUS NP_009308 415 aa linear PLN 03-APR-2023 DEFINITION intron-encoded DNA endonuclease aI3 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009308 VERSION NP_009308.2 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 415) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 415) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 415) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 415) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007263. On Jan 23, 2006 this sequence version replaced NP_009308.1. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..415 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..415 /product="intron-encoded DNA endonuclease aI3" /calculated_mol_wt="47786" Region 9..>81 /region_name="Heme_Cu_Oxidase_I" /note="Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; cl00275" /db_xref="CDD:469701" Region 113..209 /region_name="LAGLIDADG_1" /note="LAGLIDADG endonuclease; pfam00961" /db_xref="CDD:395767" Region 245..367 /region_name="LAGLIDADG_1" /note="LAGLIDADG endonuclease; pfam00961" /db_xref="CDD:395767" CDS 1..415 /gene="AI3" /locus_tag="Q0060" /coded_by="join(NC_001224.1:13818..13986, NC_001224.1:16435..16470,NC_001224.1:18954..19996)" /experiment="EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:7797552]" /note="Endonuclease I-SceIII; encoded by a mobile group I intron within the mitochondrial COX1 gene" /transl_table=3 /db_xref="GeneID:854595" /db_xref="SGD:S000007263" ORIGIN 1 mvqrwlystn akdiavlyfm laifsgmagt amsliirlel aapgsqylhg nsqlfnvlvv 61 ghavlmiffl vmpaliggfg nqkryesnnn nnqvmenkey nlklnydklg pylagliegd 121 gtitvqnsss mkkskyrpli vvvfkledle lanylcnltk cgkvykkinr nyvlwtihdl 181 kgvytllnii ngymrtpkye afvrgaefmn nyinsttith nklknmdnik ikpldtsdig 241 snawlagmtd adgnfsinlm ngknrssram pyyclelrqn yqknsnnnni nfsyfyimsa 301 iatyfnvnly srernlnllv stnntyktyy sykvmvanty knikvmeyfn kysllsskhl 361 dfldwsklvi linnegqsmk tngswelgmn lrkdynktrt tftwshlknt ylenk // LOCUS NP_009309 854 aa linear PLN 03-APR-2023 DEFINITION intron-encoded reverse transcriptase aI2 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009309 VERSION NP_009309.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 854) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 854) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 854) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 854) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007262. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..854 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..854 /product="intron-encoded reverse transcriptase aI2" /calculated_mol_wt="97878" Region 3..>68 /region_name="Heme_Cu_Oxidase_I" /note="Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; cl00275" /db_xref="CDD:469701" Region 344..613 /region_name="RT_G2_intron" /note="Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable element with...; cd01651" /db_xref="CDD:238828" Site order(418..423,472..473,558,560..561,609..610) /site_type="active" /note="putative active site [active]" /db_xref="CDD:238828" Site order(418..423,472,560) /site_type="other" /note="putative NTP binding site [chemical binding]" /db_xref="CDD:238828" Site 473 /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:238828" Region 638..781 /region_name="Intron_maturas2" /note="Type II intron maturase; pfam01348" /db_xref="CDD:279664" CDS 1..854 /gene="AI2" /locus_tag="Q0055" /coded_by="join(NC_001224.1:13818..13986, NC_001224.1:16435..18830)" /experiment="EXISTENCE:direct assay:GO:0003964 RNA-directed DNA polymerase activity [PMID:7681727]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:7681727]" /experiment="EXISTENCE:mutant phenotype:GO:0006314 intron homing [PMID:14612420]" /note="Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene" /transl_table=3 /db_xref="GeneID:854594" /db_xref="SGD:S000007262" ORIGIN 1 mvqrwlystn akdiavlyfm laifsgmagt amsliirlel aapgsqylhg nsqlfnvlvv 61 ghavlmifca pfrliyhcie vlidkhisvy sinenftvsf wfwllvvtym vfryvnhmay 121 pvganstgtm achksagvkq paqgkncpma rltnsckecl gfsltpshlg ivihayvlee 181 evheltknes lalskswhle gctssngklr ntglsergnp gdngvfmvpk fnlnkvryfs 241 tlsklnarke dslayltkin ttdfselnkl mennhnktet intrilklms dirmlliayn 301 kikskkgnms kgsnnitldg inisylnkls kdintnmfkf spvrrveipk tsggfrplsv 361 gnprekivqe smrmmleiiy nnsfsyyshg frpnlsclta iiqcknymqy cnwfikvdln 421 kcfdtiphnm linvlnerik dkgfmdllyk llragyvdkn nnyhnttlgi pqgsvvspil 481 cnifldkldk ylenkfenef ntgnmsnrgr npiynslssk iyrckllsek lklirlrdhy 541 qrnmgsdksf krayfvryad diiigvmgsh ndcknilndi nnflkenlgm sinmdksvik 601 hskegvsflg ydvkvtpwek rpyrmikkgd nfirvrhhts lvvnapirsi vmklnkhgyc 661 shgilgkprg vgrliheemk tilmhylavg rgimnyyrla tnfttlrgri tyilfysccl 721 tlarkfklnt vkkvilkfgk vlvdphskvs fsiddfkirh kmnmtdsnyt pdeildryky 781 mlprslslfs gicqicgskh dlevhhvrtl nnaankikdd yllgrmikmn rkqiticktc 841 hfkvhqgkyn gpgl // LOCUS NP_009310 834 aa linear PLN 03-APR-2023 DEFINITION intron-encoded reverse transcriptase aI1 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009310 VERSION NP_009310.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 834) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 834) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 834) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 834) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007261. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..834 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..834 /product="intron-encoded reverse transcriptase aI1" /calculated_mol_wt="95948" Region 3..>56 /region_name="Heme_Cu_Oxidase_I" /note="Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; cl00275" /db_xref="CDD:469701" Region 311..577 /region_name="RT_G2_intron" /note="Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable element with...; cd01651" /db_xref="CDD:238828" Site order(385..390,439..440,522,524..525,573..574) /site_type="active" /note="putative active site [active]" /db_xref="CDD:238828" Site order(385..390,439,524) /site_type="other" /note="putative NTP binding site [chemical binding]" /db_xref="CDD:238828" Site 440 /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:238828" Region 602..759 /region_name="Intron_maturas2" /note="Type II intron maturase; pfam01348" /db_xref="CDD:279664" Region <771..823 /region_name="HNHc" /note="HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; cd00085" /db_xref="CDD:238038" Site order(781,783..785,787,808..809,815..816,819,823) /site_type="active" /db_xref="CDD:238038" CDS 1..834 /gene="AI1" /locus_tag="Q0050" /coded_by="NC_001224.1:13818..16322" /experiment="EXISTENCE:direct assay:GO:0006315 homing of group II introns [PMID:11687644]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11687644]" /experiment="EXISTENCE:mutant phenotype:GO:0003964 RNA-directed DNA polymerase activity [PMID:15925309]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:15925309]" /experiment="EXISTENCE:mutant phenotype:GO:0006278 RNA-templated DNA biosynthetic process [PMID:15925309]" /note="Reverse transcriptase required for splicing of the COX1 pre-mRNA; encoded by a mobile group II intron within the mitochondrial COX1 gene" /transl_table=3 /db_xref="GeneID:854593" /db_xref="SGD:S000007261" ORIGIN 1 mvqrwlystn akdiavlyfm laifsgmagt amsliirlel aapgsqylhg nsqlfngapt 61 sayislmrta lvlwiinryl khmtnsvgan ftgtmachkt pmisvggvkc ymvrltnflq 121 vfiritissy hldmvkqvwl fyvevirlwf ivldstgsvk kmkdtnntkg ntksegster 181 gnsgvdrgmv vpntqmkmrf lnqvryysvn nnlkmgkdtn ielskdtsts dllefeklvm 241 dnmneenmnn nllsimknvd mlmlaynrik skpgnmtpgt tletldgmnm mylnklsnel 301 gtgkfkfkpm rmvnipkpkg gmrplsvgnp rdkivqevmr mildtifdkk msthshgfrk 361 nmscqtaiwe vrnmfggsnw fievdlkkcf dtishdliik elkryisdkg fidlvykllr 421 agyidekgty hkpmlglpqg slispilcni vmtlvdnwle dyinlynkgk vkkqhptykk 481 lsrmiakakm fstrlklhke rakgptfiyn dpnfkrmkyv ryaddiligv lgskndckmi 541 krdlnnflns lgltmneekt litcatetpa rflgynisit plkrmptvtk tirgktirsr 601 nttrpiinap irdiinklat ngyckhnkng rmgvptrvgr wtyeeprtii nnykalgrgi 661 lnyyklatny krlreriyyv lyyscvltla skyrlktmsk tikkfgynln iiendklian 721 fprntfdnik kienhgmfmy mseakvtdpf eyidsikyml ptakanfnkp csicnstidv 781 emhhvkqlhr gmlkatkdyi tgrmitmnrk qiplckqchi kthknkfknm gpgm // LOCUS NP_009311 354 aa linear PLN 03-APR-2023 DEFINITION intron-encoded DNA endonuclease aI5 beta (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009311 VERSION NP_009311.2 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 354) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 354) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 354) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 354) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007266. On Nov 12, 1999 this sequence version replaced NP_009311.1. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..354 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..354 /product="intron-encoded DNA endonuclease aI5 beta" /calculated_mol_wt="42148" Region 201..300 /region_name="LAGLIDADG_1" /note="LAGLIDADG endonuclease; pfam00961" /db_xref="CDD:395767" CDS 1..354 /gene="AI5_BETA" /locus_tag="Q0075" /coded_by="join(NC_001224.1:24156..24870, NC_001224.1:24906..25255)" /note="hypothetical protein; encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG" /transl_table=3 /db_xref="GeneID:854599" /db_xref="SGD:S000007266" ORIGIN 1 mlmllmmilt nnkvfmetly yylmfnfqlm spfgvpvpgp apetkdiknl yesimnnyin 61 ilnkytinin kdninklkfl dnyteeekgy ylsglfegdg niytrcfsit fsledvllan 121 ylctyfkigh itakynfnke ltavkwnimk kkeqevfmny ingklltykr ydqyfkynfn 181 nrlnikllkp kefdltlnpw ltgfndadgy fytgfqkhkn sqwlkfhlel sqkdsyildi 241 ikkyfktggi lkrdyksgat ayiykaqssk amkpfieyfn nyqplstrry kqylllniay 301 llklnklhml tnsllmlkel mllqsvknms lemknelnnr vkiiinkthy nnie // LOCUS NP_009312 48 aa linear PLN 03-APR-2023 DEFINITION F1F0 ATP synthase subunit 8 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009312 VERSION NP_009312.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 48) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 48) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 48) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 48) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007267. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..48 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..48 /product="F1F0 ATP synthase subunit 8" /calculated_mol_wt="5691" Region 1..48 /region_name="Fun_ATP-synt_8" /note="Fungal ATP synthase protein 8 (A6L); pfam05933" /db_xref="CDD:283561" CDS 1..48 /gene="ATP8" /locus_tag="Q0080" /gene_synonym="AAP1" /coded_by="NC_001224.1:27666..27812" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015986 proton movtive force-driven ATP synthesis[PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [PMID:8662204]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis[PMID:8662204]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:8662204]" /note="Subunit 8 of the F0 sector of mitochondrial F1F0 ATP synthase; encoded on the mitochondrial genome; ATP8 and ATP6 mRNAs are not translated in the absence of the F1 sector of ATPase" /transl_table=3 /db_xref="GeneID:854600" /db_xref="SGD:S000007267" ORIGIN 1 mpqlvpfyfm nqltygfllm itllilfsqf flpmilrlyv srlfiskl // LOCUS NP_009313 259 aa linear PLN 03-APR-2023 DEFINITION F1F0 ATP synthase subunit a (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009313 VERSION NP_009313.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 259) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 259) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 259) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 259) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007268. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..259 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..259 /product="F1F0 ATP synthase subunit a" /calculated_mol_wt="28968" Region 30..256 /region_name="ATP_synt_6_or_A" /note="ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); TIGR01131" /db_xref="CDD:273458" CDS 1..259 /gene="ATP6" /locus_tag="Q0085" /gene_synonym="OLI2; OLI4; PHO1" /coded_by="NC_001224.1:28487..29266" /experiment="EXISTENCE:direct assay:GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis[PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis[PMID:17940284|PMID:6251866]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:17940284|PMID:6251866]" /note="Subunit a of the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrially encoded; translation is specifically activated by Atp22p; ATP6 and ATP8 mRNAs are not translated in the absence of the F1 sector of ATPase; mutations in human ortholog MT-ATP6 are associated with neurodegenerative disorders such as Neurogenic Ataxia and Retinitis Pigmentosa (NARP), Leigh syndrome (LS), Charcot-Marie-Tooth (CMT), and ataxia telangiectasia" /transl_table=3 /db_xref="GeneID:854601" /db_xref="SGD:S000007268" ORIGIN 1 mfnllntyit spldqfeirt lfglqssfid lsclnlttfs lytiivllvi tslytltnnn 61 nkiigsrwli sqeaiydtim nmtkgqiggk nwglyfpmif tlfmfifian lismipysfa 121 lsahlvfiis lsiviwlgnt ilglykhgwv ffslfvpagt plplvpllvi ietlsyfara 181 islglrlgsn ilaghllmvi lagltfnfml inlftlvfgf vplamilaim mlefaigiiq 241 gyvwailtas ylkdavylh // LOCUS NP_009315 385 aa linear PLN 03-APR-2023 DEFINITION cytochrome b (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009315 VERSION NP_009315.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 385) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 385) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 385) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007270. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..385 /product="cytochrome b" /EC_number="7.1.1.8" /calculated_mol_wt="43525" Region 10..366 /region_name="CYTB" /note="cytochrome b; Provisional; MTH00156" /db_xref="CDD:214440" CDS 1..385 /gene="COB" /locus_tag="Q0105" /gene_synonym="COB1; CYTB" /coded_by="join(NC_001224.1:36540..36954, NC_001224.1:37723..37736,NC_001224.1:39141..39217, NC_001224.1:40841..41090,NC_001224.1:42508..42558, NC_001224.1:43297..43647)" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005750 mitochondrial respiratory chain complex III [PMID:10873857|PMID:391561]" /experiment="EXISTENCE:direct assay:GO:0008121 ubiquinol-cytochrome-c reductase activity [PMID:391561]" /experiment="EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:391561]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:391561]" /note="Cytochrome b; mitochondrially-encoded subunit of ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p; number of introns varies between strains from 0 to 6, with most having 5" /transl_table=3 /db_xref="GeneID:854583" /db_xref="SGD:S000007270" ORIGIN 1 mafrksnvyl slvnsyiids pqpssinyww nmgsllglcl viqivtgifm amhyssniel 61 afssvehimr dvhngyilry lhangasfff mvmfmhmakg lyygsyrspr vtlwnvgvii 121 filtiatafl gyccvygqms hwgatvitnl fsaipfvgnd ivswlwggfs vsnptiqrff 181 alhylvpfii aamvimhlma lhihgssnpl gitgnldrip mhsyfifkdl vtvflfmlil 241 alfvfyspnt lghpdnyipg nplvtpasiv pewyllpfya ilrsipdkll gvitmfaail 301 vllvlpftdr svvrgntfkv lskffffifv fnfvllgqig achvevpyvl mgqiatfiyf 361 ayfliivpvi stienvlfyi grvnk // LOCUS NP_009316 638 aa linear PLN 03-APR-2023 DEFINITION intron-encoded RNA maturase bI4 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009316 VERSION NP_009316.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 638) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 638) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 638) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 638) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007273. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..638 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..638 /product="intron-encoded RNA maturase bI4" /calculated_mol_wt="74449" Region 10..>252 /region_name="CYTB" /note="cytochrome b; Provisional; MTH00156" /db_xref="CDD:214440" Region 408..495 /region_name="LAGLIDADG_1" /note="LAGLIDADG endonuclease; pfam00961" /db_xref="CDD:395767" CDS 1..638 /gene="BI4" /locus_tag="Q0120" /coded_by="join(NC_001224.1:36540..36954, NC_001224.1:37723..37736,NC_001224.1:39141..39217, NC_001224.1:40841..42251)" /experiment="EXISTENCE:direct assay:GO:0000372 Group I intron splicing [PMID:11142386]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:11142386]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:2875797]" /experiment="EXISTENCE:mutant phenotype:GO:0000372 Group I intron splicing [PMID:11142386]" /experiment="EXISTENCE:mutant phenotype:GO:0090615 mitochondrial mRNA processing [PMID:8917309]" /note="Mitochondrial mRNA maturase; forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA" /transl_table=3 /db_xref="GeneID:854582" /db_xref="SGD:S000007273" ORIGIN 1 mafrksnvyl slvnsyiids pqpssinyww nmgsllglcl viqivtgifm amhyssniel 61 afssvehimr dvhngyilry lhangasfff mvmfmhmakg lyygsyrspr vtlwnvgvii 121 filtiatafl gyccvygqms hwgatvitnl fsaipfvgnd ivswlwggfs vsnptiqrff 181 alhylvpfii aamvimhlma lhihgssnpl gitgnldrip mhsyfifkdl vtvflfmlil 241 alfvfyspnt lgqnmallli tyvinilcav cwkslfikyq wkiynkttyy fiiqnilntk 301 qlnnfvlkfn wtkqynkmni vsdlfnpnrv kyyykednqq vtnmnssnth ltsnkknllv 361 dtsettrttk nkfnyllnif nmkkmnqiit krhysiykds nirfnqwlag lidgdgyfci 421 tknkyascei tvelkdekml rqiqdkfggs vklrsgvkai ryrlqnkegm iklinavngn 481 irnskrlvqf nkvcillnid fkepikltkd nawfmgffda dgtinyyysg klkirpqlti 541 svtnkylhdv eyyrevfggn iyfdkakngy fkwsinnkel hnifytynks cpsksnkgkr 601 lflidkfyyl ydllafkaph ntalykawlk fnekwnnn // LOCUS NP_009317 517 aa linear PLN 03-APR-2023 DEFINITION cytochrome b mRNA maturase bI3 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009317 VERSION NP_009317.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 517) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 517) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 517) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 517) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007272. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..517 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..517 /product="cytochrome b mRNA maturase bI3" /calculated_mol_wt="61041" Region 3..>174 /region_name="CYTB" /note="cytochrome b; Provisional; MTH00191" /db_xref="CDD:177239" Region 270..367 /region_name="LAGLIDADG_1" /note="LAGLIDADG endonuclease; pfam00961" /db_xref="CDD:395767" Region 405..499 /region_name="LAGLIDADG_1" /note="LAGLIDADG endonuclease; pfam00961" /db_xref="CDD:395767" CDS 1..517 /gene="BI3" /locus_tag="Q0115" /coded_by="join(NC_001224.1:36540..36954, NC_001224.1:37723..37736,NC_001224.1:39141..40265)" /experiment="EXISTENCE:curator inference:GO:0005739 mitochondrion [PMID:2538624]" /experiment="EXISTENCE:direct assay:GO:0000372 Group I intron splicing [PMID:11773622]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:11773622]" /experiment="EXISTENCE:direct assay:GO:0090615 mitochondrial mRNA processing [PMID:11773622]" /experiment="EXISTENCE:mutant phenotype:GO:0090615 mitochondrial mRNA processing [PMID:2538624]" /note="Mitochondrial mRNA maturase; forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA" /transl_table=3 /db_xref="GeneID:854605" /db_xref="SGD:S000007272" ORIGIN 1 mafrksnvyl slvnsyiids pqpssinyww nmgsllglcl viqivtgifm amhyssniel 61 afssvehimr dvhngyilry lhangasfff mvmfmhmakg lyygsyrspr vtlwnvgvii 121 filtiatafl gyccvygqms hwgatvitnl fsaipfvgnd ivswlwggfn medpyysnmm 181 lnksvlcwni fiwmmnyyii qliiynnmiw nknnmvkmfi mrrklavinm ymymkliiqr 241 tysyymnnti iydknhklnt dnpiyayigg lfegdgwiti skkgkyllye lgiemhirdi 301 qllykiknil gigkvtikkl kmkdgtikem ckfnvrnknh lkniiipifd kypmltnkhy 361 dylyfkdnll kdikyyndls yylrpikpfn ttedilnkny fsswligffe aescfsiykp 421 mnkkmktasf evsqnnsmev mlaiksylki tqniytdkfn nsrmttksin giknvvmfin 481 nnpikllgyk klqyllflkd lrtitkynny fkippky // LOCUS NP_009318 423 aa linear PLN 03-APR-2023 DEFINITION cytochrome b mRNA maturase bI2 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009318 VERSION NP_009318.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 423) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 423) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 423) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007271. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..423 /product="cytochrome b mRNA maturase bI2" /calculated_mol_wt="49196" Region 3..>143 /region_name="CYTB" /note="cytochrome b; Provisional; MTH00191" /db_xref="CDD:177239" Region 223..403 /region_name="LAGLIDADG_2" /note="LAGLIDADG DNA endonuclease family; pfam03161" /db_xref="CDD:427174" CDS 1..423 /gene="BI2" /locus_tag="Q0110" /coded_by="join(NC_001224.1:36540..36954, NC_001224.1:37723..38579)" /experiment="EXISTENCE:direct assay:GO:0004518 nuclease activity [PMID:8670880]" /experiment="EXISTENCE:direct assay:GO:0008380 RNA splicing [PMID:8670880]" /note="Mitochondrial mRNA maturase with a role in splicing; encoded by both exon and intron sequences of partially processed COB mRNA" /transl_table=3 /db_xref="GeneID:854604" /db_xref="SGD:S000007271" ORIGIN 1 mafrksnvyl slvnsyiids pqpssinyww nmgsllglcl viqivtgifm amhyssniel 61 afssvehimr dvhngyilry lhangasfff mvmfmhmakg lyygsyrspr vtlwnvgvii 121 filtiatafl gyccvygqms hwgnmniasn mfnmmktiym mmlmlliyif ytimmrqmmk 181 tkeytmliks mdyinknkym inlnmtnkkd mnnnigplnm nilsiiygsm lgdghaekrk 241 ggkgtrivfq qeycninyly ylhsllanlg ycntnlplik trlgkkgkir qylkfntwty 301 dsfnmiysew yiknmsgkgn ikvipksldn yltplalaiw imddgcklgk glkfttncfs 361 ykdvqyltyl lhnkynikst itkgnkentq fviyvwkesm piltkivspy iipsmkyklg 421 nyl // LOCUS NP_009319 76 aa linear PLN 03-APR-2023 DEFINITION F0 ATP synthase subunit c (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009319 VERSION NP_009319.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 76) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 76) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 76) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 76) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007274. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..76 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..76 /product="F0 ATP synthase subunit c" /calculated_mol_wt="7628" Region 8..72 /region_name="ATP-synt_Fo_c_ATP5G3" /note="ATP synthase F(0) complex subunit C3 (ATP5G3) and similar proteins; cd18182" /db_xref="CDD:349422" CDS 1..76 /gene="OLI1" /locus_tag="Q0130" /gene_synonym="ATP9; OLI3" /coded_by="NC_001224.1:46723..46953" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis[PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0016887 ATPase activity [PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:physical interaction:GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [PMID:2894987]" /note="F0-ATP synthase subunit c (ATPase-associated proteolipid); encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2" /transl_table=3 /db_xref="GeneID:854584" /db_xref="SGD:S000007274" ORIGIN 1 mqlvlaakyi gagistigll gagigiaivf aalingvsrn psikdtvfpm ailgfalsea 61 tglfclmvsf lllfgv // LOCUS NP_009320 398 aa linear PLN 03-APR-2023 DEFINITION mitochondrial 37S ribosomal protein VAR1 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009320 VERSION NP_009320.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 398) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 398) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 398) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 398) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007275. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..398 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..398 /product="mitochondrial 37S ribosomal protein VAR1" /calculated_mol_wt="46992" Region 135..398 /region_name="VAR1" /note="Mitochondrial ribosomal protein (VAR1); pfam05316" /db_xref="CDD:461621" CDS 1..398 /gene="VAR1" /locus_tag="Q0140" /gene_synonym="uS3m" /coded_by="NC_001224.1:48901..50097" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005761 mitochondrial ribosome [PMID:387793]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:24186543|PMID:6250484]" /note="Mitochondrial ribosomal protein of the small subunit; mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane; may have a role in loss of mitochondrial DNA under stress conditions" /transl_table=3 /db_xref="GeneID:854586" /db_xref="SGD:S000007275" ORIGIN 1 mklkllnmil smmnktnnnn niiinntlds lmnkklllkn mlldmnnkkm nnmkrmlnnn 61 nmnpaganpv vhrigpagni nnklqhlnnm nnwntqiyny nknmeimntm ndklinklly 121 kmmtlklnnm ninkiimskt inqhslnkln ikfyyynndi nnnnnnnnnn yymnmmnklm 181 nimnnnmnnn lcnilsyyyk kkvtiepikl syiylnsdif skyislndmd kynngiltny 241 qrmlnnimpk lndhnismny inninninnn kynnminlln nnnninnnnn ynnnnnnyig 301 ninniynnmt idnipmdilm ykylvgwsik fkgrlsnnng rtsttnllng tfnnkkylws 361 ninnnyklny ipsnhnlynn sninkngkyn ikvklnfi // LOCUS NP_009324 235 aa linear PLN 03-APR-2023 DEFINITION intron-encoded endonuclease I-SceI (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009324 VERSION NP_009324.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 235) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 235) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 235) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007279. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..235 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..235 /product="intron-encoded endonuclease I-SceI" /calculated_mol_wt="27552" Region 34..208 /region_name="LAGLIDADG_2" /note="LAGLIDADG DNA endonuclease family; pfam03161" /db_xref="CDD:427174" CDS 1..235 /gene="SCEI" /locus_tag="Q0160" /coded_by="NC_001224.1:61022..61729" /experiment="EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:16478204|PMID:8335007]" /note="I-SceI DNA endonuclease; encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene" /transl_table=3 /db_xref="GeneID:854590" /db_xref="SGD:S000007279" ORIGIN 1 mknikknqvm nlgpnskllk eyksqlieln ieqfeagigl ilgdayirsr degktycmqf 61 ewknkaymdh vcllydqwvl spphkkervn hlgnlvitwg aqtfkhqafn klanlfivnn 121 kktipnnlve nyltpmslay wfmddggkwd ynknstnksi vlntqsftfe eveylvkglr 181 nkfqlncyvk inknkpiiyi dsmsylifyn likpylipqm myklpntiss etflk // LOCUS NP_009326 251 aa linear PLN 03-APR-2023 DEFINITION cytochrome c oxidase subunit 2 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009326 VERSION NP_009326.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 251) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 251) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 251) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 251) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007281. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..251 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..251 /product="cytochrome c oxidase subunit 2" /EC_number="7.1.1.9" /calculated_mol_wt="28436" Region 24..249 /region_name="COX2" /note="cytochrome c oxidase subunit II; Provisional; MTH00154" /db_xref="CDD:214438" CDS 1..251 /gene="COX2" /locus_tag="Q0250" /gene_synonym="OXI1; OXII" /coded_by="NC_001224.1:73758..74513" /experiment="EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:1331058|PMID:7851399]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005751 mitochondrial respiratory chain complex IV [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:224191]" /note="Subunit II of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits" /transl_table=3 /db_xref="GeneID:854622" /db_xref="SGD:S000007281" ORIGIN 1 mldllrlqlt tfimndvptp yacyfqdsat pnqegilelh dnimfyllvi lglvswmlyt 61 ivmtysknpi aykyikhgqt ieviwtifpa villiiafps fillylcdev ispamtikai 121 gyqwywkyey sdfindsget vefesyvipd elleegqlrl ldtdtsmvvp vdthirfvvt 181 aadvihdfai pslgikvdat pgrlnqvsal iqregvfyga cselcgtgha nmpikieavs 241 lpkflewlne q // LOCUS NP_009327 472 aa linear PLN 03-APR-2023 DEFINITION maturase-like protein (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009327 VERSION NP_009327.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 472) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 472) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 472) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 472) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007282. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..472 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..472 /product="maturase-like protein" /calculated_mol_wt="56282" Region 89..183 /region_name="LAGLIDADG_1" /note="LAGLIDADG endonuclease; pfam00961" /db_xref="CDD:395767" Region 417..469 /region_name="IENR1" /note="Intron encoded nuclease repeat motif; smart00497" /db_xref="CDD:197761" CDS 1..472 /locus_tag="Q0255" /coded_by="join(NC_001224.1:74495..75622, NC_001224.1:75663..75872,NC_001224.1:75904..75984)" /note="Maturase-like protein" /transl_table=3 /db_xref="GeneID:854623" /db_xref="SGD:S000007282" ORIGIN 1 mikwtminiy lllmfliikn nnnnnnynni tkynkdmdly siqspyiknm niikrgyhts 61 lnnkliivqk dnknnnknnl emdnfykwlv gftdgdgsfy iklndkkylr ffygfrmhid 121 dkaclekirn mlnmpsnfee ttktimlvns qkkwlysniv tifdkypclt ikyysyykwk 181 maminnlngm synnkdllni kntinnyevm pnlkipydkm ndywilgfie aegsfdtspk 241 rnicgfnvsq hkrsintlka iksyvlnnwk pidntpllik nkllkdwdss ikltkpdkng 301 viklefnrmd flyyvilpkl yslkwysrke idfqlwkttm eiymkglhnt tkgsnllkli 361 nnninkkryy snynisknii ddvlnmntiy nyklpyrmns diqrlnsmnn nntkfinvgv 421 fvydlnntli mtftgyrpaa tyfncskhei akyikngnvf mnkyilknil ld // LOCUS NP_009328 269 aa linear PLN 03-APR-2023 DEFINITION cytochrome c oxidase subunit 3 (mitochondrion) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009328 VERSION NP_009328.1 DBLINK BioProject: PRJNA927338 KEYWORDS RefSeq. SOURCE mitochondrion Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NC_001224.1 REFERENCE 1 (residues 1 to 269) AUTHORS Foury,F., Roganti,T., Lecrenier,N. and Purnelle,B. TITLE The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae JOURNAL FEBS Lett. 440 (3), 325-331 (1998) PUBMED 9872396 REFERENCE 2 (residues 1 to 269) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (14-JAN-2015) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 3 (residues 1 to 269) CONSRTM The Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-DEC-2014) Genetics, Saccharomyces Genome Database, Stanford University, Stanford, CA 94305, USA REFERENCE 4 (residues 1 to 269) CONSRTM MIPS TITLE Direct Submission JOURNAL Submitted (16-DEC-1998) Max-Planck-Institut fuer Biochemie, Am Klopferspitz 18a D-82152 Martinsried, Germany COMMENT PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence is identical to S000007283. COMPLETENESS: full length. FEATURES Location/Qualifiers source 1..269 /organism="Saccharomyces cerevisiae S288C" /organelle="mitochondrion" /strain="S288C" /sub_strain="FY1679" /db_xref="taxon:559292" Protein 1..269 /product="cytochrome c oxidase subunit 3" /EC_number="7.1.1.9" /calculated_mol_wt="30229" Region 12..269 /region_name="COX3" /note="Cytochrome c oxidase subunit III; pfam00510" /db_xref="CDD:395410" Site order(64,67..68,71,74..76) /site_type="other" /note="Subunit III/VIIa interface [polypeptide binding]" /db_xref="CDD:238834" Site order(65..66,69..70,73,79,90..91,94,222,229,241..242) /site_type="other" /note="Phospholipid binding site [chemical binding]" /db_xref="CDD:238834" Site order(82,85..86,97,100,104..105,111,199..200,203,207) /site_type="other" /note="Subunit I/III interface [polypeptide binding]" /db_xref="CDD:238834" Site 127 /site_type="other" /note="Subunit III/VIb interface [polypeptide binding]" /db_xref="CDD:238834" Site order(135..137,154,180,190..192,197..199) /site_type="other" /note="Subunit III/VIa interface" /db_xref="CDD:238834" Site 166 /site_type="other" /note="Subunit III/Vb interface [polypeptide binding]" /db_xref="CDD:238834" CDS 1..269 /gene="COX3" /locus_tag="Q0275" /gene_synonym="OXI2" /coded_by="NC_001224.1:79213..80022" /experiment="EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:7851399|PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24478450|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005751 mitochondrial respiratory chain complex IV [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:11171120]" /note="Subunit III of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits" /transl_table=3 /db_xref="GeneID:854627" /db_xref="SGD:S000007283" ORIGIN 1 mthlersrhq qhpfhmvmps pwpivvsfal lslalstalt mhgyignmnm vylalfvllt 61 ssilwfrdiv aeatylgdht mavrkginlg flmfvlsevl ifaglfwayf hsamspdvtl 121 gacwppvgie avqptelpll ntiillssga tvtyshhali agnrnkalsg llitfwlivi 181 fvtcqyieyt naaftisdgv ygsvfyagtg lhflhmvmla amlgvnywrm rnyhltaghh 241 vgyettiiyt hvldviwlfl yvvfywwgv // LOCUS NP_009332 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009332 VERSION NP_009332.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180043.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 120) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06918. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..120 /product="seripauperin PAU8" /calculated_mol_wt="12719" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU8" /locus_tag="YAL068C" /coded_by="NM_001180043.1:1..363" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:12586695]" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions" /db_xref="GeneID:851229" /db_xref="SGD:S000002142" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ymfqaahpte 61 typvevaeav fnygdfttml tgiapdqvtr mitgvpwyss rlkpaissal skdgiytian // LOCUS NP_878038 75 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAL067W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878038 VERSION NP_878038.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184582.1 REFERENCE 1 (residues 1 to 75) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 75) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 75) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 75) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06919. Method: conceptual translation. FEATURES Location/Qualifiers source 1..75 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..75 /product="uncharacterized protein" /calculated_mol_wt="8627" CDS 1..75 /locus_tag="YAL067W-A" /coded_by="NM_001184582.1:1..228" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466426" /db_xref="SGD:S000028593" ORIGIN 1 mpiigvprcl ikpfsvpvtf pfsvkkniri ldldprteay clslnsvcfk rlprrkyfhl 61 lnsynikrvl gvvyc // LOCUS NP_009333 593 aa linear PLN 30-JUN-2025 DEFINITION putative permease SEO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009333 VERSION NP_009333.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178208.1 REFERENCE 1 (residues 1 to 593) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 593) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 593) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 593) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06920. Method: conceptual translation. FEATURES Location/Qualifiers source 1..593 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..593 /product="putative permease SEO1" /calculated_mol_wt="68711" Region 134..548 /region_name="MFS_FEN2_like" /note="Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; cd17327" /db_xref="CDD:340885" Site order(150..151,154..155,158,191,241..242,244..246,249,269, 272..273,276,381,384..385,388..390,393,421,425,475..476, 480,484,502,505..506,509..510,513) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340885" CDS 1..593 /gene="SEO1" /locus_tag="YAL067C" /coded_by="NM_001178208.1:1..1782" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:40288644]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0042938 dipeptide transport [PMID:40288644]" /experiment="EXISTENCE:genetic interaction:GO:0071916 dipeptide transmembrane transporter activity [PMID:40288644]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:8893857]" /note="High affinity dipeptide transmembrane transporter; involved in the transport of the gamma-Glu-met dipeptide across the plasma membrane; member of the allantoate transporter subfamily of the major facilitator superfamily; transcriptionally upregulated in cells grown on gamma-Glu-met; mutation confers resistance to ethionine sulfoxide" /db_xref="GeneID:851230" /db_xref="SGD:S000000062" ORIGIN 1 mysivkeiiv dpykrlkwgf ipvkrqvedl pddlnsteiv tisnsiqshe taenfittts 61 ekdqlhfets sysehkdnvn vtrsyeyrde adrpwwrffd eqeyrineke rshnkwyswf 121 kqgtsfkekk llikldvlla fysciaywvk yldtvninna yvsgmkedlg fqgndlvhtq 181 vmytvgniif qlpfliylnk lplnyvlpsl dlcwslltvg aayvnsvphl kairffigaf 241 eapsylayqy lfgsfykhde mvrrsafyyl gqyigilsag giqsavyssl ngvnglegwr 301 wnfiidaivs vvvgligfys lpgdpyncys ifltddeirl arkrlkenqt gksdfetkvf 361 diklwktifs dwkiyiltlw nifcwndsnv ssgayllwlk slkrysipkl nqlsmitpgl 421 gmvylmltgi iadklhsrwf aiiftqvfni ignsilaawd vaegakwfaf mlqcfgwama 481 pvlyswqndi crrdaqtrai tlvtmnimaq sstawisvlv wkteeapryl kgftftacsa 541 fclsiwtfvv lyfykrdern nakkngivly nskhgvekpt skdvetlsvs dek // LOCUS NP_009335 128 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAL065C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009335 VERSION NP_009335.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179897.1 REFERENCE 1 (residues 1 to 128) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 128) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 128) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 128) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06921. Method: conceptual translation. FEATURES Location/Qualifiers source 1..128 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..128 /product="uncharacterized protein" /calculated_mol_wt="12788" CDS 1..128 /locus_tag="YAL065C" /coded_by="NM_001179897.1:1..387" /note="hypothetical protein; shows sequence similarity to FLO1 and other flocculins" /db_xref="GeneID:851232" /db_xref="SGD:S000001817" ORIGIN 1 mnsatsettt ntgaaettts tgaaetktvv tssisrfnha etqtasatdv ighsssvvsv 61 setgntksli tsglstmsqq prstpassii gsstasleis tyvgiangll tnngisvfis 121 tvllaivw // LOCUS NP_009336 126 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAL064W-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_009336 VERSION NP_009336.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180042.1 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 126) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06922. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..126 /product="uncharacterized protein" /calculated_mol_wt="13142" CDS 1..126 /locus_tag="YAL064W-B" /coded_by="NM_001180042.1:1..381" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Fungal-specific hypothetical protein" /db_xref="GeneID:851233" /db_xref="SGD:S000002141" ORIGIN 1 mageavseht pdsqevtvts vvccldsvve ighhvvysvv tplivavlid tmageavleh 61 tsdsqeeivt tvvcsvvplv cfvvsvvcfv isvveighhv vysvvapltv tvavetiaee 121 mdsvht // LOCUS NP_058136 126 aa linear PLN 30-JUN-2025 DEFINITION Tda8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_058136 VERSION NP_058136.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180041.1 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 126) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06923. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..126 /product="Tda8p" /calculated_mol_wt="13754" Region <1..108 /region_name="PA14" /note="PA14 domain; cl08459" /db_xref="CDD:471833" CDS 1..126 /gene="TDA8" /locus_tag="YAL064C-A" /gene_synonym="YAL065C-A" /coded_by="NM_001180041.1:1..381" /note="hypothetical protein; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene" /db_xref="GeneID:851234" /db_xref="SGD:S000002140" ORIGIN 1 mtgyflppqt ssytfrfakv ddsailsvgg dvafgccaqe qppitstnft ingikpwqgr 61 lpdniagtvy myagfycpmk ivysnavswh tlpvsvelpd vttvsddfag hvysfdddlt 121 aqlyyp // LOCUS NP_009337 94 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAL064W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009337 VERSION NP_009337.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178206.2 REFERENCE 1 (residues 1 to 94) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 94) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 94) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 94) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06924. On Apr 26, 2011 this sequence version replaced NP_009337.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..94 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..94 /product="uncharacterized protein" /calculated_mol_wt="10873" CDS 1..94 /locus_tag="YAL064W" /coded_by="NM_001178206.2:1..285" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments" /db_xref="GeneID:851235" /db_xref="SGD:S000000060" ORIGIN 1 mnpfaslegq dnissvfflh mqqfesqvkd rfrfpifrle rktfgnscyq vetlkvkcrp 61 rhakscnllt llfksrtqsv lvpnfgflil nsep // LOCUS NP_878039 96 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAL063C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878039 VERSION NP_878039.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184642.1 REFERENCE 1 (residues 1 to 96) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 96) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 96) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 96) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06925. Method: conceptual translation. FEATURES Location/Qualifiers source 1..96 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..96 /product="uncharacterized protein" /calculated_mol_wt="11177" CDS 1..96 /locus_tag="YAL063C-A" /coded_by="NM_001184642.1:1..291" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466427" /db_xref="SGD:S000028813" ORIGIN 1 mcprtvllii ninhwfydkn ivriiltfrl dsghisdicf inknlanali tadisllkrh 61 dirctkyiit yyqryrnkek gkfislcknt iisssv // LOCUS NP_009338 1322 aa linear PLN 30-JUN-2025 DEFINITION flocculin FLO9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009338 VERSION NP_009338.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178205.1 REFERENCE 1 (residues 1 to 1322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1322) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06926. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1322 /product="flocculin FLO9" /calculated_mol_wt="137942" Region 118..249 /region_name="PA14" /note="PA14 domain; pfam07691" /db_xref="CDD:400161" Region <295..1027 /region_name="FhaB" /note="Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]; COG3210" /db_xref="CDD:442443" Region 1022..1063 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" Region 1097..1135 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" Region 1108..>1286 /region_name="Chi1" /note="Chitinase [Carbohydrate transport and metabolism]; COG3469" /db_xref="CDD:442692" Region 1143..1186 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" CDS 1..1322 /gene="FLO9" /locus_tag="YAL063C" /coded_by="NM_001178205.1:1..3969" /experiment="EXISTENCE:mutant phenotype:GO:0000128 flocculation [PMID:19420680|PMID:19087208]" /experiment="EXISTENCE:mutant phenotype:GO:0031589 cell-substrate adhesion [PMID:19087208]" /note="Lectin-like protein with similarity to Flo1p; thought to be expressed and involved in flocculation" /db_xref="GeneID:851236" /db_xref="SGD:S000000059" ORIGIN 1 mslahyclll aivtllgltn vvsattaacl pansrkngmn vnfyqyslrd sstysnaaym 61 aygyasktkl gsvggqtdis idynipcvss sgtfpcpqed lygnwgckgi gacsnnpiia 121 ywstdlfgfy ttptnvtlem tgyflppqtg sytfkfatvd dsailsvggs iafeccaqeq 181 ppitstnfti ngikpwngsp pdnitgtvym yagfyypmki vysnavawgt lpisvtlpdg 241 ttvsddfegy vytfdnnlsq pnctipdpsn ytvsttittt epwtgtftst stemttvtgt 301 ngvptdetvi virtpttast iitttepwns tftststelt tvtgtngvrt detiivirtp 361 ttattaittt epwnstftst stelttvtgt nglptdetii virtpttatt amtttqpwnd 421 tftststelt tvtgtnglpt detiivirtp ttattamttt qpwndtftst stelttvtgt 481 nglptdetii virtpttatt amtttqpwnd tftststeit tvtgtnglpt detiivirtp 541 ttattamttt qpwndtftst stemttvtgt nglptdetii virtpttatt aitttepwns 601 tftststemt tvtgtnglpt detiivirtp ttattaittt qpwndtftst stemttvtgt 661 nglptdetii virtpttatt amtttqpwnd tftststeit tvtgtnglpt detiivirtp 721 ttattamttt qpwndtftst stemttvtgt ngvptdetvi virtptsegl istttepwtg 781 tftststemt tvtgtngqpt detvivirtp tseglvtttt epwtgtftst stemttitgt 841 ngqptdetvi ivktpttais sslssssgqi tsfitsarpi itpfypsngt svisssviss 901 sdtsslviss svtsslvtss pvisssfiss pvisstttsa silsesskss viptssstsg 961 ssesetgsas sasssssiss espkstysss slppvtsatt sqeitsslpp vtttktseqt 1021 tlvtvtsces hvctesissa ivstatvtvs gatteyttwc pistteitkq ttettkqtkg 1081 tteqttettk qttvvtissc esdvcsktas paivststat ingvtteytt wcpisttesk 1141 qqttlvtvts cgsgvcsett spaivstata tvndvvtvys twrpqttneq svsskmnsat 1201 setttntgaa etttstgaae tktvvtssis rfnhaetqta satdvighss svvsvsetgn 1261 tksltssgls tmsqqprstp assmvgssta sleistyags ansllagsgl svfiasllla 1321 ii // LOCUS NP_009339 457 aa linear PLN 30-JUN-2025 DEFINITION glutamate dehydrogenase (NADP(+)) GDH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009339 VERSION NP_009339.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178204.1 REFERENCE 1 (residues 1 to 457) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 457) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 457) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 457) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06927. Method: conceptual translation. FEATURES Location/Qualifiers source 1..457 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..457 /product="glutamate dehydrogenase (NADP(+)) GDH3" /EC_number="1.4.1.4" /calculated_mol_wt="49496" Region 4..454 /region_name="PRK09414" /note="NADP-specific glutamate dehydrogenase" /db_xref="CDD:181834" CDS 1..457 /gene="GDH3" /locus_tag="YAL062W" /gene_synonym="FUN51" /coded_by="NM_001178204.1:1..1374" /experiment="EXISTENCE:direct assay:GO:0004354 glutamate dehydrogenase (NADP+) activity [PMID:11562373]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:4126]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0004354 glutamate dehydrogenase (NADP+) activity [PMID:9287019]" /experiment="EXISTENCE:mutant phenotype:GO:0006537 glutamate biosynthetic process [PMID:9287019]" /note="NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication" /db_xref="GeneID:851237" /db_xref="SGD:S000000058" ORIGIN 1 mtsepefqqa ydeivssved skifekfpqy kkvlpivsvp eriiqfrvtw endngeqeva 61 qgyrvqfnsa kgpykgglrf hpsvnlsilk flgfeqifkn altgldmggg kgglcvdlkg 121 ksdneirric yafmrelsrh igkdtdvpag digvggreig ylfgayrsyk nswegvltgk 181 glnwggslir peatgfglvy ytqamidyat ngkesfegkr vtisgsgnva qyaalkviel 241 ggivvslsds kgciisetgi tseqihdias akirfkslee ivdeystfse skmkyvagar 301 pwthvsnvdi alpcatqnev sgdeakalva sgvkfvaega nmgstpeais vfetarstat 361 nakdavwfgp pkaanlggva vsglemaqns qkvtwtaerv dqelkkimin cfndciqaaq 421 eystekntnt lpslvkgani asfvmvadam ldqgdvf // LOCUS NP_009340 417 aa linear PLN 30-JUN-2025 DEFINITION putative dehydrogenase BDH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009340 VERSION NP_009340.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178203.1 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 417) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06928. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..417 /product="putative dehydrogenase BDH2" /EC_number="1.1.1.303" /calculated_mol_wt="45968" Region 1..375 /region_name="butanediol_DH_like" /note="(2R,3R)-2,3-butanediol dehydrogenase; cd08233" /db_xref="CDD:176195" Site order(39..41,44,173,177,197..202,221..222,226,240,268..269, 271,294..295,316..318) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:176195" Site order(39,41,73,173) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176195" CDS 1..417 /gene="BDH2" /locus_tag="YAL061W" /coded_by="NM_001178203.1:1..1254" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3" /db_xref="GeneID:851238" /db_xref="SGD:S000000057" ORIGIN 1 mralayfgkg nirftnhlke phivapdelv idiewcgicg tdlheytdgp iffpedghth 61 eishnplpqa mghemagtvl evgpgvknlk vgdkvvvept gtcrdryrwp lspnvdkewc 121 aackkgyyni csylglcgag vqsggfaerv vmneshcykv pdfvpldvaa liqplavcwh 181 airvcefkag staliigagp iglgtilaln aagckdivvs epakvrrela ekmgarvydp 241 tahaakesid ylrsiadggd gfdytfdcsg levtlnaaiq cltfrgtavn lamwghhkiq 301 fspmditlhe rkytgsmcyt hhdfeaviea leegrididr arhmitgrvn iedgldgaim 361 klinekesti kiiltpnnhg elnreadnek keiselssrk dqerlresin eaklrht // LOCUS NP_009341 382 aa linear PLN 30-JUN-2025 DEFINITION (R,R)-butanediol dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009341 VERSION NP_009341.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178202.2 REFERENCE 1 (residues 1 to 382) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 382) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 382) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 382) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06929. On Apr 26, 2011 this sequence version replaced NP_009341.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..382 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..382 /product="(R,R)-butanediol dehydrogenase" /EC_number="1.1.1.4" /calculated_mol_wt="41451" Region 1..374 /region_name="butanediol_DH_like" /note="(2R,3R)-2,3-butanediol dehydrogenase; cd08233" /db_xref="CDD:176195" Site order(39..41,44,173,177,197..202,221..222,226,240,267..268, 270,293,295,315..317) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:176195" Site order(39,41,73,173) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176195" CDS 1..382 /gene="BDH1" /locus_tag="YAL060W" /coded_by="NM_001178202.2:1..1149" /experiment="EXISTENCE:direct assay:GO:0000721 (R,R)-butanediol dehydrogenase activity [PMID:10938079]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0006066 alcohol metabolic process [PMID:10938079]" /experiment="EXISTENCE:mutant phenotype:GO:0034079 butanediol biosynthetic process [PMID:19966022]" /note="NAD-dependent (R,R)-butanediol dehydrogenase; catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source" /db_xref="GeneID:851239" /db_xref="SGD:S000000056" ORIGIN 1 mralayfkkg dihftndipr peiqtddevi idvswcgicg sdlheyldgp ifmpkdgech 61 klsnaalpla mghemsgivs kvgpkvtkvk vgdhvvvdaa sscadlhcwp hskfynskpc 121 dacqrgsenl cthagfvglg visggfaeqv vvsqhhiipv pkeipldvaa lveplsvtwh 181 avkisgfkkg ssalvlgagp iglctilvlk gmgaskivvs eiaerriema kklgvevfnp 241 skhghksiei lrgltkshdg fdysydcsgi qvtfetslka ltfkgtatni avwgpkpvpf 301 qpmdvtlqek vmtgsigyvv edfeevvrai hngdiamedc kqlitgkqri edgwekgfqe 361 lmdhkesnvk illtpnnhge mk // LOCUS NP_009342 212 aa linear PLN 30-JUN-2025 DEFINITION Ecm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009342 VERSION NP_009342.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178201.2 REFERENCE 1 (residues 1 to 212) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 212) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 212) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 212) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06930. On Apr 26, 2011 this sequence version replaced NP_009342.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..212 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..212 /product="Ecm1p" /calculated_mol_wt="23760" Region 31..152 /region_name="Alb1" /note="pfam09135" /db_xref="CDD:430427" CDS 1..212 /gene="ECM1" /locus_tag="YAL059W" /coded_by="NM_001178201.2:1..639" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:11583615]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11583615]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:20348449]" /experiment="EXISTENCE:direct assay:GO:1990275 preribosome binding [PMID:35139378]" /experiment="EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:20348449|PMID:11583615]" /note="Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm" /db_xref="GeneID:851240" /db_xref="SGD:S000000055" ORIGIN 1 mweqrrqkvv fsltilvryr lkqsmakkis knsraarqsd alepevkdls elpraektdl 61 tnilirtaak nealleakis kkankskrgk klnkkaledk lansissmdr drlvkalnft 121 nrldgkiaks israkyiqnt rkagwdstne tikkelafln gglsvqaksa segnaekede 181 eipevfdsla edntvqktpt nrfgvlpddv ee // LOCUS NP_009343 502 aa linear PLN 30-JUN-2025 DEFINITION calnexin [Saccharomyces cerevisiae S288C]. ACCESSION NP_009343 VERSION NP_009343.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178200.1 REFERENCE 1 (residues 1 to 502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 502) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06931. Method: conceptual translation. FEATURES Location/Qualifiers source 1..502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..502 /product="calnexin" /calculated_mol_wt="56837" Region 33..413 /region_name="Calreticulin" /note="Calreticulin family; pfam00262" /db_xref="CDD:459737" CDS 1..502 /gene="CNE1" /locus_tag="YAL058W" /gene_synonym="FUN48" /coded_by="NM_001178200.1:1..1509" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:7814381]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16002399]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15173200]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:7814381]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:15173200]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:16002399]" /note="Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast" /db_xref="GeneID:851241" /db_xref="SGD:S000000054" ORIGIN 1 mkfsaylwwl flnlalvkgt sllsnvtlae dsfwehfqay tntkhlnqew itseavnneg 61 skiygaqwrl sqgrlqgsaw dkgiavrtgn aaamighlle tpinvsetdt lvvqyeikld 121 nsltcggafi klmsgfmnve alkhyapdte gvelvfgpdy capeingvqf ainkvdkith 181 esklrylqem plskltdtsq shlytliide saqsfqilid gktvmvrehi edkkkvnfep 241 pitpplmipd vsvakphdwd driripdpea vklsdrderd plmiphpdgt eppewnssip 301 eyildpnaqk pswwkelehg ewippmiknp lctaergcgq qipglinnak ykgpgelnei 361 inpnymgewh ppeienplyy eeqhplrien visgvilefw sgspnmlisn iyvgknvtea 421 qiignktwlm rdrafrgsdg pterkfmnsr lgnlqttfhn erespnpfdr iidrileqpl 481 kfvltaavvl lttsvlccvv ft // LOCUS NP_009345 880 aa linear PLN 30-JUN-2025 DEFINITION Gpb2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009345 VERSION NP_009345.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178199.2 REFERENCE 1 (residues 1 to 880) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 880) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 880) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 880) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06932. On Apr 26, 2011 this sequence version replaced NP_009345.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..880 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..880 /product="Gpb2p" /calculated_mol_wt="98525" CDS 1..880 /gene="GPB2" /locus_tag="YAL056W" /gene_synonym="KRH1" /coded_by="NM_001178199.2:1..2643" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16030250]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]" /experiment="EXISTENCE:genetic interaction:GO:0004862 cAMP-dependent protein kinase inhibitor activity [PMID:16924114|PMID:16278446]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:12150916]" /experiment="EXISTENCE:genetic interaction:GO:0010255 glucose mediated signaling pathway [PMID:12150916]" /experiment="EXISTENCE:genetic interaction:GO:0046580 negative regulation of Ras protein signal transduction [PMID:16793550]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0010255 glucose mediated signaling pathway [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:12586695]" /experiment="EXISTENCE:physical interaction:GO:0032794 GTPase activating protein binding [PMID:16793550]" /note="Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication" /db_xref="GeneID:851243" /db_xref="SGD:S000000052" ORIGIN 1 meissspwnd ggyspyernr vavspfssal egeerietsr slgdhcfepl pyvtnylsif 61 alfgkeifgd kgnvssrney llkkyyslkk pfvlrhngha lknpdmplqr ndilqtnfmv 121 dkflnrtvrs vnfnnfkiis dmqsksgrgt ksgtnqnqsa daiqniclps ipsalpyfqy 181 yrklltvntk ewdilklhsl wvpklrkdfk dfslygdkns lkpidshyde dntmkknlff 241 erspsrqtld gkgcaskgyd issgnmiips lfsedklpal tyhcsvelng niyifgglmp 301 cysyeedapm lndffvdgik nlpppllpqv innpsmvnnp hlyvasipsc rfskpkmggy 361 ipppllcvqg skltdrhiff yggfeirtet rgdengkyhl kkrlyvnntg yildimsfkf 421 tkidiivqps kynayptmss rfghlqisid npnrrasvhs ssmneihkmg sasmkqgssi 481 tsgrlekaav lsslphntvh tviifggyrq tgddryeamn dlwkieipvi rrgkkgyckf 541 setanaillt psekdksdwp eerafsafsv hgtslmdrss ldmrllnnlk nhfvlkpsyi 601 sqdrvvspkp vfpmmvhgth qdlfnsgsaa qespkagasa ssasaasfdp dmddnlenyi 661 vnpgrksssi pmtaigrqrl ilsqekpvgk tvvlhggsng lnvlddmwlm dlecetwtpi 721 etfakadsse dgdekldsvn vglvghrmes igricvcigg mvqedvdqfy senddepprk 781 rkvdtlplgg nflntidlst qcweehkitl skkeddedrq dsenedtnsn ivvgvggtsl 841 qcdksiilig glisrrsnvk eiylhgtitk sifpsvnpsa // LOCUS NP_009346 180 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein transferase activating protein PEX22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009346 VERSION NP_009346.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178198.1 REFERENCE 1 (residues 1 to 180) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 180) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 180) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 180) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06933. Method: conceptual translation. FEATURES Location/Qualifiers source 1..180 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..180 /product="ubiquitin-protein transferase activating protein PEX22" /calculated_mol_wt="19746" Region 51..167 /region_name="Peroxin-22" /note="Peroxisomal biogenesis protein family; pfam12827" /db_xref="CDD:403894" CDS 1..180 /gene="PEX22" /locus_tag="YAL055W" /gene_synonym="YAF5" /coded_by="NM_001178198.1:1..543" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0031398 positive regulation of protein ubiquitination [PMID:25162638]" /experiment="EXISTENCE:direct assay:GO:0097027 ubiquitin-protein transferase activator activity [PMID:22085930]" /experiment="EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:25162638]" /experiment="EXISTENCE:mutant phenotype:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:17452527]" /note="Putative peroxisomal membrane protein; required for import of peroxisomal proteins; functionally complements a Pichia pastoris pex22 mutation" /db_xref="GeneID:851244" /db_xref="SGD:S000000051" ORIGIN 1 mpppsrsrin ktrtlgivgt aiavlvtsyy iyqkvtsake dngarppegd svkenkkark 61 skciimsksi qglpikweey aadevvllvp tshtdgsmkq aigdafrktk nehkiiycds 121 mdglwscvrr lgkfqcilns rdftssggsd aavvpedigr fvkfvvdsdv edvlidtlcn // LOCUS NP_009347 713 aa linear PLN 30-JUN-2025 DEFINITION acetate--CoA ligase 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009347 VERSION NP_009347.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178197.1 REFERENCE 1 (residues 1 to 713) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 713) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 713) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 713) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06934. Method: conceptual translation. FEATURES Location/Qualifiers source 1..713 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..713 /product="acetate--CoA ligase 1" /EC_number="6.2.1.1" /calculated_mol_wt="79010" Region 74..700 /region_name="ACS" /note="Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); cd05966" /db_xref="CDD:341270" Site order(220..222,248,251,253,361,366..367,389..391,415..416, 419,442..445,467..472,559,571,574,582..585,650,655..656) /site_type="active" /db_xref="CDD:341270" Site order(220..222,248,251,253,361,367,389..391,415..416,419, 582..584,650,655) /site_type="other" /note="CoA binding site [chemical binding]" /db_xref="CDD:341270" Site order(317,320..325,327..328) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341270" Site order(366..367,442..445,467..472,559,571,574,585) /site_type="other" /note="AMP binding site [chemical binding]" /db_xref="CDD:341270" Site order(366..367,442..443,470) /site_type="other" /note="acetate binding site [chemical binding]" /db_xref="CDD:341270" CDS 1..713 /gene="ACS1" /locus_tag="YAL054C" /gene_synonym="FUN44" /coded_by="NM_001178197.1:1..2142" /experiment="EXISTENCE:direct assay:GO:0003987 acetate-CoA ligase activity [PMID:8910545]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9711835]" /experiment="EXISTENCE:direct assay:GO:0006085 acetyl-CoA biosynthetic process [PMID:8910545]" /experiment="EXISTENCE:direct assay:GO:0016880 acid-ammonia (or amide) ligase activity [PMID:18305111]" /experiment="EXISTENCE:mutant phenotype:GO:0019654 acetate fermentation [PMID:1363452]" /note="Acetyl-coA synthetase isoform; along with Acs2p, acetyl-CoA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions; metabolites mediate the formation of filament assemblies in meiotic cells, storing Acs1p in an inactive state and promoting efficient return to growth after starvation" /db_xref="GeneID:851245" /db_xref="SGD:S000000050" ORIGIN 1 mspsavqssk leeqsseidk lkakmsqsaa taqqkkehey ehltsvkivp qrpisdrlqp 61 aiathysphl dglqdyqrlh kesiedpakf fgskatqfln wskpfdkvfi pdpktgrpsf 121 qnnawflngq lnacyncvdr halktpnkka iifegdepgq gysitykell eevcqvaqvl 181 tysmgvrkgd tvavympmvp eaiitllais rigaihsvvf agfssnslrd rindgdskvv 241 ittdesnrgg kvietkrivd dalretpgvr hvlvyrktnn psvafhaprd ldwatekkky 301 ktyypctpvd sedplfllyt sgstgapkgv qhstagyllg alltmrytfd thqedvffta 361 gdigwitght yvvygpllyg catlvfegtp aypnysrywd iidehkvtqf yvaptalrll 421 kragdsyien hslkslrclg svgepiaaev wewysekigk neipivdtyw qtesgshlvt 481 plaggvtpmk pgsasfpffg idavvldpnt geelntshae gvlavkaawp sfartiwknh 541 dryldtylnp ypgyyftgdg aakdkdgyiw ilgrvddvvn vsghrlstae ieaaiiedpi 601 vaecavvgfn ddltgqavaa fvvlknkssw statddelqd ikkhlvftvr kdigpfaapk 661 liilvddlpk trsgkimrri lrkilagesd qlgdvstlsn pgivrhlids vkl // LOCUS NP_009348 783 aa linear PLN 30-JUN-2025 DEFINITION flavin adenine dinucleotide transporter FLC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009348 VERSION NP_009348.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178196.2 REFERENCE 1 (residues 1 to 783) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 783) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 783) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 783) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 783) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 783) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06935. On Apr 26, 2011 this sequence version replaced NP_009348.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..783 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..783 /product="flavin adenine dinucleotide transporter FLC2" /calculated_mol_wt="87338" Region 38..177 /region_name="TRP_N" /note="ML-like domain; pfam14558" /db_xref="CDD:434037" Region 182..628 /region_name="TRP" /note="Transient receptor potential (TRP) ion channel; pfam06011" /db_xref="CDD:428720" CDS 1..783 /gene="FLC2" /locus_tag="YAL053W" /coded_by="NM_001178196.2:1..2352" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16717099]" /experiment="EXISTENCE:genetic interaction:GO:0030148 sphingolipid biosynthetic process [PMID:27462707]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0015230 FAD transmembrane transporter activity [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0015883 FAD transport [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0055074 calcium ion homeostasis [PMID:25573187]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0071476 cellular hypotonic response [PMID:25573187]" /note="Putative calcium channel involved in calcium release under hypotonic stress; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; targeted to vacuole via AP-3 pathway; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication" /db_xref="GeneID:851246" /db_xref="SGD:S000000049" ORIGIN 1 miflntfarc lltcfvlcsg tarssdtndt tpasakhlqt tslltcmdns qltasffdvk 61 fypdnntvif didatttlng nvtvkaellt yglkvldktf dlcslgqvsl cplsagridv 121 mstqviessi tkqfpgiayt ipdldaqvrv vayaqndtef etplacvqai lsngktvqtk 181 yaawpiaais gvgvltsgfv svigysataa hiasnsislf iyfqnlaita mmgvsrvppi 241 aaawtqnfqw smgiintnfm qkifdwyvqa tngvsnvvva nkdvlsisvq kraismasss 301 dynfdtildd snlyttsekd psnysakilv lrgiervayl anielsnffl tgivfflffl 361 fvvvvsliff kallevltra rilketsnff qyrknwgsii kgtlfrlsii afpqvsllai 421 weftqvnspa ivvdavvill iitgllvygt irvfikgres lrlyknpayl lysdtyflnk 481 fgflyvqfka dkfwwllpll syaflrslfv avlqnqgkaq amiifviela yfvclcwirp 541 yldkrtnvfn iaihlvnlin affflffsnl fkqpavvssv mavilfvlna vfalflllft 601 ivtctlallh rnpdvryqpm kddrvsfipk iqndfdgknk ndselfelrk avmdtnenee 661 ekmfrddtfg knlnantnta rlfddetsss sfkqnsspfd asevteqpvq ptsavmgtgg 721 sflspqyqra ssasrtnlap nntstsslmk pesslylgns nksyshfnnn gsnenarnnn 781 pyl // LOCUS NP_009349 1047 aa linear PLN 30-JUN-2025 DEFINITION oleate-activated transcription factor OAF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009349 VERSION NP_009349.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178195.2 REFERENCE 1 (residues 1 to 1047) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1047) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1047) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1047) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1047) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1047) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06936. On Apr 26, 2011 this sequence version replaced NP_009349.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1047 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1047 /product="oleate-activated transcription factor OAF1" /calculated_mol_wt="118761" Site order(61,65,70..73,75,78,88) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Region 64..100 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(66,69,76,83,86,93) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 338..784 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..1047 /gene="OAF1" /locus_tag="YAL051W" /gene_synonym="YAF1" /coded_by="NM_001178195.2:1..3144" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9288897]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10428786]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0089716 Pip2-Oaf1 complex [PMID:9288897]" /experiment="EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9288897]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8972187|PMID:10428786]" /experiment="EXISTENCE:mutant phenotype:GO:0032000 positive regulation of fatty acid beta-oxidation [PMID:8972187]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8972187]" /experiment="EXISTENCE:mutant phenotype:GO:0071400 cellular response to oleic acid [PMID:8972187]" /experiment="EXISTENCE:physical interaction:GO:0089716 Pip2-Oaf1 complex [PMID:8972187]" /note="Oleate-activated transcription factor; subunit of a heterodimeric complex with Pip2p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; regulates chromatin silencing at telomeres; involved in diauxic shift; OAF1 has a paralog, PIP2, that arose from the whole genome duplication" /db_xref="GeneID:851247" /db_xref="SGD:S000000048" ORIGIN 1 mvenstqkap hagnddnsst kpyseafflg fnnptpglea ehsstspape nsethnrkrn 61 rilfvcqacr ksktkcdrek pecgrcvkhg lkcvydvskq papripskda iisrlekdmf 121 ywkdkamkll terevnesgk rsaspintnn asgdspdtkk qhkmepiyeq sgngdinngt 181 rndieinlyr shptmimskv mkrevkplse nyiiiqdcfl kilvtsvfld tskntmipal 241 tananitraq psvannllkl kemlirqcqt edeknrvnef tdrilqntns nrnlkigmll 301 smlynsvgyq yledhcpqgg eysdllrnli neceailpsy eiieryknhf yeyvypslpf 361 ieleifeesl sqtifpdpnn pskvqirmgs thlrakvenl slllvilkls ymsirfldhs 421 tadssfylsk eiidkypipn dfillsqrcl asenwcacan eniiscllyi wsffafspee 481 gdfflehptd visslimmls tsiglhrdps dfpqlispst sdkrtlnhrr ilwlsivtvc 541 sfeaslkgrh svspislmal flnikdpdsl tvymnrvrgd lsdinnhkll rihkftfkra 601 qlalllsdld nltmtyygsf hlhsiefire kieifveenf pivplksvaq dksdlddmnv 661 isemnilsse nsssfhnrim nkllmlrtsm avflhfetli tkdksifpfy kkyfmvscmd 721 alslinyfnk ffngeyrhai ssltsfnvtk fiqlalssti fsllgiilri glaihmlsse 781 vqklsgttdp rikelntkve kfstlqrdle salegiycsa sehlrftyfp vfkmlalfdv 841 ivqrmrkgel whgiftmiqm eqmhsriikt lsitlgvkld kkdrlleelm acnhvanfsv 901 edidelnrni kkeiqissgl kppvntidlt ngepfgnavp tftktwsssl dnleklssaa 961 avgqsldyns glrqgplagg gskeqtpiag mnnlnnsina tpivdnssgs qlpngfdrgq 1021 anntpfpgyf ggldlfdydf lfgndfa // LOCUS NP_009350 246 aa linear PLN 30-JUN-2025 DEFINITION protein AIM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009350 VERSION NP_009350.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178194.1 REFERENCE 1 (residues 1 to 246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 246) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06937. Method: conceptual translation. FEATURES Location/Qualifiers source 1..246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..246 /product="protein AIM2" /calculated_mol_wt="26958" Region 31..242 /region_name="DLH" /note="Dienelactone hydrolase family; pfam01738" /db_xref="CDD:396343" CDS 1..246 /gene="AIM2" /locus_tag="YAL049C" /coded_by="NM_001178194.1:1..741" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor" /db_xref="GeneID:851248" /db_xref="SGD:S000000047" ORIGIN 1 masnqpgkcc fegvchdgtp kgrreeifgl dtyaagstsp kekviviltd vygnkfnnvl 61 ltadkfasag ymvfvpdilf gdaissdkpi drdawfqrhs pevtkkivdg fmkllkleyd 121 pkfigvvgyc fgakfavqhi sgdgglanaa aiahpsfvsi eeieaidskk pilisaaeed 181 hifpanlrhl teeklkdnha tyqldlfsgv ahgfaargdi sipavkyake kvlldqiywf 241 nhfsnv // LOCUS NP_009351 662 aa linear PLN 30-JUN-2025 DEFINITION ERMES complex Ca(2+)-binding regulatory GTPase GEM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009351 VERSION NP_009351.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178193.1 REFERENCE 1 (residues 1 to 662) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 662) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 662) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 662) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06938. Method: conceptual translation. FEATURES Location/Qualifiers source 1..662 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..662 /product="ERMES complex Ca(2+)-binding regulatory GTPase GEM1" /calculated_mol_wt="75020" Region 6..186 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site 12..19 /site_type="other" /note="G1 box" /db_xref="CDD:206648" Site order(14..20,65,116..117,119,165..167) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206648" Site 42 /site_type="other" /note="G2 box" /db_xref="CDD:206648" Site order(46..47,50) /site_type="other" /note="Switch I region" /db_xref="CDD:206648" Site 62..65 /site_type="other" /note="G3 box" /db_xref="CDD:206648" Site order(64..65,79..80) /site_type="other" /note="Switch II region" /db_xref="CDD:206648" Site 116..119 /site_type="other" /note="G4 box" /db_xref="CDD:206648" Site 165..167 /site_type="other" /note="G5 box" /db_xref="CDD:206648" Region 236..329 /region_name="EF_assoc_2" /note="EF hand associated; pfam08356" /db_xref="CDD:462444" Region 369..434 /region_name="EF_assoc_1" /note="EF hand associated; pfam08355" /db_xref="CDD:462443" Region 445..624 /region_name="Miro2" /note="Mitochondrial Rho family 2 (Miro2), C-terminal; cd01892" /db_xref="CDD:206679" Site 455..462 /site_type="other" /note="G1 box" /db_xref="CDD:206679" Site order(458..463,503..504,506,561,563,592..593) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206679" Site 477..485 /site_type="other" /note="Switch I region" /db_xref="CDD:206679" Site 478 /site_type="other" /note="G2 box" /db_xref="CDD:206679" Site 503..506 /site_type="other" /note="G3 box" /db_xref="CDD:206679" Site order(505..516,522..524) /site_type="other" /note="Switch II region" /db_xref="CDD:206679" Site 560..563 /site_type="other" /note="G4 box" /db_xref="CDD:206679" Site 591..593 /site_type="other" /note="G5 box" /db_xref="CDD:206679" CDS 1..662 /gene="GEM1" /locus_tag="YAL048C" /gene_synonym="GON1" /coded_by="NM_001178193.1:1..1989" /experiment="EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:21036903]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:15479738]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:37366411]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:18245340]" /experiment="EXISTENCE:genetic interaction:GO:0055091 phospholipid homeostasis [PMID:21825164]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:18245340]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:15479738]" /experiment="EXISTENCE:mutant phenotype:GO:0010821 regulation of mitochondrion organization [PMID:21825164]" /experiment="EXISTENCE:mutant phenotype:GO:0015886 heme transport [PMID:32265272]" /experiment="EXISTENCE:mutant phenotype:GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering [PMID:23682313|PMID:21825164]" /experiment="EXISTENCE:physical interaction:GO:0032865 ERMES complex [PMID:21825164|PMID:21945531]" /note="Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases" /db_xref="GeneID:851249" /db_xref="SGD:S000000046" ORIGIN 1 mtketirvvi cgdegvgkss livsltkaef iptiqdvlpp isiprdfsss ptyspkntvl 61 idtsdsdlia ldhelksadv iwlvycdhes ydhvslfwlp hfrslglnip vilcknkcds 121 isnvnanamv vsensdddid tkvedeefip ilmefkeidt ciktsaktqf dlnqafylcq 181 raithpispl fdamvgelkp lavmalkrif llsdlnqdsy lddneilglq kkcfnksidv 241 nelnfikdll ldiskhdqey inrklyvpgk gitkdgflvl nkiyaergrh ettwailrtf 301 hytdslcind kilhprlvvp dtssvelspk gyrflvdifl kfdidndggl nnqelhrlfk 361 ctpglpklwt stnfpfstvv nnkgcitlqg wlaqwsmttf lnystttayl vyfgfqedar 421 lalqvtkprk mrrrsgklyr snindrkvfn cfvigkpccg ksslleaflg rsfseeyspt 481 ikpriavnsl elkggkqyyl ilqelgeqey ailenkdklk ecdvicltyd ssdpesfsyl 541 vslldkfthl qdlplvfvas kadldkqqqr cqiqpdelad elfvnhplhi ssrwlsslne 601 lfikiteaal dpgkntpglp eetaakdvdy rqtalifgst vgfvalcsft lmklfksskf 661 sk // LOCUS NP_009352 622 aa linear PLN 30-JUN-2025 DEFINITION gamma-tubulin complex subunit SPC72 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009352 VERSION NP_009352.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178192.2 REFERENCE 1 (residues 1 to 622) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 622) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 622) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 622) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06939. On Apr 26, 2011 this sequence version replaced NP_009352.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..622 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..622 /product="gamma-tubulin complex subunit SPC72" /calculated_mol_wt="71975" Region <295..578 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 573..614 /region_name="Mto2_bdg" /note="Micro-tubular organizer Mto1 C-term Mto2-binding region; pfam12808" /db_xref="CDD:315477" CDS 1..622 /gene="SPC72" /locus_tag="YAL047C" /gene_synonym="LDB4" /coded_by="NM_001178192.2:1..1869" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:9382872]" /experiment="EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:9670012]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:9382872]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:9670012|PMID:12970190]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:12970190]" /experiment="EXISTENCE:direct assay:GO:0061499 outer plaque of mitotic spindle pole body [PMID:9585415]" /experiment="EXISTENCE:direct assay:GO:0099609 microtubule lateral binding [PMID:9382872]" /experiment="EXISTENCE:direct assay:GO:1905721 mitotic spindle astral microtubule end [PMID:12970190]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:17967947]" /experiment="EXISTENCE:mutant phenotype:GO:0007020 microtubule nucleation [PMID:18573877]" /experiment="EXISTENCE:mutant phenotype:GO:0030953 astral microtubule organization [PMID:12970190]" /experiment="EXISTENCE:mutant phenotype:GO:0031122 cytoplasmic microtubule organization [PMID:9606209]" /experiment="EXISTENCE:mutant phenotype:GO:1990734 astral microtubule anchoring at mitotic spindle pole body [PMID:12970190]" /experiment="EXISTENCE:physical interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:17967947]" /experiment="EXISTENCE:physical interaction:GO:0110121 gamma-tubulin complex localization to cytoplasmic side of mitotic spindle pole body [PMID:9670012]" /note="Gamma-tubulin small complex (gamma-TuSC) receptor; recruits the gamma-TuSC complex to the cytoplasmic side of the SPB, connecting nuclear microtubules to the SPB; involved in astral microtubule formation, stabilization, and with Stu2p, anchoring astral MTs at the cytoplasmic face of the SPB, and regulating plus-end MT dynamics; regulated by Cdc5 kinase" /db_xref="GeneID:851250" /db_xref="SGD:S000000045" ORIGIN 1 mvrrwipsgr hlrnndntgd dddseftnsm dsgmsipslr dsmttrsshn dpikpalmnd 61 snkvknleke ltnakikiqv lyeyirripn kdgnapslgn dtdfrnsiie glnleinklk 121 qdlkakevey qdtlqfvqen lensesivnt inhllsfilt hfneqdenah lldkeeretl 181 eetlelssdy vlekmdtlsk fiiqflqdfl hsksraeskq dkeeflslaq sspagsqles 241 rdspsskeen tdggyqndei hdsnnhidte nvmanstslp isavesrfek tldtqleivi 301 enlhkeydqf insirlkfek sqklekiias klneqshlld sleleensss viekqdhlis 361 qlkekiesqs vlinnleklk ediikmkqne kvltkeletq tkinklkenn wdsyindlek 421 qindlqidks eefhviqnql dkldlenyql knqlntldnq klilsqyesn fikfnqnlll 481 hldsifnilq kilqessiaq fdrkmksiks vpnalknlnl iqpkleslyt fietalesii 541 nsyisslism etpeqphqqg neltatpnke ltlrieelqr rwisererrk ldanaseari 601 kaleqenesl rsklfnlsin np // LOCUS NP_009353 118 aa linear PLN 30-JUN-2025 DEFINITION Bol3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009353 VERSION NP_009353.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178191.1 REFERENCE 1 (residues 1 to 118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 118) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06940. Method: conceptual translation. FEATURES Location/Qualifiers source 1..118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..118 /product="Bol3p" /calculated_mol_wt="13225" Region 46..108 /region_name="BolA" /note="BolA-like protein; pfam01722" /db_xref="CDD:460305" CDS 1..118 /gene="BOL3" /locus_tag="YAL046C" /gene_synonym="AIM1" /coded_by="NM_001178191.1:1..357" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:27532772]" /experiment="EXISTENCE:genetic interaction:GO:0051604 protein maturation [PMID:27532773|PMID:27532772]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:27532772]" /experiment="EXISTENCE:physical interaction:GO:0051604 protein maturation [PMID:27532773]" /note="Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress by acting along with Nfu1p at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to mitochondrial client proteins like lipoate synthase and succinate dehydrogenase; sequence similarity to human BOLA family member, BOLA3, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS2)" /db_xref="GeneID:851251" /db_xref="SGD:S000000044" ORIGIN 1 mklpqtmlrs isvkhvrwpr iltgsklwys tqmamtpeek mitdklqqel epevckvqdv 61 sggcgsmfai nitskkfngl slikqhqlvn rilrddisrw hglqlttkks tgkgpass // LOCUS NP_075206 110 aa linear PLN 30-JUN-2025 DEFINITION Bol1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_075206 VERSION NP_075206.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184453.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 110) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06941. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..110 /product="Bol1p" /calculated_mol_wt="12406" Region 35..104 /region_name="BolA" /note="BolA-like protein; pfam01722" /db_xref="CDD:460305" CDS 1..110 /gene="BOL1" /locus_tag="YAL044W-A" /coded_by="NM_001184453.1:1..333" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:27532772]" /experiment="EXISTENCE:genetic interaction:GO:0044572 [4Fe-4S] cluster assembly [PMID:27532773]" /experiment="EXISTENCE:genetic interaction:GO:0051604 protein maturation [PMID:27532772]" /experiment="EXISTENCE:mutant phenotype:GO:0044572 [4Fe-4S] cluster assembly [PMID:27532773]" /experiment="EXISTENCE:physical interaction:GO:0044572 [4Fe-4S] cluster assembly [PMID:27532773]" /note="Mitochondrial matrix protein involved in Fe-S cluster biogenesis; facilitates [4Fe-2S] cluster inception into mitochondrial proteins such as lipoate synthase and succinate dehydrogenase; interacts and may function with Grx5p at an early step in Fe-S cluster biosynthesis; forms dimeric complexes with Grx5p and Nfu1p that alter the stability of shared Fe/S clusters; sequence similarity to human BOLA family member, BOLA1 and S. pombe uvi31, a putative DNA repair protein" /db_xref="GeneID:851252" /db_xref="SGD:S000007586" ORIGIN 1 mfkramstdg pvartilkrl ecgfpdyknf afglyndshk hkghagvqgn vsaethfrie 61 mvskkfeglk lpqrhrmvys llqdemaqan gihalqlslk tpqeyeskak // LOCUS NP_009355 170 aa linear PLN 30-JUN-2025 DEFINITION glycine decarboxylase subunit H [Saccharomyces cerevisiae S288C]. ACCESSION NP_009355 VERSION NP_009355.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178189.1 REFERENCE 1 (residues 1 to 170) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 170) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 170) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 170) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06942. On Nov 27, 2009 this sequence version replaced NP_009355.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..170 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..170 /product="glycine decarboxylase subunit H" /calculated_mol_wt="18662" Region 40..169 /region_name="gcvH" /note="glycine cleavage system H protein; TIGR00527" /db_xref="CDD:200024" Site 102 /site_type="other" /note="lipoyl attachment site [posttranslational modification]" /db_xref="CDD:133457" CDS 1..170 /gene="GCV3" /locus_tag="YAL044C" /coded_by="NM_001178189.1:1..513" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19570983|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0031405 lipoic acid binding [PMID:32974306]" /experiment="EXISTENCE:genetic interaction:GO:0006730 one-carbon metabolic process [PMID:10871621]" /experiment="EXISTENCE:mutant phenotype:GO:0005960 glycine cleavage complex [PMID:9020168]" /experiment="EXISTENCE:mutant phenotype:GO:0006546 glycine catabolic process [PMID:9020168]" /experiment="EXISTENCE:mutant phenotype:GO:0009249 protein lipoylation [PMID:19570983]" /note="H subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF" /db_xref="GeneID:851254" /db_xref="SGD:S000000042" ORIGIN 1 mlrttrlwtt rmptvsklfl rnssgnalnk nklpflyssq gpqavrytsq hewiavhqdk 61 tafvgitkya tdalgdatyv elpevgteia qgeslgsies vksaseiyqp adgtveeint 121 nleenpgvvn edpmgdgwlv kmklgegvnv eqveglmsle qyektlvhdd // LOCUS NP_009356 785 aa linear PLN 30-JUN-2025 DEFINITION RNA-processing protein PTA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009356 VERSION NP_009356.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178188.1 REFERENCE 1 (residues 1 to 785) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 785) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 785) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 785) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06943. Method: conceptual translation. FEATURES Location/Qualifiers source 1..785 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..785 /product="RNA-processing protein PTA1" /calculated_mol_wt="88342" Region 91..327 /region_name="SYMPK_PTA1_N" /note="Symplekin/PTA1 N-terminal; pfam11935" /db_xref="CDD:463403" CDS 1..785 /gene="PTA1" /locus_tag="YAL043C" /gene_synonym="FUN39" /coded_by="NM_001178188.1:1..2358" /experiment="EXISTENCE:curator inference:GO:0003723 RNA binding [PMID:10523662]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204|PMID:10523662|PMID:9099738]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:1508188]" /experiment="EXISTENCE:physical interaction:GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled [PMID:12819204]" /note="Subunit of holo-CPF; holo-CPF is a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII" /db_xref="GeneID:851255" /db_xref="SGD:S000000041" ORIGIN 1 mssaemeqll qaktlamhnn ptemlpkvle ttasmyhngn lsklklplak fftqlvldvv 61 smdspiante rpfiaaqylp lllamaqsta dvlvyknivl imcasyplvl dlvaktsnqe 121 mfdqlcmlkk fvlshwrtay plratvddet dveqwlaqid qnigvklati kfisevvlsq 181 tkspsgnein sstipdnhpv lnkpalesea krlldmllny lieeqymvss vfigiinsls 241 fvikrrpqtt irilsgllrf nvdakfpleg ksdlnyklsk rfverayknf vqfglknqii 301 tkslssgsgs siyskltkis qtlhvigeet kskgilnfdp skgnskktls rqdklkyisl 361 wkrqlsalls tlgvstktpt pvsapatgss tenmldqlki lqkytlnkas hqgntffnns 421 pkpisntyss vyslmnssns nqdvtqlpnd iliklsteai lqmdstklit glsivasryt 481 dlmntyinsv pssssskrks dddddgndne evgndgptan skkikmetep laeepeeped 541 ddrmqkmlqe eesaqeisgd ankstsaike iappfepdsl tqdeklkyls kltkklfels 601 grqdttraks sssssilldd ddssswlhvl irlvtrgiea qeasdliree llgffiqdfe 661 qrvsliiewl neewffqtsl hqdpsnykkw slrvleslgp flenkhrrff irlmselpsl 721 qsdhlealkp icldparssl gfqtlkflim frppvqdtvr dllhqlkqed eglhkqcdsl 781 ldrlk // LOCUS NP_009358 415 aa linear PLN 30-JUN-2025 DEFINITION retrograde cargo receptor ERV46 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009358 VERSION NP_009358.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178187.1 REFERENCE 1 (residues 1 to 415) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 415) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 415) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 415) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06944. Method: conceptual translation. FEATURES Location/Qualifiers source 1..415 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..415 /product="retrograde cargo receptor ERV46" /calculated_mol_wt="46104" Region 6..96 /region_name="ERGIC_N" /note="Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC); pfam13850" /db_xref="CDD:464000" Region 143..399 /region_name="COPIIcoated_ERV" /note="Endoplasmic reticulum vesicle transporter; pfam07970" /db_xref="CDD:462327" CDS 1..415 /gene="ERV46" /locus_tag="YAL042W" /gene_synonym="FUN9" /coded_by="NM_001178187.1:1..1248" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:11157978]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11157978]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11157978]" /note="Protein localized to COPII-coated vesicles; forms a complex with Erv41p; involved in the membrane fusion stage of transport" /db_xref="GeneID:851256" /db_xref="SGD:S000000040" ORIGIN 1 mkrstllsld afakteedvr vrtragglit lscilttlfl lvnewgqfns vvtrpqlvvd 61 rdrhakleln mdvtfpsmpc dlvnldimdd sgemqldild agftmsrlns egrpvgdate 121 lhvggngdgt apvnndpnyc gpcygakdqs qnenlaqeek vccqdcdavr sayleagwaf 181 fdgknieqce regyvskine hlnegcrikg saqinriqgn lhfapgkpyq nayghfhdts 241 lydktsnlnf nhiinhlsfg kpiqshskll gndkrhggav vatspldgrq vfpdrnthfh 301 qfsyfakivp tryeyldnvv ietaqfsatf hsrplaggrd kdhpntlhvr ggipgmfvff 361 emsplkvink eqhgqtwsgf ilncitsigg vlavgtvmdk lfykaqrsiw gkksq // LOCUS NP_009359 854 aa linear PLN 30-JUN-2025 DEFINITION Rho family guanine nucleotide exchange factor CDC24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009359 VERSION NP_009359.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178186.1 REFERENCE 1 (residues 1 to 854) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 854) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 854) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 854) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06945. Method: conceptual translation. FEATURES Location/Qualifiers source 1..854 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..854 /product="Rho family guanine nucleotide exchange factor CDC24" /calculated_mol_wt="96809" Region 156..242 /region_name="CDC24" /note="CDC24 Calponin; pfam06395" /db_xref="CDD:399412" Region 282..453 /region_name="RhoGEF" /note="Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; smart00325" /db_xref="CDD:214619" Site order(285,289,381,404..405,408..409,411..412,415..416, 419..420,423,448,452) /site_type="other" /note="GTPase interaction site [polypeptide binding]" /db_xref="CDD:238091" Region 455..667 /region_name="PH_Scd1" /note="Shape and Conjugation Deficiency 1 Pleckstrin homology (PH) domain; cd13246" /db_xref="CDD:270066" Region 779..853 /region_name="PB1" /note="PB1 domain; smart00666" /db_xref="CDD:214770" Site order(820,833) /site_type="other" /note="PB1 interaction site [polypeptide binding]" /db_xref="CDD:99716" Site order(820,833) /site_type="other" /note="PB1 interaction site [polypeptide binding]" /db_xref="CDD:99716" Site order(820,833) /site_type="other" /note="PB1 interaction surface [polypeptide binding]" /db_xref="CDD:99716" Site order(820,833) /site_type="other" /note="PB1 interaction surface [polypeptide binding]" /db_xref="CDD:99716" CDS 1..854 /gene="CDC24" /locus_tag="YAL041W" /gene_synonym="CLS4" /coded_by="NM_001178186.1:1..2565" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10655592]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8300560]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:10655592]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10655592|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10655592]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10087263]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:10087263]" /experiment="EXISTENCE:direct assay:GO:0120171 Cdc24p-Far1p-Gbetagamma complex [PMID:10087263]" /experiment="EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:7565673]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:7019215]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:9428768]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:7565673]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:12234925]" /experiment="EXISTENCE:mutant phenotype:GO:0031106 septin ring organization [PMID:16371506]" /experiment="EXISTENCE:mutant phenotype:GO:0043577 chemotropism [PMID:9428768]" /experiment="EXISTENCE:mutant phenotype:GO:0072697 protein localization to cell cortex [PMID:16325503]" /experiment="EXISTENCE:physical interaction:GO:0120171 Cdc24p-Far1p-Gbetagamma complex [PMID:10087263]" /note="Guanine nucleotide exchange factor (GEF) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress; thermosensitivity of the cdc24-4 mutant in the presence of sorbitol is functionally complemented by human CDC42" /db_xref="GeneID:851190" /db_xref="SGD:S000000039" ORIGIN 1 maiqtrfasg tslsdlkpkp satsisipmq nvmnkpvteq dslfhicani rkrlevlpql 61 kpflqlayqs sevlserqsl llsqkqhqel lksnganrds sdlaptlrss sistatslms 121 megisytnsn psatpnmedt lltfsmgilp itmdcdpvtq lsqlfqqgap lcilfnsvkp 181 qfklpviasd dlkvckksiy dfilgckkhf afndeelfti sdvfanstsq lvkvlevvet 241 lmnssptifp sksktqqimn aenqhrhqpq qsskkhneyv kiikefvate rkyvhdleil 301 dkyrqqllds nlitseelym lfpnlgdaid fqrrflisle inalvepskq rigalfmhsk 361 hffklyepws igqnaaiefl sstlhkmrvd esqrfiinnk lelqsflykp vqrlcrypll 421 vkellaessd dnntkeleaa ldiskniars inenqrrten hqvvkklygr vvnwkgyris 481 kfgellyfdk vfisttnsss eperefevyl fekiiilfse vvtkksassl ilkkksstsa 541 sisasnitdn ngsphhsyhk rhsnssssnn ihlssssaaa iihsstnssd nnsnnsssss 601 lfklsanepk ldlrgrimim nlnqiipqnn rslnitwesi keqgnfllkf kneetrdnws 661 sclqqlihdl kneqfkarhh sststtssta ksssmmsptt tmntpnhhns rqthdsmasf 721 ssshmkrvsd vlpkrrttss sfeseiksis enfknsipes silfrisynn nsnntsssei 781 ftllvekvwn fddlimains kisnthnnni spitkikyqd edgdfvvlgs dedwnvakem 841 laennekfln irly // LOCUS NP_009360 580 aa linear PLN 30-JUN-2025 DEFINITION cyclin CLN3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009360 VERSION NP_009360.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178185.1 REFERENCE 1 (residues 1 to 580) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 580) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 580) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 580) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06946. Method: conceptual translation. FEATURES Location/Qualifiers source 1..580 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..580 /product="cyclin CLN3" /calculated_mol_wt="64860" Region 35..576 /region_name="COG5024" /note="Cyclin [Cell division and chromosome partitioning]" /db_xref="CDD:227357" Site order(127,163,173..175,191,194..195) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410262" CDS 1..580 /gene="CLN3" /locus_tag="YAL040C" /gene_synonym="DAF1; FUN10; WHI1" /coded_by="NM_001178185.1:1..1743" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10611233|PMID:11792824|PMID:11509671]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:1316273]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:14573462]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /experiment="EXISTENCE:genetic interaction:GO:0007089 traversing start control point of mitotic cell cycle [PMID:2574633|PMID:2147225]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:mutant phenotype:GO:0001932 regulation of protein phosphorylation [PMID:1316273|PMID:8387915]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:11509671]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:14573462]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:2907481|PMID:3062366]" /experiment="EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:1316273|PMID:8387915]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:14573462]" /note="G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetyl-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1" /db_xref="GeneID:851191" /db_xref="SGD:S000000038" ORIGIN 1 mailkdtiir yanaryatas gtstataasv saascpnlpl llqkrraias aksknpnlvk 61 relqahhsai seynndqldh yfrlshterp lynltnfnsq pqvnpkmrfl ifdfimycht 121 rlnlststlf ltftildkys srfiiksyny qllsltalwi sskfwdsknr matlkvlqnl 181 ccnqysikqf ttmemhlfks ldwsicqsat fdsyidiflf qstsplspgv vlsapleafi 241 qqklallnna agtainksss sqgpslnine iklgaimlce lasfnlelsf kydrslialg 301 ainliklsln yynsnlweni nlaleencqd ldiklseisn tlldiamdqn sfpssfksky 361 lnsnktslak slldalqnyc iqlkleefyr sqeletmynt ifaqsfdsds ltcvysnatt 421 pksatvssaa tdyfsdhthl rrltkdsisp pfaftptsss sspspfnspy ktsssmttpd 481 sashhshsgs fsstqnsfkr slsipqnssi fwpspltptt pslmsnrkll qnlsvrskrl 541 fpvrpmatah pcsaptqlkk rstssvdcdf ndssnlkktr // LOCUS NP_009361 269 aa linear PLN 30-JUN-2025 DEFINITION holocytochrome c synthase CYC3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009361 VERSION NP_009361.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178184.1 REFERENCE 1 (residues 1 to 269) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 269) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 269) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 269) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06947. Method: conceptual translation. FEATURES Location/Qualifiers source 1..269 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..269 /product="holocytochrome c synthase CYC3" /EC_number="4.4.1.17" /calculated_mol_wt="29950" Region 1..254 /region_name="Cyto_heme_lyase" /note="Cytochrome c/c1 heme lyase; pfam01265" /db_xref="CDD:426167" CDS 1..269 /gene="CYC3" /locus_tag="YAL039C" /coded_by="NM_001178184.1:1..810" /experiment="EXISTENCE:direct assay:GO:0004408 holocytochrome-c synthase activity [PMID:3034577]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:1656231]" /experiment="EXISTENCE:direct assay:GO:0018063 cytochrome c-heme linkage [PMID:3034577]" /note="Cytochrome c heme lyase (holocytochrome c synthase); attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in mitochondrial intermembrane space; human homolog HCCS implicated in microphthalmia with linear skin defects (MLS), and can complement yeast null mutant" /db_xref="GeneID:851192" /db_xref="SGD:S000000037" ORIGIN 1 mgwfwadqkt tgkdiggaav ssmsgcpvmh esssssppss ecpvmqgdnd rinplnnmpe 61 laaskqpgqk mdlpvdrtis sipkspdsne fweypspqqm ynamvrkgki ggsgevaeda 121 vesmvqvhnf lnegcwqevl ewekphtdes hvqpkllkfm gkpgvlspra rwmhlcgllf 181 pshfsqelpf drhdwivlrg erkaeqqppt fkevryvldf yggpddengm ptfhvdvrpa 241 ldsldnakdr mtrfldrmis gpsssssap // LOCUS NP_009362 500 aa linear PLN 30-JUN-2025 DEFINITION pyruvate kinase CDC19 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009362 VERSION NP_009362.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178183.1 REFERENCE 1 (residues 1 to 500) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 500) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 500) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 500) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06948. Method: conceptual translation. FEATURES Location/Qualifiers source 1..500 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..500 /product="pyruvate kinase CDC19" /EC_number="2.7.1.40" /calculated_mol_wt="54414" Region 18..500 /region_name="Pyruvate_Kinase" /note="Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; cd00288" /db_xref="CDD:238178" Site order(20..21,78,80,88..91,179..180,186,189..193,208,216, 223,234,270,288..289,293,325,327,356,358..359,413,415,417, 428,431..432,434,436..438) /site_type="active" /note="domain interfaces [active]" /db_xref="CDD:238178" Site order(49,51,84,214,240,242,266,298) /site_type="active" /db_xref="CDD:238178" CDS 1..500 /gene="CDC19" /locus_tag="YAL038W" /gene_synonym="PYK1" /coded_by="NM_001178183.1:1..1503" /experiment="EXISTENCE:direct assay:GO:0004743 pyruvate kinase activity [PMID:12063246]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14718557|PMID:27385335]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:mutant phenotype:GO:0004743 pyruvate kinase activity [PMID:323230]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:323230]" /note="Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication" /db_xref="GeneID:851193" /db_xref="SGD:S000000036" ORIGIN 1 msrlerltsl nvvagsdlrr tsiigtigpk tnnpetlval rkaglnivrm nfshgsyeyh 61 ksvidnarks eelypgrpla ialdtkgpei rtgtttndvd ypippnhemi fttddkyaka 121 cddkimyvdy knitkvisag riiyvddgvl sfqvlevvdd ktlkvkalna gkicshkgvn 181 lpgtdvdlpa lsekdkedlr fgvkngvhmv fasfirtand vltirevlge qgkdvkiivk 241 ienqqgvnnf deilkvtdgv mvargdlgie ipapevlavq kkliaksnla gkpvicatqm 301 lesmtynprp traevsdvgn aildgadcvm lsgetakgny pinavttmae taviaeqaia 361 ylpnyddmrn ctpkptstte tvaasavaav feqkakaiiv lstsgttprl vskyrpncpi 421 ilvtrcpraa rfshlyrgvf pfvfekepvs dwtddveari nfgiekakef gilkkgdtyv 481 siqgfkagag hsntlqvstv // LOCUS NP_878040 30 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAL037C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878040 VERSION NP_878040.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184629.1 REFERENCE 1 (residues 1 to 30) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 30) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 30) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 30) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 30) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 30) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06949. Method: conceptual translation. FEATURES Location/Qualifiers source 1..30 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..30 /product="uncharacterized protein" /calculated_mol_wt="3316" CDS 1..30 /locus_tag="YAL037C-A" /coded_by="NM_001184629.1:1..93" /note="hypothetical protein" /db_xref="GeneID:1466428" /db_xref="SGD:S000028732" ORIGIN 1 msisfpkmqh livmttigdk kvnnniilfl // LOCUS NP_009363 267 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAL037W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009363 VERSION NP_009363.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178182.1 REFERENCE 1 (residues 1 to 267) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 267) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 267) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 267) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06950. Method: conceptual translation. FEATURES Location/Qualifiers source 1..267 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..267 /product="uncharacterized protein" /calculated_mol_wt="30326" CDS 1..267 /locus_tag="YAL037W" /coded_by="NM_001178182.1:1..804" /note="hypothetical protein; YAL037W has a paralog, YOR342C, that arose from the whole genome duplication" /db_xref="GeneID:851194" /db_xref="SGD:S000000035" ORIGIN 1 mdmeiedssp iddlklqkld tnvyfgpcei ltqpillqye nikfiigvnl stekiasfyt 61 qyfrnsnsvv vnlcspttaa vatkkaaidl yirnntillq kfvgqylqmg kkiktsltqa 121 qtdtiqslpq fcnsnvlsge plvqyqafnd llalfksfsh fgnilvissh sydcallkfl 181 isrvmtyypl vtiqdslqym katlnisist sdefdilndk elwefgqtqe ilkrrqtssv 241 krrcvnlpen stidnrmlmg ttkrgrf // LOCUS NP_009364 369 aa linear PLN 30-JUN-2025 DEFINITION GTP-binding protein RBG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009364 VERSION NP_009364.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178181.1 REFERENCE 1 (residues 1 to 369) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 369) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 369) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 369) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06951. Method: conceptual translation. FEATURES Location/Qualifiers source 1..369 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..369 /product="GTP-binding protein RBG1" /calculated_mol_wt="40570" Region 1..369 /region_name="Rbg1" /note="Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis]; COG1163" /db_xref="CDD:440777" CDS 1..369 /gene="RBG1" /locus_tag="YAL036C" /gene_synonym="FUN11" /coded_by="NM_001178181.1:1..1110" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:23002146]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:21076151]" /experiment="EXISTENCE:genetic interaction:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:23899355]" /note="Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid; localizes to cytosol and peroxisomes" /db_xref="GeneID:851195" /db_xref="SGD:S000000034" ORIGIN 1 msttvekika iedemartqk nkatsfhlgq lkaklaklrr elltsassgs gggagigfdv 61 artgvasvgf vgfpsvgkst llskltgtes eaaeyefttl vtvpgviryk gakiqmldlp 121 giidgakdgr grgkqviava rtcnllfiil dvnkplhhkq iiekelegvg irlnktppdi 181 likkkekggi sitntvplth lgndeiravm seyrinsaei afrcdatvdd lidvleassr 241 rympaiyvln kidslsieel ellyripnav pissgqdwnl dellqvmwdr lnlvriytkp 301 kgqipdftdp vvlrsdrcsv kdfcnqihks lvddfrnalv ygssvkhqpq yvglshiled 361 edvvtilkk // LOCUS NP_009365 1002 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF5B [Saccharomyces cerevisiae S288C]. ACCESSION NP_009365 VERSION NP_009365.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178180.1 REFERENCE 1 (residues 1 to 1002) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1002) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1002) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1002) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1002) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1002) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06952. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1002 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1002 /product="translation initiation factor eIF5B" /EC_number="3.6.5.3" /calculated_mol_wt="112138" Region 400..964 /region_name="PRK04004" /note="translation initiation factor IF-2; Validated; cl44330" /db_xref="CDD:457675" CDS 1..1002 /gene="FUN12" /locus_tag="YAL035W" /gene_synonym="yIF2" /coded_by="NM_001178180.1:1..3009" /experiment="EXISTENCE:direct assay:GO:0001732 formation of cytoplasmic translation initiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:12008673|PMID:9624054]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:17189426|PMID:12507428|PMID:19029250|PMID:16461768]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:21335519|PMID:17189426]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:9624054]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:10982835]" /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:21335519|PMID:12507428]" /experiment="EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:19029250]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:22751017]" /experiment="EXISTENCE:mutant phenotype:GO:0001732 formation of cytoplasmic translation initiation complex [PMID:12507428|PMID:17242201|PMID:17189426]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:12471154]" /experiment="EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:12507428]" /experiment="EXISTENCE:mutant phenotype:GO:0042255 ribosome assembly [PMID:22770215]" /experiment="EXISTENCE:mutant phenotype:GO:0042256 cytosolic ribosome assembly [PMID:12507428]" /note="Translation initiation factor eIF5B; GTPase that promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; promotes GTP-dependent maturation of 18S rRNA by Nob1p; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2" /db_xref="GeneID:851196" /db_xref="SGD:S000000033" ORIGIN 1 makkskknqq nywdeefeed aaqneeisat ptpnpessag addtsreasa saegaeaieg 61 dfmstlkqsk kkqekkviee kkdgkpilks kkekekekke kekqkkkeqa arkkaqqqaq 121 keknkelnkq nvekaaaeka aaeksqkskg esdkpsasak kpakkvpagl aalrrqlelk 181 kqleeqekle reeeerleke eeerlaneek mkeeakaakk ekekakrekr kaegklltrk 241 qkeekkller rraallssgn vkvaglakkd geenkpkkvv yskkkkrttq enaseaiksd 301 skkdsevvpd delkesedvl iddwenlalg dddeegtnee tqestashen edqnqgeeee 361 egeeeeeeee erahvhevak stpaatpaat ptpssaspnk kdlrspicci lghvdtgktk 421 lldkirqtnv qggeaggitq qigatyfpid aikaktkvma eyekqtfdvp gllvidtpgh 481 esfsnlrsrg sslcniailv idimhgleqq tiesikllrd rkapfvvaln kidrlydwka 541 ipnnsfrdsf akqsravqee fqsryskiql elaeqglnse lyfqnknmsk yvsivptsav 601 tgegvpdllw llleltqkrm skqlmylshv eatilevkvv egfgttidvi lsngylregd 661 rivlcgmngp ivtnirallt pqplrelrlk seyvhhkevk aalgvkiaan dlekavsgsr 721 llvvgpedde delmddvmdd ltglldsvdt tgkgvvvqas tlgslealld flkdmkipvm 781 siglgpvykr dvmkastmle kapeyavmlc fdvkvdkeae qyaeqegiki fnadviyhlf 841 dsftayqekl leerrkdfld yaifpcvlqt lqiinkrgpm iigvdvlegt lrvgtpicav 901 ktdpttkerq tlilgkvisl einhqpvqev kkgqtaagva vrledpsgqq piwgrhvden 961 dtlyslvsrr sidtlkdkaf rdqvarsdwl llkklkvvfg ie // LOCUS NP_009367 289 aa linear PLN 30-JUN-2025 DEFINITION MIND complex subunit MTW1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009367 VERSION NP_009367.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178179.1 REFERENCE 1 (residues 1 to 289) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 289) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 289) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 289) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06953. Method: conceptual translation. FEATURES Location/Qualifiers source 1..289 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..289 /product="MIND complex subunit MTW1" /calculated_mol_wt="33112" Region 11..146 /region_name="Mis12" /note="Mis12 protein; pfam05859" /db_xref="CDD:461761" CDS 1..289 /gene="MTW1" /locus_tag="YAL034W-A" /gene_synonym="DSN3; NSL2" /coded_by="NM_001178179.1:1..870" /experiment="EXISTENCE:direct assay:GO:0000444 MIS12/MIND type complex [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0000922 spindle pole [PMID:12455957]" /experiment="EXISTENCE:direct assay:GO:0007059 chromosome segregation [PMID:12455957]" /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:19893618]" /note="Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND)" /db_xref="GeneID:851197" /db_xref="SGD:S000000032" ORIGIN 1 msaptmrsts iltehlgypp islvddiina vneimykcta amekyllsks kigeedygee 61 iksgvakles llensvdknf dklelyvlrn vlripeeyld anvfrlenqk dlvivdenel 121 kkseeklrek vndvelafkk nemllkrvtk vkrllftirg fkqklnellk ckddvqlqki 181 leslkpiddt mtlltdslrk lyvdsestss teeveallqr lktngkqnnk dfrtryidir 241 tnnvlrklgl lgdkedekqs akpdartqag divsidieep qldllddvl // LOCUS NP_009368 413 aa linear PLN 30-JUN-2025 DEFINITION Fun19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009368 VERSION NP_009368.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180035.1 REFERENCE 1 (residues 1 to 413) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 413) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 413) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 413) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06954. On Oct 2, 2003 this sequence version replaced NP_009368.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..413 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..413 /product="Fun19p" /calculated_mol_wt="46937" Region 331..409 /region_name="SWIRM" /note="SWIRM domain; pfam04433" /db_xref="CDD:461307" CDS 1..413 /gene="FUN19" /locus_tag="YAL034C" /coded_by="NM_001180035.1:1..1242" /note="Non-essential hypothetical protein; expression induced in response to heat stress; FUN19 has a paralog, YOR338W, that arose from the whole genome duplication" /db_xref="GeneID:851199" /db_xref="SGD:S000002134" ORIGIN 1 mglyspesek sqlnmnyigk ddsqsifrrl nqnlkasnnn ndsnknglnm sdysnnspyg 61 rsydvrinqn sqnngngcfs gsidslvdeh iipspplspk leskishngs prmassvlvg 121 stpkgavenv lfvkpvwpng lsrkryryat ygflsqykif snlaqpyskn iinrynnlay 181 narhkyskyn ddmtppplps sssrlpspla spnlnrqary nmrkqalynn nlgkfesdte 241 wiprkrkvys pqrrtmttsp hrakkfspsa stphtniasi eaihdapqyi pnvswkklpd 301 yspplstlpt dsnkslkiew kgspmdlstd plrnelhpae lvlaqtlrlp cdlyldskrr 361 lflekvyrlk kglpfrrtda qkacridvnk asrlfqafek vgwlqdsnft kyl // LOCUS NP_009369 173 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding protein POP5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009369 VERSION NP_009369.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178178.1 REFERENCE 1 (residues 1 to 173) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 173) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 173) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 173) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06955. Method: conceptual translation. FEATURES Location/Qualifiers source 1..173 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..173 /product="RNA-binding protein POP5" /EC_number="3.1.26.5" /calculated_mol_wt="19442" Region 7..130 /region_name="RNase_P_Rpp14" /note="Rpp14/Pop5 family; pfam01900" /db_xref="CDD:460379" CDS 1..173 /gene="POP5" /locus_tag="YAL033W" /gene_synonym="FUN53" /coded_by="NM_001178178.1:1..522" /experiment="EXISTENCE:direct assay:GO:0000171 ribonuclease MRP activity [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:23700311]" /experiment="EXISTENCE:direct assay:GO:0004526 ribonuclease P activity [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9620854]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]" /note="Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs" /db_xref="GeneID:851200" /db_xref="SGD:S000000031" ORIGIN 1 mvrlksryil feiifpptdt nveesvskad illshhrasp advsiksilq eirrslslnl 61 gdygsakcns llqlkyfsnk tstgiirchr edcdlvimal mlmskigdvd glivnpvkvs 121 gtikkieqfa mrrnskilni ikcsqsshls dndfiindfk kigrenenen edd // LOCUS NP_009370 379 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein PRP45 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009370 VERSION NP_009370.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178177.1 REFERENCE 1 (residues 1 to 379) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 379) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 379) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 379) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06956. Method: conceptual translation. FEATURES Location/Qualifiers source 1..379 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..379 /product="mRNA splicing protein PRP45" /calculated_mol_wt="42352" Region 112..249 /region_name="SKIP_SNW" /note="SKIP/SNW domain; pfam02731" /db_xref="CDD:460666" CDS 1..379 /gene="PRP45" /locus_tag="YAL032C" /gene_synonym="FUN20" /coded_by="NM_001178177.1:1..1140" /experiment="EXISTENCE:curator inference:GO:0000384 first spliceosomal transesterification activity [PMID:12554883]" /experiment="EXISTENCE:curator inference:GO:0000386 second spliceosomal transesterification activity [PMID:12554883]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12359070]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:12554883]" /experiment="EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:12554883]" /experiment="EXISTENCE:direct assay:GO:0071014 post-mRNA release spliceosomal complex [PMID:12554883]" /experiment="EXISTENCE:genetic interaction:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:19016306]" /experiment="EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:19016306]" /note="Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene" /db_xref="GeneID:851201" /db_xref="SGD:S000000030" ORIGIN 1 mfsnrlpppk hsqgrvstal ssdrvepail tdqiaknvkl ddfipkrqsn felsvplptk 61 aeiqectart ksyiqrlvna klansnnras sryvtethqa panlllnnsh hievvskqmd 121 pllprfvgkk arkvvapten devvpvlhmd gsndrgeadp newkipaavs nwknpngytv 181 alerrvgkal dnenntindg fmklsealen adkkarqeir skmelkrlam eqemlakesk 241 lkelsqrary hngtpqtgai vkpkkqtstv arlkelaysq grdvsekiil gaakrseqpd 301 lqydsrfftr ganasakrhe dqvydnplfv qqdiesiykt nyekldeavn vksegasgsh 361 gpiqftkaes ddksdnyga // LOCUS NP_009371 760 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase regulator GIP4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009371 VERSION NP_009371.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178176.1 REFERENCE 1 (residues 1 to 760) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 760) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 760) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 760) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06957. Method: conceptual translation. FEATURES Location/Qualifiers source 1..760 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..760 /product="protein phosphatase regulator GIP4" /calculated_mol_wt="86505" CDS 1..760 /gene="GIP4" /locus_tag="YAL031C" /gene_synonym="FUN21" /coded_by="NM_001178176.1:1..2283" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008157 protein phosphatase 1 binding [PMID:16537909]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16537909]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:16537909]" /note="Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; protein overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate" /db_xref="GeneID:851202" /db_xref="SGD:S000000029" ORIGIN 1 mvdvqkrkkl lakaaasasi paikgsvpld sydikiiqyk nalyklneln rllnvlvphl 61 kkkrdndesy kiiplvnfil slcegpifnv spvlakryhl lcrfqlikls evqqrlstnf 121 idvegwmfpe evpldhyksc iynnslqwki lnslsciaqn aikiynaklr qillerdayk 181 arslpfdtsi iedllnpvem tlildlavli ndpvrdksth sfyklqwqvm eklnscvhsk 241 ifpilrtyyn qlqkfsetrp tslsnlqkdl phwewtlhri ytfhlrvfsv lcviisfsrq 301 iflpnkqhfl diktrlssen vyhydliice lmallspecd dvtalfelqe nlkfwtqtar 361 tdnnssrtpi fhlqpglvve lfnnhickii pklrsimgll snwmdcwkyi eknyktfdet 421 ndlrenlkek lerdkalyle vknaksklkk kpsitklpas sspspsptss aspsrqasle 481 sirtrarahl asnssrspsv spvrttfnnk naetkksvvs pekrklingr rprssslqsy 541 tnkqqtsyln strhpsiapp sklnnqrsns lqsstmtlnq kivqdtvrhl mnksastpnp 601 sassslapsp kvssinntss gkssstlian ssdtlaietl tldpesnsse lsikrvrfag 661 vppmteaenp kptkvgwykk pavlhyppip asamikplqh kskyntlrqe egftfrkslr 721 dglewenges gsettmmpfg ieikestghr iaskirsklr // LOCUS NP_009372 117 aa linear PLN 30-JUN-2025 DEFINITION SNAP receptor SNC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009372 VERSION NP_009372.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178175.1 REFERENCE 1 (residues 1 to 117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 117) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06958. Method: conceptual translation. FEATURES Location/Qualifiers source 1..117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..117 /product="SNAP receptor SNC1" /calculated_mol_wt="13070" Region <1..117 /region_name="SNC1" /note="Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]; COG5143" /db_xref="CDD:227472" CDS 1..117 /gene="SNC1" /locus_tag="YAL030W" /coded_by="NM_001178175.1:1..354" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:14981247]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:16452633]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:36125415|PMID:16452633]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:36125415|PMID:10637288]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:20059749]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0030658 transport vesicle membrane [PMID:10637288]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9195974]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:9195971]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:8374953]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11029060]" /note="Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication" /db_xref="GeneID:851203" /db_xref="SGD:S000000028" ORIGIN 1 mssstpfdpy alsehdeerp qnvqsksrta elqaeiddtv gimrdninkv aergerltsi 61 edkadnlavs aqgfkrganr vrkamwykdl kmkmclalvi iillvviivp iavhfsr // LOCUS NP_009373 1471 aa linear PLN 30-JUN-2025 DEFINITION myosin 4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009373 VERSION NP_009373.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178174.1 REFERENCE 1 (residues 1 to 1471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1471) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06959. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1471 /product="myosin 4" /calculated_mol_wt="169213" Region 2..1471 /region_name="COG5022" /note="Myosin heavy chain [General function prediction only]" /db_xref="CDD:227355" CDS 1..1471 /gene="MYO4" /locus_tag="YAL029C" /gene_synonym="FUN22; SHE1" /coded_by="NM_001178174.1:1..4416" /experiment="EXISTENCE:direct assay:GO:0000146 microfilament motor activity [PMID:11381095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:20439999|PMID:12725728]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:20439999]" /experiment="EXISTENCE:direct assay:GO:0031941 filamentous actin [PMID:11381095]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:11381095]" /experiment="EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:8625407]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:9288973|PMID:9219698|PMID:11030653]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:14691136|PMID:16890529]" /experiment="EXISTENCE:physical interaction:GO:0008298 intracellular mRNA localization [PMID:11030653|PMID:10212145]" /note="Type V myosin motor involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p; MYO4 has a paralog, MYO2, that arose from the whole genome duplication" /db_xref="GeneID:851204" /db_xref="SGD:S000000027" ORIGIN 1 msfevgtkcw yphkeqgwig gevtkndffe gtfhlelkle dgetvsietn sfendddhpt 61 lpvlrnppil estddlttls ylnepavlha ikkrymngqi ytysgivlia anpfdkvdhl 121 ysremiqnys skrkdeleph lfaiaeeayr fmvhekanqt vvvsgesgag ktvsakyimr 181 yfasvqesnn regevemsqi esqilatnpi meafgnaktt rndnssrfgk ylqilfdent 241 tirgskirty lleksrlvyq peternyhif yqileglpep vkqelhlssp kdyhytnqgg 301 qpniagidea reykittdal slvginhetq lgifkilagl lhigniemkm trndaslsse 361 eqnlqiacel lgidpfnfak wivkkqivtr sekivtnlny nqaliardsv akfiystlfd 421 wlvdninktl ydpeldqqdh vfsfigildi ygfehfekns feqfcinyan eklqqefnqh 481 vfkleqeeyv keeiewsfie fsdnqpcidl ienklgilsl ldeesrlpsg sdeswaskly 541 safnkppsne vfskprfgqt kfivshyavd veyevegfie knrdsvslgh ldvfkattnp 601 ifkqildnre lrsddapeeq ntekkimipa rlsqkkptlg smfkkslgel maiinstnvh 661 yircikpnse kkpwefdnlm vlsqlracgv letiriscag fpsrwtfdef vqryflltdy 721 slwsgilynp dlpkeaivnf cqsildatis dsakyqignt kiffkagmla fleklrtnkm 781 neiciiiqkk iraryyrlqy lqtmesikkc qsqirsllvr trvdhelktr aaillqtnir 841 alwkreyyra aigqiiklqc tckrklilds vnrkfmlmaa viiqsyirsy ghktdyrtlk 901 rssilvqsam rmqlarrryi vlqkeveern irasygigll eeaiefknsf ilnlemlnds 961 ytrltqllqg dlsnipskqr qeyetivngy ndkisklktl qveimntlnk knalkerkkk 1021 qssliqshmq slaaikgnkp srlsdevksm kqelafienv iaqdftttys ankndkvkgl 1081 giagqqvkpk lvnvirresg npdllellmd lncytlevte gylkkvnvte vngdnvlgpi 1141 hvittvvssl vrnglliqss kfiskvlltv esivmslpkd etmlggifwl snlsrlpafa 1201 anqktlyean ggdekdkltl iylndlenet lkvfdkiyst wlvkfmkhas ahieifdmvl 1261 neklfknsgd ekfaklftfl nefdavlckf qvvdsmhtki fndtlkylnv mlfndlitkc 1321 palnwkygye vdrnierlvs wfepriedvr pnliqiiqav kilqlkisnl nefkllfdfw 1381 yalnpaqiqa illkykpank geagvpneil nylanvikre nlslpgkmei mlsaqfdsak 1441 nhlrydtsai tqnsntegla tvskiikldr k // LOCUS NP_009374 528 aa linear PLN 30-JUN-2025 DEFINITION Frt2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009374 VERSION NP_009374.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178173.1 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 528) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06960. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..528 /product="Frt2p" /calculated_mol_wt="58619" Region 86..280 /region_name="Hph" /note="Sec63/Sec62 complex-interacting family; pfam13694" /db_xref="CDD:404565" CDS 1..528 /gene="FRT2" /locus_tag="YAL028W" /gene_synonym="HPH2" /coded_by="NM_001178173.1:1..1587" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15189990]" /experiment="EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:15189990]" /experiment="EXISTENCE:mutant phenotype:GO:0071472 cellular response to salt stress [PMID:15189990]" /experiment="EXISTENCE:physical interaction:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:21097665]" /note="Tail-anchored ER membrane hypothetical protein; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication" /db_xref="GeneID:851205" /db_xref="SGD:S000000026" ORIGIN 1 mqnaqiksss kgsgidgtdr nskdgvekrp ledvkqmida gtpdvghkst vetkpnvgwq 61 ashsnlaalh ekeqkyemeh hharhklhrq vipdytsast amfsdcmfna apdkvrslst 121 mkssglspkh pfnvvatfkg pfpqhsvesk pldggysakd hfpsfkmlqa qqhpahrhyk 181 dndkyglksp srsfvkdkkr lvhrflksme psssgqskds salapafdpi lpnviskpsk 241 rpthhshssd gssstqtdis lqsllyhdle sspkkhvsps rppsvasess pavanpigls 301 pkdacnasfs qssssslsss sssssstsfs qsvavdplep pgnitysssn lslnsdeldy 361 yqrhiglqlq qteallkhsl kdevlkdend lvknianfdk ivkelrdlrs rtigwkelve 421 edylmnlkqd fdkenpesfe arlsdtintn vaklqdlekr masckdrlas rkevmrkmes 481 llslenslmi skknvtfask yrnealdivf liiiivicyt fkhlvshk // LOCUS NP_009375 261 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding protein SAW1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009375 VERSION NP_009375.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178172.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 261) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06961. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..261 /product="DNA-binding protein SAW1" /calculated_mol_wt="29639" Region 1..243 /region_name="Saw1" /note="Single strand annealing-weakened 1; pfam11561" /db_xref="CDD:371605" CDS 1..261 /gene="SAW1" /locus_tag="YAL027W" /coded_by="NM_001178172.1:1..786" /experiment="EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:23299942]" /experiment="EXISTENCE:direct assay:GO:0000405 bubble DNA binding [PMID:23299942]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0070337 3'-flap-structured DNA binding [PMID:23299942]" /experiment="EXISTENCE:direct assay:GO:0070338 5'-flap-structured DNA binding [PMID:23299942]" /experiment="EXISTENCE:genetic interaction:GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends [PMID:18471978]" /experiment="EXISTENCE:mutant phenotype:GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends [PMID:18471978]" /note="5'- and 3'-flap DNA binding protein; required for recruitment of Rad1p-Rad10p to single-strand annealing intermediates with 3' non-homologous tails for removal during double-strand break repair; forms a complex with Rad1p-Rad10p and stimulates its endonuclease activity; green fluorescent protein (GFP)-fusion protein localizes to the nucleus" /db_xref="GeneID:851206" /db_xref="SGD:S000000025" ORIGIN 1 mapsiatvki ardmvlplri fvnrkqilqt ndktsnksna tifeapllsn nsiiclkspn 61 triylsqqdk knlcdeiked lllivyelas peiissvlsk irvghstdfq invlpklfag 121 adtdnavtsh iqsvtrlakf kyklhykhkw eldifinsik kianlrhylm fqtltlngfs 181 lnagpktlla rkiekqpqvp nlliengdad aldtpveedi kpviefmykp vinlgeiidv 241 hvlhrprrhk vrtqskqpqe e // LOCUS NP_009376 1355 aa linear PLN 30-JUN-2025 DEFINITION aminophospholipid-translocating P4-type ATPase DRS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009376 VERSION NP_009376.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178171.2 REFERENCE 1 (residues 1 to 1355) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1355) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1355) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1355) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06962. On Apr 26, 2011 this sequence version replaced NP_009376.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1355 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1355 /product="aminophospholipid-translocating P4-type ATPase DRS2" /EC_number="7.6.2.1" /calculated_mol_wt="153634" Region 198..1240 /region_name="ATPase-Plipid" /note="phospholipid-translocating P-type ATPase, flippase; TIGR01652" /db_xref="CDD:273734" Site order(560..562,698,721..723,788,835..837,928,931,934,954, 957) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:319770" CDS 1..1355 /gene="DRS2" /locus_tag="YAL026C" /gene_synonym="FUN38; SWA3" /coded_by="NM_001178171.2:1..4068" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:10601336|PMID:15090616|PMID:12221123]" /experiment="EXISTENCE:genetic interaction:GO:0006892 post-Golgi vesicle-mediated transport [PMID:10601336]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:16195350|PMID:12631737]" /experiment="EXISTENCE:genetic interaction:GO:0090555 phosphatidylethanolamine flippase activity [PMID:16452632]" /experiment="EXISTENCE:genetic interaction:GO:0140345 phosphatidylcholine flippase activity [PMID:16452632]" /experiment="EXISTENCE:genetic interaction:GO:0140346 phosphatidylserine flippase activity [PMID:16452632]" /experiment="EXISTENCE:mutant phenotype:GO:0006892 post-Golgi vesicle-mediated transport [PMID:10601336]" /experiment="EXISTENCE:mutant phenotype:GO:0032456 endocytic recycling [PMID:24272750]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:16452632|PMID:15249668]" /experiment="EXISTENCE:mutant phenotype:GO:0090555 phosphatidylethanolamine flippase activity [PMID:16452632]" /experiment="EXISTENCE:mutant phenotype:GO:0140346 phosphatidylserine flippase activity [PMID:8633245|PMID:16452632|PMID:15249668]" /experiment="EXISTENCE:physical interaction:GO:1990530 Cdc50p-Drs2p complex [PMID:15090616]" /note="Trans-golgi network aminophospholipid translocase (flippase); P4-type ATPase; maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network" /db_xref="GeneID:851207" /db_xref="SGD:S000000024" ORIGIN 1 mnddretppk rkpgeddtlf didflddtts hsgsrskvtn shananyipp shvlpeetid 61 ldadddnien dvhenlfmsn nhddqtswna nrfdsdayqp qslravkppg lfarfgnglk 121 naftfkrkkg pesfemnhyn avtnnelddn yldsrnkfni kilfnryilr knvgdaegng 181 eprvihinds lanssfgysd nhisttkynf atflpkflfq efskyanlff lctsaiqqvp 241 hvsptnrytt igtllvvliv samkeciedi kransdkeln nstaeifsea hddfvekrwi 301 dirvgdiirv kseepipadt iilsssepeg lcyietanld getnlkikqs rvetakfidv 361 ktlknmngkv vseqpnssly tyegtmtlnd rqiplspdqm ilrgatlrnt awifglvift 421 ghetkllrna tatpikrtav ekiinrqiia lftvlivlil issignvims tadakhlsyl 481 ylegtnkagl ffkdfltfwi lfsnlvpisl fvtvelikyy qafmigsdld lyyektdtpt 541 vvrtsslvee lgqieyifsd ktgtltrnim efkscsiagh cyidkipedk tatvedgiev 601 gyrkfddlkk klndpsdeds piindfltll atchtvipef qsdgsikyqa aspdegalvq 661 ggadlgykfi irkpnsvtvl leetgeekey qllnicefns trkrmsaifr fpdgsiklfc 721 kgadtviler lddeanqyve atmrhledya seglrtlcla mrdisegeye ewnsiyneaa 781 ttldnraekl deaanliekn liligataie dklqdgvpet ihtlqeagik iwvltgdrqe 841 tainigmscr llsedmnlli ineetrddte rnllekinal nehqlsthdm ntlalvidgk 901 slgfalepel edylltvakl ckaviccrvs plqkalvvkm vkrkssslll aigdgandvs 961 miqaahvgvg isgmegmqaa rsadiavgqf kflkklllvh gswsyqrisv ailysfyknt 1021 alymtqfwyv fanafsgqsi meswtmsfyn lfftvwppfv igvfdqfvss rllerypqly 1081 klgqkgqffs vyifwgwiin gffhsaivfi gtiliyrygf alnmhgelad hwswgvtvyt 1141 tsviivlgka alvtnqwtkf tliaipgsll fwliffpiya sifphanisr eyygvvkhty 1201 gsgvfwltli vlpifalvrd flwkyykrmy epetyhviqe mqkynisdsr phvqqfqnai 1261 rkvrqvqrmk kqrgfafsqa eeggqekivr mydttqkrgk ygelqdasan pfndnnglgs 1321 ndfesaepfi enpfadgnqn snrfsssrdd isfdi // LOCUS NP_009377 306 aa linear PLN 30-JUN-2025 DEFINITION ribosome biosynthesis protein MAK16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009377 VERSION NP_009377.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178170.2 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 306) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06963. On Apr 26, 2011 this sequence version replaced NP_009377.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..306 /product="ribosome biosynthesis protein MAK16" /calculated_mol_wt="35564" Region 1..306 /region_name="MAK16" /note="Nuclear protein with HMG-like acidic region [General function prediction only]; COG5129" /db_xref="CDD:227458" CDS 1..306 /gene="MAK16" /locus_tag="YAL025C" /coded_by="NM_001178170.2:1..921" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10838225]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16710831]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16710831]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:7739558]" /note="Essential nuclear protein; constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus" /db_xref="GeneID:851208" /db_xref="SGD:S000000023" ORIGIN 1 msdeivwqvi nqsfcshrik apngqnfcrn eynvtglctr qscplansky atvkcdngkl 61 ylymktpera htpaklweri klsknytkal qqidehllhw skffrhkckq rftkltqvmi 121 terrlalree erhyvgvapk vkrreqnrer kalvaakiek aiekelmdrl ksgaygdkpl 181 nvdekvwkki mgqmeeensq deeedwdeee esddgeveyv addgegeyvd vddlekwlad 241 sdreassase sesdsesesd sdsdeenkns akrrkkgtsa ktkrpkveie yeeehevqna 301 eqevaq // LOCUS NP_009378 1435 aa linear PLN 30-JUN-2025 DEFINITION mitotic regulator LTE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009378 VERSION NP_009378.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178169.1 REFERENCE 1 (residues 1 to 1435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1435) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06964. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1435 /product="mitotic regulator LTE1" /calculated_mol_wt="163020" Region 28..156 /region_name="RasGEFN" /note="Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; smart00229" /db_xref="CDD:214571" Site order(44,98,102..103,106,109..110,152..153,156,163) /site_type="other" /note="GTPase interaction site [polypeptide binding]" /db_xref="CDD:100121" Region 1190..1434 /region_name="RasGEF" /note="Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; cd00155" /db_xref="CDD:238087" Site order(1223..1225,1246..1247,1249..1251,1253..1254, 1257..1258,1261,1294,1297..1298,1300..1302,1304..1307, 1309..1310,1330,1333,1338..1340,1343,1358..1360,1363..1365, 1367..1369,1371..1374,1389,1393,1428,1431..1432) /site_type="other" /note="Ras interaction site [polypeptide binding]" /db_xref="CDD:238087" CDS 1..1435 /gene="LTE1" /locus_tag="YAL024C" /gene_synonym="MSI2" /coded_by="NM_001178169.1:1..4308" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12782684]" /experiment="EXISTENCE:direct assay:GO:1902480 protein localization to mitotic spindle [PMID:19948498]" /experiment="EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17121813]" /experiment="EXISTENCE:mutant phenotype:GO:0031536 positive regulation of exit from mitosis [PMID:27798238]" /experiment="EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:19948498]" /note="Protein similar to GDP/GTP exchange factors; without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures" /db_xref="GeneID:851209" /db_xref="SGD:S000000022" ORIGIN 1 meifsqkdyy ptpssnvisy esdcvskpvn sadlpalivh lssplegvdy nasadffliy 61 rnfitpqdlh dlliyrfrwc ireittnaak akrrrigeva lvrtfvllrh silnyfvqdf 121 lpnitlrlrl ieflndkhie qypkiissci inlkknwvhc sklvweniel nepdkldfda 181 wlhyslkdft qleslhkrgs rlsiyarqsf aspdfrnqsv lslyktsdvf rlpeklqssn 241 ssknqrspsm llfpdntsnv yskhriakep svdnesedms dskqkishls kvtlvstlmk 301 gvdypssyav dkimpptpak kvefilnsly ipedlneqsg tlqgtsttss ldnnsnsnsr 361 sntssmsvlh rsaigllakw mknhnrhdss ndkkfmsaik panqkpemda fvkyvvsiss 421 lnrksskeee eeflnsdssk fdilsartid evesllhlqn qliekvqths nnnrgptvnv 481 dcerrehihd ikilqqnsfk psndnfsamd nldlyqtvss iaqsvisltn tlnkqlqnne 541 snmqpspsyd alqrrkvksl ttayynkmhg sysaesmrlf dkdnsssrtd engpqrllfh 601 etdktnseai tnmtprrknh sqsqksmtss plknvlpdlk essplndsre dtesitysyd 661 selssssppr dtvtkksrkv rnivnntdsp tlktktgfln lreftfedtk sldekkstid 721 gleknydnke nqeseyestk kldnsldass eannydittr kkhsscnhki kqavvrpasg 781 risisrvqsi aitptkelsi vdpeqnksns vieeiseiep lnleynkksa lysdtsstvi 841 sistsklfes aqnsplkqtq npqrefpngt svsetnrirl siaptiesvv sdlnsittgs 901 tvetfetsrd lpvphqriin lreeyqrgnq diisntsslh elktidlsds nndlespsth 961 aknnkyffsp ddgsidvasp mknveelksk flknesetns nisgsvltmd didindtssa 1021 rntrranses aftgslnkkn lneianmldd sinddpitva lmklegtyek ipekpentks 1081 sdaigiktsk ladevemlnl nnlpsfqnsp aekrksllie rrrqtimnip ftpdqsekeg 1141 ftssspekid vsanvdvavq aaqiqeligq yrihdsrlmi snneshvpfi lmydslsvaq 1201 qmtliekeil geidwkdlld lkmkhegpqv iswlqllvrn etlsgidlai srfnltvdwi 1261 iseilltkss kmkrnviqrf ihvadhcrtf qnfntlmeii lalsssvvqk ftdawrliep 1321 gdlltweelk kipsldrnys tirnllnsvn plvgcvpfiv vylsdlsana ekkdwiledk 1381 vvnynkfdtn vqivknfiqr vqwskfytfk vnhellskcv yistltqeei nelst // LOCUS NP_009379 759 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-phosphate-mannose-protein mannosyltransferase PMT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009379 VERSION NP_009379.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178168.1 REFERENCE 1 (residues 1 to 759) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 759) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 759) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 759) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06965. On Jan 2, 2003 this sequence version replaced NP_009379.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..759 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..759 /product="dolichyl-phosphate-mannose-protein mannosyltransferase PMT2" /EC_number="2.4.1.109" /calculated_mol_wt="86739" Region 69..313 /region_name="PMT" /note="Dolichyl-phosphate-mannose-protein mannosyltransferase; pfam02366" /db_xref="CDD:396786" Region 339..531 /region_name="beta-trefoil_MIR_PMT2-like" /note="MIR domain, beta-trefoil fold, found in Saccharomyces cerevisiae dolichyl-phosphate-mannose--protein mannosyltransferase 2 (PMT2) and similar proteins; cd23284" /db_xref="CDD:467755" Site 403 /site_type="glycosylation" /note="glycosylation site [posttranslational modification]" /db_xref="CDD:467755" Site 505 /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467755" Region 550..749 /region_name="PMT_4TMC" /note="C-terminal four TMM region of protein-O-mannosyltransferase; pfam16192" /db_xref="CDD:465056" CDS 1..759 /gene="PMT2" /locus_tag="YAL023C" /gene_synonym="FUN25" /coded_by="NM_001178168.1:1..2280" /experiment="EXISTENCE:direct assay:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:21956107]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0097582 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [PMID:12551906]" /experiment="EXISTENCE:direct assay:GO:0097584 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex [PMID:12551906]" /experiment="EXISTENCE:genetic interaction:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:7852348|PMID:21956107|PMID:8543034]" /experiment="EXISTENCE:genetic interaction:GO:0032527 protein exit from endoplasmic reticulum [PMID:21147851]" /experiment="EXISTENCE:genetic interaction:GO:0035269 protein O-linked mannosylation [PMID:21231968|PMID:8543034|PMID:7852348]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:21147851]" /experiment="EXISTENCE:genetic interaction:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:21231968|PMID:23704572]" /experiment="EXISTENCE:mutant phenotype:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:7852348|PMID:8543034]" /experiment="EXISTENCE:mutant phenotype:GO:0006493 protein O-linked glycosylation [PMID:9184828]" /experiment="EXISTENCE:mutant phenotype:GO:0035269 protein O-linked mannosylation [PMID:18182384|PMID:7852348|PMID:8543034]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:18182384]" /experiment="EXISTENCE:mutant phenotype:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:23704572]" /experiment="EXISTENCE:physical interaction:GO:0097582 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [PMID:21956107|PMID:8543034]" /note="Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; functions as a heterodimer with Pmt2p but can also pair with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication" /db_xref="GeneID:851210" /db_xref="SGD:S000000021" ORIGIN 1 mssssstgys knnaahikqe ntlrqresss isvseelssa derdaedfsk ekpaaqssll 61 rlesvvmpvi ftalalftrm ykiginnhvv wdeahfgkfg syylrhefyh dvhpplgkml 121 vglsgylagy ngswdfpsge iypdyldyvk mrlfnasfsa lcvplayfta kaigfslptv 181 wlmtvlvlfe nsystlgrfi lldsmllfft vasffsfvmf hnqrskpfsr kwwkwllitg 241 islgctisvk mvglfiitmv giytvidlwt fladksmswk tyinhwlari fgliivpfci 301 fllcfkihfd llshsgtgda nmpslfqarl vgsdvgqgpr dialgssvvs iknqalggsl 361 lhshiqtypd gsnqqqvtcy gykdannewf fnrerglpsw senetdieyl kpgtsyrlvh 421 kstgrnlhth pvaapvsktq wevsgygdnv vgdnkdnwvi eimdqrgded peklhtltts 481 friknlemgc ylaqtgnslp ewgfrqqevv cmknpfkrdk rtwwniethe nerlpprped 541 fqypktnflk dfihlnlamm atnnalvpdp dkfdylassa wqwptlnvgl rlcgwgddnp 601 kyfllgtpas twassvavla fmatvvilli rwqrqyvdlr npsnwnvflm ggfypllawg 661 lhympfvims rvtyvhhylp alyfaliila ycfdaglqkw srskcgrimr fvlyagfmal 721 vigcfwyfsp isfgmegpss nfrylnwfst wdiadkqea // LOCUS NP_009380 517 aa linear PLN 30-JUN-2025 DEFINITION nucleoside transmembrane transporter FUN26 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009380 VERSION NP_009380.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178167.1 REFERENCE 1 (residues 1 to 517) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 517) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 517) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 517) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06966. Method: conceptual translation. FEATURES Location/Qualifiers source 1..517 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..517 /product="nucleoside transmembrane transporter FUN26" /calculated_mol_wt="58186" Region 81..514 /region_name="2a57" /note="Equilibrative Nucleoside Transporter (ENT); TIGR00939" /db_xref="CDD:273352" CDS 1..517 /gene="FUN26" /locus_tag="YAL022C" /coded_by="NM_001178167.1:1..1554" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:21349851|PMID:19001347|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005337 nucleoside transmembrane transporter activity [PMID:25035431|PMID:10827169]" /experiment="EXISTENCE:direct assay:GO:0015205 nucleobase transmembrane transporter activity [PMID:25035431]" /experiment="EXISTENCE:direct assay:GO:0015851 nucleobase transport [PMID:25035431]" /experiment="EXISTENCE:direct assay:GO:0015858 nucleoside transport [PMID:25035431|PMID:10827169]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:10827169]" /experiment="EXISTENCE:mutant phenotype:GO:0034257 nicotinamide riboside transmembrane transporter activity [PMID:21349851]" /experiment="EXISTENCE:mutant phenotype:GO:0034258 nicotinamide riboside transport [PMID:21349851]" /note="High affinity, broad selectivity, nucleoside/nucleobase transporter; vacuolar membrane localized transporter which may regulate the balance of nicotinamide riboside (NmR) levels between the cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis; equilibrative nucleoside transporter (ENT) family member" /db_xref="GeneID:851211" /db_xref="SGD:S000000020" ORIGIN 1 mstsadtdti kkpilavpep aladthseei srsgeehese nnehsdeegd nysereqsvs 61 tepldtlplr kklknlsyit ffaigigllw pwncilsasq yfkhdifkdt siwakiftss 121 mmsfstissm lfniylakrq ykysrrving lvweiivftv mcfftilhfl lpkwfnfmfi 181 mmlvvissmg tamtqngima ianvfgseys qgvmvgqava gvlpslvlfa lafienssvs 241 ttggillyff tttlvvticv vmfsvskisr kvnenwnved ghitdvllgs lrsneeeiri 301 vgridqmede dhrrtngtrd dndegeelql kvpfevlfak lkylvlsift tfvvtlvfpv 361 fasatyvtgl plsnaqyipl iftlwnlgdl ygrviadwpm frdqkftprk tfiysllrva 421 aiplflmfta itssssgdee hngsvivdlc ymllqflfgv tnghvismsf mkvpeqldnd 481 dekeaaggft nifvstglal gsiisyvfvf iidfiir // LOCUS NP_009381 837 aa linear PLN 30-JUN-2025 DEFINITION CCR4-NOT core exoribonuclease subunit CCR4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009381 VERSION NP_009381.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178166.1 REFERENCE 1 (residues 1 to 837) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 837) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 837) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 837) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06967. Method: conceptual translation. FEATURES Location/Qualifiers source 1..837 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..837 /product="CCR4-NOT core exoribonuclease subunit CCR4" /EC_number="3.1.13.4" /calculated_mol_wt="94539" Region <339..>439 /region_name="LRR" /note="Leucine-rich repeat (LRR) protein [Transcription]; COG4886" /db_xref="CDD:443914" Region 339..358 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 359..381 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 382..404 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 405..427 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 428..439 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 476..837 /region_name="CCR4" /note="mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]; COG5239" /db_xref="CDD:227564" Site order(511,556,665,713,715,780,817..818) /site_type="active" /note="putative catalytic site [active]" /db_xref="CDD:197306" Site order(556,817) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:197306" Site order(665,715,818) /site_type="other" /note="putative phosphate binding site [ion binding]" /db_xref="CDD:197306" CDS 1..837 /gene="CCR4" /locus_tag="YAL021C" /gene_synonym="FUN27; NUT21" /coded_by="NM_001178166.1:1..2514" /experiment="EXISTENCE:direct assay:GO:0000175 3'-5'-RNA exonuclease activity [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:18611963]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0030015 CCR4-NOT core complex [PMID:10490603]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:genetic interaction:GO:0000076 DNA replication checkpoint signaling [PMID:17158920]" /experiment="EXISTENCE:genetic interaction:GO:0000175 3'-5'-RNA exonuclease activity [PMID:11889048]" /experiment="EXISTENCE:genetic interaction:GO:0006260 DNA replication [PMID:17158920]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:11404327]" /experiment="EXISTENCE:mutant phenotype:GO:0000175 3'-5'-RNA exonuclease activity [PMID:11239395|PMID:11889048]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11889048]" /experiment="EXISTENCE:mutant phenotype:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11410650|PMID:17158920]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:11404327]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:15075273]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10490603]" /experiment="EXISTENCE:physical interaction:GO:0016593 Cdc73/Paf1 complex [PMID:9891041]" /note="Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening" /db_xref="GeneID:851212" /db_xref="SGD:S000000019" ORIGIN 1 mndpsllgyp nvgpqqqqqq qqqqhagllg kgtpnalqqq lhmnqltgip ppglmnnsdv 61 htssnnnsrq lldqlangna nmlnmnmdnn nnnnnnnnnn nnngggsgvm mnastaavns 121 igmvptvgtp vninvnasnp llhphlddps llnnpiwklq lhlaavsaqs lgqpniyarq 181 namkkylatq qaqqaqqqaq qqaqqqvpgp fgpgpqaapp alqptdfqqs hiaeaskslv 241 dctkqalmem adtltdskta kkqqptgdst psgtatnsav stpltpkiel fangkdeanq 301 allqhkklsq ysidedddie nrmvmpkdsk yddqlwhald lsnlqifnis anifkydflt 361 rlylngnslt elpaeiknls nlrvldlshn rltslpaelg scfqlkyfyf fdnmvttlpw 421 efgnlcnlqf lgvegnplek qflkilteks vtglifylrd nrpeiplphe rrfieintdg 481 epqreydslq qstehlatdl akrtftvlsy ntlcqhyatp kmyrytpswa lswdyrrnkl 541 keqilsydsd llclqevesk tfeeywvpll dkhgytgifh akaraktmhs kdskkvdgcc 601 iffkrdqfkl itkdamdfsg awmkhkkfqr tedylnramn kdnvalflkl qhipsgdtiw 661 avtthlhwdp kfndvktfqv gvlldhletl lkeetshnfr qdikkfpvli cgdfnsyins 721 avyelintgr vqihqegngr dfgymseknf shnlalkssy ncigelpftn ftpsftdvid 781 yiwfsthalr vrgllgevdp eyvskfigfp ndkfpsdhip llarfefmkt ntgskkv // LOCUS NP_009382 333 aa linear PLN 30-JUN-2025 DEFINITION Ats1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009382 VERSION NP_009382.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178165.2 REFERENCE 1 (residues 1 to 333) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 333) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 333) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 333) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06968. On Apr 26, 2011 this sequence version replaced NP_009382.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..333 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..333 /product="Ats1p" /calculated_mol_wt="36336" Region 4..301 /region_name="ATS1" /note="Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5184" /db_xref="CDD:444065" CDS 1..333 /gene="ATS1" /locus_tag="YAL020C" /gene_synonym="DPH8; FUN28; KTI13" /coded_by="NM_001178165.2:1..1002" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18466297]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0017183 protein histidyl modification to diphthamide [PMID:37662670]" /note="Protein required for modification of wobble nucleosides in tRNA; acts with Elongator complex, Kti11p, and Kti12p; has a potential role in regulatory interactions between microtubules and the cell cycle; forms a stable heterodimer with Kti11p" /db_xref="GeneID:851213" /db_xref="SGD:S000000018" ORIGIN 1 mscvyafgsn gqrqlglghd edmdtpqrsv pgddgaivrk iacggnhsvm ltndgnlvgc 61 gdnrrgelds aqalrqvhdw rpvevpapvv dvacgwdttv ivdadgrvwq rgggcyeftq 121 qhvplnsnde riavygcfqn fvvvqgtrvy gwgsntkcql qepksrslke pvlvydtgsv 181 avdyvamgkd fmvivdeggr ivhasgrlpt gfelkqqqkr hnlvvlcmwt sihlwnarln 241 tvesfgrgth sqlfpqerld fpivgvatgs ehgilttanq egkshcynvy cwgwgehgnc 301 gpqkgsqpgl qlvgqysgkp rvfggcattw ivl // LOCUS NP_009383 1131 aa linear PLN 30-JUN-2025 DEFINITION DNA-dependent ATPase FUN30 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009383 VERSION NP_009383.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178164.1 REFERENCE 1 (residues 1 to 1131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1131) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06969. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1131 /product="DNA-dependent ATPase FUN30" /EC_number="3.6.4.12" /calculated_mol_wt="128376" Region <571..1093 /region_name="HepA" /note="Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair]; COG0553" /db_xref="CDD:440319" CDS 1..1131 /gene="FUN30" /locus_tag="YAL019W" /coded_by="NM_001178164.1:1..3396" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23028372]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:39613969]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:20075079]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:20075079]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0031934 mating-type region heterochromatin [PMID:19956593]" /experiment="EXISTENCE:direct assay:GO:0140658 ATP-dependent chromatin remodeler activity [PMID:20075079|PMID:23779104]" /experiment="EXISTENCE:genetic interaction:GO:0000706 meiotic DNA double-strand break processing [PMID:39613969]" /experiment="EXISTENCE:genetic interaction:GO:1990918 double-strand break repair involved in meiotic recombination [PMID:39613969]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:23779104]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:19956593]" /experiment="EXISTENCE:mutant phenotype:GO:0000706 meiotic DNA double-strand break processing [PMID:39613969]" /experiment="EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:22960744|PMID:22960743]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:33141948|PMID:23779104|PMID:20075079]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:33141948]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:19956593]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:21388962]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:19956593]" /experiment="EXISTENCE:mutant phenotype:GO:0033120 positive regulation of RNA splicing [PMID:32234239]" /experiment="EXISTENCE:mutant phenotype:GO:0140658 ATP-dependent chromatin remodeler activity [PMID:19956593|PMID:39613969]" /experiment="EXISTENCE:mutant phenotype:GO:1990918 double-strand break repair involved in meiotic recombination [PMID:39613969]" /note="SWI/SNF-like ATP-dependent chromatin remodeler; involved in silencing at the MAT locus, telomeres and centromeres; enriched at centromeres and required to promote correct chromatin structure around centromeres and at the boundary element of silent mating type loci; recruited to DNA double-strand breaks (DSBs) where it promotes 5' strand resection; role in meiotic DSB resection and recombination; potential Cdc28p substrate" /db_xref="GeneID:851214" /db_xref="SGD:S000000017" ORIGIN 1 msgshsnded dvvqvpetss ptkvassspl kptsptvpda svaslrsrft fkpsdpsega 61 htskplpsgs pevalvnlar efpdfsqtlv qavfksnsfn lqsarerltr lrqqrqnwtw 121 nknaspkkse tpppvkkslp lantgrlssi hgninnkssk itvakqktsi fdrysnvinq 181 kqytfelptn lnidsealsk lpvnynkkrr lvradqhpig ksyessatql gsarekllan 241 rkygrhandn deeeeesmmt ddddasgddy testpqinld eqvlqfinds divdlsdlsd 301 ttmhkaqlia shrpysslna fvntnfndkd teenasnkrk rraaasanes erlldkitqs 361 irgynaiesv ikkcssygdl vtsqmkkwgv qvegdnseld lmnlgedddd dnddgnndnn 421 nsnnnntaga datskekedt kavvegfdet saeptpapap apveretkri rnttkpkvve 481 dedddvdlea iddelpqseh edddyeeede dyndeeedve yddgdddddd ddefvatrkn 541 thvisttsrn grkpivkffk gkprllspei slkdyqqtgi nwlnllyqnk msciladdmg 601 lgktcqvisf faylkqinep gphlvvvpss tlenwlrefq kfapalkiep yygslqeree 661 lrdilernag kydvivttyn laagnkydvs flknrnfnvv vydeghmlkn stserfaklm 721 kiranfrlll tgtplqnnlk elmsllefim pnlfiskkes fdaifkqrak ttddnknhnp 781 llaqeaitra ktmmkpfilr rrkdqvlkhl ppkhthiqyc elnaiqkkiy dkeiqivleh 841 krmikdgelp kdakeksklq ssssknlima lrkaslhpll frniyndkii tkmsdailde 901 payaengnke yikedmsymt dfelhklccn fpntlskyql hndewmqsgk idalkkllkt 961 iivdkqekvl ifslftqvld ilemvlstld ykflrldgst qvndrqllid kfyedkdipi 1021 filstkaggf ginlvcannv iifdqsfnph ddrqaadrah rvgqtkevni ttlitkdsie 1081 ekihqlaknk laldsyised kksqdvlesk vsdmlediiy denskpkgtk e // LOCUS NP_009384 325 aa linear PLN 30-JUN-2025 DEFINITION Lds1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009384 VERSION NP_009384.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178163.1 REFERENCE 1 (residues 1 to 325) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 325) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 325) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 325) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06970. Method: conceptual translation. FEATURES Location/Qualifiers source 1..325 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..325 /product="Lds1p" /calculated_mol_wt="36919" CDS 1..325 /gene="LDS1" /locus_tag="YAL018C" /coded_by="NM_001178163.1:1..978" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:23966878]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:23966878]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24390141]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]" /note="Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds2p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants" /db_xref="GeneID:851215" /db_xref="SGD:S000000016" ORIGIN 1 msftgslala gigglvykfg ggqsyeklpy vnipfnqyld kvykkhfskv msrtryvlmn 61 ffkdaftgga fmypfkgfle fntnkssyst tmlgilssyl imfalvsfvy watitpmyta 121 flivlgpigl fiaifhsflq anvftllfmr lshfnnhlve vcleknglee nlsevkpiky 181 yapinsiyfw ayyfpfklvk ymlglsvlfv llvisffpli gpilfhilis pfitqiyftk 241 vlrlqnfdni qrreniylha gqyasfgfla gliesvpila gfaistntig svlfnldhpm 301 vpenlvetqa eieaapqdin qqpnq // LOCUS NP_009385 1356 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase PSK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009385 VERSION NP_009385.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178162.2 REFERENCE 1 (residues 1 to 1356) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1356) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1356) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1356) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06971. On Apr 26, 2011 this sequence version replaced NP_009385.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1356 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1356 /product="serine/threonine protein kinase PSK1" /EC_number="2.7.11.1" /calculated_mol_wt="152202" Region 1095..1354 /region_name="STKc_PASK" /note="Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; cd14004" /db_xref="CDD:270906" Site order(1102..1106,1110,1123,1125,1165,1181..1184,1191,1193, 1230,1232,1234..1235,1237,1247..1248,1251,1265..1268) /site_type="active" /db_xref="CDD:270906" Site order(1102..1103,1110,1123,1125,1165,1181..1184,1189,1191, 1234..1235,1237,1247..1248) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270906" Site order(1106,1191,1193,1230,1232,1234,1251,1265..1268) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270906" Site 1247..1268 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270906" CDS 1..1356 /gene="PSK1" /locus_tag="YAL017W" /gene_synonym="FUN31" /coded_by="NM_001178162.2:1..4071" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22289182|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0060917 regulation of (1->6)-beta-D-glucan biosynthetic process [PMID:17531808]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:12372297]" /experiment="EXISTENCE:mutant phenotype:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:12372297]" /note="PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication" /db_xref="GeneID:851216" /db_xref="SGD:S000000015" ORIGIN 1 mpyigasnls ehsfvnlkek haithkgtss svaslqtpps pdqenhidne lenydtslsd 61 vstpnkkegd efeqslrdtf asfrktkppp pldfeqprlp stasssvdst vsspltdedi 121 keleflpnes thsysynpls pnslavrlri lkrsleiiiq npsmlleptp ddlpplkefa 181 grrsslprts asanhlmnrn ksqiwnttsa tlnafvnnts sssaassals nkkpgtpvfp 241 nldpthsqtf hranslaylp silpeqdpll khnnslfrgd ygnnisperp sfrqpfkdqt 301 snlrnsslln erayqedetf lphhgpsmdl lneqranlks llnllnetle kntserasdl 361 hmislfnlnk lmlgdpkknn serdkrtekl kkilldslae pffehynfig dnpiadtdel 421 keeideftgs gdttaitdir pqqdygrilr tftstknsap qaiftcsqed pwqfraandl 481 aclvfgisqn airaltlmdl ihtdsrnfvl hkllstegqe mvftgeiigi vqpetlsssk 541 vvwasfwakr kngllvcvfe kvpcdyvdvl lnlddfgaen ivdkcellsd gptlsssstl 601 slpkmasspt gskleysler kileksytkp tstenrngde nqldgdshse pslssspvrs 661 kksvkfandi kdvksisqsl aklmddvrng vvfdpdddll pmpikvcnhi netryftlnh 721 lsynipcavs stvledelkl kihslpyqag lfivdshtld ivssnksilk nmfgyhfael 781 vgksiteiip sfpkflqfin dkypalditl hknkglvlte hffrkiqaei mgdrksfyts 841 vgidglhrdg ceikidfqlr vmnskvillw vthsrdvvfe eyntnpsqlk mlkeselslm 901 ssasssasss kksssristg tlkdmsnlst yedlahrtnk lkyeigddsr ahsqstlseq 961 eqvplendkd sgemmladpe mkhklelari ysrdksqfvk egnfkvdenl iiskislsps 1021 tesladskss gkglspleee klidenaten glagspkded giimtnkrgn qpvstflrtp 1081 eknigaqkhv kkfsdfvslq kmgegaygkv nlcihkknry ivvikmifke rilvdtwvrd 1141 rklgtipsei qimatlnkkp henilrlldf fedddyyyie tpvhgetgci dlfdliefkt 1201 nmtefeakli fkqvvagikh lhdqgivhrd ikdenvivds kgfvkiidfg saayvksgpf 1261 dvfvgtidya apevlggnpy egqpqdiwai gillytvvfk enpfynidei legdlkfnna 1321 eevsedciel iksilnrcvp krptiddinn dkwlvi // LOCUS NP_009386 635 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase 2A structural subunit TPD3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009386 VERSION NP_009386.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178161.1 REFERENCE 1 (residues 1 to 635) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 635) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 635) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 635) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06972. Method: conceptual translation. FEATURES Location/Qualifiers source 1..635 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..635 /product="protein phosphatase 2A structural subunit TPD3" /calculated_mol_wt="70777" Region 39..167 /region_name="HEAT" /note="HEAT repeat [General function prediction only]; COG1413" /db_xref="CDD:441023" Region 39..63 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(55..56,59,62..63,94..95,98,101..102,105,133..134,137, 140..141,144,172..173,176,179..180,211..212,215,218..219) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 77..105 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 115..145 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 154..180 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 191..220 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 238..264 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 282..306 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 296..460 /region_name="HEAT" /note="HEAT repeat [General function prediction only]; COG1413" /db_xref="CDD:441023" Site order(298..299,302,305..306,338..339,342,345..346,349, 378..379,382,385..386,389,417..418,421,424..425,456..457, 460,463..464) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 321..349 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 360..390 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 399..425 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 436..465 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 475..504 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 514..545 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 555..580 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..635 /gene="TPD3" /locus_tag="YAL016W" /gene_synonym="FUN32" /coded_by="NM_001178161.1:1..1908" /experiment="EXISTENCE:direct assay:GO:0000159 protein phosphatase type 2A complex [PMID:8600023|PMID:17550305]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12388751]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12388751]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:12388751]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12388751]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12388751]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12388751]" /experiment="EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:17550305]" /experiment="EXISTENCE:mutant phenotype:GO:0006417 regulation of translation [PMID:10329624]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:9001215]" /note="Regulatory subunit A of the heterotrimeric PP2A complex; the heterotrimeric protein phosphatase 2A (PP2A) complex also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III" /db_xref="GeneID:851217" /db_xref="SGD:S000000014" ORIGIN 1 msgarsttag avpsaattst tsttsnskds dsneslypla llmdelkhdd ianrveamkk 61 ldtialalgp ertrnelipf ltevaqdded evfavlaeql gkfvpyiggp qyatillpvl 121 eilasaeetl vrekavdsln nvaqelsqeq lfsdfvplie hlatadwfss kvsacglfks 181 vivrikddsl rknilalylq laqddtpmvk ravgknlpil idlltqnlgl stdedwdyis 241 nifqkiindn qdsvkflavd clisilkffn akgdeshtqd llnsavklig deawrvryma 301 adrfsdlasq fssnqayide lvqpflnlce dnegdvreav akqvsgfakf lndpsiilnk 361 ilpavqnlsm desetvrsal askitnivll lnkdqvinnf lpillnmlrd efpdvrlnii 421 aslkvvndvi giellsdsll paitelakdv nwrvrmaiie yipilaeqlg mqffdqqlsd 481 lclswlwdtv ysireaavnn lkrlteifgs dwcrdeiisr llkfdlqlle nfvsrftils 541 alttlvpvvs ldvvteqllp fishladdgv pnirfnvaks yavivkvlik deakydalik 601 ntilpslqtl cqdedvdvky fakkslaecq ellkn // LOCUS NP_009387 399 aa linear PLN 30-JUN-2025 DEFINITION bifunctional N-glycosylase/AP lyase NTG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009387 VERSION NP_009387.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178160.1 REFERENCE 1 (residues 1 to 399) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 399) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 399) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 399) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06973. Method: conceptual translation. FEATURES Location/Qualifiers source 1..399 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..399 /product="bifunctional N-glycosylase/AP lyase NTG1" /EC_number="4.2.99.18" /calculated_mol_wt="45446" Region 152..312 /region_name="ENDO3c" /note="endonuclease III; smart00478" /db_xref="CDD:214684" Site order(155..157,160,208) /site_type="active" /note="minor groove reading motif [active]" /db_xref="CDD:238013" Site 237..244 /site_type="other" /note="helix-hairpin-helix signature motif" /db_xref="CDD:238013" Site order(247,303,307) /site_type="other" /note="substrate binding pocket [chemical binding]" /db_xref="CDD:238013" Site 262 /site_type="active" /db_xref="CDD:238013" CDS 1..399 /gene="NTG1" /locus_tag="YAL015C" /gene_synonym="FUN33; ogg2; SCR1" /coded_by="NM_001178160.1:1..1200" /experiment="EXISTENCE:direct assay:GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [PMID:9020769]" /experiment="EXISTENCE:direct assay:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:14500818]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19029246|PMID:24034606|PMID:10207101]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:19029246|PMID:24034606|PMID:16823961|P MID:10207101]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:8855249]" /experiment="EXISTENCE:direct assay:GO:0006284 base-excision repair [PMID:14500818]" /experiment="EXISTENCE:direct assay:GO:0006285 base-excision repair, AP site formation [PMID:9826748]" /experiment="EXISTENCE:direct assay:GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity [PMID:8855249]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:19074198]" /experiment="EXISTENCE:mutant phenotype:GO:0090297 positive regulation of mitochondrial DNA replication [PMID:19074198|PMID:17116696]" /note="DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication" /db_xref="GeneID:851218" /db_xref="SGD:S000000013" ORIGIN 1 mqkiskyssm ailrkrplvk tetgpesell pekrtkikqe evvpqpvdid wvkslpnkqy 61 fewivvrngn vpnrwatpld psilvtpast kvpykfqety armrvlrski lapvdiiggs 121 sipvtvaskc giskeqispr dyrlqvllgv mlssqtkdev tamamlnimr ycidelhsee 181 gmtleavlqi netkldelih svgfhtrkak yilstckilq dqfssdvpat inellglpgv 241 gpkmayltlq kawgkiegic vdvhvdrltk lwkwvdaqkc ktpdqtrtql qnwlpkglwt 301 eingllvgfg qiitksrnlg dmlqflppdd prssldwdlq sqlykeiqqn imsypkwvky 361 legkrelnve aeinvkheek tveetmvkle ndisvkved // LOCUS NP_009388 255 aa linear PLN 30-JUN-2025 DEFINITION syntaxin [Saccharomyces cerevisiae S288C]. ACCESSION NP_009388 VERSION NP_009388.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178159.1 REFERENCE 1 (residues 1 to 255) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 255) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 255) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 255) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06974. On Jan 2, 2003 this sequence version replaced NP_009388.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..255 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..255 /product="syntaxin" /calculated_mol_wt="28918" Region 167..236 /region_name="SNARE_SYN8" /note="SNARE motif of SYN8; cd15859" /db_xref="CDD:277212" Site order(171..174,176..178,180..182,184..185,187..192, 194..195,197..198,202..203,205..207,209..211,213..214, 216..217,220..221,223..224,226) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277212" Site 198 /site_type="other" /note="zero layer" /db_xref="CDD:277212" CDS 1..255 /gene="SYN8" /locus_tag="YAL014C" /gene_synonym="SLT2; UIP2" /coded_by="NM_001178159.1:1..768" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:12453154]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:12453154]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:12453154]" /experiment="EXISTENCE:physical interaction:GO:0006896 Golgi to vacuole transport [PMID:12453154]" /note="Endosomal SNARE related to mammalian syntaxin 8" /db_xref="GeneID:851219" /db_xref="SGD:S000000012" ORIGIN 1 mdvlklgyel dqlsdlveer trlvsvlkla ptsndnvtlk rqlgsilell qkcapndeli 61 sryntildki pdtavdkely rfqqqvarnt devskeslkk vrfknddelt vmykdddeqd 121 eesplpstht pykdeplqsq lqsqsqpqpp qpmvsnqelf inqqqqlleq dshlgalsqs 181 igrthdisld lnneivsqnd sllvdlenli dnngrnlnra srsmhgfnns rfkdngncvi 241 ilvlivvlll lllvl // LOCUS NP_009389 405 aa linear PLN 30-JUN-2025 DEFINITION Rpd3L histone deacetylase complex subunit DEP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009389 VERSION NP_009389.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178158.2 REFERENCE 1 (residues 1 to 405) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 405) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 405) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 405) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06975. On Apr 26, 2011 this sequence version replaced NP_009389.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..405 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..405 /product="Rpd3L histone deacetylase complex subunit DEP1" /calculated_mol_wt="46847" Region 182..402 /region_name="Sds3" /note="Sds3-like; pfam08598" /db_xref="CDD:430099" CDS 1..405 /gene="DEP1" /locus_tag="YAL013W" /gene_synonym="FUN54" /coded_by="NM_001178158.2:1..1218" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:36283334]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:36283334]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286007|PMID:19040720|PMID:16286008|PMID:16314178]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:24358376|PMID:16314178|PMID:8056324]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:8056324|PMID:21646424]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:19417103]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8056324|PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:1900089 negative regulation of inositol biosynthetic process [PMID:8056324]" /experiment="EXISTENCE:mutant phenotype:GO:1900090 positive regulation of inositol biosynthetic process [PMID:8056324]" /experiment="EXISTENCE:mutant phenotype:GO:1900469 negative regulation of phosphatidylserine biosynthetic process [PMID:8056324]" /experiment="EXISTENCE:mutant phenotype:GO:1900470 positive regulation of phosphatidylserine biosynthetic process [PMID:8056324]" /experiment="EXISTENCE:mutant phenotype:GO:2001246 negative regulation of phosphatidylcholine biosynthetic process [PMID:8056324]" /experiment="EXISTENCE:mutant phenotype:GO:2001247 positive regulation of phosphatidylcholine biosynthetic process [PMID:8056324]" /note="Component of the Rpd3L histone deacetylase complex; required for diauxic shift-induced histone H2B deposition onto rDNA genes; transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation; localizes to both the nucleus and mitochondria where it may play a role in mitophagy" /db_xref="GeneID:851220" /db_xref="SGD:S000000011" ORIGIN 1 msqqtpqese qttakeqdld qesvlsnidf ntdlnhnlnl seycissdag tekmdsdeek 61 slanlpelky apklsslvkq etlteslkrp hedekeaide akkmkvpgen edeskeeeks 121 qeleeaidsk ekstdardeq gdegdneeen neednenene htappalvmp spiemeeqrm 181 talkeitdie ykfaqlrqkl ydnqlvrlqt elqmclegsh pelqvyyski aairdyklhr 241 ayqrqkyels cintetiatr tfihqdfhkk vtdlrarlln rttqtwydin kerrdmdivi 301 pdvnyhvpik ldnktlscit gyasaaqlcy pgepvaedla cesieyryra npvdkleviv 361 drmrlnneis dleglrkyfh sfpgapelnp lrdseinddf hqwaq // LOCUS NP_009390 394 aa linear PLN 30-JUN-2025 DEFINITION cystathionine gamma-lyase CYS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009390 VERSION NP_009390.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178157.1 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 394) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06976. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..394 /product="cystathionine gamma-lyase CYS3" /EC_number="4.4.1.1" /calculated_mol_wt="42411" Region 10..390 /region_name="Cys_Met_Meta_PP" /note="Cys/Met metabolism PLP-dependent enzyme; pfam01053" /db_xref="CDD:395837" Site order(32..35,37..38,50,52,78..79,81,104,109,112,203,211, 213,230,240,242..243,325) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:99738" Site order(79..80,104,146,179,201,203..204,213) /site_type="active" /note="substrate-cofactor binding pocket [active]" /db_xref="CDD:99738" Site order(79..80,104,179,182,201,203..204) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99738" Site 204 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99738" CDS 1..394 /gene="CYS3" /locus_tag="YAL012W" /gene_synonym="CYI1; FUN35; STR1" /coded_by="NM_001178157.1:1..1185" /experiment="EXISTENCE:direct assay:GO:0004123 cystathionine gamma-lyase activity [PMID:1577698]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0047804 cysteine-S-conjugate beta-lyase activity [PMID:29436228]" /experiment="EXISTENCE:direct assay:GO:1904828 positive regulation of hydrogen sulfide biosynthetic process [PMID:31582588]" /experiment="EXISTENCE:mutant phenotype:GO:0004123 cystathionine gamma-lyase activity [PMID:8366024|PMID:10509018]" /experiment="EXISTENCE:mutant phenotype:GO:0019343 cysteine biosynthetic process via cystathionine [PMID:10509018]" /experiment="EXISTENCE:mutant phenotype:GO:0019344 cysteine biosynthetic process [PMID:8366024]" /experiment="EXISTENCE:mutant phenotype:GO:0019346 transsulfuration [PMID:8366024]" /note="Cystathionine gamma-lyase; catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851221" /db_xref="SGD:S000000010" ORIGIN 1 mtlqesdkfa tkaihagehv dvhgsviepi slsttfkqss panpigtyey srsqnpnren 61 leravaalen aqyglafssg sattatilqs lpqgshavsi gdvyggthry ftkvanahgv 121 etsftndlln dlpqlikent klvwietptn ptlkvtdiqk vadlikkhaa gqdvilvvdn 181 tflspyisnp lnfgadivvh satkyinghs dvvlgvlatn nkplyerlqf lqnaigaips 241 pfdawlthrg lktlhlrvrq aalsankiae flaadkenvv avnypglkth pnydvvlkqh 301 rdalgggmis frikggaeaa skfasstrlf tlaeslggie sllevpavmt hggipkeare 361 asgvfddlvr isvgiedtdd lledikqalk qatn // LOCUS NP_009391 625 aa linear PLN 30-JUN-2025 DEFINITION Swc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009391 VERSION NP_009391.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178156.1 REFERENCE 1 (residues 1 to 625) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 625) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 625) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 625) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06977. On Oct 2, 2003 this sequence version replaced NP_009391.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..625 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..625 /product="Swc3p" /calculated_mol_wt="72384" Region <211..439 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" CDS 1..625 /gene="SWC3" /locus_tag="YAL011W" /gene_synonym="SWC1" /coded_by="NM_001178156.1:1..1878" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14645854|PMID:14690608]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:14690608]" /experiment="EXISTENCE:mutant phenotype:GO:0007029 endoplasmic reticulum organization [PMID:12868057]" /note="hypothetical protein; component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae" /db_xref="GeneID:851222" /db_xref="SGD:S000000009" ORIGIN 1 mpavlrtrsk essieqkpas rtrtrsrrgk rgrddddddd deesddayde vgndydeyas 61 raklatnrpf eivaglpasv elpnynsslt hpqsiknsgv lydslvssrr twvqgemfel 121 ywrrpkkivs estpaatesp tsgtiplird kmqkmcdcvm sggphtfkvr lfilkndkie 181 qkwqdeqelk kkekelkrkn daeakrlrme erkrqqmqkk iakeqklqlq kenkakqkle 241 qealklkrke emkklkeqnk nkqgspsssm hdprmimnln lmaqedpkln tlmetvakgl 301 annsqleefk kfieiakkrs leenpvnkrp svtttrpapp skakdvaedh rlnsitlvks 361 sktaatepep kkaddenaek qqskeaktta estqvdvkke eedvkekgvk sedtqkkedn 421 qvvpkrkrrk naikedkdmq ltafqqkyvq gaeiileyle fthsryylpk ksvvefledt 481 deiiiswivi hnskeiekfk tkkikaklka dqklnkedak pgsdvekevs fnplfeadcp 541 tplytpmtmk lsgihkrfnq iirnsvspme evvkemekil qigtrlsgyn lwyqldgydd 601 ealseslrfe lnewehamrs rrhkr // LOCUS NP_009392 493 aa linear PLN 30-JUN-2025 DEFINITION Mdm10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009392 VERSION NP_009392.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178155.2 REFERENCE 1 (residues 1 to 493) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 493) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 493) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 493) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06978. On Apr 26, 2011 this sequence version replaced NP_009392.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..493 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..493 /product="Mdm10p" /calculated_mol_wt="56106" Region 1..493 /region_name="MDM10" /note="Mitochondrial distribution and morphology protein 10; pfam12519" /db_xref="CDD:432608" CDS 1..493 /gene="MDM10" /locus_tag="YAL010C" /gene_synonym="FUN37" /coded_by="NM_001178155.2:1..1482" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:8089171]" /experiment="EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:19556461]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:19556461]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:30908556]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:17410204]" /experiment="EXISTENCE:mutant phenotype:GO:0051654 establishment of mitochondrion localization [PMID:13679517]" /experiment="EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:15239954|PMID:20026336]" /experiment="EXISTENCE:mutant phenotype:GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering [PMID:19556461]" /experiment="EXISTENCE:physical interaction:GO:0001401 SAM complex [PMID:17410204]" /experiment="EXISTENCE:physical interaction:GO:0032865 ERMES complex [PMID:17410204|PMID:13679517]" /experiment="EXISTENCE:physical interaction:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:20026336]" /note="Moonlighting protein component of both the ERMES and SAM complex; subunit of the ERMES complex that acts as a molecular tether between the mitochondria and the ER, necessary for both efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex subunit that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; ERMES complex often co-localizes with peroxisomes adjacent to mitochondria-ER junctions" /db_xref="GeneID:851223" /db_xref="SGD:S000000008" ORIGIN 1 mlpymdqvlr afyqsthwst qnsyeditat srtlldfrip saihlqisnk stpntfnsld 61 fstrsrings lsylysdaqq lekfmrnstd iplqdatety rqlqpnlnfs vssantlssd 121 nttvdndkkl lhdskfvkks lyygrmyyps sdleamiikr lspqtqfmlk gvssfkesln 181 vltcyfqrds hrnlqewifs tsdllcgyrv lhnflttpsk fntslynnss lslgaefwlg 241 lvslspgcst tlryythstn tgrpltltls wnplfghiss tysaktgtns tfcakydfnl 301 ysiesnlsfg cefwqkkhhl letnknnndk lepisdelvd inpnsratkl lhenvpdlns 361 avndipstld ipvhkqklln dltyafsssl rkideersti ekfdnkinss iftsvwklst 421 slrdktlkll wegkwrgfli sagtelvftr gfqeslsdde kndnaisisa tdtengnipv 481 fpakfgiqfq yst // LOCUS NP_009393 259 aa linear PLN 30-JUN-2025 DEFINITION Nem1-Spo7 phosphatase regulatory subunit SPO7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009393 VERSION NP_009393.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178154.1 REFERENCE 1 (residues 1 to 259) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 259) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 259) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 259) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06979. Method: conceptual translation. FEATURES Location/Qualifiers source 1..259 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..259 /product="Nem1-Spo7 phosphatase regulatory subunit SPO7" /calculated_mol_wt="29983" Region 45..248 /region_name="Spo7" /note="Spo7-like protein; pfam03907" /db_xref="CDD:427580" CDS 1..259 /gene="SPO7" /locus_tag="YAL009W" /coded_by="NM_001178154.1:1..780" /experiment="EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:25359770|PMID:15889145]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9822591]" /experiment="EXISTENCE:direct assay:GO:0061709 reticulophagy [PMID:31802527]" /experiment="EXISTENCE:genetic interaction:GO:0071072 negative regulation of phospholipid biosynthetic process [PMID:15889145]" /experiment="EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:9822591]" /experiment="EXISTENCE:mutant phenotype:GO:0071071 regulation of phospholipid biosynthetic process [PMID:30201607]" /experiment="EXISTENCE:physical interaction:GO:0071595 Nem1-Spo7 phosphatase complex [PMID:9822591]" /note="Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear/ER membrane association and activation of Pah1p, a phosphatidate phosphatase involved in the production of diacylglycerol DAG for lipid droplet biogenesis; phosphatase activity of the Nem1p-Spo7p complex is inhibited by Ice2p; regulates nuclear growth by controlling phospholipid biosynthesis; required for normal nuclear envelope morphology, premeiotic replication, and sporulation" /db_xref="GeneID:851224" /db_xref="SGD:S000000007" ORIGIN 1 mepesigdvg nhaqddsasi vsgprrrsts ktssaknirn ssnispasmi frnlliledd 61 lrrqaheqki lkwqftlfla smagvgaftf yelyftsdyv kglhrvilqf tlsfisitvv 121 lfhisgqyrr tiviprrfft stnkgirqfn vklvkvqstw dekytdsvrf vsrtiaycni 181 yclkkflwlk ddnaivkfwk svtiqsqpri gavdvklvln prafsaeire gweiyrdefw 241 aregarrrkq ahelrpkse // LOCUS NP_009394 198 aa linear PLN 30-JUN-2025 DEFINITION Fun14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009394 VERSION NP_009394.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178153.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 198) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06980. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..198 /product="Fun14p" /calculated_mol_wt="21932" CDS 1..198 /gene="FUN14" /locus_tag="YAL008W" /gene_synonym="MCP3" /coded_by="NM_001178153.1:1..597" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:27226123|PMID:16407407]" /experiment="EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:27226123]" /experiment="EXISTENCE:genetic interaction:GO:0055091 phospholipid homeostasis [PMID:27226123]" /note="Integral mitochondrial outer membrane (MOM) protein; dosage suppressor of an MDM10 null that reduces ERMES-related phenotypes, such as alterations in mitochondrial morphology, protein complex assembly, and lipid profile; dosage suppressor of MDM12, MDM34, and MMM1 null mutant growth defects; novel mechanism of MOM import involving Tom70p, the TOM complex, and the TIM23 complex, requiring mitochondrial membrane potential and processing by the IMP complex for correct biogenesis" /db_xref="GeneID:851225" /db_xref="SGD:S000000006" ORIGIN 1 mtlafnmqrl vfrnlnvgkr mfknvplwrf nvanklgkpl trsvglggag ivaggfylmn 61 rqpsklifnd slgaavkqqg pleptvgnst aiteerrnki sshkqmflgs lfgvvlgvtv 121 akisilfmyv gitsmllcew lrykgwirin lkniksvivl kdvdlkklli dgllgteymg 181 fkvfftlsfv laslnank // LOCUS NP_009395 215 aa linear PLN 30-JUN-2025 DEFINITION Erp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009395 VERSION NP_009395.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178152.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 215) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06981. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..215 /product="Erp2p" /calculated_mol_wt="23933" Region 34..183 /region_name="EMP24_GP25L" /note="emp24/gp25L/p24 family/GOLD; pfam01105" /db_xref="CDD:426051" CDS 1..215 /gene="ERP2" /locus_tag="YAL007C" /coded_by="NM_001178152.1:1..648" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:mutant phenotype:GO:0006621 protein retention in ER lumen [PMID:10359606]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10359606]" /note="Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP2 has a paralog, ERP4, that arose from the whole genome duplication" /db_xref="GeneID:851226" /db_xref="SGD:S000000005" ORIGIN 1 mikstialps ffivlilalv nsvaasssya pvaislpafs keclyydmvt eddslavgyq 61 vltggnfeid fditapdgsv itsekqkkys dfllksfgvg kytfcfsnny gtalkkveit 121 lekektltde headvnnddi iannaveeid rnlnkitktl nylrarewrn mstvnstesr 181 ltwlsiliii iiavisiaqv lliqflftgr qknyv // LOCUS NP_009396 642 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family ATPase SSA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009396 VERSION NP_009396.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178151.1 REFERENCE 1 (residues 1 to 642) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 642) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 642) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 642) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06982. On Apr 9, 2007 this sequence version replaced NP_009396.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..642 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..642 /product="Hsp70 family ATPase SSA1" /calculated_mol_wt="69526" Region 4..642 /region_name="PTZ00009" /note="heat shock 70 kDa protein; Provisional" /db_xref="CDD:240227" CDS 1..642 /gene="SSA1" /locus_tag="YAL005C" /gene_synonym="YG100" /coded_by="NM_001178151.1:1..1929" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:25853343]" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:20462952]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:10745074]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:10347213]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:8755907]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:8947547]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:10347213]" /experiment="EXISTENCE:direct assay:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:8754838]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:8755907]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:18706386|PMID:7737974]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:24291094]" /experiment="EXISTENCE:direct assay:GO:0035617 stress granule disassembly [PMID:24291094]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9674429|PMID:18706386]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9789005]" /experiment="EXISTENCE:direct assay:GO:0072318 clathrin coat disassembly [PMID:23913685]" /experiment="EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:10347213]" /experiment="EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:27178214]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:11279042]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:8754838]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:27178214]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579]" /note="ATPase involved in protein folding and NLS-directed nuclear transport; HSP70 family member; required for ubiquitin-dependent degradation of short-lived proteins; forms a chaperone complex with Ydj1p; localizes to the nucleus, cytoplasm and cell wall; unique functional specificity in the propagation of yeast [URE3] prions and vacuolar-mediated degradation of gluconeogenic enzymes; general targeting factor of Hsp104p to prion fibrils; 98% identity with paralog Ssa2p" /db_xref="GeneID:851259" /db_xref="SGD:S000000004" ORIGIN 1 mskavgidlg ttyscvahfa ndrvdiiand qgnrttpsfv aftdterlig daaknqaamn 61 psntvfdakr ligrnfndpe vqadmkhfpf klidvdgkpq iqvefkgetk nftpeqissm 121 vlgkmketae sylgakvnda vvtvpayfnd sqrqatkdag tiaglnvlri ineptaaaia 181 ygldkkgkee hvlifdlggg tfdvsllsie dgifevkata gdthlggedf dnrlvnhfiq 241 efkrknkkdl stnqralrrl rtacerakrt lsssaqtsve idslfegidf ytsitrarfe 301 elcadlfrst ldpvekvlrd akldksqvde ivlvggstri pkvqklvtdy fngkepnrsi 361 npdeavayga avqaailtgd essktqdlll ldvaplslgi etaggvmtkl iprnstiptk 421 kseifstyad nqpgvliqvf egeraktkdn nllgkfelsg ippaprgvpq ievtfdvdsn 481 gilnvsavek gtgksnkiti tndkgrlske diekmvaeae kfkeedekes qriasknqle 541 siayslknti seagdkleqa dkdtvtkkae etiswldsnt taskeefddk lkelqdianp 601 imsklyqagg apggaaggap ggfpggappa peaegptvee vd // LOCUS NP_009398 206 aa linear PLN 30-JUN-2025 DEFINITION translation elongation factor 1 subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_009398 VERSION NP_009398.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178150.1 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 206) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06983. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..206 /product="translation elongation factor 1 subunit beta" /calculated_mol_wt="22496" Region <12..57 /region_name="GST_C_family" /note="C-terminal, alpha helical domain of the Glutathione S-transferase family; cl02776" /db_xref="CDD:470672" Region 123..206 /region_name="EF1_GNE" /note="EF-1 guanine nucleotide exchange domain; pfam00736" /db_xref="CDD:459919" CDS 1..206 /gene="EFB1" /locus_tag="YAL003W" /gene_synonym="TEF5" /coded_by="NM_001178150.1:1..621" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17925388]" /experiment="EXISTENCE:direct assay:GO:0032232 negative regulation of actin filament bundle assembly [PMID:19095653]" /experiment="EXISTENCE:genetic interaction:GO:0006449 regulation of translational termination [PMID:19545407]" /experiment="EXISTENCE:mutant phenotype:GO:0005853 eukaryotic translation elongation factor 1 complex [PMID:8420802]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:10409717]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:10409717]" /note="Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site; human homolog EEF1B2 can complement yeast efb1 mutants" /db_xref="GeneID:851260" /db_xref="SGD:S000000003" ORIGIN 1 mastdfskie tlkqlnasla dksyiegtav sqadvtvfka fqsaypefsr wfnhiaskad 61 efdsfpaasa aaaeeeeddd vdlfgsddee adaeaeklka eriaaynakk aakpakpaak 121 sivtldvkpw ddetnleemv anvkaiemeg ltwgahqfip igfgikklqi ncvveddkvs 181 lddlqqsiee dedhvqstdi aamqkl // LOCUS NP_009399 1274 aa linear PLN 30-JUN-2025 DEFINITION CORVET complex membrane-binding subunit VPS8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009399 VERSION NP_009399.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178149.1 REFERENCE 1 (residues 1 to 1274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1274) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06984. On Feb 2, 2004 this sequence version replaced NP_009399.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1274 /product="CORVET complex membrane-binding subunit VPS8" /calculated_mol_wt="144832" Region 538..735 /region_name="Vps8" /note="Golgi CORVET complex core vacuolar protein 8; pfam12816" /db_xref="CDD:463718" Region 1197..1266 /region_name="RING-H2_Vps" /note="RING finger, H2 subclass, found in vacuolar protein sorting-associated proteins Vps8, Vps11, Vps18, Vps41, and similar proteins; cd16484" /db_xref="CDD:438147" CDS 1..1274 /gene="VPS8" /locus_tag="YAL002W" /gene_synonym="FUN15; VPL8; VPT8" /coded_by="NM_001178149.1:1..3825" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:19828734]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:8969229]" /experiment="EXISTENCE:direct assay:GO:0033263 CORVET complex [PMID:17488625]" /experiment="EXISTENCE:direct assay:GO:0051020 GTPase binding [PMID:19828734]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:20173035]" /experiment="EXISTENCE:mutant phenotype:GO:0007009 plasma membrane organization [PMID:39002672]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:19828734]" /experiment="EXISTENCE:mutant phenotype:GO:0043495 protein-membrane adaptor activity [PMID:19828734]" /experiment="EXISTENCE:physical interaction:GO:0051020 GTPase binding [PMID:19828734]" /note="Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif" /db_xref="GeneID:851261" /db_xref="SGD:S000000002" ORIGIN 1 meqngldhds rssidttind tqktflefrs ytqlseklas sssytappln edgpkgvasa 61 vsqgsesvvs wttlthvysi lgayggptcl yptatyflmg tskgcvlifn ynehlqtilv 121 ptlsedpsih sirspvksiv icsdgthvaa syetgniciw nlnvgyrvkp tseptngmtp 181 tpalpavlhi ddhvnkeitg ldffgarhta livsdrtgkv slyngyrrgf wqlvynskki 241 ldvnsskekl irsklsplis rekistnlls vlttthfali llsphvslmf qetvepsvqn 301 slvvnssisw tqncsrvays vnnkisvisi sssdfnvqsa shspefaesi lsiqwidqll 361 lgvltishqf lvlhpqhdfk illrldflih dlmippnkyf visrrsfyll tnysfkigkf 421 vswsditlrh ilkgdylgal efiesllqpy cplanllkld nnteertkql mepfynlsla 481 alrflikkdn adynrvyqll mvvvrvlqqs skkldsipsl dvfleqglef felkdnavyf 541 evvanivaqg svtsispvlf rsiidyyake enlkviedli imlnpttldv dlavklcqky 601 nlfdlliyiw nkifddyqtp vvdliyrisn qsekcvifng pqvppettif dyvtyiltgr 661 qypqnlsisp sdkcskiqre lsafifsgfs ikwpsnsnhk lyicenpeee pafpyfhlll 721 ksnpsrflam lnevfeaslf nddndmvasv geaelvsrqy vidllldamk dtgnsdnirv 781 lvaifiatsi skypqfikvs nqaldcvvnt icssrvqgiy eisqialesl lpyyhsrtte 841 nfilelkekn fnkvlfhiyk senkyasals liletkdiek eyntdivsit dyilkkcppg 901 slecgkvtev ietnfdllls rigiekcvti fsdfdynlhq eilevkneet qqkyldklfs 961 tpninnkvdk rlrnlhieln ckykskremi lwlngtvlsn aeslqildll nqdsnfeaaa 1021 iiherlesfn lavrdllsfi eqclnegktn istlleslrr afddcnsagt ekkscwilli 1081 tflitlygky pshderkdlc nkllqeaflg lvrsksssqk dsggefweim ssvlehqdvi 1141 lmkvqdlkql llnvfntykl erslseliqk iiedssqdlv qqyrkflseg wsihtddcei 1201 cgkkiwgagl dpllflawen vqrhqdmisv dlktplvifk chhgfhqtcl enlaqkpdey 1261 sclicqtesn pkiv // LOCUS NP_009400 1160 aa linear PLN 30-JUN-2025 DEFINITION transcription factor TFIIIC subunit TFC3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009400 VERSION NP_009400.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178148.1 REFERENCE 1 (residues 1 to 1160) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1160) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1160) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06985. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1160 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1160 /product="transcription factor TFIIIC subunit TFC3" /calculated_mol_wt="131978" Region 107..175 /region_name="B-block_TFIIIC" /note="B-block binding subunit of TFIIIC; pfam04182" /db_xref="CDD:367858" Region 549..639 /region_name="Tau138_eWH" /note="extended winged-helix domain of tau138 and related proteins; cd16169" /db_xref="CDD:320085" Region 732..1115 /region_name="DUF6581" /note="Family of unknown function (DUF6581); pfam20222" /db_xref="CDD:466373" CDS 1..1160 /gene="TFC3" /locus_tag="YAL001C" /gene_synonym="FUN24; TSV115" /coded_by="NM_001178148.1:1..3483" /experiment="EXISTENCE:direct assay:GO:0000127 transcription factor TFIIIC complex [PMID:2180956|PMID:1279682|PMID:2002052|PMID:1474578]" /experiment="EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2404611|PMID:2649882]" /experiment="EXISTENCE:direct assay:GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding [PMID:2404611]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:3633923|PMID:2183033|PMID:8464480]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2002052]" /experiment="EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2183033]" /experiment="EXISTENCE:mutant phenotype:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:8083243]" /experiment="EXISTENCE:mutant phenotype:GO:0071168 protein localization to chromatin [PMID:18708580]" /note="Subunit of RNA polymerase III transcription initiation factor complex; part of TauB domain of TFIIIC that binds DNA at BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding; largest of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); colocalizes with condensin at pol III genes and several ETC (extra TFIIIC) sites; may have a role in recruiting or stabilizing Scc2/4 and condensin on chromosomes" /db_xref="GeneID:851262" /db_xref="SGD:S000000001" ORIGIN 1 mvltiypdel vqivsdkias nkgkitlnql wdisgkyfdl sdkkvkqfvl scvilkkdie 61 vycdgaittk nvtdiigdan hsysvgited slwtlltgyt kkestignsa felllevaks 121 gekgintmdl aqvtgqdprs vtgrikkinh lltssqliyk ghvvkqlklk kfshdgvdsn 181 pyinirdhla tivevvkrsk ngirqiidlk relkfdkekr lskafiaaia wldekeylkk 241 vlvvspknpa ikircvkyvk dipdskgsps feydsnsade dsvsdskaaf ededlvegld 301 nfnatdllqn qglvmeeked avknevllnr fyplqnqtyd iadksglkgi stmdvvnrit 361 gkefqraftk sseyylesvd kqkentggyr lfriydfegk kkffrlftaq nfqkltnaed 421 eisvpkgfde lgksrtdlkt lnednfvaln ntvrfttdsd gqdiffwhge lkippnskkt 481 pnknkrkrqv knstnasvag nisnpkrikl eqhvstaqep ksaedspssn ggtvvkgkvv 541 nfggfsarsl rslqrqrail kvmntiggva ylreqfyesv skymgstttl dkktvrgdvd 601 lmveseklga rtepvsgrki iflptvgeda iqryilkekd skkatftdvi hdteiyffdq 661 teknrfhrgk ksverirkfq nrqknakika sddaiskkst svnvsdgkik rrdkkvsagr 721 ttvvventke dktvyhagtk dgvqalirav vvtksiknei mwdkitklfp nnsldnlkkk 781 wtarrvrmgh sgwrayvdkw kkmlvlaiks ekislrdvee ldliklldiw tsfdekeikr 841 plflyknyee nrkkftlvrd dtlthsgndl amssmiqrei sslkktytrk isastkdlsk 901 sqsddyirtv irsiliesps ttrneiealk nvgnesidnv imdmakekqi ylhgsklect 961 dtlpdilenr gnykdfgvaf qyrckvnell eagnaivinq epsdisswvl idlisgelln 1021 mdvipmvrnv rpltytsrrf eirtltppli iyansqtkln tarksavkvp lgkpfsrlwv 1081 ngsgsirpni wkqvvtmvvn eiifhpgitl srlqsrcrev lslheiseic kwllerqvli 1141 ttdfdgywvn hnwysiyest // LOCUS NP_009401 539 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin NUP60 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009401 VERSION NP_009401.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178209.1 REFERENCE 1 (residues 1 to 539) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 539) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 539) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 539) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06986. Method: conceptual translation. FEATURES Location/Qualifiers source 1..539 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..539 /product="FG-nucleoporin NUP60" /calculated_mol_wt="58908" CDS 1..539 /gene="NUP60" /locus_tag="YAR002W" /coded_by="NM_001178209.1:1..1620" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17897934]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:10684247]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:11387327]" /experiment="EXISTENCE:genetic interaction:GO:0060188 regulation of protein desumoylation [PMID:17403926]" /experiment="EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20098417|PMID:20932479|PMID:21036941]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:17538013]" /experiment="EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:11535617]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:11535617]" /experiment="EXISTENCE:mutant phenotype:GO:0006913 nucleocytoplasmic transport [PMID:11535617]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:21036941]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:12411502|PMID:21036941]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:17418788]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:21818277]" /experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:21818277|PMID:11862215]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:21818277]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788]" /note="FG-nucleoporin component of the nuclear pore complex central core; direct role in nucleocytoplasmic transport and maintenance of the NPC permeability barrier; role in gene tethering at the nuclear periphery; short linear motifs connect Mlp1p and the Y-complex via Nup85p to facilitate nuclear basket docking onto the core of the NPC; Cdc5p-mediated phosphorylation leads to detachment and reattachment of the basket during meiosis; both NUP1 and NUP60 are human NUP153 homologs" /db_xref="GeneID:851263" /db_xref="SGD:S000000063" ORIGIN 1 mhrkslrras atvpsapyrk qiisnahnkp slfskiktff tqkdsarvsp rnnvankqpr 61 nesfnrriss mpggyfhsei spdstvnrsv vvsavgearn dienkeeeyd ethetnisna 121 klanffskkg neplseieie gvmsllqkss ksmitsegeq ksaegnnidq slilkesgst 181 pisisnaptf npkydtsnas mnttlgsigs rkysfnyssl pspykttvyr ysaakkipdt 241 ytantsaqsi asaksvrsgv sksapskkis ntaaalvsll dendskknna aselanpyss 301 yvsqirkhkr vspnaaprqe iseeettvkp lfqnvpeqge epmkqlnatk ispsapskds 361 ftkykparss slrsnvvvae tspekkdggd kppssafnfs fntsrnvept enayksenap 421 sasskefnft nlqakplvgk pkteltkgds tpvqpdlsvt pqkssskgfv fnsvqkksrs 481 nlsqendneg khisasidnd fseekaeefd fnvpvvskql gnglvdenkv eafkslytf // LOCUS NP_009402 219 aa linear PLN 30-JUN-2025 DEFINITION Erp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009402 VERSION NP_009402.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180033.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 219) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06987. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..219 /product="Erp1p" /calculated_mol_wt="24592" Region 22..213 /region_name="EMP24_GP25L" /note="emp24/gp25L/p24 family/GOLD; pfam01105" /db_xref="CDD:426051" CDS 1..219 /gene="ERP1" /locus_tag="YAR002C-A" /coded_by="NM_001180033.1:1..660" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:mutant phenotype:GO:0006621 protein retention in ER lumen [PMID:10359606]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10359606]" /experiment="EXISTENCE:physical interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11157978]" /note="Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication" /db_xref="GeneID:851264" /db_xref="SGD:S000002129" ORIGIN 1 mlltsllqvf acclvlpaqv tafyyytsga erkcfhkels kgtlfqatyk aqiyddqlqn 61 yrdagaqdfg vlidieetfd dnhlvvhqkg sasgdltfla sdsgehkici qpeaggwlik 121 aktkidvefq vgsdekldsk gkatidilha kvnvlnskig eirreqklmr dreatfrdas 181 eavnsramww iviqlivlav tcgwqmkhlg kffvkqkil // LOCUS NP_009403 426 aa linear PLN 30-JUN-2025 DEFINITION COMPASS subunit protein SWD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009403 VERSION NP_009403.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178210.1 REFERENCE 1 (residues 1 to 426) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 426) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 426) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 426) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06988. Method: conceptual translation. FEATURES Location/Qualifiers source 1..426 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..426 /product="COMPASS subunit protein SWD1" /calculated_mol_wt="48524" Region 10..341 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(15,43,47,53..54,70..71,89,93,99..100,113,130,148, 154..155,168,186,194,199..200,212..213,231,235,241..242, 265..266,283,288,297..298,310..311,329,334,340..341) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 31..63 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 76..113 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 117..167 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 174..205 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 217..257 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 264..309 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 316..340 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..426 /gene="SWD1" /locus_tag="YAR003W" /gene_synonym="CPS50; FUN16; SAF49" /coded_by="NM_001178210.1:1..1281" /experiment="EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11805083|PMID:11742990]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:11742990]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11687631]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11687631|PMID:11805083|PMID:11752412]" /experiment="EXISTENCE:mutant phenotype:GO:0042800 histone H3K4 methyltransferase activity [PMID:11805083|PMID:11752412]" /experiment="EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11742990|PMID:11752412|PMID:11687631]" /note="Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7" /db_xref="GeneID:851265" /db_xref="SGD:S000000064" ORIGIN 1 mnillqdpfa vlkehpeklt htienplrte clqfspcgdy lalgcangal viydmdtfrp 61 icvpgnmlga hvrpitsiaw spdgrlllts srdwsiklwd lskpskplke irfdspiwgc 121 qwldakrrlc vatifeesda yvidfsndpv asllsksdek qlsstpdhgy vlvctvhtkh 181 pniiivgtsk gwldfykfhs lyqtecihsl kitssnikhl ivsqngerla incsdrtirq 241 yeisiddens aveltlehky qdvinklqwn cilfsnntae ylvasthgss ahelyiwett 301 sgtlvrvleg aeeelidinw dfysmsivsn gfesgnvyvw svvippkwsa lapdfeevee 361 nvdylekede fdevdeaeqq qgleqeeeia idlrtreqyd vrgnnllver ftiptdytri 421 ikmqss // LOCUS NP_009404 621 aa linear PLN 30-JUN-2025 DEFINITION replication factor A subunit protein RFA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009404 VERSION NP_009404.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178211.1 REFERENCE 1 (residues 1 to 621) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 621) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 621) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 621) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 621) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 621) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06989. Method: conceptual translation. FEATURES Location/Qualifiers source 1..621 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..621 /product="replication factor A subunit protein RFA1" /calculated_mol_wt="70217" Region 3..617 /region_name="rpa1" /note="replication factor-a protein 1 (rpa1); TIGR00617" /db_xref="CDD:273177" CDS 1..621 /gene="RFA1" /locus_tag="YAR007C" /gene_synonym="BUF2; FUN3; RPA1; RPA70" /coded_by="NM_001178211.1:1..1866" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9679065]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:7761422]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:8804316]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005662 DNA replication factor A complex [PMID:2554144]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006260 DNA replication [PMID:2554144]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]" /experiment="EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:8910442]" /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:12226081]" /experiment="EXISTENCE:direct assay:GO:0032079 positive regulation of endodeoxyribonuclease activity [PMID:34764291]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:7761422]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:17202155]" /experiment="EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:9679065]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:14702040]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:7969128]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:7969128]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:7969128]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:12072452]" /experiment="EXISTENCE:mutant phenotype:GO:0010833 telomere maintenance via telomere lengthening [PMID:22354040]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:18342608]" /experiment="EXISTENCE:mutant phenotype:GO:0032079 positive regulation of endodeoxyribonuclease activity [PMID:34764291]" /experiment="EXISTENCE:physical interaction:GO:0007004 telomere maintenance via telomerase [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0016567 protein ubiquitination [PMID:18342608]" /experiment="EXISTENCE:physical interaction:GO:0045184 establishment of protein localization [PMID:2554144]" /note="Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved ssDNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; promotes recruitment, helicase and nuclease activities of Dna2p; role in DNA catenation/decatenation pathway of chromosome disentangling; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:851266" /db_xref="SGD:S000000065" ORIGIN 1 mssvqlsrgd fhsiftnkqr ydnptggvyq vyntrksdga nsnrknlimi sdgiyhmkal 61 lrnqaaskfq smelqrgdii rviiaepaiv rerkkyvllv ddfelvqsra dmvnqtstfl 121 dnyfsehpne tlkdeditds gnvanqtnas nagvpdmlhs nsnlnanerk fanenpnsqk 181 trpifaieql spyqnvwtik arvsykgeik twhnqrgdgk lfnvnfldts geiratafnd 241 fatkfneilq egkvyyvska klqpakpqft nlthpyelnl drdtvieecf desnvpkthf 301 nfikldaiqn qevnsnvdvl giiqtinphf eltsragkkf drrditivdd sgfsisvglw 361 nqqaldfnlp egsvaaikgv rvtdfggksl smgfsstlip npeipeayal kgwydskgrn 421 anfitlkqep gmggqsaasl tkfiaqriti araqaenlgr sekgdffsvk aaisflkvdn 481 faypacsnen cnkkvleqpd gtwrcekcdt nnarpnwryi ltisiidetn qlwltlfddq 541 akqllgvdan tlmslkeedp neftkitqsi qmneydfrir aredtyndqs rirytvanlh 601 slnyraeady ladelskall a // LOCUS NP_009405 275 aa linear PLN 30-JUN-2025 DEFINITION tRNA splicing endonuclease subunit SEN34 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009405 VERSION NP_009405.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178212.1 REFERENCE 1 (residues 1 to 275) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 275) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 275) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 275) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06990. Method: conceptual translation. FEATURES Location/Qualifiers source 1..275 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..275 /product="tRNA splicing endonuclease subunit SEN34" /EC_number="4.6.1.16" /calculated_mol_wt="31182" Region 94..272 /region_name="endA" /note="tRNA-intron lyase; TIGR00324" /db_xref="CDD:129424" CDS 1..275 /gene="SEN34" /locus_tag="YAR008W" /gene_synonym="FUN4" /coded_by="NM_001178212.1:1..828" /experiment="EXISTENCE:direct assay:GO:0000213 tRNA-intron lyase activity [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0000214 tRNA-intron endonuclease complex [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0000379 tRNA-type intron splice site recognition and cleavage [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0000213 tRNA-intron lyase activity [PMID:9200603]" /experiment="EXISTENCE:mutant phenotype:GO:0000379 tRNA-type intron splice site recognition and cleavage [PMID:9200603]" /note="Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease" /db_xref="GeneID:851267" /db_xref="SGD:S000000066" ORIGIN 1 mpplvfdidh ikllrkwgic gvlsgtlpta aqqnvflsvp lrlmledvlw lhlnnladvk 61 lirqegdeim egitlergak lskivndrln ksfeyqrkfk kdehiaklkk igrindktta 121 eelqrldkss nndqliessl fidiantsmi lrdirsdsds lsrddisdll fkqyrqagkm 181 qtyflykalr dqgyvlspgg rfggkfiayp gdplrfhshl tiqdaidyhn epidlismis 241 garlgttvkk lwviggvaee tkethffsie wagfg // LOCUS NP_009406 1196 aa linear PLN 30-JUN-2025 DEFINITION truncated gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009406 VERSION NP_009406.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178213.1 REFERENCE 1 (residues 1 to 1196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1196) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06991. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1196 /product="truncated gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="136602" Region 105..206 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 706..>894 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1047..1183 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1051..1054,1088..1090,1093,1126,1153,1180) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1196 /locus_tag="YAR009C" /coded_by="NM_001178213.1:1..3591" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /note="Retrotransposon TYA Gag and TYB Pol genes; Gag processing produces capsid proteins, Pol is cleaved to produce protease, reverse transcriptase and integrase activities; in YARCTy1-1 TYB is mutant and probably non-functional; protein product forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:851268" /db_xref="SGD:S000000067" ORIGIN 1 metftgylks tcfhqispyp psimsiqvkv hanililsfi eclrmpmhrq iryslknnti 61 tyfnesdvdw ssaidyqcpd cligkstkhr hikgsrlkyq nsyepfqylh tdifgpvhnl 121 pksapsyfis ftdettklrw vyplhdrred sildvfttil afiknqfqas vlviqmdrgs 181 eytnrtlhkf lekngitpcy tttadsrahg vaerlnrtll ddcrtqlqcs glpnhlwfsa 241 iefstivrns laspkskksa rqhaglagld istllpfgqp vivndhnpns kihprgipgy 301 alhpsrnsyg yiiylpslkk tvdttnyvil qgkesrldqf nydaltfded lnrltasyhs 361 fiasneiqes ndlniesdhd fqsdielhpe qprnvlskav sptdstppst htedskrvsk 421 tniraprevd pnisesnilp skkrsstpqi sniestgsgg mhklnvplla pmsqsnthes 481 shaskskdfr hsdsysenet nhtnvpisst ggtnnktvpq isdqetekri ihrspsidas 541 ppennsshni vpiktpttvs eqnteesiia dlplpdlppe sptefpdpfk elppinshqt 601 nsslggigds nayttinskk rslednetei kvsrdtwntk nmrslepprs kkrihliaav 661 kavksikpir ttlrydeait ynkdikekek yieayhkevn qllkmntwdt dkyydrkeid 721 pkrvinsmfi fnkkrdgthk arfvargdiq hpdtydtgmq sntvhhyalm tslslaldnn 781 yyitqldiss aylyadikee lyirppphlg mndklirlkk slyglkqsga nwyetiksyl 841 ikqcgmeevr gwscvfknsq vticlfvddm ilfskdlnan kkiittlkkq ydtkiinlge 901 sdneiqydil gleikyqrgk ymklgmeksl teklpklnvp lnpkgkklra pgqpglyidq 961 deleidedey kekvhemqkl iglasyvgyk frfdllyyin tlaqhilfps rqvldmtyel 1021 iqfmwdtrdk qliwhknkpt epdnklvais dasygnqpyy ksqigniyll ngkviggkst 1081 kasltctstt eaeihaises vpllnnlsyl iqelnkkpii kglltdsrst isiikstnee 1141 kfrnrffgtk amrlrdevsg nnlyvyyiet kkniadvmtk plpiktfkll tnkwih // LOCUS NP_009407 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009407 VERSION NP_009407.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178214.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 440) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06992. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..440 /product="gag protein" /calculated_mol_wt="48941" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YAR010C" /coded_by="NM_001178214.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; Gag processing produces capsid proteins; in YARCTy1-1 TYB is mutant and probably non-functional" /db_xref="GeneID:851269" /db_xref="SGD:S000000068" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqtaqshsp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_009408 709 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase regulator BUD14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009408 VERSION NP_009408.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178215.2 REFERENCE 1 (residues 1 to 709) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 709) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 709) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 709) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06993. On Apr 26, 2011 this sequence version replaced NP_009408.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..709 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..709 /product="protein phosphatase regulator BUD14" /calculated_mol_wt="78851" Region 266..312 /region_name="SH3_1" /note="SH3 domain; pfam00018" /db_xref="CDD:394975" Site order(268,270,273,277,295..296,311,313..314) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212783" CDS 1..709 /gene="BUD14" /locus_tag="YAR014C" /coded_by="NM_001178215.2:1..2130" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11452010]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11452010]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11452010]" /experiment="EXISTENCE:direct assay:GO:0006355 regulation of DNA-templated transcription [PMID:15601868]" /experiment="EXISTENCE:direct assay:GO:0019888 protein phosphatase regulator activity [PMID:16107882]" /experiment="EXISTENCE:direct assay:GO:0030837 negative regulation of actin filament polymerization [PMID:19217430]" /experiment="EXISTENCE:direct assay:GO:0032880 regulation of protein localization [PMID:19217430]" /experiment="EXISTENCE:direct assay:GO:1990615 Kelch-containing formin regulatory complex [PMID:24828508]" /experiment="EXISTENCE:genetic interaction:GO:0008360 regulation of cell shape [PMID:12477789]" /experiment="EXISTENCE:genetic interaction:GO:0030837 negative regulation of actin filament polymerization [PMID:19217430]" /experiment="EXISTENCE:genetic interaction:GO:0032465 regulation of cytokinesis [PMID:24828508]" /experiment="EXISTENCE:genetic interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:24828508]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:34633288]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:15601868]" /experiment="EXISTENCE:mutant phenotype:GO:0007010 cytoskeleton organization [PMID:16107882]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:16107882]" /experiment="EXISTENCE:mutant phenotype:GO:0030837 negative regulation of actin filament polymerization [PMID:19217430]" /experiment="EXISTENCE:mutant phenotype:GO:0060627 regulation of vesicle-mediated transport [PMID:24828508]" /experiment="EXISTENCE:mutant phenotype:GO:1905047 mitotic spindle pole body organization [PMID:39296336]" /note="Protein phosphatase regulator; subunit of the Bud14p-Glc7p complex that localizes Glc7p to the cell cortex where it activates the dynein/dynactin complex; subunit of the KFRC complex with Kel1p and Kel2p that regulates Bnr1p (formin) to control actin cable assembly, cytokinesis, and polarized growth; involved in spindle pole body size maintenance; involved in bud-site selection; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:851271" /db_xref="SGD:S000000069" ORIGIN 1 msnkeehvde tsasgvkevs siaarhdngy apslitstsg mdsfqshall ndptliedys 61 diinnrptsg skltlgneds esmggsvvvt ptsnksspfn sklnilsnaa ekghdvlrnr 121 dddkeleeen vekhmhsnsk rdqrhykens selpdsydys dsefednler rlqeietdsv 181 dsadkdevhf svnntmnpdv ddfsdglkya isededeeen ysddddfdrk fqdsgfqgek 241 ddleeenddy qplsppreld pdklyalyaf nghdsshcql gqdepcilln dqdaywwlvk 301 ritdgkigfa paeiletfpe rlarlncwkn enmssqsvas sdskddsiss gnknqsdaes 361 iiptpalngy gkgnksvsfn dvvgyadrfi ddaiedtsld snddggegng qsydddvdnd 421 ketkvthrde yteaklnfgk fqdddtsdvv sdvsfstsln tplnvkkvrr qdnknesepk 481 tssskdredd ynanryvgqe ksepvdsdyd tdlkkvfeap rmpfangmak sdsqnslsti 541 gefspsssew tnespstpiv eesssipssr aikdisqyih akskieettn ventegqiqa 601 slgssggman qtdaeqpkee lekhhstpee ekqstlslhs sseedfymde qravssasin 661 sslsgsrals ntnmsdpask pnslvqhlya pvfdrmdvlm kqldeiirk // LOCUS NP_009409 306 aa linear PLN 30-JUN-2025 DEFINITION phosphoribosylaminoimidazolesuccinocarboxamide synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009409 VERSION NP_009409.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178216.1 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 306) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06994. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..306 /product="phosphoribosylaminoimidazolesuccinocarboxamide synthase" /EC_number="6.3.2.6" /calculated_mol_wt="34472" Region 1..305 /region_name="PRK13961" /note="phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional" /db_xref="CDD:237571" Site order(15..16,18..19,21,23..24,31,33,75,110,112,114,164,219, 232..233) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:133469" Site order(16,18..21,23,31,43,76,109..112,114,118,120,122, 126..128,162,164,171,215..217,219,233,239..242) /site_type="active" /db_xref="CDD:133469" Site order(43,118,120,122,126..128,162,171,215..217,239..242) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:133469" CDS 1..306 /gene="ADE1" /locus_tag="YAR015W" /coded_by="NM_001178216.1:1..921" /experiment="EXISTENCE:direct assay:GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [PMID:1756975]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006164 purine nucleotide biosynthetic process [PMID:1756975]" /experiment="EXISTENCE:direct assay:GO:0006189 'de novo' IMP biosynthetic process [PMID:1756975]" /experiment="EXISTENCE:mutant phenotype:GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity [PMID:5767024|PMID:5767025]" /experiment="EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:5767024|PMID:5767025]" /experiment="EXISTENCE:mutant phenotype:GO:0006189 'de novo' IMP biosynthetic process [PMID:5767025|PMID:5767024]" /note="N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851272" /db_xref="SGD:S000000070" ORIGIN 1 msitkteldg ilplvargkv rdiyevdagt llfvatdris aydvimensi pekgilltkl 61 sefwfkflsn dvrnhlvdia pgktifdylp aklsepkykt qledrsllvh khkliplevi 121 vrgyitgsaw keyvktgtvh glkqpqglke sqefpepift pstkaeqgeh denispaqaa 181 elvgedlsrr vaelavklys kckdyakekg iiiadtkfef gidektneii lvdevltpds 241 srfwngasyk vgesqdsydk qflrdwltan klngvngvkm pqdivdrtra kyieayetlt 301 gskwsh // LOCUS NP_009410 435 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase KIN3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009410 VERSION NP_009410.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178217.1 REFERENCE 1 (residues 1 to 435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 435) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06995. Method: conceptual translation. FEATURES Location/Qualifiers source 1..435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..435 /product="serine/threonine protein kinase KIN3" /EC_number="2.7.11.1" /calculated_mol_wt="51073" Region 24..343 /region_name="STKc_Nek2" /note="Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2; cd08217" /db_xref="CDD:270857" Site order(31..35,39,52,54,85,103..106,110,112,174,176,178..179, 181,231,234,236,250..253) /site_type="active" /db_xref="CDD:270857" Site order(31..32,34..35,39,52,54,85,104..106,110,179,181,236) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270857" Site order(35,110,112,174,176,178,234,250..253) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270857" Site order(230..242,245..253) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270857" CDS 1..435 /gene="KIN3" /locus_tag="YAR018C" /gene_synonym="FUN52; NPK1" /coded_by="NM_001178217.1:1..1308" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:12386167]" /note="Nonessential serine/threonine protein kinase; possible role in DNA damage response; influences tolerance to high levels of ethanol" /db_xref="GeneID:851273" /db_xref="SGD:S000000071" ORIGIN 1 mhrrqffqey rspqqqqghp prseyqvlee igrgsfgsvr kvihiptkkl lvrkdikygh 61 mnskerqqli aecsilsqlk henivefynw dfdeqkevly lymeycsrgd lsqmikhykq 121 ehkyipekiv wgilaqllta lykchygvel ptlttiydrm kppvkgkniv ihrdlkpgni 181 flsyddsdyn ineqvdghee vnsnyyrdhr vnsgkrgspm dysqvvvklg dfglakslet 241 siqfattyvg tpyymspevl mdqpysplsd iwslgcvife mcslhppfqa knylelqtki 301 kngkcdtvpe yysrglnaii hsmidvnlrt rpstfellqd iqirtarksl qlerferkll 361 dyeneltnie kilekqaiey erelsqlkeq ftqaveerar evisgkkvgk vpesingyyg 421 kkfakpayhw qtryr // LOCUS NP_009411 974 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase CDC15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009411 VERSION NP_009411.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178218.2 REFERENCE 1 (residues 1 to 974) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 974) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 974) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 974) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 974) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 974) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06996. On Apr 26, 2011 this sequence version replaced NP_009411.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..974 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..974 /product="serine/threonine protein kinase CDC15" /EC_number="2.7.11.1" /calculated_mol_wt="110111" Region 24..272 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(31..34,37,39,52,54,83,99..102,146,150..151,153, 163..164) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..974 /gene="CDC15" /locus_tag="YAR019C" /gene_synonym="LYT1; RLT1" /coded_by="NM_001178218.2:1..2925" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:11404483|PMID:23579499]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10662594|PMID:12832486]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12832486]" /experiment="EXISTENCE:genetic interaction:GO:1903024 positive regulation of ascospore-type prospore membrane formation [PMID:32788308]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:11267871]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:23579499]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:11267871]" /experiment="EXISTENCE:mutant phenotype:GO:0051229 meiotic spindle disassembly [PMID:32788308|PMID:17660551]" /experiment="EXISTENCE:mutant phenotype:GO:1903024 positive regulation of ascospore-type prospore membrane formation [PMID:32788308]" /experiment="EXISTENCE:mutant phenotype:GO:1904750 negative regulation of protein localization to nucleolus [PMID:32788308]" /note="Hippo-like kinase of the Mitotic Exit Network; promotes exit by activating the Dbf2p kinase; component of a non-canonical Hippo pathway with Sps1p required for prospore membrane closure, spindle disassembly and sustained release of Cdc14p during meiotic anaphase II; complexes with Sps1p and contributes to its phosphorylation; phosphorylates the RNAPII CTD during mitosis; localizes to the bud neck and SPB during anaphase and telophase; relocalizes to the cytoplasm upon DNA replication stress" /db_xref="GeneID:851274" /db_xref="SGD:S000000072" ORIGIN 1 mnsmadtdrv nltpiqrase ksvqyhlkqv igrgsygvvy kainkhtdqv vaikevvyen 61 deelndimae isllknlnhn nivkyhgfir ksyelyille ycangslrrl isrsstglse 121 nesktyvtqt llglkylhge gvihrdikaa nillsadntv kladfgvsti vnssaltlag 181 tlnwmapeil gnrgastlsd iwslgatvve mltknppyhn ltdaniyyav endtyyppss 241 fseplkdfls kcfvknmykr ptadqllkhv winstenvkv dklnkfkedf tdadyhwdad 301 fqeeklnisp skfslaaapa awaennqeld lmpptesqll sqlkssskpl tdlhvlfsvc 361 sleniadtii eclsrttvdk rlitafgsif vydtqhnhsr lrlkfiamgg ipliikfehl 421 akefvidypq tliecgimyp pnfaslktpk yilelvyrfy dltstafwcr wcfkhldisl 481 llnniherra qsillklssy apwsfekilp slidsklkkk ilispqityv vfksinymit 541 tnddkihksa ipsssslpls ssptrnspvn svqspsrspv hslmatrpss pmrhksisnf 601 phltissksr llielpegff twltsffvdm aqikdlsvlk yftklcyltv hinstflndl 661 ldndaffafi rnidtiipfi ddaktaafiw kqitaicvem sldmdqmsas lfstamnfir 721 kknntsisgl eiilnclhft lrnvnddvap tvgsseshsv flikvnndaa ielpidqlvd 781 lfyalndddv nlsklisift kicslpgfen ltiniifhpn fyekivsffd tyfnslliqi 841 dllkfiklif sksllklydy tgqpdpikqt epnrrnkatv fklrailvqi teflnnnwnk 901 dvpkrnsnqv ggdsvlicql cedirslskk gslqkvssvt aaigssptkd ersnlrsskd 961 ksdgfsvpit tfqt // LOCUS NP_009412 55 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009412 VERSION NP_009412.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178219.1 REFERENCE 1 (residues 1 to 55) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 55) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 55) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 55) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06997. Method: conceptual translation. FEATURES Location/Qualifiers source 1..55 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..55 /product="seripauperin PAU7" /calculated_mol_wt="5543" Region 25..>55 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..55 /gene="PAU7" /locus_tag="YAR020C" /coded_by="NM_001178219.1:1..168" /note="Member of the seripauperin multigene family; active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme" /db_xref="GeneID:851275" /db_xref="SGD:S000000073" ORIGIN 1 mvkltsiaag vaaiaagasa aatttlsqsd ervnlvelgv yvsdirahla eyysf // LOCUS NP_009413 179 aa linear PLN 30-JUN-2025 DEFINITION DUP240 family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009413 VERSION NP_009413.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178220.2 REFERENCE 1 (residues 1 to 179) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 179) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 179) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 179) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06998. On Apr 26, 2011 this sequence version replaced NP_009413.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..179 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..179 /product="DUP240 family protein" /calculated_mol_wt="20572" Region 22..120 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..179 /gene="DFP1" /locus_tag="YAR023C" /coded_by="NM_001178220.2:1..540" /note="Putative integral membrane protein; member of DUP240 gene family" /db_xref="GeneID:851276" /db_xref="SGD:S000000074" ORIGIN 1 minfllfvlt ilatltniwf sgvlspamvi riclggsmvv lqiwsfsrpi snetfrtkll 61 levithrpsi agkewktity nmnqylfkag lwktpyhffc ehqcyeffkd likgkypdvq 121 wdtantqpfi svpenqaatq nsdveptvkw clfkaaeiqa havreywqsq ypdvgipai // LOCUS NP_009414 235 aa linear PLN 30-JUN-2025 DEFINITION DUP240 family protein UIP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009414 VERSION NP_009414.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178221.1 REFERENCE 1 (residues 1 to 235) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 235) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 235) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06999. Method: conceptual translation. FEATURES Location/Qualifiers source 1..235 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..235 /product="DUP240 family protein UIP3" /calculated_mol_wt="26986" Region 93..170 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..235 /gene="UIP3" /locus_tag="YAR027W" /coded_by="NM_001178221.1:1..708" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11056382]" /note="Putative integral membrane hypothetical protein; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family" /db_xref="GeneID:851279" /db_xref="SGD:S000000075" ORIGIN 1 mqtpsentdv kldtldepsa hlieenvalp edtfnsywsy ilneiarckp lmimflipvc 61 lvllitffhd ikgilvflvi slilsiiill igitafvset lnkgfiikll vevitrkpav 121 ggkewriiay nmnqylfdhg iwhtpyyffc ehrchkffks likqtrsnah lssptngaen 181 tqsntpakev snemvkpyif ssdpvleayl ikaaeihkea efeywrkqyp evdlp // LOCUS NP_009415 234 aa linear PLN 30-JUN-2025 DEFINITION DUP240 family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009415 VERSION NP_009415.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178222.1 REFERENCE 1 (residues 1 to 234) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 234) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 234) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 234) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07000. Method: conceptual translation. FEATURES Location/Qualifiers source 1..234 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..234 /product="DUP240 family protein" /calculated_mol_wt="26327" Region 80..165 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..234 /gene="KTD1" /locus_tag="YAR028W" /coded_by="NM_001178222.1:1..705" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:36800387|PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0097237 cellular response to toxic substance [PMID:36800387]" /experiment="EXISTENCE:mutant phenotype:GO:0097237 cellular response to toxic substance [PMID:36800387]" /note="Killer toxin defense factor; key polymorphic factor in the defense against K28 toxin; localizes mainly to vacuolar membrane; most likely acts against K28 during its trafficking after endocytosis; member of DUP240 gene family" /db_xref="GeneID:851280" /db_xref="SGD:S000000076" ORIGIN 1 mqtpsentdv kmdtldepsa hlieenvalp edtfsshlsy vlyeiahckp imfmiiiivs 61 lislivlfhd ndgctvilvm slivasmalm vvaaftfgka iteqefmikl lveviarkpa 121 gkewgtvayn mnqylfmkrl wytpyyfysg kkcheffttl ikevnsgshs dsssnsaedt 181 qspvsagkts nglnnfysir sdpilmayvl katqiekeaq seywrkqypd adlp // LOCUS NP_009416 74 aa linear PLN 30-JUN-2025 DEFINITION DUP240 family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009416 VERSION NP_009416.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178223.1 REFERENCE 1 (residues 1 to 74) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 74) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 74) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 74) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07001. Method: conceptual translation. FEATURES Location/Qualifiers source 1..74 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..74 /product="DUP240 family protein" /calculated_mol_wt="8779" Region <1..38 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..74 /gene="DFP2" /locus_tag="YAR029W" /coded_by="NM_001178223.1:1..225" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:12101299]" /note="Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" /db_xref="GeneID:851281" /db_xref="SGD:S000000077" ORIGIN 1 mnkylfdhki wstpyyfyce edchrlflsf iegrtfekpt snaeenvqet eagesftlnp 61 gedfqncfpr qril // LOCUS NP_009418 298 aa linear PLN 30-JUN-2025 DEFINITION pheromone-regulated DUP240 family protein PRM9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009418 VERSION NP_009418.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178224.1 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 298) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07002. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..298 /product="pheromone-regulated DUP240 family protein PRM9" /calculated_mol_wt="34942" Region 143..232 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..298 /gene="PRM9" /locus_tag="YAR031W" /coded_by="NM_001178224.1:1..897" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12101299]" /experiment="EXISTENCE:physical interaction:GO:0005783 endoplasmic reticulum [PMID:12925749]" /note="Pheromone-regulated protein; contains 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family; PRM9 has a paralog, PRM8, that arose from a segmental duplication" /db_xref="GeneID:851282" /db_xref="SGD:S000000078" ORIGIN 1 mspqyhfyfv sfrnlvlnek clrskkqvmk sfnwyktdry fdphnilqhh sraiektryk 61 lgmqtssest daksdfldep saylieknva lpkdifgsyl sywiyevtrh kaavillvli 121 vtsilllvff yntefcvafe illfsfcfpg tcmvviafse pigdrefkvk llmeiitrkp 181 avkgkewrti tykmnqylfd hglwdtpyyf yrdedchryf lslikgrtfk kqkessasnv 241 kdaqsndeta gtpneaaess sfsagpnfik lltkaaeieq qfqkeywrqe ypgvdeff // LOCUS NP_009419 234 aa linear PLN 30-JUN-2025 DEFINITION DUP240 family protein MST28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009419 VERSION NP_009419.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178225.1 REFERENCE 1 (residues 1 to 234) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 234) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 234) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 234) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07003. Method: conceptual translation. FEATURES Location/Qualifiers source 1..234 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..234 /product="DUP240 family protein MST28" /calculated_mol_wt="26960" Region 75..171 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..234 /gene="MST28" /locus_tag="YAR033W" /coded_by="NM_001178225.1:1..705" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:12925749]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:12925749]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:12925749]" /experiment="EXISTENCE:genetic interaction:GO:0016050 vesicle organization [PMID:12925749]" /experiment="EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:12101299]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12101299]" /experiment="EXISTENCE:physical interaction:GO:0016050 vesicle organization [PMID:12925749]" /note="Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles; MST28 has a paralog, MST27, that arose from a segmental duplication" /db_xref="GeneID:851284" /db_xref="SGD:S000000079" ORIGIN 1 mqtppestdv kldtlnepsa hlieknvalp kdifrsylsy wiyeiarytp vmilslvigv 61 lvlliiffnd neacvfnsai faftslvgll iilsdgnpkl vsrrnfrtel lvdvitrkpa 121 vegkewriit ynmnqylfnh gqwhtpyyfy sdedcyryfl rlvegvtpkk qtatsignsp 181 vtakpedaie saspssrlny qnfllkaaei erqaqenywr rrhpnidall kkte // LOCUS NP_009420 687 aa linear PLN 30-JUN-2025 DEFINITION carnitine O-acetyltransferase YAT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009420 VERSION NP_009420.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178226.1 REFERENCE 1 (residues 1 to 687) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 687) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 687) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 687) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07004. Method: conceptual translation. FEATURES Location/Qualifiers source 1..687 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..687 /product="carnitine O-acetyltransferase YAT1" /EC_number="2.3.1.7" /calculated_mol_wt="77635" Region 7..637 /region_name="Carn_acyltransf" /note="Choline/Carnitine o-acyltransferase; pfam00755" /db_xref="CDD:459926" CDS 1..687 /gene="YAT1" /locus_tag="YAR035W" /coded_by="NM_001178226.1:1..2064" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:18427809|PMID:14576278|PMID:16823961|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0009437 carnitine metabolic process [PMID:11329169]" /note="Outer mitochondrial carnitine acetyltransferase; minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated" /db_xref="GeneID:851285" /db_xref="SGD:S000000080" ORIGIN 1 mpnlkrlpip plqdtlnryl arveplqder qnrrtrrtvl saenldalnt lherlleyda 61 rlaesnpess yieqfwyday llydatvvln vnpyfqlqdd ptikdtpeta aqgpygahtv 121 qvrraarltt silkfirqir hgtlrtdtvr gktplsmdqy erlfgssrip pgpgepschl 181 qtdatshhvv amyrgqfywf dvldtrnepi fatpeqlewn lysiimdaes agsgsapfgv 241 fttesrrvws nirdylfhad dctnwrnlkl idsalfvvcl ddvafaadqq deltrsmlcg 301 tstinldphq hqpplnvqtg tclnrwydkl qlivtkngka ginfehtgvd ghtvlrlatd 361 iytdsilsfa rgvtknvvdi fsdddgkpss sslasaahsa nlitiprkle wrtdnflqss 421 lhfaetrisd lisqyefvnl dfsnygashi ktvfkcspda fvqqvfqvay falygrfetv 481 yepamtkafq ngrteairsv tgqsklfvks lldqdasdat kiqllhdact ahsqitrecs 541 qglgqdrhly alyclwnqwy kdklelppif rdkswttmqn nvlstsncgn pclksfgfgp 601 vtangfgigy iirdhsvsvv vssrhrqtar faslmeksll eidrifkrqq araakpaart 661 tasantksed mkyllsgydy fdvsvsg // LOCUS NP_878042 26 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAR035C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878042 VERSION NP_878042.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184583.1 REFERENCE 1 (residues 1 to 26) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 26) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 26) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 26) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 26) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 26) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07005. Method: conceptual translation. FEATURES Location/Qualifiers source 1..26 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..26 /product="uncharacterized protein" /calculated_mol_wt="3189" CDS 1..26 /locus_tag="YAR035C-A" /coded_by="NM_001184583.1:1..81" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:32034123]" /note="hypothetical protein; emerging ORF that arose de novo from non-genic locus; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; localizes to mitochondria" /db_xref="GeneID:1466430" /db_xref="SGD:S000028595" ORIGIN 1 mrlnysrcyy ssqrrrqslp krfpli // LOCUS NP_009421 1188 aa linear PLN 30-JUN-2025 DEFINITION oxysterol-binding protein related protein SWH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009421 VERSION NP_009421.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178227.1 REFERENCE 1 (residues 1 to 1188) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1188) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1188) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1188) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07006. On Jan 23, 2006 this sequence version replaced NP_009421.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1188 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1188 /product="oxysterol-binding protein related protein SWH1" /calculated_mol_wt="134967" Region 56..117 /region_name="Ank_4" /note="Ankyrin repeats (many copies); pfam13637" /db_xref="CDD:372654" Region 56..94 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(57..58,61..63,65..66,70,73,94,96,98,102..103, 106..108,110..111,115,118,193,195,198,202..203,206..208, 210..211,215,218,227) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region <89..265 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 96..193 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 195..227 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 281..383 /region_name="PH_Osh1p_Osh2p_yeast" /note="Yeast oxysterol binding protein homologs 1 and 2 Pleckstrin homology (PH) domain; cd13292" /db_xref="CDD:241446" Region <562..>774 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 799..1177 /region_name="Oxysterol_BP" /note="Oxysterol-binding protein; pfam01237" /db_xref="CDD:460126" CDS 1..1188 /gene="SWH1" /locus_tag="YAR042W" /gene_synonym="OSH1; YAR044W" /coded_by="NM_001178227.1:1..3567" /experiment="EXISTENCE:direct assay:GO:0000138 Golgi trans cisterna [PMID:11408574]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:12727870]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:11408574]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12727870]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:25420878]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:20008566]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]" /experiment="EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:16585271]" /experiment="EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]" /note="Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats and FFAT motif; interacts with ER anchor Scs2p at the nucleus-vacuole junction; regulated by sterol binding; SWH1 has a paralog, OSH2, that arose from the whole genome duplication" /db_xref="GeneID:851286" /db_xref="SGD:S000000081" ORIGIN 1 meqpdlssva iskpllklkl ldalrqgsfp nlqdllkkqf qplddpnvqq vlhlmlhyav 61 qvapmavike ivhhwvsttn ttflnihldl nerdsngntp lhiaayqsrg divaflldqp 121 tindcvlnns hlqaiemckn lniaqmmqvk rstyvaetaq efrtafnnrd fghlesilss 181 prnaelldin gmdpetgdtv lhefvkkrdv imcrwllehg adpfkrdrkg klpielvrkv 241 nendtatntk iaidielkkl leratreqsv idvtnnnlhe aptykgylkk wtnfaqgykl 301 rwfilssdgk lsyyidqadt knacrgslnm sscslhldss eklkfeiigg nngvirwhlk 361 gnhpietnrw vwaiqgairy akdreillhn gpyspslals hglsskvsnk enlhatskrl 421 tksphlskst ltqndhdndd dstnnnnnks nndyddnnnn nnnddddydd ddesrpliep 481 lplissrsqs lseitpgphs rkstvsstra adipsddegy seddsdddgn ssytmengge 541 ndgdedlnai ygpyiqklhm lqrsisiela slnellqdkq qhdeywntvn tsietvseff 601 dklnrltsqr ekrmiaqmtk qrdvnnvwiq svkdlemelv dkdeklvald kerknlkkml 661 qkklnnqpqv eteaneesdd ansmikgsqe stntleeivk fieatkesde dsdadeffda 721 eeaasdkkan dsedlttnke tpanakpqee apedeslivi sspqvekknq llkegsfvgy 781 edpvrtklal dednrpkigl wsvlksmvgq dltkltlpvs fneptsllqr vsedieyshi 841 ldqaatfeds slrmlyvaaf tasmyasttn rvskpfnpll getfeyartd gqyrffteqv 901 shhppisatw tespkwdfyg ecnvdssfng rtfavqhlgl wyitirpdhn isvpeetysw 961 kkpnntvigi lmgkpqvdns gdvkvtnhtt gdycmlhyka hgwtsagaye vrgevfnkdd 1021 kklwvlgghw ndsiygkkvt arggeltldr iktansatgg pkldgskfli wkanerpsvp 1081 fnltsfaltl nalpphlipy laptdsrlrp dqramengey dkaaaekhrv evkqraakke 1141 reqkgeeyrp kwfvqeehpv tkslywkfng eywnkrknhd fkdcadif // LOCUS NP_009424 1537 aa linear PLN 30-JUN-2025 DEFINITION flocculin FLO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009424 VERSION NP_009424.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178230.1 REFERENCE 1 (residues 1 to 1537) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1537) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1537) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 1537) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1537) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 1537) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07007. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1537 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..1537 /product="flocculin FLO1" /calculated_mol_wt="160538" Region 100..249 /region_name="PA14" /note="PA14 domain; pfam07691" /db_xref="CDD:400161" Region <229..1102 /region_name="FhaB" /note="Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]; COG3210" /db_xref="CDD:442443" Region 1235..1276 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" Region 1304..>1502 /region_name="Chi1" /note="Chitinase [Carbohydrate transport and metabolism]; COG3469" /db_xref="CDD:442692" Region 1349..1392 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" CDS 1..1537 /gene="FLO1" /locus_tag="YAR050W" /gene_synonym="FLO2; FLO4" /coded_by="NM_001178230.1:1..4614" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11956747|PMID:9483793]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000128 flocculation [PMID:19420680|PMID:23383507|PMID:11027318|PMID:7483845|PM ID:19013280]" /experiment="EXISTENCE:mutant phenotype:GO:0005537 D-mannose binding [PMID:9851992]" /note="Lectin-like protein involved in flocculation; cell wall protein that binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; important for co-flocculation with other yeasts, mediating interaction with specific species; FLO1 has a paralog, FLO5, that arose from a segmental duplication" /db_xref="GeneID:851289" /db_xref="SGD:S000000084" ORIGIN 1 mtmphrymfl avftllalts vasgateacl pagqrksgmn infyqyslkd sstysnaaym 61 aygyasktkl gsvggqtdis idynipcvss sgtfpcpqed sygnwgckgm gacsnsqgia 121 ywstdlfgfy ttptnvtlem tgyflppqtg sytfkfatvd dsailsvgga tafnccaqqq 181 ppitstnfti dgikpwggsl ppniegtvym yagyyypmkv vysnavswgt lpisvtlpdg 241 ttvsddfegy vysfdddlsq snctvpdpsn yavstttttt epwtgtftst stemttvtgt 301 ngvptdetvi virtpttast iitttepwns tftststelt tvtgtngvrt detiivirtp 361 ttattaittt epwnstftst stelttvtgt nglptdetii virtpttatt amtttqpwnd 421 tftststelt tvtgtnglpt detiivirtp ttattamttt qpwndtftst stelttvtgt 481 nglptdetii virtpttatt amtttqpwnd tftststeit tvtgtnglpt detiivirtp 541 ttattamttp qpwndtftst stemttvtgt nglptdetii virtpttatt aitttepwns 601 tftststemt tvtgtnglpt detiivirtp ttattaittt qpwndtftst stemttvtgt 661 nglptdetii virtpttatt amtttqpwnd tftststeit tvtgttglpt detiivirtp 721 ttattamttt qpwndtftst stemttvtgt ngvptdetvi virtptsegl istttepwtg 781 tftststemt tvtgtngqpt detvivirtp tseglvtttt epwtgtftst stemttitgt 841 ngvptdetvi virtptsegl istttepwtg tftststemt titgtngqpt detvivirtp 901 tseglisttt epwtgtftst stemthvtgt ngvptdetvi virtptsegl istttepwtg 961 tftststevt titgtngqpt detvivirtp tseglisttt epwtgtftst stemttvtgt 1021 ngqptdetvi virtptsegl vttttepwtg tftststems tvtgtnglpt detvivvktp 1081 ttaissslss sssgqitssi tssrpiitpf ypsngtsvis ssvisssvts slftsspvis 1141 ssvisssttt stsifsessk ssviptssst sgssesetss agsvssssfi ssesskspty 1201 sssslplvts attsqetass lppatttkts eqttlvtvts ceshvctesi spaivstatv 1261 tvsgvtteyt twcpisttet tkqtkgtteq ttettkqttv vtisscesdv csktaspaiv 1321 ststatingv tteyttwcpi sttesrqqtt lvtvtscesg vcsetaspai vstatatvnd 1381 vvtvyptwrp qtaneesvss kmnsatgett tntlaaettt ntvaaetitn tgaaetktvv 1441 tsslsrsnha etqtasatdv ighsssvvsv setgntkslt ssglstmsqq prstpassmv 1501 gystasleis tyagsansll agsglsvfia slllaii // LOCUS NP_009429 99 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAR064W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009429 VERSION NP_009429.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178235.1 REFERENCE 1 (residues 1 to 99) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 99) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 99) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 99) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07008. Method: conceptual translation. FEATURES Location/Qualifiers source 1..99 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..99 /product="uncharacterized protein" /calculated_mol_wt="11008" CDS 1..99 /locus_tag="YAR064W" /coded_by="NM_001178235.1:1..300" /note="Pseudogenic fragment with similarity to flocculins; YAR064W has a paralog, YHR213W-B, that arose from a segmental duplication" /db_xref="GeneID:851294" /db_xref="SGD:S000000089" ORIGIN 1 mlidfccsyi agthgrerap sftgtfvshv sgenncrprr seitqpcasg tekkhfaate 61 kpctnslegs rkdflslplg hsylflfcfw rmicsepkl // LOCUS NP_009430 203 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAR066W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009430 VERSION NP_009430.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180045.1 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 203) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07009. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..203 /product="uncharacterized protein" /calculated_mol_wt="20462" CDS 1..203 /locus_tag="YAR066W" /coded_by="NM_001180045.1:1..612" /note="Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YAR066W has a paralog, YHR214W, that arose from a segmental duplication" /db_xref="GeneID:851295" /db_xref="SGD:S000002144" ORIGIN 1 mfnrfnkfqa avalallsrg algdsytnst ssadlssits vssasasata sdslsssdgt 61 vylpsttisg dltvtgkvia teavevaagg kltlldgeky vfssdlkvhg dlvvekseas 121 yegtafdvsg etfevsgnfs aeetgavsas iysftpssfk ssgdislsls kakkgevtfs 181 pysnagtfsl snailnggsv sgl // LOCUS NP_009431 161 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YAR068W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009431 VERSION NP_009431.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178236.1 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 161) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07010. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..161 /product="uncharacterized protein" /calculated_mol_wt="17880" CDS 1..161 /locus_tag="YAR068W" /coded_by="NM_001178236.1:1..486" /note="Fungal-specific hypothetical protein; induced in respiratory-deficient cells; YAR068W has a paralog, YHR214W-A, that arose from a segmental duplication" /db_xref="GeneID:851296" /db_xref="SGD:S000000091" ORIGIN 1 mpqvqswfpv qkqptlavtf tplpqlshah lplppshlvt ktdamfqhql lptqlqpfpp 61 shtplllllt vttmavtprl sllnvlkklq qppflqnhtl llplltvttt avtprlslpr 121 lpnkhhwpla qspslllqll illlpapslv lsfnpkvwll v // LOCUS NP_009434 467 aa linear PLN 30-JUN-2025 DEFINITION acid phosphatase PHO11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009434 VERSION NP_009434.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178239.1 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 467) AUTHORS Bussey,H., Kaback,D.B., Zhong,W., Vo,D.T., Clark,M.W., Fortin,N., Hall,J., Ouellette,B.F., Keng,T., Barton,A.B. et al. TITLE The nucleotide sequence of chromosome I from Saccharomyces cerevisiae JOURNAL Proc. Natl. Acad. Sci. U.S.A. 92 (9), 3809-3813 (1995) PUBMED 7731988 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-5-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07011. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="I" Protein 1..467 /product="acid phosphatase PHO11" /EC_number="3.1.3.2" /calculated_mol_wt="52627" Region 65..399 /region_name="His_Phos_2" /note="Histidine phosphatase superfamily (branch 2); pfam00328" /db_xref="CDD:395259" Site order(74..75,78,175,337..338) /site_type="active" /note="catalytic core [active]" /db_xref="CDD:132717" CDS 1..467 /gene="PHO11" /locus_tag="YAR071W" /coded_by="NM_001178239.1:1..1404" /experiment="EXISTENCE:direct assay:GO:0003993 acid phosphatase activity [PMID:8817921]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:8817921]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication" /db_xref="GeneID:851299" /db_xref="SGD:S000000094" ORIGIN 1 mlksavysil aaslvnagti plgklsdidk igtqteifpf lggsgpyysf pgdygisrdl 61 pescemkqvq mvgrhgeryp tvskaksimt twyklsnytg qfsgalsfln ddyeffirdt 121 knlemettla nsvnvlnpyt gemnakrhar dflaqygymv enqtsfavft snsnrchdta 181 qyfidglgdk fnislqtise aesagantls ahhscpawdd dvnddilkky dtkylsgiak 241 rlnkenkgln ltssdantff awcayeinar gysdicnift kdelvrfsyg qdletyyqtg 301 pgydvvrsvg anlfnasvkl lkesevqdqk vwlsfthdtd ilnylttigi iddknnltae 361 hvpfmentfh rswyvpqgar vytekfqcsn dtyvryvind avvpietcst gpgfsceind 421 fydyaekrva gtdflkvcnv ssvsnstelt ffwdwntkhy ndtllkq // LOCUS NP_009437 792 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL113C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009437 VERSION NP_009437.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180054.1 REFERENCE 1 (residues 1 to 792) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 792) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 792) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 792) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 792) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 792) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 792) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07012. Method: conceptual translation. FEATURES Location/Qualifiers source 1..792 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..792 /product="uncharacterized protein" /calculated_mol_wt="86846" CDS 1..792 /locus_tag="YBL113C" /coded_by="NM_001180054.1:1..2379" /note="Helicase-like protein encoded within the telomeric Y' element" /db_xref="GeneID:852159" /db_xref="SGD:S000002153" ORIGIN 1 mdlnqrkekk gqhvgccgsr tdlsadtvel iermdrlaen qatasmsiva lpssfqesns 61 sdrcrkycss dedsdtcihg sanastnatt nsstnattta sinvrtsatt tasinvrtsa 121 tttestnsnt natttestns stnatttasi nvrtsattte stnsstnatt tasinvrtsa 181 tttestnsst natttasinv rtsatttest nsntnastna ttnsstnatt tastnvrtsa 241 ttnattnsst natttastnv rtsatttast nvrtsattta sinvrtsatt tesinsstna 301 tttestnsnt satttestds ntnatttasi nvrtsattte stnsntsatt testdsntsa 361 tttastnsst natttastns stnatttest nasakedank dgnaednrfh pvtdinkesy 421 krkgsqmvfl erkklkaqfp ntsenmnvlq flgfrsdeik hlflygidiy fcpegvftqy 481 glckgcqkmf glcvcwagqk vsyrriawea lavermlrnd eeykeyledi epyhgdpvgy 541 lkyfsvkrre iysqiqrnya wylaitrrre tisvldstrg kqgsqvfrms grqikelyyk 601 vwsnlreskt evlqyflnwd ekkcreewea kddtvfveal ekvgvfqrlr smtsaglqgp 661 qyvklqfsrh hrqlrsryel slgmhlrdql algvtpskvp hwtaflsmli glfynktfrq 721 kleylleqis emwllphwld lanvevlaad ntrvplymlm vavhkeldsd dvpdgrfdii 781 llcrdssrev ge // LOCUS NP_009438 105 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL112C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009438 VERSION NP_009438.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180053.1 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 105) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07013. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..105 /product="uncharacterized protein" /calculated_mol_wt="11843" Region <2..44 /region_name="HELICc" /note="helicase superfamily c-terminal domain; smart00490" /db_xref="CDD:197757" CDS 1..105 /locus_tag="YBL112C" /coded_by="NM_001180053.1:1..318" /note="hypothetical protein; YBL112C is contained within TEL02L" /db_xref="GeneID:852160" /db_xref="SGD:S000002152" ORIGIN 1 mqvligtklv tegidikqlm mvimldnrln iieliqgvgr lrdgglcyll srknswaarn 61 rkgelppike gciteqvref ygleskkgkk gpacwmlwlq drpvc // LOCUS NP_009439 667 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL111C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009439 VERSION NP_009439.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180052.1 REFERENCE 1 (residues 1 to 667) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 667) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 667) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 667) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07014. Method: conceptual translation. FEATURES Location/Qualifiers source 1..667 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..667 /product="uncharacterized protein" /calculated_mol_wt="76116" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 368..540 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" CDS 1..667 /locus_tag="YBL111C" /coded_by="NM_001180052.1:1..2004" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22842922]" /note="Helicase-like protein encoded within the telomeric Y' element; relocalizes from mitochondrion to cytoplasm upon DNA replication stress" /db_xref="GeneID:852161" /db_xref="SGD:S000002151" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekivvsvmv gknvqkfltf vedepdfqgg pipskylipk kinlmvytlf 121 qvhtlkfnrk dydtlslfyl nrgyynelsf rvlercyeia sarpndsstm rtftdfvsgt 181 pivrslqkst irkygynlap ymflllhvde lsifsayqas lpgekkvdte rlkrdlcprk 241 pteikyfsqi cndmmnkkdr lgdvlataqr irrrynkngs seprlktldg ltserwiqwl 301 glesdyhcsf sstrnaedvv ageaassdhd qkisrvtrkr prepkstndi lvagrklfgs 361 sfefrdlhql rlcheiymad tpsvavqapp gygktelfhl plialaskgd vkyvsflfvp 421 ytvllancmi rlgrrgclnv apvrnfieeg cdgvtdlyvg iyddlastnf tdriaaweni 481 vectfrtnnv klgylivdef hnfetevyrq sqfggitnld fdafekaifl sgtapeavad 541 aalqrigltg lakksmdine lkrsedlsrg lssyptrmfn likeksevpl ghvhkiwkkv 601 esqpeealkl llalfeiepe skaivvastt neveelacsw rkyfrvvwih gklgccrkgv 661 shkgvch // LOCUS NP_076873 42 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_076873 VERSION NP_076873.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184458.1 REFERENCE 1 (residues 1 to 42) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 42) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 42) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 42) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 42) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 42) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 42) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07015. Method: conceptual translation. FEATURES Location/Qualifiers source 1..42 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..42 /product="seripauperin PAU9" /calculated_mol_wt="4393" Region <1..37 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..42 /gene="PAU9" /locus_tag="YBL108C-A" /coded_by="NM_001184458.1:1..129" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /db_xref="GeneID:852163" /db_xref="SGD:S000007592" ORIGIN 1 mltgiapdqv trmitgvpwy ssrlkpaiss alskdgiyti an // LOCUS NP_009443 196 aa linear PLN 30-JUN-2025 DEFINITION Mix23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009443 VERSION NP_009443.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178347.1 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 196) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07016. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..196 /product="Mix23p" /calculated_mol_wt="22835" Region 38..180 /region_name="MIX23" /note="Intermembrane space protein MIX23; pfam09774" /db_xref="CDD:430815" CDS 1..196 /gene="MIX23" /locus_tag="YBL107C" /gene_synonym="MIC23" /coded_by="NM_001178347.1:1..591" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /note="Mitochondrial intermembrane space hypothetical protein; imported via the MIA import machinery; contains an unusual twin cysteine motif (CX13C CX14C)" /db_xref="GeneID:852167" /db_xref="SGD:S000000203" ORIGIN 1 mvdnrrtfta pqslletnlt fpndepsltt itvtrercvd pslidsflrf lrhgsddiir 61 qklnnyrkgs ingknkckef lkqelypnwq irnniisfce keaaemknet dqqcgnnkkt 121 taeplidari dpyaarerae kqeaqykdwt kvtewvannr kieqiltstt egilrqnceq 181 nndylkeftq fckdns // LOCUS NP_009444 1010 aa linear PLN 30-JUN-2025 DEFINITION putative Rab GTPase-binding protein SRO77 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009444 VERSION NP_009444.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178346.2 REFERENCE 1 (residues 1 to 1010) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1010) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1010) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1010) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1010) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1010) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1010) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07017. On Apr 26, 2011 this sequence version replaced NP_009444.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1010 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1010 /product="putative Rab GTPase-binding protein SRO77" /calculated_mol_wt="111493" Region <48..>151 /region_name="WD40_like" /note="WD40-like domain; pfam17005" /db_xref="CDD:407205" Region 88..122 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 127..167 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 180..233 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 240..264 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 514..916 /region_name="Lgl_C" /note="Lethal giant larvae(Lgl) like, C-terminal; pfam08596" /db_xref="CDD:400768" CDS 1..1010 /gene="SRO77" /locus_tag="YBL106C" /gene_synonym="SNI2; SOP2" /coded_by="NM_001178346.2:1..3033" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:10402465]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:10402465]" /experiment="EXISTENCE:physical interaction:GO:0005886 plasma membrane [PMID:10402465]" /experiment="EXISTENCE:physical interaction:GO:0006893 Golgi to plasma membrane transport [PMID:10402465]" /note="Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; interacts with SNARE protein Sec9p; homolog of Drosophila lethal giant larvae tumor suppressor; SRO77 has a paralog, SRO7, that arose from the whole genome duplication" /db_xref="GeneID:852168" /db_xref="SGD:S000000202" ORIGIN 1 mfkksrhlkn vsnaiksarv hdvsnginsk ffdtkkicty gingritvtt fdytqsllav 61 attageihvy gqkqievvft lknrpqikhm rfikgiylia vdeksniivl svhskqiltt 121 vfcpnsitci etdpsldwml iglesgsili ydvdrnqmsk lkienfqksv flpkerlspv 181 isiqwnprdi gtilisyehi tviysfidyk vkqhffyqle pyapggdlst niekkrtpkv 241 iqslyhpnsl hiltvhedns lvfwdvnsgk liharsifet hvnfpnpalk dcsftetpai 301 fkvswlcqrn peytslliat katenpclpq eitmidlggt pmysvtsfda mskyyakpvq 361 qklfsligka plinflplpk aspyfggchd tnlilllled geletliypa gsfsskasif 421 prslawvrpt vttciaqsvq knlwlgmmti aqsesflkgg ipatrnirrh etrsalltgh 481 sngsvriwda shsevtdnav fevntakvln ratnlaikni sfasetlela vssevgdvil 541 fkfetnkfyg qlpksdalql kfsrfsldds ktilvdvsdr gptnvkqgfi pstvihakkg 601 avsaimnsni gfvavgfieg tliildrrgp aiifnenirv iskagssyvs tvhfcvmeyg 661 ddgfssilml cgtdigelmt fkilpatngr fevkftdatk tnnqgkilgi nsfakdtgys 721 csatiskmqg lskgiaipgf vtisgandir lvspgkskdt halfkypiat sglsfipiid 781 gkgerklsti mivllingdi kvltvpelke vknlrcpvpl saqyvenssi lengdivirt 841 gkfqaslisv lnesatgtnh tadisqhtpi dtlynpdlki gyrpqvnslq wargtiyctp 901 yqldellggi erpeskyees aiargcisss ssnaarklpp gtedhryarp vrssgrsngy 961 gvlksvsrai etrldtvett indyattmgq tmndameetg rdmmksavgf // LOCUS NP_009445 1151 aa linear PLN 30-JUN-2025 DEFINITION protein kinase C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009445 VERSION NP_009445.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178345.2 REFERENCE 1 (residues 1 to 1151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1151) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07018. On Apr 26, 2011 this sequence version replaced NP_009445.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1151 /product="protein kinase C" /EC_number="2.7.11.13" /calculated_mol_wt="131346" Region 1..72 /region_name="HR1_PKC-like_1_fungi" /note="First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins; cd11621" /db_xref="CDD:212011" Site order(8,11,14..15,18..19,21..22,25..26,28..29,51..52,55, 58..59,62) /site_type="other" /note="putative Rho binding site 1 [polypeptide binding]" /db_xref="CDD:212011" Site order(16..17,19..20,23..24,26..27,30..31,46..47,49) /site_type="other" /note="putative Rho binding site 2 [polypeptide binding]" /db_xref="CDD:212011" Region 110..181 /region_name="HR1_PKC-like_2_fungi" /note="Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of fungal Protein Kinase C-like proteins; cd11620" /db_xref="CDD:212010" Site order(121,124,127..128,131..132,134..135,138..139,141..142, 160..161,164,167..168,171) /site_type="other" /note="putative Rho binding site 1 [polypeptide binding]" /db_xref="CDD:212010" Site order(129..130,132..133,136..137,139..140,143..144, 155..156,158) /site_type="other" /note="putative Rho binding site 2 [polypeptide binding]" /db_xref="CDD:212010" Region 211..319 /region_name="C2_fungal_Pkc1p" /note="C2 domain found in protein kinase C (Pkc1p) in Saccharomyces cerevisiae; cd08689" /db_xref="CDD:176071" Region 413..464 /region_name="C1_ScPKC1-like_rpt1" /note="first protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; cd20822" /db_xref="CDD:410372" Region 478..536 /region_name="C1_ScPKC1-like_rpt2" /note="second protein kinase C conserved region 1 (C1 domain) found in Saccharomyces cerevisiae protein kinase C-like 1 (ScPKC1) and similar proteins; cd20823" /db_xref="CDD:410373" Region 828..1145 /region_name="STKc_PKC" /note="Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; cd05570" /db_xref="CDD:270722" Site order(830..834,838,851,853,888,904..905,907,911,913,949, 951,953..954,956,966..967,970,984..989,1016,1022,1025) /site_type="active" /db_xref="CDD:270722" Site order(830..834,838,851,853,888,905..907,911,949,951, 953..954,956,966..967) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270722" Site order(834,911,913,949,951,953,970,984..989,1016,1022,1025) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270722" Site order(966..978,980..989) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270722" Site 1125 /site_type="other" /note="turn motif phosphorylation site [posttranslational modification]" /db_xref="CDD:270722" Site 1139..1144 /site_type="other" /note="hydrophobic motif (HM)" /db_xref="CDD:270722" CDS 1..1151 /gene="PKC1" /locus_tag="YBL105C" /gene_synonym="CLY15; CLY5; CLY7; HPO2; RSF8; STT1" /coded_by="NM_001178345.2:1..3456" /experiment="EXISTENCE:direct assay:GO:0004697 diacylglycerol-dependent serine/threonine kinase activity [PMID:8207005|PMID:26179915]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11545731]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11545731]" /experiment="EXISTENCE:direct assay:GO:0005856 cytoskeleton [PMID:15910746]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009267 cellular response to starvation [PMID:32184286]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:32184286]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:10893184]" /experiment="EXISTENCE:direct assay:GO:0032165 prospore septin filament array [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0034063 stress granule assembly [PMID:32184286]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20385774]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:7874200]" /experiment="EXISTENCE:mutant phenotype:GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly [PMID:21163942]" /experiment="EXISTENCE:mutant phenotype:GO:0032186 cellular bud neck septin ring organization [PMID:26179915]" /experiment="EXISTENCE:mutant phenotype:GO:0035556 intracellular signal transduction [PMID:7874200]" /experiment="EXISTENCE:mutant phenotype:GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening [PMID:21163942]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:7874200]" /note="Protein serine/threonine kinase; essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)" /db_xref="GeneID:852169" /db_xref="SGD:S000000201" ORIGIN 1 msfsqleqni kkkiaveeni irgasalkkk tsnvmviqkc ntnirearqn leyledslkk 61 lrlktaqqsq gengsedner cnskeygfls tkspnehifs rldlvkydcp slaqriqyml 121 qqlefklqve kqyqeantkl tklyqidgdq rsssaaegga meskyriqml nkalkkyqai 181 nvdfdqfkhq pndimdnqqp kfrrkqltgv ltigitaard vdhiqspmfa rkpesyvtik 241 iddtikartk psrndrwsed fqipvekgne ieitvydkvn dslipvaimw lllsdiaeei 301 rkkkagqtne qqgwvnasni nggsslasee gstltstysn saiqstsakn vqgentstsq 361 istnswfvle psgqilltlg fhkssqierk qlmgglhrhg aiinrkeeif eqhghhfvqk 421 sfynimccay cgdflrytgf qcqdckflch kkcytnvvtk ciaktstdtd pdeaklnhri 481 phrflptsnr gtkwcchcgy ilpwgrhkvr kcsecgimch aqcahlvpdf cgmsmemank 541 ilktiqdtkr nqekkkrtvp saqlgssigt angsdlspsk laeranaplp pqprkhdktp 601 spqkvgrdsp tkqhdpiidk rislqthgre klnkfidene aylnftegaq qtaefsspek 661 tldptsnrrs lgltdlsieh sqtweskddl mrdelelwka qreemeleik qdsgeiqedl 721 evdhidletk qkldwenknd freadltids thtnpfrdmn setfqieqdh askevlqetv 781 slaptsthas rttdqqspqk sqtstsakhk kraakrrkvs ldnfvllkvl gkgnfgkvil 841 skskntdrlc aikvlkkdni iqnhdiesar aekkvfllat ktkhpfltnl ycsfqtenri 901 yfamefiggg dlmwhvqnqr lsvrrakfya aevllalkyf hdngviyrdl klenilltpe 961 ghikiadygl ckdemwygnr tstfcgtpef mapeilkeqe ytkavdwwaf gvllyqmllc 1021 qspfsgdded evfnailtde plypidmage ivqifqgllt kdpekrlgag prdadevmee 1081 pffrninfdd ilnlrvkppy ipeikspedt syfeqeftsa pptltplpsv lttsqqeefr 1141 gfsfmpddld l // LOCUS NP_009446 1038 aa linear PLN 30-JUN-2025 DEFINITION Sea4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009446 VERSION NP_009446.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178344.1 REFERENCE 1 (residues 1 to 1038) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1038) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1038) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1038) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1038) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1038) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1038) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07019. On Feb 2, 2004 this sequence version replaced NP_009446.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1038 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1038 /product="Sea4p" /calculated_mol_wt="117505" Region <943..1036 /region_name="zf-RING_16" /note="RING/Ubox like zinc-binding domain; cl24077" /db_xref="CDD:390276" CDS 1..1038 /gene="SEA4" /locus_tag="YBL104C" /gene_synonym="YBL103C-A" /coded_by="NM_001178344.1:1..3117" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]" /experiment="EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:23716719]" /note="Subunit of SEACAT, a subcomplex of the SEA complex; Sea4p, along with Rtc1p and Mtc5p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; contains an N-terminal beta-propeller fold and a C-terminal RING motif" /db_xref="GeneID:852170" /db_xref="SGD:S000000200" ORIGIN 1 mglikkvthw sydnlidyls vnptrdevth ykvdpenesd esiiklhtvk dfgsitcldy 61 seseigmigv gekngylrif nisgqnsssp ashapvglna nnetsmtnas ggkaaqaeni 121 vgsvsnlkdt qgypvsetny dirvrakkqr cinslgintn gliamgldrn khdsslqiwd 181 mnyhddshet inpmfsyctn esivslkfln dtsvlaastk flkeidvrsp npiyqhptrl 241 tydiklnpfn dwqfstygdd gtlaiwdrrk lsdqaslgdl nvasplltfe klvgsgaasr 301 kymnscfrws cvrnnefatl hrgdtikrwr lgyycdsnrd iaadddnemn ienlfvssvh 361 dtntmydrva tfdyiprsnn gtslicmrqs gtiyrmpise vcskailnnr nslllsnfen 421 teideirvnn eheksnlenv ktilknlsfe dldvsedyfp sghdepnnei eyselseeen 481 egsndvldsk rgfelfwkpe kllekdisvi mrtraslgyg ldpmntvemi dssknlqnna 541 yirntwrwia iakasvddgt mvsgdldlgy egvigiwngi ngisnqdryr qetilsdkql 601 nkemekiikl rrknrdrnsp ianaagspky vqrrlcliis gwdlsrsdye dkyniimkng 661 hyekaaawav ffgdipkave ilgsakkerl rliataiagy laykdlpgnn awrqqcrkms 721 selddpylrv ifafiadndw wdilyepais lrerlgvalr flndtdlttf ldrtsstvie 781 ngeleglilt gitpngidll qsyvnktsdv qsaalisifg spryfrdqrv dewiqtyrdm 841 lkswelfsmr arfdvlrskl srtktgvlta dikprqiyiq cqnckqnint prtsspssav 901 stsagnykng eayrrnnady kkfntgssea qaadekprhk yccphcgssf prcaiclmpl 961 gtsnlpfvin gtqsrdpmqt edsqdganre lvsrklklne wfsfclscnh gmhaghaeew 1021 fdrhnvcptp gctcqcnk // LOCUS NP_009447 486 aa linear PLN 30-JUN-2025 DEFINITION Rtg3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009447 VERSION NP_009447.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178343.1 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 486) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07020. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..486 /product="Rtg3p" /calculated_mol_wt="54009" Region 289..349 /region_name="bHLHzip_USF_MITF" /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; cd11387" /db_xref="CDD:381393" Site order(289,291,294..298,302,328..331) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:381393" Site order(301,304,307,311,334,338,341..342,344..345,349) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:381393" CDS 1..486 /gene="RTG3" /locus_tag="YBL103C" /coded_by="NM_001178343.1:1..1461" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9032238]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10848632]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10848632]" /experiment="EXISTENCE:direct assay:GO:0031930 mitochondria-nucleus signaling pathway [PMID:9032238]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9032238|PMID:9242640]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19840933]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9032238]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9242640|PMID:12393187|PMID:9032238]" /experiment="EXISTENCE:mutant phenotype:GO:0071400 cellular response to oleic acid [PMID:12069115|PMID:12393187]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:9867831]" /note="bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways; forms a complex with another bHLH/Zip protein, Rtg1p, to activate the pathways; target of Hog1p" /db_xref="GeneID:852171" /db_xref="SGD:S000000199" ORIGIN 1 mmnnneseae nqrlldelmn qtkvlqetld fslvtptphh nddykihgsa ypggetpaqq 61 heklsyinth nsndnnnlmg sqarsnsqtp tastiyeeae sqssylddmf rtsqggrpvt 121 qnsissigqg plrssysmay dspvdramnt plqqqeglka elphdflfqh gtddtmynlt 181 ddlssslsss insdmmtpnt ysssfsynpq slgpasvsst yspkvrspss sfragsflss 241 sfrhgsintp rtrhtsissn mtenigpgsv pkilggltsd eklrrkrefh naverrrrel 301 ikqkikelgq lvppsllnyd dlgkqikpnk giildrtvey lqylaeilei qarkkkalla 361 kikeleekks svaalspftn nhhassgqnn senseeriid irsvpnalmn eqnskaelhn 421 wepplydsvg nhnhagtmes hphtniheel keflsgdlie aednaklmfg ddnsnpadyl 481 lefgsg // LOCUS NP_009448 215 aa linear PLN 30-JUN-2025 DEFINITION Sft2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009448 VERSION NP_009448.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178342.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 215) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07021. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..215 /product="Sft2p" /calculated_mol_wt="24143" Region 7..214 /region_name="SFT2" /note="Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion]; COG5102" /db_xref="CDD:227433" CDS 1..215 /gene="SFT2" /locus_tag="YBL102W" /coded_by="NM_001178342.1:1..648" /experiment="EXISTENCE:direct assay:GO:0000138 Golgi trans cisterna [PMID:7596416]" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:10406798|PMID:9725919]" /experiment="EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:10406798]" /note="Tetra-spanning membrane protein found mostly in the late Golgi; non-essential; can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5" /db_xref="GeneID:852172" /db_xref="SGD:S000000198" ORIGIN 1 mseeppsdqv nslrdslnrw nqtrqqnsqg fnesaktlfs swadslntra qdiyqtlpvs 61 rqdlvqdqep swfqlsrter mvlfvcfllg atacftlctf lfpvlaakpr kfgllwtmgs 121 llfvlafgvl mgplaylkhl tarerlpfsm fffatcfmti yfaafskntv ltitcallel 181 vaviyyaisy fpfgatglrm lssagvnsar gvlri // LOCUS NP_009449 1117 aa linear PLN 30-JUN-2025 DEFINITION Ecm21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009449 VERSION NP_009449.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178341.1 REFERENCE 1 (residues 1 to 1117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1117) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07022. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1117 /product="Ecm21p" /calculated_mol_wt="123479" Region 585..>648 /region_name="Arrestin_C" /note="Arrestin (or S-antigen), C-terminal domain; smart01017" /db_xref="CDD:214976" Region <781..878 /region_name="Arrestin_C" /note="Arrestin (or S-antigen), C-terminal domain; smart01017" /db_xref="CDD:214976" CDS 1..1117 /gene="ECM21" /locus_tag="YBL101C" /gene_synonym="ART2" /coded_by="NM_001178341.1:1..3354" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:32744498]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:18976803|PMID:31658248]" /experiment="EXISTENCE:mutant phenotype:GO:0070086 ubiquitin-dependent endocytosis [PMID:32744498|PMID:31658248|PMID:18976803]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:31658248]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]" /experiment="EXISTENCE:physical interaction:GO:0070086 ubiquitin-dependent endocytosis [PMID:18976803]" /note="Alpha-arrestin, ubiquitin ligase adaptor for Rsp5p; regulates starvation- and substrate-induced Ub-dependent endocytosis of select plasma membrane localized amino acid transporters; substrate of Rsp5p-mediated Lys63-polyubiquitination and Ubp2-mediated deubiquitination; promoter contains several Gcn4p binding sites required for induction in response to starvation via Gcn4p and the general amino acid control pathway; ECM21 has a paralog, CSR2, that arose from the whole genome duplication" /db_xref="GeneID:852173" /db_xref="SGD:S000000197" ORIGIN 1 mpfitsrpva knsshslset dlnqskgqpf qpsptkklgs mqqrrrssti rhalssllgg 61 anvhspavln nttkggnnng nirssntdaq llgkkqnkqp ppnarrhstt aiqgsisdsa 121 tttprsstsd tnrrtsgrls vdqeprisgg rysqieedst vldfdddhns savvssdlss 181 tsltrlansk kfneqfliey ltargllgpk tvlsneylki sistsgesvf lptissndde 241 ylsrlnglnd gtddaeadff mdgidqqegn tpslattaaa tesggsinen rdtllrenns 301 gdhpgsgsel ntrsveidss mvsysiaviv svkkptrftd mqlelcsrvk vfwntgvppt 361 ktfneefyna asmkwnlnde nfdlfvplsi spddqmienn sndrqmrlfk nipteerlyl 421 dktktkasll naidvnkthl yqpgdyvflv pvvfsnhipe tiylpsarvs yrlrlatkai 481 nrkgfyrqds nspqpivspd sssslsstts slkltetesa qahrrisntl fskvknhlhm 541 sshqlknees geedifaeyp ikvirtpppv avstankpiy inrvwtdsls yeisfaqkyv 601 slnsevpiki klapicknvc vkrihvsite rvtfvskgye yeydqtdpva kdpynpyyld 661 faskrrkers vslfeirtke kgtralreei vensfndnll syspfdddsd skgnpkerlg 721 itepiiietk lkfpkyedld krtakiippy gidaytsipn pehavangps hrrpsvigfl 781 sghkgskshe enekpvydpk fhqtiiksns glpvkthtrl ntpkrglyld slhfsnvycr 841 hkleimlris kpdpecpskl rhyevlidtp iflvseqcns gnmelptydm atmegkgnqv 901 plsmnsdffg ntcpppptfe eaisvpaspi vspmgspnim asydpdllsi qqlnlsrtts 961 vsgpsgysdd agvpnvnrns isnanamngs isnsafvsgn sgqgvarara tsvndrsrfn 1021 nldkllstps pvnrshnssp tnglsqangt vripnatten skdkqneffk kgytlanvkd 1081 deeqegivss ssadsllshg nepprydeiv plmsdee // LOCUS NP_878043 39 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL100W-C [Saccharomyces cerevisiae S288C]. ACCESSION NP_878043 VERSION NP_878043.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184585.1 REFERENCE 1 (residues 1 to 39) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 39) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 39) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 39) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07023. Method: conceptual translation. FEATURES Location/Qualifiers source 1..39 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..39 /product="uncharacterized protein" /calculated_mol_wt="4511" CDS 1..39 /locus_tag="YBL100W-C" /gene_synonym="YBL101W-C" /coded_by="NM_001184585.1:1..120" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466439" /db_xref="SGD:S000028598" ORIGIN 1 msrsifffss lflsplnkir niggkvenpw ksqirdwkn // LOCUS NP_009451 438 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009451 VERSION NP_009451.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180049.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 438) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07025. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..438 /product="gag protein" /calculated_mol_wt="49767" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..438 /locus_tag="YBL100W-A" /gene_synonym="YBL101W-A" /coded_by="NM_001180049.1:1..1317" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:852174" /db_xref="SGD:S000002148" ORIGIN 1 mesqqlhqnp hslhgsayas vtskevssnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqdq hsevpqaktk vrnnvlppht ltseenfytw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lrpateri // LOCUS NP_009450 1770 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009450 VERSION NP_009450.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180050.2 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1770) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07024. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1770 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="202085" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 574..641 /region_name="gag_pre-integrs" /note="GAG-pre-integrase domain; pfam13976" /db_xref="CDD:372857" Region 660..761 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1285..>1468 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1621..1757 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1625..1628,1662..1664,1667,1700,1727,1754) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1770 /locus_tag="YBL100W-B" /gene_synonym="YBL101W-B" /coded_by="join(NM_001180050.2:1..1293, NM_001180050.2:1295..5314)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:852175" /db_xref="SGD:S000002149" ORIGIN 1 mesqqlhqnp hslhgsayas vtskevssnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqdq hsevpqaktk vrnnvlppht ltseenfytw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lgqqqkeskp thtidsndel pdhllidsga sqtlvrsahy lhhatpnsei 481 nivdaqkqdi pinaignlhf nfqngtktsi kalhtpniay dllslselan qnitacftrn 541 tlersdgtvl apivkhgdfy wlskkylips hiskltinnv nksksvnkyp yplihrmlgh 601 anfrsiqksl kknavtylke sdiewsnast yqcpdcligk stkhrhvkgs rlkyqesyep 661 fqylhtdifg pvhhlpksap syfisftdek trfqwvyplh drreesilnv ftsilafikn 721 qfnarvlviq mdrgseytnk tlhkfftnrg itacytttad srahgvaerl nrtllndcrt 781 llhcsglpnh lwfsavefst iirnslvspk ndksarqhag lagldittil pfgqpvivnn 841 hnpdskihpr gipgyalhps rnsygyiiyl pslkktvdtt nyvilqdnqs kldqfnydtl 901 tfdddlnrlt ahnqsfieqn eteqsydqnt esdhdyqsei einsdplvnd fssqsmnplq 961 ldhepvqkvr alkevdadis eynilpspvr srtphiinke stemggties dttsprhsst 1021 ftarnqkrpg spndmidlts qdrvnyelen ikttrlggte epyiqrnsdt nikyrttnst 1081 psiddrspds dsttpiisie tkaacdntps idtdppeyrs sdhatpnimp dkssknvtad 1141 silddlplpd ltnksptdts dvskdiphih srqtnsslgg mddsnvlttt kskkrsledn 1201 eteievsrdt wnnknmrsle pprskkrinl iaaikgvksi kpvrttlryd eaitynednk 1261 ekdryieayh keinqllrmn twdtnkyydr ndidpkkvin smfifnkkrd gthkarfvar 1321 gdiqhpdtyd sdmqsntvhh yalmtslsia ldndyyitql dissaylyad ikeelyirpp 1381 phlglndkll rlrkslyglk qsganwyeti ksylinccdm qevrgwscvf knsqvticlf 1441 vddmilfskd lnanekiitt lkkqydtkii nlgesdneiq ydilgleiky qrskymklgm 1501 ekslteklpk lnvplnpkgk klsapgqpgh yidqdeleid edeykekvhe mqkliglasy 1561 vgykfrfdll yyintlaqhi lfpsrqvldm tyeliqfmwd trdkqliwhk nkptkpdnkl 1621 vaisdasygn qpyyksqign ifllngkvig gkstkasltc tstteaeiha vseaipllnn 1681 lshlvqelnk kpiikglltd srstisiiks tneekfrnrf fgtkamrlrd evsgnnlyvy 1741 yietkkniad vmtkplpikt fklltnkwih // LOCUS NP_009453 545 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_009453 VERSION NP_009453.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178339.2 REFERENCE 1 (residues 1 to 545) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 545) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 545) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 545) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07026. On Apr 26, 2011 this sequence version replaced NP_009453.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..545 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..545 /product="F1F0 ATP synthase subunit alpha" /calculated_mol_wt="58477" Region 42..545 /region_name="PRK09281" /note="F0F1 ATP synthase subunit alpha; Validated" /db_xref="CDD:236448" CDS 1..545 /gene="ATP1" /locus_tag="YBL099W" /coded_by="NM_001178339.2:1..1638" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10869431]" /experiment="EXISTENCE:direct assay:GO:0045259 proton-transporting ATP synthase complex [PMID:15294286|PMID:17082766]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:2876995]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:2876995]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:1827117|PMID:2876995]" /note="Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated; N-terminally propionylated in vivo" /db_xref="GeneID:852177" /db_xref="SGD:S000000195" ORIGIN 1 mlartaairs lsrtlinstk aarpaaaala strrlastka qptevssile erikgvsdea 61 nlnetgrvla vgdgiarvfg lnniqaeelv efssgvkgma lnlepgqvgi vlfgsdrlvk 121 egelvkrtgn ivdvpvgpgl lgrvvdalgn pidgkgpida agrsraqvka pgilprrsvh 181 epvqtglkav dalvpigrgq reliigdrqt gktavaldti lnqkrwnngs deskklycvy 241 vavgqkrstv aqlvqtleqh damkysiiva ataseaaplq ylapftaasi gewfrdngkh 301 alivyddlsk qavayrqlsl llrrppgrea ypgdvfylhs rlleraakls ekegsgslta 361 lpvietqggd vsayiptnvi sitdgqifle aelfykgirp ainvglsvsr vgsaaqvkal 421 kqvagslklf laqyrevaaf aqfgsdldas tkqtlvrger ltqllkqnqy splateeqvp 481 liyagvnghl dgielsrige fessflsylk snhnelltei rekgelskel laslksates 541 fvatf // LOCUS NP_009454 460 aa linear PLN 30-JUN-2025 DEFINITION kynurenine 3-monooxygenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009454 VERSION NP_009454.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178338.1 REFERENCE 1 (residues 1 to 460) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 460) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 460) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 460) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07027. Method: conceptual translation. FEATURES Location/Qualifiers source 1..460 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..460 /product="kynurenine 3-monooxygenase" /EC_number="1.14.13.9" /calculated_mol_wt="52299" Region 1..398 /region_name="UbiH" /note="2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; COG0654" /db_xref="CDD:440419" CDS 1..460 /gene="BNA4" /locus_tag="YBL098W" /coded_by="NM_001178338.1:1..1383" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:genetic interaction:GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan [PMID:12062417]" /experiment="EXISTENCE:mutant phenotype:GO:0004502 kynurenine 3-monooxygenase activity [PMID:15806102]" /note="Kynurenine 3-monooxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; localizes to mitochondria and peroxisomes; putative therapeutic target for Huntington disease" /db_xref="GeneID:852179" /db_xref="SGD:S000000194" ORIGIN 1 msesvaiiga glvgclaala fskegynvtl ydfrqdprld ttknknlksi nlaisargid 61 alksidpdac ehilqdmipm kgrmihdlkg rqesqlyglh geainsinrs vlnnslldel 121 eksttelkfg hklvkiewtd dkqichfaig edlktphtek ydfvigcdga ysatrsqmqr 181 kvemdfsqey mnlryielyi ppteefkpny ggnfaiapdh lhiwprhkfm lialansdgs 241 ftstffgskd qisdlitsks rvreflienf pdiinimdld davkrfityp keslvcvnck 301 pydvpggkai llgdaahamv pfygqgmncg fedvrilmal lkkhsgdrsr afteytqtrh 361 kdlvsitela krnykemshd vtskrfllrk kldalfsiim kdkwiplytm isfrsdisys 421 raleragkqt rilkfleslt lgmlsiggyk lfkfltrers // LOCUS NP_009455 754 aa linear PLN 30-JUN-2025 DEFINITION condensin subunit BRN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009455 VERSION NP_009455.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178337.2 REFERENCE 1 (residues 1 to 754) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 754) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 754) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 754) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07028. On Apr 26, 2011 this sequence version replaced NP_009455.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..754 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..754 /product="condensin subunit BRN1" /calculated_mol_wt="86086" Region 27..754 /region_name="LOC7" /note="Chromosome condensation complex Condensin, subunit H [Chromatin structure and dynamics / Cell division and chromosome partitioning]; COG5229" /db_xref="CDD:227554" CDS 1..754 /gene="BRN1" /locus_tag="YBL097W" /coded_by="NM_001178337.2:1..2265" /experiment="EXISTENCE:direct assay:GO:0000796 condensin complex [PMID:10811823]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10749931]" /experiment="EXISTENCE:genetic interaction:GO:0003682 chromatin binding [PMID:11864994]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:10749931]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:7698648|PMID:10811823|PMID:10749931]" /experiment="EXISTENCE:mutant phenotype:GO:0070058 tRNA gene clustering [PMID:18708579]" /note="Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission" /db_xref="GeneID:852180" /db_xref="SGD:S000000193" ORIGIN 1 mttqlryenn ddderveynl ftnrstmman feewikmatd nkinsrnswn falidyfydl 61 dvlkdgenni nfqkasatld gcikiyssrv dsvttetgkl lsglaqrktn gasngddsng 121 gngeglggds deanieidpl tgmpisndpd vnntrrrvyn rvlettlvef etikmkeldq 181 eliidplfkk alvdfdegga kslllntlni dntarvifda sikdtqnvgq gklqrkeeel 241 ierdslvdde nepsqslist rndstvndsv isapsmedei lslgmdfikf dqiavceisg 301 sieqlrnvve dinqakdfie nvnnrfdnfl teeelqaavp dnaeddsdgf dmgmqqelcy 361 pdenhdntsh deqdddnvns ttgsifekdl mayfdenlnr nwrgrehwkv rnfkkanlvn 421 kesdlleetr ttigdttdkn ttddksmdtk kkhkqkkvle idffktddsf edkvfaskgr 481 tkidmpiknr kndthyllpd dfhfstdrit rlfikpgqkm slfshrkhtr gdvssglfek 541 stvsanhsnn diptiadehf wadnyerkeq eekekeqske vgdvvggald npfeddmdgv 601 dfnqafegtd dneeasvkld lqddedhkfp irenkvtysr vskkvdvrrl kknvwrsinn 661 liqehdsrkn reqssndset htedestkel kfsdiiqgis kmysddtlkd istsfcficl 721 lhlanehglq ithtenyndl ivnyedlatt qaas // LOCUS NP_009457 270 aa linear PLN 30-JUN-2025 DEFINITION Mrx3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009457 VERSION NP_009457.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178335.1 REFERENCE 1 (residues 1 to 270) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 270) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 270) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 270) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07029. Method: conceptual translation. FEATURES Location/Qualifiers source 1..270 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..270 /product="Mrx3p" /calculated_mol_wt="30414" Region 121..216 /region_name="hot_dog" /note="The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; cl00509" /db_xref="CDD:469797" Site order(150..151,184..187) /site_type="active" /note="active site 2 [active]" /db_xref="CDD:239524" Site order(156,159..160,163,176..178) /site_type="active" /note="active site 1 [active]" /db_xref="CDD:239524" CDS 1..270 /gene="MRX3" /locus_tag="YBL095W" /coded_by="NM_001178335.1:1..813" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:25546499]" /note="Protein that associates with mitochondrial ribosome; likely functions in cristae junction formation; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:852181" /db_xref="SGD:S000000191" ORIGIN 1 msrtipflfk lvnravilpt agftlgvgaf vkawpddagv lslndpqtpa elisatksrq 61 pmelqrvdil aqieksevyn klaqdekmhh vlfsekipsg hreyhvgqgl lfgkgkleid 121 plvfhdvnhg eltviyhlga elgnrdgnvh kgllslllde alcycgfpll pskrgvtarl 181 sleffedipv dttiilkanv keikgrkcii eghleqfple vssrngtrsw nlphiwgfnh 241 kqemakkfak ancilveptw fkyfkwldmf // LOCUS NP_009459 220 aa linear PLN 30-JUN-2025 DEFINITION Rox3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009459 VERSION NP_009459.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178333.1 REFERENCE 1 (residues 1 to 220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 220) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07030. Method: conceptual translation. FEATURES Location/Qualifiers source 1..220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..220 /product="Rox3p" /calculated_mol_wt="24726" Region 26..219 /region_name="Rox3" /note="Rox3 mediator complex subunit; pfam08633" /db_xref="CDD:430118" CDS 1..220 /gene="ROX3" /locus_tag="YBL093C" /gene_synonym="MED19; NUT3; RMR1; SSN7; SSX2" /coded_by="NM_001178333.1:1..663" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1656237]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]" /experiment="EXISTENCE:mutant phenotype:GO:0001113 transcription open complex formation at RNA polymerase II promoter [PMID:20048049]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15831453]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16452140]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:15964818]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme" /db_xref="GeneID:852184" /db_xref="SGD:S000000189" ORIGIN 1 masrvdettv psyyyyvdpe ttytyqqpnp lqdlisvygl ddisrqvart nldgtkavkl 61 rksyknqiad lsgkfstipt rengkggqia hilfqnnpdm miqppqqgqn mseqqwreql 121 rnrdialfqp pnfdwdlcss vlsqfersyp sefanqnqgg aqapfdiddl afdldgtgks 181 qsgsnsgnns kkrknkssgs smatpthsds hedmkrrrle // LOCUS NP_009460 130 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL32 RPL32 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009460 VERSION NP_009460.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178332.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 130) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07031. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..130 /product="60S ribosomal protein eL32 RPL32" /calculated_mol_wt="14640" Region 14..121 /region_name="Ribosomal_L32e" /note="Ribosomal protein L32; pfam01655" /db_xref="CDD:460283" CDS 1..130 /gene="RPL32" /locus_tag="YBL092W" /coded_by="NM_001178332.1:1..393" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L32; overexpression disrupts telomeric silencing; homologous to mammalian ribosomal protein L32, no bacterial homolog" /db_xref="GeneID:852185" /db_xref="SGD:S000000188" ORIGIN 1 maslphpkiv kkhtkkfkrh hsdryhrvae nwrkqkgids vvrrrfrgni sqpkigygsn 61 kktkflspsg hktflvanvk dletltmhtk tyaaeiahni saknrvvila rakalgikvt 121 npkgrlalea // LOCUS NP_009461 175 aa linear PLN 30-JUN-2025 DEFINITION phospholipid metabolism-regulating protein SCS22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009461 VERSION NP_009461.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184321.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 175) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07032. On Feb 2, 2004 this sequence version replaced NP_009461.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..175 /product="phospholipid metabolism-regulating protein SCS22" /calculated_mol_wt="19547" Region 1..107 /region_name="Motile_Sperm" /note="MSP (Major sperm protein) domain; pfam00635" /db_xref="CDD:459882" CDS 1..175 /gene="SCS22" /locus_tag="YBL091C-A" /coded_by="NM_001184321.1:1..528" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0008654 phospholipid biosynthetic process [PMID:15668246]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]" /note="Cytosolic protein involved in the regulation of phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER and plasma membrane (PM); regulates PI4P levels by controlling access of Sac1p to PM substrate PI4P; VAMP-associated protein (VAP) homolog; role in NVJ integrity and micronucleophagy; SCS22 has a paralog, SCS2, that arose from the whole genome duplication" /db_xref="GeneID:852186" /db_xref="SGD:S000007228" ORIGIN 1 mrivpeklvf kaplnkqste yiklendgek rvifkvrtsa ptkycvrpnv aiigahesvn 61 vqivflglpk staddemdqk rdkflivtlp ipaayqnved gellsdwpnl eeqykddivf 121 kkikifhsvl pkrkpsgnhd aesarapsag ngqslssral liitviallv gwiyy // LOCUS NP_009462 421 aa linear PLN 30-JUN-2025 DEFINITION methionine aminopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009462 VERSION NP_009462.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178331.2 REFERENCE 1 (residues 1 to 421) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 421) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 421) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 421) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07033. On Apr 26, 2011 this sequence version replaced NP_009462.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..421 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..421 /product="methionine aminopeptidase" /EC_number="3.4.11.18" /calculated_mol_wt="47387" Region <58..421 /region_name="PTZ00053" /note="methionine aminopeptidase 2; Provisional" /db_xref="CDD:240246" CDS 1..421 /gene="MAP2" /locus_tag="YBL091C" /coded_by="NM_001178331.2:1..1266" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0070006 metalloaminopeptidase activity [PMID:8618900]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:11811952]" /note="Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p" /db_xref="GeneID:852187" /db_xref="SGD:S000000187" ORIGIN 1 mtdaeiensp asdlkelnle negveqqdqa kadesdpves kkkknkkkkk kksnvkkiel 61 lfpdgkypeg awmdyhqdfn lqrttdeesr ylkrdlerae hwndvrkgae ihrrvrraik 121 drivpgmklm diadmientt rkytgaenll amedpksqgi gfptglslnh caahftpnag 181 dktvlkyedv mkvdygvqvn gniidsaftv sfdpqydnll aavkdatytg ikeagidvrl 241 tdigeaiqev mesyeveing etyqvkpcrn lcghsiapyr ihggksvpiv kngdttkmee 301 gehfaietfg stgrgyvtag gevshyarsa edhqvmptld saknllktid rnfgtlpfcr 361 ryldrlgqek ylfalnnlvr hglvqdyppl ndipgsytaq fehtillhah kkevvskgdd 421 y // LOCUS NP_009463 177 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein bS21m MRP21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009463 VERSION NP_009463.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178330.1 REFERENCE 1 (residues 1 to 177) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 177) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 177) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 177) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07034. Method: conceptual translation. FEATURES Location/Qualifiers source 1..177 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..177 /product="mitochondrial 37S ribosomal protein bS21m MRP21" /calculated_mol_wt="20264" Region 105..154 /region_name="Ribosomal_S21" /note="Ribosomal protein S21; pfam01165" /db_xref="CDD:460092" CDS 1..177 /gene="MRP21" /locus_tag="YBL090W" /gene_synonym="bS21m; MRP50" /coded_by="NM_001178330.1:1..534" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9528754]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:9528754]" /experiment="EXISTENCE:genetic interaction:GO:0070124 mitochondrial translational initiation [PMID:9528754]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:9528754]" /note="Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences" /db_xref="GeneID:852188" /db_xref="SGD:S000000186" ORIGIN 1 mlkstlrlsr islrrgftti dclrqqnsdi dkiilnpikl aqgsnsdrgq tsksktdnad 61 ilsmeipvdm mqsagrinkr ellseaeiar ssvenaqmrf nsgksiivnk nnpaesfkrl 121 nrimfennip gdkrsqrfym kpgkvaelkr sqrhrkefmm gfkrlieivk dakrkgy // LOCUS NP_009464 459 aa linear PLN 30-JUN-2025 DEFINITION amino acid transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_009464 VERSION NP_009464.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178329.1 REFERENCE 1 (residues 1 to 459) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 459) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 459) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 459) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07035. On Oct 2, 2003 this sequence version replaced NP_009464.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..459 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..459 /product="amino acid transporter" /calculated_mol_wt="50761" Region 1..445 /region_name="Aa_trans" /note="Transmembrane amino acid transporter protein; pfam01490" /db_xref="CDD:279788" CDS 1..459 /gene="AVT5" /locus_tag="YBL089W" /coded_by="NM_001178329.1:1..1380" /note="Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; AVT5 has a paralog, AVT6, that arose from the whole genome duplication" /db_xref="GeneID:852189" /db_xref="SGD:S000000185" ORIGIN 1 mpsnvrsgvl tllhtacgag vlampfafkp fglmpglitl tfcgicslcg lllqtriaky 61 vpksenasfa kltqlinpsi svvfdfaiav kcfgvgvsyl iivgdlvpqi vqsifyrndd 121 nmsgsqehhm fldrrlyitl iivfvisplc fkrslnslry asmiaivsva ylsgliiyhf 181 vnrhqlergq vyfmvphgds qshsplttlp ifvfaytchh nmfsvineqv dksfkvirri 241 pifaivlayf lyiiiggtgy mtfgenivgn iltlypnsis ttigrlamll lvmlafplqc 301 hpcrssvkni iifienfrkg klydnrasfi pldnfnsedp qeaptqqnne epnlrseslr 361 hiniitlcil lfsyllaisi tslakvlaiv gatgstsisf ilpglfgykl igseftgtne 421 rvptsikifk ylslslfiwg iavmvaslsa ivflgtssh // LOCUS NP_009465 2787 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding protein kinase TEL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009465 VERSION NP_009465.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178328.2 REFERENCE 1 (residues 1 to 2787) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2787) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2787) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 2787) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07036. On Apr 26, 2011 this sequence version replaced NP_009465.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2787 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..2787 /product="DNA-binding protein kinase TEL1" /EC_number="2.7.11.1" /calculated_mol_wt="321395" Region 6..157 /region_name="TAN" /note="Telomere-length maintenance and DNA damage repair; pfam11640" /db_xref="CDD:463317" Region 292..2787 /region_name="TEL1" /note="Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032" /db_xref="CDD:227365" CDS 1..2787 /gene="TEL1" /locus_tag="YBL088C" /coded_by="NM_001178328.2:1..8364" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:11095737]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24150937]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:17656141]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:37303233]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:8604297]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:25628362]" /experiment="EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:17347674]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:3513174|PMID:8604297]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:25329891]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:17347674]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:17347674]" /experiment="EXISTENCE:mutant phenotype:GO:0042770 signal transduction in response to DNA damage [PMID:17693258]" /note="Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; binds to phosphatidylinositol-4-phosphate; acts with Red1p and Mec1p to promote interhomolog recombination by phosphorylation of Hop1; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene" /db_xref="GeneID:852190" /db_xref="SGD:S000000184" ORIGIN 1 medhgivetl nflsstkike rnnaldeltt ilkedperip tkalsttaea lvellaseht 61 kycdllrnlt vsttnklsls enrlstisyv lrlfveksce rfkvktlkll lavvpelmvk 121 dgskslldav svhlsfalda liksdpfklk fmihqwislv dkiceyfqsq mklsmvdktl 181 tnfisillnl laldtvgifq vtrtitwtvi dflrlskken gntrlimsli nqlilkchcf 241 svidtlmlik eawsynltig ctsnelvqdq lslfdvmsse lmnhklpymi gqenyveelr 301 seslvslyre yillrlsnyk pqlftvnhve fsyirgsrdk nswfalpdfr lrdrggrsvw 361 lkilgitksl ltyfalnrkn enysllfkrr kcdsdipsil risddmdtfl ihlleenssh 421 efevlglqlc sfygtlqdft ksfaeqlkel lfskfekiqc fnwvcfsfip llsqkecels 481 ngdmarlfkv clplvksnes cqlsclllan sikfskqlls dektinqiyd lyelsdilgp 541 ilvtnesfml wgylqyvgkd fqsmngissa drifewlksk wnqlrgtdak qdqfcnfisw 601 lgnkydpenp fndkkgegan pvslcwdesh kiwqhfqeqr efllgvkpee ksecfntpff 661 nlpkvsldlt ryneilyrll eniesdafss plqkftwvak liqivdnlcg dstfsefiaa 721 ykrttlitip qlsfdsqnsy qsffeevlsi rtinvdhlvl dkinmkeivn dfirmqknks 781 qtgtsainyf eassedttqn nspytiggrf qkplhstidk avraylwssr nksiserlva 841 ilefsdcvst dvfisylgtv cqwlkqaige kssynkilee ftevlgekll cnhysssnqa 901 mllltsyiea irpqwlsype qplnsdcndi ldwiisrfed nsftgvaptv nlsmlllsll 961 qnhdlshgsi rggkqrvfat fikclqklds sniinimnsi ssymaqvsyk nqsiifyeik 1021 slfgppqqsi eksafyslam smlslvsyps lvfsledmmt ysgfnhtraf iqqalnkitv 1081 afryqnltel feyckfdlim ywfnrtkvpt sklekewdis lfgfadihef lgryfveisa 1141 iyfsqgfnqk wildmlhait gngdaylvdn syylciplaf isggvnelif dilpqisgkt 1201 tvkyhkkyrl lmlkwiirft dlgsltelrs tveklfptsy lspylfenss vsmryqyplh 1261 iplalgatlv qtqfaheknn thefkllfls vitdlektst yigklrcare lkylfvlyen 1321 vlvksstlnf iiirlskfli dtqihdevit ifssllnlad kntfeiepsl pnlfckifiy 1381 lrenkqlsps fqqaiklleh rdlikiktwk ycldaifgni vqddiyente lldasdcgvd 1441 dvvlvsllfs yarrpvaski gcslskaaai nilkhhvpke ylsknfklwf aalsrrilqq 1501 evqrerstnf nnevhlknfe mvfrhpeqph miyqristfn keaelydste vffisecilt 1561 ylvgysigns esefcfrdni mnenkdkvap ldkdvlnaiy plannfgmes ficdtylsvn 1621 epyncwlskf arslihqisf nippivclyp lckgstafce lvltdlffls ttydpkscln 1681 wsnriftqia mllhvkdsei klkmlfnvik mirmgsrcke rnclriyssl dlqeicqisl 1741 kikefkfgyl lfeemnmpni remnintlqk iyecindgdf laglpvphsi egvlnsinri 1801 dsdtwkrflf nnadfdanyt tsleeekesl ikatedsgfy gltsllesrl sgssdvykwn 1861 lelgdwkllt pkvvdskakg lyyaiknlpq dvgfaeksle kslltifdsr qhfisqtewm 1921 dtlnaiiefi kiaaipqdvt sfpqtlmsim kadkerlnti dfydhkttlk srhtlmnvls 1981 rnsldenvkc skylrlgsii qlanyvqlai angapqdalr natlmsktvk niaklyddps 2041 vvsqieklas ftsanalwes reykapvmim rdllaqnekn isesilyddf kllinvpmdq 2101 ikarlvkwss esrlepaaai yekiivnwdi nvedhescsd vfytlgsfld eqaqklrsng 2161 eiedrehrsy tgkstlkale liykntklpe nerkdakrhy nrvllqynrd sevlkalllq 2221 kekflwhalh fylntlvfsn rydndiidkf cglwfenddn skinqllyke igtipswkfl 2281 pwvnqiaski smeenefqkp lqltmkrlly klpydslysv msillyekqs nkdtnisqki 2341 qavkkillel qgydrgafak kyllpvqefc emsvelanlk fvqntktlrl anlkigqywl 2401 kqlnmeklpl ptsnftvkss adgrkarpyi vsvnetvgit ttglslpkiv tfnisdgttq 2461 kalmkgsndd lrqdaimeqv fqqvnkvlqn dkvlrnldlg irtykvvplg pkagiiefva 2521 nstslhqils klhtndkitf dqarkgmkav qtksneerlk aylkitneik pqlrnfffds 2581 fpdpldwfea kktytkgvaa ssivgyilgl gdrhlnnill dcstgepihi dlgiafdqgk 2641 llpipelvpf rltrdivdgf gvtgvdglfr rscervyavl rkdyvkvmcv lnilkwdply 2701 swvmspvkky ehlfeeehei tnfdnvskfi snndrnenqe syralkgvee klmgnglsve 2761 ssvqdliqqa tdpsnlsviy mgwspfy // LOCUS NP_009466 137 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL14 RPL23A [Saccharomyces cerevisiae S288C]. ACCESSION NP_009466 VERSION NP_009466.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178327.1 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 137) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07037. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..137 /product="60S ribosomal protein uL14 RPL23A" /calculated_mol_wt="14342" Region 5..137 /region_name="PTZ00054" /note="60S ribosomal protein L23; Provisional" /db_xref="CDD:185418" CDS 1..137 /gene="RPL23A" /locus_tag="YBL087C" /coded_by="NM_001178327.1:1..414" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L23A; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23A has a paralog, RPL23B, that arose from the whole genome duplication" /db_xref="GeneID:852191" /db_xref="SGD:S000000183" ORIGIN 1 msgngaqgtk frislglpvg aimncadnsg arnlyiiavk gsgsrlnrlp aaslgdmvma 61 tvkkgkpelr kkvmpaivvr qakswrrrdg vflyfednag vianpkgemk gsaitgpvgk 121 ecadlwprva snsgvvv // LOCUS NP_009467 466 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL086C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009467 VERSION NP_009467.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178326.1 REFERENCE 1 (residues 1 to 466) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 466) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 466) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 466) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07038. Method: conceptual translation. FEATURES Location/Qualifiers source 1..466 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..466 /product="uncharacterized protein" /calculated_mol_wt="51866" Region 8..206 /region_name="NT-C2" /note="N-terminal C2 in EEIG1 and EHBP1 proteins; pfam10358" /db_xref="CDD:463058" CDS 1..466 /locus_tag="YBL086C" /coded_by="NM_001178326.1:1..1401" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery" /db_xref="GeneID:852192" /db_xref="SGD:S000000182" ORIGIN 1 mpfnhnskak rpkflldlqi kelvnipqss gycytkwrlk dgtgtsghkv aldgehqtts 61 tqsrgttkhv hvqhhraqwn ysldkpilvk lhldkngrfl kkilvldvff efadansslt 121 sssspngkvk kttyanatal tatgnnsysq kitgklllgt vdiditeyvk edetpttnrf 181 llkhskvnsi invslqlklv rgsyedfnis ksftngqlan yrpgintild ntselsspts 241 ttnqmspknt fsnfngigtt vakpgtnatg nstsikspts tnhkssemtt kpglsttiss 301 smspliesly qktfklpwdp rpgeftprec vedilqggng waknekginl idlqalrlne 361 meeeyynpny gnnlgnkass wppnpsddgy stmgkreyle kkqnwshmsr aqraklrthn 421 dednentand kgsdkdnnsv ednnptdflt drirenknws iitpsg // LOCUS NP_009468 980 aa linear PLN 30-JUN-2025 DEFINITION Boi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009468 VERSION NP_009468.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178325.1 REFERENCE 1 (residues 1 to 980) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 980) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 980) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 980) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 980) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 980) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 980) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07039. Method: conceptual translation. FEATURES Location/Qualifiers source 1..980 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..980 /product="Boi1p" /calculated_mol_wt="109165" Region 17..71 /region_name="SH3_BOI" /note="Src Homology 3 domain of fungal BOI-like proteins; cd11886" /db_xref="CDD:212819" Site order(22,24,27,31,52..53,68,70..71) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212819" Region 226..290 /region_name="SAM_superfamily" /note="SAM (Sterile alpha motif); cl15755" /db_xref="CDD:472832" Region 778..894 /region_name="PH_Boi" /note="Boi family Pleckstrin homology domain; cd13316" /db_xref="CDD:270126" CDS 1..980 /gene="BOI1" /locus_tag="YBL085W" /gene_synonym="BOB1; GIN7" /coded_by="NM_001178325.1:1..2943" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:28751498|PMID:12097146]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12097146]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:12097146]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:12097146]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0000920 septum digestion after cytokinesis [PMID:16615892]" /experiment="EXISTENCE:genetic interaction:GO:0007015 actin filament organization [PMID:31964708]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:17417630]" /experiment="EXISTENCE:mutant phenotype:GO:0099500 vesicle fusion to plasma membrane [PMID:28751498]" /note="Protein involved in polar growth, functionally redundant with Boi2p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication" /db_xref="GeneID:852193" /db_xref="SGD:S000000181" ORIGIN 1 mslegntlgk gaksfplyia vnqyskrmed elnmkpgdki kvitddgeyn dgwyygrnlr 61 tkeeglypav ftkriaiekp enlhksptqe sgnsgvkygn lndsasnigk vsshqqenry 121 tslkstmsdi dkaleelrsg sveqevsksp trvpevstpq lqdeqtliqe ktrneentth 181 dslfsstadl nlsseslkni sksnistksl epssesvrql dlkmakswsp eevtdyfslv 241 gfdqstcnkf kehqvsgkil lelelehlke leinsfgirf qifkeirnik saidsssnkl 301 dadystfafe nqaaqlmpaa tvnrdeiqqq isskcnklss essdrksssv ttelqrpssv 361 vvnpnfklhd paeqildmte vpnlfadkdi fespgrapkp psypspvqpp qspsfnnryt 421 nnnarfppqt typpknknpt vysnglipns stssdnstgk fkfpamnghd snsrkttlts 481 atipsintvn tdeslpaisn issnatshhp nrnsvvynnh krtesgssfv dlfnrismls 541 pvkssfdeee tkqpskasra vfdsarrkss yghsrdasls emkkhrrnss ilsffssksq 601 snptsptkqt ftidpakmts hsrsqsnsys harsqsyshs rkhslvtspl ktslspinsk 661 snialahset ptssnnkeav sqpsegkhkh khkhkskhkh knssskdgss eekskkklfs 721 stkesfvgsk efkrspselt qkstksilpr snakkqqtsa ftegirsita kesmqtadcs 781 gwmskkgtga mgtwkqrfft lhgtrlsyft ntndekergl iditahrvlp asdddrlisl 841 yaaslgkgky cfklvppqpg skkgltftep rvhyfavenk semkawlsai ikatididts 901 vpvissyatp tiplskaqtl leearlqtql rdaeeeegrd qfgwddtqnk rnsnypieqd 961 qfetsdyles safeypggrl // LOCUS NP_009469 758 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit CDC27 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009469 VERSION NP_009469.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178324.2 REFERENCE 1 (residues 1 to 758) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 758) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 758) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 758) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07040. On Apr 26, 2011 this sequence version replaced NP_009469.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..758 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..758 /product="anaphase promoting complex subunit CDC27" /calculated_mol_wt="85265" Region 39..126 /region_name="ANAPC3" /note="Anaphase-promoting complex, cyclosome, subunit 3; pfam12895" /db_xref="CDD:463743" Region 433..635 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" Region 434..466 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 472..500 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 537..736 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" Region 540..568 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(541,544..545,548..549,551,575,578..579,582..583, 585..586,609,612..613,616..617,620) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 573..603 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 608..634 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 642..668 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 676..704 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 710..737 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..758 /gene="CDC27" /locus_tag="YBL084C" /gene_synonym="APC3; SNB1" /coded_by="NM_001178324.2:1..2277" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:direct assay:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:8895471]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]" /note="Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition" /db_xref="GeneID:852194" /db_xref="SGD:S000000180" ORIGIN 1 mavnpelapf tlsrgipsfd dqalstiiql qdciqqaiqq lnystaefla ellyaecsil 61 dkssvywsda vylyalslfl nksyhtafqi skefkeyhlg iayifgrcal qlsqgvneai 121 ltllsiinvf ssnssntrin mvlnsnlvhi pdlatlncll gnlymkldhs kegafyhsea 181 lainpylwes yeaickmrat vdlkrvffdi agkksnshnn naassfpsts lshfeprsqp 241 slysktnkng nnninnnvnt lfqssnspps tsassfssiq hfsrsqqqqa ntsirtcqnk 301 ntqtpknpai nsktssalpn nismnlvsps skqptissla kvynrnkllt tppskllnnd 361 rnhqnnnnnn nnnnnnnnnn nnnnnnnnii nkttfktprn lysstgrltt skknprslii 421 snsiltsdys itlpeimynf alilrsssqy nsfkairlfe sqipshikdt mpwclvqlgk 481 lhfeiinydm slkyfnrlkd lqparvkdme ifstllwhlh dkvkssnlan glmdtmpnkp 541 etwccignll slqkdhdaai kafekatqld pnfayaytlq ghehssndss dsaktcyrka 601 lacdpqhyna yyglgtsamk lgqyeeally fekarsinpv nvvlicccgg sleklgykek 661 alqyyelach lqptsslsky kmgqllysmt rynvalqtfe elvklvpdda tahyllgqty 721 rivgrkkdai keltvamnld pkgnqviide lqkchmqe // LOCUS NP_009471 458 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009471 VERSION NP_009471.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178322.1 REFERENCE 1 (residues 1 to 458) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 458) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 458) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 458) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07041. Method: conceptual translation. FEATURES Location/Qualifiers source 1..458 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..458 /product="dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase" /EC_number="2.4.1.258" /calculated_mol_wt="52730" Region 48..417 /region_name="ALG3" /note="ALG3 protein; pfam05208" /db_xref="CDD:461587" CDS 1..458 /gene="ALG3" /locus_tag="YBL082C" /gene_synonym="RHK1" /coded_by="NM_001178322.1:1..1377" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:11308030]" /experiment="EXISTENCE:direct assay:GO:0052925 dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [PMID:11308030]" /experiment="EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:8842708]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:8842708]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:8842708]" /note="Dolichol-P-Man dependent alpha(1-3) mannosyltransferase; involved in synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins; G353A missense mutation in human ortholog ALG3 implicated in carbohydrate deficient glycoprotein syndrome type IV, which is characterized by microcephaly, severe epilepsy, minimal psychomotor development, partial deficiency of sialic acids in serum glycoproteins; wild-type human ALG3 can complement yeast alg3 mutant" /db_xref="GeneID:852196" /db_xref="SGD:S000000178" ORIGIN 1 megeqspqge kslqrkqfvr ppldlwqdlk dgvryvifdc ranlivmpll ilfesmlcki 61 iikkvaytei dykaymeqie miqldgmldy sqvsggtgpl vypaghvliy kmmywltegm 121 dhvergqvff rylylltlal qmacyyllhl ppwcvvlacl skrlhsiyvl rlfndcfttl 181 fmvvtvlgai vasrchqrpk lkkslalvis atysmavsik mnallyfpam mislfilnda 241 nviltlldlv amiawqvava vpflrsfpqq ylhcafnfgr kfmyqwsinw qmmdeeafnd 301 krfhlallis hlialttlfv tryprilpdl wsslchplrk navlnanpak tipfvliasn 361 figvlfsrsl hyqflswyhw tlpilifwsg mpffvgpiwy vlhewcwnsy ppnsqastll 421 lalntvllll laltqlsgsv alakshlrtt ssmekkln // LOCUS NP_009472 368 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL081W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009472 VERSION NP_009472.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178321.1 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 368) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07042. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..368 /product="uncharacterized protein" /calculated_mol_wt="40636" Region 1..368 /region_name="DUF5349" /note="Family of unknown function (DUF5349); pfam17298" /db_xref="CDD:407409" CDS 1..368 /locus_tag="YBL081W" /coded_by="NM_001178321.1:1..1107" /note="Non-essential hypothetical protein; null mutation results in a decrease in plasma membrane electron transport" /db_xref="GeneID:852197" /db_xref="SGD:S000000177" ORIGIN 1 mpgqiisipf lsqnedmdky lleyrslkll hqssnsfqsh napshqsnyh phynhmkynn 61 tgsyyyynnn nnssvnphnq aglqsinrsi psapygaynq nrandvpymn tqkkhhrfsa 121 nnnlnqqkyk qypqytsnpm vtahlkqtyp qlyynsnvna hnnnnnsnnn nnnnnnsnnn 181 nnlynqtqfs tryfnsnssp sltsstsnss spynqstfey ilpstsaast nlsssssnns 241 mhtnpttats tsadlindlp vgptssslis dlhspptvsf lpasqtllms sttsssigtn 301 inppqhspsp sqredfstap vnmsssasll mndsslgwgs nhmnvssssq passrpfgiw 361 ntdmsvws // LOCUS NP_009473 541 aa linear PLN 30-JUN-2025 DEFINITION glutamyl-tRNA(Gln) amidotransferase subunit PET112 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009473 VERSION NP_009473.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178320.2 REFERENCE 1 (residues 1 to 541) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 541) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 541) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 541) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07043. On Apr 26, 2011 this sequence version replaced NP_009473.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..541 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..541 /product="glutamyl-tRNA(Gln) amidotransferase subunit PET112" /calculated_mol_wt="61738" Region 24..538 /region_name="gatB" /note="aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit; TIGR00133" /db_xref="CDD:272926" CDS 1..541 /gene="PET112" /locus_tag="YBL080C" /coded_by="NM_001178320.2:1..1626" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19417106|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex [PMID:19417106]" /experiment="EXISTENCE:direct assay:GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [PMID:19417106]" /experiment="EXISTENCE:direct assay:GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation [PMID:19417106]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:8082172]" /note="Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog" /db_xref="GeneID:852198" /db_xref="SGD:S000000176" ORIGIN 1 mlrlarfysl artkaihshg apfrpeyalk cgleihtqln tknklfsqst nsatslvdap 61 nhhtsyydia lpgtqpvlnl eailfamkls lalgsqvnsi sqfdrkhyfy gdqpqgyqlt 121 qhyrpfargg kinlskeldd idesakeigi lqlqieqdtg kshytetdkd vitlvdlnrs 181 nvplielvtk pdfsdikqvr afikkyqnlv rhlhissgdl etgamrvdvn lsineyarve 241 lknlpntssi inaikyeyqr qvelisvgdt sslmepetrg wtgsstvklr skettidyry 301 mpdpelpyin lapdvisgvr glmpqlpddi mrilmkkpyq lslkdakilt ynsnqndmyn 361 healrsyyld tfrefsklag ersnaklptn wiiheflgdl nklqiplaka keilpppvfa 421 qflkllheev isatsgkmll fhilenfeqs ncqdlsipdf skliekfelh ainqvdpqel 481 mdlcndviaq htddtfirnl vtgkkksslk fligqgmrrs qgrikanefe kkfkeilniq 541 w // LOCUS NP_009474 1502 aa linear PLN 30-JUN-2025 DEFINITION Nup170p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009474 VERSION NP_009474.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178319.1 REFERENCE 1 (residues 1 to 1502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1502) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07044. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1502 /product="Nup170p" /calculated_mol_wt="169345" Region 83..1496 /region_name="NUP170" /note="Nuclear pore complex subunit [Intracellular trafficking and secretion]; COG5308" /db_xref="CDD:227624" CDS 1..1502 /gene="NUP170" /locus_tag="YBL079W" /gene_synonym="NLE3" /coded_by="NM_001178319.1:1..4509" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0044611 nuclear pore inner ring [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:23452847]" /experiment="EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:23452847]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:19414608|PMID:20498018]" /experiment="EXISTENCE:genetic interaction:GO:0051292 nuclear pore complex assembly [PMID:20498018|PMID:19414608]" /experiment="EXISTENCE:mutant phenotype:GO:0003682 chromatin binding [PMID:23452847]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11290711]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:17418788|PMID:19414606|PMID:12509452]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:23452847]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:23452847]" /experiment="EXISTENCE:mutant phenotype:GO:0036228 protein localization to nuclear inner membrane [PMID:21659568|PMID:16929305]" /experiment="EXISTENCE:mutant phenotype:GO:0099115 chromosome, subtelomeric region [PMID:23452847]" /note="Subunit of inner ring of nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; interacts with genomic regions that contain ribosomal protein and subtelomeric genes, where it functions in nucleosome positioning and as a repressor of transcription; both Nup170p and Nup157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication" /db_xref="GeneID:852199" /db_xref="SGD:S000000175" ORIGIN 1 mfqsffhnng paaagetfsd srsypltnhq evprnglnel assatkaqqq pthilnsypi 61 tgsnplmras amgatsgsin pnmsnmnehi rvsgmgtskp ldlagkyidh lqhkdsntpv 121 ldersyynsg vdynfsrekn glgaftpfek qdvfnipdei lhefstsqtk tdmgifpeln 181 rcwitidnkl ilwninndne yqvvddmkht iqkvalvrpk pntfvpavkh lllisttmel 241 fmfaisldka tnelsvfnth lsvpvqgidv idivshersg riffagqasg lniwelhysg 301 sddwfnskcs kvcltksall sllptnmlsq ipgvdfiqal fednsngngg fsqetitqlt 361 idqqrgiiys lsskstiray vitekslegp msiepayisr iigtttaraa pilgpkylki 421 vkissvapee nnnlflvalt vggvrlyfng smgrfnieal rlesikfpps svtpeviqqe 481 llhqqqeqak rsfpffsnlm ssepvllkfq kkssvllett kastiispgi ffsavikssq 541 qthqqekken ssvtgttata gsktvkqqpv tlqhklfvsv pdygilkthg kyvenatfle 601 tagpvqqiip lsglfnattk pqgfanefat qytsetlrva vltstsieiy kyrtpdeife 661 dlidnplpfv lnygaaeacs talfvtcksn kseklrsnal tfltmgipgv vdikpvynry 721 svstvsslls kptlstattn lqqsitgfsk pspankedfd lddvilsprf ygiallitrl 781 lrdiwgrhvf mtftdnrvts hafisssdpi tpsinnlksd eisqnrniis kvsiskdcie 841 yylssiniln effitygdsi sqisapyvla nnsngrvidk teevanqaes iainamikmv 901 qsikeglsfl nvlyeeseve gfdnqylgfk diisfvsldv qkdlvkldfk dlfapndktk 961 slireillsi inrnitkgas ieytatalqe rcgsfcsasd ilgfraiehl rrakeiglrn 1021 ydslnyhlkn atalleqivd dlsieklkea vsmmlsvnyy pksiefllni ansmdkgkla 1081 cqyvangfle nddrkqyydk rilvydlvfd tlikvdelae kkqssktqnq isisnddevk 1141 lrqksyeaal kyndrlfhyh mydwlvsqnr eeklldietp filpylmeka gsslkisnil 1201 wvyysrrskf fesaeilyrl atsnfditlf erieflsran gfcnsvspls qkqrivqlas 1261 riqdacevag iqgdilslvy tdaridsaik deliktldgk ilstselfnd favplsyhei 1321 alfifkiadf rdhevimakw delfqslrme fnntgkkeds mnfinllsnv likigknvqd 1381 sefifpifel fpivcnffye tlpkehivsg sivsifitag vsfnkmyyil kelietsdsd 1441 nsvfnkemtw lihewyksdr kfrdiisynd iihlkeykid ndpiekyvkn sgnnlgicfy 1501 ke // LOCUS NP_009475 117 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-like protein ATG8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009475 VERSION NP_009475.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178318.1 REFERENCE 1 (residues 1 to 117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 117) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07045. Method: conceptual translation. FEATURES Location/Qualifiers source 1..117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..117 /product="ubiquitin-like protein ATG8" /calculated_mol_wt="13496" Region 11..113 /region_name="Ubl_ATG8" /note="ubiquitin-like (Ubl) domain found in Saccharomyces cerevisiae Atg8p and related proteins; sub-family of the autophagy-related 8 (ATG8) family; cd16128" /db_xref="CDD:340545" Site order(17,20..21,28,42..46,48..52,55,58..60,62..63,66..69, 72,104) /site_type="other" /note="Atg19 interaction site [polypeptide binding]" /db_xref="CDD:340545" Site order(17,21,28,30..32,46,48..50,52,63,67,104) /site_type="other" /note="peptide binding site 2 [polypeptide binding]" /db_xref="CDD:340545" Site order(17,28,30,46,48..50,52,60,63,67,104) /site_type="other" /note="peptide binding site 1 [polypeptide binding]" /db_xref="CDD:340545" Site order(28,37..38,46,49,58..59,61..63,65..67,72..73,75..77, 79,82..84,86..88,112..113) /site_type="other" /note="Atg7 interaction site [polypeptide binding]" /db_xref="CDD:340545" Site order(36,61,65,72..77,79,82..87,108,110..113) /site_type="other" /note="Atg4 interaction site [polypeptide binding]" /db_xref="CDD:340545" CDS 1..117 /gene="ATG8" /locus_tag="YBL078C" /gene_synonym="APG8; AUT7; CVT5" /coded_by="NM_001178318.1:1..354" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:10837468]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:23129774|PMID:16680092|PMID:11689437|PMID:19398890|P MID:15659643]" /experiment="EXISTENCE:direct assay:GO:0005776 autophagosome [PMID:16079147|PMID:10525546]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:28003432]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0061025 membrane fusion [PMID:17632063]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10837468]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10837468]" /experiment="EXISTENCE:mutant phenotype:GO:0008429 phosphatidylethanolamine binding [PMID:19398890]" /experiment="EXISTENCE:mutant phenotype:GO:0016241 regulation of macroautophagy [PMID:19398890]" /experiment="EXISTENCE:mutant phenotype:GO:0031386 protein tag activity [PMID:22652539]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:22885598]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:19398890|PMID:9649430]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:25680528]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0061025 membrane fusion [PMID:17632063]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]" /experiment="EXISTENCE:mutant phenotype:GO:0071211 protein targeting to vacuole involved in autophagy [PMID:22885598]" /experiment="EXISTENCE:mutant phenotype:GO:0140042 lipid droplet formation [PMID:28003432]" /experiment="EXISTENCE:mutant phenotype:GO:1905153 regulation of membrane invagination [PMID:31616012]" /experiment="EXISTENCE:physical interaction:GO:0000329 fungal-type vacuole membrane [PMID:10837468]" /experiment="EXISTENCE:physical interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10837468]" /note="Ubiquitin-like protein conjugated to phosphatidylethanolamine (PE); role in membrane fusion and phagophore expansion during autophagosome formation; deconjugation is also required for biogenesis; targets Atg1p to autophagosomes; binds to the Atg1p-Atg13p complex, triggers its vacuolar degradation; role in vacuolar membrane protein turnover during early stationary phase; component of autophagosomes and Cvt vesicles; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:852200" /db_xref="SGD:S000000174" ORIGIN 1 mkstfkseyp fekrkaeser iadrfknrip vicekaeksd ipeidkrkyl vpadltvgqf 61 vyvirkriml ppekaififv ndtlpptaal msaiyqehkd kdgflyvtys gentfgr // LOCUS NP_009477 1072 aa linear PLN 30-JUN-2025 DEFINITION isoleucine--tRNA ligase ILS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009477 VERSION NP_009477.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178316.1 REFERENCE 1 (residues 1 to 1072) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1072) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1072) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1072) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1072) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1072) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1072) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07046. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1072 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1072 /product="isoleucine--tRNA ligase ILS1" /EC_number="6.1.1.5" /calculated_mol_wt="122853" Region 8..1037 /region_name="PLN02882" /note="aminoacyl-tRNA ligase" /db_xref="CDD:215477" CDS 1..1072 /gene="ILS1" /locus_tag="YBL076C" /coded_by="NM_001178316.1:1..3219" /experiment="EXISTENCE:direct assay:GO:0004822 isoleucine-tRNA ligase activity [PMID:7619074|PMID:782885]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:7619074]" /experiment="EXISTENCE:direct assay:GO:0006428 isoleucyl-tRNA aminoacylation [PMID:782885]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Cytoplasmic isoleucine-tRNA synthetase; target of the G1-specific inhibitor reveromycin A" /db_xref="GeneID:852202" /db_xref="SGD:S000000172" ORIGIN 1 msesnahfsf pkeeekvlsl wdeidafhts leltkdkpef sffdgppfat gtphyghila 61 stikdivpry atmtghhver rfgwdthgvp iehiidkklg itgkddvfky glenynnecr 121 sivmtyasdw rktigrlgrw idfdndyktm ypsfmestww afkqlhekgq vyrgfkvmpy 181 stglttplsn feaqqnykdv ndpavtigfn vigqektqlv awtttpwtlp snlslcvnad 241 feyvkiydet rdryfilles liktlykkpk nekykiveki kgsdlvglky eplfpyfaeq 301 fhetafrvis ddyvtsdsgt givhnapafg eednaaclkn gvisedsvlp naiddlgrft 361 kdvpdfegvy vkdadkliik yltntgnlll asqirhsypf cwrsdtplly rsvpawfvrv 421 knivpqmlds vmkshwvpnt ikekrfanwi anardwnvsr nrywgtpipl wvsddfeevv 481 cvgsikelee ltgvrnitdl hrdvidklti pskqgkgdlk rieevfdcwf esgsmpyasq 541 hypfentekf dervpanfis egldqtrgwf ytlavlgthl fgsvpyknvi vsgivlaadg 601 rkmskslkny pdpsivlnky gadalrlyli nspvlkaesl kfkeegvkev vskvllpwwn 661 sfkfldgqia llkkmsnidf qyddsvksdn vmdrwilasm qslvqfihee mgqyklytvv 721 pkllnfidel tnwyirfnrr rlkgengved clkalnslfd alftfvrama pftpflsesi 781 ylrlkeyipe avlakygkdg rsvhflsypv vkkeyfdeai etavsrmqsv idlgrnirek 841 ktislktplk tlvilhsdes ylkdvealkn yiieelnvrd vvitsdeaky gveykavadw 901 pvlgkklkkd akkvkdalps vtseqvreyl esgklevagi elvkgdlnai rglpesavqa 961 gqetrtdqdv liimdtniys elkseglare lvnriqklrk kcgleatddv lveyelvkdt 1021 idfeaivkeh fdmlsktcrs diakydgskt dpigdeeqsi ndtifklkvf kl // LOCUS NP_009478 649 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family ATPase SSA3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009478 VERSION NP_009478.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178315.1 REFERENCE 1 (residues 1 to 649) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 649) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 649) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 649) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07047. Method: conceptual translation. FEATURES Location/Qualifiers source 1..649 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..649 /product="Hsp70 family ATPase SSA3" /calculated_mol_wt="70416" Region 4..649 /region_name="PTZ00009" /note="heat shock 70 kDa protein; Provisional" /db_xref="CDD:240227" CDS 1..649 /gene="SSA3" /locus_tag="YBL075C" /gene_synonym="YG106" /coded_by="NM_001178315.1:1..1950" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10745074]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:9789005]" /experiment="EXISTENCE:genetic interaction:GO:0016887 ATP hydrolysis activity [PMID:3302682]" /experiment="EXISTENCE:genetic interaction:GO:0051082 unfolded protein binding [PMID:9789005]" /experiment="EXISTENCE:mutant phenotype:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:24855027]" /experiment="EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:8754838]" /note="ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm; SSA3 has a paralog, SSA4, that arose from the whole genome duplication" /db_xref="GeneID:852203" /db_xref="SGD:S000000171" ORIGIN 1 msravgidlg ttyscvahfs ndrveiiand qgnrttpsyv aftdterlig daaknqaain 61 phntvfdakr ligrkfddpe vttdakhfpf kvisrdgkpv vqveykgetk tftpeeissm 121 vlskmketae nylgttvnda vvtvpayfnd sqrqatkdag tiagmnvlri ineptaaaia 181 ygldkkgrae hnvlifdlgg gtfdvsllsi degvfevkat agdthlgged fdnrlvnhla 241 tefkrktkkd isnnqrslrr lrtaaerakr alssssqtsi eidslfegmd fytsltrarf 301 eelcadlfrs tlepvekvlk dskldksqid eivlvggstr ipkiqklvsd ffngkepnrs 361 inpdeavayg aavqaailtg dqstktqdll lldvaplslg ietaggimtk liprnstipt 421 kksetfstya dnqpgvliqv fegertrtkd nnllgkfels gippaprgvp qidvtfdida 481 ngilnvsale kgtgksnkit itndkgrlsk ddidrmvsea ekyraddere aervqaknql 541 esyaftlknt ineasfkekv geddakrlet asqetidwld asqaastdey kdrqkelegi 601 anpimtkfyg agagagpgag esggfpgsmp nsgatggged tgptveevd // LOCUS NP_009479 355 aa linear PLN 30-JUN-2025 DEFINITION U5 snRNP complex subunit AAR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009479 VERSION NP_009479.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178314.1 REFERENCE 1 (residues 1 to 355) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 355) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 355) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 355) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07048. Method: conceptual translation. FEATURES Location/Qualifiers source 1..355 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..355 /product="U5 snRNP complex subunit AAR2" /calculated_mol_wt="41557" Region 3..283 /region_name="AAR2" /note="AAR2 protein; pfam05282" /db_xref="CDD:461609" Region 175..313 /region_name="Aar2_C" /note="C-terminal domain of Aar2, a U5 small nuclear ribonucleoprotein particle assembly factor; cd13778" /db_xref="CDD:260100" Site order(175..178,180..182,221..222,225..226,229..230, 232..234,238,263,267,270..271) /site_type="other" /note="inter-domain interface [polypeptide binding]" /db_xref="CDD:260100" Site order(234,269..270,304,307,311) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:260100" CDS 1..355 /gene="AAR2" /locus_tag="YBL074C" /coded_by="NM_001178314.1:1..1068" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720285]" /experiment="EXISTENCE:mutant phenotype:GO:0000244 spliceosomal tri-snRNP complex assembly [PMID:11720285]" /note="Component of the U5 snRNP complex; required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron" /db_xref="GeneID:852205" /db_xref="SGD:S000000170" ORIGIN 1 mntvpftsap ievtigidqy sfnvkenqpf hgikdipigh vhvihfqhad nssmrygywf 61 dcrmgnfyiq ydpkdglykm meerdgakfe nivhnfkerq mmvsypkide ddtwynltef 121 vqmdkirkiv rkdenqfsyv dssmttvqen ellksslqka gskmeakned dpahslnytv 181 infksreair pghemedfld ksyylntvml qgifknssny fgelqfafln amffgnygss 241 lqwhamieli cssatvpkhm ldkldeilyy qiktlpeqys dillnervwn iclyssfqkn 301 slhntekime nkypellgkd neddaliygi sdeerddedd ehnptivggl yyqrp // LOCUS NP_009481 200 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS8 RPS8A [Saccharomyces cerevisiae S288C]. ACCESSION NP_009481 VERSION NP_009481.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178312.1 REFERENCE 1 (residues 1 to 200) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 200) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 200) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 200) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07049. Method: conceptual translation. FEATURES Location/Qualifiers source 1..200 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..200 /product="40S ribosomal protein eS8 RPS8A" /calculated_mol_wt="22359" Region 1..200 /region_name="PTZ00148" /note="40S ribosomal protein S8; Provisional" /db_xref="CDD:240292" CDS 1..200 /gene="RPS8A" /locus_tag="YBL072C" /coded_by="NM_001178312.1:1..603" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8A has a paralog, RPS8B, that arose from the whole genome duplication" /db_xref="GeneID:852206" /db_xref="SGD:S000000168" ORIGIN 1 mgisrdsrhk rsatgakraq frkkrkfelg rqpantkiga krihsvrtrg gnkkyralri 61 etgnfswase giskktriag vvyhpsnnel vrtntltkaa ivqidatpfr qwfeahygqt 121 lgkkknvkee etvaksknae rkwaaraasa kiessvesqf sagrlyacis srpgqsgrcd 181 gyilegeela fylrrltakk // LOCUS NP_878044 32 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL071C-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878044 VERSION NP_878044.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184584.1 REFERENCE 1 (residues 1 to 32) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 32) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 32) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 32) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 32) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 32) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 32) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07050. Method: conceptual translation. FEATURES Location/Qualifiers source 1..32 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..32 /product="uncharacterized protein" /calculated_mol_wt="3721" CDS 1..32 /locus_tag="YBL071C-B" /coded_by="NM_001184584.1:1..99" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466440" /db_xref="SGD:S000028597" ORIGIN 1 melfhirylq aylkvignyt chllfgthkk tl // LOCUS NP_660100 82 aa linear PLN 30-JUN-2025 DEFINITION Kti11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_660100 VERSION NP_660100.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184454.1 REFERENCE 1 (residues 1 to 82) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 82) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 82) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 82) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07051. Method: conceptual translation. FEATURES Location/Qualifiers source 1..82 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..82 /product="Kti11p" /calculated_mol_wt="9225" Region 1..67 /region_name="COG5216" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227541" CDS 1..82 /gene="KTI11" /locus_tag="YBL071W-A" /gene_synonym="DPH3" /coded_by="NM_001184454.1:1..249" /experiment="EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:34154323|PMID:18021800]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18627462|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:18627462]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:34154323]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:18021800]" /experiment="EXISTENCE:direct assay:GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors [PMID:18021800]" /experiment="EXISTENCE:direct assay:GO:0017183 protein histidyl modification to diphthamide [PMID:34154323]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0017183 protein histidyl modification to diphthamide [PMID:15485916]" /note="Zn-ribbon protein that co-purifies with Dph1 and Dph2; forms a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p; involved in modification of wobble nucleosides in tRNAs; forms a stable heterodimer with Ats1p" /db_xref="GeneID:852207" /db_xref="SGD:S000007587" ORIGIN 1 mstydeieie dmtfepenqm ftypcpcgdr fqiylddmfe gekvavcpsc slmidvvfdk 61 edlaeyyeea gihppepiaa aa // LOCUS NP_001333723 102 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL071C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001333723 VERSION NP_001333723.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001346794.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 102) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA79922. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..102 /product="uncharacterized protein" /calculated_mol_wt="11408" CDS 1..102 /locus_tag="YBL071C" /coded_by="NM_001346794.1:1..309" /note="hypothetical protein; conserved among S. cerevisiae strains; YBL071C is not an essential gene" /db_xref="GeneID:852208" /db_xref="SGD:S000000167" ORIGIN 1 millksehgg krkemrqddl mgpnhfslri mykiiiytyp vslyavkeln lsktfsisal 61 gilnsnsnrs pakkqtffsa cvaksyssff isicildlas hl // LOCUS NP_009484 429 aa linear PLN 30-JUN-2025 DEFINITION Ast1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009484 VERSION NP_009484.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178309.1 REFERENCE 1 (residues 1 to 429) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 429) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 429) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 429) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07052. On May 31, 2001 this sequence version replaced NP_009484.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..429 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..429 /product="Ast1p" /calculated_mol_wt="48218" Region 50..426 /region_name="AST1_like" /note="AST1 is a cytoplasmic protein associated with the periplasmic membrane in yeast; cd08247" /db_xref="CDD:176209" Site order(89..91,94,178,182,206..209,211..212,232..233,244,259, 303..304,306,326..327,365..367) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:176209" CDS 1..429 /gene="AST1" /locus_tag="YBL069W" /coded_by="NM_001178309.1:1..1290" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:11739806]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:11739806]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11739806]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:11739806]" /experiment="EXISTENCE:genetic interaction:GO:0006612 protein targeting to membrane [PMID:7822420]" /experiment="EXISTENCE:mutant phenotype:GO:0032596 protein transport into membrane raft [PMID:11739806]" /experiment="EXISTENCE:physical interaction:GO:0032596 protein transport into membrane raft [PMID:11739806]" /note="Lipid raft associated protein; interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane by influencing its incorporation into lipid rafts; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST1 has a paralog, AST2, that arose from the whole genome duplication" /db_xref="GeneID:852209" /db_xref="SGD:S000000165" ORIGIN 1 makdilknqd pklqamiveh sapapkeipm dapvlkrvar plrhvkfipi kslifhtktg 61 pmdfsyekki ktpipknkiv vrvsnvglnp vdmkirngyt ssiygeiglg reysgvitev 121 genlnyawhv gdevygiyyh phlavgclqs silvdpkvdp illrpesvsa eeaagslfcl 181 atgynilnkl sknkylkqds nvlinggtss vgmfviqllk rhyklqkklv ivtsangpqv 241 lqekfpdlad emifidyltc rgksskplrk mleekkisqy dpvedketil nynegkfdvv 301 ldfvggydil shssslihgg gayvttvgdy vanykedifd swdnpsanar kmfgsiiwsy 361 nythyyfdpn aktasanndw ieqcgdflkn gtvkcvvdkv ydwkdhkeaf symatqraqg 421 klimnvekf // LOCUS NP_009485 326 aa linear PLN 30-JUN-2025 DEFINITION ribose phosphate diphosphokinase subunit PRS4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009485 VERSION NP_009485.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178308.2 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 326) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07053. On Apr 26, 2011 this sequence version replaced NP_009485.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..326 /product="ribose phosphate diphosphokinase subunit PRS4" /EC_number="2.7.6.1" /calculated_mol_wt="35589" Region 12..321 /region_name="PrsA" /note="Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; COG0462" /db_xref="CDD:440230" CDS 1..326 /gene="PRS4" /locus_tag="YBL068W" /coded_by="NM_001178308.2:1..981" /experiment="EXISTENCE:direct assay:GO:0002189 ribose phosphate diphosphokinase complex [PMID:15280369]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004749 ribose phosphate diphosphokinase activity [PMID:15280369]" /experiment="EXISTENCE:genetic interaction:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:15280369]" /experiment="EXISTENCE:mutant phenotype:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:10212224]" /note="5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic" /db_xref="GeneID:852211" /db_xref="SGD:S000000164" ORIGIN 1 mnsesredma insikllagn shpdlaeqis kklgiplskv gvyqysnket svtigeslrd 61 edvyiiqtgi geqeindflm ellilihack iasarkittv ipnfpyarqd kkdksrapit 121 aklvanllqt agadhvitmd lhasqiqgff hipvdnlyae psvlnyirtk tdfdnailvs 181 pdaggakrva aladkldlnf alihkerqka nevskmvlvg dvtnkscllv ddmadtcgtl 241 vkacdtlmeh gakeviaivt hgifsgsare klrnsrlsri vctntvpvdl dlpiadqidi 301 sptfaeairr lhngesvsyl fthapv // LOCUS NP_009486 747 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease UBP13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009486 VERSION NP_009486.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178307.2 REFERENCE 1 (residues 1 to 747) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 747) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 747) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 747) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07054. On Apr 26, 2011 this sequence version replaced NP_009486.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..747 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..747 /product="ubiquitin-specific protease UBP13" /EC_number="3.4.19.12" /calculated_mol_wt="83725" Region 141..>165 /region_name="Peptidase_C19" /note="Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cl02553" /db_xref="CDD:470612" Region 388..666 /region_name="Peptidase_C19G" /note="A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02663" /db_xref="CDD:239128" CDS 1..747 /gene="UBP13" /locus_tag="YBL067C" /coded_by="NM_001178307.2:1..2244" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:11076031]" /experiment="EXISTENCE:mutant phenotype:GO:0010995 free ubiquitin chain depolymerization [PMID:11076031]" /note="Ubiquitin-specific protease that cleaves Ub-protein fusions; UBP13 has a paralog, UBP9, that arose from the whole genome duplication" /db_xref="GeneID:852212" /db_xref="SGD:S000000163" ORIGIN 1 mirrwltisk sgkkkkavnd titeevekvd fkpvnhdind elcysessdn pssslfvsnl 61 dtketflned nnlqissgld yssetcnqgs nysqdgifyi snakainayg giitqgpeap 121 ilamkvsdsm pygdgsnkvf gyenfgntcy cnsvlqclyn lsslrenilq fpkksresdq 181 prkkemrgkk prifteasfe ksiagtnghl pnpkpqsvdd gkptpvnsvn sntagpsekk 241 skffksfsak hvqdnnkkeg spailttgkp ssrpqdappl ivetpnepga psrlsfenvt 301 drppdvprki ivgrvlnyen psrgssnsnn ldlkgesnss lstpldkkdt rrsssssqis 361 pehrkksali rgpvlnidhs lngsdkatly sslrdifeci tentyltgvv spssfvdvlk 421 renvlfnttm hqdaheffnf llnelseyie renkkiaasd insdsepsks knfisdlfqg 481 tltnqikclt cdnitsrdep fldfpievqg deetdiqeil ksyhqremln gsnkfycdec 541 cglqeaerlv glkqlpdtlt lhlkrfkyse kqncniklfn nihypltlnv cssinskvcq 601 kyelagivvh mgggpqhghy vslckhekfg wllfddetve avkeetvlef tgespnmata 661 yvlfykamys navekndren makeqddnid nlikyddwlr tcnsgqkkke elpiaddldt 721 aiddsfvsnt piksskkksr mfsfrks // LOCUS NP_009487 1148 aa linear PLN 30-JUN-2025 DEFINITION Sef1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009487 VERSION NP_009487.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178306.1 REFERENCE 1 (residues 1 to 1148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1148) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07055. On Jul 26, 2004 this sequence version replaced NP_009487.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1148 /product="Sef1p" /calculated_mol_wt="127861" Region 51..96 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(52,56,61..64,66,69,82) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(57,60,67,77,80,87) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 353..577 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..1148 /gene="SEF1" /locus_tag="YBL066C" /coded_by="NM_001178306.1:1..3447" /note="Putative transcription factor; has homolog in Kluyveromyces lactis" /db_xref="GeneID:852214" /db_xref="SGD:S000000162" ORIGIN 1 mvkdnrdsdq dqdfssahmk rqpeqqqlqq hqfpskkqri shhddshqin hrpvtscthc 61 rqhkikcdas qnfphpcsrc ekiglhcein pqfrpkkgsq lqllrqdvde ikskldtlla 121 ndsvfvhllq qipmgnslln klnlhptptp gtiipnpdss pssgsptssa aqrdskvsvq 181 tylsrepqll qanqgsntnk fkanneassh mtlrasslaq dskglvatep nklppllnds 241 alpnnskesl ppalqmafyk nnsagntpng pfspiqktys phttsttvtt ttnqppfaat 301 shvatnnnad rtktpvvatt ttmpllpsph anvdefvlgd isisiekanr lhhifvtryl 361 pyfpimysnn atelysqsql lfwtvmltac lsdpeptmyc klsslikqla ietcwirtpr 421 sthisqalli lciwplpnqk vlddcsyrfv glakslsyql glhrgefise ftrtqtsmpn 481 aekwrtrtwl giffaelcwa silglpptsq tdyllekals cgdeeseedn ndsidnnnnd 541 krnkkdephv eskyklpgsf rrllslanfq aklshiigss tsspdgllep kyraetlsil 601 gkeldllakt lnfqsddtvn iyflyvkltv ccfaflpetp ptdqipyvte ayltatkivt 661 llnnllethq lielpiyirq aatfsalilf klqltpllpd kyfdsarqsv vtihrlyrnq 721 ltawatsven disrtasmle klnfvlimhp evfveedgii srmrshltgs lfydlvwcvh 781 earrremdpe ynkqalekaa kkrkfssngi yngtsstggi tdrklyplpl ynhisrddfe 841 tvtkttpsgt tvttlvptkn alkqaeklak tnngdsdgsi meingiplsm lgetgsvkfq 901 slfantsnsn dynnnrtlld asndisipsn siypvasvpa snnnpqstkv dyysngpsvi 961 pdlsmkrsvs tpvnhfpasv pglrnhpvgn lsnnvtlgid hpiprehsnl qnvtmnynnq 1021 fsnanaigrs qssmshsrtp iasksnnmtd lhsvvsdpgs skstayppls lfsksndins 1081 nktnqrfstg tntvtssnfq tidnennvkt pgnkltdffq qqsagwiegn ssnddffgwf 1141 dmnmeqgf // LOCUS NP_009489 261 aa linear PLN 30-JUN-2025 DEFINITION thioredoxin peroxidase PRX1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009489 VERSION NP_009489.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178304.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 261) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07056. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..261 /product="thioredoxin peroxidase PRX1" /EC_number="1.11.1.25" /EC_number="1.11.1.27" /calculated_mol_wt="29365" Region 51..259 /region_name="PRX_1cys" /note="Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; cd03016" /db_xref="CDD:239314" Site order(51,89,92..94,97,129,132,156,173,187..189,191..193, 195..200,202,205,209..210,219..220,222..223,254,257) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:239314" Site order(63,117..119,121..122,124..125,127..128,137,147..148, 158,171..172,235,252) /site_type="other" /note="decamer (pentamer of dimers) interface [polypeptide binding]" /db_xref="CDD:239314" Site order(88,91,175) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:239314" CDS 1..261 /gene="PRX1" /locus_tag="YBL064C" /coded_by="NM_001178304.1:1..786" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:10821871|PMID:24769239|P MID:10681558]" /experiment="EXISTENCE:direct assay:GO:0008379 thioredoxin peroxidase activity [PMID:10681558|PMID:10821871]" /experiment="EXISTENCE:direct assay:GO:0045454 cell redox homeostasis [PMID:10681558]" /experiment="EXISTENCE:mutant phenotype:GO:0008379 thioredoxin peroxidase activity [PMID:10681558]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:10681558]" /note="Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852215" /db_xref="SGD:S000000160" ORIGIN 1 mfsricsaql krtawtlpkq ahlqsqtikt fatapilckq fkqsdqprlr insdapnfda 61 dttvgkinfy dylgdswgvl fshpadftpv cttevsafak lkpefdkrnv kliglsvedv 121 eshekwiqdi keiakvknvg fpiigdtfrn vaflydmvda egfknindgs lktvrsvfvi 181 dpkkkirlif typstvgrnt sevlrvidal qltdkegvvt pinwqpaddv iippsvsnde 241 akakfgqfne ikpylrftks k // LOCUS NP_009490 1111 aa linear PLN 30-JUN-2025 DEFINITION Kip1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009490 VERSION NP_009490.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178303.1 REFERENCE 1 (residues 1 to 1111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1111) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07057. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1111 /product="Kip1p" /calculated_mol_wt="125664" Region 50..419 /region_name="KISc_BimC_Eg5" /note="Kinesin motor domain, BimC/Eg5 spindle pole proteins; cd01364" /db_xref="CDD:276815" Site order(60,141,144,146..149,316) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:276815" Site order(363,366,369) /site_type="other" /note="microtubule interaction site [polypeptide binding]" /db_xref="CDD:276815" Region <423..>948 /region_name="235kDa-fam" /note="reticulocyte binding/rhoptry protein; TIGR01612" /db_xref="CDD:130673" Region <562..>741 /region_name="AAA_13" /note="AAA domain; pfam13166" /db_xref="CDD:463796" CDS 1..1111 /gene="KIP1" /locus_tag="YBL063W" /gene_synonym="CIN9" /coded_by="NM_001178303.1:1..3336" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:16533946]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:1618910]" /experiment="EXISTENCE:direct assay:GO:1990537 mitotic spindle polar microtubule [PMID:16533946]" /experiment="EXISTENCE:genetic interaction:GO:0000070 mitotic sister chromatid segregation [PMID:7860634]" /experiment="EXISTENCE:genetic interaction:GO:0000073 initial mitotic spindle pole body separation [PMID:1618897|PMID:1618910]" /experiment="EXISTENCE:genetic interaction:GO:0000089 mitotic metaphase [PMID:16533946]" /experiment="EXISTENCE:genetic interaction:GO:0003777 microtubule motor activity [PMID:1618910]" /experiment="EXISTENCE:genetic interaction:GO:0098653 centromere clustering [PMID:16533946]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:9813090]" /experiment="EXISTENCE:mutant phenotype:GO:0007019 microtubule depolymerization [PMID:19041752]" /experiment="EXISTENCE:mutant phenotype:GO:0030543 2-micrometer plasmid partitioning [PMID:19364922]" /experiment="EXISTENCE:mutant phenotype:GO:0090307 mitotic spindle assembly [PMID:9813090]" /note="Kinesin-related motor protein; tracks plus-ends and stabilizes microtubules; required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; involved in centromere clustering on the metaphase spindle; functionally redundant with Cin8p for chromosomal but not plasmid functions" /db_xref="GeneID:852216" /db_xref="SGD:S000000159" ORIGIN 1 marsslpnrr taqfeankrr tiahapspsl sngmhtltpp tcnngaatsd snihvyvrcr 61 srnkreieek ssvvistlgp qgkeiilsng shqsyssskk tyqfdqvfga esdqetvfna 121 taknyikeml hgynctifay gqtgtgktyt msgdinilgd vqstdnlllg ehagiiprvl 181 vdlfkelssl nkeysvkisf lelynenlkd llsdsedddp avndpkrqir ifdnnnnnss 241 imvkgmqeif insaheglnl lmqgslkrkv aatkcndlss rshtvftitt niveqdskdh 301 gqnknfvkig klnlvdlags eninrsgaen kraqeaglin kslltlgrvi nalvdhsnhi 361 pyreskltrl lqdslggmtk tciiatispa kismeetast leyatraksi kntpqvnqsl 421 skdtclkdyi qeieklrndl knsrnkqgif itqdqldlye snsilideqn lkihnlreqi 481 kkfkenylnq ldinnllqse kekliaiiqn fnvdfsnfys eiqkihhtnl elmneviqqr 541 dfslensqkq yntnqnmqlk isqqvlqtln tlqgslnnyn skcsevikgv teeltrnvnt 601 hkakhdstlk sllnittnll mnqmnelvrs istsleifqs dstshyrkdl neiyqshqqf 661 lknlqndiks cldsigssil tsineisqnc ttnlnsmnvl ienqqsgssk likeqdleik 721 klkndliner risnqfnqql aemkryfqdh vsrtrsefhd elnkcidnlk dkqskldqdi 781 wqktasifne tdivvnkihs dsiaslahna entlktvsqn nesftndlis lsrgmnmdis 841 sklrslpine flnkisqtic etcgddntia snpvltsikk fqniicsdia ltnekimsli 901 deiqsqieti snenninlia inenfnslcn filtdydeni mqisktqdev lsehceklqs 961 lkilgmdift ahsiekplhe htrpeasvik alplldypkq fqiyrdaenk skddtsnsrt 1021 cipnlstnen fplsqfspkt pvpvpdqplp kvlipksins aksnrsktlp ntegtgresq 1081 nnlkrrftte pilkgeeten ndilqnkklh q // LOCUS NP_009492 696 aa linear PLN 30-JUN-2025 DEFINITION Skt5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009492 VERSION NP_009492.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178301.1 REFERENCE 1 (residues 1 to 696) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 696) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 696) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 696) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 696) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 696) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 696) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07058. Method: conceptual translation. FEATURES Location/Qualifiers source 1..696 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..696 /product="Skt5p" /calculated_mol_wt="76936" Region 254..283 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 281..530 /region_name="TPR" /note="TPR repeat [General function prediction only]; COG0790" /db_xref="CDD:440553" Region 290..319 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 326..355 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 407..436 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 444..473 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 482..511 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" CDS 1..696 /gene="SKT5" /locus_tag="YBL061C" /gene_synonym="CAL2; CHS4; CSD4" /coded_by="NM_001178301.1:1..2091" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15470103]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:9314530|PMID:15470103]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:9234668|PMID:17142567]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:9234668]" /note="Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication" /db_xref="GeneID:852218" /db_xref="SGD:S000000157" ORIGIN 1 masspqvhpy kkhlmqsqhi nfdnrglqfq nsslkvgqdf sdnkenrenr dnedfstadl 61 pkrsanqpli nehlraasvp llsndignsq eedfvpvppp qlhlnnsnnt slsslgstpt 121 nspspgalrq tnsstsltke qikkrtrsvd lshmyllngs sdtqltatne svadlshqmi 181 srylggknnt slvprlktie myrqnvkksk dpevlfqyaq ymlqtaltie ssnalvqdsd 241 kegnvsqsdl klqflkeaqs ylkklsikgy sdaqylladg yssgafgkie nkeafvlfqa 301 aakhghiesa yrashcleeg lgttrdsrks vnflkfaasr nhpsamyklg lysfygrmgl 361 ptdvntklng vkwlsraaar aneltaaapy elakiyhegf ldvvipdeky amelyiqaas 421 lghvpsatll aqiyetgndt vgqdtslsvh yytqaalkgd svamlglcaw yllgaepafe 481 kdeneafqwa lraanaglpk aqftlgyfye hgkgcdrnme yawkwyekaa gnedkraink 541 lrsrdgglas igkkqhkknk sistlnlfst vdsqtsnvgs nsrvsskset fftgnpkrdr 601 epqglqinmn sntnrngikt gsdtsirkss ssakgmsrev aeqsmaakqe vslsnmgssn 661 mirkdfpavk teskkptslk nkkdkqgkkk kdcvim // LOCUS NP_009493 687 aa linear PLN 30-JUN-2025 DEFINITION Arf family guanine nucleotide exchange factor YEL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009493 VERSION NP_009493.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178300.1 REFERENCE 1 (residues 1 to 687) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 687) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 687) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 687) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07059. Method: conceptual translation. FEATURES Location/Qualifiers source 1..687 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..687 /product="Arf family guanine nucleotide exchange factor YEL1" /calculated_mol_wt="78637" Region 48..266 /region_name="Sec7" /note="Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor...; cd00171" /db_xref="CDD:238100" Site order(156..163,194..207) /site_type="active" /note="active site/putative ARF binding site [active]" /db_xref="CDD:238100" CDS 1..687 /gene="YEL1" /locus_tag="YBL060W" /coded_by="NM_001178300.1:1..2064" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17786213]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17786213]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17786213|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:18397879]" /experiment="EXISTENCE:mutant phenotype:GO:0010513 positive regulation of phosphatidylinositol biosynthetic process [PMID:18208507]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:18397879]" /note="Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip" /db_xref="GeneID:852219" /db_xref="SGD:S000000156" ORIGIN 1 mcaslnevkk ndtygvsqkg yndnfseseg vlhgsksmpt smknmlqspt mvnmcdilqn 61 keaandekpv ipttdtatag tgtedisstq seetdqnshl iaseilegtf kdvsykeyan 121 flgndnnnqv ltefvkllsp lpsslletlf nlsksiyfia eaqnidrile clsiewiach 181 pnthwksgyk schivlfsll ilnsdlhnnf qvdhkkikfs mvafinntlr alreeneyee 241 lkiysrehli ieelseyykt lnetplplct esrtsinisd nqsslkrfst lgsrefstsn 301 lrsvnsnstt lysrdgqvsv remsaksnkn fhnnhpmdal ylkesfddgl itengsswfm 361 ddliliskks lprkyskrdk dqvaapkmts krnksffgwl kpsktttlie htsrrtslsy 421 lnkdsewerv kiqvkegrif ifkikpdvkd iiqssetdsa tidyfkdiss syfaysllea 481 eahvvqdnii igsgamksnv cnkntkrksg nftvsfpeni ngpklvlefq trsveeahkf 541 mdcinfwagr ispvpltqfe avsnaeygws dkiltehasl nlknivvsew kpllglelly 601 edakdvemve lkerlkelmn ftrqlgiwid khneikdklv eiwsfddnyf eavmnnwnsr 661 ylymnnqykk rlsylkalqk amgsvqf // LOCUS NP_031358 109 aa linear PLN 30-JUN-2025 DEFINITION Cmc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_031358 VERSION NP_031358.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184440.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 109) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07060. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..109 /product="Cmc2p" /calculated_mol_wt="12816" Region 1..70 /region_name="Cmc1" /note="Cytochrome c oxidase biogenesis protein Cmc1 like; pfam08583" /db_xref="CDD:400756" CDS 1..109 /gene="CMC2" /locus_tag="YBL059C-A" /coded_by="NM_001184440.1:1..330" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:19703468]" /experiment="EXISTENCE:mutant phenotype:GO:0033108 mitochondrial respiratory chain complex assembly [PMID:19703468]" /note="Protein involved in respiratory chain complex assembly or maintenance; protein of the mitochondrial intermembrane space; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold" /db_xref="GeneID:852220" /db_xref="SGD:S000007488" ORIGIN 1 mhpqleaerf hscldfinal dkchqkeyyk rifglcnnek dalnkclkea slnnkkravi 61 esrikradve krwkkieeee ygedailkti ldrqyakkkq esdndansk // LOCUS NP_009494 193 aa linear PLN 30-JUN-2025 DEFINITION Iai11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009494 VERSION NP_009494.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178299.1 REFERENCE 1 (residues 1 to 193) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 193) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 193) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 193) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07061. Method: conceptual translation. FEATURES Location/Qualifiers source 1..193 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..193 /product="Iai11p" /calculated_mol_wt="22147" CDS 1..193 /gene="IAI11" /locus_tag="YBL059W" /coded_by="NM_001178299.1:1..582" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762|PMID:16823961|PMID:14562095]" /note="Putative mitochondrial hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; IAI11 has a paralog, YER093C-A, that arose from the whole genome duplication" /db_xref="GeneID:852221" /db_xref="SGD:S000000155" ORIGIN 1 mlldaqrffn rsfsinvice lkhnvntrrk feikdwptim lvsrndkpki sseevthfid 61 dykkrrktqm trffgitift litcriamkk mitakvplnt fqanyasrtq tithtqksla 121 gsllaatgmt lgifgmgitg tcwswdvssf qelkqrlerr annefvvtnm pldkrsqqvv 181 dslvkthnss lck // LOCUS NP_009495 423 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase regulator SHP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009495 VERSION NP_009495.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178298.1 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 423) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07062. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..423 /product="protein phosphatase regulator SHP1" /calculated_mol_wt="46856" Region 6..41 /region_name="UBA_Ubx1_like" /note="UBA-like domain found in yeast UBX domain-containing protein 1 (Ubx1) and similar proteins; cd14351" /db_xref="CDD:270536" Region 231..323 /region_name="SEP" /note="Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47; smart00553" /db_xref="CDD:197786" Region 350..421 /region_name="UBX_UBXN2" /note="Ubiquitin regulatory domain X (UBX) found in UBX domain-containing proteins UBXN2A, UBXN2B, NSFL1C/UBXN2C, and similar proteins; cd01770" /db_xref="CDD:340468" Site order(350,352,354..355,358..359,361,395..396,398,414..417, 419,421) /site_type="other" /note="UBX-p97 interaction site [polypeptide binding]" /db_xref="CDD:340468" CDS 1..423 /gene="SHP1" /locus_tag="YBL058W" /gene_synonym="UBX1" /coded_by="NM_001178298.1:1..1272" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:20855502]" /experiment="EXISTENCE:mutant phenotype:GO:0005977 glycogen metabolic process [PMID:7891699]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:23418575|PMID:7891699]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:7891699]" /experiment="EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:20483956]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:20855502]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:21148305]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:15258615]" /note="Substrate adaptor for Cdc48p; ubiquitin regulatory X (UBX) and Ub-associated (UBA) domain-containing protein that acts as a substrate recruiting cofactor; K48-specific Ub chain binding protein involved in ER-associated degradation (ERAD); positively regulates Glc7p protein phosphatase activity to promote growth and mitotic progression in complex with Cdc48p; regulated by nuclear Ub-dependent degradation (INMAD pathway) independent of the Asi and Doa10 complexes; homolog of human p47 (NSFL1C)" /db_xref="GeneID:852222" /db_xref="SGD:S000000154" ORIGIN 1 maeipdetiq qfmaltnvsh niavqylsef gdlnealnsy yasqtddqkd rreeahwnrq 61 qekalkqeaf stnssnkain tehvgglcpk pgssqgsney lkrkgstspe ptkgssrsgs 121 gnnsrfmsfs dmvrgqaddd dedqprntfa ggetsglevt dpsdpnsllk dllekarrgg 181 qmgaengfrd dedhemganr ftgrgfrlgs tidaadevve dntsqsqrrp ekvtreitfw 241 kegfqvadgp lyryddpans fylselnqgr aplklldvqf gqevevnvyk kldesykapt 301 rklggfsgqg qrlgspipge sspaevpkne tpaaqeqpmp dnepkqgdts iqiryangkr 361 evlhcnstdt vkflyehvts nantdpsrnf tlnyafpikp isndettlkd adllnsvvvq 421 rwa // LOCUS NP_009496 208 aa linear PLN 30-JUN-2025 DEFINITION aminoacyl-tRNA hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009496 VERSION NP_009496.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178297.2 REFERENCE 1 (residues 1 to 208) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 208) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 208) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 208) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07063. On Apr 26, 2011 this sequence version replaced NP_009496.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..208 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..208 /product="aminoacyl-tRNA hydrolase" /EC_number="3.1.1.29" /calculated_mol_wt="22304" Region 88..208 /region_name="arch_pth2" /note="peptidyl-tRNA hydrolase; TIGR00283" /db_xref="CDD:161803" Site order(102,109..111,114,117..118,121,138,144,208) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:239108" Site order(104,108,111,144,186) /site_type="active" /note="putative active site [active]" /db_xref="CDD:239108" CDS 1..208 /gene="PTH2" /locus_tag="YBL057C" /coded_by="NM_001178297.2:1..627" /experiment="EXISTENCE:direct assay:GO:0004045 peptidyl-tRNA hydrolase activity [PMID:12799450]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process [PMID:17082762]" /experiment="EXISTENCE:genetic interaction:GO:0004045 peptidyl-tRNA hydrolase activity [PMID:12475929]" /experiment="EXISTENCE:mutant phenotype:GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process [PMID:17082762]" /note="One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1" /db_xref="GeneID:852223" /db_xref="SGD:S000000153" ORIGIN 1 mekmtvssny tialwatfta isfavgyqlg tsnasstkks satllrskem kegklhndtd 61 eeesesedes dedediests lndipgevrm alvirqdlgm tkgkiaaqcc haalscfrhi 121 atnparasyn pimtqrwlna gqakitlkcp dkftmdelya kaislgvnaa vihdagrtqi 181 aagsatvlgl gpapkavldq itgdlkly // LOCUS NP_009497 468 aa linear PLN 30-JUN-2025 DEFINITION type 2C protein phosphatase PTC3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009497 VERSION NP_009497.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178296.2 REFERENCE 1 (residues 1 to 468) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 468) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 468) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 468) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07064. On Apr 26, 2011 this sequence version replaced NP_009497.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..468 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..468 /product="type 2C protein phosphatase PTC3" /EC_number="3.1.3.16" /calculated_mol_wt="51201" Region 23..280 /region_name="PP2C" /note="Protein phosphatase 2C; pfam00481" /db_xref="CDD:395385" Site order(33,37..38,62..64,234,284) /site_type="active" /db_xref="CDD:238083" CDS 1..468 /gene="PTC3" /locus_tag="YBL056W" /coded_by="NM_001178296.2:1..1407" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:10580002]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:12477803]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12477803|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:10580002]" /note="Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation; PTC3 has a paralog, PTC2, that arose from the whole genome duplication" /db_xref="GeneID:852224" /db_xref="SGD:S000000152" ORIGIN 1 mgqilsnpii dkehhsgtdc ltafglcamq gwrmsmedah ivepnllaes deehlafygi 61 fdghggssva efcgskmisi lkkqesfksg mleqclidtf latdvellkd eklkddhsgc 121 tatvilvsql kkllicansg dsrtvlstgg nskamsfdhk ptllseksri vaadgfvemd 181 rvngnlalsr aigdfefksn tklgpheqvv tcvpdiichn lnydedefvi lacdgiwdcl 241 tsqecvdlvh ygisqgnmtl sdissrivdv ccspttegsg igcdnmsisi vallkenese 301 sqwfermrsk nyniqtsfvq rrksifdfhd fsdddnevfa ittkklqdrl nrskdnddme 361 iddldtelgs satpsklsge drtgpidlfs lealleagiq irqrpssdsd gntsyfhgas 421 lsdmlaslsn aaagetepnd addnddndge engknenakk gskieeie // LOCUS NP_009498 418 aa linear PLN 30-JUN-2025 DEFINITION 3'-5'-exodeoxyribonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_009498 VERSION NP_009498.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178295.1 REFERENCE 1 (residues 1 to 418) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 418) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 418) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 418) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07065. Method: conceptual translation. FEATURES Location/Qualifiers source 1..418 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..418 /product="3'-5'-exodeoxyribonuclease" /calculated_mol_wt="47259" Region 38..417 /region_name="TatD_DNAse" /note="TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; cd01310" /db_xref="CDD:238635" Site order(42,44,226,277,327) /site_type="active" /db_xref="CDD:238635" CDS 1..418 /locus_tag="YBL055C" /coded_by="NM_001178295.1:1..1257" /experiment="EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:15657035]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008296 3'-5'-DNA exonuclease activity [PMID:15657035]" /experiment="EXISTENCE:mutant phenotype:GO:0006309 apoptotic DNA fragmentation [PMID:15657035]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15657035]" /note="3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases" /db_xref="GeneID:852225" /db_xref="SGD:S000000151" ORIGIN 1 mwgillkssn kscsrlwkpi ltqyysmtst atdsplkyyd iglnltdpmf hgiyngkqyh 61 padyvkller aaqrhvknal vtgssiaesq saielvssvk dlsplklyht igvhpccvne 121 fadasqgdka sasidnpsmd eayneslyak visnpsfaqg klkelydlmn qqakphdtsf 181 rsigeigldy drfhysskem qkvffeeqlk isclndklss yplflhmrsa cddfvqiler 241 fiagftderd tfqlqklgas sssgfykfhp drklvvhsft gsaidlqkll nlspnifigv 301 ngcslrteen lavvkqipte rllletdapw ceikrthasf qylakyqevr dfeypafksv 361 kknkladkln aeelymvkgr nepcnmeqva ivvsevkdvd latlidttwk ttckifge // LOCUS NP_009499 525 aa linear PLN 30-JUN-2025 DEFINITION Tod6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009499 VERSION NP_009499.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178294.1 REFERENCE 1 (residues 1 to 525) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 525) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 525) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 525) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07066. Method: conceptual translation. FEATURES Location/Qualifiers source 1..525 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..525 /product="Tod6p" /calculated_mol_wt="59095" Region 77..120 /region_name="SANT" /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167" /db_xref="CDD:238096" Site order(78,107..108,110..111,113..115,117..119) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238096" CDS 1..525 /gene="TOD6" /locus_tag="YBL054W" /gene_synonym="PBF1" /coded_by="NM_001178294.1:1..1578" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19158363]" /note="PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manner; activated in stochastic pulses of nuclear localization" /db_xref="GeneID:852226" /db_xref="SGD:S000000150" ORIGIN 1 mtlpklssvs vssghvsans hgfsilskhp hpnnlvhshs lshtnakshl pisststken 61 stnkeeaesl kknnpsswdp sddiklrhlk eiknlgwkei ahhfpnrtpn acqfrwrrlk 121 sgnlksnkta vidinklfgv yatgdatpsa gtpsaeeavk eeavededit agssaiedsp 181 pdfkplvkpk ymdrklitqr ststfsdhep qhtkprklfv kprsfshsit tntpnvktaq 241 qtnlslyntt saktnkavns ndyeniglvp kiiirsrrns fipstqiphs ttktrknshs 301 vissrrssfn mmhsrrssfn shaptepisr raslvvspym sprrlstsqs vhyhpqhqyy 361 lnpiaspnck tdhandkith trtfldmqkf ankhpwsred devllnntkd kqnhlsplei 421 sivlpnnrse leiqqrmdyl krkgrvsgfh tnegckdeee eddidplhke ngintpsqqs 481 qnygmleakh dnpksselss mtsandirne qdelpginsi fknif // LOCUS NP_009501 831 aa linear PLN 30-JUN-2025 DEFINITION histone acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009501 VERSION NP_009501.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178292.1 REFERENCE 1 (residues 1 to 831) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 831) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 831) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 831) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 831) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 831) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 831) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07067. Method: conceptual translation. FEATURES Location/Qualifiers source 1..831 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..831 /product="histone acetyltransferase" /EC_number="2.3.1.48" /calculated_mol_wt="97452" Region 67..571 /region_name="SAS2" /note="Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]; COG5027" /db_xref="CDD:227360" CDS 1..831 /gene="SAS3" /locus_tag="YBL052C" /gene_synonym="KAT6" /coded_by="NM_001178292.1:1..2496" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:10817755]" /experiment="EXISTENCE:direct assay:GO:0033100 NuA3 histone acetyltransferase complex [PMID:17157260|PMID:10817755]" /experiment="EXISTENCE:direct assay:GO:1990467 NuA3a histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:direct assay:GO:1990468 NuA3b histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:mutant phenotype:GO:0004402 histone acetyltransferase activity [PMID:10817755]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11731479]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11731479]" /note="Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal" /db_xref="GeneID:852228" /db_xref="SGD:S000000148" ORIGIN 1 msltandesp kpkknallkn leiddlihsq fvrsdtnghr ttrrlfnsda sishrirgsv 61 rsdkglnkik kglisqqskl asenssqniv nrdnkmgavs fpiiepniev seelkvriky 121 dsikffnfer liskssviap lvnknitssg pligfqrrvn rlkqtwdlat enmeypyssd 181 ntpfrdndsw qwyvpyggti kkmkdfstkr tlptwedkik fltflensks atyingnvsl 241 cnhnetdqen edrkkrkgkv priknkvwfs qieyivlrny eikpwytspf pehinqnkmv 301 ficefclkym tsrytfyrhq lkcltfkppg neiyrdgkls vweidgrenv lycqnlclla 361 kcfinsktly ydvepfifyi lteredtenh pyqnaakfhf vgyfskekfn sndynlscil 421 tlpiyqrkgy gqflmefsyl lsrkeskfgt pekplsdlgl ltyrtfwkik caevllklrd 481 sarrrsnnkn edtfqqvsln diakltgmip tdvvfgleql qvlyrhktrs lsslddfnyi 541 ikidswnrie niyktwsskn yprvkydkll wepiilgpsf gingmmnlep taladealtn 601 etmapvisnn thienynnsr ahnkrrrrrr rssehktskl hvnniiepev patdffedtv 661 sslteymcdy kntnndrliy qaekrvlesi hdrkgiprsk fstethwelc ftiknsetpl 721 gnhaarrndt gissleqdev endvdtelyv genakedede dedftldddi edeqiseend 781 eeedtyeeds dddedgkrkg qeqdendies hirkervrkr rkitliedde e // LOCUS NP_009502 668 aa linear PLN 30-JUN-2025 DEFINITION Pin4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009502 VERSION NP_009502.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178291.1 REFERENCE 1 (residues 1 to 668) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 668) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 668) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 668) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07068. Method: conceptual translation. FEATURES Location/Qualifiers source 1..668 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..668 /product="Pin4p" /calculated_mol_wt="73645" Region 84..162 /region_name="RRM_PIN4_like" /note="RNA recognition motif (RRM) found in yeast RNA-binding protein PIN4, fission yeast RNA-binding post-transcriptional regulators cip1, cip2 and similar proteins; cd12253" /db_xref="CDD:240699" Region 305..367 /region_name="R3H_RRM" /note="R3H domain of mainly fungal proteins which are associated with a RNA recognition motif (RRM) domain. Present in this group is the RNA-binding post-transcriptional regulator Cip2 (Csx1-interacting protein 2) involved in counteracting Csx1 function. Csx1...; cd02639" /db_xref="CDD:100068" Site order(336,340) /site_type="other" /note="RxxxH motif" /db_xref="CDD:100068" CDS 1..668 /gene="PIN4" /locus_tag="YBL051C" /gene_synonym="MDT1" /coded_by="NM_001178291.1:1..2007" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000077 DNA damage checkpoint signaling [PMID:15024067]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:15024067]" /experiment="EXISTENCE:physical interaction:GO:0000077 DNA damage checkpoint signaling [PMID:15024067]" /note="Protein involved in G2/M phase progression and response to DNA damage; interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage" /db_xref="GeneID:852229" /db_xref="SGD:S000000147" ORIGIN 1 metssfenap paaindaqdn nintetndqe tnqqsietrd aidkengvqt etgensakna 61 eqnvsstnln naptngaldd dvipnaivik nipfaikkeq lldiieemdl plpyafnyhf 121 dngifrglaf anfttpeett qvitslngke isgrklkvey kkmlpqaere rierekrekr 181 gqleeqhrss snlsldslsk msgsgnnnts nnqlfstlmn ginansmmns pmnntinnns 241 snnnnsgnii lnqpslsaqh tssslyqtnv nnqaqmster fyaplpstst lplppqqldf 301 ndpdtleiys qlllfkdrek yyyelaypmg isashkriin vlcsylglve vydprfiiir 361 rkildhanlq shlqqqgqmt sahplqpnst ggsmnrsqsy tsllqahaaa aansisnqav 421 nnssnsntin snngngnnvi innnsasstp kissqgqfsm qptltspkmn ihhssqynsa 481 dqpqqpqpqt qqnvqsaaqq qqsflrqqat ltpssripsg ysanhyqins vnpllrnsqi 541 sppnsqipin sqtlsqaqpp aqsqtqqrvp vayqnaslss qqlynlngps sansqsqllp 601 qhtngsvhsn fsyqsyhdes mlsahnlnsa dliykslshs glddgleqgl nrslsgldlq 661 nqnkknlw // LOCUS NP_009503 292 aa linear PLN 30-JUN-2025 DEFINITION alpha-soluble NSF attachment protein SEC17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009503 VERSION NP_009503.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178290.1 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 292) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07069. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..292 /product="alpha-soluble NSF attachment protein SEC17" /calculated_mol_wt="32672" Region 10..284 /region_name="SNAP" /note="Soluble NSF attachment protein, SNAP; pfam14938" /db_xref="CDD:405606" CDS 1..292 /gene="SEC17" /locus_tag="YBL050W" /gene_synonym="RNS3" /coded_by="NM_001178290.1:1..879" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:10387016]" /experiment="EXISTENCE:direct assay:GO:0005483 soluble NSF attachment protein activity [PMID:11994317]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8636207]" /experiment="EXISTENCE:direct assay:GO:0035494 SNARE complex disassembly [PMID:18650938|PMID:9425154]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:8670830|PMID:9685264]" /experiment="EXISTENCE:direct assay:GO:0048280 vesicle fusion with Golgi apparatus [PMID:1601878]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:11694599]" /experiment="EXISTENCE:physical interaction:GO:0005483 soluble NSF attachment protein activity [PMID:10387016]" /experiment="EXISTENCE:physical interaction:GO:0031201 SNARE complex [PMID:10397773]" /note="Alpha-SNAP cochaperone; SNARE-complex adaptor for Sec18 (NSF) during the disassembly of postfusion cis-SNARE complexes; stimulates the ATPase activity of Sec18p; peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; similar to mammalian alpha-SNAP" /db_xref="GeneID:852230" /db_xref="SGD:S000000146" ORIGIN 1 msdpvellkr aekkgvpssg fmklfsgsds ykfeeaadlc vqaatiyrlr kelnlagdsf 61 lkaadyqkka gnedeagnty veaykcfksg gnsvnavdsl enaiqifthr gqfrrganfk 121 felgeilend lhdyakaidc yelagewyaq dqsvalsnkc fikcadlkal dgqyieasdi 181 ysklikssmg nrlsqwslkd yflkkglcql aatdavaaar tlqegqsedp nfadsresnf 241 lkslidavne gdseqlsehc kefdnfmrld kwkitilnki kesiqqqedd ll // LOCUS NP_009504 138 aa linear PLN 30-JUN-2025 DEFINITION Moh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009504 VERSION NP_009504.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178289.1 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 138) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07070. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..138 /product="Moh1p" /calculated_mol_wt="15954" Region 41..136 /region_name="RLR_C_like" /note="C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains; cl13152" /db_xref="CDD:472430" CDS 1..138 /gene="MOH1" /locus_tag="YBL049W" /coded_by="NM_001178289.1:1..417" /note="hypothetical protein, essential for stationary phase survival; not required for growth on nonfermentable carbon sources; possibly linked with vacuolar transport" /db_xref="GeneID:852231" /db_xref="SGD:S000000145" ORIGIN 1 mglrysiyie nplsspsssy ksindplfhs qhrsqknvsf itygcrhckt hlsssfqiis 61 rdyrgrtgta ylmnkvvnvv egkveqrrml tgdylvcdil chwckrnvgw kylqssnddq 121 qykegkfile lknickct // LOCUS NP_001335744 103 aa linear PLN 30-JUN-2025 DEFINITION Rrt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335744 VERSION NP_001335744.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348869.1 REFERENCE 1 (residues 1 to 103) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 103) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 103) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 103) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80264. Method: conceptual translation. FEATURES Location/Qualifiers source 1..103 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..103 /product="Rrt1p" /calculated_mol_wt="12316" CDS 1..103 /gene="RRT1" /locus_tag="YBL048W" /coded_by="NM_001348869.1:1..312" /note="hypothetical protein; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription" /db_xref="GeneID:852232" /db_xref="SGD:S000000144" ORIGIN 1 milfknlvfl psiligyisi rvsllvwvnw vlvwsscfqv afifslwyfi lsiytffysk 61 kikqiisyep syfvfsyrai dlcpervlly ffcifnnvvf pml // LOCUS NP_009506 1381 aa linear PLN 30-JUN-2025 DEFINITION Ede1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009506 VERSION NP_009506.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178287.1 REFERENCE 1 (residues 1 to 1381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1381) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07071. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1381 /product="Ede1p" /calculated_mol_wt="150653" Region 9..101 /region_name="EH" /note="Eps15 homology domain; smart00027" /db_xref="CDD:197477" Region 128..221 /region_name="EH" /note="Eps15 homology domain; smart00027" /db_xref="CDD:197477" Region 270..363 /region_name="EH" /note="Eps15 homology domain; smart00027" /db_xref="CDD:197477" Region <589..>879 /region_name="Smc" /note="Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; COG1196" /db_xref="CDD:440809" Region 713..1052 /region_name="COG4372" /note="Uncharacterized protein, contains DUF3084 domain [Function unknown]" /db_xref="CDD:443500" Region 1345..1379 /region_name="UBA_scEDE1_like" /note="UBA domain found in Saccharomyces cerevisiae EH domain-containing and endocytosis protein 1 (Ede1) and similar proteins; cd14285" /db_xref="CDD:270471" Site order(1348,1351..1354,1370..1372,1374..1375,1378) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270471" CDS 1..1381 /gene="EDE1" /locus_tag="YBL047C" /gene_synonym="BUD15" /coded_by="NM_001178287.1:1..4146" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25366307]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11452010]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11452010|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10954428|PMID:25366307]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:16563434]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0032467 positive regulation of cytokinesis [PMID:25371407]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:10954428]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16582425]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:25625208]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:25366307]" /note="Endocytic adaptor; K63-specific Ub-chain binding protein involved in receptor endocytosis; scaffold protein that localizes to nascent endocytic sites after homo-oligomerization and organizes the endocytic machinery; role in autophagy of aberrant clathrin-mediated endocytosis protein condensates; binds membranes in a Ub-dependent manner; interacts with and functions upstream of Cmk2p to suppress stress-induced non-apoptotic cell death; putative cytokinesis regulator; homolog of mammalian Eps15" /db_xref="GeneID:852233" /db_xref="SGD:S000000143" ORIGIN 1 masitfrtpl ssqeqafynq kfhqldtedl gvvtgeavrp lfassglpgq llsqvwatvd 61 idnkgflnln efsaalrmia qlqnapnqpi saalyestpt qlasfsinqn papmqsgsat 121 gntnntdipa lssndiakfs qlfdrtakga qtvagdkakd iflkarlpnq tlgeiwalcd 181 rdasgvldks efimamyliq lcmshhpsmn tppavlptql wdsirlepvv vnqpnrttpl 241 sanstgvssl trhstisrls tgafsnaasd wslsfekkqq fdaifdsldk qhagslssav 301 lvpfflssrl nqetlatiwd ladihnnaef tklefaiamf liqkknagve lpdvipnell 361 qspalglypp nplpqqqsap qiaipsrask pslqdmphqv sapavntqpt vpqvlpqnsn 421 ngslndllal npsfsspspt kaqtvvqnnt nnsfsydnnn gqatlqqqqp qqppplthss 481 sglkkftpts nfgqsiikee peeqeqlres sdtfsaqppp vpkhasspvk rtasttlpqv 541 pnfsvfsmpa gaatsaatga avgaavgaaa lgasafsrss nnafknqdlf adgeasaqls 601 nattemanls nqvnslskqa sitndkksra tqelkrvtem knsiqiklnn lrsthdqnvk 661 qteqleaqvl qvnkenetla qqlavseany haaesklnel ttdlqesqtk naelkeqitn 721 lnsmtaslqs qlnekqqqvk qersmvdvns kqlelnqvtv anlqkeidgl gekisvyltk 781 qkelndyqkt veeqhaqlqa kyqdlsnkdt dltdrekqle ernrqieeqe nlyhqhvskl 841 qemfddlsqr kasfekadqe lkernieyan nvrelserqm nlamgqlped akdiiaksas 901 ntdtttkeat srgnvhedtv skfvettven snlnvnrvkd deektertes dvfdrdvptl 961 gsqsdsenan tnngtqsgne tanpnltetl sdrfdgdlne ygiprsqslt ssvannapqs 1021 vrddvelpet leerdtinnt anrdntgnls hipgeweatp atastdvlsn etteviedgs 1081 ttkransned gesvssiqes pkisaqpkak tineefppiq elhidesdss ssdddefedt 1141 reipsatvkt lqtpynaqpt ssleihteqv ikypapgtsp shnegnskka stnsilpvkd 1201 efddefagle qaaveednga dsesefenva nagsmeqfet idhkdlddel qmnaftgtlt 1261 sssnptipkp qvqqqstsdp aqvsndewde ifagfgnska eptkvatpsi pqqpiplknd 1321 pivdaslskg pivnrgvatt pkslaveels gmgfteeeah nalekcnwdl eaatnfllds 1381 a // LOCUS NP_009507 441 aa linear PLN 30-JUN-2025 DEFINITION Psy4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009507 VERSION NP_009507.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178286.1 REFERENCE 1 (residues 1 to 441) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 441) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 441) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 441) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07072. Method: conceptual translation. FEATURES Location/Qualifiers source 1..441 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..441 /product="Psy4p" /calculated_mol_wt="50524" Region 5..253 /region_name="PPP4R2" /note="pfam09184" /db_xref="CDD:462710" CDS 1..441 /gene="PSY4" /locus_tag="YBL046W" /gene_synonym="HSM6" /coded_by="NM_001178286.1:1..1326" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16857015|PMID:14562095|PMID:19520826]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19520826]" /experiment="EXISTENCE:direct assay:GO:0030289 protein phosphatase 4 complex [PMID:17517611|PMID:16299494]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:16857015]" /experiment="EXISTENCE:mutant phenotype:GO:0030289 protein phosphatase 4 complex [PMID:16299494]" /experiment="EXISTENCE:mutant phenotype:GO:2000002 negative regulation of DNA damage checkpoint [PMID:16299494]" /note="Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2" /db_xref="GeneID:852234" /db_xref="SGD:S000000142" ORIGIN 1 msstmlddvd nnmmgiksis lyellsdvvk qgdktrlvta gpeqvlpdli rhitetipfd 61 lfinlknemn darnlvtrln wlgkflndnf lqnhtfpfti lricelcydp fkyykinele 121 kfvnalekcc mvtsswqvfd kthgekqedd kekdinfikn qedvslmkip wmtenntrel 181 apfireidsi msvnlgydde deeegffdgd edremgnksk rnvllkdenf mveeyyeddc 241 ginddnsdnk gqncqsdvtk nnsddedddd ndddyredga deddedddhm gstdddeddd 301 edrqagestk vqnfdkknet prkrkptdld nfeydespsf tnmdlttpkk ykhtatgrfs 361 iiespsssll namdgsneis ssqeeekeda henhegrseg llpgdelvsp smsssqedkm 421 vaiagityre nissplgkks r // LOCUS NP_009508 457 aa linear PLN 30-JUN-2025 DEFINITION ubiquinol--cytochrome-c reductase subunit COR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009508 VERSION NP_009508.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178285.1 REFERENCE 1 (residues 1 to 457) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 457) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 457) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 457) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07073. Method: conceptual translation. FEATURES Location/Qualifiers source 1..457 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..457 /product="ubiquinol--cytochrome-c reductase subunit COR1" /calculated_mol_wt="50097" Region 17..434 /region_name="PqqL" /note="Predicted Zn-dependent peptidase, M16 family [General function prediction only]; COG0612" /db_xref="CDD:440377" CDS 1..457 /gene="COR1" /locus_tag="YBL045C" /gene_synonym="QCR1" /coded_by="NM_001178285.1:1..1374" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0008121 quinol-cytochrome-c reductase activity [PMID:3023384]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:10873857|PMID:3023384]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:2174874]" /note="Core subunit of the ubiquinol-cytochrome c reductase complex; the ubiquinol-cytochrome c reductase complex (bc1 complex) is a component of the mitochondrial inner membrane electron transport chain" /db_xref="GeneID:852235" /db_xref="SGD:S000000141" ORIGIN 1 mlrtvtsktv snqfkrslat avatpkaevt qlsngivvat ehnpsahtas vgvvfgsgaa 61 nenpynngvs nlwkniflsk ensavaakeg lalssnisrd fqsyivsslp gstdksldfl 121 nqsfiqqkan llsssnfeat kksvlkqvqd feendhpnrv lehlhstafq ntplslptrg 181 tleslenlvv adlesfannh flnsnavvvg tgnikhedlv nsiesknlsl qtgtkpvlkk 241 kaaflgsevr lrddtlpkaw islavegepv nspnyfvakl aaqifgsyna fepasrlqgi 301 klldniqeyq lcdnfnhfsl sykdsglwgf statrnvtmi ddlihftlkq wnrltisvtd 361 teveraksll klqlgqlyes gnpvndanll gaevlikgsk lslgeafkki daitvkdvka 421 wagkrlwdqd iaiagtgqie glldymrirs dmsmmrw // LOCUS NP_009509 122 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL044W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009509 VERSION NP_009509.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178284.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 122) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07074. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..122 /product="uncharacterized protein" /calculated_mol_wt="13719" CDS 1..122 /locus_tag="YBL044W" /coded_by="NM_001178284.1:1..369" /note="hypothetical protein; YBL044W is not an essential protein" /db_xref="GeneID:852236" /db_xref="SGD:S000000140" ORIGIN 1 mgemlerqkk rlpskakylk ytasitetgn headssvifr phhsdvtcsn arraesrtlp 61 qicscilldh grrtrpevrt gmvslhgsfk gfpcfgirrg ishvlpgqkl rgscdnwkkr 121 qn // LOCUS NP_009510 257 aa linear PLN 30-JUN-2025 DEFINITION Ecm13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009510 VERSION NP_009510.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178283.1 REFERENCE 1 (residues 1 to 257) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 257) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 257) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 257) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07075. Method: conceptual translation. FEATURES Location/Qualifiers source 1..257 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..257 /product="Ecm13p" /calculated_mol_wt="28431" CDS 1..257 /gene="ECM13" /locus_tag="YBL043W" /coded_by="NM_001178283.1:1..774" /note="Non-essential hypothetical protein; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication" /db_xref="GeneID:852237" /db_xref="SGD:S000000139" ORIGIN 1 mnsttpsiqd qyilaskvrs klakcvsvtt knkdynlrvl vghanlldki tenvethnaa 61 tnalagdpfs kgpenlsieh ielsnanask ndvgkeenae ktiesedycd fyssdedpda 121 dtlsstdsed dddyedydfe ydysggdynk kidmyfsfht apnyqyltht nshseqtdel 181 aestprynal patastteee qdtetldavs lhssapifrv lsrrvngqed dsenesssdv 241 ddgsvpltrf hscpita // LOCUS NP_009511 639 aa linear PLN 30-JUN-2025 DEFINITION uridine permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_009511 VERSION NP_009511.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178282.1 REFERENCE 1 (residues 1 to 639) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 639) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 639) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 639) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07076. Method: conceptual translation. FEATURES Location/Qualifiers source 1..639 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..639 /product="uridine permease" /calculated_mol_wt="72034" Region 112..593 /region_name="SLC-NCS1sbd_NRT1-like" /note="nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain; cd11482" /db_xref="CDD:271375" Site order(138,141,429,432..433) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271375" Site order(142,218,222,342..343,345,434,438) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:271375" CDS 1..639 /gene="FUI1" /locus_tag="YBL042C" /coded_by="NM_001178282.1:1..1920" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922|PMID:16854981]" /experiment="EXISTENCE:direct assay:GO:0015213 uridine transmembrane transporter activity [PMID:16854981]" /experiment="EXISTENCE:direct assay:GO:0015862 uridine transmembrane transport [PMID:16854981]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:10827169]" /experiment="EXISTENCE:mutant phenotype:GO:0015213 uridine transmembrane transporter activity [PMID:10827169]" /experiment="EXISTENCE:mutant phenotype:GO:0015862 uridine transmembrane transport [PMID:16854981|PMID:10827169]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:10827169]" /note="High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport; relative distribution to the vacuole increases upon DNA replication stress" /db_xref="GeneID:852238" /db_xref="SGD:S000000138" ORIGIN 1 mpvsdsgfdn ssktmkddti ptedyeeitk esemgdatki tskidanvie kkdtdsenni 61 tiaqddekvs wlqrvveffe vkndstdlad hkpenpirtf kdlqeslrst ylyntdlrpv 121 eakrrtwtwk qyiffwisgs fnvntwqisa tglqlglnww qtwiciwvgy tfvafflilg 181 skvgnnyhis fpissrvsfg iyfsiwivin rvvmacvwns tlayigsqcv qlmlkaifgt 241 nlntrikdti knpnltnfef mcfmvfwvac lpflwfppdk lrhifalksa itpfaafgfl 301 iwtlckakgh lalgslndng gaisktvlaw sviraimsal dnfstlilna pdftrfgkty 361 kssvysqlia lpvcyaiisl igilsvsaay tlygvnywsp ldilnryldn ytsgnragvf 421 lisfifafdq lganlsgnsi pagtdltall pkfinirrgs yicalislai cpwdllssss 481 kfttalaaya vflsaiagvi sadyfivrkg yvnifhcytd kpgsyymynk ygtnwravva 541 yifgiapnfa gflgsvgvsv pigamkvyyl nyfvgyllaa lsycilvyfy pikgipgdak 601 itdrkwleew veveefgter eafeeyggvs tgyekiryi // LOCUS NP_009512 241 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit beta 6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009512 VERSION NP_009512.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178281.1 REFERENCE 1 (residues 1 to 241) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 241) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 241) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 241) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07077. Method: conceptual translation. FEATURES Location/Qualifiers source 1..241 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..241 /product="proteasome core particle subunit beta 6" /calculated_mol_wt="26740" Region 21..241 /region_name="proteasome_beta_type_1" /note="proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03757" /db_xref="CDD:239726" Site order(29,45,47,61,160,214,217..218) /site_type="active" /db_xref="CDD:239726" Site order(47,50,52..57,77,79,94,107,110..111,113..114,117,120, 145,147,149..152,155,163..164,166..167,170..172,205, 212..215,218..219) /site_type="other" /note="beta subunit interaction site [polypeptide binding]" /db_xref="CDD:239726" CDS 1..241 /gene="PRE7" /locus_tag="YBL041W" /gene_synonym="PRS3" /coded_by="NM_001178281.1:1..726" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /note="Beta 6 subunit of the 20S proteasome" /db_xref="GeneID:852239" /db_xref="SGD:S000000137" ORIGIN 1 matiaseyss easntpiehq fnpygdnggt ilgiagedfa vlagdtrnit dysinsryep 61 kvfdcgdniv msangfaadg dalvkrfkns vkwyhfdhnd kklsinsaar niqhllygkr 121 ffpyyvhtii agldedgkga vysfdpvgsy ereqcragga aaslimpfld nqvnfknqye 181 pgtngkvkkp lkylsveevi klvrdsftsa terhiqvgdg leilivtkdg vrkefyelkr 241 d // LOCUS NP_009513 219 aa linear PLN 30-JUN-2025 DEFINITION Erd2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009513 VERSION NP_009513.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178280.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 219) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07078. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..219 /product="Erd2p" /calculated_mol_wt="25632" Region 1..219 /region_name="ERD2" /note="ER lumen protein retaining receptor [Intracellular trafficking and secretion]; COG5196" /db_xref="CDD:227523" CDS 1..219 /gene="ERD2" /locus_tag="YBL040C" /coded_by="NM_001178280.1:1..660" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:2194670]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:7929564|PMID:9405360]" /experiment="EXISTENCE:mutant phenotype:GO:0045015 HDEL sequence binding [PMID:2194670]" /note="HDEL receptor; an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins" /db_xref="GeneID:852240" /db_xref="SGD:S000000136" ORIGIN 1 mnpfrilgdl shltsilili hnikttryie gisfktqtly alvfitryld lltfhwvsly 61 nalmkiffiv stayivvllq gskrtntiay nemlmhdtfk iqhlligsal msvffhhkft 121 flelawsfsv wlesvailpq lymlskggkt rsltvhyifa mglyralyip nwiwrysted 181 kkldkiaffa gllqtllysd ffyiyytkvi rgkgfklpk // LOCUS NP_878045 59 aa linear PLN 30-JUN-2025 DEFINITION Min6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878045 VERSION NP_878045.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184527.1 REFERENCE 1 (residues 1 to 59) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 59) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 59) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 59) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07079. Method: conceptual translation. FEATURES Location/Qualifiers source 1..59 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..59 /product="Min6p" /calculated_mol_wt="6742" CDS 1..59 /gene="MIN6" /locus_tag="YBL039W-B" /gene_synonym="YBL039W-A" /coded_by="NM_001184527.1:1..180" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:26928762]" /note="Mitochondrial hypothetical protein; mCherry fusion protein localizes to the vacuole" /db_xref="GeneID:1466441" /db_xref="SGD:S000028517" ORIGIN 1 mgffnnnpvi effhritrkp stiamwvfag licsstfylm fmssptidfn skskkkndk // LOCUS NP_009514 579 aa linear PLN 30-JUN-2025 DEFINITION CTP synthase URA7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009514 VERSION NP_009514.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178279.1 REFERENCE 1 (residues 1 to 579) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 579) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 579) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 579) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07080. Method: conceptual translation. FEATURES Location/Qualifiers source 1..579 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..579 /product="CTP synthase URA7" /EC_number="6.3.4.2" /calculated_mol_wt="64579" Region 1..555 /region_name="PyrG" /note="CTP synthase; TIGR00337" /db_xref="CDD:273021" CDS 1..579 /gene="URA7" /locus_tag="YBL039C" /coded_by="NM_001178279.1:1..1740" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003883 CTP synthase activity [PMID:8075080]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006241 CTP biosynthetic process [PMID:8075080]" /experiment="EXISTENCE:direct assay:GO:0097268 cytoophidium [PMID:20713603]" /experiment="EXISTENCE:mutant phenotype:GO:0003883 CTP synthase activity [PMID:1753946]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:9668079]" /experiment="EXISTENCE:mutant phenotype:GO:0019856 pyrimidine nucleobase biosynthetic process [PMID:1753946]" /note="Major CTP synthase isozyme (see also URA8); catalyzes ATP-dependent transfer of amide nitrogen from glutamine to UTP, forming CTP, final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; targeted to vacuole via AP-3 pathway; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has paralog URA8 that arose from the whole genome duplication" /db_xref="GeneID:852241" /db_xref="SGD:S000000135" ORIGIN 1 mkyvvvsggv isgigkgvla sstgmlmktl glkvtsikid pymnidagtm splehgecfv 61 lddggetdld lgnyerylgv tltkdhnitt gkiyshviak erkgdylgkt vqivphltna 121 iqdwiervak ipvddtgmep dvciielggt vgdiesapfv ealrqfqfkv gkenfalihv 181 slvpvihgeq ktkptqaaik glrslglvpd miacrcsetl dkptidkiam fchvgpeqvv 241 nvhdvnstyh vplllleqkm idylharlkl deislteeek qrglellskw kattgnfdes 301 metvkialvg kytnlkdsyl svikalehss mkcrrkldik wveatdlepe aqesnktkfh 361 eawnmvstad gilipggfgv rgtegmvlaa rwarenhipf lgvclglqia tieftrsvlg 421 rkdshsaefy pdideknhvv vfmpeidket mggsmrlglr ptffqnetew sqikklygdv 481 sevherhrhr yeinpkmvde lennglifvg kddtgkrcei lelknhpyyi atqyhpeyts 541 kvldpskpfl glvaasagil qdviegkydl eagenkfnf // LOCUS NP_009515 232 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL16m MRPL16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009515 VERSION NP_009515.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178278.1 REFERENCE 1 (residues 1 to 232) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 232) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 232) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 232) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07081. Method: conceptual translation. FEATURES Location/Qualifiers source 1..232 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..232 /product="mitochondrial 54S ribosomal protein uL16m MRPL16" /calculated_mol_wt="26387" Region 42..174 /region_name="Ribosomal_L16_L10e" /note="L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with the 30S subunit; cl00353" /db_xref="CDD:469737" Site order(65,67..68,71,88..89,92,95,99,102,110..112,114,116, 120..121,128..132,146,166..167,170..171) /site_type="other" /note="23S rRNA interface [nucleotide binding]" /db_xref="CDD:238714" Site 81..82 /site_type="other" /note="5S rRNA interface [nucleotide binding]" /db_xref="CDD:238714" Site order(93..95,98..99) /site_type="other" /note="putative antibiotic binding site [chemical binding]" /db_xref="CDD:238714" Site order(102,107..108,110,152) /site_type="other" /note="L25 interface [polypeptide binding]" /db_xref="CDD:238714" Site order(126..127,130..131) /site_type="other" /note="L27 interface [polypeptide binding]" /db_xref="CDD:238714" CDS 1..232 /gene="MRPL16" /locus_tag="YBL038W" /gene_synonym="RML16; uL16m" /coded_by="NM_001178278.1:1..699" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978|PMID:7478995]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:7478995]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:7478995]" /note="Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L16 ribosomal protein; synthetic lethality with hac1 mutation suggests a possible role in synthesis of precursors for protein glycosylation" /db_xref="GeneID:852242" /db_xref="SGD:S000000134" ORIGIN 1 mfpyltrmnl sikmggltlk esspnaflnn ttiarrfkhe yaprfkivqk kqkgrvpvrt 61 ggsikgstlq fgkyglrlks egirisaqql keadnaimry vrplnnghlw rrlctnvavc 121 ikgnetrmgk gkggfdhwmv rvptgkilfe ingddlhekv areafrkagt klpgvyefvs 181 ldslvrvglh sfknpkddpv knfydenakk pskkylnilk sqepqyklfr gr // LOCUS NP_009516 1025 aa linear PLN 30-JUN-2025 DEFINITION Apl3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009516 VERSION NP_009516.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178277.1 REFERENCE 1 (residues 1 to 1025) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1025) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1025) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1025) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07082. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1025 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1025 /product="Apl3p" /calculated_mol_wt="114881" Region 38..649 /region_name="Adaptin_N" /note="Adaptin N terminal region; pfam01602" /db_xref="CDD:396262" Region 901..1018 /region_name="Alpha_adaptin_C" /note="Alpha adaptin AP2, C-terminal domain; pfam02296" /db_xref="CDD:426707" CDS 1..1025 /gene="APL3" /locus_tag="YBL037W" /coded_by="NM_001178277.1:1..3078" /experiment="EXISTENCE:curator inference:GO:0006886 intracellular protein transport [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:19458192]" /experiment="EXISTENCE:mutant phenotype:GO:0030122 AP-2 adaptor complex [PMID:10564262]" /note="Alpha-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport" /db_xref="GeneID:852243" /db_xref="SGD:S000000133" ORIGIN 1 mdrkktlins svsnnnstik glqlfiadlr saqqaqeqek riqseivkik qhfdaakkkq 61 gnhdrlggyq rkkyvaklay iyitsnttkl neilfgleqt vellkssifs ekfigymtle 121 llyersevva kvndevnyql mkdlsssddn fvmlalnfvg vvgeltnrla ynddittgvf 181 kilrsptssi ylkkksalsf lallksnhsi ltedlqrkql wiqrilslld dtenyrltla 241 tipliefiak yidpsyctrl lpqlteilyn cvvvgtsrss dnqfpleytf anmpnpwlit 301 kvvsllsili aspterdsgs llqtnnidne llnklrkcvs vaielgtrqa qdpmerivqn 361 tvlfslinfa skldpsdeai snsvtalcsl ltskeiniry ltldslvklc sssgkpaida 421 vryknldmif hllnterdss ivrkvvdlly tftdvenvki ivdgllqyil spknlaepqi 481 ksdiavkiai ltekyatdin wfviislqll sltsnttind deiwqrlcqi vvnnpslhri 541 tcerlvdylc kkqaseaiik aaafllgeys slitdrissa nlftlfaeky fsapnvakam 601 ilttmiklyk tspeigsnvi kffqlelnsl dielqtrsfe ylniiqlakv ngntdilqil 661 fepmppfnsk snpllkrlgs lpasagsttl intpseasss tpdllskran ssrsimvpmp 721 ppsrrntidd vnskisssed fsgkdsyysr qilapnwreg ftrmishkqg vlftsslmkv 781 fyrittpdaq qpyvfhisla finlteweit glstqiipsk tqgnpeylim nintpstati 841 gphkraeqsy evsirkpfdv edspilaihf kcggstntin lktaigmttt lissdvnpsm 901 hlnlaqfisr wktlsdalgk egeyqksgik lnkdfrkvet isledgllll tqtvkrlgfd 961 ivdqtsvrst lfvsgiihtk segnfgclmk iqyqvngtvn vtcktttagp lakyivecik 1021 nvltk // LOCUS NP_009517 257 aa linear PLN 30-JUN-2025 DEFINITION pyridoxal phosphate homeostasis protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009517 VERSION NP_009517.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178276.1 REFERENCE 1 (residues 1 to 257) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 257) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 257) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 257) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07083. Method: conceptual translation. FEATURES Location/Qualifiers source 1..257 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..257 /product="pyridoxal phosphate homeostasis protein" /calculated_mol_wt="28992" Region 1..248 /region_name="TIGR00044" /note="pyridoxal phosphate enzyme, YggS family" /db_xref="CDD:129155" Site order(47,49,70,91,181,183,223..224,239..242) /site_type="other" /note="pyridoxal 5'-phosphate (PLP) binding site [chemical binding]" /db_xref="CDD:143496" Site 49 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:143496" CDS 1..257 /locus_tag="YBL036C" /coded_by="NM_001178276.1:1..774" /experiment="EXISTENCE:direct assay:GO:0030170 pyridoxal phosphate binding [PMID:12499548]" /experiment="EXISTENCE:mutant phenotype:GO:0042816 vitamin B6 metabolic process [PMID:37451483]" /note="Putative non-specific single-domain racemase; based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:852244" /db_xref="SGD:S000000132" ORIGIN 1 mstgityded rktqliaqye svrevvnaea knvhvnenas killlvvskl kpasdiqily 61 dhgvrefgen yvqeliekak llpddikwhf igglqtnkck dlakvpnlys vetidslkka 121 kklnesrakf qpdcnpilcn vqintshedq ksglnneaei fevidfflse eckyiklngl 181 mtigswnvsh edskenrdfa tlvewkkkid akfgtslkls mgmsadfrea irqgtaevri 241 gtdifgarpp knearii // LOCUS NP_009518 705 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed DNA polymerase alpha subunit POL12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009518 VERSION NP_009518.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178275.1 REFERENCE 1 (residues 1 to 705) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 705) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 705) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 705) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07084. Method: conceptual translation. FEATURES Location/Qualifiers source 1..705 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..705 /product="DNA-directed DNA polymerase alpha subunit POL12" /calculated_mol_wt="78643" Region 9..705 /region_name="POL12" /note="DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]; COG5214" /db_xref="CDD:227539" CDS 1..705 /gene="POL12" /locus_tag="YBL035C" /coded_by="NM_001178275.1:1..2118" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:1704371|PMID:3888995]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8289832|PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005658 alpha DNA polymerase:primase complex [PMID:3888995|PMID:22593576]" /experiment="EXISTENCE:genetic interaction:GO:0016233 telomere capping [PMID:15132993]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:8289832]" /experiment="EXISTENCE:mutant phenotype:GO:0016233 telomere capping [PMID:15132993]" /experiment="EXISTENCE:physical interaction:GO:0016233 telomere capping [PMID:15132993]" /note="B subunit of DNA polymerase alpha-primase complex; required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation" /db_xref="GeneID:852245" /db_xref="SGD:S000000131" ORIGIN 1 msgsidvith fgpdadkpei italenltkl halsvedlyi kweqfsnqrr qthtdltskn 61 idefkqflql qmekranqis ssskvntstk kpvikkslns splfglsipk tptlkkrklh 121 gpfslsdskq tynvgseaet nekgnsslkl eftpgmaeda vgdsaplsha kssdaktpgs 181 stfqtpttnt pttsrqnvpa geildslnpe nieissgnpn vgllsteeps ynqvkvepfy 241 dakkykfrtm rqnlqeasdv lddqiesftk iiqnhyklsp ndfadptiqs qseiyavgri 301 vpdsptydkf lnpeslslet srmggvgrrv rldlsqvnel sfflgqivaf kgknangdyf 361 tvnsilplpy pnspvstsqe lqefqanleg sslkvivtcg pyfandnfsl ellqefidsi 421 nnevkphvli mfgpfidith pliasgklpn fpqfktqpkt ldelflklft pilktisphi 481 qtvlipstkd aisnhaaypq aslirkalql pkrnfkcman pssfqineiy fgcsnvdtfk 541 dlkevikggt tssryrldrv sehilqqrry ypifpgsirt rikpkdvstk ketndmeske 601 ekvyehisga dldvsylglt efvggfspdi miipselqhf arvvqnvvvi npgrfiratg 661 nrgsyaqitv qcpdledgkl tlvegeepvy lhnvwkrarv dlias // LOCUS NP_009519 1513 aa linear PLN 30-JUN-2025 DEFINITION Stu1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009519 VERSION NP_009519.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178274.1 REFERENCE 1 (residues 1 to 1513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1513) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07085. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1513 /product="Stu1p" /calculated_mol_wt="174047" Region 318..560 /region_name="CLASP_N" /note="CLASP N terminal; pfam12348" /db_xref="CDD:432496" CDS 1..1513 /gene="STU1" /locus_tag="YBL034C" /coded_by="NM_001178274.1:1..4542" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:19952112]" /experiment="EXISTENCE:direct assay:GO:0005827 polar microtubule [PMID:19952112]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:12058056]" /experiment="EXISTENCE:direct assay:GO:0043515 kinetochore binding [PMID:19952112]" /experiment="EXISTENCE:direct assay:GO:0048487 beta-tubulin binding [PMID:12058056]" /experiment="EXISTENCE:direct assay:GO:0072686 mitotic spindle [PMID:19952112|PMID:7806575]" /experiment="EXISTENCE:direct assay:GO:1990023 mitotic spindle midzone [PMID:19952112]" /experiment="EXISTENCE:mutant phenotype:GO:0008017 microtubule binding [PMID:12058056]" /experiment="EXISTENCE:mutant phenotype:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:19952112]" /experiment="EXISTENCE:mutant phenotype:GO:0048487 beta-tubulin binding [PMID:12058056]" /experiment="EXISTENCE:mutant phenotype:GO:0090307 mitotic spindle assembly [PMID:7806575]" /note="Microtubule plus-end-tracking non-motor protein; binds to MTs, stabilizing interpolar MT plus ends, facilitating polymerization of spindle MTs and producing an outward force on spindle poles; required for structural integrity of the mitotic spindle; binds detached kinetochores (KTs) and promotes capture; relocalizes to MTs and stabilizes the spindle once captured KTs reach a spindle pole; localizes to the spindle, spindles poles, and detached KTs; CLASP family member homologous to human CLASP1/2" /db_xref="GeneID:852246" /db_xref="SGD:S000000130" ORIGIN 1 mssfnnetnn nsntnthpdd sfplytvfkd esvpieekma lltrfkghvk kelvnessiq 61 ayfaallfis ghyayrsypr liflshsslc ylikrvamqs pvqfndtlve qllnhlifel 121 pnekkfwlas ikaieaiylv npskiqaila nflrrpsenq ngdylnriks tlltideliq 181 ineknnsnhl qllrffmlsf tnllnnnlne handdnnnvi ielifdimyk ylkmddensq 241 dlidgfindl evekfkqkfi slaksqdqhg sqedkstlfd eeyefqllla eaklpqlsnn 301 lsskdpamkk nyeslnqlqq dlenllapfq svketeqnwk lrqsniield niisgnipkd 361 npeefvtvik evqlielisr atsslrttls ltallflkrl ihilndqlpl sildqifvif 421 knllsstkki ssqtafhcli tliidinhfh nklfqlsfll inektvtprf csaillrsfl 481 ikfndsnlsl nnsnttspts klenniiyie ewlkkgisds qttvreamrl tfwyfykcyp 541 tnakrllsss fspqlkkate laipahlnin yqvsrvssta sassatsrly shssnnssrk 601 tslleqkrny psyaqptqss stsllnapav taggsviask lsnklktnlr stseyssken 661 ekrarhhdsm nsvsnsntkd nnnvtkrkvs appsstaatk vsenytnfdd fpsnqidltd 721 elsnsysnpl ikkymdkndv smssspislk gsnklgeyet lykkfndasf paqikdalqy 781 lqkellltsq qsssapkfef pmimkklrqi mikspndfkp flsiekftng vplnyliely 841 sinsfdyaei lknrmnpekp yeltnliiti adlfnflnan ncpndfklyy mkykttffny 901 nfkllleifr nlnikhdntl rsgtndlmpk ismilfqiyg kefdytcyfn lifeiykfdn 961 nrfnklladf divstkmkic helekkdanf kvediisres svsftpidnk ksegdeesdd 1021 avdendvkkc memtminpfk nletdktlel knnvgkrtss tdsvvihddn dkdkklsemt 1081 kivsvyqldq pnpakeeddi dmensqksdl nlseifqnsg enterklkdd neptvkfstd 1141 ppkiinepek ligngnenek pdletmspik ingdenmgqk qritvkrerd valteqdins 1201 kkmklvnnkk sekmhllimd nfprdsltvy eishllmvds ngntlmdfdv yfnhmskain 1261 riksgsftmk hinyliepli tcfqnqkmtd wltnengfde lldvaimllk stddtpsips 1321 kissksiilv hcllvwkkfl ntlsenaddd gvsvrmcfee vweqillmln kfsdygneiy 1381 klaqefrdsl mlshffkkhs atrilsmlvt eiqpdtagvk etflietlwk mlqspticqq 1441 fkksniseii qtmsyfimgt dntswnftsa vvlarclrvl qttpdyteqe terlfdclpk 1501 nvfkmimfia sne // LOCUS NP_009520 345 aa linear PLN 30-JUN-2025 DEFINITION GTP cyclohydrolase II [Saccharomyces cerevisiae S288C]. ACCESSION NP_009520 VERSION NP_009520.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178273.1 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 345) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07086. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..345 /product="GTP cyclohydrolase II" /EC_number="3.5.4.25" /calculated_mol_wt="38201" Site order(37..43,52,54..56,63,65,67,147,149..150,152..156,158, 165..166,169,193,195,203..204,207..208,210..211,214) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:238348" Region 85..309 /region_name="ribA" /note="GTP cyclohydrolase II; TIGR00505" /db_xref="CDD:129596" Site order(143..148,150,159,161,164,196..199,206,210,213,219, 231,233,254..256,259) /site_type="active" /db_xref="CDD:238348" CDS 1..345 /gene="RIB1" /locus_tag="YBL033C" /coded_by="NM_001178273.1:1..1038" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0009231 riboflavin biosynthetic process [PMID:5366000|PMID:4555411]" /experiment="EXISTENCE:mutant phenotype:GO:0019238 cyclohydrolase activity [PMID:4555411]" /note="GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway" /db_xref="GeneID:852247" /db_xref="SGD:S000000129" ORIGIN 1 mtidnydnsk qdsskyevsg tgdgrngdgg lplvqcvara ripttqgpdi flhlysnnrd 61 nkehlaivfg edirsrslfr rrqcetqqdr mirgayigkl ypgrtvaded drlglalefd 121 dstgellask attwdahndt lvrihsecyt genawsarcd cgeqfdragr liacdhepts 181 nikggnghgv ivylrqegrg iglgeklkay nlqdlgadtv qanlmlkhpv dardfslgka 241 illdlgignv rlltnnpeki kqvdhapylk cvervpmvpi hwtnssegid skeiegylrt 301 kiermghllt eplklhtnpq ptetseaqnq nrmnsalsst stlai // LOCUS NP_009521 381 aa linear PLN 30-JUN-2025 DEFINITION Hek2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009521 VERSION NP_009521.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178272.1 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 381) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07087. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..381 /product="Hek2p" /calculated_mol_wt="41552" Region 44..113 /region_name="KH-I_Rnc1_rpt1" /note="first type I K homology (KH) RNA-binding domain found in Schizosaccharomyces pombe RNA-binding protein Rnc1 and similar proteins; cd22455" /db_xref="CDD:411883" Site order(53,55..57,59..63,66..67,70..71,76..79) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:411883" Region 158..226 /region_name="KH-I_Rnc1_rpt2" /note="second type I K homology (KH) RNA-binding domain found in Schizosaccharomyces pombe RNA-binding protein Rnc1 and similar proteins; cd22456" /db_xref="CDD:411884" Site order(166,168..170,172..176,179..180,183..184,189..192) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:411884" Region 257..330 /region_name="KH" /note="K homology RNA-binding domain; smart00322" /db_xref="CDD:197652" CDS 1..381 /gene="HEK2" /locus_tag="YBL032W" /gene_synonym="KHD1" /coded_by="NM_001178272.1:1..1146" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:11739741]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:20953064|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640|PMID:11867544]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11867544]" /experiment="EXISTENCE:direct assay:GO:0008298 intracellular mRNA localization [PMID:11867544]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:11739741]" /experiment="EXISTENCE:genetic interaction:GO:0048255 mRNA stabilization [PMID:20953064]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:11739741]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:11867544]" /experiment="EXISTENCE:mutant phenotype:GO:0048255 mRNA stabilization [PMID:20953064]" /note="RNA binding protein involved in asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K; increases mRNA stability by binding (CNN)n repeat elements" /db_xref="GeneID:852248" /db_xref="SGD:S000000128" ORIGIN 1 msqffeaatp vaiptnntng gssdagsaat ggapvvgtta qptinhrlll slkeaakiig 61 tkgstisrir aanavkigis ekvpgcsdri lscagnvinv anaigdivdv lnkrnpened 121 aaegeaeehy yfhflnhilp apskdeirdl qqledigyvr livanshiss iigkagatik 181 slinkhgvki vaskdflpas deriieiqgf pgsitnvlie iseiilsdvd vrfstersyf 241 phlkkssgep tspstssntr ielkipelyv gaiigrgmnr iknlktftkt nivverkddd 301 dkdenfrkfi itskfpknvk laesmllknl nteiekreny krkleaaegd atvvtersds 361 asfleekeep qenhdnkeeq s // LOCUS NP_009522 338 aa linear PLN 30-JUN-2025 DEFINITION She1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009522 VERSION NP_009522.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178271.1 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 338) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07088. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..338 /product="She1p" /calculated_mol_wt="37884" Region 34..328 /region_name="Msap1" /note="Mitotic spindle associated protein SHE1; pfam17077" /db_xref="CDD:293682" CDS 1..338 /gene="SHE1" /locus_tag="YBL031W" /coded_by="NM_001178271.1:1..1017" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:17634282]" /experiment="EXISTENCE:direct assay:GO:0005880 nuclear microtubule [PMID:17634282]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17634282]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:23142046]" /experiment="EXISTENCE:direct assay:GO:0015630 microtubule cytoskeleton [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:18194531]" /experiment="EXISTENCE:mutant phenotype:GO:0040001 establishment of mitotic spindle localization [PMID:34854468]" /note="Mitotic spindle-associated protein; microtubule-associate protein (MAP) that inhibits dynein motility along microtubules, acting directly on the motor domain, independent of the dynactin complex; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and MAP Bim1p; localizes to nuclear microtubules, the mitotic spindle and to the bud neck in a ring-shaped structure" /db_xref="GeneID:852249" /db_xref="SGD:S000000127" ORIGIN 1 mndklqeehn ekdttsqing ftpphmsidf hsnnnsniie tigvskrlgn svlseldsra 61 sskfeflkdq seqqyngdkn nepksgsyni neffqakhds qfgqmesldt hytllhtpkr 121 ksqhaipqdr sdsmkrsrps rsipyttpvv nditrrirrl klrnslvngn divararsmq 181 ansninsikn tplskpkpfm hkpnflmptt nslnkinsah rntsssstas siprskvhrs 241 isirdlhakt kpvertpvaq gtnsqlknsv svfdrlykqt tfsrstsmnn lssgtsaksk 301 ehtnvktrlv ksktsgslss nlkqstatgt ksdrpiwr // LOCUS NP_009523 318 aa linear PLN 30-JUN-2025 DEFINITION ADP/ATP carrier protein PET9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009523 VERSION NP_009523.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178270.1 REFERENCE 1 (residues 1 to 318) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 318) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 318) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 318) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07089. Method: conceptual translation. FEATURES Location/Qualifiers source 1..318 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..318 /product="ADP/ATP carrier protein PET9" /calculated_mol_wt="34295" Region 22..312 /region_name="PTZ00169" /note="ADP/ATP transporter on adenylate translocase; Provisional" /db_xref="CDD:240302" CDS 1..318 /gene="PET9" /locus_tag="YBL030C" /gene_synonym="AAC2; ANC2" /coded_by="NM_001178270.1:1..957" /experiment="EXISTENCE:direct assay:GO:0005471 ATP:ADP antiporter activity [PMID:8476415]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:795470]" /experiment="EXISTENCE:direct assay:GO:0015866 ADP transport [PMID:8476415]" /experiment="EXISTENCE:direct assay:GO:0015867 ATP transport [PMID:8476415]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:8476415]" /experiment="EXISTENCE:genetic interaction:GO:0009061 anaerobic respiration [PMID:1915842]" /experiment="EXISTENCE:genetic interaction:GO:0015867 ATP transport [PMID:35127709]" /experiment="EXISTENCE:mutant phenotype:GO:0006839 mitochondrial transport [PMID:2167309]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17822411]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:2167309]" /experiment="EXISTENCE:mutant phenotype:GO:0015886 heme transport [PMID:18728780]" /experiment="EXISTENCE:mutant phenotype:GO:1901612 cardiolipin binding [PMID:38839991]" /note="Major ADP/ATP carrier of the mitochondrial inner membrane; exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; also functions in peroxisomes; required for viability in many lab strains that carry a sal1 mutation; PET9 has a paralog, AAC3, that arose from the whole genome duplication; human homolog SLC25A4 implicated in progressive external ophthalmoplegia can complement yeast null mutant" /db_xref="GeneID:852250" /db_xref="SGD:S000000126" ORIGIN 1 mssnaqvktp lppapapkke snflidflmg gvsaavakta aspiervkll iqnqdemlkq 61 gtldrkyagi ldcfkrtatq egvisfwrgn tanviryfpt qalnfafkdk ikamfgfkke 121 egyakwfagn lasggaagal sllfvysldy artrlaadsk sskkggarqf nglidvykkt 181 lksdgvagly rgflpsvvgi vvyrglyfgm ydslkplllt gslegsflas fllgwvvttg 241 astcsypldt vrrrmmmtsg qavkydgafd clrkivaaeg vgslfkgcga nilrgvagag 301 vismydqlqm ilfgkkfk // LOCUS NP_076874 94 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL029C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_076874 VERSION NP_076874.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184457.1 REFERENCE 1 (residues 1 to 94) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 94) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 94) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 94) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07090. Method: conceptual translation. FEATURES Location/Qualifiers source 1..94 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..94 /product="uncharacterized protein" /calculated_mol_wt="11030" CDS 1..94 /locus_tag="YBL029C-A" /coded_by="NM_001184457.1:1..285" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica" /db_xref="GeneID:852251" /db_xref="SGD:S000007591" ORIGIN 1 msfipivcgm ksfdssydtv pghqnlycpn chnysvgpik rkefftiwfi plvpvfwgkq 61 lhcpicnwrq dfkndeqlnk viqeqqnlrq kqpn // LOCUS NP_009524 376 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL029W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009524 VERSION NP_009524.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178269.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 376) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07091. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..376 /product="uncharacterized protein" /calculated_mol_wt="42473" CDS 1..376 /locus_tag="YBL029W" /coded_by="NM_001178269.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Non-essential hypothetical protein" /db_xref="GeneID:852252" /db_xref="SGD:S000000125" ORIGIN 1 mcanipefds fyeneninyn lesfaplncd vnspflpinn ndinvnaygd enltysnfll 61 syndklattt aknnsinnsn snnnsnnnkn nnnnhnnnnl lgndisqmaf lldypstlne 121 pqfavnckdi yrkdistpss lvsslppakf slslsnspsp pppsssslkh geaiisntse 181 ssdifadpns fekdtmpltq eltlenlnnq lnypdftina ieqdpapssf sssssssest 241 vsssrkrkpc hdsythssps sseskkisds rlsaeglakv lnlespeeal krerfilgif 301 qnelnyplgy ktwirdttke yrtklinqlh ervkvkypey nqsiletiir rgtyymmqsr 361 lrrerrmklk erkrtt // LOCUS NP_009525 106 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL028C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009525 VERSION NP_009525.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178268.1 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 106) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07092. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..106 /product="uncharacterized protein" /calculated_mol_wt="12270" Region 1..44 /region_name="DUF2423" /note="Protein of unknown function (DUF2423); pfam10338" /db_xref="CDD:431219" CDS 1..106 /locus_tag="YBL028C" /coded_by="NM_001178268.1:1..321" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350]" /note="hypothetical protein that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis" /db_xref="GeneID:852253" /db_xref="SGD:S000000124" ORIGIN 1 makslrassh lnaksvkrrg vfqkavdare qrisdklked llkqkledlk kkeeqgidmd 61 vdekksneea prkkistsgw rdgrhhtykk aklmkqskkk tsftrf // LOCUS NP_009526 189 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL19 RPL19B [Saccharomyces cerevisiae S288C]. ACCESSION NP_009526 VERSION NP_009526.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178267.1 REFERENCE 1 (residues 1 to 189) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 189) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 189) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 189) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07093. Method: conceptual translation. FEATURES Location/Qualifiers source 1..189 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..189 /product="60S ribosomal protein eL19 RPL19B" /calculated_mol_wt="21573" Region 4..166 /region_name="Ribosomal_L19e_E" /note="Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an...; cd01417" /db_xref="CDD:238705" Site order(4,8..9,18..24,26,29,38,42,53,55..60,62,64,66..67, 69..70,72,74..79,81..89,92,95..97,100..101,103,110, 117..118,120..121,124..126,129,131,134..135) /site_type="other" /note="protein-rRNA interface [nucleotide binding]" /db_xref="CDD:238705" Site 28..47 /site_type="active" /note="putative translocon docking site [active]" /db_xref="CDD:238705" Site order(112..113,115..119,139..149) /site_type="active" /note="putative intersubunit bridge [active]" /db_xref="CDD:238705" CDS 1..189 /gene="RPL19B" /locus_tag="YBL027W" /coded_by="NM_001178267.1:1..570" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L19B; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19B has a paralog, RPL19A, that arose from the whole genome duplication" /db_xref="GeneID:852254" /db_xref="SGD:S000000123" ORIGIN 1 manlrtqkrl aasvvgvgkr kvwldpnets eiaqansrna irklvkngti vkkavtvhsk 61 srtrahaqsk regrhsgygk rkgtrearlp sqvvwirrlr vlrrllakyr dagkidkhly 121 hvlykeskgn afkhkralve hiiqakadaq rekalneeae arrlknraar drraqrvaek 181 rdallkeda // LOCUS NP_009527 95 aa linear PLN 30-JUN-2025 DEFINITION Sm-like protein LSM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009527 VERSION NP_009527.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178266.1 REFERENCE 1 (residues 1 to 95) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 95) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 95) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 95) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07094. Method: conceptual translation. FEATURES Location/Qualifiers source 1..95 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..95 /product="Sm-like protein LSM2" /calculated_mol_wt="11032" Region 2..90 /region_name="LSm2" /note="Like-Sm protein 2; cd01725" /db_xref="CDD:212472" Site order(7,10..11,16,18..20,23,25,30..33,36..37,39,59..71) /site_type="other" /note="putative oligomer interface [polypeptide binding]" /db_xref="CDD:212472" Site order(15..21,23..35,37..41) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212472" Site order(33,35,63) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:212472" Site 59..70 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212472" CDS 1..95 /gene="LSM2" /locus_tag="YBL026W" /gene_synonym="SMX5; SNP3" /coded_by="NM_001178266.1:1..288" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:10377396]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:18611963]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:15075370]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:11720284|PMID:10369684]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15075370]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970]" /experiment="EXISTENCE:physical interaction:GO:0005732 sno(s)RNA-containing ribonucleoprotein complex [PMID:15075370]" /note="Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:852255" /db_xref="SGD:S000000122" ORIGIN 1 mlffsffktl vdqevvvelk ndieikgtlq svdqflnlkl dnisctdekk yphlgsvrni 61 firgstvryv ylnknmvdtn llqdatrrev mterk // LOCUS NP_009528 145 aa linear PLN 30-JUN-2025 DEFINITION Rrn10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009528 VERSION NP_009528.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178265.1 REFERENCE 1 (residues 1 to 145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 145) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07095. Method: conceptual translation. FEATURES Location/Qualifiers source 1..145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..145 /product="Rrn10p" /calculated_mol_wt="16374" Region 1..120 /region_name="UAF_Rrn10" /note="UAF complex subunit Rrn10; pfam05234" /db_xref="CDD:113985" CDS 1..145 /gene="RRN10" /locus_tag="YBL025W" /coded_by="NM_001178265.1:1..438" /experiment="EXISTENCE:direct assay:GO:0000500 RNA polymerase I upstream activating factor complex [PMID:8846924]" /experiment="EXISTENCE:direct assay:GO:0001165 RNA polymerase I cis-regulatory region sequence-specific DNA binding [PMID:18451108]" /experiment="EXISTENCE:direct assay:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:8846924]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22362748]" /experiment="EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8846924]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8846924]" /note="Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I" /db_xref="GeneID:852256" /db_xref="SGD:S000000121" ORIGIN 1 mdrnvyeacs niikefgthv vsadevlaek idnavpipfk treeidadve kdrnegvfeg 61 niipdidlrv vhyyatqlcl nkyphlinaf detslitlgl liekwvkdyl tsiqteqgrq 121 skvigkgpce fiskhidyrh apgni // LOCUS NP_009529 684 aa linear PLN 30-JUN-2025 DEFINITION tRNA (cytosine-C5-)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009529 VERSION NP_009529.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178264.1 REFERENCE 1 (residues 1 to 684) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 684) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 684) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 684) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07096. Method: conceptual translation. FEATURES Location/Qualifiers source 1..684 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..684 /product="tRNA (cytosine-C5-)-methyltransferase" /EC_number="2.1.1.202" /calculated_mol_wt="77748" Region <44..412 /region_name="RsmB" /note="16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; COG0144" /db_xref="CDD:439914" CDS 1..684 /gene="NCL1" /locus_tag="YBL024W" /gene_synonym="TRM4" /coded_by="NM_001178264.1:1..2055" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:17567576]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9767141]" /experiment="EXISTENCE:direct assay:GO:0016428 tRNA (cytidine-5-)-methyltransferase activity [PMID:10445884]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:10445884]" /experiment="EXISTENCE:mutant phenotype:GO:0002127 tRNA wobble base cytosine methylation [PMID:22760636]" /experiment="EXISTENCE:mutant phenotype:GO:0070301 cellular response to hydrogen peroxide [PMID:22760636]" /note="S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase; methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; increases proportion of tRNALeu(CAA) with m5C at wobble position in response to hydrogen peroxide, causing selective translation of mRNA from genes enriched in TTG codon; loss of NCL1 confers hypersensitivity to oxidative stress; similar to Nop2p and human proliferation associated nucleolar protein p120" /db_xref="GeneID:852257" /db_xref="SGD:S000000120" ORIGIN 1 marrknfkkg nkktfgardd sraqknwsel vkenekweky yktlalfped qweefkktcq 61 aplpltfrit gsrkhagevl nlfkerhlpn ltnvefegek ikapvelpwy pdhlawqldv 121 pktvirkneq faktqrflvv enavgnisrq eavsmippiv levkphhtvl dmcaapgskt 181 aqliealhkd tdepsgfvva ndadarrshm lvhqlkrlns anlmvvnhda qffprirlhg 241 nsnnkndvlk fdrilcdvpc sgdgtmrknv nvwkdwntqa glglhavqln ilnrglhllk 301 nngrlvystc slnpieneav vaealrkwgd kirlvncddk lpglirskgv skwpvydrnl 361 tektkgdegt ldsffspsee easkfnlqnc mrvyphqqnt ggffitvfek vedsteaate 421 klssetpale segpqtkkik veevqkkerl prdaneepfv fvdpqhealk vcwdfygidn 481 ifdrntclvr natgeptrvv ytvcpalkdv iqanddrlki iysgvklfvs qrsdiecswr 541 iqseslpimk hhmksnrive anlemlkhll iesfpnfddi rsknidndfv ekmtklssgc 601 afidvsrndp akenlflpvw kgnkcinlmv ckedthelly rifgidanak atpsaeekek 661 ekettespae tttgtsteap saan // LOCUS NP_009530 868 aa linear PLN 30-JUN-2025 DEFINITION MCM DNA helicase complex subunit MCM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009530 VERSION NP_009530.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178263.1 REFERENCE 1 (residues 1 to 868) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 868) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 868) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 868) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07097. Method: conceptual translation. FEATURES Location/Qualifiers source 1..868 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..868 /product="MCM DNA helicase complex subunit MCM2" /EC_number="3.6.4.12" /calculated_mol_wt="98649" Region 49..193 /region_name="MCM2_N" /note="Mini-chromosome maintenance protein 2; pfam12619" /db_xref="CDD:403724" Region 209..299 /region_name="MCM_N" /note="MCM N-terminal domain; pfam14551" /db_xref="CDD:464206" Region 302..846 /region_name="MCM" /note="minichromosome maintenance proteins; smart00350" /db_xref="CDD:214631" Site order(505,546..551,608,676,695,807..808) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350659" Site order(525,530..531,544..546,562,578,583..585,588..592, 597..598,618,621..622,625..626,629..638,640..641,654..656, 686..687,689,692..693,695..696,699..700,702..706,778,780, 787,790,794..795,803,806..807,811,814) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:350659" Site order(574,579,581,633..634) /site_type="other" /note="nucleic acid binding site [nucleotide binding]" /db_xref="CDD:350659" CDS 1..868 /gene="MCM2" /locus_tag="YBL023C" /coded_by="NM_001178263.1:1..2607" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10783164]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194|PMID:11756674]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10704410|PMID:22842922|PMID:8224843]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8224843|PMID:22842922|PMID:10704410]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:18657510]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0042555 MCM complex [PMID:12480933]" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:17895243]" /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:10834843]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:22564307]" /experiment="EXISTENCE:mutant phenotype:GO:1902975 mitotic DNA replication initiation [PMID:9407029|PMID:8224843]" /note="Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; binds and transfers parental H3-H4 to Pol32p facilitating the transfer of parental histones to the lagging strand via Pol1p during DNA replication; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:852258" /db_xref="SGD:S000000119" ORIGIN 1 msdnrrrrre eddsdsenel ppsspqqhfr ggmnpvsspi gspdminpeg ddnevddvpd 61 ideveeqmne vdlmddnmye dyaadhnrdr ydpdqvddre qqelslserr ridaqlnerd 121 rllrnvayid dedeeqegaa qldemglpvq rrrrrrqyed lensdddlls dmdidplree 181 ltleslsnvk ansysewitq pnvsrtiare lksflleytd etgrsvygar irtlgemnse 241 slevnyrhla eskailalfl akcpeemlki fdlvameate lhypdyarih seihvrisdf 301 ptiyslrelr esnlsslvrv tgvvtrrtgv fpqlkyvkfn clkcgsilgp ffqdsneeir 361 isfctncksk gpfrvngekt vyrnyqrvtl qeapgtvppg rlprhrevil ladlvdvskp 421 geevevtgiy knnydgnlna kngfpvfati ieansikrre gntanegeeg ldvfswteee 481 erefrkisrd rgiidkiiss mapsiyghrd iktavacslf ggvpknvngk hsirgdinvl 541 llgdpgtaks qilkyvekta hravfatgqg asavgltasv rkdpitkewt leggalvlad 601 kgvclidefd kmndqdrtsi heameqqsis iskagivttl qarcsiiaaa npnggrynst 661 lplaqnvslt epilsrfdil cvvrdlvdee aderlatfvv dshvrshpen dedregeelk 721 nngesaieqg edeineqlna rqrrlqrqrk keeeispipq ellmkyihya rtkiypklhq 781 mdmdkvsrvy adlrresist gsfpitvrhl esilriaesf akmrlsefvs sydldraikv 841 vvdsfvdaqk vsvrrqlrrs faiytlgh // LOCUS NP_009531 1133 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent Lon protease PIM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009531 VERSION NP_009531.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178262.1 REFERENCE 1 (residues 1 to 1133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1133) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07098. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1133 /product="ATP-dependent Lon protease PIM1" /EC_number="3.4.21.53" /calculated_mol_wt="126981" Region 183..1107 /region_name="lon" /note="endopeptidase La; TIGR00763" /db_xref="CDD:273258" CDS 1..1133 /gene="PIM1" /locus_tag="YBL022C" /coded_by="NM_001178262.1:1..3402" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:genetic interaction:GO:0051131 chaperone-mediated protein complex assembly [PMID:8810243]" /experiment="EXISTENCE:genetic interaction:GO:0141164 mitochondrial protein quality control [PMID:7957078]" /experiment="EXISTENCE:mutant phenotype:GO:0004176 ATP-dependent peptidase activity [PMID:8276800|PMID:8146662]" /experiment="EXISTENCE:mutant phenotype:GO:0005759 mitochondrial matrix [PMID:8146662|PMID:8276800]" /experiment="EXISTENCE:mutant phenotype:GO:0141164 mitochondrial protein quality control [PMID:7957078|PMID:16336126]" /experiment="EXISTENCE:mutant phenotype:GO:1901858 regulation of mitochondrial DNA metabolic process [PMID:31532710]" /note="ATP-dependent Lon protease; involved in degradation of misfolded mitochondrial proteins; required for mitochondrial maintenance and biogenesis; regulates mitochondrial DNA copy number with Mrx6p; subunit of a complex containing Mrx6p, Pet20p, and Mam33p that may regulate mtDNA replication; protease-independent, chaperone-like function in mitochondrial membrane complex assembly; localizes to the mitochondrial matrix" /db_xref="GeneID:852259" /db_xref="SGD:S000000118" ORIGIN 1 mlrtrttktl stvarttrai qyyrsiakta avsqrrfast ltvrdvenik pshiiksptw 61 qefqhqlkdp rymehfaqld aqfarhfmat nsgksilakd dstsqkkded vkivpdekdt 121 dndveptrdd eivnkdqege asknsrssas gggqssssrs dsgdgsskqk ppkdvpevyp 181 qmlalpiarr plfpgfykav visdervmka ikemldrqqp yigafmlkns eedtdvitdk 241 ndvydvgvla qitsafpskd ektgtetmta llyphrriki delfppneek ekskeqakdt 301 dtettvveda nnpedqests patpklediv veripdselq hhkrveatee eseelddiqe 361 gedinptefl knynvslvnv lnledepfdr kspvinalts eilkvfkeis qlntmfreqi 421 atfsasiqsa ttnifeepar ladfaaavsa geedelqdil sslniehrle ksllvlkkel 481 mnaelqnkis kdvetkiqkr qreyylmeql kgikrelgid dgrdklidty kerikslklp 541 dsvqkifdde itklstlets msefgvirny ldwltsipwg khskeqysip rakkildedh 601 ygmvdvkdri lefiavgkll gkvdgkiicf vgppgvgkts igksiaraln rkffrfsvgg 661 mtdvaeikgh rrtyigalpg rvvqalkkcq tqnplilide idkighggih gdpsaallev 721 ldpeqnnsfl dnyldipidl skvlfvctan sletiprpll drmevieltg yvaedkvkia 781 eqylvpsakk saglenshvd mtedaitalm kyycresgvr nlkkhiekiy rkaalqvvkk 841 lsiedsptss adskpkesvs seekaennak sssektkdnn sektsddiea lktsekinvs 901 isqknlkdyv gppvyttdrl yettppgvvm glawtnmggc slyvesvleq plhnckhptf 961 ertgqlgdvm kessrlaysf akmylaqkfp enrffekasi hlhcpegatp kdgpsagvtm 1021 atsflslaln ksidptvamt geltltgkvl rigglrekav aakrsgakti ifpkdnlndw 1081 eelpdnvkeg leplaadwyn difqklfkdv ntkegnsvwk aefeildakk ekd // LOCUS NP_009532 144 aa linear PLN 30-JUN-2025 DEFINITION Hap3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009532 VERSION NP_009532.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178261.1 REFERENCE 1 (residues 1 to 144) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 144) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 144) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 144) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07099. Method: conceptual translation. FEATURES Location/Qualifiers source 1..144 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..144 /product="Hap3p" /calculated_mol_wt="16023" Region 35..125 /region_name="HFD_NFYB" /note="histone-fold domain found in nuclear transcription factor Y subunit beta (NF-YB) and similar proteins; cd22907" /db_xref="CDD:467032" Site order(35,37..38,41,67,70..71,75,78..79,82..83,86,106..108, 110) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:467032" Site order(38..43,46,50..51,54..56,59..62,65,68..69,72..77, 79..82,85,94..98,101,105,109..110,113,117,120,124..125) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467032" Site order(38,43..46,49,52,60..63,66,94..95) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:467032" CDS 1..144 /gene="HAP3" /locus_tag="YBL021C" /coded_by="NM_001178261.1:1..435" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:7828851]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:2832951]" /experiment="EXISTENCE:direct assay:GO:0016602 CCAAT-binding factor complex [PMID:2832951]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2832951]" /experiment="EXISTENCE:mutant phenotype:GO:0043457 regulation of cellular respiration [PMID:2182199]" /experiment="EXISTENCE:physical interaction:GO:0016602 CCAAT-binding factor complex [PMID:2832951]" /note="Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding" /db_xref="GeneID:852260" /db_xref="SGD:S000000117" ORIGIN 1 mntnesehvs tspedtqeng gnasssgslq qistlreqdr wlpinnvarl mkntlppsak 61 vskdakecmq ecvselisfv tseasdrcaa dkrktinged ilislhalgf enyaevlkiy 121 lakyrqqqal knqlmyeqdd eevp // LOCUS NP_009533 574 aa linear PLN 30-JUN-2025 DEFINITION glycolipid translocation protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009533 VERSION NP_009533.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178260.1 REFERENCE 1 (residues 1 to 574) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 574) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 574) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 574) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07100. Method: conceptual translation. FEATURES Location/Qualifiers source 1..574 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..574 /product="glycolipid translocation protein" /calculated_mol_wt="66080" Region 18..563 /region_name="Rft-1" /note="Rft protein; pfam04506" /db_xref="CDD:427987" CDS 1..574 /gene="RFT1" /locus_tag="YBL020W" /coded_by="NM_001178260.1:1..1725" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0034202 glycolipid floppase activity [PMID:38886340]" /experiment="EXISTENCE:direct assay:GO:0034203 glycolipid translocation [PMID:38886340]" /experiment="EXISTENCE:genetic interaction:GO:0005789 endoplasmic reticulum membrane [PMID:11807558]" /experiment="EXISTENCE:genetic interaction:GO:0034203 glycolipid translocation [PMID:11807558|PMID:38886340]" /experiment="EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:11807558]" /experiment="EXISTENCE:mutant phenotype:GO:0034203 glycolipid translocation [PMID:11807558]" /note="ER membrane floppase required for the translocation of Man5GlcNac2-PP-Dol; catalyzes the translocation of the lipid-linked oligosaccharide Man5GlcNac2-PP-Dol across the ER lipid bilayer from the cytoplasmic face to the lumen; mutation is suppressed by expression of human p53 protein; human ortholog RFT1 complements the yeast null mutant" /db_xref="GeneID:852261" /db_xref="SGD:S000000116" ORIGIN 1 makknsqlps tseqilerst tgatflmmgq lftklvtfil nnllirflsp rifgitafle 61 fiqgtvlffs rdairlstlr isdsgngiid dddeeeyqet hykskvlqta vnfayipfwi 121 gfplsiglia wqyrninayf itlpffrwsi fliwlsiive llsepffivn qfmlnyaars 181 rfesiavttg civnfivvya vqqsrypmgv vtsdidkegi ailafalgkl ahsitllacy 241 ywdylknfkp kklfstrltk iktrennelk kgypkstsyf fqndilqhfk kvyfqlcfkh 301 lltegdklii nslctveeqg iyallsnygs lltrllfapi eeslrlflar llsshnpknl 361 klsievlvnl trfyiylslm iivfgpanss fllqfligsk wsttsvldti rvycfyipfl 421 slngifeaff qsvatgdqil khsyfmmafs gifllnswll ieklklsieg lilsniinmv 481 lrilycgvfl nkfhrelftd ssfffnfkdf ktviiagsti clldwwfigy vknlqqfvvn 541 vlfamgllal ilvkerqtiq sfinkravsn skdv // LOCUS NP_009534 520 aa linear PLN 30-JUN-2025 DEFINITION DNA-(apurinic or apyrimidinic site) lyase APN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009534 VERSION NP_009534.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178259.1 REFERENCE 1 (residues 1 to 520) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 520) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 520) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 520) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07101. Method: conceptual translation. FEATURES Location/Qualifiers source 1..520 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..520 /product="DNA-(apurinic or apyrimidinic site) lyase APN2" /EC_number="3.1.11.2" /calculated_mol_wt="59314" Region 18..361 /region_name="Ape2-like_AP-endo" /note="Human Ape2-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; cd09088" /db_xref="CDD:197322" Site order(23,25..30,59,61,65,88..89,165,181,184,186,192,222, 224,234,236,238,311,313..315,317,321,323,325,327..328,351, 353..354) /site_type="active" /note="putative active site [active]" /db_xref="CDD:197322" Site order(23,25..30,59,61,65,88..89,165,181,184,186,192,222, 224,234,236,238,311,313..315,321,323,325,327,351,354) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:197322" Site order(23,59,181,184,222,224,354) /site_type="other" /note="putative phosphate binding site [ion binding]" /db_xref="CDD:197322" Site order(23,59,181,222,224,328,353..354) /site_type="active" /note="putative catalytic site [active]" /db_xref="CDD:197322" Site order(25,59,353) /site_type="other" /note="putative metal binding site A [ion binding]" /db_xref="CDD:197322" Site order(181,184,222,224,311,325,327,354) /site_type="other" /note="putative AP binding site [nucleotide binding]" /db_xref="CDD:197322" Site order(222,224,354) /site_type="other" /note="putative metal binding site B [ion binding]" /db_xref="CDD:197322" Region 474..520 /region_name="zf-GRF" /note="GRF zinc finger; cl46396" /db_xref="CDD:480736" CDS 1..520 /gene="APN2" /locus_tag="YBL019W" /gene_synonym="ETH1" /coded_by="NM_001178259.1:1..1563" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10806210]" /experiment="EXISTENCE:direct assay:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:10806210]" /experiment="EXISTENCE:direct assay:GO:0008081 phosphoric diester hydrolase activity [PMID:11238902]" /experiment="EXISTENCE:direct assay:GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity [PMID:11238902]" /experiment="EXISTENCE:direct assay:GO:0008408 3'-5' exonuclease activity [PMID:30778235]" /experiment="EXISTENCE:genetic interaction:GO:0006284 base-excision repair [PMID:9765213]" /note="Class II abasic (AP) endonuclease involved in repair of DNA damage; also possesses 3'-diesterase and PCNA-stiimulated 3' to 5' exonuclease activities; resolves blocked 3' ends that result from removal of misincorporated nucleotides; frays and cleaves 3' DNA termini facilitating 3' DNA-end healing via endonucleolytic cleavage; homolog of human APEX2 and E. coli exoIII" /db_xref="GeneID:852262" /db_xref="SGD:S000000115" ORIGIN 1 msssentlld gksentirfl tfnvngirtf fhyqpfsqmn qslrsvfdff radiitfqel 61 kteklsiskw grvdgfysfi sipqtrkgys gvgcwiripe knhplyhalq vvkaeegitg 121 yltikngkhs aisyrndvnq giggydsldp dldeksalel dsegrcvmve lacgiviisv 181 ycpansnsse egemfrlrfl kvllrrvrnl dkigkkivlm gdvnvcrdli dsadtleqfs 241 ipitdpmggt kleaqyrdka iqfiinpdtp hrrifnqila dsllpdaskr gilidttrli 301 qtrnrlkmyt vwnmlknlrp snygsridfi lvslklerci kaadilpdil gsdhcpvysd 361 ldilddriep gttqvpipkf earykynlrn hnvlemfakk dtnkesnkqk ycvskvmntk 421 knsniknksl dsffqkvnge kddrikesse ipqqakkris tpklnfkdvf gkpplcrhge 481 esmlktskts anpgrkfwic krsrgdsnnt esscgffqwv // LOCUS NP_009535 133 aa linear PLN 30-JUN-2025 DEFINITION ribonuclease P [Saccharomyces cerevisiae S288C]. ACCESSION NP_009535 VERSION NP_009535.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178258.1 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 133) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07102. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..133 /product="ribonuclease P" /EC_number="3.1.26.5" /calculated_mol_wt="15381" CDS 1..133 /gene="POP8" /locus_tag="YBL018C" /coded_by="NM_001178258.1:1..402" /experiment="EXISTENCE:direct assay:GO:0000171 ribonuclease MRP activity [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0004526 ribonuclease P activity [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9620854]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]" /note="Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852263" /db_xref="SGD:S000000114" ORIGIN 1 mgkktfrewq yfklsitsfd qdvddahaid qmtwrqwlnn alkrsygifg egveysflhv 61 ddklayirvn hadkdtfsss istyistdel vgspltvsil qessslrlle vtdddrlwlk 121 kvmeeeeqdc kci // LOCUS NP_009536 1579 aa linear PLN 30-JUN-2025 DEFINITION type I sorting receptor [Saccharomyces cerevisiae S288C]. ACCESSION NP_009536 VERSION NP_009536.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178257.1 REFERENCE 1 (residues 1 to 1579) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1579) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1579) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1579) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07103. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1579 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1579 /product="type I sorting receptor" /calculated_mol_wt="177647" Region 45..714 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" Region 752..1379 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" CDS 1..1579 /gene="PEP1" /locus_tag="YBL017C" /gene_synonym="VPS10; VPT1" /coded_by="NM_001178257.1:1..4740" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:20936498]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:31332264]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:31332264]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8187177]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:8187177]" /experiment="EXISTENCE:mutant phenotype:GO:0010209 vacuolar sorting signal binding [PMID:8187177]" /note="Type I transmembrane sorting receptor for multiple vacuolar hydrolases; plays role in post-ER quality control in the Golgi, involved in protein targeting from the endoplasmic reticulum to the vacuole for degradation; cycles between late-Golgi and prevacuolar endosome-like compartments; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:852264" /db_xref="SGD:S000000113" ORIGIN 1 millhfvysl walllipltn aeeftpkvtk tiaqdsfdil sfddsntlir kqdtsvtisf 61 ddgetwekve giegeitwiy idpfnrhdra vatamngsyl yitndqgksw eritlpdsge 121 sisprecyie thplnknyfl akcnycekte vnndneensg deegqfeifn itrctdkvfa 181 sndggksfse iksslernen spisisdcgf aktskdsdle ssdtsiiclf qnmqlimdef 241 sspytesklv lttdwgkslk efdqfkdkvv ngyrilkshm vvltqgdryn dmssmdvwvs 301 ndlsnfkmay mptqlrhsmq geiyedamgr iilpmsrers dqeedkgivs eilisdsqgl 361 kfspipwtan evfgyinfyq ptylkgtmia slyplsrrrn rkgkakgvks kgvtkisvdn 421 gltwtmlkvv dpdnadsfdc ditdfencsl qnmfytregs tptagilmtt givgdgsvfd 481 wgdqrtfisr dggltwklaf dfpclyavgd ygnvivaipy nadedddpqs efyysldqgk 541 twteyqlett iypnevmntt pdgsgakfil ngftlahmdg ttnfiyaidf stafndktce 601 endfedwnla egkcvngvky kirrrkqdaq clvkkvfedl qlfetacdkc teadyecafe 661 fvrdatgkcv pdynlivlsd vcdktkkktv pvkplqlvkg dkckkpmtvk svdiscegvp 721 kkgtndkeiv vtenkfdfki qfyqyfdtvt desllminsr geayishdgg qtikrfdsng 781 etiievvfnp yynssaylfg skgsifsthd rgysfmtakl pearqlgmpl dfnakaqdtf 841 iyyggknces ilspechava yltndggetf temldnaihc efagslfkyp snedmvmcqv 901 kekssqtrsl vsstdffqdd kntvfeniig ylstggyiiv avphennelr ayvtidgtef 961 aeakfpyded vgkqeaftil esekgsiflh latnlvpgrd fgnllksnsn gtsfvtleha 1021 vnrntfgyvd fekiqglegi iltnivsnsd kvaenkedkq lktkitfneg sdwnflkppk 1081 rdsegkkfsc ssksldecsl hlhgyterkd irdtyssgsa lgmmfgvgnv gpnllpykec 1141 stffttdgge twaevkktph qweygdhggi lvlvpenset dsisystdfg ktwkdykfca 1201 dkvlvkditt vprdsalrfl lfgeaadigg ssfrtytidf rniferqcdf ditgkesady 1261 kysplgsksn clfghqtefl rktdencfig niplsefsrn ikncsctrqd fecdynfyka 1321 ndgtcklvkg lspanaadvc kkepdlieyf essgyrkipl stcegglkld apssphacpg 1381 kekefkekys vsagpfafif isilliiffa awfvydrgir rnggfarfge irlgddglie 1441 nnntdrvvnn ivksgfyvfs nigsllqhtk tniahaiski rgrfgnrtgp sysslihdqf 1501 ldeaddllag hdedandlss fmdqgsnfei eeddvptlee ehtsytdqpt ttdvpdtlpe 1561 gneenidrpd stapsnenq // LOCUS NP_009537 353 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated serine/threonine-protein kinase FUS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009537 VERSION NP_009537.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178256.1 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 353) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07104. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..353 /product="mitogen-activated serine/threonine-protein kinase FUS3" /EC_number="2.7.11.24" /calculated_mol_wt="40641" Region 7..353 /region_name="STKc_ERK1_2_like" /note="Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; cd07849" /db_xref="CDD:270839" Site order(19..22,24..25,27,40,42,58,72,93..96,99,101..102,137, 139,141..142,144,154..155,158,180,182..185,187,225) /site_type="active" /db_xref="CDD:270839" Site order(19..22,24..25,27,40,42,72,93..96,99,102,141..142,144, 154..155) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270839" Site order(58,101,137,139,158,180,182..185,187,225) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270839" Site order(69,97..98,102..103,106..107,112..113,116,119,123, 145..150,312,314,317) /site_type="other" /note="KIM docking site [polypeptide binding]" /db_xref="CDD:270839" Site order(154..164,169..175,179..187) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270839" CDS 1..353 /gene="FUS3" /locus_tag="YBL016W" /gene_synonym="DAC2" /coded_by="NM_001178256.1:1..1062" /experiment="EXISTENCE:direct assay:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:15620357]" /experiment="EXISTENCE:direct assay:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8384702|PMID:15620357]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004707 MAP kinase activity [PMID:15620357|PMID:8384702]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18417610|PMID:10233162]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10233162]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:17952059|PMID:11781566]" /experiment="EXISTENCE:direct assay:GO:0071507 pheromone response MAPK cascade [PMID:8159759]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:10652102|PMID:15620357|PMID:8001818]" /experiment="EXISTENCE:mutant phenotype:GO:0010526 transposable element silencing [PMID:9566871]" /experiment="EXISTENCE:mutant phenotype:GO:0046827 positive regulation of protein export from nucleus [PMID:22588722]" /experiment="EXISTENCE:physical interaction:GO:0043409 negative regulation of MAPK cascade [PMID:16424299]" /note="Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its; inhibits recruitment of Ste5p, Cdc42p-mediated asymmetry and mating morphogenesis" /db_xref="GeneID:852265" /db_xref="SGD:S000000112" ORIGIN 1 mpkrivynis sdfqlksllg egaygvvcsa thkptgeiva ikkiepfdkp lfalrtlrei 61 kilkhfkhen iitifniqrp dsfenfnevy iiqelmqtdl hrvistqmls ddhiqyfiyq 121 tlravkvlhg snvihrdlkp snllinsncd lkvcdfglar iidesaadns eptgqqsgmt 181 eyvatrwyra pevmltsaky sramdvwscg cilaelflrr pifpgrdyrh qlllifgiig 241 tphsdndlrc iesprareyi kslpmypaap lekmfprvnp kgidllqrml vfdpakrita 301 kealehpylq tyhdpndepe gepippsffe fdhykealtt kdlkkliwne ifs // LOCUS NP_009538 526 aa linear PLN 30-JUN-2025 DEFINITION acetyl-CoA hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009538 VERSION NP_009538.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178255.1 REFERENCE 1 (residues 1 to 526) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 526) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 526) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 526) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07105. Method: conceptual translation. FEATURES Location/Qualifiers source 1..526 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..526 /product="acetyl-CoA hydrolase" /EC_number="3.1.2.1" /calculated_mol_wt="58581" Region 22..516 /region_name="YgfH_subfam" /note="succinate CoA transferase; TIGR03458" /db_xref="CDD:274588" CDS 1..526 /gene="ACH1" /locus_tag="YBL015W" /coded_by="NM_001178255.1:1..1581" /experiment="EXISTENCE:direct assay:GO:0003986 acetyl-CoA hydrolase activity [PMID:12606555]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:12606555|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11746603]" /experiment="EXISTENCE:direct assay:GO:0008775 acetate CoA-transferase activity [PMID:19298859]" /experiment="EXISTENCE:mutant phenotype:GO:0006083 acetate metabolic process [PMID:8841387]" /note="Protein with CoA transferase activity; particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth" /db_xref="GeneID:852266" /db_xref="SGD:S000000111" ORIGIN 1 mtisnllkqr vryapylkkv keaheliplf kngqylgwsg ftgvgtpkav pealidhvek 61 nnlqgklrfn lfvgasagpe enrwaehdmi ikraphqvgk piakainqgr ieffdkhlsm 121 fpqdltygfy trerkdnkil dytiieatai kedgsivpgp svggspefit vsdkviievn 181 tatpsfegih didmpvnppf rkpypylkvd dkcgvdsipv dpekvvaive stmrdqvppn 241 tpsddmsrai aghlveffrn evkhgrlpen llplqsgign ianaviegla gaqfkhltvw 301 tevlqdsfld lfengsldya tatsvrltek gfdrafanwe nfkhrlclrs qvvsnnpemi 361 rrlgviamnt pvevdiyaha nstnvngsrm lnglggsadf lrnaklsimh apsarptkvd 421 ptgistivpm ashvdqtehd ldilvtdqgl adlrglspke rareiinkca hpdyqalltd 481 yldraehyak khnclhephm lknafkfhtn laekgtmkvd swepvd // LOCUS NP_009539 894 aa linear PLN 30-JUN-2025 DEFINITION Rrn6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009539 VERSION NP_009539.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178254.2 REFERENCE 1 (residues 1 to 894) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 894) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 894) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 894) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07106. On Apr 26, 2011 this sequence version replaced NP_009539.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..894 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..894 /product="Rrn6p" /calculated_mol_wt="101918" Region 175..878 /region_name="Rrn6" /note="RNA polymerase I-specific transcription-initiation factor; pfam10214" /db_xref="CDD:431141" CDS 1..894 /gene="RRN6" /locus_tag="YBL014C" /coded_by="NM_001178254.2:1..2685" /experiment="EXISTENCE:direct assay:GO:0001163 RNA polymerase I transcription regulatory region sequence-specific DNA binding [PMID:20421203]" /experiment="EXISTENCE:direct assay:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:11032814]" /experiment="EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:7958901]" /experiment="EXISTENCE:direct assay:GO:0070860 RNA polymerase I core factor complex [PMID:7958901|PMID:8702872|PMID:8887672]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:7958901]" /experiment="EXISTENCE:physical interaction:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:11032814]" /note="Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p" /db_xref="GeneID:852269" /db_xref="SGD:S000000110" ORIGIN 1 msegqipssd vlgsqlgvgv qgaslycpqe nyttkkqekp qwlrpvddtl aedaldlhiv 61 vksllcdtai ryisddkvlq esdadddlit sdidedtdnq gdtsivvnpv ipvvpkdvhf 121 fkkvdvgnds mfgvncdtpv sfqdyipsdl lrnlddtlqe stnssrpmqd affwdptvan 181 rldsqyiqta sdlrnyrdgt eiiayasgkt gsvlniavlt rqntlhlnrh nnvtsielhs 241 piksikipga sesigrrsnl vgiitensfq ifriesvhsr scdvmvssse plyfveiddl 301 qvvdfafnpw dlqqfaiidi kgnwsigrip knfnnnnkrk lqlidnlhgt ifdpeelssw 361 kriewfshfq kilvfdrskm ieidfmnnwq tevvqakaws nirdykridd kngilltsre 421 iiivgasesn dpvrriswkh dldpddttlr itvqkvkkpd hillvafvys mrhkriymhv 481 fshrkanlfq slgcstvlei pggtptgiet iltldhidde srreedaden felvvdflvk 541 lrnssevyyy alsntqnsep nkqetpiivd hpewaslfnn aderekesig alvsqiklke 601 rerisrvqnl iehenshded kylqdlgyrl siatnelles wqktkdesil sgslshsklk 661 nllensdsfa sipefsslld qffqyyqdqd vtfigfekll hlflhedvpg ldifynkllq 721 cwvlvspqae lltkeivkdi iwslarlekp slfepiqnei srslsgpyqd iisswdmddi 781 needesnefn fdsqfsapfn grppfnlnsq sqiptikssq ssglarrkri lktqsqkatp 841 lsqstqnlsv lpdsmtpaft lmqppssqis fvndsqprns qkakkkkkri rgfg // LOCUS NP_009540 401 aa linear PLN 30-JUN-2025 DEFINITION methionyl-tRNA formyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009540 VERSION NP_009540.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178253.1 REFERENCE 1 (residues 1 to 401) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 401) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 401) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 401) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07107. On Feb 2, 2004 this sequence version replaced NP_009540.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..401 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..401 /product="methionyl-tRNA formyltransferase" /EC_number="2.1.2.9" /calculated_mol_wt="44486" Region 30..393 /region_name="fmt" /note="methionyl-tRNA formyltransferase; TIGR00460" /db_xref="CDD:273088" CDS 1..401 /gene="FMT1" /locus_tag="YBL013W" /coded_by="NM_001178253.1:1..1206" /experiment="EXISTENCE:direct assay:GO:0004479 methionyl-tRNA formyltransferase activity [PMID:12549912]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:5277072]" /experiment="EXISTENCE:direct assay:GO:0071951 conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [PMID:12549912]" /experiment="EXISTENCE:mutant phenotype:GO:0004479 methionyl-tRNA formyltransferase activity [PMID:10781559]" /experiment="EXISTENCE:mutant phenotype:GO:0071951 conversion of methionyl-tRNA to N-formyl-methionyl-tRNA [PMID:10781559]" /note="Methionyl-tRNA formyltransferase; catalyzes formylation of mitochondria initiator Met-tRNA and residual cytosolic Met-tRNA due to inefficient translocation into the mitochondrial matrix; starvation or stationary phase entry increases Gcn2p phosphorylation-mediated cytosolic retention of Fmt1p, enhancing N-terminal protein formylation and ultimately N-end rule pathway mediated destruction that involves the Psh1p ubiquitin ligase; potential Cdc28p substrate" /db_xref="GeneID:852270" /db_xref="SGD:S000000109" ORIGIN 1 mvkmrritpt rllftcryis nnasppvqpl nvlffgsdtf snfslqalne lrqnngscgi 61 vdniqvvtrs pkwcgrqksi lkyppifdma eklqlprpit cdtkqemlal skltpsrqgn 121 pendgsgapf naiiavsfgk lipgdlirav plalnvhpsl lprhkgsapi qrallegdty 181 tgvtiqtlhp drfdhgaiva qteplaiatm lskgrvndst adfnseglpr rtailmdqlg 241 algaqllgqt lrerlylpqn rvqaptaykp syahritted krihwardsa aellnkletl 301 gplhafkeat aarkdaqnsv lkrilfheck vmrdarldng skpgmfkydd ikdcilvtcr 361 gnlllcvsrl qfegfavera gqfmarlrkr cgalseklvf l // LOCUS NP_009542 759 aa linear PLN 30-JUN-2025 DEFINITION bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009542 VERSION NP_009542.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178251.1 REFERENCE 1 (residues 1 to 759) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 759) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 759) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 759) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07108. Method: conceptual translation. FEATURES Location/Qualifiers source 1..759 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..759 /product="bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase SCT1" /EC_number="2.3.1.15" /EC_number="2.3.1.42" /calculated_mol_wt="85564" Region 56..343 /region_name="LPLAT_AAK14816-like" /note="Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; cd07992" /db_xref="CDD:153254" Site order(90,93,96,116..119,253..255) /site_type="active" /note="putative acyl-acceptor binding pocket [active]" /db_xref="CDD:153254" CDS 1..759 /gene="SCT1" /locus_tag="YBL011W" /gene_synonym="GAT2" /coded_by="NM_001178251.1:1..2280" /experiment="EXISTENCE:direct assay:GO:0004366 glycerol-3-phosphate O-acyltransferase activity [PMID:11544256]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762|PMID:19525420]" /experiment="EXISTENCE:direct assay:GO:0016287 glycerone-phosphate O-acyltransferase activity [PMID:11544256]" /experiment="EXISTENCE:mutant phenotype:GO:0004366 glycerol-3-phosphate O-acyltransferase activity [PMID:11544256]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:11544256]" /note="Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; dual substrate-specific acyltransferase of the glycerolipid biosynthesis pathway; prefers 16-carbon fatty acids; similar to Gpt2p; gene is constitutively transcribed" /db_xref="GeneID:852271" /db_xref="SGD:S000000107" ORIGIN 1 mpapkltekf asskstqktt nyssieaksv ktsadqayiy qepsatkkil ysiatwllyn 61 ifhcffreir grgsfkvpqq gpvifvaaph anqfvdpvil mgevkksvnr rvsfliaess 121 lkqppigfla sffmaigvvr pqdnlkpaeg tirvdptdyk rvighdthfl tdcmpkglig 181 lpksmgfgei qsiesdtslt lrkefkmakp eiktalltgt tykyaakvdq scvyhrvfeh 241 lahnncigif peggshdrtn llplkagvai malgcmdkhp dvnvkivpcg mnyfhphkfr 301 sravvefgdp ieipkelvak yhnpetnrda vkelldtisk glqsvtvtcs dyetlmvvqt 361 irrlymtqfs tklplplive mnrrmvkgye fyrndpkiad ltkdimayna alrhynlpdh 421 lveeakvnfa knlglvffrs iglcilfsla mpgiimfspv filakrisqe kartalskst 481 vkikandvia twkiligmgf apllyifwsv lityylrhkp wnkiyvfsgs yiscvivtys 541 alivgdigmd gfkslrplvl sltspkglqk lqkdrrnlae riievvnnfg selfpdfdsa 601 alreefdvid eeeedrktse lnrrkmlrkq kikrqekdss spiisqrdnh dayehhnqds 661 dgvslvnsdn slsniplfss tfhrksessl astsvapsss sefeveneil eeknglaski 721 aqavlnkrig entareeeee eeeeeeeeee eeegkegda // LOCUS NP_009543 280 aa linear PLN 30-JUN-2025 DEFINITION Laa2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009543 VERSION NP_009543.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178250.1 REFERENCE 1 (residues 1 to 280) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 280) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 280) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 280) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07109. Method: conceptual translation. FEATURES Location/Qualifiers source 1..280 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..280 /product="Laa2p" /calculated_mol_wt="32508" CDS 1..280 /gene="LAA2" /locus_tag="YBL010C" /coded_by="NM_001178250.1:1..843" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:30523155]" /experiment="EXISTENCE:mutant phenotype:GO:0035653 clathrin-coated vesicle cargo loading, AP-1-mediated [PMID:30523155]" /note="Clathrin adaptor (adaptin) accessory protein; physically interacts with and is involved in localization of clathrin adaptor protein complex-1 (AP-1); green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles" /db_xref="GeneID:852273" /db_xref="SGD:S000000106" ORIGIN 1 msdrdqiepv tnaldaesds sddfgnfsda svendlynqn stlttssesv vdnclnkilp 61 kgefdleeet ikndcfklsk liederphvi yeqlvqldpv lqpfiwnksh irrnllhilr 121 lsdnngsegv gtkreeepln delfkricda vekneqtatg lflrdnfkid ytppmtlksl 181 qkeeereqeq hipqllmadf tsmdeeslrq yhdtlcqsid flvsksrslk kqqrdllkdk 241 ttfenvvtnl tghtqrlqrd eialynkkrn kkkrfswvgy // LOCUS NP_009544 676 aa linear PLN 30-JUN-2025 DEFINITION protein kinase ALK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009544 VERSION NP_009544.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178249.1 REFERENCE 1 (residues 1 to 676) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 676) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 676) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 676) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07110. Method: conceptual translation. FEATURES Location/Qualifiers source 1..676 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..676 /product="protein kinase ALK2" /EC_number="2.7.11.1" /calculated_mol_wt="76242" Region 136..672 /region_name="ALK1" /note="Serine/threonine kinase of the haspin family [Cell division and chromosome partitioning]; COG5072" /db_xref="CDD:227404" CDS 1..676 /gene="ALK2" /locus_tag="YBL009W" /coded_by="NM_001178249.1:1..2031" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16855400]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:33585466]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:16855400]" /experiment="EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:33585466]" /note="Atypical protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of formins and polarisome components in mitosis, and survival after spindle assembly checkpoint delay; negatively regulates the morphogenesis checkpoint in response to polarity insults in opposition to ALK1; phosphorylated in response to DNA damage; similar to mammalian haspins" /db_xref="GeneID:852274" /db_xref="SGD:S000000105" ORIGIN 1 mnfdavadqq mtdrryfale vaesddadss lnsssmgspa vdvgrkvyki tshkgsaede 61 sqsfftssds ptsktrpvgk tienddyygk rsstgsslkq lfnkinindt ahssnkenvs 121 qsvlsenkll spskrlskqg ltkvtnskfr tplrpisnqs tlsrdepvkd frslkfrsgs 181 dfkcwgdekt sshvhsssvn svnsftstts sskwkfwknd nllsrslssr svndqdpnfv 241 qpkptnslqk kssissfhns ifgggkhtek krnsgfimpd hqstkelnhk hsssnlsfrs 301 lkhktshssl nklkvrrkgn tqelnhpikk tcqislpvpd qvskdkiqlk lknstslasl 361 ssevtpintl dyndsilqqi lqlcdvkyil hdlreaqslg lftlntrsvq lshnfwqtyh 421 sdmqtslick kvclgalsdl ttsnlislhe lkslrliqgt sgvanllqay vvpsnqcend 481 qnlilylffk yqgtplsrcs nidysqalsi fwqcssilyv aeskfqlehr nltldhilid 541 skgnvtlidm kccrflnidn nkasytrldh hyffqgrgtl qfeiyelmrs mlpqpiswat 601 feprtnllwl yhlsssllkm akkavvsgal nreeniliel thlldparkh sktifkkelv 661 irtcgdllsl kgeimq // LOCUS NP_878046 79 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBL008W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878046 VERSION NP_878046.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184539.1 REFERENCE 1 (residues 1 to 79) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 79) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 79) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 79) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07111. Method: conceptual translation. FEATURES Location/Qualifiers source 1..79 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..79 /product="uncharacterized protein" /calculated_mol_wt="9350" CDS 1..79 /locus_tag="YBL008W-A" /coded_by="NM_001184539.1:1..240" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466442" /db_xref="SGD:S000028529" ORIGIN 1 mkmnpctvil ckslfffclf qvdcycnrkn iqnqssriat kikrsywfrw qkhiilanih 61 kiikayqrsi iklpvtkgl // LOCUS NP_009545 840 aa linear PLN 30-JUN-2025 DEFINITION Hir1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009545 VERSION NP_009545.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178248.2 REFERENCE 1 (residues 1 to 840) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 840) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 840) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 840) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07112. On Apr 26, 2011 this sequence version replaced NP_009545.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..840 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..840 /product="Hir1p" /calculated_mol_wt="93727" Region <20..387 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 20..66 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 83..135 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 140..176 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 183..228 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 235..275 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 283..350 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 359..383 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 735..>807 /region_name="Hira" /note="TUP1-like enhancer of split; pfam07569" /db_xref="CDD:462211" CDS 1..840 /gene="HIR1" /locus_tag="YBL008W" /coded_by="NM_001178248.2:1..2523" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9001207]" /experiment="EXISTENCE:direct assay:GO:0000417 HIR complex [PMID:16303565|PMID:16264190]" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:11782447]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16264190]" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9001207]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:16303565|PMID:16264190]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:16449659]" /experiment="EXISTENCE:genetic interaction:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:23962978]" /experiment="EXISTENCE:mutant phenotype:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:23962978]" /experiment="EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:16264190]" /experiment="EXISTENCE:physical interaction:GO:0000417 HIR complex [PMID:16264190]" /note="Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores" /db_xref="GeneID:852275" /db_xref="SGD:S000000104" ORIGIN 1 mkvvkfpwla hreesrkyei ytvdvshdgk rlatggldgk iriwsidsil rcmelesltp 61 eiplpqdlqm plcsmsrhtg sitcvkfspd gkylasgsdd rilliwalde eqssqpafgs 121 eherehwtvr krlvahdndi qdicwapdss ilvtvgldrs vivwngstfe klkrfdvhqs 181 lvkgvvfdpa nkyfattsdd rtmkifryhk tgdisftieh iitepfkesp lttyfrrpsw 241 spdgqhiavp natngpvssv aivnrgtwdt nvslighdap tevarfnprl fernagvkqk 301 kdddpenalv gqnddkvhhf dknidsvvat agqdkslavw stsrprpilv afdianksit 361 dmswnpdgsl lfvasldssi tlfkfennel gkpipleknm eqlyrygvdk dsldfpesin 421 qllledqtks fkhtkistsk lgenhptlat nsasnqkdnn dasvsrsehi nilipkrkkd 481 ailnkavtlk sgkkrvaptl istsssspfs ngikkptlds kriennvkss tktinskntl 541 lnvpegvekk isissfplpr lgihslimgt kersawkisn selenddadn aggkgsdgts 601 nsiddiavls eeendfhrmt lnakltqeki wseepttrcl lqsdvipdtd vvvleggsld 661 diavleirng versiqfdse alldnptril gyqggkrtie tfipeviica igskdckcwc 721 lasangsiyi lsyngqqrip kiclghkvik mvtsskyllv lterglffaw dlldlklvlr 781 nvpilpilng qpihgnkvri nkvikcfrld gsscdlllev gdpknvykwt kdlgcwslyk // LOCUS NP_009546 1244 aa linear PLN 30-JUN-2025 DEFINITION cytoskeletal protein-binding protein SLA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009546 VERSION NP_009546.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178247.1 REFERENCE 1 (residues 1 to 1244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1244) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07113. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1244 /product="cytoskeletal protein-binding protein SLA1" /calculated_mol_wt="135717" Region 7..64 /region_name="SH3_Sla1p_1" /note="First Src Homology 3 domain of the fungal endocytic adaptor protein Sla1p; cd11773" /db_xref="CDD:212707" Site order(12,14,17,21,40..41,61,63..64) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212707" Region 73..127 /region_name="SH3" /note="Src Homology 3 domain superfamily; cl17036" /db_xref="CDD:473055" Site order(78,80,83,89,107..108,123,125..126) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212690" Region 356..412 /region_name="SH3_Sla1p_3" /note="Third Src Homology 3 domain of the fungal endocytic adaptor protein Sla1p; cd11775" /db_xref="CDD:212709" Site order(362..365,371,389..391,406..409) /site_type="other" /note="ubiquitin binding site [polypeptide binding]" /db_xref="CDD:212709" Site order(362,364,367,371,390..391,406,408..409) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212709" Region 489..554 /region_name="SHD1" /note="SLA1 homology domain 1, SHD1; pfam03983" /db_xref="CDD:427630" Region 655..716 /region_name="SAM_SLA1_fungal" /note="SAM domain of SLA1 subfamily; cd09532" /db_xref="CDD:188931" Region <723..1040 /region_name="DUF5585" /note="Family of unknown function (DUF5585); pfam17823" /db_xref="CDD:465521" Region 967..>1230 /region_name="Med15" /note="ARC105 or Med15 subunit of Mediator complex non-fungal; pfam09606" /db_xref="CDD:312941" CDS 1..1244 /gene="SLA1" /locus_tag="YBL007C" /coded_by="NM_001178247.1:1..3735" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17286805]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11950888]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:16824951|PMID:10198057]" /experiment="EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:12814545|PMID:22973053]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:17244534]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0140224 SLAC complex [PMID:22973053]" /experiment="EXISTENCE:direct assay:GO:1990964 actin cytoskeleton-regulatory complex [PMID:10594004]" /experiment="EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:8335689|PMID:10198057]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:17286805]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:17363896|PMID:11940605]" /experiment="EXISTENCE:mutant phenotype:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:12814545]" /experiment="EXISTENCE:mutant phenotype:GO:0140312 cargo adaptor activity [PMID:17363896|PMID:11940605|PMID:17065552]" /experiment="EXISTENCE:physical interaction:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:22973053]" /experiment="EXISTENCE:physical interaction:GO:0140224 SLAC complex [PMID:22973053]" /note="Cytoskeletal protein binding protein; required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains with a PH-like domain amid them at residues 253-339 which confers lipid-binding properties" /db_xref="GeneID:852276" /db_xref="SGD:S000000103" ORIGIN 1 mtvflgiyra vyayepqtpe elaiqeddll yllqksdidd wwtvkkrvig sdseepvglv 61 pstyieeapv lkkvraiydy eqvqnadeel tfhendvfdv fddkdadwll vkstvsnefg 121 fipgnyvepe ngstskqeqa paaaeapaat paaapasaav lptnflpppq hndrarmmqs 181 kedqapdede egpppampar ptattettda taaavrsrtr lsysdndndd eeddyyynsn 241 snnvgnheyn teyhswnvte iegrkkkkak lsignnkinf ipqkgtphew sidklvsydn 301 ekkhmflefv dpyrslelht gntttceeim niigeykgas rdpglrevem askskkrgiv 361 qydfmaesqd eltiksgdkv yilddkkskd wwmcqlvdsg ksglvpaqfi epvrdkkhte 421 stasgiiksi kknftkspsr srsrsrsksn anaswkddel qndvvgsaag krsrksslss 481 hkknssatkd fpnpkksrlw vdrsgtfkvd aefigcakgk ihlhkangvk iavaadklsn 541 edlayvekit gfslekfkan dgsssrgtds rdsererrrr lkeqeekerd rrlkerelye 601 lkkarellde ersrlqekel ppikpprpts ttsvpnttsv ppaessnnnn ssnkydwfef 661 flncgvdvsn cqrytinfdr eqltedmmpd innsmlrtlg lregdivrvm khldkkfgre 721 niasiptnat gnmfsqpdgs lnvatspets lpqqllpqtt spaqtapsts aetddawtvk 781 pasksesnll skkseftgsm qdlldlqple pkkaaastpe pnlkdlepvk tggttvpaap 841 vssapvssap apldpfktgg nnilplstgf vmmpmitggd mlpmqrtggf vvpqttfgmq 901 sqvtggilpv qktgnglipi sntggammpq ttfgaaatvl plqktgggli piattggaqf 961 pqtsfnvqgq qqlptgsilp vqktanglis antgvsmptv qrtggtmipq tsfgvsqqlt 1021 ggammtqpqn tgsammpqts fnavpqitgg ammpqtsfna lpqvtggamm plqrtggaln 1081 tfntggamip qtsfssqaqn tggfrpqsqf gltlqktggi aplnqnqftg gamntlstgg 1141 vlqqqqpqtm ntfntggvmq elqmmttfnt ggamqqpqmm ntfntdgimq qpqmmntfnt 1201 ggamqqpqqq alqnqptgfg fgngpqqsrq anifnatasn pfgf // LOCUS NP_009547 180 aa linear PLN 30-JUN-2025 DEFINITION Ldb7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009547 VERSION NP_009547.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178246.1 REFERENCE 1 (residues 1 to 180) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 180) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 180) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 180) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07114. On Feb 2, 2004 this sequence version replaced NP_009547.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..180 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..180 /product="Ldb7p" /calculated_mol_wt="19661" Region 7..106 /region_name="Rsc14" /note="RSC complex, Rsc14/Ldb7 subunit; pfam08586" /db_xref="CDD:400759" CDS 1..180 /gene="LDB7" /locus_tag="YBL006C" /gene_synonym="RSC14" /coded_by="NM_001178246.1:1..543" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019|PMID:12183366]" /experiment="EXISTENCE:genetic interaction:GO:0016586 RSC-type complex [PMID:16204215]" /experiment="EXISTENCE:mutant phenotype:GO:0016586 RSC-type complex [PMID:16204215]" /experiment="EXISTENCE:physical interaction:GO:0016586 RSC-type complex [PMID:16204215]" /note="Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions" /db_xref="GeneID:852277" /db_xref="SGD:S000000102" ORIGIN 1 msgsnmgyyd vlaglsalek ssqvvfsate lqqltqqsha tdkgiegsen skakvskpkr 61 vavhgylggk vsladaaqve yevghsllgs yvprqqleal ssvdfshhfh rtleckaale 121 thdvflagag qlslpfqshi esprnseakr krkviickrc qsrfigshrr sqlrehacvd // LOCUS NP_009548 976 aa linear PLN 30-JUN-2025 DEFINITION drug-responsive transcription factor PDR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009548 VERSION NP_009548.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178245.1 REFERENCE 1 (residues 1 to 976) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 976) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 976) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 976) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 976) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 976) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 976) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07115. Method: conceptual translation. FEATURES Location/Qualifiers source 1..976 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..976 /product="drug-responsive transcription factor PDR3" /calculated_mol_wt="112441" Region 9..49 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(10,14,19..22,24,27,36) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(15,18,25,31,34,41) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region <446..601 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..976 /gene="PDR3" /locus_tag="YBL005W" /gene_synonym="AMY2; TPE2" /coded_by="NM_001178245.1:1..2931" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8798494]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:22842922|PMID:11136452]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:genetic interaction:GO:2001040 positive regulation of cellular response to drug [PMID:8078477]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9428726|PMID:8798494]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8798494|PMID:9428726]" /experiment="EXISTENCE:mutant phenotype:GO:0071466 cellular response to xenobiotic stimulus [PMID:8798494|PMID:9428726]" /experiment="EXISTENCE:mutant phenotype:GO:2001040 positive regulation of cellular response to drug [PMID:8078477|PMID:9767597]" /note="Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting PDRE sites (PDR responsive elements); has a role in response to drugs and organic solvents; post-translationally up-regulated in cells lacking functional mitochondrial genome; involved in diauxic shift; relative distribution to nucleus increases upon DNA replication stress; APCC(Cdh1) substrate" /db_xref="GeneID:852278" /db_xref="SGD:S000000101" ORIGIN 1 mkvkkstrsk vstacvncrk rkikctgkyp ctncisydct cvflkkhlpq kedssqslpt 61 tavappssha nveasadvqh ldtaikldnq yyfklmndli qtpvspsath apdtsnnptn 121 dnnilfkdds kyqnqlvtyq niltnlyalp pcddtqllid ktksqlnnli nswnpeinyp 181 klssfsprpq rsietylltn kyrnkihmtr fsfwtdqmvk sqspdsflat tplvdevfgl 241 fspiqafslr gigylikkni entgssmlid tketiylilr lfdlcyehli qgcisisnpl 301 enylqkikqt ptttasaslp tspaplsndl visvihqlpq pfiqsitgft ttqlienlhd 361 sfsmfrivtq myaqhrkrfa eflnqafslp hqeksvlfss fcsseyllst lcyayynvtl 421 yhmldintld yleilvslle iqneiderfg fekmlevavt cstkmglsrw eyyvgident 481 aerrrkiwwk iyslekrflt dlgdlsline hqmncllpkd frdmgfinhk efltkigtss 541 lspsspklkn lslsrlieyg elaiaqivgd ffsetlynek ftslevsvkp tiirqkllek 601 vfediesfrl klakiklhts rvfqvahcky peypkndlie aakfvsyhkn twfsilgavn 661 nliarlsedp eviteqsmky anemfqewre inqfliqvdt dfivwacldf yeliffvmas 721 kfyvedphit ledvintlkv fkritniisf fnnnldekdy dcqtfrefsr ssslvaisir 781 iiflkycyae qidraefier lkevepglsd llreffdtrs fiyrymlksv eksgfhliir 841 kmlesdykfl yrdklatgni pdqgnssqis qlydstapsy nnasasaans plklssllns 901 geesytqdas envpcnlrhq drslqqtkrq hsapsqisan enniynlgtl eefvssgdlt 961 dlyhtlwndn tsypfl // LOCUS NP_009550 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009550 VERSION NP_009550.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180047.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 440) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07117. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..440 /product="gag protein" /calculated_mol_wt="49154" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YBL005W-A" /coded_by="NM_001180047.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:852279" /db_xref="SGD:S000002146" ORIGIN 1 mesqqlsqhs pifhgsacas vtskevqttq dpldisaskt eecekvstqa nsqqpttpps 61 savpenhhha spqaaqvplp qngpypqqrm mntqqanisg wpvyghpslm pyppyqmspm 121 yappgaqsqf tqypqyvgth lntpspesgn sfpdsssaks nmtstnqhvr pppiltspnd 181 flnwvkiyik flqnsnlgdi iptatrkavr qmtddeltfl chtfqlfaps qflppwvkdi 241 lsvdytdimk ilsksinkmq sdtqevndit tlatlhyngs tpadafeaev tnildrlnnn 301 gipinnkvac qfimrglsge ykflpyarhr cihmtvadlf sdihsmyeeq qeskrnksty 361 rrspsdekkd srtytnttkp ksitrnsqkp nnsqsrtara hnvstfnnsp gpdndlirgs 421 ttepiqlknt hdlhlrpgty // LOCUS NP_009549 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009549 VERSION NP_009549.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180048.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1755) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07116. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198839" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region <907..1163 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YBL005W-B" /coded_by="join(NM_001180048.2:1..1305, NM_001180048.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:852280" /db_xref="SGD:S000002147" ORIGIN 1 mesqqlsqhs pifhgsacas vtskevqttq dpldisaskt eecekvstqa nsqqpttpps 61 savpenhhha spqaaqvplp qngpypqqrm mntqqanisg wpvyghpslm pyppyqmspm 121 yappgaqsqf tqypqyvgth lntpspesgn sfpdsssaks nmtstnqhvr pppiltspnd 181 flnwvkiyik flqnsnlgdi iptatrkavr qmtddeltfl chtfqlfaps qflppwvkdi 241 lsvdytdimk ilsksinkmq sdtqevndit tlatlhyngs tpadafeaev tnildrlnnn 301 gipinnkvac qfimrglsge ykflpyarhr cihmtvadlf sdihsmyeeq qeskrnksty 361 rrspsdekkd srtytnttkp ksitrnsqkp nnsqsrtara hnvstfnnsp gpdndlirgs 421 ttepiqlknt hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsn dlniesdhdf qsdielypeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis diestdsggm 1021 hrldvpllap msqsnthess yaskskdfrh sdsysdnetn htnvpisstg gtnnktvpqt 1081 seqetekrii hrspsidtss sesnslhhvv piktsdtcpk enteesiiad lplpdlppep 1141 ptelsdsfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd kyydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny hitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmv lfsknlnsnk 1441 riidklkmqy dtkiinlges deeiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqq eleleeddyk mkvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsk qvldmtyeli qfiwntrdkq liwhkskpvk ptnklvvisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qeldkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_009551 2493 aa linear PLN 30-JUN-2025 DEFINITION Utp20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009551 VERSION NP_009551.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178244.1 REFERENCE 1 (residues 1 to 2493) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2493) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2493) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 2493) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07118. On May 31, 2001 this sequence version replaced NP_009551.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2493 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..2493 /product="Utp20p" /calculated_mol_wt="287430" Region 823..1409 /region_name="DRIM" /note="Down-regulated in metastasis; pfam07539" /db_xref="CDD:462198" Region 1600..1819 /region_name="DUF6700" /note="Domain of unknown function (DUF6700); pfam20416" /db_xref="CDD:466565" CDS 1..2493 /gene="UTP20" /locus_tag="YBL004W" /coded_by="NM_001178244.1:1..7482" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:17652137]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:15590835|PMID:17652137]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:17652137]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911|PMID:17652137]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:17652137]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17652137|PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17652137|PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17652137|PMID:15590835]" /note="Component of the small-subunit (SSU) processome; SSU processome is involved in the biogenesis of the 18S rRNA" /db_xref="GeneID:852282" /db_xref="SGD:S000000100" ORIGIN 1 makqrqttks skryryssfk ariddlkiep arnlekrvhd yvesshflas fdqwkeinls 61 akftefaaei ehdvqtlpqi lyhdkkifns lvsfinfhde fslqplldll aqfchdlgpd 121 flkfyeeaik tlinlldaai efessnvfew gfnclayifk ylskflvkkl vltcdllipl 181 lshskeylsr fsaealsflv rkcpvsnlre fvrsvfekle gddeqtnlye gllilftesm 241 tstqetlhsk akaimsvllh ealtkssper svsllsdiwm niskyasies llpvyevmyq 301 dfndsldatn idrilkvltt ivfsesgrki pdwnkitili erimsqsenc aslsqdkvaf 361 lfalfirnsd vktltlfhqk lfnyaltnis dcfleffqfa lrlsyervfs fnglkflqlf 421 lkknwqsqgk kialfflevd dkpelqkvre vnfpeefils irdffvtaei ndsndlfeiy 481 wraiifkysk lqnteiiipl lerifstfas pdnftkdmvg tllkiyrked dasgnnllkt 541 ildnyenyke slnflrgwnk lvsnlhpses lkglmshyps lllsltdnfm lpdgkiryet 601 lelmktlmil qgmqvpdlls scmvieeipl tlqnardlti riknvgaefg ktktdklvss 661 fflkylfgll tvrfspvwtg vfdtlpnvyt kdealvwklv lsfiklpden qnldyyqpll 721 edgankvlwd ssvvrlrdti dtfshiwsky stqntsiist tierrgntty pilirnqalk 781 vmlsipqvae nhfvdiapfv yndfktykde edmenervit gswtevdrnv flktlskfkn 841 iknvysatel hdhlmvllgs rntdvqklal dallayknpt lnkyrdnlkn llddtlfkde 901 ittfltengs qsikaedekv vmpyvlriff graqvpptsg qkrsrkiavi svlpnfkkpy 961 indflslase rldynyffgn shqinsskat lktirrmtgf vnivnstlsv lrtnfplhtn 1021 svlqpliysi amayyvldte steevhlrkm asnlrqqglk clssvfefvg ntfdwstsme 1081 diyavvvkpr ishfsdenlq qpssllrlfl ywahnpslyq flyydefata talmdtisnq 1141 hvkeavigpi ieaadsiirn pvnddhyvdl vtlictsclk ilpslyvkls dsnsistfln 1201 llvsitemgf iqddhvrsrl isslisilkg klkklqendt qkilkilkli vfnyncswsd 1261 ieelyttiss lfktfdernl rvsltelfie lgrkvpeles isklvadlns ysssrmheyd 1321 fprilstfkg liedgyksys elewlpllft flhfinnkee lalrtnasha imkfidfine 1381 kpnlneasks ismlkdillp niriglrdsl eevqseyvsv lsymvkntky ftdfedmail 1441 lyngdeeadf ftnvnhiqlh rrqraikrlg ehahqlkdns ishylipmie hyvfsddery 1501 rnignetqia igglaqhmsw nqykallrry ismlktkpnq mkqavqlivq lsvplretlr 1561 ivrdgaeskl tlskfpsnld epsnfikqel yptlskilgt rddetiierm piaealvniv 1621 lgltndditn flpsiltnic qvlrskseel rdavrvtlgk isiilgaeyl vfvikelmat 1681 lkrgsqihvl sytvhyilks mhgvlkhsdl dtsssmivki imenifgfag eekdsenyht 1741 kvkeiksnks ydageilasn isltefgtll spvkallmvr inlrnqnkls ellrryllgl 1801 nhnsdseses ilkfchqlfq esemsnspqi pkkkvkdqvd ekedfflvnl esksytinsn 1861 slllnstlqk faldllrnvi trhrsfltvs hlegfipflr dsllsenegv vistlrilit 1921 lirldfsdes seifkncark vlniikvsps tsselcqmgl kflsafirht dstlkdtals 1981 yvlgrvlpdl nepsrqglaf nflkalvskh imlpelydia dttreimvtn hskeirdvsr 2041 svyyqflmey dqskgrlekq fkfmvdnlqy ptesgrqsvm elinliitka npallsklss 2101 sfflalvnvs fnddaprcre masvlistml pklenkdlei vekyiaawlk qvdnasflnl 2161 glrtykvylk sigfehtiel delaikriry ilsdtsvgse hqwdlvysal ntfssymeat 2221 esvykhgfkd iwdgiitcll yphswvrqsa anlvhqlian kdkleisltn leiqtiatri 2281 lhqlgapsip enlanvsikt lvnisilwke qrtpfimdvs kqtgedlkyt taidymvtri 2341 ggiirsdehr mdsfmskkac iqllallvqv ldedeviaeg ekillplygy letyysravd 2401 eeqeelrtls neclkiledk lqvsdftkiy tavkqtvler rkerrskrai lavnapqisa 2461 dkklrkhars rekrkhekde ngyyqrrnkr kra // LOCUS NP_009552 132 aa linear PLN 30-JUN-2025 DEFINITION histone H2A [Saccharomyces cerevisiae S288C]. ACCESSION NP_009552 VERSION NP_009552.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178243.1 REFERENCE 1 (residues 1 to 132) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 132) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 132) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 132) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07119. Method: conceptual translation. FEATURES Location/Qualifiers source 1..132 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..132 /product="histone H2A" /calculated_mol_wt="13858" Region 18..131 /region_name="PTZ00017" /note="histone H2A; Provisional" /db_xref="CDD:185399" CDS 1..132 /gene="HTA2" /locus_tag="YBL003C" /gene_synonym="H2A2" /coded_by="NM_001178243.1:1..399" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15781691]" /note="Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p" /db_xref="GeneID:852283" /db_xref="SGD:S000000099" ORIGIN 1 msggkggkag saakasqsrs akagltfpvg rvhrllrrgn yaqrigsgap vyltavleyl 61 aaeilelagn aardnkktri iprhlqlair nddelnkllg nvtiaqggvl pnihqnllpk 121 ksaktakasq el // LOCUS NP_009553 131 aa linear PLN 30-JUN-2025 DEFINITION histone H2B [Saccharomyces cerevisiae S288C]. ACCESSION NP_009553 VERSION NP_009553.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178242.1 REFERENCE 1 (residues 1 to 131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 131) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07120. Method: conceptual translation. FEATURES Location/Qualifiers source 1..131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..131 /product="histone H2B" /calculated_mol_wt="14106" Region 33..126 /region_name="HFD_H2B" /note="histone-fold domain found in histone H2B and similar proteins; cd22910" /db_xref="CDD:467035" Site order(34,36,39,41,43..45,47..49,52..59,61..62,65..66, 69..70,72..74,76..78,82,92..93,95,98..99,102,105..107,110, 113..115,117..118,121..122,125..126) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467035" Site order(34..40,43..44,46,57..59,92) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:467035" Site order(38,42..44,46..47,50..52,57..59,63,99,103,112..113, 115..116,119..120,122..123,126) /site_type="other" /note="Hif1 binding site [polypeptide binding]" /db_xref="CDD:467035" Site order(65,68..69,71..72,75,80,83,86..88,96..97,100,104..105) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467035" CDS 1..131 /gene="HTB2" /locus_tag="YBL002W" /coded_by="NM_001178242.1:1..396" /note="Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation" /db_xref="GeneID:852284" /db_xref="SGD:S000000098" ORIGIN 1 mssaaekkpa skapaekkpa akktstsvdg kkrskvrket yssyiykvlk qthpdtgisq 61 ksmsilnsfv ndiferiate asklaaynkk stisareiqt avrlilpgel akhavsegtr 121 avtkyssstq a // LOCUS NP_009554 104 aa linear PLN 30-JUN-2025 DEFINITION Ecm15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009554 VERSION NP_009554.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178241.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 104) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07121. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..104 /product="Ecm15p" /calculated_mol_wt="11387" Region 6..102 /region_name="TIGR00106" /note="uncharacterized protein, MTH1187 family" /db_xref="CDD:272908" CDS 1..104 /gene="ECM15" /locus_tag="YBL001C" /coded_by="NM_001178241.1:1..315" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="Non-essential hypothetical protein; likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis" /db_xref="GeneID:852285" /db_xref="SGD:S000000097" ORIGIN 1 mpkifcladv cmvpigtdsa sisdfvalie kkiresplks tlhsagttie gpwddvmgli 61 geiheyghek gyvrvhtdir vgtrtdkhqt aqdkidvvlk kisq // LOCUS NP_009555 780 aa linear PLN 30-JUN-2025 DEFINITION alpha,alpha-trehalase NTH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009555 VERSION NP_009555.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178349.1 REFERENCE 1 (residues 1 to 780) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 780) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 780) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 780) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 780) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 780) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 780) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07122. Method: conceptual translation. FEATURES Location/Qualifiers source 1..780 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..780 /product="alpha,alpha-trehalase NTH2" /EC_number="3.2.1.28" /calculated_mol_wt="89549" Region 135..164 /region_name="Trehalase_Ca-bi" /note="Neutral trehalase Ca2+ binding domain; pfam07492" /db_xref="CDD:429490" Region 192..750 /region_name="Trehalase" /note="pfam01204" /db_xref="CDD:395961" CDS 1..780 /gene="NTH2" /locus_tag="YBR001C" /coded_by="NM_001178349.1:1..2343" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004555 alpha,alpha-trehalase activity [PMID:18065618]" /experiment="EXISTENCE:mutant phenotype:GO:0005993 trehalose catabolic process [PMID:18065618]" /note="Putative neutral trehalase, required for thermotolerance; may mediate resistance to other cellular stresses; NTH2 has a paralog, NTH1, that arose from the whole genome duplication" /db_xref="GeneID:852286" /db_xref="SGD:S000000205" ORIGIN 1 mvdflpkvte inppsegndg ednikplssg seqrplkeeg qqggrrhhrr lssmheyfdp 61 fsnaevyygp itdprkqski hrlnrtrtms vfnkvsdfkn gmkdytlkrr gseddsflss 121 qgnrrfyidn vdlaldella sedtdknhqi tiedtgpkvi kvgtansngf khvnvrgtym 181 lsnllqelti aksfgrhqif ldearinenp vdrlsrlitt qfwtsltrrv dlyniaeiar 241 dskidtpgak npriyvpync peqyefyiqa sqmnpslkle veylpkdita eyvkslndtp 301 gllalameeh vnpstgersl vgypyavpgg rfnelygwds ylmalglies nkvdvargmv 361 ehfifeidhy skilnanrsy ylcrsqppfl tdmallvfek iggknnpnai qllkrafraa 421 ikeykevwms sprldsltgl scyhsdgigi ppetepdhfd tillpyaeky nvtleklryl 481 ynegmikepk ldafflhdra vresghdtty rfegvcayla tidlnsllyk yekdiafvik 541 eyfgneykde ndgtvtdseh weelaelrkt rinkymwded sgfffyyntk lkcrtsyesa 601 ttfwslwagl ateeqakitv ekalpqleml gglvacteks rgpisidrpi rqwdypfgwa 661 phqilawkgl saygyqqvat rlayrwlymi tksfvdyngm vvekydvtrg tdphrvdaey 721 gnqgadfkgv ategfgwvnt syllglkymn nharralaac spplpffnsl kpsekklyyl // LOCUS NP_009556 286 aa linear PLN 30-JUN-2025 DEFINITION ditrans,polycis-polyprenyl diphosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009556 VERSION NP_009556.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178350.1 REFERENCE 1 (residues 1 to 286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 286) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07123. Method: conceptual translation. FEATURES Location/Qualifiers source 1..286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..286 /product="ditrans,polycis-polyprenyl diphosphate synthase" /EC_number="2.5.1.87" /calculated_mol_wt="32563" Region 33..258 /region_name="uppS" /note="undecaprenyl diphosphate synthase; TIGR00055" /db_xref="CDD:129165" Site order(39..44,53,57,61,64,83,91,95,102..103,106,158,207,213, 215) /site_type="active" /db_xref="CDD:259850" Site order(165..166,168..169,172..173,185..187,190,201,212..216, 219..221,223,224,230..231) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:259850" CDS 1..286 /gene="RER2" /locus_tag="YBR002C" /coded_by="NM_001178350.1:1..861" /experiment="EXISTENCE:direct assay:GO:0004659 prenyltransferase activity [PMID:17345630|PMID:9858571]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11442630|PMID:26928762|PMID:24868093|PMID:9858571]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0006486 protein glycosylation [PMID:9858571]" /experiment="EXISTENCE:direct assay:GO:0043048 dolichyl monophosphate biosynthetic process [PMID:10217761|PMID:25066056]" /experiment="EXISTENCE:direct assay:GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity [PMID:11442630|PMID:25066056]" /experiment="EXISTENCE:direct assay:GO:1904423 dehydrodolichyl diphosphate synthase complex [PMID:25066056]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:9858571]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:12911815]" /note="Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1; major enzyme of polyprenol synthesis in both the endoplasmic reticulum (ER) and in lipid droplets; participates in ER protein sorting; human ortholog DHDDS functionally complements the heat sensitive growth defect of a ts allele, and is associated with retinitis pigmentosa" /db_xref="GeneID:852287" /db_xref="SGD:S000000206" ORIGIN 1 metdsgipgh sfvlkwtkni fsrtlrasnc vprhvgfimd gnrrfarkke mdvkegheag 61 fvsmsrilel cyeagvdtat vfafsienfk rssreveslm tlarerirqi tergelacky 121 gvrikiigdl slldkslled vrvavettkn nkratlnicf pytgreeilh amketivqhk 181 kgaaidestl eshlytagvp pldllirtsg vsrlsdfliw qasskgvrie lldclwpefg 241 pirmawillk fsfhksflnk eyrleegdyd eetngdpidl kekkln // LOCUS NP_009557 473 aa linear PLN 30-JUN-2025 DEFINITION trans-hexaprenyltranstransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009557 VERSION NP_009557.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178351.1 REFERENCE 1 (residues 1 to 473) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 473) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 473) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 473) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07124. Method: conceptual translation. FEATURES Location/Qualifiers source 1..473 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..473 /product="trans-hexaprenyltranstransferase" /calculated_mol_wt="52429" Region 48..471 /region_name="Isoprenoid_Biosyn_C1" /note="Isoprenoid Biosynthesis enzymes, Class 1; cl00210" /db_xref="CDD:469660" Site order(185,188..190,192..194,196..197,202..203,255,258, 323..324,327,364..365,368,378,383,388) /site_type="other" /note="substrate binding pocket [chemical binding]" /db_xref="CDD:173833" Site 188..197 /site_type="active" /note="chain length determination region [active]" /db_xref="CDD:173833" Site order(193..194,197,202..203,258,323,364..365,368,378,383, 388) /site_type="active" /note="substrate-Mg2+ binding site [active]" /db_xref="CDD:173833" Site order(193..194,197,202..203,323,364..365) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:173833" Site order(193..194,197,202..203,258,323) /site_type="other" /note="aspartate-rich region 1" /db_xref="CDD:173833" Site order(199..213,371..372,378..383,386..390) /site_type="active" /note="active site lid residues [active]" /db_xref="CDD:173833" Site order(364..365,368,378,383,388) /site_type="other" /note="aspartate-rich region 2" /db_xref="CDD:173833" CDS 1..473 /gene="COQ1" /locus_tag="YBR003W" /coded_by="NM_001178351.1:1..1422" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0000010 heptaprenyl diphosphate synthase activity [PMID:9708911]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:10760477]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:9708911]" /note="Hexaprenyl pyrophosphate synthetase; catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis" /db_xref="GeneID:852288" /db_xref="SGD:S000000207" ORIGIN 1 mfqrsgaahh iklissrrcr fkssfavaln aasklvtpki lwnnpislvs kemntlakni 61 valigsghpv lnkvtsyyfe tegkkvrpll vlllsralse ipmternhlk idksdvpedp 121 iyskpsqnql fqrpassisp lhilhgikpl npltkgpepl peetfdkqrg ilpkqrrlae 181 ivemihtasl lhddvidhsd trrgrpsgna aftnkmavla gdfllgratv sisrlhnpev 241 velmsnsian lvegefmqlk ntsidadidt ienghkllpv pskklevkeh dfrvpsrqqg 301 lqlshdqiie tafeyyihkt ylktaalisk scrcaailsg aspavidecy dfgrnlgicf 361 qlvddmldft vsgkdlgkps gadlklgiat apvlfawked pslgplisrn fsergdvekt 421 idsvrlhngi aktkilaeey rdkalqnlrd slpesdarsa lefltnsilt rrk // LOCUS NP_009558 433 aa linear PLN 30-JUN-2025 DEFINITION GPI-anchor transamidase GPI18 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009558 VERSION NP_009558.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178352.2 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 433) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07125. On Apr 26, 2011 this sequence version replaced NP_009558.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..433 /product="GPI-anchor transamidase GPI18" /calculated_mol_wt="50628" Region 2..433 /region_name="PMT_2" /note="Dolichyl-phosphate-mannose-protein mannosyltransferase; cl21590" /db_xref="CDD:473917" CDS 1..433 /gene="GPI18" /locus_tag="YBR004C" /coded_by="NM_001178352.2:1..1302" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:17615295]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17615295]" /experiment="EXISTENCE:genetic interaction:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:15720390]" /experiment="EXISTENCE:genetic interaction:GO:0000030 mannosyltransferase activity [PMID:15623507]" /experiment="EXISTENCE:genetic interaction:GO:0006506 GPI anchor biosynthetic process [PMID:15623507]" /experiment="EXISTENCE:genetic interaction:GO:0031501 mannosyltransferase complex [PMID:17615295]" /experiment="EXISTENCE:mutant phenotype:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:15720390]" /experiment="EXISTENCE:mutant phenotype:GO:0000030 mannosyltransferase activity [PMID:15720390]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:15720390]" /experiment="EXISTENCE:physical interaction:GO:0031501 mannosyltransferase complex [PMID:17615295]" /note="Functional ortholog of human PIG-V; PIG-V is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria" /db_xref="GeneID:852289" /db_xref="SGD:S000000208" ORIGIN 1 mivgltlyfv lfrsiqyllv fltpirqfdt stslllnelc sspseinsyw nkyfwnklls 61 wdsvffikni tskngkpqfe heyafsqlwt ffvrlfiksn ndsiyhalrv gvaienvlfy 121 lsgivlyflt kkifsqnirq sqfartiakk tsllffltsa agfltsiyse plsfffafvg 181 iwsrecsisv pvlgqfdisw rywfpysfis macftlasln rsncvllgiy fifdlieltk 241 nrkfvkaicf pllsgslmfs allyqqyylp yktfcpqrge wcksqlfssi fitktslysy 301 iqshywgvgl lkywtpnnip nflfavpnii iliyssiyfs kiypsynlka lvwitralvv 361 ivcffahvqi lnriasflpl hlwyladrlv ktsdpkkmen pkgddkivkf yiywlafwip 421 lqtilfaafl ppa // LOCUS NP_009559 213 aa linear PLN 30-JUN-2025 DEFINITION Rcr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009559 VERSION NP_009559.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178353.1 REFERENCE 1 (residues 1 to 213) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 213) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 213) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 213) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07126. Method: conceptual translation. FEATURES Location/Qualifiers source 1..213 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..213 /product="Rcr1p" /calculated_mol_wt="23755" Region 42..155 /region_name="RCR" /note="Chitin synthesis regulation, resistance to Congo red; pfam12273" /db_xref="CDD:432443" CDS 1..213 /gene="RCR1" /locus_tag="YBR005W" /gene_synonym="SSH6" /coded_by="NM_001178353.1:1..642" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:15590673]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:32421152]" /experiment="EXISTENCE:direct assay:GO:0043495 protein-membrane adaptor activity [PMID:32421152]" /experiment="EXISTENCE:direct assay:GO:0072659 protein localization to plasma membrane [PMID:32421152]" /experiment="EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17287526]" /experiment="EXISTENCE:mutant phenotype:GO:0006033 chitin localization [PMID:15590673]" /note="Plasma membrane (PM) ubiquitin ligase-substrate adaptor; involved in cell wall chitin deposition; ubiquitinates and down-regulates chitin synthase Chs3p abundance at PM via calcineurin/Crz1 signaling pathway which regulates RCR1 expression; delivered to PM by exomer complex using novel PM sorting motif; RCR1 has a paralog, RCR2, that arose from the whole genome duplication" /db_xref="GeneID:852290" /db_xref="SGD:S000000209" ORIGIN 1 mglisyenea inevkkadnh hvskfvtsyy gpsssswqsg iwilfvlfva aviliilftf 61 vanrrrrrmg rapirgtawl tppsyrqsqq qytgtvqqrt ddyvpeytet anehdlgyyd 121 qrgefhpndk aayvappplv qecssesvns lerppaavvh qansldtdyg ltrpsngrvp 181 avsdtveqle rlpggtttqe inpperakvn ars // LOCUS NP_009560 497 aa linear PLN 30-JUN-2025 DEFINITION succinate-semialdehyde dehydrogenase (NAD(P)(+)) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009560 VERSION NP_009560.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178354.1 REFERENCE 1 (residues 1 to 497) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 497) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 497) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 497) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07127. Method: conceptual translation. FEATURES Location/Qualifiers source 1..497 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..497 /product="succinate-semialdehyde dehydrogenase (NAD(P)(+))" /EC_number="1.2.1.16" /calculated_mol_wt="54058" Region 37..486 /region_name="SSADH" /note="succinate-semialdehyde dehydrogenase; TIGR01780" /db_xref="CDD:188167" Site order(75,84,125,128..129,131..139,145..147,152,236,248,252, 255,312,316,362,431,433..434,438,440,443,445..451,457, 460..461,467,472,484..490) /site_type="other" /note="tetramerization interface [polypeptide binding]" /db_xref="CDD:143421" Site order(160..164,172,187,189..190,240..243,246,249..250, 264..266,298,396,398,424,462) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:143421" Site order(164,264,295,298) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:143421" CDS 1..497 /gene="UGA2" /locus_tag="YBR006W" /gene_synonym="UGA5" /coded_by="NM_001178354.1:1..1494" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006540 gamma-aminobutyrate shunt [PMID:11031268]" /experiment="EXISTENCE:mutant phenotype:GO:0006540 gamma-aminobutyrate shunt [PMID:11031268]" /experiment="EXISTENCE:mutant phenotype:GO:0009013 succinate-semialdehyde dehydrogenase [NAD(P)+] activity [PMID:11031268|PMID:3888627]" /experiment="EXISTENCE:mutant phenotype:GO:0009450 gamma-aminobutyric acid catabolic process [PMID:11031268|PMID:3888627]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11031268]" /note="Succinate semialdehyde dehydrogenase; involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm" /db_xref="GeneID:852291" /db_xref="SGD:S000000210" ORIGIN 1 mtlskyskpt lndpnlfres gyidgkwvkg tdevfevvdp asgeiiarvp eqpvsvveea 61 idvayetfkt yknttprera kwlrnmynlm lenlddlati itlengkalg eakgeikyaa 121 syfewyaeea prlygatiqp lnphnrvfti rqpvgvcgii cpwnfpsami trkaaaalav 181 gctvvikpds qtplsalama ylaekagfpk gsfnvilsha ntpklgktlc espkvkkvtf 241 tgstnvgkil mkqssstlkk lsfelggnap fivfedadld qaleqamack frglgqtcvc 301 anrlyvhssi idkfakllae rvkkfvighg ldpktthgcv inssaiekve rhkqdaidkg 361 akvvleggrl telgpnfyap vilshvpsta ivskeetfgp lcpifsfdtm eevvgyandt 421 efglaayvfs knvntlytvs ealetgmvsc ntgvfsdcsi pfggvkesgf gregslygie 481 dytvlktiti gnlpnsi // LOCUS NP_009561 736 aa linear PLN 30-JUN-2025 DEFINITION Dsf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009561 VERSION NP_009561.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178355.2 REFERENCE 1 (residues 1 to 736) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 736) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 736) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 736) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 736) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 736) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 736) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07128. On Apr 26, 2011 this sequence version replaced NP_009561.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..736 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..736 /product="Dsf2p" /calculated_mol_wt="82205" Region 562..591 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region <563..716 /region_name="TPR" /note="TPR repeat [General function prediction only]; COG0790" /db_xref="CDD:440553" Region 598..656 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 664..693 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" CDS 1..736 /gene="DSF2" /locus_tag="YBR007C" /coded_by="NM_001178355.2:1..2211" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /note="Deletion suppressor of mpt5 mutation; relocalizes from bud neck to cytoplasm upon DNA replication stress" /db_xref="GeneID:852292" /db_xref="SGD:S000000211" ORIGIN 1 mnqnlkntsw adrigsddqe rkanssevsq spppnnsfes smdsqfsyah snkssisfes 61 iqtterlldk ldlsledeli lqealleeen asrnsqlsqt sgptlcmpas efpslryrtn 121 psptyiqard rsliidnlke kdstlrgkys sgkverhlpv ksrysyivee dydsetfsgm 181 kpqmnrnekd ykypnlengn rstnspnpfn fekyrientr lhhlyptlis dnntsvdnna 241 nsknnrttsn nintstktdr isekqscpne ftttqksncl yrngsststn tsfsevgqls 301 kpktqssfes esssfsklkl tksdttpikp spkrsnssts titktntmtn dislpptppy 361 kahkkktsln slkklfkspr traknkkdle segsspirsa tnsldfsgen iqlpstssti 421 nnssphlary ifppnpvfhf ktastpqsst dkkknskarp nrthlrtfsd fhttekdski 481 gelsalteqs nkpyhpkvrr rtlsldgmlp nnstqcmdsf shkkegsnat skcgklkfhp 541 epydndessh igqaitmrhq gkleesaqrl kkacacgnkt afllyglalr hgcgvdknlk 601 lslgylmaat diksfaaevl dldinplnfa smddipdiap eptapalyec gmaylkglgm 661 dhpderkglk flekaallgh vdsmclsgti wsktsnvkkr dlaraaawfr iadkkganll 721 gsdwiykeky mkqgpk // LOCUS NP_009562 548 aa linear PLN 30-JUN-2025 DEFINITION Flr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009562 VERSION NP_009562.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178356.1 REFERENCE 1 (residues 1 to 548) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 548) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 548) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 548) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07129. Method: conceptual translation. FEATURES Location/Qualifiers source 1..548 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..548 /product="Flr1p" /calculated_mol_wt="61498" Region 106..540 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(116..117,120..121,124,156,208..209,211..213,216,236, 239..240,243,347,350..351,354..356,359,383,387,455..456, 460,464,479,482..483,486..487,490) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..548 /gene="FLR1" /locus_tag="YBR008C" /coded_by="NM_001178356.1:1..1647" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10903515]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane [PMID:10572257|PMID:9235926]" /experiment="EXISTENCE:mutant phenotype:GO:0015244 fluconazole transmembrane transporter activity [PMID:9235926]" /experiment="EXISTENCE:mutant phenotype:GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane [PMID:10572257]" /note="Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin; relocalizes from nucleus to plasma membrane upon DNA replication stress" /db_xref="GeneID:852293" /db_xref="SGD:S000000212" ORIGIN 1 mvytstyrht ivvdlleylg ivsnletlqs aredetrkpe ntdkkeckpd ydiecgpnrs 61 csesstdsds sgsqiekndp frvdwngpsd penpqnwpll kkslvvfqim lltcvtymgs 121 siytpgqeyi qeefhvghvv atlnlslyvl gyglgpiifs plsetarygr lnlymvtlff 181 fmifqvgcat vhnigglivm rfisgilcsp slatgggtva diispemvpl vlgmwsagav 241 aapvlapllg aamvdaknwr fifwllmwls aatfillaff fpetqhhnil yrralklrke 301 tgddryyteq dkldrevdar tflintlyrp lkmiikepai lafdlyiava ygcfylffea 361 fpivfvgiyh fslvevglay mgfcvgcvla yglfgilnmr iivprfrngt ftpeafliva 421 mcvcwclpls lflfgwtarv hwilpvisev ffvlavfnif qatfaylatc ypkyvasvfa 481 gngfcrasfa cafplfgram ydnlatknyp vawgsslvgf ltlglaiipf ilykygpslr 541 trssytee // LOCUS NP_009563 103 aa linear PLN 30-JUN-2025 DEFINITION histone H4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009563 VERSION NP_009563.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178357.1 REFERENCE 1 (residues 1 to 103) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 103) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 103) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 103) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07130. Method: conceptual translation. FEATURES Location/Qualifiers source 1..103 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..103 /product="histone H4" /calculated_mol_wt="11237" Region 18..101 /region_name="PTZ00015" /note="histone H4; Provisional" /db_xref="CDD:185397" CDS 1..103 /gene="HHF1" /locus_tag="YBR009C" /coded_by="NM_001178357.1:1..312" /note="Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; involved in mRNA multiplexing; N-terminal domain involved in maintaining genomic integrity" /db_xref="GeneID:852294" /db_xref="SGD:S000000213" ORIGIN 1 msgrgkggkg lgkggakrhr kilrdniqgi tkpairrlar rggvkrisgl iyeevravlk 61 sflesvirds vtytehakrk tvtsldvvya lkrqgrtlyg fgg // LOCUS NP_009564 136 aa linear PLN 30-JUN-2025 DEFINITION histone H3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009564 VERSION NP_009564.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178358.1 REFERENCE 1 (residues 1 to 136) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 136) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 136) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 136) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07131. Method: conceptual translation. FEATURES Location/Qualifiers source 1..136 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..136 /product="histone H3" /calculated_mol_wt="15225" Region 1..136 /region_name="PTZ00018" /note="histone H3; Provisional" /db_xref="CDD:185400" Site order(40..48,50,64..67,70,73,84..87,117..119,121) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:467036" Site order(45,48,51..52,55..56,58,60,62..63,67..68,70..72, 74..75,77,79,82..86,88..89,92..93,96..98,100..102,104..106, 109,118..122,126,129) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467036" Site order(49,52..53,56..57,59,95,99,102,109,113,118) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467036" Site order(107,110..111,114..115,117,123..124,127..128,130..132) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:467036" CDS 1..136 /gene="HHT1" /locus_tag="YBR010W" /gene_synonym="BUR5; SIN2" /coded_by="NM_001178358.1:1..411" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0008823 cupric reductase (NADH) activity [PMID:32631887]" /experiment="EXISTENCE:direct assay:GO:0043505 CENP-A containing nucleosome [PMID:22693454]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:32631887]" /experiment="EXISTENCE:mutant phenotype:GO:0008823 cupric reductase (NADH) activity [PMID:32631887]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:32631887]" /experiment="EXISTENCE:mutant phenotype:GO:0009303 rRNA transcription [PMID:16002464]" /experiment="EXISTENCE:mutant phenotype:GO:0043935 sexual sporulation resulting in formation of a cellular spore [PMID:20713519]" /experiment="EXISTENCE:mutant phenotype:GO:0070911 global genome nucleotide-excision repair [PMID:21460225]" /note="Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage" /db_xref="GeneID:852295" /db_xref="SGD:S000000214" ORIGIN 1 martkqtark stggkaprkq laskaarksa pstggvkkph rykpgtvalr eirrfqkste 61 llirklpfqr lvreiaqdfk tdlrfqssai galqesveay lvslfedtnl aaihakrvti 121 qkkdiklarr lrgers // LOCUS NP_009565 287 aa linear PLN 30-JUN-2025 DEFINITION inorganic diphosphatase IPP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009565 VERSION NP_009565.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178359.1 REFERENCE 1 (residues 1 to 287) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 287) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 287) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 287) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07132. Method: conceptual translation. FEATURES Location/Qualifiers source 1..287 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..287 /product="inorganic diphosphatase IPP1" /EC_number="3.6.1.1" /calculated_mol_wt="32169" Region 3..239 /region_name="pyrophosphatase" /note="Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; cl00217" /db_xref="CDD:469666" Site order(52..53,128..129) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238239" Site order(57,79,94,193..194) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238239" Site order(59,116,121,148,153) /site_type="metal-binding" /note="metal binding sites [ion binding]" /db_xref="CDD:238239" CDS 1..287 /gene="IPP1" /locus_tag="YBR011C" /gene_synonym="PPA1" /coded_by="NM_001178359.1:1..864" /experiment="EXISTENCE:curator inference:GO:0006796 phosphate-containing compound metabolic process [PMID:8224193]" /experiment="EXISTENCE:direct assay:GO:0004427 inorganic diphosphate phosphatase activity [PMID:8224193]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic inorganic pyrophosphatase (PPase); homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase" /db_xref="GeneID:852296" /db_xref="SGD:S000000215" ORIGIN 1 mtyttrqiga kntleykvyi ekdgkpvsaf hdiplyadke nnifnmvvei prwtnaklei 61 tkeetlnpii qdtkkgklrf vrncfphhgy ihnygafpqt wedpnvshpe tkavgdndpi 121 dvleigetia ytgqvkqvka lgimalldeg etdwkviaid indplapkln diedvekyfp 181 gllratnewf riykipdgkp enqfafsgea knkkyaldii kethdswkql iagkssdskg 241 idltnvtlpd tptyskaasd aippaspkad apidksidkw ffisgsv // LOCUS NP_009568 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009568 VERSION NP_009568.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180055.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 440) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07134. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..440 /product="gag protein" /calculated_mol_wt="48937" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YBR012W-A" /coded_by="NM_001180055.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:852298" /db_xref="SGD:S000002154" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr pitddeltfl ynafqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_009567 1756 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009567 VERSION NP_009567.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180056.2 REFERENCE 1 (residues 1 to 1756) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1756) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1756) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1756) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1756) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1756) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1756) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07133. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1756 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1756 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198739" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1266..1499 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1607..1743 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1611..1614,1648..1650,1653,1686,1713,1740) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1756 /locus_tag="YBR012W-B" /coded_by="join(NM_001180056.2:1..1305, NM_001180056.2:1307..5272)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:852299" /db_xref="SGD:S000002155" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr pitddeltfl ynafqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktslkvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkdsrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsn dlniesdhdf qsdielypeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis diestdsggm 1021 hrldvpllap msqsnthess yaskskdfrh sdsysdnetn htnvpisstg gtnnktvpqt 1081 seqetekrii hrftsdrilp ssesnslhhv vpiktsdtcf kenteesiia dlplpdlppe 1141 pptelsdsfk elppinsrqt nsslggigds nayttinskk rslednetei kvsrdtwntk 1201 nmrslepprs kkrihliaav kavksikpir ttlrydeait ynkdikekek yieayhkevn 1261 qllkmktwdt dkyydrkeid pkrvinsmfi fnrkrdgthk arfvargdiq hpdtydsgmq 1321 sntvhhyalm tslslaldnn yyitqldiss aylyadikee lyirppphlg mndklirlkk 1381 slyglkqsga nwyetiksyl ikqcgmeevr gwscvfknsq vticlfvddm ilfskdlnsn 1441 kriiaklkmq ydtkiinlge sddeiqhdil gleikyqrgk ymklgmensl tekipklnvp 1501 lnpngrklga pgqpglyinq qeleleeddy kmkvhemqkl iglasyvgyk frfdllyyin 1561 tlaqhilfps kqvldmtyel iqfiwntrdk qliwhkskpv kptnklvvis dasygnqpyy 1621 ksqigniyll ngkviggkst kasltctstt eaeihaises vpllnnlsyl iqeldkkpit 1681 kglltdskst isiiisnnee kfrnrffgtk amrlrdevsg nhlhvcyiet kkniadvmtk 1741 plpiktfkll tnkwih // LOCUS NP_009569 129 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR013C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009569 VERSION NP_009569.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178361.1 REFERENCE 1 (residues 1 to 129) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 129) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 129) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 129) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07135. Method: conceptual translation. FEATURES Location/Qualifiers source 1..129 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..129 /product="uncharacterized protein" /calculated_mol_wt="14350" CDS 1..129 /locus_tag="YBR013C" /coded_by="NM_001178361.1:1..390" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein; SWAT-GFP fusion protein localizes to the endoplasmic reticulum while mCherry fusion protein localizes to both the endoplasmic reticulum and vacuole" /db_xref="GeneID:852300" /db_xref="SGD:S000000217" ORIGIN 1 miyplfrici lgafllgsya clenstqkgi egvtlshnsv qinntlaksa pfcesdalsm 61 nystenmlsn nacdytknss ypyiitiitk afdnalensl nlqanrklyh rvgtciqnif 121 yqllltvny // LOCUS NP_009570 203 aa linear PLN 30-JUN-2025 DEFINITION glutathione-disulfide reductase GRX7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009570 VERSION NP_009570.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178362.1 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 203) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07136. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..203 /product="glutathione-disulfide reductase GRX7" /calculated_mol_wt="22434" Region 99..181 /region_name="GRX_GRXh_1_2_like" /note="Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase; cd03419" /db_xref="CDD:239511" Site order(105,108,110,153..156,167..170) /site_type="other" /note="GSH binding site [chemical binding]" /db_xref="CDD:239511" Site order(108,111) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239511" CDS 1..203 /gene="GRX7" /locus_tag="YBR014C" /coded_by="NM_001178362.1:1..612" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0004362 glutathione-disulfide reductase (NADPH) activity [PMID:18400945]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:18503006]" /experiment="EXISTENCE:direct assay:GO:0005796 Golgi lumen [PMID:18400945]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:18400945]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:18503006]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:18400945]" /note="Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication" /db_xref="GeneID:852302" /db_xref="SGD:S000000218" ORIGIN 1 maivinkrnv rvlvitnlll ivvffvlrns nasvnesitt hhpdslvtfd nsgnapgthq 61 svhdtvntqd keaeevdkns gdaefdaaae ynkimeqspm ivfsktgcpy skklkalltn 121 sytfspsyyv veldrhehtk elqdqiekvt grrtvpnvii ggtsrggyte iaelhkndel 181 ldsfkkwsdg aftvkansqs esa // LOCUS NP_009571 597 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,2-mannosyltransferase MNN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009571 VERSION NP_009571.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178363.1 REFERENCE 1 (residues 1 to 597) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 597) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 597) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 597) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 597) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 597) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 597) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07137. Method: conceptual translation. FEATURES Location/Qualifiers source 1..597 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..597 /product="alpha-1,2-mannosyltransferase MNN2" /calculated_mol_wt="67643" Region 170..440 /region_name="Mannosyl_trans3" /note="Mannosyltransferase putative; pfam11051" /db_xref="CDD:402574" CDS 1..597 /gene="MNN2" /locus_tag="YBR015C" /gene_synonym="CRV4; LDB8; TTP1" /coded_by="NM_001178363.1:1..1794" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:9756928]" /experiment="EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:9756928]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:9756928]" /note="Alpha-1,2-mannosyltransferase; responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment" /db_xref="GeneID:852303" /db_xref="SGD:S000000219" ORIGIN 1 mlltkrfskl fkltfivlil cglfvitnky mdentsvkey keyldryvqs ysnkyssssd 61 aasaddstpl rdndeagnek lksfynnvfn flmvdspkgs takqyneacl lkgdigdrpd 121 hykdlyklsa kelskclels pdevasltks hkdyvehiat lvspkgtykg sgiatvgggk 181 fslmafliik tlrnmgttlp vevlippgde getefcnkil pkynskciyv sdilpretie 241 kfvfkgyqfk slaliassfe nlllldadnf pikpldnifn eepyvstglv mwpdfwrrtt 301 hplyydiagi avdkkkrvrn srdditppav ytkdlkdlsd vplsdldgti pdvstesgql 361 minktkhlat allslfynvn gptwyypifs qkaagegdke tfiaaanfyg lsfyqvrtrt 421 gvegyhdedg fhgvamlqhd fvqdygryln amesignkyg gtksadaikf dknyslekyt 481 eeffdnedln aknhvdvmfi hsnfpkfdpy dlsksnfltt ngkparsyta lkkvknydie 541 lenfkvlney vcvnknpfky lddllgqdkt ewkrvcgyit drlaflesth dkaiagk // LOCUS NP_009572 128 aa linear PLN 30-JUN-2025 DEFINITION cysteine-rich palmitoylated domain-containing protein CPP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009572 VERSION NP_009572.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178364.1 REFERENCE 1 (residues 1 to 128) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 128) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 128) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 128) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07138. Method: conceptual translation. FEATURES Location/Qualifiers source 1..128 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..128 /product="cysteine-rich palmitoylated domain-containing protein CPP1" /calculated_mol_wt="14486" CDS 1..128 /gene="CPP1" /locus_tag="YBR016W" /coded_by="NM_001178364.1:1..387" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:38159851|PMID:12514182]" /experiment="EXISTENCE:direct assay:GO:0033101 cellular bud membrane [PMID:12514182]" /experiment="EXISTENCE:direct assay:GO:0070250 mating projection membrane [PMID:12514182]" /note="Tail-anchored plasma membrane (PM) protein; C-terminal palmitoylation is required for membrane anchoring and protein stability; PM localization is polarized to the daughter cell; contains a conserved, cysteine-rich palmitoylated domain (CYSPD, aka CYSTM); similarity to hydrophilins, proteins involved in the adaptive response to hyperosmotic conditions; CPP1 has a paralog, YDL012C, that arose from the whole genome duplication" /db_xref="GeneID:852304" /db_xref="SGD:S000000220" ORIGIN 1 msandyyggt ageksqysrp snpppssahq nktqergypp qqqqqyyqqq qqhpgyynqq 61 gynqqgynqq gynqqgynqq gynqqgynqq ghqqpvyvqq qppqrgnegc laaclaalci 121 cctmdmlf // LOCUS NP_009573 918 aa linear PLN 30-JUN-2025 DEFINITION Kap104p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009573 VERSION NP_009573.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178365.1 REFERENCE 1 (residues 1 to 918) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 918) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 918) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 918) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07139. Method: conceptual translation. FEATURES Location/Qualifiers source 1..918 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..918 /product="Kap104p" /calculated_mol_wt="103551" Region 191..225 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 234..261 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 272..301 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(401..402,405,408..409,439..440,443,446..447,450, 480..481,484,487..488,491,521..522,525,528..529) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 422..542 /region_name="HEAT" /note="HEAT repeat [General function prediction only]; COG1413" /db_xref="CDD:441023" Region 422..450 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 435..489 /region_name="HEAT_EZ" /note="HEAT-like repeat; pfam13513" /db_xref="CDD:463906" Region 462..492 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 500..529 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 546..572 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..918 /gene="KAP104" /locus_tag="YBR017C" /coded_by="NM_001178365.1:1..2757" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8849456]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:19198597]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:19198597]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:8849456|PMID:19366694|PMID:9488461]" /experiment="EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:9488461]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:8849456|PMID:19366694]" /experiment="EXISTENCE:mutant phenotype:GO:0010458 exit from mitosis [PMID:12524331]" /note="Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis" /db_xref="GeneID:852305" /db_xref="SGD:S000000221" ORIGIN 1 mastwkpaed yvlqlatllq ncmspnpeir nnameamenf qlqpeflnyl cyiliegesd 61 dvlkqhyslq dlqnnratag mllknsmlgg nnliksnshd lgyvksniih glynsnnnlv 121 snvtgivitt lfstyyrqhr ddptglqmly qlleltsngn epsikalski medsaqffql 181 ewsgntkpme alldsffrfi snpnfspvir sesvkcintv iplqtqsfiv rldkfleiif 241 qlaqndendl vraqicisfs fllefrpdkl vshldgivqf mlhlittvne ekvaieacef 301 lhafatspni pehilqpyvk divpillskm vyneesivll easndddafl edkdedikpi 361 aprivkkkea gngedaddne dddddddded gdvdtqwnlr kcsaatldvm tnilphqvmd 421 iafpflrehl gsdrwfirea tilalgamae ggmkyfndgl palipflveq lndkwapvrk 481 mtcwtlsrfs pwilqdhtef lipvlepiin tlmdkkkdvq eaaissvavf ienadselve 541 tlfysqllts fdkclkyykk knliilydai grfaekcald etamqiilpp liekwallsd 601 sdkelwplle clscvasslg erfmpmapev ynrafrilch cveleakshq dptivvpekd 661 fiitsldlid glvqglgahs qdllfpqgtk dltilkimle clqdpvhevr qscfallgdi 721 vyffnselvi gnledflkli gteimhndds dgtpavinai walgliseri dlntyiidms 781 riildlfttn tqivdssvme nlsvtigkmg lthpevfssg afandsnwnk wclsvnaldd 841 veekssaymg flkiinltst evtmsndtih kivtglssnv eanvfaqeiy tflmnhsaqi 901 sainftpdei sflqqfts // LOCUS NP_009574 366 aa linear PLN 30-JUN-2025 DEFINITION UDP-glucose:hexose-1-phosphate uridylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009574 VERSION NP_009574.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178366.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 366) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07140. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..366 /product="UDP-glucose:hexose-1-phosphate uridylyltransferase" /EC_number="2.7.7.12" /calculated_mol_wt="42254" Region 3..366 /region_name="galT_1" /note="galactose-1-phosphate uridylyltransferase, family 1; TIGR00209" /db_xref="CDD:129313" CDS 1..366 /gene="GAL7" /locus_tag="YBR018C" /coded_by="NM_001178366.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10993714]" /experiment="EXISTENCE:direct assay:GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity [PMID:387754]" /experiment="EXISTENCE:direct assay:GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway [PMID:387754]" /experiment="EXISTENCE:mutant phenotype:GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity [PMID:14158615]" /experiment="EXISTENCE:mutant phenotype:GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway [PMID:14158615]" /note="Galactose-1-phosphate uridyl transferase; synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism; human homolog UGP2 can complement yeast null mutant" /db_xref="GeneID:852306" /db_xref="SGD:S000000222" ORIGIN 1 mtaeefdfss hshrrynplt dswilvsphr akrpwlgqqe aaykptaply dpkcylcpgn 61 kratgnlnpr yestyifpnd yaavrldqpi lpqndsnedn lknrllkvqs vrgncfvicf 121 spnhnltipq mkqsdlvhiv nswqaltddl srearenhkp fkyvqifenk gtamgcsnlh 181 phgqawcles ipsevsqelk sfdkykrehn tdlfadyvkl esreksrvvv enesfivvvp 241 ywaiwpfetl viskkklasi sqfnqmvked lasilkqlti kydnlfetsf pysmgihqap 301 lnatgdelsn swfhmhfypp llrsatvrkf lvgfellgep qrdltseqaa eklrnldgqi 361 hylqrl // LOCUS NP_009575 699 aa linear PLN 30-JUN-2025 DEFINITION bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009575 VERSION NP_009575.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178367.1 REFERENCE 1 (residues 1 to 699) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 699) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 699) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 699) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07141. Method: conceptual translation. FEATURES Location/Qualifiers source 1..699 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..699 /product="bifunctional UDP-glucose 4-epimerase/aldose 1-epimerase" /EC_number="5.1.3.2" /EC_number="5.1.3.3" /calculated_mol_wt="78064" Region 14..349 /region_name="UDP_G4E_1_SDR_e" /note="UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; cd05247" /db_xref="CDD:187558" Site order(18,20..23,42..47,68..70,91..93,95,110,133..135,163, 167,192..193,195) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:187558" Site order(101,103..105,108..109,112..113,116..117,119..120,123, 162,165,169,172..173,175..177) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:187558" Site order(111,135,163,167) /site_type="active" /db_xref="CDD:187558" Site order(135..137,163,192..194,213..215,230..233,244,246,248, 288,311,314) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:187558" Region 376..698 /region_name="galactose_mutarotase_like" /note="galactose mutarotase_like; cd09019" /db_xref="CDD:185696" Site order(422,433,458,537,539,599,647,665) /site_type="active" /db_xref="CDD:185696" Site order(537,665) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:185696" CDS 1..699 /gene="GAL10" /locus_tag="YBR019C" /coded_by="NM_001178367.1:1..2100" /experiment="EXISTENCE:direct assay:GO:0003978 UDP-glucose 4-epimerase activity [PMID:14764091]" /experiment="EXISTENCE:direct assay:GO:0004034 aldose 1-epimerase activity [PMID:14764091]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:14764091]" /experiment="EXISTENCE:direct assay:GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway [PMID:14764091]" /experiment="EXISTENCE:mutant phenotype:GO:0003978 UDP-glucose 4-epimerase activity [PMID:14158615]" /experiment="EXISTENCE:mutant phenotype:GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway [PMID:14158615]" /note="UDP-glucose-4-epimerase; catalyzes interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers; human homolog GALE implicated in galactosemia, can complement yeast null mutant" /db_xref="GeneID:852307" /db_xref="SGD:S000000223" ORIGIN 1 mtaqlqsest skivlvtgga gyigshtvve liengydcvv adnlsnstyd svarlevltk 61 hhipfyevdl cdrkglekvf keykidsvih faglkavges tqiplryyhn nilgtvvlle 121 lmqqynvskf vfsssatvyg datrfpnmip ipeecplgpt npyghtkyai enilndlyns 181 dkkswkfail ryfnpigahp sgligedplg ipnnllpyma qvavgrrekl yifgddydsr 241 dgtpirdyih vvdlakghia alqyleayne neglcrewnl gsgkgstvfe vyhafckasg 301 idlpykvtgr ragdvlnlta kpdrakrelk wqtelqveds ckdlwkwtte npfgyqlrgv 361 earfsaedmr ydarfvtiga gtrfqatfan lgasivdlkv ngqsvvlgye neegylnpds 421 ayigatigry anriskgkfs lcnkdyqltv nngvnanhss igsfhrkrfl gpiiqnpskd 481 vftaeymlid nekdtefpgd llvtiqytvn vaqkslemvy kgkltageat pinltnhsyf 541 nlnkpygdti egteimvrsk ksvdvdknmi ptgnivdrei atfnstkptv lgpknpqfdc 601 cfvvdenakp sqintlnnel tlivkafhpd snitlevlst eptyqfytgd flsagyearq 661 gfaiepgryi dainqenwkd cvtlkngety gskivyrfs // LOCUS NP_009576 528 aa linear PLN 30-JUN-2025 DEFINITION galactokinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009576 VERSION NP_009576.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178368.1 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 528) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07142. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..528 /product="galactokinase" /EC_number="2.7.1.6" /calculated_mol_wt="57813" Region 29..524 /region_name="gal_kin" /note="galactokinase; TIGR00131" /db_xref="CDD:272924" CDS 1..528 /gene="GAL1" /locus_tag="YBR020W" /coded_by="NM_001178368.1:1..1587" /experiment="EXISTENCE:direct assay:GO:0004335 galactokinase activity [PMID:14144]" /experiment="EXISTENCE:direct assay:GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway [PMID:14144]" /experiment="EXISTENCE:direct assay:GO:0046835 carbohydrate phosphorylation [PMID:14144]" /experiment="EXISTENCE:genetic interaction:GO:0000411 positive regulation of transcription by galactose [PMID:2199310]" /experiment="EXISTENCE:genetic interaction:GO:0005737 cytoplasm [PMID:2199310]" /experiment="EXISTENCE:mutant phenotype:GO:0004335 galactokinase activity [PMID:13495476]" /experiment="EXISTENCE:mutant phenotype:GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway [PMID:13495476]" /note="Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; human homolog GALK2 complements yeast null mutant; GAL1 has a paralog, GAL3, that arose from the whole genome duplication" /db_xref="GeneID:852308" /db_xref="SGD:S000000224" ORIGIN 1 mtkshseevi vpefnssake lprplaekcp siikkfisay dakpdfvars pgrvnligeh 61 idycdfsvlp laidfdmlca vkvlneknps itlinadpkf aqrkfdlpld gsyvtidpsv 121 sdwsnyfkcg lhvahsflkk laperfasap laglqvfceg dvptgsglss saaficaval 181 avvkanmgpg yhmskqnlmr itvvaehyvg vnnggmdqaa svcgeedhal yvefkpqlka 241 tpfkfpqlkn heisfviant lvvsnkfeta ptnynlrvve vttaanvlaa tygvvllsgk 301 egsstnkgnl rdfmnvyyar yhnistpwng diesgierlt kmlvlveesl ankkqgfsvd 361 dvaqslncsr eeftrdyltt spvrfqvlkl yqrakhvyse slrvlkavkl mttasftade 421 dffkqfgalm nesqascdkl yecscpeidk icsialsngs ygsrltgagw ggctvhlvpg 481 gpngniekvk ealanefykv kypkitdael enaiivskpa lgsclyel // LOCUS NP_009577 633 aa linear PLN 30-JUN-2025 DEFINITION uracil permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_009577 VERSION NP_009577.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178369.1 REFERENCE 1 (residues 1 to 633) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 633) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 633) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 633) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07143. Method: conceptual translation. FEATURES Location/Qualifiers source 1..633 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..633 /product="uracil permease" /calculated_mol_wt="71605" Region 96..580 /region_name="SLC-NCS1sbd_NRT1-like" /note="nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain; cd11482" /db_xref="CDD:271375" Site order(122,125,412,415..416) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271375" Site order(126,202,206,324..325,327,417,421) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:271375" CDS 1..633 /gene="FUR4" /locus_tag="YBR021W" /coded_by="NM_001178369.1:1..1902" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8948441]" /experiment="EXISTENCE:direct assay:GO:0015505 uracil:monoatomic cation symporter activity [PMID:8948441]" /experiment="EXISTENCE:direct assay:GO:0015857 uracil transport [PMID:8948441]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:15536122]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:8948441]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Plasma membrane localized uracil permease; expression is tightly regulated by uracil levels and environmental cues; conformational alterations induced by unfolding or substrate binding result in Rsp5p-mediated ubiquitination and degradation" /db_xref="GeneID:852309" /db_xref="SGD:S000000225" ORIGIN 1 mpdnlslhls gsskrlnsrq lmessnetfa pnnvdlekey kssqsnitte vyeassfeek 61 vssekpqyss fwkkiyyeyv vvdksilgvs ildsfmynqd lkpvekerrv wswynycyfw 121 laecfnintw qiaatglqlg lnwwqcwiti wigygfvgaf vvlasrvgsa yhlsfpissr 181 asfgiffslw pvinrvvmai vwysvqayia atpvslmlks ifgkdlqdki pdhfgspnat 241 tyefmcffif waaslpfllv pphkirhlft vkavlvpfas fgfliwairr ahgrialgsl 301 tdvqphgsaf swaflrslmg cmanfstmvi napdfsrfsk npnsalwsql vcipflfsit 361 cligilvtaa gyeiyginyw spldvlekfl qttynkgtra gvflisfvfa vaqlgtnisa 421 nslscgtdms aifpkfinik rgslfcaama lcicpwnlma tsskftmals ayaiflssia 481 gvvcsdyfvv rrgyiklthi yshqkgsfym ygnrfginwr alaaylcgva pclpgfiaev 541 gapaikvsdg amklyylsyw vgyglsfssy talcyffpvp gcpvnniikd kgwfqrwanv 601 ddfeeewkdt ierddlvddn isvyehehek tfi // LOCUS NP_009578 177 aa linear PLN 30-JUN-2025 DEFINITION ADP-ribose 1''-phosphate phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009578 VERSION NP_009578.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178370.1 REFERENCE 1 (residues 1 to 177) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 177) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 177) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 177) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07144. Method: conceptual translation. FEATURES Location/Qualifiers source 1..177 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..177 /product="ADP-ribose 1''-phosphate phosphatase" /EC_number="3.1.3.84" /calculated_mol_wt="19807" Region 3..170 /region_name="Macro_Poa1p-like" /note="macrodomain, Poa1p-like family; cd02901" /db_xref="CDD:394873" Site order(9..12,23..26,30..36,38,83..84,145..152) /site_type="other" /note="ADP-ribose binding site [chemical binding]" /db_xref="CDD:394873" CDS 1..177 /gene="POA1" /locus_tag="YBR022W" /coded_by="NM_001178370.1:1..534" /experiment="EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:15684411|PMID:10550052]" /experiment="EXISTENCE:direct assay:GO:0047407 ADP-ribosyl-[dinitrogen reductase] hydrolase activity [PMID:23474712]" /note="Phosphatase that is highly specific for ADP-ribose 1''-phosphate; a tRNA splicing metabolite; may have a role in regulation of tRNA splicing" /db_xref="GeneID:852310" /db_xref="SGD:S000000226" ORIGIN 1 msnityvkgn ilkpksyari lihscncngs wgggiayqla lrypkaekdy vevcekygsn 61 llgkcillps yensdllicc lftssfggss hgekqsilny tklaldklkt freakdktrt 121 sedsigdyln ghikypigey klempqinsg ifgvpwkete rvleefsgdm sftvyql // LOCUS NP_009579 1165 aa linear PLN 30-JUN-2025 DEFINITION chitin synthase CHS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009579 VERSION NP_009579.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178371.1 REFERENCE 1 (residues 1 to 1165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1165) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07145. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1165 /product="chitin synthase CHS3" /EC_number="2.4.1.16" /calculated_mol_wt="131471" Region 628..1151 /region_name="Chitin_synth_2" /note="Chitin synthase; pfam03142" /db_xref="CDD:367353" CDS 1..1165 /gene="CHS3" /locus_tag="YBR023C" /gene_synonym="CAL1; CSD2; DIT101; KTI2" /coded_by="NM_001178371.1:1..3498" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9008706|PMID:8909536|PMID:15470103]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:15755916]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9008706]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15470103|PMID:8909536]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0045009 chitosome [PMID:8970154]" /experiment="EXISTENCE:mutant phenotype:GO:0004100 chitin synthase activity [PMID:9760183]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:3280554]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:1293886]" /experiment="EXISTENCE:mutant phenotype:GO:0097271 protein localization to bud neck [PMID:29405545]" /note="Chitin synthase III; catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan; contains overlapping di-leucine and di-acidic signals that mediate, respectively, intracellular trafficking by AP-1 and trafficking to plasma membrane by exomer complex; requires AP-3 complex for its intracellular retention" /db_xref="GeneID:852311" /db_xref="SGD:S000000227" ORIGIN 1 mtglngddpd dyylnlnqde esllrsrhsv gsgaphrqgs lvrpersrln npdnphfyya 61 qktqeqmnhl dvlpsstgvn pnatrrsgsl rskgsvrskf sgretdsyll qdmnttdkka 121 svkisdegva edefdkdgdv dnfeesstqp inksikplrk etndtlsfwq mycyfitfwa 181 papilafcgm pkkerqmawr ekvalisvil yigaivaflt fgftktvcss sklrlknnev 241 stefvvingk ayeldtssrs giqdvevdsd tlygpwsdag kdasflfqnv ngnchnlitp 301 ksnssiphdd dnnlawyfpc klknqdgssk pnftvenyag wnchtskedr dafyglkska 361 dvyftwdgik nssrnlivyn gdvldldlld wlekddvdyp vvfddlktsn lqgydlslvl 421 sngherkiar clseiikvge vdsktvgcia sdvvlyvslv filsvviikf iiacyfrwtv 481 arkqgayivd nktmdkhtnd iedwsnniqt kaplkevdph lrpkkyskks lghkrastfd 541 llkkhsskmf qfnesvidld tsmssslqss gsyrgmttmt tqnawklsne nkavhsrnps 601 tllptssmfw nkatsspvpg ssliqsldst iihpdivqqp pldfmpygfp lihticfvtc 661 ysedeeglrt tldslsttdy pnshkllmvv cdglikgsgn dkttpeialg mmddfvtppd 721 evkpysyvav asgskrhnma kiyagfykyd dstippenqq rvpiitivkc gtpaeqgaak 781 pgnrgkrdsq iilmsfleki tfdermtqle fqllkniwqi tglmadfyet vlmvdadtkv 841 fpdalthmva emvkdplimg lcgetkiank aqswvtaiqv feyyishhqa kafesvfgsv 901 tclpgcfsmy rikspkgsdg ywvpvlanpd iverysdnvt ntlhkknlll lgedrflssl 961 mlktfpkrkq vfvpkaackt iapdkfkvll sqrrrwinst vhnlfelvli rdlcgtfcfs 1021 mqfvigieli gtmvlplaic ftiyviifai vskptpvitl vllaiilglp glivvitatr 1081 wsylwwmcvy icalpiwnfv lpsyaywkfd dfswgdtrti aggnkkaqde negefdhski 1141 kmrtwrefer edilnrkees dsfva // LOCUS NP_009580 301 aa linear PLN 30-JUN-2025 DEFINITION putative thioredoxin peroxidase SCO2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009580 VERSION NP_009580.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178372.1 REFERENCE 1 (residues 1 to 301) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 301) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 301) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 301) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07146. Method: conceptual translation. FEATURES Location/Qualifiers source 1..301 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..301 /product="putative thioredoxin peroxidase SCO2" /calculated_mol_wt="34757" Region 121..263 /region_name="SCO" /note="SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; cd02968" /db_xref="CDD:239266" Site order(154,158,245) /site_type="other" /note="Cu(I) binding site [ion binding]" /db_xref="CDD:239266" CDS 1..301 /gene="SCO2" /locus_tag="YBR024W" /coded_by="NM_001178372.1:1..906" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:25959673]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:8702795]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:30593977]" /experiment="EXISTENCE:genetic interaction:GO:0045454 cell redox homeostasis [PMID:30593977]" /note="Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication" /db_xref="GeneID:852312" /db_xref="SGD:S000000228" ORIGIN 1 mlnssrkyac rslfrqanvs ikglfyngga yrrgfstgcc lrsdnkesps arqpldrlql 61 gdeinepepi rtrffqfsrw katialllls ggtyaylsrk rrlletekea danraygsva 121 lggpfnltdf ngkpfteenl kgkfsilyfg fshcpdicpe eldrltywis elddkdhiki 181 qplfiscdpa rdtpdvlkey lsdfhpaiig ltgtydqvks vckkykvyfs tprdvkpnqd 241 ylvdhsiffy lidpegqfid algrnydeqs glekireqiq ayvpkeerer rskkwysfif 301 n // LOCUS NP_009581 394 aa linear PLN 30-JUN-2025 DEFINITION Obg-like ATPase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009581 VERSION NP_009581.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178373.1 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 394) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07147. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..394 /product="Obg-like ATPase" /calculated_mol_wt="44043" Region 1..393 /region_name="PTZ00258" /note="GTP-binding protein; Provisional" /db_xref="CDD:240334" CDS 1..394 /gene="OLA1" /locus_tag="YBR025C" /coded_by="NM_001178373.1:1..1185" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26359986]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:17430889]" /experiment="EXISTENCE:mutant phenotype:GO:1900036 positive regulation of cellular response to heat [PMID:34571008]" /note="P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; positively regulates heat shock response; null mutant displays increased translation rate and increased readthrough of premature stop codons; protein abundance increases in response to hydrogen peroxide and to DNA replication stress" /db_xref="GeneID:852313" /db_xref="SGD:S000000229" ORIGIN 1 mppkkqveek kvllgrpgnn lkagivglan vgkstffqai trcplgnpan ypfatidpee 61 arvivpsprf dklceiykkt asevpahltv ydiagltkga sageglgnaf lshirsvdsi 121 yqvvrcfdda eiihvegdvd pvrdleiinq elrlkdiefa qkalegaeki akrggqslev 181 kqkkeemdli tkiikllesg qrvanhswts keveiinsmf lltakpciyl inlserdyir 241 kknkhllrik ewvdkyspgd liipfsvsle erlshmsped aeeelkklqt isalpkiitt 301 mrqkldlisf ftcgpdevre wtirrgtkap qaagvihndl mntfilaqvm kcedvfeykd 361 dsaikaagkl mqkgkdyvve dgdiiyfrag agkn // LOCUS NP_009582 380 aa linear PLN 30-JUN-2025 DEFINITION enoyl-[acyl-carrier-protein] reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009582 VERSION NP_009582.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178374.1 REFERENCE 1 (residues 1 to 380) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 380) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 380) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 380) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07148. Method: conceptual translation. FEATURES Location/Qualifiers source 1..380 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..380 /product="enoyl-[acyl-carrier-protein] reductase" /EC_number="1.3.1.104" /calculated_mol_wt="41936" Region 21..345 /region_name="ETR" /note="2-enoyl thioester reductase (ETR); cd08290" /db_xref="CDD:176250" Site order(63,156..157,160,183,185..188,208,261..262,283..286, 308..310) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:176250" Site order(73..74,282..285,291..293,295,298..300,303..307,309) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:176250" CDS 1..380 /gene="ETR1" /locus_tag="YBR026C" /gene_synonym="MRF1; MRF1'" /coded_by="NM_001178374.1:1..1143" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11509667|PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity [PMID:11509667]" /experiment="EXISTENCE:mutant phenotype:GO:0006633 fatty acid biosynthetic process [PMID:11509667]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:11509667]" /note="2-enoyl thioester reductase; member of the medium chain dehydrogenase/reductase family; localized to mitochondria, where it has a probable role in fatty acid synthesis; human MECR functionally complements the respiratory growth defect of the null mutant" /db_xref="GeneID:852314" /db_xref="SGD:S000000230" ORIGIN 1 mlptfkryms ssahqipkhf ksliysthev edctkvlsvk nytpkqdlsq sivlktlafp 61 inpsdinqlq gvypsrpekt ydystdepaa iagnegvfev vslpsgsskg dlklgdrvip 121 lqanqgtwsn yrvfssssdl ikvndldlfs aatvsvngct gfqlvsdyid wnsngnewii 181 qnagtssvsk ivtqvakakg iktlsvirdr dnfdevakvl edkygatkvi sesqnndktf 241 akevlskilg enarvrlaln svggkssasi arklennalm ltyggmskqp vtlptslhif 301 kgltskgywv teknkknpqs kidtisdfik mynyghiisp rdeietltwn tntttdeqll 361 elvkkgitgk gkkkmvvlew // LOCUS NP_001333724 110 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR027C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001333724 VERSION NP_001333724.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001346795.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 110) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA79923. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..110 /product="uncharacterized protein" /calculated_mol_wt="12710" CDS 1..110 /locus_tag="YBR027C" /coded_by="NM_001346795.1:1..333" /note="hypothetical protein; conserved among S. cerevisiae strains; YBR027C is not an essential gene" /db_xref="GeneID:852315" /db_xref="SGD:S000000231" ORIGIN 1 mfkgsvslyi lcfalglrnt fliynvcnni knncmdntsg pigdtifliy giiiiigprr 61 cfffylkrvv llqgthewct qglfpwlkkl eitnvhchlr rfiicqlhli // LOCUS NP_009584 525 aa linear PLN 30-JUN-2025 DEFINITION putative protein kinase YPK3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009584 VERSION NP_009584.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178376.1 REFERENCE 1 (residues 1 to 525) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 525) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 525) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 525) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07149. Method: conceptual translation. FEATURES Location/Qualifiers source 1..525 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..525 /product="putative protein kinase YPK3" /EC_number="2.7.11.1" /calculated_mol_wt="59460" Region 134..406 /region_name="STKc_AGC" /note="Catalytic domain of AGC family Serine/Threonine Kinases; cd05123" /db_xref="CDD:270693" Site order(134..138,142,155,157,215,231..232,234,238,240,277, 279,281..282,284,294..295,298,322..327,354,360,363) /site_type="active" /db_xref="CDD:270693" Site order(134..138,142,155,157,215,232..234,238,277,279, 281..282,284,294..295) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270693" Site order(138,238,240,277,279,281,298,322..327,354,360,363) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270693" Site order(294..301,321..327) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270693" Region 445..516 /region_name="S_TK_X" /note="Extension to Ser/Thr-type protein kinases; smart00133" /db_xref="CDD:214529" CDS 1..525 /gene="YPK3" /locus_tag="YBR028C" /coded_by="NM_001178376.1:1..1578" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:26582391]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22289182|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0018105 peptidyl-serine phosphorylation [PMID:26582391]" /experiment="EXISTENCE:direct assay:GO:0046777 protein autophosphorylation [PMID:26582391]" /experiment="EXISTENCE:genetic interaction:GO:0004674 protein serine/threonine kinase activity [PMID:26582391]" /experiment="EXISTENCE:genetic interaction:GO:0018105 peptidyl-serine phosphorylation [PMID:26582391]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:26582391]" /experiment="EXISTENCE:mutant phenotype:GO:0018105 peptidyl-serine phosphorylation [PMID:25767889|PMID:26582391]" /experiment="EXISTENCE:mutant phenotype:GO:0046777 protein autophosphorylation [PMID:26582391]" /note="AGC kinase; phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner; directly phosphorylated by TORC1; phosphorylates ribosomal protein Rps6a/b (S6), in a TORC-dependent manner; undergoes autophosphorylation" /db_xref="GeneID:852316" /db_xref="SGD:S000000232" ORIGIN 1 mifsldeelh rvslddkknd ikvdyssaiy ndinheqgss ityeesinhl svhsnaipln 61 gmspahrmrr rssayskfpi ltppntrrfs itgsdamrtn tnrlsitpqd iissnigene 121 lsrnlhdfkp vrvlgqgayg kvllvkdvnt sklyamkqlr kaeilisqta tdskrededk 181 ndgnnndndd glskrlertf aersilseie hpnivklfys fhdnsklyll lqyipggelf 241 yhlkehgtld ettvsfyaae iscalrflht kgvvyrdlkp encllnqrgh lvltdfglsk 301 ksandsavde edpenvnaly siigtpeyca peillgkays qncdwyslgc llydmlvgkp 361 pytgsnhkvi inkiqqnkqg pkipfylseg mkdilnallk ketakrwnvd kywaktgann 421 kptkskkkks gaartslfte hfifrkidwk llesgqlqkt tlgpivpvit dlelaenfdt 481 eftsmsyeet ytdskpinin svskspdmfk gfsykasgsy lekyf // LOCUS NP_009585 457 aa linear PLN 30-JUN-2025 DEFINITION phosphatidate cytidylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009585 VERSION NP_009585.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178377.1 REFERENCE 1 (residues 1 to 457) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 457) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 457) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 457) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07150. Method: conceptual translation. FEATURES Location/Qualifiers source 1..457 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..457 /product="phosphatidate cytidylyltransferase" /EC_number="2.7.7.41" /calculated_mol_wt="51692" Region 96..420 /region_name="CTP_transf_1" /note="Cytidylyltransferase family; cl21502" /db_xref="CDD:451277" CDS 1..457 /gene="CDS1" /locus_tag="YBR029C" /gene_synonym="CDG1" /coded_by="NM_001178377.1:1..1374" /experiment="EXISTENCE:direct assay:GO:0004605 phosphatidate cytidylyltransferase activity [PMID:8557688]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:23623749|PMID:8557688]" /experiment="EXISTENCE:direct assay:GO:0070319 Golgi to plasma membrane transport vesicle [PMID:2163397]" /experiment="EXISTENCE:mutant phenotype:GO:0006658 phosphatidylserine metabolic process [PMID:2832385]" /experiment="EXISTENCE:mutant phenotype:GO:0016024 CDP-diacylglycerol biosynthetic process [PMID:2832385]" /experiment="EXISTENCE:mutant phenotype:GO:0046488 phosphatidylinositol metabolic process [PMID:8557688|PMID:2832385]" /note="Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids; human homolog CDS1 can complement yeast cds1 null mutant" /db_xref="GeneID:852317" /db_xref="SGD:S000000233" ORIGIN 1 msdnpemkph gtskeivesv tdatskaidk lqeelhkdas esvtpvtkes taatkesrky 61 nffirtvwtf vmisgffitl asghawcivl ilgcqiatfk eciavtsasg reknlpltkt 121 lnwyllftti yyldgkslfk ffqatfyeyp vlnfivtnhk ficyclylmg fvlfvcslrk 181 gflkfqfgsl cvthmvlllv vfqahliikn vlnglfwfll pcglvivndi faylcgitfg 241 ktklieispk ktlegflgaw fftalasiil trilspytyl tcpvedlhtn ffsnltceln 301 pvflpqvyrl ppiffdkvqi nsitvkpiyf halnlatfas lfapfggffa sglkrtfkvk 361 dfghsipghg gitdrvdcqf imgsfanlyy etfisehrit vdtvlstilm nlndkqiiel 421 idilirflsk kgiisaknfe kladifnvtk ksltnhs // LOCUS NP_009586 552 aa linear PLN 30-JUN-2025 DEFINITION protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009586 VERSION NP_009586.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178378.1 REFERENCE 1 (residues 1 to 552) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 552) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 552) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 552) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07151. Method: conceptual translation. FEATURES Location/Qualifiers source 1..552 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..552 /product="protein-lysine N-methyltransferase" /calculated_mol_wt="62463" Region 27..349 /region_name="SET_LSMT" /note="SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; cd10527" /db_xref="CDD:380925" Site order(37..38,203..204,221..226,334,346,348) /site_type="other" /note="SAM binding site" /db_xref="CDD:380925" Site order(37..38,201..206,221..225,300,332..335) /site_type="active" /note="putative active site [active]" /db_xref="CDD:380925" CDS 1..552 /gene="RKM3" /locus_tag="YBR030W" /coded_by="NM_001178378.1:1..1659" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:genetic interaction:GO:0016279 protein-lysine N-methyltransferase activity [PMID:18957409]" /experiment="EXISTENCE:genetic interaction:GO:0018026 peptidyl-lysine monomethylation [PMID:18957409]" /experiment="EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:18957409]" /experiment="EXISTENCE:mutant phenotype:GO:0018026 peptidyl-lysine monomethylation [PMID:18957409|PMID:24517342]" /note="Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852318" /db_xref="SGD:S000000234" ORIGIN 1 msvtfkddvh rilkfvancn grfedskcdi resplgglgv faktdiaege siltlnkssi 61 fsasnssian llcdssidgm lalniafiye ttvfrnsshw ypflrtirir ddeghlnlpp 121 sfwhadakrl lkgtsfdtlf dslapeeeim egfeiavdla hkwndefgle ipkgfldvse 181 enheedynlk lekfisvayt lssrgfeida yhetalvpia dlfnhhvsdp dlkfvslydv 241 cdkcgepdmc khliaeeyle aenldknmpk vasmetrvid edlikslend lekeysnvta 301 niedddggie npdecvdlvl kndvaqgqei fnsygelsnv fllarygftv penqydivhl 361 gpdfmkilkk eekyqekvkw wsqvghglfs awyaqmrqed eededgqaks dnlsddiese 421 eeeeeeegdd sleswlsqly idssgepsps twalanlltl tavqweslfs kkatphisds 481 ivneeklpfl akkdnphskk llsnllkekq lpcikgdnss kitsatksml qnartlvqse 541 hnildrclkr ls // LOCUS NP_009587 362 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL4 RPL4A [Saccharomyces cerevisiae S288C]. ACCESSION NP_009587 VERSION NP_009587.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178379.1 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 362) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07152. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..362 /product="60S ribosomal protein uL4 RPL4A" /calculated_mol_wt="38961" Region 2..350 /region_name="PTZ00428" /note="60S ribosomal protein L4; Provisional" /db_xref="CDD:185611" CDS 1..362 /gene="RPL4A" /locus_tag="YBR031W" /coded_by="NM_001178379.1:1..1089" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L4A; N-terminally acetylated; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4A has a paralog, RPL4B, that arose from the whole genome duplication" /db_xref="GeneID:852319" /db_xref="SGD:S000000235" ORIGIN 1 msrpqvtvhs ltgeatanal plpavfsapi rpdivhtvft svnknkrqay avsekaghqt 61 saeswgtgra variprvggg gtgrsgqgaf gnmcrggrmf aptktwrkwn vkvnhnekry 121 atasaiaata vaslvlargh rvekipeipl vvstdlesiq ktkeavaalk avgahsdllk 181 vlkskklrag kgkyrnrrwt qrrgplvvya edngivkalr nvpgvetanv aslnllqlap 241 gahlgrfviw teaaftkldq vwgsetvass kvgytlpshi istsdvtrii nsseiqsair 301 pagqatqkrt hvlkknplkn kqvllrlnpy akvfaaeklg skkaektgtk paavftetlk 361 hd // LOCUS NP_001333725 100 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR032W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001333725 VERSION NP_001333725.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001346796.1 REFERENCE 1 (residues 1 to 100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 100) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA79924. Method: conceptual translation. FEATURES Location/Qualifiers source 1..100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..100 /product="uncharacterized protein" /calculated_mol_wt="11354" CDS 1..100 /locus_tag="YBR032W" /coded_by="NM_001346796.1:1..303" /note="hypothetical protein; conserved among S. cerevisiae strains; YBR032W is not an essential gene" /db_xref="GeneID:852320" /db_xref="SGD:S000000236" ORIGIN 1 mviiritlsn llrekgdlcl ellrvdkgiy pfdtsqpigs mqvllphasn ypgsaqfylf 61 daatklgfeq svnlnysenh wlnntpcqyl yvflqqarle // LOCUS NP_009589 919 aa linear PLN 30-JUN-2025 DEFINITION Eds1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009589 VERSION NP_009589.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178381.1 REFERENCE 1 (residues 1 to 919) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 919) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 919) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 919) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 919) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 919) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 919) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07153. Method: conceptual translation. FEATURES Location/Qualifiers source 1..919 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..919 /product="Eds1p" /calculated_mol_wt="103266" Site order(51,55,60..63,65,70,80) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Region 54..95 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(56,59,66,75,78,85) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..919 /gene="EDS1" /locus_tag="YBR033W" /coded_by="NM_001178381.1:1..2760" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication" /db_xref="GeneID:852321" /db_xref="SGD:S000000237" ORIGIN 1 mshhvpnlyg tpirdpherk rnsasmgevn qsvssrncer gsekgtkqrk kashacdqcr 61 rkrikcrfdk htgvcqgcle vgekcqfirv plkrgpakkr gsvvsiekfs sdndplqyrp 121 rthsypmnsg nnylpslarn ssfpsisslf vpsitaqsqq fvkvpyddik rrsslailgs 181 dssistefgg nyrldenlnv rqegkdivak gmitpveemg acssnvrrqg sqslpiqeqr 241 aspyinpfis grsrlsslsy tseattsegn tqgknqcmlt pnsvrsieke rlnsltagfp 301 nkklgtdgrs dkwdknstwk pvyrssnpsh psteknvsln qeasakplml gtyrqfdats 361 fykvlgiyyn ffhinfpvip inkskftdml dpekpnvide irqinneiiq cfktalevlv 421 fckikqrrss kstkswsrds lcdfqkglyy iqnfnkciad cfqslitikp vlkqnssvip 481 srikfiyfst iivlnfilil ageesslllg psvgvfnefq ahklflpfqn tspmlllnsn 541 eesgdeildy avlfkrlyil lnildtlqsf rlgqpklinl nfgsaietyf sdktghnqvv 601 ekapvaldni lrnlklgefi tyfvlnrksl qvnvphhllf tnqtdygefa vekgehdnia 661 gkfetllkkk eilirkllni eqkndhilen ccnsdaemkn igelvcsmit lvsgildsit 721 nmnaensvdl dskplpnayf aqdseeelms ptqsitsnla seentrcttk dlmgtvsifm 781 lpmveecyni isligpiptt lislyirngn makgindrim tlstalnelv qitalfntle 841 pfrknahdra kryyvsatss tgcyesvmks mysgkcaasn asnvapseee nkkilkkfad 901 igwklmddse lgccccffn // LOCUS NP_009590 348 aa linear PLN 30-JUN-2025 DEFINITION protein-arginine omega-N methyltransferase HMT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009590 VERSION NP_009590.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178382.1 REFERENCE 1 (residues 1 to 348) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 348) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 348) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 348) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07154. Method: conceptual translation. FEATURES Location/Qualifiers source 1..348 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..348 /product="protein-arginine omega-N methyltransferase HMT1" /EC_number="2.1.1.319" /calculated_mol_wt="39655" Region 33..>207 /region_name="COG4076" /note="Predicted RNA methylase [General function prediction only]" /db_xref="CDD:443253" CDS 1..348 /gene="HMT1" /locus_tag="YBR034C" /gene_synonym="HCP1; ODP1; RMT1" /coded_by="NM_001178382.1:1..1047" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8668183]" /experiment="EXISTENCE:direct assay:GO:0018216 peptidyl-arginine methylation [PMID:8647869|PMID:25715670|PMID:22997150]" /experiment="EXISTENCE:direct assay:GO:0035241 protein-arginine omega-N monomethyltransferase activity [PMID:8647869]" /experiment="EXISTENCE:direct assay:GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity [PMID:8647869]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:8668183]" /experiment="EXISTENCE:mutant phenotype:GO:0018216 peptidyl-arginine methylation [PMID:20035717|PMID:8647869|PMID:18515076]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:20053728]" /experiment="EXISTENCE:mutant phenotype:GO:0035241 protein-arginine omega-N monomethyltransferase activity [PMID:8647869]" /experiment="EXISTENCE:mutant phenotype:GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity [PMID:8647869]" /experiment="EXISTENCE:mutant phenotype:GO:0046656 folic acid biosynthetic process [PMID:31515157]" /experiment="EXISTENCE:mutant phenotype:GO:0060567 negative regulation of termination of DNA-templated transcription [PMID:20053728]" /note="Nuclear SAM-dependent mono- and asymmetric methyltransferase; modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p, ribosomal protein Rps2p, and histones H3 and H4; interacts genetically with genes encoding components of Rpd3(L) and this interaction is important for Rpd3 recruitment to the subtelomeric region" /db_xref="GeneID:852322" /db_xref="SGD:S000000238" ORIGIN 1 msktavkdsa tektklsese qhyfnsydhy giheemlqdt vrtlsyrnai iqnkdlfkdk 61 ivldvgcgtg ilsmfaakhg akhvigvdms siiemakelv elngfsdkit llrgkledvh 121 lpfpkvdiii sewmgyflly esmmdtvlya rdhylveggl ifpdkcsihl agledsqykd 181 eklnywqdvy gfdyspfvpl vlhepivdtv ernnvnttsd kliefdlntv kisdlafksn 241 fkltakrqdm ingivtwfdi vfpapkgkrp vefstgphap ythwkqtify fpddldaetg 301 dtiegelvcs pneknnrdln ikisykfesn gidgnsrsrk negsylmh // LOCUS NP_009591 228 aa linear PLN 30-JUN-2025 DEFINITION pyridoxamine-phosphate oxidase PDX3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009591 VERSION NP_009591.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178383.1 REFERENCE 1 (residues 1 to 228) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 228) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 228) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 228) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07155. Method: conceptual translation. FEATURES Location/Qualifiers source 1..228 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..228 /product="pyridoxamine-phosphate oxidase PDX3" /EC_number="1.4.3.5" /calculated_mol_wt="26777" Region 34..228 /region_name="pdxH" /note="pyridoxamine-phosphate oxidase; TIGR00558" /db_xref="CDD:273138" CDS 1..228 /gene="PDX3" /locus_tag="YBR035C" /coded_by="NM_001178383.1:1..687" /experiment="EXISTENCE:curator inference:GO:0009443 pyridoxal 5'-phosphate salvage [PMID:7896706]" /experiment="EXISTENCE:direct assay:GO:0004733 pyridoxamine phosphate oxidase activity [PMID:26327315]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0010181 FMN binding [PMID:26327315]" /experiment="EXISTENCE:mutant phenotype:GO:0004733 pyridoxamine phosphate oxidase activity [PMID:7896706]" /note="Pyridoxine (pyridoxamine) phosphate oxidase; has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism" /db_xref="GeneID:852323" /db_xref="SGD:S000000239" ORIGIN 1 mtkqaeetqk piifapetyq ydkftlnekq ltddpidlft kwfneakedp retlpeaitf 61 ssaelpsgrv ssrillfkel dhrgftiysn wgtsrkahdi atnpnaaivf fwkdlqrqvr 121 vegitehvnr etseryfktr prgskigawa srqsdviknr eeldeltqkn terfkdaedi 181 pcpdywgglr ivpleiefwq grpsrlhdrf vyrrktendp wkvvrlap // LOCUS NP_009592 410 aa linear PLN 30-JUN-2025 DEFINITION mannosylinositol phosphorylceramide synthase regulatory subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_009592 VERSION NP_009592.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178384.1 REFERENCE 1 (residues 1 to 410) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 410) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 410) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 410) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07156. Method: conceptual translation. FEATURES Location/Qualifiers source 1..410 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..410 /product="mannosylinositol phosphorylceramide synthase regulatory subunit" /calculated_mol_wt="45311" Region 1..403 /region_name="CSG2" /note="Ceramide synthase regulator; pfam16965" /db_xref="CDD:374907" CDS 1..410 /gene="CSG2" /locus_tag="YBR036C" /gene_synonym="CLS2" /coded_by="NM_001178384.1:1..1233" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:37349354|PMID:7854312]" /experiment="EXISTENCE:direct assay:GO:0015278 intracellularly gated calcium channel activity [PMID:37349354]" /experiment="EXISTENCE:mutant phenotype:GO:0006688 glycosphingolipid biosynthetic process [PMID:8063782]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:7854312]" /experiment="EXISTENCE:mutant phenotype:GO:0030234 enzyme regulator activity [PMID:12954640]" /experiment="EXISTENCE:mutant phenotype:GO:0032469 endoplasmic reticulum calcium ion homeostasis [PMID:37349354]" /experiment="EXISTENCE:mutant phenotype:GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum [PMID:37349354]" /note="Calcium release channel involved in ER calcium homeostasis; integrates ER calcium release with the regulation of sphingolipid metabolism and autophagy; required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; endoplasmic reticulum membrane protein; contains 10 transmembrane domains and a potential Ca2+ EF-hand motif; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852324" /db_xref="SGD:S000000240" ORIGIN 1 msttllwfss vigyviqtkc lsniqskkei svgpngtiat petngdngns ssltfyltfm 61 yfaswlllvp asrlwekmrp mfvsdsdsnr nsqfdnnnsg svtnedvdtf shvlddpqpr 121 ipaqqqkqki isvatfkyva kltvlalimi vadltynmal slspafdval mqntaifeiv 181 tllygvcgis rknyvfrnfl immnavigil iisytkatcd mlagklsvnp ntgelsdpfl 241 fdrlkgalic glgalimgpf avlwnrwfcs nisknensav vlvkqsthma ligiigmvil 301 lpfipkfpsr esvesislfy ndksfwfsll gsiifgslps lisilelnrk apaeylttcn 361 lgaiifmgla ewvceptqtt ivrwevigyi mltvsllvls vtlgegkyhh // LOCUS NP_009593 295 aa linear PLN 30-JUN-2025 DEFINITION Cu-binding protein SCO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009593 VERSION NP_009593.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178385.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 295) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07157. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..295 /product="Cu-binding protein SCO1" /calculated_mol_wt="33035" Region 115..257 /region_name="SCO" /note="SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; cd02968" /db_xref="CDD:239266" Site order(148,152,239) /site_type="other" /note="Cu(I) binding site [ion binding]" /db_xref="CDD:239266" CDS 1..295 /gene="SCO1" /locus_tag="YBR037C" /gene_synonym="PET161" /coded_by="NM_001178385.1:1..888" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:11546815]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:1944230]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:30593977]" /experiment="EXISTENCE:genetic interaction:GO:0045454 cell redox homeostasis [PMID:30593977]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:10854440]" /note="Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication" /db_xref="GeneID:852325" /db_xref="SGD:S000000241" ORIGIN 1 mlklsrsanl rlvqlpaarl sgngaklltq rgfftvtrlw qsngkkplsr vpvggtpikd 61 ngkvregsie fstgkaialf lavggalsyf fnrekrrlet qkeaeanrgy gkpslggpfh 121 ledmygneft eknllgkfsi iyfgfsncpd icpdeldklg lwlntlssky gitlqplfit 181 cdpardspav lkeylsdfhp silgltgtfd evknackkyr vyfstppnvk pgqdylvdhs 241 iffylmdpeg qfvdalgrny dektgvdkiv ehvksyvpae qrakqkeawy sflfk // LOCUS NP_009594 963 aa linear PLN 30-JUN-2025 DEFINITION chitin synthase CHS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009594 VERSION NP_009594.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178386.1 REFERENCE 1 (residues 1 to 963) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 963) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 963) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 963) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 963) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 963) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 963) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07158. Method: conceptual translation. FEATURES Location/Qualifiers source 1..963 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..963 /product="chitin synthase CHS2" /EC_number="2.4.1.16" /calculated_mol_wt="109751" Region 237..297 /region_name="Chitin_synth_1N" /note="Chitin synthase N-terminal; pfam08407" /db_xref="CDD:462467" Region 294..612 /region_name="Chitin_synth_C" /note="C-terminal domain of Chitin Synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin; cd04190" /db_xref="CDD:133033" Site order(297,299,443) /site_type="active" /note="Ligand binding site [active]" /db_xref="CDD:133033" Site 441..443 /site_type="active" /note="DXD motif [active]" /db_xref="CDD:133033" Region <559..704 /region_name="BcsA" /note="Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]; COG1215" /db_xref="CDD:440828" CDS 1..963 /gene="CHS2" /locus_tag="YBR038W" /coded_by="NM_001178386.1:1..2892" /experiment="EXISTENCE:direct assay:GO:0004100 chitin synthase activity [PMID:9990311]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:8909536|PMID:15772160]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:22573892]" /experiment="EXISTENCE:mutant phenotype:GO:1902404 mitotic actomyosin contractile ring contraction [PMID:15772160]" /note="Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis; phosphorylation by Dbf2p kinase regulates its dynamics and chitin synthesis during cytokinesis" /db_xref="GeneID:852326" /db_xref="SGD:S000000242" ORIGIN 1 mtrnpfmvep sngspnrrga snlskfyana nsnsrwanps eesledsydq snvfqglpas 61 psraalrysp drrhrtqfyr dsahnspvap nryaanlqes pkrageavih lsegsnlypr 121 dnadlpvdpy hlspqqqpsn nlfgsgrlys qsskytmstt sttapslaea ddekekylts 181 ttsyddqsti fsadtfnetk felnhptrqq yvrransesk rrmvsdlppp skkkallkld 241 npipkglldt lprrnspeft emrytactve pddflregyt lrfaemnrec qiaicitmyn 301 edkyslarti hsimknvahl ckrekshvwg pngwkkvsvi lisdgrakvn qgsldylaal 361 gvyqedmaka svngdpvkah ifelttqvsi nadldyvskd ivpvqlvfcl keenkkkins 421 hrwlfnafcp vlqptvvtlv dvgtrlnnta iyrlwkvfdm dsnvagaagq iktmkgkwgl 481 klfnplvasq nfeykisnil dkplesvfgy isvlpgalsa yryralknhe dgtgplrsyf 541 lgetqegrdh dvftanmyla edrilcwelv akrdakwvlk yvkeatgetd vpedvsefis 601 qrrrwlngam faaiyaqlhf yqiwktkhsv vrkfflhvef lyqfiqmlfs wfsianfvlt 661 fyylagsmnl vikhgealfi ffkylifcdl aslfiismgn rpqgakhlfi tsmvilsica 721 tyslicgfvf afkslasgte shkifvdivi sllstyglyf fsslmyldpw hmftssiqyf 781 ltlpaftctl qifafcnthd vswgtkgstq eskqlskaiv vqgpdgkqiv etdwpqevdk 841 kfleiksrlk epefeessgn ekqskndyyr dirtrivmiw mlsnlilims iiqvftpqdt 901 dngylifilw svaalaafrv vgsmaflfmk ylriivsyrn kvegsgswev skldlpnvfh 961 kkg // LOCUS NP_009595 311 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit gamma [Saccharomyces cerevisiae S288C]. ACCESSION NP_009595 VERSION NP_009595.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178387.1 REFERENCE 1 (residues 1 to 311) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 311) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 311) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 311) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07159. Method: conceptual translation. FEATURES Location/Qualifiers source 1..311 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..311 /product="F1F0 ATP synthase subunit gamma" /calculated_mol_wt="34220" Region 34..310 /region_name="ATPsyn_F1gamma" /note="ATP synthase, F1 gamma subunit; TIGR01146" /db_xref="CDD:273469" Site order(37,42,48,52,55..56,58..59,62..63,114,116..119, 145..146,149..150,153,273,276..277,280,286,289..290, 292..293,296..297,300,302..307) /site_type="other" /note="core domain interface [polypeptide binding]" /db_xref="CDD:213394" Site order(73..74,76..77,80,83..84,238,241..242,245) /site_type="other" /note="delta subunit interface [polypeptide binding]" /db_xref="CDD:213394" Site order(148,160..165,241,244..245) /site_type="other" /note="epsilon subunit interface [polypeptide binding]" /db_xref="CDD:213394" CDS 1..311 /gene="ATP3" /locus_tag="YBR039W" /coded_by="NM_001178387.1:1..936" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0045259 proton-transporting ATP synthase complex [PMID:17082766]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:7929329]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:7929329]" /experiment="EXISTENCE:mutant phenotype:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:7929329]" /note="Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis" /db_xref="GeneID:852327" /db_xref="SGD:S000000243" ORIGIN 1 mlsrivsnna trsvmchqaq vgilyktnpv rtyatlkeve mrlksiknie kitktmkiva 61 strlskaeka kisakkmdea eqlfyknaet knldveatet gapkelivai tsdkglcgsi 121 hsqlakavrr hlndqpnadi vtigdkikmq llrthpnnik lsingigkda ptfqesalia 181 dkllsvmkag typkisifyn dpvsslsfep sekpifnakt ieqspsfgkf eidtdanvpr 241 dlfeytlanq mltamaqgya aeisarrnam dnasknagdm inrysilynr trqavitnel 301 vdiitgassl g // LOCUS NP_009596 298 aa linear PLN 30-JUN-2025 DEFINITION Fig1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009596 VERSION NP_009596.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178388.1 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 298) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07160. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..298 /product="Fig1p" /calculated_mol_wt="33645" Region 67..262 /region_name="Fig1" /note="Ca2+ regulator and membrane fusion protein Fig1; pfam12351" /db_xref="CDD:372065" CDS 1..298 /gene="FIG1" /locus_tag="YBR040W" /coded_by="NM_001178388.1:1..897" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9456310]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12374868]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:9456310]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:9456310]" /note="Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:852328" /db_xref="SGD:S000000244" ORIGIN 1 mvaismiwff tkrmprifal afnlisifll iflligcynp snqstflvky kfddnspfyt 61 iieksyeksn ttlgleevii rsgymgvcid nipsqyssyn nmttfsnsic yarknlssvp 121 lyrdleiqls niassssktq ssvvlnilkl aqltsvnvih pyvlmatvil tilmflfily 181 vtvpklpfkl avnkflllls stivltwgig amwthvgina syrlvpsssm niitvkkgkk 241 aavmawfsfa fllldsvvlw liflrdrksl kdeidnvpca qnrynnyssd sstlhskv // LOCUS NP_009597 669 aa linear PLN 30-JUN-2025 DEFINITION long-chain fatty acid transporter FAT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009597 VERSION NP_009597.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178389.1 REFERENCE 1 (residues 1 to 669) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 669) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 669) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 669) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07161. On Feb 2, 2004 this sequence version replaced NP_009597.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..669 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..669 /product="long-chain fatty acid transporter FAT1" /calculated_mol_wt="77010" Region 107..634 /region_name="FATP_chFAT1_like" /note="Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; cd05937" /db_xref="CDD:341260" Site order(254,257..262,264..265) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341260" Site order(257,372..373,393..398,508,520,523,534,621) /site_type="other" /note="putative AMP binding site [chemical binding]" /db_xref="CDD:341260" Site order(257,297..298,354,356..357,360,372..373,393..398,508, 520,523,531..534,602) /site_type="active" /note="putative active site [active]" /db_xref="CDD:341260" Site order(297,356..357,360,372,531..533,593,602) /site_type="other" /note="putative CoA binding site [chemical binding]" /db_xref="CDD:341260" CDS 1..669 /gene="FAT1" /locus_tag="YBR041W" /coded_by="NM_001178389.1:1..2010" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:9988704]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093|PMID:10515935]" /experiment="EXISTENCE:direct assay:GO:0009898 cytoplasmic side of plasma membrane [PMID:17679730]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0044539 long-chain fatty acid import into cell [PMID:12601005]" /experiment="EXISTENCE:mutant phenotype:GO:0000038 very long-chain fatty acid metabolic process [PMID:9660783|PMID:9988704]" /experiment="EXISTENCE:mutant phenotype:GO:0005324 long-chain fatty acid transmembrane transporter activity [PMID:9079682]" /experiment="EXISTENCE:mutant phenotype:GO:0005777 peroxisome [PMID:9660783]" /experiment="EXISTENCE:mutant phenotype:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:31746669]" /experiment="EXISTENCE:mutant phenotype:GO:0031957 very long-chain fatty acid-CoA ligase activity [PMID:9660783]" /experiment="EXISTENCE:mutant phenotype:GO:0044539 long-chain fatty acid import into cell [PMID:10880966|PMID:12601005]" /note="Very long chain fatty acyl-CoA synthetase and fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids" /db_xref="GeneID:852329" /db_xref="SGD:S000000245" ORIGIN 1 mspiqvvvfa lsriflllfr likliitpiq kslgylfgny fdeldrkyry kedwyiipyf 61 lksvfcyiid vrrhrfqnwy lfikqvqqng dhlaisytrp maekgefqle tftyietyni 121 vlrlshilhf dynvqagdyv aidctnkplf vflwlslwni gaipaflnyn tkgtplvhsl 181 kisnitqvfi dpdasnpire seeeiknalp dvklnyleeq dlmhellnsq speflqqdnv 241 rtplgltdfk psmliytsgt tglpksaims wrkssvgcqv fghvlhmtne stvftamplf 301 hstaallgac ailshggcla lshkfsastf wkqvyltgat hiqyvgevcr yllhtpisky 361 ekmhkvkvay gnglrpdiwq dfrkrfniev igefyaatea pfatttfqkg dfgigacrny 421 gtiiqwflsf qqtlvrmdpn ddsviyrnsk gfcevapvge pgemlmriff pkkpetsfqg 481 ylgnaketks kvvrdvfrrg dawyrcgdll kadeyglwyf ldrmgdtfrw ksenvsttev 541 edqltasnke qyaqvlvvgi kvpkyegrag favikltdns lditaktkll ndslsrlnlp 601 syamplfvkf vdeikmtdnh kilkkvyreq klpkgldgnd tifwlknykr yevltaadwe 661 aidaqtikl // LOCUS NP_009598 397 aa linear PLN 30-JUN-2025 DEFINITION putative acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009598 VERSION NP_009598.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178390.1 REFERENCE 1 (residues 1 to 397) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 397) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 397) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 397) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07162. Method: conceptual translation. FEATURES Location/Qualifiers source 1..397 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..397 /product="putative acyltransferase" /calculated_mol_wt="45384" Region 103..314 /region_name="LPLAT_LCLAT1-like" /note="Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; cd07990" /db_xref="CDD:153252" Site order(112,115,117,138..141,226..228) /site_type="active" /note="putative acyl-acceptor binding pocket [active]" /db_xref="CDD:153252" Region 300..361 /region_name="Acyltransf_C" /note="Acyltransferase C-terminus; pfam16076" /db_xref="CDD:465006" CDS 1..397 /gene="CST26" /locus_tag="YBR042C" /gene_synonym="PSI1" /coded_by="NM_001178390.1:1..1194" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0016746 acyltransferase activity [PMID:27462707|PMID:19796168]" /experiment="EXISTENCE:mutant phenotype:GO:0036149 phosphatidylinositol acyl-chain remodeling [PMID:19796168|PMID:27462707]" /note="Acyltransferase; enzyme mainly responsible for the introduction of saturated very long chain fatty acids into neo-synthesized molecules of phosphatidylinositol; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication" /db_xref="GeneID:852330" /db_xref="SGD:S000000246" ORIGIN 1 mlhqkiahkv rkvvvpgisl liffqgclil lflqltyktl ycrndirkqi glnktkrlfi 61 vlvssilhvv apsavritte nssvpkgtff ldlkkkrils hlksnsvaic nhqiytdwif 121 lwwlaytsnl ganvfiilkk slasipilgf gmrnynfifm srkwaqdkit lsnslaglds 181 nargagslag ksperiteeg esiwnpevid pkqihwpynl ilfpegtnls adtrqksaky 241 aakigkkpfk nvllphstgl ryslqklkps ieslyditig ysgvkqeeyg eliyglksif 301 legkypklvd ihirafdvkd ipledenefs ewlykiwsek dalmeryyst gsfvsdpetn 361 hsvtdsfkin rieltevlil ptltiiwlvy klycfif // LOCUS NP_009599 689 aa linear PLN 30-JUN-2025 DEFINITION Qdr3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009599 VERSION NP_009599.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178391.2 REFERENCE 1 (residues 1 to 689) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 689) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 689) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 689) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07163. On Apr 26, 2011 this sequence version replaced NP_009599.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..689 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..689 /product="Qdr3p" /calculated_mol_wt="77156" Region 110..676 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(120..121,124..125,128,160,210..211,213..215,218,238, 241..242,245,483,486..487,490..492,495,520,524,596..597, 601,605,620,623..624,627..628,631) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..689 /gene="QDR3" /locus_tag="YBR043C" /gene_synonym="AQR2" /coded_by="NM_001178391.2:1..2070" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:34887841|PMID:15649438]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]" /experiment="EXISTENCE:mutant phenotype:GO:0010509 intracellular polyamine homeostasis [PMID:21148207]" /experiment="EXISTENCE:mutant phenotype:GO:0015203 polyamine transmembrane transporter activity [PMID:21148207]" /experiment="EXISTENCE:mutant phenotype:GO:0015562 efflux transmembrane transporter activity [PMID:15649438]" /experiment="EXISTENCE:mutant phenotype:GO:0015565 threonine efflux transmembrane transporter activity [PMID:34887841]" /experiment="EXISTENCE:mutant phenotype:GO:0032973 amino acid export across plasma membrane [PMID:34887841]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:15649438]" /note="Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin" /db_xref="GeneID:852331" /db_xref="SGD:S000000247" ORIGIN 1 mqaqgsqsnv gslrsncsdn slpnnhvmmh cdessgsphs ehndysyekt nlestasnsr 61 ehrdnqlsrl kseeyvvpkn qrrgllpqla iipefkdard yppmmkkmiv fliafssmmg 121 pmgtsiifpa insittefkt svimvnvsig vyllslgvfp lwwsslsele grrttyitsf 181 allfafnigs alapdinsfi alrmlcgaas asvqsvgagt vadlyisedr gknlsyyylg 241 pllapllspi fgsllvnrwp wrstqwfmvi lsgcnvillt vllpetlrkq dskgaiaqil 301 aerriqvdnn ergeiqedyq rgedetdrie nqvatlstek hnyvgevrdq dsldleshss 361 pntydgrage tqlqriytea srslyeyqld dsgidattaq vtrirstdpk larsirensl 421 rklqtnleeq vkkvlssngg eiapkqvsav rkvwdtffvy fikplkslhf leyppvalai 481 tfsaisfstv yfvnmtveyk ysrppynfkp lyigllyipn svtyffasiy ggrwvdmllk 541 rykekygila peariswnvv tsvisfpial lifgwcldkk chwvtpligt alfgyaammt 601 igatlsylvd slpgkgatgv alnnlirqil aatavfvttp mlngmgtgwa ftmlafivlg 661 assvliilkk hgdywrenyd lqklydkid // LOCUS NP_009600 572 aa linear PLN 30-JUN-2025 DEFINITION Tcm62p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009600 VERSION NP_009600.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178392.2 REFERENCE 1 (residues 1 to 572) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 572) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 572) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 572) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07164. On Apr 26, 2011 this sequence version replaced NP_009600.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..572 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..572 /product="Tcm62p" /calculated_mol_wt="64121" Region 124..492 /region_name="PTZ00114" /note="Heat shock protein 60; Provisional" /db_xref="CDD:185455" CDS 1..572 /gene="TCM62" /locus_tag="YBR044C" /coded_by="NM_001178392.2:1..1719" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9822678]" /experiment="EXISTENCE:mutant phenotype:GO:0034553 mitochondrial respiratory chain complex II assembly [PMID:9822678]" /note="Protein involved in assembly of the succinate dehydrogenase complex; mitochondrial; putative chaperone" /db_xref="GeneID:852332" /db_xref="SGD:S000000248" ORIGIN 1 mlrnclrklg nhqtkcsvkt lhtpiyrtkn lqvlrdtlsg ikllekiits ssynktliye 61 pkykskpqvv sshdtmrlhn vmrelldslq vdeatntrlq snrprklgrv glqlfmdciq 121 dnltatstsl tcsllehyfk ypekevtngi kaglryirdf laknkiivks qndvdalveq 181 ltmsssdsqs ikrvlkainy elfsddivrv ingnktydev dvskgwkypa gildsneayl 241 rslelptkkl vsidkdmlvl mydgtlrdan kilptityar klrksvlliv ngdctgdalt 301 svtinnnrnk rennesrivv lkyskkannd lapqenldfi kflrlpcgyd siyspeyspl 361 vpskmcadky ygsiesikat tgeaflynsi daeaipnkvp ksflqntvtl sigghneiei 421 drrrnaidnc lnnvlchgla kgfipgygis llkaipglne lkanepnfmt kvginavlsa 481 vilpsevafk naygynyyei nsliagaine ksfpmakfsp nsepvntvkd gnlepwskmd 541 sclagvetfi elltscntii tcvykkperh ka // LOCUS NP_009601 639 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase regulator GIP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009601 VERSION NP_009601.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178393.2 REFERENCE 1 (residues 1 to 639) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 639) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 639) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 639) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07165. On Apr 26, 2011 this sequence version replaced NP_009601.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..639 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..639 /product="protein phosphatase regulator GIP1" /calculated_mol_wt="73224" CDS 1..639 /gene="GIP1" /locus_tag="YBR045C" /coded_by="NM_001178393.2:1..1920" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:11724821]" /experiment="EXISTENCE:direct assay:GO:0019888 protein phosphatase regulator activity [PMID:11724821]" /experiment="EXISTENCE:mutant phenotype:GO:0008157 protein phosphatase 1 binding [PMID:9584086]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:11724821]" /experiment="EXISTENCE:physical interaction:GO:0000164 protein phosphatase type 1 complex [PMID:9584086]" /note="Meiosis-specific regulatory subunit of the Glc7p protein phosphatase; regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p" /db_xref="GeneID:852334" /db_xref="SGD:S000000249" ORIGIN 1 metilqpkar pfeslkrkrf rewlrpstah gsllhsdtld lrdfakpnpa dtfsnldsgh 61 cplvttpiky ecpdgkssff rgdtkfetlf snrkfyefkd nlkrglkkir hgrnghqsek 121 rcpvveetkk svsdnldkpd nntpcfdrfh tnskefetqf dhsnrsqnse kayldnescw 181 nlsekfipfn nlkyedlkhf eenlqslapa tftpiesnes ldrsdstrgt krsirndssd 241 ttsekrlclk qysdepesdh smestpsiyi tkevqeriea lsstdsflie kvdfpsnkig 301 ssasdyesdn eyrnmdedsi ndvttekegn vvipdsntst vdamekpiev ssalkddtld 361 kdiddasssy sddvettfep veseelsdls dtsssgsski ytiptfrglt nrtnisqils 421 kvgkadlsqd nlthlikshq kkkrcvnfrn krfydafnpy vdneedaels dsenisemdt 481 dlcikdrsts svrfdensrl liykkskkln kdetqsgyst temrsilktk mnsqhdeesq 541 raskcdtvgv aqflhyfqyt eykrqrneae nyrlrgeqls kyyseeypld faavecedsv 601 ndksdiilsm raternigrq lkgissqgaq iisldedvf // LOCUS NP_009602 334 aa linear PLN 30-JUN-2025 DEFINITION NADPH:quinone reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009602 VERSION NP_009602.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178394.1 REFERENCE 1 (residues 1 to 334) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 334) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 334) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 334) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07166. Method: conceptual translation. FEATURES Location/Qualifiers source 1..334 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..334 /product="NADPH:quinone reductase" /EC_number="1.6.5.5" /calculated_mol_wt="36888" Region 10..332 /region_name="QOR2" /note="Quinone oxidoreductase (QOR); cd05286" /db_xref="CDD:176189" Site order(48..49,53,131,135,138,156,159..161,180..181,185,200, 224..225,246..250,270..273,320,322) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:176189" Site order(143,239..240,253..258,265..272,275..276) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:176189" CDS 1..334 /gene="ZTA1" /locus_tag="YBR046C" /coded_by="NM_001178394.1:1..1005" /experiment="EXISTENCE:direct assay:GO:0003960 quinone reductase (NADPH) activity [PMID:17497241]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032440 2-alkenal reductase [NAD(P)H] activity [PMID:21276778]" /experiment="EXISTENCE:direct assay:GO:0035925 mRNA 3'-UTR AU-rich region binding [PMID:17497241|PMID:19007762]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17497241]" /note="NADPH-dependent quinone reductase; GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin" /db_xref="GeneID:852335" /db_xref="SGD:S000000250" ORIGIN 1 mkctipeqqk vilideiggy dvikyedypv psiseeelli knkytgvnyi esyfrkgiyp 61 cekpyvlgre asgtvvakgk gvtnfevgdq vayisnstfa qyskissqgp vmklpkgtsd 121 eelklyaagl lqvltalsft neayhvkkgd yvllfaaagg vglilnqllk mkgahtiava 181 stdeklkiak eygaeylina skedilrqvl kftngkgvda sfdsvgkdtf eislaalkrk 241 gvfvsfgnas glippfsitr lspknitlvr pqlygyiadp eewkyysdef fglvnskkln 301 ikiyktyplr dyrtaaadie srktvgklvl eipq // LOCUS NP_009603 175 aa linear PLN 30-JUN-2025 DEFINITION Fmp23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009603 VERSION NP_009603.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178395.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 175) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07167. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..175 /product="Fmp23p" /calculated_mol_wt="20382" Region 53..175 /region_name="FMP23" /note="Found in mitochondrial proteome; pfam17315" /db_xref="CDD:435858" CDS 1..175 /gene="FMP23" /locus_tag="YBR047W" /coded_by="NM_001178395.1:1..528" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14562095|PMID:14576278]" /note="hypothetical protein; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:852336" /db_xref="SGD:S000000251" ORIGIN 1 mlinhlskir tvrhfsnikp vlskevsrrv ivapashfkt sspnvksnip iheykqlped 61 snyiekhyke lqvflnefli kklnktyadf egdpdelvfq lekfielevt prytnhsapd 121 gceerfksig drivvdryld fvkdvrltll lngghsfifd vmlqakevfd kmqke // LOCUS NP_009604 156 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS17 RPS11B [Saccharomyces cerevisiae S288C]. ACCESSION NP_009604 VERSION NP_009604.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178396.1 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 156) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07168. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..156 /product="40S ribosomal protein uS17 RPS11B" /calculated_mol_wt="17618" Region 4..156 /region_name="PTZ00241" /note="40S ribosomal protein S11; Provisional" /db_xref="CDD:240326" CDS 1..156 /gene="RPS11B" /locus_tag="YBR048W" /coded_by="NM_001178396.1:1..471" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:8070651]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; RPS11B has a paralog, RPS11A, that arose from the whole genome duplication" /db_xref="GeneID:852337" /db_xref="SGD:S000000252" ORIGIN 1 msteltvqse rafqkqphif nnpkvktskr tkrwyknagl gfktpktaie gsyidkkcpf 61 tglvsirgki ltgtvvstkm hrtivirray lhyipkynry ekrhknvpvh vspafrvqvg 121 divtvgqcrp isktvrfnvv kvsaaagkan kqfakf // LOCUS NP_009605 810 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding protein REB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009605 VERSION NP_009605.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178397.1 REFERENCE 1 (residues 1 to 810) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 810) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 810) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 810) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07169. Method: conceptual translation. FEATURES Location/Qualifiers source 1..810 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..810 /product="DNA-binding protein REB1" /calculated_mol_wt="91744" Region 202..701 /region_name="REB1" /note="Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]; COG5147" /db_xref="CDD:227476" CDS 1..810 /gene="REB1" /locus_tag="YBR049C" /gene_synonym="EBF1; GRF2" /coded_by="NM_001178397.1:1..2433" /experiment="EXISTENCE:direct assay:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:27601258]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:20852627]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:25479637|PMID:27601258]" /experiment="EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:27601258]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:27601258]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:25479637]" /note="RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; Reb1p bound to DNA acts to block RNA polymerase II readthrough transcription" /db_xref="GeneID:852338" /db_xref="SGD:S000000253" ORIGIN 1 mpsghndkna nqesveeavl kyvgvgldhq nhdpqlhtkd lenkhskkqn ivesssdvdv 61 nnnddsnrne dnnddsenis alnanesssn vdhansneqh navmdwylrq tahnqqdded 121 dennnntdng ndsnnhfsqs divvdddddk nkkdagvgvd ddhqsmamaa vaaaytlskn 181 nnnnnsiand snsrkrqhdn gnnhensqkk rknnnddddr qignvdpelt tlgdaddndt 241 nndvidrdql vhkaiidads itqhpdfqqy lntaadtddn eklkhikdhl mrthglnhqn 301 knhnddtddl snstkqysel qkdsmldssl nksrnymevl pkvisqdtqp hqqkspshdn 361 eagsvdnsei sqllqsaatk asslvslsss satpstsrsn nskafdkaed aalerfiney 421 eaierltrqq vceriwssdr pkdnfwnniy kvlpyrssss iykhmrrkyh ifeqrgkwta 481 eeeqelaklc aekegqwaei gktlgrmped crdrwrnyvk cgtnrasnrw sveeeellkk 541 visdmleeaq qqqsqlhpnl leeeqhllqd dqndhrnnde ddddtasaaa aaaaaiqeqq 601 qllqqkqqdd ddaiaaaaaa assslgdnkd edkphdslgi qlddnsqnsm vpapsatsth 661 skslsntirr hnnklrkslm gngkldfkdi inwtivserm ggtrsriqcr ykwnklvkre 721 aiakiqtvkd ddmlwifekl rdlgitedsq vdwdelaalk pgmklnglel klcyermkkk 781 vkgykqksin eiskelvdyf ssnismkten // LOCUS NP_009606 338 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase regulator REG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009606 VERSION NP_009606.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178398.1 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 338) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07170. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..338 /product="protein phosphatase regulator REG2" /calculated_mol_wt="38616" Region <133..153 /region_name="DUF1752" /note="Fungal protein of unknown function (DUF1752); pfam08550" /db_xref="CDD:430068" CDS 1..338 /gene="REG2" /locus_tag="YBR050C" /coded_by="NM_001178398.1:1..1017" /experiment="EXISTENCE:direct assay:GO:0019888 protein phosphatase regulator activity [PMID:8649403]" /experiment="EXISTENCE:mutant phenotype:GO:0071333 cellular response to glucose stimulus [PMID:10821175|PMID:8649403]" /experiment="EXISTENCE:mutant phenotype:GO:1904547 regulation of cellular response to glucose starvation [PMID:8649403]" /experiment="EXISTENCE:physical interaction:GO:0000164 protein phosphatase type 1 complex [PMID:8649403]" /note="Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease; REG2 has a paralog, REG1, that arose from the whole genome duplication" /db_xref="GeneID:852340" /db_xref="SGD:S000000254" ORIGIN 1 mtlsncdsld nlfqdppeee esskfveavr tlmnrndmgy ppaaangtyc lkkikslnak 61 qwkinkkrmc mlpavkkknf dfheqrslil nlnlwkfikf incssknnyn knnkhvrssn 121 ntvknenvlp lqkhkkvdnd qrlenlfwrs wfkarkrrdi mgkprerhik fndnveqcii 181 tdehfiqrlp strlnstdeq rpcskseldp cignaaskrs fydynsvyva sdaiittaaa 241 taiissnsgd yqrghdvrdv prnvllqage tdfssvlrvd sdlklsnish hspvkpssts 301 shstfifese tdtdtdtdae tendidayid tsipnlll // LOCUS NP_009608 210 aa linear PLN 30-JUN-2025 DEFINITION flavodoxin-like fold family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009608 VERSION NP_009608.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178400.1 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 210) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07171. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..210 /product="flavodoxin-like fold family protein" /calculated_mol_wt="22790" Region 1..201 /region_name="FMN_red" /note="NADPH-dependent FMN reductase; cl00438" /db_xref="CDD:469770" CDS 1..210 /gene="RFS1" /locus_tag="YBR052C" /coded_by="NM_001178400.1:1..633" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21442317|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:38096056]" /experiment="EXISTENCE:mutant phenotype:GO:0160020 positive regulation of ferroptosis [PMID:38096056]" /note="hypothetical protein; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; RFS1 has a paralog, PST2, that arose from the whole genome duplication" /db_xref="GeneID:852341" /db_xref="SGD:S000000256" ORIGIN 1 mpkvailiys vddiiatlae nekkgieiag geaeifqvpd vsykteyate egkeaakvak 61 tnadfsykil tretlveydy ylfgiptkfg nfpaewksfw dsntgglwak gslhgkiagl 121 fvsgaisgkg dtemcimnam stlvhhgviy vplgyknayk eltdvedvng scawgagcvs 181 gidggrppsl selrvhqlqg kafydrikdl // LOCUS NP_009609 358 aa linear PLN 30-JUN-2025 DEFINITION regucalcin [Saccharomyces cerevisiae S288C]. ACCESSION NP_009609 VERSION NP_009609.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178401.1 REFERENCE 1 (residues 1 to 358) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 358) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 358) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 358) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07172. Method: conceptual translation. FEATURES Location/Qualifiers source 1..358 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..358 /product="regucalcin" /calculated_mol_wt="40165" Region 27..318 /region_name="SGL" /note="SMP-30/Gluconolactonase/LRE-like region; pfam08450" /db_xref="CDD:462480" Region 150..186 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 199..248 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 259..294 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..358 /locus_tag="YBR053C" /coded_by="NM_001178401.1:1..1077" /note="hypothetical protein; induced by cell wall perturbation" /db_xref="GeneID:852342" /db_xref="SGD:S000000257" ORIGIN 1 mssvgdfeei ilhdlkpyyh vpgaihsegi tfvketgtll wvdifkgevh kvedieqpes 61 shsffsisra nygknasiey ppnpdelkes vgcifpildg asqneikqvl fgskfgigkl 121 dfskseweyv ilysecpels tdrayklrsn dgnvspdgky iyvglmsdfp fdlepigcll 181 rvdllahkie lvwncllipn aihwdesdqk tmyvtdslnf tiwkcpggdl lkrdelidvk 241 nsnnqsfesp epdgsaiwfs kdgkhsgflf itvwstskvq mfdltngkll kefilpeqtp 301 rvscccfvgk dlfvttanae indavrtntd knggciykip nvldgnvple stkrqplh // LOCUS NP_009610 344 aa linear PLN 30-JUN-2025 DEFINITION Yro2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009610 VERSION NP_009610.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178402.1 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 344) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07173. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..344 /product="Yro2p" /calculated_mol_wt="38589" Region 30..260 /region_name="7tm_YRO2_fungal-like" /note="fungal YRO2 and related proteins, member of the seven-transmembrane GPCR superfamily; cd15239" /db_xref="CDD:320367" Region 31..56 /region_name="TM helix 1" /note="TM helix 1 [structural motif]" /db_xref="CDD:320367" Region 62..84 /region_name="TM helix 2" /note="TM helix 2 [structural motif]" /db_xref="CDD:320367" Region 114..136 /region_name="TM helix 3" /note="TM helix 3 [structural motif]" /db_xref="CDD:320367" Site order(120,123..124,152,156,171,174..175,178,215,219..220, 223,245,248..249) /site_type="other" /note="putative ligand binding site [chemical binding]" /db_xref="CDD:320367" Region 140..160 /region_name="TM helix 4" /note="TM helix 4 [structural motif]" /db_xref="CDD:320367" Region 167..191 /region_name="TM helix 5" /note="TM helix 5 [structural motif]" /db_xref="CDD:320367" Region 198..226 /region_name="TM helix 6" /note="TM helix 6 [structural motif]" /db_xref="CDD:320367" Region 235..260 /region_name="TM helix 7" /note="TM helix 7 [structural motif]" /db_xref="CDD:320367" CDS 1..344 /gene="YRO2" /locus_tag="YBR054W" /coded_by="NM_001178402.1:1..1035" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25503505]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /note="Protein with a putative role in response to acid stress; null mutant is sensitive to acetic acid; transcription is regulated by Haa1p and induced in the presence of acetic acid; protein observed in plasma membrane foci in the presence of acetic acid; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:852343" /db_xref="SGD:S000000258" ORIGIN 1 msdyvellkr ggneaikinp ptgadfhits rgsdwlftvf cvnllfgvil vplmfrkpvk 61 drfvyytaia pnlfmsiayf tmasnlgwip vrakynhvqt stqkehpgyr qifyaryvgw 121 flafpwpiiq msllggtplw qiafnvgmte iftvcwliaa cvhstykwgy ytigigaaiv 181 vcislmtttf nlvkargkdv snvfitfmsv imflwliayp tcfgitdggn vlqpdsatif 241 ygiidllils ilpvlfmpla nylgierlgl ifdeepaehv gpvaekkmps pasfkssdsd 301 ssikeklklk kkhkkdkkka kkakkakkak kaqeeeedva tdse // LOCUS NP_009611 899 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit PRP6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009611 VERSION NP_009611.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178403.1 REFERENCE 1 (residues 1 to 899) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 899) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 899) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 899) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07174. Method: conceptual translation. FEATURES Location/Qualifiers source 1..899 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..899 /product="U4/U6-U5 snRNP complex subunit PRP6" /calculated_mol_wt="104099" Region 11..131 /region_name="PRP1_N" /note="PRP1 splicing factor, N-terminal; pfam06424" /db_xref="CDD:461908" Region 201..>370 /region_name="COG5191" /note="Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat [General function prediction only]" /db_xref="CDD:227518" Region 630..855 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 634..662 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 668..696 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(669,672..673,676..677,679,703,706..707,710..711, 714..715,738,741..742,745..746,749) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 701..732 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 737..765 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 770..800 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 805..833 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..899 /gene="PRP6" /locus_tag="YBR055C" /gene_synonym="RNA6; TSM7269" /coded_by="NM_001178403.1:1..2700" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /note="Splicing factor; component of the U4/U6-U5 snRNP complex" /db_xref="GeneID:852344" /db_xref="SGD:S000000259" ORIGIN 1 merpsfldqe ppagyvpgig rgatgfstke kqvvsnddkg rripkryren lnnhlqsqpk 61 ddeddeaanv fktlelklaq kkkkranekd ddnsvdssnv krqfadlkes laavtesewm 121 dipdatdftr rnkrnriqeq lnrktyaapd slipgnvdln klteerekll qsqidenlaq 181 ltknasnpiq vnkpnaatda lsylkdlend rvnslsdatl edlqkmrtil ksyrkadptn 241 pqgwiasarl eekarkfsva kkiiengcqe cprssdiwle nirlhesdvh ycktlvatai 301 nfnptspllw fkaidlestt vnkyrvvrka lqeiprdegl wklavsfead kaqvikmlek 361 atqfipqsmd lltaytnlqs yhnakmtlns frkilpqepe iwiistllee rnnpdipvdk 421 lvsllkegll elskngykat lsawlkraea lndapnsnlt cqaivyaile wlresgeyes 481 elnnvdqile kmphskvqia vlkkliqwdp cdtvlwsrlk matesyhkie ellaffqell 541 fqtknsddir anmrekspgl lmmyvseywk aqkgdtrqtl vlidqiidfa phnldlrffk 601 ikllgrslql delrdffqqt fssledfkis gterlyykyv nflryqdlne eaikflnerc 661 lksfpichkf flqlgqiyhs mgniemsret ylsgtrlvpn cpllwvslsk ideidlknpv 721 rarsildrgl lknpddvlfy iakiqmeirl gnldqaellv tqalqkfpsn allwveqikl 781 fkhgnksslk ktifqdalrr tqndhrvlle igvsfyaeaq yetslkwler alkkcsrygd 841 twvwlfrtya rlgkdtvdly nmfdqcepty gpewiaaskn vkmqyctpre illrlmndk // LOCUS NP_009612 501 aa linear PLN 30-JUN-2025 DEFINITION 17-beta-hydroxysteroid dehydrogenase-like protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009612 VERSION NP_009612.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178404.1 REFERENCE 1 (residues 1 to 501) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 501) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 501) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 501) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07175. Method: conceptual translation. FEATURES Location/Qualifiers source 1..501 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..501 /product="17-beta-hydroxysteroid dehydrogenase-like protein" /calculated_mol_wt="57691" Region 105..390 /region_name="BglC" /note="Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism]; COG2730" /db_xref="CDD:442036" CDS 1..501 /gene="MRX18" /locus_tag="YBR056W" /coded_by="NM_001178404.1:1..1506" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="Putative glycoside hydrolase of the mitochondrial intermembrane space" /db_xref="GeneID:852346" /db_xref="SGD:S000000260" ORIGIN 1 migslrnkfe hfkvsekggq nlsttlpklp pakdldrsti ykyrynygvn lgalfvlepw 61 ifsketicti dgkeydsefd aisqqlkkhs sedvakmlsd hykkyidrid wewlskdahi 121 talripigyw hvedgkhlds lpfaplrkvy elakpweklg elinnakkms igvlidlhgl 181 pggancdshs gsksgeaaff hkekymtkvy kdilpaiint mtlgneniig iqvvneacfd 241 nnpkgqkfyy seaintvekl qpglpviisd gwwpqqwadw vkekhfseiv vidshvyrcf 301 sdsdkskdan siikdlpntv nfphedadyt vgefsgvldg qtwnktsgdr daivqkyvqt 361 qadvfshvas wgwffwtlqf eygdggewgl apmmqkgnlp krphgddlqv dkkkidsiih 421 eheaywngkg knfehwrfed giktavddii afrkfdnsli grwhswksqr raeyvsakkd 481 sefmwewdqg yqrgldefnk y // LOCUS NP_001257668 66 aa linear PLN 30-JUN-2025 DEFINITION Mnc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257668 VERSION NP_001257668.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270739.1 REFERENCE 1 (residues 1 to 66) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 66) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 66) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 66) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35094. Method: conceptual translation. FEATURES Location/Qualifiers source 1..66 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..66 /product="Mnc1p" /calculated_mol_wt="7197" CDS 1..66 /gene="MNC1" /locus_tag="YBR056W-A" /coded_by="NM_001270739.1:1..201" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:37239347]" /note="Putative membrane protein; upregulated by toxic concentrations of heavy metal ions including Mn2+, Co2+, Ni2+, Cu2+, and Zn2+; mRNA identified as translated by ribosome profiling data; localizes to the cytoplasm, possibly in intracellular membranes; CYSTM (cysteine-rich transmembrane module) family member; partially overlaps dubious ORF YBR056C-B; YBR056W-A has a paralog, YDR034W-B, that arose from the whole genome duplication" /db_xref="GeneID:1466443" /db_xref="SGD:S000028736" ORIGIN 1 mrhqyyqpqp myyqpqpqpi yiqqgppppr ndcccccncg dccsaianvl cclclidlcc 61 scaggm // LOCUS NP_009613 366 aa linear PLN 30-JUN-2025 DEFINITION Mum2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009613 VERSION NP_009613.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178405.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 366) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07176. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..366 /product="Mum2p" /calculated_mol_wt="41302" Region 189..356 /region_name="Wtap" /note="WTAP/Mum2p family; pfam17098" /db_xref="CDD:465345" CDS 1..366 /gene="MUM2" /locus_tag="YBR057C" /coded_by="NM_001178405.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:22685417]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:9504908]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:22685417]" /experiment="EXISTENCE:mutant phenotype:GO:2000221 negative regulation of pseudohyphal growth [PMID:22685417]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:22685417]" /experiment="EXISTENCE:physical interaction:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:22685417]" /note="Protein essential for meiotic DNA replication and sporulation; cytoplasmic protein; subunit of the MIS complex which controls mRNA methylation during during the induction of sporulation; also interacts with Orc2p, which is a component of the origin recognition complex" /db_xref="GeneID:852348" /db_xref="SGD:S000000261" ORIGIN 1 mnymaydydp qhsletsfnn lafhphqqsq qqalyesger ndarpglmnt lgqaskmnns 61 mlpqgssasp ltgqhslnst tnfnmppsmn tynyqnvpqa smrntlnhnn imngatandy 121 wldpmnnmtn nkdtngnpnd smssmsnmta ktsinstafk nsfvpfnhvt alsmnnvnsn 181 emnsnkddrm ealevelqik esqieslene iqrlkkifne glnykqnehk yekenchipq 241 tfelpaslev ifrklssslh akekelaetk enlesiltal alnptnsvtk ygrydaesia 301 hkmvvrlenl tnenkemakm laygrsketq ielqlakken lelrekiasl eahlaskess 361 kedvan // LOCUS NP_009614 781 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease UBP14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009614 VERSION NP_009614.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178406.1 REFERENCE 1 (residues 1 to 781) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 781) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 781) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 781) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 781) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 781) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 781) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07177. On Oct 2, 2003 this sequence version replaced NP_009614.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..781 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..781 /product="ubiquitin-specific protease UBP14" /EC_number="3.4.19.12" /calculated_mol_wt="88499" Region 9..84 /region_name="zf-UBP_var" /note="Variant UBP zinc finger; pfam17807" /db_xref="CDD:407678" Region 192..259 /region_name="zf-UBP" /note="Zn-finger in ubiquitin-hydrolases and other protein; pfam02148" /db_xref="CDD:460464" Region 324..778 /region_name="Peptidase_C19B" /note="A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02658" /db_xref="CDD:239123" Site order(327,332,737,757) /site_type="active" /db_xref="CDD:239123" Region 587..633 /region_name="UBA_like_SF" /note="UBA domain-like superfamily; cl21463" /db_xref="CDD:473871" Region 652..689 /region_name="UBA2_scUBP14_like" /note="UBA2 domain found in Saccharomyces cerevisiae ubiquitin carboxyl-terminal hydrolase 14 (scUBP14) and similar proteins; cd14298" /db_xref="CDD:270484" CDS 1..781 /gene="UBP14" /locus_tag="YBR058C" /gene_synonym="GID6" /coded_by="NM_001178406.1:1..2346" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:8982460]" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:19410548]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]" /note="Ubiquitin-specific protease; specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T" /db_xref="GeneID:852349" /db_xref="SGD:S000000262" ORIGIN 1 maeavlenvn vpavvskdec iycfespyne plalnaspkh slniclncfq atcnrhvplh 61 irvteyacdt ihsnyltiak vekpkqenve ennnnkkikl qvietseddt hntiwslqrf 121 ngenvprtvl skstdsdiss talekiekil kaksqdfedk knswvleist cphtenfqip 181 skpentvnln qcsscdltqn lwlclhcgni gcgreqigid ghshaldhyr snnnhplaik 241 lgslssstyd lycyacddet rfpdnvnlgs alqiyginiq ekiadektlv qlqveqnenw 301 qfrmvdssgk efeklsaskn ygcglinlgn scylnsviqs lvnggvpnws ldflgskfpl 361 dvvypdnnlk cqwikllnam kcepelypng ikpttfkkci gqnhqefssn rqqdameflt 421 flldlldkkf fsssssgipn pndlvrfmme drlqcnicgk vkysyeptea iqipleende 481 pqdmlerika yfegqtiefk canckekvta nkkpgfkslp qtlilnpiri rlqnwipvkt 541 snelslpgli drddmldvss ylsqgfdpqt enllpdeden rssftpnqcs isqliemgft 601 qnasvralfn tgnqdaesam nwlfqhmddp dlndpfvppp nvpkkdkrev devsltsmls 661 mglnpnlcrk alilnngdvn rsvewvfnnm dddgtfpepe vpneeqqqkk dlgystakpy 721 altavichkg nsvhsghyvv firklvadkw kwvlyndekl vaadsiedmk kngyiyfytr 781 c // LOCUS NP_116327 80 aa linear PLN 30-JUN-2025 DEFINITION Tsc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116327 VERSION NP_116327.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184442.3 REFERENCE 1 (residues 1 to 80) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 80) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 80) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 80) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07178. On Jul 30, 2012 this sequence version replaced NP_116327.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..80 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..80 /product="Tsc3p" /calculated_mol_wt="9448" CDS 1..80 /gene="TSC3" /locus_tag="YBR058C-A" /coded_by="NM_001184442.3:1..243" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:10713067]" /experiment="EXISTENCE:direct assay:GO:0017059 serine palmitoyltransferase complex [PMID:20182505]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:10713067]" /experiment="EXISTENCE:mutant phenotype:GO:0090154 positive regulation of sphingolipid biosynthetic process [PMID:23286903|PMID:10713067]" /experiment="EXISTENCE:physical interaction:GO:0006666 3-keto-sphinganine metabolic process [PMID:10713067]" /note="Protein that stimulates the activity of serine palmitoyltransferase; involved in sphingolipid biosynthesis; Lcb1p and Lcb2p are the two components of serine palmitoyltransferase" /db_xref="GeneID:852350" /db_xref="SGD:S000007521" ORIGIN 1 mtqhkssmvy ipttkeakrr ngksegilnt ieevveklyw tyyihlpfyl masfdsfflh 61 vffltifsls ffgilkycfl // LOCUS NP_009615 1108 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase AKL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009615 VERSION NP_009615.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178407.1 REFERENCE 1 (residues 1 to 1108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1108) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07179. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1108 /product="serine/threonine protein kinase AKL1" /EC_number="2.7.11.1" /calculated_mol_wt="123859" Region 31..322 /region_name="STKc_NAK_like" /note="Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; cd14037" /db_xref="CDD:270939" Site order(41..45,49,76,78,108,131..134,138,140,181,183, 185..186,188,199,202,227..230) /site_type="active" /db_xref="CDD:270939" Site order(41..45,49,76,78,108,131..134,138,181,183,185..186, 188,199) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270939" Site order(45,138,140,181,183,185,202,227..230) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270939" Site order(198..212,214..230) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270939" CDS 1..1108 /gene="AKL1" /locus_tag="YBR059C" /coded_by="NM_001178407.1:1..3327" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:29895620|PMID:12956961]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:29895620]" /experiment="EXISTENCE:mutant phenotype:GO:1900186 negative regulation of clathrin-dependent endocytosis [PMID:28069741|PMID:17178891|PMID:29895620]" /note="Ser/Thr protein kinase; phosphorylates Pan1p, Sla1p and Ent1p to negatively regulate endocytosis in response to membrane stress; regulates actin cytoskeleton organization and clathrin-dependent endocytosis; phosphorylated and inhibited by upstream kinase, Fpk1p; member, along with Ark1p and Prk1p, of the Ark kinase family" /db_xref="GeneID:852351" /db_xref="SGD:S000000263" ORIGIN 1 msitngtsrs vsamghpave rytpghivcv gthkvevvny laeggfaqiy vvkfleylne 61 fdntasvplk igdvaclkrv lvqdenglne mrnevevmkk lkgapnivqy fdsnasrrrd 121 gvqgfevlll melcpnksll dymnqrlstk lteaeivkim ydvalsisqm hylpvslihr 181 dikienvlvd aknnfkladf gststcfpiv tthqdiallt qniyvhttpq yrspemidly 241 rclpineksd iwalgvflyk llffttpfem tgqfailhsk yefpvnkyss klinliiiml 301 aenpnlrpni yqvlyhlcei lnvevpiedk yaegaynfsk ytqfqnklqn vqlqmyqlqq 361 kkimqnnkls dseenllndm flssfeissk lpmnasdgha avsripsqnv gqeleeekes 421 qsdqrkstls edkssrttsn anssgtannp qeintiqspg iedksifenk tpgelyypsv 481 seldtyldke lvkqssdpti seqsprlntq slpqrqksts syssggrsmk stsygaatig 541 sdealanekt aginkmkqhk snnpfpkmnv ayhstnelsn dasnffleeq qqgqryqqaq 601 nqtgtqgntf pdesqyqsrv eqqqqqqdqp kgpanysqrn fytgrdrsnk pmqlggtiag 661 dsgnrrvnfq nisqnyatns qsgylpsqns paipmvrpvi smnqqqaqqi qaqqlqaqqm 721 qakqqmqakq qmqvqqqlqv qqqmqiqnan nngtyvsdrt nhttedmrna qggeppilag 781 nsanepmhss sknealliel splkedagkq sfqdtnepqt ggiedaggsg tikgsnnnrn 841 gvlnlslnem dlsrddtgaa vssfssssss asiqqaklsg rkgsskrnny stdelgdsmv 901 ssesididld darrgktaer rplhnerghk dqarssdask snqfkskdfs svstrqprqs 961 ldlnfqevnl ssptltqehr nkndspapns hhsyrvspha staitenkrh stghelstrs 1021 ngkhethrtg skqrhdlery rhskdkdsns sitiststps emrksfarar qsldlervrr 1081 eamassasss ggsngkrrsf fsvfrsek // LOCUS NP_009616 620 aa linear PLN 30-JUN-2025 DEFINITION origin recognition complex subunit 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009616 VERSION NP_009616.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178408.1 REFERENCE 1 (residues 1 to 620) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 620) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 620) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 620) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07180. Method: conceptual translation. FEATURES Location/Qualifiers source 1..620 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..620 /product="origin recognition complex subunit 2" /calculated_mol_wt="71107" Region 24..620 /region_name="ORC2" /note="Origin recognition complex, subunit 2 [DNA replication, recombination, and repair]; COG5575" /db_xref="CDD:227862" CDS 1..620 /gene="ORC2" /locus_tag="YBR060C" /gene_synonym="RRR1; SIR5" /coded_by="NM_001178408.1:1..1863" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:9159120|PMID:9288745]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194|PMID:9288745]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:9335335|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:7579692]" /experiment="EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16716188|PMID:7579692]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16980387]" /note="Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p" /db_xref="GeneID:852352" /db_xref="SGD:S000000264" ORIGIN 1 mlngedfveh ndilsspaks rnvtpkrvdp hgerqlrrih sskknlleri slvgnerknt 61 spdpalkpkt pskaprkrgr prkiqeeltd rikkdekdti sskkkrkldk dtsgnvnees 121 ktsnnkqvme ktgikekrer ekiqvattty ednvtpqtdd nfvsnspepp epatpskksl 181 ttnhdftspl kqiimnnlke ykdstspgkl tlsrnftptp vpknkklyqt setksassfl 241 dtfegyfdqr kivrtnaksr htmsmapdvt reefslvsnf fnenfqkrpr qklfeiqkkm 301 fpqywfeltq gfsllfygvg skrnfleefa idylspkiay sqlayenelq qnkpvnsipc 361 lilngynpsc nyrdvfkeit dllvpaeltr setkywgnhv ilqiqkmidf yknqpldikl 421 ilvvhnldgp sirkntfqtm lsflsvirqi aivastdhiy apllwdnmka qnynfvfhdi 481 snfepstves tfqdvmkmgk sdtssgaega kyvlqsltvn skkmykllie tqmqnmgnls 541 antgpkrgtq rtgvelklfn hlcaadfias neialrsmlr efiehkmani tknnsgmeii 601 wvpytyaele kllktvlntl // LOCUS NP_009617 310 aa linear PLN 30-JUN-2025 DEFINITION tRNA methyltransferase TRM7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009617 VERSION NP_009617.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178409.3 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 310) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07181. On Jul 30, 2012 this sequence version replaced NP_009617.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..310 /product="tRNA methyltransferase TRM7" /EC_number="2.1.1.205" /calculated_mol_wt="34570" Region 3..209 /region_name="RlmE" /note="23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]; COG0293" /db_xref="CDD:440062" CDS 1..310 /gene="TRM7" /locus_tag="YBR061C" /coded_by="NM_001178409.3:1..933" /experiment="EXISTENCE:direct assay:GO:0002128 tRNA nucleoside ribose methylation [PMID:11927565]" /experiment="EXISTENCE:direct assay:GO:0002130 wobble position ribose methylation [PMID:11927565]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11927565]" /experiment="EXISTENCE:direct assay:GO:0106050 tRNA 2'-O-methyltransferase activity [PMID:11927565]" /experiment="EXISTENCE:mutant phenotype:GO:0002130 wobble position ribose methylation [PMID:22912484]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:11927565]" /note="2'-O-ribose methyltransferase; methylates the 2'-O-ribose of tRNA-Phe, tRNA-Trp, and tRNA-Leu at positions C32 and N34 of tRNA anticodon loop; crucial biological role likely modification of tRNA-Phe; interacts with Trm732p and Rtt10p in 2'-O-methylation of C32 and N34 substrate tRNAs, respectively; yeast null mutant can be functionally complemented by human FTSJ1, mutations in which have been implicated in nonsyndromic X-linked intellectual disability (NSXLID)" /db_xref="GeneID:852353" /db_xref="SGD:S000000265" ORIGIN 1 mgksskdkrd lyyrkakeqg yrarsafkll qlndqfhfld dpnlkrvvdl caapgswsqv 61 lsrklfdesp ssdkedrkiv svdlqpmspi phvttlqadi thpktlaril klfgnekadf 121 vcsdgapdvt glhdldeyvq qqlimsalql tacilkkggt fvakifrgrd idmlysqlgy 181 lfdkivcakp rssrgtslea fivclgynpp snwtpkldvn tsvdeffqgc flnklcisdk 241 lshwneeern iaefmacgsl qsfdsdatyh dlpssvagts ssldpvqspt nppykkalel 301 krsgkltrsv // LOCUS NP_009618 180 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR062C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009618 VERSION NP_009618.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178410.1 REFERENCE 1 (residues 1 to 180) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 180) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 180) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 180) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07182. On Jul 26, 2004 this sequence version replaced NP_009618.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..180 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..180 /product="uncharacterized protein" /calculated_mol_wt="20465" Region 109..153 /region_name="RING_Ubox" /note="RING finger (Really Interesting New Gene) domain and U-box domain superfamily; cl17238" /db_xref="CDD:473075" Site order(109,112,130,132,135,138,149,152) /site_type="other" /note="cross-brace motif" /db_xref="CDD:438128" CDS 1..180 /locus_tag="YBR062C" /coded_by="NM_001178410.1:1..543" /note="hypothetical protein that interacts with Msb2p; may play a role in activation of the filamentous growth pathway" /db_xref="GeneID:852354" /db_xref="SGD:S000000266" ORIGIN 1 mstyeeehgi qqnsrdyqev ggtsqeeqrr qvrsqlqglf qnfgntsgeg dahsdstlll 61 rllsqmlpes lqeewlqemd kgksagcpdt faaslprink kklkatdncs icytnylede 121 yplvvelphc hhkfdlecls vwlsrsttcp lcrdnvmghr iineidttea eleedwgmyg // LOCUS NP_009619 404 aa linear PLN 30-JUN-2025 DEFINITION Cnm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009619 VERSION NP_009619.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178411.1 REFERENCE 1 (residues 1 to 404) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 404) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 404) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 404) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07183. Method: conceptual translation. FEATURES Location/Qualifiers source 1..404 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..404 /product="Cnm1p" /calculated_mol_wt="46314" CDS 1..404 /gene="CNM1" /locus_tag="YBR063C" /coded_by="NM_001178411.1:1..1215" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:34694322]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:34694322]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:34694322]" /experiment="EXISTENCE:direct assay:GO:0044232 organelle membrane contact site [PMID:34694322]" /experiment="EXISTENCE:direct assay:GO:0140056 organelle localization by membrane tethering [PMID:34694322]" /note="Molecular tether on nuclear membrane; mediates contact by interacting with Tom70p on mitochondria; protein abundance is regulated by phosphatidylcholine, enabling coupling of phospholipid homeostasis with contact extent" /db_xref="GeneID:852356" /db_xref="SGD:S000000267" ORIGIN 1 meelglkstf pyeygsdftm irtemlnttk settilfsni ksilaiiwky sftflrsfsd 61 sikliiddvv tigsrnfaer lqieakknnd qediwastii lgviigylis sikrkntfpi 121 mptsspkidd crfktgdtis ivinfnedcl nnrsdvteer nyeestvlhs kesvlsigrq 181 nmvtlnqsde nftygnfdey dlltkdytte vltrspgsnp efkavvnntl ldsanetpfk 241 gieksinetm vkvpmgcdvs lshygrqyap gnisimrsft ardntksvsr eirdicksfl 301 iiksqfgdel fltmfmekpv ffdnnipiei tgayrekrer ldevihkdli rydevqnltr 361 irnllrvksq kicsrrhnss vptkkllvnd kgatsillwy snys // LOCUS NP_009621 364 aa linear PLN 30-JUN-2025 DEFINITION Pre-mRNA-splicing factor ECM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009621 VERSION NP_009621.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178413.3 REFERENCE 1 (residues 1 to 364) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 364) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 364) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 364) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07184. On Jul 30, 2012 this sequence version replaced NP_009621.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..364 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..364 /product="Pre-mRNA-splicing factor ECM2" /calculated_mol_wt="40794" Region 201..295 /region_name="RRM_SLT11" /note="RNA recognition motif (RRM) found in pre-mRNA-splicing factor SLT11 and similar proteins; cd12265" /db_xref="CDD:409709" CDS 1..364 /gene="ECM2" /locus_tag="YBR065C" /gene_synonym="SLT11" /coded_by="NM_001178413.3:1..1095" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:33547186]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:9528778]" /note="Pre-mRNA splicing factor; facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p" /db_xref="GeneID:852357" /db_xref="SGD:S000000269" ORIGIN 1 mndeineppp niceqclgde anirmtkipq gseckictlp ftlyhfktsk rsnniiktli 61 cvrcatqrni cqccmldsrw hipiqlrdhl islvneenvm teeakndmmk rflslknvkl 121 ggaqitsdps eadnivdklk nillratsdg pstplikntt alyknekgan evknlekyas 181 vdishilkkl plnesflknp stksfflyni dasipewkit dtvsqllgik kwkdgnslsl 241 ivnhkakcgg lrfqsselge rfvskisetl vtpkglkrgv llidrfrifi ipwssgfsaa 301 sfgtntaeni klslslnkli qlelglsfpt kstdnakndk kktskkvhkd rskkskpran 361 klti // LOCUS NP_009622 220 aa linear PLN 30-JUN-2025 DEFINITION Nrg2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009622 VERSION NP_009622.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178414.1 REFERENCE 1 (residues 1 to 220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 220) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07185. Method: conceptual translation. FEATURES Location/Qualifiers source 1..220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..220 /product="Nrg2p" /calculated_mol_wt="24878" Region <72..>220 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 155..175 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 183..205 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..220 /gene="NRG2" /locus_tag="YBR066C" /coded_by="NM_001178414.1:1..663" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:20802496]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15466424|PMID:16278455|PMID:12024013]" /experiment="EXISTENCE:genetic interaction:GO:0043709 cell adhesion involved in single-species biofilm formation [PMID:12024013]" /experiment="EXISTENCE:genetic interaction:GO:2000218 negative regulation of invasive growth in response to glucose limitation [PMID:15466424|PMID:12024013]" /experiment="EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:12024013]" /note="Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; activated in stochastic pulses of nuclear localization in response to low glucose" /db_xref="GeneID:852358" /db_xref="SGD:S000000270" ORIGIN 1 msigykdnlm stilakdrkc efpinfecsp sqitlmpemf sfnnerkyqt liplmktshl 61 idddlkdkln kcafdffsgk qanrtsdgti srltasgkts pilplqnini vkaentgngk 121 sdpyssikis kptktviklk stktntagqr trhfckicst gfttsghlsr hnrihtgekn 181 hicphegcgq rfsrhdncnq hyrthankkk rnwkrreass // LOCUS NP_009623 210 aa linear PLN 30-JUN-2025 DEFINITION putative lipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009623 VERSION NP_009623.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178415.1 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 210) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07186. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..210 /product="putative lipase" /calculated_mol_wt="20597" Region 15..108 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..210 /gene="TIP1" /locus_tag="YBR067C" /coded_by="NM_001178415.1:1..633" /experiment="EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:10216230]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460|PMID:10216230]" /experiment="EXISTENCE:direct assay:GO:0016298 lipase activity [PMID:9818717]" /experiment="EXISTENCE:direct assay:GO:0031505 fungal-type cell wall organization [PMID:10216230]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins" /db_xref="GeneID:852359" /db_xref="SGD:S000000271" ORIGIN 1 msvskiafvl saiaslavad tsaaetaelq aiigdinshl sdylgletgn sgfqipsdvl 61 svyqqvmtyt ddayttlfse ldfdaitkti vklpwyttrl sseiaaalas vspasseaas 121 sseaassska assseatssa apsssaapss saapsssaes sskavsssva pttssvstst 181 vetasnagqr vnagaasfga vvagaaalll // LOCUS NP_009624 609 aa linear PLN 30-JUN-2025 DEFINITION branched-chain amino acid permease BAP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009624 VERSION NP_009624.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178416.4 REFERENCE 1 (residues 1 to 609) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 609) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 609) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 609) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07187. On Jul 30, 2012 this sequence version replaced NP_009624.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..609 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..609 /product="branched-chain amino acid permease BAP2" /calculated_mol_wt="67639" Region 92..573 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..609 /gene="BAP2" /locus_tag="YBR068C" /coded_by="NM_001178416.4:1..1830" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0006865 amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015171 amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:10654085]" /note="High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication" /db_xref="GeneID:852360" /db_xref="SGD:S000000272" ORIGIN 1 mlssedfgss gkketspdsi sirsfsagnn fqssssekty skqksgsdkl ihrfadsfkr 61 aegsttrtkq inentsdled gvesitsdsk lkksmksrhv vmmslgtgig tgllvanakg 121 lhyggpaali igyilvsfvt yfmiqaagem avtyptlpan fnayssifis ksfgfatvwl 181 ycfqwltvlp lelitasmti qfwndkinpd iyilifyvfl vfihffgvka ygetefifnc 241 ckilmiagfi ilsivincgg agndgyigat ywhnpgafag dtsigrfknv cyilvtayfs 301 fggmelfals vqeqsnprks tpvaakrsiy rivviylltm iligfnvpyn ddqlmgaggs 361 athaspyvla asihgvkivp hiinavilis vvsvanssly agprlicsla qqgyapkfld 421 yvdregrplr alivccvfgv iafvaasske eivftwlaai aglselftwt simlshlrfr 481 qamkvqgrsl delgykattg iwgsiygvff nilvfvaqfw valaplgngg kcdaesffqn 541 ylafpiwlaf yfgymvynrd ftllnpldki dldfhrriyd pelmrqedee nkeklrnmsl 601 mrkayhfwc // LOCUS NP_009625 619 aa linear PLN 30-JUN-2025 DEFINITION amino acid transporter TAT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009625 VERSION NP_009625.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178417.1 REFERENCE 1 (residues 1 to 619) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 619) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 619) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 619) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07188. Method: conceptual translation. FEATURES Location/Qualifiers source 1..619 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..619 /product="amino acid transporter TAT1" /calculated_mol_wt="68627" Region 91..567 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..619 /gene="TAT1" /locus_tag="YBR069C" /gene_synonym="TAP1; VAP1" /coded_by="NM_001178417.1:1..1860" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23666621]" /experiment="EXISTENCE:direct assay:GO:0006865 amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015171 amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015827 tryptophan transport [PMID:7523855]" /experiment="EXISTENCE:genetic interaction:GO:0022893 low-affinity tryptophan transmembrane transporter activity [PMID:7523855]" /experiment="EXISTENCE:mutant phenotype:GO:0015828 tyrosine transport [PMID:7523855]" /note="Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852361" /db_xref="SGD:S000000273" ORIGIN 1 mddsvsfiak easpaqyshs lherthsekq krdftitekq devsgqtaep rrtdsksilq 61 rkckeffdsf krqlppdrns elesqeknnl tksiksrhlv mislgtgigt gllvgngqvl 121 gtagpaglvl gygiasimly ciiqaagelg lcyagltgny trypsilvdp slgfavsvvy 181 tiqwltvlpl qlvtaamtvk ywtsvnadif vavvfvfvii inlfgsrgya eaefifnsck 241 ilmvigfvil aiiincggag drryigaeyw hnpgpfahgf kgvctvfcya afsyggievl 301 llsaaeqenp tksipnackk vvyrilliym lttilvcflv pynsdellgs sdssgshasp 361 fviavashgv kvvphfinav ilisvisvan sslysgprll lslaeqgvlp kclayvdrng 421 rpllcffvsl vfgcigfvat sdaeeqvftw llaisslsql fiwmsmslsh irfrdamakq 481 grsmnevgyk aqtgywgswl avliaifflv cqfwvaiapv nehgklnvkv ffqnylampi 541 vlfayfghki yfkswsfwip aekidldshr nifvspslte idkvddnddl keyensesse 601 npnssrsrkf fkrmtnfwc // LOCUS NP_009626 237 aa linear PLN 30-JUN-2025 DEFINITION N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009626 VERSION NP_009626.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178418.1 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 237) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07189. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..237 /product="N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase anchoring subunit ALG14" /calculated_mol_wt="26904" Region 57..236 /region_name="Alg14" /note="Oligosaccharide biosynthesis protein Alg14 like; pfam08660" /db_xref="CDD:370045" CDS 1..237 /gene="ALG14" /locus_tag="YBR070C" /coded_by="NM_001178418.1:1..714" /experiment="EXISTENCE:direct assay:GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [PMID:16100113]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17686769|PMID:16100110]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:39025454]" /experiment="EXISTENCE:direct assay:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:16100113]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:15282802]" /experiment="EXISTENCE:mutant phenotype:GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [PMID:16100113|PMID:15615718]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:16100113|PMID:15615718]" /experiment="EXISTENCE:mutant phenotype:GO:0043495 protein-membrane adaptor activity [PMID:16100113|PMID:16100110]" /experiment="EXISTENCE:physical interaction:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:16100110]" /experiment="EXISTENCE:physical interaction:GO:0043541 UDP-N-acetylglucosamine transferase complex [PMID:16100110|PMID:16100113]" /note="Component of UDP-GlcNAc transferase; required for second step of dolichyl-linked oligosaccharide synthesis; anchors catalytic subunit Alg13p to ER membrane; localizes to the peroxisome; similar to bacterial and human glycosyltransferases; both human homologs ALG13 and ALG14 are required to complement yeast alg14 mutant; mutations of human ALG14 cause congenital myasthenic syndrome" /db_xref="GeneID:852362" /db_xref="SGD:S000000274" ORIGIN 1 mktaylaslv livstayvir liailpffht qagtekdtkd gvnllkirks skkplkifvf 61 lgsgghtgem irllenyqdl llgksivylg ysdeasrqrf ahfikkfghc kvkyyefmka 121 revkatllqs vktiigtlvq sfvhvvrirf amcgsphlfl lngpgtccii sfwlkimell 181 lpllgsshiv yveslarint psltgkilyw vvdefivqwq elrdnylprs kwfgilv // LOCUS NP_009627 211 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR071W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009627 VERSION NP_009627.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178419.3 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 211) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07190. On Jul 30, 2012 this sequence version replaced NP_009627.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..211 /product="uncharacterized protein" /calculated_mol_wt="23417" CDS 1..211 /locus_tag="YBR071W" /coded_by="NM_001178419.3:1..636" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276|PMID:21777356]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:21777356]" /note="hypothetical protein found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking" /db_xref="GeneID:852363" /db_xref="SGD:S000000275" ORIGIN 1 mlrrsknsst ntnadtkkrq smhlgskssl isltsefghg hsktkqkkee gtapsqflsp 61 tnkrstssqs klkrssllld etllkdyhsa mrhmqtnaak eeklrmapsp tqstrsesda 121 slsstkssis sifsqdndys ihdllyedie emdktdafki nntiaiddsk alfvfcsnds 181 ssrtasietl hesnldnldm gssrrtsldf f // LOCUS NP_009628 214 aa linear PLN 30-JUN-2025 DEFINITION chaperone protein HSP26 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009628 VERSION NP_009628.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178420.1 REFERENCE 1 (residues 1 to 214) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 214) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 214) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 214) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07191. Method: conceptual translation. FEATURES Location/Qualifiers source 1..214 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..214 /product="chaperone protein HSP26" /calculated_mol_wt="23749" Region 95..209 /region_name="IbpA" /note="Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]; COG0071" /db_xref="CDD:439841" CDS 1..214 /gene="HSP26" /locus_tag="YBR072W" /coded_by="NM_001178420.1:1..645" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2645298]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:2645298]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:10581247]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:24291094]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:10581247]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:10581247]" /note="Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic foci; oligomer activation requires heat-induced conformational change; also has mRNA binding activity" /db_xref="GeneID:852364" /db_xref="SGD:S000000276" ORIGIN 1 msfnspffdf fdninnevda fnrllgeggl rgyaprrqla ntpakdstgk evarpnnyag 61 alydprdetl ddwfdndlsl fpsgfgfprs vavpvdildh dnnyelkvvv pgvkskkdid 121 ieyhqnknqi lvsgeipstl neeskdkvkv kesssgkfkr vitlpdypgv dadnikadya 181 ngvltltvpk lkpqkdgknh vkkievssqe swgn // LOCUS NP_878048 53 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR072C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878048 VERSION NP_878048.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184540.1 REFERENCE 1 (residues 1 to 53) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 53) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 53) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 53) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07192. Method: conceptual translation. FEATURES Location/Qualifiers source 1..53 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..53 /product="uncharacterized protein" /calculated_mol_wt="6012" CDS 1..53 /locus_tag="YBR072C-A" /coded_by="NM_001184540.1:1..162" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /note="hypothetical protein; identified by fungal homology and RT-PCR; localizes to cytosol and peroxisomes" /db_xref="GeneID:1466444" /db_xref="SGD:S000028532" ORIGIN 1 mhiltrsskn afprsrsrqd ihisshihrd tsnsallkil vitrtrldsf vkt // LOCUS NP_009629 958 aa linear PLN 30-JUN-2025 DEFINITION DNA-dependent ATPase RDH54 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009629 VERSION NP_009629.6 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178421.4 REFERENCE 1 (residues 1 to 958) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 958) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 958) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 958) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07193. On Jul 30, 2012 this sequence version replaced NP_009629.5. Method: conceptual translation. FEATURES Location/Qualifiers source 1..958 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..958 /product="DNA-dependent ATPase RDH54" /EC_number="3.6.4.12" /calculated_mol_wt="107816" Region 108..>158 /region_name="DUF2439" /note="Protein of unknown function (DUF2439); pfam10382" /db_xref="CDD:463065" Region 296..573 /region_name="DEXHc_RAD54" /note="DEXH-box helicase domain of RAD54; cd18004" /db_xref="CDD:350762" Site order(348..354,404,472..473) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350762" Region 663..789 /region_name="SF2_C_SNF" /note="C-terminal helicase domain of the SNF family helicases; cd18793" /db_xref="CDD:350180" Site order(690..691,699,741,762..763) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:350180" Site order(747..748,750,773,776) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350180" CDS 1..958 /gene="RDH54" /locus_tag="YBR073W" /gene_synonym="TID1" /coded_by="NM_001178421.4:1..2877" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:16831867]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:16831867]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:10970884]" /experiment="EXISTENCE:direct assay:GO:0015616 DNA translocase activity [PMID:10970884]" /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:10970884]" /experiment="EXISTENCE:direct assay:GO:0032392 DNA geometric change [PMID:16831867|PMID:10970884]" /experiment="EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:16831867]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:16831867]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:16831867]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:9409820|PMID:9409819]" /experiment="EXISTENCE:mutant phenotype:GO:0008094 ATP-dependent activity, acting on DNA [PMID:16831867]" /experiment="EXISTENCE:mutant phenotype:GO:0032392 DNA geometric change [PMID:16831867]" /experiment="EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:16230461]" /note="DNA-dependent ATPase; DNA recombination/repair translocase, supercoils DNA, promotes DNA strand opening; stimulates strand exchange by modifying dsDNA topology; involved in recombinational repair of DNA double-strand breaks (DSBs) during mitosis, meiosis; implicated in cell divisions in telomerase-negative strains through adaptation to DNA damage, which allows bypass of cell cycle arrest and contributes senescence-specific genome instability; phosphorylated in response to DNA damage" /db_xref="GeneID:852365" /db_xref="SGD:S000000277" ORIGIN 1 mavisvkprr rekilqevkn ssvyqtvfds gttqmqipky enkpfkpprr vgsnkytqlk 61 ptatavttap iskakvtvnl krsisagptl nlakkpnnls snentryfti myrkpttkkh 121 ktwsgdgyat lkassdklcf yneagkflgs smlpsdsdsl fetlfkagsn evqldyelke 181 naeirsakea lsqnmgnpsp pttsttetvp stkndggkyq mplsqlfsln tvkrfksvtk 241 qtnehmttvp ktsqnskakk yypvfdvnki dnpivmnkna aaevdvivdp llgkflrphq 301 regvkfmydc lmglarptie npdidcttks lvlendsdis gclladdmgl gktlmsitli 361 wtlirqtpfa skvscsqsgi pltglckkil vvcpvtlign wkrefgkwln lsrigvltls 421 srnspdmdkm avrnflkvqr tyqvliigye kllsvseele knkhlidmlv cdeghrlkng 481 askilntlks ldirrklllt gtpiqndlne fftiidfinp gilgsfasfk rrfiipitra 541 rdtanrynee llekgeersk emieitkrfi lrrtnailek ylppktdiil fckpysqqil 601 afkdilqgar ldfgqltfss slglitllkk vcnspglvgs dpyykshikd tqsqdsysrs 661 lnsgklkvlm tllegirkgt kekvvvvsny tqtldiienl mnmagmshcr ldgsipakqr 721 dsivtsfnrn paifgfllsa ksggvglnlv gasrlilfdn dwnpsvdlqa msrihrdgqk 781 kpcfiyrlvt tgcidekilq rqlmknslsq kflgdsemrn kessnddlfn kedlkdlfsv 841 htdtksnthd licscdglge eieypetnqq qntvelrkrs tttwtsaldl qkkmneaatn 901 ddakksqyir qclvhykhid parqdelfde vitdsftelk dsitfafvkp geiclreq // LOCUS NP_009630 976 aa linear PLN 30-JUN-2025 DEFINITION Pff1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009630 VERSION NP_009630.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178422.2 REFERENCE 1 (residues 1 to 976) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 976) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 976) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 976) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 976) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 976) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 976) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07194. On Apr 26, 2011 this sequence version replaced NP_009630.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..976 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..976 /product="Pff1p" /calculated_mol_wt="110905" Region 50..354 /region_name="M28_Fxna_like" /note="M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; cd03875" /db_xref="CDD:349872" Region 366..>443 /region_name="DUF2189" /note="Predicted integral membrane protein (DUF2189); cl02291" /db_xref="CDD:470522" CDS 1..976 /gene="PFF1" /locus_tag="YBR074W" /gene_synonym="YBR075W" /coded_by="NM_001178422.2:1..2931" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347|PMID:23679341|PMID:26928762]" /note="Multi-spanning vacuolar membrane protease; glycosylated transmembrane protein bearing homology to M28 family of metalloproteases; has lumenal-facing protease domain; proposed role in vacuole physiology; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:852366" /db_xref="SGD:S000000278" ORIGIN 1 mklksvfrsv lkyrktnlsl lllitysiit llyifdhery klnlpkedeh pefndlleta 61 wgdlqiitas fhpytskend kvhdyllkrv leitgnssfa svsddkeser silfqqqdpf 121 nessrfsrvt yfessnilvk legknpeeeg lllsahfdsv ptgygatddg mgvvsllanl 181 kyhikhrpnr tlifnfnnne efgllgasty fdhswsnltk yvinlegtga ggkavlfrts 241 dtstariyqq svkenpfgns iyqqgfysry vrsetdykiy eengmrgwdv afykprnlyh 301 tikdsiqyts kaslwhmlht slqlsayvas nsldtadqtp acyfdfiglk ffvisaktlf 361 ywncifllvs pvvaiglyli srdrmtwksy swlswtrfpl slaagiivqk lfsndiirsn 421 pltfsrnyfw pisafftqvi ftsyvlincs nfffpcadmk slsiielfii lwtillftsk 481 llyssdyryt glyplsiffl lstiaailrl lalalgmrtr krlgrecrdh hsnysshsqi 541 dmerdgqenl eqpqdqltss qddqasiqdd nvsttsagps hnvdedhgmd sssqqhderv 601 pllkgsnsme eglstrensl kleytdyawi iqfllivpip sfilfnsvdv imdalnhtvq 661 egskatfdvl rfgmvgsili alpilpffyk vnyitislta llflisaskt llvhpftnsn 721 plkvrfsqni dlsqgnaasv hvlgregnfl kpmlqdlpsi kyssthinct svtngmelcm 781 ydgmqpnlls tngntnissm vkvhvlhnnr nsterspyep ivaelllevk enractltfe 841 srhqakspvr eitvyqkkns apqkanitkt iksasginel qlhkldfdqe tyhigvqwfp 901 klltdgnved dklgtkdels vsiscywgey dsesvvngta vrkipafdel inyaplsfsf 961 tneqkglviv kdaiil // LOCUS NP_009632 354 aa linear PLN 30-JUN-2025 DEFINITION Ecm8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009632 VERSION NP_009632.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178424.2 REFERENCE 1 (residues 1 to 354) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 354) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 354) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 354) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07195. On Apr 26, 2011 this sequence version replaced NP_009632.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..354 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..354 /product="Ecm8p" /calculated_mol_wt="41640" Region 164..282 /region_name="Rua1_C" /note="Transcription regulator Rua1, C-terminal; pfam14616" /db_xref="CDD:405322" Region 261..>342 /region_name="beta-trefoil_Ricin-like" /note="ricin B-type lectin domain, beta-trefoil fold; cl49609" /db_xref="CDD:483949" CDS 1..354 /gene="ECM8" /locus_tag="YBR076W" /coded_by="NM_001178424.2:1..1065" /note="Non-essential hypothetical protein" /db_xref="GeneID:852368" /db_xref="SGD:S000000280" ORIGIN 1 mdygyffpaq rieetngvdf widsnaeftq skrpdsstst lsrvltdttn vsnnsgslkr 61 ktiknkifpq rkifndsenf dfgkantdck hvfksiskql iflprcfqhh sirgwmkdry 121 sefgykikrn qncppsacvq alyntsrsnt eesnpnslds limykymrys ekkkelmcrf 181 cqgnnwilae nylkhlffah gilsefkpht lyhfeskllk iqgklnfkiq vlkepefskk 241 ilnsltvsii psplayytqt lnggfrrihv kcphcenwir lgwceydeii rdsfqdfesl 301 rnlnadyngm syiqtrnred iegiyenyft hyiqcdlatf rtkclyvqvi tksn // LOCUS NP_009633 162 aa linear PLN 30-JUN-2025 DEFINITION Slm4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009633 VERSION NP_009633.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178425.3 REFERENCE 1 (residues 1 to 162) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 162) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 162) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 162) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07196. On Jul 30, 2012 this sequence version replaced NP_009633.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..162 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..162 /product="Slm4p" /calculated_mol_wt="18223" Region 3..161 /region_name="SLM4" /note="Protein SLM4; pfam16818" /db_xref="CDD:407071" CDS 1..162 /gene="SLM4" /locus_tag="YBR077C" /gene_synonym="EGO3; GSE1; NIR1" /coded_by="NM_001178425.3:1..489" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:15989961|PMID:23708375|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0031902 late endosome membrane [PMID:16732272]" /experiment="EXISTENCE:direct assay:GO:0071986 Ragulator complex [PMID:16732272]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:15539461]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:15989961]" /experiment="EXISTENCE:physical interaction:GO:0071986 Ragulator complex [PMID:15989961]" /note="Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from endosome to plasma membrane; essential for integrity and function of EGO; targeted to vacuole via AP-3 pathway; gene exhibits synthetic genetic interaction with MSS4" /db_xref="GeneID:852369" /db_xref="SGD:S000000281" ORIGIN 1 mvmlhsknvk gflentlkpy dlhsvdfkts slqssmiita tnggilsyat snndvpknsi 61 neinsvnnlk mmsllikdkw sedendteeq hsnscypvei dsfktkiyty emedlhtcva 121 qipnsdllll fiaegsfpyg llvikieram reltdlfgyk lg // LOCUS NP_009634 429 aa linear PLN 30-JUN-2025 DEFINITION Ecm33p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009634 VERSION NP_009634.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178426.2 REFERENCE 1 (residues 1 to 429) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 429) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 429) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 429) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07197. On Apr 26, 2011 this sequence version replaced NP_009634.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..429 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..429 /product="Ecm33p" /calculated_mol_wt="43638" CDS 1..429 /gene="ECM33" /locus_tag="YBR078W" /coded_by="NM_001178426.2:1..1290" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12583915|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:15583168]" /note="GPI-anchored protein involved in efficient glucose uptake; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication" /db_xref="GeneID:852370" /db_xref="SGD:S000000282" ORIGIN 1 mqfknaltat ailsasalaa nsttsipssc sigtsatata qadldkisgc stivgnltit 61 gdlgsaalas iqeidgslti fnssslssfs adsikkitgd lnmqeliilt sasfgslqev 121 dsinmvtlpa istfstdlqn anniivsdtt lesvegfstl kkvnvfninn nrylnsfqss 181 lesvsdslqf ssngdnttla fdnlvwanni tlrdvnsisf gslqtvnasl gfinntlpsl 241 nltqlskvgq slsivsndel skaafsnltt vgggfiiann tqlkvidgfn kvqtvggaie 301 vtgnfstldl sslksvrgga nfdssssnfs cnalkklqsn gaiqgdsfvc kngatstsvk 361 lsststessk ssatssasss gdasnaqanv sasassssss skkskgaape lvpatsfmgv 421 vaavgvall // LOCUS NP_009635 964 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF3 core subunit a [Saccharomyces cerevisiae S288C]. ACCESSION NP_009635 VERSION NP_009635.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178427.1 REFERENCE 1 (residues 1 to 964) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 964) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 964) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 964) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07198. Method: conceptual translation. FEATURES Location/Qualifiers source 1..964 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..964 /product="translation initiation factor eIF3 core subunit a" /calculated_mol_wt="110214" Region 419..>495 /region_name="PINT" /note="motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; smart00088" /db_xref="CDD:214509" Region <595..>862 /region_name="DUF5401" /note="Family of unknown function (DUF5401); pfam17380" /db_xref="CDD:375164" CDS 1..964 /gene="RPG1" /locus_tag="YBR079C" /gene_synonym="TIF32" /coded_by="NM_001178427.1:1..2895" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11302750]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:19470581|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:15838098]" /experiment="EXISTENCE:mutant phenotype:GO:0002188 translation reinitiation [PMID:20679478]" /experiment="EXISTENCE:physical interaction:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9660829]" /note="eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; essential for loading mRNA onto ribosome at entry and exit channels of preinitiation complex; involved in translation reinitiation; eIF3 is also involved in programmed stop codon readthrough" /db_xref="GeneID:852371" /db_xref="SGD:S000000283" ORIGIN 1 mapppfrpen aikradelis vgekqaalqs lhdfitarri rwatpstvep vvfkfleigv 61 elkkgkllkd glhqykkliq gsteglvsvg avarkfidlv eskiaseqtr adelqkqeid 121 ddleggvtpe nllisvyesd qsvagfndea itswlrftwe syravldllr nnalleitys 181 gvvkktmhfc lkyqrknefk rlaemlrqhl daanyqqsks gnnlvdlsda dtlqryldqr 241 fqqvdvsvkl elwheayrsi edvfhlmkis krapkpstla nyyenlvkvf fvsgdpllht 301 tawkkfykly stnprateee fktysstifl saistqldei psigydphlr myrllnldak 361 ptrkemlqsi iedesiygkv deelkelydi ievnfdvdtv kqqlenllvk lssktyfsqy 421 iaplrdvimr rvfvaasqkf ttvsqselyk latlpapldl sawdieksll qaavedyvsi 481 tidhesakvt fakdpfdifa staskevsee entepevqee keetdealgp qetedgeeke 541 eesdpviirn syihnkllel snvlhdvdsf nnasymekvr iaretlikkn kddlekiski 601 vdervkrsqe qkqkhmehaa lhaeqdaevr qqrileekaa ieakleeeah rrliekkkre 661 feaikereit kmitevnakg hvyidpneak sldldtikqv iiaevsknks elesrmeyam 721 kkldhteral rkvelpllqk evdklqetdt anyeamkkki vdaakaeyea rmadrknlvm 781 vyddylkfke hvsgtkesel aairnqkkae leaakkarie evrkrryeea iarrkeeian 841 aerqkraqel aeatrkqrei eeaaakkstp ysfragnrep pstpstlpka tvspdkakld 901 miaqkqreme eaieqrlagr taggsspatp atpatpatpt pssgpkkmtm aeklrakrla 961 kggr // LOCUS NP_009636 758 aa linear PLN 30-JUN-2025 DEFINITION AAA family ATPase SEC18 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009636 VERSION NP_009636.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178428.3 REFERENCE 1 (residues 1 to 758) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 758) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 758) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 758) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07199. On Jul 30, 2012 this sequence version replaced NP_009636.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..758 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..758 /product="AAA family ATPase SEC18" /calculated_mol_wt="83925" Region 29..98 /region_name="CDC48_N" /note="Cell division protein 48 (CDC48) N-terminal domain; smart01073" /db_xref="CDD:215012" Region 134..204 /region_name="CDC48_2" /note="Cell division protein 48 (CDC48) domain 2; smart01072" /db_xref="CDD:215011" Region <232..>629 /region_name="CDC48" /note="AAA family ATPase, CDC48 subfamily; TIGR01243" /db_xref="CDD:273521" Region 240..416 /region_name="RecA-like_NSF-SEC18_r1-like" /note="first of two ATPase domains of NSF and SEC18, and similar ATPase domains; cd19504" /db_xref="CDD:410912" Site order(242,285..289,349) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:410912" Site order(254,257,261,267..271,316..317,320,324,373..374,377, 381..382,407) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:410912" CDS 1..758 /gene="SEC18" /locus_tag="YBR080C" /gene_synonym="ANU4" /coded_by="NM_001178428.3:1..2277" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:27364524]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:23613772]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9382859]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:10387016]" /experiment="EXISTENCE:direct assay:GO:0035494 SNARE complex disassembly [PMID:18650938|PMID:9425154]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:9685264|PMID:8670830]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0048280 vesicle fusion with Golgi apparatus [PMID:9382859]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:27364524]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:11694599]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11694599]" /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:2071670]" /experiment="EXISTENCE:mutant phenotype:GO:0048219 inter-Golgi cisterna vesicle-mediated transport [PMID:2071670|PMID:10637300]" /note="AAA ATPase and SNARE disassembly chaperone; required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian N-ethylmaleimide-sensitive factor (NSF)" /db_xref="GeneID:852372" /db_xref="SGD:S000000284" ORIGIN 1 mfkipgfgka aanhtppdmt nmdtrtrhlk vsncpnnsya lanvaavspn dfpnniyiii 61 dnlfvfttrh sndippgtig fngnqrtwgg wslnqdvqak afdlfkysgk qsylgsidid 121 isfrargkav stvfdqdela kqfvrcyesq ifsptqylim efqghffdlk irnvqaidlg 181 dieptsavat gietkgiltk qtqinffkgr dglvnlkssn slrprsnavi rpdfkfedlg 241 vggldkeftk ifrrafasri fppsvieklg ishvkgllly gppgtgktli arkigtmlna 301 kepkivngpe ilskyvgsse enirnlfkda eaeyrakgee sslhiiifde ldsvfkqrgs 361 rgdgtgvgdn vvnqllakmd gvdqlnnilv igmtnrkdli dsallrpgrf evqveihlpd 421 ekgrlqifdi qtkkmrennm msddvnlael aaltknfsga eieglvksas sfainktvni 481 gkgatklntk diaklkvtre dflnalndvt pafgiseedl ktcveggmml yservnsilk 541 ngaryvrqvr esdksrlvsl lihgpagsgk talaaeialk sgfpfirlis pnelsgmses 601 akiayidntf rdayksplni lvidsletlv dwvpigprfs nnilqmlkva lkrkppqdrr 661 llimtttsay svlqqmdils cfdneiavpn mtnldelnnv miesnfldda grvkvinels 721 rscpnfnvgi kktltnieta rhdedpvnel velmtqsa // LOCUS NP_009637 1332 aa linear PLN 30-JUN-2025 DEFINITION SAGA histone acetyltransferase complex subunit SPT7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009637 VERSION NP_009637.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178429.1 REFERENCE 1 (residues 1 to 1332) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1332) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1332) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1332) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07200. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1332 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1332 /product="SAGA histone acetyltransferase complex subunit SPT7" /calculated_mol_wt="152487" Region 282..680 /region_name="COG5076" /note="Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]" /db_xref="CDD:227408" Region 969..1085 /region_name="HFD_SPT7" /note="histone-fold domain found in protein SPT7 and similar proteins; cd22927" /db_xref="CDD:467052" Site order(969..971,973..983,985..986,988..989,991..992, 994..997,1001..1007,1009..1030,1036..1042,1044..1050,1052, 1056,1058,1063,1066,1069..1070,1073,1077,1080,1084) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467052" CDS 1..1332 /gene="SPT7" /locus_tag="YBR081C" /gene_synonym="GIT2" /coded_by="NM_001178429.1:1..3999" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9224714|PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12101232]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:7713415]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:9858534]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:9858534|PMID:12101232]" /note="Subunit of the SAGA transcriptional regulatory complex; involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex" /db_xref="GeneID:852373" /db_xref="SGD:S000000285" ORIGIN 1 mteripikny qrtnakallk lteklfnknf fdlyltsqql vvleyllsis seedklkawd 61 yflkgnialn veksfpltqe eehhgavspa vdtrsddvss qtikdnnntn tntsisnenh 121 veneiedkgd naianednfv nndesdnvee dlfkldledl kqqisgtrfi gnlslkiryv 181 lwqcaidyiy cdrnefgden dteytlldve ekeeeeigkn ekpqnkegis kfaededydd 241 edenydedst dvknvddppk nldsisssni eidderrlvl nisisketls klktnnveei 301 mgnwnkiyhs feydketmik rlkleesdkm iekgkkkrsr sdleaatdeq drentndepd 361 tnqklptpeg stfsdtgnkr pkqsnldltv nlgienlslk hllssiqqkk sqlgisdyel 421 khlimdvrkn rskwtsderi gqeelyeace kvvlelrnyt ehstpflnkv skreapnyhq 481 iikksmdlnt vlkklksfqy dskqefvddi mliwknclty nsdpshflrg haiamqkksl 541 qlirmipnit irnradleke iedmekdkdy eldeeeevag sgrkglnmga hmlakengkv 601 sekdssktvk deaptnddkl tsvipegeke kdktasstvt vhenvnknei kengkneeqd 661 mveesskted sskdadaakk dtedglqdkt aenkeagenn eeeedddded ededmvdsqs 721 yllekdddrd dleisvwktv takvraeicl krteyfkngk lnsdseaflk npqrmkrfdq 781 lfleykeqka lesyrqkieq nsimkngfgt vlkqedddql qfhndhslng neafekqpnd 841 ielddtrflq eydisnaipd ivyegvntkt ldkmedasvd rmlqnginkq srflankdlg 901 ltpkmnqnit liqqirhich kislirmlqs plsaqnsrsn pnaflnnhiy nytiiddsld 961 idpvsqlpth dyknnreliw kfmhkniskv amangfetah psainmltei agdylsnlik 1021 tlklhhetns lnrgtnveml qttllengin rpddlfsyve sefgkktkkl qdikqklesf 1081 lrallrptlq elsernfede sqsfftgdfa seltgedffg frelglekef gvlsssvplq 1141 llttqfqtvd getkvqakki qpeesdsivy kkitkgmlda gsfwntllpl lqkdyerska 1201 yiakqskssa ndktsmtste dnsfalleed qfvskktatk arlpptgkis ttykkkpias 1261 afilpeedle ndvkadpttt vnakvgaend gdsslflrtp qpldpldmdd afddtnmgsn 1321 ssfslslprl nq // LOCUS NP_009638 148 aa linear PLN 30-JUN-2025 DEFINITION E2 ubiquitin-conjugating protein UBC4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009638 VERSION NP_009638.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178430.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 148) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07201. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..148 /product="E2 ubiquitin-conjugating protein UBC4" /EC_number="2.3.2.23" /calculated_mol_wt="16325" Region 4..146 /region_name="UBCc_UBE2D" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzyme E2 D1-D3 and related proteins; cd23792" /db_xref="CDD:467412" CDS 1..148 /gene="UBC4" /locus_tag="YBR082C" /coded_by="NM_001178430.1:1..447" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:2154373]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20598539]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20598539]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:11788821]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:10848595]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21357418]" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:10848595]" /experiment="EXISTENCE:mutant phenotype:GO:0043130 ubiquitin binding [PMID:21357418]" /experiment="EXISTENCE:mutant phenotype:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:11788821]" /experiment="EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:20462952]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579]" /note="Ubiquitin-conjugating enzyme (E2); key E2 partner with Ubc1p for the anaphase-promoting complex (APC); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication" /db_xref="GeneID:852376" /db_xref="SGD:S000000286" ORIGIN 1 mssskriake lsdlerdppt scsagpvgdd lyhwqasimg padspyaggv fflsihfptd 61 ypfkppkisf ttkiyhpnin angnicldil kdqwspaltl skvllsicsl ltdanpddpl 121 vpeiahiykt drpkyeatar ewtkkyav // LOCUS NP_009639 486 aa linear PLN 30-JUN-2025 DEFINITION Tec1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009639 VERSION NP_009639.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178431.3 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 486) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07202. On Jul 30, 2012 this sequence version replaced NP_009639.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..486 /product="Tec1p" /calculated_mol_wt="55027" Region 127..192 /region_name="TEA" /note="TEA domain; smart00426" /db_xref="CDD:128703" CDS 1..486 /gene="TEC1" /locus_tag="YBR083W" /gene_synonym="ROC1" /coded_by="NM_001178431.3:1..1461" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:20118212]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9036858]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19218425]" /experiment="EXISTENCE:direct assay:GO:0033554 cellular response to stress [PMID:9036858]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9036858]" /experiment="EXISTENCE:direct assay:GO:1990527 Tec1p-Ste12p-Dig1p complex [PMID:16782869]" /experiment="EXISTENCE:direct assay:GO:2000222 positive regulation of pseudohyphal growth [PMID:9036858]" /experiment="EXISTENCE:genetic interaction:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:16782869]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:16782869]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12455687]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9036858|PMID:8730867|PMID:9055077]" /note="Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member" /db_xref="GeneID:852377" /db_xref="SGD:S000000287" ORIGIN 1 mslkeddfgk dnsrniesyt grifdvyiqk dsysqsaldd mfpeavvsta acvkneaedn 61 inlidthpqf elvntglgak sddlkspsak atftdkqrkn evpnisvsny fpgqssetss 121 tteswtigcd kwsekveeaf lealrlimkn gttkikirna nfgrnelisl yikhktnefr 181 tkkqisshiq vwkktiqnki kdsltlsske kellhliehg aeqttensnl fydifeeiid 241 slpsvsdsgs ltpknlyvsn nssglsvhsk lltpitasne kkienfiktn aasqaktpli 301 yakhiyenid gykcvpskrp leqlsptelh qgdrpnkasf snkkailesa kkieieqrki 361 inkyqrisri qehesnpefs snsnsgseye seeevvprsa tvtqlqsrpv pyyknngmpy 421 slskvrgrpm yprpaedayn anyiqglpqy qtsyfsqlll sspqhyehsp hqrnftpsnq 481 shgnfy // LOCUS NP_009640 975 aa linear PLN 30-JUN-2025 DEFINITION trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009640 VERSION NP_009640.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178432.1 REFERENCE 1 (residues 1 to 975) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 975) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 975) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 975) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 975) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 975) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 975) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07203. Method: conceptual translation. FEATURES Location/Qualifiers source 1..975 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..975 /product="trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase MIS1" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /EC_number="6.3.4.3" /calculated_mol_wt="106087" Region 37..323 /region_name="FolD" /note="5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]; COG0190" /db_xref="CDD:439960" Region 345..975 /region_name="FTHFS" /note="Formate--tetrahydrofolate ligase; pfam01268" /db_xref="CDD:460143" CDS 1..975 /gene="MIS1" /locus_tag="YBR084W" /coded_by="NM_001178432.1:1..2928" /experiment="EXISTENCE:direct assay:GO:0004329 formate-tetrahydrofolate ligase activity [PMID:3528153]" /experiment="EXISTENCE:direct assay:GO:0004477 methenyltetrahydrofolate cyclohydrolase activity [PMID:3528153]" /experiment="EXISTENCE:direct assay:GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity [PMID:3528153]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:3528153]" /experiment="EXISTENCE:direct assay:GO:0046656 folic acid biosynthetic process [PMID:3528153]" /experiment="EXISTENCE:mutant phenotype:GO:0006139 nucleobase-containing compound metabolic process [PMID:10781559]" /note="Mitochondrial C1-tetrahydrofolate synthase; involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase" /db_xref="GeneID:852378" /db_xref="SGD:S000000288" ORIGIN 1 mlsrlsllsn srafqqarwr iyrlkvsptv hasqyhilsg rklaqsirek andeiqaikl 61 khpnfkptlk iiqvgarpds styvrmklka skdsnvdcii eklpaeitev ellkkisdin 121 dddsihglli qlplprhlde ttitnavdfk kdvdgfhryn agelakkggk pyfipctpyg 181 cmklleeahv kldgknavvl grssivgnpi asllknanat vtvchshtrn iaevvsqadi 241 viaacgipqy vksdwikega vvidvginyv pdiskksgqk lvgdvdfdsv kektsyitpv 301 pggvgpmtva mlvsnvllaa krqfvesekl pvikplplhl espvpsdidi sraqspkhik 361 qvaeelgihs helelyghyk akispnifkr lesrengkyv lvagitptpl gegkstttmg 421 lvqalsahlg kpsianvrqp slgptlgvkg gaagggyaqv ipmdefnlhl tgdihaisaa 481 nnllaaaidt rmfheatqkn dstfykrlvp rkkgirkftp smqrrlkrld iekedpdalt 541 peevkrfarl ninpdtitir rvvdindrml rqitigeaat ekgftrttgf ditvaselma 601 ilalskslhe mkerigrmvi gadydnkpvt vedigctgal tallrdaikp nlmqtlegtp 661 vmvhagpfan isigassvia dlmalklvgs eknplndkni hepgyvvtea gfdfamgger 721 ffdikcrssg lvpdavvlva tvralkshgg apnvkpgqsl pkeyteenid fvakgvsnlv 781 kqieniktfg ipvvvainrf etdsqaeiev ikkaalnaga shavtsnhwm eggkgavela 841 havvdatkep knfnflydvn ssiedkltsi vqkmyggaki evspeaqkki dtykkqgfgn 901 lpiciaktqy slshdpslkg vprgftfpir dvrasigagy lyalaaeiqt ipglstyagy 961 mavevdddge ieglf // LOCUS NP_009641 189 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL19 RPL19A [Saccharomyces cerevisiae S288C]. ACCESSION NP_009641 VERSION NP_009641.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180057.1 REFERENCE 1 (residues 1 to 189) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 189) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 189) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 189) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07204. Method: conceptual translation. FEATURES Location/Qualifiers source 1..189 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..189 /product="60S ribosomal protein eL19 RPL19A" /calculated_mol_wt="21573" Region 4..166 /region_name="Ribosomal_L19e_E" /note="Ribosomal protein L19e, eukaryotic. L19e is found in the large ribosomal subunit of eukaryotes and archaea. L19e is distinct from the ribosomal subunit L19, which is found in prokaryotes. It consists of two small globular domains connected by an...; cd01417" /db_xref="CDD:238705" Site order(4,8..9,18..24,26,29,38,42,53,55..60,62,64,66..67, 69..70,72,74..79,81..89,92,95..97,100..101,103,110, 117..118,120..121,124..126,129,131,134..135) /site_type="other" /note="protein-rRNA interface [nucleotide binding]" /db_xref="CDD:238705" Site 28..47 /site_type="active" /note="putative translocon docking site [active]" /db_xref="CDD:238705" Site order(112..113,115..119,139..149) /site_type="active" /note="putative intersubunit bridge [active]" /db_xref="CDD:238705" CDS 1..189 /gene="RPL19A" /locus_tag="YBR084C-A" /coded_by="NM_001180057.1:1..570" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L19A; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal; homologous to mammalian ribosomal protein L19, no bacterial homolog; RPL19A has a paralog, RPL19B, that arose from the whole genome duplication" /db_xref="GeneID:852379" /db_xref="SGD:S000002156" ORIGIN 1 manlrtqkrl aasvvgvgkr kvwldpnets eiaqansrna irklvkngti vkkavtvhsk 61 srtrahaqsk regrhsgygk rkgtrearlp sqvvwirrlr vlrrllakyr dagkidkhly 121 hvlykeskgn afkhkralve hiiqakadaq rekalneeae arrlknraar drraqrvaek 181 rdallkeda // LOCUS NP_009642 307 aa linear PLN 30-JUN-2025 DEFINITION ADP/ATP carrier protein AAC3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009642 VERSION NP_009642.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178433.3 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 307) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07205. On Jul 30, 2012 this sequence version replaced NP_009642.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..307 /product="ADP/ATP carrier protein AAC3" /calculated_mol_wt="33182" Region 6..301 /region_name="PTZ00169" /note="ADP/ATP transporter on adenylate translocase; Provisional" /db_xref="CDD:240302" CDS 1..307 /gene="AAC3" /locus_tag="YBR085W" /gene_synonym="ANC3" /coded_by="NM_001178433.3:1..924" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0009061 anaerobic respiration [PMID:1915842|PMID:2165073]" /experiment="EXISTENCE:mutant phenotype:GO:0015886 heme transport [PMID:18728780]" /note="Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication" /db_xref="GeneID:852380" /db_xref="SGD:S000000289" ORIGIN 1 mssdakqqet nfainflmgg vsaaiaktaa spiervkili qnqdemikqg tldkkysgiv 61 dcfkrtakqe glisfwrgnt anviryfptq alnfafkdki klmfgfkkee gygkwfagnl 121 asggaagals llfvysldfa rtrlaadaks skkggarqfn gltdvykktl ksdgiaglyr 181 gfmpsvvgiv vyrglyfgmf dslkplvltg sldgsflasf llgwvvttga stcsypldtv 241 rrrmmmtsgq avkyngaidc lkkivasegv gslfkgcgan ilrsvagagv ismydqlqmi 301 lfgkkfk // LOCUS NP_061491 85 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR085C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_061491 VERSION NP_061491.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184443.1 REFERENCE 1 (residues 1 to 85) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 85) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 85) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 85) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07206. Method: conceptual translation. FEATURES Location/Qualifiers source 1..85 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..85 /product="uncharacterized protein" /calculated_mol_wt="9273" CDS 1..85 /locus_tag="YBR085C-A" /coded_by="NM_001184443.1:1..258" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852381" /db_xref="SGD:S000007522" ORIGIN 1 mssalykqst nfthstgsfl qsapvelttv sgyqeflkkq ekknyeiqtv lsedkshgyv 61 lkdgeviani igeakdylld lagqa // LOCUS NP_009643 946 aa linear PLN 30-JUN-2025 DEFINITION Ist2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009643 VERSION NP_009643.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178434.1 REFERENCE 1 (residues 1 to 946) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 946) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 946) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 946) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07207. On Jan 21, 2003 this sequence version replaced NP_009643.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..946 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..946 /product="Ist2p" /calculated_mol_wt="105723" Region 122..588 /region_name="Anoctamin" /note="Calcium-activated chloride channel; cl46385" /db_xref="CDD:480725" Region 779..>880 /region_name="PRK13335" /note="superantigen-like protein SSL3; Reviewed" /db_xref="CDD:139494" CDS 1..946 /gene="IST2" /locus_tag="YBR086C" /coded_by="NM_001178434.1:1..2841" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17234190|PMID:11030653]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:19453974]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:23237950]" /experiment="EXISTENCE:direct assay:GO:0033101 cellular bud membrane [PMID:11030653|PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]" /experiment="EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]" /experiment="EXISTENCE:mutant phenotype:GO:0072659 protein localization to plasma membrane [PMID:24416406]" /note="Cortical ER protein involved in ER-plasma membrane (PM) tethering; one of 6 proteins (Ist2, Scs2, Scs22, Tcb1, Tcb2, Tcb3) that connect ER to PM, regulate PM phosphatidylinositol-4-phosphate (PI4P) levels by controlling access of Sac1 phosphatase to PI4P; required to locate Osh6, Osh7 in ER/PM contact site to allow phosphatidylserine transport from ER to PM; localizes to mother in small-budded cells, to bud in medium-, large-budded cells; mRNA transported to bud tip by actomyosin-driven process" /db_xref="GeneID:852382" /db_xref="SGD:S000000290" ORIGIN 1 msqtitsldp ncvivfnkts sanekslnve fkrlnihsii epghdlqtsy afirihqdna 61 kplfsflqnl dfiesiipyh dtelsddlhk lisiskskil eapkqyelyn lsnltnnpkq 121 slyfaflqny ikwlipfsff glsirflsnf tyefnstysl failwtlsft afwlykyepf 181 wsdrlskyss fstieflqdk qkaqkkassv imlkkccfip vallfgaill sfqlycfale 241 ifikqiyngp misilsflpt ilictftpvl tviynkyfve pmtkwenhss vvnakkskea 301 knfviiflss yvpllitlfl ylpmghllta eirtkvfnaf silarlpthd sdfiidtkry 361 edqffyfivi nqliqfsmen fvpslvsiaq qkingpnpnf vkaeseigka qlsssdmkiw 421 skvksyqtdp wgatfdldan fkklllqfgy lvmfstiwpl apficlivnl ivyqvdlrka 481 vlyskpeyfp fpiydkpssv sntqkltvgl wnsvlvmfsi lgcvitatlt ymyqscnipg 541 vgahtsihtn kawylanpin hswinivlya vfiehvsvai fflfssilks shddvangiv 601 pkhvvnvqnp pkqevfekip spefnsnnek elvqrkgsan eklhqelgek qpassangye 661 ahaathannd psslssassp slsssssssk tgvvkavdnd tagsagkkpl atestekrns 721 lvkvptvgsy gvagatlpet iptsknyylr fdedgksird akssaessna tnnntlgtes 781 kllpdgdavd alsrkidqip kiavtggenn entqakddaa tktplikdan ikpvvnaavn 841 dnqskvsvat eqtkktevst kngpsrsist ketkdsarps nnnttttttt datqphhhhh 901 hhrhrdagvk nvtnnsktte ssssssaake kpkhkkgllh klkkkl // LOCUS NP_009644 354 aa linear PLN 30-JUN-2025 DEFINITION replication factor C subunit 5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009644 VERSION NP_009644.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178435.3 REFERENCE 1 (residues 1 to 354) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 354) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 354) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 354) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07208. On Jul 30, 2012 this sequence version replaced NP_009644.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..354 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..354 /product="replication factor C subunit 5" /calculated_mol_wt="39811" Region 3..>243 /region_name="PRK12402" /note="replication factor C small subunit 2; Reviewed" /db_xref="CDD:237090" CDS 1..354 /gene="RFC5" /locus_tag="YBR087W" /coded_by="NM_001178435.3:1..1065" /experiment="EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:12604797|PMID:8995429]" /experiment="EXISTENCE:direct assay:GO:0005663 DNA replication factor C complex [PMID:7651383]" /experiment="EXISTENCE:direct assay:GO:0006272 leading strand elongation [PMID:1346062]" /experiment="EXISTENCE:direct assay:GO:0031389 Rad17 RFC-like complex [PMID:12604797]" /experiment="EXISTENCE:mutant phenotype:GO:0005663 DNA replication factor C complex [PMID:8559655]" /experiment="EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:12665596]" /experiment="EXISTENCE:physical interaction:GO:0031389 Rad17 RFC-like complex [PMID:10660302]" /experiment="EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]" /experiment="EXISTENCE:physical interaction:GO:0031391 Elg1 RFC-like complex [PMID:12912927|PMID:12909721]" /note="Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon" /db_xref="GeneID:852383" /db_xref="SGD:S000000291" ORIGIN 1 mslwvdkyrp kslnalshne eltnflksls dqprdlphll lygpngtgkk trcmallesi 61 fgpgvyrlki dvrqfvtasn rklelnvvss pyhleitpsd mgnndriviq ellkevaqme 121 qvdfqdskdg lahrykcvii neansltkda qaalrrtmek ysknirlimv cdsmspiiap 181 iksrcllirc papsdseist ilsdvvtner iqletkdilk riaqasngnl rvsllmlesm 241 alnnelalks sspiikpdwi ivihkltrki vkersvnsli ecravlydll ahcipaniil 301 keltfslldv etlnttnkss iieyssvfde rlslgnkaif hlegfiakvm ccld // LOCUS NP_009645 258 aa linear PLN 30-JUN-2025 DEFINITION proliferating cell nuclear antigen [Saccharomyces cerevisiae S288C]. ACCESSION NP_009645 VERSION NP_009645.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178436.1 REFERENCE 1 (residues 1 to 258) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 258) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 258) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 258) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07209. Method: conceptual translation. FEATURES Location/Qualifiers source 1..258 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..258 /product="proliferating cell nuclear antigen" /calculated_mol_wt="28785" Region 1..258 /region_name="pcna" /note="proliferating cell nuclear antigen (pcna); TIGR00590" /db_xref="CDD:273158" Site order(13..14,20,77,80,146,149,210,217) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:238322" Site order(27,29,40,67,69,119..122,251..254) /site_type="other" /note="PCNA/WAF1-CIP1 protein binding site [polypeptide binding]" /db_xref="CDD:238322" Site order(40,47,249) /site_type="other" /note="PCNA/FEN-1 protein interaction site [polypeptide binding]" /db_xref="CDD:238322" Site order(77,80..82,111..117,143,146..147,149..150,173, 176..177,179..183) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:238322" Site order(208,251..253) /site_type="other" /note="PCNA/RFCL protein interaction site [polypeptide binding]" /db_xref="CDD:238322" CDS 1..258 /gene="POL30" /locus_tag="YBR088C" /coded_by="NM_001178436.1:1..777" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:12015307]" /experiment="EXISTENCE:direct assay:GO:0006272 leading strand elongation [PMID:1682321]" /experiment="EXISTENCE:direct assay:GO:0006273 lagging strand elongation [PMID:7673186]" /experiment="EXISTENCE:direct assay:GO:0030337 DNA polymerase processivity factor activity [PMID:18635534|PMID:2902631]" /experiment="EXISTENCE:direct assay:GO:0051054 positive regulation of DNA metabolic process [PMID:12192046|PMID:30778235]" /experiment="EXISTENCE:genetic interaction:GO:0000278 mitotic cell cycle [PMID:7516465]" /experiment="EXISTENCE:genetic interaction:GO:0000710 meiotic mismatch repair [PMID:18245822]" /experiment="EXISTENCE:genetic interaction:GO:0006298 mismatch repair [PMID:8910404|PMID:9504910]" /experiment="EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:8790390]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:16934511]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:10545450]" /experiment="EXISTENCE:genetic interaction:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:16934511]" /experiment="EXISTENCE:genetic interaction:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:16079237]" /experiment="EXISTENCE:genetic interaction:GO:0070987 error-free translesion synthesis [PMID:19264809]" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:18245822]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:9806417]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:8858149]" /experiment="EXISTENCE:mutant phenotype:GO:0006301 postreplication repair [PMID:8790390]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16157874]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16157874]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:16079237]" /experiment="EXISTENCE:physical interaction:GO:0006273 lagging strand elongation [PMID:7673186]" /experiment="EXISTENCE:physical interaction:GO:0006298 mismatch repair [PMID:8858149]" /experiment="EXISTENCE:physical interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:16934511]" /experiment="EXISTENCE:physical interaction:GO:0043626 PCNA complex [PMID:8001157]" /note="Proliferating cell nuclear antigen (PCNA); functions as the sliding replication clamp for DNA polymerase delta; may function as docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair; PCNA ubiquitination at K164 plays crucial role during Okazaki fragment processing; Leu164 is essential for stable complex formation with replicative DNA polymerase delta" /db_xref="GeneID:852385" /db_xref="SGD:S000000292" ORIGIN 1 mleakfeeas lfkriidgfk dcvqlvnfqc kedgiiaqav ddsrvllvsl eigveafqey 61 rcdhpvtlgm dltslskilr cgnntdtltl iadntpdsii llfedtkkdr iaeyslklmd 121 idadflkiee lqydstlslp ssefskivrd lsqlsdsini mitketikfv adgdigsgsv 181 iikpfvdmeh petsiklemd qpvdltfgak ylldiikgss lsdrvgirls seapalfqfd 241 lksgflqffl apkfndee // LOCUS NP_009647 99 aa linear PLN 30-JUN-2025 DEFINITION high-mobility group nucleosome-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009647 VERSION NP_009647.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180058.2 REFERENCE 1 (residues 1 to 99) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 99) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 99) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 99) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07210. On Jul 1, 2011 this sequence version replaced NP_009647.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..99 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..99 /product="high-mobility group nucleosome-binding protein" /calculated_mol_wt="11345" Region 14..94 /region_name="HMG-box_NHP6-like" /note="high mobility group (HMG)-box found in Saccharomyces cerevisiae non-histone chromosomal proteins NHP6A, NHP6B and similar proteins; cd01390" /db_xref="CDD:438792" Site order(15..22,28..35,38..39,42,46,53..54,57..59,62..63, 65..66,73,77,80,84,87,91,94) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:438792" CDS 1..99 /gene="NHP6B" /locus_tag="YBR089C-A" /gene_synonym="YBR090C-A" /coded_by="NM_001180058.2:1..300" /experiment="EXISTENCE:direct assay:GO:0001195 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase III [PMID:16407207]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:3169249]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:7721780]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:17178828]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:14739928]" /experiment="EXISTENCE:genetic interaction:GO:0006366 transcription by RNA polymerase II [PMID:8946917]" /experiment="EXISTENCE:genetic interaction:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11287614]" /note="High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication" /db_xref="GeneID:852386" /db_xref="SGD:S000002157" ORIGIN 1 maatkeakqp kepkkrttrr kkdpnapkrg lsaymffane nrdivrsenp dvtfgqvgri 61 lgerwkalta eekqpyeska qadkkryese kelynatra // LOCUS NP_009648 122 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR090C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009648 VERSION NP_009648.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178438.4 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 122) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07211. On Jul 30, 2012 this sequence version replaced NP_009648.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..122 /product="uncharacterized protein" /calculated_mol_wt="14190" CDS 1..122 /locus_tag="YBR090C" /coded_by="NM_001178438.4:1..369" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus" /db_xref="GeneID:852387" /db_xref="SGD:S000000294" ORIGIN 1 mvpapgsraf pspvflggvf fvfffrwrgn ykvqqvrlrq yweftlweta pntkqkndff 61 aktltyikla lwpqlkkqsn qrnqrrgppg erriltplrg acqlicsllm ktetlsvpri 121 lt // LOCUS NP_009649 109 aa linear PLN 30-JUN-2025 DEFINITION Tim12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009649 VERSION NP_009649.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178439.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 109) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07212. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..109 /product="Tim12p" /calculated_mol_wt="12153" Region 12..78 /region_name="zf-Tim10_DDP" /note="Tim10/DDP family zinc finger; pfam02953" /db_xref="CDD:460764" CDS 1..109 /gene="TIM12" /locus_tag="YBR091C" /gene_synonym="MRS5" /coded_by="NM_001178439.1:1..330" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:18387953]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9430585|PMID:9495346]" /experiment="EXISTENCE:direct assay:GO:0042721 TIM22 mitochondrial import inner membrane insertion complex [PMID:9495346]" /experiment="EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9495346]" /experiment="EXISTENCE:mutant phenotype:GO:0005543 phospholipid binding [PMID:18387953]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:9495346|PMID:9430585]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9495346|PMID:9430585]" /note="Essential protein of the inner mitochondrial membrane; peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins" /db_xref="GeneID:852388" /db_xref="SGD:S000000295" ORIGIN 1 msfflnslrg nqevsqekld vagvqfdamc stfnnilstc lekciphegf gepdltkgeq 61 ccidrcvakm hysnrliggf vqtrgfgpen qlrhysrfva keiaddskk // LOCUS NP_009650 467 aa linear PLN 30-JUN-2025 DEFINITION acid phosphatase PHO3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009650 VERSION NP_009650.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178440.1 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 467) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07213. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..467 /product="acid phosphatase PHO3" /EC_number="3.1.3.2" /calculated_mol_wt="52646" Region 65..399 /region_name="His_Phos_2" /note="Histidine phosphatase superfamily (branch 2); pfam00328" /db_xref="CDD:395259" Site order(74..75,78,175,337..338) /site_type="active" /note="catalytic core [active]" /db_xref="CDD:132717" CDS 1..467 /gene="PHO3" /locus_tag="YBR092C" /coded_by="NM_001178440.1:1..1404" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006796 phosphate-containing compound metabolic process [PMID:2407294]" /experiment="EXISTENCE:direct assay:GO:0042723 thiamine-containing compound metabolic process [PMID:2407294]" /experiment="EXISTENCE:mutant phenotype:GO:0003993 acid phosphatase activity [PMID:2676709]" /experiment="EXISTENCE:mutant phenotype:GO:0030287 cell wall-bounded periplasmic space [PMID:2676709]" /note="Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin" /db_xref="GeneID:852389" /db_xref="SGD:S000000296" ORIGIN 1 mfksvvysvl aaalvnagti plgeladvak igtqedifpf lggagpyfsf pgdygisrdl 61 pegcemkqlq mlarhgeryp tyskgatimk twyklsnytr qfngslsfln ddyeffirdd 121 ddlemettfa nsdnvlnpyt gemdakrhar eflaqygymf enqtsfpifa asservhdta 181 qyfidglgdq fnislqtvse amsagantls agnacpgwde danddildky dttylddiak 241 rlnkenkgln ltskdantlf awcayelnar gysdvcdift edelvrysyg qdlvsfyqdg 301 pgydmirsvg anlfnatlkl lkqsetqdlk vwlsfthdtd ilnylttagi iddknnltae 361 yvpfmgntfh kswyvpqgar vytekfqcsn dtyvryvind avvpietcst gpgfsceind 421 fydyaekrva gtdflkvcnv ssvsnvtelt fywdwntthy ndtllkq // LOCUS NP_009651 467 aa linear PLN 30-JUN-2025 DEFINITION acid phosphatase PHO5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009651 VERSION NP_009651.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178441.3 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 467) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07214. On Jul 30, 2012 this sequence version replaced NP_009651.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..467 /product="acid phosphatase PHO5" /EC_number="3.1.3.2" /calculated_mol_wt="52728" Region 65..399 /region_name="His_Phos_2" /note="Histidine phosphatase superfamily (branch 2); pfam00328" /db_xref="CDD:395259" Site order(74..75,78,175,337..338) /site_type="active" /note="catalytic core [active]" /db_xref="CDD:132717" CDS 1..467 /gene="PHO5" /locus_tag="YBR093C" /coded_by="NM_001178441.3:1..1404" /experiment="EXISTENCE:direct assay:GO:0003993 acid phosphatase activity [PMID:8817921]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:3537693]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:16278456]" /experiment="EXISTENCE:genetic interaction:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0006796 phosphate-containing compound metabolic process [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0016036 cellular response to phosphate starvation [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]" /note="Repressible acid phosphatase; 1 of 3 repressible acid phosphatases that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2" /db_xref="GeneID:852390" /db_xref="SGD:S000000297" ORIGIN 1 mfksvvysil aaslanagti plgkladvdk igtqkdifpf lggagpyysf pgdygisrdl 61 pegcemkqlq mvgrhgeryp tvslaktiks twyklsnytr qfngslsfln ddyeffirdd 121 ddlemettfa nsddvlnpyt gemnakrhar dflaqygymv enqtsfavft snskrchdta 181 qyfidglgdq fnitlqtvse aesagantls acnscpawdy danddivney dttylddiak 241 rlnkenkgln ltstdastlf swcafevnak gysdvcdift kdelvhysyy qdlhtyyheg 301 pgydiiksvg snlfnasvkl lkqseiqdqk vwlsfthdtd ilnflttagi iddknnltae 361 yvpfmgntfh rswyvpqgar vytekfqcsn dtyvryvind avvpietcst gpgfsceind 421 fydyaekrva gtdflkvcnv ssvsnstelt fywdwntthy nasllrq // LOCUS NP_009652 753 aa linear PLN 30-JUN-2025 DEFINITION putative tubulin tyrosine ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009652 VERSION NP_009652.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178442.2 REFERENCE 1 (residues 1 to 753) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 753) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 753) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 753) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07215. On Apr 26, 2011 this sequence version replaced NP_009652.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..753 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..753 /product="putative tubulin tyrosine ligase" /EC_number="6.3.2.25" /calculated_mol_wt="86223" Region 1..311 /region_name="surE" /note="5'/3'-nucleotidase SurE; TIGR00087" /db_xref="CDD:272899" Region 389..732 /region_name="TTL" /note="Tubulin-tyrosine ligase family; pfam03133" /db_xref="CDD:397308" CDS 1..753 /gene="PBY1" /locus_tag="YBR094W" /coded_by="NM_001178442.2:1..2262" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:17307817]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /note="Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null mutant is actually wild-type for PBY1 and deleted for mms4" /db_xref="GeneID:852391" /db_xref="SGD:S000000298" ORIGIN 1 mrvlitnddg plsdqfspyi rpfiqhikrn ypewkitvcv phvqkswvgk ahlagknlta 61 qfiyskvdae dntfwgpfiq pqirsenskl pyvlnaeipk dtiewilidg tpascanigl 121 hllsnepfdl vlsgpnvgrn tsaayitssg tvggamesvi tgntkaiais wayfnglknv 181 spllmekask rsldvikhlv knwdpktdly siniplvesl sddtkvyyap iwenrwipif 241 ngphinlens faeiedgnes ssisfnwapk fgahkdsihy mdeykdrtvl tdaeviesem 301 isvtpmkatf kgvnhllgel klteeennls ktnnlivvsi dpmeyiykpl thalkkylpq 361 veivsnlpef dnggcekemk vfhygdyeql dmdklmelpn nyftnsyiyr kalirkhfls 421 htiqtytakn pesilkkayl esftidldya eflddalden welrqelene sqdkwwivkp 481 smsdkgqgir vfktiedlqa ifdsfddeds eaeesgnddd addvngefmd nnkvnisqlr 541 hfiiqeyltn plllasmdnr kfhircyvvc rgdlqvfvyd rmlalfaakp fvpldpyays 601 vtdlkdlech ltntclqskk kdkdssvlef dsieeipner ksnikeqihs itndvflaav 661 nvnrlnfqpl pnafetygvd flidsnyevk lleinafpdf kqtgkdlknl idelfddtvk 721 ycvtpifnen rnktddetdp nfvkvidyts ngw // LOCUS NP_009653 430 aa linear PLN 30-JUN-2025 DEFINITION Rxt2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009653 VERSION NP_009653.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178443.1 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 430) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07216. On Oct 2, 2003 this sequence version replaced NP_009653.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..430 /product="Rxt2p" /calculated_mol_wt="48498" Region 62..221 /region_name="RXT2_N" /note="RXT2-like, N-terminal; pfam08595" /db_xref="CDD:430097" CDS 1..430 /gene="RXT2" /locus_tag="YBR095C" /gene_synonym="RAF60" /coded_by="NM_001178443.1:1..1293" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:19040720|PMID:16314178|PMID:16286008|PMID:16286007]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16275642]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:10628851]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:10628851]" /experiment="EXISTENCE:mutant phenotype:GO:0004407 histone deacetylase activity [PMID:16275642]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:18202364]" /note="Component of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852392" /db_xref="SGD:S000000299" ORIGIN 1 mtirssmknn aelesksvla nesniistft rriikeksgn yqvlkrsldg kliypeatgi 61 ssnrgnkllq rsevvtrrdl nnskpmieqt vfyngsehrl lqtnivtdsr rkrikftpdi 121 nvepvlvgde ndidgseked enitdeyyge eddddlsklv nvkeiltpil slgdiinhkt 181 isrtfsspil knlalqiilm iekeqmsvvr ysqflevflg dhpepiyesn lnlpsynhnl 241 tlpedrgasd eddinnknni nevnsnslst eaghinngme efgeedpffa lprleqsnal 301 lsllpsssgs asistltaae qqqlneeies arqlsqialq rnkefirnlq kirksvikan 361 rirgrilnws reylgisddd itipvalrvv krglisattn kttnfeeeie ntmedgvvdd 421 nepdeeanra // LOCUS NP_009654 230 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR096W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009654 VERSION NP_009654.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178444.3 REFERENCE 1 (residues 1 to 230) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 230) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 230) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 230) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07217. On Jul 30, 2012 this sequence version replaced NP_009654.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..230 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..230 /product="uncharacterized protein" /calculated_mol_wt="26961" Region 73..175 /region_name="4HBT" /note="4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; cd00586" /db_xref="CDD:238329" Site order(92,116,118,145..148) /site_type="active" /db_xref="CDD:238329" CDS 1..230 /locus_tag="YBR096W" /coded_by="NM_001178444.3:1..693" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the ER" /db_xref="GeneID:852393" /db_xref="SGD:S000000300" ORIGIN 1 mgvctifrwl faayllssyk slpgayfvrf yyyviqnlfl pmftgfeten ikklekneyg 61 cfsytsldty aspfecdfyf hksnstyfae ldisrgnlmc kifqklmlns khypyipvan 121 vftnflkeik pfqkysvssr iicwdekwiy vmsrftikkg tvlcslsltk yvlkdgrkti 181 kpkdaleycg lynekvakis ednlkllter cgfhetvple nlsqeycsei // LOCUS NP_009655 1454 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-binding serine/threonine protein kinase VPS15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009655 VERSION NP_009655.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178445.2 REFERENCE 1 (residues 1 to 1454) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1454) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1454) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1454) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07218. On Apr 26, 2011 this sequence version replaced NP_009655.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1454 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1454 /product="ubiquitin-binding serine/threonine protein kinase VPS15" /EC_number="2.7.11.1" /calculated_mol_wt="166242" Region 26..304 /region_name="STKc_Vps15" /note="Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15; cd13980" /db_xref="CDD:270882" Site order(33..37,41,52,54,86,102..105,108,110,147,149,151..152, 154,165,168,192..195) /site_type="active" /db_xref="CDD:270882" Site order(33..37,41,52,54,86,102..105,108,147,149,151..152,154, 165) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270882" Site order(37,108,110,147,149,151,168,192..195) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270882" Site order(164..169,171..187,192..195) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270882" Region 511..538 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(530..531,534,537..538,557..558,561,564..565,568, 598..599,602,605..606,609,637..638,641,644..645,676..677, 680,683..684) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 542..568 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 580..610 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 619..645 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 656..685 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 695..729 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1080..>1312 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 1083..1127 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1132..1183 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1188..1227 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1235..1270 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1277..1317 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1343..1414 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1427..1453 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..1454 /gene="VPS15" /locus_tag="YBR097W" /gene_synonym="GRD8; VAC4; VPL19; VPS40; VPT15" /coded_by="NM_001178445.2:1..4365" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:7989323]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I [PMID:11157979]" /experiment="EXISTENCE:direct assay:GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II [PMID:11157979]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:23335340]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:21121900]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:7721937]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11157979|PMID:32788210]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:23335340]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:11157979]" /experiment="EXISTENCE:mutant phenotype:GO:0051365 cellular response to potassium ion starvation [PMID:32788210]" /note="Serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p; myristoylated; a fraction is localized, with Vps34p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery" /db_xref="GeneID:852394" /db_xref="SGD:S000000301" ORIGIN 1 mgaqlslvvq aspsiaifsy idvleevhyv sqlnssrflk tckaldpnge ivikvfikpk 61 dqyslrpflq riraqsfklg qlphvlnysk lietnragym irqhlknnly drlslrpylq 121 dielkfiafq llnalkdihn lnivhgdikt enilvtswnw ciltdfaafi kpvylpednp 181 geflfyfdts krrtcylape rfnsklyqdg ksnngrltke mdifslgcvi aeifaegrpi 241 fnlsqlfkyk snsydvnref lmeemnstdl rnlvldmiql dpskrlscde llnkyrgiff 301 pdyfytfiyd yfrnlvtmtt stpisdntct nstlednvkl ldettekiyr dfsqichcld 361 fplikdggei gsdppilesy kieieisrfl ntnlyfpqny hlvlqqftkv sekiksvkee 421 callfisyls hsirsivsta tklknlella vfaqfvsden kidrvvpyfv ccfedsdqdv 481 qalslltliq vltsvrklnq lnenifvdyl lprlkrllis nrqntnylri vfanclsdla 541 iiinrfqeft faqhcndnsm dnnteimess tkysakliqs vedltvsflt dndtyvkmal 601 lqnilplckf fgrertndii lshlitylnd kdpalrvsli qtisgisill gtvtleqyil 661 plliqtitds eelvvisvlq slkslfktgl irkkyyidis kttsplllhp nnwirqftlm 721 iiieiinkls kaevycilyp iirpffefdv efnfksmisc ckqpvsrsvy nllcswsvra 781 skslfwkkii tnhvdsfgnn riefitknys sknygfnkrd tksssslkgi ktsstvyshd 841 nkeipltaed rnwidkfhii gltekdiwki valrgyvirt arvmaanpdf pynnsnyrpl 901 vqnsppnlnl tnimprniff dvefaeests egqdsnlenq qiykydesek dsnklnings 961 kqlstvmdin gslifknksi atttsnlknv fvqleptsyh mhspnhglkd nanvkperkv 1021 vvsnsyegdv esiekflstf kilpplrdyk efgpiqeivr spnmgnlrgk liatlmenep 1081 nsitssavsp getpylitgs dqgvikiwnl keiivgevys ssltydcsst vtqitmipnf 1141 dafavsskdg qiivlkvnhy qqesevkfln cecirkinlk nfgkneyavr mrafvneeks 1201 llvaltnlsr viifdirtle rlqiienspr hgavssicid eeccvlilgt trgiidiwdi 1261 rfnvlirsws fgdhapithv evcqfygkns vivvggsskt fltiwnfvkg hcqyafinsd 1321 eqpsmehflp iekgleelnf cgirslnals tisvsndkil ltdeatssiv mfslnelsss 1381 kavispsrfs dvfiptqvta nltmllrkmk rtsthsvdds lyhhdiinsi stcevdetpl 1441 lvacdnsgli gifq // LOCUS NP_009656 691 aa linear PLN 30-JUN-2025 DEFINITION Mms4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009656 VERSION NP_009656.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178446.1 REFERENCE 1 (residues 1 to 691) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 691) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 691) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 691) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07219. On Jan 21, 2003 this sequence version replaced NP_009656.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..691 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..691 /product="Mms4p" /calculated_mol_wt="78633" Region 397..599 /region_name="XPF_nuclease_EME-like" /note="XPF-like nuclease domain of the family of Essential Meiotic Endonucleases (EMEs) and similar proteins; cd20080" /db_xref="CDD:410856" Site order(499,555,559..560,563..564,566..567,571..572,574, 584..585,588..589,591..592,599) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:410856" Site order(591,599) /site_type="other" /note="nucleic acid substrate binding site [nucleotide binding]" /db_xref="CDD:410856" CDS 1..691 /gene="MMS4" /locus_tag="YBR098W" /gene_synonym="SLX2; YBR100W" /coded_by="NM_001178446.1:1..2076" /experiment="EXISTENCE:direct assay:GO:0004520 DNA endonuclease activity [PMID:11641278]" /experiment="EXISTENCE:direct assay:GO:0008821 crossover junction DNA endonuclease activity [PMID:17363897]" /experiment="EXISTENCE:direct assay:GO:0048476 Holliday junction resolvase complex [PMID:17363897]" /experiment="EXISTENCE:genetic interaction:GO:0000712 resolution of meiotic recombination intermediates [PMID:18691964]" /experiment="EXISTENCE:genetic interaction:GO:0006265 DNA topological change [PMID:11139495]" /experiment="EXISTENCE:genetic interaction:GO:0007131 reciprocal meiotic recombination [PMID:11641278]" /experiment="EXISTENCE:genetic interaction:GO:0010520 regulation of reciprocal meiotic recombination [PMID:18691965]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:9604884]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:11139495]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:18615017]" /note="Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates the function of Mms4p-Mus81p" /db_xref="GeneID:852395" /db_xref="SGD:S000000302" ORIGIN 1 msqivdfved kdsrndasiq iidgpsnvei ialsesmdqd eckrahvssa emipsspqrk 61 svsndvenvd lnksielsap ffqdisiskl ddfsttvnsi idsslrnenn akgnakklld 121 dlisdewsad lessgkkhnk sqynlrdiae kwgvqslknp epiavdceyk tqgigktnsd 181 isdspksqig aadilfdfpl spvkhenpte ekhnsianen sspdnslkpa gkqnhgedgt 241 smakrvynkg edeqehlpkg kkrtialsrt linstklpdt velnlskfld ssdsittdvl 301 stpakgsniv rtgsqpifsn ancfqeakrs ktltaedpkc tkntarevsq lenyiaygqy 361 ytredsknki rhllkenkna fkrvnqiyrd nikarsqmii efspsllqlf kkgdsdlqqq 421 lapavvqssy ndsmpllrfl rkcdsiydfs ndfyypcdpk iveenvlily ydaqeffeqy 481 tsqkkelyrk irffskngkh vililsdink lkraifqlen ekykarveqr lsgteealrp 541 rskkssqvgk lgikkfdleq rlrfidrewh vkihtvnshm efinslpnlv sligkqrmdp 601 airymkyahl nvksaqdste tlkktfhqig rmpemkannv vslypsfqsl lediekgrlq 661 sdnegkylmt eavekrlykl ftctdpndti e // LOCUS NP_009659 290 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 nucleotide exchange factor FES1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009659 VERSION NP_009659.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178449.3 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 290) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07220. On Jul 30, 2012 this sequence version replaced NP_009659.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..290 /product="Hsp70 nucleotide exchange factor FES1" /calculated_mol_wt="32473" Region 1..82 /region_name="Fes1" /note="Nucleotide exchange factor Fes1; pfam08609" /db_xref="CDD:462534" Region 125..224 /region_name="SPK" /note="Domain of unknown function (DUF545); cl11619" /db_xref="CDD:472233" CDS 1..290 /gene="FES1" /locus_tag="YBR101C" /coded_by="NM_001178449.3:1..873" /experiment="EXISTENCE:direct assay:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:12052876]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12052876]" /experiment="EXISTENCE:direct assay:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:23530227]" /experiment="EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:23530227]" /note="Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for degradation; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852397" /db_xref="SGD:S000000305" ORIGIN 1 mekllqwsia nsqgdkeama ragqpdpkll qqlfggggpd dptlmkesma vimnpevdle 61 tklvafdnfe mlienldnan nienlklwep lldvlvqtkd eelraaalsi igtavqnnld 121 sqnnfmkydn glrslieias dktkpldvrt kafyalsnli rnhkdisekf fklngldcia 181 pvlsdntakp klkmraiall taylssvkid eniisvlrkd gviestiecl sdesnlniid 241 rvlsflshli ssgikfneqe lhklnegykh ieplkdrlne ddylavkyvl // LOCUS NP_009660 753 aa linear PLN 30-JUN-2025 DEFINITION exocyst subunit EXO84 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009660 VERSION NP_009660.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178450.1 REFERENCE 1 (residues 1 to 753) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 753) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 753) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 753) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07221. Method: conceptual translation. FEATURES Location/Qualifiers source 1..753 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..753 /product="exocyst subunit EXO84" /calculated_mol_wt="85407" Region <19..>181 /region_name="Herpes_BLLF1" /note="Herpes virus major outer envelope glycoprotein (BLLF1); pfam05109" /db_xref="CDD:282904" Region 177..259 /region_name="Vps51" /note="Vps51/Vps67; pfam08700" /db_xref="CDD:462568" Region 340..444 /region_name="PH-like" /note="Pleckstrin homology-like domain; cl17171" /db_xref="CDD:473070" Region 534..738 /region_name="Exo84_C" /note="Exocyst component 84 C-terminal; pfam16528" /db_xref="CDD:465161" CDS 1..753 /gene="EXO84" /locus_tag="YBR102C" /gene_synonym="USA3" /coded_by="NM_001178450.1:1..2262" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10438536]" /experiment="EXISTENCE:direct assay:GO:0000145 exocyst [PMID:10438536]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10438536]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10438536]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:10438536]" /experiment="EXISTENCE:mutant phenotype:GO:0000245 spliceosomal complex assembly [PMID:11425851]" /experiment="EXISTENCE:mutant phenotype:GO:0001927 exocyst assembly [PMID:15788396]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:10438536|PMID:15788396]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:15788396|PMID:10438536]" /experiment="EXISTENCE:mutant phenotype:GO:0051601 exocyst localization [PMID:15788396]" /experiment="EXISTENCE:physical interaction:GO:0000245 spliceosomal complex assembly [PMID:11425851]" /note="Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting of the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate" /db_xref="GeneID:852398" /db_xref="SGD:S000000306" ORIGIN 1 mvefslkkar nnwkhvkksa sspakqktpp spakpkqktk knpysdlkdp atsytlptin 61 arersrvats mqrrlsihnt nyapptldys mplpdmpnmi vpndnvdssh nnssfttene 121 svsskgpsns lnlstadlsl ndssynkvpa rsamrntvnp sgsndpfnns tslrkmlanp 181 hfnakdfvhd klgnasaiti dkftsnltdl siqvqeevkl ninksyneim tvnndlnvam 241 lelkrvrani ndlnevldqc tkiaekrlql qdqidqerqg nfnnveshsn spallpplka 301 gqngnlmrrd rssvlilekf wdteldqlfk nvegaqkfin stkgrhilmn sanwmelntt 361 tgkplqmvqi filndlvlia dksrdkqndf ivsqcyplkd vtvtqeefst krllfkfsns 421 nsslyecrda decsrlldvi rkakddlcdi fhveeenskr iresfrylqs tqqtpgrenn 481 rspnknkrrs mggsitpgrn vtgamdqyll qnltlsmhsr prsrdmssta qrlkfldegv 541 eeidielarl rfesavetll diesqledls erisdeelml lnlislkieq rreaisskls 601 qsilssneiv hlksgtenmi klglpeqald lflqnrsnfi qdlilqigsv dnptnyltql 661 avirfqtikk tvedfqdifk elgakissil vdwcsdevdn hfklidkqll ndemlspgsi 721 kssrkqidgl kavgldfvyk ldefikknsd kir // LOCUS NP_009661 535 aa linear PLN 30-JUN-2025 DEFINITION Sif2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009661 VERSION NP_009661.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178451.1 REFERENCE 1 (residues 1 to 535) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 535) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 535) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 535) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07222. Method: conceptual translation. FEATURES Location/Qualifiers source 1..535 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..535 /product="Sif2p" /calculated_mol_wt="59030" Region 7..31 /region_name="LisH" /note="pfam08513" /db_xref="CDD:462501" Region <220..472 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 224..259 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 264..300 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 322..356 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 362..398 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 445..482 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..535 /gene="SIF2" /locus_tag="YBR103W" /gene_synonym="EMB1" /coded_by="NM_001178451.1:1..1608" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9651685]" /experiment="EXISTENCE:direct assay:GO:0034967 Set3 complex [PMID:11711434]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:19379692]" /experiment="EXISTENCE:mutant phenotype:GO:0032874 positive regulation of stress-activated MAPK cascade [PMID:18487345]" /experiment="EXISTENCE:physical interaction:GO:0045835 negative regulation of meiotic nuclear division [PMID:11711434]" /note="WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus" /db_xref="GeneID:852399" /db_xref="SGD:S000000307" ORIGIN 1 msitseelny liwrycqemg hevsalalqd etrvlefdek ykehiplgtl vnlvqrgily 61 teselmvdsk gdisalnehh lsedfnlvqa lqidkekfpe issegrftle tnsesnkage 121 dgastveret qeddtnsids sddldgfvki lkeivkldni vsstwnplde silaygekns 181 varlarivet dqegkkywkl tiiaelrhpf alsassgktt nqvtclawsh dgnsivtgve 241 ngelrlwnkt gallnvlnfh rapivsvkwn kdgthiismd venvtilwnv isgtvmqhfe 301 lketggssin aenhsgdgsl gvdvewvddd kfvipgpkga ifvyqitekt ptgklighhg 361 pisvlefndt nklllsasdd gtlriwhggn gnsqncfygh sqsivsaswv gddkviscsm 421 dgsvrlwslk qntllalsiv dgvpifagri sqdgqkyava fmdgqvnvyd lkklnsksrs 481 lygnrdgiln plpiplyasy qssqdndyif dlswncagnk isvayslqeg svvai // LOCUS NP_009662 329 aa linear PLN 30-JUN-2025 DEFINITION organic acid transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_009662 VERSION NP_009662.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178452.3 REFERENCE 1 (residues 1 to 329) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 329) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 329) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 329) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07223. On Jul 30, 2012 this sequence version replaced NP_009662.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..329 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..329 /product="organic acid transporter" /calculated_mol_wt="36424" Region 34..120 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 138..223 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 235..328 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..329 /gene="YMC2" /locus_tag="YBR104W" /coded_by="NM_001178452.3:1..990" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16140254|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:genetic interaction:GO:0005342 organic acid transmembrane transporter activity [PMID:16140254]" /experiment="EXISTENCE:genetic interaction:GO:0006839 mitochondrial transport [PMID:16140254]" /experiment="EXISTENCE:genetic interaction:GO:0055085 transmembrane transport [PMID:16140254]" /note="Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC2 has a paralog, YMC1, that arose from the whole genome duplication" /db_xref="GeneID:852401" /db_xref="SGD:S000000308" ORIGIN 1 mseefptpql ldeledqqkv ttpnekrels snrvlkdifa gtiggiaqvl vgqpfdttkv 61 rlqtattrtt tlevlrnlvk negvfafykg altpllgvgi cvsvqfgvne amkrffqnyn 121 asknpnmssq dvdlsrsntl plsqyyvcgl tggvvnsfla spieqirirl qtqtsnggdr 181 efkgpwdcik klkaqgglmr glfptmirag hglgtyflvy ealvareigt gltrneippw 241 klclfgafsg tmlwltvypl dvvksiiqnd dlrkpkykns isyvaktiya kegiraffkg 301 fgptmvrsap vngatfltfe lvmrflgee // LOCUS NP_009663 362 aa linear PLN 30-JUN-2025 DEFINITION glucose-induced degradation complex subunit VID24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009663 VERSION NP_009663.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178453.1 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 362) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07224. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..362 /product="glucose-induced degradation complex subunit VID24" /calculated_mol_wt="41114" Region 42..358 /region_name="VID24" /note="Vacuolar import and degradation protein [Intracellular trafficking and secretion]; COG5073" /db_xref="CDD:227405" CDS 1..362 /gene="VID24" /locus_tag="YBR105C" /gene_synonym="GID4" /coded_by="NM_001178453.1:1..1089" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0031410 cytoplasmic vesicle [PMID:9508768]" /experiment="EXISTENCE:direct assay:GO:0034657 GID complex [PMID:18508925|PMID:16872538]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:9508768|PMID:12730205]" /experiment="EXISTENCE:mutant phenotype:GO:0007039 protein catabolic process in the vacuole [PMID:9508768|PMID:15358789]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:15358789|PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]" /note="GID Complex regulatory subunit; binds GID Complex in response to glucose through interactions with complex member Vid28p; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase; peripheral membrane protein located at Vid (vacuole import and degradation) vesicles" /db_xref="GeneID:852402" /db_xref="SGD:S000000309" ORIGIN 1 minnpkvdsv aekpkavtsk qseqaaspep tpappvsrnq ypitfnltst apfhlhdrhr 61 ylqeqdlykc asrdslsslq qlahtpngst rkkyivedqs pyssenpviv tssynhtvct 121 nylrprmqft gyqisgykry qvtvnlktvd lpkkdctsls phlsgflsir gltnqhpeis 181 tyfeayavnh kelgflsssw kdepvlnefk atdqtdlehw infpsfrqlf lmsqknglns 241 tddngttnaa kklppqqlpt tpsadagnis rifsqekqfd nylnerfifm kwkekflvpd 301 allmegvdga sydgfyyivh dqvtgniqgf yyhqdaekfq qlelvpslkn kvessdcsfe 361 fa // LOCUS NP_009664 188 aa linear PLN 30-JUN-2025 DEFINITION Snd3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009664 VERSION NP_009664.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178454.1 REFERENCE 1 (residues 1 to 188) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 188) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 188) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 188) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07225. Method: conceptual translation. FEATURES Location/Qualifiers source 1..188 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..188 /product="Snd3p" /calculated_mol_wt="21006" Region 6..181 /region_name="Pho88" /note="Phosphate transport (Pho88); pfam10032" /db_xref="CDD:431002" CDS 1..188 /gene="SND3" /locus_tag="YBR106W" /gene_synonym="PHO88" /coded_by="NM_001178454.1:1..567" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:27905431]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:8709965]" /experiment="EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:27905431]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:19433630]" /note="Involved in SRP-independent protein targeting to the ER; component of an alternative ER-targeting pathway partially redundant with the GET pathway that can compensate for SRP loss; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Env10p/Snd2p, and Sec61p-translocon subunits; role in establishing nucleus-vacuole junctions (NVJs) in high glucose; targeted to the NVJ during glucose starvation to facilitate expansion; role in phosphate transport with Pho86p" /db_xref="GeneID:852403" /db_xref="SGD:S000000310" ORIGIN 1 mnpqvsniii mlvmmqlsrr idmedptiim yirilycssi giswiiyqma rkrivakndm 61 ttmkyvepgn amsgegeklq vttvrdydlk eidsaiksiy tgmammgfmh lylkytnplf 121 mqsispvksa lehnevkihl fgkpatgdlk rpfkapslfg gmgqtgpktd kksieeaera 181 gnagvkae // LOCUS NP_009665 245 aa linear PLN 30-JUN-2025 DEFINITION Iml3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009665 VERSION NP_009665.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178455.3 REFERENCE 1 (residues 1 to 245) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 245) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 245) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 245) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07226. On Jul 30, 2012 this sequence version replaced NP_009665.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..245 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..245 /product="Iml3p" /calculated_mol_wt="27935" Region 2..241 /region_name="IML3" /note="IML3 domain found in Saccharomyces cerevisiae inner kinetochore subunit IML3 and similar proteins; cd22875" /db_xref="CDD:439373" Site order(11,82,104..105,108,110,112,151..162,164..166,169, 172..173,191,193,195..197,202..203,240..241) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:439373" CDS 1..245 /gene="IML3" /locus_tag="YBR107C" /gene_synonym="MCM19" /coded_by="NM_001178455.3:1..738" /experiment="EXISTENCE:direct assay:GO:0000940 outer kinetochore [PMID:12589047]" /experiment="EXISTENCE:genetic interaction:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:15241623]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /experiment="EXISTENCE:mutant phenotype:GO:0034089 establishment of meiotic sister chromatid cohesion [PMID:19730685]" /experiment="EXISTENCE:mutant phenotype:GO:0034090 maintenance of meiotic sister chromatid cohesion [PMID:14752166]" /experiment="EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:15241623]" /experiment="EXISTENCE:mutant phenotype:GO:0071459 protein localization to chromosome, centromeric region [PMID:16357219|PMID:26653857]" /note="Outer kinetochore protein and component of the Ctf19 complex; involved in the establishment of pericentromeric cohesion during mitosis; prevents non-disjunction of sister chromatids during meiosis II; forms a stable complex with Chl4p; required for localization of Sgo1p to pericentric sites during meiosis I; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-L and fission yeast fta1" /db_xref="GeneID:852404" /db_xref="SGD:S000000311" ORIGIN 1 mpytwkflgi skqlslengi aklnqllnle vdldiqtirv psdpdggtaa deyiryemrl 61 disnldegty skfiflgnsk mevpmflcyc gtdnrnevvl qwlkaeygvi mwpikfeqkt 121 mikladasiv hvtkenieqi twfssklyfe petqdknlrq fsieipresc eglalgygnt 181 mhpyndaivp yiynetgmav erlpltsvil aghtkimres ivtstrslrn rvlavvlqsi 241 qftse // LOCUS NP_009666 947 aa linear PLN 30-JUN-2025 DEFINITION Aim3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009666 VERSION NP_009666.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178456.2 REFERENCE 1 (residues 1 to 947) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 947) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 947) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 947) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 947) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 947) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 947) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07227. On Apr 26, 2011 this sequence version replaced NP_009666.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..947 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..947 /product="Aim3p" /calculated_mol_wt="103732" Region 8..99 /region_name="AIM3" /note="Altered inheritance of mitochondria protein 3; pfam17096" /db_xref="CDD:407240" CDS 1..947 /gene="AIM3" /locus_tag="YBR108W" /coded_by="NM_001178456.2:1..2844" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:21035341]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:15561700]" /experiment="EXISTENCE:genetic interaction:GO:0000147 actin cortical patch assembly [PMID:21035341]" /experiment="EXISTENCE:mutant phenotype:GO:0051016 barbed-end actin filament capping [PMID:23333351]" /note="Protein that inhibits barbed-end actin filament elongation; interacts with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss" /db_xref="GeneID:852405" /db_xref="SGD:S000000312" ORIGIN 1 mgfwennkds itsglksagk ygyqgtkyva ktgykaskkh ynnskarrer ksgkknssde 61 eydsedemey erkptdirsl kdpksfpppp lkpgqktytg qqqqqmpngq asyafqgayq 121 gqpgagsteq sqyaqpqynq ypqqqlqqgv mpqqqqlqqg vvpqqppiyg eqvppygsns 181 natsyqslpq qnqpqnaips qvslnsasqq stgfvsqnlq ygtqssnpap spsfqnglqc 241 hqqpqyvshg stnlgqsqfp sgqqqqpttq fgqqvlpspa qpqqqqqgqp lppprgqvil 301 papgeplsng fgqqqqqqqq qqqplnqnna llpqmnvegv sgmaavqpvy gqamssttnm 361 qdsnpsygas pmqgqppvgg qppvpvrmqp qppqpmqqgn iypiepslds tgstphfevt 421 pfdpdapapk pkidiptvdv sslppppthr drgavvhqep apsgkiqpnt tssaaslpak 481 hsrtttadne rnsgnkende stskssilgh ydvdvnimpp pkpfrhglds vpsehttkna 541 peravpilpp rnnveppppp srgnfertes vlstnaanvq edpisnflpp pkpfrhtetk 601 qnqnskaspv emkgevlpgh pseedrnvep slvpqskpqs qsqfrrahme tqpiqnfqpp 661 pkpfrrsqss nssdssytid gpeanhgrgr griakhhdgd eynpksenst engrlgdapn 721 sfirkraptp papsrseklh egtitsevds skdankyeks ippvtssiqa qqstkkappp 781 vvkpkprnfs lkaneypkel treatgqdev lnsitnelsh iklrktnvnl eklggskkvk 841 dsspvpsdld ekyvsasgsi tpprpppsrs spkkvppvvp kkndnlkkkp pvvpkkkpll 901 ksleprpiem eraysgdisa addnlnpfer ykrnvvpqed drlhklk // LOCUS NP_009667 147 aa linear PLN 30-JUN-2025 DEFINITION calmodulin [Saccharomyces cerevisiae S288C]. ACCESSION NP_009667 VERSION NP_009667.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178457.1 REFERENCE 1 (residues 1 to 147) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 147) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 147) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 147) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07228. Method: conceptual translation. FEATURES Location/Qualifiers source 1..147 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..147 /product="calmodulin" /calculated_mol_wt="16004" Region 1..145 /region_name="PTZ00184" /note="calmodulin; Provisional" /db_xref="CDD:185504" CDS 1..147 /gene="CMD1" /locus_tag="YBR109C" /coded_by="NM_001178457.1:1..444" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:1639847]" /experiment="EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:8461293|PMID:3533275]" /experiment="EXISTENCE:direct assay:GO:0005823 central plaque of spindle pole body [PMID:8886974|PMID:8601600]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:1639847]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:1639847]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:9859992]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:1639847]" /experiment="EXISTENCE:direct assay:GO:0048306 calcium-dependent protein binding [PMID:1321337]" /experiment="EXISTENCE:direct assay:GO:1903525 regulation of membrane tubulation [PMID:27093085]" /experiment="EXISTENCE:genetic interaction:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:12836012]" /experiment="EXISTENCE:genetic interaction:GO:0006661 phosphatidylinositol biosynthetic process [PMID:12079494]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:12836012]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:17878171]" /experiment="EXISTENCE:mutant phenotype:GO:0006661 phosphatidylinositol biosynthetic process [PMID:12079494]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:27093085]" /experiment="EXISTENCE:mutant phenotype:GO:0006898 receptor-mediated endocytosis [PMID:7988551|PMID:9450989]" /experiment="EXISTENCE:mutant phenotype:GO:0007010 cytoskeleton organization [PMID:8310294]" /experiment="EXISTENCE:mutant phenotype:GO:0007114 cell budding [PMID:8310294]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:16055436]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:9859992]" /experiment="EXISTENCE:mutant phenotype:GO:0051300 spindle pole body organization [PMID:1469052]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:8294515|PMID:9450989|PMID:9950677|PMID:10749918]" /experiment="EXISTENCE:physical interaction:GO:0048306 calcium-dependent protein binding [PMID:9756868]" /experiment="EXISTENCE:physical interaction:GO:0051019 mitogen-activated protein kinase binding [PMID:27421986]" /experiment="EXISTENCE:physical interaction:GO:0071474 cellular hyperosmotic response [PMID:27421986]" /note="Calmodulin; Ca2+ binding protein that regulates Ca2+ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca2+ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin; binds to the Hog1p MAPK in response to hyperosmotic stress; potentiates membrane tubulation and constriction mediated by the Rvs161p-Rvs167p complex; human CALM1 or CALM2 functionally complement repression induced inviability" /db_xref="GeneID:852406" /db_xref="SGD:S000000313" ORIGIN 1 mssnlteeqi aefkeafalf dkdnngsiss selatvmrsl glspseaevn dlmneidvdg 61 nhqiefsefl almsrqlksn dseqelleaf kvfdkngdgl isaaelkhvl tsigekltda 121 evddmlrevs dgsgeiniqq faallsk // LOCUS NP_009668 449 aa linear PLN 30-JUN-2025 DEFINITION chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009668 VERSION NP_009668.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178458.3 REFERENCE 1 (residues 1 to 449) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 449) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 449) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 449) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07229. On Jul 30, 2012 this sequence version replaced NP_009668.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..449 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..449 /product="chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase" /EC_number="2.4.1.142" /calculated_mol_wt="51798" Region 36..445 /region_name="GT33_ALG1-like" /note="chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins; cd03816" /db_xref="CDD:340843" CDS 1..449 /gene="ALG1" /locus_tag="YBR110W" /coded_by="NM_001178458.3:1..1350" /experiment="EXISTENCE:direct assay:GO:0019187 beta-1,4-mannosyltransferase activity [PMID:6368538]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:6369318]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:7037780]" /experiment="EXISTENCE:physical interaction:GO:0005783 endoplasmic reticulum [PMID:15044395]" /note="Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant" /db_xref="GeneID:852407" /db_xref="SGD:S000000314" ORIGIN 1 mfleiprwll aliilylsip lvvyyvipyl fygnkstkkr iiifvlgdvg hspricyhai 61 sfsklgwqve lcgyvedtlp kiissdpnit vhhmsnlkrk gggtsvifmv kkvlfqvlsi 121 fkllwelrgs dyilvqnpps ipilpiavly kltgckliid whnlaysilq lkfkgnfyhp 181 lvlisymvem ifskfadynl tvteamrkyl iqsfhlnpkr cavlydrpas qfqplagdis 241 rqkalttkaf iknyirddfd tekgdkiivt stsftpdedi gillgalkiy ensyvkfdss 301 lpkilcfitg kgplkekymk qveeydwkrc qiefvwlsae dypkllqlcd ygvslhtsss 361 gldlpmkild mfgsglpvia mnypvldelv qhnvnglkfv drrelhesli famkdadlyq 421 klkknvtqea enrwqsnwer tmrdlklih // LOCUS NP_009669 231 aa linear PLN 30-JUN-2025 DEFINITION ADP-ribose diphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009669 VERSION NP_009669.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178459.1 REFERENCE 1 (residues 1 to 231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 231) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07230. Method: conceptual translation. FEATURES Location/Qualifiers source 1..231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..231 /product="ADP-ribose diphosphatase" /EC_number="3.6.1.13" /calculated_mol_wt="25956" Region 76..222 /region_name="NUDIX_ADPRase_Nudt5" /note="ADP-ribose pyrophosphatase; cd18888" /db_xref="CDD:467598" CDS 1..231 /gene="YSA1" /locus_tag="YBR111C" /gene_synonym="RMA2" /coded_by="NM_001178459.1:1..696" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:19251690]" /experiment="EXISTENCE:direct assay:GO:0019693 ribose phosphate metabolic process [PMID:10542272|PMID:12370179]" /experiment="EXISTENCE:direct assay:GO:0047631 ADP-ribose diphosphatase activity [PMID:10542272]" /note="Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate" /db_xref="GeneID:852408" /db_xref="SGD:S000000315" ORIGIN 1 mflrnvrvis lnsrrlfrtm stvkgkpeda kiiearhvke tsdckwiglq kiiykdpngk 61 erewdsavrt trssggvdgi giltilkykd gkpdeillqk qfrppvegvc iempaglida 121 gedidtaalr elkeetgysg kiisksptvf ndpgftntnl clvtvevdms lpenqkpvtq 181 lednefiecf svelhkfpde mvkldqqgyk ldarvqnvaq gilmakqyhi k // LOCUS NP_878049 96 aa linear PLN 30-JUN-2025 DEFINITION Sus1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878049 VERSION NP_878049.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184520.1 REFERENCE 1 (residues 1 to 96) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 96) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 96) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 96) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07231. On Feb 2, 2004 this sequence version replaced NP_878049.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..96 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..96 /product="Sus1p" /calculated_mol_wt="10953" Region 12..88 /region_name="EnY2" /note="Transcription factor e(y)2; pfam10163" /db_xref="CDD:462972" CDS 1..96 /gene="SUS1" /locus_tag="YBR111W-A" /coded_by="NM_001184520.1:1..291" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:14718168]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:29598828]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:14718168]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:14718168]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:18488019]" /experiment="EXISTENCE:direct assay:GO:0070390 transcription export complex 2 [PMID:15311284]" /experiment="EXISTENCE:direct assay:GO:0071819 DUBm complex [PMID:20395473]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:18003937]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:18667528]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:14718168]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:19269973]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14718168]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:18003937]" /note="Global transcriptional regulator, component of SAGA, TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to nuclear periphery and to non-nascent mRNP; plays role in negatively regulating telomere length through modulation of H2BK123 mono-ubiquitination and its interaction with nuclear pore complex" /db_xref="GeneID:1466445" /db_xref="SGD:S000028510" ORIGIN 1 mtmdtaqlks qiqqylvesg nyelisnelk arllqegwvd kvkdltksem ninestnftq 61 ilstvepkal emvsdstret vlkqirefle eivdtq // LOCUS NP_009670 966 aa linear PLN 30-JUN-2025 DEFINITION transcription regulator CYC8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009670 VERSION NP_009670.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178460.3 REFERENCE 1 (residues 1 to 966) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 966) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 966) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 966) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 966) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 966) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 966) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07232. On Jul 30, 2012 this sequence version replaced NP_009670.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..966 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..966 /product="transcription regulator CYC8" /calculated_mol_wt="107071" Region 46..326 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 46..74 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 80..108 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(81,84..85,88..89,91,115,118..119,122..123,125..126, 151,154..155,158..159,162) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 113..143 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 150..178 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 184..211 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 223..253 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 251..>414 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" Region 258..290 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 296..324 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(297,300..301,304..305,307,331,334..335,338..339, 341..342,365,368..369,372..373,377) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 329..359 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 364..393 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 695..>910 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" CDS 1..966 /gene="CYC8" /locus_tag="YBR112C" /gene_synonym="CRT8; SSN6" /coded_by="NM_001178460.3:1..2901" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:9867831]" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9741624]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1739976]" /experiment="EXISTENCE:direct assay:GO:0042826 histone deacetylase binding [PMID:14525981]" /experiment="EXISTENCE:genetic interaction:GO:0003713 transcription coactivator activity [PMID:9867831]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577|PMID:18708352|PMID:9560430]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:9560430]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:14739928]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9280286]" /experiment="EXISTENCE:mutant phenotype:GO:0042304 regulation of fatty acid biosynthetic process [PMID:9280286]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:26546823]" /experiment="EXISTENCE:mutant phenotype:GO:2000879 negative regulation of dipeptide transport [PMID:18708352]" /experiment="EXISTENCE:physical interaction:GO:0003713 transcription coactivator activity [PMID:9867831]" /experiment="EXISTENCE:physical interaction:GO:0003714 transcription corepressor activity [PMID:9741624]" /experiment="EXISTENCE:physical interaction:GO:0017053 transcription repressor complex [PMID:9111019]" /note="Transcriptional regulator; functions primarily as a transcriptional co-repressor with Tup1p but can also function as a transcriptional co-activator with Tup1p that recruits the SWI/SNF and SAGA complexes to promoters; target genes may be uniquely repressed by Cyc8p or Tup1p, subject to redundant repression, or in some cases de-repression of target genes in a cyc8 mutant is dependent upon TUP1 and vice versa; can form the prion [OCT+]" /db_xref="GeneID:852410" /db_xref="SGD:S000000316" ORIGIN 1 mnpggeqtim eqpaqqqqqq qqqqqqqqqq aavpqqpldp ltqstaetwl siaslaetlg 61 dgdraamayd atlqfnpssa kaltslahly rsrdmfqraa elyerallvn pelsdvwatl 121 ghcylmlddl qraynayqqa lyhlsnpnvp klwhgigily drygsldyae eafakvleld 181 phfekaneiy frlgiiykhq gkwsqalecf ryilpqppap lqewdiwfql gsvlesmgew 241 qgakeayehv laqnqhhakv lqqlgclygm snvqfydpqk aldyllksle adpsdattwy 301 hlgrvhmirt dytaaydafq qavnrdsrnp ifwcsigvly yqisqyrdal daytrairln 361 pyisevwydl gtlyetcnnq lsdaldaykq aarldvnnvh irerlealtk qlenpgnink 421 sngaptnasp apppvilqpt lqpndqgnpl ntrisaqsan atasmvqqqh paqqtpinss 481 atmysngasp qlqaqaqaqa qaqaqaqaqa qaqaqaqaqa qaqaqaqaqa qaqaqahaqa 541 qaqaqaqaqa qaqaqaqqqq qqqqqqqqqq qqqqqqqqqq qqqqqqqlqp lprqqlqqkg 601 vsvqmlnpqq gqpyitqptv iqahqlqpfs tqamehpqss qlppqqqqlq svqhpqqlqg 661 qpqaqapqpl iqhnveqnvl pqkrymegai htlvdaavss sthtenntks prqpthaipt 721 qapatgitna epqvkkqkln spnsninklv ntatsieena ksevsnqspa vvesntnnts 781 qeekpvkans ipsvigaqep pqeaspaeea tkaasvspst kplntepess svqptvsses 841 sttkandqst aetielstat vpaeaspved evrqhskeen gtteasapst eeaepaasrd 901 aekqqdetaa ttitvikptl etmetvkeea kmreeeqtsq ekspqentlp renvvrqvee 961 denydd // LOCUS NP_009672 790 aa linear PLN 30-JUN-2025 DEFINITION DNA repair protein RAD16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009672 VERSION NP_009672.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178462.1 REFERENCE 1 (residues 1 to 790) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 790) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 790) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 790) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07233. Method: conceptual translation. FEATURES Location/Qualifiers source 1..790 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..790 /product="DNA repair protein RAD16" /calculated_mol_wt="91300" Region <172..769 /region_name="HepA" /note="Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair]; COG0553" /db_xref="CDD:440319" Region 536..584 /region_name="RING-HC_RAD16-like" /note="RING finger, HC subclass, found in Saccharomyces cerevisiae DNA repair protein RAD16, Schizosaccharomyces pombe rhp16, and similar proteins; cd16567" /db_xref="CDD:438229" CDS 1..790 /gene="RAD16" /locus_tag="YBR114W" /gene_synonym="PSO5" /coded_by="NM_001178462.1:1..2373" /experiment="EXISTENCE:direct assay:GO:0000113 nucleotide-excision repair factor 4 complex [PMID:9497356]" /experiment="EXISTENCE:direct assay:GO:0000715 nucleotide-excision repair, DNA damage recognition [PMID:15177043]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:16675952]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:9497356]" /experiment="EXISTENCE:direct assay:GO:0008104 intracellular protein localization [PMID:15226437]" /experiment="EXISTENCE:direct assay:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:16675952]" /experiment="EXISTENCE:mutant phenotype:GO:0000715 nucleotide-excision repair, DNA damage recognition [PMID:15177043]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:16675952]" /note="Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad7p) during NER; required for NER of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex" /db_xref="GeneID:852411" /db_xref="SGD:S000000318" ORIGIN 1 mqeggfirrr rtrstkksvn ynelsdddta vknsktlqlk gnsenvndsq deeyrddatl 61 vkspddddkd fiidltgsdk ertatdenth aikndndeii eikeerdvsd ddepltkkrk 121 ttarkkkkkt stkkkspkvt pyerntlrly ehhpelrnvf tdlknappyv pqrskqpdgm 181 tikllpfqle glhwlisqee siyaggvlad emgmgktiqt iallmndltk spslvvaptv 241 almqwkneie qhtkgqlkiy iyhgasrttd ikdlqgydvv lttyavlesv frkqnygfrr 301 knglfkqpsv lhnidfyrvi ldeahnikdr qsntaravnn lktqkrwcls gtplqnrige 361 myslirflni npftkyfctk cdcaskdwkf tdrmhcdhcs hvimqhtnff nhfmlkniqk 421 fgvegpgles fnniqtllkn imlrrtkver addlglppri vtvrrdffne eekdlyrsly 481 tdskrkynsf veegvvlnny aniftlitrm rqladhpdlv lkrlnnfpgd digvvicqlc 541 ndeaeepies kchhkfcrlc ikeyvesfme nnnkltcpvc higlsidlsq palevdldsf 601 kkqsivsrln msgkwqsstk iealveelyk lrsnkrtiks ivfsqftsml dlvewrlkra 661 gfqtvklqgs msptqrdeti kyfmnniqce vflvslkagg valnlceasq vfildpwwnp 721 svewqsgdrv hrigqyrpvk itrfciedsi eariielqek kanmihatin qdeaaisrlt 781 padlqflfnn // LOCUS NP_009673 1392 aa linear PLN 30-JUN-2025 DEFINITION L-aminoadipate-semialdehyde dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009673 VERSION NP_009673.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178463.1 REFERENCE 1 (residues 1 to 1392) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1392) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1392) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1392) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07234. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1392 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1392 /product="L-aminoadipate-semialdehyde dehydrogenase" /EC_number="1.2.1.31" /EC_number="1.2.1.95" /calculated_mol_wt="155215" Region 7..1379 /region_name="alpha_am_amid" /note="L-aminoadipate-semialdehyde dehydrogenase; TIGR03443" /db_xref="CDD:274582" CDS 1..1392 /gene="LYS2" /locus_tag="YBR115C" /coded_by="NM_001178463.1:1..4179" /experiment="EXISTENCE:direct assay:GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity [PMID:10320345]" /experiment="EXISTENCE:direct assay:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:10320345]" /experiment="EXISTENCE:mutant phenotype:GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity [PMID:4401608|PMID:3023949]" /experiment="EXISTENCE:mutant phenotype:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:3023949|PMID:4401608]" /note="Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p" /db_xref="GeneID:852412" /db_xref="SGD:S000000319" ORIGIN 1 mtnekvwiek ldnptlsvlp hdflrpqqep ytkqatyslq lpqldvphds fsnkyavals 61 vwaaliyrvt gdddivlyia nnkilrfniq ptwsfnelys tinnelnkln sieanfsfde 121 laekiqscqd lertpqlfrl aflenqdfkl defkhhlvdf alnldtsnna hvlnliynsl 181 lysnervtiv adqftqylta alsdpsncit kislitassk dslpdptknl gwcdfvgcih 241 difqdnaeaf pertcvvetp tlnsdksrsf tyrdinrtsn ivahyliktg ikrgdvvmiy 301 ssrgvdlmvc vmgvlkagat fsvidpaypp arqtiylgva kprglivira agqldqlved 361 yindeleivs rinsiaiqen gtieggkldn gedvlapydh ykdtrtgvvv gpdsnptlsf 421 tsgsegipkg vlgrhfslay yfnwmskrfn ltendkftml sgiahdpiqr dmftplflga 481 qlyvptqddi gtpgrlaewm skygctvthl tpamgqllta qattpfpklh haffvgdilt 541 krdclrlqtl aencrivnmy gttetqravs yfevkskndd pnflkklkdv mpagkgmlnv 601 qllvvnrndr tqicgigeig eiyvraggla egyrglpeln kekfvnnwfv ekdhwnyldk 661 dngepwrqfw lgprdrlyrt gdlgrylpng dceccgradd qvkirgfrie lgeidthisq 721 hplvrenitl vrknadnept litfmvprfd kpddlskfqs dvpkevetdp ivkgligyhl 781 lskdirtflk krlasyamps livvmdklpl npngkvdkpk lqfptpkqln lvaentvset 841 ddsqftnver evrdlwlsil ptkpasvspd dsffdlgghs ilatkmiftl kkklqvdlpl 901 gtifkyptik afaaeidrik ssggssqgev venvtanyae dakklvetlp ssypsreyfv 961 epnsaegktt invfvtgvtg flgsyiladl lgrspknysf kvfahvrakd eeaafarlqk 1021 agitygtwne kfasnikvvl gdlsksqfgl sdekwmdlan tvdiiihnga lvhwvypyak 1081 lrdpnvisti nvmslaavgk pkffdfvsst stldteyyfn lsdklvsegk pgilesddlm 1141 nsasgltggy gqskwaaeyi irragerglr gcivrpgyvt gasangssnt ddfllrflkg 1201 svqlgkipdi ensvnmvpvd hvarvvvats lnppkenela vaqvtghpri lfkdylytlh 1261 dygydveies yskwkkslea svidrneena lypllhmvld nlpestkape lddrnavasl 1321 kkdtawtgvd wsngigvtpe evgiyiafln kvgflpppth ndklplpsie ltqaqislva 1381 sgagargssa aa // LOCUS NP_009675 681 aa linear PLN 30-JUN-2025 DEFINITION transketolase TKL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009675 VERSION NP_009675.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178465.3 REFERENCE 1 (residues 1 to 681) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 681) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 681) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 681) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 681) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 681) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 681) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07235. On Jul 30, 2012 this sequence version replaced NP_009675.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..681 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..681 /product="transketolase TKL2" /EC_number="2.2.1.1" /calculated_mol_wt="74899" Region 9..665 /region_name="tktlase_bact" /note="transketolase, bacterial and yeast; TIGR00232" /db_xref="CDD:272974" CDS 1..681 /gene="TKL2" /locus_tag="YBR117C" /coded_by="NM_001178465.3:1..2046" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006098 pentose-phosphate shunt [PMID:7916691]" /note="Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL2 has a paralog, TKL1, that arose from the whole genome duplication" /db_xref="GeneID:852414" /db_xref="SGD:S000000321" ORIGIN 1 maqfsdidkl avstlrllsv dqvesaqsgh pgaplglapv ahvifkqlrc npnnehwinr 61 drfvlsnghs callysmlhl lgydysiedl rqfrqvnsrt pghpefhsag veitsgplgq 121 gisnavgmai aqanfaatyn edgfpisdsy tfaivgdgcl qegvssetss laghlqlgnl 181 itfydsnsis idgktsysfd edvlkryeay gwevmevdkg dddmesissa lekaklskdk 241 ptiikvttti gfgslqqgta gvhgsalkad dvkqlkkrwg fdpnksfvvp qevydyykkt 301 vvepgqklne ewdrmfeeyk tkfpekgkel qrrlngelpe gwekhlpkft pdddalatrk 361 tsqqvltnmv qvlpeliggs adltpsnltr wegavdfqpp itqlgnyagr yirygvrehg 421 mgaimngisa fganykpygg tflnfvsyaa gavrlaalsg npviwvathd siglgedgpt 481 hqpietlahl raipnmhvwr padgnetsaa yysaiksgrt psvvalsrqn lpqlehssfe 541 kalkggyvih dvenpdiilv stgsevsisi daakklydtk kikarvvslp dfytfdrqse 601 eyrfsvlpdg vpimsfevla tsswgkyahq sfgldefgrs gkgpeiyklf dftadgvasr 661 aektinyykg kqllspmgra f // LOCUS NP_009676 458 aa linear PLN 30-JUN-2025 DEFINITION translation elongation factor EF-1 alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_009676 VERSION NP_009676.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178466.1 REFERENCE 1 (residues 1 to 458) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 458) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 458) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 458) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07236. Method: conceptual translation. FEATURES Location/Qualifiers source 1..458 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..458 /product="translation elongation factor EF-1 alpha" /calculated_mol_wt="49902" Region 1..443 /region_name="PTZ00141" /note="elongation factor 1- alpha; Provisional" /db_xref="CDD:185474" Site 14..21 /site_type="other" /note="G1 box" /db_xref="CDD:206670" Site order(15,17,21..22,25,28..29,76..77,95..96,119..120,167, 171) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206670" Site order(17,19..22,153..154,156,192..194) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206670" Site order(21,64,67..68,70,72,74..76,78,89,91,93..95,97,100) /site_type="other" /note="EF1Balpha binding site [polypeptide binding]" /db_xref="CDD:206670" Site 66..76 /site_type="other" /note="Switch I region" /db_xref="CDD:206670" Site 72 /site_type="other" /note="G2 box" /db_xref="CDD:206670" Site 91..94 /site_type="other" /note="G3 box" /db_xref="CDD:206670" Site 93..111 /site_type="other" /note="Switch II region" /db_xref="CDD:206670" Site 153..156 /site_type="other" /note="G4 box" /db_xref="CDD:206670" Site 192..194 /site_type="other" /note="G5 box" /db_xref="CDD:206670" CDS 1..458 /gene="TEF2" /locus_tag="YBR118W" /coded_by="NM_001178466.1:1..1377" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0003746 translation elongation factor activity [PMID:10514524]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:10514524]" /note="Translational elongation factor EF-1 alpha; GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; moonlighting function as an actin binding and bundling protein; association with GTPase Rho1p on the vacuolar membrane may facilitate F-actin remodeling; involved in tRNA re-export from the nucleus; Tef2p-RFP levels increase during replicative aging" /db_xref="GeneID:852415" /db_xref="SGD:S000000322" ORIGIN 1 mgkekshinv vvighvdsgk stttghliyk cggidkrtie kfekeaaelg kgsfkyawvl 61 dklkaererg itidialwkf etpkyqvtvi dapghrdfik nmitgtsqad cailiiaggv 121 gefeagiskd gqtrehalla ftlgvrqliv avnkmdsvkw desrfqeivk etsnfikkvg 181 ynpktvpfvp isgwngdnmi eattnapwyk gweketkagv vkgktlleai daieqpsrpt 241 dkplrlplqd vykiggigtv pvgrvetgvi kpgmvvtfap agvttevksv emhheqleqg 301 vpgdnvgfnv knvsvkeirr gnvcgdaknd ppkgcasfna tvivlnhpgq isagyspvld 361 chtahiacrf dellekndrr sgkkledhpk flksgdaalv kfvpskpmcv eafseypplg 421 rfavrdmrqt vavgviksvd ktekaakvtk aaqkaakk // LOCUS NP_009677 298 aa linear PLN 30-JUN-2025 DEFINITION Mud1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009677 VERSION NP_009677.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178467.1 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 298) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07237. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..298 /product="Mud1p" /calculated_mol_wt="34247" Region <61..112 /region_name="RRM_SF" /note="RNA recognition motif (RRM) superfamily; cl17169" /db_xref="CDD:473069" Region 225..295 /region_name="RRM2_U1A_like" /note="RNA recognition motif 2 (RRM2) found in the U1A/U2B'/SNF protein family; cd12247" /db_xref="CDD:409693" CDS 1..298 /gene="MUD1" /locus_tag="YBR119W" /coded_by="NM_001178467.1:1..897" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:8449403]" /experiment="EXISTENCE:genetic interaction:GO:0030619 U1 snRNA binding [PMID:8449403]" /experiment="EXISTENCE:physical interaction:GO:0030619 U1 snRNA binding [PMID:8849781]" /note="U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing" /db_xref="GeneID:852416" /db_xref="SGD:S000000323" ORIGIN 1 msalyfqnlp srpankenyt rlllkhinpn nkyainpslp lphnklqiss qplmllddqm 61 gllevsisrs skmtnqaflt fvtqeeadrf lekytttalk vqgrkvrmgk artnsllgls 121 iemqkkkgnd etynldikkv lkarklkrkl rsddicakkf rlkrqirrlk hklrsrkvee 181 aeidrivkef etrrlenmks qqenlkqsqk plkrakvsnt menppnkvll iqnlpsgtte 241 qllsqilgne alveirlvsv rnlafveyet vadatkiknq lgstyklqnn dvtigfak // LOCUS NP_009678 162 aa linear PLN 30-JUN-2025 DEFINITION Cbp6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009678 VERSION NP_009678.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178468.3 REFERENCE 1 (residues 1 to 162) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 162) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 162) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 162) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07238. On Jul 30, 2012 this sequence version replaced NP_009678.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..162 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..162 /product="Cbp6p" /calculated_mol_wt="18548" CDS 1..162 /gene="CBP6" /locus_tag="YBR120C" /coded_by="NM_001178468.3:1..489" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005761 mitochondrial ribosome [PMID:21670217]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:21670217]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:21670217]" /experiment="EXISTENCE:physical interaction:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:21670217]" /experiment="EXISTENCE:physical interaction:GO:0043022 ribosome binding [PMID:21670217]" /experiment="EXISTENCE:physical interaction:GO:0061671 Cbp3p-Cbp6 complex [PMID:21670217]" /note="Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation" /db_xref="GeneID:852417" /db_xref="SGD:S000000324" ORIGIN 1 msssqvvrds akklvnllek ypkdrihhlv sfrdvqiarf rrvaglpnvd dkgksikekk 61 psldeiksii nrtsgplgln kemltkiqnk mvdekftees ineqiralst imnnkfrnyy 121 digdklykpa gnpqyyqrli navdgkkkes lftamrtvlf gk // LOCUS NP_009679 667 aa linear PLN 30-JUN-2025 DEFINITION glycine--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009679 VERSION NP_009679.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178469.2 REFERENCE 1 (residues 1 to 667) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 667) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 667) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 667) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07239. On Apr 26, 2011 this sequence version replaced NP_009679.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..667 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..667 /product="glycine--tRNA ligase" /EC_number="6.1.1.14" /calculated_mol_wt="75208" Region 15..640 /region_name="glyS_dimeric" /note="glycyl-tRNA synthetase, dimeric type; TIGR00389" /db_xref="CDD:273051" CDS 1..667 /gene="GRS1" /locus_tag="YBR121C" /coded_by="NM_001178469.2:1..2004" /experiment="EXISTENCE:direct assay:GO:0004820 glycine-tRNA ligase activity [PMID:21877692]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:mutant phenotype:GO:0004820 glycine-tRNA ligase activity [PMID:10874035]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:10874035]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:10874035]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:10224248]" /experiment="EXISTENCE:mutant phenotype:GO:0006426 glycyl-tRNA aminoacylation [PMID:10874035]" /experiment="EXISTENCE:mutant phenotype:GO:0070150 mitochondrial glycyl-tRNA aminoacylation [PMID:10874035]" /note="Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication; human homolog GARS implicated in Charcot-Marie-Tooth disease, can complement yeast null mutant" /db_xref="GeneID:852418" /db_xref="SGD:S000000325" ORIGIN 1 msvedikkar aavpfnreql esvlrgrffy apafdlyggv sglydygppg cafqnniida 61 wrkhfileed mlevdctmlt pyevlktsgh vdkfsdwmcr dlktgeifra dhlveevlea 121 rlkgdqearg lvedanaaak ddaekkkrkk kvkqikavkl dddvvkeyee ilakidgysg 181 pelgelmeky dignpvtget lesprafnlm fetaigpsgq lkgylrpeta qgqflnfnkl 241 lefnnsktpf asasigksfr neispragll rvreflmaei ehfvdpldks hpkfneikdi 301 klsflprdvq eagstepivk tvgeavasrm vdnetlgyfi ariyqflmki gvdesklrfr 361 qhmanemahy aadcwdgelk tsygwiecvg cadrsaydlt vhskktkekl vvrqkldnpi 421 evtkweidlt kklfgpkfrk dapkveshll nmsqddlask aellkangkf tikvdgvdge 481 velddklvki eqrtkvehvr eyvpsvieps fgigriiysv fehsfwnrpe dnarsvlsfp 541 plvaptkvll vplsnhkdlv pvttevakil rksqipfkid dsgvsigkry arndelgtpf 601 gvtidfesak dhsvtlrerd stkqvrgsve nvikairdit yngasweegt kdltpfiaqa 661 eaeaetd // LOCUS NP_009680 177 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL31m MRPL36 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009680 VERSION NP_009680.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178470.1 REFERENCE 1 (residues 1 to 177) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 177) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 177) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 177) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07240. On Oct 2, 2003 this sequence version replaced NP_009680.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..177 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..177 /product="mitochondrial 54S ribosomal protein bL31m MRPL36" /calculated_mol_wt="19960" Region 42..108 /region_name="rpmE" /note="50S ribosomal protein L31; Reviewed; cl00377" /db_xref="CDD:469748" CDS 1..177 /gene="MRPL36" /locus_tag="YBR122C" /gene_synonym="bL31m" /coded_by="NM_001178470.1:1..534" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:19339279]" /note="Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region" /db_xref="GeneID:852419" /db_xref="SGD:S000000326" ORIGIN 1 mlksifakrf astgsypgst ritlprrpak kiqlgksrpa iyhqfnvkme lsdgsvvirr 61 sqypkgeirl iqdqrnnplw npsrddlvvv dansggsldr fnkrysslfs vdsttpnsss 121 etvelseenk kktqikkeek edvsekafgm ddylslldds eqqiksgkla skkrdkk // LOCUS NP_009681 649 aa linear PLN 30-JUN-2025 DEFINITION transcription factor TFIIIC subunit TFC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009681 VERSION NP_009681.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178471.3 REFERENCE 1 (residues 1 to 649) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 649) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 649) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 649) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07241. On Jul 30, 2012 this sequence version replaced NP_009681.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..649 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..649 /product="transcription factor TFIIIC subunit TFC1" /calculated_mol_wt="73423" Region 37..167 /region_name="Tau95_N" /note="Tau95 Triple barrel domain; pfam17682" /db_xref="CDD:465457" Region 227..391 /region_name="Tau95" /note="RNA polymerase III transcription factor (TF)IIIC subunit HTH domain; pfam09734" /db_xref="CDD:462865" CDS 1..649 /gene="TFC1" /locus_tag="YBR123C" /coded_by="NM_001178471.3:1..1950" /experiment="EXISTENCE:direct assay:GO:0000127 transcription factor TFIIIC complex [PMID:2180956|PMID:2002052|PMID:2052571|PMID:1474578]" /experiment="EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2649882|PMID:2404611]" /experiment="EXISTENCE:direct assay:GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding [PMID:2404611]" /experiment="EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:3633923|PMID:8464480]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2002052]" /experiment="EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2183033]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:12533520]" /note="Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63" /db_xref="GeneID:852421" /db_xref="SGD:S000000327" ORIGIN 1 mpveeplatl ssipdssadq appliadeft ldlpripsle lplnvstkhs siqkaikmcg 61 giekvkeafk ehgpiesqhg lqlylnddtd sdgsksyfne hpvigkrvpf rdesvilkvt 121 mpkgtlsknn nsvkdsiksl kdsnklrvtp vsivdntikf remsdfqikl dnvpsarefk 181 ssfgslewnn fksfvnsvpd ndsqpqenig nlildrsvki pstdfqlppp pklsmvgfpl 241 lykykanpfa kkkkngvtev kgtyiknyql fvhdlsdktv ipsqaheqvl ydfevakktk 301 vypgtksdsk fyesleeclk ilrelfarrp iwvkrhldgi vpkkihhtmk ialalisyrf 361 tmgpwrntyi kfgidprssv eyaqyqteyf kierkllssp ivkknvpkpp plvfesdtpg 421 gidsrfkfdg kripwylmlq idlligepni aevfhnveyl dkaneltgwf keldlvkirr 481 ivkyelgcmv qgnyeynkyk lkyfktmlfv kesmvpenkn seegmgvntn kdadgdinmd 541 agsqmssnai eedkgiaagd dfddngaite epddaalene emdtdqnlkv pasidddvdd 601 vdadeeeqes fdvktasfqd iinkiakldp ktaetmksel kgfvdevdl // LOCUS NP_009683 393 aa linear PLN 30-JUN-2025 DEFINITION type 2C protein phosphatase PTC4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009683 VERSION NP_009683.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178473.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 393) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07242. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..393 /product="type 2C protein phosphatase PTC4" /EC_number="3.1.3.16" /calculated_mol_wt="44045" Site order(43,47..48,83..85,310,359) /site_type="active" /db_xref="CDD:238083" Region 82..355 /region_name="PP2C" /note="Protein phosphatase 2C; pfam00481" /db_xref="CDD:395385" CDS 1..393 /gene="PTC4" /locus_tag="YBR125C" /gene_synonym="GCT1" /coded_by="NM_001178473.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:10580002]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006470 protein dephosphorylation [PMID:10580002]" /note="Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity" /db_xref="GeneID:852422" /db_xref="SGD:S000000329" ORIGIN 1 mgqllshplt ektieyneyk nnqastgivp rfyncvgsmq gyrltqedah lirnensvvy 61 vrffnpfidk yetlslnvfa vfdghggddc skflsggrhh rdgngssngn gepnaglikw 121 iaysfenhhy tsttnndssk fkrsfntleg lvsqifkdaf ilqdeelyrh fansscgsta 181 vvaciinees lyvancgdsr cilssksngi ktmsfdhkpq higelirind nggtvslgrv 241 ggvlalsraf sdfqfkrgvt yphrrtkltn itqnltygtp pqeaqvtvep dvlmhkidys 301 kdeflvlacd giwdiynnkq lihfikyhlv sgtkldtiit klldhgiaqa nsntgvgfdn 361 mtaiivvlnr kgetlqdwfn kmktrlerer glv // LOCUS NP_009684 495 aa linear PLN 30-JUN-2025 DEFINITION alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009684 VERSION NP_009684.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178474.1 REFERENCE 1 (residues 1 to 495) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 495) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 495) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 495) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07243. Method: conceptual translation. FEATURES Location/Qualifiers source 1..495 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..495 /product="alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1" /EC_number="2.4.1.15" /calculated_mol_wt="56017" Region 17..481 /region_name="trehalose_OtsA" /note="alpha,alpha-trehalose-phosphate synthase [UDP-forming]; TIGR02400" /db_xref="CDD:274112" CDS 1..495 /gene="TPS1" /locus_tag="YBR126C" /gene_synonym="BYP1; CIF1; FDP1; GGS1; GLC6; TSS1" /coded_by="NM_001178474.1:1..1488" /experiment="EXISTENCE:direct assay:GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [PMID:1425702]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [PMID:1425702]" /experiment="EXISTENCE:direct assay:GO:0005975 carbohydrate metabolic process [PMID:1425702]" /experiment="EXISTENCE:direct assay:GO:0005992 trehalose biosynthetic process [PMID:1425702]" /experiment="EXISTENCE:mutant phenotype:GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [PMID:1425702|PMID:9837904]" /experiment="EXISTENCE:mutant phenotype:GO:0004805 trehalose-phosphatase activity [PMID:9837904]" /experiment="EXISTENCE:mutant phenotype:GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [PMID:1425702]" /experiment="EXISTENCE:mutant phenotype:GO:0005975 carbohydrate metabolic process [PMID:1425702]" /experiment="EXISTENCE:mutant phenotype:GO:0005992 trehalose biosynthetic process [PMID:1425702]" /experiment="EXISTENCE:mutant phenotype:GO:0071465 cellular response to desiccation [PMID:25456447]" /experiment="EXISTENCE:physical interaction:GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [PMID:9837904]" /note="Synthase subunit of trehalose-6-P synthase/phosphatase complex; synthesizes the storage carbohydrate trehalose, which is critically important for survival of long-term desiccation; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid; required for pseudohyphal growth" /db_xref="GeneID:852423" /db_xref="SGD:S000000330" ORIGIN 1 mttdnakaql tsssggniiv vsnrlpvtit knsstgqyey amssgglvta leglkktytf 61 kwfgwpglei pddekdqvrk dllekfnavp iflsdeiadl hyngfsnsil wplfhyhpge 121 infdenawla yneanqtftn eiaktmnhnd liwvhdyhlm lvpemlrvki hekqlqnvkv 181 gwflhtpfps seiyrilpvr qeilkgvlsc dlvgfhtydy arhflssvqr vlnvntlpng 241 veyqgrfvnv gafpigidvd kftdglkkes vqkriqqlke tfkgckiivg vdrldyikgv 301 pqklhamevf lnehpewrgk vvlvqvavps rgdveeyqyl rsvvnelvgr ingqfgtvef 361 vpihfmhksi pfeelislya vsdvclvsst rdgmnlvsye yiacqeekkg slilseftga 421 aqslngaiiv npwntddlsd ainealtlpd vkkevnwekl ykyiskytsa fwgenfvhel 481 ystsssstss satkn // LOCUS NP_001257669 68 aa linear PLN 30-JUN-2025 DEFINITION Meo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257669 VERSION NP_001257669.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270740.1 REFERENCE 1 (residues 1 to 68) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 68) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 68) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 68) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35095. Method: conceptual translation. FEATURES Location/Qualifiers source 1..68 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..68 /product="Meo1p" /calculated_mol_wt="7628" CDS 1..68 /gene="MEO1" /locus_tag="YBR126W-A" /coded_by="NM_001270740.1:1..207" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; identified by gene-trapping, microarray analysis, and genome-wide homology searches; mRNA identified as translated by ribosome profiling data; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; partially overlaps the dubious ORF YBR126W-B" /db_xref="GeneID:13393614" /db_xref="SGD:S000028600" ORIGIN 1 maitpdkqkk eqqhqpqngp ldyahickci amffvvagvv lmffetgldp eqkeqikrlh 61 qldgipha // LOCUS NP_009685 517 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V1 sector ATPase subunit B [Saccharomyces cerevisiae S288C]. ACCESSION NP_009685 VERSION NP_009685.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178475.3 REFERENCE 1 (residues 1 to 517) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 517) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 517) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 517) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07244. On Jul 30, 2012 this sequence version replaced NP_009685.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..517 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..517 /product="H(+)-transporting V1 sector ATPase subunit B" /calculated_mol_wt="57618" Region 27..485 /region_name="V-ATPase_V1_B" /note="V-type (H+)-ATPase V1, B subunit; TIGR01040" /db_xref="CDD:273410" CDS 1..517 /gene="VMA2" /locus_tag="YBR127C" /gene_synonym="VAT2" /coded_by="NM_001178475.3:1..1554" /experiment="EXISTENCE:direct assay:GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain [PMID:2857169|PMID:2478556]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:26928762|PMID:18048916]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:31332264]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:10991947]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:18048916|PMID:2141385]" /experiment="EXISTENCE:mutant phenotype:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:2141385]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:2141385]" /experiment="EXISTENCE:mutant phenotype:GO:1902906 proteasome storage granule assembly [PMID:23690178]" /note="Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase; electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm; protein abundance increases in response to DNA replication stress; human homolog ATP6V1B1, implicated in autosomal-recessive distal renal tubular acidosis (RTA) with sensorineural deafness, complements yeast null mutant" /db_xref="GeneID:852424" /db_xref="SGD:S000000331" ORIGIN 1 mvlsdkelfa inkkaveqgf nvkprlnynt vsgvngplvi lekvkfpryn eivnltlpdg 61 tvrqgqvlei rgdraivqvf egtsgidvkk ttveftgesl ripvsedmlg rifdgsgrpi 121 dngpkvfaed yldingspin pyariypeem istgvsaidt mnsiargqki pifsasglph 181 neiaaqicrq aglvrptkdv hdgheenfsi vfaamgvnle tarffkqdfe engslertsl 241 flnlandpti eriitprlal ttaeylayqt erhvltiltd mssyadalre vsaareevpg 301 rrgypgymyt dlstiyerag rvegrngsit qipiltmpnd dithpipdlt gyitegqifv 361 drqlhnkgiy ppinvlpsls rlmksaigeg mtrkdhgdvs nqlyakyaig kdaaamkavv 421 geealsiedk lsleflekfe ktfitqgaye drtvfesldq awsllriypk emlnrispki 481 ldefydrard dadedeedpd trssgkkkda sqeesli // LOCUS NP_009686 344 aa linear PLN 30-JUN-2025 DEFINITION Atg14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009686 VERSION NP_009686.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178476.1 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 344) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07245. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..344 /product="Atg14p" /calculated_mol_wt="40323" Region 3..>224 /region_name="ATG14" /note="Vacuolar sorting 38 and autophagy-related subunit 14; pfam10186" /db_xref="CDD:462986" CDS 1..344 /gene="ATG14" /locus_tag="YBR128C" /gene_synonym="APG14; CVT12" /coded_by="NM_001178476.1:1..1035" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:16421251]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:23129774|PMID:16421251]" /experiment="EXISTENCE:direct assay:GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I [PMID:11157979]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:9712845]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:21121900]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:9712845|PMID:32788210|PMID:11157979]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:8901576]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0051365 cellular response to potassium ion starvation [PMID:32788210]" /note="Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I; Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor; other members are Vps34, Vps15, and Vps30p" /db_xref="GeneID:852425" /db_xref="SGD:S000000332" ORIGIN 1 mhcpichhra hvvycahcin tspslllklk ldlillkden kelngkveqi lneamnydql 61 dikrmekkkd plmnslmkld vlrmkknnnl irhrieqlne riyskrnhis elkveidnyk 121 cykvgtgtdk lreqveisda knklaqvski cesardykln llnnwfviqk lqdnfqipfa 181 iafqplislk nfrilplait ndsinimwky isffsdilmi klpytnkice qpmfefsdsi 241 qtvvqrlikl iinilqicrh lklvpstpmd ipwlldqydv dglfynmvkr nkmkcrsvsl 301 ywtfgmlysm vldnmnnpqr ghparrtapp ptvtgphdrw yvvg // LOCUS NP_009687 328 aa linear PLN 30-JUN-2025 DEFINITION Opy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009687 VERSION NP_009687.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178477.1 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 328) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07246. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..328 /product="Opy1p" /calculated_mol_wt="37609" Region <72..148 /region_name="PH-like" /note="Pleckstrin homology-like domain; cl17171" /db_xref="CDD:473070" Region 214..315 /region_name="PH-like" /note="Pleckstrin homology-like domain; cl17171" /db_xref="CDD:473070" CDS 1..328 /gene="OPY1" /locus_tag="YBR129C" /coded_by="NM_001178477.1:1..987" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:22562153]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22562153]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22562153]" /experiment="EXISTENCE:genetic interaction:GO:1902647 negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [PMID:22562153]" /experiment="EXISTENCE:mutant phenotype:GO:1902647 negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process [PMID:22562153]" /note="hypothetical protein; overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:852426" /db_xref="SGD:S000000333" ORIGIN 1 miagatapss qheiliasnl ikkpstsqnk tptaqsssgn ngaadgapqg yhhhhhhhrh 61 lwwprttdhq ywcvlrknqf ayyktrdere aisviprfdi lnfkiseldg iltvytpskd 121 lifkfprgqn ekvgmelmhn wkialekfls spsgnesvtt gsdydeeedd ddlivvdeka 181 gpssskhscs ltmdeqlsre dkefyrmfdp rnaehqvcsg ilytkvkkkk lfnrakwqkf 241 nveltntsfn lysfktgklk ksikldkiid cieldnnskm knddtnfali tfderlsfka 301 andqdmvdwi infksgilir kklkaeni // LOCUS NP_009688 425 aa linear PLN 30-JUN-2025 DEFINITION She3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009688 VERSION NP_009688.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178478.3 REFERENCE 1 (residues 1 to 425) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 425) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 425) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 425) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07247. On Jul 30, 2012 this sequence version replaced NP_009688.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..425 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..425 /product="She3p" /calculated_mol_wt="47286" Region 42..268 /region_name="SHE3" /note="SWI5-dependent HO expression protein 3; pfam17078" /db_xref="CDD:293683" CDS 1..425 /gene="SHE3" /locus_tag="YBR130C" /coded_by="NM_001178478.3:1..1278" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:10212145]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11032818]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:28092367]" /experiment="EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:8625407]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:10212145|PMID:28092367]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:14691136]" /note="Protein adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance" /db_xref="GeneID:852427" /db_xref="SGD:S000000334" ORIGIN 1 msdqdntqts ssklaphhni fmanlesspt kdrntssqna sssrvieslh dqidmltktn 61 lqlttqsqnl lsklelaqsk eskllenlnl lknenenlns iferknkklk elekdysels 121 nryneqkekm dqlsklakns saieqscsek lqnmevnyns llesqnlyrd hysdeiskln 181 ekigllelel snqnlnygsd tssnsdieln lnkfndsvkd lksletekds klskiithsl 241 delnlqswln lyqtnenlis tfaekmdlkd vlkrndekis nkgavvqtlk knvqtqvesn 301 nadalssnna qdmlpikmvk lrktpntnds ssngnssnnk rrsfytaspl lssgsipksa 361 spvlpgvkrt asvrkpssss sktnvthnnd pstsptisvp pgvtrtvsst hkkkgnsmvv 421 hgaqs // LOCUS NP_009689 704 aa linear PLN 30-JUN-2025 DEFINITION Ccz1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009689 VERSION NP_009689.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178479.3 REFERENCE 1 (residues 1 to 704) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 704) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 704) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 704) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07248. On Jul 30, 2012 this sequence version replaced NP_009689.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..704 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..704 /product="Ccz1p" /calculated_mol_wt="80602" Region 3..124 /region_name="Intu_longin_1" /note="First Longin domain of INTU, CCZ1 and HPS4; pfam19031" /db_xref="CDD:436911" CDS 1..704 /gene="CCZ1" /locus_tag="YBR131W" /gene_synonym="CVT16" /coded_by="NM_001178479.3:1..2115" /experiment="EXISTENCE:direct assay:GO:0001786 phosphatidylserine binding [PMID:24413168]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:20797862|PMID:24413168]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:20797862]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:11069774]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006914 autophagy [PMID:12208507]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:24413168]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:24413168]" /experiment="EXISTENCE:direct assay:GO:0035658 Mon1-Ccz1 complex [PMID:24413168]" /experiment="EXISTENCE:direct assay:GO:0097352 autophagosome maturation [PMID:12208507]" /experiment="EXISTENCE:genetic interaction:GO:0044395 protein targeting to vacuolar membrane [PMID:23979137]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12364329]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:11590240]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0044395 protein targeting to vacuolar membrane [PMID:23979137]" /experiment="EXISTENCE:mutant phenotype:GO:0048278 vesicle docking [PMID:14662743]" /experiment="EXISTENCE:physical interaction:GO:0035658 Mon1-Ccz1 complex [PMID:20797862]" /note="Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy" /db_xref="GeneID:852428" /db_xref="SGD:S000000335" ORIGIN 1 mrlhyitvfd psrstnendt fkqlllfhyf gttdsipsln eklsiigviq giwsltsscv 61 nkdgedleki ielnndiifc ikvesrffis laisnisddq saiplqylsa ylwlsyrffk 121 llngsfsgfn kdfrkltdll nefvipfwnd iylnletvtn rsftvmwpgf ykranfqhss 181 ynpgeknnve eswdaiilqn illdkksylg lkdilvyhlp krtkaanres mgtktyglvr 241 nftsdlntlp disnwlyhlh ctygeisshi ltgnvhfkee lqveeeqers rdtngrdeee 301 sqeqqrrehq ettqnntsel slservihnv tlpisfayda ihevstttgv sgslsmimdy 361 vpkphwpfis ssnksadknn ysnsndnans naplmaqsea vggtignsrf gflisplnsd 421 llpssyqalk lnlnfenskd kedfynclfw yfddfliviv cdpdfnkice rdylkdlsfq 481 lcqsmeclnn eilnsqncdn vesfayvird nvtkeidssv pfgspkftsd esistlqlai 541 ngidqfindn snslslanwn pitimggsna iskknttegf gngvndktqk fkrkylnfln 601 lmsaeklwdl qvdvlqflts lqnskrdpdy fqeerllkln ngvlcyiken nsnliiiikn 661 wfqnngtska akqrnrfssd sskgsslfqs lgrdvtdwwe srei // LOCUS NP_009690 596 aa linear PLN 30-JUN-2025 DEFINITION Agp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009690 VERSION NP_009690.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178480.1 REFERENCE 1 (residues 1 to 596) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 596) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 596) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 596) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07249. Method: conceptual translation. FEATURES Location/Qualifiers source 1..596 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..596 /product="Agp2p" /calculated_mol_wt="67131" Region 92..563 /region_name="AA_permease" /note="Amino acid permease; pfam00324" /db_xref="CDD:366028" CDS 1..596 /gene="AGP2" /locus_tag="YBR132C" /coded_by="NM_001178480.1:1..1791" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:10545096]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10545096]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10545096]" /experiment="EXISTENCE:mutant phenotype:GO:1902269 positive regulation of polyamine transmembrane transport [PMID:23755272]" /experiment="EXISTENCE:mutant phenotype:GO:1902274 positive regulation of (R)-carnitine transmembrane transport [PMID:23755272]" /note="Plasma membrane regulator of high affinity polyamine and carnitine transport; has similarity to transporters but lacks transport activity; may act as a sensor that transduces environmental signals; has a positive or negative regulatory effect on transcription of many transporter genes; null mutant is cycloheximide (CHX) resistant; ubiquitinated Agp2p is rapidly degraded in a Brp1p-dependent manner in the presence of CHX; localizes to the plasma membrane, the vacuolar membrane and the ER membrane" /db_xref="GeneID:852429" /db_xref="SGD:S000000336" ORIGIN 1 mtkermtidy endgdfeydk nkyktittri ksiepsegwl epsgsvghin tipeagdvhv 61 dehedrgssi dddsrtylly ftetrrklen rhvqliaisg vigtalfvai gkalyrggpa 121 slllafalwc vpilcitvst aemvcffpvs spflrlatkc vddslavmas wnfwflecvq 181 ipfeivsvnt iihywrddys agiplavqvv lyllisicav kyygemefwl asfkiilalg 241 lftftfitml ggnpehdryg frnygespfk kyfpdgndvg kssgyfqgfl acliqasfti 301 aggeyismla gevkrprkvl pkafkqvfvr ltflflgscl cvgivcspnd pdltaainea 361 rpgagsspyv iamnnlkiri lpdivniali taafsagnay tycssrtfyg maldgyapki 421 ftrcnrhgvp iysvaislvw alvsllqlns nsavvlnwli nlitasqlin fvvlcivylf 481 frrayhvqqd slpklpfrsw gqpytaiigl vscsamiliq gytvffpklw ntqdflfsyl 541 mvfinigiyv gykfiwkrgk dhfknpheid fskelteien heiessfekf qyyska // LOCUS NP_009691 827 aa linear PLN 30-JUN-2025 DEFINITION protein arginine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009691 VERSION NP_009691.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178481.1 REFERENCE 1 (residues 1 to 827) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 827) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 827) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 827) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07250. Method: conceptual translation. FEATURES Location/Qualifiers source 1..827 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..827 /product="protein arginine N-methyltransferase" /EC_number="2.1.1.320" /calculated_mol_wt="95023" Region 38..308 /region_name="PRMT5_TIM" /note="PRMT5 TIM barrel domain; pfam17285" /db_xref="CDD:435840" Region 316..493 /region_name="PRMT5" /note="PRMT5 arginine-N-methyltransferase; pfam05185" /db_xref="CDD:428356" Region 496..690 /region_name="PRMT5_C" /note="PRMT5 oligomerization domain; pfam17286" /db_xref="CDD:435841" CDS 1..827 /gene="HSL7" /locus_tag="YBR133C" /coded_by="NM_001178481.1:1..2484" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:10490648|PMID:27053666]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:17898715|PMID:18515076]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:11408575]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:11408575|PMID:10805747]" /experiment="EXISTENCE:direct assay:GO:0008469 histone arginine N-methyltransferase activity [PMID:18515076]" /experiment="EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:23389636]" /experiment="EXISTENCE:direct assay:GO:0035241 protein-arginine omega-N monomethyltransferase activity [PMID:16426232|PMID:18515076]" /experiment="EXISTENCE:direct assay:GO:0035243 protein-arginine omega-N symmetric methyltransferase activity [PMID:18515076]" /experiment="EXISTENCE:direct assay:GO:0045815 transcription initiation-coupled chromatin remodeling [PMID:17898715]" /experiment="EXISTENCE:direct assay:GO:0160217 negative regulation of transcription initiation-coupled chromatin remodeling [PMID:17898715]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10490630]" /experiment="EXISTENCE:mutant phenotype:GO:0000144 cellular bud neck septin ring [PMID:27053666]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:23042131]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:8647431]" /note="Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent localization to the bud neck in budded cells and periodic Hsl1p-dependent phosphorylation; required with Hsl1p, and Elm1p for the mother-bud neck recruitment, phosphorylation, and degradation of Swe1p; responsible for symmetric dimethylation of histone H4 on Arg3; relocalizes away from bud neck upon DNA replication stress; human homolog PRMT5 can complement yeast hsl7 mutant" /db_xref="GeneID:852431" /db_xref="SGD:S000000337" ORIGIN 1 mhsnvfvgvk pgfnhkqhsk ksrflenvss hspelpsnyd yvllpittpr ykeivgqvfk 61 dfqrqsiqnw kplqipepql qdicippfnv kkldnddtps yigllsswle lesrdpnvrd 121 lglkvllnec kyarfvgink lilapprdls nlqlygqmiy rllqnrivfa apaltisisl 181 plyedsdpla twelwntvrk qceyhpslti slalprtrtp syvlnrwlae pvscllvsss 241 ifasnqydyp vlhkfnqnli lkfqkvngds qilgnelcvi lhgmekyann vkggesayle 301 yinyllkkgd kvlnsnsnhq fllqedsrim pplkphsdnl lnstyltfek dlvkydlyes 361 ailealqdla prasakrplv ilvagagrgp lvdrtfkiis mlfmdskvsi iaieknpqay 421 lylqkrnfdc wdnrvklike dmtkwqinep sekriqidlc isellgsfgc nelspeclws 481 iekyhshndt ifiprsyssy iapissplfy qklsqtnrsl eapwivhrvp ycilssrvne 541 vwrfehpmaq kdtvqdeddf tvefsqssln efkikhrgei hgfigffsan lynniflstl 601 pndstvrlkf seetlmntrr eenlikkcdh tpnmtswspi ifplkqpisf iddselsvlm 661 srihsdteqk vwyewslesf iylmlsnyts avtaasmtip rsivtddtkt lahnrhysat 721 tnqkldnqid ldqdieneee qgflsnletg wqsvqdihgl setakpdhld sinkpmfdlk 781 stkalepsne lprhedleed vpevhvrvkt svstlhnvcg rafslpl // LOCUS NP_009693 150 aa linear PLN 30-JUN-2025 DEFINITION cyclin-dependent protein kinase regulatory subunit CKS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009693 VERSION NP_009693.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178483.3 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 150) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07251. On Jul 30, 2012 this sequence version replaced NP_009693.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..150 /product="cyclin-dependent protein kinase regulatory subunit CKS1" /calculated_mol_wt="17664" Region 28..104 /region_name="CKS" /note="Cyclin-dependent kinase regulatory subunit; pfam01111" /db_xref="CDD:460068" CDS 1..150 /gene="CKS1" /locus_tag="YBR135W" /coded_by="NM_001178483.3:1..453" /experiment="EXISTENCE:direct assay:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:2664468]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:10913169]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:20855529]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:17198374]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20516216]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15629725]" /experiment="EXISTENCE:mutant phenotype:GO:0007346 regulation of mitotic cell cycle [PMID:8491379|PMID:2664468]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20516216]" /note="Cyclin-dependent protein kinase regulatory subunit and adaptor; interacts with Cdc28p (aka Cdk1p); required for G1/S and G2/M phase transitions and budding; mediates phosphorylation and degradation of Sic1p; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters; human homologs CKS1B and CKS2 can each complement yeast cks1 null mutant" /db_xref="GeneID:852432" /db_xref="SGD:S000000339" ORIGIN 1 myhhyhafqg rkltdqerar vlefqdsihy sprysddnye yrhvmlpkam lkvipsdyfn 61 sevgtlrilt edewrglgit qslgwehyec hapephillf krplnyeael raataaaqqq 121 qqqqqqqqqq qqqhqtqsis ndmqvppqis // LOCUS NP_009694 2368 aa linear PLN 30-JUN-2025 DEFINITION protein kinase MEC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009694 VERSION NP_009694.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178484.3 REFERENCE 1 (residues 1 to 2368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2368) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 2368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07252. On Jul 30, 2012 this sequence version replaced NP_009694.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..2368 /product="protein kinase MEC1" /EC_number="2.7.11.1" /calculated_mol_wt="273212" Region 194..2368 /region_name="TEL1" /note="Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032" /db_xref="CDD:227365" CDS 1..2368 /gene="MEC1" /locus_tag="YBR136W" /gene_synonym="ESR1; RAD31; SAD3" /coded_by="NM_001178484.3:1..7107" /experiment="EXISTENCE:direct assay:GO:0000723 telomere maintenance [PMID:15721260]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:11095737]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23934994]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:17202155]" /experiment="EXISTENCE:genetic interaction:GO:0004672 protein kinase activity [PMID:21841787]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:10511542]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:10511543]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511543]" /experiment="EXISTENCE:mutant phenotype:GO:0042770 signal transduction in response to DNA damage [PMID:17693258]" /experiment="EXISTENCE:mutant phenotype:GO:2000105 positive regulation of DNA-templated DNA replication [PMID:23307868]" /note="Genome integrity checkpoint protein and PI kinase superfamily member; Mec1p and Dun1p function in same pathway to regulate dNTP pools and telomere length; signal transducer required for cell cycle arrest and transcriptional responses to damaged or unreplicated DNA; facilitates replication fork progression and regulates P-body formation under replication stress; promotes interhomolog recombination by phosphorylating Hop1p; associates with shortened, dysfunctional telomeres" /db_xref="GeneID:852433" /db_xref="SGD:S000000340" ORIGIN 1 meshvkylde lilaikdlns gvdskvqikk vptdpsssqe yakslkilnt lirnlkdqrr 61 nnimkndtif sktvsalall leynpfllvm kdsngnfeiq rliddflnis vlnydnyhri 121 wfmrrklgsw ckacvefygk pakfqltahf entmnlyeqa ltevllgkte llkfydtlkg 181 lyillywfts eystfgnsia fldsslgftk fdfnfqrlir ivlyvfdsce laaleyaeiq 241 lkyislvvdy vcnrtistal dapalvcceq lkfvlttmhh fldnkyglld ndptmakgil 301 rlyslcisnd fskcfvdhfp idqwadfsqs ehfpftqltn kalsivyfdl krrslpveal 361 kydnkfniwv yqsepdsslk nvtspfddry kqleklrllv lkkfnkterg tllkyrvnql 421 spgffqragn dfklilneas vsiqtcfktn nitrltswtv ilgrlacles ekfsgtlpns 481 tkdmdnwyvc hlcdiektgn pfvrinpnrp eaagkseifr ilhsnflshp nidefsesll 541 sgilfslhri fshfqppklt dgngqinksf klvqkcfmns nrylrllstr iiplfnisds 601 hnsedehtat likflqsqkl pvvkenlvia wtqltlttsn dvfdtlllkl idifnsddys 661 lrimmtlqik nmakilkktp yqllspilpv llrqlgknlv erkvgfqnli ellgysskti 721 ldifqryiip yaiiqyksdv lseiakimcd gdtslinqmk vnllkknsrq ifavalvkhg 781 lfsldiletl flnraptfdk gyitaylpdy ktlaeitkly knsvtkdasd senanmilcs 841 lrflitnfek dkrhgskykn innwtddqeq afqkklqdni lgifqvfssd ihdvegrtty 901 yeklrvingi sfliiyapkk siisalaqis iclqtglglk evryeafrcw hllvrhlnde 961 elstvidsli afilqkwsef ngklrnivys ildtlikeks dlilklkpyt tlalvgkpel 1021 gilardgqfa rmvnkirstt dlipifannl kssnkyvinq nlddievylr rkqtersidf 1081 tpkkvgqtsd itlvlgalld tshkfrnldk dlcekcakci smigvldvtk hefkrttyse 1141 nevydlndsv qtikfliwvi ndilvpafwq senpskqlfv alviqeslky cglsseswdm 1201 nhkelypnea klwekfnsvs kttiypllss lylaqswkey vplkypsnnf kegykiwvkr 1261 ftldllktgt tenhplhvfs slireddgsl snfllpyisl diiikaekgt pyadilngii 1321 iefdsiftcn legmnnlqvd slrmcyesif rvfeyckkwa tefkqnyskl hgtfiikdtk 1381 ttnmllride flrttpsdll aqrsletdsf ersalyleqc yrqnphdknq ngqllknlqi 1441 tyeeigdids ldgvlrtfat gnlvskieel qysenwklaq dcfnvlgkfs ddpktttrml 1501 ksmydhqlys qiisnssfhs sdgkislspd vkewysigle aanlegnvqt lknwveqies 1561 lrniddrevl lqyniakali aisnedplrt qkyihnsfrl igtnfitssk ettllkkqnl 1621 lmklhslydl sflssakdkf eyksnttild yrmerigadf vpnhyilsmr ksfdqlkmne 1681 qadadlgktf ftlaqlarnn arldiasesl mhclerrlpq aelefaeilw kqgendralk 1741 ivqeihekyq enssvnardr aavllkftew ldlsnnsase qiikqyqdif qidskwdkpy 1801 ysiglyysrl lerkkaegyi tngrfeyrai syfllafekn takvrenlpk vitfwldiaa 1861 asiseapgnr kemlskated icshveealq hcptyiwyfv ltqllsrllh shqssaqiim 1921 hillslavey pshilwyita lvnsnsskrv lrgkhileky rqhsqnphdl vssaldltka 1981 ltrvclqdvk sitsrsgksl ekdfkfdmnv apsamvvpvr knldiisple snsmrgyqpf 2041 rpvvsiirfg ssykvfsslk kpkqlniigs dgniygimck kedvrqdnqy mqfattmdfl 2101 lskdiasrkr slginiysvl slredcgile mvpnvvtlrs ilstkyeslk ikyslkslhd 2161 rwqhtavdgk lefymeqvdk fppilyqwfl enfpdpinwf narntyarsy avmamvghil 2221 glgdrhceni lldiqtgkvl hvdfdclfek gkrlpvpeiv pfrltpnlld algiigtegt 2281 fkkssevtla lmrknevalm nvietimydr nmdhsiqkal kvlrnkirgi dpqdglvlsv 2341 agqtetliqe atsednlskm yigwlpfw // LOCUS NP_009695 179 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR137W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009695 VERSION NP_009695.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178485.2 REFERENCE 1 (residues 1 to 179) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 179) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 179) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 179) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07253. On Apr 26, 2011 this sequence version replaced NP_009695.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..179 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..179 /product="uncharacterized protein" /calculated_mol_wt="20323" Region 19..174 /region_name="COG4702" /note="Uncharacterized conserved protein, UPF0303 family [Function unknown]" /db_xref="CDD:443737" CDS 1..179 /locus_tag="YBR137W" /coded_by="NM_001178485.2:1..540" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11266464]" /experiment="EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]" /experiment="EXISTENCE:genetic interaction:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:25288638]" /note="Protein with a role in ER delivery of tail-anchored membrane proteins; interacts with Sgt2p; binds to the TRC complex, which inserts proteins into the ER membrane; interacts with Msn5p karyopherin; YBR137W is not an essential gene" /db_xref="GeneID:852434" /db_xref="SGD:S000000341" ORIGIN 1 mvvldkklle rltsrkvple eledmekrcf lstftyqdaf dlgtyirnav kenfpekpva 61 idislpnghc lfrtvtyggs aldndfwiqr kkktalrfgh ssfymgckkg dktpeekffv 121 dskeyafhgg avliqsersd ypyacltisg lkqeedhlma vssliafane sleedlnld // LOCUS NP_009696 524 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR138C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009696 VERSION NP_009696.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178486.2 REFERENCE 1 (residues 1 to 524) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 524) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 524) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 524) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07254. On Apr 26, 2011 this sequence version replaced NP_009696.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..524 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..524 /product="uncharacterized protein" /calculated_mol_wt="60338" CDS 1..524 /locus_tag="YBR138C" /coded_by="NM_001178486.2:1..1575" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic hypothetical protein; APCC(Cdh1) substrate; potentially phosphorylated by Cdc28p; YBR138C is not an essential gene" /db_xref="GeneID:852435" /db_xref="SGD:S000000342" ORIGIN 1 mekdqiqprv lesvdtnsls llssntssnm nsntnnklsi iasdistgsv lsrpltppvv 61 qdiennsmlq wqfekkefif dsnstpskqa kplqrnspyq gnsqsenqnq qllnvrkrrs 121 qligakpkip sklyqsvskl dliddksfts lpiappcnie tneddsgnne ynnnkkrprl 181 npvnelrvhn nkrnryvsyg psldtknyel tentsqdipp lvlvedyipy tqskstkkmv 241 sisdlkskls krrdnhiplr vknsyseink etnrnsfepn sltliphilr nteenrdesn 301 npldfikeei eisdisipns ienmvvnlvn ipssnksydd lylselnvhs qlrkcvicek 361 alyeissrll nsgyykeivc eqctvryeea akifencefe ssmdesnlss gtfsdlensa 421 epfhlstdvp kkinrhiedn kidlkkeisk kkdsfskeli erlqlqllen dksikhhfnk 481 damgsksmnw flearrklkw kwringllph flrnqnsdrl nfqp // LOCUS NP_009697 508 aa linear PLN 30-JUN-2025 DEFINITION carboxypeptidase C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009697 VERSION NP_009697.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178487.3 REFERENCE 1 (residues 1 to 508) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 508) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 508) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 508) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07255. On Jul 30, 2012 this sequence version replaced NP_009697.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..508 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..508 /product="carboxypeptidase C" /EC_number="3.4.16.5" /calculated_mol_wt="57508" Region 83..494 /region_name="Peptidase_S10" /note="Serine carboxypeptidase; pfam00450" /db_xref="CDD:459815" CDS 1..508 /gene="ATG42" /locus_tag="YBR139W" /coded_by="NM_001178487.3:1..1527" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:29514932]" /experiment="EXISTENCE:direct assay:GO:0017171 serine hydrolase activity [PMID:14645503]" /experiment="EXISTENCE:genetic interaction:GO:0004185 serine-type carboxypeptidase activity [PMID:29514932]" /experiment="EXISTENCE:genetic interaction:GO:0005775 vacuolar lumen [PMID:29514932]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:29514932]" /experiment="EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:29514932]" /experiment="EXISTENCE:genetic interaction:GO:0031638 zymogen activation [PMID:29514932]" /experiment="EXISTENCE:genetic interaction:GO:0046938 phytochelatin biosynthetic process [PMID:17408619]" /note="Vacuolar serine-type carboxypeptidase; involved, along with functional homolog Prc1p, in vacuolar zymogen activation, breakdown of the autophagic body, and autophagosome-dependent protein synthesis; role in phytochelatin synthesis; localizes to the vacuole lumen; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner; N-glycosylated" /db_xref="GeneID:852436" /db_xref="SGD:S000000343" ORIGIN 1 mkylnlvfvl qllisikyas fgrafslfed dttfanldkq lklpqntqqt lkldrlnhdd 61 plfttfissv dtdyslrlrt vdpsklgidt vkqwsgymdy kdskhffywf fesrndpand 121 piilwlnggp gcssftgllf elgpssigad mkpihnpysw nnnasmifle qplgvgfsyg 181 dekvsstkla gkdayiflel ffeafphlrs ndfhiagesy aghyipqiah eivvknpert 241 fnltsvmign gitdpliqad yyepmacgkg gyhpvlssee cekmskaagr crrlnklcya 301 sksslpciva taycdsalle pyintglnvy dirgpcedns tdgmcytglr yvdqymnfpe 361 vqetlgsdvh nysgcdndvf tgflftgdgs kpfqqyiael lnhnipvliy agdkdyicnw 421 lgnhawsnel ewinkrryqr rmlrpwvske tgeelgqvkn ygpftflriy daghmvpydq 481 peaslemvns wisgnrafsd lstlenas // LOCUS NP_009698 3092 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein IRA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009698 VERSION NP_009698.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178488.3 REFERENCE 1 (residues 1 to 3092) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 3092) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 3092) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 3092) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 3092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 3092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 3092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07256. On Jul 30, 2012 this sequence version replaced NP_009698.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..3092 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..3092 /product="GTPase-activating protein IRA1" /calculated_mol_wt="350851" Region 1679..1995 /region_name="RasGAP_Neurofibromin_like" /note="Ras-GTPase Activating Domain of proteins similar to neurofibromin; cd05392" /db_xref="CDD:213341" Site order(1710,1746,1748,1750..1751,1753,1756,1760,1851, 1859..1860,1863..1864,1867,1887,1890..1891,1894,1898,1900, 1905..1906) /site_type="other" /note="putative RAS interface [polypeptide binding]" /db_xref="CDD:213341" CDS 1..3092 /gene="IRA1" /locus_tag="YBR140C" /gene_synonym="GLC1; PPD1" /coded_by="NM_001178488.3:1..9279" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:2178777]" /experiment="EXISTENCE:mutant phenotype:GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [PMID:2540426]" /experiment="EXISTENCE:mutant phenotype:GO:0016020 membrane [PMID:1875942]" /experiment="EXISTENCE:mutant phenotype:GO:0046580 negative regulation of Ras protein signal transduction [PMID:15339905]" /note="GTPase-activating protein; negatively regulates RAS by converting it from GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase; mutations cause catalase T deficiency, defective glycogen synthesis and defective trehalose accumulation; IRA1 has a paralog, IRA2, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis" /db_xref="GeneID:852437" /db_xref="SGD:S000000344" ORIGIN 1 mnqsdpqdkk nfpmeysltk hlffdrlllv lpiesnlkty adveadsvfn scrsiilnia 61 itkdlnpiie ntlglidliv qdeeitsdni tddiahsilv llrllsdvfe yywdqnndfk 121 kirndnykpg fsshrpnfht srpkhtrinp alatmllcki sklkfntrtl kvlqnmshhl 181 sgsatiskss ilpdsqeflq krnypaytek idltidyiqr fisasnhvef tkcvktkvva 241 pllishtste lgvvnhldlf gceyltdknl layldilqhl ssymkrtifh slllyyaska 301 flfwimarpk eyvkiynnli ssdynspsss sdnggsnnsd ktsisqlvsl lfddvystfs 361 vsslltnvnn dhhyhlhhss ssskttntns pnsisktsik qssvnasgnv spsqfstgnd 421 asptspmasl ssplntnilg yplspitstl gqantststt aattktdadt pstmntnnnn 481 nnnnsanlnn ipqrifsldd issfnssrks lnlddsnslf lwdtsqhsna smtntnmhag 541 vnnsqsqndq sslnymenim elysnytgse lsshtailrf lvvltlldse vydemnsnsy 601 rkisepimni npkdsntssw gsasknpsir hlthglkklt lqqgrkrnvk fltylirnln 661 ggqfvsdvsl idsirsilfl mtmtssisqi dsniasvifs krfynllgqn levgtnwnsa 721 tantfishcv ernplthrrl qleffasglq ldsdlflrhl qlekelnhid lpkislyteg 781 frvffhlvst kklhediaek tssvlkrlfc iiadillkat pyfddnvtki iasildghil 841 dqfdaartls nddhvsfdaa tsvyteptei ihnssdaslv sslsqsplsi nsgsnitntr 901 twdiqsilpt lsnrssasdl slsniltnpl eaqqnnnanl lahrlsgvpt tkryaspnds 961 ersrqspyss ppqlqqsdlp splsvlsssa gfssnhsita tptilkniks pkpnktkkia 1021 ddkqlkqpsy srvilsdnde arkimmnifs ifkrmtnwfi rpdantefpk tftdiikplf 1081 vsildsnqrl qvtarafiei plsyiatfed idndldprvl ndhyllctya vtlfasslfd 1141 lklenakrem lldiivkfqr vrsylsnlae khnlvqaiit terltlpllv gavgsgifis 1201 lycsrgntpr likisccefl rslrfyqkyv galdqysiyn idfidamaqd nftasgsval 1261 qrrlrnnilt yikgsdsill dsmdviykkw fyfscsksvt qeelvdfrsl agilasmsgi 1321 lsdmqeleks ksapdnegds lsfesrnpay evhkslklel tkkmnffisk qcqwlnnpnl 1381 ltrensrdil sielhplsfn llfnnlglki delmsidlsk shedssfvll eqiiiiirti 1441 lkrdddekim llfstdllda vdklieivek isiksskyyk giiqmskmfr afehseknlg 1501 isnhfhlknk wlklvigwfk lsinkdydfe nlsrplremd lqkrdedfly idtsiesaka 1561 laylthnvpl eippsssked wnrsstvsfg nhftillkgl eksadlnqfp vslrhkisil 1621 nenviialtn lsnanvnvsl kftlpmgysp nkdiriaflr vfidivtnyp vnpekhemdk 1681 mlaiddflky iiknpilaff gslacspadv dlyaggflna fdtrnashil vtellkqeik 1741 raarsddilr rnscatrals lytrsrgnky liktlrpvlq givdnkesfe idkmkpgsen 1801 sekmldlfek ymtrlidait ssiddfpiel vdicktiyna asvnfpeyay iavgsfvflr 1861 figpalvspd seniiivtha hdrkpfitla kviqslangr enifkkdilv skeeflktcs 1921 dkifnflsel ckiptnnftv nvredptpis fdysflhkff ylneftirke iinesklpge 1981 fsflkntvml ndkilgvlgq psmeikneip pfvvenreky pslyefmsry afkkvdmkee 2041 eednapfvhe amtldgiqii vvtftnceyn nfvmdslvyk vlqiyarmwc skhyvvidct 2101 tfyggkanfq klttlffsli peqassncmg cyyfnvnksf mdqwassytv enpylvttip 2161 rcfinsntdq slikslglsg rslevlkdvr vtlhditlyd kekkkfcpvs lkignkyfqv 2221 lheipqlykv tvsnrtfsik fnnvykisnl isvdvsnttg vsseftlsld neeklvfcsp 2281 kyleivkmfy yaqlkmeedf gtdfsndisf stsssavnas ycnvkevgei ishlslvilv 2341 glfneddlvk nisynllvat qeafnldfgt rlhkspetyv pddtttflal ifkafsesst 2401 eltpyiwkym ldglendvip qehiptvvcs lsywvpnlye hvylandeeg peaisriiys 2461 lirltvkepn fttaylqqiw fllaldgrlt nviveeivsh aldrdsenrd wmkavsilts 2521 fptteiacqv ieklinmiks flpslaveas ahswseltil skisvsiffe spllsqmylp 2581 eilfavslli dvgpseirvs lyellmnvch sltnneslpe rnrknldivc atfarqklnf 2641 isgfsqekgr vlpnfaassf sskfgtldlf tknimllmey gsisegaqwe akykkylmda 2701 ifghrsffsa rammilgims kshtslflck ellvetmkvf aepvvddeqm fiiiahvfty 2761 skivegldps selmkelfwl aticvesphp llfeggllfm vnclkrlytv hlqlgfdgks 2821 lakklmesrn faatllakle syngciwned nfphiilgfi anglsipvvk gaaldclqal 2881 fkntyyerks npkssdylcy lfllhlvlsp eqlstlllev gfedelvpln ntlkvpltli 2941 nwlssdsdks nivlyqgall fscvmsdepc kfrfallmry llkvnpicvf rfytltrkef 3001 rrlstleqss eavavsfeli gmlvthsefn yleefndemv ellkkrglsv vkpldifdqe 3061 hieklkgege hqvaiyerkr latmilarms cs // LOCUS NP_009699 337 aa linear PLN 30-JUN-2025 DEFINITION 25S rRNA (adenine2142-N1)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009699 VERSION NP_009699.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178489.2 REFERENCE 1 (residues 1 to 337) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 337) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 337) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 337) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07257. On Apr 26, 2011 this sequence version replaced NP_009699.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..337 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..337 /product="25S rRNA (adenine2142-N1)-methyltransferase" /EC_number="2.1.1.286" /calculated_mol_wt="38419" Region 125..335 /region_name="Bmt2" /note="25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2; pfam11968" /db_xref="CDD:371825" CDS 1..337 /gene="BMT2" /locus_tag="YBR141C" /coded_by="NM_001178489.2:1..1014" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:23558746|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:35139378]" /experiment="EXISTENCE:mutant phenotype:GO:0016433 rRNA (adenine) methyltransferase activity [PMID:23558746]" /note="Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of large subunit (LSU) rRNA at position 2142; belongs to Rossmann fold superfamily; null mutant exhibits abnormal lipid metabolic phenotype; not an essential gene" /db_xref="GeneID:852438" /db_xref="SGD:S000000345" ORIGIN 1 mhsrksksit gkrkqvgsnv trvikpqktr riirrfhhli nkrqsickfl clkenlddsn 61 eekndkiirl sikgnvrlgk yyedgksqsf ndamesqllr lhsliknesk skdtsdlavm 121 ytllgyimnq inklgglety qiasqngqlk erggdtskll ekwirssfen cpgavaleig 181 slssgnrisr calfrnvvri dleehegvik qdfmerplpr nendkfdlis cslvlnfvkn 241 hrdrgamchr mvkflkpqgy ifivlpqacv thsrycdktl lqnllgsigl imlnshqsnk 301 lyyclyqlqv vppqpssfsk rikvndgpgl nnfgitl // LOCUS NP_009700 773 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009700 VERSION NP_009700.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178490.1 REFERENCE 1 (residues 1 to 773) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 773) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 773) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 773) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 773) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 773) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 773) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07258. Method: conceptual translation. FEATURES Location/Qualifiers source 1..773 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..773 /product="ATP-dependent RNA helicase" /EC_number="3.6.4.13" /calculated_mol_wt="86917" Region 178..643 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..773 /gene="MAK5" /locus_tag="YBR142W" /coded_by="NM_001178490.1:1..2322" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:13680366]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:13680366]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:13680366]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:7739558|PMID:13680366]" /note="Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits" /db_xref="GeneID:852439" /db_xref="SGD:S000000346" ORIGIN 1 mgkkrapqkg ktvtkpqeii vdesklnwkp vdipdtlddf ggfygleeid gvdvkvvdgk 61 vtfvtkkdsk vlkdsnkekv gddqesvene sgsdsesell efknlddike gelsaasyss 121 sdedeqgnie sskltdpsed vdedvdedvl kenvfnkdin iddispvnlp ewtnlaplsm 181 tilqslqnln flrpteiqkk sipvimqgvd vmgkastgsg ktlaygipiv eklisnfsqk 241 nkkpislift ptrelahqvt dhlkkicepv laksqysils ltgglsiqkq qrllkydnsg 301 qiviatpgrf lellekdntl ikrfskvntl ildeadrllq dghfdefeki ikhllverrk 361 nrensegssk iwqtlifsat fsidlfdkls ssrqvkdrrf knnedelnav iqhlmskihf 421 nskpviidtn peskvssqik esliecpple rdlycyyflt mfpgttlifc naidsvkklt 481 vylnnlgipa fqihssmtqk nrlkslerfk qqsakqktin hsnpdsvqls tvliasdvaa 541 rgldipgvqh vihyhlprst diyihrsgrt aragsegvsa micspqesmg plrklrktla 601 tknsvstdln srstnrkpik wqntvpllpi etdilsqlre rsrlagelad heiasnslrk 661 ddnwlkkaad elgidvdsde ddisksnsdt fllknknkkm qktinkdkvk amratlnell 721 svpirkdrrq kyltgglvnl adnlvkkrgh nsiighektn aletlkkkkk rnn // LOCUS NP_009701 437 aa linear PLN 30-JUN-2025 DEFINITION translation termination factor eRF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009701 VERSION NP_009701.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178491.3 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 437) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07259. On Jul 30, 2012 this sequence version replaced NP_009701.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..437 /product="translation termination factor eRF1" /calculated_mol_wt="48875" Region 10..412 /region_name="aRF1/eRF1" /note="peptide chain release factor 1, archaeal and eukaryotic forms; TIGR03676" /db_xref="CDD:274719" CDS 1..437 /gene="SUP45" /locus_tag="YBR143C" /gene_synonym="SAL4; SUP1; SUP47" /coded_by="NM_001178491.3:1..1314" /experiment="EXISTENCE:direct assay:GO:0003747 translation release factor activity [PMID:20947765]" /experiment="EXISTENCE:direct assay:GO:0006415 translational termination [PMID:20947765]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23451152]" /experiment="EXISTENCE:direct assay:GO:0018444 translation release factor complex [PMID:7556078]" /experiment="EXISTENCE:genetic interaction:GO:0006415 translational termination [PMID:18724935]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:9182990|PMID:18724935]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0016149 translation release factor activity, codon specific [PMID:9182990]" /note="Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p" /db_xref="GeneID:852440" /db_xref="SGD:S000000347" ORIGIN 1 mdneveknie iwkvkklvqs lekargngts mislvippkg qiplyqkmlt deygtasnik 61 srvnrlsvls aitstqqklk lyntlpkngl vlycgdiite dgkekkvtfd iepykpints 121 lylcdnkfht evlsellqad dkfgfivmdg qgtlfgsvsg ntrtvlhkft vdlpkkhgrg 181 gqsalrfarl reekrhnyvr kvaevavqnf itndkvnvkg lilagsadfk tdlakselfd 241 prlackvisi vdvsyggeng fnqaielsae alanvkyvqe kklleayfde isqdtgkfcy 301 giddtlkald lgaveklivf enletirytf kdaednevik faepeakdks faidkatgqe 361 mdvvseepli ewlaanyknf gatlefitdk ssegaqfvtg fggigamlry kvnfeqlvde 421 sedeyydede gsdydfi // LOCUS NP_001335745 104 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR144C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335745 VERSION NP_001335745.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348890.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 104) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80265. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..104 /product="uncharacterized protein" /calculated_mol_wt="12187" CDS 1..104 /locus_tag="YBR144C" /coded_by="NM_001348890.1:1..315" /note="hypothetical protein; conserved across S. cerevisiae strains; YBR144C is not an essential gene" /db_xref="GeneID:852441" /db_xref="SGD:S000000348" ORIGIN 1 mlfdssfrer rtfynaagsv svpfykqiae qthdifkrcn vrehilrpcp vdishfsrdl 61 ngaplsyten ikftakfwan awidyesvmk tllvklyisf ffmc // LOCUS NP_009703 351 aa linear PLN 30-JUN-2025 DEFINITION alcohol dehydrogenase ADH5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009703 VERSION NP_009703.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178493.3 REFERENCE 1 (residues 1 to 351) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 351) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 351) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 351) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07260. On Jul 30, 2012 this sequence version replaced NP_009703.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..351 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..351 /product="alcohol dehydrogenase ADH5" /EC_number="1.1.1.1" /calculated_mol_wt="37517" Region 10..347 /region_name="CAD3" /note="Cinnamyl alcohol dehydrogenases (CAD); cd08297" /db_xref="CDD:176257" Site order(47..49,52,157,161,181,183..184,186,204..205,210, 249..252,255,272..274,297..299,344) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:176257" Site order(47,49,58,70,96,157,274,299) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:176257" Site order(47,70,157) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176257" Site order(58,103,105..106,114..116,172..174,196..198,200,212, 215..216,256,264,266,271,273..274,284..285,290..298, 302..303,307,311,314) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:176257" Site order(101,104,107,115) /site_type="other" /note="structural Zn binding site [ion binding]" /db_xref="CDD:176257" CDS 1..351 /gene="ADH5" /locus_tag="YBR145W" /coded_by="NM_001178493.3:1..1056" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /experiment="EXISTENCE:mutant phenotype:GO:0019655 glycolytic fermentation to ethanol [PMID:15082781]" /note="Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication" /db_xref="GeneID:852442" /db_xref="SGD:S000000349" ORIGIN 1 mpsqvipekq kaivfyetdg kleykdvtvp epkpneilvh vkysgvchsd lhawhgdwpf 61 qlkfpliggh egagvvvklg snvkgwkvgd fagikwlngt cmsceycevg nesqcpyldg 121 tgfthdgtfq eyatadavqa ahippnvnla evapilcagi tvykalkran vipgqwvtis 181 gacgglgsla iqyalamgyr vigidggnak rklfeqlgge ifidfteekd ivgaiikatn 241 ggshgvinvs vseaaieast rycrpngtvv lvgmpahayc nsdvfnqvvk sisivgscvg 301 nradtreald ffargliksp ihlaglsdvp eifakmekge ivgryvvets k // LOCUS NP_009704 278 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS9m MRPS9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009704 VERSION NP_009704.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178494.1 REFERENCE 1 (residues 1 to 278) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 278) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 278) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 278) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07261. Method: conceptual translation. FEATURES Location/Qualifiers source 1..278 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..278 /product="mitochondrial 37S ribosomal protein uS9m MRPS9" /calculated_mol_wt="31794" Region 158..278 /region_name="Ribosomal_S9" /note="Ribosomal protein S9/S16; pfam00380" /db_xref="CDD:459791" CDS 1..278 /gene="MRPS9" /locus_tag="YBR146W" /gene_synonym="uS9m" /coded_by="NM_001178494.1:1..837" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:852443" /db_xref="SGD:S000000350" ORIGIN 1 mfsrlslfrr aalapapmrm sfrtiyqkte delprrivpk latfysanpn hedrinrler 61 llrkyiklps qnnneaqqtk apwisfdeya ligggtklkp tqytqllyml nklhnidpql 121 tndeitsels qyykkssmls nnikiktlde fgrsiavgkr ksstakvfvv rgtgeilvng 181 rqlndyflkm kdresimypl qviesvgkyn ifattsgggp tgqaesimha iakalvvfnp 241 llksrlhkag vltrdyrhve rkkpgkkkar kmptwvkr // LOCUS NP_009705 296 aa linear PLN 30-JUN-2025 DEFINITION cationic amino acid transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_009705 VERSION NP_009705.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178495.1 REFERENCE 1 (residues 1 to 296) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 296) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 296) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 296) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07262. Method: conceptual translation. FEATURES Location/Qualifiers source 1..296 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..296 /product="cationic amino acid transporter" /calculated_mol_wt="33366" Region 13..73 /region_name="PQ-loop" /note="PQ loop repeat; pfam04193" /db_xref="CDD:461220" Region 208..265 /region_name="PQ-loop" /note="PQ loop repeat; pfam04193" /db_xref="CDD:461220" CDS 1..296 /gene="RTC2" /locus_tag="YBR147W" /gene_synonym="RRT11; YPQ3" /coded_by="NM_001178495.1:1..891" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23169667]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0015174 basic amino acid transmembrane transporter activity [PMID:23169667]" /experiment="EXISTENCE:mutant phenotype:GO:0034488 basic amino acid transmembrane export from vacuole [PMID:23169667]" /note="Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; positive regulation by Lys14p suggests that lysine may be the primary substrate; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; RTC2 has a paralog, YPQ1, that arose from the whole genome duplication" /db_xref="GeneID:852444" /db_xref="SGD:S000000351" ORIGIN 1 mklipiilna knlsgmagsi siccwivvfv pqiyenfrrq saeglsllfi vlwllgdifn 61 vmgammqnll ptmiilaayy tladlilliq cmwydkekks ilqevkknvd pvhlppanpi 121 netvlqdvfn eyepllprie eedsqsyssl elgrtivvke renffndfli vsgvliagil 181 swyisycsgl dngipkkkpa feqinlpaqi lgylsailyl gsripqivln fkrkscegvs 241 flfflfaclg ntsfiisvls aswligsagt llmdftvfiq fflyakpkye kilidn // LOCUS NP_009706 609 aa linear PLN 30-JUN-2025 DEFINITION Ysw1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009706 VERSION NP_009706.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178496.3 REFERENCE 1 (residues 1 to 609) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 609) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 609) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 609) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07263. On Jul 30, 2012 this sequence version replaced NP_009706.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..609 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..609 /product="Ysw1p" /calculated_mol_wt="70044" CDS 1..609 /gene="YSW1" /locus_tag="YBR148W" /coded_by="NM_001178496.3:1..1830" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:19465564]" /experiment="EXISTENCE:direct assay:GO:0031105 septin complex [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:19465564]" /note="Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane; YSW1 has a paralog, SPO21, that arose from the whole genome duplication" /db_xref="GeneID:852445" /db_xref="SGD:S000000352" ORIGIN 1 mssladtveg seakrgrfsn naltsdtgil qknstlrnwf lkptadlkns cedrveddvn 61 dvylndknsq ksveerklgr kvrsffkqtn snkdesvled eddalvwkkt snkcakkens 121 hdiqkgsftk kirnsifksa ndvkefrnen nlllpvelss ddeneshftd anshvmqsks 181 pekipskdqc ltkgaknkgl kkeyeksfee ysddsddefs patppenvle gpykfvfqtp 241 ntftsqpnit vendfhkggr hvidylnkkl atmnididlt sggkqnvswe eeldqlsdhv 301 iesitnhisk grmhaqekqd eleklklenl nlstlkqenl qhkqeinslk dnlesiskkn 361 ndlilemnkl kkkstnnktn eyistdenen eeitksnmgp gilelnvnet skklqqstfk 421 pskylpretr nnenrlkhle krifgleksl ekkkkqvrad svrldlnryt idqfltllks 481 lsevlqfhnv ygndlkendd niikietccs alnmkncfed ssfrlqensf krqlgplfan 541 infslidqlt mnfrfyersa nfqketiggl rmmlqdkdny iktlmqhlkk kestklikds 601 kngastlts // LOCUS NP_009707 344 aa linear PLN 30-JUN-2025 DEFINITION D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009707 VERSION NP_009707.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178497.3 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 344) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07264. On Jul 30, 2012 this sequence version replaced NP_009707.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..344 /product="D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA1" /EC_number="1.1.1.117" /calculated_mol_wt="38753" Region 22..321 /region_name="AKR_AKR3C1" /note="Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; cd19119" /db_xref="CDD:381345" Site order(39..41,66,70..71,100,131..132,192..193,214,240..246, 256,268,283..288,291,294..295) /site_type="active" /db_xref="CDD:381345" Site order(66,71,100,131) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381345" CDS 1..344 /gene="ARA1" /locus_tag="YBR149W" /coded_by="NM_001178497.3:1..1035" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9920381]" /experiment="EXISTENCE:direct assay:GO:0005975 carbohydrate metabolic process [PMID:9920381]" /experiment="EXISTENCE:direct assay:GO:0045149 acetoin metabolic process [PMID:33845171]" /experiment="EXISTENCE:direct assay:GO:0045290 D-arabinose 1-dehydrogenase [NAD(P)+] activity [PMID:9920381]" /experiment="EXISTENCE:direct assay:GO:0052588 diacetyl reductase ((S)-acetoin forming) (NAD+) activity [PMID:33845171]" /experiment="EXISTENCE:mutant phenotype:GO:0005975 carbohydrate metabolic process [PMID:9920381]" /note="NADP+ dependent arabinose dehydrogenase; involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product" /db_xref="GeneID:852446" /db_xref="SGD:S000000353" ORIGIN 1 msssvasten ivenmlhpkt teiyfslnng vripalglgt anpheklaet kqavkaaika 61 gyrhidtawa yetepfvgea ikelledgsi kredlfittk vwpvlwdevd rslneslkal 121 gleyvdlllq hwplcfekik dpkgisglvk tpvddsgktm yaadgdylet ykqlekiyld 181 pndhrvraig vsnfsieyle rlikecrvkp tvnqvethph lpqmelrkfc fmhdilltay 241 splgshgapn lkiplvkkla ekynvtgndl lisyhirqgt iviprslnpv risssiefas 301 ltkdelqeln dfgekypvrf idepfaailp eftgngpnld nlky // LOCUS NP_009708 1094 aa linear PLN 30-JUN-2025 DEFINITION Tbs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009708 VERSION NP_009708.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178498.1 REFERENCE 1 (residues 1 to 1094) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1094) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1094) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1094) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1094) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1094) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1094) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07265. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1094 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1094 /product="Tbs1p" /calculated_mol_wt="126773" Region 101..149 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(102,106,111..114,116,119,132) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(107,110,117,127,130,137) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 372..650 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..1094 /gene="TBS1" /locus_tag="YBR150C" /coded_by="NM_001178498.1:1..3285" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; associates with rDNA chromatin in vivo; TBS1 has a paralog, HAL9, that arose from the whole genome duplication" /db_xref="GeneID:852447" /db_xref="SGD:S000000354" ORIGIN 1 mnmdsgitss hgsmdktqkq ssewaanqkh nqrventrvl mgpavpampp vpsnfppvpt 61 gtimspqlsp fpdhrlrhhp lahmmpadkn flaynmesfk srvtkacdyc rkrkirctei 121 episgkcrnc ikynkdctfh fheelkrrre ealnnkgngk svkkprldke nkfkdenfdi 181 avrsrntsst dsspklhtnl sqeyigvsag ksasdkedtw pdfvpidrtv lekielnhtk 241 vagkvfvlee icknmkgtie klaekskidv idkeymkrpk rkqyskallt kqkmfhfrqn 301 vlshltdeef lspinemftt tfkysilqtk lvldfsfrsa sspssdnily plprlaiakr 361 llknikcpsl asllhivdvd qclqfadvhf dpakgrltss qafllniclc lgatvtnfee 421 kqelvdednh etyyfekfel wrlrsftfln svyyyhklsv aradmtalka llllakfaqq 481 kisassavkv lsvaikvald lrlnlhstye dleldeiikr rrlwcycfst dkffsvvlsr 541 ppflkeentd vltdesyvel frdkilpnls ikyddskleg vkdivsvvnl lanhleyvpy 601 iqsyflsrls liesqiyysc fsirttlddt ldeiienvle nqkaldrmrd dlptilslen 661 ykenmrilsl dsskldfevs ccttillhlr wyhqkitlsl fvisiigdnl dqressrhdi 721 aeiirrsrld fkrncievln ilkdfeyypt vqneflyfsl ttvfsmflyl seimvndeha 781 metgyiigll rdthtrmlgs eerclsvhnl kwqtslffyt fflrstmekf nltskyakfy 841 afdsnyyegv lnrlvkhtre skddmvellk tsfinkekma afgsfvtedq ekmevsfnif 901 neitiqdlnf lqfssipklw enktlepgee yhhsngtntd nnettgaddt ddnnnnnnnn 961 nkngnnssst innnnnnysn snnndndnni nddddddddd dddddddddd ddndddysnn 1021 gadddeeddd ydrslfptgl aslldasype rtandyrden eqsnklfeki eghlehgvff 1081 ydrdfffknv cvkm // LOCUS NP_009709 316 aa linear PLN 30-JUN-2025 DEFINITION Apd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009709 VERSION NP_009709.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178499.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 316) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07266. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..316 /product="Apd1p" /calculated_mol_wt="35628" Region 70..309 /region_name="Suc_Fer-like" /note="Sucrase/ferredoxin-like; pfam06999" /db_xref="CDD:462062" CDS 1..316 /gene="APD1" /locus_tag="YBR151W" /coded_by="NM_001178499.1:1..951" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:30879301]" /note="2Fe-2S cytosolic hypothetical protein; bishistidinyl coordinated, non-Rieske [2Fe-2S] cluster containing thiredoxin-like ferredoxin; required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm; homologous to AIM32" /db_xref="GeneID:852448" /db_xref="SGD:S000000355" ORIGIN 1 maflnifkqk rgdeasqlsa kgreeisqsi kicksddaan ehscsgdckt eieegeqafa 61 klkiehetpl lnssktpkih fvvptsqidw qhdacledpk svqykisqwc dknsakfsnv 121 gtgktlncav sslpkdimdi dvmrgtknnv lilpyfiwln dlrsddveat ldglvpdlld 181 enisreklle trpnvavare rafvficsht trdkrcgita pylkkvfdsk lqehglyrdn 241 sdyraegvki afvnhvgghk faanvqiylr npntliwlgr vtptivpsiv ehlivpeept 301 lpfpekvrci kkyqsw // LOCUS NP_009710 291 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit SPP381 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009710 VERSION NP_009710.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178500.3 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 291) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07267. On Jul 30, 2012 this sequence version replaced NP_009710.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..291 /product="U4/U6-U5 snRNP complex subunit SPP381" /calculated_mol_wt="33641" CDS 1..291 /gene="SPP381" /locus_tag="YBR152W" /coded_by="NM_001178500.3:1..876" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:9858581|PMID:10449419]" /experiment="EXISTENCE:genetic interaction:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:9858581]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9858581|PMID:10449419]" /note="mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p; relocalizes to the cytosol in response to hypoxia; temperature-sensitive phenotype of prp38-1 mutant can be suppressed by human homolog of SPP381, MFAP1" /db_xref="GeneID:852449" /db_xref="SGD:S000000356" ORIGIN 1 msfrhfkrrl dtssadesss adeehpdqnv slteksasls hsdlggeiln gtgknrtpnd 61 gqesnesdgs pesdespese essdnsdssd sddmrplprp lfmkkkannl qkatkidqpw 121 naqddarvlq tkkenmikni dkanqvakny etmklrlntn ystneelikq clllddndev 181 dsekerqkwf erqnerkqkh rriqlakqre seeyeakrfe amqkgkdgnt kydvildkek 241 ekldhkkqrs aekvekshnn nrykitrtkn vefgdlgkns rdyeeteysv i // LOCUS NP_009711 244 aa linear PLN 30-JUN-2025 DEFINITION 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009711 VERSION NP_009711.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178501.3 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 244) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07268. On Jul 30, 2012 this sequence version replaced NP_009711.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..244 /product="2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase" /EC_number="1.1.1.302" /calculated_mol_wt="26985" Region 28..241 /region_name="ribD_Cterm" /note="riboflavin-specific deaminase C-terminal domain; TIGR00227" /db_xref="CDD:129330" CDS 1..244 /gene="RIB7" /locus_tag="YBR153W" /coded_by="NM_001178501.3:1..735" /experiment="EXISTENCE:direct assay:GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity [PMID:23620735]" /experiment="EXISTENCE:mutant phenotype:GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase activity [PMID:4555411]" /experiment="EXISTENCE:mutant phenotype:GO:0009231 riboflavin biosynthetic process [PMID:5366000]" /note="Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway" /db_xref="GeneID:852450" /db_xref="SGD:S000000357" ORIGIN 1 msltplcedl pqflqnylpn agqtentivp fvtltyaqsl darvsrgpgv rttishpetk 61 tmthylrhhh dgilvgsgtv ladnpglnck wgpdpaansp rpiiidtkqk wrfdgskmqe 121 lfikrqgkpp ivvvtsepii keqhvdyaic pindttklvd wkklfeilke efnirsvmve 181 gganvinqll lrsdivnsli itigstflgs sgtevsppqt vnlkdmswwk gitdvvlcar 241 ladd // LOCUS NP_009712 215 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase core subunit RPB5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009712 VERSION NP_009712.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178502.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 215) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07269. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..215 /product="DNA-directed RNA polymerase core subunit RPB5" /calculated_mol_wt="24948" Region 6..215 /region_name="PLN03111" /note="DNA-directed RNA polymerase II subunit family protein; Provisional; cl42850" /db_xref="CDD:456195" CDS 1..215 /gene="RPB5" /locus_tag="YBR154C" /coded_by="NM_001178502.1:1..648" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:8288647|PMID:3905793|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:2186966|PMID:1331084|PMID:2183013]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:genetic interaction:GO:0006366 transcription by RNA polymerase II [PMID:9860960]" /experiment="EXISTENCE:mutant phenotype:GO:0006360 transcription by RNA polymerase I [PMID:17179178]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:9860960|PMID:17179178]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:17179178]" /note="RNA polymerase subunit ABC27; common to RNA polymerases I, II, and III; contacts DNA and affects transactivation" /db_xref="GeneID:852451" /db_xref="SGD:S000000358" ORIGIN 1 mdqenernis rlwrafrtvk emvkdrgyfi tqeevelple dfkakycdsm grpqrkmmsf 61 qanpteesis kfpdmgslwv efcdepsvgv ktmktfvihi qeknfqtgif vyqnnitpsa 121 mklvpsippa tietfneaal vvnithhelv pkhirlssde krellkryrl kesqlpriqr 181 adpvalylgl krgevvkiir ksetsgryas yricm // LOCUS NP_009713 385 aa linear PLN 30-JUN-2025 DEFINITION HSP70/90 family co-chaperone CNS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009713 VERSION NP_009713.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178503.1 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 385) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07270. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..385 /product="HSP70/90 family co-chaperone CNS1" /calculated_mol_wt="43981" Region 68..>218 /region_name="3a0801s09" /note="mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); TIGR00990" /db_xref="CDD:273380" Region 83..111 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(84,87..88,91..92,94,122,125..126,129..130,132..133, 156,159..160,163..164,167) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 120..150 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 221..374 /region_name="CTWD_TTC4" /note="C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; cd21381" /db_xref="CDD:439175" CDS 1..385 /gene="CNS1" /locus_tag="YBR155W" /coded_by="NM_001178503.1:1..1158" /experiment="EXISTENCE:direct assay:GO:0030544 Hsp70 protein binding [PMID:15044454]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:25380751]" /experiment="EXISTENCE:direct assay:GO:0051879 Hsp90 protein binding [PMID:12788914]" /experiment="EXISTENCE:genetic interaction:GO:0042026 protein refolding [PMID:9819421]" /experiment="EXISTENCE:physical interaction:GO:0005737 cytoplasm [PMID:15044454]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:15044454]" /note="TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70); stimulates ATPase activity of Ssa1p; ts mutants reduce Hsp82p function, overexpression suppresses phenotypes of HSP82 ts allele and cpr7 deletion; human homolog TTC4 complements yeast cns1 mutant" /db_xref="GeneID:852452" /db_xref="SGD:S000000359" ORIGIN 1 mssvnanggy tkpqkyvpgp gdpelppqls efkdktsdei lkemnrmpff mtkldetdga 61 ggenveleal kalayegeph eiaenfkkqg nelykakrfk darelyskgl avecedksin 121 eslyanraac elelknyrrc iedcskalti npknvkcyyr tskaffqlnk leeaksaatf 181 anqridpenk silnmlsvid rkeqelkake ekqqreaqer enkkimlesa mtlrnitnik 241 thspvellne gkirledpmd fesqliypal imyptqdefd fvgevseltt vqelvdlvle 301 gpqerfkkeg kenftpkkvl vfmetkaggl ikagkkltfh dilkkespdv plfdnalkiy 361 ivpkvesegw iskwdkqkal errsv // LOCUS NP_009714 698 aa linear PLN 30-JUN-2025 DEFINITION Sli15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009714 VERSION NP_009714.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178504.3 REFERENCE 1 (residues 1 to 698) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 698) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 698) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 698) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07271. On Jul 30, 2012 this sequence version replaced NP_009714.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..698 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..698 /product="Sli15p" /calculated_mol_wt="79055" Region 632..680 /region_name="INCENP_ARK-bind" /note="Inner centromere protein, ARK binding region; pfam03941" /db_xref="CDD:461100" CDS 1..698 /gene="SLI15" /locus_tag="YBR156C" /coded_by="NM_001178504.3:1..2097" /experiment="EXISTENCE:direct assay:GO:0005828 kinetochore microtubule [PMID:11724818]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:11724818]" /experiment="EXISTENCE:direct assay:GO:0032133 chromosome passenger complex [PMID:19158380]" /experiment="EXISTENCE:direct assay:GO:0051233 spindle midzone [PMID:12566427]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:10385519]" /experiment="EXISTENCE:mutant phenotype:GO:0030295 protein kinase activator activity [PMID:10385519]" /experiment="EXISTENCE:mutant phenotype:GO:0032185 septin cytoskeleton organization [PMID:17652458]" /experiment="EXISTENCE:mutant phenotype:GO:0032465 regulation of cytokinesis [PMID:16615892]" /note="Subunit of the conserved chromosomal passenger complex (CPC); complex regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly; other complex members are Ipl1p, Bir1p, and Nbl1p" /db_xref="GeneID:852453" /db_xref="SGD:S000000360" ORIGIN 1 mdwaikaark ktqrkpgstr siietlddln nlttdahsei nqrlyessew lrnnvymntl 61 kyedkkmees lispenthnk mdvefpkmkg eyelsnsqnd aakdvtktpr nglhndksit 121 pkslrrkevt egmnrfsihd tnkspvepln svkvdanese ksspwspykv ekvlresskt 181 sespintkrf dnqtwaakee menepilqal kkaesvkvkp ppnsgiarsq rrsnmfvplp 241 nkdpliiqhi pptkssgsip kvrtvkespi afkkkstins pairavensd tagstkassv 301 fdrlssiptk sfenkisrgn vghkyssssi dltgspmkkv sqkfksinst dtdmqealrd 361 ifsvknkitk nnspkgknsr kssiprfdkt slkltthkkl aiiaeqkkks khssdvhktg 421 srphsisptk isvdssspsk evknyyqspv rgylrptkas ispnknknlt tsqtphrlki 481 kektlrklsp niadiskpes rksknyrltn lqllppaeae rddlkkkfdk rlsgimrsqq 541 ehhrrkqekq krmshleqdl kkqtsfsndy kdirlkesla pfdnhvrdti nkntafstdn 601 ilatintvdh reiignvtpk iasvndslpe intdsedeas vtlaawaksp ylqeqlirqq 661 dinpqtifgp ipplhtdeif pnprlnrlkp rqivpkrs // LOCUS NP_009715 255 aa linear PLN 30-JUN-2025 DEFINITION Ics2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009715 VERSION NP_009715.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178505.3 REFERENCE 1 (residues 1 to 255) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 255) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 255) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 255) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07272. On Jul 30, 2012 this sequence version replaced NP_009715.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..255 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..255 /product="Ics2p" /calculated_mol_wt="28641" CDS 1..255 /gene="ICS2" /locus_tag="YBR157C" /coded_by="NM_001178505.3:1..768" /note="hypothetical protein; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization" /db_xref="GeneID:852454" /db_xref="SGD:S000000361" ORIGIN 1 mgkfeqkere ristfsfptt gsqsstsiks lgsplygrfs slsstesqfd sskqpheyek 61 sfyfeesqge alfnklktys fpgdkdgvkt rrnssicprk pnavsplrve snelsshshs 121 rslsheltkp sgrrksyhrk shaisfsrsc kpnfidgyds nssigvnsrk tslassfldk 181 eyhsspdtsy thqmspknti mntneqlrrn asgrfgslke faeknqinie gkifahkvet 241 gdilqplidl didnk // LOCUS NP_009716 549 aa linear PLN 30-JUN-2025 DEFINITION Amn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009716 VERSION NP_009716.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178506.1 REFERENCE 1 (residues 1 to 549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 549) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07273. Method: conceptual translation. FEATURES Location/Qualifiers source 1..549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..549 /product="Amn1p" /calculated_mol_wt="62555" Region 285..509 /region_name="AMN1" /note="Antagonist of mitotic exit network protein 1; cd09293" /db_xref="CDD:187754" Region 314..337 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 338..363 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 364..389 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 390..417 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 418..443 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 444..471 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 472..493 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" CDS 1..549 /gene="AMN1" /locus_tag="YBR158W" /gene_synonym="CST13; ICS4" /coded_by="NM_001178506.1:1..1650" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12628189]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12628189]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12628189]" /experiment="EXISTENCE:genetic interaction:GO:0001100 negative regulation of exit from mitosis [PMID:12628189]" /experiment="EXISTENCE:genetic interaction:GO:2001042 negative regulation of septum digestion after cytokinesis [PMID:30273335]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:12628189]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:12628189]" /experiment="EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:30273335]" /experiment="EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:12628189]" /experiment="EXISTENCE:mutant phenotype:GO:0032984 protein-containing complex disassembly [PMID:12628189]" /experiment="EXISTENCE:mutant phenotype:GO:2001042 negative regulation of septum digestion after cytokinesis [PMID:30273335]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:12628189]" /note="Modulator of cell separation and mitotic exit; inhibits separation through Ub-dependent Ace2p proteolysis; part of a daughter-specific switch induced by the mitotic exit network that inhibits exit and resets the cell cycle after the execution of MEN function, blocking Tem1p and Cdc15 association; required for chromosome stability and multiple mitotic checkpoints; regulated by SCF; haploid transcription regulated by Ste12p; contains 12 degenerate leucine-rich repeat motifs and an atypical F-box" /db_xref="GeneID:852455" /db_xref="SGD:S000000362" ORIGIN 1 mklervssng sfkrgrdiqs lespctrplk kmspspsfts lkmekpfkdi vrkygghlhq 61 ssynpgsskv elvrpdlslk tdqsflqssv qttpnkkscn eylstpeatp lkntatenaw 121 atsrvvsass lsivtpteik nilvdefsel klgqpltaqh qrshavfeip eiveniikmi 181 vslesanipk erpclrrnpq syehsllmyk deerakkaws aaqqlrdppl vghkekkqga 241 lfscmmvnrl wlnvtrpflf kslhfksvhn fkeflrtsqe ttqvmrpshf ilhklhqvtq 301 pdierlsrme cqnlkwlefy vcpritppls wfdnlhklek liipgnknid dnfllrlsqs 361 ipnlkhlvlr acdnvsdsgv vcialncpkl ktfnigrhrr gnlitsvslv algkytqvet 421 vgfagcdvdd agiwefarln gknverlsln scrlltdysl pilfalnsfp nlavleirnl 481 dkitdvrhfv kynlwkksld apilieacer itklidqeen rvkrinslva lkdmtawvna 541 ddeiennvd // LOCUS NP_009717 347 aa linear PLN 30-JUN-2025 DEFINITION ketoreductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009717 VERSION NP_009717.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178507.1 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 347) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07274. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..347 /product="ketoreductase" /EC_number="1.1.1.330" /calculated_mol_wt="38577" Region 62..310 /region_name="17beta-HSD1_like_SDR_c" /note="17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs; cd05356" /db_xref="CDD:187614" Site order(69,71..74,93..95,118..120,147..149,172,208..210,223, 227,253..256,258..259) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:187614" Site order(173,210,223,227) /site_type="active" /db_xref="CDD:187614" CDS 1..347 /gene="IFA38" /locus_tag="YBR159W" /coded_by="NM_001178507.1:1..1044" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12087109]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:23263984]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:23263984]" /experiment="EXISTENCE:mutant phenotype:GO:0030497 fatty acid elongation [PMID:12087109]" /experiment="EXISTENCE:mutant phenotype:GO:0042761 very long-chain fatty acid biosynthetic process [PMID:23263984]" /experiment="EXISTENCE:mutant phenotype:GO:0045703 ketoreductase activity [PMID:12087109]" /note="Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides" /db_xref="GeneID:852456" /db_xref="SGD:S000000363" ORIGIN 1 mtfmqqlqea gerfrcingl lwvvfglgvl kcttlslrfl alifdlfllp avnfdkygak 61 tgkycaitga sdgigkefar qmakrgfnlv lisrtqskle alqkeledqh hvvvkilaid 121 iaedkesnye sikelcaqlp itvlvnnvgq shsipvpfle teekelrnii tinntatlli 181 tqiiapkive tvkaenkksg trgliltmgs fggliptpll atysgsksfl qgwsnslage 241 lskdaidvel iisylvtssm skirrsslmi pnpqqfvkst lrsvgrrcgs qeryatmtpy 301 wahavyqfvi tetfgvyski vnsinysfhk siriralkka arqvkke // LOCUS NP_009718 298 aa linear PLN 30-JUN-2025 DEFINITION cyclin-dependent serine/threonine-protein kinase CDC28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009718 VERSION NP_009718.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178508.3 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 298) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07275. On Jul 30, 2012 this sequence version replaced NP_009718.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..298 /product="cyclin-dependent serine/threonine-protein kinase CDC28" /EC_number="2.7.11.22" /calculated_mol_wt="33930" Region 8..295 /region_name="STKc_CDK1_CdkB_like" /note="Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase; cd07835" /db_xref="CDD:270829" Site order(14..17,22,38,40,57,71,88..91,94,96..97,136,138, 140..141,143,154,157,169,171..174,176,214..215) /site_type="active" /db_xref="CDD:270829" Site order(14..17,22,38,40,71,88..91,94,97,140..141,143,154) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270829" Site order(44,49..51,53,56..57,59..60,63..64,78,125,128..131, 159..161,163..164,168..169,281,285..287) /site_type="other" /note="CDK/cyclin interface [polypeptide binding]" /db_xref="CDD:270829" Site order(57,96,136,138,157,169,171..174,176,214..215) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270829" Site 153..176 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270829" CDS 1..298 /gene="CDC28" /locus_tag="YBR160W" /gene_synonym="CDK1; HSL5; SRM5" /coded_by="NM_001178508.3:1..897" /experiment="EXISTENCE:direct assay:GO:0000082 G1/S transition of mitotic cell cycle [PMID:2142620]" /experiment="EXISTENCE:direct assay:GO:0000086 G2/M transition of mitotic cell cycle [PMID:32083180]" /experiment="EXISTENCE:direct assay:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:1849458|PMID:2142620]" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:22689984]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8930895|PMID:32083180|PMID:21498574|PMID:24319056|PM ID:23314252|PMID:16096060|PMID:22689984|PMID:27203178|PMID :12050115|PMID:25602519|PMID:22563681|PMID:22521784]" /experiment="EXISTENCE:direct assay:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:27068241|PMID:2142620]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14685274]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:3312233]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17560371]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12554645]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0010571 positive regulation of nuclear cell cycle DNA replication [PMID:14747467]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:20855529]" /experiment="EXISTENCE:direct assay:GO:0045892 negative regulation of DNA-templated transcription [PMID:14993267]" /experiment="EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:1652372]" /experiment="EXISTENCE:direct assay:GO:0045930 negative regulation of mitotic cell cycle [PMID:10074450]" /experiment="EXISTENCE:direct assay:GO:0051446 positive regulation of meiotic cell cycle [PMID:16814718]" /experiment="EXISTENCE:direct assay:GO:1905634 regulation of protein localization to chromatin [PMID:25602519]" /experiment="EXISTENCE:genetic interaction:GO:0000706 meiotic DNA double-strand break processing [PMID:20150422]" /experiment="EXISTENCE:genetic interaction:GO:0010568 regulation of budding cell apical bud growth [PMID:17417630]" /experiment="EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:16688214]" /experiment="EXISTENCE:genetic interaction:GO:0010898 positive regulation of triglyceride catabolic process [PMID:19150427]" /experiment="EXISTENCE:genetic interaction:GO:0030163 protein catabolic process [PMID:21993622]" /experiment="EXISTENCE:genetic interaction:GO:0032210 regulation of telomere maintenance via telomerase [PMID:19135888]" /experiment="EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:1652372]" /experiment="EXISTENCE:genetic interaction:GO:0090307 mitotic spindle assembly [PMID:21558801]" /experiment="EXISTENCE:genetic interaction:GO:1901319 positive regulation of trehalose catabolic process [PMID:27203179]" /experiment="EXISTENCE:genetic interaction:GO:1990758 mitotic sister chromatid biorientation [PMID:22056777]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:22056777]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:22056777]" /experiment="EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:21841787]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:8930895|PMID:21841787|PMID:22521784]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:22563681]" /experiment="EXISTENCE:mutant phenotype:GO:0006370 7-methylguanosine mRNA capping [PMID:22689984]" /experiment="EXISTENCE:mutant phenotype:GO:0006892 post-Golgi vesicle-mediated transport [PMID:22767578]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:20825495]" /experiment="EXISTENCE:mutant phenotype:GO:0010568 regulation of budding cell apical bud growth [PMID:17417630]" /experiment="EXISTENCE:mutant phenotype:GO:0010570 regulation of filamentous growth [PMID:9891070]" /experiment="EXISTENCE:mutant phenotype:GO:0010571 positive regulation of nuclear cell cycle DNA replication [PMID:4580573|PMID:12783856|PMID:14747467]" /experiment="EXISTENCE:mutant phenotype:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:16688214|PMID:8887667]" /experiment="EXISTENCE:mutant phenotype:GO:0010898 positive regulation of triglyceride catabolic process [PMID:19150427]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:21098119]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:29263158]" /experiment="EXISTENCE:mutant phenotype:GO:0034504 protein localization to nucleus [PMID:19188495]" /experiment="EXISTENCE:mutant phenotype:GO:0045819 positive regulation of glycogen catabolic process [PMID:27203179]" /experiment="EXISTENCE:mutant phenotype:GO:0045875 negative regulation of sister chromatid cohesion [PMID:21549314]" /experiment="EXISTENCE:mutant phenotype:GO:0045892 negative regulation of DNA-templated transcription [PMID:14993267|PMID:12081645]" /experiment="EXISTENCE:mutant phenotype:GO:0045931 positive regulation of mitotic cell cycle [PMID:7002718|PMID:2165600]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22689984]" /experiment="EXISTENCE:mutant phenotype:GO:0051446 positive regulation of meiotic cell cycle [PMID:16814718|PMID:2680756]" /experiment="EXISTENCE:mutant phenotype:GO:0051447 negative regulation of meiotic cell cycle [PMID:12081645]" /experiment="EXISTENCE:mutant phenotype:GO:0090169 regulation of spindle assembly [PMID:21558801]" /experiment="EXISTENCE:mutant phenotype:GO:1901319 positive regulation of trehalose catabolic process [PMID:27203179]" /experiment="EXISTENCE:mutant phenotype:GO:1902889 protein localization to spindle microtubule [PMID:22521784]" /experiment="EXISTENCE:mutant phenotype:GO:1903500 negative regulation of mitotic actomyosin contractile ring assembly [PMID:24413167]" /experiment="EXISTENCE:mutant phenotype:GO:1904291 positive regulation of mitotic DNA damage checkpoint [PMID:15496928]" /experiment="EXISTENCE:mutant phenotype:GO:1905168 positive regulation of double-strand break repair via homologous recombination [PMID:15496928]" /experiment="EXISTENCE:mutant phenotype:GO:1990139 protein localization to nuclear periphery [PMID:20702586]" /experiment="EXISTENCE:mutant phenotype:GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining [PMID:19699692]" /note="Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant" /db_xref="GeneID:852457" /db_xref="SGD:S000000364" ORIGIN 1 msgelanykr lekvgegtyg vvykaldlrp gqgqrvvalk kirlesedeg vpstaireis 61 llkelkddni vrlydivhsd ahklylvfef ldldlkryme gipkdqplga divkkfmmql 121 ckgiaychsh rilhrdlkpq nllinkdgnl klgdfglara fgvplrayth eivtlwyrap 181 evllggkqys tgvdtwsigc ifaemcnrkp ifsgdseidq ifkifrvlgt pneaiwpdiv 241 ylpdfkpsfp qwrrkdlsqv vpsldprgid lldkllaydp inrisarraa ihpyfqes // LOCUS NP_009719 376 aa linear PLN 30-JUN-2025 DEFINITION mannosylinositol phosphorylceramide synthase catalytic subunit CSH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009719 VERSION NP_009719.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178509.3 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 376) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07276. On Jul 30, 2012 this sequence version replaced NP_009719.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..376 /product="mannosylinositol phosphorylceramide synthase catalytic subunit CSH1" /EC_number="2.4.1.370" /calculated_mol_wt="44251" Region 62..191 /region_name="OCH1" /note="Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]; COG3774" /db_xref="CDD:442988" CDS 1..376 /gene="CSH1" /locus_tag="YBR161W" /coded_by="NM_001178509.3:1..1131" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006688 glycosphingolipid biosynthetic process [PMID:12954640]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:12954640]" /experiment="EXISTENCE:mutant phenotype:GO:0103064 inositol phosphorylceramide mannosyltransferase activity [PMID:12954640]" /note="Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication" /db_xref="GeneID:852458" /db_xref="SGD:S000000365" ORIGIN 1 mkkelkilii aniallisii hytfdlltlc iddtskdalt deqlnppngf nstfyesppq 61 lipkiihqty ktndipeqwv kgrqkcidlh pdytyilwtd emsdtfikqe ypwfldtfrs 121 yeypierada iryfilshyg giyidlddgc errldpllkv paflrktspt gvsndvmgsv 181 prhpfflkvi kslkhykknw yipymtimgs tgplfisvvw kqykrwsnta engavrilqp 241 adykmhnnsf fsiskgsswh tgdanfmktl enhilscvvt gfifgffily geftfytwlc 301 sgpfnnkryy iqwlsdkfkl hkwkltssyk nkekrrnptr heynsrgkrl rkdsnipyds 361 vfldieknha kftdlt // LOCUS NP_009720 455 aa linear PLN 30-JUN-2025 DEFINITION Tos1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009720 VERSION NP_009720.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178510.1 REFERENCE 1 (residues 1 to 455) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 455) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 455) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 455) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07277. Method: conceptual translation. FEATURES Location/Qualifiers source 1..455 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..455 /product="Tos1p" /EC_number="3.2.1.39" /calculated_mol_wt="47863" Region 39..97 /region_name="YJL171C_Tos1_N" /note="Cell wall protein YJL171C/Tos1, N-terminal; pfam10290" /db_xref="CDD:463045" Region 223..441 /region_name="YJL171C_Tos1_C" /note="Cell wall protein YJL171C/Tos1, C-terminal; pfam10287" /db_xref="CDD:431198" CDS 1..455 /gene="TOS1" /locus_tag="YBR162C" /coded_by="NM_001178510.1:1..1368" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460|PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Covalently-bound cell wall hypothetical protein; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C" /db_xref="GeneID:852459" /db_xref="SGD:S000000366" ORIGIN 1 mlqklsmtal vglfssvvsl vnadctysgg nyycaqtdai iysnvglsat yqdvtnmdes 61 scactqadft asgslapfne elsvhfrgpi ellqfgvyyp ngesnalkkr sekqsiesck 121 egeavvsrhk hqhkrdvave yvqvtstvyv dsngqtvtad stntvvgpav pssytkdstv 181 lsssaqavet sesqssisss kttssaaaas sssssssntn gdwsrgsyfv pgstsnctfm 241 nnqggtagsg vwsscfgnsi sfaasdgvsg aasaqalgdv tiksgnefmi fsgeecsgnn 301 gdcgyyregi payhgfggad kifvfefsmp sdtsgsaynq dmpaiwllna kiprtlqygd 361 ascscwktgc gemdlfeilt agsdklishi hdgqdggtqd yferptdgtl kaavifnssd 421 ktihiievde sfdatlsddv vdqwlsksgs saalp // LOCUS NP_009721 65 aa linear PLN 30-JUN-2025 DEFINITION Ysy6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009721 VERSION NP_009721.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180059.1 REFERENCE 1 (residues 1 to 65) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 65) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 65) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 65) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 65) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 65) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 65) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07278. Method: conceptual translation. FEATURES Location/Qualifiers source 1..65 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..65 /product="Ysy6p" /calculated_mol_wt="7234" Region 4..61 /region_name="RAMP4" /note="Ribosome associated membrane protein RAMP4; pfam06624" /db_xref="CDD:461965" CDS 1..65 /gene="YSY6" /locus_tag="YBR162W-A" /coded_by="NM_001180059.1:1..198" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0009306 protein secretion [PMID:10469658]" /note="hypothetical protein; expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion" /db_xref="GeneID:852460" /db_xref="SGD:S000002158" ORIGIN 1 mavqtprqrl anakfnknne kyrkygkkke gktektapvi sktwlgillf llvgggvlql 61 isyil // LOCUS NP_009722 585 aa linear PLN 30-JUN-2025 DEFINITION Exo5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009722 VERSION NP_009722.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178511.3 REFERENCE 1 (residues 1 to 585) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 585) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 585) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 585) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07279. On Jul 30, 2012 this sequence version replaced NP_009722.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..585 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..585 /product="Exo5p" /calculated_mol_wt="67439" Region 126..560 /region_name="Exo5" /note="Exonuclease V - a 5' deoxyribonuclease; pfam09810" /db_xref="CDD:430843" CDS 1..585 /gene="EXO5" /locus_tag="YBR163W" /gene_synonym="DEM1" /coded_by="NM_001178511.3:1..1758" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity [PMID:20086101]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:20086101]" /note="Mitochondrial 5'-3' exonuclease and sliding exonuclease; required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2" /db_xref="GeneID:852461" /db_xref="SGD:S000000367" ORIGIN 1 mlgralinky gflihprrfv hlndksldgt filpskknhm ydvptndpsg ilnasdidri 61 nnlpffdnts ptketntkeg allseklasv kelfgedpen psfinyrfpr glenpyfdiq 121 vnqlkkkrls vtqlcttqnw celrnfydfy sqnlsnqlln lkfqvqkgkk ihksledeth 181 pelnqyksft hnflaltkls mdidndmdal ldnwfnsinr lvslftkgdg hareivchgf 241 inledgklve hllnsdsktk enviisgvid hltlrnrhnh qvqkgaahld teyqswgnil 301 tnllsnlkel ksnneivisd iktrsvpkip siesviessk lqtmyykfff shlsqdmtqt 361 yhsflinaqr rgldvdapin ptkiltfilt nplfandvkn llyglpinhs afdndakgsn 421 tfdmtafndl ldrgptsfnv pieqdedsse stkcvslrdy ghfytkwktp ltlkyfaarl 481 sqiyfivgnl vsndlmieyy yhndnfhnii fpydplklgt hahdsamvwf ggrdmhpiep 541 tqknfntyck fcdyrhvcsw knknelklid lgkelkkiil essmk // LOCUS NP_009723 183 aa linear PLN 30-JUN-2025 DEFINITION Arf family GTPase ARL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009723 VERSION NP_009723.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178512.3 REFERENCE 1 (residues 1 to 183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 183) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07280. On Jul 30, 2012 this sequence version replaced NP_009723.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..183 /product="Arf family GTPase ARL1" /calculated_mol_wt="20303" Region 20..177 /region_name="Arl1" /note="ADP ribosylation factor 1 (Arf1); cd04151" /db_xref="CDD:206718" Site 25..32 /site_type="other" /note="G1 box" /db_xref="CDD:206718" Site order(27..33,46,49,71,127..128,130,160..162) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206718" Site order(27..28,32,36,48..55,77,82) /site_type="other" /note="putative GAP interaction site [polypeptide binding]" /db_xref="CDD:206718" Site 37..52 /site_type="other" /note="Switch I region" /db_xref="CDD:206718" Site order(49..53,58,68,72,78,80..82) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206718" Site 49 /site_type="other" /note="G2 box" /db_xref="CDD:206718" Site order(51..52,65,81..82,84,116) /site_type="active" /note="effector interaction site [active]" /db_xref="CDD:206718" Site order(52..59,62..67) /site_type="active" /note="interswitch region [active]" /db_xref="CDD:206718" Site order(68..76,78..81) /site_type="other" /note="Switch II region" /db_xref="CDD:206718" Site 68..71 /site_type="other" /note="G3 box" /db_xref="CDD:206718" Site 127..130 /site_type="other" /note="G4 box" /db_xref="CDD:206718" Site 160..162 /site_type="other" /note="G5 box" /db_xref="CDD:206718" CDS 1..183 /gene="ARL1" /locus_tag="YBR164C" /gene_synonym="DLP2" /coded_by="NM_001178512.3:1..552" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:9388248]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15077113|PMID:15564045]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:23345439|PMID:15975906]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:15975906]" /experiment="EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0000407 phagophore assembly site [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12210899|PMID:12052896]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:12052896]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:11840166]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0034067 protein localization to Golgi apparatus [PMID:26966233]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:26966233]" /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:16926193]" /note="Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; role in membrane organization at trans-Golgi network; required for delivery of Atg9p to the phagophore assembly site during autophagy under high temperature stress; required with Ypt6p for starvation-induced autophagy; required for the CVT pathway under non-starvation conditions; G protein of the Ras superfamily, similar to ADP-ribosylation factor" /db_xref="GeneID:852462" /db_xref="SGD:S000000368" ORIGIN 1 mgnifssmfd klwgsnkelr ililgldgag kttilyrlqi gevvttkpti gfnvetlsyk 61 nlklnvwdlg gqtsirpywr cyyadtaavi fvvdstdkdr mstaskelhl mlqeeelqda 121 allvfankqd qpgalsasev skelnlvelk drswsivass aikgegiteg ldwlidvike 181 eql // LOCUS NP_009724 277 aa linear PLN 30-JUN-2025 DEFINITION Ubs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009724 VERSION NP_009724.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178513.1 REFERENCE 1 (residues 1 to 277) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 277) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 277) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 277) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07281. Method: conceptual translation. FEATURES Location/Qualifiers source 1..277 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..277 /product="Ubs1p" /calculated_mol_wt="32066" CDS 1..277 /gene="UBS1" /locus_tag="YBR165W" /coded_by="NM_001178513.1:1..834" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10991951]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:10991951]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:10991951]" /note="Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p; functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity" /db_xref="GeneID:852463" /db_xref="SGD:S000000369" ORIGIN 1 maysltrkll kdwkyfmrhp ektqglfhvr phdsdlhlwh vvmyeprtsl evylllyigg 61 ndqdpyiimk clspnccfpi nrtvsmthln ylllkdlglq dllfhiwqpl fhiqatedlq 121 yspstvkfnr awnriiykdf ksyfpeligt lqpgdysivk sysknhnisn snggsvnefm 181 ssynaqshtf haqdnsknpy tnssigkssm lstlnnnnvn krthdynaid fmtknllacd 241 ddsihpvvss krsrtlacpd etndnrgseh ytkrkki // LOCUS NP_009725 452 aa linear PLN 30-JUN-2025 DEFINITION prephenate dehydrogenase (NADP(+)) [Saccharomyces cerevisiae S288C]. ACCESSION NP_009725 VERSION NP_009725.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178514.1 REFERENCE 1 (residues 1 to 452) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 452) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 452) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 452) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07282. Method: conceptual translation. FEATURES Location/Qualifiers source 1..452 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..452 /product="prephenate dehydrogenase (NADP(+))" /EC_number="1.3.1.13" /calculated_mol_wt="50792" Region 16..>283 /region_name="PRK08655" /note="prephenate dehydrogenase; Provisional" /db_xref="CDD:236326" CDS 1..452 /gene="TYR1" /locus_tag="YBR166C" /coded_by="NM_001178514.1:1..1359" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006571 tyrosine biosynthetic process [PMID:30771296]" /experiment="EXISTENCE:direct assay:GO:0008977 prephenate dehydrogenase (NAD+) activity [PMID:30771296]" /experiment="EXISTENCE:mutant phenotype:GO:0006570 tyrosine metabolic process [PMID:2697638]" /experiment="EXISTENCE:mutant phenotype:GO:0008977 prephenate dehydrogenase (NAD+) activity [PMID:2697638]" /note="Prephenate dehydrogenase involved in tyrosine biosynthesis; expression is dependent on phenylalanine levels" /db_xref="GeneID:852464" /db_xref="SGD:S000000370" ORIGIN 1 mvsedkieqw katkvigiig lgdmgllyan kftdagwgvi ccdreeyyde lkekyasakf 61 elvknghlvs rqsdyiiysv easniskiva tygpsskvgt ivggqtsckl peieafekyl 121 pkdcdiitvh slhgpkvnte gqplviinhr sqypesfefv nsvmaclksk qvyltyeehd 181 kitadtqavt haaflsmgsa wakikiypwt lgvnkwyggl envkvnislr iysnkwhvya 241 glaitnpsah qqilqyatsa telfslmidn keqeltdrll kakqfvfgkh tgllllddti 301 lekyslskss ignsnnckpv pnshlsllai vdswfqlgid pydhmicstp lfriflgvse 361 ylflkpglle qtidaaihdk sfikddlefv isarewssvv sfanfdiykk qfqsvqkffe 421 pmlpeanlig nemiktilsh ssdrsaaekr nt // LOCUS NP_009726 140 aa linear PLN 30-JUN-2025 DEFINITION ribonuclease P/MRP protein subunit POP7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009726 VERSION NP_009726.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178515.3 REFERENCE 1 (residues 1 to 140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 140) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07283. On Jul 30, 2012 this sequence version replaced NP_009726.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..140 /product="ribonuclease P/MRP protein subunit POP7" /EC_number="3.1.26.5" /calculated_mol_wt="15683" Region 28..137 /region_name="Rpp20" /note="Rpp20 subunit of nuclear RNase MRP and P; pfam12328" /db_xref="CDD:372048" CDS 1..140 /gene="POP7" /locus_tag="YBR167C" /gene_synonym="RPP2" /coded_by="NM_001178515.3:1..423" /experiment="EXISTENCE:direct assay:GO:0000171 ribonuclease MRP activity [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:26135751]" /experiment="EXISTENCE:direct assay:GO:0004526 ribonuclease P activity [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854|PMID:9618478]" /experiment="EXISTENCE:direct assay:GO:0005697 telomerase holoenzyme complex [PMID:27156450]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0000172 ribonuclease MRP complex [PMID:9618478]" /experiment="EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9620854|PMID:9618478]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9618478|PMID:9620854]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]" /note="Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA" /db_xref="GeneID:852465" /db_xref="SGD:S000000371" ORIGIN 1 malkknthnk stkrvtkhps lktlthkqih ttifvksttp yvsalkrink fldsvhkqgs 61 syvavlgmgk avektlalgc hfqdqknkki evytktievl devitegqad idmesdvedd 121 dketqlkkra vsgvelriyv // LOCUS NP_009727 413 aa linear PLN 30-JUN-2025 DEFINITION Pex32p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009727 VERSION NP_009727.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178516.3 REFERENCE 1 (residues 1 to 413) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 413) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 413) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 413) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07284. On Jul 30, 2012 this sequence version replaced NP_009727.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..413 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..413 /product="Pex32p" /calculated_mol_wt="48448" Region 24..408 /region_name="Pex24p" /note="Integral peroxisomal membrane peroxin; pfam06398" /db_xref="CDD:399414" CDS 1..413 /gene="PEX32" /locus_tag="YBR168W" /coded_by="NM_001178516.3:1..1242" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:14617799]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:14617799]" /note="Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p" /db_xref="GeneID:852466" /db_xref="SGD:S000000372" ORIGIN 1 mdtnsktkvq tenkkikakf ihnhgqkpsl iqitppmiss tlfhayplll ifdnalanim 61 wlsddkcltf iyltsiwlti sffipvetea shflpftkil rlwlgiisga flflsfmyyi 121 vsliaslrdt epptldeivv llesvldkle vlrnelnvwk klklsfdgvn kecsgkrlfc 181 rlflfgtifq iiimryispg tytrffiitg liyntssfqa tlrllwrfta vrnfyylgie 241 sfkissflpk hlkmeqiipl sqgraitvpl vevlpkllrd kkgddhihil qlllneqkdn 301 fgnedlkile ievyenqrrw yqnknwstkl lpyerqnyci eikntdgtlt mrsclppdgl 361 geeelpnnwh windnwdgtd wiysdsawke igqysslesf trsrkwkrrl fhl // LOCUS NP_009728 693 aa linear PLN 30-JUN-2025 DEFINITION adenyl-nucleotide exchange factor SSE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009728 VERSION NP_009728.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178517.1 REFERENCE 1 (residues 1 to 693) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 693) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 693) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 693) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07285. Method: conceptual translation. FEATURES Location/Qualifiers source 1..693 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..693 /product="adenyl-nucleotide exchange factor SSE2" /calculated_mol_wt="77490" Region 5..390 /region_name="ASKHA_ATPase-like" /note="ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; cl49607" /db_xref="CDD:483947" CDS 1..693 /gene="SSE2" /locus_tag="YBR169C" /coded_by="NM_001178517.1:1..2082" /experiment="EXISTENCE:direct assay:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:16688212]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:29507114]" /experiment="EXISTENCE:genetic interaction:GO:0042026 protein refolding [PMID:16688211]" /experiment="EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:29507114]" /note="Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication" /db_xref="GeneID:852467" /db_xref="SGD:S000000373" ORIGIN 1 mstpfgldlg nnnsvlavar nrgidvvvne vsnrstpslv gfgprnrylg esgktkqtsn 61 vkntvenlkr iiglkfkdpe fdienkffts klvqlkngkv gvevefggkt hvfsatqlta 121 mfidkvkhtv qeetkssitd vclavpvwys eeqryniada ariaglnpvr ivndvtaaav 181 sygvfkndlp gpeekpriig lvdighstyt csimafrkge mkvlgtaydk hfggrdfdra 241 itehfadqfk dkykidirkn pkaynrilia aeklkkvlsa nttapfsves vmddidvssq 301 lsreeleelv epllkrvtyp itnalaqakl tvndidfvei iggttripvl kksisdvfgk 361 plsstlnqde avakgaafic aihsptlrvr pfkfedidpy svsytwdkqv ddedrlevfp 421 anssypstkl itlhrtgdfs mkavythpsk lpkgtsttia kwsftgvkvp kdqdfipvkv 481 klrcdpsglh iienaytted itvqepvplp edapedaepq fkevtktikk dvlgmtaktf 541 alnpvelndl iekenelrnq dklvaetedr knaleeyiyt lraklddeys dfasdaekek 601 lknmlatten wlygdgddst kakyiakyee laslgniirg rylakeeekr qalranqets 661 kmndiaekla eqrraraasd dsddnndenm dld // LOCUS NP_009729 580 aa linear PLN 30-JUN-2025 DEFINITION nuclear protein localization protein 4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009729 VERSION NP_009729.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178518.1 REFERENCE 1 (residues 1 to 580) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 580) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 580) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 580) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07286. Method: conceptual translation. FEATURES Location/Qualifiers source 1..580 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..580 /product="nuclear protein localization protein 4" /calculated_mol_wt="65651" Region 1..580 /region_name="NPL4" /note="Nuclear pore protein [Nuclear structure]; COG5100" /db_xref="CDD:227431" CDS 1..580 /gene="NPL4" /locus_tag="YBR170C" /gene_synonym="HRD4" /coded_by="NM_001178518.1:1..1743" /experiment="EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873065|PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006274 DNA replication termination [PMID:31509741]" /experiment="EXISTENCE:direct assay:GO:0030894 replisome [PMID:31509741]" /experiment="EXISTENCE:direct assay:GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex [PMID:11598205|PMID:11733065]" /experiment="EXISTENCE:direct assay:GO:0036266 Cdc48p-Npl4p-Vms1p AAA ATPase complex [PMID:21070972]" /experiment="EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:11598205]" /experiment="EXISTENCE:direct assay:GO:1990112 RQC complex [PMID:23178123]" /experiment="EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:11740563]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11739805|PMID:11813000|PMID:11740563]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:20206597]" /experiment="EXISTENCE:mutant phenotype:GO:0051228 mitotic spindle disassembly [PMID:14636562]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:22505030]" /experiment="EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:18812321]" /experiment="EXISTENCE:mutant phenotype:GO:0072665 protein localization to vacuole [PMID:29444958]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579|PMID:21070972]" /experiment="EXISTENCE:mutant phenotype:GO:0099638 endosome to plasma membrane protein transport [PMID:36125415]" /experiment="EXISTENCE:mutant phenotype:GO:1900182 positive regulation of protein localization to nucleus [PMID:11598205|PMID:11733065]" /experiment="EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23358411]" /note="Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; K48-specific Ub chain binding receptor that assists Cdc48p in the dislocation of misfolded, polyubiquitinated ERAD substrates destined for proteasomal degradation; role in regulated destruction of ER membrane proteins, like HMG-CoA reductase (Hmg1/2p), cytosolic proteins (Fbp1p) and mislocalized proteins (Cse4p); mobilizes membrane-bound transcription factors by regulated Ub/proteasome-dependent processing; contains a UBX domain" /db_xref="GeneID:852468" /db_xref="SGD:S000000374" ORIGIN 1 mlirfrskng thrvscqend lfgtvieklv gnldpnadvd tftvcekpgq gihavselad 61 rtvmdlglkh gdmlilnysd kpanekdgvn veigsvgids kgirqhrygp lrikelavde 121 elekedglip rqksklckhg drgmceycsp lppwdkeyhe knkikhisfh sylkklnena 181 nkkengssyi splsepdfri nkrchnghep wprgicskcq psaitlqqqe frmvdhvefq 241 kseiinefiq awrytgmqrf gymygsysky dntplgikav veaiyeppqh deqdgltmdv 301 eqvknemlqi drqaqemgls rigliftdls dagagdgsvf ckrhkdsffl sslevimaar 361 hqtrhpnvsk yseqgffssk fvtcvisgnl egeidissyq vsteaealvt admisgstfp 421 smayindttd eryvpeifym ksneygitvk enakpafpvd yllvtlthgf pntdtetnsk 481 fvsstgfpws nrqamgqsqd yqelkkylfn vassgdfnll hekisnfhll lyinslqils 541 pdewkllies avkneweesl lklvssagwq tlvmilqesg // LOCUS NP_009730 206 aa linear PLN 30-JUN-2025 DEFINITION Sec63 complex subunit SEC66 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009730 VERSION NP_009730.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178519.3 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 206) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07287. On Jul 30, 2012 this sequence version replaced NP_009730.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..206 /product="Sec63 complex subunit SEC66" /calculated_mol_wt="24100" Region 27..197 /region_name="Sec66" /note="Preprotein translocase subunit Sec66; pfam09802" /db_xref="CDD:430836" CDS 1..206 /gene="SEC66" /locus_tag="YBR171W" /gene_synonym="HSS1; KAR7; SEC71" /coded_by="NM_001178519.3:1..621" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095|PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9275186]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9252322]" /experiment="EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7758110]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:32513868]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:15645503]" /experiment="EXISTENCE:mutant phenotype:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:8257795|PMID:32513868]" /experiment="EXISTENCE:physical interaction:GO:0031207 Sec62/Sec63 complex [PMID:8257795]" /note="Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec72p" /db_xref="GeneID:852469" /db_xref="SGD:S000000375" ORIGIN 1 msefnetkfs nngtffetee pivetksisv ytpliyvfil vvslvmfass yrkkqakkis 61 eqpsifdend ahdlyfqike msenekihek vlkaallnrg aesvrrslkl kelapqinll 121 ykngsigedy wkrfetevkl ielefkdtlq eaerlqpgwv qlfvmvckei cfnqalsrry 181 qsilkrkevc ikewelkinn dgrlvn // LOCUS NP_009731 740 aa linear PLN 30-JUN-2025 DEFINITION Smy2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009731 VERSION NP_009731.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178520.3 REFERENCE 1 (residues 1 to 740) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 740) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 740) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 740) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 740) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 740) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 740) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07288. On Jul 30, 2012 this sequence version replaced NP_009731.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..740 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..740 /product="Smy2p" /calculated_mol_wt="81266" Region 205..261 /region_name="GYF" /note="GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species; cd00072" /db_xref="CDD:238027" Site 219..235 /site_type="active" /note="proline binding motif [active]" /db_xref="CDD:238027" Site order(229,234..235) /site_type="active" /note="proline interaction residues [active]" /db_xref="CDD:238027" CDS 1..740 /gene="SMY2" /locus_tag="YBR172C" /coded_by="NM_001178520.3:1..2223" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:36288698]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:36288698]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17973654]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17973654]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:36288698]" /experiment="EXISTENCE:mutant phenotype:GO:0032984 protein-containing complex disassembly [PMID:36288698]" /experiment="EXISTENCE:mutant phenotype:GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system [PMID:36288698]" /experiment="EXISTENCE:physical interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17973654]" /note="GYF domain protein; involved in COPII vesicle formation; regulates Cdc48p function in transcription stress response; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; homologous to human GIGYF1 and GIGYF2; similar to S. pombe Mpd2; SMY2 has a paralog, SYH1, that arose from the whole genome duplication" /db_xref="GeneID:852470" /db_xref="SGD:S000000376" ORIGIN 1 miapdsqrlf gsfdeqfkdl kldsvdtenn nthgvstild sspasvnnnt ngavaasvnt 61 vpgstfrsnt pllggrhpls rtsslidsig iqraaspfss mkepfipqss gvmsssfwhg 121 dhpesrvstp vqqhpllqrn essssfsyaa nlgvnlsths lavditplst ptaaqshvnl 181 fpssdippnm smngmsqlpa pvsvesswry idtqgqihgp fttqmmsqwy iggyfastlq 241 isrlgstpet lgindifitl gelmtkleky dtdpfttfdk lhvqttssds inlnlapyas 301 gvaatgtika tendifkplt hdniwdmdgg ttskgvdikl asattisqtd eshkqeykst 361 tmlekgkkek sesvakalld eqekrnrelk rkeearlskk qkqkeddllk kqkeqkeqke 421 kealeaekqk ksektkkdtq tqtegfktsk dlpslnsssa npapwaskvk vnnaietsik 481 ngvsstgkkk geplglqqrn skeekqkeel ksvlnwanks slpsnqtidi ksqfqkspkg 541 mkessplkel edpnfieeqk klwekvqsss kqvkstssas tttsswttvt skgkapigtv 601 vspysktnts lnssltakts ttsttttfas mnnvsprqef ikwcksqmkl nsgitnnnvl 661 elllslptgp eskeliqeti yansdvmdgr rfatefikrr vacekqgddp lswnealals 721 gndddgwefq vvskkkgrkh // LOCUS NP_009732 148 aa linear PLN 30-JUN-2025 DEFINITION Ump1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009732 VERSION NP_009732.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178521.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 148) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07289. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..148 /product="Ump1p" /calculated_mol_wt="16629" Region 27..146 /region_name="UMP1" /note="Proteasome maturation factor UMP1; pfam05348" /db_xref="CDD:461627" CDS 1..148 /gene="UMP1" /locus_tag="YBR173C" /gene_synonym="RNS2" /coded_by="NM_001178521.1:1..447" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11922673]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11922673]" /experiment="EXISTENCE:direct assay:GO:0006974 DNA damage response [PMID:10975253]" /experiment="EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:17431397]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9491890]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:9491890]" /note="Chaperone required for correct maturation of the 20S proteasome; short-lived chaperone; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly" /db_xref="GeneID:852471" /db_xref="SGD:S000000377" ORIGIN 1 mnivpqdtfk sqvstdqdks vlssavpslp dtlrqqegga vplstqlndr hplestlknw 61 ettqrqrqme qyrqifgiae pmkrtmemei vnrtdfnpls tngsihrdil lnkecsidwe 121 dvypgtglqa stmvgddvhs kiekqlgi // LOCUS NP_009734 315 aa linear PLN 30-JUN-2025 DEFINITION Swd3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009734 VERSION NP_009734.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178523.1 REFERENCE 1 (residues 1 to 315) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 315) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 315) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 315) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07290. Method: conceptual translation. FEATURES Location/Qualifiers source 1..315 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..315 /product="Swd3p" /calculated_mol_wt="34623" Region 17..53 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <21..293 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 59..94 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 99..135 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 142..178 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 192..228 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 236..284 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 290..312 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..315 /gene="SWD3" /locus_tag="YBR175W" /gene_synonym="CPS30; SAF35" /coded_by="NM_001178523.1:1..948" /experiment="EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11805083|PMID:11742990]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:11742990]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11752412|PMID:11805083|PMID:11687631]" /experiment="EXISTENCE:mutant phenotype:GO:0042800 histone H3K4 methyltransferase activity [PMID:11752412|PMID:11805083]" /experiment="EXISTENCE:mutant phenotype:GO:1903341 regulation of meiotic DNA double-strand break formation [PMID:23246437]" /experiment="EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11742990|PMID:11687631|PMID:11752412]" /note="Essential subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5" /db_xref="GeneID:852472" /db_xref="SGD:S000000379" ORIGIN 1 mfqfvtpvgt qnglkatcak ispdgqflai tqglniliyd inrrtvsqtl vtsharpfse 61 lcwspdgqci atasddfsve iihlsygllh tfightapvi sltfnrkgnl lftssmdesi 121 kiwdtlngsl mktisahsea vvsvdvpmnd ssilssgsyd glirifdaet ghclktltyd 181 kdwkrengvv pisqvkfsen aryllvksld gvvkiwdcig gcvvrtfqvq plekgvlhhs 241 cgmdflnped gstplvisgy engdiycwns dtksllqlld gslyhhsspv msihcfgnim 301 cslalngdcc lwrwv // LOCUS NP_009735 312 aa linear PLN 30-JUN-2025 DEFINITION 3-methyl-2-oxobutanoate hydroxymethyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009735 VERSION NP_009735.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178524.3 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 312) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07291. On Jul 30, 2012 this sequence version replaced NP_009735.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..312 /product="3-methyl-2-oxobutanoate hydroxymethyltransferase" /EC_number="2.1.2.11" /calculated_mol_wt="34334" Region 27..289 /region_name="Pantoate_transf" /note="Ketopantoate hydroxymethyltransferase; pfam02548" /db_xref="CDD:460588" CDS 1..312 /gene="ECM31" /locus_tag="YBR176W" /coded_by="NM_001178524.3:1..939" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14562095|PMID:14576278|PMID:16823961|P MID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0003864 3-methyl-2-oxobutanoate hydroxymethyltransferase activity [PMID:11154694]" /experiment="EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]" /note="Ketopantoate hydroxymethyltransferase; required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate" /db_xref="GeneID:852474" /db_xref="SGD:S000000380" ORIGIN 1 mnimkrqlct sskrffstak nvvkyntiqd irnkyftgtp lsmctaydfi tatwvnkanc 61 dlllvgdsla mtslgydsti tlslnefkyh vasvcraegs smvvvdmpfg tfesgisdgl 121 knaidimkld skvtsvkvev gsytkdkyam kfieelcsrg ipvmahiglt pqkvhslggy 181 kvqgsksllq mqelyetamq lqkigcwsil iecvphkmaq fitsklsvpt igigagngts 241 gqvlvisdll gmqgdsvpkf vkqavnmtdi atqglkeyia svedrtfper gthtfkvked 301 lwneflssin ek // LOCUS NP_009736 451 aa linear PLN 30-JUN-2025 DEFINITION medium-chain fatty acid ethyl ester synthase/esterase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009736 VERSION NP_009736.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178525.3 REFERENCE 1 (residues 1 to 451) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 451) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 451) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 451) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07292. On Jul 30, 2012 this sequence version replaced NP_009736.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..451 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..451 /product="medium-chain fatty acid ethyl ester synthase/esterase" /EC_number="2.3.1.84" /calculated_mol_wt="51124" Region 166..446 /region_name="YheT" /note="Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; COG0429" /db_xref="CDD:440198" CDS 1..451 /gene="EHT1" /locus_tag="YBR177C" /coded_by="NM_001178525.3:1..1356" /experiment="EXISTENCE:direct assay:GO:0004026 alcohol O-acetyltransferase activity [PMID:16361250]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093|PMID:10515935]" /experiment="EXISTENCE:direct assay:GO:0017171 serine hydrolase activity [PMID:14645503]" /experiment="EXISTENCE:direct assay:GO:0034338 short-chain carboxylesterase activity [PMID:16361250]" /experiment="EXISTENCE:direct assay:GO:0051792 medium-chain fatty acid biosynthetic process [PMID:16361250]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:10515935]" /experiment="EXISTENCE:mutant phenotype:GO:0051792 medium-chain fatty acid biosynthetic process [PMID:16361250]" /experiment="EXISTENCE:mutant phenotype:GO:0051793 medium-chain fatty acid catabolic process [PMID:16361250]" /note="Octanoyl-CoA:ethanol acyltransferase; also functions as thioesterase; plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; localizes to lipid particles and the mitochondrial outer membrane; EHT1 has a paralog, EEB1, that arose from the whole genome duplication" /db_xref="GeneID:852476" /db_xref="SGD:S000000381" ORIGIN 1 msevskwpai npfhwgyngt vshivgengs iklhlkdnke qvdfdefank yvptlkngaq 61 fklspylftg ilqtlylgaa dfskkfpvfy greivkfsdg gvctadwlid swkkdyefdq 121 sttsfdkkkf dkdekathpe gwprlqprtr ylkdneleel revdlplvvi lhglaggshe 181 piirslaenl srsgrfqvvv lntrgcarsk ittrnlftay htmdireflq rekqrhpdrk 241 lyavgcsfga tmlanylgee gdksplsaaa tlcnpwdlll sairmsqdww srtlfsknia 301 qfltrtvqvn mgelgvpngs lpdhpptvkn psfymftpen likaksfkst refdevytap 361 algfpnamey ykaassinrv dtirvptlvi nsrddpvvgp dqpysivekn prilycrtdl 421 gghlayldkd nnswatkaia efftkfdelv v // LOCUS NP_009738 855 aa linear PLN 30-JUN-2025 DEFINITION mitofusin [Saccharomyces cerevisiae S288C]. ACCESSION NP_009738 VERSION NP_009738.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178527.1 REFERENCE 1 (residues 1 to 855) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 855) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 855) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 855) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 855) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 855) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 855) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07293. Method: conceptual translation. FEATURES Location/Qualifiers source 1..855 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..855 /product="mitofusin" /calculated_mol_wt="97677" Region 189..456 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site 194..201 /site_type="other" /note="G1 box" /db_xref="CDD:206648" Site order(196..202,316,370..371,373,408,409) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206648" Site 221 /site_type="other" /note="G2 box" /db_xref="CDD:206648" Site 225..227 /site_type="other" /note="Switch I region" /db_xref="CDD:206648" Site 313..316 /site_type="other" /note="G3 box" /db_xref="CDD:206648" Site order(315..316,335..336) /site_type="other" /note="Switch II region" /db_xref="CDD:206648" Site 370..373 /site_type="other" /note="G4 box" /db_xref="CDD:206648" CDS 1..855 /gene="FZO1" /locus_tag="YBR179C" /coded_by="NM_001178527.1:1..2568" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:19812251]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:9786948|PMID:9685359|PMID:11266460|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:38669296]" /experiment="EXISTENCE:direct assay:GO:0160189 peroxisomal-mitochondrial contact site [PMID:29720625]" /experiment="EXISTENCE:direct assay:GO:0160190 peroxisome-mitochondrion membrane tether activity [PMID:38669296]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:23341591]" /experiment="EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:23341591]" /experiment="EXISTENCE:mutant phenotype:GO:0008053 mitochondrial fusion [PMID:12808034|PMID:9786948]" /experiment="EXISTENCE:mutant phenotype:GO:0160190 peroxisome-mitochondrion membrane tether activity [PMID:29720625]" /experiment="EXISTENCE:physical interaction:GO:0008053 mitochondrial fusion [PMID:12808034]" /note="Mitofusin, involved in mitochondrial outer membrane fusion; mediates contacts between mitochondria and peroxisomes that regulate mitochondrial fusion; GTPase domain is required for auto-oligomerization and for efficient tethering, homotypic fusion and degradation of Fzo1p; role in mitochondrial genome maintenance; targeted for destruction by SCF-Mdm30p and the cytosolic ubiquitin-proteasome system; activity regulated by ubiquitination at conserved lysines and by deubiquitinases Ubp2p and Ubp12p" /db_xref="GeneID:852477" /db_xref="SGD:S000000383" ORIGIN 1 msegkqqfkd snkphkdstd qdddaativp qtltysrneg hflgsnfhgv tddrttlfdg 61 eegrreddll pslrssnska hlissqlsqw nynnnrvllk rsilktqafm dqlqeennir 121 pifiaander eklhvlqlni kldgqyntke kngfniekka lsklfhsqiv svtnhlnalk 181 krvddvsskv fitgdvntgk salcnsllkq rllpedqlpc tnvfseilea rendgieevh 241 aiplniaptl keaidmysiq npktyeihtl kelpdlvpqn gkyallkiyi kddkrpasts 301 llrngtvdis lidspglnmd slqtaevmsr qeeidlvifv vnaenqltls akefislasr 361 ekklmffvvk kfdkirdkqr ckelilkqir dlspetykra adfvhfvskn gdelphyhne 421 ndnedhgdrk pdddpysssd pdpdfdsled slrnfvlkkr slskllpakt ylskllsdii 481 misksnmkmy seeeikineq letlrpeils arakcndltt svdqmaeqti tmtynntkea 541 llnaldvplh eypkyqglgq iydfifstea fianqidesi gsselfakqk tdllvkkiye 601 igknelgddf mcervfrsel mfrkrkhlig krlkvslsit dlfaptwkgf lsylswqkpv 661 taplpdiegq tnegqiglmk ylglknyplt qywsrpsllf tskiptltly flgstkvvgn 721 iilngiklss wsslkklsvp vivvgsllgl tylihdlpra lpmnlsikyk rklqeldyih 781 lnaqrtsnev rdvlrvptre ilrsceiimd kkqitkkele nkkesnllsi kffqslyegt 841 vaqklmveei nldid // LOCUS NP_009739 572 aa linear PLN 30-JUN-2025 DEFINITION Dtr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009739 VERSION NP_009739.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178528.1 REFERENCE 1 (residues 1 to 572) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 572) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 572) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 572) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07294. Method: conceptual translation. FEATURES Location/Qualifiers source 1..572 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..572 /product="Dtr1p" /calculated_mol_wt="63276" Region 124..567 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(124,127..128,131,163,214..215,217..219,222,242, 245..246,249,375,378..379,382..384,387,411,415,488..489, 493,497,512,515..516,519..520,523) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..572 /gene="DTR1" /locus_tag="YBR180W" /coded_by="NM_001178528.1:1..1719" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:15755916|PMID:12455697]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005275 amine transmembrane transporter activity [PMID:12455697]" /experiment="EXISTENCE:mutant phenotype:GO:0015837 amine transport [PMID:12455697]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:12455697]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:12455697]" /note="Putative dityrosine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; required for spore wall synthesis; sequence similarity to QDR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expressed during sporulation" /db_xref="GeneID:852478" /db_xref="SGD:S000000384" ORIGIN 1 mgsepfqkkn lglqinsqes gttrstfhsl edlgddvine swdqvnqkra nidhdvfheh 61 pdsspslsaq kaktkeeeva vkssnsqsrd pspdtqahip ytyfskdqrl iifgiiifig 121 flgpmsgniy ipalpllqre ydvsattina tvsvfmavfs vgplfwgala dfggrkflym 181 vslslmlivn illaavpvni aalfvlrifq afasssvisl gagtvtdvvp pkhrgkaiay 241 fmmgpnmgpi iapivaglil mkgnywrwlf gftsimtgia lilvtallpe tlrcivgngd 301 pkwgdkkder ennespffeg nkishrrlfp digirkpvnn daffqenfpk ppkagltlyw 361 kmikcppiii tsvstallfs syyafsvtfs yylehdyrft mleigaayvc pgvamllgsq 421 sgghlsdylr srwikshpkk kfpaefrlll nligilltic gtigygwaif fhyhfvvllv 481 fsaltafgmt wcsntsmtyl telfpkraag tvavssffrn vgaaissaii lqlcnamgig 541 wcftglglcs sisligilyl lifqrkytak ef // LOCUS NP_009740 236 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS6 RPS6B [Saccharomyces cerevisiae S288C]. ACCESSION NP_009740 VERSION NP_009740.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178529.3 REFERENCE 1 (residues 1 to 236) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 236) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 236) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 236) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07295. On Jul 30, 2012 this sequence version replaced NP_009740.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..236 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..236 /product="40S ribosomal protein eS6 RPS6B" /calculated_mol_wt="26865" Region 1..220 /region_name="Ribosomal_S6e" /note="Ribosomal protein S6e; cl00931" /db_xref="CDD:469996" CDS 1..236 /gene="RPS6B" /locus_tag="YBR181C" /gene_synonym="LPG18; RPS101; RPS102" /coded_by="NM_001178529.3:1..711" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication" /db_xref="GeneID:852479" /db_xref="SGD:S000000385" ORIGIN 1 mklnisypvn gsqktfeidd ehrirvffdk rigqevdgea vgdefkgyvf kisggndkqg 61 fpmkqgvllp trikllltkn vscyrprrdg erkrksvrga ivgpdlavla lvivkkgeqe 121 legltdttvp krlgpkrann irkffglske ddvrdfvirr evtkgektyt kapkiqrlvt 181 pqrlqrkrhq ralkvrnaqa qreaaaeyaq llakrlserk aekaeirkrr asslka // LOCUS NP_009741 452 aa linear PLN 30-JUN-2025 DEFINITION Smp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009741 VERSION NP_009741.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178530.3 REFERENCE 1 (residues 1 to 452) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 452) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 452) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 452) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07296. On Jul 30, 2012 this sequence version replaced NP_009741.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..452 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..452 /product="Smp1p" /calculated_mol_wt="49283" Region 2..74 /region_name="MADS_MEF2_like" /note="MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...; cd00265" /db_xref="CDD:238165" Site order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,38) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238165" Site order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66, 69,72..73) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:238165" Site 59 /site_type="other" /note="putative phosphorylation site [posttranslational modification]" /db_xref="CDD:238165" Region 130..452 /region_name="ARG80" /note="Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]; COG5068" /db_xref="CDD:227400" CDS 1..452 /gene="SMP1" /locus_tag="YBR182C" /coded_by="NM_001178530.3:1..1359" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12482976]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12482976]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:10064699]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:9121433|PMID:19158363]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12482976]" /experiment="EXISTENCE:genetic interaction:GO:0071470 cellular response to osmotic stress [PMID:12482976]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12482976]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:12482976]" /note="MADS-box transcription factor involved in osmotic stress response; SMP1 has a paralog, RLM1, that arose from the whole genome duplication" /db_xref="GeneID:852480" /db_xref="SGD:S000000386" ORIGIN 1 mgrrkieiep ikddrnrtvt fikrkaglfk kahelsvlcq vdiaviilgs nntfyeyssv 61 dmsnllnvhq nntdlphnii epsdygdyvk kprvvlnerk rrrrratvlq pashsgsctv 121 ssqdsssvqn ngnlsaplas ndagnagvst plvhchgais rsgsnhsdca rnsadyqmlq 181 gglnsggsfh andykesvdq qhvaneaihr nfmnkrirpd thlllsesnh snyhnfypsp 241 yenlpkpslp aslvgnipsf qsqfvqvipa nsnpmgkgfn gtgdsesfea kqkihptvai 301 sntlegpapv qamvhhlhql nsnrgklsgk pylklnipka tndacqrspa mysgtaspkt 361 dvqatpnqml asnmssplsr skflgfknnd mddlyhngrc gstyvnnktf flkppigrpp 421 kfpkspsssi vvfpssvass tlkstsstns pd // LOCUS NP_878050 64 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR182C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878050 VERSION NP_878050.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184586.1 REFERENCE 1 (residues 1 to 64) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 64) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 64) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 64) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07297. Method: conceptual translation. FEATURES Location/Qualifiers source 1..64 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..64 /product="uncharacterized protein" /calculated_mol_wt="7248" CDS 1..64 /locus_tag="YBR182C-A" /coded_by="NM_001184586.1:1..195" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466446" /db_xref="SGD:S000028603" ORIGIN 1 mkiftlytmi qqyffdnggv ysiknfysav pkekmniilv sldcelqkla lklskktsgt 61 htth // LOCUS NP_009742 316 aa linear PLN 30-JUN-2025 DEFINITION phytoceramidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009742 VERSION NP_009742.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178531.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 316) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07298. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..316 /product="phytoceramidase" /calculated_mol_wt="36289" Region 18..286 /region_name="Ceramidase" /note="pfam05875" /db_xref="CDD:461766" CDS 1..316 /gene="YPC1" /locus_tag="YBR183W" /coded_by="NM_001178531.1:1..951" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10900202|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:24866405]" /experiment="EXISTENCE:genetic interaction:GO:0046513 ceramide biosynthetic process [PMID:11694577]" /experiment="EXISTENCE:genetic interaction:GO:0050291 sphingosine N-acyltransferase activity [PMID:11694577]" /experiment="EXISTENCE:mutant phenotype:GO:0017040 N-acylsphingosine amidohydrolase activity [PMID:10702247|PMID:10900202]" /experiment="EXISTENCE:mutant phenotype:GO:0046514 ceramide catabolic process [PMID:10702247]" /experiment="EXISTENCE:mutant phenotype:GO:0050291 sphingosine N-acyltransferase activity [PMID:10702247]" /note="Alkaline ceramidase; also has reverse (CoA-independent) ceramide synthase activity; catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance; YPC1 has a paralog, YDC1, that arose from the whole genome duplication" /db_xref="GeneID:852481" /db_xref="SGD:S000000387" ORIGIN 1 mgifrwnype ssvpgvwget tstidwceen yvvspyiaew sntltnsvfi lsaiyttysa 61 yknklekrfl ligfgyglvg vgswlfhmtl kyrfqlldel pmiyamcipt wslvceakea 121 llngdnhkkv plfeqifigv iiglavttas ilyviyknvd ihqilfgvqi vvvaatagsl 181 tyryvhdpla krnlkasmal gailflsgyi swlldihycs fwvhvrrsil alplgvllep 241 hgwwhiltgm giyfyivsle hlrvitlnvs cnyqfiwrwk vfpeliwkgr kpstryslel 301 fgpyvedqsi evkkek // LOCUS NP_009743 523 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR184W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009743 VERSION NP_009743.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178532.3 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 523) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07299. On Jul 30, 2012 this sequence version replaced NP_009743.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..523 /product="uncharacterized protein" /calculated_mol_wt="60512" CDS 1..523 /locus_tag="YBR184W" /coded_by="NM_001178532.3:1..1572" /note="hypothetical protein; YBR184W is not an essential gene" /db_xref="GeneID:852482" /db_xref="SGD:S000000388" ORIGIN 1 myqnnvlnai laseksnfqy dsgtilrnhk rpiitfnnni ehtvsepnnf tgyeekedld 61 imdicpyypk armladaiqh aktsasenkm elsmktipcl kkenvhvekg hdwsqlstsr 121 ickilediad kknktrrqsa plqktkyfpt nenqntdien qnwsqipned icaliekias 181 rrnknrkrkn lscskvqeiq gnidlpkkdv qegdisdssl faavrgtkkv sgydynsedk 241 ipnairlpyc kqilrlfsll qmkrndlivt sencnsgvff snfnyqlqvk sncianisst 301 lsflphheit vytsfilypn vvdniwectr yaiqllksea aqftllrdiy sgftiilsnh 361 ryhpkgfsad ycysaneltl flfvirtgqk kvlyrsiphn taaiekdssf dtenrkrrse 421 eevvlkcrkc snnslalkei styrldsaeg feksqplkde aklsdmnyvq gsisynrtil 481 tglwklfhrl cckdryrktn lsetlfydds terwvrmgel mhy // LOCUS NP_009744 278 aa linear PLN 30-JUN-2025 DEFINITION Mba1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009744 VERSION NP_009744.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178533.3 REFERENCE 1 (residues 1 to 278) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 278) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 278) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 278) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07300. On Jul 30, 2012 this sequence version replaced NP_009744.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..278 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..278 /product="Mba1p" /calculated_mol_wt="31680" Region 51..278 /region_name="MBA1" /note="MBA1-like protein; pfam07961" /db_xref="CDD:254545" CDS 1..278 /gene="MBA1" /locus_tag="YBR185C" /coded_by="NM_001178533.3:1..837" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11381092]" /experiment="EXISTENCE:direct assay:GO:0007007 inner mitochondrial membrane organization [PMID:11381092]" /experiment="EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:16601683]" /experiment="EXISTENCE:genetic interaction:GO:0070131 positive regulation of mitochondrial translation [PMID:20427570]" /experiment="EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:16601683]" /note="Membrane-associated mitoribosome receptor; involved along with Dpi29p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with nascent polypeptide chains; interacts with Mdm38p and may recruit mRNA-specific translational activators to the mitoribosome; null mutant displays decreased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane" /db_xref="GeneID:852483" /db_xref="SGD:S000000389" ORIGIN 1 msvlrstclf fpprsllisf nkrrlfstsr lilnkesett kkkdkskqqd fnprhlgvaa 61 eifipsaykn lpnvfahpli vanalirrly tfglnsvqva lfrfqsgikp sfllwknkai 121 etyinvntsf ahknlsdikg lvslwvqeal earsrqlpgn atldwqlikf navpklvsvq 181 pimipgmple hlqlvykfdt kqrlikvnqq tkktetldrd vvdyiaflcd attndmilmg 241 slfeskpndk lpksyeddak vaihrmkvng diyrlpps // LOCUS NP_009745 564 aa linear PLN 30-JUN-2025 DEFINITION Pch2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009745 VERSION NP_009745.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178534.1 REFERENCE 1 (residues 1 to 564) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 564) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 564) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 564) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07301. On Aug 9, 2000 this sequence version replaced NP_009745.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..564 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..564 /product="Pch2p" /calculated_mol_wt="63330" Region 248..465 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site order(319..321,354,356..357,398..399) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:410916" CDS 1..564 /gene="PCH2" /locus_tag="YBR186W" /coded_by="NM_001178534.1:1..1695" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11029058]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:24367111]" /experiment="EXISTENCE:genetic interaction:GO:0042138 meiotic DNA double-strand break formation [PMID:22745819]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:18305165]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:24367111]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:22745819]" /experiment="EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:22072981]" /note="Hexameric ring ATPase that remodels chromosome axis protein Hop1p; nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in rDNA; required for meiotic double-stranded break formation" /db_xref="GeneID:852484" /db_xref="SGD:S000000390" ORIGIN 1 msyivdlqvr gsslrvikcm fredeqissl hsgsdskqns nkklgeflnl lkavvkrkle 61 sfpkdrlkts iitgqelmre gqgsieikdp pteaqqhlir slakvllhqf ssingkvntv 121 negqdnlfls lfvkkisieq qstshvsikl nfhekinlgq hidsildsee tnesdtyhmg 181 svdefiiypf ccleeqdelk ngsilstefd kidleldedd gfegetlnnc insvgnfdip 241 lskqtlnlvn isylpgttfe gqweslyfgn nikerlysya tislkiarfk qtgdsnqedi 301 ttlitnnkll lvhgppgtgk ttlckalcqk lsvrrefsdg sdtidtnykg iiielscari 361 fskwfgessk nisivfkdie ellkvnegrg ificllidev eaiassrtnl ssrnestdgi 421 rvvntlltql drlkkyhnfl alatsnllds lddafvdrad gvfyvgnpta egilhilkvc 481 ieemitsgii lfharstgvk ffnkyqdilr kiaikcstvd isgrtirklp lmclseyfrt 541 fpvdddefvl alamsarkls aark // LOCUS NP_009746 280 aa linear PLN 30-JUN-2025 DEFINITION putative ribosome biosynthesis protein GDT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009746 VERSION NP_009746.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178535.1 REFERENCE 1 (residues 1 to 280) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 280) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 280) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 280) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07302. Method: conceptual translation. FEATURES Location/Qualifiers source 1..280 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..280 /product="putative ribosome biosynthesis protein GDT1" /calculated_mol_wt="30210" Region 39..277 /region_name="Gdt1" /note="Putative Ca2+/H+ antiporter, TMEM165/GDT1 family [General function prediction only]; COG2119" /db_xref="CDD:441722" CDS 1..280 /gene="GDT1" /locus_tag="YBR187W" /coded_by="NM_001178535.1:1..843" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005384 manganese ion transmembrane transporter activity [PMID:29632074]" /experiment="EXISTENCE:direct assay:GO:0005797 Golgi medial cisterna [PMID:23569283]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:23569283]" /experiment="EXISTENCE:direct assay:GO:0015085 calcium ion transmembrane transporter activity [PMID:27075443]" /experiment="EXISTENCE:direct assay:GO:0070588 calcium ion transmembrane transport [PMID:27075443]" /experiment="EXISTENCE:direct assay:GO:0071421 manganese ion transmembrane transport [PMID:29632074]" /experiment="EXISTENCE:genetic interaction:GO:0006874 intracellular calcium ion homeostasis [PMID:23569283]" /experiment="EXISTENCE:genetic interaction:GO:0030026 intracellular manganese ion homeostasis [PMID:29632074]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:23569283]" /experiment="EXISTENCE:mutant phenotype:GO:0030026 intracellular manganese ion homeostasis [PMID:29632074]" /experiment="EXISTENCE:mutant phenotype:GO:0032468 Golgi calcium ion homeostasis [PMID:27075443]" /note="Calcium and manganese transporter with higher affinity for Ca2+; involved in Ca2+ and Mn2+ homeostasis; localizes to the cis- and medial-Golgi apparatus; GFP-fusion localizes to the vacuole; required for the Mn2+-dependent function of glycosylation enzymes; TMEM165, a human ortholog linked to Congenital Disorders of Glycosylation, functionally complements the null allele; expression pattern and physical interactions suggest a possible role in ribosome biogenesis; expression regulated by Gcr1p" /db_xref="GeneID:852485" /db_xref="SGD:S000000391" ORIGIN 1 mgnmikkasl iallplftaa aaaatdaets mesgssshlk sflmsvsmig lseigdktfl 61 iaalmamrhk rvlvfsaaat slaimtilsg vvghsavafl serytaffag ilflvfgykl 121 tmeglemskd agveeemaev eeeiaikdmn qdmddvekgg dtaydkqlkn asigkkivhr 181 irelasfmfs pvwvqiflmv flgelgdrsq isiiamatds dywyviagav ighaicsgla 241 vvggkllatr isirtitlas sllffifalm yiyqafttqd // LOCUS NP_009747 140 aa linear PLN 30-JUN-2025 DEFINITION Ntc20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009747 VERSION NP_009747.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178536.3 REFERENCE 1 (residues 1 to 140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 140) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07303. On Jul 30, 2012 this sequence version replaced NP_009747.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..140 /product="Ntc20p" /calculated_mol_wt="15839" Region 3..127 /region_name="cwf18" /note="cwf18 pre-mRNA splicing factor; pfam08315" /db_xref="CDD:462423" CDS 1..140 /gene="NTC20" /locus_tag="YBR188C" /coded_by="NM_001178536.3:1..423" /experiment="EXISTENCE:curator inference:GO:0000384 first spliceosomal transesterification activity [PMID:11018040]" /experiment="EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:11018040]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:11018040]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:11018040]" /note="Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs" /db_xref="GeneID:852486" /db_xref="SGD:S000000392" ORIGIN 1 mpslrdlsle rdqelnqlra rinqlgktgk eeandfvgln isnepvydtv iqtgqssnat 61 nsfvqetiqk tkqkesgqpy iipqknehqr yidkvcetsd lkaklapime vlekktneki 121 kgiirkrvlq epdrdnddsg // LOCUS NP_009748 195 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS4 RPS9B [Saccharomyces cerevisiae S288C]. ACCESSION NP_009748 VERSION NP_009748.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178537.3 REFERENCE 1 (residues 1 to 195) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 195) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 195) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 195) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07304. On Jul 30, 2012 this sequence version replaced NP_009748.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..195 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..195 /product="40S ribosomal protein uS4 RPS9B" /calculated_mol_wt="22168" Region 1..180 /region_name="PTZ00155" /note="40S ribosomal protein S9; Provisional" /db_xref="CDD:185484" CDS 1..195 /gene="RPS9B" /locus_tag="YBR189W" /gene_synonym="RPS13A; SUP46" /coded_by="NM_001178537.3:1..588" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0045903 positive regulation of translational fidelity [PMID:6273576|PMID:7031259|PMID:7031258|PMID:3522920]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9B has a paralog, RPS9A, that arose from the whole genome duplication" /db_xref="GeneID:852487" /db_xref="SGD:S000000393" ORIGIN 1 mpraprtysk tystpkrpye ssrldaelkl agefglknkr eiyrisfqls kirraardll 61 trdekdpkrl fegnalirrl vrvgvlsedk kkldyvlalk vedflerrlq tqvyklglak 121 svhharvlit qrhiavgkqi vnipsfmvrl dsekhidfap tspfggarpg rvarrnaark 181 aeasgeaaee aedee // LOCUS NP_009750 160 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL21 RPL21A [Saccharomyces cerevisiae S288C]. ACCESSION NP_009750 VERSION NP_009750.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178539.1 REFERENCE 1 (residues 1 to 160) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 160) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 160) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07305. Method: conceptual translation. FEATURES Location/Qualifiers source 1..160 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..160 /product="60S ribosomal protein eL21 RPL21A" /calculated_mol_wt="18111" Region 1..157 /region_name="PTZ00189" /note="60S ribosomal protein L21; Provisional" /db_xref="CDD:240309" CDS 1..160 /gene="RPL21A" /locus_tag="YBR191W" /gene_synonym="URP1" /coded_by="NM_001178539.1:1..483" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication" /db_xref="GeneID:852489" /db_xref="SGD:S000000395" ORIGIN 1 mgkshgyrsr trymfqrdfr khgavhlsty lkvykvgdiv dikangsiqk gmphkfyqgk 61 tgvvynvtks svgviinkmv gnrylekrln lrvehikhsk crqeflervk anaakraeak 121 aqgvavqlkr qpaqpresri vstegnvpqt lapvpyetfi // LOCUS NP_009751 377 aa linear PLN 30-JUN-2025 DEFINITION Rim2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009751 VERSION NP_009751.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178540.1 REFERENCE 1 (residues 1 to 377) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 377) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 377) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 377) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07306. Method: conceptual translation. FEATURES Location/Qualifiers source 1..377 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..377 /product="Rim2p" /calculated_mol_wt="41971" Region <72..264 /region_name="PTZ00169" /note="ADP/ATP transporter on adenylate translocase; Provisional" /db_xref="CDD:240302" Region 294..377 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..377 /gene="RIM2" /locus_tag="YBR192W" /gene_synonym="PYT1" /coded_by="NM_001178540.1:1..1134" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:7891656|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006864 pyrimidine nucleotide transport [PMID:16194150]" /experiment="EXISTENCE:direct assay:GO:0015218 pyrimidine nucleotide transmembrane transporter activity [PMID:16194150]" /experiment="EXISTENCE:direct assay:GO:0030001 metal ion transport [PMID:23800229]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:16194150]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:7891656]" /note="Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family" /db_xref="GeneID:852491" /db_xref="SGD:S000000396" ORIGIN 1 mpkksieewe edaiesvpyl asdekgsnyk eatqiplnlk qseienhptv kpwvhfvagg 61 iggmagavvt cpfdlvktrl qsdiflkayk sqavniskgs trpksinyvi qagthfketl 121 giignvykqe gfrslfkglg pnlvgvipar sinfftygtt kdmyakafnn gqetpmihlm 181 aaatagwata tatnpiwlik trvqldkagk tsvrqyknsw dclksvirne gftglykgls 241 asylgsvegi lqwllyeqmk rlikersiek fgyqaegtks tsekvkewcq rsgsaglakf 301 vasiatyphe vvrtrlrqtp kengkrkytg lvqsfkviik eeglfsmysg ltphlmrtvp 361 nsiimfgtwe ivirlls // LOCUS NP_009752 223 aa linear PLN 30-JUN-2025 DEFINITION RNA polymerase II mediator complex subunit MED8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009752 VERSION NP_009752.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178541.3 REFERENCE 1 (residues 1 to 223) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 223) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 223) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 223) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07307. On Jul 30, 2012 this sequence version replaced NP_009752.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..223 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..223 /product="RNA polymerase II mediator complex subunit MED8" /calculated_mol_wt="25137" Region 32..>127 /region_name="Med8" /note="Mediator of RNA polymerase II transcription complex subunit 8; pfam10232" /db_xref="CDD:463012" CDS 1..223 /gene="MED8" /locus_tag="YBR193C" /coded_by="NM_001178541.3:1..672" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15705057]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12054864]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:16964259]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:18381891]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:18381891]" /experiment="EXISTENCE:physical interaction:GO:0003714 transcription corepressor activity [PMID:16528100]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" /db_xref="GeneID:852492" /db_xref="SGD:S000000397" ORIGIN 1 msqstaslvp egnqgslqed vsfdfngvpg qaldavrmrl aqlthslrri rdemskaelp 61 qwytlqsqln vtlsqlvsvt stlqhfqetl dstvvyplpk fpttsheslv ttllrkknip 121 evdewmkyvr etsgvttall kdeeiekllq qdreitnwar ttfrneygkh dfkneeslse 181 ehasllvrds kpskpfnvdd vlkftftgek piitgststs ssn // LOCUS NP_009753 123 aa linear PLN 30-JUN-2025 DEFINITION Aim4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009753 VERSION NP_009753.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178542.3 REFERENCE 1 (residues 1 to 123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 123) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07308. On Jul 30, 2012 this sequence version replaced NP_009753.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..123 /product="Aim4p" /calculated_mol_wt="14103" Region 73..122 /region_name="NpwBP" /note="mRNA biogenesis factor; pfam12622" /db_xref="CDD:403727" CDS 1..123 /gene="AIM4" /locus_tag="YBR194W" /gene_synonym="SOY1" /coded_by="NM_001178542.3:1..372" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /note="Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress" /db_xref="GeneID:852493" /db_xref="SGD:S000000398" ORIGIN 1 mdqkkdpsnn lterrvskvq rpnkkkvrnq veslsrnler nkegqllqtv skghleadsg 61 hslgrekeng elgirsifyd kdwnprgtap shyrnipynp atfkrrtevq arlgnlenik 121 ipk // LOCUS NP_009754 422 aa linear PLN 30-JUN-2025 DEFINITION Msi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009754 VERSION NP_009754.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178543.1 REFERENCE 1 (residues 1 to 422) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 422) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 422) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 422) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07309. Method: conceptual translation. FEATURES Location/Qualifiers source 1..422 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..422 /product="Msi1p" /calculated_mol_wt="47234" Region 21..88 /region_name="CAF1C_H4-bd" /note="Histone-binding protein RBBP4 or subunit C of CAF1 complex; pfam12265" /db_xref="CDD:463513" Region 133..173 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <142..422 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 203..247 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 255..292 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 299..338 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 343..381 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 387..412 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..422 /gene="MSI1" /locus_tag="YBR195C" /gene_synonym="CAC3" /coded_by="NM_001178543.1:1..1269" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11238915]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11238915]" /experiment="EXISTENCE:direct assay:GO:0006335 DNA replication-dependent chromatin assembly [PMID:9030687]" /experiment="EXISTENCE:direct assay:GO:0033186 CAF-1 complex [PMID:9030687]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:16503640]" /note="Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase" /db_xref="GeneID:852494" /db_xref="SGD:S000000399" ORIGIN 1 mnqcakdith eassipidlq eryshwkknt kllydylntn stkwpsltcq ffpdldttsd 61 ehrillssft ssqkpedeti yiskistlgh ikwsslnnfd mdemefkpen strfpskhlv 121 ndisiffpng ecnrarylpq npdiiagass dgaiyifdrt khgstrirqs kishpfetkl 181 fgshgviqdv eamdtssadi neatslawnl qqealllssh sngqvqvwdi kqyshenpii 241 dlplvsinsd gtavndvtwm pthdslfaac tegnavslld lrtkkeklqs nrekhdggvn 301 scrfnyknsl ilasadsngr lnlwdirnmn kspiatmehg tsvstlewsp nfdtvlatag 361 qedglvklwd tsceetifth gghmlgvndi swdahdpwlm csvandnsvh iwkpagnlvg 421 hs // LOCUS NP_009755 554 aa linear PLN 30-JUN-2025 DEFINITION glucose-6-phosphate isomerase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009755 VERSION NP_009755.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178544.1 REFERENCE 1 (residues 1 to 554) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 554) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 554) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07310. Method: conceptual translation. FEATURES Location/Qualifiers source 1..554 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..554 /product="glucose-6-phosphate isomerase" /EC_number="5.3.1.9" /calculated_mol_wt="61168" Region 12..553 /region_name="pgi" /note="glucose-6-phosphate isomerase; Reviewed; PRK00179" /db_xref="CDD:234679" CDS 1..554 /gene="PGI1" /locus_tag="YBR196C" /gene_synonym="CDC30" /coded_by="NM_001178544.1:1..1665" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:mutant phenotype:GO:0004347 glucose-6-phosphate isomerase activity [PMID:3007940]" /experiment="EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:3020369]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:3007940]" /note="Glycolytic enzyme phosphoglucose isomerase; catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation" /db_xref="GeneID:852495" /db_xref="SGD:S000000400" ORIGIN 1 msnnsftnfk latelpawsk lqkiyesqgk tlsvkqefqk dakrfeklnk tftnydgski 61 lfdysknlvn deiiaaliel akeanvtglr damfkgehin stedravyhv alrnrankpm 121 yvdgvnvape vdsvlkhmke fseqvrsgew kgytgkkitd vvnigiggsd lgpvmvteal 181 khyagvldvh fvsnidgthi aetlkvvdpe ttlfliaskt fttaetitna ntaknwflsk 241 tgndpshiak hfaalstnet evakfgidtk nmfgfeswvg grysvwsaig lsvalyigyd 301 nfeaflkgae avdnhftqtp lednipllgg llsvwynnff gaqthlvapf dqylhrfpay 361 lqqlsmesng ksvtrgnvft dystgsilfg epatnaqhsf fqlvhqgtkl ipsdfilaaq 421 shnpienklh qkmlasnffa qaealmvgkd eeqvkaegat gglvphkvfs gnrpttsila 481 qkitpatlga liayyehvtf tegaiwnins fdqwgvelgk vlakvigkel dnsstisthd 541 astnglinqf kewm // LOCUS NP_878051 49 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR196C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878051 VERSION NP_878051.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184541.3 REFERENCE 1 (residues 1 to 49) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 49) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 49) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 49) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07311. On Jul 30, 2012 this sequence version replaced NP_878051.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..49 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..49 /product="uncharacterized protein" /calculated_mol_wt="6124" CDS 1..49 /locus_tag="YBR196C-A" /coded_by="NM_001184541.3:1..150" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:32034123]" /note="hypothetical protein; identified by fungal homology and RT-PCR; ORF emerged de novo in thymine-rich ancestral non-genic region, accumulated substantial changes under positive selection, and progressively increased its transmembrane propensity to give rise to a protein that integrates into the endoplasmic reticulum (ER) membrane while retaining potential for adaptive change" /db_xref="GeneID:1466447" /db_xref="SGD:S000028534" ORIGIN 1 msrvyiyplt vfyffaiems vfcyynwfyr rnfpylfrpi fpflivlis // LOCUS NP_878052 34 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR196C-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878052 VERSION NP_878052.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184643.3 REFERENCE 1 (residues 1 to 34) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 34) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 34) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 34) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07312. On Jul 30, 2012 this sequence version replaced NP_878052.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..34 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..34 /product="uncharacterized protein" /calculated_mol_wt="3794" CDS 1..34 /locus_tag="YBR196C-B" /coded_by="NM_001184643.3:1..105" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466448" /db_xref="SGD:S000028816" ORIGIN 1 mwvvlskeki llkkayyakt ilfsalvlrg vrge // LOCUS NP_009756 217 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR197C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009756 VERSION NP_009756.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178545.1 REFERENCE 1 (residues 1 to 217) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 217) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 217) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 217) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07313. Method: conceptual translation. FEATURES Location/Qualifiers source 1..217 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..217 /product="uncharacterized protein" /calculated_mol_wt="24072" Region 103..159 /region_name="DUF5315" /note="Disordered region of unknown function (DUF5315); pfam17242" /db_xref="CDD:435806" CDS 1..217 /locus_tag="YBR197C" /coded_by="NM_001178545.1:1..654" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication" /db_xref="GeneID:852496" /db_xref="SGD:S000000401" ORIGIN 1 mgvkqtppvq vkvsdadstn rrksssqegn pqlvqlkaks dkdkrkgssd stasimgssn 61 alptknlttp palnplttsi srgntayers vngsritmhs nlaptetqdv swseidtldd 121 vkkmakepiv ndgfprdfes nltqmrksha qllrlmrern qrlkyaklrs pphkdqhnsa 181 tnkdqepdev lhdpeialdg ekyvsqvvdt ikdvhrc // LOCUS NP_009757 798 aa linear PLN 30-JUN-2025 DEFINITION chromatin modification protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009757 VERSION NP_009757.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178546.1 REFERENCE 1 (residues 1 to 798) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 798) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 798) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 798) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 798) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 798) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 798) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07314. Method: conceptual translation. FEATURES Location/Qualifiers source 1..798 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..798 /product="chromatin modification protein" /calculated_mol_wt="88837" Region 55..88 /region_name="LisH" /note="Lissencephaly type-1-like homology motif; smart00667" /db_xref="CDD:128913" Region 147..277 /region_name="TFIID_NTD2" /note="WD40 associated region in TFIID subunit, NTD2 domain; pfam04494" /db_xref="CDD:461330" Site order(172..173,212,241..245,280) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:176269" Site order(211,214..215) /site_type="other" /note="Ca binding site [ion binding]" /db_xref="CDD:176269" Region <458..724 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 470..523 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 529..565 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 570..606 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 613..648 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 654..690 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 697..732 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..798 /gene="TAF5" /locus_tag="YBR198C" /gene_synonym="TAF90" /coded_by="NM_001178546.1:1..2397" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12600943]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:12138208|PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:11585915]" /note="Subunit (90 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification" /db_xref="GeneID:852497" /db_xref="SGD:S000000402" ORIGIN 1 msqkqstnqn qngthqpqpv knqrtnnaag ansgqqpqqq sqgqsqqqgr sngpfsasdl 61 nrivleylnk kgyhrteaml raesgrtltp qnkqspantk tgkfpeqssi ppnpgktakp 121 isnptnlssk rdaeggivss grleglnape nyiraysmlk nwvdssleiy kpelsyimyp 181 ifiylflnlv aknpvyarrf fdrfspdfkd fhgseinrlf svnsidhike nevasafqsh 241 kyritmsktt lnlllyflne nesiggslii svinqhldpn ivesvtarek ladgikvlsd 301 sengngkqnl emnsvpvklg pfpkdeefvk eietelkikd dqekqlnqqt agdnysgann 361 rtllqeykam nnekfkdntg dddkdkikdk iakdeekkes elkvdgekkd snlsspardi 421 lplppktald lkleiqkvke srdaikldnl qlalpsvcmy tfqntnkdms cldfsddcri 481 aaagfqdsyi kiwsldgssl nnpnialnnn dkdedptckt lvghsgtvys tsfspdnkyl 541 lsgsedktvr lwsmdthtal vsykghnhpv wdvsfsplgh yfatashdqt arlwscdhiy 601 plrifaghln dvdcvsfhpn gcyvftgssd ktcrmwdvst gdsvrlflgh tapvisiavc 661 pdgrwlstgs edgiinvwdi gtgkrlkqmr ghgknaiysl syskegnvli sggadhtvrv 721 wdlkkattep saepdepfig ylgdvtasin qdikeygrrr tviptsdlva sfytkktpvf 781 kvkfsrsnla laggafrp // LOCUS NP_009758 464 aa linear PLN 30-JUN-2025 DEFINITION putative mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009758 VERSION NP_009758.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178547.3 REFERENCE 1 (residues 1 to 464) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 464) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 464) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 464) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07315. On Jul 30, 2012 this sequence version replaced NP_009758.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..464 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..464 /product="putative mannosyltransferase" /calculated_mol_wt="54425" Region 10..464 /region_name="KTR1" /note="Mannosyltransferase [Carbohydrate transport and metabolism]; COG5020" /db_xref="CDD:227353" CDS 1..464 /gene="KTR4" /locus_tag="YBR199W" /coded_by="NM_001178547.3:1..1395" /experiment="EXISTENCE:direct assay:GO:0000030 mannosyltransferase activity [PMID:26296208]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Glycosyltransferase involved in protein glycosylation; transfers GDP-mannose to methyl-alpha-mannoside in vitro; member of the KRE2/MNT1 mannosyltransferase family of type II membrane proteins with a short cytoplasmic N-terminus, a membrane-spanning region and a highly conserved catalytic lumenal domain" /db_xref="GeneID:852498" /db_xref="SGD:S000000403" ORIGIN 1 mrflskrilk pvlsviilis iavtvvlyfl tanenylqav kdsaksqyas lresyksitg 61 ktesadelpd hdaevldsim drlheplyek dtfdpnevla enkqlyeefl lqeisepkvd 121 nlvrsgdpla gkakgtilsl vrnsdledii ssiqqleeey nknfgypytf lndeeftdef 181 kdgiksilpk drvvefgtig pdnwnmpdsi drerydqemd kmskeniqya evesyhnmcr 241 fyskefyhhp llskykyvwr lepnvnfyck inydvfqfmn kndkiygfvl nlydspqtie 301 tlwtstmdfv eehpnylnvn gafawlkdns qnpknydytq gystchfwtn feivdldflr 361 sepyekymqy leekggfyye rwgdapvrsl alalfadkss ihwfrdigyh htpytncptc 421 padsdrcngn cvpgkftpws dldnqncqat wirhsmseee lemy // LOCUS NP_009759 551 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol-3-phosphate-binding protein BEM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009759 VERSION NP_009759.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178548.3 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 551) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07316. On Jul 30, 2012 this sequence version replaced NP_009759.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..551 /product="phosphatidylinositol-3-phosphate-binding protein BEM1" /calculated_mol_wt="61474" Region 76..127 /region_name="SH3_Bem1p_1" /note="First Src Homology 3 domain of Bud emergence protein 1 and similar domains; cd11878" /db_xref="CDD:212811" Site order(81,86,88..89,107..108,110,119,121,123,125..126) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212811" Region 159..214 /region_name="SH3_Bem1p_2" /note="Second Src Homology 3 domain of Bud emergence protein 1 and similar domains; cd11879" /db_xref="CDD:212812" Site order(164,169,171..172,188,191..192,194,204,206,208, 210..211) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212812" Region 284..400 /region_name="PX_Bem1p" /note="The phosphoinositide binding Phox Homology domain of Bem1p; cd06890" /db_xref="CDD:132800" Site order(317..319,356..357,369) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:132800" Region 478..549 /region_name="PB1" /note="PB1 domain; smart00666" /db_xref="CDD:214770" Site order(480,482,488..490,506,545) /site_type="other" /note="PB1 interaction [polypeptide binding]" /db_xref="CDD:99716" Site order(480,482,489..491,506,510,545) /site_type="other" /note="PB1 interaction surface [polypeptide binding]" /db_xref="CDD:99716" Site order(482,510) /site_type="other" /note="PB1 interaction surface [polypeptide binding]" /db_xref="CDD:99716" Site order(524,535) /site_type="other" /note="PB1 interaction site [polypeptide binding]" /db_xref="CDD:99716" Site order(524,535) /site_type="other" /note="PB1 interaction site [polypeptide binding]" /db_xref="CDD:99716" Site order(524,535) /site_type="other" /note="PB1 interaction surface [polypeptide binding]" /db_xref="CDD:99716" Site order(524,535) /site_type="other" /note="PB1 interaction surface [polypeptide binding]" /db_xref="CDD:99716" CDS 1..551 /gene="BEM1" /locus_tag="YBR200W" /gene_synonym="SRO1" /coded_by="NM_001178548.3:1..1656" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11927541|PMID:9128251]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11927541]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11927541]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11927541]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11927541]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:23613772]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:10087263]" /experiment="EXISTENCE:mutant phenotype:GO:0045185 maintenance of protein location [PMID:11927541]" /experiment="EXISTENCE:mutant phenotype:GO:0061191 positive regulation of vacuole fusion, non-autophagic [PMID:16854988]" /experiment="EXISTENCE:physical interaction:GO:0060090 molecular adaptor activity [PMID:11113154]" /note="Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p" /db_xref="GeneID:852499" /db_xref="SGD:S000000404" ORIGIN 1 mlknfklskr dsngskgrit sadistpshd ngsvikhikt vpvrylssss tpvksqrdss 61 pknrhnskdi tspekvikak ysyqaqtske lsfmegeffy vsgdekdwyk asnpstgkeg 121 vvpktyfevf drtkpssvng snsssrkvtn dslnmgslya ivlydfkaek adelttyvge 181 nlficahhnc ewfiakpigr lggpglvpvg fvsiidiatg yatgndvied iksvnlptvq 241 ewksniaryk asnislgsve qqqqqsitkp qnksaklvdg ellvkasves fgledekywf 301 lvccelsngk trqlkryyqd fydlqvqlld afpaeagklr daggqwskri mpyipgpvpy 361 vtnsitkkrk edlniyvadl vnlpdyisrs emvhslfvvl nngfdrefer denqnniktl 421 qendtatfat asqtsnfast nqdntltged lklnkklsdl slsgskqapa qstsglkttk 481 ikfyykddif almlkgdtty kelrskiapr idtdnfklqt klfdgsgeei ktdsqvsnii 541 qaklkisvhd i // LOCUS NP_878053 54 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR200W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878053 VERSION NP_878053.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184542.1 REFERENCE 1 (residues 1 to 54) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 54) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 54) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 54) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07317. Method: conceptual translation. FEATURES Location/Qualifiers source 1..54 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..54 /product="uncharacterized protein" /calculated_mol_wt="6329" CDS 1..54 /locus_tag="YBR200W-A" /coded_by="NM_001184542.1:1..165" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466449" /db_xref="SGD:S000028535" ORIGIN 1 mllcfhmcqr imwlpfdlmk wrrfhcgavl vgtlslrnrs pkilslyfis drtg // LOCUS NP_009760 211 aa linear PLN 30-JUN-2025 DEFINITION derlin [Saccharomyces cerevisiae S288C]. ACCESSION NP_009760 VERSION NP_009760.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178549.1 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 211) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07318. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..211 /product="derlin" /calculated_mol_wt="24260" Region 12..>192 /region_name="Rhomboid" /note="Rhomboid family; cl21536" /db_xref="CDD:451297" CDS 1..211 /gene="DER1" /locus_tag="YBR201W" /coded_by="NM_001178549.1:1..636" /experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8631297]" /experiment="EXISTENCE:direct assay:GO:0051787 misfolded protein binding [PMID:24292014]" /experiment="EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:24292014]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:23363603|PMID:8631297]" /experiment="EXISTENCE:mutant phenotype:GO:0070843 misfolded protein transport [PMID:24292014]" /experiment="EXISTENCE:physical interaction:GO:0036503 ERAD pathway [PMID:16619026]" /note="ER membrane protein that promotes export of misfolded polypeptides; required for ER-associated protein degradation of misfolded or unassembled proteins; initiates export of aberrant polypeptides from ER lumen by threading them into ER membrane and routing them to Hrd1p for ubiquitination; function normally requires N-terminal acetylation by NatB; N- and C- termini protrude into cytoplasm; similar to Dfm1p; homolog of mammalian derlin-1" /db_xref="GeneID:852500" /db_xref="SGD:S000000405" ORIGIN 1 mdavilnllg diplvtrlwt igclvlsglt slrivdpgkv vysydlvfkk gqygrllysi 61 fdygafnwis minifvsanh lstlensfnl rrkfcwiifl llvilvkmts ieqpaaslgv 121 llhenlvyye lkkngnqmnv rffgaidvsp sifpiymnav myfvykrswl eiamnfmpgh 181 viyymddiig kiygidlcks pydwfrntet p // LOCUS NP_001032571 67 aa linear PLN 30-JUN-2025 DEFINITION Min7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032571 VERSION NP_001032571.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184676.3 REFERENCE 1 (residues 1 to 67) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 67) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 67) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 67) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07319. On Jul 30, 2012 this sequence version replaced NP_001032571.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..67 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..67 /product="Min7p" /calculated_mol_wt="7587" CDS 1..67 /gene="MIN7" /locus_tag="YBR201C-A" /coded_by="NM_001184676.3:1..204" /note="Mitochondrial hypothetical protein" /db_xref="GeneID:3799967" /db_xref="SGD:S000087085" ORIGIN 1 mlamksfsqv sksykasaps kklttlfyva yitlglttpf llparmaskd thyykdefcs 61 qrsytrf // LOCUS NP_009761 845 aa linear PLN 30-JUN-2025 DEFINITION DNA replication licensing factor MCM7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009761 VERSION NP_009761.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178550.4 REFERENCE 1 (residues 1 to 845) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 845) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 845) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 845) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 845) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 845) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 845) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07320. On Jul 30, 2012 this sequence version replaced NP_009761.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..845 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..845 /product="DNA replication licensing factor MCM7" /EC_number="3.6.4.12" /calculated_mol_wt="94812" Region 59..138 /region_name="MCM_N" /note="MCM N-terminal domain; pfam14551" /db_xref="CDD:464206" Region 223..724 /region_name="MCM" /note="minichromosome maintenance proteins; smart00350" /db_xref="CDD:214631" Site order(421,446..448,462,467..468,471,475,482,484,486,488, 491..492,499,502,505..506,508,510,517,525,528,531,535, 538..539,542,547..551,554..555,557..558,560,572..573,589, 592,602,604,606,609..610,613,616..617,620..621,623,635, 651..654,657,661,664..665,668..669,685..687,693) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:350664" Site order(421..423,462..468,593,616,687) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350664" Site order(491,550..551) /site_type="other" /note="nucleic acid binding site [nucleotide binding]" /db_xref="CDD:350664" CDS 1..845 /gene="MCM7" /locus_tag="YBR202W" /gene_synonym="CDC47" /coded_by="NM_001178550.4:1..2538" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:15723534]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:9159120|PMID:9288745]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:11756674|PMID:16824194|PMID:9288745]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:12480933]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10704410|PMID:7708676]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:9335335|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10704410|PMID:7708676]" /experiment="EXISTENCE:direct assay:GO:0006260 DNA replication [PMID:15723534|PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0009378 four-way junction helicase activity [PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:18657510|PMID:15723534]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0042555 MCM complex [PMID:12480933]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:direct assay:GO:0097373 MCM core complex [PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:1904931 MCM complex binding [PMID:26912723]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:10783164|PMID:2044962]" /experiment="EXISTENCE:genetic interaction:GO:0006271 DNA strand elongation involved in DNA replication [PMID:10783164]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:17895243]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:10783164|PMID:2044962]" /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:10783164|PMID:10834843]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:19064704]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:19064704]" /experiment="EXISTENCE:mutant phenotype:GO:0033260 nuclear DNA replication [PMID:2044962]" /note="Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex" /db_xref="GeneID:852501" /db_xref="SGD:S000000406" ORIGIN 1 msaalpsiql pvdynnlfne itdflvtfkq dtlssdatrn enedenldae nieqhllekg 61 pkymamlqkv anrelnsvii dlddilqyqn ekflqgtqad dlvsaiqqna nhftelfcra 121 idnnmplptk eidykddvld vilnqrrlrn ermlsdrtne irsenlmdtt mdppssmnda 181 lrevvedete lfppnltrry flyfkplsqn carryrkkai sskplsvrqi kgdflgqlit 241 vrgiitrvsd vkpaveviay tcdqcgyevf qevnsrtftp lsectseecs qnqtkgqlfm 301 straskfsaf qeckiqelsq qvpvghiprs lnihvngtlv rslspgdivd vtgiflpapy 361 tgfkalkagl ltetyleaqf vrqhkkkfas fsltsdveer vmelitsgdv ynrlaksiap 421 eiygnldvkk alllllvggv dkrvgdgmki rgdinvclmg dpgvaksqll kaickisprg 481 vyttgkgssg vgltaavmkd pvtdemileg galvladngi ccidefdkmd esdrtaihev 541 meqqtisisk aginttlnar tsilaaanpl ygrynprlsp ldninlpaal lsrfdilflm 601 ldipsrddde klaehvtyvh mhnkqpdldf tpvepskmre yiayaktkrp vmseavndyv 661 vqayirlrqd skremdskfs fgqatprtll giirlsqala klrladmvdi ddveealrlv 721 rvskeslyqe tnkskedesp ttkiftiikk mlqetgkntl syenivktvr lrgftmlqls 781 nciqeysyln vwhlinegnt lkfvddgtmd tdqedslvst pklapqttas anvsaqdsdi 841 dlqda // LOCUS NP_009762 924 aa linear PLN 30-JUN-2025 DEFINITION Cos111p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009762 VERSION NP_009762.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178551.2 REFERENCE 1 (residues 1 to 924) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 924) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 924) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 924) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 924) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 924) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 924) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07321. On Apr 26, 2011 this sequence version replaced NP_009762.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..924 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..924 /product="Cos111p" /calculated_mol_wt="104484" Region 187..>222 /region_name="F-box_SF" /note="F-box domain superfamily; cl45894" /db_xref="CDD:459239" Site order(190..191,193..195,198..199,202,217..219,221) /site_type="other" /note="F-box motif" /db_xref="CDD:438852" Site order(190,194,197..198,201..202,210,212..213,217..219,221) /site_type="other" /note="Skp1 binding site [polypeptide binding]" /db_xref="CDD:438852" CDS 1..924 /gene="COS111" /locus_tag="YBR203W" /coded_by="NM_001178551.2:1..2775" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:12661761]" /note="Protein required for antifungal drug ciclopirox olamine resistance; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:852502" /db_xref="SGD:S000000407" ORIGIN 1 mssasrlqnv nivsnnysry gtsvydklyh sngsgsnnag knsttvgkls sisqksrskq 61 rhgsncsrsm sqsplstfks plsnqnqssa pddlasigqr rsddvtsldn etiitmnsrk 121 srikkkyksl istsskkfmn klydhgassd sfsifslkts hsgkhensrf eklrkrkyha 181 wgkfadindl pveiiakils efelgrdqkt lvrclyvskk fykatkivly rlpyftstyr 241 vaqfvtslrl hpdngayvkv ldlshlkpgi igqdskdsqg ldddghsrrh rrrrrrstnt 301 slnlppatpt stisneddan sglikddasn gsevedlala gwrdwryrne plysspllns 361 fklkkvvsrs ssitstssgn stgvhstrrq rsnssvasit tsimssiynt shvslsstts 421 ntsngnissg snlsrvstag slkkasakst rsspqkakpi sditssswfr mrlssrnrka 481 rtantinlkn skdksdddfk vlkhdsghps nyrsstlkfs ieqpfsthhp yankfllkya 541 pykdlplgyi lhmlnlcpnl velnlsnlvi ctdfklinqr serrrmtssl lpavqessvs 601 agpekdleiv ymtdsgkgye yyeglskkhs rssslgtnps swiggqanwt dypppidaqt 661 ktreehrrnn tlnnknvvlk klnpfeifem icnrneekgg ycsltkvkmn divwcrqymv 721 kyfvmrtfrq hldyksmenn syerhlfsfr dsgldrnfsw acnaklhefv almvmdhlsn 781 lddlgleelf nikseklyik nyccrdpdil eisnlfdiry gagseadats dsnleaeslq 841 frltilktek ptsfwltkvs kdyvslvvkl cvdddidmdk mkvgkptlri dsithnlisr 901 lkelrrvdlr rnvgennyya esii // LOCUS NP_009763 375 aa linear PLN 30-JUN-2025 DEFINITION triacylglycerol lipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009763 VERSION NP_009763.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178552.2 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 375) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07322. On Apr 26, 2011 this sequence version replaced NP_009763.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..375 /product="triacylglycerol lipase" /EC_number="3.1.1.3" /calculated_mol_wt="43156" Region 87..358 /region_name="Abhydrolase_1" /note="alpha/beta hydrolase fold; pfam00561" /db_xref="CDD:395444" CDS 1..375 /gene="LDH1" /locus_tag="YBR204C" /coded_by="NM_001178552.2:1..1128" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:21478434]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:21478430|PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0016788 hydrolase activity, acting on ester bonds [PMID:21478434]" /experiment="EXISTENCE:direct assay:GO:0017171 serine hydrolase activity [PMID:14645503]" /experiment="EXISTENCE:mutant phenotype:GO:0055088 lipid homeostasis [PMID:21478434]" /note="Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid droplet (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif)" /db_xref="GeneID:852503" /db_xref="SGD:S000000408" ORIGIN 1 mnmaeraeat kswsceplsg ktleeivqna enaadlvayi rkpevdldfr lkfiaeheef 61 fnvqlsdrns rirtchnlsd kgirgdtvfv fvpglagnle qfepllelvd sdqkafltld 121 lpgfghssew sdypmlkvve lifvlvcdvl rkwstavpnn dnvnpfnghk ivlvghsmgc 181 flachlyeqh madtkavqtl vlltppkahi eqlskdkhii qwalygvfkl pwlfdvyrnk 241 fdqvkglqss gikqyfyqqg ddvklkyrkf wqfknnisnk srtiigyllg wetvdwvkfn 301 gvltqtdmkq kiiifgaekd piapienlef ykqtinkecl rkviilpdcs hnlcfdrpel 361 vcenfqrevi dnskl // LOCUS NP_009764 404 aa linear PLN 30-JUN-2025 DEFINITION mannosyltransferase KTR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009764 VERSION NP_009764.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178553.3 REFERENCE 1 (residues 1 to 404) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 404) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 404) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 404) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07323. On Jul 30, 2012 this sequence version replaced NP_009764.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..404 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..404 /product="mannosyltransferase KTR3" /calculated_mol_wt="47351" Region 1..404 /region_name="KTR1" /note="Mannosyltransferase [Carbohydrate transport and metabolism]; COG5020" /db_xref="CDD:227353" CDS 1..404 /gene="KTR3" /locus_tag="YBR205W" /coded_by="NM_001178553.3:1..1215" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:genetic interaction:GO:0006491 N-glycan processing [PMID:9182588]" /experiment="EXISTENCE:genetic interaction:GO:0006493 protein O-linked glycosylation [PMID:9182588]" /experiment="EXISTENCE:mutant phenotype:GO:0000030 mannosyltransferase activity [PMID:9182588]" /note="Putative alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles; relocalizes from nucleus to vacuole upon DNA replication stress" /db_xref="GeneID:852504" /db_xref="SGD:S000000409" ORIGIN 1 msvhhkkklm pksallirky qkgirssfig liivlsflff msgsrspevp iaqgtsvsrv 61 askdylmpft dksqgvihpv ddgkkekgvm vtlarnsdlw nlvksirhve drfnnryhyd 121 wvflndqpfs defkrvtsal vsgkakygti pkdhwsipsw idtekfdekr lamgkldipy 181 gssvpyrhmc rfqsgfiwrh plleeyewfw rvdtditlfc diqydifkfl kvnnkkygfi 241 lsvseyerti ptlwettkkf ikknpkflhk nnlmkfisnd dgdtynmchf wtnfeigsld 301 ffrsdayrey fdyldssggf fyerwgdapv hsiaaslfld kseihffdgl gfhhpdftsc 361 pieqkirlqn kcicepskdv twtpdyfctr kyfsagnykl ppgi // LOCUS NP_009766 465 aa linear PLN 30-JUN-2025 DEFINITION Fth1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009766 VERSION NP_009766.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178555.4 REFERENCE 1 (residues 1 to 465) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 465) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 465) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 465) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07324. On Jul 30, 2012 this sequence version replaced NP_009766.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..465 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..465 /product="Fth1p" /calculated_mol_wt="51289" Region 129..404 /region_name="FTR1" /note="Iron permease FTR1 family; pfam03239" /db_xref="CDD:251822" CDS 1..465 /gene="FTH1" /locus_tag="YBR207W" /coded_by="NM_001178555.4:1..1398" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:10608875|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:genetic interaction:GO:0034755 iron ion transmembrane transport [PMID:10608875]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903]" /note="Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852506" /db_xref="SGD:S000000411" ORIGIN 1 mafedyfsfq iffiflresl eivvivsill tivkqglsve ddspfegsss saglpspntn 61 tnadsttafl qagpsdgnai gtsataannk srplnveeee eiyeysnelr dqdresdeht 121 adnvklyqkl kiqilaggaf glllcmligg afvsifyhig tdlwtlsehy yegvlslvas 181 viisvmglff lrmgklrekf rvklasiiys kdnnllgnkt qkgvkfseky sffilpfitt 241 lregleavvf iggigidqpl ssiplsmvla taistvfgif ffryssslsl kiclvvatcf 301 lyliaaglfs kgvwqlelqd yvnkcngqdm sevgngpgsy disrsvwhvn ccngekdggw 361 miftaifgwt nsatvgsvis ynaywlvlic alkllmieek ygyipylpis wqkkrimkrl 421 siakasldlk hhtselnsst sepdsqrrsk dssvpliids sgsan // LOCUS NP_009767 1835 aa linear PLN 30-JUN-2025 DEFINITION bifunctional urea carboxylase/allophanate hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009767 VERSION NP_009767.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178556.1 REFERENCE 1 (residues 1 to 1835) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1835) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1835) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1835) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07325. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1835 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1835 /product="bifunctional urea carboxylase/allophanate hydrolase" /EC_number="3.5.1.54" /EC_number="6.3.4.6" /calculated_mol_wt="201702" Region 49..620 /region_name="allophanate_hyd" /note="allophanate hydrolase; TIGR02713" /db_xref="CDD:274265" Region 633..1832 /region_name="urea_carbox" /note="urea carboxylase; TIGR02712" /db_xref="CDD:274264" CDS 1..1835 /gene="DUR12" /locus_tag="YBR208C" /gene_synonym="DUR80" /coded_by="NM_001178556.1:1..5508" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004039 allophanate hydrolase activity [PMID:6105114]" /experiment="EXISTENCE:mutant phenotype:GO:0004847 urea carboxylase activity [PMID:6105114]" /experiment="EXISTENCE:mutant phenotype:GO:0043419 urea catabolic process [PMID:6105114]" /note="Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852507" /db_xref="SGD:S000000412" ORIGIN 1 mtvssdttae islgwsiqdw idfhkssssq aslrllesll dsqnvapvdn awislisken 61 llhqfqilks renketlply gvpiavkdni dvrglpttaa cpsfayepsk dskvvellrn 121 agaiivgktn ldqfatglvg trspygktpc afskehvsgg ssagsasvva rgivpialgt 181 dtagsgrvpa alnnliglkp tkgvfscqgv vpacksldcv sifalnlsda ercfrimcqp 241 dpdndeysrp yvsnplkkfs snvtiaipkn ipwygetknp vlfsnavenl srtganviei 301 dfepllelar clyegtwvae ryqaiqsfld skppkesldp tvisiiegak kysavdcfsf 361 eykrqgilqk vrrllesvdv lcvptcplnp tmqqvadepv lvnsrqgtwt nfvnladlaa 421 lavpagfrdd glpngitlig kkftdyalle lanryfqnif pngsrtygtf tsssvkpand 481 qlvgpdydps tsiklavvga hlkglplhwq lekvnatylc ttktskayql falpkngpvl 541 kpglrrvqds ngsqielevy svpkelfgaf ismvpeplgi gsvelesgew iksficeesg 601 ykakgtvdit kyggfrayfe mlkkkesqkk klfdtvlian rgeiavriik tlkklgirsv 661 avysdpdkys qhvtdadvsv plhgttaaqt yldmnkiida akqtnaqaii pgygflsena 721 dfsdactsag itfvgpsgdi irglglkhsa rqiaqkagvp lvpgsllits veeakkvaae 781 leypvmvkst aggggiglqk vdseediehi fetvkhqget ffgdagvfle rfienarhve 841 vqlmgdgfgk aialgerdcs lqrrnqkvie etpapnlpek trlalrkaae slgsllnykc 901 agtvefiyde kkdefyflev ntrlqvehpi temvtgldlv ewmiriaand apdfdstkve 961 vngvsmearl yaenplknfr pspgllvdvk fpdwarvdtw vkkgtnispe ydptlakiiv 1021 hgkdrddais klnqaleetk vygcitnidy lksiitsdff akakvstnil nsyqyeptai 1081 eitlpgahts iqdypgrvgy wrigvppsgp mdaysfrlan rivgndyrtp aievtltgps 1141 ivfhcetvia itggtalctl dgqeipqhkp vevkrgstls igkltsgcra ylgirggidv 1201 pkylgsystf tlgnvggyng rvlklgdvlf lpsneenksv eclpqnipqs lipqisetke 1261 wrigvtcgph gspdffkpes ieeffsekwk vhynsnrfgv rligpkpkwa rsnggeggmh 1321 psnthdyvys lgainftgde pviitcdgps lggfvcqavv peaelwkvgq vkpgdsiqfv 1381 plsyessrsl kesqdvaiks ldgtklrrld svsilpsfet pilaqmekvn elspkvvyrq 1441 agdryvlvey gdnemnfnis yrieclislv kknktigive msqgvrsvli efdgykvtqk 1501 ellkvlvaye teiqfdenwk itsniirlpm afedsktlac vqryqetirs sapwlpnnvd 1561 fianvngisr nevydmlysa rfmvlglgdv flgspcavpl dprhrflgsk ynpsrtyter 1621 gavgiggmym ciyaanspgg yqlvgrtipi wdklclaass evpwlmnpfd qvefypvsee 1681 dldkmtedcd ngvykvniek svfdhqeylr winankdsit afqegqlger aeefakliqn 1741 anselkesvt vkpdeeedfp egaeivysey sgrfwksias vgdvieagqg lliieamkae 1801 miisapksgk iikichgngd mvdsgdivav ietla // LOCUS NP_001335746 105 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR209W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335746 VERSION NP_001335746.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348891.1 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 105) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80266. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..105 /product="uncharacterized protein" /calculated_mol_wt="11996" CDS 1..105 /locus_tag="YBR209W" /coded_by="NM_001348891.1:1..318" /note="hypothetical protein; conserved across S. cerevisiae strains; YBR209W is not an essential gene" /db_xref="GeneID:852508" /db_xref="SGD:S000000413" ORIGIN 1 mnaywfhyra sikkeapnyk rtflgrarna fllilseayl lfvflsylir gkslekrvnd 61 eakcsqrcvp lqlannlafg drhkrsanfk kgianthssl icskp // LOCUS NP_009769 142 aa linear PLN 30-JUN-2025 DEFINITION Erv15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009769 VERSION NP_009769.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178558.1 REFERENCE 1 (residues 1 to 142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 142) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07326. Method: conceptual translation. FEATURES Location/Qualifiers source 1..142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..142 /product="Erv15p" /calculated_mol_wt="16216" Region 8..120 /region_name="Cornichon" /note="Cornichon protein; pfam03311" /db_xref="CDD:460883" CDS 1..142 /gene="ERV15" /locus_tag="YBR210W" /coded_by="NM_001178558.1:1..429" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17298976]" /experiment="EXISTENCE:genetic interaction:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:17298976]" /note="Protein involved in export of proteins from the endoplasmic reticulum; ERV15 has a paralog, ERV14, that arose from the whole genome duplication" /db_xref="GeneID:852511" /db_xref="SGD:S000000414" ORIGIN 1 msgtglslfv tglilnclns icqiyftily gdleadyins ielckrvnrl svpeailqaf 61 isalflfngy wfvfllnvpv laynaskvyk kthlldatdi frklgrckie cflklgfyll 121 ifffyfyrmv tallendanl is // LOCUS NP_009770 324 aa linear PLN 30-JUN-2025 DEFINITION Ame1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009770 VERSION NP_009770.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178559.3 REFERENCE 1 (residues 1 to 324) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 324) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 324) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 324) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07327. On Jul 30, 2012 this sequence version replaced NP_009770.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..324 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..324 /product="Ame1p" /calculated_mol_wt="37331" CDS 1..324 /gene="AME1" /locus_tag="YBR211C" /gene_synonym="ARP100" /coded_by="NM_001178559.3:1..975" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0000817 COMA complex [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:14633972]" /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:19597337]" /experiment="EXISTENCE:physical interaction:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:14633972]" /note="Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:852512" /db_xref="SGD:S000000415" ORIGIN 1 mdrdtklafr lrgshsrrtd didddvivfk tpnavyreen spiqspvqpi lsspklansf 61 efpittnnvn aqdrhehgyq pldaedypmi dsenkslise spqnvrnded lttrynfddi 121 pirqlsssit svttidvlss lfinlfendl ipqalkdfnk sdddqfrkll ykldlrlfqt 181 isdqmtrdlk dildinvsnn elcyqlkqvl arkedlnqqi isvrneiqel kagkdwhdlq 241 neqaklndkv klnkrlndlt stllgkyegd rkimsqdsed dsirddsnil diahfvdlmd 301 pyngllkkin kinenlsnel qpsl // LOCUS NP_009771 672 aa linear PLN 30-JUN-2025 DEFINITION Ngr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009771 VERSION NP_009771.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178560.3 REFERENCE 1 (residues 1 to 672) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 672) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 672) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 672) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07328. On Jul 30, 2012 this sequence version replaced NP_009771.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..672 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..672 /product="Ngr1p" /calculated_mol_wt="74893" Region 35..180 /region_name="RRM1_NGR1_NAM8_like" /note="RNA recognition motif 1 (RRM1) found in yeast negative growth regulatory protein NGR1, yeast protein NAM8 and similar proteins; cd12611" /db_xref="CDD:410023" Region 191..270 /region_name="RRM2_NGR1_NAM8_like" /note="RNA recognition motif 2 (RRM2) found in yeast negative growth regulatory protein NGR1, yeast protein NAM8 and similar proteins; cd12613" /db_xref="CDD:410025" Region 359..430 /region_name="RRM3_NGR1_NAM8_like" /note="RNA recognition motif 3 (RRM3) found in yeast negative growth regulatory protein NGR1 (RBP1), yeast protein NAM8 and similar proteins; cd12346" /db_xref="CDD:409782" CDS 1..672 /gene="NGR1" /locus_tag="YBR212W" /gene_synonym="RBP1" /coded_by="NM_001178560.3:1..2019" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:16885161]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640|PMID:14570877]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:19470581|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:14570877]" /experiment="EXISTENCE:direct assay:GO:0061158 3'-UTR-mediated mRNA destabilization [PMID:14570877]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:14570877]" /experiment="EXISTENCE:mutant phenotype:GO:0061158 3'-UTR-mediated mRNA destabilization [PMID:14570877]" /note="RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay; expressed in stationary phase" /db_xref="GeneID:852513" /db_xref="SGD:S000000416" ORIGIN 1 mmsnvanasq rqenpyiipl ppsstvetst epprtlwmgd ldpsfdeati eeiwskldkk 61 vivklirakk nllipcssts ssnnntseen aenqqsasns tdqldnsqmi ningisfidp 121 sttqlhhagy cfvefetqkd akfalslnat plpnfysptt nsqtnptfkr tfrlnwasga 181 tlqssipstp efslfvgdls ptateadlls lfqtrfksvk tvrvmtdplt gssrcfgfvr 241 fgdederrra liemsgkwfq gralrvayat prnnmmlqlq eqqqqqqqlq qqhqqldqed 301 nngpllikta nnliqnnsnm lplnalhnap pmhlneggis nmrvndslps ntyntdptnt 361 tvfvgglvpk ttefqlrslf kpfgpilnvr ipngkncgfv kfekridaea siqglqgfiv 421 ggspirlswg rpsssnaktn stimgasqym ssnglrapsa assvdnskqi leqyaedkrr 481 lflhqqqqqq qqqqqdgnfs meqmahnnyy nynnydyhrn kngshsdlvn lqrsnvpymq 541 edgalyphqy sspsyslhpt gnqfsnatnn lpqfgnamsi smqlpngnsn ktassmntnp 601 ntnmimnsnm nmnmnvnpvp ygmgnganmy dvsrmmtppl niapnsnnsk ssimnkhpnr 661 nnvppihpsl lh // LOCUS NP_009772 274 aa linear PLN 30-JUN-2025 DEFINITION bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009772 VERSION NP_009772.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178561.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 274) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07329. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..274 /product="bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8" /EC_number="1.3.1.76" /EC_number="4.99.1.4" /calculated_mol_wt="31787" Region 7..213 /region_name="CysG2" /note="Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]; COG1648" /db_xref="CDD:441254" Region 193..249 /region_name="Sirohm_synth_C" /note="Sirohaem biosynthesis protein C-terminal; pfam14823" /db_xref="CDD:434243" CDS 1..274 /gene="MET8" /locus_tag="YBR213W" /coded_by="NM_001178561.1:1..825" /experiment="EXISTENCE:direct assay:GO:0004325 ferrochelatase activity [PMID:11980703]" /experiment="EXISTENCE:direct assay:GO:0043115 precorrin-2 dehydrogenase activity [PMID:11980703|PMID:10051442]" /experiment="EXISTENCE:mutant phenotype:GO:0000103 sulfate assimilation [PMID:10051442]" /experiment="EXISTENCE:mutant phenotype:GO:0019354 siroheme biosynthetic process [PMID:9003798]" /note="Bifunctional dehydrogenase and ferrochelatase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis" /db_xref="GeneID:852514" /db_xref="SGD:S000000417" ORIGIN 1 mvkslqlahq lkdkkillig ggevgltrly kliptgcklt lvspdlhksi ipkfgkfiqn 61 edqpdyreda krfinpnwdp tkneiyeyir sdfkdeyldl edendawyii mtcipdhpes 121 ariyhlcker fgkqqlvnva dkpdlcdfyf ganleigdrl qilistngls prfgalvrde 181 irnlftqmgd laledavvkl gelrrgirll apddkdvkyr mdwarrctdl fgiqhchnid 241 vkrlldlfkv mfqeqncslq fpprerllse ycss // LOCUS NP_009773 527 aa linear PLN 30-JUN-2025 DEFINITION Sds24p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009773 VERSION NP_009773.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178562.1 REFERENCE 1 (residues 1 to 527) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 527) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 527) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 527) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07330. Method: conceptual translation. FEATURES Location/Qualifiers source 1..527 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..527 /product="Sds24p" /calculated_mol_wt="57056" Region <188..331 /region_name="COG2524" /note="Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription]" /db_xref="CDD:442013" Region 287..396 /region_name="COG3448" /note="CBS-domain-containing membrane protein [Signal transduction mechanisms]" /db_xref="CDD:442671" CDS 1..527 /gene="SDS24" /locus_tag="YBR214W" /coded_by="NM_001178562.1:1..1584" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000920 septum digestion after cytokinesis [PMID:16041152]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903]" /note="Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication" /db_xref="GeneID:852515" /db_xref="SGD:S000000418" ORIGIN 1 mastsntfpp sqsnssnnlp tsrhasivem lstppllphv qvndtddkeq peestpptat 61 aaapgpgcaa tpaplrdekp qfklsavpmt qtpsqclscv haqkwqhipl sqlieqnkli 121 fvpgsisvee afntlikyhl nsipvesfpg dmncftfdyn dlnsylllvl nkitvsnkql 181 tadcqngkpv pvgemvkltp knpfyklpen eslstvmgil gsgvhrvait neemtkvkgi 241 lsqrrlikyl wdnarsftsl epllnsslqd lhigvlniqs kptsrqsrvi siqgeeplim 301 glykmhveri ssiavidkqg nllgnisvtd vkhvtrtsqy pllhktcrhf isvilnsrgl 361 etgkdsfpif hvypssslar tlaklvatks hrlwivqppe sstsasstnl taantaanav 421 sataqssang atpmskssss tslnshsplm tamedppspr ssaiaippps passtntpnl 481 fekeyrtgkl igvvsltdii nllarkqtgn kevdpqsarr qrgsiam // LOCUS NP_009774 625 aa linear PLN 30-JUN-2025 DEFINITION Hpc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009774 VERSION NP_009774.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178563.3 REFERENCE 1 (residues 1 to 625) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 625) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 625) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 625) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07331. On Jul 30, 2012 this sequence version replaced NP_009774.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..625 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..625 /product="Hpc2p" /calculated_mol_wt="67644" Region <569..601 /region_name="HUN" /note="HPC2 and ubinuclein domain; pfam08729" /db_xref="CDD:462581" CDS 1..625 /gene="HPC2" /locus_tag="YBR215W" /coded_by="NM_001178563.3:1..1878" /experiment="EXISTENCE:direct assay:GO:0000417 HIR complex [PMID:16264190|PMID:16303565]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16264190]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:16264190|PMID:16303565]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:16449659]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:1406694]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:1406694]" /experiment="EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:16264190]" /experiment="EXISTENCE:physical interaction:GO:0000417 HIR complex [PMID:16264190]" /note="Subunit of the HIR complex; HIR is a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes" /db_xref="GeneID:852516" /db_xref="SGD:S000000419" ORIGIN 1 mdqkaivldn sksgskqtks sgkmqtqtdt naevlntdns ikketgsdse dlfnkfsnkk 61 tnrkipniae elaknrnyvk gaspspiiis gssstspsgp sssstnpmgi ptnrfnkntv 121 elyqhspspv mttnktdtee krqnnrnmdn kntpergsss faakqlkiss lltissneds 181 ktlhindtng nknsnaasnn ipsayaelht egnsieslik ppssprnksl tpkvilptqn 241 mdgtiakdph lgdntpgili aktsspvnld vestaqslgk fnkstnslka altkapaekv 301 slkrsissvt nsdsnisssk kptsekakks ssasailpkp tttktskkaa snssdstrkk 361 nasnkttsai kkesnagskl ntvkkenssl ssikatekek dkggnsteak nstsnvrkep 421 takspkrlva aptvsppkil qtaetkakep silidvplyq adtndylden gqvifnlstl 481 ikekyhpksk elaqlkdskr nllmqlsdhs ngslekekde egdvielddd edmeedegei 541 dtetntvttt ispkkkshpm kgknligkyd vedpfiddse llweeqraat kdgffvyfgp 601 liekghyasl erangtmkrg gvknk // LOCUS NP_009775 674 aa linear PLN 30-JUN-2025 DEFINITION Ybp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009775 VERSION NP_009775.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178564.3 REFERENCE 1 (residues 1 to 674) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 674) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 674) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 674) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07332. On Jul 30, 2012 this sequence version replaced NP_009775.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..674 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..674 /product="Ybp1p" /calculated_mol_wt="77610" Region 1..669 /region_name="Kinetochor_Ybp2" /note="Uncharacterized protein family, YAP/Alf4/glomulin; pfam08568" /db_xref="CDD:400745" CDS 1..674 /gene="YBP1" /locus_tag="YBR216C" /coded_by="NM_001178564.3:1..2025" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0015035 protein-disulfide reductase activity [PMID:28628095]" /experiment="EXISTENCE:direct assay:GO:0065003 protein-containing complex assembly [PMID:28628095]" /experiment="EXISTENCE:direct assay:GO:0140297 DNA-binding transcription factor binding [PMID:28628095]" /experiment="EXISTENCE:mutant phenotype:GO:0018158 protein oxidation [PMID:28628095]" /note="Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication" /db_xref="GeneID:852517" /db_xref="SGD:S000000420" ORIGIN 1 mepiddilfe vtdafktqke dllelvtlid iygeqvnqeg syeektrfie tlntllednp 61 sttgeigwdl pkgllkflsk dnvdvngrlg tnmivqgvmk cfyaisiqge pkkclitgle 121 llsslcskdf sksdqqnked fvdkkantlp pegvienssn rkdfpsyges kssnefflkl 181 ksyilfefig aslkristlf pskylgaavs tiekfvysha dtfedalfll rrvytfcrny 241 ippdppkdiq lnedftremf dkvveeesel qvrllrrlct fgistpiktv ttnadvkyyc 301 alnqqkfels ayyteylelf cryyqmafsl dvdiegefqn vikecriiyk svpqeisavn 361 deaklvlerm vyklaytfev qkaakeknvg ldyngvilfs gihyletnqh lvkemnitda 421 iylylrfttp slyskvyynv avesvsrywl wyaitteple dvkkelknls vfvtktllhv 481 llqknciqvn qqlrmitftl ltrllclipe kvafefildv lktsplplak tsvlcvfkdl 541 srrristkdn dsetdlivek lsklkvndsn kaqqsnirhy iqldsskmka vhdcclqtiq 601 dsftadakks dilllltyln ifivlkktwd edllkivcsk idsnlksvep dklpkykeiv 661 dkneslndyf tgik // LOCUS NP_009776 186 aa linear PLN 30-JUN-2025 DEFINITION Atg12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009776 VERSION NP_009776.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178565.1 REFERENCE 1 (residues 1 to 186) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 186) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 186) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 186) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07333. Method: conceptual translation. FEATURES Location/Qualifiers source 1..186 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..186 /product="Atg12p" /calculated_mol_wt="20975" Region 103..186 /region_name="APG12" /note="Ubiquitin-like autophagy protein Apg12; pfam04110" /db_xref="CDD:397985" Site order(103,105..106,108,117,119,121..125,128,132..133, 136..137,139..140,142) /site_type="other" /note="Atg12; Atg5-Atg16-Atg3 interaction site [polypeptide binding]" /db_xref="CDD:340454" Site order(109,118) /site_type="other" /note="key conserved lysines" /db_xref="CDD:340454" Site order(154..155,157..161,164,167..169,185) /site_type="other" /note="Atg5 conjugation site [polypeptide binding]" /db_xref="CDD:340454" CDS 1..186 /gene="ATG12" /locus_tag="YBR217W" /gene_synonym="APG12" /coded_by="NM_001178565.1:1..561" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006501 C-terminal protein lipidation [PMID:17986448]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:23503366]" /experiment="EXISTENCE:direct assay:GO:0019776 Atg8-family ligase activity [PMID:17986448]" /experiment="EXISTENCE:direct assay:GO:0034274 Atg12-Atg5-Atg16 complex [PMID:11897782]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:16874032]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:9759731]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0061739 protein lipidation involved in autophagosome assembly [PMID:24485455]" /experiment="EXISTENCE:physical interaction:GO:0031386 protein tag activity [PMID:9759731|PMID:10508157|PMID:10233150]" /note="Ubiquitin-like modifier involved in autophagy and the Cvt pathway; conserved; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; homolog of mammalian ULK1" /db_xref="GeneID:852518" /db_xref="SGD:S000000421" ORIGIN 1 msrilesene tesdessiis tnngtamers rnnqelrssp htvqnrlelf srrlsqlgla 61 sdisvdqqve dsssgtyeqe etiktnaqts kqkshkdekn iqkiqikfqp igsigqlkps 121 vckismsqsf amvilflkrr lkmdhvycyi nnsfapspqq nigelwmqfk tndelivsyc 181 asvafg // LOCUS NP_009777 1180 aa linear PLN 30-JUN-2025 DEFINITION pyruvate carboxylase 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009777 VERSION NP_009777.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178566.1 REFERENCE 1 (residues 1 to 1180) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1180) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1180) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1180) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07334. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1180 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1180 /product="pyruvate carboxylase 2" /EC_number="6.4.1.1" /calculated_mol_wt="130036" Region 22..1170 /region_name="PRK12999" /note="pyruvate carboxylase; Reviewed; cl39082" /db_xref="CDD:476865" CDS 1..1180 /gene="PYC2" /locus_tag="YBR218C" /coded_by="NM_001178566.1:1..3543" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:2665820|PMID:196563]" /experiment="EXISTENCE:mutant phenotype:GO:0004736 pyruvate carboxylase activity [PMID:2039506]" /experiment="EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:8185321]" /note="Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc1p; mutations in the human homolog are associated with lactic acidosis; PYC2 has a paralog, PYC1, that arose from the whole genome duplication" /db_xref="GeneID:852519" /db_xref="SGD:S000000422" ORIGIN 1 mssskklagl rdnfsllgek nkilvanrge ipirifrsah elsmrtiaiy shedrlsmhr 61 lkadeayvig eegqytpvga ylamdeiiei akkhkvdfih pgygflsens efadkvvkag 121 itwigppaev idsvgdkvsa rhlaaranvp tvpgtpgpie tvqealdfvn eygypviika 181 afggggrgmr vvregddvad afqratsear tafgngtcfv erfldkpkhi evqlladnhg 241 nvvhlferdc svqrrhqkvv evapaktlpr evrdailtda vklakvcgyr nagtaeflvd 301 nqnrhyfiei npriqvehti teeitgidiv saqiqiaaga tltqlgllqd kittrgfsiq 361 crittedpsk nfqpdtgrle vyrsaggngv rldggnayag atisphydsm lvkcscsgst 421 yeivrrkmir aliefrirgv ktnipflltl ltnpvfiegt ywttfiddtp qlfqmvssqn 481 raqkllhyla dlavngssik gqiglpklks npsvphlhda qgnvinvtks appsgwrqvl 541 lekgpsefak qvrqfngtll mdttwrdahq sllatrvrth dlatiaptta halagafale 601 cwggatfdva mrflhedpwe rlrklrslvp nipfqmllrg angvaysslp dnaidhfvkq 661 akdngvdifr vfdalndleq lkvgvnavkk aggvveatvc ysgdmlqpgk kynldyylev 721 vekivqmgth ilgikdmagt mkpaaaklli gslrtrypdl pihvhshdsa gtavasmtac 781 alagadvvdv ainsmsglts qpsinallas legnidtgin vehvrelday waemrllysc 841 feadlkgpdp evyqheipgg qltnllfqaq qlglgeqwae tkrayreany llgdivkvtp 901 tskvvgdlaq fmvsnkltsd dirrlansld fpdsvmdffe gligqpyggf peplrsdvlr 961 nkrrkltcrp glelepfdle kiredlqnrf gdidecdvas ynmyprvyed fqkiretygd 1021 lsvlptknfl apaepdeeie vtieqgktli iklqavgdln kktgqrevyf elngelrkir 1081 vadksqniqs vakpkadvhd thqigapmag viievkvhkg slvkkgesia vlsamkmemv 1141 vsspadgqvk dvfikdgesv dasdllvvle eetlppsqkk // LOCUS NP_009778 127 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR219C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009778 VERSION NP_009778.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178567.3 REFERENCE 1 (residues 1 to 127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 127) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07335. On Jul 30, 2012 this sequence version replaced NP_009778.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..127 /product="uncharacterized protein" /calculated_mol_wt="14656" Region <1..100 /region_name="MFS" /note="Major Facilitator Superfamily; cl28910" /db_xref="CDD:475125" CDS 1..127 /locus_tag="YBR219C" /coded_by="NM_001178567.3:1..384" /note="hypothetical protein; YBR219C is not an essential gene" /db_xref="GeneID:852520" /db_xref="SGD:S000000423" ORIGIN 1 mtllntlsnf ggtwprliim sminyftvyq ctipgtnkvy vthggsmqac tellngtvti 61 lrdgyyitnl icivvglfly fgylkrkilh lqslpisswr ffhffftila vtsraiyyks 121 qnwrrec // LOCUS NP_009779 560 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR220C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009779 VERSION NP_009779.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178568.3 REFERENCE 1 (residues 1 to 560) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 560) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 560) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 560) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07336. On Jul 30, 2012 this sequence version replaced NP_009779.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..560 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..560 /product="uncharacterized protein" /calculated_mol_wt="62879" Region 18..558 /region_name="Acatn" /note="Acetyl-coenzyme A transporter 1; pfam13000" /db_xref="CDD:372424" CDS 1..560 /locus_tag="YBR220C" /coded_by="NM_001178568.3:1..1683" /note="hypothetical protein; YBR220C is not an essential gene" /db_xref="GeneID:852521" /db_xref="SGD:S000000424" ORIGIN 1 mepkrksgsl akhdlpqfyl limlylaqgi pvglafgtvp fllkslaket sftslgifsm 61 atypyslkii wspivdslyn krigrrrswi ipvqfvsgfv lwalgwcisq giifdgvdda 121 fhnrgngtlh svsiknltww fgllvflcat qdiavdgwal tilskeslsy astaqtigln 181 igyfmsftif lslnssdfan kyfrnipldh gfislggymk fsgmlyivit iyiifctkek 241 pyveylpkve pintsdggsk pisieyddgd vvstqntssi kyiyrcfikv lklksvrsla 301 fihmiskfaf qcneaatnlk lleqgfkred lavtvlidlp feiifgyyvv kwssdkdpmi 361 rdnrrlrnst gtnkvikflv gdagvltpwl wgflgrlaaa vlgsyvvkqf pkdgeistgy 421 fclvifqhll gsfmntvqfi gisafhtrva dpvlggtymt llntlsnfgg twprliimsm 481 inyftvyqct ipgtnkvyvt hggsmqacte llngtvtilr dgyyitnlic ivvglflyfg 541 ylkrkilhlq slpisswrct // LOCUS NP_009780 366 aa linear PLN 30-JUN-2025 DEFINITION pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_009780 VERSION NP_009780.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178569.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 366) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07337. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..366 /product="pyruvate dehydrogenase (acetyl-transferring) subunit E1 beta" /EC_number="1.2.4.1" /calculated_mol_wt="39923" Region <6..362 /region_name="PRK11892" /note="pyruvate dehydrogenase subunit beta; Provisional" /db_xref="CDD:237011" CDS 1..366 /gene="PDB1" /locus_tag="YBR221C" /coded_by="NM_001178569.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006086 pyruvate decarboxylation to acetyl-CoA [PMID:7947791]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:direct assay:GO:0045254 pyruvate dehydrogenase complex [PMID:2007123]" /experiment="EXISTENCE:mutant phenotype:GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity [PMID:8433986]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:8433986]" /note="E1 beta subunit of the pyruvate dehydrogenase (PDH) complex; PDH is an evolutionarily conserved multi-protein complex found in mitochondria" /db_xref="GeneID:852522" /db_xref="SGD:S000000425" ORIGIN 1 mfsrlptsla rnvarrapts fvrpsaaaaa lrfsstktmt vrealnsama eeldrdddvf 61 ligeevaqyn gaykvskgll drfgerrvvd tpiteygftg lavgaalkgl kpivefmsfn 121 fsmqaidhvv nsaakthyms ggtqkcqmvf rgpngaavgv gaqhsqdfsp wygsipglkv 181 lvpysaedar gllkaairdp npvvflenel lygesfeise ealspeftlp ykakieregt 241 disivtytrn vqfsleaaei lqkkygvsae vinlrsirpl dteaiiktvk ktnhlitves 301 tfpsfgvgae ivaqvmesea fdyldapiqr vtgadvptpy akeledfafp dtptivkavk 361 evlsie // LOCUS NP_878054 34 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR221W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878054 VERSION NP_878054.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184644.1 REFERENCE 1 (residues 1 to 34) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 34) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 34) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 34) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07338. Method: conceptual translation. FEATURES Location/Qualifiers source 1..34 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..34 /product="uncharacterized protein" /calculated_mol_wt="3955" CDS 1..34 /locus_tag="YBR221W-A" /coded_by="NM_001184644.1:1..105" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466450" /db_xref="SGD:S000028817" ORIGIN 1 mfshfevsen rprkqprrkr islgmintvv sldr // LOCUS NP_009781 543 aa linear PLN 30-JUN-2025 DEFINITION Pcs60p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009781 VERSION NP_009781.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178570.3 REFERENCE 1 (residues 1 to 543) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 543) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 543) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 543) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07339. On Jul 30, 2012 this sequence version replaced NP_009781.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..543 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..543 /product="Pcs60p" /EC_number="6.2.1.8" /calculated_mol_wt="60358" Region 18..531 /region_name="FACL_fum10p_like" /note="Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; cd05926" /db_xref="CDD:341249" Site order(194,197..202,204..205) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341249" Site order(197,310..311,332..337,417,429,432,443,523) /site_type="other" /note="putative AMP binding site [chemical binding]" /db_xref="CDD:341249" Site order(197,237..238,285,287..288,291,310..311,332..337,417, 429,432,440..443,504) /site_type="active" /note="putative active site [active]" /db_xref="CDD:341249" Site order(237,287..288,291,310,440..442,498,504) /site_type="other" /note="putative CoA binding site [chemical binding]" /db_xref="CDD:341249" CDS 1..543 /gene="PCS60" /locus_tag="YBR222C" /gene_synonym="FAT2" /coded_by="NM_001178570.3:1..1632" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:8841414]" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:8841414]" /experiment="EXISTENCE:direct assay:GO:0033611 oxalate catabolic process [PMID:24291261]" /experiment="EXISTENCE:direct assay:GO:0050203 oxalate-CoA ligase activity [PMID:24291261]" /experiment="EXISTENCE:mutant phenotype:GO:0033611 oxalate catabolic process [PMID:24291261]" /experiment="EXISTENCE:mutant phenotype:GO:0050203 oxalate-CoA ligase activity [PMID:24291261]" /note="Oxalyl-CoA synthetase; capable of catalyzing conversion of oxalate to oxalyl-CoA; catalyzes first step in pathway of oxalate degradation that functions to protect yeast from inhibitory effects of oxalate; peroxisomal protein that binds mRNA; localizes to both peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid; similar to E. coli long chain acyl-CoA synthetase" /db_xref="GeneID:852523" /db_xref="SGD:S000000426" ORIGIN 1 mtsaatvtas fndtfsvsdn vavivpetdt qvtyrdlshm vghfqtmftn pnsplygavf 61 rqdtvaismr nglefivafl gatmdakiga plnpnykeke fnfylndlks kaicvpkgtt 121 klqsseilks astfgcfive lafdatrfrv eydiyspedn ykrviyrsln nakfvntnpv 181 kfpgfarssd valilhtsgt tstpktvpll hlnivrstln iantykltpl drsyvvmplf 241 hvhgligvll stfrtqgsvv vpdgfhpklf wdqfvkyncn wfscvptism imlnmpkpnp 301 fphirfirsc ssalapatfh klekefnapv leayamteas hqmtsnnlpp gkrkpgtvgq 361 pqgvtvvild dndnvlppgk vgevsirgen vtlgyannpk ankenftkre nyfrtgdqgy 421 fdpegflvlt grikelinrg gekispield gimlshpkid eavafgvpdd mygqvvqaai 481 vlkkgekmty eelvnflkkh lasfkiptkv yfvdklpkta tgkiqrrvia etfakssrnk 541 skl // LOCUS NP_009782 544 aa linear PLN 30-JUN-2025 DEFINITION tyrosyl-DNA phosphodiesterase 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009782 VERSION NP_009782.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178571.3 REFERENCE 1 (residues 1 to 544) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 544) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 544) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 544) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07340. On Jul 30, 2012 this sequence version replaced NP_009782.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..544 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..544 /product="tyrosyl-DNA phosphodiesterase 1" /calculated_mol_wt="62202" Region 83..529 /region_name="Tyr-DNA_phospho" /note="Tyrosyl-DNA phosphodiesterase; pfam06087" /db_xref="CDD:461824" CDS 1..544 /gene="TDP1" /locus_tag="YBR223C" /coded_by="NM_001178571.3:1..1635" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:29523818]" /experiment="EXISTENCE:direct assay:GO:0017005 3'-tyrosyl-DNA phosphodiesterase activity [PMID:10521354]" /experiment="EXISTENCE:direct assay:GO:0070260 5'-tyrosyl-DNA phosphodiesterase activity [PMID:16751265]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:10521354|PMID:16751265|PMID:15135727]" /note="Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II, including DNA-protein cross-links; mutations in the human homolog, TDP1, result in the neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN)" /db_xref="GeneID:852525" /db_xref="SGD:S000000427" ORIGIN 1 msretnfngt krkrsdvaek vaqrwksvry saemenmapv nsnndsddcv ivseskiidl 61 tnqeqdlser ietndtakga vfklmksdfy eredfmgeve dmitlkdifg tetlkrsilf 121 sfqyeldfll rqfhqnveni tivgqkgtim piearamdat lavilkkvkl ieitmppfas 181 hhtkliinfy dngeckiflp snnftsmetn lpqqvcwcsp llkigkeglp vpfkrsliey 241 lnsyhlkdid elitksveev nfaplselef vystpskfqs sgllsfynkl eklsagtsas 301 dtakhylcqt ssigtslsra rdenlwthlm iplftgimsp pakdtagrkk aeilptnsli 361 neysqrkikp yiifpteqef vtsplkwsss gwfhfqylqk ksyyemlrnk fkvfykqdpa 421 mvtrrrgttp ahskfymhca tnsagpcdas qvfkelewcl ytsanlsqta wgtvsrkprn 481 yeagvlyhsr rlantrkvtc rtftrdrrgc agnpthvavp ftlpvipydl aedecfclar 541 hend // LOCUS NP_009784 900 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR225W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009784 VERSION NP_009784.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178573.1 REFERENCE 1 (residues 1 to 900) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 900) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 900) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 900) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07341. Method: conceptual translation. FEATURES Location/Qualifiers source 1..900 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..900 /product="uncharacterized protein" /calculated_mol_wt="101106" Region <697..>765 /region_name="COG4627" /note="Predicted SAM-depedendent methyltransferase [General function prediction only]" /db_xref="CDD:443666" CDS 1..900 /locus_tag="YBR225W" /coded_by="NM_001178573.1:1..2703" /note="hypothetical protein; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components" /db_xref="GeneID:852526" /db_xref="SGD:S000000429" ORIGIN 1 mgsnkeakni dskndrglts itsnkisnlk ahdnhtssmi tehknadkek gkqekesrng 61 ttqssssves hspqvshhsd klssfdsplh lpnfrladdl fsnssrrssd saasssvskl 121 ksaqlskigl hhhhtsnnkh shrsgtptse vkanyspdps aprfivsnmv gngrgggglh 181 gatsnvvkkl hsrkkwdwnt lpasdsslli ktvsgnhnli nicidgefkq imydpnhnel 241 fnrmdlflsf nmdsspedsl ifakkrlrsy idfltkyles rkyafecypf nieniiniet 301 evkcfpsfdp lkdyseiesl iqlwlaqsqk fllqsnsfff ssevveelik rkpttrqhsn 361 ptisttsnki sdptlyiqql dieansprpv isdpldeidi llirplhktl ggwqlaydep 421 slniadfald lspwmidssd ndaqnknase iapeyltnlq nylprkgsra kivsdeqevi 481 elnssnasey mydcmnrkff tddakerisr nnfnqgveed plndqfassr slslpssgad 541 avkrkksptk atkksgfvnf fkrkhsqlas tshttspsvs psissssspk iqpqshissp 601 prtekaphvk sanqahqnew lenffcrtln nykeidlptq filpkevkrs snaqlqpede 661 pplsspissn sdnsfpnegl draksaaiyg keylklrlpf asdtipavic pwvwtslsyy 721 kwkallreiy rsiipggyal aivpdlrisn tyytgilgna daekannsse eflttkerdk 781 tfdamaidai nkglhihptk hltrtfkdvg ftgikssvls lktgdfktdm gflnefnsld 841 mwdymlrrql pdsscppkdt dpttlfkryv eehigkiddn agcfrtlyvv aqkpklpytk // LOCUS NP_009786 520 aa linear PLN 30-JUN-2025 DEFINITION Mcx1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009786 VERSION NP_009786.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178575.1 REFERENCE 1 (residues 1 to 520) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 520) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 520) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 520) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07342. Method: conceptual translation. FEATURES Location/Qualifiers source 1..520 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..520 /product="Mcx1p" /calculated_mol_wt="57815" Region 29..458 /region_name="ClpX" /note="ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones]; COG1219" /db_xref="CDD:440832" CDS 1..520 /gene="MCX1" /locus_tag="YBR227C" /coded_by="NM_001178575.1:1..1563" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:25957689]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:9827555]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:25957689]" /experiment="EXISTENCE:direct assay:GO:1904287 positive regulation of protein-pyridoxal-5-phosphate linkage [PMID:25957689]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:27398316]" /experiment="EXISTENCE:mutant phenotype:GO:0042026 protein refolding [PMID:16460754]" /note="Non-proteolytic ATPase of the AAA family; stimulates incorporation of the pyridoxal phosphate cofactor into Hem1p (5-aminolevulinic acid synthase); localized to the mitochondrial matrix; ortholog of vertebrate CLPX, which promotes erythropoiesis" /db_xref="GeneID:852528" /db_xref="SGD:S000000431" ORIGIN 1 mlksasqnff rayssrigry aatasgklaq srlsniptpk alkkfldeyi vgqeigkkvl 61 svavynhylr indkqkkgel qrqrelmere kiaddrdepi fsgnseskag wrnlqrqfnl 121 agrevdedle lsksnvlvvg psgsgktlla ttlakilnvp iaitdctqlt qagyigedve 181 vcierllvna efdvaraekg iivldeidkl akpaasigtk dvsgegvqqs llkiieghkv 241 eitvkrpvkh didgqknqtt tkkdevfvvd tsnilfmimg afvgldkhiv kriedmkkiq 301 kagesvessn skevekerak kfrfsntleq veldngkkvc aldlttptdl vsfglipeli 361 grvpiitalq plqrddlfhi lkepknalld qyeyifkqfg vrlcvtqkal kkvaqfalke 421 gtgarglrgi merlllnvny dcpgsniayv lideatvdsl qetehslasq vdvkyysgde 481 kdslirdvse edkklgvmle kelghsanih tptipkrslt // LOCUS NP_009787 304 aa linear PLN 30-JUN-2025 DEFINITION endonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_009787 VERSION NP_009787.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178576.3 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 304) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07343. On Jul 30, 2012 this sequence version replaced NP_009787.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..304 /product="endonuclease" /calculated_mol_wt="35726" Region 13..87 /region_name="GIY-YIG_SLX1" /note="Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its eukaryotic homologs; cd10455" /db_xref="CDD:198402" Site order(15..17,29..31) /site_type="other" /note="GIY-YIG motif/motif A" /db_xref="CDD:198402" Site order(17,29,31,39,43,82) /site_type="active" /note="putative active site [active]" /db_xref="CDD:198402" Site 82 /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:198402" CDS 1..304 /gene="SLX1" /locus_tag="YBR228W" /coded_by="NM_001178576.3:1..915" /experiment="EXISTENCE:direct assay:GO:0017108 5'-flap endonuclease activity [PMID:12832395]" /experiment="EXISTENCE:genetic interaction:GO:0006261 DNA-templated DNA replication [PMID:12832395]" /experiment="EXISTENCE:physical interaction:GO:0033557 Slx1-Slx4 complex [PMID:12832395]" /note="Endonuclease involved in DNA recombination and repair; subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p" /db_xref="GeneID:852529" /db_xref="SGD:S000000432" ORIGIN 1 msqkiqqhqf pdfyccyllq sinkrqsfyv gstpnpvrrl rqhngklavg gayrtkrdgs 61 rpwemimivr gfpskiaalq fehawqhgyq thyiaekdrv vkhkaggrtl hhkvalmkll 121 lkheffqrmn livevfnika wevwkqdkff ierdrfpini qinenaleep kektvdvlmd 181 hsdenlkvve avytkviene rnifetfekk lttgvvrcei cekeidytse eqnlkpfval 241 cnnkdcgcvn hlkclhryfl ddeqlmvgrr nliprggkcp kcdmfcdwtt lvkfstrmkl 301 ahgk // LOCUS NP_009788 954 aa linear PLN 30-JUN-2025 DEFINITION glucan 1,3-alpha-glucosidase ROT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009788 VERSION NP_009788.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178577.3 REFERENCE 1 (residues 1 to 954) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 954) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 954) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 954) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 954) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 954) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 954) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07344. On Jul 30, 2012 this sequence version replaced NP_009788.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..954 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..954 /product="glucan 1,3-alpha-glucosidase ROT2" /EC_number="3.2.1.207" /calculated_mol_wt="110135" Region 259..380 /region_name="GH31_N" /note="N-terminal domain of glycosyl hydrolase family 31 (GH31); cd14752" /db_xref="CDD:270212" Site 299 /site_type="active" /db_xref="CDD:270212" Region 380..850 /region_name="GH31_GANC_GANAB_alpha" /note="neutral alpha-glucosidase C, neutral alpha-glucosidase AB; cd06603" /db_xref="CDD:269889" Site order(425,537,598,611,614,647,672) /site_type="active" /note="putative active site [active]" /db_xref="CDD:269889" CDS 1..954 /gene="ROT2" /locus_tag="YBR229C" /gene_synonym="GLS2" /coded_by="NM_001178577.3:1..2865" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:16373354]" /experiment="EXISTENCE:genetic interaction:GO:0070880 fungal-type cell wall beta-glucan biosynthetic process [PMID:9430631]" /experiment="EXISTENCE:mutant phenotype:GO:0006491 N-glycan processing [PMID:16373354]" /experiment="EXISTENCE:mutant phenotype:GO:0033919 glucan 1,3-alpha-glucosidase activity [PMID:16373354]" /experiment="EXISTENCE:mutant phenotype:GO:0106407 Glc2Man9GlcNAc2 oligosaccharide glucosidase activity [PMID:8910335]" /experiment="EXISTENCE:physical interaction:GO:0017177 glucosidase II complex [PMID:16373354]" /note="Glucosidase II catalytic subunit; required to trim the final glucose in N-linked glycans; required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations" /db_xref="GeneID:852530" /db_xref="SGD:S000000433" ORIGIN 1 mvllkwlvcq lvfftafsha ftdyllkkca qsgfchrnrv yaeniakshh cyykvdaesi 61 ahdplenvlh atiiktiprl egddiavqfp fslsflqdhs vrftineker mptnssglli 121 ssqrfnetwk yafdkkfqee anrtsipqfh flkqkqtvns fwskissfls lsnstadtfh 181 lrngdvsvei faepfqlkvy wqnalklivn eqnflniehh rtkqenfahv lpeettfnmf 241 kdnflyskhd smplgpesva ldfsfmgstn vygipehats lrlmdtsggk epyrlfnvdv 301 feynigtsqp mygsipfmfs ssstsifwvn aadtwvdiky dtsknktmth wisengvidv 361 vmslgpdipt iidkftdltg rpflppissi gyhqcrwnyn demdvltvds qmdahmipyd 421 fiwldleytn dkkyftwkqh sfpnpkrlls klkklgrnlv vlidphlkkd yeisdrvine 481 nvavkdhngn dyvghcwpgn siwidtisky gqkiwksffe rfmdlpadlt nlfiwndmne 541 psifdgpett apkdlihdny ieersvhniy glsvheatyd aiksiyspsd krpflltraf 601 fagsqrtaat wtgdnvanwd ylkisipmvl snniagmpfi gadiagfaed ptpeliarwy 661 qaglwypffr ahahidtkrr epylfneplk sivrdiiqlr yfllptlytm fhkssvtgfp 721 imnpmfiehp efaelyhidn qfywsnsgll vkpvtepgqs etemvfppgi fyefaslhsf 781 inngtdliek nisapldkip lfiegghiit mkdkyrrssm lmkndpyviv iapdtegrav 841 gdlyvddget fgyqrgeyve tqfifenntl knvrshipen ltgihhntlr ntniekiiia 901 knnlqhnitl kdsikvkkng eesslptrss yendnkitil nlslditedw evif // LOCUS NP_009789 134 aa linear PLN 30-JUN-2025 DEFINITION Om14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009789 VERSION NP_009789.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178578.1 REFERENCE 1 (residues 1 to 134) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 134) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 134) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 134) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07345. Method: conceptual translation. FEATURES Location/Qualifiers source 1..134 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..134 /product="Om14p" /calculated_mol_wt="14479" CDS 1..134 /gene="OM14" /locus_tag="YBR230C" /coded_by="NM_001178578.1:1..405" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936]" /experiment="EXISTENCE:direct assay:GO:1990593 nascent polypeptide-associated complex binding [PMID:25487825]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:25487825]" /experiment="EXISTENCE:mutant phenotype:GO:0033750 ribosome localization [PMID:25487825]" /experiment="EXISTENCE:physical interaction:GO:0044289 mitochondrial inner-outer membrane contact site [PMID:37073556]" /note="Mitochondrial outer membrane receptor for cytosolic ribosomes; integral protein of the outer membrane that interacts with the nascent chain-associated complex (NAC) bound to ribosomes, contributing to co-translational mitochondrial import; interacts with porin (Por1p) and Om45p; abundance is decreased in cells grown in glucose relative to other carbon sources" /db_xref="GeneID:852531" /db_xref="SGD:S000000434" ORIGIN 1 msatakhdsn aspnsdsedg hhhnnkkeca ieylkarlns asavacgylq afvsktqdfa 61 kvcflelqnp vvlvnlllhs svvcylcngy anhnarflkg kpnstvlatt agalglltld 121 giiskkyysr ydkk // LOCUS NP_001018029 66 aa linear PLN 30-JUN-2025 DEFINITION Coq21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001018029 VERSION NP_001018029.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184673.1 REFERENCE 1 (residues 1 to 66) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 66) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 66) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 66) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07346. Method: conceptual translation. FEATURES Location/Qualifiers source 1..66 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..66 /product="Coq21p" /calculated_mol_wt="7484" CDS 1..66 /gene="COQ21" /locus_tag="YBR230W-A" /coded_by="NM_001184673.1:1..201" /note="Mitochondrial hypothetical protein; YBR230W-A has a paralog, COQ8, that arose from the whole genome duplication" /db_xref="GeneID:2777172" /db_xref="SGD:S000029722" ORIGIN 1 mrnelyqlwc vasaargvak ssfvransam ceyvrtsnvl srwtrdrqwe aakalsqrvk 61 keyaan // LOCUS NP_009790 303 aa linear PLN 30-JUN-2025 DEFINITION Swc5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009790 VERSION NP_009790.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178579.3 REFERENCE 1 (residues 1 to 303) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 303) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 303) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 303) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07347. On Jul 30, 2012 this sequence version replaced NP_009790.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..303 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..303 /product="Swc5p" /calculated_mol_wt="34213" Region 14..79 /region_name="Swc5_NTD" /note="N-terminal domain of Saccharomyces cerevisiae SWR1-complex protein 5 (Swc5), and similar proteins; cd22868" /db_xref="CDD:439371" Site order(15..29,31) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:439371" Site 15..21 /site_type="other" /note="DEF/Y motif 1" /db_xref="CDD:439371" Site 23..29 /site_type="other" /note="DEF/Y motif 2" /db_xref="CDD:439371" Region 233..286 /region_name="BCNT" /note="Bucentaur or craniofacial development; pfam07572" /db_xref="CDD:462213" CDS 1..303 /gene="SWC5" /locus_tag="YBR231C" /gene_synonym="AOR1" /coded_by="NM_001178579.3:1..912" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14690608|PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /note="Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852532" /db_xref="SGD:S000000435" ORIGIN 1 mpevetkiip nekedededg yieeededfq pekdklgggs ddsdasdggd dyddgvnrdk 61 grnkvdysri esesgglikt rrarqaeeey akthkyeslt vesipakvns iweelqeask 121 nrllsssgkv gsvldgskea rsttaaqqed kiliernykf agetvhekkw vsrssaegqe 181 ylnslkfkqq apaapvqlek avrtksnesr qhlrrplkrp plleqiisgg lrpklttlek 241 sqldwasyvd raglndelvl hnkdgflarq eflqrvgsae derykelrrq qlaqqlqqds 301 eas // LOCUS NP_009792 413 aa linear PLN 30-JUN-2025 DEFINITION telomere maintenance protein PBP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009792 VERSION NP_009792.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178581.3 REFERENCE 1 (residues 1 to 413) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 413) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 413) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 413) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07348. On Jul 30, 2012 this sequence version replaced NP_009792.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..413 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..413 /product="telomere maintenance protein PBP2" /calculated_mol_wt="45651" Region 69..137 /region_name="KH-I_PCBP_rpt1" /note="first type I K homology (KH) RNA-binding domain found in the family of poly(C)-binding proteins (PCBPs); cd22438" /db_xref="CDD:411866" Site order(75,79..80,82..86,89,93,101..104,108,112) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:411866" Region 150..218 /region_name="KH-I_Rnc1_rpt2" /note="second type I K homology (KH) RNA-binding domain found in Schizosaccharomyces pombe RNA-binding protein Rnc1 and similar proteins; cd22456" /db_xref="CDD:411884" Site order(158,160..162,164..168,171..172,175..176,181..184) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:411884" Region 334..394 /region_name="KH-I" /note="K homology (KH) RNA-binding domain, type I; cd00105" /db_xref="CDD:411802" CDS 1..413 /gene="PBP2" /locus_tag="YBR233W" /gene_synonym="HEK1" /coded_by="NM_001178581.3:1..1242" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:15351640|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640|PMID:14562095|PMID:22842922|PMID:24390141]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:11739741]" /note="RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:852533" /db_xref="SGD:S000000437" ORIGIN 1 mstettkpsi tttpttvlvs pntlkrkkge dtseeqleae ikrvalkdad shsdndhdsp 61 dnvpsdvhlr mlclvkhasl ivghkgatis riksetsari nisnnirgvp erivyvrgtc 121 ddvakaygmi vralleehgn edngedieis inlliphhlm gciigkrgsr lreiedlsaa 181 klfaspnqll lsndriltin gvpdaihiat fyisqtllnf qmespqknvk rsiyyqptqf 241 nsvlidhsqp ntifhqrnhq yhpsdkllsy kpnknlpiss tllsmatpqy ttasvanata 301 fqpnfvipnv tvldgpvisp apgnhllmnf vqqeifidek fvgnvigkdg khinsvkest 361 gcsiiiqdpv egsserrlti rgtfmasqaa imlisnkiei drsnaerkrr spl // LOCUS NP_631876 94 aa linear PLN 30-JUN-2025 DEFINITION Dad3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_631876 VERSION NP_631876.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184461.1 REFERENCE 1 (residues 1 to 94) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 94) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 94) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 94) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07349. Method: conceptual translation. FEATURES Location/Qualifiers source 1..94 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..94 /product="Dad3p" /calculated_mol_wt="10717" Region 6..87 /region_name="DASH_Dad3" /note="DASH complex subunit Dad3; pfam08656" /db_xref="CDD:430136" CDS 1..94 /gene="DAD3" /locus_tag="YBR233W-A" /coded_by="NM_001184461.1:1..285" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15640796|PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]" /experiment="EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479468|PMID:20479465]" /note="Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" /db_xref="GeneID:852535" /db_xref="SGD:S000007595" ORIGIN 1 mehnlsplqq evldkykqls ldlkaldeti kelnysqhrq qhsqqetvsp deilqemrdi 61 evkiglvgtl lkgsvyslil qrkqeqeslg snsk // LOCUS NP_009793 384 aa linear PLN 30-JUN-2025 DEFINITION Arc40p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009793 VERSION NP_009793.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178582.1 REFERENCE 1 (residues 1 to 384) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 384) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 384) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 384) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07350. Method: conceptual translation. FEATURES Location/Qualifiers source 1..384 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..384 /product="Arc40p" /calculated_mol_wt="42344" Region <12..181 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 22..61 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 67..104 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 110..149 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 157..203 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 217..254 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 258..295 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..384 /gene="ARC40" /locus_tag="YBR234C" /coded_by="NM_001178582.1:1..1155" /experiment="EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:10377407|PMID:15485833]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:15485833]" /experiment="EXISTENCE:mutant phenotype:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:15485833]" /note="Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches" /db_xref="GeneID:852536" /db_xref="SGD:S000000438" ORIGIN 1 msfsnskdks vvavyklvka piyshcfsqd ksilavtcet dclvyrvsnn tppvlfatlk 61 dhdktitavd isihgrivtc sqdrnayvwe plsdgtykpt lvllrinraa tsvtwapngy 121 kfavgssari iavcyyehen nwwvskhikk pikstincls whangvllaa ggtdgfmrvf 181 sgfikgldsk esvagspwgq kfpfgclire wyqgsyihdv ewrsqmeria yvahdgtlnv 241 vdyqspvqsv napeglpyrs lvwindheiv cggyschpvl fseasegwkf aknldksdnn 301 kssaltasgn tdelsgnnde sstfgisalr kfkeldlkgk vstdvqesah enaivelrpf 361 aesngqitqv sscgldgkiv iyti // LOCUS NP_009794 1120 aa linear PLN 30-JUN-2025 DEFINITION Vhc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009794 VERSION NP_009794.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178583.3 REFERENCE 1 (residues 1 to 1120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1120) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07351. On Jul 30, 2012 this sequence version replaced NP_009794.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1120 /product="Vhc1p" /calculated_mol_wt="123868" Region 45..824 /region_name="AA_permease_2" /note="Amino acid permease; cl45918" /db_xref="CDD:459263" CDS 1..1120 /gene="VHC1" /locus_tag="YBR235W" /coded_by="NM_001178583.3:1..3363" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:23022132]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:genetic interaction:GO:0055075 potassium ion homeostasis [PMID:23022132]" /experiment="EXISTENCE:mutant phenotype:GO:0015379 potassium:chloride symporter activity [PMID:23022132]" /experiment="EXISTENCE:mutant phenotype:GO:0034486 vacuolar transmembrane transport [PMID:23022132]" /note="Vacuolar membrane cation-chloride cotransporter (CCC); involved in potassium homeostasis and salt tolerance; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family" /db_xref="GeneID:852537" /db_xref="SGD:S000000439" ORIGIN 1 mvsrfyqipg thrpssaiss snesssllsa rrisqtyfny qatpecqkvs skydpdnpnk 61 dklgtydgvf vptalnvlsi lmflrfgfil gqlgiictig llllsytinl lttlsisais 121 tngtvrggga yymisrslgp efggsiglvf flgqvfnagm navgiiepll ynlgysaqge 181 ppaalgellp rghwheftya tvilflcfsv afvgsqtvsr agnilflvla asifsiplsa 241 lirspftegg isytgpswqt fhdnllphlt kgaagsllkg ketfndlfgv ffpatagifa 301 gagmsselrk psksipkgtl wgllftficy avvvfsmgcs iprrslydev qiiqtissvq 361 wvifmgemat slfsiivgml gaayvleaia kdniipglei fahsplysli ftwiltqlcl 421 fsdvnkiatf itmtflmtfv vmnlacfllg issapnfrps fkyfnrytta igallsvvam 481 livdgisasv lflamillfl fihyfsppks wgdvsqsliy hqvrkyllrl rqdnikywrp 541 qillfvdnpr tswnlirfcn hlkkgglyil ghvavtadfp kqlnelktqq kawmkirdma 601 aikafvqvgt gpsliwgirn vfigsglggm kpnitvvgff dlesyrkhip qsrsqnnlqk 661 qveikatvpr stcsdvkinv plptdeckne tkvnvqqwvq ivedlslmqs niaiahgfkn 721 leipnkrdsc fpkktidlyp iqmcgkveak gdqpaaittn fdtytlilql aailvtvpew 781 krthslrvil fveqeyhrtn etqrmkkllq vlridaevlv vsldqfrvyn tivkgdpivf 841 dyvnskladn ewwkdlvear dtlkpkrrfs tiepqtiakq ftqsrkytsg vqklgvsftm 901 ntrmptnrid tpcesedsdl dtdltsirda fsastnisvg kdlttksktg sdrtnllvkn 961 lqsdvstqsl rpvfssntlp rtrvvedgtg eqptlipiae pdlsngngtg sgigngnklk 1021 kpvlpelspc cskdslvtam qnlgfndlps taqhlvlndv mtqmskssdl ifstlpvpal 1081 gthedhdasl qyvedldiwl eglppcmlin sqtmtvttal // LOCUS NP_009795 436 aa linear PLN 30-JUN-2025 DEFINITION mRNA (guanine-N7)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009795 VERSION NP_009795.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178584.3 REFERENCE 1 (residues 1 to 436) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 436) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 436) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 436) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07352. On Jul 30, 2012 this sequence version replaced NP_009795.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..436 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..436 /product="mRNA (guanine-N7)-methyltransferase" /EC_number="2.1.1.56" /calculated_mol_wt="50210" Region 109..424 /region_name="Pox_MCEL" /note="mRNA capping enzyme; pfam03291" /db_xref="CDD:281307" Site order(171..177,194..195,222..223,225,249) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..436 /gene="ABD1" /locus_tag="YBR236C" /coded_by="NM_001178584.3:1..1311" /experiment="EXISTENCE:direct assay:GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity [PMID:7623811]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006370 7-methylguanosine mRNA capping [PMID:7623811]" /note="Methyltransferase; catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA; nuclear protein that relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852538" /db_xref="SGD:S000000440" ORIGIN 1 mstkpekpiw msqedydrqy gsitgdesst vskkdskvta napgdgngsl pvlqsssilt 61 skvsdlpiea esgfkiqkrr herydqeerl rkqraqklre eqlkrheiem tanrsinvdq 121 ivrehynert iianrakrnl spiiklrnfn naikymlidk ytkpgdvvle lgcgkggdlr 181 kygaagisqf igidisnasi qeahkryrsm rnldyqvvli tgdcfgeslg vavepfpdcr 241 fpcdivstqf clhyafetee karrallnva kslkigghff gtipdsefir yklnkfpkev 301 ekpswgnsiy kvtfennsyq kndyeftspy gqmytywled aidnvpeyvv pfetlrslad 361 eyglelvsqm pfnkffvqei pkwierfspk mreglqrsdg rygvegdeke aasyfytmfa 421 frkvkqyiep esvkpn // LOCUS NP_009796 849 aa linear PLN 30-JUN-2025 DEFINITION DEAD-box RNA helicase PRP5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009796 VERSION NP_009796.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178585.1 REFERENCE 1 (residues 1 to 849) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 849) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 849) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 849) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07353. Method: conceptual translation. FEATURES Location/Qualifiers source 1..849 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..849 /product="DEAD-box RNA helicase PRP5" /EC_number="3.6.4.13" /calculated_mol_wt="96228" Region 244..468 /region_name="DEADc_DDX46" /note="DEAD-box helicase domain of DEAD box protein 46; cd17953" /db_xref="CDD:350711" Region 255..707 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" Site order(257,276,278..280,283,301..307,415..416) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350711" Region 749..837 /region_name="KH-I_PRP5_like" /note="type I K homology (KH) RNA-binding domain found in fungal pre-mRNA-processing ATP-dependent RNA helicase PRP5 and similar proteins; cd22474" /db_xref="CDD:411902" CDS 1..849 /gene="PRP5" /locus_tag="YBR237W" /gene_synonym="RNA5" /coded_by="NM_001178585.1:1..2550" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:8969184]" /experiment="EXISTENCE:mutant phenotype:GO:0000348 mRNA branch site recognition [PMID:8405998]" /note="RNA helicase in the DEAD-box family; necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA" /db_xref="GeneID:852539" /db_xref="SGD:S000000441" ORIGIN 1 metidskqni nreslleerr kklakwkqkk aqfdaqkehq tsrndivtns legkqttekf 61 terqervkee lrkrknefrk sdepvsvkps kkkskrskvk kkisfdfsdd ddseigvsfr 121 skehiqkape hdnekdplde fmtslkeekm snskgmydrg dildvedqlf elggtddedv 181 edntdnsnia kiaklkakkr vkqiyyspee lepfqknfyi esetvssmse meveelrlsl 241 dnikikgtgc pkpvtkwsql glstdtmvli teklhfgslt piqsqalpai msgrdvigis 301 ktgsgktisy llpllrqvka qrplskhetg pmglilaptr elalqiheev tkfteadtsi 361 rsvcctggse mkkqitdlkr gteivvatpg rfidiltlnd gkllstkrit fvvmdeadrl 421 fdlgfepqit qimktvrpdk qcvlfsatfp nklrsfavrv lhspisitin skgmvnenvk 481 qkfrichsed ekfdnlvqli herseffdev qsendgqssd veevdakaii fvssqnicdf 541 iskkllnagi vtcaihagkp yqerlmnlek fkreknsill ctevlsrgln vpevslviiy 601 navktfaqyv httgrtargs rsgtaitlll hdelsgayil skamrdeeik aldplqakel 661 qemsakfesg mkkgkfrlsk gfggkgleni kskreeaqnk dlelkkndkr sddlekkisn 721 preghdsvse ssaliprlny elfkestdgs iifyakvyin dlpqivrwea tknttllfik 781 hetgcsitnk gkfypegkep knendepkly lliegqdekd iqlsielleq kvkegvvkaa 841 slslkstky // LOCUS NP_009797 731 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR238C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009797 VERSION NP_009797.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178586.1 REFERENCE 1 (residues 1 to 731) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 731) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 731) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 731) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07354. Method: conceptual translation. FEATURES Location/Qualifiers source 1..731 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..731 /product="uncharacterized protein" /calculated_mol_wt="83630" CDS 1..731 /locus_tag="YBR238C" /coded_by="NM_001178586.1:1..2196" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:17194787]" /experiment="EXISTENCE:genetic interaction:GO:0009060 aerobic respiration [PMID:17194787]" /note="Mitochondrial membrane protein; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span; YBR238C has a paralog, RMD9, that arose from the whole genome duplication" /db_xref="GeneID:852540" /db_xref="SGD:S000000442" ORIGIN 1 mirlaqqtqv lkgkppnqfv phptknslth pmkfngtiam ehhehnyaip ytpatfnnpa 61 latyqvspan hfvphfggni gannnnhlaq nnsnnsnnhh nnnrnhhhnn nrnhhqnnhn 121 hskynnsnqg nsispdspwf hkvcafedcv sqtlymsqtp rrqnmkhhse hpnsnanplf 181 wdsigramgl yhdllttpel nsdrvsklvh llhnglranr nqltrmnkkp dydsqsfhke 241 mtnylckslr eisedvlngk velneygamh litafkelll feeavdiwka aingqntyts 301 niflnprvvg vilpilydng vsypeiqaly eksssminyf hpnlsvgmir aslsasendm 361 alklfqklcq estemkygyl iethlsfige ckdlnvaqtf fdkalndemp ykidlqvsyv 421 ksflrniwsq trdfnhiyqi wyksslhygr nvnhgisssl ndtffdiffe nyavdkmqgf 481 qtlqniiqty nnikhidepf fniilakctv whdrsileyi dksyeayhip ktivayrill 541 ksmgsvddas naeilqrwmd lirksdeigq rfianadwaa lrdatvtwtq ndrdskksnm 601 nstqisrtat pspsltpmdt papehlfnnp qnpmdfyshp alqaatasga fdefaaeaas 661 ssipvdgrmv lylkivkrys pycrdsrqla rlttgtavky svlqevlnqf qtlivndipi 721 pelhnlkptc v // LOCUS NP_009798 529 aa linear PLN 30-JUN-2025 DEFINITION Ert1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009798 VERSION NP_009798.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178587.3 REFERENCE 1 (residues 1 to 529) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 529) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 529) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 529) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07355. On Jul 30, 2012 this sequence version replaced NP_009798.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..529 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..529 /product="Ert1p" /calculated_mol_wt="60180" Region 36..69 /region_name="GAL4" /note="GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6)motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations; cd00067" /db_xref="CDD:238023" Site order(39,44..47,49,51,61) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(40,43,50,56,59,68) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 411..527 /region_name="PAS" /note="PAS fold; pfam00989" /db_xref="CDD:395786" CDS 1..529 /gene="ERT1" /locus_tag="YBR239C" /coded_by="NM_001178587.3:1..1590" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363|PMID:25123508|PMID:19111667]" /experiment="EXISTENCE:genetic interaction:GO:0045722 positive regulation of gluconeogenesis [PMID:25123508]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:25123508]" /experiment="EXISTENCE:genetic interaction:GO:0045991 carbon catabolite activation of transcription [PMID:25123508]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:25123508]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:25123508]" /experiment="EXISTENCE:mutant phenotype:GO:0045013 carbon catabolite repression of transcription [PMID:25123508]" /note="Transcriptional regulator; involved in regulation of gluconeogenesis and fermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition; member of the zinc cluster family of proteins, similar to Rds2p" /db_xref="GeneID:852541" /db_xref="SGD:S000000443" ORIGIN 1 mctpdendyk tstdpdtsan tnhtlekkkr kkrkntnvac vncsrlhvsc eakrpclrci 61 skgltatcvd aprkkskyla gipnrelpmn iqpdlpprki mipiynnssn sslnvnnmge 121 qqkftspqhi vhkakflsna adseysilsn iiyqdtlsnk ipidilysnt nstsnstign 181 ssnnsptgtn tspeetemek irqlyseqra nipphpypss nqnvysillg pnsakivasq 241 vnlfanhfpl vpvdsadnsl nfkrllprdp sekssqinwd ssinqyylns etvtfpelai 301 plkrrknhlv svslescspd aaniksnvew ehslrystpm eiytsinapf shtpgfhhll 361 vylkhrfnqq dlvkmcrsia efrpifiacs vtlteedmif meqcyqrtll eyvkfiaqig 421 tptciwrrng qisyvneefe ilcgwtreel lnkmtfivei mddesvrdyf ktlskvayrd 481 frgsekmkvc rllspikgki ihcccmwtlk rdvsglplmi lgnfmpiln // LOCUS NP_009799 450 aa linear PLN 30-JUN-2025 DEFINITION Thi2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009799 VERSION NP_009799.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178588.3 REFERENCE 1 (residues 1 to 450) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 450) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 450) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 450) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07356. On Jul 30, 2012 this sequence version replaced NP_009799.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..450 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..450 /product="Thi2p" /calculated_mol_wt="51692" Site order(25,29,34..37,39,42,52) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Region 28..66 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(30,33,40,47,50,57) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..450 /gene="THI2" /locus_tag="YBR240C" /gene_synonym="PHO6" /coded_by="NM_001178588.3:1..1353" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:22404710]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16194233]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:19013460]" /experiment="EXISTENCE:mutant phenotype:GO:0090180 positive regulation of thiamine biosynthetic process [PMID:1551422]" /note="Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type" /db_xref="GeneID:852542" /db_xref="SGD:S000000444" ORIGIN 1 mvnskrqqrs kkvassskvp ptkgrtftgc wacrfkkrrc denrpicslc akhgdncsyd 61 irlmwleeni ykvrkhslis slqarksksk plcqkisksr fkqmthfrql spptsdceds 121 vheaskettl pndntftisv rrlkiynnav asvfgsmtnr dytqkridkk ldellnmven 181 disvvnlncs khgpysvfra npaavtsalt dqlpspghsm ssaeetttaa lssppedsts 241 lidiiqgkif gilwfncygn milnrqeytt wfinkmrnsl ttefirflgk iiddpdinma 301 sclfkeciar wscvdwqsia itmlviihgy tcpnltkllr vwflqqkllr fsmyplvnfi 361 inntqdldvl yhcngllgna dlfedpyqde ltselhvlvt erlvnswkdt ilqqlcscqd 421 ttlscsqlry wqlqlkcnqq fykdvyamqd // LOCUS NP_009800 488 aa linear PLN 30-JUN-2025 DEFINITION Vvs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009800 VERSION NP_009800.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178589.1 REFERENCE 1 (residues 1 to 488) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 488) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 488) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 488) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 488) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 488) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 488) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07357. Method: conceptual translation. FEATURES Location/Qualifiers source 1..488 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..488 /product="Vvs1p" /calculated_mol_wt="53395" Region 28..478 /region_name="MFS_GLUT_Class1_2_like" /note="Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; cd17357" /db_xref="CDD:340915" Site order(38,42,180,183..184,187,307..308,312..313,316,342, 399..400,404,408,431,435) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340915" CDS 1..488 /gene="VVS1" /locus_tag="YBR241C" /coded_by="NM_001178589.1:1..1467" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23708375|PMID:14562095|PMID:26928762]" /note="Putative transporter, member of the sugar porter family; localizes to the vacuolar membrane; non-essential gene; upregulated by and required for tolerance to 4-Methylcyclohexane methanol; YBR241C has a paralog, VPS73, that arose from the whole genome duplication" /db_xref="GeneID:852543" /db_xref="SGD:S000000445" ORIGIN 1 maeterlmpn ggsretkpli tghlilgtiv aclgsiqygy hiaelnapqe flscsrfeap 61 denisyddtw vgqhglkqci altdsqygai tsifsigglf gsyyagnwan rygrkyvsmg 121 asamcmvssl llffsnsylq llfgrflvgm scgtaivitp lfineiapve wrgamgsmnq 181 vsinlgillt qtlalkyads ynwrwllfsg sviavanila wlkvdesprw lvshgfvsea 241 etalfklrpg tyqqakqeiq dwqrshghnr dpesseeths gptlwqyvtd psykkprtvi 301 lailscqqfc ginsiifygv kvigkilpdy siqvnfaisi lnvvvtlaas aiidhvgrrp 361 lllasttvmt amsllisvgl tlsvsfllvt atfvyiaafa iglgpipfli igelsypqda 421 ataqsfgtvc nwlatfivgy lfpighglmg gyvfaifaai aamfatyvyk rvpetkgktt 481 ysevwagy // LOCUS NP_009801 238 aa linear PLN 30-JUN-2025 DEFINITION 5'-deoxynucleotidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009801 VERSION NP_009801.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178590.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 238) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07358. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..238 /product="5'-deoxynucleotidase" /EC_number="3.1.3.89" /calculated_mol_wt="27446" Region 55..200 /region_name="HD_3" /note="HD domain; pfam13023" /db_xref="CDD:432939" Site 109 /site_type="other" /note="Mg2+ binding site [ion binding]" /db_xref="CDD:238032" CDS 1..238 /locus_tag="YBR242W" /coded_by="NM_001178590.1:1..717" /experiment="EXISTENCE:direct assay:GO:0002953 5'-deoxynucleotidase activity [PMID:29752939]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008253 5'-nucleotidase activity [PMID:29752939]" /experiment="EXISTENCE:direct assay:GO:0009159 deoxyribonucleoside monophosphate catabolic process [PMID:29752939]" /note="5'-deoxynucleotidase involved in deoxyribonucleoside monophosphate degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential gene; YBR242W has a paralog, YGL101W, that arose from the whole genome duplication" /db_xref="GeneID:852544" /db_xref="SGD:S000000446" ORIGIN 1 mtatitnkks csgsveagkt rlttewkpes qvpqyvknel skphpnyila flnvvqqlki 61 qrrtgyldlg ikecesisdh myrlsiitml ikdsrvnrdk cvrialvhdi aeslvgditp 121 vdpigkeekh rrewetikyl cnalikpyne iaakeimddw layenvtsle aryvkdidky 181 emlvqcfeye reykgtknfd dffgavasik tdevkgwtsd lvvqrqkyfa dltqsitk // LOCUS NP_009802 448 aa linear PLN 30-JUN-2025 DEFINITION UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009802 VERSION NP_009802.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178591.3 REFERENCE 1 (residues 1 to 448) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 448) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 448) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 448) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07359. On Jul 30, 2012 this sequence version replaced NP_009802.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..448 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..448 /product="UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase" /EC_number="2.7.8.15" /calculated_mol_wt="50237" Region 43..352 /region_name="GT_GPT_euk" /note="UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is...; cd06855" /db_xref="CDD:133465" Site 146..147 /site_type="other" /note="Mg++ binding site [ion binding]" /db_xref="CDD:133465" Site 284..287 /site_type="active" /note="putative catalytic motif [active]" /db_xref="CDD:133465" CDS 1..448 /gene="ALG7" /locus_tag="YBR243C" /gene_synonym="TUR1" /coded_by="NM_001178591.3:1..1347" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043541 UDP-N-acetylglucosamine transferase complex [PMID:19129246]" /experiment="EXISTENCE:mutant phenotype:GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity [PMID:6096695]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:15794922]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:15794922]" /note="UDP-N-acetyl-glucosamine-1-P transferase; transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin; human homolog DPAGT1 can complement yeast ALG7 mutant" /db_xref="GeneID:852545" /db_xref="SGD:S000000447" ORIGIN 1 mlrlfslali tcliyysknq gpsalvaavg fgiagylatd mliprvgksf ikiglfgkdl 61 skpgrpvlpe tigaipaavy lfvmfiyipf ifykymvitt sggghrdvsv vedngmnsni 121 fphdklseyl sailclestv llgiaddlfd lrwrhkfflp aiaaipllmv yyvdfgvthv 181 lipgfmerwl kktsvdlglw yyvymasmai fcpnsinila gvnglevgqc ivlailalln 241 dllyfsmgpl atrdshrfsa vliipflgvs lalwkwnrwp atvfvgdtyc yfagmvfavv 301 gilghfsktm lllfipqivn fiyscpqlfk lvpcprhrlp kfnekdglmy psranlkeep 361 pksifkpilk llyclhlidl efdenneiis tsnmtlinlt lvwfgpmred klcntilklq 421 fcigilallg rhaigaiifg hdnlwtvr // LOCUS NP_009803 162 aa linear PLN 30-JUN-2025 DEFINITION glutathione peroxidase GPX2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009803 VERSION NP_009803.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178592.3 REFERENCE 1 (residues 1 to 162) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 162) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 162) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 162) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07360. On Jul 30, 2012 this sequence version replaced NP_009803.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..162 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..162 /product="glutathione peroxidase GPX2" /EC_number="1.11.1.24" /calculated_mol_wt="18275" Region 2..160 /region_name="BtuE" /note="Thioredoxin/glutathione peroxidase BtuE, reduces lipid peroxides [Defense mechanisms, Lipid transport and metabolism]; COG0386" /db_xref="CDD:440155" CDS 1..162 /gene="GPX2" /locus_tag="YBR244W" /gene_synonym="AMI1" /coded_by="NM_001178592.3:1..489" /experiment="EXISTENCE:direct assay:GO:0004602 glutathione peroxidase activity [PMID:11875065|PMID:11445588]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21763276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity [PMID:11445588]" /experiment="EXISTENCE:mutant phenotype:GO:0004602 glutathione peroxidase activity [PMID:10480913]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11445588]" /experiment="EXISTENCE:mutant phenotype:GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity [PMID:11445588]" /note="Phospholipid hydroperoxide glutathione peroxidase; late-acting antioxidant system that decreases mitochondrial ROS production and preserves electron transport chain (ETC) function; protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; induced by glucose starvation; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852546" /db_xref="SGD:S000000448" ORIGIN 1 mttsfydlec kdkkgesfkf dqlkgkvvli vnvaskcgft pqykeleely kkyqdkgfvi 61 lgfpcnqfgk qepgsdeqit efcqlnygvt fpimkkidvn gsnadsvyny lksqkagllg 121 fkgikwnfek flvdsngkvv qrfssltkps sldqeiqsll sk // LOCUS NP_009804 1129 aa linear PLN 30-JUN-2025 DEFINITION chromatin-remodeling ATPase ISW1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009804 VERSION NP_009804.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178593.1 REFERENCE 1 (residues 1 to 1129) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1129) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1129) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1129) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07361. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1129 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1129 /product="chromatin-remodeling ATPase ISW1" /calculated_mol_wt="130971" Region 108..1057 /region_name="PLN03142" /note="Probable chromatin-remodeling complex ATPase chain; Provisional" /db_xref="CDD:215601" CDS 1..1129 /gene="ISW1" /locus_tag="YBR245C" /gene_synonym="SGN2" /coded_by="NM_001178593.1:1..3390" /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:17259992]" /experiment="EXISTENCE:direct assay:GO:0000976 transcription cis-regulatory region binding [PMID:23468649]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0003730 mRNA 3'-UTR binding [PMID:36284099]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:36284099|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006354 DNA-templated transcription elongation [PMID:15949446]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0030874 nucleolar chromatin [PMID:17259992]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0036436 Isw1a complex [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0036437 Isw1b complex [PMID:12482963]" /experiment="EXISTENCE:genetic interaction:GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter [PMID:19948887]" /experiment="EXISTENCE:genetic interaction:GO:0006363 termination of RNA polymerase I transcription [PMID:17259992]" /experiment="EXISTENCE:genetic interaction:GO:0006369 termination of RNA polymerase II transcription [PMID:12504018]" /experiment="EXISTENCE:genetic interaction:GO:0140750 nucleosome array spacer activity [PMID:26861626|PMID:21940898]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:11238381]" /experiment="EXISTENCE:mutant phenotype:GO:0006354 DNA-templated transcription elongation [PMID:15949446]" /experiment="EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:27185881]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16468993]" /experiment="EXISTENCE:mutant phenotype:GO:0046832 negative regulation of RNA export from nucleus [PMID:36284099]" /experiment="EXISTENCE:mutant phenotype:GO:0140750 nucleosome array spacer activity [PMID:26861626]" /experiment="EXISTENCE:mutant phenotype:GO:1902275 regulation of chromatin organization [PMID:22922743]" /experiment="EXISTENCE:mutant phenotype:GO:1903895 negative regulation of IRE1-mediated unfolded protein response [PMID:36284099]" /note="ATPase subunit of imitation-switch (ISWI) class chromatin remodelers; with Ioc3p forms Isw1a complex involved in repression of transcription initiation; with Ioc2p and Ioc4p forms Isw1b complex involved in regulation of transcription elongation; Isw1b recruited to ORFs by H3K36 methylation and acts with Chd1p to prevent trans-histone exchange over coding regions; binds to 3'UTR of HAC1 mRNA and limits its nuclear export attenuating the UPR" /db_xref="GeneID:852547" /db_xref="SGD:S000000449" ORIGIN 1 maymlaianf hffkfytrmr kkhennscne kdkdenlfki ilaiflqekk kydcissgsi 61 mtaseeylen lkpfqvglpp hdpesnkkry llkdangkkf dlegttkrfe hllslsglfk 121 hfieskaakd pkfrqvldvl eenkangkgk gkhqdvrrrk teheedaell keedsdddes 181 iefqfrespa yvngqlrpyq iqgvnwlvsl hknkiagila demglgktlq tisflgylry 241 iekipgpflv iapkstlnnw lreinrwtpd vnafilqgdk eeraeliqkk llgcdfdvvi 301 asyeiiirek splkkinwey iiideahrik neesmlsqvl reftsrnrll itgtplqnnl 361 helwallnfl lpdifsdaqd fddwfssest eedqdkivkq lhtvlqpfll rriksdvets 421 llpkkelnly vgmssmqkkw ykkilekdld avngsngske sktrllnimm qlrkccnhpy 481 lfdgaepgpp yttdehlvyn aaklqvldkl lkklkeegsr vlifsqmsrl ldiledycyf 541 rnyeycridg stahedriqa iddynapdsk kfvfllttra gglginltsa dvvvlydsdw 601 npqadlqamd rahrigqkkq vkvfrlvtdn sveekilera tqklrldqlv iqqnrtslkk 661 kenkadskda llsmiqhgaa dvfksgtstg sagtpepgsg ekgddidlde lllksenktk 721 slnakyetlg lddlqkfnqd sayewngqdf kkkiqrdiis plllnptkre rkenysidny 781 ykdvlntgrs stpshprmpk phvfhshqlq ppqlkvlyek ermwtakktg yvptmddvka 841 aygdisdeee kkqklellkl svnnsqplte eeekmkadwe segftnwnkl efrkfitvsg 901 kygrnsiqai arelapgktl eevrayakaf wsnieriedy ekylkiiene eekikrvkmq 961 qealrrklse yknpffdlkl khppssnnkr tyseeedrfi llmlfkygld rddvyelvrd 1021 eirdcplfel dfyfrsrtpv elarrgntll qclekefnag ivlddatkdr mkkedengkr 1081 ireefadqta nekenvdgve skkakiedts nvgteqlvae kipenetth // LOCUS NP_009805 387 aa linear PLN 30-JUN-2025 DEFINITION diphthamide synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009805 VERSION NP_009805.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178594.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 387) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07362. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..387 /product="diphthamide synthase" /EC_number="3.1.1.97" /calculated_mol_wt="43177" Region 65..>130 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 68..117 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 122..194 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 201..239 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 246..298 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 305..355 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 362..385 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..387 /gene="RRT2" /locus_tag="YBR246W" /gene_synonym="DPH7; ERE1" /coded_by="NM_001178594.1:1..1164" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21880895]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:21880895]" /experiment="EXISTENCE:direct assay:GO:0061685 diphthine methylesterase activity [PMID:24739148]" /experiment="EXISTENCE:mutant phenotype:GO:0017183 protein histidyl modification to diphthamide [PMID:22188241]" /experiment="EXISTENCE:mutant phenotype:GO:0032456 endocytic recycling [PMID:21880895]" /experiment="EXISTENCE:mutant phenotype:GO:0061685 diphthine methylesterase activity [PMID:24739148]" /note="Methylesterase performing penultimate step of diphthamide biosynthesis; hydrolyzes methylated diphthine to produce diphthine and allows Dph6-catalyzed amidation reaction to occur; deletion leads to resistance to sordarin and accumulation of methylatediphthine; WD40 domain-containing protein; involved in endosomal recycling; forms complex with Rtt10p that functions in retromer-mediated pathway for recycling internalized cell-surface proteins" /db_xref="GeneID:852548" /db_xref="SGD:S000000450" ORIGIN 1 mdsiqesdvl navktklppc clrifrnkii lvgtydldks tgyrsgsldv ftmdlkllcs 61 nntygaildl klspfddtli ctahstgnim lwrirctdkd dfqsneldih aianlqlfek 121 dvliaschfs pldckkllvt ntageaatid irtlsvqfta saiaqayskl dkidyevqga 181 tekvihvesg qflkphelec wtaefgslqp fqdvvftggd dsrimahdlr skefiwsnnr 241 ihdagvvsik csqpnfrnnk ptsiitgsyd dnirsldlrm mgesifpgan vptvnklacd 301 lgggvwrfve spidqeqshh ngsdrllvcc myngakvvtm ndnsdeyfqi qhylkkghds 361 mcyggdwsns liatcsfydn slqtwiv // LOCUS NP_009806 483 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-binding rRNA-processing protein ENP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009806 VERSION NP_009806.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178595.3 REFERENCE 1 (residues 1 to 483) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 483) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 483) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 483) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07363. On Jul 30, 2012 this sequence version replaced NP_009806.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..483 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..483 /product="snoRNA-binding rRNA-processing protein ENP1" /calculated_mol_wt="55006" Region 156..470 /region_name="Bystin" /note="pfam05291" /db_xref="CDD:461612" CDS 1..483 /gene="ENP1" /locus_tag="YBR247C" /gene_synonym="MEG1" /coded_by="NM_001178595.3:1..1452" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9034325]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:12527778]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:16738661]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12527778]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:27385342]" /experiment="EXISTENCE:physical interaction:GO:0006364 rRNA processing [PMID:12527778]" /note="Protein associated with U3 and U14 snoRNAs; required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus; human BYSL functionally complements the heat sensitivity of an enp1 ts mutant" /db_xref="GeneID:852549" /db_xref="SGD:S000000451" ORIGIN 1 marasstkar kqrhdpllkd ldaaqgtlkk inkkklaqnd aanhdaanee dgyidskasr 61 kilqlakeqq deiegeelae sernkqfear fttmsydded edededeeaf gedisdfepe 121 gdykeeeeiv eideedaamf eqyfkksddf nslsgsynla dkimasirek esqvedmqdd 181 eplaneqnts rgnissglks gegvalpekv ikayttvgsi lktwthgklp klfkvipslr 241 nwqdviyvtn peewsphvvy eatklfvsnl takesqkfin lillerfrdn ietsedhsln 301 yhiyravkks lykpsaffkg flfplvetgc nvreatiags vlakvsvpal hssaalsyll 361 rlpfsppttv fikilldkky alpyqtvddc vyyfmrfril ddgsngedat rvlpviwhka 421 fltfaqrykn ditqdqrdfl letvrqrghk digpeirrel lagasrefvd pqeanddlmi 481 dvn // LOCUS NP_009807 552 aa linear PLN 30-JUN-2025 DEFINITION imidazoleglycerol-phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009807 VERSION NP_009807.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178596.3 REFERENCE 1 (residues 1 to 552) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 552) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 552) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 552) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07364. On Jul 30, 2012 this sequence version replaced NP_009807.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..552 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..552 /product="imidazoleglycerol-phosphate synthase" /EC_number="3.5.1.2" /EC_number="4.3.2.10" /calculated_mol_wt="60937" Region 2..549 /region_name="PLN02617" /note="imidazole glycerol phosphate synthase hisHF" /db_xref="CDD:178226" CDS 1..552 /gene="HIS7" /locus_tag="YBR248C" /coded_by="NM_001178596.3:1..1659" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:14190241]" /experiment="EXISTENCE:direct assay:GO:0000107 imidazoleglycerol-phosphate synthase activity [PMID:10733892]" /experiment="EXISTENCE:direct assay:GO:0004359 glutaminase activity [PMID:10733892]" /experiment="EXISTENCE:mutant phenotype:GO:0000105 L-histidine biosynthetic process [PMID:14190241]" /note="Imidazole glycerol phosphate synthase; glutamine amidotransferase:cyclase that catalyzes the fifth step of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor" /db_xref="GeneID:852550" /db_xref="SGD:S000000452" ORIGIN 1 mpvvhvidve sgnlqsltna iehlgyevql vkspkdfnis gtsrlilpgv gnyghfvdnl 61 fnrgfekpir eyiesgkpim gicvglqalf agsvespkst glnyidfkls rfddsekpvp 121 eigwnscips enlffgldpy kryyfvhsfa ailnsekkkn lendgwkiak akygseefia 181 avnknnifat qfhpeksgka glnvienflk qqsppipnys aeekellmnd ysnygltrri 241 iacldvrtnd qgdlvvtkgd qydvreksdg kgvrnlgkpv qlaqkyyqqg adevtflnit 301 sfrdcplkdt pmlevlkqaa ktvfvpltvg ggikdivdvd gtkipaleva slyfrsgadk 361 vsigtdavya aekyyelgnr gdgtspieti skaygaqavv isvdpkrvyv nsqadtknkv 421 feteypgpng ekycwyqcti kggresrdlg vweltracea lgageillnc idkdgsnsgy 481 dleliehvkd avkipviass gagvpehfee aflktradac lgagmfhrge ftvndvkeyl 541 lehglkvrmd ee // LOCUS NP_009808 370 aa linear PLN 30-JUN-2025 DEFINITION 3-deoxy-7-phosphoheptulonate synthase ARO4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009808 VERSION NP_009808.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178597.1 REFERENCE 1 (residues 1 to 370) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 370) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 370) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 370) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07365. Method: conceptual translation. FEATURES Location/Qualifiers source 1..370 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..370 /product="3-deoxy-7-phosphoheptulonate synthase ARO4" /EC_number="2.5.1.54" /calculated_mol_wt="39618" Region 21..365 /region_name="aroFGH" /note="phospho-2-dehydro-3-deoxyheptonate aldolase; TIGR00034" /db_xref="CDD:129145" CDS 1..370 /gene="ARO4" /locus_tag="YBR249C" /coded_by="NM_001178597.1:1..1113" /experiment="EXISTENCE:direct assay:GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity [PMID:2880280]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /note="3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:852551" /db_xref="SGD:S000000453" ORIGIN 1 msespmfaan gmpkvnqgae edvrilgydp laspallqvq ipatptslet akrgrreaid 61 iitgkddrvl vivgpcsihd leaaqeyalr lkklsdelkg dlsiimrayl ekprttvgwk 121 glindpdvnn tfninkglqs arqlfvnltn iglpigseml dtispqylad lvsfgaigar 181 ttesqlhrel asglsfpvgf kngtdgtlnv avdacqaaah shhfmgvtkh gvaaitttkg 241 nehcfvilrg gkkgtnydak svaeakaqlp agsnglmidy shgnsnkdfr nqpkvndvvc 301 eqiangenai tgvmiesnin egnqgipaeg kaglkygvsi tdacigwett edvlrklaaa 361 vrqrrevnkk // LOCUS NP_009809 523 aa linear PLN 30-JUN-2025 DEFINITION Spo23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009809 VERSION NP_009809.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178598.1 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 523) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07366. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..523 /product="Spo23p" /calculated_mol_wt="59788" CDS 1..523 /gene="SPO23" /locus_tag="YBR250W" /coded_by="NM_001178598.1:1..1572" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:17179081]" /experiment="EXISTENCE:physical interaction:GO:0051321 meiotic cell cycle [PMID:17179081]" /note="hypothetical protein; associates with meiosis-specific protein Spo1p" /db_xref="GeneID:852552" /db_xref="SGD:S000000454" ORIGIN 1 mlfssssssl nsevsqvfse nissrsttlt esstqseirq hfgnedfsge lpkkliqlkk 61 lknggttikk akedleycyd slrlyenpyv tssvdkkcgy sielyldnky ktlmfsdlql 121 nadyplyyds sldnistnve reratplqik gkirinidre dqallitshs islkcftkey 181 acfvnsetsk nsysdkiike lnhteffess typkqqlrvi hhslndkkil ltkgtydypf 241 tftlqantfp asfssffgkt hfriesltti mripskpknl lkflknesft dkiilteeik 301 vkrvlpstsm lkfetfqlrs yntaseivvs vignskliei gmpfqmilsi tktdssielq 361 easlavaqrm aipsidlktk kilrepyikk seyllrtves qsfdsdktif gfcfddvvip 421 tyadglpswf ktfycepssf ypnhaalkvt hlllfritys rnelveglem kknyritvnf 481 pilvgdsdis tssllpkyek fenisdlqde pplysmvage nsl // LOCUS NP_009810 307 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS5m MRPS5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009810 VERSION NP_009810.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178599.3 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 307) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07367. On Jul 30, 2012 this sequence version replaced NP_009810.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..307 /product="mitochondrial 37S ribosomal protein uS5m MRPS5" /calculated_mol_wt="34752" Region 152..302 /region_name="rpsE" /note="30S ribosomal protein S5; Validated; PRK00550" /db_xref="CDD:234790" CDS 1..307 /gene="MRPS5" /locus_tag="YBR251W" /gene_synonym="uS5m" /coded_by="NM_001178599.3:1..924" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:852553" /db_xref="SGD:S000000455" ORIGIN 1 mfkrqlstsv rylqhydesl lsryypesll ksiklaqqti pedtkfrvsr nvefappyld 61 dftkihpfwd ykpgmphlha qeennnfsif rwdqvqqplp gegnilppgv slpndggrks 121 ksadvaaglh kqtgvdpdyi trkltmkplv mkrvsnqtgk gkiasfyalv vvgdkngmvg 181 lgegksreem skaifkahwd avrnlkeipr yenrtiygdi dfryhgvklh lrsakpgfgl 241 rvnhvifeic ecagikdlsg kvyksrndmn iakgtieaft kaqktldeva lgrgkklvdv 301 rkvyyss // LOCUS NP_009811 147 aa linear PLN 30-JUN-2025 DEFINITION bifunctional dITP/dUTP diphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009811 VERSION NP_009811.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178600.3 REFERENCE 1 (residues 1 to 147) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 147) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 147) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 147) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07368. On Jul 30, 2012 this sequence version replaced NP_009811.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..147 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..147 /product="bifunctional dITP/dUTP diphosphatase" /EC_number="3.6.1.23" /calculated_mol_wt="15176" Region 9..146 /region_name="dut" /note="deoxyuridine 5'-triphosphate nucleotidohydrolase (dut); TIGR00576" /db_xref="CDD:273149" Site order(29..30,40,45..46,48,64,66..71,77..79,83,86,93,95,97, 99,103..107,110,114) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:143638" Site order(68..70,83..85,88,92..93) /site_type="active" /db_xref="CDD:143638" CDS 1..147 /gene="DUT1" /locus_tag="YBR252W" /coded_by="NM_001178600.3:1..444" /experiment="EXISTENCE:direct assay:GO:0004170 dUTP diphosphatase activity [PMID:21548881]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0035863 dITP catabolic process [PMID:21548881]" /experiment="EXISTENCE:direct assay:GO:0035870 dITP diphosphatase activity [PMID:21548881]" /experiment="EXISTENCE:direct assay:GO:0046081 dUTP catabolic process [PMID:21548881]" /experiment="EXISTENCE:mutant phenotype:GO:0004170 dUTP diphosphatase activity [PMID:8223452|PMID:21548881]" /experiment="EXISTENCE:mutant phenotype:GO:0009213 pyrimidine deoxyribonucleoside triphosphate catabolic process [PMID:8223452]" /experiment="EXISTENCE:mutant phenotype:GO:0046081 dUTP catabolic process [PMID:21548881]" /note="Deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activity on deoxyinosine triphosphate; human homolog DUT allows growth of yeast haploid dut1 null mutant after sporulation of heterozygous diploid" /db_xref="GeneID:852554" /db_xref="SGD:S000000456" ORIGIN 1 mtatsdkvlk iqlrsasatv ptkgsataag ydiyasqdit ipamgqgmvs tdisftvpvg 61 tygriaprsg lavkngiqtg agvvdrdytg evkvvlfnhs qrdfaikkgd rvaqlileki 121 vddaqivvvd sleesargag gfgstgn // LOCUS NP_009812 121 aa linear PLN 30-JUN-2025 DEFINITION Srb6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009812 VERSION NP_009812.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178601.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 121) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07369. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..121 /product="Srb6p" /calculated_mol_wt="13732" Region 8..113 /region_name="Med22" /note="Surfeit locus protein 5 subunit 22 of Mediator complex; pfam06179" /db_xref="CDD:461845" CDS 1..121 /gene="SRB6" /locus_tag="YBR253W" /gene_synonym="MED22" /coded_by="NM_001178601.1:1..366" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8187178]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" /db_xref="GeneID:852555" /db_xref="SGD:S000000457" ORIGIN 1 msnqalyekl eqtrtilsvk laelinmtti adrndddegs faqenselav attsvmmvnn 61 qtmqliknvq dlliltrsik ekwllnqipv tehskvtrfd ekqieelldn cietfvaekt 121 t // LOCUS NP_009813 175 aa linear PLN 30-JUN-2025 DEFINITION TRAPP subunit TRS20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009813 VERSION NP_009813.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178602.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 175) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07370. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..175 /product="TRAPP subunit TRS20" /calculated_mol_wt="19569" Region 1..173 /region_name="TRS20" /note="Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion]; COG5603" /db_xref="CDD:227890" CDS 1..175 /gene="TRS20" /locus_tag="YBR254C" /coded_by="NM_001178602.1:1..528" /experiment="EXISTENCE:direct assay:GO:1990070 TRAPPI protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990072 TRAPPIII protein complex [PMID:20375281]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9564032]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11239471]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:23465091]" /note="Core component of transport protein particle (TRAPP) complexes I-III; TRAPPs are multimeric guanine nucleotide-exchange factors for GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); mutation leads to defects in endocytic recycling, block in sporulation/meiosis; mutations in human homolog TRAPPC2 cause spondyloepiphyseal dysplasia tarda, TRAPPC2 can complement yeast null mutant" /db_xref="GeneID:852556" /db_xref="SGD:S000000458" ORIGIN 1 mpqyfaiigk kdnpvyeief tnaenpqgfp qdlkelnpfi lhasldived lqwqinptsq 61 lngnggngsn ggggflrsra vnntdncylg kvdhfyglai tayisysgmk fvmihgnsan 121 ssvviddnnm rsfyqevhel yvktlmnpfy kitdpirspa fdsrvrtlar khlsk // LOCUS NP_009814 694 aa linear PLN 30-JUN-2025 DEFINITION Mtc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009814 VERSION NP_009814.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178603.3 REFERENCE 1 (residues 1 to 694) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 694) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 694) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 694) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07371. On Jul 30, 2012 this sequence version replaced NP_009814.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..694 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..694 /product="Mtc4p" /calculated_mol_wt="78897" CDS 1..694 /gene="MTC4" /locus_tag="YBR255W" /coded_by="NM_001178603.3:1..2085" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27663510]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:27663510]" /note="hypothetical protein; required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1" /db_xref="GeneID:852557" /db_xref="SGD:S000000459" ORIGIN 1 mthtnehdhk aeqqqngrgd tttetvnpqk mklvtkllid nkfglmddln fsipltasse 61 gvpisaktse lgteylknqq ensvspilpi srstrikadr vriyldyyyn ilercisids 121 sqnhhegveg vynplqvirn rklkkkhhel ptrefyttkh piiaikqfsk kpnkkmpwfv 181 dinekymdlt wrtshweelv dpqgklwfqs yspsnessgs sssrrhhghh ihprrhlqhh 241 srvrtansvh sntqsltpkr vmtneednnn hnnnnmitki attpeaqisr nkksdlnlsh 301 ihlevpitnt vtntssdqgs liieakgssy ggdrrgssnt sgsggkrnsk hyrsksagpp 361 eneksrmngl ekiisktskg wsrspkkntp glekqvllnp tisnggtsrr ssnngesist 421 nsskssmgit fgntetyktp vdngkdaiir qsllsevpvh tlrgktsnrs lraegeqale 481 sdkelpngag siyegaprek ttsqgsepvg lvsdslqvde qlqrywhdtr yimstvammq 541 hrrethdivk rreiarrnei eitqdadtni rktadaltqy dnelnkvlkl gndwtsklln 601 dysirvetli sssdrilsdi nttltlklkm fqenteryvt vkvmraqkmt ktiyrllefg 661 ivlvlwtiwf lfsvlrsirf tiflvlkiik allw // LOCUS NP_116328 120 aa linear PLN 30-JUN-2025 DEFINITION Rcf3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116328 VERSION NP_116328.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184510.3 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 120) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07372. On Jul 30, 2012 this sequence version replaced NP_116328.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..120 /product="Rcf3p" /calculated_mol_wt="13610" CDS 1..120 /gene="RCF3" /locus_tag="YBR255C-A" /coded_by="NM_001184510.3:1..363" /note="Mitochondrial inner membrane protein; associates with respiratory chain supercomplexes III (ubiquinol-cytochrome c reductase) and IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species" /db_xref="GeneID:852558" /db_xref="SGD:S000007649" ORIGIN 1 mggnvlpihy dpktvkqltk eitvasciga aqgalfsias alllrrfssv yrnvrtqvrv 61 fyhcswismg avfradkqll kfqtnyyree qkrrekimde aaerglfled eslnssrstt // LOCUS NP_009815 238 aa linear PLN 30-JUN-2025 DEFINITION riboflavin synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009815 VERSION NP_009815.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178604.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 238) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07373. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..238 /product="riboflavin synthase" /EC_number="2.5.1.9" /calculated_mol_wt="26065" Region 1..210 /region_name="ribE" /note="riboflavin synthase, alpha subunit; TIGR00187" /db_xref="CDD:272950" CDS 1..238 /gene="RIB5" /locus_tag="YBR256C" /coded_by="NM_001178604.1:1..717" /experiment="EXISTENCE:direct assay:GO:0004746 riboflavin synthase activity [PMID:7814407]" /experiment="EXISTENCE:mutant phenotype:GO:0009231 riboflavin biosynthetic process [PMID:7814407]" /note="Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway" /db_xref="GeneID:852559" /db_xref="SGD:S000000460" ORIGIN 1 mftgivecmg tvlennpydd sesggqgvsi tignagsilt dchvgdsiav ngvcltvtef 61 nndsfkvgis petikrsnva swiqgtqvnl eravsqdvrf gghyvqghvd tvanivsrrp 121 egnsiifgfq lrdqeyfkyi vekgficidg tsltiikvdp lsqggafyis mikhtqdnvi 181 mplkkigdev nievdltgki iekqilltle nqiskkdstl ntmisniiee kvrnylnk // LOCUS NP_009816 279 aa linear PLN 30-JUN-2025 DEFINITION RNase P/RNase MRP complex subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_009816 VERSION NP_009816.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178605.1 REFERENCE 1 (residues 1 to 279) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 279) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 279) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 279) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07374. Method: conceptual translation. FEATURES Location/Qualifiers source 1..279 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..279 /product="RNase P/RNase MRP complex subunit" /calculated_mol_wt="32750" Region 172..263 /region_name="RNase_P-MRP_p29" /note="Ribonuclease P/MRP, subunit p29; pfam01868" /db_xref="CDD:460367" CDS 1..279 /gene="POP4" /locus_tag="YBR257W" /coded_by="NM_001178605.1:1..840" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9085845|PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:23700311]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0030677 ribonuclease P complex [PMID:9085845]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:17881380]" /experiment="EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:9085845]" /experiment="EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9085845]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9085845]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9085845]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]" /note="Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P" /db_xref="GeneID:852560" /db_xref="SGD:S000000461" ORIGIN 1 mdrtqtfikd clftkcledp ekpfnenrfq dtllllptdg gltsrlqrqq rksklnldnl 61 qkvsqlesad kqlekrdyqr inknskialr eyinnckknt kkclklayen kitdkedllh 121 yieekhptiy eslpqyvdfv pmykelwiny ikellnitkn lktfngslal lklsmadyng 181 allrvtkskn ktliglqgiv iwdsqkffim ivkgniidei kcipkkgtvf qfeipisddd 241 dsalrysilg drfkyrsvdr agrkfksrrc ddmlyyiqn // LOCUS NP_009817 142 aa linear PLN 30-JUN-2025 DEFINITION Shg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009817 VERSION NP_009817.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178606.3 REFERENCE 1 (residues 1 to 142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 142) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07375. On Jul 30, 2012 this sequence version replaced NP_009817.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..142 /product="Shg1p" /calculated_mol_wt="16298" Region 11..126 /region_name="COMPASS-Shg1" /note="COMPASS (Complex proteins associated with Set1p) component shg1; pfam05205" /db_xref="CDD:461586" CDS 1..142 /gene="SHG1" /locus_tag="YBR258C" /gene_synonym="CPS15" /coded_by="NM_001178606.3:1..429" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:11742990|PMID:11805083]" /experiment="EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11742990|PMID:11805083]" /experiment="EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11805083|PMID:11742990]" /note="Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres" /db_xref="GeneID:852561" /db_xref="SGD:S000000462" ORIGIN 1 maynqedskr lsdkykkegh fdklkreils npwnnteens esfeqalrkr vastvkemvn 61 edeelifknr gltsaliesq lvkdnylklg skmegdngdg ekkfdldvyv rsklqdpkll 121 emikgqlqet lnsyeeeang st // LOCUS NP_009818 688 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR259W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009818 VERSION NP_009818.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178607.3 REFERENCE 1 (residues 1 to 688) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 688) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 688) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 688) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07376. On Jul 30, 2012 this sequence version replaced NP_009818.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..688 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..688 /product="uncharacterized protein" /calculated_mol_wt="80296" CDS 1..688 /locus_tag="YBR259W" /coded_by="NM_001178607.3:1..2067" /note="hypothetical protein; YBR259W is not an essential gene; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:852562" /db_xref="SGD:S000000463" ORIGIN 1 msideavary rdvignlatg nlrriviqse klaqiiassk gtvrfhhktr sgktviykci 61 kkallssvas lssefssetd vqqflhlnyi yqshfqalsg qinkycgmkk yyelkfaaid 121 yletevqttg ltlsrfwvas ldefikkerw pdngsnfqif yklmaeyssw kwdsddkrql 181 qfmyefrmkl keclvkfyen fdlqkssdpl keliipweki vyvancidaf tgeqvridga 241 eliwtsknlv fssissavlr lndlqnmfsa frpygeealv qdfahirslk wdsndkvesl 301 iralifndmf pyfnkeqvdt kadgifflrl lrknfkehin dvkdfhiqvi kylnsqfknn 361 ystlmtsskt qdrrkshnmp ssilddgnki gmhvspidey shfidndepl wrdkvypkiy 421 tneqtptpda saifdshkiy aiisllryyl pekrkffriy ylpsifkril yygakfaqly 481 fmegclerlv ieslqileps lvhainnlik ssieslknvt vtsddktssg viilsykefk 541 slsevnkdfn epfwpnqsia nswpdfankq lkrgqilqda fafhlfeiel piiidttrnt 601 hlklvsnmct tsilylynev dslsltsiqe klavlptskr neillynlnr ltklkllllk 661 enekgqkfya fnfkykrdgq ktslirli // LOCUS NP_009819 666 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein RGD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009819 VERSION NP_009819.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178608.1 REFERENCE 1 (residues 1 to 666) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 666) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 666) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 666) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07377. Method: conceptual translation. FEATURES Location/Qualifiers source 1..666 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..666 /product="GTPase-activating protein RGD1" /calculated_mol_wt="74488" Region 39..268 /region_name="F-BAR_Rgd1" /note="The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Saccharomyces cerevisiae Rho GTPase activating protein Rgd1 and similar proteins; cd07652" /db_xref="CDD:153336" Site order(44,47,54,57..58,61,64..65,68..69,72,76,79,83,108,111, 194,198,223,228,231,234..235,238,242,245,249,253,256..257, 260) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153336" Region 470..663 /region_name="RhoGAP_fRGD1" /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as...; cd04398" /db_xref="CDD:239863" Site order(508,552,556,625,628..629,649) /site_type="other" /note="putative GTPase interaction site [polypeptide binding]" /db_xref="CDD:239863" Site 508 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:239863" CDS 1..666 /gene="RGD1" /locus_tag="YBR260C" /coded_by="NM_001178608.1:1..2001" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:10526184]" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:25620000|PMID:21215255]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:10931290]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:18845541]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10931290]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:18845541]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:18845541]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:18845541]" /experiment="EXISTENCE:genetic interaction:GO:0005096 GTPase activator activity [PMID:10526184]" /experiment="EXISTENCE:genetic interaction:GO:0006970 response to osmotic stress [PMID:10590461]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:40365021]" /experiment="EXISTENCE:mutant phenotype:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:18845541]" /experiment="EXISTENCE:mutant phenotype:GO:0010447 response to acidic pH [PMID:16087742]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:40365021]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:33508381]" /experiment="EXISTENCE:mutant phenotype:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:18845541]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:33508381]" /experiment="EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:18845541]" /experiment="EXISTENCE:mutant phenotype:GO:0070528 protein kinase C signaling [PMID:33508381]" /experiment="EXISTENCE:mutant phenotype:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:18845541]" /note="GTPase-activating protein (RhoGAP) for Rho3p and Rho4p; involved in repolarization of actin cytoskeleton during adaptation to heat shock stress; phosphorylated by Pkc1p; regulator of bulk autophagy" /db_xref="GeneID:852563" /db_xref="SGD:S000000464" ORIGIN 1 meetakkpas atvsaksshd ggtddlahlf stpeikkvln sdvainalls rlkqslltce 61 efmkfirkky afeeehvqel skqykhffni qgstnsslkk mihevlgfdg kmaqvkqsyi 121 talqkmysei ssllltmtkl rksvkenskr lekdvsdaih saekaqsryn slcqdwdklr 181 mtdptktklt lrgskttkeq eeellrkidn adleykqkvd hsnslrntfi tkerprivqe 241 lkdlileidt amtiqlqkyt iwtenlvlnt gvtispldst ksmksfagsv snerdlysfl 301 nkynqtgkhs llinknlipv sykkhpsmnh gqknksppkf avdpsrnsip krmisthnes 361 pflssssnta avpnanlnsa tpslntnkql pptmassiss tsnaagamsp sssivtsdtt 421 ssitktldpg nnspqipeel insldsdrpi shiqtnnnmp pgvqknfktf gvpleslief 481 eqdmvpaivr qciyvidkfg ldqegiyrks anvldvsklk eeidkdpani smilpskphs 541 dsdiylvgsl lktffaslpd svlpkalsse ikvclqiedp ttrknfmhgl iynlpdaqyw 601 tlralvfhlk rvlaheaqnr mnlralciiw gptiapanpd dandvnfqim amevllevsd 661 qafepe // LOCUS NP_009820 232 aa linear PLN 30-JUN-2025 DEFINITION N-terminal protein methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009820 VERSION NP_009820.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178609.1 REFERENCE 1 (residues 1 to 232) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 232) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 232) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 232) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07378. Method: conceptual translation. FEATURES Location/Qualifiers source 1..232 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..232 /product="N-terminal protein methyltransferase" /EC_number="2.1.1.244" /calculated_mol_wt="25937" Region 6..228 /region_name="Methyltransf_PK" /note="AdoMet dependent proline di-methyltransferase; pfam05891" /db_xref="CDD:461771" CDS 1..232 /gene="TAE1" /locus_tag="YBR261C" /gene_synonym="NTM1" /coded_by="NM_001178609.1:1..699" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:20481588]" /experiment="EXISTENCE:direct assay:GO:0018016 N-terminal peptidyl-proline dimethylation [PMID:20481588]" /experiment="EXISTENCE:direct assay:GO:0071885 N-terminal protein N-methyltransferase activity [PMID:20481588]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:19055778]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:19055778]" /experiment="EXISTENCE:mutant phenotype:GO:0018016 N-terminal peptidyl-proline dimethylation [PMID:20481588]" /experiment="EXISTENCE:mutant phenotype:GO:0071885 N-terminal protein N-methyltransferase activity [PMID:20481588]" /note="AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm" /db_xref="GeneID:852564" /db_xref="SGD:S000000465" ORIGIN 1 mdvpadshik yedaidywtd vdatvdgvlg gygegtvvpt mdvlgsnnfl rklksrmlpq 61 ennvkyavdi gagigrvskt mlhkhaakid lvepvkpfie qmhvelaelk dkgqigqiye 121 vgmqdwtpda gkywliwcqw cvghlpdael vaflkrcivg lqpngtivvk enntptdtdd 181 fdetdssvtr sdakfrqife eaglkliase rqrglprely pvrmyalkpm pn // LOCUS NP_009821 106 aa linear PLN 30-JUN-2025 DEFINITION Mic12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009821 VERSION NP_009821.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178610.3 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 106) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07379. On Jul 30, 2012 this sequence version replaced NP_009821.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..106 /product="Mic12p" /calculated_mol_wt="12257" Region <79..102 /region_name="AIM5" /note="Altered inheritance of mitochondria 5; pfam17050" /db_xref="CDD:435711" CDS 1..106 /gene="MIC12" /locus_tag="YBR262C" /gene_synonym="AIM5; FMP51; MCS12" /coded_by="NM_001178610.3:1..321" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0044284 mitochondrial crista junction [PMID:22009199]" /experiment="EXISTENCE:direct assay:GO:0061617 MICOS complex [PMID:21987634|PMID:22009199|PMID:21944719]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:22009199|PMID:21944719|PMID:21987634]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:26968360]" /note="Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic27p whose assembly and stability requires cardiolipin" /db_xref="GeneID:852566" /db_xref="SGD:S000000466" ORIGIN 1 msklgplars vkwtlsvgvi gsvfylyrys nngyfydhda twlkqdhqvq dlvdrkevvp 61 getrnrklvv tddgtawsrt mgesikdiwn eqirnsvdwi yswgkn // LOCUS NP_009822 490 aa linear PLN 30-JUN-2025 DEFINITION glycine hydroxymethyltransferase SHM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009822 VERSION NP_009822.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178611.3 REFERENCE 1 (residues 1 to 490) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 490) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 490) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 490) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07380. On Jul 30, 2012 this sequence version replaced NP_009822.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..490 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..490 /product="glycine hydroxymethyltransferase SHM1" /EC_number="2.1.2.1" /calculated_mol_wt="53555" Region 33..432 /region_name="SHMT" /note="Serine hydroxymethyltransferase; pfam00464" /db_xref="CDD:395372" Site order(37,39,46..47,56,61,79,97..98,106,125,132,173..174, 312,330) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:99733" Site order(60,80,90,127..128,155,211,236,239,264..265,271,409) /site_type="other" /note="glycine-pyridoxal phosphate binding site [chemical binding]" /db_xref="CDD:99733" Site order(60,155,265,409) /site_type="active" /db_xref="CDD:99733" Site order(82,89,150,154,156,304,394) /site_type="other" /note="folate binding site [chemical binding]" /db_xref="CDD:99733" CDS 1..490 /gene="SHM1" /locus_tag="YBR263W" /gene_synonym="SHMT1; TMP3" /coded_by="NM_001178611.3:1..1473" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:genetic interaction:GO:0006730 one-carbon metabolic process [PMID:9398220]" /experiment="EXISTENCE:mutant phenotype:GO:0004372 glycine hydroxymethyltransferase activity [PMID:1100397]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:6271|PMID:9398220]" /experiment="EXISTENCE:mutant phenotype:GO:0006730 one-carbon metabolic process [PMID:1100397]" /note="Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine" /db_xref="GeneID:852565" /db_xref="SGD:S000000467" ORIGIN 1 mfprasalak cmatvhrrgl ltsgaqslvs kpvsegdpem fdilqqerhr qkhsitlips 61 enftskavmd llgselqnky segypgeryy ggneiidkse slcqaralel ygldpakwgv 121 nvqplsgapa nlyvysaimn vgerlmgldl pdgghlshgy qlksgtpisf iskyfqsmpy 181 hvdhttglid ydnlqvlaka frpkvivagt saysrlidya rfkeisqgcg aylmsdmahi 241 sglvaanvvp spfehsdivt ttthkslrgp rgamiffrkg iksvtkkgke ipyelekkin 301 fsvfpghqgg phnhtigama valkqamspe fkeyqqkivd nskwfaqelt kmgyklvsgg 361 tdnhlividl sgtqvdgarv etilsalnia ankntipgdk salfpsglri gtpamttrgf 421 greefsqvak yidsavklae nlktlepttk ldarsrlnef kklcnessev aalsgeiskw 481 vgqypvpgdi // LOCUS NP_009823 199 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase YPT10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009823 VERSION NP_009823.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178612.1 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 199) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07381. On Oct 2, 2003 this sequence version replaced NP_009823.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..199 /product="Rab family GTPase YPT10" /calculated_mol_wt="21703" Region 5..158 /region_name="Rab" /note="Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); cd00154" /db_xref="CDD:206640" Site 5..6 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206640" Site 11..18 /site_type="other" /note="G1 box" /db_xref="CDD:206640" Site order(13..19,29,36,68,122..123,125,150..152) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206640" Site 19..29 /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206640" Site order(29,36..42) /site_type="other" /note="Switch I region" /db_xref="CDD:206640" Site 36 /site_type="other" /note="G2 box" /db_xref="CDD:206640" Site order(37,39..41,62,64,71..72,75,79,84) /site_type="active" /note="effector interaction site [active]" /db_xref="CDD:206640" Site order(37..38,40,64..65,72,76..78) /site_type="active" /note="GDI interaction site [active]" /db_xref="CDD:206640" Site 37..41 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206640" Site order(38..45,58,60) /site_type="other" /note="GEF interaction site [polypeptide binding]" /db_xref="CDD:206640" Site 60..64 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206640" Site 65..68 /site_type="other" /note="G3 box" /db_xref="CDD:206640" Site order(68,70..73,75..80) /site_type="other" /note="Switch II region" /db_xref="CDD:206640" Site order(71..73,75..76) /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206640" Site 79..80 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206640" Site 88..93 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206640" Site 115..119 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206640" Site 122..125 /site_type="other" /note="G4 box" /db_xref="CDD:206640" Site 150..152 /site_type="other" /note="G5 box" /db_xref="CDD:206640" CDS 1..199 /gene="YPT10" /locus_tag="YBR264C" /coded_by="NM_001178612.1:1..600" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019001 guanyl nucleotide binding [PMID:10394895]" /experiment="EXISTENCE:mutant phenotype:GO:0007030 Golgi organization [PMID:10394895]" /note="Rab family GTP-binding protein; contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles" /db_xref="GeneID:852567" /db_xref="SGD:S000000468" ORIGIN 1 meatikvvll gdssvgktsi vtrlksgkfl akhaatigaa fitktievps ndsstekrih 61 meiwdtagqe rykslvpmyy rdanialivf elgdvsslqc aktwfqdlqd raqgtqviiv 121 gnkydlvcee hsgevtipae lqglpyvavs aktgynfdtl nkiiislvpe sqfktlsknn 181 eqgnileink kksgsgcic // LOCUS NP_009824 320 aa linear PLN 30-JUN-2025 DEFINITION 3-dehydrosphinganine reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009824 VERSION NP_009824.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178613.2 REFERENCE 1 (residues 1 to 320) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 320) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 320) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 320) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07382. On Apr 26, 2011 this sequence version replaced NP_009824.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..320 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..320 /product="3-dehydrosphinganine reductase" /EC_number="1.1.1.102" /calculated_mol_wt="35842" Region 7..263 /region_name="KDSR-like_SDR_c" /note="3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR; cd08939" /db_xref="CDD:187643" Site order(14,16..19,40..42,88..90,116..118,139,165..167,180, 184,208..211,213..214) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:187643" Site order(93,124..126,128,133,137,145,149,173..176,178, 181..182,185..186,188..190,192..194,196..197,202,241,245, 249,251..252,258..263) /site_type="other" /note="homotetramer interface [polypeptide binding]" /db_xref="CDD:187643" Site order(140,167,180,184) /site_type="active" /db_xref="CDD:187643" Site order(200,202,241,244..245,249,251,258..263) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:187643" CDS 1..320 /gene="TSC10" /locus_tag="YBR265W" /coded_by="NM_001178613.2:1..963" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0006666 3-keto-sphinganine metabolic process [PMID:9804843]" /experiment="EXISTENCE:direct assay:GO:0030148 sphingolipid biosynthetic process [PMID:9804843]" /experiment="EXISTENCE:direct assay:GO:0047560 3-dehydrosphinganine reductase activity [PMID:9804843]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:9804843]" /note="3-ketosphinganine reductase; catalyzes the second step in phytosphingosine synthesis; essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine; localized to lipid droplets; member of short chain dehydrogenase/reductase protein family; mutations in human homolog KDSR cause recessive progressive symmetric erythrokeratoderma" /db_xref="GeneID:852568" /db_xref="SGD:S000000469" ORIGIN 1 mkftledqvv litggsqglg kefakkyyne aentkiiivs rsearlldtc neirieahlr 61 rettdegqvq hklaapldle qrlfyypcdl scyesveclf nalrdldllp tqtlccagga 121 vpklfrglsg helnlgmdin ykttlnvahq ialaeqtkeh hliifssata lypfvgysqy 181 apakaaiksl vailrqeltn friscvypgn fesegftveq ltkpeitkli egpsdaipck 241 qacdiiaksl argdddvftd fvgwmimgmd lgltakksrf vplqwifgvl snilvvpfym 301 vgcswyirkw frendgkkan // LOCUS NP_009825 393 aa linear PLN 30-JUN-2025 DEFINITION Rei1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009825 VERSION NP_009825.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178615.4 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 393) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07383. On Jul 30, 2012 this sequence version replaced NP_009825.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..393 /product="Rei1p" /calculated_mol_wt="45732" Region <9..50 /region_name="PTZ00448" /note="hypothetical protein; Provisional" /db_xref="CDD:185627" Region 9..31 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275371" Region 164..263 /region_name="zf-C2H2_2" /note="C2H2 type zinc-finger (2 copies); pfam12756" /db_xref="CDD:463690" Region 217..239 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275371" CDS 1..393 /gene="REI1" /locus_tag="YBR267W" /coded_by="NM_001178615.4:1..1182" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:15107529]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:16648468]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:genetic interaction:GO:0000278 mitotic cell cycle [PMID:15107529]" /experiment="EXISTENCE:genetic interaction:GO:0007117 budding cell bud growth [PMID:15107529]" /experiment="EXISTENCE:genetic interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:16648468]" /experiment="EXISTENCE:mutant phenotype:GO:0006913 nucleocytoplasmic transport [PMID:16651379]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:16651379|PMID:16648468]" /note="Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network" /db_xref="GeneID:852569" /db_xref="SGD:S000000471" ORIGIN 1 msssgvytcn scvltfdssd eqrahmksdw hrynlkrrva qlppisfetf dskvsaaaas 61 tsksaekekp vtkkelkrre kqallekkkk lleiaranml enmqksqegn tpdlsklslq 121 eneenkekee pkkeepeqlt eeemaervmq eklrnrvdip leqclfcehn khfkdveenl 181 ehmfrthgfy ipeqkylvdk iglvkymsek iglgnicivc nyqgrtltav rqhmlakrhc 241 kipyeseder leisefydft ssyanfnsnt tpdneddwed vgsdeagsdd edlpqeylyn 301 dgielhlptg ikvghrslqr yykqdlkpev iltegqgtlv aaetrsflpa fdkkgvqtqq 361 rvwqterfdk krldkrsakf vnnqphyrdq llq // LOCUS NP_001381962 150 aa linear PLN 30-JUN-2025 DEFINITION Slm6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381962 VERSION NP_001381962.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395042.1 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 150) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54803. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..150 /product="Slm6p" /calculated_mol_wt="15897" CDS 1..150 /gene="SLM6" /locus_tag="YBR266C" /coded_by="NM_001395042.1:1..453" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903]" /note="Protein with potential role in actin cytoskeleton organization; null mutant is slow-growing, sensitive to Congo Red, impaired in endocytosis, has increased lifespan; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase" /db_xref="GeneID:852570" /db_xref="SGD:S000000470" ORIGIN 1 mcsrfsstsl kcllcsqnrh cssgistllr sfscitlsai sssvncsgss flgssfslfs 61 sfsckesllr sgvfpswlfc mfssilalai snsffffssn acfsllfnsf lvtgfsfsad 121 llvlaaaadt lesnvsndig gncatrlfkl // LOCUS NP_009827 105 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL54 MRPL37 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009827 VERSION NP_009827.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178616.3 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 105) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07384. On Jul 30, 2012 this sequence version replaced NP_009827.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..105 /product="mitochondrial 54S ribosomal protein mL54 MRPL37" /calculated_mol_wt="11818" Region 25..103 /region_name="Ribosomal_L37" /note="Mitochondrial ribosomal protein L37; pfam08561" /db_xref="CDD:430074" CDS 1..105 /gene="MRPL37" /locus_tag="YBR268W" /gene_synonym="mL54" /coded_by="NM_001178616.3:1..318" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:2060626]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:852571" /db_xref="SGD:S000000472" ORIGIN 1 mlarslgyrl istsrilynk ptvksvvssc pagtslnlni wksgkdaval edkeypnwlw 61 svldsdhvve haaedpegqa llkrrknirk anrqrikqnn flsql // LOCUS NP_009828 138 aa linear PLN 30-JUN-2025 DEFINITION Sdh8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009828 VERSION NP_009828.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178617.1 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 138) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07385. On Feb 2, 2004 this sequence version replaced NP_009828.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..138 /product="Sdh8p" /calculated_mol_wt="15373" Region <103..138 /region_name="DUF1674" /note="Protein of unknown function (DUF1674); pfam07896" /db_xref="CDD:429724" CDS 1..138 /gene="SDH8" /locus_tag="YBR269C" /gene_synonym="FMP21" /coded_by="NM_001178617.1:1..417" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:24954416]" /experiment="EXISTENCE:mutant phenotype:GO:0034553 mitochondrial respiratory chain complex II assembly [PMID:24954416]" /experiment="EXISTENCE:mutant phenotype:GO:0044183 protein folding chaperone [PMID:24954416]" /note="Protein required for assembly of succinate dehydrogenase; interacts with flavinylated Sdh1p and may function as a chaperone for free Sdh1p, protecting its FAD cofactor from redox reactions before assembly of the complex; soluble protein of the mitochondrial matrix; respiratory defect of null mutant is functionally complemented by Drosophila and human orthologs" /db_xref="GeneID:852572" /db_xref="SGD:S000000473" ORIGIN 1 mlcaikstgy ryprtgalnl lrgrpfnmat rkitteripg ppklpreeqe eferlqriat 61 sqeaidqyna qatgdrtkes lnsplltknd igsfspefsk tipefegdvn pktgevggpk 121 qdplrhgdys fngrvtdf // LOCUS NP_009829 545 aa linear PLN 30-JUN-2025 DEFINITION Bit2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009829 VERSION NP_009829.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178618.2 REFERENCE 1 (residues 1 to 545) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 545) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 545) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 545) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07386. On Apr 26, 2011 this sequence version replaced NP_009829.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..545 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..545 /product="Bit2p" /calculated_mol_wt="61088" Region 326..482 /region_name="HbrB" /note="HbrB-like; pfam08539" /db_xref="CDD:430059" CDS 1..545 /gene="BIT2" /locus_tag="YBR270C" /coded_by="NM_001178618.2:1..1638" /experiment="EXISTENCE:curator inference:GO:0038203 TORC2 signaling [PMID:15689497]" /experiment="EXISTENCE:direct assay:GO:0031932 TORC2 complex [PMID:15689497]" /note="Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; BIT2 has a paralog, BIT61, that arose from the whole genome duplication" /db_xref="GeneID:852573" /db_xref="SGD:S000000474" ORIGIN 1 matdlnrkrs atsgslsvtn pnikatnrkp arvysvssdi vpqalthpde dvhlktsksp 61 hdaaprwsqv gfqsifhdgs narrstdsie eeysqgtenn dghseigsss snrmegntts 121 ndslfssnsr gnkrrlsift nskdnmrnrs rsgsknygtv itgtssnnis rsgsklfhtk 181 snmsvnslqs slstghshsn kgsnvfskma kkllpykphn sigkddvepv vpspfskflh 241 ssygkhrspv qfihtstggl idsgksvysf npsinnnpnd talsliqdda fdatnvsllh 301 dllknlpsli anyksftvqe lfvlegniwg iycsivvelf knkrvwqlpa kiedidrlle 361 fyitlktqtk aavthsrfla eieefittsl yilenqivfn yanedtvnta lkrvgiiwkv 421 fyqqvyydmm avllpfeksf qknsnywldg ylsepsryap sidvlllkcf rdsiilpyye 481 sflhtndgas ksfqryifse eeqngvteed kltllqcfgi lntikgnsrn qriigelleg 541 irmsi // LOCUS NP_009830 419 aa linear PLN 30-JUN-2025 DEFINITION S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009830 VERSION NP_009830.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178619.3 REFERENCE 1 (residues 1 to 419) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 419) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 419) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 419) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 419) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 419) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 419) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07387. On Jul 30, 2012 this sequence version replaced NP_009830.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..419 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..419 /product="S-adenosylmethionine-dependent methyltransferase" /calculated_mol_wt="47846" Region 213..>344 /region_name="AdoMet_MTases" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl17173" /db_xref="CDD:473071" Site order(260..266,290..291,316..318,341) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..419 /gene="EFM2" /locus_tag="YBR271W" /coded_by="NM_001178619.3:1..1260" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:21858014]" /experiment="EXISTENCE:direct assay:GO:0016279 protein-lysine N-methyltransferase activity [PMID:25086354]" /experiment="EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:22522802]" /experiment="EXISTENCE:mutant phenotype:GO:0045905 positive regulation of translational termination [PMID:25231983]" /note="S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which dimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 613 and methylates EF3 (Yef3p) at lysine 187; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; involved in regulation of translational termination; predicted involvement in ribosome biogenesis" /db_xref="GeneID:852574" /db_xref="SGD:S000000475" ORIGIN 1 mfdpldlytp ddiqvealqf nlaerepkdp cspqrdeilt avdeeesddd dtiidnldlp 61 svkyappevi lcilillkpd rqvnfnqetg knksvlevck shglepdllk rlltwyteew 121 pnkrlnslek icnkipmlrf tvskelllgy ytsvlkkynn scglneeiiq ellkelssri 181 sencgrtaqp sivryfelrn lstsiplhep sltadnlgwk twgsslilsq lvvdhldylh 241 ttnvnmlans dikqikvlel gagtglvgls walkwkelyg tenieifvtd lpeivtnlkk 301 nvslnnlgdf vqaeildwtn phdfidkfgh enefdvilia dpiyspqhpe wvvnmiskfl 361 aasgtchlei plrakyaker evlklllkes dlkvveerhs egvddwgavk ylyrqivrn // LOCUS NP_009831 480 aa linear PLN 30-JUN-2025 DEFINITION Hsm3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009831 VERSION NP_009831.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178620.3 REFERENCE 1 (residues 1 to 480) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 480) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 480) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 480) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07388. On Jul 30, 2012 this sequence version replaced NP_009831.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..480 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..480 /product="Hsm3p" /calculated_mol_wt="55412" Region 9..465 /region_name="Hsm3_like" /note="Hsm3 is a yeast Proteasome chaperone of the 19S regulatory particle and related proteins; cd12794" /db_xref="CDD:240614" Site order(30..31,34,38..39,42..43,75,148,150,167,170,190, 210..211,232,235..236,252..255,258,424..427,438,459, 462..465) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:240614" Site order(150..151,153..154,157,190,194..195,198,231..232,236, 283..287,290) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:240614" CDS 1..480 /gene="HSM3" /locus_tag="YBR272C" /coded_by="NM_001178620.3:1..1443" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19446323]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:19446323]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:19412159]" /experiment="EXISTENCE:genetic interaction:GO:0070682 proteasome regulatory particle assembly [PMID:19446323|PMID:19412159|PMID:19446322]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:10681183]" /experiment="EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19446322|PMID:19217412|PMID:19446323]" /note="Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation; ortholog of human 19S subunit S5b" /db_xref="GeneID:852575" /db_xref="SGD:S000000476" ORIGIN 1 mseketnyve nlltqlenel nednlpedin tllrkcslnl vtvvslpdmd vkpllatikr 61 fltsnvsyds lnydylldvv dklvpmadfd dvlevysaed lvkalrseid plkvaacrvi 121 ensqpkglfa tsniidilld ilfdekvend klitaiekal erlstdelir rrlfdnnlpy 181 lvsvkgrmet vsfvrlidfl tiefqfisgp efkdiifcft keeilksved ilvfielvny 241 ytkflleirn qdkywalrhv kkilpvfaql fedtenypdv rafstncllq lfaevsriee 301 deyslfktmd kdslkigsea klitewleli npqylvkyhk dvvenyfhvs gysigmlrnl 361 sadeecfnai rnkfsaeivl rlpyleqmqv vetltryeyt skfllnempk vmgsligdgs 421 agaiidletv hyrnsalrnl ldkgeeklsv wyepllreys kavngknyst gsetkiadcr // LOCUS NP_009832 436 aa linear PLN 30-JUN-2025 DEFINITION Ubx7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009832 VERSION NP_009832.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178621.1 REFERENCE 1 (residues 1 to 436) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 436) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 436) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 436) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07389. Method: conceptual translation. FEATURES Location/Qualifiers source 1..436 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..436 /product="Ubx7p" /calculated_mol_wt="49900" Region 213..292 /region_name="UBX" /note="UBX domain; pfam00789" /db_xref="CDD:395637" CDS 1..436 /gene="UBX7" /locus_tag="YBR273C" /gene_synonym="CUI3" /coded_by="NM_001178621.1:1..1311" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14755638]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:14755638]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:14755638]" /note="UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p; UBX7 has a paralog, UBX6, that arose from the whole genome duplication" /db_xref="GeneID:852576" /db_xref="SGD:S000000477" ORIGIN 1 mlealfrdsv eeaindsike gvvlavynta rddqwlkswf kgddvsldtl aehsiwlrlv 61 kdteqfqlfe qvfpnvvvps iyliragkie liiqgeddrh wekllacigi kdkkagesss 121 retnpglare ekssrdvhrk nareriaett leiqrreqlk qrklaeeere riirlvradr 181 aerkaldeth hrtldddkpl dvhdyikdaq klhsskcvlq irmtdgktlk hefnssetln 241 dvrkwvdvnr tdgdcpysfh rgiprvtfkd sdelktletl eltprsalll kpletqnsgl 301 svtgmegpsl lgrlykgfst wwhndkdpev tsqreetskp nrhevrsstp lsgaassscf 361 qynnvrepvq ssahaspmlt psgtrypset nlttsrsvsp nvfqfvnndh qedpedpttf 421 ngnnvhlekk kdedkk // LOCUS NP_009833 527 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase CHK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009833 VERSION NP_009833.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178622.1 REFERENCE 1 (residues 1 to 527) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 527) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 527) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 527) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07390. Method: conceptual translation. FEATURES Location/Qualifiers source 1..527 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..527 /product="serine/threonine protein kinase CHK1" /EC_number="2.7.11.1" /calculated_mol_wt="59886" Region 13..281 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(21..24,27,29,43,45,79,95..98,142,146..147,149, 159..160) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270971" CDS 1..527 /gene="CHK1" /locus_tag="YBR274W" /coded_by="NM_001178622.1:1..1584" /experiment="EXISTENCE:direct assay:GO:0000077 DNA damage checkpoint signaling [PMID:11390356]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:11390356]" /experiment="EXISTENCE:genetic interaction:GO:0031297 replication fork processing [PMID:18593882]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:10660074]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:11390356]" /note="Serine/threonine kinase and DNA damage checkpoint effector; mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase" /db_xref="GeneID:852577" /db_xref="SGD:S000000478" ORIGIN 1 mslsqvsplp hikdvvlgdt vgqgafacvk nahlqmdpsi ilavkfihvp tckkmglsdk 61 ditkevvlqs kcskhpnvlr lidcnvskey mwiilemadg gdlfdkiepd vgvdsdvaqf 121 yfqqlvsain ylhvecgvah rdikpenill dkngnlklad fglasqfrrk dgtlrvsmdq 181 rgsppymape vlyseegyya drtdiwsigi llfvlltgqt pwelpslene dfvffiendg 241 nlnwgpwski efthlnllrk ilqpdpnkrv tlkalklhpw vlrrasfsgd dglcndpell 301 akklfshlkv slsnenylkf tqdtnsnnry istqpignel aelehdsmhf qtvsntqraf 361 tsydsntnyn sgtgmtqeak wtqfisydia alqfhsdend cnelvkrhlq fnpnkltkfy 421 tlqpmdvllp ilekalnlsq irvkpdlfan ferlcellgy dnvfpliini ktksnggyql 481 cgsisiikie eelksvgfer ktgdplewrr lfkkisticr diilipn // LOCUS NP_009834 1916 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding protein RIF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009834 VERSION NP_009834.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178623.4 REFERENCE 1 (residues 1 to 1916) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1916) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1916) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1916) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1916) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1916) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1916) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07391. On Jul 30, 2012 this sequence version replaced NP_009834.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1916 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1916 /product="DNA-binding protein RIF1" /calculated_mol_wt="217800" Region 241..649 /region_name="Rif1_N" /note="Rap1-interacting factor 1 N terminal; pfam12231" /db_xref="CDD:463499" Region 1862..1907 /region_name="Rif1_CTD_C-II_like" /note="Saccharomyces cerevisiae Rap1-interacting factor 1 CTD domain, metazoan Rif1 C-II domains and related domains; cd14267" /db_xref="CDD:341312" Site order(1862..1865,1867..1868,1870..1872,1874..1880, 1882..1887,1889..1907) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:341312" Site order(1862..1865,1867..1868,1870..1872,1874..1880, 1882..1887,1889..1891,1893..1895,1897..1899,1901..1902, 1904..1906) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:341312" Site order(1892,1895..1896,1899..1900,1902..1903,1906..1907) /site_type="other" /note="interdimer interface [polypeptide binding]" /db_xref="CDD:341312" CDS 1..1916 /gene="RIF1" /locus_tag="YBR275C" /coded_by="NM_001178623.4:1..5751" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:9710643]" /experiment="EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:30104203]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:30104203]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:30104203]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:17656141]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:24532715]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:1577274]" /experiment="EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:24692507]" /experiment="EXISTENCE:mutant phenotype:GO:0016233 telomere capping [PMID:20523746]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:1577274]" /experiment="EXISTENCE:mutant phenotype:GO:0032297 negative regulation of DNA-templated DNA replication initiation [PMID:27820830]" /experiment="EXISTENCE:mutant phenotype:GO:0070198 protein localization to chromosome, telomeric region [PMID:29529242]" /experiment="EXISTENCE:mutant phenotype:GO:0097752 regulation of DNA stability [PMID:27820830]" /experiment="EXISTENCE:mutant phenotype:GO:0101018 negative regulation of mitotic DNA replication initiation from late origin [PMID:27820830]" /experiment="EXISTENCE:physical interaction:GO:0006270 DNA replication initiation [PMID:24532715]" /experiment="EXISTENCE:physical interaction:GO:0070187 shelterin complex [PMID:23746845]" /note="Protein involved in control of DNA replication; binds Rap1p C-terminus, telomeres, centromeres, replication origins; contributes to resection of DNA double strand breaks (DSBs); acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; in addition to controlling DNA replication initiation, plays ongoing role after initiation and controls events at blocked replication forks" /db_xref="GeneID:852578" /db_xref="SGD:S000000479" ORIGIN 1 mskdfsdkkk htidridqhi lrrsqhdnys ngsspwmktn lpppspqahm hiqsdlsptp 61 krrklasssd cenkqfdlsa inknlypedt gsrlmqslpe lsasnsdnvs pvtksvafsd 121 riesspiyri pgsspkpsps skpgksilrn rlpsvrtvsd lsynklqytq hklhngnift 181 spyketrvnp raleywvsge ihglvdnesv sefkeiiegg lgilrqesed yvarrfevya 241 tfnniipilt tknvnevdqk fnilivnies iieiciphlq iaqdtllsss ekknpfvirl 301 yvqivrffsa imsnfkivkw ltkrpdlvnk lkviyrwttg alrnensnki iitaqvsflr 361 dekfgtffls neeikpiist fteimeinsh nliyekllli rgflskypkl mietvtswlp 421 gevlpriiig deiysmkili tsivvllell kkcldfvdeh eriyqcimls pvcetipekf 481 lsklplnsyd sanldkvtig hlltqqikny ivvkndnkia mdlwlsmtgl lydsgkrvyd 541 ltsesnkvwf dlnnlcfinn hpktrlmsik vwriitycic tkisqknqeg nksllsllrt 601 pfqmtlpyvn dpsaregiiy hllgvvytaf tsnknlstdm felfwdhlit piyedyvfky 661 dsihlqnvlf tvlhlliggk nadvalerky kkhihpmsvi asegvklkdi sslppqiikr 721 eydkimkvvf qavevaisnv nlahdlilts lkhlpedrkd qthlesfssl ilkvtqnnkd 781 tpifrdffga vtssfvytfl dlflrkndss lvnfniqisk vgisqgnmtl dllkdvirka 841 rnetseflii ekflelddkk tevyaqnwvg stllppnisf refqslaniv nkvpnensie 901 nfldlclkls fpvnlftllh vsmwsnnnfi yfiqsyvskn enklnvdlit llktslpgnp 961 elfsgllpfl rrnkfmdile ycihsnpnll nsipdlnsdl llkllprsra syfaaniklf 1021 kcseqltlvr wllkgqqleq lnqnfseien vlqnasdsel ekseiirell hlamanpiep 1081 lfsgllnfci knnmadhlde fcgnmtsevl fkispelllk lltykekpng kllaavieki 1141 engdddyile llekiiiqke iqileklkep llvfflnpvs snmqkhkkst nmlrelvlly 1201 ltkplsrsaa kkffsmlisi lppnpnyqti dmvnllidli kshnrkfkdk rtynatlkti 1261 gkwiqesgvv hqgdsskeie aipdtksmyi pcegsenkls nlqrkvdsqd iqvpatqgmk 1321 eppssiqiss qisakdsdsi slkntaimns sqqeshanrs rsiddetlee vdnesireid 1381 qqmkstqldk nvanhsnics tksdevdvte lhesidtqss evnayqpiev ltselkavtn 1441 rsiktnpdhn vvnsdnplkr psketptsen krskghetmv dvlvseeqav spssdvictn 1501 iksianeess lalrnsikve tncnenslnv tldldqqtit kedgkgqveh vqrqenqesm 1561 nkinsksftq dniaqyksvk karpnnegen ndyacnveqa spvrnevpgd giqipsgtil 1621 lnsskqteks kvddlrsded ehgtvaqekh qvgainsrnk nndrmdstpi qgteeesrev 1681 vmteeginvr ledsgtceln knlkgplkgd kdaninddfv pveenvrdeg flksmehavs 1741 ketgleeqpe vadisvlpei ripifnslkm qgsksqikek lkkrlqrnel mppdspprmt 1801 entninaqng ldtvpktigg kekhheiqlg qahteadgep llggdgneda tsreatpslk 1861 vhffskksrr lvarlrgftp gdlngisvee rrnlrielld fmmrleyysn rdndmn // LOCUS NP_009835 807 aa linear PLN 30-JUN-2025 DEFINITION tyrosine/serine/threonine protein phosphatase PPS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009835 VERSION NP_009835.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178624.3 REFERENCE 1 (residues 1 to 807) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 807) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 807) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 807) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07392. On Jul 30, 2012 this sequence version replaced NP_009835.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..807 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..807 /product="tyrosine/serine/threonine protein phosphatase PPS1" /EC_number="3.1.3.16" /EC_number="3.1.3.48" /calculated_mol_wt="91554" Region 580..779 /region_name="DSP_fungal_PPS1" /note="dual specificity phosphatase domain of fungal dual specificity protein phosphatase PPS1-like; cd14516" /db_xref="CDD:350366" CDS 1..807 /gene="PPS1" /locus_tag="YBR276C" /coded_by="NM_001178624.3:1..2424" /experiment="EXISTENCE:direct assay:GO:0008138 protein tyrosine/serine/threonine phosphatase activity [PMID:9083070]" /experiment="EXISTENCE:mutant phenotype:GO:0033260 nuclear DNA replication [PMID:9083070]" /note="Protein phosphatase; has specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle" /db_xref="GeneID:852579" /db_xref="SGD:S000000480" ORIGIN 1 mvlevpsitp gelhdlmrlh qdaewpeckk mfpwahdisf gqppdfphsl aivksqsdan 61 nsallrnsle vndifqswkv rtsfhregdt cetgndsngf qypnntkell nllkfqirql 121 elqvddvale naatychnhs ilpflkvdpr glslelkrys rnkvgsnttl krsgqdvwgr 181 rglfrrfdlq cakmiemvdn iviycsrtgg stdmqtesap acshegncpn cttlalllqi 241 clmfvqkgyv gsggslyktn lfictyqnfn tdipqtligt plldneffkn ntplnlcssp 301 seivcfnnvd knmvlcekle lnkltsatrl eetglicgnt tdwhnyqiik knnislthrf 361 eentsivnlk slnydtdnpt tsisqlynip ntkevwklii kctsnsqmps ltkirtyldl 421 lldddasksq ehlhltfpas gsiglgnlni qsveillnvc ylifqvsqvq elltfmyced 481 gytetslllt ayiifhfnip lqdallrihp rpfflfpsdl qilghlqpvl refspqngsn 541 lklyanalkf rdksfqlhis selfssiffm kiplesnfvn lkgplpsril rhlylgsldh 601 aqnpallksl githivsvge vvswtlnkdk iahpvrphra itmtntneva gnttcnksrn 661 radtvvsdkq engsnvvise nsgfqicqie nlddngkdpl fhqidkvldf isnseatggk 721 vlvhcmvgvs rsatvciaec mrylqcdlas aylfvrvrrl nviiqpnlff vyelfkwwkk 781 hynrekdktm dwhiicrgia evnmkyt // LOCUS NP_009837 201 aa linear PLN 30-JUN-2025 DEFINITION DNA polymerase epsilon noncatalytic subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_009837 VERSION NP_009837.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178626.1 REFERENCE 1 (residues 1 to 201) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 201) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 201) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 201) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07393. Method: conceptual translation. FEATURES Location/Qualifiers source 1..201 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..201 /product="DNA polymerase epsilon noncatalytic subunit" /calculated_mol_wt="22534" Region 9..91 /region_name="HFD_POLE4-like" /note="histone-fold domain found in DNA polymerase epsilon subunit 4 (POLE4) and similar proteins; cd22929" /db_xref="CDD:467054" Site order(9,16,20,23..24,26..31,33..34,36..38,40..51,64..65, 69..71,83,86..87,90) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467054" Site order(23,25,33,44,47..48,51,55,58..59,80..83,85..86,89..90) /site_type="other" /note="catalytic subunit binding site [polypeptide binding]" /db_xref="CDD:467054" CDS 1..201 /gene="DPB3" /locus_tag="YBR278W" /coded_by="NM_001178626.1:1..606" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:14622139|PMID:16916794]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:14622139|PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0008622 epsilon DNA polymerase complex [PMID:12571237|PMID:2406268]" /experiment="EXISTENCE:direct assay:GO:0030337 DNA polymerase processivity factor activity [PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:19776424]" /experiment="EXISTENCE:genetic interaction:GO:0006272 leading strand elongation [PMID:21124948]" /experiment="EXISTENCE:genetic interaction:GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity [PMID:21124948]" /experiment="EXISTENCE:genetic interaction:GO:0030337 DNA polymerase processivity factor activity [PMID:21124948]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:1923754]" /experiment="EXISTENCE:mutant phenotype:GO:0006272 leading strand elongation [PMID:21124948]" /note="Third-largest subunit of DNA polymerase II (DNA polymerase epsilon); required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; mRNA abundance peaks at the G1/S boundary of the cell cycle; DPB3 has a paralog, DLS1, that arose from the whole genome duplication" /db_xref="GeneID:852580" /db_xref="SGD:S000000482" ORIGIN 1 msnlvkekap vfpiskvkki akcdpeyvit snvaisataf aaelfvqnlv eeslvlaqln 61 skgktslrls lnsieecvek rdnfrfleda ikqlkknsal dkkrelnmqp grsdqevvie 121 epelheddgv eeeeeedevs eeeepvhnee llddskdqqn dkstrsvasl lsrfqyksal 181 dvgehsdssd ievdhtkstd p // LOCUS NP_009838 445 aa linear PLN 30-JUN-2025 DEFINITION Paf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009838 VERSION NP_009838.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178627.1 REFERENCE 1 (residues 1 to 445) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 445) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 445) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 445) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07394. Method: conceptual translation. FEATURES Location/Qualifiers source 1..445 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..445 /product="Paf1p" /calculated_mol_wt="51670" Region 8..415 /region_name="Paf1" /note="pfam03985" /db_xref="CDD:397885" CDS 1..445 /gene="PAF1" /locus_tag="YBR279W" /coded_by="NM_001178627.1:1..1338" /experiment="EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:11983171]" /experiment="EXISTENCE:direct assay:GO:0001015 snoRNA transcription by RNA polymerase II [PMID:16246725]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11983171]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15149594|PMID:15643076]" /experiment="EXISTENCE:direct assay:GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding [PMID:22796944]" /experiment="EXISTENCE:direct assay:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:20299458]" /experiment="EXISTENCE:genetic interaction:GO:0006360 transcription by RNA polymerase I [PMID:20299458]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:11927560]" /experiment="EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:21737840]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10219085]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15180994]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:16582434]" /experiment="EXISTENCE:mutant phenotype:GO:0001015 snoRNA transcription by RNA polymerase II [PMID:16246725]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10219085|PMID:11884586]" /experiment="EXISTENCE:mutant phenotype:GO:0006360 transcription by RNA polymerase I [PMID:20299458]" /experiment="EXISTENCE:mutant phenotype:GO:0006362 transcription elongation by RNA polymerase I [PMID:19164765]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:20299458]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:11927560]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:31501524]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:15149594]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:16246725]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:14710186]" /experiment="EXISTENCE:mutant phenotype:GO:0045910 negative regulation of DNA recombination [PMID:9891041]" /experiment="EXISTENCE:mutant phenotype:GO:0070911 global genome nucleotide-excision repair [PMID:21737840]" /experiment="EXISTENCE:mutant phenotype:GO:1901525 negative regulation of mitophagy [PMID:31525119]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:16581788]" /experiment="EXISTENCE:physical interaction:GO:0016593 Cdc73/Paf1 complex [PMID:11884586|PMID:11927560|PMID:9032243]" /note="Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1" /db_xref="GeneID:852582" /db_xref="SGD:S000000483" ORIGIN 1 mskkqeyiap ikyqnslpvp qlppkllvyp espetnadss qlinslyikt nvtnliqqde 61 dlgmpvdlmk fpgllnklds kllygfdnvk ldkddrillr dpridrltkt diskvtflrr 121 teyvsntiaa hdntslkrkr rlddgdsdde nldvnhiisr vegtfnktdk wqhpvkkgvk 181 mvkkwdllpd tasmdqvyfi lkfmgsasld tkekkslntg ifrpveleed ewismyatdh 241 kdsailenel ekgmdemddd shegkiykfk rirdydmkqv aekpmtelai rlndkdgiay 301 ykplrskiel rrrrvndiik plvkehdidq lnvtlrnpst keanirdklr mkfdpinfat 361 vdeeddedee qpedvkkese gdsktegseq egenekdeei kqekeneqde enkqdenraa 421 dtpetsdavh teqkpeeeke tlqee // LOCUS NP_009839 637 aa linear PLN 30-JUN-2025 DEFINITION SCF ubiquitin ligase complex subunit SAF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009839 VERSION NP_009839.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178628.3 REFERENCE 1 (residues 1 to 637) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 637) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 637) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 637) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07395. On Jul 30, 2012 this sequence version replaced NP_009839.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..637 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..637 /product="SCF ubiquitin ligase complex subunit SAF1" /calculated_mol_wt="70365" Region 15..60 /region_name="F-box_SF" /note="F-box domain superfamily; cl45894" /db_xref="CDD:459239" Site order(15..16,18..20,23..24,27,38..40,42,45) /site_type="other" /note="F-box motif" /db_xref="CDD:438852" Site order(15,19,22..23,26..27,31,33..34,38..40,42) /site_type="other" /note="Skp1 binding site [polypeptide binding]" /db_xref="CDD:438852" Region 367..>583 /region_name="ATS1" /note="Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5184" /db_xref="CDD:444065" Region 546..>632 /region_name="ATS1" /note="Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5184" /db_xref="CDD:444065" Region 548..579 /region_name="RCC1_2" /note="Regulator of chromosome condensation (RCC1) repeat; pfam13540" /db_xref="CDD:463914" CDS 1..637 /gene="SAF1" /locus_tag="YBR280C" /coded_by="NM_001178628.3:1..1914" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:19882662|PMID:11283612]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:17517885]" /experiment="EXISTENCE:mutant phenotype:GO:0019005 SCF ubiquitin ligase complex [PMID:17517885]" /experiment="EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:16677311|PMID:17517885]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:17517885]" /note="F-Box protein involved in proteasome-dependent degradation of Aah1p; involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1" /db_xref="GeneID:852583" /db_xref="SGD:S000000484" ORIGIN 1 msevesreke pdaglspdiv qatlpflssd diknlsqtnk yyntlldfdh skilwhelfh 61 kafgtlktnd epfqgrnsae fktctetilr eafptlswqe vyqlraydak fyswgylkhg 121 rlgytassnn elvatslngp sprfkygvnt ptevpwfnsr ttsrtsnftp sedplsaikk 181 dgdeiiaqvs sggfsfqilt esgnlyssgs tfsgglkgpg psgsqhdynp fremihnmer 241 sypritsrsn gstvnttgtf sgrrmsgshp stayepgnat taqhitidsg gapaaspggs 301 hsgvprttmp smgpheniys qiemlersan kavpgnnhir rmfarnsfpl ysgrdenlgs 361 fndiqfvavs sgrshflamd tdnniyswds tesdqgvkie fanlpsratn pilkiasgwn 421 fnccyiykvg lvawkerdai qkgesfafak yeivpntndv ngdsrivdfa clqdncvffi 481 nnngdklwky hnglnqivdl nivgklckin acfaslvlft dthcytlkvt ngdvdkdslt 541 eldinenvis vasgdyhtva lterghlysw giesqdcgcl glgpsekivn elhignwegq 601 rnirvvkptk ielpedyicv svtaggwqtg aliikkh // LOCUS NP_009840 878 aa linear PLN 30-JUN-2025 DEFINITION glutamine amidotransferase subunit DUG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009840 VERSION NP_009840.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178629.3 REFERENCE 1 (residues 1 to 878) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 878) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 878) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 878) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 878) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 878) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 878) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07396. On Jul 30, 2012 this sequence version replaced NP_009840.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..878 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..878 /product="glutamine amidotransferase subunit DUG2" /calculated_mol_wt="97940" Region 19..336 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(19,37,41,47..48,67..68,87,91,97..98,110..111,140,145, 151..152,189,194,210..211,221..222,254,258,264..265, 275..276,301,306,312..313,326..327) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 23..60 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 74..121 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 126..158 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 166..213 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 226..280 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 288..324 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 343..372 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 437..878 /region_name="M20_dipept_like_DUG2_type" /note="M20 Defective in Utilization of Glutathione-type peptidases containing WD repeats; cd05677" /db_xref="CDD:349926" Site order(631,635,637,641..646,648..654,660..662,664,667..668, 671,704,714,717..718,723..730,733..740,747,749,751, 823..824,852..855) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:349926" CDS 1..878 /gene="DUG2" /locus_tag="YBR281C" /coded_by="NM_001178629.3:1..2637" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17179087|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006751 glutathione catabolic process [PMID:22277648]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0036374 glutathione hydrolase activity [PMID:22277648]" /experiment="EXISTENCE:direct assay:GO:0061672 glutathione hydrolase complex [PMID:22277648]" /experiment="EXISTENCE:genetic interaction:GO:0008233 peptidase activity [PMID:17179087]" /experiment="EXISTENCE:genetic interaction:GO:0008242 omega peptidase activity [PMID:17179087]" /experiment="EXISTENCE:mutant phenotype:GO:0006751 glutathione catabolic process [PMID:17179087|PMID:22277648]" /note="Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" /db_xref="GeneID:852584" /db_xref="SGD:S000000485" ORIGIN 1 mydsrgvalh selihrwnha fsilsivafp kkrllfagsq dskilvfdlp tynlihtirl 61 gesqeethtr ssvlcltgse denflfsgga dslvriwsig ektirddflp vteiatvysv 121 tdigdifsla yldsletivf gcqnasllyv enliqkiekk ssdgvenink lphrrydkff 181 dslgptgyss nslsqtslts lqencgaaii evpseniiky ahygfiysin klcprfnqll 241 ekssrtsgae hiissagdgi sklwefskdk gqntvkisli ndkidnedsv isqtiefpfl 301 ycgltdgiik iwdlntqqii stlktkhesd visisvymdh vfaidesgit hfyqnqvnhw 361 npqqgkilss eifsksnags vslltggsdg sltlwditsl lsavplssns pinasstlqt 421 tnlwaayqsa slnneemlnt lrelisfqtv sqskdttntl slrrcaiylq qlflkfgatn 481 sqlfplpdgg npvvfayfqg ngkvsqvkga kkkrilwygh ydvissgntf nwntdpftlt 541 cengylkgrg vsdnkgplvs aihsvaylfq qgelvndvvf lvegseeigs aslkqvceky 601 hdiigkdidw illsnstwvd qehpclnygl rgvinaqikv wsdkpdghsg lnggvydepm 661 vnlvkivskl qneqneimip nfysplkdlt eeeyqrfqki telanident tvqdlitnwt 721 kpslsmttvk fsgpgnitvi pksvtmgisi rlvpeqsveq vkrdlkayle esfkqlksqn 781 hleikvlnea egwlgdptnh ayqilkdeit tawdvepllv reggsisclr mlerifdapa 841 vqipcgqstd nghlanenlr iknwsnltei lskvfnrl // LOCUS NP_009841 146 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL41 MRPL27 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009841 VERSION NP_009841.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178630.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 146) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07397. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..146 /product="mitochondrial 54S ribosomal protein mL41 MRPL27" /calculated_mol_wt="16361" Region 35..131 /region_name="MRP-L27" /note="Mitochondrial ribosomal protein L27; pfam09809" /db_xref="CDD:286847" CDS 1..146 /gene="MRPL27" /locus_tag="YBR282W" /gene_synonym="mL41" /coded_by="NM_001178630.1:1..441" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP" /db_xref="GeneID:852585" /db_xref="SGD:S000000486" ORIGIN 1 mkgspisqfs ktsinaltrp wkkyrdgelf yglskvgnkr vplttkqgnk tmykgtrasg 61 igrhtkfggy vinwkkvrty vtpdmvnfel kpyvnanvpp lkhefkgfsg gpldprlqll 121 kikeyivngr vqsegatdts cykerg // LOCUS NP_009842 490 aa linear PLN 30-JUN-2025 DEFINITION Ssh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009842 VERSION NP_009842.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178631.1 REFERENCE 1 (residues 1 to 490) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 490) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 490) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 490) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07398. Method: conceptual translation. FEATURES Location/Qualifiers source 1..490 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..490 /product="Ssh1p" /calculated_mol_wt="53181" Region 1..472 /region_name="PTZ00219" /note="Sec61 alpha subunit; Provisional" /db_xref="CDD:185519" CDS 1..490 /gene="SSH1" /locus_tag="YBR283C" /coded_by="NM_001178631.1:1..1473" /experiment="EXISTENCE:direct assay:GO:0005048 signal sequence binding [PMID:12134063]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071261 Ssh1 translocon complex [PMID:8612571]" /experiment="EXISTENCE:genetic interaction:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:18347066|PMID:11702951]" /experiment="EXISTENCE:mutant phenotype:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:11702951]" /note="Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential" /db_xref="GeneID:852586" /db_xref="SGD:S000000487" ORIGIN 1 msgfrlidiv kpilpilpev elpfeklpfd dkivytifag liylfaqfpl vglpkattpn 61 vndpiyflrg vfgceprtll efglfpniss glilqllagl kvikvnfkiq sdrelfqslt 121 kvfaivqyvi ltnififagy fgddlsvvqi glinfqlvga gifttllaev idkgfgfssg 181 amiintvvia tnlvadtfgv sqikvgeddq teaqgalinl iqglrskhkt figgiisafn 241 rdylpnlttt iivlaiaiiv cylqsvrvel pirstrargt nnvypiklly tgclsvlfsy 301 tilfyihifa fvliqlvakn epthiickim ghyenannll avptfplsll apptsffkgv 361 tqqpltfity safilvtgiw fadkwqaisg ssardvalef kdqgitlmgr reqnvakeln 421 kvipiaavtg asvlslitvi geslglkgka agivvgiagg fsllevitie yqqsggqsal 481 nqvlgvpgam // LOCUS NP_009843 797 aa linear PLN 30-JUN-2025 DEFINITION metallo-dependent hydrolase superfamily protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009843 VERSION NP_009843.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178632.3 REFERENCE 1 (residues 1 to 797) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 797) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 797) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 797) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 797) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 797) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 797) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07399. On Jul 30, 2012 this sequence version replaced NP_009843.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..797 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..797 /product="metallo-dependent hydrolase superfamily protein" /calculated_mol_wt="92773" Region 219..791 /region_name="metallo-dependent_hydrolases" /note="Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; cl00281" /db_xref="CDD:469705" Site order(282,284,578,617,690) /site_type="active" /db_xref="CDD:238617" CDS 1..797 /locus_tag="YBR284W" /coded_by="NM_001178632.3:1..2394" /note="Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; null mutant exhibits longer telomeres, altered Ty mobility, decreased resistance to rapamycin and wortmannin; induced in response to hydrostatic pressure; not an essential gene; YBR284W has a paralog, YJL070C, that arose from the whole genome duplication" /db_xref="GeneID:852587" /db_xref="SGD:S000000488" ORIGIN 1 mvqnnesvff vecdsykesp stspirlddl dgndavsdqg lafdgdvgit sqarvrnpra 61 qifedsntdv vlhlddldmv plntkfdmqm emgspmampa etpppveplk tkdlayssla 121 hlpsyffeqt hfridrkcll emsklrrnyl tiskqdalsc pqlhsrvagg ylkpvkeklf 181 girhfldlee sntvnllqdg nymtelfnsq iniptfkefr edfewclkii rdrslsrfse 241 krlqylvnkf pvfqhlhske emrqskkvph kdfyncrkid lnlllsgcfs qwqltefiwt 301 klrkepdrvi hqafngshit lsqlfkvnfe etgqffnglk iiddsflewy kviylakyhl 361 vndemeihtg shgkqlryyl iaktflefdn yingeylael lktflikpqe eskyqlcqls 421 vdfqfylhyd nsdvdnwwmv fanwlnhyni fsnnirwnir isriypelyh tgkvknfqey 481 lnlifkplfn aenylhkslg pillkflsqv ssidlciqdt dnyiwknfta vsclpkdwts 541 ggdnptisqy myyvyvnltk lnhirqalhq ntftlrsscs ptsmnrtsqf sntlnfteht 601 eailnnflla cggflnaenl wnappslvyl fylsqipmvv aplnsivdsk ptmlqeqapt 661 glvlepskpy kknpfmkffe mgfkislsse silynnsytk epiieeysva asiyrlhsad 721 lcellrnsvi tsgfsstlkn kwlgvslash dyfventgfv dkwydckpnt slehnvpiir 781 rqyrsstlag ewrliia // LOCUS NP_009844 144 aa linear PLN 30-JUN-2025 DEFINITION Hab1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009844 VERSION NP_009844.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178633.4 REFERENCE 1 (residues 1 to 144) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 144) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 144) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 144) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07400. On Jul 30, 2012 this sequence version replaced NP_009844.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..144 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..144 /product="Hab1p" /calculated_mol_wt="16680" CDS 1..144 /gene="HAB1" /locus_tag="YBR285W" /coded_by="NM_001178633.4:1..435" /experiment="EXISTENCE:direct assay:GO:0005776 autophagosome [PMID:38755257]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:38755257]" /experiment="EXISTENCE:mutant phenotype:GO:0043022 ribosome binding [PMID:38755257]" /note="Autophagy receptor; highly enriched in autophagic body fractions of both rapamycin-treated and nitrogen-starved cells; binds directly to forming isolation membranes during bulk autophagy; small protein of 144 amino acid residues without any identifiable membrane-spanning regions; N-terminal 42 amino acid region contains an amphipathic helix and an Atg8-family interacting motif" /db_xref="GeneID:852588" /db_xref="SGD:S000000489" ORIGIN 1 mtifsrfsyf dslfsfkkqe pspieiiycn enngfiniks lesptddsme adisdremat 61 iltrnrnnlg kvaidkkgvn nhcidlnelk kglvanehkl dndnstrhqn tyspedsvef 121 drfddkqsri lkcstrrsyl rykk // LOCUS NP_009845 537 aa linear PLN 30-JUN-2025 DEFINITION aminopeptidase Y [Saccharomyces cerevisiae S288C]. ACCESSION NP_009845 VERSION NP_009845.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178634.1 REFERENCE 1 (residues 1 to 537) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 537) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 537) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 537) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 537) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 537) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 537) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07401. On Nov 30, 2005 this sequence version replaced NP_009845.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..537 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..537 /product="aminopeptidase Y" /EC_number="3.4.11.15" /calculated_mol_wt="60007" Region 78..506 /region_name="M28_SGAP_like" /note="M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins; cd03876" /db_xref="CDD:349873" Region 155..284 /region_name="PA_ScAPY_like" /note="Protease-associated domain containing proteins like Saccharomyces cerevisiae aminopeptidase Y (ScAPY). This group contains various PA domain-containing proteins similar to the S. cerevisiae APY, including Trichophyton rubrum leucine aminopeptidase 1(LAP1)...; cd02130" /db_xref="CDD:239045" Site 241..243 /site_type="other" /note="PA/protease or protease-like domain interface [polypeptide binding]" /db_xref="CDD:239045" Site order(314,326..327,358..359,387..388,433,436..437,453, 471..472) /site_type="active" /db_xref="CDD:349873" CDS 1..537 /gene="APE3" /locus_tag="YBR286W" /gene_synonym="APY1" /coded_by="NM_001178634.1:1..1614" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:8175799|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004177 aminopeptidase activity [PMID:8175799]" /experiment="EXISTENCE:direct assay:GO:0007039 protein catabolic process in the vacuole [PMID:8175799]" /experiment="EXISTENCE:mutant phenotype:GO:0004177 aminopeptidase activity [PMID:8175800]" /note="Vacuolar aminopeptidase Y; processed to mature form by Prb1p; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway" /db_xref="GeneID:852589" /db_xref="SGD:S000000490" ORIGIN 1 mhfslkqlav aafyatnlgs ayvipqffqe afqqeepien ylpqlnddds savaanipkp 61 hipyfmkphv eseklqdkik vddlnatawd lyrlanystp dyghptrvig skghnktmey 121 ilnvfddmqd yydvslqefe alsgkiisfn lsdaetgksf anttafalsp pvdgfvgklv 181 eipnlgceek dyasvvpprh nekqialier gkcpfgdksn lagkfgftav viydnepksk 241 eglhgtlgep tkhtvatvgv pykvgkklia nialnidysl yfamdsyvef iktqniiadt 301 khgdpdniva lgahsdsvee gpginddgsg tisllnvakq lthfkinnkv rfawwaaeee 361 gllgsnfyay nltkeenski rvfmdydmma spnyeyeiyd annkenpkgs eelknlyvdy 421 ykahhlnytl vpfdgrsdyv gfinngipag giatgaeknn vnngkvldrc yhqlcddvsn 481 lswdafitnt kliahsvaty adsfegfpkr etqkhkevdi lnaqqpqfky radflii // LOCUS NP_009846 427 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR287W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009846 VERSION NP_009846.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178635.1 REFERENCE 1 (residues 1 to 427) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 427) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 427) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 427) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07402. Method: conceptual translation. FEATURES Location/Qualifiers source 1..427 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..427 /product="uncharacterized protein" /calculated_mol_wt="47375" Region 14..413 /region_name="Mem_trans" /note="Membrane transport protein; pfam03547" /db_xref="CDD:308904" CDS 1..427 /locus_tag="YBR287W" /coded_by="NM_001178635.1:1..1284" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene" /db_xref="GeneID:852590" /db_xref="SGD:S000000491" ORIGIN 1 mvetfsfahl aylvfesvlq vviialagfw sassgllpkq sqkiisllnv dlftpclifs 61 klakslsmak ifeiaiipif fglttgisfi sgkimsrild ldkdetnfvv ansvfgnsns 121 lpvsltlsla ytlpnltwdq ipndnrdnva srgilyllif qqigqmlrws wgynklmkws 181 gentqhmpps qvqsllertp nidneelvne eqeeqellee ennrmnssfl ssssigdkiw 241 qksctvferi ranlnpplys mifavvvaai gplqrelfme dgfinntfae avtqlgsvsi 301 plilvvlgsn lypsaevfpk tvhhskllig siigrmilps cfllpiiaia vkyinvsild 361 dpiflvvgfl ltvsppaiql tqitqlneff eaemadilfw gyavlslpvs iivvsgaiyv 421 lqwanpt // LOCUS NP_009847 483 aa linear PLN 30-JUN-2025 DEFINITION Apm3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009847 VERSION NP_009847.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178636.4 REFERENCE 1 (residues 1 to 483) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 483) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 483) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 483) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07403. On Jul 30, 2012 this sequence version replaced NP_009847.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..483 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..483 /product="Apm3p" /calculated_mol_wt="54706" Region 199..482 /region_name="AP_MHD_Cterm" /note="C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); cl10970" /db_xref="CDD:472082" CDS 1..483 /gene="APM3" /locus_tag="YBR288C" /gene_synonym="YKS6" /coded_by="NM_001178636.4:1..1452" /experiment="EXISTENCE:direct assay:GO:0030123 AP-3 adaptor complex [PMID:9250663]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:17895371]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:9335339]" /note="Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway" /db_xref="GeneID:852591" /db_xref="SGD:S000000492" ORIGIN 1 mylsfyitdt knklifqyll gatapsfkhl wtrvqstcpq lledsssddy ldhsmvgrdl 61 evykyfsvin klnywclast skskgpldcf tfletidril leyfdkdkls ikkivnnydr 121 islifnccve agepnvsdml yvnkikeavp ersdlskfis stahnlqqav qlpqqrqqql 181 qqnqisrgsn slieneeivp wrtsraskhe nnelyvdlle tfhvvfekkk shlrlltgsi 241 hgivdvrsyl ndnplvavkl ntmgndigip slhdcveind gvfspsnitf ippdgkfrll 301 eysvdlssqv kqsgvrmnsi glmslhfqng lgkdsdefel slnienfkkv sqvddlkidl 361 qfnvenadpn eiaykikilr nthgrfensi imgqgqwifd kstatgtvpv lrgcieyent 421 gpnftkkvdl qtvsleysyi gqsasgiyve aidivsglti gkntklykga kyktqtgnfq 481 vrl // LOCUS NP_009848 905 aa linear PLN 30-JUN-2025 DEFINITION Snf5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009848 VERSION NP_009848.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178637.4 REFERENCE 1 (residues 1 to 905) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 905) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 905) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 905) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 905) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 905) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 905) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07404. On Jul 30, 2012 this sequence version replaced NP_009848.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..905 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..905 /product="Snf5p" /calculated_mol_wt="102412" Region 452..662 /region_name="SNF5" /note="SNF5 / SMARCB1 / INI1; pfam04855" /db_xref="CDD:428158" CDS 1..905 /gene="SNF5" /locus_tag="YBR289W" /gene_synonym="HAF4; SWI10; TYE4" /coded_by="NM_001178637.4:1..2718" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2233708|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:18644858|PMID:8159677|PMID:8127913|PMID:8016655]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:1459453]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1901413]" /experiment="EXISTENCE:genetic interaction:GO:0045991 carbon catabolite activation of transcription [PMID:14580348]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:16024655]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:1459453]" /experiment="EXISTENCE:mutant phenotype:GO:0016514 SWI/SNF complex [PMID:8159677]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1339306|PMID:3542227]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14580348]" /experiment="EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:18202364]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14580348|PMID:11865042]" /note="Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p; relocates to the cytosol under hypoxic conditions" /db_xref="GeneID:852592" /db_xref="SGD:S000000493" ORIGIN 1 mnnqpqgtns vpnsignifs nigtpsfnma qipqqlyqsl tpqqlqmiqq rhqqllrsrl 61 qqqqqqqqqt spppqthqsp ppppqqsqpi anqsatstpp pppaphnlhp qigqvplapa 121 pinlppqiaq lplatqqqvl nklrqqaiak nnpqvvnait vaqqqvqrqi eqqkgqqtaq 181 tqleqqrqll vqqqqqqqlr nqiqrqqqqq frhhvqiqqq qqkqqqqqqq hqqqqqqqqq 241 qqqqqqqqqq qqqqqqqqqq qqqqqqqqgq ipqsqqvpqv rsmsgqpptn vqptigqlpq 301 lpklnlpkyq tiqydppetk lpyptywsdk kadtdtllye qiiqrdkink ysliretngy 361 dpfsiygfsn keyisrlwht lkyyqdlknt rmksitstsq kipsasiwgn gysgygngit 421 ntttrvipqv evgnrkhyle dklkvykqam netseqlvpi rlefdqdrdr fflrdtllwn 481 kndklikied fvddmlrdyr fedatreqhi dticqsiqeq iqefqgnpyi elnqdrlggd 541 dlririkldi vvgqnqlidq fewdisnsdn cpeefaesmc qelelpgefv taiahsireq 601 vhmyhkslal lgynfdgsai edddirsrml ptitlddvyr paaeskiftp nllqisaael 661 erldkdkdrd trrkrrqgrs nrrgmlalsg tsasntsmng vhntvaagna sslppgeill 721 pdiadiprtf rtpvpstlmp ggvdvgpsve syelrnttty ksrpdrpkpv sppcyiidhi 781 pghslllsik lpgkvntkee faaapndtss gtnamlpspe slktklnsni ragvtipsip 841 npianhtvtn spnptlqpvi pggaasksvp tpslpiappv aphdseatll tnsnngssnn 901 ntqnt // LOCUS NP_009849 321 aa linear PLN 30-JUN-2025 DEFINITION Bsd2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009849 VERSION NP_009849.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178638.1 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 321) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07405. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..321 /product="Bsd2p" /calculated_mol_wt="35633" Region 106..319 /region_name="DUF2370" /note="Protein of unknown function (DUF2370); pfam10176" /db_xref="CDD:401984" CDS 1..321 /gene="BSD2" /locus_tag="YBR290W" /coded_by="NM_001178638.1:1..966" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762|PMID:23708375]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14988731]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:9115231]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:16456538]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:14988731|PMID:9988727]" /experiment="EXISTENCE:mutant phenotype:GO:0030001 metal ion transport [PMID:9115231]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:14988731]" /note="Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endocytosis of Smf1p and is itself ubiquitylated by Rsp5p; controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification" /db_xref="GeneID:852593" /db_xref="SGD:S000000494" ORIGIN 1 mpeqelligq emntlhagss tdginvgnag rtrdtqtgve geteigsdee dsiedegsss 61 ggnstterlv phqlreqaar higkigrhfn ildrlfkkrt qqssdiqqga mfdgvfsnls 121 akpdtteteg nneqdippty deaaadmaps yygmdlnnsd iyydeicieg lpvgnianll 181 wniivstsfq figflityil htshaakqgs rfglgltfig ygysmipndv tskvgknksl 241 nrmeledpne fddvrlnsqs ttqdkfeshl nhgldeekqn ipwlavfvaf lglfitlksi 301 ydyiqvkkle kkylnqsqnq a // LOCUS NP_009850 299 aa linear PLN 30-JUN-2025 DEFINITION Ctp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009850 VERSION NP_009850.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178639.1 REFERENCE 1 (residues 1 to 299) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 299) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 299) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 299) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07406. Method: conceptual translation. FEATURES Location/Qualifiers source 1..299 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..299 /product="Ctp1p" /calculated_mol_wt="32042" Region 8..101 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 104..203 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 210..298 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..299 /gene="CTP1" /locus_tag="YBR291C" /coded_by="NM_001178639.1:1..900" /experiment="EXISTENCE:direct assay:GO:0005371 tricarboxylate secondary active transmembrane transporter activity [PMID:7876161]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006843 mitochondrial citrate transmembrane transport [PMID:7876161]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:7876161]" /note="Mitochondrial inner membrane citrate transporter; member of the mitochondrial carrier family" /db_xref="GeneID:852594" /db_xref="SGD:S000000495" ORIGIN 1 msskatksdv dplhsflags lagaaeacit ypfefaktrl qlidkaskas rnplvliykt 61 aktqgigsiy vgcpafiign takagirflg fdtikdmlrd setgelsgtr gviaglgagl 121 lesvaavtpf eaiktalidd kqsatpkyhn ngrgvvrnys slvrdkgfsg lyrgvlpvsm 181 rqaanqavrl gcynkiktli qdytdspkdk plssgltflv gafsgivtvy stmpldtvkt 241 rmqsldstky sstmncfati fkeeglktfw kgatprlgrl vlsggivfti yekvlvmla // LOCUS NP_001335747 123 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR292C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335747 VERSION NP_001335747.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348892.1 REFERENCE 1 (residues 1 to 123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 123) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80267. Method: conceptual translation. FEATURES Location/Qualifiers source 1..123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..123 /product="uncharacterized protein" /calculated_mol_wt="14289" CDS 1..123 /locus_tag="YBR292C" /coded_by="NM_001348892.1:1..372" /note="hypothetical protein; conserved across S. cerevisiae strains; YBR292C is not an essential gene" /db_xref="GeneID:852595" /db_xref="SGD:S000000496" ORIGIN 1 mkfpadyhyt spfrsckysn ilhfisllli fsrvglpnyi fiflinkaan kehrvetlls 61 gnsanacklf nilksfqhlf fffqictifs isiklvllks qeygripaef siirsekkkk 121 eeq // LOCUS NP_009852 474 aa linear PLN 30-JUN-2025 DEFINITION Vba2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009852 VERSION NP_009852.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178641.3 REFERENCE 1 (residues 1 to 474) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 474) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 474) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 474) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07407. On Jul 30, 2012 this sequence version replaced NP_009852.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..474 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..474 /product="Vba2p" /calculated_mol_wt="51546" Region 1..384 /region_name="MFS" /note="Major Facilitator Superfamily; cl28910" /db_xref="CDD:475125" Site order(19,69..70,72..74,77,97,100..101,104,245,248..249, 252..254,257,285,289,342..343,347,351,367,370..371, 374..375,378) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:349949" Region <107..>249 /region_name="TRI12" /note="Fungal trichothecene efflux pump (TRI12); pfam06609" /db_xref="CDD:115279" CDS 1..474 /gene="VBA2" /locus_tag="YBR293W" /coded_by="NM_001178641.3:1..1425" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:15572352]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:15572352]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:15572352]" /experiment="EXISTENCE:mutant phenotype:GO:0015174 basic amino acid transmembrane transporter activity [PMID:15572352]" /experiment="EXISTENCE:mutant phenotype:GO:0015802 basic amino acid transport [PMID:15572352]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:15572352]" /note="Permease of basic amino acids in the vacuolar membrane" /db_xref="GeneID:852596" /db_xref="SGD:S000000497" ORIGIN 1 msisnwitta ylitstsfqp lygsfsdalg rrnclffang aftigclacg fskniymlsf 61 mraltgiggg glitlstivn sdvipsskrg ifqafqnlll gfgaicgasf ggtiassigw 121 rwcfliqvpi svissilmny yvpnqkeynr qnssifqnpg kilrdidvmg siliitgltl 181 qllylslgcs tsklswtsps vllllvgsvi illlfilher ktsaraiipm elvnssysvv 241 vlsisilvgf asyaylftlp lffqivlgds takaglrlti pslftpvgsl itgfsmskyn 301 clrlllyigi slmflgnflf lfiektspnw liglflipan lgqgitfptt lftfifmfsk 361 sdqatatstl ylfrsigsvw gvaisagviq lsfagllrsn lkglldenki kklivqlsan 421 ssyigslhge vkntviksfd eatkrahlms tllsslalil cilkdnlakp ktrr // LOCUS NP_009853 859 aa linear PLN 30-JUN-2025 DEFINITION sulfate permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_009853 VERSION NP_009853.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178642.3 REFERENCE 1 (residues 1 to 859) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 859) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 859) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 859) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07408. On Jul 30, 2012 this sequence version replaced NP_009853.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..859 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..859 /product="sulfate permease" /calculated_mol_wt="95820" Region 123..528 /region_name="Sulfate_transp" /note="Sulfate permease family; pfam00916" /db_xref="CDD:459995" Region 633..789 /region_name="STAS_SulP_like_sulfate_transporter" /note="Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042" /db_xref="CDD:132913" CDS 1..859 /gene="SUL1" /locus_tag="YBR294W" /gene_synonym="SFP2" /coded_by="NM_001178642.3:1..2580" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:7616962]" /experiment="EXISTENCE:mutant phenotype:GO:0015116 sulfate transmembrane transporter activity [PMID:7616962]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:7616962]" /experiment="EXISTENCE:mutant phenotype:GO:1902358 sulfate transmembrane transport [PMID:7616962]" /note="High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates" /db_xref="GeneID:852597" /db_xref="SGD:S000000498" ORIGIN 1 msrkssteyv hnqedadiev feseyrtyre seaaenrdgl hngdeenwkv nsskqkfgvt 61 knelsdvlyd sipayeestv tlkeyydhsi knnltaksag sylvslfpii kwfphynftw 121 gyadlvagit vgcvlvpqsm syaqiaslsp eyglyssfig afiyslfats kdvcigpvav 181 mslqtakvia evlkkypedq tevtapiiat tlcllcgiva tglgilrlgf lvelislnav 241 agfmtgsafn iiwgqipalm gynslvntre atykvvintl khlpntklda vfgliplvil 301 yvwkwwcgtf gitladryyr nqpkvanrlk sfyfyaqamr navvivvfta iswsitrnks 361 skdrpisilg tvpsglnevg vmkipdglls nmsseipasi ivlvlehiai sksfgrindy 421 kvvpdqelia igvtnligtf fhsypatgsf srsalkakcn vrtpfsgvft ggcvllalyc 481 ltdafffipk atlsaviiha vsdlltsykt twtfwktnpl dcisfivtvf itvfssieng 541 iyfamcwsca mlllkqafpa gkflgrveva evlnptvqed idavissnel pnelnkqvks 601 tvevlpapey kfsvkwvpfd hgysrelnin ttvrppppgv ivyrlgdsft yvncsrhydi 661 ifdrikeetr rgqlitlrkk sdrpwndpge wkmpdslksl fkfkrhsatt nsdlpisngs 721 sngetyekpl lkvvcldfsq vaqvdstavq slvdlrkavn ryadrqvefh fagiispwik 781 rsllsvkfgt tneeysddsi iaghssfhva kvlkddvdyt dedsristsy snyetlcaat 841 gtnlpffhid ipdfskwdv // LOCUS NP_009854 1216 aa linear PLN 30-JUN-2025 DEFINITION cation-transporting P-type ATPase PCA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009854 VERSION NP_009854.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178643.2 REFERENCE 1 (residues 1 to 1216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1216) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 1216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07409. On Apr 26, 2011 this sequence version replaced NP_009854.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..1216 /product="cation-transporting P-type ATPase PCA1" /EC_number="7.2.2.21" /calculated_mol_wt="131745" Region 413..471 /region_name="HMA" /note="Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; cd00371" /db_xref="CDD:238219" Site order(419..421,424) /site_type="metal-binding" /note="metal-binding site [ion binding]" /db_xref="CDD:238219" Region 605..1193 /region_name="ATPase-IB1_Cu" /note="copper-(or silver)-translocating P-type ATPase; TIGR01511" /db_xref="CDD:273664" CDS 1..1216 /gene="PCA1" /locus_tag="YBR295W" /gene_synonym="CAD2; PAY2" /coded_by="NM_001178643.2:1..3651" /experiment="EXISTENCE:direct assay:GO:0005839 proteasome core complex [PMID:27226596]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27226596|PMID:17107946]" /experiment="EXISTENCE:mutant phenotype:GO:0005507 copper ion binding [PMID:17107946]" /experiment="EXISTENCE:mutant phenotype:GO:0008551 P-type cadmium transporter activity [PMID:10743563|PMID:17107946]" /experiment="EXISTENCE:mutant phenotype:GO:0015691 cadmium ion transport [PMID:17107946]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:10743563]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:17107946]" /experiment="EXISTENCE:physical interaction:GO:0070628 proteasome binding [PMID:27226596]" /note="Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function" /db_xref="GeneID:852598" /db_xref="SGD:S000000499" ORIGIN 1 mkpeklfsgl gtsdgeygvv nsenisidam qdnrgechrr siemhandnl glvsqrdctn 61 rpkitpqecl seteqichhg enrtkagldv ddaetggdht nesrvdecca ekvndtetgl 121 dvdsccgdaq tggdhtnesc vdgccvrdss vmveevtgsc eavsskeqll tsfevvpsks 181 eglqsihdir ettrcntnsn qhtgkgrlci essdstlkkr sckvsrqkie vsskpeccni 241 scveriasrs cekrtfkgst nvgisgssst dslsekffse qysrmynrys silknlgcic 301 nylrtlgkes cclpkvrfcs gegaskktky syrnssgclt kkkthgdker lsndnghadf 361 vcskscctkm kdcavtstis ghssseisri vsmepienhl nleagstgte hivlsvsgms 421 ctgcesklkk sfgalkcvhg lktslilsqa efnldlaqgs vkdvikhlsk ttefkyeqis 481 nhgstidvvv pyaakdfine ewpqgvtelk iverniiriy fdpkvigard lvnegwsvpv 541 siapfschpt ievgrkhlvr vgcttalsii ltipilvmaw apqlrekist isasmvlati 601 iqfviagpfy lnalkslifs rliemdlliv lstsaayifs ivsfgyfvvg rplsteqffe 661 tssllvtlim vgrfvselar hravksisvr slqassailv dktgketein irllqygdif 721 kvlpdsript dgtvisgsse vdealitges mpvpkkcqsi vvagsvngtg tlfvklsklp 781 gnntistiat mvdeakltkp kiqniadkia syfvptiigi tvvtfcvwia vgirvekqsr 841 sdaviqaiiy aitvlivscp cviglavpiv fviasgvaak rgvifksaes ievahntshv 901 vfdktgtlte gkltvvhetv rgdrhnsqsl llgltegikh pvsmaiasyl kekgvsaqnv 961 sntkavtgkr vegtsysglk lqggncrwlg hnndpdvrka leqgysvfcf svngsvtavy 1021 aledslrada vstinllrqr gislhilsgd ddgavrsmaa rlgiessnir shatpaekse 1081 yikdivegrn cdsssqskrp vvvfcgdgtn daigltqati gvhinegsev aklaadvvml 1141 kpklnniltm itvsqkamfr vklnflwsft ynlfaillaa gafvdfhipp eyaglgelvs 1201 ilpvifvail lryaki // LOCUS NP_009855 574 aa linear PLN 30-JUN-2025 DEFINITION Pho89p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009855 VERSION NP_009855.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178644.1 REFERENCE 1 (residues 1 to 574) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 574) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 574) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 574) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07410. Method: conceptual translation. FEATURES Location/Qualifiers source 1..574 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..574 /product="Pho89p" /calculated_mol_wt="62523" Region 25..554 /region_name="PHO4" /note="Phosphate transporter family; pfam01384" /db_xref="CDD:460184" CDS 1..574 /gene="PHO89" /locus_tag="YBR296C" /gene_synonym="ITN1" /coded_by="NM_001178644.1:1..1725" /experiment="EXISTENCE:direct assay:GO:0005436 sodium:phosphate symporter activity [PMID:23216645]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0035435 phosphate ion transmembrane transport [PMID:23216645]" /experiment="EXISTENCE:mutant phenotype:GO:0005436 sodium:phosphate symporter activity [PMID:9671031]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:9671031]" /experiment="EXISTENCE:mutant phenotype:GO:0006817 phosphate ion transport [PMID:9671031]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:9671031]" /note="Plasma membrane Na+/Pi cotransporter; active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification" /db_xref="GeneID:852599" /db_xref="SGD:S000000500" ORIGIN 1 malhqfdyif aiamlfafld afnigandva nsfassissr slkywqamvl aglceflgav 61 lagarvsgti knniidssif tndpavlmlt mtsaligssc wltfataigm pvstthsivg 121 gtigagiaag gangvvwgws gvsqiiaswf iapilagaia aivfsisrfs vlevkslers 181 iknalllvgv lvfatfsilt mlivwkgspn lhlddlsete tavsivltga iasivyfiff 241 ypfyrrkvld qdwtlklidi frgpsfyfks tddippmpeg hqltidyyeg rrnlgttvsv 301 edeenkaasn sndsvknked iqevdlvrte tepetklstk qywwsllkqg pkkwpllfwl 361 vishgwtqdv ihaqvndrdm lsgdlkgmye rskfydnrve yiysvlqait aatmsfahga 421 ndvanatgpl savyviwktn tigaksevpv wvlayggval vigcwtygyn iiknlgnkmi 481 lqspsrgfsi elavaittvm atqlgiptst tqiavggiva vglcnkdlks vnwrmvawcy 541 sgwfltlpia gliagiingi ilnaprfgve yqmt // LOCUS NP_878055 39 aa linear PLN 30-JUN-2025 DEFINITION Tyc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878055 VERSION NP_878055.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184587.3 REFERENCE 1 (residues 1 to 39) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 39) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 39) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 39) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07411. On Jul 30, 2012 this sequence version replaced NP_878055.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..39 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..39 /product="Tyc1p" /calculated_mol_wt="4383" CDS 1..39 /gene="TYC1" /locus_tag="YBR296C-A" /coded_by="NM_001184587.3:1..120" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0031397 negative regulation of protein ubiquitination [PMID:29883473]" /experiment="EXISTENCE:direct assay:GO:1990948 ubiquitin ligase inhibitor activity [PMID:29883473]" /experiment="EXISTENCE:mutant phenotype:GO:0031397 negative regulation of protein ubiquitination [PMID:29883473]" /experiment="EXISTENCE:physical interaction:GO:0010997 anaphase-promoting complex binding [PMID:29883473]" /note="Inhibitor of the Anaphase-Promoting Complex/Cyclosome (APC/C); binds to APC/C and inhibits the activity of both APC/C(Cdc20) and APC/C(Cdh1); inhibits the binding of Cdc20 and Cdh1 to APC/C; overexpression results in increased sensitivity to microtubule poison; localizes to peroxisomes; originally identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; functional homolog of human MAD2L1BP (p31comet)" /db_xref="GeneID:1466451" /db_xref="SGD:S000028605" ORIGIN 1 mkvlddwfsr kfskavhgnn hgtislstls yirvhklvk // LOCUS NP_009856 468 aa linear PLN 30-JUN-2025 DEFINITION transcription factor MAL33 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009856 VERSION NP_009856.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178645.3 REFERENCE 1 (residues 1 to 468) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 468) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 468) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 468) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07412. On Jul 30, 2012 this sequence version replaced NP_009856.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..468 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..468 /product="transcription factor MAL33" /calculated_mol_wt="54063" Region 6..43 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(7,12..15,17,20,29) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(8,11,18,24,27,34) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 79..>346 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..468 /gene="MAL33" /locus_tag="YBR297W" /coded_by="NM_001178645.3:1..1407" /note="MAL-activator protein; part of complex locus MAL3; nonfunctional in genomic reference strain S288C" /db_xref="GeneID:852600" /db_xref="SGD:S000000501" ORIGIN 1 mtlvkyacdy crvrrvkcdg kkpcsrcieh nfdctyqqpl kkrgskpigt rslkyipkak 61 mfidnkscta aaeilmkvpk kvidqclrly hdnlyviwpl lsyddlhkll deeyndhyvy 121 wflvalsaan lsdlqseles eggfsftgkq lavlcmssrq qfddlsgrdi frimtyycll 181 rcfsqssdvr nsyrlcreai glvivaglhr ekayeslsfr eqqllrkvyy llllteryys 241 vyvhcvtsld ttiappqpef vtdprlslds ffemirvftv pgkcffdala testsgscte 301 dslkkiwkel htasleiepw sygyvdisfs rhwiralawk lvfqmngtkf fsnannahil 361 veiakdmldd ifltpnnlyd vhgpgipmks levanalvdi vnkydhnmkl eawnilcdvs 421 kfvfslkhcn hkmfqrfstk cqsalidlpi srplrlndds kdeddiip // LOCUS NP_009857 614 aa linear PLN 30-JUN-2025 DEFINITION maltose permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_009857 VERSION NP_009857.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178646.1 REFERENCE 1 (residues 1 to 614) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 614) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 614) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 614) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07413. Method: conceptual translation. FEATURES Location/Qualifiers source 1..614 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..614 /product="maltose permease" /calculated_mol_wt="68132" Region 74..557 /region_name="SP" /note="MFS transporter, sugar porter (SP) family; TIGR00879" /db_xref="CDD:273317" Site order(114,117..118,121,165,215..216,218..220,223,243, 246..247,250,339,342..343,357..359,381,409,413,469..470, 474,478,494,497..498,501..502,505) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..614 /gene="MAL31" /locus_tag="YBR298C" /coded_by="NM_001178646.1:1..1845" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Maltose permease; high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C" /db_xref="GeneID:852601" /db_xref="SGD:S000000502" ORIGIN 1 mkglsslinr kkdrndshld eiengvnate fnsiemeeqg kksdfdlshl eygpgslipn 61 dnneevpdll deamqdakea desergmplm talktypkaa awsllvsttl iqegydtail 121 gafyalpvfq kkygslnsnt gdyeisvswq iglclcymag eivglqmtgp svdymgnryt 181 limalfflaa fifilyfcks lgmiavgqal cgmpwgcfqc ltvsyaseic plalryyltt 241 ysnlcwafgq lfaagimkns qnkyanselg yklpfalqwi wplplavgif fapespwwlv 301 kkgridqarr slertlsgkg pekellvsme ldkikttiek eqkmsdegty wdcvkdginr 361 rrtriaclcw igqcscgasl igystyfyek agvstdtaft fsiiqyclgi aatfiswwas 421 kycgrfdlya fglafqaimf fiigglgcsd thgakmgsga llmvvaffyn lgiapvvfcl 481 vseipssrlr tktiilarna ynviqvvvtv limyqlnsek wnwgaksgff wggfclatla 541 wavvdlpeta grtfieinel frlgvparkf kstkvdpfaa akaaaaeinv kdpkedlets 601 vvdegrntss vvnk // LOCUS NP_878056 73 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YBR298C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878056 VERSION NP_878056.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184588.1 REFERENCE 1 (residues 1 to 73) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 73) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 73) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 73) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07414. Method: conceptual translation. FEATURES Location/Qualifiers source 1..73 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..73 /product="uncharacterized protein" /calculated_mol_wt="8276" CDS 1..73 /locus_tag="YBR298C-A" /coded_by="NM_001184588.1:1..222" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466452" /db_xref="SGD:S000028606" ORIGIN 1 melfipcper lkkmmlkeel rkellilrcl yhptiqimlp tlgtlgtekr kekyalslfe 61 pilncvgsak tsg // LOCUS NP_009858 584 aa linear PLN 30-JUN-2025 DEFINITION alpha-glucosidase MAL32 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009858 VERSION NP_009858.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178647.3 REFERENCE 1 (residues 1 to 584) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 584) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 584) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 584) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07415. On Jul 30, 2012 this sequence version replaced NP_009858.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..584 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..584 /product="alpha-glucosidase MAL32" /EC_number="3.2.1.20" /calculated_mol_wt="68011" Region 15..501 /region_name="AmyAc_SI_OligoGlu_DGase" /note="Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; cd11333" /db_xref="CDD:200472" Site order(29,31,33,37) /site_type="other" /note="Ca binding site [ion binding]" /db_xref="CDD:200472" Site order(68,71,108,111,158,177,181,214,276,439) /site_type="active" /db_xref="CDD:200472" Site order(214,276,349) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:200472" Region 511..583 /region_name="Malt_amylase_C" /note="Maltogenic Amylase, C-terminal domain; pfam16657" /db_xref="CDD:435493" CDS 1..584 /gene="MAL32" /locus_tag="YBR299W" /coded_by="NM_001178647.3:1..1755" /experiment="EXISTENCE:direct assay:GO:0000025 maltose catabolic process [PMID:21873635]" /experiment="EXISTENCE:direct assay:GO:0004558 alpha-1,4-glucosidase activity [PMID:20471265]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005987 sucrose catabolic process [PMID:20471265]" /experiment="EXISTENCE:direct assay:GO:0033934 glucan 1,4-alpha-maltotriohydrolase activity [PMID:20471265]" /note="Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose" /db_xref="GeneID:852602" /db_xref="SGD:S000000503" ORIGIN 1 mtisdhpete pkwwkeatiy qiypasfkds nndgwgdlkg itsklqyikd lgvdaiwvcp 61 fydspqqdmg ydisnyekvw ptygtnedcf elidkthklg mkfitdlvin hcstehewfk 121 esrssktnpk rdwffwrppk gydaegkpip pnnwksffgg sawtfdettn efylrlfasr 181 qvdlnwened crraifesav gfwldhgvdg fridtaglys krpglpdspi fdktsklqhp 241 nwgshngpri heyhqelhrf mknrvkdgre imtvgevahg sdnalytsaa ryevsevfsf 301 thvelgtspf frynivpftl kqwkeaiasn flfingtdsw attyienhdq arsitrfadd 361 spkyrkisgk lltllecslt gtlyvyqgqe igqinfkewp iekyedvdvk nnyeiikksf 421 gknskemkdf fkgiallsrd hsrtpmpwtk dkpnagftgp dvkpwfflne sfeqginveq 481 esrdddsvln fwkralqark kykelmiygy dfqfidldsd qifsftkeye dktlfaalnf 541 sgeeiefslp regaslsfil gnyddtdvss rvlkpwegri ylvk // LOCUS NP_009860 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009860 VERSION NP_009860.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178649.3 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 120) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07416. On Jul 30, 2012 this sequence version replaced NP_009860.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..120 /product="seripauperin PAU24" /calculated_mol_wt="12716" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU24" /locus_tag="YBR301W" /gene_synonym="DAN3" /coded_by="NM_001178649.3:1..363" /note="Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth" /db_xref="GeneID:852603" /db_xref="SGD:S000000505" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ysfqvahpte 61 typveiaeav fnygdfttml tgiapdqvtr mitgvpwyss rlkpaissal skdgiytian // LOCUS NP_009861 379 aa linear PLN 30-JUN-2025 DEFINITION Cos2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009861 VERSION NP_009861.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178650.1 REFERENCE 1 (residues 1 to 379) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 379) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 379) AUTHORS Feldmann,H., Aigle,M., Aljinovic,G., Andre,B., Baclet,M.C., Barthe,C., Baur,A., Becam,A.M., Biteau,N., Boles,E. et al. TITLE Complete DNA sequence of yeast chromosome II JOURNAL EMBO J. 13 (24), 5795-5809 (1994) PUBMED 7813418 REFERENCE 4 (residues 1 to 379) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07417. Method: conceptual translation. FEATURES Location/Qualifiers source 1..379 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="II" Protein 1..379 /product="Cos2p" /calculated_mol_wt="45034" Region 73..167 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 262..351 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..379 /gene="COS2" /locus_tag="YBR302C" /coded_by="NM_001178650.1:1..1140" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:25942624]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /db_xref="GeneID:852605" /db_xref="SGD:S000000506" ORIGIN 1 mkenelknek svdvlsfkql esqkivlpqd lfrssftwfc yeiykslafr iwmllwlpls 61 vwwklsnnci yplivsllvl flgpifvlvi cglsrkrsls kqliqfckei tentpssdph 121 dwevvaanln sylyennvwn tkyfffnamv cqeafrttll epfslkkdka akvksfkdsv 181 pyieealgvy ftevekqwkl fntekswspv gledaklpke ayrfkltwfl krisnifmli 241 pflnflcciy vsrgmclllr tlylgwilfm lvqgfqnirv limsmehkmq flstiineqe 301 sgangwdeia rkmnrylfek kawkneefff dgidcewffn hffyrvlsak ksmwplplnv 361 elwpyikeaq lsrsevllv // LOCUS NP_009863 615 aa linear PLN 30-JUN-2025 DEFINITION glutathione exchanger [Saccharomyces cerevisiae S288C]. ACCESSION NP_009863 VERSION NP_009863.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178711.1 REFERENCE 1 (residues 1 to 615) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 615) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 615) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 615) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07418. On Sep 29, 2000 this sequence version replaced NP_009863.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..615 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..615 /product="glutathione exchanger" /calculated_mol_wt="68790" Region 59..571 /region_name="MFS_ARN_like" /note="Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; cd17322" /db_xref="CDD:340880" Site order(73..74,77..78,81,112,162..163,165..167,170,186, 189..190,193,352,355..356,359..361,364,392,396,450..451, 455,459,475,478..479,482..483,486) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340880" CDS 1..615 /gene="GEX1" /locus_tag="YCL073C" /coded_by="NM_001178711.1:1..1848" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:21490148]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21490148]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0034634 glutathione transmembrane transporter activity [PMID:21490148]" /experiment="EXISTENCE:mutant phenotype:GO:0034775 glutathione transmembrane transport [PMID:21490148]" /note="Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway; GEX1 has a paralog, GEX2, that arose from a segmental duplication" /db_xref="GeneID:850289" /db_xref="SGD:S000000575" ORIGIN 1 msssvvgass nkksgirqsc eiiererhsn ddtysmtstf fklkeneims aqfdslkyki 61 llistafvcg fgisldytlr stytgyatns ysehsllstv qvinavvsvg sqvvysrlsd 121 hfgrlrlflv atifyimgti iqsqatrltm yaagsvfync gyvgtnlllt lilsdfsslk 181 wrmfyqyasy wpyiiipwis gniitaanpq knwswniamw afiyplsalp iiflilymky 241 kssktaewrs lkeqarkert gglfenlvfl fwkldivgil litvslgcil vpltlanets 301 qkwhnskiia tlvsggclff iflyweakfa kspllpfkll sdrgiwaplg vtffnfftff 361 iscdylypvl lvsmkessts aarivnlpdf vaataspfys llvaktrklk lsviggcaaw 421 mvcmglfyky rggsgshegv iaasvimgls gllcsnsviv ilqamtthsr mavitgiqyt 481 fsklgaaiga svsgaiwtqt mpnqlyknlg ndtlaeiaya spytfisdyp wgsperdavv 541 esyryvqrii mtvglactvp ffaftmfmrd pelidkathe eftedglvvl pdeenifsqi 601 kalfrhnrsn kklgc // LOCUS NP_009864 458 aa linear PLN 30-JUN-2025 DEFINITION basic amino acid transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_009864 VERSION NP_009864.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178710.1 REFERENCE 1 (residues 1 to 458) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 458) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 458) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 458) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07419. Method: conceptual translation. FEATURES Location/Qualifiers source 1..458 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..458 /product="basic amino acid transporter" /calculated_mol_wt="50094" Region <1..369 /region_name="MFS" /note="Major Facilitator Superfamily; cl28910" /db_xref="CDD:475125" Region <1..186 /region_name="ProP" /note="MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]; COG0477" /db_xref="CDD:440245" Site order(15..16,18..20,23,43,46..47,50,219,222..223,226..228, 231,259,263,316..317,321,325,347,350..351,354..355,358) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:349949" CDS 1..458 /gene="VBA3" /locus_tag="YCL069W" /coded_by="NM_001178710.1:1..1377" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:15572352]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:15572352]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:15572352]" /experiment="EXISTENCE:mutant phenotype:GO:0015174 basic amino acid transmembrane transporter activity [PMID:15572352]" /experiment="EXISTENCE:mutant phenotype:GO:0015802 basic amino acid transport [PMID:15572352]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:15572352]" /note="Permease of basic amino acids in the vacuolar membrane; VBA3 has a paralog, VBA5, that arose from a segmental duplication" /db_xref="GeneID:850290" /db_xref="SGD:S000000574" ORIGIN 1 mnmlivgrvv asvggsglqt lcfvigctmv gersrplvis ilscafavaa ivgpiiggaf 61 tthvtwrwcf yinlpiggla iimflltyka enkgilqqik daigtissft fskfrhqvnf 121 krlmngiifk fdffgfalcs aglvlfllgl tfggnkyswn sgqviaylvl gvllfifslv 181 ydfflfdkfn pepdnisyrp lllrrlvakp aiiiinmvtf llctgyngqm iysvqffqli 241 fassawkagl hlipivitnv iaaiasgvit kklglvkpll ifggvlgvig aglmtlmtnt 301 stkstqigvl llpgfslgfa lqaslmsaql qitkdrpeaa mdfievtafn tfmkslgttl 361 ggvlsttvfs asfhnkvsra hlepyegktv ddmilyrlqn ydgshstign ilsdsiknvf 421 wmdlgfyalg flfcsfssnk kliipkkdet pednledk // LOCUS NP_009865 260 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCL068C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009865 VERSION NP_009865.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178709.1 REFERENCE 1 (residues 1 to 260) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 260) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 260) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 260) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07420. On Sep 29, 2000 this sequence version replaced NP_009865.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..260 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..260 /product="uncharacterized protein" /calculated_mol_wt="30091" Region 196..>257 /region_name="REM" /note="Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cl02520" /db_xref="CDD:470601" CDS 1..260 /locus_tag="YCL068C" /coded_by="NM_001178709.1:1..783" /note="hypothetical protein" /db_xref="GeneID:850291" /db_xref="SGD:S000000573" ORIGIN 1 mfvlidnvla ylleqddlfv tarfaiqgqi vsrrvnkihi snitdvllqq fishtlpynd 61 nivpkkilds mrtavrqlle atacvsrecp lvkrsqdikr arkrllsdwy rlgadanmda 121 vllvvnsawr flavwrpfvn siqhatqely qniahyllhg nvniqrvtal lqlvmgqddl 181 lfsmddvlqe vfriqlylnk mlphnshkwq kpspfdsanl llnfrdwttd nallqellls 241 yptinknkhk nhsvprliqv // LOCUS NP_009866 210 aa linear PLN 30-JUN-2025 DEFINITION homeodomain mating type protein alpha2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009866 VERSION NP_009866.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178708.1 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 210) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07421. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..210 /product="homeodomain mating type protein alpha2" /calculated_mol_wt="24151" Site order(132..134,136,156,162,175,177..178,181..182,184..186, 188) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" Site order(132,135,178,181..182,185) /site_type="other" /note="specific DNA base contacts [nucleotide binding]" /db_xref="CDD:238039" Region 135..188 /region_name="HOX" /note="Homeodomain; smart00389" /db_xref="CDD:197696" CDS 1..210 /gene="HMLALPHA2" /locus_tag="YCL067C" /gene_synonym="ALPHA2" /coded_by="NM_001178708.1:1..633" /note="Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression" /db_xref="GeneID:850292" /db_xref="SGD:S000000572" ORIGIN 1 mnkipikdll npqitdefks sildinkklf siccnlpklp esvtteeeve lrdilgflsr 61 anknrkisde ekkllqttsq ltttitvllk emrsiendrs nyqltqknks adglvfnvvt 121 qdminkstkp yrghrftken vrileswfak nienpyldtk glenlmknts lsriqiknwv 181 snrrrkekti tiapeladll sgeplakkke // LOCUS NP_009867 175 aa linear PLN 30-JUN-2025 DEFINITION transcriptional co-activator mating type protein alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_009867 VERSION NP_009867.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178707.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 175) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07519. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..175 /product="transcriptional co-activator mating type protein alpha" /calculated_mol_wt="20282" Region 84..>143 /region_name="MATalpha_HMGbox" /note="Mating-type protein MAT alpha 1 HMG-box; pfam04769" /db_xref="CDD:398438" CDS 1..175 /gene="HMLALPHA1" /locus_tag="YCL066W" /gene_synonym="ALPHA1" /coded_by="NM_001178707.1:1..528" /note="Silenced copy of ALPHA1 at HML; ALPHA1 encodes a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression" /db_xref="GeneID:850293" /db_xref="SGD:S000000571" ORIGIN 1 mftskpafki knkasksyrn tavskklkek rlaehvrpsc fniirplkkd iqipvpssrf 61 lnkiqihria sgsqntqfrq fnktsikssk kylnsfmafr ayysqfgsgv kqnvlsslla 121 eewhadkmqh giwdyfaqqy nfinpgfgfv ewltnnyaev rgdgywedvf vhlal // LOCUS NP_001018030 360 aa linear PLN 30-JUN-2025 DEFINITION L-serine/L-threonine ammonia-lyase CHA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_001018030 VERSION NP_001018030.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178706.1 REFERENCE 1 (residues 1 to 360) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 360) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 360) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 360) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07423. Method: conceptual translation. FEATURES Location/Qualifiers source 1..360 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..360 /product="L-serine/L-threonine ammonia-lyase CHA1" /EC_number="4.3.1.17" /EC_number="4.3.1.19" /calculated_mol_wt="39170" Region 7..333 /region_name="L-Ser-dehyd" /note="Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L-, D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia; cd06448" /db_xref="CDD:107209" Site order(37,69,181..185) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:107209" Site 37 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:107209" CDS 1..360 /gene="CHA1" /locus_tag="YCL064C" /coded_by="NM_001178706.1:1..1083" /experiment="EXISTENCE:direct assay:GO:0003941 L-serine ammonia-lyase activity [PMID:7042346]" /experiment="EXISTENCE:direct assay:GO:0004794 threonine deaminase activity [PMID:7042346]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:genetic interaction:GO:0006565 L-serine catabolic process [PMID:7042346]" /experiment="EXISTENCE:genetic interaction:GO:0006567 L-threonine catabolic process [PMID:7042346]" /note="Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine" /db_xref="GeneID:850295" /db_xref="SGD:S000000569" ORIGIN 1 msivynktpl lrqffpgkas aqfflkyecl qpsgsfksrg ignlimksai riqkdgkrsp 61 qvfassggna gfaaatacqr lslpctvvvp tatkkrmvdk irntgaqviv sgaywkeadt 121 flktnvmnki dsqviepiyv hpfdnpdiwe ghssmideiv qdlksqhisv nkvkgivcsv 181 gggglyngii qgleryglad ripivgvetn gchvfntslk igqpvqfkki tsiatslgta 241 visnqtfeya rkyntrsvvi edkdvietcl kythqfnmvi epacgaalhl gyntkilena 301 lgsklaaddi viiiacggss ntikdleeal dsmrkkdtpv ievadnfifp eknivnlksa // LOCUS NP_009870 423 aa linear PLN 30-JUN-2025 DEFINITION Vac17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009870 VERSION NP_009870.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178705.1 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 423) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07424. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..423 /product="Vac17p" /calculated_mol_wt="47712" Region 6..422 /region_name="Vac17" /note="Vacuole-related protein 17; pfam17321" /db_xref="CDD:435863" CDS 1..423 /gene="VAC17" /locus_tag="YCL063W" /gene_synonym="YCL062W" /coded_by="NM_001178705.1:1..1272" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12594460]" /experiment="EXISTENCE:genetic interaction:GO:0000011 vacuole inheritance [PMID:12594460]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:12594460]" /experiment="EXISTENCE:physical interaction:GO:0000011 vacuole inheritance [PMID:12594460]" /experiment="EXISTENCE:physical interaction:GO:0043495 protein-membrane adaptor activity [PMID:12642614]" /experiment="EXISTENCE:physical interaction:GO:0071563 Myo2p-Vac17p-Vac8p transport complex [PMID:12594460]" /note="Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p; involved in regulation of asymmetric inheritance of aggregated/misfolded proteins and age reset" /db_xref="GeneID:850296" /db_xref="SGD:S000000568" ORIGIN 1 matqaledit erllirsqea ilqldlwiqr qqrssicqtt dqesldklsq qynqymsqln 61 slyvrsesvr dklskeqqrr litednehqr iedlvrefqd itlrlnelat vpneapndsp 121 qsqstrsslg sfqprplkii erqrlcmvtp skppkksvgf npinevdcps ktnslpcspk 181 kqparnrtlr aakshdtgln kskkpsssdt yesffknrqr lsltffdemd dedfdsdqdt 241 iilpnistpp hvgvtakgae feplrrynsh esilsnkpap skslnlgsfs asffrpsnpt 301 fgtsisnvqv nchptvaatm apsrngpris sskallssfi arsdthtvke nntnlkhasf 361 mdkfnsslst isesfqskrg rknkgmneer isnhnvaqeq knnmdisvsi eelqdalnte 421 llf // LOCUS NP_009871 1096 aa linear PLN 30-JUN-2025 DEFINITION chromatin-modulating protein MRC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009871 VERSION NP_009871.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178704.1 REFERENCE 1 (residues 1 to 1096) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1096) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1096) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1096) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1096) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1096) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1096) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1096) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1096) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07425. On Sep 29, 2000 this sequence version replaced NP_009871.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1096 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1096 /product="chromatin-modulating protein MRC1" /calculated_mol_wt="124196" Region 711..850 /region_name="MRC1" /note="MRC1-like domain; pfam09444" /db_xref="CDD:430616" CDS 1..1096 /gene="MRC1" /locus_tag="YCL061C" /gene_synonym="YCL060C" /coded_by="NM_001178704.1:1..3291" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:19819872]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]" /experiment="EXISTENCE:direct assay:GO:0050821 protein stabilization [PMID:18851837]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:16219777]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:17483413]" /experiment="EXISTENCE:mutant phenotype:GO:0000076 DNA replication checkpoint signaling [PMID:11331602|PMID:11715016|PMID:12944972]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:17323081]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:16137625]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:16219777]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:17483413]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11331602]" /experiment="EXISTENCE:mutant phenotype:GO:0031297 replication fork processing [PMID:18632578]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11331602]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:11715016]" /experiment="EXISTENCE:mutant phenotype:GO:0033262 regulation of nuclear cell cycle DNA replication [PMID:23178807]" /experiment="EXISTENCE:mutant phenotype:GO:0043570 maintenance of DNA repeat elements [PMID:18321795]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:18851837]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:23178807]" /note="S-phase checkpoint protein required for DNA replication; couples DNA helicase and polymerase; stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; defines a novel S-phase checkpoint with Hog1p that coordinates DNA replication and transcription upon osmostress; protects uncapped telomeres; Dia2p-dependent degradation mediates checkpoint recovery; exposure to ethanol affects localization; mammalian claspin homolog" /db_xref="GeneID:850297" /db_xref="SGD:S000000566" ORIGIN 1 mddalhalss ltakkrttty kkvavpilde ndntngngpn didnppeltg ngflfanatl 61 nrvknrlegk kapeqnhnng kdrsenslpt qlisnlydgg eeleksevkd nsyseknvss 121 sftqtqripv siqqdkvfnv pihsvndgkp tqlikedglv netsqalktp lttgrpgatq 181 ridssgatsq tqpiksiepq sqiittssnh snalspkipi ipteligtsp lfqsiqnrgp 241 dtqmdvppqt ahdedktqai gipqathqeq ktqidtvaqt lqdevphtlk ireiqselas 301 edskrekarn veykkpqkpi ptkkffskes fladfddsss nedddiklen ahpkpvqndd 361 elhenksvel nltdetrine krvpllssya nnlkreidss kcitldldsd sdeygdddmd 421 siklskdesv lpisqlskat ilnlkarlsk qnqklsqrpn kskdpkvdhn vllntlrkas 481 rkqildhqke vietkglkle dmakekeive nlleqeilrn krirqkekrr ekleendfql 541 nahdsgsdsg sessgfalsg neiadyessg sendnrresd sekeddeiil kqkkshhvkh 601 iinesdsdte veakpkekad eslpkriain lghygdnige dtdkfqetnv ldtqnieevm 661 aerntienev kddvyvneea deairrqlid keklqlkqke keheakikel kkrgvtnffe 721 meaeesedew hgiggadgeg sddydsdlek middysknnf npheiremla aenkemdikm 781 inkilydikn ggfrnkrakn slelelsddd eddvlqqyrl krrelmrkrr leigddaklv 841 knpkssaffe smvediieyk npfgaeeeyn lditstatdl dtqdnsinvg dntgnneqkp 901 vdqknkkvii sedfvqksls flksnnyedf etdkelsriq hgndeaiedl ytlkqnssik 961 sftnsqtdst tsktvntiid lekrpedede vengdtslvg vfkhpsiiks fasrtdindk 1021 fkegnktvki lksyktvgss kasitymgkt rkliapkrkt egshryhhdh hnkkmkmktk 1081 tksnklfesg qdsfdn // LOCUS NP_009872 316 aa linear PLN 30-JUN-2025 DEFINITION ribosome biosynthesis protein KRR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009872 VERSION NP_009872.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178703.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 316) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07426. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..316 /product="ribosome biosynthesis protein KRR1" /calculated_mol_wt="37028" Region 35..117 /region_name="KH-I_KRR1_rpt1" /note="first type I K homology (KH) RNA-binding domain found in KRR1 small subunit processome component and similar proteins; cd22393" /db_xref="CDD:411821" Site order(40,42..49,73..79,90..92,95) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:411821" Region 121..213 /region_name="KH-I_KRR1_rpt2" /note="second type I K homology (KH) RNA-binding domain found in KRR1 small subunit processome component and similar proteins; cd22394" /db_xref="CDD:411822" Site order(129..130,133..134,169,195) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:411822" Site order(144,152,155,193,195,197..198,200..201,204) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:411822" CDS 1..316 /gene="KRR1" /locus_tag="YCL059C" /coded_by="NM_001178703.1:1..951" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12150911|PMID:11027267]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11027267]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11996121]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:12150911]" /note="Nucleolar protein required for rRNA synthesis and ribosomal assembly; required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit; essential gene" /db_xref="GeneID:850298" /db_xref="SGD:S000000564" ORIGIN 1 mvsthnrdkp wdtddidkwk ieefkeedna sgqpfaeess fmtlfpkyre sylktiwndv 61 traldkhnia cvldlvegsm tvkttrktyd paiilkardl ikllarsvpf pqavkilqdd 121 macdvikign fvtnkerfvk rrqrlvgpng ntlkalellt kcyilvqgnt vsamgpfkgl 181 kevrrvvedc mknihpiyhi kelmikrela krpelanedw srflpmfkkr nvarkkpkki 241 rnvekkvytp fppaqlprkv dleiesgeyf lskrekqmkk lneqkekqme reierqeera 301 kdfiapeeea ykpnqn // LOCUS NP_009873 152 aa linear PLN 30-JUN-2025 DEFINITION Fyv5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009873 VERSION NP_009873.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178702.1 REFERENCE 1 (residues 1 to 152) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 152) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 152) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 152) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA33856. Method: conceptual translation. FEATURES Location/Qualifiers source 1..152 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..152 /product="Fyv5p" /calculated_mol_wt="17008" CDS 1..152 /gene="FYV5" /locus_tag="YCL058C" /gene_synonym="MDF1" /coded_by="NM_001178702.1:1..459" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:20195295]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:10234789]" /note="De novo-originated gene from non-coding sequence; protein can suppress mating and promote vegetative growth; shortens lag phase by physically interacting with Snf1p; binds with Matalpha2p to promoters of haploid-specific genes; functions in mating and fermentation, mediates crosstalk between reproduction and vegetative growth; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis" /db_xref="GeneID:850299" /db_xref="SGD:S000000563" ORIGIN 1 mqyhsalyvy iyvtfttipy kekpdiisic fsmlsfvfdf svricsrtle sfswslisss 61 afkvvsafsl agscvlasrs svgiivslll fnfstcnfvl flsavlidlf fctflptptf 121 lptpfffmlh lpifsllnal ellyliiagl hi // LOCUS NP_001018031 113 aa linear PLN 30-JUN-2025 DEFINITION Adf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001018031 VERSION NP_001018031.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184528.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 113) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07427. On Jan 23, 2006 this sequence version replaced NP_001018031.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..113 /product="Adf1p" /calculated_mol_wt="12608" CDS 1..113 /gene="ADF1" /locus_tag="YCL058W-A" /coded_by="NM_001184528.1:1..342" /experiment="EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:20195295]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20195295]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:20195295]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:20195295]" /note="Transcriptional repressor encoded by the FYV5 antisense strand; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand" /db_xref="GeneID:3289591" /db_xref="SGD:S000028518" ORIGIN 1 mgkcsmkkkg vgknvgvgkk vqkkrsista erkrtklqve klnkssetmi ptllreastq 61 epaklkaett lkaeelikdq ekdskvreqi rteksktnds mlkqiemisg fsl // LOCUS NP_065435 97 aa linear PLN 30-JUN-2025 DEFINITION Mic10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_065435 VERSION NP_065435.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184448.1 REFERENCE 1 (residues 1 to 97) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 97) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 97) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 97) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07428. Method: conceptual translation. FEATURES Location/Qualifiers source 1..97 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..97 /product="Mic10p" /calculated_mol_wt="10277" Region 4..87 /region_name="DUF543" /note="Domain of unknown function (DUF543); pfam04418" /db_xref="CDD:461300" CDS 1..97 /gene="MIC10" /locus_tag="YCL057C-A" /gene_synonym="MCS10; MIO10; MOS1" /coded_by="NM_001184448.1:1..294" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0042407 cristae formation [PMID:35081352]" /experiment="EXISTENCE:direct assay:GO:0044284 mitochondrial crista junction [PMID:35081352|PMID:22009199]" /experiment="EXISTENCE:direct assay:GO:0061024 membrane organization [PMID:25955211]" /experiment="EXISTENCE:direct assay:GO:0061617 MICOS complex [PMID:22009199|PMID:21987634|PMID:21944719]" /experiment="EXISTENCE:direct assay:GO:0140260 mitochondrial proton-transporting ATP synthase complex binding [PMID:35081352]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:21987634|PMID:22009199|PMID:21944719]" /note="Conserved component of the MICOS complex; MICOS (formerly MINOS or MitOS), a mitochondrial inner membrane (MIM) complex extends into the intermembrane space and has a role in the maintenance of crista junctions, MIM architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic12p and Mic27p whose assembly and stability requires cardiolipin; homo-oligomers cause membrane bending; oligomerization state regulated by Mic26p and Mic27p; ortholog of human MINOS1" /db_xref="GeneID:850300" /db_xref="SGD:S000007547" ORIGIN 1 mseqaqtqqp akstpskdsn kngssvstil dtkwdivlsn mlvktamgfg vgvftsvlff 61 krrafpvwlg igfgvgrgya egdaifrssa glrsskv // LOCUS NP_009874 712 aa linear PLN 30-JUN-2025 DEFINITION metalloendopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009874 VERSION NP_009874.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178701.1 REFERENCE 1 (residues 1 to 712) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 712) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 712) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 712) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07429. Method: conceptual translation. FEATURES Location/Qualifiers source 1..712 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..712 /product="metalloendopeptidase" /EC_number="3.4.24.37" /calculated_mol_wt="81803" Region 54..708 /region_name="M3A_TOP" /note="Peptidase M3 thimet oligopeptidase (TOP), also includes neurolysin; cd06455" /db_xref="CDD:341050" Site order(501..502,505,531,633,639..640,642..643,646) /site_type="active" /db_xref="CDD:341050" CDS 1..712 /gene="PRD1" /locus_tag="YCL057W" /coded_by="NM_001178701.1:1..2139" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:8218194]" /experiment="EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:8218194|PMID:8307027]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8307027|PMID:24390141|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:8307027]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8218194]" /experiment="EXISTENCE:direct assay:GO:0006508 proteolysis [PMID:8307027]" /experiment="EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:8307027]" /experiment="EXISTENCE:mutant phenotype:GO:0006508 proteolysis [PMID:8307027]" /note="Zinc metalloendopeptidase; found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850301" /db_xref="SGD:S000000562" ORIGIN 1 mrlllcknwf aspvisplly trslysmant tsfpiapqap pnwsftpsdi sgktneiinn 61 snnfydsmsk vespsvsnfv epfmkfenel gpiinqltfl qhvssdkeir dasvnssmkl 121 delnidlslr hdiflqfarv wqdvqskads veretfkyve ksykdyihsg leldegnrlk 181 ikeikkkisv nsinfsknlg eqkeyitftk eqlegvpdsi ltqfetiksd kdsnetlykv 241 tfkypdifpv mklassaqtr kqafladqnk vpeneailld tlklrdelas llgydtyany 301 nlydkmaeds ttvmnflndl kdkliplgrk elqvlqdmka edvkklnqga dpnyyiwdhr 361 yydnkyllen fnvdlekise yfpleatitg mleiyetlfn lkfietkdsq nksvwhddvk 421 qiavwnmddp kspnfvgwiy fdlhprdgky ghaanfglss sfmiddttrs ypvtalvcnf 481 skstkdkpsl lkhneivtff helghgihdl vgqnkesrfn gpgsvpwdfv eapsqmlefw 541 twnknelinl sshyktgeki peslinslik tkhvngalft lrqlhfglfd mkvhtckdlq 601 nlsicdtwnq lrqdislisn ggtlskgyds fghimsdsys agyygylwae vfatdmyhtk 661 fakdplnakn giqyrdivla rgglydindn lkeflgreps kdaflkelgl qn // LOCUS NP_009875 144 aa linear PLN 30-JUN-2025 DEFINITION Pex34p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009875 VERSION NP_009875.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178700.1 REFERENCE 1 (residues 1 to 144) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 144) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 144) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 144) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07430. Method: conceptual translation. FEATURES Location/Qualifiers source 1..144 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..144 /product="Pex34p" /calculated_mol_wt="16462" CDS 1..144 /gene="PEX34" /locus_tag="YCL056C" /coded_by="NM_001178700.1:1..435" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:21441307]" /experiment="EXISTENCE:direct assay:GO:0160189 peroxisomal-mitochondrial contact site [PMID:29720625]" /experiment="EXISTENCE:genetic interaction:GO:0007031 peroxisome organization [PMID:21441307]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:21441307]" /experiment="EXISTENCE:mutant phenotype:GO:0160190 peroxisome-mitochondrion membrane tether activity [PMID:29720625]" /note="Protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation; mediates contacts between mitochondria and peroxisomes that stimulate transport of citrate, converted from acetyl-CoA, from peroxisomes to mitochondria; peroxisomal integral membrane protein that is enriched at peroxisomal-mitochondrial (PerMit) contact sites" /db_xref="GeneID:850302" /db_xref="SGD:S000000561" ORIGIN 1 mvskkntaei sakdiweniw sgvsslldff avlenlgvvn dklyvsgllr kvwlcyscis 61 vikcvwklik lckvkfkidq rldgegnglv kdklinfkkk ynehirhita allqdlsylm 121 vliypgtrlf krlsniitlc riiv // LOCUS NP_009876 335 aa linear PLN 30-JUN-2025 DEFINITION Kar4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009876 VERSION NP_009876.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178699.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 335) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07431. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..335 /product="Kar4p" /calculated_mol_wt="38541" Region 138..293 /region_name="MT-A70" /note="cl01947" /db_xref="CDD:470404" CDS 1..335 /gene="KAR4" /locus_tag="YCL055W" /coded_by="NM_001178699.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:17101777]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0003700 DNA-binding transcription factor activity [PMID:17101777]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:8754797]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:17101777]" /experiment="EXISTENCE:mutant phenotype:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:37603553]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17101777]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:37603553|PMID:8754797]" /experiment="EXISTENCE:physical interaction:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:37603553]" /note="Transcription factor required for the mating response; subunit of the mRNA m6A methyltransferase (MIS) complex, regulating meiosis at multiple steps, early prior to pre-meiotic S phase and late during the completion of meiosis and sporulation; exists in two forms, a slower-migrating form abundant during vegetative growth and a faster-migrating pheromone-induced form; null mutant exhibits abnormal lipid metabolic phenotype; homologous to human METTL14, a subunit of a m6A methyltransferase complex" /db_xref="GeneID:850303" /db_xref="SGD:S000000560" ORIGIN 1 mafqdptydq nksrhinnsh lqgpnqetie mkskhvsfkp srdfhtndys nnyihgkslp 61 qqhvtnienr vdgypklqkl fqakakqinq fattpfgcki gidsivptln hwiqnenltf 121 dvvmigclte nqfiypiltq lpldrliskp gflfiwansq kineltklln neiwakkfrr 181 seelvfvpid kkspfypgld qddetlmekm qwhcwmcitg tvrrstdghl ihcnvdtdls 241 ietkdttnga vpshlyriae nfstatrrlh iipartgyet pvkvrpgwvi vspdvmldnf 301 spkrykeeia nlgsniplkn eiellrprsp vqkaq // LOCUS NP_001291943 28 aa linear PLN 30-JUN-2025 DEFINITION Rdt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001291943 VERSION NP_001291943.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001305014.1 REFERENCE 1 (residues 1 to 28) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 28) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 28) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 28) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA64696. Method: conceptual translation. FEATURES Location/Qualifiers source 1..28 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..28 /product="Rdt1p" /calculated_mol_wt="3337" CDS 1..28 /gene="RDT1" /locus_tag="YCL054W-A" /coded_by="NM_001305014.1:1..87" /note="Small gene in chromosome III recombination enhancer; activated during mating-type switching; bound by condensin complex, deletion drastically changes chromosome III structure, alters donor preference; promoter functions as locus control region (LCR) that regulates both transcription and long-range chromatin interactions" /db_xref="GeneID:23547378" /db_xref="SGD:S000178054" ORIGIN 1 mirqkifvfi vksrrnsicp airrkedy // LOCUS NP_009877 841 aa linear PLN 30-JUN-2025 DEFINITION 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009877 VERSION NP_009877.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178698.1 REFERENCE 1 (residues 1 to 841) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 841) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 841) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 841) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 841) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 841) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 841) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 841) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 841) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07432. Method: conceptual translation. FEATURES Location/Qualifiers source 1..841 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..841 /product="27S pre-rRNA (guanosine2922-2'-O)-methyltransferase" /EC_number="2.1.1.167" /calculated_mol_wt="96354" Region 1..204 /region_name="RlmE" /note="23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]; COG0293" /db_xref="CDD:440062" Region 236..384 /region_name="DUF3381" /note="Domain of unknown function (DUF3381); pfam11861" /db_xref="CDD:463375" Region 621..835 /region_name="Spb1_C" /note="Spb1 C-terminal domain; pfam07780" /db_xref="CDD:462264" CDS 1..841 /gene="SPB1" /locus_tag="YCL054W" /coded_by="NM_001178698.1:1..2526" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10556316]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10556316|PMID:10648622]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614]" /experiment="EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:15546625]" /experiment="EXISTENCE:genetic interaction:GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity [PMID:14636587]" /experiment="EXISTENCE:genetic interaction:GO:0031167 rRNA methylation [PMID:14636587|PMID:15546625]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10648622|PMID:10556316]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10556316|PMID:10648622]" /experiment="EXISTENCE:mutant phenotype:GO:0016435 rRNA (guanine) methyltransferase activity [PMID:15546625]" /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:15546625]" /note="AdoMet-dependent methyltransferase; involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants" /db_xref="GeneID:850304" /db_xref="SGD:S000000559" ORIGIN 1 mgktqkknsk grldryyyla kekgyrarss fkiiqineky ghflekskvv idlcaapgsw 61 cqvasklcpv nsliigvdiv pmkpmpnvit fqsdittedc rsklrgymkt wkadtvlhdg 121 apnvglgwvq daftqsqltl qalklavenl vvngtfvtki frskdynkli wvfqqlfekv 181 eatkppasrn vsaeifvvck gfkapkrldp rlldpkevfe elpdgqqnme skiynpekkv 241 rkrqgyeegd nllyhetsil dfvrtedpis mlgemnkfti dendhewkil kklkqttdef 301 rsciedlkvl gkkdfkmilr wrkiareilg ievkddakte ievvplteee qiekdlqglq 361 ekqrlnvkre rrrknemkqk elqrmqmnmi tptdigieaa slgkeslfnl ktaektgiln 421 dlakgkkrmi ftddelakdn diyidenimi kdkdsaadad dleselnamy sdyktrrser 481 dakfrakqar ggdneeewtg fnegslekke eegkdyiedn ddegvegdsd ddeaitnlis 541 klkgqegdhk lsskarmifn dpifnnvepd lpvntvndgi mssesvgdis klnkkrkhee 601 mhqkqdeads sdesssddsd feivandnas eefdsdydse eeknqtkkek hsrdidiatv 661 eamtlahqla lgqknkhdlv degfnrytfr dtenlpdwfl edekehskin kpitkeaama 721 ikekikamna rpikkvaeak arkrmravar lekikkkagl inddsdktek dkaeeisrlm 781 rkvtkkpktk pkvtlvvasg rnkglagrpk gvkgkykmvd gvmkneqral rriakkhhkk 841 k // LOCUS NP_009878 416 aa linear PLN 30-JUN-2025 DEFINITION Pbn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009878 VERSION NP_009878.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178697.1 REFERENCE 1 (residues 1 to 416) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 416) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 416) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 416) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07433. Method: conceptual translation. FEATURES Location/Qualifiers source 1..416 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..416 /product="Pbn1p" /calculated_mol_wt="47792" Region 224..406 /region_name="PIG-X" /note="PIG-X / PBN1; smart00780" /db_xref="CDD:197872" CDS 1..416 /gene="PBN1" /locus_tag="YCL052C" /coded_by="NM_001178697.1:1..1251" /experiment="EXISTENCE:direct assay:GO:0000030 mannosyltransferase activity [PMID:15635094]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:9649520]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:15635094]" /experiment="EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:9649520]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:16418276]" /experiment="EXISTENCE:physical interaction:GO:1990529 glycosylphosphatidylinositol-mannosyltransferase I complex [PMID:15635094]" /note="Component of glycosylphosphatidylinositol-mannosyltransferase I; essential component; required for the autocatalytic post-translational processing of the protease B precursor Prb1p; localizes to ER in lumenal orientation; homolog of mammalian PIG-X" /db_xref="GeneID:850305" /db_xref="SGD:S000000557" ORIGIN 1 mvtrhrvtvl ynapedignh mrqndthltv rggsgvvlqq rwllertgsl dksftritwr 61 pradlarsls vienelsagf svysnssdvp erfitnpvyn sfhsekfdie qylppevdln 121 lswnpedfty disveptqiq iveyrllkqg eeftiarvkd eklevgvffv dasdesdvdi 181 ggircnwrmd dgkmercqkt sllykqghia ynhsttttsl ylnepiglhp kimidltdfe 241 erpkcmylmh lqlplelfid kfqssplllf geddlelpey slrdkawgse sifelkagtm 301 nevtlhtryi epsnnkgdkl evsfdpevil acdtgdnkvs rnpfykkglg yeslftddtt 361 frhlnsttll vpiprpdtkd yskikngtll cllisiiyif skvfgnnkkk rsvkre // LOCUS NP_009879 583 aa linear PLN 30-JUN-2025 DEFINITION Lre1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009879 VERSION NP_009879.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178696.1 REFERENCE 1 (residues 1 to 583) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 583) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 583) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 583) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07434. On Sep 29, 2000 this sequence version replaced NP_009879.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..583 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..583 /product="Lre1p" /calculated_mol_wt="64661" CDS 1..583 /gene="LRE1" /locus_tag="YCL051W" /coded_by="NM_001178696.1:1..1752" /experiment="EXISTENCE:direct assay:GO:0004860 protein kinase inhibitor activity [PMID:23954433]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:23954433]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:11532139]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:9090049]" /note="Protein involved in control of cell wall structure and stress response; direct inhibitor of the nuclear Dbf2 related (NDR) kinase Cbk1p-Mob2p; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway; LRE1 has a paralog, HLR1, that arose from the whole genome duplication" /db_xref="GeneID:850306" /db_xref="SGD:S000000556" ORIGIN 1 mpnthtqhvq isepnpvntl stpskrghrh rrslaisgdf dflkqpaaiv nlpppqaaen 61 cpstaptavs stlspirynr fpcktnedag tldlpeprfy plspknnlqt psprffisee 121 psfsspvkgv pdaiinldda lktrprsfks hrrsesappd levmvdkgnc aagsnsmike 181 eedsliepes kneyyeqklp tallsplrps lcvseqaidv ddsalngspt hhnhgmqnan 241 arnsntfnsl kikgqkqryy hytkqlpltv gcdsqspkeq rsaasmtinq amtpsslayt 301 psklastpat pvsfydsnad inlesdnfpl kdnpryakdg ypkkcgnsql nrvldsdkrq 361 dfsgesrrrr sgspishmqh rnlidnmkgr rnsntinsif nyksqhyemp yddmmkneni 421 naqsmpfsvn gvnnensigg vitraddapl qhsvvksctp dgkeemnrlk sndsneysks 481 egqirtnsql skdilmgepg dmvdlssfvn aqrkasnetg dlvfslsqdd dalktfhasn 541 saatsneswc isddalgkqa qdsevrrkrk sklglfrhif srk // LOCUS NP_009880 321 aa linear PLN 30-JUN-2025 DEFINITION bifunctional AP-4-A phosphorylase/ADP sulfurylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009880 VERSION NP_009880.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178695.1 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 321) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07435. On Sep 29, 2000 this sequence version replaced NP_009880.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..321 /product="bifunctional AP-4-A phosphorylase/ADP sulfurylase" /EC_number="2.7.7.5" /EC_number="2.7.7.53" /calculated_mol_wt="36362" Region 16..287 /region_name="APA2" /note="ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; COG4360" /db_xref="CDD:443494" Region 194..309 /region_name="ATP_transf" /note="ATP adenylyltransferase C-terminal domain; pfam09830" /db_xref="CDD:430861" CDS 1..321 /gene="APA1" /locus_tag="YCL050C" /gene_synonym="DTP1" /coded_by="NM_001178695.1:1..966" /experiment="EXISTENCE:direct assay:GO:0004780 sulfate adenylyltransferase (ADP) activity [PMID:2556364]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity [PMID:2174863|PMID:2556364]" /experiment="EXISTENCE:direct assay:GO:0009164 nucleoside catabolic process [PMID:2174863]" /experiment="EXISTENCE:direct assay:GO:0009165 nucleotide biosynthetic process [PMID:2172926]" /experiment="EXISTENCE:genetic interaction:GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity [PMID:2174863]" /experiment="EXISTENCE:genetic interaction:GO:0009164 nucleoside catabolic process [PMID:2174863]" /experiment="EXISTENCE:mutant phenotype:GO:0004780 sulfate adenylyltransferase (ADP) activity [PMID:2556364]" /experiment="EXISTENCE:mutant phenotype:GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity [PMID:2174863|PMID:2556364]" /experiment="EXISTENCE:mutant phenotype:GO:0009164 nucleoside catabolic process [PMID:2174863]" /note="AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication" /db_xref="GeneID:850307" /db_xref="SGD:S000000555" ORIGIN 1 msipadiasl isdkyksafd ngnlkfiqte ttktkdpkts mpylishmps liekpergqt 61 pegedplgkp eeeltvipef ggadnkaykl llnkfpvipe htllvtneyq hqtdaltptd 121 lltaykllca ldneesdkrh mvfynsgpas gssldhkhlq ilqmpekfvt fqdrlcngke 181 hflptfntep lqdakvsfah fvlpmpesee tvdedllamc yisilqralt ffqdwlnenp 241 elkksynlml tkewicvvpr skafsdemki gfnstgycgm iltkndevfs kitekpelin 301 dillecgfpn tsgqkpneyn y // LOCUS NP_009881 312 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCL049C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009881 VERSION NP_009881.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178694.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 312) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07436. On Sep 29, 2000 this sequence version replaced NP_009881.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..312 /product="uncharacterized protein" /calculated_mol_wt="35521" CDS 1..312 /locus_tag="YCL049C" /coded_by="NM_001178694.1:1..939" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11935221]" /note="hypothetical protein; localizes to membrane fraction; YCL049C is not an essential gene" /db_xref="GeneID:850308" /db_xref="SGD:S000000554" ORIGIN 1 mfskylvtas slfvaltsaa stvdldalll lpgveshdgv dtvfstkdfy qvsfvksiap 61 aivnssvifh dvsrgvamgn vksrasifnp eetyydweqy qvvnngdwrt ewapasdciw 121 reekdnsdet pdrfpisvpy nwtsqysivd ydtdanednl dfrfikslld kknwlkkinq 181 tvsqssimva pmirpynvvq lwyskdmvwa nvqrqycsgv ypggtqcsaw sryyhvdapt 241 cdepvasymt kmlenevqcp nernattlep lrlnkqgdsd fsltfeeeee eetgskslws 301 tlkkifskrs is // LOCUS NP_001032573 79 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCL048W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032573 VERSION NP_001032573.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184678.1 REFERENCE 1 (residues 1 to 79) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 79) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 79) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 79) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07437. Method: conceptual translation. FEATURES Location/Qualifiers source 1..79 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..79 /product="uncharacterized protein" /calculated_mol_wt="7667" CDS 1..79 /locus_tag="YCL048W-A" /coded_by="NM_001184678.1:1..240" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCL048W-A has a paralog, YDR524C-B, that arose from the whole genome duplication" /db_xref="GeneID:3799968" /db_xref="SGD:S000087203" ORIGIN 1 mqiknivavl atvtainaqv giepnattpn atqpnatqpn ttlptasvtt tvsigeavvn 61 tmaagafgaa iaagvaflf // LOCUS NP_009882 463 aa linear PLN 30-JUN-2025 DEFINITION Sps22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009882 VERSION NP_009882.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178693.1 REFERENCE 1 (residues 1 to 463) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 463) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 463) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 463) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07438. Method: conceptual translation. FEATURES Location/Qualifiers source 1..463 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..463 /product="Sps22p" /calculated_mol_wt="51877" CDS 1..463 /gene="SPS22" /locus_tag="YCL048W" /coded_by="NM_001178693.1:1..1392" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]" /note="hypothetical protein; SPS22 has a paralog, SPS2, that arose from the whole genome duplication; redundant with Sps2p for the organization of the beta-glucan layer of the spore wall" /db_xref="GeneID:850309" /db_xref="SGD:S000000553" ORIGIN 1 mnritrkscl faiifaslfv thalgaaidp prrphnvkpf hngnlelqrr anepffeidv 61 kslntnspis elckkdlhvi esshdlfhlq nqcefilgsl kvtnydsnil dlnslraigg 121 dliiqdspel iriqagnlnk ieglfqlqgl tslvsveipt lkfcqslewk vvpilnyvsm 181 dsqnieiikd ivisdtslan ienfnkvqei dtfninnnrf letihsnvkt irgqfsvhan 241 akelelemph lrevenitir dtslvylpql tkvksslefi enyfyelnln nlqkiggtlg 301 iinnvnlikv nlenltdiqg glmiadnesl editflpnlk qiggaiffeg sfkdimfdsl 361 klvkgsafik sssnvldcnk wtnpsngrsi irggkftcis gkkentlnvk qdgtiiekgy 421 kdltqegeds kkrviskyan sanpsmqldp llfgtclvam llf // LOCUS NP_009883 258 aa linear PLN 30-JUN-2025 DEFINITION nicotinamide-nucleotide adenylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009883 VERSION NP_009883.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178692.1 REFERENCE 1 (residues 1 to 258) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 258) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 258) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 258) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07439. Method: conceptual translation. FEATURES Location/Qualifiers source 1..258 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..258 /product="nicotinamide-nucleotide adenylyltransferase" /EC_number="2.7.7.1" /calculated_mol_wt="29542" Region 31..254 /region_name="NMNAT" /note="Nicotinamide/nicotinate mononucleotide adenylyltransferase; cd02165" /db_xref="CDD:185680" Site order(32..36,40,42..43,46,71,112..114,135,137..138, 140..141,150..151,173..174,221) /site_type="active" /db_xref="CDD:185680" Site 40..43 /site_type="other" /note="(T/H)XGH motif" /db_xref="CDD:185680" CDS 1..258 /gene="POF1" /locus_tag="YCL047C" /coded_by="NM_001178692.1:1..777" /experiment="EXISTENCE:direct assay:GO:0000309 nicotinamide-nucleotide adenylyltransferase activity [PMID:24759102]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24759102]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24759102]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:22204397]" /experiment="EXISTENCE:genetic interaction:GO:0000309 nicotinamide-nucleotide adenylyltransferase activity [PMID:24759102]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:21460040]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:21460040]" /experiment="EXISTENCE:genetic interaction:GO:0034355 NAD+ biosynthetic process via the salvage pathway [PMID:24759102]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:22204397]" /experiment="EXISTENCE:physical interaction:GO:0036503 ERAD pathway [PMID:22204397]" /note="Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT); catalyzes the conversion of nicotinamide mononucleotide (NMN) to nicotinamide adenine dinucleotide (NAD+); role in the nicotinamide riboside (NR) salvage pathway of NAD+ biosynthesis; involved in NR and NAD+ homeostasis; ATPase involved in protein quality control and filamentation pathways; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion" /db_xref="GeneID:850310" /db_xref="SGD:S000000552" ORIGIN 1 mkktfeqfrk snllfqvlkg pqhlecqklf vldssfnpph lahfqllsqt iknfklkdtr 61 shvllllavn nadklpkpas fptrlemmcl fadylqeklp qsvvsvgltv fskfidkdki 121 lheqfvkgcs adigylvgfd tiarifdeky yhplkisdvm esfmsgsqly clargdchls 181 aesqlryasd ilegkfepvi prewgarihv mqndypalrn vssseirnkl kngqveslkd 241 elplciydyl innktifd // LOCUS NP_009884 760 aa linear PLN 30-JUN-2025 DEFINITION Emc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009884 VERSION NP_009884.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178690.1 REFERENCE 1 (residues 1 to 760) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 760) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 760) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 760) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07440. Method: conceptual translation. FEATURES Location/Qualifiers source 1..760 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..760 /product="Emc1p" /calculated_mol_wt="87051" Region 538..757 /region_name="EMC1_C" /note="ER membrane protein complex subunit 1, C-terminal; pfam07774" /db_xref="CDD:462261" CDS 1..760 /gene="EMC1" /locus_tag="YCL045C" /coded_by="NM_001178690.1:1..2283" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0072546 EMC complex [PMID:19325107]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]" /note="Member of conserved endoplasmic reticulum membrane complex; involved in efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p; homologous to worm H17B01.4/EMC-1, fly CG2943, and human KIAA0090" /db_xref="GeneID:850312" /db_xref="SGD:S000000550" ORIGIN 1 mkitctdlvy vfillflnts cvqavfsdda fitdwqlanl gpwekvipds rdrnrvlils 61 nptetsclvs sfnvssgqil frnvlpftid eiqldsndhn amvcvnsssn hwqkydlhdw 121 flleegvdna psttilpqss ylndqvsikn nelhildeqs klaewklelp qgfnkveyfh 181 redplalvln vndtqymgfs angtelipvw qrdewltnvv dyavldvfds rdvelnkdmk 241 aeldsnslwn aywlrlttnw nrlinllken qfspgrvftk llaldakdtt vsdlkfgfak 301 ilivlthdgf iggldmvnkg qliwkldlei dqgvkmfwtd knhdelvvfs hdghyltiev 361 tkdqpiiksr splserktvd svirlnehdh qylikfedkd hllfklnpgk ntdvpivann 421 hssshifvte hdtngiygyi iendtvkqtw kkavnskekm vayskrettn lntlgitlgd 481 ksvlykylyp nlaayliane ehhtitfnli dtitgeilit qehkdspdfr fpmdivfgey 541 wvvysyfsse pvpeqklvvv elyesltpde rlsnssdnfs ydpltghink pqfqtkqfif 601 peiiktmsis kttddittka ivmelengqi tyipklllna rgkpaeemak dkkkefmatp 661 ytpvipindn fiithfrnll pgsdsqlisi ptnlestsii cdlgldvfct ritpsgqfdl 721 msptfekgkl litifvllvi tyfirpsvsn kklksqwlik // LOCUS NP_009886 417 aa linear PLN 30-JUN-2025 DEFINITION Mgr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009886 VERSION NP_009886.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178689.1 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 417) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07441. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..417 /product="Mgr1p" /calculated_mol_wt="47025" Region 1..388 /region_name="Mgr1" /note="Mgr1-like, i-AAA protease complex subunit; pfam08602" /db_xref="CDD:369991" CDS 1..417 /gene="MGR1" /locus_tag="YCL044C" /coded_by="NM_001178689.1:1..1254" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14562095|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0031942 i-AAA complex [PMID:16267274|PMID:18843051]" /experiment="EXISTENCE:direct assay:GO:0051787 misfolded protein binding [PMID:18843051]" /experiment="EXISTENCE:mutant phenotype:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:18843051]" /note="Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA" /db_xref="GeneID:850313" /db_xref="SGD:S000000549" ORIGIN 1 mavftppsgn snstdhthtq ddhdkddndi kkfyirpslg lklwgplvpa pdnlpglytl 61 itiqsavgff alwrlrrlyk lppprriatg thsdlsfgel psemivngkt kikkdiadfp 121 tlnrfstthg divlapppii prqsrfvsvr kllwglfgsl llsqsllelt rlnflkydpw 181 cdemksvrdk kffnnivkyy hegidptkik vkdamngtpl stnipevkqs valaraqvea 241 qnpiikwfgp leykpmsfne ylnrmefhld mfeffqnkrn irensielin sishnpqsss 301 tgleglsesk klhlqnvekr lhflassgds isapvkkrss ttlsrgvilp hdtkgpqdid 361 ldtirslydp wmtlaletsl sikfipttmp shtktptstd qplpgptpka ltnekth // LOCUS NP_009887 522 aa linear PLN 30-JUN-2025 DEFINITION protein disulfide isomerase PDI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009887 VERSION NP_009887.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178688.1 REFERENCE 1 (residues 1 to 522) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 522) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 522) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 522) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07442. Method: conceptual translation. FEATURES Location/Qualifiers source 1..522 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..522 /product="protein disulfide isomerase PDI1" /EC_number="5.3.4.1" /calculated_mol_wt="58096" Region 32..492 /region_name="ER_PDI_fam" /note="protein disulfide isomerase, eukaryotic; TIGR01130" /db_xref="CDD:273457" CDS 1..522 /gene="PDI1" /locus_tag="YCL043C" /gene_synonym="MFP1; TRG1" /coded_by="NM_001178688.1:1..1569" /experiment="EXISTENCE:direct assay:GO:0003756 protein disulfide isomerase activity [PMID:16413482|PMID:16002399]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:1761554]" /experiment="EXISTENCE:direct assay:GO:0015035 protein-disulfide reductase activity [PMID:16002399]" /experiment="EXISTENCE:direct assay:GO:0036508 protein alpha-1,2-demannosylation [PMID:21700223]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16002399]" /experiment="EXISTENCE:direct assay:GO:1904382 mannose trimming involved in glycoprotein ERAD pathway [PMID:27053108|PMID:21700223]" /experiment="EXISTENCE:genetic interaction:GO:1904382 mannose trimming involved in glycoprotein ERAD pathway [PMID:21700223]" /experiment="EXISTENCE:mutant phenotype:GO:0003756 protein disulfide isomerase activity [PMID:11157982]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:11157982]" /experiment="EXISTENCE:mutant phenotype:GO:1904382 mannose trimming involved in glycoprotein ERAD pathway [PMID:21700223]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:16002399]" /note="Protein disulfide isomerase; multifunctional oxidoreductase of the ER lumen, essential for disulfide bond formation in secretory and cell-surface proteins, and processing non-native disulfide bonds; complexes with exomannosidase, Mnl1p, recognizing misfolded glycoproteins, and reducing disulfide bonds of demannosylated substrates to generate an unfolded polypeptide that can be retrotranslocated across the ER membrane, as part of ERAD; maintains Mnl1p solubility in the ER lumen; Ero1p activator" /db_xref="GeneID:850314" /db_xref="SGD:S000000548" ORIGIN 1 mkfsagavls wsslllassv faqqeavape dsavvklatd sfneyiqshd lvlaeffapw 61 cghcknmape yvkaaetlve knitlaqidc tenqdlcmeh nipgfpslki fknsdvnnsi 121 dyegprtaea ivqfmikqsq pavavvadlp aylanetfvt pvivqsgkid adfnatfysm 181 ankhfndydf vsaenadddf klsiylpsam depvvyngkk adiadadvfe kwlqvealpy 241 fgeidgsvfa qyvesglplg ylfyndeeel eeykplftel akknrglmnf vsidarkfgr 301 hagnlnmkeq fplfaihdmt edlkyglpql seeafdelsd kivleskaie slvkdflkgd 361 aspivksqei fenqdssvfq lvgknhdeiv ndpkkdvlvl yyapwcghck rlaptyqela 421 dtyanatsdv liakldhten dvrgvviegy ptivlypggk ksesvvyqgs rsldslfdfi 481 kenghfdvdg kalyeeaqek aaeeadadae ladeedaihd el // LOCUS NP_009889 119 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCL042W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009889 VERSION NP_009889.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178687.1 REFERENCE 1 (residues 1 to 119) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 119) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 119) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 119) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07443. On Sep 29, 2000 this sequence version replaced NP_009889.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..119 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..119 /product="uncharacterized protein" /calculated_mol_wt="13229" CDS 1..119 /locus_tag="YCL042W" /coded_by="NM_001178687.1:1..360" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /note="hypothetical protein; epitope-tagged protein localizes to the cytoplasm" /db_xref="GeneID:850315" /db_xref="SGD:S000000547" ORIGIN 1 mekkkildaa lapriisgvp tdgqplsggp lswawchttl krwalmktrp ykyplstepp 61 tppsvpnsas vnhntttntt lsytrchstt ytkplrerss rpwtrsatis rlpprswtn // LOCUS NP_009890 500 aa linear PLN 30-JUN-2025 DEFINITION glucokinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009890 VERSION NP_009890.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178685.1 REFERENCE 1 (residues 1 to 500) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 500) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 500) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 500) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07444. Method: conceptual translation. FEATURES Location/Qualifiers source 1..500 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..500 /product="glucokinase" /EC_number="2.7.1.2" /calculated_mol_wt="55247" Region 29..497 /region_name="ASKHA_NBD_GLK1-2_fungi" /note="nucleotide-binding domain (NBD) of hexokinase isozymes glucokinase-1 (GLK-1) and glucokinase-2 (GLK-2) from fungal hexokinase (HK) domain family; cd24088" /db_xref="CDD:466938" CDS 1..500 /gene="GLK1" /locus_tag="YCL040W" /gene_synonym="HOR3" /coded_by="NM_001178685.1:1..1503" /experiment="EXISTENCE:direct assay:GO:0004340 glucokinase activity [PMID:8501032]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0006013 mannose metabolic process [PMID:237183]" /experiment="EXISTENCE:direct assay:GO:0006096 glycolytic process [PMID:8501032]" /experiment="EXISTENCE:genetic interaction:GO:0046323 D-glucose import [PMID:6300872]" /experiment="EXISTENCE:mutant phenotype:GO:0004340 glucokinase activity [PMID:6341351]" /experiment="EXISTENCE:mutant phenotype:GO:0006006 glucose metabolic process [PMID:6300872]" /note="Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication" /db_xref="GeneID:850317" /db_xref="SGD:S000000545" ORIGIN 1 msfddlhkat eraviqavdq icddfevtpe kldeltayfi eqmekglapp keghtlasdk 61 glpmipafvt gspngtergv llaadlggtn fricsvnlhg dhtfsmeqmk skipddlldd 121 envtsddlfg flarrtlafm kkyhpdelak gkdakpmklg ftfsypvdqt slnsgtlirw 181 tkgfriadtv gkdvvqlyqe qlsaqgmpmi kvvaltndtv gtylshcyts dntdsmtsge 241 isepvigcif gtgtngcyme einkitklpq elrdklikeg kthmiinvew gsfdnelkhl 301 pttkydvvid qklstnpgfh lfekrvsgmf lgevlrnilv dlhsqglllq qyrskeqlpr 361 hlttpfqlss evlshieidd stglretels llqslrlptt ptervqiqkl vraisrrsay 421 laavplaail iktnalnkry hgeveigcdg svveyypgfr smlrhalals plgaegerkv 481 hlkiakdgsg vgaalcalva // LOCUS NP_009891 745 aa linear PLN 30-JUN-2025 DEFINITION glucose-induced degradation complex subunit GID7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009891 VERSION NP_009891.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178684.1 REFERENCE 1 (residues 1 to 745) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 745) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 745) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 745) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 745) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 745) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 745) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 745) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 745) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07445. Method: conceptual translation. FEATURES Location/Qualifiers source 1..745 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..745 /product="glucose-induced degradation complex subunit GID7" /calculated_mol_wt="84386" Region 318..741 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(323,341,345,355..356,369..370,388,394,423..424, 437..438,475,480,486..487,500,558,563,569..570,582..583, 632,636,642..643,655..656,675,680,686..687,699..700,730, 734,740..741) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 327..369 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 375..424 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 459..498 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 537..610 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 617..654 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 662..708 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 715..740 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..745 /gene="GID7" /locus_tag="YCL039W" /gene_synonym="MOH2" /coded_by="NM_001178684.1:1..2238" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0034657 GID complex [PMID:18508925]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]" /note="Subunit of GID Complex that binds directly to central component Vid30p; GID complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; Gid7p contains six WD40 repeats; localizes to peroxisomes in oleate-growing cells; computational analysis suggests that Gid7p and Moh1p have similar functions" /db_xref="GeneID:850318" /db_xref="SGD:S000000544" ORIGIN 1 mshtnkiayv lnndteetas pssvgcfdkk qltkllihtl kelgydsaan qlllesggyq 61 nesnhiqtff kliktgqfhl inwqivcslp lahssplrse wlqrlliptp tpattslfdh 121 mllqlqylqq lmssvnsstc sdaeiatlrn yveimilvnr qifleffhpv tnsashkgph 181 talpvlylrk ilknfieiwd sllvsndqfl neenifnpet tlrelstylt npkltaqlnl 241 erdhlidais kyidpnelvp kgrllhllkq aikyqqsqdi fniidpddda sfsspphrin 301 llqdnfshdl tvtfqewkti qdttdeiwfl tfspngkyla satsessrgy fitvydveqd 361 fkiyktcvsl sqsvlylmfs pdsrylvacp fsedvtiydm natslpdasa tdsfllypst 421 rlspmdsfkl dtttypddte ssassssrpa nansnqsrvw ccdafhtaer agwmvvgspd 481 reaivhsltt keslfslkgr tcialghden isgrksidpa kvlykptssn gnwqyvedde 541 tfprvhdvki syddkyvllm thqgvidvyd fsgfpskeel skqtvdpknf lipriarldv 601 gknmtcislp lntthqgfhr qqisesqhlv lvslqdnelq mwdykenili qkyfgqkqqh 661 fiirscfayg nklvmsgsed gkiyiwdrir gnlvsvlsgh stvmsnstkp mgkncnvvas 721 npadkemfas ggddgkikiw kisrn // LOCUS NP_009892 528 aa linear PLN 30-JUN-2025 DEFINITION Atg22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009892 VERSION NP_009892.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178683.1 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 528) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07446. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..528 /product="Atg22p" /calculated_mol_wt="58713" Region 28..484 /region_name="MFS_Atg22_like" /note="Autophagy-related protein 22 and similar proteins; member of the Major Facilitator Superfamily of transporters; cd17483" /db_xref="CDD:341036" Site order(36..37,40..41,44,112,168..169,171..173,176,212, 215..216,219,326,329..330,333..335,338,366,370,430..431, 435,439,455,458..459,462..463,466) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:341036" CDS 1..528 /gene="ATG22" /locus_tag="YCL038C" /gene_synonym="AUT4" /coded_by="NM_001178683.1:1..1587" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:17021250]" /experiment="EXISTENCE:mutant phenotype:GO:0032974 amino acid transmembrane export from vacuole [PMID:17021250]" /note="Vacuolar membrane protein; required for efflux of amino acids during autophagic body breakdown in vacuole; targeted to vacuole via AP-3 pathway; null mutation causes gradual loss of viability during starvation" /db_xref="GeneID:850319" /db_xref="SGD:S000000543" ORIGIN 1 msygtindmn esvtnyrikk aqnnikgwya ysfssepfvv savstyipll lqqfasingv 61 kvhdhsipcl setgsdsdkc vlglfnnrif vdtssfalyv fslsvlfqti ivisvsgivd 121 lwgsvkfkgr ilvwfgivga lstvaiskln dtqiyslagl yivangcfgv invvgnsllp 181 ifvkdslkcq sqgayepdkv dslttvisgr gaslgyssal ivqivsmflv askkgskqdv 241 qvavlfvgiw wfvwqlpmiw liddvtipir vddstlasar spypgeqdal gqlnwknyls 301 ygwvslfesf kharllkdvm ifliawfiis dsittinsta vlfskaelhm stlnlimisv 361 ltvvnamlga fmipqflatk frwtssqtlm yiiiwasfip fygilgfffn afglkhkfem 421 fllaiwygls lgglsavsrs vfslivppgk estffsmfsi tdkgssilgp flvglltdkt 481 hnirysfyff flllmlslpv lncldvkrgr reaeelsqvl peserrld // LOCUS NP_009893 434 aa linear PLN 30-JUN-2025 DEFINITION Sro9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009893 VERSION NP_009893.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178682.1 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 434) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07447. On Oct 2, 2003 this sequence version replaced NP_009893.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..434 /product="Sro9p" /calculated_mol_wt="47929" Region 1..434 /region_name="LHP1" /note="La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]; COG5193" /db_xref="CDD:227520" CDS 1..434 /gene="SRO9" /locus_tag="YCL037C" /coded_by="NM_001178682.1:1..1305" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10564276]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:23222640]" /experiment="EXISTENCE:mutant phenotype:GO:0006417 regulation of translation [PMID:10564276]" /note="Cytoplasmic RNA-binding protein; shuttles between nucleus and cytoplasm and is exported from the nucleus in an mRNA export-dependent manner; associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif; role in preventing L-A mycovirus pathogenesis; SRO9 has a paralog, SLF1, that arose from the whole genome duplication" /db_xref="GeneID:850320" /db_xref="SGD:S000000542" ORIGIN 1 msaetaaant atapvpevqe qesskskqvn ltpaplptss pwklapteip vstisiedld 61 atrkkknrtp tpksstatkw vpikasitvs gtkrsgskng asngnsnksk nnktaassts 121 ssnanrkkkh hqhnakkqqq mkkdgfesav geedskdats qengqstqqq qpphhrnhhh 181 shhhnsngpq rrkfhnsnna gmpqnqgfpp qfkpyqgrna rnnnnnrsky hnhfhhnqqh 241 pqqpmvklqq qfypvqpvlm ainniarqie yyfseenltv dnylrsklsk dgfaplslis 301 kfyrvvnmsf ggdtnlilaa lreivaneaa tvnvaegtla akegdnvtge akepspldky 361 fvrskswsnw lpetfetein iekelvgdal dqfmislppv pqqeeesste lasqeqetke 421 dsapvaages essl // LOCUS NP_009894 566 aa linear PLN 30-JUN-2025 DEFINITION Gfd2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009894 VERSION NP_009894.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178681.1 REFERENCE 1 (residues 1 to 566) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 566) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 566) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 566) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07448. Method: conceptual translation. FEATURES Location/Qualifiers source 1..566 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..566 /product="Gfd2p" /calculated_mol_wt="64782" Region <381..476 /region_name="DnaQ" /note="DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]; COG0847" /db_xref="CDD:440608" CDS 1..566 /gene="GFD2" /locus_tag="YCL036W" /gene_synonym="YCD6" /coded_by="NM_001178681.1:1..1701" /note="hypothetical protein; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication" /db_xref="GeneID:850321" /db_xref="SGD:S000000541" ORIGIN 1 mqvqkmvrdn snngsdksvh werrnnngag pryrsrsgnt galatklsng tlsvrglvkd 61 rtgsgkiagc veafldartq lntpwdrakc nwldqidyyv qlrktafske ldqlrkpmid 121 ayvaemrqkf dasygqsraq leaklaqvds ewhmvhgdvh akleklveer rflkrlsdti 181 vpprskrsqr lspltkedra ncicpqpkgm sdtawfeaiq kkmlgmngti klleteqkll 241 adeknsvrkt fwpmveahsr snefaylekc irlmasqrai cfcldieafe tnqnviteig 301 isiydprenm vpsmvpitkn yhliieesle lrnqkwvcdy kdcyllgesy vlslkecvhf 361 iqslinyylv pvteedktws rafvghhvsg dlkwletigv kfpgrgyegh ldhtlllaet 421 pgdldvfild teqfyrksyg ekgsslgkil rlfeiphafl hnagndayyt lhlfmkfcdv 481 nfrkisgmdd vlkvmgqvkv wgerdvrepk vvpmsyaisi eeavknrtyr kgvkssrker 541 vcqtefgglt yfgtakdaft stlpth // LOCUS NP_009895 110 aa linear PLN 30-JUN-2025 DEFINITION dithiol glutaredoxin GRX1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009895 VERSION NP_009895.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178680.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 110) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07449. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..110 /product="dithiol glutaredoxin GRX1" /EC_number="1.11.1.9" /EC_number="2.5.1.18" /calculated_mol_wt="12249" Region 19..92 /region_name="GRX_GRXh_1_2_like" /note="Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase; cd03419" /db_xref="CDD:239511" Site order(24,27,29,73..76,87..90) /site_type="other" /note="GSH binding site [chemical binding]" /db_xref="CDD:239511" Site order(27,30) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239511" CDS 1..110 /gene="GRX1" /locus_tag="YCL035C" /coded_by="NM_001178680.1:1..333" /experiment="EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:12684511]" /experiment="EXISTENCE:direct assay:GO:0004602 glutathione peroxidase activity [PMID:11875065|PMID:12684511|PMID:18992757]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:genetic interaction:GO:0010731 protein glutathionylation [PMID:20074363]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:9571241]" /note="Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850322" /db_xref="SGD:S000000540" ORIGIN 1 mvsqetikhv kdliaeneif vasktycpyc haalntlfek lkvprskvlv lqlndmkega 61 diqaalyein gqrtvpniyi ngkhiggndd lqelretgel eellepilan // LOCUS NP_009896 354 aa linear PLN 30-JUN-2025 DEFINITION Lsb5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009896 VERSION NP_009896.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178679.1 REFERENCE 1 (residues 1 to 354) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 354) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 354) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 354) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07450. On Sep 29, 2000 this sequence version replaced NP_009896.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..354 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..354 /product="Lsb5p" /calculated_mol_wt="39741" Region 12..158 /region_name="VHS_Lsb5" /note="VHS (Vps27/Hrs/STAM) domain of LAS seventeen-binding protein 5; cd16980" /db_xref="CDD:340777" Site order(25..26,29,33,82..83) /site_type="other" /note="putative intraprotein/interprotein binding site [polypeptide binding]" /db_xref="CDD:340777" Region 219..295 /region_name="GAT_LSB5" /note="canonical GAT domain found in yeast LAS seventeen-binding protein 5 (Lsb5p) and similar proteins; cd14232" /db_xref="CDD:410580" Site order(221..222,225..226,228..229,232..233,236,247,250..251) /site_type="other" /note="putative ubiquitin binding site [polypeptide binding]" /db_xref="CDD:410580" CDS 1..354 /gene="LSB5" /locus_tag="YCL034W" /coded_by="NM_001178679.1:1..1065" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18298676]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:12388763|PMID:18298676|PMID:15651983]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:15651983]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:12388763]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:12388763]" /experiment="EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:12388763]" /experiment="EXISTENCE:physical interaction:GO:0007015 actin filament organization [PMID:10512884]" /note="Protein involved in membrane-trafficking events at plasma membrane; interacts with actin regulators Sla1p and Las17p, ubiquitin, Arf3p to couple actin dynamics to membrane trafficking processes; similar structure to GGA family of proteins with N-terminal VHS domain and GAT domain; binds Las17p, which is homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly, actin polymerization; may mediate disassembly of Pan1 complex from endocytic coat" /db_xref="GeneID:850323" /db_xref="SGD:S000000539" ORIGIN 1 mgflsdhpht aitetifriv ssrdytleve lapliqlika dhndynytvn qeeaaralrk 61 kikygnrlqq srtldlldlf isqgvkftvm ynddkllqrl rgmatnsens gsgekyepri 121 ikkcaayais wlnyitqnnl enaraysgly qlgqtvkqry skssrsrrsg ggsggrsnfm 181 ddsaddtlyq snsltsadrl yripqinmnk eaprirliis dalasavslq nsliglpkgk 241 fstddeeats kfiqarairr kvlrylqlvt egeflgslih andelvaalt ayddrsaqdd 301 ssdesdhgsy ddgiydeneq dnsryidses seeeslssyq pstisnpfgd hnki // LOCUS NP_009897 168 aa linear PLN 30-JUN-2025 DEFINITION peptide-methionine (R)-S-oxide reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009897 VERSION NP_009897.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178678.1 REFERENCE 1 (residues 1 to 168) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 168) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 168) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 168) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07451. Method: conceptual translation. FEATURES Location/Qualifiers source 1..168 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..168 /product="peptide-methionine (R)-S-oxide reductase" /EC_number="1.8.4.12" /calculated_mol_wt="19148" Region 43..167 /region_name="SelR" /note="SelR domain; pfam01641" /db_xref="CDD:460278" CDS 1..168 /gene="MXR2" /locus_tag="YCL033C" /coded_by="NM_001178678.1:1..507" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:20799725]" /experiment="EXISTENCE:direct assay:GO:0033743 peptide-methionine (R)-S-oxide reductase activity [PMID:15141092]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:11929995]" /experiment="EXISTENCE:mutant phenotype:GO:0033743 peptide-methionine (R)-S-oxide reductase activity [PMID:15141092]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11929995]" /note="Methionine-R-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan" /db_xref="GeneID:850324" /db_xref="SGD:S000000538" ORIGIN 1 mnkwsrlyvi tvrrtfpgrr nivltqywnk skkmsdesnd vkwndaltpl qlmvlrdkat 61 erpntgaylh tnesgvyhca ncdrplyssk akfdarcgwp afyeevspga ityhrdnslm 121 parveiccar cgghlghvfe gegwkqllnl pkdtrhcvns aslnlkkd // LOCUS NP_009898 346 aa linear PLN 30-JUN-2025 DEFINITION Ste50p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009898 VERSION NP_009898.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178677.1 REFERENCE 1 (residues 1 to 346) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 346) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 346) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 346) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07452. Method: conceptual translation. FEATURES Location/Qualifiers source 1..346 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..346 /product="Ste50p" /calculated_mol_wt="38840" Region 30..104 /region_name="SAM_Ste50p" /note="Ste50p, sterile alpha motif; pfam09235" /db_xref="CDD:401248" Site order(73,75,86,90,94) /site_type="other" /note="heterodimer interface EH [polypeptide binding]" /db_xref="CDD:188935" Region 226..325 /region_name="RA_STE50" /note="Ras-associating (RA) domain found in the fungal adaptor protein STE50; cd01786" /db_xref="CDD:340484" CDS 1..346 /gene="STE50" /locus_tag="YCL032W" /coded_by="NM_001178677.1:1..1041" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9742096]" /experiment="EXISTENCE:direct assay:GO:0019887 protein kinase regulator activity [PMID:10397774]" /experiment="EXISTENCE:direct assay:GO:0032093 SAM domain binding [PMID:16337230]" /experiment="EXISTENCE:genetic interaction:GO:0038066 p38MAPK cascade [PMID:9742096]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8793874]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:36538537]" /experiment="EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:9738877]" /experiment="EXISTENCE:mutant phenotype:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:11370856]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:36538537]" /experiment="EXISTENCE:physical interaction:GO:0038066 p38MAPK cascade [PMID:9742096]" /note="Adaptor protein for various signaling pathways; involved in the mating response, invasive/filamentous growth and osmotolerance; acts as an adaptor that links the G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction; localizes to cortical patches at the site of shmoo initiation, facilitating polarity establishment, and remaining at the shmoo tip during mating" /db_xref="GeneID:850325" /db_xref="SGD:S000000537" ORIGIN 1 medgkqaine gsndaspdld vngtilmnne dfsqwsvddv itwcistlev eetdplcqrl 61 rendivgdll pelclqdcqd lcdgdlnkai kfkilinkmr dsklewkddk tqedmitvlk 121 nlytttsakl qefqsqytrl rmdvldvmkt ssssspinth gvsttvpssn ntiipssdgv 181 slsqtdyfdt vhnrqspsrr espvtvfrqp slshskslhk dsknkvpqis tnqshpsavs 241 tantpgpspn ealkqlrask edscerilkn amkrhnladq dwrqyvlvic ygdqerllel 301 nekpviifkn lkqqglhpai mlrrrgdfee vammngsdnv tpggrl // LOCUS NP_009899 297 aa linear PLN 30-JUN-2025 DEFINITION Rrp7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009899 VERSION NP_009899.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178676.1 REFERENCE 1 (residues 1 to 297) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 297) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 297) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 297) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07453. Method: conceptual translation. FEATURES Location/Qualifiers source 1..297 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..297 /product="Rrp7p" /calculated_mol_wt="34339" Region 8..146 /region_name="dRRM_Rrp7p" /note="deviant RNA recognition motif (dRRM) in yeast ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins; cd12293" /db_xref="CDD:410983" Site order(8..11,13,20..21,33..36,38,54,57,59..61,120..123) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:410983" Region 176..291 /region_name="RRP7_like" /note="RRP7 domain ribosomal RNA-processing protein 7 (Rrp7p), ribosomal RNA-processing protein 7 homolog A (Rrp7A), and similar proteins; cl15166" /db_xref="CDD:449475" CDS 1..297 /gene="RRP7" /locus_tag="YCL031C" /coded_by="NM_001178676.1:1..894" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:24130456]" /experiment="EXISTENCE:direct assay:GO:0032545 CURI complex [PMID:17452446]" /experiment="EXISTENCE:direct assay:GO:0034456 UTP-C complex [PMID:17515605]" /experiment="EXISTENCE:genetic interaction:GO:0000028 ribosomal small subunit assembly [PMID:9271380]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:9271380]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:9271380]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9271380]" /note="Essential protein involved in rRNA processing and ribosome biogenesis; forms a complex with Utp22p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850326" /db_xref="SGD:S000000536" ORIGIN 1 mgiedisamk ngfivvpfkl pdhkalpksq easlhfmfak rhqssnsnes dclflvnlpl 61 lsniehmkkf vgqlcgkydt vshveellyn defglhevdl saltsdlmss tdvnekrytp 121 rntallkfvd aasinncwna lkkysnlhak hpnelfewty ttpsfttfvn fykpldidyl 181 kedihthmai feqreaqaqe dvqssivded gftlvvgknt kslnsirkki lnknplskhe 241 nkakpisnid kkakkdfyrf qvrerkkqei nqllskfked qerikvmkak rkfnpyt // LOCUS NP_009900 799 aa linear PLN 30-JUN-2025 DEFINITION trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009900 VERSION NP_009900.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178675.1 REFERENCE 1 (residues 1 to 799) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 799) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 799) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 799) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07454. On Sep 29, 2000 this sequence version replaced NP_009900.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..799 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..799 /product="trifunctional histidinol dehydrogenase/phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase" /EC_number="1.1.1.23" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /calculated_mol_wt="87590" Region 140..341 /region_name="PLN02346" /note="histidine biosynthesis bifunctional protein hisIE" /db_xref="CDD:215196" Region 374..788 /region_name="Histidinol_dh" /note="Histidinol dehydrogenase; pfam00815" /db_xref="CDD:459948" CDS 1..799 /gene="HIS4" /locus_tag="YCL030C" /coded_by="NM_001178675.1:1..2400" /experiment="EXISTENCE:direct assay:GO:0004399 histidinol dehydrogenase activity [PMID:379004]" /experiment="EXISTENCE:direct assay:GO:0004635 phosphoribosyl-AMP cyclohydrolase activity [PMID:379004]" /experiment="EXISTENCE:direct assay:GO:0004636 phosphoribosyl-ATP diphosphatase activity [PMID:379004]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000105 L-histidine biosynthetic process [PMID:14190241|PMID:5919326]" /experiment="EXISTENCE:mutant phenotype:GO:0004399 histidinol dehydrogenase activity [PMID:5919326]" /experiment="EXISTENCE:mutant phenotype:GO:0004635 phosphoribosyl-AMP cyclohydrolase activity [PMID:5919326]" /experiment="EXISTENCE:mutant phenotype:GO:0004636 phosphoribosyl-ATP diphosphatase activity [PMID:5919326]" /note="Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis" /db_xref="GeneID:850327" /db_xref="SGD:S000000535" ORIGIN 1 mvlpilplid dlaswnskke yvslvgqvll dgsslsneei lqfskeeevp lvalslpsgk 61 fsddeiiafl nngvsslfia sqdaktaehl veqlnvpker vvveengvfs nqfmvkqkfs 121 qdkivsikkl skdmltkevl gevrtdrpdg lyttlvvdqy erclglvyss kksiakaidl 181 grgvyysrsr neiwikgets gngqkllqis tdcdsdalkf iveqenvgfc hletmscfge 241 fkhglvgles llkqrlqdap eesytrrlfn dsalldakik eeaeelteak gkkelsweaa 301 dlfyfalakl vandvslkdv ennlnmkhlk vtrrkgdakp kfvgqpkaee ekltgpihld 361 vvkasdkvgv qkalsrpiqk tseimhlvnp iienvrdkgn salleytekf dgvklsnpvl 421 napfpeeyfe glteemkeal dlsienvrkf haaqlptetl evetqpgvlc srfprpiekv 481 glyipggtai lpstalmlgv paqvaqckei vfaspprksd gkvspevvyv aekvgaskiv 541 laggaqavaa maygtetipk vdkilgpgnq fvtaakmyvq ndtqalcsid mpagpsevlv 601 iadedadvdf vasdllsqae hgidsqvilv gvnlsekkiq eiqdavhnqa lqlprvdivr 661 kciahstivl cdgyeealem snqyapehli lqianandyv klvdnagsvf vgaytpescg 721 dyssgtnhtl ptygyarqys gantatfqkf itaqnitpeg lenigravmc vakkegldgh 781 rnavkirmsk lglipkdfq // LOCUS NP_009901 440 aa linear PLN 30-JUN-2025 DEFINITION Bik1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009901 VERSION NP_009901.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178674.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 440) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07455. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..440 /product="Bik1p" /calculated_mol_wt="50961" Region 8..73 /region_name="CAP_GLY" /note="CAP-Gly domain; pfam01302" /db_xref="CDD:460154" Region 193..>395 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" CDS 1..440 /gene="BIK1" /locus_tag="YCL029C" /gene_synonym="ARM5; PAC14" /coded_by="NM_001178674.1:1..1323" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:35235370|PMID:11511347|PMID:11756471]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:2277073]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:2277073]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:11511347]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11511347]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:9398684]" /experiment="EXISTENCE:direct assay:GO:0019894 kinesin binding [PMID:35235370]" /experiment="EXISTENCE:direct assay:GO:0031115 negative regulation of microtubule polymerization [PMID:20392838]" /experiment="EXISTENCE:direct assay:GO:0035371 microtubule plus-end [PMID:20392838]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:16380440]" /experiment="EXISTENCE:genetic interaction:GO:0000022 mitotic spindle elongation [PMID:7559759]" /experiment="EXISTENCE:genetic interaction:GO:0030543 2-micrometer plasmid partitioning [PMID:28004422]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:2277073]" /experiment="EXISTENCE:mutant phenotype:GO:0000743 nuclear migration involved in conjugation with cellular fusion [PMID:16380440]" /experiment="EXISTENCE:mutant phenotype:GO:0000819 sister chromatid segregation [PMID:35235370]" /experiment="EXISTENCE:mutant phenotype:GO:0007020 microtubule nucleation [PMID:33752231]" /experiment="EXISTENCE:mutant phenotype:GO:0030543 2-micrometer plasmid partitioning [PMID:28004422]" /experiment="EXISTENCE:mutant phenotype:GO:1902440 protein localization to mitotic spindle pole body [PMID:37093124]" /note="Microtubule-associated protein; component of the interface between microtubules and the kinetochore; involved in sister chromatid separation and mitotic spindle elongation; involved in karyogamy during mating; stabilizes Kip2p at microtubule plus ends and recruits Kip2p to mitotic SPBs; essential in polyploid cells but not in haploid or diploid cells; promotes plus-end directed movement of Dyn1p; ortholog of mammalian CLIP-170" /db_xref="GeneID:850328" /db_xref="SGD:S000000534" ORIGIN 1 mdryqrkigc fiqipnlgrg qlkyvgpvdt kagmfagvdl lanigkndgs fmgkkyfqte 61 ypqsglfiql qkvaslieka sisqtsrrtt meplsipknr sivrltnqfs pmddpksptp 121 mrsfritsrh sgnqqsmdqe asdhhqqqef gydnredrme vdsilssdrk anhnttsdwk 181 pdnghmndln ssevtielre aqltieklqr kqlhykrlld dqrmvleevq ptfdryeati 241 qerekeidhl kqqlelerrq qakqkqffda eneqllavvs qlheeikene ernlshnqpt 301 ganedvellk kqleqlrnie dqfelhktkw akereqlkmh ndslskeyqn lskelfltkp 361 qdssseevas ltkkleeane kikqleqaqa qtaveslpif dppapvdtta grqqwcehcd 421 tmghntaecp hhnpdnqqff // LOCUS NP_009902 405 aa linear PLN 30-JUN-2025 DEFINITION prion domain-containing protein RNQ1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009902 VERSION NP_009902.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178673.1 REFERENCE 1 (residues 1 to 405) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 405) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 405) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 405) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07456. On Sep 29, 2000 this sequence version replaced NP_009902.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..405 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..405 /product="prion domain-containing protein RNQ1" /calculated_mol_wt="42449" CDS 1..405 /gene="RNQ1" /locus_tag="YCL028W" /coded_by="NM_001178673.1:1..1218" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11511345]" /note="[PIN(+)] prion, named for [PSI+] INducibility; an infectious protein conformation that is generally an ordered protein aggregate" /db_xref="GeneID:850329" /db_xref="SGD:S000000533" ORIGIN 1 mdtdklisea eshfsqgnha eavakltsaa qsnpndeqms tiesliqkia gyvmdnrsgg 61 sdasqdraag ggssfmntlm adskgssqtq lgklallatv mthssnkgss nrgfdvgtvm 121 smlsgsgggs qsmgasglaa lasqffksgn nsqgqgqgqg qgqgqgqgqg qgsftalasl 181 assfmnsnnn nqqgqnqssg gssfgalasm assfmhsnnn qnsnnsqqgy nqsyqngnqn 241 sqgynnqqyq ggnggyqqqq gqsggafssl asmaqsylgg gqtqsnqqqy nqqgqnnqqq 301 yqqqgqnyqh qqqgqqqqqg hsssfsalas massylgnns nsnssyggqq qaneygrpqq 361 ngqqqsneyg rpqyggnqns ngqhesfnfs gnfsqqnnng nqnry // LOCUS NP_009903 512 aa linear PLN 30-JUN-2025 DEFINITION Fus1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009903 VERSION NP_009903.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178672.1 REFERENCE 1 (residues 1 to 512) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 512) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 512) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 512) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07457. On Sep 29, 2000 this sequence version replaced NP_009903.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..512 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..512 /product="Fus1p" /calculated_mol_wt="57649" Region 440..509 /region_name="SH3_Fus1p" /note="Src homology 3 domain of yeast cell fusion protein Fus1p; cd11854" /db_xref="CDD:212788" Site order(445,447,450,454,472..473,502,504,506..507) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212788" CDS 1..512 /gene="FUS1" /locus_tag="YCL027W" /coded_by="NM_001178672.1:1..1539" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:2690078]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807|PMID:12374868|PMID:3302672]" /experiment="EXISTENCE:genetic interaction:GO:0000755 cytogamy [PMID:3302672]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:3302672|PMID:3313002]" /experiment="EXISTENCE:mutant phenotype:GO:0032065 maintenance of protein location in cell cortex [PMID:18474625]" /note="Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate" /db_xref="GeneID:850330" /db_xref="SGD:S000000532" ORIGIN 1 mvatimqttt tvlttvaams ttlasnyiss qassstsvtt vttiatsirs tpsnllfsnv 61 aaqpksssas tiglsiglpi gifcfgllil lcyfylkrns vsisnppmsa tipreeeycr 121 rtnwfsrlfw qskcedqnsy snrdiekynd tqwtsgdnms skiqykiskp iipqhiltpk 181 ktvknpyaws gknisldpkv nemeeekvvd aflytkppni vhiessmpsy ndlpsqktvs 241 skktalktse kwsyesplsr wflrgstyfk dyglsktslk tptgapqlkq mkmlsriskg 301 yfnesdimpd erspileynn tpldandsvn nlgnttpdsq itsyrnnnid litarphsvi 361 ygttaqqtle tnfndhhdcn kstekhelii ptpskplkkr kkrrqskmyq hlqhlsrskp 421 lpltpnskyn geasvqlgkt ytviqdyepr ltdeirislg ekvkilatht dgwclvekcn 481 tqkgsihvsv ddkrylnedr givpgdclqe yd // LOCUS NP_065436 193 aa linear PLN 30-JUN-2025 DEFINITION putative nitroreductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_065436 VERSION NP_065436.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184449.1 REFERENCE 1 (residues 1 to 193) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 193) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 193) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 193) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07458. Method: conceptual translation. FEATURES Location/Qualifiers source 1..193 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..193 /product="putative nitroreductase" /calculated_mol_wt="20863" Region 7..192 /region_name="Frm2-like" /note="nitroreductase family protein; cd02140" /db_xref="CDD:380317" Site order(7,10..12,14,22,28..30,34,38..40,42..43,45,49,51, 53..60,62,119..120,122..123,125..127,130..131,134..135,138, 147,160,164,167,183..185,187,189..192) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:380317" Site order(14..16,18,45..49,120,123,127,133,145..147,182) /site_type="other" /note="FMN binding site [chemical binding]" /db_xref="CDD:380317" CDS 1..193 /gene="HBN1" /locus_tag="YCL026C-B" /gene_synonym="YCL027C-A" /coded_by="NM_001184449.1:1..582" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850331" /db_xref="SGD:S000007548" ORIGIN 1 msavatylkt ltarrtiyal kpelpgeiti ndiqsvvqti iketptafns qpnraviltg 61 ethkkvwdev tkaiespagq krpasardea fgsvifftdd kvteklkadf payaaafpsf 121 adhtsgaaqi nswvaleamg lgghlqhyng yikaalpski peswtvqaql vfgtpaappg 181 ektyikndve ifn // LOCUS NP_009904 193 aa linear PLN 30-JUN-2025 DEFINITION type II nitroreductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009904 VERSION NP_009904.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178713.1 REFERENCE 1 (residues 1 to 193) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 193) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 193) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 193) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07459. On Sep 29, 2000 this sequence version replaced NP_009904.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..193 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..193 /product="type II nitroreductase" /EC_number="1.7.1.9" /calculated_mol_wt="21101" Region 7..192 /region_name="Frm2-like" /note="nitroreductase family protein; cd02140" /db_xref="CDD:380317" Site order(7,10..12,14,22,28..30,34,38..40,42..43,45,49,51, 53..60,62,119..120,122..123,125..127,130..131,134..135,138, 147,158,160,164,167,183..185,187,189..192) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:380317" Site order(14..16,18,45..49,120,123,127,133,145..147,182) /site_type="other" /note="FMN binding site [chemical binding]" /db_xref="CDD:380317" CDS 1..193 /gene="FRM2" /locus_tag="YCL026C-A" /gene_synonym="YCLX08C" /coded_by="NM_001178713.1:1..582" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016651 oxidoreductase activity, acting on NAD(P)H [PMID:22687599]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:19904831]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:19904831]" /experiment="EXISTENCE:mutant phenotype:GO:0045922 negative regulation of fatty acid metabolic process [PMID:8701605]" /note="Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin" /db_xref="GeneID:850332" /db_xref="SGD:S000000589" ORIGIN 1 msptgnylna itnrrtiynl kpelpqgvgl ddvkrtvhvi lkntptafns qvnraviivg 61 dthkriwdav asamptaeak krpescrdea ygsvifftde gpteklqrdf palaaafptc 121 aahttgavqi qswtalellg lganlqhynd yvksalpqdv piawtvqsql vfgvptalpe 181 ektfinnvin vyh // LOCUS NP_009905 633 aa linear PLN 30-JUN-2025 DEFINITION amino acid transporter AGP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009905 VERSION NP_009905.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178671.1 REFERENCE 1 (residues 1 to 633) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 633) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 633) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 633) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07460. On Jan 23, 2006 this sequence version replaced NP_009905.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..633 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..633 /product="amino acid transporter AGP1" /calculated_mol_wt="69541" Region 117..597 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..633 /gene="AGP1" /locus_tag="YCL025C" /gene_synonym="WAP1; YCC5" /coded_by="NM_001178671.1:1..1902" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27226538]" /experiment="EXISTENCE:direct assay:GO:0006865 amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015171 amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:10654085]" /experiment="EXISTENCE:genetic interaction:GO:0015193 L-proline transmembrane transporter activity [PMID:14968425]" /experiment="EXISTENCE:genetic interaction:GO:0098718 serine import across plasma membrane [PMID:32845888]" /experiment="EXISTENCE:mutant phenotype:GO:0098718 serine import across plasma membrane [PMID:32845888]" /note="Broad-specificity, low-affinity amino acid permease; minor serine permease with major contributions from paralog Gnp1p; involved in uptake of asparagine, glutamine, and other amino acids; expression induced by amino acids and regulated by SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)" /db_xref="GeneID:850333" /db_xref="SGD:S000000530" ORIGIN 1 mssskslyel kdlknsstei hatgqdneie yfetgsndrp ssqphlgyeq hntsavrrff 61 dsfkradqgp qdeveatqmn dltsaispss rqaqelekne ssdnigantg hksdslkkti 121 qprhvlmial gtgigtgllv gngtalvhag paglligyai mgsilyciiq acgemalvys 181 nltggynayp sflvddgfgf avawvyclqw lcvcplelvt asmtikywtt svnpdvfvii 241 fyvlvitini fgargyaeae fffncckilm mtgffilgii idvggagndg figgkywhdp 301 gafngkhaid rfkgvaatlv taafafggse fiaittaeqs nprkaipgaa kqmiyrilfl 361 flatiillgf lvpynsdqll gstgggtkas pyviavashg vrvvphfina villsvlsma 421 nssfyssarl fltlseqgya pkvfsyidra grpliamgvs alfaviafca aspkeeqvft 481 wllaisglsq lftwtaicls hlrfrramkv qgrslgelgf ksqtgvwgsa yacimmilil 541 iaqfwvaiap igegkldaqa ffenylampi lialyvgykv whkdwklfir adkidldshr 601 qifdeelikq edeeyrerlr ngpywkrvva fwc // LOCUS NP_009907 1037 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009907 VERSION NP_009907.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178670.1 REFERENCE 1 (residues 1 to 1037) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1037) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1037) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1037) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07461. On Sep 29, 2000 this sequence version replaced NP_009907.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1037 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1037 /product="serine/threonine protein kinase" /EC_number="2.7.11.1" /calculated_mol_wt="116344" Region 19..285 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(27..30,33,35,48,50,90,106..109,152,156..157,159, 169..170) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" Region 920..1034 /region_name="Kcc4p_like_C" /note="C-terminal kinase associated domain 1 (KA1), a phospholipid binding domain, of Kcc4p and similar proteins; cd12194" /db_xref="CDD:213379" Site order(930,959,964,978,1007,1010,1016,1020) /site_type="other" /note="putative phospholipid binding site [chemical binding]" /db_xref="CDD:213379" CDS 1..1037 /gene="KCC4" /locus_tag="YCL024W" /coded_by="NM_001178670.1:1..3114" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15901837]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15282802|PMID:9925642]" /experiment="EXISTENCE:direct assay:GO:0005940 septin ring [PMID:15901837]" /experiment="EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:15901837]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:9925642]" /experiment="EXISTENCE:mutant phenotype:GO:0007117 budding cell bud growth [PMID:9925642]" /experiment="EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:9925642]" /note="Protein kinase of the bud neck involved in the septin checkpoint; associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p; KCC4 has a paralog, GIN4, that arose from the whole genome duplication" /db_xref="GeneID:850334" /db_xref="SGD:S000000529" ORIGIN 1 mtvanteths aakpsstigp wklgetlgfg stgkvqlaqh ertghrtavk visksifnnn 61 gnhsnddsvl pyniereivi mkllshpnvl slydvwetnn nlylileyae kgelfnllvd 121 hgplpereai ncfrqiiigi sychalgivh rdlkpenlll dsfynikiad fgmaalqtda 181 dlletscgsp hyaapeivsg lpyegfasdv wscgvilfal ltgrlpfdee ngnvrdlllk 241 vqkgqfempn dteisrdaqd ligkilvvdp rqrikirdil shpllkkyqt ikdsksikdl 301 prentylypl adsnnhtsas iddsilqnlv vlwhgrhadd ivsklkengt nkekilyall 361 yrfkldsvrg snkknrnkik ktkknkrsst lsssssllln nrsiqstprr rtskrhsref 421 sssrkrssfl lssnptdssp iplrsskrit hinvasantq atpsgvpnph krnskkrssk 481 rlsympntkr ssltskslsn ftnliddddw eyiekdakrt ssnfatlide ifepekfela 541 krekaelqrk vqeakrqsvn aqkinedefg sevsdgmkel kkindkvssp linyefsqqe 601 llqdidtllt nryqlssytr pisrldpglt pvtetlpnnl kektallqdt ekkiietirr 661 skflgsllnv rgglspgkse lapieespiv sttpliyndr meprrisdve vphftrkskh 721 fttannrrsv lslyakdsik dlnefliked pdlppqgstd nesrsedpei aesitdsrni 781 qydeddskdg dnvnndnils dfpqgvgisq eydmkdknpn qspisksaep tlvvklpsls 841 sfqgknasgl glyqrepskv tlpsltsnns svgeniedga ekgtesekia aslsdddlke 901 dndkkdndtv napttvkkpp nsvllkkfsk gkileleiha kipekrlyeg lhkllegwkq 961 yglknlvfni tnmiitgklv ndsilflrst lfeimvlpng dgrslikfnk ktgstktltk 1021 lateiqiilq kegvldk // LOCUS NP_065437 125 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCL021W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_065437 VERSION NP_065437.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184450.1 REFERENCE 1 (residues 1 to 125) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 125) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 125) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 125) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07462. Method: conceptual translation. FEATURES Location/Qualifiers source 1..125 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..125 /product="uncharacterized protein" /calculated_mol_wt="14483" CDS 1..125 /locus_tag="YCL021W-A" /coded_by="NM_001184450.1:1..378" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the vacuole" /db_xref="GeneID:850338" /db_xref="SGD:S000007549" ORIGIN 1 mvltdaeelr spvitsdmsf fdlesnhssd svhllcekyt hklpiesesq ttfrlaptkq 61 rlyrqstlyv plslkqrvfl ftervksiwa glprckpnky fkvafalavl tplaiwifyi 121 dfrvh // LOCUS NP_009910 438 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009910 VERSION NP_009910.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178667.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 438) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07464. On Sep 29, 2000 this sequence version replaced NP_009910.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..438 /product="gag protein" /calculated_mol_wt="49710" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..438 /locus_tag="YCL020W" /coded_by="NM_001178667.1:1..1317" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:850339" /db_xref="SGD:S000000525" ORIGIN 1 mesqqlhqnp rslhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqnq hsevpqaetk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyqrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lrpateri // LOCUS NP_009909 1770 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009909 VERSION NP_009909.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178666.2 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1770) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07463. On Sep 29, 2000 this sequence version replaced NP_009909.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1770 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="201966" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 574..641 /region_name="gag_pre-integrs" /note="GAG-pre-integrase domain; pfam13976" /db_xref="CDD:372857" Region 660..761 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1285..>1468 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1621..1757 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1625..1628,1662..1664,1667,1700,1727,1754) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1770 /locus_tag="YCL019W" /coded_by="join(NM_001178666.2:1..1290, NM_001178666.2:1292..5314)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:850340" /db_xref="SGD:S000000524" ORIGIN 1 mesqqlhqnp rslhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqnq hsevpqaetk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyqrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lgqqqkeskp thtidsndel pdhllidsga sqtlvrsahy lhhatpnsei 481 nivdaqkqdi pinaignlhf nfqngtktsi kalhtpniay dllslselan qnitacftrn 541 tlersdgtvl apivkhgdfy wlskkylips hiskltinnv nksksvnkyp yplihrmlgh 601 anfrsiqksl kknavtylke sdiewsnast yqcpdcligk stkhrhvkgs rlkyqesyep 661 fqylhtdifg pvhhlpksap syfisftdek trfqwvyplh drreesilnv ftsilafikn 721 qfnarvlviq mdrgseytnk tlhkfftnrg itacytttad srahgvaerl nrtllndcrt 781 llhcsglpnh lwfsavefst iirnslvspk ndksarqhag lagldittil pfgqpvivnn 841 hnpdskihpr gipgyalhps rnsygyiiyl pslkktvdtt nyvilqdkqs kldqfnydtl 901 tfdddlnrlt ahnqsfieqn eteqsydqnt esdhdyqsei einsdplvnd fssqsinplq 961 ldkepvqkvr apkevdadis eynilpspvr srtphiinke stemggtves dttsprhsst 1021 ftarnqkrpg spndmidlts qdrvnyglen ikttrlggte epyiqrnsdt nikyrttnst 1081 psiddrssns esttpiisie tkavcdntps idtdppeyrs sdhatpnimp dkssknvtad 1141 silddlplpd lthqsptdts dvskdiphih srqtnsslgg mddsnvlttt kskkrsledn 1201 eteievsrdt wnnknmrsle pprskkrinl iaaikgvksi kpvrttlryd eaitynkdnk 1261 ekdryveayh keisqllkmn twdtnkyydr ndidpkkvin smfifnkkrd gthkarfvar 1321 gdiqhpdtyd sdmqsntvhh yalmtslsia ldndyyitql dissaylyad ikeelyirpp 1381 phlglndkll rlrkslyglk qsganwyeti ksylinccdm qevrgwscvf knsqvticlf 1441 vddmilfskd lnankkiitt lkkqydtkii nlgesdneiq ydilgleiky qrskymklgm 1501 ekslteklpk lnvplnpkgk klrapgqpgh yidqdeleid edeykekvhe mqkliglasy 1561 vgykfrfdll yyintlaqhi lfpsrqvldm tyeliqfmwd trdkqliwhk nkptkpdnkl 1621 vaisdasygn qpyyksqign ifllngkvig gkstkasltc tstteaeiha vseaipllnn 1681 lshlvqelnk kpiikglltd srstisiiks tneekfrnrf fgtkamrlrd evsgnnlyvy 1741 yietkkniad vmtkplpikt fklltnkwih // LOCUS NP_009911 364 aa linear PLN 30-JUN-2025 DEFINITION 3-isopropylmalate dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009911 VERSION NP_009911.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178665.1 REFERENCE 1 (residues 1 to 364) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 364) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 364) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 364) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07465. On Sep 29, 2000 this sequence version replaced NP_009911.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..364 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..364 /product="3-isopropylmalate dehydrogenase" /EC_number="1.1.1.85" /calculated_mol_wt="38822" Region 6..359 /region_name="leuB" /note="3-isopropylmalate dehydrogenase; TIGR00169" /db_xref="CDD:272939" CDS 1..364 /gene="LEU2" /locus_tag="YCL018W" /coded_by="NM_001178665.1:1..1095" /experiment="EXISTENCE:direct assay:GO:0003862 3-isopropylmalate dehydrogenase activity [PMID:3071718]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:4355481]" /experiment="EXISTENCE:mutant phenotype:GO:0003862 3-isopropylmalate dehydrogenase activity [PMID:6297759]" /experiment="EXISTENCE:mutant phenotype:GO:0006097 glyoxylate cycle [PMID:23642236]" /experiment="EXISTENCE:mutant phenotype:GO:0009098 L-leucine biosynthetic process [PMID:6297759]" /note="Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate" /db_xref="GeneID:850342" /db_xref="SGD:S000000523" ORIGIN 1 msapkkivvl pgdhvgqeit aeaikvlkai sdvrsnvkfd fenhliggaa idatgvplpd 61 ealeaskkad avllgavggp kwgtgsvrpe qgllkirkel qlyanlrpcn fasdslldls 121 pikpqfakgt dfvvvrelvg giyfgkrked dgdgvawdse qytvpevqri trmaafmalq 181 hepplpiwsl dkanvlassr lwrktveeti knefptlkvq hqlidsaami lvknpthlng 241 iiitsnmfgd iisdeasvip gslgllpsas laslpdknta fglyepchgs apdlpknkvn 301 piatilsaam mlklslnlpe egkaiedavk kvldagirtg dlggsnstte vgdavaeevk 361 kila // LOCUS NP_009912 497 aa linear PLN 30-JUN-2025 DEFINITION cysteine desulfurase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009912 VERSION NP_009912.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178664.1 REFERENCE 1 (residues 1 to 497) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 497) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 497) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 497) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07466. On Sep 29, 2000 this sequence version replaced NP_009912.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..497 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..497 /product="cysteine desulfurase" /EC_number="2.8.1.7" /calculated_mol_wt="54336" Region 99..497 /region_name="AAT_I" /note="Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl18945" /db_xref="CDD:450240" Site order(168..169,172,245,273,276,296,299) /site_type="other" /note="pyridoxal 5'-phosphate binding pocket [chemical binding]" /db_xref="CDD:99746" Site 299 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99746" CDS 1..497 /gene="NFS1" /locus_tag="YCL017C" /gene_synonym="SPL1" /coded_by="NM_001178664.1:1..1494" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19720832]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10406803|PMID:14576278|PMID:19720832|PMID:24769239|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0016226 iron-sulfur cluster assembly [PMID:15220327]" /experiment="EXISTENCE:direct assay:GO:0031071 cysteine desulfurase activity [PMID:15220327|PMID:12065597]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:11110795]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:10551871]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:12970193]" /experiment="EXISTENCE:mutant phenotype:GO:0034227 tRNA thio-modification [PMID:14722066|PMID:15220327]" /experiment="EXISTENCE:mutant phenotype:GO:0070903 mitochondrial tRNA thio-modification [PMID:14722066]" /experiment="EXISTENCE:physical interaction:GO:1990221 L-cysteine desulfurase complex [PMID:24045011]" /note="Cysteine desulfurase involved in iron-sulfur cluster biogenesis; required for thio-modification of mitochondrial and cytoplasmic tRNAs; involved in DNA damage response by providing iron-sulfur cluster cofactors for DNA repair enzymes; essential protein located predominantly in mitochondria" /db_xref="GeneID:850343" /db_xref="SGD:S000000522" ORIGIN 1 mlkstatrsi trlsqvynvp aatyraclvs rrfysppaag vklddnfsle thtdiqaaak 61 aqasarasas gttpdavvas gstamshayq entgfgtrpi yldmqattpt dprvldtmlk 121 fytglygnph snthsygwet ntavenarah vakminadpk eiiftsgate snnmvlkgvp 181 rfykktkkhi ittrtehkcv leaarammke gfevtflnvd dqglidlkel edairpdtcl 241 vsvmavnnei gviqpikeig aicrknkiyf htdaaqaygk ihidvnemni dllsisshki 301 ygpkgigaiy vrrrprvrle pllsgggqer glrsgtlapp lvagfgeaar lmkkefdndq 361 ahikrlsdkl vkgllsaeht tlngspdhry pgcvnvsfay vegesllmal rdialssgsa 421 ctsaslepsy vlhalgkdda lahssirfgi grfsteeevd yvvkavsdrv kflrelsplw 481 emvqegidln sikwsgh // LOCUS NP_009913 380 aa linear PLN 30-JUN-2025 DEFINITION Dcc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009913 VERSION NP_009913.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178663.1 REFERENCE 1 (residues 1 to 380) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 380) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 380) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 380) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07467. On Sep 29, 2000 this sequence version replaced NP_009913.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..380 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..380 /product="Dcc1p" /calculated_mol_wt="43943" Region 15..348 /region_name="Dcc1" /note="Sister chromatid cohesion protein Dcc1; pfam09724" /db_xref="CDD:462857" CDS 1..380 /gene="DCC1" /locus_tag="YCL016C" /coded_by="NM_001178663.1:1..1143" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:17483413]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:11389843]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16525505]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:21347277]" /experiment="EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]" /note="Subunit of a complex with Ctf8p and Ctf18p; shares some components with Replication Factor C; required for sister chromatid cohesion and telomere length maintenance" /db_xref="GeneID:850344" /db_xref="SGD:S000000521" ORIGIN 1 msinlhsape ydpsykliql tpelldiiqd pvqnhqlrfk sldkdksevv lcshdktwvl 61 kqrkhsntvl lmrefvpeqp itfdetllfg lskpymdvvg faktesefet rethgelnln 121 svpiyngeld fsdkimkrss tkvigtleel lenspcsale giskwhkigg svkdgvlcil 181 sqdflfkalh vllmsamaes ldlqhlnved thhavgkdie defnpytrei ietvlnkfav 241 qeqeaenntw rlripfiaqw ygiqalrkyv sgismpidef likwkslfpp ffpcdididm 301 lrgyhfkptd ktvqyiakst lpmdpkerfk vlfrlqsqwd ledikpliee lnsrgmkids 361 fimkyarrkr lgkktvvtsr // LOCUS NP_009914 1636 aa linear PLN 30-JUN-2025 DEFINITION Bud3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009914 VERSION NP_009914.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178662.1 REFERENCE 1 (residues 1 to 1636) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1636) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1636) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1636) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07468. On Sep 29, 2000 this sequence version replaced NP_009914.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1636 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1636 /product="Bud3p" /calculated_mol_wt="184588" Region 27..205 /region_name="Bud3_N" /note="Bud3, N-terminal; pfam12015" /db_xref="CDD:403288" Region 265..441 /region_name="RhoGEF" /note="Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; smart00325" /db_xref="CDD:214619" CDS 1..1636 /gene="BUD3" /locus_tag="YCL014W" /gene_synonym="YCL012W" /coded_by="NM_001178662.1:1..4911" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:7730410]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:25002677]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12972503]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:9744878]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:2065354]" /note="Guanine nucleotide exchange factor (GEF) for Cdc42p; activates Cdc42p in early G1, accounting for the first stage of biphasic activation, with Cdc24p accounting for the second stage in late G1; involved in the Cdc42p-mediated assembly of the axial landmark that dictates the site for the next round of budding, resulting in the axial budding pattern in haploids; localizes with septins to the bud neck contractile ring in mitosis" /db_xref="GeneID:850345" /db_xref="SGD:S000000520" ORIGIN 1 mekdlsslys ekkdkendet lfniklsksv vettplnghs lfdddkslsd wtdnvftqsv 61 fyhgsddliw gkffvcvyks pnsnklnaii fdklgtscfe svdissnsqy ypaienlsps 121 dqesnvkkci avillqrypl lspsdlsqil snksencdyd ppyagdlass cqlitavppe 181 dlgkrfftsg llqnrfvsst lldviyenne stielnnrlv fhlgeqleql fnpvteyspe 241 qteygykape delptesddd lvkaicnell qlqtnftfnl veflqkflia lrvrvlneei 301 nglsttklnr lfpptidevt rincifldsl ktaipygsle vlkacsitip yfykaytrhe 361 aatknfskdi klfirhfsnv iperevytem kiesiikgpq ekllklklii erlwkskkwr 421 pknqemakkc ynniidvids fgkldsplhs ystrvftpsg kiltelakcw pvelqykwlk 481 rrvvgvydvv dlndenkrnl lvifsdyvvf inileaesyy tsdgsnrpli sdilmnslin 541 evplpskipk lkverhcyid evlvsildks tlrfdrlkgk dsfsmvckls safissssva 601 dlitkarile kdtafhlfka srshftlyst ahelcaydse kikskfalfl nippskeile 661 vnnlhlaffa rfcsndgrdn ivildvltkh ddkhievtsd nivftiinql aieipicfss 721 lnssmakdll cvnenliknl ehqleevkhp stdehravns klsgasdfda thekkrsygt 781 ittfrsytsd lkdspsgdns nvtketkeil pvkptkkssk kpreiqkktk tnaskaehie 841 kkkpnkgkgf fgvlknvfgs kskskpspvq rvpkkisqrh pkspvkkpmt sekksspkra 901 vvsspkikkk stsfstkesq taksslrave fksddligkp pdvgngahpq entrissvvr 961 dtkyvsynps qpvtentsne knvepkadqs tkqdnisnfa dvevsassyp ekldaetddq 1021 iigkatnsss vhgnkelpdl aevttanrvs ttsagdqrid tqseflraad venlsdddeh 1081 rqnesrvfnd dlfgdfipkh yrnkqenins ssnlfpegkv pqekgvsnen tnislktned 1141 astltqklsp qaskvltens nelkdtnneg kdakdiklgd dysdketake itkpknfveg 1201 iterkeifpt iprlappask infqrspsyi elfqgmrvvl dkhdahynwk rlasqvslse 1261 glkvnteeda aiinksqdda kaermtqise vieyemqqpi ptylpkahld dsgieksddk 1321 ffeieeelke elkgsktgne dvgnnnpsns ipkiekppaf kvirtspvri igrtfedtrk 1381 yengspsdis ftydthnnde pdkrlmelkf psqdeipddr fytpaeepta efpveelpnt 1441 prsinvttsn nkstddklss gnidqkptel lddlefssfn iafgntsmst dnmkissdls 1501 snktvlgnaq kvqespsgpl iyvlpqsstk hekegflrkk qkdepiwvsp skidfadlsr 1561 rtkaltpern tvplknndsr kykytgegsi gnmtnmlltk dasyaylkdf valsddeded 1621 gkqncavggp eklkfy // LOCUS NP_976246 134 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCL012C [Saccharomyces cerevisiae S288C]. ACCESSION NP_976246 VERSION NP_976246.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184672.1 REFERENCE 1 (residues 1 to 134) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 134) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 134) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 134) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07469. Method: conceptual translation. FEATURES Location/Qualifiers source 1..134 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..134 /product="uncharacterized protein" /calculated_mol_wt="15457" Region 37..127 /region_name="DUF2015" /note="Fungal protein of unknown function (DUF2015); pfam09435" /db_xref="CDD:401406" CDS 1..134 /locus_tag="YCL012C" /gene_synonym="YCL011C-A" /coded_by="NM_001184672.1:1..405" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene" /db_xref="GeneID:2746859" /db_xref="SGD:S000029705" ORIGIN 1 mkslfylkll lwvvllslcl lmahrktkva dkfralrsri qlrfnrhirl ndsfaddlen 61 glhsrnfdii sensndvrgg lddvskneik qimendnvdf dkarllymer kfgqngiapd 121 gtpidpkaft fdsr // LOCUS NP_009916 427 aa linear PLN 30-JUN-2025 DEFINITION single-stranded telomeric DNA-binding/mRNA-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009916 VERSION NP_009916.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178660.1 REFERENCE 1 (residues 1 to 427) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 427) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 427) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 427) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07470. Method: conceptual translation. FEATURES Location/Qualifiers source 1..427 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..427 /product="single-stranded telomeric DNA-binding/mRNA-binding protein" /calculated_mol_wt="48598" Region 121..197 /region_name="RRM1_HRB1_GBP2" /note="RNA recognition motif 1 (RRM1) found in Saccharomyces cerevisiae protein HRB1, G-strand-binding protein 2 (GBP2) and similar proteins; cd21605" /db_xref="CDD:410184" Region 218..292 /region_name="RRM2_HRB1_GBP2" /note="RNA recognition motif 2 (RRM2) found in Saccharomyces cerevisiae protein HRB1, G-strand-binding protein 2 (GBP2) and similar proteins; cd21606" /db_xref="CDD:410185" Region 347..425 /region_name="RRM3_HRB1_GBP2" /note="RNA recognition motif 3 (RRM3) found in Saccharomyces cerevisiae protein HRB1, G-strand-binding protein 2 (GBP2) and similar proteins; cd21607" /db_xref="CDD:410186" CDS 1..427 /gene="GBP2" /locus_tag="YCL011C" /gene_synonym="RLF6" /coded_by="NM_001178660.1:1..1284" /experiment="EXISTENCE:direct assay:GO:0000723 telomere maintenance [PMID:12519786]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:14769921]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:14769921|PMID:12634846|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26359986|PMID:12634846|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:33910495|PMID:18981231|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:7800479|PMID:7777547]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:12519786]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:12519786]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:12634846]" /experiment="EXISTENCE:mutant phenotype:GO:0043047 single-stranded telomeric DNA binding [PMID:7777547]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:24452287]" /note="Poly(A+) RNA-binding guard protein involved in translation repression; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; relocalizes to the cytosol in response to hypoxia; GBP2 has a paralog, HRB1, that arose from the whole genome duplication" /db_xref="GeneID:850346" /db_xref="SGD:S000000517" ORIGIN 1 merelgmygn drsrsrspvr rrlsddrdry ddyndsssnn gngsrrqrrd rgsrfndryd 61 qsyggsryhd drnwpprrgg rgrggsrsfr ggrgggrgrt lgpiverdle rqfdatkrnf 121 ensifvrnlt fdctpedlke lfgtvgevve adiitskghh rgmgtveftk nesvqdaisk 181 fdgalfmdrk lmvrqdnppp eaakefskka treeidngfe vfiinlpysm nwqslkdmfk 241 ecghvlradv eldfngfsrg fgsviypted emiraidtfn gmevegrvle vregrfnkrk 301 nndrynqrre dledtrgtep glaqdaavhi detaakfteg vnpggdrncf iycsnlpfst 361 arsdlfdlfg pigkinnael kpqengqptg vavveyenlv dadfciqkln nynyggcslq 421 isyarrd // LOCUS NP_009917 259 aa linear PLN 30-JUN-2025 DEFINITION Sgf29p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009917 VERSION NP_009917.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178659.1 REFERENCE 1 (residues 1 to 259) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 259) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 259) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 259) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07471. Method: conceptual translation. FEATURES Location/Qualifiers source 1..259 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..259 /product="Sgf29p" /calculated_mol_wt="29250" Region 127..250 /region_name="DUF1325" /note="SGF29 tudor-like domain; pfam07039" /db_xref="CDD:462071" CDS 1..259 /gene="SGF29" /locus_tag="YCL010C" /coded_by="NM_001178659.1:1..780" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:12052880]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:21685874]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:22224423]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:21685874]" /experiment="EXISTENCE:mutant phenotype:GO:0072742 SAGA complex localization to transcription regulatory region [PMID:21685874]" /experiment="EXISTENCE:mutant phenotype:GO:0140671 ADA complex [PMID:21734642]" /experiment="EXISTENCE:physical interaction:GO:0140671 ADA complex [PMID:21734642]" /note="Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA and TBP recruitment to target promoters and H3 acetylation" /db_xref="GeneID:850347" /db_xref="SGD:S000000516" ORIGIN 1 mdgywdvvvs slqdiynane vipfddelqt kklnflnmsk dqlqlhlntf qehmenvnrv 61 hrildnvrsn lslmlnqsre ekseenteda eegegtrmal sqgkkavgkv grsywtseyn 121 pnapilvgse vaykprrgsa dgewiqcevl kvvadgtrfe vrdpepdelg nsgkvykcnr 181 kelllippgf ptknyppgtk vlarypettt fypaivigtk rdgtcrlrfd geeevdkete 241 vtrrlvlpsp talanlark // LOCUS NP_009918 309 aa linear PLN 30-JUN-2025 DEFINITION acetolactate synthase regulatory subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_009918 VERSION NP_009918.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178658.1 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 309) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07472. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..309 /product="acetolactate synthase regulatory subunit" /calculated_mol_wt="33856" Region 77..282 /region_name="acolac_sm" /note="acetolactate synthase, small subunit; TIGR00119" /db_xref="CDD:272916" CDS 1..309 /gene="ILV6" /locus_tag="YCL009C" /coded_by="NM_001178658.1:1..930" /experiment="EXISTENCE:direct assay:GO:0003984 acetolactate synthase activity [PMID:8972574|PMID:16390333]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005948 acetolactate synthase complex [PMID:10213630]" /experiment="EXISTENCE:direct assay:GO:0009082 branched-chain amino acid biosynthetic process [PMID:8972574]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:8972574]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:mutant phenotype:GO:0003984 acetolactate synthase activity [PMID:16390333]" /note="Regulatory subunit of acetolactate synthase; acetolactate synthase catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria" /db_xref="GeneID:850348" /db_xref="SGD:S000000515" ORIGIN 1 mlrsllqsgh rrvvasscat mvrcssssts alaykqmhrh atrpplptld tpswnansav 61 ssiiyetpap srqprkqhvl nclvqnepgv lsrvsgtlaa rgfnidslvv cntevkdlsr 121 mtivlqgqdg vveqarrqie dlvpvyavld ytnseiikre lvmarisllg teyfedlllh 181 hhtstnagaa dsqelvaeir ekqfhpanlp asevlrlkhe hlnditnltn nfggrvvdis 241 etscivelsa kptrisaflk lvepfgvlec arsgmmalpr tplktsteea adedekisei 301 vdisqlppg // LOCUS NP_009919 385 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-binding ESCRT-I subunit protein STP22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009919 VERSION NP_009919.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178657.1 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 385) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07473. On Feb 23, 2004 this sequence version replaced NP_009919.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..385 /product="ubiquitin-binding ESCRT-I subunit protein STP22" /calculated_mol_wt="43199" Region 31..156 /region_name="UEV" /note="UEV domain; pfam05743" /db_xref="CDD:399041" Region 316..375 /region_name="Vps23_core" /note="Vps23 core domain; pfam09454" /db_xref="CDD:462803" CDS 1..385 /gene="STP22" /locus_tag="YCL008C" /gene_synonym="AGS1; VPL15; VPS23" /coded_by="NM_001178657.1:1..1158" /experiment="EXISTENCE:direct assay:GO:0000813 ESCRT I complex [PMID:15044434]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:11511343]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009898 cytoplasmic side of plasma membrane [PMID:20028738]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:19380877]" /experiment="EXISTENCE:direct assay:GO:0061709 reticulophagy [PMID:31802527]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:11511343]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:11511343]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:17145965]" /experiment="EXISTENCE:mutant phenotype:GO:1902915 negative regulation of protein polyubiquitination [PMID:23645667]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0000813 ESCRT I complex [PMID:16615894]" /note="Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; prevents polyubiquitination of the arrestin-related protein Rim8p, thereby directing its monoubiquitination by Rsp5p; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype" /db_xref="GeneID:850349" /db_xref="SGD:S000000514" ORIGIN 1 msangkisvp eavvnwlfkv iqpiyndgrt tfhdslalld nfhslrprtr vfthsdgtpq 61 lllsiygtis tgedgssphs ipvimwvpsm ypvkppfisi nlenfdmnti ssslpiqeyi 121 dsngwialpi lhcwdpaamn limvvqelms llheppqdqa pslppkpntq lqqeqntppl 181 ppkpksphlk pplppppppq pasnaldlmd mdntdisptn hhemlqnlqt vvnelyredv 241 dyvadkiltr qtvmqesiar fheiiaidkn hlraveqaie qtmhslnaqi dvltanrakv 301 qqfsstshvd dedvnsiava ktdglnqlyn lvaqdyaltd tieclsrmlh rgtipldtfv 361 kqgrelarqq flvrwhiqri tspls // LOCUS NP_958835 73 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V0 sector ATPase subunit e [Saccharomyces cerevisiae S288C]. ACCESSION NP_958835 VERSION NP_958835.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184518.1 REFERENCE 1 (residues 1 to 73) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 73) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 73) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 73) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07474. Method: conceptual translation. FEATURES Location/Qualifiers source 1..73 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..73 /product="H(+)-transporting V0 sector ATPase subunit e" /calculated_mol_wt="8250" Region 6..63 /region_name="ATP_synt_H" /note="ATP synthase subunit H; pfam05493" /db_xref="CDD:461663" CDS 1..73 /gene="VMA9" /locus_tag="YCL005W-A" /gene_synonym="CWH36; LDB10" /coded_by="NM_001184518.1:1..222" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:14734024]" /experiment="EXISTENCE:mutant phenotype:GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain [PMID:14970230]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:14970230]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:14970230]" /experiment="EXISTENCE:mutant phenotype:GO:0042625 ATPase-coupled ion transmembrane transporter activity [PMID:14970230]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:14970230]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:16569636]" /experiment="EXISTENCE:physical interaction:GO:0065003 protein-containing complex assembly [PMID:16569636]" /note="Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis" /db_xref="GeneID:2732686" /db_xref="SGD:S000028508" ORIGIN 1 mssfytvvgv fivvsamsvl fwimapknnq avwrstvilt lammflmwai tflcqlhplv 61 aprrsdlrpe fae // LOCUS NP_009922 256 aa linear PLN 30-JUN-2025 DEFINITION Ldb16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009922 VERSION NP_009922.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178654.1 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 256) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07475. On Sep 29, 2000 this sequence version replaced NP_009922.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..256 /product="Ldb16p" /calculated_mol_wt="28893" CDS 1..256 /gene="LDB16" /locus_tag="YCL005W" /coded_by="NM_001178654.1:1..771" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:39622802]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:24434579]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:26572621]" /experiment="EXISTENCE:mutant phenotype:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:31594806]" /note="Protein involved in lipid droplet (LD) assembly; forms a complex with Sei1p at ER-LD contact sites, stabilizing contact sites; ensures that LDs bud from the ER towards the cytosolic side of the membrane; null mutants have decreased net negative cell surface charge and localized accumulation of phosphatidic acid (PA) marker proteins; GFP-fusion protein expression is induced in response to MMS; null mutant can be complemented by the human seipin, BSCL2" /db_xref="GeneID:850351" /db_xref="SGD:S000000511" ORIGIN 1 mfvvdwsvql cmgvisplfr alvqlplsif vwngfqlval piniplrlfl gtslsrlvaq 61 tstldfyvvl tlfqyfavlc afgsiiglif gfilgvfhsi cgvpsvyisl ewkrwfapir 121 tvlerastsi vnimrgqtia pipmpkpnpt hiskpnmkkf hdepgaddmt ithdvncyit 181 pcqtptneki qhynndsfnt tttddeptdi wdrsdtyqns fvtnetlmsl snraklrrna 241 sdadivniki lrrnsr // LOCUS NP_009923 521 aa linear PLN 30-JUN-2025 DEFINITION CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009923 VERSION NP_009923.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178653.1 REFERENCE 1 (residues 1 to 521) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 521) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 521) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 521) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07476. On Sep 29, 2000 this sequence version replaced NP_009923.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..521 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..521 /product="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase" /EC_number="2.7.8.5" /calculated_mol_wt="59239" Region 64..230 /region_name="PLDc_PGS1_euk_1" /note="Catalytic domain, repeat 1, of eukaryotic PhosphatidylGlycerophosphate Synthases; cd09135" /db_xref="CDD:197233" Site order(64,66,170..174,178..184,194,196,206..210,212,214,218, 222..223,226,230) /site_type="other" /note="putative domain interface [polypeptide binding]" /db_xref="CDD:197233" Site order(182,184,196,198,209) /site_type="active" /note="putative active site [active]" /db_xref="CDD:197233" Site 182 /site_type="active" /note="catalytic site [active]" /db_xref="CDD:197233" Region 295..498 /region_name="PLDc_PGS1_euk_2" /note="Catalytic domain, repeat 2, of eukaryotic phosphatidylglycerophosphate synthases; cd09137" /db_xref="CDD:197235" Site order(295..301,303,421..425,447..450,456,460..467,469,475, 478,482,485..486) /site_type="other" /note="putative domain interface [polypeptide binding]" /db_xref="CDD:197235" Site order(424,426,450,452,463) /site_type="active" /note="putative active site [active]" /db_xref="CDD:197235" Site 424 /site_type="active" /note="catalytic site [active]" /db_xref="CDD:197235" CDS 1..521 /gene="PGS1" /locus_tag="YCL004W" /gene_synonym="PEL1; YCL003W" /coded_by="NM_001178653.1:1..1566" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9799363]" /experiment="EXISTENCE:mutant phenotype:GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity [PMID:9545322]" /experiment="EXISTENCE:mutant phenotype:GO:0032049 cardiolipin biosynthetic process [PMID:9545322]" /note="Phosphatidylglycerolphosphate synthase; catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis" /db_xref="GeneID:850352" /db_xref="SGD:S000000510" ORIGIN 1 mttrllqltr phyrllslpl qkpfnikrqm saanpspfgn ylntitkslq qnlqtcfhfq 61 akeidiiesp sqfydllktk ilnsqnrifi aslylgkset elvdcisqal tknpklkvsf 121 lldglrgtre lpsacsatll sslvakygse rvdcrlyktp ayhgwkkvlv pkrfneglgl 181 qhmkiygfdn evilsganls ndyftnrqdr yylfksrnfs nyyfklhqli ssfsyqiikp 241 mvdgsiniiw pdsnptvept knkrlflrea sqlldgflks skqslpitav gqfstlvypi 301 sqftplfpky ndkstekrti lsllstitsn aiswtftagy fnilpdikak llatpvaean 361 vitaspfang fyqskgvssn lpgaylylsk kflqdvcryr qdhaitlrew qrgvvnkpng 421 wsyhakgiwl sardkndann wkpfitvigs snytrraysl dlesnaliit rdeelrkkmk 481 aeldnllqyt kpvtledfqs dperhvgtgv kiatsilgkk l // LOCUS NP_009924 263 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCL002C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009924 VERSION NP_009924.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178652.2 REFERENCE 1 (residues 1 to 263) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 263) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 263) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 263) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07477. On Apr 26, 2011 this sequence version replaced NP_009924.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..263 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..263 /product="uncharacterized protein" /calculated_mol_wt="30066" CDS 1..263 /locus_tag="YCL002C" /coded_by="NM_001178652.2:1..792" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; YCL002C is not an essential gene" /db_xref="GeneID:850353" /db_xref="SGD:S000000508" ORIGIN 1 mlvivlqgla gflsiiailc qkrynklhrs iyglsydlfl ldfvgnglyl ycalhycyss 61 lvreqlsqrf plfyplndar sipissflil kdfcvscccm mvlrqlyyyr stkhiyqgis 121 itsiiiisvf lvlgiftygc sisnlplkns gkfgvfyleh inylwvmanl lkcfkyvpqm 181 sinwmgcstv glsskfalis flaesidllg rlviptnalf yeipfnstpf wvkliqfvtl 241 lvilcqvqyv yvgrkprlpk gkl // LOCUS NP_009925 188 aa linear PLN 30-JUN-2025 DEFINITION protein retrieval receptor [Saccharomyces cerevisiae S288C]. ACCESSION NP_009925 VERSION NP_009925.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178651.1 REFERENCE 1 (residues 1 to 188) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 188) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 188) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 188) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07478. Method: conceptual translation. FEATURES Location/Qualifiers source 1..188 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..188 /product="protein retrieval receptor" /calculated_mol_wt="22139" Region 1..183 /region_name="RER1" /note="Golgi protein involved in Golgi-to-ER retrieval [Intracellular trafficking and secretion]; COG5249" /db_xref="CDD:227574" CDS 1..188 /gene="RER1" /locus_tag="YCL001W" /coded_by="NM_001178651.1:1..567" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:22761830]" /experiment="EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11238450]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:11238450]" /experiment="EXISTENCE:mutant phenotype:GO:0006621 protein retention in ER lumen [PMID:8707815]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11238450]" /experiment="EXISTENCE:mutant phenotype:GO:0030137 COPI-coated vesicle [PMID:11238450]" /note="Protein involved in retention of membrane proteins; including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER" /db_xref="GeneID:850354" /db_xref="SGD:S000000507" ORIGIN 1 mdydssdtmn ggssnplitk mntmkllyqh yldkvtphak erwavlggll clfmvritma 61 egwyvicygl glfllnqfla fltpkfdmsl qqdeennele agekseefrp firrlpefkf 121 wynsiratvi slllslfsif dipvfwpill myfillfflt mrrqiqhmik yryipldigk 181 kkyshssn // LOCUS NP_009926 153 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCL001W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_009926 VERSION NP_009926.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184314.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 153) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07479. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..153 /product="uncharacterized protein" /calculated_mol_wt="17686" Region 17..>116 /region_name="aRF1/eRF1" /note="peptide chain release factor 1, archaeal and eukaryotic forms; cl42864" /db_xref="CDD:456209" CDS 1..153 /locus_tag="YCL001W-A" /coded_by="NM_001184314.1:1..462" /note="hypothetical protein; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III" /db_xref="GeneID:850355" /db_xref="SGD:S000007221" ORIGIN 1 mtflqfinnn rqegqgyise klfktkknem irktvtnlva vrlknlshef dvienylryi 61 astsehlfta ikrhfnkcar kllkeaidsk snsetatvvl qegfsgicll kassiilklk 121 lkfpkkkdrt disklcdkke rmtqwleisi lmn // LOCUS NP_076878 84 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCL001W-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_076878 VERSION NP_076878.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184462.1 REFERENCE 1 (residues 1 to 84) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 84) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 84) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 84) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07480. Method: conceptual translation. FEATURES Location/Qualifiers source 1..84 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..84 /product="uncharacterized protein" /calculated_mol_wt="9441" Region 1..>72 /region_name="eRF1_3" /note="eRF1 domain 3; pfam03465" /db_xref="CDD:397503" CDS 1..84 /locus_tag="YCL001W-B" /coded_by="NM_001184462.1:1..255" /note="hypothetical protein; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication" /db_xref="GeneID:850356" /db_xref="SGD:S000007596" ORIGIN 1 mddflehlsk ddnkawygae eteraaklda ietllitdsv lkrndvkkre kyldliensg 61 nnngkifvls tskitvsnlt nqqi // LOCUS NP_001335748 104 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR001W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335748 VERSION NP_001335748.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348893.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 104) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80268. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..104 /product="uncharacterized protein" /calculated_mol_wt="12383" CDS 1..104 /locus_tag="YCR001W" /coded_by="NM_001348893.1:1..315" /note="hypothetical protein; conserved among S. cerevisiae strains; YCR001W is not an essential gene" /db_xref="GeneID:850357" /db_xref="SGD:S000000594" ORIGIN 1 mlyllkklkh idsygesnls mfylkfycpw klcpllpily grnksvqnaw schklhrfid 61 fptpsanmnf fffirvcygt vslfistflk kisffiyvnf tvyf // LOCUS NP_009928 322 aa linear PLN 30-JUN-2025 DEFINITION septin CDC10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009928 VERSION NP_009928.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178715.1 REFERENCE 1 (residues 1 to 322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 322) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07481. Method: conceptual translation. FEATURES Location/Qualifiers source 1..322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..322 /product="septin CDC10" /calculated_mol_wt="36894" Region 11..322 /region_name="CDC3" /note="Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5019" /db_xref="CDD:227352" CDS 1..322 /gene="CDC10" /locus_tag="YCR002C" /coded_by="NM_001178715.1:1..969" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:31990274|PMID:9884239]" /experiment="EXISTENCE:direct assay:GO:0001400 mating projection base [PMID:18552279]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:14993234]" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:22144691|PMID:18550837|PMID:29321251]" /experiment="EXISTENCE:direct assay:GO:0005545 1-phosphatidylinositol binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141|PMID:18826657]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:18826657]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0031105 septin complex [PMID:18550837]" /experiment="EXISTENCE:direct assay:GO:0032160 septin filament array [PMID:15282341]" /experiment="EXISTENCE:direct assay:GO:0042764 ascospore-type prospore [PMID:18701287]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0043934 sporulation [PMID:18701287]" /experiment="EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:15901837]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0072687 meiotic spindle [PMID:18826657]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:4950437]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:14993234]" /experiment="EXISTENCE:mutant phenotype:GO:0010458 exit from mitosis [PMID:12699621]" /experiment="EXISTENCE:physical interaction:GO:0031105 septin complex [PMID:9813094]" /note="Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress" /db_xref="GeneID:850358" /db_xref="SGD:S000000595" ORIGIN 1 mdplssvqpa syvgfdtitn qiehrllkkg fqfnimvvgq sglgkstlin tlfashlids 61 atgddisalp vtkttemkis thtlvedrvr lninvidtpg fgdfidnska wepivkyike 121 qhsqylrkel taqrerfitd trvhailyfl qpngkelsrl dvealkrlte ianvipvigk 181 sdtltldert efreliqnef ekynfkiypy dseeltdeel elnrsvrsii pfavvgsene 241 ieingetfrg rktrwsainv edinqcdfvy lreflirthl qdliettsyi hyegfrarql 301 ialkenansr ssahmssnai qr // LOCUS NP_009929 183 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL32m MRPL32 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009929 VERSION NP_009929.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178716.1 REFERENCE 1 (residues 1 to 183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 183) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07482. Method: conceptual translation. FEATURES Location/Qualifiers source 1..183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..183 /product="mitochondrial 54S ribosomal protein bL32m MRPL32" /calculated_mol_wt="21306" Region 72..>120 /region_name="Ribosomal_L32p" /note="Ribosomal L32p protein family; pfam01783" /db_xref="CDD:426430" CDS 1..183 /gene="MRPL32" /locus_tag="YCR003W" /gene_synonym="bL32m" /coded_by="NM_001178716.1:1..552" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:2060626]" /note="Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850359" /db_xref="SGD:S000000596" ORIGIN 1 mnslifgkql afhkivptta igwlvplgnp slqipgqkql gsihrwlrek lqqdhkdted 61 kdffsnngil lavpkkkvsh qkkrqklygp gkkqlkmihh lnkcpscghy krantlcmyc 121 vgqishiwkt htakeeikpr qeeelseldq rvlypgrrdt kytkdlkdkd nylerrvrtl 181 kkd // LOCUS NP_009930 247 aa linear PLN 30-JUN-2025 DEFINITION flavodoxin-like fold family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009930 VERSION NP_009930.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178717.1 REFERENCE 1 (residues 1 to 247) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 247) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 247) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 247) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07483. Method: conceptual translation. FEATURES Location/Qualifiers source 1..247 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..247 /product="flavodoxin-like fold family protein" /calculated_mol_wt="26219" Region 1..201 /region_name="FMN_red" /note="NADPH-dependent FMN reductase; cl00438" /db_xref="CDD:469770" CDS 1..247 /gene="YCP4" /locus_tag="YCR004C" /coded_by="NM_001178717.1:1..744" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21442317|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:38096056|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:38096056]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0160020 positive regulation of ferroptosis [PMID:38096056]" /note="hypothetical protein; has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:850360" /db_xref="SGD:S000000597" ORIGIN 1 mvkiaiitys tyghidvlaq avkkgveaag gkadiyrvee tlpdevltkm napqkpedip 61 vatektlley daflfgvptr fgnlpaqwsa fwdktgglwa kgslngkaag ifvstssygg 121 gqestvkacl sylahhgiif lplgyknsfa elasieevhg gspwgagtla gpdgsrtasp 181 lelriaeiqg ktfyetakkl fpakeakpst ekktttsdaa krqtkpaaat taekkedkgl 241 lscctvm // LOCUS NP_009931 460 aa linear PLN 30-JUN-2025 DEFINITION citrate (Si)-synthase CIT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009931 VERSION NP_009931.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178718.1 REFERENCE 1 (residues 1 to 460) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 460) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 460) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 460) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07484. Method: conceptual translation. FEATURES Location/Qualifiers source 1..460 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..460 /product="citrate (Si)-synthase CIT2" /EC_number="2.3.3.16" /calculated_mol_wt="51282" Region 26..452 /region_name="CS_ACL-C_CCL" /note="Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A...; cl00416" /db_xref="CDD:469765" Site order(257,261,293,339..340,348,420,440) /site_type="other" /note="oxalacetate binding site [chemical binding]" /db_xref="CDD:99858" Site order(257,261,292..293,333..334,336..340,348,392,420) /site_type="other" /note="citrylCoA binding site [chemical binding]" /db_xref="CDD:99858" Site order(291..293,296,299,333..340,389,392,394,437) /site_type="other" /note="coenzyme A binding site [chemical binding]" /db_xref="CDD:99858" Site order(293,339,394) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:99858" CDS 1..460 /gene="CIT2" /locus_tag="YCR005C" /coded_by="NM_001178718.1:1..1383" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25982115]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:25982115|PMID:16877773]" /experiment="EXISTENCE:direct assay:GO:0036440 citrate synthase activity [PMID:2181273]" /experiment="EXISTENCE:genetic interaction:GO:0006101 citrate metabolic process [PMID:12913175]" /experiment="EXISTENCE:genetic interaction:GO:0036440 citrate synthase activity [PMID:2181273]" /note="Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate; expression is controlled by Rtg1p and Rtg2p transcription factors; SCF-Ucc1 regulates level of Cit2p to maintain citrate homeostasis; oxaloacetate-dependent positive feedback loop inhibits Cit2p ubiquitination; CIT2 has a paralog, CIT1, that arose from the whole genome duplication" /db_xref="GeneID:850361" /db_xref="SGD:S000000598" ORIGIN 1 mtvpylnsnr nvasylqsns sqektlkerf seiypihaqd vrqfvkehgk tkisdvlleq 61 vyggmrgipg svwegsvldp edgirfrgrt iadiqkdlpk akgssqplpe alfwllltge 121 vptqaqvenl sadlmsrsel pshvvqlldn lpkdlhpmaq fsiavtales eskfakayaq 181 giskqdywsy tfedsldllg klpviaakiy rnvfkdgkmg evdpnadyak nlvnligskd 241 edfvdlmrly ltihsdhegg nvsahtshlv gsalsspyls lasglnglag plhgranqev 301 lewlfalkee vnddyskdti ekylwdtlns grvipgygha vlrktdprym aqrkfamdhf 361 pdyelfklvs siyevapgvl tehgktknpw pnvdahsgvl lqyyglkess fytvlfgvsr 421 afgilaqlit draigasier pksystekyk elvknieskl // LOCUS NP_001335749 157 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR006C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335749 VERSION NP_001335749.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348894.1 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 157) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80269. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..157 /product="uncharacterized protein" /calculated_mol_wt="18160" CDS 1..157 /locus_tag="YCR006C" /coded_by="NM_001348894.1:1..474" /note="hypothetical protein; conserved among S. cerevisiae strains; YCR006C is not an essential gene" /db_xref="GeneID:850362" /db_xref="SGD:S000000599" ORIGIN 1 mfirvcnrli ytptnvllit vedgrisvll wfryaipael cytrlarilr gkhcadfpqs 61 cchnisrfgv lnksvlgsfn qwlggisker kliartfdaf irwsstrgee vttyfflqkk 121 svtfsvarrl sgrqqweaqr knnnngkrny llsvtfv // LOCUS NP_009933 239 aa linear PLN 30-JUN-2025 DEFINITION DUP240 family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_009933 VERSION NP_009933.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178720.1 REFERENCE 1 (residues 1 to 239) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 239) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 239) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 239) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07485. Method: conceptual translation. FEATURES Location/Qualifiers source 1..239 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..239 /product="DUP240 family protein" /calculated_mol_wt="27433" Region 81..169 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..239 /gene="DFP3" /locus_tag="YCR007C" /coded_by="NM_001178720.1:1..720" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Putative integral membrane protein; member of DUP240 gene family; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; YCR007C is not an essential gene" /db_xref="GeneID:850364" /db_xref="SGD:S000000600" ORIGIN 1 mqphldnnsn nddvkldtlg eqnvlssaen itlpedtfks ymtyllyema hykpmifsfl 61 alsvsilivv ifhnvkacdv vfgfsifvts ilflstlipf nvyisdegfr iklllevith 121 rpavkgkewr aitdnmnqyl ldnglwstry yfyssercyk ffrflvkekp pgvnvnssvk 181 datstqidap aneasnevik cfsfssdpif eayfvkavev ekqaqqeywr kqypdadip // LOCUS NP_009934 603 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase SAT4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009934 VERSION NP_009934.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178721.1 REFERENCE 1 (residues 1 to 603) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 603) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 603) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 603) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07486. Method: conceptual translation. FEATURES Location/Qualifiers source 1..603 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..603 /product="serine/threonine protein kinase SAT4" /EC_number="2.7.11.1" /calculated_mol_wt="66535" Region 322..589 /region_name="STKc_HAL4_like" /note="Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; cd13994" /db_xref="CDD:270896" Site order(322..326,330,351,353,386,403..406,410,412,449,451, 453..454,456,467,470,490..493) /site_type="active" /db_xref="CDD:270896" Site order(322..326,330,351,353,386,403..406,410,449,451, 453..454,456,467) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270896" Site order(326,410,412,449,451,453,470,490..493) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270896" Site order(466..474,478..483,487..493) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270896" CDS 1..603 /gene="SAT4" /locus_tag="YCR008W" /gene_synonym="HAL4" /coded_by="NM_001178721.1:1..1812" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25117470]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25117470]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12518319]" /experiment="EXISTENCE:genetic interaction:GO:0008104 intracellular protein localization [PMID:21237705]" /experiment="EXISTENCE:mutant phenotype:GO:0009249 protein lipoylation [PMID:25117470]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:10207057]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:32191698]" /experiment="EXISTENCE:mutant phenotype:GO:1903329 regulation of iron-sulfur cluster assembly [PMID:25117470]" /note="Ser/Thr protein kinase involved in salt tolerance, nutrient response; functions in regulation of Trk1p-Trk2p potassium transporter; overexpression affects the Fe-S and lipoamide containing proteins in the mitochondrion; required for lipoylation of Lat1p, Kgd2p and Gcv3p; partially redundant with Hal5p; has similarity to Npr1p; localizes to the cytoplasm and mitochondrion" /db_xref="GeneID:850366" /db_xref="SGD:S000000601" ORIGIN 1 mtgmndnnaa ipqqtprkha lsskvmqlfr sgsrssrqgk assniqppsn intnvpsask 61 sakfglhtpt tatprvvsnp sntagvskpg mympeyyqsa spshssssas lnnhidints 121 ksssaaslts svsalslspt sainissksl spkfshhsns ntaitpaptp tasninnvnk 181 itntsapicg rflvhkdgth ehhlknakrq eklstmiknm vgasklrgea ksavpdiimd 241 pkttlksnkn pptlfagfmk qvvdmddkyp egaptsgaln cperdiyrsd qkdsknnthn 301 itttkkdrqc faekygrcqe vlgkgafgvv ricqkknvss qdgnksekly avkefkrrts 361 esaekyskrl tsefcisssl hhtnivttld lfqdakgeyc evmeycaggd lftlvvaagk 421 leymeadcff kqlirgvvym hemgvchrdl kpenlllthd gvlkitdfgn secfkmawek 481 nihlsggvcg sspyiapeey ikeefdprpv diwacgviym amrtgrqlws saekddpfym 541 nylkgrkekg gyepieslkr arcrnviysm ldpvpyrrin gkqilnsewg reikcchngr 601 alk // LOCUS NP_009935 265 aa linear PLN 30-JUN-2025 DEFINITION amphiphysin-like protein RVS161 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009935 VERSION NP_009935.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178722.1 REFERENCE 1 (residues 1 to 265) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 265) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 265) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 265) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07487. Method: conceptual translation. FEATURES Location/Qualifiers source 1..265 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..265 /product="amphiphysin-like protein RVS161" /calculated_mol_wt="30119" Region 18..243 /region_name="BAR_Rvs161p" /note="The Bin/Amphiphysin/Rvs (BAR) domain of Saccharomyces cerevisiae Reduced viability upon starvation protein 161 and similar proteins; cd07591" /db_xref="CDD:153275" Site order(36,39..40,44,46..47,50..51,53..54,64..65,67..68, 71..72,74..75,78,94,97..98,191,194..195,197,202,205..206, 208..209,212..213,216..217,219..220,223..224,226..227) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153275" CDS 1..265 /gene="RVS161" /locus_tag="YCR009C" /gene_synonym="END6; FUS7; SPE161" /coded_by="NM_001178722.1:1..798" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005937 mating projection [PMID:9566960]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20610658|PMID:27093085]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:16239147]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:12477802]" /experiment="EXISTENCE:direct assay:GO:0060988 lipid tube assembly [PMID:20610658]" /experiment="EXISTENCE:direct assay:GO:0097320 plasma membrane tubulation [PMID:27093085]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:11096097]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8590801]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:1776363]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:7891662]" /experiment="EXISTENCE:mutant phenotype:GO:0042594 response to starvation [PMID:1776363]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:8590801]" /experiment="EXISTENCE:physical interaction:GO:0008092 cytoskeletal protein binding [PMID:10388809]" /experiment="EXISTENCE:physical interaction:GO:1990528 Rvs161p-Rvs167p complex [PMID:20610658]" /note="Amphiphysin-like lipid raft protein; N-BAR domain protein that interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress" /db_xref="GeneID:850367" /db_xref="SGD:S000000602" ORIGIN 1 mswegfkkai nraghsviik nvdktidkey dmeerrykvl qragealqke akgfldslra 61 vtasqttiae visnlyddsk yvagggynvg nyylqcvqdf dsetvkqldg plretvldpi 121 tkfstyfkei eeaikkrdhk kqdfdaakak vrrlvdkpak dasklpraek elslakdife 181 nlnnqlktel pqlvslrvpy fdpsfealik iqlrfctdgy trlaqiqqyl dqqsrddyan 241 glldtkieel lgqmtsldic algik // LOCUS NP_009936 283 aa linear PLN 30-JUN-2025 DEFINITION Ady2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009936 VERSION NP_009936.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178723.1 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 283) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07488. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..283 /product="Ady2p" /calculated_mol_wt="30595" Region 71..276 /region_name="Gpr1_Fun34_YaaH" /note="GPR1/FUN34/yaaH family; pfam01184" /db_xref="CDD:426106" CDS 1..283 /gene="ADY2" /locus_tag="YCR010C" /gene_synonym="ATO1" /coded_by="NM_001178723.1:1..852" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:17395151]" /experiment="EXISTENCE:mutant phenotype:GO:0006846 acetate transport [PMID:14968426]" /experiment="EXISTENCE:mutant phenotype:GO:0008519 ammonium channel activity [PMID:12429834]" /experiment="EXISTENCE:mutant phenotype:GO:0015123 acetate transmembrane transporter activity [PMID:14968426]" /experiment="EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:12429834]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:14968426]" /experiment="EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:12429834]" /note="Acetate transporter required for normal sporulation; phosphorylated in mitochondria; ADY2 has a paralog, ATO2, that arose from the whole genome duplication" /db_xref="GeneID:850368" /db_xref="SGD:S000000603" ORIGIN 1 msdkeqtsgn tdlenapagy ysshdndvng vaederpshd slgkiytggd nneyiyigrq 61 kflksdlyqa fggtlnpgla papvhkfanp aplglsafal ttfvlsmfna raqgitvpnv 121 vvgcamfygg lvqliagiwe ialentfggt alcsyggfwl sfaaiyipwf gileayedne 181 sdlnnalgfy llgwaiftfg ltvctmkstv mffllfflla ltflllsigh fanrlgvtra 241 ggvlgvvvaf iawynayagv atkqnsyvla rpfplpster vif // LOCUS NP_009937 1049 aa linear PLN 30-JUN-2025 DEFINITION putative ATP-dependent permease ADP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009937 VERSION NP_009937.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178724.1 REFERENCE 1 (residues 1 to 1049) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1049) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1049) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1049) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1049) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1049) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1049) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1049) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1049) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07489. On Sep 29, 2000 this sequence version replaced NP_009937.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1049 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1049 /product="putative ATP-dependent permease ADP1" /calculated_mol_wt="117101" Region <70..>90 /region_name="EGF_CA" /note="Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; cl21504" /db_xref="CDD:473889" Region 402..1042 /region_name="3a01204" /note="The Eye Pigment Precursor Transporter (EPP) Family protein; TIGR00955" /db_xref="CDD:273361" CDS 1..1049 /gene="ADP1" /locus_tag="YCR011C" /coded_by="NM_001178724.1:1..3150" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /note="Putative ATP-dependent permease of the ABC transporter family" /db_xref="GeneID:850369" /db_xref="SGD:S000000604" ORIGIN 1 mgshrrylyy silsflllsc svvlakqdkt pffegtsskn srltaqdkgn dtcppcfncm 61 lpifeckqfs ecnsytgrce ciegfagddc slplcgglsp desgnkdrpi raqndtchcd 121 ngwggincdv cqedfvcdaf mpdpsikgtc ykngmivdkv fsgcnvtnek ilqilngkip 181 qitfacdkpn qecnfqfwid qlesfycgls dcafeydleq ntshykcndv qckcvpdtvl 241 cgakgsidis dfltetikgp gdfscdletr qckfsepsmn dliltvfgdp yitlkcesge 301 cvhyseipgy kspskdptvs wqgklvlalt avmvlalftf atfyiskspl frnglgssks 361 pirlpdedav nnflqneddt latlsfenit ysvpsinsdg veetvlneis givkpgqila 421 imggsgagkt tlldilamkr ktghvsgsik vngismdrks fskiigfvdq ddfllptltv 481 fetvlnsall rlpkalsfea kkarvykvle elriidikdr iignefdrgi sggekrrvsi 541 acelvtsplv lfldeptsgl dasnannvie clvrlssdyn rtlvlsihqp rsnifylfdk 601 lvllskgemv ysgnakkvse flrnegyicp dnyniadyli ditfeagpqg krrrirnisd 661 leagtdtndi dntihqttft ssdgttqrew ahlaahrdei rsllrdeedv egtdgrrgat 721 eidlntkllh dkykdsvyya elsqeieevl segdeesnvl ngdlptgqqs agflqqlsil 781 nsrsfknmyr npklllgnyl ltillslflg tlyynvsndi sgfqnrmglf ffiltyfgfv 841 tftglssfal eriifikers nnyysplayy iskimsevvp lrvvppills livypmtgln 901 mkdnaffkci gililfnlgi sleiltigii fedlnnsiil svlvllgsll fsglfintkn 961 itnvafkylk nfsvfyyaye sllinevktl mlkerkygln ievpgatils tfgfvvqnlv 1021 fdikilalfn vvflimgyla lkwivveqk // LOCUS NP_009938 416 aa linear PLN 30-JUN-2025 DEFINITION phosphoglycerate kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009938 VERSION NP_009938.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178725.1 REFERENCE 1 (residues 1 to 416) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 416) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 416) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 416) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07490. On Sep 29, 2000 this sequence version replaced NP_009938.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..416 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..416 /product="phosphoglycerate kinase" /EC_number="2.7.2.3" /calculated_mol_wt="44607" Region 3..415 /region_name="Phosphoglycerate_kinase" /note="Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; cl00198" /db_xref="CDD:444741" Site order(24,26,39,63,122) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238195" Site order(199..202,390..392) /site_type="other" /note="hinge regions" /db_xref="CDD:238195" Site order(237,311,335,337,339..342,372..374) /site_type="other" /note="ADP binding site [chemical binding]" /db_xref="CDD:238195" Site 373 /site_type="active" /note="catalytic site [active]" /db_xref="CDD:238195" CDS 1..416 /gene="PGK1" /locus_tag="YCR012W" /coded_by="NM_001178725.1:1..1251" /experiment="EXISTENCE:direct assay:GO:0004618 phosphoglycerate kinase activity [PMID:6254992]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:27385335|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:400791]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:400791]" /note="3-phosphoglycerate kinase; catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis" /db_xref="GeneID:850370" /db_xref="SGD:S000000605" ORIGIN 1 mslssklsvq dldlkdkrvf irvdfnvpld gkkitsnqri vaalptikyv lehhpryvvl 61 ashlgrpnge rnekyslapv akelqsllgk dvtflndcvg peveaavkas apgsvillen 121 lryhieeegs rkvdgqkvka skedvqkfrh elssladvyi ndafgtahra hssmvgfdlp 181 qraagfllek elkyfgkale nptrpflail ggakvadkiq lidnlldkvd siiigggmaf 241 tfkkvlente igdsifdkag aeivpklmek akakgvevvl pvdfiiadaf sadantktvt 301 dkegipagwq gldngpesrk lfaatvakak tivwngppgv fefekfaagt kalldevvks 361 saagntviig ggdtatvakk ygvtdkishv stgggaslel legkelpgva flsekk // LOCUS NP_009940 582 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed DNA polymerase IV [Saccharomyces cerevisiae S288C]. ACCESSION NP_009940 VERSION NP_009940.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178727.1 REFERENCE 1 (residues 1 to 582) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 582) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 582) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 582) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07491. On Sep 29, 2000 this sequence version replaced NP_009940.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..582 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..582 /product="DNA-directed DNA polymerase IV" /EC_number="2.7.7.7" /calculated_mol_wt="67396" Region 188..574 /region_name="POLXc" /note="DNA polymerase X family; smart00483" /db_xref="CDD:214688" CDS 1..582 /gene="POL4" /locus_tag="YCR014C" /coded_by="NM_001178727.1:1..1749" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:8265341]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:8265341]" /experiment="EXISTENCE:direct assay:GO:0006302 double-strand break repair [PMID:12235149]" /experiment="EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15342630|PMID:10438542]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:10438542]" /note="DNA polymerase IV; undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta" /db_xref="GeneID:850372" /db_xref="SGD:S000000607" ORIGIN 1 mslkgkffaf lpnpntssnk ffksilekkg ativssiqnc lqssrkevvi liedsfvdsd 61 mhltqkdifq reaglndvde flgkieqsgi qcvktscitk wvqndkfafq kddlikfqps 121 iivisdnadd gqsstdkese istdvesern ddsnnkdmiq askplkrllq gdkgraslvt 181 dktkyknnel iigalkrltk kyeiegekfr arsyrlakqs mencdfnvrs geeahtklrn 241 igpsiakkiq vildtgvlpg lndsvgledk lkyfkncygi gseiakrwnl lnfesfcvaa 301 kkdpeefvsd wtilfgwsyy ddwlckmsrn ecfthlkkvq kalrgidpec qvelqgsynr 361 gyskcgdidl lffkpfcndt telakimetl ciklykdgyi hcflqltpnl eklflkrive 421 rfrtakivgy gerkrwysse iikkffmgvk lspreleelk emkndegtll ieeeeeeetk 481 lkpidqymsl nakdgnycrr ldffcckwde lgagrihytg skeynrwiri laaqkgfklt 541 qhglfrnnil lesfnerrif ellnlkyaep ehrniewekk ta // LOCUS NP_009941 317 aa linear PLN 30-JUN-2025 DEFINITION Cto1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009941 VERSION NP_009941.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178728.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 317) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07492. On Sep 29, 2000 this sequence version replaced NP_009941.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..317 /product="Cto1p" /calculated_mol_wt="36147" Region <128..237 /region_name="Haloacid Dehalogenase-like Hydrolases" /note="The haloacid dehalogenase (HAD) superfamily includes carbon and phosphorus hydrolases such as 2-haloalkonoate dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, among others. These...; cl21460" /db_xref="CDD:473868" CDS 1..317 /gene="CTO1" /locus_tag="YCR015C" /coded_by="NM_001178728.1:1..954" /experiment="EXISTENCE:direct assay:GO:0042131 thiamine phosphate phosphatase activity [PMID:26071590]" /experiment="EXISTENCE:mutant phenotype:GO:0006817 phosphate ion transport [PMID:25725023]" /note="Protein required for cold tolerance; involved in phosphate uptake; YCR015C is not an essential gene" /db_xref="GeneID:850373" /db_xref="SGD:S000000608" ORIGIN 1 mktiiisdfd etitrvdtic tiaklpylln prlkpewghf tktymdgyhk ykyngtrslp 61 llssgvptii sqsnfnklfa delkyqnhnr vvelnsvnei tkqqifksis ldqmktfard 121 qnhedcllrd gfktfcssvv knfesdfyvl sinwskefih evigdrrlkn shifcndlkk 181 vsdkcsqsyn gefdcrlltg sdkvkilgei ldkidsgcnk egnscsywyi gdsetdllsi 241 lhpstngvll inpqenpskf ikitekiigi pkdkissfea dngpawlqfc ekeggkgayl 301 vkswdslkdl imqvtkm // LOCUS NP_009942 290 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding ribosome assembly factor RBP95 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009942 VERSION NP_009942.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178729.1 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 290) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07493. On Sep 29, 2000 this sequence version replaced NP_009942.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..290 /product="RNA-binding ribosome assembly factor RBP95" /calculated_mol_wt="33462" Region 148..196 /region_name="WKF" /note="WKF domain; pfam10180" /db_xref="CDD:462982" CDS 1..290 /gene="RBP95" /locus_tag="YCR016W" /coded_by="NM_001178729.1:1..873" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:36018804]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:36018804|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:36018804]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:36018804]" /note="RNA-binding ribosome assembly factor; constituent of early pre-60S particles; genetically and physically linked to most NOP8 60s ribosome pre-assembly complex members and to ribosomal protein Rpl3p; contains two independent RNA-interacting domains; associates with helix H95 in 3' region of 25S rRNA, in close proximity to binding sites of Npa1p and Rpl3p; interacts with several snoRNAs" /db_xref="GeneID:850375" /db_xref="SGD:S000000609" ORIGIN 1 msenhvpawk rialkrqtis sgdeskekgq snlidddpln itthlstgnl tkkekkriin 61 gesksstkkg krvskpgtkk keklskdekn skknkilkdq lrylieffrt kseskfptgi 121 lelesvkeny gdslikdeps esgvvevwkf skqkqnwlik hffnldeips vyndllllyf 181 rdlqgkskee liskckgklk qwndyvedqe tkikaliaed kasepingee keegekdgna 241 eqgkqkevqd eqeevqmpnk elvqrslkll eiwknddseq ielknffvdv // LOCUS NP_009943 953 aa linear PLN 30-JUN-2025 DEFINITION Cwh43p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009943 VERSION NP_009943.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178730.1 REFERENCE 1 (residues 1 to 953) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 953) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 953) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 953) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07494. On Sep 29, 2000 this sequence version replaced NP_009943.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..953 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..953 /product="Cwh43p" /calculated_mol_wt="107752" Region 5..207 /region_name="Frag1" /note="Frag1/DRAM/Sfk1 family; pfam10277" /db_xref="CDD:431193" Region 686..911 /region_name="ElsH" /note="Metal-dependent hydrolase, endonuclease/exonuclease/phosphatase family [General function prediction only]; COG3568" /db_xref="CDD:442789" CDS 1..953 /gene="CWH43" /locus_tag="YCR017C" /coded_by="NM_001178730.1:1..2862" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11427965]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11427965]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11427965]" /experiment="EXISTENCE:mutant phenotype:GO:0006505 GPI anchor metabolic process [PMID:27462707]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:17714445|PMID:17761529]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:11427965]" /note="GPI lipid remodelase; responsible for introducing ceramides into GPI anchors having a C26:0 fatty acid in sn-2 of the glycerol moiety; can also use lyso-GPI protein anchors and various base resistant lipids as substrates; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion" /db_xref="GeneID:850376" /db_xref="SGD:S000000610" ORIGIN 1 mliingkiip iahticafsa ffaalvtgys lhfhkivtna hytypdewfp svsatigdry 61 persifqili altafprfll llghyylnqs kvcflvgvlr tvscggwvyi tstddhdihd 121 ifmityivlt lpwdimitry sspltsknkg ltatiffgtl fpmiywyiqh svqqragays 181 iyayfewsli lldiafdafa yadfkkidiv lafnekpgnt sffqirdssp inygeeksse 241 lqksgekkve kekpvarsat gsyfrfdsff ylltnifngf lfwsnvtsll csiwhfplwy 301 mgisgyeaai lgylgpifly lpfvseaftq ygvllggiia igayivqmpe lrlisvavgt 361 sitvatfvqn lryitnaets fsfaltwllg lvasvilkmg fytnnptwvi ldernggynk 421 talvltvlfg mlspyvnsin fegkrnaqak sasligklfl avgfgsllfg ihqlltdsst 481 tiywawegyn eshgplpwpw galtctvmlf aslssvkfmg kplvpcllll istavlsars 541 itqwpkyifg gllyaiamlw lvpsyfsalg qvqniwvyvl sfsvyiifvl ahvwvvayaf 601 vpmgwvlrek ietvlafsst fiiigaltck nlniqlvtmg kkffiyvfff avallsltar 661 fvydirptgi pqpyhpdsql itagiwtihf gldndmwase drminlikdm eldvvgllet 721 dtqritmgnr dltsklahdl nmyadfgpgp nkhtwgcvll skfpivnsth hllpspvgel 781 apaihatlqt yndtlvdvfv fhsgqeedee drrlqsnyma klmgnttrpa illsylvvdp 841 gegnyntyvs etsgmhdidp sdddrwceyi lyrglrrtgy arvargtitd telqvgkfqv 901 lseqalvehs dsmyeyghms epeyedmkfp dkflgegerg hfyhvfdepr yyl // LOCUS NP_009944 221 aa linear PLN 30-JUN-2025 DEFINITION Srd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009944 VERSION NP_009944.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178731.1 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 221) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07495. On Sep 29, 2000 this sequence version replaced NP_009944.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..221 /product="Srd1p" /calculated_mol_wt="25383" Region 163..214 /region_name="ZnF_GATA" /note="zinc finger binding to DNA consensus sequence [AT]GATA[AG]; smart00401" /db_xref="CDD:214648" CDS 1..221 /gene="SRD1" /locus_tag="YCR018C" /coded_by="NM_001178731.1:1..666" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:2179050]" /note="Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation" /db_xref="GeneID:850377" /db_xref="SGD:S000000611" ORIGIN 1 mrynnydnsg ssfltrvvkk sdmektllln reiddwksnd kkkaykergr vyascsfiev 61 sfsqiravdv ekkienaeql rdltrnivkn ktsslneitp sknrvtsacn serrttsqea 121 nnlegyhsca qgtsrsasit kkyskkttsr pkrekrqtil pngeikecsk ckdtwtiqwr 181 sgpdqnrelc spcglaygkr lkkenekkrq aadkridrnn p // LOCUS NP_009946 363 aa linear PLN 30-JUN-2025 DEFINITION Mak32p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009946 VERSION NP_009946.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178732.1 REFERENCE 1 (residues 1 to 363) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 363) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 363) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 363) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07496. Method: conceptual translation. FEATURES Location/Qualifiers source 1..363 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..363 /product="Mak32p" /calculated_mol_wt="40652" Region 13..344 /region_name="MAK32" /note="MAK32 kinase. MAK32 is a protein found primarily in fungi that is necessary for the structural stability of L-A particles. The L-A virus particule is a specialized compartment for the transcription and replication of double-stranded RNA, known to...; cd01943" /db_xref="CDD:238918" Site order(43,283,286) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238918" Site order(204,245,281,284..285,288,310,313) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238918" CDS 1..363 /gene="MAK32" /locus_tag="YCR019W" /coded_by="NM_001178732.1:1..1092" /note="Protein necessary for stability of L-A dsRNA-containing particles" /db_xref="GeneID:850381" /db_xref="SGD:S000000612" ORIGIN 1 mmneedstet kslvitngmf iiddiersky nihyknvpgg ggtfailgac iissgnvtsk 61 glkwivdrgs dfpkevirei dswgtdvrfr ddfsrlttkg lnyyegsddl rkfkfltpkk 121 qinvddwist fgqkiidemh afhllcsgsr cldiindllr vksskgtkpi viwepfpdlc 181 dfdhqndiks vmqrndvtvi lspnaeessr lfglsskept sleeclalah rfddfmdenn 241 mcilrcgalg sisvsekfkn grtydhfpay hfktqskvld ptgggnsflg gfavsyaltk 301 sldiasicgn iaagaiieqf giprydpiak twngitfldr lkfylsqsgl qynindlyks 361 ltr // LOCUS NP_009947 215 aa linear PLN 30-JUN-2025 DEFINITION Pet18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009947 VERSION NP_009947.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178733.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 215) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07497. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..215 /product="Pet18p" /calculated_mol_wt="25093" Region 4..213 /region_name="TenA_E_Spr0628-like" /note="TenA_E proteins similar to Streptococcus pneumoniae Spr0628 and Saccharomyces cerevisiae S288C PET18; cd19358" /db_xref="CDD:381693" CDS 1..215 /gene="PET18" /locus_tag="YCR020C" /gene_synonym="HIT2" /coded_by="NM_001178733.1:1..648" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16850348]" /experiment="EXISTENCE:expression pattern:GO:0006772 thiamine metabolic process [PMID:10383756]" /note="hypothetical protein; has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin" /db_xref="GeneID:850382" /db_xref="SGD:S000000613" ORIGIN 1 mscttdkliq kydalvrktt ehkfakelca gtlkdrslyi ylsqdlqffe tslrlicktt 61 slaptthali tlakkigffs ndensyfhdc lellapsltk eerdnfdnka ipgvdayinf 121 ldelrkdasi twpslvtslw vaeelywrwa rdtprapglh wkyqkwidlh dgehfqtwce 181 flkaevdkfp veevesifvk vsqfefeffe scyna // LOCUS NP_009948 88 aa linear PLN 30-JUN-2025 DEFINITION Mak31p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009948 VERSION NP_009948.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178734.1 REFERENCE 1 (residues 1 to 88) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 88) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 88) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 88) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07498. Method: conceptual translation. FEATURES Location/Qualifiers source 1..88 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..88 /product="Mak31p" /calculated_mol_wt="9593" Region 3..69 /region_name="LSMD1" /note="LSM domain containing 1; cd06168" /db_xref="CDD:212486" Site order(14..20,22..34,36..40) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212486" Site order(32,34,59) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:212486" Site 55..66 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212486" CDS 1..88 /gene="MAK31" /locus_tag="YCR020C-A" /gene_synonym="LSM9; NAA38; SMX1" /coded_by="NM_001178734.1:1..267" /experiment="EXISTENCE:direct assay:GO:0031417 NatC complex [PMID:10504710]" /experiment="EXISTENCE:mutant phenotype:GO:0004596 protein-N-terminal amino-acid acetyltransferase activity [PMID:11274203]" /experiment="EXISTENCE:mutant phenotype:GO:0006474 N-terminal protein amino acid acetylation [PMID:11274203]" /note="Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family" /db_xref="GeneID:850383" /db_xref="SGD:S000000614" ORIGIN 1 mdilklsdfi gntlivslte drilvgslva vdaqmnllld hveermgsss rmmglvsvpr 61 rsvktimidk pvlqeltank velmaniv // LOCUS NP_009949 78 aa linear PLN 30-JUN-2025 DEFINITION Htl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009949 VERSION NP_009949.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184313.1 REFERENCE 1 (residues 1 to 78) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 78) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 78) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 78) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07499. Method: conceptual translation. FEATURES Location/Qualifiers source 1..78 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..78 /product="Htl1p" /calculated_mol_wt="9048" CDS 1..78 /gene="HTL1" /locus_tag="YCR020W-B" /coded_by="NM_001184313.1:1..237" /experiment="EXISTENCE:curator inference:GO:0003682 chromatin binding [PMID:12417720]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:12417720]" /note="Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance" /db_xref="GeneID:850384" /db_xref="SGD:S000006439" ORIGIN 1 msqnntissm nperaynnvt lknltafqll sqrenicell nlvesterhn siinperqrm 61 sleemkkmld alknerkk // LOCUS NP_009950 332 aa linear PLN 30-JUN-2025 DEFINITION Hsp30p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009950 VERSION NP_009950.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178735.1 REFERENCE 1 (residues 1 to 332) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 332) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 332) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 332) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07500. Method: conceptual translation. FEATURES Location/Qualifiers source 1..332 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..332 /product="Hsp30p" /calculated_mol_wt="36914" Region 29..269 /region_name="7tm_YRO2_fungal-like" /note="fungal YRO2 and related proteins, member of the seven-transmembrane GPCR superfamily; cd15239" /db_xref="CDD:320367" Region 30..55 /region_name="TM helix 1" /note="TM helix 1 [structural motif]" /db_xref="CDD:320367" Region 65..87 /region_name="TM helix 2" /note="TM helix 2 [structural motif]" /db_xref="CDD:320367" Region 119..141 /region_name="TM helix 3" /note="TM helix 3 [structural motif]" /db_xref="CDD:320367" Site order(125,128..129,168,172,187,190..191,194,226,229..230, 233,255,258..259) /site_type="other" /note="putative ligand binding site [chemical binding]" /db_xref="CDD:320367" Region 156..176 /region_name="TM helix 4" /note="TM helix 4 [structural motif]" /db_xref="CDD:320367" Region 183..207 /region_name="TM helix 5" /note="TM helix 5 [structural motif]" /db_xref="CDD:320367" Region 209..236 /region_name="TM helix 6" /note="TM helix 6 [structural motif]" /db_xref="CDD:320367" Region 245..269 /region_name="TM helix 7" /note="TM helix 7 [structural motif]" /db_xref="CDD:320367" CDS 1..332 /gene="HSP30" /locus_tag="YCR021C" /gene_synonym="YRO1" /coded_by="NM_001178735.1:1..999" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:1535043]" /experiment="EXISTENCE:mutant phenotype:GO:0032780 negative regulation of ATP-dependent activity [PMID:9250391]" /note="Negative regulator of the H(+)-ATPase Pma1p; stress-responsive protein; hydrophobic plasma membrane localized; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase" /db_xref="GeneID:850385" /db_xref="SGD:S000000615" ORIGIN 1 mndtlssfln rnealglnpp hgldmhitkr gsdwlwavfa vfgfillcyv vmffiaenkg 61 srltryalap aflitffeff afftyasdlg wtgvqaefnh vkvsksitge vpgirqifys 121 kyiawflswp cllflielaa sttgenddis aldmvhslli qivgtlfwvv sllvgsliks 181 tykwgyytig avamlvtqgv icqrqffnlk trgfnalmlc tcmvivwlyf icwglsdggn 241 riqpdgeaif ygvldlcvfa iypcylliav srdgklprls ltggfshhha tddvedaape 301 tkeavpespr asgetaihep epeaeqaved ta // LOCUS NP_001335750 114 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR022C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335750 VERSION NP_001335750.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348895.1 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 114) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80270. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..114 /product="uncharacterized protein" /calculated_mol_wt="13045" CDS 1..114 /locus_tag="YCR022C" /coded_by="NM_001348895.1:1..345" /note="hypothetical protein; conserved among S. cerevisiae strains; YCR022C is not an essential gene" /db_xref="GeneID:850386" /db_xref="SGD:S000000616" ORIGIN 1 menrcsnpcy iqsdpsdlls lrlparfcwp fsrssrifqg ssrrrilseg knaskacfvr 61 ifgmakvska isrsrsrllf rslpphpacl feyqissssl fhhpfllwqg qvff // LOCUS NP_009952 611 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR023C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009952 VERSION NP_009952.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178737.1 REFERENCE 1 (residues 1 to 611) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 611) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 611) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 611) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07501. On Sep 29, 2000 this sequence version replaced NP_009952.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..611 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..611 /product="uncharacterized protein" /calculated_mol_wt="69087" Region 23..564 /region_name="MFS_SLC46_TetA_like" /note="Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; cd17330" /db_xref="CDD:340888" Site order(30..31,34..35,38,76,126..127,129..131,134,154, 157..158,161,361,364..365,368..370,373,423,427,488..489, 493,497,513,516..517,520..521,524) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340888" CDS 1..611 /locus_tag="YCR023C" /coded_by="NM_001178737.1:1..1836" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12562762]" /note="Vacuolar membrane hypothetical protein; homolog of human CLN7 which is an organellar chloride channel regulating lysosomal function; targeted to vacuole via AP-3 pathway; member of multidrug resistance family; not an essential gene" /db_xref="GeneID:850387" /db_xref="SGD:S000000617" ORIGIN 1 marqkltfke qmdgfpwvql vvvslvrfse piafsslfpy vyfmvrdfni apndaqvsky 61 sgylsssfal cqvisayhwg rfsekhgrki tltcgligts vsllilgfsr nfyqalvars 121 lmgllngnvg virtiigeia terkhqalaf stmpllfqfg avvgpmiggf lvfrdgtmne 181 vplwfphfak riirsypyal pnvvvcmflm fgltnatlfl eethpafkdr rdyglevgdf 241 ikknifgiqp krrpwqkriq ddsenihhrn envnsirgqd seedensplv nttndddtes 301 iqsidpiltr rqsvglirty slheptdavh anidtapdgc kessifhhvf htkvfypisv 361 nfimalhliv yneflpvfla ydlavdpenp kklaskfpwk isggigyepe qtgtllsttg 421 ifgcfvvifi fpivdrnfdc ltifrtlvkl ypimyvmvpy vvflqnerip swytvvylyi 481 itgiktfcga ltspqimlli hnssplscrs vingatisis asarfigplv wgyimswsqq 541 ndvawvswws lslfcmvaly qsykiapidd nenelhgqgs edaynsqsqs sdlrmahrss 601 lsslsnqrct t // LOCUS NP_009953 492 aa linear PLN 30-JUN-2025 DEFINITION asparagine--tRNA ligase SLM5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009953 VERSION NP_009953.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178738.1 REFERENCE 1 (residues 1 to 492) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 492) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 492) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 492) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07502. Method: conceptual translation. FEATURES Location/Qualifiers source 1..492 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..492 /product="asparagine--tRNA ligase SLM5" /EC_number="6.1.1.22" /calculated_mol_wt="56654" Region 16..492 /region_name="asnS" /note="asparaginyl-tRNA synthetase; TIGR00457" /db_xref="CDD:273086" CDS 1..492 /gene="SLM5" /locus_tag="YCR024C" /coded_by="NM_001178738.1:1..1479" /experiment="EXISTENCE:direct assay:GO:0004816 asparagine-tRNA ligase activity [PMID:9030748]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006421 asparaginyl-tRNA aminoacylation [PMID:9030748]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9030748]" /experiment="EXISTENCE:mutant phenotype:GO:0070145 mitochondrial asparaginyl-tRNA aminoacylation [PMID:9030748]" /note="Mitochondrial asparaginyl-tRNA synthetase" /db_xref="GeneID:850388" /db_xref="SGD:S000000618" ORIGIN 1 mfhaftflkg grfyssltvk slyeqvhhts hdpisingwi ksirllkria fldlqdgtsv 61 nplriviplt ntdevqflki lktgqtlsis natwqstpnr kqpfelqikn pvksiklvgp 121 vsenyplqkk yqtlrylrsl ptlkyrtayl sailrlrsfv efqfmlyfqk nhftkvsppi 181 ltsndcegag elfqvstnts ptassyfgkp tyltvstqlh leilalslsr cwtlspcfra 241 eksdtprhls efwmlevemc fvnsvnelts fvettikhii kacidnqqel lpkqfissqe 301 nnasselsin qetqqiktrw edlinekwhn itytnaieil kkrhnevshf kyepkwgqpl 361 qtehekflag eyfkspvfvt dyprlckpfy mkqnstpddt vgcfdllvpg mgeiiggslr 421 eddydklcre mkargmnrsg eldwyvslrk egsaphggfg lgferfisyl ygnhnikdai 481 pfyrtsaesi df // LOCUS NP_878057 88 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR024C-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878057 VERSION NP_878057.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184645.1 REFERENCE 1 (residues 1 to 88) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 88) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 88) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 88) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07503. Method: conceptual translation. FEATURES Location/Qualifiers source 1..88 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..88 /product="uncharacterized protein" /calculated_mol_wt="10481" CDS 1..88 /locus_tag="YCR024C-B" /coded_by="NM_001184645.1:1..267" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466398" /db_xref="SGD:S000028818" ORIGIN 1 mcvcaipffe fflpfiphya fllfvssvrf tvnercyylv cvlklncaff fmvmifelkr 61 vcvsyldrsr kiqivsffpf itiiffhs // LOCUS NP_058137 40 aa linear PLN 30-JUN-2025 DEFINITION proteolipid ATPase [Saccharomyces cerevisiae S288C]. ACCESSION NP_058137 VERSION NP_058137.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178739.1 REFERENCE 1 (residues 1 to 40) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 40) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 40) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 40) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07504. Method: conceptual translation. FEATURES Location/Qualifiers source 1..40 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..40 /product="proteolipid ATPase" /calculated_mol_wt="4369" Region 2..40 /region_name="PMP1_2" /note="ATPase proteolipid family; pfam08114" /db_xref="CDD:285351" CDS 1..40 /gene="PMP1" /locus_tag="YCR024C-A" /coded_by="NM_001178739.1:1..123" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:1532582]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:1532582]" /experiment="EXISTENCE:genetic interaction:GO:0005886 plasma membrane [PMID:8063750]" /experiment="EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:8063750]" /experiment="EXISTENCE:genetic interaction:GO:0032781 positive regulation of ATP-dependent activity [PMID:8063750]" /note="Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication" /db_xref="GeneID:850389" /db_xref="SGD:S000000619" ORIGIN 1 mtlpggvilv filvglacia iiatiiyrkw qarqrglqrf // LOCUS NP_001335751 136 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR025C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335751 VERSION NP_001335751.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348896.1 REFERENCE 1 (residues 1 to 136) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 136) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 136) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 136) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80271. Method: conceptual translation. FEATURES Location/Qualifiers source 1..136 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..136 /product="uncharacterized protein" /calculated_mol_wt="15933" CDS 1..136 /locus_tag="YCR025C" /coded_by="NM_001348896.1:1..411" /note="hypothetical protein; conserved across S. cerevisiae strains; YCR025C is not an essential gene" /db_xref="GeneID:850390" /db_xref="SGD:S000000620" ORIGIN 1 mssfghraff sccplleget lhsiklrkea tyqtqsgwpv rwpirypral pleshvhpyh 61 mivklphprt qprlflwlsl hwtgipflgk pgigrnrvks kqfshfqqsk ikttmrkktt 121 nrkqkaercq yrlvta // LOCUS NP_009955 742 aa linear PLN 30-JUN-2025 DEFINITION nucleotide diphosphatase/phosphodiesterase NPP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009955 VERSION NP_009955.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178741.1 REFERENCE 1 (residues 1 to 742) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 742) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 742) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 742) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07505. On Sep 29, 2000 this sequence version replaced NP_009955.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..742 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..742 /product="nucleotide diphosphatase/phosphodiesterase NPP1" /EC_number="3.1.4.1" /EC_number="3.6.1.9" /calculated_mol_wt="84603" Region 170..545 /region_name="Phosphodiest" /note="Type I phosphodiesterase / nucleotide pyrophosphatase; pfam01663" /db_xref="CDD:396300" Site order(176,218..219,240,362,366,415..416,542) /site_type="active" /db_xref="CDD:293742" Site order(176,218..219,240,362,366,416,542) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:293742" CDS 1..742 /gene="NPP1" /locus_tag="YCR026C" /coded_by="NM_001178741.1:1..2229" /experiment="EXISTENCE:direct assay:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]" /experiment="EXISTENCE:genetic interaction:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:16278456]" /experiment="EXISTENCE:genetic interaction:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0009141 nucleoside triphosphate metabolic process [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0016036 cellular response to phosphate starvation [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]" /note="Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; NPP1 has a paralog, NPP2, that arose from the whole genome duplication, and an npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants" /db_xref="GeneID:850391" /db_xref="SGD:S000000621" ORIGIN 1 melqndlesl dnelndfsed pfrddfitde davrsgwrsa wtrmkywfyk nrlkwtnnpi 61 vigdakdsrd gsnfrrgipl yeldangqpi dtelvdenel sfgtgfhskv pfkiifrtlf 121 gslvfaifli lminiakphh strvlshfgs pefdpyvkyf ngtheffplt ivisldgfhp 181 sliskrntpf lhdlyelkyd ggmnitstpf mvpsfptetf pnhwtlvtgq ypihhgivsn 241 vfwdpdlnee fhpgvldpri wnnndtepiw qtvqsafdgd ipfkaathmw pgsdvnytky 301 neeklqpehk npiarertpf yfdefnakep lsqklskiie yvdmstlner pqlilgyvpn 361 vdafghkhgy pseseyyyed ftetlgevdt flkqlveslq ernltsftnl vivsdhgmsd 421 ivvpsnviiw edlldeklrk dyvshayleg pmmaislkds gninevyhnl ktsidedkyt 481 vyvngnfpke wnfndgknhh masiwivpep gyavmkkeql kkvakgdhkd knednvftig 541 shgydnnaid mrsvfigmgp yfpqgyiepf qnteiynllc dicgvaekdr nsndgtgmlm 601 nqlrepqsse eveieddfdy lvskfgefst yniiwggype eteqdnvdnd nddnddgntd 661 eiaampsssl tiklemttsi psatetllge tspssrssss ssiqasatas tvgdwlqdii 721 ndakdliddi idsiddlvds dt // LOCUS NP_009956 209 aa linear PLN 30-JUN-2025 DEFINITION putative GTPase RHB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009956 VERSION NP_009956.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178742.1 REFERENCE 1 (residues 1 to 209) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 209) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 209) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 209) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07506. On Sep 29, 2000 this sequence version replaced NP_009956.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..209 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..209 /product="putative GTPase RHB1" /calculated_mol_wt="23207" Region 16..209 /region_name="RheB" /note="Ras Homolog Enriched in Brain (RheB) is a small GTPase; cd04137" /db_xref="CDD:206709" Site 23..30 /site_type="other" /note="G1 box" /db_xref="CDD:206709" Site order(24..25,72..73) /site_type="other" /note="putative GDI interaction site [polypeptide binding]" /db_xref="CDD:206709" Site order(25..31,41..42,45,48,73,129..130,132..133,171..172) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206709" Site order(30..31,45,47,53..54,67..68,70,72..73,173) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206709" Site order(46..47,51..54) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206709" Site 46..53 /site_type="other" /note="Switch I region" /db_xref="CDD:206709" Site 48 /site_type="other" /note="G2 box" /db_xref="CDD:206709" Site 70..73 /site_type="other" /note="G3 box" /db_xref="CDD:206709" Site 72..90 /site_type="other" /note="Switch II region" /db_xref="CDD:206709" Site 129..132 /site_type="other" /note="G4 box" /db_xref="CDD:206709" Site 171..173 /site_type="other" /note="G5 box" /db_xref="CDD:206709" Site 206..209 /site_type="other" /note="putative lipid modification site [posttranslational modification]" /db_xref="CDD:206709" CDS 1..209 /gene="RHB1" /locus_tag="YCR027C" /gene_synonym="RSG1" /coded_by="NM_001178742.1:1..630" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:17101785]" /note="Putative Rheb-related GTPase; involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins" /db_xref="GeneID:850392" /db_xref="SGD:S000000622" ORIGIN 1 meyatmsssn sthnfqrkia ligarnvgkt tltvrfvesr fvesyyptie neftriipyk 61 shdctleild tagqdevsll niksltgvrg iilcysiinr asfdlipilw dklvdqlgkd 121 nlpvilvgtk adlgrstkgv krcvtkaege klastigsqd krnqaafiec saeldynvee 181 tfmlllkqme rvegtlglda ennnkcsim // LOCUS NP_009957 512 aa linear PLN 30-JUN-2025 DEFINITION Fen2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009957 VERSION NP_009957.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178743.1 REFERENCE 1 (residues 1 to 512) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 512) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 512) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 512) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07507. Method: conceptual translation. FEATURES Location/Qualifiers source 1..512 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..512 /product="Fen2p" /calculated_mol_wt="58126" Region 32..450 /region_name="MFS_FEN2_like" /note="Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; cd17327" /db_xref="CDD:340885" Site order(48..49,52..53,56,89,139..140,142..144,147,167, 170..171,174,281,284..285,288..290,293,321,325,377..378, 382,386,404,407..408,411..412,415) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340885" CDS 1..512 /gene="FEN2" /locus_tag="YCR028C" /coded_by="NM_001178743.1:1..1539" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:10373490]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:15020461]" /experiment="EXISTENCE:mutant phenotype:GO:0015233 pantothenate transmembrane transporter activity [PMID:10373490]" /experiment="EXISTENCE:mutant phenotype:GO:0015887 pantothenate transmembrane transport [PMID:10373490]" /note="Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph; relocalizes from vacuole to cytoplasm upon DNA replication stress" /db_xref="GeneID:850394" /db_xref="SGD:S000000623" ORIGIN 1 mmkesksitq heveresvss kraikkrlll fkidlfvlsf vclqywinyv drvgftnayi 61 sgmkedlkmv gndltvsntv fmigyivgmv pnnlmllcvp priwlsfctf awglltlgmy 121 kvtsfkhica irffqalfes ctfsgthfvl gswykedelp irsaiftgsg lvgsmfsgfm 181 qtsifthlng rnglagwrwl fiidfcitlp iaiygfiffp glpdqtsavs kfsmtryifn 241 eqelhyarrr lpardestrl dwstiprvlk rwhwwmfslv wvlggenlgf asnstfalwl 301 qnqkytlaqr nnypsgifav givstlcsav ymskiprarh whvsvfislv mvivavlira 361 dplnpkvvfs aqylggvaya gqavffswan iichadlqer aivlasmnmf sgavnawwsi 421 lffasdmvpk fergcyalla taissgivsv virslqiken lskkqvpyid andmpgeddd 481 ddnqdnendg ddesmevelh neemaeisnp fr // LOCUS NP_009958 135 aa linear PLN 30-JUN-2025 DEFINITION Rim1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009958 VERSION NP_009958.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184315.1 REFERENCE 1 (residues 1 to 135) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 135) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 135) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 135) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07508. On Sep 29, 2000 this sequence version replaced NP_009958.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..135 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..135 /product="Rim1p" /calculated_mol_wt="15255" Region 19..116 /region_name="SSB" /note="Single-strand binding protein family; pfam00436" /db_xref="CDD:425680" Site order(22..25,50..52,59,61,83,92,103,106) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:239942" Site order(27..29,35,45,52..53,57..58,60,62,64,66,80..81,89,91, 93..94,107,109) /site_type="other" /note="ssDNA binding site [nucleotide binding]" /db_xref="CDD:239942" Site order(83,85,87,114) /site_type="other" /note="tetramer (dimer of dimers) interface [polypeptide binding]" /db_xref="CDD:239942" CDS 1..135 /gene="RIM1" /locus_tag="YCR028C-A" /coded_by="NM_001184315.1:1..408" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:1324172]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14576278|PMID:1324172]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10869431]" /experiment="EXISTENCE:direct assay:GO:0090297 positive regulation of mitochondrial DNA replication [PMID:26184436]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:1324172]" /note="ssDNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication; stimulates utilization by Mip1p DNA polymerase of RNA primers synthesized by Rpo41p" /db_xref="GeneID:850395" /db_xref="SGD:S000007222" ORIGIN 1 mflrtqarff hattkkmdfs kmsivgrigs eftehtsann nrylkysias qprrdgqtnw 61 ynitvfnepq inflteyvrk galvyveada anyvferddg skgttlslvq kdinllkngk 121 kledaegqen aasse // LOCUS NP_009959 870 aa linear PLN 30-JUN-2025 DEFINITION Syp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009959 VERSION NP_009959.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178744.1 REFERENCE 1 (residues 1 to 870) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 870) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 870) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 870) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 870) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 870) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 870) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 870) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 870) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07509. On Sep 29, 2000 this sequence version replaced NP_009959.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..870 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..870 /product="Syp1p" /calculated_mol_wt="96007" Region 16..250 /region_name="F-BAR_Syp1p_like" /note="The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of yeast Syp1 protein; cd07650" /db_xref="CDD:153334" Site order(32,35,42,45..46,49,52..53,56..57,60,64,67,71,97,100, 170,174,200,204,207,210..211,214,218,221,225,229,232..233, 236) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153334" Site order(33,37,44,58..59,69,131) /site_type="active" /note="putative membrane interaction surface [active]" /db_xref="CDD:153334" Region 251..>530 /region_name="PHA03307" /note="transcriptional regulator ICP4; Provisional" /db_xref="CDD:223039" Region <393..>580 /region_name="Atrophin-1" /note="Atrophin-1 family; pfam03154" /db_xref="CDD:460830" Region 610..867 /region_name="muHD" /note="Muniscin C-terminal mu homology domain; pfam10291" /db_xref="CDD:463046" CDS 1..870 /gene="SYP1" /locus_tag="YCR030C" /gene_synonym="YCR029C-A" /coded_by="NM_001178744.1:1..2613" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:26179915]" /experiment="EXISTENCE:direct assay:GO:0001400 mating projection base [PMID:11014808]" /experiment="EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:19962315]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11014808]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11014808]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0061645 endocytic patch [PMID:19962315]" /experiment="EXISTENCE:genetic interaction:GO:0032185 septin cytoskeleton organization [PMID:18791237]" /experiment="EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:19776351]" /experiment="EXISTENCE:mutant phenotype:GO:0032185 septin cytoskeleton organization [PMID:18791237]" /experiment="EXISTENCE:physical interaction:GO:0032185 septin cytoskeleton organization [PMID:18791237]" /note="Inhibitor of Las17p-mediated Arp2/3 complex activation; F-BAR protein that directly inhibits Las17p stimulation of Arp2/3 complex-mediated actin assembly in vitro; involved in formation of the endocytic site; intrinsically disordered domain induces bundling of Cdc11p-capped septin filaments to promote septin collar assembly, similar to mammalian ortholog FCHo2; localizes to sites of polarized growth, the septin ring, and endocytic patches; involved in actin cytoskeletal organization" /db_xref="GeneID:850396" /db_xref="SGD:S000000626" ORIGIN 1 mteqrtkyad silttkspye atetirirls qvkllnkdfy llfkelanlk rnyaqqlrki 61 iaeneditki lnaqmiesnv ltpqemsafr fnslgelrnv wdtvieelks dlkssteyyn 121 tldqqvvrel kesvenntsw reskdlhskl sknaasiehy sknnensshl eearrqwdqq 181 spylfelfet idynrldtlk ncmlrfqtsf sdyllnttke cetvmtkfla fepqseidrf 241 akdasqynfq lsssskevvp nnaspasatg arpvsvsnga anterekksp qkdkrksafg 301 nighrlasas sslthndlmn nefsdstnns slkskkssht lrskvgsifg rnktknkrqq 361 qsssnshiqa sitetpnnss trvsstatss iyqkqrrpty sssksnnwtp geasdtpplp 421 phatpknvda pvtadtppaq tftpsevpps tpqqssppta kepdssnlpk tvpisisqpp 481 lqpqsktkpl pvepaspsis lptatvdnqp sgqvdsrplh irapalppsr kqnfihnrds 541 qlydslpnhg sgatptsssl ssipqerpvs tlssqitgel relnpqatgs stslvgqslf 601 qhssldtsqf glnasiaevl nasfkdgmlq nsqligeial nylpnsvmns plpiginlri 661 nngakfekvi lnqafierva peefkvnpsf idsrtlgaik ysikepiapi vihpvwrfes 721 hqasvvltvk mspslpdeis qiviedlvvf vnidganats alskpqgsfs kekkritwrf 781 kepvvltrng egqrliarfi tdglahesak gvitkftise tdnvalphsg agsgitltcq 841 eldennpfgg ewldvntkrt lttgnyhgla // LOCUS NP_009960 137 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS11 RPS14A [Saccharomyces cerevisiae S288C]. ACCESSION NP_009960 VERSION NP_009960.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178745.1 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 137) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07510. On Sep 29, 2000 this sequence version replaced NP_009960.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..137 /product="40S ribosomal protein uS11 RPS14A" /calculated_mol_wt="14405" Region 6..126 /region_name="PTZ00129" /note="40S ribosomal protein S14; Provisional" /db_xref="CDD:185465" CDS 1..137 /gene="RPS14A" /locus_tag="YCR031C" /gene_synonym="CRY1; RPL59" /coded_by="NM_001178745.1:1..414" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:9858605]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:8293976|PMID:2277060]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15125836]" /note="Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14A has a paralog, RPS14B, that arose from the whole genome duplication" /db_xref="GeneID:850397" /db_xref="SGD:S000000627" ORIGIN 1 msnvvqardn sqvfgvariy asfndtfvhv tdlsgketia rvtggmkvka drdesspyaa 61 mlaaqdvaak ckevgitavh vkiratggtr tktpgpggqa alralarsgl rigriedvtp 121 vpsdstrkkg grrgrrl // LOCUS NP_009961 2167 aa linear PLN 30-JUN-2025 DEFINITION Bph1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009961 VERSION NP_009961.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178746.1 REFERENCE 1 (residues 1 to 2167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2167) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 2167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 2167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 2167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07511. On Sep 29, 2000 this sequence version replaced NP_009961.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..2167 /product="Bph1p" /calculated_mol_wt="250742" Region 1371..1500 /region_name="PH_BEACH" /note="Pleckstrin homology domain in BEACH domain containing proteins; cd01201" /db_xref="CDD:275391" Region 1558..1839 /region_name="Beach" /note="Beige/BEACH domain; smart01026" /db_xref="CDD:214982" Region 1933..1976 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1981..2017 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 2021..2055 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..2167 /gene="BPH1" /locus_tag="YCR032W" /coded_by="NM_001178746.1:1..6504" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:35343566]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15296494]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:35343566]" /experiment="EXISTENCE:mutant phenotype:GO:0006497 protein lipidation [PMID:35343566]" /experiment="EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:15296494]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:35343566]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:35343566]" /experiment="EXISTENCE:mutant phenotype:GO:0009268 response to pH [PMID:9509574]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:15296494]" /note="Endosomal protein involved in endocytosis and autophagy; homologous to Chediak-Higashi syndrome and Beige proteins, both of which are implicated in disease syndromes in human and mouse, respectively, due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting" /db_xref="GeneID:850398" /db_xref="SGD:S000000628" ORIGIN 1 mnsiinaask vlrlqddvkk atiilgdili lqpinhevep dvenlvqhel tkiiqgypiq 61 dnmiinskkg tveddlceln nytcfalsks fdlchdsrnf niaqpkrwiq lletltdsvs 121 favivqiilt lsnislinkq tlgklkklri rifeilsnkn dswkstllqk nliewyifml 181 svdctplelq nlylhkelkf cngilnsltl qvsdprsqny lqfentyklf qiqkssrinn 241 sflfyiefns vtsnrimtie rhiyleikeg qfcisndnyi iglfenfefe agtlyfigvl 301 idhnnritly vdgsminqlt lfensicqls tcelgsmics ikvyrfylwd glltefaini 361 lqaigtnyqy tfskkkegpe vlslcqdfli akahlmarpt teisstkyid eiellemeni 421 iidvnpndil qdftessnft vkfeestnsk nipevgkcyf yrssnlvskf vsidsirlaf 481 lnmtesgsid dlfhhvshlm nllrnidiln wfkkdfgfpl faytlkqkit qdlsqplniq 541 ffnlflefcg wdfndisksi ildtdayeni vlnldlwymn edqsslasgg leiirflffq 601 isslmeasiy skfnsnkfnd mnileklcls yqavtkrenq nskfnelssd lisvfvtllk 661 sntdkrhlqw flhlsyyfik rkdvrsteii lqavdqlfsf yldqgsdena kilseiiplk 721 lilmimdqiv ennesnpitc lnilfkvvlt nkplfkqfyk ndglkliltm lckvgksyre 781 eiisllltys ignyttanei fsgaedmigg isndkitake iiylavnfie whvinsnasd 841 sssvldlnnh ilrfvedlks lsavpinesv fdpkksyvmv slldlsialn esediskfks 901 sskviselik gnimcaltky aaydfevyms tffchsteyk lvypktvmnn ssylelsfiv 961 tllpeilndl vdsnnnlnlm mlkhpytmsn llyflrkfrp dtsqivmpkd fyfssytcll 1021 hcviqidkss fyhfknvsks qllqdfkici mnliysntlk qiiwekeeye mfseslmahq 1081 evlfahgacd netvglllif fanrlrdcgy nkavfncmkv iiknkerklk evacffdpan 1141 ksevleglsn ilscnnsetm nliteqypff fnntqqvrfi nivtnilfkn nnfspisvrq 1201 iknqvyewkn arseyvtqnn kkclilfrkd ntsldfkikk sisrytynlk tdreenavfy 1261 rnnlnllifh lkhtleiqsn pnssckwssd faedfdgmkr rllpawepky eplineedan 1321 qdtitggnrq rresgsilsy efiehmetle sepvgdlnen rkilrllkdn dsiatiwncs 1381 liigleikeg ilihgsnyly fvsdyyfsle dkkilklsev sqesrdmtvs lingpdvkrv 1441 stflkhevfv wkllditfvt krpfllrdva iellfkervs affsfynkrv rddvlrvlnk 1501 ipkhlpadpi fssvlqeind rgnsivarng igkasiaskf tsvfsannsl idgfeiskkw 1561 vrgeisnfyy llsinilagr sfndltqypv fpwviadyes nvldlenpkt yrdlskpmga 1621 qsekrklqfi eryealasle nadsapfhyg thyssamivs sylirlkpfv esflllqggs 1681 fgpadrlfss lerawssass enttdvrelt peffflpefl invnsydfgt dqsgkkvddv 1741 vlppwangdp kvfiqknrea lespyvsahl hewidlifgy kqkgdiavks vnvfnrlsyp 1801 gavnldnidd enerraitgi ihnfgqtplq ifqephpeki acnvqqltte vwrkvpmkpi 1861 fektifnlne knrsvdyvih dpsyfdslyw rgfafpnlff rteeslvslr ivhknwlkig 1921 ldifkkthma qitsfaywkl gefitgdkng likvwkyrkd khsvsgnlen kktmfghlce 1981 lkemrcyhdy ntlltldisg lvyvwdminf elvrqitnda qkvaisqhag simvltknna 2041 isifnlngqi ytskkfepak ivssidffdf tkldagyrkh iywkemeill vgfedgtiei 2101 yelflnfhne waikllkqlc tekgkaitsi kgqgktylsq krrkdtaeph eieviagtld 2161 grlaiwy // LOCUS NP_009962 1226 aa linear PLN 30-JUN-2025 DEFINITION Snt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009962 VERSION NP_009962.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178747.1 REFERENCE 1 (residues 1 to 1226) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1226) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1226) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07512. On Sep 29, 2000 this sequence version replaced NP_009962.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1226 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1226 /product="Snt1p" /calculated_mol_wt="138267" Region 62..>173 /region_name="PHA03255" /note="BDLF3; Provisional" /db_xref="CDD:165513" Region 287..>587 /region_name="Mitofilin" /note="Mitochondrial inner membrane protein; pfam09731" /db_xref="CDD:430783" Region 672..716 /region_name="SANT" /note="'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is...; cd00167" /db_xref="CDD:238096" Site order(673,703..704,706..707,709..711,713..715) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238096" Region <715..803 /region_name="RPN2" /note="26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]; COG5116" /db_xref="CDD:227446" Region 892..933 /region_name="Myb_DNA-binding" /note="Myb-like DNA-binding domain; pfam00249" /db_xref="CDD:459731" CDS 1..1226 /gene="SNT1" /locus_tag="YCR033W" /coded_by="NM_001178747.1:1..3681" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0034967 Set3 complex [PMID:11711434]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:19379692]" /experiment="EXISTENCE:mutant phenotype:GO:0032874 positive regulation of stress-activated MAPK cascade [PMID:18487345]" /note="Set3C histone deacetylase scaffold; can act as prion [ESI+] (Expressed Subtelomeric Information) that drives emergence and transgenerational inheritance of activated chromatin state; prion conformer is triggered by transient Snt1p phosphorylation upon cell cycle arrest; [ESI+] reshapes the activity Set3C, recruiting RNAPII, interfering with Rap1p binding to activate genes in otherwise repressed subtelomeric domains; relocalizes to cytosol in response to hypoxia" /db_xref="GeneID:850399" /db_xref="SGD:S000000629" ORIGIN 1 mgyppptrrl gdkkryhysn npnrrhpsav ysknsfpkss nngfvsspta dnstnpsvtp 61 stasvplpta apgstfgiea prpsrydpss vsrpssssys strkigsryn pdverssstt 121 sstpesmnts tithtntdig nsrysrktms rynpqstsst nvthfpsals nappfyvang 181 ssrrprsmdd yspdvtnkle tnnvssvnnn sphsyysrsn kwrsigtpsr ppfdnhvgnm 241 tttsntnsih qrepfwkans ttilksthsq sspslhtkkf hdankldkpe asvkvetpsk 301 detkaisyhd nnfpprksvs kpnaplepdn ikvgeedalg kkevhksgre iakehptpvk 361 mkehdelear akkvskinid gkqdeiwtta ktvasavevs kesqkeltrs verkespeir 421 dyeraydpka lktdvtkltv dndnksyeep lekvegcifp lpkaetrlwe lknqkrnkii 481 seqkyllkka irnfseypfy aqnklihqqa tgliltkiis kikkeehlkk inlkhdyfdl 541 qkkyekecei ltklsenlrk eeienkrkeh elmeqkrree gietekeksl rhpssssssr 601 rrnradfvdd aemenvllqi dpnykhyqaa atipplildp irkhsykfcd vnnlvtdkkl 661 wasrilkdas dnftdhehsl flegylihpk kfgkishymg glrspeecvl hyyrtkktvn 721 ykqllidknk krkmsaaakr rkrkersnde evevdeskee stntiekeek sennaeenvq 781 pvlvqgsevk gdplgtpekv enmieqrgee fagelenaer vndlkrahde vgeesnkssv 841 ietnngvqim dpkgavqngy ypeetkeldf slenalqrkk hksapehkts ywsvresqlf 901 pellkefgsq wsliseklgt ksttmvrnyy qrnaarngwk llvdetdlkr dgtssesvqq 961 sqiliqperp ninaysnipp qqrpalgyfv gqpthghnts issidgsirp fgpdfhrdtf 1021 skisaplttl ppprlpsiqf prsemaeptv tdlrnrpldh idtladaass vtnnqnfsne 1081 rnaidigrks ttisnllnns drsmkssfqs asrheaqled tpsmnnivvq eikpnittpr 1141 sssisallnp vngngqsnpd grpllpfqha isqgtptfpl paprtspisr appkfnfsnd 1201 plaalaavas apdamssfls kkennn // LOCUS NP_009963 347 aa linear PLN 30-JUN-2025 DEFINITION fatty acid elongase ELO2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009963 VERSION NP_009963.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178748.1 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 347) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07513. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..347 /product="fatty acid elongase ELO2" /EC_number="2.3.1.199" /calculated_mol_wt="39871" Region 63..307 /region_name="ELO" /note="GNS1/SUR4 family; pfam01151" /db_xref="CDD:460083" CDS 1..347 /gene="ELO2" /locus_tag="YCR034W" /gene_synonym="FEN1; GNS1; VBM2" /coded_by="NM_001178748.1:1..1044" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12087109]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:23325927]" /experiment="EXISTENCE:mutant phenotype:GO:0009922 fatty acid elongase activity [PMID:12684876]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:9832547]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:9211877]" /experiment="EXISTENCE:mutant phenotype:GO:0030497 fatty acid elongation [PMID:9211877]" /experiment="EXISTENCE:mutant phenotype:GO:0042761 very long-chain fatty acid biosynthetic process [PMID:23325927]" /note="Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway; ELO2 has a paralog, ELO1, that arose from the whole genome duplication; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7" /db_xref="GeneID:850400" /db_xref="SGD:S000000630" ORIGIN 1 mnslvtqyaa plferypqlh dylptlerpf fnislwehfd dvvtrvtngr fvpsefqfia 61 gelplstlpp vlyaitayyv iifggrflls kskpfklngl fqlhnlvlts lsltllllmv 121 eqlvpiivqh glyfaicnig awtqplvtly ymnyivkfie fidtfflvlk hkkltflhty 181 hhgatallcy tqlmgttsis wvpislnlgv hvvmywyyfl aargirvwwk ewvtrfqiiq 241 fvldigfiyf avyqkavhly fpilphcgdc vgsttatfag caiissylvl fisfyinvyk 301 rkgtktsrvv krahggvaak vneyvnvdlk nvptpspspk pqhrrkr // LOCUS NP_009964 394 aa linear PLN 30-JUN-2025 DEFINITION exosome non-catalytic core subunit RRP43 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009964 VERSION NP_009964.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178749.1 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 394) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07514. On Sep 29, 2000 this sequence version replaced NP_009964.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..394 /product="exosome non-catalytic core subunit RRP43" /calculated_mol_wt="43880" Region 49..388 /region_name="RNase_PH" /note="RNase PH-like 3'-5' exoribonucleases; cd11358" /db_xref="CDD:206766" Site order(73,75,90,92..94,131,133,138,150,153,157,211,216,221, 239..241,290,356..368,374,378) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:206766" Site order(129..131,153,160) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:206766" CDS 1..394 /gene="RRP43" /locus_tag="YCR035C" /coded_by="NM_001178749.1:1..1185" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:19046973|PMID:10465791]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:9891085]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9891085]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9891085]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15828860|PMID:17643380]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12364597|PMID:10508172|PMID:9390555]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:12364597]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:27385342]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:18940861]" /experiment="EXISTENCE:mutant phenotype:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:19369424]" /note="Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850401" /db_xref="SGD:S000000631" ORIGIN 1 maesttleti eihpitfppe vlarispels lqrhlslgir pclrkyeefr dvaienntls 61 ryadagnidt knnilgsnvl ksgktivits itggiieets aaikdlddfg eeelfevtke 121 ediianyasv ypvvevergr vgactdeemt isqklhdsil hsrilpkkal kvkagvrsan 181 edgtfsvlyp deleddtlne tnlkmkrkws yvlyakivvl srtgpvfdlc wnslmyalqs 241 vklprafide rasdlrmtir trgrsatire tyeiicdqtk svplminakn iafasnygiv 301 eldpecqlqn sdnseeeevd idmdklntvl iadldteaee tsihstisil aapsgnykql 361 tlvgggakit pemikrslll srvraddlst rfni // LOCUS NP_009965 333 aa linear PLN 30-JUN-2025 DEFINITION putative ribokinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009965 VERSION NP_009965.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178750.1 REFERENCE 1 (residues 1 to 333) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 333) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 333) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 333) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07515. On Sep 29, 2000 this sequence version replaced NP_009965.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..333 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..333 /product="putative ribokinase" /EC_number="2.7.1.15" /calculated_mol_wt="36793" Region 2..324 /region_name="ribokinase" /note="Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; cd01174" /db_xref="CDD:238579" Site order(10,12,37..39,42,99,101,113,115,149,279..280,283,319) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238579" Site order(13,15,20..26,39,98,100..102,110..117,175) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238579" Site order(193,248..250,253,268,275,278,281..282,285,307, 310..311,314) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238579" CDS 1..333 /gene="RBK1" /locus_tag="YCR036W" /coded_by="NM_001178750.1:1..1002" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Ribokinase, phosphorylates ribose to ribose-5-phosphate; required for recycling ribose during nucleotide metabolism" /db_xref="GeneID:850402" /db_xref="SGD:S000000632" ORIGIN 1 mgitvigsln ydldtftdrl pnagetfran hfethaggkg lnqaaaigkl knpssrysvr 61 mignvgndtf gkqlkdtlsd cgvdithvgt yegintgtat ilieekaggq nrilivegan 121 sktiydpkql ceifpegkee eeyvvfqhei pdplsiikwi hanrpnfqiv ynpspfkamp 181 kkdwelvdll vvneieglqi vesvfdnelv eeirekikdd flgeyrkice llyeklmnrk 241 krgivvmtlg srgvlfcshe spevqflpai qnvsvvdttg agdtflgglv tqlyqgetls 301 taikfstlas sltiqrkgaa esmplykdvq kda // LOCUS NP_009966 923 aa linear PLN 30-JUN-2025 DEFINITION SPX domain-containing inorganic phosphate transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_009966 VERSION NP_009966.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178751.1 REFERENCE 1 (residues 1 to 923) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 923) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 923) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 923) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07516. On Sep 29, 2000 this sequence version replaced NP_009966.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..923 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..923 /product="SPX domain-containing inorganic phosphate transporter" /calculated_mol_wt="102409" Region 1..334 /region_name="COG5408" /note="SPX domain-containing protein [Signal transduction mechanisms]" /db_xref="CDD:227695" Region 487..914 /region_name="SLC13_permease" /note="Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; cd01115" /db_xref="CDD:238535" Site order(494..497,504..517,544..561,585..601,603..620, 627..650,672,674..687,715..727,735..749,764..782,807..822, 842..861,897..909) /site_type="other" /note="transmembrane helices" /db_xref="CDD:238535" CDS 1..923 /gene="PHO87" /locus_tag="YCR037C" /coded_by="NM_001178751.1:1..2772" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21143198]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0005315 phosphate transmembrane transporter activity [PMID:11779791]" /experiment="EXISTENCE:genetic interaction:GO:0006817 phosphate ion transport [PMID:11779791]" /experiment="EXISTENCE:genetic interaction:GO:2000185 regulation of phosphate transmembrane transport [PMID:12821119]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:17804816]" /experiment="EXISTENCE:mutant phenotype:GO:0097080 plasma membrane selenite transport [PMID:20688911]" /note="Low-affinity inorganic phosphate (Pi) transporter; acts upstream of Pho81p in regulation of PHO pathway; targeted to vacuole via AP-3 pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication" /db_xref="GeneID:850403" /db_xref="SGD:S000000633" ORIGIN 1 mrfshflkyn avpewqnhyl dynelknliy tlqtdelkqe tptgdlndda dsqtpgpiad 61 iesniaagep ssskrrfthk lkrklfgskt psgskrgdsd ekaidgnnin eetieldels 121 pqgkttsfnk nfirkkffes rsssvssegk tlfssydtfv tnlsdeklkv ddfykrmeak 181 fyerfdhlin dlekegivtr lnetfnpeiq alpplreiis gtsethssnn pfeihssnid 241 selrnrfdys eeemdedddv dvfadttdnt allnysqfni ksqkksllkq tiinlyidlc 301 qlksfielnr mgfskitkks dkvlhmntrq elieseeffk dtyifqhetl sslnskiaql 361 iefyavlmgq pgnvdsckqe lksylhdhiv wersntwkdm lglssqnndi itiedeaekl 421 mqeklqieyf kyplpkpinl kftkienlav pklffgkram kigfiiivtg vllgvktfnd 481 pvehrcmalv eccaflwase aiplhitgll vplltvlfrv lkdddgkvmg aaaasteilg 541 tmwsstimil lagftlgeal sqynvakvla swllalagtk prnvllmams vvfflsmwis 601 nvaspvltys lltplldpld ytspfakalv mgvalsadig gmaspisspq niismqylkp 661 ygigwgqffa valptgilsm lcswalmilt fkigktklek fkpirtrfti kqyfiiivti 721 atillwcves qiesafgssg eiavipivlf fgtgllstkd fntfpwsivv lamggialgk 781 avsssgllvt iaralqkkiq ndgvfailci fgilmlvvgt fvshtvsaii iiplvqevgd 841 klsdpkaapi lvfgcallas cgmglassgf pnvtaismtd kkgnrwltvg afisrgvpas 901 llafvcvitl gygisssvlk gst // LOCUS NP_009967 642 aa linear PLN 30-JUN-2025 DEFINITION Ras family guanine nucleotide exchange factor BUD5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009967 VERSION NP_009967.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178752.1 REFERENCE 1 (residues 1 to 642) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 642) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 642) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 642) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07517. On Sep 29, 2000 this sequence version replaced NP_009967.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..642 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..642 /product="Ras family guanine nucleotide exchange factor BUD5" /calculated_mol_wt="74915" Region 230..339 /region_name="RasGEFN" /note="Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; smart00229" /db_xref="CDD:214571" Region 409..640 /region_name="RasGEF" /note="Guanine nucleotide exchange factor for Ras-like small GTPases; smart00147" /db_xref="CDD:214539" Site order(441..443,447..448,450..452,454..455,458..459,462,489, 492..493,495..497,499..502,504..505,522,525,530..532,535, 551..553,556..558,560..562,564..567,583,587,628,631..632) /site_type="other" /note="Ras interaction site [polypeptide binding]" /db_xref="CDD:238087" CDS 1..642 /gene="BUD5" /locus_tag="YCR038C" /coded_by="NM_001178752.1:1..1929" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11313501]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11313501]" /experiment="EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8234337|PMID:11589573]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:1905981]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:1905981]" /note="GTP/GDP exchange factor for Rsr1p (Bud1p); required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types" /db_xref="GeneID:850405" /db_xref="SGD:S000000634" ORIGIN 1 mspknkyvyi cveyiyiyfa kihkqstlss dttkmfvlid nvlaylleqd dlfvtarfai 61 qgqivsrrvn kihisnitdv llqqfishtl pyndnivpkk ildsmrtavr qlleatacvs 121 recplvkrsq dikrarkrll sdwyrlgada nmdavllvvn sawrflavwr pfvnsiqhat 181 qelyqniahy llhgnvniqr vtaliqlvmg qddllfsmdd vlqevfriql ylnkmlphns 241 hkwqkpspfd sanlllnfrd wttdnallqe lllsyptink nkhknhsvpr liqiwvesyw 301 qdsettlkdi lnfwyshlae yyeyqelfad ivqlfinkkr trqlkihyig ltdkeieenk 361 ppldyenlfl qyeidktnan delcgatdls dllfqwkqge lleveafaln vspwslaktl 421 tllesslyld ietieftrhf khndttidsv ftlsnqlssy vlettlqqth tisywlqval 481 sclylrnlns lasiitslqn hsierlslpi dvksdhlfqr lkvvvhpnnn ynvyrrtikh 541 ifhsqlpcvp ftsllirdit firdgndtft kdgnnvnmqk fnqitkivaf aqylqqkqye 601 dihcsnttar sllgamikvh tlyndnkdra yqvsiakvpr lt // LOCUS NP_009868 210 aa linear PLN 30-JUN-2025 DEFINITION homeodomain mating type protein alpha2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009868 VERSION NP_009868.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178753.1 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 210) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07518. On May 12, 2005 this sequence version replaced NP_009868.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..210 /product="homeodomain mating type protein alpha2" /calculated_mol_wt="24151" Site order(132..134,136,156,162,175,177..178,181..182,184..186, 188) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" Site order(132,135,178,181..182,185) /site_type="other" /note="specific DNA base contacts [nucleotide binding]" /db_xref="CDD:238039" Region 135..188 /region_name="HOX" /note="Homeodomain; smart00389" /db_xref="CDD:197696" CDS 1..210 /gene="MATALPHA2" /locus_tag="YCR039C" /gene_synonym="ALPHA2" /coded_by="NM_001178753.1:1..633" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:3893743]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:15598821]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1976249]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:7569974|PMID:7739902]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:3893743]" /note="Homeobox-domain protein; with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette" /db_xref="GeneID:850406" /db_xref="SGD:S000000635" ORIGIN 1 mnkipikdll npqitdefks sildinkklf siccnlpklp esvtteeeve lrdilgflsr 61 anknrkisde ekkllqttsq ltttitvllk emrsiendrs nyqltqknks adglvfnvvt 121 qdminkstkp yrghrftken vrileswfak nienpyldtk glenlmknts lsriqiknwv 181 snrrrkekti tiapeladll sgeplakkke // LOCUS NP_009869 175 aa linear PLN 30-JUN-2025 DEFINITION transcriptional co-activator mating type protein alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_009869 VERSION NP_009869.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178754.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 175) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07422. On May 12, 2005 this sequence version replaced NP_009869.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..175 /product="transcriptional co-activator mating type protein alpha" /calculated_mol_wt="20282" Region 84..>143 /region_name="MATalpha_HMGbox" /note="Mating-type protein MAT alpha 1 HMG-box; pfam04769" /db_xref="CDD:398438" CDS 1..175 /gene="MATALPHA1" /locus_tag="YCR040W" /gene_synonym="ALPHA1" /coded_by="NM_001178754.1:1..528" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:6337727]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:15118075]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:6337727]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:6337727]" /experiment="EXISTENCE:mutant phenotype:GO:0007532 regulation of mating-type specific transcription, DNA-templated [PMID:6337727]" /note="Transcriptional co-activator that regulates mating-type-specific genes; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette" /db_xref="GeneID:850407" /db_xref="SGD:S000000636" ORIGIN 1 mftskpafki knkasksyrn tavskklkek rlaehvrpsc fniirplkkd iqipvpssrf 61 lnkiqihria sgsqntqfrq fnktsikssk kylnsfmafr ayysqfgsgv kqnvlsslla 121 eewhadkmqh giwdyfaqqy nfinpgfgfv ewltnnyaev rgdgywedvf vhlal // LOCUS NP_001297596 110 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR041W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001297596 VERSION NP_001297596.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001310667.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 110) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA64811. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..110 /product="uncharacterized protein" /calculated_mol_wt="12756" CDS 1..110 /locus_tag="YCR041W" /coded_by="NM_001310667.1:1..333" /note="hypothetical protein; overexpression suppresses the high-frequency loss of mini-chromosomes, probably by increasing the rate of proper chromosome segregation; translated gene product of YCR041W, but not its transcript, is responsible for suppression; suppression ability of YCR041W is completely dependent on silencing protein Sir4p" /db_xref="GeneID:850408" /db_xref="SGD:S000000637" ORIGIN 1 mlkyvvtdig kmclyiwpyr vwswrrlfif rvlnvvsiai lfetphrlal vpnvclythm 61 aiplstclfc lclcicikyd itqtqannqf lasffvlilt indldvtfvi // LOCUS NP_009971 1407 aa linear PLN 30-JUN-2025 DEFINITION transcription initiation factor TFIID subunit TAF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009971 VERSION NP_009971.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178756.1 REFERENCE 1 (residues 1 to 1407) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1407) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1407) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07520. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1407 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1407 /product="transcription initiation factor TFIID subunit TAF2" /calculated_mol_wt="161341" Region 30..674 /region_name="M1_like_TAF2" /note="TATA binding protein (TBP) associated factor 2; cd09839" /db_xref="CDD:341074" Site order(191,211,213,218,221,483,486,506..508,560..561, 564..565,567..568,570..571,574,580,672) /site_type="other" /note="intramolecular interface [polypeptide binding]" /db_xref="CDD:341074" Site order(622..623,626,630,634,657) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:341074" CDS 1..1407 /gene="TAF2" /locus_tag="YCR042C" /gene_synonym="TAF150; TSM1" /coded_by="NM_001178756.1:1..4224" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10818000|PMID:12600943]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /note="TFIID subunit (150 kDa); involved in RNA polymerase II transcription initiation" /db_xref="GeneID:850409" /db_xref="SGD:S000000638" ORIGIN 1 mmsfsknatp raivsesstl hemkfrnfrv ahekisldid lathcitgsa tiiiipliqn 61 leyvtfdcke mtikdvlven rrcdqfihdd plqtnlnglt sqnvlysdns ieqshflrsk 121 faslneypet dsksqltiki pssikisled analsnytpi tpsikttpgf qesvftpitl 181 qieyeirnpk sgikfdtvya dkpwlwnvyt sngeicssas ywvpcvdlld ekstwelefs 241 vprlvknigt skligqngee sekekedtpe hdeeeegkpa rvikdedkds nlkndeegkn 301 skskdaqdnd eeeeegesde eeeegeeerr nieesnnpsl rdvivccsey snikelphpi 361 dltkkkcifq iinpvaphhi gwaigafnsw slplisppsv daedeveedk lrenvvdnvn 421 dtmdddigsd iipiqiftlp tqetdeltvi nstvvcqkii dfyskefgsy pftcysmvfl 481 ptapskhmdf aalgicntrl lyplevidka fsttnelawa lanqwscvni tpldmndywc 541 clgiagymvf qvtkklmgnn tykyqlkrns eaiveqdfek ppigstftgs srpiswsskd 601 lsfiqlkapm ilhildrrmt ktersfgmsr vlpkiflqam sgdlpnnslt sshfqhvcer 661 vnksklenff newvygsgvp ilrvtqrfnr krmvielgir qvqdeelghe kvvgeegffk 721 saldhlehpd lnrtecftgs mtirihehdg tpyehiveik dtftkidiqy ntkyrrlrkr 781 gggandengv ennneekpiv vdvnclgnvy mspeecsrfs ltefnrtses nellkqneaf 841 ewiridsdle wicqmhinqp dymfssqlrq dgdieaqlea iryyedvvvn ggvkslvyss 901 ilfrtaider yffgirlaac ealskyvydp dftggvkhli qifqilfcle dsnipksnnf 961 enpklyflqc nipkylakvk nengkcpklv kqflldilvy nengenkysd dayvrslien 1021 vvkvalneyk dkaymekvkt qllryenlvn wlssyeslik ttimyakykl hkvgaydfte 1081 ltgmimhtlt lginngdisr esfqneflmv lkimlleggl knkdalvlft eilcfhedsy 1141 irdksvdvls ecvnlvvmdg sldtisddik ssvqsvhnev knikseddie lflsghyvdd 1201 mkikiekigr qnisgliqic rdmfkgyspl killwdvlnl pvlslyqrkq ihdlvrvmyt 1261 linsfvvrle tprerrlvak mnsneegkld ivikresilk vhikkevtst veapkkanki 1321 kislkgdkpv rkvekqivkp kvtskqrkvk shvnrmgslp lrfvkiqqqp rvmvhlssvp 1381 ysqfvqitkv tsrsfmvkir tkndakn // LOCUS NP_009972 127 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR043C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009972 VERSION NP_009972.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178757.1 REFERENCE 1 (residues 1 to 127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 127) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07521. Method: conceptual translation. FEATURES Location/Qualifiers source 1..127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..127 /product="uncharacterized protein" /calculated_mol_wt="14648" CDS 1..127 /locus_tag="YCR043C" /coded_by="NM_001178757.1:1..384" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene" /db_xref="GeneID:850410" /db_xref="SGD:S000000639" ORIGIN 1 mipapldasl lrehafqgtn dlstvlspst ftdeggykpv lkyglgyfny glviddevyd 61 ysvcdiirgh vydhfwcyfc cfmilftiwl islnwcpssk kskfdwskkk ddfkmeggdl 121 eyqhvki // LOCUS NP_009973 357 aa linear PLN 30-JUN-2025 DEFINITION Per1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009973 VERSION NP_009973.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178758.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 357) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07522. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..357 /product="Per1p" /calculated_mol_wt="42411" Region 1..357 /region_name="PER1" /note="Predicted membrane protein [Function unknown]; COG5237" /db_xref="CDD:227562" CDS 1..357 /gene="PER1" /locus_tag="YCR044C" /gene_synonym="COS16" /coded_by="NM_001178758.1:1..1074" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:9560393]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17021251]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:17021251]" /experiment="EXISTENCE:mutant phenotype:GO:0030026 intracellular manganese ion homeostasis [PMID:9560393]" /note="Protein of the endoplasmic reticulum; required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1" /db_xref="GeneID:850411" /db_xref="SGD:S000000640" ORIGIN 1 mrlavvvtll vhcflvtcsp gdnldefidc tyaceynrrc pnsqinyidp etnmfhdief 61 fdtpplyskl lfwdcisdcd yqcqhiitrw rideeeeiyq fhgkwpflrv lgtqeffsti 121 fsignfiphy kgfvkfsrii reegdrrrkn srsiliwnyl yvtvagmlaw tassvfhcrd 181 liitekldyf fagltvltgf haifarmtsm flypkiaqaf tasvaaifal hilrlyvdws 241 ytynmrfnif fgvlqyilli mlscqnyhal qkqklmgefk ktayssfkrq ifklcvipil 301 lvivttmams lelfdffsye wqidahalwh lctiwpswvl ydffledyay wgnrqly // LOCUS NP_009974 491 aa linear PLN 30-JUN-2025 DEFINITION Rrt12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009974 VERSION NP_009974.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178759.1 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 491) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07523. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..491 /product="Rrt12p" /calculated_mol_wt="54937" Region 130..398 /region_name="Peptidases_S8_PCSK9_ProteinaseK_like" /note="Peptidase S8 family domain in ProteinaseK-like proteins; cd04077" /db_xref="CDD:173790" Site order(133,136..137) /site_type="other" /note="calcium binding site 2 [ion binding]" /db_xref="CDD:173790" Site order(174,205,271..272,299,362,365) /site_type="active" /db_xref="CDD:173790" Site order(174,205,365) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:173790" Site order(313,315,339) /site_type="other" /note="calcium binding site 1 [ion binding]" /db_xref="CDD:173790" CDS 1..491 /gene="RRT12" /locus_tag="YCR045C" /gene_synonym="OSW3" /coded_by="NM_001178759.1:1..1476" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:19779569]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:19779569]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:19779569]" /note="Probable subtilisin-family protease; role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores" /db_xref="GeneID:850412" /db_xref="SGD:S000000641" ORIGIN 1 mkpqcilisl lvnlayaeey lvrfknptaf qqftsnsnrs wrqfidnkie kkfsigsfrg 61 vtmnlsknlv nklkksplva divpnfrfea fegdsvnsae ssytfnatak ysyedveeeq 121 nityqpdapr hlarisrhyq lpfdvgdkdr ykswfnyyye hdyqgqdvna yimdtgifad 181 hpefedrviq gidltkegfg dqnghgthva glvgsktyga akrvnlvevk vlgkdgsgea 241 snvlsglefi vehctkvsrp qgkkcvanls lgsfrspiin mavegaieeg ivfvaaagnf 301 nldaywaspa saenvitvga fddhidtiak fsnwgpcvni fapgveiesl shlnyndtli 361 lsgtsmstpi vtgvaaills kgiepemiaq eieylstrnv fhrrtlffkp stpnqilyng 421 vdklddpydd etfprlniea iakeleeyna tlqtpmsenl qsgsklwgwn ndvtlplgei 481 rlkrrdfmkn l // LOCUS NP_009975 169 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL19m IMG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009975 VERSION NP_009975.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178760.1 REFERENCE 1 (residues 1 to 169) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 169) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 169) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 169) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07524. Method: conceptual translation. FEATURES Location/Qualifiers source 1..169 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..169 /product="mitochondrial 54S ribosomal protein bL19m IMG1" /calculated_mol_wt="19263" CDS 1..169 /gene="IMG1" /locus_tag="YCR046C" /gene_synonym="bL19m" /coded_by="NM_001178760.1:1..510" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit; required for respiration and for maintenance of the mitochondrial genome" /db_xref="GeneID:850413" /db_xref="SGD:S000000642" ORIGIN 1 mwsrnvrllg swtrsymvpa tkrktipvyp pvqriassqi mkqvalseie sldpgavkrk 61 liskknkdrl kagdvvrivy dsskcsydtf vgyilsidrk qlvqdaslll rnqiaktave 121 irvplfspli eridlltphv ssrqrnkhyy irgtrldvgd leaglrrkk // LOCUS NP_009976 275 aa linear PLN 30-JUN-2025 DEFINITION 18S rRNA (guanine1575-N7)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009976 VERSION NP_009976.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178761.1 REFERENCE 1 (residues 1 to 275) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 275) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 275) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 275) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07525. Method: conceptual translation. FEATURES Location/Qualifiers source 1..275 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..275 /product="18S rRNA (guanine1575-N7)-methyltransferase" /EC_number="2.1.1.309" /calculated_mol_wt="30611" Region 38..179 /region_name="UbiE" /note="Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; COG2226" /db_xref="CDD:441828" Region <226..273 /region_name="WBS_methylT" /note="Methyltransferase involved in Williams-Beuren syndrome; pfam12589" /db_xref="CDD:432656" CDS 1..275 /gene="BUD23" /locus_tag="YCR047C" /coded_by="NM_001178761.1:1..828" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:18332120]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:18332120]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:18332120]" /experiment="EXISTENCE:mutant phenotype:GO:0016435 rRNA (guanine) methyltransferase activity [PMID:18332120]" /experiment="EXISTENCE:mutant phenotype:GO:0070476 rRNA (guanine-N7)-methylation [PMID:18332120]" /note="Ribosome biogenesis factor; methyltransferase that methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; required for recruitment of Rps2p; functions with DEAH-box RNA helicase Ecm16p; diploid mutant displays random budding pattern; functional homolog of human WBSCR22" /db_xref="GeneID:850414" /db_xref="SGD:S000000643" ORIGIN 1 msrpeelapp eifyndseah kytgstrvqh iqakmtlral ellnlqpcsf ildigcgsgl 61 sgeiltqegd hvwcgldisp smlatglsre legdlmlqdm gtgipfrags fdaaisisai 121 qwlcnadtsy ndpkqrlmrf fntlyaalkk ggkfvaqfyp knddqvddil qsakvagfsg 181 glvvddpesk knkkyylvls sgappqgeeq vnldgvtmde envnlkkqlr qrlkggkdke 241 saksfilrkk elmkrrgrkv akdskftgrk rrhrf // LOCUS NP_009978 610 aa linear PLN 30-JUN-2025 DEFINITION sterol acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_009978 VERSION NP_009978.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178762.1 REFERENCE 1 (residues 1 to 610) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 610) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 610) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 610) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07526. Method: conceptual translation. FEATURES Location/Qualifiers source 1..610 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..610 /product="sterol acyltransferase" /calculated_mol_wt="71482" Region 96..610 /region_name="ARE1" /note="Acyl-CoA cholesterol acyltransferase [Lipid metabolism]; COG5056" /db_xref="CDD:227389" CDS 1..610 /gene="ARE1" /locus_tag="YCR048W" /gene_synonym="SAT2" /coded_by="NM_001178762.1:1..1833" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:10672016]" /experiment="EXISTENCE:genetic interaction:GO:0034737 ergosterol O-acyltransferase activity [PMID:10672016]" /experiment="EXISTENCE:genetic interaction:GO:0034738 lanosterol O-acyltransferase activity [PMID:10672016]" /experiment="EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:10672016]" /experiment="EXISTENCE:mutant phenotype:GO:0034738 lanosterol O-acyltransferase activity [PMID:10672016]" /note="Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication" /db_xref="GeneID:850415" /db_xref="SGD:S000000644" ORIGIN 1 mtetkdllqd eeflkirrln saeankrhsv tydnvilpqe smevsprsst tslvepvest 61 egvesteaer vagkqeqeee ypvdahmqky lshlksksrs rfhrkdasky vsffgdvsfd 121 prptlldsai nvpfqttfkg pvlekqlknl qltktktkat vkttvkttek tdkadappge 181 klesnfsgiy vfawmflgwi aircctdyya sygsawnkle ivqymttdlf tiamldlamf 241 lctffvvfvh wlvkkriinw kwtgfvavsi felafipvtf piyvyyfdfn wvtriflflh 301 svvfvmkshs fafyngylwd ikqeleyssk qlqkykesls petreilqks cdfclfelny 361 qtkdndfpnn iscsnffmfc lfpvlvyqin yprtsrirwr yvlekvcaii gtiflmmvta 421 qffmhpvamr ciqfhntptf ggwipatqew fhllfdmipg ftvlymltfy miwdallncv 481 aeltrfadry fygdwwncvs feefsriwnv pvhkfllrhv yhssmgalhl sksqatlftf 541 flsavfhema mfaifrrvrg ylfmfqlsqf vwtalsntkf lrarpqlsnv vfsfgvcsgp 601 siimtlyltl // LOCUS NP_009979 102 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR050C [Saccharomyces cerevisiae S288C]. ACCESSION NP_009979 VERSION NP_009979.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178764.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 102) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07527. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..102 /product="uncharacterized protein" /calculated_mol_wt="11586" CDS 1..102 /locus_tag="YCR050C" /coded_by="NM_001178764.1:1..309" /note="Non-essential hypothetical protein; deletion mutant is synthetically sick or lethal with alpha-synuclein" /db_xref="GeneID:850417" /db_xref="SGD:S000000646" ORIGIN 1 mvavhkvryn vimilgpeqt pnekttldnc glarrnlvll kavhtncdsw nmnrypltll 61 kmanmaiswn talkkkvnnv awlllkcnap melwytclsk nl // LOCUS NP_009980 222 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR051W [Saccharomyces cerevisiae S288C]. ACCESSION NP_009980 VERSION NP_009980.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178765.1 REFERENCE 1 (residues 1 to 222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 222) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07528. Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..222 /product="uncharacterized protein" /calculated_mol_wt="24563" Region 5..34 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(6..7,10..12,14..15,19,24,34,36,38,42..43,46..48, 50..51,55,59,68,70,72,76..77,78..79,81..82,86,89,99) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region <7..172 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 36..68 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 70..99 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..222 /locus_tag="YCR051W" /coded_by="NM_001178765.1:1..669" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene" /db_xref="GeneID:850418" /db_xref="SGD:S000000647" ORIGIN 1 mnaniwvaas dgnldrvehi lreskgamtp qskdingytp mhaaaayghl dllkkmcney 61 ngdinvldnd gdtplhhved vatarlivee lggdftirnv egqtpydsfv engedgelie 121 ymriksgvad vhgvdgvqge gvidskllee fkdnvrytle ndpeegadea tlqrrrqleq 181 iitgdnaeee leryiramvr eqmlgqgsma gsgdepdskr rk // LOCUS NP_009981 483 aa linear PLN 30-JUN-2025 DEFINITION Rsc6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009981 VERSION NP_009981.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178766.1 REFERENCE 1 (residues 1 to 483) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 483) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 483) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 483) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07529. Method: conceptual translation. FEATURES Location/Qualifiers source 1..483 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..483 /product="Rsc6p" /calculated_mol_wt="54034" Region 234..>272 /region_name="SWIB-MDM2" /note="SWIB/MDM2 domain family; cl38907" /db_xref="CDD:476812" CDS 1..483 /gene="RSC6" /locus_tag="YCR052W" /coded_by="NM_001178766.1:1..1452" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:31886770]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:31886770]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019|PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:17081996]" /note="Component of the RSC chromatin remodeling complex; essential for mitotic growth; RSC6 has a paralog, SNF12, that arose from the whole genome duplication" /db_xref="GeneID:850419" /db_xref="SGD:S000000648" ORIGIN 1 mvtqtnpvpv typtdayipt ylpddkvsnl adlkkliemd srldlyltrr rldtsinlpt 61 ntktkdhppn kemlriyvyn ttessprsds gtpadsgktt wtlriegkll hesangkhpf 121 seflegvavd fkrlkplgmg kkrkrdssls lplnlqqpey ndqdstmgdn dngededsae 181 aesreeivda lewnydennv vefdgidikr qgkdnlrcsi tiqlrgvdgg kvqyspnlat 241 ligmqtgsvn davysiykyi linnlfvteq teaqdgsnda edssnennnk ngagdddgve 301 gstpkdkpel gevkldsllq kvldtnaahl plmnvvqtvn klvsplppii ldytidlskd 361 ttygattldv dvshilhqpq pqpnlqkeee tdaedtaklr eitklalqln ssaqkyqffh 421 elslhpretl thylwsskqn elvlqgdqyf nedaartsdi ysnnnndrsl mgnisllysq 481 grl // LOCUS NP_009982 514 aa linear PLN 30-JUN-2025 DEFINITION threonine synthase THR4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009982 VERSION NP_009982.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178767.1 REFERENCE 1 (residues 1 to 514) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 514) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 514) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 514) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07530. Method: conceptual translation. FEATURES Location/Qualifiers source 1..514 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..514 /product="threonine synthase THR4" /EC_number="4.2.3.1" /calculated_mol_wt="57343" Region 8..479 /region_name="Thr-synth_2" /note="Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; cd01560" /db_xref="CDD:107203" Site order(124,277..278,449) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:107203" Site 124 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:107203" CDS 1..514 /gene="THR4" /locus_tag="YCR053W" /coded_by="NM_001178767.1:1..1545" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004795 threonine synthase activity [PMID:8082795]" /experiment="EXISTENCE:mutant phenotype:GO:0009088 threonine biosynthetic process [PMID:8082795]" /note="Threonine synthase; conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway" /db_xref="GeneID:850420" /db_xref="SGD:S000000649" ORIGIN 1 mpnasqvyrs trssspktis feeaiiqgla tdgglfippt ipqvdqatlf ndwsklsfqd 61 lafaimrlyi aqeeipdadl kdlikrsyst frsdevtplv qnvtgdkenl hilelfhgpt 121 yafkdvalqf vgnlfeyflq rtnanlpege kkqitvvgat sgdtgsaaiy glrgkkdvsv 181 filyptgris piqeeqmttv pdenvqtlsv tgtfdncqdi vkaifgdkef nskhnvgavn 241 sinwarilaq mtyyfysffq atngkdskkv kfvvpsgnfg dilagyfakk mglpieklai 301 atnendildr flksglyers dkvaatlspa mdilissnfe rllwylarey langddlkag 361 eivnnwfqel ktngkfqvdk siiegaskdf tservsneet setikkiyes svnpkhyild 421 phtavgvcat erliakdndk siqyislsta hpakfadavn nalsgfsnys fekdvlpeel 481 kklstlkkkl kfieradvel vknaieeela kmkl // LOCUS NP_009983 563 aa linear PLN 30-JUN-2025 DEFINITION Ctr86p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009983 VERSION NP_009983.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178768.1 REFERENCE 1 (residues 1 to 563) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 563) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 563) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 563) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07531. Method: conceptual translation. FEATURES Location/Qualifiers source 1..563 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..563 /product="Ctr86p" /calculated_mol_wt="65075" Region 446..544 /region_name="Atx10homo_assoc" /note="Spinocerebellar ataxia type 10 protein domain; pfam09759" /db_xref="CDD:462885" CDS 1..563 /gene="CTR86" /locus_tag="YCR054C" /coded_by="NM_001178768.1:1..1692" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /note="Essential hypothetical protein; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:850421" /db_xref="SGD:S000000650" ORIGIN 1 mpmnnfldef nlfdsiitmm kndpccvedy epivenlnri fqrtfndeeh rksmansqlf 61 werlrdtlea mllpaslnen ssipytrtvr glilmmrnla aenqeipqkl llqnlvirgf 121 lhatseyvvd tplikhlyia cltclfniqq nystvdmttf pallqflqyp ygikledgee 181 eehfwlpylf lfktylnnde fsneffrdnd tpqkdyycvr driffdivta kfiqdqensf 241 liekgrnyld dskleitsid lsvlecisks lttasfgkyl ngleerqpgk fttllqilql 301 vvtskedwnt yeltaimswc ypilqrlack dipaffnksc ndyapsvaiq lhstllscld 361 iisdlckfnh vrkflisyds vkilvslldt fqknllrinf lkgngdtvne ikitdhegnk 421 iedrllifnr vntnesfira dnfphcklvi ieilaslvya hpeiqdqire lgglalilsn 481 cviddndpfi kersivclkf llknnaknqe yvkkmeaqdv vqddalskag feisvekggk 541 vrlvskeedp gnenseiisi ded // LOCUS NP_009984 923 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-binding rRNA-processing protein PWP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009984 VERSION NP_009984.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178769.1 REFERENCE 1 (residues 1 to 923) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 923) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 923) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 923) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07532. Method: conceptual translation. FEATURES Location/Qualifiers source 1..923 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..923 /product="snoRNA-binding rRNA-processing protein PWP2" /calculated_mol_wt="103853" Region <20..177 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 58..94 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 99..144 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 104..502 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 150..189 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 194..220 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 265..300 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 306..343 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 348..384 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 391..426 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 433..470 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 476..513 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 479..561 /region_name="ANAPC4_WD40" /note="Anaphase-promoting complex subunit 4 WD40 domain; pfam12894" /db_xref="CDD:403945" Region 518..542 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 580..616 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 746..851 /region_name="Utp12" /note="Dip2/Utp12 Family; pfam04003" /db_xref="CDD:461125" CDS 1..923 /gene="PWP2" /locus_tag="YCR057C" /gene_synonym="UTP1; YCR055C; YCR058C" /coded_by="NM_001178769.1:1..2772" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309|PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8804409]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:15231838|PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034388 Pwp2p-containing subcomplex of 90S preribosome [PMID:15231838|PMID:17515605]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15231838|PMID:15489292|PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15231838|PMID:15590835|PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15231838|PMID:15590835|PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:8804409]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:8804409]" /note="Conserved 90S pre-ribosomal component; essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis" /db_xref="GeneID:850422" /db_xref="SGD:S000000653" ORIGIN 1 mksdfkfsnl lgtvyrqgni tfsddgkqll spvgnrvsvf dlinnksftf eyehrkniaa 61 idlnkqgtll isidedgrai lvnfkarnvl hhfnfkekcs avkfspdgrl falasgrflq 121 iwktpdvnkd rqfapfvrhr vhaghfqdit sltwsqdsrf ilttskdlsa kiwsvdseek 181 nlaattfngh rdyvmgaffs hdqekiytvs kdgavfvwef tkrpsddddn esedddkqee 241 vdiskyswri tkkhffyanq akvkcvtfhp atrllavgft sgefrlydlp dftliqqlsm 301 gqnpvntvsv nqtgewlafg ssklgqllvy ewqsesyilk qqghfdstns layspdgsrv 361 vtasedgkik vwditsgfcl atfeehtssv tavqfakrgq vmfsssldgt vrawdliryr 421 nfrtftgter iqfnclavdp sgevvcagsl dnfdihvwsv qtgqlldals ghegpvscls 481 fsqensvlas aswdktiriw sifgrsqqve pievysdvla lsmrpdgkev avstlkgqis 541 ifniedakqv gnidcrkdii sgrfnqdrft aknserskff ttihysfdgm aivaggnnns 601 iclydvpnev llkrfivsrn malngtlefl nskkmteags ldliddagen sdledridns 661 lpgsqrggdl strkmrpevr vtsvqfspta nafaaasteg lliystndti lfdpfdldvd 721 vtphstveal rekqflnalv mafrlneeyl inkvyeaipi keiplvasni paiylprilk 781 figdfaiesq hiefnliwik allsasggyi nehkylfsta mrsiqrfivr vakevvnttt 841 dnkytyrflv stdgsmedga adddevllkd dadedneene endvvmesdd eegwigfngk 901 dnklplsnen dssdeeenek elp // LOCUS NP_009985 258 aa linear PLN 30-JUN-2025 DEFINITION Yih1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009985 VERSION NP_009985.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178770.1 REFERENCE 1 (residues 1 to 258) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 258) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 258) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 258) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07533. Method: conceptual translation. FEATURES Location/Qualifiers source 1..258 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..258 /product="Yih1p" /calculated_mol_wt="28886" Region 8..112 /region_name="RWD_ScYIH1-like" /note="RWD domain of Saccharomyces cerevisiae protein YIH1 and related proteins; cd23822" /db_xref="CDD:467658" Region 144..251 /region_name="UPF0029" /note="Uncharacterized protein family UPF0029; pfam01205" /db_xref="CDD:460111" CDS 1..258 /gene="YIH1" /locus_tag="YCR059C" /coded_by="NM_001178770.1:1..777" /experiment="EXISTENCE:direct assay:GO:0003785 actin monomer binding [PMID:15126500]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:22404850]" /experiment="EXISTENCE:mutant phenotype:GO:0001933 negative regulation of protein phosphorylation [PMID:15126500]" /experiment="EXISTENCE:mutant phenotype:GO:0004860 protein kinase inhibitor activity [PMID:15126500]" /note="Negative regulator of eIF2 kinase Gcn2p; competes with Gcn2p for binding to Gcn1p; may contribute to regulation of translation in response to starvation via regulation of Gcn2p; binds to monomeric actin and to ribosomes and polyribosomes; ortholog of mammalian IMPACT" /db_xref="GeneID:850423" /db_xref="SGD:S000000655" ORIGIN 1 mdddheqlve eleaveaiyp dllskkqedg siivvkvpqh eymtlqisfp thypseeapn 61 vievgvctsl akrdlydtky lqhlfqevmd svfhrgsvcl fdflteldgv lyvepeeete 121 pvqqsdiptd pfegwtasdp itdrgstfma faahvtseeq afamldllkt dskmrkanhv 181 msawrikqdg saatyqdsdd dgetaagsrm lhlitimdvw nvivvvarwf ggahigpdrf 241 khinstarea vvragfds // LOCUS NP_009986 111 aa linear PLN 30-JUN-2025 DEFINITION Tah1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009986 VERSION NP_009986.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178771.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 111) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07534. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..111 /product="Tah1p" /calculated_mol_wt="12380" Region 8..32 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region <11..>66 /region_name="Spy" /note="Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; COG3914" /db_xref="CDD:443119" Region 37..67 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..111 /gene="TAH1" /locus_tag="YCR060W" /coded_by="NM_001178771.1:1..336" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:18412542]" /experiment="EXISTENCE:direct assay:GO:0097255 R2TP complex [PMID:15766533]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:15766533]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:18268103]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15766533]" /experiment="EXISTENCE:mutant phenotype:GO:0051087 protein-folding chaperone binding [PMID:15766533]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:15766533]" /experiment="EXISTENCE:physical interaction:GO:0051087 protein-folding chaperone binding [PMID:15766533]" /experiment="EXISTENCE:physical interaction:GO:0097255 R2TP complex [PMID:18268103]" /note="Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly of large protein complexes such as box C/D snoRNPs and RNA polymerase II; contains a single TPR domain with at least two TPR motifs; plays a role in determining prion variants" /db_xref="GeneID:850424" /db_xref="SGD:S000000656" ORIGIN 1 msqfekqkeq gnslfkqgly reavhcydql itaqpqnpvg ysnkamalik lgeytqaiqm 61 cqqglrytst aehvairskl qyrlelaqga vgsvqipvve vdelpegydr s // LOCUS NP_009987 631 aa linear PLN 30-JUN-2025 DEFINITION Tvs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009987 VERSION NP_009987.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178772.1 REFERENCE 1 (residues 1 to 631) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 631) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 631) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 631) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07535. On Sep 29, 2000 this sequence version replaced NP_009987.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..631 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..631 /product="Tvs1p" /calculated_mol_wt="70791" Region 96..188 /region_name="DUF2427" /note="Domain of unknown function (DUF2427); pfam10348" /db_xref="CDD:402114" Region 331..621 /region_name="Ytp1" /note="Protein of unknown function (Ytp1); pfam10355" /db_xref="CDD:431228" CDS 1..631 /gene="TVS1" /locus_tag="YCR061W" /gene_synonym="YCR062W" /coded_by="NM_001178772.1:1..1896" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; non-essential gene; upregulated by and required for tolerance to 4-Methylcyclohexane methanol; induced by treatment with 8-methoxypsoralen and UVA irradiation; contains 10-11 predicted transmembrane domains" /db_xref="GeneID:850425" /db_xref="SGD:S000000657" ORIGIN 1 mvrfvsilsl fgcaatlvta hddmdmdmdm dmdmdmnidt ttsqsidvss tasivpvphe 61 pkhlhglpil qspsltpaer lywenynttt yfttqagnrs alryhiitll lvafvlypvs 121 lalsaarsrw ylpllfvnlc icissvmals vfkntfpeed wyahniygtt svlllvfmlv 181 hffaavlsvp vslaskkeyr pvdtiplndl estpvmvnsa rgspspssnr dtlfslssdt 241 ttatatnnnk rrraegedeg dntsnhdtlr dedydnddde iasieappll pqdipvfril 301 ftntkyqmla ahlscvanvv fhmltyplfm yifvdliigf avgnllgkgi rifnllahwi 361 kggvfftlgv vslarycgfa akygwawnni sftsqltqtr ssnllfrfap agtftmefve 421 sfliffygst niflehlagn ggawtakdlq hvsiafmfig tglcglltey klnhwrfeha 481 rkrpqtdvva atpgyspnpf paftifwtgi lmsqhaqssq fsttihtqwg yllsygsffr 541 lltflilflv pntnsaaskp ftelitsfcl lcgglvfmes tdqsieamey rgftpmftfn 601 lsvgfvsllm awemilfiwk dwliktrkts l // LOCUS NP_009990 157 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit BUD31 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009990 VERSION NP_009990.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178774.1 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 157) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07536. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..157 /product="U2 snRNP complex subunit BUD31" /calculated_mol_wt="18316" Region 1..155 /region_name="G10" /note="G10 protein; pfam01125" /db_xref="CDD:426066" CDS 1..157 /gene="BUD31" /locus_tag="YCR063W" /gene_synonym="CWC14" /coded_by="NM_001178774.1:1..474" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:16314500]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:11452010]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16314500|PMID:15303280]" /note="Component of the SF3b subcomplex of the U2 snRNP; increases efficiency of first and second step pre-mRNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis" /db_xref="GeneID:850427" /db_xref="SGD:S000000659" ORIGIN 1 mpriktrrsk papdgfekik ptltdfeiql rdaqkdkssk laaksneqlw eimqlhhqrs 61 ryiytlyykr kaiskdlydw likekyadkl liakwrktgy eklcclrciq knetnngstc 121 icrvpraqle eearkkgtqv sfhqcvhcgc rgcastd // LOCUS NP_009991 564 aa linear PLN 30-JUN-2025 DEFINITION Hcm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009991 VERSION NP_009991.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178776.1 REFERENCE 1 (residues 1 to 564) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 564) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 564) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 564) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07537. On Sep 29, 2000 this sequence version replaced NP_009991.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..564 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..564 /product="Hcm1p" /calculated_mol_wt="63516" Region 20..564 /region_name="COG5025" /note="Transcription factor of the Forkhead/HNF3 family [Transcription]" /db_xref="CDD:227358" CDS 1..564 /gene="HCM1" /locus_tag="YCR065W" /coded_by="NM_001178776.1:1..1695" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:16912276]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20847055|PMID:19159085]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20847055]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:33339134]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8441413]" /experiment="EXISTENCE:genetic interaction:GO:0051300 spindle pole body organization [PMID:9920414]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:16912276]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:20847055]" /experiment="EXISTENCE:mutant phenotype:GO:0034246 mitochondrial transcription factor activity [PMID:33339134]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:20847055]" /experiment="EXISTENCE:mutant phenotype:GO:1903108 regulation of mitochondrial transcription [PMID:33339134]" /note="Forkhead transcription factor; drives S-phase activation of genes involved in chromosome segregation, spindle dynamics, budding; also activates genes involved in respiration, use of alternative energy sources, NAD synthesis, oxidative stress resistance; regulated by cell wall integrity checkpoint; key factor in early adaptation to nutrient deficiency and diauxic shift; suppressor of calmodulin mutants with specific SPB assembly defects; ortholog of C. elegans lifespan regulator PHA-4" /db_xref="GeneID:850429" /db_xref="SGD:S000000661" ORIGIN 1 mmnedisiid ghnsflteks tvlltqakrt ledekemitp psstvrktmk evnkrpshpl 61 spdhsspiap skakrqrsdt carsngnltl eeilqslerr ringelakkp pysyatlicl 121 ailqsqegkl tlsqiyhwih vhfpyykqkd aswqnsirhn lslndafikt ekscdgkghf 181 wevrpgaetk ffkgenrgye fvkdslqdig kyfeidstld eleqvesgeg nddlpdeeer 241 eeagkfpsie iqlnsspilr vsqlhhipql ktdnsvlnph enlesmrnmi endvnnidsl 301 eppyvmkkyh tslglpslvn akdhfqagvk nnnitqanrf ntlpitsaks pqnfrkyfts 361 fnsnfedlsp lrsnvgagsl ldplpysplk lydqknlalm skpqsqqsys nsqlppppss 421 hgsdllktpk mrhsdglekt psrlistpkd gnsilrkwqt pshlfedlyc splfraietp 481 iryittpggt letqisprks sapdvltsat nskfassglf gvdvysvwkr atekisdgnn 541 ttdsnqkhhp yhnhpsndsg nekn // LOCUS NP_009992 487 aa linear PLN 30-JUN-2025 DEFINITION E3 ubiquitin-protein ligase RAD18 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009992 VERSION NP_009992.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178777.1 REFERENCE 1 (residues 1 to 487) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 487) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 487) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 487) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07538. Method: conceptual translation. FEATURES Location/Qualifiers source 1..487 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..487 /product="E3 ubiquitin-protein ligase RAD18" /EC_number="2.3.2.27" /calculated_mol_wt="55099" Region 1..470 /region_name="RAD18" /note="RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]; COG5432" /db_xref="CDD:227719" CDS 1..487 /gene="RAD18" /locus_tag="YCR066W" /coded_by="NM_001178777.1:1..1464" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10880451]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:7926769|PMID:9287349]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10880451]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:9287349]" /experiment="EXISTENCE:direct assay:GO:0097505 Rad6-Rad18 complex [PMID:9287349]" /experiment="EXISTENCE:genetic interaction:GO:0042275 error-free postreplication DNA repair [PMID:9576943|PMID:10924462]" /experiment="EXISTENCE:genetic interaction:GO:0042276 error-prone translesion synthesis [PMID:15687278|PMID:11973297]" /experiment="EXISTENCE:genetic interaction:GO:0070987 error-free translesion synthesis [PMID:9409821]" /experiment="EXISTENCE:mutant phenotype:GO:0006513 protein monoubiquitination [PMID:12226657]" /note="E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA" /db_xref="GeneID:850430" /db_xref="SGD:S000000662" ORIGIN 1 mdhqittasd ftttsipsly qldtllrchi ckdflkvpvl tpcghtfcsl cirthlnnqp 61 ncplclfefr esllrseflv seiiqsytsl rsslldalri pkptpvpene evpgpenssw 121 ielisesesd svnaadddlq ivatserkla krsmtdilpl sskpskrnfa mfrserikkk 181 skpneqmaqc picqqfyplk alekthldec ltlqslgkkp kisttfptes nphnksssrf 241 kvrtpevdks scgetshvdk ylnsmmsaeh qrlpkinfts mtqsqikqkl sslglstngt 301 rqnmikrynh yemlwnsnfc dslepvdeae lkrqllswdv shnktpqnss nkggisklmi 361 mksngksssy rkllenfknd kfnrkgwmvm frkdfarlir eakmkiktgs sdssgsvghs 421 ndgdgvekvq sdqgtedqqm ekdqdtvine drvagernlp nedstdadls relmdlneys 481 kdppgnn // LOCUS NP_009993 1065 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein SED4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009993 VERSION NP_009993.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178778.1 REFERENCE 1 (residues 1 to 1065) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1065) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1065) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1065) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1065) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1065) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1065) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1065) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1065) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07539. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1065 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1065 /product="GTPase-activating protein SED4" /calculated_mol_wt="113949" Region <142..335 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 172..209 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 214..253 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 265..300 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..1065 /gene="SED4" /locus_tag="YCR067C" /coded_by="NM_001178778.1:1..3198" /experiment="EXISTENCE:direct assay:GO:0003400 regulation of COPII vesicle coating [PMID:21291503]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:21291503]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:7593162]" /note="Integral ER membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; SED4 has a paralog, SEC12, that arose from the whole genome duplication" /db_xref="GeneID:850431" /db_xref="SGD:S000000663" ORIGIN 1 msgnsanydv gypiygakfi negtllvagg ggqfnssfpn kitalkvnfq kkkhirrfre 61 itldsiddap tsldcnnnli lvgcnelfnd ssmenvnhhl rkfvfeqehl kfvasidfnr 121 ttdpsvftkf vyinqratva aiassevptv iriidprnlt enyeietgre vndlhfapng 181 illsyitsns levasvrdgn fvarktdfdk nlvlsnirfl ndntllvaas lsnsdgvsll 241 klgvsskgvk ilktasfmfd lngitsmdvs pnkkfvalss ndnlvaivsv eklklvqlvp 301 rvhestitkv tfspdsryla stsmgntinv lklsgtsssi lrniwkffln fvllvvlaga 361 iqlgykhnvh gfiykhahdi ykskfkentt idqgsssyft inddyrgite sadiisatdv 421 asdietefss fdtstmrttt edeqkfvwis ssadsqftsa diptsassss ssssssfyee 481 svtnepivss ptseitkpla sptepnivek pslplnsesi dllssssnsi teypeptpdl 541 eeklsslive qseseittdr esvskllste spslshmpss sssslslsss lttspttals 601 tstatavttt qtnptndaan tsfldnskpa streiyktki itevitkiey rnipasdsna 661 eaeqyvttss smlltptdtm vsspvseidp iaselermve tpthsisias efdsvasnli 721 pneeilstsa sqdsisshps tfsdssitsg fqsievstvt ssvlasesip sisdstfskf 781 hsisepvssa ivetatssfs ktetktsrvi afstedsers salidnseyt svladnlept 841 svladnsept svladssept svftdavqsp ktsvgqssls estniegtsm asmifsssga 901 sigalsdigk gtlsvesass tvaqpmpgvt ttapsfvssp hkisassida sgfvqkeimi 961 evqsskdsse afgvrhkise nvntpvsrml ttemqasgtv dvtedvslss evisalnvei 1021 tslpnpvapp qtiaaplnnn sntnivnddn avagtvnyag lhdel // LOCUS NP_009994 520 aa linear PLN 30-JUN-2025 DEFINITION triglyceride lipase ATG15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009994 VERSION NP_009994.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178779.1 REFERENCE 1 (residues 1 to 520) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 520) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 520) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 520) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07540. On Sep 29, 2000 this sequence version replaced NP_009994.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..520 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..520 /product="triglyceride lipase ATG15" /EC_number="3.1.1.3" /calculated_mol_wt="58304" Region 176..421 /region_name="Lipase_3" /note="Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; cd00519" /db_xref="CDD:238287" Site order(242..243,257..265) /site_type="active" /note="active site flap/lid [active]" /db_xref="CDD:238287" Site 330..334 /site_type="active" /note="nucleophilic elbow [active]" /db_xref="CDD:238287" CDS 1..520 /gene="ATG15" /locus_tag="YCR068W" /gene_synonym="AUT5; CVT17" /coded_by="NM_001178779.1:1..1563" /experiment="EXISTENCE:direct assay:GO:0004620 phospholipase activity [PMID:37917025|PMID:27543826]" /experiment="EXISTENCE:direct assay:GO:0005773 vacuole [PMID:37917025]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:37626866]" /experiment="EXISTENCE:direct assay:GO:0005775 vacuolar lumen [PMID:11566994]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:37626866|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006624 vacuolar protein processing [PMID:11085977]" /experiment="EXISTENCE:direct assay:GO:0006660 phosphatidylserine catabolic process [PMID:27543826]" /experiment="EXISTENCE:direct assay:GO:0006914 autophagy [PMID:11085977|PMID:11566994]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11085977]" /experiment="EXISTENCE:direct assay:GO:0030397 membrane disassembly [PMID:11085977]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:31332264]" /experiment="EXISTENCE:mutant phenotype:GO:0004620 phospholipase activity [PMID:27543826]" /experiment="EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:11085977]" /experiment="EXISTENCE:mutant phenotype:GO:0006660 phosphatidylserine catabolic process [PMID:27543826]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:11566994|PMID:11085977]" /experiment="EXISTENCE:mutant phenotype:GO:0030397 membrane disassembly [PMID:11085977]" /experiment="EXISTENCE:mutant phenotype:GO:0034496 multivesicular body membrane disassembly [PMID:12499386]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0046461 neutral lipid catabolic process [PMID:26061644]" /note="Phospholipase B; hydrolyses phosphatidylserine; minor activity against cardiolipin and PtdEtn; required for lysis of autophagic and CVT bodies; targeted to the vacuole via the Pep1p-dependent endosomal VPS pathway; targeted to intravacuolar vesicles during autophagy by the MVB pathway; maintains lipid droplet quantity after the diauxic shift; regulates lipolysis; single membrane spanning protein with cytosolic N-term and the rest in the ER lumen; expression regulated by Yap1p during autophagy" /db_xref="GeneID:850432" /db_xref="SGD:S000000664" ORIGIN 1 mlhkspsrkr fasplhlgci ltltvlclia yyfalpdyls vgksssrgam dqksdgtfrl 61 ksiyrhgvga nhrlhqrlev tpevisaagm lyqetttqgq dfedqeplwt tnaeyattnp 121 fdfefelrrm pllmkrmker dpefiesyiy getymteeee hamwidddiv apnitdrgtv 181 vslalmssna yvripqtgdw rnvtepwnet epedfgwdgd girghvfyne venivvlsik 241 gtsaqglpgs gedettgndk indnllfscc carvsylwtt vcdcyvksyi cdesclekel 301 rrkdrfysav vdiykgvlke ypdaaiwvtg hslggalasl lgrtfglpav afespgellp 361 skrlhlpfpp glpsymegiw hfghnadpif mgtcngasss cslvgyamet achtgrvcvy 421 dvvndkgwsv nmfnhrihkv idevllgyeq aakcvepepc vdcynwkfip srdwesssrl 481 itktkshaap ttttrttatt tssstcvgrn wlgfctkyel // LOCUS NP_009995 318 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase family protein CPR4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009995 VERSION NP_009995.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178780.1 REFERENCE 1 (residues 1 to 318) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 318) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 318) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 318) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07541. Method: conceptual translation. FEATURES Location/Qualifiers source 1..318 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..318 /product="peptidylprolyl isomerase family protein CPR4" /EC_number="5.2.1.8" /calculated_mol_wt="35649" Region 67..219 /region_name="cyclophilin" /note="cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug...; cd00317" /db_xref="CDD:238194" Site order(115,117,120..121,123,159..160,169,171,181..182,186) /site_type="active" /db_xref="CDD:238194" CDS 1..318 /gene="CPR4" /locus_tag="YCR069W" /gene_synonym="CYP4; SCC3; YCR070W" /coded_by="NM_001178780.1:1..957" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway; CPR4 has a paralog, CPR8, that arose from the whole genome duplication" /db_xref="GeneID:850433" /db_xref="SGD:S000000665" ORIGIN 1 mwlkslllcl yslvlcqvha apssgkqits kdvdlqkkye psppathrgi itieyfdpvs 61 ksmkeadltf elygtvvpkt vnnfamlahg vkaviegkdp ndihtysyrk tkinkvypnk 121 yiqggvvapd vgpftvygpk fddenfylkh drperlamay fgpdsntsef iittkadgne 181 eldgksvvfg qitsgldqlm daiqytetde ygkpqhelrf lyfvleilki snildlhaay 241 tekvekfrng dvsvgstlen ifrndkaytp lttstgttay dlnhpisral mcltvlglcf 301 iaykgmhekp htvslrhk // LOCUS NP_009996 146 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL49 IMG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009996 VERSION NP_009996.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178781.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 146) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07542. On Sep 29, 2000 this sequence version replaced NP_009996.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..146 /product="mitochondrial 54S ribosomal protein mL49 IMG2" /calculated_mol_wt="16249" Region 64..145 /region_name="Img2" /note="Mitochondrial large subunit ribosomal protein (Img2); pfam05046" /db_xref="CDD:461535" CDS 1..146 /gene="IMG2" /locus_tag="YCR071C" /gene_synonym="mL49" /coded_by="NM_001178781.1:1..441" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit; conserved in metazoa, with similarity to human mitochondrial ribosomal protein MRPL49" /db_xref="GeneID:850434" /db_xref="SGD:S000000667" ORIGIN 1 misscvtrcf grgkclpgpa tasiyqtirc istnsnkaae apifpkledv kmhelignnn 61 fgkktyyver srtgnlpvys ayknggnkii teirkiegdv iqlrndlqeq lpfipkksws 121 vvmqskkiii kgnaveavkr vltkkf // LOCUS NP_009997 515 aa linear PLN 30-JUN-2025 DEFINITION Rsa4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009997 VERSION NP_009997.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178782.1 REFERENCE 1 (residues 1 to 515) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 515) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 515) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 515) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07543. On Sep 29, 2000 this sequence version replaced NP_009997.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..515 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..515 /product="Rsa4p" /calculated_mol_wt="56895" Region 32..>79 /region_name="NLE" /note="NLE (NUC135) domain; pfam08154" /db_xref="CDD:462380" Region 141..513 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 189..227 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 233..276 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 281..316 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 324..399 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 405..441 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 447..483 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 489..513 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..515 /gene="RSA4" /locus_tag="YCR072C" /coded_by="NM_001178782.1:1..1548" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16221974]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:16221974]" /experiment="EXISTENCE:mutant phenotype:GO:0110136 protein-RNA complex remodeling [PMID:19737519]" /note="Ribosomal large subunit (60S) assembly factor; association of the N-terminal ubiquitin-like (UBL) domain of this preribosomal factor with the MIDAS domain in the Rea1p tail, promoted by the GTPase Nog2p, is required for the ATP-dependent dissociation of preribosomal factors including the Rix1p subcomplex, Rea1p, Nog2p and Rsa1p itself prior to nuclear export of pre-60S particles; contains WD-repeats and a UBL domain; localizes to the nucleolus" /db_xref="GeneID:850435" /db_xref="SGD:S000000668" ORIGIN 1 mstlipppsk kqkkeaqlpr evaiipkdlp nvsikfqald tgdnvggalr vpgaisekql 61 eellnqlngt sddpvpytfs ctiqgkkasd pvktiditdn lysslikpgy nstedqitll 121 ytpravfkvk pvtrsssaia ghgstilcsa faphtssrmv tgagdntari wdcdtqtpmh 181 tlkghynwvl cvswspdgev iatgsmdnti rlwdpksgqc lgdalrghsk witslswepi 241 hlvkpgskpr lassskdgti kiwdtvsrvc qytmsghtns vscvkwggqg llysgshdrt 301 vrvwdinsqg rcinilksha hwvnhlslst dyalrigafd htgkkpstpe eaqkkaleny 361 ekickkngns eemmvtasdd ytmflwnplk stkpiarmtg hqklvnhvaf spdgryivsa 421 sfdnsiklwd grdgkfistf rghvasvyqv awssdcrllv scskdttlkv wdvrtrklsv 481 dlpghkdevy tvdwsvdgkr vcsggkdkmv rlwth // LOCUS NP_009998 1331 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase kinase kinase SSK22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_009998 VERSION NP_009998.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178783.1 REFERENCE 1 (residues 1 to 1331) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1331) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1331) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1331) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07544. On Sep 29, 2000 this sequence version replaced NP_009998.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1331 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1331 /product="mitogen-activated protein kinase kinase kinase SSK22" /EC_number="2.7.11.1" /calculated_mol_wt="152587" Region 1033..1309 /region_name="STKc_MEKK4" /note="Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4; cd06626" /db_xref="CDD:270796" Site order(1040..1044,1048,1061,1063,1096,1112..1115,1118..1119, 1122,1158,1160..1163,1165,1175..1176,1179,1209..1212,1214, 1244,1253) /site_type="active" /db_xref="CDD:270796" Site order(1040..1044,1048,1061,1063,1096,1112..1115,1117..1119, 1122,1162..1163,1165,1175..1177) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270796" Site order(1043..1044,1158,1160..1162,1179,1209..1212,1214,1244, 1253) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270796" Site order(1175..1180,1182..1185,1208..1214) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270796" CDS 1..1331 /gene="SSK22" /locus_tag="YCR073C" /coded_by="NM_001178783.1:1..3996" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:genetic interaction:GO:0038066 p38MAPK cascade [PMID:7624781|PMID:9742096]" /experiment="EXISTENCE:mutant phenotype:GO:0038066 p38MAPK cascade [PMID:7624781]" /note="MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication" /db_xref="GeneID:850436" /db_xref="SGD:S000000669" ORIGIN 1 mmmdilntqq qkaaeggrvl aphtissklv krlsshsshk lsrsdlkalg gsetisdgps 61 qltfkdryvf neslylkklk ktalddyytr gikltnryee ddgddeiirl sngdridedl 121 hsgvkffstt pycrkmrsds delawneiat erfkwqsmla rvlkgdivkg ektrianqvk 181 kpglnkelsd eiwlelkawl ngrtmqemeq sltylrdssd svfeeimkfq ipqgkilsld 241 aleailqdlm nryhsvvsyw pnlkkmykdk pitntaefta ridvmnswln fktnltlrrq 301 elddwinrfs pisssdncqe dfdgvpqwnc kmkilaeqlm kekniesifq kkifyplspw 361 mfklklhfiv yretltkmni kypyerlrsl lafpvylike viltrlsyar klknptmmmi 421 dqmiddfnaf irlsvqlkyt ltkycsnlpf dvdfdptfen tvieairylf fllnlklids 481 skqnfkapdl llkywdhlkn tghyingaet vipneflklt lrlvhklqfy llkqqnfppt 541 fanaseaekw lssifenlga mkrklnrfsn ilvkafqnsa vyqinhnaql vkklkdahyf 601 lvysgntfes sgvymfaape llgcdndtil rilrnksigc dlvpkldign nlnvydittk 661 etdlnilvsk gedskgipyy rvvansssdl drhahqskkk nfstdpfdqh ldeknnevfe 721 levalsslga lvvlypgepv vwdgpvyklp gnnlfasnem dlgkignpnt lillnqgsny 781 altyqidkfn qtvgdsvsfi ekrcslnsie sslqkinkay ykltytvlnn ykgilgsfmk 841 qcpgnellns ifmfgrdfgr sflkynafss krkyviiflm vklgmnwlkf lveecdptdq 901 rtfrwcvlam dfamqmtsgy nilalnvkqf qelkervsvc msllishfdv mgarateaen 961 gmqqarlnid teenideeat leinsrlrle aiktlektmk rnprqmgkvl datdqgnkyl 1021 lslasslsnv smrwqkrsfi gggtfgqvys ainlengeil avkeikihdt ttmkkifpli 1081 keemtvleml nhpnivqyyg vevhrdkvni fmeyceggsl aslldhgrie demvtqvytf 1141 elleglaylh qsgvvhrdik penilldfng iikyvdfgta rtvvgsrtrt vrnaavqdfg 1201 vetkslnemm gtpmymapet isgsavkgkl gaddvwalgc vvlematgrr pwsnldnewa 1261 imyhvaagri pqlpnrdemt aagraflerc lvqdptmrat avellidpwm iqireiafgn 1321 sekdqvpils s // LOCUS NP_009999 315 aa linear PLN 30-JUN-2025 DEFINITION Sol2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_009999 VERSION NP_009999.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178815.1 REFERENCE 1 (residues 1 to 315) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 315) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 315) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 315) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07545. On Sep 29, 2000 this sequence version replaced NP_009999.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..315 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..315 /product="Sol2p" /calculated_mol_wt="34370" Region 87..292 /region_name="6PGL" /note="6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the...; cd01400" /db_xref="CDD:238694" Site order(96..97,124,205,237,260) /site_type="active" /note="putative active site [active]" /db_xref="CDD:238694" CDS 1..315 /gene="SOL2" /locus_tag="YCR073W-A" /gene_synonym="YCRX13W" /coded_by="NM_001178815.1:1..948" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15454531]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:15454531]" /note="Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication" /db_xref="GeneID:850437" /db_xref="SGD:S000000718" ORIGIN 1 mtttvpkifa fhefsdvaea vadhvvhaqd galapknerk hsvpnismna ldmtreasck 61 stasaaegks gssgsgsgss kpkkekrfki alsggsliev lhegllkrdd vrwgdwdiyf 121 aderlvpfss nesnygcakr kildlidtak ygtpkvyhid esliddpqec adnyekvlir 181 gfagrdsvkl pmfdlfllgc apdghiaslf pnfqdnlrek lawvvpvena psgpstrisl 241 tipvichshr vtfvvegatk apiiktimer pekglpssiv negaagrvsw fvdddaltdv 301 lvtkkkykfh qglsi // LOCUS NP_010000 260 aa linear PLN 30-JUN-2025 DEFINITION cystinosin-like protein ERS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010000 VERSION NP_010000.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178784.1 REFERENCE 1 (residues 1 to 260) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 260) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 260) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 260) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07546. Method: conceptual translation. FEATURES Location/Qualifiers source 1..260 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..260 /product="cystinosin-like protein ERS1" /calculated_mol_wt="29985" Region 2..248 /region_name="2A43" /note="Lysosomal Cystine Transporter; TIGR00951" /db_xref="CDD:130026" CDS 1..260 /gene="ERS1" /locus_tag="YCR075C" /coded_by="NM_001178784.1:1..783" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:15885099|PMID:27142334]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:15885099]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27142334]" /experiment="EXISTENCE:direct assay:GO:0015811 L-cystine transport [PMID:27142334]" /experiment="EXISTENCE:genetic interaction:GO:0015184 L-cystine transmembrane transporter activity [PMID:15885099]" /experiment="EXISTENCE:genetic interaction:GO:0015811 L-cystine transport [PMID:15885099]" /note="Protein involved in cystine transport; localizes to the vacuole, plasma membrane and endosome; similarity to human cystinosin, a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains; mutation is functionally complemented by human CTNS" /db_xref="GeneID:850438" /db_xref="SGD:S000000671" ORIGIN 1 mvslddilgi vyvtswsism yppiitnwrh ksasaismdf vmlntagysy lvisiflqly 61 cwkmtgdesd lgrpkltqfd fwyclhgclm nvvlltqvva gariwrfpgk ghrkmnpwyl 121 rillaslaif slltvqfmys nywydwhnsr tlaycnnlfl lkismsliky ipqvthnstr 181 ksmdcfpiqg vfldvtggia sllqliwqls ndqgfsldtf vtnfgkvgls mvtlifnfif 241 imqwfvyrsr ghdlaseypl // LOCUS NP_878058 75 aa linear PLN 30-JUN-2025 DEFINITION Ego2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878058 VERSION NP_878058.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184529.1 REFERENCE 1 (residues 1 to 75) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 75) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 75) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 75) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07547. Method: conceptual translation. FEATURES Location/Qualifiers source 1..75 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..75 /product="Ego2p" /calculated_mol_wt="7966" Region 3..73 /region_name="DUF3215" /note="Protein of unknown function (DUF3215); pfam11503" /db_xref="CDD:371567" CDS 1..75 /gene="EGO2" /locus_tag="YCR075W-A" /coded_by="NM_001184529.1:1..228" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26206314]" /experiment="EXISTENCE:mutant phenotype:GO:0038202 TORC1 signaling [PMID:26206314]" /experiment="EXISTENCE:mutant phenotype:GO:0072665 protein localization to vacuole [PMID:26206314]" /experiment="EXISTENCE:physical interaction:GO:0071986 Ragulator complex [PMID:26206314]" /note="Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; identified by homology to Ashbya gossypii; EGO2 has a paralog, EGO4, that arose from the whole genome duplication" /db_xref="GeneID:1466399" /db_xref="SGD:S000028519" ORIGIN 1 meaekqsdik gtiafdthgn viestgvgsq riedigdlsk vtldaegfaq vqgdsllvhl 61 ykrnditlav ytsaq // LOCUS NP_010001 250 aa linear PLN 30-JUN-2025 DEFINITION Fub1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010001 VERSION NP_010001.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178785.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 250) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07548. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..250 /product="Fub1p" /calculated_mol_wt="26625" CDS 1..250 /gene="FUB1" /locus_tag="YCR076C" /coded_by="NM_001178785.1:1..753" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:22362029]" /note="Proteasome-binding protein; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; specifically blocks all three proteasome active sites; exhibits boundary activity which inhibits the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene" /db_xref="GeneID:850439" /db_xref="SGD:S000000672" ORIGIN 1 mienkvelva elvlesigkt evvsrhtegt kscqvsfrik dspsekgsts flselvviqt 61 lddndkytvv irhgtsitma cvvgysdfkl ptelkwpler eslpvepdlk pimtqlkrqt 121 agsadmpkfd deyqaqarqn qgtaplnpyp gltvtepsfa npaggyadgd lypvgtshpd 181 wsgglpnplg npssqggmif dpnrrpaprr edmppgwmpg skydepfgpg sggfggsgsg 241 gfggsgsgfi // LOCUS NP_010002 796 aa linear PLN 30-JUN-2025 DEFINITION deadenylation-dependent mRNA-decapping factor PAT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010002 VERSION NP_010002.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178786.2 REFERENCE 1 (residues 1 to 796) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 796) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 796) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 796) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07549. On Apr 26, 2011 this sequence version replaced NP_010002.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..796 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..796 /product="deadenylation-dependent mRNA-decapping factor PAT1" /calculated_mol_wt="88381" Region 1..785 /region_name="PAT1" /note="Topoisomerase II-associated protein PAT1; pfam09770" /db_xref="CDD:401645" CDS 1..796 /gene="PAT1" /locus_tag="YCR077C" /gene_synonym="MRT1" /coded_by="NM_001178786.2:1..2391" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:23893485]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:12730603]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:25035297]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23706738|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:10779343]" /experiment="EXISTENCE:direct assay:GO:0045947 negative regulation of translational initiation [PMID:20832728]" /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]" /experiment="EXISTENCE:genetic interaction:GO:0033962 P-body assembly [PMID:18981231]" /experiment="EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:10913177]" /experiment="EXISTENCE:mutant phenotype:GO:0000932 P-body [PMID:12730603]" /experiment="EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:20832728]" /experiment="EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:10779343]" /experiment="EXISTENCE:mutant phenotype:GO:0033962 P-body assembly [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0045947 negative regulation of translational initiation [PMID:20832728]" /experiment="EXISTENCE:physical interaction:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:10913177]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:26952104]" /note="Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; binds to mRNAs under glucose starvation, most often in the 3' UTR; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress; phosphorylation by PKA inhibits P body foci formation" /db_xref="GeneID:850440" /db_xref="SGD:S000000673" ORIGIN 1 msffglensg nardgpldfe esykgygehe leendylnde tfgdnvqvgt dfdfgnphss 61 gssgnaiggn gvgatarsyv aataegisgp rtdgtaaagp ldlkpmeslw stapppamap 121 spqstmapap apqqmaplqp ilsmqdlerq qrqmqqqfmn fhamghpqgl pqgppqqqfp 181 mqpasgqpgp sqfapppppp gvnvnmnqmp mgpvqvpvqa spspigmsnt pspgpvvgat 241 kmplqsgrrs krdlspeeqr rlqirhakve kilkysglmt prdkdfitry qlsqivtedp 301 ynedfyfqvy kiiqrggits esnkgliara ylehsghrlg grykrtdial qrmqsqveka 361 vtvakerpsk lkdqqaaagn ssqdnkqant vlgkisstln sknprrqlqi prqqpsdpda 421 lkdvtdsltn vdlassgsss tgssaaavas kqrrrssyaf nngngatnln ksggkkfile 481 lietvyeeil dleanlrngq qtdstamwea lhiddssydv npfismlsfd kgikimprif 541 nfldkqqklk ilqkifnels hlqiiilssy kttpkptltq lkkvdlfqmi ilkiivsfls 601 nnsnfieimg lllqlirnnn vsflttskig lnlitilisr aalikqdssr snilsspeis 661 twneiydklf tsleskiqli fppreyndhi mrlqndkfmd eayiwqflas lalsgklnhq 721 riiidevrde ifatineaet lqkkekelsv lpqrsqeldt elksiiynke klyqdlnlfl 781 nvmglvyrdg eiselk // LOCUS NP_010003 442 aa linear PLN 30-JUN-2025 DEFINITION type 2C protein phosphatase PTC6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010003 VERSION NP_010003.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180034.1 REFERENCE 1 (residues 1 to 442) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 442) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 442) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 442) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07550. On Sep 29, 2000 this sequence version replaced NP_010003.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..442 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..442 /product="type 2C protein phosphatase PTC6" /EC_number="3.1.3.16" /EC_number="3.1.3.43" /calculated_mol_wt="49290" Site order(39,43..44,68..70,353,402) /site_type="active" /db_xref="CDD:238083" Region 108..401 /region_name="PP2C" /note="Protein phosphatase 2C; pfam00481" /db_xref="CDD:395385" CDS 1..442 /gene="PTC6" /locus_tag="YCR079W" /gene_synonym="AUP1; PPP2" /coded_by="NM_001180034.1:1..1329" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:17002782]" /experiment="EXISTENCE:direct assay:GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity [PMID:28539364]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:17166847]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:18180296]" /experiment="EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:17166847]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:17166847]" /experiment="EXISTENCE:mutant phenotype:GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity [PMID:18180296]" /experiment="EXISTENCE:mutant phenotype:GO:1901524 regulation of mitophagy [PMID:31548421]" /note="Mitochondrial type 2C protein phosphatase (PP2C); has similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase" /db_xref="GeneID:850441" /db_xref="SGD:S000002133" ORIGIN 1 mrlgnayayc kpsqnvglkl dllrglpgyv ghatsrinrl enqdnysikm mrswpnaygs 61 alncsvfdgh gekgaqlsql ladklcssld fpepswdkqd lkklvqeyar rfpegnywkh 121 klstfekfyn kfikncnskq elllmkegds ailgqnggrm ifdkmgniid kiallteldr 181 lrlfygfarf dldqccglgt aagstassif lypyddpnap idegkdddsw iishsgllkl 241 ivtqvgdski ilcdqdgiah alttthhins srerhrlsid psrldpdafg etrflnnfan 301 trsfgdvagk pygissepdi fsflvgntlh lprsersklp fngdecflal vtdgitnkla 361 dqevvdlits tvnswglkka tpqfvaeeti kfiqaiatkh sdnatcvvvr lsnwgnwpnv 421 drtgpqretk lmnaqsnetk ln // LOCUS NP_010004 1427 aa linear PLN 30-JUN-2025 DEFINITION Srb8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010004 VERSION NP_010004.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178787.1 REFERENCE 1 (residues 1 to 1427) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1427) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1427) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1427) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07551. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1427 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1427 /product="Srb8p" /calculated_mol_wt="166730" Region 113..175 /region_name="Med12" /note="Transcription mediator complex subunit Med12; pfam09497" /db_xref="CDD:462818" CDS 1..1427 /gene="SRB8" /locus_tag="YCR081W" /gene_synonym="GIG1; MED12; NUT6; SSN5; YCR080W" /coded_by="NM_001178787.1:1..4284" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:20505076]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:12200444|PMID:11383511]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16109375]" /experiment="EXISTENCE:mutant phenotype:GO:0000411 positive regulation of transcription by galactose [PMID:15601835]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:20505076]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15601835]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression" /db_xref="GeneID:850442" /db_xref="SGD:S000000677" ORIGIN 1 mnngsgryll tppddlhpyv psskpqeqvy pdfkpwehta aedqilanfv akgfyhtpmv 61 nfesisarss vheslvtqsn ilsqqfdkii kiredhinki psnstttlhg pgfqlpnrit 121 ltdhrketwl helssshtsl vkigkfiphg lkrrqvieqc ylkfiplkra iwlikccyfi 181 ewksnhkkkr snaagaddai smhllkdwtd tfvyilekli fdmtnhynds qqlrtwkrqi 241 syflkllgnc yslrlinkei fhhwlvefin kmenfeflpl slhilmifwn dicqidtnap 301 vaatitssqk epfflvtkit dmllhkyyiv sssksminde nyiindikkn nkiklnilki 361 lsslilkifq eqslevfifp tsnweiykpl lfeivsnadt nqnsdmkkkl elisyrnesl 421 knnssirnvi msasnandfq ltivtckqfp klsciqlnci dtqftklldd nptefdwpty 481 vdqnpltmhk iiqlilwsih psrqfdhyes nqlvakllll rinstdedlh efqiedaiws 541 lvfqlaknfs aqkrvvsymm pslyrllnil itygiikvpt yirklissgl lylqdsndkf 601 vhvqllinlk isplmksqyn mvlrnvmeyd vkfyeifnfd qlveiteqik mrilsnditn 661 lqlsktplsi kimvaewyls hlcsgilssv nrtvllkifk ifcidlevfh hffkwiefiv 721 yhqllsdies lealmdillc yqklfsqfin dhilftktfi fiykkvlkek dvpaynvtsf 781 mpfwkffmkn fpfvlkvdnd lrielqsvyn deklkteklk ndksevlkvy sminnsnqav 841 gqtwnfpevf qvnirfllhn seiidtntsk qfqkarnnvm lliatnlkey nkfmsiflkr 901 kdftnknliq lislklltfe vtqnvlgley iirllpinle nndgsyglfl kyhkeqfiks 961 nfekilltcy elekkyhgne ceinyyeill kilitygssp kllatstkii mlllndsven 1021 ssniledily ystcpsetdl ndiplgsgqp dndtvvtndd ksddddhtvd eidhveyyvm 1081 mdfanlwvfq aftcfcikki mennepamam edlknfifqi ieitnsndlc sqifdqlkdm 1141 qtiemitqiv ekdfctsclq nnnqkiddny ivvvieiits lsmrfqrets gmivismeny 1201 hllikiirql selnegnlsk reiqidavlk ifsfhqdsif qriiadlsad kptspfidsi 1261 cklfdkisfn lrlklflyei lsslksfaiy sstidapafh tsgkvelpkk llnlppfqvs 1321 sfvketklhs gdygeeedad qeesfslnlg igiveiahen eqkwliydkk dhkyvctfsm 1381 epyhfisnyn tkytddmatg sndttafnds cvnlslfdar ferknph // LOCUS NP_010005 128 aa linear PLN 30-JUN-2025 DEFINITION Ahc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010005 VERSION NP_010005.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178788.1 REFERENCE 1 (residues 1 to 128) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 128) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 128) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 128) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07552. Method: conceptual translation. FEATURES Location/Qualifiers source 1..128 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..128 /product="Ahc2p" /calculated_mol_wt="14986" CDS 1..128 /gene="AHC2" /locus_tag="YCR082W" /coded_by="NM_001178788.1:1..387" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16464826]" /experiment="EXISTENCE:direct assay:GO:0140110 transcription regulator activity [PMID:16464826]" /experiment="EXISTENCE:mutant phenotype:GO:0140671 ADA complex [PMID:21734642]" /experiment="EXISTENCE:physical interaction:GO:0140671 ADA complex [PMID:21734642]" /note="Component of the ADA histone acetyltransferase complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ahc1p to the complex" /db_xref="GeneID:850443" /db_xref="SGD:S000000678" ORIGIN 1 mitpkgthda vakfqktdlh qdldyivlqq rrtqletlin eresfvknlc slfhkiqntk 61 nyqefvdvla enrdllreif tvengfqkqk wisnddipqi dwdkfaldin ayiaendqll 121 alyedgll // LOCUS NP_010006 127 aa linear PLN 30-JUN-2025 DEFINITION Trx3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010006 VERSION NP_010006.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178789.1 REFERENCE 1 (residues 1 to 127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 127) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07553. Method: conceptual translation. FEATURES Location/Qualifiers source 1..127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..127 /product="Trx3p" /calculated_mol_wt="14301" Region 35..125 /region_name="TRX_family" /note="TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; cd02947" /db_xref="CDD:239245" Site order(55,58) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239245" CDS 1..127 /gene="TRX3" /locus_tag="YCR083W" /coded_by="NM_001178789.1:1..384" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:10037727]" /experiment="EXISTENCE:direct assay:GO:0015036 disulfide oxidoreductase activity [PMID:10037727]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10037727]" /note="Mitochondrial thioredoxin; highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p" /db_xref="GeneID:850444" /db_xref="SGD:S000000679" ORIGIN 1 mlfykpvmrm avrplksirf qssytsitkl tnltefrnli kqndklvidf yatwcgpckm 61 mqphltkliq aypdvrfvkc dvdespdiak ecevtamptf vlgkdgqlig kiiganptal 121 ekgikdl // LOCUS NP_010007 713 aa linear PLN 30-JUN-2025 DEFINITION chromatin-silencing transcriptional regulator TUP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010007 VERSION NP_010007.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178790.1 REFERENCE 1 (residues 1 to 713) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 713) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 713) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 713) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07554. Method: conceptual translation. FEATURES Location/Qualifiers source 1..713 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..713 /product="chromatin-silencing transcriptional regulator TUP1" /calculated_mol_wt="78177" Region 11..88 /region_name="Tup_N" /note="Tup N-terminal; pfam08581" /db_xref="CDD:400755" Region 343..706 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(343,361,364,370..371,389..390,460,464,470..471, 483..484,501,506,512..513,525,543,548,554..555,574..575, 593,597,603..604,628..629,646,651,657..658,670..671,695, 699,705..706) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 347..383 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 394..438 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 447..483 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 488..523 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 530..566 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 579..627 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 633..669 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 675..705 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..713 /gene="TUP1" /locus_tag="YCR084C" /gene_synonym="AAR1; AER2; AMM1; CRT4; CYC9; FLK1; ROX4; SFL2; UMR7" /coded_by="NM_001178790.1:1..2142" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9741624]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1739976]" /experiment="EXISTENCE:direct assay:GO:0036033 mediator complex binding [PMID:11226276]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:8675011]" /experiment="EXISTENCE:direct assay:GO:0042826 histone deacetylase binding [PMID:14525981]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:21536737]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18708352|PMID:9461460|PMID:1900249|PMID:1312982|PMID :9858577|PMID:9560430]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:9560430]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:9741624]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9280286]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:9741624]" /experiment="EXISTENCE:mutant phenotype:GO:0042304 regulation of fatty acid biosynthetic process [PMID:9280286]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:26546823]" /experiment="EXISTENCE:mutant phenotype:GO:2000879 negative regulation of dipeptide transport [PMID:18708352]" /experiment="EXISTENCE:physical interaction:GO:0017053 transcription repressor complex [PMID:9111019]" /experiment="EXISTENCE:physical interaction:GO:0036033 mediator complex binding [PMID:11226276]" /experiment="EXISTENCE:physical interaction:GO:0042826 histone deacetylase binding [PMID:14525981]" /note="Transcriptional regulator; functions primarily as a transcriptional co-repressor with Cyc8p but can also function as a co-activator, recruiting SWI/SNF and SAGA complexes to promoters; target genes may be uniquely repressed by Tup1p or Cyc8p, subject to redundant repression, or in some cases de-repression of target genes in a tup1 mutant is dependent upon CYC8 and vice versa; establishes a repressive chromatin structure via histone H3/H4 interactions and stabilizing nucleosomes over promoters" /db_xref="GeneID:850445" /db_xref="SGD:S000000680" ORIGIN 1 mtasvsntqn klnelldair qeflqvsqea ntyrlqnqkd ydfkmnqqla emqqirntvy 61 elelthrkmk dayeeeikhl klgleqrdhq iasltvqqqr qqqqqqqvqq hlqqqqqqla 121 aasasvpvaq qppattsata tpaantttgs psafpvqasr pnlvgsqlpt ttlpvvssna 181 qqqlpqqqlq qqqlqqqqpp pqvsvaplsn taingsptsk etttlpsvka pestlketep 241 ennntskind tgsattattt tateteikpk eedatpaslh qdhylvpynq ranhskpipp 301 flldldsqsv pdalkkqtnd yyilynpalp reidvelhks ldhtsvvccv kfsndgeyla 361 tgcnkttqvy rvsdgslvar lsddsaannh rnsitenntt tstdnntmtt tttttittta 421 mtsaaelakd venlntsssp ssdlyirsvc fspdgkflat gaedrliriw dienrkivmi 481 lqgheqdiys ldyfpsgdkl vsgsgdrtvr iwdlrtgqcs ltlsiedgvt tvavspgdgk 541 yiaagsldra vrvwdsetgf lverldsene sgtghkdsvy svvftrdgqs vvsgsldrsv 601 klwnlqnann ksdsktpnsg tcevtyighk dfvlsvattq ndeyilsgsk drgvlfwdkk 661 sgnpllmlqg hrnsvisvav angsplgpey nvfatgsgdc kariwkykki apn // LOCUS NP_001335752 117 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR085W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335752 VERSION NP_001335752.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348897.1 REFERENCE 1 (residues 1 to 117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 117) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80272. Method: conceptual translation. FEATURES Location/Qualifiers source 1..117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..117 /product="uncharacterized protein" /calculated_mol_wt="13372" CDS 1..117 /locus_tag="YCR085W" /coded_by="NM_001348897.1:1..354" /note="hypothetical protein; conserved among S. cerevisiae strains; YCR085W is not an essential gene" /db_xref="GeneID:850446" /db_xref="SGD:S000000681" ORIGIN 1 mlflytyvyv flctnndvyn etsvmlskts ahcfiaeevt tdnglicgla mlgktkyqfy 61 elftvysiqs ltqlasrvkk gglimarlil ftlcalpvlf hfilfmlqyl vfvyiek // LOCUS NP_010009 190 aa linear PLN 30-JUN-2025 DEFINITION Csm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010009 VERSION NP_010009.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178792.1 REFERENCE 1 (residues 1 to 190) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 190) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 190) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 190) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07555. Method: conceptual translation. FEATURES Location/Qualifiers source 1..190 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..190 /product="Csm1p" /calculated_mol_wt="21620" Region 1..70 /region_name="Csm1_N" /note="Csm1 N-terminal domain; pfam18504" /db_xref="CDD:375930" Region 72..165 /region_name="Csm1" /note="Chromosome segregation protein Csm1/Pcs1; pfam12539" /db_xref="CDD:432621" CDS 1..190 /gene="CSM1" /locus_tag="YCR086W" /coded_by="NM_001178792.1:1..573" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11489916]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12689592]" /experiment="EXISTENCE:direct assay:GO:0033551 monopolin complex [PMID:12689592]" /experiment="EXISTENCE:genetic interaction:GO:0051455 spindle attachment to meiosis I kinetochore [PMID:12689592]" /experiment="EXISTENCE:mutant phenotype:GO:0034503 protein localization to nucleolar rDNA repeats [PMID:19362534]" /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0045143 homologous chromosome segregation [PMID:12689592]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:18923139]" /experiment="EXISTENCE:physical interaction:GO:0045143 homologous chromosome segregation [PMID:12689592]" /note="Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation" /db_xref="GeneID:850447" /db_xref="SGD:S000000682" ORIGIN 1 mdpltvykns vkqqidsadl lvanlvnenf vlsekldtka teikqlqkqi dslnaqvkel 61 ktqtsqqaen sevikdlyey lcnvrvhksy eddsglwfdi sqgthsggss ddysimdykl 121 gfvkgqaqvt eviyapvlkq rsteelyslq sklpeylfet lsfplsslnq fynkiaksln 181 kkrekkdete // LOCUS NP_010011 153 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR087C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010011 VERSION NP_010011.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184316.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 153) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07556. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..153 /product="uncharacterized protein" /calculated_mol_wt="17607" Region 30..58 /region_name="zf-LYAR" /note="LYAR-type C2HC zinc finger; pfam08790" /db_xref="CDD:462605" CDS 1..153 /locus_tag="YCR087C-A" /coded_by="NM_001184316.1:1..462" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /note="hypothetical protein; binds zinc; phosphomutants exhibit phenotypes, suggesting functionality of phosphosites; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene" /db_xref="GeneID:850449" /db_xref="SGD:S000007223" ORIGIN 1 mvtfncevcn dtvpkkntek hyyrcpnayy tcidcsktfe dgvsyknhts cisedekyqk 61 alykgnkkqk qkqqqkqqqk qhqhqpvatp akkvekpvik kaekvektsn gielhkgksl 121 ykilktmkdk gakktflksl vvdsegqiry ake // LOCUS NP_010012 592 aa linear PLN 30-JUN-2025 DEFINITION Abp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010012 VERSION NP_010012.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178794.1 REFERENCE 1 (residues 1 to 592) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 592) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 592) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 592) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07557. Method: conceptual translation. FEATURES Location/Qualifiers source 1..592 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..592 /product="Abp1p" /calculated_mol_wt="65445" Region 6..141 /region_name="ADF_drebrin_like" /note="ADF homology domain of drebrin and actin-binding protein 1 (abp1); cd11281" /db_xref="CDD:200437" Site order(80,94,122,125) /site_type="other" /note="putative F-actin interface [polypeptide binding]" /db_xref="CDD:200437" Region <148..404 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" Region 536..590 /region_name="SH3_Abp1_fungi_C2" /note="Second C-terminal Src homology 3 domain of Fungal Actin-binding protein 1; cd11961" /db_xref="CDD:212894" Site order(541..544,546..550,555,565..566,568..569,582,584, 586..587) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212894" CDS 1..592 /gene="ABP1" /locus_tag="YCR088W" /coded_by="NM_001178794.1:1..1779" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11950888]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:8163554|PMID:16824951|PMID:3060468]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:3060468]" /experiment="EXISTENCE:direct assay:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:16824951]" /experiment="EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:18177206]" /experiment="EXISTENCE:mutant phenotype:GO:0044379 protein localization to actin cortical patch [PMID:11668184|PMID:15798181|PMID:10087264]" /experiment="EXISTENCE:mutant phenotype:GO:0051016 barbed-end actin filament capping [PMID:23333351]" /note="Actin-binding protein of the cortical actin cytoskeleton; important for activation of actin nucleation mediated by the Arp2/Arp3 complex; inhibits actin filament elongation at the barbed-end; phosphorylation within its proline-rich region, mediated by Cdc28p and Pho85p, protects Abp1p from PEST sequence-mediated proteolysis; mammalian homolog of HIP-55 (hematopoietic progenitor kinase 1 [HPK1]-interacting protein of 55 kDa)" /db_xref="GeneID:850450" /db_xref="SGD:S000000684" ORIGIN 1 malepidytt hsreidaeyl kivrgsdpdt twliispnak keyepestgs sfhdflqlfd 61 etkvqyglar vsppgsdvek iiiigwcpds aplktrasfa anfaavannl fkgyhvqvta 121 rdeddldene llmkisnaag arysiqtssk qqgkastppv kksftpsksp apvskkepvk 181 tpspapaaki ssrvndnndd ddwnepelke rdfdqaplkp nqssykpigk idlqkviaee 241 kakedprlvq kptaagskid pssdianlkn esklkrdsef nsflgttkpp smtesslknd 301 ddkvikgfrn ekspaqlwae rkakqnsgna etkaeapkpe vpedepegep dvkdlkskfe 361 glaasekeee emenkfappp kkseptiisp kpfskpqepv kaeeaeqpkt dykkignplp 421 gmhieadnee epeendddwd ddedeaaqpp lpsrnvasga pvqkeepeqe eiapslpsrn 481 sipapkqeea peqapeeeie eeaeeaapql psrssaappp pprratpekk pkenpwatae 541 ydydaaedne ltfvendkii niefvdddww lgelekdgsk glfpsnyvsl gn // LOCUS NP_010013 1609 aa linear PLN 30-JUN-2025 DEFINITION Fig2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010013 VERSION NP_010013.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178795.1 REFERENCE 1 (residues 1 to 1609) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1609) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1609) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1609) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07558. On Sep 29, 2000 this sequence version replaced NP_010013.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1609 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1609 /product="Fig2p" /calculated_mol_wt="165906" Region <347..1191 /region_name="FhaB" /note="Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]; COG3210" /db_xref="CDD:442443" CDS 1..1609 /gene="FIG2" /locus_tag="YCR089W" /coded_by="NM_001178795.1:1..4830" /experiment="EXISTENCE:direct assay:GO:0005937 mating projection [PMID:11027318]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9456310]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:9456310]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:9456310]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:11027318]" /experiment="EXISTENCE:mutant phenotype:GO:0044182 filamentous growth of a population of unicellular organisms [PMID:11027318]" /note="Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating; FIG2 has a paralog, AGA1, that arose from the whole genome duplication" /db_xref="GeneID:850451" /db_xref="SGD:S000000685" ORIGIN 1 mnsfaslgli ysvvnlltrv eaqivfyqns stslpvptlv stsiadfhes sstgevqyss 61 sysyvqpsid sftsssflts feaptetsss yavssslits dtfssysdif deetsslist 121 saassekass tlsstaqphr tshssssfel pvtapssssl psstsltfts vnpsqswtsf 181 nsekssalss tidftsseis gstspksles fdttgtitss yspspsskns nqtsllsple 241 plssssgdli lsstiqattn dqtsktiptl vdatsslppt lrsssmapts gsdsishnft 301 sppsktsgny dvltsnsidp slftttseys stqlsslnra sksetvnfta siastpfgtd 361 satslidpis svgstassfv gistanfstq gnsnyvpest asgssqyqdw sssslplsqt 421 twvvinttnt qgsvtsttsp ayvstatktv dgviteyvtw cpltqtksqa igvsssissv 481 pqassfsgss ilssnsstla asnnvpesta sgssqyqdws ssslplsqtt wvvinttntq 541 gsvtsttspa yvstatktvd gviteyvtwc pltqtksqai gissstisat qtskpssilt 601 lgistlqlsd atfkgtetin thlmtestsi teptyfsgts dsfylctsev nlasslssyp 661 nfsssegsta titnstvtfg stskypstsv snpteasqhv sssvnsltdf tsnstetiav 721 isnihktssn kdysltttql ktsgmqtlvl stvtttvnga ateyttwcpa ssiayttsis 781 yktlvlttev cshsectptv itsvtatsst ipllstssst vlsstvsega knpaasevti 841 ntqvsatsea tststqvsat satatasess ttsqvstase tistlgtqnf tttgsllfpa 901 lsteminttv vsrktliist evcshskcvp tvitevvtsk gtpsnghssq tlqteavevt 961 lsshqtvtms tevcsnsict ptvitsvqmr stpfpyltss tsssslastk kssleassem 1021 stfsvstqsl plaftssekr sttsvsqwsn tvltntimss ssnvistnek pssttspynf 1081 ssgyslpsss tpsqyslsta tttingiktv yttwcplaek stvaassqss rsvdrfvsss 1141 kpssslsqts iqytlstatt tisglktvyt twcpltskst lgattqtsst akvritsass 1201 atstsislst stesesssgy lskgvcsgte ctqdvptqss spastlaysp svstsssssf 1261 stttastlts thtsvpllps sssisassps stsllstslp spaftsstlp tatavssstf 1321 iasslplssk sslslspvss silmsqfsss sssssslasl pslsisptvd tvsvlqptts 1381 iatltctdsq cqqevsticn gsncddvtst attppstvtd tmtctgsecq kttssscdgy 1441 sckvsetyks satisacsge gcqasatsel nsqyvtmtsv itpsaittts vevhstesti 1501 sittvkpvty tssdtngeli titsssqtvi psvttiitrt kvaitsapkp ttttyveqrl 1561 sssgiatsfv aaasstwitt pivstyagsa skflcskffm imvmvinfi // LOCUS NP_010014 182 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR090C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010014 VERSION NP_010014.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178796.1 REFERENCE 1 (residues 1 to 182) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 182) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 182) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 182) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07559. Method: conceptual translation. FEATURES Location/Qualifiers source 1..182 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..182 /product="uncharacterized protein" /calculated_mol_wt="20572" Region 5..178 /region_name="CXXC_Zn-b_euk" /note="CXXC motif containing zinc binding protein, eukaryotic; pfam05907" /db_xref="CDD:461777" CDS 1..182 /locus_tag="YCR090C" /coded_by="NM_001178796.1:1..549" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene" /db_xref="GeneID:850452" /db_xref="SGD:S000000686" ORIGIN 1 mplflvlkat lsenvtkvsi entnesraef afdlqctscr elhdskviin tfeeyampas 61 kgtasflmkc kfcskelsvn lcafedeylt dqsddkwaki kdvrkkhgls kvkedsfipl 121 sldcrgceli kfypdtitfe vslssgkvms cqlednewyd yddnlgeevt mtdfsssiik 181 gk // LOCUS NP_010015 720 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase KIN82 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010015 VERSION NP_010015.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178797.2 REFERENCE 1 (residues 1 to 720) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 720) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 720) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 720) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07560. On Apr 26, 2011 this sequence version replaced NP_010015.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..720 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..720 /product="putative serine/threonine protein kinase KIN82" /EC_number="2.7.11.1" /calculated_mol_wt="81331" Region 322..623 /region_name="STKc_phototropin_like" /note="Catalytic domain of Phototropin-like Serine/Threonine Kinases; cd05574" /db_xref="CDD:270726" Site order(330..334,338,351,353,385,401..402,404,408,410,449, 451,453..454,456,466..467,470,502..507,534,540,543) /site_type="active" /db_xref="CDD:270726" Site order(330..334,338,351,353,385,402..404,408,449,451, 453..454,456,466..467) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270726" Site order(334,408,410,449,451,453,470,502..507,534,540,543) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:270726" Site order(466..475,499..507) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270726" CDS 1..720 /gene="KIN82" /locus_tag="YCR091W" /gene_synonym="FPK2" /coded_by="NM_001178797.2:1..2163" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:genetic interaction:GO:0045332 phospholipid translocation [PMID:18199685]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:11337509]" /note="Putative serine/threonine protein kinase; implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases); involved in the phosphorylation of upstream inhibitory kinase Ypk1p along with Fpk1p; has a redundant role in the cellular response to mating pheromone; KIN82 has a paralog, FPK1, that arose from the whole genome duplication" /db_xref="GeneID:850453" /db_xref="SGD:S000000687" ORIGIN 1 mtqqeyrsps qrlskgrsms lpkifarnlr slqnnappgk ninvnclnvn scslsaspss 61 qinmacngnk qdlpipfplh vecndswsss klnkfksmfn hnrskssgtt dastsekgth 121 kreprstiht ellqssiige pnvhsttsst lipneaicst pneisgsssp daelftfdmp 181 tdpssfhtps spsyiakdsr nlsngslndi neneelqnfh rkisengsas planlslsns 241 pidsprknse trkdqipmni tprlrraase pfntakdglm redyialkqp pslgdivepr 301 rsrrlrtksf gnkfqditve pqsfekirll gqgdvgkvyl vrerdtnqif alkvlnkhem 361 ikrkkikrvl teqeilatsd hpfivtlyhs fqtkdylylc meycmggeff ralqtrkskc 421 iaeedakfya sevvaaleyl hllgfiyrdl kpenillhqs ghvmlsdfdl siqatgskkp 481 tmkdstyldt kicsdgfrtn sfvgteeyla pevirgnght aavdwwtlgi liyemlfgct 541 pfkgdnsnet fsniltkdvk fphdkevskn ckdlikklln kneakrlgsk sgaadikrhp 601 ffkkvqwsfl rnqdpplipa lndngcelpf ilscnkhpkr nsvseqetkm fcekvandde 661 ideadpfhdf nsmsltkkdh niltysenyt ygkilykatc trprhnsshr sffkdiipel // LOCUS NP_010016 1018 aa linear PLN 30-JUN-2025 DEFINITION mismatch repair protein MSH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010016 VERSION NP_010016.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178798.1 REFERENCE 1 (residues 1 to 1018) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1018) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1018) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 1018) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1018) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1018) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1018) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1018) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1018) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07561. On Sep 17, 2007 this sequence version replaced NP_010016.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1018 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..1018 /product="mismatch repair protein MSH3" /calculated_mol_wt="116403" Region 130..1012 /region_name="PRK05399" /note="DNA mismatch repair protein MutS; Provisional" /db_xref="CDD:235444" CDS 1..1018 /gene="MSH3" /locus_tag="YCR092C" /coded_by="NM_001178798.1:1..3057" /experiment="EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:16781730]" /experiment="EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:16781730]" /experiment="EXISTENCE:direct assay:GO:0000406 double-strand/single-strand DNA junction binding [PMID:16781730]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030983 mismatched DNA binding [PMID:17636021]" /experiment="EXISTENCE:direct assay:GO:0032135 DNA insertion or deletion binding [PMID:8805366]" /experiment="EXISTENCE:genetic interaction:GO:0000735 removal of nonhomologous ends [PMID:9256462]" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:16702432]" /experiment="EXISTENCE:mutant phenotype:GO:0000735 removal of nonhomologous ends [PMID:9256462]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:9520271|PMID:8510668]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:15920474]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:8849883]" /experiment="EXISTENCE:mutant phenotype:GO:0043111 replication fork arrest [PMID:27045900]" /experiment="EXISTENCE:physical interaction:GO:0032302 MutSbeta complex [PMID:8805366]" /note="Mismatch repair protein; forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability" /db_xref="GeneID:850454" /db_xref="SGD:S000000688" ORIGIN 1 magqptisrf fkkavkselt hkqeqevavg ngagsesicl dtdeednlss vasttvtnds 61 fplkgsvssk nsknsektsg tsttfndidf akkldrimkr rsdenveaed deeegeedfv 121 kkkarkspta kltpldkqvk dlkmhhrdkv lvirvgykyk cfaedavtvs rilhiklvpg 181 kltidesnpq dcnhrqfayc sfpdvrlnvh lerlvhhnlk vavveqaets aikkhdpgas 241 kssvferkis nvftkatfgv nstfvlrgkr ilgdtnsiwa lsrdvhqgkv akyslisvnl 301 nngevvydef eepnladekl qirikylqpi evlvntddlp lhvakffkdi scplihkqey 361 dledhvvqai kvmnekiqls pslirlvskl yshmveynne qvmlipsiys pfaskihmll 421 dpnslqsldi fthdggkgsl fwlldhtrts fglrmlrewi lkplvdvhqi eerldaieci 481 tseinnsiff eslnqmlnht pdllrtlnri mygttsrkev yfylkqitsf vdhfkmhqsy 541 lsehfkssdg rigkqspllf rlfselnell sttqlphflt minvsavmek nsdkqvmdff 601 nlnnydcseg iikiqreses vrsqlkeela eirkylkrpy lnfrdevdyl ievknsqikd 661 lpddwikvnn tkmvsrfttp rtqkltqkle yykdllires elqykeflnk itaeytelrk 721 itlnlaqydc ilslaatscn vnyvrptfvn gqqaiiakna rnpiiesldv hyvpndimms 781 pengkiniit gpnmggkssy irqvalltim aqigsfvpae eirlsifenv ltrigahddi 841 ingdstfkve mldilhilkn cnkrslllld evgrgtgthd giaisyalik yfselsdcpl 901 ilftthfpml geiksplirn yhmdyveeqk tgedwmsvif lyklkkglty nsygmnvakl 961 arldkdiinr afsiseelrk esinedalkl fsslkrilks dnitatdkla kllsldih // LOCUS NP_010017 2108 aa linear PLN 30-JUN-2025 DEFINITION CCR4-NOT core subunit CDC39 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010017 VERSION NP_010017.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178799.1 REFERENCE 1 (residues 1 to 2108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2108) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 2108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 2108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 2108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07562. On Sep 29, 2000 this sequence version replaced NP_010017.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..2108 /product="CCR4-NOT core subunit CDC39" /calculated_mol_wt="240149" Region 1..2108 /region_name="CDC39" /note="Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]; COG5103" /db_xref="CDD:227434" CDS 1..2108 /gene="CDC39" /locus_tag="YCR093W" /gene_synonym="NOT1; ROS1; SMD6" /coded_by="NM_001178799.1:1..6327" /experiment="EXISTENCE:direct assay:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:27692063]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7926748]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly [PMID:27692063]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:11404327]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11889048]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:2099190]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:11404327]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]" /experiment="EXISTENCE:mutant phenotype:GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly [PMID:27692063]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:2680756]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10490603]" /experiment="EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:10490603]" /note="Subunit of the CCR4-NOT1 core complex; this complex has multiple roles in the regulation of mRNA levels including regulation of transcription and destabilization of mRNA by deadenylation; basal transcription factor that increases initiation and elongation; activates the ATPase activity of Dhh1p, resulting in processing body disassembly" /db_xref="GeneID:850455" /db_xref="SGD:S000000689" ORIGIN 1 mlsatyrdln tasnletske kqaaqiviaq isllfttlnn dnfesverei rhildrssvd 61 iyikvwerll tlssrdilqa gkfllqenll hrlllefakd lpkkstdlie llkertfnnq 121 efqkqtgitl slfidlfdks ankdiiesld rssqindfkt ikmnhtnylr nfflqttpet 181 lesnlrdllh slegeslndl lalllseils pgsqnlqndp trswltppmv ldatnrgnvi 241 arsisslqan qinwnrvfnl mstkyflsap lmpttaslsc lfaalhdgpv ideffscdwk 301 vifkldlaiq lhkwsvqngc fdllnaegtr kvsetipntk qsllyllsia slnlelflqr 361 eelsdgpmla yfqecffedf nyapeylila lvkemkrfvl lienrtvide ilitlliqvh 421 nkspssfkdv istitddski vdaakiiins ddapianflk slldtgrldt vinklpfnea 481 fkilpcarqi gwegfdtflk tkvspsnvdv vleslevqtk mtdtntpfrs lktfdlfafh 541 slievlnkcp ldvlqlqrfe slefslliaf prlinfgfgh deailangdi aginndieke 601 mqnylqkmys gelaikdvie llrrlrdsdl prdqevftci thaviaestf fqdypldala 661 ttsvlfgsmi lfqllrgfvl dvafriimrf akeppeskmf kfavqaiyaf rirlaeypqy 721 ckdllrdvpa lksqaqvyqs iveaatlana pkersrpvqe miplkffavd evscqinqeg 781 apkdvvekvl fvlnnvtlan lnnkvdelkk sltpnyfswf stylvtqrak tepnyhdlys 841 kvivamgsgl lhqfmvnvtl rqlfvllstk deqaidkkhl knlaswlgci tlalnkpikh 901 kniafremli eaykenrlei vvpfvtkilq raseskifkp pnpwtvgilk llielnekan 961 wklsltfeve vllksfnltt kslkpsnfin tpevietlsg algsitleqq qteqqrqiil 1021 mqqhqqqmli yqqrqqqqqq rqqqqqhhis antiadqqaa fggegsishd npfnnllgst 1081 ifvthpdlkr vfqmalaksv reillevvek ssgiavvttt kiilkdfate vdesklktaa 1141 iimvrhlaqs laratsiepl kegirstmqs lapnlmslss spaeeldtai nenigialvl 1201 iekasmdkst qdladqlmqa iairryhker radqpfitqn tnpyslslpe plglkntgvt 1261 pqqfrvyeef gknipnldvi pfaglpahap pmtqnvgltq pqqqqaqmpt qiltseqira 1321 qqqqqqlqks rlnqpsqsaq ppgvnvpnpq ggiaavqsdl eqnqrvlvhl mdilvsqike 1381 natknnlael gdqnqiktii fqiltfiaks aqkdqlalkv sqavvnslfa tsesplcrev 1441 lsllleklcs lslvarkdvv wwlvyaldsr kfnvpvirsl levnlidate ldnvlvtamk 1501 nkmenstefa mkliqntvls ddpilmrmdf iktlehlass edenvkkfik efedtkimpv 1561 rkgtkttrte klylvftewv kllqrvennd vittvfikql vekgvisdtd nlltfvkssl 1621 elsvssfkes dptdevfiai dalgsliikl lilqgfkddt rrdyinaifs vivlvfakdh 1681 sqegttfner pyfrlfsnil yewatirthn fvrisdsstr qeliefdsvf yntfsgylha 1741 lqpfafpgfs fawvtllshr mllpimlrlp nkigweklml liidlfkfld qytskhavsd 1801 avsvvykgtl rvilgisndm psflienhye lmnnlpptyf qlknvilsai pknmtvpnpy 1861 dvdlnmedip ackelpevff dpvidlhslk kpvdnylrip snsllrtils aiykdtydik 1921 kgvgydflsv dskliraivl hvgieagiey krtssnavfn tkssyytllf nliqngsiem 1981 kyqiilsive qlrypnihty wfsfvlmnmf ksdewndqkl evqeiilrnf lkriivnkph 2041 twgvsvfftq linnndinll dlpfvqsvpe iklilqqlvk yskkyttseq ddqsatinrr 2101 qtplqsna // LOCUS NP_010018 391 aa linear PLN 30-JUN-2025 DEFINITION aminophospholipid translocase regulatory protein CDC50 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010018 VERSION NP_010018.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178800.1 REFERENCE 1 (residues 1 to 391) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 391) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 391) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 391) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07563. Method: conceptual translation. FEATURES Location/Qualifiers source 1..391 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..391 /product="aminophospholipid translocase regulatory protein CDC50" /calculated_mol_wt="44852" Region 1..369 /region_name="CDC50" /note="Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal transduction mechanisms]; COG5035" /db_xref="CDD:227368" CDS 1..391 /gene="CDC50" /locus_tag="YCR094W" /coded_by="NM_001178800.1:1..1176" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:15090616]" /experiment="EXISTENCE:direct assay:GO:0031902 late endosome membrane [PMID:12589066]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:16195350]" /experiment="EXISTENCE:genetic interaction:GO:0015247 aminophospholipid flippase activity [PMID:15090616]" /experiment="EXISTENCE:genetic interaction:GO:0045332 phospholipid translocation [PMID:15090616]" /experiment="EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:16195350]" /experiment="EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:16956384]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:28057802]" /experiment="EXISTENCE:physical interaction:GO:1990530 Cdc50p-Drs2p complex [PMID:15090616]" /note="Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication" /db_xref="GeneID:850456" /db_xref="SGD:S000000690" ORIGIN 1 mvslfkrgka ppltkegpts kkppntafrq qrlkawqpil spqsvlplli fvaciftpig 61 iglivsatkv qdltidyshc dtkasttafe dipkkyikyh fkskvenkpq wrltenenge 121 qscelqfeip ndikksifiy ykitnfyqnh rryvqsfdtk qilgepikkd dldtscspir 181 sredkiiypc gliansmfnd tfsqvlsgid dtedynltnk hiswsidrhr fkttkynasd 241 ivpppnwmkk ypdgytdenl pdihtweefq vwmrtaafpk fykltlknes aslpkgkyqm 301 nielnypisl fggtksfvlt tngaiggrnm slgvlyliva glcalfgiif lvklifqpra 361 mgdhtylnfd deenedyedv haenttlrei l // LOCUS NP_010019 362 aa linear PLN 30-JUN-2025 DEFINITION Oca4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010019 VERSION NP_010019.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178801.1 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 362) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07564. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..362 /product="Oca4p" /calculated_mol_wt="41516" Region 2..198 /region_name="PFA-DSP_Oca4" /note="atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 4; cd17662" /db_xref="CDD:350500" CDS 1..362 /gene="OCA4" /locus_tag="YCR095C" /coded_by="NM_001178801.1:1..1089" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts" /db_xref="GeneID:850457" /db_xref="SGD:S000000691" ORIGIN 1 mlvppanfgi aeegiyrcsk vetlnlsfle tlnlktaifi ggqepskffk dfftrssikw 61 ivlrmsdfsa aavpvksssv snanlysnnn stlslqeekk kstangsqns ttgdpviqee 121 layhltdndd lmlikstclk rtfktllnvd nynvllvdkt alvigilrki qkwniasiin 181 eyrlfsgknr nyfaetflei inieieqekd nktivdnkak klplennrth sieykansgk 241 lirvneddlc repevpqrll tlinqietkv knnkvlqvsg vlgddlkkts sdlgifghry 301 rlafnkkeng dygyykargk dnvkiripcd selpdwfrfq rdlwekenvp eehhfyrehi 361 ft // LOCUS NP_001018032 52 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR095W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001018032 VERSION NP_001018032.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184674.1 REFERENCE 1 (residues 1 to 52) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 52) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 52) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 52) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07565. Method: conceptual translation. FEATURES Location/Qualifiers source 1..52 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..52 /product="uncharacterized protein" /calculated_mol_wt="6166" CDS 1..52 /locus_tag="YCR095W-A" /coded_by="NM_001184674.1:1..159" /note="hypothetical protein" /db_xref="GeneID:3077354" /db_xref="SGD:S000029724" ORIGIN 1 mtvliklglr ilhvykgffr kvilkyfffs sehtkvnkks smhaflckiy kr // LOCUS NP_010020 119 aa linear PLN 30-JUN-2025 DEFINITION homeodomain mating type protein a2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010020 VERSION NP_010020.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178802.1 REFERENCE 1 (residues 1 to 119) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 119) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 119) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 119) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07566. Method: conceptual translation. FEATURES Location/Qualifiers source 1..119 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..119 /product="homeodomain mating type protein a2" /calculated_mol_wt="13751" Site order(41..43,45,65,71,84,86..87,90..91,93..95,97) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" Site order(41,44,87,90..91,94) /site_type="other" /note="specific DNA base contacts [nucleotide binding]" /db_xref="CDD:238039" Region 44..97 /region_name="HOX" /note="Homeodomain; smart00389" /db_xref="CDD:197696" CDS 1..119 /gene="HMRA2" /locus_tag="YCR096C" /gene_synonym="A2" /coded_by="NM_001178802.1:1..360" /note="Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system" /db_xref="GeneID:850458" /db_xref="SGD:S000000692" ORIGIN 1 mrsiendrsn yqltqknksa dglvfnvvtq dminkstkpy rghrftkenv rileswfakn 61 ienpyldtkg lenlmkntsl sriqiknwvs nrrrkektit iapeladlls geplakkke // LOCUS NP_010021 126 aa linear PLN 30-JUN-2025 DEFINITION Hmra1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010021 VERSION NP_010021.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178804.1 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 126) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07567. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..126 /product="Hmra1p" /calculated_mol_wt="14672" Region 70..126 /region_name="HOX" /note="Homeodomain; smart00389" /db_xref="CDD:197696" Site order(71..75,77,94,100,113,115..116,119..120,122..124,126) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238039" Site order(73,76,116,119..120,123) /site_type="other" /note="specific DNA base contacts [nucleotide binding]" /db_xref="CDD:238039" CDS 1..126 /gene="HMRA1" /locus_tag="YCR097W" /gene_synonym="YCR097WB" /coded_by="NM_001178804.1:1..381" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:1977088]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8411150]" /experiment="EXISTENCE:direct assay:GO:0007532 regulation of mating-type specific transcription, DNA-templated [PMID:1977088]" /note="Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells" /db_xref="GeneID:850459" /db_xref="SGD:S000000694" ORIGIN 1 mddicsmaen inrtlfnilg teideinlnt nnlynfimes nltkveqhtl hknisnnrle 61 iyhhikkeks pkgkssispq arafleqvfr rkqslnskek eevakkcgit plqvrvwfin 121 krmrsk // LOCUS NP_010022 518 aa linear PLN 30-JUN-2025 DEFINITION Git1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010022 VERSION NP_010022.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178805.1 REFERENCE 1 (residues 1 to 518) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 518) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 518) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 518) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07568. Method: conceptual translation. FEATURES Location/Qualifiers source 1..518 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..518 /product="Git1p" /calculated_mol_wt="57191" Region 48..454 /region_name="MFS_PhT" /note="Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; cd17364" /db_xref="CDD:340922" Site order(161,189,192,276,280,283..284,382,386) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340922" CDS 1..518 /gene="GIT1" /locus_tag="YCR098C" /coded_by="NM_001178805.1:1..1557" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0001406 glycerophosphodiester transmembrane transporter activity [PMID:16924500]" /experiment="EXISTENCE:direct assay:GO:0001407 glycerophosphodiester transmembrane transport [PMID:16924500]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16924500]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015169 glycerol-3-phosphate transmembrane transporter activity [PMID:20133652]" /experiment="EXISTENCE:genetic interaction:GO:0015794 glycerol-3-phosphate transmembrane transport [PMID:20133652]" /experiment="EXISTENCE:mutant phenotype:GO:0001406 glycerophosphodiester transmembrane transporter activity [PMID:9691030]" /experiment="EXISTENCE:mutant phenotype:GO:0001407 glycerophosphodiester transmembrane transport [PMID:9691030]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:9691030]" /experiment="EXISTENCE:mutant phenotype:GO:0015169 glycerol-3-phosphate transmembrane transporter activity [PMID:20133652]" /experiment="EXISTENCE:mutant phenotype:GO:0015794 glycerol-3-phosphate transmembrane transport [PMID:20133652]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:9691030]" /note="Plasma membrane permease; mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability" /db_xref="GeneID:850462" /db_xref="SGD:S000000695" ORIGIN 1 medkditsvn ekevnentnp riikydaerr atrtetskkd kwknivtiia sgfalisdgy 61 vngsmsmlnk vfvmeygkkn ysskvstrvs naalvgiifg qffmgiaady ysrkscilva 121 tailvigsal caashgttvp gmfwmltvmr glvgigvgae yptstlsane saneytttkr 181 ggilvmvtnl plafggpfat iiflivykic sgtkhleaiw rtvfaigcfw plsvfyfrwk 241 tattevyekg rikrnipyfl alkfywkrll gtcgtwfmyd fvtfpngifs stiissvikd 301 qndlvkvaew nlllgvlavl gvpigaylsd rigrkytlmf gfsgyiifgl iigcaydqlk 361 kitplfiify afmnmlgnag pgdmlgviss easatavrgv fyglsavtgk igsvvgvecf 421 qpirdnlgar wtfiiaaicg ligiiityff vphslesdlm kqdvefhnyl vsngwtgkmg 481 fdetdeesmv rtieveengt ncskknaeii svrqvdqs // LOCUS NP_010023 155 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR099C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010023 VERSION NP_010023.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178806.1 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 155) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07569. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..155 /product="uncharacterized protein" /calculated_mol_wt="17828" Region <3..130 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" CDS 1..155 /locus_tag="YCR099C" /coded_by="NM_001178806.1:1..468" /note="hypothetical protein" /db_xref="GeneID:850463" /db_xref="SGD:S000000696" ORIGIN 1 mrsifllhfd yktceeedfe dwnladgkcl ngakymykrr kqdarclvkr tfkdmilhei 61 pcdsctesdy ecssefvrda kgdcipdydq ialsdicdka ngetvslepl qlikgdkckk 121 pmeieamnip cekilressn gkkiatienk fdfei // LOCUS NP_010024 316 aa linear PLN 30-JUN-2025 DEFINITION Ema35p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010024 VERSION NP_010024.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178807.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 316) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07570. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..316 /product="Ema35p" /calculated_mol_wt="35126" Region <1..>316 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" CDS 1..316 /gene="EMA35" /locus_tag="YCR100C" /coded_by="NM_001178807.1:1..951" /note="Protein involved in protein sorting; involved in targeting mitochondrial membrane proteins to mitochondrial translocation system; mutation causes respiration defects" /db_xref="GeneID:850464" /db_xref="SGD:S000000697" ORIGIN 1 msstdiwisn dastfqkaql ptqlrhvkvi kiredsigri illisteitn eenadpdlse 61 ifisdsqglk fspvewtpnh qfgnfrltfp dflkgtifgs fhpsidysnh qvnyteniag 121 getkisvdng ltwsnlkvvd eenadsfgcd itrpercslq gyfynlklsn psagiilmtg 181 svgddnefdr kdrktfisrd ggltwrvahn ssglyatgdl gniivyipsp sykdgdvqsk 241 lyfsldqgrt wnqyelvdal fyihplelin ttpdgsgskf ilsghlitta sqegnntnis 301 yiarsvlyai dfsaaf // LOCUS NP_010025 182 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR101C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010025 VERSION NP_010025.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178808.1 REFERENCE 1 (residues 1 to 182) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 182) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 182) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 182) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07571. Method: conceptual translation. FEATURES Location/Qualifiers source 1..182 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..182 /product="uncharacterized protein" /calculated_mol_wt="20994" Region 36..>166 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" CDS 1..182 /locus_tag="YCR101C" /coded_by="NM_001178808.1:1..549" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11935221]" /note="hypothetical protein; localizes to the membrane fraction; YCR101C is not an essential gene" /db_xref="GeneID:850465" /db_xref="SGD:S000000698" ORIGIN 1 millhaiytl wviillplln aekfvpkvte apietsfnlv sfddsntsir ldgwgvvwis 61 fdagenwetv keieerifrf tvdpfhgqer gfaficespk fyitddrges wraltipsse 121 eyldgdcfit thprnkelli ancysymida dvlydpseiy lsndgnpflk lnlpwkrkkt 181 ti // LOCUS NP_010026 368 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR102C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010026 VERSION NP_010026.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178809.1 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 368) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07572. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..368 /product="uncharacterized protein" /calculated_mol_wt="39990" Region 1..367 /region_name="enoyl_reductase_like" /note="cd08249" /db_xref="CDD:176211" Site order(38..39,144,176..179,200..201,203..204,219,241..242, 266..267,288,290,359..360) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:176211" CDS 1..368 /locus_tag="YCR102C" /coded_by="NM_001178809.1:1..1107" /experiment="EXISTENCE:direct assay:GO:0071468 cellular response to acidic pH [PMID:31374572]" /experiment="EXISTENCE:mutant phenotype:GO:0046688 response to copper ion [PMID:15886332]" /note="Putative quinone oxidoreductase; overexpression improves ethanol production and acid stress resistance; involved in copper metabolism; similar to Cochliobolus carbonum toxD gene" /db_xref="GeneID:850466" /db_xref="SGD:S000000699" ORIGIN 1 mkavviedgk avvkegvpip eleegfvlik tlavagnptd wahidykvgp qgsilgcdaa 61 gqivklgpav dpkdfsigdy iygfihgssv rfpsngafae ysaistvvay kspnelkflg 121 edvlpagpvr slegaatipv slttaglvlt ynlglnlkwe pstpqrngpi llwggatavg 181 qsliqlankl ngftkiivva srkhekllke ygadqlfdyh didvveqikh kynnisylvd 241 cvanqntlqq vykcaadkqd atvveltnlt eenvkkenrr qnvtidrtrl ysigghevpf 301 ggitfpadpe arraatefvk finpkisdgq ihhiparvyk nglydvpril edikigknsg 361 eklvavln // LOCUS NP_010029 124 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010029 VERSION NP_010029.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178811.1 REFERENCE 1 (residues 1 to 124) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 124) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 124) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 124) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07573. Method: conceptual translation. FEATURES Location/Qualifiers source 1..124 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..124 /product="seripauperin PAU3" /calculated_mol_wt="13056" Region 26..118 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..124 /gene="PAU3" /locus_tag="YCR104W" /coded_by="NM_001178811.1:1..375" /note="Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme" /db_xref="GeneID:850468" /db_xref="SGD:S000000701" ORIGIN 1 mvkltsiaag vaaiaagiaa apatttlsps dervnlvelg vyvsdirahl aqyylfqaah 61 ptetypveia eavfnygdft tmltgipaeq vtrvitgvpw ystrlrpais salskdgiyt 121 aipk // LOCUS NP_010030 361 aa linear PLN 30-JUN-2025 DEFINITION NADP-dependent alcohol dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010030 VERSION NP_010030.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178812.1 REFERENCE 1 (residues 1 to 361) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 361) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 361) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 361) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07574. Method: conceptual translation. FEATURES Location/Qualifiers source 1..361 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..361 /product="NADP-dependent alcohol dehydrogenase" /EC_number="1.1.1.2" /calculated_mol_wt="39217" Region 8..353 /region_name="CAD1" /note="Cinnamyl alcohol dehydrogenases (CAD); cd05283" /db_xref="CDD:176186" Site order(46,48,68,95,164,302) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:176186" Site order(46,68,164) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176186" Site order(100,103,106,114) /site_type="other" /note="structural Zn binding site [ion binding]" /db_xref="CDD:176186" Site order(113,171,175,270,275..277,279,288,290..291,294..301) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:176186" CDS 1..361 /gene="ADH7" /locus_tag="YCR105W" /gene_synonym="ADHVII" /coded_by="NM_001178812.1:1..1086" /experiment="EXISTENCE:direct assay:GO:0006066 alcohol metabolic process [PMID:12423374]" /experiment="EXISTENCE:direct assay:GO:0008106 alcohol dehydrogenase (NADP+) activity [PMID:12423374]" /note="NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance" /db_xref="GeneID:850469" /db_xref="SGD:S000000702" ORIGIN 1 mlypekfqgi gisnakdwkh pklvsfdpkp fgdhdvdvei eacgicgsdf hiavgnwgpv 61 penqilghei igrvvkvgsk chtgvkigdr vgvgaqalac fecercksdn eqyctndhvl 121 tmwtpykdgy isqggfashv rlhehfaiqi penipsplaa pllcggitvf spllrngcgp 181 gkrvgivgig gighmgilla kamgaevyaf srghskreds mklgadhyia mledkgwteq 241 ysnaldllvv cssslskvnf dsivkimkig gsivsiaape vneklvlkpl glmgvsisss 301 aigsrkeieq llklvseknv kiwveklpis eegvshaftr mesgdvkyrf tlvdydkkfh 361 k // LOCUS NP_010031 832 aa linear PLN 30-JUN-2025 DEFINITION Rds1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010031 VERSION NP_010031.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178813.1 REFERENCE 1 (residues 1 to 832) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 832) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 832) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 832) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07575. Method: conceptual translation. FEATURES Location/Qualifiers source 1..832 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..832 /product="Rds1p" /calculated_mol_wt="95559" Site order(10,14,19..22,24,27,37) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Region 14..51 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(15,18,25,32,35,42) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 221..>473 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..832 /gene="RDS1" /locus_tag="YCR106W" /coded_by="NM_001178813.1:1..2499" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:11943786]" /note="Putative zinc cluster transcription factor; involved in conferring resistance to cycloheximide" /db_xref="GeneID:850470" /db_xref="SGD:S000000703" ORIGIN 1 mdsitvkkpr lrlvclqckk ikrkcdklrp acsrcqqnsl qceyeertdl sanvaandsd 61 gfnsshklnf eqqpvlertg lryslqvpeg vvnatlsiwn aedmlvivgl vtfldypfaa 121 hslaqhdqyi ralcaslygm alvdfsnyan gipcedtsrs ilgplsfiek aifrriehsk 181 qfrvqsaalg llynafsmee enfstllpsl iaevedvlmq kkdceillrc fyqniypfyp 241 fmdislfesd ltslllqddn nrwkistevk nvrkkietls lltivmamal mhskldanll 301 smvkenases arklsllchk llclldvfry pnentftcll yfyvsehldp espdcvlspt 361 nlltlhhlln lsmtlglqye pskykrfkdp evirqrrilw lgvqsllfqi slaegdagks 421 nseymeaylt dfeeyieass eyekssases nvqmndivwn kykfhvilsk lmsdctsviq 481 hpqlfhilgn ikrsedfmae nfptssiyqp lhekepnaik vgkstvldvm diqkteiflt 541 nivgsmcfln ifdvlslhfe kkcvmhweey eknyhfltlk sfnaylklag lisdylenkf 601 qgnilesrgy iidkqicfml vriwmfqcri llrfsykqes qkklasssis tndnekedem 661 ivilerlikh irnqmahlvd lakgklqdsy fgayqtvpmf ryvvylidvg glvsvtngfw 721 dkissdgeip pkvqqavrlk wgldcnnsrr ikqklissqs lqsfnqvllc qmedavlsss 781 faikantams qntaeeffni seeealnqll ennnfdafwd llgenlsdmp sl // LOCUS NP_010032 363 aa linear PLN 30-JUN-2025 DEFINITION putative aryl-alcohol dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010032 VERSION NP_010032.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178814.1 REFERENCE 1 (residues 1 to 363) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 363) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 363) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 363) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07576. Method: conceptual translation. FEATURES Location/Qualifiers source 1..363 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..363 /product="putative aryl-alcohol dehydrogenase" /calculated_mol_wt="40780" Region 17..335 /region_name="AKR_AKR9A3_9B1-4" /note="Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; cd19147" /db_xref="CDD:381373" Site order(32..34,68,73,100,148..149,178..179,204,232..238,289, 306..311,314,317..318) /site_type="active" /note="putative active site [active]" /db_xref="CDD:381373" Site order(68,73,100,148) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381373" CDS 1..363 /gene="AAD3" /locus_tag="YCR107W" /coded_by="NM_001178814.1:1..1092" /note="Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD3 has a paralog, AAD15, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" /db_xref="GeneID:850471" /db_xref="SGD:S000000704" ORIGIN 1 migsasdsss klgrlrflse taaikvspli lgevsydgar sdflksmnkn rafelldtfy 61 eaggnfidaa nncqneqsee wigewiqsrr lrdqiviatk fiksdkkyka gesntanycg 121 nhkrslhvsv rdslrklqtd widilyvhww dymssieefm dslhilvqqg kvlylgvsdt 181 pawvvsaany yatsygktpf siyqgkwnvl nrdferdiip marhfgmala pwdvmgggrf 241 qskkameerr kngegirsfv gaseqtdaei kisealakia eehgtesvta iaiayvrska 301 knffpsvegg kiedlkenik alsidltpdn ikylesivpf digfpnnfiv lnsltqkygt 361 nnv // LOCUS NP_878059 63 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YCR108C [Saccharomyces cerevisiae S288C]. ACCESSION NP_878059 VERSION NP_878059.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184543.1 REFERENCE 1 (residues 1 to 63) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 63) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 63) AUTHORS Oliver,S.G., van der Aart,Q.J., Agostoni-Carbone,M.L., Aigle,M., Alberghina,L., Alexandraki,D., Antoine,G., Anwar,R., Ballesta,J.P., Benit,P. et al. TITLE The complete DNA sequence of yeast chromosome III JOURNAL Nature 357 (6373), 38-46 (1992) PUBMED 1574125 REFERENCE 4 (residues 1 to 63) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (21-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07577. Method: conceptual translation. FEATURES Location/Qualifiers source 1..63 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="III" Protein 1..63 /product="uncharacterized protein" /calculated_mol_wt="7135" CDS 1..63 /locus_tag="YCR108C" /coded_by="NM_001184543.1:1..192" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466400" /db_xref="SGD:S000028536" ORIGIN 1 mpyspslilm ghthtdatvy ttlklpysht pihgpfslnq yqmhphhyar hlpqrsipca 61 iyp // LOCUS NP_010033 383 aa linear PLN 30-JUN-2025 DEFINITION Cos7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010033 VERSION NP_010033.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180308.1 REFERENCE 1 (residues 1 to 383) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 383) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 383) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 383) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11619. Method: conceptual translation. FEATURES Location/Qualifiers source 1..383 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..383 /product="Cos7p" /calculated_mol_wt="45549" Region 73..167 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 261..353 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..383 /gene="COS7" /locus_tag="YDL248W" /coded_by="NM_001180308.1:1..1152" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0038024 cargo receptor activity [PMID:9560393]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:851348" /db_xref="SGD:S000002407" ORIGIN 1 mkenevkdek svdvlsfkql esqkivlpqd lfrssftwfc yeiykslafr iwmllwlpls 61 vwwklsnnci yplivsllvl flgpifvlvi cglsrkrsls kqliqfckei tentpssdph 121 dwevvvanln sylyenkawn tknfffnatd cekmfrttvl epfslkkdka akvksfkdsv 181 pyieealqvy atgfdkqwkl fitekswspv gledvqlpkd ihrskltwfl kriftiyslp 241 lwlaflncic vsqhfclafr ilcpglfflm mvwlfqnmrt tallvkmehk mqflltiine 301 qesgangwde iarkmnrylf ekkawkneef ffdgidcewf fshffyrlls akksmwllpl 361 nvelwpyike aqlsrneesl mkk // LOCUS NP_010034 609 aa linear PLN 30-JUN-2025 DEFINITION alpha-glucoside permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_010034 VERSION NP_010034.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180307.1 REFERENCE 1 (residues 1 to 609) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 609) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 609) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 609) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11620. Method: conceptual translation. FEATURES Location/Qualifiers source 1..609 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..609 /product="alpha-glucoside permease" /calculated_mol_wt="68058" Region 72..556 /region_name="SP" /note="MFS transporter, sugar porter (SP) family; TIGR00879" /db_xref="CDD:273317" Site order(111..112,115..116,119,163,213..214,216..218,221,241, 244..245,248,368,371..372,375..377,380,408,412,468..469, 473,477,493,496..497,500..501,504) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..609 /gene="MPH2" /locus_tag="YDL247W" /coded_by="NM_001180307.1:1..1830" /experiment="EXISTENCE:direct assay:GO:0005363 maltose transmembrane transporter activity [PMID:12210897]" /experiment="EXISTENCE:direct assay:GO:0008643 carbohydrate transport [PMID:12210897]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:12210897]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; almost identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication" /db_xref="GeneID:851350" /db_xref="SGD:S000002406" ORIGIN 1 mknlsflinr rkentsdsnv ypgkakshep swiemddqtk kdgldivhve fspdtrapsd 61 snkviteifd atedakeade sergmplata lntypkaaaw sllvsttlim egydtailga 121 fyalpifqrk fgsqndktge weisaswqig ltlcymagei vglqltgpsv dlvgnrytli 181 ialfflaaft filyfcnslg miavgqalcg mpwgcfqclt vsyaseicpl alryylttys 241 nlcwlfgqlf aagimknsqk kyadselgyk lpfalqwilp vplalgiffa pespwwlvkk 301 grfdearrsl rrtlsgkgpe keilvtlevd kikvtidkek rltskegsys dcfedkinrr 361 rtritclcwa gqatcgsili gystyfyeka gvstemsftf siiqyclgic atflswwask 421 yfgrydlyaf glafqtivff iigglgcsst hgskmgsgsl lmavaffynl giapvvfclv 481 sempssrlrt ktiilarnty nvvsiicsvl ilyqlnskkw nwgaksgffw gvlcfctliw 541 avvdlpetag ktfveinelf klgvsarkfk stkvdpfvvk tplktslitt preisklplq 601 rnsnvshhl // LOCUS NP_010035 357 aa linear PLN 30-JUN-2025 DEFINITION L-iditol 2-dehydrogenase SOR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010035 VERSION NP_010035.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180306.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11621. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..357 /product="L-iditol 2-dehydrogenase SOR2" /EC_number="1.1.1.9" /calculated_mol_wt="37966" Region 8..353 /region_name="sorbitol_DH" /note="Sorbitol dehydrogenase; cd05285" /db_xref="CDD:176188" Site order(43,45,49,55,58,68,117,120,154,277,300..301) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:176188" Site order(43,45,68..69,154) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176188" Site order(98,101,104,112) /site_type="other" /note="structural Zn binding site [ion binding]" /db_xref="CDD:176188" Site order(158,180..182,201..203,207,222,252..253,255,275..277, 299..301) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:176188" Site order(160,171,173,189,192..194,196,205,221,239,309, 312..313,316) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:176188" CDS 1..357 /gene="SOR2" /locus_tag="YDL246C" /coded_by="NM_001180306.1:1..1074" /experiment="EXISTENCE:mutant phenotype:GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity [PMID:26996892]" /note="Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase" /db_xref="GeneID:851351" /db_xref="SGD:S000002405" ORIGIN 1 msqnsnpavv lekvgdiaie qrpiptikdp hyvklaikat gicgsdihyy rsggigkyil 61 kapmvlghes sgqvvevgda vtrvkvgdrv aiepgvpsry sdetkegsyn lcphmafaat 121 ppidgtlvky ylspedflvk lpegvsyeeg acveplsvgv hsnklagvrf gtkvvvfgag 181 pvglltgava rafgatdvif vdvfdnklqr akdfgatntf nssqfstdka qdladgvqkl 241 lggnhadvvf ecsgadvcid aavkttkvgg tmvqvgmgkn ytnfpiaevs gkemkligcf 301 rysfgdyrda vnlvatgkvn vkplithkfk fedaakaydy niahggevvk tiifgpe // LOCUS NP_010036 567 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010036 VERSION NP_010036.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180305.1 REFERENCE 1 (residues 1 to 567) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 567) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 567) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 567) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11622. Method: conceptual translation. FEATURES Location/Qualifiers source 1..567 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..567 /product="hexose transporter HXT15" /calculated_mol_wt="62801" Region 62..524 /region_name="MFS_HXT" /note="Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; cd17356" /db_xref="CDD:340914" Site order(74,78,205,208..209,212,331..332,336..337,340..341, 366,436..437,440..441,445,468..469,472) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..567 /gene="HXT15" /locus_tag="YDL245C" /gene_synonym="HLT2" /coded_by="NM_001180305.1:1..1704" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015795 sorbitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:genetic interaction:GO:0015797 mannitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:genetic interaction:GO:1902341 xylitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="Putative transmembrane polyol transporter; supports growth on and uptake of mannitol, sorbitol and xylitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" /db_xref="GeneID:851352" /db_xref="SGD:S000002404" ORIGIN 1 maseqsspei nadnlnssaa dvhvqppgek ewsdgfydke vingntpdap krgflgylii 61 yllcypvsfg gflpgwdsgi tagfinmdnf kmnfgsykhs tgeyylsnvr mgllvamfsv 121 gcsiggvafa rladtlgrrl aivivvlvym vgaiiqissn hkwyqyfvgk iiyglgaggc 181 svlcpmllse iaptdlrggl vslyqlnmtf giflgycsvy gtrkysntaq wripvglcfl 241 waliiivgml lvpespryli ecerheeacv siakinkvsp edpwvlkqad einagvlaqr 301 elgeaswkel fsvktkvlqr litgilvqtf lqltgenyff fygttifksv gltdgfetsi 361 vlgtvnffst iiavmvvdki grrkcllfga asmmacmvif asigvkclyp hgqdgpsskg 421 agnamivftc fyifcfattw apvayivvae sfpskvkska msistafnwl wqfligfftp 481 fitgsihfyy gyvfvgclva mflyvffflp etiglsleei qllyeegikp wksaswvpps 541 rrgassrete akkkswkevl kfpksfn // LOCUS NP_010037 340 aa linear PLN 30-JUN-2025 DEFINITION 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010037 VERSION NP_010037.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180304.1 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11623. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..340 /product="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" /calculated_mol_wt="38443" Region 5..255 /region_name="PBP2_THI5" /note="Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily; cd13650" /db_xref="CDD:270368" Site order(12,44,89,114,118,159..160,167,201) /site_type="other" /note="putative chemical substrate binding site [chemical binding]" /db_xref="CDD:270368" CDS 1..340 /gene="THI13" /locus_tag="YDL244W" /coded_by="NM_001180304.1:1..1023" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:12777485]" /note="Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" /db_xref="GeneID:851353" /db_xref="SGD:S000002403" ORIGIN 1 mstdkitfll nwqptpyhip iflaqtkgyf keqgldiail eptnpsdvte ligsgkvdmg 61 lkamihtlaa kargfpvtsv aslldepftg vlylkgsgit edfqslkgkk igyvgefgki 121 qideltkhyg mkpedytavr cgmnvakyii egkidagigi ecmqqvelee ylakqgrpas 181 dakmlridkl aclgcccfct vlyicndefl kknpekvrkf lkaikkatdy vladpvkawk 241 eyidfkpqln ndlsykqyqr cyayfsssly nvhrdwkkvt gygkrlailp pdyvsnytne 301 ylswpepeev sdpleaqrlm aihqekcrqe gtfkrlalpa // LOCUS NP_010038 329 aa linear PLN 30-JUN-2025 DEFINITION putative aryl-alcohol dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010038 VERSION NP_010038.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180303.1 REFERENCE 1 (residues 1 to 329) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 329) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 329) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 329) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11624. Method: conceptual translation. FEATURES Location/Qualifiers source 1..329 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..329 /product="putative aryl-alcohol dehydrogenase" /calculated_mol_wt="36846" Region 1..292 /region_name="AKR_AKR9A3_9B1-4" /note="Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; cd19147" /db_xref="CDD:381373" Site order(25,30,57,105..106,135..136,161,189..195,246,263..268, 271,274..275) /site_type="active" /note="putative active site [active]" /db_xref="CDD:381373" Site order(25,30,57,105) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381373" CDS 1..329 /gene="AAD4" /locus_tag="YDL243C" /coded_by="NM_001180303.1:1..990" /experiment="EXISTENCE:direct assay:GO:0047681 aryl-alcohol dehydrogenase (NADP+) activity [PMID:29079624]" /note="Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" /db_xref="GeneID:851354" /db_xref="SGD:S000002402" ORIGIN 1 mgsmnkeqaf elldafyeag gncidtansy qneeseiwig ewmksrklrd qiviatkftg 61 dykkyevggg ksanycgnhk hslhvsvrds lrklqtdwid ilyvhwwdym ssieevmdsl 121 hilvqqgkvl ylgvsdtpaw vvsaanyyat shgktpfsiy qgkwnvlnrd ferdiipmar 181 hfgmalapwd vmgggrfqsk kameerkkng eglrtvsgts kqtdkevkis ealakvaeeh 241 gtesvtaiai ayvrskaknv fplvggrkie hlkqnieals ikltpeqiey lesiipfdvg 301 fptnfigddp avtkkasllt amsaqisfd // LOCUS NP_001335753 117 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL242W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335753 VERSION NP_001335753.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348898.1 REFERENCE 1 (residues 1 to 117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 117) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80273. Method: conceptual translation. FEATURES Location/Qualifiers source 1..117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..117 /product="uncharacterized protein" /calculated_mol_wt="13124" CDS 1..117 /locus_tag="YDL242W" /coded_by="NM_001348898.1:1..354" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:851355" /db_xref="SGD:S000002401" ORIGIN 1 mnleesqsnr gtlnikkilv ivcmtnkick hliqslllsk rrlvsvlfdn yqgdmklrss 61 psaiplvpst kilqamearn divdsliins hatesdrrtl gdhevrqced tnfgfki // LOCUS NP_010040 123 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL241W [Saccharomyces cerevisiae S288C]. ACCESSION NP_010040 VERSION NP_010040.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180301.1 REFERENCE 1 (residues 1 to 123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 123) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11625. Method: conceptual translation. FEATURES Location/Qualifiers source 1..123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..123 /product="uncharacterized protein" /calculated_mol_wt="13363" CDS 1..123 /locus_tag="YDL241W" /coded_by="NM_001180301.1:1..372" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDL241W is not an essential gene" /db_xref="GeneID:851356" /db_xref="SGD:S000002400" ORIGIN 1 mnvtenallf kcgskgyinq tytpteiync gvaegkktak eknptysify dtfltgqpae 61 spetftcgsh gftnasyvas dfyacgflqg kgtetnagih ntrpshslak ftilfmlvly 121 tiv // LOCUS NP_010041 1017 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein LRG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010041 VERSION NP_010041.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180300.2 REFERENCE 1 (residues 1 to 1017) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1017) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1017) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1017) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11626. On Apr 26, 2011 this sequence version replaced NP_010041.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1017 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1017 /product="GTPase-activating protein LRG1" /calculated_mol_wt="116521" Region 28..90 /region_name="LIM1_Lrg1p_like" /note="The first LIM domain of Lrg1p, a LIM and RhoGap domain containing protein; cd09391" /db_xref="CDD:188777" Site order(28,31,54,57,60,63,86,89) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:188777" Region 98..149 /region_name="LIM" /note="LIM is a small protein-protein interaction domain, containing two zinc fingers; cd08368" /db_xref="CDD:259829" Site order(98,101,118,121,124,127,145,148) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:259829" Region 419..475 /region_name="LIM3_Lrg1p_like" /note="The third LIM domain of Lrg1p, a LIM and RhoGap domain containing protein; cd09393" /db_xref="CDD:188779" Site order(419,422,439,442,445,448,471,474) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:188779" Region 728..959 /region_name="RhoGAP_fLRG1" /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1; cd04397" /db_xref="CDD:239862" Site order(777,815,819,893,896..897,939) /site_type="other" /note="putative GTPase interaction site [polypeptide binding]" /db_xref="CDD:239862" Site 777 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:239862" CDS 1..1017 /gene="LRG1" /locus_tag="YDL240W" /coded_by="NM_001180300.2:1..3054" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11447600]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:15514049]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11447600]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:23613772|PMID:11447600|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:23613772]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:15514049]" /experiment="EXISTENCE:genetic interaction:GO:0000755 cytogamy [PMID:15514049]" /experiment="EXISTENCE:genetic interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:11713681|PMID:11447600]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:11713681|PMID:11447600]" /experiment="EXISTENCE:genetic interaction:GO:0090334 regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [PMID:11447600]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:15514049]" /experiment="EXISTENCE:mutant phenotype:GO:0035024 negative regulation of Rho protein signal transduction [PMID:11713681]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:11713681]" /note="GTPase-activating protein (GAP); contains Rho1p-specific GAP activity, interacting with activated forms of Rho1p; functions along with Sac7p as a negative regulator of the Pkc1p-mediated cell wall integrity signaling pathway; negative regulator of cell wall 1,3-beta-glucan biosynthesis; required for efficient cell fusion; contains a RhoGAP domain and three Lin-11-Isl1-Mec-3 (LIM) domains" /db_xref="GeneID:851358" /db_xref="SGD:S000002399" ORIGIN 1 miqnsagyrs lntaspmtvq vknqkkicar cnklvipdsq rtkttlkalg kyyhescftc 61 qdcqkplkpk yfpyqvdkts esillcqydy frrhnllchv cdtplrglyy tafgyrydee 121 hfscticatp cgvkkcfmyg nqlyckyhfl kyfskrckgc efpisdqyie fpkgeeihcw 181 hpecygihky whvnlaaetv glqylpkley npnsgdkdin ptayeldkqm qafnfilskt 241 wsvlyrfeee aascisdmfq yltsndqlkg iestgllvlk idclfrgldt lnlstnksmp 301 vnsdqecien namaaskysk fpknlstkim iylqllrklg tenknetiti ssfmsvitgl 361 ahflklltrf glytalennk lthsvnpllr flreveknel fennpfqyik tpvnatdsca 421 gcnkyiqeec iqfyehrwhi acftcsschk ninprsltdp tfnkekkkil cshcsiddpa 481 svpgfkfvtk laqlifllki alvksrtvml kskasnkvgr nslqstmlke qtyirtlndi 541 krlrsrresv rvthnkqqar ksviletaet dlndptkqgd sknlviqtdd psssqqvstr 601 envfsntktl tlddisriva aeqarelrpn afahfkklke tddetsnvvp kksgvyysel 661 stmelsmira islsllagkq lisktdpnyt slvsmvfsne kqvtgsfwnr mkimmsmepk 721 kpitktvfga pldvlcekwg vdsdlgvgpv kiripiiide lisslrqmdm svegifrkng 781 nirrlrelta nidsnpteap dfskenaiql sallkkfire lpqpilstdl yelwikaaki 841 dledekqrvi lliysllpty nrnllealls flhwtssfsy ienemgskmd ihnlstvitp 901 nilylrhkei sndnvpdepe sglvdsfaqn kgenyflaie ivdylithne emamvpkflm 961 nllkdvqlqk ldnyesinhf istvmqskti dysecdiktp vtvkdstttv iqgeink // LOCUS NP_010042 790 aa linear PLN 30-JUN-2025 DEFINITION Ady3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010042 VERSION NP_010042.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180299.2 REFERENCE 1 (residues 1 to 790) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 790) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 790) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 790) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11627. On Apr 26, 2011 this sequence version replaced NP_010042.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..790 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..790 /product="Ady3p" /calculated_mol_wt="91681" Region <196..>658 /region_name="PRK03918" /note="DNA double-strand break repair ATPase Rad50" /db_xref="CDD:235175" Region 655..789 /region_name="SID" /note="Septation initiation; pfam11778" /db_xref="CDD:403090" CDS 1..790 /gene="ADY3" /locus_tag="YDL239C" /coded_by="NM_001180299.2:1..2373" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:11742972|PMID:11973299]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:11742972|PMID:11973299]" /experiment="EXISTENCE:direct assay:GO:0070056 prospore membrane leading edge [PMID:11742972|PMID:24390141|PMID:11973299]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:17905927]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:17905927]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:11973299]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:11742972]" /experiment="EXISTENCE:physical interaction:GO:0005816 spindle pole body [PMID:11973299]" /note="Protein required for spore wall formation; subunit of leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms ring-like structure at leading edge of prospore membrane during meiosis II; mediates assembly of LEP complex, formation of ring-like structure via interaction with spindle pole body components, and prospore membrane maturation; also detected in peroxisomes; potentially phosphorylated by Cdc28p; ADY3 has a paralog, CNM67, that arose from the whole genome duplication" /db_xref="GeneID:851359" /db_xref="SGD:S000002398" ORIGIN 1 mnhwlaflnk peslkeqnsd cdqqgemrhv tdgtltkspe skpfrerrsq twidsevpts 61 teksnvqesi ssdiisklsn rrsrrnrses wagseassps gnistlenat ekntlkspnk 121 flqrgglptv gigsqalspa gkpstlgnvs pgkfttykvh nsievnrfss tptklltnph 181 kvaaisndeh yvvsneslee nievahlenv frssktpdee qseymklgei rlssssyggs 241 iskenslpkv ldelqsqnee ikalrqklee kddriqelee lnsmndaklq riedlqkefh 301 nerkaaskrl nivqdrfrke ikkireekit dfqnknaskk eknevtsakt kckafsqrni 361 lvselyrkqk qilnlqqend kflkdinesn nsivklrsev eilksnlqls qdenkklhdn 421 gsfyekrlnd vysymqnlsl fekdlgkfil eemkcghsps mfqngfakly pdfqdiknle 481 nmeqykqlkg kiellekndr irlekiisvf klinerlhfm qqqhshkiky lqkealtkeq 541 qfrlekrrwh dilnlkeenf qklkselkek lilsekiqkn aedklndymn ehqeiveklq 601 nqaliasrws tqiqesenth kkitdelagk qseilkleet ilslkedvfq eklnlkklyg 661 dpstelnfet vgksfphitk ekydslgldi ltdltyvqsq nliknllivl diplktflki 721 vptiviqlrc eltlltkfan dlnlkvfgkq ldfksrrkva mneflnnhdi aevkhpleyd 781 lqalfkyffs // LOCUS NP_010043 489 aa linear PLN 30-JUN-2025 DEFINITION guanine deaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010043 VERSION NP_010043.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180298.1 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11628. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..489 /product="guanine deaminase" /EC_number="3.5.4.3" /calculated_mol_wt="55073" Region 21..483 /region_name="GDEase" /note="Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; cd01303" /db_xref="CDD:238628" Site order(100,102,258,261,297,348) /site_type="active" /db_xref="CDD:238628" CDS 1..489 /gene="GUD1" /locus_tag="YDL238C" /coded_by="NM_001180298.1:1..1470" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006147 guanine catabolic process [PMID:10542258]" /experiment="EXISTENCE:direct assay:GO:0008892 guanine deaminase activity [PMID:15565584]" /note="Guanine deaminase; a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures" /db_xref="GeneID:851360" /db_xref="SGD:S000002397" ORIGIN 1 mtksdllfdk fndkhgkflv ffgtfvdtpk lgelrirekt svgvlngiir fvnrnsldpv 61 kdcldhdssl spedvtvvdi igkdktrnns fyfpgfvdth nhvsqypnvg vfgnstlldw 121 lekytfpiea alaneniare vynkvisktl shgtttvayy ntidlkstkl laqlssllgq 181 rvlvgkvcmd tngpeyyied tktsfestvk vvkyiretic dplvnpivtp rfapscsrel 241 mqqlsklvkd enihvqthls enkeeiqwvq dlfpecesyt dvydkygllt ektvlahcih 301 ltdaearvik qrrcgishcp isnssltsge crvrwlldqg ikvglgtdvs aghscsiltt 361 grqafavsrh lamretdhak lsvseclfla tmggaqvlrm detlgtfdvg kqfdaqmidt 421 napgsnvdmf hwqlkekdqm qeqeqeqgqd pyknpplltn ediiakwffn gddrnttkvw 481 vagqqvyqi // LOCUS NP_010044 390 aa linear PLN 30-JUN-2025 DEFINITION Aim6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010044 VERSION NP_010044.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180297.2 REFERENCE 1 (residues 1 to 390) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 390) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 390) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 390) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 390) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 390) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 390) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 390) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 390) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11629. On Apr 26, 2011 this sequence version replaced NP_010044.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..390 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..390 /product="Aim6p" /calculated_mol_wt="44252" Region 115..382 /region_name="PI-PLCc_GDPD_SF_unchar3" /note="Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; cd08577" /db_xref="CDD:176519" Site order(120,141,143,210,259,352) /site_type="active" /note="putative active site [active]" /db_xref="CDD:176519" Site order(120,156) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:176519" CDS 1..390 /gene="AIM6" /locus_tag="YDL237W" /coded_by="NM_001180297.2:1..1173" /note="hypothetical protein; required for respiratory growth; YDL237W is not an essential gene" /db_xref="GeneID:851361" /db_xref="SGD:S000002396" ORIGIN 1 mlglkgclti ligyviavca lfssrgrnps ltdweklkdq kisnidnfgl tgqhlleffq 61 enlpflsfse ekyrhkhvsl yydvfkeyil rrasskkclp vdsaiaklnk dvnpmpvhsh 121 ndywrklplf eglaygasst eadvwnidek ilavghneay ldpveltldk lytgplleil 181 devncqdsda drkngvffns petslffyid fksddnelty kllmeqyfks lidsgyltyy 241 dmkkdeiiwr pvtviltgny ptsldildng ndngyfessq rfafldapll slepkyskls 301 vaatvsfsql mkhcgsdhwk vslrgrmdsn eiscaksiid gahalklktr iwgaptwpan 361 lvetisrqii hdlgsdllnl dnlfmassli // LOCUS NP_010045 312 aa linear PLN 30-JUN-2025 DEFINITION 4-nitrophenylphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010045 VERSION NP_010045.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180296.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11630. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..312 /product="4-nitrophenylphosphatase" /EC_number="3.1.3.41" /calculated_mol_wt="34494" Region 24..308 /region_name="HAD_Pase_UmpH-like" /note="UmpH/NagD family phosphatase, similar to human PGP phosphoglycolate phosphatase and Schizosaccharomyces pombe PHO2 p-nitrophenylphosphatase; cd07510" /db_xref="CDD:319813" Site order(30..34,62..65,167,196,199,229,253..255,258..259) /site_type="active" /db_xref="CDD:319813" CDS 1..312 /gene="PHO13" /locus_tag="YDL236W" /coded_by="NM_001180296.1:1..939" /experiment="EXISTENCE:direct assay:GO:0004035 alkaline phosphatase activity [PMID:9561742]" /experiment="EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:9561742]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005975 carbohydrate metabolic process [PMID:27294321]" /experiment="EXISTENCE:direct assay:GO:0008967 phosphoglycolate phosphatase activity [PMID:27294321]" /experiment="EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:27294321]" /note="Conserved phosphatase acting as a metabolite repair enzyme; shows specific dephosphorylating activity on two side-products of central carbohydrate metabolism, 2-phosphoglycolate and 4-phosphoerythronate; alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity; human ortholog PGP shows similar substrate specificity, deletion causes similar metabolite accumulation phenotypes, suggesting conserved role in eliminating glycolytic byproducts" /db_xref="GeneID:851362" /db_xref="SGD:S000002395" ORIGIN 1 mtaqqgvpik itnkeiaqef ldkydtflfd cdgvlwlgsq alpytleiln llkqlgkqli 61 fvtnnstksr laytkkfasf gidvkeeqif tsgyasavyi rdflklqpgk dkvwvfgesg 121 igeelklmgy eslggadsrl dtpfdaaksp flvngldkdv scviagldtk vnyhrlavtl 181 qylqkdsvhf vgtnvdstfp qkgytfpgag smieslafss nrrpsycgkp nqnmlnsiis 241 afnldrskcc mvgdrlntdm kfgvegglgg tllvlsgiet eeralkishd yprpkfyidk 301 lgdiytltnn el // LOCUS NP_010046 167 aa linear PLN 30-JUN-2025 DEFINITION Ypd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010046 VERSION NP_010046.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180295.1 REFERENCE 1 (residues 1 to 167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 167) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11631. Method: conceptual translation. FEATURES Location/Qualifiers source 1..167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..167 /product="Ypd1p" /calculated_mol_wt="19038" Region 31..118 /region_name="HPT" /note="Histidine Phosphotransfer domain; smart00073" /db_xref="CDD:197502" Site order(64,67..68,83,86) /site_type="active" /note="putative binding surface [active]" /db_xref="CDD:238041" Site 64 /site_type="active" /db_xref="CDD:238041" CDS 1..167 /gene="YPD1" /locus_tag="YDL235C" /coded_by="NM_001180295.1:1..504" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14665464]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14665464]" /experiment="EXISTENCE:direct assay:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:8808622]" /experiment="EXISTENCE:direct assay:GO:0016772 transferase activity, transferring phosphorus-containing groups [PMID:8808622]" /experiment="EXISTENCE:mutant phenotype:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:8808622]" /experiment="EXISTENCE:physical interaction:GO:0043424 protein histidine kinase binding [PMID:8808622]" /note="Osmotic stress-responsive phosphorelay intermediate sensor protein; phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus" /db_xref="GeneID:851363" /db_xref="SGD:S000002394" ORIGIN 1 mstipseiin wtilneiism ddddsdfskg liiqfidqaq ttfaqmqrql dgeknlteld 61 nlghflkgss aalglqriaw vceriqnlgr kmehffpnkt elvntlsdks iinginided 121 deeikiqvdd kdensiylil iakalnqsrl efklariels kyyntnl // LOCUS NP_010047 746 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein GYP7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010047 VERSION NP_010047.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180294.1 REFERENCE 1 (residues 1 to 746) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 746) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 746) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 746) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11632. Method: conceptual translation. FEATURES Location/Qualifiers source 1..746 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..746 /product="GTPase-activating protein GYP7" /calculated_mol_wt="87175" Region 134..738 /region_name="COG5210" /note="GTPase-activating protein [General function prediction only]" /db_xref="CDD:227535" CDS 1..746 /gene="GYP7" /locus_tag="YDL234C" /coded_by="NM_001180294.1:1..2241" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:38536036]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:35134079|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:38536036]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016192 vesicle-mediated transport [PMID:11118206]" /experiment="EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:18809726]" /note="GTPase-activating protein for yeast Rab family members; members include Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking; regulates Ypt7p activity on late endosomes; contains a PH-like domain" /db_xref="GeneID:851364" /db_xref="SGD:S000002393" ORIGIN 1 mskilfcksk vflhptsdar dniagflllt leanklshqa ilqyipesgl stleiskllk 61 heakvgtcpt stpfviensi nfsnlvntsl gqafeislsq iyciqfrpps pngwyvgslv 121 iyplteqftg fqppvlffhd qlcpsttdkl krlrksmnpf ddsdelywgg vdlrnkinel 181 melkksnlep efwlvnpsln dlrnfvskdl lesynnskkd ttelatagvk lnekfqewkw 241 nvmskiadvt tkstnfidsw ltnnspiqks qidneylqkl lnnekvkqie qdydsarvyl 301 anwslgvkqe aeryqkqnkl fdsyrnnifn dlnltdelsd teinnalqrq fplteakwns 361 lwdendgrlr vtvnevkdfi fhgglendsl rgkvwgflle iypwdssqde rvqidqtlaa 421 eydqlkltws kdflqfdded eeeywndqlf riskdvrrcd rnleifqynt idglppppqq 481 lpanennsts pesandesdd addgvrnphl ihlqnility nvyntnlgyv qgmtdllspi 541 yvimkeewkt fwcfthfmdi mernflrdqs giheqmltlv elvqlmlpel sehlnkcdsg 601 nlffcfrmll vwfkrefeme dimhiwenfw tfyyssqfql ffmlailqkn sqailqhlnq 661 fdqilkffne lngkldwndl mvraellfkk fekmmhvmer dlqnvsssss ssstgvlpcq 721 serltlllsk kpiirhegqr sknsvk // LOCUS NP_010048 458 aa linear PLN 30-JUN-2025 DEFINITION Mfg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010048 VERSION NP_010048.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180293.1 REFERENCE 1 (residues 1 to 458) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 458) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 458) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 458) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11633. Method: conceptual translation. FEATURES Location/Qualifiers source 1..458 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..458 /product="Mfg1p" /calculated_mol_wt="51190" Region <34..>141 /region_name="PAT1" /note="Topoisomerase II-associated protein PAT1; pfam09770" /db_xref="CDD:401645" Region 151..393 /region_name="LIM_bind" /note="LIM-domain binding protein; pfam01803" /db_xref="CDD:426444" CDS 1..458 /gene="MFG1" /locus_tag="YDL233W" /coded_by="NM_001180293.1:1..1377" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Regulator of filamentous growth; interacts with FLO11 promoter and regulates FLO11 expression; binds to transcription factors Flo8p and Mss11p; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YDL233W is not an essential gene" /db_xref="GeneID:851365" /db_xref="SGD:S000002392" ORIGIN 1 myqgppqppp qavpmpyivn nntppypngn infpptaqqn ipptvypqqv pfpgqpqggq 61 fpqpsseqqv fnqlpqvtqt fhnsaqntna tggpgsgsmp mftpvasfph pmataataaa 121 plprsasqas lsmlrvpyhv rkylsnlaml klyeiinevn tamgkiglls fwtelisdif 181 tpdavirysk ksmtdyrefe fiipvfpvic stlgrfgivr mevkvlqlkt qvlsnstiff 241 ncprvtfvyy ypdgsyithf sqmkgafdld lkinwldvsm hsfvpdiewn averllsddt 301 ksteieqifr klkqedvkeq gnsfaennat nvppnfeait qlrsyfdvfr nvsvfgtqeg 361 lmrvmqistv mstlknlrkf qieknidspv talsayidad kkdsgseplh akrrrnsgis 421 prtttlgpng nsntsneelp tsdvndinkd mtkkkmkf // LOCUS NP_010049 36 aa linear PLN 30-JUN-2025 DEFINITION olichyl-diphosphooligosaccharide--protein glycotransferase OST4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010049 VERSION NP_010049.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180292.1 REFERENCE 1 (residues 1 to 36) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 36) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 36) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 36) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11634. Method: conceptual translation. FEATURES Location/Qualifiers source 1..36 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..36 /product="olichyl-diphosphooligosaccharide--protein glycotransferase OST4" /calculated_mol_wt="3854" Region 1..33 /region_name="Ost4" /note="Oligosaccaryltransferase; pfam10215" /db_xref="CDD:431142" CDS 1..36 /gene="OST4" /locus_tag="YDL232W" /coded_by="NM_001180292.1:1..111" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:12810948]" /experiment="EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:10677492]" /experiment="EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]" /experiment="EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]" /note="Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex" /db_xref="GeneID:851366" /db_xref="SGD:S000002391" ORIGIN 1 misdeqlnsl aitfgivmmt liviyhavds tmspkn // LOCUS NP_010050 1125 aa linear PLN 30-JUN-2025 DEFINITION Bre4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010050 VERSION NP_010050.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180291.1 REFERENCE 1 (residues 1 to 1125) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1125) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1125) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1125) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11635. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1125 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1125 /product="Bre4p" /calculated_mol_wt="129595" Region 148..>279 /region_name="ArAE_2_N" /note="Putative ER transporter, 6TM, N-terminal; pfam10337" /db_xref="CDD:370988" Region <734..934 /region_name="YccC" /note="Uncharacterized membrane protein YccC [Function unknown]; COG1289" /db_xref="CDD:440900" CDS 1..1125 /gene="BRE4" /locus_tag="YDL231C" /coded_by="NM_001180291.1:1..3378" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903]" /note="Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport" /db_xref="GeneID:851367" /db_xref="SGD:S000002390" ORIGIN 1 mkryerdrsp tpdpdivkgs ysqtslrslh elnyknpagi sglsfagspq qsvaslsqmr 61 lenlvkdkhw eevedfglee lrdgffdaaf tkpdskarsp nsdidddnga arkklqsgft 121 klseyvwtai yrpiihfprd irkngvsifk ffiayfiaiv icvirpsgrw ighefryflp 181 iavlihhpvr nigvqlemti ssiigasfgl gwsalawyis tatkptanyq ggilfqsltm 241 allfaiwlrs vyrrffyftt sfsisiifth tvrlasskfd lkwqifwdfg isylfgllls 301 llvcvcvsph sgnaelmehy nkclqttktf lmalvdteli kskeqiylaq vkmvktlnid 361 lsqgfrdfvn qltisrfdlq slkslrnslt ametslrvlp iapkifndde lkkmyeelek 421 yrsdsatlsk easaspqssg iptrentpsa fkpigpgllk neiyinalka sfsksifnli 481 lemifvlenl srvlkkyesp nqknnldecv kilshshskl krkiykldvc yrdfvnssff 541 sqellndees vdiflflryl rnsarqlvtv ihdcqvlgen ihwrialpsy plsraltrlp 601 kqcvldegag nvlhyfeakr dvdeifervy ntytsrhkyn kgeeealrld sqggdeksqn 661 rknhtisira idhndfnfht tqnpwrfklw klsrilsgde ckwtlkitfc miflclptwl 721 pesyhwyqef hcwwapltfy llahrrysgn walvmrrlic givgifwgwa anqsrhfgsp 781 yvvctfagli vvpfsinflv yrntkssfta lmcftiiale pyskpnrhyn lttagiwkst 841 wvtglaliig ilvsipinwi vwpfrartel rdsmssllah lgqsyqtvad rylyrdadda 901 ptdltfafsh irevrltqsl eairellkka rhepiiisnf npekyaslin scqfllskii 961 earisgaffe iwdqdfdiet trallslrrd svssvifvfy ilsncfrskn kiprylpnpi 1021 msrkklyhfi kkfsemkdqs hsnlnsggns meknlfkkiy qqkasssgqq qlplpsvans 1081 seidsekmhw tevhgiafar aftdisealf qvescakdil geenf // LOCUS NP_010051 335 aa linear PLN 30-JUN-2025 DEFINITION tyrosine protein phosphatase PTP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010051 VERSION NP_010051.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180290.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11636. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..335 /product="tyrosine protein phosphatase PTP1" /EC_number="3.1.3.48" /calculated_mol_wt="38737" Region 79..323 /region_name="PTP_fungal" /note="fungal protein tyrosine phosphatases; cd18533" /db_xref="CDD:350509" CDS 1..335 /gene="PTP1" /locus_tag="YDL230W" /coded_by="NM_001180290.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:1649172]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:21460040]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:21460040]" /note="Phosphotyrosine-specific protein phosphatase; dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation" /db_xref="GeneID:851368" /db_xref="SGD:S000002389" ORIGIN 1 maaapwyirq rdtdllgkfk fiqnqedgrl reatngtvns rwslgvsiep rndarnryvn 61 impyernrvh lktlsgndyi nasyvkvnvp gqsiepgyyi atqgptrktw dqfwqmcyhn 121 cpldnivivm vtplveynre kcyqywprgg vddtvriask wespggandm tqfpsdlkie 181 fvnvhkvkdy ytvtdikltp tdplvgpvkt vhhfyfdlwk dmnkpeevvp imelcahshs 241 lnsrgnpiiv hcsagvgrtg tfialdhlmh dtldfknite rsrhsdrate eytrdlieqi 301 vlqlrsqrmk mvqtkdqflf iyhaakylns lsvnq // LOCUS NP_010052 613 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family ATPase SSB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010052 VERSION NP_010052.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180289.1 REFERENCE 1 (residues 1 to 613) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 613) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 613) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 613) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11637. Method: conceptual translation. FEATURES Location/Qualifiers source 1..613 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..613 /product="Hsp70 family ATPase SSB1" /EC_number="3.6.4.10" /calculated_mol_wt="66471" Region 6..575 /region_name="PTZ00009" /note="heat shock 70 kDa protein; Provisional" /db_xref="CDD:240227" CDS 1..613 /gene="SSB1" /locus_tag="YDL229W" /gene_synonym="YG101" /coded_by="NM_001180289.1:1..1842" /experiment="EXISTENCE:direct assay:GO:0005516 calmodulin binding [PMID:17146552]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19502427]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9860955]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9670014]" /experiment="EXISTENCE:direct assay:GO:0051083 'de novo' cotranslational protein folding [PMID:9670014]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:20368619]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:1394434]" /experiment="EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:17483428]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:15456889]" /experiment="EXISTENCE:mutant phenotype:GO:0006452 translational frameshifting [PMID:16607023]" /experiment="EXISTENCE:physical interaction:GO:0002181 cytoplasmic translation [PMID:1394434]" /note="Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p; SSB1 has a paralog, SSB2, that arose from the whole genome duplication" /db_xref="GeneID:851369" /db_xref="SGD:S000002388" ORIGIN 1 maegvfqgai gidlgttysc vatyessvei ianeqgnrvt psfvaftpee rligdaaknq 61 aalnprntvf dakrligrrf ddesvqkdmk twpfkvidvd gnpvievqyl eetktfspqe 121 isamvltkmk eiaeakigkk vekavitvpa yfndaqrqat kdagaisgln vlriinepta 181 aaiayglgag ksekerhvli fdlgggtfdv sllhiaggvy tvkstsgnth lggqdfdtnl 241 lehfkaefkk ktgldisdda ralrrlrtaa erakrtlssv tqttvevdsl fdgedfessl 301 trarfedlna alfkstlepv eqvlkdakis ksqidevvlv ggstripkvq kllsdffdgk 361 qleksinpde avaygaavqg ailtgqstsd etkdlllldv aplslgvgmq gdmfgivvpr 421 nttvptikrr tfttcadnqt tvqfpvyqge rvnckentll gefdlknipm mpagepvlea 481 ifevdangil kvtavekstg kssnitisna vgrlsseeie kmvnqaeefk aadeafakkh 541 earqrlesyv asieqtvtdp vlssklkrgs kskieaalsd alaalqiedp sadelrkaev 601 glkrvvtkam ssr // LOCUS NP_010054 586 aa linear PLN 30-JUN-2025 DEFINITION Hop [Saccharomyces cerevisiae S288C]. ACCESSION NP_010054 VERSION NP_010054.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180287.1 REFERENCE 1 (residues 1 to 586) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 586) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 586) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 586) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11638. Method: conceptual translation. FEATURES Location/Qualifiers source 1..586 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..586 /product="Hop" /calculated_mol_wt="65958" Region 1..463 /region_name="Hom_end_hint" /note="Hom_end-associated Hint; pfam05203" /db_xref="CDD:368334" CDS 1..586 /gene="HO" /locus_tag="YDL227C" /coded_by="NM_001180287.1:1..1761" /experiment="EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:6099261|PMID:6313222]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0007534 gene conversion at mating-type locus [PMID:6313222]" /experiment="EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:6297747]" /note="Site-specific endonuclease; required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p, and Ash1p" /db_xref="GeneID:851371" /db_xref="SGD:S000002386" ORIGIN 1 mlsenttilm angeikdian vtansyvmca dgsaarvinv tqgyqkiyni qqktkhrafe 61 gepgrldprr rtvyqrlalq ctaghklsvr vptkplleks grnatkykvr wrnlqqcqtl 121 dgriiiipkn hhktfpmtve gefaakrfie emerskgeyf nfdievrdld yldaqlriss 181 cirfgpvlag ngvlskfltg rsdlvtpavk smawmlglwl gdsttkepei svdsldpklm 241 eslrenakiw glyltvcddh vplrakhvrl hygdgpdenr ktrnlrknnp fwkavtilkf 301 krdldgekqi pefmygehie vreaflagli dsdgyvvkkg egpesykiai qtvyssimdg 361 ivhisrslgm satvttrsar eeiiegrkvq cqftydcnva ggttsqnvls ycrsghktre 421 vppiikrepv yfsftddfqg estvygltie ghknfllgnk ievkscrgcc vgeqlkisqk 481 knlkhcvacp rkgikyfykd wsgknrvcar cygrykfsgh hcinckyvpe arevkkakdk 541 geklgitpeg lpvkgpecik cggilqfdav rgphkscgnn agaric // LOCUS NP_010055 352 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein GCS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010055 VERSION NP_010055.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180286.1 REFERENCE 1 (residues 1 to 352) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 352) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 352) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 352) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11639. Method: conceptual translation. FEATURES Location/Qualifiers source 1..352 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..352 /product="GTPase-activating protein GCS1" /calculated_mol_wt="39165" Region 4..350 /region_name="COG5347" /note="GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]" /db_xref="CDD:227651" CDS 1..352 /gene="GCS1" /locus_tag="YDL226C" /coded_by="NM_001180286.1:1..1059" /experiment="EXISTENCE:direct assay:GO:0003779 actin binding [PMID:10069805]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:15975906|PMID:8816753]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:16452633]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16452633]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9927415]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:10069805]" /experiment="EXISTENCE:mutant phenotype:GO:0005856 cytoskeleton [PMID:10069805]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9927415]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9927415]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10069805]" /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:16926193]" /experiment="EXISTENCE:mutant phenotype:GO:1903047 mitotic cell cycle process [PMID:10069805]" /note="ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; required for prospore membrane formation; regulates phospholipase Spo14p; shares functional similarity with Glo3p; GCS1 has a paralog, SPS18, that arose from the whole genome duplication" /db_xref="GeneID:851372" /db_xref="SGD:S000002385" ORIGIN 1 msdwkvdpdt rrrllqlqki gankkcmdcg apnpqwatpk fgaficleca gihrglgvhi 61 sfvrsitmdq fkpeellrme kggnepltew fkshnidlsl pqkvkydnpv aedykekltc 121 lcedrvfeer ehldfdaskl satsqtaasa tpgvaqsreg tplenrrsat panssnganf 181 qkekneayfa elgkknqsrp dhlppsqggk yqgfgstpak ppqersagss ntlslenfqa 241 dplgtlsrgw glfssavtks fedvnetvik phvqqwqsge lseetkraaa qfgqkfqets 301 sygfqafsnf tknfngnaed sstagnttht eyqkidnndk kneqdedkwd df // LOCUS NP_010056 551 aa linear PLN 30-JUN-2025 DEFINITION septin SHS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010056 VERSION NP_010056.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180285.1 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11640. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..551 /product="septin SHS1" /calculated_mol_wt="62499" Region 1..519 /region_name="CDC3" /note="Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5019" /db_xref="CDD:227352" CDS 1..551 /gene="SHS1" /locus_tag="YDL225W" /gene_synonym="SEP7" /coded_by="NM_001180285.1:1..1656" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:17603111]" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:29321251|PMID:22144691]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:14597621]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0061163 endoplasmic reticulum polarization [PMID:25083872]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:18431499]" /experiment="EXISTENCE:genetic interaction:GO:0000921 septin ring assembly [PMID:17603111]" /experiment="EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:25971666]" /experiment="EXISTENCE:mutant phenotype:GO:0000917 division septum assembly [PMID:17603111]" /experiment="EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:22144691]" /experiment="EXISTENCE:mutant phenotype:GO:0010458 exit from mitosis [PMID:12699621]" /experiment="EXISTENCE:mutant phenotype:GO:0032186 cellular bud neck septin ring organization [PMID:12636916]" /experiment="EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:17603111]" /experiment="EXISTENCE:physical interaction:GO:0005935 cellular bud neck [PMID:25083872]" /note="Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851373" /db_xref="SGD:S000002384" ORIGIN 1 mstastppin lfrrkkehkr gitytmllcg pagtgktafa nnlletkifp hkyqygksna 61 sissnpevkv iaptkvvsfn skngipsyvs efdpmranle pgititstsl elggnkdqgk 121 pemneddtvf fnlimthgig enlddslcse evmsyleqqf divlaeetri krnprfedtr 181 vhvalyfiep tghglrevdv elmksiskyt nvlpiitrad sftkeeltqf rknimfdver 241 ynvpiykfev dpedddlesm eenqalaslq pfaiitsdtr dsegryvrey pwgiisiddd 301 kisdlkvlkn vlfgshlqef kdttqnllye nyrseklssv anaeeigpns tkrqsnapsl 361 snfaslistg qfnssqtlan nlradtprnq vsgnfkeney edngehdsae neqemspvrq 421 lgreikqene nlirsiktes spkflnspdl pertklrnis etvpyvlrhe rilarqqkle 481 eleaqsakel qkriqelerk ahelklrekl inqnklngss ssinslqqst rsqikkndty 541 tdlasiasgr d // LOCUS NP_010057 649 aa linear PLN 30-JUN-2025 DEFINITION Whi4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010057 VERSION NP_010057.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180284.1 REFERENCE 1 (residues 1 to 649) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 649) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 649) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 649) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11641. Method: conceptual translation. FEATURES Location/Qualifiers source 1..649 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..649 /product="Whi4p" /calculated_mol_wt="70559" Region 531..624 /region_name="RRM_scw1_like" /note="RNA recognition motif (RRM) found in yeast cell wall integrity protein scw1 and similar proteins; cd12245" /db_xref="CDD:409691" CDS 1..649 /gene="WHI4" /locus_tag="YDL224C" /coded_by="NM_001180284.1:1..1950" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0008361 regulation of cell size [PMID:11290704]" /experiment="EXISTENCE:genetic interaction:GO:0061157 mRNA destabilization [PMID:24386402]" /note="Putative RNA binding protein; regulates the cell size requirement for passage through Start and commitment to cell division; WHI4 has a paralog, WHI3, that arose from the whole genome duplication" /db_xref="GeneID:851302" /db_xref="SGD:S000002383" ORIGIN 1 mslvhnqtnl neskfliera fssssetvpl skeatypmpt aysfsavrsn setnikrenp 61 qgfakepimt smlhnltmst gkgngndvns laphdvdvgp yclllrnlpk ditlrecyci 121 fslatgvssi elkrddrepf ndnekvvvvk fgslslvthy anilnsksei fgpsfpfrsh 181 idvvneqtql pvsfqehvss gttnsspkny qlsssaqnei qnqsfntisy gktsssplgp 241 saakprpsll serslrfsfn dpfgletisq rkesvpflrn sisqhdlsnv tttpvpagmp 301 pqkdagksll llekdeines iwngdelvnd vgnssfgasl qeppmsstpv mewnasstan 361 iplfqlssqe nhqsnllpps hhsisqdvph iqsqpnlnns gvihsatslp hyhllnqina 421 stktqsiqqs vsnvpsnldl nlqtenghpq ssapngssif nnqkvnqgfl vseqdtstis 481 rqkecsstas asafsknnet nvagsttisq adlsllakvp ppanpadqnp pcntlyvgnl 541 ppdateqelr qlfsnqqgfr rlsfrnkmns hghgnghghg picfvefedv sfatralael 601 ygsqlphprp slnnkggirl sfsknplgvr gsnsrsksgy sfngsygks // LOCUS NP_010058 1046 aa linear PLN 30-JUN-2025 DEFINITION Hbt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010058 VERSION NP_010058.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180283.1 REFERENCE 1 (residues 1 to 1046) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1046) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1046) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1046) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1046) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1046) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1046) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1046) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1046) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11642. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1046 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1046 /product="Hbt1p" /calculated_mol_wt="113485" Region <168..>343 /region_name="ser_rich_anae_1" /note="serine-rich protein; NF033849" /db_xref="CDD:468206" CDS 1..1046 /gene="HBT1" /locus_tag="YDL223C" /coded_by="NM_001180283.1:1..3141" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005937 mating projection [PMID:11923536]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:11923536]" /note="Shmoo tip protein, substrate of Hub1p ubiquitin-like protein; mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis; HBT1 has a paralog, YNL195C, that arose from the whole genome duplication" /db_xref="GeneID:851303" /db_xref="SGD:S000002382" ORIGIN 1 mnmnesiskd gqgeeeqnnf sfggkpgsyd snsdsaqrkk sfsttkptey nlpkeqpest 61 sknletkakn illpwrkkhn kdsetphedt eadanrranv tsdvnpvsad tksssgpnat 121 itthgysyvk tttpaatseq skvktsppts hehsnikasp tahrhskgda ghpsiatthn 181 hstskaatsp vththghssa ttspvththg hasvkttspt nthehskant gpsatatthg 241 hinvktthpv shghsgsstg pkstaaaqdh sstktnpsvt hghtsvkdns satkgysntd 301 snsdrdvipg sfrgmtgtdv npvdpsvyts tgpksnvssg mnavdpsvyt dtssksadrr 361 kysgntatgp pqdtikeiaq nvkmdeseqt glkndqvsgs daiqqqtmep epkaavgtsg 421 fvsqqpsyhd snkniqhpek nkvdnknise raaekfnier ddilesaddy qqkniksktd 481 snwgpieyss sagknknlqd vvipssmkek fdsgtsgsqn mpkagtelgh mkyndngrdn 541 lqyvagsqag sqntnnnidm sprheaewsg lsndattrnn vvspamkded mnedstkphq 601 ygldylddve dyhendiddy snakkndlys kkayqgkpsd ynyeqrekip gtfepdtlsk 661 svqkqdedpl sprqttnrag metardeslg nyeysntsgn kklsdlsknk sgptptrsnf 721 idqieprrak ttqdiasdak dftnnpetgt tgnvdttgrm gaksktfssn pfddskntdt 781 hlenanvaaf dnsrsgdtty sksgdaetaa ydniknadpt yaksqditgm thdqepsseq 841 kasygsggns qnqeyssddn idvnknakvl eedapgykre vdlknkrrtd lggadasnay 901 aaevgnfpsl idphvptygf kdtntsssqk psegtypett sysihnetts qgrkvsvgsm 961 gsgkskhhhn hhrhsrqnss kgsdydynns thsaehtprh hqygsdegeq dyhddeqgee 1021 qagkqsfmgr vrksisggtf gfrsei // LOCUS NP_010059 309 aa linear PLN 30-JUN-2025 DEFINITION Fmp45p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010059 VERSION NP_010059.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180282.1 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11643. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..309 /product="Fmp45p" /calculated_mol_wt="34004" Region 22..205 /region_name="SUR7" /note="SUR7/PalI family; pfam06687" /db_xref="CDD:399580" CDS 1..309 /gene="FMP45" /locus_tag="YDL222C" /coded_by="NM_001180282.1:1..930" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11784867]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11784867]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:11784867]" /note="Integral membrane protein localized to mitochondria; required for sporulation and maintaining sphingolipid content; similar to SUR7; FMP45 has a paralog, YNL194C, that arose from the whole genome duplication" /db_xref="GeneID:851304" /db_xref="SGD:S000002381" ORIGIN 1 mifkrfvnll vflfllgagl ltfflilsgg resgtlknfy wlqadtngfn sapsttrwyn 61 ynwcgyedgq lancssrapa kpfsprdnfg nsvnlpssfr nnrdtyyyls rvgwamllis 121 lffivlalvp gflatflpfk avpvlycvls wlafffiila aclytgcyvk arktfrnsgr 181 sarlgpknfa fiwtsvflml vnaiwstifs athkahstys dhdmyaqyes psvdtgaqme 241 kstynsgatd gagpitaapv vgqpqptttt tpagngkffq klktrkqvps aelepagdgg 301 lagpvtvrd // LOCUS NP_010061 924 aa linear PLN 30-JUN-2025 DEFINITION telomere-binding protein CDC13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010061 VERSION NP_010061.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180280.1 REFERENCE 1 (residues 1 to 924) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 924) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 924) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 924) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 924) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 924) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 924) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 924) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 924) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11644. Method: conceptual translation. FEATURES Location/Qualifiers source 1..924 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..924 /product="telomere-binding protein CDC13" /calculated_mol_wt="104773" Region 14..241 /region_name="CDC13_N" /note="Cell division control protein 13 N-terminus; pfam16853" /db_xref="CDD:407096" Region 359..471 /region_name="Cdc13_OB2" /note="Cell division control protein 13, OB2 domain; pfam18691" /db_xref="CDD:408468" Region 510..665 /region_name="Telo_bind" /note="Telomeric single stranded DNA binding POT1/CDC13; smart00976" /db_xref="CDD:214949" Region 754..871 /region_name="Cdc13_OB4_dimer" /note="Cdc13 OB4 dimerization domain; pfam18233" /db_xref="CDD:436358" CDS 1..924 /gene="CDC13" /locus_tag="YDL220C" /gene_synonym="EST4" /coded_by="NM_001180280.1:1..2775" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:26966248|PMID:9710643]" /experiment="EXISTENCE:direct assay:GO:0010521 telomerase inhibitor activity [PMID:19043074]" /experiment="EXISTENCE:direct assay:GO:0032210 regulation of telomere maintenance via telomerase [PMID:27659693]" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:8943008|PMID:8824190|PMID:17166094]" /experiment="EXISTENCE:direct assay:GO:0061770 translation elongation factor binding [PMID:31006804]" /experiment="EXISTENCE:genetic interaction:GO:0007004 telomere maintenance via telomerase [PMID:11239396]" /experiment="EXISTENCE:genetic interaction:GO:0032210 regulation of telomere maintenance via telomerase [PMID:11046137]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:11390652]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:8978029]" /experiment="EXISTENCE:mutant phenotype:GO:0016233 telomere capping [PMID:7565765]" /experiment="EXISTENCE:mutant phenotype:GO:0043047 single-stranded telomeric DNA binding [PMID:17166094]" /experiment="EXISTENCE:mutant phenotype:GO:0071166 ribonucleoprotein complex localization [PMID:25387524]" /experiment="EXISTENCE:physical interaction:GO:1990879 CST complex [PMID:11230140]" /note="Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles regulating telomerase, telomere end protection, and telomere replication; can dynamically intermolecularly exchange between telomeric single-stranded DNA molecules; essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle" /db_xref="GeneID:851306" /db_xref="SGD:S000002379" ORIGIN 1 mdtleepecp phknrifvss skdfegypsk aivpvqfval ltsihltetk cllgfsnfer 61 rgdqsqedqy liklkfkdrg serlaritis llcqyfdiel pdldsdsgas ptvilrdihl 121 erlcfsscka lyvskhgnyt lfledikpld lvsvistist kstnsskhss selisecdln 181 nslvdifnnl iemnrdeknr fkfvklihyd ielkkfvqdq qkvlsqkska aainpffvpn 241 rlgipyiesq nefnsqlmtl nvdepttdis nmgeemhdsa dpiedsdsst tsstgkyfss 301 ksyiqsqtpe rktsvpnnwh dddsgskrkr klsfhspnas sirkaisyeq lslasvgsve 361 rlegkivgmn ppqfasinef kyctlklyft qllpnvpdkv lvpgvnciei viptrerice 421 lfgvlncqsd kisdilllek pdrisvever ilwdndktas pgmavwslkn istdtqaqaq 481 vqvpaqssas idpsrtrmsk markdptief cqlgldtfet kyitmfgmlv scsfdkpafi 541 sfvfsdftkn divqnylydr ylidyenkle lnegfkaimy knqfetfdsk lrkifnnglr 601 dlqngrdenl sqygivckmn ikvkmyngkl naivrecepv phsqissias psqcehlrlf 661 yqrafkrige saisryfeey rrffpihrng shlaklrfde vkhepkkspt tpalaehipd 721 lnadvssfdv kftdisslld ssarlprpqq thksntlysc egriiaieyh asdlcfhitn 781 elpllqtrgl apervlqlhi itsknfayff nrssaylqrq pleekytqla qflghsfkfn 841 itssltlfpd ttvalqiwcp iectfrelqq qlahpkvaaa pdsgsldcai natvnplrll 901 aaqngvtvkk eedndddaga vpts // LOCUS NP_010062 150 aa linear PLN 30-JUN-2025 DEFINITION D-tyrosyl-tRNA(Tyr) deacylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010062 VERSION NP_010062.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180279.1 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11645. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..150 /product="D-tyrosyl-tRNA(Tyr) deacylase" /EC_number="3.1.1.96" /calculated_mol_wt="16614" Region 1..148 /region_name="Dtyr_deacylase" /note="D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; cl00253" /db_xref="CDD:469690" Site order(7,78..82,94,144) /site_type="active" /note="putative active site [active]" /db_xref="CDD:238316" Site order(44,47..49,51..54,78..79,81..82,84..86,88..92,94, 130..147) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:238316" Site order(48,53,88,91) /site_type="other" /note="putative tRNAtyr binding site [nucleotide binding]" /db_xref="CDD:238316" CDS 1..150 /gene="DTD1" /locus_tag="YDL219W" /coded_by="NM_001180279.1:1..453" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006399 tRNA metabolic process [PMID:10918062]" /experiment="EXISTENCE:mutant phenotype:GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity [PMID:10766779]" /experiment="EXISTENCE:mutant phenotype:GO:0097358 D-leucyl-tRNA(Leu) deacylase activity [PMID:10918062]" /experiment="EXISTENCE:mutant phenotype:GO:1900829 D-tyrosine catabolic process [PMID:10918062]" /experiment="EXISTENCE:mutant phenotype:GO:1900832 D-leucine catabolic process [PMID:10918062]" /note="D-Tyr-tRNA(Tyr) deacylase; functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes" /db_xref="GeneID:851307" /db_xref="SGD:S000002378" ORIGIN 1 mkivlqkvsq asvvvdskvi ssikhgymll vgisiddsma eidklskkvl slrifedesr 61 nlwkknikea ngeilsvsqf tlmaktkkgt kpdfhlaqkg hiakelyeef lkllrsdlge 121 ekvkdgefga mmscsltneg pvtiildsdq // LOCUS NP_010063 317 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL218W [Saccharomyces cerevisiae S288C]. ACCESSION NP_010063 VERSION NP_010063.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180278.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11646. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..317 /product="uncharacterized protein" /calculated_mol_wt="34319" Region 9..151 /region_name="MARVEL" /note="Membrane-associating domain; pfam01284" /db_xref="CDD:366555" CDS 1..317 /locus_tag="YDL218W" /coded_by="NM_001180278.1:1..954" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /note="hypothetical protein; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin" /db_xref="GeneID:851308" /db_xref="SGD:S000002377" ORIGIN 1 mkrvtgvflt llrfsqfass vlvmsllaya ihaygnrgnk ktnftlatgv isvfylialg 61 ilclalptli yigmyfcael ivcmlwlaaf vvlakaqger scsntnadgl yynpysgqyt 121 adshrracns sqaaiafsgl cfvlflisvi llginvltpi rkryqtqgmw rsgasmgtkl 181 hrwsglalse pfeetaaydn tnvrtgdvea gagdnaayts epngdaryat ndpngqyhtt 241 ttntrytttt adpktryttn drnpgsanva nsavdqhays tdesgdrsyq ekvtegahsg 301 amsgstaepn rnvnqmp // LOCUS NP_010064 207 aa linear PLN 30-JUN-2025 DEFINITION translocation channel protein TIM22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010064 VERSION NP_010064.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180277.1 REFERENCE 1 (residues 1 to 207) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 207) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 207) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 207) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11647. Method: conceptual translation. FEATURES Location/Qualifiers source 1..207 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..207 /product="translocation channel protein TIM22" /calculated_mol_wt="21733" Region 1..197 /region_name="TIM22" /note="Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones]; COG5596" /db_xref="CDD:227883" CDS 1..207 /gene="TIM22" /locus_tag="YDL217C" /coded_by="NM_001180277.1:1..624" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:32591483]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:32591483]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:11864609]" /experiment="EXISTENCE:direct assay:GO:0030943 mitochondrion targeting sequence binding [PMID:11864609]" /experiment="EXISTENCE:direct assay:GO:0042721 TIM22 mitochondrial import inner membrane insertion complex [PMID:10648604|PMID:10637294]" /experiment="EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:32591483]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:32591483]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:32591483|PMID:10648604|PMID:8955274]" /note="Essential core component of mitochondrial TIM22 complex; involved in insertion of polytopic proteins into inner membrane; forms channel through which proteins are imported; different regions of Tim22p have functionally diverse roles in recruiting partner subunits to core channel" /db_xref="GeneID:851309" /db_xref="SGD:S000002376" ORIGIN 1 mvytgfgleq ispaqkkpyn eltpeeqger gaemimnfmt scpgksvvsg vtgfalggvl 61 glfmasmayd tplhtptpan taatatagni gvggisrtvq qisdlpfrqq mklqftdmgk 121 ksyssaknfg yigmiyagve cvieslrakn diyngvtagf ftgaglayka gpqaalmgga 181 gfaafsaaid lymksedgrp pqndfke // LOCUS NP_010065 440 aa linear PLN 30-JUN-2025 DEFINITION COP9 signalosome catalytic subunit RRI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010065 VERSION NP_010065.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180276.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11648. On Apr 21, 2006 this sequence version replaced NP_010065.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..440 /product="COP9 signalosome catalytic subunit RRI1" /calculated_mol_wt="50681" Region 62..346 /region_name="MPN_RPN11_CSN5" /note="Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5; cd08069" /db_xref="CDD:163700" Site order(92,164,166,174,177) /site_type="active" /note="MPN+ (JAMM) motif [active]" /db_xref="CDD:163700" Site order(164,166,177) /site_type="other" /note="Zinc-binding site [ion binding]" /db_xref="CDD:163700" CDS 1..440 /gene="RRI1" /locus_tag="YDL216C" /gene_synonym="CSN5; JAB1" /coded_by="NM_001180276.1:1..1323" /experiment="EXISTENCE:direct assay:GO:0008180 COP9 signalosome [PMID:12446563]" /experiment="EXISTENCE:mutant phenotype:GO:0000338 protein deneddylation [PMID:24164706|PMID:12446563|PMID:12186635]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:12446563]" /experiment="EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:12183637]" /experiment="EXISTENCE:mutant phenotype:GO:0070452 positive regulation of ergosterol biosynthetic process [PMID:24164706]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:12446563]" /note="Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; involved in modulation of genes controlling amino acid and lipid metabolism, and ergosterol biosynthesis" /db_xref="GeneID:851310" /db_xref="SGD:S000002375" ORIGIN 1 mslsnktvke lrqllkeryt vedeltesia lssmrfkpsq epefhalsqs sllktklkqq 61 sstdipsyth vlisklscek ithyavrggn ieimgilmgf tlkdnivvmd cfnlpvvgte 121 trvnaqlesy eymvqyidem ynhndggdgr dykgaklnvv gwfhshpgyd cwlsnidiqt 181 qdlnqrfqdp yvaivvdplk sledkilrmg afrtiesksd dnsatsyyel etiifdseln 241 ralfetklnl hcvieddese qislnrlids mkqysylmds knvrtrikla ttservsnen 301 kknidyqnrs trsqfclntq rgdstetssf gsmfsgdnts dvdmedrnlt efdstdtslc 361 ingepsihvn rverssrstd nfhnskkrmn snqerchdeg ndmlqrnvle tdyaraknri 421 laskikqyer lrfykdtftl // LOCUS NP_010066 1092 aa linear PLN 30-JUN-2025 DEFINITION glutamate dehydrogenase (NAD(+)) [Saccharomyces cerevisiae S288C]. ACCESSION NP_010066 VERSION NP_010066.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180275.1 REFERENCE 1 (residues 1 to 1092) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1092) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1092) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1092) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11649. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1092 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1092 /product="glutamate dehydrogenase (NAD(+))" /EC_number="1.4.1.2" /calculated_mol_wt="124202" Region 41..1092 /region_name="Bac_GDH" /note="Bacterial NAD-glutamate dehydrogenase; cl29306" /db_xref="CDD:452960" CDS 1..1092 /gene="GDH2" /locus_tag="YDL215C" /coded_by="NM_001180275.1:1..3279" /experiment="EXISTENCE:direct assay:GO:0004352 glutamate dehydrogenase (NAD+) activity [PMID:6343120]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:6343120]" /experiment="EXISTENCE:direct assay:GO:0006538 L-glutamate catabolic process [PMID:6343120]" /experiment="EXISTENCE:mutant phenotype:GO:0004352 glutamate dehydrogenase (NAD+) activity [PMID:1975578]" /experiment="EXISTENCE:mutant phenotype:GO:0006538 L-glutamate catabolic process [PMID:1975578]" /note="NAD(+)-dependent glutamate dehydrogenase; degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels; genetically interacts with GDH3 by suppressing stress-induced apoptosis" /db_xref="GeneID:851311" /db_xref="SGD:S000002374" ORIGIN 1 mlfdnknrga lnslntpdia slsissmsdy hvfdfpgkdl qreevidlld qqgfipddli 61 eqevdwfyns lgiddlffsr espqlisnii hslyaskldf fakskfngiq prlfsiknki 121 itndnhaifm esntgvsisd sqqknfkfas davgndtleh gkdtikknri emddscppye 181 ldseiddlfl dnksqkncrl vsfwapesel kltfvyesvy pnddpagvdi ssqdllkgdi 241 esisdktmyk vssnenkkly glllklvker egpvikttrs venkdeirll vaykrfttkr 301 yysalnslfh yyklkpskfy lesfnvkddd iiifsvylne nqqledvllh dveaalkqve 361 reasllyaip nnsfhevyqr rqfspkeaiy ahigaifinh fvnrlgsdyq nllsqitikr 421 ndttlleive nlkrklrnet ltqqtiinim skhytiiskl yknfaqihyy hnstkdmekt 481 lsfqrlekve pfkndqefea ylnkfipnds pdllilktln ifnksilktn ffitrkvais 541 frldpslvmt kfeypetpyg iffvvgntfk gfhirfrdia rggirivcsr nqdiydlnsk 601 nvidenyqla stqqrknkdi peggskgvil lnpglvehdq tfvafsqyvd amidilindp 661 lkenyvnllp keeilffgpd egtagfvdwa tnharvrncp wwksfltgks pslggiphde 721 ygmtslgvra yvnkiyetln ltnstvykfq tggpdgdlgs neillsspne cylaildgsg 781 vlcdpkgldk delcrlaher kmisdfdtsk lsnngffvsv damdimlpng tivangttfr 841 ntfhtqifkf vdhvdifvpc ggrpnsitln nlhyfvdekt gkckipyive ganlfitqpa 901 knaleehgci lfkdasankg gvtsssmevl aslalndndf vhkfigdvsg ersalyksyv 961 vevqsriqkn aelefgqlwn lnqlngthis eisnqlsfti nklnddlvas qelwlndlkl 1021 rnyllldkii pkilidvagp qsvlenipes ylkvllssyl sstfvyqngi dvnigkflef 1081 igglkreaea sa // LOCUS NP_010067 699 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase PRR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010067 VERSION NP_010067.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180274.1 REFERENCE 1 (residues 1 to 699) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 699) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 699) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 699) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11650. Method: conceptual translation. FEATURES Location/Qualifiers source 1..699 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..699 /product="serine/threonine protein kinase PRR2" /EC_number="2.7.11.1" /calculated_mol_wt="78808" Region 367..653 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(367..370,373,375,388,390,424,440..443,484,488..489, 491,501..502) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..699 /gene="PRR2" /locus_tag="YDL214C" /coded_by="NM_001180274.1:1..2100" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11337509]" /experiment="EXISTENCE:genetic interaction:GO:0031138 negative regulation of conjugation with cellular fusion [PMID:11337509]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11337509]" /experiment="EXISTENCE:mutant phenotype:GO:0031138 negative regulation of conjugation with cellular fusion [PMID:11337509]" /note="Serine/threonine protein kinase; inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance; PRR2 has a paralog, NPR1, that arose from the whole genome duplication" /db_xref="GeneID:851312" /db_xref="SGD:S000002373" ORIGIN 1 mslsrilryn qrnnkttasl taehaysdnw aysvslgdpt svgvnmaakt gealnksyds 61 vfsslpvads vprtdftass rddentdvqk lttswmekid tkmpeniski dsniisspmv 121 skvearfivp kgrlrknstd ftssfsnsls lpksygklif ftskknssst kknlandisd 181 nkhnnnssnt ighnipvtta tatcdeiact steheynvye eermfttrvy sledsvssls 241 tnplddtyse avqvntrhie dtestahirk hsyttslssi krlfkitsfs nnnsnscdhq 301 estvaddcai ssslkettss pvstgsfslm ienedsdrdq iiqalysnie astdlvsrky 361 rdldvvlgeg sggkvklvqr vldnkvfalk eyrskkkres erkyikniis eyciastlkn 421 pnicetleil yekgkifqil eyceydlfsl vmsekmhyee icclfkqlin gvkylhdigl 481 shrdlkldnc vvtrrgilkl idfgassvfh yplssqmiea ngivgsdpyl spevfyfney 541 dpraldvwsv giiffcmitr rfpwkypkvk dvqfkafcsg rgvssfkdlv trpatddsnn 601 ydndgyeegv idmgpnfilh rlpeethkim rrilevspfr ritingilqd gwikeietcq 661 vvgaaspnea slriinkgnh ihtnidqrya higglhqrt // LOCUS NP_010068 225 aa linear PLN 30-JUN-2025 DEFINITION Nop6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010068 VERSION NP_010068.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180273.1 REFERENCE 1 (residues 1 to 225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 225) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11651. Method: conceptual translation. FEATURES Location/Qualifiers source 1..225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..225 /product="Nop6p" /calculated_mol_wt="25085" Region <1..55 /region_name="NatA_aux_su" /note="N-terminal acetyltransferase A, auxiliary subunit; pfam12569" /db_xref="CDD:463630" Region 78..151 /region_name="RRM_Nop6" /note="RNA recognition motif (RRM) found in Saccharomyces cerevisiae nucleolar protein 6 (Nop6) and similar proteins; cd12400" /db_xref="CDD:409834" CDS 1..225 /gene="NOP6" /locus_tag="YDL213C" /coded_by="NM_001180273.1:1..678" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:17425675|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:21282979]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:21893585]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:21282979]" /experiment="EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:17425675]" /note="rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM); hydrophilin essential to overcome the stress of the desiccation-rehydration process; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes" /db_xref="GeneID:851313" /db_xref="SGD:S000002372" ORIGIN 1 mgseedkklt kkqlkaqqfr kskeekdqek dvkkeqapeg krpnsaagnd geepvkkkrk 61 trrgrggkgk ngkkgnrfiv fvgslprdit avelqnhfkn sspdqirlra dkgiaflefd 121 adkdrtgiqr rmdiallqhg tllkekkinv eltvggggns qerleklknk nikldeerke 181 rltkmindgn qkkiakttat aaqtsgtdnk pvpagihpdr akllk // LOCUS NP_010069 210 aa linear PLN 30-JUN-2025 DEFINITION Shr3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010069 VERSION NP_010069.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180272.1 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11652. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..210 /product="Shr3p" /calculated_mol_wt="23381" Region 6..188 /region_name="SHR3_chaperone" /note="ER membrane protein SH3; pfam08229" /db_xref="CDD:369769" CDS 1..210 /gene="SHR3" /locus_tag="YDL212W" /gene_synonym="APF1" /coded_by="NM_001180272.1:1..633" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:1423607|PMID:15623581]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0090114 COPII-coated vesicle budding [PMID:10564255]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15623581]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:15623581|PMID:10564255]" /note="Endoplasmic reticulum packaging chaperone; required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface" /db_xref="GeneID:851314" /db_xref="SGD:S000002371" ORIGIN 1 mfsysdfcsi gtamilsatt flmgvffsnm pydyhllfnp nstqehfdla lrhyqilhet 61 plpvivtlcv vagiglvggt ikvfkpnpel qmfeycslgl yvlaicvflt nvktgidcsv 121 shnwgevten qglaviassn iillvmfagv iilqiglwys nwdlqkrlke fyaqeereaa 181 nagkktekvd nakkndnksk gaqkrknakk // LOCUS NP_010070 372 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL211C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010070 VERSION NP_010070.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180271.1 REFERENCE 1 (residues 1 to 372) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 372) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 372) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 372) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11653. Method: conceptual translation. FEATURES Location/Qualifiers source 1..372 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..372 /product="uncharacterized protein" /calculated_mol_wt="40621" CDS 1..372 /locus_tag="YDL211C" /coded_by="NM_001180271.1:1..1119" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YDL211C has a paralog, TDA7, that arose from the whole genome duplication" /db_xref="GeneID:851315" /db_xref="SGD:S000002370" ORIGIN 1 mllnvtssqy istpqsrsls eidtsetasl ssatdhifal stevvssitt nlieglessi 61 qvpistaygt tsfrnntssp qylvsnctss vqsnitidrg llstlktftt sqvptiepst 121 tklttplstt ftststseiy svftsensvy iiydqeykft ersttfnthf pqttvlqesn 181 ppltftipsn titgdaklyq ylsgalntqd tsdannrrtg vivgstvgvv igvvivifig 241 fiiirnrrnv knhskkgfsh digkrvscde vteteapsnp flnvlnykvt tngegkrdsf 301 engrdlhras ssdgiyiahp yygmadhesg rfsyvssyne saessieets ssastitrpn 361 iqqtnsflre ii // LOCUS NP_010071 571 aa linear PLN 30-JUN-2025 DEFINITION Uga4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010071 VERSION NP_010071.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180270.1 REFERENCE 1 (residues 1 to 571) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 571) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 571) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 571) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11654. Method: conceptual translation. FEATURES Location/Qualifiers source 1..571 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..571 /product="Uga4p" /calculated_mol_wt="61742" Region 61..529 /region_name="AA_permease_2" /note="Amino acid permease; cl45918" /db_xref="CDD:459263" CDS 1..571 /gene="UGA4" /locus_tag="YDL210W" /coded_by="NM_001180270.1:1..1716" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14985124|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015495 gamma-aminobutyric acid:proton symporter activity [PMID:8455553]" /experiment="EXISTENCE:genetic interaction:GO:0015812 gamma-aminobutyric acid transport [PMID:8455553]" /experiment="EXISTENCE:genetic interaction:GO:0055085 transmembrane transport [PMID:8455553]" /experiment="EXISTENCE:mutant phenotype:GO:0015489 putrescine transmembrane transporter activity [PMID:14985124]" /experiment="EXISTENCE:mutant phenotype:GO:0015812 gamma-aminobutyric acid transport [PMID:14985124]" /experiment="EXISTENCE:mutant phenotype:GO:0015847 putrescine transport [PMID:14985124]" /note="GABA (gamma-aminobutyrate) permease; serves as a GABA transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane" /db_xref="GeneID:851317" /db_xref="SGD:S000002369" ORIGIN 1 msmssknenk isveqristd igqayqlqgl gsnlrsirsk tgagevnyid aaksvndnql 61 laeigykqel krqfstlqvf giafsimgll psiasvmggg lgggpatlvw gwfvaaffil 121 lvgitmaeha ssiptaggly ywtyyyapeg ykeiisfiig csnslalaag vcsidyglae 181 eiaaavtltk dgnfevtsgk lygifagavv vmcictcvas gaiarlqtls ifanlfiivl 241 lfialpigtk hrmggfndgd fifgkyenls dwnngwqfcl agfmpavwti gsfdscvhqs 301 eeakdakksv pigiissiav cwilgwliii clmacinpdi dsvldskygf alaqiiydsl 361 gkkwaiafms liafcqflmg asittavsrq vwafsrdngl plskyikrvd skysvpffai 421 laacvgslil gllcliddaa tdalfslava gnnlawstpt vfrltsgrdl frpgpfylgk 481 iwspivawtg vafqlfiiil vmfpsqqhgi tkstmnyacv igpgiwilag iyykvykkky 541 yhgpatnlsd ddyteavgad vidtimskqe p // LOCUS NP_010072 339 aa linear PLN 30-JUN-2025 DEFINITION active spliceosome conformation promoter CWC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010072 VERSION NP_010072.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180269.1 REFERENCE 1 (residues 1 to 339) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 339) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 339) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 339) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11655. Method: conceptual translation. FEATURES Location/Qualifiers source 1..339 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..339 /product="active spliceosome conformation promoter CWC2" /calculated_mol_wt="38300" Region 4..114 /region_name="Torus" /note="Torus domain; pfam16131" /db_xref="CDD:435160" Region 134..227 /region_name="RRM_cwf2" /note="RNA recognition motif (RRM) found in yeast pre-mRNA-splicing factor Cwc2 and similar proteins; cd12360" /db_xref="CDD:409795" CDS 1..339 /gene="CWC2" /locus_tag="YDL209C" /gene_synonym="NTC40" /coded_by="NM_001180269.1:1..1020" /experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:19435883]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:19435883]" /experiment="EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:19435883]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:12088152]" /experiment="EXISTENCE:physical interaction:GO:0000974 Prp19 complex [PMID:12088152]" /note="Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2" /db_xref="GeneID:851318" /db_xref="SGD:S000002368" ORIGIN 1 mtswrdksak vqvkeselps sipaqtgltf niwynkwsqg fagntrfvsp falqpqlhsg 61 ktrgdndgql ffclffakgm cclgpkceyl hhipdeedig klalrtevld cfgrekfady 121 redmggigsf rkknktlyvg gidgalnskh lkpaqiesri rfvfsrlgdi driryveskn 181 cgfvkfkyqa naefakeams nqtlllpsdk ewddrregtg llvkwanedp dpaaqkrlqe 241 elkleslnmm vhlinnntns agtevnnknn erldrtfpea svdnvkkrll pldngmesdd 301 fieklkkvkk nisrenissk psvgklggpl ldylssded // LOCUS NP_010073 156 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-binding protein NHP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010073 VERSION NP_010073.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180268.1 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11656. On Nov 30, 2005 this sequence version replaced NP_010073.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..156 /product="snoRNA-binding protein NHP2" /calculated_mol_wt="16991" Region 41..133 /region_name="Ribosomal_L7Ae" /note="Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; pfam01248" /db_xref="CDD:426153" CDS 1..156 /gene="NHP2" /locus_tag="YDL208W" /coded_by="NM_001180268.1:1..471" /experiment="EXISTENCE:direct assay:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]" /experiment="EXISTENCE:direct assay:GO:0034513 box H/ACA snoRNA binding [PMID:11433018]" /experiment="EXISTENCE:mutant phenotype:GO:0000493 box H/ACA snoRNP assembly [PMID:11433018]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9843512]" /experiment="EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:9843512]" /experiment="EXISTENCE:mutant phenotype:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]" /experiment="EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:9843512]" /note="Protein related to mammalian high mobility group (HMG) proteins; nuclear protein; essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing" /db_xref="GeneID:851319" /db_xref="SGD:S000002367" ORIGIN 1 mgkdnkehke skesktvdny earmpavlpf akplaskkln kkvlktvkka skaknvkrgv 61 kevvkalrkg ekglvviagd ispadvishi pvlcedhsvp yifipskqdl gaagatkrpt 121 svvfivpgsn kkkdgknkee eykesfnevv kevqal // LOCUS NP_010074 538 aa linear PLN 30-JUN-2025 DEFINITION nucleoporin GLE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010074 VERSION NP_010074.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180267.1 REFERENCE 1 (residues 1 to 538) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 538) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 538) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 538) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11657. Method: conceptual translation. FEATURES Location/Qualifiers source 1..538 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..538 /product="nucleoporin GLE1" /calculated_mol_wt="61942" Region 273..499 /region_name="GLE1" /note="GLE1-like protein; pfam07817" /db_xref="CDD:462280" CDS 1..538 /gene="GLE1" /locus_tag="YDL207W" /gene_synonym="BRR3; NLE2; RSS1" /coded_by="NM_001180267.1:1..1617" /experiment="EXISTENCE:direct assay:GO:0000822 inositol hexakisphosphate binding [PMID:16783363]" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17897934]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:15459192|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10610322]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006409 tRNA export from nucleus [PMID:31453808]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:16783364]" /experiment="EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:10610322]" /experiment="EXISTENCE:genetic interaction:GO:0008047 enzyme activator activity [PMID:16783364]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:20371601]" /experiment="EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:18724935]" /experiment="EXISTENCE:mutant phenotype:GO:0006449 regulation of translational termination [PMID:20371601]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:16783364]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:8898365|PMID:27385342]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:18724935]" /note="Cytoplasmic nucleoporin required for polyadenylated mRNA export; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export; mediates translation initiation; required for efficient translation termination" /db_xref="GeneID:851320" /db_xref="SGD:S000002366" ORIGIN 1 mrfvfdevfn sdtdspefee tcsttsstss qcptpepspa iklpsftkvg tkklvnesvv 61 ildpalenal rdlnlqskli pinepivaas siivphstnm plprashssl ldnaknsnat 121 aplleaiees fqrkmqnlvl anqkeiqsir enkrrveeqr krkeeeerkr keaeekakre 181 qellrqkkde eerkrkeaea klaqqkqeee rkkieeqnek erqlkkehea kllqqkdklg 241 kavtnfdkis kmfwhykdki aqikqdivlp ikkadvnvrn llsrhkrkin pkfgqltnsn 301 qqlfkiqnel tqlindtkgd slayhwilnf iakavvhqae tevrvkpesa lplgkltlyl 361 lvqfpelqel fmarlvkkcp fvigftceid tekgrqnmgw krnnenkwed ntsydermgg 421 ilslfaiitr lqlpqefitt tshpfpials whilaricnt plnlitnthf vilgswwdaa 481 avqflqaygn qaskllilig eeltsrmaek kyvgaarlri lleawqnnnm esfpemsp // LOCUS NP_010075 762 aa linear PLN 30-JUN-2025 DEFINITION Ycx1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010075 VERSION NP_010075.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180266.1 REFERENCE 1 (residues 1 to 762) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 762) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 762) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 762) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11658. Method: conceptual translation. FEATURES Location/Qualifiers source 1..762 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..762 /product="Ycx1p" /calculated_mol_wt="85853" Region 37..200 /region_name="Na_Ca_ex" /note="Sodium/calcium exchanger protein; pfam01699" /db_xref="CDD:426387" Region 591..756 /region_name="Na_Ca_ex" /note="Sodium/calcium exchanger protein; pfam01699" /db_xref="CDD:426387" CDS 1..762 /gene="YCX1" /locus_tag="YDL206W" /coded_by="NM_001180266.1:1..2289" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:36965615]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:36965615]" /experiment="EXISTENCE:mutant phenotype:GO:0097720 calcineurin-mediated signaling [PMID:36965615]" /note="Protein involved in calcium-induced activation of calcineurin; homologous to proteins in Candida and Cryptococcus; YCX1 is not an essential protein" /db_xref="GeneID:851321" /db_xref="SGD:S000002365" ORIGIN 1 mhkplrwlit iafyvsnvil igyslssngs isefylhsvv liecfsllgv vtsdcltpsl 61 syissnifhi sdrvsgmtll algnalpdit styqsmksgv tslaigelfg gifflltvvi 121 glmgcvatiq fqhdksiety teesfdqnls ydrsnyildv giftfmllvs gtfladgrly 181 fwecivmvlt ycccavylik sykypceind alereveikk tvlannhitv pnrftlttts 241 ditstddgir yvrplgdtqi dednaisldp trlpsksldn isrfnqgipe rrdlirrrir 301 gylrshyhgw vrmtlqdlln iwekqnlfnn tvkslslpsd dthlftkasl deegrplirk 361 rmnslqpkdf ykylslrnge nsnaldtais apqneyqtyy neptslfltv pqkktskksl 421 scdripnlvr snniilndea trtqestnal nsisdvidns llqyerddii ldrtlslcst 481 ksrtawhsfq lynyltdvsl eigffeflsl lvttpvsiil ylsipseisq tdhdlplsyl 541 qniqliaspi ilnqlitnnf sfwllilslv iaillyfktr tipnkfnsdi iftvafllsl 601 aclskavhii vvtlthwinv fnisetilgl tiftwgnsig dlvsnitfvk igvleiaiga 661 cfgspllyfl fgvgfdgimi mlgdktgkiv sgrdsnilmh hidfkvdknl intgvgilia 721 fliftvlipl ndwkidkkis ialltlyivv tcisvflevh qv // LOCUS NP_010076 327 aa linear PLN 30-JUN-2025 DEFINITION hydroxymethylbilane synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010076 VERSION NP_010076.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180265.1 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11659. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..327 /product="hydroxymethylbilane synthase" /EC_number="2.5.1.61" /calculated_mol_wt="36544" Region 5..291 /region_name="PBP2_HuPBGD_like" /note="Human porphobilinogen deaminase possess type 2 periplasmic binding protein fold; cd13645" /db_xref="CDD:270363" Site order(11,15,62,87..88,134..136,138..139,155..159,162,204, 251) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:270363" Site order(105,184,193,195,261..262) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:270363" CDS 1..327 /gene="HEM3" /locus_tag="YDL205C" /gene_synonym="OLE2" /coded_by="NM_001180265.1:1..984" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004418 hydroxymethylbilane synthase activity [PMID:323256|PMID:1508149]" /experiment="EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:14559249|PMID:323256]" /note="Porphobilinogen deaminase; catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme; human homolog HMBS can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid" /db_xref="GeneID:851322" /db_xref="SGD:S000002364" ORIGIN 1 mgpetlhigg rksklaviqs nhvlklieek ypdydckvft lqtlgdqiqf kplysfggka 61 lwtkeledhl yhddpskkld livhslkdmp tllpegfelg gitkrvdptd clvmpfysay 121 kslddlpdgg ivgtssvrrs aqlkrkyphl kfesvrgniq trlqklddpk spyqciilas 181 aglmrmglen ritqrfhsdt myhavgqgal gieirkgdtk mmkildeicd lnaticclse 241 ralmrtlegg csvpigvesk yneetkklll kaivvdvegt eavedeieml ienvkedsma 301 cgkilaermi adgakkilde inldrik // LOCUS NP_001418066 50 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL204W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001418066 VERSION NP_001418066.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001431137.1 REFERENCE 1 (residues 1 to 50) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 50) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 50) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 50) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DBA54437. Method: conceptual translation. FEATURES Location/Qualifiers source 1..50 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..50 /product="uncharacterized protein" /calculated_mol_wt="5671" CDS 1..50 /locus_tag="YDL204W-A" /coded_by="NM_001431137.1:1..153" /note="hypothetical protein, translated but not conserved; translation inhibition causes strong growth phenotypes" /db_xref="GeneID:91000621" /db_xref="SGD:S000350094" ORIGIN 1 mlygnccvkm vknpglpyer qckddcisqk diftpgaare qnnyekwtqs // LOCUS NP_010077 393 aa linear PLN 30-JUN-2025 DEFINITION Rtn2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010077 VERSION NP_010077.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180264.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11660. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..393 /product="Rtn2p" /calculated_mol_wt="44228" Region 33..188 /region_name="Reticulon" /note="pfam02453" /db_xref="CDD:460562" CDS 1..393 /gene="RTN2" /locus_tag="YDL204W" /coded_by="NM_001180264.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:17905927]" /experiment="EXISTENCE:direct assay:GO:0071782 endoplasmic reticulum tubular network [PMID:16469703]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0032581 ER-dependent peroxisome organization [PMID:27129769]" /experiment="EXISTENCE:genetic interaction:GO:0034976 response to endoplasmic reticulum stress [PMID:27117666]" /experiment="EXISTENCE:genetic interaction:GO:0048309 endoplasmic reticulum inheritance [PMID:27117666]" /experiment="EXISTENCE:genetic interaction:GO:0071786 endoplasmic reticulum tubular network organization [PMID:18309084|PMID:16469703|PMID:18442980]" /experiment="EXISTENCE:genetic interaction:GO:0071788 endoplasmic reticulum tubular network maintenance [PMID:21502358]" /note="Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Sec6p, Yip3p, and Sbh1p; less abundant than RTN1; member of RTNLA (reticulon-like A) subfamily; protein increases in abundance and relocalizes to plasma membrane upon DNA replication stress" /db_xref="GeneID:851323" /db_xref="SGD:S000002363" ORIGIN 1 mnrntttnkn anlnnsrnan apgeaghqnk tgliywtnps ksgasfaatl vsllilrnvn 61 visvllkigy mvlftsfave lstkvlfdkg vvsrfgmqes pdlvgvlkph idreldrlpa 121 ledrirklvf ahrtrnnfti gvslyflhgl faifsmntvl imttiflytv pliydrkqar 181 idraidrmkd lvihrfhkny nkvvektepy idkiippqtd egsystsisn enksstsqrn 241 ksglsssefd nmndtsasks gkdsystsqy nraeypvsqn enigtlksgk qeiptekdfn 301 nrhenfskpd vktydprtvd ieeelaahqr eleqnlkdgd ynlvgskeip dpitvpaptr 361 httkpaesqs ipiknnetlh ktthglkqkl qha // LOCUS NP_010078 623 aa linear PLN 30-JUN-2025 DEFINITION Ack1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010078 VERSION NP_010078.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180263.1 REFERENCE 1 (residues 1 to 623) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 623) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 623) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 623) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11661. Method: conceptual translation. FEATURES Location/Qualifiers source 1..623 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..623 /product="Ack1p" /calculated_mol_wt="69240" Region 301..330 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 318..361 /region_name="SEL1" /note="Sel1-like repeats; smart00671" /db_xref="CDD:214772" Region 345..374 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 390..420 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region <394..608 /region_name="TPR" /note="TPR repeat [General function prediction only]; COG0790" /db_xref="CDD:440553" Region 428..458 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 515..547 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 556..588 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" CDS 1..623 /gene="ACK1" /locus_tag="YDL203C" /coded_by="NM_001180263.1:1..1872" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0009967 positive regulation of signal transduction [PMID:18806213]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:18806213]" /note="Protein that functions in the cell wall integrity pathway; functions upstream of Pkc1p; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria" /db_xref="GeneID:851324" /db_xref="SGD:S000002362" ORIGIN 1 mvnqgqpqpn lydkhinmfp pararesshk lgnansdrhg lpaqnivpap ypvddsivel 61 tpaipftsps sssslslpls alnftdgnad ggqlgtpvti nsnngmdifn skptgeigya 121 nngtnstgsr yelpfnfsst keslgspavq dasissgnri sesvrdnsap ppyeesesri 181 lqekvyrtee kapirplnnn pvppqkinqp ptgsaktddn gssggedkls syspealafy 241 qvykktitds skftpeiqmq wcetlltyaf nedfisqyni naeklkrslk peemlknqkv 301 ilehsfkvlt klitlkwppa mylmgtlysh qpylpiknkn ivikndekal eyyckaakln 361 nsdacyragv cfeyqrgtss ldpsptkeqc ikkafqyyqh gaevcsnsac myklgmshly 421 glnmqktdvl laikwfdkaa qkgdspqtly elgkiyefsv lppeiqnllf angirkdsql 481 aikyyqqcak dfeyplaqwk lgncyefgdl glpvvakksi ywyskaaaaq pkgnpmamls 541 lsgwyltgap nilkpnnkea fnwalksskc sdgklartef algfyyekgv gcevdldlak 601 qyyqraarmg frkavdalrs ltn // LOCUS NP_010079 249 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL10m MRPL11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010079 VERSION NP_010079.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180262.1 REFERENCE 1 (residues 1 to 249) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 249) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 249) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 249) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11662. Method: conceptual translation. FEATURES Location/Qualifiers source 1..249 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..249 /product="mitochondrial 54S ribosomal protein uL10m MRPL11" /calculated_mol_wt="28384" Region 48..218 /region_name="Ribosomal_L10" /note="Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; cd05797" /db_xref="CDD:240223" Site order(50..51,54,98..101,104) /site_type="other" /note="23S rRNA interface [nucleotide binding]" /db_xref="CDD:240223" Site order(148,171,174,190,193..194,197..198,200..203,205..206, 208..210,213..214,216..217) /site_type="other" /note="Interface with L7/L12 ribosomal proteins [polypeptide binding]" /db_xref="CDD:240223" CDS 1..249 /gene="MRPL11" /locus_tag="YDL202W" /gene_synonym="uL10m" /coded_by="NM_001180262.1:1..750" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2" /db_xref="GeneID:851325" /db_xref="SGD:S000002361" ORIGIN 1 mlqlrfmpgw vprngffglk etigtvhkrf yalaseqpsr ktvkpldsrk tflidtykhl 61 menssmiffv hynnlskted hhfrfkikqt ggkltkvrnn lfevylrnsh lpdpcgfvkr 121 keqnwkhpll pllkgptati tyedtnpqqv akllkvlqsa qdklmvigak venevlnvek 181 intfktlptk pemqsqlvsv lqmlsglglv rtlenssnal yltlkshndn qkpkedvest 241 tdaeskgsk // LOCUS NP_010080 286 aa linear PLN 30-JUN-2025 DEFINITION tRNA (guanine46-N7)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010080 VERSION NP_010080.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180261.1 REFERENCE 1 (residues 1 to 286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 286) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11663. Method: conceptual translation. FEATURES Location/Qualifiers source 1..286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..286 /product="tRNA (guanine46-N7)-methyltransferase" /EC_number="2.1.1.33" /calculated_mol_wt="33260" Region 77..281 /region_name="TIGR00091" /note="tRNA (guanine-N(7)-)-methyltransferase" /db_xref="CDD:161703" Site order(102..108,126..127,160..162,181) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..286 /gene="TRM8" /locus_tag="YDL201W" /coded_by="NM_001180261.1:1..861" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008176 tRNA (guanine(46)-N7)-methyltransferase activity [PMID:17382321]" /experiment="EXISTENCE:direct assay:GO:0106004 tRNA (guanine-N7)-methylation [PMID:17382321]" /experiment="EXISTENCE:direct assay:GO:0106143 tRNA (m7G46) methyltransferase complex [PMID:18184583|PMID:17382321|PMID:12403464]" /experiment="EXISTENCE:mutant phenotype:GO:0008176 tRNA (guanine(46)-N7)-methyltransferase activity [PMID:12403464]" /experiment="EXISTENCE:mutant phenotype:GO:0106004 tRNA (guanine-N7)-methylation [PMID:12403464]" /note="Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p" /db_xref="GeneID:851326" /db_xref="SGD:S000002360" ORIGIN 1 mkakplsqdp gskryayrin keenrkelkh vkinesslvq egqkidlpkk ryyrqrahsn 61 pfsdhqleyp vspqdmdwsk lypyyknaen gqmtkkvtia digcgfgglm idlspafped 121 lilgmeirvq vtnyvedrii alrnntaskh gfqninvlrg namkflpnff ekgqlskmff 181 cfpdphfkqr khkariitnt llseyayvlk eggvvytitd vkdlhewmvk hleehplfer 241 lskeweende cvkimrnate egkkverkkg dkfvacftrl ptpail // LOCUS NP_010081 188 aa linear PLN 30-JUN-2025 DEFINITION methylated-DNA--protein-cysteine methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010081 VERSION NP_010081.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180260.1 REFERENCE 1 (residues 1 to 188) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 188) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 188) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 188) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11664. On Apr 21, 2006 this sequence version replaced NP_010081.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..188 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..188 /product="methylated-DNA--protein-cysteine methyltransferase" /EC_number="2.1.1.63" /calculated_mol_wt="21368" Region 5..184 /region_name="AdaB" /note="DNA repair enzyme Ada (O6-methylguanine-DNA--protein-cysteine methyltransferase) [Replication, recombination and repair]; COG0350" /db_xref="CDD:440119" Region 99..178 /region_name="ogt" /note="O-6-methylguanine DNA methyltransferase; TIGR00589" /db_xref="CDD:273157" Site order(101..102,120..121,129,132,134..135,137,140..141,143, 151,156,163) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:119438" Site order(120,151..152,154,178) /site_type="active" /db_xref="CDD:119438" CDS 1..188 /gene="MGT1" /locus_tag="YDL200C" /coded_by="NM_001180260.1:1..567" /experiment="EXISTENCE:direct assay:GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity [PMID:2403555|PMID:2065659]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:mutant phenotype:GO:0006307 DNA alkylation repair [PMID:1641326]" /note="DNA repair methyltransferase (6-O-methylguanine-DNA methylase); involved in protection against DNA alkylation damage; localizes to the peroxisome in a Pex5p-dependent manner" /db_xref="GeneID:851327" /db_xref="SGD:S000002359" ORIGIN 1 mkellyytfi etevtgaflv frektqnlvf aslgndklfl lgkvegflkk hekqdtmydl 61 qelkeaetyk ksienyticl enkmplpsga ipfeflfgtd fqrkvwnell nvehghvvty 121 gdiakrigkp taarsvgrac gsnnlallvp chrivgsnrk ltgykwsckl keqllnneke 181 nslslsrl // LOCUS NP_010082 687 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL199C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010082 VERSION NP_010082.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180259.1 REFERENCE 1 (residues 1 to 687) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 687) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 687) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 687) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11665. Method: conceptual translation. FEATURES Location/Qualifiers source 1..687 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..687 /product="uncharacterized protein" /calculated_mol_wt="77371" Region 122..566 /region_name="MFS" /note="Major Facilitator Superfamily; cl28910" /db_xref="CDD:475125" Site order(134..135,138..139,142,177,228..229,231..233,236,257, 260..261,264,379,382..383,386..388,391,420,424,479..480, 484,488,504,507..508,511..512,515) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:349949" CDS 1..687 /locus_tag="YDL199C" /coded_by="NM_001180259.1:1..2064" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /note="Putative transporter; member of the sugar porter family" /db_xref="GeneID:851328" /db_xref="SGD:S000002358" ORIGIN 1 mkpplnmsrs nkpltqeans sahidrahql aqdfnskqdd taltslphkn pdifrfenni 61 tahssrrgsl yrdsdatvvl plsehtprls mddpyrqllq qaeisqlrsk kkrhssrvlr 121 tsfisfvvlv sslsgldqgl isgnvmtlsf qkyfhyplts plgnivsivn lgafmaslfv 181 ysgilepcsr kkmlqistmi yslgaivqvl alnqwclllg rfllgvgmgf afsmviiyqf 241 efplpcirkr tlisiqcvss viaysfgiwi ncafrylgfa wryplsthva lgiilnlmsf 301 ylilespswl lkqkndveal vlisnvfddg nfeenqtqlk frvlkrdill kshlqknsyp 361 yayilkdfss iiklligfql ltrtngvdaf lyysplilqq mgrgerksiy ltglnaliys 421 ivilayvplv lrkrkektnv llgsivmcal lftisftdwf pksttryisi lfavflfthf 481 iswdsigwvm tiellphlsq apvillvsnf ywifkwfvsl itpilidrls wkfylipsls 541 sfisiifvlk ifpietrder ldsdddstgn gsgnhddvfd dtgsefsssp sfsayqintl 601 gssikqnnqa yssiqneqil pkngnlsnqt hgsaqnvyfi tsdsgpsrtg effsfhnrtd 661 pnisdniaan kpssgggqns pgdmava // LOCUS NP_010083 300 aa linear PLN 30-JUN-2025 DEFINITION Ggc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010083 VERSION NP_010083.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180258.1 REFERENCE 1 (residues 1 to 300) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 300) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 300) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 300) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11666. Method: conceptual translation. FEATURES Location/Qualifiers source 1..300 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..300 /product="Ggc1p" /calculated_mol_wt="33084" Region 115..201 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 206..286 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..300 /gene="GGC1" /locus_tag="YDL198C" /gene_synonym="SHM1; YHM1" /coded_by="NM_001180258.1:1..903" /experiment="EXISTENCE:direct assay:GO:0001408 guanine nucleotide transport [PMID:14998997]" /experiment="EXISTENCE:direct assay:GO:0001409 guanine nucleotide transmembrane transporter activity [PMID:14998997]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:14998997]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:14998997]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:14629196]" /note="Mitochondrial GTP/GDP transporter; essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family" /db_xref="GeneID:851329" /db_xref="SGD:S000002357" ORIGIN 1 mphtdkkqsg larllgsasa gimeiavfhp vdtiskrlms nhtkitsgqe lnrvifrdhf 61 seplgkrlft lfpglgyaas ykvlqrvyky ggqpfanefl nkhykkdfdn lfgektgkam 121 rsaaagslig igeivllpld vlkikrqtnp esfkgrgfik ilrdeglfnl yrgwgwtaar 181 napgsfalfg gnafakeyil glkdysqatw sqnfissivg acsslivsap ldviktriqn 241 rnfdnpesgl rivkntlkne gvtaffkglt pkllttgpkl vfsfalaqsl iprfdnllsk // LOCUS NP_010084 525 aa linear PLN 30-JUN-2025 DEFINITION Asf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010084 VERSION NP_010084.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180257.1 REFERENCE 1 (residues 1 to 525) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 525) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 525) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 525) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11667. Method: conceptual translation. FEATURES Location/Qualifiers source 1..525 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..525 /product="Asf2p" /calculated_mol_wt="59216" Region <51..>267 /region_name="235kDa-fam" /note="reticulocyte binding/rhoptry protein; TIGR01612" /db_xref="CDD:130673" CDS 1..525 /gene="ASF2" /locus_tag="YDL197C" /coded_by="NM_001180257.1:1..1578" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:15282802]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:9290207]" /note="Anti-silencing protein; causes derepression of silent loci when overexpressed" /db_xref="GeneID:851330" /db_xref="SGD:S000002356" ORIGIN 1 mpknrgvlda itrsvidgsd qessssfnsd keyaavtkgl sssrvqkkss lrqmkskvke 61 lqslvnhyre neaalvssak llsgeiigye ikmaslhgkm ksildennal kethkssaek 121 rielvrlpss keernydeyt llvnlkkeic aklqdyknvq ntvntkldei htfhekyyeg 181 lelsldskvf daesskelak vrrelnnvrk nseikvnnlk mqllqatksl ehlkkqakak 241 ddylkcipel vdkanltmls ykksianqre tiealqaels qqsetkgqie tetqnqvqip 301 tnvtlvdpfe ennpedlfai qeqelqdlrl hkkmadersr tthlhlerkn ntikllqsyv 361 qsliqrlppa qrkhhlgifq klgsekscpl apavastyap llllsqhsnh qeidntpqrl 421 llaapdgqsy seksttlnld yssrksylsr lqpphianlk sltlktlprv ptdspqlpsk 481 dksqetakkd drpklvanep vtldtstppv aqsladskhc sglhk // LOCUS NP_010086 1273 aa linear PLN 30-JUN-2025 DEFINITION Sec31p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010086 VERSION NP_010086.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180255.2 REFERENCE 1 (residues 1 to 1273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1273) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11668. On Apr 26, 2011 this sequence version replaced NP_010086.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1273 /product="Sec31p" /calculated_mol_wt="138587" Region 12..61 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <14..327 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 66..106 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 111..154 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 164..200 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 212..253 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 260..297 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 303..327 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <772..1172 /region_name="PHA03247" /note="large tegument protein UL36; Provisional" /db_xref="CDD:223021" Region 899..946 /region_name="Sec31" /note="Protein transport protein SEC31; pfam11549" /db_xref="CDD:431930" Region 1133..1265 /region_name="SRA1" /note="Steroid receptor RNA activator (SRA1); pfam07304" /db_xref="CDD:429397" CDS 1..1273 /gene="SEC31" /locus_tag="YDL195W" /gene_synonym="WEB1" /coded_by="NM_001180255.2:1..3822" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:17604721]" /experiment="EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:8004676]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0090114 COPII-coated vesicle budding [PMID:8223424]" /experiment="EXISTENCE:mutant phenotype:GO:0090114 COPII-coated vesicle budding [PMID:12475940]" /note="Component of the Sec13p-Sec31p complex of the COPII vesicle coat; COPII coat is required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance" /db_xref="GeneID:851332" /db_xref="SGD:S000002354" ORIGIN 1 mvklaefsrt atfawshdki pllvsgtvsg tvdanfstds slelwsllaa dsekpiaslq 61 vdskfndldw shnnkiiaga ldngslelys tneannains marfsnhsss vktvkfnakq 121 dnvlasggnn geifiwdmnk ctespsnytp ltpgqsmssv devislawnq slahvfasag 181 ssnfasiwdl kakkevihls ytspnsgikq qlsvvewhpk nstrvatatg sdndpsiliw 241 dlrnantplq tlnqghqkgi lsldwchqde hlllssgrdn tvllwnpesa eqlsqfparg 301 nwcfktkfap eapdlfacas fdnkievqtl qnltntldeq etetkqqese tdfwnnvsre 361 eskekptvfh lqaptwygep spaahwafgg klvqitpdgk gvsitnpkis glesnttlse 421 alktkdfkpl inqrlvkvid dvneedwnll eklsmdgtee flkealafdn desdaqddan 481 nekeddgeef fqqietnfqp egdfslsgni eqtisknlvs gniksavkns lendllmeam 541 vialdsnner lkesvknayf akygskssls rilysiskre vddlvenldv sqwkfiskai 601 qnlypndiaq rnemliklgd rlkenghrqd sltlylaags ldkvasiwls efpdledklk 661 kdnktiyeah secltefier ftvfsnfing sstinneqli akflefinlt tstgnfelat 721 eflnslpsdn eevktekarv liasgkslpa qnpatattsk akytnaktnk nvpvlptpgm 781 psttsipsmq apfygmtpga sanalppkpy vpatttsapv htegkyapps qpsmaspfvn 841 ktnsstrlns fapppnpyat atvpatnvst tsipqntfap iqpgmpimgd ynaqsssips 901 qppinavsgq tphlnrkand gwndlplkvk ekpsrakavs vappnilstp tplngipana 961 astmppppls rapssvsmvs ppplhknsrv pslvatsesp rasisnpyap pqssqqfpig 1021 tistanqtsn taqvassnpy apppqqrvat plsggvppap lpkasnpyap tattqpngss 1081 ypptgpytnn htmtspppvf nkpptgpppi smkkrsnkla sieqnpsqga typptlsssa 1141 splqpsqppt lasqvntsae nvsheipadq qpivdflkee larvtpltpk eyskqlkdcd 1201 krlkilfyhl ekqdlltqpt idclhdlval mkekkykeam vihaniatnh aqeggnwltg 1261 vkrligiaea tln // LOCUS NP_010087 884 aa linear PLN 30-JUN-2025 DEFINITION glucose sensor [Saccharomyces cerevisiae S288C]. ACCESSION NP_010087 VERSION NP_010087.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180254.1 REFERENCE 1 (residues 1 to 884) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 884) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 884) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 884) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11669. Method: conceptual translation. FEATURES Location/Qualifiers source 1..884 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..884 /product="glucose sensor" /calculated_mol_wt="96588" Region 99..556 /region_name="MFS_HXT" /note="Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; cd17356" /db_xref="CDD:340914" Site order(111,115,237,240..241,244,366..367,371..372,375..376, 401,462..463,466..467,471,494..495,498) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..884 /gene="SNF3" /locus_tag="YDL194W" /coded_by="NM_001180254.1:1..2655" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:24124599|PMID:2406560]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0010255 glucose mediated signaling pathway [PMID:9564039]" /experiment="EXISTENCE:mutant phenotype:GO:0015755 fructose transmembrane transport [PMID:2046678]" /experiment="EXISTENCE:mutant phenotype:GO:0015761 mannose transmembrane transport [PMID:2046678]" /experiment="EXISTENCE:mutant phenotype:GO:0045835 negative regulation of meiotic nuclear division [PMID:18616605]" /experiment="EXISTENCE:mutant phenotype:GO:1904659 D-glucose transmembrane transport [PMID:2046678]" /note="Plasma membrane low glucose sensor, regulates glucose transport; high affinity sensor that contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication" /db_xref="GeneID:851333" /db_xref="SGD:S000002353" ORIGIN 1 mdpnsnssse tlrqekqgfl dkalqrvkgi alrrnnsnkd httddttgsi rtptslqrqn 61 sdrqsnmtsv ftddistidd nsilfseppq kqsmmmsicv gvfvavggfl fgydtglins 121 itsmnyvksh vapnhdsfta qqmsilvsfl slgtffgalt apfisdsygr kptiifstif 181 ifsignslqv gaggitlliv grvisgigig aisavvplyq aeathkslrg aiistyqwai 241 twgllvssav sqgtharnda ssyripiglq yvwssflaig mfflpespry yvlkdkldea 301 akslsflrgv pvhdsgllee lveikatydy easfgssnfi dcfissksrp kqtlrmftgi 361 alqafqqfsg infifyygvn ffnktgvsns ylvsfityav nvvfnvpglf fveffgrrkv 421 lvvggvimti anfivaivgc slktvaaakv miaficlfia afsatwggvv wvisaelypl 481 gvrskctaic aaanwlvnfi calitpyivd tgshtsslga kiffiwgsln amgvivvylt 541 vyetkgltle eidelyikss tgvvspkfnk direralkfq ydplqrledg kntfvakrnn 601 fddetprndf rntisgeidh spnqkevhsi pervdiptst eilespnkss gmtvpvspsl 661 qdvpipqtte paeirtkyvd lgnglglnty nrgppslssd ssedytedei ggpssqgdqs 721 nrstmndind ymarlihsts tasnttdkfs gnqstlryht asshsdttee dsnlmdlgng 781 lalnaynrgp psilmnssde eanggetsdn lntaqdlagm kermaqfaqs yidkrgglep 841 etqsnilsts lsvmadtneh nneilhssee natnqpvnen ndlk // LOCUS NP_010088 375 aa linear PLN 30-JUN-2025 DEFINITION ditrans,polycis-polyprenyl diphosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010088 VERSION NP_010088.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180253.1 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11670. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..375 /product="ditrans,polycis-polyprenyl diphosphate synthase" /EC_number="2.5.1.87" /calculated_mol_wt="42426" Region <267..347 /region_name="Cis_IPPS" /note="Cis (Z)-Isoprenyl Diphosphate Synthases; cl00230" /db_xref="CDD:469674" CDS 1..375 /gene="NUS1" /locus_tag="YDL193W" /coded_by="NM_001180253.1:1..1128" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11086160]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093|PMID:24390141|PMID:10515935|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0043048 dolichyl monophosphate biosynthetic process [PMID:25066056]" /experiment="EXISTENCE:direct assay:GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity [PMID:25066056]" /experiment="EXISTENCE:direct assay:GO:1904423 dehydrodolichyl diphosphate synthase complex [PMID:25066056]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:16943325]" /note="Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1; tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY, suggesting that Nus1p may be involved in protein trafficking; mutations in human homolog NUS1 have been implicated in congenital scoliosis, neurological impairment, refractory epilepsy, hearing deficit, and visual impairment; human cis-prenyltransferase complex complements yeast null mutant" /db_xref="GeneID:851334" /db_xref="SGD:S000002352" ORIGIN 1 mptmikkddk ameppnekph rkierddvpe ssnhipppes gvlkggkvns ktralkavts 61 iiadadenpq kkvnnetngv qkqktedlsk rigkfeylfy kfllvllyic fglfrygqyq 121 ynkmklrifs iiynhaytpq lirqdviplk kipkrlaail evkpvgdvgg gvtgllndas 181 eivcwtvsag ikhlmlydyd gilqrnvpel rmeihsnlak yfgpahvpny avkiphsnki 241 fynldgiete tdvgneiean qekdkiaiei sllsnrdgre tivdltktma elcavnelsv 301 sditmdlvds elkqlvgpep dlllyfgpsl dlqgfppwhi rltefywekd nneviysvfi 361 rglrqyagck vnvgk // LOCUS NP_010089 181 aa linear PLN 30-JUN-2025 DEFINITION Arf family GTPase ARF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010089 VERSION NP_010089.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180252.1 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11671. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..181 /product="Arf family GTPase ARF1" /EC_number="3.6.5.2" /calculated_mol_wt="20398" Region 5..179 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site 24..31 /site_type="other" /note="G1 box" /db_xref="CDD:206717" Site order(26..32,126..127,129,159..161) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206717" Site order(26..27,31,35,47..54,76,81) /site_type="other" /note="putative GAP interaction site [polypeptide binding]" /db_xref="CDD:206717" Site 36..51 /site_type="other" /note="Switch I region" /db_xref="CDD:206717" Site order(48..52,57,67,71,73,77,79..81) /site_type="other" /note="GEF interaction site [polypeptide binding]" /db_xref="CDD:206717" Site 48 /site_type="other" /note="G2 box" /db_xref="CDD:206717" Site order(49..51,73,80) /site_type="active" /note="effector interaction site [active]" /db_xref="CDD:206717" Site 51..66 /site_type="active" /note="interswitch region [active]" /db_xref="CDD:206717" Site 67..70 /site_type="other" /note="G3 box" /db_xref="CDD:206717" Site 69..86 /site_type="other" /note="Switch II region" /db_xref="CDD:206717" Site 126..129 /site_type="other" /note="G4 box" /db_xref="CDD:206717" Site 159..161 /site_type="other" /note="G5 box" /db_xref="CDD:206717" CDS 1..181 /gene="ARF1" /locus_tag="YDL192W" /coded_by="NM_001180252.1:1..546" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8816753]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:20841378|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9736713|PMID:9813082]" /experiment="EXISTENCE:direct assay:GO:0044232 organelle membrane contact site [PMID:37400497]" /experiment="EXISTENCE:direct assay:GO:1903292 protein localization to Golgi membrane [PMID:33788598]" /experiment="EXISTENCE:direct assay:GO:1903358 regulation of Golgi organization [PMID:33788598]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]" /experiment="EXISTENCE:genetic interaction:GO:0010636 positive regulation of mitochondrial fusion [PMID:37400497]" /experiment="EXISTENCE:genetic interaction:GO:0019217 regulation of fatty acid metabolic process [PMID:37400497]" /experiment="EXISTENCE:genetic interaction:GO:0090141 positive regulation of mitochondrial fission [PMID:37400497]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20444982]" /experiment="EXISTENCE:physical interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]" /note="ADP-ribosylation factor; GTPase of the Ras superfamily that regulates coated vesicle formation during intracellular trafficking within the Golgi; regulates mitochondrial fission, fusion and function, controlling the flow of fatty acids and metabolites from lipid droplets to peroxisomes and mitochondria; localizes to the Golgi apparatus and the active form to ER and lipid droplets; arf1 arf2 double null mutation is complemented by human ARF1, ARF4, ARF5, or ARF6" /db_xref="GeneID:851335" /db_xref="SGD:S000002351" ORIGIN 1 mglfasklfs nlfgnkemri lmvgldgagk ttvlyklklg evittiptig fnvetvqykn 61 isftvwdvgg qdrirslwrh yyrntegvif vvdsndrsri gearevmqrm lnedelrnaa 121 wlvfankqdl peamsaaeit eklglhsirn rpwfiqatca tsgeglyegl ewlsnslkns 181 t // LOCUS NP_010145 120 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL29 RPL35A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010145 VERSION NP_010145.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180196.2 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11722. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..120 /product="60S ribosomal protein uL29 RPL35A" /calculated_mol_wt="13778" Region 8..60 /region_name="Ribosomal_L29" /note="Ribosomal L29 protein; pfam00831" /db_xref="CDD:459954" CDS 1..120 /gene="RPL35A" /locus_tag="YDL191W" /gene_synonym="SOS1" /coded_by="NM_001180196.2:1..363" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:20392820]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:20392820]" /note="Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication" /db_xref="GeneID:851336" /db_xref="SGD:S000002350" ORIGIN 1 magvkayelr tkskeqlasq lvdlkkelae lkvqklsrps lpkiktvrks iacvltvine 61 qqreavrqly kgkkyqpkdl rakktralrr altkfeasqv tekqrkkqia fpqrkyaika // LOCUS NP_010091 961 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-ubiquitin ligase UFD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010091 VERSION NP_010091.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180250.2 REFERENCE 1 (residues 1 to 961) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 961) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 961) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 961) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 961) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 961) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 961) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 961) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 961) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11673. On Apr 26, 2011 this sequence version replaced NP_010091.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..961 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..961 /product="ubiquitin-ubiquitin ligase UFD2" /EC_number="2.3.2.27" /calculated_mol_wt="109785" Region 1..961 /region_name="UFD2" /note="Ubiquitin fusion degradation protein 2 [Posttranslational modification, protein turnover, chaperones]; COG5113" /db_xref="CDD:227444" CDS 1..961 /gene="UFD2" /locus_tag="YDL190C" /coded_by="NM_001180250.2:1..2886" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15652483|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:10089879]" /experiment="EXISTENCE:direct assay:GO:0034450 ubiquitin-ubiquitin ligase activity [PMID:10089879]" /experiment="EXISTENCE:direct assay:GO:0070936 protein K48-linked ubiquitination [PMID:28165462]" /experiment="EXISTENCE:direct assay:GO:0071361 cellular response to ethanol [PMID:10089879]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10089879|PMID:7615550]" /experiment="EXISTENCE:mutant phenotype:GO:0031398 positive regulation of protein ubiquitination [PMID:27226596]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:21148305]" /note="Conserved ubiquitin (Ub) chain assembly factor (E4); forms branched Ub chains on substrates destined for degradation, catalyzing K48-linked multi-monoubiquitination of K29-linked Ub chains assembled by Ub-ligase Ufd4p; involved in Ub-fusion degradation pathway, OLE membrane fluidity pathway, stress response survival, and ERAD pathway for misfolded proteins where it promotes ubiquitination and transfer of ERAD substrates to Rad23p; U-box family member; homologous to human Ufd2a, Ufd2b" /db_xref="GeneID:851337" /db_xref="SGD:S000002349" ORIGIN 1 mtaiedilqi ttdpsdtrgy sllkseevpq gstlgvdfid tlllyqlten ekldkpfeyl 61 ndcfrrnqqq kritknkpna eslhstfqei drlvigygvv alqienfcmn gafinyitgi 121 vsnvnsytdf lsqiiqrail egtaldllna vfptlleycn khvshfdlne sviynnvlti 181 felfvtfkpi aeiftkidgf fadysckpqd ferktilgpi lslspieaav airnygdnll 241 rskqqtamih eslqaehkvv idrlffivdk lvrgslnsrt dmisyfahia nknhlrradh 301 ppfkelssng fmsnitlllv rfsqpfldis ykkidkidan yfnnpslfid lsgetrlnsd 361 fkeadafydk nrktadskpn fisdcffltl tylhyglggt lsfeekmgse ikalkeeiek 421 vkkiaanhdv farfitaqls kmekalktte slrfalqgff ahrslqlevf dficgastfl 481 irvvdpehef pfkqiklpli pdqigvenvd nadflrahap vpfkyypefv vegpvnysly 541 iskyqtspif rnprlgsfve fttmvlrcpe lvsnphlkgk lvqllsvgam pltdnspgfm 601 mdifehdelv nknllyalld fyvivektgs ssqfydkfns rysisiilee lyykipsykn 661 qliwqsqnna dffvrfvarm lndltfllde glsnlaevhn iqneldnrar gapptreeed 721 kelqtrlasa srqaksscgl adksmklfei yskdipaafv tpeivyrlas mlnynleslv 781 gpkcgelkvk dpqsysfnpk dllkalttvy inlseqsefi savakdersf nrnlfvravd 841 ilgrktglas pefiekllnf ankaeeqrka deeedleygd vpdefldplm ytimkdpvil 901 paskmnidrs tikahllsds tdpfnrmplk ledvtpneel rqkilcfkkq kkeeakhkas 961 e // LOCUS NP_010092 457 aa linear PLN 30-JUN-2025 DEFINITION Rbs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010092 VERSION NP_010092.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180249.1 REFERENCE 1 (residues 1 to 457) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 457) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 457) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 457) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11674. On Aug 9, 2000 this sequence version replaced NP_010092.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..457 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..457 /product="Rbs1p" /calculated_mol_wt="51826" Region 25..85 /region_name="R3H_encore_like" /note="R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H...; cd02642" /db_xref="CDD:100071" Site order(57,61) /site_type="other" /note="RxxxH motif" /db_xref="CDD:100071" CDS 1..457 /gene="RBS1" /locus_tag="YDL189W" /coded_by="NM_001180249.1:1..1374" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25605335]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0048027 mRNA 5'-UTR binding [PMID:34688816]" /experiment="EXISTENCE:genetic interaction:GO:0006012 galactose metabolic process [PMID:12372297]" /experiment="EXISTENCE:mutant phenotype:GO:1990115 RNA polymerase III assembly [PMID:25605335]" /note="Protein involved in assembly of the RNA Pol III complex; high copy suppressor of Pol III assembly mutation and psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; physically interacts with Pol III; proposed to bind single-stranded nucleic acids via its R3H domain; capable of forming the prion [VTS1+]" /db_xref="GeneID:851338" /db_xref="SGD:S000002348" ORIGIN 1 mtaldsrnwg ltpametglf qkpqdrifii elensivsfi nsntesfqlr pmnsyyrlls 61 hqiaeyhnln hvlartqdsc vilfkgenfq kiegkpllqe lqlnkkpeec asssesieks 121 nnnrifrilk rkevgnecdy kidgntrtpn snltansnkd qkieiddkss tdleqeriek 181 erlyeqrkqe ifdklnksed dvkstnssgs sdsdnewsdw lngddsntqt sngsvssssp 241 fnssvttiqv nkpqqqfyds rrgrggrrrg tnnykdayrg qsrrnkengg yqsgysspyl 301 vypppqmggn slptyplmyn pagpapgpap spmvmgnntv fmnpymynmn pqgscsfgtp 361 ipmyppyqyq yqyqyntqyh sgpysntpsy nsnnytrssa nkyhhfqgkn sysgaipkrs 421 ddsnsnkneg irrasvegsp ssrdtdsvem kfdklni // LOCUS NP_010093 377 aa linear PLN 30-JUN-2025 DEFINITION phosphoprotein phosphatase 2A catalytic subunit PPH22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010093 VERSION NP_010093.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180248.1 REFERENCE 1 (residues 1 to 377) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 377) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 377) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 377) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11675. Method: conceptual translation. FEATURES Location/Qualifiers source 1..377 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..377 /product="phosphoprotein phosphatase 2A catalytic subunit PPH22" /EC_number="3.1.3.16" /calculated_mol_wt="42916" Region 78..360 /region_name="MPP_PP2A_PP4_PP6" /note="PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain; cd07415" /db_xref="CDD:277360" Site order(119,135,138..139,141..142,144,146..147,159,174..178, 189..190,193..194,198..199,202..203,211,336,345,355) /site_type="other" /note="heterotrimer interface [polypeptide binding]" /db_xref="CDD:277360" Site order(125,127,153,157,185..186,190..191,195,235,257..259, 268,281..283,309,311,335..337) /site_type="active" /db_xref="CDD:277360" Site order(125,127,153,185,235,309) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277360" CDS 1..377 /gene="PPH22" /locus_tag="YDL188C" /gene_synonym="PPH2" /coded_by="NM_001180248.1:1..1134" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:16541024]" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:12135475|PMID:25387524]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12518319]" /experiment="EXISTENCE:genetic interaction:GO:1903432 regulation of TORC1 signaling [PMID:12820961]" /experiment="EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:27973551]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:25387524]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:25387524]" /experiment="EXISTENCE:mutant phenotype:GO:2000198 negative regulation of ribonucleoprotein complex localization [PMID:25387524]" /experiment="EXISTENCE:physical interaction:GO:0006417 regulation of translation [PMID:10329624]" /note="Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph21p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; dephosphorylates Tel1p/Mec1p-phosphorylated Cdc13p to promote telomerase release from telomeres at G2/M; PPH22 has a paralog, PPH21, that arose from the whole genome duplication" /db_xref="GeneID:851339" /db_xref="SGD:S000002347" ORIGIN 1 mdmeiddpmh gsdedqlspt ldedmnsddg knntkarsnd edtdeeledf nfkpgssgia 61 dhksskplkl tntninqldq wiehlskcep lseddvarlc kmavdvlqfe envkpinvpv 121 ticgdvhgqf hdllelfkig gpcpdtnylf mgdyvdrgyy svetvsylva mkvryphrit 181 ilrgnhesrq itqvygfyde clrkygsanv wkmftdlfdy fpvtalvdnk ifclhgglsp 241 mietidqvrd lnriqevphe gpmcdllwsd pddrggwgis prgagftfgq diseqfnhtn 301 dlsliarahq lvmegyswsh qqnvvtifsa pnycyrcgnq aaimevdenh nrqflqydps 361 vrpgeptvtr ktpdyfl // LOCUS NP_010095 277 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL186W [Saccharomyces cerevisiae S288C]. ACCESSION NP_010095 VERSION NP_010095.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180246.1 REFERENCE 1 (residues 1 to 277) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 277) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 277) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 277) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11676. Method: conceptual translation. FEATURES Location/Qualifiers source 1..277 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..277 /product="uncharacterized protein" /calculated_mol_wt="32066" CDS 1..277 /locus_tag="YDL186W" /coded_by="NM_001180246.1:1..834" /note="hypothetical protein; YDL186W is not an essential gene" /db_xref="GeneID:851340" /db_xref="SGD:S000002345" ORIGIN 1 mqcntsiedg ldggditfps yspeaeaqnr flprsefpsv rqlviskqks rrrreenvfv 61 gkmedvlvkw rppasshrga ieaingthpy qlstaqfnsr rsdpfgstkr desvrsives 121 ftdwwkrnsk mffrdeeegv rtehsasqdd qelqlfeedl fsfhlspndm strnsehqvq 181 tpvlfpyeap trtkqnpaer kvieigdgee lsiyrdvysn pipvsyldtl nlnhsmsvrq 241 tqqqqqqrqq qqyvdsssaf qcctdsnwar iffchhd // LOCUS NP_010096 1071 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V1 sector ATPase subunit A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010096 VERSION NP_010096.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180245.1 REFERENCE 1 (residues 1 to 1071) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1071) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1071) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1071) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11677. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1071 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1071 /product="H(+)-transporting V1 sector ATPase subunit A" /EC_number="7.1.2.2" /calculated_mol_wt="118506" Region 26..>284 /region_name="PRK04192" /note="V-type ATP synthase subunit A; Provisional" /db_xref="CDD:235248" Region 284..736 /region_name="Hom_end_hint" /note="Hom_end-associated Hint; pfam05203" /db_xref="CDD:368334" Region <733..1063 /region_name="V-ATPase_V1_A" /note="V-type (H+)-ATPase V1, A subunit; TIGR01042" /db_xref="CDD:273411" CDS 1..1071 /gene="VMA1" /locus_tag="YDL185W" /gene_synonym="CLS8; TFP1" /coded_by="NM_001180245.1:1..3216" /experiment="EXISTENCE:direct assay:GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain [PMID:8626613|PMID:2478556|PMID:1530931]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:7775427|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0019538 protein metabolic process [PMID:8508780]" /experiment="EXISTENCE:direct assay:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:8718887]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:29519938|PMID:18048916]" /note="Subunit A of the V1 peripheral membrane domain of V-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner" /db_xref="GeneID:851342" /db_xref="SGD:S000002344" ORIGIN 1 magaienark eikrisledh aeseygaiys vsgpvviaen migcamyelv kvghdnlvge 61 viridgdkat iqvyeetagl tvgdpvlrtg kplsvelgpg lmetiydgiq rplkaikees 121 qsiyiprgid tpaldrtikw qftpgkfqvg dhisggdiyg svfensliss hkillpprsr 181 gtitwiapag eytldekile vefdgkksdf tlyhtwpvrv prpvteklsa dyplltgqrv 241 ldalfpcvqg gttcipgafg cgktvisqsl skysnsdaii yvgcfakgtn vlmadgsiec 301 ienievgnkv mgkdgrprev iklprgretm ysvvqksqhr ahksdssrev pellkftcna 361 thelvvrtpr svrrlsrtik gveyfevitf emgqkkapdg rivelvkevs ksypisegpe 421 ranelvesyr kasnkayfew tieardlsll gshvrkatyq tyapilyend hffdymqksk 481 fhltiegpkv layllglwig dglsdratfs vdsrdtslme rvteyaekln lcaeykdrke 541 pqvaktvnly skvvrgngir nnlntenplw daivglgflk dgvknipsfl stdnigtret 601 flaglidsdg yvtdehgika tiktihtsvr dglvslarsl glvvsvnaep akvdmngtkh 661 kisyaiymsg gdvllnvlsk cagskkfrpa paaafarecr gfyfelqelk eddyygitls 721 ddsdhqflla nqvvvhncge rgnemaevlm efpelytems gtkepimkrt tlvantsnmp 781 vaareasiyt gitlaeyfrd qgknvsmiad sssrwaealr eisgrlgemp adqgfpaylg 841 aklasfyera gkavalgspd rtgsvsivaa vspaggdfsd pvttatlgit qvfwgldkkl 901 aqrkhfpsin tsvsyskytn vlnkfydsny pefpvlrdrm keilsnaeel eqvvqlvgks 961 alsdsdkitl dvatlikedf lqqngystyd afcpiwktfd mmrafisyhd eaqkavanga 1021 nwskladstg dvkhavsssk ffepsrgeke vhgefeklls tmqerfaest d // LOCUS NP_010097 25 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL41 RPL41A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010097 VERSION NP_010097.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180244.1 REFERENCE 1 (residues 1 to 25) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 25) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 25) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 25) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11678. Method: conceptual translation. FEATURES Location/Qualifiers source 1..25 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..25 /product="60S ribosomal protein eL41 RPL41A" /calculated_mol_wt="3206" CDS 1..25 /gene="RPL41A" /locus_tag="YDL184C" /gene_synonym="RPL47A" /coded_by="NM_001180244.1:1..78" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L41A; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41A has a paralog, RPL41B, that arose from the whole genome duplication" /db_xref="GeneID:851344" /db_xref="SGD:S000002343" ORIGIN 1 mrakwrkkrt rrlkrkrrkv rarsk // LOCUS NP_010098 320 aa linear PLN 30-JUN-2025 DEFINITION Mrx19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010098 VERSION NP_010098.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180243.1 REFERENCE 1 (residues 1 to 320) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 320) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 320) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 320) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11679. Method: conceptual translation. FEATURES Location/Qualifiers source 1..320 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..320 /product="Mrx19p" /calculated_mol_wt="36916" Region 46..241 /region_name="Mit_KHE1" /note="Mitochondrial K+-H+ exchange-related; pfam10173" /db_xref="CDD:431110" CDS 1..320 /gene="MRX19" /locus_tag="YDL183C" /coded_by="NM_001180243.1:1..963" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:20197279]" /experiment="EXISTENCE:genetic interaction:GO:0006813 potassium ion transport [PMID:20197279]" /experiment="EXISTENCE:genetic interaction:GO:1902600 proton transmembrane transport [PMID:20197279]" /note="Protein that may form an active mitochondrial KHE system; mitochondrial inner-membrane protein; non-essential gene; KHE system stands for K+/H+ exchanger system" /db_xref="GeneID:851345" /db_xref="SGD:S000002342" ORIGIN 1 mirsifippt sitatsrlfy gmraystkle kaslqkylhd pvkvtvipit dkesfiyykh 61 tdnlfnsqsr ilkaekwive ksaklwrklk kspksynkki vsmvqsllns tpwsensllt 121 ipsesyilkr ikgekdktqe irltlkdytv kaeqvdtqpl hvyyppgiss pdeclrqmkk 181 lyqegliyhk kwtlycllgl pltiplilip lipnvpgfyl syrayvnika ylgakhlksl 241 lesskqnlef rellgytevy krgtssrtqg nqkeskgape lllnkktlpl ildflevhel 301 esdlnkvilq esksqeknki // LOCUS NP_010099 428 aa linear PLN 30-JUN-2025 DEFINITION homocitrate synthase LYS20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010099 VERSION NP_010099.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180242.1 REFERENCE 1 (residues 1 to 428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 428) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11680. Method: conceptual translation. FEATURES Location/Qualifiers source 1..428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..428 /product="homocitrate synthase LYS20" /EC_number="2.3.3.14" /calculated_mol_wt="46968" Region 23..284 /region_name="DRE_TIM_HCS" /note="Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; cd07948" /db_xref="CDD:163685" Site order(31..32,35,62,91,93,155,183,212,214) /site_type="active" /db_xref="CDD:163685" Site order(31..32,62) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:163685" Site order(32,183,212,214) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:163685" CDS 1..428 /gene="LYS20" /locus_tag="YDL182W" /coded_by="NM_001180242.1:1..1287" /experiment="EXISTENCE:direct assay:GO:0004410 homocitrate synthase activity [PMID:14984204]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9099739|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:25628362]" /experiment="EXISTENCE:genetic interaction:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:18524920]" /experiment="EXISTENCE:mutant phenotype:GO:0004410 homocitrate synthase activity [PMID:8923736]" /note="Homocitrate synthase isozyme and functions in DNA repair; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication" /db_xref="GeneID:851346" /db_xref="SGD:S000002341" ORIGIN 1 mtaakpnpya akpgdylsnv nnfqlidstl regeqfanaf fdtekkieia ralddfgvdy 61 ieltspvase qsrkdceaic klglkakilt hirchmddak vavetgvdgv dvvigtskfl 121 rqyshgkdmn yiaksavevi efvkskgiei rfssedsfrs dlvdllniyk tvdkigvnrv 181 giadtvgcan prqvyelirt lksvvscdie chfhndtgca ianaytaleg garlidvsvl 241 gigerngitp lgglmarmiv aapdyvksky klhkirdien lvadavevni pfnnpitgfc 301 afthkagiha kailanpsty eildphdfgm kryihfanrl tgwnaikarv dqlnlnltdd 361 qikevtakik klgdvrslni ddvdsiiknf haevstpqvl sakknkknds dvpelatipa 421 akrtkpsa // LOCUS NP_010100 85 aa linear PLN 30-JUN-2025 DEFINITION ATPase inhibitor [Saccharomyces cerevisiae S288C]. ACCESSION NP_010100 VERSION NP_010100.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180241.1 REFERENCE 1 (residues 1 to 85) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 85) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 85) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 85) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11681. Method: conceptual translation. FEATURES Location/Qualifiers source 1..85 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..85 /product="ATPase inhibitor" /calculated_mol_wt="9739" Region 4..85 /region_name="IATP" /note="Mitochondrial ATPase inhibitor, IATP; pfam04568" /db_xref="CDD:428014" CDS 1..85 /gene="INH1" /locus_tag="YDL181W" /coded_by="NM_001180241.1:1..258" /experiment="EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:12167646]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:12809520|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0032780 negative regulation of ATP-dependent activity [PMID:12809520]" /experiment="EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:15294286]" /note="Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has a calmodulin-binding motif and binds calmodulin in vitro; INH1 has a paralog, STF1, that arose from the whole genome duplication" /db_xref="GeneID:851347" /db_xref="SGD:S000002340" ORIGIN 1 mlprsalars lqlqrgvaar fysegstgtp rgsgsedsfv kreratedff vrqrekeqlr 61 hlkeqlekqr kkidslenki dsmtk // LOCUS NP_010101 547 aa linear PLN 30-JUN-2025 DEFINITION Ait1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010101 VERSION NP_010101.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180240.1 REFERENCE 1 (residues 1 to 547) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 547) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 547) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 547) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11682. Method: conceptual translation. FEATURES Location/Qualifiers source 1..547 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..547 /product="Ait1p" /calculated_mol_wt="62157" CDS 1..547 /gene="AIT1" /locus_tag="YDL180W" /coded_by="NM_001180240.1:1..1644" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:36047762|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0034198 cellular response to amino acid starvation [PMID:36047762]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:36047762]" /note="G protein-coupled receptor-like protein; involved in negatively regulating TORC1 activity; green fluorescent protein (GFP)-fusion protein localizes to the vacuole" /db_xref="GeneID:851374" /db_xref="SGD:S000002339" ORIGIN 1 mvrlnhaasy fmpifcstrp hivilsalfs islfslfyas selllhqydd plmfkpnsqd 61 yfrtfllglf spflyyflkt flfninqrfl ilnlivdfpi ndvfmllili glaypqvqdh 121 eggtikhkec swhiiprqay ifgiswalge fticiignlf nyqeiadpni nsgfthqesa 181 ntycnnndms hnddcgcste yrpnvvdrsd itlskcievr ndsssisnnv ysseyhpikp 241 lrsssstygs irqqphenkk qlhvpdnsqd dtiimmnpid nslklttldt gdlsfpidee 301 qpilkksfgy twavpnentq nttksftpik rfiafstayq lvtglllmil vvgsnimlti 361 geslilsmyf vyvrgheglf tpvvnyfgsr tisnfilcvi ipfislnfli ntsiylrrel 421 ddwfnnsqge fedddentis krvatnqeyq hplsanyism dspdvinssp ghfgmnsgql 481 lgnttlyygs lngddddmtn dsallrfckk lvknwralar ndsfvlgvmv swsllvfvtg 541 ilstvyi // LOCUS NP_010102 304 aa linear PLN 30-JUN-2025 DEFINITION Pcl9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010102 VERSION NP_010102.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180239.1 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11683. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..304 /product="Pcl9p" /calculated_mol_wt="34667" Region 48..143 /region_name="CYCLIN_ScPCL1-like" /note="cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; cd20557" /db_xref="CDD:410260" Site order(65,105,113..115,131,134..135) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410260" CDS 1..304 /gene="PCL9" /locus_tag="YDL179W" /coded_by="NM_001180239.1:1..915" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:17853895]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17853895]" /experiment="EXISTENCE:genetic interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]" /experiment="EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:9593297]" /experiment="EXISTENCE:physical interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:9593297]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /experiment="EXISTENCE:physical interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]" /note="Cyclin; forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p; PCL9 has a paralog, PCL2, that arose from the whole genome duplication" /db_xref="GeneID:851375" /db_xref="SGD:S000002338" ORIGIN 1 misdydallq fnkkpvsqem iqflatstas iikirennnp iqgcrppdls ifiknvviqs 61 nvqtptlmat svylnklksv ipknvygint trhriflgcl ilaaktlnds spwnkhwtty 121 tegllrirev ntierelley lnwdvrittp dlidslsyfl gpikeqlflq rrqemllfna 181 pspgqlkeyi nhrrpvshsr tssaisvpsl tsmatvsttd srssllakyq pslplvesdn 241 fnkknhvplr nnndicnnfr aeenihsvnh idvtmgsspv mshkptihqr lnftrrgwss 301 ffkq // LOCUS NP_010103 530 aa linear PLN 30-JUN-2025 DEFINITION D-lactate dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010103 VERSION NP_010103.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180238.1 REFERENCE 1 (residues 1 to 530) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 530) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 530) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 530) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11684. Method: conceptual translation. FEATURES Location/Qualifiers source 1..530 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..530 /product="D-lactate dehydrogenase" /EC_number="1.1.2.4" /EC_number="1.1.99.40" /calculated_mol_wt="59138" Region 61..528 /region_name="GlcD" /note="FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion]; COG0277" /db_xref="CDD:440046" CDS 1..530 /gene="DLD2" /locus_tag="YDL178W" /gene_synonym="AIP2" /coded_by="NM_001180238.1:1..1593" /experiment="EXISTENCE:direct assay:GO:0004458 D-lactate dehydrogenase (cytochrome) activity [PMID:10509019]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10509019]" /experiment="EXISTENCE:direct assay:GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity [PMID:26774271]" /experiment="EXISTENCE:direct assay:GO:0071949 FAD binding [PMID:26774271]" /experiment="EXISTENCE:mutant phenotype:GO:0003779 actin binding [PMID:15158445]" /experiment="EXISTENCE:mutant phenotype:GO:1903457 lactate catabolic process [PMID:26774271]" /note="D-2-hydroxyglutarate dehydrogenase, and minor D-lactate dehydrogenase; mitochondrial matrix protein that oxidizes D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate with a minor role in lactate catabolism; located in the mitochondrial matrix" /db_xref="GeneID:851376" /db_xref="SGD:S000002337" ORIGIN 1 mlrnilvrst gsnfkfagry mkssallgyy rrvnyystki qtrltsenyp dvhrdprfkk 61 ltsddlnyfk silseqeilr asesedlsfy nedwmrkykg qsklvlrpks vekvslilny 121 cndekiavvp qggntglvgg svpifdelil slanlnkird fdpvsgilkc dagvilenan 181 nyvmeqnymf pldlgakgsc hvggvvatna gglrllrygs lhgsvlglev vmpngqivns 241 mhsmrkdntg ydlkqlfigs egtigiitgv siltvpkpka fnvsylsves fedvqkvfvr 301 arqelseils afefmdaksq vlaksqlkda afpledehpf yilietsgsn kdhddsklet 361 flenvmeegi vtdgvvaqde telqnlwkwr emipeasqan ggvykydvsl plkdlyslve 421 atnarlseae lvgdspkpvv gaigyghvgd gnlhlnvavr eynkniektl epfvyefvss 481 khgsvsaehg lgfqkknyig yskspeevkm mkdlkvhydp ngilnpykyi // LOCUS NP_010104 170 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL177C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010104 VERSION NP_010104.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180237.1 REFERENCE 1 (residues 1 to 170) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 170) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 170) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 170) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11685. Method: conceptual translation. FEATURES Location/Qualifiers source 1..170 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..170 /product="uncharacterized protein" /calculated_mol_wt="18927" Region 21..163 /region_name="UPF0029" /note="Uncharacterized protein family UPF0029; pfam01205" /db_xref="CDD:460111" CDS 1..170 /locus_tag="YDL177C" /coded_by="NM_001180237.1:1..513" /note="hypothetical protein; similar to the mouse IMPACT gene; YDL177C is not an essential gene" /db_xref="GeneID:851377" /db_xref="SGD:S000002336" ORIGIN 1 msknvgklvk iwnesevlvd rkskfqarcc plqnqkdips ilqeltqnnk svskashmhm 61 yawrtaevsn nlhlqqeqkk kgnkanksnn shvnksrnit vqpknieqgc adcgeagagq 121 rlltlleran ifnvlvivtr wyggtplgss rfrhistcav etlkkggflp // LOCUS NP_010105 708 aa linear PLN 30-JUN-2025 DEFINITION Gid12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010105 VERSION NP_010105.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180236.1 REFERENCE 1 (residues 1 to 708) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 708) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 708) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 708) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11686. Method: conceptual translation. FEATURES Location/Qualifiers source 1..708 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..708 /product="Gid12p" /calculated_mol_wt="81334" CDS 1..708 /gene="GID12" /locus_tag="YDL176W" /gene_synonym="IPF1" /coded_by="NM_001180236.1:1..2127" /experiment="EXISTENCE:direct assay:GO:0043254 regulation of protein-containing complex assembly [PMID:35650207]" /experiment="EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:32064787]" /note="hypothetical protein involved in regulating assembly of Gid4p into the GID E3 ligase complex; interacts with GID complex components; involved in actin patch formation; computationally predicted to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; non-essential gene" /db_xref="GeneID:851378" /db_xref="SGD:S000002335" ORIGIN 1 matgriqfav stpcntkgkp sgyrlfefkn drlalvpser gctkvdvnan iqafcylrpn 61 grdtsispda thildscdym vlaksngfie iisnyqykik nglrlapsyi lrctpedfes 121 nffsdymiag leysqgllyc cmcsgriyvf vmnlptdyiq yknmynpmfp dcffkvhhdn 181 ntthsseeek lfegstrytg rscskhicyf llpiepshlr sspvvssfcn myqglpiyrp 241 smylhiergi stfhinpldr fcfmtvsprs plfirkiilp ltyvtflstf islknsiqgd 301 tcgeilswdn vaqqngfgsl fswisnkftf dtdiinstiw ddivkysgtg mldsgivwkq 361 rqghakddiy elfhtqdmlg ssrrnssfst asseprplsr rrresfqalt rdafrermdv 421 pcstkwelds firglrrntf mvdfeiveki shrngndgvn eddnttdesd etmtsfltdn 481 ykkmdivcid hfvtlsafrp ryydepiiki dslsnkngse ngtneeewae sqmkvdgqvi 541 ddetaqfkqa lgnlcsfkkl fmlddslcfi ldthgvllin rfeikntknl lrnskdtiri 601 iphdfglind tiviindidv gtdnvcaltf hlvvtsmage itvlkgeffk ncrlgriklc 661 dslklnrkdr fvdklalidy dglnaqkrrl dydekdlytf ivkkvkrd // LOCUS NP_010106 344 aa linear PLN 30-JUN-2025 DEFINITION TRAMP complex RNA-binding subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_010106 VERSION NP_010106.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180235.1 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11687. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..344 /product="TRAMP complex RNA-binding subunit" /calculated_mol_wt="39213" Region 1..209 /region_name="AIR1" /note="Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; COG5082" /db_xref="CDD:227414" CDS 1..344 /gene="AIR2" /locus_tag="YDL175C" /coded_by="NM_001180235.1:1..1035" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:22402490]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16541108]" /experiment="EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:15935759|PMID:15828860|PMID:15935758]" /experiment="EXISTENCE:direct assay:GO:0034458 3'-5' RNA helicase activity [PMID:22532666]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15935758|PMID:15828860|PMID:17643380]" /experiment="EXISTENCE:direct assay:GO:1990817 poly(A) RNA polymerase activity [PMID:15935759|PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing [PMID:17410208]" /experiment="EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:18007593|PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process [PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]" /experiment="EXISTENCE:genetic interaction:GO:1990817 poly(A) RNA polymerase activity [PMID:15935759]" /experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:22319136]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:22402490]" /note="RNA-binding subunit of the TRAMP nuclear RNA surveillance complex; involved in nuclear RNA processing and degradation; involved in TRAMP complex assembly as a bridge between Mtr4p and Trf4p; stimulates the poly(A) polymerase activity of Pap2p in vitro; has 5 zinc knuckle motifs; AIR2 has a paralog, AIR1, that arose from the whole genome duplication; Air2p and Air1p have nonredundant roles in regulation of substrate specificity of the exosome" /db_xref="GeneID:851379" /db_xref="SGD:S000002334" ORIGIN 1 mekntapfvv dtapttppdk lvapsieevn snpnelralr gqgryfgvsd ddkdaikeaa 61 pkcnncsqrg hlkkdcphii csycgatddh ysrhcpkaiq cskcdevghy rsqcphkwkk 121 vqctlckskk hskercpsiw rayilvddne kakpkvlpfh tiycyncggk ghfgddckek 181 rssrvpnedg saftgsnlsv elkqeyyrhm nrnsdenedy qfsesiyded plprpshkrh 241 sqndhshsgr nkrrasnfhp ppyqksnviq ptirgetlsl nnnisknsry qntkvnvssi 301 senmygsryn pstyvdnnsi snssnyrnyn syqpyrsgtl gkrr // LOCUS NP_010107 587 aa linear PLN 30-JUN-2025 DEFINITION D-lactate dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010107 VERSION NP_010107.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180234.1 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11688. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..587 /product="D-lactate dehydrogenase" /EC_number="1.1.2.4" /calculated_mol_wt="65162" Region 110..578 /region_name="GlcD" /note="FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion]; COG0277" /db_xref="CDD:440046" CDS 1..587 /gene="DLD1" /locus_tag="YDL174C" /coded_by="NM_001180234.1:1..1764" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:11502169|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9525904]" /experiment="EXISTENCE:mutant phenotype:GO:0004458 D-lactate dehydrogenase (cytochrome) activity [PMID:8492799]" /experiment="EXISTENCE:mutant phenotype:GO:1903457 lactate catabolic process [PMID:26774271|PMID:8492799]" /note="Major mitochondrial D-lactate dehydrogenase; oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane" /db_xref="GeneID:851380" /db_xref="SGD:S000002333" ORIGIN 1 mlwkrtctrl ikpiaqprgr lvrrscyrya stgtgstdss sqwlkysvia ssatlfgylf 61 aknlysretk edlieklemv kkidpvnstl klssldspdy lhdpvkidkv vedlkqvlgn 121 kpenysdaks dldahsdtyf nthhpspeqr priilfphtt eevskilkic hdnnmpvvpf 181 sggtsleghf lptrigdtit vdlskfmnnv vkfdkldldi tvqaglpwed lndylsdhgl 241 mfgcdpgpga qiggciansc sgtnayrygt mkeniinmti vlpdgtivkt kkrprkssag 301 ynlnglfvgs egtlgivtea tvkchvkpka etvavvsfdt ikdaaacasn ltqsgihlna 361 melldenmmk linasestdr cdwvekptmf fkiggrspni vnalvdevka vaqlnhcnsf 421 qfakdddekl elwearkval wsvldadksk dksakiwttd vavpvsqfdk vihetkkdmq 481 asklinaivg hagdgnfhaf ivyrtpeehe tcsqlvdrmv kralnaegtc tgehgvgigk 541 reylleelge apvdlmrkik laidpkrimn pdkifktdpn epandyr // LOCUS NP_010108 295 aa linear PLN 30-JUN-2025 DEFINITION Par32p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010108 VERSION NP_010108.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180233.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11689. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..295 /product="Par32p" /calculated_mol_wt="31755" Region <20..77 /region_name="DUF3602" /note="Protein of unknown function (DUF3602); pfam12223" /db_xref="CDD:432408" CDS 1..295 /gene="PAR32" /locus_tag="YDL173W" /gene_synonym="AMU1" /coded_by="NM_001180233.1:1..888" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:26172854]" /note="Low complexity protein; mediates inhibition of Mep1p and Mep3p activity; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylation and localization regulated by TORC1-effector kinase, Npr1p" /db_xref="GeneID:851381" /db_xref="SGD:S000002332" ORIGIN 1 matfnpqnem enqarvqeyk vstgrggagn ihksmskpsp vllplksnsk tvannnnngs 61 nqekvprfai grggagnifh dphltrsaqq ldsndninyn dvindiddyi spitsdmvde 121 ggsnpvtntr srisatrshq slhattsspn nnapivvgrg gagniffnkk kvasnggnee 181 deirggnied edtinanedn lfvvtsngna laaikstskk pknklkgksa pekfaigrgg 241 agniispkss rntinhnlnd ddedkfnlkd dngkekkkkk kkksgffssl ktmfn // LOCUS NP_010110 2145 aa linear PLN 30-JUN-2025 DEFINITION glutamate synthase (NADH) [Saccharomyces cerevisiae S288C]. ACCESSION NP_010110 VERSION NP_010110.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180231.1 REFERENCE 1 (residues 1 to 2145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2145) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 2145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 2145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 2145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11690. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..2145 /product="glutamate synthase (NADH)" /EC_number="1.4.1.14" /calculated_mol_wt="237972" Region 41..1547 /region_name="gltB" /note="glutamate synthase subunit alpha; Provisional; PRK11750" /db_xref="CDD:236968" Region 1640..2125 /region_name="GOGAT_sm_gam" /note="glutamate synthases, NADH/NADPH, small subunit; TIGR01317" /db_xref="CDD:162300" CDS 1..2145 /gene="GLT1" /locus_tag="YDL171C" /coded_by="NM_001180231.1:1..6438" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0016040 glutamate synthase (NADH) activity [PMID:7836314]" /experiment="EXISTENCE:expression pattern:GO:0006537 glutamate biosynthetic process [PMID:9657994]" /experiment="EXISTENCE:expression pattern:GO:0019676 ammonia assimilation cycle [PMID:11356843]" /experiment="EXISTENCE:mutant phenotype:GO:0016040 glutamate synthase (NADH) activity [PMID:7836314]" /note="NAD(+)-dependent glutamate synthase (GOGAT); synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source; assembles into filaments as cells approach stationary phase and under cytosolic acidification and starvation conditions" /db_xref="GeneID:851383" /db_xref="SGD:S000002330" ORIGIN 1 mpvlksdnfd pleeayeggt iqnyndehhl hkswanvipd krglydpdye hdacgvgfva 61 nkhgeqshki vtdaryllvn mthrgavssd gngdgagill giphefmkre fkldldldip 121 emgkyavgnv ffkkneknnk knlikcqkif edlaasfnls vlgwrnvpvd stilgdvals 181 reptilqpll vplydekqpe fnetkfrtql yllrkeaslq iglenwfyvc slnnttivyk 241 gqltpaqvyn yypdltnahf kshmalvhsr fstntfpswd raqplrwlah ngeintlrgn 301 knwmrsregv mnsatfkdel dklypiieeg gsdsaaldnv lelltingtl slpeavmmmv 361 peayhkdmds dlkawydwaa clmepwdgpa lltftdgryc gaildrnglr pcryyitsdd 421 rvicasevgv ipienslvvq kgklkpgdlf lvdtqlgemv dtkklksqis krqdfkswls 481 kviklddlls ktanlvpkef isqdslslkv qsdprllang ytfeqvtfll tpmaltgkea 541 lgsmgndapl aclnenpvll ydyfrqlfaq vtnppidpir eanvmslecy vgpqgnllem 601 hssqcdrlll kspilhwnef qalknieaay pswsvaeidi tfdksegllg ytdtidkitk 661 laseaiddgk kiliitdrkm ganrvsissl iaiscihhhl irnkqrsqva liletgeare 721 ihhfcvllgy gcdgvypyla metlvrmnre gllrnvnndn dtleegqile nykhaidagi 781 lkvmskmgis tlasykgaqi fealgldnsi vdlcftgtss rirgvtfeyl aqdafslher 841 gypsrqtisk svnlpesgey hfrdggykhv neptaiaslq dtvrnkndvs wqlyvkkeme 901 airdctlrgl leldfensvs ipleqvepwt eiarrfasga msygsismea hstlaiamnr 961 lgaksncgeg gedaersavq engdtmrsai kqvasarfgv tsyylsdade iqikiaqgak 1021 pgeggelpah kvskdiaktr hstpnvglis ppphhdiysi edlkqliydl kcanpragis 1081 vklvsevgvg ivasgvakak adhilvsghd ggtgaarwts vkyaglpwel glaethqtlv 1141 lndlrrnvvv qtdgqlrtgf diavavllga esftlatvpl iamgcvmlrr chlnscavgi 1201 atqdpylrsk fkgqpehvin ffyyliqdlr qimaklgfrt idemvghsek lkkrddvnak 1261 ainidlspil tpahvirpgv ptkftkkqdh klhtrldnkl ideaevtldr glpvnidasi 1321 intdralgst lsyrvskkfg edglpkdtvv vniegsagqs fgaflasgit filngdandy 1381 vgkglsggii vikppkdskf ksdenvivgn tcfygatsgt afisgsager fgvrnsgati 1441 vverikgnna feymtggrai vlsqmeslna fsgatggiay cltsdyddfv gkinkdtvel 1501 eslcdpveia fvknliqehw nytqsdlaar ilgnfnhylk dfvkviptdy kkvllkekae 1561 aakakakats eylkkfrsnq evddevntll ianqkakeqe kkksitisnk atlkepkvvd 1621 ledavpdskq leknseriek trgfmihkrr hethrdprtr vndwkeftnp itkkdakyqt 1681 arcmdcgtpf clsdtgcpls niipkfnell fknqwklald klletnnfpe ftgrvcpapc 1741 egactlgiie dpvgiksver iiidnafkeg wikpcppstr tgftvgvigs gpaglacadm 1801 lnraghtvtv yersdrcggl lmygipnmkl dkaivqrrid llsaegidfv tnteigktis 1861 mdelknkhna vvyaigstip rdlpikgrel knidfamqll esntkallnk dleiirekiq 1921 gkkvivvggg dtgndclgts vrhgaasvln fellpeppve rakdnpwpqw prvmrvdygh 1981 aevkehygrd preycilske figndegevt airtvrvewk ksqsgvwqmv eipnseeife 2041 adiillsmgf vgpelingnd nevkktrrgt iatlddssys idggktfacg dcrrgqsliv 2101 waiqegrkca asvdkflmdg ttylpsnggi vqrdykllke lasqv // LOCUS NP_010111 528 aa linear PLN 30-JUN-2025 DEFINITION Uga3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010111 VERSION NP_010111.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180230.1 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11691. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..528 /product="Uga3p" /calculated_mol_wt="61093" Region 15..>46 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(16,21..24,26,29,39) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(17,20,27,34,37,44) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 121..528 /region_name="Fungal_trans_2" /note="Fungal specific transcription factor domain; pfam11951" /db_xref="CDD:403235" CDS 1..528 /gene="UGA3" /locus_tag="YDL170W" /coded_by="NM_001180230.1:1..1587" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12235130]" /experiment="EXISTENCE:direct assay:GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [PMID:21515579]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:21515579]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19159085]" /experiment="EXISTENCE:genetic interaction:GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [PMID:21515579]" /experiment="EXISTENCE:mutant phenotype:GO:0009450 gamma-aminobutyric acid catabolic process [PMID:3888627]" /experiment="EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:7899074]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7899074]" /note="Transcriptional activator for GABA-dependent induction of GABA genes; binds to DNA elements found in the promoters of target genes and increases their expression in the presence of GABA (gamma-aminobutyrate); zinc finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus; examples of GABA genes include UGA1, UGA2, and UGA4" /db_xref="GeneID:851384" /db_xref="SGD:S000002329" ORIGIN 1 mnygveklkl kyskhgcitc kirkkrcsed kpvcrdcrrl sfpciyises vdkqslkkik 61 adiqhqlisk krkhapdsaq kaavatrtrr vgsdeqdnqv ylskpledci sqkldsmglq 121 lynyyrshla niisiapmnq nyylniflpm ahendgilfa ilawsanhls isssnelrkd 181 eifvnlanky tymslshlkt negssacakl gflyslaqil ilcgseicqg dvkfwkilln 241 igknlienhv gkdvsriltt tteepsleer iifpnfnsvv kywlivnfiy hdilnfntts 301 fpieqyekff qrdqnslpss anfiesidsp ieeidpligi nkpillllgq vtnltrflqt 361 meqeemlehg dkilslqvei yklqpslmal ehlddekkfy ylelfeimki stlmffqltl 421 lkidkdslel qilrnkldsk ldkvigtfle gslcfplfiy gvciqvedme kkidleakfd 481 dilkrykcyn fqnarllirk iwqneadgis ehdlvhmide ldyninfa // LOCUS NP_010112 223 aa linear PLN 30-JUN-2025 DEFINITION Ugx2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010112 VERSION NP_010112.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180229.1 REFERENCE 1 (residues 1 to 223) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 223) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 223) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 223) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11692. Method: conceptual translation. FEATURES Location/Qualifiers source 1..223 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..223 /product="Ugx2p" /calculated_mol_wt="25601" CDS 1..223 /gene="UGX2" /locus_tag="YDL169C" /coded_by="NM_001180229.1:1..672" /note="hypothetical protein; transcript accumulates in response to any combination of stress conditions" /db_xref="GeneID:851385" /db_xref="SGD:S000002328" ORIGIN 1 medkeklivy sntssvftys aeirpnfkis vsqsqgfawn qdlfatqyqq sykvvydahe 61 dnfdelilki kgklktksnk rakmksktkl trtakqrres pvcerdesde dndsdhyqri 121 qvldghefpr anryksvwah dvhsnedsts dgesnhdidm iggtgtsyag aaimdrprrk 181 sersisfved sktgdyryqt gqvdvvevds dtpennhlkw lik // LOCUS NP_010113 386 aa linear PLN 30-JUN-2025 DEFINITION bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010113 VERSION NP_010113.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180228.1 REFERENCE 1 (residues 1 to 386) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 386) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 386) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 386) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11693. Method: conceptual translation. FEATURES Location/Qualifiers source 1..386 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..386 /product="bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase" /EC_number="1.1.1.1" /EC_number="1.1.1.284" /calculated_mol_wt="40911" Region 10..381 /region_name="alcohol_DH_class_III" /note="class III alcohol dehydrogenases; cd08300" /db_xref="CDD:176260" Site order(49,51,60..62,71,97..98,179,302,326) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:176260" Site order(49,71..72,179) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176260" Site order(50..51,179,183,204..208,228..229,233,276..277, 281..282,300..301,325..327,377) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:176260" Site order(101,104,107,115) /site_type="other" /note="structural Zn binding site [ion binding]" /db_xref="CDD:176260" Site order(105..106,109,111..112,114,116,267,272,283..284, 291..294,303,306..313,316..318,321..326) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:176260" CDS 1..386 /gene="SFA1" /locus_tag="YDL168W" /gene_synonym="ADH5" /coded_by="NM_001180228.1:1..1161" /experiment="EXISTENCE:direct assay:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:8483449]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0046294 formaldehyde catabolic process [PMID:8483449]" /experiment="EXISTENCE:direct assay:GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity [PMID:8483449]" /experiment="EXISTENCE:genetic interaction:GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /experiment="EXISTENCE:mutant phenotype:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:12499363]" /experiment="EXISTENCE:mutant phenotype:GO:0033833 hydroxymethylfurfural reductase (NADH) activity [PMID:16652391]" /experiment="EXISTENCE:mutant phenotype:GO:0033859 furaldehyde metabolic process [PMID:16652391]" /note="Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851386" /db_xref="SGD:S000002327" ORIGIN 1 msaatvgkpi kciaavayda kkplsveeit vdapkahevr ikieytavch tdaytlsgsd 61 peglfpcvlg hegagivesv gddvitvkpg dhvialytae cgkckfctsg ktnlcgavra 121 tqgkgvmpdg ttrfhnakge diyhfmgcst fseytvvadv svvaidpkap ldaacllgcg 181 vttgfgaalk tanvqkgdtv avfgcgtvgl sviqgaklrg askiiaidin nkkkqycsqf 241 gatdfvnpke dlakdqtive kliemtdggl dftfdctgnt kimrdaleac hkgwgqsiii 301 gvaaageeis trpfqlvtgr vwkgsafggi kgrsemggli kdyqkgalkv eefithrrpf 361 keinqafedl hngdclrtvl ksdeik // LOCUS NP_010114 719 aa linear PLN 30-JUN-2025 DEFINITION Nrp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010114 VERSION NP_010114.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180227.1 REFERENCE 1 (residues 1 to 719) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 719) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 719) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 719) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11694. Method: conceptual translation. FEATURES Location/Qualifiers source 1..719 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..719 /product="Nrp1p" /calculated_mol_wt="79168" Region 226..328 /region_name="RRM_ARP_like" /note="RNA recognition motif (RRM) found in yeast asparagine-rich protein (ARP) and similar proteins; cd12452" /db_xref="CDD:409886" Region 355..384 /region_name="zf-RanBP" /note="Zn-finger in Ran binding protein and others; pfam00641" /db_xref="CDD:395516" Region 359..378 /region_name="RanBP2-type Zn finger" /note="RanBP2-type Zn finger [structural motif]" /db_xref="CDD:275376" Region 581..609 /region_name="zf-RanBP" /note="Zn-finger in Ran binding protein and others; pfam00641" /db_xref="CDD:395516" Region 585..604 /region_name="RanBP2-type Zn finger" /note="RanBP2-type Zn finger [structural motif]" /db_xref="CDD:275376" CDS 1..719 /gene="NRP1" /locus_tag="YDL167C" /coded_by="NM_001180227.1:1..2160" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:26777405]" /note="Putative RNA binding hypothetical protein; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis" /db_xref="GeneID:851387" /db_xref="SGD:S000002326" ORIGIN 1 mhyvvlelqv ahlpdtpkdq crianiafqi vnaetlvchy gtnslpsiev ngttkslesa 61 mvqldkdihd vignddfvlv slystwhirv tlprqarddg filtsylqhp kvfdlwkefd 121 rwcvnhpeil gqkkaisnnn cntksisina akntkdldei vrilevsipt eeagsvpeiy 181 sllkrttdil iqlhkkctsp edmesvltkp ydshtdiraf lqekskilym nnlppdttqs 241 eleswftqyg vrpvgfwtvk nivedtsnvn nnwslnnspy vedqdsisgf vvfqtheeat 301 evlalngrsi lsnlantkqp rvvehvlelq psstgvldka qeilspfpqs knkprpgdwn 361 cpscgfsnfq rrtacfrcsf papsnsqiht ansnnnvnss rnnlnnrvns gsssnisnta 421 anhpygapef nmianntpaa ltynrahfpa itplsrqnsl nmapsnsgsp iiiadhfsgn 481 nniapnyryn nninnnnnni nnmtnnryni nnningngng ngnnsnnnnn hnnnhnnnhh 541 ngsinsnsnt nnnnnnnngn nsnncnsnig mggcgsnmpf ragdwkcstc tyhnfaknvv 601 clrcggpksi sgdasetnhy idsstfgpas rtpsnnnisv ntnggsnagr tdgndnkgrd 661 islmefmspp lsmatksmke gdgngssfne fksdkanvnf snvgdnsafg ngfnssirw // LOCUS NP_010115 197 aa linear PLN 30-JUN-2025 DEFINITION nucleoside-triphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010115 VERSION NP_010115.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180226.1 REFERENCE 1 (residues 1 to 197) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 197) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 197) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11695. Method: conceptual translation. FEATURES Location/Qualifiers source 1..197 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..197 /product="nucleoside-triphosphatase" /EC_number="2.7.4.3" /calculated_mol_wt="22592" Region 10..179 /region_name="Fap7" /note="Broad-specificity NMP kinase [Nucleotide transport and metabolism]; COG1936" /db_xref="CDD:441539" CDS 1..197 /gene="FAP7" /locus_tag="YDL166C" /coded_by="NM_001180226.1:1..594" /experiment="EXISTENCE:direct assay:GO:0004017 AMP kinase activity [PMID:24823650]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10692169]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:24823650]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12837249|PMID:16287850]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:16287850]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10692169]" /note="Essential NTPase required for small ribosome subunit synthesis; mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p; complex with Rps14 is conserved between humans, yeast, and arches; may be the endonuclease for site D; depletion leads to accumulation of pre-40S ribosomes in 80S-like ribosomes; human TAF9 functionally complements the lethality of the null mutation" /db_xref="GeneID:851388" /db_xref="SGD:S000002325" ORIGIN 1 mearrygpni ivtgtpgcgk sstceflknk lkdykyynis dfakdndcfe gydegrkshi 61 vdedklldml epllrqgnsi vdwhvndvfp erlidlvvvl rcdnsnlysr lhargyhdsk 121 ieenldaeim gvvkqdaves yephivvelq sdtkedmvsn vsrivawekm wleqhpdgvt 181 neyqgprsdd eddedse // LOCUS NP_010116 191 aa linear PLN 30-JUN-2025 DEFINITION CCR4-NOT core subunit CDC36 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010116 VERSION NP_010116.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180225.1 REFERENCE 1 (residues 1 to 191) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 191) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 191) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 191) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11696. Method: conceptual translation. FEATURES Location/Qualifiers source 1..191 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..191 /product="CCR4-NOT core subunit CDC36" /calculated_mol_wt="22231" Region 5..191 /region_name="CDC36" /note="General negative regulator of transcription subunit [Transcription]; COG5601" /db_xref="CDD:227888" CDS 1..191 /gene="CDC36" /locus_tag="YDL165W" /gene_synonym="DNA19; NOT2" /coded_by="NM_001180225.1:1..576" /experiment="EXISTENCE:direct assay:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7926748]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11889048]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:26952104]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:2111445]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:11404327]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16926149]" /experiment="EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15706350]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:2111445]" /experiment="EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:10490603]" /note="Component of the CCR4-NOT core complex, involved in mRNA decapping; this complex has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs through deadenylation; basal transcription factor" /db_xref="GeneID:851389" /db_xref="SGD:S000002324" ORIGIN 1 mekfglkalv pllkledkel sstydhsmtl gadlssmlys lgiprdsqdh rvldtfqspw 61 aetsrsevep rfftpesftn ipgvlqstvt ppcfnsiqnd qqrvalfqde tlfflfykhp 121 gtviqeltyl elrkrnwryh ktlkawltkd pmmepivsad glsergsyvf fdpqrwekcq 181 rdfllfynai m // LOCUS NP_010117 755 aa linear PLN 30-JUN-2025 DEFINITION DNA ligase (ATP) CDC9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010117 VERSION NP_010117.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180224.1 REFERENCE 1 (residues 1 to 755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 755) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11697. Method: conceptual translation. FEATURES Location/Qualifiers source 1..755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..755 /product="DNA ligase (ATP) CDC9" /EC_number="6.5.1.1" /calculated_mol_wt="84698" Region 215..748 /region_name="dnl1" /note="DNA ligase I, ATP-dependent (dnl1); TIGR00574" /db_xref="CDD:273147" CDS 1..755 /gene="CDC9" /locus_tag="YDL164C" /gene_synonym="MMS8" /coded_by="NM_001180224.1:1..2268" /experiment="EXISTENCE:direct assay:GO:0003910 DNA ligase (ATP) activity [PMID:1445910|PMID:6347688]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10531002]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:10531002]" /experiment="EXISTENCE:direct assay:GO:0006273 lagging strand elongation [PMID:9759502]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:6749599]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:10531002]" /experiment="EXISTENCE:mutant phenotype:GO:0006273 lagging strand elongation [PMID:9759502]" /experiment="EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:10052932]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:10052932]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:9230305]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:16079237]" /note="DNA ligase I found in nucleus and mitochondria; essential enzyme that joins Okazaki fragments during DNA replication; also acts in ribonucleotide excision repair, base excision repair, and recombination; DNA ligase I mutants trigger ubiquitination of PCNA at K107, facilitating Rad59p-mediated bypass of unligated Okazaki fragments; human homolog LIG1 can complement yeast cdc9 temperature-sensitive mutant at restrictive temperature" /db_xref="GeneID:851391" /db_xref="SGD:S000002323" ORIGIN 1 mrrlltgcll ssarplksrl pllmssslps sagkkpkqat larfftsmkn kptegtpspk 61 ksskhmledr mdnvsgeeey atkklkqtav thtvaapssm gsnfssipss apssgvadsp 121 qqsqrlvgev edalssnnnd hyssnipyse vcevfnkiea issrleiiri csdffikimk 181 qssknliptt ylfinrlgpd yeaglelglg enllmktise tcgksmsqik lkykdigdlg 241 eiamgarnvq ptmfkpkplt vgevfknlra iaktqgkdsq lkkmklikrm ltackgieak 301 flirsleskl riglaektvl islskalllh denredspdk dvpmdvlesa qqkirdafcq 361 vpnyeivins clehgimnld kyctlrpgip lkpmlakptk ainevldrfq getftseyky 421 dgeraqvhll ndgtmriysr ngenmteryp einitdfiqd ldttknlild ceavawdkdq 481 gkilpfqvls trkrkdveln dvkvkvclfa fdilcynder linkslkerr eyltkvtkvv 541 pgefqyatqi ttnnldelqk fldesvnhsc eglmvkmleg peshyepskr srnwlklkkd 601 ylegvgdsld lcvlgayygr gkrtgtyggf llgcynqdtg efetcckigt gfsdemlqll 661 hdrltptiid gpkatfvfds saepdvwfep ttlfevltad lslspiykag satfdkgvsl 721 rfprflrire dkgvedatss dqivelyenq shmqn // LOCUS NP_010120 454 aa linear PLN 30-JUN-2025 DEFINITION epsin [Saccharomyces cerevisiae S288C]. ACCESSION NP_010120 VERSION NP_010120.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180221.1 REFERENCE 1 (residues 1 to 454) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 454) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 454) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 454) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11698. Method: conceptual translation. FEATURES Location/Qualifiers source 1..454 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..454 /product="epsin" /calculated_mol_wt="52221" Region 15..146 /region_name="ENTH_Ent1_Ent2" /note="Epsin N-Terminal Homology (ENTH) domain of Yeast Ent1, Ent2, and similar proteins; cd16991" /db_xref="CDD:340788" Site order(24,28..29,62,68,72) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:340788" Site order(60,63..64,100..101,103..110,123,127) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:340788" CDS 1..454 /gene="ENT1" /locus_tag="YDL161W" /coded_by="NM_001180221.1:1..1365" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:10449404]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:10449404]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12529323]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:10449404]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:31370222]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:10449404]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10449404]" /note="Epsin-like protein involved in endocytosis and actin patch assembly; K63-specific Ub chain binding protein that functions as an endocytic adaptor; binds clathrin via a clathrin-binding domain motif at C-terminus; contains two ubiquitin-interacting motifs (UIMs); functionally redundant with Ent2p; relocalizes from bud neck to cytoplasm upon DNA replication stress; ENT1 has a paralog, ENT2, that arose from the whole genome duplication" /db_xref="GeneID:851392" /db_xref="SGD:S000002320" ORIGIN 1 mskqfvrsak nlvkgysstq vlvrnatsnd nhqvskdsli elaeksydsa dffeimdmld 61 krlndkgkyw rhiakaltvi dylirfgsen cvlwcrenly iiktlkefrh eddegidqgq 121 ivrvkakelt allsdderln eernmnikgr nrkgrrrrgt grsdendddl qraisasrlt 181 aeederrrkq dedyetalql skeeeelkrl qdlqrmqqqq gqqqlqqpmy ydifgnpitp 241 eeyaqfqlqq qqqqqqqqlq qqpmyydvfg npitpeelaq fqqqqqlqeq qylasmqqqq 301 qamsnnpfak seqsssspkr nqlvaasspq qlqqqkqqep liqnrtgnqs mtdkysklne 361 llatgtgidt fgnvgearip aqhtktgtfi nsqgtgyrqv sddpnhnpfl nsqytglpst 421 svvptqtgyg fgnqsqqqsq nngsnnrgyt lidl // LOCUS NP_878060 80 aa linear PLN 30-JUN-2025 DEFINITION Mhf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878060 VERSION NP_878060.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184530.1 REFERENCE 1 (residues 1 to 80) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 80) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 80) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 80) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11699. Method: conceptual translation. FEATURES Location/Qualifiers source 1..80 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..80 /product="Mhf2p" /calculated_mol_wt="8919" Region 4..79 /region_name="CENP-X" /note="CENP-S associating Centromere protein X; pfam09415" /db_xref="CDD:462793" CDS 1..80 /gene="MHF2" /locus_tag="YDL160C-A" /coded_by="NM_001184530.1:1..243" /experiment="EXISTENCE:direct assay:GO:0071821 FANCM-MHF complex [PMID:22325783]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:20347428]" /note="Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2" /db_xref="GeneID:1466431" /db_xref="SGD:S000028520" ORIGIN 1 mlskealiki lsqneggndm kiadevvpmi qkyldifide avlrslqshk dingergdks 61 plelshqdle rivglllmdm // LOCUS NP_010121 506 aa linear PLN 30-JUN-2025 DEFINITION DExD/H-box ATP-dependent RNA helicase DHH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010121 VERSION NP_010121.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180220.1 REFERENCE 1 (residues 1 to 506) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 506) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 506) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 506) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11700. Method: conceptual translation. FEATURES Location/Qualifiers source 1..506 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..506 /product="DExD/H-box ATP-dependent RNA helicase DHH1" /EC_number="3.6.4.13" /calculated_mol_wt="57413" Region 47..406 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..506 /gene="DHH1" /locus_tag="YDL160C" /coded_by="NM_001180220.1:1..1521" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:12730603|PMID:18611963|PMID:20368989]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:12032091]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:20368989|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0010603 regulation of cytoplasmic mRNA processing body assembly [PMID:27692063]" /experiment="EXISTENCE:direct assay:GO:0098562 cytoplasmic side of membrane [PMID:27146487]" /experiment="EXISTENCE:genetic interaction:GO:0033962 P-body assembly [PMID:18981231]" /experiment="EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:genetic interaction:GO:0045900 negative regulation of translational elongation [PMID:22719226]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:11780629]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:18182159]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:30973873]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:32989641]" /experiment="EXISTENCE:mutant phenotype:GO:0010603 regulation of cytoplasmic mRNA processing body assembly [PMID:27692063]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:32989641]" /experiment="EXISTENCE:mutant phenotype:GO:0017148 negative regulation of translation [PMID:21844211]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:17041186]" /experiment="EXISTENCE:mutant phenotype:GO:0033962 P-body assembly [PMID:18182159]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:18981231|PMID:20368989]" /experiment="EXISTENCE:mutant phenotype:GO:0036267 invasive filamentous growth [PMID:32989641]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:17041186|PMID:30973873|PMID:18182159]" /experiment="EXISTENCE:mutant phenotype:GO:0045900 negative regulation of translational elongation [PMID:22719226]" /note="Cytoplasmic DEAD-box helicase and mRNA decapping activator; interacts with decapping and deadenylase complexes to coordinate mRNA decapping and decay; regulates general translational repression; translational activator of select mRNAs during filamentous growth, mating and autophagy; cooperates with Ngr1p to promote specific mRNA decay; ATP- and RNA-bound form promotes processing body assembly, while ATPase stimulation by Not1p promotes disassembly; forms cytoplasmic foci on replication stress" /db_xref="GeneID:851394" /db_xref="SGD:S000002319" ORIGIN 1 mgsinnnfnt nnnsntdldr dwktalnipk kdtrpqtddv lntkgntfed fylkrellmg 61 ifeagfekps piqeeaipva itgrdilara kngtgktaaf viptlekvkp klnkiqalim 121 vptrelalqt sqvvrtlgkh cgiscmvttg gtnlrddilr lnetvhilvg tpgrvldlas 181 rkvadlsdcs lfimdeadkm lsrdfktiie qilsflppth qsllfsatfp ltvkefmvkh 241 lhkpyeinlm eeltlkgitq yyafveerqk lhclntlfsk lqinqaiifc nstnrvella 301 kkitdlgysc yysharmkqq ernkvfhefr qgkvrtlvcs dlltrgidiq avnvvinfdf 361 pktaetylhr igrsgrfghl glainlinwn drfnlykieq elgteiaaip atidkslyva 421 endetvpvpf pieqqsyhqq aipqqqlpsq qqfaippqqh hpqfmvppsh qqqqaypppq 481 mpsqqgyppq qehfmamppg qsqpqy // LOCUS NP_076884 43 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL159W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_076884 VERSION NP_076884.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184465.1 REFERENCE 1 (residues 1 to 43) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 43) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 43) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 43) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11701. Method: conceptual translation. FEATURES Location/Qualifiers source 1..43 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..43 /product="uncharacterized protein" /calculated_mol_wt="4960" CDS 1..43 /locus_tag="YDL159W-A" /gene_synonym="YDL159W-B" /coded_by="NM_001184465.1:1..132" /note="hypothetical protein; identified by sequence comparison with hemiascomycetous yeast species" /db_xref="GeneID:851395" /db_xref="SGD:S000007599" ORIGIN 1 mynqiintfi ddclflqtpm lqspisskiv lsfflrnffp slf // LOCUS NP_010122 515 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase kinase STE7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010122 VERSION NP_010122.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180219.1 REFERENCE 1 (residues 1 to 515) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 515) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 515) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 515) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11702. Method: conceptual translation. FEATURES Location/Qualifiers source 1..515 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..515 /product="mitogen-activated protein kinase kinase STE7" /EC_number="2.7.12.2" /calculated_mol_wt="57578" Region 185..482 /region_name="PKc_Byr1_like" /note="Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; cd06620" /db_xref="CDD:270792" Site order(197..201,205,218,220,252,271..274,277..278,281,331, 333..336,338,348..349,352,364..367,369,396,405) /site_type="active" /db_xref="CDD:270792" Site order(197..201,203,205,218,220,252,271..274,277..278, 280..281,333,335..336,338,349) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270792" Site order(200..201,331,333..335,352,364..367,369,396,405) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270792" Site 348..369 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270792" CDS 1..515 /gene="STE7" /locus_tag="YDL159W" /coded_by="NM_001180219.1:1..1548" /experiment="EXISTENCE:direct assay:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:8668180]" /experiment="EXISTENCE:direct assay:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8384702]" /experiment="EXISTENCE:direct assay:GO:0004708 MAP kinase kinase activity [PMID:8384702|PMID:8668180]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11781566]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:17952059|PMID:11781566]" /experiment="EXISTENCE:direct assay:GO:0071507 pheromone response MAPK cascade [PMID:8384702|PMID:8455599|PMID:8159759]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:10880465]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:9363895]" /experiment="EXISTENCE:genetic interaction:GO:0071507 pheromone response MAPK cascade [PMID:8455599]" /experiment="EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:15456892]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:8001818]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:8643578]" /experiment="EXISTENCE:mutant phenotype:GO:0071507 pheromone response MAPK cascade [PMID:8384702|PMID:8159759]" /experiment="EXISTENCE:physical interaction:GO:0071507 pheromone response MAPK cascade [PMID:8668180]" /note="Signal transducing MAP kinase kinase; involved in pheromone response where it phosphorylates Fus3p; involved in the pseudohyphal/invasive growth pathway where it phosphorylates of Kss1p; phosphorylated by Ste11p; degraded by ubiquitin pathway" /db_xref="GeneID:851396" /db_xref="SGD:S000002318" ORIGIN 1 mfqrktlqrr nlkglnlnlh pdvgnngqlq ektethqgqs rieghvmsni naiqnnsnlf 61 lrrgikkklt ldafgddqai skpntvviqq pqnepvlvls slsqspcvss ssslstpcii 121 daysnnfgls psstnstpst iqglsniatp venehsislp pleeslspaa adlkdtlsgt 181 sngnyiqlqd lvqlgkigag nsgtvvkalh vpdskivakk tipveqnnst iinqlvrels 241 ivknvkphen iitfygayyn qhinneiiil meysdcgsld kilsvykrfv qrgtvsskkt 301 wfneltiski aygvlngldh lyrqykiihr dikpsnvlin skgqiklcdf gvskklinsi 361 adtfvgtsty msperiqgnv ysikgdvwsl glmiielvtg efplgghndt pdgildllqr 421 ivnepsprlp kdriyskemt dfvnrccikn ererssihel lhhdlimkyv spskddkfrh 481 wcrkikskik edkrikreal draklekkqs ersth // LOCUS NP_010124 118 aa linear PLN 30-JUN-2025 DEFINITION Dmo2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010124 VERSION NP_010124.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180217.1 REFERENCE 1 (residues 1 to 118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 118) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11703. Method: conceptual translation. FEATURES Location/Qualifiers source 1..118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..118 /product="Dmo2p" /calculated_mol_wt="13431" CDS 1..118 /gene="DMO2" /locus_tag="YDL157C" /gene_synonym="DBI1" /coded_by="NM_001180217.1:1..357" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:39753782]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:mutant phenotype:GO:0015035 protein-disulfide reductase activity [PMID:39753782]" /experiment="EXISTENCE:mutant phenotype:GO:0051131 chaperone-mediated protein complex assembly [PMID:39753782]" /note="Protein disulfide oxidoreductase; mitochondrial inner membrane protein involved in the formation of disulfide bonds in Tim17, as well as Tim22, and Cox20p, that chaperones the assembly of multimeric complexes including the TIM23 complex; contains a conserved redox active CxxC motif; localizes to the peroxisome in addition to the mitochondrial inner membrane" /db_xref="GeneID:851398" /db_xref="SGD:S000002316" ORIGIN 1 msnilavfnp ppqrelekee tmdcvpcqvm stmfsvgfgs ylasgkpfky gkkeakrgis 61 ltefekrnpq wwkvtlrsfg glliafgfvr gtegwlwhkn keyknykkls ndgetqan // LOCUS NP_010125 522 aa linear PLN 30-JUN-2025 DEFINITION Cmr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010125 VERSION NP_010125.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180216.1 REFERENCE 1 (residues 1 to 522) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 522) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 522) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 522) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11704. Method: conceptual translation. FEATURES Location/Qualifiers source 1..522 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..522 /product="Cmr1p" /calculated_mol_wt="59025" Region 234..521 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 244..281 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 293..329 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 336..376 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 393..436 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 447..478 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 486..513 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..522 /gene="CMR1" /locus_tag="YDL156W" /coded_by="NM_001180216.1:1..1569" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:22367945]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:22367945]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22367945|PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:2000001 regulation of DNA damage checkpoint [PMID:25817432]" /note="Nuclear protein with role in transcription, protein quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or DNA replication stress; INQ likely sequesters proteins involved in DNA metabolism for degradation or re-folding; also localizes to coding regions of transcribed genes; contains three WD domains (WD-40 repeat); human ortholog WDR76 also exhibits perinuclear localization under similar stress conditions" /db_xref="GeneID:851399" /db_xref="SGD:S000002315" ORIGIN 1 mpeltefqkk rlenikrnnd llkklhlsgv asqikheagv leksrapakk kqkttntrat 61 ksasptlptr rsrrlrgesa ddvkgipnvn dnqllkmgsp dgqdknfida ikekpvigdv 121 klsdlikded esallekfkr fnngnfssgd ffeeikkrqg dvtgmdefdl dlydvfqpne 181 ikityerisa tyfhpamekk liiagdtsgt vgfwnvrdep ladseedrme epditrvklf 241 tknvgridcf padtskillt sydgsirsvh lnnlqseevl tlkneyddsl gisdcqfsye 301 npnvlflttl ggefttfdtr vkkseynlrr ladkkigsma inpmrpyeia tgsldrtlki 361 wdtrnlvkkp ewsqyedyps heivstydsr lsvsavsysp tdgtlvcngy ddtirlfdvk 421 srdhlsakle pkltiqhncq tgrwtsilka rfkpnknvfa ianmkraidi ynsegqqlah 481 lptatvpavi swhplrnwia ggnssgkifl ftddsgtikq ee // LOCUS NP_010126 427 aa linear PLN 30-JUN-2025 DEFINITION B-type cyclin CLB3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010126 VERSION NP_010126.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180215.1 REFERENCE 1 (residues 1 to 427) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 427) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 427) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 427) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11705. Method: conceptual translation. FEATURES Location/Qualifiers source 1..427 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..427 /product="B-type cyclin CLB3" /calculated_mol_wt="49345" Region 4..421 /region_name="COG5024" /note="Cyclin [Cell division and chromosome partitioning]" /db_xref="CDD:227357" Site order(167..168,171..172,175..176,179,252..253,256..260, 263..265,282,285..286,289..290,293..294) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410271" CDS 1..427 /gene="CLB3" /locus_tag="YDL155W" /coded_by="NM_001180215.1:1..1284" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095|PMID:12972503]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12972503|PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:32553169]" /experiment="EXISTENCE:direct assay:GO:0007135 meiosis II [PMID:18423199]" /experiment="EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:1387566|PMID:16688214|PMID:11438663]" /experiment="EXISTENCE:genetic interaction:GO:1901673 regulation of mitotic spindle assembly [PMID:8319908]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:1427070]" /experiment="EXISTENCE:mutant phenotype:GO:0001932 regulation of protein phosphorylation [PMID:8455600|PMID:8388545]" /experiment="EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:8388545|PMID:8455600]" /note="B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress; CLB3 has a paralog, CLB4, that arose from the whole genome duplication" /db_xref="GeneID:851400" /db_xref="SGD:S000002314" ORIGIN 1 mhhnsqslss ghirspeden vapignlkhr tgslshissa hprvalsdvt nivatnssnn 61 siskpkvapi kerldsaaii eeerldansv aqrkeadhnd lltdreqeep veddgeseed 121 eeedqeplll qhyasdtlvw ehafrtyyrt tldpndddvy dvvmvaelsn eifeymrkle 181 dlykpnpyym dkqpelrwsf rstlidwivq vhekfqllpe tlylciniid rylckevvpv 241 nkfqlvgaas lfiaakyeei ncptikdfvy msencysrnd lldaertiln glefelgwpg 301 pmsflrrisk addyehdtrt lakyllesti mdhrlvsaqp swlaagayfl skiilgqnqw 361 slahvyysny tqeqilplat iilencryas krhnaiwrky ssrrylhssq ivakwialae 421 hrversn // LOCUS NP_010127 901 aa linear PLN 30-JUN-2025 DEFINITION MutS family protein MSH5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010127 VERSION NP_010127.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180214.1 REFERENCE 1 (residues 1 to 901) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 901) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 901) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 901) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11706. Method: conceptual translation. FEATURES Location/Qualifiers source 1..901 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..901 /product="MutS family protein MSH5" /calculated_mol_wt="102078" Region <224..897 /region_name="mutS1" /note="DNA mismatch repair protein MutS; TIGR01070" /db_xref="CDD:273427" Region 597..830 /region_name="ABC_MSH5_euk" /note="ATP-binding cassette domain of eukaryotic MutS5 homolog; cd03281" /db_xref="CDD:213248" Site 643..650 /site_type="other" /note="Walker A/P-loop" /db_xref="CDD:213248" Site order(646..647,649..651,687,722..723,758) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:213248" Site 684..687 /site_type="other" /note="Q-loop/lid" /db_xref="CDD:213248" Site 692..705 /site_type="other" /note="ABC transporter signature motif" /db_xref="CDD:213248" Site 718..723 /site_type="other" /note="Walker B" /db_xref="CDD:213248" Site 726..729 /site_type="other" /note="D-loop" /db_xref="CDD:213248" Site 754..760 /site_type="other" /note="H-loop/switch region" /db_xref="CDD:213248" CDS 1..901 /gene="MSH5" /locus_tag="YDL154W" /coded_by="NM_001180214.1:1..2706" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:8001134]" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:30467025]" /experiment="EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:30467025]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:30467025]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0062037 D-loop DNA binding [PMID:30467025]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15066280|PMID:8001134|PMID:9374523]" /experiment="EXISTENCE:physical interaction:GO:0062128 MutSgamma complex [PMID:9374523]" /note="Protein of the MutS family; forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans" /db_xref="GeneID:851401" /db_xref="SGD:S000002313" ORIGIN 1 mshewlisas etmrsignge glrdkgavva nndgefnegd tnreedssti fsfdfdeeiv 61 mcidfsggkl gcsildyhtk tlkafdqdyv vnkttisshd liddadmssn dislllglli 121 meanptvclv parledwifd yiktkcdein crlelqpikr fkkwdllqsl qlrghdnqti 181 lndilsnskf tttvtlgtvg cilanheqlg eyndstassn mvtgrlvqna fedvihgiry 241 idirdrmvld entisalhif ptahklghdk mmrngffsvf elfnqvssdy arrilkswli 301 npltnkkrie trysiirtll dkqnaiifsd lsqsikrcpd afgfinqlrs gkstlgtwsk 361 vasflekgia ifqlvsslkl gsdeanilhd iknkvdisal keclrkvetv idfdtsrdtk 421 tltintgvdn rldecrniyn hlegilldva retqifllnt mpqedckttk sleklvnavy 481 ipqlgylvti svlmeplldg ipnlqweeif rsseniyfkn grvleldety gdiygaisdf 541 eieilfslqe qilrrktqlt aynillsele illsfaqvsa ernyaepqlv edecileiin 601 grhalyetfl dnyipnstmi dgglfselsw ceqnkgriiv vtganasgks vyltqngliv 661 ylaqigcfvp aerarigiad kiltrirtqe tvyktqssfl ldsqqmaksl slatekslil 721 ideygkgtdi ldgpslfgsi mlnmsksekc priiacthfh elfnenvlte nikgikhyct 781 dilisqkynl letahvgedh esegitflfk vkegiskqsf giycakvcgl srdiveraee 841 lsrminrgdd vvqqcgnlte kemrefqknq eivkkflswd ldlettttse nlrlklknfl 901 r // LOCUS NP_010128 610 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein SAS10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010128 VERSION NP_010128.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180213.1 REFERENCE 1 (residues 1 to 610) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 610) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 610) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 610) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11707. Method: conceptual translation. FEATURES Location/Qualifiers source 1..610 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..610 /product="rRNA-processing protein SAS10" /calculated_mol_wt="70129" Region 220..296 /region_name="Sas10_Utp3" /note="Sas10/Utp3/C1D family; pfam04000" /db_xref="CDD:461123" Region 534..608 /region_name="Sas10" /note="Sas10 C-terminal domain; pfam09368" /db_xref="CDD:462775" CDS 1..610 /gene="SAS10" /locus_tag="YDL153C" /gene_synonym="UTP3" /coded_by="NM_001180213.1:1..1833" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9611201]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309|PMID:12837249]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /note="Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance; essential gene" /db_xref="GeneID:851403" /db_xref="SGD:S000002312" ORIGIN 1 mvrkgsnrtk tsevgdeinp yglnevddfa skrekvllgq stfgdsnkdd dhslledede 61 eevlamdedd esideredee eeeeeeldga aaykkifgrn letdqlpeed eengmldnen 121 awgstkgeyy gaddldddea akeiekealr qqkkhleeln mndyldeeee eewvksakef 181 dmgefknstk qadtktsitd ilnmddeard nylrtmfpef aplskeftel apkfdelkks 241 eenefnklkl ialgsylgti scyysillhe lhnnedftsm kghpvmekil ttkeiwrqas 301 elpssfdvne gdgseseeta nieafnekkl nelqnsedsd aedggkqkqe ideeeresde 361 eeeeedvdid dfeeyvaqsr lhskpktssm peaddfiese iadvdaqdkk arrrtlrfyt 421 skidqqenkk tdrfkgdddi pykerlferq qrlldearkr gmhdnngadl ddkdygsede 481 avsrsintqg endyyqqvqr gkqdkkisrk eahknaviaa regklaelae nvsgdgkrai 541 nyqilknkgl tpkrnkdnrn srvkkrkkyq kaqkklksvr avysggqsgv yegektgikk 601 gltrsvkfkn // LOCUS NP_010131 422 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase III subunit C53 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010131 VERSION NP_010131.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180210.1 REFERENCE 1 (residues 1 to 422) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 422) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 422) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 422) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11708. Method: conceptual translation. FEATURES Location/Qualifiers source 1..422 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..422 /product="DNA-directed RNA polymerase III subunit C53" /calculated_mol_wt="46536" Region 301..420 /region_name="RNA_pol_Rpc4" /note="RNA polymerase III RPC4; pfam05132" /db_xref="CDD:461558" CDS 1..422 /gene="RPC53" /locus_tag="YDL150W" /gene_synonym="RPC4" /coded_by="NM_001180210.1:1..1269" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:1406624]" /note="RNA polymerase III subunit C53" /db_xref="GeneID:851404" /db_xref="SGD:S000002309" ORIGIN 1 mssnkgngrl pslkdsssng ggsakpslkf kpkavarksk eereaaaskv kleeeskrgn 61 dkkhfnnknk rvtgaggqqr rmakylnnth vissgplaag nfvsekgdlr rgfiksegsg 121 sslvqkglet idngaessen eaedddnegv askskkkfnm gkefearnli ededdgesek 181 ssdvdmddee wrskrieqlf pvrpvrvrhe dvetvkreiq ealsekptre ptpsvktepv 241 gtglqsylee rerqvnekla dlglekefqs vdgkeaaael ellnadhqhi lrklkkmnnk 301 perfmvfqlp trlpaferpa vkeekedmet qasdpskkkk nikkkdtkda lstrelagkv 361 gsirvhksgk lsvkignvvm digkgaettf lqdvialsia ddassaellg rvdgkivvtp 421 qi // LOCUS NP_010132 997 aa linear PLN 30-JUN-2025 DEFINITION autophagy protein ATG9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010132 VERSION NP_010132.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180209.1 REFERENCE 1 (residues 1 to 997) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 997) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 997) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 997) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 997) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 997) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 997) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 997) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 997) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11709. Method: conceptual translation. FEATURES Location/Qualifiers source 1..997 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..997 /product="autophagy protein ATG9" /calculated_mol_wt="115272" Region 295..776 /region_name="ATG9" /note="Autophagy protein ATG9; pfam04109" /db_xref="CDD:461177" CDS 1..997 /gene="ATG9" /locus_tag="YDL149W" /gene_synonym="APG9; AUT9; CVT6; CVT7" /coded_by="NM_001180209.1:1..2994" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569|PMID:23129774|PMID:16874040]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16874040]" /experiment="EXISTENCE:direct assay:GO:0017128 phospholipid scramblase activity [PMID:33106658]" /experiment="EXISTENCE:direct assay:GO:0030659 cytoplasmic vesicle membrane [PMID:23129774]" /experiment="EXISTENCE:direct assay:GO:0045332 phospholipid translocation [PMID:33106658]" /experiment="EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:33106658|PMID:24881874|PMID:10662773|PMID:23129774]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:10662773]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:23129774]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]" /note="Lipid scramblase that mediates autophagosomal membrane expansion; translocates phospholipids between outer and inner leaflets of liposomes; transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between phagophore assembly site (PAS) and other cytosolic punctate structures" /db_xref="GeneID:851406" /db_xref="SGD:S000002308" ORIGIN 1 merdeyqlpn shgkntflsr ifglqsdevn pslnsqemsn fplpdiergs sllhstndsr 61 edvdendlrv pesdqgtste eedevdeeqv qayapqisdg ldgdhqlnsv tskenvlete 121 ksnlerlveg stddsvpkvg qlsseeeedn efinndgfdd dtplfqkski hefsskksnt 181 iedgkrplff rhilqnnrpq rdtqklftss naihhdkdks anngprning nqkhgtkyfg 241 satqprftgs plnntnrftk lfplrkpnll snisvlnntp edrintlsvk eralwkwanv 301 enldiflqdv ynyylgngfy ciilekilni ctllfvvfvs tymghcvdys klptshrvsd 361 iiidkcysns itgftkfflw mfyffvilki vqlyfdvqkl selqnfykyl lnisddelqt 421 lpwqnviqql mylkdqnamt anvvevkakn ridahdvanr imrrenylia lynsdilnls 481 lpiplfrtnv ltktlewnin lcvmgfvfne sgfikqsilk psqreftree lqkrfmlagf 541 lniilapflv tyfvllyffr yfneyktspg sigarqytpi aewkfreyne lyhifkkris 601 lsttlankyv dqfpkektnl flkfvsficg sfvailaflt vfdpenflnf eitsdrsvif 661 yitilgaiws vsrntitqey hvfdpeetlk elyeythylp kewegryhke eiklefckly 721 nlrivillre ltslmitpfv lwfslpssag rivdffrens eyvdglgyvc kyamfnmkni 781 dgedthsmde dsltkkiavn gshtlnskrr skftaedhsd kdlannkmlq syvyfmddys 841 nsenltgkyq lpakkgypnn egdsflnnky swrkqfqpgq kpelfrigkh algpghnisp 901 aiystrnpgk nwdnnnngdd ikngtnnata knddnngnnd heyvltesfl dsgafpnhdv 961 idhnkmlnsn yngngilnkg gvlglvkeyy kksdvgr // LOCUS NP_010133 810 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-binding rRNA-processing protein NOP14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010133 VERSION NP_010133.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180208.1 REFERENCE 1 (residues 1 to 810) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 810) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 810) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 810) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11710. Method: conceptual translation. FEATURES Location/Qualifiers source 1..810 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..810 /product="snoRNA-binding rRNA-processing protein NOP14" /calculated_mol_wt="94171" Region 48..794 /region_name="Nop14" /note="Nop14-like family; pfam04147" /db_xref="CDD:461196" CDS 1..810 /gene="NOP14" /locus_tag="YDL148C" /gene_synonym="UTP2" /coded_by="NM_001180208.1:1..2433" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247|PMID:12150911|PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11694595]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:11694595]" /experiment="EXISTENCE:physical interaction:GO:0030692 Noc4p-Nop14p complex [PMID:12446671]" /note="Nucleolar protein; forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA" /db_xref="GeneID:851407" /db_xref="SGD:S000002307" ORIGIN 1 magsqlknlk aalkargltg qtnvksknkk nskrqakeyd reekkkaiae ireefnpfei 61 kaarnkrrdg lpsktadria vgkpgiskqi geeqrkrafe arkmmknkrg gvidkrfger 121 dkllteeekm lerftrerqs qskrnanlfn leddeddgdm fgdglthlgq slsledelan 181 deedflaskr fneddaelqq pqrkktkaev mkeviakskf ykqerqkaqg imedqidnld 241 dnfedvmsel mmtqpkknpm epktdldkey dikvkelqld kraapsdrtk teeeknaeae 301 ekkreleqqr ldrmngmiel eegeergved lddgfwenee dyeddndgia dsdddikfed 361 qgrdegfsqi lkkknisisc prthdalldq vkkldlddhp kivkniikay qpklaegnke 421 klgkftavll rhiiflsnqn ylknvqsfkr tqnalisilk slsekynrel seecrdyine 481 mqarykknhf dalsngdlvf fsiigilfst sdqyhlvitp alilmsqfle qikfnslkri 541 afgavlvriv sqyqriskry ipevvyffqk illtfiveke nqekpldfen irldsyelgl 601 pldvdftkkr stiiplhtls tmdteahpvd qcvsvllnvm esldatistv wkslpafnei 661 ilpiqqllsa ytskysdfek prnilnkvek ltkftehipl alqnhkpvsi pthapkyeen 721 fnpdkksydp drtrseinkm kaqlkkerkf tmkeirkdak fearqrieek nkessdyhak 781 mahivntint eegaeknkye rerklrggkk // LOCUS NP_010134 445 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle lid subunit RPN5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010134 VERSION NP_010134.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180207.1 REFERENCE 1 (residues 1 to 445) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 445) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 445) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 445) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11711. Method: conceptual translation. FEATURES Location/Qualifiers source 1..445 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..445 /product="proteasome regulatory particle lid subunit RPN5" /calculated_mol_wt="51638" Region 5..445 /region_name="RPN5" /note="26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]; COG5071" /db_xref="CDD:227403" CDS 1..445 /gene="RPN5" /locus_tag="YDL147W" /gene_synonym="NAS5" /coded_by="NM_001180207.1:1..1338" /experiment="EXISTENCE:direct assay:GO:0000502 proteasome complex [PMID:21289098]" /experiment="EXISTENCE:direct assay:GO:0008180 COP9 signalosome [PMID:21289098]" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:9741626|PMID:11742986]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:mutant phenotype:GO:0000338 protein deneddylation [PMID:21289098]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27226596]" /note="Subunit of the CSN and 26S proteasome lid complexes; similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein; the COP9 signalosome is also known as the CSN" /db_xref="GeneID:851408" /db_xref="SGD:S000002306" ORIGIN 1 msrdapikad kdysqilkee fpkidslaqn dcnsaldqll vlekktrqas dlasskevla 61 kivdllasrn kwddlneqlt llskkhgqlk lsiqymiqkv meylkssksl dlntrisvie 121 tirvvtenki fveverarvt kdlveikkee gkideaadil celqvetygs memsekiqfi 181 leqmelsilk gdysqatvls rkilkktfkn pkyeslkley ynllvkislh kreylevaqy 241 lqeiyqtdai ksdeakwkpv lshivyflvl spygnlqndl ihkiqndnnl kklesqeslv 301 klfttnelmr wpivqktyep vlneddlafg geankhhwed lqkrviehnl rviseyysri 361 tllrlnelld ltesqtetyi sdlvnqgiiy akvnrpakiv nfekpknssq llnewshnvd 421 ellehietig hlitkeeimh glqak // LOCUS NP_010135 491 aa linear PLN 30-JUN-2025 DEFINITION Ldb17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010135 VERSION NP_010135.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180206.1 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11712. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..491 /product="Ldb17p" /calculated_mol_wt="56418" Region 236..372 /region_name="SPIN90_LRD" /note="SPIN90/Ldb17, leucine-rich domain; pfam09431" /db_xref="CDD:462796" CDS 1..491 /gene="LDB17" /locus_tag="YDL146W" /coded_by="NM_001180206.1:1..1476" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:19506040]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:19506040]" /note="Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck" /db_xref="GeneID:851409" /db_xref="SGD:S000002305" ORIGIN 1 mildplspni enhtqdeiie fwektesian ipkenldesh vnsslvaylk fatdsykvfi 61 ntdrdlyrms lillesslfe fkkefclskl qsllnidlle mnmkfiivyi llceakknvy 121 sleimlkfqg ftvfyntlyt qfaylskygk ertvaskhqy nsnnsstgts ldsldrsltd 181 idlgiidemk qistvlmdll fqimkyckcv ianlqivddf fvyymmesmr sdtmddmfnn 241 aefklllaln eqymmfakey dienkvykyl ingsvsrcft ellllkfnra sdpplqimmc 301 kiiyliltpr gdyspmnffy tndlrvlidv lirelqnise deevlrntll rvlipllknt 361 qlskthyrkd dlnkllnyls tldnicvdsp alhehqvtva lsrkclqqip wletpstpsd 421 ggssvssnnt srnssivalg tpdnqnilar kghlysnrel dvsaesltkr kakapppppp 481 pppsrkcgtp k // LOCUS NP_010136 1201 aa linear PLN 30-JUN-2025 DEFINITION coatomer subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_010136 VERSION NP_010136.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180205.1 REFERENCE 1 (residues 1 to 1201) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1201) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1201) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1201) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11713. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1201 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1201 /product="coatomer subunit alpha" /calculated_mol_wt="135477" Region 17..322 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Region 17..51 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Site order(28,32,38..39,51..52,70,74,80..81,93..94,111,116, 122..123,136,153,158,164..165,207..208,226,230,236..237, 251..252,269,274,280..281,293..294,311,315,321..322) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 59..93 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 99..135 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 140..206 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 213..250 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 256..292 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 328..777 /region_name="Coatomer_WDAD_alpha" /note="Coatomer WD Associated Region from Coatomer Subunit Alpha; cd22948" /db_xref="CDD:438573" Region 328..341 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438573" Region 371..416 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438573" Region 419..442 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438573" Region 463..492 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438573" Region 495..527 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438573" Region 543..569 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438573" Region 571..596 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438573" Site order(742..744,764..765,767..770) /site_type="active" /note="coatomer subunit alpha binding site [active]" /db_xref="CDD:438573" Region 829..1199 /region_name="COPI_C" /note="Coatomer (COPI) alpha subunit C-terminus; pfam06957" /db_xref="CDD:462050" CDS 1..1201 /gene="COP1" /locus_tag="YDL145C" /gene_synonym="RET1; SEC33; SOO1" /coded_by="NM_001180205.1:1..3606" /experiment="EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:21435344]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9427388]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8001155]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:27068463]" /experiment="EXISTENCE:mutant phenotype:GO:0030126 COPI vesicle coat [PMID:8001155]" /note="Alpha subunit of COPI vesicle coatomer complex; complex surrounds transport vesicles in the early secretory pathway" /db_xref="GeneID:851410" /db_xref="SGD:S000002304" ORIGIN 1 mkmltkfesk strakgiafh psrpwvlval fsstiqlwdy rmgtllhrfe dhegpvrgld 61 fhptqpifvs agddytikvw sldtnkclyt ltghldyvrt vffhrelpwi isasddqtir 121 iwnwqnrkei acltghnhfv mcaqfhptdd livsasldet iriwdisglr krhsapgtss 181 feeqmsaqqn lldgslgdcv vkfileghtr gvnwasfhpt lplivsgsdd rqvklwrmsa 241 tkawevdtcr ghtnnvdsvi fhphqnliis vgedktlrvw dldkrtpvkq fkrendrfwl 301 iaahphinlf gaahdsgimv fkldrerpcs fihqnqlffv naekqiqsfn fqkrvaslpy 361 aslkgigqpw dafrsisynp sqhsvlvnea ngkfalvilp kqpvgavept svtqdtgnfa 421 tfvgrnrfvv ynkntesvev rslenkvtrn ikveetvrti vaagpgsvlv ihprevilyd 481 vqqgkkvsql avknvkyvsw sldgqyvalm skhtitlatk klelinsmhe tiriksaawd 541 etgvliystl nhirysllng drgiiktlek tlyitkvqgk lvyclnrege ieiltidpte 601 yrfkkalvnk nfpevlrlik dsnlvgqnii sylqksgype ialqfvqdph irfdlaleyg 661 nldvaldeak klndsstwer liqealaqgn aslaemiyqt qhsfdklsfl ylvtgdvnkl 721 skmqniaqtr edfgsmllnt fynnstkers sifaeggslp layavakang deaaasafle 781 qaevdeqdvt lpdqmdasnf vqrpviskpl ekwplkeael syfekavlgq iddltiddet 841 pavnttqeqe eplgeenfnd edigedegaw dlgdedldvg eelpeeveqg eitspaqeve 901 taiwiknskl pavlvaagaf daavqalskq vgvvkleplk kyftniyegc rtyipstpce 961 lpaqlgyvra yddtvsedqi lpyvpgldvv nekmnegykn fklnkpdiai ecfreaiyri 1021 tllmvddaed eklahkilet areyilglsi elerrslkeg ntvrmlelaa yftkaklspi 1081 hrtnalqvam sqhfkhknfl qasyfagefl kiissgprae qarkiknkad smasdaipid 1141 fdpyakfdic aatykpiyed tpsvsdpltg skyvitekdk idriamiski gapasglrir 1201 v // LOCUS NP_010137 356 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL144C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010137 VERSION NP_010137.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180204.1 REFERENCE 1 (residues 1 to 356) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 356) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 356) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 356) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11714. On Oct 2, 2003 this sequence version replaced NP_010137.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..356 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..356 /product="uncharacterized protein" /calculated_mol_wt="39652" Region 3..341 /region_name="PanE" /note="Ketopantoate reductase [Coenzyme transport and metabolism]; COG1893" /db_xref="CDD:441497" CDS 1..356 /locus_tag="YDL144C" /coded_by="NM_001180204.1:1..1071" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851411" /db_xref="SGD:S000002303" ORIGIN 1 msrilvigag gvgvitalsl wlkkesdvsl vvrsdydrvl khgytiescd ygrlegwrph 61 hiyssvedaa saadnqgyny ivvttkniid gpvnsrvsni irpvleknke lhgpqltthi 121 llvqngidie keiwaefpre qyrytvlsgi qligstkigs ghisqvgqdh lscgafdpqd 181 aaaiqaandf vrmysnegqn fvefdprvry srwkkllyna aintstalvg ldvprclefg 241 vnkksteiev fhpamreiia iaasegiiie eefitmftei trkkvfkpsm cvdcekgqlm 301 elevilgnpi riakrngvat ptlsilynll vlvqaklker kgllkfdekt atlvde // LOCUS NP_010138 528 aa linear PLN 30-JUN-2025 DEFINITION chaperonin-containing T-complex subunit CCT4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010138 VERSION NP_010138.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180203.1 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11715. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..528 /product="chaperonin-containing T-complex subunit CCT4" /calculated_mol_wt="57473" Region 11..528 /region_name="chap_CCT_delta" /note="T-complex protein 1, delta subunit; TIGR02342" /db_xref="CDD:274083" Site order(12,16,44..47,49,67,69,73,77,80,384,520..526) /site_type="other" /note="ring oligomerisation interface [polypeptide binding]" /db_xref="CDD:239454" Site order(39..41,91,95,156,396,414,454,497,499) /site_type="other" /note="ATP/Mg binding site [chemical binding]" /db_xref="CDD:239454" Site order(434,452,461,463..464,467) /site_type="active" /note="stacking interactions [active]" /db_xref="CDD:239454" CDS 1..528 /gene="CCT4" /locus_tag="YDL143W" /gene_synonym="ANC2; TCP4" /coded_by="NM_001180203.1:1..1587" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo" /db_xref="GeneID:851412" /db_xref="SGD:S000002302" ORIGIN 1 msakvpsnat fknkekpqev rkaniiaars vadairtslg pkgmdkmikt srgeiiisnd 61 ghtilkqmai lhpvarmlve vsaaqdseag dgttsvvilt gallgaaerl lnkgihptii 121 adsfqsaakr svdillemch kvslsdreql vraastslss kivsqyssfl aplavdsvlk 181 isdensknvd lndirlvkkv ggtiddtemi dgvvltqtai ksaggptrke kakigliqfq 241 isppkpdten niivndyrqm dkilkeeray llnickkikk akcnvlliqk silrdavndl 301 alhflsklni mvvkdieree ieflskglgc kpiadielft edrlgsadlv eeidsdgski 361 vrvtgirnnn arptvsvvir gannmiidet erslhdalcv irclvkergl iagggapeie 421 isrrlskear smegvqafiw qefasalevi pttlaenagl nsikvvtelr skhengelnd 481 gisvrrsgtt ntyeehilqp vlvstsaitl asecvksilr iddiafsr // LOCUS NP_010139 283 aa linear PLN 30-JUN-2025 DEFINITION cardiolipin synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010139 VERSION NP_010139.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180202.1 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11716. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..283 /product="cardiolipin synthase" /EC_number="2.7.8.41" /calculated_mol_wt="31889" Region 61..283 /region_name="PgsA" /note="Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; COG0558" /db_xref="CDD:440324" CDS 1..283 /gene="CRD1" /locus_tag="YDL142C" /gene_synonym="CLS1" /coded_by="NM_001180202.1:1..852" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0008610 lipid biosynthetic process [PMID:7564918]" /experiment="EXISTENCE:direct assay:GO:0043337 cardiolipin synthase (CMP-forming) [PMID:7564918]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:25843549]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:26235513]" /experiment="EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:27402848]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:18799619]" /experiment="EXISTENCE:mutant phenotype:GO:0007006 mitochondrial membrane organization [PMID:10777514]" /experiment="EXISTENCE:mutant phenotype:GO:0008610 lipid biosynthetic process [PMID:9614098]" /experiment="EXISTENCE:mutant phenotype:GO:0043337 cardiolipin synthase (CMP-forming) [PMID:9614098]" /note="Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function and for correct integration of membrane-multispanning proteins into the mitochondrial outer membrane; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis" /db_xref="GeneID:851413" /db_xref="SGD:S000002301" ORIGIN 1 miqmvpiysc sallrrtipk rpfyhvlsgl tvrfkvnpql nynlfrdltr reyatnpskt 61 phikskllni pniltlsrig ctpfiglfii tnnltpalgl fafssitdfm dgyiarkygl 121 ktiagtildp ladkllmitt tlalsvpsgp qiipvsiaai ilgrdvllai salfirystl 181 klkypgrvaw nsywdivryp saevrpsqls kwntffqmvy lgsgvlllly ekeegcekte 241 edfedrkqdf qkafsylgyv tatttimsgv syalkrnafk llk // LOCUS NP_010140 690 aa linear PLN 30-JUN-2025 DEFINITION biotin--[acetyl-CoA-carboxylase] ligase BPL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010140 VERSION NP_010140.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180201.1 REFERENCE 1 (residues 1 to 690) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 690) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 690) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 690) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11717. Method: conceptual translation. FEATURES Location/Qualifiers source 1..690 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..690 /product="biotin--[acetyl-CoA-carboxylase] ligase BPL1" /EC_number="6.3.4.9" /EC_number="6.3.4.10" /EC_number="6.3.4.11" /EC_number="6.3.4.15" /calculated_mol_wt="76232" Region 1..280 /region_name="BPL_N" /note="Biotin-protein ligase, N terminal; pfam09825" /db_xref="CDD:462915" Region 388..591 /region_name="BPL" /note="biotin protein ligase; cd16442" /db_xref="CDD:319741" Site order(392..394,419,422..425,428..431,439..441,488,492,494, 529,532,534,549..551,553) /site_type="active" /db_xref="CDD:319741" Site 529 /site_type="active" /note="catalytic site [active]" /db_xref="CDD:319741" CDS 1..690 /gene="BPL1" /locus_tag="YDL141W" /gene_synonym="ACC2" /coded_by="NM_001180201.1:1..2073" /experiment="EXISTENCE:direct assay:GO:0004077 biotin--[biotin carboxyl-carrier protein] ligase activity [PMID:10551847]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0036211 protein modification process [PMID:10551847]" /experiment="EXISTENCE:mutant phenotype:GO:0004077 biotin--[biotin carboxyl-carrier protein] ligase activity [PMID:6108218]" /experiment="EXISTENCE:mutant phenotype:GO:0036211 protein modification process [PMID:6108218]" /note="Biotin:apoprotein ligase; covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon; human homolog HLCS can complement yeast BPL1 mutant" /db_xref="GeneID:851414" /db_xref="SGD:S000002300" ORIGIN 1 mnvlvyngpg ttpgsvkhav eslrdflepy yavstvnvkv lqtepwmskt savvfpggad 61 lpyvqacqpi isrlkhfvsk qggvfigfca ggyfgtsrve faqgdptmev sgsrdlrffp 121 gtsrgpayng fqynseagar avklnlpdgs qfstyfngga vfvdadkfdn veilatyaeh 181 pdvpssdsgk gqsenpaavv lctvgrgkvl ltgphpefnv rfmrkstdkh fletvvenlk 241 aqeimrlkfm rtvltktgln cnndfnyvra pnltplfmas apnkrnylqe mennlahhgm 301 hannvelcse lnaetdsfqf yrgyrasyda asssllhkep devpktvifp gvdedippfq 361 ytpnfdmkey fkylnvqnti gslllygevv tststilnnn ksllssipes tllhvgtiqv 421 sgrgrggntw inpkgvcast avvtmplqsp vtnrnisvvf vqylsmlayc kailsyapgf 481 sdipvrikwp ndlyalspty ykrknlklvn tgfehtklpl gdiepaylki sgllvnthfi 541 nnkyclllgc ginltsdgpt tslqtwidil neerqqlhld llpaikaekl qalymnnlev 601 ilkqfinyga aeilpsyyel wlhsnqivtl pdhgntqami tgitedygll iakelvsgss 661 tqftgnvynl qpdgntfdif ksliakkvqs // LOCUS NP_010141 1733 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase II core subunit RPO21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010141 VERSION NP_010141.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180200.1 REFERENCE 1 (residues 1 to 1733) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1733) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1733) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1733) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11718. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1733 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1733 /product="DNA-directed RNA polymerase II core subunit RPO21" /EC_number="2.7.7.6" /calculated_mol_wt="191481" Region 15..853 /region_name="RNAP_II_RPB1_N" /note="Largest subunit (Rpb1) of eukaryotic RNA polymerase II (RNAP II), N-terminal domain; cd02733" /db_xref="CDD:259848" Site order(22,26,29..30,77..79,81,92,236,238,240,245..246,304, 325,328..329,332,339,342,344..351,356..358,370,373..374, 443,445,447,451..452,454..455,466..467,469,472,481..484, 486,488,490,493..494,497,500..501,504..505,510,525..526, 529,657..658,746,751..752,757,760..761,770..771,801..802, 804..806,809..810,813..814,816..818,821..822,824..825, 838..839,842,846) /site_type="other" /note="RPB1 - RPB2 interface [polypeptide binding]" /db_xref="CDD:259848" Site order(22..35,38,79..104,231..250,288..294,297..305, 324..340,342..346) /site_type="other" /note="clamp" /db_xref="CDD:259848" Site order(38..42,75,248,250,256..261,263..265,267..268,271,275, 291,294..295,298..299,308..313,316..321,323,328,333,404, 407,411..414,416..418) /site_type="other" /note="RPB1-TFIIB interface [polypeptide binding]" /db_xref="CDD:259848" Site order(67,70,77,80) /site_type="other" /note="Zn-binding [ion binding]" /db_xref="CDD:259848" Site order(100..101,332,337,344,350,446..448,481,483,485, 835..836) /site_type="active" /note="active site region [active]" /db_xref="CDD:259848" Region 873..1056 /region_name="RNA_pol_Rpb1_6" /note="RNA polymerase Rpb1, domain 6; pfam04992" /db_xref="CDD:461511" Region 1035..1446 /region_name="RNAP_II_Rpb1_C" /note="Largest subunit (Rpb1) of Eukaryotic RNA polymerase II (RNAP II), C-terminal domain; cd02584" /db_xref="CDD:132720" Site order(1054..1055,1059,1062,1438,1441..1444,1446) /site_type="other" /note="Rpb1 - Rpb6 interaction site [polypeptide binding]" /db_xref="CDD:132720" Site order(1059..1089,1091..1121,1127..1141,1275,1282..1286, 1287..1291,1296..1357,1360..1379,1381..1395) /site_type="active" /note="cleft [active]" /db_xref="CDD:132720" Site order(1063,1066,1265,1269,1410,1420..1422,1428..1429,1431, 1433,1438) /site_type="other" /note="Rpb1 - Rpb2 interaction site [polypeptide binding]" /db_xref="CDD:132720" Site order(1108,1386,1403..1404,1407) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:132720" Site order(1318,1324..1325,1327,1337..1343,1345,1365,1376..1377, 1379) /site_type="other" /note="Rpb1 - Rpb5 interaction site [polypeptide binding]" /db_xref="CDD:132720" Site 1395..1436 /site_type="active" /note="clamp [active]" /db_xref="CDD:132720" Region 1698..1709 /region_name="RNA_pol_Rpb1_R" /note="RNA polymerase Rpb1 C-terminal repeat; pfam05001" /db_xref="CDD:461513" CDS 1..1733 /gene="RPO21" /locus_tag="YDL140C" /gene_synonym="RPB1; RPB220; SIT1; SUA8" /coded_by="NM_001180200.1:1..5202" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:26945063]" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:8288647]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:2186966|PMID:1331084|PMID:2183013]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:3299050]" /experiment="EXISTENCE:mutant phenotype:GO:0019985 translesion synthesis [PMID:22405652]" /note="RNA polymerase II largest subunit B220; part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime" /db_xref="GeneID:851415" /db_xref="SGD:S000002299" ORIGIN 1 mvgqqyssap lrtvkevqfg lfspeevrai svakirfpet mdetqtraki gglndprlgs 61 idrnlkcqtc qegmnecpgh fghidlakpv fhvgfiakik kvcecvcmhc gkllldehne 121 lmrqalaikd skkrfaaiwt lcktkmvcet dvpseddptq lvsrggcgnt qptirkdglk 181 lvgswkkdra tgdadepelr vlsteeilni fkhisvkdft slgfnevfsr pewmiltclp 241 vppppvrpsi sfnesqrged dltfkladil kanisletle hngaphhaie eaesllqfhv 301 atymdndiag qpqalqksgr pvksirarlk gkegrirgnl mgkrvdfsar tvisgdpnle 361 ldqvgvpksi aktltypevv tpynidrltq lvrngpnehp gakyvirdsg dridlryskr 421 agdiqlqygw kverhimdnd pvlfnrqpsl hkmsmmahrv kvipystfrl nlsvtspyna 481 dfdgdemnlh vpqseetrae lsqlcavplq ivspqsnkpc mgivqdtlcg irkltlrdtf 541 ieldqvlnml ywvpdwdgvi ptpaiikpkp lwsgkqilsv aipngihlqr fdegttllsp 601 kdngmliidg qiifgvvekk tvgssnggli hvvtrekgpq vcaklfgniq kvvnfwllhn 661 gfstgigdti adgptmreit etiaeakkkv ldvtkeaqan lltakhgmtl resfednvvr 721 flneardkag rlaevnlkdl nnvkqmvmag skgsfiniaq msacvgqqsv egkriafgfv 781 drtlphfskd dyspeskgfv ensylrgltp qefffhamgg reglidtavk taetgyiqrr 841 lvkaledimv hydnttrnsl gnviqfiyge dgmdaahiek qsldtiggsd aafekryrvd 901 llntdhtldp sllesgseil gdlklqvlld eeykqlvkdr kflrevfvdg eanwplpvni 961 rriiqnaqqt fhidhtkpsd ltikdivlgv kdlqenllvl rgkneiiqna qrdavtlfcc 1021 llrsrlatrr vlqeyrltkq afdwvlsnie aqflrsvvhp gemvgvlaaq sigepatqmt 1081 lntfhfagva skkvtsgvpr lkeilnvakn mktpsltvyl epghaadqeq aklirsaieh 1141 ttlksvtias eiyydpdprs tvipedeeii qlhfslldee aeqsfdqqsp wllrleldra 1201 amndkdltmg qvgerikqtf kndlfviwse dndekliirc rvvrpkslda eteaeedhml 1261 kkientmlen itlrgvenie rvvmmkydrk vpsptgeyvk epewvletdg vnlsevmtvp 1321 gidptriytn sfidimevlg ieagraalyk evynviasdg syvnyrhmal lvdvmttqgg 1381 ltsvtrhgfn rsntgalmrc sfeetveilf eagasaeldd crgvsenvil gqmapigtga 1441 fdvmideesl vkympeqkit eiedgqdggv tpysnesglv nadldvkdel mfsplvdsgs 1501 ndamaggfta yggadygeat spfgaygeap tspgfgvssp gfsptsptys ptspayspts 1561 psysptspsy sptspsyspt spsysptsps ysptspsysp tspsysptsp sysptspsys 1621 ptspsyspts psysptspsy sptspsyspt spsysptspa ysptspsysp tspsysptsp 1681 sysptspsys ptspnyspts psysptspgy spgspayspk qdeqkhnene nsr // LOCUS NP_010142 223 aa linear PLN 30-JUN-2025 DEFINITION Scm3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010142 VERSION NP_010142.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180199.1 REFERENCE 1 (residues 1 to 223) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 223) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 223) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 223) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11719. On Oct 2, 2003 this sequence version replaced NP_010142.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..223 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..223 /product="Scm3p" /calculated_mol_wt="25623" Region 92..141 /region_name="Scm3" /note="Centromere protein Scm3; pfam10384" /db_xref="CDD:463066" CDS 1..223 /gene="SCM3" /locus_tag="YDL139C" /coded_by="NM_001180199.1:1..672" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:17574026|PMID:17569568]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process [PMID:21070970]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:17548816]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:17574026|PMID:17569568]" /experiment="EXISTENCE:mutant phenotype:GO:0051382 kinetochore assembly [PMID:17569568]" /experiment="EXISTENCE:mutant phenotype:GO:0071459 protein localization to chromosome, centromeric region [PMID:17548816|PMID:17569568]" /experiment="EXISTENCE:mutant phenotype:GO:0097030 CENP-A containing nucleosome binding [PMID:21412236]" /experiment="EXISTENCE:physical interaction:GO:0000779 condensed chromosome, centromeric region [PMID:17548816]" /experiment="EXISTENCE:physical interaction:GO:0097030 CENP-A containing nucleosome binding [PMID:21412236]" /note="Non-histone component of centromeric chromatin; acts as a Cse4p specific chaperone that recognizes the centromere-targeting domain in the HFD of histone H3 variant, Cse4p, and recruits it to centromeres; involved in the assembly and maintenance of Cse4-H4 at centromeres; required for kinetochore assembly and G2/M progression; may protect Cse4p from ubiquitination; homolog of mammalian HJURP" /db_xref="GeneID:851416" /db_xref="SGD:S000002298" ORIGIN 1 mktnkkiskr rslknlhgal kgllkesgkk seskirkhsd cnpvhrvypp niekrktkkd 61 dgisrpiaer nghvyimske nhiipkltdd evmerhklad enmrkvwsni iskyesieeq 121 gdlvdlktge ivednghikt ltannstkdk rtkytsvlrd iidisdeedg dkndeytlwa 181 ndseasdsev dadndteeek deklidadfk kyeaklskri lrd // LOCUS NP_010143 763 aa linear PLN 30-JUN-2025 DEFINITION glucose sensor [Saccharomyces cerevisiae S288C]. ACCESSION NP_010143 VERSION NP_010143.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180198.1 REFERENCE 1 (residues 1 to 763) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 763) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 763) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 763) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11720. Method: conceptual translation. FEATURES Location/Qualifiers source 1..763 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..763 /product="glucose sensor" /calculated_mol_wt="83029" Region 76..555 /region_name="SP" /note="MFS transporter, sugar porter (SP) family; TIGR00879" /db_xref="CDD:273317" Site order(113,117,239,242..243,246,368..369,373..374,377..378, 403,465..466,469..470,474,497..498,501) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..763 /gene="RGT2" /locus_tag="YDL138W" /coded_by="NM_001180198.1:1..2292" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005536 D-glucose binding [PMID:29954842]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:8901598]" /experiment="EXISTENCE:mutant phenotype:GO:0010255 glucose mediated signaling pathway [PMID:9564039]" /note="Plasma membrane high glucose sensor that regulates glucose transport; low affinity sesnor that contains 12 predicted transmembrane segments and a long C-terminal tail required for hexose transporter induction; phosphorylation of the tail by Yck1p/Yck2p facilitates binding to the HXT co-repressors, Mth1p and Std1p; RGT2 has a paralog, SNF3, that arose from the whole genome duplication" /db_xref="GeneID:851417" /db_xref="SGD:S000002297" ORIGIN 1 mndsqnclrq reenshlnpg ndfghhqgae ctinhnnmph rnaytestnd teaksivmcd 61 dpnayqisyt nnepagdgai ettsillsqp lplrsnvmsv lvgifvavgg flfgydtgli 121 nsitdmpyvk tyiapnhsyf ttsqiailvs flslgtffga liapyisdsy grkptimfst 181 avifsignsl qvasgglvll ivgrvisgig igiisavvpl yqaeaaqknl rgaiissyqw 241 aitigllvss avsqgthskn gpssyripig lqyvwssila vgmiflpesp ryyvlkdeln 301 kaakslsflr glpiedprll eelveikaty dyeasfgpst lldcfktsen rpkqilrift 361 giaiqafqqa sginfifyyg vnffnntgvd nsylvsfisy avnvafsipg mylvdrigrr 421 pvllaggvim aianlviaiv gvsegktvva skimiaficl fiaafsatwg gvvwvvsael 481 yplgvrskct aicaaanwlv nftcalitpy ivdvgshtss mgpkiffiwg glnvvavivv 541 yfavyetrgl tleeidelfr kapnsvissk wnkkirkrcl afpisqqiem ktniknagkl 601 dnnnspivqd dshniidvdg flenqiqsnd hmiaadkgsg slvniidtap ltstefkpve 661 hppvnyvdlg nglglntynr gppsiisdst defyeendss yynnnterng ansvntymaq 721 linsssttsn dtsfspshns nartssnwts dlaskhsqyt spq // LOCUS NP_010144 181 aa linear PLN 30-JUN-2025 DEFINITION Arf family GTPase ARF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010144 VERSION NP_010144.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180197.1 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11721. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..181 /product="Arf family GTPase ARF2" /calculated_mol_wt="20527" Region 5..179 /region_name="ARF" /note="ARF-like small GTPases; ARF, ADP-ribosylation factor; smart00177" /db_xref="CDD:128474" Site 24..31 /site_type="other" /note="G1 box" /db_xref="CDD:206717" Site order(26..32,126..127,129,159..161) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206717" Site order(26..27,31,35,47..54,76,81) /site_type="other" /note="putative GAP interaction site [polypeptide binding]" /db_xref="CDD:206717" Site 36..51 /site_type="other" /note="Switch I region" /db_xref="CDD:206717" Site order(48..52,57,67,71,73,77,79..81) /site_type="other" /note="GEF interaction site [polypeptide binding]" /db_xref="CDD:206717" Site 48 /site_type="other" /note="G2 box" /db_xref="CDD:206717" Site order(49..51,73,80) /site_type="active" /note="effector interaction site [active]" /db_xref="CDD:206717" Site 51..66 /site_type="active" /note="interswitch region [active]" /db_xref="CDD:206717" Site 67..70 /site_type="other" /note="G3 box" /db_xref="CDD:206717" Site 69..86 /site_type="other" /note="Switch II region" /db_xref="CDD:206717" Site 126..129 /site_type="other" /note="G4 box" /db_xref="CDD:206717" Site 159..161 /site_type="other" /note="G5 box" /db_xref="CDD:206717" CDS 1..181 /gene="ARF2" /locus_tag="YDL137W" /coded_by="NM_001180197.1:1..546" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8816753]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095|PMID:20841378]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20444982]" /note="ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication; arf1 arf2 double null mutation is complemented by human ARF1, ARF4, ARF5, or ARF6" /db_xref="GeneID:851418" /db_xref="SGD:S000002296" ORIGIN 1 mglyasklfs nlfgnkemri lmvgldgagk ttvlyklklg evittiptig fnvetvqykn 61 isftvwdvgg qdrirslwrh yyrntegvif vidsndrsri gearevmqrm lnedelrnav 121 wlvfankqdl peamsaaeit eklglhsirn rpwfiqstca tsgeglyegl ewlsnnlknq 181 s // LOCUS NP_010090 120 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL29 RPL35B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010090 VERSION NP_010090.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180251.2 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11672. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..120 /product="60S ribosomal protein uL29 RPL35B" /calculated_mol_wt="13778" Region 8..60 /region_name="Ribosomal_L29" /note="Ribosomal L29 protein; pfam00831" /db_xref="CDD:459954" CDS 1..120 /gene="RPL35B" /locus_tag="YDL136W" /gene_synonym="SOS2" /coded_by="NM_001180251.2:1..363" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:20392820]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:20392820]" /note="Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication" /db_xref="GeneID:851419" /db_xref="SGD:S000002295" ORIGIN 1 magvkayelr tkskeqlasq lvdlkkelae lkvqklsrps lpkiktvrks iacvltvine 61 qqreavrqly kgkkyqpkdl rakktralrr altkfeasqv tekqrkkqia fpqrkyaika // LOCUS NP_010146 202 aa linear PLN 30-JUN-2025 DEFINITION Rdi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010146 VERSION NP_010146.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180195.1 REFERENCE 1 (residues 1 to 202) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 202) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 202) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 202) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11723. Method: conceptual translation. FEATURES Location/Qualifiers source 1..202 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..202 /product="Rdi1p" /calculated_mol_wt="23007" Region 5..202 /region_name="Rho_GDI" /note="RHO protein GDP dissociation inhibitor; pfam02115" /db_xref="CDD:460449" CDS 1..202 /gene="RDI1" /locus_tag="YDL135C" /coded_by="NM_001180195.1:1..609" /experiment="EXISTENCE:direct assay:GO:0005094 Rho GDP-dissociation inhibitor activity [PMID:10066831]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10066831|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15108020]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15108020]" /experiment="EXISTENCE:direct assay:GO:0007015 actin filament organization [PMID:9242378]" /experiment="EXISTENCE:direct assay:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:11598008]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:9242378]" /experiment="EXISTENCE:physical interaction:GO:0007266 Rho protein signal transduction [PMID:9242378]" /note="Rho GDP dissociation inhibitor; involved in the localization and regulation of Cdc42p and Rho1p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851420" /db_xref="SGD:S000002294" ORIGIN 1 maeestdfsq feeernndqy kvsakktvde yknldaedes lakwkeslgl ssdvlplefp 61 gdkrkvvvqk iqllvntepn pitfdltnek tikelaskry kikensiykl kivfkvqhei 121 itglryvqyi kkagiavdki ddhlgsyapn tktkpfyeve lpeseapsgf largnysavs 181 kfidddktnh ltlnwgveiv kk // LOCUS NP_010147 369 aa linear PLN 30-JUN-2025 DEFINITION phosphoprotein phosphatase 2A catalytic subunit PPH21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010147 VERSION NP_010147.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180193.1 REFERENCE 1 (residues 1 to 369) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 369) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 369) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 369) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11724. Method: conceptual translation. FEATURES Location/Qualifiers source 1..369 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..369 /product="phosphoprotein phosphatase 2A catalytic subunit PPH21" /EC_number="3.1.3.16" /calculated_mol_wt="41807" Region 70..352 /region_name="MPP_PP2A_PP4_PP6" /note="PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain; cd07415" /db_xref="CDD:277360" Site order(111,127,130..131,133..134,136,138..139,151,166..170, 181..182,185..186,190..191,194..195,203,328,337,347) /site_type="other" /note="heterotrimer interface [polypeptide binding]" /db_xref="CDD:277360" Site order(117,119,145,149,177..178,182..183,187,227,249..251, 260,273..275,301,303,327..329) /site_type="active" /db_xref="CDD:277360" Site order(117,119,145,177,227,301) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277360" CDS 1..369 /gene="PPH21" /locus_tag="YDL134C" /coded_by="NM_001180193.1:1..1110" /experiment="EXISTENCE:direct assay:GO:0000159 protein phosphatase type 2A complex [PMID:17550305]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12518319]" /experiment="EXISTENCE:genetic interaction:GO:1903432 regulation of TORC1 signaling [PMID:12820961]" /experiment="EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:27973551]" /experiment="EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:2176150]" /experiment="EXISTENCE:physical interaction:GO:0006417 regulation of translation [PMID:10329624]" /note="Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph22p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication" /db_xref="GeneID:851421" /db_xref="SGD:S000002292" ORIGIN 1 mdtdldvpmq davteqltpt vsedmdlnnn ssdnnaeefs vddlkpgssg iadhksskpl 61 elnntninql dqwiehlskc eplseddvar lckmavdvlq feenvkpinv pvticgdvhg 121 qfhdllelfk iggpcpdtny lfmgdyvdrg yysvetvsyl vamkvryphr itilrgnhes 181 rqitqvygfy declrkygsa nvwkmftdlf dyfpitalvd nkifclhggl spmietidqv 241 relnriqevp hegpmcdllw sdpddrggwg isprgagftf gqdvseqfnh tndlsliara 301 hqlvmegyaw shqqnvvtif sapnycyrcg nqaaimevde nhnrqflqyd psvrpgepsv 361 srktpdyfl // LOCUS NP_010148 25 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL41 RPL41B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010148 VERSION NP_010148.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180194.1 REFERENCE 1 (residues 1 to 25) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 25) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 25) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 25) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11725. Method: conceptual translation. FEATURES Location/Qualifiers source 1..25 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..25 /product="60S ribosomal protein eL41 RPL41B" /calculated_mol_wt="3206" CDS 1..25 /gene="RPL41B" /locus_tag="YDL133C-A" /gene_synonym="RPL47B; YDL134C-A" /coded_by="NM_001180194.1:1..78" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication" /db_xref="GeneID:851422" /db_xref="SGD:S000002293" ORIGIN 1 mrakwrkkrt rrlkrkrrkv rarsk // LOCUS NP_010149 437 aa linear PLN 30-JUN-2025 DEFINITION phospholipase D regulator [Saccharomyces cerevisiae S288C]. ACCESSION NP_010149 VERSION NP_010149.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180192.1 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11726. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..437 /product="phospholipase D regulator" /calculated_mol_wt="49449" CDS 1..437 /gene="SRF1" /locus_tag="YDL133W" /coded_by="NM_001180192.1:1..1314" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0043085 positive regulation of catalytic activity [PMID:21347278]" /note="Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients" /db_xref="GeneID:851423" /db_xref="SGD:S000002291" ORIGIN 1 mgdsnssqea ysdttstnas riadqnqlnl nvdleknqtv rksgslealq nakihvpkhs 61 dgspldypkl ntytfvpttv ppyvleaqfd klrlqdkgtv dgnvtddknl pkefkwgqfa 121 stigchsayt rdqnynpshk sydgyslsss tssknaalre ilgdmcsewg geerlegvlh 181 seiganlefn tteerkewlq yiekvkdfyy gdnkknpesp esvhnkvyks dwvnelnker 241 ekwrrlkqrk lqqwrpplts llldnqylil glriftgils cislalaiki fqnsrsnnti 301 seskigqqps timaicvnav aiayiiyiah defagkpvgl rnplsklkli lldllfiifs 361 sanlalafnt rfdkewvcts irrsngstyg ypkipricrk qealsaflfv alfmwvitfs 421 isivrvvekv ssitnrn // LOCUS NP_010150 815 aa linear PLN 30-JUN-2025 DEFINITION cullin CDC53 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010150 VERSION NP_010150.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180191.1 REFERENCE 1 (residues 1 to 815) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 815) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 815) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 815) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 815) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 815) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 815) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 815) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 815) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11727. Method: conceptual translation. FEATURES Location/Qualifiers source 1..815 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..815 /product="cullin CDC53" /calculated_mol_wt="93813" Region 7..815 /region_name="COG5647" /note="Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]" /db_xref="CDD:227934" CDS 1..815 /gene="CDC53" /locus_tag="YDL132W" /coded_by="NM_001180191.1:1..2448" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16421250]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:9346239|PMID:10385629]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9346239|PMID:9346238]" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:19882662|PMID:9346239|PMID:9346238]" /experiment="EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:9346238|PMID:9346239]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:9346238]" /experiment="EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:9736614|PMID:7954792]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8943317]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:9499404]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:9346238|PMID:9346239]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:9499404]" /note="Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant" /db_xref="GeneID:851424" /db_xref="SGD:S000002290" ORIGIN 1 msetlprsdd leatwnfiep ginqilgnek nqastskrvy kilsptmyme vytaiynycv 61 nksrssghfs tdsrtgqsti lvgseiyekl knylknyiln fkqsnsetfl qfyvkrwkrf 121 tigaiflnha fdymnrywvq kersdgkrhi fdvntlclmt wkevmfdpsk dvlinelldq 181 vtlgregqii qrsnistaik slvalgidpq dlkklnlnvy iqvfekpflk ktqeyytqyt 241 ndylekhsvt eyifeaheii kreekamtiy wddhtkkpls malnkvlitd hieklenefv 301 vlldardiek itslyalirr dftliprmas vfenyvkktg eneissllam hkhnimknen 361 anpkklalmt ahslspkdyi kkllevhdif skifnesfpd diplakaldn acgafinine 421 falpagspks atsktsemla kysdillkka tkpevasdms dediitifky ltdkdafeth 481 yrrlfakrli hgtstsaede eniiqrlqaa nsmeytgkit kmfqdirlsk ileddfaval 541 knepdyskak ypdlqpfvla enmwpfsyqe vefklpkelv psheklkesy sqkhngrilk 601 wlwplcrgel kadigkpgrm pfnftvtlfq mailllynda dvltleniqe gtsltiqhia 661 aamvpfikfk liqqvppgld alvkpetqfk lsrpykalkt ninfasgvkn dilqslsggg 721 hdnhgnklgn krltederie kelnterqif leacivrimk akrnlphttl vneciaqshq 781 rfnakvsmvk raidsliqkg ylqrgddges yayla // LOCUS NP_010151 440 aa linear PLN 30-JUN-2025 DEFINITION homocitrate synthase LYS21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010151 VERSION NP_010151.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180190.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11728. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..440 /product="homocitrate synthase LYS21" /EC_number="2.3.3.14" /calculated_mol_wt="48463" Region 37..298 /region_name="DRE_TIM_HCS" /note="Saccharomyces cerevisiae homocitrate synthase and related proteins, catalytic TIM barrel domain; cd07948" /db_xref="CDD:163685" Site order(45..46,49,76,105,107,169,197,226,228) /site_type="active" /db_xref="CDD:163685" Site order(45..46,76) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:163685" Site order(46,197,226,228) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:163685" CDS 1..440 /gene="LYS21" /locus_tag="YDL131W" /coded_by="NM_001180190.1:1..1323" /experiment="EXISTENCE:direct assay:GO:0004410 homocitrate synthase activity [PMID:10103047]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9099739|PMID:11914276]" /experiment="EXISTENCE:genetic interaction:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:18524920]" /experiment="EXISTENCE:mutant phenotype:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:18524920]" /note="Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS21 has a paralog, LYS20, that arose from the whole genome duplication" /db_xref="GeneID:851425" /db_xref="SGD:S000002289" ORIGIN 1 msennefqsv testtaptts npygpnpady lsnvknfqli dstlregeqf anaffdtekk 61 ieiaralddf gvdyieltsp vaseqsrkdc eaicklglka kilthirchm ddarvavetg 121 vdgvdvvigt skflrqyshg kdmnyiaksa veviefvksk gieirfssed sfrsdlvdll 181 niyktvdkig vnrvgiadtv gcanprqvye lirtlksvvs cdiechfhnd tgcaianayt 241 aleggarlid vsvlgigern gitplgglma rmivaapdyv rskyklhkir dienlvadav 301 evnipfnnpi tgfcafthka gihakailan pstyeildph dfgmkryihf anrltgwnai 361 ksrvdqlnln ltddqikevt akikklgdvr plniddvdsi ikdfhaelst pllkpvnkgt 421 dddnidisng hvskkakvtk // LOCUS NP_010152 86 aa linear PLN 30-JUN-2025 DEFINITION ATPase-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010152 VERSION NP_010152.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184325.1 REFERENCE 1 (residues 1 to 86) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 86) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 86) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 86) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11729. Method: conceptual translation. FEATURES Location/Qualifiers source 1..86 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..86 /product="ATPase-binding protein" /calculated_mol_wt="9931" Region <24..86 /region_name="IATP" /note="Mitochondrial ATPase inhibitor, IATP; pfam04568" /db_xref="CDD:428014" CDS 1..86 /gene="STF1" /locus_tag="YDL130W-A" /gene_synonym="AIS2" /coded_by="NM_001184325.1:1..261" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:12167646|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0032780 negative regulation of ATP-dependent activity [PMID:12809520]" /experiment="EXISTENCE:direct assay:GO:0051117 ATPase binding [PMID:2172220]" /note="Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p act as stabilizing factors that enhance inhibitory action of the Inh1p protein; protein abundance increases in response to DNA replication stress; STF1 has a paralog, INH1, that arose from the whole genome duplication" /db_xref="GeneID:851426" /db_xref="SGD:S000007232" ORIGIN 1 mlnrcisrnt rlpvnlrias rfysdgplgg agpgnpqdif ikrerakedy yarqqereql 61 ahvkeqlkeh kkklenlenk innlsk // LOCUS NP_010153 106 aa linear PLN 30-JUN-2025 DEFINITION ribosomal protein P1 RPP1B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010153 VERSION NP_010153.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180189.1 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11730. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..106 /product="ribosomal protein P1 RPP1B" /calculated_mol_wt="10536" Region 3..105 /region_name="Ribosomal_P1" /note="Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins...; cd05831" /db_xref="CDD:100109" CDS 1..106 /gene="RPP1B" /locus_tag="YDL130W" /gene_synonym="RPL44'; RPLA3" /coded_by="NM_001180189.1:1..321" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:1601875]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:1601875]" /note="Ribosomal protein P1 beta; component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; free (non-ribosomal) P1 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; accumulation is regulated by phosphorylation and interaction with the P2 stalk component" /db_xref="GeneID:851427" /db_xref="SGD:S000002288" ORIGIN 1 msdsiisfaa filadaglei tsdnlltitk aaganvdnvw advyakaleg kdlkeilsgf 61 hnagpvagag aasgaaaagg daaaeeekee eaaeesdddm gfglfd // LOCUS NP_010154 291 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL129W [Saccharomyces cerevisiae S288C]. ACCESSION NP_010154 VERSION NP_010154.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180188.1 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11731. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..291 /product="uncharacterized protein" /calculated_mol_wt="32785" CDS 1..291 /locus_tag="YDL129W" /coded_by="NM_001180188.1:1..876" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:11914276|PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:851428" /db_xref="SGD:S000002287" ORIGIN 1 melrsrrsae aylvtpeepa knksersies nervgtreak sentsvfspa ysdtattdss 61 kkvddneyyn ftshfmpslk ntrelentil nliqrikegd detlvsekdl ilsvlnrsla 121 stshwklqaq lselratseg ryavetnllk keveflknkt pktnesassa elrpllerpl 181 krklslpgla qrplstgarl eggyggvspn swktkvpklp lpasrpslnl spqkvptgtd 241 kveedtkidt lelvennkph prmrrrsdnp atneyvrvfh lekkepksrk k // LOCUS NP_010155 411 aa linear PLN 30-JUN-2025 DEFINITION Vcx1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010155 VERSION NP_010155.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180187.1 REFERENCE 1 (residues 1 to 411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 411) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11732. Method: conceptual translation. FEATURES Location/Qualifiers source 1..411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..411 /product="Vcx1p" /calculated_mol_wt="44515" Region 43..396 /region_name="cax" /note="calcium/proton exchanger (cax); TIGR00378" /db_xref="CDD:273043" CDS 1..411 /gene="VCX1" /locus_tag="YDL128W" /gene_synonym="HUM1; MNR1" /coded_by="NM_001180187.1:1..1236" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:8628289]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20709757|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006816 calcium ion transport [PMID:8628289]" /experiment="EXISTENCE:direct assay:GO:0015369 calcium:proton antiporter activity [PMID:8628289]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:8628289]" /experiment="EXISTENCE:mutant phenotype:GO:0006816 calcium ion transport [PMID:8628289]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:8628289]" /experiment="EXISTENCE:mutant phenotype:GO:0015369 calcium:proton antiporter activity [PMID:8628289|PMID:20709757]" /experiment="EXISTENCE:mutant phenotype:GO:0015386 potassium:proton antiporter activity [PMID:20709757]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:8628289]" /note="Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter" /db_xref="GeneID:851429" /db_xref="SGD:S000002286" ORIGIN 1 mdattplltv anshparnpk htawraavyd lqyilkaspl nfllvfvplg liwghfqlsh 61 tltflfnfla iiplaailan ateeladkag ntiggllnat fgnavelivs iialkkgqvr 121 ivqasmlgsl lsnlllvlgl cfifggynrv qqtfnqtaaq tmssllaiac asllipaafr 181 atlphgkedh fidgkilels rgtsiviliv yvlflyfqlg shhalfeqqe eetdevmsti 241 srnphhslsv ksslvillgt tviisfcadf lvgtidnvve stglsktfig livipivgna 301 aehvtsvlva mkdkmdlalg vaigsslqva lfvtpfmvlv gwmidvpmtl nfstfetatl 361 fiavflsnyl ildgesnwle gvmslamyil iamaffyypd ektldsigns l // LOCUS NP_010156 308 aa linear PLN 30-JUN-2025 DEFINITION cyclin PCL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010156 VERSION NP_010156.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180186.1 REFERENCE 1 (residues 1 to 308) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 308) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 308) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 308) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11733. On Feb 23, 2004 this sequence version replaced NP_010156.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..308 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..308 /product="cyclin PCL2" /calculated_mol_wt="35076" Region 48..143 /region_name="CYCLIN_ScPCL1-like" /note="cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; cd20557" /db_xref="CDD:410260" Site order(65,105,113..115,131,134..135) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410260" CDS 1..308 /gene="PCL2" /locus_tag="YDL127W" /gene_synonym="CLN4" /coded_by="NM_001180186.1:1..927" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:14688790]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14688790]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:14688790]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14688790]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7973731]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:19458192]" /experiment="EXISTENCE:genetic interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:7973731]" /experiment="EXISTENCE:physical interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]" /note="Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth; PCL2 has a paralog, PCL9, that arose from the whole genome duplication" /db_xref="GeneID:851430" /db_xref="SGD:S000002285" ORIGIN 1 msnyeallkf nrkavskemv qylasttasi ikikktnsmi dialpapplt kfinrlikhs 61 nvqtptlmat svylaklrsi ipsnvygiet trhriflgcl ilaaktlnds splnkhwaey 121 tdgllilrev ntierelley fdwdvtistd dlitclspfl kpikeeqlyk sqrdcrtlkn 181 fsaqekdivn ktsishsrss snmsipslas tstlstlesr rsnlsnysnr irtlpelhes 241 nnisdkfspr tynidskhdn kenrpiptik pfnfskarpv ilktglnkqi ikedtkvkks 301 nwsnyfks // LOCUS NP_010157 835 aa linear PLN 30-JUN-2025 DEFINITION AAA family ATPase CDC48 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010157 VERSION NP_010157.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180185.1 REFERENCE 1 (residues 1 to 835) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 835) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 835) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 835) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11734. Method: conceptual translation. FEATURES Location/Qualifiers source 1..835 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..835 /product="AAA family ATPase CDC48" /EC_number="3.6.4.6" /calculated_mol_wt="91865" Region 48..785 /region_name="CDC48" /note="AAA family ATPase, CDC48 subfamily; TIGR01243" /db_xref="CDD:273521" CDS 1..835 /gene="CDC48" /locus_tag="YDL126C" /coded_by="NM_001180185.1:1..2508" /experiment="EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873065|PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:9436996]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:15910746]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15910746|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006274 DNA replication termination [PMID:31509741]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:7492595]" /experiment="EXISTENCE:direct assay:GO:0030894 replisome [PMID:31509741]" /experiment="EXISTENCE:direct assay:GO:0030970 retrograde protein transport, ER to cytosol [PMID:32588820]" /experiment="EXISTENCE:direct assay:GO:0031593 polyubiquitin modification-dependent protein binding [PMID:27129255]" /experiment="EXISTENCE:direct assay:GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex [PMID:11598205|PMID:11733065]" /experiment="EXISTENCE:direct assay:GO:0036266 Cdc48p-Npl4p-Vms1p AAA ATPase complex [PMID:21070972]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:11733065]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:1990112 RQC complex [PMID:23178123]" /experiment="EXISTENCE:direct assay:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:27129255]" /experiment="EXISTENCE:genetic interaction:GO:0032984 protein-containing complex disassembly [PMID:26255844]" /experiment="EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:29444958]" /experiment="EXISTENCE:mutant phenotype:GO:0010636 positive regulation of mitochondrial fusion [PMID:29309037]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20855502]" /experiment="EXISTENCE:mutant phenotype:GO:0016320 endoplasmic reticulum membrane fusion [PMID:7553849]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:23418575]" /experiment="EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:32588820|PMID:11740563]" /experiment="EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:20483956]" /experiment="EXISTENCE:mutant phenotype:GO:0032984 protein-containing complex disassembly [PMID:25342810|PMID:26255844]" /experiment="EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:20508643]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:20855502]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11739805|PMID:11813000|PMID:11756557|PMID:11740563]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:20206597|PMID:29309037]" /experiment="EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:29444958]" /experiment="EXISTENCE:mutant phenotype:GO:0051228 mitotic spindle disassembly [PMID:14636562]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:22505030]" /experiment="EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:18812321]" /experiment="EXISTENCE:mutant phenotype:GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system [PMID:22718752]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:21070972|PMID:32118579]" /experiment="EXISTENCE:mutant phenotype:GO:0099638 endosome to plasma membrane protein transport [PMID:36125415]" /experiment="EXISTENCE:mutant phenotype:GO:0120174 stress-induced homeostatically regulated protein degradation pathway [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:0140624 EGAD pathway [PMID:31368600]" /experiment="EXISTENCE:mutant phenotype:GO:1900182 positive regulation of protein localization to nucleus [PMID:11733065|PMID:11598205]" /experiment="EXISTENCE:mutant phenotype:GO:1902979 mitotic DNA replication termination [PMID:25342810]" /experiment="EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23479637|PMID:23358411]" /experiment="EXISTENCE:mutant phenotype:GO:1990171 SCF complex disassembly in response to cadmium stress [PMID:23000173]" /experiment="EXISTENCE:physical interaction:GO:1990112 RQC complex [PMID:23479637]" /note="AAA ATPase with protein-unfoldase activity; subunit of polyUb-selective segregase complex involved in ERAD, EGAD, INM-associated degradation (INMAD), mitotic spindle disassembly, macroautophagy, PMN, ribosome-associated degradation, ribophagy, homotypic ER membrane fusion, SCF complex disassembly, cell wall integrity, and telomerase regulation; mobilizes membrane-anchored transcription factors by regulated Ub/proteasome-dependent processing (RUP); human ortholog VCP complements a cdc48 mutant" /db_xref="GeneID:851431" /db_xref="SGD:S000002284" ORIGIN 1 mgeehkplld asgvdpreed ktatailrrk kkdnmllvdd ainddnsvia insntmdkle 61 lfrgdtvlvk gkkrkdtvli vliddeledg acrinrvvrn nlrirlgdlv tihpcpdiky 121 atrisvlpia dtiegitgnl fdvflkpyfv eayrpvrkgd hfvvrggmrq vefkvvdvep 181 eeyavvaqdt iihwegepin redeennmne vgyddiggcr kqmaqiremv elplrhpqlf 241 kaigikpprg vlmygppgtg ktlmaravan etgaffflin gpevmskmag esesnlrkaf 301 eeaeknapai ifideidsia pkrdktngev errvvsqllt lmdgmkarsn vvviaatnrp 361 nsidpalrrf grfdrevdig ipdatgrlev lrihtknmkl addvdleala aethgyvgad 421 iaslcseaam qqirekmdli dldedeidae vldslgvtmd nfrfalgnsn psalretvve 481 svnvtwddvg gldeikeelk etveypvlhp dqytkfglsp skgvlfygpp gtgktllaka 541 vatevsanfi svkgpellsm wygesesnir difdkaraaa ptvvfldeld siakarggsl 601 gdaggasdrv vnqlltemdg mnakknvfvi gatnrpdqid pailrpgrld qliyvplpde 661 narlsilnaq lrktplepgl eltaiakatq gfsgadllyi vqraakyaik dsieahrqhe 721 aekevkvege dvemtdegak aeqepevdpv pyitkehfae amktakrsvs daelrryeay 781 sqqmkasrgq fsnfnfndap lgttatdnan snnsapsgag aafgsnaeed ddlys // LOCUS NP_010158 158 aa linear PLN 30-JUN-2025 DEFINITION adenosine 5'-monophosphoramidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010158 VERSION NP_010158.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180184.1 REFERENCE 1 (residues 1 to 158) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 158) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 158) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 158) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11735. Method: conceptual translation. FEATURES Location/Qualifiers source 1..158 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..158 /product="adenosine 5'-monophosphoramidase" /calculated_mol_wt="17548" Region 25..122 /region_name="HINT_subgroup" /note="HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; cd01277" /db_xref="CDD:238608" Site order(114,116,118..120) /site_type="active" /note="HIT family signature motif [active]" /db_xref="CDD:238608" Site 116 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:238608" CDS 1..158 /gene="HNT1" /locus_tag="YDL125C" /coded_by="NM_001180184.1:1..477" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0009117 nucleotide metabolic process [PMID:11805111]" /experiment="EXISTENCE:direct assay:GO:0043530 adenosine 5'-monophosphoramidase activity [PMID:11805111]" /note="Adenosine 5'-monophosphoramidase; interacts physically and genetically with CDK and TFIIK subunit Kin28p, and genetically with CAK1; member of histidine triad (HIT) superfamily of nucleotide-binding proteins; protein abundance increases in response to DNA replication stress; human homolog HINT1 can complement yeast hnt1 mutant" /db_xref="GeneID:851432" /db_xref="SGD:S000002283" ORIGIN 1 meplisapyl tttkmsapat ldaacifcki ikseipsfkl ietkysyafl diqptaegha 61 liipkyhgak lhdipdeflt dampiakrla kamkldtynv lqnngkiahq evdhvhfhli 121 pkrdeksgli vgwpaqetdf dklgklhkel laklegsd // LOCUS NP_010159 312 aa linear PLN 30-JUN-2025 DEFINITION aldo-keto reductase superfamily protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010159 VERSION NP_010159.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180183.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11736. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..312 /product="aldo-keto reductase superfamily protein" /calculated_mol_wt="35430" Region 13..291 /region_name="AKR_AKR3C2-3" /note="Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; cd19120" /db_xref="CDD:381346" Site order(23..27,59,64,89,122..123,157..158,179,207..210, 213..214,256..259,261,264) /site_type="active" /db_xref="CDD:381346" Site order(59,64,89,122) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381346" CDS 1..312 /locus_tag="YDL124W" /coded_by="NM_001180183.1:1..939" /experiment="EXISTENCE:direct assay:GO:0004032 aldose reductase (NADPH) activity [PMID:11306085]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0008106 alcohol dehydrogenase (NADP+) activity [PMID:17140678]" /experiment="EXISTENCE:direct assay:GO:0042180 ketone metabolic process [PMID:17140678]" /experiment="EXISTENCE:direct assay:GO:0051268 alpha-keto amide reductase activity [PMID:15564669]" /experiment="EXISTENCE:direct assay:GO:0051269 alpha-ketoester reductase (NADPH) activity [PMID:15564669]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:17919749]" /note="NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851433" /db_xref="SGD:S000002282" ORIGIN 1 msfhqqfftl nngnkipaia iigtgtrwyk neetdatfsn slveqivyal klpgiihida 61 aeiyrtypev gkalsltekp rnaifltdky spqikmsdsp adgldlalkk mgtdyvdlyl 121 lhspfvskev nglsleeawk dmeqlyksgk aknigvsnfa vedlqrilkv aevkpqvnqi 181 efspflqnqt pgiykfcqeh dilveayspl gplqkktaqd dsqpffeyvk elsekyikse 241 aqiilrwvtk rgvlpvttss kpqrisdaqn lfsfdltaee vdkitelgle heplrlywnk 301 lygkynyaaq kv // LOCUS NP_010160 140 aa linear PLN 30-JUN-2025 DEFINITION Sna4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010160 VERSION NP_010160.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180182.1 REFERENCE 1 (residues 1 to 140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 140) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11737. Method: conceptual translation. FEATURES Location/Qualifiers source 1..140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..140 /product="Sna4p" /calculated_mol_wt="15542" Region 12..60 /region_name="Pmp3" /note="Proteolipid membrane potential modulator; pfam01679" /db_xref="CDD:460290" CDS 1..140 /gene="SNA4" /locus_tag="YDL123W" /coded_by="NM_001180182.1:1..423" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:19168755]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:11566881]" /experiment="EXISTENCE:mutant phenotype:GO:0000328 fungal-type vacuole lumen [PMID:19168755]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:19168755]" /note="hypothetical protein; localized to the vacuolar outer membrane; predicted to be palmitoylated" /db_xref="GeneID:851434" /db_xref="SGD:S000002281" ORIGIN 1 mccycvcctv sdfilyivaf ffppaavllr sgpcssdfll nvlltllgfl pgmlhafyyi 61 titsplrnae yvyyyqqgwv dsernvpsnr pqnsqtpqnr pqqgssarnv ypsvetpllq 121 gaaphdnkqs lvespppyvp // LOCUS NP_010161 809 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease UBP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010161 VERSION NP_010161.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180181.1 REFERENCE 1 (residues 1 to 809) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 809) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 809) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 809) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11738. Method: conceptual translation. FEATURES Location/Qualifiers source 1..809 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..809 /product="ubiquitin-specific protease UBP1" /EC_number="3.4.19.12" /calculated_mol_wt="92638" Region 101..>293 /region_name="Peptidase_C19" /note="Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cl02553" /db_xref="CDD:470612" Region 102..736 /region_name="Peptidase_C19F" /note="A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02662" /db_xref="CDD:239127" Site order(105,110,697,713) /site_type="active" /db_xref="CDD:239127" Region <427..>510 /region_name="Peptidase_C19" /note="Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cl02553" /db_xref="CDD:470612" CDS 1..809 /gene="UBP1" /locus_tag="YDL122W" /coded_by="NM_001180181.1:1..2430" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:1429680]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15635103]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15635103|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:31713515]" /experiment="EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:2050695|PMID:1429680]" /note="Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains" /db_xref="GeneID:851435" /db_xref="SGD:S000002280" ORIGIN 1 mdlfieskin sllqflfgsr qdflrnfktw snnnnnlsiy llifgivvff ykkpdhlnyi 61 vesvsemttn frnnnslsrw lprskfthld eeilkrggfi aglvndgntc fmnsvlqsla 121 ssrelmefld nnvirtyeei eqnehneegn gqesaqdeat hkkntrkggk vygkhkkkln 181 rkssskedee ksqepditfs valrdllsal nakyyrdkpy fktnsllkam sksprknill 241 gydqedaqef fqnilaeles nvkslntekl dttpvaksel pddalvgqln lgevgtvyip 301 teqidpnsil hdksiqnftp fklmtpldgi taerigclqc genggirysv fsglslnlpn 361 enigstlkls qllsdwskpe iiegvecnrc altaahshlf gqlkefekkp egsipeklin 421 avkdrvhqie evlakpvidd edykklhtan mvrkcskskq ilisrpppll sihinrsvfd 481 prtymirknn skvlfksrln lapwccdine inldarlpms kkekaaqqds sedeniggey 541 ytklherfeq efedseeeke yddaegnyas hynhtkdisn ydplngevdg vtsddedeyi 601 eetdalgnti kkriiehsdv enenvkdnee lqeidnvsld epkinvedql etssdeedvi 661 pappinyars fstvpatplt yslrsvivhy gthnyghyia frkyrgcwwr isdetvyvvd 721 eaevlstpgv fmlfyeydfd eetgkmkddl eaiqsnneed dekeqeqkgv qepkesqeqg 781 egeeqeegqe qmkfertedh rdisgkdvn // LOCUS NP_010162 149 aa linear PLN 30-JUN-2025 DEFINITION Exp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010162 VERSION NP_010162.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180180.1 REFERENCE 1 (residues 1 to 149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 149) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11739. Method: conceptual translation. FEATURES Location/Qualifiers source 1..149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..149 /product="Exp1p" /calculated_mol_wt="16816" CDS 1..149 /gene="EXP1" /locus_tag="YDL121C" /coded_by="NM_001180180.1:1..450" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10684247|PMID:14562095|PMID:26928762]" /note="A cargo receptor protein for Pma1p; works with Psg1p to promote the transport and maturation of Pma1p; localizes to the ER and COPII vesicles; a non-essential protein" /db_xref="GeneID:851436" /db_xref="SGD:S000002279" ORIGIN 1 mnlygyflll iiviafiall plfsgigtfk ltkpkssata qsatgklgkr eylkkkldht 61 nvlkfdlkdt eeslghdsas assasrkfei dsktglkrrv igqynkdpnd fdfdiddlin 121 edelderree ekklkkyngk kneayegfv // LOCUS NP_010163 174 aa linear PLN 30-JUN-2025 DEFINITION ferroxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010163 VERSION NP_010163.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180179.1 REFERENCE 1 (residues 1 to 174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 174) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11740. Method: conceptual translation. FEATURES Location/Qualifiers source 1..174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..174 /product="ferroxidase" /EC_number="1.16.3.1" /calculated_mol_wt="19359" Region 72..168 /region_name="mito_frataxin" /note="frataxin; TIGR03422" /db_xref="CDD:132463" Site order(78..79,82,86,89..90,99,101) /site_type="other" /note="putative iron binding site [ion binding]" /db_xref="CDD:238280" CDS 1..174 /gene="YFH1" /locus_tag="YDL120W" /coded_by="NM_001180179.1:1..525" /experiment="EXISTENCE:direct assay:GO:0004322 ferroxidase activity [PMID:12732649|PMID:12149269]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:9241271|PMID:9180083|PMID:24769239|PMI D:14576278]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10428860]" /experiment="EXISTENCE:direct assay:GO:0006879 intracellular iron ion homeostasis [PMID:9180083]" /experiment="EXISTENCE:direct assay:GO:0008198 ferrous iron binding [PMID:10930361|PMID:16784228]" /experiment="EXISTENCE:direct assay:GO:0016226 iron-sulfur cluster assembly [PMID:12947415]" /experiment="EXISTENCE:direct assay:GO:0034986 iron chaperone activity [PMID:12732649]" /experiment="EXISTENCE:genetic interaction:GO:0006879 intracellular iron ion homeostasis [PMID:9180083|PMID:11734220]" /experiment="EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:14741370]" /experiment="EXISTENCE:genetic interaction:GO:0034986 iron chaperone activity [PMID:15247478]" /experiment="EXISTENCE:mutant phenotype:GO:0006749 glutathione metabolic process [PMID:18562474]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9180083|PMID:11734220]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:12947415|PMID:12970193|PMID:12221295]" /experiment="EXISTENCE:physical interaction:GO:0016226 iron-sulfur cluster assembly [PMID:14741370]" /note="Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog FXN is mutated in Friedrich's ataxia; human FTL gene can complement yeast yfh1 null mutant" /db_xref="GeneID:851437" /db_xref="SGD:S000002278" ORIGIN 1 mikrslaslv rvssvmgrry miaaaggera rfcpavtnkk nhtvntfqkr fvesstdgqv 61 vpqevlnlpl ekyheeaddy ldhlldslee lseahpdcip dvelshgvmt leipafgtyv 121 inkqppnkqi wlasplsgpn rfdllngewv slrngtkltd ilteevekai sksq // LOCUS NP_010164 307 aa linear PLN 30-JUN-2025 DEFINITION Hem25p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010164 VERSION NP_010164.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180178.1 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11741. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..307 /product="Hem25p" /calculated_mol_wt="34073" Region 12..92 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 114..200 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 229..307 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..307 /gene="HEM25" /locus_tag="YDL119C" /coded_by="NM_001180178.1:1..924" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:27476175|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015187 glycine transmembrane transporter activity [PMID:27476175]" /experiment="EXISTENCE:genetic interaction:GO:0006783 heme biosynthetic process [PMID:26821380]" /experiment="EXISTENCE:genetic interaction:GO:0015187 glycine transmembrane transporter activity [PMID:26821380]" /experiment="EXISTENCE:genetic interaction:GO:1904983 glycine import into mitochondrion [PMID:26821380]" /experiment="EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:26821380|PMID:27476175]" /experiment="EXISTENCE:mutant phenotype:GO:0015187 glycine transmembrane transporter activity [PMID:26821380|PMID:27476175]" /experiment="EXISTENCE:mutant phenotype:GO:1904983 glycine import into mitochondrion [PMID:26821380|PMID:27476175]" /note="Mitochondrial glycine transporter; required for the transport of glycine into mitochondria for initiation of heme biosynthesis, with YMC1 acting as a secondary transporter; homolog of human SLC25A38, a mitochondrial glycine transporter associated with nonsyndromic autosomal recessive congenital sideroblastic anemia; human SLC25A38 can complement the heme deficiency associated with the null mutant; GFP-fusion protein is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:851439" /db_xref="SGD:S000002277" ORIGIN 1 mteqatkprn sshliggffg gltsavalqp ldllktriqq dkkatlwknl keidsplqlw 61 rgtlpsalrt sigsalylsc lnlmrsslak rrnavpsltn dsnivynkss slprltmyen 121 lltgafargl vgyitmpitv ikvryestly nysslkeait hiytkeglfg ffrgfgatcl 181 rdapyaglyv llyekskqll pmvlpsrfih ynpeggftty tsttvnttsa vlsaslattv 241 tapfdtiktr mqlepskftn sfntftsivk nenvlklfsg lsmrlarkaf sagiawgiye 301 elvkrfm // LOCUS NP_010166 885 aa linear PLN 30-JUN-2025 DEFINITION Cyk3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010166 VERSION NP_010166.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180176.1 REFERENCE 1 (residues 1 to 885) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 885) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 885) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 885) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11743. Method: conceptual translation. FEATURES Location/Qualifiers source 1..885 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..885 /product="Cyk3p" /calculated_mol_wt="100490" Region 13..65 /region_name="SH3" /note="Src Homology 3 domain superfamily; cl17036" /db_xref="CDD:473055" Site order(18,20,23,27,44..45,61,63..64) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212690" Region 415..618 /region_name="CYK3" /note="Cytokinesis protein 3, contains TGc (transglutaminase/protease-like) domain [Cell cycle control, cell division, chromosome partitioning]; COG5279" /db_xref="CDD:444090" Region 516..578 /region_name="TGc" /note="Transglutaminase/protease-like homologues; smart00460" /db_xref="CDD:214673" CDS 1..885 /gene="CYK3" /locus_tag="YDL117W" /coded_by="NM_001180176.1:1..2658" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:21498574]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:21498574|PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:22956544]" /experiment="EXISTENCE:genetic interaction:GO:1990344 secondary cell septum biogenesis [PMID:19528296]" /experiment="EXISTENCE:physical interaction:GO:0044697 HICS complex [PMID:22623719]" /experiment="EXISTENCE:physical interaction:GO:1990344 secondary cell septum biogenesis [PMID:19528296]" /note="SH3-domain protein located in the bud neck and cytokinetic actin ring; relocalizes from bud neck to nucleus upon DNA replication stress; activates the chitin synthase activity of Chs2p during cytokinesis; suppressor of growth and cytokinesis defects of chs2 phospho-mutants" /db_xref="GeneID:851440" /db_xref="SGD:S000002275" ORIGIN 1 matnltslkp pfkvkarygw sgqtkgdlgf legdimevtr iagswfygkl lrnkkcsgyf 61 phnfvillee rlnsstengr qpskivesfe ksnkvvippv psrysderpr pkkklsssmp 121 nspkkpvdsl tkarkakske mvnekniynt qssrhhnnsa pnlplashsk pqvrnfeesm 181 nnplpplppl pdldnmrktd krapkksysa ndlhmarssr eynyykdnqk fydgfipekr 241 ysleedsiss glfsnsqyln dsacssensf almsdfsats agsfarhkya qsfsdslqrs 301 qnangcstki ndsqefgdsn assrngkmgd ilrkiiipkr ntniysssvs spkspkaypk 361 lpdiqnlnls atpdeardwi avkchlnrar tltkydkhpr ymraleenrd lilhpqdsiy 421 nglntnevkg ntkpglvdve laelnieyid kmtwkrcird gtmtldswaq ttfsarystv 481 leklrgiyif ctemfaltdd ngtsdfsaep qnlekilyrk hctpyeltwl fkklanslgi 541 tceivigflk tpsainwefk ynhcwlrilv nkewrfidvi lgnvtnpihe fvnnrkikka 601 ensyflmapl emiythippr efeqhivpsi dqlsalylpl vfpsffknel klykfstals 661 fledseiyec sleipndvev fasvviptdn eeassayrnm elaltqikkq kaesgrrial 721 ikavlppnvn kgslyihsgv rgtqtsiani hplsmmvplt hkgsnmkyef vikipsesiq 781 kielyivepq srylfvgney sfeviqspsd givyssdegp nqnrkqpmai kspsgrvhel 841 vksdphfpyg twkgsikike pgvwsalvia dsgigwsvfa ewlcv // LOCUS NP_010167 726 aa linear PLN 30-JUN-2025 DEFINITION Nup84p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010167 VERSION NP_010167.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180175.1 REFERENCE 1 (residues 1 to 726) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 726) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 726) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 726) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11744. Method: conceptual translation. FEATURES Location/Qualifiers source 1..726 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..726 /product="Nup84p" /calculated_mol_wt="83504" Region 66..722 /region_name="Nup84_Nup100" /note="Nuclear pore protein 84 / 107; pfam04121" /db_xref="CDD:461184" CDS 1..726 /gene="NUP84" /locus_tag="YDL116W" /coded_by="NM_001180175.1:1..2181" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:21818277]" /experiment="EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:11823431|PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:15725626]" /experiment="EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:17538013|PMID:16418532]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:8565072]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:22331846]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16418532]" /experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16418532]" /experiment="EXISTENCE:mutant phenotype:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22110603]" /experiment="EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:8565072]" /note="Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP107" /db_xref="GeneID:851441" /db_xref="SGD:S000002274" ORIGIN 1 melsptyqte rftkfsdtlk efkieqnneq npidpfniir efrsaagqla ldlansgdes 61 nvisskdwel earfwhlvel llvfrnadld ldemelhpyn srglfekklm qdnkqlyqiw 121 ivmvwlkent yvmerpknvp tskwlnsits gglkscdldf plrentnvld vkdkeedhif 181 fkyiyelila gaidealeea klsdnisicm ilcgiqeyln pvidtqiane fntqqgikkh 241 slwrrtvysl sqqagldpye raiysylsga ipnqevlqys dwesdlhihl nqilqteien 301 yllennqvgt delilplpsh altvqevlnr vasrhpsese hpirvlmasv ildslpsvih 361 ssvemlldvv kgteasndii dkpyllrivt hlaicldiin pgsveevdks klittyisll 421 klqglyenip iyatflnesd cleacsfils sledpqvrkk qietinflrl pasnilrrtt 481 qrvfdeteqe yspsneisis fdvnnidmhl iygvewlieg klyvdavhsi ialsrrflln 541 grvkaleqfm ernnigeick nyelekiadn iskdenedqf leeitqyehl ikgireyeew 601 qksvsllsse sniptliekl qgfskdtfel iktflvdlts snfadsadye ilyeiralyt 661 pfllmelhkk lveaakllki pkfisealaf tslvanendk iyllfqssgk lkeyldlvar 721 tatlsn // LOCUS NP_010168 353 aa linear PLN 30-JUN-2025 DEFINITION Iwr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010168 VERSION NP_010168.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180174.1 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11745. On Jul 30, 2007 this sequence version replaced NP_010168.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..353 /product="Iwr1p" /calculated_mol_wt="40509" Region 152..220 /region_name="Iwr1" /note="Transcription factor Iwr1; pfam08574" /db_xref="CDD:430085" CDS 1..353 /gene="IWR1" /locus_tag="YDL115C" /coded_by="NM_001180174.1:1..1062" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21504834|PMID:19679657|PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21504834|PMID:19679657|PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:23267056|PMID:21504834]" /experiment="EXISTENCE:mutant phenotype:GO:0006913 nucleocytoplasmic transport [PMID:21504834]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:21504834]" /note="RNA polymerase II transport factor, conserved from yeast to humans; also has a role in transporting RNA polymerase III into the nucleus; interacts with most of the RNAP II subunits; nucleo-cytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress" /db_xref="GeneID:851442" /db_xref="SGD:S000002273" ORIGIN 1 mstistttap efirvkrrrd edsvqallid egkrvkkqkf ifklsktvss esyqseqess 61 tpllklahed hrhfvleqrk ksrrdsddek sqqrlaaegs tvdddglppe inqmvndylk 121 lnkgvekter kkpsrkyftg dsakiaslps ldyvfdiyhl ekihddevar ynneknigfv 181 kiiehidlal deesdpnear sddedsnden yyqndypede dddrsilfgs egediaalge 241 eivigvnksr fsswnddkiq gsngyhdvee eygdlfnrlg gksdvlksin ssnfidldgq 301 egeieisdne ddsdegddie yprneffptd vddplahhrd rifhqlqkki nrs // LOCUS NP_010169 308 aa linear PLN 30-JUN-2025 DEFINITION short-chain dehydrogenase/reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010169 VERSION NP_010169.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180173.1 REFERENCE 1 (residues 1 to 308) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 308) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 308) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 308) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11746. Method: conceptual translation. FEATURES Location/Qualifiers source 1..308 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..308 /product="short-chain dehydrogenase/reductase" /calculated_mol_wt="34164" Region 40..282 /region_name="17beta-HSDXI-like_SDR_c" /note="human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs; cd05339" /db_xref="CDD:187598" Site order(45,47..50,69..71,89..91,117..119,140,167..169,182, 186,219..222,224..225) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:187598" Site order(94,98,130..131,134..135,138,142..143,146..147,150, 179..181,183..184,187..188,191..192,194..196,198..199, 225..227,270..271,274,279) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:187598" Site order(141,169,182,186) /site_type="active" /db_xref="CDD:187598" Site order(150,153,196,199,209) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:187598" CDS 1..308 /locus_tag="YDL114W" /coded_by="NM_001180173.1:1..927" /note="Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene" /db_xref="GeneID:851444" /db_xref="SGD:S000002272" ORIGIN 1 mvrknkinra sgttkhlkdf psvilslpsy npsilsknat alitggssgl gfelakelsr 61 rinkvivadi qsfptfaqve ynnifyyqcd itsldeiknl kkaierdhgn iniiinnagv 121 ahikklehmt nkeveqlidi nligayriis tfaedmidnr egfiiniasv lgeltparlt 181 sygaskgami gfhkcmsrhf rslstecnkt giktllvcpg kiktnmfidv ptpskllapd 241 iipsqlalai isamehnhlq tlnapyyvnl vpffktlswp yrhllkhfsg mdhvtstspr 301 ainpkrsa // LOCUS NP_010170 640 aa linear PLN 30-JUN-2025 DEFINITION Atg20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010170 VERSION NP_010170.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180172.1 REFERENCE 1 (residues 1 to 640) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 640) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 640) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 640) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11747. Method: conceptual translation. FEATURES Location/Qualifiers source 1..640 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..640 /product="Atg20p" /calculated_mol_wt="72415" Region 7..640 /region_name="COG5391" /note="Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]" /db_xref="CDD:227680" CDS 1..640 /gene="ATG20" /locus_tag="YDL113C" /gene_synonym="CVT20; SNX42" /coded_by="NM_001180172.1:1..1923" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569|PMID:15659643|PMID:12048214]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:12554655]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775|PMID:12048214]" /experiment="EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:12554655]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:12048214]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:12554655]" /experiment="EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:12554655]" /experiment="EXISTENCE:physical interaction:GO:0034498 early endosome to Golgi transport [PMID:12554655]" /note="Sorting nexin family member; required for the cytoplasm-to-vacuole targeting (Cvt) pathway, endosomal sorting and selective autophagy; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate" /db_xref="GeneID:851445" /db_xref="SGD:S000002271" ORIGIN 1 msdlndvqen aklnsetrnt gkaepphgtt eyvaeaeisk ngvgspkksp kkgkvgkgdn 61 nkvetelvht allekdnpfm eegptgftks alleipgmrs hnlknpnedy eddsegllpl 121 nqesnaetcr tslsgsinsm ngetsaseep svsnrkksar ihileakrvs egqgrayiay 181 viqfenstvq rrysdfeslr silirlfpmt lippipekqs iknygksitg ssskyllpse 241 gsgsvdlsls vihasvnnsd eklirhrirm lteflnkllt neeitktsii tdfldpnnhn 301 whefvnssst fsslpksilq cnpldptntt rihamlpipg sssqlllnke sndkkmdker 361 sksftnieqd ykqyenlldn giykynrrtt ktyhdlksdy neigevfaqf aheqaqvgel 421 aeqlsylsna fsgssislek lvgrlyynin eplnesvhma tsarelikyr klkylqnemi 481 kkslnskraq lekleaqnne ykdvdkiidn emskshtinl erpnnntgsg gksyggklfn 541 gfnklasmvk dsvkyqetdp htasinlkke ieqlseslev tendlevisk vikndqlpkf 601 skerevdlse ilkhysrymr nyarqnleiw kevkrhqdfa // LOCUS NP_010171 1436 aa linear PLN 30-JUN-2025 DEFINITION tRNA (guanosine(18)-2'-O)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010171 VERSION NP_010171.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180171.1 REFERENCE 1 (residues 1 to 1436) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1436) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1436) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1436) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11748. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1436 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1436 /product="tRNA (guanosine(18)-2'-O)-methyltransferase" /EC_number="2.1.1.34" /calculated_mol_wt="164918" Region 1286..1431 /region_name="SpoU-like_TRM3-like" /note="SAM-dependent tRNA methylase related to TRM3; cd18091" /db_xref="CDD:349964" Site order(1304..1305,1307..1310,1337,1374,1376,1409..1413, 1417..1419,1421..1422,1425..1426,1429..1430) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:349964" Site order(1365..1367,1388..1392,1394,1407..1409,1411, 1416..1418,1420,1423) /site_type="other" /note="SAM binding site [chemical binding]" /db_xref="CDD:349964" CDS 1..1436 /gene="TRM3" /locus_tag="YDL112W" /coded_by="NM_001180171.1:1..4311" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016423 tRNA (guanine) methyltransferase activity [PMID:9917067]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:9917067]" /experiment="EXISTENCE:mutant phenotype:GO:0002128 tRNA nucleoside ribose methylation [PMID:32053677]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:32053677]" /note="2'-O-ribose methyltransferase; catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs" /db_xref="GeneID:851446" /db_xref="SGD:S000002270" ORIGIN 1 mvggalicky lpreeqlkli sdliqndsle evlelietsp ldittdsnie tpifekiteq 61 viayasidge aremfrssra emnkalrtsa qllcclpsvw hkfqvwmsyr lndiisenyk 121 hlfndnfgkk ivqpffdsfa eeqnanikhe nlhldilsll hylevvylfd eckngisskc 181 ldfiivpllg cnseeiadsc sklmrwhiky lskccntdsn fdkliwtfik qlyaegsqqa 241 wkqknslsfl lrfllaaels pelityiktd aywrhiqtel dndvhehrkl alsilkltiq 301 klsshgitlq ttfykcndla niemlgswkk fttlyemial dtslnqiqaa kqdiikifdn 361 ehlhhswgli llstglkssm esvrkymmtl mfsitnmsaf ssnlplltkt llpaamsahy 421 fdvkgvscph geklslfvnn llsqttegis dilfeilkll vekgtsfdps riylsygilv 481 ffqnnkqkti nsdhlslirk lydfaaeeev lettiqtiyl kfllyidpsv sasellftlv 541 shiklkggty kyveplfedy rdlavshfdd lqakenlttn igkdtifdll asiifdfkdi 601 ditpdfliev akskqdipvy tskavtfltq llsgepsngy tyenatalls ypnftistwk 661 sinvnnlfks vmekfsldkf kffaeiyqkt yecrfdtiel nfndllslye mvkksanqcs 721 resfkvkdsa yssyfellnt flktyalnrd ssegnddelh illrlvdeni nkdngnylgn 781 lavckllyfi idsyihcsts vsdddifivk fifekfsfiw ecinserlvl kerdlhlmli 841 kglfhpvily fgsnqyidtl tskleehaqt iislsysrrs llpllgsqlr vfmkfygkll 901 redvnywwli niivgvfkqp qmdvnlyklk pvisslfdhk lnnyyikgde lyekvygpde 961 ilarvsiids ilyandqlki rliekvtekt nalyaikrtd gaealqrllq wqllllsllt 1021 tnekklsets mirilksied essplvrvyk ewfisskvvd yyktgnpkfa edylfslled 1081 hskpvfvvsa ekicfmvlkd lrndekkygf tqlldrfict lvpnaasnkp lvrhfsnsli 1141 islwptfkay lsdhtlrnii enlysnakkt qifgqyragd aniwdlkgdr kltnmfggvl 1201 kkvtdhdcpy isesvfekyl qekdivpigt derslwldkr dtntesvnna niscdtsplq 1261 tksgawetvl dldnkksndv vtrselivvs slvdkppnlg gicrlcdvlg vglltvqdik 1321 vknhpqfknv avtadrwmpm eevaldeias fmkekkkegy tligleqtdk svkldnnfqf 1381 pkkslillgt eafgipgtll seldlcleiq qfgvirsmni qtatavivhs ytvqhm // LOCUS NP_010172 265 aa linear PLN 30-JUN-2025 DEFINITION exosome non-catalytic core subunit RRP42 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010172 VERSION NP_010172.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180170.1 REFERENCE 1 (residues 1 to 265) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 265) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 265) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 265) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11749. Method: conceptual translation. FEATURES Location/Qualifiers source 1..265 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..265 /product="exosome non-catalytic core subunit RRP42" /calculated_mol_wt="28924" Region 2..264 /region_name="RNase_PH_RRP42" /note="RRP42 subunit of eukaryotic exosome; cd11367" /db_xref="CDD:206772" Site order(2..7,9..10,13..14,17,21,23..26,33,54,204) /site_type="other" /note="Rrp4 interface [polypeptide binding]" /db_xref="CDD:206772" Site order(42..44,49,57,61,63,79,84..85,93,101,125,127,131..132, 217,220..233,240..241,244..245,247..248) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:206772" CDS 1..265 /gene="RRP42" /locus_tag="YDL111C" /coded_by="NM_001180170.1:1..798" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15828860|PMID:17643380]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9390555|PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0016075 rRNA catabolic process [PMID:10508172]" /note="Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7)" /db_xref="GeneID:851447" /db_xref="SGD:S000002269" ORIGIN 1 mslsvaeksy lydslastps irpdgrlphq frpieiftdf lpssngssri iasdgseciv 61 sikskvvdhh venellqvdv diagqrddal vvetitslln kvlksgsgvd ssklqltkky 121 sfkifvdvlv isshshpvsl isfaiysaln stylpklisa fddleveelp tfhdydmvkl 181 dinpplvfil avvgnnmlld paanesevan ngliiswsng kitspirsva lndsnvksfk 241 phllkqglam vekyapdvvr slenl // LOCUS NP_010173 150 aa linear PLN 30-JUN-2025 DEFINITION Tma17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010173 VERSION NP_010173.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180169.1 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11750. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..150 /product="Tma17p" /calculated_mol_wt="16640" CDS 1..150 /gene="TMA17" /locus_tag="YDL110C" /gene_synonym="ADC17" /coded_by="NM_001180169.1:1..453" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005835 fatty acid synthase complex [PMID:32160528]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:32160528]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:25042801]" /experiment="EXISTENCE:direct assay:GO:0070682 proteasome regulatory particle assembly [PMID:25042801]" /experiment="EXISTENCE:mutant phenotype:GO:0006633 fatty acid biosynthetic process [PMID:32160528]" /note="Regulatory gamma subunit of fatty acid synthase (FAS); ATPase dedicated chaperone that adapts proteasome assembly to stress; induced upon stress; interacts with Rpt6p to assist its pairing to Rpt3p and early steps in proteasome biogenesis; associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion" /db_xref="GeneID:851448" /db_xref="SGD:S000002268" ORIGIN 1 mcsaggirrp iqieefktai sgmsdmelaq ikteiensin hlqrsnarlg kyiaklegad 61 drleaddsdd lenidsgdla lykdsvrene ivlnnynerv daleqetvyr ktghgkskhe 121 veakdntnkg pdvdmdnsnv dvvtpnsifi // LOCUS NP_010174 647 aa linear PLN 30-JUN-2025 DEFINITION putative lipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010174 VERSION NP_010174.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180168.1 REFERENCE 1 (residues 1 to 647) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 647) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 647) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 647) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11751. Method: conceptual translation. FEATURES Location/Qualifiers source 1..647 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..647 /product="putative lipase" /calculated_mol_wt="72725" Region 189..387 /region_name="DUF676" /note="Putative serine esterase (DUF676); pfam05057" /db_xref="CDD:309968" CDS 1..647 /locus_tag="YDL109C" /coded_by="NM_001180168.1:1..1944" /note="Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication" /db_xref="GeneID:851449" /db_xref="SGD:S000002267" ORIGIN 1 meagrsadev lyhnqssvkl geleryvity elyqgdsipa ditldslwvk iknttklsyk 61 payllgpfil ycdvrakdye ssykiicsad kpvfqsnlqa qqkfiaelsl hhikpryvwi 121 vdivsqilfn ketkvtfeiv vgnskaslkr kircndslpd kacnilhtgl svhrlttadi 181 wkvprpidms qkshlvilth gfqsnvsadm eylmeeiyka qmnnpnerlv ikgymknace 241 tekgikflgv glanyiidel yddsvgkisf ighslggltq tfaicyiktk ypyffkkvep 301 infislaspl lgiatstpny vkmslsmgii gttgqelglk dgnygdkpll yllseeslis 361 vlarfkrrtl yanavndgiv plysssllfl dysqllqklg gqttapcdpl fqpevspige 421 lpnhsdvand ddginasswn tfwkskennc dkkskrlmna sviksmksvl lspcpdakff 481 sdpdarvati ihdkiytekn lpppsptlye gtaakegetr ktrkemeeii arrwhkgmhw 541 rkvvvllkpd ahnniivrrr fsnaygwpvv dhlvtahfqr ddpiaspmqd kqfaeedinm 601 atggvepnkf yswltkiedp svyhggivst asqlasswis khssvtd // LOCUS NP_010175 306 aa linear PLN 30-JUN-2025 DEFINITION TFIIH complex serine/threonine-protein kinase subunit KIN28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010175 VERSION NP_010175.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180167.1 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11752. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..306 /product="TFIIH complex serine/threonine-protein kinase subunit KIN28" /EC_number="2.7.11.23" /calculated_mol_wt="35116" Region 7..302 /region_name="STKc_CDK7" /note="Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; cd07841" /db_xref="CDD:270833" Site order(13..16,18..19,21,34,36,53,67,83..86,89,91..92,129, 131,133..134,136,147,150,152,162,164..167,169,207..208) /site_type="active" /db_xref="CDD:270833" Site order(13,15..19,21,34,36,67,83..86,133..134,152) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270833" Site order(45..47,49,52..53,55..56,59..60,72,74,79,118,121..124, 152,154..157,161..162,276,280..282) /site_type="other" /note="CDK/cyclin interface [polypeptide binding]" /db_xref="CDD:270833" Site order(53,91,129,131,150,162,164..167,169,207..208) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270833" Site order(146..157,159..169) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270833" CDS 1..306 /gene="KIN28" /locus_tag="YDL108W" /coded_by="NM_001180167.1:1..921" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity [PMID:7760796|PMID:9702190]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14749387]" /experiment="EXISTENCE:direct assay:GO:0070985 transcription factor TFIIK complex [PMID:11839796|PMID:19818408]" /experiment="EXISTENCE:mutant phenotype:GO:0006360 transcription by RNA polymerase I [PMID:12015980]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:7760796|PMID:7783209]" /experiment="EXISTENCE:mutant phenotype:GO:0006370 7-methylguanosine mRNA capping [PMID:22689984]" /experiment="EXISTENCE:mutant phenotype:GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity [PMID:9702190]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:26567215]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:27477907]" /note="Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly; phosphorylates the C-terminal domain (CTD) of RNAPII (Ser5 and Ser7); facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex; minor role in RNAPII transcription; role in RNAPI transcription; regulates Atg1p kinase complex assembly during nitrogen starvation induced autophagy; associates with cyclin Ccl1p; relocalizes to the cytosol in response to hypoxia; ortholog of human CDK7" /db_xref="GeneID:851450" /db_xref="SGD:S000002266" ORIGIN 1 mkvnmeytke kkvgegtyav vylgcqhstg rkiaikeikt sefkdgldms airevkylqe 61 mqhpnvieli difmaydnln lvleflptdl evvikdksil ftpadikawm lmtlrgvyhc 121 hrnfilhrdl kpnnllfspd gqikvadfgl araipaphei ltsnvvtrwy rapellfgak 181 hytsaidiws vgvifaelml ripylpgqnd vdqmevtfra lgtptdrdwp evssfmtynk 241 lqiypppsrd elrkrfiaas eyaldfmcgm ltmnpqkrwt avqclesdyf kelpppsdps 301 sikirn // LOCUS NP_010176 351 aa linear PLN 30-JUN-2025 DEFINITION Mss2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010176 VERSION NP_010176.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180166.1 REFERENCE 1 (residues 1 to 351) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 351) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 351) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 351) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11753. Method: conceptual translation. FEATURES Location/Qualifiers source 1..351 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..351 /product="Mss2p" /calculated_mol_wt="41345" Region 137..341 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" CDS 1..351 /gene="MSS2" /locus_tag="YDL107W" /coded_by="NM_001180166.1:1..1056" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11604502]" /experiment="EXISTENCE:genetic interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11950926]" /experiment="EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11604502]" /experiment="EXISTENCE:physical interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11950926|PMID:17452441]" /note="Peripherally bound inner membrane protein of the mitochondrial matrix; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p" /db_xref="GeneID:851451" /db_xref="SGD:S000002265" ORIGIN 1 mqrfvskfvs tppvpkkfqe ifpkkrtvnk ilfqldtrlt yhemypiflq vsqntneeni 61 pwrkkypyir ssdimqmrnv litlrtqnkf vhkdllamed kllniaaelg nndaisilsf 121 nviheykken vkssyekdie tanefikkly arnhhltvkl igdlffenkt ydkaekyyqe 181 flklenstkl agevhgklge iqikqvngfl kaekswlsci elleierssr wyfllarlym 241 ssepmkakal lencasigfk ecfktlgfle lnyfnnyera kewfktgmei mdlecffgff 301 dccvkeenfk gardclesvk klgndkdkkt minvflesrk dsiklldkar l // LOCUS NP_010177 559 aa linear PLN 30-JUN-2025 DEFINITION Pho2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010177 VERSION NP_010177.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180165.1 REFERENCE 1 (residues 1 to 559) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 559) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 559) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 559) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11754. Method: conceptual translation. FEATURES Location/Qualifiers source 1..559 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..559 /product="Pho2p" /calculated_mol_wt="63260" Region 53..183 /region_name="COG5576" /note="Homeodomain-containing transcription factor [Transcription]" /db_xref="CDD:227863" CDS 1..559 /gene="PHO2" /locus_tag="YDL106C" /gene_synonym="BAS2; GRF10" /coded_by="NM_001180165.1:1..1680" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:2664469]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:3303332|PMID:7902583|PMID:9566882]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1493793|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006141 regulation of purine nucleobase metabolic process [PMID:1495962]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:genetic interaction:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:7902583|PMID:9566882]" /experiment="EXISTENCE:genetic interaction:GO:0045937 positive regulation of phosphate metabolic process [PMID:3915785]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7902583|PMID:3915785]" /experiment="EXISTENCE:genetic interaction:GO:0120213 regulation of histidine biosynthetic process [PMID:3303332]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:3303332|PMID:7902583|PMID:9566882]" /experiment="EXISTENCE:mutant phenotype:GO:0006141 regulation of purine nucleobase metabolic process [PMID:1495962]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:2196175]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7902583|PMID:3303332]" /experiment="EXISTENCE:mutant phenotype:GO:0120213 regulation of histidine biosynthetic process [PMID:3303332]" /note="Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:851452" /db_xref="SGD:S000002264" ORIGIN 1 mmeefsydhd fnthfatdld ylqhdqqqqq qqqhdqqhnq qqqpqpqpiq tqnlehdhdq 61 htndmsassn asdsgpqrpk rtrakgeald vlkrkfeinp tpslverkki sdligmpekn 121 vriwfqnrra klrkkqhgsn kdtipssqsr diandydrgs tdnnlvttts tssifhdedl 181 tffdriplns nnnyyffdic sitvgswnrm ksgalqrrnf qsikelrnls pikinnimsn 241 atdlmvlisk knseinyffs amanntkilf riffplssvt ncsltletdd diinsnntsd 301 knnsntnndd dnddnsnedn dnssedkrna kdnfgelklt vtrsptfavy flnnapdedp 361 nlnnqwsicd dfsegrqvnd afvggsniph tlkglqkslr fmnslildyk ssneilptin 421 taiptaavpq qniappflnt nssatdsnpn tnledslffd hdllsssitn tnngqgsnng 481 rqaskddtln lldttvnsnn nhnanneenh laqehlsnda divanpndhl lslptdselp 541 ntpdflkntn eltdehrwi // LOCUS NP_010178 402 aa linear PLN 30-JUN-2025 DEFINITION Smc5-Smc6 complex subunit NSE4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010178 VERSION NP_010178.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180164.1 REFERENCE 1 (residues 1 to 402) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 402) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 402) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 402) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11755. Method: conceptual translation. FEATURES Location/Qualifiers source 1..402 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..402 /product="Smc5-Smc6 complex subunit NSE4" /calculated_mol_wt="45990" Region 97..402 /region_name="COG5125" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227454" CDS 1..402 /gene="NSE4" /locus_tag="YDL105W" /gene_synonym="QRI2" /coded_by="NM_001180164.1:1..1209" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391|PMID:15752197]" /note="Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair" /db_xref="GeneID:851453" /db_xref="SGD:S000002263" ORIGIN 1 msstvisrkr rnstvtepds sgetrkqkks rsdekssssk dgdpqlefkv lqgyrdlese 61 mhkgraqvtr tgdigvamdn lnavdslfnk vigiknnglf ahdaramvsi selaqisvrn 121 lkfddsrsmv nlenivnslk rymlkehfkl nniaenrndl tlaadeqsaa dqqeesdgdi 181 drtpddnhtd katssfkats mrhsylqqfs hynefsqfnw frigalynti sknapitdhl 241 mgplsiekkp rvltqrrrnn dqvgekitae kitqhslnst qqettpeqvk kcfkklskkl 301 gpegsinlfk fiidpnsfsr sienlfytsf likegkllme hdeeglptik ikqsishtds 361 rskeierqrr raahqnhiif qmdmptwrkl ikkynitspf ld // LOCUS NP_010179 407 aa linear PLN 30-JUN-2025 DEFINITION putative N(6)-L-threonylcarbamoyladenine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010179 VERSION NP_010179.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180163.1 REFERENCE 1 (residues 1 to 407) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 407) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 407) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11756. Method: conceptual translation. FEATURES Location/Qualifiers source 1..407 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..407 /product="putative N(6)-L-threonylcarbamoyladenine synthase" /EC_number="2.3.1.234" /calculated_mol_wt="45413" Region 35..376 /region_name="ASKHA_NBD_TsaD-like" /note="nucleotide-binding domain (NBD) of TsaD and similar proteins; cd24097" /db_xref="CDD:466947" CDS 1..407 /gene="QRI7" /locus_tag="YDL104C" /coded_by="NM_001180163.1:1..1224" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:33277478]" /experiment="EXISTENCE:direct assay:GO:0002949 tRNA threonylcarbamoyladenosine modification [PMID:23620299]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0008252 nucleotidase activity [PMID:36416748]" /experiment="EXISTENCE:direct assay:GO:0061711 N(6)-L-threonylcarbamoyladenine synthase activity [PMID:23620299]" /experiment="EXISTENCE:mutant phenotype:GO:0072670 mitochondrial tRNA threonylcarbamoyladenosine modification [PMID:21183954]" /note="Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; highly conserved mitochondrial protein; essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification; when directed to the cytoplasm, complements the essential function of Kae1p in the KEOPS complex" /db_xref="GeneID:851454" /db_xref="SGD:S000002262" ORIGIN 1 misikgtgrf lldnyriwqr rafnrpiqlr kgykvlaiet scddtcvsvl drfsksaapn 61 vlanlkdtld sideggiipt kahihhqari gplteralie snaregidli cvtrgpgmpg 121 slsggldfak glavawnkpl igvhhmlghl liprmgtngk vpqfpfvsll vsgghttfvl 181 sraiddheil cdtidiavgd sldkcgrelg fkgtmiarem ekfinqdind qdfalklemp 241 splknsaskr nmlsfsfsaf italrtnltk lgkteiqelp ereirsiayq vqesvfdhii 301 nklkhvlksq pekfknvref vcsggvssnq rlrtkletel gtlnstsffn fyyppmdlcs 361 dnsimigwag ieiweslrlv sdldicpirq wplndllsvd gwrtdql // LOCUS NP_010180 477 aa linear PLN 30-JUN-2025 DEFINITION UDP-N-acetylglucosamine diphosphorylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010180 VERSION NP_010180.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180162.1 REFERENCE 1 (residues 1 to 477) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 477) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 477) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 477) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11757. Method: conceptual translation. FEATURES Location/Qualifiers source 1..477 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..477 /product="UDP-N-acetylglucosamine diphosphorylase" /EC_number="2.7.7.23" /calculated_mol_wt="53345" Region 89..410 /region_name="UDPGlcNAc_PPase" /note="UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; cd04193" /db_xref="CDD:133036" Site order(109,111..112,163,194,219,221..222,250..251,288..289, 302..303,326,383,409) /site_type="active" /note="substrate binding site [active]" /db_xref="CDD:133036" Site order(116,284,302..304,373,400) /site_type="active" /note="dimerization interface [active]" /db_xref="CDD:133036" CDS 1..477 /gene="QRI1" /locus_tag="YDL103C" /gene_synonym="UAP1" /coded_by="NM_001180162.1:1..1434" /experiment="EXISTENCE:direct assay:GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity [PMID:9603950]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006048 UDP-N-acetylglucosamine biosynthetic process [PMID:9603950]" /note="UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851455" /db_xref="SGD:S000002261" ORIGIN 1 mtdtkqlfie agqsqlfhnw eslsrkdqee llsnleqiss krspaklled cqnaikfsla 61 nsskdtgvei splpptsyes lignskkene ywrlgleaig kgevavilma ggqgtrlgss 121 qpkgcydigl pskkslfqiq aeklirlqdm vkdkkveipw yimtsgptra ateayfqehn 181 yfglnkeqit ffnqgtlpaf dltgkhflmk dpvnlsqspd gngglyraik enklnedfdr 241 rgikhvymyc vdnvlskiad pvfigfaikh gfelatkavr krdahesvgl iatknekpcv 301 ieyseisnel aeakdkdgll klragnivnh yylvdllkrd ldqwcenmpy hiakkkipay 361 dsvtgkytkp tepngikleq fifdvfdtvp lnkfgclevd rckefsplkn gpgskndnpe 421 tsrlaylklg tswledagai vkdgvlvevs sklsyagenl sqfkgkvfdr sgivlek // LOCUS NP_010181 1097 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed DNA polymerase delta POL3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010181 VERSION NP_010181.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180161.2 REFERENCE 1 (residues 1 to 1097) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1097) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1097) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1097) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1097) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1097) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1097) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1097) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1097) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11758. On Apr 26, 2011 this sequence version replaced NP_010181.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1097 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1097 /product="DNA-directed DNA polymerase delta POL3" /EC_number="2.7.7.7" /calculated_mol_wt="124488" Region 90..1095 /region_name="PTZ00166" /note="DNA polymerase delta catalytic subunit; Provisional" /db_xref="CDD:240301" CDS 1..1097 /gene="POL3" /locus_tag="YDL102W" /gene_synonym="CDC2; HPR6; TEX1" /coded_by="NM_001180161.2:1..3294" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:18635534|PMID:1678279]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:15773893]" /experiment="EXISTENCE:direct assay:GO:0006278 RNA-templated DNA biosynthetic process [PMID:17429354]" /experiment="EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:16837458]" /experiment="EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18606574]" /experiment="EXISTENCE:genetic interaction:GO:0045005 DNA-templated DNA replication maintenance of fidelity [PMID:15601866]" /experiment="EXISTENCE:mutant phenotype:GO:0003887 DNA-directed DNA polymerase activity [PMID:1678279]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:1678279]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18606574]" /experiment="EXISTENCE:mutant phenotype:GO:0008296 3'-5'-DNA exonuclease activity [PMID:1648480]" /experiment="EXISTENCE:mutant phenotype:GO:0045004 DNA replication proofreading [PMID:32123096]" /note="Catalytic subunit of DNA polymerase delta; responsible for most of lagging strand DNA synthesis; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)" /db_xref="GeneID:851456" /db_xref="SGD:S000002260" ORIGIN 1 msekrslpmv dvkiddedtp qlekkikrqs idhgvgsepv stieiipsds frkynsqgfk 61 akdtdlmgtq lestfeqels qmehdmadqe ehdlssferk klptdfdpsl ydisfqqida 121 eqsvlngikd entstvvrff gvtseghsvl cnvtgfknyl yvpapnssda ndqeqinkfv 181 hylnetfdha idsievvskq siwgysgdtk lpfwkiyvty phmvnklrta ferghlsfns 241 wfsngtttyd niaytlrlmv dcgivgmswi tlpkgkysmi epnnrvsscq levsinyrnl 301 iahpaegdws htaplrimsf diecagrigv fpepeydpvi qianvvsiag akkpfirnvf 361 tlntcspitg smifshatee emlsnwrnfi ikvdpdviig ynttnfdipy llnrakalkv 421 ndfpyfgrlk tvkqeikesv fsskaygtre tknvnidgrl qldllqfiqr eyklrsytln 481 avsahflgeq kedvhysiis dlqngdsetr rrlavyclkd aylplrlmek lmalvnytem 541 arvtgvpfsy llargqqikv vsqlfrkcle idtvipnmqs qasddqyega tviepirgyy 601 dvpiatldfn slypsimmah nlcyttlcnk atverlnlki dedyvitpng dyfvttkrrr 661 gilpiildel isarkrakkd lrdekdpfkr dvlngrqlal kisansvygf tgatvgklpc 721 laisssvtay grtmilktkt avqekycikn gykhdavvvy gdtdsvmvkf gttdlkeamd 781 lgteaakyvs tlfkhpinle fekayfpyll inkkryaglf wtnpdkfdkl dqkglasvrr 841 dscslvsivm nkvlkkilie rnvdgalafv retindilhn rvdiskliis ktlapnytnp 901 qphavlaerm krregvgpnv gdrvdyviig gndklynrae dplfvlenni qvdsryyltn 961 qlqnpiisiv apiigdkqan gmfvvksiki ntgsqkgglm sfikkveack sckgplrkge 1021 gplcsnclar sgelyikaly dvrdleekys rlwtqcqrca gnlhsevlcs nkncdifymr 1081 vkvkkelqek veqlskw // LOCUS NP_010182 513 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase DUN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010182 VERSION NP_010182.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180160.1 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11759. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..513 /product="serine/threonine protein kinase DUN1" /EC_number="2.7.11.1" /calculated_mol_wt="58502" Region 35..137 /region_name="FHA_DUN1-like" /note="forkhead associated (FHA) domain found in Saccharomyces cerevisiae DNA damage response protein kinase DUN1 and similar proteins; cd22683" /db_xref="CDD:438735" Site order(59..62,72..75,77,100,101..104) /site_type="other" /note="putative phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438735" Region 199..479 /region_name="STKc_CAMK" /note="The catalytic domain of CAMK family Serine/Threonine Kinases; cd05117" /db_xref="CDD:270687" Site order(206..210,214,227,229,261,282..285,289,291,327..328, 330,332..333,335,364..365,368,382..386,388) /site_type="active" /db_xref="CDD:270687" Site order(206..209,214,227,229,261,282..285,289,332..333,335, 364..365) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270687" Site order(210,289,291,327..328,330,332,368,382..386,388) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270687" Site order(364..372,382..386) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270687" CDS 1..513 /gene="DUN1" /locus_tag="YDL101C" /coded_by="NM_001180160.1:1..1542" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:11904430|PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:24647101]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:34244791]" /experiment="EXISTENCE:genetic interaction:GO:0031297 replication fork processing [PMID:17158920]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:11904430]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:24647101]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:34244791]" /note="Cell-cycle checkpoint S/T protein kinase; required for transient G2/M arrest after DNA damage, damage-induced transcription, and nuclear-to-cytoplasmic redistribution of Rnr2p-Rnr4p after genotoxic stress and iron deprivation; phosphorylates repair protein Rad55p, transcriptional repressor Sml1p, superoxide dismutase, and ribonucleotide reductase inhibitors Crt1p and Dif1p; functions in the Mec1p pathway to regulate dNTP pools and telomere length; postreplicative repair role" /db_xref="GeneID:851457" /db_xref="SGD:S000002259" ORIGIN 1 mslstkrehs gdvtdssfkr qqrsnkpsse ytclghlvnl ipgkeqkvei tnrnvttigr 61 srscdvilse pdistfhaef hllqmdvdnf qrnlinvidk srngtfingn rlvkkdyilk 121 ngdrivfgks csflfkyass sstdiendde kvssesrsyk nddevfkkpq isatssqnat 181 tsaairklnk trpvsffdky llgkelgagh yalvkeaknk ktgqqvavki fhaqqnddqk 241 knkqfreetn ilmrvqhpni vnlldsfvep isksqiqkyl vlekiddgel ferivrktcl 301 rqdeskalfk qlltglkylh eqniihrdik penillnitr renpsqvqlg pwdedeidiq 361 vkiadfglak ftgemqftnt lcgtpsyvap evltkkgyts kvdlwsagvi lyvclcgfpp 421 fsdqlgppsl keqilqakya fyspywdkid dsvlhlisnl lvlnpderyn idealnhpwf 481 ndiqqqssvs lelqrlqitd nkipktysel scl // LOCUS NP_010183 354 aa linear PLN 30-JUN-2025 DEFINITION guanine nucleotide exchange factor GET3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010183 VERSION NP_010183.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180159.1 REFERENCE 1 (residues 1 to 354) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 354) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 354) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 354) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11760. Method: conceptual translation. FEATURES Location/Qualifiers source 1..354 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..354 /product="guanine nucleotide exchange factor GET3" /calculated_mol_wt="39223" Region 34..334 /region_name="GET3_arsA_TRC40" /note="transport-energizing ATPase, TRC40/GET3/ArsA family; TIGR00345" /db_xref="CDD:273027" Site order(34,57..59,61,63..65,90,133..140,142..144,146..147, 150,168..172,175..176,178..179,247,249..251,253..254, 256..257,260,275..276,309,316..318,320) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:349755" Site order(58..59,61,64..65,90,133..138,168..172,175,247, 250..251,253..254,257,260,275,316..320) /site_type="other" /note="heterotrimer interface [polypeptide binding]" /db_xref="CDD:349755" CDS 1..354 /gene="GET3" /locus_tag="YDL100C" /gene_synonym="ARR4" /coded_by="NM_001180159.1:1..1065" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:18261907]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:20850366]" /experiment="EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12680698]" /experiment="EXISTENCE:direct assay:GO:0034599 cellular response to oxidative stress [PMID:25242142]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:25242142]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:25242142]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:18261907]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:12680698]" /experiment="EXISTENCE:mutant phenotype:GO:0010038 response to metal ion [PMID:12680698]" /experiment="EXISTENCE:mutant phenotype:GO:0071816 tail-anchored membrane protein insertion into ER membrane [PMID:18724936]" /experiment="EXISTENCE:physical interaction:GO:0043529 GET complex [PMID:16269340]" /note="Guanine nucleotide exchange factor for Gpa1p; amplifies G-protein signaling; subunit of the GET complex involved in ATP-dependent Golgi-to-ER trafficking; binds as a dimer to the transmembrane domain of tail-anchored proteins in the cytosol, shielding them from aqueous solvent until the Get1p/Get2p heterodimer releases the substrate and inserts it into the ER membrane; acts as a chaperone under ATP-depleted oxidative stress conditions; protein abundance increases under DNA replication stress" /db_xref="GeneID:851458" /db_xref="SGD:S000002258" ORIGIN 1 mdltvepnlh slitstthkw ifvggkggvg kttsscsiai qmalsqpnkq fllistdpah 61 nlsdafgekf gkdarkvtgm nnlscmeidp saalkdmndm avsrannngs dgqgddlgsl 121 lqggaladlt gsipgideal sfmevmkhik rqeqgegetf dtvifdtapt ghtlrflqlp 181 ntlskllekf geitnklgpm lnsfmgagnv disgklnelk anvetirqqf tdpdlttfvc 241 vciseflsly eterliqeli sydmdvnsii vnqllfaend qehnckrcqa rwkmqkkyld 301 qidelyedfh vvkmplcage irglnnltkf sqflnkeynp itdgkviyel edke // LOCUS NP_010184 341 aa linear PLN 30-JUN-2025 DEFINITION Bug1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010184 VERSION NP_010184.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180158.1 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11761. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..341 /product="Bug1p" /calculated_mol_wt="38163" Region 171..>259 /region_name="PRK11281" /note="mechanosensitive channel MscK; cl46976" /db_xref="CDD:481316" CDS 1..341 /gene="BUG1" /locus_tag="YDL099W" /coded_by="NM_001180158.1:1..1026" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:17261844]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17261844]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17261844]" /experiment="EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:20156967]" /experiment="EXISTENCE:physical interaction:GO:0005801 cis-Golgi network [PMID:17261844]" /experiment="EXISTENCE:physical interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:16269340]" /note="Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes" /db_xref="GeneID:851459" /db_xref="SGD:S000002257" ORIGIN 1 mseqesdevk rmkqleeark rveelkkkkn kknkgkknkn ssatgsigse tpdlegtpge 61 estqeetvka nstksenndq ndvdeeseek eieqvksdps gttekdieei nstssnvgkd 121 daentkkeev qeviknnnde qtadagktie pqeekkivqt qegnepsnts eaaddlfand 181 gneesdfltt ikkqkeedel tklraenekl tqenkqlkfl nmenettvdd lqdqlqeked 241 iinglqndlq tardeliaav eklklaeaka arnttatpiq fadfntssnn ltpsqsvtns 301 gtqvahgnnm evdrvmlnkw rqwnvdmttw rsigsgpime f // LOCUS NP_010185 194 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit SNU23 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010185 VERSION NP_010185.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180157.1 REFERENCE 1 (residues 1 to 194) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 194) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 194) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 194) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11762. Method: conceptual translation. FEATURES Location/Qualifiers source 1..194 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..194 /product="U4/U6-U5 snRNP complex subunit SNU23" /calculated_mol_wt="22548" Region 80..104 /region_name="zf-met" /note="Zinc-finger of C2H2 type; pfam12874" /db_xref="CDD:463736" CDS 1..194 /gene="SNU23" /locus_tag="YDL098C" /coded_by="NM_001180157.1:1..585" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10449419|PMID:11720284]" /note="Component of the U4/U6.U5 snRNP complex; involved in mRNA splicing via spliceosome" /db_xref="GeneID:851460" /db_xref="SGD:S000002256" ORIGIN 1 msnfgrrtwd reeyaeqars gyddrslkat ltpielqalk skytnydhli kgslkdlnkr 61 kltantesls sfkrgkkfgf ycdicnltfk dtlqyidhln hkvhaikfen lfdepliidi 121 rdnddvpqee felcyhnlik dfvevrsmet qskrkrlldt dvekakkvat kpsieseskv 181 sqmmgfsnfa tskk // LOCUS NP_010186 434 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle lid subunit RPN6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010186 VERSION NP_010186.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180156.1 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11763. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..434 /product="proteasome regulatory particle lid subunit RPN6" /calculated_mol_wt="49643" Region 1..434 /region_name="RPN6" /note="26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]; COG5159" /db_xref="CDD:227488" CDS 1..434 /gene="RPN6" /locus_tag="YDL097C" /gene_synonym="NAS4" /coded_by="NM_001180156.1:1..1305" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:9741626]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12486135]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:12486135]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:12486135]" /note="Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851461" /db_xref="SGD:S000002255" ORIGIN 1 mslpgsklee arrlvnekqy neaeqvylsl ldkdssqssa aagasvddkr rneqetsile 61 lgqlyvtmga kdklrefiph steymmqfak sktvkvlktl iekfeqvpds lddqifvcek 121 siefakrekr vflkhslsik latlhyqkkq ykdslalind llrefkkldd kpslvdvhll 181 eskvyhklrn lakskaslta artaansiyc ptqtvaeldl msgilhcedk dyktafsyff 241 esfesyhnlt thnsyekacq vlkymllski mlnliddvkn ilnakytket yqsrgidamk 301 avaeaynnrs lldfntalkq yekelmgdel trshfnalyd tllesnlcki iepfecveis 361 hiskiigldt qqvegklsqm ildkifygvl dqgngwlyvy etpnqdatyd salelvgqln 421 kvvdqlfeka svly // LOCUS NP_010188 817 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-phosphate-mannose-protein mannosyltransferase PMT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010188 VERSION NP_010188.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180154.1 REFERENCE 1 (residues 1 to 817) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 817) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 817) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 817) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11764. Method: conceptual translation. FEATURES Location/Qualifiers source 1..817 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..817 /product="dolichyl-phosphate-mannose-protein mannosyltransferase PMT1" /EC_number="2.4.1.109" /calculated_mol_wt="92545" Region 54..297 /region_name="PMT" /note="Dolichyl-phosphate-mannose-protein mannosyltransferase; pfam02366" /db_xref="CDD:396786" Region 327..516 /region_name="beta-trefoil_MIR_PMT1-like" /note="MIR domain, beta-trefoil fold, found in Saccharomyces cerevisiae dolichyl-phosphate-mannose--protein mannosyltransferase 1 (PMT1) and similar proteins; cd23283" /db_xref="CDD:467754" Site order(388,390,456,460) /site_type="other" /note="sugar binding site [chemical binding]" /db_xref="CDD:467754" Site order(390,513) /site_type="glycosylation" /note="glycosylation site [posttranslational modification]" /db_xref="CDD:467754" Site order(423,480,482,501..502,506) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467754" Region 535..725 /region_name="PMT_4TMC" /note="C-terminal four TMM region of protein-O-mannosyltransferase; pfam16192" /db_xref="CDD:465056" CDS 1..817 /gene="PMT1" /locus_tag="YDL095W" /coded_by="NM_001180154.1:1..2454" /experiment="EXISTENCE:direct assay:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:8543034|PMID:21956107|PMID:8367478]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0035269 protein O-linked mannosylation [PMID:8367478|PMID:8543034]" /experiment="EXISTENCE:direct assay:GO:0097582 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [PMID:12551906]" /experiment="EXISTENCE:direct assay:GO:0097583 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex [PMID:12551906]" /experiment="EXISTENCE:genetic interaction:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:8543034]" /experiment="EXISTENCE:genetic interaction:GO:0032527 protein exit from endoplasmic reticulum [PMID:21147851]" /experiment="EXISTENCE:genetic interaction:GO:0035269 protein O-linked mannosylation [PMID:21231968|PMID:8543034]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:21147851|PMID:18182384]" /experiment="EXISTENCE:genetic interaction:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:21231968|PMID:23704572]" /experiment="EXISTENCE:mutant phenotype:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:8543034|PMID:8367478]" /experiment="EXISTENCE:mutant phenotype:GO:0035269 protein O-linked mannosylation [PMID:8543034|PMID:8367478|PMID:18182384]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:18182384]" /experiment="EXISTENCE:mutant phenotype:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:23704572]" /experiment="EXISTENCE:physical interaction:GO:0097582 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex [PMID:21956107|PMID:8543034]" /note="Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; functions as a heterodimer with Pmt2p but can also pair with Pmt3p; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen" /db_xref="GeneID:851462" /db_xref="SGD:S000002253" ORIGIN 1 mseektykrv eqddpvpeld ikqgpvrpfi vtdpsaelas lrtmvtlkek llvaclavft 61 avirlhglaw pdsvvfdevh fggfasqyir gtyfmdvhpp lakmlyagva slggfqgdfd 121 fenigdsfps ttpyvlmrff saslgaltvi lmymtlrysg vrmwvalmsa icfavensyv 181 tisryillda plmffiaaav ysfkkyemyp anslnayksl latgialgma ssskwvglft 241 vtwvgllciw rlwfmigdlt kssksifkva faklafllgv pfalylvffy ihfqsltldg 301 dgasffspef rstlknnkip qnvvadvgig siislrhlst mggylhshsh nypagseqqq 361 stlyphmdan ndwllelyna pgeslttfqn ltdgtkvrlf htvtrcrlhs hdhkppvses 421 sdwqkevscy gysgfdgdan ddwvveidkk nsapgvaqer vialdtkfrl rhamtgcylf 481 shevklpawg feqqevtcas sgrhdltlwy vennsnpllp edtkrisykp asfiskfies 541 hkkmwhinkn lvephvyesq ptswpfllrg isywgennrn vyllgnaivw wavtafigif 601 glivitelfs wqlgkpilkd skvvnfhvqv ihyllgfavh yapsflmqrq mflhhylpay 661 yfgilalgha ldiivsyvfr skrqmgyavv itflaasvyf fksfspiiyg tpwtqelcqk 721 sqwlsgwdyn cntyfsslee yknqtltkre sqpaatstve eitiegdgps yedlmnedgk 781 kifkdtegne ldpevvkkml eeeganilkv ekravle // LOCUS NP_010190 743 aa linear PLN 30-JUN-2025 DEFINITION putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010190 VERSION NP_010190.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180152.1 REFERENCE 1 (residues 1 to 743) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 743) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 743) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 743) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11765. Method: conceptual translation. FEATURES Location/Qualifiers source 1..743 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..743 /product="putative dolichyl-phosphate-mannose-protein mannosyltransferase PMT5" /EC_number="2.4.1.109" /calculated_mol_wt="84645" Region 51..293 /region_name="PMT" /note="Dolichyl-phosphate-mannose-protein mannosyltransferase; pfam02366" /db_xref="CDD:396786" Region 323..512 /region_name="beta-trefoil_MIR_PMT1-like" /note="MIR domain, beta-trefoil fold, found in Saccharomyces cerevisiae dolichyl-phosphate-mannose--protein mannosyltransferase 1 (PMT1) and similar proteins; cd23283" /db_xref="CDD:467754" Site order(384,386,452,456) /site_type="other" /note="sugar binding site [chemical binding]" /db_xref="CDD:467754" Site order(386,509) /site_type="glycosylation" /note="glycosylation site [posttranslational modification]" /db_xref="CDD:467754" Site order(419,476,478,497..498,502) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467754" Region 531..720 /region_name="PMT_4TMC" /note="C-terminal four TMM region of protein-O-mannosyltransferase; pfam16192" /db_xref="CDD:465056" CDS 1..743 /gene="PMT5" /locus_tag="YDL093W" /coded_by="NM_001180152.1:1..2232" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0097584 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex [PMID:12551906]" /experiment="EXISTENCE:direct assay:GO:0097585 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex [PMID:12551906]" /note="Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals" /db_xref="GeneID:851464" /db_xref="SGD:S000002251" ORIGIN 1 mnkehllkvd pipdvtikrg plrsflitkp cdnlsslrtv tsskekllvg clliftaivr 61 lhnislpnsv vfgenevgtf vsqyvnniff tdvhpplvam lyatvssvfg ykglfnygni 121 gteytanvpy vamrffsatl givsvlvlyl tlrvsgvkia vaaicavcfa iensfvtlsr 181 ftliegpfvf fmacavyffr rselylpnsc kanksllaas ialgfavssk waglftiawa 241 giivlwrvwf migdlsrpig ssikymafqf tcllaipafi yflifsvhik tlnvngisss 301 ffpaefrktl kynnviketv aevavgsavs lnhvgtaggy lhshlhnypa gsmqqqvtly 361 phidqnnkwi ielaehpnen vtsfqnltdg tiiklrqlkn gcrlhshdhk ppvsqnadwq 421 kevscygyeg fegdinddwi ieidkkrsep gpaqehirai etkfrlkhyl tgcylfshpe 481 klpewgfgqq evtcayfare dltswyieen eneislpnpe kvsykkmsfw qkfvaihkfm 541 fylnnymdts hayssepktw plmlrgidfw nengrevyfl gnavlwwsvt afictfiigv 601 avellawklg vnilrdkhii nfhyqvfqyl lgfaahyfpy ffvgqklfly dylpayyfgi 661 lafghaldli styisnkrnn tgyivvaifm vvcfyffseh spliyatgws snlckrskwl 721 gswdfycnsl llsdshyeln aes // LOCUS NP_010191 146 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding signal recognition particle subunit SRP14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010191 VERSION NP_010191.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180151.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11766. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..146 /product="RNA-binding signal recognition particle subunit SRP14" /calculated_mol_wt="16299" Region 7..120 /region_name="SRP14" /note="Signal recognition particle 14kD protein; pfam02290" /db_xref="CDD:460524" CDS 1..146 /gene="SRP14" /locus_tag="YDL092W" /coded_by="NM_001180151.1:1..441" /experiment="EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]" /experiment="EXISTENCE:direct assay:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:10921896]" /experiment="EXISTENCE:direct assay:GO:0008312 7S RNA binding [PMID:10573124]" /note="Signal recognition particle (SRP) subunit; interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14" /db_xref="GeneID:851466" /db_xref="SGD:S000002250" ORIGIN 1 mantgclspg aflskvpeff qtanekhitv rltakrlieh dpvegnlefd stnhpdydvs 61 kkaseisvss rsdreyplli rmsygshdkk tkcstvvkas eldqfwqeys svfkggmqnl 121 ikkkkkkskn gtisktgkkn kvakkn // LOCUS NP_010192 455 aa linear PLN 30-JUN-2025 DEFINITION clathrin-mediated endocytosis regulator UBX3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010192 VERSION NP_010192.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180150.1 REFERENCE 1 (residues 1 to 455) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 455) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 455) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 455) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11767. Method: conceptual translation. FEATURES Location/Qualifiers source 1..455 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..455 /product="clathrin-mediated endocytosis regulator UBX3" /calculated_mol_wt="52812" Region 151..274 /region_name="UAS" /note="UAS domain; smart00594" /db_xref="CDD:214737" Region <271..>360 /region_name="DUF5401" /note="Family of unknown function (DUF5401); pfam17380" /db_xref="CDD:375164" Region 357..452 /region_name="UBX" /note="UBX domain; pfam00789" /db_xref="CDD:395637" CDS 1..455 /gene="UBX3" /locus_tag="YDL091C" /coded_by="NM_001180150.1:1..1368" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:26362318]" /experiment="EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:26362318]" /experiment="EXISTENCE:direct assay:GO:0044695 Dsc E3 ubiquitin ligase complex [PMID:22681890]" /experiment="EXISTENCE:genetic interaction:GO:0140624 EGAD pathway [PMID:31368600]" /experiment="EXISTENCE:mutant phenotype:GO:0072583 clathrin-dependent endocytosis [PMID:26362318]" /experiment="EXISTENCE:mutant phenotype:GO:0140624 EGAD pathway [PMID:31368600]" /note="Clathrin-coated vesicle component, regulator of endocytosis; subunit of the DSC ubiquitin ligase complex; involved in the endosome and Golgi-associated degradation pathway (EGAD), contributing to proteostasis and lipid homeostasis; required for efficient clathrin-mediated endocytosis; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; ortholog of fission yeast dsc5" /db_xref="GeneID:851467" /db_xref="SGD:S000002249" ORIGIN 1 mdifrhtfgn nddsfiripg afreeppadl ngrtedqnsn tneptqsrdg rlksilhflf 61 qaplivlyyl lnfivrssrl lkpllrlhgf yqrkhnrlld hssqlhrlle nleneaqavt 121 csegngnndd gsntdstsnn essgvqfsfg slynpengtf sksimqnsyt elldacseqv 181 kfgviylhdp lldnhmdyvn kilcseafvn mirkyqvllw ygdvttsegl qvsnalkirq 241 ypllgiislk aekkieliar vegsisnyka qdleaifskn ysrliqlrqq rqniemqrli 301 rqqqdsryqd slrrdqqres erleqtqreq merehqrien qwllwrksql kpepssdkda 361 skvairleng qrlvrkfdas lpteeiyafv elqlhdmlns endtlpvyqp anyqhqysfk 421 litpvprrel dlstkisdvs giypsgnivm erlde // LOCUS NP_010193 431 aa linear PLN 30-JUN-2025 DEFINITION protein farnesyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010193 VERSION NP_010193.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180149.1 REFERENCE 1 (residues 1 to 431) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 431) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 431) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 431) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11768. Method: conceptual translation. FEATURES Location/Qualifiers source 1..431 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..431 /product="protein farnesyltransferase" /EC_number="2.5.1.58" /calculated_mol_wt="48059" Region 80..374 /region_name="FTase" /note="Protein farnesyltransferase (FTase)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). FTases are a subgroup of PTase family of lipid-modifying enzymes. PTases catalyze the...; cd02893" /db_xref="CDD:239223" Site order(101,104..105,108,112,156,158..159,161..162,211, 214..215,258,260,264,307,309..310,313,353,362..363) /site_type="active" /note="active site cavity [active]" /db_xref="CDD:239223" Site order(104..105,108,158..159,211,307,353) /site_type="active" /note="peptide binding pocket [active]" /db_xref="CDD:239223" Site order(108,111,211,214,258,260,264,301,304,310,313,362) /site_type="lipid-binding" /note="lipid binding pocket [chemical binding]" /db_xref="CDD:239223" Site order(206,244,255..256,261,285,288,290..291,301..303) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:239223" Site order(307,309,363) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:239223" CDS 1..431 /gene="RAM1" /locus_tag="YDL090C" /gene_synonym="DPR1; FUS8; SCG2; SGP2; STE16" /coded_by="NM_001180149.1:1..1296" /experiment="EXISTENCE:direct assay:GO:0004660 protein farnesyltransferase activity [PMID:9380709]" /experiment="EXISTENCE:direct assay:GO:0005965 protein farnesyltransferase complex [PMID:8424764]" /experiment="EXISTENCE:direct assay:GO:0018343 protein farnesylation [PMID:1763050]" /note="Beta subunit of the CAAX farnesyltransferase (FTase); this complex prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit" /db_xref="GeneID:851468" /db_xref="SGD:S000002248" ORIGIN 1 mrqrvgrsia rakfintall grkrpvmerv vdiahvdssk aiqplmkele tdttearykv 61 lqsvleiydd ekniepaltk efhkmyldva feislppqmt aldasqpwml ywianslkvm 121 drdwlsddtk rkivdklfti spsggpfggg pgqlshlast yaainalslc dnidgcwdri 181 drkgiyqwli slkepnggfk tclevgevdt rgiycalsia tllnilteel tegvlnylkn 241 cqnyeggfgs cphvdeahgg ytfcatasla ilrsmdqinv ekllewssar qlqeergfcg 301 rsnklvdgcy sfwvggsaai leafgygqcf nkhalrdyil yccqekeqpg lrdkpgahsd 361 fyhtnycllg lavaessysc tpndsphnik ctpdrligss kltdvnpvyg lpienvrkii 421 hyfksnlssp s // LOCUS NP_010194 484 aa linear PLN 30-JUN-2025 DEFINITION Nur1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010194 VERSION NP_010194.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180148.1 REFERENCE 1 (residues 1 to 484) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 484) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 484) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 484) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11769. Method: conceptual translation. FEATURES Location/Qualifiers source 1..484 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..484 /product="Nur1p" /calculated_mol_wt="56756" Region 228..313 /region_name="DUF2418" /note="Protein of unknown function (DUF2418); pfam10332" /db_xref="CDD:431217" CDS 1..484 /gene="NUR1" /locus_tag="YDL089W" /coded_by="NM_001180148.1:1..1455" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:25569132]" /experiment="EXISTENCE:mutant phenotype:GO:0043007 maintenance of rDNA [PMID:18997772]" /note="Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; involved in regulating mitotic exit; dephosphorylated by Cdc14p in anaphase, which promotes timely rDNA segregation and allows mitotic progression; interacts with Csm1p and Lrs4p; null mutant has elevated levels of unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery; Cdc28p substrate" /db_xref="GeneID:851469" /db_xref="SGD:S000002247" ORIGIN 1 mgsndlinea yddsevvgee resksawmkr wyqlltspld lqlvinekle minwdayaks 61 lakplgnflt ilffiirllq dnlikpnyyk lnvksgafdl sksnklkefd ylweisssfq 121 nnnqfyafqs wyfvtlrfln nlfrftifil lslnlyvsck fmfgyfktyn lfhlkkefns 181 pnltkhnlkd lskeyyediy kqslwsmlkh ffrgsrddgp hvnqnedeif fqlrkwiptn 241 fminlfvsfs ptaivflsfs dvsftsaiai vfhqyildyi itkrfqrsvd ddlilssaal 301 qeyedkhima rinqcsnidt lssamgtrsk tpriftthsl cgeeirevyn yekrefealp 361 kmtesvpgsr etrikdyggi sqvsdhqshp igfhysprms pyyrdkvldn nlaqsssnen 421 lekggaylpn qdqnrpsksl splrktplsa rqkrfegsef nvlnkndins ilrspkkkkn 481 yhkr // LOCUS NP_010195 528 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin ASM4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010195 VERSION NP_010195.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180147.1 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11770. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..528 /product="FG-nucleoporin ASM4" /calculated_mol_wt="58662" Region 270..389 /region_name="RRM_Nup53p_fungi" /note="RNA recognition motif (RRM) found in yeast nucleoporin Nup53p and similar proteins; cd12721" /db_xref="CDD:410120" CDS 1..528 /gene="ASM4" /locus_tag="YDL088C" /gene_synonym="NUP59" /coded_by="NM_001180147.1:1..1587" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:17897934]" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17897934]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:9864357]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]" /experiment="EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:19414609]" /experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788]" /note="FG-nucleoporin component of central core of nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport; induces membrane tubulation, which may contribute to nuclear pore assembly; ASM4 has a paralog, NUP53, that arose from the whole genome duplication" /db_xref="GeneID:851470" /db_xref="SGD:S000002246" ORIGIN 1 mfgirsgnnn ggftnltsqa pqttqmfqsq sqlqpqpqpq pqqqqqhlqf ngssdasslr 61 fgnslsntvn annyssnign nsinnnnikn gtnnisqhgq gnnpswvnnp kkrftphtvi 121 rrkttkqnss sdinqnddss smnatmrnfs kqnqdskhne rnksaanndi nsllsnfndi 181 ppsvtlqdwq redefgsips lttqfvtdky takktnrsay dskntpnvfd kdsyvriani 241 eqnhldnnyn taetnnkvhe tsskssslsa iivfgypesi sneliehfsh fghimedfqv 301 lrlgrginpn tfrifhnhdt gcdendstvn ksitlkgrnn esnnkkypif tgeswvklty 361 nspssalral qengtifrgs ligcipyskn aveqlagcki dnvddigefn vsmyqnssts 421 stsntpsppn viitdgtllr eddntpagha gnptnisspi vanspnkrld vidgklpfmq 481 nagpnsnipn llrnleskmr qqeakyrnne pagfthklsn wlfgwndl // LOCUS NP_010196 261 aa linear PLN 30-JUN-2025 DEFINITION Luc7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010196 VERSION NP_010196.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180146.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11771. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..261 /product="Luc7p" /calculated_mol_wt="30064" Region 8..261 /region_name="LUC7" /note="U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]; COG5200" /db_xref="CDD:227527" CDS 1..261 /gene="LUC7" /locus_tag="YDL087C" /gene_synonym="EPE1; EXM2" /coded_by="NM_001180146.1:1..786" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:17726058]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:mutant phenotype:GO:0003729 mRNA binding [PMID:17726058]" /experiment="EXISTENCE:mutant phenotype:GO:0005685 U1 snRNP [PMID:10500099]" /experiment="EXISTENCE:mutant phenotype:GO:0006376 mRNA splice site recognition [PMID:10500099]" /note="Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:851471" /db_xref="SGD:S000002245" ORIGIN 1 mstmstpaae qrklveqlmg rdfsfrhnry shqkrdlglh dpkicksylv gecpydlfqg 61 tkqslgkcpq mhltkhkiqy erevkqgktf pefereylai lsrfvnecng qisvalqnlk 121 htaeermkiq qvteeldvld vriglmgqei dsliradevs mgmlqsvklq eliskrkeva 181 krvrnitenv gqsaqqklqv cevcgaylsr ldtdrrladh flgkihlgyv kmredydrlm 241 knnrttnask tattlpgrrf v // LOCUS NP_010197 273 aa linear PLN 30-JUN-2025 DEFINITION carboxymethylenebutenolidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010197 VERSION NP_010197.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180145.1 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11772. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..273 /product="carboxymethylenebutenolidase" /EC_number="3.1.1.45" /calculated_mol_wt="30706" Region 3..229 /region_name="DLH" /note="Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]; COG0412" /db_xref="CDD:440181" CDS 1..273 /locus_tag="YDL086W" /coded_by="NM_001180145.1:1..822" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="Putative carboxymethylenebutenolidase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene" /db_xref="GeneID:851472" /db_xref="SGD:S000002244" ORIGIN 1 mlitetfhdv qtsygttlri yvyspkiagy pqakfpgvil yseiyqvtgp vrrfgqrias 61 egyvvvapai yhnfmgpeal pydvqgtdig neykikkple sydednklcc dllfqlpqfd 121 gkrigstgmc lgghlafral ldkrvtcatc ffptdihsrt lglgqndnsl ervskelgnn 181 qemvlifgta dthvdpqgrd lirktlrdhg vkftfleila aqhafirdef skgrfdsait 241 qsclgflfeq fnrklridlg efvddntple hvc // LOCUS NP_075208 68 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL085C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_075208 VERSION NP_075208.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184455.1 REFERENCE 1 (residues 1 to 68) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 68) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 68) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 68) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11773. Method: conceptual translation. FEATURES Location/Qualifiers source 1..68 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..68 /product="uncharacterized protein" /calculated_mol_wt="7818" CDS 1..68 /locus_tag="YDL085C-A" /coded_by="NM_001184455.1:1..207" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:31659041]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019538 protein metabolic process [PMID:31659041]" /note="Homolog of modifier of aggregation-4 (MOAG-4) from worm and small EDRK-rich factor protein (SERF1a) from human; highly conserved enhancer of amyloid formation of Abeta40 and alpha-synuclein both in vitro and in vivo; protein displays very high degree of disorder, segment spanning residues 36E-65K has strong helical propensity" /db_xref="GeneID:851473" /db_xref="SGD:S000007588" ORIGIN 1 margnqrdla rqknlkkqkd maknqkksgd pkkrmesdae ilrqkqaaad arreaeklek 61 lkaektrr // LOCUS NP_010198 545 aa linear PLN 30-JUN-2025 DEFINITION NADH-ubiquinone reductase (H(+)-translocating) NDE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010198 VERSION NP_010198.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180144.1 REFERENCE 1 (residues 1 to 545) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 545) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 545) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 545) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11774. Method: conceptual translation. FEATURES Location/Qualifiers source 1..545 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..545 /product="NADH-ubiquinone reductase (H(+)-translocating) NDE2" /EC_number="1.6.5.9" /calculated_mol_wt="61528" Region 95..544 /region_name="PTZ00318" /note="NADH dehydrogenase-like protein; Provisional" /db_xref="CDD:185553" CDS 1..545 /gene="NDE2" /locus_tag="YDL085W" /gene_synonym="NDH2" /coded_by="NM_001180144.1:1..1638" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9733747]" /experiment="EXISTENCE:mutant phenotype:GO:0019655 glycolytic fermentation to ethanol [PMID:9733747]" /note="Mitochondrial external NADH dehydrogenase; catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain; NDE2 has a paralog, NDE1, that arose from the whole genome duplication" /db_xref="GeneID:851474" /db_xref="SGD:S000002243" ORIGIN 1 mlprlgfart arsihrfkmt qiskpffhst evgkpgpqqk lsksytavfk kwfvrglklt 61 fyttlagtly vsyelykesn ppkqvpqsta fanglkkkel vilgtgwgai sllkkldtsl 121 ynvtvvsprs fflftpllps tpvgtiemks ivepvrsiar rtpgevhyie aealdvdpka 181 kkvmvqsvse deyfvsslsy dylvvsvgak tttfnipgvy gnanflkeie daqnirmklm 241 ktieqassfp vndperkrll tfvvvgggpt gvefaaelqd yinqdlrkwm pdlskemkvi 301 liealpniln mfdktlikya edlfardeid lqvntavkvv eptyirtlqn gqtntdieyg 361 mlvwatgnep idfsktlmsr ipeqtnrrgl lindklellg sensiyaigd ctahtgffpt 421 aqvahqegey lakildkklq ieqlewdmln stdetevsrl qkevnlrksk ldkfnykhmg 481 alayigseta iadlhmgdss yqlkgmfafl fwksaylamc lsirnrilia mdwtkvyflg 541 rdssv // LOCUS NP_010199 446 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase SUB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010199 VERSION NP_010199.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180143.1 REFERENCE 1 (residues 1 to 446) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 446) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 446) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 446) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11775. Method: conceptual translation. FEATURES Location/Qualifiers source 1..446 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..446 /product="ATP-dependent RNA helicase SUB2" /EC_number="3.6.4.13" /calculated_mol_wt="50178" Region 61..270 /region_name="DEADc_DDX39" /note="DEAD-box helicase domain of DEAD box protein 39; cd17950" /db_xref="CDD:350708" Site order(64,82,84..86,89,108..114,215..216) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350708" Region 281..410 /region_name="SF2_C_DEAD" /note="C-terminal helicase domain of the DEAD box helicases; cd18787" /db_xref="CDD:350174" Site order(369,371,396,399..400) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350174" CDS 1..446 /gene="SUB2" /locus_tag="YDL084W" /coded_by="NM_001180143.1:1..1341" /experiment="EXISTENCE:direct assay:GO:0000346 transcription export complex [PMID:11979277]" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:15942929]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:28059701]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006406 mRNA export from nucleus [PMID:11675790|PMID:11696331]" /experiment="EXISTENCE:genetic interaction:GO:0003724 RNA helicase activity [PMID:11156602]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:11156602]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:17960421]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:11696331|PMID:11675790]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:18614048]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:15942929]" /experiment="EXISTENCE:physical interaction:GO:0006406 mRNA export from nucleus [PMID:11675790]" /note="Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56; relocalizes from nucleus to cytoplasm upon DNA replication stress" /db_xref="GeneID:851475" /db_xref="SGD:S000002242" ORIGIN 1 mshegeedll eysdneqeiq idaskaaeag etgaatsate gdnnnntaag dkkgsyvgih 61 stgfkdfllk pelsraiidc gfehpsevqq htipqsihgt dvlcqaksgl gktavfvlst 121 lqqldpvpge vavvvicnar elayqirney lrfskympdv ktavfyggtp iskdaellkn 181 kdtaphivva tpgrlkalvr ekyidlshvk nfvidecdkv leeldmrrdv qeifratprd 241 kqvmmfsatl sqeirpicrr flqnpleifv ddeakltlhg lqqyyiklee reknrklaql 301 lddlefnqvi ifvksttran eltkllnasn fpaitvhghm kqeeriaryk afkdfekric 361 vstdvfgrgi dierinlain ydltneadqy lhrvgragrf gtkglaisfv sskedeevla 421 kiqerfdvki aefpeegidp stylnn // LOCUS NP_010200 143 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS9 RPS16B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010200 VERSION NP_010200.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180142.1 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11776. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..143 /product="40S ribosomal protein uS9 RPS16B" /calculated_mol_wt="15716" Region 3..143 /region_name="PLN00210" /note="40S ribosomal protein S16; Provisional" /db_xref="CDD:177799" CDS 1..143 /gene="RPS16B" /locus_tag="YDL083C" /coded_by="NM_001180142.1:1..432" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:genetic interaction:GO:0006413 translational initiation [PMID:30481328]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication" /db_xref="GeneID:851476" /db_xref="SGD:S000002241" ORIGIN 1 msavpsvqtf gkkksatava hvkagkglik vngspitlve peilrfkvye plllvgldkf 61 snidirvrvt ggghvsqvya irqaiakglv ayhqkyvdeq sknelkkaft sydrtlliad 121 srrpepkkfg gkgarsrfqk syr // LOCUS NP_010201 199 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL13 RPL13A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010201 VERSION NP_010201.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180141.1 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11777. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..199 /product="60S ribosomal protein eL13 RPL13A" /calculated_mol_wt="22423" Region 8..175 /region_name="Ribosomal_L13e" /note="Ribosomal protein L13e; pfam01294" /db_xref="CDD:460150" CDS 1..199 /gene="RPL13A" /locus_tag="YDL082W" /coded_by="NM_001180141.1:1..600" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication" /db_xref="GeneID:851477" /db_xref="SGD:S000002240" ORIGIN 1 maisknlpil knhfrkhwqe rvkvhfdqag kkvsrrnara traakiaprp ldllrpvvra 61 ptvkynrkvr agrgftlaev kaagltaaya rtigiavdhr rqnrnqeifd anvqrlkeyq 121 skiivfprng kapeaeqvls aaatfpiaqp atdvearavq dngesafrtl rlarsekkfr 181 girekrarek aeaeaekkk // LOCUS NP_010202 106 aa linear PLN 30-JUN-2025 DEFINITION ribosomal protein P1 RPP1A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010202 VERSION NP_010202.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180140.1 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11778. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..106 /product="ribosomal protein P1 RPP1A" /calculated_mol_wt="10777" Region 4..105 /region_name="Ribosomal_P1" /note="Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins...; cd05831" /db_xref="CDD:100109" CDS 1..106 /gene="RPP1A" /locus_tag="YDL081C" /gene_synonym="RPLA1" /coded_by="NM_001180140.1:1..321" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:24391917]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:1601875]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:1601875]" /note="Ribosomal stalk protein P1 alpha; involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P1 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component" /db_xref="GeneID:851478" /db_xref="SGD:S000002239" ORIGIN 1 mstesalsya aliladseie isseklltlt naanvpveni wadifakald gqnlkdllvn 61 fsagaaapag vaggvaggea geaeaekeee eakeesdddm gfglfd // LOCUS NP_010203 609 aa linear PLN 30-JUN-2025 DEFINITION branched-chain-2-oxoacid decarboxylase THI3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010203 VERSION NP_010203.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180139.1 REFERENCE 1 (residues 1 to 609) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 609) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 609) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 609) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11779. Method: conceptual translation. FEATURES Location/Qualifiers source 1..609 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..609 /product="branched-chain-2-oxoacid decarboxylase THI3" /EC_number="4.1.1.72" /calculated_mol_wt="68236" Region 1..571 /region_name="PDC1" /note="TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]; COG3961" /db_xref="CDD:443161" CDS 1..609 /gene="THI3" /locus_tag="YDL080C" /gene_synonym="KID1" /coded_by="NM_001180139.1:1..1830" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16194233|PMID:16850348|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16194233]" /experiment="EXISTENCE:mutant phenotype:GO:0090180 positive regulation of thiamine biosynthetic process [PMID:19013460|PMID:16194233]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:19013460]" /experiment="EXISTENCE:physical interaction:GO:0090180 positive regulation of thiamine biosynthetic process [PMID:19013460|PMID:16194233]" /note="Regulatory protein that binds Pdc2p and Thi2p transcription factors; activates thiamine biosynthesis transcription factors Pdc2p and Thi2p by binding to them, but releases and de-activates them upon binding to thiamine pyrophosphate (TPP), the end product of the pathway; has similarity to decarboxylases but enzymatic activity is not detected" /db_xref="GeneID:851479" /db_xref="SGD:S000002238" ORIGIN 1 mnssytqrya lpkciaisdy lfhrlnqlni htifglsgef smplldklyn ipnlrwagns 61 nelnaayaad gysrlkglgc littfgvgel saingvagsy aehvgilhiv gmpptsaqtk 121 qlllhhtlgn gdftvfhria sdvacyttli idselcadev dkcikkawie qrpvymgmpv 181 nqvnlpiesa rlntpldlql hkndpdveke visrilsfiy ksqnpaiivd actsrqnlie 241 etkelcnrlk fpvfvtpmgk gtvnetdpqf ggvftgsisa pevrevvdfa dfiivigcml 301 sefststfhf qyktkncall ystsvklkna typdlsikll lqkilanlde sklsyqpseq 361 psmmvprpyp agnvllrqew vwneishwfq pgdiiitetg asafgvnqtr fpvntlgisq 421 alwgsvgytm gaclgaefav qeinkdkfpa tkhrvilfmg dgafqltvqe lstivkwglt 481 pyifvmnnqg ysvdrflhhr sdasyydiqp wnylgllrvf gctnyetkki itvgefrsmi 541 sdpnfatndk irmieimlpp rdvpqalldr wvvekeqskq vqeenenssa vntptpefqp 601 llkknqvgy // LOCUS NP_010204 501 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase MRK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010204 VERSION NP_010204.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180138.1 REFERENCE 1 (residues 1 to 501) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 501) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 501) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 501) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11780. Method: conceptual translation. FEATURES Location/Qualifiers source 1..501 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..501 /product="putative serine/threonine protein kinase MRK1" /EC_number="2.7.11.1" /calculated_mol_wt="57688" Region 159..449 /region_name="STKc_GSK3" /note="The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; cd14137" /db_xref="CDD:271039" Site order(170..174,178,191,193,204,218,239..242,245,247..248, 289,291,293..294,296,308,311,322,324..327,329,367) /site_type="active" /db_xref="CDD:271039" Site order(170..173,178,191,193,218,239..242,245,291,293..294, 296,308) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271039" Site order(174..175,320..328,336..337,368..372,374..375,379, 399..402) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:271039" Site order(204,247,289,291,311,322,324..327,329,367) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271039" Site order(307..317,319..329) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271039" Site order(336,371..372,374..375,378..379,399..404) /site_type="other" /note="axin binding site [polypeptide binding]" /db_xref="CDD:271039" CDS 1..501 /gene="MRK1" /locus_tag="YDL079C" /coded_by="NM_001180138.1:1..1506" /experiment="EXISTENCE:genetic interaction:GO:0042176 regulation of protein catabolic process [PMID:10958669]" /note="Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication" /db_xref="GeneID:851480" /db_xref="SGD:S000002237" ORIGIN 1 mtdvlrslvr kisfnnsdnl qlkhktsiqs ntalekkkrk pdtikkvsdv qvhhtvpnfn 61 nsseyindie nliisklidg gkegiavdhi ehanisdskt dgkvankhen issklskekv 121 ekminfdyry iktkertihk rvykhdrktd vdrknhggti disypttevv ghgsfgvvvt 181 tviietnqkv aikkvlqdrr yknreletmk mlchpntvgl qyyfyekdee devylnlvld 241 ympqslyqrl rhfvnlkmqm prveikfyay qlfkalnylh nvprichrdi kpqnllvdpt 301 tfsfkicdfg sakclkpdqp nvsyicsryy rapelmfgat nysnqvdvws sacviaelll 361 gkplfsgesg idqlveiiki mgiptkdeis gmnpnyedhv fpnikpitla eifkaedpdt 421 ldlltktlky hpcerlvplq cllssyfdet krcdtdtyvk aqnlrifdfd vetelghvpl 481 verpaieerl khfvsapsss l // LOCUS NP_010205 343 aa linear PLN 30-JUN-2025 DEFINITION malate dehydrogenase MDH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010205 VERSION NP_010205.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180137.1 REFERENCE 1 (residues 1 to 343) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 343) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 343) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 343) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11781. Method: conceptual translation. FEATURES Location/Qualifiers source 1..343 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..343 /product="malate dehydrogenase MDH3" /EC_number="1.1.1.37" /calculated_mol_wt="37055" Region 3..339 /region_name="MDH_euk_gproteo" /note="malate dehydrogenase, NAD-dependent; TIGR01772" /db_xref="CDD:130833" CDS 1..343 /gene="MDH3" /locus_tag="YDL078C" /coded_by="NM_001180137.1:1..1032" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:7628449|PMID:1447211]" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:8824293]" /experiment="EXISTENCE:direct assay:GO:0030060 L-malate dehydrogenase (NAD+) activity [PMID:1447211]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:7628449]" /experiment="EXISTENCE:mutant phenotype:GO:0006735 NADH regeneration [PMID:7628449]" /experiment="EXISTENCE:mutant phenotype:GO:0030060 L-malate dehydrogenase (NAD+) activity [PMID:1986231|PMID:7628449]" /note="Peroxisomal malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle; mutation in human homolog MDH2 causes early-onset severe encephalopathy" /db_xref="GeneID:851481" /db_xref="SGD:S000002236" ORIGIN 1 mvkvailgas ggvgqplsll lklspyvsel alydiraaeg igkdlshint nsscvgydkd 61 sientlsnaq vvlipagvpr kpgltrddlf kmnagivksl vtavgkfapn arilvisnpv 121 nslvpiavet lkkmgkfkpg nvmgvtnldl vraetflvdy lmlknpkigq eqdkttmhrk 181 vtvigghsge tiipiitdks lvfqldkqye hfihrvqfgg deivkakqga gsatlsmafa 241 gakfaeevlr sfhnekpete slsafvylpg lkngkkaqql vgdnsieyfs lpivlrngsv 301 vsidtsvlek lspreeqlvn tavkelrkni ekgksfilds skl // LOCUS NP_010206 1049 aa linear PLN 30-JUN-2025 DEFINITION Vam6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010206 VERSION NP_010206.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180136.1 REFERENCE 1 (residues 1 to 1049) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1049) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1049) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1049) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1049) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1049) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1049) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1049) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1049) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11782. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1049 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1049 /product="Vam6p" /calculated_mol_wt="122751" Region 603..715 /region_name="Vps39_1" /note="Vacuolar sorting protein 39 domain 1; pfam10366" /db_xref="CDD:371008" Region 756..887 /region_name="Clathrin" /note="Region in Clathrin and VPS; pfam00637" /db_xref="CDD:459884" Region 905..1016 /region_name="Vps39_2" /note="Vacuolar sorting protein 39 domain 2; pfam10367" /db_xref="CDD:402126" CDS 1..1049 /gene="VAM6" /locus_tag="YDL077C" /gene_synonym="CVT4; VPL18; VPL22; VPS39" /coded_by="NM_001180136.1:1..3150" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11853670]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:9111041|PMID:19748353]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:19748353]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:16601699]" /experiment="EXISTENCE:direct assay:GO:0035542 regulation of SNARE complex assembly [PMID:18385512]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:direct assay:GO:0099022 vesicle tethering [PMID:27307091]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026035|PMID:25026036]" /experiment="EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:9111041]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:12730205]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353]" /experiment="EXISTENCE:physical interaction:GO:0030897 HOPS complex [PMID:10944212]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:11062257|PMID:20604902|PMID:18809726|PMID:21325627]" /note="Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p; facilitates tethering and promotes membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; component of vacuole-mitochondrion contacts (vCLAMPs) important for lipid transfer between organelles" /db_xref="GeneID:851482" /db_xref="SGD:S000002235" ORIGIN 1 mlraqklhsl kssditailp teqsqklvla kkngdvevys rdgntlklfq vypdllqnak 61 ndplppvien fyfanelsti faqcketlil lsttnlheyd riidrrginh cwlfershkn 121 keekntyliy stintakmrv liwegrtykn mmeaslsyrk etirsiypge tgitlatdlg 181 iyhwpynkps liriektvkn kfpkdmisal telkeqaekv iekkpkknsh fdaqsfssmd 241 rmsrkssmss lwyrtirner gnkirytfel dgndatpmii dgatkkifkv elmhnneepf 301 liatdhatfs esnsefdhmq ylssnllmly nsstikfvdy engftflqqk ipegikwvkn 361 lsgtyflvwt sndevqlfsy hvddgseddd qesicgdind pdfyqlwrkv lfykffidsp 421 hskelcvsdn peesldicam klrdltvmwc lrifdkfqny mvqlersrns rmirskceem 481 iiksifdlfi kfwappqlvi lkvfpsaiss lvleitgqeh hcllkeaeev ketydipphl 541 lnrwclpylt dtrrhlqnll skenddesri twcyrdreik qsfdfflisn hddvdlntml 601 tlidtvlfkc ylyynppmvg pfirvenhcd shvivtelki rhmfkdlidf yykrgnheea 661 lkfltdlvde lendntdqkq rqkidhgvki lviyylkkls npqldvifty tdwllnrhnd 721 sikeilssif fydsqacssr dhlkvygyik kfdkllaiqy lefaistfrl egnklhtvli 781 klylenldip striklksll ettsvyeprt ilkllndaie sgsdqlptnq lnfvkylkif 841 plsklenhke avhilldeid dykaatsycn dvyqsdstkg eelllylysk lvsiydsnrn 901 sklilnflqd hgsklnsaei yknlpqdisl ydigrvvsql lkkhtskmde trlekallqv 961 elvattykln ermssygvls dshkcpickk visnfgtdsi swftregrni ithyncgkvl 1021 qerfnaknek ssrikqktlg evinelnnk // LOCUS NP_010207 294 aa linear PLN 30-JUN-2025 DEFINITION Rxt3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010207 VERSION NP_010207.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180135.1 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11783. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..294 /product="Rxt3p" /calculated_mol_wt="33681" Region 140..252 /region_name="Rxt3" /note="Histone deacetylation protein Rxt3; pfam08642" /db_xref="CDD:430125" CDS 1..294 /gene="RXT3" /locus_tag="YDL076C" /coded_by="NM_001180135.1:1..885" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286007|PMID:16314178|PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19270272]" /note="Component of the Rpd3L histone deacetylase complex; involved in histone deacetylation; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851483" /db_xref="SGD:S000002234" ORIGIN 1 msvseqdpnr ayretqsqiy klqetllnsa rtknkqeegq esnthsfpeq ymhyqngrns 61 aydlpnvssq svlaftekhy pnklknlgtl yynrfkegsf dedstsysdr hsfpynlydn 121 tlpppflpai giqninniat lkityediqa sfnniesprk rnneiwgcdi ysddsdpilv 181 lrhcgfkiga psggsfhklr rtpvnvtnqd nvtgnlplle gtpfdlevel lflptlqkyp 241 svkrfditsr ewgseatvih dglsygiysi vikqrldrdk phepngyikn lkwt // LOCUS NP_010208 113 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL31 RPL31A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010208 VERSION NP_010208.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180134.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11784. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..113 /product="60S ribosomal protein eL31 RPL31A" /calculated_mol_wt="12822" Region 6..87 /region_name="Ribosomal_L31e" /note="Ribosomal protein L31e; pfam01198" /db_xref="CDD:460108" CDS 1..113 /gene="RPL31A" /locus_tag="YDL075W" /gene_synonym="RPL34" /coded_by="NM_001180134.1:1..342" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:18829863]" /note="Ribosomal 60S subunit protein L31A; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31A has a paralog, RPL31B, that arose from the whole genome duplication" /db_xref="GeneID:851484" /db_xref="SGD:S000002233" ORIGIN 1 maglkdvvtr eytinlhkrl hgvsfkkrap ravkeikkfa klhmgtddvr lapelnqaiw 61 krgvkgveyr lrlrisrkrn eeedaknplf syvepvlvas akglqtvvve eda // LOCUS NP_010209 700 aa linear PLN 30-JUN-2025 DEFINITION E3 ubiquitin-protein ligase BRE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010209 VERSION NP_010209.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180133.1 REFERENCE 1 (residues 1 to 700) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 700) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 700) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 700) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11785. Method: conceptual translation. FEATURES Location/Qualifiers source 1..700 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..700 /product="E3 ubiquitin-protein ligase BRE1" /EC_number="2.3.2.27" /calculated_mol_wt="80561" Region 205..>458 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 441..535 /region_name="BRE1" /note="BRE1 E3 ubiquitin ligase; pfam08647" /db_xref="CDD:462547" Region 641..698 /region_name="RING-HC_Bre1-like" /note="RING finger, HC subclass, found in yeast Bre1 and its homologs from eukaryotes; cd16499" /db_xref="CDD:438162" CDS 1..700 /gene="BRE1" /locus_tag="YDL074C" /coded_by="NM_001180133.1:1..2103" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12876294]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:23103252]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:32214243]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:19531475]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:16783014]" /experiment="EXISTENCE:genetic interaction:GO:0006366 transcription by RNA polymerase II [PMID:15632065]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:23103252]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:12535539]" /experiment="EXISTENCE:mutant phenotype:GO:0031571 mitotic G1 DNA damage checkpoint signaling [PMID:16166626|PMID:16783014]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:15632126]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:15280549]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:19531475]" /experiment="EXISTENCE:physical interaction:GO:0006366 transcription by RNA polymerase II [PMID:19531475]" /experiment="EXISTENCE:physical interaction:GO:0097110 scaffold protein binding [PMID:32214243]" /note="E3 ubiquitin ligase; forms heterodimer with Rad6p to regulate K63 polyubiquitination in response to oxidative stress and to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control; interacts with RNA-binding protein Npl3p, linking histone ubiquitination to mRNA processing; Bre1p-dependent histone ubiquitination promotes pre-mRNA splicing" /db_xref="GeneID:851485" /db_xref="SGD:S000002232" ORIGIN 1 mtaepatkki klelsdpsep ltqsdviafq kealfrcinr rrvdfealrk qyelsrreci 61 dvsrklanim alivtlarfi etfctdanek qlcreiaqgd etlivqrsds fmklltkygk 121 pnttdsntns nasdhiqelt telknlrksk eelfyensql teeisalkey ytniirkydr 181 desftikrvf kedktdavke lredekesne nniksgnkds saingdntsk ksekgdelvq 241 aederkedae nekleldlkf sdlraeinsl sstikdleni rreneeelik trsevsnlkk 301 qqiaaadqdp dfksydhesl lakiqhlteq naelseinss flskfqvlak ekeiytkkvr 361 eefqksldsl vemnsslekd vvrirtardd llskiailea eksktevlsd lqhaidilke 421 qwtkidqrsn dtkssstqda likeiqdlek gfrelsdlth kkyseiinhe sviskltvek 481 tkadqkyfaa mrskdsilie iktlskslsk snelilqlkd sdrllqqkig nlhkqldlsq 541 nnerrlidss ktetlkiidl nntstklkrs leklqeesnk siadmthlet klndteielk 601 hfkqkashle skceklhdtl frgnnknkgs sdealveela nfrtlvycsl csknwknmai 661 ktcghvfcen cckerlaarm rkcptcnkaf ssndlltvhl // LOCUS NP_010210 984 aa linear PLN 30-JUN-2025 DEFINITION Ahk1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010210 VERSION NP_010210.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180132.1 REFERENCE 1 (residues 1 to 984) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 984) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 984) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 984) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 984) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 984) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 984) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 984) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 984) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11786. Method: conceptual translation. FEATURES Location/Qualifiers source 1..984 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..984 /product="Ahk1p" /calculated_mol_wt="113761" Region 422..541 /region_name="DUF1765" /note="Protein of unknown function (DUF1765); pfam08578" /db_xref="CDD:430087" CDS 1..984 /gene="AHK1" /locus_tag="YDL073W" /coded_by="NM_001180132.1:1..2955" /experiment="EXISTENCE:genetic interaction:GO:0001933 negative regulation of protein phosphorylation [PMID:26787842]" /experiment="EXISTENCE:genetic interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:26787842]" /experiment="EXISTENCE:physical interaction:GO:0005078 MAP-kinase scaffold activity [PMID:26787842]" /experiment="EXISTENCE:physical interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:26787842]" /note="Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway; physically interacts with the cytoplasmic domain of Hkr1p, and with Sho1p, Pbs2p, and Ste11p; prevents cross-talk signaling from Hkr1p of the osmotic stress MAPK cascade to the Kss1p MAPK cascade; non-essential gene" /db_xref="GeneID:851486" /db_xref="SGD:S000002231" ORIGIN 1 mgpaihnqly ecglkttsqd gflmdnyetq lfqslnrfin finnanqsas nkeqntkfck 61 sssnflrlkl ltvlrqwcds srsnctlevr dvltqwwvtl lnflnsdtsl qidtalelsl 121 sieltsvcle clskimtili ilpfhssrdm eiyshhlllt ihcitnklil isknskklkr 181 tnsddkcsin dkklqylnky ssllrafigk lnayaffylp edfhfdtill ltvspqisss 241 iqtslfswkk rqykftddqg qmirteafen kdtkffkiiv syikndfvlm sfywhywyii 301 lqfmkfsdsd vgikkstlsc ipgseillth vttrflnsdl nkftriikqt pnprianenv 361 teshpnfksl nssnalitse rindyvfsnf ktiklweclr slsgcilken hpeylenmls 421 lhesllidyv stisaydyia anviynkvlq fiifqfeslp slkfiqwrsw yngllsmlrt 481 knvncqtvsl lclfniwkhv tiedrdeivk vllsdfwesl ifenefplir ilfmkvlvfk 541 iipsvqnsss lrflphdrik qlyeellvnk eelfemqkhd sndivahrkn alvfngnsrl 601 mmipkkpnte dhlvykinhd knltterfps vssvantrpn vilkngkyay dildemtska 661 afllaekktr lnpkknhkim dgyeggqene dndedsedsg shknkrkegn sslsatlntw 721 lskfsstsed sqkkkeqane lgndfeyded vadfaeilpk qsssniekif khgnnsgsmv 781 synssiklnr reniligppe lrfsneikeh nsiatifklv fiqtnrrvve kidlanmkwg 841 tihggskymk plpvpkdlva svaknesetr nlatlcgngl dfeipvpdfn ifgkcmedeq 901 dvakignqnv edlkvtggre vtiwkqiqdm klrtriqkic vlietfnatv reyfefsnrl 961 ehdgifidfe vrkpssnnsi nikv // LOCUS NP_010211 203 aa linear PLN 30-JUN-2025 DEFINITION Yet3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010211 VERSION NP_010211.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180131.1 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11787. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..203 /product="Yet3p" /calculated_mol_wt="22772" Region 1..201 /region_name="COG5374" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227666" CDS 1..203 /gene="YET3" /locus_tag="YDL072C" /coded_by="NM_001180131.1:1..612" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:20378542|PMID:11914276]" /note="hypothetical protein; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851487" /db_xref="SGD:S000002230" ORIGIN 1 mslyytlvfa ilvveifmfs ilalpipsry rrpltllllk pfksstvqva ikcvlgfill 61 lfidcinrvy sidkelqlss asqnngaiia qdrievlsrk ffaqrnmylt gitlfltfvv 121 vrtfglviel ltmkdiyras ppvassdvkk ndsvtaeaaa qsgaskddhg deknfellkk 181 iqdiddeiar lkekseslqe ein // LOCUS NP_010213 638 aa linear PLN 30-JUN-2025 DEFINITION Bdf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010213 VERSION NP_010213.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180129.1 REFERENCE 1 (residues 1 to 638) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 638) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 638) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 638) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 638) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 638) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 638) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 638) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 638) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11788. Method: conceptual translation. FEATURES Location/Qualifiers source 1..638 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..638 /product="Bdf2p" /calculated_mol_wt="72382" Region 55..378 /region_name="COG5076" /note="Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]" /db_xref="CDD:227408" Region <344..419 /region_name="Bromodomain" /note="Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; cl02556" /db_xref="CDD:445827" Site order(349,356,359,398,402,408) /site_type="active" /note="acetyllysine binding site [active]" /db_xref="CDD:99927" Region <472..>537 /region_name="Lebercilin" /note="Ciliary protein causing Leber congenital amaurosis disease; pfam15619" /db_xref="CDD:464776" Region 521..576 /region_name="BET" /note="Bromodomain extra-terminal - transcription regulation; pfam17035" /db_xref="CDD:435704" CDS 1..638 /gene="BDF2" /locus_tag="YDL070W" /coded_by="NM_001180129.1:1..1917" /experiment="EXISTENCE:direct assay:GO:0001046 core promoter sequence-specific DNA binding [PMID:17526728]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:12620224]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0140129 histone H3K56ac reader activity [PMID:20126658]" /experiment="EXISTENCE:genetic interaction:GO:0031452 negative regulation of heterochromatin formation [PMID:16239142]" /experiment="EXISTENCE:mutant phenotype:GO:0031452 negative regulation of heterochromatin formation [PMID:16239142]" /experiment="EXISTENCE:physical interaction:GO:0001094 TFIID-class transcription factor complex binding [PMID:10783167]" /note="Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog, BDF1, that arose from the whole genome duplication" /db_xref="GeneID:851488" /db_xref="SGD:S000002228" ORIGIN 1 msrtnmdtrh ahsallaapq satansrssn sssesssnkn ninvgvgdds gnvsavsidd 61 gphfrdifhy gheenyklas sgitnlnsss hahqtlspis isnastpesf pehplglere 121 tepaleaeme aeelpphqsk yllssikatk rlkdarpflk pvdpialnip hyfnyvqtpm 181 dlslietklq gnvyhsveqv tsdfktmvdn clnfngpess issmakriqk yfekklsamp 241 prvlpasalk ktsrnrkkne dmdsplvirr svsttndnig esgnregvsg grpkrtihpp 301 kskdlfdiye nskpksktlq kkfrtclkil kvlmskknsd infpflqpvd pialnlpnyf 361 dvvknpmdlg tisnnlmnwk yktidqfvdd lnlvfyncfq fnpegnevhs mgkklkelfn 421 fhwlenqdil neietdsdle ednysssyss ddeyddedin enditnpaiq yleqklkkme 481 velqqlkrqe lsklskerkr khlgktllrr kamkhsvddl kksitdkine lsdlemngmi 541 riiknslpad eiltsnedei eidldildea tiariyeryf ekknnnnskr klsgnystap 601 tnkkkktlkf lekdeiinnn nysdseedss dssdsdsd // LOCUS NP_010214 229 aa linear PLN 30-JUN-2025 DEFINITION Cbs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010214 VERSION NP_010214.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180128.1 REFERENCE 1 (residues 1 to 229) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 229) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 229) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 229) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11789. On Oct 2, 2003 this sequence version replaced NP_010214.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..229 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..229 /product="Cbs1p" /calculated_mol_wt="26455" CDS 1..229 /gene="CBS1" /locus_tag="YDL069C" /coded_by="NM_001180128.1:1..690" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:3033440]" /experiment="EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:3033440]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:3033440]" /experiment="EXISTENCE:physical interaction:GO:0005761 mitochondrial ribosome [PMID:15927884]" /note="Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader" /db_xref="GeneID:851491" /db_xref="SGD:S000002227" ORIGIN 1 mlrtkvfatt varisgirry ipirtintvt kkniskiekl cevlevnpdg ykgkeriptk 61 eltkllytts rnmlvrvpmt gdlstgntfe trnetlqklg eqlihleink mltitftnfn 121 qfnimnknfn yihnldrarv vnmdsiswli knslkinqla hlripanlpk emgltsssnd 181 fqnlndwkvi lsfigylkll eikndnkkfi esiikticip linyhlrks // LOCUS NP_010216 59 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c oxidase subunit VIIa [Saccharomyces cerevisiae S288C]. ACCESSION NP_010216 VERSION NP_010216.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180126.1 REFERENCE 1 (residues 1 to 59) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 59) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 59) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 59) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11790. Method: conceptual translation. FEATURES Location/Qualifiers source 1..59 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..59 /product="cytochrome c oxidase subunit VIIa" /calculated_mol_wt="6832" Region 3..55 /region_name="CcO_VIIa_fungal" /note="fungal cytochrome c oxidase subunit VIIa; cd22888" /db_xref="CDD:438622" Site order(3..7,9..10,12..14,16..18,20..22,24..26,28..30,32..34, 36..37,40..41,43..44,47..48,51,55) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:438622" CDS 1..59 /gene="COX9" /locus_tag="YDL067C" /coded_by="NM_001180126.1:1..180" /experiment="EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:7851399|PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0045277 respiratory chain complex IV [PMID:1331058]" /note="Subunit VIIa of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain" /db_xref="GeneID:851492" /db_xref="SGD:S000002225" ORIGIN 1 mtiapitgti krrvimdivl gfslggvmas ywwwgfhmdk inkrekfyae laerkkqen // LOCUS NP_010217 428 aa linear PLN 30-JUN-2025 DEFINITION isocitrate dehydrogenase (NADP(+)) IDP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010217 VERSION NP_010217.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180125.1 REFERENCE 1 (residues 1 to 428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 428) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11791. Method: conceptual translation. FEATURES Location/Qualifiers source 1..428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..428 /product="isocitrate dehydrogenase (NADP(+)) IDP1" /EC_number="1.1.1.42" /calculated_mol_wt="48059" Region 18..424 /region_name="PRK08299" /note="NADP-dependent isocitrate dehydrogenase" /db_xref="CDD:236226" CDS 1..428 /gene="IDP1" /locus_tag="YDL066W" /coded_by="NM_001180125.1:1..1287" /experiment="EXISTENCE:direct assay:GO:0004450 isocitrate dehydrogenase (NADP+) activity [PMID:15574419]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:15001388]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:genetic interaction:GO:0006537 glutamate biosynthetic process [PMID:15574419]" /experiment="EXISTENCE:mutant phenotype:GO:0004450 isocitrate dehydrogenase (NADP+) activity [PMID:8099357]" /note="Mitochondrial NADP-specific isocitrate dehydrogenase; catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes" /db_xref="GeneID:851493" /db_xref="SGD:S000002224" ORIGIN 1 msmlsrrlfs tsrlaafski kvkqpvveld gdemtriiwd kikkklilpy ldvdlkyydl 61 svesrdatsd kitqdaaeai kkygvgikca titpdearvk efnlhkmwks pngtirnilg 121 gtvfrepivi priprlvprw ekpiiigrha hgdqykatdt lipgpgslel vykpsdptta 181 qpqtlkvydy kgsgvamamy ntdesiegfa hssfklaidk klnlflstkn tilkkydgrf 241 kdifqevyea qykskfeqlg ihyehrlidd mvaqmikskg gfimalknyd gdvqsdivaq 301 gfgslglmts ilvtpdgktf eseaahgtvt rhyrkyqkge etstnsiasi fawsrgllkr 361 geldntpalc kfanilesat lntvqqdgim tkdlalacgn nersayvtte efldavekrl 421 qkeiksie // LOCUS NP_010218 342 aa linear PLN 30-JUN-2025 DEFINITION Pex19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010218 VERSION NP_010218.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180124.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11792. On Apr 21, 2006 this sequence version replaced NP_010218.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..342 /product="Pex19p" /calculated_mol_wt="38575" Region 66..342 /region_name="Pex19" /note="Pex19 protein family; pfam04614" /db_xref="CDD:461367" CDS 1..342 /gene="PEX19" /locus_tag="YDL065C" /gene_synonym="PAS12" /coded_by="NM_001180124.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:9418908]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16009135]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:9418908]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:16679311]" /experiment="EXISTENCE:mutant phenotype:GO:0032527 protein exit from endoplasmic reticulum [PMID:16009135]" /experiment="EXISTENCE:mutant phenotype:GO:0032581 ER-dependent peroxisome organization [PMID:20427571]" /experiment="EXISTENCE:mutant phenotype:GO:0045046 protein import into peroxisome membrane [PMID:10637226]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:16679311|PMID:9418908]" /experiment="EXISTENCE:physical interaction:GO:0033328 peroxisome membrane targeting sequence binding [PMID:16679311]" /experiment="EXISTENCE:physical interaction:GO:0045033 peroxisome inheritance [PMID:22486971]" /experiment="EXISTENCE:physical interaction:GO:0050821 protein stabilization [PMID:16679311]" /note="Chaperone and import receptor for newly-synthesized class I PMPs; binds peroxisomal membrane proteins (PMPs) in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane; interacts with Myo2p and contributes to peroxisome partitioning" /db_xref="GeneID:851494" /db_xref="SGD:S000002223" ORIGIN 1 mneneydnfd dlddlldedp tkldeaepdd vqakgsvynd senkeknaes kdsdgvqvan 61 eseedpelke mmvdlqnefa nlmknngnen nvktedfnkl isaleeaakv phqqmeqgcs 121 slksnstdkg tvngsnpgfk nivsntldrl kengnkvdts laeetkesqr sgqnnniddi 181 lsqlldqmva sggkesaenq fdlkdgemdd aitkildqmt skevlyepmk emrsefgvwf 241 qengeneehk ekigtykrqf nivdeivniy elkdydelkh kdrvtellde leqlgdspir 301 sansplkhgn eeeelmkmle idgndpnlgn ldkeltdgck qq // LOCUS NP_010219 157 aa linear PLN 30-JUN-2025 DEFINITION E2 SUMO-conjugating protein UBC9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010219 VERSION NP_010219.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180123.1 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11793. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..157 /product="E2 SUMO-conjugating protein UBC9" /calculated_mol_wt="17780" Region 4..155 /region_name="UBCc_UBE2I" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 I and related proteins; cd23798" /db_xref="CDD:467418" CDS 1..157 /gene="UBC9" /locus_tag="YDL064W" /coded_by="NM_001180123.1:1..474" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16782016]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7800043]" /experiment="EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:9341106|PMID:9435231]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:9435231|PMID:9341106]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:7800043]" /experiment="EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:9435231|PMID:9341106]" /experiment="EXISTENCE:mutant phenotype:GO:0019789 SUMO transferase activity [PMID:9435231]" /note="SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC)" /db_xref="GeneID:851495" /db_xref="SGD:S000002222" ORIGIN 1 msslclqrlq eerkkwrkdh pfgfyakpvk kadgsmdlqk weagipgkeg tnwaggvypi 61 tveypneyps kppkvkfpag fyhpnvypsg ticlsilned qdwrpaitlk qivlgvqdll 121 dspnpnspaq epawrsfsrn kaeydkkvll qakqysk // LOCUS NP_010220 620 aa linear PLN 30-JUN-2025 DEFINITION Syo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010220 VERSION NP_010220.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180122.1 REFERENCE 1 (residues 1 to 620) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 620) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 620) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 620) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11794. Method: conceptual translation. FEATURES Location/Qualifiers source 1..620 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..620 /product="Syo1p" /calculated_mol_wt="70034" Region 15..615 /region_name="Syo1_like" /note="Fungal symportin 1 (syo1) and similar proteins; cd13394" /db_xref="CDD:240521" Site order(301,307,316..317,352,402,405..406,409..410,412..414, 424,451,455,495,500,593,597) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:240521" CDS 1..620 /gene="SYO1" /locus_tag="YDL063C" /coded_by="NM_001180122.1:1..1863" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:26112308]" /experiment="EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:23118189]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:19806183]" /note="Transport adaptor or symportin; assembly chaperone that co-translationally associates with nascent Rpl5p, preventing aggregation; facilitates synchronized nuclear coimport of two 5S-rRNA binding proteins, Rpl5p and Rpl11p, mediated by import receptor Kap104p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus" /db_xref="GeneID:851497" /db_xref="SGD:S000002221" ORIGIN 1 mgrskkrsra sssrlnplrk agsndnnkdt nvvnkklqpl lqnlssvvpn drsialssis 61 vlcedahmrq lllkeklvpi ilnkllndsn sdivvesfgl lrnlsleegy dvsiylwrsd 121 iwtsitsnfg riveslsalq aaeqqpqlkp agkskieskr llfdfadnll slvvalsngs 181 ddilneilte skineifqvi sqllkygvek lpinlfnttl dliydlsses fefidhvsnn 241 ellsqflngl spalhpqane ltkvliegih cqfldmkity dqcnkmihsv chsinnidpv 301 qlvndinnpv eigpatskde sskvitkikd ynakrnesmi klqsieiaid litaiieiva 361 skyespesqe vaipeelint ltnflphvfm ilkdtftsri ligwnnliwl fvslsltels 421 gellttlwsy vtqldsqddl sikigrmgci wallklifpd gafesenral invqmlnnsg 481 fargiieefq nnndlelqqk cinvlstyam iqgqidanke igqffiqtlt qlnvrpeili 541 emtnslfqiy gdasydynep ifvrggflsi lkdqvvpnlr qqfkmvdknk npelkerchd 601 cfttldsfih ykmnenstnq // LOCUS NP_010222 56 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS14 RPS29B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010222 VERSION NP_010222.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180120.1 REFERENCE 1 (residues 1 to 56) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 56) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 56) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 56) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11795. Method: conceptual translation. FEATURES Location/Qualifiers source 1..56 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..56 /product="40S ribosomal protein uS14 RPS29B" /calculated_mol_wt="6597" Region 5..56 /region_name="PTZ00218" /note="40S ribosomal protein S29; Provisional" /db_xref="CDD:185518" CDS 1..56 /gene="RPS29B" /locus_tag="YDL061C" /coded_by="NM_001180120.1:1..171" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480|PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943|PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480|PMID:18782943]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication" /db_xref="GeneID:851498" /db_xref="SGD:S000002219" ORIGIN 1 mahenvwfsh prrfgkgsrq crvcsshtgl vrkydlnicr qcfrekandi gfhkyr // LOCUS NP_010223 788 aa linear PLN 30-JUN-2025 DEFINITION small subunit rRNA maturation protein TSR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010223 VERSION NP_010223.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180119.1 REFERENCE 1 (residues 1 to 788) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 788) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 788) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 788) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11796. Method: conceptual translation. FEATURES Location/Qualifiers source 1..788 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..788 /product="small subunit rRNA maturation protein TSR1" /calculated_mol_wt="90617" Region 4..788 /region_name="COG5177" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227504" CDS 1..788 /gene="TSR1" /locus_tag="YDL060W" /coded_by="NM_001180119.1:1..2367" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11565749]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15167894|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0043021 ribonucleoprotein complex binding [PMID:15167894]" /experiment="EXISTENCE:mutant phenotype:GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11565749]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12089522]" /note="Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress" /db_xref="GeneID:851499" /db_xref="SGD:S000002218" ORIGIN 1 maghshrssl knghksyksk haskgalkrl ykgkvekepv gtgkpdkqvs klqrknkakq 61 lraqrildsi enrklfegkn gaakiitivp lvndldpldi lykllkcadd egimvqevds 121 krifnvhikk fksnlkiiip dmtnflnild cakvadfvvf glsgvqevde efgeqiiral 181 elqgiasyig visnlsavhe kekfqldvkq slesyfkhff pseervynle knsdalnvlr 241 tlcqrlprsi nwrdnrgyvv adfvdfvets pdsgdlvieg tvrgigfnan rlvhipdfgd 301 fqlnkiekis essqkrkiik ekatdslsle ldlqtvfesn mnrdtldeya pegtedwsdy 361 dedfeydglt taryddhgfl pgreqtskka avpkgtsdyq akwylddvid aneeeeaeqt 421 ngkdetmmei ddemmveqdn eevagdeeyd iednegfeel speeeerqlr efrdmekedr 481 efpdeielep sesaierlkr yrglknlync dwqvdekdps spaewkrllr ignykntknr 541 iiketkneaq aiagdrirmf irfpkfllek iqdpkqllfa vyglllhehk navvnfslqr 601 weqydkpvps qepivvqygv rrytiqplfs qgsnspnnvh kyerflhpdt vsvatciapv 661 dftqspaiff kpsptdakni elighgtfln adhsrilakr ailtghpfrf hktvvtvrym 721 ffrpedvewf ksiplftksg rsgfikeslg thgyfkatfd gklsaqdvva mslykrmwpm 781 pslpwngm // LOCUS NP_010224 238 aa linear PLN 30-JUN-2025 DEFINITION Rad59p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010224 VERSION NP_010224.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180118.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11797. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..238 /product="Rad59p" /calculated_mol_wt="26499" Region 47..187 /region_name="Rad52_Rad22" /note="Rad52/22 family double-strand break repair protein; pfam04098" /db_xref="CDD:367812" CDS 1..238 /gene="RAD59" /locus_tag="YDL059C" /coded_by="NM_001180118.1:1..717" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:26540255]" /experiment="EXISTENCE:genetic interaction:GO:0005634 nucleus [PMID:12368472]" /experiment="EXISTENCE:genetic interaction:GO:0045002 double-strand break repair via single-strand annealing [PMID:11606529]" /experiment="EXISTENCE:genetic interaction:GO:2000278 regulation of DNA biosynthetic process [PMID:23824283]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:11238918]" /experiment="EXISTENCE:mutant phenotype:GO:0006277 DNA amplification [PMID:23271978]" /experiment="EXISTENCE:mutant phenotype:GO:0043504 mitochondrial DNA repair [PMID:26540255]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10655498]" /note="Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; regulates replication fork progression in DNA ligase I-deficient cells; paralog of Rad52p" /db_xref="GeneID:851500" /db_xref="SGD:S000002217" ORIGIN 1 mtiqakpsss isydsttygt apgldikefq iiedwngrpa sawsvqrigl lqskieryty 61 niyhnnkygk hnlsklipgh aliqfanetf gydgwrmdvi dvearecqpf tavnngentn 121 tsevkytvva eaqvkvtlkd gtntqcgglg ritlssrgec ynrskkeavg dalkkallsf 181 ekiildyetk itnnyyvdgl ygskkiknea ntnynllsat nskptfikle dakgthik // LOCUS NP_010225 1790 aa linear PLN 30-JUN-2025 DEFINITION Uso1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010225 VERSION NP_010225.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180117.1 REFERENCE 1 (residues 1 to 1790) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1790) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1790) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1790) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11798. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1790 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1790 /product="Uso1p" /calculated_mol_wt="206322" Region 366..715 /region_name="Uso1_p115_head" /note="Uso1 / p115 like vesicle tethering protein, head region; pfam04869" /db_xref="CDD:461460" Region 730..>894 /region_name="CwlO1" /note="Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown]; COG3883" /db_xref="CDD:443091" Region 838..1627 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 1541..>1765 /region_name="EnvC" /note="Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]; COG4942" /db_xref="CDD:443969" CDS 1..1790 /gene="USO1" /locus_tag="YDL058W" /gene_synonym="INT1" /coded_by="NM_001180117.1:1..5373" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:17192843]" /experiment="EXISTENCE:direct assay:GO:0012507 ER to Golgi transport vesicle membrane [PMID:17192843]" /experiment="EXISTENCE:direct assay:GO:0048211 Golgi vesicle docking [PMID:9545229]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8603910]" /experiment="EXISTENCE:mutant phenotype:GO:0035493 SNARE complex assembly [PMID:8603910]" /note="Essential protein involved in vesicle-mediated ER to Golgi transport; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex" /db_xref="GeneID:851501" /db_xref="SGD:S000002216" ORIGIN 1 mdiiqgliqq pkiqsvdeti ptlcdrvens tlisdrrsav lglkafsrqy resviasglk 61 pllntlkrdy mdedsvkail etililfirg dghddltrgw isqqsrlqng kypsplvmkq 121 ekeqvdqfsl wiadaltqse dlihllvefw eidnfhirly tiqlleavma trplkarsal 181 islptsistm vsllddmhep irdeailllm avvndsphvq klvafenife rlfsiieeeg 241 glrgslvvnd clslinnilk yntsnqtlfl etgnlpklah llsepisqde vffwndqriv 301 nintaldivs ltvepgntvt tkhqnallds svlmvvlrla ffhnipkkvr pvalltaanm 361 vrsnehaqle fskidvpyfd pslpvnstan ggpiklipvv silinwmlya nsvhtfdtrv 421 acsrllkayf mdnfdlqrdf llkqvqlcnn stnnvgdnak enggsnksdk esdsdkdtdg 481 kdgteyegsf kanlfevlln ydaelnlnpf klffttdifm fffqqdhkys eelreitrnv 541 ttgndledee plkaiqtise llttsltaad iripisyltf liywlfgdfk atndflsdks 601 viksllsfsy qiqdedvtik clvtmllgva yefsskespf prkeyfefit ktlgkdnyas 661 rikqfkkdsy fskvdmneds iltpeldetg lpkvyfstyf iqlfneniyr irtalshdpd 721 eepinkisfe eveklqrqct klkgeitslq tetesthenl teklialtne hkeldekyqi 781 lnsshsslke nfsiletelk nvrdsldemt qlrdvletkd kenqtalley kstihkqeds 841 iktlekglet ilsqkkkaed ginkmgkdlf alsremqave encknlqkek dksnvnhqke 901 tkslkediaa kiteikaine nleemkiqcn nlskekehis kelveyksrf qshdnlvakl 961 teklkslann ykdmqaenes likaveeskn essiqlsnlq nkidsmsqek enfqiergsi 1021 eknieqlkkt isdleqtkee iisksdsskd eyesqisllk ekletattan denvnkisel 1081 tktreeleae laayknlkne letkletsek alkevkenee hlkeekiqle keatetkqql 1141 nslranlesl ekehedlaaq lkkyeeqian kerqyneeis qlndeitstq qenesikkkn 1201 delegevkam kstseeqsnl kkseidalnl qikelkkkne tneasllesi ksvesetvki 1261 kelqdecnfk ekevseledk lkasedknsk ylelqkesek ikeeldaktt elkiqlekit 1321 nlskakekse selsrlkkts seerknaeeq leklkneiqi knqafekerk llnegsstit 1381 qeysekintl edelirlqne nelkakeidn trselekvsl sndelleekq ntikslqdei 1441 lsykdkitrn dekllsierd nkrdleslke qlraaqeska kveeglkkle eesskekael 1501 ekskemmkkl estiesnete lkssmetirk sdekleqskk saeediknlq heksdlisri 1561 nesekdieel ksklrieaks gseletvkqe lnnaqekiri naeentvlks kledierelk 1621 dkqaeiksnq eekelltsrl keleqeldst qqkaqkseee rraevrkfqv eksqldekam 1681 lletkyndlv nkeqawkrde dtvkkttdsq rqeieklake ldnlkaensk lkeanedrse 1741 iddlmllvtd ldeknakyrs klkdlgveis sdeeddeedd eedeeegqva // LOCUS NP_010226 328 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL057W [Saccharomyces cerevisiae S288C]. ACCESSION NP_010226 VERSION NP_010226.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180116.1 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11799. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..328 /product="uncharacterized protein" /calculated_mol_wt="36556" Region 71..290 /region_name="PldB" /note="Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism]; COG2267" /db_xref="CDD:441868" CDS 1..328 /locus_tag="YDL057W" /coded_by="NM_001180116.1:1..987" /note="hypothetical protein; YDL057W is not an essential gene" /db_xref="GeneID:851502" /db_xref="SGD:S000002215" ORIGIN 1 mekkhvtvqi qsappsyikl eanekfvyit stmnglsyqi aaivsypekr nsstankedg 61 kllckenkla lllhgsqshk naiyqtllak rlaefgywvl ridfrgqgds sdncdpglgr 121 tlaqdledls tvyqtvsdrs lrvqlyktst isldvvvahs rgslamfkfc lklhaaespl 181 pshlincagr ydgrglierc trlhphwqae ggfwangprn geykdfwipl setysiagvc 241 vpefatipqt csvmscygmc dhivpisaas nyarlfegrh slklienadh nyygiegdpn 301 alglpirrgr vnysplvvdl imeylqdt // LOCUS NP_010227 833 aa linear PLN 30-JUN-2025 DEFINITION transcription factor MBP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010227 VERSION NP_010227.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180115.1 REFERENCE 1 (residues 1 to 833) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 833) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 833) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 833) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11800. Method: conceptual translation. FEATURES Location/Qualifiers source 1..833 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..833 /product="transcription factor MBP1" /calculated_mol_wt="93777" Region 22..93 /region_name="KilA-N" /note="KilA-N domain; pfam04383" /db_xref="CDD:367917" Region <392..>549 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Site order(396,400..401,404..406,408..409,413,416,425,427,429, 433..434,484..485,486..487,504,510,512,514,518..519, 522..524,526..527,531,534,543) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 396..425 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 427..510 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 512..543 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..833 /gene="MBP1" /locus_tag="YDL056W" /coded_by="NM_001180115.1:1..2502" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0030907 MBF transcription complex [PMID:8372350]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8372350]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8372350]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8372350]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:30465652]" /note="Transcription factor; involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes" /db_xref="GeneID:851503" /db_xref="SGD:S000002214" ORIGIN 1 msnqiysary sgvdvyefih stgsimkrkk ddwvnathil kaanfakakr trilekevlk 61 ethekvqggf gkyqgtwvpl niakqlaekf svydqlkplf dftqtdgsas pppapkhhha 121 skvdrkkair sastsaimet krnnkkaeen qfqsskilgn ptaaprkrgr pvgstrgsrr 181 klgvnlqrsq sdmgfprpai pnssisttql psirstmgpq sptlgileee rhdsrqqqpq 241 qnnsaqfkei dledglssdv epsqqlqqvf nqntgfvpqq qssliqtqqt esmatsvsss 301 pslptspgdf adsnpfeerf pgggtspiis miprypvtsr pqtsdindkv nkylsklvdy 361 fisnemksnk slpqvllhpp phsapyidap idpelhtafh wacsmgnlpi aealyeagts 421 irstnsqgqt plmrsslfhn sytrrtfpri fqllhetvfd idsqsqtvih hivkrksttp 481 savyyldvvl skikdfspqy rielllntqd kngdtalhia skngdvvffn tlvkmgaltt 541 isnkegltan eimnqqyeqm miqngtnqhv nssntdlnih vntnnietkn dvnsmvimsp 601 vspsdyityp sqiatnisrn ipnvvnsmkq masiyndlhe qhdneikslq ktlksisktk 661 iqvslktlev lkesskdeng eaqtnddfei lsrlqeqntk klrkrliryk rlikqkleyr 721 qtvllnklie detqattnnt vekdnntler lelaqeltml qlqrknklss lvkkfednak 781 ihkyrriire gtemnieevd ssldvilqtl iannnknkga eqiitisnan sha // LOCUS NP_010228 361 aa linear PLN 30-JUN-2025 DEFINITION mannose-1-phosphate guanylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010228 VERSION NP_010228.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180114.1 REFERENCE 1 (residues 1 to 361) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 361) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 361) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 361) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11801. Method: conceptual translation. FEATURES Location/Qualifiers source 1..361 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..361 /product="mannose-1-phosphate guanylyltransferase" /EC_number="2.7.7.13" /calculated_mol_wt="39435" Region 1..234 /region_name="M1P_guanylylT_B_like_N" /note="N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins; cd06425" /db_xref="CDD:133047" Site order(6..9,23,108..110,173) /site_type="active" /note="probable substrate binding site [active]" /db_xref="CDD:133047" Site order(110,219,221) /site_type="active" /note="metal binding site [active]" /db_xref="CDD:133047" Region 256..335 /region_name="LbetaH" /note="Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; cl00160" /db_xref="CDD:469633" Site order(268,270,274,276,286,291,293,303,307..308,310,320,326, 328,330) /site_type="other" /note="putative trimer interface [polypeptide binding]" /db_xref="CDD:100062" Site order(303,305..306,310,322,330) /site_type="other" /note="putative CoA binding site [chemical binding]" /db_xref="CDD:100062" CDS 1..361 /gene="PSA1" /locus_tag="YDL055C" /gene_synonym="MPG1; SRB1; VIG9" /coded_by="NM_001180114.1:1..1086" /experiment="EXISTENCE:direct assay:GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity [PMID:9195935]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0009298 GDP-mannose biosynthetic process [PMID:9195935]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:11055399]" /experiment="EXISTENCE:mutant phenotype:GO:0004475 mannose-1-phosphate guanylyltransferase (GTP) activity [PMID:9195935]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:9195935]" /experiment="EXISTENCE:mutant phenotype:GO:0009298 GDP-mannose biosynthetic process [PMID:9195935]" /note="GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase); synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure" /db_xref="GeneID:851504" /db_xref="SGD:S000002213" ORIGIN 1 mkglilvggy gtrlrpltlt vpkplvefgn rpmilhqiea lanagvtdiv lavnyrpevm 61 vetlkkyeke ygvnitfsve teplgtagpl klaedvlkkd nspffvlnsd viceypfkel 121 adfhkahggk gtivatkvde pskygvivhd iatpnlidrf vekpkefvgn rinaglyiln 181 pevidliemk ptsieketfp ilveekqlys fdlegfwmdv gqpkdflsgt vlylnslakr 241 qpkklatgan ivgnalidpt akisstakig pdvvigpnvt igdgvritrs vvlcnstikn 301 hslvkstivg wnstvgqwcr legvtvlgdd vevkdeiyin ggkvlphksi sdnvpkeaii 361 m // LOCUS NP_010229 486 aa linear PLN 30-JUN-2025 DEFINITION Mch1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010229 VERSION NP_010229.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180113.1 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11802. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..486 /product="Mch1p" /calculated_mol_wt="53435" Region 27..465 /region_name="MFS_MCT_like" /note="Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; cd17314" /db_xref="CDD:340872" Site order(38..39,42..43,46,81,144..145,147..149,152,171, 174..175,178,288,291..292,295..297,300,329,333,390..391, 395,399,415,418..419,422..423,426) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340872" CDS 1..486 /gene="MCH1" /locus_tag="YDL054C" /coded_by="NM_001180113.1:1..1461" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23708375|PMID:19001347|PMID:26928762]" /note="Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport" /db_xref="GeneID:851506" /db_xref="SGD:S000002212" ORIGIN 1 mplskvehyl syhtrlllph vlslqsshrv ayifsllsav stgfitlisl ysqpwqkhln 61 ysswqintia smtnlgmylt ppilgmiads hgpitlslla iigfipsysy layvfnhpel 121 slggngdssf nlsiicfvfi gistsalyfs alltctklyp htkllsislp ttcygissvv 181 gsqllrikwf wssnasssss nsdlnlgrvf qtfalvyvvi gllawiatsv vsllhfneeq 241 dnqkrlddqt dveqspller snhvqekftq tmlrifsdpv tyilavsill slgplemfia 301 nmgsltnllv qldaptlstk llstyalsst ftrlltgiva dffakkkisi kwilltflsl 361 gvcaqlfllk mtssaspwgl vptgslvgiv ygglftvypt lvllvwgers fgtvygslli 421 apaigsmifc mlyakfydsr cmsgggdlrn pscisavyky ssiafvvsav lsavvfwklk 481 srklri // LOCUS NP_010230 185 aa linear PLN 30-JUN-2025 DEFINITION Pbp4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010230 VERSION NP_010230.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180112.1 REFERENCE 1 (residues 1 to 185) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 185) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 185) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 185) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11803. Method: conceptual translation. FEATURES Location/Qualifiers source 1..185 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..185 /product="Pbp4p" /calculated_mol_wt="19750" CDS 1..185 /gene="PBP4" /locus_tag="YDL053C" /coded_by="NM_001180112.1:1..558" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:20368989|PMID:26777405]" /note="Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress; also detected in peroxisomes" /db_xref="GeneID:851507" /db_xref="SGD:S000002211" ORIGIN 1 mtttsttsvd grtsstlkat lsasgpnsng ptpavlpqkp kltgwaqaaa kalprqqqqq 61 qqarkddsva vqpantktkt iastappani kgsstangss tnkkfkrank qpynreevrs 121 ymhklfqsyt agekshsmkt ykqvlsetas grvstatdwg tvsssknknk kygclsdiak 181 vlrnq // LOCUS NP_010231 303 aa linear PLN 30-JUN-2025 DEFINITION 1-acylglycerol-3-phosphate O-acyltransferase SLC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010231 VERSION NP_010231.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180111.1 REFERENCE 1 (residues 1 to 303) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 303) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 303) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 303) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11804. Method: conceptual translation. FEATURES Location/Qualifiers source 1..303 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..303 /product="1-acylglycerol-3-phosphate O-acyltransferase SLC1" /EC_number="2.3.1.51" /EC_number="2.3.1.23" /EC_number="2.3.1.n7" /calculated_mol_wt="33756" Region 60..191 /region_name="AGP_acyltrn" /note="1-acyl-sn-glycerol-3-phosphate acyltransferases; TIGR00530" /db_xref="CDD:129621" Site order(82,85,87,103..106,157..159) /site_type="active" /note="putative acyl-acceptor binding pocket [active]" /db_xref="CDD:153251" CDS 1..303 /gene="SLC1" /locus_tag="YDL052C" /coded_by="NM_001180111.1:1..912" /experiment="EXISTENCE:direct assay:GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity [PMID:9212466]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:24868093]" /experiment="EXISTENCE:genetic interaction:GO:0046474 glycerophospholipid biosynthetic process [PMID:17675291]" /note="1-acyl-sn-glycerol-3-phosphate acyltransferase; catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes" /db_xref="GeneID:851508" /db_xref="SGD:S000002210" ORIGIN 1 msvigrflyy lrsvlvvlal agcgfygvia silctligkq hlaqwitarc fyhvmklmlg 61 ldvkvvgeen lakkpyimia nhqstldifm lgrifppgct vtakkslkyv pflgwfmals 121 gtyfldrskr qeaidtlnkg lenvkknkra lwvfpegtrs ytseltmlpf kkgafhlaqq 181 gkipivpvvv sntstlvspk ygvfnrgcmi vrilkpiste nltkdkigef aekvrdqmvd 241 tlkeigyspa indttlppqa ieyaalqhdk kvnkkiknep vpsvsisndv nthnegssvk 301 kmh // LOCUS NP_010232 275 aa linear PLN 30-JUN-2025 DEFINITION tRNA maturation protein LHP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010232 VERSION NP_010232.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180110.1 REFERENCE 1 (residues 1 to 275) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 275) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 275) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 275) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11805. Method: conceptual translation. FEATURES Location/Qualifiers source 1..275 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..275 /product="tRNA maturation protein LHP1" /calculated_mol_wt="31973" Region 1..>244 /region_name="LHP1" /note="La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]; COG5193" /db_xref="CDD:227520" CDS 1..275 /gene="LHP1" /locus_tag="YDL051W" /gene_synonym="LAH1; YLA1" /coded_by="NM_001180110.1:1..828" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:19749380]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:7799435]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10564276]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:11720288]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11720288]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9150139]" /note="RNA binding protein required for maturation of tRNA and U6 snRNA; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen" /db_xref="GeneID:851509" /db_xref="SGD:S000002209" ORIGIN 1 msekpqqeeq ekpqsrrnsf avieftpevl drclkqvefy fsefnfpydr flrttaeknd 61 gwvpistiat fnrmkkyrpv dkviealrss eilevsadge nvkrrvpldl taarnarieq 121 nqrtlavmnf phedveasqi pelqenleaf fkklgeinqv rlrrdhrnkk fngtvlvefk 181 tipeceaflk sysnddesne ilsyegkkls vltkkqfdlq reasksknfs grsrsfnghk 241 kknlpkfpkn kkkngkeesk edssaiaddd eehke // LOCUS NP_010234 268 aa linear PLN 30-JUN-2025 DEFINITION Knh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010234 VERSION NP_010234.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180108.1 REFERENCE 1 (residues 1 to 268) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 268) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 268) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 268) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11806. Method: conceptual translation. FEATURES Location/Qualifiers source 1..268 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..268 /product="Knh1p" /calculated_mol_wt="29622" Region 26..129 /region_name="Kre9_KNH" /note="Kre9/KNH-like N-terminal Ig-like domain; pfam10342" /db_xref="CDD:463051" Region 164..264 /region_name="Kre9_KNH1_C" /note="Yeast cell wall synthesis protein KRE9/KNH1 C-terminal; pfam05390" /db_xref="CDD:398842" CDS 1..268 /gene="KNH1" /locus_tag="YDL049C" /coded_by="NM_001180108.1:1..807" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:8810042]" /experiment="EXISTENCE:mutant phenotype:GO:0006078 (1->6)-beta-D-glucan biosynthetic process [PMID:8810042]" /note="Protein with similarity to Kre9p; Kre9p is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance" /db_xref="GeneID:851511" /db_xref="SGD:S000002207" ORIGIN 1 mlivlfltlf csvvfrtayc dvaivapepn svydlsgtsq avvkvkwmht dntpqekdfv 61 rytftlcsgt namieamatl qtlsasdltd nefnaiient vgtdgvyfiq vfaqtaigyt 121 ihytnrfklk gmigtkaanp smitiapeaq trittgdvga tidsksftvp ynlqtgvvky 181 apmqlqpatk vtaktwkrky atsevtyyyt lrnsvdqhtt vtpgwsyiit adsnyatpap 241 mpadnggwyn prkrlsltar kvnalrhr // LOCUS NP_010235 490 aa linear PLN 30-JUN-2025 DEFINITION Stp4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010235 VERSION NP_010235.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180107.1 REFERENCE 1 (residues 1 to 490) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 490) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 490) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 490) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11807. Method: conceptual translation. FEATURES Location/Qualifiers source 1..490 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..490 /product="Stp4p" /calculated_mol_wt="54236" Region 14..442 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Site order(260,262..263,266..267,270,285,287..288,291..292,295, 311,313,315,317..318,321..322,325) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 279..296 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 306..326 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..490 /gene="STP4" /locus_tag="YDL048C" /coded_by="NM_001180107.1:1..1473" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Protein containing a Kruppel-type zinc-finger domain; similar to Stp1p, Stp2p; predicted transcription factor; relative distribution to the nucleus increases upon DNA replication stress; STP4 has a paralog, STP3, that arose from the whole genome duplication" /db_xref="GeneID:851512" /db_xref="SGD:S000002206" ORIGIN 1 mlvsssfass idsvmshetm slrrnppfid tpekmpnpta spngtihhli dpslpllsst 61 tsssrstlss tlnspppppl ttsyssynss acqsitsspt dntalahnsk cyfphslspt 121 plssnssshv ilppissftn litvaerefn grsnslhanf tspvprtvld hhrheltfcn 181 pnnttgfkti tpspptqhqs ilptavdnvp rsksvsslpv sgfpplivkq qqqqqlnsss 241 sasalpsihs pltnehtsry ssslkdsaki tkqrkkkecp ichnfyanls thksthltpe 301 drphkcpicq rgfarnndli rhkkrhwkde fmqiyaresd nnsgaddqdd tartsannds 361 ddsndklaas ssseetkllk knqlkslyki kgafkcpyns tlinldmevy phksrslyfe 421 pinchqtgvf srcdtfknhl kalhfeyppk tkkedrgvvp gkckhcglqf pnvdvwlnkh 481 vgkgcgysyh // LOCUS NP_010236 311 aa linear PLN 30-JUN-2025 DEFINITION type 2A-related serine/threonine-protein phosphatase SIT4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010236 VERSION NP_010236.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180106.1 REFERENCE 1 (residues 1 to 311) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 311) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 311) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 311) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11808. Method: conceptual translation. FEATURES Location/Qualifiers source 1..311 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..311 /product="type 2A-related serine/threonine-protein phosphatase SIT4" /EC_number="3.1.3.16" /calculated_mol_wt="35407" Region 7..291 /region_name="MPP_PP2A_PP4_PP6" /note="PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain; cd07415" /db_xref="CDD:277360" Site order(47,63,66..67,70..71,73,75..76,88,103..107,118..119, 122..123,127..128,131..132,140,266,275,285,291) /site_type="other" /note="heterotrimer interface [polypeptide binding]" /db_xref="CDD:277360" Site order(53,55,82,86,114..115,119..120,124,164,186..188,197, 210..212,238,240,265..267) /site_type="active" /db_xref="CDD:277360" Site order(53,55,82,114,164,238) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277360" CDS 1..311 /gene="SIT4" /locus_tag="YDL047W" /gene_synonym="PPH1" /coded_by="NM_001180106.1:1..936" /experiment="EXISTENCE:direct assay:GO:0000159 protein phosphatase type 2A complex [PMID:8600023]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:1848673|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:1848673]" /experiment="EXISTENCE:mutant phenotype:GO:0000159 protein phosphatase type 2A complex [PMID:8600023]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:23864707]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15150670]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:12080055]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:18357452]" /experiment="EXISTENCE:mutant phenotype:GO:0035556 intracellular signal transduction [PMID:12080055]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:12080055]" /experiment="EXISTENCE:mutant phenotype:GO:1903432 regulation of TORC1 signaling [PMID:10604478|PMID:12820961]" /note="Ceramide-activated, type 2A-related serine-threonine phosphatase; functions in G1/S transition of mitotic cycle; controls lifespan, mitochondrial function, cell cycle progression by regulating HXK2 phosphorylation; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6" /db_xref="GeneID:851513" /db_xref="SGD:S000002205" ORIGIN 1 mvsrgpdewl etikkcqalt enemkqlcem vkellmeesn iqpvqtpvtv cgdihgqfhd 61 llelfrtagg fpddinyifl gdyvdrgyys letftllmcl kvkypakitl vrgnhesrqi 121 tqvygfyeec lnkygsttvw kyccqvfdfl tlaaiidgki lcvhgglspe irmldqirvl 181 sraqevpheg gfsdllwsdp dnveawqvsp rgagwlfgsk varefnhvng lnliarahql 241 vmegfkyhfp ekdvvtvwsa pnycyrcgnv asvmkvdedl eptfkifsav pddyiresta 301 nhnnqragyf l // LOCUS NP_010237 173 aa linear PLN 30-JUN-2025 DEFINITION sterol transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_010237 VERSION NP_010237.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180105.1 REFERENCE 1 (residues 1 to 173) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 173) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 173) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 173) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11809. Method: conceptual translation. FEATURES Location/Qualifiers source 1..173 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..173 /product="sterol transporter" /calculated_mol_wt="18932" Region 44..168 /region_name="PG-PI_TP" /note="The phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP) has been shown to bind phosphatidylglycerol and phosphatidylinositol, but the biological significance of this is still obscure. These proteins belong to the ML domain family; cd00917" /db_xref="CDD:238459" Site order(44,57,60,62,67,73,75,77,91,93,95,109,125,132,147,149, 151,153,161,164,166,168) /site_type="other" /note="putative lipid binding cavity [chemical binding]" /db_xref="CDD:238459" CDS 1..173 /gene="NPC2" /locus_tag="YDL046W" /coded_by="NM_001180105.1:1..522" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:16278452]" /experiment="EXISTENCE:direct assay:GO:0001786 phosphatidylserine binding [PMID:33141558]" /experiment="EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:31543266]" /experiment="EXISTENCE:direct assay:GO:0031210 phosphatidylcholine binding [PMID:33141558]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:31543266]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:33141558]" /experiment="EXISTENCE:genetic interaction:GO:0032366 intracellular sterol transport [PMID:16278452]" /note="Sterol transport protein, functional homolog of human NPC2 Niemann-Pick disease type C2 protein; together with Ncr1p mediates integration of ergosterol into vacuolar membrane; functions as general 'lipid solubilizer', binds variety of amphiphilic lipid ligands; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; yeast NPC2 can complement mutations in human NPC2" /db_xref="GeneID:851514" /db_xref="SGD:S000002204" ORIGIN 1 mthslkalfa llflytaavn agvigifnal pppntkping esplyqcdil dkqlveikev 61 nldpnppvrg enltisange vfetieegay idvevrlgyi rllsqtfdlc etledndieg 121 lscpiepgey nikkiveipg evppgkyvvv araytekddl itcltgevif ppr // LOCUS NP_010238 95 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS37 MRP10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010238 VERSION NP_010238.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184304.1 REFERENCE 1 (residues 1 to 95) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 95) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 95) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 95) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11810. Method: conceptual translation. FEATURES Location/Qualifiers source 1..95 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..95 /product="mitochondrial 37S ribosomal protein mS37 MRP10" /calculated_mol_wt="10559" Region 30..64 /region_name="CHCH" /note="CHCH domain; pfam06747" /db_xref="CDD:429096" CDS 1..95 /gene="MRP10" /locus_tag="YDL045W-A" /gene_synonym="mS37" /coded_by="NM_001184304.1:1..288" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978|PMID:9065385]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:9151978|PMID:9065385]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:9065385]" /note="Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs; oxidized by Mia40p during import into mitochondria" /db_xref="GeneID:851515" /db_xref="SGD:S000006430" ORIGIN 1 msgkppvyrl pplprlkvkk piirqeankc lvlmsnllqc wssyghmspk caglvtelks 61 ctsesalgkr nnvqksniny haarlydrin gkphd // LOCUS NP_010239 306 aa linear PLN 30-JUN-2025 DEFINITION FMN adenylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010239 VERSION NP_010239.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180104.1 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11811. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..306 /product="FMN adenylyltransferase" /EC_number="2.7.7.2" /calculated_mol_wt="35415" Region 41..234 /region_name="FAD_synthase" /note="FAD synthase; cd23948" /db_xref="CDD:467513" CDS 1..306 /gene="FAD1" /locus_tag="YDL045C" /coded_by="NM_001180104.1:1..921" /experiment="EXISTENCE:direct assay:GO:0003919 FMN adenylyltransferase activity [PMID:7799934]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7799934]" /experiment="EXISTENCE:direct assay:GO:0006747 FAD biosynthetic process [PMID:7799934]" /experiment="EXISTENCE:mutant phenotype:GO:0006747 FAD biosynthetic process [PMID:7799934]" /note="Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1" /db_xref="GeneID:851516" /db_xref="SGD:S000002203" ORIGIN 1 mqlskaaemc yeitnsylhi dqksqiiast qeairltrky llseifvrws plngeisfsy 61 nggkdcqvll llylsclwey ffikaqnsqf dfefqsfpmq rlptvfidqe etfptlenfv 121 letserycls lyesqrqsga svnmadafrd fikiypetea ivigirhtdp fgealkpiqr 181 tdsnwpdfmr lqpllhwdlt niwsfllysn epicglygkg ftsigginns lpnphlrkds 241 nnpalhfewe iihafgkdae gerssaints pisvvdkerf skyhdnyypg wylvddtler 301 agrikn // LOCUS NP_010240 440 aa linear PLN 30-JUN-2025 DEFINITION Mtf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010240 VERSION NP_010240.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180103.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11812. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..440 /product="Mtf2p" /calculated_mol_wt="51061" Region 211..434 /region_name="Mtf2" /note="Mtf2 family; pfam19189" /db_xref="CDD:437034" CDS 1..440 /gene="MTF2" /locus_tag="YDL044C" /gene_synonym="NAM1" /coded_by="NM_001180103.1:1..1323" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8200349|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:8413192]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:8413192]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:12637560]" /note="Mitochondrial protein that interacts with mitochondrial RNA polymerase; interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription" /db_xref="GeneID:851517" /db_xref="SGD:S000002202" ORIGIN 1 mirtssilkn cnyryihcih rcllneanlk drkthnverv snektfeqal eeerkvfgel 61 feagarvenm rhtnaskiid kyynglqdns egtsvkkeki vfnhsqraqr klpnkdhefl 121 ketagndyvy eraepsaist ktiseqtrtl lekifdedns inksnrelln lnlrkgsgme 181 alrqpvahsn vkfseevmqe ignkiryqtt ldqvlephid ylreavksdy dllrylkqsl 241 diykkrnkdl elkmnaessn ifedirsaci nkpaelpkpl amtlpyiivk slrlgdfdfp 301 adrkytlisy vynecknnmd aslylticnv dfynllvqll wenfqeiryl rrvvtemsvn 361 gvignietvd ildkivkemr slnedvflea geqlsadeev sssankivnv gvlwnkdtnn 421 dllivenylk slkknltrdr // LOCUS NP_010241 266 aa linear PLN 30-JUN-2025 DEFINITION spliceosome assembly protein PRP11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010241 VERSION NP_010241.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180102.1 REFERENCE 1 (residues 1 to 266) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 266) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 266) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 266) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11813. Method: conceptual translation. FEATURES Location/Qualifiers source 1..266 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..266 /product="spliceosome assembly protein PRP11" /calculated_mol_wt="29790" Region 1..262 /region_name="PRP11" /note="Splicing factor 3a, subunit 2 [RNA processing and modification]; COG5246" /db_xref="CDD:227571" CDS 1..266 /gene="PRP11" /locus_tag="YDL043C" /gene_synonym="RNA11" /coded_by="NM_001180102.1:1..801" /experiment="EXISTENCE:direct assay:GO:0000245 spliceosomal complex assembly [PMID:8969185]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8065365]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /note="Subunit of the SF3a splicing factor complex; required for spliceosome assembly" /db_xref="GeneID:851518" /db_xref="SGD:S000002201" ORIGIN 1 mnylegvgsk kggggiases qfnlqrrkev esllskgenv pytfqdekdd qvrsnpyiyk 61 nhsgklvckl cntmhmswss verhlggkkh glnvlrrgis ieksslgreg qtthdfrqqq 121 kiieakqslk nngtipvcki atvknpkngs vglaiqvnys sevkensvds ddkakvppli 181 rivsglelsd tkqkgkkflv iayepfenia ielppneilf senndmdnnn dgvdelnkkc 241 tfwdaiskly yvqfffkqae qeqadv // LOCUS NP_010242 562 aa linear PLN 30-JUN-2025 DEFINITION NAD-dependent histone deacetylase SIR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010242 VERSION NP_010242.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180101.1 REFERENCE 1 (residues 1 to 562) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 562) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 562) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 562) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11814. Method: conceptual translation. FEATURES Location/Qualifiers source 1..562 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..562 /product="NAD-dependent histone deacetylase SIR2" /EC_number="2.3.1.286" /calculated_mol_wt="63131" Region 104..261 /region_name="DUF592" /note="Protein of unknown function (DUF592); pfam04574" /db_xref="CDD:368003" Region 255..517 /region_name="SIRT1" /note="Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408" /db_xref="CDD:238699" Site order(264,266..267,274..275,326,344..345,347,364,471,476, 497..498,512) /site_type="other" /note="NAD+ binding site [chemical binding]" /db_xref="CDD:238699" Site order(346,364,443,445..449,475..477) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238699" Site order(372,375,396,399) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:238699" CDS 1..562 /gene="SIR2" /locus_tag="YDL042C" /gene_synonym="MAR1" /coded_by="NM_001180101.1:1..1689" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:9710643]" /experiment="EXISTENCE:direct assay:GO:0000792 heterochromatin [PMID:20176978]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:29795547]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005677 chromatin silencing complex [PMID:9122169]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9214640]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:11553718]" /experiment="EXISTENCE:direct assay:GO:0017136 histone deacetylase activity, NAD-dependent [PMID:10811920]" /experiment="EXISTENCE:direct assay:GO:0030869 RENT complex [PMID:10219244]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:19217406]" /experiment="EXISTENCE:direct assay:GO:0032041 histone H3K14 deacetylase activity, NAD-dependent [PMID:10693811]" /experiment="EXISTENCE:direct assay:GO:0046969 histone H3K9 deacetylase activity, NAD-dependent [PMID:10693811]" /experiment="EXISTENCE:direct assay:GO:0046970 histone H4K16 deacetylase activity, NAD-dependent [PMID:10693811]" /experiment="EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:26951198]" /experiment="EXISTENCE:genetic interaction:GO:0045910 negative regulation of DNA recombination [PMID:16182251]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:2647300]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:27122604]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:27185881]" /experiment="EXISTENCE:mutant phenotype:GO:0008156 negative regulation of DNA replication [PMID:15082529]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:3297920|PMID:11950950]" /experiment="EXISTENCE:mutant phenotype:GO:0031494 regulation of mating type switching [PMID:31461456]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11950950|PMID:9501103|PMID:1913809]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:27122604]" /experiment="EXISTENCE:mutant phenotype:GO:0045910 negative regulation of DNA recombination [PMID:25822194]" /experiment="EXISTENCE:mutant phenotype:GO:0097695 establishment of protein-containing complex localization to telomere [PMID:26218225]" /experiment="EXISTENCE:mutant phenotype:GO:0097752 regulation of DNA stability [PMID:27820830]" /experiment="EXISTENCE:mutant phenotype:GO:1904524 negative regulation of DNA amplification [PMID:26195783]" /note="Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication, suppressing early firing of multicopy rDNA origins; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy" /db_xref="GeneID:851520" /db_xref="SGD:S000002200" ORIGIN 1 mtiphmkyav sktsenkvsn tvsptqdkda irkqpddiin ndepshkkik vaqpdslret 61 nttdplghtk aalgevasme lkptndmdpl avsaasvvsm sndvlkpetp kgpiiisknp 121 sngifygpsf tkreslnarm flkyygahkf ldtylpedln slyiyylikl lgfevkdqal 181 igtinsivhi nsqervqdlg saisvtnved plakkqtvrl ikdlqraink vlctrlrlsn 241 fftidhfiqk lhtarkilvl tgagvstslg ipdfrssegf yskikhlgld dpqdvfnyni 301 fmhdpsvfyn ianmvlppek iysplhsfik mlqmkgkllr nytqnidnle syagistdkl 361 vqchgsfata tcvtchwnlp gerifnkirn lelplcpycy kkrreyfpeg ynnkvgvaas 421 qgsmserppy ilnsygvlkp ditffgealp nkfhksired ilecdllici gtslkvapvs 481 eivnmvpshv pqvlinrdpv khaefdlsll gycddiaamv aqkcgwtiph kkwndlknkn 541 fkcqekdkgv yvvtsdehpk tl // LOCUS NP_010244 854 aa linear PLN 30-JUN-2025 DEFINITION peptide alpha-N-acetyltransferase complex A subunit NAT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010244 VERSION NP_010244.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180099.1 REFERENCE 1 (residues 1 to 854) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 854) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 854) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 854) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11815. Method: conceptual translation. FEATURES Location/Qualifiers source 1..854 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..854 /product="peptide alpha-N-acetyltransferase complex A subunit NAT1" /calculated_mol_wt="98775" Region 23..303 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Site order(24..25,28..29,31,55,58..59,62..63,65..66,92,95..96, 99..100,103) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 24..48 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 53..83 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 91..118 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 199..736 /region_name="NatA_aux_su" /note="N-terminal acetyltransferase A, auxiliary subunit; pfam12569" /db_xref="CDD:463630" CDS 1..854 /gene="NAT1" /locus_tag="YDL040C" /gene_synonym="AAA1; NAA15" /coded_by="NM_001180099.1:1..2565" /experiment="EXISTENCE:direct assay:GO:0004596 protein-N-terminal amino-acid acetyltransferase activity [PMID:2551674]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006474 N-terminal protein amino acid acetylation [PMID:2551674]" /experiment="EXISTENCE:direct assay:GO:0031415 NatA complex [PMID:14517307]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:14517307]" /experiment="EXISTENCE:mutant phenotype:GO:0004596 protein-N-terminal amino-acid acetyltransferase activity [PMID:2551674]" /experiment="EXISTENCE:mutant phenotype:GO:0006474 N-terminal protein amino acid acetylation [PMID:2551674]" /note="Subunit of protein N-terminal acetyltransferase NatA; NatA comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins to influence multiple processes such as cell cycle progression, heat-shock resistance, mating, sporulation, telomeric silencing and early stages of mitophagy; orthologous to human NAA15; expression of both human NAA10 and NAA15 functionally complements ard1 nat1 double mutant although single mutations are not complemented by their orthologs" /db_xref="GeneID:851521" /db_xref="SGD:S000002198" ORIGIN 1 msrkrstkpk paakialkke ndqflealkl yegkqykksl klldailkkd gshvdslalk 61 gldlysvgek ddaasyvana irkiegasas picchvlgiy mrntkeykes ikwftaalnn 121 gstnkqiyrd latlqsqigd fknalvsrkk yweaflgyra nwtslavaqd vngerqqain 181 tlsqfeklae gkisdsekye hseclmyknd imykaasdnq dklqnvlkhl ndiepcvfdk 241 fgllerkati ymklgqlkda sivyrtlikr npdnfkyykl levslgiqgd nklkkalygk 301 leqfyprcep pkfipltflq dkeelskklr eyvlpqlerg vpatfsnvkp lyqrrkskvs 361 pllekivldy lsgldptqdp ipfiwtnyyl sqhflflkdf pkaqeyidaa ldhtptlvef 421 yilkarilkh lglmdtaagi leegrqldlq drfincktvk yflrannidk avevaslftk 481 nddsvngikd lhlveaswfi veqaeayyrl yldrkkkldd laslkkeves dkseqiandi 541 kenqwlvrky kglalkrfna ipkfykqfed dqldfhsycm rkgtprayle mlewgkalyt 601 kpmyvramke asklyfqmhd drlkrksdsl densdeiqnn gqnsssqkkk akkeaaamnk 661 rketeaksva aypsdqdndv fgeklietst pmedfatefy nnysmqvred erdyildfef 721 nyrigklalc faslnkfakr fgttsglfgs maivllhatr ndtpfdpilk kvvtksleke 781 ysenfplnei snnsfdwlnf yqekfgkndi ngllflyryr ddvpigssnl kemiisslsp 841 lephsqneil qyyl // LOCUS NP_010245 698 aa linear PLN 30-JUN-2025 DEFINITION pheromone-regulated protein PRM7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010245 VERSION NP_010245.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180098.1 REFERENCE 1 (residues 1 to 698) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 698) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 698) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 698) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11816. On Nov 27, 2009 this sequence version replaced NP_010245.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..698 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..698 /product="pheromone-regulated protein PRM7" /calculated_mol_wt="69993" Region 22..>643 /region_name="FhaB" /note="Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]; COG3210" /db_xref="CDD:442443" CDS 1..698 /gene="PRM7" /locus_tag="YDL039C" /gene_synonym="YDL038C" /coded_by="NM_001180098.1:1..2097" /note="Pheromone-regulated protein; predicted to have one transmembrane segment; promoter contains Gcn4p binding elements; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the IMI1" /db_xref="GeneID:851522" /db_xref="SGD:S000002197" ORIGIN 1 myrtrssdev ttstdltsss dvatsvdptt svisstsadp ttsadsttst vqttsagpsn 61 nignstlans ttfavsstsi dptsssdvit stvqttsiep ttslvssndi ttstslnisv 121 viststdsts liestttvgp hasssvagmy rtrssdevtt stdptsssdv atsadptsss 181 avttlvdptt svvistsvdq tsssdvatsv dpttsvisst sadpttsads ttstvqttsv 241 dptssvvssa pvdpassvvs ltssyptsss tvtisansng satlaaqtts idpvssivss 301 sgattiissa sidpassvvs stsseptsfi vsstsvystr psgpttstdl atfsdtiilr 361 vsttstsqdt qtvsssltdm vsstgsadls vssiqrsqvd pstfavsnsp vyptastgst 421 stgipiases lslsrqqgis atssssivtl tpvdsasssr ssatsiikpn mpvssndskt 481 qssvsvvdaf qstkssypsi tsadpttlas englvgssss ahpitldrty asahasvtdi 541 vsrvtdstrh ttlvtsnini qsevgnpnys gpkdttitkq safmtspast stisnvqsta 601 svmnhsiedn isaaaslesv sgtstkdyss qssaihytns ftttttnafi tskhsiaavs 661 tgaitssasi slimegsani eavgklvwla aalplafi // LOCUS NP_010247 328 aa linear PLN 30-JUN-2025 DEFINITION Bsc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010247 VERSION NP_010247.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180096.1 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11817. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..328 /product="Bsc1p" /calculated_mol_wt="34665" Region 4..141 /region_name="Flo11" /note="Flo11 domain; pfam10182" /db_xref="CDD:401990" CDS 1..328 /gene="BSC1" /locus_tag="YDL037C" /coded_by="NM_001180096.1:1..987" /note="Protein of unconfirmed function; similar to cell surface flocculin Flo11p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; in W303 strain one continuous open reading frame comprising of YDL037C, the intergenic region and YDL039C encodes the gene IMI1" /db_xref="GeneID:851524" /db_xref="SGD:S000002195" ORIGIN 1 msqqnilhyd mdvtsvswvk dntyqitihv kavkdiplky lwslkiigvn gpsstvqlyg 61 knektylisd ptdftstfqv yaypssdgct vwmpnfqiqf eylqgdaaqy wqtwqwgttt 121 fdlstgcnny dnqghsqtdf pgfywtyqck gnndgtctka ssssittssi ttsstttsst 181 ttsstttsss ttsssttsss ttsssttsss ttsssttsss ttsssttsss ttsssttsss 241 ttssstktst ttsstvksss ttsidfttsv dshtsssvad iyrsrtstdv ttlaastspf 301 ssftssdsss ssdvtsstiq ttsvdptt // LOCUS NP_010248 462 aa linear PLN 30-JUN-2025 DEFINITION pseudouridine synthase PUS9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010248 VERSION NP_010248.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180095.1 REFERENCE 1 (residues 1 to 462) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 462) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 462) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 462) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11818. Method: conceptual translation. FEATURES Location/Qualifiers source 1..462 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..462 /product="pseudouridine synthase PUS9" /EC_number="5.4.99.28" /calculated_mol_wt="53268" Region 121..433 /region_name="rluA_subfam" /note="pseudouridine synthase, RluA family; TIGR00005" /db_xref="CDD:161659" CDS 1..462 /gene="PUS9" /locus_tag="YDL036C" /coded_by="NM_001180095.1:1..1389" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:15466869]" /experiment="EXISTENCE:direct assay:GO:0031119 tRNA pseudouridine synthesis [PMID:15466869]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:15466869]" /experiment="EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:15466869]" /experiment="EXISTENCE:mutant phenotype:GO:0031119 tRNA pseudouridine synthesis [PMID:15466869]" /note="Mitochondrial tRNA:pseudouridine synthase; catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence; PUS9 has a paralog, RIB2, that arose from the whole genome duplication" /db_xref="GeneID:851525" /db_xref="SGD:S000002194" ORIGIN 1 mqrnnrlrnl ftvpvimarq lkrnalsagl afagnatsne fdehlqneve rereiqkkkk 61 ikrtqskksp dlinkstfqs rtigskkekh rqldpeyeiv idgplrkikp yhftyrtfck 121 erwrdkklvd vfisefrdre seyykrtien gdvhindeta dlstvirngd lithqvhrhe 181 ppvtsrpikv ifeddnimvi dkpsgipvhp tgryrfntit kmlqnnlgfv vnpcnrldrl 241 tsglmflakt pkgadnigdq lkarevtkey vakvvgefpe tevivekplk lieprlalna 301 vcqmdekgak haktvfnris ydgktsivkc kpltgrshqi rvhlqylghp iandpiysnd 361 evwgnnlgkg gqadfdivit kldeigkrkp akswfhsngg ygevlrqekc sicesdlytd 421 pgpndldlwl haylyestet eegtekkkwc ykteypewal rr // LOCUS NP_010249 961 aa linear PLN 30-JUN-2025 DEFINITION Gpr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010249 VERSION NP_010249.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180094.1 REFERENCE 1 (residues 1 to 961) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 961) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 961) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 961) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 961) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 961) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 961) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 961) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 961) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11819. Method: conceptual translation. FEATURES Location/Qualifiers source 1..961 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..961 /product="Gpr1p" /calculated_mol_wt="110579" Region 52..279 /region_name="Git3" /note="G protein-coupled glucose receptor regulating Gpa2; pfam11710" /db_xref="CDD:371685" Region 85..106 /region_name="TM helix 2" /note="TM helix 2 [structural motif]" /db_xref="CDD:320094" Region 127..149 /region_name="TM helix 3" /note="TM helix 3 [structural motif]" /db_xref="CDD:320094" Region 180..196 /region_name="TM helix 4" /note="TM helix 4 [structural motif]" /db_xref="CDD:320094" Region 239..264 /region_name="TM helix 5" /note="TM helix 5 [structural motif]" /db_xref="CDD:320094" Region 610..685 /region_name="GPR_Gpa2_C" /note="G protein-coupled glucose receptor regulating Gpa2 C-term; pfam11970" /db_xref="CDD:371826" CDS 1..961 /gene="GPR1" /locus_tag="YDL035C" /coded_by="NM_001180094.1:1..2886" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9524122|PMID:9388468|PMID:10655215]" /experiment="EXISTENCE:genetic interaction:GO:0009757 hexose mediated signaling [PMID:9813141]" /experiment="EXISTENCE:genetic interaction:GO:0010255 glucose mediated signaling pathway [PMID:10361302]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0004930 G protein-coupled receptor activity [PMID:9524122]" /experiment="EXISTENCE:mutant phenotype:GO:0005536 D-glucose binding [PMID:15494315]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:10655215]" /experiment="EXISTENCE:mutant phenotype:GO:0007186 G protein-coupled receptor signaling pathway [PMID:9524122]" /experiment="EXISTENCE:mutant phenotype:GO:0009731 detection of sucrose stimulus [PMID:15494315]" /experiment="EXISTENCE:mutant phenotype:GO:0009745 sucrose mediated signaling [PMID:15494315]" /experiment="EXISTENCE:mutant phenotype:GO:0009757 hexose mediated signaling [PMID:10655215|PMID:9813141]" /experiment="EXISTENCE:mutant phenotype:GO:0010255 glucose mediated signaling pathway [PMID:10361302|PMID:15494315|PMID:9813141]" /experiment="EXISTENCE:physical interaction:GO:0004930 G protein-coupled receptor activity [PMID:9388468|PMID:9524122]" /experiment="EXISTENCE:physical interaction:GO:0007186 G protein-coupled receptor signaling pathway [PMID:9388468|PMID:9524122]" /note="Plasma membrane G protein coupled receptor (GPCR); interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis" /db_xref="GeneID:851527" /db_xref="SGD:S000002193" ORIGIN 1 mitegfppnl nalkgsslle krvdslrqln tttvnqllgl pgmtstftap qllqlriiai 61 tasavsliag clgmfflskm dkrrkvfrhd liafliicdf lkafilmiyp miilinnsvy 121 atpaffntlg wftafaiega dmaimifaih failifkpnw kwrnkrsgnm egglykkrsy 181 iwpitalvpa ilaslafiny nklnddsdtt iildnnnynf pdsprqggyk pwsawcylpp 241 kpywykivls wgpryfiiif ifavylsiyi fitseskrik aqigdfnhnv leeekekkkl 301 fglghwgkak wyfrsyfklp llhllrnlkn fftisfidpn eetddsgssn gtfnfgessn 361 eiptlfrktn tgsdenvsas ggvrlldyns akpldmskya mseqpdlern npfdcendit 421 lnpselvskq kehkvtfsve negldtrkss mlghqtfscq nslesplamy dnkndnsdit 481 snikekggii nnnsnndddd nnnnndndnd nnnsnnnnnn nnnnnnnnnn nnnnnnnnnn 541 nnnnsnnikn nvdnnntnpa dniptlsnea ftpsqqfsqe rvnnnadrce nssftnvqqh 601 fqaqtykqmk krraqiqknl raifiyplsy igiwlfpiia dalqynheik hgptmwvtyi 661 dtcvrplscl vdvivylfke kpwnyswakt eskyliekyi lkgelgekei lkfchsnwgk 721 rgwyyrgkwk krkcwkystn plkrilwfve rffkqlfelk lhfsfydncd dfeywenyys 781 akdsndnkrt esdetktnss drslpsnsle lqamlnnita eevevplfwr iihhipmlgg 841 idldelnrll kirynndhfs lpglkfalnq nkshdkhqdv stnsmvkssf fssnivtndd 901 ensieedknl rysdasasen ylvkptipgt tpdpiieaqn dndssdssgi dliaflrngp 961 l // LOCUS NP_010251 417 aa linear PLN 30-JUN-2025 DEFINITION tRNA-5-taurinomethyluridine 2-sulfurtransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010251 VERSION NP_010251.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180092.1 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11820. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..417 /product="tRNA-5-taurinomethyluridine 2-sulfurtransferase" /EC_number="2.8.1.14" /calculated_mol_wt="46918" Region 27..407 /region_name="trmU" /note="tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; TIGR00420" /db_xref="CDD:273069" CDS 1..417 /gene="SLM3" /locus_tag="YDL033C" /gene_synonym="MTO2; MTU1" /coded_by="NM_001180092.1:1..1254" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:15944150]" /experiment="EXISTENCE:mutant phenotype:GO:0061708 tRNA-5-taurinomethyluridine 2-sulfurtransferase [PMID:15509579]" /experiment="EXISTENCE:mutant phenotype:GO:1990799 mitochondrial tRNA wobble position uridine thiolation [PMID:15509579]" /note="tRNA-specific 2-thiouridylase; responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human homolog TRMU is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF), and can complement yeast null mutant" /db_xref="GeneID:851529" /db_xref="SGD:S000002191" ORIGIN 1 mlarylnlig rrsaspyrpq rlpakfdnvi vamssgvdss vaaalfagef pntrgvymqn 61 wsesqslddp gkepcyerdw rdvnrvakhl nirvdkvnfe qdywidvfep mlrgysegst 121 pnpdigcnkf vkfgklrewl dekygtgnyw lvtghyarvm qemngkglfh llrsiyrpkd 181 qsyylsqins tvlsslllpi ghltkpevrd lakyaglpta ekpdsqgicf vnnsqhgkfk 241 nflkhylpss pgdiitvdpq sgakttwgrh dglwsytigq kvgismpqad pnyqgtwfvs 301 eklrdtneil ivrgrdnpal ysdtmrienf sslgpredti nafqntgalt lqfrslqvpv 361 qikscklnrs adnlditihl askqraitpg qscclyiddr vlgsgpishv nnndtha // LOCUS NP_010253 995 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase DBP10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010253 VERSION NP_010253.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180090.2 REFERENCE 1 (residues 1 to 995) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 995) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 995) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 995) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 995) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 995) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 995) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 995) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 995) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11821. On Apr 26, 2011 this sequence version replaced NP_010253.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..995 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..995 /product="ATP-dependent RNA helicase DBP10" /EC_number="3.6.4.13" /calculated_mol_wt="112816" Region 137..341 /region_name="DEADc_DDX54" /note="DEAD-box helicase domain of DEAD box protein 54; cd17959" /db_xref="CDD:350717" Region 138..555 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" Site order(156..157,159..161,164,182..189) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350717" Region 820..880 /region_name="DBP10CT" /note="DBP10CT (NUC160) domain; pfam08147" /db_xref="CDD:462373" CDS 1..995 /gene="DBP10" /locus_tag="YDL031W" /coded_by="NM_001180090.2:1..2988" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10871363]" /experiment="EXISTENCE:genetic interaction:GO:0030687 preribosome, large subunit precursor [PMID:16803892]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10871363]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10871363]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]" /experiment="EXISTENCE:physical interaction:GO:0030687 preribosome, large subunit precursor [PMID:16095611|PMID:16803892]" /note="Putative ATP-dependent RNA helicase of the DEAD-box protein family; constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis" /db_xref="GeneID:851530" /db_xref="SGD:S000002189" ORIGIN 1 magvqkrkrd ledqddngse eddiafdian eialndsesd andsdsevea dygpndvqdv 61 ieyssdeeeg vnnkkkaenk dikkkknskk eiaafpmlem sddennasgk tqtgddeddv 121 neyfstnnle ktkhkkgsfp sfglskivln nikrkgfrqp tpiqrktipl ilqsrdivgm 181 artgsgktaa filpmveklk shsgkigara vilspsrela mqtfnvfkdf argtelrsvl 241 ltggdsleeq fgmmmtnpdv iiatpgrflh lkvemnldlk sveyvvfdea drlfemgfqe 301 qlnellaslp ttrqtllfsa tlpnslvdfv kaglvnpvlv rldaetkvse nlemlflssk 361 nadreanlly ilqeiikipl atseqlqklq nsnneadsds ddendrqkkr rnfkkekfrk 421 qkmpaanelp sekatilfvp trhhveyisq llrdcgylis yiygtldqha rkrqlynfra 481 gltsilvvtd vaargvdipm lanvinytlp gsskifvhrv grtaragnkg waysivaene 541 lpylldlelf lgkkilltpm ydslvdvmkk rwidegkpey qfqppklsyt krlvlgscpr 601 ldveglgdly knlmssnfdl qlakktamka eklyyrtrts aspeslkrsk eiissgwdaq 661 naffgkneek ekldflaklq nrrnketvfe ftrnpddema vfmkrrrkql apiqrkater 721 rellekerma glshsiedei lkgddgetgy tvsedalkef edadqlleaq enenkkkkkp 781 ksfkdptffl shyapagdiq dkqlqitngf andaaqaayd lnsddkvqvh kqtatvkwdk 841 krkkyvntqg idnkkyiige sgqkiaasfr sgrfddwska rnlkplkvgs retsipsnll 901 edpsqgpaan grtvrgkfkh kqmkapkmpd khrdnyysqk kkvekalqsg isvkgynnap 961 glrselkste qirkdriiae kkraknarps kkrkf // LOCUS NP_010254 530 aa linear PLN 30-JUN-2025 DEFINITION SF3a splicing factor complex subunit PRP9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010254 VERSION NP_010254.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180089.1 REFERENCE 1 (residues 1 to 530) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 530) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 530) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 530) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11822. Method: conceptual translation. FEATURES Location/Qualifiers source 1..530 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..530 /product="SF3a splicing factor complex subunit PRP9" /calculated_mol_wt="62899" Region 1..530 /region_name="PRP9" /note="Splicing factor 3a, subunit 3 [RNA processing and modification]; COG5188" /db_xref="CDD:227515" Region 282..304 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275371" CDS 1..530 /gene="PRP9" /locus_tag="YDL030W" /coded_by="NM_001180089.1:1..1593" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:8969185]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8065365]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /note="Subunit of the SF3a splicing factor complex; required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex" /db_xref="GeneID:851531" /db_xref="SGD:S000002188" ORIGIN 1 mnlletrrsl leemeiiena iaeriqrnpe lyyhyiqess kvfpdtklpr ssliaenkiy 61 kfkkvkrkrk qiilqqhein iflrdyqekq qtfnkinrpe etqeddkdlp nferklqqle 121 kelknedenf eldinskkdk yalfssssdp srrtnilsdr ardldlneif trdeqygeym 181 eleqfhslwl nvikrgdcsl lqfldilelf lddekylltp pmdrkndrym afllklskyv 241 etfffksyal ldaaavenli ksdfehsycr gslrseakgi ycpfcsrwfk tssvfeshlv 301 gkihkknesk rrnfvyseyk lhrylkylnd efsrtrsfve rklaftaner maemdiltqk 361 yeapaydste kegaeqvdge qrdgqlqeeh lsgksfdmpl gpdglpmpyw lyklhgldre 421 yrceicsnkv yngrrtferh fneerhiyhl rclgiepssv fkgitkikea qelwknmqgq 481 sqltsiaavp pkpnpsqlkv pteleleeed eegnvmskkv ydelkkqglv // LOCUS NP_010255 391 aa linear PLN 30-JUN-2025 DEFINITION actin-related protein 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010255 VERSION NP_010255.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180088.1 REFERENCE 1 (residues 1 to 391) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 391) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 391) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 391) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11823. Method: conceptual translation. FEATURES Location/Qualifiers source 1..391 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..391 /product="actin-related protein 2" /calculated_mol_wt="43943" Region 5..387 /region_name="ASKHA_NBD_Arp2" /note="nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; cd10220" /db_xref="CDD:466821" CDS 1..391 /gene="ARP2" /locus_tag="YDL029W" /gene_synonym="ACT2" /coded_by="NM_001180088.1:1..1176" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:15657399]" /experiment="EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:11248049]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:15657399]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:16862144]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:17118118]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:18287533]" /experiment="EXISTENCE:mutant phenotype:GO:0034314 Arp2/3 complex-mediated actin nucleation [PMID:16862144]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0051654 establishment of mitochondrion localization [PMID:16107558]" /note="Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity; required for efficient Golgi-to-ER trafficking in COPI mutants" /db_xref="GeneID:851532" /db_xref="SGD:S000002187" ORIGIN 1 mdphnpivld qgtgfvkigr agenfpdytf psivgrpilr aeerasvatp lkdimigdea 61 sevrsylqis ypmengiikn wtdmellwdy affeqmklps tsngkillte ppmnplknre 121 kmcevmfeky dfggvyvaiq avlalyaqgl ssgvvvdsgd gvthivpvye svvlshltrr 181 ldvagrdvtr hlidllsrrg yafnrtadfe tvrqikeklc yvsydldldt klarettalv 241 esyelpdgrt ikvgqerfea peclfqpglv dveqpgvgel lfntvqsadv dirsslykai 301 vlsggssmyp glpsrlekel kqlwfsrvlh ndpsrldkfk vriedpprrk hmvfiggavl 361 asimadkdhm wlskqewqes gpsamtkfgp r // LOCUS NP_010256 764 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine/tyrosine protein kinase MPS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010256 VERSION NP_010256.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180087.2 REFERENCE 1 (residues 1 to 764) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 764) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 764) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 764) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11824. On Apr 26, 2011 this sequence version replaced NP_010256.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..764 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..764 /product="serine/threonine/tyrosine protein kinase MPS1" /EC_number="2.7.12.2" /calculated_mol_wt="86641" Region 439..716 /region_name="PKc_Mps1" /note="Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK); cd14131" /db_xref="CDD:271033" Site order(446..450,454,466,468,500,516..519,522,524,563,565, 567..568,570,580,583,601..604) /site_type="active" /db_xref="CDD:271033" Site order(446..450,454,466,468,500,516..519,522,563,565, 567..568,570,580) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271033" Site order(450,522,524,563,565,567,583,601..604) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271033" Site order(452,468,470,483,486,514,579) /site_type="other" /note="secondary chemical binding site [chemical binding]" /db_xref="CDD:271033" Site 579..604 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271033" CDS 1..764 /gene="MPS1" /locus_tag="YDL028C" /gene_synonym="PAC8; RPK1" /coded_by="NM_001180087.2:1..2295" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11827982]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:8688079|PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:25382489|PMID:11278681]" /experiment="EXISTENCE:direct assay:GO:0004712 protein serine/threonine/tyrosine kinase activity [PMID:7737118]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:11827982]" /experiment="EXISTENCE:direct assay:GO:0043515 kinetochore binding [PMID:31405987]" /experiment="EXISTENCE:genetic interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:8688079|PMID:8567717]" /experiment="EXISTENCE:genetic interaction:GO:0034501 protein localization to kinetochore [PMID:24402315]" /experiment="EXISTENCE:genetic interaction:GO:0044779 meiotic spindle checkpoint signaling [PMID:37018287]" /experiment="EXISTENCE:mutant phenotype:GO:0004712 protein serine/threonine/tyrosine kinase activity [PMID:15668173]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:32307893|PMID:8567717]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:1869587]" /experiment="EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:18060784]" /experiment="EXISTENCE:mutant phenotype:GO:0051225 spindle assembly [PMID:15668173]" /experiment="EXISTENCE:mutant phenotype:GO:0051988 regulation of attachment of spindle microtubules to kinetochore [PMID:23334295]" /note="Dual-specificity kinase; required for SPB duplication and spindle checkpoint function in mitosis and meiosis; contributes to bi-orientation, promoting formation of force-generating kinetochore-microtubule attachments in meiosis I; autophosphorylation required for function; substrates include SPB proteins (Spc42p, Spc110p, Spc98p), mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p; substrate of APCC(Cdh1); detected in peroxisomes; similar to human Mps1p" /db_xref="GeneID:851533" /db_xref="SGD:S000002186" ORIGIN 1 mstnsfhdyv dlksrtntrq fsddeefttp pklsnfgsal lshtektsas eilsshnndk 61 ianrleemdr sssrshppps mgnltsghts tsshstlfgr ylrnnhqtsm ttmntsdiei 121 nvgnsldksf erirnlrqnm keditakyae rrskrflisn rttklgpakr amtltnifde 181 dvpnspnqpi naretvelpl edshqtnfke tkrntdydsi dfgdlnpiqy ikkhnlptsd 241 lplisqiyfd kqreenrqaa lrkhssrell yksrsssssl ssnnllankd nsitsnngsq 301 prrkvstgss sskssieirr alkenidtsn nsnfnspihk iykgisrnkd sdsekrevlr 361 nisinanhad nllqqenkrl krslddaitn eninsknlev fyhrpapkpp vtkkveivep 421 aksaslsnnr niitvndsqy ekiellgrgg ssrvykvkgs gnrvyalkrv sfdafddssi 481 dgfkgeiell eklkdqkrvi qlldyemgdg llylimecgd hdlsqilnqr sgmpldfnfv 541 rfytkemllc ikvvhdagiv hsdlkpanfv lvkgilkiid fgianavpeh tvniyretqi 601 gtpnymapea lvamnytqns enqhegnkwk vgrpsdmwsc gciiyqmiyg kppygsfqgq 661 nrllaimnpd vkipfpehts nnekipksai elmkaclyrn pdkrwtvdkv lsstflqpfm 721 isgsimedli rnavrygsek phisqddlnd vvdtvlrkfa dyki // LOCUS NP_010257 420 aa linear PLN 30-JUN-2025 DEFINITION Mrx9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010257 VERSION NP_010257.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180086.1 REFERENCE 1 (residues 1 to 420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 420) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11825. Method: conceptual translation. FEATURES Location/Qualifiers source 1..420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..420 /product="Mrx9p" /calculated_mol_wt="48181" CDS 1..420 /gene="MRX9" /locus_tag="YDL027C" /coded_by="NM_001180086.1:1..1263" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:35779633]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Mitochondrial inner membrane protein; high copy suppressor of ER stress-mediated cell death; overexpression increases O2 consumption, impairs processing of COB and COX1 RNAs encoding mitochondrial oxidative phosphorylation factors, and impacts the transition from fermentative to respiratory metabolism" /db_xref="GeneID:851535" /db_xref="SGD:S000002185" ORIGIN 1 mfkvpvglas rtrelmnsvt lnslnngkgf nmylpgilra fpkpvpsait spaipkyrge 61 sfqfrklsci ssnycstthq flsslkssts rlvgkrafhs srraeikfif sskspkngnk 121 pfvkvykvsp ffiifatasi ftfiltstiv viplifhfff pllimffffk qfkkwqknif 181 ykdvltslpk tklkitlptm rslqlqpmvq swkeissrmg ipnefakgln vdlvkqeetr 241 kqflsflqkr vlesftknel girsyflgds vekwikesyd leldidncrs elrkfqtfif 301 ssvryklyld smknlplnps kklegkkhia dvyviildes fpaimfngga yskadffkil 361 qesetsnssk tlntiiaiks vntllskhfv ittngdsgef fskyniskin dknteytlke // LOCUS NP_010259 620 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase RTK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010259 VERSION NP_010259.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180084.1 REFERENCE 1 (residues 1 to 620) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 620) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 620) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 620) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11826. Method: conceptual translation. FEATURES Location/Qualifiers source 1..620 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..620 /product="putative serine/threonine protein kinase RTK1" /EC_number="2.7.11.1" /calculated_mol_wt="69484" Region 308..575 /region_name="STKc_HAL4_like" /note="Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; cd13994" /db_xref="CDD:270896" Site order(308..312,316,328,330,370,386..389,392,394,430,432, 434..435,437,448,451,471..474) /site_type="active" /db_xref="CDD:270896" Site order(308..312,316,328,330,370,386..389,392,430,432, 434..435,437,448) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270896" Site order(312,392,394,430,432,434,451,471..474) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270896" Site order(447..455,459..464,468..474) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270896" CDS 1..620 /gene="RTK1" /locus_tag="YDL025C" /coded_by="NM_001180084.1:1..1863" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:23785265]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:23785265]" /note="Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851536" /db_xref="SGD:S000002183" ORIGIN 1 mvketplhss sstslsslfr ptklknlsak ifngggnqsy sktddvsrss srsskkntds 61 dqedqikynk pndrrstigk spqgngalsk eshvvasstl tgisptsakk apidyspsrp 121 lpnnhnpvrt ghtvphlphs ihnpinyihq gskdafhhph pvrstahsni stvssaksdt 181 pssnlsyqah mhpveilqkq iedkhfmdsq astpgsvelq hnsssgsddt ssrkkkslrl 241 trffkkihnd yhdnhhhhhh hnrgstptkp klnlntneni vesngkalye tdnpvellek 301 ygipgrklge gasgsvsvve rtdgklfack mfrkphlnne gtnqsqlany skkvttefci 361 gstlhheniv etldmltegd tyllvmeyap ydffnlvmsn lmtqdevncy fkqlchgvny 421 lhsmglahrd lkldncvvtk dgilklidfg savvfqypye dtivkshgiv gsdpylapel 481 lkqtsydprv advwsiaiif ycmvlkrfpw kapkksfnsf rlfteepede ddivrgpnki 541 lrllprhsrt iigrmlalep kqrvlmndvv kddwlvsvps cevdptsgdl vekpknhkhh 601 lvteeelnel tkqhgnkdsn // LOCUS NP_010260 468 aa linear PLN 30-JUN-2025 DEFINITION putative acid phosphatase DIA3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010260 VERSION NP_010260.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180083.1 REFERENCE 1 (residues 1 to 468) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 468) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 468) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 468) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11827. Method: conceptual translation. FEATURES Location/Qualifiers source 1..468 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..468 /product="putative acid phosphatase DIA3" /EC_number="3.1.3.2" /calculated_mol_wt="52946" Region 66..400 /region_name="His_Phos_2" /note="Histidine phosphatase superfamily (branch 2); pfam00328" /db_xref="CDD:395259" Site order(75..76,79,176,338..339) /site_type="active" /note="catalytic core [active]" /db_xref="CDD:132717" CDS 1..468 /gene="DIA3" /locus_tag="YDL024C" /coded_by="NM_001180083.1:1..1407" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:11063681]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:11063681]" /note="hypothetical protein; involved in invasive and pseudohyphal growth" /db_xref="GeneID:851537" /db_xref="SGD:S000002182" ORIGIN 1 mvkpvifaic lgvllskals iplrsfadie ligsqkslfp flggsapyfs fpanygiptd 61 ipegcrltqv qmigrhgery ptrseakdif evwykisnyt gkyegslsfl nngyeffipd 121 esllemettl qnsidvlnpy tgemnakrha reflakygkl menctnfpif ttnskriydt 181 aqyfaealgd gfnislqtls ensssgantl aaksscpnwn snanndilms ysrdylenis 241 drlndenkgl nlsrkdaaal fswcafelna kgysnicdif saaelihysy etdltsfyqn 301 gpgykliksi ganlfnatvk lirqsahldq kvwlsfthdt dilnylttag liddtrnltt 361 nhvpfrdhsy hrswyipqga rvytekfqcs ndsyvryvvn davvpiescs sgpgfsceeg 421 tfyeyakdrl rgvsfyedcd vskvskekel tfywdwnttr ynaslvnq // LOCUS NP_001257670 82 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL022C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257670 VERSION NP_001257670.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270741.1 REFERENCE 1 (residues 1 to 82) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 82) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 82) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 82) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35098. Method: conceptual translation. FEATURES Location/Qualifiers source 1..82 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..82 /product="uncharacterized protein" /calculated_mol_wt="9590" CDS 1..82 /locus_tag="YDL022C-A" /coded_by="NM_001270741.1:1..249" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR; mRNA identified as translated by ribosome profiling data" /db_xref="GeneID:13393611" /db_xref="SGD:S000028537" ORIGIN 1 myylvpktty gnlqcsslam tfhergesgd vlscacrlyl yimplffntf lrqkyfqlcs 61 ntpyrnngea ryfchlfrcs ii // LOCUS NP_010262 391 aa linear PLN 30-JUN-2025 DEFINITION glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010262 VERSION NP_010262.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180081.1 REFERENCE 1 (residues 1 to 391) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 391) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 391) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 391) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11828. Method: conceptual translation. FEATURES Location/Qualifiers source 1..391 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..391 /product="glycerol-3-phosphate dehydrogenase (NAD(+)) GPD1" /EC_number="1.1.1.8" /calculated_mol_wt="42738" Region 36..383 /region_name="glycerol3P_DH" /note="glycerol-3-phosphate dehydrogenase (NAD(+)); TIGR03376" /db_xref="CDD:274551" CDS 1..391 /gene="GPD1" /locus_tag="YDL022W" /gene_synonym="DAR1; HOR1; OSG1; OSR5" /coded_by="NM_001180081.1:1..1176" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20026609]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:15210723]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15210723]" /experiment="EXISTENCE:mutant phenotype:GO:0006973 intracellular accumulation of glycerol [PMID:8196651]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:26276932]" /experiment="EXISTENCE:mutant phenotype:GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [PMID:8196651]" /note="NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases Ypk1p and Ypk2p, dephosphorylation increases catalytic activity; forms a heterodimer with Pnc1p to facilitate its peroxisomal import" /db_xref="GeneID:851539" /db_xref="SGD:S000002180" ORIGIN 1 msaaadrlnl tsghlnagrk rssssvslka aekpfkvtvi gsgnwgttia kvvaenckgy 61 pevfapivqm wvfeeeinge klteiintrh qnvkylpgit lpdnlvanpd lidsvkdvdi 121 ivfniphqfl pricsqlkgh vdshvraisc lkgfevgakg vqllssyite elgiqcgals 181 ganiatevaq ehwsettvay hipkdfrgeg kdvdhkvlka lfhrpyfhvs viedvagisi 241 cgalknvval gcgfveglgw gnnasaaiqr vglgeiirfg qmffpesree tyyqesagva 301 dlittcaggr nvkvarlmat sgkdawecek ellngqsaqg litckevhew letcgsvedf 361 plfeavyqiv ynnypmknlp dmieeldlhe d // LOCUS NP_010263 311 aa linear PLN 30-JUN-2025 DEFINITION phosphoglycerate mutase family protein GPM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010263 VERSION NP_010263.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180080.1 REFERENCE 1 (residues 1 to 311) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 311) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 311) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 311) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11829. Method: conceptual translation. FEATURES Location/Qualifiers source 1..311 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..311 /product="phosphoglycerate mutase family protein GPM2" /EC_number="5.4.2.11" /calculated_mol_wt="35942" Region 10..292 /region_name="GpmA" /note="Phosphoglycerate mutase (BPG-dependent) [Carbohydrate transport and metabolism]; COG0588" /db_xref="CDD:440353" CDS 1..311 /gene="GPM2" /locus_tag="YDL021W" /coded_by="NM_001180080.1:1..936" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24146988|PMID:11914276]" /note="Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM2 has a paralog, GPM3, that arose from the whole genome duplication" /db_xref="GeneID:851541" /db_xref="SGD:S000002179" ORIGIN 1 mtastpsnvm tlfllrhgqs elnhenifcg widakltekg keqarhsael ieqyckannl 61 rlpqigytsr lirtqqtiet mceefklkpq lqvvydfnki klgdefgsdd kdnmkipilq 121 twrlnerhyg swqgqrkpnv lkeygkdkym firrdyegkp ppvdldremi qqenekgsst 181 gyefkepnrq ikyelecsnh divlpdsesl revvyrlnpf lqnvilklan qydesscliv 241 ghgssvrsll kilegisddd iknvdipngi plvveldknn glkfirkfyl dpesakinae 301 kvrnegfikn p // LOCUS NP_010264 531 aa linear PLN 30-JUN-2025 DEFINITION stress-regulated transcription factor RPN4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010264 VERSION NP_010264.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180079.3 REFERENCE 1 (residues 1 to 531) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 531) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 531) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 531) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 531) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 531) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 531) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 531) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 531) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11830. On Jul 30, 2012 this sequence version replaced NP_010264.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..531 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..531 /product="stress-regulated transcription factor RPN4" /calculated_mol_wt="60022" Region 450..468 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 477..504 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..531 /gene="RPN4" /locus_tag="YDL020C" /gene_synonym="SON1; UFD5" /coded_by="NM_001180079.3:1..1596" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:10350051]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10350051]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:19914394|PMID:8514125]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:19914394|PMID:10350051]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15178333]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11027285|PMID:20376190]" /experiment="EXISTENCE:mutant phenotype:GO:0006282 regulation of DNA repair [PMID:11027285|PMID:20376190]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:18627600|PMID:11027285|PMID:18086556|PMID:16556235]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11027285|PMID:16556235|PMID:27226598|PMID:19914394|P MID:15575969|PMID:18627600|PMID:18804109|PMID:11248031|PMI D:10350051|PMID:18086556|PMID:15178333]" /experiment="EXISTENCE:mutant phenotype:GO:0071243 cellular response to arsenic-containing substance [PMID:15575969|PMID:27226598]" /note="Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:851542" /db_xref="SGD:S000002178" ORIGIN 1 mastelslkr tltdiledel yhtnpghsqf tshyqnyhpn asitpyklvn knkenntftw 61 nhslqhqnes saasippqqt yhfpifnkya dptlttttsf ttseatandr qinnvhlipn 121 eikgasetpl qktvnlknim kvsdpyvptr ntfnydvkis ndffdngdnl ygndeevlfy 181 ednynpkmqw slqdnsaain nedaraifnn efdsddddis ddeedeieen clqqeqhqee 241 pllsldvtpi smfgsdqktg rakssshlfn eysyvdsnmd sissvvsedl lderghekie 301 dededndlde ddiydisllk nrrkqsfvln kntidferfp spstsanvps tattgkrkpa 361 ksssnrscvs nsnengtler ikkptsavvs snasrrklin ytkkhlsshs stnsnskpst 421 aspsahtsss dgnneiftcq imnlitnepc gaqfsrsydl trhqntihak rkivfrcsec 481 ikilgsegyq ktfsrldalt rhikskhedl sleqrqevtk fakanigyvm g // LOCUS NP_010265 1283 aa linear PLN 30-JUN-2025 DEFINITION oxysterol-binding protein related protein OSH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010265 VERSION NP_010265.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180078.1 REFERENCE 1 (residues 1 to 1283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1283) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11831. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1283 /product="oxysterol-binding protein related protein OSH2" /calculated_mol_wt="145665" Region 59..127 /region_name="Ank_4" /note="Ankyrin repeats (many copies); pfam13637" /db_xref="CDD:372654" Region 60..104 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(61..62,65..67,69..70,74,77,104,106,108,112..113, 116..118,120..121,125,128,137,139,141..143,145..146,150) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region <99..>246 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 106..137 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 289..391 /region_name="PH_Osh1p_Osh2p_yeast" /note="Yeast oxysterol binding protein homologs 1 and 2 Pleckstrin homology (PH) domain; cd13292" /db_xref="CDD:241446" Region 897..1271 /region_name="Oxysterol_BP" /note="Oxysterol-binding protein; pfam01237" /db_xref="CDD:460126" CDS 1..1283 /gene="OSH2" /locus_tag="YDL019C" /coded_by="NM_001180078.1:1..3852" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:25420878]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12727870]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25420878|PMID:11408574]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11408574]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:20008566]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:16585271]" /experiment="EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:24213531]" /note="Member of an oxysterol-binding protein family with seven members; in S. cerevisiae, family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane and at the nuclear envelope; regulated by sterol binding; OSH2 has a paralog, SWH1, that arose from the whole genome duplication" /db_xref="GeneID:851543" /db_xref="SGD:S000002177" ORIGIN 1 msredlsiae dlnqvskpll kvkllevlgq gdfkhlkalv dnefqpkddp svqqvlnlil 61 hyavqvapil likeivahwv dqvgdeksss ksddgihldl nyqdengntp lhlaaaqsrs 121 dvisfllsqk sindcvknka hqqpldmckd lnvaqmiqlk rddyfletvh slraamnkrd 181 fskldsiwkn prnlnlldin gidpetgttl lyeysqkkdi emcqwllkhg aeatvkdgkg 241 rspldlvkni klpakpsnnv tpeiklknll eknlreqaiv hedvasskpp tykgflkkwt 301 nfahgyklrw filsgdgnls yykdqshvdr prgtlkvstc rlhidssekl nfellggitg 361 ttrwrlkgnh piettrwvna iqsairfakd keilnkkkav ppslalknks palishsktq 421 gslpeasqyy qhtlhkeviq pssvslyrrp snnlsvvsse iqlndnltes gkrfvskmie 481 nrldgsktpv gvhtgsalqr vrssntlksn rsmqsgsgva spidkvpnga nlsqsntttg 541 staslsdnny idnfegdean sddeeedlgi nfdrdeeyik aqygpykekl dmyeqaisie 601 lsslielieq eepspevwlt ikkslintst ifgklkdlty krdkrlvdmv skqgdvnnvw 661 vqsvkeleme lsnkterlas idkerrglkk ilhkkllesh atagnkesle ndkeqesdtt 721 astlgqiakf isatkeedea sdadefydaa elvdevtelt eahpeistaa apkhapppvp 781 netdndsqyv qdekskiesn vektsqkfek qnnlvtedep ktdqslknfk aedkesqvke 841 ktkeiassvi gektivavtt vqkrkeeyll kegsylgyed girkrlsmdk ddrpkislwa 901 vlksmvgkdm trmtlpvtfn eptsllqrva edleyselld qaatfedstl rtlyvaafta 961 ssyasttkrv akpfnpllge tfeysrpdkq yrffteqvsh hppisatwte sprwdfwges 1021 fvdtkfngrs fnvkhlglwh iklrpndnek eelytwkkpn ntvigilign pqvdnhgevn 1081 vvnhttgdhc klyfkargwr ssgayeitge vynkkkqkvw ilgghwneai fakkvvkdgd 1141 lslektrtaa sagngptddg tkfliwkand rpeepfnltp faitlnapqp hllpwlpptd 1201 trlrpdqram edgrydeagd ekfrveekqr aarrkreenn leyhpqwfvr dthpitkaky 1261 wrytgkywvk rrdhdlkdcg dif // LOCUS NP_010266 225 aa linear PLN 30-JUN-2025 DEFINITION Erp3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010266 VERSION NP_010266.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180077.1 REFERENCE 1 (residues 1 to 225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 225) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11832. Method: conceptual translation. FEATURES Location/Qualifiers source 1..225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..225 /product="Erp3p" /calculated_mol_wt="26380" Region 23..218 /region_name="EMP24_GP25L" /note="emp24/gp25L/p24 family/GOLD; pfam01105" /db_xref="CDD:426051" CDS 1..225 /gene="ERP3" /locus_tag="YDL018C" /coded_by="NM_001180077.1:1..678" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport" /db_xref="GeneID:851544" /db_xref="SGD:S000002176" ORIGIN 1 msnlcvlffq ffflaqffae aspltfelnk grkeclytlt peidctisyy favqqgesnd 61 fdvnyeifap ddknkpiier sgerqgewsf igqhkgeyai cfyggkahdk ivdldfkync 121 erqddirner rkarkaqrnl rdsktdplqd svensidtie rqlhvlerni qyyksrntrn 181 hhtvcstehr ivmfsiygil liigmscaqi ailefifres rkhnv // LOCUS NP_010267 507 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase CDC7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010267 VERSION NP_010267.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180076.3 REFERENCE 1 (residues 1 to 507) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 507) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 507) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 507) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11833. On Jul 30, 2012 this sequence version replaced NP_010267.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..507 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..507 /product="serine/threonine protein kinase CDC7" /EC_number="2.7.11.1" /calculated_mol_wt="58189" Region 31..348 /region_name="STKc_Cdc7" /note="Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; cd14019" /db_xref="CDD:270921" Site order(39..43,47,74,76,86,104,120..123,127,129..130,163,165, 167..168,170,182,185,276,278..281,283,322) /site_type="active" /db_xref="CDD:270921" Site order(39..42,45,47,74,76,104,120..123,125,167..168,170,182) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270921" Site order(86,129,163,165,185,276,278..281,283,322) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270921" Site order(181..191,271..283) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270921" Region <443..476 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" CDS 1..507 /gene="CDC7" /locus_tag="YDL017W" /gene_synonym="LSD6; SAS1" /coded_by="NM_001180076.3:1..1524" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23746350]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10508166]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:34432494|PMID:10508166|PMID:9407029|PMID:18245450|PM ID:10805723|PMID:23314252|PMID:19692334|PMID:25602519]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2023904]" /experiment="EXISTENCE:direct assay:GO:0031431 Dbf4-dependent protein kinase complex [PMID:19692334]" /experiment="EXISTENCE:direct assay:GO:1902977 mitotic DNA replication preinitiation complex assembly [PMID:21729781|PMID:26338774]" /experiment="EXISTENCE:direct assay:GO:1905342 positive regulation of protein localization to kinetochore [PMID:34432494]" /experiment="EXISTENCE:genetic interaction:GO:0031431 Dbf4-dependent protein kinase complex [PMID:8474449]" /experiment="EXISTENCE:genetic interaction:GO:0031503 protein-containing complex localization [PMID:19013276]" /experiment="EXISTENCE:genetic interaction:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:18372119]" /experiment="EXISTENCE:genetic interaction:GO:0060903 positive regulation of meiosis I [PMID:18245451]" /experiment="EXISTENCE:genetic interaction:GO:1904968 positive regulation of spindle attachment to meiosis I kinetochore [PMID:19013276]" /experiment="EXISTENCE:genetic interaction:GO:1905263 positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [PMID:19013276|PMID:18245451]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:10508166|PMID:18245450|PMID:10805723|PMID:2023904|PM ID:2166954]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:9472018]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:16319063]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:19013276]" /experiment="EXISTENCE:mutant phenotype:GO:1902977 mitotic DNA replication preinitiation complex assembly [PMID:21729781]" /experiment="EXISTENCE:mutant phenotype:GO:1904968 positive regulation of spindle attachment to meiosis I kinetochore [PMID:19013276]" /experiment="EXISTENCE:mutant phenotype:GO:1905263 positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [PMID:18245450]" /experiment="EXISTENCE:physical interaction:GO:0001100 negative regulation of exit from mitosis [PMID:19478884]" /experiment="EXISTENCE:physical interaction:GO:0031431 Dbf4-dependent protein kinase complex [PMID:8474449]" /note="S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase); required for origin firing and replication initiation; phosphorylates MCM subunits and Cdc45 to drive assembly of the pre-IC and the CMG helicase; maintains Cse4p at kinetochores through phosphorylation to regulate chromosome segregation, regulates pre-meiotic replication, meiotic DSB formation, monopolar attachment of homologs during MI through monopolin recruitment and middle meiotic gene expression; HsCDC7 and DBF4 complement" /db_xref="GeneID:851545" /db_xref="SGD:S000002175" ORIGIN 1 mtsktknidd ippeikeemi qlyhdlpgie neyklidkig egtfssvyka kditgkitkk 61 fashfwnygs nyvalkkiyv tsspqriyne lnllyimtgs srvaplcdak rvrdqviavl 121 pyypheefrt fyrdlpikgi kkyiwellra lkfvhskgii hrdikptnfl fnlelgrgvl 181 vdfglaeaqm dyksmissqn dydnyantnh dggysmrnhe qfcpcimrnq yspnshnqtp 241 pmvtiqngkv vhlnnvngvd ltkgypknet rrikranrag trgfrapevl mkcgaqstki 301 diwsvgvill sllgrrfpmf qslddadsll elctifgwke lrkcaalhgl gfeasgliwd 361 kpngysnglk efvydllnke ctigtfpeys vafetfgflq qelhdrmsie pqlpdpktnm 421 davdayelkk yqeeiwsdhy wcfqvleqcf emdpqkrssa edllktpffn elnentylld 481 gestdeddvv ssseadlldk dvllise // LOCUS NP_010269 310 aa linear PLN 30-JUN-2025 DEFINITION trans-2-enoyl-CoA reductase (NADPH) TSC13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010269 VERSION NP_010269.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180074.1 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11834. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..310 /product="trans-2-enoyl-CoA reductase (NADPH) TSC13" /EC_number="1.3.1.93" /calculated_mol_wt="36637" Region 1..297 /region_name="PLN02560" /note="enoyl-CoA reductase" /db_xref="CDD:178174" Region 154..310 /region_name="Steroid_dh" /note="3-oxo-5-alpha-steroid 4-dehydrogenase; pfam02544" /db_xref="CDD:460585" CDS 1..310 /gene="TSC13" /locus_tag="YDL015C" /coded_by="NM_001180074.1:1..933" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11113186]" /experiment="EXISTENCE:mutant phenotype:GO:0000038 very long-chain fatty acid metabolic process [PMID:11113186]" /experiment="EXISTENCE:mutant phenotype:GO:0016491 oxidoreductase activity [PMID:11113186]" /note="Enoyl reductase; catalyzes last step in each cycle of very long chain fatty acid elongation; localizes to ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Elo2p and Elo3p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress; human homolog TECR implicated in nonsyndromic mental retardation, can complement yeast mutant" /db_xref="GeneID:851547" /db_xref="SGD:S000002173" ORIGIN 1 mpitiksrsk glrdteidls kkptlddvlk kisannhnis kyrirltykk eskqvpvise 61 sffqeeadds meffikdlgp qiswrlvffc eylgpvlvhs lfyylstipt vvdrwhsass 121 dynpflnrva yflilghygk rlfetlfvhq fslatmpifn lfkncfhywv lsglisfgyf 181 gygfpfgnak lfkyysylkl ddlstliglf vlselwnfyc hiklrlwgdy qkkhgnakir 241 vplnqgifnl fvapnytfev wswiwftfvf kfnlfavlfl tvstaqmyaw aqkknkkyht 301 rraflipfvf // LOCUS NP_010270 327 aa linear PLN 30-JUN-2025 DEFINITION rRNA methyltransferase NOP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010270 VERSION NP_010270.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180073.1 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11835. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..327 /product="rRNA methyltransferase NOP1" /calculated_mol_wt="34334" Region 85..320 /region_name="PTZ00146" /note="fibrillarin; Provisional" /db_xref="CDD:240291" CDS 1..327 /gene="NOP1" /locus_tag="YDL014W" /gene_synonym="LOT3" /coded_by="NM_001180073.1:1..984" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11932453|PMID:2686980]" /experiment="EXISTENCE:direct assay:GO:0008649 rRNA methyltransferase activity [PMID:12215523]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:12215523]" /experiment="EXISTENCE:direct assay:GO:0031428 box C/D methylation guide snoRNP complex [PMID:11081632]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000494 box C/D sno(s)RNA 3'-end processing [PMID:15167896|PMID:10733567]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:1825809]" /experiment="EXISTENCE:mutant phenotype:GO:0008649 rRNA methyltransferase activity [PMID:12215523]" /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:12215523|PMID:8431947]" /experiment="EXISTENCE:mutant phenotype:GO:1990259 histone H2AQ104 methyltransferase activity [PMID:24352239]" /note="Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin; inviability of the null mutant is functionally complemented by human FBL" /db_xref="GeneID:851548" /db_xref="SGD:S000002172" ORIGIN 1 msfrpgsrgg srggsrggfg grggsrggar ggsrggfggr ggsrggargg srggfggrgg 61 srggarggsr ggrggaagga rggakvviep hrhagvyiar gkedllvtkn mapgesvyge 121 krisveepsk edgvpptkve yrvwnpfrsk laagimggld elfiapgkkv lylgaasgts 181 vshvsdvvgp egvvyavefs hrpgrelism akkrpniipi iedarhpqky rmligmvdcv 241 fadvaqpdqa riialnshmf lkdqggvvis ikancidstv daetvfarev qklreerikp 301 leqltlepye rdhcivvgry mrsglkk // LOCUS NP_010271 619 aa linear PLN 30-JUN-2025 DEFINITION SUMO-targeted ubiquitin ligase complex subunit SLX5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010271 VERSION NP_010271.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180072.3 REFERENCE 1 (residues 1 to 619) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 619) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 619) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 619) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11836. On Jul 30, 2012 this sequence version replaced NP_010271.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..619 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..619 /product="SUMO-targeted ubiquitin ligase complex subunit SLX5" /EC_number="2.3.2.27" /calculated_mol_wt="70940" Region 106..184 /region_name="DUF916" /note="Bacterial protein of unknown function (DUF916); pfam06030" /db_xref="CDD:461805" CDS 1..619 /gene="SLX5" /locus_tag="YDL013W" /gene_synonym="HEX3; ULS2" /coded_by="NM_001180072.3:1..1860" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23785440]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:18032921|PMID:17848550|PMID:17728242]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23785440|PMID:19270524]" /experiment="EXISTENCE:direct assay:GO:0032183 SUMO binding [PMID:17848550]" /experiment="EXISTENCE:direct assay:GO:0033768 SUMO-targeted ubiquitin ligase complex [PMID:17848550]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:11139495]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:16428246]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:26960795]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:31320817]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:11139495|PMID:16325482]" /experiment="EXISTENCE:physical interaction:GO:0032183 SUMO binding [PMID:17728242]" /note="Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex; role in Ub-mediated degradation of histone variant Cse4p preventing mislocalization to euchromatin; role in proteolysis of spindle positioning protein Kar9p, and DNA repair proteins Rad52p and Rad57p; forms SUMO-dependent nuclear foci, including DNA repair centers; contains a RING domain and two SIM motifs; associates with the centromere; required for maintenance of genome integrity like human ortholog RNF4" /db_xref="GeneID:851549" /db_xref="SGD:S000002171" ORIGIN 1 mhsdtngrtk snnspsdnnp netvilidsd keedasirea nlpvrlypdr rvgrrrdaln 61 rfvrsdsrsr nsqrthitas serpdfqann dditiirevg rffgddgpid psahyvdldq 121 epgsetletp rtiqvdntng ylndngnnne sddgltivee rttrprvtln lpggerlevt 181 atttdipirr sfefqedlga srrqllrrsa trarnlfvdr sdendedwtd dthnlpeaiq 241 rarresrmrm srriaerqrr vqqqrvssde nistsirlqs ireriqsytp dirsafhrae 301 slhefrsilq nvapitlqec eeelmalfte frnqllqnwa idrvrntqee alrlhreale 361 rqertagrvf hrgtlresit nylnfngedg flsrlwsgpa lsdadeerht qniidmiqer 421 eererdvvmk nlmnktraqq eefearaasl pegysasfdt tpkmklditk ngkeetiivt 481 dddlaktled ipvcclcgae lgvgipddft gisqkdrgvs feglvskykf hcpyqtlarp 541 smldrdlskr tfiascghaf cgrcfaridn akkkskmpkk klaqlkgsah pdnygpklcp 601 adsckklirs rgrlkevyf // LOCUS NP_010272 107 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL012C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010272 VERSION NP_010272.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180071.1 REFERENCE 1 (residues 1 to 107) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 107) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 107) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 107) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11837. Method: conceptual translation. FEATURES Location/Qualifiers source 1..107 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..107 /product="uncharacterized protein" /calculated_mol_wt="12044" Region 75..107 /region_name="CYSTM" /note="Cysteine-rich TM module stress tolerance; pfam12734" /db_xref="CDD:403822" CDS 1..107 /locus_tag="YDL012C" /coded_by="NM_001180071.1:1..324" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12514182]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication" /db_xref="GeneID:851550" /db_xref="SGD:S000002170" ORIGIN 1 msaqdyygns askqsysrps apppgyetas rgyapsqsqq nyyppqqqqq qyqqqpqyyq 61 qqqpqyyqqh pqqpiyvqqq passgnedcl agclaglclc ctldmlf // LOCUS NP_010274 231 aa linear PLN 30-JUN-2025 DEFINITION glutathione-disulfide reductase GRX6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010274 VERSION NP_010274.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180069.1 REFERENCE 1 (residues 1 to 231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 231) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11838. Method: conceptual translation. FEATURES Location/Qualifiers source 1..231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..231 /product="glutathione-disulfide reductase GRX6" /calculated_mol_wt="25652" Region 127..210 /region_name="GRX_GRXh_1_2_like" /note="Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase; cd03419" /db_xref="CDD:239511" Site order(133,136,138,181..184,195..198) /site_type="other" /note="GSH binding site [chemical binding]" /db_xref="CDD:239511" Site order(136,139) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239511" CDS 1..231 /gene="GRX6" /locus_tag="YDL010W" /coded_by="NM_001180069.1:1..696" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004362 glutathione-disulfide reductase (NADPH) activity [PMID:18400945]" /experiment="EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:18503006]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:18503006]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:18503006]" /experiment="EXISTENCE:direct assay:GO:0005796 Golgi lumen [PMID:18400945]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:18400945]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:18503006]" /experiment="EXISTENCE:direct assay:GO:0051537 2 iron, 2 sulfur cluster binding [PMID:18171082]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:18400945]" /experiment="EXISTENCE:mutant phenotype:GO:0004362 glutathione-disulfide reductase (NADPH) activity [PMID:18400945]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:18400945]" /note="Cis-Golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication" /db_xref="GeneID:851551" /db_xref="SGD:S000002168" ORIGIN 1 mipsnkrnar ilsittllll lvffvaqnan fltveikeet skafstnmdn maggssreya 61 amptsttnkg ssevdeeine ikqkvglqqp iasvddslsa ikndkgsrit kafnvqkeys 121 lildlspiii fskstcsysk gmkelleney qfipnyyiie ldkhghgeel qeyiklvtgr 181 gtvpnllvng vsrggneeik klhtqgklle slqvwsdgkf sveqrekpsn n // LOCUS NP_001257671 107 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL009C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257671 VERSION NP_001257671.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270742.1 REFERENCE 1 (residues 1 to 107) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 107) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 107) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 107) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35099. Method: conceptual translation. FEATURES Location/Qualifiers source 1..107 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..107 /product="uncharacterized protein" /calculated_mol_wt="12594" CDS 1..107 /locus_tag="YDL009C" /coded_by="NM_001270742.1:1..324" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; mRNA identified as translated by ribosome profiling data; SWAT-GFP and mCherry fusion proteins localize to the cytosol; partially overlaps the verified ORF YDL010W; YDL009C is not an essential gene" /db_xref="GeneID:851553" /db_xref="SGD:S000002167" ORIGIN 1 mkalsvlcfh npfkrclgqk sffvgdsffi ptpkrlvlgk lrlsnytafh dliihdlfiy 61 ifilnffffp fcnnfnywkv fhvaqpriyh hsrlvmilkv slecavs // LOCUS NP_010276 165 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit 11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010276 VERSION NP_010276.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180067.3 REFERENCE 1 (residues 1 to 165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 165) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11839. On Jul 30, 2012 this sequence version replaced NP_010276.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..165 /product="anaphase promoting complex subunit 11" /calculated_mol_wt="18734" Region 1..102 /region_name="zf-ANAPC11" /note="Anaphase-promoting complex subunit 11 RING-H2 finger; pfam12861" /db_xref="CDD:403920" Site order(43..45,49,53..54,56,60,66,80) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:438120" CDS 1..165 /gene="APC11" /locus_tag="YDL008W" /coded_by="NM_001180067.3:1..498" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:10888670]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473]" /note="Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity" /db_xref="GeneID:851554" /db_xref="SGD:S000002166" ORIGIN 1 mkvkinevhs vfawswhips tsdedaannd pigndededv cgicrasyng tcpsckfpgd 61 qcplviglch hnfhdhciyr wldtptskgl cpmcrqtfql qkglaindah vqkfveivsr 121 rreemieegv aeefvdfdep irqntdnpig rqqvdtilde dfllr // LOCUS NP_001032574 85 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDL007C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032574 VERSION NP_001032574.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184682.1 REFERENCE 1 (residues 1 to 85) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 85) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 85) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 85) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11840. Method: conceptual translation. FEATURES Location/Qualifiers source 1..85 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..85 /product="uncharacterized protein" /calculated_mol_wt="9502" CDS 1..85 /locus_tag="YDL007C-A" /coded_by="NM_001184682.1:1..258" /note="hypothetical protein" /db_xref="GeneID:3799969" /db_xref="SGD:S000113557" ORIGIN 1 mflpiifhti ltllnfgkyy clpiqedddk sgkeieqild nnieslglll nsmslssnft 61 tgdpeldslf qddlipelys vldgf // LOCUS NP_010277 437 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle base subunit RPT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010277 VERSION NP_010277.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180066.1 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11841. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..437 /product="proteasome regulatory particle base subunit RPT2" /calculated_mol_wt="48697" Region 1..437 /region_name="PTZ00361" /note="26 proteosome regulatory subunit 4-like protein; Provisional" /db_xref="CDD:185575" CDS 1..437 /gene="RPT2" /locus_tag="YDL007W" /gene_synonym="YHS4; YTA5" /coded_by="NM_001180066.1:1..1314" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15210724]" /experiment="EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:7721833]" /experiment="EXISTENCE:direct assay:GO:0045732 positive regulation of protein catabolic process [PMID:15135049]" /experiment="EXISTENCE:genetic interaction:GO:0036402 proteasome-activating activity [PMID:11430818]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9724628]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:23102099]" /experiment="EXISTENCE:mutant phenotype:GO:0036402 proteasome-activating activity [PMID:11430818]" /experiment="EXISTENCE:mutant phenotype:GO:0043171 peptide catabolic process [PMID:9724628]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:22505030]" /experiment="EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19412160]" /note="ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle; N-myristoylation of Rpt2p at Gly2 is involved in regulating the proper intracellular distribution of proteasome activity by controlling the nuclear localization of the 26S proteasome" /db_xref="GeneID:851557" /db_xref="SGD:S000002165" ORIGIN 1 mgqgvssgqd kkkkkgsnqk pkyeppvqsk fgrkkrkggp ataeklpniy pstrcklkll 61 rmerikdhll leeefvsnse ilkpfekkqe eekkqleeir gnplsigtle eiidddhaiv 121 tsptmpdyyv silsfvdkel lepgcsvllh hktmsivgvl qddadpmvsv mkmdksptes 181 ysdigglesq iqeikesvel plthpelyee mgikppkgvi lygapgtgkt llakavanqt 241 satflrivgs eliqkylgdg prlcrqifkv agenapsivf ideidaigtk rydsnsgger 301 eiqrtmlell nqldgfddrg dvkvimatnk ietldpalir pgridrkilf enpdlstkkk 361 ilgihtskmn lsedvnletl vttkddlsga diqamcteag llalrerrmq vtaedfkqak 421 ervmknkvee nleglyl // LOCUS NP_010278 281 aa linear PLN 30-JUN-2025 DEFINITION type 2C protein phosphatase PTC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010278 VERSION NP_010278.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180065.3 REFERENCE 1 (residues 1 to 281) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 281) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 281) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 281) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11842. On Jul 30, 2012 this sequence version replaced NP_010278.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..281 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..281 /product="type 2C protein phosphatase PTC1" /EC_number="3.1.3.16" /calculated_mol_wt="31419" Region 12..279 /region_name="PP2Cc" /note="Serine/threonine phosphatases, family 2C, catalytic domain; smart00332" /db_xref="CDD:214625" Site order(32,36..37,58..60,233,272) /site_type="active" /db_xref="CDD:238083" CDS 1..281 /gene="PTC1" /locus_tag="YDL006W" /gene_synonym="CWH47; KCS2; TPD1" /coded_by="NM_001180065.3:1..846" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:26546002|PMID:10580002]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11113180]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11113180]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:1990439 MAP kinase serine/threonine phosphatase activity [PMID:11113180]" /experiment="EXISTENCE:genetic interaction:GO:0043409 negative regulation of MAPK cascade [PMID:26546002]" /experiment="EXISTENCE:genetic interaction:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:26546002]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:9529388]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:20400943]" /experiment="EXISTENCE:mutant phenotype:GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation [PMID:8196609]" /experiment="EXISTENCE:mutant phenotype:GO:0043409 negative regulation of MAPK cascade [PMID:26546002]" /experiment="EXISTENCE:mutant phenotype:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:26546002]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:14685261]" /note="Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating the osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation; involved in myosin-V dependent inheritance of mitochondria, peroxisomes, vacuoles and secretory vesicles; localizes to the nucleus, cytoplasm and peroxisomes" /db_xref="GeneID:851558" /db_xref="SGD:S000002164" ORIGIN 1 msnhseiler petpydityr vgvaenknsk frrtmedvht yvknfasrld wgyfavfdgh 61 agiqaskwcg khlhtiieqn iladetrdvr dvlndsflai deeintklvg nsgctaavcv 121 lrwelpdsvs ddsmdlaqhq rklytanvgd srivlfrngn sirltydhka sdtlemqrve 181 qagglimksr vngmlavtrs lgdkffdslv vgspfttsve itsedkflil acdglwdvid 241 dqdacelikd itepneaakv lvryalengt tdnvtvmvvf l // LOCUS NP_010279 431 aa linear PLN 30-JUN-2025 DEFINITION Med2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010279 VERSION NP_010279.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180064.3 REFERENCE 1 (residues 1 to 431) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 431) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 431) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 431) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11843. On Jul 30, 2012 this sequence version replaced NP_010279.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..431 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..431 /product="Med2p" /calculated_mol_wt="47587" Region 27..141 /region_name="Med2" /note="Mediator complex subunit 2; pfam11214" /db_xref="CDD:402683" CDS 1..431 /gene="MED2" /locus_tag="YDL005C" /coded_by="NM_001180064.3:1..1296" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:9891034]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12468546]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12482986]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15254252]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:33045248]" /experiment="EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11470794]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11470794]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:851559" /db_xref="SGD:S000002163" ORIGIN 1 mvvqnspvss vhtanfserg sntrtmtykn kltvcfddil kvgaemmmqq qlknvqldsy 61 lvngfsqsqq kllkekvklf hgilddlets lsqsssylet ltalgkekek ereeaekkra 121 eqenmrkvre qeelkkrqel eeasqqqqlq qnskeknglg lnfsttapan ttdangsken 181 yqelgslqss sqtqlenana anngaafspl tttriqsqqa qpsdvmfndl nsmdismfsg 241 ldstgfdsta fnatvdetkg fddndsgnny ndinissien ninnninstk ngkdnnnesn 301 knnngdeknk nnnednennn nsseknnnnn nnnnnnnddn gnnnnnnsgn dnnnttnnds 361 nnknnsittg ndnenivnnd lpttvvsnpg dnpppadnge eyltlndfnd lnidwsttgd 421 ngeldlsgfn i // LOCUS NP_010280 160 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit delta [Saccharomyces cerevisiae S288C]. ACCESSION NP_010280 VERSION NP_010280.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180063.1 REFERENCE 1 (residues 1 to 160) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 160) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 160) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11844. Method: conceptual translation. FEATURES Location/Qualifiers source 1..160 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..160 /product="F1F0 ATP synthase subunit delta" /calculated_mol_wt="16889" Region 32..154 /region_name="F1-ATPase_delta" /note="mitochondrial ATP synthase delta subunit; cd12152" /db_xref="CDD:213395" Site order(35,38..40,42,45,68..72,94..99,106,108..110) /site_type="other" /note="gamma subunit interface [polypeptide binding]" /db_xref="CDD:213395" Site order(40,57,73..74,76,91,93..95,110..111,113,116..117,119, 126,143..144,146..147,150,152) /site_type="other" /note="epsilon subunit interface [polypeptide binding]" /db_xref="CDD:213395" Site order(51,53,59..60,62,64,66..68) /site_type="other" /note="LBP interface [polypeptide binding]" /db_xref="CDD:213395" CDS 1..160 /gene="ATP16" /locus_tag="YDL004W" /coded_by="NM_001180063.1:1..483" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0045259 proton-transporting ATP synthase complex [PMID:17082766]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:8026496]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:8026496]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:8026496]" /note="Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated" /db_xref="GeneID:851560" /db_xref="SGD:S000002162" ORIGIN 1 mlrsiigksa srslnfvakr syaeaaaass glklqfalph etlysgsevt qvnlpaksgr 61 igvlanhvpt veqllpgvve vmegsnskkf fisggfatvq pdsqlcvtai eafplesfsq 121 eniknllaea kknvsssdar eaaeaaiqve vlenlqsvlk // LOCUS NP_010281 566 aa linear PLN 30-JUN-2025 DEFINITION kleisin alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_010281 VERSION NP_010281.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180062.1 REFERENCE 1 (residues 1 to 566) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 566) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 566) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 566) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11845. Method: conceptual translation. FEATURES Location/Qualifiers source 1..566 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..566 /product="kleisin alpha" /calculated_mol_wt="63159" Region 17..108 /region_name="Rad21_Rec8_N" /note="N terminus of Rad21 / Rec8 like protein; pfam04825" /db_xref="CDD:461446" Region 315..394 /region_name="Rad21_Rec8_M_ScScc1p-like" /note="Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and similar proteins; cd21791" /db_xref="CDD:439293" Site order(318..320,323..330,333,336..337,342..349,359,361..362, 365..370,375..376,378..385) /site_type="other" /note="putative HEAT-repeat binding site [polypeptide binding]" /db_xref="CDD:439293" Region 505..559 /region_name="Rad21_Rec8" /note="Conserved region of Rad21 / Rec8 like protein; pfam04824" /db_xref="CDD:335912" CDS 1..566 /gene="MCD1" /locus_tag="YDL003W" /gene_synonym="PDS3; RHC21; SCC1" /coded_by="NM_001180062.1:1..1701" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:18614046]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:9990856|PMID:18614046]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:18321989]" /experiment="EXISTENCE:direct assay:GO:0030892 mitotic cohesin complex [PMID:9990856]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:27325700]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:11448778|PMID:23178808]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:18321989]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:18614046]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:9335334]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:16962805]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:16888651]" /experiment="EXISTENCE:physical interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:27325700]" /experiment="EXISTENCE:physical interaction:GO:0019901 protein kinase binding [PMID:27325700]" /note="Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis; subject to proteolytic cleavage by separase Esp1p, resulting in dissociation of cohesin from chromatin and the separation of sister chromatids at the mitotic metaphase-to-anaphase transition; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase" /db_xref="GeneID:851561" /db_xref="SGD:S000002161" ORIGIN 1 mvtenpqrlt vlrlatnkgp laqiwlasnm sniprgsviq thiaesakei akasgcddes 61 gdneyitlrt sgellqgivr vyskqatfll tdikdtltki smlfktsqkm tstvnrlntv 121 trvhqlmled avterevlvt pgleflddtt ipvglmaqen smerkvqgaa pwdtslevgr 181 rfspdedfeh nnlssmnldf dieegpitsk sweegtrqss rnfdthenyi qdddfpldda 241 gtigwdlgit ekndqnnddd dnsveqgrrl gesimseept dfgfdldiek eapagnidti 301 tdamtesqpk qtgtrrnskl lntksiqide etensesias sntykeersn nlltpqptnf 361 ttkrlwseit esmsylpdpi lknflsyesl kkrkihngre gsieepelnv slnltddvis 421 nagtndnsfn eltdnmsdfv pidaglneap fpeeniidak trneqttiqt ekvrptpgev 481 askaivqmak ilrkelseek eviftdvlks qantepenit kreasrgffd ilslategci 541 glsqteafgn ikidakpalf erfina // LOCUS NP_010282 203 aa linear PLN 30-JUN-2025 DEFINITION Nhp10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010282 VERSION NP_010282.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180061.3 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11846. On Jul 30, 2012 this sequence version replaced NP_010282.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..203 /product="Nhp10p" /calculated_mol_wt="23726" Region 24..203 /region_name="NHP6B" /note="Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]; COG5648" /db_xref="CDD:227935" CDS 1..203 /gene="NHP10" /locus_tag="YDL002C" /gene_synonym="HMO2" /coded_by="NM_001180061.3:1..612" /experiment="EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:19726587]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12887900]" /experiment="EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:12887900]" /experiment="EXISTENCE:direct assay:GO:0045027 DNA end binding [PMID:19726587]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:15607974]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:17762868]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Non-essential INO80 chromatin remodeling complex subunit; preferentially binds DNA ends, protecting them from exonucleatic cleavage; deletion affects telomere maintenance via recombination; related to mammalian high mobility group proteins" /db_xref="GeneID:851562" /db_xref="SGD:S000002160" ORIGIN 1 msveekkrrl eelkdqnvvl glaiqrsrls vkrlkleygv llerlesrie ldpelncedp 61 lptlasfkqe lltkpfrksk tkrhkvkerd pnmpkrptna yllycemnke rirqngsldv 121 trdlaegwkn lneqdrkpyy klysedrery qmemeiynkk isnidadddk eeneqkiknn 181 eegsstkvad skggedgslv ssn // LOCUS NP_010283 430 aa linear PLN 30-JUN-2025 DEFINITION Rmd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010283 VERSION NP_010283.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180060.3 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11847. On Jul 30, 2012 this sequence version replaced NP_010283.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..430 /product="Rmd1p" /calculated_mol_wt="49801" Region 205..377 /region_name="DUF155" /note="RMND1/Sif2-Sif3/Mrx10, DUF155; pfam02582" /db_xref="CDD:460604" CDS 1..430 /gene="RMD1" /locus_tag="YDL001W" /coded_by="NM_001180060.3:1..1293" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic protein required for sporulation; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:851563" /db_xref="SGD:S000002159" ORIGIN 1 mvdsnddqpe rhallhndiq tsnnsrpslv qkkylptpqd trksrasytg saminptskq 61 srtgsgaqrt srtaqklkll peepfqrdse rltdlknqev ysqvnrikdk parrdaeklg 121 kahrhllprs tayctassyn mkelvrwlkd crklhhthpk lfdeclytpf iyndwrgdkr 181 fededvirld deggeiivsd khpdlfifey gvvvmwgfte reekaflndi ekfekeklae 241 ediqveefny yvtksyqpri yndfitlrdg snymvklsis haiaqsvkis lfeelvdnti 301 edtqdipqei aysgkvsmsk edimksigel filrininlh gsvldspeim wsepqlepiy 361 qatrgylein qrvsllnqrl evisdllqml keqlghshee ylefivillv gvevlisvin 421 ivvdmlasqh // LOCUS NP_010284 751 aa linear PLN 30-JUN-2025 DEFINITION alpha,alpha-trehalase NTH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010284 VERSION NP_010284.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180309.1 REFERENCE 1 (residues 1 to 751) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 751) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 751) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 751) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11848. Method: conceptual translation. FEATURES Location/Qualifiers source 1..751 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..751 /product="alpha,alpha-trehalase NTH1" /EC_number="3.2.1.28" /calculated_mol_wt="85748" Region 106..135 /region_name="Trehalase_Ca-bi" /note="Neutral trehalase Ca2+ binding domain; pfam07492" /db_xref="CDD:429490" Region 163..721 /region_name="Trehalase" /note="pfam01204" /db_xref="CDD:395961" CDS 1..751 /gene="NTH1" /locus_tag="YDR001C" /coded_by="NM_001180309.1:1..2256" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0005993 trehalose catabolic process [PMID:23597844]" /experiment="EXISTENCE:mutant phenotype:GO:0071465 cellular response to desiccation [PMID:25456447]" /note="Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to coordinately regulate carbohydrate metabolism and the cell cycle; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication" /db_xref="GeneID:851564" /db_xref="SGD:S000002408" ORIGIN 1 msqvntsqgp vaqgrqrrls slsefndpfs naevyygppt dprkqkqakp akinrtrtms 61 vfdnvspfkk tgfgklqqtr rgseddtyss sqgnrrffie dvdktlnell aaedtdknyq 121 itiedtgpkv lkvgtansyg ykhinirgty mlsnllqelt iaksfgrhqi fldearinen 181 pvnrlsrlin tqfwnsltrr vdlnnvgeia kdtkidtpga knpriyvpyd cpeqyefyvq 241 asqmhpslkl eveylpkkit aeyvksvndt pgllalamee hfnpstgekt ligypyavpg 301 grfnelygwd symmalglle anktdvargm vehfifeinh ygkilnanrs yylcrsqppf 361 ltemalvvfk klggrsnpda vdllkrafqa sikeyktvwt asprldpetg lsryhpnglg 421 ippetesdhf dtvllpyask hgvtldefkq lyndgkikep kldefflhdr gvresghdtt 481 yrfegvcayl atidlnslly kyeidiadfi kefcddkyed pldhsittsa mwkemakirq 541 ekitkymwdd esgfffdynt kikhrtsyes attfwalwag latkeqaqkm vekalpklem 601 lgglaacter srgpisisrp irqwdypfgw aphqilaweg lrsygyltvt nrlayrwlfm 661 mtkafvdyng ivvekydvtr gtdphrveae ygnqgadfkg aategfgwvn asyilglkym 721 nsharralga cippisffss lrpqernlyg l // LOCUS NP_010285 201 aa linear PLN 30-JUN-2025 DEFINITION Ran GTPase-binding protein YRB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010285 VERSION NP_010285.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180310.1 REFERENCE 1 (residues 1 to 201) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 201) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 201) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 201) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11849. Method: conceptual translation. FEATURES Location/Qualifiers source 1..201 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..201 /product="Ran GTPase-binding protein YRB1" /calculated_mol_wt="22822" Region 1..201 /region_name="YRB1" /note="Ran GTPase-activating protein (Ran-binding protein) [Intracellular trafficking and secretion]; COG5171" /db_xref="CDD:227499" CDS 1..201 /gene="YRB1" /locus_tag="YDR002W" /gene_synonym="CST20; HTN1; SFO1; STP52" /coded_by="NM_001180310.1:1..606" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10825193]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10825193]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:7836422]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10991951]" /experiment="EXISTENCE:mutant phenotype:GO:0006405 RNA export from nucleus [PMID:7489726]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10991951]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:7489726]" /note="Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1" /db_xref="GeneID:851565" /db_xref="SGD:S000002409" ORIGIN 1 mssedkkpvv dkkeeaapkp pssavfsmfg gkkaekpetk kdeedtkeet kkegddapes 61 pdihfepvvh lekvdvktme edeevlykvr aklfrfdada kewkergtgd ckflknkktn 121 kvrilmrrdk tlkicanhii apeytlkpnv gsdrswvyac tadiaegeae aftfairfgs 181 kenadkfkee fekaqeinkk a // LOCUS NP_010286 210 aa linear PLN 30-JUN-2025 DEFINITION Rcr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010286 VERSION NP_010286.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180311.3 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11850. On Jul 30, 2012 this sequence version replaced NP_010286.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..210 /product="Rcr2p" /calculated_mol_wt="24080" Region 40..152 /region_name="RCR" /note="Chitin synthesis regulation, resistance to Congo red; pfam12273" /db_xref="CDD:432443" CDS 1..210 /gene="RCR2" /locus_tag="YDR003W" /gene_synonym="SSH5" /coded_by="NM_001180311.3:1..633" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:32421152|PMID:14562095|PMID:17287526]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:32421152]" /experiment="EXISTENCE:direct assay:GO:0031982 vesicle [PMID:17287526]" /experiment="EXISTENCE:direct assay:GO:0072665 protein localization to vacuole [PMID:32421152]" /experiment="EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17287526]" /note="Vacuolar ubiquitin ligase-substrate adaptor; delivered to vacuole using ubiquitin as a sorting signal; presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; RCR2 has a paralog, RCR1, that arose from the whole genome duplication" /db_xref="GeneID:851566" /db_xref="SGD:S000002410" ORIGIN 1 milreqidfl ihkrqddnnn ngeaitdddp fsssswrwgr wiffiffiva llillfstak 61 vnrrrrimgq apirgtawlt pptyrqserd yngtqrcved yvpeytetan endlgfyder 121 gefhpngkte ylappplsee qasstdkdlq rpvaavvrip sesefdfnll rptmnnfvng 181 qsnrneqhsp tvesssfdvn naparakvsk // LOCUS NP_878061 40 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR003W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878061 VERSION NP_878061.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184646.3 REFERENCE 1 (residues 1 to 40) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 40) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 40) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 40) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11851. On Jul 30, 2012 this sequence version replaced NP_878061.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..40 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..40 /product="uncharacterized protein" /calculated_mol_wt="4711" CDS 1..40 /locus_tag="YDR003W-A" /coded_by="NM_001184646.3:1..123" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466432" /db_xref="SGD:S000028819" ORIGIN 1 mtcgiensyk saekkkkyrs frffesrdys elciivgtyy // LOCUS NP_010287 460 aa linear PLN 30-JUN-2025 DEFINITION putative DNA-dependent ATPase RAD57 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010287 VERSION NP_010287.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180312.1 REFERENCE 1 (residues 1 to 460) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 460) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 460) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 460) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11852. Method: conceptual translation. FEATURES Location/Qualifiers source 1..460 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..460 /product="putative DNA-dependent ATPase RAD57" /calculated_mol_wt="52117" Region 107..445 /region_name="XRCC3" /note="XRCC3 recombinase; cd19491" /db_xref="CDD:410899" Site order(128..133,161,225,273,404) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:410899" CDS 1..460 /gene="RAD57" /locus_tag="YDR004W" /coded_by="NM_001180312.1:1..1383" /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:9159392]" /experiment="EXISTENCE:direct assay:GO:0033065 Rad51C-XRCC3 complex [PMID:9159392]" /experiment="EXISTENCE:mutant phenotype:GO:0000707 meiotic DNA recombinase assembly [PMID:9679065]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:11238918]" /experiment="EXISTENCE:physical interaction:GO:0000730 DNA recombinase assembly [PMID:11459983]" /note="Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p" /db_xref="GeneID:851567" /db_xref="SGD:S000002411" ORIGIN 1 mpralsikfd ntymdlydel peskllydee fsylldavrq ngvcvvdflt ltpkelarli 61 qrsinevfrf qqllvheyne kyleicekns ispdngpecf ttadvamdel lgggifthgi 121 teifgesstg ksqllmqlal svqlsepagg lggkcvyitt egdlptqrle smlssrpaye 181 klgitqsnif tvscndlinq ehiinvqlpi llerskgsik lviidsishh lrvelqnksf 241 resqenknyl drmaeklqil ahdyslsvvv anqvgdkpla nspvahrtyv tdydyqlgwl 301 vgwknstily rqmnsllgas snndeilsdd edymliervm stvndrnydf fskkkppiie 361 nktvernsss pisrqskkrk fdyrvpnlgl twsnhvstri llqksfkast iiqrgeahly 421 kggdsasfwq vkrtmkvvys tfakpgqiay qitkrgieta // LOCUS NP_010288 395 aa linear PLN 30-JUN-2025 DEFINITION RNA polymerase III-inhibiting protein MAF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010288 VERSION NP_010288.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180313.1 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11853. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..395 /product="RNA polymerase III-inhibiting protein MAF1" /calculated_mol_wt="44602" Region 81..387 /region_name="Maf1" /note="Maf1 regulator; cl02103" /db_xref="CDD:470466" CDS 1..395 /gene="MAF1" /locus_tag="YDR005C" /coded_by="NM_001180313.1:1..1188" /experiment="EXISTENCE:direct assay:GO:0000994 RNA polymerase III core binding [PMID:20887893|PMID:16762835]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19574957|PMID:19684113|PMID:16762835]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19574957]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16762835|PMID:19574957|PMID:19684113]" /experiment="EXISTENCE:direct assay:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:16762835]" /experiment="EXISTENCE:genetic interaction:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:11438659]" /experiment="EXISTENCE:mutant phenotype:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:16762835|PMID:11438659]" /experiment="EXISTENCE:physical interaction:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:11438659|PMID:16762835]" /note="Highly conserved negative regulator of RNA polymerase III; involved in tRNA processing and stability; inhibits tRNA degradation via rapid tRNA decay (RTD) pathway; binds N-terminal domain of Rpc160p subunit of Pol III to prevent closed-complex formation; regulated by phosphorylation mediated by TORC1, protein kinase A, Sch9p, casein kinase 2; localizes to cytoplasm during vegetative growth and translocates to nucleus and nucleolus under stress conditions" /db_xref="GeneID:851568" /db_xref="SGD:S000002412" ORIGIN 1 mkfideldie rvnqtlnfet ndckivgscd ifttkavasd rklyktidqh ldtilqenen 61 ynatlqqqla apetnqspcs spfysnrrds nsfweqkrri sfseynsnnn tnnsngnssn 121 nnnysgpngs spatfpksak lndqnlkelv snydsgsmss ssldsssknd erirrrssss 181 issfksgkss nnnyssgtat nnvnkrrkss inerpsnlsl gpfgpineps srkifaylia 241 ilnasypdhd fssveptdfv ktslktfisk fentlyslgr qpeewvwevi nshmtlsdcv 301 lfqyspsnsf ledepgylwn ligflynrkr krvaylylic srlnsstgev edalakkpqg 361 kliiddgsne yegeydftyd enviddksdq eeslq // LOCUS NP_010289 901 aa linear PLN 30-JUN-2025 DEFINITION Sok1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010289 VERSION NP_010289.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180314.3 REFERENCE 1 (residues 1 to 901) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 901) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 901) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 901) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11854. On Jul 30, 2012 this sequence version replaced NP_010289.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..901 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..901 /product="Sok1p" /calculated_mol_wt="100951" Region 390..791 /region_name="Tcp11" /note="T-complex protein 11; pfam05794" /db_xref="CDD:461743" CDS 1..901 /gene="SOK1" /locus_tag="YDR006C" /coded_by="NM_001180314.3:1..2706" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8065298]" /experiment="EXISTENCE:genetic interaction:GO:0141156 cAMP/PKA signal transduction [PMID:8065298]" /note="hypothetical protein; overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13" /db_xref="GeneID:851569" /db_xref="SGD:S000002413" ORIGIN 1 mdqprthsgp ttasnpapss tnsssapsat nskqerssss lskpssvvps kdspdgdaia 61 ktqaaalknd mksgdtstld gssqniipnr asmqkyidqs sdllsrssgv itpsmslnas 121 tnatnndssg nsanssdlki pidrdntifk tfdtktgqfl knddneeeir rnnkvdsipp 181 kniytninnp spspppsskq ppsasapqlp patephkeqa aqqqppgnas nflrifsnkk 241 mrshsvptil hsslrklssh nqyyrnqnil lnhptpsgis kkkfsrnhhq pylhsnnpls 301 snplslkrai flnqqisgna stnanndnin nstatsmtnq sflsssnfdl tledrinyik 361 atptpvpfpp inlqglkeid lqeilknpql rhdiifdpll qfrpnldger gnkkrqlani 421 ywndvqneiy vyskrpeifq ynrsrlvplf dtlrdvllti vpqkespmin nvldtelniq 481 ellkgslims nlsgwladlf khhcapmrdp wvdkmsnkfk eaerdssltr lieglrlvfq 541 iletmkldia nhqirilrpa llsnavefek qyfntliask rvnlntsllw fdkkfnenvt 601 aglvrnpssi tipdvynici rsiinllscr kmvreyptpl sfdharlill radirqivci 661 lvcrllfqql vandpsmdka tkeyvihtys tkrlkneiis iitdehgncr wtkntmsiav 721 hlckviddlh reydnngsce qarrpqlpsl dnskitfaks wlskqtqpls evygvlenrv 781 fksledaifn rsectidgrv kqdfvylynt nngnvgstnt lstttdtasv kispslmsps 841 ktstttptgn aiasrglfaa teleefenvy rhlyalinlh wsvfgphyie mlgdkvnkkg 901 i // LOCUS NP_010290 224 aa linear PLN 30-JUN-2025 DEFINITION phosphoribosylanthranilate isomerase TRP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010290 VERSION NP_010290.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180315.3 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11855. On Jul 30, 2012 this sequence version replaced NP_010290.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..224 /product="phosphoribosylanthranilate isomerase TRP1" /EC_number="5.3.1.24" /calculated_mol_wt="24013" Site order(15,17,39,98,100,145,199,201..202) /site_type="active" /db_xref="CDD:238237" Region 24..220 /region_name="PRAI" /note="N-(5'phosphoribosyl)anthranilate (PRA) isomerase; pfam00697" /db_xref="CDD:395566" CDS 1..224 /gene="TRP1" /locus_tag="YDR007W" /coded_by="NM_001180315.3:1..675" /experiment="EXISTENCE:direct assay:GO:0000162 L-tryptophan biosynthetic process [PMID:3286643]" /experiment="EXISTENCE:direct assay:GO:0004640 phosphoribosylanthranilate isomerase activity [PMID:3286643]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000162 L-tryptophan biosynthetic process [PMID:10790693|PMID:348687]" /experiment="EXISTENCE:mutant phenotype:GO:0004640 phosphoribosylanthranilate isomerase activity [PMID:348687]" /note="Phosphoribosylanthranilate isomerase; catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA); enhances vegetative growth at low and high temperatures when used as an auxotrophic marker in strains such as W303" /db_xref="GeneID:851570" /db_xref="SGD:S000002414" ORIGIN 1 msvinftgss gplvkvcglq steaaecald sdadllgiic vpnrkrtidp viarkisslv 61 kayknssgtp kylvgvfrnq pkedvlalvn dygidivqlh gdeswqeyqe flglpvikrl 121 vfpkdcnill saasqkphsf iplfdseagg tgelldwnsi sdwvgrqesp eslhfmlagg 181 ltpenvgdal rlngvigvdv sggvetngvk dsnkianfvk nakk // LOCUS NP_010292 520 aa linear PLN 30-JUN-2025 DEFINITION transcriptional regulator GAL3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010292 VERSION NP_010292.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180317.1 REFERENCE 1 (residues 1 to 520) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 520) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 520) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 520) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11856. Method: conceptual translation. FEATURES Location/Qualifiers source 1..520 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..520 /product="transcriptional regulator GAL3" /calculated_mol_wt="57998" Region 23..516 /region_name="gal_kin" /note="galactokinase; TIGR00131" /db_xref="CDD:272924" CDS 1..520 /gene="GAL3" /locus_tag="YDR009W" /coded_by="NM_001180317.1:1..1563" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18952899]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10866670|PMID:18952899]" /experiment="EXISTENCE:mutant phenotype:GO:0006012 galactose metabolic process [PMID:4577139]" /experiment="EXISTENCE:mutant phenotype:GO:0045185 maintenance of protein location [PMID:19651897]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3013721]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:8628318]" /note="Transcriptional regulator; involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity; GAL3 has a paralog, GAL1, that arose from the whole genome duplication" /db_xref="GeneID:851572" /db_xref="SGD:S000002416" ORIGIN 1 mntnvpifss pvrdlprsfe qkhlavvdaf fqtyhvkpdf iarspgrvnl igehidycdf 61 svlplaidvd mlcavkilde knpsitltna dpkfaqrkfd lpldgsymai dpsvsewsny 121 fkcglhvahs ylkkiaperf nntplvgaqi fcqsdiptgg glssaftcaa alatiranmg 181 knfdiskkdl tritavaehy vgvnnggmdq atsvygeedh alyvefrpkl katpfkfpql 241 knheisfvia ntlvksnkfe taptnynlrv ievtvaanal atrysvalps hkdnsnserg 301 nlrdfmdayy aryenqaqpw ngdigtgier llkmlqlvee sfsrkksgft vheastalnc 361 sreeftrdyl ttfpvrfqvl klyqrakhvy seslrvlkal kmmtsatfht dedfftdfgr 421 lmnesqascd klyecsciet nqicsialan gsfgsrltga gwggctihlv psgangnveq 481 vrkaliekfy nvrypdltde elkdaiivsk palgtclyeq // LOCUS NP_001335754 110 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR010C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335754 VERSION NP_001335754.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348808.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80274. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..110 /product="uncharacterized protein" /calculated_mol_wt="12563" CDS 1..110 /locus_tag="YDR010C" /coded_by="NM_001348808.1:1..333" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:851573" /db_xref="SGD:S000002417" ORIGIN 1 mcaepddwer ierhprklki aprmldfyes yivwregnff lclrsfpngv irggrcffra 61 tslpwknvyg yhghitsvcg atltrinram vasdagmgsi gltnlflyrv // LOCUS NP_010294 1501 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette transporter SNQ2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010294 VERSION NP_010294.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180319.1 REFERENCE 1 (residues 1 to 1501) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1501) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1501) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1501) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11857. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1501 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1501 /product="ATP-binding cassette transporter SNQ2" /calculated_mol_wt="168636" Region 103..1480 /region_name="3a01205" /note="Pleiotropic Drug Resistance (PDR) Family protein; TIGR00956" /db_xref="CDD:273362" CDS 1..1501 /gene="SNQ2" /locus_tag="YDR011W" /coded_by="NM_001180319.1:1..4506" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030003 intracellular monoatomic cation homeostasis [PMID:8985171]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:8985171]" /note="Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species" /db_xref="GeneID:851574" /db_xref="SGD:S000002418" ORIGIN 1 msnikstqds shnavarsss asfaaseesf tgithdkdeq sdtpadkltk mltgpardta 61 sqisatvsem apdvvskves fadalsrhtt rsgafnmdsd sddgfdahai fesfvrdade 121 qgihirkagv tiedvsakgv dasalegatf gnilclplti fkgikakrhq kmrqiisnvn 181 alaeagemil vlgrpgagcs sflkvtagei dqfaggvsge vaydgipqee mmkrykadvi 241 yngeldvhfp yltvkqtldf aiacktpalr vnnvskkeyi asrrdlyati fglrhtyntk 301 vgndfvrgvs ggerkrvsia ealaakgsiy cwdnatrgld astaleyaka irimtnllks 361 tafvtiyqas eniyetfdkv tvlysgkqiy fgliheakpy fakmgylcpp rqataeflta 421 ltdpngfhli kpgyenkvpr taeefetywl nspefaqmkk diaaykekvn tektkevyde 481 smaqekskyt rkksyytvsy weqvklctqr gfqriygnks ytvinvcsai iqsfitgslf 541 yntpsstsga fsrggvlyfa llyyslmgla nisfehrpil qkhkgyslyh psaeaigstl 601 asfpfrmigl tcffiilffl sglhrtagsf ftiylfltmc seainglfem vssvcdtlsq 661 ansisgilmm sismystymi qlpsmhpwfk wisyvlpiry afesmlnaef hgrhmdcant 721 lvpsggdydn lsddykvcaf vgskpgqsyv lgddylknqf qyvykhtwrn fgilwcfllg 781 yvvlkvifte ykrpvkgggd alifkkgskr fiahadeesp dnvndidake qfssessgan 841 devfddleak gvfiwkdvcf tipyeggkrm lldnvsgyci pgtmtalmge sgagkttlln 901 tlaqrnvgii tgdmlvngrp idasferrtg yvqqqdihia eltvreslqf sarmrrpqhl 961 pdsekmdyve kiirvlgmee yaealvgevg cglnveqrkk lsigvelvak pdlllfldep 1021 tsgldsqssw aiiqllrkls kagqsilcti hqpsatlfee fdrllllrkg gqtvyfgdig 1081 knsatilnyf erngarkcds senpaeyile aigagatasv kedwhekwln svefeqtkek 1141 vqdlindlsk qetksevgdk pskyatsyay qfryvlirts tsfwrslnyi mskmmlmlvg 1201 glyigftffn vgksyvglqn amfaafisii lsapamnqiq graiasrelf evresqsnmf 1261 hwslvlitqy lselpyhlff stiffvssyf plriffeasr savyflnyci mfqlyyvglg 1321 lmilymspnl psanvilglc lsfmlsfcgv tqpvslmpgf wtfmwkaspy tyfvqnlvgi 1381 mlhkkpvvck kkelnyfnpp ngstcgeymk pflekatgyi enpdatsdca yciyevgdny 1441 lthisskysy lwrnfgifwi yiffniiamv cvyylfhvrq ssflspvsil nkiknirkkk 1501 q // LOCUS NP_010295 362 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL4 RPL4B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010295 VERSION NP_010295.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180320.3 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11858. On Jul 30, 2012 this sequence version replaced NP_010295.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..362 /product="60S ribosomal protein uL4 RPL4B" /calculated_mol_wt="38931" Region 2..350 /region_name="PTZ00428" /note="60S ribosomal protein L4; Provisional" /db_xref="CDD:185611" CDS 1..362 /gene="RPL4B" /locus_tag="YDR012W" /coded_by="NM_001180320.3:1..1089" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:22096102]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]" /note="Ribosomal 60S subunit protein L4B; homologous to mammalian ribosomal protein L4 and bacterial L4; RPL4B has a paralog, RPL4A, that arose from the whole genome duplication" /db_xref="GeneID:851575" /db_xref="SGD:S000002419" ORIGIN 1 msrpqvtvhs ltgeatanal plpavfsapi rpdivhtvft svnknkrqay avsekaghqt 61 saeswgtgra variprvggg gtgrsgqgaf gnmcrggrmf aptktwrkwn vkvnhnekry 121 atasaiaata vaslvlargh rvekipeipl vvstdlesiq ktkeavaalk avgahsdllk 181 vlkskklrag kgkyrnrrwt qrrgplvvya edngivkalr nvpgvetanv aslnllqlap 241 gahlgrfviw teaaftkldq vwgsetvass kvgytlpshi istsdvtrii nsseiqsair 301 pagqatqkrt hvlkknplkn kqvllrlnpy akvfaaeklg skkaektgtk paavfaetlk 361 hd // LOCUS NP_010296 208 aa linear PLN 30-JUN-2025 DEFINITION DNA replication protein PSF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010296 VERSION NP_010296.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180321.3 REFERENCE 1 (residues 1 to 208) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 208) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 208) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 208) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11859. On Jul 30, 2012 this sequence version replaced NP_010296.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..208 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..208 /product="DNA replication protein PSF1" /calculated_mol_wt="24073" Region 1..208 /region_name="COG5230" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227555" CDS 1..208 /gene="PSF1" /locus_tag="YDR013W" /gene_synonym="CDC101" /coded_by="NM_001180321.3:1..627" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:genetic interaction:GO:0031261 DNA replication preinitiation complex [PMID:12730134]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:12730134|PMID:12768207]" /experiment="EXISTENCE:mutant phenotype:GO:0031261 DNA replication preinitiation complex [PMID:12730134]" /experiment="EXISTENCE:physical interaction:GO:0000811 GINS complex [PMID:12730134|PMID:12768207]" /note="Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" /db_xref="GeneID:851576" /db_xref="SGD:S000002420" ORIGIN 1 mygdlgnklv leakrtkqly arsnqdvnlp myhediirni lkevsnlrkn teylkeqqql 61 gmlddkvakc qyfvtllcme rnkrcllayq rlrtdildsm awnnngldlm ssitfsqqdt 121 nnlshqeqey lkeycdlitd lksgdlvdid lsgslvppsd vfidvrvlkd ageiqteygv 181 fnlikdsqff vrqsdverli qqgylqki // LOCUS NP_010297 647 aa linear PLN 30-JUN-2025 DEFINITION Rad61p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010297 VERSION NP_010297.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180322.1 REFERENCE 1 (residues 1 to 647) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 647) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 647) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 647) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11860. Method: conceptual translation. FEATURES Location/Qualifiers source 1..647 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..647 /product="Rad61p" /calculated_mol_wt="74591" Region 254..630 /region_name="Wap1" /note="Wap1 domain; pfam16997" /db_xref="CDD:435701" CDS 1..647 /gene="RAD61" /locus_tag="YDR014W" /gene_synonym="WPL1" /coded_by="NM_001180322.1:1..1944" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:18653893]" /experiment="EXISTENCE:genetic interaction:GO:0034183 negative regulation of maintenance of mitotic sister chromatid cohesion [PMID:22901742]" /experiment="EXISTENCE:mutant phenotype:GO:0034183 negative regulation of maintenance of mitotic sister chromatid cohesion [PMID:22901742|PMID:23219725]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:31617566]" /experiment="EXISTENCE:mutant phenotype:GO:0140588 chromatin looping [PMID:32032532]" /experiment="EXISTENCE:mutant phenotype:GO:1902340 negative regulation of chromosome condensation [PMID:23219725]" /note="Subunit of a complex that inhibits sister chromatid cohesion; also negatively regulates chromosome condensation; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; binds Smc3p ATPase head of cohesin; related to the human Wapl protein that controls the association of cohesin with chromatin" /db_xref="GeneID:851577" /db_xref="SGD:S000002421" ORIGIN 1 mraygkrgpv lrtpfrsnkg lpsssdvefs dddvnsvipd vsstisssia dhpiegllde 61 prkaqdssss fdganekpss qldskrndqn vkiitssdts mafmkdekls afnfldgska 121 skrkrrrtyq khdanitssi epdvqdedsi tmhnefesir kiyndinefi lklpradddi 181 lnkmlenemk mddsiennsi rtskdkkygk frtilinknk eneimgeevd qkantlslnn 241 adnsnaekeg ltstnhynel knmgdtikyq ddiefllsns ksndnttvpi neyfkkllnl 301 slmiindeef fqyakryfkk eiiklsfaqf rsdfpelill qgyllhkvse sqsdfppsfd 361 nfsielskdd gkirtkknkh ikklshlnfe dflrktqfkt glyyslslwe mhgnlsldii 421 krisilasnk dlfsrhvktf iplleklita sefchmyieq pemfdslisn lnnqfkdmld 481 ddslikilil ltnmevhnyt lwkeadmifq ssmntilesi hpltdakvdn illhlglcln 541 icsrensrlk ldgklwydmk tifvkmirdg sdtenrlvqg lfylnfsfli kqrkensnld 601 pgelnlllve leafksetsq fnegisnkie ialnylksiy tseriti // LOCUS NP_001035220 162 aa linear PLN 30-JUN-2025 DEFINITION Hed1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001035220 VERSION NP_001035220.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184688.1 REFERENCE 1 (residues 1 to 162) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 162) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 162) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 162) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11861. Method: conceptual translation. FEATURES Location/Qualifiers source 1..162 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..162 /product="Hed1p" /calculated_mol_wt="18127" CDS 1..162 /gene="HED1" /locus_tag="YDR014W-A" /coded_by="NM_001184688.1:1..489" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16818607]" /experiment="EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:18347097]" /experiment="EXISTENCE:direct assay:GO:0045950 negative regulation of mitotic recombination [PMID:16818607]" /experiment="EXISTENCE:direct assay:GO:1903873 negative regulation of DNA recombinase mediator complex assembly [PMID:18347097]" /experiment="EXISTENCE:genetic interaction:GO:0007130 synaptonemal complex assembly [PMID:24367271]" /experiment="EXISTENCE:genetic interaction:GO:0045950 negative regulation of mitotic recombination [PMID:16818607]" /experiment="EXISTENCE:mutant phenotype:GO:0004857 enzyme inhibitor activity [PMID:27483004]" /experiment="EXISTENCE:mutant phenotype:GO:0045950 negative regulation of mitotic recombination [PMID:16818607]" /note="Meiosis-specific protein; down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; promotes synapsis and required for the normal morphogenesis of synaptonemal complex; prevents the recruitment of Rad54p to site-specific DNA double-strand breaks in vivo; early meiotic gene, transcribed specifically during meiotic prophase" /db_xref="GeneID:4036073" /db_xref="SGD:S000113613" ORIGIN 1 mqqrsnrrsc syiplgvhnn aekslcteva parknkrsit tspivninvv errlfnlele 61 kqqlraknls entgggspng gayldakkgv reqdqyqggp skeldrlqpp psmkkspprk 121 kkslkdliye tnktfyqvds nkvkykvgls kkqllpsktv dn // LOCUS NP_010299 94 aa linear PLN 30-JUN-2025 DEFINITION Dad1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010299 VERSION NP_010299.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180324.3 REFERENCE 1 (residues 1 to 94) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 94) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 94) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 94) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11862. On Jul 30, 2012 this sequence version replaced NP_010299.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..94 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..94 /product="Dad1p" /calculated_mol_wt="10385" Region 19..73 /region_name="DASH_Dad1" /note="DASH complex subunit Dad1; pfam08649" /db_xref="CDD:430129" CDS 1..94 /gene="DAD1" /locus_tag="YDR016C" /coded_by="NM_001180324.3:1..285" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:16777964|PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15664196|PMID:15640796]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:20479465|PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479468|PMID:20479465]" /note="Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" /db_xref="GeneID:851579" /db_xref="SGD:S000002423" ORIGIN 1 mmastsndee klisttdkyf ieqrnivlqe inetmnsiln glnglnisle ssiavgrefq 61 svsdlwktly dgleslsdea pideqptlsq sktk // LOCUS NP_010300 1050 aa linear PLN 30-JUN-2025 DEFINITION inositol polyphosphate kinase KCS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010300 VERSION NP_010300.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180325.3 REFERENCE 1 (residues 1 to 1050) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1050) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1050) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1050) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1050) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1050) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1050) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1050) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1050) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11863. On Jul 30, 2012 this sequence version replaced NP_010300.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1050 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1050 /product="inositol polyphosphate kinase KCS1" /EC_number="2.7.4.21" /calculated_mol_wt="119419" Region 759..957 /region_name="IPK" /note="Inositol polyphosphate kinase; pfam03770" /db_xref="CDD:397715" CDS 1..1050 /gene="KCS1" /locus_tag="YDR017C" /coded_by="NM_001180325.3:1..3153" /experiment="EXISTENCE:direct assay:GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity [PMID:10827188]" /experiment="EXISTENCE:direct assay:GO:0000828 inositol hexakisphosphate kinase activity [PMID:11956213|PMID:10574768]" /experiment="EXISTENCE:direct assay:GO:0000829 diphosphoinositol pentakisphosphate kinase activity [PMID:11956213]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032958 inositol phosphate biosynthetic process [PMID:17412958|PMID:10574768]" /experiment="EXISTENCE:mutant phenotype:GO:0010919 regulation of inositol phosphate biosynthetic process [PMID:23824185]" /experiment="EXISTENCE:mutant phenotype:GO:0030643 intracellular phosphate ion homeostasis [PMID:15866881]" /experiment="EXISTENCE:mutant phenotype:GO:0032958 inositol phosphate biosynthetic process [PMID:11956213]" /note="Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response, RNA polymerase I-mediated rRNA transcription and telomere maintenance; phosphorylated by the AMPK Snf1p, leading to reduced levels of pyrophosphorylated IP7, increased filamentous and invasive growth and increased cell elongation" /db_xref="GeneID:851580" /db_xref="SGD:S000002424" ORIGIN 1 mdtsheihdk ipdtlreqqq hlrqkesegc ittlkdlnvp etkklssvlh grkastylri 61 frddecladn nngvdsnngg svtcadkitr seatpksvpe glqvsekknn pdtlssslss 121 filsnheepa ikpnkhvahr nnitetgqgs gediakqqsh qpqvlhhqts lkpiqnvdeg 181 cispkstyqe slhgisedlt lkpvssatyy phkskadsgy eekdkmendi dtiqpatinc 241 asgiatlpss ynrhtfkvkt ystlsqslrq envnnrsnek kpqqfvphse sikekpntfe 301 qdkegeqade eedegdnehr eyplavelkp ftnrvgghta ifrfskravc kalvnrenrw 361 yenielchke llqfmpryig vlnvrqhfqs kddflsdldq enngkndtsn enkdievnhn 421 nnddialnte ptgtplthih sfplehssrq vlekehpeie svhphvkrsl sssnqpsllp 481 evvlndnrhi ipeslwykys dspnsapnds yfssssshns csfgergntn klkrrdsgst 541 mintelknlv irevfapkcf rrkrnsnttt mgnhnarlgs spsfltqksr asshdasnts 601 mktlgdsssq aslqmddskv npnlqdpflk kslhekisna ldgshsvmdl kqfhkneqik 661 hknsfcnsls piltatnsrd dgefatspny isnaqdgvfd mdedtgneti nmdnhgchld 721 sgknmiiksl aynvsndysh hdiesitfee tshtivskfi lledltrnmn kpcaldlkmg 781 trqygvdakr akqlsqrakc lkttsrrlgv ricglkvwnk dyyitrdkyf grrvkvgwqf 841 arvlarflyd gktieslirq iprlikqldt lyseifnlkg yrlygaslll mydgdanksn 901 skrkkaanvk vnlidfarcv tkedamecmd kfrippkspn iedkgflrgv kslrfyllli 961 wnyltsdmpl ifdevemndm iseeadsnsf tsatgskinf nskwdwldef dkedeemynd 1021 pnsklrqkwr kyelifdaep rynddaqvsd // LOCUS NP_010301 396 aa linear PLN 30-JUN-2025 DEFINITION putative acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010301 VERSION NP_010301.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180326.1 REFERENCE 1 (residues 1 to 396) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 396) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 396) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 396) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11864. Method: conceptual translation. FEATURES Location/Qualifiers source 1..396 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..396 /product="putative acyltransferase" /calculated_mol_wt="45808" Region 102..308 /region_name="LPLAT_LCLAT1-like" /note="Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; cd07990" /db_xref="CDD:153252" Site order(117,120,122,143..146,218..220) /site_type="active" /note="putative acyl-acceptor binding pocket [active]" /db_xref="CDD:153252" Region 300..>347 /region_name="Acyltransf_C" /note="Acyltransferase C-terminus; pfam16076" /db_xref="CDD:465006" CDS 1..396 /gene="MLG1" /locus_tag="YDR018C" /coded_by="NM_001180326.1:1..1191" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006654 phosphatidic acid biosynthetic process [PMID:38297966]" /experiment="EXISTENCE:direct assay:GO:0042171 lysophosphatidic acid acyltransferase activity [PMID:38297966]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:38297966]" /experiment="EXISTENCE:mutant phenotype:GO:0036150 phosphatidylserine acyl-chain remodeling [PMID:38297966]" /experiment="EXISTENCE:mutant phenotype:GO:0036152 phosphatidylethanolamine acyl-chain remodeling [PMID:38297966]" /note="Lysolipid acyltransferase; involved in the synthesis of phosphatidic acid from 1-acyl-2-hydroxy-sn-glycero-3-phosphate using oleoyl-CoA as acyl donor and in phospholipid remodeling, incorporating palmitic acid into the sn-1 position of phosphatidylserine and phosphatidylethanolamine; localizes to ER membranes associated with mitochondria (MAMs); contains three predicted transmembrane domains; similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase" /db_xref="GeneID:851581" /db_xref="SGD:S000002425" ORIGIN 1 mkhsqkyrry giyektgnpf ikglqrllia clfisgslsi vvfqiclqvl lpwskirfqn 61 ginqskkafi vllcmilnmv apsslnvtfe tsrplknssn akpcfrfkdr aiiianhqmy 121 adwiylwwls fvsnlggnvy iilkkalqyi pllgfgmrnf kfiflsrnwq kdekaltnsl 181 vsmdlnarck gpltnykscy sktnesiaay nlimfpegtn lslktrekse afcqrahldh 241 vqlrhlllph skglkfavek lapsldaiyd vtigyspalr teyvgtkftl kkiflmgvyp 301 ekvdfyiref rvneiplqdd evffnwllgv wkekdqlled yyntgqfksn akndnqsivv 361 ttqttgfqhe tltprilsyy gffaflilvf vmkknh // LOCUS NP_010302 400 aa linear PLN 30-JUN-2025 DEFINITION glycine decarboxylase subunit T [Saccharomyces cerevisiae S288C]. ACCESSION NP_010302 VERSION NP_010302.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180327.1 REFERENCE 1 (residues 1 to 400) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 400) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 400) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 400) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11865. Method: conceptual translation. FEATURES Location/Qualifiers source 1..400 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..400 /product="glycine decarboxylase subunit T" /EC_number="2.1.2.10" /calculated_mol_wt="44338" Region 16..395 /region_name="gcvT" /note="glycine cleavage system T protein; TIGR00528" /db_xref="CDD:273121" CDS 1..400 /gene="GCV1" /locus_tag="YDR019C" /gene_synonym="GSD1" /coded_by="NM_001180327.1:1..1203" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0006730 one-carbon metabolic process [PMID:10871621]" /experiment="EXISTENCE:mutant phenotype:GO:0005960 glycine cleavage complex [PMID:9047339]" /experiment="EXISTENCE:mutant phenotype:GO:0006544 glycine metabolic process [PMID:9047339]" /experiment="EXISTENCE:mutant phenotype:GO:0006730 one-carbon metabolic process [PMID:10871621]" /note="T subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm" /db_xref="GeneID:851582" /db_xref="SGD:S000002426" ORIGIN 1 msiikkivfk rfnstlkkta lhdlhvslgg tmvpyagysm pvlykgqthi eshnwtrtna 61 glfdvshmlq sklsgphsvk flqrvtptdf nalpvgsgtl svllnpqggv vddtiitken 121 ddnefyivtn agcaerdtef fhdelqngst ldcqwkiieg rsllalqgpk akdvleplls 181 ktapgkdlke lffgqrhefa lkdgslvqia rggytgedgf eisianekav efaeqllanp 241 vmkpiglaar dslrleagmc lygheldesi tpveaalnwv isksrrdlvd qkywfngyak 301 imdqlnnkty skvrvgfkyl kkgpaarngv kiflpdaete vglvtsgsas ptlnninigq 361 ayvqkgyhkk gtkllvqvrn kfypielakm plvpthyykq // LOCUS NP_010303 232 aa linear PLN 30-JUN-2025 DEFINITION putative uridine kinase DAS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010303 VERSION NP_010303.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180328.3 REFERENCE 1 (residues 1 to 232) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 232) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 232) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 232) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11866. On Jul 30, 2012 this sequence version replaced NP_010303.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..232 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..232 /product="putative uridine kinase DAS2" /EC_number="2.7.1.48" /calculated_mol_wt="26464" Region 12..196 /region_name="NK" /note="Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; cl17190" /db_xref="CDD:450170" Site order(17,22..25) /site_type="active" /db_xref="CDD:238981" CDS 1..232 /gene="DAS2" /locus_tag="YDR020C" /gene_synonym="RRT3" /coded_by="NM_001180328.3:1..699" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases" /db_xref="GeneID:851583" /db_xref="SGD:S000002427" ORIGIN 1 mdrkaveekr ivisigggha tgvgaialdl qntfkslyns inirvinldn miegniksyn 61 nndydfdnil nlvyekhavt sqndmiqhdy edpidliivc gcyalydkri neisqlkvfl 121 dsdadkrlis likkknvgsn eqlaqlitey mdhlrpemqq yieptrtfad liipstnenl 181 gravlvdgiv kaiedtksqi egnntnnkir prlwdfeaet mdlekdryyd ls // LOCUS NP_010304 399 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase FAL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010304 VERSION NP_010304.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180329.3 REFERENCE 1 (residues 1 to 399) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 399) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 399) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 399) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11867. On Jul 30, 2012 this sequence version replaced NP_010304.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..399 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..399 /product="ATP-dependent RNA helicase FAL1" /EC_number="3.6.4.13" /calculated_mol_wt="45082" Region 20..398 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Site order(69..75,173) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:350670" CDS 1..399 /gene="FAL1" /locus_tag="YDR021W" /coded_by="NM_001180329.3:1..1200" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9372960]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16449634]" /experiment="EXISTENCE:physical interaction:GO:0097078 FAL1-SGD1 complex [PMID:21576267]" /note="Nucleolar protein required for maturation of 18S rRNA; member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases; 18S rRNA biogenesis defect of the null mutant is functionally complemented by human EIF4A3" /db_xref="GeneID:851584" /db_xref="SGD:S000002428" ORIGIN 1 msfdreedqk lkfktskklk vsstfesmnl kddllrgiys ygfeapssiq sraitqiisg 61 kdviaqaqsg tgktatftig llqaidlrkk dlqalilspt relasqigqv vknlgdymnv 121 nafaitggkt lkddlkkmqk hgcqavsgtp grvldmikkq mlqtrnvqml vldeadells 181 etlgfkqqiy difaklpknc qvvvvsatmn kdilevtrkf mndpvkilvk rdeislegik 241 qyvvnvdkee wkfdtlcdiy dsltitqcvi fcntkkkvdw lsqrliqsnf avvsmhgdmk 301 qeerdkvmnd frtghsrvli stdvwargid vqqvslviny dlpeiienyi hrigrsgrfg 361 rkgvainfit kadlaklrei ekfysikinp mpanfaels // LOCUS NP_010305 196 aa linear PLN 30-JUN-2025 DEFINITION Atg31p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010305 VERSION NP_010305.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180330.1 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11868. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..196 /product="Atg31p" /calculated_mol_wt="22060" Region 2..196 /region_name="ATG31" /note="Autophagy-related protein 31; pfam09795" /db_xref="CDD:401667" CDS 1..196 /gene="ATG31" /locus_tag="YDR022C" /gene_synonym="CIS1" /coded_by="NM_001180330.1:1..591" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:17362880|PMID:18497569]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990316 Atg1/ULK1 kinase complex [PMID:26753620]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:17362880]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /note="Autophagy-specific protein required for autophagosome formation; forms a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; constitutively phosphorylated, and phosphorylation of residue S174 is required for function; high-copy suppressor of CIK1 deletion" /db_xref="GeneID:851585" /db_xref="SGD:S000002429" ORIGIN 1 mnvtvtvydk nvkyrleeni knnkgpsndd qpaynnesks tdgsdyamfp tnikyifedn 61 ndelvdssda altagidkvg delenviivq ldesgsledi tlisdqyell shrtnslsle 121 enqmrtlssh gddksndeee elsvdsdrfr vdsdieldvi sqfcdlspfl rdlslndlik 181 lyvtqneqlq mlsnsv // LOCUS NP_010306 462 aa linear PLN 30-JUN-2025 DEFINITION serine--tRNA ligase SES1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010306 VERSION NP_010306.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180331.1 REFERENCE 1 (residues 1 to 462) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 462) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 462) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 462) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11869. Method: conceptual translation. FEATURES Location/Qualifiers source 1..462 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..462 /product="serine--tRNA ligase SES1" /EC_number="6.1.1.11" /calculated_mol_wt="53179" Region 1..449 /region_name="PLN02678" /note="seryl-tRNA synthetase" /db_xref="CDD:215364" CDS 1..462 /gene="SES1" /locus_tag="YDR023W" /coded_by="NM_001180331.1:1..1389" /experiment="EXISTENCE:direct assay:GO:0004828 serine-tRNA ligase activity [PMID:3031581]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006434 seryl-tRNA aminoacylation [PMID:3031581]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0110004 positive regulation of tRNA methylation [PMID:28003514]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate; copurifies with Abp140p in an RNA-dependent manner and stimulates 3-methylcytidine (m3C) modification of residue 32 of the tRNA anticodon loop of tRNA-Ser; interacts with peroxin Pex21p" /db_xref="GeneID:851587" /db_xref="SGD:S000002430" ORIGIN 1 mldinqfied kggnpelirq sqkarnasve ivdeiisdyk dwvktrfeld elnkkfnklq 61 kdiglkfknk edasgllaek ekltqqkkel tekeqqedkd lkkkvfqvgn ivhpsvvvsn 121 deennelvrt wkpedleavg piasvtgkpa slshheillr ldgydpdrgv kicghrgyff 181 rnygvflnqa linyglqfla akgyiplqap vmmnkelmsk taqlsefdee lykvidgede 241 kyliatseqp isayhsgewf ekpqeqlpih yvgysscfrr eagshgkdaw gvfrvhafek 301 ieqfvitepe ksweefekmi syseefyksl klpyrivgiv sgelnnaaak kydleawfpy 361 qkeykelvsc snctdyqsrn leircgikkm gdrekkyvhc lnstlaatqr alccilenyq 421 tedglvvpev lrkyipgepe flpfvnelpk nstsskdkkk kn // LOCUS NP_010308 156 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS17 RPS11A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010308 VERSION NP_010308.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180333.3 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11870. On Jul 30, 2012 this sequence version replaced NP_010308.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..156 /product="40S ribosomal protein uS17 RPS11A" /calculated_mol_wt="17618" Region 4..156 /region_name="PTZ00241" /note="40S ribosomal protein S11; Provisional" /db_xref="CDD:240326" CDS 1..156 /gene="RPS11A" /locus_tag="YDR025W" /coded_by="NM_001180333.3:1..471" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:8070651]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S11 and bacterial S17; N-terminally propionylated in vivo; RPS11A has a paralog, RPS11B, that arose from the whole genome duplication" /db_xref="GeneID:851589" /db_xref="SGD:S000002432" ORIGIN 1 msteltvqse rafqkqphif nnpkvktskr tkrwyknagl gfktpktaie gsyidkkcpf 61 tglvsirgki ltgtvvstkm hrtivirray lhyipkynry ekrhknvpvh vspafrvqvg 121 divtvgqcrp isktvrfnvv kvsaaagkan kqfakf // LOCUS NP_010309 570 aa linear PLN 30-JUN-2025 DEFINITION Nsi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010309 VERSION NP_010309.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180334.3 REFERENCE 1 (residues 1 to 570) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 570) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 570) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 570) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11871. On Jul 30, 2012 this sequence version replaced NP_010309.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..570 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..570 /product="Nsi1p" /calculated_mol_wt="66221" Region 53..567 /region_name="REB1" /note="Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]; COG5147" /db_xref="CDD:227476" CDS 1..570 /gene="NSI1" /locus_tag="YDR026C" /gene_synonym="YTT1" /coded_by="NM_001180334.3:1..1713" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:25092870]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22362748|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006363 termination of RNA polymerase I transcription [PMID:22805593]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:22362748]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:22362748]" /experiment="EXISTENCE:mutant phenotype:GO:0006363 termination of RNA polymerase I transcription [PMID:22805593]" /note="RNA polymerase I termination factor; binds to rDNA terminator element, required for efficient Pol I termination; required for rDNA silencing at NTS1; facilities association of Sir2p with NTS1, contributes to rDNA stability and cell longevity; interacts physically with Fob1p and RENT subunits, Sir2p and Net1p; may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein; NSI1 has a paralog, REB1, that arose from the whole genome duplication" /db_xref="GeneID:851590" /db_xref="SGD:S000002433" ORIGIN 1 mdsvsnlkst nfqnnndpke sveeavlryv gvdlknhikk tkkklkkqkk rkhgskmshe 61 dedtdmdwyl ktsgskdlrk vddiepnsva vaavaaayns smrekdkrsc hkkssnsrse 121 rkkhrkrkss kerkakikmv ldpqlttldd gitttaflpd dliaetafdk yvdtekayla 181 khpskslevn eddkennfnn nsstlvriyt dlegipndgs yikrtpkipe kdvksddlil 241 apeenngdta llrsdivkas vidgaitksi gkkftpseen aldqfieeym kirgldrrqm 301 ceriwstdgv irdgfwanis kvlpyrtrss iykhirrkyh ifeqrgkwtp eedqelarlc 361 lekeghwtev gkllgrmped crdrwrnymk cgskrgskrw skeeeelltt vvnemieeah 421 qyqrmkalea ankndrynqm ysrgpkgkri sdnptfkdmi nwtvvserms gtrsriqcry 481 kwnklvtdea arsmlsipvs erkwllerlk qlpktsysni dwnsiatykp gyprtglelr 541 lcyeqmreki hdfkgrstae iidslleqin // LOCUS NP_010310 889 aa linear PLN 30-JUN-2025 DEFINITION Vps54p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010310 VERSION NP_010310.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180335.1 REFERENCE 1 (residues 1 to 889) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 889) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 889) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 889) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11872. Method: conceptual translation. FEATURES Location/Qualifiers source 1..889 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..889 /product="Vps54p" /calculated_mol_wt="101389" CDS 1..889 /gene="VPS54" /locus_tag="YDR027C" /gene_synonym="CGP1; LUV1; TCS3" /coded_by="NM_001180335.1:1..2670" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:10637310]" /experiment="EXISTENCE:direct assay:GO:0042147 retrograde transport, endosome to Golgi [PMID:12686613]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:10637310]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:17645731]" /experiment="EXISTENCE:mutant phenotype:GO:0090156 intracellular sphingolipid homeostasis [PMID:26357016]" /experiment="EXISTENCE:physical interaction:GO:0000938 GARP complex [PMID:10637310]" /note="Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; potentially phosphorylated by Cdc28p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p" /db_xref="GeneID:851591" /db_xref="SGD:S000002434" ORIGIN 1 msisetphnk sqglqkaagr pkivvpegsp srnsdsgsft iegdtslndd llsisgsvtp 61 rarrssrlsl dsitprrsfd srtlsvansr sfgfeneths gsmdfsplgn nsiyeivmnt 121 rrknwlnypt vadipqvsls kndlddhwkt hvieyvknik sdyqifqstn nirnmnqmeq 181 lkelregenm heesfeanlr qgdaelinsi pdfyfsdkfq ldnprtfhkv ldaidlfltk 241 ldmkrqaerd eafselrdrl ndfldivetl lvteiskssh kffhalsevd niqkraldtm 301 selkelaqni ktidaenirk kishlemifk rknvekleqg llqaklvlnk tdecksmyee 361 nkldncleli ksidylikgd dsinedvqsw trcwpyklsn lrtipalsat refltnmkie 421 iggkfslqls illiddlrsf cksikpketl hriqtgsndk kqtiftdnfs skitelivrl 481 nrceeltsaf dlyreksite lksiikiylp tenahadnnh dekhlnngst sgsklsrlik 541 eqtpaefqsm lvnifthale alrrlyghqk llldislnel asvkspnenq hnmitqldir 601 tgineiirii qlrtgkiiav rrelnlslry dyflkfyaic vifiqecevl sgefltkyls 661 nvlasqikhy anaqssknyr nikkkidaee wipyivdssi qsdvndivss ididplswtt 721 ildmvggshd cengrsedke kdegnetyqg hrksvvvgdk tfvassslla tievikelmv 781 lsinlpsiyl snfeklcyda lqyynssama svtqpgnsll ktgrnlsimg esldclaefv 841 iivqrfyqrl snsnrdfepf dashyttllg qfqassnkiy manappppv // LOCUS NP_010311 1014 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase regulator REG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010311 VERSION NP_010311.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180336.1 REFERENCE 1 (residues 1 to 1014) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1014) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1014) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1014) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11873. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1014 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1014 /product="protein phosphatase regulator REG1" /calculated_mol_wt="112485" Region 173..204 /region_name="DUF1752" /note="Fungal protein of unknown function (DUF1752); pfam08550" /db_xref="CDD:430068" CDS 1..1014 /gene="REG1" /locus_tag="YDR028C" /gene_synonym="HEX2; PZF240; SPP43; SRN1" /coded_by="NM_001180336.1:1..3045" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10454550]" /experiment="EXISTENCE:direct assay:GO:0007039 protein catabolic process in the vacuole [PMID:14684743]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:25730376]" /experiment="EXISTENCE:mutant phenotype:GO:0007039 protein catabolic process in the vacuole [PMID:14684743]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:19723765]" /note="Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; REG1 has a paralog, REG2, that arose from the whole genome duplication" /db_xref="GeneID:851592" /db_xref="SGD:S000002435" ORIGIN 1 mstnlanyfa gkkdienehv nrnashesns ksdvkisgnd ndndedmgps vsmavqaknd 61 ddfhkstfnl krtrsmglld eyidptkkll grsddlydnd neyydnssnn sssnssdddy 121 ddgyqehsts vspppadnds ylipqddndv vveperhvdy lshewkesei snswkyiilk 181 kkkrdvdlvn aarlenaswr twakarnnlk tvspevvnws kdsdvtwlyg pivrdsegna 241 qseeehdler gygsddensk rismptknsk siaaapkpil kkrtvteiie dnalwklnea 301 rkhmtemkha svimdpngnk nvhddfdala aqvnaqyyhy pkesnssvsl ksqhsdkkdn 361 stipnpvgen sngggdkgee dlhlksalhv qnnrstaqsn ksilenstnd rkanldqnln 421 spdnnrfpss tsssnrdnen nsmglssilt snpseksnkp tknrhihfnd rveqcmalry 481 pasqseddes ddenkqyvdv nnnanvttin nnrtpllaiq hksipinsat ehlnkntsdd 541 dtssqsssss hsddeehggl yinarfsrrs dsgvhspitd nssvasstts rahvrpiikl 601 lpdttlnygs deesdngefn gygnavshnv ntsrgydyiy dynsvytgdt ssflpvdscd 661 ivdvpegmdl qtaiaddnas nyefnnaves kekhvpqlhk asannttrqh gshmllyddd 721 nyssssdseq qfiedsqyns sddeeeeddd dqevddnhde glslrrtlsl gksgstnsly 781 dlaqpslssa tpqqknptnf tggktdvdkd aqlavrpypl krnsssgnfi fnsdseeess 841 seeeqrplpa nsqlvnrsvl kgsvtpanis sqkkkalpkq pkasdssqsf rivnntpspa 901 evgasdvaie gyfsprnesi ksvvsggnmm dhqdhsemdt lakgfenchi nnasklkdkk 961 vdsvqttrke asltdssnes lhkvvqnarg maskylhswk ksdvkpqeng ndss // LOCUS NP_001335755 104 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR029W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335755 VERSION NP_001335755.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348809.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80275. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..104 /product="uncharacterized protein" /calculated_mol_wt="12180" CDS 1..104 /locus_tag="YDR029W" /coded_by="NM_001348809.1:1..315" /note="hypothetical protein; conserved among S. cerevisiae strains; YDR029W is not an essential gene" /db_xref="GeneID:851593" /db_xref="SGD:S000002436" ORIGIN 1 mskyyiliel mndkkntnss cdifsfylnf sdnpfssfrl ksrllygifs cfllfyslkd 61 ligvfkqkyl ylsilllwll vllfclakgl shnlradsfl qypl // LOCUS NP_010313 506 aa linear PLN 30-JUN-2025 DEFINITION Rad28p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010313 VERSION NP_010313.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180338.3 REFERENCE 1 (residues 1 to 506) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 506) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 506) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 506) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11874. On Jul 30, 2012 this sequence version replaced NP_010313.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..506 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..506 /product="Rad28p" /calculated_mol_wt="58100" Region 61..102 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 108..170 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <190..387 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 198..233 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 241..279 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 290..351 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 362..388 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..506 /gene="RAD28" /locus_tag="YDR030C" /coded_by="NM_001180338.3:1..1521" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:8830695]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:8830695]" /note="Protein involved in DNA repair; related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair" /db_xref="GeneID:851594" /db_xref="SGD:S000002437" ORIGIN 1 mdpflefrvg nislnefyrr tiqseferil edplsnmkny rfskqsnyst kektplsigv 61 ncldiddtgq vllgggddgs lsiwgldesl hrndegeqel inkrlnyikr qphqsddepa 121 qimgyknkrt rindnntmrl vhsfqtqrnk yrmyrqssaa vpvqrshisn ktdspigfse 181 tlsetdseas ishhkygitt lkwykadngm fftgsndktv kiwdtnrfea vqdinlgyki 241 nqidnnvvdd ssllvvased yyprlidlrt mnsgvtalgm gnqtrmqsei lcckfnpvre 301 qiiacgdmeg gvklwdlrmr nrlyselkrn knrfktinnd dnddqsdvyf ssnqskahlr 361 ccsdivwnse gselcsvgmd gklnvwrpft eilqpeglas ysqlgtqdls rikykkrvsr 421 rllwfdkfll citdngevei ynteekklwn kleypmvnqv kknqashcqf ssmivqtnim 481 nsvglklffg tnnntvsdgg sifecs // LOCUS NP_010314 121 aa linear PLN 30-JUN-2025 DEFINITION Mix14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010314 VERSION NP_010314.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180339.3 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11875. On Jul 30, 2012 this sequence version replaced NP_010314.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..121 /product="Mix14p" /calculated_mol_wt="13735" Region 12..53 /region_name="CX9C" /note="CHCH-CHCH-like Cx9C, IMS import disulfide relay-system; pfam16860" /db_xref="CDD:465284" CDS 1..121 /gene="MIX14" /locus_tag="YDR031W" /gene_synonym="MIC14" /coded_by="NM_001180339.3:1..366" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:17095012]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:19703468]" /note="Mitochondrial intermembrane space hypothetical protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851595" /db_xref="SGD:S000002438" ORIGIN 1 msdildeivi edvvancpqe flqyhkcird neenpgkckd grmilstcir ekvpsvksim 61 secsepmkky dqcirdnmgt rtinenclgf lqdlrkcael qvknknikps ingvnlelik 121 d // LOCUS NP_010315 198 aa linear PLN 30-JUN-2025 DEFINITION flavodoxin-like fold family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010315 VERSION NP_010315.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180340.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11876. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..198 /product="flavodoxin-like fold family protein" /calculated_mol_wt="20835" Region 1..197 /region_name="FMN_red" /note="NADPH-dependent FMN reductase; cl00438" /db_xref="CDD:469770" CDS 1..198 /gene="PST2" /locus_tag="YDR032C" /coded_by="NM_001180340.1:1..597" /experiment="EXISTENCE:direct assay:GO:0003955 NAD(P)H dehydrogenase (quinone) activity [PMID:28499769]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:38096056]" /experiment="EXISTENCE:mutant phenotype:GO:0160020 positive regulation of ferroptosis [PMID:38096056]" /note="FMN-dependent NAD(P)H:quinone oxidoreductase; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication" /db_xref="GeneID:851596" /db_xref="SGD:S000002439" ORIGIN 1 mprvaiiiyt lyghvaatae aekkgieaag gsadiyqvee tlspevvkal ggapkpdypi 61 atqdtlteyd aflfgiptrf gnfpaqwkaf wdrtgglwak galhgkvagc fvstgtgggn 121 eatimnslst lahhgiifvp lgyknvfael tnmdevhggs pwgagtiags dgsrspsale 181 lqvheiqgkt fyetvakf // LOCUS NP_010316 320 aa linear PLN 30-JUN-2025 DEFINITION Mrh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010316 VERSION NP_010316.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180341.1 REFERENCE 1 (residues 1 to 320) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 320) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 320) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 320) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11877. Method: conceptual translation. FEATURES Location/Qualifiers source 1..320 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..320 /product="Mrh1p" /calculated_mol_wt="36060" Region 30..260 /region_name="7tm_YRO2_fungal-like" /note="fungal YRO2 and related proteins, member of the seven-transmembrane GPCR superfamily; cd15239" /db_xref="CDD:320367" Region 31..56 /region_name="TM helix 1" /note="TM helix 1 [structural motif]" /db_xref="CDD:320367" Region 62..84 /region_name="TM helix 2" /note="TM helix 2 [structural motif]" /db_xref="CDD:320367" Region 114..136 /region_name="TM helix 3" /note="TM helix 3 [structural motif]" /db_xref="CDD:320367" Site order(120,123..124,152,156,171,174..175,178,215,219..220, 223,245,248..249) /site_type="other" /note="putative ligand binding site [chemical binding]" /db_xref="CDD:320367" Region 140..160 /region_name="TM helix 4" /note="TM helix 4 [structural motif]" /db_xref="CDD:320367" Region 167..191 /region_name="TM helix 5" /note="TM helix 5 [structural motif]" /db_xref="CDD:320367" Region 198..226 /region_name="TM helix 6" /note="TM helix 6 [structural motif]" /db_xref="CDD:320367" Region 235..260 /region_name="TM helix 7" /note="TM helix 7 [structural motif]" /db_xref="CDD:320367" CDS 1..320 /gene="MRH1" /locus_tag="YDR033W" /coded_by="NM_001180341.1:1..963" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10675524|PMID:12469340|PMID:16622836]" /note="Protein that localizes primarily to the plasma membrane; also found at the nuclear envelope; long-lived protein that is asymmetrically retained in the plasma membrane of mother cells; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; null mutation confers sensitivity to acetic acid" /db_xref="GeneID:851597" /db_xref="SGD:S000002440" ORIGIN 1 mstfetlikr ggneaikinp ptgadfhits rgsdwfwtcf ccyllfglil tflmfrkpvn 61 drffyltgia pnffmciayf tmasnlgwip vkakynhvqt stqkehpgyr qifysrfvgw 121 flalpwpiiq icmlagtpfw qmafnvcite fftvcwliaa cvhstykwgy ytiglgaaiv 181 vsisvmttsy nlvkqrdndi rltflvffsi imflwiiayp tcfgitdggn vlqpdsagif 241 ygiidlilmc fiptllvpia nhfgadklgy hfgpsdaeav mapkapvasp rpaatpnlsk 301 dkkkkskksk kskkskksee // LOCUS NP_010317 790 aa linear PLN 30-JUN-2025 DEFINITION Lys14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010317 VERSION NP_010317.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180342.3 REFERENCE 1 (residues 1 to 790) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 790) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 790) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 790) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11878. On Jul 30, 2012 this sequence version replaced NP_010317.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..790 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..790 /product="Lys14p" /calculated_mol_wt="89266" Region 153..195 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(158,163..166,168,171,181) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(159,162,169,176,179,186) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 359..773 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cl23766" /db_xref="CDD:419994" CDS 1..790 /gene="LYS14" /locus_tag="YDR034C" /coded_by="NM_001180342.3:1..2373" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9701810]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10975256]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11952910|PMID:7935367]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3123231]" /experiment="EXISTENCE:mutant phenotype:GO:2001196 positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine [PMID:3123231]" /note="Transcriptional activator involved in regulating lysine biosynthesis; involved in the regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer" /db_xref="GeneID:851598" /db_xref="SGD:S000002441" ORIGIN 1 mfesvnlden spedrelakv lsppgsylsp asldsgssft nsgtstscfe pknnlpslsf 61 lnaragslgg ifnhkqmtsp snsniggenv esttssndgs nenaghptts eqdqnadhpt 121 isqaddnghs sltpnpavts tvtdkkgntv krkysrngcs eckrrrmkcd etkptcwqca 181 rlnrqcvyvl npknkkrrts naqrvkefrk hstsldndhn narkrqhssc kaekkkkvrq 241 nlsedttdpk pitdngknvp ldeiesleip nldltttmng ydvnllmqnl ndmvnmklhd 301 syllneelkg ldlpdldipe llpasnvnss vpisflvnnv itfntklssf klggihdkyl 361 kifyydclds iapffqnqgn plrdillsfa kneayllssi latgasiayr ksnnledern 421 ycaylshcls llgeqfknes nvlnriepii ltvimlawdc iysmnsqwrs hlkgvtdlfk 481 kinagnsskv lnvakcwfkv metfasistv fggslidnnd ldaifdpydy qyvdslkfln 541 imtplnefnl lrghkedfdl vikevfksln tirsteknyf skeeglftkk ldylllssqt 601 ssekskdqis yfntqkilve idkqldyefi dksgiipsdn qshprisnih dnaidmvtlk 661 ngeevaiswy dishqtqvls fllivllkll gmpkesstiq qvvkkimsff kfldsdsppq 721 nsrtcysnfa vliaglnamd eetraivkry ykinggkfqk ltehnlnrle kvwygknqny 781 rleeqdvltw // LOCUS NP_058138 1770 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058138 VERSION NP_058138.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184379.4 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11879. On Jul 30, 2012 this sequence version replaced NP_058138.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1770 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="201835" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 574..641 /region_name="gag_pre-integrs" /note="GAG-pre-integrase domain; pfam13976" /db_xref="CDD:372857" Region 660..761 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1285..>1468 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1621..1757 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1625..1628,1662..1664,1667,1700,1727,1754) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1770 /locus_tag="YDR034C-D" /coded_by="join(NM_001184379.4:1..1293, NM_001184379.4:1295..5314)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:851599" /db_xref="SGD:S000007345" ORIGIN 1 mesqqlsqns pnlhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidlknq hseipqaktk vgnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyqrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lgqqqkeskp thtidsndel pdhllidsga sqtlvrsahy lhhatpnsei 481 nivdaqkqdi pinaignlhf nfqngtktsi kalhtpniay dllslselan qnitacftrn 541 tlersdgtvl apivkhgdfy wlskkylips hiskltinnv nksksvnkyp yplihrmlgh 601 anfrsiqksl kknavtylke sdiewsnast yqcpdcligk stkhrhvkgs rlkyqesyep 661 fqylhtdifg pvhhlpksap syfisftdek trfqwvyplh drreesilnv ftsilafikn 721 qfnarvlviq mdrgseytnk tlhkfftnrg itacytttad srahgvaerl nrtllndcrt 781 llhcsglpnh lwfsavefst iirnslvspk ndksarqhag lagldittil pfgqpvivnn 841 hnpdskihpr gipgyalhps rnsygyiiyl pslkktvdtt nyvilqdkqs kldqfnydtl 901 tfdddlnrlt ahnqsfiekn eteqsydqnt esdhdyqsei einsdplvnd fssqsinplq 961 ldkepvqkvr apkevdadis eynilpstir srtphiinke stemggties dttsprhsst 1021 ftarnqkrpg spndmidlts qdrvnyglen ikttrlggte epyiqrnsdt nikyrttnst 1081 psiddrssns esttpiisie tkaacdntps idtdppeyrs sdhatpnimp dkssknvtad 1141 silddlplpd ltnksptdts dvskdiphih srqtnsslgg mddsnvlttt kskkrsledn 1201 eteievsrdt wnnknmrsle pprskkrinl iaaikgvksi kpvrttlryd eaitynednk 1261 ekdryieayh keinqllrmn twdtnkyydr ndidpkkvin smfifnkkrd gthkarfvar 1321 gdiqhpdtyd sdmqsntvhh yalmtslsia ldndyyitql dissaylyad ikeelyirpp 1381 phlglndkll rlrkslyglk qsganwyeti ksylinccdm qevrgwscvf knsqvticlf 1441 vddmilfskd lnankkiitt lkkqydtkii nlgegdneiq ydilgleiky qrskymklgm 1501 ekslteklpk lnvplnpkgk klrapgqpgh yidqdeleid edeykekvhe mqkliglasy 1561 vgykfrfdll yyintlaqhi lfpsrqvldm tyeliqfmwd trdkqliwhk nkptkpdnkl 1621 vaisdasygn qpyyksqign ifllngkvig gkstkasltc tstteaeiha vseaipllnn 1681 lshlvqelnk kpiikglltd srstisiiks tneekfrnrf fgtkamrlrd evsgnnlyvy 1741 yietkkniad vmtkplpikt fklltnkwih // LOCUS NP_058139 438 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058139 VERSION NP_058139.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184378.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11880. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..438 /product="gag protein" /calculated_mol_wt="49558" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..438 /locus_tag="YDR034C-C" /coded_by="NM_001184378.1:1..1317" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:851600" /db_xref="SGD:S000007344" ORIGIN 1 mesqqlsqns pnlhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidlknq hseipqaktk vgnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyqrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lrpateri // LOCUS NP_010318 58 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR034C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010318 VERSION NP_010318.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184326.1 REFERENCE 1 (residues 1 to 58) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 58) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 58) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 58) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11881. Method: conceptual translation. FEATURES Location/Qualifiers source 1..58 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..58 /product="uncharacterized protein" /calculated_mol_wt="6377" CDS 1..58 /locus_tag="YDR034C-A" /coded_by="NM_001184326.1:1..177" /note="hypothetical protein; contained within the solo Ty1 LTR element YDRWdelta7" /db_xref="GeneID:851602" /db_xref="SGD:S000007233" ORIGIN 1 mesiflhani tiiphsvlyv slsyyiinpc vsvstnlddy fssfvsssnt vydnilvt // LOCUS NP_010319 51 aa linear PLN 30-JUN-2025 DEFINITION cysteine-rich palmitoylated domain-containing protein CPP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010319 VERSION NP_010319.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184327.3 REFERENCE 1 (residues 1 to 51) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 51) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 51) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 51) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11882. On Jul 30, 2012 this sequence version replaced NP_010319.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..51 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..51 /product="cysteine-rich palmitoylated domain-containing protein CPP3" /calculated_mol_wt="5835" CDS 1..51 /gene="CPP3" /locus_tag="YDR034W-B" /coded_by="NM_001184327.3:1..156" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:37239347]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:38159851]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:37239347|PMID:26928762]" /note="Tail-anchored plasma membrane (PM) protein; C-terminal palmitoylation is required for membrane anchoring and protein stability; PM localization is polarized to the daughter cell; also localizes to the vacuolar membrane; may be involved in response to stress; upregulated by toxic concentrations of heavy metal ions and alkali; contains a conserved cysteine rich palmitoylated domain (CYSPD, aka CYSTM); CPP3 has a paralog, MNC1, that arose from the whole genome duplication" /db_xref="GeneID:851604" /db_xref="SGD:S000007234" ORIGIN 1 mrhhqnmhya pqqqpvyvqq ppprresggc crtcchflcc lclinlccdv f // LOCUS NP_010320 370 aa linear PLN 30-JUN-2025 DEFINITION 3-deoxy-7-phosphoheptulonate synthase ARO3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010320 VERSION NP_010320.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180343.3 REFERENCE 1 (residues 1 to 370) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 370) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 370) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 370) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11883. On Jul 30, 2012 this sequence version replaced NP_010320.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..370 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..370 /product="3-deoxy-7-phosphoheptulonate synthase ARO3" /EC_number="2.5.1.54" /calculated_mol_wt="40939" Region 15..365 /region_name="aroFGH" /note="phospho-2-dehydro-3-deoxyheptonate aldolase; TIGR00034" /db_xref="CDD:129145" CDS 1..370 /gene="ARO3" /locus_tag="YDR035W" /coded_by="NM_001180343.3:1..1113" /experiment="EXISTENCE:direct assay:GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity [PMID:2880280]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan" /db_xref="GeneID:851605" /db_xref="SGD:S000002442" ORIGIN 1 mfikndhagd rkrledwrik gydpltppdl lqhefpisak geeniikard svcdilngkd 61 drlvivigpc slhdpkaayd yadrlakise klskdlliim raylekprtt vgwkglindp 121 dmnnsfqink glrisremfi klveklpiag emldtispqf lsdcfslgai garttesqlh 181 relasglsfp igfkngtdgg lqvaidamra aahehyflsv tkpgvtaivg tegnkdtfli 241 lrggkngtnf dkesvqntkk qlekagltdd sqkrimidcs hgnsnkdfkn qpkvakciyd 301 qltegenslc gvmiesnine grqdipkegg reglkygcsv tdacigwest eqvlellaeg 361 vrnrrkalkk // LOCUS NP_010321 500 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS47 EHD3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010321 VERSION NP_010321.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180344.1 REFERENCE 1 (residues 1 to 500) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 500) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 500) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 500) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11884. Method: conceptual translation. FEATURES Location/Qualifiers source 1..500 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..500 /product="mitochondrial 37S ribosomal protein mS47 EHD3" /EC_number="3.1.2.4" /calculated_mol_wt="56158" Region 47..386 /region_name="ECH_2" /note="Enoyl-CoA hydratase/isomerase; pfam16113" /db_xref="CDD:465024" CDS 1..500 /gene="EHD3" /locus_tag="YDR036C" /gene_synonym="mS47" /coded_by="NM_001180344.1:1..1503" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity [PMID:12697341]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:17054397|P MID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]" /note="3-hydroxyisobutyryl-CoA hydrolase; member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis" /db_xref="GeneID:851606" /db_xref="SGD:S000002443" ORIGIN 1 mlrntlkcaq lsskygfktt trtfmttqpq lnvtdappvl ftvqdtarvi tlnrpkklna 61 lnaemsesmf ktlneyaksd ttnlvilkss nrprsfcagg dvatvaifnf nkefaksikf 121 ftdeyslnfq iatylkpivt fmdgitmggg vglsihtpfr iatentkwam pemdigffpd 181 vgstfalpri vtlansnsqm alylcltgev vtgadaymlg lashyvssen ldalqkrlge 241 isppfnndpq sayffgmvne sidefvsplp kdyvfkysne klnvieacfn lskngtiedi 301 mnnlrqyegs aegkafaqei ktklltksps slqialrlvq ensrdhiesa ikrdlytaan 361 mcmnqdslve fseatkhkli dkqrvpypwt kkeqlfvsql tsitspkpsl pmsllrntsn 421 vtwtqypyhs kyqlpteqei aayiekrtnd dtgakvtere vlnhfanvip srrgklgiqs 481 lckivcerkc eevndglrwk // LOCUS NP_010322 591 aa linear PLN 30-JUN-2025 DEFINITION lysine--tRNA ligase KRS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010322 VERSION NP_010322.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180345.1 REFERENCE 1 (residues 1 to 591) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 591) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 591) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 591) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11885. Method: conceptual translation. FEATURES Location/Qualifiers source 1..591 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..591 /product="lysine--tRNA ligase KRS1" /EC_number="6.1.1.6" /calculated_mol_wt="67828" Region 24..579 /region_name="PLN02502" /note="lysyl-tRNA synthetase" /db_xref="CDD:215278" Site 272..276 /site_type="other" /note="motif 1" /db_xref="CDD:238398" Site order(304,326,328,334,338,490,497,500,504,556) /site_type="active" /db_xref="CDD:238398" Site 325..328 /site_type="other" /note="motif 2" /db_xref="CDD:238398" Site 553..556 /site_type="other" /note="motif 3" /db_xref="CDD:238398" CDS 1..591 /gene="KRS1" /locus_tag="YDR037W" /gene_synonym="GCD5" /coded_by="NM_001180345.1:1..1776" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004824 lysine-tRNA ligase activity [PMID:3888626]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:330225]" /experiment="EXISTENCE:direct assay:GO:0006430 lysyl-tRNA aminoacylation [PMID:3888626]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:mutant phenotype:GO:0004824 lysine-tRNA ligase activity [PMID:7628447]" /experiment="EXISTENCE:mutant phenotype:GO:0006430 lysyl-tRNA aminoacylation [PMID:7628447]" /note="Lysyl-tRNA synthetase" /db_xref="GeneID:851607" /db_xref="SGD:S000002444" ORIGIN 1 msqqdnvkaa aegvanlhld eatgemvsks elkkrikqrq veakkaakka aaqpkpaskk 61 ktdlfadldp sqyfetrsrq iqelrkthep npyphkfhvs isnpeflaky ahlkkgetlp 121 eekvsiagri hakresgskl kfyvlhgdgv evqlmsqlqd ycdpdsyekd hdllkrgdiv 181 gvegyvgrtq pkkggegevs vfvsrvqllt pclhmlpadh fgfkdqetry rkryldlimn 241 kdarnrfitr seiiryirrf ldqrkfieve tpmmnviagg atakpfithh ndldmdmymr 301 iapelflkql vvggldrvye igrqfrnegi dmthnpeftt cefyqayadv ydlmdmtelm 361 fsemvkeitg syiikyhpdp adpakeleln fsrpwkrinm ieelekvfnv kfpsgdqlht 421 aetgeflkki lvdnklecpp pltnarmldk lvgeledtci nptfifghpq mmsplakysr 481 dqpglcerfe vfvatkeicn aytelndpfd qrarfeeqar qkdqgddeaq lvdetfcnal 541 eyglpptggw gcgidrlamf ltdsntirev llfptlkpdv lreevkkeee n // LOCUS NP_010323 1091 aa linear PLN 30-JUN-2025 DEFINITION putative Na(+)-exporting P-type ATPase ENA5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010323 VERSION NP_010323.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180346.3 REFERENCE 1 (residues 1 to 1091) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1091) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1091) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1091) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11886. On Jul 30, 2012 this sequence version replaced NP_010323.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1091 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1091 /product="putative Na(+)-exporting P-type ATPase ENA5" /EC_number="7.2.2.3" /calculated_mol_wt="120166" Region 11..1055 /region_name="ATPase-IID_K-Na" /note="potassium and/or sodium efflux P-type ATPase, fungal-type; TIGR01523" /db_xref="CDD:130586" CDS 1..1091 /gene="ENA5" /locus_tag="YDR038C" /coded_by="NM_001180346.3:1..3276" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Protein with similarity to P-type ATPase sodium pumps; member of the Na+ efflux ATPase family" /db_xref="GeneID:851608" /db_xref="SGD:S000002445" ORIGIN 1 msegtvkenn neefnayhtl tteeaaefig tsltegltqd eslrrlkavg entlgddtki 61 dykamvlhqv cnamimvlvi smaisfavrd witggvisfv iavnvliglv qeykatktmn 121 slknlsspna hvirngkset inskdvvpgd iclvkvgdti padlrlietk nfdtdesllt 181 geslpvskda nlvfgkeeet svgdrlnlaf sssavvkgra kgiviktaln seigkiaksl 241 qgdsglisrd pskswlqntw istkkvtgaf lgtnvgtplh rklsklavll fwiavlfaii 301 vmasqkfdvd krvaiyaicv alsmipsslv vvltitmsvg aavmvsrnvi vrkldsleal 361 gavndicsdk tgtltqgkml arqiwiprfg titisnsddp fnpnegnvsl iprfspyeys 421 hnedgdvgil qnfkdrlyek dlpedidmdl fqkwletatl aniatvfkdd atdcwkahgd 481 pteiaiqvfa tkmdlphnal tgekstnqsn endqsslsqh nekpgsaqfe hiaefpfdst 541 vkrmssvyyn nhnetyniyg kgafesiisc csswygkdgv kitpltdcdv etirknvysl 601 sneglrvlgf asksftkdqv nddqlknits nrataesdlv flgligiydp prnetagavk 661 kfhqaginvh mltgdfvgta kaiaqevgil ptnlyhysqe ivdsmvmtgs qfdglseeev 721 ddlpvlplvi arcspqtkvr miealhrrkk fcamtgdgvn dspslkmanv giamgingsd 781 vskeasdivl sddnfasiln aveegrrmtd niqkfvlqll aenvaqalyl iiglvfrden 841 gksvfplspv evlwiivvts cfpamglgle kaapdlmdrp pndsevgift weviidtfay 901 giimtgscma sftgslygin sgrlghdcdg tynsscrdvy rsrsaafatm twcalilawe 961 vvdmrrsffr mhpdtdspvk effrsiwgnq flfwsiifgf vsafpvvyip vindkvflhk 1021 pigaewglai aftiafwiga elykcgkrry fktqrahnse ndlersskhd pfeayststt 1081 lqseinisvk h // LOCUS NP_010324 1091 aa linear PLN 30-JUN-2025 DEFINITION Na(+)-exporting P-type ATPase ENA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010324 VERSION NP_010324.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180347.3 REFERENCE 1 (residues 1 to 1091) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1091) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1091) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1091) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11887. On Jul 30, 2012 this sequence version replaced NP_010324.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1091 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1091 /product="Na(+)-exporting P-type ATPase ENA2" /EC_number="7.2.2.3" /calculated_mol_wt="120187" Region 11..1055 /region_name="ATPase-IID_K-Na" /note="potassium and/or sodium efflux P-type ATPase, fungal-type; TIGR01523" /db_xref="CDD:130586" CDS 1..1091 /gene="ENA2" /locus_tag="YDR039C" /coded_by="NM_001180347.3:1..3276" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:7664728]" /experiment="EXISTENCE:genetic interaction:GO:0006814 sodium ion transport [PMID:1657642|PMID:10073572]" /experiment="EXISTENCE:genetic interaction:GO:0008554 P-type sodium transporter activity [PMID:1657642]" /experiment="EXISTENCE:genetic interaction:GO:0015662 P-type ion transporter activity [PMID:1657642]" /experiment="EXISTENCE:mutant phenotype:GO:0006813 potassium ion transport [PMID:11932440]" /experiment="EXISTENCE:mutant phenotype:GO:0008556 P-type potassium transmembrane transporter activity [PMID:11932440]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:11932440]" /note="P-type ATPase sodium pump; involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux" /db_xref="GeneID:851609" /db_xref="SGD:S000002446" ORIGIN 1 msegtvkenn neefnayhtl tteeaaefig tsltegltqd eslrrlkavg entlgddtki 61 dykamvlhqv cnamimvlvi smaisfavrd witggvisfv iavnvliglv qeykatktmn 121 slknlsspna hvirngkset inskdvvpgd iclvkvgdti padlrlietk nfdtdesllt 181 geslpvskda nlvfgkeeet svgdrlnlaf sssavvkgra kgiviktaln seigkiaksl 241 qgdsglisrd pskswlqntw istkkvtgaf lgtnvgtplh rklsklavll fwiavlfaii 301 vmasqkfdvd krvaiyaicv alsmipsslv vvltitmsvg aavmvsrnvi vrkldsleal 361 gavndicsdk tgtltqgkml arqiwiprfg titisnsddp fnpnegnvsl iprfspyeys 421 hnedgdvgil qnfkdrlyek dlpedidmdl fqkwletatl aniatvfkdd atdcwkahgd 481 pteiaiqvfa tkmdlphnal tgekstnqsn endqsslsqh nekpgsaqfe hiaefpfdst 541 vkrmssvyyn nhnetyniyg kgafesiisc csswygkdgv kitpltdcdv etirknvysl 601 sneglrvlgf asksftkdqv nddqlknits nrataesdlv flgligiydp prnetagavk 661 kfhqaginvh mltgdfvgta kaiaqevgil ptnlyhysqe ivdsmvmtgs qfdglseeev 721 ddlpvlplvi arcspqtkvr miealhrrkk fcamtgdgvn dspslkmanv giamgingsd 781 vskeasdivl sddnfasiln aveegrrmtd niqkfvlqll aenvaqalyl iiglvfrden 841 gksvfplspv evlwiivvts cfpamglgle kaapdlmdrp phdsevgift weviidtfay 901 giimtgscma sftgslygin sgrlghdcdg tynsscrdvy rsrsaafatm twcalilawe 961 vvdmrrsffr mhpdtdspvk effrsiwgnq flfwsiifgf vsafpvvyip vindkvflhk 1021 pigaewglai aftiafwiga elykcgkrry fktqrahnpe ndlesnnkrd pfeayststt 1081 ihtevnigik q // LOCUS NP_010325 1091 aa linear PLN 30-JUN-2025 DEFINITION Na(+)/Li(+)-exporting P-type ATPase ENA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010325 VERSION NP_010325.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180348.1 REFERENCE 1 (residues 1 to 1091) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1091) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1091) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1091) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11888. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1091 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1091 /product="Na(+)/Li(+)-exporting P-type ATPase ENA1" /EC_number="7.2.2.3" /calculated_mol_wt="120227" Region 11..1055 /region_name="ATPase-IID_K-Na" /note="potassium and/or sodium efflux P-type ATPase, fungal-type; TIGR01523" /db_xref="CDD:130586" CDS 1..1091 /gene="ENA1" /locus_tag="YDR040C" /gene_synonym="HOR6; PMR2" /coded_by="NM_001180348.1:1..3276" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:7664728|PMID:9315618]" /experiment="EXISTENCE:direct assay:GO:0008554 P-type sodium transporter activity [PMID:9315618]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:9315618]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006814 sodium ion transport [PMID:1657642]" /experiment="EXISTENCE:genetic interaction:GO:0006972 hyperosmotic response [PMID:8612770]" /experiment="EXISTENCE:genetic interaction:GO:0008554 P-type sodium transporter activity [PMID:1657642]" /experiment="EXISTENCE:genetic interaction:GO:0009268 response to pH [PMID:12453218]" /experiment="EXISTENCE:genetic interaction:GO:0009651 response to salt stress [PMID:11457832]" /experiment="EXISTENCE:mutant phenotype:GO:0006813 potassium ion transport [PMID:11932440]" /experiment="EXISTENCE:mutant phenotype:GO:0008556 P-type potassium transmembrane transporter activity [PMID:11932440]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:9383192]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:9315618]" /note="P-type ATPase sodium pump; involved in Na+ and Li+ efflux to allow salt tolerance; mutated in the Sigma1278b background resulting in NaCl sensitivity, resulting from a lack of an active Na+ ATPase exporter" /db_xref="GeneID:851610" /db_xref="SGD:S000002447" ORIGIN 1 mgegttkenn naefnayhtl taeeaaefig tsltegltqd efvhrlktvg entlgddtki 61 dykamvlhqv cnamimvlli smiisfamhd witggvisfv iavnvliglv qeykatktmn 121 slknlsspna hvirngkset inskdvvpgd iclvkvgdti padlrlietk nfdtdesllt 181 geslpvskda nlvfgkeeet svgdrlnlaf sssavvkgra kgiviktaln seigkiaksl 241 qgdsglisrd pskswlqntw istkkvtgaf lgtnvgtplh rklsklavll fwiavlfaii 301 vmasqkfdvd krvaiyaicv alsmipsslv vvltitmsvg aavmvsrnvi vrkldsleal 361 gavndicsdk tgtltqgkml arqiwiprfg titisnsddp fnpnegnvsl iprfspyeys 421 hnedgdvgil qnfkdrlyek dlpedidmdl fqkwletatl aniatvfkdd atdcwkahgd 481 pteiaiqvfa tkmdlphnal tgekstnqsn endqsslsqh nekpgsaqfe hiaefpfdst 541 vkrmssvyyn nhnetyniyg kgafesiisc csswygkdgv kitpltdcdv etirknvysl 601 sneglrvlgf asksftkdqv nddqlknits nrataesdlv flgligiydp prnetagavk 661 kfhqaginvh mltgdfvgta kaiaqevgil ptnlyhysqe ivdsmvmtgs qfdglseeev 721 ddlpvlplvi arcspqtkvr miealhrrkk fctmtgdgvn dspslkmanv giamgingsd 781 vskeasdivl sddnfasiln aveegrrmtd niqkfvlqll aenvaqalyl iiglvfrden 841 gksvfplspv evlwiivvts cfpamglgle kaapdlmdrp phdsevgift weviidtfay 901 giimtgscma sftgslygin sgrlghdcdg tynsscrdvy rsrsaafatm twcalilawe 961 vvdmrrsffr mhpdtdspvk effrsiwgnq flfwsiifgf vsafpvvyip vindkvflhk 1021 pigaewglai aftiafwiga elykcgkrry fktqrahnpe ndlesnnkrd pfeayststt 1081 ihtevnigik q // LOCUS NP_010326 203 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS10m RSM10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010326 VERSION NP_010326.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180349.1 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11889. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..203 /product="mitochondrial 37S ribosomal protein uS10m RSM10" /calculated_mol_wt="23293" Region 45..141 /region_name="Ribosomal_S10" /note="Ribosomal protein S10p/S20e; pfam00338" /db_xref="CDD:459769" CDS 1..203 /gene="RSM10" /locus_tag="YDR041W" /gene_synonym="uS10m" /coded_by="NM_001180349.1:1..612" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins" /db_xref="GeneID:851611" /db_xref="SGD:S000002448" ORIGIN 1 mlrntialrs firtqstrpy pvnveavyya plklpikygd lvadiqlrsy dnenldfysd 61 filrtgyylg ipltgpkplp trrerwtvik spfvhakske nferhthkrl irawdtnpev 121 lqmliayitk hsmagvgmkc nffqrseisl dlgsdangle kslsnidely slrnddkaqt 181 savgqkvlel ldspdfkkhl ekk // LOCUS NP_010327 200 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR042C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010327 VERSION NP_010327.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180350.3 REFERENCE 1 (residues 1 to 200) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 200) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 200) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 200) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11890. On Jul 30, 2012 this sequence version replaced NP_010327.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..200 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..200 /product="uncharacterized protein" /calculated_mol_wt="23118" CDS 1..200 /locus_tag="YDR042C" /coded_by="NM_001180350.3:1..603" /note="hypothetical protein; expression is increased in ssu72-ts69 mutant" /db_xref="GeneID:851612" /db_xref="SGD:S000002449" ORIGIN 1 meqilynqsl kistlstfqg lkflkvlifs ifqqlfynpv iqlfgtkasi mesdsttlle 61 sswsternfl nmnsdsisat knvfilffti frlaeyivyk lsdqkyrlht slnvqhfrwn 121 skkntnrkrt lsfskaylpr tnilpifvad glknrfsgpl pgkslesfqk lnllsdnnik 181 ryavpgnkav ntllwqeqys // LOCUS NP_010328 231 aa linear PLN 30-JUN-2025 DEFINITION transcriptional regulator NRG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010328 VERSION NP_010328.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180351.3 REFERENCE 1 (residues 1 to 231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 231) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11891. On Jul 30, 2012 this sequence version replaced NP_010328.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..231 /product="transcriptional regulator NRG1" /calculated_mol_wt="26612" Region <21..>229 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 176..196 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 204..226 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..231 /gene="NRG1" /locus_tag="YDR043C" /coded_by="NM_001180351.3:1..696" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:17023428|PMID:10022891]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10022891]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11404322]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15466424|PMID:12024013|PMID:16278455]" /experiment="EXISTENCE:genetic interaction:GO:0043709 cell adhesion involved in single-species biofilm formation [PMID:12024013]" /experiment="EXISTENCE:genetic interaction:GO:2000218 negative regulation of invasive growth in response to glucose limitation [PMID:15466424|PMID:12024013]" /experiment="EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:12024013]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12509465|PMID:17023428|PMID:18287536]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10022891]" /experiment="EXISTENCE:mutant phenotype:GO:0090606 single-species surface biofilm formation [PMID:16556982]" /experiment="EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12509465]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:10022891]" /note="Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; activated in stochastic pulses of nuclear localization in response to low glucose" /db_xref="GeneID:851613" /db_xref="SGD:S000002450" ORIGIN 1 mfypynysnl nvstmpalpg isafdgmqde enveisperk yqtllpvltn shvvenelkh 61 klnktafdfr yqtksengse kwepkylitp nlqtrsvsfd nssvqynsds seksslsqlt 121 cnssiiqqpe ngivsndayn kmansryslk trkqrtdprn tlsdeedleq rrkyickica 181 rgfttsghla rhnrihtgek nhccpykgct qrfsrhdncl qhyrthlkkg q // LOCUS NP_010329 328 aa linear PLN 30-JUN-2025 DEFINITION coproporphyrinogen oxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010329 VERSION NP_010329.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180352.1 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11892. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..328 /product="coproporphyrinogen oxidase" /EC_number="1.3.3.3" /calculated_mol_wt="37581" Region 15..326 /region_name="Coprogen_oxidas" /note="Coproporphyrinogen III oxidase; pfam01218" /db_xref="CDD:460116" CDS 1..328 /gene="HEM13" /locus_tag="YDR044W" /coded_by="NM_001180352.1:1..987" /experiment="EXISTENCE:direct assay:GO:0004109 coproporphyrinogen oxidase activity [PMID:3516695]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:3516695]" /experiment="EXISTENCE:mutant phenotype:GO:0004109 coproporphyrinogen oxidase activity [PMID:2838478]" /experiment="EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:7035824]" /note="Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); human homolog CPOX can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid" /db_xref="GeneID:851614" /db_xref="SGD:S000002451" ORIGIN 1 mpapqdprnl pirqqmeali rrkqaeitqg lesidtvkfh adtwtrgndg gggtsmviqd 61 gttfekggvn vsvvygqlsp aavsamkadh knlrlpedpk tglpvtdgvk ffacglsmvi 121 hpvnphaptt hlnyryfetw nqdgtpqtww fgggadltps ylyeedgqlf hqlhkdaldk 181 hdtalyprfk kwcdeyfyit hrketrgigg iffddyderd pqeilkmved cfdaflpsyl 241 tivkrrkdmp ytkeeqqwqa irrgryvefn liydrgtqfg lrtpgsrves ilmslpehas 301 wlynhhpapg sreakllevt tkprewvk // LOCUS NP_010330 110 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase III core subunit RPC11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010330 VERSION NP_010330.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180353.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11893. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..110 /product="DNA-directed RNA polymerase III core subunit RPC11" /calculated_mol_wt="12382" Region 4..109 /region_name="RPB9" /note="DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]; COG1594" /db_xref="CDD:441202" Region 61..109 /region_name="Zn-ribbon_RPC11" /note="C-terminal zinc ribbon domain of RPC11 subunit of RNA polymerase III; cd10509" /db_xref="CDD:259794" Site order(69,75,100,103) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:259794" CDS 1..110 /gene="RPC11" /locus_tag="YDR045C" /coded_by="NM_001180353.1:1..333" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:9869639|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793|PMID:9869639]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0003899 DNA-directed RNA polymerase activity [PMID:9869639]" /experiment="EXISTENCE:mutant phenotype:GO:0006386 termination of RNA polymerase III transcription [PMID:9869639]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:9869639]" /note="RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS" /db_xref="GeneID:851615" /db_xref="SGD:S000002452" ORIGIN 1 mlsfcpscnn mllitsgdsg vytlacrscp yefpiegiei ydrkklprke vddvlgggwd 61 nvdqtktqcp nydtcggesa yffqlqirsa depmttfykc vncghrwken // LOCUS NP_010331 604 aa linear PLN 30-JUN-2025 DEFINITION amino acid transporter BAP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010331 VERSION NP_010331.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180354.3 REFERENCE 1 (residues 1 to 604) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 604) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 604) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 604) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11894. On Jul 30, 2012 this sequence version replaced NP_010331.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..604 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..604 /product="amino acid transporter BAP3" /calculated_mol_wt="67234" Region 87..568 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..604 /gene="BAP3" /locus_tag="YDR046C" /gene_synonym="PAP1" /coded_by="NM_001180354.3:1..1815" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006865 amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015171 amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:10654085]" /note="Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication" /db_xref="GeneID:851616" /db_xref="SGD:S000002453" ORIGIN 1 msdpivtssk meksaefevt dsalynnfnt sttasltpei kehseesrng lvhrfvdsfr 61 raesqrleed ndledgtksm ksnnhlkksm ksrhvvmmsl gtgigtgllv anakglslag 121 pgslvigyvm vsfvtyfmvq aagemgvtyp tlpgnfnayn sifisksfgf attwlfciqw 181 ltvlplelit ssmtvkywnd tinadvfivi fyvfllfihf fgvkaygete fifnsckilm 241 vagfiilsvv incggagvdg yiggkywrdp gsfaegsgat rfkgicyilv sayfsfggie 301 lfvlsineqs nprkstpvaa krsvyrilii ylltmiligf nvphnndqlm gsggsathas 361 pyvlaasihk vrviphiina vilisvisva nsalyaaprl mcslaqqgya pkflnyidre 421 grplralvvc slvgvvgfva cspqeeqaft wlaaiaglse lftwsgimls hirfrkamkv 481 qgrsldevgy kantgiwgsy ygvffnmlvf maqfwvalsp ignggkcdaq affesylaap 541 lwifmyvgym vykrdftfln pldkidldfh rrvydpeimr qedeenkerl knssifvrvy 601 kfwc // LOCUS NP_010332 362 aa linear PLN 30-JUN-2025 DEFINITION uroporphyrinogen decarboxylase HEM12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010332 VERSION NP_010332.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180355.3 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11895. On Jul 30, 2012 this sequence version replaced NP_010332.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..362 /product="uroporphyrinogen decarboxylase HEM12" /EC_number="4.1.1.37" /calculated_mol_wt="41218" Region 13..358 /region_name="URO-D" /note="Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; cd00717" /db_xref="CDD:238368" Site order(29..34,39,43,48,77..83,95,100,150,160,166,213, 215..216,258,338) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238368" Site order(30,34,81,160,215,338) /site_type="active" /db_xref="CDD:238368" CDS 1..362 /gene="HEM12" /locus_tag="YDR047W" /gene_synonym="HEM6" /coded_by="NM_001180355.3:1..1089" /experiment="EXISTENCE:direct assay:GO:0004853 uroporphyrinogen decarboxylase activity [PMID:2180703]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:2180703]" /experiment="EXISTENCE:mutant phenotype:GO:0004853 uroporphyrinogen decarboxylase activity [PMID:7035824]" /experiment="EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:14559249|PMID:1471989|PMID:7035824]" /note="Uroporphyrinogen decarboxylase; catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda" /db_xref="GeneID:851617" /db_xref="SGD:S000002454" ORIGIN 1 mgnfpapknd lilraakgek verppcwimr qagrylpeyh evknnrdffq tcrdaeiase 61 itiqpvrryr glidaaiifs dilvipqamg mrvemlegkg phfpeplrnp edlqtvldyk 121 vdvlkeldwa fkaitmtrik ldgevplfgf cggpwtlmvy mtegggsrlf rfakqwinmy 181 pelshkllqk itdvavefls qqvvagaqil qvfeswggel ssvdfdefsl pylrqiaerv 241 pkrlqelgim eqipmivfak gswyaldklc csgfdvvsld wswdpreavk inknrvtlqg 301 nldpgvmygs kevitkkvkq mieafgggks ryivnfghgt hpfmdpdvik ffleechrig 361 sk // LOCUS NP_010334 632 aa linear PLN 30-JUN-2025 DEFINITION Vms1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010334 VERSION NP_010334.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180357.1 REFERENCE 1 (residues 1 to 632) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 632) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 632) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 632) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11896. Method: conceptual translation. FEATURES Location/Qualifiers source 1..632 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..632 /product="Vms1p" /calculated_mol_wt="72603" Region <22..115 /region_name="PTZ00448" /note="hypothetical protein; Provisional" /db_xref="CDD:185627" Region 74..96 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275371" Region 237..397 /region_name="bVLRF1" /note="Bacteroidetes VLRF1 release factor; pfam18826" /db_xref="CDD:465880" CDS 1..632 /gene="VMS1" /locus_tag="YDR049W" /coded_by="NM_001180357.1:1..1899" /experiment="EXISTENCE:direct assay:GO:0004045 peptidyl-tRNA hydrolase activity [PMID:29632312]" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:31189955]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:21070972]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:21148305]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:21070972]" /experiment="EXISTENCE:direct assay:GO:0036266 Cdc48p-Npl4p-Vms1p AAA ATPase complex [PMID:21070972]" /experiment="EXISTENCE:direct assay:GO:0072344 rescue of stalled ribosome [PMID:31189955]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:21148305]" /experiment="EXISTENCE:mutant phenotype:GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system [PMID:22718752]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:21070972]" /note="Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, component of a Cdc48p-complex; involved in protein quality control; exhibits cytosolic and ER-membrane localization; contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; translocates to mitochondria under oxidative stress and forms a complex with Cdc48p and Npl4p that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD)" /db_xref="GeneID:851618" /db_xref="SGD:S000002456" ORIGIN 1 mnsqkaskmt gslkkndlyi fdlseqllns lklmsfdstl revevektsd ndrnkesgdl 61 qiarkkvtsn vmrcsvcqms fdsrneqkah yqtdyhlmnv krnlrgldil sveefdalis 121 kehgiksede nsggeqtssd heeseeasdr dpdlqtnnym etiiendlqk lgfqkdesda 181 ishintqspy iyfkskylqk nevlaiyksl fnkrslsnpn ealtfwnsqe npmaisalfm 241 vggghfagai vshqrlnvkg nahkkdetli eqavnflehk tfhryttrrk qggsqsamdn 301 akgkansags alrrynesal ktdiqgvlkd wepylskcdn ifirarnvsd kkiftdntvl 361 nkgderiksf pfttnrptvl elkkawcels ylkilpkpep lavketvqkl evsnkkdefk 421 ekqeplleei qteeiisllk kgrapllisf lkknkldgnf rlkpeskysl tptmlhyasq 481 qgmkqmalil lsnikcdpti knrlgrtawd lnrnddvrha fqiarynlge sftnwdethi 541 gqplsreqvd einekkkaie nekaeklikl eleaakekqr fakdaergpg kkltnipsiq 601 qqnlnsltde qrrrlmreqr araaeermkk ky // LOCUS NP_010335 248 aa linear PLN 30-JUN-2025 DEFINITION triose-phosphate isomerase TPI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010335 VERSION NP_010335.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180358.1 REFERENCE 1 (residues 1 to 248) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 248) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 248) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 248) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11897. Method: conceptual translation. FEATURES Location/Qualifiers source 1..248 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..248 /product="triose-phosphate isomerase TPI1" /EC_number="5.3.1.1" /calculated_mol_wt="26664" Region 5..245 /region_name="TIM" /note="Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; cd00311" /db_xref="CDD:238190" Site order(10,12,95,165,171,211,230,232..233) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238190" Site order(10,13,44..46,48,51,64,82,85..86,97..98) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238190" Site order(12,95,165) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:238190" CDS 1..248 /gene="TPI1" /locus_tag="YDR050C" /coded_by="NM_001180358.1:1..747" /experiment="EXISTENCE:direct assay:GO:0004807 triose-phosphate isomerase activity [PMID:236471]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:27385335]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:11329176]" /note="Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human homolog TPI1 causes a rare autosomal disease; human TPI1 can complement yeast null mutant" /db_xref="GeneID:851620" /db_xref="SGD:S000002457" ORIGIN 1 martffvggn fklngskqsi keiverlnta sipenvevvi cppatyldys vslvkkpqvt 61 vgaqnaylka sgaftgensv dqikdvgakw vilghserrs yfheddkfia dktkfalgqg 121 vgvilciget leekkagktl dvverqlnav leevkdwtnv vvayepvwai gtglaatped 181 aqdihasirk flasklgdka aselrilygg sangsnavtf kdkadvdgfl vggaslkpef 241 vdiinsrn // LOCUS NP_010336 334 aa linear PLN 30-JUN-2025 DEFINITION acid phosphatase DET1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010336 VERSION NP_010336.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180359.3 REFERENCE 1 (residues 1 to 334) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 334) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 334) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 334) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11898. On Jul 30, 2012 this sequence version replaced NP_010336.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..334 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..334 /product="acid phosphatase DET1" /calculated_mol_wt="39041" Region 27..321 /region_name="PhoE" /note="Broad specificity phosphatase PhoE [Carbohydrate transport and metabolism]; COG0406" /db_xref="CDD:440175" CDS 1..334 /gene="DET1" /locus_tag="YDR051C" /coded_by="NM_001180359.3:1..1005" /experiment="EXISTENCE:direct assay:GO:0003993 acid phosphatase activity [PMID:19753119]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0032366 intracellular sterol transport [PMID:19060182]" /note="Acid phosphatase; involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel" /db_xref="GeneID:851621" /db_xref="SGD:S000002458" ORIGIN 1 mceenvhvse dvagshgsft narprlivli rhgesesnkn kevngyipnh lisltktgqi 61 qarqagidll rvlnvddhnl vedlakkyik dessrrtlpl kdytrlsrek dtnivfytsp 121 yrraretlkg ildvideyne lnsgvriced mrydphgkqk hafwprglnn tggvyenned 181 nicegkpgkc ylqyrvkdep rireqdfgnf qkinsmqdvm kkrstyghff frfphgesaa 241 dvydrvasfq etlfrhfhdr qerrprdvvv lvthgiysrv flmkwfrwty eefesftnvp 301 ngsvmvmeld esinryvlrt vlpkwtdceg dltt // LOCUS NP_010337 704 aa linear PLN 30-JUN-2025 DEFINITION protein serine/threonine kinase activating protein DBF4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010337 VERSION NP_010337.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180360.3 REFERENCE 1 (residues 1 to 704) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 704) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 704) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 704) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11899. On Jul 30, 2012 this sequence version replaced NP_010337.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..704 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..704 /product="protein serine/threonine kinase activating protein DBF4" /calculated_mol_wt="80559" Region 1..704 /region_name="DBF4" /note="Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]; COG5067" /db_xref="CDD:227399" CDS 1..704 /gene="DBF4" /locus_tag="YDR052C" /gene_synonym="DNA52; LSD7" /coded_by="NM_001180360.3:1..2115" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23746350]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10508166]" /experiment="EXISTENCE:direct assay:GO:0001934 positive regulation of protein phosphorylation [PMID:19692334]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:8066465]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0031431 Dbf4-dependent protein kinase complex [PMID:19692334]" /experiment="EXISTENCE:genetic interaction:GO:0001100 negative regulation of exit from mitosis [PMID:19478884]" /experiment="EXISTENCE:genetic interaction:GO:0001934 positive regulation of protein phosphorylation [PMID:8474449]" /experiment="EXISTENCE:genetic interaction:GO:0031431 Dbf4-dependent protein kinase complex [PMID:8474449]" /experiment="EXISTENCE:genetic interaction:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:18372119]" /experiment="EXISTENCE:genetic interaction:GO:0043539 protein serine/threonine kinase activator activity [PMID:8474449]" /experiment="EXISTENCE:genetic interaction:GO:1903468 positive regulation of DNA replication initiation [PMID:9407029]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:19478884]" /experiment="EXISTENCE:mutant phenotype:GO:0001934 positive regulation of protein phosphorylation [PMID:8474449]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:16319063]" /experiment="EXISTENCE:mutant phenotype:GO:0043539 protein serine/threonine kinase activator activity [PMID:8474449]" /experiment="EXISTENCE:mutant phenotype:GO:0060903 positive regulation of meiosis I [PMID:16319063]" /experiment="EXISTENCE:physical interaction:GO:0006270 DNA replication initiation [PMID:8474449]" /experiment="EXISTENCE:physical interaction:GO:0031431 Dbf4-dependent protein kinase complex [PMID:8474449]" /note="Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress; co-expression of human CDC7 and DBF4 complements single cdc7 or dbf4 null mutations or the cdc7 dbf4 double null mutation" /db_xref="GeneID:851623" /db_xref="SGD:S000002459" ORIGIN 1 mvsptkmiir splketdtnl khnngiaast taaghlnvfs ndnncnnnnt tesfpkkrsl 61 erlelqqqqh lhekkrarie rarsiegavq vskgtglknv eprvtpkell ewqtnwkkim 121 krdsriyfdi tddvemntyn kskmdkrrdl lkrgfltlga qitqffdttv tivitrrsve 181 niyllkdtdi lsrakknymk vwsyekaarf lknldvdldh lsktksasla aptlsnllhn 241 eklygptdrd prtkrddihy fkyphvylyd lwqtwapiit lewkpqeltn ldelpypilk 301 igsfgrcpfi gdrnydessy krvvkrysrd kankkyalql ralfqyhadt llntssvndq 361 tknlifipht cndstksfkk wmqekaknfe ktelkktdds avqdvrneha dqtdeknsil 421 lnetetkepp lkeekenkqs iaeesnkypq rkelaatpkl nhpvlatfar qeteevpddl 481 ctlktksrqa feikasgahq sndvatsfgn glgptrasvm sknmkslsrl mvdrklgvkq 541 tngnnknyta tiattaetsk enrhrldfna lkkdeapske tgkdsavhle tnrkpqnfpk 601 vatksvsads kvhndikitt tesptaskks tstnvtlhfn aqtaqtaqpv kketvknsgy 661 cencrvkyes leqhivsekh lsfaendlnf eaidslienl rfqi // LOCUS NP_010339 295 aa linear PLN 30-JUN-2025 DEFINITION SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010339 VERSION NP_010339.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180362.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11900. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..295 /product="SCF E2 ubiquitin-protein ligase catalytic subunit CDC34" /EC_number="2.3.2.23" /calculated_mol_wt="33934" Region 8..178 /region_name="UBCc_ScCDC34-like" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Saccharomyces cerevisiae CDC34 and related proteins; cd23811" /db_xref="CDD:467431" CDS 1..295 /gene="CDC34" /locus_tag="YDR054C" /gene_synonym="DNA6; UBC3" /coded_by="NM_001180362.1:1..888" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:1848239]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:9346239|PMID:2842867]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11080155|PMID:8164658]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9346239|PMID:9346238]" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:9346238]" /experiment="EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:9346238|PMID:9346239]" /experiment="EXISTENCE:direct assay:GO:0051865 protein autoubiquitination [PMID:8383676]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:9346238]" /experiment="EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:9736614|PMID:7954792]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:2842867]" /experiment="EXISTENCE:mutant phenotype:GO:0019005 SCF ubiquitin ligase complex [PMID:9736614]" /experiment="EXISTENCE:mutant phenotype:GO:0051865 protein autoubiquitination [PMID:8383676]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:9346238]" /note="Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress; human CDC34 functionally complements the thermosensitivity of the cdc34-2 mutant" /db_xref="GeneID:851624" /db_xref="SGD:S000002461" ORIGIN 1 mssrkstass lllrqyrelt dpkkaipsfh ieleddsnif twnigvmvln edsiyhggff 61 kaqmrfpedf pfsppqfrft paiyhpnvyr dgrlcisilh qsgdpmtdep daetwspvqt 121 vesvlisivs lledpninsp anvdaavdyr knpeqykqrv kmeverskqd ipkgfimpts 181 esayisqskl depesnkdma dnfwydsdld ddengsvilq dddyddgnnh ipfedddvyn 241 yndndddder iefedddddd ddsidndsvm drkqphkaed esedvedver vskki // LOCUS NP_010340 444 aa linear PLN 30-JUN-2025 DEFINITION Pst1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010340 VERSION NP_010340.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180363.1 REFERENCE 1 (residues 1 to 444) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 444) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 444) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 444) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11901. Method: conceptual translation. FEATURES Location/Qualifiers source 1..444 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..444 /product="Pst1p" /calculated_mol_wt="45646" CDS 1..444 /gene="PST1" /locus_tag="YDR055W" /gene_synonym="HPF2" /coded_by="NM_001180363.1:1..1335" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15583168]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953|PMID:15583168]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:15583168]" /note="Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1; PST1 has a paralog, ECM33, that arose from the whole genome duplication" /db_xref="GeneID:851625" /db_xref="SGD:S000002462" ORIGIN 1 mqlhsliast allitsalaa tsssssipss ctisshatat aqsdldkysr cdtlvgnlti 61 ggglktgala nvkeingslt ifnatnltsf aadslesitd slnlqsltil tsasfgslqs 121 vdsiklitlp aissftsnik sanniyisdt slqsvdgfsa lkkvnvfnvn nnkkltsiks 181 pvetvsdslq fsfngnqtki tfddlvwann isltdvhsvs fanlqkinss lgfinnsiss 241 lnftklntig qtfsivsndy lknlsfsnls tiggalvvan ntglqkiggl dnlttiggtl 301 evvgnftsln ldslksvkgg adveskssnf scnalkalqk kggikgesfv ckngasstsv 361 klsstsksqs sqttakvsks sskaeekkft sgdikaaasa ssvsssgass sssksskgna 421 aimapigqtt plvglltaii msim // LOCUS NP_010341 205 aa linear PLN 30-JUN-2025 DEFINITION Emc10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010341 VERSION NP_010341.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180364.3 REFERENCE 1 (residues 1 to 205) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 205) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 205) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 205) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11902. On Jul 30, 2012 this sequence version replaced NP_010341.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..205 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..205 /product="Emc10p" /calculated_mol_wt="22638" Region 21..129 /region_name="EMC10" /note="ER membrane protein complex subunit 10 and similar proteins; cd22209" /db_xref="CDD:412067" Site order(63,65,70,77..81,83,95,97..98,101..104,106,123..129) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:412067" CDS 1..205 /gene="EMC10" /locus_tag="YDR056C" /coded_by="NM_001180364.3:1..618" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /note="hypothetical protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5p of TOM (Translocase of the Mitochondrial Outer Membrane) complex; YDR056C is not an essential protein" /db_xref="GeneID:851626" /db_xref="SGD:S000002463" ORIGIN 1 mlvrllrvil lasmvfcadi lqlsysddak daiplgtfei dstsdgnvtv ttvniqdvev 61 sgeyclnaqi egkldmpcfs ymklrtplky dlivdvdedn evkqvslsyd etndaitatv 121 rypeagptap vtklkkktkt yadkkasknk dgstaqfeed eevkevswfq knwkmlllgl 181 liynfvagsa kkqqqggaga dqkte // LOCUS NP_010342 542 aa linear PLN 30-JUN-2025 DEFINITION Yos9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010342 VERSION NP_010342.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180365.3 REFERENCE 1 (residues 1 to 542) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 542) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 542) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 542) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11903. On Jul 30, 2012 this sequence version replaced NP_010342.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..542 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..542 /product="Yos9p" /calculated_mol_wt="61127" Region 116..193 /region_name="PRKCSH" /note="Glucosidase II beta subunit-like protein; pfam07915" /db_xref="CDD:400321" Region 271..395 /region_name="Yos9_DD" /note="Yos9 dimerzation domain; pfam17880" /db_xref="CDD:407735" Site order(349,351,366,368,370,376,378,380,392..396) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:213372" CDS 1..542 /gene="YOS9" /locus_tag="YDR057W" /coded_by="NM_001180365.3:1..1629" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:16168371]" /experiment="EXISTENCE:direct assay:GO:0034099 luminal surveillance complex [PMID:16873065]" /experiment="EXISTENCE:direct assay:GO:0070492 oligosaccharide binding [PMID:19111666]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:22298424]" /experiment="EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:24292014]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:16168370|PMID:16168371|PMID:22298424|PMID:16168372]" /experiment="EXISTENCE:mutant phenotype:GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway [PMID:19124653]" /experiment="EXISTENCE:physical interaction:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873066]" /note="ER quality-control lectin; integral subunit of the HRD ligase; participates in efficient ER retention of misfolded proteins by recognizing them and delivering them to Hrd1p; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family" /db_xref="GeneID:851627" /db_xref="SGD:S000002464" ORIGIN 1 mqakiiyals aisaliplgs sllapiedpi vsnkylisyi deddwsdril qnqsvmnsgy 61 ivnmgddlec fiqnastqln dvledsnehs nsektalltk tlnqgvktif dklnercify 121 qagfwiyeyc pgiefvqfhg rvntktgeiv nrdeslvyrl gkpkanveer efellyddvg 181 yyiseiigsg dicdvtgaer mveiqyvcgg snsgpstiqw vretkicvye aqvtipelcn 241 lellaknedq knaspilcrm pakskigsns idlitkyepi flgsgiyflr pfntderdkl 301 mvtdnamsnw deitetyyqk fgnainkmls lrlvslpngh ilqpgdscvw laevvdmkdr 361 fqttlslnil nsqraeiffn ktftfnedng nflsykigdh gestelgqit hsnkadinta 421 eirsdeylin tdnelflris keiaevkell neivspheme vifenmrnqp nndfelalmn 481 klksslnddn kveqinnarm dddestshtt rdigeagsqt tgntesevtn vaagvfiehd 541 el // LOCUS NP_010343 326 aa linear PLN 30-JUN-2025 DEFINITION triglyceride lipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010343 VERSION NP_010343.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180366.1 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11904. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..326 /product="triglyceride lipase" /EC_number="3.1.1.3" /calculated_mol_wt="37369" Region 21..175 /region_name="EstA" /note="Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism]; COG1075" /db_xref="CDD:440693" CDS 1..326 /gene="TGL2" /locus_tag="YDR058C" /coded_by="NM_001180366.1:1..981" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:19959834|PMID:9544243]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19959834]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:39863106]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:31483742]" /experiment="EXISTENCE:mutant phenotype:GO:0004806 triacylglycerol lipase activity [PMID:19959834|PMID:9544243]" /experiment="EXISTENCE:mutant phenotype:GO:0019433 triglyceride catabolic process [PMID:19959834]" /note="Triacylglycerol lipase involved in mitochondrial lipid homeostasis; contains lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli; localizes to the mitochondrial inner membrane; forms homodimers under non reducing conditions" /db_xref="GeneID:851628" /db_xref="SGD:S000002465" ORIGIN 1 mkndnkandi iidsvkvpds ykppknpivf chglsgfdkl ilipsvfhlt nlisnsivhn 61 maenfmqdde dksdnkytnl leieywigvk kflqskgctv ittkvpgfgs ieeramalda 121 qlqkevkkie skdkrhslnl iahsmggldc rylicniknr nydilsltti stphrgsema 181 dyvvdlfenl nalrvsqkil picfyqltta ymkyfnlvtp nspkvsyfsy gcsfvpkwyn 241 vfctpwkivy erskgcpndg lvtinsskwg eyrgtlkdmd hldvinwknk lqddwskffr 301 tttvgekvdi lnfylkitdd larkgf // LOCUS NP_010344 148 aa linear PLN 30-JUN-2025 DEFINITION E2 ubiquitin-conjugating protein UBC5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010344 VERSION NP_010344.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180367.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11905. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..148 /product="E2 ubiquitin-conjugating protein UBC5" /EC_number="2.3.2.23" /calculated_mol_wt="16149" Region 4..146 /region_name="UBCc_UBE2D" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzyme E2 D1-D3 and related proteins; cd23792" /db_xref="CDD:467412" CDS 1..148 /gene="UBC5" /locus_tag="YDR059C" /coded_by="NM_001180367.1:1..447" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:2154373]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:2154373]" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:10848595]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]" /note="Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible; protein abundance increases in response to DNA replication stress; UBC5 has a paralog, UBC4, that arose from the whole genome duplication" /db_xref="GeneID:851631" /db_xref="SGD:S000002466" ORIGIN 1 mssskriake lsdlgrdppa scsagpvgdd lyhwqasimg psdspyaggv fflsihfptd 61 ypfkppkvnf ttkiyhpnin ssgnicldil kdqwspaltl skvllsicsl ltdanpddpl 121 vpeiaqiykt dkakyeatak ewtkkyav // LOCUS NP_010345 1025 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding ribosome biosynthesis protein MAK21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010345 VERSION NP_010345.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180368.3 REFERENCE 1 (residues 1 to 1025) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1025) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1025) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1025) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11906. On Jul 30, 2012 this sequence version replaced NP_010345.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1025 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1025 /product="RNA-binding ribosome biosynthesis protein MAK21" /calculated_mol_wt="116546" Region 173..1022 /region_name="COG5593" /note="Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]" /db_xref="CDD:227880" CDS 1..1025 /gene="MAK21" /locus_tag="YDR060W" /gene_synonym="NOC1" /coded_by="NM_001180368.3:1..3078" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11371346]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23209026]" /experiment="EXISTENCE:direct assay:GO:0030690 Noc1p-Noc2p complex [PMID:11371346]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:9786894]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:23209026|PMID:11371346]" /note="Constituent of 66S pre-ribosomal particles; required for large (60S) ribosomal subunit biogenesis; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein" /db_xref="GeneID:851632" /db_xref="SGD:S000002467" ORIGIN 1 msenngnpld lsslrnkiss klrdnnskka kkthkgkdvk assnskkvne dirrealalg 61 aseedlkliq glsddddaks eqefdavade daddkgfknd lqnfmknvgf dqhkledvdd 121 ddieeestss keskipaqek ehaqsniass tiektsqesi dngseqeent veeanlssdq 181 epesesaeke kkeekdggli tqttiissdk liipydkpwy eipldpqvgq nddveelske 241 qieklfergk qtleadnqty yeeftkdssq akfmsqilsd gtlndkisav tlliqdsplh 301 ntksletlvs ycgkksrnsa lqslnalkdl flngllpnrk lryfknqpgl smmlnkktla 361 ifyfedylkk lffrvlevle vlshdpiihv rlqilnhvfd lltnqpeqef nllrlgvnki 421 gdidskvssk asylllkleq ahpnmksivi daivdialrp nadyhttyys vitlnqtilk 481 rsedsvankl vktyftlfek flintdkdnt ngvvksnsks yeekrkknfk kgkhggksvk 541 iektenevld eknsklfsal ltginrafpf aqipasvyev hmetlfkith ssnfntsiqa 601 lvlinqvtvk aklnsdryyr tlyeslfdpr lvnsskqgiy lnllykslkq dalnvervea 661 fvkrilqvcs hwlnvgtitg ffflliqlak tvpqiknllt ntpvdyeyes daeeeqgdkd 721 ikrkeydgrk rdpkfanaek sslweinnfi nhfhptvkty anayvtgete qiakpdlglf 781 tlshfldrfv yrsakqtnta rgtsimqplf sgsrvndsvl vkasdimhdq gpvntedwlt 841 kkvedikped kffyqyfttk ktadgkgkks nkasnfdsdd emdeneiwsa lvksrpdved 901 dsddseldfa eddfsdstsd depkldaidd edaksegsqe sdqeeglded ifysfdgeqd 961 nsdkkrsfae sseedessee ekeeeenkev sakrakkkqr knmlkslpvf asaddyaqyl 1021 dqdsd // LOCUS NP_010346 539 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR061W [Saccharomyces cerevisiae S288C]. ACCESSION NP_010346 VERSION NP_010346.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180369.3 REFERENCE 1 (residues 1 to 539) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 539) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 539) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 539) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11907. On Jul 30, 2012 this sequence version replaced NP_010346.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..539 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..539 /product="uncharacterized protein" /calculated_mol_wt="61061" Region <145..531 /region_name="PRK10938" /note="putative molybdenum transport ATP-binding protein ModF; Provisional" /db_xref="CDD:182852" CDS 1..539 /locus_tag="YDR061W" /coded_by="NM_001180369.3:1..1620" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]" /note="Protein with similarity to ABC transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance" /db_xref="GeneID:851633" /db_xref="SGD:S000002468" ORIGIN 1 mstnkfvvri tnalfkssla snsppvypkr irhfeilpne kwviwgpgkg kfldvlnnky 61 icepplslrf gflkessnil prieqvafkg vmptahlsar yeyfkddydq tckqfifdka 121 sgsnavsykv etnnrqinme lynalvenln lsslqdrwvm glsngqmrra rlarsilkep 181 dllliddpfl gldpaaiati sqflakydsi evsggcpivi glryqdtipa wcthiccvde 241 kngilfegpi eklqskmdet rsralkeleq lkkasnsked isindlicih pmygkkehei 301 ikmphlield glsvsykgea vlenlhwkvq pgskwhirgd ngsgkstlls lltaehpqsw 361 nsrvidngvp rrtgktnyfd lnskigmssp elhaiflkna ggrlniresv atgyheassn 421 nylpiwkrld knsqeivnmy lkyfgldkda dsvlfeqlsv sdqklvlfvr slikmpqili 481 ldeafsgmev epmmrchefl eewpgtvlvv ahvaeetpkc ahylrlispg eyeigdmen // LOCUS NP_010347 561 aa linear PLN 30-JUN-2025 DEFINITION serine C-palmitoyltransferase LCB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010347 VERSION NP_010347.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180370.1 REFERENCE 1 (residues 1 to 561) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 561) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 561) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 561) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11908. Method: conceptual translation. FEATURES Location/Qualifiers source 1..561 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..561 /product="serine C-palmitoyltransferase LCB2" /EC_number="2.3.1.50" /calculated_mol_wt="62980" Region 57..525 /region_name="AAT_I" /note="Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl18945" /db_xref="CDD:450240" Site order(163,224..226,250,302,306..307,331,333..334,363,366, 496) /site_type="active" /note="substrate-cofactor binding pocket [active]" /db_xref="CDD:99747" Site order(224..226,250,302,306,331,333..334,363,366) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99747" Site 366 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99747" CDS 1..561 /gene="LCB2" /locus_tag="YDR062W" /gene_synonym="SCS1; TSC1" /coded_by="NM_001180370.1:1..1686" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0017059 serine palmitoyltransferase complex [PMID:20182505]" /experiment="EXISTENCE:mutant phenotype:GO:0004758 serine C-palmitoyltransferase activity [PMID:1556076|PMID:8058731]" /experiment="EXISTENCE:mutant phenotype:GO:0017059 serine palmitoyltransferase complex [PMID:8058731]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:1556075|PMID:1556076]" /note="Serine palmitoyltransferase component; responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine" /db_xref="GeneID:851634" /db_xref="SGD:S000002469" ORIGIN 1 mstpanytrv plcepeelpd diqkeneygt ldspghlyqv ksrhgkplpe pvvdtppyyi 61 slltylnyli liilghvhdf lgmtfqknkh ldllehdgla pwfsnfesfy vrrikmridd 121 cfsrpttgvp grfircidri shnineyfty sgavypcmnl ssynylgfaq skgqctdaal 181 esvdkysiqs ggpraqigtt dlhikaeklv arfigkedal vfsmgygtna nlfnafldkk 241 clvisdelnh tsirtgvrls gaavrtfkhg dmvgleklir eqivlgqpkt nrpwkkilic 301 aeglfsmegt lcnlpklvel kkkykcylfi deahsigamg ptgrgvceif gvdpkdvdil 361 mgtftksfga aggyiaadqw iidrlrldlt tvsysesmpa pvlaqtissl qtisgeicpg 421 qgterlqria fnsrylrlal qrlgfivygv adspviplll ycpskmpafs rmmlqrriav 481 vvvaypatpl iesrvrfcms asltkedidy llrhvsevgd klnlksnsgk ssydgkrqrw 541 dieevirrtp edckddkyfv n // LOCUS NP_010348 149 aa linear PLN 30-JUN-2025 DEFINITION Aim7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010348 VERSION NP_010348.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180371.1 REFERENCE 1 (residues 1 to 149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 149) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11909. Method: conceptual translation. FEATURES Location/Qualifiers source 1..149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..149 /product="Aim7p" /calculated_mol_wt="16999" Region 7..136 /region_name="ADF_gelsolin" /note="Actin depolymerization factor/cofilin- and gelsolin-like domains; cl15697" /db_xref="CDD:472830" CDS 1..149 /gene="AIM7" /locus_tag="YDR063W" /gene_synonym="GMF1" /coded_by="NM_001180371.1:1..450" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:20362448]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:20362448]" /experiment="EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:20362448]" /experiment="EXISTENCE:direct assay:GO:0071846 actin filament debranching [PMID:20362448]" /note="Protein that interacts with the Arp2/3 complex; interaction with Arp2/3 stimulates actin filament debranching and inhibits actin nucleation; debranching activity is enhanced by Crn1p with which it forms a high affinity ternary complex (Crn1-Aim7-Arp2/3); sequence similarity to Cof1p and to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss" /db_xref="GeneID:851635" /db_xref="SGD:S000002470" ORIGIN 1 msnlykigte trnkikkfrt startdsika lsikiepkps yeiivdedeq eeldeiedls 61 elaeilpdns prfvltaypt ttkdgfkqtp lvlvywkpmt vvsqewkmly agalemiree 121 cgtfklievs sgleddsdve elreqlenc // LOCUS NP_010349 151 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS15 RPS13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010349 VERSION NP_010349.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180372.3 REFERENCE 1 (residues 1 to 151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 151) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11910. On Jul 30, 2012 this sequence version replaced NP_010349.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..151 /product="40S ribosomal protein uS15 RPS13" /calculated_mol_wt="16898" Region 4..151 /region_name="PTZ00072" /note="40S ribosomal protein S13; Provisional" /db_xref="CDD:185427" CDS 1..151 /gene="RPS13" /locus_tag="YDR064W" /gene_synonym="RPS13B; RPS13C" /coded_by="NM_001180372.3:1..456" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480|PMID:2517480|PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:2517480|PMID:3533916|PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:2517480]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15" /db_xref="GeneID:851636" /db_xref="SGD:S000002471" ORIGIN 1 mgrmhsagkg isssaipysr napawfklss esvieqivky arkgltpsqi gvllrdahgv 61 tqarvitgnk imrilksngl apeipedlyy likkavsvrk hlernrkdkd akfrlilies 121 rihrlaryyr tvavlppnwk yesatasalv n // LOCUS NP_010350 365 aa linear PLN 30-JUN-2025 DEFINITION Rrg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010350 VERSION NP_010350.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180373.3 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11911. On Jul 30, 2012 this sequence version replaced NP_010350.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..365 /product="Rrg1p" /calculated_mol_wt="42698" CDS 1..365 /gene="RRG1" /locus_tag="YDR065W" /gene_synonym="MTA2" /coded_by="NM_001180373.3:1..1098" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0099617 matrix side of mitochondrial inner membrane [PMID:30759361]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:19751518]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:16168084]" /experiment="EXISTENCE:mutant phenotype:GO:0097745 mitochondrial tRNA 5'-end processing [PMID:30759361]" /note="hypothetical protein; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; required for vacuolar acidification; localizes to the matrix side of the inner mitochondrial membrane" /db_xref="GeneID:851637" /db_xref="SGD:S000002472" ORIGIN 1 maqnfgkips hksyvlslyr tvlrnipkcc hsyafqyeik ktlsiqlfkh khdksswsvy 61 tllnefslln ncllegklqe iknlmkplkk mkkqlkttki lnsltslgdv ktndpeevrr 121 fhvlsayikr kqdlgllpay ipktyqhkll lplalnehac lklfhiqqkl kngppsagls 181 ytkegrnqiw fvrspinkgr qqskklgili rkerkdsqkn idnlnfcein aawalheaiw 241 eeyleskkii kvnlpkyley aanipkstkc npssqyqkvk ewvdpvreim felhsksfqr 301 veyfnkykek llknggqlay fdkkskemya krltlfrkms ketlpyvtlf iegrdlpsvl 361 akygf // LOCUS NP_010351 196 aa linear PLN 30-JUN-2025 DEFINITION putative protein-serine/threonine phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010351 VERSION NP_010351.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180374.1 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11912. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..196 /product="putative protein-serine/threonine phosphatase" /EC_number="3.1.3.16" /calculated_mol_wt="22410" Region 55..115 /region_name="RPAP2_Rtr1" /note="Rtr1/RPAP2 family; pfam04181" /db_xref="CDD:461212" CDS 1..196 /gene="RTR2" /locus_tag="YDR066C" /coded_by="NM_001180374.1:1..591" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /note="hypothetical protein; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; RTR2 has a paralog, RTR1, that arose from the whole genome duplication" /db_xref="GeneID:851638" /db_xref="SGD:S000002473" ORIGIN 1 mqiitttfiq kvilgshqlh eqlsivearm iesaivsmlt esfceneqtl kylarllspm 61 symdvinarr gkkicgyplc yksaaenssd gffihsmycn nyhskcslyl mrqlsqtplh 121 errgvhltsy inlefddmys vslleelvgs evpidtvksl itsfkdlefd dtykneplpl 181 dvyfgqlttd eetcie // LOCUS NP_010352 224 aa linear PLN 30-JUN-2025 DEFINITION protein-tyrosine-phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010352 VERSION NP_010352.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180375.1 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11913. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..224 /product="protein-tyrosine-phosphatase" /EC_number="3.1.3.48" /calculated_mol_wt="25893" Region 4..181 /region_name="PFA-DSP_Oca6" /note="atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6; cd17663" /db_xref="CDD:350501" CDS 1..224 /gene="OCA6" /locus_tag="YDR067C" /coded_by="NM_001180375.1:1..675" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic protein required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT" /db_xref="GeneID:851639" /db_xref="SGD:S000002474" ORIGIN 1 mtlvtplqfs tvqpnlyrgs ypreinlpfl rtlrlkyils ltpeplstdp lmvkfceenn 61 iktihikcqs erkadktkpk ikrkkktvpi eydvvvrcvk flidkghypc ymhctngeli 121 islvvacmrk fsywstvsil neflvynssi nihernfien fnseievddl dikdkvpwit 181 vryiartate skdelrvdda nasekvarvs svsnslpklk fhsm // LOCUS NP_010353 310 aa linear PLN 30-JUN-2025 DEFINITION Dos2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010353 VERSION NP_010353.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180376.3 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11914. On Jul 30, 2012 this sequence version replaced NP_010353.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..310 /product="Dos2p" /calculated_mol_wt="35833" Region 180..232 /region_name="BSD" /note="BSD domain; pfam03909" /db_xref="CDD:461089" CDS 1..310 /gene="DOS2" /locus_tag="YDR068W" /coded_by="NM_001180376.3:1..933" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:851640" /db_xref="SGD:S000002475" ORIGIN 1 meffyeeqva cieddkisns htketgsten tennelqsrd dktneafqkl eeevnkryek 61 ttsafkklvi ekddgieinl pisnetteta qkylkklden ihsveslaqs ywskmktknf 121 wsgfssfdna aendsndkde nskeneiavg gnrteaelrt lskdksvyld nkmdlqldpf 181 dvdekteeic silqgdkdis klmndivphk isykdfwhiy flqrnkildk eskrkeilsk 241 keketeekev ewddeeeeed ddkveavadn kskgetkvav sqeglkdvsd hvglankdes 301 kdddddddwe // LOCUS NP_010354 926 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease DOA4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010354 VERSION NP_010354.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180377.3 REFERENCE 1 (residues 1 to 926) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 926) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 926) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 926) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 926) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 926) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 926) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 926) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 926) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11915. On Jul 30, 2012 this sequence version replaced NP_010354.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..926 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..926 /product="ubiquitin-specific protease DOA4" /EC_number="3.4.19.12" /calculated_mol_wt="105061" Region 208..324 /region_name="RHOD" /note="Rhodanese Homology Domain; smart00450" /db_xref="CDD:197731" Site 275 /site_type="active" /note="active site residue [active]" /db_xref="CDD:238089" Region 562..920 /region_name="UCH" /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443" /db_xref="CDD:425685" Site order(566,571,880,898) /site_type="active" /db_xref="CDD:239139" CDS 1..926 /gene="DOA4" /locus_tag="YDR069C" /gene_synonym="DOS1; MUT4; NPI2; SSV7; UBP4" /coded_by="NM_001180377.3:1..2781" /experiment="EXISTENCE:direct assay:GO:0000502 proteasome complex [PMID:10069815]" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:19410548|PMID:8247125]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:17145966]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010995 free ubiquitin chain depolymerization [PMID:19410548]" /experiment="EXISTENCE:genetic interaction:GO:0070676 intralumenal vesicle formation [PMID:23444383]" /experiment="EXISTENCE:mutant phenotype:GO:0004843 cysteine-type deubiquitinase activity [PMID:8247125]" /experiment="EXISTENCE:mutant phenotype:GO:0006275 regulation of DNA replication [PMID:8657109]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:17145966]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:9119204]" /experiment="EXISTENCE:mutant phenotype:GO:0010992 ubiquitin recycling [PMID:19410548]" /experiment="EXISTENCE:mutant phenotype:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:17376168]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /note="Ubiquitin hydrolase; deubiquitinates intralumenal vesicle (ILVs) cargo proteins; required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins destined for the vacuole; DOA4 has a paralog, UBP5, that arose from the whole genome duplication" /db_xref="GeneID:851641" /db_xref="SGD:S000002476" ORIGIN 1 meqniistir decirhrsky ltiaqltaia eakinefiit gkakdqdlss lldkcidils 61 iykknskdik niiscknkga missnsvmii qlnyvyykvi hiivttniph lsefakiklh 121 kstsdegngn nnnnefqlmn iyntlletll kdeniakiks fikssikqtk lnheqeecnl 181 mrtgsyitsn qlnslisssa nsassqmeil lidirsrlef nkshidtkni iclepisfkm 241 sysdhdlekk slitspnsei kmfqsrnlfk fiilytdane ynvkqqsvll dilvnhsfek 301 pisddftkif ilesgfpgwl ksnygrqvss sfpsnnnikd dsvyingnts glslqhlpkm 361 spsirhsmdd smkemlvapt plnhlqqqqq qqsdndhvlk rsssfkklfs nytspnpkns 421 nsnlysissl sissspsplp lhspdpvkgn slpinypetp hlwknsetdf mtnqreqlnh 481 nsfahiapin tkaitspsrt atpklqrfpq tismnlnmns nghssatsti qpsclslsnn 541 dsldhtdvtp tsshnydldf avglenlgns cymnciiqci lgtheltqif lddsyakhin 601 insklgskgi lakyfarlvh mmykeqvdgs kkisispikf klacgsvnsl fktasqqdcq 661 efcqflldgl hedlnqcgsn pplkelsqea earreklslr iassiewerf lttdfsvivd 721 lfqgqyasrl kckvcshtst tyqpftvlsi pipkknsrnn itiedcfref tkcenlevde 781 qwlcphcekr qpstkqltit rlprnlivhl krfdnllnkn ndfviypfll dltpfwandf 841 dgvfppgvnd delpirgqip pfkyelygva chfgtlyggh ytayvkkglk kgwlyfddtk 901 ykpvknkada insnayvlfy hrvygv // LOCUS NP_010355 93 aa linear PLN 30-JUN-2025 DEFINITION Fmp16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010355 VERSION NP_010355.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180378.1 REFERENCE 1 (residues 1 to 93) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 93) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 93) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 93) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11916. Method: conceptual translation. FEATURES Location/Qualifiers source 1..93 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..93 /product="Fmp16p" /calculated_mol_wt="10714" CDS 1..93 /gene="FMP16" /locus_tag="YDR070C" /coded_by="NM_001180378.1:1..282" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:14562095]" /note="hypothetical protein; may be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851642" /db_xref="SGD:S000002477" ORIGIN 1 mlrttflrtp rqlmrkspra sfsivtraaf phlknnqdea ekkeqglfds nkkrldtleh 61 gknpdykqpg medlkkkgdd arieqnrpdd gvy // LOCUS NP_010356 191 aa linear PLN 30-JUN-2025 DEFINITION polyamine acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010356 VERSION NP_010356.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180379.1 REFERENCE 1 (residues 1 to 191) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 191) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 191) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 191) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11917. Method: conceptual translation. FEATURES Location/Qualifiers source 1..191 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..191 /product="polyamine acetyltransferase" /calculated_mol_wt="21816" Region 14..162 /region_name="yhbS" /note="Predicted N-acetyltransferase YhbS [General function prediction only]; COG3153" /db_xref="CDD:442387" CDS 1..191 /gene="PAA1" /locus_tag="YDR071C" /coded_by="NM_001180379.1:1..576" /experiment="EXISTENCE:direct assay:GO:0004059 aralkylamine N-acetyltransferase activity [PMID:11559708]" /experiment="EXISTENCE:direct assay:GO:0004145 diamine N-acetyltransferase activity [PMID:15723835]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004145 diamine N-acetyltransferase activity [PMID:15723835]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:15723835]" /note="Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication" /db_xref="GeneID:851643" /db_xref="SGD:S000002478" ORIGIN 1 masssstlpl hmyirpliie dlkqilnles qgfppneras eeiisfrlin cpelcsglfi 61 reiegkevkk etlighimgt kipheyitie smgklqvess nhigihsvvi kpeyqkknla 121 tllltdyiqk lsnqeignki vliaheplip fyervgfkii aentnvakdk nfaeqkwidm 181 erelikeeyd n // LOCUS NP_010357 527 aa linear PLN 30-JUN-2025 DEFINITION inositolphosphotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010357 VERSION NP_010357.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180380.3 REFERENCE 1 (residues 1 to 527) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 527) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 527) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 527) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11918. On Jul 30, 2012 this sequence version replaced NP_010357.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..527 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..527 /product="inositolphosphotransferase" /EC_number="2.7.1.228" /calculated_mol_wt="60742" Region 162..>316 /region_name="PAP2_Aur1_like" /note="PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; cd03386" /db_xref="CDD:239481" CDS 1..527 /gene="IPT1" /locus_tag="YDR072C" /gene_synonym="KTI6; MIC2; SYR4" /coded_by="NM_001180380.3:1..1584" /experiment="EXISTENCE:direct assay:GO:0006676 mannosyl diphosphorylinositol ceramide metabolic process [PMID:9368028]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:6991492]" /experiment="EXISTENCE:direct assay:GO:0016772 transferase activity, transferring phosphorus-containing groups [PMID:9368028]" /experiment="EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:20030721]" /experiment="EXISTENCE:genetic interaction:GO:0030148 sphingolipid biosynthetic process [PMID:15792805]" /note="Inositolphosphotransferase; involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid; can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin" /db_xref="GeneID:851644" /db_xref="SGD:S000002479" ORIGIN 1 mnvifslasf vknmynasln qrnlislpfn fmlnfapvfi wlsifkragl ipirlrpdih 61 skfaffadqf lfgdywhelt vqlpdntskl ffwsfisssa fllvflicip faiwyyiyyi 121 khvnynllew fanifhypck rkqrpiqkrf rtifipfalp lftfvilnid hffayqsdan 181 ftktkdllaw fsyvilhlta piltavylyv fqppgtlkcf sfalglqnia gvlthllvpm 241 aspwfthlyg iddtehvnyt qegfaaglir vdshlgthln tkgfhmspiv fgavpslhsa 301 iafqcflflv srstslkhrf snaggftmhn ndsstfklse edsedegdns ipptigpndl 361 emeplgtvep vdisnersss psssftvssn erstgggdgs iinsngnkkp lqfvhlyded 421 tnftnkwifk ivndgfipkf wailyiilqw watmyldhhy rfdlfvgvly amtsfiiinw 481 fvlqpkvlkk wihirlgdkv dtrneartfg mrvfcgtkme wffdpla // LOCUS NP_010358 169 aa linear PLN 30-JUN-2025 DEFINITION Snf11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010358 VERSION NP_010358.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180381.3 REFERENCE 1 (residues 1 to 169) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 169) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 169) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 169) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11919. On Jul 30, 2012 this sequence version replaced NP_010358.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..169 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..169 /product="Snf11p" /calculated_mol_wt="18536" CDS 1..169 /gene="SNF11" /locus_tag="YDR073W" /coded_by="NM_001180381.3:1..510" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:18644858|PMID:7623818]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17573544]" /note="Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions" /db_xref="GeneID:851645" /db_xref="SGD:S000002480" ORIGIN 1 msseiaysnt ntntenenrn tgagvdvntn anananatan atanatanat aelnlptvde 61 qrqykvqlll hinsillarv iqmnnslqnn lqnninnsnn nniiriqqli sqflkrvhan 121 lqcisqinqg vpsakplilt ppqlanqqqp pqdilsklyl llarvfeiw // LOCUS NP_010359 896 aa linear PLN 30-JUN-2025 DEFINITION trehalose-phosphatase TPS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010359 VERSION NP_010359.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180382.1 REFERENCE 1 (residues 1 to 896) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 896) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 896) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 896) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 896) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 896) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 896) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 896) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 896) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11920. Method: conceptual translation. FEATURES Location/Qualifiers source 1..896 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..896 /product="trehalose-phosphatase TPS2" /EC_number="3.1.3.12" /calculated_mol_wt="102846" Region 61..541 /region_name="Glyco_transf_20" /note="Glycosyltransferase family 20; pfam00982" /db_xref="CDD:425972" Region 569..848 /region_name="T6PP" /note="trehalose-phosphatase; TIGR00685" /db_xref="CDD:273219" Site order(577..581,584..585,589,617..619,641,685,687,692,694, 696,729,731,733,741,780..781,784..785) /site_type="active" /db_xref="CDD:319767" Site order(577..581,585,589,617..619,621,626..627,640..641,685, 687,692,694,729,731,733,735,741,780..782,784..785) /site_type="active" /note="active site pocket [active]" /db_xref="CDD:319767" CDS 1..896 /gene="TPS2" /locus_tag="YDR074W" /gene_synonym="HOG2; PFK3" /coded_by="NM_001180382.1:1..2691" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0004805 trehalose-phosphatase activity [PMID:8444170|PMID:9837904]" /experiment="EXISTENCE:mutant phenotype:GO:0005991 trehalose metabolic process [PMID:9837904]" /experiment="EXISTENCE:mutant phenotype:GO:0005992 trehalose biosynthetic process [PMID:8203161|PMID:8444170]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:32240040]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:32240040]" /experiment="EXISTENCE:physical interaction:GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [PMID:9837904]" /note="Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in the synthesis of storage carbohydrate trehalose; positive regulator of autophagy involved in the dephosphorylation of Rim15p leading to ATG8 induction; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851646" /db_xref="SGD:S000002481" ORIGIN 1 mtttaqdnsp kkrqriincv tqlpykiqlg esnddwkisa ttgnsalfss leylqfdste 61 yeqhvvgwtg eitrternlf treakekpqd ldddplyltk eqingltttl qdhmksdkea 121 ktdttqtapv tnnvhpvwll rknqsrwrny aekviwptfh yilnpsnege qeknwwydyv 181 kfneayaqki gevyrkgdii wihdyyllll pqllrmkfnd esiiigyfhh apwpsneyfr 241 clprrkqild glvganricf qnesfsrhfv ssckrlldat akksknssns dqyqvsvygg 301 dvlvdslpig vnttqilkda ftkdidskvl sikqayqnkk iiigrdrlds vrgvvqklra 361 fetflamype wrdqvvliqv ssptanrnsp qtirleqqvn elvnsinsey gnlnfspvqh 421 yymripkdvy lsllrvadlc litsvrdgmn ttaleyvtvk shmsnflcyg nplilsefsg 481 ssnvlkdaiv vnpwdsvava ksinmalkld keeksnlesk lwkevptiqd wtnkflsslk 541 eqassnddme rkmtpalnrp vllenykqak rrlflfdydg tltpivkdpa aaipsarlyt 601 ilqklcadph nqiwiisgrd qkflnkwlgg klpqlglsae hgcfmkdvsc qdwvnltekv 661 dmswqvrvne vmeefttrtp gsfierkkva ltwhyrrtvp elgefhakel kekllsftdd 721 fdlevmdgka nievrprfvn kgeivkrlvw hqhgkpqdml kgiseklpkd empdfvlclg 781 ddftdedmfr qlntietcwk ekypdqknqw gnygfypvtv gsaskktvak ahltdpqqvl 841 etlgllvgdv slfqsagtvd ldsrghvkns esslksklas kayvmkrsas ytgakv // LOCUS NP_010360 308 aa linear PLN 30-JUN-2025 DEFINITION phosphoprotein phosphatase PP4 catalytic subunit PPH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010360 VERSION NP_010360.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180383.1 REFERENCE 1 (residues 1 to 308) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 308) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 308) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 308) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11921. Method: conceptual translation. FEATURES Location/Qualifiers source 1..308 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..308 /product="phosphoprotein phosphatase PP4 catalytic subunit PPH3" /EC_number="3.1.3.16" /calculated_mol_wt="35133" Region 3..286 /region_name="MPP_PP2A_PP4_PP6" /note="PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain; cd07415" /db_xref="CDD:277360" Site order(45,61,64..65,67..68,70,72..73,85,100..104,115..116, 119..120,124..125,128..129,137,262,271,281) /site_type="other" /note="heterotrimer interface [polypeptide binding]" /db_xref="CDD:277360" Site order(51,53,79,83,111..112,116..117,121,161,183..185,194, 207..209,235,237,261..263) /site_type="active" /db_xref="CDD:277360" Site order(51,53,79,111,161,235) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277360" CDS 1..308 /gene="PPH3" /locus_tag="YDR075W" /coded_by="NM_001180383.1:1..927" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:7941742|PMID:16299494]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030289 protein phosphatase 4 complex [PMID:16299494|PMID:17517611]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:21135129]" /experiment="EXISTENCE:genetic interaction:GO:1903432 regulation of TORC1 signaling [PMID:12820961]" /experiment="EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:16299494]" /experiment="EXISTENCE:mutant phenotype:GO:0019222 regulation of metabolic process [PMID:10940301]" /experiment="EXISTENCE:mutant phenotype:GO:0030289 protein phosphatase 4 complex [PMID:16299494]" /experiment="EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:20951350]" /experiment="EXISTENCE:mutant phenotype:GO:1902660 negative regulation of glucose mediated signaling pathway [PMID:24277933]" /experiment="EXISTENCE:mutant phenotype:GO:2000002 negative regulation of DNA damage checkpoint [PMID:17517611|PMID:16299494]" /experiment="EXISTENCE:mutant phenotype:GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining [PMID:24498054]" /note="Catalytic subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form active complex, Psy4p may provide substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes" /db_xref="GeneID:851647" /db_xref="SGD:S000002482" ORIGIN 1 mmdldkiias lrdgkhipee tvfrlclnsq ellmnegnvt qvdtpvticg dihgqlhdll 61 tlfeksggve ktryiflgdf vdrgfysles fllllcyklr ypdritlirg nhetrqitkv 121 ygfydevvrk ygnsnvwryc cevfdylslg aiinnsifcv hgglspdmtt vdeirtidrk 181 qevphegamc dllwsdpedv dtwslsprga gflfgkrevd qfleknnvel iarahqlvme 241 gykemfdggl vtvwsapnyc yrcgnvaavl kidddlnrey tifeavqaqn evgnaiiptk 301 ksqmdyfl // LOCUS NP_010361 406 aa linear PLN 30-JUN-2025 DEFINITION putative DNA-dependent ATPase RAD55 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010361 VERSION NP_010361.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180384.3 REFERENCE 1 (residues 1 to 406) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 406) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 406) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 406) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11922. On Jul 30, 2012 this sequence version replaced NP_010361.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..406 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..406 /product="putative DNA-dependent ATPase RAD55" /calculated_mol_wt="46219" Region 18..>138 /region_name="RAD55" /note="RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms]; COG0467" /db_xref="CDD:440235" CDS 1..406 /gene="RAD55" /locus_tag="YDR076W" /coded_by="NM_001180384.3:1..1221" /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:9159392]" /experiment="EXISTENCE:direct assay:GO:0033065 Rad51C-XRCC3 complex [PMID:9159392]" /experiment="EXISTENCE:mutant phenotype:GO:0000707 meiotic DNA recombinase assembly [PMID:9679065]" /experiment="EXISTENCE:mutant phenotype:GO:0000730 DNA recombinase assembly [PMID:12887906|PMID:14765116|PMID:11459983]" /note="Protein that stimulates strand exchange; stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p" /db_xref="GeneID:851648" /db_xref="SGD:S000002483" ORIGIN 1 mslgiplsql ivespkplss gitgldeiln lgfqarsiye ifgppgigkt nfgiqlvcns 61 legiqqsein ddkilwietf qempinilre rfqkfkivee nvkrvritkf gqllyffqnl 121 fklsqsvryk lviidgfsql vcdhlctlsk rgggmidkti helkcrhlil iftvmtkyth 181 stgstiivln dcmntafqsn efesleeyye ilddgsnffv nsnnerrknn vhilksalva 241 niamgskdst wevflrdrig lfrdwneqvd etvfvkskrv kasssqsneg cttikemrin 301 krnfenlria ivfnlhgedr kregrnlkrs rssddrnyiv kfdfdkatgq lrdiidlkpd 361 taniasfptl stsssscsqv fnnidsndnp lpnaegkeei iydseg // LOCUS NP_010362 338 aa linear PLN 30-JUN-2025 DEFINITION Sed1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010362 VERSION NP_010362.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180385.3 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11923. On Jul 30, 2012 this sequence version replaced NP_010362.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..338 /product="Sed1p" /calculated_mol_wt="34300" CDS 1..338 /gene="SED1" /locus_tag="YDR077W" /coded_by="NM_001180385.3:1..1017" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15351639]" /experiment="EXISTENCE:direct assay:GO:0005840 ribosome [PMID:12627396]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9613572]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:15351639]" /experiment="EXISTENCE:mutant phenotype:GO:0005199 structural constituent of cell wall [PMID:9642191]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:9642191]" /note="Major stress-induced structural GPI-cell wall glycoprotein; associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites; SED1 has a paralog, SPI1, that arose from the whole genome duplication" /db_xref="GeneID:851649" /db_xref="SGD:S000002484" ORIGIN 1 mklstvllsa glasttlaqf snstsasstd vtssssists sgsvtitsse apesdngtst 61 aaptetstea pttaiptngt steapttaip tngtsteapt dttteaptta lptngtstea 121 ptdttteapt tglptngtts afppttslpp snttttppyn pstdyttdyt vvteyttycp 181 epttfttngk tytvtepttl titdcpctie kptttsttey tvvteyttyc pepttfttng 241 ktytvteptt ltitdcpcti ekseapessv pvteskgttt ketgvttkqt tanpsltvst 301 vvpvsssass hsvvinsnga nvvvpgalgl agvamlfl // LOCUS NP_010363 223 aa linear PLN 30-JUN-2025 DEFINITION Shu2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010363 VERSION NP_010363.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180386.1 REFERENCE 1 (residues 1 to 223) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 223) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 223) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 223) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11924. Method: conceptual translation. FEATURES Location/Qualifiers source 1..223 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..223 /product="Shu2p" /calculated_mol_wt="25992" CDS 1..223 /gene="SHU2" /locus_tag="YDR078C" /coded_by="NM_001180386.1:1..672" /experiment="EXISTENCE:direct assay:GO:0097196 Shu complex [PMID:23575680]" /experiment="EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:15654096]" /experiment="EXISTENCE:genetic interaction:GO:0043007 maintenance of rDNA [PMID:21372173]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:23575680]" /experiment="EXISTENCE:mutant phenotype:GO:0000730 DNA recombinase assembly [PMID:23575680]" /experiment="EXISTENCE:mutant phenotype:GO:0035861 site of double-strand break [PMID:23575680]" /experiment="EXISTENCE:physical interaction:GO:0097196 Shu complex [PMID:15654096]" /note="Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu1, and promotes error-free DNA repair, Shu complex mediates inhibition of Srs2p function; promotes formation of Rad51p filaments; important for both mitotic and meiotic homologous recombination, and contains a conserved SWIM domain that is necessary for both" /db_xref="GeneID:851650" /db_xref="SGD:S000002485" ORIGIN 1 mskdvieysk lfaklvntnd dtklddtias flyymfprel firaislles sdmfiyildr 61 vhnkegneht slidvlvdef ykgssnslle yrlivkdtnd gappilvdia hwfcsceefc 121 kyfhealekt dekeelhdvl inevddhlqf sddrfaqldp hslskqwyfk fdkvccshll 181 afsillrssi nvlkfftvns nkvfviaidn idewlnlhin ive // LOCUS NP_010364 111 aa linear PLN 30-JUN-2025 DEFINITION Pet100p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010364 VERSION NP_010364.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180387.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11925. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..111 /product="Pet100p" /calculated_mol_wt="13056" Region 15..78 /region_name="Pet100" /note="pfam09803" /db_xref="CDD:462908" CDS 1..111 /gene="PET100" /locus_tag="YDR079W" /coded_by="NM_001180387.1:1..336" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11498004|PMID:15507444]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:11498004]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:15507444|PMID:11498004]" /note="Chaperone that facilitates the assembly of cytochrome c oxidase; integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme" /db_xref="GeneID:851651" /db_xref="SGD:S000002486" ORIGIN 1 mglfnnfkfk ytraqleifr fsfcllapva vmyyigtdtd kklnvpgfwp dpatlnqipk 61 epyeikaela rmkkerlekr lrlekkiqee fgldleeeke kikrdlalkk g // LOCUS NP_076886 72 aa linear PLN 30-JUN-2025 DEFINITION TFIIH complex subunit TFB5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_076886 VERSION NP_076886.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184469.3 REFERENCE 1 (residues 1 to 72) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 72) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 72) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 72) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11926. On Jul 30, 2012 this sequence version replaced NP_076886.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..72 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..72 /product="TFIIH complex subunit TFB5" /calculated_mol_wt="8101" Region 1..65 /region_name="Tfb5" /note="Transcription factor TFIIH complex subunit Tfb5; pfam06331" /db_xref="CDD:428891" CDS 1..72 /gene="TFB5" /locus_tag="YDR079C-A" /coded_by="NM_001184469.3:1..219" /experiment="EXISTENCE:curator inference:GO:0000993 RNA polymerase II complex binding [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:15220919|PMID:27381459]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:30905750]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:17215295]" /experiment="EXISTENCE:physical interaction:GO:0000439 transcription factor TFIIH core complex [PMID:17215295]" /note="Component of RNA polymerase II general transcription factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; relocalizes to the cytosol in response to hypoxia; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair" /db_xref="GeneID:851652" /db_xref="SGD:S000007603" ORIGIN 1 mararkgalv qcdpsikali lqidakmsdi vleelddthl lvnpskvefv khelnrllsk 61 niynpmdeee nq // LOCUS NP_010365 992 aa linear PLN 30-JUN-2025 DEFINITION Vps41p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010365 VERSION NP_010365.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180388.3 REFERENCE 1 (residues 1 to 992) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 992) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 992) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 992) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 992) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 992) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 992) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 992) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 992) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11927. On Jul 30, 2012 this sequence version replaced NP_010365.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..992 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..992 /product="Vps41p" /calculated_mol_wt="113281" Region 145..179 /region_name="WD40" /note="WD40 repeats; smart00320" /db_xref="CDD:197651" Region <146..>223 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 753..896 /region_name="CLH" /note="Clathrin heavy chain repeat homology; smart00299" /db_xref="CDD:128594" CDS 1..992 /gene="VPS41" /locus_tag="YDR080W" /gene_synonym="CVT8; FET2; SVL2; VAM2; VPL20" /coded_by="NM_001180388.3:1..2979" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:9111041]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:16601699]" /experiment="EXISTENCE:direct assay:GO:0035542 regulation of SNARE complex assembly [PMID:18385512]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:direct assay:GO:0099022 vesicle tethering [PMID:27307091]" /experiment="EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:9159129]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:9111041]" /experiment="EXISTENCE:mutant phenotype:GO:0015031 protein transport [PMID:9184222]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:12730205]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:physical interaction:GO:0030897 HOPS complex [PMID:10944212]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:21325627|PMID:20604902|PMID:18809726]" /note="Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting specifically with the GTP-bound conformation of Ypt7p, facilitating tethering, docking and promoting membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; Yck3p-mediated phosphorylation regulates the organization of vacuolar fusion sites" /db_xref="GeneID:851653" /db_xref="SGD:S000002487" ORIGIN 1 mttdnhqnds vldqqsgert idesnsisde nnvdnkredv nvtsptksvs cisqaengva 61 srtdestitg satdaetgdd ddddddddde deddedeppl lkytrisqlp knffqrdsis 121 sclfgdtffa fgthsgilhl ttcafepikt ikchrssilc intdgkyfat gsidgtviig 181 smddpqnitq ydfkrpinsv alhsnfqasr mfvsggmagd vvlsqrnwlg nridivlnkk 241 kkkktrkddl ssdmkgpimg iytmgdlilw mdddgitfcd vptrsqllni pfpsrifnvq 301 dvrpdlfrph vhflesdrvv igwgsniwlf kvsftkdsns iksgdsnsqs nnmshfnptt 361 nigsllssaa ssfrgtpdkk velechftvs mlitglasfk ddqllclgfd idieeeatid 421 edmkegknfs krpenllakg napelkivdl fngdeiynde vimknyekls indyhlgkhi 481 dkttpeyyli ssndairvqe lslkdhfdwf merkqyykaw kigkyvigse erfsiglkfl 541 nslvtkkdwg tlvdhlniif eetlnsldsn sydvtqnvlk ewadiieili tsgniveiap 601 lipkkpalrk svyddvlhyf landminkfh eyitkwdlkl fsvedfeeel etrieaasep 661 tasskeegsn ityrtelvhl ylkenkytka iphllkakdl raltiikiqn llpqyldqiv 721 diillpykge ishisklsif eiqtifnkpi dllfenrhti svariyeife hdcpksfkki 781 lfcylikfld tddsfmispy enqlielyse ydrqsllpfl qkhnnynves aievcssklg 841 lyneliylwg kigetkkals liidelknpq laidfvknwg dselwefmin ysldkpnftk 901 ailtcsdets eiylkvirgm sddlqidnlq diikhivqen slslevrdni lviindetkk 961 faneflkirs qgklfqvdes dieinddlng vl // LOCUS NP_010366 925 aa linear PLN 30-JUN-2025 DEFINITION Pdc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010366 VERSION NP_010366.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180389.1 REFERENCE 1 (residues 1 to 925) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 925) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 925) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 925) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 925) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 925) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 925) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 925) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 925) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11928. Method: conceptual translation. FEATURES Location/Qualifiers source 1..925 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..925 /product="Pdc2p" /calculated_mol_wt="103814" Region 72..135 /region_name="HTH_Tnp_Tc5" /note="Tc5 transposase DNA-binding domain; pfam03221" /db_xref="CDD:460850" Region 198..406 /region_name="DDE_1" /note="DDE superfamily endonuclease; pfam03184" /db_xref="CDD:367380" Region <716..829 /region_name="PLN02217" /note="probable pectinesterase/pectinesterase inhibitor" /db_xref="CDD:215130" CDS 1..925 /gene="PDC2" /locus_tag="YDR081C" /coded_by="NM_001180389.1:1..2778" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:22404710]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:22404710]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:19013460]" /experiment="EXISTENCE:genetic interaction:GO:0090180 positive regulation of thiamine biosynthetic process [PMID:16850348]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8264540]" /experiment="EXISTENCE:mutant phenotype:GO:0090180 positive regulation of thiamine biosynthetic process [PMID:16850348]" /experiment="EXISTENCE:mutant phenotype:GO:2001172 positive regulation of glycolytic fermentation to ethanol [PMID:8264540]" /note="Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions" /db_xref="GeneID:851654" /db_xref="SGD:S000002488" ORIGIN 1 mlsiqqryni clmaerhpkw tqlelakway etfqlpkips qgtisrllar kstymnckeh 61 ekdanrlrkp nnllvrkilq ewisqslwng ipitspiiqd taqavwhrip aehregngsf 121 sykwisnfls kmdvnisvld eelpktpkvw tfeerdvlka yfskippkdl ftldeaflsy 181 nlpldyaqye assiqrriev atvmlcsnld gseklkpvvv gkydsyksfr nyfpnepndp 241 vsqsmlgtkm akkfdisyhs nrkawltsnl fhnwlvrwdk rlvavnrkiw ivlddscchr 301 iinlrlqnik lvytssnskf lpfnwgvwde fktryriqqy qalidlqnri skniqnknks 361 ernecipngk kclisfeqsq ltmsnafkfi kkawddipvd aikanwkssg llppemihln 421 envsmafkkn evlesvlnrl cdeyycvkkw eyemlldlni enkntnflst eelvesaive 481 pcepdfdtap kgnevhddnf dvsvfanedd nnqnhlsmsq ashnpdynsn hsnnaientn 541 nrgsnnnnnn ngssnnindn dssvkylqqn tvdnstktgn pgqpnissme sqrnssttdl 601 vvdgnydvnf ngllndpynt mkqpgpldyn vstlidkpnl flspdldlst vgvdmqlpss 661 eyfsevfssa irnnekaasd qnkstdelps stamansnsi ttallesrnq aqpfdvphmn 721 gllsdtsksg hsvnssnais qnslnnfqhn sasvaeassp sitpspvain stgaparsii 781 sapidsnssa sspsalehle gavsgmspss ttilsnlqtn iniakslsti mkhaesneis 841 ltketineln fnyltllkri kktrkqlnse sikinsknaq dhletllsga aaaaatsann 901 ldlptggsnl pdsnnlhlpg ntgff // LOCUS NP_010367 494 aa linear PLN 30-JUN-2025 DEFINITION Stn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010367 VERSION NP_010367.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180390.1 REFERENCE 1 (residues 1 to 494) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 494) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 494) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 494) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11929. Method: conceptual translation. FEATURES Location/Qualifiers source 1..494 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..494 /product="Stn1p" /calculated_mol_wt="57380" Region 11..261 /region_name="Stn1" /note="Telomere regulation protein Stn1; pfam10451" /db_xref="CDD:371062" Region 319..489 /region_name="Stn1_C" /note="Telomere capping C-terminal wHTH; pfam12659" /db_xref="CDD:463659" CDS 1..494 /gene="STN1" /locus_tag="YDR082W" /coded_by="NM_001180390.1:1..1485" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17293872]" /experiment="EXISTENCE:direct assay:GO:0061770 translation elongation factor binding [PMID:31006804]" /experiment="EXISTENCE:genetic interaction:GO:0016233 telomere capping [PMID:9042864|PMID:15132993]" /experiment="EXISTENCE:genetic interaction:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:17947422]" /experiment="EXISTENCE:mutant phenotype:GO:0016233 telomere capping [PMID:15132993|PMID:9042864]" /experiment="EXISTENCE:mutant phenotype:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:17947422]" /experiment="EXISTENCE:physical interaction:GO:0016233 telomere capping [PMID:15132993|PMID:9042864]" /experiment="EXISTENCE:physical interaction:GO:1990879 CST complex [PMID:11230140|PMID:9042864]" /note="Telomere end-binding and capping protein; plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping; similar to human Stn1" /db_xref="GeneID:851655" /db_xref="SGD:S000002489" ORIGIN 1 mdkyghiahq egdvcyyipr lfkynsyysg tedvrifvgd lkyrmrvslq icekyydrrl 61 smlfwknhpl qqihligcii glqfkwigkq eyiffqlddc tsdsslvgyt sdmrfltckv 121 kkdsilswgl nitdligltl hvygqaslny qelqveylrl cyslteeidh wkitmnmreq 181 ldtpwslsdf vigelftqeq ewtpetsqie vvnpdfvgig yktpeskrne ttfieqlqee 241 rlkdeleiis pynstdtsns vhslsfrfvs slkdfpethf lnsgdqidng ndeqlkkley 301 qsanlpvmip nrtsaksnlm lillglqmke isnsdlyklk evrsvvtsla sflfqqqnvg 361 vmksfdslek eafrdlvnrl vsqgliglkd ktsetfdllp lknlfeyaek risvlmklqc 421 ytgtvqlshv qeklhlpyit tngivdvfke clkrtkkqyp evlknwwidl dpkngmedqn 481 sgillhleya aays // LOCUS NP_010368 392 aa linear PLN 30-JUN-2025 DEFINITION 25S rRNA (adenine645-N1)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010368 VERSION NP_010368.5 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180391.3 REFERENCE 1 (residues 1 to 392) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 392) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 392) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 392) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11930. On Jul 30, 2012 this sequence version replaced NP_010368.4. Method: conceptual translation. FEATURES Location/Qualifiers source 1..392 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..392 /product="25S rRNA (adenine645-N1)-methyltransferase" /EC_number="2.1.1.287" /calculated_mol_wt="45854" Region 117..392 /region_name="AdoMet_MTases" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl17173" /db_xref="CDD:473071" CDS 1..392 /gene="RRP8" /locus_tag="YDR083W" /coded_by="NM_001180391.3:1..1179" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:23180764|PMID:10864042]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:10864042]" /experiment="EXISTENCE:genetic interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:23180764]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:10864042]" /experiment="EXISTENCE:mutant phenotype:GO:0016433 rRNA (adenine) methyltransferase activity [PMID:23180764]" /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:23180764]" /note="Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase; methylates adenine (m1A) of large subunit (LSU) rRNA at position 645; involved in pre-rRNA cleavage at site A2; mutation is synthetically lethal with gar1 mutation; deletion disrupts telomere maintenance by influencing expression of neighboring gene STN1; mammalian homolog nucleomethylin has been linked to nutrient availability signaling pathways and obesity" /db_xref="GeneID:851656" /db_xref="SGD:S000002490" ORIGIN 1 malfnvegws iktktvafdn ktnksskdkk knnrkngklt reqklkeete aelkeqvedi 61 psegsvakdi pkknqeksdq netskkrkhd eeaplmqvke niekptkkql tplqqkmmak 121 ltgsrfrwin eqlytissde alklikeqpq lfdeyhdgfr sqvqawpenp vdvfvdqiry 181 rcmkpvnapg glpglkdske iviadmgcge aqlaleinnf fknynkkakk ylkrrhkvhs 241 fdlkkaneri tvadirnvpl pdesctivvf clalmgtnfl dfikeayril aprgelwiae 301 iksrfsdgkg nefvdalklm gffhkktfde nkmftrfeff kppaeiieer rqklerrqkf 361 ievetekeel ekkrrkiaeg kwllkpciyk rr // LOCUS NP_010369 199 aa linear PLN 30-JUN-2025 DEFINITION Tvp23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010369 VERSION NP_010369.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180392.3 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11931. On Jul 30, 2012 this sequence version replaced NP_010369.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..199 /product="Tvp23p" /calculated_mol_wt="23017" Region 15..156 /region_name="DUF846" /note="Eukaryotic protein of unknown function (DUF846); pfam05832" /db_xref="CDD:461754" CDS 1..199 /gene="TVP23" /locus_tag="YDR084C" /coded_by="NM_001180392.3:1..600" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17178117]" /note="Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" /db_xref="GeneID:851657" /db_xref="SGD:S000002491" ORIGIN 1 mdqarnfynt ilksshplll sfhlagkavp ivfyiigsmf lnftpqfitv vlllsfdfyl 61 tknitgrklv qlrwwydstd vnkdsnftfe sykqyapgpp inaidsklfw wsmyvtpviw 121 gvfavlcllr lkifylilvi vamcltawnt ygfrccdrwe pnsgqsdgqd tnnwfalpsv 181 pgfenlsrla niqsffqrq // LOCUS NP_010370 620 aa linear PLN 30-JUN-2025 DEFINITION Afr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010370 VERSION NP_010370.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180393.1 REFERENCE 1 (residues 1 to 620) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 620) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 620) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 620) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11932. Method: conceptual translation. FEATURES Location/Qualifiers source 1..620 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..620 /product="Afr1p" /calculated_mol_wt="71233" CDS 1..620 /gene="AFR1" /locus_tag="YDR085C" /coded_by="NM_001180393.1:1..1863" /experiment="EXISTENCE:direct assay:GO:0001400 mating projection base [PMID:7823940]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:18552279|PMID:8413281]" /experiment="EXISTENCE:mutant phenotype:GO:0007618 mating [PMID:18552279]" /experiment="EXISTENCE:mutant phenotype:GO:0032185 septin cytoskeleton organization [PMID:18552279]" /experiment="EXISTENCE:mutant phenotype:GO:0097271 protein localization to bud neck [PMID:18552279]" /note="Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; also detected in peroxisomes; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication" /db_xref="GeneID:851658" /db_xref="SGD:S000002492" ORIGIN 1 megsylsaqe nqpiperlip rsnstsnlfa lsstfsklnv rndadynysn pnkkrhiysg 61 eidcrsvtaa rkfpvrscsm taaqqrkrta lftvrernsy hegfnndqdy vsqyqkpqyt 121 fgvykeltpy qlqrskmkrs fqfpngeiyk pkldgkcths lkkpelnsrd sslfkfsekk 181 grnlskdfvg phngtsvihi ppndtgygvn slelntsvps tikssvssts pisavntlts 241 lpesqtdddd gyenktvtis ycfentvnek hgshiekldl stkektkptt nsglfdrkkk 301 tilgtekyrc iksqsklklg svlkklwrts gnsntkhgkk dtkrrripid dmvthsdgns 361 eaendielmd anldgiefdd detlmdtdsi fddllskend kydlrrrqle irqklhetsh 421 nddgkvsfrd tekhnvnegl idktiieefs klgeyiidtr nqppprsskr pslddnesar 481 yfynistdlr qslsgpislp mhvgndmvnr lrndweyirf edrrnslpds sfdkvetppk 541 pikkdvrfak evclastwss nayeranpef imnrhrllwm mkvhpsmnsa mneiklelns 601 ykknemvvhe nskcfthyli // LOCUS NP_010371 80 aa linear PLN 30-JUN-2025 DEFINITION translocon subunit SSS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010371 VERSION NP_010371.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180394.1 REFERENCE 1 (residues 1 to 80) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 80) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 80) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 80) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11933. Method: conceptual translation. FEATURES Location/Qualifiers source 1..80 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..80 /product="translocon subunit SSS1" /calculated_mol_wt="8812" Region 20..80 /region_name="secE_euk_arch" /note="protein translocase SEC61 complex gamma subunit, archaeal and eukaryotic; TIGR00327" /db_xref="CDD:273016" CDS 1..80 /gene="SSS1" /locus_tag="YDR086C" /coded_by="NM_001180394.1:1..243" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005784 Sec61 translocon complex [PMID:8612571|PMID:7758110]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9252322]" /experiment="EXISTENCE:direct assay:GO:0015450 protein-transporting ATPase activity [PMID:7758110]" /experiment="EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7758110]" /experiment="EXISTENCE:direct assay:GO:0071261 Ssh1 translocon complex [PMID:8612571]" /experiment="EXISTENCE:genetic interaction:GO:0005198 structural molecule activity [PMID:7961662]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:7961662]" /experiment="EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:12860997]" /note="Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p); this complex forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p" /db_xref="GeneID:851659" /db_xref="SGD:S000002493" ORIGIN 1 marasekgee kkqsnnqvek lveapvefvr egtqflakck kpdlkeytki vkavgigfia 61 vgiigyaikl ihipiryviv // LOCUS NP_010372 278 aa linear PLN 30-JUN-2025 DEFINITION Rrp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010372 VERSION NP_010372.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180395.3 REFERENCE 1 (residues 1 to 278) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 278) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 278) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 278) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11934. On Jul 30, 2012 this sequence version replaced NP_010372.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..278 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..278 /product="Rrp1p" /calculated_mol_wt="33071" Region 6..243 /region_name="Nop52" /note="Nucleolar protein,Nop52; pfam05997" /db_xref="CDD:461800" CDS 1..278 /gene="RRP1" /locus_tag="YDR087C" /coded_by="NM_001180395.3:1..837" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:3549696]" /note="Essential evolutionarily conserved nucleolar protein; necessary for biogenesis of 60S ribosomal subunits and for processing of pre-rRNAs to mature rRNA; associated with several distinct 66S pre-ribosomal particles" /db_xref="GeneID:851660" /db_xref="SGD:S000002494" ORIGIN 1 metsnfvkql ssnnrktrvn alealkkylt akqfkenkqi efnklwkgly yamwfsdrpr 61 pqqrlanelg elhglyfdpk dnstadeltt ndkafikfsr gfwkvmcfew fnidryrldk 121 ylllirrvlf sqlkylqsrn wdkklvdeyi kkvlrwlpls gspkvytgip ihivdillde 181 werllkdgde ddedeenkee emrkiaesak ktpladviai fqdivadynn skvlrekike 241 dlfsdtrlvs wdilegetqh ndssneseee eeeewkgf // LOCUS NP_010373 382 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SLU7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010373 VERSION NP_010373.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180396.3 REFERENCE 1 (residues 1 to 382) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 382) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 382) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 382) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11935. On Jul 30, 2012 this sequence version replaced NP_010373.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..382 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..382 /product="mRNA splicing protein SLU7" /calculated_mol_wt="44506" Region 122..137 /region_name="zf-CCHC" /note="Zinc knuckle; pfam00098" /db_xref="CDD:395050" Region 166..>347 /region_name="Slu7" /note="Pre-mRNA splicing Prp18-interacting factor; pfam11708" /db_xref="CDD:463326" CDS 1..382 /gene="SLU7" /locus_tag="YDR088C" /gene_synonym="SLT17" /coded_by="NM_001180396.3:1..1149" /experiment="EXISTENCE:direct assay:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:12212850]" /experiment="EXISTENCE:direct assay:GO:0000386 second spliceosomal transesterification activity [PMID:12212850]" /experiment="EXISTENCE:direct assay:GO:0005681 spliceosomal complex [PMID:12212850]" /experiment="EXISTENCE:direct assay:GO:0071021 U2-type post-spliceosomal complex [PMID:12212850]" /note="RNA splicing factor; required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain" /db_xref="GeneID:851661" /db_xref="SGD:S000002495" ORIGIN 1 mnnnsrnnen rstinrnkrq lqqakeknen ihipryirnq pwyykdtpke qegkkpgndd 61 tstaeggeks dylvhhrqka kggaldidnn sepkigmgik defklirpqk msvrdshsls 121 fcrncgeagh kekdcmekpr kmqklvpdln sqknngtvlv ratdddwdsr kdrwygysgk 181 eyneliskwe rdkrnkikgk dksqtdetlw dtdeeielmk lelykdsvgs lkkddadnsq 241 lyrtstrlre dkaaylndin stesnydpks rlyktetlga vdekskmfrr hltgeglkln 301 elnqfarsha kemgirdeie dkekvqhvlv anptkyeylk kkreqeetkq pkivsigdle 361 arkvdgtkqs eeqrnhlkdl yg // LOCUS NP_010374 869 aa linear PLN 30-JUN-2025 DEFINITION Vtc5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010374 VERSION NP_010374.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180397.1 REFERENCE 1 (residues 1 to 869) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 869) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 869) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 869) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11936. Method: conceptual translation. FEATURES Location/Qualifiers source 1..869 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..869 /product="Vtc5p" /calculated_mol_wt="98581" Region 2..142 /region_name="SPX_YDR089W" /note="SPX domain of the yeast protein YDR089W and related proteins; cd14474" /db_xref="CDD:269895" CDS 1..869 /gene="VTC5" /locus_tag="YDR089W" /coded_by="NM_001180397.1:1..2610" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922|PMID:27587415]" /experiment="EXISTENCE:mutant phenotype:GO:0006799 polyphosphate biosynthetic process [PMID:27587415]" /experiment="EXISTENCE:mutant phenotype:GO:0030643 intracellular phosphate ion homeostasis [PMID:27587415]" /experiment="EXISTENCE:physical interaction:GO:0033254 vacuolar transporter chaperone complex [PMID:27587415]" /note="Novel subunit of the vacuolar transporter chaperone complex; vacuolar transmembrane protein that regulates biosynthesis of polyphosphate; deletion reduces and overexpression increases polyP accumulation; SPX domain (Syg1, Pho81, Xpr1)-containing protein involved in phosphate homeostasis; relocalizes from vacuole to cytoplasm upon DNA replication stress" /db_xref="GeneID:851663" /db_xref="SGD:S000002496" ORIGIN 1 mkfedrilnk sipewkfyni nyeklkvaik kvtaydydnp ndsgmeklln qcsvafdqef 61 qnvnlfvslk ikeistrils vessiidfsk glnktsrnrf nlrklkiina hvddcnfelq 121 llsrfliiqr ialrklfkkl lnefpqdsen pltaseyvts irnseslrng hegisfmkld 181 ldpyllevsl ivdvlhdlen kledatepav eqrslnrsde sahtssspea nnsslpaspr 241 sipllsnkkt skmidsslef dtalidkaen lgrfllssed ieglkfmlln igfriiddsi 301 istskeildt tdninsagnk sirsaksfnd lqhtlslskq knilpsavqs nekyvsisil 361 dtvgnegspl lltddninqh pnmivsstae dtcivmchvg glrnhvvtnd lllrdvknil 421 samrsgndtk nisalinsld pspiskiale wiqshrlkti epkldfkrtr fisadngdiy 481 lialdesiti gnvstlpfpi leikklsrss glsqtained nkfkqlmksv vtnefqcsli 541 ppdlttwkic lelvhsnelq ndlfqlllrd qyklnsddsl spdeffqlgk drleeefdlt 601 gpinnsqgsv dsgrrvrihk kskqsdnetk kkpirywnef deqeednldn afyidtngsr 661 sttdneesll lrnsppdygf ilfsrnfinr tydfceklrn lirhdkktsp dlfqnskhph 721 csstnygsva sfgsqstsas yddvqrylqy qqqdiedsqs iyeyrhdevv tflylsallt 781 scimasvclg ivlslfrgqs nneidleiqn iliaiiiisl lvslilicac llllfsrftl 841 apiwhyvgcf tmffsvtgtv cygmieiff // LOCUS NP_010375 310 aa linear PLN 30-JUN-2025 DEFINITION Ilt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010375 VERSION NP_010375.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180398.1 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11937. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..310 /product="Ilt1p" /calculated_mol_wt="34500" Region 16..66 /region_name="PQ-loop" /note="PQ loop repeat; pfam04193" /db_xref="CDD:461220" CDS 1..310 /gene="ILT1" /locus_tag="YDR090C" /coded_by="NM_001180398.1:1..933" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:30045857]" /note="hypothetical protein; deletion confers sensitivity to cationic compounds; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane" /db_xref="GeneID:851664" /db_xref="SGD:S000002497" ORIGIN 1 misekaatal atiatvcwcv qlipqiiynw kkkdctglpp lmmflwvvsg ipfaiyfcvs 61 kgnvilqvqp hlfmffcsis fvqscyyppi smarskivmi vaaiiaadvg mevgfilwlr 121 plyekgvkwp dlifgisasv llavgllppy felakrkgrv iginfaflfi dslgawlsii 181 svilgnmdim giilysivag melgifashf iwwcrfrfla kgntfdeesg qaqkeepdek 241 ieqdisksdr nvtnynldnc sipddassfa ddfniydstd ggtlsraqtl havhgvvvrt 301 dpdrysrlsv // LOCUS NP_010376 608 aa linear PLN 30-JUN-2025 DEFINITION Fe-S cluster-binding ribosome biosynthesis protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010376 VERSION NP_010376.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180399.3 REFERENCE 1 (residues 1 to 608) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 608) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 608) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 608) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11938. On Jul 30, 2012 this sequence version replaced NP_010376.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..608 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..608 /product="Fe-S cluster-binding ribosome biosynthesis protein" /calculated_mol_wt="68210" Region 7..604 /region_name="Rli1" /note="Translation initiation factor RLI1, contains Fe-S and AAA+ ATPase domains [Translation, ribosomal structure and biogenesis]; COG1245" /db_xref="CDD:440858" CDS 1..608 /gene="RLI1" /locus_tag="YDR091C" /coded_by="NM_001180399.3:1..1827" /experiment="EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:15660134]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15277527]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15277527|PMID:15660134|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:24424461]" /experiment="EXISTENCE:genetic interaction:GO:0006415 translational termination [PMID:20062004]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:15660134|PMID:22855532]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:15277527|PMID:15660134]" /experiment="EXISTENCE:mutant phenotype:GO:0032790 ribosome disassembly [PMID:22770215]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:15277527]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:24424461]" /experiment="EXISTENCE:physical interaction:GO:0006415 translational termination [PMID:20062004]" /note="Essential Fe-S protein; required for ribosome biogenesis, translation initiation/termination; facilitates binding of multifactor complex (MFC) of initiation factors to small ribosomal subunit; Dom34-Hbs1 complex and Rli1p work in dissociating inactive ribosomes, thereby facilitating translation restart; forms complex with Lto1p and Yae1p; dependency on ROS-labile FeS clusters, activity in nuclear ribosomal-subunit export impaired by mild oxidative stress" /db_xref="GeneID:851665" /db_xref="SGD:S000002498" ORIGIN 1 msdknsriai vsadkckpkk crqeckrscp vvktgklcie vtptskiafi seilcigcgi 61 cvkkcpfdai qiinlptnle ahvthrysan sfklhrlptp rpgqvlglvg tngigkstal 121 kilagkqkpn lgrfddppew qeiikyfrgs elqnyftkml eddikaiikp qyvdniprai 181 kgpvqkvgel lklrmekspe dvkryikilq lenvlkrdie klsggelqrf aigmscvqea 241 dvymfdepss yldvkqrlna aqiirsllap tkyvicvehd lsvldylsdf vciiygvpsv 301 ygvvtlpasv reginifldg hipaenlrfr tealqfriad atedlqndsa srafsypslk 361 ktqgdfvlnv eegefsdsei lvmmgengtg kttlikllag alkpdegqdi pklnvsmkpq 421 kiapkfpgtv rqlffkkirg qflnpqfqtd vvkplriddi idqevqhlsg gelqrvaivl 481 algipadiyl idepsaylds eqriicskvi rrfilhnkkt afivehdfim atyladkviv 541 fegipsknah arapeslltg cnrflknlnv tfrrdpnsfr prinkldsqm dkeqkssgny 601 ffldntgi // LOCUS NP_010377 153 aa linear PLN 30-JUN-2025 DEFINITION E2 ubiquitin-conjugating protein UBC13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010377 VERSION NP_010377.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180400.3 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11939. On Jul 30, 2012 this sequence version replaced NP_010377.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..153 /product="E2 ubiquitin-conjugating protein UBC13" /EC_number="2.3.2.23" /calculated_mol_wt="17337" Region 4..147 /region_name="UBCc_UBE2N" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 N and related proteins; cd23813" /db_xref="CDD:467433" CDS 1..153 /gene="UBC13" /locus_tag="YDR092W" /coded_by="NM_001180400.3:1..462" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:10089880]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:32265276]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:10089880]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10880451]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10880451]" /experiment="EXISTENCE:direct assay:GO:0010994 free ubiquitin chain polymerization [PMID:19706603]" /experiment="EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:10089880]" /experiment="EXISTENCE:mutant phenotype:GO:0006301 postreplication repair [PMID:10089880]" /experiment="EXISTENCE:mutant phenotype:GO:0044395 protein targeting to vacuolar membrane [PMID:32265276]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]" /experiment="EXISTENCE:physical interaction:GO:0031371 ubiquitin conjugating enzyme complex [PMID:10089880]" /note="E2 ubiquitin-conjugating enzyme; involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus" /db_xref="GeneID:851666" /db_xref="SGD:S000002499" ORIGIN 1 maslpkriik eteklvsdpv pgitaephdd nlryfqvtie gpeqspyedg ifelelylpd 61 dypmeapkvr fltkiyhpni drlgricldv lktnwspalq irtvllsiqa llaspnpndp 121 landvaedwi kneqgakaka rewtklyakk kpe // LOCUS NP_010378 1612 aa linear PLN 30-JUN-2025 DEFINITION aminophospholipid-translocating P4-type ATPase DNF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010378 VERSION NP_010378.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180401.1 REFERENCE 1 (residues 1 to 1612) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1612) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1612) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1612) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11940. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1612 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1612 /product="aminophospholipid-translocating P4-type ATPase DNF2" /EC_number="7.6.2.1" /calculated_mol_wt="182488" Region 229..1456 /region_name="ATPase-Plipid" /note="phospholipid-translocating P-type ATPase, flippase; TIGR01652" /db_xref="CDD:273734" Site order(712..714,887,916..918,985,1032..1034,1147,1150,1153, 1173,1176) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:319770" CDS 1..1612 /gene="DNF2" /locus_tag="YDR093W" /coded_by="NM_001180401.1:1..4839" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:33060204|PMID:12631737|PMID:12221123]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0070867 mating projection tip membrane [PMID:25378585]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:12631737]" /experiment="EXISTENCE:genetic interaction:GO:0007163 establishment or maintenance of cell polarity [PMID:15461661]" /experiment="EXISTENCE:genetic interaction:GO:0015247 aminophospholipid flippase activity [PMID:17015438|PMID:12631737]" /experiment="EXISTENCE:genetic interaction:GO:0045332 phospholipid translocation [PMID:17015438|PMID:12631737]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:12631737]" /experiment="EXISTENCE:mutant phenotype:GO:0015247 aminophospholipid flippase activity [PMID:12631737|PMID:17015438]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:12631737|PMID:17015438]" /experiment="EXISTENCE:mutant phenotype:GO:0099040 ceramide translocation [PMID:33060204]" /experiment="EXISTENCE:mutant phenotype:GO:0140346 phosphatidylserine flippase activity [PMID:12631737]" /experiment="EXISTENCE:mutant phenotype:GO:0140351 glycosylceramide flippase activity [PMID:33060204]" /note="Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF2 has a paralog, DNF1, that arose from the whole genome duplication" /db_xref="GeneID:851667" /db_xref="SGD:S000002500" ORIGIN 1 msspskptsp fvddiehesg sasnglssms pfddsfqfek pssahgniev aktggsvlkr 61 qskpmkdist pdlskvtfdg iddysndndi ndddelngkk teihehenev dddlhsfqat 121 pmpntggfed veldnnegsn ndsqadhklk rvrfgtrrnk sgridinrsk tlkwakknfh 181 naidefstke dslensalqn rsdelrtvyy nlplpedmld edglplavyp rnkirttkyt 241 pltffpknil fqfhnfaniy flillilgaf qifgvtnpgf asvplivivi itaikdgied 301 srrtvldlev nntrthilsg vknenvavdn vslwrrfkka ntralikife yfsenltaag 361 rekklqkkre elrrkrnsrs fgprgsldsi gsyrmsadfg rpsldyenln qtmsqanryn 421 dgenlvdrtl qpnpecrfak dywknvkvgd ivrvhnndei padmillsts dvdgacyvet 481 knldgetnlk vrqslkcski ikssrditrt kfwvesegph anlysyqgnf kwqdtqngni 541 rnepvninnl llrgctlrnt kwamgmvift gddtkimina gvtptkksri srelnfsvil 601 nfvllfilcf tagivngvyy kqkprsrdyf efgtiggsas tngfvsfwva vilyqslvpi 661 slyisveiik taqaifiytd vllynakldy pctpkswnis ddlgqieyif sdktgtltqn 721 vmefkkctin gvsygrayte alaglrkrqg vdvesegrre keeiakdret midelrsmsd 781 ntqfcpedlt fvskeivedl kgssgdhqqk ccehfllala lchsvlvepn kddpkkldik 841 aqspdesalv starqlgysf vgssksgliv eiqgvqkefq vlnvlefnss rkrmsciiki 901 pgstpkdepk allickgads viysrldrtq ndatllekta lhleeyateg lrtlclaqre 961 ltwseyerwv ktydvaaasv tnreeeldkv tdvierelil lggtaiedrl qdgvpdsial 1021 laeagiklwv ltgdkvetai nigfscnvln ndmellvvka sgedveefgs dpiqvvnnlv 1081 tkylrekfgm sgseeelkea krehglpqgn faviidgdal kvalngeemr rkflllcknc 1141 kavlccrvsp aqkaavvklv kktldvmtla igdgsndvam iqsadvgvgi ageegrqavm 1201 csdyaigqfr yvtrlvlvhg kwcykrlaem ipqffyknvi ftlslfwygi ynnfdgsylf 1261 eytyltfynl aftsvpvill avldqdvsdt vsmlvpqlyr vgilrkewnq tkflwymldg 1321 vyqsvicfff pylayhknmv vtenglgldh ryfvgvfvta iavtscnfyv fmeqyrwdwf 1381 cglficlsla vfygwtgiwt sssssnefyk gaarvfaqpa ywavlfvgvl fcllprftid 1441 cirkifypkd ieivremwlr gdfdlypqgy dptdpsrpri neirpltdfk episldthfd 1501 gvshsqetiv teeipmsiln geqgsrkgyr vsttlerrdq lspvtttnnl prrsmasarg 1561 nklrtsldrt reemlanhql dtrysverar asldlpginh aetllsqrsr dr // LOCUS NP_010381 894 aa linear PLN 30-JUN-2025 DEFINITION histone demethylase GIS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010381 VERSION NP_010381.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180404.1 REFERENCE 1 (residues 1 to 894) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 894) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 894) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 894) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11941. Method: conceptual translation. FEATURES Location/Qualifiers source 1..894 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..894 /product="histone demethylase GIS1" /calculated_mol_wt="99350" Region 11..52 /region_name="JmjN" /note="Small domain found in the jumonji family of transcription factors; smart00545" /db_xref="CDD:128818" Region 191..307 /region_name="JmjC" /note="JmjC domain, hydroxylase; pfam02373" /db_xref="CDD:396791" Region <828..879 /region_name="PHA00733" /note="hypothetical protein" /db_xref="CDD:177301" Region 828..851 /region_name="zf-C2H2_4" /note="C2H2-type zinc finger; pfam13894" /db_xref="CDD:464025" Region 830..851 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 859..876 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..894 /gene="GIS1" /locus_tag="YDR096W" /coded_by="NM_001180404.1:1..2685" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12799368]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:12799368]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:24390141|PMID:15661010|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10835355]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10523651]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:12799368]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10835355]" /experiment="EXISTENCE:mutant phenotype:GO:0051864 histone H3K36 demethylase activity [PMID:17369256]" /experiment="EXISTENCE:mutant phenotype:GO:0071071 regulation of phospholipid biosynthetic process [PMID:12799368]" /note="Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication" /db_xref="GeneID:851670" /db_xref="SGD:S000002503" ORIGIN 1 meikpvevid gvpvfkpsmm efanfqyfid eitkfgieng ivkvippkew lellegsppa 61 eslktiqlds piqqqakrwd khengvfsie neydnksynl tqwknlaesl dsrisqgdfn 121 dktlkencrv dsqqdcydla qlqilesdfw ktiafskpfy avdenssifp ydltlwnlnn 181 lpdsinssnr rlltgqskci fpwhldeqnk csinylhfga pkqwysipsa ntdqflkils 241 kepssnkenc pafirhqnii tspdflrknn ikfnrvvqfq hefiitfpyc mysgfnygyn 301 fgesiefild qqavvrkqpl kcgcgnkkee rksgpfsnls ydsneseqrg sitdndndlf 361 qkvrsfdell nhssqelqnl ednknplfsn inmnrpqsss lrsttpngvn qflnmnqtti 421 srisspllsr mmdlsnivep tlddpgskfk rkvltpqlpq mnipsnssnf gtpsltntns 481 llsnitatst npstttngsq nhnnvnangi ntsaaasinn nisstnnsan nsssnnnvst 541 vpssmmhsst lngtsglggd nddnmlalsl atlansatas prltlpplss pmnpnghtsy 601 ngnmmnnnsg ngsngsnsys ngvttaaatt tsaphnlsiv spnptyspnp lslyltnskn 661 plnsglapls pstsnipflk rnnvvtlnis reaskspiss fvndyrsplg vsnplmysst 721 indysngtgi rqnsnninpl dagpsfsplh kkpkilngnd nsnldsnnfd ysftgnkqes 781 npsilnnntn nndnyrtssm nnngnnyqah sskfgenevi msdhgkiyic recnrqfssg 841 hhltrhkksv hsgekphscp rcgkrfkrrd hvlqhlnkki pctqementk laes // LOCUS NP_010382 1242 aa linear PLN 30-JUN-2025 DEFINITION mismatch repair ATPase MSH6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010382 VERSION NP_010382.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180405.3 REFERENCE 1 (residues 1 to 1242) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1242) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1242) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1242) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11942. On Jul 30, 2012 this sequence version replaced NP_010382.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1242 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1242 /product="mismatch repair ATPase MSH6" /calculated_mol_wt="139950" Region 71..>282 /region_name="PRK08581" /note="amidase domain-containing protein" /db_xref="CDD:236304" Region 310..1177 /region_name="MutS" /note="DNA mismatch repair ATPase MutS [Replication, recombination and repair]; COG0249" /db_xref="CDD:440019" CDS 1..1242 /gene="MSH6" /locus_tag="YDR097C" /gene_synonym="PMS3; PMS6" /coded_by="NM_001180405.3:1..3729" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:10066781]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:9545323]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006298 mismatch repair [PMID:11237611]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9819445]" /experiment="EXISTENCE:direct assay:GO:0032137 guanine/thymine mispair binding [PMID:8816473]" /experiment="EXISTENCE:direct assay:GO:0032138 single base insertion or deletion binding [PMID:8816473]" /experiment="EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:16702432]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:2685551|PMID:9520271]" /experiment="EXISTENCE:mutant phenotype:GO:0032138 single base insertion or deletion binding [PMID:10347163]" /experiment="EXISTENCE:mutant phenotype:GO:0043111 replication fork arrest [PMID:27045900]" /experiment="EXISTENCE:physical interaction:GO:0032301 MutSalpha complex [PMID:8816473]" /note="Protein required for mismatch repair in mitosis and meiosis; forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; also involved in interstrand cross-link repair; potentially phosphorylated by Cdc28p; contains PIP motif that binds PCNA (Pol30p) and Rev1p" /db_xref="GeneID:851671" /db_xref="SGD:S000002504" ORIGIN 1 mapatpktsk tahfengsts sqkkmkqssl lsffskqvps gtpskkvqkp tpatlentat 61 dkitknpqgg ktgklfvdvd edndltiaee tvstvrsdim hsqepqsdtm lnsnttepks 121 tttdedlsss qsrrnhkrrv nyaesdddds dttftakrkk gkvvdsesde deylpdkndg 181 dedddiaddk edikgelaed sgddddlisl aettskkkfs yntshssspf trnisrdnsk 241 kksrpnqaps rsynpshsqp satsksskfn kqneeryqwl vderdaqrrp ksdpeydprt 301 lyipssawnk ftpfekqywe ikskmwdciv ffkkgkffel yekdallana lfdlkiaggg 361 ranmqlagip emsfeywaaq fiqmgykvak vdqresmlak emregskgiv krelqcilts 421 gtltdgdmlh sdlatfclai reepgnfyne tqldsstivq klntkifgaa fidtatgelq 481 mlefeddsec tkldtlmsqv rpmevvmern nlstlankiv kfnsapnaif nevkageefy 541 dcdktyaeii sseyfsteed wpevlksyyd tgkkvgfsaf ggllyylkwl kldknlismk 601 nikeydfvks qhsmvldgit lqnleifsns fdgsdkgtlf klfnraitpm gkrmmkkwlm 661 hpllrkndie srldsvdsll qditlreqle itfsklpdle rmlarihsrt ikvkdfekvi 721 tafetiielq dslknndlkg dvskyissfp eglveavksw tnaferqkai neniivpqrg 781 fdiefdksmd riqeledelm eilmtyrkqf kcsniqykds gkeiytieip isatknvpsn 841 wvqmaankty kryysdevra larsmaeake ihktleedlk nrlcqkfdah yntiwmptiq 901 aisnidclla itrtseylga pscrptivde vdsktntqln gflkfkslrh pcfnlgatta 961 kdfipndiel gkeqprlgll tganaagkst ilrmaciavi maqmgcyvpc esavltpidr 1021 imtrlgandn imqgkstffv elaetkkild matnrsllvv delgrggsss dgfaiaesvl 1081 hhvathiqsl gffathygtl assfkhhpqv rplkmsilvd eatrnvtfly kmlegqsegs 1141 fgmhvasmcg iskeiidnaq iaadnlehts rlvkerdlaa nnlngevvsv pgglqsdfvr 1201 iaygdglknt klgsgegvln ydwnikrnvl kslfsiiddl qs // LOCUS NP_010383 250 aa linear PLN 30-JUN-2025 DEFINITION monothiol glutaredoxin GRX3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010383 VERSION NP_010383.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180406.4 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11943. On Feb 18, 2015 this sequence version replaced NP_010383.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..250 /product="monothiol glutaredoxin GRX3" /calculated_mol_wt="28130" Region 9..106 /region_name="TRX_PICOT" /note="TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an...; cd02984" /db_xref="CDD:239282" Region 154..238 /region_name="GRX_PICOT_like" /note="Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; cd03028" /db_xref="CDD:239326" Site order(168,176..178,216..217) /site_type="other" /note="putative GSH binding site [chemical binding]" /db_xref="CDD:239326" Site order(176,179) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239326" CDS 1..250 /gene="GRX3" /locus_tag="YDR098C" /coded_by="NM_001180406.4:1..753" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15456753]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18281282]" /experiment="EXISTENCE:direct assay:GO:0051536 iron-sulfur cluster binding [PMID:31493153]" /experiment="EXISTENCE:genetic interaction:GO:0006879 intracellular iron ion homeostasis [PMID:17074835]" /experiment="EXISTENCE:mutant phenotype:GO:0015036 disulfide oxidoreductase activity [PMID:10567543|PMID:27085841]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:20889785]" /experiment="EXISTENCE:mutant phenotype:GO:2000678 negative regulation of transcription regulatory region DNA binding [PMID:23045394]" /experiment="EXISTENCE:physical interaction:GO:0006879 intracellular iron ion homeostasis [PMID:17074835]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:23045394]" /note="Glutathione-dependent oxidoreductase; hydroperoxide and superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx4p and Grx5p; redundantly protects cells from oxidative damage along with GRX4 and GRX5; with Grx4p, promotes the dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx4p in the deglutathionylation of Sir2p, restoring deacetylase activity after disulfide stress" /db_xref="GeneID:851672" /db_xref="SGD:S000002505" ORIGIN 1 mpvieindqe qftyltttaa gdklivlyfh tswaepckal kqvfeaisne psnsnvsfls 61 idadenseis elfeisavpy fiiihkgtil kelsgadpke yvslledckn svnsgssqth 121 tmenanvneg shndedddde eeeeeteeqi narltklvna apvmlfmkgs psepkcgfsr 181 qlvgilrehq vrfgffdilr desvrqnlkk fsewptfpql yingefqggl diikesleed 241 pdflqhalqs // LOCUS NP_058140 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058140 VERSION NP_058140.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184417.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11944. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198465" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1265..>1453 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YDR098C-B" /coded_by="join(NM_001184417.2:1..1305, NM_001184417.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:851674" /db_xref="SGD:S000007391" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npginvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp nsapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmntwdtd kyydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlgeg dneiqydilg leikyqrsky mklgmekslt eklpklnvpl 1501 npkgkklrap gqpghyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkptk pdnklvaisd asygnqpyyk 1621 sqigniflln gkviggkstk asltctstte aeihavseai pllnnlshlv qelnkkpiik 1681 gsltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_058141 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058141 VERSION NP_058141.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184416.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11945. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..440 /product="gag protein" /calculated_mol_wt="48926" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YDR098C-A" /coded_by="NM_001184416.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:851675" /db_xref="SGD:S000007390" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_010384 273 aa linear PLN 30-JUN-2025 DEFINITION 14-3-3 family protein BMH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010384 VERSION NP_010384.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180407.3 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11946. On Jul 30, 2012 this sequence version replaced NP_010384.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..273 /product="14-3-3 family protein BMH2" /calculated_mol_wt="30930" Region 1..273 /region_name="BMH1" /note="14-3-3 family protein [Signal transduction mechanisms]; COG5040" /db_xref="CDD:227373" CDS 1..273 /gene="BMH2" /locus_tag="YDR099W" /gene_synonym="SCD3" /coded_by="NM_001180407.3:1..822" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:12167636]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25409301|PMID:22842922|PMID:12167636]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:25409301]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:genetic interaction:GO:0001402 signal transduction involved in filamentous growth [PMID:9215628]" /experiment="EXISTENCE:genetic interaction:GO:0006031 chitin biosynthetic process [PMID:17559233]" /experiment="EXISTENCE:genetic interaction:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:19934224]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:19934224]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:9215628]" /experiment="EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:9215628]" /experiment="EXISTENCE:genetic interaction:GO:0030437 ascospore formation [PMID:9215628]" /experiment="EXISTENCE:genetic interaction:GO:0070873 regulation of glycogen metabolic process [PMID:9215628]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:14704161]" /experiment="EXISTENCE:mutant phenotype:GO:0043066 negative regulation of apoptotic process [PMID:22785534]" /experiment="EXISTENCE:mutant phenotype:GO:0050815 phosphoserine residue binding [PMID:9822578]" /experiment="EXISTENCE:physical interaction:GO:0000278 mitotic cell cycle [PMID:17030612]" /experiment="EXISTENCE:physical interaction:GO:0031397 negative regulation of protein ubiquitination [PMID:17030612]" /note="14-3-3 protein, minor isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates multiple processes including exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; abundance relative to Bmh1p increases during sporulation; similar to several human 14-3-3 proteins" /db_xref="GeneID:851676" /db_xref="SGD:S000002506" ORIGIN 1 msqtredsvy laklaeqaer yeemvenmka vassgqelsv eernllsvay knvigarras 61 wrivssieqk eeskeksehq velirsyrsk ieteltkisd dilsvldshl ipsattgesk 121 vfyykmkgdy hrylaefssg darekatnss leayktasei attelppthp irlglalnfs 181 vfyyeiqnsp dkachlakqa fddaiaeldt lseesykdst limqllrdnl tlwtsdises 241 gqedqqqqqq qqqqqqqqqq qapaeqtqge ptk // LOCUS NP_010385 143 aa linear PLN 30-JUN-2025 DEFINITION Tvp15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010385 VERSION NP_010385.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180408.3 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11947. On Jul 30, 2012 this sequence version replaced NP_010385.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..143 /product="Tvp15p" /calculated_mol_wt="15750" Region 6..132 /region_name="COPI_assoc" /note="COPI associated protein; pfam08507" /db_xref="CDD:400693" CDS 1..143 /gene="TVP15" /locus_tag="YDR100W" /coded_by="NM_001180408.3:1..432" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]" /experiment="EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17178117]" /note="Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p" /db_xref="GeneID:851677" /db_xref="SGD:S000002507" ORIGIN 1 msvippkffk ianisigcid iiaalsqlty iftnlnvfll avyglalsvp ivylefkvps 61 nlyryasfyf sflgrglsyi llsliisfgg iynilagmft filgvafivf hfsqfveepa 121 nfrapgssls igdddidddd dmi // LOCUS NP_010386 593 aa linear PLN 30-JUN-2025 DEFINITION putative hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010386 VERSION NP_010386.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180409.1 REFERENCE 1 (residues 1 to 593) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 593) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 593) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 593) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11948. Method: conceptual translation. FEATURES Location/Qualifiers source 1..593 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..593 /product="putative hydrolase" /calculated_mol_wt="65082" Region 25..>285 /region_name="APP_MetAP" /note="A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; cl00279" /db_xref="CDD:469704" CDS 1..593 /gene="ARX1" /locus_tag="YDR101C" /coded_by="NM_001180409.1:1..1782" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16648468]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:12374754|PMID:16648468]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16648468]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16648468|PMID:12374754]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:16648468]" /experiment="EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:18077551|PMID:17803941]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:16648468|PMID:18077551]" /note="Nuclear export factor for the ribosomal pre-60S subunit; shuttling factor which directly binds FG rich nucleoporins and facilities translocation through the nuclear pore complex; interacts directly with Alb1p; responsible for Tif6p recycling defects in the absence of Rei1; associated with the ribosomal export complex" /db_xref="GeneID:851678" /db_xref="SGD:S000002508" ORIGIN 1 malaishedt qillkdknil qesvlnkyrt agqiaqtalk yvtslindsy hskttqrqlt 61 vpelclltds filtrleqyy knkvnergia ipttididqi sggwcpeidd tqnllnwnkg 121 kdstfassvt gtlrpgdlvk itlgvhidgy tsevshtmvi ypvdetkpil qptgpllggk 181 adavaaahia metvvallac altpeklpas lggtssgitg qlirtivdti arsyncgvvp 241 gsrvrrirrf lagqnegiva ereykgvvwt eshqeadlls ntdakdltvv drgqstpftn 301 vsaipsddfv vqsgevylid lkmaslehct kkglvtletv dsytgkshka geliarpgay 361 vrdfaqthil klktsrqllt kidkqgvypf klshlssnfp fvheneeelq slkkdlksfr 421 lgmseisnny lcvespiqia rwvpwdhilk atnpngnlsy datstltlpg helplpklgv 481 saiklkslmn stkesislpv arecntivlc dssvsttdrp ellrltggsk tcqpswihsq 541 helnpqdsiv qgifqlatla kdkrfglllk etqpmkqksv etsnggveet mkm // LOCUS NP_001335756 110 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR102C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335756 VERSION NP_001335756.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348810.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80276. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..110 /product="uncharacterized protein" /calculated_mol_wt="12569" CDS 1..110 /locus_tag="YDR102C" /coded_by="NM_001348810.1:1..333" /note="hypothetical protein; conserved among S. cerevisiae strains; YDR102C is not an essential gene; homozygous diploid deletion strain exhibits high budding index" /db_xref="GeneID:851679" /db_xref="SGD:S000002509" ORIGIN 1 mtlllqkcir velrkdpifn asssleifls vlesviypfk gnlilldfhl vdvqttcyqr 61 nssmrnqlms vfcqslreft ltalscnsyc iiivatrwqk idnalkmtgr // LOCUS NP_010388 917 aa linear PLN 30-JUN-2025 DEFINITION Ste5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010388 VERSION NP_010388.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180411.1 REFERENCE 1 (residues 1 to 917) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 917) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 917) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 917) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 917) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 917) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 917) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 917) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 917) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11949. Method: conceptual translation. FEATURES Location/Qualifiers source 1..917 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..917 /product="Ste5p" /calculated_mol_wt="102597" Region 175..>207 /region_name="RING_Ubox" /note="RING finger (Really Interesting New Gene) domain and U-box domain superfamily; cl17238" /db_xref="CDD:473075" Region 287..316 /region_name="Ste5" /note="Scaffold protein Ste5, Fus3-binding region; pfam11610" /db_xref="CDD:402967" Region 594..775 /region_name="Ste5_C" /note="Protein kinase Fus3-binding; pfam12194" /db_xref="CDD:403425" CDS 1..917 /gene="STE5" /locus_tag="YDR103W" /gene_synonym="HMD3; NUL3" /coded_by="NM_001180411.1:1..2754" /experiment="EXISTENCE:direct assay:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8062390]" /experiment="EXISTENCE:direct assay:GO:0001934 positive regulation of protein phosphorylation [PMID:19303851]" /experiment="EXISTENCE:direct assay:GO:0005078 MAP-kinase scaffold activity [PMID:8062390]" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:16847350]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9732267]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11781566]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:17952059|PMID:11781566]" /experiment="EXISTENCE:direct assay:GO:0070867 mating projection tip membrane [PMID:9732267]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:15192700]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:16847350]" /experiment="EXISTENCE:mutant phenotype:GO:0043409 negative regulation of MAPK cascade [PMID:16424299]" /experiment="EXISTENCE:physical interaction:GO:0005078 MAP-kinase scaffold activity [PMID:7851759]" /experiment="EXISTENCE:physical interaction:GO:0031681 G-protein beta-subunit binding [PMID:7667635]" /note="Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation" /db_xref="GeneID:851680" /db_xref="SGD:S000002510" ORIGIN 1 mmetptdniv spfhnfgsst qysgtlsrtp nqiielekps tlsplsrgkk wteklarfqr 61 ssakkkrfsp spissstfsf spksrvtssn ssgnedgnlm ntpstvstdy lpqhphrtss 121 lprpnsnlfh asnsnlsran eppraenlsd nippkvapfg ypiqrtsikk sflnasctlc 181 depisnrrkg ekiielacgh lshqecliis fgttskadvr alfpfctkck kdtnkavqci 241 pendelkdil isdflihkip dselsitpqs rfppyspllp pfglsytpve rqtiysqaps 301 lnpnlilaap pkernqipqk ksnytflhsp lghrripsga nsiladtsva lsandsisav 361 snsvrakdde tkttlpllrs yfiqillnnf qeelqdwrid gdygllrlvd klmiskdgqr 421 yiqcwcflfe dafviaevdn dvdvleirlk nlevftpian lrmttleasv lkctlnkqhc 481 adlsdlyivq ninsdesttv qkwisgilnq dfvfnednit stlpilpiik nfskdvgngr 541 hetstflgli npnkvvevgn vhdndtviir rgftlnsgec srqstvdsiq svlttissil 601 slkrekpdnl aiilqidftk lkeedslivv ynslkaltik farlqfcfvd rnnyvldygs 661 vlhkidslds isnlksksss tqfspiwlkn tlypeniheh lgivavsnsn meakksilfq 721 dyrcftsfgr rrpnelkikv gylnvdysdk idelveassw tfvletlcys fglsfdehdd 781 ddeednddst dneldnssgs lsdaesttti hidspfdnen atanmvndrn lltegehsni 841 enletvassv qpalipnirf slhseeegtn enenendmpv lllsdmdkgi dgitrrssfs 901 sliesgnnnc plhmdyi // LOCUS NP_010389 1245 aa linear PLN 30-JUN-2025 DEFINITION Spo71p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010389 VERSION NP_010389.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180412.3 REFERENCE 1 (residues 1 to 1245) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1245) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1245) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1245) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11950. On Jul 30, 2012 this sequence version replaced NP_010389.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1245 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1245 /product="Spo71p" /calculated_mol_wt="145051" Region 32..94 /region_name="Spo7_2_N" /note="Sporulation protein family 7; pfam15407" /db_xref="CDD:434700" Region 1032..1228 /region_name="PH_4" /note="Pleckstrin homology domain; pfam15404" /db_xref="CDD:434699" CDS 1..1245 /gene="SPO71" /locus_tag="YDR104C" /coded_by="NM_001180412.3:1..3738" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24036347]" /experiment="EXISTENCE:direct assay:GO:1902657 protein localization to prospore membrane [PMID:24036347]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:22611022|PMID:26605945|PMID:27303688]" /note="Meiosis-specific protein required for prospore membrane morphogenesis; localizes to the prospore membrane (PSM) during sporulation; required for PSM elongation and closure; genetically antagonistic to SPO1; recruits Vps13p to the PSM during sporulation; interacts and functions cooperatively with Spo73p; mutants have defects in the PSM, aberrant spore wall formation and reduced PtdIns-phosphate pools in the PSM; contains three PH-like domains" /db_xref="GeneID:851681" /db_xref="SGD:S000002511" ORIGIN 1 mdsivnvved dvkyaqrvts fsspqnanvk vftiprhsft afrlsyvspt elsacsqvtl 61 lggipkqwya dqnnqvwkll tkislrkvrk qsdmlrrygy gtiykkrvgk iptalylrkh 121 ftwsyednts ihnghrlkea ememkrtrss pvqkseykls lprrcrsssd qnfmrqellk 181 ekkselsrnn slplidtaqa vdihpvlhee dqentnkrnk sllsnlkrkd lgesksisrk 241 dyshfdrips pssarsvget dfnynrepse dtlrypdsii evtnrtspap nsilsrsgqf 301 vnsndlsdgf stsntinnvg lnanekiffn alqsmekenl mlwktsqkyg tylderrksa 361 dafqkrergs cvdigklhss hlpfinilpp wptelteeer iihdrlaskh shhirkhvhn 421 arnktsckik dsvgtflgmt nsltnkatvk krtgqilkke kmlvmvkeai qnkvplpnfs 481 enecfdtrvs erwkeyivia rstgrfdppi llqfyrhrhi peiedissia tkyhrnpldf 541 flsrncivkf yssldktisi qkpdkrlggf idesiekkde lkhyspikif ilrcssirss 601 grwykflles ldrqlftpai nlkiplteis ikinlneiif qklidlgkqe kdrlkicflq 661 rgykifqhpi lryftvaile klklahydyl irkwdtenpv lgcalkrydr lewipcdeds 721 lvtgifafcq shliqyrpia nrlretksle gkclkeptpi egflirltdk ygsartnfgk 781 ysistayfft cenllfsmka yranpplpid smiddtstei ekeeiwkqwk kipevyeqqp 841 ypldtndhie wmncqttqse ydsrdfyafh cfhrridqil ktdnvidlte vkdiyqgtrt 901 dyeadkikyg vykeaseifw hrnyeiddvs rsvinietsn glllkllats atvaeewvik 961 lkqmisywkn kqredterll kirrsnagll mlngeeetki gentlrwive hgradeqtfn 1021 angislsrpl iqkgplyqkp hkhsvfskyy vvlisgfivl fhcfhrsttg fakevleyah 1081 yvtipiddcy lysgttteld llqrdrtfde inygshalpr vygdgwrsve dessrcftlw 1141 fgtrralssn rlqkkgnekq ytqdygrqdn nidppsapea dlnnsnvpsn tdkihftkkl 1201 gvsgksmvfm arsrqerdlw vmsiyyeler lrrtastsns rnqtm // LOCUS NP_010390 473 aa linear PLN 30-JUN-2025 DEFINITION Tms1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010390 VERSION NP_010390.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180413.3 REFERENCE 1 (residues 1 to 473) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 473) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 473) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 473) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11951. On Jul 30, 2012 this sequence version replaced NP_010390.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..473 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..473 /product="Tms1p" /calculated_mol_wt="52099" Region 10..466 /region_name="Serinc" /note="Serine incorporator (Serinc); pfam03348" /db_xref="CDD:460891" CDS 1..473 /gene="TMS1" /locus_tag="YDR105C" /coded_by="NM_001180413.3:1..1422" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:39271159]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /note="Putative scramblase involved in ESCRT-III-dependent membrane remodeling; localizes to the endosome and vacuolar membrane; predicted to contain eleven transmembrane helices; synergistic defect with VPS55 and VPS68 in the sorting of MVB cargo proteins; interacts physically with ESCRT-III subunits; conserved member of the SERINC (serine incorporator) protein family" /db_xref="GeneID:851682" /db_xref="SGD:S000002512" ORIGIN 1 mgavislpvs magsfvascf ggccsnlvtk tasslgsssl gtrllyavwl llnsliswvs 61 ysanksilwp gktctgtgec gfftvhrlnf algclhlila lvltgvkstn dvraalqnsw 121 wslkfilylc livlsfvipn dfyiffskwv svpsgaifil vglillvdfa hewaetcish 181 vesededssf wqrflvlgtt smytasiimt vvmyvmfchq qcnmnqtavt vnliltvitl 241 vlsvnpkiqe anpksglaqs smvsvyctyl tmsamssepd dkmcnplvrs sgtrkfsiil 301 gslftfiaia ytttraaans afqgtntnga iylgndieye glggqtrnql ryeaikqave 361 egslpesaly dtawlgtssp tgamdnqndd ertgtkynyt lfhvifflat qwiailltin 421 vtqddvgdfi pvgrtyfysw vkivsawicy alygwtvvap aimpdrfdye nyy // LOCUS NP_010391 284 aa linear PLN 30-JUN-2025 DEFINITION Arp10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010391 VERSION NP_010391.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180414.1 REFERENCE 1 (residues 1 to 284) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 284) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 284) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 284) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11952. Method: conceptual translation. FEATURES Location/Qualifiers source 1..284 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..284 /product="Arp10p" /calculated_mol_wt="32887" Region 6..>205 /region_name="ASKHA_ATPase-like" /note="ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; cl49607" /db_xref="CDD:483947" CDS 1..284 /gene="ARP10" /locus_tag="YDR106W" /coded_by="NM_001180414.1:1..855" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11011149]" /experiment="EXISTENCE:genetic interaction:GO:0000278 mitotic cell cycle [PMID:16291862]" /experiment="EXISTENCE:physical interaction:GO:0005200 structural constituent of cytoskeleton [PMID:16291862]" /experiment="EXISTENCE:physical interaction:GO:0005869 dynactin complex [PMID:16291862]" /note="Component of the dynactin complex; localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex" /db_xref="GeneID:851683" /db_xref="SGD:S000002513" ORIGIN 1 msntivivyl ganrieigrs adacpqeiia wktgsinekn reelkkifeh yfqicnilgn 61 revqvliled ifisvvekri icsilfkefd cahvsfvpra ivhclscntr naividigtn 121 yttcvpifdl rplqqfikys krgkrqvesr iplpgslymp iffdeeynsk ncevdetpvi 181 nlvknivesl pidlrrplre niiivnieea yetvirnlfk lkmdtskiqf pknywqagsa 241 cakillhykg snivgierde fynnphiapd wfdyyfrtgv krlq // LOCUS NP_010392 672 aa linear PLN 30-JUN-2025 DEFINITION Tmn2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010392 VERSION NP_010392.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180415.1 REFERENCE 1 (residues 1 to 672) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 672) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 672) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 672) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11953. Method: conceptual translation. FEATURES Location/Qualifiers source 1..672 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..672 /product="Tmn2p" /calculated_mol_wt="76216" Region 68..629 /region_name="EMP70" /note="Endomembrane protein 70; pfam02990" /db_xref="CDD:460774" CDS 1..672 /gene="TMN2" /locus_tag="YDR107C" /coded_by="NM_001180415.1:1..2019" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20681974]" /experiment="EXISTENCE:genetic interaction:GO:0006878 intracellular copper ion homeostasis [PMID:20681974]" /experiment="EXISTENCE:genetic interaction:GO:0007034 vacuolar transport [PMID:20526336]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:18178563]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:18178563]" /note="Protein with a role in cellular adhesion and filamentous growth; similar to Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments; TMN2 has a paralog, EMP70, that arose from the whole genome duplication" /db_xref="GeneID:851685" /db_xref="SGD:S000002514" ORIGIN 1 mkrgvwlliy cyatltkgfs lpglspttyh sgdeipllvn rltpsiyfqh qdeegndvsg 61 dkehflysyd yynkrfhfcr pehvekqpes lgsvifgdri ynspfqlnml eekecvalck 121 stipgkdakf intliksgff qnwlvdglpa arkaydsrtk tnyygtgfel gftdvkqtvd 181 gkavpstmee ltseasnedv ildarlpknv kpnlvktvel pyfvnhfdie vefhdrgndn 241 yrvvgvivnp vsiersspga csttgkplil dedkdnevyf tysvkfvasd tvwatrwdky 301 lhiydpqiqw fslinfsviv illssvvmhs llralksdla rynelnldne fhedsgwklg 361 hgdvfrtpsk smllsilvgs gmqlflmvmc siffaavglv spvsrgslpt vmfvlyalfg 421 fvgsyasmgv ykffrgpywk anmiltpill pgaifllivi mnffllfahs sgviparslf 481 fiillwflvs vplsfagsiv ahkqcnwdeh ptktnqiarq ipyqpwylrt aqatliagif 541 sfgsiavely fiysslwfnk ifymfgfllf sfllltltts lvtilityys lclenwlwqw 601 rsfiigglgc siytfihsil ftkfklggvi tvvlylgysl iisalccvvt gaigffssmf 661 firkiysaik ve // LOCUS NP_010393 698 aa linear PLN 30-JUN-2025 DEFINITION Trs85p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010393 VERSION NP_010393.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180416.3 REFERENCE 1 (residues 1 to 698) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 698) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 698) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 698) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11954. On Jul 30, 2012 this sequence version replaced NP_010393.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..698 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..698 /product="Trs85p" /calculated_mol_wt="80364" Region 225..666 /region_name="TRAPPC-Trs85" /note="ER-Golgi trafficking TRAPP I complex 85 kDa subunit; pfam12739" /db_xref="CDD:463688" CDS 1..698 /gene="TRS85" /locus_tag="YDR108W" /gene_synonym="GSG1; MUM1" /coded_by="NM_001180416.3:1..2097" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:20375281|PMID:27672095]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:23986483]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0031410 cytoplasmic vesicle [PMID:23129774]" /experiment="EXISTENCE:direct assay:GO:1990072 TRAPPIII protein complex [PMID:20375281]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10727015]" /experiment="EXISTENCE:genetic interaction:GO:0034497 protein localization to phagophore assembly site [PMID:27672095]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:16079147|PMID:23129774]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:16874038|PMID:16079147]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11239471]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921|PMID:20375281|PMID:16079147|PMID:16874038]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20375281|PMID:19793921|PMID:16874038|PMID:16079147]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:20375281|PMID:23129774|PMID:27672095]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:8619313]" /experiment="EXISTENCE:mutant phenotype:GO:0071255 Cvt vesicle assembly [PMID:16079147]" /note="Component of transport protein particle (TRAPP) complex III; TRAPPIII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating endosome-Golgi traffic and required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role" /db_xref="GeneID:851686" /db_xref="SGD:S000002515" ORIGIN 1 mvfsyehymn llfhldnske tvppeiakri isnaiapvit vtstplfdkh iqetykvdsl 61 ymllrffggc vsdrdqanea kvgqhehevc dasdstdsip knknlevpnl skkgsrsrsn 121 slfqrdstqs qyirftrplg dlietrdand mlfnyhslev fldnylklva antdemvphn 181 llkksiyhsf fslaisstnn lspyetfnhp ilslialdis ngevyedard llvnfknlnh 241 ntenfpifmn tnemlpvfll cynddsqeef ekcqalakkl kkqlfvesil lalwkdsfiy 301 densviqlhq pvmssleeil fflqaptqtt lslalinsiy dmldylvydl mipfmkrkvs 361 fweetilqpr kslfngakff kkfmnknpvn gnhqhnsltr dsqgneyfas ssseflmrkl 421 adwsmmlsdf ktaystyesl mddldafpky lasciewcav sllmgaqsiv tvkmikndin 481 plieralaty encsriqrgk gkesnsldvt epvrsyetrc milaselfls lsntwtstpy 541 aiqyletild ecklgpcsqi mvwerlsdcy nlrvdprikh rvgamkkdak dtedlrgehk 601 ystdhftded ilsegltrrr kaaffrliaa kkwaeqkqwr qvswclkdie styseikflh 661 gnglilsklk nqlnlkdvds aprpseknlt rtsvsfig // LOCUS NP_010394 715 aa linear PLN 30-JUN-2025 DEFINITION putative phosphotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010394 VERSION NP_010394.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180417.3 REFERENCE 1 (residues 1 to 715) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 715) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 715) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 715) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11955. On Jul 30, 2012 this sequence version replaced NP_010394.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..715 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..715 /product="putative phosphotransferase" /EC_number="2.7.1.47" /calculated_mol_wt="79030" Region 39..703 /region_name="ASKHA_NBD_FGGY_D-RBK" /note="nucleotide-binding domain (NBD) of D-ribulokinase FGGY and similar proteins; cd07782" /db_xref="CDD:466800" CDS 1..715 /locus_tag="YDR109C" /coded_by="NM_001180417.3:1..2148" /experiment="EXISTENCE:direct assay:GO:0019150 D-ribulokinase activity [PMID:27909055]" /experiment="EXISTENCE:direct assay:GO:0019321 pentose metabolic process [PMID:27909055]" /experiment="EXISTENCE:mutant phenotype:GO:0019321 pentose metabolic process [PMID:27909055]" /note="D-ribulokinase; carbohydrate kinase that specifically converts D-ribulose to D-ribulose 5-phosphate during pentose metabolism; null mutant accumulates D-ribulose and the precursor ribitol; proposed to function as a D-ribulose metabolic repair enzyme; member of the FGGY family of carbohydrate kinases; human homolog, FGGY, is involved in both D-ribulose and ribitol metabolism; human FGGY has been linked to both sporadic amyotrophic lateral sclerosis and bipolar disorder" /db_xref="GeneID:851687" /db_xref="SGD:S000002516" ORIGIN 1 mksrkrqnnm qnetrepavl ssqetsisri spqdpeakfy vgvdvgtgsa racvidqsgn 61 mlslaekpik reqlisnfit qssreiwnav cycvrtvvee sgvdpervrg igfdatcslv 121 vvsatnfeei avgpdftnnd qniilwmdhr amketeeins sgdkclkyvg gqmsvemeip 181 kikwlknnle agifqdckff dlpdyltfka tgkenrsfcs avckqgflpv gvegsdigws 241 keflnsigls eltkndferl ggslrekknf ltagecispl dkkaacqlgl tehcvvssgi 301 idayagwvgt vaakpesavk glaetenykk dfngaigrla avagtstchi llsknpifvh 361 gvwgpyrdvl argfwaaegg qsctgvlldh litthpafte lshmanlagv skfeylnkil 421 etlvekrkvr svislakhlf fygdyhgnrs piadpnmrac iigqsmdnsi edlavmylsa 481 cefisqqtrq iievmlksgh einaifmsgg qcrnsllmrl ladctglpiv ipryvdaavv 541 fgsallgaaa sedfdytrek rtlkgqkssq tkterfndsy ssiqklsmed rnstngfvsp 601 hnlqlstpsa pakinnyslp ictqqpldkt seesskdasl tvgqeslgeg ryngtsflwk 661 vmqeltgnar ivnpnekthp drilldtkyq ifldmietqr kyrrmvdkve gsfsr // LOCUS NP_010395 566 aa linear PLN 30-JUN-2025 DEFINITION replication fork barrier binding protein FOB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010395 VERSION NP_010395.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180418.1 REFERENCE 1 (residues 1 to 566) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 566) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 566) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 566) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11956. Method: conceptual translation. FEATURES Location/Qualifiers source 1..566 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..566 /product="replication fork barrier binding protein FOB1" /calculated_mol_wt="65188" CDS 1..566 /gene="FOB1" /locus_tag="YDR110W" /gene_synonym="HRM1" /coded_by="NM_001180418.1:1..1701" /experiment="EXISTENCE:direct assay:GO:0000183 rDNA heterochromatin formation [PMID:12923057]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10230397]" /experiment="EXISTENCE:direct assay:GO:0008156 negative regulation of DNA replication [PMID:14645529]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:22362748]" /experiment="EXISTENCE:direct assay:GO:0043110 rDNA spacer replication fork barrier binding [PMID:14645529]" /experiment="EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:26951198]" /experiment="EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:16769819]" /experiment="EXISTENCE:genetic interaction:GO:0043007 maintenance of rDNA [PMID:23593017]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:26951198]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:9078378]" /experiment="EXISTENCE:mutant phenotype:GO:0031582 replication fork arrest at rDNA repeats [PMID:26951198]" /experiment="EXISTENCE:mutant phenotype:GO:0034503 protein localization to nucleolar rDNA repeats [PMID:19362534]" /experiment="EXISTENCE:mutant phenotype:GO:0043110 rDNA spacer replication fork barrier binding [PMID:26951198]" /experiment="EXISTENCE:mutant phenotype:GO:0043570 maintenance of DNA repeat elements [PMID:16507999]" /experiment="EXISTENCE:mutant phenotype:GO:0045911 positive regulation of DNA recombination [PMID:25822194]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:18923139]" /note="Nucleolar protein that binds the rDNA replication fork barrier site; required for replication fork blocking and recombinational hotspot activity that results in concerted evolution of the rDNA, termed homogenization; role in recruitment of condensin to the replication fork barrier (RFB), contributing to the faithful segregation of rDNA repeats; proposed role in recovery from low rDNA copy number; related to retroviral integrases" /db_xref="GeneID:851688" /db_xref="SGD:S000002517" ORIGIN 1 mtkpryndvl fddddsvpse svtrksqrrk atspgesres skdrllilps mgesyteyvd 61 sylnleller geretpifle sltrqltqki yeliktkslt adtlqqisdk ydgvvaenkl 121 lflqrqyyvd degnvrdgrn ndkiycepkh vydmvmathl mnkhlrgktl hsflfshfan 181 ishaiidwvq qfcskcnkkg kikplkeykr pdmydkllpm erihievfep fngeaiegky 241 syvllcrdyr ssfmwllplk stkfkhlipv vsslfltfar vpifvtsstl dkddlydice 301 eiaskyglri glglkssarf htggilciqy alnsykkecl adwgkclryg pyrfnrrrnk 361 rtkrkpvqvl lsevpghnak fetkrervie ntysrnmfkm aggkgliyle dvntfalane 421 adnscnnngi lhnnnigndn feeevqkqfd lteknyidey ddlahdsseg efepntltpe 481 ekpphnvded riestgvaap mqgteepekg dqkesdgasq vdqsveitrp etsyyqtles 541 pstkrqkldq qgngdqtrdf gtsmel // LOCUS NP_010396 507 aa linear PLN 30-JUN-2025 DEFINITION alanine transaminase ALT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010396 VERSION NP_010396.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180419.1 REFERENCE 1 (residues 1 to 507) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 507) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 507) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 507) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11957. Method: conceptual translation. FEATURES Location/Qualifiers source 1..507 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..507 /product="alanine transaminase ALT2" /calculated_mol_wt="56639" Region 26..505 /region_name="PTZ00377" /note="alanine aminotransferase; Provisional" /db_xref="CDD:240391" CDS 1..507 /gene="ALT2" /locus_tag="YDR111C" /coded_by="NM_001180419.1:1..1524" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030170 pyridoxal phosphate binding [PMID:29867852]" /note="Catalytically inactive alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p; ALT2 has a paralog, ALT1, that arose from the whole genome duplication" /db_xref="GeneID:851690" /db_xref="SGD:S000002518" ORIGIN 1 mtmthqqdlk gvftakdldf kpagkitkkd lntgvtkaey avrgaiptra delkeelkkn 61 pevlpfddii nanignpqql dqkpltftrq vlaileypei lrvghnelas lnlfsrdale 121 raerllndig gsigayshsq gvpgirqtva dfitrrdgge patpediylt tgassaatsl 181 lsllckdsqt gllipipqyp lytasaslfn aqvlpyylde esnwstnsde iekvvqdalk 241 kqirpsvliv inpgnptgav lseetiaric liaakygiti isdevyqeni fndvkfhsmk 301 kvlrklqhly pgkfdnvqla slhsiskgfm decgqrggym eiigfsqeir dalfklmsis 361 icsvvtgqav vdlmvkppqp gdesyeqdhd erlkifhemr tranllyetf kelegiecqk 421 pqgamylfpr lvlpkkalce serlgiepde fyctsllest gictvpgsgf gqrpgtyhvr 481 ttflapgtkw iqdwkefhqd ffskyrn // LOCUS NP_010398 373 aa linear PLN 30-JUN-2025 DEFINITION securin [Saccharomyces cerevisiae S288C]. ACCESSION NP_010398 VERSION NP_010398.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180421.3 REFERENCE 1 (residues 1 to 373) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 373) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 373) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 373) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11958. On Jul 30, 2012 this sequence version replaced NP_010398.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..373 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..373 /product="securin" /calculated_mol_wt="41707" Region 9..326 /region_name="Securin" /note="Securin sister-chromatid separation inhibitor; pfam04856" /db_xref="CDD:461456" CDS 1..373 /gene="PDS1" /locus_tag="YDR113C" /coded_by="NM_001180421.3:1..1122" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11149918|PMID:19520826]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19520826]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:11149918]" /experiment="EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:15533838]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:27325700]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:9635435]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:15533838]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:27418100]" /experiment="EXISTENCE:mutant phenotype:GO:0007127 meiosis I [PMID:19001291]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:11149918]" /experiment="EXISTENCE:physical interaction:GO:0019899 enzyme binding [PMID:11149918|PMID:9635435]" /note="Securin; inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation" /db_xref="GeneID:851691" /db_xref="SGD:S000002520" ORIGIN 1 mmpanedken nivytgness ginfpqtpah llkrshsnil kppvrldqlk rdansnngnt 61 lkyiqggkev sptkrlhtha qqqgrlplaa kdnnrsksfi fpetsnqskd adlpqlqntl 121 sirkndqlrk lsqisrsrsr anhndllsns rklqkygsvl gynalpkmks lvlkdladsg 181 kneessddde gnedsesklg kklqsallkq dssdgeneln gglglfneqg glqqliknst 241 kneqktkndk sdktddydie iapqrqeplp yvpegyspfq qddieklktf nspykldled 301 eddtpdkvdl lpleqideeg ekdetecitr nqeegaalpl lsknfkevaa vptmelvyse 361 egldpeeled lvt // LOCUS NP_010399 100 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR114C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010399 VERSION NP_010399.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180422.3 REFERENCE 1 (residues 1 to 100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 100) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11959. On Jul 30, 2012 this sequence version replaced NP_010399.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..100 /product="uncharacterized protein" /calculated_mol_wt="11832" CDS 1..100 /locus_tag="YDR114C" /coded_by="NM_001180422.3:1..303" /note="hypothetical protein; deletion mutant exhibits poor growth at elevated pH and calcium" /db_xref="GeneID:851693" /db_xref="SGD:S000002521" ORIGIN 1 mktfflieag ralqivafrp aittvlfqrf svsfscsyft cctsqllren wlfkfltafd 61 hvirasndls tmrfmimyiy vyiyiytvlr krlscymlil // LOCUS NP_010400 105 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL34m MRX14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010400 VERSION NP_010400.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180423.1 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11960. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..105 /product="mitochondrial 54S ribosomal protein bL34m MRX14" /calculated_mol_wt="11899" Region 63..104 /region_name="Ribosomal_L34" /note="Ribosomal protein L34; pfam00468" /db_xref="CDD:425699" CDS 1..105 /gene="MRX14" /locus_tag="YDR115W" /gene_synonym="bL34m" /coded_by="NM_001180423.1:1..318" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /note="Putative mitochondrial ribosomal protein of the large subunit; required for respiratory growth and for efficient translation of mitochondrial COX1 and COX3; conditional mutant has reduced cytochrome c oxidase activity; protein increases in abundance and relocalizes to the plasma membrane upon DNA replication stress; contains and N-terminal mitochondrial targeting sequence; similar to E. coli L34 ribosomal protein" /db_xref="GeneID:851692" /db_xref="SGD:S000002522" ORIGIN 1 mplfarlcqp qsrrmfssis sfsalsvlrp qtgmllnssp lktpsftplg fgligqrrwk 61 srgntyqpst lkrkrtfgfl arakskqgsk ilkrrklkgr wflsh // LOCUS NP_010401 285 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL1m MRPL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010401 VERSION NP_010401.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180424.1 REFERENCE 1 (residues 1 to 285) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 285) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 285) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 285) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11961. Method: conceptual translation. FEATURES Location/Qualifiers source 1..285 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..285 /product="mitochondrial 54S ribosomal protein uL1m MRPL1" /calculated_mol_wt="30865" Region 75..216 /region_name="rplA_mito" /note="ribosomal protein uL1, mitochondrial; TIGR01170" /db_xref="CDD:273480" Site order(92..94,97,99,101,224,226,228,276..277,279) /site_type="other" /note="mRNA/rRNA interface [nucleotide binding]" /db_xref="CDD:238235" CDS 1..285 /gene="MRPL1" /locus_tag="YDR116C" /gene_synonym="uL1m" /coded_by="NM_001180424.1:1..858" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:851694" /db_xref="SGD:S000002523" ORIGIN 1 mlsvvaipki cvtgparrcf fhtakklyad dykpaamssn apsltkdqak krelkrlvqr 61 kaeakrpata splympvtka lrylraaevg rpqsqqtinl ttlvvgergt aplsgsvtfp 121 kplryikiaa ftndesklee lrekypnhli ggadlvakik sgeisvdfdk afatpdivpa 181 lqsqvarilg prgvlpsvkk gtvsddissl lqeslgsmpf rqrgnsisig vgkcyftdre 241 ilqniisara afktavdnqk skkpnilskt tlssthgpgi vidfa // LOCUS NP_010402 565 aa linear PLN 30-JUN-2025 DEFINITION Tma64p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010402 VERSION NP_010402.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180425.3 REFERENCE 1 (residues 1 to 565) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 565) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 565) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 565) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11962. On Jul 30, 2012 this sequence version replaced NP_010402.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..565 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..565 /product="Tma64p" /calculated_mol_wt="63861" Region 2..86 /region_name="Pre-PUA" /note="Pre-PUA-like domain; pfam17832" /db_xref="CDD:436077" Region 88..170 /region_name="PUA_eIF2d-like" /note="PUA RNA-binding domain of eukaryotic translation initiation factor 2D and similar proteins; cd21156" /db_xref="CDD:409298" Site order(97..98,102,107..108,110) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:409298" Region 474..556 /region_name="eIF2D_C" /note="C-terminal domain of eIF2D and related proteins; cd11608" /db_xref="CDD:211321" Site order(482,485..486,488,506,509..511,513..515,517,532,535) /site_type="other" /note="putative rRNA binding site [nucleotide binding]" /db_xref="CDD:211321" CDS 1..565 /gene="TMA64" /locus_tag="YDR117C" /coded_by="NM_001180425.3:1..1698" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:14759368]" /experiment="EXISTENCE:physical interaction:GO:0006364 rRNA processing [PMID:14759368]" /note="hypothetical protein that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity" /db_xref="GeneID:851695" /db_xref="SGD:S000002524" ORIGIN 1 mfkkephika lsnlknserk kllqtfqkqt nneeysfrts tikqtnfngq ksvgtvytde 61 nntpilfkek hkeqlfptvy scweypallp ivlthgfvie ehlfnganlm isgsippfdp 121 rckigtlcgi askqapetvl aigiveldlp sfdkvigetg vavkiihhfn dglskvfkmk 181 leppfvlstq skdnnisskq iesseqikav ekeqedvkea svdveeiaev ldhftvsdvd 241 yfitralyyt ltqdkglelp isasnfisnh imrnlppidh nevnvkktsw kksakflkhf 301 ekegflklkg kgddltivgk ntdkdelknf vpyklgcsks atesrestts kektsgmmys 361 ltlykpfnla kdllkevnla shtyytsqdi rsavsqyisv knladtkdkg kvimddllfd 421 mvnkkkkvln asriiargei lhplltnnft efyqifksdd tllfkapmkg slphikiite 481 mkigrkvitr vsnfevfqvd peslaadlrk icsgsttise sqtfkcaevq vqgphgqsii 541 dhlnklgips kwidfenklk kkkrk // LOCUS NP_010403 652 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit 4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010403 VERSION NP_010403.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180426.3 REFERENCE 1 (residues 1 to 652) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 652) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 652) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 652) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 652) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 652) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 652) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 652) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 652) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11963. On Jul 30, 2012 this sequence version replaced NP_010403.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..652 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..652 /product="anaphase promoting complex subunit 4" /calculated_mol_wt="75125" Region 223..411 /region_name="ANAPC4" /note="Anaphase-promoting complex, cyclosome, subunit 4; pfam12896" /db_xref="CDD:463744" CDS 1..652 /gene="APC4" /locus_tag="YDR118W" /coded_by="NM_001180426.3:1..1959" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473]" /note="Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:851696" /db_xref="SGD:S000002525" ORIGIN 1 msspindyfi dynplfpifa triakglaiy rvsdharlav ipirninlva nydwdtttgk 61 flsiffkdgt irihdifkdg rlvsflrips tkiskgiwdr iplryepnnr dfacniiddl 121 pklirfvkds krinivpytq pnslwrgpde ddldsnekld vhvvfnegnd kitvffngdy 181 avflsvdnie nenslksiik vqdgfyqcfy edgtvqtlnl gpllqskssv nllnyimvik 241 eligymlthl efinrelatp yldfvkrlcd eaygygklks elealfllge iscdledwlc 301 nsvgeknfkr wkylgceayq ktvqiltlif vpaceriiiy veklrailqa fsiqnklsyt 361 sdltavevll kssqklltmt lnsiiglgrd etlfekffiw fndrlheald edyklkfqfe 421 ddlyfgydll syfdrilskk gtepssiidv klyrdlinsm sdmekdiaqs nvnshiqqhi 481 lvdlktdvfa qkypssqinl ldaiklpkhn yivyliqvtk hnsaqepfse enkkklyigt 541 lkdenlgiis kessvkipal fksyrlsstr fvpnrvhsll rdiglsdsny hsshvtdyrg 601 enyeneeddg tiaipayire nrenddfiac takvsvdgrs aslvfpkekq nv // LOCUS NP_010404 768 aa linear PLN 30-JUN-2025 DEFINITION Vba4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010404 VERSION NP_010404.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180427.1 REFERENCE 1 (residues 1 to 768) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 768) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 768) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 768) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 768) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 768) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 768) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 768) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 768) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11964. Method: conceptual translation. FEATURES Location/Qualifiers source 1..768 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..768 /product="Vba4p" /calculated_mol_wt="85552" Region 246..665 /region_name="AraJ" /note="Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; COG2814" /db_xref="CDD:442063" Region 259..>414 /region_name="MFS" /note="Major Facilitator Superfamily; cl28910" /db_xref="CDD:475125" CDS 1..768 /gene="VBA4" /locus_tag="YDR119W" /coded_by="NM_001180427.1:1..2307" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:14562095]" /note="hypothetical protein; proposed role as basic amino acid permease based on phylogeny; targeted to vacuole via AP-3 pathway; physical interaction with Atg27p suggests possible role in autophagy; non-essential gene" /db_xref="GeneID:851697" /db_xref="SGD:S000002526" ORIGIN 1 mgkkdrqrkk lrefaklknr qrnlrksvqt lknevqreak vprtsnqial gndkieeine 61 nspllsapsk qeevsipkav didtidaqpl hegpkiddsp qdevnsikgk padkaneddl 121 kppsqheacg nsalqssitd fsdrsvsplq sitscntpms ehelpvsssn sferaddmpv 181 vqadnqtsss kslhivapsp evpvsgdeit sygygsipqs igdvenglnp pyventssde 241 lvhdltrrri fsscmctylf fiamdssiil viaskiasef helwrlslvi sayllsnaig 301 qlvflklsli ssvklllcia qfsfilggyl swssahfwtf ifarcvtgfg ggslialkst 361 imnrfsqknd sryslsasmi tfamgvvigp fmmnlfdssh gsgwrnafli pvpfclvnas 421 imladmysvk stlygrptpt lwkrfkntll spdlyeiltl tlfllcfvqv tsldltglkn 481 ntmiqallfs viivcgilff lietsdtymn svismslqgd krliwtmigi sfcfaalmci 541 ipfgttyfii vlnlstlqla erlspfffsi vlgyfsvsyf wkskgqnfll kfvlsgatll 601 lyvalmgvsl nlpvwkqyic lslpflgssm iltllsnlyh eyheqrkspi sgsivycfga 661 vggtvgislg gyvfhktlik lmhekvmpfs kqgylkkdll kiikhatess dwvhesapkf 721 vfqtliecyl qacrnvfkls tlfftitvva ififnrihcr sqnclsls // LOCUS NP_001032575 66 aa linear PLN 30-JUN-2025 DEFINITION Cox26p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032575 VERSION NP_001032575.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184681.1 REFERENCE 1 (residues 1 to 66) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 66) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 66) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 66) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11965. Method: conceptual translation. FEATURES Location/Qualifiers source 1..66 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..66 /product="Cox26p" /calculated_mol_wt="7321" CDS 1..66 /gene="COX26" /locus_tag="YDR119W-A" /coded_by="NM_001184681.1:1..201" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:22342701]" /experiment="EXISTENCE:direct assay:GO:0098803 respiratory chain complex [PMID:27091403]" /experiment="EXISTENCE:mutant phenotype:GO:0045277 respiratory chain complex IV [PMID:27091403]" /note="Subunit of cytochrome C oxidase complex; stabilizes or regulates formation of respiratory chain supercomplexes composed of Complex III (ubiquinol-cytochrome c reductase) and Complex IV (cytochrome c oxidase)" /db_xref="GeneID:3799970" /db_xref="SGD:S000113555" ORIGIN 1 mffsqvlrss araapikryt ggrigeswvi tegrrlipei fqwsavlsvc lgwpgavyff 61 skarka // LOCUS NP_010405 570 aa linear PLN 30-JUN-2025 DEFINITION tRNA (guanine26-N2)-dimethyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010405 VERSION NP_010405.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180428.3 REFERENCE 1 (residues 1 to 570) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 570) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 570) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 570) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11966. On Jul 30, 2012 this sequence version replaced NP_010405.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..570 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..570 /product="tRNA (guanine26-N2)-dimethyltransferase" /EC_number="2.1.1.216" /calculated_mol_wt="63921" Region 45..495 /region_name="TRM1" /note="tRNA(guanine-26,N2-N2) methyltransferase; TIGR00308" /db_xref="CDD:273006" Site order(139..145,164..165,190..192,213) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..570 /gene="TRM1" /locus_tag="YDR120C" /coded_by="NM_001180428.3:1..1713" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:7599275]" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:7599275]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:7599275]" /experiment="EXISTENCE:direct assay:GO:0160103 tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity [PMID:9801306]" /experiment="EXISTENCE:mutant phenotype:GO:0005637 nuclear inner membrane [PMID:19602197]" /experiment="EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:2426253]" /experiment="EXISTENCE:mutant phenotype:GO:0160103 tRNA (guanine(26)-N2/guanine(27)-N2)-dimethyltransferase activity [PMID:9801306]" /note="tRNA methyltransferase; produces two isoforms based on alternative translational starts; localizes to the nucleus and mitochondrion, producing N2,N2-dimethylguanosine in tRNAs; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; nuclear Trm1p is evenly distributed around the inner nuclear membrane in WT, but mislocalizes as puncta near ER-nucleus junctions in spindle pole body mutants; both Trm1p inner nuclear membrane targeting and maintenance depend upon the SPB" /db_xref="GeneID:851698" /db_xref="SGD:S000002527" ORIGIN 1 megffriplk ranlhgmlka aiskikanft aygaprinie dfnivkegka eilfpkketv 61 fynpiqqfnr dlsvtcikaw dnlygeecgq krnnkkskkk rcaetnddss krqkmgngsp 121 keavgnsnrn epyinileal satglrairy aheiphvrev iandllpeav esikrnveyn 181 svenivkpnl ddanvlmyrn katnnkfhvi dldpygtvtp fvdaaiqsie egglmlvtct 241 dlsvlagngy pekcfalygg anmvshesth esalrlvlnl lkqtaakykk tvepllslsi 301 dfyvrvfvkv ktspievknv msstmttyhc srcgsyhnqp lgrisqregr nnktftkysv 361 aqgppvdtkc kfcegtyhla gpmyagplhn kefieevlri nkeehrdqdd tygtrkrieg 421 mlslaknels dspfyfspnh iasviklqvp plkkvvaglg slgfecslth aqpsslktna 481 pwdaiwyvmq kcddekkdls kmnpnttgyk ilsampgwls gtvkseydsk lsfapneqsg 541 nieklrklki vryqenptkn wgpkarpnts // LOCUS NP_010406 196 aa linear PLN 30-JUN-2025 DEFINITION DNA polymerase epsilon noncatalytic subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_010406 VERSION NP_010406.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180429.3 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11967. On Jul 30, 2012 this sequence version replaced NP_010406.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..196 /product="DNA polymerase epsilon noncatalytic subunit" /calculated_mol_wt="21866" Region 30..118 /region_name="HFD_POLE3_DPB4" /note="histone-fold domain found in DNA polymerase epsilon subunit 3 (POLE3) and similar proteins; cd22928" /db_xref="CDD:467053" Site order(30,65,69,72..73,76..77,92..93,101,106,112..113,116) /site_type="other" /note="catalytic subunit binding site [polypeptide binding]" /db_xref="CDD:467053" Site order(37,41..42,44,55..56,58..59,62..63,65..67,69..75, 88..92,95,102..104,107,110..111,114..115,117..118) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467053" CDS 1..196 /gene="DPB4" /locus_tag="YDR121W" /coded_by="NM_001180429.3:1..591" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:16916794|PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:14622139|PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:19595716]" /experiment="EXISTENCE:direct assay:GO:0008622 epsilon DNA polymerase complex [PMID:12571237|PMID:11024162]" /experiment="EXISTENCE:direct assay:GO:0008623 CHRAC [PMID:15024052|PMID:14673157]" /experiment="EXISTENCE:direct assay:GO:0030337 DNA polymerase processivity factor activity [PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0031490 chromatin DNA binding [PMID:17491017]" /experiment="EXISTENCE:direct assay:GO:0031492 nucleosomal DNA binding [PMID:19595716]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:19776424]" /experiment="EXISTENCE:genetic interaction:GO:0006272 leading strand elongation [PMID:21124948]" /experiment="EXISTENCE:genetic interaction:GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity [PMID:21124948]" /experiment="EXISTENCE:genetic interaction:GO:0030337 DNA polymerase processivity factor activity [PMID:21124948]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:11024162]" /experiment="EXISTENCE:mutant phenotype:GO:0006272 leading strand elongation [PMID:21124948]" /experiment="EXISTENCE:mutant phenotype:GO:1903775 regulation of DNA double-strand break processing [PMID:34362907]" /experiment="EXISTENCE:physical interaction:GO:0008622 epsilon DNA polymerase complex [PMID:15024052]" /experiment="EXISTENCE:physical interaction:GO:0008623 CHRAC [PMID:15024052]" /note="Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex; involved in both chromosomal DNA replication and inheritance of telomeric silencing; stabilizes the interaction of Pol epsilon with primer-template DNA, positively affecting the processivity of the polymerase and exonuclease activities of Pol epsilon; interacts with extranucleosomal DNA and acts as anchor point for ISW2 complex that retains its position on DNA during nucleosome mobilization" /db_xref="GeneID:851699" /db_xref="SGD:S000002528" ORIGIN 1 mppkgwrkda qgnypttsyi keqenitiqd llfpkstivn larevpqqsg kkllinkdas 61 lalqrgatvf vnhlllfare iaksqdkksc svddvlsald highsalkgp vrdkldeyqa 121 aveqrkkekl dsgevdadgd idmgedkenv pvekvkehde ieeqgdalqd veessekkqk 181 tesqdvetrv qnleqt // LOCUS NP_010407 1064 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase KIN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010407 VERSION NP_010407.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180430.1 REFERENCE 1 (residues 1 to 1064) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1064) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1064) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1064) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1064) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1064) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1064) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1064) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1064) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11968. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1064 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1064 /product="serine/threonine protein kinase KIN1" /EC_number="2.7.11.1" /calculated_mol_wt="119940" Region 118..398 /region_name="STKc_Kin1_2" /note="Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; cd14077" /db_xref="CDD:270979" Site order(126..130,134,147,149,207,223..226,230,232..233,235, 268..269,271,273..274,276,286..287,290,304..308,310, 340..343) /site_type="active" /db_xref="CDD:270979" Site order(126..129,134,147,149,207,223..226,230,273..274,276, 286..287) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270979" Site order(230,232..233,235,269,271,273,290,304..308,310, 340..343) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270979" Site 286..308 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270979" Region 890..1062 /region_name="MARK_C_like" /note="C-terminal kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases, and similar domains; cd12121" /db_xref="CDD:213377" Site order(892,1040,1042..1043) /site_type="other" /note="putative phospholipid binding site [chemical binding]" /db_xref="CDD:213377" CDS 1..1064 /gene="KIN1" /locus_tag="YDR122W" /coded_by="NM_001180430.1:1..3195" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:30305396|PMID:8203145|PMID:1652871]" /experiment="EXISTENCE:direct assay:GO:0009898 cytoplasmic side of plasma membrane [PMID:8020610]" /experiment="EXISTENCE:genetic interaction:GO:0045921 positive regulation of exocytosis [PMID:15563607]" /experiment="EXISTENCE:genetic interaction:GO:1903896 positive regulation of IRE1-mediated unfolded protein response [PMID:25348718]" /experiment="EXISTENCE:physical interaction:GO:0005886 plasma membrane [PMID:15563607]" /experiment="EXISTENCE:physical interaction:GO:0045921 positive regulation of exocytosis [PMID:15563607]" /note="S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated unfolded protein response; regulates HAC1 mRNA translocation, splicing and translation with KIN2 during ER stress; direct phosphorylation of the substrate Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the plasma membrane; activation loop phosphorylation (T302) required for full kinase activity; orthologous to MARK/PAR-1, AMP-activated protein kinase (AMPK) family members" /db_xref="GeneID:851700" /db_xref="SGD:S000002529" ORIGIN 1 mddyhvntaf smgrgnqqdd gnsesnsmht qpstmapatl rmmgkspqqq qqqntplmpp 61 adikyanngn shqaeqkerq velegksren apkpnttsqs rvsssqgmpk qfhrkslgdw 121 efvetvgags mgkvklakhr ytnevcavki vnratkaflh keqmlpppkn eqdvlerqkk 181 lekeisrdkr tireaslgqi lyhphicrlf emctlsnhfy mlfeyvsggq lldyiiqhgs 241 irehqarkfa rgiasaliyl hannivhrdl kienimisds seikiidfgl sniydsrkql 301 htfcgslyfa apellkanpy tgpevdvwsf gvvlfvlvcg kvpfddenss vlhekikqgk 361 veypqhlsie visllskmlv vdpkrratlk qvvehhwmvr gfngpppsyl pkrvpltiem 421 ldinvlkemy rlefiddvee trsvlvsiit dptyvllsrq ywtlaakmna essdngnapn 481 itesfedptr ayhpmisiyy ltsemldrkh akirnqqqrq shenieklse ipesvkqrdv 541 evnttamkse peatlatkdt svpftpknsd gtepplhvli pprlampeqa htsptsrkss 601 dnqrremeya lsptpqgndy qqfrvpsttg dpsekakfgn ifrklsqrrk ktieqtsvns 661 nnsinkpvqk thsravsdfv pgfakpsyds nytmnepvkt ndsrggnkgd fpalpadaen 721 mvekqrekqi eedimklhdi nkqnnevakg sgreayaaqk fegsdddenh plpplnvakg 781 rklhpsarak svgharresl kymrppmpss aypqqelidt gflessddnk sdslgnvtsq 841 tndsvsvhsv nahinspsve keltdeeilq easrapagsm psidfprslf lkgffsvqtt 901 sskplpivry kimfvlrkmn iefkevkggf vcmqrfssnn vaakregtpr simplshhes 961 irrqgsnkys pssplttnsi hqrktsitet ygddkhsgts lenihqqgdg segmttteke 1021 pikfeihivk vrivglagvh fkkisgntwl ykelassilk elkl // LOCUS NP_010408 304 aa linear PLN 30-JUN-2025 DEFINITION Ino2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010408 VERSION NP_010408.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180431.1 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11969. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..304 /product="Ino2p" /calculated_mol_wt="34103" Region 235..302 /region_name="bHLH_ScINO2_like" /note="basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; cd11388" /db_xref="CDD:381394" Site order(238,240..242,244..246,248..249,253,275..276) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:381394" Site order(252,255..256,258..259,263..264,277,280..281,284, 286..288,290..291,293..294,297,300..301) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:381394" CDS 1..304 /gene="INO2" /locus_tag="YDR123C" /gene_synonym="DIE1; SCS1" /coded_by="NM_001180431.1:1..915" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8195172]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8195172]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8012448|PMID:15455074]" /experiment="EXISTENCE:direct assay:GO:0090575 RNA polymerase II transcription regulator complex [PMID:8195172]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8195172]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:8125958]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8125958]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8195172]" /experiment="EXISTENCE:physical interaction:GO:0090575 RNA polymerase II transcription regulator complex [PMID:8195172]" /note="Transcription factor; component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion; involved in diauxic shift" /db_xref="GeneID:851701" /db_xref="SGD:S000002530" ORIGIN 1 mqqatgnell gildldndid fetayqmlss nfddqmsahi hentfsatsp pllthelgii 61 pnvatvqpsh vetipadnqt hhaplhthah ylnhnphqps mgfdqalglk lspsssglls 121 tnesnaieqf ldnlisqdmm ssnasmnses hlhirspkkq hrytelnqry pethphsntg 181 elptntadvp tefttregph qpigndhynp ppfsvpeiri pdsdipanie ddpvkvrkwk 241 hvqmekirri ntkeaferli ksvrtppken gkripkhill tcvmndiksi rsanealqhi 301 ldds // LOCUS NP_010409 324 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR124W [Saccharomyces cerevisiae S288C]. ACCESSION NP_010409 VERSION NP_010409.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180432.3 REFERENCE 1 (residues 1 to 324) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 324) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 324) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 324) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11970. On Jul 30, 2012 this sequence version replaced NP_010409.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..324 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..324 /product="uncharacterized protein" /calculated_mol_wt="37473" Region 82..206 /region_name="DUF2841" /note="Protein of unknown function (DUF2841); pfam11001" /db_xref="CDD:431594" CDS 1..324 /locus_tag="YDR124W" /coded_by="NM_001180432.3:1..975" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31945465]" /note="Mitochondrial hypothetical protein; null mutant show severe fragmentation of mitochondria; expression is strongly induced by alpha factor; may have role in maintenance of mitochondrial morphology" /db_xref="GeneID:851702" /db_xref="SGD:S000002531" ORIGIN 1 mrigmeelrr alallngqgy efmvfikekd hlisesipkn lfsesfisss ieknppltfd 61 plvnrkritv yeeniqpaim lpldqplliq nylytafkll rqvpckaiak lwikiieprk 121 ktrfpyikgn agrpewwpkd vehkepdhlq kadrlklmct iimnvlpqsp fsleildelt 181 gvtaamtifk ketvkkvimk nvfeiakclc nkdfkqktis lddlndlaqk qkksyhsrrf 241 dvnkmvkvek dllqqssgsd sspsmilpsk esdteyfpre ypkdpvsedy snsisrlenl 301 vefdplfltk ldeltssddc kdfi // LOCUS NP_010410 453 aa linear PLN 30-JUN-2025 DEFINITION alpha/beta hydrolase family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010410 VERSION NP_010410.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180433.3 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11971. On Jul 30, 2012 this sequence version replaced NP_010410.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..453 /product="alpha/beta hydrolase family protein" /calculated_mol_wt="53054" Region <112..442 /region_name="PLN02894" /note="hydrolase, alpha/beta fold family protein" /db_xref="CDD:215484" CDS 1..453 /gene="ECM18" /locus_tag="YDR125C" /coded_by="NM_001180433.3:1..1362" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="hypothetical protein; ECM18 has a paralog, ICT1, that arose from the whole genome duplication" /db_xref="GeneID:851703" /db_xref="SGD:S000002532" ORIGIN 1 mllikrylmd peslrrqimn vykcymwkra fhsnrsllev krrekslqrk ilerilrpke 61 enavkksgfk lwsshlnnph ktymrleelq rrimeevhve gikkndklfn einqwhfqne 121 ntstvrtptl lihgyaassm sffrnypgls khirnlysid mpasglssvp sleintttpl 181 pldikfigen kfkvpytina nhnkfviqmy edfyldrieq wridnklgkm nvvghsfggy 241 lsfkyavkyp nsvnklclvs plgverniws vnnnfhsntl ytidfknpns kfyskrnmip 301 kylfeqqfhi lrmmgplgak lcwnyimaay srvpslayke yifelfygkg gipevttdif 361 kalfsrcila kdplmdslqy lnvkkllivy gqydwmnkka gmfmvkelnn lknclegasy 421 leipssghnl fldnpesfnq sivsflsdet ksp // LOCUS NP_010411 336 aa linear PLN 30-JUN-2025 DEFINITION palmitoyltransferase SWF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010411 VERSION NP_010411.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180434.1 REFERENCE 1 (residues 1 to 336) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 336) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 336) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 336) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11972. Method: conceptual translation. FEATURES Location/Qualifiers source 1..336 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..336 /product="palmitoyltransferase SWF1" /EC_number="2.3.1.225" /calculated_mol_wt="39181" Region 22..336 /region_name="COG5273" /note="Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]" /db_xref="CDD:227598" CDS 1..336 /gene="SWF1" /locus_tag="YDR126W" /gene_synonym="PSL10" /coded_by="NM_001180434.1:1..1011" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:18701706]" /experiment="EXISTENCE:direct assay:GO:0032432 actin filament bundle [PMID:18701706]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:15973437]" /experiment="EXISTENCE:genetic interaction:GO:0042144 vacuole fusion, non-autophagic [PMID:16186255]" /experiment="EXISTENCE:mutant phenotype:GO:0016409 palmitoyltransferase activity [PMID:15973437|PMID:26224664]" /experiment="EXISTENCE:mutant phenotype:GO:0017157 regulation of exocytosis [PMID:18701706]" /experiment="EXISTENCE:mutant phenotype:GO:0018345 protein palmitoylation [PMID:15973437|PMID:16751107]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:18701706]" /experiment="EXISTENCE:mutant phenotype:GO:0030866 cortical actin cytoskeleton organization [PMID:18701706]" /note="Palmitoyltransferase that acts on transmembrane proteins; including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion" /db_xref="GeneID:851704" /db_xref="SGD:S000002533" ORIGIN 1 mswnllfvll igfvvlills pvfkstwpfs tfyrnvfqpf lvddqkyrwk lhlvplfyts 61 iylylvytyh mrvestikne lflleriliv piiilppval gilamvsrae dskdhksgst 121 eeypydylly ypaikcstcr ivkparskhc sicnrcvlva dhhciwinnc igkgnylqfy 181 lflisnifsm cyaflrlwyi slnststlpr avltltilcg cftiicaift ylqlaivkeg 241 mttneqdkwy tiqeymregk lvrsldddcp swffkcteqk ddaaeplqdq hvtfystnay 301 dhkhynlthy itikdaseip niydkgtfla nltdli // LOCUS NP_010412 1588 aa linear PLN 30-JUN-2025 DEFINITION pentafunctional protein ARO1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010412 VERSION NP_010412.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180435.1 REFERENCE 1 (residues 1 to 1588) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1588) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1588) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1588) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11973. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1588 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1588 /product="pentafunctional protein ARO1p" /EC_number="1.1.1.25" /EC_number="2.5.1.19" /EC_number="2.7.1.71" /EC_number="4.2.1.10" /EC_number="4.2.3.4" /calculated_mol_wt="174625" Region 13..399 /region_name="aroB" /note="3-dehydroquinate synthase; TIGR01357" /db_xref="CDD:273575" Site order(43,109..111,114,117,134..135,137,156,159,174,182,189, 193,279,283,295) /site_type="active" /db_xref="CDD:341474" Site order(83,90..91,118,121,123..125,147..148,157..162) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:341474" Site order(189,279,295) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:341474" Region 410..865 /region_name="EPSP_synthase" /note="EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); pfam00275" /db_xref="CDD:395213" Region 890..1047 /region_name="SK" /note="Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; cd00464" /db_xref="CDD:238260" Site order(898..903,1005,1012,1045) /site_type="other" /note="ADP binding site [chemical binding]" /db_xref="CDD:238260" Site order(902,918,920) /site_type="other" /note="magnesium binding site [ion binding]" /db_xref="CDD:238260" Site order(920,945,948,969..971,1026) /site_type="active" /note="putative shikimate binding site [active]" /db_xref="CDD:238260" Region 1076..1298 /region_name="aroD" /note="3-dehydroquinate dehydratase, type I; TIGR01093" /db_xref="CDD:273439" Site order(1080,1104,1106,1139,1198,1227,1266,1284..1285,1288) /site_type="active" /db_xref="CDD:188633" Site 1227 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:188633" Region 1302..1585 /region_name="Shik-DH-AROM" /note="shikimate-5-dehydrogenase, fungal AROM-type; TIGR01809" /db_xref="CDD:273813" CDS 1..1588 /gene="ARO1" /locus_tag="YDR127W" /coded_by="NM_001180435.1:1..4767" /experiment="EXISTENCE:direct assay:GO:0003855 3-dehydroquinate dehydratase activity [PMID:6355828]" /experiment="EXISTENCE:direct assay:GO:0003856 3-dehydroquinate synthase activity [PMID:6355828]" /experiment="EXISTENCE:direct assay:GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity [PMID:6355828]" /experiment="EXISTENCE:direct assay:GO:0004764 shikimate 3-dehydrogenase (NADP+) activity [PMID:6355828]" /experiment="EXISTENCE:direct assay:GO:0004765 shikimate kinase activity [PMID:6355828]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Pentafunctional arom protein; catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids" /db_xref="GeneID:851705" /db_xref="SGD:S000002534" ORIGIN 1 mvqlakvpil gndiihvgyn ihdhlvetii khcpsstyvi cndtnlskvp yyqqlvlefk 61 aslpegsrll tyvvkpgets ksretkaqle dyllvegctr dtvmvaiggg vigdmigfva 121 stfmrgvrvv qvptsllamv dssiggktai dtplgknfig afwqpkfvlv dikwletlak 181 refingmaev iktaciwnad eftrlesnas lflnvvngak nvkvtnqltn eideisntdi 241 eamldhtykl vlesikvkae vvssderess lrnllnfghs ighayeailt pqalhgecvs 301 igmvkeaels ryfgilsptq varlskilva yglpvspdek wfkeltlhkk tpldillkkm 361 sidkknegsk kkvvilesig kcygdsaqfv sdedlrfilt detlvypfkd ipadqqkvvi 421 ppgsksisnr alilaalgeg qckiknllhs ddtkhmltav helkgatisw edngetvvve 481 ghggstlsac adplylgnag tasrfltsla alvnstssqk yivltgnarm qqrpiaplvd 541 slrangtkie ylnnegslpi kvytdsvfkg grielaatvs sqyvssilmc apyaeepvtl 601 alvggkpisk lyvdmtikmm ekfginvets ttepytyyip kghyinpsey viesdassat 661 yplafaamtg ttvtvpnigf eslqgdarfa rdvlkpmgck itqtatsttv sgppvgtlkp 721 lkhvdmepmt dafltacvva aishdsdpns antttiegia nqrvkecnri lamatelakf 781 gvkttelpdg iqvhglnsik dlkvpsdssg pvgvctyddh rvamsfslla gmvnsqnerd 841 evanpvrile rhctgktwpg wwdvlhselg akldgaeple ctskknskks vviigmraag 901 kttiskwcas algyklvdld elfeqqhnnq svkqfvveng wekfreeetr ifkeviqnyg 961 ddgyvfstgg givesaesrk alkdfassgg yvlhlhrdie etivflqsdp srpayveeir 1021 evwnrregwy kecsnfsffa phcsaeaefq alrrsfskyi atitgvreie ipsgrsafvc 1081 ltfddlteqt enltpicygc eavevrvdhl anysadfvsk qlsilrkatd sipiiftvrt 1141 mkqggnfpde efktlrelyd ialkngvefl dleltlptdi qyevinkrgn tkiigshhdf 1201 qglyswddae wenrfnqalt ldvdvvkfvg tavnfednlr lehfrdthkn kpliavnmts 1261 kgsisrvlnn vltpvtsdll pnsaapgqlt vaqinkmyts mggiepkelf vvgkpighsr 1321 spilhntgye ilglphkfdk fetesaqlvk eklldgnknf ggaavtiplk ldimqymdel 1381 tdaakvigav ntviplgnkk fkgdntdwlg irnalinngv peyvghtagl vigaggtsra 1441 alyalhslgc kkifiinrtt sklkpliesl psefniigie stksieeike hvgvavscvp 1501 adkplddell sklerflvkg ahaafvptll eaaykpsvtp vmtisqdkyq whvvpgsqml 1561 vhqgvaqfek wtgfkgpfka ifdavtke // LOCUS NP_010413 1148 aa linear PLN 30-JUN-2025 DEFINITION Mtc5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010413 VERSION NP_010413.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180436.3 REFERENCE 1 (residues 1 to 1148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1148) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11974. On Jul 30, 2012 this sequence version replaced NP_010413.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1148 /product="Mtc5p" /calculated_mol_wt="130816" Region <24..342 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 29..63 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 71..112 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 117..154 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 162..198 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 204..245 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 248..298 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 304..338 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 433..543 /region_name="RWD" /note="domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain; smart00591" /db_xref="CDD:214735" Region 1092..1147 /region_name="zf-RING_16" /note="RING/Ubox like zinc-binding domain; pfam17120" /db_xref="CDD:375001" CDS 1..1148 /gene="MTC5" /locus_tag="YDR128W" /gene_synonym="SEA3" /coded_by="NM_001180436.3:1..3447" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]" /experiment="EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:23716719]" /note="Subunit of SEACAT, a subcomplex of the SEA complex; Mtc1p, along with Rtc1p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; relative distribution to the vacuolar membrane decreases upon DNA replication stress" /db_xref="GeneID:851706" /db_xref="SGD:S000002535" ORIGIN 1 mcssinegpy nsptfgksls lkvdggfnav sinpsgrdiv lasrqglyii dlddpftppr 61 wlhhitpwqv advqwsphpa kpywivstsn qkaiiwnlak sssnaiefvl hghsraitdi 121 nfnpqhpdvl atcsvdtyvh awdmrsphrp fystsswrsa asqvkwnykd pnvlasshgn 181 difvwdlrkg stplcslkgh vssvnsidfn rfkyseimss sndgtvkfwd yskstteskr 241 tvttnfpiwr grylpfgegy cimpmvggnn avylinlcdd ddseqnkktk lqpiyafkgh 301 sdrvidflwr srhtcdgdyd drefqlvtws kdcdlklwpi sdsiygkvnf drgkrleekl 361 pdydycsynk epenrenvqk nefrrlrenf vttsglkknk tnhitwlsgi rmnsatsqed 421 lfnetkiqnl geevsaighk fpkvvfekis vstrelcltl ngpwseenpd dyiflrisin 481 fplnypnkgd ppkftieens nltmskrqei lsnlatigqk ytdsnlycle pcirfvlgek 541 vsledieegq epllnfdiad hidfeelssl dssysdsqnp enlssqsdie sykealvfpd 601 tsnqgldfgr nlaldttpvp ngcgscwtat gelfcffane kkpekkqnai iklsqkeagv 661 ekhpfkiepq vlydkevdss vitaadelka rpkryvdtlg lgggtngdsr tyfddetssd 721 dsfdsvaddw ddilrndiiv rtkipilrgn fkafssvhse sgktvestkk nknlvisknf 781 ssllsdrkel aleylfmdat pegfarnnal vaekfdldei shcwqilsdm lidqsdydpy 841 ttiwnnhpmg ikwfikeaiv yferqqnlqm lamlccvils arrkkipary ygqelenmeg 901 tivfndnesq ntsfwkgsda fstrsrsstv tpnfygnhlr gknihggdns sirsddhhar 961 lrthntlngs skftepaqkq gsraissspf hsrmpdikve llhddiieay eqedllhlev 1021 sdipkfqtyi yqyskllfrw glplervkil kvstdfrssy ssqgippnnn kkspyngvlt 1081 hwiennefge ekflarncny cdlrvtrssf icgncqhvlh sscariwwei gdecpsgcgc 1141 ncpemfda // LOCUS NP_010414 642 aa linear PLN 30-JUN-2025 DEFINITION fimbrin [Saccharomyces cerevisiae S288C]. ACCESSION NP_010414 VERSION NP_010414.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180437.3 REFERENCE 1 (residues 1 to 642) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 642) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 642) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 642) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11975. On Jul 30, 2012 this sequence version replaced NP_010414.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..642 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..642 /product="fimbrin" /calculated_mol_wt="71642" Region 1..640 /region_name="SAC6" /note="Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]; COG5069" /db_xref="CDD:227401" CDS 1..642 /gene="SAC6" /locus_tag="YDR129C" /gene_synonym="ABP67" /coded_by="NM_001180437.3:1..1929" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:3060468]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:12857851]" /experiment="EXISTENCE:direct assay:GO:0032432 actin filament bundle [PMID:3060468]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:2643162|PMID:3060468]" /experiment="EXISTENCE:genetic interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:27068241]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:8522605]" /experiment="EXISTENCE:mutant phenotype:GO:0070649 formin-nucleated actin cable assembly [PMID:27068241]" /note="Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant" /db_xref="GeneID:851707" /db_xref="SGD:S000002536" ORIGIN 1 mnivklqrkf piltqedlfs tiekfraidl ddkgwvekqq aleavskdgd atydearetl 61 khvgvdasgr velddyvglv aklresktga apqttfnvap nstpivstaa tglqhkgkgt 121 qakiivagsq tgtthtinee erreftkhin svlagdqdig dllpfptdtf qlfdecrdgl 181 vlsklindsv pdtidtrvln wpkkgkelnn fqasenaniv insakaigcv vvnvhsedii 241 egrehlilgl iwqiirrgll skidiklhpe lyrlleddet leqflrlppe qillrwfnyh 301 lkqanwnrrv tnfskdvsdg enytillnql dpalcskapl qttdlmerae qvlqnaekld 361 crkyltpssl vagnpklnla fvahlfnthp glepiqeeek peieefdaeg erearvftlw 421 lnsldvdppv islfddlkdg lillqayekv mpgavdfkhv nkrpasgaei srfkalentn 481 yavdlgrakg fslvgiegsd ivdgnklltl glvwqlmrrn isitmktlss sgrdmsdsqi 541 lkwaqdqvtk ggknstirsf kdqalsnahf lldvlngiap gyvdydlvtp gnteeeryan 601 arlaisiark lgaliwlvpe dinevrarli itfiaslmtl nk // LOCUS NP_010415 291 aa linear PLN 30-JUN-2025 DEFINITION Fin1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010415 VERSION NP_010415.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180438.1 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11976. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..291 /product="Fin1p" /calculated_mol_wt="33055" Region 15..283 /region_name="FIN1" /note="Filaments in between nuclei protein-1; pfam17300" /db_xref="CDD:407411" CDS 1..291 /gene="FIN1" /locus_tag="YDR130C" /coded_by="NM_001180438.1:1..876" /experiment="EXISTENCE:direct assay:GO:0000235 astral microtubule [PMID:17173039]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:19948764]" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:11929974]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17173039|PMID:11929974]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:17804403|PMID:11929974|PMID:17173039|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:17804403]" /experiment="EXISTENCE:direct assay:GO:0005882 intermediate filament [PMID:11929974]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:17173039]" /experiment="EXISTENCE:direct assay:GO:0045104 intermediate filament cytoskeleton organization [PMID:12551942]" /experiment="EXISTENCE:direct assay:GO:0072686 mitotic spindle [PMID:11929974|PMID:17173039]" /experiment="EXISTENCE:genetic interaction:GO:1902426 deactivation of mitotic spindle assembly checkpoint [PMID:19948764]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:17173039]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:17804403|PMID:17173039]" /experiment="EXISTENCE:mutant phenotype:GO:0008017 microtubule binding [PMID:17804403]" /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:19948764]" /experiment="EXISTENCE:mutant phenotype:GO:1902426 deactivation of mitotic spindle assembly checkpoint [PMID:19948764]" /experiment="EXISTENCE:physical interaction:GO:0000164 protein phosphatase type 1 complex [PMID:19948764]" /note="Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:851708" /db_xref="SGD:S000002537" ORIGIN 1 msnksnrrsl rdigntigrn nipsdkdnvf vrlsmsplrt tsqkeflkpp mrispnktdg 61 mkhsiqvtpr rimspeclkg yvsketqsld rpqfknsnkn vkiqnsdhit niifptsptk 121 ltfsnenkig gdgsltrira rfknglmspe riqqqqqqhi lpsdaksntd lcsntelkda 181 pfendlprak lkgknllvel kkeeedvgng iesltksntk lnsmlanegk ihkasfqksv 241 kfklpdnivt eetvelkeik dlllqmlrrq reiesrlsni elqlteipkh k // LOCUS NP_010416 556 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR131C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010416 VERSION NP_010416.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180439.1 REFERENCE 1 (residues 1 to 556) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 556) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 556) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 556) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11977. Method: conceptual translation. FEATURES Location/Qualifiers source 1..556 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..556 /product="uncharacterized protein" /calculated_mol_wt="65112" Region 2..44 /region_name="F-box_SF" /note="F-box domain superfamily; cl45894" /db_xref="CDD:459239" Site order(5..6,8..10,13..14,17,28..30,32,35) /site_type="other" /note="F-box motif" /db_xref="CDD:438852" Site order(5,9,12..13,16..17,21,23..24,28..30,32) /site_type="other" /note="Skp1 binding site [polypeptide binding]" /db_xref="CDD:438852" CDS 1..556 /locus_tag="YDR131C" /coded_by="NM_001180439.1:1..1671" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994|PMID:10582239]" /experiment="EXISTENCE:direct assay:GO:0031625 ubiquitin protein ligase binding [PMID:21186364]" /experiment="EXISTENCE:genetic interaction:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:10582239]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /note="F-box protein subunit of SCF ubiquitin ligase complex; substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex" /db_xref="GeneID:851709" /db_xref="SGD:S000002538" ORIGIN 1 mfdklpyeif kqiawripqe dkisltyvck rsyesiipfi yqnlflnety hingdydnsf 61 gtcywsvlnf hyideddsnt kndmsnrrla kvkfsyfert laespkrlcp linrirctwh 121 lnedvmtnvl kllseygsnl kfvdqfvrss vnkgleplsk qlktltltpp tlmpthnsvs 181 gsylnkidrl llkcdlsrle klsihinalk yfkntgspmk ikalvlnlrp dtlnlaeyda 241 sddflkeley idifdastlr qleilswysr ddfpsgeegg fdrlyvkwgl egfwkfpnie 301 klslaslvys efflmnclav fhnlkilkld ymgkfdfdvs linflskqvc gkklqrfdih 361 cqlnhrlffp mtdnpltrln fdgfcpcstc kntihevilk kifpetrskl lknpnkfqah 421 nffyqmffen kimpytniid nespamgwds vpietfvrkf nenlqstien tenitvnkit 481 redaislyhl ylhylkdvfk vfeqslpnle yltingiptk iiqvdelqrc avplfynngy 541 ksnsvyelvd aealfs // LOCUS NP_010417 495 aa linear PLN 30-JUN-2025 DEFINITION Mrx16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010417 VERSION NP_010417.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180440.3 REFERENCE 1 (residues 1 to 495) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 495) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 495) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 495) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11978. On Jul 30, 2012 this sequence version replaced NP_010417.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..495 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..495 /product="Mrx16p" /calculated_mol_wt="57063" Region 30..121 /region_name="BTB_POZ_KCTD-like" /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; cd18316" /db_xref="CDD:349625" CDS 1..495 /gene="MRX16" /locus_tag="YDR132C" /coded_by="NM_001180440.3:1..1488" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22842922]" /note="Protein that associates with the large mitoribosomal subunit; abundance and relative nuclear distribution to the protein increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication" /db_xref="GeneID:851710" /db_xref="SGD:S000002539" ORIGIN 1 msnsptvatl sqeyfdpnip qilphekmyk iqvgkslfki sgaslssdgp sffteyfskk 61 rspsnnddsn ndtmesnkne vlfidrsaev fewiyqhlqg yiieikdevq ytmlfadamy 121 ynlprlrsll ketdyyftni ggqsfkiakn lfrregdspn yfeiyaatvy idveeliisk 181 kllrppshsa pyiprsseyf kdlltllgga sidlddnkrn alikecryyr llnleqrlik 241 shisynpitr keeiclllkd lskkgitfpa ssafstspyf eddfcsinec dslsktreqp 301 ankkikldmt ekyndswnml cykrpfldkh prelifqins tdctiilnke sqsihvditg 361 esaykfealf gshlpntpsg apklknyqyr fpsdstqtki ethyllpaci ylcdldingi 421 kisqvqtllt dknkfndrvi dvsdpldlrf csglklylrk slwklavkdg nimliaikai 481 afngtkeyyk gyeyl // LOCUS NP_010419 1515 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette glutathione S-conjugate transporter YCF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010419 VERSION NP_010419.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180442.3 REFERENCE 1 (residues 1 to 1515) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1515) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1515) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1515) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11979. On Jul 30, 2012 this sequence version replaced NP_010419.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1515 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1515 /product="ATP-binding cassette glutathione S-conjugate transporter YCF1" /EC_number="7.2.2.2" /EC_number="7.6.2.3" /calculated_mol_wt="170991" Region 27..1511 /region_name="MRP_assoc_pro" /note="multi drug resistance-associated protein (MRP); TIGR00957" /db_xref="CDD:188098" CDS 1..1515 /gene="YCF1" /locus_tag="YDR135C" /coded_by="NM_001180442.3:1..4548" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:8692889|PMID:23658021|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010038 response to metal ion [PMID:10220408|PMID:9217966|PMID:12755704]" /experiment="EXISTENCE:direct assay:GO:0015431 ABC-type glutathione S-conjugate transporter activity [PMID:10220408|PMID:12383937|PMID:9217966|PMID:12755704]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:genetic interaction:GO:0006749 glutathione metabolic process [PMID:23242256]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:23658021]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:23242256]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:10790694]" /note="Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR" /db_xref="GeneID:851713" /db_xref="SGD:S000002542" ORIGIN 1 magnlvswac klcrspegfg pisfygdftq cfidgvilnl saifmitfgi rdlvnlckkk 61 hsgikyrrnw iivsrmalvl leiafvslas lniskeeaen ftivsqyast mlslfvalal 121 hwieydrsvv antvllfywl fetfgnfakl inilirhtye giwysgqtgf iltlfqvitc 181 asilllealp kkplmphqhi hqtltrrkpn pydsanifsr itfswmsglm ktgyekylve 241 adlyklprnf sseelsqkle knwenelkqk snpslswaic rtfgskmlla affkaihdvl 301 aftqpqllri likfvtdyns erqddhsslq gfennhpqkl pivrgfliaf amflvgftqt 361 svlhqyflnv fntgmyiksa ltaliyqksl vlsneasgls stgdivnlms vdvqklqdlt 421 qwlnliwsgp fqiiiclysl ykllgnsmwv gviilvimmp lnsflmriqk klqksqmkyk 481 dertrvisei lnnikslkly awekpyrekl eevrnnkelk nltklgcyma vtsfqfnivp 541 flvscctfav fvytedralt tdlvfpaltl fnllsfplmi ipmvlnsfie asvsigrlft 601 fftneelqpd svqrlpkvkn igdvainigd datflwqrkp eykvalknin fqakkgnltc 661 ivgkvgsgkt allscmlgdl frvkgfatvh gsvayvsqvp wimngtvken ilfghrydae 721 fyektikaca ltidlailmd gdktlvgekg islsggqkar lslaravyar adtyllddpl 781 aavdehvarh liehvlgpng llhtktkvla tnkvsalsia dsialldnge itqqgtydei 841 tkdadsplwk llnnygkknn gksnefgdss essvressip vegeleqlqk lndldfgnsd 901 aislrrasda tlgsidfgdd eniakrehre qgkvkwniyl eyakacnpks vcvfilfivi 961 smflsvmgnv wlkhwsevns rygsnpnaar ylaiyfalgi gsalatliqt ivlwvfctih 1021 askylhnlmt nsvlrapmtf fettpigril nrfsndiykv dallgrtfsq ffvnavkvtf 1081 titvicattw qfifiiipls vfyiyyqqyy lrtsrelrrl dsitrspiys hfqetlggla 1141 tvrgysqqkr fshinqcrid nnmsafypsi nanrwlayrl eligsiiilg aatlsvfrlk 1201 qgtltagmvg lslsyalqit qtlnwivrmt vevetnivsv erikeyadlk seaplivegh 1261 rppkewpsqg dikfnnystr yrpeldlvlk hinihikpne kvgivgrtga gkssltlalf 1321 rmieasegni vidniainei glydlrhkls iipqdsqvfe gtvrenidpi nqytdeaiwr 1381 alelshlkeh vlsmsndgld aqltegggnl svgqrqllcl aramlvpski lvldeataav 1441 dvetdkvvqe tirtafkdrt iltiahrlnt imdsdriivl dngkvaefds pgqllsdnks 1501 lfyslcmeag lvnen // LOCUS NP_010421 663 aa linear PLN 30-JUN-2025 DEFINITION Rgp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010421 VERSION NP_010421.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180444.1 REFERENCE 1 (residues 1 to 663) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 663) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 663) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 663) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11980. Method: conceptual translation. FEATURES Location/Qualifiers source 1..663 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..663 /product="Rgp1p" /calculated_mol_wt="75187" Region 132..614 /region_name="Rgp1" /note="pfam08737" /db_xref="CDD:430181" CDS 1..663 /gene="RGP1" /locus_tag="YDR137W" /coded_by="NM_001180444.1:1..1992" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10990452]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:10990452]" /experiment="EXISTENCE:direct assay:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:10990452]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:11082047]" /experiment="EXISTENCE:physical interaction:GO:0000139 Golgi membrane [PMID:10990452]" /experiment="EXISTENCE:physical interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10990452]" /experiment="EXISTENCE:physical interaction:GO:0034066 Ric1-Rgp1 guanyl-nucleotide exchange factor complex [PMID:10990452]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:10990452]" /note="Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p); this complex catalyzes nucleotide exchange on Ypt6p" /db_xref="GeneID:851714" /db_xref="SGD:S000002544" ORIGIN 1 mrahridtfl irenikleii hesnsyfgge hisiafrfkh lgsqhelfny keklltvdka 61 veekleqqak vqddgegtme nqtwslksll gafkrtgepe esvdvdnmkm lneskmlrek 121 iqkqmyfhqp vtlisgyvqi sgvfqydsev iseskfkqde vkmvgldivp ghttnsvlal 181 edgehfkgkr nltnylnsdy tnvtngllfs esgsrgrtgt ynertlmisn dtsiktlpll 241 lipqtllfse islepgevrt fyfkstklpk dicpsysssk vasinytlev gadvlsddni 301 ekfsnrvpit iapyissnae qytsrldkpa iilktgnike lkprlftrkv stasavsfgr 361 rkssiidids plednefvkr vkknfielve snqnvsrdid elidlqmgvq fgkdedssdp 421 epndshfsne mvtsaesslr sdavtkrrks ysvrdnisnl eqkmwndcsl vksdensnll 481 pqlinlqnay qinrnnetma kvslsapfyk ttddinlvie ldpittpllk vtsltvsles 541 feiinpkykt egkgigskpk gnsvyekhfi cfdecksvsv kllpprsptn qitgqfktdv 601 fqhkwmiglk fviiaktesi tldqfyedkk gilfhskenl egeeftcyvp ipilctsedf 661 mgw // LOCUS NP_010422 752 aa linear PLN 30-JUN-2025 DEFINITION Hpr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010422 VERSION NP_010422.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180445.1 REFERENCE 1 (residues 1 to 752) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 752) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 752) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 752) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11981. Method: conceptual translation. FEATURES Location/Qualifiers source 1..752 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..752 /product="Hpr1p" /calculated_mol_wt="87698" Region 100..614 /region_name="efThoc1" /note="THO complex subunit 1 transcription elongation factor; pfam11957" /db_xref="CDD:463412" Region 606..>738 /region_name="DUF612" /note="Protein of unknown function, DUF612; pfam04747" /db_xref="CDD:282585" CDS 1..752 /gene="HPR1" /locus_tag="YDR138W" /gene_synonym="TRF1" /coded_by="NM_001180445.1:1..2259" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:24084588]" /experiment="EXISTENCE:direct assay:GO:0003676 nucleic acid binding [PMID:12093753]" /experiment="EXISTENCE:mutant phenotype:GO:0000445 THO complex part of transcription export complex [PMID:11979277]" /experiment="EXISTENCE:mutant phenotype:GO:0000446 nucleoplasmic THO complex [PMID:11060033]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:3044923|PMID:11060033]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:12093753|PMID:17960421]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:11979277]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:18614048]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:26663077]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:16908536]" /experiment="EXISTENCE:mutant phenotype:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:26663077]" /experiment="EXISTENCE:physical interaction:GO:0016593 Cdc73/Paf1 complex [PMID:9891041]" /note="Subunit of THO/TREX complexes; this complex couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p" /db_xref="GeneID:851716" /db_xref="SGD:S000002545" ORIGIN 1 msnteeliqn sigflqktfk alpvsfdsir heplpssmlh asvlnfewep leknisaihd 61 rdslidiilk rfiidsmtna iedeeennle kgllnscigl dfvynsrfnr snpaswgntf 121 felfstiidl lnspstflkf wpyaesriew fkmntsvepv slgesnlisy kqplyeklrh 181 wndilaklen ndilntvkhy nmkyklenfl sellpinees nfnrsasisa lqesdnewnr 241 sareresnrs sdvifaadyn fvfyhliicp iefafsdley kndvdrslsp lldaileiee 301 nfyskikmnn rtrysleeal nteyyanydv mtpklpvymk hsnamkmdrn efwanlqnik 361 esddytlrpt imdislsntt clykqltqed ddyyrkqfil qlcfttnlir nlissdetrn 421 fykscylren plsdidfenl devnkkrgln lcsyicdnrv lkfykikdpd fyrvirklms 481 sdekfttaki dgfkefqnfr iskekipppa fdetfkkftf ikmgnklinn vwkiptgldk 541 ieqevkkpeg vyeaaqakwe skissetsgg eakdeiirqw qtlrflrsry lfdfdkvnek 601 tgvdglfeep rkvealddsf kekllykinq ehrkklqdar eykigkerkk raleeeasfp 661 ereqkiksqr insasqtegd elkseqtqpk geiseentki kssevssqdp dsgvagefap 721 qnttaqlenp ktednnaats nisngsstqd mk // LOCUS NP_010423 77 aa linear PLN 30-JUN-2025 DEFINITION NEDD8 family protein RUB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010423 VERSION NP_010423.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180446.3 REFERENCE 1 (residues 1 to 77) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 77) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 77) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 77) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11982. On Jul 30, 2012 this sequence version replaced NP_010423.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..77 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..77 /product="NEDD8 family protein RUB1" /calculated_mol_wt="8562" Region 3..76 /region_name="Ubl_NEDD8" /note="ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins; cd01806" /db_xref="CDD:340504" Site order(6..10,28..29,31..32,34..37,40,42,44,47..49,68,70..76) /site_type="other" /note="E1/E2/E3 interaction site [polypeptide binding]" /db_xref="CDD:340504" Site order(6,8..9,40,42,44..54,59,68,70..76) /site_type="other" /note="NEDP1 interaction site [polypeptide binding]" /db_xref="CDD:340504" Site order(6..11,31..37,39..40,47,68,70..74) /site_type="other" /note="bacterial deamidase effectors interaction site [polypeptide binding]" /db_xref="CDD:340504" Site order(6,11,27,29,48) /site_type="other" /note="key conserved lysines" /db_xref="CDD:340504" CDS 1..77 /gene="RUB1" /locus_tag="YDR139C" /coded_by="NM_001180446.3:1..234" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031386 protein tag activity [PMID:9545234|PMID:9531531]" /experiment="EXISTENCE:direct assay:GO:0045116 protein neddylation [PMID:9545234|PMID:9531531]" /experiment="EXISTENCE:genetic interaction:GO:0045116 protein neddylation [PMID:9531531]" /note="Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme)" /db_xref="GeneID:851717" /db_xref="SGD:S000002546" ORIGIN 1 mivkvktltg keisvelkes dlvyhikell eekegippsq qrlifqgkqi ddkltvtdah 61 lvegmqlhlv ltlrggn // LOCUS NP_010424 221 aa linear PLN 30-JUN-2025 DEFINITION S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010424 VERSION NP_010424.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180447.3 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11983. On Jul 30, 2012 this sequence version replaced NP_010424.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..221 /product="S-adenosylmethionine-dependent methyltransferase" /EC_number="2.1.1.297" /calculated_mol_wt="24842" Region 12..221 /region_name="AdoMet_MTases" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl17173" /db_xref="CDD:473071" Site order(49..55,77..78,105..107,122) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..221 /gene="MTQ2" /locus_tag="YDR140W" /coded_by="NM_001180447.3:1..666" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006417 regulation of translation [PMID:15509572|PMID:16321977]" /experiment="EXISTENCE:direct assay:GO:0008276 protein methyltransferase activity [PMID:17008308|PMID:15509572]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:16321977]" /experiment="EXISTENCE:direct assay:GO:0015934 large ribosomal subunit [PMID:33166396]" /experiment="EXISTENCE:direct assay:GO:0018364 peptidyl-glutamine methylation [PMID:17008308|PMID:15509572]" /experiment="EXISTENCE:mutant phenotype:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:33166396|PMID:16321977]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:33166396]" /experiment="EXISTENCE:physical interaction:GO:0035657 eRF1 methyltransferase complex [PMID:17008308]" /note="S-adenosylmethionine-dependent methyltransferase; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC; member of the seven beta-strand family" /db_xref="GeneID:851718" /db_xref="SGD:S000002547" ORIGIN 1 mlptpyvkcd ydkvyepaed sflildclek ehdflkqkfg nrlaivceig sgsgivttfl 61 mqnkiipqen sihlavdinp waleatldta klnsckssfl eviqadlnss irnnqvdvli 121 fnppyvpaec vpdvpgsree adqwldlall ggkdgmaitd kllrqleqil spdgvayilf 181 carnkpkevi krfvdtykwn vklietrkag wevlsvysft r // LOCUS NP_010425 1698 aa linear PLN 30-JUN-2025 DEFINITION Dop1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010425 VERSION NP_010425.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180448.1 REFERENCE 1 (residues 1 to 1698) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1698) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1698) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1698) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11984. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1698 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1698 /product="Dop1p" /calculated_mol_wt="194557" Region 6..1698 /region_name="DOP1" /note="Dopey and related predicted leucine zipper transcription factors [Transcription]; COG5221" /db_xref="CDD:227546" CDS 1..1698 /gene="DOP1" /locus_tag="YDR141C" /coded_by="NM_001180448.1:1..5097" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:20477991]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16301316|PMID:30981741]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000301 retrograde transport, vesicle recycling within Golgi [PMID:30981741]" /experiment="EXISTENCE:mutant phenotype:GO:0000902 cell morphogenesis [PMID:10931277]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:16301316]" /note="Protein involved in vesicular transport at trans-Golgi network (TGN); TGN-localized, leucine-zipper domain protein; involved in endosome-to-Golgi transport during endocytic recycling, and retrograde transport of glycosyltransferases from the TGN to the Golgi; involved in organization of the ER, establishment of cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:851719" /db_xref="SGD:S000002548" ORIGIN 1 mslplkplti dsnnkqldsk qkkfranver alerfdsvte wadyiaslgt llkalqswsp 61 kfqnvryyvp spyqvsrrlt sslspalpag vhqktlevyt yifehiglet latecniwip 121 gilplmtyas msvrshliel ydnyilllpq ttlrllirpl issllpgidd esndflpltl 181 klietlqenl dddslfwqtl flvmtankgr rlggltwltr kfpslnavph lvnkikmeae 241 enpsetetnd shldrkkrke eafkvllpaa kdlvtpepgl lirclvgcle dendilikrs 301 vldlllqrlr ldspvlnvli tsedkkllim sccrttlskd mslnrriwnw llgptaggml 361 nnnggnsmey ttsvksanee snvyftkygl salleglsdl lseeesvlta frismavmdr 421 weigslvipe lfipllysse kfkqneqimk tartffdnte tniiwgklfq elediknlki 481 ldfvltnfni gndeeiivrh lplilltlla lpsndkdfdn iyklqkfsly nkllnyiper 541 allplshskl khddevscee llakirgfyt nvsnpssile keniaerlpp fttedltfli 601 adliqkklls slwdlenine ssklfiaife kipeseelkg rshiswsdkk itqsifeaip 661 rlcesnndak seeivgivei fgnylysrme fiesmkllkv vmmavwkslk dprhqilgvk 721 nlktlnrfip skfiesalvy tfveeedise rlsvldllwt qldsdsnlir rplelilgel 781 fddqnpfylt vskwilsiln sgsasrlfyi ltdnilkvnr lekerlderd dldmltyefq 841 mlayvlktnn grtrkvfste ltsiksstiw knedvstyks lllvtlmrfl niksnthaks 901 irsalilldi lldgteqnfk divifllqms skyiaeegie peliavslld ivskvlrlsh 961 dngikldifd dnaahlkyid flvtsvsnmk splivtayvk llsesivyfe nsifrmilpl 1021 saslvqcvqr lfllekregg yyqpialllg gleelleish gylvteereg yfsgsnlkgd 1081 fiqsvvsnvf ssdssneesk iqgerdvilq sfrqvisccl diwywahnis cksnddssld 1141 atnhnsykfk frskklletl flleplelle nlisirsdnt tvtlvhvldg nkpaitiphl 1201 lygviirynr tasvkfsnrd gsrssttklt kgepsmlkrl sgesiiaflf nyvdsvensa 1261 meefygdfll ffrevatnyn lysdvslsil klvalisgkv sktqfgeqkr vrreisdvff 1321 kylpnafinf tnlyrghpds fkdlefvvwr vqyivndqig gdkfnttlat ivnqcltpyi 1381 kpksektipg yvlelaavvs hlgskvkswr lliaelfqnd kklsvigsdq twekiiyews 1441 iypenkskil ndllleigsk rssvtptlit fnlgsdseve ykcqnllkis yllmvspnda 1501 yllhfsslis cifhylvskd iklkgscwil lrvlllrfse shfndywsmi syclqtnlqe 1561 fyeslqiqse vdpqtilqvc ktldllllln megftstnew ifvidtincv yktnsfvalv 1621 deiaefkdye itktddlelp ttlkdglpll rgihkierht qlrsffqnls ylhyekvygl 1681 gsvdlygcge dlkkdils // LOCUS NP_010426 375 aa linear PLN 30-JUN-2025 DEFINITION Pex7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010426 VERSION NP_010426.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180449.1 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11985. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..375 /product="Pex7p" /calculated_mol_wt="42192" Region 11..55 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 65..102 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <71..372 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(78,82,88..89,102..103,121,126,132..133,170,191,196, 202..203,217..218,238,242,248..249,281..282,300,305, 311..312,340..341,361,365,371..372) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 107..144 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 152..214 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 221..270 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 286..339 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 345..371 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..375 /gene="PEX7" /locus_tag="YDR142C" /gene_synonym="PAS7; PEB1" /coded_by="NM_001180449.1:1..1128" /experiment="EXISTENCE:direct assay:GO:0005053 peroxisome matrix targeting signal-2 binding [PMID:8670791]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:15545321|PMID:7535304|PMID:7957058]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:7957058|PMID:15545321]" /experiment="EXISTENCE:physical interaction:GO:0005053 peroxisome matrix targeting signal-2 binding [PMID:8636211]" /experiment="EXISTENCE:physical interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:9094717|PMID:10087260]" /note="Peroxisomal signal receptor for peroxisomal matrix proteins; recognizes the N-terminal nonapeptide signal (PTS2); WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)" /db_xref="GeneID:851720" /db_xref="SGD:S000002549" ORIGIN 1 mlryhmqgfs gygvqyspff dnrlavaags nfglvgngkl fileidrsgr ivevnsfltq 61 dclfdlawne shenqvlvaq gdgtlrlfdt tfkefpiaif keherevfsc nwnlvnrqnf 121 lssswdgsik iwsplrkqsl mtltprplei tkmvdplnai ilkkksftgi sknrncvyqa 181 qfsphdqnlv lscsgnsyas lfdirlpsgk nqnnflvhsg lealtcdfnk yrpyvvatgg 241 vdnairiwdi rmlnknesat ikrtvpgqlh nsscineipn ahglairkvt wsphhsnilm 301 sasydmtcri wrdlsndgak etyktnstda tkgsifnftq hsefvfgadw slwgkpgyva 361 stawdgnlfv wnglg // LOCUS NP_010427 610 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein ligase SAN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010427 VERSION NP_010427.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180450.3 REFERENCE 1 (residues 1 to 610) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 610) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 610) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 610) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11986. On Jul 30, 2012 this sequence version replaced NP_010427.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..610 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..610 /product="ubiquitin-protein ligase SAN1" /calculated_mol_wt="65487" Region <242..424 /region_name="HRD1" /note="HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]; COG5243" /db_xref="CDD:227568" Region <250..286 /region_name="RING_Ubox" /note="RING finger (Really Interesting New Gene) domain and U-box domain superfamily; cl17238" /db_xref="CDD:473075" CDS 1..610 /gene="SAN1" /locus_tag="YDR143C" /coded_by="NM_001180450.3:1..1833" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:15078868|PMID:15797381]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15797381]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15078868|PMID:15797381]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:20080635]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15797381]" /experiment="EXISTENCE:mutant phenotype:GO:0051788 response to misfolded protein [PMID:15797381]" /experiment="EXISTENCE:mutant phenotype:GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system [PMID:20080635]" /note="Ubiquitin-protein ligase; role in proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity; contains intrinsically disordered regions involved in substrate recognition; prefers a window of exposed hydrophobicity that causes a particular level of protein insolubility, suggesting that San1p evolved to target highly aggregation-prone proteins; localizes to the cytoplasm, nucleus and peroxisomes" /db_xref="GeneID:851721" /db_xref="SGD:S000002550" ORIGIN 1 msesgqeqnr gtntspnnae nnnnsnaasg plnggaeqtr nitvsiqysy ftperlahls 61 nisnndnnen nsaasgstia ngtgpsfgig ngghqpdgal vlsfrdvpas tpqdrlnsfi 121 svaaqlamer fnrllnrpkg iskdefdklp vlqvsdlpka egplcsicyd eyedevdstk 181 akrkrdsene eesegtkkrk dnegaplrtt adndsnpsit natvveppsi plteqqrtln 241 deetnpsykh spiklpcghi fgreciykws rlenscplcr qkisesvgvq raaqqdtdev 301 aaneaaferi rrvlydptav nstnenssap sentsnttvp tignassgeq mlsrtgfflv 361 pqngqplhnp vrlppndsdr ngvngpsstt qnppsnsggs nnnqsprwvp ipltlfqfhs 421 pnpnpsasds saspsaangp nsnntssdat dphhnrlrav ldhifnvaqr gtsdtsatta 481 pgaqtvhnqg rndssssdtt qgssflenis rltghftngs rdnnndnnhs ndqqrggstg 541 ennrnnlfss gvasyrnqng dvttvelrnn nsaafpptde npsqgqgsss sdttihndvp 601 ndnneqrssq // LOCUS NP_010428 596 aa linear PLN 30-JUN-2025 DEFINITION aspartyl protease [Saccharomyces cerevisiae S288C]. ACCESSION NP_010428 VERSION NP_010428.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180451.3 REFERENCE 1 (residues 1 to 596) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 596) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 596) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 596) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11987. On Jul 30, 2012 this sequence version replaced NP_010428.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..596 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..596 /product="aspartyl protease" /EC_number="3.4.23.41" /calculated_mol_wt="64138" Region 79..470 /region_name="SAP_like" /note="SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins; cd05474" /db_xref="CDD:133141" Site order(80,194,197,202,208,243,437,443) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:133141" Site order(99..102,360..363) /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:133141" Site order(99,360) /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:133141" Site order(195..200,202..206) /site_type="active" /note="Active site flap [active]" /db_xref="CDD:133141" CDS 1..596 /gene="MKC7" /locus_tag="YDR144C" /gene_synonym="YPS2" /coded_by="NM_001180451.3:1..1791" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004190 aspartic-type endopeptidase activity [PMID:10446224]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:16087741]" /experiment="EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:18591427]" /note="GPI-anchored aspartyl protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p; MKC7 has a paralog, YPS1, that arose from the whole genome duplication" /db_xref="GeneID:851722" /db_xref="SGD:S000002551" ORIGIN 1 mklsvltfvv dallvcssiv dagvtdfpsl psnevyvkmn fqkkygssfe nalddtkgrt 61 rlmtrdddye lveltnqnsf ysveldigtp pqkvtvlvdt gssdlwvtgs dnpycstkkk 121 dttgssfkqv nkdalasvve svfteisydt tivtseatat fdstastsql idcatygtfn 181 tsksstfnsn ntefsiaygd ttfasgtwgh dqlslndlni tglsfavane tnstvgvlgi 241 glpglestys gvslssvqks ytynnfpmvl knsgviksta yslfandsds khgtilfgav 301 dhgkyagdly tipiintlqh rgykdpiqfq vtlqglgtsk gdkednlttl tttkipvlld 361 sgttisympt elvkmladqv gatyssaygy yimdcikeme eessiifdfg gfylsnwlsd 421 fqlvtdsrsn icilgiapqs dptiilgdnf lantyvvydl dnmeismaqa nfsddgeyie 481 iiesavpsal kapgysstws tyesivsggn mfstaanssi syfastshsa tssssskgqk 541 tqtsttalsi skstsstsst gmlsptssss trkengghnl nppffarfit aifhhi // LOCUS NP_010429 539 aa linear PLN 30-JUN-2025 DEFINITION Taf12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010429 VERSION NP_010429.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180452.1 REFERENCE 1 (residues 1 to 539) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 539) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 539) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 539) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11988. Method: conceptual translation. FEATURES Location/Qualifiers source 1..539 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..539 /product="Taf12p" /calculated_mol_wt="60942" Region 1..539 /region_name="COG5624" /note="Transcription initiation factor TFIID, subunit TAF12 [Transcription]" /db_xref="CDD:227911" Site order(412..415,419,423,426..427,446,449..451,453..455, 458..459,462,465,473..475,478..479,482,486,488,490) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467025" Site order(438,442,446,467..469,480,484) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467025" CDS 1..539 /gene="TAF12" /locus_tag="YDR145W" /gene_synonym="TAF61; TAF68" /coded_by="NM_001180452.1:1..1620" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10817999|PMID:12600943]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:10751405]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:12582246|PMID:11561287|PMID:10751405]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12600943|PMID:12840001]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:9674426]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]" /note="Subunit (61/68 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A; overexpression of the human ortholog, TAF12, an oncogene involved in the formation of choroid plexus carcinomas, results in dosage chromosomal instability (dCIN) in a human cell line similar to the dCIN observed in yeast overexpressors" /db_xref="GeneID:851723" /db_xref="SGD:S000002552" ORIGIN 1 mssnpensgv nannntgtgn adaitgaqqn mvlqprqlqe maakfrtllt earnvgettp 61 rgkelmfqaa kikqvydalt lnrrrqqaaq aynntsnsns snpasipten vpnssqqqqq 121 qqqqtrnnsn kfsnmikqvl tpeenqeyek lwqnfqvrht sikeketylk qnidrleqei 181 nkqtdegpkq qlqekkiell ndwkvlkiey tklfnnyqns kktfyvecar hnpalhkflq 241 estqqqrvqq qrvqqqqqqq qqqqqqqqqq qqqqqqrqgq nqrkisssns teipsvtgpd 301 alksqqqqqn titatnnprg nvntsqteqs kakvtnvnat asmlnnisss ksaifkqtep 361 aipisenist ktpapvayrs nrptitggsa mnasalntpa ttklppyemd tqrvmskrkl 421 relvktvgid egdgetvidg dveellldla ddfvtnvtaf scrlakhrks dnleardiql 481 hlernwniri pgysadeirs trkwnpsqny nqklqsitsd kvaaaknngn nvaslntkk // LOCUS NP_010430 709 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcription factor SWI5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010430 VERSION NP_010430.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180453.1 REFERENCE 1 (residues 1 to 709) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 709) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 709) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 709) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11989. Method: conceptual translation. FEATURES Location/Qualifiers source 1..709 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..709 /product="DNA-binding transcription factor SWI5" /calculated_mol_wt="79644" Region 124..630 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 552..574 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(552,557,570,574) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Site order(559,561,563,565..566,569..570,573,589,591,595..596, 599..600,603,615,617,619,621..622,625..626) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 582..604 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 611..627 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..709 /gene="SWI5" /locus_tag="YDR146C" /coded_by="NM_001180453.1:1..2130" /experiment="EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:3284746]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8816483]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8816483]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10409653]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:11562354|PMID:10319811]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10409653]" /experiment="EXISTENCE:mutant phenotype:GO:0010458 exit from mitosis [PMID:9529390|PMID:9017392]" /experiment="EXISTENCE:mutant phenotype:GO:0031496 positive regulation of mating type switching [PMID:6436497]" /experiment="EXISTENCE:mutant phenotype:GO:0036033 mediator complex binding [PMID:11562354]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9529390|PMID:9017392]" /experiment="EXISTENCE:physical interaction:GO:0036033 mediator complex binding [PMID:11562354]" /note="Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication" /db_xref="GeneID:851724" /db_xref="SGD:S000002553" ORIGIN 1 mdtsnswfda skvqslnfdl qtnsyysnar gsdpssyaie geyktlatdd lgnilnlnyg 61 etnevimnei ndlnlplgpl sdeksvkvst fseligndwq smnfdlenns revtlnatsl 121 lnenrlnqds gmtvyqktms dkphdekkis madnllstin kseinkgfdr nlgelllqqq 181 qelreqlraq qeankklele lkqtqykqqq lqatlensdg pqflspkrki spasenvedv 241 yanslspmis ppmsntsftg spsrrnnrqk yclqrknssg tvgplcfqel negfndslis 301 pkkirsnpne nlssktkfit pftpksrvss atsnsanitp nnlrldfkin vedqeseyse 361 kplglgiell gkpgpsptks vslksasvdi mptipgsvnn tpsvnkvsls ssyidqytpr 421 gkqlhfssis enalginaat phlkppsqqa rhregvfndl dpnvltkntd negddneene 481 pesrfviset pspvlksqsk yegrspqfgt hikeintytt nspskitrkl ttlprgsidk 541 yvkempdktf eclfpgctkt fkrrynirsh iqthledrpy scdhpgcdka fvrnhdlirh 601 kkshqekaya cpcgkkfnre dalvvhrsrm icsggkkyen vvikrsprkr grprkdgtss 661 vssspikeni nkdhngqlmf kledqlrrer sydgngtgim vspmktnqr // LOCUS NP_010431 534 aa linear PLN 30-JUN-2025 DEFINITION bifunctional choline kinase/ethanolamine kinase EKI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010431 VERSION NP_010431.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180454.3 REFERENCE 1 (residues 1 to 534) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 534) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 534) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 534) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11990. On Jul 30, 2012 this sequence version replaced NP_010431.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..534 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..534 /product="bifunctional choline kinase/ethanolamine kinase EKI1" /EC_number="2.7.1.82" /calculated_mol_wt="61526" Region 79..129 /region_name="Choline_kin_N" /note="Choline kinase N terminus; pfam04428" /db_xref="CDD:367938" Region 135..508 /region_name="ETNK_euk" /note="Euykaryotic Ethanolamine kinase; cd05157" /db_xref="CDD:270706" Site order(141,143,145..146,148,160,162,191,203..206,208, 210..211,329,331,333..334,336,353..354,357,373,378) /site_type="active" /note="putative active site [active]" /db_xref="CDD:270706" Site order(141,146,148,160,162,191,203..206,208,210..211,333, 336,353..354) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270706" Site order(143,145,329,331,334,357,373,378) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:270706" Site order(276,280..282,285..286,292,296,432,495..496,499, 502..503,506..508) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:270706" CDS 1..534 /gene="EKI1" /locus_tag="YDR147W" /coded_by="NM_001180454.3:1..1605" /experiment="EXISTENCE:direct assay:GO:0004103 choline kinase activity [PMID:10329685]" /experiment="EXISTENCE:direct assay:GO:0004305 ethanolamine kinase activity [PMID:10329685]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004103 choline kinase activity [PMID:10329685]" /experiment="EXISTENCE:genetic interaction:GO:0004305 ethanolamine kinase activity [PMID:10329685]" /experiment="EXISTENCE:genetic interaction:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:10329685]" /experiment="EXISTENCE:genetic interaction:GO:0006656 phosphatidylcholine biosynthetic process [PMID:10329685]" /experiment="EXISTENCE:mutant phenotype:GO:0004305 ethanolamine kinase activity [PMID:10329685]" /experiment="EXISTENCE:mutant phenotype:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:10329685]" /experiment="EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:10329685]" /note="Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication" /db_xref="GeneID:851725" /db_xref="SGD:S000002554" ORIGIN 1 mytnysltss damprtylvg taspemskkk rqsancdkpt rrvihiidtn ehsevdlkne 61 lpitctnedg emtssswtsq tandflklay vnakldpslp sqyfkqdiin vlqsleipgw 121 svpgskessl nknlltltqi kgaltnviyk ihypnlppll mrifgdsids vidreyelkv 181 iarlsfydlg pklegffeng rfekyiegsr tstqadfidr dtsikiakkl kelhctvplt 241 hkeitdqpsc wttfdqwikl idshkewvsn nvnisenlrc sswnfflksf knykrwlynd 301 saftskllre ddkdsminsg lkmvfchndl qhgnllfksk gkddisvgdl tiidfeyagp 361 npvvfdlsnh lnewmqdynd vqsfkshidk ypkeedilvf aqsyinhmne nhvkiasqev 421 rilynliiew rpctqlfwcl wallqsgrlp qrpliegekl msekaglgde thlmehknke 481 ngkydcsedd sfnylgfcke kmsvfwgdli tlgvidkdcp digktdyldt klif // LOCUS NP_010432 463 aa linear PLN 30-JUN-2025 DEFINITION dihydrolipoyl transsuccinylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010432 VERSION NP_010432.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180455.3 REFERENCE 1 (residues 1 to 463) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 463) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 463) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 463) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11991. On Jul 30, 2012 this sequence version replaced NP_010432.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..463 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..463 /product="dihydrolipoyl transsuccinylase" /EC_number="2.3.1.61" /calculated_mol_wt="50300" Region 74..463 /region_name="sucB" /note="2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); TIGR01347" /db_xref="CDD:273565" CDS 1..463 /gene="KGD2" /locus_tag="YDR148C" /coded_by="NM_001180455.3:1..1392" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10869431|PMID:11926067]" /experiment="EXISTENCE:direct assay:GO:0045252 oxoglutarate dehydrogenase complex [PMID:2072900]" /experiment="EXISTENCE:mutant phenotype:GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity [PMID:2115121]" /experiment="EXISTENCE:mutant phenotype:GO:0006103 2-oxoglutarate metabolic process [PMID:2115121]" /experiment="EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:2115121]" /note="Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated" /db_xref="GeneID:851726" /db_xref="SGD:S000002555" ORIGIN 1 mlsratrtaa akslvkskva rnvmaasfvk rhastslfkq ankveslgsi ylsgkkisva 61 anpfsitsnr fkstsievpp maesltegsl keytknvgdf ikedellati etdkidievn 121 spvsgtvtkl nfkpedtvtv geelaqvepg eapaegsges kpepteqaep sqgvaarens 181 seetaskkea apkkeaapkk evtepkkadq pkktvskaqe ppvasnsftp fprtetrvkm 241 nrmrlriaer lkesqntaas lttfnevdms almemrklyk deiikktgtk fgfmglfska 301 ctlaakdipa vngaiegdqi vyrdytdisv avatpkglvt pvvrnaesls vldieneivr 361 lshkardgkl tledmtggtf tisnggvfgs lygtpiinsp qtavlglhgv kerpvtvngq 421 ivsrpmmyla ltydhrlldg reavtflktv keliedprkm llw // LOCUS NP_010434 2748 aa linear PLN 30-JUN-2025 DEFINITION Num1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010434 VERSION NP_010434.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180457.1 REFERENCE 1 (residues 1 to 2748) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2748) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 2748) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2748) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 2748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 2748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11992. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2748 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..2748 /product="Num1p" /calculated_mol_wt="312903" Region <102..>290 /region_name="Mplasa_alph_rch" /note="helix-rich Mycoplasma protein; TIGR04523" /db_xref="CDD:275316" Region 2566..2684 /region_name="Mcp5_PH" /note="Meiotic cell cortex C-terminal pleckstrin homology; pfam12814" /db_xref="CDD:403884" Site order(2579,2581,2597,2614,2666) /site_type="other" /note="putative Rac1 binding site [polypeptide binding]" /db_xref="CDD:270171" Site order(2582,2584,2594,2596,2598,2613..2614) /site_type="other" /note="putative phosphoinositide binding site [chemical binding]" /db_xref="CDD:270171" CDS 1..2748 /gene="NUM1" /locus_tag="YDR150W" /gene_synonym="PAC12" /coded_by="NM_001180457.1:1..8247" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:15023338]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:25083872]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11121446]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11121446]" /experiment="EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:11266443]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:37366411]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:23341591|PMID:26839174|PMID:17336903]" /experiment="EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:23341591|PMID:26839174]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:23341591|PMID:26839174|PMID:23641071]" /experiment="EXISTENCE:mutant phenotype:GO:0000226 microtubule cytoskeleton organization [PMID:11121446]" /experiment="EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:17336903]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:11121446]" /experiment="EXISTENCE:mutant phenotype:GO:0048312 intracellular distribution of mitochondria [PMID:20505073|PMID:23341591|PMID:26839174]" /note="Protein required for nuclear migration; component of the mitochondria-ER-cortex-anchor (MECA); required for the association of mitochondria with the cell cortex and for accurate distribution of mitochondrial network; interacts with Mdm36p to link the ER and mitochondria at the cortex; localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex" /db_xref="GeneID:851727" /db_xref="SGD:S000002557" ORIGIN 1 mshnnrhkkn ndkdssagqy ansidnslsq esvstngvtr manlkadecg sgdegdktkr 61 fsissilskr etkdvlpefa gssshngvlt ansskdmnft lelsenllve crklqssnea 121 kneqikslkq ikeslsdkie eltnqkksfm keldstkdln wdleskltnl smecrqlkel 181 kkktekswnd ekeslkllkt dleiltltkn gmendlssqk lhydkeisel kerildlnne 241 ndrllisvsd ltseinslqs nrterikiqk qlddakasis slkrkvqkky yqkqhtsdtt 301 vtsdpdsegt tseedifdiv ieidhmietg psvedisedl vkkyseknnm illsndsykn 361 llqksesask pkddelmtke vaenlnmial pnddnyskke fsleshikyl easgykvlpl 421 eefenlnesl snpsynylke klqalkkipi dqstfnllke ptidfllplt skidcliipt 481 kdyndlfesv knpsieqmkk cleakndlqs nickwleern gckwlsndly fsmvnkietp 541 skqylsdkak eydqvlidtk aleglknpti dflrekasas dylllkkedy vspsleylve 601 hakatnhhll sdsayedlvk ckenpdmefl keksaklght vvsneaysel ekkleqpsle 661 ylvehakatn hhllsdsaye dlvkckenpd meflkeksak lghtvvsnea yselqrkyse 721 lekeveqpsl aylvehakat dhhllsdsay edlvkckenp dveflkeksa klghtvvsse 781 eyselqrkys elekeveqps laylvehaka tdhhllsdsa yeelvkcken pdmeflkeks 841 aklghtvvsn eayselekkl eqpslaylve hakatdhhll sdsayedlvk ckensdvefl 901 keksaklght vvsneaysel ekkleqpsla ylvehakatd hhllsdsaye dlvkckenpd 961 meflkeksak lghtvvsnea yselekkleq psleylveha katnhhllsd sayedlvkck 1021 enpdmeflke ksaklghtvv sneayselek kleqpsleyl vehakatnhh llsdsayeel 1081 vkckenpdve flkeksaklg htvvsneays elekkleqps leylvehaka tnhhllsdsa 1141 yeelvkcken pdveflkeks aklghtvvsn eayselekkl eqpslaylve hakatdhhll 1201 sdsayedlvk ckenpdvefl keksaklght vvsneaysel ekkleqpsla ylvehakatd 1261 hhllsdsaye dlvkckenpd meflkeksak lghtvvsnea yselekkleq psleylveha 1321 katnhhllsd sayedlvkck enpdmeflke ksaklghtvv snkeyselek kleqpsleyl 1381 vkhaeqiqsk iisisdfntl anpsmedmas klqkleyqiv sndeyialkn tmekpdvell 1441 rsklkgyhii dtttynelvs nfnsptlkfi eekakskgyr liepneyldl nriattpske 1501 eidnfckqig cyaldskeye rlknslenps kkfieenaal ldlvlvdkte yqamkdnasn 1561 kkslipstka ldfvtmpapq lasaeksslq krtlsdiene lkalgyvair kenlpnlekp 1621 ivdnaskndv lnlcskfslv plsteeydnm rkehtkilni lgdpsidflk ekcekyqmli 1681 iskhdyeekq eaienpgyef ilekasalgy elvseveldr mkqmidspdi dymqekaarn 1741 emvllrneek ealqkkieyp sltfliekaa gmnkilvdqi eydetirkcn hptrmelees 1801 chhlnlvlld qneystlrep lenrnvedli ntlsklnyia ipntiyqdli gkyenpnfdy 1861 lkdslnkmdy vaisrqdyel mvakyekpql dylkisseki dhivvplsey nlmvtnyrnp 1921 slsylkekav lnnhiliked dyknilavse hptvihlsek asllnkvlvd kddfatmsrs 1981 iekptidfls tkalsmgkil vnesthkrne kllsepdsef ltmkakeqgl iiisekeyse 2041 lrdqidrpsl dvlkekaaif dsiiveniey qqlvnttspc ppityedlkv yahqfgmelc 2101 lqkpnklsga eraerideqs inttssnstt tssmftdald dnieelnrve lqnnedytdi 2161 isksstvkda tifipayeni knsaeklgyk lvpfeksnin lknieaplfs kdnddtsvas 2221 sidldhlsrk aekygmtlis dqefeeyhil kdnavnlngg meemnnplse nqnlaakttn 2281 taqegafqnt vphndmdnee veygpddptf tvrqlkkpag drnliltsre ktllsrddni 2341 msqneavygd disdsfvdes qeikndvdii ktqamkygml cipesnfvga syasaqdmsd 2401 ivvlsasyyh nlmspedmkw ncvsneelqa evkkrglqia lttkedkkgq ataskheyvs 2461 hklnnktstv stksgakkgl aeaaattaye dseshpqiee qshrtnhhkh hkrqqslnsn 2521 stsktthssr ntpasrrdiv asfmsragsa srtaslqtla slnepsiipa ltqtvigeyl 2581 fkyyprlgpf gfesrherff wvhpytltly wsasnpilen pantktkgva ilgvesvtdp 2641 npyptglyhk sivvttetrt ikftcptrqr hniwynslry llqrnmqgis lediaddptd 2701 nmysgkifpl pgentksssk rlsasrrsvs trslrhrvpq srsfgnlr // LOCUS NP_010435 325 aa linear PLN 30-JUN-2025 DEFINITION putative mRNA-binding protein CTH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010435 VERSION NP_010435.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180458.1 REFERENCE 1 (residues 1 to 325) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 325) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 325) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 325) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11993. Method: conceptual translation. FEATURES Location/Qualifiers source 1..325 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..325 /product="putative mRNA-binding protein CTH1" /calculated_mol_wt="36641" Region 1..323 /region_name="CTH1" /note="CCCH-type Zn-finger protein [General function prediction only]; COG5063" /db_xref="CDD:227395" CDS 1..325 /gene="CTH1" /locus_tag="YDR151C" /coded_by="NM_001180458.1:1..978" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:15652485]" /experiment="EXISTENCE:genetic interaction:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:15652485]" /experiment="EXISTENCE:genetic interaction:GO:0006879 intracellular iron ion homeostasis [PMID:15652485]" /note="mRNA binding protein, member of CCCH zinc finger family; similar to mammalian Tis11, which activates transcription and has role in mRNA degradation; functions with Tis11p in regulation of iron homeostasis; represses translation in response to iron limitation, downregulating multiple transcripts required for mitochondrial translation and heme biosynthesis; inhibits the iron-dependent ribosome recycling factor, Rli1p" /db_xref="GeneID:851729" /db_xref="SGD:S000002558" ORIGIN 1 mmpnvapnsy ylnipnanst stttssifsd lnkeyeskik eieeyyiktl lnentdndds 61 ssseghnine tdilseyspr pspwlpskpn cyhplgdfkd liisdsrptn tlpinnpfag 121 nnnistlatt ekkrkkrsle veinptytts afslpltaen lqklsqvdsq stglpytlpi 181 qkttklepcr raplqlpqlv nktlyktelc esftikgyck ygnkcqfahg lnelkfkkks 241 nnyrtkpcin wsklgycpyg krccfkhgdd kdveiyqnan dgrskdtalt plptslapsn 301 ndnitnlskp rnlhtsvkal qrmtw // LOCUS NP_010436 265 aa linear PLN 30-JUN-2025 DEFINITION Gir2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010436 VERSION NP_010436.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180459.3 REFERENCE 1 (residues 1 to 265) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 265) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 265) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 265) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11994. On Jul 30, 2012 this sequence version replaced NP_010436.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..265 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..265 /product="Gir2p" /calculated_mol_wt="30900" Region 3..160 /region_name="RWD_ScGIR2-like" /note="RWD domain of Saccharomyces cerevisiae genetically interacts with ribosomal genes protein 2 (GIR2) and related proteins; cd23824" /db_xref="CDD:467660" Site order(10,67) /site_type="other" /note="putative Gcn1 interface [polypeptide binding]" /db_xref="CDD:467660" CDS 1..265 /gene="GIR2" /locus_tag="YDR152W" /coded_by="NM_001180459.3:1..798" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:21076151]" /experiment="EXISTENCE:genetic interaction:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:23899355]" /experiment="EXISTENCE:mutant phenotype:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:23899355]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:23899355]" /note="Highly-acidic RWD domain-containing cytoplasmic protein; forms a highly conserved complex with Rbg2p that is responsible for efficient cell growth under amino acid starvation and binds translational activator Gcn1p in dose-dependent manner according to stress level; associates with translating ribosomes; intrinsically unstructured protein whose stability is enhanced upon binding Rbg2p" /db_xref="GeneID:851730" /db_xref="SGD:S000002559" ORIGIN 1 mdykeeqkqe levlesiypd elriindeyp kikfevaikl eldtgdstsv ltkehtiiae 61 fklpenypde pclisleaqe valndneedn eededeveyd dhgnkvlkkf enlpdlisfk 121 gylpeltvql esqietdmll gmqmcfalis sikerceqwy seqlnklekq yeleaqerek 181 keqakfhgtk vtresylewr skfrqelkld erdqvrrmka hhgkltgkqm feqgvvgtgd 241 eymeeddasv ddvakglakt eianq // LOCUS NP_010437 411 aa linear PLN 30-JUN-2025 DEFINITION Ent5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010437 VERSION NP_010437.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180460.3 REFERENCE 1 (residues 1 to 411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 411) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11995. On Jul 30, 2012 this sequence version replaced NP_010437.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..411 /product="Ent5p" /calculated_mol_wt="47190" Region 33..190 /region_name="ENTH_Ent5" /note="Epsin N-Terminal Homology (ENTH) domain of Yeast Ent5 and similar proteins; cd16993" /db_xref="CDD:340790" Site order(38,42..43,75,100,104) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:340790" CDS 1..411 /gene="ENT5" /locus_tag="YDR153C" /coded_by="NM_001180460.3:1..1236" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:15107463]" /experiment="EXISTENCE:direct assay:GO:0030125 clathrin vesicle coat [PMID:12483220]" /experiment="EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:12483220]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:15107463]" /experiment="EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:20658963]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:12483220]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:15107463]" /experiment="EXISTENCE:mutant phenotype:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:15107463]" /note="Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin" /db_xref="GeneID:851731" /db_xref="SGD:S000002560" ORIGIN 1 mdslskkiqn lgihdirnaa rfaqnvivqy epyqidirra tntdawgptp khlakvlrnr 61 yqvplylmte ytlkrlvdhi atrpknlyek arkdyvnygs ewrvvlkclv vieflllnvd 121 tgdelnqirs cllthkhilt reiaqfkvkf sndgkmeihe rgirkkgeli lqyledsqfl 181 kkeraknkkn alkirqqges siynanqist sasydniddd efdadadgfd semdannvtn 241 fnvpvetean sntrrrshme eqrrqrreil reqiknkeqq rkrkqqqdsi pdlidlddst 301 sttnnitidn gnndnknnni nsnsddddde fgdfqsetsp dttapktsns kiddlldwdg 361 pksdtdttaa aqtslpfaek kqqkarpqat kdkskgndaf sdlfsysksl v // LOCUS NP_010439 162 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase CPR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010439 VERSION NP_010439.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180462.1 REFERENCE 1 (residues 1 to 162) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 162) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 162) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 162) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11996. Method: conceptual translation. FEATURES Location/Qualifiers source 1..162 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..162 /product="peptidylprolyl isomerase CPR1" /EC_number="5.2.1.8" /calculated_mol_wt="17260" Region 2..160 /region_name="cyclophilin_ABH_like" /note="Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding...; cd01926" /db_xref="CDD:238907" Site order(52..53,58,109,111,119) /site_type="active" /db_xref="CDD:238907" CDS 1..162 /gene="CPR1" /locus_tag="YDR155C" /gene_synonym="CPH1; CYP1" /coded_by="NM_001180462.1:1..489" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:2687115]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15643056]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0034967 Set3 complex [PMID:11711434]" /experiment="EXISTENCE:genetic interaction:GO:0045836 positive regulation of meiotic nuclear division [PMID:15643056]" /experiment="EXISTENCE:mutant phenotype:GO:0016018 cyclosporin A binding [PMID:7515500]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:15643056]" /experiment="EXISTENCE:mutant phenotype:GO:0045836 positive regulation of meiotic nuclear division [PMID:15643056]" /experiment="EXISTENCE:physical interaction:GO:0034967 Set3 complex [PMID:15643056]" /note="Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; N-terminally propionylated in vivo; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851733" /db_xref="SGD:S000002562" ORIGIN 1 msqvyfdvea dgqpigrvvf klyndivpkt aenfralctg ekgfgyagsp fhrvipdfml 61 qggdftagng tggksiyggk fpdenfkkhh drpgllsman agpntngsqf fittvpcpwl 121 dgkhvvfgev vdgydivkkv eslgspsgat karivvaksg el // LOCUS NP_010440 137 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase I subunit RPA14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010440 VERSION NP_010440.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180463.1 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11997. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..137 /product="DNA-directed RNA polymerase I subunit RPA14" /calculated_mol_wt="14454" Region 15..137 /region_name="RNA_polI_A14" /note="Yeast RNA polymerase I subunit RPA14; pfam08203" /db_xref="CDD:462394" CDS 1..137 /gene="RPA14" /locus_tag="YDR156W" /coded_by="NM_001180463.1:1..414" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:7768955|PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:9121426]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:7768955]" /note="RNA polymerase I subunit A14" /db_xref="GeneID:851734" /db_xref="SGD:S000002563" ORIGIN 1 mmkgsrrtgn ntattlntpv vihatqlpqh vstdevlqfl esfidekeni idsttmntis 61 gnaadadaaa vantslnidt nlsssisqlk riqrdfkglp paqdfsaapi qvsttekket 121 sigvsatggk kttfade // LOCUS NP_001335757 133 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR157W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335757 VERSION NP_001335757.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348811.1 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80277. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..133 /product="uncharacterized protein" /calculated_mol_wt="15376" CDS 1..133 /locus_tag="YDR157W" /coded_by="NM_001348811.1:1..402" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:851735" /db_xref="SGD:S000002564" ORIGIN 1 msetcsssla llhkilhihs htpsvyynic isvriltser lqcfffsffp dpnitgsglk 61 vpgflffhtf ffsksccqal idsfssdyyq fkmleknrka ekinkrtifi csftfeykik 121 scfscfhlst htn // LOCUS NP_010442 365 aa linear PLN 30-JUN-2025 DEFINITION aspartate-semialdehyde dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010442 VERSION NP_010442.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180465.3 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11998. On Jul 30, 2012 this sequence version replaced NP_010442.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..365 /product="aspartate-semialdehyde dehydrogenase" /EC_number="1.2.1.11" /calculated_mol_wt="39413" Region 7..365 /region_name="PRK08664" /note="aspartate-semialdehyde dehydrogenase; Reviewed" /db_xref="CDD:236329" CDS 1..365 /gene="HOM2" /locus_tag="YDR158W" /gene_synonym="THR2" /coded_by="NM_001180465.3:1..1098" /experiment="EXISTENCE:direct assay:GO:0004073 aspartate-semialdehyde dehydrogenase activity [PMID:4145650]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:4380684]" /experiment="EXISTENCE:mutant phenotype:GO:0009088 threonine biosynthetic process [PMID:4380684]" /experiment="EXISTENCE:mutant phenotype:GO:0009090 homoserine biosynthetic process [PMID:4380684]" /note="Aspartic beta semi-aldehyde dehydrogenase; catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis" /db_xref="GeneID:851736" /db_xref="SGD:S000002565" ORIGIN 1 magkkiagvl gatgsvgqrf illlanhphf elkvlgassr sagkkyvdav nwkqtdllpe 61 satdiivsec kseffkecdi vfsgldadya gaiekefmea giaivsnakn yrreqdvpli 121 vpvvnpehld ivaqkldtak aqgkprpgfi icisncstag lvaplkplie kfgpidaltt 181 ttlqaisgag fspgvpgidi ldniipyigg eedkmewetk kilaplaedk thvklltpee 241 ikvsaqcnrv avsdghteci slrfknrpap sveqvktclk eyvcdayklg chsapkqtih 301 vleqpdrpqp rldrnrdsgy gvsvgrired plldfkmvvl shntiigaag sgvliaeill 361 arnli // LOCUS NP_010443 1301 aa linear PLN 30-JUN-2025 DEFINITION Sac3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010443 VERSION NP_010443.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180466.3 REFERENCE 1 (residues 1 to 1301) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1301) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1301) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1301) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11999. On Jul 30, 2012 this sequence version replaced NP_010443.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1301 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1301 /product="Sac3p" /calculated_mol_wt="149438" Region 103..812 /region_name="SAC3" /note="Nuclear protein export factor [Intracellular trafficking and secretion / Cell division and chromosome partitioning]; COG5079" /db_xref="CDD:227411" CDS 1..1301 /gene="SAC3" /locus_tag="YDR159W" /gene_synonym="LEP1" /coded_by="NM_001180466.3:1..3906" /experiment="EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:12631707]" /experiment="EXISTENCE:direct assay:GO:0070390 transcription export complex 2 [PMID:15311284]" /experiment="EXISTENCE:genetic interaction:GO:0006406 mRNA export from nucleus [PMID:12631707]" /experiment="EXISTENCE:genetic interaction:GO:0030029 actin filament-based process [PMID:2656401]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:8799844]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:18003937]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:12411502|PMID:12631707]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:10716708]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:18614048]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:19806183]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:18003937]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12411502]" /experiment="EXISTENCE:physical interaction:GO:0006406 mRNA export from nucleus [PMID:12631707]" /note="mRNA export factor; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)" /db_xref="GeneID:851737" /db_xref="SGD:S000002566" ORIGIN 1 mntsfgsvvp stnfnffkgh gnndntsans tvnnsnffln snetkpsknv fmvhstsqkk 61 sqqplqnlsh spsytenkpd kkkkyminda ktiqlvgpli sspdnlgfqk rshkarelpr 121 flinqepqle krafvqdpwd kanqekmisl eesiddlnel yetlkkmrnt ersimeekgl 181 vdkadsakdl ydaivfqgtc ldmcptfers rrnveytvys yeknqpndkk asrtkalkvf 241 arpaaaaapp lpsdvrpphi lvktldyivd nllttlpese gflwdrmrsi rqdftyqnys 301 gpeavdcner ivrihllilh imvksnvefs lqqeleqlhk slitlseiyd dvrssggtcp 361 neaefrayal lskirdpqyd eniqrlpkhi fqdklvqmal cfrrvisnsa ytergfvkte 421 nclnfyarff qlmqspslpl lmgfflqmhl tdirfyalra lshtlnkkhk pipfiylenm 481 llfnnrqeii efcnyysiei ingdaadlkt lqhyshklse tqplkktylt clerrlqktt 541 ykglingged nlassvyvkd pkkdripsia dqsflmenfq nnyneklnqn ssvkpqints 601 pkrvatrpnh fpfsqeskql pqisqshtls tnplltpqvh gdlseqkqqq iktvtdggsp 661 fvfdqsaqns tveaskahmi sttsngayde klsseqeemr kkeeqrieee ktqlkkkqen 721 adkqviteqi andlvkevvn ssvisivkre fseanyrkdf idtmtrelyd aflherlyli 781 ymdsraelkr nstlkkkffe kwqasysqak knrileekkr eeiklvshql gvpgfkkstc 841 lfrtpykgnv nssfmlsssd knlifspvnd efnkfathlt kisklwrple mqsiyydnlt 901 kkfpsnsltp anlfiyakdw tslsnrwils kfnlqtaqds kkfsnniiss riiciddeye 961 psdfsdlqll ifntgvtnpd ifdlemklkd dgeeliklit gislntnicf slliiywesa 1021 entlsestik hllklnrisk nyssvierid lmnlteesph kcledklsei shsyvyklte 1081 rgkydktlrq krslagihsr stqlqttkdi dqkmkkmlek eknkyqqqig erntyahles 1141 hidasprskk rklpillsts hssqfktpla srlntsgsst spplpshlam kfrknsrvts 1201 lhtvlpvstp shsnnipaas fsgnnttdiq sqqlienqks tsvylnnvse rilgnqeicq 1261 tpinpvtpvl dgadqgkedi pdsilelkil idsvkkkvnn d // LOCUS NP_010444 852 aa linear PLN 30-JUN-2025 DEFINITION Ssy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010444 VERSION NP_010444.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180467.1 REFERENCE 1 (residues 1 to 852) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 852) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 852) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 852) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12000. Method: conceptual translation. FEATURES Location/Qualifiers source 1..852 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..852 /product="Ssy1p" /calculated_mol_wt="95614" Region 278..819 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..852 /gene="SSY1" /locus_tag="YDR160W" /gene_synonym="RAA1; SHR10" /coded_by="NM_001180467.1:1..2559" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:24124599|PMID:10409731]" /experiment="EXISTENCE:mutant phenotype:GO:0043200 response to amino acid [PMID:10409731]" /note="Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p" /db_xref="GeneID:851738" /db_xref="SGD:S000002567" ORIGIN 1 mssvnqiydl fpnkhniqft dshsqehdts sslakndtdg tisipgsidt gilksiieeq 61 gwndaelyrs siqnqrfflt dkytkkkhlt medmlspeee qiyqepiqdf qtynkrvqre 121 yelrermeef frqntkndlh ilnedslnqq ysplgpadyv lpldrysrmk hiasnffrkk 181 lgiprklkrr shynpnaegh tkgnssilss ttdvidnasy rniaidenvd ithkehaide 241 ineqgasgse svveggsllh diekvfnrsr atrkyhiqrk lkvrhiqmls igacfsvglf 301 ltsgkafsia gpfgtllgfg ltgsiilatm lsftelstli pvssgfsgla srfvedafgf 361 algwtywisc mlalpaqvss stfylsyynn vniskgvtag fitlfsafsi vvnlldvsim 421 geivyvagis kviiailmvf tmiilnaghg ndihegvgfr ywdssksvrn ltyglyrptf 481 dladagegsk kgisgpkgrf latasvmlis tfafsgvemt flasgeainp rktipsatkr 541 tfsivlisyv flifsvgini ysgdprllsy fpgisekrye aiikgtgmdw rlrtncrggi 601 dyrqisvgtg ysspwvvalq nfglctfasa fnailiffta tagisslfsc srtlyamsvq 661 rkappvfeic skrgvpyvsv ifsslfsvia yiavdqtaie nfdvlanvss astsiiwmgl 721 nlsflrfyya lkqrkdiisr ndssypyksp fqpylaiygl vgcslfvifm gypnfihhfw 781 stkaffsayg glmfffisyt aykvlgtski qrldqldmds grremdrtdw tehsqylgty 841 rerakklvtw li // LOCUS NP_010445 387 aa linear PLN 30-JUN-2025 DEFINITION Acl4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010445 VERSION NP_010445.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180468.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12001. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..387 /product="Acl4p" /calculated_mol_wt="42812" Region 5..350 /region_name="ACL4-like" /note="Assembly chaperone of ribosomal protein L4 and similar proteins; cd24142" /db_xref="CDD:467942" CDS 1..387 /gene="ACL4" /locus_tag="YDR161W" /coded_by="NM_001180468.1:1..1164" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:26447800|PMID:25936803]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:26447800]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:25936803]" /experiment="EXISTENCE:direct assay:GO:0140318 protein transporter activity [PMID:26447800]" /experiment="EXISTENCE:genetic interaction:GO:0051083 'de novo' cotranslational protein folding [PMID:19325107]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:25936803|PMID:26447800]" /note="Specific assembly chaperone for ribosomal protein Rpl4a/Rpl4b; associates co-translationally with a evolutionarily conserved internal loop of nascent Rpl4a/b, and is released only after an the eukaryotic-specific extension of nascent Rpl4a/b mediates nuclear import, incorporation into the pre-ribosome and complex disassembly; role in biogenesis of the 60S ribosomal subunit; transcriptionally co-regulated with rRNA and ribosome biosynthesis genes" /db_xref="GeneID:851739" /db_xref="SGD:S000002568" ORIGIN 1 mseleatirq akealaenna kkalkilkpf ksslkkenan nvilnevfad ayldngqvek 61 aypilarace ldpegqvggp dkfftmgqim ggqdgvsiit rgimnisntg gemltnvqve 121 kivggllsvi eiwmtdlcme pnaeeqceel iqkamelteg kspetwstlg sikisqqkfg 181 eayeafsqaw nffelkkqei gsginengdt tqkaglqsey vdllqpllsl tkmclevgay 241 evalkviaav rdidednieg yylegftyyl mskleifkln npevslrpen iyefnqliqe 301 vpldlshepi sqliydsrla lsfalqagvn adskdeivqe llgganallq eiggpldpse 361 ltqikkgdlv nenedleeld ieeeysd // LOCUS NP_010446 236 aa linear PLN 30-JUN-2025 DEFINITION adaptor protein NBP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010446 VERSION NP_010446.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180469.3 REFERENCE 1 (residues 1 to 236) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 236) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 236) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 236) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12002. On Jul 30, 2012 this sequence version replaced NP_010446.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..236 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..236 /product="adaptor protein NBP2" /calculated_mol_wt="26440" Region 114..168 /region_name="SH3_Nbp2-like" /note="Src Homology 3 domain of Saccharomyces cerevisiae Nap1-binding protein 2 and similar fungal proteins; cd11865" /db_xref="CDD:212799" Site order(119,121,124..125,127..128,141,143..147,149,158..160, 162,164..165) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212799" CDS 1..236 /gene="NBP2" /locus_tag="YDR162C" /coded_by="NM_001180469.3:1..711" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14573466]" /experiment="EXISTENCE:genetic interaction:GO:0043409 negative regulation of MAPK cascade [PMID:14685261]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:14685261]" /experiment="EXISTENCE:mutant phenotype:GO:0043409 negative regulation of MAPK cascade [PMID:22570491]" /experiment="EXISTENCE:mutant phenotype:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:22570491]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:14685261]" /note="Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p to the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm; contains an SH3 domain and a Ptc1p binding domain (PBM)" /db_xref="GeneID:851740" /db_xref="SGD:S000002569" ORIGIN 1 matmetttqk dtnilksglk ktigvlneav lqngreveav qagnsdtmed tetttigyis 61 ikdyayadsn plhygyfdgd needemvsds sngedtynkr qsitlpddyi vnqravalyd 121 fependnelr laegdivfis ykhgqgwlva enesgsktgl vpeefvsyiq pedgeneven 181 karpfylthl itqsvspknn idntnedeyd dndewedidd vaeveadmkt kldisd // LOCUS NP_010447 175 aa linear PLN 30-JUN-2025 DEFINITION U2-type spliceosomal complex subunit CWC15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010447 VERSION NP_010447.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180470.3 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12003. On Jul 30, 2012 this sequence version replaced NP_010447.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..175 /product="U2-type spliceosomal complex subunit CWC15" /calculated_mol_wt="19804" Region 1..>41 /region_name="Cwf_Cwc_15" /note="Cwf15/Cwc15 cell cycle control protein; pfam04889" /db_xref="CDD:428176" CDS 1..175 /gene="CWC15" /locus_tag="YDR163W" /coded_by="NM_001180470.3:1..528" /experiment="EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:11884590]" /note="Non-essential protein involved in pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf15p" /db_xref="GeneID:851741" /db_xref="SGD:S000002570" ORIGIN 1 mttshrpqle arsgakaaay tptgieharl lpghttlkyr kfkeeenlra ncaqedrsnd 61 ksleeavmne ekqdvvgsgn lqetrsekdq kdslqellvt qknkvedkae legneqlkgg 121 nssrrswrkg tafgrhkvtk etnikehatk ksasgyindm tkseyhqefl hkhvr // LOCUS NP_010448 724 aa linear PLN 30-JUN-2025 DEFINITION Sec1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010448 VERSION NP_010448.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180471.1 REFERENCE 1 (residues 1 to 724) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 724) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 724) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 724) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12004. Method: conceptual translation. FEATURES Location/Qualifiers source 1..724 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..724 /product="Sec1p" /calculated_mol_wt="83350" Region 1..644 /region_name="SEC1" /note="Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion]; COG5158" /db_xref="CDD:227487" CDS 1..724 /gene="SEC1" /locus_tag="YDR164C" /coded_by="NM_001180471.1:1..2175" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:10427089]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15466482]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10427089|PMID:11038189]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:11038189|PMID:10427089]" /experiment="EXISTENCE:direct assay:GO:0031340 positive regulation of vesicle fusion [PMID:15466482]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:10427089]" /experiment="EXISTENCE:physical interaction:GO:0006887 exocytosis [PMID:10427089]" /experiment="EXISTENCE:physical interaction:GO:0006904 vesicle docking involved in exocytosis [PMID:10427089]" /note="Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function; interacts directly with essential exocyst subunit Sec6p" /db_xref="GeneID:851742" /db_xref="SGD:S000002571" ORIGIN 1 msdlielqrn yligvlnqie tknnlkflii dktvetilsy lfltpqelln nvtsvdlids 61 ptrkgqssie aiyileptky nincidadfm vrppkyrrch irflpgltnp ifqffqskry 121 iaqnlesfkp ielgffvkes qffetlqmeh slqvffnnnc kaliptnvrk ivgslvslcv 181 itgeypivry svsnpveeed arngnavvna nsltrsiana fqiaidtyar nnpdfppqnt 241 erprsiliit drtldpfapi lhdfsyqama ydlvanvdtq kdiyhysaen eageqeekvs 301 klvdlydpdw idlkhqhimd aneyiqgrik eliaknpllv drsnvknttd llsvvahlkd 361 fdeerrrlil hktlvdeclg enaerkladi saieqnlsgf gmdfsgekik hiiddllpal 421 amkeptildk lryiiayalf rggiieldfi kllnfigvth ehenfqqylk ifrnydlidf 481 klikdkpkdk pfqkewfhdt lvndpniyht srfvpavgni lskvianpll lseqyfpylk 541 dkpiellnee efqaglants ansssslrnp rhkaawttks snikkniprq rffyyviggi 601 sipeikaayd qsnlknrdif igsdeiltpt kfldeverlq npreffkfke dqrqqvnppd 661 fllremkpva qpvshvhlks qdnspksgts spkaagslks eppekekkrs kfsrflkrks 721 hhdk // LOCUS NP_010449 444 aa linear PLN 30-JUN-2025 DEFINITION Trm82p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010449 VERSION NP_010449.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180472.1 REFERENCE 1 (residues 1 to 444) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 444) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 444) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 444) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12005. Method: conceptual translation. FEATURES Location/Qualifiers source 1..444 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..444 /product="Trm82p" /calculated_mol_wt="50357" Region 7..46 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 106..148 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <112..278 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 152..192 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 199..238 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 244..279 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 310..352 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..444 /gene="TRM82" /locus_tag="YDR165W" /coded_by="NM_001180472.1:1..1335" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22932476|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:17382321]" /experiment="EXISTENCE:direct assay:GO:0106004 tRNA (guanine-N7)-methylation [PMID:17382321]" /experiment="EXISTENCE:direct assay:GO:0106143 tRNA (m7G46) methyltransferase complex [PMID:18184583|PMID:12403464|PMID:17382321]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:12403464]" /experiment="EXISTENCE:mutant phenotype:GO:0106004 tRNA (guanine-N7)-methylation [PMID:12403464]" /note="Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; mutation in human ortholog WDR4 causes microcephalic primordial dwarfism" /db_xref="GeneID:851743" /db_xref="SGD:S000002572" ORIGIN 1 msvihplqnl ltsrdgslvf aiikncilsf kyqspnhwef agkwsddfdk iqesrnttak 61 eqqgqssene nenkklksnk gdsikrtaak vpspglgapp iysyirnlrl tsdesrliac 121 adsdksllvf dvdktsknvl klrkrfcfsk rpnaisiaed dttviiadkf gdvysidins 181 ipeekftqep ilghvsmltd vhlikdsdgh qfiitsdrde hikishypqc fivdkwlfgh 241 khfvssiccg kdylllsagg ddkifawdwk tgknlstfdy nslikpylnd qhlapprfqn 301 enndiiefav skiiksknlp fvaffveatk ciiilemsek qkgdlalkqi itfpynvisl 361 sahndefqvt ldnkessgvq knfakfieyn lnensfvvnn eksnefdsai iqsvqgdsnl 421 vtkkeeiypl ynvsslrkhg ehys // LOCUS NP_010450 971 aa linear PLN 30-JUN-2025 DEFINITION exocyst subunit SEC5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010450 VERSION NP_010450.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180473.3 REFERENCE 1 (residues 1 to 971) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 971) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 971) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 971) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12006. On Jul 30, 2012 this sequence version replaced NP_010450.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..971 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..971 /product="exocyst subunit SEC5" /calculated_mol_wt="111991" Region 80..970 /region_name="Sec5" /note="Exocyst complex component Sec5; pfam15469" /db_xref="CDD:464733" CDS 1..971 /gene="SEC5" /locus_tag="YDR166C" /coded_by="NM_001180473.3:1..2916" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11595741]" /experiment="EXISTENCE:direct assay:GO:0000145 exocyst [PMID:8978675]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11595741|PMID:17717527]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:11595741]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:15583030]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:mutant phenotype:GO:0001927 exocyst assembly [PMID:15583030]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:6996832]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:15583030]" /note="Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip" /db_xref="GeneID:851744" /db_xref="SGD:S000002573" ORIGIN 1 mdrfqigdeq llrfyqlkti npthswaqds sklnneeats nelgvetsfd ilkdfkygnq 61 isidkesray lndeslsyir dplngqemsk elqhlpndsm rlnylvnskq fnvkaflrdm 121 hkqdsfndln nsldrldsdi qdqsihlkql vgknftkyvk iknkldqiyk efdektnekn 181 qcdspkenqi nveslnkkvd evirtttfkl kplmdnyqki lnyqatkkfi elnkfyfnlp 241 kslkrcltnn dfnefiieys kgltlrrrfn qssdasqslv ikriwtqien llvtykdliw 301 nslinsnfni dqpqetilsl fskllnlenf innnqreses gnknttsssn enpilrwmsi 361 kmngfqneln elsghmiski ihsqrlilqn ntnqdksqgc velsyylkin qlfqiisdtg 421 kdseglkstv epnkvntisg tsylnlncqp ssqgltdspt iiemwllilk yindlwkicd 481 qfiefwehie kfldgtyqns iinekrkeni ligdsniies yqkslilkee qinevrlkge 541 efitsvsqnl isfftssqss lpsslkdstg ditrsnkdsg spldygfipp ncnglsclry 601 lpkivepilk fstelaqlni ttngiticrn tlstiinrcv gaisstklrd isnfyqlenw 661 qvyetvtfss ksqdssknlt feygvtqfpe ivtsfqevsi kttrdllfay eklpiingis 721 vvsypskqll tgieiqqiis meavleailk naakdkdnpr nshtiltltn lqyfrecafp 781 nilqyfddaf ewnlasknle lfsllskmes sifgnylsdl kinlrdtlee kfheinwpmy 841 tsnsfrvgdy iiealmiliv vhsecfrigp qlihkiliet qifiarylfe afkpyvgnls 901 ndgslqiivd leffqkvmgp llekdteatl raclqncfqn dtnrlqkcin einpivsanl 961 krtaiqfaaf s // LOCUS NP_010451 206 aa linear PLN 30-JUN-2025 DEFINITION Taf10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010451 VERSION NP_010451.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180474.3 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12007. On Jul 30, 2012 this sequence version replaced NP_010451.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..206 /product="Taf10p" /calculated_mol_wt="22888" Region 1..206 /region_name="COG5162" /note="Transcription initiation factor TFIID, subunit TAF10 (also component of histone acetyltransferase SAGA) [Transcription]" /db_xref="CDD:227491" Site order(73..74,77..78,80..81,84..89,92..93,95..97,100..103, 106,108..109,112..113,115..122,124..126,128..129,132, 180..185,188,192,195) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467026" Site order(95,98..103,106,108,120,130,134..135) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467026" CDS 1..206 /gene="TAF10" /locus_tag="YDR167W" /gene_synonym="TAF23; TAF25" /coded_by="NM_001180474.3:1..621" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10817999]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:12138208|PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:8662725]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:11940675]" /note="Subunit (145 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification" /db_xref="GeneID:851745" /db_xref="SGD:S000002574" ORIGIN 1 mdfeedydae fddnqegqle tpfpsvagad dgdndnddsv aenmkkkqkr eavvddgsen 61 afgipeftrk dktleeilem mdstppiipd avidyyltkn gfnvadvrvk rllalatqkf 121 vsdiakdaye ysrirssvav snannsqara rqllqgqqqp gvqqisqqqh qqnekttask 181 vvltvndlss avaeyglnig rpdfyr // LOCUS NP_010452 506 aa linear PLN 30-JUN-2025 DEFINITION Hsp90 co-chaperone CDC37 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010452 VERSION NP_010452.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180475.1 REFERENCE 1 (residues 1 to 506) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 506) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 506) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 506) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12008. Method: conceptual translation. FEATURES Location/Qualifiers source 1..506 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..506 /product="Hsp90 co-chaperone CDC37" /calculated_mol_wt="58254" Region 2..183 /region_name="CDC37_N" /note="Cdc37 N terminal kinase binding; smart01071" /db_xref="CDD:198139" Region 207..368 /region_name="CDC37_M" /note="Cdc37 Hsp90 binding domain; smart01070" /db_xref="CDD:215010" Region 389..490 /region_name="CDC37_C" /note="Cdc37 C terminal domain; smart01069" /db_xref="CDD:215009" CDS 1..506 /gene="CDC37" /locus_tag="YDR168W" /gene_synonym="SMO1" /coded_by="NM_001180475.1:1..1521" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9242486]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:9060463]" /experiment="EXISTENCE:mutant phenotype:GO:0043410 positive regulation of MAPK cascade [PMID:17220467]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:17242065]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:7753858]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:17220467]" /experiment="EXISTENCE:mutant phenotype:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:17220467]" /experiment="EXISTENCE:physical interaction:GO:0038066 p38MAPK cascade [PMID:17220467]" /experiment="EXISTENCE:physical interaction:GO:0071474 cellular hyperosmotic response [PMID:17220467]" /note="Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding" /db_xref="GeneID:851746" /db_xref="SGD:S000002575" ORIGIN 1 maidyskwdk ielsddsdve vhpnvdkksf ikwkqqsihe qrfkrnqdik nletqvdmys 61 hlnkrvdril snlpessltd lpavtkflna nfdkmekskg envdpeiaty nemvedlfeq 121 lakdldkegk dskspslird ailkhrakid svtveakkkl delykeknah issedihtgf 181 dssfmnkqkg gakpleatps ealssaaesn ilnklakssv pqtfidfkdd pmklaketee 241 fgkisineys ksqkfllehl piiseqqkda lmmkafeyql hgddkmtlqv ihqselmayi 301 keiydmkkip ylnpmelsnv inmffekvif nkdkpmgkes flrsvqekfl hiqkrskilq 361 qeemdesnae gvetiqlksl ddstelevnl pdfnskdpee mkkvkvfktl ipekmqeaim 421 tknldninkv fedipieeae kllevfndid iigikailen ekdfqslkdq yeqdhedatm 481 enlslndrdg ggdnheevkh tadtvd // LOCUS NP_010453 513 aa linear PLN 30-JUN-2025 DEFINITION Stb3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010453 VERSION NP_010453.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180476.1 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12009. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..513 /product="Stb3p" /calculated_mol_wt="56133" Region 43..119 /region_name="Stb3" /note="Putative Sin3 binding protein; pfam10330" /db_xref="CDD:402102" CDS 1..513 /gene="STB3" /locus_tag="YDR169C" /coded_by="NM_001180476.1:1..1542" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:17616518|PMID:20385783]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095|PMID:20385783]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363|PMID:17616518]" /experiment="EXISTENCE:mutant phenotype:GO:0000976 transcription cis-regulatory region binding [PMID:17616518]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:17616518]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17616518]" /experiment="EXISTENCE:mutant phenotype:GO:0071333 cellular response to glucose stimulus [PMID:17616518]" /note="Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:851747" /db_xref="SGD:S000002576" ORIGIN 1 msenqkevsp pqaisvksea sssifskpis tsspaglaaa qrvtpgklst lllemgplai 61 rhitqtlcld ipcfkdlsss kqrrlimsam esgdkeksvv fekigwgqws akrvdpanfd 121 keleatnfan akvkdlisqe sqrrksnnsn snsggkvemp mkvehnitni dgattpptav 181 asttipvnik rsksplaaan vvyidenala sededeefde ddhhlhyqnk srnssnnfgk 241 ssngdpysfg rrrsqvvfad stpeniehei iaqkirpllr nrrrssikph tpfisklnth 301 qdssylspnt tstttpsnnn snsnqakidl ekltatsept srrasrlsvs kessirstlf 361 pnknylivtt npnskatsvs tspkleeqmn vssnpivlsd kekhrvasqh lngesspqlv 421 phshhqphsd tdeedwesig aaslrnnsla pnidsvasst ngvvspkptn psftnsqngd 481 iepplqhdqq kheqqprnge dnsaafllms lks // LOCUS NP_878062 49 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR169C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878062 VERSION NP_878062.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184544.3 REFERENCE 1 (residues 1 to 49) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 49) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 49) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 49) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12010. On Jul 30, 2012 this sequence version replaced NP_878062.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..49 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..49 /product="uncharacterized protein" /calculated_mol_wt="5457" CDS 1..49 /locus_tag="YDR169C-A" /coded_by="NM_001184544.3:1..150" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466433" /db_xref="SGD:S000028538" ORIGIN 1 mmrmslkqmq sqrfsatsrv rmlligasgl rssssklecp rfsnkhgrn // LOCUS NP_010454 2009 aa linear PLN 30-JUN-2025 DEFINITION Arf family guanine nucleotide exchange factor SEC7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010454 VERSION NP_010454.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180477.3 REFERENCE 1 (residues 1 to 2009) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2009) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 2009) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2009) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2009) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2009) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2009) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 2009) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 2009) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12011. On Jul 30, 2012 this sequence version replaced NP_010454.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2009 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..2009 /product="Arf family guanine nucleotide exchange factor SEC7" /calculated_mol_wt="226756" Region 272..1935 /region_name="PLN03076" /note="ARF guanine nucleotide exchange factor (ARF-GEF); Provisional" /db_xref="CDD:215560" CDS 1..2009 /gene="SEC7" /locus_tag="YDR170C" /coded_by="NM_001180477.3:1..6030" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9539714|PMID:10430582]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:12006663]" /experiment="EXISTENCE:direct assay:GO:0005798 Golgi-associated vesicle [PMID:1729652]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:1986005]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:1986005]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:20444982]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9473503]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:3042778]" /experiment="EXISTENCE:mutant phenotype:GO:0140455 cytoplasm protein quality control [PMID:37640758]" /note="Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors; involved in intra-Golgi transport, ER-to-Golgi transport and proliferation of the Golgi; role in directing misfolded proteins to insoluble deposition sites and detoxifying neurological disease proteins; found in the cytoplasm and on Golgi-associated coated vesicles" /db_xref="GeneID:851748" /db_xref="SGD:S000002577" ORIGIN 1 mseqnsvvna ekgdgeissn vetassvnps vkpqnaikee aketngedqk ckgpenagst 61 aetketsnda tngmktpeet edtndkrhdd egedgdeded ededededng deddedvdss 121 ssetssedge dsesvsgest esssgedees desdgntsns ssgdesgsee eeeeeeeeee 181 eenagepaia hqdsvptnds taprsthtrn islssngsnt nstiilvktt letilndkdi 241 kknsnaqkai ertlqkfkef dpqttnnphy vdsilvfeal rascrtkssk vqslaldcls 301 klfsfrslde tllvnppdsl asndqrqdaa dgitpppkqk iidaaidtis dcfqgegtdd 361 rvelqivral sscileedss slchgasllk airtiynvfv fslnpsnqgi aqatltqiis 421 svydkidlkq stssavslst knhqqqsaie lseasenaet papltlenmd klnddeerlm 481 daqqpdsiai tnqdlavkda flvfrvmaki cakpleteld mrshavrskl lslhiiysii 541 kdhidvflsh niflpgkerv cfidsirqyl rlvlsrnaas plapvfevtl eimwllianl 601 radfvkeipv flteiyfpis elttstsqqk ryflsviqri cndprtlvef ylnydcnpgm 661 pnvmeitvdy ltrlaltrve itqtqrsyyd eqiskslsty nfsqlpllts snlssspdvg 721 qvnllfpldf alkmvslnci vsvlrslssw ahkalnpnth tankvllntt ssarqesrss 781 lsndvrssim tsnddfkpty edeesrslss qnidaddptq fenlklrkta lseciaifnn 841 kpkkaipvli kkgflkddsp isiakwllet egldmaavgd ylgegddkni aimhafvdef 901 dftgmsivda lrsflqsfrl pgegqkidrf mlkfaerfvd qnpgvfskad tayvlsysli 961 mlntdlhssq iknkmslqef lennegidng rdlprdfleg lfneiannei kliseqhqam 1021 lsgdtnlvqq qqsafnffns rdltreaynq vskeisskte lvfknlnknk ggpdvyyaas 1081 hvehvksife tlwmsflaal tppfkdyddi dttnkclegl kisikiastf rindartsfv 1141 galvqfcnlq nleeikvknv namvilleva lsegnylegs wkdillvvsq merlqliskg 1201 idrdtvpdva qarvanprvs yessrsnnts ffdvwgkkat ptelaqekhh nqtlspeisk 1261 fissselvvl mdniftksse lsgnaivdfi kaltavslee iessenastp rmfslqkmvd 1321 vcyynmdrik lewtplwavm gkafnkiatn snlavvffai dslrqlsmrf ldieelsgfe 1381 fqhdflkpfe ytvqnsgnte vqemiiecfr nfiltksesi ksgwkpiles lqytarsste 1441 sivlktqllv sndivtnhfe nvfsqedafs elvgvfreit knkrfqklsl haleslrkmt 1501 qnvadicfyn enkteeerkh ndallrgkdi fqdvwfpmlf cfndtimtae dlevrsraln 1561 ymfdalvayg gkfnddfwek ickkllfpif gvlskhwevn qfnshddlsv wlsttliqal 1621 rnlialfthy feslnrmldg flgllvscic qendtiarig rsclqqlilq nvskfneyhw 1681 nqigdvfdkl fdlttanelf dydplqqgrk ssvshhqttn dtsqhsddds ndrrendsni 1741 setverahqe essedvggdm vetlngqtkl nngnsvptvk delnpkpasl sipkktkhmk 1801 rnesnedirr riniknsivv kcvlqllmie llnelfened fahcipykea iritrlleks 1861 yefsrdfned yglrtrlvea rvvdkipnll kqetsaaavl ldimfqlyln ddekkadlit 1921 rliticiqvv egyvslddrt mersinawrs viveilqgyy efddedfrly cpamyalviq 1981 ildksvptel rhaikqflsr vgelylstd // LOCUS NP_010455 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010455 VERSION NP_010455.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184320.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12012. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..440 /product="gag protein" /calculated_mol_wt="49314" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YDR170W-A" /coded_by="NM_001184320.1:1..1323" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /note="Retrotransposon TYA Gag gene; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag; YDR170W-A is part of a mutant retrotransposon; distribution in the cytoplasm becomes irregular rather than punctate upon DNA replication stress" /db_xref="GeneID:851750" /db_xref="SGD:S000007227" ORIGIN 1 mesqqlsqhs pishgsacas vtskevqttq dpldisaskt eecekvftqa nsqqpttpps 61 aavpenhhha spqaaqvplp qngpypqqrm mtpqqanisg wpvyghpslm pyppyqmspm 121 yappgaqsqf tqypqyvgth lntpspesgn sfpdsssaks nmtstnqhvr pppiltspnd 181 flnwvkiyik flqnsnlgdi iptatrkavr qmtddeltfl chtfqlfals qflptwvkdi 241 lsvdytdimk ilsksinkmq sdtqevndit tlanlhyngs tpadafeaev tnildrlknn 301 gipinnkvac qfimrglsge ykflryarhr yihmtvadlf sdihsmyeeq qeskrnksty 361 rrspsdekkd srtytnttkp ksitrnsqkp nnsqsrtara hnvstsnnfp gpdndlirgs 421 ttepiqlknk hdlhlrpgty // LOCUS NP_010456 375 aa linear PLN 30-JUN-2025 DEFINITION heat shock protein HSP42 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010456 VERSION NP_010456.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180478.1 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12013. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..375 /product="heat shock protein HSP42" /calculated_mol_wt="42686" Region 246..356 /region_name="IbpA" /note="Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]; COG0071" /db_xref="CDD:439841" CDS 1..375 /gene="HSP42" /locus_tag="YDR171W" /coded_by="NM_001180478.1:1..1128" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0007010 cytoskeleton organization [PMID:9199338]" /experiment="EXISTENCE:mutant phenotype:GO:0140311 protein sequestering activity [PMID:31649258]" /note="Compartment-specific sequestrase chaperone; small heat shock protein (sHSP) with chaperone activity; targets and sequesters proteins to cytoplasmic inclusions (CytoQ); sumoylated during DNA damage; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress" /db_xref="GeneID:851751" /db_xref="SGD:S000002578" ORIGIN 1 msfyqpslsl ydvlnalsnq tgqrgqqgyp rqpqrpqryh phygqvhvgg hhprhhplys 61 ryngvpntyy yqfpgqayyy speygydded geeedqdedm vgdsgttrqe dggedsnsrr 121 ypsyyhcnta rnnrtnqqan slndlltali gvppyegtep eieanteqeg ekgeekdkkd 181 kseapkeeag etnkekplnq leessrppla kksssfahlq apspipdplq vskpetrmdl 241 pfspevnvyd tedtyvvvla lpgansrafh idyhpsshem likgkiedrv gidekflkit 301 elkygafert vkfpvlprik deeikatynn gllqikvpki vndtekpkpk kriaieeipd 361 eelefeenpn ptven // LOCUS NP_010457 685 aa linear PLN 30-JUN-2025 DEFINITION translation termination factor GTPase eRF3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010457 VERSION NP_010457.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180479.3 REFERENCE 1 (residues 1 to 685) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 685) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 685) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 685) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12014. On Jul 30, 2012 this sequence version replaced NP_010457.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..685 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..685 /product="translation termination factor GTPase eRF3" /calculated_mol_wt="76420" Region <30..>199 /region_name="PRK10263" /note="DNA translocase FtsK; Provisional" /db_xref="CDD:236669" Region 254..685 /region_name="TEF1" /note="Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]; COG5256" /db_xref="CDD:444074" CDS 1..685 /gene="SUP35" /locus_tag="YDR172W" /gene_synonym="GST1; PNM2; SAL3; SUF12; SUP2; SUP36" /coded_by="NM_001180479.3:1..2058" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003747 translation release factor activity [PMID:20947765]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006415 translational termination [PMID:20947765]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23451152]" /experiment="EXISTENCE:direct assay:GO:0018444 translation release factor complex [PMID:7556078]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:8469113]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:12923185]" /note="Translation termination factor eRF3; has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion, self-perpetuating amyloid fibrils that modify cellular fitness, alter translational fidelity by affecting reading frame selection, and result in a nonsense suppressor phenotype; forms reversible liquid condensates in response to both acidic and osmotic stress to promote survival; many stress-response genes are repressed in the presence of [PSI(+)]" /db_xref="GeneID:851752" /db_xref="SGD:S000002579" ORIGIN 1 msdsnqgnnq qnyqqysqng nqqqgnnryq gyqaynaqaq paggyyqnyq gysgyqqggy 61 qqynpdagyq qqynpqggyq qynpqggyqq qfnpqggrgn yknfnynnnl qgyqagfqpq 121 sqgmslndfq kqqkqaapkp kktlklvsss giklanatkk vgtkpaesdk keeeksaetk 181 eptkeptkve epvkkeekpv qteekteeks elpkvedlki sesthntnna nvtsadalik 241 eqeeevddev vndmfggkdh vslifmghvd agkstmggnl lyltgsvdkr tiekyereak 301 dagrqgwyls wvmdtnkeer ndgktievgk ayfetekrry tildapghkm yvsemiggas 361 qadvgvlvis arkgeyetgf erggqtreha llaktqgvnk mvvvvnkmdd ptvnwskery 421 dqcvsnvsnf lraigynikt dvvfmpvsgy sganlkdhvd pkecpwytgp tlleyldtmn 481 hvdrhinapf mlpiaakmkd lgtivegkie sghikkgqst llmpnktave iqniyneten 541 evdmamcgeq vklrikgvee edispgfvlt spknpiksvt kfvaqiaive lksiiaagfs 601 cvmhvhtaie evhivkllhk lekgtnrksk kppafakkgm kviavletea pvcvetyqdy 661 pqlgrftlrd qgttiaigki vkiae // LOCUS NP_010458 355 aa linear PLN 30-JUN-2025 DEFINITION inositol polyphosphate multikinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010458 VERSION NP_010458.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180480.3 REFERENCE 1 (residues 1 to 355) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 355) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 355) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 355) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12015. On Jul 30, 2012 this sequence version replaced NP_010458.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..355 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..355 /product="inositol polyphosphate multikinase" /EC_number="2.7.1.151" /EC_number="2.7.1.127" /calculated_mol_wt="40222" Region 114..352 /region_name="IPK" /note="Inositol polyphosphate kinase; pfam03770" /db_xref="CDD:397715" CDS 1..355 /gene="ARG82" /locus_tag="YDR173C" /gene_synonym="ARGR3; IPK2" /coded_by="NM_001180480.3:1..1068" /experiment="EXISTENCE:direct assay:GO:0000823 inositol-1,4,5-trisphosphate 6-kinase activity [PMID:10720331|PMID:10574768]" /experiment="EXISTENCE:direct assay:GO:0000824 inositol-1,4,5,6-tetrakisphosphate 3-kinase activity [PMID:10720331|PMID:10574768]" /experiment="EXISTENCE:direct assay:GO:0000825 inositol-1,3,4,5-tetrakisphosphate 6-kinase activity [PMID:11311242]" /experiment="EXISTENCE:direct assay:GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity [PMID:11311242]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10720331|PMID:3311884]" /experiment="EXISTENCE:direct assay:GO:0016303 1-phosphatidylinositol-3-kinase activity [PMID:16123124]" /experiment="EXISTENCE:direct assay:GO:0032958 inositol phosphate biosynthetic process [PMID:10574768|PMID:11311242]" /experiment="EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:16123124]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12828642]" /experiment="EXISTENCE:mutant phenotype:GO:0000821 regulation of arginine metabolic process [PMID:2274024|PMID:8043104|PMID:11119723]" /experiment="EXISTENCE:mutant phenotype:GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity [PMID:10683435]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:10632874]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12828642]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:10632874]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:10632874]" /note="Inositol polyphosphate multikinase (IPMK); sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates genes responsive to arginine, phosphate, and nitrogen; needed by most [PSI+] variants for prion propagation" /db_xref="GeneID:851753" /db_xref="SGD:S000002580" ORIGIN 1 mdtvnnyrvl ehkaaghdgt ltdgdgllif kpafpqelef ykaiqvrdvs rrkssadgda 61 plcswmptyl gvlnegakie qsgdaallki derlsdstdn ldsipvksek skqylvlenl 121 lygfskpnil diklgktlyd skaslekrer mkrvsettts gslgfricgm kiqknpsvln 181 qlsleyyeee adsdyifink lygrsrtdqn vsdaielyfn nphlsdarkh qlkktflkrl 241 qlfyntmlee evrmisssll fiyegdperw ellndvdklm rddfiddddd dddndddddd 301 daegssegpk dkkttgslss mslidfahse itpgkgyden viegvetlld ifmkf // LOCUS NP_010459 246 aa linear PLN 30-JUN-2025 DEFINITION Hmo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010459 VERSION NP_010459.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180481.1 REFERENCE 1 (residues 1 to 246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 246) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12016. Method: conceptual translation. FEATURES Location/Qualifiers source 1..246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..246 /product="Hmo1p" /calculated_mol_wt="27413" Region 36..246 /region_name="NHP6B" /note="Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]; COG5648" /db_xref="CDD:227935" CDS 1..246 /gene="HMO1" /locus_tag="YDR174W" /gene_synonym="HSM2" /coded_by="NM_001180481.1:1..741" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:15507436|PMID:16533046]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:17646381|PMID:16612005]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:16533046|PMID:15507436]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12374750]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8969238]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:37432033]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:25063301]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:16533046|PMID:25063301|PMID:15507436]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:22553361]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:18451108]" /experiment="EXISTENCE:direct assay:GO:0051276 chromosome organization [PMID:25063301]" /experiment="EXISTENCE:genetic interaction:GO:0006356 regulation of transcription by RNA polymerase I [PMID:12374750]" /experiment="EXISTENCE:genetic interaction:GO:0060962 regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:18187511]" /experiment="EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:18187511]" /experiment="EXISTENCE:mutant phenotype:GO:0006265 DNA topological change [PMID:31969709]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:37432033]" /experiment="EXISTENCE:mutant phenotype:GO:0006356 regulation of transcription by RNA polymerase I [PMID:16612005]" /experiment="EXISTENCE:mutant phenotype:GO:0030261 chromosome condensation [PMID:27030801]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:31553911]" /experiment="EXISTENCE:mutant phenotype:GO:0060962 regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:18187511|PMID:17875934]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:35477092|PMID:31980450|PMID:31553911]" /note="Chromatin-associated high mobility group (HMG) family member; role in compacting, bending, bridging and looping DNA; lysine-rich CTD is essential for chromatin assembly, forming condensates with dsDNA; functionally similar to linker histone H1; rDNA-binding component regulates transcription from RNAPI promoters; regulates start site selection of ribosomal protein genes via RNAPII promoters; role in genome maintenance; associates with a 5'-3' DNA helicase and Fpr1p" /db_xref="GeneID:851754" /db_xref="SGD:S000002581" ORIGIN 1 mttdpsvklk sakdslvssl felskaanqt assivdfyna igddeeekie afttlteslq 61 tltsgvnhlh gisselvnpi dddkdaiiaa pvkavrrkie rdpnapkkpl tvffaysayv 121 rqelredrqk aglpplsste itqeiskkwk elsdnekekw kqaynvelen yqrekskyle 181 akkngtlppa slengpthap vpipfslqha aeppvekrph dddgssekkk kkkkkdkkkd 241 ksnssi // LOCUS NP_010460 319 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS35 RSM24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010460 VERSION NP_010460.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180482.1 REFERENCE 1 (residues 1 to 319) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 319) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 319) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 319) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12017. Method: conceptual translation. FEATURES Location/Qualifiers source 1..319 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..319 /product="mitochondrial 37S ribosomal protein mS35 RSM24" /calculated_mol_wt="37262" Region 171..299 /region_name="MRP-S28" /note="Mitochondrial ribosomal subunit protein; pfam10213" /db_xref="CDD:463002" CDS 1..319 /gene="RSM24" /locus_tag="YDR175C" /gene_synonym="mS35" /coded_by="NM_001180482.1:1..960" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:851755" /db_xref="SGD:S000002582" ORIGIN 1 mkvplglwkv srgnlwstqk rvltmsrcln sdagneaktv regpafsadl ymhpekwkgl 61 ppqrilelyw ermarlgsey kpnkdelnal lttseysnvp vndikklyhr geqgaidikg 121 gnvnrdnslr pfmfdelpsq aqelvaqhre qrfynrlaay elpllaqyrq eykrpspesh 181 pvtyrytsyv geehpnsrkv vlsvktkelg leekslhkfr ilarsrydht tdifkmssdk 241 fehasqnary lhdilqrlla eskdlteddf sdvpldtrht iakslrkkkr dyefpehwkr 301 pedapkkkfd ivdqllstl // LOCUS NP_010461 702 aa linear PLN 30-JUN-2025 DEFINITION histone acetyltransferase NGG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010461 VERSION NP_010461.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180483.3 REFERENCE 1 (residues 1 to 702) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 702) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 702) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 702) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12018. On Jul 30, 2012 this sequence version replaced NP_010461.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..702 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..702 /product="histone acetyltransferase NGG1" /calculated_mol_wt="79151" Region 506..648 /region_name="Ada3" /note="Histone acetyltransferases subunit 3; pfam10198" /db_xref="CDD:462993" CDS 1..702 /gene="NGG1" /locus_tag="YDR176W" /gene_synonym="ADA3; SWI7" /coded_by="NM_001180483.3:1..2109" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:11773077]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:direct assay:GO:0140671 ADA complex [PMID:7862114|PMID:10490601]" /note="Subunit of chromatin modifying histone acetyltransferase complexes; member of the ADA complex, the SAGA complex, and the SLIK complex; transcriptional regulator involved in glucose repression of Gal4p-regulated genes" /db_xref="GeneID:851756" /db_xref="SGD:S000002583" ORIGIN 1 mprhgrrgkl pkgeklpkke ggdntpskll ssmlktldlt ferdigmlng ksvrsipnkk 61 tllelqsqld slneilgtia rgdqetieal rkirdsknek qandekqets nadgqhesst 121 ateetniidk gvqsppkppp sneisgtien dvesikqaad nmakeeined kdlqvhrdqp 181 rekrpfdset enratenent qrpdnkkqki dvdkmendpt vknpksefvv sqtlpraaaa 241 lglfneegle stgedflkkk ynvasyptnd lkdllpgelp dmdfshpkpt nqiqfntfla 301 fvenffkdls ddnlkflkmk yiipdslqfd ktydpevnpf iipklgplyt dvwfkdendk 361 nsaykkpspy sndastilpk ksanelddna lesgsiscgp llsrllsavl kddndkselq 421 sskiirdggl prtggeddiq sfrnnnndtv dmtlsqengp svqtpdndid eeasfqakla 481 enkgsnggtt stlpqqigwi tnginldypt feerlkrelk yvgiymnlpk dennpnsddp 541 dwvtgredde isaelrelqg tlkqvtkknq krkaqliplv erqlawqeys siledldkqi 601 dqayvkrirv pkkrkkhhta asnnvntgtt sqiaqqkaan sslkslldkr qrwinkigpl 661 fdkpeimkri pnesvfkdmd qeededeadv faqntnkdve ln // LOCUS NP_010462 215 aa linear PLN 30-JUN-2025 DEFINITION E2 ubiquitin-conjugating protein UBC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010462 VERSION NP_010462.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180484.3 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12019. On Jul 30, 2012 this sequence version replaced NP_010462.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..215 /product="E2 ubiquitin-conjugating protein UBC1" /EC_number="2.3.2.23" /calculated_mol_wt="24047" Region 4..147 /region_name="UBCc_UBE2K" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 K and related proteins; cd23800" /db_xref="CDD:467420" Region 161..215 /region_name="UBA_3" /note="Fungal ubiquitin-associated domain; pfam09288" /db_xref="CDD:117832" Site order(178..181,207,210) /site_type="other" /note="putative polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270496" CDS 1..215 /gene="UBC1" /locus_tag="YDR177W" /coded_by="NM_001180484.3:1..648" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:2265617]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:10848595]" /experiment="EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:2265617]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:10878801]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:2265617|PMID:11134048]" /experiment="EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:11134048]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:10878801]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]" /note="Ubiquitin-conjugating enzyme; key E2 partner with Ubc4p for the anaphase-promoting complex (APC); mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress key E2 partner with Ubc4p for the anaphase-promoting complex (APC)" /db_xref="GeneID:851757" /db_xref="SGD:S000002584" ORIGIN 1 msrakrimke iqavkddpaa hitlefvses dihhlkgtfl gppgtpyegg kfvvdievpm 61 eypfkppkmq fdtkvyhpni ssvtgaicld ilknawspvi tlksalislq allqspepnd 121 pqdaevaqhy lrdresfnkt aalwtrlyas etsngqkgnv eesdlygidh dlidefesqg 181 fekdkivevl rrlgvksldp ndnntanrii eellk // LOCUS NP_010463 181 aa linear PLN 30-JUN-2025 DEFINITION succinate dehydrogenase membrane anchor subunit SDH4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010463 VERSION NP_010463.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180485.1 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12020. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..181 /product="succinate dehydrogenase membrane anchor subunit SDH4" /calculated_mol_wt="20118" Region 36..167 /region_name="CybS" /note="succinate dehydrogenase cytochrome B small subunit; pfam05328" /db_xref="CDD:461624" CDS 1..181 /gene="SDH4" /locus_tag="YDR178W" /gene_synonym="ACN18" /coded_by="NM_001180485.1:1..546" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0045273 respiratory chain complex II (succinate dehydrogenase) [PMID:8120006]" /experiment="EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:18028869]" /experiment="EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:16232921]" /note="Membrane anchor subunit of succinate dehydrogenase (SDH); involved in coupling the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; has similarity to human SDH subunit D (SDHD), which is implicated in paraganglioma" /db_xref="GeneID:851758" /db_xref="SGD:S000002585" ORIGIN 1 mmlprsmkfm tgrrifhtat vrafqstakk sltipflpvl pqkpggvrgt pndayvpppe 61 nklegsyhwy mekifalsvv plattamltt gplstaadsf fsvmllgycy mefnscitdy 121 iservygvwh kyamymlglg savslfgiyk letendgvvg lvkslwdsse kdnsqkieak 181 k // LOCUS NP_010464 162 aa linear PLN 30-JUN-2025 DEFINITION Csn9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010464 VERSION NP_010464.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180486.1 REFERENCE 1 (residues 1 to 162) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 162) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 162) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 162) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12021. Method: conceptual translation. FEATURES Location/Qualifiers source 1..162 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..162 /product="Csn9p" /calculated_mol_wt="19345" CDS 1..162 /gene="CSN9" /locus_tag="YDR179C" /coded_by="NM_001180486.1:1..489" /experiment="EXISTENCE:direct assay:GO:0008180 COP9 signalosome [PMID:12446563]" /experiment="EXISTENCE:mutant phenotype:GO:0000338 protein deneddylation [PMID:12446563|PMID:12186635]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:12446563]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:12446563]" /note="Subunit of the Cop9 signalosome; Cop9 signalosome is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling" /db_xref="GeneID:851759" /db_xref="SGD:S000002586" ORIGIN 1 mvmreetiks ledpykyhyk eewlntkdpd eqqlfeifaf gnikdlpeni iltslmrskl 61 ekltlvtlse iynelsyeli keecqieddg iieshliqlq nifkaemdsv sksmkfsrrf 121 dcrdvychek eltiiknprv tkeylvqnlr swetklkqni le // LOCUS NP_010465 463 aa linear PLN 30-JUN-2025 DEFINITION Nvj3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010465 VERSION NP_010465.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180487.3 REFERENCE 1 (residues 1 to 463) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 463) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 463) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 463) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12022. On Jul 30, 2012 this sequence version replaced NP_010465.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..463 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..463 /product="Nvj3p" /calculated_mol_wt="53599" Region 98..246 /region_name="PXA" /note="PXA domain; pfam02194" /db_xref="CDD:460484" CDS 1..463 /gene="NVJ3" /locus_tag="YDR179W-A" /coded_by="NM_001180487.3:1..1392" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:26283797]" /note="Protein with a potential role in tethering ER and vacuoles; localizes to nucleus-vacuole junctions in an Mdm1p-dependent manner; contains a lipid-binding PXA domain" /db_xref="GeneID:851760" /db_xref="SGD:S000002587" ORIGIN 1 mptilyntns slitkyrrpn asnqykgfls kkghtrlnsk ssgdiwekdc shtknsgndv 61 sfesefekds veylrdlcfs iypnslhqki rsiealpdlq vntfialifq nfvkswygik 121 iptddskflt elynlvqdli tylksskiny hallldyipc llsshlkaln dssqnndlvy 181 eqyckltlyd skrypmlfte iiqskmstks llqrsfldsf lnelvfghif nsiaepyyll 241 eglnkiciri klnsagntrn evthgkpkcd pwlfvsnvkh kilqmtrlla yststeaanm 301 ntaeiqetaf lqryiftfft ddffklsmrk pflfsicrtl qhwisklnal nrvmyrtfdn 361 ivqtkitspv tignlfsllr hslfpndnmm gpprvlpvgd aflefreeci snlwdvcmty 421 kldhilaikr sdiadliici sknrdcnkll iyriidcvia qlp // LOCUS NP_010466 1493 aa linear PLN 30-JUN-2025 DEFINITION cohesin-loading factor complex subunit SCC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010466 VERSION NP_010466.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180488.3 REFERENCE 1 (residues 1 to 1493) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1493) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1493) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1493) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12023. On Jul 30, 2012 this sequence version replaced NP_010466.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1493 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1493 /product="cohesin-loading factor complex subunit SCC2" /calculated_mol_wt="170971" Region 249..1435 /region_name="SCC2" /note="Sister chromatid cohesion protein 2 and homologs; cd23958" /db_xref="CDD:467937" CDS 1..1493 /gene="SCC2" /locus_tag="YDR180W" /coded_by="NM_001180488.3:1..4482" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:9990856]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005729 2-micrometer circle DNA [PMID:17670945]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0043515 kinetochore binding [PMID:28938124]" /experiment="EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:19948494]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:15610741|PMID:11448778|PMID:15610742]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:18708580|PMID:19948494]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:10882066]" /experiment="EXISTENCE:mutant phenotype:GO:0070058 tRNA gene clustering [PMID:19948494]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:18708580]" /experiment="EXISTENCE:mutant phenotype:GO:0071168 protein localization to chromatin [PMID:16793545|PMID:18708580]" /experiment="EXISTENCE:mutant phenotype:GO:0071169 establishment of protein localization to chromatin [PMID:10882066]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:16888651]" /experiment="EXISTENCE:physical interaction:GO:0032116 SMC loading complex [PMID:10882066]" /note="Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2; conserved role in NHEJ" /db_xref="GeneID:851761" /db_xref="SGD:S000002588" ORIGIN 1 msypgkdkni pgriiealed lplsylvpkd glaalvnapm rvslpfdkti ftsaddgrdv 61 ninvlgtans ttssikneae kerlvfkrps nftssansvd yvptnflegl splaqsvlst 121 hkglndsini ekkseivsrp eakhklesvt snagnlsfnd nssnkktkts tgvtmtqanl 181 aeqylndlkn ildivgfdqn saeignieyw lqlpnkkfvl ttncltklqm tiknitdnpq 241 lsnsieitwl lrlldvmvcn ikfsksslkm glddsmlryi allstivlfn ifllgkndsn 301 lhresyimep vnflsdlies lkiltieygs lkiefdtfqe alellpkyir ngpflddnvt 361 aklvyifsdl lmnndieatt niqfqsfwdn vkrissdilv slfgsfdqqr gfiieellsh 421 ieklptkriq kklrkvgnqn iyitdftftl msmlenincy sfcnqmkdia penidllkne 481 ykkqeeflfn ivehindtil erffknpsal ryvidnfvqd llllisspqw pvtekilssl 541 lkrllsvysp smqvsaniet iclqlignig stifdikcst rdhednnlik minypetlph 601 ffksfeecia ynetikcrrs atrflwnlrl gtilileeyt kdakeqiitv dnelkkileq 661 ikdgglgpel enreadfsti kldyfsilha fellnlydpy lklilsllak dkiklrstai 721 kclsmlaskd kvilsnpmvk etihrrlnds sasvkdaild lvsinssyfe fyqqinnnyn 781 ddsimvrkhv lrinekmyde tndivtkvyv iarilmkied eedniidmar lillnrwilk 841 vhevldqpek lkeisssvll vmsrvaimne kcsqlfdlfl nfyllnkeah skeaydkith 901 vltiltdflv qkivelnsdd tneknsivdk qnflnllakf adstvsfltk dhitalypym 961 vsdeksdfhy yilqvfrctf eklanfkqkf lydlettlls rlpkmnvrei deampliwsv 1021 athrhdtarv akacssclsh lhpyinkann eeaaivvdgk lqrliylstg farfcfpkps 1081 ndkiaflqeg etlyehitkc llvlskdkit hvirrvavkn ltklcgnhpk lfnsrhvlhl 1141 ldkefqsdql diklvilesl ydlflleerk svrntgvnst lssnsilkkk llktnrvefa 1201 ndgvcsalat rfldnilqlc llrdlknslv airllklilk fgytnpshsi ptvialfast 1261 sqyirhvaye lledlfekye tlvfsslsrg vtkaihysih tdekyyykhd hflslleklc 1321 gtgkkngpkf fkvlkrimqs yldditdlts tnssvqksif vlctnisnit fvsqydlvsl 1381 lktidlttdr lkevimdeig dnvsslsvse eklsgiiliq lslqdlgtyl lhlyglrddv 1441 llldiveese lknkqlpakk pdiskfsaql enieqyssng klltyfrkhv kdt // LOCUS NP_010467 481 aa linear PLN 30-JUN-2025 DEFINITION Sas4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010467 VERSION NP_010467.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180489.1 REFERENCE 1 (residues 1 to 481) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 481) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 481) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 481) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12024. Method: conceptual translation. FEATURES Location/Qualifiers source 1..481 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..481 /product="Sas4p" /calculated_mol_wt="55279" Region 124..222 /region_name="SAS4" /note="Something about silencing, SAS, complex subunit 4; pfam15460" /db_xref="CDD:464730" CDS 1..481 /gene="SAS4" /locus_tag="YDR181C" /coded_by="NM_001180489.1:1..1446" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:11731479]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:12626510]" /experiment="EXISTENCE:direct assay:GO:0016407 acetyltransferase activity [PMID:11731479]" /experiment="EXISTENCE:direct assay:GO:0031509 subtelomeric heterochromatin formation [PMID:11731479]" /experiment="EXISTENCE:direct assay:GO:0033255 SAS acetyltransferase complex [PMID:12626510]" /note="Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p" /db_xref="GeneID:851762" /db_xref="SGD:S000002589" ORIGIN 1 mgifqsieea nntserllrs eiknshgefe kfdfdteeye inpkrklrlv srinpnaghl 61 rkskscftvd ehvdetrcqk pvmkspfmsn vddeikkkre titkmtleie hhelsqnirk 121 ptddllpdst yqpyhkkmlk qenrmiqsdi vngeneadrl slisdrlgml nwevtlqkvt 181 kindptdene metkryqtke lidsmlhkfe smkkksrnla rrpassdsll klvsgkdwpk 241 iytridrtfi pdyasssdee eekitveeir errlkkreqq cggsiivlls dhqsqkgmtr 301 faivaeplrk pyliktstke rnswknkvpt npkkfkkapr istqiavkrr revipltmev 361 epevirdirq dtqksmklnv kaeeisvtet vkskemnalr nnaasisptl sekaplgsis 421 sctasqisqr ssenvgaiin ninpnlaivp scnektfvkt hngmktnsgi nilpvrkkkk 481 v // LOCUS NP_010468 491 aa linear PLN 30-JUN-2025 DEFINITION putative lipid phosphatase CDC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010468 VERSION NP_010468.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180490.1 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12025. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..491 /product="putative lipid phosphatase CDC1" /calculated_mol_wt="57016" Region 91..347 /region_name="MPP_Cdc1" /note="Saccharomyces cerevisiae CDC1 and related proteins, metallophosphatase domain; cd08163" /db_xref="CDD:277370" Site order(95,97,144,183..184,259,314,316) /site_type="active" /note="putative active site [active]" /db_xref="CDD:277370" Site order(95,97,144,183,259,314,316) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:277370" CDS 1..491 /gene="CDC1" /locus_tag="YDR182W" /gene_synonym="DSC1; DSR1; ESP2" /coded_by="NM_001180490.1:1..1476" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:18332110]" /experiment="EXISTENCE:genetic interaction:GO:0006506 GPI anchor biosynthetic process [PMID:25165136]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:7969142]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:33112703]" /note="Putative mannose-ethanolamine phosphate phosphodiesterase; involved in GPI-anchor remodeling prior to the attachment of cell wall proteins to beta 1,3-glucan, removing ethanolamine phosphate from the first mannose of GPI anchors; mutants display elevated Ca2+-dependent signaling resulting in secondary actin polarization and Golgi inheritance defects; enzyme is Mn2+-dependent; mutants have cell division cycle defect and fragile cell walls" /db_xref="GeneID:851763" /db_xref="SGD:S000002590" ORIGIN 1 mvyrnrsksv lsthskksdd kahyksrskk ksksrskkrl riywryisiv wilwlglisy 61 yesvvvkram kkcqwstwed wpegaeshrv glfadpqimd eysypgrpqi vnyftrvivd 121 hyhrrnwkyv qyyldpdsnf flgdlfdggr nwddkqwike ytrfnqifpk kplrrtvmsl 181 pgnhdigfgd tvvesslqrf ssyfgetsss ldagnhtfvl ldtislsdkt npnvsrvprq 241 fldnfamgsh plprillthv plwrdpeqqt cgqlreskep fpiqkghqyq tviendisqe 301 iltkiqpeil fsgddhdhcq ishsypfqgk tknaqeitvk scamnmgisr paiqllslyn 361 psdltmvnag geyasktyqt elcympdpyk airmylwgll fsaafiaymh ffpksfnnrv 421 atimnrvftr pdgntsdlpl ptsisksksk kslthskyav ndtrsikqfl vnaivlfvsv 481 mpifiyfytv v // LOCUS NP_878063 67 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR182W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878063 VERSION NP_878063.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184545.3 REFERENCE 1 (residues 1 to 67) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 67) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 67) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 67) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12026. On Jul 30, 2012 this sequence version replaced NP_878063.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..67 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..67 /product="uncharacterized protein" /calculated_mol_wt="7542" Region <27..67 /region_name="SBF" /note="Sodium Bile acid symporter family; cl19217" /db_xref="CDD:450274" CDS 1..67 /locus_tag="YDR182W-A" /coded_by="NM_001184545.3:1..204" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466434" /db_xref="SGD:S000028539" ORIGIN 1 mnkryklyrv wyyyahqtvc itstgfalcf vvqaktaglg vtpitslygd kkehlgkllv 61 plvlyqi // LOCUS NP_010469 230 aa linear PLN 30-JUN-2025 DEFINITION Plp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010469 VERSION NP_010469.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180491.3 REFERENCE 1 (residues 1 to 230) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 230) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 230) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 230) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12027. On Jul 30, 2012 this sequence version replaced NP_010469.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..230 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..230 /product="Plp1p" /calculated_mol_wt="26492" Region 80..192 /region_name="Phd_like_TxnDC9" /note="Phosducin (Phd)-like family, Thioredoxin (TRX) domain containing protein 9 (TxnDC9) subfamily; composed of predominantly uncharacterized eukaryotic proteins, containing a TRX-like domain without the redox active CXXC motif. The gene name for the human...; cd02989" /db_xref="CDD:239287" CDS 1..230 /gene="PLP1" /locus_tag="YDR183W" /coded_by="NM_001180491.3:1..693" /experiment="EXISTENCE:direct assay:GO:0031683 G-protein beta/gamma-subunit complex binding [PMID:10749875]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:16415341]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10749875]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:10749875]" /note="Protein that interacts with CCT (chaperonin containing TCP-1) complex; has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators" /db_xref="GeneID:851764" /db_xref="SGD:S000002591" ORIGIN 1 medkldryyt nvlsnaekdk httvdsddks sgeenldell neldrelded heflsayrse 61 rlqqisdhlk qvkknveddg ygrlqcidne adaiqictkt tmvvihfele tfgkcqymne 121 klenlakryl ttrfikvnvq tcpflvnkln ikvlpfvvgy knglekvryv gfsklgndpn 181 gfdirrleqs lahsgviedt feirkhssvn terfastnhd rsesdsdldi // LOCUS NP_010470 294 aa linear PLN 30-JUN-2025 DEFINITION Atc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010470 VERSION NP_010470.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180492.1 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12028. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..294 /product="Atc1p" /calculated_mol_wt="32983" CDS 1..294 /gene="ATC1" /locus_tag="YDR184C" /gene_synonym="LIC4" /coded_by="NM_001180492.1:1..885" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10102375|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:11065362]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:10102375]" /note="Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress" /db_xref="GeneID:851765" /db_xref="SGD:S000002592" ORIGIN 1 mntnqsnpnt dltddanieh tlhrlltqan nhfddtvkid gqsldlgkdl eqvmmdnldc 61 tdifdsdias qkhltleslf ndehntdsst llemqrsand slvgidldrh kkgytgkasl 121 dkstnqnnvh kpdkeqknyk idkptikkkk sllkttnepm lspaslspss slassdanes 181 hlkiesmitd itskidsarq divsatkpak ftneftisqi semkariint hklllnfnfi 241 kegyarsciq lkksmdslkd seihrahllv enddlkqqil eltqklneks skes // LOCUS NP_010471 179 aa linear PLN 30-JUN-2025 DEFINITION Ups3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010471 VERSION NP_010471.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180493.1 REFERENCE 1 (residues 1 to 179) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 179) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 179) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 179) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12029. Method: conceptual translation. FEATURES Location/Qualifiers source 1..179 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..179 /product="Ups3p" /calculated_mol_wt="20790" Region 15..171 /region_name="PRELI" /note="PRELI-like family; pfam04707" /db_xref="CDD:398400" CDS 1..179 /gene="UPS3" /locus_tag="YDR185C" /gene_synonym="GEP2" /coded_by="NM_001180493.1:1..540" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:19506038]" /experiment="EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:19506038]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:19506038]" /note="Mitochondrial hypothetical protein; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations; UPS3 has a paralog, UPS2, that arose from the whole genome duplication" /db_xref="GeneID:851766" /db_xref="SGD:S000002593" ORIGIN 1 mksfqksyef dypwekvtta nwmkypnkis thviavdvlr relkehgdvl lterlitirq 61 ntphwmsilv gntnlayvre vstvdrrdrs ltmrscnmtf philkcyetv ryvphpknps 121 nvtlfkqdak flsgvptktf sekvenwgvk rfsdnavkgk vgfdsilamf ndiwknane // LOCUS NP_010472 877 aa linear PLN 30-JUN-2025 DEFINITION Snd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010472 VERSION NP_010472.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180494.3 REFERENCE 1 (residues 1 to 877) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 877) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 877) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 877) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 877) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 877) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 877) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 877) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 877) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12030. On Jul 30, 2012 this sequence version replaced NP_010472.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..877 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..877 /product="Snd1p" /calculated_mol_wt="98200" CDS 1..877 /gene="SND1" /locus_tag="YDR186C" /coded_by="NM_001180494.3:1..2634" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Env10p/Snd2p and Pho88p/Snd3p; can compensate for loss of SRP; co-purifies with ribosomes; GFP-fusion protein localizes to the cytoplasm" /db_xref="GeneID:851767" /db_xref="SGD:S000002594" ORIGIN 1 mdtvgtdaaa asinerrfaq stspkvsvks qdslflitys nmqqtvvqas ladrypslkk 61 lnillyidip tidyyndemt hnklsrlnkr fklhrlrnsi aqsfsntsta edndkfweel 121 kslissrstp enkfdlnvlv sssgslryve tirflveklf nsfkdlyvqk klnlcfqinv 181 sptslkwfst flnaellnlk iinwqnigsf tktiqnsksl pfkeyytkln ekftgsnqsn 241 gsmqdqtvld sivivtnstg vkalltllsd hpltslisqe sikalheysd avnedkgddq 301 sntslkrnss sllnfqnsvl tsnkdksvri rslsinrksn rahmfktnes ittipstsin 361 nligqesnlr kqpsgtalhl qshlhphsrs qsysssnmsr spspfpygkt psndelvyde 421 lnnqinevqd rakneeivly nnnnyddytk ergeqeqdrt syadeygfny ddeeggnedn 481 ydddeddddd dddddesdde glsfyapsil srsgsstdvl ssgidsmakn sketrgrfrs 541 lslmdpalqk pfnqkfpnsq qpdsagassp krstssnhft nvyvhdgdfd gtdtinnkkn 601 lssatlikrk slmnrnlaps isnglippef isristpsts asssnsslnd mstvsnafsk 661 llndtskkqk flnspipqht qqaspllmrn nsnsnllfek nlinksfeel rrqpsvnlfs 721 tlmngnmekn glalnfksrt ptdalmansi knsnnsshrl lnleeedqim sgslpkered 781 dndstnstiv pnhpdndnyn dndndnntgi nsnnfnlnly ddndsagftd vttegvkysn 841 snstvtkpvy kkavtldlyg eddmdnmggw vlggnar // LOCUS NP_010474 546 aa linear PLN 30-JUN-2025 DEFINITION chaperonin-containing T-complex subunit CCT6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010474 VERSION NP_010474.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180496.3 REFERENCE 1 (residues 1 to 546) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 546) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 546) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 546) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12031. On Jul 30, 2012 this sequence version replaced NP_010474.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..546 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..546 /product="chaperonin-containing T-complex subunit CCT6" /calculated_mol_wt="59793" Region 2..542 /region_name="chap_CCT_zeta" /note="T-complex protein 1, zeta subunit; TIGR02347" /db_xref="CDD:274088" CDS 1..546 /gene="CCT6" /locus_tag="YDR188W" /gene_synonym="HTR3; TCP20; TCP6" /coded_by="NM_001180496.3:1..1641" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /note="Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif" /db_xref="GeneID:851768" /db_xref="SGD:S000002596" ORIGIN 1 mslqllnpka eslrrdaalk vnvtsaeglq svletnlgpk gtlkmlvdga gnikltkdgk 61 vlltemqiqs ptavliaraa aaqdeitgdg tttvvclvge llrqahrfiq egvhpriitd 121 gfeiarkesm kfldefkisk tnlsndrefl lqvarssllt kvdadltevl tpivtdavls 181 vydaqadnld lhmveimqmq hlspkdttfi kglvldhggr hpdmptrvkn ayvlilnvsl 241 eyektevnsg ffyssadqrd klaaserkfv daklkkiidl knevcgmdpd kgfviinqkg 301 idpmsldvfa khnilalrra krrnmerlql vtggeaqnsv edlspqilgf sglvyqetig 361 eekftyvten tdpksctili kgsthyalaq tkdavrdglr avanvlkdkn iipgagafyi 421 alsrylrsan mnklgakgkt ktgieafaea llvipktlvk nsgfdpldvl amvedeldda 481 qdsdetryvg vdlnigdscd ptiegiwdsy rvlrnaitga tgiasnlllc dellragrst 541 lketpq // LOCUS NP_010475 666 aa linear PLN 30-JUN-2025 DEFINITION syntaxin-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010475 VERSION NP_010475.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180497.1 REFERENCE 1 (residues 1 to 666) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 666) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 666) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 666) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12032. Method: conceptual translation. FEATURES Location/Qualifiers source 1..666 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..666 /product="syntaxin-binding protein" /calculated_mol_wt="74548" Region 11..661 /region_name="SEC1" /note="Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion]; COG5158" /db_xref="CDD:227487" CDS 1..666 /gene="SLY1" /locus_tag="YDR189W" /coded_by="NM_001180497.1:1..2001" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:15372079]" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:15958490]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10747087]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0019905 syntaxin binding [PMID:12186954|PMID:15372079]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:10747087]" /experiment="EXISTENCE:genetic interaction:GO:0005783 endoplasmic reticulum [PMID:15958490]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9545229]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:15958490]" /experiment="EXISTENCE:mutant phenotype:GO:0019905 syntaxin binding [PMID:12186954]" /experiment="EXISTENCE:mutant phenotype:GO:0035543 positive regulation of SNARE complex assembly [PMID:12186954]" /experiment="EXISTENCE:mutant phenotype:GO:0048280 vesicle fusion with Golgi apparatus [PMID:8636207]" /note="Hydrophilic protein involved in ER/Golgi vesicle trafficking; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex" /db_xref="GeneID:851770" /db_xref="SGD:S000002597" ORIGIN 1 maveeiasrk dislrdmqis ailkmlflnk dlnnndnitt itddifnqqe iiwkvlildi 61 kstatissvl rvndllkagi tvhslikqdr splpdvpaiy fvsptkenid iivndlksdk 121 ysefyinfts slprnlledl aqqvsitgks dkikqvydqy ldfivtepel fsleisnayl 181 tlndpkttee eitglcania dglfntvlti nsipiiraak ggpaeiiaek lgtklrdfvi 241 ntnssststl qgndslergv liildrnidf asmfshswiy qcmvfdifkl srntvtiple 301 skengtdntt akplatkkyd iepndffwme nshlpfpeaa enveaalnty keeaaeitrk 361 tgvtnisdld pnsnndtvqi qevvkklpel takkntidth mnifaallsq lesksldtff 421 eveqdpgstk trsrfldilk dgktnnledk lrsfivlylt sttglpkdfv qnvenyfken 481 dydinalkyv yklrefmqls nmslqnksle dgsdsafkps nltlsgiygl tegklqggvg 541 slisgikkll pekktipitn vvdaimdpln ssqknlettd sylyidpkit rgshtrkpkr 601 qsynkslvfv vgggnyleyq nlqewahsql hnpkkvmygs taittpaefl neisrlgasn 661 ssnnda // LOCUS NP_010476 463 aa linear PLN 30-JUN-2025 DEFINITION RuvB family ATP-dependent DNA helicase pontin [Saccharomyces cerevisiae S288C]. ACCESSION NP_010476 VERSION NP_010476.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180498.1 REFERENCE 1 (residues 1 to 463) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 463) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 463) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 463) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12033. Method: conceptual translation. FEATURES Location/Qualifiers source 1..463 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..463 /product="RuvB family ATP-dependent DNA helicase pontin" /EC_number="3.6.4.12" /calculated_mol_wt="50322" Region 23..378 /region_name="TIP49" /note="TIP49 P-loop domain; pfam06068" /db_xref="CDD:399217" Region 383..448 /region_name="TIP49_C" /note="TIP49 AAA-lid domain; pfam17856" /db_xref="CDD:436097" CDS 1..463 /gene="RVB1" /locus_tag="YDR190C" /gene_synonym="TIH1; TIP49; TIP49A" /coded_by="NM_001180498.1:1..1392" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:16299513]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:10952318]" /experiment="EXISTENCE:direct assay:GO:0043139 5'-3' DNA helicase activity [PMID:18234224]" /experiment="EXISTENCE:direct assay:GO:0097255 R2TP complex [PMID:15766533]" /experiment="EXISTENCE:direct assay:GO:0110078 TTT Hsp90 cochaperone complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:18268103]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11278922]" /experiment="EXISTENCE:physical interaction:GO:0000812 Swr1 complex [PMID:14645854|PMID:14690608]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:14690608]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245|PMID:10952318]" /experiment="EXISTENCE:physical interaction:GO:0097255 R2TP complex [PMID:18268103]" /note="ATP-dependent DNA helicase, also known as pontin; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, the R2TP complex (Rvb1-Rvb2-Tah1-Pih1), and the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly; member of the AAA+ and RuvB-like protein families, similar to Rvb2p" /db_xref="GeneID:851771" /db_xref="SGD:S000002598" ORIGIN 1 mvaisevken pgvnssnsga vtrtaahthi kglgldesgv akrveggfvg qieareacgv 61 ivdlikakkm sgraillagg pstgktalal aisqelgpkv pfcplvgsel ysvevkktet 121 lmenfrraig lriketkevy egevteltpe daenplggyg ktishvivgl ksakgtktlr 181 ldptiyesiq rekvsigdvi yieantgavk rvgrsdayat efdleteeyv plpkgevhkk 241 keivqdvtlh dldvanarpq ggqdvismmg qllkpkktei teklrqevnk vvakyidqgv 301 aelipgvlfi devnmldiei ftylnkales niapvvvlas nrgmttvrgt edvisphgvp 361 pdlidrlliv rtlpydkdei rtiierratv erlqvessal dllatmgtet slryalqlla 421 pcgilaqtsn rkeivvndvn eakllfldak rstkiletsa nyl // LOCUS NP_010477 370 aa linear PLN 30-JUN-2025 DEFINITION NAD-dependent histone deacetylase HST4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010477 VERSION NP_010477.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180499.3 REFERENCE 1 (residues 1 to 370) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 370) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 370) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 370) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12034. On Jul 30, 2012 this sequence version replaced NP_010477.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..370 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..370 /product="NAD-dependent histone deacetylase HST4" /EC_number="2.3.1.286" /calculated_mol_wt="41634" Region 93..362 /region_name="SIR2" /note="SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; cl00195" /db_xref="CDD:444738" CDS 1..370 /gene="HST4" /locus_tag="YDR191W" /coded_by="NM_001180499.3:1..1113" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26158509|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:26158509]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26158509]" /experiment="EXISTENCE:direct assay:GO:0006351 DNA-templated transcription [PMID:31167142]" /experiment="EXISTENCE:direct assay:GO:0009299 mRNA transcription [PMID:31167142]" /experiment="EXISTENCE:direct assay:GO:0017136 histone deacetylase activity, NAD-dependent [PMID:21401809]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:7498786]" /experiment="EXISTENCE:mutant phenotype:GO:0046459 short-chain fatty acid metabolic process [PMID:12618394]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3" /db_xref="GeneID:851772" /db_xref="SGD:S000002599" ORIGIN 1 mkqkfvlpit ppstaekkpq tenrcnenlk prrllpqlkk svrnrkprls yrpelnsvfd 61 ldayvdsthl sksqrhhmdr dagfisyaln yskrmvvvsg agisvaagip dfrssegifs 121 tvnggsgkdl fdynrvygde smslkfnqlm vslfrlsknc qptkfhemln efardgrllr 181 lytqnidgld tqlphlstnv plakpipstv qlhgsikhme cnkclnikpf dpelfkcddk 241 fdsrteiips cpqceeyetv rkmaglrstg vgklrprvil ynevhpegdf igeianndlk 301 kridcliivg tslkipgvkn icrqfaakvh anrgivlyln tsmppknvld slkfvdlvvl 361 gdcqhvtsll // LOCUS NP_010478 430 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin NUP42 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010478 VERSION NP_010478.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180500.3 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12035. On Jul 30, 2012 this sequence version replaced NP_010478.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..430 /product="FG-nucleoporin NUP42" /calculated_mol_wt="42647" Region <2..>380 /region_name="FhaB" /note="Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]; COG3210" /db_xref="CDD:442443" CDS 1..430 /gene="NUP42" /locus_tag="YDR192C" /gene_synonym="RIP1; UIP1" /coded_by="NM_001180500.3:1..1293" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:7634338|PMID:10684247|PMID:10610322]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:10684247|PMID:10610322]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]" /experiment="EXISTENCE:genetic interaction:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:10952996]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:11387327]" /experiment="EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479|PMID:20098417]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:9353254|PMID:18258809|PMID:9353255]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17803941|PMID:17418788]" /note="FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p; human homolog NUP42 can complement yeast mutant" /db_xref="GeneID:851774" /db_xref="SGD:S000002600" ORIGIN 1 msafgnpfts gakpnlsnts ginpftnnaa stnnmggsaf grpsfgtant mtggtttsaf 61 gmpqfgtntg ntgntsisaf gntsnaakps afgapafgss apinvnppst tsafgapsfg 121 stgfgamaat snpfgkspgs mgsafgqpaf ganktaipss svsnsnnsaf gaasntpltt 181 tspfgslqqn asqnasstss afgkptfgaa tntqspfgti qntstssgtg vspfgtfgtn 241 snnkspfsnl qsgagagssp fgtttskann nnnvgssafg ttnnqspfsg gsggtfgsas 301 nlnkntngnf qssfgnkgfs fgitpqndan kvsqsnpsfg qtmpntdpni slksngnats 361 fgfgqqqmna tnvnantatg kirfvqglss ekdgilelad laeetlkifr ankfelglvp 421 dippppalva // LOCUS NP_010480 664 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010480 VERSION NP_010480.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180502.1 REFERENCE 1 (residues 1 to 664) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 664) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 664) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 664) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12036. Method: conceptual translation. FEATURES Location/Qualifiers source 1..664 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..664 /product="ATP-dependent RNA helicase" /EC_number="3.6.4.13" /calculated_mol_wt="76138" Region 113..525 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..664 /gene="MSS116" /locus_tag="YDR194C" /coded_by="NM_001180502.1:1..1995" /experiment="EXISTENCE:direct assay:GO:0000373 Group II intron splicing [PMID:17081564]" /experiment="EXISTENCE:direct assay:GO:0002151 G-quadruplex RNA binding [PMID:30855040]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:17081564]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:17081564]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005761 mitochondrial ribosome [PMID:28520979]" /experiment="EXISTENCE:direct assay:GO:0006392 transcription elongation by mitochondrial RNA polymerase [PMID:24732805]" /experiment="EXISTENCE:direct assay:GO:0033592 RNA strand annealing activity [PMID:17081564]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:30855040]" /experiment="EXISTENCE:direct assay:GO:0070124 mitochondrial translational initiation [PMID:28520979]" /experiment="EXISTENCE:direct assay:GO:0070125 mitochondrial translational elongation [PMID:28520979]" /experiment="EXISTENCE:mutant phenotype:GO:0000372 Group I intron splicing [PMID:15618406]" /experiment="EXISTENCE:mutant phenotype:GO:0000373 Group II intron splicing [PMID:15618406]" /experiment="EXISTENCE:mutant phenotype:GO:0000963 mitochondrial RNA processing [PMID:15618406]" /experiment="EXISTENCE:mutant phenotype:GO:0005759 mitochondrial matrix [PMID:2535893]" /experiment="EXISTENCE:mutant phenotype:GO:0006392 transcription elongation by mitochondrial RNA polymerase [PMID:24732805]" /experiment="EXISTENCE:mutant phenotype:GO:0034337 RNA folding [PMID:21045551]" /note="Mitochondrial transcription elongation factor; DEAD-box protein; required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing; promotes RNA folding by stabilizing an early assembly intermediate; binds G-quadruplex (G4) nucleic acids and destabilizes G4RNA structures" /db_xref="GeneID:851775" /db_xref="SGD:S000002602" ORIGIN 1 mltsilikgr tpvlasrnll aalsncnhit wavsrrlynd gnrdqrnfgr nqrnnnsnry 61 rnsrfnsrpr trsredddev hfdkttfskl ihvpkednsk evtldsllee gvldkeihka 121 itrmefpglt pvqqktikpi lssedhdvia raktgtgktf aflipifqhl intkfdsqym 181 vkavivaptr dlalqieaev kkihdmnygl kkyacvslvg gtdfraamnk mnklrpnivi 241 atpgrlidvl ekysnkffrf vdykvldead rlleigfrdd letisgilne knsksadnik 301 tllfsatldd kvqklannim nkkeclfldt vdknepeahe ridqsvvise kfansifaav 361 ehikkqiker dsnykaiifa ptvkftsflc silknefkkd lpilefhgki tqnkrtslvk 421 rfkkdesgil vctdvgargm dfpnvhevlq igvpselany ihrigrtars gkegssvlfi 481 ckdelpfvre ledaknivia kqekyepsee iksevleavt eepedisdiv islissyrsc 541 ikeyrfserr ilpeiastyg vllndpqlki pvsrrfldkl glsrspigka mfeirdyssr 601 dgnnksydyd ddseisfrgn knynnrsqnr dyddepfrrs nnnrrsfsrs ndknnyssrn 661 sniy // LOCUS NP_878064 50 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR194W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878064 VERSION NP_878064.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184546.1 REFERENCE 1 (residues 1 to 50) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 50) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 50) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 50) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12037. Method: conceptual translation. FEATURES Location/Qualifiers source 1..50 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..50 /product="uncharacterized protein" /calculated_mol_wt="5998" CDS 1..50 /locus_tag="YDR194W-A" /coded_by="NM_001184546.1:1..153" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466435" /db_xref="SGD:S000028541" ORIGIN 1 mkqmmieasi skdtlrllic ffeikqchis lqptcyyqnw vryssiyyql // LOCUS NP_010481 533 aa linear PLN 30-JUN-2025 DEFINITION RNA-processing protein REF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010481 VERSION NP_010481.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180503.3 REFERENCE 1 (residues 1 to 533) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 533) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 533) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 533) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12038. On Jul 30, 2012 this sequence version replaced NP_010481.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..533 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..533 /product="RNA-processing protein REF2" /calculated_mol_wt="59688" CDS 1..533 /gene="REF2" /locus_tag="YDR195W" /coded_by="NM_001180503.3:1..1602" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:7862160]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:mutant phenotype:GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled [PMID:12819204]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:7862160]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:12773397]" /experiment="EXISTENCE:mutant phenotype:GO:1901901 regulation of protein localization to cell division site involved in cytokinesis [PMID:26771880]" /experiment="EXISTENCE:mutant phenotype:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:26771880]" /note="RNA-binding protein; involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes; putative regulatory subunit of type 1 protein phosphatase Glc7p, required for actomyosin ring formation, and for timely dephosphorylation and release of Bnr1p from the division site; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:851776" /db_xref="SGD:S000002603" ORIGIN 1 msapvpqlvn ishalqasti qqirldmvdf nkdcklssiq laridkyids lqaalnqftk 61 dnlhierkek nvteadiqly sglksmyldy lnqliklkhe kqhhstppia ndvsldffvn 121 qlpkfspeer knyidnliln knshnrlskm dglvdavinl cvldtsvaen vrsymklldt 181 lgfqkgsnst gtkanlkkkl asskakikds ekekekekdk skvkmktklk pspllnnddk 241 nsspsptast ssmkklksgl fnkneakste slptsskkkl sfskylnkdd admtklgtkr 301 sidvdfkvnp eastvasnii ssstsgsstt tvatpassee plkkktkisv qdsnvqsilr 361 ngkpkkaris sikflddsql ikvygddlpn qglqvsptql kkilkpfkeg epkeiilfed 421 msiklkpldl mflkntnsdd ymdisetkgg pihcetrtpl iyrknfnhfn pdlnkrppre 481 piefdlngnt nstptiakaf gknslllrkd rgglpykhvp ivkrnkyppr pvh // LOCUS NP_010482 241 aa linear PLN 30-JUN-2025 DEFINITION putative dephospho-CoA kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010482 VERSION NP_010482.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180504.3 REFERENCE 1 (residues 1 to 241) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 241) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 241) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 241) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12039. On Jul 30, 2012 this sequence version replaced NP_010482.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..241 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..241 /product="putative dephospho-CoA kinase" /EC_number="2.7.1.24" /calculated_mol_wt="27209" Region 2..188 /region_name="CoaE" /note="Dephospho-CoA kinase; pfam01121" /db_xref="CDD:426062" Site order(7,33,92,119..120,166) /site_type="other" /note="CoA-binding site [chemical binding]" /db_xref="CDD:238980" Site order(8..10,13..14,146,182) /site_type="other" /note="ATP-binding [chemical binding]" /db_xref="CDD:238980" CDS 1..241 /gene="CAB5" /locus_tag="YDR196C" /coded_by="NM_001180504.3:1..726" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0031315 extrinsic component of mitochondrial outer membrane [PMID:28357284]" /experiment="EXISTENCE:direct assay:GO:1990143 CoA-synthesizing protein complex [PMID:23789928]" /experiment="EXISTENCE:genetic interaction:GO:0015937 coenzyme A biosynthetic process [PMID:19266201]" /note="Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; involved in histone acylation; null mutant lethality is complemented by human homologs DCAKD and COASY and by E. coli coaE (encoding DPCK); extrinsic component of the mitochondrial outer membrane that also localizes to lipid droplets" /db_xref="GeneID:851777" /db_xref="SGD:S000002604" ORIGIN 1 mlvvgltggi acgkstvsrr lrdkyklpiv dadkiarqvv epgqnaydqi vlyfkdkipn 61 llledghlnr ealgkwvfsh kedlqalngi thpairyamf keigyyylkg yrmcvldvpl 121 lfegnldsic gvtvsvictq elqlerlmtr npelseedak nrlnsqmste ermarsdyil 181 qnnstlvdly eqiesvvkki qpsklrtvle yfppfgavsa ssivmsrllm kklqnkkssa 241 v // LOCUS NP_010483 389 aa linear PLN 30-JUN-2025 DEFINITION Cbs2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010483 VERSION NP_010483.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180505.1 REFERENCE 1 (residues 1 to 389) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 389) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 389) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 389) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12040. Method: conceptual translation. FEATURES Location/Qualifiers source 1..389 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..389 /product="Cbs2p" /calculated_mol_wt="44477" Region 247..376 /region_name="ApbA_C" /note="Ketopantoate reductase PanE/ApbA C terminal; pfam08546" /db_xref="CDD:462514" CDS 1..389 /gene="CBS2" /locus_tag="YDR197W" /gene_synonym="CBP7" /coded_by="NM_001180505.1:1..1170" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:3329045]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:3329045]" /experiment="EXISTENCE:physical interaction:GO:0005761 mitochondrial ribosome [PMID:15127226]" /note="Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader" /db_xref="GeneID:851778" /db_xref="SGD:S000002605" ORIGIN 1 msssiprvys lgnsamtyll alriaqlpsq pkvpsvvlll ndqkklnrfl nndskiivks 61 snnnketyhr qfmascvppi lsngeiapie nlivsdpssk fitaqlskyn kslrpetnil 121 flnpslnlle hlhryrwrfd earpnlfmgf ttpvdvgtih qefqlslkvk griqfhiaki 181 dgfprmsstg ksaslslrgd rqknekenna fyklfreisr lrsgigsdlv sfdlhvhgfq 241 dlfftelekl ilesctepll avydcvykke llkipgaqdi ikkliseqls iidrsypsln 301 tnpnysvifd kerifslvmr dlevnghkra klaqslnqln qtninelngf fvslgkykkc 361 nckwndillt likgkqfitk qkaldyhyl // LOCUS NP_010484 479 aa linear PLN 30-JUN-2025 DEFINITION protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010484 VERSION NP_010484.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180506.1 REFERENCE 1 (residues 1 to 479) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 479) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 479) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 479) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12041. Method: conceptual translation. FEATURES Location/Qualifiers source 1..479 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..479 /product="protein-lysine N-methyltransferase" /calculated_mol_wt="55819" Region 20..340 /region_name="SET_SETD4" /note="SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; cd19177" /db_xref="CDD:380954" Site order(33..34,246..247,271..276,324,336,338) /site_type="other" /note="putative SAM binding site" /db_xref="CDD:380954" Site order(33..34,52,244..249,271..275,285,322..325) /site_type="active" /note="putative active site [active]" /db_xref="CDD:380954" CDS 1..479 /gene="RKM2" /locus_tag="YDR198C" /coded_by="NM_001180506.1:1..1440" /experiment="EXISTENCE:direct assay:GO:0016279 protein-lysine N-methyltransferase activity [PMID:17005568]" /experiment="EXISTENCE:direct assay:GO:0018026 peptidyl-lysine monomethylation [PMID:17005568]" /experiment="EXISTENCE:mutant phenotype:GO:0018023 peptidyl-lysine trimethylation [PMID:17005568]" /note="Ribosomal protein lysine methyltransferase; responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp" /db_xref="GeneID:851779" /db_xref="SGD:S000002606" ORIGIN 1 megkvdvllt wlkksdkfyi apnisicesp etgrgivlsh gsirkndiiv svpsskqlnf 61 htilyhiskf nkelnipgit idrkpinyed niieaenkaw adpryglyse lskefllsls 121 sfqlvsfyil venfllpkwt hneiysdwkp ffdvwpsmee lrsipaiwnc dpnsryhsli 181 eylpaasrkh marisglvre dwetisevvl kwneiygsls ctknsdkfts delfslfvhv 241 yfiinsrcly akiplkieds psnftlvpyv dfmnhicesd lhcypqlspq lrsegeniig 301 igqftircgd hlydnineel flnygahsnd fllneygfvv dgnkwnyldi sdeiielidd 361 dkkevktfll ehdywgdyti netdisyrif valnyyvtrd errvrkfieg yisedyfkpk 421 issvlkellv sltakytktl seltekvsnl ennlclqnli tiykgyikil tqhlqdlqs // LOCUS NP_010486 604 aa linear PLN 30-JUN-2025 DEFINITION Vps64p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010486 VERSION NP_010486.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180508.3 REFERENCE 1 (residues 1 to 604) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 604) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 604) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 604) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12042. On Jul 30, 2012 this sequence version replaced NP_010486.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..604 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..604 /product="Vps64p" /calculated_mol_wt="67153" Region 159..291 /region_name="FHA_VPS64-like" /note="forkhead associated (FHA) domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 64 (VPS64) and similar proteins; cd22695" /db_xref="CDD:438747" Site order(188..189,224..225,227,246,248..249) /site_type="other" /note="putative phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438747" Region <406..>580 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" CDS 1..604 /gene="VPS64" /locus_tag="YDR200C" /gene_synonym="FAR9" /coded_by="NM_001180508.3:1..1815" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:23625923]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12514182]" /experiment="EXISTENCE:direct assay:GO:0005793 endoplasmic reticulum-Golgi intermediate compartment [PMID:22782902]" /experiment="EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]" /experiment="EXISTENCE:genetic interaction:GO:0031929 TOR signaling [PMID:23625923]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /note="Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance; VPS64 has a paralog, FAR10, that arose from the whole genome duplication" /db_xref="GeneID:851781" /db_xref="SGD:S000002608" ORIGIN 1 mvelekrrrp ppqlqhspyv rdqsnsqgmt ktpetsppkr pmgrarsnsr ssgsrsnvdi 61 dqytippgld llptasspps vhqvsqqqql spilankirs pfenqsqdqn dnsidptpag 121 qvtipveavs ppaldelskf qngstetlfr tgsprkkhth iiilkslnat fetkflvvpf 181 kpdglklgrp vtnsvnknns gskrdlfsqq vrpdngnfds rvlsrnhacl scdptsgkiy 241 irdlkssngt fvngvkirqn dvelkvgdtv dlgtdidskf ehrkisayve eisviplmnt 301 vsdptnlvmk kqdhtnknng nstningiki drghhnqhip irshlkenyt eagvtsatta 361 qraafeaamf gdinnseldd dilgpetevl sgifinnsag tsinlinmik tlttelslek 421 qeleklhsmq nfmqnytinl dfinkhmidm nekhllklst alqktlsenn dallkesedq 481 lkeikqqnnk vksacslkek qnheklqele selrelnlqi eeergknlvl tqsnfnggin 541 ndnnakvkqn dsreekkdte dtlisteelg vvegkrtrvs kgmlfgvvai sfglvatavk 601 qlpq // LOCUS NP_010487 165 aa linear PLN 30-JUN-2025 DEFINITION Spc19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010487 VERSION NP_010487.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180509.3 REFERENCE 1 (residues 1 to 165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 165) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12043. On Jul 30, 2012 this sequence version replaced NP_010487.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..165 /product="Spc19p" /calculated_mol_wt="18778" Region 6..129 /region_name="DASH_Spc19" /note="Spc19; pfam08287" /db_xref="CDD:429900" CDS 1..165 /gene="SPC19" /locus_tag="YDR201W" /coded_by="NM_001180509.3:1..498" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:16777964|PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15664196|PMID:15640796]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]" /experiment="EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479468|PMID:20479465]" /note="Essential subunit of Dam1 complex (aka DASH complex); complex couples kinetochores to force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body; SPC19 mRNA level is reduced when downstream gene RAV2 is deleted" /db_xref="GeneID:851782" /db_xref="SGD:S000002609" ORIGIN 1 mtdaleqsvl alegtvsvlk dsveslkcan epstnlastm lqtkrvfrlv peydverskl 61 dlieeveplv rtlgdklrks mgrmqreldt lqqtyelndl rlkknismdd ddalnspdmg 121 qeyegrdadd vvmmasstne eleelkklke kkkqlenkle ilkqk // LOCUS NP_010488 351 aa linear PLN 30-JUN-2025 DEFINITION Rav2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010488 VERSION NP_010488.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180510.1 REFERENCE 1 (residues 1 to 351) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 351) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 351) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 351) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12044. Method: conceptual translation. FEATURES Location/Qualifiers source 1..351 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..351 /product="Rav2p" /calculated_mol_wt="39886" Region 26..341 /region_name="Rogdi_lz" /note="Rogdi leucine zipper containing protein; pfam10259" /db_xref="CDD:463031" CDS 1..351 /gene="RAV2" /locus_tag="YDR202C" /coded_by="NM_001180510.1:1..1056" /experiment="EXISTENCE:genetic interaction:GO:0007035 vacuolar acidification [PMID:11844802|PMID:11283612]" /experiment="EXISTENCE:genetic interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:11283612|PMID:11844802]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:11844802|PMID:11283612]" /experiment="EXISTENCE:mutant phenotype:GO:0043254 regulation of protein-containing complex assembly [PMID:11844802]" /experiment="EXISTENCE:physical interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:11283612]" /experiment="EXISTENCE:physical interaction:GO:0043291 RAVE complex [PMID:11283612]" /note="Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme; shares extensive structural homology with ROGDI, a Rabconnectin-3 subunit that causes Kohlschutter-Tonz syndrome; human ROGDI can complement a yeast RAV2 null mutant" /db_xref="GeneID:851784" /db_xref="SGD:S000002610" ORIGIN 1 msvdlfpndr fgaedkydnf kdavkecswl ieeivkpqlp niidnfskcl emlesdqifk 61 mpvsngipne snkqndsptv kgvitrqgqy ivdfhivvrf pqfqrgkqvm frmntglnfl 121 liqfskimth lknileilnq lqvatdvsef vskfgvamel lnhslillqn pprdlvfped 181 nnfamkemfq dcysvcesta hilgleltlc rnelcielrn likvtkkpwc eidsktgrsf 241 cdqirnqvtn ernktlskil sengvqvqds tllnhiissf qseaitlpea qellrrgvtf 301 dnrvvmecek livstsdptl isisaklnsl kasmanhqan lvaskqlsty k // LOCUS NP_010490 335 aa linear PLN 30-JUN-2025 DEFINITION ubiquinone biosynthesis protein COQ4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010490 VERSION NP_010490.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180512.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12045. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..335 /product="ubiquinone biosynthesis protein COQ4" /calculated_mol_wt="38496" Region 94..305 /region_name="Coq4" /note="Coenzyme Q (ubiquinone) biosynthesis protein Coq4; pfam05019" /db_xref="CDD:461522" CDS 1..335 /gene="COQ4" /locus_tag="YDR204W" /coded_by="NM_001180512.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11469793]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:9266513|PMID:11469793]" /note="Protein with a role in ubiquinone (Coenzyme Q) biosynthesis; possibly functioning in stabilization of Coq7p; located on matrix face of mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex; human homolog COQ4 can complement yeast coq4 null mutant" /db_xref="GeneID:851785" /db_xref="SGD:S000002612" ORIGIN 1 mlrlsllrst atlpvkcqrr glilpaaamy tlgslifgke arladamerg elhnknvdya 61 keaeertelr iralantrpm eprynghvpl hryeklllfa isgwnsffhp edgynivqlg 121 eatalpvfle nlkqtmlsds sgrrilkeqp nitteilhmd klaklphntf gyvyyqwlkr 181 envspdtrap vkfiddpmha yifkryrqch dfyhaitnmp iiiegeitik aleganlgvp 241 mailggilap lrlkkvqrkr lyniylpwav rtglsckpli nvyweemlek dvtalrkelk 301 itlppdlrtm rkeraalrke idakynsqkr attpa // LOCUS NP_010491 724 aa linear PLN 30-JUN-2025 DEFINITION metal cation transporter MSC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010491 VERSION NP_010491.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180513.3 REFERENCE 1 (residues 1 to 724) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 724) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 724) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 724) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12046. On Jul 30, 2012 this sequence version replaced NP_010491.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..724 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..724 /product="metal cation transporter MSC2" /calculated_mol_wt="80447" Region 392..>561 /region_name="CzcD" /note="Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; COG1230" /db_xref="CDD:440843" CDS 1..724 /gene="MSC2" /locus_tag="YDR205W" /coded_by="NM_001180513.3:1..2175" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15277543|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005385 zinc ion transmembrane transporter activity [PMID:11058603]" /experiment="EXISTENCE:mutant phenotype:GO:0006829 zinc ion transport [PMID:15277543]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:11058603]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:15277543]" /note="Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids" /db_xref="GeneID:851786" /db_xref="SGD:S000002613" ORIGIN 1 mnlqellakv plllsyptii lssnlivpsh ndlisraast saaeyadekl iffstdhair 61 liflptfvas sfnlfahyfn finyssrrky yvlftaiyfl siltaifhpi qstcitllii 121 kllttadess pkialnfkti lktfvpfitl tlvilrwdps fdassgdvnk istslaayal 181 liltlryasp lilstlsssi gvvskdtsva qhsisrnkrf plilvlpifs fvllylmtiv 241 nktyniqllm vfvffgclsi fflslkdlft edgnqkkggq edeycrmfdi kymisylwlt 301 rftilltgim aivvhflsfn eitssiktdl lsllfvvvae yvssfsnkqp dshshnhahh 361 hshltdslpl enesmfkqma lnkdtrsifs flllntafmf vqllysfrsk slgllsdslh 421 maldctslll gliagvltkk pasdkfpfgl nylgtlagft ngvlllgivc gifveaieri 481 fnpihlhatn ellvvatlgl lvnlvglfaf dhgahdhggt dnenmkgifl hiladtlgsv 541 gvvistllik lthwpifdpi aslligslil lsalpllkst sanillrldd kkhnlvksal 601 nqisttpgit gyttprfwpt esgssghsha hthshaenhs hehhhdqkng sqehpslvgy 661 ihvqyvdgen stiikkrvek ifenvsikaw vqvepqnstc wcratsmnti sanpnslplq 721 pian // LOCUS NP_010492 884 aa linear PLN 30-JUN-2025 DEFINITION Ebs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010492 VERSION NP_010492.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180514.3 REFERENCE 1 (residues 1 to 884) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 884) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 884) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 884) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12047. On Jul 30, 2012 this sequence version replaced NP_010492.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..884 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..884 /product="Ebs1p" /calculated_mol_wt="99869" Region 79..214 /region_name="EST1" /note="Telomerase activating protein Est1; pfam10374" /db_xref="CDD:463062" Region 228..516 /region_name="EST1_DNA_bind" /note="Est1 DNA/RNA binding domain; pfam10373" /db_xref="CDD:431239" CDS 1..884 /gene="EBS1" /locus_tag="YDR206W" /coded_by="NM_001180514.3:1..2655" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:17984081]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16467471|PMID:17984081]" /experiment="EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:17984081]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0017148 negative regulation of translation [PMID:16467471]" /note="Protein involved in translation inhibition and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors; EBS1 has a paralog, EST1, that arose from the whole genome duplication" /db_xref="GeneID:851787" /db_xref="SGD:S000002614" ORIGIN 1 mepsntqked lptafngiks qlnsilksnq lfqdyallng flafvhskln aailtsiesq 61 cgksfaadld sfdqssissi ldfswesvhy pifkwfqmwr nyilfekenk kqqtkfidfr 121 kmnskmlkff ktvqnfyvnv intvykkydi svllpkriiq dlklsdient tnvgdilavk 181 tfnsssplah liptlfhrcl lflgtayryk tlleeisnky sisnfkksld ffrlaslvlp 241 sagetysqag aiflqtgnlg iavfnfvkgm mtkmpspvsi knfgalmvdn ksslnrslht 301 timntylqes kgprtpakei lefyflglfg svwsptswrd dtkpnqlnng iklrhlenal 361 yetmsaryln niktifhnli itiggfhlll krrsdvsakt lkdlrsneld ylnfafkyia 421 hilndivkes wsenpevsei lgmvriincw ikanpmvlqy sqsnlefvna laylindivk 481 kkpspsfsit ehipkrtywf eedlmvkgls fvnfqlsdfd dyekilemdh sldrlignpp 541 lcdklsasse mllrlqavvn issqllqnnn cgvewsdnks ryifnkkigf ketvknsmkt 601 skqsnekakl qrknkpsttn gsismadler qmrsssldsf sptmgysgss vpmapdtfnv 661 kpsgtitgnk vnvellkiel sgqnadgait nispgysnaa isssnstdes sfdlnnilss 721 mqqkhaeksf aksmqgvneq ipandvchqa qrpmqgglys sqqpssmssl nsayqnasmp 781 psasmvsypy pflnqqgqgv fppynaqnlq wqseayslks mnfanptwlg dqyqtsapss 841 ayaqaqrqmf qqpmqqdvgk ymqfpfdaqs ntdsmrgnsr nnmf // LOCUS NP_010493 836 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcriptional regulator UME6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010493 VERSION NP_010493.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180515.1 REFERENCE 1 (residues 1 to 836) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 836) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 836) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 836) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 836) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 836) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 836) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 836) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 836) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12048. Method: conceptual translation. FEATURES Location/Qualifiers source 1..836 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..836 /product="DNA-binding transcriptional regulator UME6" /calculated_mol_wt="90993" Region 765..801 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(766,770,775..778,780,783,793) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(771,774,781,788,791,798) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..836 /gene="UME6" /locus_tag="YDR207C" /gene_synonym="CAR80; NIM2; RIM16" /coded_by="NM_001180515.1:1..2511" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8528081|PMID:7926768]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:7926768|PMID:11081629]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16314178|PMID:16286007|PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363|PMID:19111667]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0140297 DNA-binding transcription factor binding [PMID:11081629]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:21123654|PMID:8614637|PMID:7926768|PMID:8618927|PMID :24881874]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:8618927|PMID:7926768]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:7926768]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:23478442]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:24881874]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:20876298]" /experiment="EXISTENCE:mutant phenotype:GO:0009847 spore germination [PMID:21059190]" /experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:18156287]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8614637|PMID:21123654|PMID:8618927]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:21123654|PMID:8618927]" /experiment="EXISTENCE:mutant phenotype:GO:1900089 negative regulation of inositol biosynthetic process [PMID:8614637]" /experiment="EXISTENCE:mutant phenotype:GO:1900470 positive regulation of phosphatidylserine biosynthetic process [PMID:8614637]" /experiment="EXISTENCE:mutant phenotype:GO:2001247 positive regulation of phosphatidylcholine biosynthetic process [PMID:8614637]" /experiment="EXISTENCE:physical interaction:GO:0140297 DNA-binding transcription factor binding [PMID:9150136]" /note="Rpd3L histone deacetylase complex subunit; key transcriptional regulator of early meiotic genes; involved in chromatin remodeling and transcriptional repression via DNA looping; binds URS1 upstream regulatory sequence, represses transcription by recruiting conserved histone deacetylase Rpd3p (through co-repressor Sin3p) and chromatin-remodeling factor Isw2p; couples metabolic responses to nutritional cues with initiation and progression of meiosis" /db_xref="GeneID:851788" /db_xref="SGD:S000002615" ORIGIN 1 mldkarsqsk hmdesnaaas llsmettann hhylhnktsr atlmnssqdg kkhaedevsd 61 gansrhptis sasieslktt ydenpllsim kstcapnntp vhtpsgspsl kvqsggdikd 121 dpkendtttt tnttlqdrrd sdnavhaaas plapsntpsd pkslcnghva qatdpqisga 181 iqpqytatne dvfpysstst nsntatttiv agakkkihlp ppqapavssp gttaagsgag 241 tgsgirsrtg sdlpliitsa nknngkttns pmsilsrnns tnnndnnsiq ssdsressnn 301 neiggylrgg tkrggspsnd sqvqhnvhdd qcavgvaprn fyfnkdreit dpnvkldene 361 skinisfwln skyrdeaysl nesssnnass ntdtptnsrh antsssitsr nnfqhfrfnq 421 ipsqpptsas sftstnnnnp qrnninrged pfatssrpst gffygdlpnr nnrnspfhtn 481 eqyipppppk yinskldglr srlllgpnsa ssstkldddl gtaaavlsnm rsspyrthdk 541 pisnvndmnn tnalgvpasr phsssfpskg vlrpillrih nseqqpifes nnstavfded 601 qdqnqdlspy hlnlnskkvl dptfesrtrq vtwnkngkri drrlsapeqq qqlevpplkk 661 srrsvgnarv asqtnsdyns lgesstssap sspslkassg laytadypna tspdfakskg 721 knvkpkaksk akqsskkrpn nttskskann sqesnnatss tsqgtrsrtg cwicrlrkkk 781 cteerphcfn cerlkldchy dafkpdfvsd pkkkqmklee ikkktkeakr ramkkk // LOCUS NP_010494 779 aa linear PLN 30-JUN-2025 DEFINITION 1-phosphatidylinositol-4-phosphate 5-kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010494 VERSION NP_010494.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180516.1 REFERENCE 1 (residues 1 to 779) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 779) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 779) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 779) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12049. Method: conceptual translation. FEATURES Location/Qualifiers source 1..779 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..779 /product="1-phosphatidylinositol-4-phosphate 5-kinase" /EC_number="2.7.1.68" /calculated_mol_wt="89190" Region 4..772 /region_name="MSS4" /note="Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]; COG5253" /db_xref="CDD:227578" CDS 1..779 /gene="MSS4" /locus_tag="YDR208W" /coded_by="NM_001180516.1:1..2340" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9624177]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22562153|PMID:9624177]" /experiment="EXISTENCE:direct assay:GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity [PMID:9624177|PMID:9624178]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:22562153]" /experiment="EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:9624177|PMID:9624178]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:22562153]" /experiment="EXISTENCE:genetic interaction:GO:0031321 ascospore-type prospore assembly [PMID:19502581]" /note="Phosphatidylinositol-4-phosphate 5-kinase; involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation" /db_xref="GeneID:851789" /db_xref="SGD:S000002616" ORIGIN 1 msvlrsqpps vvplhlttst srkteqepsl lhsaiierhq drsvpnsnsn pdsnhrikkd 61 rnnhtsyhss snsesnmesp rlsdgesstp tsieelnpti nnsrlvkrny sisidplhdn 121 snnntdddhp ntitsprpns tsnkemqkys fpegkeskki ttpslnsnnc ldldnsslvh 181 tdsyiqdlnd dhillnkrvs rrssrisavt atsttikqrr ntqdsnlpni pfhaskhsqi 241 lpmddsdvik langdtsmkp nsatkishsm tslplhplpq psqkskqyhm isksttslpp 301 endhyyqhsr gtnhnhaana aavnnntttt taatglkrse sataeikkmr qsllhkremk 361 rkrktflvdd drvlignkvs eghvnfiiay nmltgirvav srcsgimkpl tpadfrftkk 421 lafdyhgnel tpssqyafkf kdycpevfre lralfgldpa dylvsltsky ilselnspgk 481 sgsffyysrd ykyiiktihh sehihlrkhi qeyynhvrdn pntlicqfyg lhrvkmpisf 541 qnkikhrkiy flvmnnlfpp hldihitydl kgstwgrftn ldkerlakdr syrpvmkdln 601 wleegqkikf gplkkktflt qlkkdvella klntmdysll igihdinkak eddlqladta 661 sieeqpqtqg pirtgtgtvv rhffrefegg irasdqfnnd vdliyyvgii dfltnysvmk 721 kletfwrslr hdtklvsaip prdyanrfye fiedsvdplp qkktqssyrd dpnqknykd // LOCUS NP_001335758 137 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR209C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335758 VERSION NP_001335758.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348813.1 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80278. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..137 /product="uncharacterized protein" /calculated_mol_wt="15287" CDS 1..137 /locus_tag="YDR209C" /coded_by="NM_001348813.1:1..414" /note="hypothetical protein; conserved among S. cerevisiae strains; YDR209C is not an essential gene; partially overlaps uncharacterized gene YDR210W" /db_xref="GeneID:851791" /db_xref="SGD:S000002617" ORIGIN 1 mndgqflfqr ndpiilytfl lksnytvfrs iderlcdfvf yidhflnkri syripilirn 61 nntnilnncp ssfpplvdlv ghrlvaaedn pvavdlvdnn lvvvdlvdnn lavgvlvgsn 121 lvvgslvfal ltcfedg // LOCUS NP_010496 75 aa linear PLN 30-JUN-2025 DEFINITION cysteine-rich palmitoylated domain-containing protein CPP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010496 VERSION NP_010496.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180518.3 REFERENCE 1 (residues 1 to 75) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 75) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 75) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 75) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12050. On Jul 30, 2012 this sequence version replaced NP_010496.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..75 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..75 /product="cysteine-rich palmitoylated domain-containing protein CPP2" /calculated_mol_wt="8439" CDS 1..75 /gene="CPP2" /locus_tag="YDR210W" /coded_by="NM_001180518.3:1..228" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:38159851]" /note="Tail-anchored plasma membrane (PM) protein; C-terminal palmitoylation is required for membrane anchoring and protein stability; PM localization is polarized to the daughter cell; contains a conserved cysteine rich palmitoylated domain (CYSPD, aka CYSTM); related proteins in other organisms may be involved in response to stress" /db_xref="GeneID:851790" /db_xref="SGD:S000002618" ORIGIN 1 msqqqgyyqq gppqqgyyqq gppqqgyyqq gppqqgypqq qpvyvqqgqp keescldscl 61 kclcccflle lvcdn // LOCUS NP_058143 438 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058143 VERSION NP_058143.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184418.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12052. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..438 /product="gag protein" /calculated_mol_wt="49704" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..438 /locus_tag="YDR210W-A" /coded_by="NM_001184418.1:1..1317" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:851792" /db_xref="SGD:S000007392" ORIGIN 1 mesqqlhqnp hsqhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqeettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqdq hsevpqaktk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 ysdiltvlck svskmqtnnq elkdwialan leyngstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvns dhinestvss 421 qylsddnels lrpateri // LOCUS NP_058142 1770 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058142 VERSION NP_058142.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184419.4 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12051. On Jul 30, 2012 this sequence version replaced NP_058142.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1770 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="201965" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 574..641 /region_name="gag_pre-integrs" /note="GAG-pre-integrase domain; pfam13976" /db_xref="CDD:372857" Region 660..761 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1285..>1468 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1621..1757 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1625..1628,1662..1664,1667,1700,1727,1754) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1770 /locus_tag="YDR210W-B" /coded_by="join(NM_001184419.4:1..1293, NM_001184419.4:1295..5314)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:851793" /db_xref="SGD:S000007393" ORIGIN 1 mesqqlhqnp hsqhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqeettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqdq hsevpqaktk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 ysdiltvlck svskmqtnnq elkdwialan leyngstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvns dhinestvss 421 qylsddnels lgqqqkeskp trtidsndel pdhllidsga sqtlvrsahy lhhatpnsei 481 nivdaqkqdi pinaignlhf nfqngtktsi kalhtpniay dllslselan qnitacftrn 541 tlersdgtvl apivkhgdfy wlskkylips hiskltinnv nksksvnkyp yplihrmlgh 601 anfrsiqksl kknavtylke sdiewsnast yqcpdcligk stkhrhvkgs rlkyqesyep 661 fqylhtdifg pvhhlpksap syfisftdek trfqwvyplh drreesilnv ftsilafikn 721 qfnarvlviq mdrgseytnk tlhkfftnrg itacytttad srahgvaerl nrtllndcrt 781 llhcsglpnh lwfsavefst iirnslvspk ndksarqhag lagldittil pfgqpvivnn 841 hnpdskihpr gipgyalhps rnsygyiiyl pslkktvdtt nyvilqnnqt kldqfdydtl 901 tfdddlnrlt ahnqsfieqn eteqsydqnt esdhdyqsei einsdplvnd fssqslnplq 961 ldkepvqkvr apkevdadis eynilpstir srtphiinke stemggties dttsprhsst 1021 ftarnqkrpg spndmidlts qdrvnyglen ikttrlggte epyiqrnsdt nikyrttnst 1081 psiddrssns esttpiisie tkavcdntps idtdppeyrs sdhatpnimp dkssknvtad 1141 silddlplpd lthksptdts dvakdiphih srqtnsslgg mddsnvlttt kskkrsledn 1201 eteievsrdt wnnknmrsle pprskkrinl iaaikgvksi kpvrttlryd eaitynkdnk 1261 ekdryveayh keisqllkmn twdtnkyydr ndidpkkvin smfifnkkrd gthkarfvar 1321 gdiqhpdtyd sdmqsntvhh yalmtslsia ldndyyitql dissaylyad ikeelyirpp 1381 phlglndkll rlrkslyglk qsganwyeti ksylinccdm qevrgwscvf knsqvticlf 1441 vddmilfskd lnankkiitt lkkqydtkii nlgegdneiq ydilgleiky qrskymklgm 1501 ekslteklpk lnvplnpkgk klrapgqpgh yidqdeleid edeykekvhe mqkliglasy 1561 vgykfrfdll yyintlaqhi lfpsrqvldm tyeliqfmwd trdkqliwhk nkptkpdnkl 1621 vaisdasygn qpyyksqign ifllngkvig gkstkasltc tstteaeiha vseaipllnn 1681 lshlvqelnk kpiikglltd srstisiiks tneekfrnrf fgtkamrlrd evsgnnlyvy 1741 yietkkniad vmtkplpikt fklltnkwih // LOCUS NP_620387 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_620387 VERSION NP_620387.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184436.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12053. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198709" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region <907..1139 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" Region 1265..>1453 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YDR210C-D" /gene_synonym="YDR210W-D" /coded_by="join(NM_001184436.2:1..1305, NM_001184436.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:851794" /db_xref="SGD:S000007410" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnrsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsinsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp nsapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkdsrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsn dlniesdhdf qsdielypeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis diestdsggm 1021 hrldvpllap msqsnthess yaskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmntwdtd kyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydtgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmekslt eklpklnvpl 1501 npkgkklrap gqpghyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkptk pdnklvaisd asygnqpyyk 1621 sqigniflln gkviggkstk asltctstte aeihavseai pllnnlshlv qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_620388 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_620388 VERSION NP_620388.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184435.3 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12054. On Jul 30, 2012 this sequence version replaced NP_620388.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..440 /product="gag protein" /calculated_mol_wt="49056" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YDR210C-C" /gene_synonym="YDR210W-C" /coded_by="NM_001184435.3:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:851795" /db_xref="SGD:S000007409" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnrsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsinsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_010497 712 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF2B catalytic subunit epsilon [Saccharomyces cerevisiae S288C]. ACCESSION NP_010497 VERSION NP_010497.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180519.3 REFERENCE 1 (residues 1 to 712) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 712) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 712) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 712) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12055. On Jul 30, 2012 this sequence version replaced NP_010497.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..712 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..712 /product="translation initiation factor eIF2B catalytic subunit epsilon" /calculated_mol_wt="81030" Region 27..243 /region_name="eIF-2B_epsilon_N" /note="The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2; cd04197" /db_xref="CDD:133040" Region <256..408 /region_name="glgC" /note="glucose-1-phosphate adenylyltransferase; Provisional; PRK02862" /db_xref="CDD:179486" Region 344..422 /region_name="LbH_eIF2B_epsilon" /note="eIF-2B epsilon subunit, central Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is...; cd05787" /db_xref="CDD:100061" Region 550..704 /region_name="W2_eIF2B_epsilon" /note="C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; cd11558" /db_xref="CDD:211396" CDS 1..712 /gene="GCD6" /locus_tag="YDR211W" /coded_by="NM_001180519.3:1..2139" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9472020]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8336705|PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:8506384|PMID:9472020]" /experiment="EXISTENCE:genetic interaction:GO:0003743 translation initiation factor activity [PMID:8336705]" /experiment="EXISTENCE:genetic interaction:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8336705]" /experiment="EXISTENCE:genetic interaction:GO:0006446 regulation of translational initiation [PMID:8336705]" /experiment="EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10805739|PMID:12356745]" /experiment="EXISTENCE:mutant phenotype:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8441423]" /experiment="EXISTENCE:physical interaction:GO:0003743 translation initiation factor activity [PMID:8336705]" /experiment="EXISTENCE:physical interaction:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8336705|PMID:8506384]" /experiment="EXISTENCE:physical interaction:GO:0006446 regulation of translational initiation [PMID:8336705]" /experiment="EXISTENCE:physical interaction:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:9472020|PMID:8336705]" /note="Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; mutations in human ortholog cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:851797" /db_xref="SGD:S000002619" ORIGIN 1 magkkgqkks glgnhgknsd mdvedrlqav vltdsyetrf mpltavkprc llplanvpli 61 eytleflaka gvhevflics shanqindyi enskwnlpws pfkittimsp earctgdvmr 121 dldnrgiitg dfilvsgdvl tnidfskmle fhkkmhlqdk dhistmclsk astypktrti 181 epaafvldks tsrciyyqdl plpssrekts iqidpelldn vdefvirndl idcridicts 241 hvplifqenf dyqslrtdfv kgvissdilg khiyayltde yavrveswqt ydtisqdflg 301 rwcyplvlds niqddqtysy esrhiykekd vvlaqsckig kctaigsgtk igegtkiens 361 vigrncqige niriknsfiw ddciignnsi idhsliasna tlgsnvrlnd gciigfnvki 421 ddnmdldrnt kisasplkna gsrmydnesn eqfdqdlddq tlavsivgdk gvgyiyesev 481 sddedsstea ckeintlsnq ldelylsdds issatkktkk rrtmsvnsiy tdreeidsef 541 ededfekegi atveramenn hdldtallel ntlrmsmnvt yhevriatit allrrvyhfi 601 atqtlgpkda vvkvfnqwgl lfkrqafdee eyidlmniim ekiveqsfdk pdlilfsalv 661 slydndiiee dviykwwdnv stdprydevk kltvkwvewl qnadeessse ee // LOCUS NP_010498 559 aa linear PLN 30-JUN-2025 DEFINITION chaperonin-containing T-complex alpha subunit TCP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010498 VERSION NP_010498.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180520.1 REFERENCE 1 (residues 1 to 559) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 559) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 559) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 559) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12056. Method: conceptual translation. FEATURES Location/Qualifiers source 1..559 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..559 /product="chaperonin-containing T-complex alpha subunit TCP1" /calculated_mol_wt="60350" Region 17..549 /region_name="TCP1_alpha" /note="TCP-1 (CTT or eukaryotic type II) chaperonin family, alpha subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins...; cd03335" /db_xref="CDD:239451" Site order(17,21,49..52,54,72,74,78,82,85,392,540..546) /site_type="other" /note="ring oligomerisation interface [polypeptide binding]" /db_xref="CDD:239451" Site order(44..46,96,100,162,404,422,462,517,519) /site_type="other" /note="ATP/Mg binding site [chemical binding]" /db_xref="CDD:239451" Site order(442,460,469,471..472,475) /site_type="active" /note="stacking interactions [active]" /db_xref="CDD:239451" CDS 1..559 /gene="TCP1" /locus_tag="YDR212W" /gene_synonym="CCT1" /coded_by="NM_001180520.1:1..1680" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Alpha subunit of chaperonin-containing T-complex; complex mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein" /db_xref="GeneID:851798" /db_xref="SGD:S000002620" ORIGIN 1 msqlfnnsrs dtlflggeki sgddirnqnv latmavanvv ksslgpvgld kmlvddigdf 61 tvtndgatil slldvqhpag kilvelaqqq dreigdgtts vviiasellk ranelvknki 121 hpttiitgfr valreairfi nevlstsvdt lgketlinia ktsmsskiig adsdffsnmv 181 vdallavktq nskgeikypv kavnvlkahg ksatesllvp gyalnctvas qampkriagg 241 nvkiacldln lqkarmamgv qiniddpeql eqirkreagi vlervkkiid agaqvvlttk 301 giddlclkef veakimgvrr ckkedlrria ratgatlvss msnlegeetf essylglcde 361 vvqakfsdde cilikgtskh ssssiilrga ndysldemer slhdslsvvk rtlesgnvvp 421 gggcveaaln iyldnfattv gsreqlaiae faaalliipk tlavnaakds selvaklrsy 481 haasqmakpe dvkrrsyrny gldlirgkiv deihagvlep tiskvkslks aleacvailr 541 idtmitvdpe ppkedphdh // LOCUS NP_010499 913 aa linear PLN 30-JUN-2025 DEFINITION Upc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010499 VERSION NP_010499.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180521.1 REFERENCE 1 (residues 1 to 913) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 913) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 913) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 913) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 913) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 913) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 913) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 913) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 913) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12057. Method: conceptual translation. FEATURES Location/Qualifiers source 1..913 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..913 /product="Upc2p" /calculated_mol_wt="100209" Region 46..87 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(46,50,55..58,60,63,73) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(51,54,61,68,71,78) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 612..>753 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cl23766" /db_xref="CDD:419994" CDS 1..913 /gene="UPC2" /locus_tag="YDR213W" /gene_synonym="MOX4" /coded_by="NM_001180521.1:1..2742" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11533229]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11533229]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:18675371]" /experiment="EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:18675371]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:26448198]" /experiment="EXISTENCE:genetic interaction:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:26448198]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:16055745]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16055745|PMID:11533229|PMID:12077145|PMID:26448198|P MID:11238402]" /experiment="EXISTENCE:mutant phenotype:GO:0070452 positive regulation of ergosterol biosynthetic process [PMID:16055745|PMID:11533229]" /experiment="EXISTENCE:mutant phenotype:GO:0071456 cellular response to hypoxia [PMID:19807692]" /experiment="EXISTENCE:mutant phenotype:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:26448198]" /experiment="EXISTENCE:mutant phenotype:GO:2000911 positive regulation of sterol import [PMID:12077145]" /note="Sterol regulatory element binding protein; induces sterol biosynthetic genes, upon sterol depletion; acts as a sterol sensor, binding ergosterol in sterol rich conditions; relocates from intracellular membranes to perinuclear foci upon sterol depletion; redundant activator of filamentation with ECM22, up-regulating the expression of filamentous growth genes; contains a Zn[2]-Cys[6] binuclear cluster; UPC2 has a paralog, ECM22, that arose from the whole genome duplication" /db_xref="GeneID:851799" /db_xref="SGD:S000002621" ORIGIN 1 msevgiqnhk kavtkprrre kvielievdg kkvsttstgk rkfhnkskng cdnckrrrvk 61 cdegkpacrk ctnmklecqy tpihlrkgrg atvvkyvtrk adgsvesdss vdlpptikke 121 qtpfndiqsa vkasgssnds fpssasttks eseekssapi edknnmtpls mglqgtinkk 181 dmmnnffsqn gtigfgsper lnsgidglll pplpsgnmga fqlqqqqqvq qqsqpqtqaq 241 qasgtpnery gsfdlagspa lqstgmslsn slsgmllcnr ipsgqnytqq qlqyqlhqql 301 qlqqhqqvql qqyqqlrqeq hqqvqqqqqe qlqqyqqhfl qqqqqvllqq eqqpndeegg 361 vqeenskkvk egplqsqtse ttlnsdaatl qadalsqlsk mglslkslst fptagiggvs 421 ydfqellgik fpinngnsra tkasnaeeal anmqehhera aasvkendgq lsdtkspaps 481 nnaqggsasi mepqaadavs tmapismier nmnrnsnisp stpsavlndr qemqdsissl 541 gnltkaalen neptislqts qteneddasr qdmtskinne adrssvsagt sniaklldls 601 tkgnlnlidm klfhhyctkv wptitaakvs gpeiwrdyip elafdypflm hallafsath 661 lsrtetgleq yvsshrldal rllreavlei senntdalva salilimdsl anasgngtvg 721 nqslnsmsps awifhvkgaa tiltavwpls erskfhniis vdlsdlgdvi npdvgtitel 781 vcfdesiadl ypvgldspyl itlayldklh reknqgdfil rvftfpalld ktflallmtg 841 dlgamrimrs yykllrgfat evkdkvwfle gvtqvlpqdv deysggggmh mmldflgggl 901 psmtttnfsd fsl // LOCUS NP_010500 350 aa linear PLN 30-JUN-2025 DEFINITION Aha1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010500 VERSION NP_010500.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180522.3 REFERENCE 1 (residues 1 to 350) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 350) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 350) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 350) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12058. On Jul 30, 2012 this sequence version replaced NP_010500.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..350 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..350 /product="Aha1p" /calculated_mol_wt="39305" Region 13..150 /region_name="Aha1_N" /note="Activator of Hsp90 ATPase, N-terminal; pfam09229" /db_xref="CDD:462716" Region 215..346 /region_name="SRPBCC_Aha1" /note="Putative hydrophobic ligand-binding SRPBCC domain of the Hsp90 co-chaperone Aha1 and related proteins; cd08892" /db_xref="CDD:176901" Site order(216,218,220,229..231,233..234,239,253,261,263,265, 267,269..270,272,275,281,283..284,297..298,300,302,314,316, 318,320,324..332,335..337,340) /site_type="other" /note="putative hydrophobic ligand binding site [chemical binding]" /db_xref="CDD:176901" Site order(272,284,297,309..310) /site_type="other" /note="putative Hsp90 binding residues [polypeptide binding]" /db_xref="CDD:176901" CDS 1..350 /gene="AHA1" /locus_tag="YDR214W" /coded_by="NM_001180522.3:1..1053" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:12504007]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:36260391]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:36260391|PMID:39739753]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:12504007]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:12504007]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:36260391]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:36260391]" /experiment="EXISTENCE:physical interaction:GO:0005737 cytoplasm [PMID:12504007]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:12504007]" /note="Co-chaperone that binds Hsp82p and activates its ATPase activity; plays a role in determining prion variants; similar to Hch1p; involved in the nuclear import of Hsp82p after DNA damage; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851800" /db_xref="SGD:S000002622" ORIGIN 1 mvvnnpnnwh wvdkncigwa keyfkqklvg veagsvkdkk yakiksvssi egdcevnqrk 61 gkvislfdlk itvlieghvd skdgsalpfe gsinvpevaf dseassyqfd isifketsel 121 seakplirse llpklrqifq qfgkdllath gndiqvpesq vksnytrgnq kssfteikds 181 askpkknalp sststsapvs stnkvpqngs gnstsiylep tfnvpssely etfldkqril 241 awtrsaqffn sgpkletkek felfggnvis elvscekdkk lvfhwklkdw sapfnstiem 301 tfhesqefhe tklqvkwtgi pvgeedrvra nfeeyyvrsi kltfgfgavl // LOCUS NP_001335759 137 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR215C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335759 VERSION NP_001335759.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348814.1 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80279. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..137 /product="uncharacterized protein" /calculated_mol_wt="15050" CDS 1..137 /locus_tag="YDR215C" /coded_by="NM_001348814.1:1..414" /note="hypothetical protein; conserved across S. cerevisiae strains; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein" /db_xref="GeneID:851801" /db_xref="SGD:S000002623" ORIGIN 1 mktppnqekn nekisllfss qrltidvhps svyhivlssn nadrhqvtls ftarsrmmpl 61 trarpfgnhs smfrmfldam vilavasgvs lppqlpgrrs hnastpgakk pgkdhgamvs 121 efpangvitp vyfplrw // LOCUS NP_010502 1323 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcription factor ADR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010502 VERSION NP_010502.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180524.3 REFERENCE 1 (residues 1 to 1323) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1323) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1323) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1323) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12059. On Jul 30, 2012 this sequence version replaced NP_010502.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1323 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1323 /product="DNA-binding transcription factor ADR1" /calculated_mol_wt="150811" Region 104..126 /region_name="zf-C2H2" /note="Zinc finger, C2H2 type; pfam00096" /db_xref="CDD:395048" Region 106..126 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 118..143 /region_name="zf-H2C2_2" /note="Zinc-finger double domain; pfam13465" /db_xref="CDD:463886" Region 134..155 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..1323 /gene="ADR1" /locus_tag="YDR216W" /coded_by="NM_001180524.3:1..3972" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:1448103|PMID:9300483|PMID:10536147|PMID:1996109|PMID :1899286|PMID:12748191]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:10536147]" /experiment="EXISTENCE:direct assay:GO:0001093 TFIIB-class transcription factor binding [PMID:8943299]" /experiment="EXISTENCE:direct assay:GO:0001094 TFIID-class transcription factor complex binding [PMID:9742103]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10608811|PMID:27663510]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:10713069]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:1355328]" /experiment="EXISTENCE:mutant phenotype:GO:0032000 positive regulation of fatty acid beta-oxidation [PMID:1899286]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11431484|PMID:7760841|PMID:7500953|PMID:12748191|PMI D:1899286|PMID:1355328|PMID:8358828|PMID:10608811]" /experiment="EXISTENCE:mutant phenotype:GO:0071361 cellular response to ethanol [PMID:8358828|PMID:1355328]" /experiment="EXISTENCE:mutant phenotype:GO:1900064 positive regulation of peroxisome organization [PMID:7500953]" /experiment="EXISTENCE:mutant phenotype:GO:1900066 positive regulation of ethanol catabolic process [PMID:10608811|PMID:7760841]" /experiment="EXISTENCE:physical interaction:GO:0003713 transcription coactivator activity [PMID:8943299]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:8943299]" /note="Carbon source-responsive zinc-finger transcription factor; required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization" /db_xref="GeneID:851802" /db_xref="SGD:S000002624" ORIGIN 1 manvekpndc sgfpvvdlns cfsngfnnek qeiemetdds pillmsssas rensntfsvi 61 qrtpdgkiit tnnnmnskin kqldklpenl rlngrtpsgk lrsfvcevct rafarqehlk 121 rhyrshtnek pypcglcnrc ftrrdllirh aqkihsgnlg etishtkkvs rtitkarkns 181 assvkfqtpt ygtpdngnfl nrttantrrk aspeanvkrk ylkkltrras fsaqsassya 241 lpdqssleqh pkdrvkfstp elvpldlknp eldssfdlnm nldlnlnlds nfnialnrsd 301 ssgstmnldy klpesannyt yssgsptray vgantnskna sfndadllss sywikayndh 361 lfsvsesdet spmnselndt klivpdfkst ihhlkdsrss swtvaidnns nnnkvsdnqp 421 dfvdfqelld ndtlgndlle ttavlkefel lhddsvsata tsneidlshl nlsnspisph 481 kliyknkegt nddmlisfgl dhpsnreddl dklcnmtrdv qaifsqylkg eeskrsledf 541 lstsnrkekp dsgnytfygl dcltlskisr alpastvnnn qpshsieskl fnepmrnmci 601 kvlryyekfs hdssesvmds npnllskell mpavselney ldlfknnflp hfpiihpsll 661 dldldslqry tnedgyddae naqlfdrlsq gtdkeydyeh yqilsiskiv clplfmatfg 721 slhkfgyksq tielyemsrr ilhsfletkr rcrsttvnds yqniwlmqsl ilsfmfalva 781 dylekidssl mkrqlsalcs tirsnclpti sanseksinn nnepltfgsp lqyiifeski 841 rctlmaydfc qflkcffhik fdlsikekdv etiyipdnes kwasesiicn ghvvqkqnfy 901 dfrnfyysft yghlhsipef lgssmiyyey dlrkgtkshv fldridtkrl ersldtssyg 961 ndnmaatnkn iailiddtii lknnlmsmrf ikqidrsfte kvrkgqiaki ydsflnsvrl 1021 nflknysvev lceflvalnf sirnisslyv eeesdcsqrm nspelprihl nnqalsvfnl 1081 qgyyycfili ikflldfeat pnfkllrifi elrslansil lptlsrlypq efsgfpdvvf 1141 tqqfinkdng mlvpglsane hhngasaavk tklakkinve glamfineil vnsfndtsfl 1201 nmedpirnef sfdngdravt dlprsahfls dtgleginfs glndshqtvs tlnllrygen 1261 hsskhknggk gqgfaekyql slkyvtiakl fftnvkenyi hchmldkmas dfhtlenhlk 1321 gns // LOCUS NP_010503 1309 aa linear PLN 30-JUN-2025 DEFINITION chromatin-binding protein RAD9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010503 VERSION NP_010503.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180525.1 REFERENCE 1 (residues 1 to 1309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1309) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12060. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1309 /product="chromatin-binding protein RAD9" /calculated_mol_wt="148267" Region 772..900 /region_name="Rad9_Rad53_bind" /note="Fungal Rad9-like Rad53-binding; pfam08605" /db_xref="CDD:369994" Region 998..1113 /region_name="BRCT_p53bp1_rpt1" /note="first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins; cd17745" /db_xref="CDD:349376" Site order(1007..1008,1084..1088) /site_type="other" /note="gamma-H2A interaction site [polypeptide binding]" /db_xref="CDD:349376" Site order(1101,1103,1107,1110) /site_type="other" /note="p53 interaction site [polypeptide binding]" /db_xref="CDD:349376" CDS 1..1309 /gene="RAD9" /locus_tag="YDR217C" /coded_by="NM_001180525.1:1..3930" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:17721446]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:17726056]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:17721446]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:16219777|PMID:2664461]" /experiment="EXISTENCE:genetic interaction:GO:0051726 regulation of cell cycle [PMID:2664461]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:9564050]" /experiment="EXISTENCE:mutant phenotype:GO:0000785 chromatin [PMID:17721446]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:2664461]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:11267834]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:26490958]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:24302356]" /experiment="EXISTENCE:mutant phenotype:GO:0031571 mitotic G1 DNA damage checkpoint signaling [PMID:16166626|PMID:17721446]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:17721446|PMID:16166626]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8670896]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:2664461]" /experiment="EXISTENCE:mutant phenotype:GO:0110027 negative regulation of DNA strand resection involved in replication fork processing [PMID:25637499]" /note="DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M, plays a role in postreplication repair (PRR) pathway; transmits checkpoint signal by activating Rad53p and Chk1p; protects double-strand breaks from premature resection; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; Rad9p Chk1 Activating Domain (CAD) is phosphorylated at multiple sites by Cdc28p/Clb2p" /db_xref="GeneID:851803" /db_xref="SGD:S000002625" ORIGIN 1 msgqlvqwks spdrvtqsai kealhsplad gdmnemnvpv dplenkvnst niiegspkan 61 pnpvkfmnts eifqkslgll desprhddel nievgdndrp nanilhnert pdldrianff 121 ksnrtpgken lltkyqssdl edtplmlrkk mtfqtptdpl eqktfkklks dtgfcyygeq 181 ndgeenasle vteadatfvq maersadnyd calegivtpk rykdelsksg gmqdervqkt 241 qimisaespn sissydknki tgngrttrnv nkvfnnnedn igaieeknpv kkksenyssd 301 dlrernnqii qsneseeine leknlnvsgr endvnnldid insavsgtps rnnaeeemys 361 sesvnnreps kkwifryskd ktennsnrst qivnnprtqe mpldsisidt qplsksfnte 421 tnneletqii vsslsqgisa qkgpvfhstg qteeiktqii nspeqnalna tfetpvtlsr 481 infepilevp etsspskntm skpsnsspip kekdtfnihe revetnnvfs ndiqnssnaa 541 trddiiiags sdfneqkeit driylqlsgk qisdsgsdet ermspneldt kkestimsev 601 eltqelpeve eqqdlqtspk klvveeetlm eikkskgnsl qlhddnkecn sdkqdgtesl 661 dvaliehesk gqsselqknl mqlfpsesqe iiqnrrtikr rqkdtieige eeenrstkts 721 ptkhlkrnsd ldaasikrep scsitiqtge tgsgkdskeq syvfpegirt adnsflskdd 781 iifgnavwcq ytwnykfypg illevdtnqd gcwiyfetgr sltkdediyy ldirigdavt 841 fdgneyvvvg lecrshdlni ircirgydtv hlkkknasgl lgkrtlikal ssisldlsew 901 akrakiiled neknkgdayr ylrhpirgrk smtnvlspkk htddekdint htevynneie 961 sssekkeivk kdsrdalaeh agapsllfss geirtgnvfd kcifvltslf enreelrqti 1021 esqggtvies gfstlfnfth plakslvnkg ntdnirelal klawkphslf adcrfaclit 1081 krhlrslkyl etlalgwptl hwkfisacie kkrivphliy qyllpsgesf rlsldspskg 1141 giiksnnifs fytqflrgsn lrdqicgvkk mlndyivivw grseldsfvk fafaclsagr 1201 mltidlpnid vddtepllna ldslvprigs elsnrklkfl iyanenngks qmkllerlrs 1261 qislkfkkfn yifhteskew liqtiinedt gfhdditdnd iyntisevr // LOCUS NP_010504 423 aa linear PLN 30-JUN-2025 DEFINITION septin SPR28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010504 VERSION NP_010504.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180526.1 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12061. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..423 /product="septin SPR28" /calculated_mol_wt="48062" Region 16..423 /region_name="CDC3" /note="Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5019" /db_xref="CDD:227352" CDS 1..423 /gene="SPR28" /locus_tag="YDR218C" /coded_by="NM_001180526.1:1..1272" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:8885406]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18826657]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:18826657]" /experiment="EXISTENCE:direct assay:GO:0031105 septin complex [PMID:18826657|PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0072687 meiotic spindle [PMID:18826657]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:18826657]" /note="Sporulation-specific homolog of the CDC3/10/11/12 family of genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes" /db_xref="GeneID:851804" /db_xref="SGD:S000002626" ORIGIN 1 mfpmkdhsal eqhtlsrdel rrrkgykkgl qlsilllgek gsgkstflnn lcgqdislsd 61 gdydddddkv tnnvtpengn aiedidpgyk tahlspglkl vtrrvylnde lgvpitldii 121 lfpgcgdnvd nsqssvvikn yldqqfanvl keevrikrnt ketdgrphvc lyflkstprg 181 vkkfdielmk ticdkvnlip iipkadglte telnlhkdiv rqeisqnnir vfdfksdtlg 241 etlalydmdi dsssakskyd ndtkikeisp faivcsktfn knsenrvehi rtyewgslvv 301 edqntsdfiy lkaillgshl qelkdvtnnv lyenyrakvl tekknnydip nysyidetsr 361 gsvsnvstrr nsasrtlgnp dtndenayqi hkeideknri iedyqrkidl lekmlaaphq 421 nkv // LOCUS NP_010505 465 aa linear PLN 30-JUN-2025 DEFINITION Mfb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010505 VERSION NP_010505.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180527.3 REFERENCE 1 (residues 1 to 465) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 465) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 465) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 465) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12062. On Jul 30, 2012 this sequence version replaced NP_010505.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..465 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..465 /product="Mfb1p" /calculated_mol_wt="53037" Region 17..58 /region_name="F-box_ScMFB1-like" /note="F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and similar proteins; cd22146" /db_xref="CDD:438917" Site order(20,24,27..28,31..32,36,38..39,43..45,47) /site_type="other" /note="putative Skp1 binding site [polypeptide binding]" /db_xref="CDD:438917" CDS 1..465 /gene="MFB1" /locus_tag="YDR219C" /coded_by="NM_001180527.3:1..1398" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:26839174]" /experiment="EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:26839174]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:35281729|PMID:26839174]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:16790494]" /experiment="EXISTENCE:mutant phenotype:GO:0048312 intracellular distribution of mitochondria [PMID:35281729|PMID:26839174]" /note="Mitochondria-associated F-box protein; tether that anchors higher-functioning mitochondria at the mother cell distal tip throughout the cell cycle and at the bud tip prior to cytokinesis; role in maintenance of normal mitochondrial morphology and quality control; interacts with Skp1p through the F-box motif; asymmetrically localized to the mother cell through the cell cycle with some bud tip localization just before cytokinesis; function regulated by the bud site selection machinery" /db_xref="GeneID:851805" /db_xref="SGD:S000002627" ORIGIN 1 mtlfscsvqm pleersltnl plnllfrils hldmndlqni gktctllrml anenivyrna 61 vigsngnmww tknvlvdvfd vlnfnrkamk tlnshnislv aslrnvqrky klgvidpark 121 tisyrtneve skekgsvkdl nmdlneptei treqiahtai lqgmnqfiel ndkafrthsa 181 dsddtyieen ngeihslhgl eknttfeedl vkkppfipsp tfsnysrsst nsvfsssspk 241 lldddwnnit mdftksrdpd ykemtptste ssdsitrlrk snkvkdkael feklifrdsr 301 plktkkkdnp rlklssslsa ndedfrkiis ppsdilpkvg rrsvsrgyle eierhypdfn 361 gettnplaik rvnstkiany eqliikenss nckgiteknd enkfqrshts pvielskphq 421 rsklkavvtd gnkicyrkie ldnpsgsntn dhvikrldan tdfni // LOCUS NP_010507 702 aa linear PLN 30-JUN-2025 DEFINITION Gtb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010507 VERSION NP_010507.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180529.3 REFERENCE 1 (residues 1 to 702) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 702) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 702) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 702) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12063. On Jul 30, 2012 this sequence version replaced NP_010507.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..702 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..702 /product="Gtb1p" /calculated_mol_wt="79777" Region 28..187 /region_name="PRKCSH-like" /note="Glucosidase II beta subunit-like; pfam12999" /db_xref="CDD:372423" Region 168..>315 /region_name="CwlO1" /note="Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown]; COG3883" /db_xref="CDD:443091" Region <635..695 /region_name="PRKCSH" /note="Glucosidase II beta subunit-like protein; cl06793" /db_xref="CDD:414904" CDS 1..702 /gene="GTB1" /locus_tag="YDR221W" /coded_by="NM_001180529.3:1..2109" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:16373354]" /experiment="EXISTENCE:mutant phenotype:GO:0000271 polysaccharide biosynthetic process [PMID:16373354]" /experiment="EXISTENCE:mutant phenotype:GO:0004558 alpha-1,4-glucosidase activity [PMID:16373354|PMID:19542522]" /experiment="EXISTENCE:mutant phenotype:GO:0006491 N-glycan processing [PMID:16373354]" /experiment="EXISTENCE:physical interaction:GO:0017177 glucosidase II complex [PMID:16373354]" /note="Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p; involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER; relocalizes from ER to cytoplasm upon DNA replication stress" /db_xref="GeneID:851807" /db_xref="SGD:S000002629" ORIGIN 1 mvsmfslfll lieqsplvas lqqsqrhivg vpwekqhlyd snepdltkwh clnhedivld 61 isqindgvcd cpdgsdepgs aacvedifks vaegggkvnk yfycdnkgfi pryirkseva 121 dgicdccdcs dellsgyelf dagsncsqlk nefdimaske lssyregkea leelerkygt 181 keeaitrgnc leedkekasa eikvlsnrls enrakleqlr geyfnqlshd pilyqfeqln 241 strlgsdilt sftmvsrvsk gyqdifkils dlseaytpsl ndkvvndnik kfrkvrrrae 301 kakinadski ddeqadnlyl yfteevpqif lkresentlr yvigksnfvq alvegkinyt 361 ndileyiref rlimddisqn ynvnfqdagv ksavdsykny lgeygelael epahpsesll 421 rslsevtsfv nenapkvlpp daveseqdtn sdhigtsgdl rnklkeilsk lnifssrkdl 481 vslekrfrsc esqvsllene lkqkmdykkl ldetedegtn stagnltell elmgsqsycl 541 ddildnyvyt icfqrpmteg viyqaedkvd gkkvligrfk tsgfnvdlnm ekyaehlkat 601 ydeksdlisn laaiqdddgn mqhyvfgnln elnnglvley engdqcwngp rrsatvfvrc 661 sdkfkirsvh eatkcnyifd vvgplgcnkt feyeppkfnl se // LOCUS NP_010508 415 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR222W [Saccharomyces cerevisiae S288C]. ACCESSION NP_010508 VERSION NP_010508.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180530.1 REFERENCE 1 (residues 1 to 415) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 415) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 415) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 415) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12064. Method: conceptual translation. FEATURES Location/Qualifiers source 1..415 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..415 /product="uncharacterized protein" /calculated_mol_wt="47283" Region 76..267 /region_name="Svf1" /note="Svf1-like N-terminal lipocalin domain; pfam08622" /db_xref="CDD:430110" Region 269..415 /region_name="Svf1_C" /note="Svf1-like C-terminal lipocalin-like domain; pfam17187" /db_xref="CDD:465375" CDS 1..415 /locus_tag="YDR222W" /coded_by="NM_001180530.1:1..1248" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YDR222W has a paralog, YLR225C, that arose from the whole genome duplication" /db_xref="GeneID:851808" /db_xref="SGD:S000002630" ORIGIN 1 mlesssdkik fapikevdyk kpvsksknyt lindiqplew ychndsetgy qhtisnktdg 61 grglfrvmkk smetrvetqt lyftdlhtgl cgfvqllyst vmggiykgfq lnfkvfgses 121 nntdydvwes fklddiaefq plkfvsrnvi feflsnknek lgsigqlsik cdlptcnnti 181 qnlkidllvd lfqgfkmnpn gcnyyfdkqi smsdefvssd kmirhvfvpr gkcngnisyd 241 kklnsgdfqn knisltdvpv vyldavqgll pnkaaskwnf lcfqsenysv laiefttprd 301 hdnvtvtvws iteknklisi gssvqspkrh vrfratstdk esgwvyptsi kfpggfsehd 361 lrlvnrydvl gelpsmvrsl aqkivsikpf iyqycqpsky khekgisive stfis // LOCUS NP_010509 467 aa linear PLN 30-JUN-2025 DEFINITION Crf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010509 VERSION NP_010509.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180531.1 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12065. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..467 /product="Crf1p" /calculated_mol_wt="51566" Region 345..>409 /region_name="CRF1" /note="Transcription factor CRF1; pfam10380" /db_xref="CDD:371017" CDS 1..467 /gene="CRF1" /locus_tag="YDR223W" /coded_by="NM_001180531.1:1..1404" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:15620355]" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:15620355]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15620355]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15620355]" /experiment="EXISTENCE:mutant phenotype:GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15620355]" /experiment="EXISTENCE:physical interaction:GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15620355]" /note="Transcriptional corepressor; involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain; CRF1 has a paralog, IFH1, that arose from the whole genome duplication" /db_xref="GeneID:851809" /db_xref="SGD:S000002631" ORIGIN 1 mllsapvnst vrrkphspnk kkpketgtaa sfssssstvv lssnndgsfd alwdpsiska 61 sdfessyisa krlkpessnr qkkknsykys reentnevee ktslgssskt eadnifndql 121 tsagnttyvs nkrdvnfgan savvllglpt skseshrqyh spsasttned eedigvdilv 181 dnhidscetv sinnnrgith qypetesdvd fdeaviltpm dgtdkgvknp rplekkysss 241 cfedrtplnl ddghfsecnh fstldvssff hlnehvhkid eveldgpdrt fsldnvaint 301 rkkdidclyn ssredlsnlt cssegprnds ydsdynidev tyrddestde deslptpdrk 361 rkkighkace ildskrigik vpklyvwsls dkpfsvidgl ctkslyplsd dintpeslss 421 csssvssren qkgdatfdnd amiadllnig glevekasng hielige // LOCUS NP_010510 131 aa linear PLN 30-JUN-2025 DEFINITION histone H2B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010510 VERSION NP_010510.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180532.3 REFERENCE 1 (residues 1 to 131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 131) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12066. On Jul 30, 2012 this sequence version replaced NP_010510.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..131 /product="histone H2B" /calculated_mol_wt="14121" Region <3..38 /region_name="COG1754" /note="Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]" /db_xref="CDD:441360" Region 33..126 /region_name="HFD_H2B" /note="histone-fold domain found in histone H2B and similar proteins; cd22910" /db_xref="CDD:467035" Site order(34,36,39,41,43..45,47..49,52..59,61..62,65..66, 69..70,72..74,76..78,82,92..93,95,98..99,102,105..107,110, 113..115,117..118,121..122,125..126) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467035" Site order(34..40,43..44,46,57..59,92) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:467035" Site order(38,42..44,46..47,50..52,57..59,63,99,103,112..113, 115..116,119..120,122..123,126) /site_type="other" /note="Hif1 binding site [polypeptide binding]" /db_xref="CDD:467035" Site order(65,68..69,71..72,75,80,83,86..88,96..97,100,104..105) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467035" CDS 1..131 /gene="HTB1" /locus_tag="YDR224C" /gene_synonym="SPT12" /coded_by="NM_001180532.3:1..396" /experiment="EXISTENCE:direct assay:GO:0000786 nucleosome [PMID:9256430]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:8017102]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9256430|PMID:8017102]" /experiment="EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:11973294]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17526727]" /note="Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation" /db_xref="GeneID:851810" /db_xref="SGD:S000002632" ORIGIN 1 msakaekkpa skapaekkpa akktststdg kkrskarket yssyiykvlk qthpdtgisq 61 ksmsilnsfv ndiferiate asklaaynkk stisareiqt avrlilpgel akhavsegtr 121 avtkyssstq a // LOCUS NP_010511 132 aa linear PLN 30-JUN-2025 DEFINITION histone H2A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010511 VERSION NP_010511.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180533.3 REFERENCE 1 (residues 1 to 132) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 132) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 132) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 132) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12067. On Jul 30, 2012 this sequence version replaced NP_010511.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..132 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..132 /product="histone H2A" /calculated_mol_wt="13858" Region 18..131 /region_name="PTZ00017" /note="histone H2A; Provisional" /db_xref="CDD:185399" CDS 1..132 /gene="HTA1" /locus_tag="YDR225W" /gene_synonym="H2A1; SPT11" /coded_by="NM_001180533.3:1..399" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17526727]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15781691]" /note="Histone H2A; core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p; N-terminally propionylated in vivo" /db_xref="GeneID:851811" /db_xref="SGD:S000002633" ORIGIN 1 msggkggkag saakasqsrs akagltfpvg rvhrllrrgn yaqrigsgap vyltavleyl 61 aaeilelagn aardnkktri iprhlqlair nddelnkllg nvtiaqggvl pnihqnllpk 121 ksakatkasq el // LOCUS NP_010512 222 aa linear PLN 30-JUN-2025 DEFINITION adenylate kinase ADK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010512 VERSION NP_010512.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180534.1 REFERENCE 1 (residues 1 to 222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 222) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12068. Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..222 /product="adenylate kinase ADK1" /EC_number="2.7.4.3" /calculated_mol_wt="24124" Region 8..219 /region_name="Adk" /note="Adenylate kinase or related kinase [Nucleotide transport and metabolism]; COG0563" /db_xref="CDD:440329" CDS 1..222 /gene="ADK1" /locus_tag="YDR226W" /gene_synonym="AKY1; AKY2" /coded_by="NM_001180534.1:1..669" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:20659900]" /experiment="EXISTENCE:direct assay:GO:0004017 AMP kinase activity [PMID:18433446|PMID:15753074]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:2850178]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:2850178]" /experiment="EXISTENCE:direct assay:GO:0006172 ADP biosynthetic process [PMID:2848829]" /experiment="EXISTENCE:mutant phenotype:GO:0004017 AMP kinase activity [PMID:18433446|PMID:2850178]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:20980819]" /experiment="EXISTENCE:mutant phenotype:GO:0009117 nucleotide metabolic process [PMID:2850178]" /experiment="EXISTENCE:mutant phenotype:GO:0036388 pre-replicative complex assembly [PMID:20659900]" /note="Adenylate kinase, required for purine metabolism; controls ATP homeostasis; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress; mutations affecting Adk1p catalytic activity deregulate expression of phosphate utilization genes PHO5 and PHO84; human homolog AK1 can complement yeast adk1 mutant" /db_xref="GeneID:851812" /db_xref="SGD:S000002634" ORIGIN 1 msssesirmv ligppgagkg tqapnlqerf haahlatgdm lrsqiakgtq lgleakkimd 61 qgglvsddim vnmikdeltn npackngfil dgfprtipqa ekldqmlkeq gtplekaiel 121 kvddellvar itgrlihpas grsyhkifnp pkedmkddvt gealvqrsdd nadalkkrla 181 ayhaqtepiv dfykktgiwa gvdasqppat vwadilnklg kd // LOCUS NP_010513 1358 aa linear PLN 30-JUN-2025 DEFINITION chromatin-silencing protein SIR4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010513 VERSION NP_010513.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180535.1 REFERENCE 1 (residues 1 to 1358) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1358) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1358) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1358) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12069. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1358 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1358 /product="chromatin-silencing protein SIR4" /calculated_mol_wt="151931" Region <2..>106 /region_name="PTZ00449" /note="104 kDa microneme/rhoptry antigen; Provisional" /db_xref="CDD:185628" Region 801..893 /region_name="Sir4p-SID_like" /note="The SID domain of Saccharomyces cerevisiae silent information regulator 4, a Sir2p interaction domain; and related domains; cd13746" /db_xref="CDD:259839" Site order(810,813..814,817..818,821,824..825,827..829,832..833, 835..837,839..841,843,845..847,850,852..856,858..861, 864..865,867,869..870,872..873,877,880..884,886..891,893) /site_type="other" /note="Sir2p interface [polypeptide binding]" /db_xref="CDD:259839" Region 1272..1350 /region_name="Sir4_CC_C" /note="C-terminal coiled coil domain found in Saccharomyces cerevisiae silent information regulator 4 (Sir4p) and similar proteins; cd22863" /db_xref="CDD:439379" Site order(1274,1277..1278,1281,1284,1288..1289,1295,1298..1299, 1302..1303,1305..1306,1309,1312..1313,1316..1317, 1319..1320,1323..1324,1326..1327,1330,1333..1334, 1337..1338,1344) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:439379" CDS 1..1358 /gene="SIR4" /locus_tag="YDR227W" /gene_synonym="ASD1; STE9; UTH2" /coded_by="NM_001180535.1:1..4077" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:9710643]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:19217406|PMID:22654676]" /experiment="EXISTENCE:direct assay:GO:0005677 chromatin silencing complex [PMID:9122169]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:19217406]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:22654676]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:27122604]" /experiment="EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:22654676]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:3297920|PMID:26587833|PMID:22654676]" /experiment="EXISTENCE:mutant phenotype:GO:0031453 positive regulation of heterochromatin formation [PMID:26587833]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:1913809|PMID:26587833|PMID:9501103|PMID:22654676]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:27122604|PMID:26399229]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:12080091]" /experiment="EXISTENCE:mutant phenotype:GO:0097695 establishment of protein-containing complex localization to telomere [PMID:29290466]" /note="SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; some SIR4 alleles prolong lifespan; required for Ku-mediated telomerase recruitment, telomere lengthening, and telomere hypercluster formation in quiescent yeast cells" /db_xref="GeneID:851813" /db_xref="SGD:S000002635" ORIGIN 1 mpndnktpnr sstpkftkkp vtpndkiper eeksnevktp kiplftfaks knysrpstai 61 htsphqpsdv kptshkqlqq pkssplkknn ynsfphsnle kisnskllsl lrsktsagri 121 esnnpshdas rslasfeqta fsrhaqqqts tfnskpvrti vpistsqtnn sflsgvksll 181 seekirdysk eilginlane qpvlekplkk gsadigasvi sltkdksirk dtveekkeek 241 lnigknfahs dslsvpkvsa gdsgispees karspgiakp naiqtevygi neestnerle 301 inqekpvkld ensanstvas aldtngtsat tetltskkiv pspkkvaidq dkitlhdekt 361 lapskhqpit seqkmkedad lkrmeilksp hlskspadrp qgrrnsrnfs trdeettkla 421 flveyegqen nynstsrste kkndmntsak nkngenkkig krppeimste ahvnkvteet 481 tkqiqsvrid grkvlqkvqg eshidsrnnt lnvtpskrpq lgeipnpmkk hkpnegrtpn 541 isngtiniqk klepkeivrd ilhtkessne akktiqnpln ksqntalpst hkvtqkkdik 601 igtndlfqve sapkisseid renvkskdep vskavesksl lnlfsnvlka pfikseskpf 661 ssdalskeka nfletiaste kpenktdkvs lsqpvsaskh eysdnfpvsl sqpskksfan 721 htedeqiekk kicrgrmnti ithpgkmelv yvsdsddsss dndsltdles lssgesneik 781 vtndldtsae kdqiqagkwf dpvldwrksd reltknilwr iadkttydke titdlieqgi 841 pkhsylsgnp ltsvtndics venyetssaf fyqqvhkkdr lqylplyavs tfentnntek 901 ndvtnknini gkhsqeqnss sakpsqiptv ssplgfeetk lsttptksnr rvshsdtnss 961 kpkntkenls ksswrqewla nlklisvslv defpselsds drqiinekmq llkdifannl 1021 ksaisnnfre sdiiilkgei edypmsseik iyynelqnkp dakkarfwsf mktqrfvsnm 1081 gfdiqkscep vsistsvkph vvepehmada kimpkdilqi tkkplmvknv kpssppdvks 1141 lvqlstmetk tlpekkqfds ifnsnkakii pgngkhasen islsfsrpas ygyfsvgkrv 1201 pivedrrvkq ldditdsntt eiltsvdvlg thsqtgtqqs nmytstqkte leidnkdsvt 1261 ecskdmkedg lsfvdivlsk aasaldekek qlavaneiir slsdevmrne iritslqgdl 1321 tftkkclena rsqisekdak inklmekdfq vnkeikpy // LOCUS NP_010514 626 aa linear PLN 30-JUN-2025 DEFINITION Pcf11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010514 VERSION NP_010514.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180536.3 REFERENCE 1 (residues 1 to 626) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 626) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 626) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 626) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 626) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 626) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 626) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 626) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 626) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12070. On Jul 30, 2012 this sequence version replaced NP_010514.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..626 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..626 /product="Pcf11p" /calculated_mol_wt="71767" Region 9..135 /region_name="CID_Pcf11" /note="CID (CTD-Interacting Domain) of Pcf11; cd16982" /db_xref="CDD:340779" Site order(24..25,27,65,68..69,72..73,104,108,111) /site_type="other" /note="CTD binding site [polypeptide binding]" /db_xref="CDD:340779" Region 421..>446 /region_name="zf_UBZ" /note="Ubiquitin-Binding Zinc Finger; pfam18439" /db_xref="CDD:465769" Region 467..562 /region_name="CFIA_Pcf11" /note="Subunit of cleavage factor IA Pcf11; pfam11526" /db_xref="CDD:431919" CDS 1..626 /gene="PCF11" /locus_tag="YDR228C" /coded_by="NM_001180536.3:1..1881" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:12727883]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:15998810]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006369 termination of RNA polymerase II transcription [PMID:12727883|PMID:15998810]" /experiment="EXISTENCE:mutant phenotype:GO:0000993 RNA polymerase II complex binding [PMID:15998810]" /experiment="EXISTENCE:mutant phenotype:GO:0003729 mRNA binding [PMID:15998810]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:15998810]" /experiment="EXISTENCE:mutant phenotype:GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled [PMID:12819204]" /experiment="EXISTENCE:mutant phenotype:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:12819204]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:15998810]" /experiment="EXISTENCE:physical interaction:GO:0005849 mRNA cleavage factor complex [PMID:11344258]" /note="mRNA 3' end processing factor; essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); required for gene looping; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:851814" /db_xref="SGD:S000002636" ORIGIN 1 mdhdtevivk dfnsileelt fnsrpiittl tklaeenisc aqyfvdaies riekcmpkqk 61 lyafyaldsi cknvgspyti yfsrnlfnly krtyllvdnt trtklinmfk lwlnpndtgl 121 plfegsalek ieqflikasa lhqknlqaml ptptvplllr didkltclts erlknqpnde 181 klkmkllvls qlkqelkrek ltlnalkqvq mqlrqvfsqd qqvlqermry helqqqqqqq 241 qqqqqqqqqq qqqyhetkdm vgsytqnsns aiplfgnnsd ttnqqnslss slfgnisgve 301 sfqeiekkks lnkinnlyas lkaegliytp pkesivtlyk klnghsnysl dshekqlmkn 361 lpkipllndi lsdckayfat vnidvlnnps lqlseqtllq enpivqnnli hllyrskpnk 421 csvcgkrfgn sesekllqne hldwhfrint rikgsqntan tgisnsnlnt tttrkniqsr 481 nwylsdsqwa afkddeitst khkndytdph anknidksal nihadendeg svdntlgsdr 541 sneleirgky vvvpetsqdm afkcpicket vtgvydeesg ewvwkntiev ngkyfhstcy 601 hetsqnssks nsgkvglddl kklvtk // LOCUS NP_010515 453 aa linear PLN 30-JUN-2025 DEFINITION Ivy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010515 VERSION NP_010515.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180537.3 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12071. On Jul 30, 2012 this sequence version replaced NP_010515.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..453 /product="Ivy1p" /calculated_mol_wt="49845" CDS 1..453 /gene="IVY1" /locus_tag="YDR229W" /coded_by="NM_001180537.3:1..1362" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:12553664|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:12553664]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:genetic interaction:GO:0042144 vacuole fusion, non-autophagic [PMID:12553664]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:12553664]" /experiment="EXISTENCE:physical interaction:GO:0042144 vacuole fusion, non-autophagic [PMID:12553664]" /note="Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase; contains a putative inverse BAR (I-BAR) domain that can mold lipid bilayer membranes into protrusions" /db_xref="GeneID:851815" /db_xref="SGD:S000002637" ORIGIN 1 mpdnnteqlq gspssdqrlr vdwdngnhfd vspdryaphl sefypivnsk rpvassagse 61 nndhlddmnh lrsskvyska rrassitsgt stindlqtli tkrdvketqe alstllrnsn 121 aysdsllkts qngaeiahsl eniaklkgcn detaekllsa sglfyllsnh qlimskyfnd 181 llgdnliddi defelqtkim enkfkaqske qslklklqer hnfdiskrki rnlisyresl 241 sslqarldql etlkhdfymd syelventcn kvlskvatvs raqveiseni arkgwsgggl 301 dellcdaddp fskkadgpyg tiggdgetag eaynsdeetg gndvvlnell egtsqpstsk 361 tslpkskgss tvstpnhsqs ssnkdgvrnn gggkngeded tdnlmgtens fslpptrnsa 421 eettqtfkql sikedndnhs sdtdgmqdqs sni // LOCUS NP_010517 205 aa linear PLN 30-JUN-2025 DEFINITION Cox20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010517 VERSION NP_010517.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180539.1 REFERENCE 1 (residues 1 to 205) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 205) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 205) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 205) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12072. Method: conceptual translation. FEATURES Location/Qualifiers source 1..205 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..205 /product="Cox20p" /calculated_mol_wt="23627" Region 62..164 /region_name="Cox20" /note="Cytochrome c oxidase assembly protein COX20; pfam12597" /db_xref="CDD:403707" CDS 1..205 /gene="COX20" /locus_tag="YDR231C" /coded_by="NM_001180539.1:1..618" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10671482]" /experiment="EXISTENCE:direct assay:GO:0043069 negative regulation of programmed cell death [PMID:31752220]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:10671482]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:10671482]" /experiment="EXISTENCE:mutant phenotype:GO:0043069 negative regulation of programmed cell death [PMID:31752220]" /note="Mitochondrial inner membrane protein; required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase" /db_xref="GeneID:851817" /db_xref="SGD:S000002639" ORIGIN 1 mrwwpwsnqt edqkqqqqpq gkadgdrvlt nysrgqkill edtppkfadd lsnsqlakkq 61 eratlkeawd sirwsdfslq kltsipcfrd agmlgfssmf lmgsiifiyh ksptkatnwa 121 msslilgsiv gweqcrlkrq ksfqiaqlak etvakkekpm lhnvphdpsl pgqweaakne 181 kqsqfeqsnq nlsqassekk wykfw // LOCUS NP_010518 548 aa linear PLN 30-JUN-2025 DEFINITION 5-aminolevulinate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010518 VERSION NP_010518.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180540.1 REFERENCE 1 (residues 1 to 548) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 548) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 548) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 548) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12073. Method: conceptual translation. FEATURES Location/Qualifiers source 1..548 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..548 /product="5-aminolevulinate synthase" /EC_number="2.3.1.37" /calculated_mol_wt="59231" Region 71..492 /region_name="5aminolev_synth" /note="5-aminolevulinic acid synthase; TIGR01821" /db_xref="CDD:273820" Site order(121,181..183,209,252,256..257,281,283..284,334,337, 461) /site_type="active" /note="substrate-cofactor binding pocket [active]" /db_xref="CDD:99747" Site order(181..183,209,252,256,281,283..284,334,337) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99747" Site 337 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99747" CDS 1..548 /gene="HEM1" /locus_tag="YDR232W" /gene_synonym="CYD1; OLE3" /coded_by="NM_001180540.1:1..1647" /experiment="EXISTENCE:direct assay:GO:0003870 5-aminolevulinate synthase activity [PMID:6381051]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:3023841]" /experiment="EXISTENCE:mutant phenotype:GO:0003870 5-aminolevulinate synthase activity [PMID:24173275|PMID:7035824|PMID:323256]" /experiment="EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:7035824|PMID:323256]" /experiment="EXISTENCE:mutant phenotype:GO:1902117 positive regulation of organelle assembly [PMID:32075909]" /note="5-aminolevulinate synthase; catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p; has a pyridoxal phosphate cofactor whose insertion is mediated by Mcx1p" /db_xref="GeneID:851818" /db_xref="SGD:S000002640" ORIGIN 1 mqrsifarfg nssaavstln rlsttaapha kngyatatga gaaaatatas sthaaaaaaa 61 aanhstqesg fdyeglidse lqkkrldksy ryfnninrla kefplahrqr eadkvtvwcs 121 ndylalskhp evldamhkti dkygcgaggt rniaghnipt lnleaelatl hkkegalvfs 181 scyvandavl sllgqkmkdl vifsdelnha smivgikhan vkkhifkhnd lneleqllqs 241 ypksvpklia fesvysmags vadiekicdl adkygaltfl devhavglyg phgagvaehc 301 dfeshrasgi atpktndkgg aktvmdrvdm itgtlgksfg svggyvaasr klidwfrsfa 361 pgfiftttlp psvmagataa iryqrchidl rtsqqkhtmy vkkafhelgi pvipnpshiv 421 pvlignadla kqasdilink hqiyvqainf ptvargterl ritptpghtn dlsdilinav 481 ddvfnelqlp rvrdwesqgg llgvgesgfv eesnlwtssq lsltnddlnp nvrdpivkql 541 evssgikq // LOCUS NP_010519 295 aa linear PLN 30-JUN-2025 DEFINITION Rtn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010519 VERSION NP_010519.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180541.3 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12074. On Jul 30, 2012 this sequence version replaced NP_010519.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..295 /product="Rtn1p" /calculated_mol_wt="32785" Region 21..178 /region_name="Reticulon" /note="pfam02453" /db_xref="CDD:460562" CDS 1..295 /gene="RTN1" /locus_tag="YDR233C" /coded_by="NM_001180541.3:1..888" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16002643|PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:16624861]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:16002643]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:16624861]" /experiment="EXISTENCE:direct assay:GO:0071782 endoplasmic reticulum tubular network [PMID:16469703]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0032581 ER-dependent peroxisome organization [PMID:27129769]" /experiment="EXISTENCE:genetic interaction:GO:0034976 response to endoplasmic reticulum stress [PMID:27117666]" /experiment="EXISTENCE:genetic interaction:GO:0048309 endoplasmic reticulum inheritance [PMID:27117666]" /experiment="EXISTENCE:genetic interaction:GO:0051292 nuclear pore complex assembly [PMID:19273614]" /experiment="EXISTENCE:genetic interaction:GO:0071786 endoplasmic reticulum tubular network organization [PMID:18442980|PMID:19665976|PMID:18309084|PMID:16469703]" /experiment="EXISTENCE:genetic interaction:GO:0071788 endoplasmic reticulum tubular network maintenance [PMID:21502358]" /experiment="EXISTENCE:physical interaction:GO:0071786 endoplasmic reticulum tubular network organization [PMID:19665976]" /note="Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; increases tubular ER when overexpressed; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; member of the RTNLA subfamily" /db_xref="GeneID:851819" /db_xref="SGD:S000002641" ORIGIN 1 msasaqhsqa qqqqqqkscn cdlllwrnpv qtgkyfggsl lallilkkvn litfflkvay 61 tilfttgsie fvsklflgqg litkygpkec pniagfikph idealkqlpv fqahirktvf 121 aqvpkhtfkt avalfllhkf fswfsiwtiv fvadiftftl pviyhsykhe idatvaqgve 181 iskqktqefs qmacektkpy ldkvesklgp isnlvkskta pvsstagpqt astsklaadv 241 plepeskayt ssaqvmpevp qhepsttqef nvdelsnelk kstknlqnel eknna // LOCUS NP_010520 693 aa linear PLN 30-JUN-2025 DEFINITION homoaconitate hydratase LYS4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010520 VERSION NP_010520.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180542.3 REFERENCE 1 (residues 1 to 693) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 693) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 693) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 693) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12075. On Jul 30, 2012 this sequence version replaced NP_010520.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..693 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..693 /product="homoaconitate hydratase LYS4" /EC_number="4.2.1.36" /calculated_mol_wt="75020" Region 20..693 /region_name="h_aconitase" /note="homoaconitase; TIGR00139" /db_xref="CDD:129245" CDS 1..693 /gene="LYS4" /locus_tag="YDR234W" /gene_synonym="LYS3" /coded_by="NM_001180542.3:1..2082" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14562095|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:2507177]" /note="Homoaconitase; catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway" /db_xref="GeneID:851820" /db_xref="SGD:S000002642" ORIGIN 1 mlrsttftrs fhssrawlkg qnltekivqs yavnlpegkv vhsgdyvsik pahcmshdns 61 wpvalkfmgl gatkiknpsq ivttldhdiq nkseknltky knienfakkh hidhypagrg 121 ighqimieeg yafplnmtva sdshsntygg lgslgtpivr tdaaaiwatg qtwwqippva 181 qvelkgqlpq gvsgkdiiva lcglfnndqv lnhaieftgd slnalpidhr ltianmttew 241 galsglfpvd ktlidwyknr lqklgtnnhp rinpktiral eekakipkad kdahyakkli 301 idlatlthyv sgpnsvkvsn tvqdlsqqdi kinkaylvsc tnsrlsdlqs aadvvcptgd 361 lnkvnkvapg vefyvaaass eieadarksg awekllkagc iplpsgcgpc iglgagllep 421 gevgisatnr nfkgrmgskd alaylaspav vaasavlgki sspaevlsts eipfsgvkte 481 iienpvveee vnaqteapkq sveilegfpr efsgelvlcd adnintdgiy pgkytyqddv 541 pkekmaqvcm enydaefrtk vhpgdivvsg fnfgtgssre qaatallakg inlvvsgsfg 601 nifsrnsinn alltleipal ikklrekyqg apkeltrrtg wflkwdvada kvvvtegsld 661 gpvileqkvg elgknlqeii vkgglegwvk sql // LOCUS NP_010521 544 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein PRP42 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010521 VERSION NP_010521.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180543.1 REFERENCE 1 (residues 1 to 544) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 544) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 544) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 544) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12076. Method: conceptual translation. FEATURES Location/Qualifiers source 1..544 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..544 /product="mRNA splicing protein PRP42" /calculated_mol_wt="65014" Region 56..>183 /region_name="RNA14" /note="Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]; COG5107" /db_xref="CDD:227438" CDS 1..544 /gene="PRP42" /locus_tag="YDR235W" /gene_synonym="MUD16; SNU65" /coded_by="NM_001180543.1:1..1635" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9418882]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9418882]" /note="U1 snRNP protein involved in splicing; required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats" /db_xref="GeneID:851821" /db_xref="SGD:S000002643" ORIGIN 1 mdkytalihd enfstltlnv srypkslayw ekllnyivka sapickstep qllklircty 61 ssmlnefpyl enyyidfall eyklgnvsms hkifqrglqa fnqrslllwt sylkfcnnvi 121 shqkqlfkky etaeeyvglh ffsgefwdly leqissrcts skkywnvlrk ileiplhsfs 181 kfyalwlqri ddimdlkqls qltskdellk klkidinysg rkgpylqdak kklkkitkem 241 ymvvqyqvle iysifeskiy inyytspetl vssdeietwi kyldytitlq tdslthlnfq 301 rallplahyd lvwikyskwl inskndllga knvllmglkf slkkteiikl lysvicklne 361 yvllrnllek iessysdnve nvddfeifwd ylqfktfcqn slyssrysds qsngllnkel 421 fdkvwkrlsc kekksgqeil lnnlvqfysk dtvefvekni fqkiiefgwe yylqngmfwn 481 cycrliyfdt srsyldkrqy ivrkiwpqid kkfaqsvlps ltefcesyfp eemdtleemf 541 teep // LOCUS NP_010522 218 aa linear PLN 30-JUN-2025 DEFINITION riboflavin kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010522 VERSION NP_010522.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180544.1 REFERENCE 1 (residues 1 to 218) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 218) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 218) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 218) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12077. Method: conceptual translation. FEATURES Location/Qualifiers source 1..218 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..218 /product="riboflavin kinase" /EC_number="2.7.1.26" /calculated_mol_wt="24406" Region 57..206 /region_name="Flavokinase" /note="Riboflavin kinase; pfam01687" /db_xref="CDD:460295" CDS 1..218 /gene="FMN1" /locus_tag="YDR236C" /coded_by="NM_001180544.1:1..657" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10887197]" /experiment="EXISTENCE:direct assay:GO:0008531 riboflavin kinase activity [PMID:10887197]" /experiment="EXISTENCE:direct assay:GO:0009398 FMN biosynthetic process [PMID:10887197]" /experiment="EXISTENCE:direct assay:GO:0043231 intracellular membrane-bounded organelle [PMID:10887197]" /experiment="EXISTENCE:mutant phenotype:GO:0008531 riboflavin kinase activity [PMID:10887197]" /experiment="EXISTENCE:mutant phenotype:GO:0009398 FMN biosynthetic process [PMID:10887197]" /note="Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane; human RFK functionally complements the lethality of the null mutation" /db_xref="GeneID:851822" /db_xref="SGD:S000002644" ORIGIN 1 mftwtiyvsl llvlagtflm nrntntdiid tfkrevdlpi paqpgppfpl vtdycdivcg 61 fgrgsaelgi ptanvpinql pkgindldlg vyfgfahikt vdgqelsvet rrdgrtvvyn 121 ygqylseand dlsvlpmvls vgknpfygnd fktmelhiih dfkndfygar vkfnilghir 181 pelnyttkea liedinidir taqtvlatpp yqvfkqql // LOCUS NP_010523 292 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL5m MRPL7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010523 VERSION NP_010523.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180545.3 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12078. On Jul 30, 2012 this sequence version replaced NP_010523.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..292 /product="mitochondrial 54S ribosomal protein uL5m MRPL7" /calculated_mol_wt="32968" Region 133..186 /region_name="Ribosomal_L5" /note="Ribosomal protein L5; pfam00281" /db_xref="CDD:425579" Region 191..287 /region_name="Ribosomal_L5_C" /note="ribosomal L5P family C-terminus; pfam00673" /db_xref="CDD:459899" CDS 1..292 /gene="MRPL7" /locus_tag="YDR237W" /gene_synonym="uL5m" /coded_by="NM_001180545.3:1..879" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein" /db_xref="GeneID:851823" /db_xref="SGD:S000002645" ORIGIN 1 mqrfslvthr sfshscvkpk sacslvkpvh hlvkidkskl sprfpelkyd ksdirspgfk 61 pkdthadrln dhylntlqsd lllinyshna avvkglkqra wsgdspyhln rppknprgsk 121 aqlpdihpik wsnipglesv vincfvrear enqllaitaa lqlqqitgck phpifskndv 181 ptwklrkghq mgakvelkgk emsqflstlt eivlprirey kgisnqsgnr fggisfglta 241 edikffpeid anqdswpktf gmhinintsa qldyqartll sgfqfpffge ek // LOCUS NP_010524 973 aa linear PLN 30-JUN-2025 DEFINITION coatomer subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_010524 VERSION NP_010524.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180546.3 REFERENCE 1 (residues 1 to 973) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 973) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 973) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 973) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 973) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 973) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 973) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 973) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 973) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12079. On Jul 30, 2012 this sequence version replaced NP_010524.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..973 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..973 /product="coatomer subunit beta" /calculated_mol_wt="108889" Region 1..941 /region_name="COG5096" /note="Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]" /db_xref="CDD:227427" CDS 1..973 /gene="SEC26" /locus_tag="YDR238C" /coded_by="NM_001180546.3:1..2922" /experiment="EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:21435344]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:7929113]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:27068463]" /note="Essential beta-coat protein of the COPI coatomer; involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)" /db_xref="GeneID:851824" /db_xref="SGD:S000002646" ORIGIN 1 mtslssqpay tlvfdpspsm etysstdfqk alekgsdeqk idtmksilvt mlegnpmpel 61 lmhiirfvmp sknkelkkll yfyweivpkl aedgklrhem ilvcnaiqhd lqhpneyirg 121 ntlrfltklr eaelleqmvp svlacleyrh ayvrkyaila vfsifkvseh llpdakeiin 181 sfivaetdpi ckrnafigla eldrenalhy lenniadien ldpllqavfv qfirqdanrt 241 palkaqyiel lmellsttts devifetala ltvlsanpnv lvpavnklid lavkvsdnni 301 klivldriqd inannvgale eltldilrvl naedldvrsk aldismdlat srnaedvvql 361 lkkelqttvn npdqdkamqy rqlliktirt vavnfvemaa svvsllldfi gdlnsvaasg 421 iiafikevie kypqlranil enmvqtldkv rsakayrgal wimgeyaege seiqhcwkhi 481 rnsvgevpil qseikkltqn qehteenevd atakptgpvi lpdgtyates afdvktsqks 541 vtdeerdsrp pirrfvlsgd fytaailant iiklvlkfen vsknktvina lkaeallilv 601 sivrvgqssl vekkidedsl ervmtsisil ldevnpeekk eevkllevaf ldttkssfkr 661 qieiakknkh kralkdsckn iepidtpisf rqfagvdstn vqkdsieedl qlamkgdaih 721 atssssiskl kkivplcgfs dpvyaeacit nnqfdvvldv llvnqtketl knlhvqfatl 781 gdlkiidtpq ktnviphgfh kftvtvkvss adtgvifgni iydgahgeda ryvilndvhv 841 dimdyikpat addehfrtmw nafewenkis vksqlptlha ylrelvkgtn mgiltpsesl 901 geddcrflsc nlyakssfge dalanlciek dsktndvigy vrirskgqgl alslgdrval 961 iakktnklal thv // LOCUS NP_010525 787 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR239C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010525 VERSION NP_010525.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180547.1 REFERENCE 1 (residues 1 to 787) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 787) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 787) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 787) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12080. Method: conceptual translation. FEATURES Location/Qualifiers source 1..787 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..787 /product="uncharacterized protein" /calculated_mol_wt="86303" CDS 1..787 /locus_tag="YDR239C" /coded_by="NM_001180547.1:1..2364" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments" /db_xref="GeneID:851825" /db_xref="SGD:S000002647" ORIGIN 1 mfdgfsnnkg krrsffrfgs esknndseks vrkpsvpsti kkstniarts taetsapdip 61 prspnrnahs rshsiqaplq ketlkntnpf lnaedtlgds leltqskeas gndhkgieyl 121 qenniigqrt npfttsansn ahfskikrsr pppppmdmks ittsisnntt keeiesnnds 181 erdsiaisst hnqhrrqrse aeklvddien yinehkvssg sslsldtsen sdtkasqdkl 241 pvdvmeapil rnvsaessls yvkplivdne evnkasngnl vqsdhlkefs snlddgddkf 301 sfstsasgks tkslqqvskd essgfkaahf dfayksnehl gsdgsiasar kplritneid 361 sgssnedddd glqekgfvds eskafinyas dqgssikndv stqepelpsh rrifrvvned 421 rpsfylnsvn dtgsltdkhs fdtassgeyd aksnfssqsg lsiskgskst vlaaldsngn 481 tkssnktsel nslnsisesl vpaahsfneh tvtipatvdl pnpvhdapse rsvkcsplts 541 vvsnkseksv plvssyveel rlkyyktsnf lqappnlpva lkqknnliqp knikvklrts 601 skqigikhgk vkqkllalet rneesdgtat glknkinvdh tkefhkllgk enetgsiskk 661 egtdaeqaed ylkdipgdea ynsddimapl rekrgqngsv dsvsrsntvv syytrsqnrm 721 rsgtldndyv nrqklpthis lqdyrdanar snisrqdsvs ttnsdvvdls yslghglrva 781 npdsdpe // LOCUS NP_010526 492 aa linear PLN 30-JUN-2025 DEFINITION Snu56p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010526 VERSION NP_010526.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180548.1 REFERENCE 1 (residues 1 to 492) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 492) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 492) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 492) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12081. Method: conceptual translation. FEATURES Location/Qualifiers source 1..492 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..492 /product="Snu56p" /calculated_mol_wt="56367" Region 30..491 /region_name="Snu56_snRNP" /note="Snu56-like U1 small nuclear ribonucleoprotein component; pfam19097" /db_xref="CDD:436963" CDS 1..492 /gene="SNU56" /locus_tag="YDR240C" /gene_synonym="MUD10" /coded_by="NM_001180548.1:1..1479" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:physical interaction:GO:0000243 commitment complex [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0003729 mRNA binding [PMID:10072386]" /note="Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex" /db_xref="GeneID:851827" /db_xref="SGD:S000002648" ORIGIN 1 mrprrrglay hhtkpkgqls qghypttsnd gqrrkvgnse afqsfdiwkn ldrirstkkn 61 agqfikgsll ilpmrtedkq qfdecmdelh kyiskdilrc ypqkeqkdeg mlfyivlkdf 121 nildscfvls vllafqkrlw mapseksyfr vpkninltgs fylpknietg rghiitsyrr 181 eqpsssivev gfnvvpdfqq fqvkachvsk fmnelsnffs qvefgkcean vinyfkreyn 241 rtysqislal yelpligdgl fdiksyiskt rpiietskaq mikhisemka yneisglqgd 301 qfprqqrpls nspssnsiss sqtieagats yqtqpqrhav nkpsnvlnss nrhsgpktfe 361 dgrysegnkp gfmtqdeikq hcigtikasm davkkkssyq ilktyvrcpr qnyidivyqn 421 lndlrsktnc nivvlnlnnl hesqmwlesl nttnytifaq aphpstirvi siggvgeyiv 481 kalelilnil eh // LOCUS NP_010528 549 aa linear PLN 30-JUN-2025 DEFINITION putative amidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010528 VERSION NP_010528.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180550.3 REFERENCE 1 (residues 1 to 549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 549) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12082. On Jul 30, 2012 this sequence version replaced NP_010528.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..549 /product="putative amidase" /EC_number="3.5.1.4" /calculated_mol_wt="61279" Region 79..539 /region_name="Amidase" /note="pfam01425" /db_xref="CDD:396144" CDS 1..549 /gene="AMD2" /locus_tag="YDR242W" /coded_by="NM_001180550.3:1..1650" /note="Putative amidase" /db_xref="GeneID:851829" /db_xref="SGD:S000002650" ORIGIN 1 mtvhstwkek vqlkkdqlns kikdewklns ttitrlkndk knlikniddl csssenqith 61 stimalrqal eakelschei taafchraal ihqvvnclse imfsealrla dyydsnrpai 121 lpplygipis lkdqcnvegv dtslgylcrt fkpktknees livsflrdlg aiifvkttvp 181 ssmmatdtqs ntfgytynsi nlsfssggss ggegsligah gsllglgtdi ggsiripssy 241 qglfglkptf grvpylrvdn sfegretips vigplardls dlryfmscvi nicqpwvqdv 301 kcipyhfdss tsklhdnyvv giwygdgvid pppsdiralk tcedlvnktk gmkavkweps 361 selsrelfdl aneadvadsg neiknefeis geplldilkp mvlengrppy tvnewwdltk 421 rvynaqqlmr dyylsfpese rpdviisptt lmpfrpgdml kttlryillf nvlnfpslsi 481 pvgsvdcqid glmdttsaln pedkmiktyw ndliqsgeid gfpiglqvvs ptfndnevck 541 faswlfski // LOCUS NP_010529 588 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein PRP28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010529 VERSION NP_010529.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180551.3 REFERENCE 1 (residues 1 to 588) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 588) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 588) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 588) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12083. On Jul 30, 2012 this sequence version replaced NP_010529.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..588 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..588 /product="mRNA splicing protein PRP28" /EC_number="3.6.4.13" /calculated_mol_wt="66510" Region 175..559 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..588 /gene="PRP28" /locus_tag="YDR243C" /coded_by="NM_001180551.3:1..1767" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:23462954]" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284]" /experiment="EXISTENCE:mutant phenotype:GO:0000384 first spliceosomal transesterification activity [PMID:7520570]" /experiment="EXISTENCE:mutant phenotype:GO:0000395 mRNA 5'-splice site recognition [PMID:23462954]" /note="Pre-mRNA splicing factor; RNA binding protein involved in RNA isomerization at the 5' splice site and for exchange of U6 for U1 snRNA at the 5' splice site; similar to the RNA helicases of the DEAD-box family" /db_xref="GeneID:851830" /db_xref="SGD:S000002651" ORIGIN 1 marpidvsql iaginkkkgl dentsgkisk prflnkqers kqerlkenee sltptqsdsa 61 kveikkvnsr ddsffnetnd kkrnpskqng skfhfswnes edtlsgydpi vstraidllw 121 kgktpknaae ssymgkhwte kslhemnerd wrilkedyai vtkggtvenp lrnweelnii 181 prdllrviiq elrfpsptpi qritipnvcn mkqyrdflgv astgsgktla fvipilikms 241 rspprppslk iidgpkalil aptrelvqqi qketqkvtki wskesnydck visivgghsl 301 eeisfslseg cdilvatpgr lidslenhll vmkqvetlvl deadkmidlg fedqvtnilt 361 kvdinadsav nrqtlmftat mtpviekiaa gymqkpvyat igvetgsepl iqqvveyadn 421 dedkfkklkp ivakydppii ifinykqtad wlaekfqket nmkvtilhgs ksqeqrehsl 481 qlfrtnkvqi miatnvaarg ldipnvslvv nfqiskkmdd yihrigrtgr aanegtavsf 541 vsaaedesli relykyvrkh dplnsnifse avknkynvgk qlsneiiy // LOCUS NP_010530 612 aa linear PLN 30-JUN-2025 DEFINITION Pex5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010530 VERSION NP_010530.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180552.1 REFERENCE 1 (residues 1 to 612) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 612) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 612) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 612) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12084. Method: conceptual translation. FEATURES Location/Qualifiers source 1..612 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..612 /product="Pex5p" /calculated_mol_wt="69193" Region <193..314 /region_name="PTZ00341" /note="Ring-infected erythrocyte surface antigen; Provisional" /db_xref="CDD:173534" Region 262..430 /region_name="NlpI" /note="Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis]; COG4785" /db_xref="CDD:443815" Site order(316..317,320..321,323,348,351..352,355..356,358..359, 382,385..386,389..390,393) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 316..341 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 340..>548 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" Region 346..376 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 381..409 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 457..485 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(458,461..462,465..466,468,492,495..496,499..500, 502..503,526,529..530,533..534,537) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 490..520 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 525..553 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..612 /gene="PEX5" /locus_tag="YDR244W" /gene_synonym="PAS10" /coded_by="NM_001180552.1:1..1839" /experiment="EXISTENCE:direct assay:GO:0005052 peroxisome matrix targeting signal-1 binding [PMID:35768507|PMID:7980572]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:15632140]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:16849337]" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:15283676]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15283676|PMID:8858166]" /experiment="EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0016558 protein import into peroxisome matrix [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0016560 protein import into peroxisome matrix, docking [PMID:9094717]" /experiment="EXISTENCE:direct assay:GO:0016561 protein import into peroxisome matrix, translocation [PMID:20154681]" /experiment="EXISTENCE:direct assay:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:35768507|PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:0043335 protein unfolding [PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:0044721 protein import into peroxisome matrix, substrate release [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0140597 protein carrier chaperone [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:22375831]" /experiment="EXISTENCE:genetic interaction:GO:0016558 protein import into peroxisome matrix [PMID:27678487]" /experiment="EXISTENCE:mutant phenotype:GO:0005052 peroxisome matrix targeting signal-1 binding [PMID:11154700]" /experiment="EXISTENCE:mutant phenotype:GO:0016560 protein import into peroxisome matrix, docking [PMID:16849337]" /experiment="EXISTENCE:physical interaction:GO:0005778 peroxisomal membrane [PMID:8858166]" /experiment="EXISTENCE:physical interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:12595255|PMID:16849337]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:15798189]" /note="Peroxisomal membrane signal receptor for peroxisomal matrix proteins; receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins; required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions" /db_xref="GeneID:851831" /db_xref="SGD:S000002652" ORIGIN 1 mdvgscsvgn nplaqlhkht qqnkslqfnq knngrlnesp lqgtnkpgis eafisnvnai 61 sqenmanmqr fingeplidd krrmeigpss grlppfsnvh slqtsanptq ikgvndishw 121 sqefqgsnsi qnrnadtgns ekawqrgstt assrfqypnt mmnnyayasm nslsgsrlqs 181 pafmnqqqsg rskegvneqe qqpwtdqfek lekevsenld indeiekeen vseveqnkpe 241 tvekeegvyg dqyqsdfqev wdsihkdaee vlpselvndd lnlgedylky lggrvngnie 301 yafqsnneyf nnpnaykigc llmengakls eaalafeaav kekpdhvdaw lrlglvqtqn 361 ekelngisal eeclkldpkn leamktlais yinegydmsa ftmldkwaet kypeiwsrik 421 qqddkfqkek gfthidmnah itkqflqlan nlstidpeiq lclgllfytk ddfdktidcf 481 esalrvnpnd elmwnrlgas lansnrseea iqayhralql kpsfvraryn lavssmnigc 541 fkeaagylls vlsmhevntn nkkgdvgsll ntyndtviet lkrvfiamnr ddllqevkpg 601 mdlkrfkgef sf // LOCUS NP_010531 393 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010531 VERSION NP_010531.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180553.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12085. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..393 /product="alpha-1,6-mannosyltransferase" /calculated_mol_wt="46617" Region 118..368 /region_name="Glyco_transf_34" /note="galactosyl transferase GMA12/MNN10 family; pfam05637" /db_xref="CDD:368535" CDS 1..393 /gene="MNN10" /locus_tag="YDR245W" /gene_synonym="BED1; REC41; SLC2" /coded_by="NM_001180553.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:10037752]" /experiment="EXISTENCE:direct assay:GO:0000136 mannan polymerase complex [PMID:10037752]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:10037752]" /experiment="EXISTENCE:mutant phenotype:GO:0000917 division septum assembly [PMID:16034811]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:8991513|PMID:23210626]" /note="Subunit of a Golgi mannosyltransferase complex; complex mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family; other members of the complex are Anp1p, Mnn9p, Mnn11p, and Hoc1p" /db_xref="GeneID:851832" /db_xref="SGD:S000002653" ORIGIN 1 mssvpynsql pisnhleyde dekksrgskl glkykmiywr ktlcsslarw rklillisla 61 lflfiwisds tisrnpstts fqgqnsndnk lsntgssins kryvppyskr srwsfwnqdp 121 riviilaane gggvlrwkne qewaiegisi enkkayakrh gyaltikdlt tskrysheyr 181 egwqkvdilr qtfrefpnae wfwwldldtm imepskslee hifdrletla drelksfnpl 241 nlrddipyvd yseemeflit qdcggfnlgs fliknsewsk llldmwwdpv lyeqkhmvwe 301 hreqdaleal yenepwirsr igflplrtin afppgacsey sgdsryfyse kdhdfvvnma 361 gcnfgrdcwg emqyyttlme klnrkwytrf ffp // LOCUS NP_010532 219 aa linear PLN 30-JUN-2025 DEFINITION TRAPP subunit TRS23 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010532 VERSION NP_010532.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180554.3 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12086. On Jul 30, 2012 this sequence version replaced NP_010532.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..219 /product="TRAPP subunit TRS23" /calculated_mol_wt="24732" Region 1..218 /region_name="TRS23" /note="Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion]; COG5122" /db_xref="CDD:227451" CDS 1..219 /gene="TRS23" /locus_tag="YDR246W" /coded_by="NM_001180554.3:1..660" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17110339]" /experiment="EXISTENCE:direct assay:GO:1990070 TRAPPI protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990072 TRAPPIII protein complex [PMID:20375281]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9564032]" /experiment="EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17287728]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11239471]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18439903]" /note="Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homolog is TRAPPC4" /db_xref="GeneID:851833" /db_xref="SGD:S000002654" ORIGIN 1 maietilvin ksggliyqrn ftndeqklns neylilastl hgvfaiasql tpkalqltqq 61 tnientipyi pyvgmssnrs dtrngggnnn khtnneklgs fkgddffkep ftnwnksglr 121 qlctdqftmf iyqtltglkf vaisssvmpq rqptiattdk pdrpkstsnl aiqiadnflr 181 kvyclysdyv mkdpsysmem pirsnlfdek vkkmvenlq // LOCUS NP_878065 66 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR246W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878065 VERSION NP_878065.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184547.3 REFERENCE 1 (residues 1 to 66) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 66) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 66) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 66) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12087. On Jul 30, 2012 this sequence version replaced NP_878065.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..66 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..66 /product="uncharacterized protein" /calculated_mol_wt="7536" CDS 1..66 /locus_tag="YDR246W-A" /coded_by="NM_001184547.3:1..201" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466436" /db_xref="SGD:S000028542" ORIGIN 1 mrrlyrhlas ffllpscpgn tiqsitsypa nallrsfrhv stetpvrnrv hnrdsqscpf 61 fplmdd // LOCUS NP_010533 461 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase VHS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010533 VERSION NP_010533.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180555.1 REFERENCE 1 (residues 1 to 461) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 461) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 461) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 461) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12088. Method: conceptual translation. FEATURES Location/Qualifiers source 1..461 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..461 /product="putative serine/threonine protein kinase VHS1" /EC_number="2.7.11.1" /calculated_mol_wt="52005" Region 11..330 /region_name="STKc_Pat1_like" /note="Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; cd13993" /db_xref="CDD:270895" Site order(18..22,26,39,41,122,138..141,144,146,185,187, 189..190,192,203,206,220..223) /site_type="active" /db_xref="CDD:270895" Site order(18..22,26,39,41,122,138..141,144,185,187,189..190, 192,203) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270895" Site order(22,144,146,185,187,189,206,220..223) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270895" Site order(202..212,214..223) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270895" CDS 1..461 /gene="VHS1" /locus_tag="YDR247W" /coded_by="NM_001180555.1:1..1386" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:29249654]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12518319]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:29249654]" /note="Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; VHS1 has a paralog, SKS1, that arose from the whole genome duplication" /db_xref="GeneID:851834" /db_xref="SGD:S000002655" ORIGIN 1 mmmfhncrin nylitsqige gayglvyral dirtdrqyai kavvqsygvs keadmgndki 61 hknsvklqkk laklfkeskn vvrvpsidle sienmseedf kklphykeis lhlrvhhhkn 121 ivtihevlqs avctfivmdy yptdlftsiv dnrhfvtngl lvkkvflqic salnychehg 181 iyhcdikpen llldtednvf lcdfglstts tyikpnvcig ssyympperi sfdgrvsssk 241 sgghklgkvc pscngdlwsl giilinltci rnpwlkadkt edntyyyftk dpnilkqilp 301 lsddfyslls kilqvnpknr mslqelmkev ssitsftneg plskvpplsk svyekfvspv 361 dntnenlspk syvymhdska aknlsytsss eeedgikegi dddngsrsgs fgtldtdtgl 421 hssftstsce sdnecskisn kfslfekkfn elrmsssslt n // LOCUS NP_010534 193 aa linear PLN 30-JUN-2025 DEFINITION gluconokinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010534 VERSION NP_010534.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180556.1 REFERENCE 1 (residues 1 to 193) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 193) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 193) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 193) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12089. Method: conceptual translation. FEATURES Location/Qualifiers source 1..193 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..193 /product="gluconokinase" /EC_number="2.7.1.12" /calculated_mol_wt="22044" Region 14..186 /region_name="therm_gnt_kin" /note="carbohydrate kinase, thermoresistant glucokinase family; TIGR01313" /db_xref="CDD:273551" Site order(18..25,46,48,132,136) /site_type="other" /note="ATP-binding site [chemical binding]" /db_xref="CDD:238979" Site order(20..21,136) /site_type="other" /note="Gluconate-6-phosphate binding site [chemical binding]" /db_xref="CDD:238979" CDS 1..193 /locus_tag="YDR248C" /coded_by="NM_001180556.1:1..582" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0046316 gluconokinase activity [PMID:26279678]" /note="Putative gluconokinase; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1" /db_xref="GeneID:851835" /db_xref="SGD:S000002656" ORIGIN 1 mtekhktmgk fkvivlagta gtgkstiage lihefkdiyp dlkfiegddl hppanvekmt 61 rgiplndddr wdwlkkvave stkaaastke hlsivacssl kkkyrdlirh tcpesefhfi 121 flyaskievl krlktrkghf mkadmmesqf rdlelpdind etdcdivpld fktfyqiekd 181 viqvvkskvl nie // LOCUS NP_010535 373 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR249C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010535 VERSION NP_010535.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180557.3 REFERENCE 1 (residues 1 to 373) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 373) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 373) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 373) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12090. On Jul 30, 2012 this sequence version replaced NP_010535.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..373 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..373 /product="uncharacterized protein" /calculated_mol_wt="43659" CDS 1..373 /locus_tag="YDR249C" /coded_by="NM_001180557.3:1..1122" /note="hypothetical protein" /db_xref="GeneID:851836" /db_xref="SGD:S000002657" ORIGIN 1 mgyiltgyss rhdkrkkhal plhryasssi nlqhhvhlle trvsskrpis edqrtirlpa 61 kklrhhqklt lqdlpveiiq hifvftkgep smvtlnrffy sclkpsfsll skimwekylf 121 dplefgvsni kaysrnivip tlfehetffr llldhhpill knishflprk hyqdmqngdf 181 dtskeldlcs mntedtsked fpknfynnmh ifltrrecvk slgnhftlkn pydvispfie 241 wffqgidmqg tdlspkftfv slfesidlil yvsgstvqkl asieplttvi fllyftyads 301 lgslnfeffl qnrsrlqlie kfilkyyynp sltenellsd stiwdllrrv sdlklidlvv 361 kcggrpqygv mfa // LOCUS NP_010537 830 aa linear PLN 30-JUN-2025 DEFINITION Pam1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010537 VERSION NP_010537.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180559.3 REFERENCE 1 (residues 1 to 830) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 830) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 830) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 830) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12091. On Jul 30, 2012 this sequence version replaced NP_010537.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..830 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..830 /product="Pam1p" /calculated_mol_wt="92741" CDS 1..830 /gene="PAM1" /locus_tag="YDR251W" /coded_by="NM_001180559.3:1..2493" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:32491201]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:32491201|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:8106383]" /note="Essential hypothetical protein; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype; PAM1 has a paralog, SVL3, that arose from the whole genome duplication" /db_xref="GeneID:851838" /db_xref="SGD:S000002659" ORIGIN 1 mtsalrvlvc gdhpnlilyt srfqhaknie fylvnnskna nyevsslfyg terfqiqnhf 61 qslldlvdln nengglvfdl iimsasslqe ipqvlrdikp mmnkttkilf essgfiylep 121 fikasvdlsl snifsiftdy dirrldngsy kqfttanaks fsvsigqtts vhensyssdi 181 ipilntfqkl fqklfprdvv tlydhspsaf lakewelalp qicfdpllii leeknpstld 241 dhvlakplis gllgesllii kkmgiamnnp nfqneqtilk hwknkcedlp dgpallynfi 301 hkasslnidl lllqpillad dfgvktpyle clftmmtqyq llnkgdsewf irkdentalt 361 rvddlqnsia lkdgkimqlq nsestlknei kelqsqvlsl kqevssskan ngqeleilkk 421 kvqmgdnslf drpnsntngi spsdnivdvd lnyersdqgn nssgndsrrq sffnstsdtt 481 lsrdetslke relevrmkel elqerelelq rkalqqqqqy qqrppkqvys gpsgtptsgn 541 nnnksynpnr kssysqpqhv ammtsrglhg psaassspvi sannfvdpvs sgtpyssnss 601 rfsqqipsqq ymhtvkptsr knrssvmpni gyvpgltnne ygrkfngngm ngtqsrlnsl 661 snqstfrsqq gppitqqksf qnnggsmrtn ripsanynis nqqsgfvnsi sspnlsnlen 721 rntvqnsrna dsapcvnqln sdsppqlqsl sqngtskvpq initqpspiq tnfatsdnpa 781 aviklgtpse dtvsaaatan nistmgdesr kedvkekkkk kfsffgkrkk // LOCUS NP_010538 149 aa linear PLN 30-JUN-2025 DEFINITION CCR4-NOT core subunit BTT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010538 VERSION NP_010538.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180560.1 REFERENCE 1 (residues 1 to 149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 149) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12092. Method: conceptual translation. FEATURES Location/Qualifiers source 1..149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..149 /product="CCR4-NOT core subunit BTT1" /calculated_mol_wt="16489" Region 9..125 /region_name="NAC_BTF3" /note="basal transcription factor BTF3; cd22055" /db_xref="CDD:409234" Site order(24..26,29..30) /site_type="other" /note="ribosome binding motif" /db_xref="CDD:409234" Site order(57..67,72,74,86..92,94,108..110) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:409234" CDS 1..149 /gene="BTT1" /locus_tag="YDR252W" /coded_by="NM_001180560.1:1..450" /experiment="EXISTENCE:direct assay:GO:0005854 nascent polypeptide-associated complex [PMID:10219998]" /experiment="EXISTENCE:genetic interaction:GO:0006613 cotranslational protein targeting to membrane [PMID:10518932]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:10219998]" /experiment="EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:18214544]" /note="Heterotrimeric nascent polypeptide-associated complex beta3 subunit; complex binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3; BTT1 has a paralog, EGD1, that arose from the whole genome duplication" /db_xref="GeneID:851839" /db_xref="SGD:S000002660" ORIGIN 1 mpvdqeklak lhklsaankv ggtrrkinkk gnlynnndkd ntklqaelhk lhpmtienva 61 eanffkkngk vlhfnsavvq iapqcnltmi hgqpkentln glypsvasql gsqeleyltg 121 lahnleneqt vldqlgdrcs etkqqvmns // LOCUS NP_010539 191 aa linear PLN 30-JUN-2025 DEFINITION Met32p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010539 VERSION NP_010539.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180561.1 REFERENCE 1 (residues 1 to 191) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 191) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 191) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 191) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12093. Method: conceptual translation. FEATURES Location/Qualifiers source 1..191 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..191 /product="Met32p" /calculated_mol_wt="21387" Region <41..191 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 100..120 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 128..144 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..191 /gene="MET32" /locus_tag="YDR253C" /coded_by="NM_001180561.1:1..576" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9799240]" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:9199298]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9199298]" /experiment="EXISTENCE:direct assay:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:9199298]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:9799240]" /experiment="EXISTENCE:genetic interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9799240]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9199298]" /experiment="EXISTENCE:genetic interaction:GO:0007346 regulation of mitotic cell cycle [PMID:18308733]" /experiment="EXISTENCE:genetic interaction:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:9199298]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:22696683]" /experiment="EXISTENCE:mutant phenotype:GO:0007346 regulation of mitotic cell cycle [PMID:18308733]" /experiment="EXISTENCE:mutant phenotype:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:9199298]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22696683]" /experiment="EXISTENCE:physical interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9799240]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:9799240]" /note="Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; lack of such a loop for MET31 may account for the differential actions of Met32p and Met31p; MET32 has a paralog, MET31, that arose from the whole genome duplication" /db_xref="GeneID:851840" /db_xref="SGD:S000002661" ORIGIN 1 medqdaafik qateaivdvs lnidnidpii kellervrnr qnrlqnkkpa lipaengvdi 61 nsqggnikvk kenalpkppk sskskpqdrr nstgekrfkc akcslefsrs sdlrrhekth 121 failpnicpq cgkgfarkda lkrhydtltc rrnrtkllta ggeginellk kvkqsnivhr 181 qdnnhngssn g // LOCUS NP_010540 458 aa linear PLN 30-JUN-2025 DEFINITION Chl4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010540 VERSION NP_010540.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180562.3 REFERENCE 1 (residues 1 to 458) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 458) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 458) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 458) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12094. On Jul 30, 2012 this sequence version replaced NP_010540.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..458 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..458 /product="Chl4p" /calculated_mol_wt="52541" Region 15..445 /region_name="CENP-N" /note="Kinetochore protein CHL4 like; pfam05238" /db_xref="CDD:398764" CDS 1..458 /gene="CHL4" /locus_tag="YDR254W" /gene_synonym="CTF17; MCM17" /coded_by="NM_001180562.3:1..1377" /experiment="EXISTENCE:direct assay:GO:0000940 outer kinetochore [PMID:12589047]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12642611|PMID:12589047]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:9339342|PMID:8243998]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:22426531]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /experiment="EXISTENCE:mutant phenotype:GO:0034089 establishment of meiotic sister chromatid cohesion [PMID:19730685]" /experiment="EXISTENCE:mutant phenotype:GO:0034090 maintenance of meiotic sister chromatid cohesion [PMID:14752166]" /experiment="EXISTENCE:mutant phenotype:GO:0051382 kinetochore assembly [PMID:12642611]" /experiment="EXISTENCE:mutant phenotype:GO:0071459 protein localization to chromosome, centromeric region [PMID:16357219|PMID:26653857]" /note="Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; forms a stable complex with Iml3p; peripheral component of the Ctf19 kinetochore complex that interacts with Ctf19p, Ctf3p, and Mif2p; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-N and fission yeast mis15" /db_xref="GeneID:851841" /db_xref="SGD:S000002662" ORIGIN 1 msnelrledn yvptsdtlvv fkqlmklpvt vlydltlswf akfggsfdgd iylltetldl 61 liekgvrrnv ivnrilyvyw pdglnvfqla eidchlmisk pekfkwlpsk alrgdgkpyv 121 vklqpakfie nlqtdlakiy hchvymfkhp slpvlitriq lfdsnnlfls tpnigsinke 181 slynkldkfq gkplisrrpy yvafplnspi ifhsvdkdiy arlvlqsisr tiseretiif 241 kpvqkipvks ihnimtllgp srfaesmgpw ecyasanfer splhdykkhq gltgkkvmvr 301 efddsflndd enfygkeepe irrlrleknm ikfkgsangv mdqkyndlke fnehvhnirn 361 gkknedsgep vyisrysslv piekvgftlk neinsriiti klkfngndif gglhelcdkn 421 linidkvpgw lagengsfsg timngdfqre qvakggll // LOCUS NP_010541 421 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein ligase RMD5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010541 VERSION NP_010541.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180563.3 REFERENCE 1 (residues 1 to 421) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 421) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 421) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 421) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12095. On Jul 30, 2012 this sequence version replaced NP_010541.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..421 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..421 /product="ubiquitin-protein ligase RMD5" /EC_number="2.3.2.27" /calculated_mol_wt="49038" Region 13..418 /region_name="COG5109" /note="Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]" /db_xref="CDD:227440" CDS 1..421 /gene="RMD5" /locus_tag="YDR255C" /gene_synonym="GID2" /coded_by="NM_001180563.3:1..1266" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27663510]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12686616]" /experiment="EXISTENCE:direct assay:GO:0034657 GID complex [PMID:12686616|PMID:16872538]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:18508925]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:18508925]" /note="Component of GID Complex that confers ubiquitin ligase (U3) activity; necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; forms dimer with Fyv10p that is then recruited to GID Complex by Gid8p; also required for sporulation; conserved protein that has a degenerate RING finger domain" /db_xref="GeneID:851842" /db_xref="SGD:S000002663" ORIGIN 1 mselldsfet efakfytdsn leetnlqkcl dhthefksql kklkahlnkh iqeskpevyn 61 klsdkekqkf krkreliiek lsksqrqwdh svkkqikyvs qqsnrfnkst lnklkefdid 121 svyvnklpke tmenvneaig yhilrysidn mplgnkneaf qylkdvygit nkestefiem 181 gqivhdlkkg dtesclkwcs nemeslssnh talsslkfdl ytlsamqivk hgnpvelyyq 241 itqnapldcf rhrekelmqn vvplltksli gqpiedidsk vnkelkects lfikeycaak 301 hiffdsplfl ivlsglisfq ffikyktire lahvdwttkd elpfdvklpd flthfhpifi 361 cpvlkeettt enppyslach hiiskkaldr lskngtitfk cpycpvntsm sstkkvrfvm 421 l // LOCUS NP_010542 515 aa linear PLN 30-JUN-2025 DEFINITION catalase A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010542 VERSION NP_010542.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180564.1 REFERENCE 1 (residues 1 to 515) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 515) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 515) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 515) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12096. Method: conceptual translation. FEATURES Location/Qualifiers source 1..515 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..515 /product="catalase A" /EC_number="1.11.1.6" /calculated_mol_wt="58425" Region 47..502 /region_name="catalase_fungal" /note="Fungal catalases similar to yeast catalases A and T; cd08157" /db_xref="CDD:163713" Site order(63,68,116..117,136..137,152..156,158,161,167..172, 176,179,245,248,251..252,256,259..260,263,286..287,292,294, 320,322..323,325,328,335..336,344,346,349,352..354, 357..358,361..363,365..366,368..371,375,380..381,383,387, 389..391,401..406,472..473,475,477,481) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:163713" Site order(70,109,143,148,156,351,355) /site_type="other" /note="heme binding pocket [chemical binding]" /db_xref="CDD:163713" Site order(146,191,195,198,200,210,232,234,299..302,445, 448..449) /site_type="other" /note="NADPH binding site [chemical binding]" /db_xref="CDD:163713" CDS 1..515 /gene="CTA1" /locus_tag="YDR256C" /coded_by="NM_001180564.1:1..1548" /experiment="EXISTENCE:direct assay:GO:0004096 catalase activity [PMID:9931255]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:14998369]" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:1986244]" /experiment="EXISTENCE:direct assay:GO:0042744 hydrogen peroxide catabolic process [PMID:9931255]" /experiment="EXISTENCE:genetic interaction:GO:0004096 catalase activity [PMID:3897793]" /experiment="EXISTENCE:genetic interaction:GO:0042744 hydrogen peroxide catabolic process [PMID:3897793]" /experiment="EXISTENCE:mutant phenotype:GO:0000302 response to reactive oxygen species [PMID:15893481]" /experiment="EXISTENCE:mutant phenotype:GO:0004096 catalase activity [PMID:3897793]" /experiment="EXISTENCE:mutant phenotype:GO:0042744 hydrogen peroxide catabolic process [PMID:3897793]" /note="Catalase A; breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation" /db_xref="GeneID:851843" /db_xref="SGD:S000002664" ORIGIN 1 msklgqekne vnysdvredr vvtnstgnpi nepfvtqrig ehgplllqdy nlidslahfn 61 renipqrnph ahgsgafgyf evtdditdic gsamfskigk rtkcltrfst vggdkgsadt 121 vrdprgfatk fyteegnldw vynntpvffi rdpskfphfi htqkrnpqtn lrdadmfwdf 181 lttpenqvai hqvmilfsdr gtpanyrsmh gysghtykws nkngdwhyvq vhiktdqgik 241 nltieeatki agsnpdycqq dlfeaiqngn ypswtvyiqt mterdakklp fsvfdltkvw 301 pqgqfplrrv gkivlnenpl nffaqveqaa fapsttvpyq easadpvlqa rlfsyadahr 361 yrlgpnfhqi pvncpyaskf fnpairdgpm nvngnfgsep tylandksyt yiqqdrpiqq 421 hqevwngpai pyhwatspgd vdfvqarnly rvlgkqpgqq knlaynigih vegacpqiqq 481 rvydmfarvd kglseaikkv aeakhasels snskf // LOCUS NP_010543 494 aa linear PLN 30-JUN-2025 DEFINITION ribosomal lysine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010543 VERSION NP_010543.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180565.1 REFERENCE 1 (residues 1 to 494) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 494) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 494) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 494) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12097. Method: conceptual translation. FEATURES Location/Qualifiers source 1..494 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..494 /product="ribosomal lysine N-methyltransferase" /calculated_mol_wt="57158" Region 21..281 /region_name="SET_SETD6" /note="SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; cd19178" /db_xref="CDD:380955" Site order(37..39,187..188,226..231,264,276,278) /site_type="other" /note="SAM binding site" /db_xref="CDD:380955" Site order(38..39,56,185..190,226..230,239,262..265) /site_type="active" /note="putative active site [active]" /db_xref="CDD:380955" CDS 1..494 /gene="RKM4" /locus_tag="YDR257C" /gene_synonym="RMS1; SET7" /coded_by="NM_001180565.1:1..1485" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0016279 protein-lysine N-methyltransferase activity [PMID:18957409]" /experiment="EXISTENCE:genetic interaction:GO:0018026 peptidyl-lysine monomethylation [PMID:18957409]" /experiment="EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:18957409]" /experiment="EXISTENCE:mutant phenotype:GO:0018026 peptidyl-lysine monomethylation [PMID:24517342|PMID:18957409]" /note="Ribosomal lysine methyltransferase; specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein" /db_xref="GeneID:851844" /db_xref="SGD:S000002665" ORIGIN 1 mddfsrdten fvcwlkttae ievspkieik dlccdnqgra vvatqkikkd etlfkiprss 61 vlsvttsqli kdypslkdkf lnetgswegl iicilyemev lqersrwapy fkvwnkpsdm 121 nalifwddne lqllkpslvl erigkkeake mheriiksik qiggefsrva tsfefdnfay 181 iasiilsysf dlemqdssvn eneeeetsee elenerylks mipladmlna dtskcnanlt 241 ydsnclkmva lrdiekneqv yniygehpns ellrrygyve wdgskydfge vlleniveal 301 ketfetntef ldrcidilrn naniqefleg eeivldsydc ynngellpql illvqiltil 361 cqipglckld ikamerqver ivkkclqlie garattncsa twkrcimkrl adypikkcvs 421 iekpskgnsl treelrdvma rrvlkseids lqvceetidk nykvipdekl ltnilkrklt 481 eeekssvkrp cvkk // LOCUS NP_010544 811 aa linear PLN 30-JUN-2025 DEFINITION chaperone ATPase HSP78 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010544 VERSION NP_010544.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180566.3 REFERENCE 1 (residues 1 to 811) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 811) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 811) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 811) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12098. On Jul 30, 2012 this sequence version replaced NP_010544.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..811 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..811 /product="chaperone ATPase HSP78" /calculated_mol_wt="91205" Region 88..794 /region_name="ClpA" /note="ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones]; COG0542" /db_xref="CDD:440308" CDS 1..811 /gene="HSP78" /locus_tag="YDR258C" /coded_by="NM_001180566.3:1..2436" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8413229]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:11734006]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:11734006]" /experiment="EXISTENCE:direct assay:GO:0051787 misfolded protein binding [PMID:7628444]" /experiment="EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:7500331]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:8830768]" /experiment="EXISTENCE:genetic interaction:GO:0050821 protein stabilization [PMID:7628444]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:11734006]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:7628444|PMID:8830768]" /experiment="EXISTENCE:mutant phenotype:GO:0042026 protein refolding [PMID:11734006]" /experiment="EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:16460754]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:16460754]" /note="Oligomeric mitochondrial matrix chaperone; cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; prevents the aggregation of misfolded proteins as well as resolubilize protein aggregates; involved in response to ethanol stress" /db_xref="GeneID:851845" /db_xref="SGD:S000002666" ORIGIN 1 mlrqatkapi qkylqrtqll rrstpriyti vqckrsicsf narprvankl lsdiktnaln 61 evaistcalk ssyglpnfkr tyvqmrmdpn qqpekpaleq fgtnltklar dgkldpvigr 121 deeiaraiqi lsrrtknnpc ligragvgkt alidglaqri vagevpdslk dkdlvaldlg 181 sliagakyrg efeerlkkvl eeidkangkv ivfidevhml lglgktdgsm dasnilkpkl 241 arglrcisat tldefkiiek dpalsrrfqp illnepsvsd tisilrglke ryevhhgvri 301 tdtalvsaav lsnryitdrf lpdkaidlvd eacavlrlqh eskpdeiqkl draimkiqie 361 leslkketdp vsverreale kdlemkndel nrltkiwdae raeiesikna kanleqarie 421 lekcqregdy tkaselrysr ipdlekkval sekskdgdkv nllhdsvtsd diskvvakmt 481 giptetvmkg dkdrllymen slkervvgqd eaiaaisdav rlqragltse krpiasfmfl 541 gptgtgktel tkalaeflfd desnvirfdm sefqekhtvs rligappgyv lsesggqlte 601 avrrkpyavv lfdefekahp dvsklllqvl degkltdslg hhvdfrntii vmtsnigqdi 661 llndtklgdd gkidtatknk vieamkrsyp pefinriddi lvfnrlskkv lrsivdiria 721 eiqdrlaekr mkidltdeak dwltdkgydq lygarplnrl ihrqilnsma tfllkgqirn 781 getvrvvvkd tklvvlpnhe egevveeeae k // LOCUS NP_010545 383 aa linear PLN 30-JUN-2025 DEFINITION Yap6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010545 VERSION NP_010545.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180567.3 REFERENCE 1 (residues 1 to 383) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 383) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 383) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 383) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12099. On Jul 30, 2012 this sequence version replaced NP_010545.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..383 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..383 /product="Yap6p" /calculated_mol_wt="43466" Region <209..>379 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 223..278 /region_name="bZIP_1" /note="bZIP transcription factor; pfam00170" /db_xref="CDD:395118" Site order(223,227..228,230..232,234..235,238..239,241..242) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269836" Region 226..280 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269836" Site order(245..246,249..250,252,253,255..256,259,262..263, 266..267,270,273..274,276..277) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269836" CDS 1..383 /gene="YAP6" /locus_tag="YDR259C" /gene_synonym="HAL7" /coded_by="NM_001180567.3:1..1152" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:18287073]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11179441]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18287073]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:18287073]" /experiment="EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:21552514]" /experiment="EXISTENCE:physical interaction:GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [PMID:21552514]" /note="Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expression of genes involved in carbohydrate metabolism; YAP6 has a paralog, CIN5, that arose from the whole genome duplication" /db_xref="GeneID:851846" /db_xref="SGD:S000002667" ORIGIN 1 mqnpplirpd mynqgsssma tynaseknln ehpspqiaqp stsqklpyri nptttngdtd 61 isvnsnpiqp plpnlmhlsg psdyrsmhqs pihpsyiipp hsnerkqsas ynrpqnahvs 121 iqpsvvfppk sysisyapyq inpplpnglp nqsislnkey iaeeqlstlp srntsvttap 181 psfqnsadta knsadnndnn dnvtkpvpdk dtqlisssgk tlrntrraaq nrtaqkafrq 241 rkekyiknle qkskifddll aennnfksln dslrndnnil iaqheairna itmlrseydv 301 lcnennmlkn ensiiknehn msrnenenlk lenkrfhaey irmiedient krkeqeqrde 361 ieqlkkkirs leeivgrhsd sat // LOCUS NP_010546 170 aa linear PLN 30-JUN-2025 DEFINITION Swm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010546 VERSION NP_010546.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180568.1 REFERENCE 1 (residues 1 to 170) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 170) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 170) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 170) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12100. Method: conceptual translation. FEATURES Location/Qualifiers source 1..170 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..170 /product="Swm1p" /calculated_mol_wt="19225" Region 7..111 /region_name="Apc13p" /note="Apc13p protein; pfam05839" /db_xref="CDD:310437" CDS 1..170 /gene="SWM1" /locus_tag="YDR260C" /gene_synonym="APC13" /coded_by="NM_001180568.1:1..513" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10022899]" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:12574115|PMID:15060174|PMID:12609981]" /experiment="EXISTENCE:mutant phenotype:GO:0030071 regulation of mitotic metaphase/anaphase transition [PMID:12609981]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:10022899]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:15060174]" /experiment="EXISTENCE:mutant phenotype:GO:1904824 anaphase-promoting complex assembly [PMID:15060174]" /note="Subunit of the anaphase-promoting complex (APC); APC is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation" /db_xref="GeneID:851847" /db_xref="SGD:S000002668" ORIGIN 1 mssssyrdsy fqyrhlpaph hilyaewnqd ilalpdevan itmamkdntr tdaeegrapq 61 dgernsnvre saqgkalmts eqnsnrywns fhdeddwnlf ngmelesngv vtfagqafdh 121 slnggtnsrn dganeprket itgsifdrri tqlayarnng whelalpqsr // LOCUS NP_010547 562 aa linear PLN 30-JUN-2025 DEFINITION glucan exo-1,3-beta-glucosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010547 VERSION NP_010547.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180569.1 REFERENCE 1 (residues 1 to 562) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 562) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 562) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 562) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12101. Method: conceptual translation. FEATURES Location/Qualifiers source 1..562 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..562 /product="glucan exo-1,3-beta-glucosidase" /EC_number="3.2.1.58" /calculated_mol_wt="63377" Region 108..459 /region_name="BglC" /note="Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism]; COG2730" /db_xref="CDD:442036" CDS 1..562 /gene="EXG2" /locus_tag="YDR261C" /coded_by="NM_001180569.1:1..1689" /experiment="EXISTENCE:curator inference:GO:0031505 fungal-type cell wall organization [PMID:7875558]" /experiment="EXISTENCE:direct assay:GO:0004338 glucan exo-1,3-beta-glucosidase activity [PMID:7875558]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:7875558]" /note="Exo-1,3-beta-glucanase; involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor" /db_xref="GeneID:851848" /db_xref="SGD:S000002669" ORIGIN 1 mplksfffsa flvlclskft qgvgttekee slsplelnil qnkfasyyan dtitvkgiti 61 ggwlvtepyi tpslyrnats lakqqnsssn isivdeftlc ktlgyntslt lldnhfktwi 121 teddfeqikt ngfnlvripi gywawkqntd knlyidnitf ndpyvsdglq lkylnnalew 181 aqkyelnvwl dlhgapgsqn gfdnsgeril ygdlgwlrln ntkeltlaiw rdmfqtflnk 241 gdkspvvgiq ivneplggki dvsditemyy eafdllkknq nssdnttfvi hdgfqgighw 301 nlelnptyqn vshhyfnltg anyssqdilv dhhhyevftd aqlaetqfar ieniinygds 361 ihkelsfhpa vvgewsgait dcatwlngvg vgarydgsyy nttlfttndk pvgtcisqns 421 ladwtqdyrd rvrqfieaql atysskttgw ifwnwkteda vewdylklke anlfpspfdn 481 ytyfkadgsi eekfssslsa qafprttssv lsstttsrks knaaisnklt tsqllpiknm 541 sltwkasvca laitiaalca sl // LOCUS NP_058147 438 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058147 VERSION NP_058147.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184422.3 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12103. On Jul 30, 2012 this sequence version replaced NP_058147.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..438 /product="gag protein" /calculated_mol_wt="49593" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..438 /locus_tag="YDR261W-A" /coded_by="NM_001184422.3:1..1317" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:851850" /db_xref="SGD:S000007396" ORIGIN 1 mesqqlhqnp hslhgsaaas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqnq hsevpqaktk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvts rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lrpateri // LOCUS NP_058146 1770 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058146 VERSION NP_058146.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184423.4 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12102. On Jul 30, 2012 this sequence version replaced NP_058146.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1770 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="201832" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 574..641 /region_name="gag_pre-integrs" /note="GAG-pre-integrase domain; pfam13976" /db_xref="CDD:372857" Region 660..761 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1285..>1468 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1621..1757 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1625..1628,1662..1664,1667,1700,1727,1754) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1770 /locus_tag="YDR261W-B" /coded_by="join(NM_001184423.4:1..1293, NM_001184423.4:1295..5314)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:851851" /db_xref="SGD:S000007397" ORIGIN 1 mesqqlhqnp hslhgsaaas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqnq hsevpqaktk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvts rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lgqqqkeskp trtidsndel pdhllidsga sqtlvrsahy lhhatpnsei 481 nivdaqkqdi pinaignlhf nfqngtktsi kalhtpniay dllslselan qnitacftrn 541 tlersdgtvl apivkhgdfy wlskkylips hiskltinnv nksksvnkyp yplihrmlgh 601 anfrsiqksl kknavtylke sdiewsnast yqcpdcligk stkhrhikgs rlkyqesyep 661 fqylhtdifg pvhhlpksap syfisftdek trfqwvyplh drreesilnv ftsilafikn 721 qfnarvlviq mdrgseytnk tlhkfftnrg itacytttad srahgvaerl nrtllndcrt 781 llhcsglpnh lwfsavefst iirnslvspk ndksarqhag lagldittil pfgqpvivnn 841 hnpdskihpr gipgyalhps rnsygyiiyl pslkktvdtt nyvilqdnqs kldqfnydtl 901 tfdddlnrlt ahnqsfieqn eteqsydqnt esdhdyqsei einsdplvnd fssqslnplq 961 ldkepvqkvr apkevdadis eynilpstir srtphiinke stemggties dttsprhsst 1021 ftarnqkrpg spndmidlts qdrvnyglen ikttrlggte epyiqrnsdt nikyrttnst 1081 psiddrssns esttpiisie tkavcdntps idtdppeyrs sdhatpnimp dkssknvtad 1141 silddlplpd ltnksptdts dvskdiphih srqtnsslgg mddsnvlttt kskkrsledn 1201 eteievsrdt wnnknmrsle pprskkrinl iaaikgvksi kpvrttlryd eaitynkdnk 1261 ekdryveayh keisqllkmn twdtnkyydr ndidpkkvin smfifnkkrd gthkarfvar 1321 gdiqhpdtyd sdmqsntvhh yalmtslsia ldndyyitql dissaylyad ikeelyirpp 1381 phlglndkll rlrkslyglk qsganwyeti ksylinccdm qevrgwscvf knsqvticlf 1441 vddmilfskd lnankkiitt lkkqydtkii nlgegdneiq ydilgleiky qrskymklgm 1501 ekslteklpk lnvplnpkgk klrapgqpgh yidqdeleid edeykekvhe mqkliglasy 1561 vgykfrfdll yyintlaqhi lfpsrqvldm tyeliqfiwn trdkqliwhk skpvkptnkl 1621 vvisdasygn qpyyksqign iyllngkvig gkstkasltc tstteaeiha vseaipllnn 1681 lshlvqelnk kpiikglltd srstisiiks tneekfrnrf fgtkamrlrd evsgnnlyvy 1741 yietkmniad vmtkplpikt fklltnkwih // LOCUS NP_058148 1604 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058148 VERSION NP_058148.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184421.2 REFERENCE 1 (residues 1 to 1604) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1604) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1604) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1604) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12104. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1604 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1604 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="181530" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" CDS 1..1604 /locus_tag="YDR261C-D" /coded_by="join(NM_001184421.2:1..1305, NM_001184421.2:1307..4816)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; Gag processing produces capsid proteins, Pol is cleaved to produce protease, reverse transcriptase and integrase activities; in YDRCTy1-3 TYB is mutant and probably non-functional" /db_xref="GeneID:851852" /db_xref="SGD:S000007395" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp nsapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd eyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli qqcgmeevrg wscvfknsqv ticlfvddmv lfsknlnsnk 1441 riieklkmqy dtkiinlges deeiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhkhktss dkni // LOCUS NP_058149 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058149 VERSION NP_058149.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184420.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12105. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..440 /product="gag protein" /calculated_mol_wt="48878" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YDR261C-C" /coded_by="NM_001184420.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; Gag processing produces capsid proteins; in YDRCTy1-3 TYB is mutant and probably non-functional" /db_xref="GeneID:851853" /db_xref="SGD:S000007394" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_010548 272 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR262W [Saccharomyces cerevisiae S288C]. ACCESSION NP_010548 VERSION NP_010548.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180570.3 REFERENCE 1 (residues 1 to 272) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 272) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 272) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 272) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12106. On Jul 30, 2012 this sequence version replaced NP_010548.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..272 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..272 /product="uncharacterized protein" /calculated_mol_wt="30503" CDS 1..272 /locus_tag="YDR262W" /coded_by="NM_001180570.3:1..819" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment" /db_xref="GeneID:851855" /db_xref="SGD:S000002670" ORIGIN 1 mifnlpvsvl lyfsliwame psfvrgknvv nlitfkdsng klhkrlapee ipprlhnsqv 61 nsyplgykgm rdfsrpavnl ddilgtqqrk qqeflaelsp lslesklslv nevqifasyv 121 rndvetynkv sdpnedliii aptnravsql tlkpwqfpnn idklesdgat ekeldtaiqe 181 niskfvrshi vvynddknsy kkvspgctll qsidfteskk sdsetggdil lkkegevyyv 241 assrdekfha vesiengsng vilmvdftlv gp // LOCUS NP_010549 430 aa linear PLN 30-JUN-2025 DEFINITION exodeoxyribonuclease DIN7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010549 VERSION NP_010549.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180571.3 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12107. On Jul 30, 2012 this sequence version replaced NP_010549.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..430 /product="exodeoxyribonuclease DIN7" /calculated_mol_wt="48903" Region 1..202 /region_name="PIN_EXO1" /note="FEN-like PIN domains of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs; cd09857" /db_xref="CDD:350207" Site order(2..4,7..8,30,32..33,36..37,40..41,54,58,78,85,89,92, 95..96,117,120..121,150,152,170..173,185) /site_type="active" /db_xref="CDD:350207" Site order(84..109,111..127) /site_type="other" /note="helical arch" /db_xref="CDD:350207" Region 215..287 /region_name="H3TH_StructSpec-5'-nucleases" /note="H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; cl22433" /db_xref="CDD:473957" Site order(224..225,227,234..236,241) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:188616" Site 227 /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:188616" CDS 1..430 /gene="DIN7" /locus_tag="YDR263C" /gene_synonym="DIN3" /coded_by="NM_001180571.3:1..1293" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10628970]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:9079876]" /experiment="EXISTENCE:mutant phenotype:GO:0035312 5'-3' DNA exonuclease activity [PMID:23598996]" /note="Mitochondrial nuclease functioning in DNA repair and replication; modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination; DIN7 has a paralog, EXO1, that arose from the whole genome duplication" /db_xref="GeneID:851856" /db_xref="SGD:S000002671" ORIGIN 1 mgipgllpql kriqkqvslk kymyqtlaid gyawlhrasc acafelvmnk ptnkylqffi 61 krlqllkrlk ikpyivfdgd slfvknhtet rrrkkrlene miakklwsag nrynameyfq 121 ksvditpema kciidycklh sipyivapfe adpqmvylek mgliqgiise dsdllvfgck 181 tlitklndqg kaleiskddf salpenfplg elseqqfrnl vclagcdyts giwkvgvvta 241 mkivkrysem kdiliqiert eklcfskafk qqvefanyaf qyqrvfcpls nqittlnnip 301 kavtnshaei ikimkcigsv vergsgvrkd vintknidhk vhemiakgel hpvdmaskli 361 nrerklkark lfkvgllgge snsfnkkveq plvdtqdvls erensldnkn assiymtspa 421 aisgtvpsif // LOCUS NP_010550 764 aa linear PLN 30-JUN-2025 DEFINITION palmitoyltransferase AKR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010550 VERSION NP_010550.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180572.1 REFERENCE 1 (residues 1 to 764) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 764) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 764) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 764) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12108. Method: conceptual translation. FEATURES Location/Qualifiers source 1..764 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..764 /product="palmitoyltransferase AKR1" /EC_number="2.3.1.225" /calculated_mol_wt="85709" Region 31..300 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 75..101 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(78..79,82..84,86..87,91,101,103,110,114..115, 118..120,122..123,127,130,140,142,144,148..149,152..154, 156..157,161,164,173) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 103..140 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 142..173 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 213..244 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 246..271 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 363..725 /region_name="COG5273" /note="Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]" /db_xref="CDD:227598" CDS 1..764 /gene="AKR1" /locus_tag="YDR264C" /coded_by="NM_001180572.1:1..2295" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:16647879]" /experiment="EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:12370247]" /experiment="EXISTENCE:direct assay:GO:0018345 protein palmitoylation [PMID:12370247|PMID:16227572]" /experiment="EXISTENCE:genetic interaction:GO:0090029 negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8524293]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:16227572]" /experiment="EXISTENCE:mutant phenotype:GO:0018345 protein palmitoylation [PMID:16751107|PMID:16227572]" /experiment="EXISTENCE:mutant phenotype:GO:0030100 regulation of endocytosis [PMID:10866691]" /experiment="EXISTENCE:mutant phenotype:GO:0090029 negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8649369]" /experiment="EXISTENCE:physical interaction:GO:0031683 G-protein beta/gamma-subunit complex binding [PMID:8649369]" /note="Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication; any of several human homologs encoding DHHC-type zinc fingers (ZDHHC) can complement temperature sensitivity of yeast akr1 null mutant" /db_xref="GeneID:851857" /db_xref="SGD:S000002672" ORIGIN 1 mvnelenvpr astltneeqt vdpsnndsqe dislgdsnei tslaslkair sgneeesgne 61 qvnhndeaee dplltryhta cqrgdlatvk emihgkllev nndgdstehi tglhwasinn 121 rlsvvdflvs qgadvnarag alhatplhwa arygyvyivd fllkhgadpt mtddqgfnll 181 hlsvnssnim lvlyvlfnvv skglldidcr dpkgrtsllw aayqgdsltv aellkfgasi 241 kiadtegftp lhwgtvkgqp hvlkyliqdg adffqktdtg kdcfaiaqem ntvyslreal 301 thsgfdyhgy pikkwfkksq haklvtfitp flflgiafal fshinplfvi ivlfllaiat 361 nkglnkfvlp sygrmgvhnv tllrspllsg vffgtllwvt ivwffkvmpr tfsdeqytni 421 lmlvilvsvf ylfgqlvimd pgclpeetdh envrqtisnl leigkfdtkn fcietwirkp 481 lrskfsplnn avvarfdhyc pwifndvglk nhkafiffit lmesgiftfl alcleyfdel 541 edahedtsqk ngkcfilgas dlcsgliydr fvflillwal lqsiwvasli fvqafqickg 601 mtntefnvlm kesksigpdg lsfnenfntt pegfapsidp geesndtvla pvpgstirkp 661 rtcfgvcyav tgmdqwlavi ketigikdst ghnvysitsr iptnygwkrn vkdfwltsdi 721 naplwrrily ppsgskalln gievdyfkly klpnkdveqg ndmv // LOCUS NP_010551 337 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein ligase peroxin 10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010551 VERSION NP_010551.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180573.1 REFERENCE 1 (residues 1 to 337) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 337) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 337) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 337) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12109. Method: conceptual translation. FEATURES Location/Qualifiers source 1..337 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..337 /product="ubiquitin-protein ligase peroxin 10" /EC_number="2.3.2.27" /calculated_mol_wt="38968" Region 5..337 /region_name="PEX10" /note="RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]; COG5574" /db_xref="CDD:227861" CDS 1..337 /gene="PEX10" /locus_tag="YDR265W" /gene_synonym="PAS4" /coded_by="NM_001180573.1:1..1014" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:35768507|PMID:27678487|PMID:12876220]" /experiment="EXISTENCE:direct assay:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:35768507|PMID:19687296|PMID:18644345|PMID:22471590]" /experiment="EXISTENCE:direct assay:GO:1902495 transmembrane transporter complex [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:35768507|PMID:22375831]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:15536088]" /note="Peroxisomal membrane E3 ubiquitin ligase; required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders" /db_xref="GeneID:851858" /db_xref="SGD:S000002673" ORIGIN 1 mkndnklqke almrlsqlrf pfadapsivq ahqkdeqiqg llimkvtelc kliksqlfvn 61 sypkelsifa kllyllfttg rrgrtlgeey vdltytnrkg trlagrlkmi vfafayplcp 121 yfitklykki mknnkeskie dtesvaafck glldfildvh mtlfyfkgaf ysiskrifgm 181 ryvfkhilsk neanfreegs qkykvlgyil laqnvmkwyp vltstlgswi ygrkrtndsi 241 trssvglqer sehesiegip kesqlthinl sdknqlpfip easrkcilcl mnmsdpscap 301 cghlfcwscl mswckerpec plcrqhcqpq eilvlrq // LOCUS NP_010552 639 aa linear PLN 30-JUN-2025 DEFINITION E3 ubiquitin-protein ligase HEL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010552 VERSION NP_010552.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180574.3 REFERENCE 1 (residues 1 to 639) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 639) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 639) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 639) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12110. On Jul 30, 2012 this sequence version replaced NP_010552.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..639 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..639 /product="E3 ubiquitin-protein ligase HEL2" /EC_number="2.3.2.27" /calculated_mol_wt="72625" Region 1..507 /region_name="COG5236" /note="Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]" /db_xref="CDD:227561" CDS 1..639 /gene="HEL2" /locus_tag="YDR266C" /gene_synonym="RQT1" /coded_by="NM_001180574.3:1..1920" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:8947054]" /experiment="EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:30609991|PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:33338396|PMID:32615089|PMID:28757607|PMID:30609991|P MID:30893611]" /experiment="EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0055106 ubiquitin-protein transferase regulator activity [PMID:32615089]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:30609991|PMID:28757607|PMID:30893611|PMID:22570702]" /experiment="EXISTENCE:direct assay:GO:0070534 protein K63-linked ubiquitination [PMID:28757607|PMID:30609991|PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0070651 nonfunctional rRNA decay [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:30609991|PMID:31219035]" /experiment="EXISTENCE:direct assay:GO:0072344 rescue of stalled ribosome [PMID:33338396|PMID:32615089|PMID:30609991|PMID:36627279|P MID:30893611]" /experiment="EXISTENCE:direct assay:GO:0140469 GCN2-mediated signaling [PMID:8798780]" /experiment="EXISTENCE:direct assay:GO:0170011 stalled ribosome sensor activity [PMID:32615089|PMID:33338396]" /experiment="EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:31532761]" /experiment="EXISTENCE:mutant phenotype:GO:0036205 histone catabolic process [PMID:22570702]" /experiment="EXISTENCE:mutant phenotype:GO:0061157 mRNA destabilization [PMID:31532761]" /note="RING finger ubiquitin ligase (E3); subunit of ribosome-associated quality control trigger complex (RQT); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; required to trigger ribosome-associated quality control (RQC) and canonical no-go decay; ubiquitinates Rps20 and Rps3; binds to ribosomal RNA, mRNA and tRNA" /db_xref="GeneID:851859" /db_xref="SGD:S000002674" ORIGIN 1 msesvkenvt ptrnfrrtqg pqnntkphnd rknfrrkqkk nnlsaepnlt tssaddtdee 61 nelcvicark ltyvsltpch hktchicgfr qralynkksc licrteneev mftdridgdi 121 sdkynfcekn ekyginftse evatetlnll kffcplskde qvcdfgsfkk ynehlksehn 181 rmiclicath khafpcelei ftqnqlrnhq tkgnsegfkg hpmcafcsgk rfysddelyi 241 hmrnqhekch icdkmnpasp qyfkdynqlf dhfkhshyvc tvqtcldnkf vvfkdelelq 301 ahilqehgni lkgkpkffqs elstfisaps rvirerddyd lpsisslpgs ssgsrtdvrs 361 asspeesrlr laerakyyle nskedfnkfs synedyskgr lsaekllesy kllftkpnad 421 vyllihnlae tfpknsskyn nlnaiyeqre qtlarqtslp slssdsslsm sigrghwggt 481 ndggsagaal gvrniknlpt lkspsasydp fattvkkntl rpvqnikrtt pqsvsyrtst 541 ntvafsptyl eskkgsssts lnnskdklks lnlpqlpppk pkvqipglnr pqiadpkqwg 601 kksstqdtnv hdnlrelntt sggnkkkgkq kqllfhigv // LOCUS NP_010553 330 aa linear PLN 30-JUN-2025 DEFINITION iron-sulfur cluster assembly protein CIA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010553 VERSION NP_010553.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180575.3 REFERENCE 1 (residues 1 to 330) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 330) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 330) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 330) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12111. On Jul 30, 2012 this sequence version replaced NP_010553.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..330 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..330 /product="iron-sulfur cluster assembly protein CIA1" /calculated_mol_wt="37144" Region 6..325 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(13,29,33,39..40,56..57,75,79,85..86,105..106,123,128, 134..135,152,169,174,180..181,195..196,216,220,226,235, 248..249,265,270,276..277,314,318,324..325) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 17..54 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 63..105 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 111..151 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 156..194 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 201..246 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 253..289 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 298..326 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..330 /gene="CIA1" /locus_tag="YDR267C" /coded_by="NM_001180575.3:1..993" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:16314508]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16314508]" /experiment="EXISTENCE:direct assay:GO:0097361 cytosolic [4Fe-4S] assembly targeting complex [PMID:22678362]" /experiment="EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:17937914]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:17937914|PMID:16314508]" /note="Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at late step of Fe-S cluster assembly; forms CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of cytosolic and nuclear proteins involved in methionine biosynthesis, DNA replication and repair, transcription and telomere maintenance; contains WD40 repeats; human homolog CIAO1 complements the yeast cia1 null mutant" /db_xref="GeneID:851860" /db_xref="SGD:S000002675" ORIGIN 1 masinliksl klykekiwsf dfsqgilatg stdrkiklvs vkyddftlid vldetahkka 61 irsvawrpht sllaagsfds tvsiwakees adrtfemdll aiieghenev kgvawsndgy 121 ylatcsrdks vwiwetdesg eeyecisvlq ehsqdvkhvi whpseallas ssyddtvriw 181 kdydddwecv avlnghegtv wssdfdkteg vfrlcsgsdd stvrvwkymg ddeddqqewv 241 ceailpdvhk rqvynvawgf ngliasvgad gvlavyeevd gewkvfakra lchgvyeinv 301 vkwlelngkt ilatggddgi vnfwslekaa // LOCUS NP_010554 379 aa linear PLN 30-JUN-2025 DEFINITION tryptophan--tRNA ligase MSW1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010554 VERSION NP_010554.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180576.1 REFERENCE 1 (residues 1 to 379) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 379) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 379) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 379) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12112. Method: conceptual translation. FEATURES Location/Qualifiers source 1..379 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..379 /product="tryptophan--tRNA ligase MSW1" /EC_number="6.1.1.2" /calculated_mol_wt="42884" Region 33..379 /region_name="trpS" /note="tryptophanyl-tRNA synthetase; TIGR00233" /db_xref="CDD:272975" CDS 1..379 /gene="MSW1" /locus_tag="YDR268W" /coded_by="NM_001180576.1:1..1140" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0004830 tryptophan-tRNA ligase activity [PMID:2999114]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:2999114]" /experiment="EXISTENCE:mutant phenotype:GO:0070183 mitochondrial tryptophanyl-tRNA aminoacylation [PMID:2999114]" /note="Mitochondrial tryptophanyl-tRNA synthetase" /db_xref="GeneID:851861" /db_xref="SGD:S000002676" ORIGIN 1 msnkqavlkl iskrwistvq radfklnsea lhsnatvfsm iqptgcfhlg nylgatrvwt 61 dlcelkqpgq elifgvadlh aitvpkpdge mfrkfrheav asilavgvdp ekasviyqsa 121 ipqhselhwl lstlasmgll nrmtqwksks nikqstngdy lvndsdvgkv rlglfsypvl 181 qaadillyks thvpvgddqs qhleltrhla ekfnkmykkn ffpkpvtmla qtkkvlslst 241 pekkmsksdp nhdsviflnd epkaiqkkir kaltdsisdr fyydpverpg vsnlinivsg 301 iqrksiedvv edvsrfnnyr dfkdyvsevi ieelkgprte fekyinepty lhsvvesgmr 361 karekaaknl adihkimgf // LOCUS NP_010556 1004 aa linear PLN 30-JUN-2025 DEFINITION Cu(2+)-transporting P-type ATPase CCC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010556 VERSION NP_010556.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180578.1 REFERENCE 1 (residues 1 to 1004) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1004) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1004) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1004) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1004) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1004) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1004) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1004) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1004) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12113. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1004 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1004 /product="Cu(2+)-transporting P-type ATPase CCC2" /EC_number="7.2.2.8" /calculated_mol_wt="109698" Region 6..67 /region_name="HMA" /note="Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; cd00371" /db_xref="CDD:238219" Site order(11..13,16) /site_type="metal-binding" /note="metal-binding site [ion binding]" /db_xref="CDD:238219" Region 84..144 /region_name="HMA" /note="Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; cd00371" /db_xref="CDD:238219" Site order(89..91,94) /site_type="metal-binding" /note="metal-binding site [ion binding]" /db_xref="CDD:238219" Region 259..938 /region_name="P-type_ATPase_Cu-like" /note="P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; cd02094" /db_xref="CDD:319783" Site order(583,585,908) /site_type="other" /note="putative Cu binding site [ion binding]" /db_xref="CDD:319783" Site order(627..629,699,719..721,747,787..789,811,814,817,838, 841) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:319783" CDS 1..1004 /gene="CCC2" /locus_tag="YDR270W" /coded_by="NM_001180578.1:1..3015" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:17961510]" /experiment="EXISTENCE:direct assay:GO:0012510 trans-Golgi network transport vesicle membrane [PMID:9325307]" /experiment="EXISTENCE:direct assay:GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity [PMID:15078884]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:7708696]" /experiment="EXISTENCE:mutant phenotype:GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity [PMID:7708696]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:7708696]" /experiment="EXISTENCE:mutant phenotype:GO:0060003 copper ion export [PMID:7708696]" /note="Cu(+2)-transporting P-type ATPase; required for export of copper from cytosol into extracytosolic compartment; targeted to vacuole via AP-3 pathway; similar to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism; human homologs ATP7A and ATP7B both complement yeast null mutant" /db_xref="GeneID:851862" /db_xref="SGD:S000002678" ORIGIN 1 mrevilavhg mtcsactnti ntqlralkgv tkcdislvtn ecqvtydnev tadsikeiie 61 dcgfdceilr dseitaistk egllsvqgmt cgscvstvtk qvegiegves vvvslvteec 121 hviyepsktt letaremied cgfdsniimd gngnadmtek tvilkvtkaf edesplilss 181 vserfqflld lgvksieisd dmhtltikyc cnelgirdll rhlertgykf tvfsnldntt 241 qlrllskede irfwkknsik stllaiicml lymivpmmwp tivqdrifpy ketsfvrglf 301 yrdilgvila syiqfsvgfy fykaawaslk hgsgtmdtlv cvsttcaytf svfslvhnmf 361 hpsstgklpr ivfdtsimii syisigkyle tlaksqtsta lskliqltps vcsiisdver 421 netkeipiel lqvndiveik pgmkipadgi itrgeseide slmtgesilv pkktgfpvia 481 gsvngpghfy frtttvgeet klaniikvmk eaqlskapiq gyadylasif vpgililavl 541 tffiwcfiln isanppvaft antkadnffi clqtatsvvi vacpcalgla tptaimvgtg 601 vgaqngvlik ggevlekfns ittfvfdktg tlttgfmvvk kflkdsnwvg nvdedevlac 661 ikatesisdh pvskaiiryc dglncnkaln avvleseyvl gkgivskcqv ngntydicig 721 nealiledal kksgfinsnv dqgntvsyvs vnghvfglfe indevkhdsy atvqylqrng 781 yetymitgdn nsaakrvare vgisfenvys dvsptgkcdl vkkiqdkegn nkvavvgdgi 841 ndapalalsd lgiaistgte iaieaadivi lcgndlntns lrglanaidi slktfkrikl 901 nlfwalcyni fmipiamgvl ipwgitlppm laglamafss vsvvlsslml kkwtppdies 961 hgisdfkskf signfwsrlf straiageqd iesqaglmsn eevl // LOCUS NP_010558 274 aa linear PLN 30-JUN-2025 DEFINITION hydroxyacylglutathione hydrolase GLO2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010558 VERSION NP_010558.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180580.3 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12114. On Jul 30, 2012 this sequence version replaced NP_010558.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..274 /product="hydroxyacylglutathione hydrolase GLO2" /EC_number="3.1.2.6" /calculated_mol_wt="31196" Region 16..188 /region_name="hydroxyacylglutathione_hydrolase_MBL-fold" /note="hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain; cd07723" /db_xref="CDD:293809" Site order(59,61,63..64,121,144,147,151,153,188) /site_type="active" /db_xref="CDD:293809" Region 189..274 /region_name="HAGH_C" /note="Hydroxyacylglutathione hydrolase C-terminus; pfam16123" /db_xref="CDD:465030" CDS 1..274 /gene="GLO2" /locus_tag="YDR272W" /coded_by="NM_001180580.3:1..825" /experiment="EXISTENCE:direct assay:GO:0004416 hydroxyacylglutathione hydrolase activity [PMID:9261170]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9261170]" /experiment="EXISTENCE:direct assay:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:9261170]" /experiment="EXISTENCE:genetic interaction:GO:0004416 hydroxyacylglutathione hydrolase activity [PMID:9261170]" /experiment="EXISTENCE:genetic interaction:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:9261170]" /experiment="EXISTENCE:mutant phenotype:GO:0004416 hydroxyacylglutathione hydrolase activity [PMID:9261170]" /experiment="EXISTENCE:mutant phenotype:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:9261170]" /note="Cytoplasmic glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO2 has a paralog, GLO4, that arose from the whole genome duplication" /db_xref="GeneID:851865" /db_xref="SGD:S000002680" ORIGIN 1 mqvksikmrw esggvnycyl lsdsknkksw lidpaeppev lpeltedeki sveaivnthh 61 hydhadgnad ilkylkeknp tskveviggs kdcpkvtiip enlkklhlgd leitcirtpc 121 htrdsicyyv kdpttderci ftgdtlftag cgrffegtge emdialnnsi letvgrqnws 181 ktrvypghey tsdnvkfvrk iypqvgenka ldeleqfcsk hevtagrftl kdevefnpfm 241 rledpkvqka agdtnnswdr aqimdklram knrm // LOCUS NP_010559 365 aa linear PLN 30-JUN-2025 DEFINITION Don1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010559 VERSION NP_010559.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180581.3 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12115. On Jul 30, 2012 this sequence version replaced NP_010559.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..365 /product="Don1p" /calculated_mol_wt="40031" Region 82..126 /region_name="CUE_Cue5p_like" /note="CUE domain found in yeast ubiquitin-binding protein CUE5 (Cue5p), donuts protein 1 (DON1p) and similar proteins; cd14372" /db_xref="CDD:270555" CDS 1..365 /gene="DON1" /locus_tag="YDR273W" /coded_by="NM_001180581.3:1..1098" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:11973299|PMID:11742972]" /experiment="EXISTENCE:direct assay:GO:0070056 prospore membrane leading edge [PMID:10899120]" /experiment="EXISTENCE:physical interaction:GO:0030476 ascospore wall assembly [PMID:11973299]" /note="Meiosis-specific component of the spindle pole body; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane (PSM) during meiosis II; required for PSM growth and closure; DON1 has a paralog, CUE5, that arose from the whole genome" /db_xref="GeneID:851866" /db_xref="SGD:S000002681" ORIGIN 1 mgkknrkgke nnaaktsflk venikntnsg lelpsqdytn veekesspkt dfplitkehv 61 ntktdsnild yptigdlvss veklcvlkel kiafpevddt likailiasq gvlepafnsl 121 lyysspeent dfalpmkpis vedyskinvs eilqreifdd iedefsgqgi ngsmviskie 181 selsslaehi gnistpgsnr evaestrnva vaeghntils nedsilkgke kgkeeekekg 241 eekgvnslkg aavkvvaksl knnripvtvk rnepsnnlfd vlncdeseee eeqdvetnts 301 nqerknqggn tevpeaqrds adrlpakddg gyksafgtds cglfaadakd ekkqvhpsrq 361 elsft // LOCUS NP_001335760 123 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR274C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335760 VERSION NP_001335760.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348815.1 REFERENCE 1 (residues 1 to 123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 123) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80280. Method: conceptual translation. FEATURES Location/Qualifiers source 1..123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..123 /product="uncharacterized protein" /calculated_mol_wt="13796" CDS 1..123 /locus_tag="YDR274C" /coded_by="NM_001348815.1:1..372" /note="hypothetical protein; conserved among S. cerevisiae strains; YDR274C is not an essential gene" /db_xref="GeneID:851867" /db_xref="SGD:S000002682" ORIGIN 1 mfscllhssr ptdsyctlaa plsqtartrt mtfhaatakr ktehsgikes nlhlsrvlls 61 sfcrakgrfv sfficypfpf gltrfprvlw sigldkslft rvhfspsffs llaplqfsgi 121 vrs // LOCUS NP_010561 235 aa linear PLN 30-JUN-2025 DEFINITION triglyceride-associated lipolysis regulator TLD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010561 VERSION NP_010561.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180583.1 REFERENCE 1 (residues 1 to 235) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 235) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 235) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12116. Method: conceptual translation. FEATURES Location/Qualifiers source 1..235 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..235 /product="triglyceride-associated lipolysis regulator TLD1" /calculated_mol_wt="26451" CDS 1..235 /gene="TLD1" /locus_tag="YDR275W" /gene_synonym="BSC2" /coded_by="NM_001180583.1:1..708" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:37889293|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016042 lipid catabolic process [PMID:37889293]" /note="Protein that regulates lipolysis; inhibits oxidative damage induced by amphotericin B; overexpression increases flocculation, biofilm formation, invasive and pseudohyphal growth; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; null mutant displays increased translation rate and increased readthrough of premature stop codons; TLD1 has a paralog, IRC23, that arose from the whole genome duplication" /db_xref="GeneID:851868" /db_xref="SGD:S000002683" ORIGIN 1 mfffpklrkl igstvidhdt knssgkeeim snsrlalvii nhafdkvlsl twhcgilsei 61 rsglmlmfgi fqlmcslgvi vlllpiiild aidlflymcr lldygcklfh ynrsslpvad 121 gkektsgpis gkeeividee iinmlnesse slinhttagl eydissgsvn ksrrlnstst 181 vtfvkqnklv nerredayye eedddflsnp nydkisliek sftsrfevac eqkaa // LOCUS NP_010562 55 aa linear PLN 30-JUN-2025 DEFINITION Pmp3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010562 VERSION NP_010562.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180584.1 REFERENCE 1 (residues 1 to 55) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 55) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 55) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 55) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12117. Method: conceptual translation. FEATURES Location/Qualifiers source 1..55 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..55 /product="Pmp3p" /calculated_mol_wt="6007" Region 5..53 /region_name="Pmp3" /note="Proteolipid membrane potential modulator; pfam01679" /db_xref="CDD:460290" CDS 1..55 /gene="PMP3" /locus_tag="YDR276C" /gene_synonym="SNA1" /coded_by="NM_001180584.1:1..168" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10835350]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:26303201]" /experiment="EXISTENCE:direct assay:GO:0046625 sphingolipid binding [PMID:26303201]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:26303201]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:26303201]" /experiment="EXISTENCE:mutant phenotype:GO:0006812 monoatomic cation transport [PMID:10835350]" /experiment="EXISTENCE:mutant phenotype:GO:0042391 regulation of membrane potential [PMID:10835350]" /note="Small plasma membrane protein; confers resistance to amphotericin B and is a potential target of this common antifungal drug; related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature; not essential for viability; deletion causes hyperpolarization of the plasma membrane potential" /db_xref="GeneID:851869" /db_xref="SGD:S000002684" ORIGIN 1 mdsakiinii lslflppvav flargwgtdc ivdiiltila wfpgmlyaly ivlqd // LOCUS NP_010563 433 aa linear PLN 30-JUN-2025 DEFINITION Mth1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010563 VERSION NP_010563.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180585.3 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12118. On Jul 30, 2012 this sequence version replaced NP_010563.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..433 /product="Mth1p" /calculated_mol_wt="48929" Region 125..333 /region_name="STD1" /note="STD1/MTH1; pfam17235" /db_xref="CDD:435802" CDS 1..433 /gene="MTH1" /locus_tag="YDR277C" /gene_synonym="BPC1; DGT1; HTR1" /coded_by="NM_001180585.3:1..1302" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:10629208]" /experiment="EXISTENCE:mutant phenotype:GO:1904659 D-glucose transmembrane transport [PMID:10629208]" /note="Negative regulator of the glucose-sensing signal transduction pathway; required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation; MTH1 has a paralog, STD1, that arose from the whole genome duplication" /db_xref="GeneID:851870" /db_xref="SGD:S000002685" ORIGIN 1 mfvspppats knqvlqrrpl estnsnhgfa sslqaipent msgsdnasfq slplsmsssq 61 sttssrrenf vnappeytdr ardeikkrll asspsrrshh sssmhsasrr ssvaesgsll 121 sdnassyqss ifsapstvht qltndssfse fpnhklitrv sldealpktf ydmyspdill 181 adpsnilcng rpkftkrell dwdlndirsl liveklrpew gnqlpevitv gdnmpqfrlq 241 llplyssdet iiatlvhsdl ymeanldyef kltsakytva tarkrhehit grneavmnls 301 kpewrniien yllniaveaq crfdfkqrcs eykkwklqqs nlkrpdmppp siiprknste 361 tksllkkall kniqlknpnn nldelmmrss aatnqqgknk vslskeekat iwsqcqaqvy 421 qrlgldwqpd svs // LOCUS NP_010565 350 aa linear PLN 30-JUN-2025 DEFINITION Rnh202p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010565 VERSION NP_010565.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180587.3 REFERENCE 1 (residues 1 to 350) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 350) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 350) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 350) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12119. On Jul 30, 2012 this sequence version replaced NP_010565.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..350 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..350 /product="Rnh202p" /calculated_mol_wt="39353" Region 12..348 /region_name="RNase_H2-B" /note="Ribonuclease H2-B is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids; cd09270" /db_xref="CDD:187751" Site order(14..16,29,55,87..91) /site_type="other" /note="heterotrimeric interface" /db_xref="CDD:187751" CDS 1..350 /gene="RNH202" /locus_tag="YDR279W" /coded_by="NM_001180587.3:1..1053" /experiment="EXISTENCE:direct assay:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006401 RNA catabolic process [PMID:14734815]" /experiment="EXISTENCE:direct assay:GO:0032299 ribonuclease H2 complex [PMID:14734815]" /experiment="EXISTENCE:genetic interaction:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]" /note="Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS2 that causes Aicardi-Goutieres syndrome" /db_xref="GeneID:851873" /db_xref="SGD:S000002687" ORIGIN 1 mtvsniggee rliilpddye tsktintftl pppsnitskp rielfening klyeirsfqf 61 gkgpsyshee dlandkyhyt kenhpikstf ivntsdptdg yvfnsskihf cslydiafsl 121 igfyyrnsvs adeqdysnss dtgenqksns ktnekfltvr dyhdfltdnh dknwenisls 181 rlksglakvs etieeagdvy ykitsamitq fllgkvskiv enfppsiptl knapteikqc 241 ykvvmatnll vslipraayh nlltfsptmd sgclnpdika sfielenyet tnelqnaere 301 llmksamnvg lnsngrvslp vkkvtkkivq nkkpkvaigk gaidgffkrk // LOCUS NP_010566 305 aa linear PLN 30-JUN-2025 DEFINITION exosome non-catalytic core subunit RRP45 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010566 VERSION NP_010566.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180588.1 REFERENCE 1 (residues 1 to 305) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 305) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 305) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 305) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12120. Method: conceptual translation. FEATURES Location/Qualifiers source 1..305 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..305 /product="exosome non-catalytic core subunit RRP45" /calculated_mol_wt="33831" Region 7..278 /region_name="RNase_PH_RRP45" /note="RRP45 subunit of eukaryotic exosome; cd11368" /db_xref="CDD:206773" Site order(8..10,13..14,18,21,23) /site_type="other" /note="Rrp40 interface [polypeptide binding]" /db_xref="CDD:206773" Site order(42,44,59,61..63,78,80,85,103,106,110,132,137,142, 160..162,192,245..256,261,265) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:206773" CDS 1..305 /gene="RRP45" /locus_tag="YDR280W" /coded_by="NM_001180588.1:1..918" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:19046973|PMID:10465791]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16541108]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:17643380|PMID:15828860]" /experiment="EXISTENCE:genetic interaction:GO:0034473 U1 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:genetic interaction:GO:0034476 U5 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10465791|PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034473 U1 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034476 U5 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:10465791]" /note="Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; protein abundance increases in response to DNA replication stress; has similarity to E. coli RNase PH; human ortholog hRrp45p (PM/SCL-75, EXOSC9) complements the yeast null mutant; mutations in hRrp45p are implicated in pontocerebellar hypoplasia type 1D" /db_xref="GeneID:851874" /db_xref="SGD:S000002688" ORIGIN 1 makdieisas eskfilealr qnyrldgrsf dqfrdveitf gkefgdvsvk mgntkvhcri 61 scqiaqpyed rpfeglfvis teispmagsq fengnitged evlcsriiek svrrsgaldv 121 eglcivagsk cwavradvhf ldcdggfida sciavmaglm hfkkpditvh geqiivhpvn 181 erepvplgil hipicvtfsf fnpqdteeni kgetnseisi idatlkeell rdgvltvtln 241 knrevvqvsk agglpmdalt lmkccheays iiekitdqil qllkedsekr nkyaamltse 301 narei // LOCUS NP_010567 104 aa linear PLN 30-JUN-2025 DEFINITION Phm6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010567 VERSION NP_010567.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180589.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12121. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..104 /product="Phm6p" /calculated_mol_wt="11756" CDS 1..104 /gene="PHM6" /locus_tag="YDR281C" /coded_by="NM_001180589.1:1..315" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006817 phosphate ion transport [PMID:36592238]" /note="hypothetical protein; expression is regulated by phosphate levels" /db_xref="GeneID:851875" /db_xref="SGD:S000002689" ORIGIN 1 medtsrcidd vlkigqqeke irqaefsdaq gereevkcid ytvdleaglp rhessgksnt 61 lkqcynavlg fleeliivii ivlllysltm vglfyvmtmt kflf // LOCUS NP_010568 414 aa linear PLN 30-JUN-2025 DEFINITION Mrx10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010568 VERSION NP_010568.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180590.3 REFERENCE 1 (residues 1 to 414) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 414) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 414) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 414) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12122. On Jul 30, 2012 this sequence version replaced NP_010568.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..414 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..414 /product="Mrx10p" /calculated_mol_wt="47042" Region 155..350 /region_name="DUF155" /note="RMND1/Sif2-Sif3/Mrx10, DUF155; pfam02582" /db_xref="CDD:460604" CDS 1..414 /gene="MRX10" /locus_tag="YDR282C" /coded_by="NM_001180590.3:1..1245" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:23022099]" /note="Mitochondrial inner membrane hypothetical protein; associates with mitochondrial ribosome; localizes to the inner membrane with the C terminus facing the intermembrane space; ortholog of human RMND1, mutation in which is implicated in infantile encephaloneuromyopathy and defective mitochondrial translation" /db_xref="GeneID:851876" /db_xref="SGD:S000002690" ORIGIN 1 mlsfrsltst fgfvsrfqir rlgtslsiqn levqdgrwkg klatekktnr ehksvdtnik 61 tmkmlknpkn strylrrsfv pnhrkqengr diledslskd hlkvksciti ttgegydlkr 121 cmklltmqgl qptnlipdei vsfsyqdngn kgdvmilgqn gsivswgfse ssvrncivpi 181 vkaaslnpln gedfetedmd yveiegeqdf dklssldnkv tpriacesfl sgdliiinsl 241 dsdqgmldka afssglsrst nlavleeame khisktrtit eniskgtkln lrssdalksi 301 grlflirgkl nlyselietp dlywsepqle eifknvsryl digpriniln skldystdec 361 ralisllner nstflewiii yliafelcfe iyhfyqkyss ycseptnddl datk // LOCUS NP_010569 1659 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine-protein kinase GCN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010569 VERSION NP_010569.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180591.3 REFERENCE 1 (residues 1 to 1659) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1659) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1659) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1659) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12123. On Jul 30, 2012 this sequence version replaced NP_010569.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1659 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1659 /product="serine/threonine-protein kinase GCN2" /EC_number="2.7.11.1" /calculated_mol_wt="190063" Region 12..129 /region_name="RWD_GCN2" /note="RWD domain of eIF-2-alpha kinase GCN2 and related proteins; cd23823" /db_xref="CDD:467659" Region 273..526 /region_name="PK_eIF2AK_GCN2_rpt1" /note="Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; cd14012" /db_xref="CDD:270914" Region 593..979 /region_name="STKc_EIF2AK4_GCN2_rpt2" /note="Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; cd14046" /db_xref="CDD:270948" Site order(593..594,597..598,641..642,645..646,648..649,651, 657..665,667,784,825,828..830) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:270948" Site order(605..606,611,613,626,628,788..791,795,839..840,842, 853,887..889,921,923..930) /site_type="active" /db_xref="CDD:270948" Site order(605..606,613,626,628,656,788..791,835,837,840,842, 853) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270948" Site order(852..861,863..871,878..889) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270948" Site order(887..889,921,923..930) /site_type="other" /note="eIF2alpha (substrate) binding site [polypeptide binding]" /db_xref="CDD:270948" Region 1038..1362 /region_name="HisRS-like_core" /note="Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; cd00773" /db_xref="CDD:238396" Site order(1041,1053,1058..1064,1080..1081,1093,1095,1100..1101, 1104..1105,1132..1133,1140,1151,1155,1158,1324,1349..1350) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238396" Site 1056..1064 /site_type="other" /note="motif 1" /db_xref="CDD:238396" Site order(1093,1095,1120,1122,1131,1134,1136,1140,1297,1299, 1301..1302,1319,1324,1350,1353,1356) /site_type="active" /db_xref="CDD:238396" Site 1119..1123 /site_type="other" /note="motif 2" /db_xref="CDD:238396" Site order(1349..1353,1356) /site_type="other" /note="motif 3" /db_xref="CDD:238396" Region 1387..1657 /region_name="HGTP_anticodon2" /note="Anticodon binding domain of tRNAs; pfam12745" /db_xref="CDD:432758" CDS 1..1659 /gene="GCN2" /locus_tag="YDR283C" /gene_synonym="AAS1; AAS102; NDR2" /coded_by="NM_001180591.3:1..4980" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:7623840]" /experiment="EXISTENCE:direct assay:GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity [PMID:8798780]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:8947054]" /experiment="EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:7934812]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:2038314]" /experiment="EXISTENCE:direct assay:GO:0140469 GCN2-mediated signaling [PMID:8798780]" /experiment="EXISTENCE:genetic interaction:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:6351059]" /experiment="EXISTENCE:mutant phenotype:GO:0000049 tRNA binding [PMID:7623840]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:17890903]" /experiment="EXISTENCE:mutant phenotype:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:6351059|PMID:7623840]" /note="Protein kinase; phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control" /db_xref="GeneID:851877" /db_xref="SGD:S000002691" ORIGIN 1 mslshltldq yyeiqcnele airsiymddf tdltkrkssw dkqpqiifei tlrsvdkepv 61 essitlhfam tpmypytape iefknvqnvm dsqlqmlkse fkkihntsrg qeiifeitsf 121 tqekldefqn vvntqsledd rlqriketke qlekeerekq qetikkrsde qrrideivqr 181 elekrqdddd dllfnrttql dlqppsewva sgeaivfskt ikaklpnnsm fkfkavvnpk 241 pikltsdifs fskqflvkpy ippespladf lmssemmenf yyllseield nsyfntsngk 301 keianlekel etvlkakhdn vnrlfgytve rmgrnnatfv wkirllteyc nyyplgdliq 361 svgfvnlata riwmirlleg leaihklgiv hkcinletvi lvkdadfgst ipklvhstyg 421 ytvlnmlsry pnkngssvel spstwiapel lkfnnakpqr ltdiwqlgvl fiqiisgsdi 481 vmnfetpqef ldstsmdetl ydllskmlnn dpkkrlgtle llpmkflrtn idstinrfnl 541 vsesvnsnsl eltpgdtitv rgnggrtlsq ssirrrsfnv gsrfssinpa trsryasdfe 601 eiavlgqgaf gqvvkarnal dsryyaikki rhteeklsti lsevmllasl nhqyvvryya 661 awleedsmde nvfestdees dlsesssdfe endlldqssi fknrtnhdld nsnwdfisgs 721 gypdivfens srddenedld hdtsstssse sqddtdkesk siqnvprrrn fvkpmtavkk 781 kstlfiqmey cenrtlydli hsenlnqqrd eywrlfrqil ealsyihsqg iihrdlkpmn 841 ifidesrnvk igdfglaknv hrsldilkld sqnlpgssdn ltsaigtamy vatevldgtg 901 hynekidmys lgiiffemiy pfstgmervn ilkklrsvsi efppdfddnk mkvekkiirl 961 lidhdpnkrp gartllnsgw lpvkhqdevi kealkslsnp sspwqqqvre slfnqsyslt 1021 ndilfdnsvp tstpfanilr sqmteevvki frkhggienn apprifpkap iygtqnvyev 1081 ldkggtvlql qydltypmar ylsknpslis kqyrmqhvyr ppdhsrssle prkfgeidfd 1141 iisksssesg fydaeslkii deiltvfpvf ektntffiln hadilesvfn ftnidkaqrp 1201 lvsrmlsqvg farsfkevkn elkaqlniss talndlelfd frldfeaakk rlyklmidsp 1261 hlkkiedsls hiskvlsylk plevarnvvi splsnynsaf ykggimfhav yddgssrnmi 1321 aaggrydtli sffarpsgkk ssntrkavgf nlawetifgi aqnyfklasg nrikkrnrfl 1381 kdtavdwkps rcdvlissfs nslldtigvt ilntlwkqni kadmlrdcss vddvvtgaqq 1441 dgidwillik qqaypltnhk rkykplkikk lstnvdidld ldefltlyqq etgnkslind 1501 sltlgdkade fkrwdenssa gssqegdidd vvagstnnqk viyvpnmatr skkankrekw 1561 vyedaarnss nmilhnlsna piitvdalrd etleiisits laqkeewlrk vfgsgnnstp 1621 rsfatsiynn lskeahkgnr wailychktg kssvidlqr // LOCUS NP_010570 289 aa linear PLN 30-JUN-2025 DEFINITION bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010570 VERSION NP_010570.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180592.1 REFERENCE 1 (residues 1 to 289) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 289) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 289) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 289) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12124. Method: conceptual translation. FEATURES Location/Qualifiers source 1..289 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..289 /product="bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase" /EC_number="3.1.3.4" /EC_number="3.1.3.106" /EC_number="3.6.1.75" /calculated_mol_wt="33383" Region 50..245 /region_name="PAP2_containing_1_like" /note="PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both...; cd03390" /db_xref="CDD:239484" Site order(118,125,167..169,217,223,227) /site_type="active" /db_xref="CDD:239484" CDS 1..289 /gene="DPP1" /locus_tag="YDR284C" /gene_synonym="ZRG1" /coded_by="NM_001180592.1:1..870" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:11139591|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000810 diacylglycerol diphosphate phosphatase activity [PMID:8567632]" /experiment="EXISTENCE:direct assay:GO:0008195 phosphatidate phosphatase activity [PMID:10329682]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:mutant phenotype:GO:0000810 diacylglycerol diphosphate phosphatase activity [PMID:9452443]" /experiment="EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:10329682]" /note="Diacylglycerol pyrophosphate (DGPP) phosphatase; zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism" /db_xref="GeneID:851878" /db_xref="SGD:S000002692" ORIGIN 1 mnrvsfiktp fnigakwrle dvflliimil lnypvyyqqp ferqfyindl tishpyatte 61 rvnnnmlfvy sfvvpsltil iigsiladrr hlifilytsl lglslawfst sfftnfiknw 121 igrlrpdfld rcqpveglpl dtlftakdvc ttknherlld gfrttpsghs sesfaglgyl 181 yfwlcgqllt esplmplwrk mvaflpllga alialsrtqd yrhhfvdvil gsmlgyimah 241 ffyrrifppi ddplpfkplm ddsdvtleea vthqripdee lhplsdegm // LOCUS NP_010571 875 aa linear PLN 30-JUN-2025 DEFINITION Zip1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010571 VERSION NP_010571.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180593.1 REFERENCE 1 (residues 1 to 875) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 875) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 875) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 875) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12125. Method: conceptual translation. FEATURES Location/Qualifiers source 1..875 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..875 /product="Zip1p" /calculated_mol_wt="99904" Region <204..>756 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 479..>749 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" CDS 1..875 /gene="ZIP1" /locus_tag="YDR285W" /coded_by="NM_001180593.1:1..2628" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:26653857]" /experiment="EXISTENCE:direct assay:GO:0000795 synaptonemal complex [PMID:24098146]" /experiment="EXISTENCE:direct assay:GO:0000802 transverse filament [PMID:10662769]" /experiment="EXISTENCE:genetic interaction:GO:0098530 positive regulation of strand invasion [PMID:32386601]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:23593021]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:15805472|PMID:9611194]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15066280]" /experiment="EXISTENCE:mutant phenotype:GO:0033235 positive regulation of protein sumoylation [PMID:27184389|PMID:23326245]" /experiment="EXISTENCE:mutant phenotype:GO:0045128 negative regulation of reciprocal meiotic recombination [PMID:26653857]" /experiment="EXISTENCE:mutant phenotype:GO:1990166 protein localization to site of double-strand break [PMID:23593021]" /experiment="EXISTENCE:physical interaction:GO:0032184 SUMO polymer binding [PMID:16847351]" /note="Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; required for meiotic recombination between non-allelc sites; potential Cdc28p substrate" /db_xref="GeneID:851879" /db_xref="SGD:S000002693" ORIGIN 1 msnffrdssm gfkprpnifa klrvrdvdsd ssantvvens sncldvgssi egddtfkkph 61 ktsteqelit smslsqrnhg ysddmeigsp kkttstdqyn rilkndvaai endtdedfei 121 tevrevsegv aketkeshgd pndsettlkd skmheytmtn gkaplhtsin nsstssndvl 181 leaftntqri csnlkqelqk qqqdnaklkv rlqsyasnsd kinekvgkyk scletlqeri 241 atltshknnq etklkdlrqn hqlyqrrisg fktsienlnk tindlgknkk eadaelmkkg 301 keieylkrel ddcsgqlsee kiknssliqe mgknreemik sienffsedk ahhllqfnkf 361 eervhdlfek klqkhfdvak dtlnvglrnt tvelssntet mlkqqyedik enleqkmsss 421 kdemaktine lsvtqkglim gvqeelltss gniqtalvse mnntrqelld dasqtaknya 481 slenlvkayk aeivqsneye erikhleser stlssqknqi isslgtkeaq yedlvkklea 541 knieisqisg keqsltekne nlsnelkkvq dqleklnnln ittksnyenk issqneivka 601 lvsendtlkq riqqlveike neqkdhttkl eafqknneql qklnvevvql kaheleleeq 661 nrhlknclek ketgveesls dvktlkqqvi vlksekqdit aeklelqdnl esleevtknl 721 qqkvqsqkre leqkikelee iknhkrneps kkgtqnftkp sdspkknatt snlfpnnsaa 781 ihspmkkcpk vdhisksrin ssketskfnd efdlssssnd dleltnpspi qikpvrgkik 841 kgsncmkppi ssrkklllve dedqslkisk krrrk // LOCUS NP_010572 114 aa linear PLN 30-JUN-2025 DEFINITION Mgp12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010572 VERSION NP_010572.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180594.3 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12126. On Jul 30, 2012 this sequence version replaced NP_010572.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..114 /product="Mgp12p" /calculated_mol_wt="13290" Region 23..108 /region_name="Glrx-like" /note="Glutaredoxin-like domain (DUF836); pfam05768" /db_xref="CDD:399055" CDS 1..114 /gene="MGP12" /locus_tag="YDR286C" /coded_by="NM_001180594.3:1..345" /note="Mitochondrial hypothetical protein; predicted to have thiol-disulfide oxidoreductase active site" /db_xref="GeneID:851880" /db_xref="SGD:S000002694" ORIGIN 1 mlrafrcsih tsrvllhdag vkltffskpn cglcdqakev iddvferkef hnkavsleiv 61 nitdrrnakw wkeycfdipv lhiekvgdpk sctkilhfle eddisdkirr mqsr // LOCUS NP_010573 292 aa linear PLN 30-JUN-2025 DEFINITION inositol monophosphate 1-phosphatase INM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010573 VERSION NP_010573.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180595.3 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12127. On Jul 30, 2012 this sequence version replaced NP_010573.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..292 /product="inositol monophosphate 1-phosphatase INM2" /EC_number="3.1.3.25" /calculated_mol_wt="31962" Region 13..265 /region_name="IMPase" /note="inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled...; cd01639" /db_xref="CDD:238817" Site order(41,46,52,75..76,94..99,230..231) /site_type="active" /db_xref="CDD:238817" Site order(45,47,100..101,103..108,161..163,165,167..168, 180..181,184,187..188,191,199..205,213,217..220) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:238817" CDS 1..292 /gene="INM2" /locus_tag="YDR287W" /coded_by="NM_001180595.3:1..879" /experiment="EXISTENCE:direct assay:GO:0008934 inositol monophosphate 1-phosphatase activity [PMID:10096091]" /experiment="EXISTENCE:direct assay:GO:0071545 inositol phosphate catabolic process [PMID:10096091]" /experiment="EXISTENCE:genetic interaction:GO:0008934 inositol monophosphate 1-phosphatase activity [PMID:12593845]" /experiment="EXISTENCE:genetic interaction:GO:0071545 inositol phosphate catabolic process [PMID:12593845]" /experiment="EXISTENCE:mutant phenotype:GO:0008934 inositol monophosphate 1-phosphatase activity [PMID:12593845]" /experiment="EXISTENCE:mutant phenotype:GO:0071545 inositol phosphate catabolic process [PMID:12593845]" /note="Inositol monophosphatase; involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy" /db_xref="GeneID:851881" /db_xref="SGD:S000002695" ORIGIN 1 mvltrqvlee ventfiellr skigplvksh agtnfcsydd kangvdlvta ldkqiesiik 61 enltakypsf kfigeetyvk gvtkitngpt fivdpidgtt nfihgypysc tslglaemgk 121 pvvgvvfnph lnqlfhaskg ngaflndqei kvskrplilq kslialeggs ertegsqgnf 181 dkkmntyknl lsesgafvhg frsagsaamn icyvasgmld ayweggcwaw dvcagwcile 241 eaggimvggn cgewnipldr rcylairggc esmeqkrfae sfwphvagel ey // LOCUS NP_010574 303 aa linear PLN 30-JUN-2025 DEFINITION Smc5-Smc6 complex subunit NSE3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010574 VERSION NP_010574.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180596.1 REFERENCE 1 (residues 1 to 303) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 303) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 303) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 303) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12128. Method: conceptual translation. FEATURES Location/Qualifiers source 1..303 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..303 /product="Smc5-Smc6 complex subunit NSE3" /calculated_mol_wt="33834" Region 31..269 /region_name="MAGE" /note="MAGE homology domain; pfam01454" /db_xref="CDD:426270" CDS 1..303 /gene="NSE3" /locus_tag="YDR288W" /coded_by="NM_001180596.1:1..912" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391]" /note="Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851882" /db_xref="SGD:S000002696" ORIGIN 1 mssidndsdv dltedlavak ivkenpvark mvryilsrge sqnsiitrnk lqsviheaar 61 eeniakpsfs kmfmdinail ynvygfelqg lpsknnmnag gngsnsntnk smpeplghra 121 qkfillnnvp hsknfddfki lqsahtyeel ivtgeyigdd iasgtsntle sklstdrdlv 181 ykgvlsvilc ivffsknnil hqelikflet fgipsdgski ailnitiedl ikslekreyi 241 vrleeksdtd gevisyrigr rtqaelgles leklvqeimg lekeqtkslh ddiiksigds 301 ysi // LOCUS NP_010575 409 aa linear PLN 30-JUN-2025 DEFINITION Rtt103p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010575 VERSION NP_010575.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180597.1 REFERENCE 1 (residues 1 to 409) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 409) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 409) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 409) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12129. Method: conceptual translation. FEATURES Location/Qualifiers source 1..409 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..409 /product="Rtt103p" /calculated_mol_wt="46357" Region 5..131 /region_name="CID_Rtt103" /note="CID (CTD-Interacting Domain) of yeast transcription termination factor Rtt103 and similar proteins; cd17003" /db_xref="CDD:340800" Site order(16..20,22..23,27,62,65..66,69..70,108..109,112) /site_type="other" /note="CTD binding site [polypeptide binding]" /db_xref="CDD:340800" CDS 1..409 /gene="RTT103" /locus_tag="YDR289C" /coded_by="NM_001180597.1:1..1230" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:15565157]" /experiment="EXISTENCE:direct assay:GO:0035861 site of double-strand break [PMID:22355353]" /experiment="EXISTENCE:direct assay:GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding [PMID:20818393]" /experiment="EXISTENCE:genetic interaction:GO:0031124 mRNA 3'-end processing [PMID:15565157]" /experiment="EXISTENCE:mutant phenotype:GO:0010526 transposable element silencing [PMID:11779788]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:15565157]" /experiment="EXISTENCE:physical interaction:GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding [PMID:15565157]" /note="Protein implicated in transcription termination by RNA polymerase II; binds to the RNA polymerase II C-terminal domain (CTD) phosphorylated on serine (ser2); interacts with 5' to 3' exonuclease Rat1p and decapping endonuclease Rai1p and is involved in mRNA 3' end processing; contains an RPR domain (CTD-interacting domain); involved in regulation of Ty1 transposition" /db_xref="GeneID:851884" /db_xref="SGD:S000002697" ORIGIN 1 mpfsseqftt klntledsqe sissaskwll lqyrdapkva emwkeymlrp svntrrkllg 61 lylmnhvvqq akgqkiiqfq dsfgkvaaev lgrinqefpr dlkkklsrvv nilkernifs 121 kqvvndiers lktesspvea lvlpqklkdf akdyeklvkm hhnvcamkmr fdkssdeldp 181 sssvyeenfk tiskignmak diinesilkr esgihklqst lddekrhlde eqnmlseief 241 vlsakdpsrl nknvdednii ptyevgdgdd ddddgdnddd dddddddkny ddrsndsnyg 301 vtnisttdkk nevvektdse hknsthnpsd nqfgmkrthd mighddandi pekkvhldsk 361 tsedgtfnse dghyeldieg hvgaqtdegv ensggvsssi qdllsklan // LOCUS NP_010577 1077 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent 3'-5' DNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010577 VERSION NP_010577.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180599.3 REFERENCE 1 (residues 1 to 1077) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1077) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1077) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1077) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1077) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1077) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1077) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1077) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1077) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12130. On Jul 30, 2012 this sequence version replaced NP_010577.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1077 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1077 /product="ATP-dependent 3'-5' DNA helicase" /EC_number="3.6.4.12" /calculated_mol_wt="123419" Region 239..1018 /region_name="YprA" /note="ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair]; COG1205" /db_xref="CDD:440818" CDS 1..1077 /gene="HRQ1" /locus_tag="YDR291W" /coded_by="NM_001180599.3:1..3234" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:24440721]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:32371399]" /experiment="EXISTENCE:direct assay:GO:0032075 positive regulation of nuclease activity [PMID:32371399]" /experiment="EXISTENCE:direct assay:GO:0036297 interstrand cross-link repair [PMID:32371399]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:30068549|PMID:24440721]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:28385527|PMID:24440721|PMID:23026052]" /experiment="EXISTENCE:genetic interaction:GO:0006289 nucleotide-excision repair [PMID:24682993]" /experiment="EXISTENCE:genetic interaction:GO:0032204 regulation of telomere maintenance [PMID:24440721]" /experiment="EXISTENCE:mutant phenotype:GO:0032075 positive regulation of nuclease activity [PMID:32371399]" /experiment="EXISTENCE:mutant phenotype:GO:0032202 telomere assembly [PMID:24440721]" /experiment="EXISTENCE:mutant phenotype:GO:0042275 error-free postreplication DNA repair [PMID:36126066]" /experiment="EXISTENCE:physical interaction:GO:0006289 nucleotide-excision repair [PMID:24682993]" /note="3'-5' DNA helicase of the conserved RecQ family; involved in Pso2p-mediated interstrand crosslink repair; acts with Rad4p in nucleotide-excision repair; binds telomeres, modulates telomerase activity with Pif1p and inhibits telomere addition to dsDNA breaks; role in telomerase-independent telomere maintenance; lacks ssDNA annealing and strand exchange activities; human RecQL4, a structural and functional homolog, is involved in Rothmund-Thomson, Baller-Gerold and RAPADILINO syndromes" /db_xref="GeneID:851885" /db_xref="SGD:S000002699" ORIGIN 1 meegpikkkl ksagqgsgkt dafrnfeqff frlntlytfl icrkhvvptf ktlcgpieta 61 lkrtvtkedl amvmalmpre cvfkyidenq iytetkifdf nnggfqqken difelkdvdd 121 qnqtqkstql lifefidgtm qrswsasdrf sqikiptytt eemkkmiskr ealfksrlre 181 filekekanl dpfseltnla qkyiprerdy edpieammka kqesnemsip nysnnsvitt 241 ipqmieklks tefyasqikh cftipsrtak ykglcfelap evyqgmehen fyshqadain 301 slhqgenvii ttstssgksl iyqlaaidll lkdpestfmy ifptkalaqd qkrafkvils 361 kipelknavv dtydgdtepe erayirknar viftnpdmih tsilpnhanw rhflyhlklv 421 vvdelhiykg lfgshvalvm rrllrlchcf yensglqfis csatlkspvq hmkdmfgine 481 vtlihedgsp tgakhlvvwn ppilpqherk renfiresak ilvqlilnnv rtiafcyvrr 541 vcellmkevr nifietgred lvtevmsyrg gysasdrrki eremfhgnlk avistnalel 601 gidiggldav lmcgfplsma nfhqqsgrag rrnndsltlv vasdspvdqh yvahpeslle 661 vnnfesyqdl vldfnnilil eghiqcaafe lpinferdkq yfteshlrki cverlhhnqd 721 gyhasnrflp wpskcvslrg geedqfavvd itngrniiie eieasrtsft lydggifihq 781 gypylvkefn pderyakvqr vdvdwvtnqr dftdvdpqei elirslrnsd vpvyfgkikt 841 tiivfgffkv dkykriidai ethnppviin skglwidmpk yaleicqkkq lnvagaihga 901 qhaimgmlpr fivagvdeiq teckapekef aerqtkrkrp arlifydskg gkygsglcvk 961 afehiddiie sslrrieecp csdgcpdcva asfckenslv lskpgaqvvl hcilghseds 1021 fidlikdgpe pnmpeikvet vipvsehvnf sddfkiidvr ratkddthtn eiikkei // LOCUS NP_010578 621 aa linear PLN 30-JUN-2025 DEFINITION signal recognition particle receptor subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_010578 VERSION NP_010578.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180600.3 REFERENCE 1 (residues 1 to 621) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 621) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 621) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 621) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 621) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 621) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 621) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 621) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 621) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12131. On Jul 30, 2012 this sequence version replaced NP_010578.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..621 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..621 /product="signal recognition particle receptor subunit alpha" /calculated_mol_wt="69147" Region 1..155 /region_name="SRX" /note="signal recognition particle receptor alpha subunit; pfam09201" /db_xref="CDD:370358" Region 300..370 /region_name="SRP54_N" /note="SRP54-type protein, helical bundle domain; pfam02881" /db_xref="CDD:460734" Region 398..619 /region_name="SRalpha_C" /note="C-terminal domain of signal recognition particle receptor alpha subunit; cd17876" /db_xref="CDD:349785" Site order(405..412,416,434,437,443,513,573,575,599..602) /site_type="active" /db_xref="CDD:349785" Site order(406..407,436..439,442..443,446..447,482,513,515..517, 542,544..548,551,573,575..576,578,602) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:349785" CDS 1..621 /gene="SRP101" /locus_tag="YDR292C" /coded_by="NM_001180600.3:1..1866" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9679135]" /experiment="EXISTENCE:mutant phenotype:GO:0005047 signal recognition particle binding [PMID:1327299]" /experiment="EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:1327299]" /experiment="EXISTENCE:physical interaction:GO:0005785 signal recognition particle receptor complex [PMID:9679135]" /note="Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p" /db_xref="GeneID:851886" /db_xref="SGD:S000002700" ORIGIN 1 mfdqlavftp qgqvlyqync lgkkfseiqi nsfisqlits pvtrkesvan antdgfdfnl 61 ltinsehkns psfnalfyln kqpelyfvvt faeqtlelnq etqqtlalvl klwnslhlse 121 silknrqgqn eknkhnyvdi lqgieddlkk feqyfrikye esikqdhinp dnftkngsvp 181 qshnkntkkk lrdtkgkkqs tgnvgsgrkw grdggmldem nhedaakldf sssnshnssq 241 valdstinkd sfgdrteggd flikeiddll sshkdeitsg neaknsgyvs tafgflqkhv 301 lgnktinesd lksvlekltq qlitknvape aadyltqqvs hdlvgsktan wtsventare 361 sltkaltqil tpgvsvdllr eiqskrskkd eegkcdpyvf sivgvngvgk stnlsklafw 421 llqnnfkvli vacdtfrsga veqlrvhven laqlmddshv rgsknkrgkt gndyvelfea 481 gyggsdlvtk iakqaikysr dqnfdivlmd tagrrhndpt lmsplksfad qakpdkiimv 541 gealvgtdsv qqaknfndaf gkgrnldffi iskcdtvgem lgtmvnmvya tgipilfvgv 601 gqtytdlrtl svkwavntlm s // LOCUS NP_010579 1250 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding translational repressor SSD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010579 VERSION NP_010579.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180601.1 REFERENCE 1 (residues 1 to 1250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1250) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12132. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1250 /product="mRNA-binding translational repressor SSD1" /calculated_mol_wt="139824" Region 582..657 /region_name="OB_Dis3" /note="Dis3-like cold-shock domain 2 (CSD2); pfam17849" /db_xref="CDD:436091" Region 689..1014 /region_name="RNB" /note="RNB domain; pfam00773" /db_xref="CDD:459934" Region 1064..1151 /region_name="Dis3l2_C_term" /note="DIS3-like exonuclease 2 C terminal; pfam17877" /db_xref="CDD:465547" CDS 1..1250 /gene="SSD1" /locus_tag="YDR293C" /gene_synonym="CLA1; MCS1; RLT1; SRK1" /coded_by="NM_001180601.1:1..3753" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:21339329|PMID:19962308]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640|PMID:31909711|PMID:19962308]" /experiment="EXISTENCE:direct assay:GO:0003730 mRNA 3'-UTR binding [PMID:24465507]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21762218]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9195905|PMID:19962308]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:21339329]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:21339329]" /experiment="EXISTENCE:direct assay:GO:0008298 intracellular mRNA localization [PMID:31909711]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:21339329]" /experiment="EXISTENCE:direct assay:GO:0048027 mRNA 5'-UTR binding [PMID:20977549]" /experiment="EXISTENCE:genetic interaction:GO:0000900 mRNA regulatory element binding translation repressor activity [PMID:19962308]" /experiment="EXISTENCE:genetic interaction:GO:0017148 negative regulation of translation [PMID:19962308]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:19962308]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:21339329]" /experiment="EXISTENCE:mutant phenotype:GO:1903450 regulation of G1 to G0 transition [PMID:31141453]" /note="Translational repressor; involved in polar growth, wall integrity, autodiploidization; regulated by Cbk1p phosphorylation to affect bud-specific translational control and localization of specific mRNAs; binds 5'UTRs of mRNAs encoding cell wall proteins; recognizes CNYTCNYT motif in RNA; interacts with TOR pathway components; nucleocytoplasmic shuttling appears to be critical to Ssd1p function; W303 lacks a functional SSD1 gene product; pseudonuclease descended from Dis3L2-family nucleases" /db_xref="GeneID:851887" /db_xref="SGD:S000002701" ORIGIN 1 msknsnvnnn rsqepnnmfv qttgggknap kqihvahrrs qseltnlmie qftlqkqleq 61 vqaqqqqlma qqqqlaqqtg qylsgnsgsn nhftpqpphp hynsngnspg msaggsrsrt 121 hsrnnsgyyh nsydnnnnsn npgsnshrkt ssqssiyghs rrhslglnea kkaaaeeqak 181 risggeagvt vkidsvqads gsnstteqsd fkfppppnah qghrratsnl sppsfkfppn 241 shgdnddefi atssthrrsk trnneyspgi nsnwrnqsqq pqqqlspfrh rgsnsrdyns 301 fntleppaif qqghkhrasn ssvhsfssqg nnngggrksl fapylpqani peliqegrlv 361 agilrvnkkn rsdawvstdg aldadiyicg skdrnraleg dlvavellvv ddvweskkek 421 eekkrrkdas mqhdliplns sddyhndasv taatsnnfls spsssdslsk ddlsvrrkrs 481 stinndsdsl ssptksgvrr rsslkqrptq kknddveveg qslllveeee indkykplya 541 ghvvavldri pgqlfsgtlg llrpsqqans dnnkppqspk iawfkptdkk vpliaiptel 601 apkdfvenad kyseklfvas ikrwpitslh pfgilvselg dihdpdteid silrdnnfls 661 neyldqknpq kekpsfqplp ltaesleyrr nftdtneyni faiselgwvs efalhvrnng 721 ngtlelgchv vdvtshieeg ssvdrrarkr ssavfmpqkl vnllpqsfnd elslapgkes 781 atlsvvytld sstlrikstw vgestispsn ilsleqldek lstgsptsyl stvqeiarsf 841 yarrindpea tllptlslle slddekvkvd lnildrtlgf vvineikrkv nstvaekiyt 901 klgdlallrr qmqpiatkma sfrkkiqnfg ynfdtntade likgvlkikd ddvrvgieil 961 lfktmprary fiagkvdpdq yghyalnlpi ythftapmrr yadhvvhrql kavihdtpyt 1021 edmealkits eycnfkkdca yqaqeqaihl llcktindmg nttgqlltma tvlqvyessf 1081 dvfipefgie krvhgdqlpl ikaefdgtnr vlelhwqpgv dsatfipade knpksyrnsi 1141 knkfrstaae ianieldkea eseplisdpl skelsdlhlt vpnlrlpsas dnkqnalekf 1201 isttetrien dnyiqeihel qkipillrae vgmalpcltv ralnpfmkrv // LOCUS NP_010580 589 aa linear PLN 30-JUN-2025 DEFINITION sphinganine-1-phosphate aldolase DPL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010580 VERSION NP_010580.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180602.1 REFERENCE 1 (residues 1 to 589) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 589) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 589) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 589) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12133. Method: conceptual translation. FEATURES Location/Qualifiers source 1..589 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..589 /product="sphinganine-1-phosphate aldolase DPL1" /EC_number="4.1.2.27" /calculated_mol_wt="65435" Region 169..532 /region_name="DOPA_deC_like" /note="DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; cd06450" /db_xref="CDD:99743" Site order(235..236,239,313,342,345,377,380) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99743" Site 380 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99743" CDS 1..589 /gene="DPL1" /locus_tag="YDR294C" /gene_synonym="BST1" /coded_by="NM_001180602.1:1..1770" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008117 sphinganine-1-phosphate aldolase activity [PMID:9334171]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:18487605]" /experiment="EXISTENCE:direct assay:GO:0097038 perinuclear endoplasmic reticulum [PMID:18487605]" /experiment="EXISTENCE:mutant phenotype:GO:0006665 sphingolipid metabolic process [PMID:9334171]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:10329480]" /experiment="EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:11278643]" /note="Dihydrosphingosine phosphate lyase; regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate; localizes to the ER and to the peroxisome" /db_xref="GeneID:851888" /db_xref="SGD:S000002702" ORIGIN 1 msgvsnktvs ingwygmpih llreegdfaq fmiltinelk iaihgylrnt pwynmlkdyl 61 fvifcyklis nffyllkvyg pvrlavrtye hssrrlfrwl ldspflrgtv ekevtkvkqs 121 iedelirsds qlmnfpqlps ngipqddvie elnklndlip htqwkegkvs gavyhggddl 181 ihlqtiayek ycvanqlhpd vfpavrkmes evvsmvlrmf napsdtgcgt ttsggtesll 241 laclsakmya lhhrgitepe iiapvtahag fdkaayyfgm klrhveldpt tyqvdlgkvk 301 kfinkntill vgsapnfphg iaddieglgk iaqkyklplh vdsclgsfiv sfmekagykn 361 lplldfrvpg vtsiscdthk ygfapkgssv imyrnsdlrm hqyyvnpawt gglygsptla 421 gsrpgaivvg cwatmvnmge ngyiescqei vgaamkfkky iqenipdlni mgnprysvis 481 fssktlnihe lsdrlskkgw hfnalqkpva lhmaftrlsa hvvdeicdil rttvqelkse 541 snskpspdgt salygvagsv ktagvadkli vgfldalykl gpgedtatk // LOCUS NP_010581 674 aa linear PLN 30-JUN-2025 DEFINITION Hda2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010581 VERSION NP_010581.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180603.3 REFERENCE 1 (residues 1 to 674) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 674) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 674) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 674) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12134. On Jul 30, 2012 this sequence version replaced NP_010581.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..674 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..674 /product="Hda2p" /calculated_mol_wt="76929" Region 11..319 /region_name="HDA2-3" /note="Class II histone deacetylase complex subunits 2 and 3; pfam11496" /db_xref="CDD:402894" Region <445..>641 /region_name="sbcc" /note="exonuclease SbcC; TIGR00618" /db_xref="CDD:129705" CDS 1..674 /gene="HDA2" /locus_tag="YDR295C" /gene_synonym="PLO2" /coded_by="NM_001180603.3:1..2025" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:19573535]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16415367]" /experiment="EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:19573535]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0070823 HDA1 complex [PMID:11287668]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11287668]" /experiment="EXISTENCE:mutant phenotype:GO:0031047 regulatory ncRNA-mediated gene silencing [PMID:18022365]" /experiment="EXISTENCE:physical interaction:GO:0070823 HDA1 complex [PMID:11287668]" /note="Subunit of HDA1 histone deacetylase complex; tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; Hda2p relocalizes to cytosol in response to hypoxia; other members of the HDA1 histone deacetylase complex, which regulates aging through trehalose metabolism, are Hda1p and Hda3p" /db_xref="GeneID:851889" /db_xref="SGD:S000002703" ORIGIN 1 msrknskklk vyylpvtltq fqkdlseili slhaksfkas iigepqadav nkpsglpagp 61 ethpyptlsq rqltyifdsn iraianhpsl lvdhymprql lrmeptessi agshkfqvln 121 qlinsicfrd regspnevik caiiahsike ldlleglilg kkfrtkrlsg tslynekhkf 181 pnlptvdsti nkdgtpnsvs stssnsnsts ytgyskddyd ysvkrnlkkr kintddwlfl 241 attkhlkhdq yllanydidm iisfdpmlev elpalqvlrn nankdipiik llvqnspdhy 301 lldseiknss vksshlsnng hvddsqeyee ikssllyflq arnapvnnce idyiklvkcc 361 legkdcnnil pvldlitlde askdssdsgf wqpqltklqy sstelplwdg pldiktyqte 421 lmhravirlr diqdeyakgt vplyekrlne tqrqnqldei knsvgltfkk kqeveksind 481 sekrlkhamt estklqnkin hllknrqele nfnklpsnti ssenhleegs aladklkeyi 541 dknatlfnkl kelqqanaek sklndelrsk yqiesskaae saqtlkilqe smkslenevn 601 gpltkfstes lkkelerlqn dfqslkarnk flknyitlmn rqydlknknn vqvekaaang 661 trfrstrsnt pnyt // LOCUS NP_010582 226 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL67 MHR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010582 VERSION NP_010582.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180604.3 REFERENCE 1 (residues 1 to 226) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 226) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 226) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12135. On Jul 30, 2012 this sequence version replaced NP_010582.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..226 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..226 /product="mitochondrial 54S ribosomal protein mL67 MHR1" /calculated_mol_wt="26764" Region 24..106 /region_name="Mhr1" /note="Transcriptional regulation of mitochondrial recombination; pfam12829" /db_xref="CDD:463721" CDS 1..226 /gene="MHR1" /locus_tag="YDR296W" /gene_synonym="mL67; XTC1" /coded_by="NM_001180604.3:1..681" /experiment="EXISTENCE:direct assay:GO:0000002 mitochondrial genome maintenance [PMID:12034822]" /experiment="EXISTENCE:direct assay:GO:0000150 DNA strand exchange activity [PMID:12198175]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12198175]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:19729448]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:24675956]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12034822]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:12034822|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:24675956]" /experiment="EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:12198175]" /experiment="EXISTENCE:mutant phenotype:GO:0000150 DNA strand exchange activity [PMID:12198175]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:12198175]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:19074198]" /experiment="EXISTENCE:mutant phenotype:GO:0090297 positive regulation of mitochondrial DNA replication [PMID:17116696|PMID:19074198]" /experiment="EXISTENCE:physical interaction:GO:0006355 regulation of DNA-templated transcription [PMID:9736700]" /note="Mitochondrial ribosomal protein of the large subunit; also involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress" /db_xref="GeneID:851890" /db_xref="SGD:S000002704" ORIGIN 1 mkvnhsisrf rpaswfektk iippqvyifr nleygqvlys qfpnfsqtqv dklfvrpnws 61 nrkpslrrdi wkcmcvvnlq nykqsvhlyq nlcrlrylrd vaqrkesdkl rkkdsnghvw 121 ysgqyrptyc qeavadlres llkvfenatp aekqtvpakk psiywedpwr mgdkdkhwny 181 dvfnalgleh kliqrvgnia reesvilkel akleshpteq tevssq // LOCUS NP_010583 349 aa linear PLN 30-JUN-2025 DEFINITION sphingosine hydroxylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010583 VERSION NP_010583.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180605.1 REFERENCE 1 (residues 1 to 349) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 349) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 349) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 349) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12136. Method: conceptual translation. FEATURES Location/Qualifiers source 1..349 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..349 /product="sphingosine hydroxylase" /calculated_mol_wt="40603" Region 161..297 /region_name="FA_hydroxylase" /note="Fatty acid hydroxylase; pfam04116" /db_xref="CDD:397991" CDS 1..349 /gene="SUR2" /locus_tag="YDR297W" /gene_synonym="SYR2" /coded_by="NM_001180605.1:1..1050" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8868422]" /experiment="EXISTENCE:mutant phenotype:GO:0006665 sphingolipid metabolic process [PMID:9556590]" /experiment="EXISTENCE:mutant phenotype:GO:0102772 sphingolipid C4-monooxygenase activity [PMID:9556590]" /note="Sphinganine C4-hydroxylase; catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis" /db_xref="GeneID:851891" /db_xref="SGD:S000002705" ORIGIN 1 mnvtsnataa gsfplafglk tsfgfmhyak apainlrpke sllpemsdgv lalvapvvay 61 walsgifhvi dtfhlaekyr ihpseevakr nkasrmhvfl evilqhiiqt ivglifmhfe 121 piymtgfeen amwklradlp riipdaaiyy gymygmsalk ifagflfvdt wqyflhrlmh 181 mnktlykwfh svhhelyvpy aygalfnnpv egflldtlgt giamtlthlt hreqiilftf 241 atmktvddhc gyalpldpfq wlfpnnavyh dihhqqfgik tnfaqpfftf wdnlfqtnfk 301 gfeeyqkkqr rvtidkykef lqerelekke klknfkamna aenevkkek // LOCUS NP_010584 212 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit 5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010584 VERSION NP_010584.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180606.1 REFERENCE 1 (residues 1 to 212) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 212) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 212) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 212) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12137. Method: conceptual translation. FEATURES Location/Qualifiers source 1..212 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..212 /product="F1F0 ATP synthase subunit 5" /calculated_mol_wt="22683" Region 32..208 /region_name="OSCP" /note="ATP synthase delta (OSCP) subunit; pfam00213" /db_xref="CDD:459714" CDS 1..212 /gene="ATP5" /locus_tag="YDR298C" /gene_synonym="OSC1" /coded_by="NM_001180606.1:1..639" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0045259 proton-transporting ATP synthase complex [PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:2146269|PMID:15254373]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:2146269]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:7866306]" /note="Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated" /db_xref="GeneID:851892" /db_xref="SGD:S000002706" ORIGIN 1 mfnrvftrsf asslraaask aaapppvrlf gvegtyatal yqaaaknssi daafqslqkv 61 estvkknpkl ghlllnpals lkdrnsvida ivethknldg yvvnllkvls ennrlgcfek 121 iasdfgvlnd ahngllkgtv tsaepldpks fkriekalsa sklvgqgksl klenvvkpei 181 kgglivelgd ktvdlsistk iqklnkvled si // LOCUS NP_010585 534 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein BFR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010585 VERSION NP_010585.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180607.3 REFERENCE 1 (residues 1 to 534) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 534) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 534) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 534) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12138. On Jul 30, 2012 this sequence version replaced NP_010585.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..534 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..534 /product="rRNA-processing protein BFR2" /calculated_mol_wt="61072" Region 172..300 /region_name="AATF-Che1" /note="Apoptosis antagonizing transcription factor; pfam13339" /db_xref="CDD:463850" Region 414..498 /region_name="TRAUB" /note="Apoptosis-antagonizing transcription factor, C-terminal; pfam08164" /db_xref="CDD:462388" CDS 1..534 /gene="BFR2" /locus_tag="YDR299W" /coded_by="NM_001180607.3:1..1605" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:24357410]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0032040 small-subunit processome [PMID:24357410]" /note="Component of the SSU and 90S preribosomes; involved in pre-18S rRNA processing; binds to U3 snoRNA and Mpp10p; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock" /db_xref="GeneID:851893" /db_xref="SGD:S000002707" ORIGIN 1 meksladqis diaikpvnkd fdiedeenas lfqhneknge sdlsdygnsn teetkkahyl 61 eveksklrae kglelndpky tgvkgsrqal yeevsenede eeeeeeeeek eedalsfrtd 121 sedeeveide eesdadgget eeaqqkrhal skliqqetkq ainklsqsvq rdaskgysil 181 qqtklfdnii dlriklqkav iaanklpltt esweeakmdd seetkrllke neklfnnlfn 241 rlinfrikfq lgdhitqnee vakhklskkr slkelyqetn sldselkeyr tavlnkwstk 301 vssasgnaal ssnkfkainl padvqvenql sdmsrlmkrt klnrrnitpl yfqkdcangr 361 lpelispvvk dsvddnensd dgldipknyd prrkdnnaid itenpyvfdd edfyrvllnd 421 lidkkisnah nsesaaitit stnarsnnkl kknidtkask grklnysvqd pianyeapit 481 sgykwsddqi deffagllgq rvnfnenede eqhariende eleavknddi qifg // LOCUS NP_010586 428 aa linear PLN 30-JUN-2025 DEFINITION glutamate 5-kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010586 VERSION NP_010586.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180608.3 REFERENCE 1 (residues 1 to 428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 428) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12139. On Jul 30, 2012 this sequence version replaced NP_010586.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..428 /product="glutamate 5-kinase" /EC_number="2.7.2.11" /calculated_mol_wt="47031" Region 10..425 /region_name="proB" /note="glutamate 5-kinase; TIGR01027" /db_xref="CDD:162163" CDS 1..428 /gene="PRO1" /locus_tag="YDR300C" /coded_by="NM_001180608.3:1..1287" /experiment="EXISTENCE:direct assay:GO:0004349 glutamate 5-kinase activity [PMID:12513997]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:25112878]" /experiment="EXISTENCE:direct assay:GO:0006561 proline biosynthetic process [PMID:12513997]" /experiment="EXISTENCE:genetic interaction:GO:0034517 ribophagy [PMID:27442630]" /experiment="EXISTENCE:mutant phenotype:GO:0004349 glutamate 5-kinase activity [PMID:2824433]" /experiment="EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:27442630]" /note="Cytosolic gamma-glutamyl kinase; catalyzes the first step in proline biosynthesis; required for nitrogen starvation-induced ribophagy but not for nonselective autophagy; PRO1 has a paralog, YHR033W, that arose from the whole genome duplication" /db_xref="GeneID:851894" /db_xref="SGD:S000002708" ORIGIN 1 mkdanesksy tiviklgsss lvdektkepk laimslivet vvklrrmghk viivssggia 61 vglrtmrmnk rpkhlaevqa iaaigqgrli grwdllfsqf dqriaqillt rndildwtqy 121 knaqntinel lnmgvipivn endtlsvrei kfgdndtlsa itsalihady lflltdvdcl 181 ytdnprtnpd ampilvvpdl skglpgvnta ggsgsdvgtg gmetklvaad latnagvhtl 241 imksdtpani griveymqtl elddenkvkq ayngdltdlq krefeklkal nvplhtkfia 301 ndnkhhlknr efwilhglvs kgavvidqga yaaltrknka gllpagvidv qgtfhelecv 361 dikvgkklpd gtldpdfplq tvgkarcnyt sseltkikgl hsdqieeelg yndseyvahr 421 enlafppr // LOCUS NP_010587 1357 aa linear PLN 30-JUN-2025 DEFINITION cleavage/polyadenylation factor CFT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010587 VERSION NP_010587.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180609.1 REFERENCE 1 (residues 1 to 1357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1357) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12140. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1357 /product="cleavage/polyadenylation factor CFT1" /calculated_mol_wt="153275" Region 1..1353 /region_name="SFT1" /note="Pre-mRNA cleavage and polyadenylation specificity factor [RNA processing and modification]; COG5161" /db_xref="CDD:227490" CDS 1..1357 /gene="CFT1" /locus_tag="YDR301W" /gene_synonym="YHH1" /coded_by="NM_001180609.1:1..4074" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9099738]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:10523662|PMID:12819204]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:12145212]" /note="RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF" /db_xref="GeneID:851895" /db_xref="SGD:S000002709" ORIGIN 1 mnvyddvlda tvvshslath fttsdyeell vvrtnilsvy rptrdgklyl tdefkfhgli 61 tdiglipqkd splsclllct gvakisilkf ntltnsidtl slhyyegkfk gkslvelaki 121 stlrmdpgss callfnndii aflpfhvnkn dddeeeeded eniddselih smnqksqgtn 181 tfnkrkrtkl gdkftapsvv lvaselyega kniidiqflk nftkptiall yqpklvwagn 241 ttisklptqy viltlniqpa esatkiestt iafvkelpwd lhtivpvsng aiivgtnela 301 fldntgvlqs tvllnsfadk elqktkiinn ssleimfrek nttsiwipss ksknggsnnd 361 etlllmdlks niyyiqmeae grllikfdif klpivndllk ensnpkcitr lnatnsnknm 421 dlfigfgsgn alvlrlnnlk stietreahn pssgtnslmd inddddeemd dlyadeapen 481 glttndskgt vetvqpfdie llsslrnvgp itsltvgkvs siddvvkglp npnkneyslv 541 atsgngsgsh ltviqtsvqp eielalkfis itqiwnlkik grdrylittd stksrsdiye 601 sdnnfklhkg grlrrdattv yismfgeekr iiqvttnhly lydthfrrlt tikfdyevih 661 vsvmdpyilv tvsrgdikif eleeknkrkl lkvdlpeiln emvitsglil ksnmcnefli 721 glsksqeeql lftfvtadnq iifftkdhnd rifqlngvdq lneslyisty qlgdeivpdp 781 sikqvminkl ghdnkeeylt iltfggeiyq yrklpqrrsr fyrnvtrndl aitgapdnay 841 akgvssieri mhyfpdyngy svifvtgsvp yilikeddst pkifkfgnip lvsvtpwser 901 svmcvddikn arvytlttdn myygnklplk qikisnvldd yktlqklvyh eraqlflvsy 961 ckrvpyealg edgekvigyd envphaegfq sgillinpks wkvidkidfp knsvvnemrs 1021 smiqinsktk rkreyiiagv anattedtpp tgafhiydvi evvpepgkpd tnyklkeifq 1081 eevsgtvstv cevsgrfmis qsqkvlvrdi qednsvipva fldipvfvtd sksfgnllii 1141 gdamqgfqfi gfdaepyrmi slgrsmskfq tmsleflvng gdmyfaatda drnvhvlkya 1201 pdepnslsgq rlvhcssftl hstnscmmll prneefgspq vpsfqnvggq vdgsvfkivp 1261 lseekyrrly viqqqiidre lqlgglnprm erlandfyqm ghsmrpmldf nvirrfcgla 1321 idrrksiaqk agrhahfeaw rdiiniefsm rslcqgk // LOCUS NP_010588 219 aa linear PLN 30-JUN-2025 DEFINITION mannose-ethanolamine phosphotransferase GPI11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010588 VERSION NP_010588.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180610.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12141. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..219 /product="mannose-ethanolamine phosphotransferase GPI11" /calculated_mol_wt="25131" Region 50..216 /region_name="PIG-F" /note="GPI biosynthesis protein family Pig-F; pfam06699" /db_xref="CDD:461990" CDS 1..219 /gene="GPI11" /locus_tag="YDR302W" /coded_by="NM_001180610.1:1..660" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:10793139]" /experiment="EXISTENCE:mutant phenotype:GO:0051377 mannose-ethanolamine phosphotransferase activity [PMID:10793139]" /note="ER membrane protein involved in a late step of GPI anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated glycosylphosphatidylinositol (GPI) intermediate; human PIG-Fp is a functional homolog" /db_xref="GeneID:851896" /db_xref="SGD:S000002710" ORIGIN 1 mpakkrtrkt vkktvsfsdd ttltthqnre kknvdhdrpp vyvrktplmt fpyhlvally 61 yyvfvssnfn tvkllsflip tqvaylvlqf nkctvygnki ikinysltii clgvtfllsf 121 ptmlltilfg aplmdllwet wllslhfafl aypavysvfn cdfkvglwkk yfifivvggw 181 iscvvipldw drdwqnwpip ivvggylgal vgytigayi // LOCUS NP_010589 885 aa linear PLN 30-JUN-2025 DEFINITION Rsc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010589 VERSION NP_010589.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180611.3 REFERENCE 1 (residues 1 to 885) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 885) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 885) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 885) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12142. On Jul 30, 2012 this sequence version replaced NP_010589.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..885 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..885 /product="Rsc3p" /calculated_mol_wt="101590" Region 8..48 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(9,13,18..21,23,26,36) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(14,17,24,31,34,42) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..885 /gene="RSC3" /locus_tag="YDR303C" /coded_by="NM_001180611.3:1..2658" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]" /experiment="EXISTENCE:genetic interaction:GO:0033262 regulation of nuclear cell cycle DNA replication [PMID:17542652]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11336698]" /note="Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; RSC3 has a paralog, RSC30, that arose from the whole genome duplication" /db_xref="GeneID:851897" /db_xref="SGD:S000002711" ORIGIN 1 mdirgrkmkk ppacvqcrkr kigcdrvkpi cgncmkhnkm dcfypdvpgq yvpssssssn 61 trqvangpyl nsyyasrrvs ketaallqkn pelasleqir eyntrlqlln aqnqlnnrss 121 aanatlnqqh tqyipksvps leskpvtsan esstplnwvq gpaifhmlts pytqdeiinh 181 emnflkgrll elqeitgkki tgvnldlkqd ssaqmqsshs nrnqeeflti kkrklsedgv 241 tdgdgkpipe serrphlnef kdldpqfldt nkvfnvfnsa iseegrnrlw llpkninkss 301 ifqiqylier dpflfkffnd lnilietqfn gplhdlvasr nsiernsgis qilkfpsqsi 361 tqtlinkyls titetnsilp ilkpkrllpi veqlfpsnti nkpnskdfet ifqvfsvtnd 421 qllnlgfitl cllilfesln stvliplrdd ehlqlfnvlf nylpllksnl ttlrfeiekr 481 smcnietlrf islwkyyqfv mdtsssssfv idydedmhma cllslnhetq nqshiltwnf 541 ifknycwrhl flgqlpllms epftnstpii dpllnndfel idfevnlmky lqskdqqlsi 601 dkiiqlikll knknievsqg clttpsiinn imdsliyrns mlylnfylll qfetlknyak 661 fneiledfle lsretlffvf snlanikfag heftfinksi vvlqtlvlml lalyqrsfds 721 skrtndanei seqtdihsnn dnskriknkn vihliinkia mllsdytknc kkqnklienl 781 iikiktisky iknleenkvt tsadsnysin ngfsgisaeq liklnhelsk isesliktdf 841 yeqrknstvs ngvlgaaapv dsdansdtfg ltkenfnevf eairs // LOCUS NP_010590 225 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase family protein CPR5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010590 VERSION NP_010590.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180612.3 REFERENCE 1 (residues 1 to 225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 225) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12143. On Jul 30, 2012 this sequence version replaced NP_010590.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..225 /product="peptidylprolyl isomerase family protein CPR5" /EC_number="5.2.1.8" /calculated_mol_wt="25196" Region 34..194 /region_name="cyclophilin" /note="cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug...; cl00197" /db_xref="CDD:469651" Site order(86,88,91..92,94,132..133,142,144,152..153,157) /site_type="active" /db_xref="CDD:238194" CDS 1..225 /gene="CPR5" /locus_tag="YDR304C" /gene_synonym="CYP5" /coded_by="NM_001180612.3:1..678" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276|PMID:8377189|PMID:26928762]" /note="Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the ER; catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER; CPR5 has a paralog, CPR2, that arose from the whole genome duplication" /db_xref="GeneID:851898" /db_xref="SGD:S000002712" ORIGIN 1 mklqffsfit lfaclfttai fakedtaedp eithkvyfdi nhgdkqigri vmglyglttp 61 qtvenfyqlt isrdpkmgyl nsifhrvipn fmiqggdfth rsgiggksif gntfkdenfd 121 vkhdkpgrls manrgkntng sqffittvpc pwldgkhvvf gevldgmdvv hyienvktds 181 rnmpvkevii vesgeletvp ldnkdaaklq eeikaeasea ahdel // LOCUS NP_010591 217 aa linear PLN 30-JUN-2025 DEFINITION bis(5'-adenosyl)-triphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010591 VERSION NP_010591.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180613.1 REFERENCE 1 (residues 1 to 217) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 217) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 217) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 217) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12144. Method: conceptual translation. FEATURES Location/Qualifiers source 1..217 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..217 /product="bis(5'-adenosyl)-triphosphatase" /EC_number="3.6.1.29" /calculated_mol_wt="24653" Region 16..135 /region_name="FHIT" /note="FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; cd01275" /db_xref="CDD:238606" Site order(37,39..40,47,49,96,103,105,109,111) /site_type="active" /note="nucleotide binding site/active site [active]" /db_xref="CDD:238606" Site order(107,109,111..113) /site_type="active" /note="HIT family signature motif [active]" /db_xref="CDD:238606" Site 109 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:238606" CDS 1..217 /gene="HNT2" /locus_tag="YDR305C" /gene_synonym="APH1" /coded_by="NM_001180613.1:1..654" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0016787 hydrolase activity [PMID:12028594]" /experiment="EXISTENCE:direct assay:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:1653209]" /experiment="EXISTENCE:mutant phenotype:GO:0009164 nucleoside catabolic process [PMID:9573184]" /note="Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins" /db_xref="GeneID:851899" /db_xref="SGD:S000002713" ORIGIN 1 milsktkkpk smnkpiyfsk flvteqvfyk skytyalvnl kpivpghvli vplrttvlnl 61 sdltmpesqd yfktlqlihr fikwqykads invaiqdgpe agqsvphlht hiiprykinn 121 vgdliydkld hwdgngtltd wqgrrdeylg vggrqarknn stsatvdgde lsqgpnvlkp 181 dsqrkvralt emkkeaedlq arleefvssd pgltqwl // LOCUS NP_010592 478 aa linear PLN 30-JUN-2025 DEFINITION Pfu1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010592 VERSION NP_010592.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180614.1 REFERENCE 1 (residues 1 to 478) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 478) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 478) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12145. Method: conceptual translation. FEATURES Location/Qualifiers source 1..478 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..478 /product="Pfu1p" /calculated_mol_wt="54306" Region 275..379 /region_name="LRR_5" /note="BspA type Leucine rich repeat region (6 copies); pfam13306" /db_xref="CDD:463839" CDS 1..478 /gene="PFU1" /locus_tag="YDR306C" /coded_by="NM_001180614.1:1..1437" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /note="F-box protein that regulates pheromone-dependent morphogenesis; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain" /db_xref="GeneID:851900" /db_xref="SGD:S000002714" ORIGIN 1 manksrpkki kapyrkyvag egfsstrndn kakeftitip edaelietpq gsyyydetnd 61 tivkltrlsn ekkdkkgrkq spsssstsss kgekngkvie seearmhsvs vkmvlpweiq 121 hriihyldip ekeeklnkta ngkktttgin mnyllvcrnw yamclpklyy apaltsknfn 181 gfvdtiiink kknlghyvfe lnlstilqsg rnsfvskllr rccsnltkfi apqtsfgyap 241 lislkschdl kfldlglvse tvklkelfsa iknftklthl sfprssidcq gfqdiqwpqn 301 lrylklsggi tnefvidtkw pttittlefs ycpqitelsi ysllsqigdn lkhlffhypm 361 pslaensldh vftycanlis lqlmvdycsk wcfsefmlsk lveydrplkt lylecsgslg 421 laskihpddl tiailesrlp clknicvspk lgwnmksdev adlvvsledq dgslylny // LOCUS NP_010593 662 aa linear PLN 30-JUN-2025 DEFINITION putative dolichyl-phosphate-mannose--protein mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010593 VERSION NP_010593.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180615.3 REFERENCE 1 (residues 1 to 662) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 662) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 662) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 662) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12146. On Jul 30, 2012 this sequence version replaced NP_010593.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..662 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..662 /product="putative dolichyl-phosphate-mannose--protein mannosyltransferase" /EC_number="2.4.1.109" /calculated_mol_wt="77439" Region <104..253 /region_name="PMT_2" /note="Dolichyl-phosphate-mannose-protein mannosyltransferase; cl21590" /db_xref="CDD:473917" Region 292..488 /region_name="beta-trefoil_MIR_PMT7-like" /note="MIR domain, beta-trefoil fold, found in Saccharomyces cerevisiae dolichyl-phosphate-mannose--protein mannosyltransferase 7 (PMT7) and similar proteins; cd23286" /db_xref="CDD:467757" Site order(393,454,456,475,480) /site_type="other" /note="putative heterodimer interface [polypeptide binding]" /db_xref="CDD:467757" CDS 1..662 /gene="PMT7" /locus_tag="YDR307W" /coded_by="NM_001180615.3:1..1989" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /note="Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation" /db_xref="GeneID:851902" /db_xref="SGD:S000002715" ORIGIN 1 mkdlrlqgpy rkyipynifq qcgighlktl dyifaflivi tnftliwksh sssfwnrpwd 61 nnseqelsql iqfyldkafy ihelppftiq fysiirrlki aenlryvslf lnsstlgflf 121 litrrincsr lisatgllil snwetfrneg tiisfdslew clfsvviysf isisiaklgt 181 tnwfanvitl sislglaiss kfigivtwaf vilsfvrqfd rlisdvkvtt iqiikfvilc 241 llfvliipgs ifiisysnll snfktdtpqf skymstyfks ylrgpqvqps rlyygstitl 301 rhldsmvgyl ashdisypsd vdeqlvalsf eefaadnewl iehptlnlsf sevyhadqli 361 pvefgqsikl rhkstgkllr astakppise qdydfqisct kdsnyeggmd erwdvllikd 421 einndkkdna ddkyikplqs eirfynngqr cgllghdlrl pewgrfeqev lcmeypvipr 481 ttflidsvql pvdfqvpmie yyigkisssa efnhtlswsq flylfkeyif kqykynyyik 541 ygknkvtfed afavekwpit ldtdspvwfn fawygsllsm iifmcvqckr miswnpwtta 601 epsfsikwev ynefgweciv gwflhfyift msphfnlgkk lyfqsfffsv lcllesldcl 661 ak // LOCUS NP_010594 140 aa linear PLN 30-JUN-2025 DEFINITION Srb7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010594 VERSION NP_010594.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180616.3 REFERENCE 1 (residues 1 to 140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 140) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12147. On Jul 30, 2012 this sequence version replaced NP_010594.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..140 /product="Srb7p" /calculated_mol_wt="15940" Region 3..131 /region_name="Med21" /note="Subunit 21 of Mediator complex; pfam11221" /db_xref="CDD:463241" CDS 1..140 /gene="SRB7" /locus_tag="YDR308C" /gene_synonym="MED21; SSX1" /coded_by="NM_001180616.3:1..423" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:11118219]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:9891034]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:11118219]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11056220]" /experiment="EXISTENCE:physical interaction:GO:0003714 transcription corepressor activity [PMID:11118219]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11118219]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p" /db_xref="GeneID:851903" /db_xref="SGD:S000002716" ORIGIN 1 mtdrltqlqi cldqmteqfc atlnyidknh gferltvnep qmsdkhatvv ppeefsntid 61 elstdiilkt rqinklidsl pgvdvsaeeq lrkidmlqkk lvevedekie aikkkekllr 121 hvdsliedfv dgianskkst // LOCUS NP_010595 383 aa linear PLN 30-JUN-2025 DEFINITION Gic2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010595 VERSION NP_010595.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180617.1 REFERENCE 1 (residues 1 to 383) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 383) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 383) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 383) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12148. Method: conceptual translation. FEATURES Location/Qualifiers source 1..383 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..383 /product="Gic2p" /calculated_mol_wt="42721" Region 132..169 /region_name="CRIB" /note="PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the...; cd00132" /db_xref="CDD:238077" Site order(134,137,140,142,145,163,167) /site_type="other" /note="GTPase interaction site [polypeptide binding]" /db_xref="CDD:238077" CDS 1..383 /gene="GIC2" /locus_tag="YDR309C" /coded_by="NM_001180617.1:1..1152" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9367980]" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:18387956]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:9367980]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9367980]" /experiment="EXISTENCE:genetic interaction:GO:0005886 plasma membrane [PMID:18387956]" /experiment="EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:9367980]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:16371506]" /experiment="EXISTENCE:genetic interaction:GO:0032488 Cdc42 protein signal transduction [PMID:9367979]" /experiment="EXISTENCE:mutant phenotype:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:18387956]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:14734533]" /experiment="EXISTENCE:mutant phenotype:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:22918946]" /experiment="EXISTENCE:physical interaction:GO:0031106 septin ring organization [PMID:16371506]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:9367979|PMID:9367980]" /note="Rho-family GTPase interacting protein and Cdc42p effector; required with Gic1p for cell polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit" /db_xref="GeneID:851904" /db_xref="SGD:S000002717" ORIGIN 1 mtsasitntg netmnlpqmr siwldedeea eklyglqaqq fmgsddeenl gitfinsdkp 61 vlsnkkniel pplspnshps chhrrsnsns akskesssss ssanktnhkk vflklnllkk 121 kllgaqpdir gkgistpfdf qhishadtrn gfqdeqlqep sslsteikdd ytsssskrds 181 kslnkafvte ripanreskl isrshenkts rlsvarsisv tssnyskntq gnnhsingrv 241 vststmatsi feyspnaspk qfknkshalg hrytnstdss essldflkny nfptlledkp 301 ildflprsqr ssayrsllet pnsnkdsaka ffpsrqsplp krrnsiatps pqskfsysds 361 pvnhrksfdd vlysfnqlep lqt // LOCUS NP_010596 1062 aa linear PLN 30-JUN-2025 DEFINITION Sum1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010596 VERSION NP_010596.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180618.1 REFERENCE 1 (residues 1 to 1062) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1062) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1062) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1062) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1062) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1062) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1062) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1062) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1062) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12149. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1062 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1062 /product="Sum1p" /calculated_mol_wt="118070" CDS 1..1062 /gene="SUM1" /locus_tag="YDR310C" /coded_by="NM_001180618.1:1..3189" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12832469]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:12832469]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16077008]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8754829]" /experiment="EXISTENCE:direct assay:GO:0010944 negative regulation of transcription by competitive promoter binding [PMID:12832469]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16077008]" /experiment="EXISTENCE:genetic interaction:GO:0032298 positive regulation of DNA-templated DNA replication initiation [PMID:16077008]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10562556]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:10562556]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:12832469]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16077008]" /experiment="EXISTENCE:mutant phenotype:GO:0032298 positive regulation of DNA-templated DNA replication initiation [PMID:16077008]" /experiment="EXISTENCE:physical interaction:GO:0032298 positive regulation of DNA-templated DNA replication initiation [PMID:16077008]" /note="Transcriptional repressor that regulates middle-sporulation genes; required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint" /db_xref="GeneID:851905" /db_xref="SGD:S000002718" ORIGIN 1 msenttapsd nitneqrlps gpkddvdtla ltsaqnqans lrkldtdana kalpsitdip 61 vsddsdikrq vgsgfgsnpl hikdseafph ssiealkegm dkvtkqcndl ktallskdts 121 ltdsvqdlfn slkvlshnqs vlenklddvm knqvntdilv nnlnerlnkl stmlqntskv 181 nhsnlliens snntssqhnt sssrrgpgrp rkdaststmn klvsnaasvn lksasnqgap 241 fspvnitlpt avvqtskskr yfvepstkqe slllsapsss rddadmslts vpqrtnneng 301 kerpstanss sitptpvtpn nliqikrkrg rppkkrtvet misnstdtid ksdasnrikn 361 eipinsllps skfhqipssp snpvsqpapv rtsrsatqei dikslelasl istngdpnae 421 dsnttdtvhn nvegkvnvee nktekekiit iksssensgn nttnnnntdn vikfsansdi 481 nsdirrlmvn dqfslsydas gnitvklppv sspaaataaa aaavtsemnr qqreldkrrd 541 srekmlvnmk yndrdkaksf mesnkkllka mkeeerrkrm tsiihdnhln lnlneistrs 601 kiksaekptt kgssmspkpr sasisgisdh qqegyqpleq eklvdidneg snansdslkm 661 gltisaadtv hkvgiqsmln sgeeaitken aeyerktpgd eetttfvple nsqpsdtirk 721 rtagddgald qtentsispk krrtedhtkg eedegergvg nsgtlatven vsgdisadls 781 kgtssihndt esandssngn gnlglgtesr ntlltatpie licregffyr rdipdvpitt 841 gaylefkfka keeelinssi needyaaksk hekmnahffk pdiqeetela feilskttlt 901 ekyvnsleyf lmefrwenkl vglglklres krtwqrrkal falfefwrdq srdkrrfhny 961 tilhavkeme nyrifinrsv swfynhitll kmilydlcdn vttqwrewmf phnetlpalg 1021 qdginednln etidnmlifd flddgsennq vkysriippd ir // LOCUS NP_010597 642 aa linear PLN 30-JUN-2025 DEFINITION TFIIH/NER complex subunit TFB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010597 VERSION NP_010597.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180619.3 REFERENCE 1 (residues 1 to 642) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 642) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 642) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 642) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12150. On Jul 30, 2012 this sequence version replaced NP_010597.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..642 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..642 /product="TFIIH/NER complex subunit TFB1" /calculated_mol_wt="72764" Region 9..105 /region_name="PH_TFIIH" /note="TFIIH p62 subunit, N-terminal domain; pfam08567" /db_xref="CDD:462521" Region 177..225 /region_name="BSD" /note="BSD domain; pfam03909" /db_xref="CDD:461089" Region 245..295 /region_name="BSD" /note="domain in transcription factors and synapse-associated proteins; smart00751" /db_xref="CDD:128990" CDS 1..642 /gene="TFB1" /locus_tag="YDR311W" /coded_by="NM_001180619.3:1..1929" /experiment="EXISTENCE:direct assay:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:8855246]" /experiment="EXISTENCE:direct assay:GO:0000439 transcription factor TFIIH core complex [PMID:19818408|PMID:14500720]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:27381459|PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:15909982]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:15909982]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:7891722]" /experiment="EXISTENCE:mutant phenotype:GO:0006360 transcription by RNA polymerase I [PMID:12015980]" /note="Subunit of TFIIH and nucleotide excision repair factor 3 complexes; required for nucleotide excision repair, target for transcriptional activators; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:851906" /db_xref="SGD:S000002719" ORIGIN 1 mshsgaaife kvsgiiaine dvspaeltwr stdgdkvhtv vlstidklqa tpassekmml 61 rligkvdesk krkdnegnev vpkpqrhmfs fnnrtvmdni kmtlqqiisr ykdadiyeek 121 rrreesaqht etpmssssvt agtptphldt pqlnngapli ntaklddsls keklltnlkl 181 qqsllkgnkv lmkvfqetvi naglppsefw stripllraf alstsqkvgp ynvlstikpv 241 assenkvnvn lsrekilnif enypivkkay tdnvpknfke pefwarffss klfrklrgek 301 imqndrgdvi idryltldqe fdrkdddmll hpvkkiidld gniqddpvvr gnrpdftmqp 361 gvdingnsdg tvdilkgmnr lsekmimalk neysrtnlqn ksnitndeed edndernelk 421 iddlnesykt nyaiihlkrn ahekttdnda kssadsikna dlkvsnqqml qqlslvmdnl 481 inkldlnqvv pnnevsnkin krvitaikin akqakhnnvn salgsfvdnt sqanelevks 541 tlpidllesc rmlhttccef lkhfyihfqs geqkqastvk klynhlkdci eklnelfqdv 601 lngdgesmsn tctaylkpvl nsitlathky deyfneynnn sn // LOCUS NP_010598 453 aa linear PLN 30-JUN-2025 DEFINITION rRNA-binding ribosome biosynthesis protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010598 VERSION NP_010598.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180620.3 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12151. On Jul 30, 2012 this sequence version replaced NP_010598.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..453 /product="rRNA-binding ribosome biosynthesis protein" /calculated_mol_wt="51725" Region 26..220 /region_name="Brix" /note="The Brix domain is found in a number of eukaryotic proteins; smart00879" /db_xref="CDD:214879" CDS 1..453 /gene="SSF2" /locus_tag="YDR312W" /coded_by="NM_001180620.3:1..1362" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12702244]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:11864606]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:11864606]" /note="Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication" /db_xref="GeneID:851907" /db_xref="SGD:S000002720" ORIGIN 1 makrrqkkrt haqitpeqer dipksmvirv gqtslanhsl nqlvkdfrqi mqphtavklk 61 erksnklkdf vvmcgplgvt hlfmftqsek tgnvslkiar tpqgptvtfq vldyslgrdi 121 kkflkrpksl nnddvlnppl lvlngfstsk rsdeddqdvn vekvivsmfq nifpplnpar 181 tslnsikrif minkdretge ismrhyfidi reveisrnlk rlykaknnls ktvpnlhrke 241 disslildhd lgaytsesei eddaivrvvd nqdvkakhsq tslsqktpvk mtdneerekg 301 ieeedvemee pkpsensqpt prkkaiklte lgprltlklv kiedgicsgk vlhhefvqks 361 seeikalekr haakmrlkeq rrkeqeenia kkkavkdakk qrklerrkar aeeqgegqgk 421 dgamsddgss ssedehysdv pedldsdlfs eve // LOCUS NP_010599 286 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010599 VERSION NP_010599.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180621.1 REFERENCE 1 (residues 1 to 286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 286) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12152. Method: conceptual translation. FEATURES Location/Qualifiers source 1..286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..286 /product="phosphatidylinositol-3-phosphate-binding ubiquitin-protein ligase" /EC_number="2.3.2.27" /calculated_mol_wt="32544" Region 12..89 /region_name="FYVE" /note="Protein present in Fab1, YOTB, Vac1, and EEA1; smart00064" /db_xref="CDD:214499" Region 224..260 /region_name="mRING-CH-C4HC2H_ZNRF" /note="Modified RING-CH finger, H2 subclass (C4HC2H-type), found in the ZNRF family; cd16489" /db_xref="CDD:438152" CDS 1..286 /gene="PIB1" /locus_tag="YDR313C" /coded_by="NM_001180621.1:1..861" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11526110]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:11526110]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:11526110]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:11526110|PMID:31604822]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:9702203]" /experiment="EXISTENCE:mutant phenotype:GO:0031647 regulation of protein stability [PMID:31604822]" /experiment="EXISTENCE:mutant phenotype:GO:0042176 regulation of protein catabolic process [PMID:31604822]" /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:31604822]" /note="RING-type ubiquitin ligase of the endosomal and vacuolar membranes; binds phosphatidylinositol 3-phosphate; contains a FYVE finger domain" /db_xref="GeneID:851908" /db_xref="SGD:S000002721" ORIGIN 1 mvikedcinn larwqadeea hscfqcktnf sflvrrhhcr ccgrifcssc tenfvnynkk 61 rvhalqkkns dvesppyrtc necydnllhl nllvsstnrd vrlsqtsvpp nalalsapds 121 ntdedaeile dsvdqsgtac rseessqnee dhfcpicnsd ltqfpdeeet rkhvedciqr 181 aenaqqhtnt sdaaddsvke spafqnrmlv ykispnttdn aikecpicfe nmepgekvgr 241 leclcvfhyk ciknwfhkra qmtaaqkgng hafvkrnfcp fhdavf // LOCUS NP_010600 692 aa linear PLN 30-JUN-2025 DEFINITION Rad34p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010600 VERSION NP_010600.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180622.1 REFERENCE 1 (residues 1 to 692) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 692) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 692) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 692) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12153. Method: conceptual translation. FEATURES Location/Qualifiers source 1..692 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..692 /product="Rad34p" /calculated_mol_wt="81912" Region 2..682 /region_name="RAD4" /note="DNA repair protein RAD4 [DNA replication, recombination, and repair]; COG5535" /db_xref="CDD:227822" CDS 1..692 /gene="RAD34" /locus_tag="YDR314C" /coded_by="NM_001180622.1:1..2079" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:15916602|PMID:18936173]" /note="Protein involved in nucleotide excision repair (NER); homologous to RAD4" /db_xref="GeneID:851909" /db_xref="SGD:S000002722" ORIGIN 1 makrllessq ndqanrknsk iekkevsfye eeetddsfds fyqdeeddls didweevsld 61 gsltvtfgni rrdrekvsky krkhnkkafn yqrlkyglhl imipfmlfll ksrmkwidde 121 rlnrrlrrsv pkligkkfkd wdvrdpafkm dslrtlllgl vlwfrsnykm nsngirqnfn 181 rlqylikyad nqnensises tykkvlenqq efygnrplin hgvedirkma krkmanrdil 241 tlfffiilen vlpgpkklyl cfalplhdyd ircnkvkwqi ehgigkvpnr fdsdliqpyf 301 wielevptls dgelyiidpi ahlgeremvl ktredqfvpt yqpsvdmkyn lnqkfhyvvr 361 inhaekvlqd vspryvpnvc yryfelsess pilkskhyts yqylskwlkv lnkkkasvhh 421 yaimkkialt nftlpksvte ikrtdnfvip sllksnevlk acakqaatft kgdnsqepif 481 wrrdviqlks kqhwailgrs ilpnaqplkr kkylpmrerm vrnldkyvik elfsyeqtmk 541 spkypstycd hlgqehvitd lshyknkfgn ieiysketkp dgfeliplsk evdikclike 601 ynkgkrkmqk ikyldvvsgf dfkqkkghai pkiesilvke tdykavqllk qqtkvllgls 661 fwdillrklr vndrlnaeyg nvgnneetld dh // LOCUS NP_010601 281 aa linear PLN 30-JUN-2025 DEFINITION inositol pentakisphosphate 2-kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010601 VERSION NP_010601.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180623.3 REFERENCE 1 (residues 1 to 281) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 281) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 281) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 281) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12154. On Jul 30, 2012 this sequence version replaced NP_010601.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..281 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..281 /product="inositol pentakisphosphate 2-kinase" /EC_number="2.7.1.158" /calculated_mol_wt="32787" Region 4..262 /region_name="Ins_P5_2-kin" /note="Inositol-pentakisphosphate 2-kinase; pfam06090" /db_xref="CDD:461826" CDS 1..281 /gene="IPK1" /locus_tag="YDR315C" /gene_synonym="GSL1" /coded_by="NM_001180623.3:1..846" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10390371]" /experiment="EXISTENCE:direct assay:GO:0032958 inositol phosphate biosynthetic process [PMID:10960485]" /experiment="EXISTENCE:direct assay:GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity [PMID:10960485]" /experiment="EXISTENCE:mutant phenotype:GO:0032958 inositol phosphate biosynthetic process [PMID:10960485|PMID:10390371]" /experiment="EXISTENCE:mutant phenotype:GO:0035299 inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity [PMID:10960485]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:17660569]" /note="Inositol 1,3,4,5,6-pentakisphosphate 2-kinase; nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable; human IPPK can complement ipk1 null mutant" /db_xref="GeneID:851910" /db_xref="SGD:S000002723" ORIGIN 1 mqvigrggan ilidygdptw lwrccirwpd llssnnsyti knisyikdyv epllhgllcp 61 mylidvdiea irpilsdfil nlddkvvkvi kiknltnnts nlilnnhflk sycsqnlqtv 121 ilelkpkwly ydtdycrnct hnafkgrgtk ycynqllmnp ahlelifgec nifpvkfkda 181 mheylrndnn ifkilydlqk kltknttpis diksindvnd ehlllmtlrd vtcfiewnsa 241 enalhvniid vdlkpkekwt hwtktysqlt ssqkiyhtsn k // LOCUS NP_010602 471 aa linear PLN 30-JUN-2025 DEFINITION putative RNA methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010602 VERSION NP_010602.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180624.3 REFERENCE 1 (residues 1 to 471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 471) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12155. On Jul 30, 2012 this sequence version replaced NP_010602.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..471 /product="putative RNA methyltransferase" /calculated_mol_wt="55458" Region 210..374 /region_name="UbiE" /note="Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; COG2226" /db_xref="CDD:441828" CDS 1..471 /gene="OMS1" /locus_tag="YDR316W" /coded_by="NM_001180624.3:1..1416" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:15355998]" /note="Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif and is predicted to be an RNA methyltransferase; multicopy suppressor of respiratory defects caused by OXA1 mutations" /db_xref="GeneID:851911" /db_xref="SGD:S000002724" ORIGIN 1 mivfrrfptc llhhirqpas rslllesqrr slsftsykyn sshidddksk kklknvfqmn 61 snrvirkqkt keelakerfe eqlrspnrfv rwgaiarsek fskgmtkymi gayvifliyg 121 lfftkklfak dkelerllkk qeegnaneye alrikelkgk lrrrdelkle eykkmqeegi 181 enfddirvqn fdqnklneqi lpardttnfy qekaneydka inmeervifl gkrrkwlmkh 241 cqgdvlevsc gtgrnikyld msrinsitfl dssenmmeit hkkfrekfpk ykkvafvvgk 301 aenlvdlaek gkpsleneke nqvkydtive afglcshedp vkalnnfgkl lkpdgriill 361 ehgrgqydfi nkildnraer rlntwgcrwn ldlgevldds dlelveekrt hlgttwciva 421 krkgdvkkkd elgfvekylq ssirkrmesf ekkddmaskk elepvppvsk s // LOCUS NP_058151 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058151 VERSION NP_058151.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184424.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12157. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..440 /product="gag protein" /calculated_mol_wt="48998" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YDR316W-A" /coded_by="NM_001184424.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:851913" /db_xref="SGD:S000007398" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_058150 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058150 VERSION NP_058150.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184425.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12156. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198397" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YDR316W-B" /coded_by="join(NM_001184425.2:1..1305, NM_001184425.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:851914" /db_xref="SGD:S000007399" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp nsapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmntwdtd kyydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlshlv qelnkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_010603 414 aa linear PLN 30-JUN-2025 DEFINITION Him1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010603 VERSION NP_010603.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180625.3 REFERENCE 1 (residues 1 to 414) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 414) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 414) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 414) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12158. On Jul 30, 2012 this sequence version replaced NP_010603.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..414 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..414 /product="Him1p" /calculated_mol_wt="47206" Region 168..336 /region_name="HIM1" /note="pfam08732" /db_xref="CDD:400878" CDS 1..414 /gene="HIM1" /locus_tag="YDR317W" /coded_by="NM_001180625.3:1..1245" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:15885712]" /note="hypothetical protein involved in DNA repair" /db_xref="GeneID:851915" /db_xref="SGD:S000002725" ORIGIN 1 msysvntftd yvllfgsssl vgkgilenll dinlyiknvs dlqgkldsls eikgnvvlnk 61 hvfcvnrrci neeksfmkti dyinmrsvtw qggryylrsr kekdtekvps spntfcydnf 121 eegfikntpe ergkdgysfv ynqkqfsytl hyacgkekgi eiicnftvtq liiprsetwp 181 kllprifsgt qklekfdidn knyvpgrslp slcdistmvc slgstsarvr rtqvpssfad 241 yylpfnlaqe ftnttnkrlv vttafnndfl sktfeyfrik aklendldea lpnklkelvi 301 lrpgpmcgqh gnpinvelgk enstflekif yyphyllvyk kkyisearri glrtklseii 361 assiyrmpgs allgyavpvs kvsyvaslma ierkskeagp klevissyqi dmiv // LOCUS NP_010604 368 aa linear PLN 30-JUN-2025 DEFINITION Mcm21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010604 VERSION NP_010604.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180626.3 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12159. On Jul 30, 2012 this sequence version replaced NP_010604.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..368 /product="Mcm21p" /calculated_mol_wt="42840" Region 2..>56 /region_name="CwlO1" /note="Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown]; COG3883" /db_xref="CDD:443091" Region 161..271 /region_name="DRWD-N_Mcm21" /note="N-terminal double-RWD domain of minichromosome maintenance protein 21 (MCM21) and related proteins; cd23830" /db_xref="CDD:467664" Site order(163,165..167,169..170,172..181,200..202,205,207..209, 211,214..216,218..219,221,223,233,236..239,262,265..266, 269) /site_type="other" /note="Ctf19 interface [polypeptide binding]" /db_xref="CDD:467664" Region 276..363 /region_name="DRWD-C_Mcm21" /note="C-terminal double-RWD domain of minichromosome maintenance protein 21 (MCM21) and related proteins; cd23834" /db_xref="CDD:467667" Site order(276,280,283,287,353) /site_type="other" /note="Ctf19 interface [polypeptide binding]" /db_xref="CDD:467667" CDS 1..368 /gene="MCM21" /locus_tag="YDR318W" /gene_synonym="CTF5" /coded_by="NM_001180626.3:1..1107" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:10323865]" /experiment="EXISTENCE:direct assay:GO:0000817 COMA complex [PMID:14633972]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /experiment="EXISTENCE:mutant phenotype:GO:0071459 protein localization to chromosome, centromeric region [PMID:26653857]" /experiment="EXISTENCE:mutant phenotype:GO:1905262 negative regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [PMID:26653857]" /note="Component of the kinetochore sub-complex COMA; COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) bridges kinetochore subunits in contact with centromeric DNA with subunits bound to microtubules during kinetochore assembly; involved in minichromosome maintenance; modified by sumoylation; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-O" /db_xref="GeneID:851916" /db_xref="SGD:S000002726" ORIGIN 1 msriddlqqd iesllseins leesreklka kikdkrknee sanpivqefe dlfdqfpqln 61 nflfnehpel eetddkdisr aqadipatpi pyepkkrakl eneeilpeqe wvlktqpmvq 121 hqmfdpgvad lldtdiltsp skrkrklkid distsdrsel edyivlenvy rmfgitffpl 181 vdpidlkikd asgeifvdre mlgirlevfs ertsqfekph yvllkkriks nswflfkhti 241 psfidvqgif ddtngglvis hddaylfakr vflqlvevqk rrqifkdlea kkiihdldld 301 lessmvsffv kdikvelfvk qneivscsil ddihdfsqnn kskweiallg slddlelkln 361 hsfatifk // LOCUS NP_010605 274 aa linear PLN 30-JUN-2025 DEFINITION Yft2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010605 VERSION NP_010605.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180627.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12160. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..274 /product="Yft2p" /calculated_mol_wt="31880" Region 48..259 /region_name="Scs3p" /note="Inositol phospholipid synthesis and fat-storage-inducing TM; pfam10261" /db_xref="CDD:402051" CDS 1..274 /gene="YFT2" /locus_tag="YDR319C" /gene_synonym="FIT2A" /coded_by="NM_001180627.1:1..825" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:29526591]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:22927826]" /note="Protein needed for ER membrane biosynthesis in response to ER stress; member of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; homologous to human FIT2/FITM2, a fatty acyl-CoA diphosphatase; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens" /db_xref="GeneID:851917" /db_xref="SGD:S000002727" ORIGIN 1 mirqlnywsr kayliypfqv fvgallsivv ssetlnhqke tcallkssni fnvifaykan 61 qlwpflffsl aflqiyfhyl armdilplpi sstetsssyl tytnhwpllk nriisimitq 121 yackfvlkyl llflnfqfid hvfiwtggec ssgskttsae kcrlengkwd ggfdisghfc 181 flvsismilw melhlfsrfv qaedmfwvvn kwvraclaiv cavlviwici lwvtaiyyht 241 ilekvlgclm gficpvfiyh ilpkigilhn ylyl // LOCUS NP_010606 668 aa linear PLN 30-JUN-2025 DEFINITION auxilin-like protein SWA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010606 VERSION NP_010606.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180628.1 REFERENCE 1 (residues 1 to 668) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 668) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 668) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 668) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12161. Method: conceptual translation. FEATURES Location/Qualifiers source 1..668 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..668 /product="auxilin-like protein SWA2" /calculated_mol_wt="74889" Region 138..181 /region_name="Ubiq-assoc" /note="Ubiquitin-associated; pfam09145" /db_xref="CDD:401184" Region 374..402 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(375,378..379,382..383,385,409,416..417,420..421, 423..424,468,471..472,475..476,479) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 383..496 /region_name="CpoB" /note="Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning]; COG1729" /db_xref="CDD:441335" Region 407..441 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 467..495 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..668 /gene="SWA2" /locus_tag="YDR320C" /gene_synonym="AUX1; BUD24" /coded_by="NM_001180628.1:1..2007" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11553703]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:16687570]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:18948116]" /experiment="EXISTENCE:direct assay:GO:0072318 clathrin coat disassembly [PMID:23913685]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:11553703]" /experiment="EXISTENCE:mutant phenotype:GO:0072318 clathrin coat disassembly [PMID:11146663]" /note="Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles; required for propagation of [URE3] prion variant" /db_xref="GeneID:851918" /db_xref="SGD:S000002728" ORIGIN 1 msdpfahllt slknkdsasa skettpqssn spsitgsava dvartdkspn dslhsisapp 61 lipspkvdfs applvptnst tksntanntp psalantddd fnqlfgmgtv tttdtiqkpd 121 edyygskedh lyngddalvd evkdmeiarl mslglsieea tefyendvty eryleilksk 181 qkerndlair kkesgikmek sglsnivgtd snnlfsmatd ffnkgkklvd qwtsfppean 241 drlnnyskth dkvedydlpq vndspnrilf ednevvenlp padnpdqdll tdfetkidit 301 krtapdvshs ssptsgilie ensrrnepli edslldfseg nltnsksned stlfnensnt 361 dstipisdie lsgynefkak gtslfkngdy inslqeyeks lntlplnhpl riialsniia 421 sqlkigeysk sienssmale lfpsskakwk nkisnsdper sfndiwpkim irraesfehl 481 esfkkalety qelikknffd dkimqgkrrc qdfinpppvk ksmpvkkktt ttspatkkqn 541 ltasssnspi svdstseikk relenaklal ydkvfekiss wkdgkdddir hllanlssll 601 twcnwkdvsm qdlvmpkrvk itymkavakt hpdkipesls lenkmiaeni fstlsiawdk 661 fklqndin // LOCUS NP_710144 72 aa linear PLN 30-JUN-2025 DEFINITION Dad4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_710144 VERSION NP_710144.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184470.3 REFERENCE 1 (residues 1 to 72) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 72) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 72) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 72) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12162. On Jul 30, 2012 this sequence version replaced NP_710144.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..72 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..72 /product="Dad4p" /calculated_mol_wt="8024" Region 1..71 /region_name="DASH_Dad4" /note="DASH complex subunit Dad4; pfam08650" /db_xref="CDD:430130" CDS 1..72 /gene="DAD4" /locus_tag="YDR320C-A" /gene_synonym="HSK2" /coded_by="NM_001184470.3:1..219" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15664196|PMID:15640796]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:20479465|PMID:17620411]" /note="Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" /db_xref="GeneID:851919" /db_xref="SGD:S000007604" ORIGIN 1 menpheqvqa nilsriignv krlnesvail nqelvtinnr nknleimgai cdnyhssvqf 61 nleatnnkkp pl // LOCUS NP_010607 381 aa linear PLN 30-JUN-2025 DEFINITION asparaginase ASP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010607 VERSION NP_010607.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180629.3 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12163. On Jul 30, 2012 this sequence version replaced NP_010607.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..381 /product="asparaginase ASP1" /EC_number="3.5.1.1" /calculated_mol_wt="41264" Region 30..378 /region_name="asnASE_II" /note="L-asparaginase, type II; TIGR00520" /db_xref="CDD:273115" Site order(63..64,109..111,140..142,167,215,301) /site_type="active" /db_xref="CDD:199208" Site order(64,111..115,118,142,146,169,174..176,179..180, 204..205,209,211,215..218,220,229..231,233,235,240, 242..244,246..247,270,272,274,278,280,287,289,297..299,301, 303,321..322,329..330) /site_type="other" /note="homotetramer interface [polypeptide binding]" /db_xref="CDD:199208" Site order(111..115,118,142..143,145..147,215..219,268..270,272, 274,278,280..281,284,287,289,297..299,301..303,321..323, 326..327,351..352,355) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:199208" CDS 1..381 /gene="ASP1" /locus_tag="YDR321W" /coded_by="NM_001180629.3:1..1146" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:323221|PMID:17537182]" /experiment="EXISTENCE:direct assay:GO:0004067 asparaginase activity [PMID:27824095|PMID:17537182]" /experiment="EXISTENCE:mutant phenotype:GO:0004067 asparaginase activity [PMID:17537182|PMID:27824095]" /experiment="EXISTENCE:mutant phenotype:GO:0006530 L-asparagine catabolic process [PMID:323221]" /note="Cytosolic L-asparaginase, involved in asparagine catabolism; catalyzes hydrolysis of L-asparagine to aspartic acid and ammonia; important enzyme for the treatment of acute lymphoblastic leukemia; has low glutaminase activity and dependence; synthesized constitutively" /db_xref="GeneID:851920" /db_xref="SGD:S000002729" ORIGIN 1 mksdsveitt icpdvensqf vvqsncpeti peilksqnaa vngsgiacqq rslprikilg 61 tggtiaskai dssqtagyhv dltiqdllda ipdiskvcdi eyeqlcnvds kdinedilyk 121 iykgvseslq afdgivithg tdtlsetaff iestidagdv pivfvgsmrp stsvsadgpm 181 nlyqaicias npksrgrgvl vslndqissg yyitktnans ldsfnvrqgy lgnfvnneih 241 yyyppvkpqg chkfklrvdg khfklpevci lyahqafppa ivnlvadkyd givlatmgag 301 slpeevnetc mklslpivys krsmdgmvpi anvpkkgske dnliasgyls peksrillql 361 clagnytlee ikhvftgvyg g // LOCUS NP_010608 367 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL38 MRPL35 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010608 VERSION NP_010608.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180630.1 REFERENCE 1 (residues 1 to 367) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 367) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 367) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 367) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12164. Method: conceptual translation. FEATURES Location/Qualifiers source 1..367 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..367 /product="mitochondrial 54S ribosomal protein mL38 MRPL35" /calculated_mol_wt="42694" Region 178..341 /region_name="PEBP_euk" /note="PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; cd00866" /db_xref="CDD:176644" Site order(230,244,246,278..281,287,289) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:176644" CDS 1..367 /gene="MRPL35" /locus_tag="YDR322W" /gene_synonym="mL38" /coded_by="NM_001180630.1:1..1104" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:28931599]" /note="Mitochondrial ribosomal protein of the large subunit; involved together with Mrp7p in assembly of cytochrome c oxidase" /db_xref="GeneID:851921" /db_xref="SGD:S000002730" ORIGIN 1 mlrrsihttk ilqkpnatsh iwsdfttrps slsiqsskvk nylfqkkasl dppsisrrsn 61 rikysppehi deifrmsydf leqrsskfye lanktknplk kdallikaei nnpevqynfq 121 fnnklnnvkd iidydvpvyr hlgkqhwesy gqmllmqrle tlaaipdtlp tlvpraevni 181 kfpfstgvnk wiepgeflss nvtsmrpifk iqeyelvnve kqlytvlivn pdvpdlsnds 241 fktalcyglv ninltyndnl idprkfhssn iiadylppvp eknagkqrfv vwvfrqplie 301 dkqgpnmlei drkelsrddf dirqftkkyn ltaigahiwr sewdakvaav rekyglppgr 361 vfsrvrr // LOCUS NP_010609 96 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit e [Saccharomyces cerevisiae S288C]. ACCESSION NP_010609 VERSION NP_010609.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184348.1 REFERENCE 1 (residues 1 to 96) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 96) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 96) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 96) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12165. Method: conceptual translation. FEATURES Location/Qualifiers source 1..96 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..96 /product="F1F0 ATP synthase subunit e" /calculated_mol_wt="10744" Region 3..70 /region_name="ATP-synt_E" /note="ATP synthase E chain; pfam05680" /db_xref="CDD:368558" CDS 1..96 /gene="TIM11" /locus_tag="YDR322C-A" /gene_synonym="ATP21" /coded_by="NM_001184348.1:1..291" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:9857174]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:9857174]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:19528297]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:9857174]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:16551625|PMID:20219971]" /note="Subunit e of mitochondrial F1F0-ATPase; ATPase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase, which in turn determines the shape of inner membrane cristae" /db_xref="GeneID:851922" /db_xref="SGD:S000007255" ORIGIN 1 mstvnvlrys alglglffgf rndmilkcna kkkeeqaqye eklklveeak keyaklhpvv 61 tpkdvpanas fnledpnidf ervilnaves lkeast // LOCUS NP_010610 515 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol-3-phosphate binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010610 VERSION NP_010610.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180631.3 REFERENCE 1 (residues 1 to 515) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 515) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 515) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 515) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12166. On Jul 30, 2012 this sequence version replaced NP_010610.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..515 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..515 /product="phosphatidylinositol-3-phosphate binding protein" /calculated_mol_wt="59313" Region 65..141 /region_name="FYVE1_Vac1p_like" /note="FYVE-related domain 1 found in yeast protein VAC1 (Vac1p) and similar proteins; cd15761" /db_xref="CDD:277300" Region 211..293 /region_name="FYVE2_Vac1p_like" /note="FYVE domain 2 found in yeast protein VAC1 (Vac1p) and similar proteins; cd15737" /db_xref="CDD:277276" Site order(212,215,233..238,240..241,287..289) /site_type="other" /note="putative phosphatidylinositol 3-phosphate binding site [chemical binding]" /db_xref="CDD:277276" Region <423..>509 /region_name="COG2433" /note="Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only]" /db_xref="CDD:441980" Region 467..502 /region_name="Rbsn" /note="Rabenosyn Rab binding domain; pfam11464" /db_xref="CDD:463283" CDS 1..515 /gene="PEP7" /locus_tag="YDR323C" /gene_synonym="VAC1; VPL21; VPS19; VPT19" /coded_by="NM_001180631.3:1..1548" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9168472|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0010009 cytoplasmic side of endosome membrane [PMID:9168472]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:9702203]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:9335586]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:9168472]" /experiment="EXISTENCE:mutant phenotype:GO:0006904 vesicle docking involved in exocytosis [PMID:9168472]" /experiment="EXISTENCE:mutant phenotype:GO:0006906 vesicle fusion [PMID:9168472]" /experiment="EXISTENCE:physical interaction:GO:0006896 Golgi to vacuole transport [PMID:10021387]" /note="Adaptor protein involved in vesicle-mediated vacuolar protein sorting; multivalent adaptor protein; facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance" /db_xref="GeneID:851923" /db_xref="SGD:S000002731" ORIGIN 1 mdlenvscpi clrkfdnlqa lnahldvehg fndnedslgs ndsrlvngkq kkarsvdssa 61 qklkrshwek fkkgksccht cgrtlnnnig aincrkcgkl ycrrhlpnmi klnlsaqydp 121 rngkwyncch dcfvtkpgyn dygevidltp effkvrnikr edknlrllql enrfvrlvdg 181 litlyntysr siihnlkmns emsklertvt pwrddrsvlf cnicsepfgl llrkhhcrlc 241 gmvvcddanr ncsneisigy lmsaasdlpf eyniqkddll hipisirlcs hcidmlfigr 301 kfnkdvrmpl sgifakydsm qniskvidsl lpifedslns lkvetakdse ntldpknlnd 361 larlrhklln sfnlyntltr qllsvepqsh lerqlqnsik iasaayinek ilplkslpai 421 lnpeghktne dgqkaepevk klsqlmienl tikevkelre elmvlkeqsy liestiqdyk 481 kqrrleeivt lnknleelhs rihtvqsklg dhgfn // LOCUS NP_010611 776 aa linear PLN 30-JUN-2025 DEFINITION small subunit rRNA maturation protein UTP4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010611 VERSION NP_010611.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180632.3 REFERENCE 1 (residues 1 to 776) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 776) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 776) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 776) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 776) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 776) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 776) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 776) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 776) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12167. On Jul 30, 2012 this sequence version replaced NP_010611.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..776 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..776 /product="small subunit rRNA maturation protein UTP4" /calculated_mol_wt="87671" Region <43..356 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 58..94 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 99..138 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 145..180 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 190..226 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 241..267 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 272..>443 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 330..370 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 378..423 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 430..466 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..776 /gene="UTP4" /locus_tag="YDR324C" /coded_by="NM_001180632.3:1..2331" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]" /note="Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript; Small Subunit processome is also known as SSU processome" /db_xref="GeneID:851924" /db_xref="SGD:S000002732" ORIGIN 1 msssllsvlk eksrslkirn kpvkmtsqer mivhrcrfvd ftpatitsla fshksninkl 61 tpsdlrlaig rsngnieiwn prnnwfqemv ieggkdrsie glcwsnvnge slrlfsiggs 121 tvvtewdlat glplrnydcn sgviwsisin dsqdklsvgc dngtvvlidi sggpgvlehd 181 tilmrqearv ltlawkkddf viggcsdgri riwsaqknde nmgrllhtmk vdkakkestl 241 vwsviylprt dqiasgdstg sikfwdfqfa tlnqsfkahd advlclttdt dnnyvfsagv 301 drkifqfsqn tnksqknnrw vnssnrllhg ndiraicayq skgadflvsg gvektlvins 361 ltsfsngnyr kmptvepysk nvlvnkeqrl vvswsestvk iwtmgtdsst eqnyklvckl 421 tlkddqnist cslspdgqvl vvgrpsttkv fhlqpvgnkl kvtkldndll lrtstklvkf 481 idnskivics ceddvfivdl eseedekpqe vellevtstk ssikvpyinr inhlevdqni 541 avisrgcgvv dildlkaris kplarlnnfi tavhintsrk svvvitadnk iyefnmnlns 601 eaenedsesv ltqwsknntd nlpkewktlk encvgifsdi enssrlwfwg atwisridfd 661 vdfpinkrrk qkkrtheglt itdesnfmnd eeddedddid meisenlnvl lnqgnkikst 721 dvqrneessg hffftdkykp llfvdlissn elaiiernpl tfhskqkafi qpklvf // LOCUS NP_010612 1035 aa linear PLN 30-JUN-2025 DEFINITION condensin subunit YCG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010612 VERSION NP_010612.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180633.1 REFERENCE 1 (residues 1 to 1035) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1035) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1035) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1035) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12168. On Jan 2, 2003 this sequence version replaced NP_010612.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1035 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1035 /product="condensin subunit YCG1" /calculated_mol_wt="117721" Region 5..1033 /region_name="YCG1" /note="Chromosome condensation complex Condensin, subunit G [Chromatin structure and dynamics / Cell division and chromosome partitioning]; COG5218" /db_xref="CDD:227543" Region 118..146 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(135..136,139,142..143,146,176..177,180,183..184,187, 224..225,228,231..232,257..258,261,264..265) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 158..196 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 205..232 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..1035 /gene="YCG1" /locus_tag="YDR325W" /gene_synonym="TIE1; YCS5" /coded_by="NM_001180633.1:1..3108" /experiment="EXISTENCE:direct assay:GO:0000796 condensin complex [PMID:10811823]" /experiment="EXISTENCE:genetic interaction:GO:0003682 chromatin binding [PMID:11864994]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:11864994]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:11864994]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:14662740]" /experiment="EXISTENCE:mutant phenotype:GO:0010032 meiotic chromosome condensation [PMID:14662740]" /experiment="EXISTENCE:mutant phenotype:GO:0051307 meiotic chromosome separation [PMID:14662740]" /experiment="EXISTENCE:mutant phenotype:GO:0070058 tRNA gene clustering [PMID:18708579]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:18708580]" /experiment="EXISTENCE:mutant phenotype:GO:1903342 negative regulation of meiotic DNA double-strand break formation [PMID:25103240]" /note="Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding by the complex; required for tRNA genes clustering at the nucleolus; required for replication slow zone breakage following Mec1p inactivation; transcription is cell cycle regulated, peaking in mitosis and declining in G1; protein is constitutively degraded by the proteasome; rate limiting for condensin recruitment to chromatin" /db_xref="GeneID:851925" /db_xref="SGD:S000002733" ORIGIN 1 mqdpdgidin tkifnsvaev fqkaqgsyag hrkhiavlkk iqskaveqgy edafnfwfdk 61 lvtkilplkk neiigdrivk lvaafiasle relilakkqn ykltndeegi fsrfvdqfir 121 hvlrgvespd knvrfrvlql lavimdnige ideslfnlli lslnkriydr eptvriqavf 181 cltkfqdeeq tehltelsdn eenfeatrtl vasiqndpsa evrraamlnl indnntrpyi 241 lerardvniv nrrlvysril ksmgrkcfdd iephifdqli ewgledrels vrnackrlia 301 hdwlnaldgd liellekldv srssvcvkai ealfqsrpdi lskikfpesi wkdftveiaf 361 lfraiylycl dnnitemlee nfpeasklse hlnhyillry hhndisndsq shfdyntlef 421 iieqlsiaae rydysdevgr rsmltvvrnm lalttlsepl ikigirvmks lsinekdfvt 481 maieiindir dddiekqeqe ekikskkinr rnetsvdeed engthndevn edeeddniss 541 fhsavenlvq gngnvsesdi innlppekea ssativlclt rssymlelvn tpltenilia 601 slmdtlitpa vrntapnire lgvknlglcc lldvklaidn myilgmcvsk gnaslkyial 661 qvivdifsvh gntvvdgegk vdsislhkif ykvlknnglp ecqviaaegl cklfladvft 721 dddlfetlvl syfspinssn ealvqafafc ipvycfshpa hqqrmsrtaa dillrlcvlw 781 ddlqssvipe vdreamlkpn iifqqllfwt dprnlvnqtg stkkdtvqlt flidvlkiya 841 qiekkeikkm iitninaifl sseqdystlk elleysddia endnldnvsk naldklrnnl 901 nslieeiner setqtkdenn tandqyssil gnsfnkssnd tiehaaditd gnnteltktt 961 vnisavdntt eqsnsrkrtr seaeqidtsk nlenmsiqdt stvaknvsfv lpdeksdams 1021 ideedkdses fsevc // LOCUS NP_010613 1438 aa linear PLN 30-JUN-2025 DEFINITION Ysp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010613 VERSION NP_010613.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180634.1 REFERENCE 1 (residues 1 to 1438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1438) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12169. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1438 /product="Ysp2p" /calculated_mol_wt="160448" Region 660..753 /region_name="PH-GRAM_GRAMDC" /note="GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; cd13220" /db_xref="CDD:275406" Region 854..998 /region_name="VASt" /note="VAD1 Analog of StAR-related lipid transfer domain; pfam16016" /db_xref="CDD:464975" Region 1062..1205 /region_name="VASt" /note="VAD1 Analog of StAR-related lipid transfer domain; pfam16016" /db_xref="CDD:464975" CDS 1..1438 /gene="YSP2" /locus_tag="YDR326C" /gene_synonym="LAM2; LTC4" /coded_by="NM_001180634.1:1..4317" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962064]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:26001273]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:26001273]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:29339490]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:33255682]" /experiment="EXISTENCE:mutant phenotype:GO:0032366 intracellular sterol transport [PMID:26001273]" /note="Sterol-binding protein located at plasma membrane-ER contact sites; role in retrograde transport of sterols from plasma membrane to ER, which is inhibited via phosphorylation by TORC2-dependent protein kinase Ypk1p; contains two StART-like domains that bind sterols and a GRAM domain; co-localizes to puncta in the cortical ER with Sip3p; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes" /db_xref="GeneID:851926" /db_xref="SGD:S000002734" ORIGIN 1 mrdeatrkkr sfsdghffkk lklmsrkkqp vmerskttrt rkestnsaak sslslrrann 61 grktiakrrv ltdigstneg vagnsgsnsp aqyshtphfs dsipplplel pdivsirssr 121 shisnksnkn khgidltfip rrslqnskag lkkpntspqg yfnipvtidr asekvkhtdt 181 kntfnsssse nerpvlsilq kddsqssshp aidsmsapnn innnndiens snslfdtils 241 iahsaishvp kisalnteiq refshsgesh tgstrhpyfh ihhaqqqhpl sqqqgplpvs 301 enanqnpndt vlihspsant ahrsssflrh ldyllsptsg pasdkhtqve egddeeelsp 361 lskaflspst qlvptntstt plsgsltpnn rnvnansnse tendndrddr snvgkvkfqp 421 lkvhepaist fgkgnltlea vagssdidnt tidldenntn nnpnasstnl shisksnvnn 481 nlgpkelnts yrnstyidma rfensqsnls shrarsktlp ankalenavg degnskrnsr 541 yssysndmaf ddaderkfrs mskkflnrrs fspsnlgnkv ipginlrnsf nknrnsssdf 601 fstnqgqqmp rtstagsgni haimgldsgn ddfklegiey asekknsefh tlfkdcdinp 661 neklivdhsc alsrdillqg rmyisdahig ffsnilgwvs tvfipfkeiv qiekkttagi 721 fpngividtl htkyifasfm srdatfdlit dvwnqiilgk kyrngfgnnd dgtisdsssa 781 ffddsddndd dgdlddddpd instdmtssd didadvfnes ndlgknqkst nyllgpnkhs 841 pttadfkpsn ndhlvieani naplgkvvnl lygedvsyye rilkaqknfe ispipnnflt 901 kkirdyaytk plsgsigpsk tkclitdtle hydledyvkv lsitknpdvp sgnifsvktv 961 flfswdknns tkltvynsvd wtgkswiksm iekgtfdgva dttkimisei kkilsdedsn 1021 inskhqasnn eseeeiinlp tigppvhdpt epdfqkgkdd tvidekinip vplgtvfsll 1081 ygddtsyikk iienqnnfnv cdipkfvnna reitytkkln nsfgpkqtkc ivtetiehmd 1141 lnsffmvkqi vrspdvpygs sfsvhtrffy swgdhnttnm kvvtnvvwtg ksmlkgtiek 1201 gsidgqrsst kqlvddlkki isnasstkkk srrrgktvnk rksspstikn ekneenfedt 1261 stknsffsaf smlqqvnits vqgimtiisf ficlifffrl lfhskntsni qiitpgtili 1321 ngneynyvpn fktlyhvyed niikdarrkd snknnivtdt egliwdwlid rgngtvqnsv 1381 lsnhikesnn kkvklvngvs dhkiqqlves ikitelqlqe mkellaqtdn tsatnqll // LOCUS NP_010615 194 aa linear PLN 30-JUN-2025 DEFINITION SCF ubiquitin ligase subunit SKP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010615 VERSION NP_010615.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180636.3 REFERENCE 1 (residues 1 to 194) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 194) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 194) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 194) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12170. On Jul 30, 2012 this sequence version replaced NP_010615.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..194 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..194 /product="SCF ubiquitin ligase subunit SKP1" /calculated_mol_wt="22199" Region 3..194 /region_name="SKP1" /note="SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]; COG5201" /db_xref="CDD:227528" CDS 1..194 /gene="SKP1" /locus_tag="YDR328C" /gene_synonym="MGO1" /coded_by="NM_001180636.3:1..585" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16421250]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:9346239]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9346239|PMID:9346238]" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:9346238|PMID:9346239]" /experiment="EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:9346238|PMID:9346239]" /experiment="EXISTENCE:direct assay:GO:0031518 CBF3 complex [PMID:8706132|PMID:8670864]" /experiment="EXISTENCE:direct assay:GO:0051382 kinetochore assembly [PMID:12084919]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:9346238]" /experiment="EXISTENCE:direct assay:GO:0065003 protein-containing complex assembly [PMID:15090617]" /experiment="EXISTENCE:genetic interaction:GO:0007035 vacuolar acidification [PMID:11283612]" /experiment="EXISTENCE:genetic interaction:GO:0031518 CBF3 complex [PMID:8706132]" /experiment="EXISTENCE:genetic interaction:GO:0045116 protein neddylation [PMID:9531531]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8706132|PMID:8706131]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:8706131|PMID:8706132]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:16330709]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:11283612]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:17205042]" /experiment="EXISTENCE:mutant phenotype:GO:0010458 exit from mitosis [PMID:17205042]" /experiment="EXISTENCE:mutant phenotype:GO:0045116 protein neddylation [PMID:9531531]" /experiment="EXISTENCE:mutant phenotype:GO:0051382 kinetochore assembly [PMID:12084919]" /experiment="EXISTENCE:mutant phenotype:GO:2000766 negative regulation of cytoplasmic translation [PMID:26310304]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12769845]" /experiment="EXISTENCE:physical interaction:GO:0007096 regulation of exit from mitosis [PMID:17205042]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:9346238|PMID:9346239]" /experiment="EXISTENCE:physical interaction:GO:0031518 CBF3 complex [PMID:8670864]" /experiment="EXISTENCE:physical interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:11283612]" /experiment="EXISTENCE:physical interaction:GO:0043291 RAVE complex [PMID:11844802|PMID:11283612]" /note="Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851928" /db_xref="SGD:S000002736" ORIGIN 1 mvtsnvvlvs gegerftvdk kiaerslllk nylndmhdsn lqnnsdsesd sdsetnhksk 61 dnnngdddde dddeivmpvp nvrssvlqkv iewaehhrds nfpdedddds rksapvdswd 121 reflkvdqem lyeiilaany lnikplldag ckvvaemirg rspeeirrtf nivndftpee 181 eaairrenew aedr // LOCUS NP_010616 441 aa linear PLN 30-JUN-2025 DEFINITION Pex3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010616 VERSION NP_010616.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180637.3 REFERENCE 1 (residues 1 to 441) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 441) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 441) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 441) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12171. On Jul 30, 2012 this sequence version replaced NP_010616.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..441 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..441 /product="Pex3p" /calculated_mol_wt="50545" Region 13..430 /region_name="Peroxin-3" /note="pfam04882" /db_xref="CDD:428171" CDS 1..441 /gene="PEX3" /locus_tag="YDR329C" /gene_synonym="PAS3" /coded_by="NM_001180637.3:1..1326" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:23900285]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:1894692]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16009135]" /experiment="EXISTENCE:direct assay:GO:0032581 ER-dependent peroxisome organization [PMID:17646399]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:23900285]" /experiment="EXISTENCE:mutant phenotype:GO:0032581 ER-dependent peroxisome organization [PMID:20427571]" /experiment="EXISTENCE:mutant phenotype:GO:0045033 peroxisome inheritance [PMID:19948495]" /experiment="EXISTENCE:mutant phenotype:GO:0045046 protein import into peroxisome membrane [PMID:10637226]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9418908]" /note="Peroxisomal membrane protein (PMP); required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p" /db_xref="GeneID:851929" /db_xref="SGD:S000002737" ORIGIN 1 mapnqrsrsl lqrhrgkvli sltgiaalft tgsvvvffvk rwlykqqlri teqhfikeqi 61 krrfeqtqed slytiyellp vwrmvlnend lnldsivtql kdqknqltra kssesressp 121 lkskaelwne lelksliklv tvtytvssli lltrlqlnil trneyldsai kltmqqencn 181 klqnrfynwv tswwsdpedk addamvmaak kskkegqevy ineqaflsls wwilnkgwls 241 yneiitnqie iefdgihprd tltleefssr ltnifrntns qifqqnnnnl tsillpkdss 301 gqefllsqtl dadaltsfhs ntlvfnqlvn eltqciesta tsivleslin esfhfimnkv 361 giktiakkkp gqedqqqyqm avfamsmkdc cqemlqttag sshsgsvney latldsvqpl 421 ddlsasvysn fgvsssfsfk p // LOCUS NP_010617 500 aa linear PLN 30-JUN-2025 DEFINITION DNA protein crosslink repair co-factor UBX5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010617 VERSION NP_010617.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180638.1 REFERENCE 1 (residues 1 to 500) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 500) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 500) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 500) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12172. Method: conceptual translation. FEATURES Location/Qualifiers source 1..500 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..500 /product="DNA protein crosslink repair co-factor UBX5" /calculated_mol_wt="56606" Region 3..41 /region_name="UBA_Ubx5_like" /note="UBA-like domain found in Saccharomyces cerevisiae UBX domain-containing protein 5 (Ubx5) and similar proteins; cd14346" /db_xref="CDD:270531" Region 219..336 /region_name="UAS" /note="UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain; cd02958" /db_xref="CDD:239256" Region 419..494 /region_name="UBX" /note="Domain present in ubiquitin-regulatory proteins; smart00166" /db_xref="CDD:197552" CDS 1..500 /gene="UBX5" /locus_tag="YDR330W" /coded_by="NM_001180638.1:1..1503" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:21211725]" /note="UBX domain-containing protein that interacts with Cdc48p; ubiquitin regulatory X is also known as UBX" /db_xref="GeneID:851930" /db_xref="SGD:S000002738" ORIGIN 1 msegkvdefm aitgaddaai atqfiemadg nlntaislff enggaallss nntptpsnst 61 pmaptsvdsd adaqlaerlq reayqqqqpd qdyvrppdea rhevltetsg fpisyggigg 121 rfeplhrvnd mfdegrpesi fnqrlddtnt ntyindnssd sldseeendd deyeyveepv 181 ieldedgnik eytklvrkpk tiskeqklal lfrppfsims kldldaakqk arakqkwimi 241 niqdsgifqc qalnrdlwss rpvktiiken fvflqyqyes rnaqpylqfy hlnnkddlph 301 iaildpitge rvkqwnrvvp ipeqfisein eflasfsldp kvpnptvnep lpkvdpttlt 361 eeqqmelaik eslnnnssks nqeevpstge eqkrvqepdp fstiearvhp eppnkpgitt 421 riqirtgdgs rlvrrfnale dtvrtiyevi ktemdgfads rftlndhqre dlidklnmti 481 adaglknssl llekldpeie // LOCUS NP_010618 411 aa linear PLN 30-JUN-2025 DEFINITION GPI-anchor transamidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010618 VERSION NP_010618.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180639.1 REFERENCE 1 (residues 1 to 411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 411) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12173. Method: conceptual translation. FEATURES Location/Qualifiers source 1..411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..411 /product="GPI-anchor transamidase" /calculated_mol_wt="47271" Region 38..277 /region_name="CASc" /note="Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; cl00042" /db_xref="CDD:444667" CDS 1..411 /gene="GPI8" /locus_tag="YDR331W" /coded_by="NM_001180639.1:1..1236" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8978684]" /experiment="EXISTENCE:direct assay:GO:0042765 GPI-anchor transamidase complex [PMID:11598210]" /experiment="EXISTENCE:genetic interaction:GO:0003923 GPI-anchor transamidase activity [PMID:10793132]" /experiment="EXISTENCE:mutant phenotype:GO:0016255 attachment of GPI anchor to protein [PMID:11598210|PMID:10727241]" /note="Catalytic subunit of the ER membrane GPI transamidase complex; involved in adding glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; luminally-oriented type I integral membrane glycoprotein of the ER; human PIGK protein is a functional homolog" /db_xref="GeneID:851931" /db_xref="SGD:S000002739" ORIGIN 1 mriamhlpll llyifllpls ganntdaahe viatntnnwa vlvstsrfwf nyrhmanvls 61 myrtvkrlgi pdsqiilmls ddvacnsrnl fpgsvfnnkd haidlygdsv evdyrgyevt 121 venfirlltd rwtedhpksk rlltdensni fiymtghggd dflkfqdaee iasediadaf 181 qqmyekkryn eiffmidtcq antmyskfys pnilavgsse mdessyshhs dveigvavid 241 rftyycldfl eqidknstlt lqdlfdsftf ekihshvgvr tdlfdrnpse vlitdffanv 301 qnvipddskp lsvshyhhyk dhidtaqyel nnnvldlale tyrknnqssk iekkikdiks 361 tsvldvdids necfftsfkq satiilaliv tilwfmlrgn takatydlyt n // LOCUS NP_010619 689 aa linear PLN 30-JUN-2025 DEFINITION double-stranded DNA-dependent ATPase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010619 VERSION NP_010619.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180640.3 REFERENCE 1 (residues 1 to 689) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 689) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 689) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 689) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12174. On Jul 30, 2012 this sequence version replaced NP_010619.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..689 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..689 /product="double-stranded DNA-dependent ATPase" /calculated_mol_wt="78416" Region 25..545 /region_name="SSL2" /note="Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; COG1061" /db_xref="CDD:440681" CDS 1..689 /gene="IRC3" /locus_tag="YDR332W" /coded_by="NM_001180640.3:1..2070" /experiment="EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:32735705]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:25389272]" /experiment="EXISTENCE:direct assay:GO:0036121 double-stranded DNA helicase activity [PMID:25389272]" /experiment="EXISTENCE:direct assay:GO:0061749 forked DNA-dependent helicase activity [PMID:32735705]" /experiment="EXISTENCE:mutant phenotype:GO:0032042 mitochondrial DNA metabolic process [PMID:25389272]" /experiment="EXISTENCE:mutant phenotype:GO:1905082 regulation of mitochondrial translational elongation [PMID:34398681]" /note="Double-stranded DNA-dependent helicase of the DExH/D-box family; branch point-binding helicase that preferentially unwinds the nascent lagging strand with a 3' to 5' polarity at a replication fork; contains double-stranded DNA translocase activity; responsible for DNA branch migration; required for maintenance of the mitochondrial (mt) genome; localizes to the mitochondrial matrix; monomeric" /db_xref="GeneID:851932" /db_xref="SGD:S000002740" ORIGIN 1 mtstlatrls tysislilqr ikiikrcysa pvlrdyqqda idacvnsirq gtkrigvsla 61 tgggktvifs nlinqlrqny fkerqgnfks lilvhrrela lqatatlkki fpdlkvhiem 121 gkydcdieds dvivasvqtl irrlhkydtn svnliiidea hhsvansyrs ildhfkasta 181 etkipvigfs atferadkra lsmvmdkivy hrgilemidd kwlceakfts vkieadlsdv 241 kstaddfqla plsslmntke inevilktyl hkkqekslks tllfgvdkah vqslhklfkd 301 ngintdyvts dtkqierdni iqkfkngete vlmncgifte gtdmpnidci llcrptksrs 361 lliqmigrgl rlhhskdhch iidfigassv gvvsaptllg irsddiefdd atvedlkaiq 421 geiiakqqki derlralfqt deaamenvte rnsvadwihs ansvdltlcs fdsfrnftqs 481 nnsypsgkef deaseavkem ellmnsqypw vkfasnawgl plkgknhlri ykeksedkls 541 mvyhlkmyrq lpcfitnkya dyvpksiikd anlwnvmskv ekiintlnsd legqtmqyqa 601 isskyskwrq tvptskqrdf vfrklkkvyg esskdfirls lddvttyvnt kmtkgdasnl 661 ifasslapvy plksllrile yqkrrsfik // LOCUS NP_010620 723 aa linear PLN 30-JUN-2025 DEFINITION Rqc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010620 VERSION NP_010620.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180641.3 REFERENCE 1 (residues 1 to 723) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 723) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 723) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 723) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 723) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 723) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 723) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 723) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 723) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12175. On Jul 30, 2012 this sequence version replaced NP_010620.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..723 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..723 /product="Rqc1p" /calculated_mol_wt="83295" Region 327..663 /region_name="Tcf25" /note="Transcriptional repressor TCF25; pfam04910" /db_xref="CDD:461476" CDS 1..723 /gene="RQC1" /locus_tag="YDR333C" /coded_by="NM_001180641.3:1..2172" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:27129255]" /experiment="EXISTENCE:direct assay:GO:0072344 rescue of stalled ribosome [PMID:27129255]" /experiment="EXISTENCE:direct assay:GO:1990112 RQC complex [PMID:23178123]" /experiment="EXISTENCE:direct assay:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:27129255]" /experiment="EXISTENCE:genetic interaction:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23479637]" /experiment="EXISTENCE:mutant phenotype:GO:0072344 rescue of stalled ribosome [PMID:26943317]" /experiment="EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23479637]" /experiment="EXISTENCE:physical interaction:GO:1990112 RQC complex [PMID:23479637]" /note="Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Rqc2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Rkr1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC" /db_xref="GeneID:851933" /db_xref="SGD:S000002741" ORIGIN 1 mssralrrlq ddnallesll snsnankmts gkstagniqk renifsmmnn vrdsdnstde 61 gqmseqdeea aaagerdtqs ngqpkritla skssrrkknk kakrkqknht aeaakdkgsd 121 dddddeefdk iiqqfkktdi lkygktkndd tneegfftas epeeassqpw ksflslesdp 181 gftkfpiscl rhsckffqnd fkkldphtef kllfddispe sledidsmts tpvspqqlkq 241 iqrlkrlirn wggkdhrlap ngpgmhpqhl kftkirddwi ptqrgelsmk llssddlldw 301 qlwerpldwk dviqndvsqw qkfisfykfe plnsdlskks mmdfylsviv hpdhealinl 361 isskfpyhvp gllqvalifi rqgdrsntng llqralfvfd ralkaniifd slncqlpyiy 421 ffnrqfylai fryiqslaqr gvigtasewt kvlwslsple dplgcryfld hyfllnndyq 481 yiielsnspl mncykqwntl gfslavvlsf lrinemssar nallkafkhh plqlselfke 541 kllgdhaltk dlsidghsae nlelkaymar fpllwnrnee vtflhdemss ilqdyhrgnv 601 tidsndgqdh nninnlqspf fiagipinll rfailseess vmaaipsfiw sdnevyefdv 661 lppmptskes ievveniktf inekdlavlq aermqdedll nqirqislqq yiheneesne 721 neg // LOCUS NP_010621 1514 aa linear PLN 30-JUN-2025 DEFINITION chromatin-remodeling protein SWR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010621 VERSION NP_010621.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180642.1 REFERENCE 1 (residues 1 to 1514) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1514) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1514) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1514) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12176. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1514 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1514 /product="chromatin-remodeling protein SWR1" /EC_number="3.6.4.12" /calculated_mol_wt="174400" Region 340..>393 /region_name="HSA" /note="domain in helicases and associated with SANT domains; smart00573" /db_xref="CDD:214727" Region <649..1393 /region_name="HepA" /note="Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair]; COG0553" /db_xref="CDD:440319" Region 696..932 /region_name="DEXQc_SRCAP" /note="DEXH/Q-box helicase domain of SRCAP; cd18003" /db_xref="CDD:350761" Site order(723..729,763,824..825) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350761" CDS 1..1514 /gene="SWR1" /locus_tag="YDR334W" /coded_by="NM_001180642.1:1..4545" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14690608|PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0031492 nucleosomal DNA binding [PMID:35263135]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:31533921]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:16299513]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:14690608]" /note="Swi2/Snf2-related ATPase; catalytic subunit of SWR1 complex, which exchanges histone variant H2A.Z (Htz1p) for chromatin-bound histone H2A; N-terminus can deliver H2A.Z-H2B dimer to DNA-(H3-H4)2 tetrasome; relocalizes to cytosol in response to hypoxia; chronological aging factor, mediates lifespan extension by dietary restriction" /db_xref="GeneID:851934" /db_xref="SGD:S000002742" ORIGIN 1 mttsrkshak dkkaggeqdl adlkfrydll tnelfhlref vslvdydpth fndsesfqkf 61 lrethlslee rgekftddva kkgtngdltr rrrnlrtstv vssettnekk gdielklesi 121 aplvrnkcee lkyklsdhsn rksivpqkrp iqhlkkreaa kslkfkserk enplplhehi 181 aeerydhiak veepseafti kcpsddssfe ntsehysdnf yfttsseeed ikkkrgrkkk 241 kpriklvvhp pkqtitnplh vvkpgyeslh eyiasfksle ddltleeynk yideqrrlls 301 rlkkgienga lkydketdsl qpitskeikt iitykpdpis yfykqqdlqi htdhlinqgi 361 hmsklfrsst kariarakkv sqmieqhfkh vagaeerkak eeerhkksla rfavqavkkr 421 wnmaekayri lrkdeeeqlk riegkqhlsk mlekstqlle aqlnqvnddg rsstpssdsn 481 dvlsesdddm ddelstssde deevdadvgl enspasteat ptdeslnliq lkekyghfng 541 sstvydsrnk dekfptldkh essssessvm tgeessiyss senesqnend resddktpsv 601 glsalfgkge esdgdldldd sedftvnsss vegeelekdq vdnsaatfer agdfvhtqne 661 nrddikdvee daetkvqeeq lsvvdvpvps llrgnlrtyq kqglnwlasl ynnhtngila 721 demglgktiq tisllaylac ekenwgphli vvptsvllnw emefkrfapg fkvltyygsp 781 qqrkekrkgw nkpdafhvci vsyqlvvqdq hsfkrkrwqy mvldeahnik nfrstrwqal 841 lnfntqrrll ltgtplqnnl aelwsllyfl mpqtvidgkk vsgfadldaf qqwfgrpvdk 901 iietgqnfgq dketkktvak lhqvlrpyll rrlkadvekq mpakyehivy cklskrqrfl 961 yddfmsraqt katlasgnfm sivnclmqlr kvcnhpnlfe vrpiltsfvl ehcvasdykd 1021 vertllklfk knnqvnrvdl dflnlvftln dkdltsyhae eiskltcvkn fveevnklre 1081 tnkqlqeefg easflnfqda nqyfkysnkq klegtvdmln flkmvnklrc drrpifgknl 1141 idlltkdrrv kydkssiidn elikplqtrv ldnrkiidtf avltpsavsl dmrklalgln 1201 ddssvgentr lkvmqncfev snplhqlqtk ltiafpdksl lqydcgklqk laillqqlkd 1261 nghraliftq mtkvldvleq flnyhgylym rldgatkied rqilterfnt dsritvfils 1321 srsgglginl tgadtvifyd sdwnpamdkq cqdrchrigq trdvhiyrfv sehtiesnil 1381 kkanqkrqld nvviqegdft tdyfsklsvr dllgselpen asggdkplia dadvaakdpr 1441 qlerllaqae deddvkaanl amreveidnd dfdestekka aneeeenhae ldeyegtahv 1501 deymirfian gyyy // LOCUS NP_010622 1224 aa linear PLN 30-JUN-2025 DEFINITION karyopherin MSN5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010622 VERSION NP_010622.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180643.1 REFERENCE 1 (residues 1 to 1224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1224) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12177. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1224 /product="karyopherin MSN5" /calculated_mol_wt="141987" Region 23..>172 /region_name="CRM1" /note="Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]; COG5101" /db_xref="CDD:227432" Region 332..1186 /region_name="Exportin-5" /note="Exportin-5 family; pfam19273" /db_xref="CDD:437105" CDS 1..1224 /gene="MSN5" /locus_tag="YDR335W" /gene_synonym="KAP142; STE21" /coded_by="NM_001180643.1:1..3675" /experiment="EXISTENCE:direct assay:GO:0005049 nuclear export signal receptor activity [PMID:9214382]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10485850|PMID:10545454|PMID:17020589]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17020589]" /experiment="EXISTENCE:direct assay:GO:0006611 protein export from nucleus [PMID:9853758|PMID:12697814]" /experiment="EXISTENCE:genetic interaction:GO:0071528 tRNA re-export from nucleus [PMID:20032305]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:23716718]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12697814]" /note="Karyopherin; involved in nuclear import and export of proteins, including import of replication protein A and export of Far1p and transcription factors Swi5p, Swi6p, Msn2p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm; exportin-5 homolog" /db_xref="GeneID:851935" /db_xref="SGD:S000002743" ORIGIN 1 mdstgasqiv saldviyspk snnsqrqeaq kfldevklcs espfwgyeia lqnptnsilk 61 yfglglldha vkknwndyde gkrvalrkwv melnfgvqdy dtryikekla tlwvevakrt 121 wgealkqtnp teeqlltswv dmdnnlfelw ninqssrela liifrilfed vfllddlivl 181 krmtviqplc vmivcpievf aikykfsdkw tkfkaneegw fsvwipelnn alqqnnseyi 241 irlletlktc lnwplteviv rndvlssllt clssnipraq smaldsihil ltrpysnesh 301 yqmtidrvfd nmdlldsvye sllfdptddi detkypiikk fvdmisclyv cvpkiketng 361 qiqkyfklvl kttynpsliv sgltldlwct clrndeylpk lekyvipdll qfaadalvyy 421 eqidghiskk faeidfqsks efqtfcstyr krirdiirli scveldltyd wlnnrlnnyf 481 sspfgqqvls stfldhklep ylgalsqymi vecfingcir wkiwyptgdd ydekldsilq 541 kleilsnqli alnlreplll kkqiqnfalf ltmlkdnvlf tllekiitsa tmdypeinle 601 ergaesdavr dlryacgiel nrmallmpes lkkiypdles viarimpnls yhekisfksf 661 lliivlkssl dmkeerfaai vdpellawsd kttvvglsdl hwfmerlgiv qiaeyfqrrd 721 idensdllsi piddegkelk seltkrwqsl fpvratrmfi hysmqsiktd eefkmlqdlw 781 rprivpilpy itrllyqlqs yhdpdnwkgl ptvvqsfvky stierfweag asnkskdefi 841 dehmkamqtl rdfadsvghi irytreytll vlsaisslgs vfylldespd lllnsiaifk 901 pgsneispgv sthgwkhimn iairpilkgc pkdclgkfmp aflpklfeil dlllcqkwss 961 hmndmdmnpv ptdddqmtee ileenllrql ttvvvrivid cvgqgnanpn saksrlnnhq 1021 memrkiifnd lntlapflkl lnhlisfkdt kcsfnsilvm kccltsvlnq nntvdeyftf 1081 evmknlllnv lcnsafkdsf healyaftvi fltlckeyps araflfeisn gynidelyrn 1141 lrsvdeyktq ralmidfidw vkstsgkedg nvdhagderk rqekreailk kanerlikkn 1201 kengdmlddp niedgavgnl fddn // LOCUS NP_010623 314 aa linear PLN 30-JUN-2025 DEFINITION translation initiation/elongation factor MRX8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010623 VERSION NP_010623.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180644.3 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12178. On Jul 30, 2012 this sequence version replaced NP_010623.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..314 /product="translation initiation/elongation factor MRX8" /calculated_mol_wt="35483" Region 135..310 /region_name="YihA_EngB" /note="YihA (EngB) GTPase family; cd01876" /db_xref="CDD:206665" Site 140..147 /site_type="other" /note="G1 box" /db_xref="CDD:206665" Site order(142..148,168..170,173..175,191,254,256,286..287) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206665" Site 172..178 /site_type="other" /note="Switch I region" /db_xref="CDD:206665" Site 175 /site_type="other" /note="G2 box" /db_xref="CDD:206665" Site 191..194 /site_type="other" /note="G3 box" /db_xref="CDD:206665" Site order(194..197,199..213,216..217) /site_type="other" /note="Switch II region" /db_xref="CDD:206665" Site 253..256 /site_type="other" /note="G4 box" /db_xref="CDD:206665" Site 286..288 /site_type="other" /note="G5 box" /db_xref="CDD:206665" CDS 1..314 /gene="MRX8" /locus_tag="YDR336W" /coded_by="NM_001180644.3:1..945" /experiment="EXISTENCE:direct assay:GO:0099617 matrix side of mitochondrial inner membrane [PMID:34432493]" /experiment="EXISTENCE:mutant phenotype:GO:0019001 guanyl nucleotide binding [PMID:34432493]" /experiment="EXISTENCE:mutant phenotype:GO:0070124 mitochondrial translational initiation [PMID:34432493]" /experiment="EXISTENCE:mutant phenotype:GO:0070125 mitochondrial translational elongation [PMID:34432493]" /note="Conserved mitochondrial YihA GTPase family member; required for efficient cellular respiration; localizes to mitochondrial inner membrane facing matrix side; associates with mitochondrial ribosome; required for de novo Cox1p synthesis at suboptimal temperatures; sumoylated under stress conditions" /db_xref="GeneID:851936" /db_xref="SGD:S000002744" ORIGIN 1 meqlckryvh tpaafiqniv antkrttlat qlsvekakkk vpktalkkkl nsrpkerlpn 61 wlklndvfni hyekpsnsdi nkvnrffnka kvefewcaas fddipenpfl nkkshkdilk 121 dhgecgttli dtlpeviflg gtnvgkssil nnittshvsr dlgslarvsk ttgftktlnc 181 ynvgnrlrmi dspgygfnss keqgkvtlqy llerkqlvrc flllagdkei nntdnmiiqy 241 ihehgvpfev vftkmdkvkd lnkfkkkvms sglmdlptlp rlvltnslts stspkrfgid 301 llryvifqsc glil // LOCUS NP_010624 286 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS15m MRPS28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010624 VERSION NP_010624.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180645.3 REFERENCE 1 (residues 1 to 286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 286) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12179. On Jul 30, 2012 this sequence version replaced NP_010624.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..286 /product="mitochondrial 37S ribosomal protein uS15m MRPS28" /calculated_mol_wt="32926" Region 161..236 /region_name="Ribosomal_S15" /note="Ribosomal protein S15; pfam00312" /db_xref="CDD:459756" CDS 1..286 /gene="MRPS28" /locus_tag="YDR337W" /gene_synonym="uS15m" /coded_by="NM_001180645.3:1..861" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:851937" /db_xref="SGD:S000002745" ORIGIN 1 msivgrnail nlrislcplf mgkrsfvssp vsnsakavkf lkaqrrkqkn eakqatlkas 61 tdkvdpvlgr adtpfitrim aelkeplvls kgynieevdk flaaiesakr eraelsglnt 121 evvgiediek ledrreailr ilsmrnsenk naikmavela rkeferfpgd tgssevqaac 181 mtvriqnman hikehrkdfa ntrnlrilvq qrqailrylk rdnpekyywt iqklglndaa 241 itdefnmdrr ymqdyeffgd kilirdskkv anqkrkeirk qkratf // LOCUS NP_010625 695 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR338C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010625 VERSION NP_010625.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180646.1 REFERENCE 1 (residues 1 to 695) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 695) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 695) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 695) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12180. Method: conceptual translation. FEATURES Location/Qualifiers source 1..695 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..695 /product="uncharacterized protein" /calculated_mol_wt="77715" Region 228..658 /region_name="MATE_eukaryotic" /note="Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; cd13132" /db_xref="CDD:240537" Site order(467,471,497,500,579,583,610,636,640) /site_type="other" /note="putative cation binding site [ion binding]" /db_xref="CDD:240537" CDS 1..695 /locus_tag="YDR338C" /coded_by="NM_001180646.1:1..2088" /experiment="EXISTENCE:curator inference:GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane [PMID:30520011]" /note="hypothetical protein; member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily" /db_xref="GeneID:851938" /db_xref="SGD:S000002746" ORIGIN 1 magilsktls evhpslrtng mgignthrri slgflppnkk nplvrkfrar trnidqrsfr 61 sltddfgsnv hepnpylgni deepdlyyhd eedgelsrti slpsrvsetp elspqdvdwi 121 lheherryss vcnsdneeas qsntpdriqe ysgreleyde fmnrlqaqkq kltrsavtda 181 kgtshhrrps fvsvtsrgsv ptiyqeiden dsealaelah shvtfksear vlasysfpli 241 ftflleqifp mvcsltvghl gknelaavsl asmtsnitla ifegiatsld tlcpqaygsg 301 rfysvgvhlq rciafslviy ipfavmwwys epllsyiipe kelinltsrf lrvlilgapa 361 yiffenlkrf lqaqgifdag iyvlticapl nvlvsytlvw nkyigvgfig aaiavvlnfw 421 lmfflllfya lyidgrkcwg gfsrkafthw ndlghlafsg iimleaeels yelltlfsay 481 ygvsylaaqs avstmaally mipfaigist strianfiga krtdfahiss qvglsfsfia 541 gfinccilvf grnlianiys kdpeviklia qvlplvgivq nfdslnavag sclrgqgmqs 601 lgsivnlmay ylfgiplali lswffdmkly glwigigsam lliglveayy vlfpdwdkim 661 tyaeilkete ddevdsdeyl tdsddpdent allga // LOCUS NP_010626 189 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein FCF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010626 VERSION NP_010626.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180647.1 REFERENCE 1 (residues 1 to 189) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 189) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 189) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 189) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12181. Method: conceptual translation. FEATURES Location/Qualifiers source 1..189 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..189 /product="rRNA-processing protein FCF1" /calculated_mol_wt="21480" Region 53..183 /region_name="PIN_Fcf1-like" /note="VapC-like PIN domain of rRNA-processing protein, Fcf1 (Utp24, YDR339C), and other eukaryotic homologs; cd09864" /db_xref="CDD:350212" Site order(53,60..61,79,114..121) /site_type="other" /note="UTP 24 binding site [polypeptide binding]" /db_xref="CDD:350212" CDS 1..189 /gene="FCF1" /locus_tag="YDR339C" /gene_synonym="UTP24" /coded_by="NM_001180647.1:1..570" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:27034467]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16762320|PMID:16769905]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:16769905]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16762320|PMID:16769905]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16769905|PMID:16762320]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16769905|PMID:16762320]" /experiment="EXISTENCE:mutant phenotype:GO:0004521 RNA endonuclease activity [PMID:27034467]" /experiment="EXISTENCE:physical interaction:GO:0032040 small-subunit processome [PMID:16769905]" /note="PINc domain endonuclease; required for early cleavage of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p" /db_xref="GeneID:851939" /db_xref="SGD:S000002747" ORIGIN 1 mgkakktrkf glvkrtlntk kdqrlkknqe niktkedpel trnipqvssa lffqynqaik 61 ppyqvlidtn finfsiqkkv divrgmmdcl lakcnplitd cvmaeleklg pkyrialkla 121 rdprikrlsc shkgtyaddc lvhrvlqhkc yivatndagl kqrirkipgi plmsvgghay 181 vieklpdvf // LOCUS NP_010628 607 aa linear PLN 30-JUN-2025 DEFINITION arginine--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010628 VERSION NP_010628.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180649.3 REFERENCE 1 (residues 1 to 607) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 607) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 607) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 607) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12182. On Jul 30, 2012 this sequence version replaced NP_010628.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..607 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..607 /product="arginine--tRNA ligase" /EC_number="6.1.1.19" /calculated_mol_wt="69394" Region 31..607 /region_name="argS" /note="arginyl-tRNA synthetase; TIGR00456" /db_xref="CDD:273085" CDS 1..607 /locus_tag="YDR341C" /gene_synonym="RRS1" /coded_by="NM_001180649.3:1..1824" /experiment="EXISTENCE:direct assay:GO:0004814 arginine-tRNA ligase activity [PMID:9622124]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006420 arginyl-tRNA aminoacylation [PMID:9622124]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Arginyl-tRNA synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDR341C has a paralog, MSR1, that arose from the whole genome duplication" /db_xref="GeneID:851942" /db_xref="SGD:S000002749" ORIGIN 1 mastanmisq lkklsiaepa vakdshpdvn ivdlmrnyis qelskisgvd sslifpalew 61 tntmergdll ipiprlrikg anpkdlavqw aekfpcgdfl ekveangpfi qfffnpqfla 121 klvipdiltr kedygscklv enkkviiefs spniakpfha ghlrstiigg flanlyeklg 181 wevirmnylg dwgkqfglla vgferygnee alvkdpihhl fdvyvrinkd ieeegdsipl 241 eqstngkare yfkrmedgde ealkiwkrfr efsiekyidt yarlnikydv ysgesqvske 301 smlkaidlfk ekglthedkg avlidltkfn kklgkaivqk sdgttlyltr dvgaamdrye 361 kyhfdkmiyv iasqqdlhaa qffeilkqmg fewakdlqhv nfgmvqgmst rkgtvvfldn 421 ileetkekmh evmkknenky aqiehpeeva dlvgisavmi qdmqgkrinn yefkwermls 481 fegdtgpylq yahsrlrsve rnasgitqek winadfsllk epaakllirl lgqypdvlrn 541 aikthepttv vtylfklthq vsscydvlwv agqteelata rlalygaarq vlyngmrllg 601 ltpverm // LOCUS NP_010629 570 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010629 VERSION NP_010629.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180650.3 REFERENCE 1 (residues 1 to 570) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 570) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 570) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 570) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12183. On Jul 30, 2012 this sequence version replaced NP_010629.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..570 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..570 /product="hexose transporter HXT7" /calculated_mol_wt="62604" Region 68..528 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(79,83,209,212..213,216,335..336,340..341,344..345, 370,440..441,444..445,449,472..473,476) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..570 /gene="HXT7" /locus_tag="YDR342C" /coded_by="NM_001180650.3:1..1713" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11904149|PMID:12469340|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0055056 D-glucose transmembrane transporter activity [PMID:12702270]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1904659 D-glucose transmembrane transport [PMID:12702270]" /experiment="EXISTENCE:mutant phenotype:GO:0015146 pentose transmembrane transporter activity [PMID:17180689]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:20525688]" /note="High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels; HXT7 has a paralog, HXT4, that arose from the whole genome duplication" /db_xref="GeneID:851943" /db_xref="SGD:S000002750" ORIGIN 1 msqdaaiaeq tpvehlsavd sashsvlstp snkaerdeik aygegeehep vveipkrpas 61 ayvtvsimci miafggfvfg wdtgtisgfi nqtdfirrfg mkhkdgtnyl skvrtglivs 121 ifnigcaigg iilsklgdmy grkvglivvv viyiigiiiq iasinkwyqy figriisglg 181 vggiavlspm lisevspkhl rgtlvscyql mitagiflgy ctnfgtknys nsvqwrvplg 241 lcfawalfmi ggmtfvpesp rylaevgkie eakrsiavsn kvavddpsvl aeveavlagv 301 eaeklagnas wgelfssktk vlqrlimgam iqslqqltgd nyffyygtti fkavglsdsf 361 etsivlgivn fastfvgiyv verygrrtcl lwgaasmtac mvvyasvgvt rlwpngqdqp 421 sskgagncmi vfacfyifcf attwapipyv vvsetfplrv kskamsiata anwlwgflig 481 fftpfitgai nfyygyvfmg clvfmffyvl lvvpetkglt leevntmwee gvlpwksasw 541 vppsrrgany daeemthddk plykrmfstk // LOCUS NP_010630 570 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010630 VERSION NP_010630.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180651.1 REFERENCE 1 (residues 1 to 570) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 570) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 570) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 570) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12184. Method: conceptual translation. FEATURES Location/Qualifiers source 1..570 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..570 /product="hexose transporter HXT6" /calculated_mol_wt="62574" Region 68..528 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(79,83,209,212..213,216,335..336,340..341,344..345, 370,440..441,444..445,449,472..473,476) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..570 /gene="HXT6" /locus_tag="YDR343C" /coded_by="NM_001180651.1:1..1713" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0055056 D-glucose transmembrane transporter activity [PMID:12702270]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0031966 mitochondrial membrane [PMID:31862471]" /note="High-affinity glucose transporter; member of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3; HXT6 has a paralog, HXT1, that arose from the whole genome duplication" /db_xref="GeneID:851944" /db_xref="SGD:S000002751" ORIGIN 1 msqdaaiaeq tpvehlsavd sashsvlstp snkaerdeik aygegeehep vveipkrpas 61 ayvtvsimci miafggfvfg wdtgtisgfi nqtdfirrfg mkhkdgtnyl skvrtglivs 121 ifnigcaigg iilsklgdmy grkvglivvv viyiigiiiq iasinkwyqy figriisglg 181 vggiavlspm lisevspkhl rgtlvscyql mitagiflgy ctnfgtknys nsvqwrvplg 241 lcfawalfmi ggmtfvpesp rylaevgkie eakrsiavsn kvavddpsvl aeveavlagv 301 eaeklagnas wgelfssktk vlqrlimgam iqslqqltgd nyffyygtti fkavglsdsf 361 etsivlgivn fastfvgiyv verygrrtcl lwgaasmtac mvvyasvgvt rlwpngqdqp 421 sskgagncmi vfacfyifcf attwapipyv vvsetfplrv kskamsiata anwlwgflig 481 fftpfitgai nfyygyvfmg clvfmffyvl lvvpetkglt leevntmwee gvlpwksasw 541 vppsrrgany daeemahddk plykrmfstk // LOCUS NP_001335762 147 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR344C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335762 VERSION NP_001335762.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348817.1 REFERENCE 1 (residues 1 to 147) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 147) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 147) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 147) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80282. Method: conceptual translation. FEATURES Location/Qualifiers source 1..147 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..147 /product="uncharacterized protein" /calculated_mol_wt="17369" CDS 1..147 /locus_tag="YDR344C" /coded_by="NM_001348817.1:1..444" /note="hypothetical protein; conserved among S. cerevisiae strains" /db_xref="GeneID:851945" /db_xref="SGD:S000002752" ORIGIN 1 maflswtffp sffhflernr ffltfatqlh ylnpfyilsf rvewhqiwen laysdtntff 61 heycwkifpc lsagirnngc cdaakgqgkn kqhtpkqeee ipntslrrhr sccnmftcss 121 pcyyleinvg vigvrrpvls eeqrknc // LOCUS NP_010632 567 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010632 VERSION NP_010632.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180653.1 REFERENCE 1 (residues 1 to 567) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 567) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 567) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 567) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12185. Method: conceptual translation. FEATURES Location/Qualifiers source 1..567 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..567 /product="hexose transporter HXT3" /calculated_mol_wt="62427" Region 65..525 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(76,80,206,209..210,213,332..333,337..338,341..342, 367,437..438,441..442,446,469..470,473) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..567 /gene="HXT3" /locus_tag="YDR345C" /coded_by="NM_001180653.1:1..1704" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:24124599|PMID:22544065]" /experiment="EXISTENCE:direct assay:GO:0055056 D-glucose transmembrane transporter activity [PMID:12702270]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1904659 D-glucose transmembrane transport [PMID:12702270]" /note="Low affinity glucose transporter of the major facilitator superfamily; expression is induced in low or high glucose conditions; HXT3 has a paralog, HXT5, that arose from the whole genome duplication" /db_xref="GeneID:851946" /db_xref="SGD:S000002753" ORIGIN 1 mnstpdlisp qkssensnad lpsnssqvmn mpeekgvqdd fqaeadqvlt npntgkgayv 61 tvsiccvmva fggfvfgwdt gtisgfvaqt dflrrfgmkh kdgsyylskv rtglivsifn 121 igcaiggiil aklgdmygrk mglivvvviy iigiiiqias inkwyqyfig riisglgvgg 181 iavlspmlis evapkemrgt lvscyqlmit lgiflgyctn fgtknysnsv qwrvplglcf 241 awalfmiggm tfvpespryl veagqidear aslskvnkva pdhpfiqqel evieasveea 301 raagsaswge lftgkpamfk rtmmgimiqs lqqltgdnyf fyygttvfna vgmsdsfets 361 ivfgvvnffs tccslytvdr fgrrncllyg aigmvccyvv yasvgvtrlw pngegngssk 421 gagncmivfa cfyifcfatt wapiayvvis etfplrvksk amsiataanw lwgfligfft 481 pfitgainfy ygyvfmgcmv fayfyvfffv petkgltlee vndmyaegvl pwksaswvpt 541 sqrganydad almhddqpfy kkmfgkk // LOCUS NP_010633 481 aa linear PLN 30-JUN-2025 DEFINITION Svf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010633 VERSION NP_010633.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180654.3 REFERENCE 1 (residues 1 to 481) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 481) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 481) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 481) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12186. On Jul 30, 2012 this sequence version replaced NP_010633.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..481 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..481 /product="Svf1p" /calculated_mol_wt="54237" Region 56..202 /region_name="Svf1" /note="Svf1-like N-terminal lipocalin domain; pfam08622" /db_xref="CDD:430110" Region 270..468 /region_name="Svf1_C" /note="Svf1-like C-terminal lipocalin-like domain; pfam17187" /db_xref="CDD:465375" CDS 1..481 /gene="SVF1" /locus_tag="YDR346C" /gene_synonym="SGI1" /coded_by="NM_001180654.3:1..1446" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:36897280|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:36897280]" /experiment="EXISTENCE:direct assay:GO:0097001 ceramide binding [PMID:36897280]" /experiment="EXISTENCE:genetic interaction:GO:0030148 sphingolipid biosynthetic process [PMID:36897280]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:36897280]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:16034825]" /note="Ceramide binding protein; putative ceramide transfer protein involved in the nonvesicular transport of ceramides between the endoplasmic reticulum and Golgi apparatus; contributes to sphingolipid biosynthesis at the cis-Golgi; localizes to the cis-Golgi and the cytoplasm; required for the diauxic growth shift; promotes survival in mammalian cells under apoptosis-inducing conditions; mutant has increased aneuploidy tolerance" /db_xref="GeneID:851947" /db_xref="SGD:S000002754" ORIGIN 1 mlkwikggis avtgmaepey gkdyihsvad rvknkqpyre tsredffwqa pdhtnvesvi 61 fyfsdlktgi fgfaqvihsn iiglhtasqf tfrifdsknp edlniwtstk lenfyiegpn 121 fyadnlsvel sedgesyhiq ssvcdlsvvd lhirrltpga kigddpatyy gnninepwgs 181 mrhvfwprna chgtikvkke vipesdeees sadeddnede deesgdseee sgseeesdse 241 eveityedrt itfkeedpai stfimafqgm kphhaakawn fmffhsekys avlmefttpk 301 syantkisag iitddkevla mttnnlvehl nseidsvgwk vpkdikitfk gintkvkdeq 361 lesengteqa lqgedekede kedeeeeeyk nvaeenkica vvegplnnlv eridvmgeip 421 sfvknivsgv agtkpfiyqy adpksstlqi nggekihgva wtevtfises dviseesyne 481 a // LOCUS NP_010634 321 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS43 MRP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010634 VERSION NP_010634.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180655.3 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12187. On Jul 30, 2012 this sequence version replaced NP_010634.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..321 /product="mitochondrial 37S ribosomal protein mS43 MRP1" /calculated_mol_wt="36598" Region <56..>207 /region_name="SodA" /note="Superoxide dismutase [Inorganic ion transport and metabolism]; COG0605" /db_xref="CDD:440370" Region 137..308 /region_name="Sod_Fe_C" /note="Iron/manganese superoxide dismutases, C-terminal domain; pfam02777" /db_xref="CDD:460691" CDS 1..321 /gene="MRP1" /locus_tag="YDR347W" /gene_synonym="mS43" /coded_by="NM_001180655.3:1..966" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein" /db_xref="GeneID:851948" /db_xref="SGD:S000002755" ORIGIN 1 mlrftgarai rkystryale hlkegaplkg lfsieglqka wfdrvkylda klndctneaq 61 qkpletlihe nsksaskkhi vnyasslynl kfsmsslqgc irtppeecpr lgpeallqtp 121 dfnrtisnep lttgnerlqa alissfgslm efrtllinsn laisgdgftw lvarrqldkr 181 amrndmpnrd ieydklfiln tynagtpfnf stsgvmneln nqytnmekqr akeagnleds 241 emtakqaktk fiyetqqkgf sgkevsyipl laidaspktw ltdygvfgkr eylervwdsi 301 ewkivesrlp qrtkiqafnt l // LOCUS NP_010635 499 aa linear PLN 30-JUN-2025 DEFINITION Pal1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010635 VERSION NP_010635.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180656.1 REFERENCE 1 (residues 1 to 499) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 499) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 499) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 499) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12188. Method: conceptual translation. FEATURES Location/Qualifiers source 1..499 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..499 /product="Pal1p" /calculated_mol_wt="54865" Region 236..369 /region_name="Pal1" /note="Pal1 cell morphology protein; pfam08316" /db_xref="CDD:400558" CDS 1..499 /gene="PAL1" /locus_tag="YDR348C" /coded_by="NM_001180656.1:1..1500" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:22190733]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:30679249]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /note="hypothetical protein thought to be involved in endocytosis; physically interacts with Ede1p and is found at endocytic sites at cell periphery during early stages of endocytosis; green fluorescent protein (GFP)-fusion protein localizes to bud neck; potential Cdc28p substrate; similar to S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress; PAL1 has a paralog, YHR097C, that arose from the whole genome duplication" /db_xref="GeneID:851949" /db_xref="SGD:S000002756" ORIGIN 1 menrnsstss rpfsvnnpfr natvdssinq ykndsqfqew aknqsrtnsf dmpqlntrts 61 sqlsfpnipe depqrnadqq gafysglesf ssgslsppsr plssknpfld dvssatdfrr 121 spppvsrnkn hptakeekeq lrqryleesd vstvgntren tdlppsyeei tstngsrray 181 pkekvsrpss hrehsnsgty isrrssshhh reasssstps kkgkrkskvi vpknvdtidk 241 ldvtglfggs fhhdgpfdav tphrnknnka apvlafpvdg pnstiggast kksaldevfg 301 rddtddsdiy qyssqtlrrg gdtqdaikan vgnvqqmdak nktelvhgpv taglgsstfl 361 dgapassaai rndikahsyh nrngglqrnk slsqrlglgg sgdsnapmtg vrrnlslsrd 421 nydvghsneg vrrsktvnsp nrthksnytt dfdgqddhne deedvylgvr ynepnmkkks 481 tgskllsrvk slkvgrksq // LOCUS NP_010636 596 aa linear PLN 30-JUN-2025 DEFINITION putative aspartic endopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010636 VERSION NP_010636.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180657.1 REFERENCE 1 (residues 1 to 596) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 596) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 596) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 596) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12189. Method: conceptual translation. FEATURES Location/Qualifiers source 1..596 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..596 /product="putative aspartic endopeptidase" /calculated_mol_wt="64367" Region 162..442 /region_name="pepsin_retropepsin_like" /note="Cellular and retroviral pepsin-like aspartate proteases; cl11403" /db_xref="CDD:472175" CDS 1..596 /gene="YPS7" /locus_tag="YDR349C" /coded_by="NM_001180657.1:1..1791" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:16087741]" /note="Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum" /db_xref="GeneID:851950" /db_xref="SGD:S000002757" ORIGIN 1 mtclilwylw listfqlefa tastantttt aksgtssste epfpvlavgk dgrgnyyvns 61 tfgtpgqrqr llvdiiqpyi nlvsgtsesh neysgvyhkh psylmndsts svpvspgqiy 121 eisfidgrav nctlvtddmn ftnvssenss talitdlmvt rdnvqfnsgs lsisnvsffd 181 iqssnfktsg llglsgkvtn pgnaidssqy teqsyflsll kdadiiesss yslwlagdts 241 tyktyrdpis ncgklllggv dpslftgtlg kfdlipyvdp vsnavsvgyp ivplgpiyiv 301 snsgqslnmt skdflspall dstssvsylp tstiiqiavq iaatyvesld rwlvqcsiad 361 mgvslgfrlr eltieiplrd llsstydtst nssmffssgq eacfltlyan tntgvnilge 421 afikniymam dledntiaia qakkveddav teetnettas tiikkiksgy ipyakvmnss 481 ntrnltlyps yrsgymftvp gqltaaysng vitgagrsfy dtsrastsar psstqfdsfs 541 vsaseewsns tnrtssasga gvrlsspytf nkdpaghvtr iasllllsif silivl // LOCUS NP_010637 684 aa linear PLN 30-JUN-2025 DEFINITION Atp22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010637 VERSION NP_010637.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180658.4 REFERENCE 1 (residues 1 to 684) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 684) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 684) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 684) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12190. On Jul 30, 2012 this sequence version replaced NP_010637.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..684 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..684 /product="Atp22p" /calculated_mol_wt="79625" CDS 1..684 /gene="ATP22" /locus_tag="YDR350C" /gene_synonym="TCM10" /coded_by="NM_001180658.4:1..2055" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12646576]" /experiment="EXISTENCE:genetic interaction:GO:0045182 translation regulator activity [PMID:17110482]" /experiment="EXISTENCE:genetic interaction:GO:0070131 positive regulation of mitochondrial translation [PMID:17110482]" /experiment="EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:17110482]" /experiment="EXISTENCE:mutant phenotype:GO:0070071 proton-transporting two-sector ATPase complex assembly [PMID:17110482]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:17110482]" /note="Specific translational activator for the mitochondrial ATP6 mRNA; Atp6p encodes a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane" /db_xref="GeneID:851952" /db_xref="SGD:S000002758" ORIGIN 1 mlkcicrvys qplaqmvtsp lfkhmgsagt ytilpitnlr hlstkncplk iksnrseplq 61 fgdferqvpc srksgssknv qkrlyelrql ktvlsetfgv teyasffesl rnalhinncs 121 enekkkllyd iilhqhelyp evarkigfyl pgevhrwfwy hipksesfnh ylfllksdvl 181 lftsnyctrf tnrlikgtem erqlatfqif lhdetnikfi mekvlklhtf dslialvngl 241 vkaknfrfik vfiqallqkl eqhcysgkdg akqknlryvk fnntllyyll ksgnvelfik 301 tfqeelkfiv ssgllnhidg nehilnfpih hylnllrisn rqeelfnvis clqssplmky 361 klfkeflmge liasfqafrd pklvckylls sysskasani lnalgiwgwl yhsksttlta 421 ptlarelknk nnilpntmri gspvtvpilt elyrsllsss svslesgqfk nclldlyyky 481 ksflseeahk yrywrndtgi lnvflnyirf qareprlayn vlldfysqpf akkvvltttl 541 cpfsivaykn htltqaelse llqvmhkngv pltfkfcsam vmhyvkmrde kgarswynki 601 lfggfeirhm aliqiikdqg wpfpknfdet lltelvennn ikeptdstlf tdedmfeedg 661 kprfndddvn kctniiretl ksln // LOCUS NP_010638 864 aa linear PLN 30-JUN-2025 DEFINITION Sbe2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010638 VERSION NP_010638.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180659.3 REFERENCE 1 (residues 1 to 864) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 864) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 864) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 864) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 864) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 864) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 864) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 864) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 864) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12191. On Jul 30, 2012 this sequence version replaced NP_010638.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..864 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..864 /product="Sbe2p" /calculated_mol_wt="98841" Region 79..862 /region_name="SBE2" /note="cell-wall formation; pfam17076" /db_xref="CDD:293681" CDS 1..864 /gene="SBE2" /locus_tag="YDR351W" /coded_by="NM_001180659.3:1..2595" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:10679005]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10679005]" /note="Protein required for bud growth; involved in transport of cell wall components from the Golgi to the cell surface; SBE2 has a paralog, SBE22, that arose from the whole genome duplication" /db_xref="GeneID:851953" /db_xref="SGD:S000002759" ORIGIN 1 mtarrliniv pntskldplk eedsthlkqn qpkkfstkel mlseyterks cslplsksrs 61 gssasssttg sngknigtrr pssnldfnfa sqdvvknvlg nnnphvptak cirpisddsi 121 gtssteifss shsnttsdsl ctsdisseeg eianskmedn cffksmread hrsnitplkk 181 srpgsilqkt rtassadkti csmstittci psrqnsvstp klsrtvglpg ssnttnsiaa 241 sqtsfisend splkhhcmst atiqepklmp itktpyvhsn stsvilpykt tqltpsqryr 301 lrkeqndqsl rkaikmkekf yedqdvnlel qegdvdgsli wnipmaslst ssfltlskfn 361 rkemsldsar gdeeiliqen ncegkqhsss alcvdktfhq vhstrkhtsn ssntlkescl 421 dykelpptci pgispvsdsq yiqdtmknls qiylhsseki sksilsgrsr svqslplefk 481 eassqgmedl mlvsedklka vshfrpswlp pkdfkerklq dkqiyknidl asmeelqknk 541 erdekakkne qnkvkfqhll drgitrnssl selkkiiwet pliskvrlqi ysqllqsdnc 601 litkcfiesf eevmqllnkm dfpkdkefei rqliehdvqe kvfykngtdk qvvsdlmlll 661 qlksisqqgl vtgdemlfyh fltdqsfgtl ketwemvnli qmtcfseick ekydsrilnp 721 rgivahllrk defknefngg clnsntwwni lqrmdhklfm wvmdviivhn gqnfanypvk 781 meifkdkvwe yyrskkvivn ykilvsltvn vllnyhfgyd nlkhlsdldd khfciplyte 841 dsieeenlnn iftkwwlhyy rklr // LOCUS NP_010639 317 aa linear PLN 30-JUN-2025 DEFINITION Ypq2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010639 VERSION NP_010639.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180660.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12192. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..317 /product="Ypq2p" /calculated_mol_wt="35048" Region 11..71 /region_name="PQ-loop" /note="PQ loop repeat; pfam04193" /db_xref="CDD:461220" Region 184..239 /region_name="PQ-loop" /note="PQ loop repeat; pfam04193" /db_xref="CDD:461220" CDS 1..317 /gene="YPQ2" /locus_tag="YDR352W" /coded_by="NM_001180660.1:1..954" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:23169667]" /experiment="EXISTENCE:mutant phenotype:GO:0015174 basic amino acid transmembrane transporter activity [PMID:23169667]" /experiment="EXISTENCE:mutant phenotype:GO:0034488 basic amino acid transmembrane export from vacuole [PMID:23169667]" /experiment="EXISTENCE:mutant phenotype:GO:0034490 basic amino acid transmembrane import into vacuole [PMID:32776922]" /note="Putative vacuolar membrane transporter for cationic amino acids; involved in vacuolar export of arginine under nitrogen starvation conditions; appears to be inactive under nitrogen replete conditions; may contribute to amino acid homeostasis; vacuolar membrane protein; member of the PQ-loop family, containing seven transmembrane domains; homologous to the human lysosomal cationic amino acid exporter PQLC2; null mutant is functionally complemented by the rat PQLC2 vacuolar transporter" /db_xref="GeneID:851954" /db_xref="SGD:S000002760" ORIGIN 1 mscsngiwpt vsnlcgslsf ftsvislfpq iietyrdksv dglspyflla wlcgditsli 61 gakltgqllf qillaiyfll ndsfvcgqyy yygvlhenkl atvghepkpl lpelvengel 121 lreeedmiqg gssaesprss rrrsaitaal aiahtistas ayplnvgstq sqvgppgdgk 181 nsqlgtilsw igasfyvgar ipqliknynr kstdglspfl fattllcnit ynlsiftscr 241 fldnqnkref ivnelpfifg sagtiafdli yfyqyyilya tdmqlreler elyspeedsa 301 aqlvtertsl lsgetqt // LOCUS NP_010640 319 aa linear PLN 30-JUN-2025 DEFINITION thioredoxin-disulfide reductase TRR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010640 VERSION NP_010640.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180661.1 REFERENCE 1 (residues 1 to 319) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 319) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 319) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 319) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12193. Method: conceptual translation. FEATURES Location/Qualifiers source 1..319 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..319 /product="thioredoxin-disulfide reductase TRR1" /EC_number="1.8.1.9" /calculated_mol_wt="34107" Region 5..315 /region_name="TRX_reduct" /note="thioredoxin-disulfide reductase; TIGR01292" /db_xref="CDD:273540" CDS 1..319 /gene="TRR1" /locus_tag="YDR353W" /coded_by="NM_001180661.1:1..960" /experiment="EXISTENCE:direct assay:GO:0004791 thioredoxin-disulfide reductase (NADPH) activity [PMID:7961686]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18406344]" /experiment="EXISTENCE:direct assay:GO:0008198 ferrous iron binding [PMID:18406344]" /experiment="EXISTENCE:direct assay:GO:0045454 cell redox homeostasis [PMID:9571241]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:15051715]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:9571241]" /note="Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication" /db_xref="GeneID:851955" /db_xref="SGD:S000002761" ORIGIN 1 mvhnkvtiig sgpaahtaai ylaraeikpi lyegmmangi aaggqltttt eienfpgfpd 61 gltgselmdr mreqstkfgt eiitetvskv dlsskpfklw tefnedaepv ttdaiilatg 121 asakrmhlpg eetywqkgis acavcdgavp ifrnkplavi gggdsaceea qfltkygskv 181 fmlvrkdhlr astimqkrae knekieilyn tvaleakgdg kllnalrikn tkkneetdlp 241 vsglfyaigh tpatkivagq vdtdeagyik tvpgssltsv pgffaagdvq dskyrqaits 301 agsgcmaald aekyltsle // LOCUS NP_010641 380 aa linear PLN 30-JUN-2025 DEFINITION anthranilate phosphoribosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010641 VERSION NP_010641.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180662.3 REFERENCE 1 (residues 1 to 380) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 380) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 380) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 380) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12194. On Jul 30, 2012 this sequence version replaced NP_010641.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..380 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..380 /product="anthranilate phosphoribosyltransferase" /EC_number="2.4.2.18" /calculated_mol_wt="41243" Region 101..367 /region_name="Glycos_transf_3" /note="Glycosyl transferase family, a/b domain; pfam00591" /db_xref="CDD:459860" CDS 1..380 /gene="TRP4" /locus_tag="YDR354W" /coded_by="NM_001180662.3:1..1143" /experiment="EXISTENCE:direct assay:GO:0004048 anthranilate phosphoribosyltransferase activity [PMID:2428012]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000162 L-tryptophan biosynthetic process [PMID:10790693]" /note="Anthranilate phosphoribosyl transferase; transferase of the tryptophan biosynthetic pathway; catalyzes the phosphoribosylation of anthranilate; subject to the general control system of amino acid biosynthesis" /db_xref="GeneID:851956" /db_xref="SGD:S000002762" ORIGIN 1 mseatllsyt kkllasppql sstdlhdall vilsllqkcd tnsdeslsiy tkvssfltal 61 rvtkldhkae yiaeaakavl rhsdlvdlpl pkkdelhped gpvildivgt ggdgqntfnv 121 stsaaivasg iqglkickhg gkastsnsga gdligtlgcd mfkvnsstvp klwpdntfmf 181 llapffhhgm ghvskirkfl giptvfnvlg pllhpvshvn krilgvyske lapeyakaaa 241 lvypgsetfi vwghvgldev spigkttvwh idptsselkl ktfqlepsmf gleehelskc 301 asygpkenar ilkeevlsgk yhlgdnnpiy dyilmntavl yclsqghqnw kegiikaees 361 ihsgnalrsl ehfidsvssl // LOCUS NP_010643 944 aa linear PLN 30-JUN-2025 DEFINITION Spc110p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010643 VERSION NP_010643.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180664.3 REFERENCE 1 (residues 1 to 944) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 944) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 944) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 944) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12195. On Jul 30, 2012 this sequence version replaced NP_010643.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..944 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..944 /product="Spc110p" /calculated_mol_wt="111651" Region 196..>793 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 893..944 /region_name="Spc110_C" /note="Spindle pole body component 110 C-terminal domain; pfam18520" /db_xref="CDD:375946" CDS 1..944 /gene="SPC110" /locus_tag="YDR356W" /gene_synonym="NUF1; XCM1" /coded_by="NM_001180664.3:1..2835" /experiment="EXISTENCE:direct assay:GO:0005516 calmodulin binding [PMID:8886974|PMID:8247006]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8886974|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005822 inner plaque of spindle pole body [PMID:9215630|PMID:28331072]" /experiment="EXISTENCE:direct assay:GO:0005823 central plaque of spindle pole body [PMID:9215630|PMID:8886974]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:24842996|PMID:9384578]" /experiment="EXISTENCE:direct assay:GO:0065003 protein-containing complex assembly [PMID:24842996|PMID:20631709|PMID:27226487]" /experiment="EXISTENCE:direct assay:GO:0110120 gamma-tubulin complex localization to nuclear side of mitotic spindle pole body [PMID:9384578]" /experiment="EXISTENCE:genetic interaction:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:12836012]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:23468650]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:12836012]" /experiment="EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:7503995]" /experiment="EXISTENCE:mutant phenotype:GO:0044877 protein-containing complex binding [PMID:24842996]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:24842996]" /experiment="EXISTENCE:mutant phenotype:GO:0090063 positive regulation of microtubule nucleation [PMID:24842996]" /experiment="EXISTENCE:mutant phenotype:GO:1902440 protein localization to mitotic spindle pole body [PMID:8886974]" /experiment="EXISTENCE:physical interaction:GO:0110120 gamma-tubulin complex localization to nuclear side of mitotic spindle pole body [PMID:9384578]" /note="Inner plaque spindle pole body (SPB) component; gamma-tubulin small complex (gamma-TuSC) receptor that interacts with Spc98p to recruit the complex to the nuclear side of the SPB, connecting nuclear microtubules to the SPB; promotes gamma-TuSC assembly and oligomerization to initiate microtubule nucleation; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner; ortholog of human pericentrin (kendrin)" /db_xref="GeneID:851957" /db_xref="SGD:S000002764" ORIGIN 1 mdeashlpng slknmeftpv gfikskrntt qtqvvsptkv pnanngdene gpvkkrqrrs 61 iddtidstrl fseasqfdds fpeikanipp sprsgnvdks rkrnliddlk kdvpmsqplk 121 eqevrehqmk kerfdrales kllgkrhity ansdisnkel yineikslkh eikelrkekn 181 dtlnnydtle eetddlknrl qalekeldak nkivnsrkvd dhsgcieere qmerklaele 241 rklktvkdqv lelennsdvq slklrskede lknlmnelne lksnaeekdt qlefkknelr 301 krtnelnelk iksdemdlql kqkqneskrl kdelneletk fsengsqssa kenelkmlkn 361 kiaeleeeis tknsqliake gklaslmaql tqlesklnqr dsqlgsreee lkktndklqk 421 diriareetv skderiidlq kkvkqlendl fvikkthses ktitdneles kdklikilen 481 dlkvaqekys kmekelkere fnykiseskl edekttlnek isnlaaensq lknkiednst 541 athhmkenye kqleslrkdi eeykesakds edkieelkir iaensakvse krskdikqkd 601 eqisdltqnl klqedeissl ksiidrykkd fnqlkseqsn iqhdlnlqil nlenkliese 661 delkslrdsq kieienwkrk ynnlslendr lltekesasd kereisilnr kldemdkekw 721 nlqeskekyk relqkvitan drlrrekeel nensnnirim edkmtrikkn ylseitslqe 781 enrrleerli lnerrkdnds tmqlndiisy yklkyhsevr hnndlkvind ylnkvlalgt 841 rrlrldtrkg ehslnislpd ddeldrdyyn shvytryhdy eyplrfnlnr rgpyferrls 901 fktvallvla cvrmkriafy rrsddnrlri lrdriesssg risw // LOCUS NP_010644 122 aa linear PLN 30-JUN-2025 DEFINITION Cnl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010644 VERSION NP_010644.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180665.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12196. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..122 /product="Cnl1p" /calculated_mol_wt="13826" Region 17..103 /region_name="BLOC1_CNL1" /note="Biogenesis of lysosome-related organelles complex 1 subunit CNL1; cd24144" /db_xref="CDD:467944" CDS 1..122 /gene="CNL1" /locus_tag="YDR357C" /coded_by="NM_001180665.1:1..369" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]" /note="Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:851959" /db_xref="SGD:S000002765" ORIGIN 1 mqdnsshsre sasagddplg idkltvdydy llykmrdyvq siqldttelc kkqnevmvng 61 iientidkni akfkellekc dtlenhyeml nqlaiitdtf keriaeavnn ynslkkgask 121 sk // LOCUS NP_010645 557 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010645 VERSION NP_010645.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180666.1 REFERENCE 1 (residues 1 to 557) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 557) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 557) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 557) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12197. Method: conceptual translation. FEATURES Location/Qualifiers source 1..557 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..557 /product="ubiquitin-binding protein" /calculated_mol_wt="62189" Region 22..160 /region_name="VHS_GGA_fungi" /note="VHS (Vps27/Hrs/STAM) domain of fungal GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) proteins; cd16998" /db_xref="CDD:340795" Site order(23,27,32,62,66..67,69..72) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:340795" Site order(39..40,43,47,88..89) /site_type="other" /note="putative intraprotein/interprotein binding site [polypeptide binding]" /db_xref="CDD:340795" Site order(100..102,105,114..115,149,156,160) /site_type="other" /note="acidic-cluster-dileucine motif interaction site [polypeptide binding]" /db_xref="CDD:340795" Region 195..222 /region_name="GGA_N-GAT" /note="N-terminal extension of GAT domain; pfam18308" /db_xref="CDD:465702" Region 233..320 /region_name="GAT_GGA_fungi" /note="canonical GAT domain found in fungal ADP-ribosylation factor (Arf)-binding proteins (GGAs); cd14235" /db_xref="CDD:410583" Site order(242,245..246,249,252..253,262..263,265..266,269..270, 273) /site_type="other" /note="putative ubiquitin binding site [polypeptide binding]" /db_xref="CDD:410583" Region 443..555 /region_name="Alpha_adaptinC2" /note="Adaptin C-terminal domain; pfam02883" /db_xref="CDD:460735" CDS 1..557 /gene="GGA1" /locus_tag="YDR358W" /coded_by="NM_001180666.1:1..1674" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:10747088]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:15039776|PMID:20150893]" /experiment="EXISTENCE:genetic interaction:GO:0006896 Golgi to vacuole transport [PMID:10747088]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:15039776]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:10747088]" /experiment="EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:15039776]" /note="Golgi-localized protein with homology to gamma-adaptin; interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi; GGA1 has a paralog, GGA2, that arose from the whole genome duplication" /db_xref="GeneID:851960" /db_xref="SGD:S000002766" ORIGIN 1 mpqrieltse pvrkprstes sllrkiqrac rstlpepdlg lnldvadyin skqgatprea 61 vlaieklvnn gdtqaavfal slldvlvknc gysihlqisr keflndlvkr fpeqpplrys 121 kvqqmileai eewyqtickh asykddlqyi ndmhkllkyk gytfpkvgse nlavlrpndq 181 lrtpselqee qeraqaakle ellrsgkpdd lkeanklmki magfkddtkv avkqainnel 241 nklkrkadlf nemltsadep dleneaiqel ygdlksaqpk fkklieeerd ddalvsnlsk 301 fndlviqllk ryksikgmke eelnvpdtne pakelnlidf dddttantps vtspskslqp 361 fddllgdfnk vslsspkspq endtvvdilg dahskssgid lldfdsqpge sktalsaysn 421 sivlpnglln sssnskeita qsqrhilnqs dhlridyelt resmtklrlv ifysnissdp 481 itnfallvas pkgttlslqp qsgnmlqsns rdgikqiasv egisvnlgkp iklkwkanyc 541 tkgdskeesg ttslpti // LOCUS NP_010646 982 aa linear PLN 30-JUN-2025 DEFINITION Eaf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010646 VERSION NP_010646.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180667.3 REFERENCE 1 (residues 1 to 982) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 982) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 982) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 982) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 982) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 982) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 982) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 982) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 982) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12198. On Jul 30, 2012 this sequence version replaced NP_010646.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..982 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..982 /product="Eaf1p" /calculated_mol_wt="112371" Region 347..418 /region_name="HSA" /note="domain in helicases and associated with SANT domains; smart00573" /db_xref="CDD:214727" Site order(650,691..692,694..695,697..699,701..703) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238096" Region 650..>700 /region_name="Myb_DNA-bind_6" /note="Myb-like DNA-binding domain; pfam13921" /db_xref="CDD:372817" CDS 1..982 /gene="EAF1" /locus_tag="YDR359C" /gene_synonym="VID21" /coded_by="NM_001180667.3:1..2949" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15353583|PMID:15485911]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:18212047]" /note="Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1" /db_xref="GeneID:851962" /db_xref="SGD:S000002767" ORIGIN 1 mssrpssavp nsaslsedqs sdrskfpkad dliderdrkl telycvsrln qlleltdenk 61 lrkeidaflk kndirrgirf deaslpkllh taatpitkkk lkdvnlinvp nqrlsdskms 121 relpensenv svkseshfvp shdnsirenm mdslrpaekt ggmwnkrple stmggeeerh 181 ekrqkmqsqs lessnnsema slpisprppv pnalahytyy enieyppadp tevqpavkfk 241 dpliknimak eidtsdhyne nnvdaletvf llmndyipsk ipqalplael kymsqtlpli 301 nliprahkal ttniinnaln earitvvgsr ieelrrlglw slrqpkrfid pwkqhnthqn 361 illeeakwmq adfkeghkyk vaictamaqa ikdywtygei ccvkrktllp gkenklsddg 421 riseksgrps dtsrndsdis iagkddigii anvdditeke saaandnden gkneagaksd 481 fdfadgllsq egahdqiiss idtklllkkp ssssevvliq hevaassali eteeskkela 541 ppfklsifvd elntfektli qdlplyngin eerpkkddsl pfipisksvv slddngfykl 601 lerqlideep sisqlskrrg mfygnrrnhy lrppavpslr ylqnrtptiw lseddqelvk 661 nintygynwe lisahmthrl tysylsnier rtpwqcferf vqlnerfnfs dlkgprahsa 721 qqwlieahkf qqrqnrrisp lgvntesiqr ghrrlrwasm feairkcmkk rentprpnpt 781 qprkpldckn mkvptpaems llkaqrdeal rrdiqlrrtv knrlqqrqqq sqqahssraq 841 spipsngkss snlarngqas aprpnqkqyt eqdiiesysr klleqkpdig pemalkaakn 901 yyrtlreqqq qlkqhqiqqq rqqlqeessh vqqlqqlqpg sqapppkssp sqsslsnisn 961 insapriksp tpqeilqrfq kq // LOCUS NP_010648 283 aa linear PLN 30-JUN-2025 DEFINITION protein-transporting protein BCP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010648 VERSION NP_010648.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180669.3 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12199. On Jul 30, 2012 this sequence version replaced NP_010648.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..283 /product="protein-transporting protein BCP1" /calculated_mol_wt="32530" Region 48..241 /region_name="BCCIP" /note="pfam13862" /db_xref="CDD:464002" CDS 1..283 /gene="BCP1" /locus_tag="YDR361C" /coded_by="NM_001180669.3:1..852" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:27913624]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:27913624]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:12912920]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:12912920]" /note="Essential nuclear chaperone for ribosomal protein Rpl23p; involved in nuclear export of Mss4p; Mss4p is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport" /db_xref="GeneID:851963" /db_xref="SGD:S000002769" ORIGIN 1 mvqaiklndl knrkrknvee engsdeseid isstdsenee eqngeeeivn idfdffggnp 61 evdfhalknl lrqlfgpqes triqlsslad lilgspttti ktdgkesdpy cflsfvdfka 121 nhlsdyvkyl qkvdmrlstf fktmidsgnk ncalvlserl inmppevvpp lykitledva 181 talgddkhyd fyiivtrkye vnfdtdddtd sgkrnknkde rskkrvkade vdyfheedrf 241 fekyakihfe seakkgviss ymildheglv ksideletei stw // LOCUS NP_010649 672 aa linear PLN 30-JUN-2025 DEFINITION transcription factor TFIIIC subunit TFC6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010649 VERSION NP_010649.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180670.1 REFERENCE 1 (residues 1 to 672) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 672) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 672) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 672) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12200. Method: conceptual translation. FEATURES Location/Qualifiers source 1..672 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..672 /product="transcription factor TFIIIC subunit TFC6" /calculated_mol_wt="74578" CDS 1..672 /gene="TFC6" /locus_tag="YDR362C" /coded_by="NM_001180670.1:1..2019" /experiment="EXISTENCE:direct assay:GO:0000127 transcription factor TFIIIC complex [PMID:9418847|PMID:1474578]" /experiment="EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2649882|PMID:2404611]" /experiment="EXISTENCE:direct assay:GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding [PMID:2404611]" /experiment="EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:3633923|PMID:2183033|PMID:8464480|PMID:9418847]" /experiment="EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2183033]" /experiment="EXISTENCE:genetic interaction:GO:0006383 transcription by RNA polymerase III [PMID:9418847]" /note="Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110" /db_xref="GeneID:851964" /db_xref="SGD:S000002770" ORIGIN 1 mavipakkrg rprksvvaev pydslaspvs ensgskrprr naskkavanf aqlvhagrdd 61 vinttqvnnv ddtddddfvl ndegdgeesd nveiefenel estknevadl nssgsgasvr 121 psgrrntvqk lrlkknstkn mkssspgssl gqkgrpirll kdlssardki eriyglnkek 181 llllakvkeg fetsvfdfpf kniqpdspyf vcldppckke saynkvigdk nrtvyheink 241 tefenmiklr tkrlkllige vdaevstgdk iefpvlangk rrgfiynvgg lvtdiawlni 301 eentdigkdi qylavavsqy mdeplnehle mfdkekhssc iqifkmntst lhcvkvqtiv 361 hsfgevwdlk whegchaphl vgclsfvsqe gtinfleiid natdvhvfkm cekpsltlsl 421 adslittfdf lspttvvcgf kngfvaefdl tdpevpsfyd qvhdsyilsv staysdfedt 481 vvstvavdgy fyifnpkdia ttkttvsrfr gsnlvpvvyc pqiysyiysd gasslravps 541 raafavhplv srettitaig vsrlhpmvla gsadgsliit naarrllhgi knssatqksl 601 rlwkwdysik ddkyridssy evypltvndv skakidahgi nitctkwnet saggkcyafs 661 nsaglltley ls // LOCUS NP_010650 456 aa linear PLN 30-JUN-2025 DEFINITION Esc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010650 VERSION NP_010650.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180671.1 REFERENCE 1 (residues 1 to 456) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 456) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 456) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 456) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12201. Method: conceptual translation. FEATURES Location/Qualifiers source 1..456 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..456 /product="Esc2p" /calculated_mol_wt="52411" Region <265..357 /region_name="ATP-synt_Fo_b" /note="F-type ATP synthase, membrane subunit b; cl21478" /db_xref="CDD:473877" Region 382..454 /region_name="Ubl_SLD2_Esc2_like" /note="SUMO-like domain 2 (SLD2), structurally similar to a beta-grasp ubiquitin-like fold, found in Saccharomyces cerevisiae establishes silent chromatin protein 2 (Esc2p) and similar proteins; cd17080" /db_xref="CDD:340600" CDS 1..456 /gene="ESC2" /locus_tag="YDR363W" /coded_by="NM_001180671.1:1..1371" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:27694623]" /experiment="EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:26443850]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11090616]" /experiment="EXISTENCE:direct assay:GO:0032079 positive regulation of endodeoxyribonuclease activity [PMID:27694623]" /experiment="EXISTENCE:direct assay:GO:0033235 positive regulation of protein sumoylation [PMID:33446573]" /experiment="EXISTENCE:direct assay:GO:0070336 flap-structured DNA binding [PMID:26443850]" /experiment="EXISTENCE:direct assay:GO:0180016 SUMO ligase regulator activity [PMID:33446573]" /experiment="EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:19158388]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:18757937]" /experiment="EXISTENCE:genetic interaction:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:19158388]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:19158388]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:18757937]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11090616]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:19158388]" /experiment="EXISTENCE:mutant phenotype:GO:0032079 positive regulation of endodeoxyribonuclease activity [PMID:27694623]" /experiment="EXISTENCE:mutant phenotype:GO:0033235 positive regulation of protein sumoylation [PMID:23935535]" /note="SUMO-like domain protein; binds Holliday junctions and replication fork structures; stimulates the Mms4-Mus81 endonuclease in the resolution of sister chromatid junctions; role in recombination-mediated DNA damage tolerance by recruiting Rad51p; facilitate Elg1p binding to stalled replication forks; prevents toxic intermediate accumulation during replication-associated recombinational repair; role in silencing, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member" /db_xref="GeneID:851965" /db_xref="SGD:S000002771" ORIGIN 1 mtgdsrsise psinldpdnt sfsdensddf fmdnsydide idhsdesnrq svivdskvtv 61 ppskhstltl sdsedsdake qhqslsrsss knvniedite pkpdkpsgrt rgrsvmkesv 121 veinssesdl dedknfprsr srsrssirsi spagkykrqk ssllytyden ddffkelake 181 akksttiske stpdqrkrvy nikflskleg tinkavqvkv lgkyefskil paaldglmks 241 ykipkvmkdi ykvenvtlyw nnaklltfmt cnslhipqdf enevsdidvt ivskeyeknf 301 eatlesklke eeaalliker qemerklekk rneqeeseyr efeselknve etqeikendt 361 vmntkllqeg gslsgnsssm eevmrialmg qdnkkiyvhv rrstpfskia eyyriqkqlp 421 qktrvkllfd hdeldmneci adqdmededm vdviid // LOCUS NP_010651 89 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle lid subunit SEM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010651 VERSION NP_010651.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184328.3 REFERENCE 1 (residues 1 to 89) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 89) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 89) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 89) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12202. On Jul 30, 2012 this sequence version replaced NP_010651.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..89 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..89 /product="proteasome regulatory particle lid subunit SEM1" /calculated_mol_wt="10255" Region 28..84 /region_name="DSS1_Sem1" /note="proteasome complex subunit DSS1/Sem1; cd13768" /db_xref="CDD:259841" Site order(28..41,57..62,64..65,67,71,73..74,76..78,80..84) /site_type="other" /note="nuclear mRNA export protein (Thp1) interaction site [polypeptide binding]" /db_xref="CDD:259841" CDS 1..89 /gene="SEM1" /locus_tag="YDR363W-A" /gene_synonym="DSS1; HOD1" /coded_by="NM_001184328.3:1..270" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9927667]" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:15572408|PMID:15117943]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:15117943]" /experiment="EXISTENCE:direct assay:GO:0070390 transcription export complex 2 [PMID:19289793]" /experiment="EXISTENCE:genetic interaction:GO:0006406 mRNA export from nucleus [PMID:19061648]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:19061648]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15572408]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:9927667]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:23620289]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:15117943]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:19217412]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:10373512]" /experiment="EXISTENCE:mutant phenotype:GO:0072742 SAGA complex localization to transcription regulatory region [PMID:23599000]" /experiment="EXISTENCE:physical interaction:GO:0006406 mRNA export from nucleus [PMID:19061648]" /note="19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851967" /db_xref="SGD:S000007235" ORIGIN 1 mstdvaaaqa qskidltkkk neeinkksle eddefedfpi dtwangetik snavtqtniw 61 eenwddvevd ddftnelkae ldrykrenq // LOCUS NP_010652 455 aa linear PLN 30-JUN-2025 DEFINITION Cdc40p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010652 VERSION NP_010652.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180672.3 REFERENCE 1 (residues 1 to 455) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 455) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 455) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 455) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12203. On Jul 30, 2012 this sequence version replaced NP_010652.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..455 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..455 /product="Cdc40p" /calculated_mol_wt="51917" Region 154..408 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(160..161,180,184,190..191,204..205,222,227,233..234, 249,265,270,275..276,291..292,310,314,320..321,336..337, 352,357,363..364,379..380,400,402,408) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 166..204 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 210..247 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 252..290 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 297..332 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 339..378 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 386..422 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 429..453 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..455 /gene="CDC40" /locus_tag="YDR364C" /gene_synonym="PRP17; SLT15; SLU4" /coded_by="NM_001180672.3:1..1368" /experiment="EXISTENCE:direct assay:GO:0005681 spliceosomal complex [PMID:9769104]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:genetic interaction:GO:0000348 mRNA branch site recognition [PMID:15133121]" /experiment="EXISTENCE:genetic interaction:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:10999606]" /experiment="EXISTENCE:genetic interaction:GO:0000389 mRNA 3'-splice site recognition [PMID:15133121|PMID:10628969]" /experiment="EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:10999606]" /experiment="EXISTENCE:mutant phenotype:GO:0000386 second spliceosomal transesterification activity [PMID:10999606]" /note="Pre-mRNA splicing factor; important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression, particularly at the G1/S phase transition; required for DNA synthesis during mitosis and meiosis; has WD repeats; thermosensitivity of the cdc40 null mutant is functionally complemented by a chimeric construct containing the N-terminal 156 amino acids of yeast Cdc40p fused to the C-terminal two thirds (297 amino acids) of human CDC40" /db_xref="GeneID:851968" /db_xref="SGD:S000002772" ORIGIN 1 mglvdgydts sdsdlnfdeg ksvhekkngn lhedtsyeps snnihkrksh ftkselkrrr 61 ktrkgdgpwg swsssddets qasetqkedq difvhalaed nldseqieve evshfygkse 121 kdyqgrgyly ppndvdvdlr eerisfrcyl pkkvirnypg hpegttalkf lpktghlils 181 ggndhtikiw dfyhdyeclr dfqghnkpik alrftedcqs flsssfdrsv kiwdtetgkv 241 ktrlhlnstp advesrptnp hefivglsns kilhyddrvs enqglvqtyd hhlssilalk 301 yfpdgskfis ssedktvriw enqinvpikq isdtaqhsmp flnvhpsqny fcaqsmdnri 361 ysfslkpkyk rhpkkifkgh ssagygisla fsgdgryics gdsksrlftw dwntsrllnn 421 ikipgnkpit qvdwhpqets kvicsgaagk iyvcd // LOCUS NP_010653 628 aa linear PLN 30-JUN-2025 DEFINITION pre-rRNA-processing protein ESF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010653 VERSION NP_010653.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180673.1 REFERENCE 1 (residues 1 to 628) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 628) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 628) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 628) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12204. Method: conceptual translation. FEATURES Location/Qualifiers source 1..628 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..628 /product="pre-rRNA-processing protein ESF1" /calculated_mol_wt="72279" Region 1..608 /region_name="COG5638" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227925" CDS 1..628 /gene="ESF1" /locus_tag="YDR365C" /coded_by="NM_001180673.1:1..1887" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:15056729]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:15056729]" /note="Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels" /db_xref="GeneID:851969" /db_xref="SGD:S000002773" ORIGIN 1 magenpkkeg vdarfagiys dpkfkntktk dhkikldsrf skkdlevqhk skvdkygrki 61 knaqnnrele dfdkyfekea endedsevna ktvvdrarge vpddyvsssd eftssdsess 121 geseveseee neveienakp esgdisknla vvnldwdhvk sedlmitfss fvpkggkier 181 vaiypsefgk ermqreeveg ppkelfqkkn knktskkkkt ddsdsdmdig ikdlyeegda 241 dkdvdsralr qyqldrlryy yaivycsdtt tskaiydncd gteyestanm fdlryvpdgm 301 tfdddvrdec silpknyrph qfstdalqhs svkltwdetp adrvevakra ftqkeiddmd 361 fkaylasdsd esdgqvdeea knklkslvgd fgfnskketp ndedeevdme itftpalegg 421 nekssedkee ttiekirrke kerrkarkqk vkelkqqsek dkksklksvn kkhtndeeei 481 eknakskael ellmdddddt etqgtinnka hfnmneilrs ekekhkkgry qkkerivedt 541 ftpdledprf kevfedhdfa idptqpefkg tqamskilke rskrvknkkr klggsennmt 601 nnaddnedig nlvnklkkks ksskkvkv // LOCUS NP_058153 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058153 VERSION NP_058153.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184426.3 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12206. On Jul 30, 2012 this sequence version replaced NP_058153.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..440 /product="gag protein" /calculated_mol_wt="48822" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YDR365W-A" /coded_by="NM_001184426.3:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:851970" /db_xref="SGD:S000007400" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_058152 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058152 VERSION NP_058152.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184427.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12205. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198529" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YDR365W-B" /coded_by="join(NM_001184427.2:1..1305, NM_001184427.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:851971" /db_xref="SGD:S000007401" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivqy gdfywvskry llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp nsapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnylwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd eyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli qqcgmeevrg wscvfknsqv ticlfvddmv lfsknlnsnk 1441 riieklkmqy dtkiinlges deeiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkptk pdnklvaisd asygnqpyyk 1621 sqigniflln gkviggkstk asltctstte aeihavseai pllnnlshlv qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_010654 132 aa linear PLN 30-JUN-2025 DEFINITION Mor1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010654 VERSION NP_010654.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180674.3 REFERENCE 1 (residues 1 to 132) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 132) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 132) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 132) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12207. On Jul 30, 2012 this sequence version replaced NP_010654.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..132 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..132 /product="Mor1p" /calculated_mol_wt="15409" CDS 1..132 /gene="MOR1" /locus_tag="YDR366C" /coded_by="NM_001180674.3:1..399" /note="hypothetical protein" /db_xref="GeneID:851972" /db_xref="SGD:S000002774" ORIGIN 1 mvtigssslv lflffvvfvq itytalhrfs rllctffski ieegcvwynk khrfpnlyky 61 iyvyvyilhi cfekyvnvei ivgipllika iilgiqnile vllkdlgihk resailhnsi 121 niiiiilyvy ih // LOCUS NP_010655 221 aa linear PLN 30-JUN-2025 DEFINITION Kei1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010655 VERSION NP_010655.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180675.1 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12208. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..221 /product="Kei1p" /calculated_mol_wt="25353" Region 11..182 /region_name="Kei1" /note="Inositolphosphorylceramide synthase subunit Kei1; pfam08552" /db_xref="CDD:430069" CDS 1..221 /gene="KEI1" /locus_tag="YDR367W" /coded_by="NM_001180675.1:1..666" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:19726565]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14690591]" /experiment="EXISTENCE:mutant phenotype:GO:0006673 inositol phosphoceramide metabolic process [PMID:19726565]" /experiment="EXISTENCE:mutant phenotype:GO:0070917 inositol phosphoceramide synthase regulator activity [PMID:19726565]" /experiment="EXISTENCE:physical interaction:GO:0070916 inositol phosphoceramide synthase complex [PMID:19726565]" /note="Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene" /db_xref="GeneID:851973" /db_xref="SGD:S000002775" ORIGIN 1 mrsslltlpk sflgfmplyl aveivlgisi lnkcsgaygi lalftghpld fmqwiaylws 61 vftlivfsqg lylihkpnll vfsqicvlyt idtistcfft lwfttqwftl edtanidgnn 121 alqsnpistg kltergidis kqsatesyey tmtilitlvs lifrfyfnfi lasfvqellh 181 hpkylvdrdd veqnlknkpi wkrlwaksqk gcyklcknll e // LOCUS NP_010656 312 aa linear PLN 30-JUN-2025 DEFINITION trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010656 VERSION NP_010656.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180676.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12209. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..312 /product="trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1" /calculated_mol_wt="34624" Region 7..296 /region_name="AKR_AKR3A1-2" /note="AKR3A family of aldo-keto reductase (AKR); cd19117" /db_xref="CDD:381343" Site order(26..28,51,55..56,81,112..113,169..170,193,219..225, 235,247,262..267,270,273..274) /site_type="active" /note="putative active site [active]" /db_xref="CDD:381343" Site order(51,56,81,112) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381343" CDS 1..312 /gene="YPR1" /locus_tag="YDR368W" /coded_by="NM_001180676.1:1..939" /experiment="EXISTENCE:direct assay:GO:0004032 aldose reductase (NADPH) activity [PMID:11306085]" /experiment="EXISTENCE:direct assay:GO:0004090 carbonyl reductase (NADPH) activity [PMID:19016485]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019568 arabinose catabolic process [PMID:12271459]" /experiment="EXISTENCE:direct assay:GO:0042843 D-xylose catabolic process [PMID:12271459]" /experiment="EXISTENCE:direct assay:GO:0045149 acetoin metabolic process [PMID:33845171]" /experiment="EXISTENCE:direct assay:GO:0052588 diacetyl reductase ((S)-acetoin forming) (NAD+) activity [PMID:33845171]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:17919749]" /experiment="EXISTENCE:mutant phenotype:GO:0019568 arabinose catabolic process [PMID:12271459]" /note="NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant" /db_xref="GeneID:851974" /db_xref="SGD:S000002776" ORIGIN 1 mpatlknssa tlklntgasi pvlgfgtwrs vdnngyhsvi aalkagyrhi daaaiylnee 61 evgraikdsg vpreeifitt klwgteqrdp eaalnkslkr lgldyvdlyl mhwpvplktd 121 rvtdgnvlci ptledgtvdi dtkewnfikt welmqelpkt gktkavgvsn fsinnikell 181 espnnkvvpa tnqieihpll pqdeliafck ekgivveays pfgsanapll keqaiidmak 241 khgvepaqli iswsiqrgyv vlaksvnper ivsnfkiftl peddfktisn lskvhgtkrv 301 vdmkwgsfpi fq // LOCUS NP_010657 854 aa linear PLN 30-JUN-2025 DEFINITION Xrs2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010657 VERSION NP_010657.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180677.3 REFERENCE 1 (residues 1 to 854) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 854) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 854) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 854) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 854) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12210. On Jul 30, 2012 this sequence version replaced NP_010657.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..854 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..854 /product="Xrs2p" /calculated_mol_wt="96234" Region 1..99 /region_name="FHA" /note="forkhead associated (FHA) domain superfamily; cl00062" /db_xref="CDD:469597" Site order(31..32,47..48,50,76) /site_type="other" /note="phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438714" CDS 1..854 /gene="XRS2" /locus_tag="YDR369C" /coded_by="NM_001180677.3:1..2565" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:14522986]" /experiment="EXISTENCE:direct assay:GO:0003691 double-stranded telomeric DNA binding [PMID:17698079]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9845372]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:14522986]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:15721260]" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17698079]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:17698079]" /experiment="EXISTENCE:genetic interaction:GO:0006284 base-excision repair [PMID:20040573]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:15548595|PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:20040573]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380|PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:15548595]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:27173583]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:15548595]" /experiment="EXISTENCE:mutant phenotype:GO:0097552 mitochondrial double-strand break repair via homologous recombination [PMID:22214610]" /experiment="EXISTENCE:physical interaction:GO:0030870 Mre11 complex [PMID:9845372]" /note="FHA domain-containing component of the Mre11 complex; MRE11-RAD50-XRS2 complex is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling; FHA domain is required for activation of Tel1p" /db_xref="GeneID:851975" /db_xref="SGD:S000002777" ORIGIN 1 mwvvryqntl edgsisfisc clqafktysi grssknplii kndksisrqh itfkweinns 61 sdlkhsslcl vnkgkltsln kkfmkvgetf tinasdvlks tiielgttpi riefewinev 121 wnipphltqf rtmlseygis teisindipa nlmisdypks ednsirelya lvstipmkks 181 rflmelcntl lptsktnlkf demwndmisn peynvfdfdp nillskfmrl nnirvlttik 241 seprlssllr tfninlfafd nidslykyvd sleasteyli ltttdkkeng kilctiktml 301 tsiidgtlsa vinmkgassr tldngkfdqi segmstilkt srapeveasp vvskkrklnr 361 rrvlpldsld ffagglstkt lsenrsltda krlncgaesk tvisspniae adekhapflq 421 nalkptedig kksghsspga iivsspnlgt vntsedsldk slqshklpqp slpevagigs 481 qtissnsady etaavnsmdd aevtknfrvn hhqnieqpsk nirklsnysr eissplqenc 541 kspvkelsik eksgtphafv eaiqetknre vkrvkstive lkdeelseea inqlknlaiv 601 epsnnllrks fdsegnktsr ttekwenslm epewhkrknf ktfvkvrpks kahkeegknn 661 tqssdfirna aflitrnyvp lkkyskkdtt tkwgteened mfaltemerf gsntfmsdni 721 nsntiqkrsq alnrftneds snegeedsfs fsrcsgtaas vqplknkifi tdeddlgdid 781 dksdrlnhre nnrnlfvvke mnlrpnlsee cskqsrhsrs atsrsrgsfg asnngdgddd 841 dddgpkftfk rrkg // LOCUS NP_010658 442 aa linear PLN 30-JUN-2025 DEFINITION Dxo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010658 VERSION NP_010658.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180678.3 REFERENCE 1 (residues 1 to 442) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 442) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 442) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 442) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12211. On Jul 30, 2012 this sequence version replaced NP_010658.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..442 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..442 /product="Dxo1p" /calculated_mol_wt="50361" CDS 1..442 /gene="DXO1" /locus_tag="YDR370C" /coded_by="NM_001180678.3:1..1329" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0110155 NAD-cap decapping [PMID:33139726]" /experiment="EXISTENCE:genetic interaction:GO:0004534 5'-3' RNA exonuclease activity [PMID:35140172]" /experiment="EXISTENCE:genetic interaction:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:31913314]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:35140172]" /experiment="EXISTENCE:mutant phenotype:GO:0004534 5'-3' RNA exonuclease activity [PMID:35140172]" /experiment="EXISTENCE:mutant phenotype:GO:0110155 NAD-cap decapping [PMID:33139726]" /note="Cytoplasmic 5' exoribonuclease; transcriptomics wide distributive exonuclease; involved in cytoplasmic mRNA degradation, turnover of tRNA introns and processing of spliceosomal introns; required for the final 5'-end processing of 25S rRNA; minor contributor to No-Go Decay and the unfolded protein response; decapping protein involved in surveillance and removal of non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs); sequence similarity to Rai1p" /db_xref="GeneID:851976" /db_xref="SGD:S000002778" ORIGIN 1 msteqdavlg lakdleginl ltvpnlergh qsklckektt sdssssrkps qqrdnyrkrr 61 pklicipyts flhtgmhnfl tkpprdifhe skevalftng raytilrkdl ipnlkesiae 121 lyesslleak krkvpylghd lfanidefvp mtiseldsvs pcfsyienwi ldnpgkdfki 181 gkkftvvttr hhivdltmhl fnrrnrqtsl ivtymgagll sfcrnvkkds qmskegiysn 241 dpnmkkicys gfefenwvte nskvadltgs kcpifslves klseeiglli rcemdafnpv 301 setntelkcf aplsmhnsnh rrkllktwvq tgllpnsdim iglrdshsgq lldiqwysrd 361 llckkfnhpg lptnkkelny naqiavewch ycieaicklv eanisdysst kpesfeigid 421 tnnaivitkl kttprnvelf gm // LOCUS NP_010659 511 aa linear PLN 30-JUN-2025 DEFINITION putative chitinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010659 VERSION NP_010659.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180679.1 REFERENCE 1 (residues 1 to 511) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 511) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 511) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 511) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12212. Method: conceptual translation. FEATURES Location/Qualifiers source 1..511 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..511 /product="putative chitinase" /EC_number="3.2.1.14" /calculated_mol_wt="58987" Region 75..451 /region_name="GH18_chitinase" /note="The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; cd06548" /db_xref="CDD:119365" Site order(78,107,219,221,223,293,295..296,344,447) /site_type="active" /db_xref="CDD:119365" CDS 1..511 /gene="CTS2" /locus_tag="YDR371W" /coded_by="NM_001180679.1:1..1536" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008843 endochitinase activity [PMID:37150231]" /experiment="EXISTENCE:direct assay:GO:0035885 exochitinase activity [PMID:37150231]" /experiment="EXISTENCE:genetic interaction:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:18809304]" /note="Chitinase; contains both exochitinase and endochitinase activities in vitro with higher chitobiosidase activity; glycoside hydrolase GH18 family member with putative N-terminal transmembrane domain; functionally complements A. gossypii cts2 mutant sporulation defect" /db_xref="GeneID:851977" /db_xref="SGD:S000002779" ORIGIN 1 mvghsaqhrs ksslvshlli llifitiiie mclynkifkn qrsddirdnf nngghrvpsn 61 vqnhgthird eafisgvyys nwspykprfh fphdinlkqv shiyyaffki nsrtggient 121 dswsdlemnl ykslaiknse likessnnsv qnilplgcig elfylkntcs dkkfkvimsi 181 ggwsdsenfk iiikddkllq nfvdssvetm frlgfdgidl dwefpgnnes eprgylklvr 241 mlrlklnsle sqifgkrted hfqlsiaapa fkdklfylpi teidqyvdyw nmmtydyygs 301 wsettgyhsn lfsetelngn famhymidrf gvnsrklvlg maaygrsfhi kdnkfepfnq 361 ntvlinkifk gvgkptkeid kadgkegiwp yknlpkigti eqydpkyvsa ycfdeknsif 421 isydntksvk tkaeyvthnn lgggfwwesc geayanesrs linafneglh fnvsskpsif 481 qdvrvkkyyl nkygdggfls pylkhldsrk q // LOCUS NP_010660 345 aa linear PLN 30-JUN-2025 DEFINITION Vps74p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010660 VERSION NP_010660.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180680.1 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12213. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..345 /product="Vps74p" /calculated_mol_wt="39156" Region 69..289 /region_name="GPP34" /note="Golgi phosphoprotein 3 (GPP34); pfam05719" /db_xref="CDD:428605" CDS 1..345 /gene="VPS74" /locus_tag="YDR372C" /gene_synonym="API1; MNN3" /coded_by="NM_001180680.1:1..1038" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:18410729]" /experiment="EXISTENCE:direct assay:GO:0005797 Golgi medial cisterna [PMID:22553352]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18410729]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:20026658]" /experiment="EXISTENCE:genetic interaction:GO:0045053 protein retention in Golgi apparatus [PMID:32673164]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:18635803]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16582425]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:32673164|PMID:18410729]" /experiment="EXISTENCE:mutant phenotype:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:22553352]" /experiment="EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:20026658]" /experiment="EXISTENCE:physical interaction:GO:0019899 enzyme binding [PMID:18410729]" /note="Golgi PI4K effector, PtdIns4P sensor, and retention receptor; interacts with glycosyltransferases, and in the PtdIns4P-bound state mediates retention of these enzymes in the Golgi; PtdIns4P sensor that limits PI4K signaling and regulates lipid homeostasis, interacting with the catalytic domain of Sac1p, the major PtdIns4P phosphatase, directing dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; contributes to telomere function; ortholog of human GOLPH3" /db_xref="GeneID:851978" /db_xref="SGD:S000002780" ORIGIN 1 mstlqrrrvn radsgdtssi hssanntkgd kianiavdgd ddngtnkkia ydpeesklrd 61 niniptltlm eevllmglrd regylsfwnd sisyalrgci iielalrgki rilddsarkr 121 fdlserliev idssktgevl ldetlqlmkn deplsisnwi dllsgetwnl lkinyqlkqv 181 rerlakglvd kgvlrtemkn fflfdmathp iadasckeai krrvlsvlvs rnmelsyney 241 fpettsfkii rtlalicgsy ganvlenvlt tleyekrdka israeeimaq fsqypfdlek 301 etelgvsvnl nkevkeeien npghdlqlev iagvfevfsr mdmll // LOCUS NP_010661 190 aa linear PLN 30-JUN-2025 DEFINITION frequenin [Saccharomyces cerevisiae S288C]. ACCESSION NP_010661 VERSION NP_010661.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180681.3 REFERENCE 1 (residues 1 to 190) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 190) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 190) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 190) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12214. On Jul 30, 2012 this sequence version replaced NP_010661.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..190 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..190 /product="frequenin" /calculated_mol_wt="21880" Region 24..174 /region_name="FRQ1" /note="Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; COG5126" /db_xref="CDD:444056" CDS 1..190 /gene="FRQ1" /locus_tag="YDR373W" /coded_by="NM_001180681.3:1..573" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:17908202]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0098744 1-phosphatidylinositol 4-kinase activator activity [PMID:10559922]" /experiment="EXISTENCE:mutant phenotype:GO:0009966 regulation of signal transduction [PMID:12477731]" /note="N-myristoylated calcium-binding protein; regulatory subunit of Pik1p that recruits Pik1p to Golgi membranes and stimulates its 1-phosphatidylinositol 4-kinase activity; member of the recoverin/frequenin branch of the EF-hand superfamily; human NCS1 functionally complements the heat sensitivity of a frq1 ts mutant" /db_xref="GeneID:851979" /db_xref="SGD:S000002781" ORIGIN 1 mgaktsklsk ddltclkqst yfdrreiqqw hkgflrdcps gqlaredfvk iykqffpfgs 61 pedfanhlft vfdkdnngfi hfeefitvls ttsrgtleek lswafelydl nhdgyitfde 121 mltivasvyk mmgsmvtlne deatpemrvk kifklmdkne dgyitldefr egskvdpsii 181 galnlydgli // LOCUS NP_010662 306 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding phosphate metabolism regulator [Saccharomyces cerevisiae S288C]. ACCESSION NP_010662 VERSION NP_010662.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180682.3 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12215. On Jul 30, 2012 this sequence version replaced NP_010662.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..306 /product="mRNA-binding phosphate metabolism regulator" /calculated_mol_wt="35921" Region 155..291 /region_name="YTH" /note="YT521-B-like domain; pfam04146" /db_xref="CDD:461195" CDS 1..306 /gene="PHO92" /locus_tag="YDR374C" /gene_synonym="MRB1" /coded_by="NM_001180682.3:1..921" /experiment="EXISTENCE:direct assay:GO:0003730 mRNA 3'-UTR binding [PMID:24206186]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24206186]" /experiment="EXISTENCE:direct assay:GO:1990247 N6-methyladenosine-containing RNA reader activity [PMID:26318451|PMID:36422864|PMID:24269006]" /experiment="EXISTENCE:mutant phenotype:GO:0019220 regulation of phosphate metabolic process [PMID:24206186]" /experiment="EXISTENCE:mutant phenotype:GO:0043488 regulation of mRNA stability [PMID:24206186]" /note="N6-Methyladenosine (m6A) reader; co-transcriptionally recruited to specific methylated mRNAs during meiotic prophase, facilitating protein synthesis and subsequent decay of m6A modified transcripts, resulting in timely meiotic recombination; regulates PHO4 mRNA stability, binding to the 3'UTR in a phosphate-dependent manner; posttranscriptional regulator of phosphate and glucose metabolism; contains a conserved YTH domain with RNA-binding activity; human homolog YTHDF2 complements a null mutant" /db_xref="GeneID:851980" /db_xref="SGD:S000002782" ORIGIN 1 mnqiwstgpp nfyfnsewke nkrndrtied slreldglih slerthievq tnpklkndvt 61 alndinkken keeithenyt hqinsiplts snlnrhfsfs rdynqsdnsn nnyyreylsk 121 prylqqstke qtfneinkrk saaiippwln ipensrffvi kssslkhvkr sfyngiwsst 181 hfgnkrlsea ykklnsgakv flffsintsg rfcgvaemvs dlkmdldtsi wedeqkygka 241 fkvrwvivrd innrslkrfl ipsnemkpit hsrdtqeipy sigisiinlf ktqdsdifsf 301 ldetye // LOCUS NP_001032576 89 aa linear PLN 30-JUN-2025 DEFINITION Wip1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032576 VERSION NP_001032576.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184680.1 REFERENCE 1 (residues 1 to 89) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 89) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 89) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 89) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12216. Method: conceptual translation. FEATURES Location/Qualifiers source 1..89 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..89 /product="Wip1p" /calculated_mol_wt="10113" Region <41..86 /region_name="WIP1_HFD" /note="C-terminal histone fold domain of Saccharomyces cerevisiae W-like protein 1 (Wip1) and similar proteins; cd22575" /db_xref="CDD:439342" CDS 1..89 /gene="WIP1" /locus_tag="YDR374W-A" /coded_by="NM_001184680.1:1..270" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:22561346]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:22561346]" /experiment="EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:22561346]" /note="Kinetochore localized hypothetical protein; interacts with Cnn1p (CENP-T); orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-W and fission yeast new1" /db_xref="GeneID:3799971" /db_xref="SGD:S000113553" ORIGIN 1 mdtealanyl lrqlsldaee nkledllqrq nedqessqey nkklllacgf qailrkilld 61 artrataegl revypyhiea atqafldsq // LOCUS NP_010663 456 aa linear PLN 30-JUN-2025 DEFINITION bifunctional AAA family ATPase chaperone/translocase BCS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010663 VERSION NP_010663.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180683.1 REFERENCE 1 (residues 1 to 456) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 456) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 456) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 456) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12217. Method: conceptual translation. FEATURES Location/Qualifiers source 1..456 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..456 /product="bifunctional AAA family ATPase chaperone/translocase BCS1" /calculated_mol_wt="50977" Region 59..228 /region_name="BCS1_N" /note="This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein; smart01024" /db_xref="CDD:214980" Region 238..386 /region_name="RecA-like_BCS1" /note="Mitochondrial chaperone BCS1; cd19510" /db_xref="CDD:410918" Site order(268,270,272..274,320) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:410918" CDS 1..456 /gene="BCS1" /locus_tag="YDR375C" /coded_by="NM_001180683.1:1..1371" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8599931]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:22017868]" /experiment="EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:22017868]" /experiment="EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:22017868]" /experiment="EXISTENCE:mutant phenotype:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:24055101]" /experiment="EXISTENCE:mutant phenotype:GO:0051131 chaperone-mediated protein complex assembly [PMID:10508156]" /experiment="EXISTENCE:physical interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:22017868]" /note="Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane and delivers it to an assembly intermediate of respiratory Complex III; also required for assembly of the Qcr10p subunit; mutation is functionally complemented by human homolog BCS1L, linked to neonatal diseases" /db_xref="GeneID:851981" /db_xref="SGD:S000002783" ORIGIN 1 msdkpidiqy dkqatpnlsg vitpptnetg ndsvreklsk lvgdamsnnp yfaaggglmi 61 lgtglavars giikasrvly rqmivdleiq skdksyawfl twmakhpqrv srhlsvrtny 121 iqhdngsvst kfslvpgpgn hwirykgafi likrersakm idiangspfe tvtlttlyrd 181 khlfddilne akdialktte gktviytsfg pewrkfgqpk akrmlpsvil dsgikegild 241 dvydfmkngk wysdrgipyr rgyllygppg sgktsfiqal ageldynici lnlsennltd 301 drlnhlmnnm persillled idaafnkrsq tgeqgfhssv tfsgllnald gvtsseetit 361 fmttnhpekl daaimrpgri dykvfvgnat pyqvekmfmk fypgetdick kfvnsvkeld 421 itvstaqlqg lfvmnkdaph dalkmvsslr nanhif // LOCUS NP_010664 493 aa linear PLN 30-JUN-2025 DEFINITION NADPH-adrenodoxin reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010664 VERSION NP_010664.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180684.3 REFERENCE 1 (residues 1 to 493) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 493) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 493) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 493) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12218. On Jul 30, 2012 this sequence version replaced NP_010664.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..493 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..493 /product="NADPH-adrenodoxin reductase" /EC_number="1.18.1.6" /calculated_mol_wt="56106" Region 18..486 /region_name="PLN02852" /note="ferredoxin-NADP+ reductase; cl30539" /db_xref="CDD:357415" CDS 1..493 /gene="ARH1" /locus_tag="YDR376W" /coded_by="NM_001180684.3:1..1482" /experiment="EXISTENCE:direct assay:GO:0004324 ferredoxin-NADP+ reductase activity [PMID:9727014]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9727014]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:20534343]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:11035018]" /note="Oxidoreductase of the mitochondrial inner membrane; involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability" /db_xref="GeneID:851982" /db_xref="SGD:S000002784" ORIGIN 1 msfvqirhis sqinrktvsi vgsgpsgfyt ayhllkkspi plnvtiwekl pvpfglsryg 61 vapdhpevkn ceetfttcae efssptnqkh kfsfvggiti gkeillkell dnqdavilsy 121 gctgdrklni pgelgtkgvf ssrefvnwyn ghpdfakdkr ftdfdwskvs kvgiigngnv 181 alditrvlis nqideiwent disslalnll rrapvkdvkl iarrdfvhsk ftnkelrelw 241 elekygirgr idpkffqkem fdpskydraf nrrvemcsey lkpfnerskk nykkapppss 301 gydkfweldy lktplkinrd dfgainslsl cnnrlnedns lqplkdvnni mtykvdllit 361 slgyagvpmp efsklsigfd kdhiankqgr vltssgeifp hlyasgwirk gsqgviastm 421 qdafevgdrv iqdlvvsgal slensidlsn ikhttwkdwe rinkkellrg kkehktrskf 481 ltfeelwngv egi // LOCUS NP_010665 101 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit f [Saccharomyces cerevisiae S288C]. ACCESSION NP_010665 VERSION NP_010665.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180685.3 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12219. On Jul 30, 2012 this sequence version replaced NP_010665.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..101 /product="F1F0 ATP synthase subunit f" /calculated_mol_wt="11181" Region 7..93 /region_name="F1F0-ATPsyn_F" /note="Mitochondrial F1-F0 ATP synthase subunit F of fungi; pfam10791" /db_xref="CDD:431498" CDS 1..101 /gene="ATP17" /locus_tag="YDR377W" /coded_by="NM_001180685.3:1..306" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:9288937]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:9288937]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:9288937]" /note="Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis" /db_xref="GeneID:851983" /db_xref="SGD:S000002785" ORIGIN 1 mifkravstl ippkvvsskn igsapnakri anvvhfyksl pqgpapaika ntrlarykak 61 yfdgdnasgk plwhfalgii afgysmeyyf hlrhhkgaee h // LOCUS NP_010666 86 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit LSM6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010666 VERSION NP_010666.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180686.1 REFERENCE 1 (residues 1 to 86) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 86) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 86) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 86) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12220. On Nov 30, 2005 this sequence version replaced NP_010666.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..86 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..86 /product="U4/U6-U5 snRNP complex subunit LSM6" /calculated_mol_wt="9266" Region 14..82 /region_name="Sm_like" /note="Sm and related proteins; cl00259" /db_xref="CDD:469694" Site order(21,39,50,70..82) /site_type="other" /note="heptamer interface [polypeptide binding]" /db_xref="CDD:212462" Site order(24..28,32..42,46..50) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212462" Site order(27..28,32,34,40..41,46,48,70..80) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:212462" Site order(45..46,74,76) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:212462" Site 70..81 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212462" CDS 1..86 /gene="LSM6" /locus_tag="YDR378C" /coded_by="NM_001180686.1:1..261" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:18611963]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:15075370|PMID:10369684]" /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:10369684|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15075370]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:19806183]" /experiment="EXISTENCE:physical interaction:GO:0005732 sno(s)RNA-containing ribonucleoprotein complex [PMID:15075370]" /note="Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" /db_xref="GeneID:851984" /db_xref="SGD:S000002786" ORIGIN 1 msgkastegs vtteflsdii gktvnvklas gllysgrles idgfmnvals satehyesnn 61 nkllnkfnsd vflrgtqvmy iseqki // LOCUS NP_010667 1009 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein RGA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010667 VERSION NP_010667.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180687.1 REFERENCE 1 (residues 1 to 1009) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1009) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1009) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1009) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1009) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1009) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1009) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1009) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1009) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12221. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1009 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1009 /product="GTPase-activating protein RGA2" /calculated_mol_wt="113160" Region 13..67 /region_name="LIM1_Rga" /note="The first LIM domain of Rga GTPase-Activating Proteins; cd09394" /db_xref="CDD:188780" Site order(13,16,34,37,40,43,63,66) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:188780" Region 70..123 /region_name="LIM2_Rga" /note="The second LIM domain of Rga GTPase-Activating Proteins; cd09395" /db_xref="CDD:188781" Site order(70,73,92,95,98,101,119,122) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:188781" Region 815..1002 /region_name="RhoGAP" /note="GTPase-activator protein for Rho-like GTPases; smart00324" /db_xref="CDD:214618" Site order(826,872,876,966,969..970,992) /site_type="other" /note="GTPase interaction site" /db_xref="CDD:238090" Site 826 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:238090" CDS 1..1009 /gene="RGA2" /locus_tag="YDR379W" /coded_by="NM_001180687.1:1..3030" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:17981141|PMID:12455995]" /experiment="EXISTENCE:direct assay:GO:0032177 cellular bud neck split septin rings [PMID:18166650]" /experiment="EXISTENCE:genetic interaction:GO:0005096 GTPase activator activity [PMID:12455995]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:14517318|PMID:12455995]" /experiment="EXISTENCE:mutant phenotype:GO:0007264 small GTPase-mediated signal transduction [PMID:12455995]" /note="GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p; RGA2 has a paralog, RGA1, that arose from the whole genome duplication" /db_xref="GeneID:851985" /db_xref="SGD:S000002787" ORIGIN 1 msadpindqs slcvrcnksi assqvyeles kkwhdqcftc ykcdkklnad sdflvldigt 61 licydcsdkc tncgdkiddt aiilpssnea ycsncfrccr csnriknlky aktkrglccm 121 dchekllrkk qlllenqtkn sskedfpikl persvkrpls ptringksdv stnntaiskn 181 lvssnedqql tpqvlvsqer desslndnnd ndnskdreet sshartvsid dilnstlehd 241 snsieeqslv dnedyinkmg edvtyrllkp qranrdsivv kdpripnsns nanrffsiyd 301 keetdkddtd nkeneiivnt prnstdkits plnspmavqm neevepphgl altlseatke 361 nnkssqgiqt stsksmnhvs pitrtdtvem ktstssstlr lsdngsfsrp qtadnllphk 421 kvapspnkkl srsfslkskn fvhnlkskts emldpkhphh stsiqesdth sgwgvsstht 481 nirkskakkn pvsrgqsdst iyntlpqhgn ftvpefnhkk aqsslgsisk kqnsndtatn 541 rringsftss ssghhiamfr tpplesgplf krpslssesa hhrssslqts rstnalledd 601 stkvdatdes atslekdfyf teltlrklkl dvrelegtkk kllqdvenlr lakerllndv 661 dnltrekdkq sassresleq keniatsitv kspssnsdrk gsisnaspkp rfwkifssak 721 dhqvgdlesq qrspnsssgg ttniaqkeis spklirvhde lpspgkvpls pspkrldytp 781 dgshlygssl qarcayekst vpiiirccid riekddigln meglyrksgs qtlveeiene 841 faqnnslhsd tlspklnall nqdihavasv lkrylrklpd pvlsfsiyda lidlvrnnql 901 ierlplnndk fldspqkvti yemvlkslle ifkilpvehq evlkvlaahi gkvrrcsern 961 lmnlhnlslv fapslihdfd gekdivdmke rnyivefilg nyrdifkqa // LOCUS NP_076888 79 aa linear PLN 30-JUN-2025 DEFINITION Sdh6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_076888 VERSION NP_076888.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184471.3 REFERENCE 1 (residues 1 to 79) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 79) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 79) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 79) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12222. On Jul 30, 2012 this sequence version replaced NP_076888.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..79 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..79 /product="Sdh6p" /calculated_mol_wt="9221" Region 6..69 /region_name="Complex1_LYR_SDHAF1_LYRM8" /note="LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly factor 1 (SDHAF1) and similar proteins; cd20268" /db_xref="CDD:380763" CDS 1..79 /gene="SDH6" /locus_tag="YDR379C-A" /coded_by="NM_001184471.3:1..240" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0034553 mitochondrial respiratory chain complex II assembly [PMID:19465911]" /experiment="EXISTENCE:physical interaction:GO:0034553 mitochondrial respiratory chain complex II assembly [PMID:24954417]" /note="Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; member of the LYR protein family; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy" /db_xref="GeneID:851986" /db_xref="SGD:S000007605" ORIGIN 1 mpkrlsglqk evlhlyrasi rtahtkpken qvnfvnyihe efgkyrnlpr kdfttiehll 61 rvgnkkiatf shpeltnih // LOCUS NP_010668 635 aa linear PLN 30-JUN-2025 DEFINITION phenylpyruvate decarboxylase ARO10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010668 VERSION NP_010668.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180688.3 REFERENCE 1 (residues 1 to 635) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 635) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 635) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 635) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12223. On Jul 30, 2012 this sequence version replaced NP_010668.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..635 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..635 /product="phenylpyruvate decarboxylase ARO10" /EC_number="4.1.1.43" /EC_number="4.1.1.72" /EC_number="4.1.1.74" /EC_number="4.1.1.80" /calculated_mol_wt="71254" Region 28..622 /region_name="PDC1" /note="TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]; COG3961" /db_xref="CDD:443161" CDS 1..635 /gene="ARO10" /locus_tag="YDR380W" /coded_by="NM_001180688.3:1..1908" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006559 L-phenylalanine catabolic process [PMID:12902239]" /experiment="EXISTENCE:direct assay:GO:0050177 phenylpyruvate decarboxylase activity [PMID:12902239|PMID:21501384]" /experiment="EXISTENCE:genetic interaction:GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0000950 branched-chain amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0006552 L-leucine catabolic process [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0006559 L-phenylalanine catabolic process [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0006569 L-tryptophan catabolic process [PMID:12499363]" /experiment="EXISTENCE:mutant phenotype:GO:0000951 L-methionine catabolic process to 3-methylthiopropanol [PMID:16423070]" /experiment="EXISTENCE:mutant phenotype:GO:0006552 L-leucine catabolic process [PMID:10753893]" /experiment="EXISTENCE:mutant phenotype:GO:0016831 carboxy-lyase activity [PMID:10753893]" /note="Phenylpyruvate decarboxylase; catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway; involved in protein N-terminal Met and Ala catabolism" /db_xref="GeneID:851987" /db_xref="SGD:S000002788" ORIGIN 1 mapvtiekfv nqeerhlvsn rsatipfgey ifkrllsidt ksvfgvpgdf nlslleylys 61 psvesaglrw vgtcnelnaa yaadgysrys nkigclitty gvgelsalng iagsfaenvk 121 vlhivgvaks idsrssnfsd rnlhhlvpql hdsnfkgpnh kvyhdmvkdr vacsvayled 181 ietacdqvdn virdiykysk pgyifvpadf admsvtcdnl vnvprisqqd civypsenql 241 sdiinkitsw iyssktpail gdvltdrygv snflnklick tgiwnfstvm gksvidesnp 301 tymgqyngke glkqvyehfe lcdlvlhfgv dineinnghy tftykpnaki iqfhpnyirl 361 vdtrqgneqm fkginfapil kelykridvs klslqydsnv tqytnetmrl edptngqssi 421 itqvhlqktm pkflnpgdvv vcetgsfqfs vrdfafpsql kyisqgffls igmalpaalg 481 vgiamqdhsn ahinggnvke dykprlilfe gdgaaqmtiq elstilkcni pleviiwnnn 541 gytieraimg ptrsyndvms wkwtklfeaf gdfdgkytns tliqcpskla lkleelknsn 601 krsgiellev klgeldfpeq lkcmveaaal krnkk // LOCUS NP_010669 226 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding protein YRA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010669 VERSION NP_010669.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180689.1 REFERENCE 1 (residues 1 to 226) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 226) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 226) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12224. Method: conceptual translation. FEATURES Location/Qualifiers source 1..226 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..226 /product="RNA-binding protein YRA1" /calculated_mol_wt="24825" Region 78..156 /region_name="RRM_YRA1_MLO3" /note="RNA recognition motif (RRM) found in yeast RNA annealing protein YRA1 (Yra1p), yeast mRNA export protein mlo3 and similar proteins; cd12267" /db_xref="CDD:409711" CDS 1..226 /gene="YRA1" /locus_tag="YDR381W" /gene_synonym="SHE11" /coded_by="NM_001180689.1:1..681" /experiment="EXISTENCE:direct assay:GO:0000346 transcription export complex [PMID:11979277]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:11390651]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11979277]" /experiment="EXISTENCE:direct assay:GO:0071667 DNA/RNA hybrid binding [PMID:29954833]" /experiment="EXISTENCE:direct assay:GO:1990119 RNA helicase inhibitor activity [PMID:23721653]" /experiment="EXISTENCE:genetic interaction:GO:0006406 mRNA export from nucleus [PMID:11979277]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]" /note="Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member" /db_xref="GeneID:851988" /db_xref="SGD:S000002789" ORIGIN 1 msanldksld eiigsnkags nrarvggtrg ngprrvgkqv gsqrrslpnr rgpirkntra 61 ppnavarvak lldttrevkv nveglprdik qdavreffas qvggvqrvll synergqstg 121 manitfknge larraverfn gspidggrsr lrlnlivdpn qrpvksladr ikampqkggn 181 aprpvkrgpn rkaamaksqn kpkrekpakk sledldkema dyfekk // LOCUS NP_219495 114 aa linear PLN 30-JUN-2025 DEFINITION Coi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_219495 VERSION NP_219495.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184511.1 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12225. On Feb 2, 2004 this sequence version replaced NP_219495.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..114 /product="Coi1p" /calculated_mol_wt="12583" CDS 1..114 /gene="COI1" /locus_tag="YDR381C-A" /gene_synonym="MCO13" /coded_by="NM_001184511.1:1..345" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:28794267]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:28794267]" /experiment="EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:28794267]" /experiment="EXISTENCE:mutant phenotype:GO:0097250 mitochondrial respirasome assembly [PMID:28794267]" /note="Mitochondrial assembly factor; important for assembly of the mitochondrial respiratory chain bc1 complex (complex III), cytochrome oxidase (complex IV), and the complex III-complex IV supercomplex; embedded in the mitochondrial inner membrane, facing the intermembrane space" /db_xref="GeneID:851989" /db_xref="SGD:S000007650" ORIGIN 1 msnpfqnigk nllyisaagi asiyvvktiv karrdakfip kargnngevn eknyydnlaq 61 vkpgfpipkd ggdnidcsed hqlvrkskye gsglsavtrk rgdklgfldr rrne // LOCUS NP_010670 110 aa linear PLN 30-JUN-2025 DEFINITION ribosomal protein P2 RPP2B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010670 VERSION NP_010670.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180690.3 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12226. On Jul 30, 2012 this sequence version replaced NP_010670.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..110 /product="ribosomal protein P2 RPP2B" /calculated_mol_wt="10919" Region 1..110 /region_name="Ribosomal_P2" /note="Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins...; cd05833" /db_xref="CDD:100111" CDS 1..110 /gene="RPP2B" /locus_tag="YDR382W" /gene_synonym="RPL45; YPA1" /coded_by="NM_001180690.3:1..333" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:24391917]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:1601875]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:9559554]" /note="Ribosomal protein P2 beta; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm" /db_xref="GeneID:851990" /db_xref="SGD:S000002790" ORIGIN 1 mkylaaylll vqggnaapsa adikavvesv gaevdearin ellsslegkg sleeiiaegq 61 kkfatvptgg assaaagaag aaaggdaaee ekeeeakees dddmgfglfd // LOCUS NP_010671 238 aa linear PLN 30-JUN-2025 DEFINITION Nkp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010671 VERSION NP_010671.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180691.3 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12227. On Jul 30, 2012 this sequence version replaced NP_010671.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..238 /product="Nkp1p" /calculated_mol_wt="26845" CDS 1..238 /gene="NKP1" /locus_tag="YDR383C" /coded_by="NM_001180691.3:1..717" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:12408861]" /note="Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein fta4" /db_xref="GeneID:851991" /db_xref="SGD:S000002791" ORIGIN 1 mtdtynsisn fieneltall ssddylmddl agelpnevcr llkaqviekr kdamsrgkqd 61 llskeiydne selrasqsqq imelvgdipk yslgselrnr vegepqstsi erliedvlkl 121 pqmevadeee vevendlkvl seysnlrkdl ilkcqalqig esklsdilsq tnsinsltts 181 ikeasedddi seyfatyngk lvvaleemkl lleeavktfg nspekrekik kilselkk // LOCUS NP_010672 275 aa linear PLN 30-JUN-2025 DEFINITION putative ammonium permease ATO3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010672 VERSION NP_010672.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180692.1 REFERENCE 1 (residues 1 to 275) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 275) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 275) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 275) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12228. Method: conceptual translation. FEATURES Location/Qualifiers source 1..275 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..275 /product="putative ammonium permease ATO3" /calculated_mol_wt="29897" Region 77..273 /region_name="Gpr1_Fun34_YaaH" /note="GPR1/FUN34/yaaH family; pfam01184" /db_xref="CDD:426106" CDS 1..275 /gene="ATO3" /locus_tag="YDR384C" /coded_by="NM_001180692.1:1..828" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12966084]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0008519 ammonium channel activity [PMID:12429834]" /experiment="EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:12429834]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:12429834]" /experiment="EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:12429834]" /note="Plasma membrane protein, putative ammonium transporter; regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters" /db_xref="GeneID:851992" /db_xref="SGD:S000002792" ORIGIN 1 mtssasspqd lekgvntlen ietlpqqgsi agvsqgfpni qeiysdrdfi tlgsstyrrr 61 dllnaldrgd geegncakyt phqfanpvpl glasfslscl vlslinanvr gvtdgkwals 121 lfmffggaie lfagllcfvi gdtyamtvfs sfggfwicyg ygltdtdnlv sgytdptmln 181 nvigfflagw tvftflmlmc tlkstwglfl lltfldltfl llcigtfidn nnlkmaggyf 241 gilssccgwy slycsvvsps nsylafraht mpnap // LOCUS NP_010673 842 aa linear PLN 30-JUN-2025 DEFINITION elongation factor 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010673 VERSION NP_010673.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180693.1 REFERENCE 1 (residues 1 to 842) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 842) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 842) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 842) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12229. Method: conceptual translation. FEATURES Location/Qualifiers source 1..842 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..842 /product="elongation factor 2" /calculated_mol_wt="93158" Region 1..842 /region_name="PTZ00416" /note="elongation factor 2; Provisional" /db_xref="CDD:240409" CDS 1..842 /gene="EFT2" /locus_tag="YDR385W" /coded_by="NM_001180693.1:1..2529" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:16950777]" /note="Eukaryotic translation elongation factor 2 (eEF2, EF-2); also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication" /db_xref="GeneID:851993" /db_xref="SGD:S000002793" ORIGIN 1 mvaftvdqmr slmdkvtnvr nmsviahvdh gkstltdslv qragiisaak agearftdtr 61 kdeqergiti kstaislyse msdedvkeik qktdgnsfli nlidspghvd fssevtaalr 121 vtdgalvvvd tiegvcvqte tvlrqalger ikpvvvinkv drallelqvs kedlyqtfar 181 tvesvnvivs tyadevlgdv qvypargtva fgsglhgwaf tirqfatrya kkfgvdkakm 241 mdrlwgdsff npktkkwtnk dtdaegkple rafnmfildp ifrlftaimn fkkdeipvll 301 ekleivlkgd ekdlegkall kvvmrkflpa adallemivl hlpspvtaqa yraeqlyegp 361 addanciaik ncdpkadlml yvskmvptsd kgrfyafgrv fagtvksgqk vriqgpnyvp 421 gkkddlfika iqrvvlmmgr fvepiddcpa gniiglvgid qfllktgtlt tsetahnmkv 481 mkfsvspvvq vavevknand lpklveglkr lsksdpcvlt ymsesgehiv agtgelhlei 541 clqdlehdha gvplkisppv vayretvese ssqtalsksp nkhnriylka epideevsla 601 iengiinprd dfkararima ddygwdvtda rkiwcfgpdg ngpnlvidqt kavqylheik 661 dsvvaafqwa tkegpifgee mrsvrvnild vtlhadaihr gggqiiptmr ratyagflla 721 dpkiqepvfl veiqcpeqav ggiysvlnkk rgqvvseeqr pgtplftvka ylpvnesfgf 781 tgelrqatgg qafpqmvfdh wstlgsdpld ptskageivl aarkrhgmke evpgwqeyyd 841 kl // LOCUS NP_010674 632 aa linear PLN 30-JUN-2025 DEFINITION Mus81p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010674 VERSION NP_010674.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180694.3 REFERENCE 1 (residues 1 to 632) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 632) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 632) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 632) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12230. On Jul 30, 2012 this sequence version replaced NP_010674.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..632 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..632 /product="Mus81p" /calculated_mol_wt="72178" Region 132..224 /region_name="WH_MUS81" /note="winged helix domain found in crossover junction endonuclease MUS81 and similar proteins; cd21036" /db_xref="CDD:411029" Site 189..196 /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:411029" Region 347..494 /region_name="XPF_nuclease_Mus81" /note="XPF-like nuclease domain of Mus81; cd20074" /db_xref="CDD:410850" Site order(355,358,388) /site_type="other" /note="Mg binding site [ion binding]" /db_xref="CDD:410850" Site order(406,423,426..427,430,439,441,460..461,464..465, 467..468,472..476,478,482,486,489..490,493..494) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:410850" Site order(420..421,426,458,461..462,465) /site_type="other" /note="nucleic acid substrate binding site [nucleotide binding]" /db_xref="CDD:410850" CDS 1..632 /gene="MUS81" /locus_tag="YDR386W" /gene_synonym="SLX3" /coded_by="NM_001180694.3:1..1899" /experiment="EXISTENCE:direct assay:GO:0004520 DNA endonuclease activity [PMID:11641278]" /experiment="EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:25765656]" /experiment="EXISTENCE:direct assay:GO:0008821 crossover junction DNA endonuclease activity [PMID:17363897]" /experiment="EXISTENCE:direct assay:GO:0048476 Holliday junction resolvase complex [PMID:17363897]" /experiment="EXISTENCE:genetic interaction:GO:0000712 resolution of meiotic recombination intermediates [PMID:18691964]" /experiment="EXISTENCE:genetic interaction:GO:0000727 double-strand break repair via break-induced replication [PMID:23071463]" /experiment="EXISTENCE:genetic interaction:GO:0006265 DNA topological change [PMID:11139495]" /experiment="EXISTENCE:genetic interaction:GO:0007131 reciprocal meiotic recombination [PMID:11641278]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:23071463]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:10905349]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:11139495]" /note="Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA and DNA-protein cross-links; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); helix-hairpin-helix protein; phosphorylation of non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates function of Mms4p-Mus81p" /db_xref="GeneID:851994" /db_xref="SGD:S000002794" ORIGIN 1 melssnlkdl yiewlqelvd gltpkqeqlk iayekakrnl qnaegsfyyp tdlkkvkgig 61 ntiikrldtk lrnyckihhi spveapsltq tsstrppkrt ttalrsivns cendkneape 121 ekgtkkrktr kyipkkrsgg yaillsllel naiprgvske qiievagkys dhcmtpnfst 181 kefygawssi aalkkhslvl eegrpkrysl teegveltks lktadgisfp keneepneys 241 vtrnesseft anltdlrgey gkeeepcdin ntsfmlditf qdlstpqrlq nnvfkndrln 301 sqtnisshkl eevsddqtvp dsalkaksti krrryngvsy elwcsgdfev fpiidhreik 361 sqsdreffsr aferkgmkse irqlalgdii wvaknkntgl qcvlntiver krlddlalsi 421 rdnrfmeqkn rleksgcehk yylieetmsg nignmnealk talwvilvyy kfsmirtcns 481 detvekihal htvishhysq kdlivifpsd lkskddykkv llqfrrefer kggiecchnl 541 ecfqelmgkg dlktvgelti hvlmlvkgis lekavaiqei fptlnkilma yktcsseeea 601 kllmfnvlgd apgakkitks lsekiydafg kl // LOCUS NP_010675 555 aa linear PLN 30-JUN-2025 DEFINITION Cin10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010675 VERSION NP_010675.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180695.3 REFERENCE 1 (residues 1 to 555) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 555) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 555) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 555) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12231. On Jul 30, 2012 this sequence version replaced NP_010675.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..555 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..555 /product="Cin10p" /calculated_mol_wt="61378" Region 45..528 /region_name="MFS_HMIT_like" /note="H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; cd17360" /db_xref="CDD:340918" Site order(53,57,175,178..179,182,361..362,366..367,370..371, 396,453..454,457..458,462,484..485,488) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340918" CDS 1..555 /gene="CIN10" /locus_tag="YDR387C" /coded_by="NM_001180695.3:1..1668" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /note="Putative transporter; member of the sugar porter family; non-essential gene; overexpression results in elevated colony sectoring, an indicator of chromosomal instability" /db_xref="GeneID:851995" /db_xref="SGD:S000002795" ORIGIN 1 mstdesedvy sdlysiisqv tsntandieq lpyaltfkts lifvgatigg llfgydtgvi 61 sgvllslkpe dlslvvltdv qkelitssts vgsffgsila fpladrygrr itlaiccsif 121 ilaaigmaia rtltflicgr llvgiavgvs aqcvplflse ispsrirgfm ltlniiaitg 181 gqlvsyvias lmkeidnswr ylfalsaipa ilflsildfi pesprwsisk gdilytrdsl 241 rmlyptasty hvnskikqli ieldklrlye dasepllvqs qsvirymdss tsgtlsppni 301 krlssntert sntmssssay lsalrgpapn galasnkkkr hrmeprtira livgcmlmff 361 qqitgfnafm yyaaiifskf niknpllppi liastnfift ffamytmdsl grraillrti 421 limtvglllc svgfghdqvn lllisvviyv aayasamgsv pwtcveflpl nrrsfgasci 481 actnwltnaf vsmtylstin tigdentmli fafftvcawf fvyfwypevk glsleevgrv 541 fdngidvhyv frtyh // LOCUS NP_010676 482 aa linear PLN 30-JUN-2025 DEFINITION amphiphysin [Saccharomyces cerevisiae S288C]. ACCESSION NP_010676 VERSION NP_010676.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180696.1 REFERENCE 1 (residues 1 to 482) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 482) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 482) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 482) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12232. Method: conceptual translation. FEATURES Location/Qualifiers source 1..482 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..482 /product="amphiphysin" /calculated_mol_wt="52643" Region 29..245 /region_name="BAR_Rvs167p" /note="The Bin/Amphiphysin/Rvs (BAR) domain of Saccharomyces cerevisiae Reduced viability upon starvation protein 167 and similar proteins; cd07599" /db_xref="CDD:153283" Site order(38,41..42,46,48..49,52..53,55..56,66..67,69..70, 73..74,76..77,80,106,109..110,206,209..210,212,217, 220..221,223..224,227..228,231..232,234..235,238..239, 241..242) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153283" Region 425..478 /region_name="SH3" /note="Src Homology 3 domain superfamily; cl17036" /db_xref="CDD:473055" Site order(430,432,435,439,459..460,473,475..476) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212690" CDS 1..482 /gene="RVS167" /locus_tag="YDR388W" /coded_by="NM_001180696.1:1..1449" /experiment="EXISTENCE:direct assay:GO:0005516 calmodulin binding [PMID:27093085]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:32015451]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20610658|PMID:27093085]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10393809|PMID:16824951|PMID:16239147]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:10393809|PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0060988 lipid tube assembly [PMID:20610658]" /experiment="EXISTENCE:direct assay:GO:0097320 plasma membrane tubulation [PMID:27093085]" /experiment="EXISTENCE:genetic interaction:GO:0072741 protein localization to cell division site [PMID:23469085]" /experiment="EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:23469085]" /experiment="EXISTENCE:mutant phenotype:GO:0005516 calmodulin binding [PMID:27093085]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8590801|PMID:27093085]" /experiment="EXISTENCE:mutant phenotype:GO:0008289 lipid binding [PMID:27093085]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:8590801]" /experiment="EXISTENCE:mutant phenotype:GO:0097320 plasma membrane tubulation [PMID:27093085]" /experiment="EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:23469085]" /experiment="EXISTENCE:physical interaction:GO:0008092 cytoskeletal protein binding [PMID:10388809]" /experiment="EXISTENCE:physical interaction:GO:0016192 vesicle-mediated transport [PMID:15802519]" /experiment="EXISTENCE:physical interaction:GO:1990528 Rvs161p-Rvs167p complex [PMID:20610658]" /note="Calmodulin-binding actin-associated protein; roles in endocytic membrane tabulation and constriction, and exocytosis; N-BAR domain protein that interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin; necessary for efficient trafficking of CoQ6 to mitochondria" /db_xref="GeneID:851996" /db_xref="SGD:S000002796" ORIGIN 1 msfkgftkav srapqsfrqk fkmgeqtedp vyedaerrfq eleqetkkls eeskrystav 61 ngmlthqigf aksmeeifkp isgkmsdpna tipednpqgi easeqyraiv aelqetlkpd 121 lalveekivt pcqellkiit yirkmatkrn hkkldldrhl ntynkhekkk eptakdeerl 181 ykaqaqveva qqeydyyndl lktqlpilfs leaefvkplf vsfyfmqlni fytlynrlqd 241 mkipyfdlns divesyiakk gnveeqtdal tithfklgys kaklemtrrk ygvataegsp 301 vsgassgvgy gagydpatat sptptgygyg aaapsyaaqp aaqygtaaav gtaaavgtaa 361 gaaagavpgt ypqyaaaqsp pltglgfqqs pqqqqgpppa ysnpltspva gtpaaavaaa 421 pgvetvtaly dyqaqaagdl sfpagaviei vqrtpdvnew wtgryngqqg vfpgnyvqln 481 kn // LOCUS NP_010677 654 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein SAC7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010677 VERSION NP_010677.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180697.1 REFERENCE 1 (residues 1 to 654) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 654) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 654) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 654) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12233. Method: conceptual translation. FEATURES Location/Qualifiers source 1..654 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..654 /product="GTPase-activating protein SAC7" /calculated_mol_wt="73498" Region 122..393 /region_name="RhoGAP_fSAC7_BAG7" /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of...; cd04396" /db_xref="CDD:239861" Site order(173,214,218,353,356..357,379) /site_type="other" /note="putative GTPase interaction site [polypeptide binding]" /db_xref="CDD:239861" Site 173 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:239861" CDS 1..654 /gene="SAC7" /locus_tag="YDR389W" /coded_by="NM_001180697.1:1..1965" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:9038344]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:23878277]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:9038344|PMID:2183030]" /experiment="EXISTENCE:genetic interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:9038344]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:12949174|PMID:10625705]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:10625705]" /note="GTPase activating protein (GAP) for Rho1p; regulator of a Tor2p-mediated, Rho1p GTPase switch that controls organization of the actin cytoskeleton; negative regulator of the RHO1-PKC1-MAPK cell integrity (CWI) and membrane fluidity homeostasis signaling pathways; potential Cdc28p substrate; SAC7 has a paralog, BAG7, that arose from the whole genome duplication" /db_xref="GeneID:851997" /db_xref="SGD:S000002797" ORIGIN 1 mpnntlkqgs kienvspskg hvpsfwkqfi nnpksmssen itvprsptsl srnaqpttlk 61 rpplssrpys yntptkdrks fsksakqnnn nnnansgtsp haefknyrdm flsnrngftg 121 rvfgvtlaes lsvasaeviv qselvsfgri pivvakcgay lkangletsg ifriagngkr 181 vkalqyifss ppdygtkfnd wetytvhdva sllrrylnnl aepliplsly eqfrnplrsr 241 prilrhmlth evshpnankt nnvtvkssrq nynddgandg diekedakdd eekrrrkirh 301 krrltrdira aikeyeelfv tlsndtkqlt iylldllslf arqsqfnlms grnlaaifqp 361 silshpqhdm dpkeyelsrl vveflieysy kllphllkla kreqqerlst enkknngdkq 421 ktdpieipki tssdsppivs snknppaidn nnkldhttls pistsipens sdlqtskmlk 481 ppkqrrphsk sfgstpvppd viasnkrrts lfpwlhkpgi lsdtgdngdl tateaegddy 541 eeenvdpygq spssvhsgsl pkqhylpipr mnrslsgnst nssfntrpis miltsgndns 601 adqlellsnt hsnnersnal plteddgder nsrsrkresw fqrltsrsgs anra // LOCUS NP_010678 636 aa linear PLN 30-JUN-2025 DEFINITION E1 ubiquitin-activating protein UBA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010678 VERSION NP_010678.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180698.3 REFERENCE 1 (residues 1 to 636) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 636) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 636) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 636) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12234. On Jul 30, 2012 this sequence version replaced NP_010678.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..636 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..636 /product="E1 ubiquitin-activating protein UBA2" /calculated_mol_wt="71128" Region 23..438 /region_name="Uba2_SUMO" /note="Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...; cd01489" /db_xref="CDD:238766" Site order(28,30,32,52,54,63,76,119,125) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:238766" Site order(30,32,120..121,126,145..146,150..151,165,169..170) /site_type="other" /note="putative substrate interface [chemical binding]" /db_xref="CDD:238766" Site order(162,165,435,438) /site_type="other" /note="putative zinc binding site [ion binding]" /db_xref="CDD:238766" Site 177 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:238766" Region 183..>370 /region_name="UBA_E1_SCCH" /note="Ubiquitin-activating enzyme, SCCH domain; pfam10585" /db_xref="CDD:463157" Region 453..518 /region_name="UAE_UbL" /note="Ubiquitin/SUMO-activating enzyme ubiquitin-like domain; cl39046" /db_xref="CDD:476859" CDS 1..636 /gene="UBA2" /locus_tag="YDR390C" /gene_synonym="UAL1" /coded_by="NM_001180698.3:1..1911" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7629121]" /experiment="EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:9312010]" /experiment="EXISTENCE:direct assay:GO:0019948 SUMO activating enzyme activity [PMID:9312010]" /experiment="EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:9312010]" /experiment="EXISTENCE:mutant phenotype:GO:0019948 SUMO activating enzyme activity [PMID:9312010]" /experiment="EXISTENCE:physical interaction:GO:0031510 SUMO activating enzyme complex [PMID:9312010]" /note="Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability" /db_xref="GeneID:851998" /db_xref="SGD:S000002798" ORIGIN 1 mpretslvti igedsykklr ssrcllvgag gigsellkdi ilmefgeihi vdldtidlsn 61 lnrqflfrqk dikqpkstta vkavqhfnns klvpyqgnvm distfplhwf eqfdiifnal 121 dnlaarryvn kisqflslpl iesgtagfdg ymqpiipgkt ecfectkket pktfpvctir 181 stpsqpihci vwaknflfnq lfasetsgne ddnnqdwgtd daeeikrikq etnelyelqk 241 iiisrdasri peilnklfiq dinkllaien lwktrtkpvp lsdsqintpt ktaqsasnsv 301 gtiqeqisnf initqklmdr ypkeqnhief dkddadtlef vataanirsh ifnipmksvf 361 dikqiagnii paiattnaiv agasslislr vlnllkyapt tkytdlnmaf takasnlsqn 421 rylsnpklap pnkncpvcsk vcrgviklss dclnkmklsd fvvlirekys ypqdisllda 481 snqrllfdyd fedlndrtls einlgngsii lfsdeegdtm irkaielfld vddelpcntc 541 slpdvevpli kannspskne eeeknekgad vvattnshgk dgivilddde geitidaepi 601 ngskkrpvdt eiseapsnkr tklvneptns diveld // LOCUS NP_010679 232 aa linear PLN 30-JUN-2025 DEFINITION Iat4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010679 VERSION NP_010679.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180699.3 REFERENCE 1 (residues 1 to 232) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 232) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 232) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 232) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12235. On Jul 30, 2012 this sequence version replaced NP_010679.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..232 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..232 /product="Iat4p" /calculated_mol_wt="26143" CDS 1..232 /gene="IAT4" /locus_tag="YDR391C" /coded_by="NM_001180699.3:1..699" /experiment="EXISTENCE:direct assay:GO:0004059 aralkylamine N-acetyltransferase activity [PMID:40344241]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0030187 melatonin biosynthetic process [PMID:40344241]" /note="Indolamine N-Acetyltransferase; utilizes arylalkylamine substrates including 5-methoxytryptamine, tryptamine and serotonin, metabolites involved in metatonin biosynthesis; possible role in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /db_xref="GeneID:852000" /db_xref="SGD:S000002799" ORIGIN 1 msfenklptp lenndakghm vctlnkttda rraaetlsia fsnspafhfi ckkilnipla 61 ekvptrtitt diispfldsp ygeisevntf davavwslpp hvpkarsnda kfnkdfiddl 121 narvkqvipn ginyyylfci gknlnekgir gsvrtifeey krradeenca ivleaiaeha 181 ksvyeyfgfr nymtfkygec evdsngncdp ngegftaylm iyhkdgnkvl ke // LOCUS NP_010680 337 aa linear PLN 30-JUN-2025 DEFINITION transcriptional regulator SPT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010680 VERSION NP_010680.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180700.1 REFERENCE 1 (residues 1 to 337) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 337) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 337) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 337) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12236. Method: conceptual translation. FEATURES Location/Qualifiers source 1..337 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..337 /product="transcriptional regulator SPT3" /calculated_mol_wt="38669" Region 5..96 /region_name="TFIID-18kDa" /note="Transcription initiation factor IID, 18kD subunit; pfam02269" /db_xref="CDD:190265" Site order(34..35,37..38,41,45,48,50,52..54,66,69..70) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467051" CDS 1..337 /gene="SPT3" /locus_tag="YDR392W" /coded_by="NM_001180700.1:1..1014" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426|PMID:9224714]" /experiment="EXISTENCE:direct assay:GO:0001403 invasive growth in response to glucose limitation [PMID:12072450]" /experiment="EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:11485989]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0007124 pseudohyphal growth [PMID:12072450]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:mutant phenotype:GO:0003712 transcription coregulator activity [PMID:9858534]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:12370284]" /note="Subunit of the SAGA and SAGA-like transcriptional regulatory complexes; interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters; role in preventing L-A mycovirus pathogenesis; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852001" /db_xref="SGD:S000002800" ORIGIN 1 mmdkhkyrve iqqmmfvsge indppvetts liedivrgqv ieillqsnkt ahlrgsrsil 61 pedviflirh dkakvnrlrt ylswkdlrkn akdqdasagv asgtgnpgag geddlkkagg 121 gekdekdggn mmkvkksqik lpwelqfmfn ehplennddn ddmdederea nivtlkrlkm 181 addrtrnmtk eeyvhwsdcr qasftfrknk rfkdwsgisq ltegkphddv idilgfltfe 241 ivcsltetal kikqreqvlq tqkdksqqss qdntnfefas stlhrkkrlf dgpenvinpl 301 kprhieeawr vlqtidmrhr altnfkggrl sskpiim // LOCUS NP_010681 456 aa linear PLN 30-JUN-2025 DEFINITION She9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010681 VERSION NP_010681.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180701.1 REFERENCE 1 (residues 1 to 456) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 456) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 456) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 456) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12237. Method: conceptual translation. FEATURES Location/Qualifiers source 1..456 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..456 /product="She9p" /calculated_mol_wt="53440" Region 147..344 /region_name="She9_MDM33" /note="She9 / Mdm33 family; pfam05546" /db_xref="CDD:428516" CDS 1..456 /gene="SHE9" /locus_tag="YDR393W" /gene_synonym="MDM33" /coded_by="NM_001180701.1:1..1371" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12591915]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266]" /experiment="EXISTENCE:mutant phenotype:GO:0007007 inner mitochondrial membrane organization [PMID:12591915]" /note="Protein required for normal mitochondrial morphology; localized to mitochondrial inner membrane; may be involved in fission of the inner membrane; forms a homo-oligomeric complex; human structural ortholog CCDC51 alleviates the mitochondrial morphology defects of the null mutant" /db_xref="GeneID:852002" /db_xref="SGD:S000002801" ORIGIN 1 mlryygatrn lplvfsinkl mlrassftrp fhyssyslqn gdtpdkgstn kneirtpnna 61 vwkenielqw qhlkkklnel ysrfnfhrdq lsfqvnkakk siqeanrkls eqeneindsr 121 lnynkdelts akieglpser eqhrkkwsrk lefyfdslqe tlftatraln dvtgysgiqk 181 lkssislmek kleatkkehk lfkaqyanai deraqsqrev nellqrqsaw sssdlerftq 241 lykndalnar qeqelknkvk eieskeeqln ddlyrailtr yheeqiwsdk irrtstwgtf 301 ilmgmniflf ivlqlllepw krkrlvgsfe dkvksalney akeqnmkmdk llpgkssevt 361 dqgntensiv eehieqrgec kintaeidrp evataetttt emksfrdiwe rikalfvtlk 421 siqyrkldap lvfdtlefyl ysislvsmti lvsgli // LOCUS NP_010682 428 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle base subunit RPT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010682 VERSION NP_010682.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180702.3 REFERENCE 1 (residues 1 to 428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 428) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12238. On Jul 30, 2012 this sequence version replaced NP_010682.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..428 /product="proteasome regulatory particle base subunit RPT3" /calculated_mol_wt="47763" Region 46..428 /region_name="PTZ00454" /note="26S protease regulatory subunit 6B-like protein; Provisional" /db_xref="CDD:240423" CDS 1..428 /gene="RPT3" /locus_tag="YDR394W" /gene_synonym="YNT1; YTA2" /coded_by="NM_001180702.3:1..1287" /experiment="EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626|PMID:11742986]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9724628]" /experiment="EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:19843524]" /experiment="EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19412160]" /note="ATPase of the 19S regulatory particle of the 26S proteasome; one of ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B" /db_xref="GeneID:852003" /db_xref="SGD:S000002802" ORIGIN 1 meelgivtpv ekaveekpav ksyasllaql ngtvnnnsal snvnsdiyfk lkklekeyel 61 ltlqedyikd eqrhlkrelk raqeevkriq svplvigqfl epidqntgiv ssttgmsyvv 121 rilstldrel lkpsmsvalh rhsnalvdil ppdsdssisv mgenekpdvt yadvggldmq 181 kqeireavel plvqadlyeq igidpprgvl lygppgtgkt mlvkavanst kaafirvngs 241 efvhkylgeg prmvrdvfrl arenapsiif idevdsiatk rfdaqtgsdr evqriliell 301 tqmdgfdqst nvkvimatnr adtldpallr pgrldrkief pslrdrrerr lifgtiaskm 361 slapeadlds liirndslsg aviaaimqea glravrknry vilqsdleea yatqvktdnt 421 vdkfdfyk // LOCUS NP_010683 944 aa linear PLN 30-JUN-2025 DEFINITION Sxm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010683 VERSION NP_010683.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180703.3 REFERENCE 1 (residues 1 to 944) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 944) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 944) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 944) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12239. On Jul 30, 2012 this sequence version replaced NP_010683.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..944 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..944 /product="Sxm1p" /calculated_mol_wt="108274" Region 3..940 /region_name="SXM1" /note="Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]; COG5656" /db_xref="CDD:227943" CDS 1..944 /gene="SXM1" /locus_tag="YDR395W" /gene_synonym="KAP108" /coded_by="NM_001180703.3:1..2835" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9238021]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9238021]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:9412461]" /experiment="EXISTENCE:genetic interaction:GO:0006406 mRNA export from nucleus [PMID:9238021]" /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:9412461]" /experiment="EXISTENCE:physical interaction:GO:0061608 nuclear import signal receptor activity [PMID:9412461]" /note="Nuclear transport factor (karyopherin); involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1" /db_xref="GeneID:852004" /db_xref="SGD:S000002803" ORIGIN 1 mvqeqailsc ieqtmvadak iikeaeqqlf efqkqpgfts fllnivsddn falnvrlssa 61 iylknkihrs wdtkredgik adeklsiker lietlvknce nnhirpilte tingilvgqe 121 dwdlapiikn llssgdasyi ypgllllfql ckahrwdmvg srdyidsvie elfpivegia 181 snigsqtdyr sneilylilk sfkyaclnnl pqyfsqperi mswvqlhlyl cskplpvevm 241 eldpadrsld krvkvnkwgf gnlnrflqry nkitkaitke fidyifntiv piilreffkd 301 ieawgnnslw lsdsslyfli sflekcvtid qlypliephl qiifenvifp clcaneqsie 361 lleddqeeyt rryfdinreg stpdaasadf ifligskrpe klnnilpfin diftrfdans 421 sdinmafkee galrtlsnlf sfidepsvle nifghfivpl lsqdkymflv arsletialy 481 seefkdmnil sqlfeltytn flnsnvlpvq ieaadaikcl ivsnpqihpa vsahvpgmme 541 kllklskife idilsevmea lverfsdels pfakdlasnl veqflriaqa lvenpsetys 601 asdqeqeiqa sgllqtmttm vmsmnkvpli eslapvvkfv vlhaqisfit eavdlldalt 661 isshllynqi appiwellhd ildsfqtyam dyfeaysiff etivmtgfpq dqtyvqplle 721 ilsaklesev dydiehvmqi lmyfalsmrd iplfskaikv stndelglds kcivklglan 781 lfakpietlq imenegftin fftnwfnekf ysvfaiklqv lviltllkmp evpnsvspll 841 nnltnklvel tlslpkairn rdavtegksl egdltpeeee eyfiecdddm ketvldqinv 901 fqevhtffkn lqnedagkye kiinyldesk rdslqvilef vsqh // LOCUS NP_010685 146 aa linear PLN 30-JUN-2025 DEFINITION negative cofactor 2 transcription regulator complex subunit NCB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010685 VERSION NP_010685.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180705.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12240. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..146 /product="negative cofactor 2 transcription regulator complex subunit NCB2" /calculated_mol_wt="16519" Region 1..146 /region_name="COG5150" /note="Class 2 transcription repressor NC2, beta subunit (Dr1) [Transcription]" /db_xref="CDD:227479" Site order(6,8..11,14,18..19,21..23,28..30,33,36..37,40..41, 43..46,49..50,53,63..66,69,81,84,88,92) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467030" Site order(9,11..13,61..63,93,99..100) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:467030" Site order(113,116..117,119..120,123..124,127..128) /site_type="other" /note="TBP binding site [polypeptide binding]" /db_xref="CDD:467030" CDS 1..146 /gene="NCB2" /locus_tag="YDR397C" /gene_synonym="YDR1" /coded_by="NM_001180705.1:1..441" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8948634|PMID:9023340|PMID:9096360]" /experiment="EXISTENCE:direct assay:GO:0001046 core promoter sequence-specific DNA binding [PMID:18703679]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18703679]" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:8948634]" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9023340]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21976730]" /experiment="EXISTENCE:direct assay:GO:0017054 negative cofactor 2 complex [PMID:8948634]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8948634]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10713169]" /experiment="EXISTENCE:genetic interaction:GO:0003714 transcription corepressor activity [PMID:10713169]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9023340|PMID:10713169]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:9023340|PMID:10713169]" /experiment="EXISTENCE:mutant phenotype:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:9023340]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:18048413]" /experiment="EXISTENCE:mutant phenotype:GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:21976730]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:18048413]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:18048413]" /experiment="EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:9096360]" /experiment="EXISTENCE:physical interaction:GO:0017054 negative cofactor 2 complex [PMID:9023340]" /note="Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta; complex also includes Bur6p" /db_xref="GeneID:852006" /db_xref="SGD:S000002805" ORIGIN 1 magdsdnvsl pkatvqkmis eildqdlmft kdareiiins giefimilss masemadnea 61 kktiapehvi kaleeleyne fipfleeill nfkgsqkvke trdskfkksg lseeellrqq 121 eelfrqsrsr lhhnsvsdpv ksedss // LOCUS NP_010686 643 aa linear PLN 30-JUN-2025 DEFINITION Utp5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010686 VERSION NP_010686.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180706.1 REFERENCE 1 (residues 1 to 643) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 643) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 643) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 643) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12241. Method: conceptual translation. FEATURES Location/Qualifiers source 1..643 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..643 /product="Utp5p" /calculated_mol_wt="71871" Region 3..256 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 60..102 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 108..143 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 148..185 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 192..231 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 448..548 /region_name="Utp12" /note="Dip2/Utp12 Family; pfam04003" /db_xref="CDD:461125" CDS 1..643 /gene="UTP5" /locus_tag="YDR398W" /coded_by="NM_001180706.1:1..1932" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:15489292]" /experiment="EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]" /note="Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit" /db_xref="GeneID:852007" /db_xref="SGD:S000002806" ORIGIN 1 mdspvlqsay dpsgqylcyv tvaldkqrvg vqptqratss gvdtvwnenf lyledsklkv 61 tclkwvnlas sdtvaiilgm nngeiwlysv lanevtykft tgnsyeikdi dlmgnqlwci 121 dssdafyqfd llqfkllqhf rinncvqlnk ltivpagdsv aqllvashsi slidieekkv 181 vmtfpghvsp vstlqvitne ffisgaegdr flnvydihsg mtkcvlvaes dikelshsgq 241 adsiavtted gsleifvdpl vssstkkrgn kskksskkiq ivskdgrkvp iynafinkdl 301 lnvswlqnat mpyfknlqwr eipneytvei slnwnnknks adrdlhgkdl asatnyvegn 361 arvtsgdnfk hvddaikswe reltsleqeq akppqanell tetfgdkles stvarisgkk 421 tnlkgsnlkt atttgtvtvi lsqalqsndh slletvlnnr dervirdtif rlkpalavil 481 lerlaeriar qthrqgplnv wvkwcliihg gylvsipnlm stlsslhstl krrsdllprl 541 laldarldct inkfktlnye agdihssepv veededdvey neelddagli edgeesygse 601 eeeegdsdne eeqkhtsskq dgrleteqsd geeeagysdv eme // LOCUS NP_010687 221 aa linear PLN 30-JUN-2025 DEFINITION hypoxanthine phosphoribosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010687 VERSION NP_010687.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180707.3 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12242. On Jul 30, 2012 this sequence version replaced NP_010687.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..221 /product="hypoxanthine phosphoribosyltransferase" /EC_number="2.4.2.8" /calculated_mol_wt="25060" Region 1..194 /region_name="Hpt1" /note="Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; COG2236" /db_xref="CDD:441837" CDS 1..221 /gene="HPT1" /locus_tag="YDR399W" /gene_synonym="BRA6" /coded_by="NM_001180707.3:1..666" /experiment="EXISTENCE:direct assay:GO:0004422 hypoxanthine phosphoribosyltransferase activity [PMID:7035445|PMID:371963|PMID:6170313]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032263 GMP salvage [PMID:7035445]" /experiment="EXISTENCE:direct assay:GO:0032264 IMP salvage [PMID:7035445|PMID:3546595]" /experiment="EXISTENCE:genetic interaction:GO:0004422 hypoxanthine phosphoribosyltransferase activity [PMID:9335580]" /experiment="EXISTENCE:genetic interaction:GO:0032263 GMP salvage [PMID:20980241]" /experiment="EXISTENCE:mutant phenotype:GO:0004422 hypoxanthine phosphoribosyltransferase activity [PMID:9335580]" /experiment="EXISTENCE:mutant phenotype:GO:0032263 GMP salvage [PMID:20980241]" /note="Dimeric hypoxanthine-guanine phosphoribosyltransferase; catalyzes the transfer of the phosphoribosyl portion of 5-phosphoribosyl-alpha-1-pyrophosphate to a purine base (either guanine or hypoxanthine) to form pyrophosphate and a purine nucleotide (either guanosine monophosphate or inosine monophosphate); mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome" /db_xref="GeneID:852008" /db_xref="SGD:S000002807" ORIGIN 1 msandkqyis ynnvhqlcqv saeriknfkp dliiaigggg fiparilrtf lkepgvptir 61 ifaiilslye dlnsvgseve evgvkvsrtq widyeqckld lvgknvlivd evddtrttlh 121 yalselekda aeqakakgid tekspemktn fgifvlhdkq kpkkadlpae mlndknryfa 181 aktvpdkwya ypwestdivf htrmaieqgn difipeqehk q // LOCUS NP_010688 340 aa linear PLN 30-JUN-2025 DEFINITION trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010688 VERSION NP_010688.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180708.3 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12243. On Jul 30, 2012 this sequence version replaced NP_010688.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..340 /product="trifunctional uridine nucleosidase/nicotinamide riboside hydrolase/nicotinic acid riboside hydrolase" /EC_number="3.2.2.3" /calculated_mol_wt="37829" Region 7..330 /region_name="nuc_hydro_IU_UC_XIUA" /note="inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; cd02651" /db_xref="CDD:239117" Site order(13,17..18,42,85,130,165,173,175,255) /site_type="active" /db_xref="CDD:239117" Site order(75,141,185,282,284..285,293) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:239117" CDS 1..340 /gene="URH1" /locus_tag="YDR400W" /coded_by="NM_001180708.3:1..1023" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0045437 uridine nucleosidase activity [PMID:19001417]" /experiment="EXISTENCE:direct assay:GO:0046135 pyrimidine nucleoside catabolic process [PMID:11872485|PMID:12111094]" /experiment="EXISTENCE:direct assay:GO:0050263 ribosylpyrimidine nucleosidase activity [PMID:11872485|PMID:12111094]" /experiment="EXISTENCE:direct assay:GO:0070635 nicotinamide riboside hydrolase activity [PMID:19001417]" /experiment="EXISTENCE:direct assay:GO:0070636 nicotinic acid riboside hydrolase activity [PMID:19001417]" /experiment="EXISTENCE:genetic interaction:GO:0019358 nicotinate nucleotide salvage [PMID:17482543]" /experiment="EXISTENCE:genetic interaction:GO:0034355 NAD+ biosynthetic process via the salvage pathway [PMID:19001417]" /experiment="EXISTENCE:mutant phenotype:GO:0006216 cytidine catabolic process [PMID:23670538]" /experiment="EXISTENCE:mutant phenotype:GO:0006218 uridine catabolic process [PMID:23670538]" /experiment="EXISTENCE:mutant phenotype:GO:0008655 pyrimidine-containing compound salvage [PMID:11872485]" /note="Uridine nucleosidase (uridine-cytidine N-ribohydrolase); cleaves N-glycosidic bonds in nucleosides; dual roles in NAD+ biosynthesis and the nucleobase salvage pathway; monomeric structure unique to this class of enzymes" /db_xref="GeneID:852009" /db_xref="SGD:S000002808" ORIGIN 1 mtvskipiwl dcdpghddai aillgcfhpa fnllgistcf gnappentdy narslltamg 61 kaqaipvykg aqrpwkreph yapdihgisg ldgtsllpkp tfeartdkty ieaieeaila 121 nngeisfvst galttlatvf rckpylkksv kyisimgggl hglgncnpnl saefnvwidp 181 daanyifrdp dvkdkcivvp lnlthkaiat ykvnemiyne knnsklrelf lelfqffaht 241 ykdmqgfesg ppihdpvalm pllefygwdp ssavgfrykr mdisciddvf nensgkiiie 301 keypndsdvg tiigldlniq yfwdqifeal nradkmstig // LOCUS NP_010690 489 aa linear PLN 30-JUN-2025 DEFINITION putative cytochrome P450 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010690 VERSION NP_010690.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180710.1 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12244. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..489 /product="putative cytochrome P450" /calculated_mol_wt="55940" Region 65..485 /region_name="CYP56-like" /note="cytochrome P450 family 56-like fungal cytochrome P450s; cd11070" /db_xref="CDD:410693" Site order(127,131,138,182,289..290,293..294,297..298,301,347, 357,359,383,427..429,433..437,440..441) /site_type="other" /note="heme binding site [chemical binding]" /db_xref="CDD:410693" Site order(216..217,289,292..293,297,355..358) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:410693" CDS 1..489 /gene="DIT2" /locus_tag="YDR402C" /gene_synonym="CYP56" /coded_by="NM_001180710.1:1..1470" /experiment="EXISTENCE:direct assay:GO:0003959 NADPH dehydrogenase activity [PMID:29365103]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:29365103]" /experiment="EXISTENCE:direct assay:GO:0030476 ascospore wall assembly [PMID:8183942]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:8183942]" /note="N-formyltyrosine oxidase; sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /db_xref="GeneID:852011" /db_xref="SGD:S000002810" ORIGIN 1 mellkllcli lfltlsyvaf aiivpplnfp kniptipfyv vflpvifpid qtelydlyir 61 esmekygavk fffgsrwnil vsrseylaqi fkdedtfaks gnqkkipysa laaytgdnvi 121 saygavwrny rnavtnglqh fddapifkna kilctliknr llegqtsipm gplsqrmald 181 nisqvalgfd fgalthekna fhehlirikk qifhpffltf pfldvlpips rkkafkdvvs 241 frellvkrvq delvnnykfe qttfaasdli rahnneiidy kqltdnivii lvaghenpql 301 lfnsslylla kysnewqekl rkevngitdp kgladlplln aflfevvrmy pplstiinrc 361 ttktcklgae ivipkgvyvg ynnfgtshdp ktwgttaddf kperwgsdie tirknwrmak 421 nrcavtgfhg grraclgekl altemrisla emlkqfrwsl dpeweekltp agplcplnlk 481 lkfnenime // LOCUS NP_010691 536 aa linear PLN 30-JUN-2025 DEFINITION Dit1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010691 VERSION NP_010691.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180711.1 REFERENCE 1 (residues 1 to 536) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 536) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 536) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 536) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12245. Method: conceptual translation. FEATURES Location/Qualifiers source 1..536 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..536 /product="Dit1p" /calculated_mol_wt="61260" Region 205..511 /region_name="DIT1_PvcA" /note="Pyoverdine/dityrosine biosynthesis protein; pfam05141" /db_xref="CDD:461559" CDS 1..536 /gene="DIT1" /locus_tag="YDR403W" /coded_by="NM_001180711.1:1..1611" /experiment="EXISTENCE:direct assay:GO:0003824 catalytic activity [PMID:8183942]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:32503197]" /experiment="EXISTENCE:direct assay:GO:0030476 ascospore wall assembly [PMID:8183942]" /experiment="EXISTENCE:direct assay:GO:0042764 ascospore-type prospore [PMID:32503197]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:8183942]" /note="Sporulation-specific enzyme required for spore wall maturation; involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure" /db_xref="GeneID:852012" /db_xref="SGD:S000002811" ORIGIN 1 mtftsnlpss seqsisppas sfssstdtlk didiphngad lstyskflal ycrsdkcddf 61 ysleekqnck fgdqwldfin tihnldfses evsgrvseri lpaslankft nnlgvaikis 121 eytrdderqi rgcvttvene nsfnnwfvyh ildqsqlsls ehpivtkevk yhelfadffe 181 knlkntivnd qwnfggrdyf iersryftdr ylriecilpa fpckssneqk vygsvpdkge 241 elalkrlika tqdlvkiypp gmkiwivsdg hvfsdcigvd ddvvstyttk lhelykrvai 301 pgvdaigfcg lndlffsgaa skvfdpkwvs dvevahytgt qicpksdlsr qilmkgcdtd 361 agrlrkqiai eghprlhlyr gfsrfmmedl sllehfqsys rkkfkkiism iafnmikrnd 421 aysnlvelif phhlrisiha htnsgpkfgi kvisneqcsi vssledldep kfedflhipt 481 pwhncvvkve dekekyfltk skvvkealek gmydgvwkdt rfdigegghf vikkis // LOCUS NP_010692 171 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase II subunit RPB7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010692 VERSION NP_010692.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180712.3 REFERENCE 1 (residues 1 to 171) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 171) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 171) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 171) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12246. On Jul 30, 2012 this sequence version replaced NP_010692.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..171 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..171 /product="DNA-directed RNA polymerase II subunit RPB7" /calculated_mol_wt="18927" Region 1..171 /region_name="PTZ00162" /note="DNA-directed RNA polymerase II subunit 7; Provisional" /db_xref="CDD:240298" CDS 1..171 /gene="RPB7" /locus_tag="YDR404C" /coded_by="NM_001180712.3:1..516" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:17875743]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:11087726]" /experiment="EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:11087726]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17056745]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:2186966|PMID:2183013|PMID:1331084]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17056745]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:11087726]" /experiment="EXISTENCE:genetic interaction:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:17875743]" /experiment="EXISTENCE:genetic interaction:GO:0006366 transcription by RNA polymerase II [PMID:10082533]" /experiment="EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:11087726]" /experiment="EXISTENCE:mutant phenotype:GO:0003727 single-stranded RNA binding [PMID:11087726]" /experiment="EXISTENCE:mutant phenotype:GO:0045948 positive regulation of translational initiation [PMID:21074047]" /experiment="EXISTENCE:mutant phenotype:GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [PMID:17875743]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:21074047]" /note="RNA polymerase II subunit B16; forms dissociable heterodimer with Rpb4p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation" /db_xref="GeneID:852013" /db_xref="SGD:S000002812" ORIGIN 1 mffikdlsln itlhpsffgp rmkqylktkl leevegsctg kfgyilcvld ydnidiqrgr 61 ilptdgsaef nvkyravvfk pfkgevvdgt vvscsqhgfe vqvgpmkvfv tkhlmpqdlt 121 fnagsnppsy qssedvitik srirvkiegc isqvssihai gsikedylga i // LOCUS NP_010693 263 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL23m MRP20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010693 VERSION NP_010693.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180713.3 REFERENCE 1 (residues 1 to 263) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 263) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 263) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 263) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12247. On Jul 30, 2012 this sequence version replaced NP_010693.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..263 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..263 /product="mitochondrial 54S ribosomal protein uL23m MRP20" /calculated_mol_wt="30435" Region <104..166 /region_name="Ribosomal_L23" /note="Ribosomal protein L23; pfam00276" /db_xref="CDD:459743" CDS 1..263 /gene="MRP20" /locus_tag="YDR405W" /gene_synonym="uL23m" /coded_by="NM_001180713.3:1..792" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:1544898|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:1544898]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:1544898]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:852014" /db_xref="SGD:S000002813" ORIGIN 1 mprltvgtkn mlyplqktla vgsckpeqvp irslasvves sskildksgs drevdinvse 61 kiykwtkagi eqgkehfkvg gnkvyfpkar iillrpnakh tpyqakfivp ksfnkldlrd 121 ylyhiyglra mnittqllhg kfnrmnlqtt rfrepqikkm tiemeepfiw peeprpdens 181 fwdsttpdnm ekyreerlnc lgsdankpgt afdgvvgpye rvaqpfiprf lkreidnkre 241 rhaaelqrad klialnryie dlh // LOCUS NP_010694 1529 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette multidrug transporter PDR15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010694 VERSION NP_010694.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180714.1 REFERENCE 1 (residues 1 to 1529) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1529) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1529) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1529) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12248. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1529 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1529 /product="ATP-binding cassette multidrug transporter PDR15" /calculated_mol_wt="172126" Region 47..162 /region_name="ABC_trans_N" /note="ABC-transporter N-terminal; pfam14510" /db_xref="CDD:464194" Region 110..1518 /region_name="3a01205" /note="Pleiotropic Drug Resistance (PDR) Family protein; TIGR00956" /db_xref="CDD:273362" CDS 1..1529 /gene="PDR15" /locus_tag="YDR406W" /coded_by="NM_001180714.1:1..4590" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:17881724]" /note="Plasma membrane ATP binding cassette (ABC) transporter; multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element; PDR15 has a paralog, PDR5, that arose from the whole genome duplication" /db_xref="GeneID:852015" /db_xref="SGD:S000002814" ORIGIN 1 mssdirdvee rnsrssssss ssnsaaqsig qhpyrgfdse aaervhelar tltsqsllyt 61 ansnnssssn hnahnadsrs vfstdmegvn pvftnpdtpg ynpkldpnsd qfsstawvqn 121 manictsdpd fykpyslgcv wknlsasgds advsyqstfa nivpklltkg lrllkpskee 181 dtfqilkpmd gclnpgellv vlgrpgsgct tllksissns hgfkiakdsi vsynglsssd 241 irkhyrgevv ynaesdihlp hltvyqtlft varmktpqnr ikgvdreaya nhvtevamat 301 yglshtrdtk vgndlvrgvs ggerkrvsia evaicgarfq cwdnatrgld satalefira 361 lktqadigkt aatvaiyqcs qdaydlfdkv cvlddgyqly fgpakdakky fqdmgyycpp 421 rqttadflts itspteriis kefiekgtrv pqtpkdmaey wlqsesyknl ikdidstlek 481 ntdearniir dahhakqakr appsspyvvn ygmqvkylli rnfwrmkqsa svtlwqvign 541 svmafilgsm fykvmkkndt stfyfrgaam ffailfnafs clleifslye trpitekhrt 601 yslyhpsada fasvlsempp klitavcfni ifyflvdfrr nggvfffyfl inviatftls 661 hlfrcvgslt ktlqeamvpa smlllaismy tgfaipktki lgwsiwiwyi nplaylfesl 721 minefhdrrf pcaqyipagp ayqnitgtqr vcsavgaypg ndyvlgddfl kesydyehkh 781 kwrgfgigma yvvffffvyl ilceynegak qkgemvvflr skikqlkkeg klqekhrpgd 841 iennagsspd sattekkild dssegsdsss dnaglglsks eaifhwrdlc ydvpikggqr 901 rilnnvdgwv kpgtltalmg asgagkttll dclaervtmg vitgnifvdg rlrdesfprs 961 igycqqqdlh lktatvresl rfsaylrqps svsieeknry veevikilem qqysdavvgv 1021 ageglnveqr krltigvela arpkllvfld eptsgldsqt awdtcqlmrk lathgqailc 1081 tihqpsailm qqfdrllflq kggqtvyfgd lgegcktmid yfeskgahkc ppdanpaewm 1141 levvgaapgs hatqdynevw rnsdeykavq eeldwmeknl pgrskeptae ehkpfaasly 1201 yqfkmvtirl fqqywrspdy lwskfiltif nqvfigftff kadrslqglq nqmlsifmyt 1261 vifnpilqqy lpsfvqqrdl yearerpsrt fswlafflsq iiveipwnil agtiayciyy 1321 yavgfyanas aagqlherga lfwlfsiafy vyigsmgllm isfnevaeta ahmgtllftm 1381 alsfcgvmat pkvmprfwif myrvspltym idallalgva nvdvkcsnye mvkftppsgt 1441 tcgdymasyi klagtgylsd psatdicsfc avsttnafla tfsshyyrrw rnygificyi 1501 afdyiaatfl ywlsrvpkkn gkisekpkk // LOCUS NP_010695 1289 aa linear PLN 30-JUN-2025 DEFINITION TRAPPII-specific subunit TRS120 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010695 VERSION NP_010695.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180715.1 REFERENCE 1 (residues 1 to 1289) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1289) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1289) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1289) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12249. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1289 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1289 /product="TRAPPII-specific subunit TRS120" /calculated_mol_wt="147532" Region 9..1253 /region_name="TRAPPC9-Trs120" /note="Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit; pfam08626" /db_xref="CDD:430114" CDS 1..1289 /gene="TRS120" /locus_tag="YDR407C" /coded_by="NM_001180715.1:1..3870" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:16314430]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16314430]" /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]" /experiment="EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17041589]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11239471]" /experiment="EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:16314430]" /note="Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic" /db_xref="GeneID:852016" /db_xref="SGD:S000002815" ORIGIN 1 mnilkhfpsy vgpskirtlv ipighwtrke fnnavqklse fneihlsdvt pidspiftpq 61 gfphgklffd fltidhddal elflydfepf rktfviiglv ndysdpltnl nfmkekyptl 121 ispnlvyass tptkeleqti dtmenvfass pdmqknieti mcdiarnflt alnsyyssyk 181 hvtlrspgai ggnavlkttl irqnsytsss sstpmsavqs svsssskags vttaskrlss 241 femttnslkr saslklattl stsenrsqqk slgrqmkilg nfqllagryv dalnsfvdai 301 ttlykvrdyl wlgsaldgis icflllsylg lsyqipqivs licpveklnf essstgispv 361 dsnskatast tasstprnsi siaamqsprn simslsapal nidveninlp llikcisdkv 421 lyyydlslmh nseyapqvvy cefllktltf mtscykssef skdvldnivk nqhralsdip 481 nspmfprfev yfysnklfel qlkemqveaq ikiystmaev yrllgykrkq lfvlrllmva 541 llatpnkiaw hpdyrtlidt iiellnines eakinvddps qstwlilqkk ilqlcikvsr 601 kindfeyvak fssilitkyt hllnqseqda lfkeyiqpsi tnesitsywd pfilrevvin 661 rildsdptsn eiplesdvss leslenrqkt qdinpqevfn pfkrvqptsf vsnnstkvpi 721 lvflvgdkae ftcrvqnpfk fdftindiql deeisefcei drkavsysgp ynvkaesirs 781 itlpliikkp tykkiyeisc lkisilklpl qkfdiindsr rsnpveeeae yskciygklk 841 ikilpeqpql ellstskmtr nswmmldgtk tdfhitvrnk slscainhik iipmnnieqm 901 lkpdywkkmp pddlyimekq ldwlskscvr iiklptvikp netitfdlel dntavpfnft 961 gfdllieygm satdesciyl kklsipyevt lrrtievpsm diiplnelfs sqvenvdwie 1021 yvmskiraes nlhsrdfill lldfrnswid giklnvqfed ftsneyhvea shtsriivpi 1081 kkidykkynf entpipriyp grqfiqsgln eeqtiemrqk fwcrehiisk lkcnwklttd 1141 qsvtgsvdfn kfiekfdhkm vytiypgrlf ygvqllldep kvkvgeiinl kiiteptstc 1201 rrkqnstvnf ldivifdskt skilprsnrr ilyngsltkp isttkvsein leiipiekgr 1261 yefsvcisks nnqdgiiqfd senvilsvi // LOCUS NP_010696 214 aa linear PLN 30-JUN-2025 DEFINITION phosphoribosylglycinamide formyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010696 VERSION NP_010696.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180716.3 REFERENCE 1 (residues 1 to 214) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 214) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 214) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 214) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12250. On Jul 30, 2012 this sequence version replaced NP_010696.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..214 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..214 /product="phosphoribosylglycinamide formyltransferase" /EC_number="2.1.2.2" /calculated_mol_wt="23409" Region 2..214 /region_name="FMT_core" /note="Formyltransferase, catalytic core domain; cl00395" /db_xref="CDD:444886" Site order(8,13..15,101..108,113,123..126,134,160,162..163, 166..167,197) /site_type="active" /db_xref="CDD:187714" Site order(13..14,102..103,124,126,197) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:187714" Site order(101,104,106..108,113,123,162..163,166..167) /site_type="other" /note="cosubstrate binding site" /db_xref="CDD:187714" Site order(123,125,167) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:187714" CDS 1..214 /gene="ADE8" /locus_tag="YDR408C" /coded_by="NM_001180716.3:1..645" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004644 phosphoribosylglycinamide formyltransferase activity [PMID:4581491]" /experiment="EXISTENCE:mutant phenotype:GO:0004644 phosphoribosylglycinamide formyltransferase activity [PMID:4581491]" /experiment="EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:4581491]" /experiment="EXISTENCE:mutant phenotype:GO:0006189 'de novo' IMP biosynthetic process [PMID:4581491]" /experiment="EXISTENCE:mutant phenotype:GO:0046084 adenine biosynthetic process [PMID:17247984]" /note="Phosphoribosyl-glycinamide transformylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway" /db_xref="GeneID:852017" /db_xref="SGD:S000002816" ORIGIN 1 marivvlisg sgsnlqalid aqkqgqlged ahivsvisss kkaygltraa dnniptkvcs 61 lypytkgiak edkaarakar sqfendlakl vleekpdvii cagwllilgs tflsqlqsvp 121 ilnlhpalpg cfdgtthaie mawrkcqden kpltagcmvh yvieevdkge plvvkkleii 181 pgeetleqye qrvhdaehia iveatykvlq qlhk // LOCUS NP_010697 904 aa linear PLN 30-JUN-2025 DEFINITION SUMO ligase SIZ1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010697 VERSION NP_010697.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180717.3 REFERENCE 1 (residues 1 to 904) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 904) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 904) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 904) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12251. On Jul 30, 2012 this sequence version replaced NP_010697.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..904 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..904 /product="SUMO ligase SIZ1" /calculated_mol_wt="100665" Region 34..68 /region_name="SAP" /note="Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; smart00513" /db_xref="CDD:128789" Region 178..312 /region_name="PINIT" /note="PINIT domain; pfam14324" /db_xref="CDD:464136" Region 354..409 /region_name="SP-RING_ScSiz-like" /note="SP-RING finger found in Saccharomyces cerevisiae E3 SUMO-protein ligase SIZ1, SIZ2, and similar proteins; cd16793" /db_xref="CDD:438447" CDS 1..904 /gene="SIZ1" /locus_tag="YDR409W" /gene_synonym="ULL1" /coded_by="NM_001180717.3:1..2715" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16204216]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:18701921]" /experiment="EXISTENCE:direct assay:GO:0005940 septin ring [PMID:11587849]" /experiment="EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:23443663|PMID:26960795]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:26960795|PMID:11577116]" /experiment="EXISTENCE:direct assay:GO:0031397 negative regulation of protein ubiquitination [PMID:23443663]" /experiment="EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:26960795]" /experiment="EXISTENCE:genetic interaction:GO:1990683 DNA double-strand break attachment to nuclear envelope [PMID:27056668]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16204216]" /experiment="EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:11587849]" /experiment="EXISTENCE:mutant phenotype:GO:0019789 SUMO transferase activity [PMID:11577116|PMID:11587849]" /experiment="EXISTENCE:mutant phenotype:GO:0031397 negative regulation of protein ubiquitination [PMID:23443663]" /note="SUMO E3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to primarily cytoplasmic proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; required for sumoylation of septins and histone H3 variant Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; localizes to the septin ring; acts as an adapter between E2, Ubc9p and substrates; tends to compensate for survival of DNA damage in absence of Nfi1p" /db_xref="GeneID:852018" /db_xref="SGD:S000002817" ORIGIN 1 minledywed etpgpdrept nelrneveet itlmellkvs elkdicrsvs fpvsgrkavl 61 qdlirnflqn alvvgksdpy rvqavkflie rirkneplpv ykdlwnalrk gtplsaitvr 121 smegpptvqq qspsvirqsp tqrrktstts stsrappptn pdassssssf avptihfkes 181 pfykiqrlip elvmnvevtg grgmcsakfk lskadynlls npnskhrlyl fsgminplgs 241 rgnepiqfpf pnelrcnnvq ikdnirgfks kpgtakpadl tphlkpytqq nnveliyaft 301 tkeyklfgyi vemitpeqll ekvlqhpkii kqatllylkk tlredeemgl tttstimslq 361 cpisytrmky psksinckhl qcfdalwflh sqlqiptwqc pvcqidiale nlaisefvdd 421 ilqncqknve qveltsdgkw tailedddds dsdsndgsrs pekgtsvsdh hcssshpsep 481 iiinldsddd epngnnphvt nnhddsnrhs ndnnnnsikn ndshnknnnn nnnnnnnnnd 541 nnnsiennds nsnnkhdhgs rsntpshnht knlmndnddd dddrlmaeit snhlkstntd 601 iltekgssap srtldpksyn ivasetttpv tnrvipeylg nsssyigkql pnilgktpln 661 vtavdnsshl ispdvsvssp tprntasnas ssalstppli rmssldprgs tvpdktirpp 721 insnsytasi sdsfvqpqes svfppreqnm dmsfpstvns rfndprlntt rfpdstlrga 781 tilsnngldq rnnslpttea itrndvgrqn stpvlptlpq nvpirtnsnk sglplinnen 841 svpnppntat iplqksrliv npfiprrpys nvlpqkrqls ntsstspimg twktqdygkk 901 ynsg // LOCUS NP_010698 239 aa linear PLN 30-JUN-2025 DEFINITION protein-S-isoprenylcysteine carboxyl O-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010698 VERSION NP_010698.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180718.1 REFERENCE 1 (residues 1 to 239) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 239) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 239) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 239) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12252. Method: conceptual translation. FEATURES Location/Qualifiers source 1..239 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..239 /product="protein-S-isoprenylcysteine carboxyl O-methyltransferase" /EC_number="2.1.1.100" /calculated_mol_wt="27757" Region 127..219 /region_name="ICMT" /note="Isoprenylcysteine carboxyl methyltransferase (ICMT) family; pfam04140" /db_xref="CDD:427740" CDS 1..239 /gene="STE14" /locus_tag="YDR410C" /coded_by="NM_001180718.1:1..720" /experiment="EXISTENCE:direct assay:GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity [PMID:2050108]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11451995|PMID:9693378]" /experiment="EXISTENCE:mutant phenotype:GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity [PMID:8212897|PMID:11451995]" /experiment="EXISTENCE:mutant phenotype:GO:0005637 nuclear inner membrane [PMID:18923140]" /experiment="EXISTENCE:mutant phenotype:GO:0006481 C-terminal protein methylation [PMID:2173693]" /experiment="EXISTENCE:mutant phenotype:GO:0007323 peptide pheromone maturation [PMID:2050108]" /note="Farnesyl cysteine-carboxyl methyltransferase; mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane" /db_xref="GeneID:852019" /db_xref="SGD:S000002818" ORIGIN 1 mhqdfqedeh eypdirrnpl hevtmtsyil gillgifvgl fpqirfknfn lfiialslfh 61 fleyyitaky nplkvhsesf llnngksyma ahsfailecl vesflfpdlk ifsyslatkl 121 ctvlgcllvi lgqytrtiam htaghsfshi vktkkesdhv lvktgvysws rhpsylgffw 181 waigtqllll nplslvifif vlwkffsdri rveekylief fsaeyieykn kvgvgipfi // LOCUS NP_010699 341 aa linear PLN 30-JUN-2025 DEFINITION Dfm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010699 VERSION NP_010699.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180719.1 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12253. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..341 /product="Dfm1p" /calculated_mol_wt="38000" Region 9..341 /region_name="COG5291" /note="Predicted membrane protein [Function unknown]" /db_xref="CDD:227611" CDS 1..341 /gene="DFM1" /locus_tag="YDR411C" /coded_by="NM_001180719.1:1..1026" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:36689475|PMID:26928762|PMID:15093775|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:36689475]" /experiment="EXISTENCE:genetic interaction:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:17083136]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:36689475|PMID:17083136]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:20579315]" /experiment="EXISTENCE:mutant phenotype:GO:1904152 regulation of retrograde protein transport, ER to cytosol [PMID:29351849]" /note="Endoplasmic reticulum (ER) localized protein; involved in ER-associated protein degradation (ERAD), ER stress, and homeostasis; acts as disaggregase that removes misfolded membrane protein aggregates; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p" /db_xref="GeneID:852020" /db_xref="SGD:S000002819" ORIGIN 1 magprnvrtl hgnggrnndv mgpkefwlni ppitrtlftl aivmtivgrl nlinpwyfiy 61 vwnltfkkvq iwrlltscvm lssrampalm elysiydrss qlerghfgpg lsnrrgpmvt 121 vdyayylcfc ilaittatti iygsyypvvl tsgfiscity twsidnanvq imfyglipvw 181 gkyfpliqlf isfvfnegdf visligfttg ylytcldtht lgpiwgmisr kadptygisp 241 ngkfstpwwf tslyaritga hnetatfnnn fanvpssqre trtfsgrgqr lgtapatlsq 301 tsgtdsgras gsqlrsgpsn lnqfqgrgqr vgqtnspsds q // LOCUS NP_010700 235 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein RRP17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010700 VERSION NP_010700.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180720.3 REFERENCE 1 (residues 1 to 235) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 235) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 235) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12254. On Jul 30, 2012 this sequence version replaced NP_010700.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..235 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..235 /product="rRNA-processing protein RRP17" /calculated_mol_wt="27843" Region 18..161 /region_name="Nop25" /note="Nucleolar protein 12 (25kDa); pfam09805" /db_xref="CDD:430839" CDS 1..235 /gene="RRP17" /locus_tag="YDR412W" /coded_by="NM_001180720.3:1..708" /experiment="EXISTENCE:direct assay:GO:0004534 5'-3' RNA exonuclease activity [PMID:20005841]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:20005841]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:20005841]" /experiment="EXISTENCE:direct assay:GO:1990275 preribosome binding [PMID:20005841]" /experiment="EXISTENCE:mutant phenotype:GO:0000477 generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:20005841]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12837249]" /note="5' exoribonuclease required for 5' end processing of pre-60S rRNA; binds late pre-60S ribosomes, accompanying them from nucleolus to nuclear periphery; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; yeast null mutant is complemented by expression of human homolog NOL12" /db_xref="GeneID:852021" /db_xref="SGD:S000002820" ORIGIN 1 mavhtnrqil trgknyatkq skkfgtdevt fdkdsrldyl tgfhkrklqr qkkaqefike 61 qerlrkieer qkirqerkev meeqlktfke slnleaeied akndktedlq vesdeswhgf 121 dsdkddgdnd nnessvkpil kkgaiteiyd dsttveletl epndnfeyla qlnnvkleka 181 ekvlkqsinr atkyakflgv dekqkkkprv kkfryltkne rrinqrkand nkrrr // LOCUS NP_010702 362 aa linear PLN 30-JUN-2025 DEFINITION Erd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010702 VERSION NP_010702.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180722.4 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12255. On Jul 30, 2012 this sequence version replaced NP_010702.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..362 /product="Erd1p" /calculated_mol_wt="43099" Region 1..362 /region_name="COG5409" /note="EXS domain-containing protein [Signal transduction mechanisms]" /db_xref="CDD:227696" CDS 1..362 /gene="ERD1" /locus_tag="YDR414C" /gene_synonym="LDB2" /coded_by="NM_001180722.4:1..1089" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:2178921]" /experiment="EXISTENCE:mutant phenotype:GO:0000301 retrograde transport, vesicle recycling within Golgi [PMID:34821548]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:34821548]" /experiment="EXISTENCE:mutant phenotype:GO:0006621 protein retention in ER lumen [PMID:2178921]" /note="Predicted membrane protein required for lumenal ER protein retention; Golgi inorganic phosphate (Pi) exporter that balances Pi import associated with NDP-sugar transport into the Golgi; involved in recycling of early glycosyltransferases from late to early Golgi compartments; mutants secrete the endogenous ER protein, BiP (Kar2p)" /db_xref="GeneID:852023" /db_xref="SGD:S000002822" ORIGIN 1 meksesnseg lylqnilnvp ppqrfivlii lalwiwtwil kfflhsnldv sqviltrvph 61 dirpgytlqq lhrtarnfal kitriiipfh fatvflfefm niiegplkni ilivyflpli 121 qcvtifwfll kecqiikyct rrclliessp rslrntyili sdtltsfakp lidftlftsl 181 ifrepfthfd lsvallpvlv rllqclreyr llheatllfn alkyscnlpi lfctwrsrvy 241 egsineerlh hvqrwfmlin ssytlfwdvr mdwsldslts lrsrsksavt lkkkmyhsai 301 lvdfllrfww lwvylsqnlk lvaadsdyif fqgemqyfev irrgiwvvfk ldaeyyikfa 361 sk // LOCUS NP_010703 374 aa linear PLN 30-JUN-2025 DEFINITION putative aminopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010703 VERSION NP_010703.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180723.1 REFERENCE 1 (residues 1 to 374) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 374) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 374) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 374) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12256. Method: conceptual translation. FEATURES Location/Qualifiers source 1..374 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..374 /product="putative aminopeptidase" /calculated_mol_wt="42353" Region 81..369 /region_name="M28_AAP" /note="M28 Zn-peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; cd03879" /db_xref="CDD:349875" Site order(177,196,234..235,262..263,307,309,311,328,332,335, 340) /site_type="active" /db_xref="CDD:349875" CDS 1..374 /locus_tag="YDR415C" /coded_by="NM_001180723.1:1..1125" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Putative aminopeptidase; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway" /db_xref="GeneID:852024" /db_xref="SGD:S000002823" ORIGIN 1 mriqslfvlf nvaiiawsyp yeplrvlqvg enevmevpes eklnlrrrgv kffdvtkhts 61 flpffnkeee ptvptynypp eisnkevvdd siknidkgsm hknlakftsf ytryyksdhg 121 fesaewlaat ianitkdipq dtltiehfdh kewkqysiiv rvtgsttped iiiigshqds 181 inlllpsima apgaddngsg tvtnmealrl ytenflkrgf rpnntvefhf ysaeeggllg 241 sldvftayak qkkhvramlq qdmtgyvsdp edehvgivtd yttpaltdfi kliinsylsi 301 pyrdtqcgya csdhgsatrn gfpgsfvies efkktnkyih stmdtldrls lahmaehtki 361 vlgviielgs wsaw // LOCUS NP_010704 859 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SYF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010704 VERSION NP_010704.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180724.1 REFERENCE 1 (residues 1 to 859) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 859) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 859) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 859) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12257. Method: conceptual translation. FEATURES Location/Qualifiers source 1..859 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..859 /product="mRNA splicing protein SYF1" /calculated_mol_wt="100099" Region 16..>102 /region_name="RNA14" /note="Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]; COG5107" /db_xref="CDD:227438" CDS 1..859 /gene="SYF1" /locus_tag="YDR416W" /gene_synonym="NTC90" /coded_by="NM_001180724.1:1..2580" /experiment="EXISTENCE:curator inference:GO:0000384 first spliceosomal transesterification activity [PMID:11842115|PMID:11105756]" /experiment="EXISTENCE:curator inference:GO:0000386 second spliceosomal transesterification activity [PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:19617314]" /experiment="EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:11842115]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:11842115|PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0071008 U2-type post-mRNA release spliceosomal complex [PMID:11105756]" /note="Member of the NineTeen Complex (NTC); that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; relocalizes to the cytosol in response to hypoxia; homologs in human and C. elegans" /db_xref="GeneID:852025" /db_xref="SGD:S000002824" ORIGIN 1 msayiamkgv itnvdenirn dedvafeyei qktpqniltw kryieywkee grtdkqirwl 61 yerfcsqfvt dtsiwedyir westkevvet srifwlfqrc lkscvrdcdr iclsylelai 121 eqydlamirh alasslmkme remhrkvwdp vikfveekvl pltqldstqe deeestdeae 181 linvllvkgf tkggfiseei sengsrgdiw sshilerylk vapqqkrnes latlaltrdn 241 itiksvyeky lpqdensgky lpsselpfel nfnylaslek lgldnqyeef mrqmngiypd 301 kwlflilsla kyyisrgrld scgdllkksl qqtlrysdfd riynfyllfe qecsqfilgk 361 lkendskffn qkdwteklqa hmatfeslin lydiylndva lrqdsnlvet wmkrvslqks 421 aaekcnvyse ailkidprkv gtpgsfgrlw csygdlywrs naistarelw tqslkvpypy 481 iedleeiyln wadreldkeg verafsiled alhvptnpei llekyknghr kipaqtvlfn 541 slriwskyid yleaycpkda nssdkifnkt kmayntvidl rlitpamaen falflqnhye 601 vmesfqvyek tiplfppeiq yelwieylev atshqlssls pehirflfek alknlcsngi 661 dcktifiays vfeerisgli sksieilrrg avigtvsvst hlesrlqlwr mciskaestl 721 gpsvtrelyq eciqilpnsk avefvikfsd fessigetir areilaygak llppsrntel 781 wdsfeifelk hgdketykdm lkmkkvlesn mlidsasvsh eegninfvaa atshapnsht 841 ltqstssysi npdeieldi // LOCUS NP_010706 165 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL11 RPL12B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010706 VERSION NP_010706.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180726.3 REFERENCE 1 (residues 1 to 165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 165) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12258. On Jul 30, 2012 this sequence version replaced NP_010706.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..165 /product="60S ribosomal protein uL11 RPL12B" /calculated_mol_wt="17692" Region 1..165 /region_name="PLN03072" /note="60S ribosomal protein L12; Provisional" /db_xref="CDD:178621" CDS 1..165 /gene="RPL12B" /locus_tag="YDR418W" /coded_by="NM_001180726.3:1..498" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:genetic interaction:GO:0034517 ribophagy [PMID:39934334]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:9822666]" /note="Ribosomal 60S subunit protein L12B functions as a ribophagy receptor; phosphorylation by Atg1p triggers ribophagy during starvation; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to human RPL12, Drosophila rpl12, and C. elegans ppl-12 that all function as conserved ribophagy receptors; RPL12B has a paralog, RPL12A, that arose from the whole genome duplication" /db_xref="GeneID:852026" /db_xref="SGD:S000002826" ORIGIN 1 mppkfdpnev kylylravgg evgasaalap kigplglspk kvgediakat kefkgikvtv 61 qlkiqnrqaa asvvpsassl vitalkeppr drkkdknvkh sgniqldeii eiarqmrdks 121 fgrtlasvtk eilgtaqsvg crvdfknphd iieginagei eipen // LOCUS NP_010707 632 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed DNA polymerase eta [Saccharomyces cerevisiae S288C]. ACCESSION NP_010707 VERSION NP_010707.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180727.3 REFERENCE 1 (residues 1 to 632) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 632) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 632) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 632) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12259. On Jul 30, 2012 this sequence version replaced NP_010707.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..632 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..632 /product="DNA-directed DNA polymerase eta" /EC_number="2.7.7.7" /calculated_mol_wt="71384" Region 27..505 /region_name="PolY_Pol_eta" /note="DNA Polymerase eta; cd01702" /db_xref="CDD:176456" Site order(30..32,34..35,60..61,64,67,73,155..156,279) /site_type="active" /db_xref="CDD:176456" Site order(55..56,73,153,310..311,393..398,426,454,456) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:176456" CDS 1..632 /gene="RAD30" /locus_tag="YDR419W" /gene_synonym="DBH1" /coded_by="NM_001180727.3:1..1899" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:10601233|PMID:9974380]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23313845]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:23313845]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:10713149]" /experiment="EXISTENCE:direct assay:GO:0070987 error-free translesion synthesis [PMID:10713149|PMID:9974380|PMID:11027270|PMID:10932195]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:23326240]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:23326240]" /experiment="EXISTENCE:mutant phenotype:GO:0042276 error-prone translesion synthesis [PMID:16387871|PMID:12110599]" /experiment="EXISTENCE:physical interaction:GO:0005657 replication fork [PMID:11545742]" /note="DNA polymerase eta (pol eta); involved in translesion synthesis during post-replication repair; catalyzes synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; involved in formation of post-replicative damage-induced genome-wide cohesion; may also have role in protection against mitochondrial mutagenesis; may possibly be involved in meiosis; mutations in human pol eta are responsible for XPV" /db_xref="GeneID:852028" /db_xref="SGD:S000002827" ORIGIN 1 mskftwkeli qlgspskaye sslaciahid mnaffaqveq mrcglskedp vvcvqwnsii 61 avsyaarkyg isrmdtiqea lkkcsnlipi htavfkkged fwqyhdgcgs wvqdpakqis 121 vedhkvslep yrresrkalk ifksacdlve rasidevfld lgricfnmlm fdneyeltgd 181 lklkdalsni reafiggnyd inshlplipe kikslkfegd vfnpegrdli tdwddvilal 241 gsqvckgird sikdilgytt scglsstknv cklasnykkp daqtivkndc lldfldcgkf 301 eitsfwtlgg vlgkelidvl dlphensikh iretwpdnag qlkefldakv kqsdydrsts 361 nidplktadl aeklfklsrg ryglplssrp vvksmmsnkn lrgkscnsiv dciswlevfc 421 aeltsriqdl eqeynkivip rtvsislktk syevyrksgp vaykginfqs hellkvgikf 481 vtdldikgkn ksyypltkls mtitnfdiid lqktvvdmfg nqvhtfkssa gkedeektts 541 skadektpkl ecckyqvtft dqkalqehad yhlalklseg lngaeesskn lsfgekrllf 601 srkrpnsqht atpqkkqvts sknilsfftr kk // LOCUS NP_010708 1802 aa linear PLN 30-JUN-2025 DEFINITION Hkr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010708 VERSION NP_010708.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180728.1 REFERENCE 1 (residues 1 to 1802) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1802) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1802) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1802) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12260. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1802 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1802 /product="Hkr1p" /calculated_mol_wt="188817" Region 452..>776 /region_name="PHA03307" /note="transcriptional regulator ICP4; Provisional" /db_xref="CDD:223039" CDS 1..1802 /gene="HKR1" /locus_tag="YDR420W" /coded_by="NM_001180728.1:1..5409" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8550469]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:17627274]" /experiment="EXISTENCE:genetic interaction:GO:0005034 osmosensor activity [PMID:17627274]" /experiment="EXISTENCE:genetic interaction:GO:0006972 hyperosmotic response [PMID:17627274]" /experiment="EXISTENCE:genetic interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:17627274]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:8550469]" /experiment="EXISTENCE:mutant phenotype:GO:0006075 (1->3)-beta-D-glucan biosynthetic process [PMID:8550469]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:8550469]" /experiment="EXISTENCE:physical interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:17627274]" /note="Mucin family member that functions as an osmosensor in the HOG pathway; large, highly glycosylated protein that functions redundantly with Msb2p in Sho1p-mediated osmostresss induction of the HOG signaling pathway; cytoplasmic domain interacts with Ahk1p a scaffold protein that prevents cross talk with the Kss1p MAPK of the filamentous growth pathway; mutant displays defects in beta-1,3 glucan synthesis and bud site selection" /db_xref="GeneID:852030" /db_xref="SGD:S000002828" ORIGIN 1 mvslkikkil llvsllnaie aysndtiyst synngiestp systsaisst gssnkenait 61 sssetttmag qygesgstti mdeqetgtss qyisvttttq tsdtmssvkk steiatpsss 121 ivptplqsys desqisqtls hnpksvaesd sdttssesss sviistsdss avpreispii 181 ttdsqiskee gtlaqtssis ettriaqmvt rvsqissita astidgfsse stqtdfsntv 241 sfensveeey amsksqlses ysssstvysg gestadktss spitsfsssy sqttstetse 301 ssrvavgvsr pssitqttsi dsfsmsevel styydlsagn ypdqelivdr patsstaets 361 seasqgvsre sntfavssis ttnfivssas dtvvstsstn tvpyssvhst fvhatsssty 421 issslyssps lsasvsshfg vapfpsayis fssvpvavss tytsspsasv vvpsayassp 481 svpvavssty tsspsapaai sstytsspsa pvavsstyts spsapaaiss tytsspsapv 541 avsstytssp sapaaissty tsspsapvav sstytsspsa pvaisstyts spsvpvavss 601 tytsspsapa aisstytssp sapvavssty tsspsapaai sstytsspsv pvavsstyts 661 spsapaaiss tytsspsvpv avsstytssp sapaaissty tsspsapvav sstytsspsa 721 paaisstyts spsapvavss tytsspsapa aisstytssp sapvavssty tsspsalvvl 781 sststsspyd ivyspstfaa issgytpsps asvamsstss sspydivysl sssasrssia 841 tyefspspst slptsstyty fssayafefs serysttsti aptqihstls ritdfllqts 901 maiqsivsqq istsstlnde ihssalsvfn psasnlvets liisstqasi tspknsakis 961 slqsqlssst knpydtankn tetsgrstvv snflytssaa kpdnekfsat pteittisss 1021 shayslsips shnsvtglsh nfvdssksat sfgyssssis siklsketip asksvsntqe 1081 ritsftstlr ansqsekseg rnsvgslqss hissnpslst ntkvdsksls rkvsktmgen 1141 geetgltttk tqyksssets gsysrsftki sigpattavq tqastnsvft apalstyptt 1201 pypspnsyaw lptaiivess etgpttasfn psitgslpna iepavavsep inhtlitigf 1261 taalnyvflv qnplssaqif nflplvlkyp fsntsseldn sigelstfil syrsgssttt 1321 lspksissls vvkkkknqqk knatkstedl hppqvdtssi avkkivpmvd sskayivsva 1381 evyfpteavt ylqqlilden stlysnpqtp lrslaglids giplggltly gsgdggyvps 1441 ltsssvldss kgnsqnidgt ykygalddfi nsftdsasag kyavkiiifl ivltigvllw 1501 lfvaffafrh rnillkrhpr ncigkslnne relestelsr sssgnqvyne kppesenesv 1561 ysavddhyiv tgentvynti hrlhytindd gdllyrdaip ldfdqtngdd gsgidsivrd 1621 cvydknqdat eaflndeesi sgildvdeng dirlydsysd neesnsfhlp devienynkn 1681 hlcetklhgl gtescttddp dtgnqitnef stgsqtclps tayttplhtn siklhtlryt 1741 esslpkpnqt lfsnledlei ediddngsvs dvhieeldal deelykrmsk vikqqnhqtt 1801 ki // LOCUS NP_010709 950 aa linear PLN 30-JUN-2025 DEFINITION Aro80p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010709 VERSION NP_010709.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180729.1 REFERENCE 1 (residues 1 to 950) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 950) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 950) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 950) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12261. Method: conceptual translation. FEATURES Location/Qualifiers source 1..950 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..950 /product="Aro80p" /calculated_mol_wt="108075" Region 19..64 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(20,24,29..32,34,37,53) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(25,28,35,48,51,58) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 238..>412 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..950 /gene="ARO80" /locus_tag="YDR421W" /coded_by="NM_001180729.1:1..2853" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:23651256]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23651256|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0009074 aromatic amino acid family catabolic process [PMID:10207060]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10207060]" /note="Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids" /db_xref="GeneID:852031" /db_xref="SGD:S000002829" ORIGIN 1 msakkrpsgn aafelpkrrr tyqaciscrs rkvkcdlgpv dnphdppcar ckrelkkcif 61 ssnkgtsndl ppnsinaisl pslgkskqei qndstspils dvplsrkgis seksfksegm 121 kwklelssmq naleflaqaa gtvakegake iikeksttpk plkssldatn ksatdeglkr 181 lsksdstntl yentadmlnh tlntnrktsq lmeeigkvrp pptrkiddfd yigpdslltk 241 eeaielieaf fltmhpffpn iplqlhdpke laeypilfca iltvsaryhp fdtlgldnge 301 dgmrhievhd klwvycqkli sqtiwaeast rsigtvlafi iftewnprsi hykwsdyand 361 pelnnvnarg sknistrkde egltgvgair rsdrmswmlt gsavrlaqdm gfiensskvf 421 ivthisetts amnmnqrsll aesfsvlnln lgkiendgne snedylgnek fylneilpde 481 esklrwkrvf ensendhdne knfltdwere flndeyvlyy snkkddtnla qnhippfplr 541 fsfaqrakie iirilsiaye tiyceknkrk lattdqrhnl svlsvfspli egwlsnyrel 601 lvplsdvpfs ladrknkkqi fdnidringe siitdfnycq lyifslalqv dgktsrlnmn 661 eivtsaryve layrsakeil ssakrvsrqg mlkympvrwv iriirsiafi vkcyltltgs 721 elatnpdarn ilklsaisvd etfdiirdta vtlkeatpde lhlcqryaai lmylctemkl 781 rkksylerpp llrdgttple snresslegq dltkkpifsk rigynktett fepserplte 841 einsnsqnsn dtsskgivdp fveqnnditt allnnelfqg pslsdevtdw fgasedigle 901 fvepwtelie qrymqcgdgd nnnfenlynl fvnsnninnd innsrpitrk // LOCUS NP_010710 815 aa linear PLN 30-JUN-2025 DEFINITION Sip1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010710 VERSION NP_010710.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180730.3 REFERENCE 1 (residues 1 to 815) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 815) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 815) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 815) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 815) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 815) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 815) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 815) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 815) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12262. On Jul 30, 2012 this sequence version replaced NP_010710.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..815 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..815 /product="Sip1p" /calculated_mol_wt="90940" Region <504..562 /region_name="AMPK1_CBM" /note="Glycogen recognition site of AMP-activated protein kinase; pfam16561" /db_xref="CDD:465176" Region 687..804 /region_name="AMPKBI" /note="5'-AMP-activated protein kinase beta subunit, interation domain; smart01010" /db_xref="CDD:214973" CDS 1..815 /gene="SIP1" /locus_tag="YDR422C" /coded_by="NM_001180730.3:1..2448" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11331606]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:14966266]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:14966266]" /experiment="EXISTENCE:direct assay:GO:0031588 nucleotide-activated protein kinase complex [PMID:12393914]" /experiment="EXISTENCE:genetic interaction:GO:0004679 AMP-activated protein kinase activity [PMID:10990457]" /experiment="EXISTENCE:genetic interaction:GO:0007165 signal transduction [PMID:10990457]" /experiment="EXISTENCE:genetic interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:9121458]" /experiment="EXISTENCE:mutant phenotype:GO:0004679 AMP-activated protein kinase activity [PMID:12393914]" /experiment="EXISTENCE:physical interaction:GO:0031588 nucleotide-activated protein kinase complex [PMID:9121458|PMID:7813428|PMID:1496382]" /note="One of three alternate beta-subunits of the Snf1p kinase complex; may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions" /db_xref="GeneID:852032" /db_xref="SGD:S000002830" ORIGIN 1 mgnspstqdp shstkkehgh hfhdafnkdr qgsitsqlfn nrksthkrra shtsehngai 61 pprmqllash dpstdcdgrm ssdttidkgp shlfkkdysl ssaadvndtt lanltlsddh 121 dvgapeeqvk spsflspgps matvkrtksd lddlstlnyt mvdettener ndkphherhr 181 ssiialkknl lessatasps ptrsssvhsa slpaltktds idipvrqpys kkpsihayqy 241 qylnndetfs ensqmdkegn sdsvdaeagv lqsedmvlnq sllqnalkkd mqrlsrvnss 301 nsmytaeris hannngnien ntrnkgnagg snddftapis atakmmmkly gdktlmerdl 361 nkhhnktkka qnkkirsvsn srrssfaslh slqsrksilt nglnlqplhp lhpiindnes 421 qysapqhrei shhsnsmssm ssisstnste ntlvvlkwkd dgtvaattev fivstdiasa 481 lkeqreltld enasldsekq lnprirmvyd dvhkewfvpd lflpagiyrl qfsingilth 541 snflptatds egnfvnwfev lpgyhtiepf rneadidsqv eptldeelpk rpelkrfpss 601 srkssyysak gverpstpfs dyrglsrsss inmrdsfvrl kassldlmae vkperlvysn 661 eipnlfnigd gstisvkgds ddvhpqepps fthrvvdcnq ddlfatlqqg gnidaetaea 721 vflsrypvpd lpiylnssyl nrilnqsnqn sesherdega inhiiphvnl nhlltssird 781 eiisvacttr yegkfitqvv yapcyyktqk sqisn // LOCUS NP_010711 409 aa linear PLN 30-JUN-2025 DEFINITION Cad1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010711 VERSION NP_010711.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180731.3 REFERENCE 1 (residues 1 to 409) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 409) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 409) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 409) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12263. On Jul 30, 2012 this sequence version replaced NP_010711.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..409 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..409 /product="Cad1p" /calculated_mol_wt="45621" Region 44..>87 /region_name="bZIP_YAP" /note="Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain; cd14688" /db_xref="CDD:269836" Site order(44..45,49..50,52..54,56..57,60..61,63..64) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269836" Region <355..406 /region_name="PAP1" /note="Transcription factor PAP1; pfam08601" /db_xref="CDD:369990" CDS 1..409 /gene="CAD1" /locus_tag="YDR423C" /gene_synonym="YAP2" /coded_by="NM_001180731.3:1..1230" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9372930]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17187783|PMID:15341652]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15341652|PMID:17187783]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9372930]" /experiment="EXISTENCE:genetic interaction:GO:0033554 cellular response to stress [PMID:9372930]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9372930]" /note="AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication" /db_xref="GeneID:852033" /db_xref="SGD:S000002831" ORIGIN 1 mgnilrkgqq iylagdmkkq mllnkdgtpk rkvgrpgrkr idseaksrrt aqnraaqraf 61 rdrkeakmks lqervelleq kdaqnktttd fllcslksll seitkyrakn sdderilafl 121 ddlqeqqkre nekgtstavs kaakelpspn sdenmtvnts ievqphtqen ekvmwnigsw 181 napsltnswd sppgnrtgav tigdesings empdfsldlv sndrqtglea ldydihnyfp 241 qhserltaek idtsacqcei dqkylpyete ddtlfpsvlp lavgsqcnni cnrkcigtkp 301 csnkeikcdl itshllnqks lasvlpvaas htktirtqse aiehissais ngkascyhil 361 eeisslpkys sldiddlcse liikakctdd ckivvkardl qsalvrqll // LOCUS NP_010712 92 aa linear PLN 30-JUN-2025 DEFINITION dynein light chain [Saccharomyces cerevisiae S288C]. ACCESSION NP_010712 VERSION NP_010712.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180732.1 REFERENCE 1 (residues 1 to 92) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 92) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 92) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 92) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12264. Method: conceptual translation. FEATURES Location/Qualifiers source 1..92 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..92 /product="dynein light chain" /calculated_mol_wt="10310" Region 8..91 /region_name="DLC-like_DYNLL1_DYNLL2" /note="dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family; cd21452" /db_xref="CDD:412000" CDS 1..92 /gene="DYN2" /locus_tag="YDR424C" /gene_synonym="SLC1" /coded_by="NM_001180732.1:1..279" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:21633107]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:22375831]" /experiment="EXISTENCE:genetic interaction:GO:0008574 plus-end-directed microtubule motor activity [PMID:23761070]" /experiment="EXISTENCE:genetic interaction:GO:0051292 nuclear pore complex assembly [PMID:17546040]" /experiment="EXISTENCE:mutant phenotype:GO:0008574 plus-end-directed microtubule motor activity [PMID:21633107|PMID:23761070]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:22213798]" /experiment="EXISTENCE:mutant phenotype:GO:0040001 establishment of mitotic spindle localization [PMID:22213798|PMID:21633107]" /experiment="EXISTENCE:mutant phenotype:GO:0051292 nuclear pore complex assembly [PMID:17546040]" /experiment="EXISTENCE:physical interaction:GO:0005868 cytoplasmic dynein complex [PMID:21633107]" /experiment="EXISTENCE:physical interaction:GO:0051292 nuclear pore complex assembly [PMID:17546040]" /note="Cytoplasmic light chain dynein, microtubule motor protein; required for intracellular transport and cell division; involved in mitotic spindle positioning; forms complex with dynein intermediate chain Pac11p that promotes Dyn1p homodimerization, potentiates motor processivity; Dyn2p-Pac11p complex important for interaction of dynein motor complex with dynactin complex; acts as molecular glue to dimerize, stabilize Nup82-Nsp1-Nup159 complex module of cytoplasmic pore filaments" /db_xref="GeneID:852034" /db_xref="SGD:S000002832" ORIGIN 1 msdenkstpi vkasditdkl kediltiskd aldkyqlerd iagtvkkqld vkygntwhvi 61 vgknfgsyvt hekghfvyfy igplaflvfk ta // LOCUS NP_010713 625 aa linear PLN 30-JUN-2025 DEFINITION Snx41p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010713 VERSION NP_010713.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180733.1 REFERENCE 1 (residues 1 to 625) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 625) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 625) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 625) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12265. Method: conceptual translation. FEATURES Location/Qualifiers source 1..625 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..625 /product="Snx41p" /calculated_mol_wt="70610" Region 87..624 /region_name="COG5391" /note="Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]" /db_xref="CDD:227680" CDS 1..625 /gene="SNX41" /locus_tag="YDR425W" /coded_by="NM_001180733.1:1..1878" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:12554655]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:11557775]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:12554655]" /note="Sorting nexin; involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p" /db_xref="GeneID:852035" /db_xref="SGD:S000002833" ORIGIN 1 mdynifeavh eqqsstsdmd lseednnpfv gthhlyasgi gttigearpe nensppssss 61 lpsspahsss agssrastss stsshavvea daetepfvsl smsttatisk ftphdmngtq 121 qiqiidagdf kdpwgkhaig yvilyennki irrysefhsl rqsltrllpt iiippipskh 181 sllkyiwspi naandskiis trkkmlnsfl snclniqeis ndivfqkfln pefnwkdvls 241 sspiiilpln nllapplspt kpsplhsilp ipsnsslrny nsiwqqhitv kshneisnlp 301 teilqnesqf thienlfqny kriithllkn irsnkshfhs lstyfaelga yynafslend 361 itmpnslres ennsnnpmme iishiektgh sfdviyisse iliekytsil edpinellqf 421 lnesfkvlnf kklkflqfki lerliieket klsslteien qlqkineslt rstiltdeny 481 kdtkaadltf vkkdvrslsk sssnssssgh qneihigask lnyktstptm nlnkleikql 541 teqerskqik qlnqdlsklk dclsicisdm leinnssyns lmhtynhinl tigkilklfa 601 asfkawikec lknwklaklq ideal // LOCUS NP_010715 393 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle lid subunit RPN9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010715 VERSION NP_010715.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180735.3 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12266. On Jul 30, 2012 this sequence version replaced NP_010715.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..393 /product="proteasome regulatory particle lid subunit RPN9" /calculated_mol_wt="45651" Region 249..352 /region_name="PCI" /note="PCI domain; pfam01399" /db_xref="CDD:460195" Region 356..388 /region_name="Rpn9_C" /note="Rpn9 C-terminal helix; pfam18261" /db_xref="CDD:436371" CDS 1..393 /gene="RPN9" /locus_tag="YDR427W" /gene_synonym="NAS7" /coded_by="NM_001180735.3:1..1182" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:11742986|PMID:9741626]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:10490597]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10490597]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:10490597]" /note="Non-ATPase regulatory subunit of the 26S proteasome; similar to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852037" /db_xref="SGD:S000002835" ORIGIN 1 mfnnheidti lstlrmeadp slhplfeqfe kfyeeklwfq lsesltkffd dakstplrlr 61 lydnfvskfy dkinqlsvvk yllaslkdsk dfdeslkyld dlkaqfqeld skkqrnngsk 121 dhgdgillid seiartyllk ndlvkardll ddlektldkk dsiplritns fystnsqyfk 181 fkndfnsfyy tsllylstle pstsitlaer qqlaydlsis allgdkiynf gellhhpime 241 tivndsnydw lfqllnaltv gdfdkfdsli kvqiskipil aqhesflrqk iclmtlietv 301 fvknirmlsf ediskathlp kdnvehlvmr aislgllkgs idqvnelvti swvqpriisg 361 dqitkmkdrl vewndqvekl gkkmeargqs iwv // LOCUS NP_010716 261 aa linear PLN 30-JUN-2025 DEFINITION arylformamidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010716 VERSION NP_010716.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180736.3 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12267. On Jul 30, 2012 this sequence version replaced NP_010716.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..261 /product="arylformamidase" /EC_number="3.5.1.9" /calculated_mol_wt="29860" Region 31..>123 /region_name="Aes" /note="Acetyl esterase/lipase [Lipid transport and metabolism]; COG0657" /db_xref="CDD:440422" CDS 1..261 /gene="BNA7" /locus_tag="YDR428C" /coded_by="NM_001180736.3:1..786" /experiment="EXISTENCE:direct assay:GO:0004061 arylformamidase activity [PMID:18205391]" /experiment="EXISTENCE:direct assay:GO:0009435 NAD+ biosynthetic process [PMID:18205391]" /note="Formylkynurenine formamidase; involved in the de novo biosynthesis of NAD from tryptophan via kynurenine" /db_xref="GeneID:852038" /db_xref="SGD:S000002836" ORIGIN 1 msntvraisp ditlfnktlt fqeisqntre aviyihggaw ndpentpndf nqlantiksm 61 dtestvcqys ieyrlspeit nprnlydavs nitrlvkekg ltninmvghs vgatfiwqil 121 aalkdpqekm seaqlqmlgl lqivkrvfll dgiyslkell veypeydcft rlafpdgiqm 181 yeeepsrvmp yvkkalsrfs idmhlvhsys delltlrqtn clisclqdyq lsfklylddl 241 glhndvykng kvakyifdni c // LOCUS NP_010717 274 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF3 core subunit g [Saccharomyces cerevisiae S288C]. ACCESSION NP_010717 VERSION NP_010717.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180737.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12268. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..274 /product="translation initiation factor eIF3 core subunit g" /calculated_mol_wt="30370" Region 6..127 /region_name="eIF3g" /note="Eukaryotic translation initiation factor 3 subunit G; pfam12353" /db_xref="CDD:463545" Region 192..268 /region_name="RRM_eIF3G_like" /note="RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit G (eIF-3G) and similar proteins; cd12408" /db_xref="CDD:409842" CDS 1..274 /gene="TIF35" /locus_tag="YDR429C" /coded_by="NM_001180737.1:1..825" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9660829|PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:15838098]" /experiment="EXISTENCE:mutant phenotype:GO:0002188 translation reinitiation [PMID:20679478]" /experiment="EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:25925566]" /experiment="EXISTENCE:physical interaction:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9660829]" /note="eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation; eIF3 is also involved in programmed stop codon readthrough" /db_xref="GeneID:852039" /db_xref="SGD:S000002837" ORIGIN 1 msevapeeii enadgsrsii tykiedgvky kitqkvkevk vlekvhksva erknwhkygs 61 ekgspagpsa vtarlgeeve lrlsrnwkqa eeeriqkeka sltktglqcr lcgndhmtmn 121 cpfktilsel saledpatne ggveaaseek agqvggagsi pgqyvppsrr agardpssda 181 yrdsrerddm ctlkimqvne nadenslree llfpfapipr vsvvrnketg ksrglafvtf 241 sseevaeqal rfldgrgymn lilrvewskp kvke // LOCUS NP_010718 989 aa linear PLN 30-JUN-2025 DEFINITION pitrilysin family metalloprotease [Saccharomyces cerevisiae S288C]. ACCESSION NP_010718 VERSION NP_010718.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180738.1 REFERENCE 1 (residues 1 to 989) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 989) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 989) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 989) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 989) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 989) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 989) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 989) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 989) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12269. Method: conceptual translation. FEATURES Location/Qualifiers source 1..989 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..989 /product="pitrilysin family metalloprotease" /calculated_mol_wt="112050" Region 19..972 /region_name="Cym1" /note="Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones]; COG1026" /db_xref="CDD:440649" CDS 1..989 /gene="CYM1" /locus_tag="YDR430C" /gene_synonym="MOP112" /coded_by="NM_001180738.1:1..2970" /experiment="EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:15606766]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15606766|PMID:14562095|PMID:24769239|PMID:14576278|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:15772085]" /experiment="EXISTENCE:genetic interaction:GO:0034982 mitochondrial protein processing [PMID:28228553]" /experiment="EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:15772085]" /experiment="EXISTENCE:mutant phenotype:GO:0051603 proteolysis involved in protein catabolic process [PMID:15772085]" /note="Lysine-specific metalloprotease of the pitrilysin family; metalloprotease of the intermembrane space; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology; mutation in human homolog PITRM1 is implicated in autosomal recessive spinocerebellar ataxias (ARCA)" /db_xref="GeneID:852041" /db_xref="SGD:S000002838" ORIGIN 1 mlrfqrfass yaqaqavrky pvggifhgye vrrilpvpel rltavdlvhs qtgaehlhid 61 rddknnvfsi afktnppdst gvphilehtt lcgsvkypvr dpffkmlnks lanfmnamtg 121 pdytffpfst tnpqdfanlr gvyldstlnp llkqedfdqe gwrlehknit dpesnivfkg 181 vvynemkgqi snanyyfwsk fqqsiypsln nsggdpmkit dlrygdlldf hhknyhpsna 241 ktftygnlpl vdtlkqlneq fsgygkrark dkllmpidlk kdidvkllgq idtmlppekq 301 tkasmtwicg apqdtydtfl lkvlgnllmd ghssvmyqkl iesgiglefs vnsgveptta 361 vnlltvgiqg vsdieifkdt vnnifqnlle tehpfdrkri daiieqlels kkdqkadfgl 421 qllysilpgw tnkidpfesl lfedvlqrfr gdletkgdtl fqdlirkyiv hkpcftfsiq 481 gseefsksld deeqtrlrek italdeqdkk nifkrgillq ekqnekedls clptlqikdi 541 pragdkysie qknntmsrit dtngityvrg krllndiipf elfpylplfa esltnlgttt 601 esfseiedqi klhtggisth vevtsdpntt eprlifgfdg wslnsktdhi fefwskille 661 tdfhknsdkl kvlirllass ntssvadagh afargysaah yrssgainet lngieqlqfi 721 nrlhslldne etfqrevvdk ltelqkyivd tnnmnffits dsdvqaktve sqiskfmerl 781 phgsclpngp ktsdypligs kckhtlikfp fqvhytsqal lgvpythkdg salqvmsnml 841 tfkhlhrevr ekggayggga sysalagifs fysyrdpqpl ksletfknsg ryilndakwg 901 vtdldeaklt ifqqvdapks pkgegvtyfm sgvtddmkqa rreqlldvsl ldvhrvaeky 961 llnkegvstv igpgiegktv spnwevkel // LOCUS NP_010720 414 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding protein NPL3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010720 VERSION NP_010720.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180740.3 REFERENCE 1 (residues 1 to 414) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 414) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 414) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 414) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12270. On Jul 30, 2012 this sequence version replaced NP_010720.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..414 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..414 /product="mRNA-binding protein NPL3" /calculated_mol_wt="45276" Region <11..87 /region_name="PHA03247" /note="large tegument protein UL36; Provisional" /db_xref="CDD:223021" Region 126..192 /region_name="RBD_RRM1_NPL3" /note="RNA recognition motif 1 (RRM1) found in yeast nucleolar protein 3 (Npl3p) and similar proteins; cd12340" /db_xref="CDD:409777" Region 200..271 /region_name="RRM2_SRSF1_4_like" /note="RNA recognition motif 2 (RRM2) found in serine/arginine-rich splicing factor SRSF1, SRSF4 and similar proteins; cd12339" /db_xref="CDD:409776" CDS 1..414 /gene="NPL3" /locus_tag="YDR432W" /gene_synonym="MTR13; MTS1; NAB1; NOP3" /coded_by="NM_001180740.3:1..1245" /experiment="EXISTENCE:direct assay:GO:0003691 double-stranded telomeric DNA binding [PMID:32026548]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:17684230|PMID:23222640|PMID:7774613]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:15572678|PMID:22842922|PMID:7962083]" /experiment="EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:7962083]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0031370 eukaryotic initiation factor 4G binding [PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:18818768]" /experiment="EXISTENCE:direct assay:GO:0061752 telomeric repeat-containing RNA binding [PMID:32026548]" /experiment="EXISTENCE:direct assay:GO:2000805 negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [PMID:15902270]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:19061647]" /experiment="EXISTENCE:genetic interaction:GO:0006415 translational termination [PMID:19733178]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:19061647]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:8675010]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:8675010]" /experiment="EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:19733178]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:18818768]" /experiment="EXISTENCE:mutant phenotype:GO:2000805 negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled [PMID:15902270]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:18818768]" /note="RNA-binding guard protein; promotes transcription elongation and regulates termination; binds eIF4G to repress translation initiation; role in nuclear export of poly(A) mRNA and in pre-mRNA splicing; links chromatin modification to mRNA processing; prevents R-loop-mediated genome instability and replication stress; binds TERRA, stabilizing R-loops at short telomeres; phosphorylated by Sky1p to promote shuttling and mRNA dissociation; protein abundance increases during DNA replication stress" /db_xref="GeneID:852042" /db_xref="SGD:S000002840" ORIGIN 1 mseaqethve qlpesvvdap veeqhqeppq apdapqepqv pqesapqesa pqeppapqeq 61 ndvpppsnap iyegeeshsv qdyqeahqhh qppepqpyyp ppppgehmhg rppmhhrqeg 121 elsntrlfvr pfpldvqese lneifgpfgp mkevkilngf afvefeeaes aakaieevhg 181 ksfanqplev vysklpakry ritmknlpeg cswqdlkdla renslettfs svntrdfdgt 241 galefpseei lvealerlnn iefrgsvitv erddnpppir rsnrggfrgr ggfrggfrgg 301 frggfsrggf ggprggfggp rggyggysrg gyggysrggy ggsrggydsp rggydsprgg 361 ysrggyggpr ndygpprgsy ggsrggydgp rgdygpprda yrtrdaprer sptr // LOCUS NP_010722 534 aa linear PLN 30-JUN-2025 DEFINITION GPI-anchor transamidase GPI17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010722 VERSION NP_010722.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180742.3 REFERENCE 1 (residues 1 to 534) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 534) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 534) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 534) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12271. On Jul 30, 2012 this sequence version replaced NP_010722.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..534 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..534 /product="GPI-anchor transamidase GPI17" /calculated_mol_wt="60683" Region 13..502 /region_name="PIG-S" /note="Phosphatidylinositol-glycan biosynthesis class S protein; pfam10510" /db_xref="CDD:463126" CDS 1..534 /gene="GPI17" /locus_tag="YDR434W" /coded_by="NM_001180742.3:1..1605" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15075373|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15939668]" /experiment="EXISTENCE:direct assay:GO:0042765 GPI-anchor transamidase complex [PMID:15939668]" /experiment="EXISTENCE:mutant phenotype:GO:0016255 attachment of GPI anchor to protein [PMID:11483512]" /note="Transmembrane protein; subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog" /db_xref="GeneID:852044" /db_xref="SGD:S000002842" ORIGIN 1 msnanlrkwv gfcfvaiylf lgvplwyklt tvyraslpin yieslqnnkf qdihlvipvy 61 vksdtyrfpd vhdaiqvqvn hllnsqeqrv pwslqvlpyn etieqmeseg nqfhvvtlkl 121 defigyssay dtketlvyyd daavlsndlp ffvaqtlveh tfqlewthln ktcegvstnn 181 dvaisydpni hlsvtllsgd gnpvaweiep tltdyfspfr kflsplvnft vdssivyhnd 241 lnlhslngsc tsvtwfdlsh tidlselssm ayypedsaln laivfpsass spdglafing 301 trisdeittl dwnsylvpqw gviiinkmpl kpnsvisedy lepmmyrfat difqllglte 361 gsqdllspyi tidsfkrlti lqnldkatet lwslvkltqq fqgmsiprev sdnviealdl 421 rlqiidllnd pgkggdivwn nalhlsnelv klcekaffng emvqqnffpq ehmiavylpl 481 lgpisavmff gfynvmkekn qkskkngter evakeklelk eaqklhaidg edel // LOCUS NP_010723 328 aa linear PLN 30-JUN-2025 DEFINITION leucine carboxy methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010723 VERSION NP_010723.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180743.1 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12272. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..328 /product="leucine carboxy methyltransferase" /EC_number="2.1.1.233" /calculated_mol_wt="37564" Region 5..220 /region_name="LCM" /note="Leucine carboxyl methyltransferase; pfam04072" /db_xref="CDD:427692" CDS 1..328 /gene="PPM1" /locus_tag="YDR435C" /coded_by="NM_001180743.1:1..987" /experiment="EXISTENCE:mutant phenotype:GO:0006481 C-terminal protein methylation [PMID:11060018]" /experiment="EXISTENCE:mutant phenotype:GO:0010506 regulation of autophagy [PMID:23870128]" /experiment="EXISTENCE:mutant phenotype:GO:0018423 protein C-terminal leucine carboxyl O-methyltransferase activity [PMID:11060018]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:11060018]" /note="Carboxyl methyltransferase; methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits; required for methionine to inhibit autophagy and promote growth" /db_xref="GeneID:852045" /db_xref="SGD:S000002843" ORIGIN 1 meriiqqtdy dalscklaai svgylpssgl qrlsvdlskk ytewhrsyli tlkkfsrraf 61 gkvdkamrss fpvmnygtyl rtvgidaail eflvanekvq vvnlgcgsdl rmlpllqmfp 121 hlayvdidyn esvelknsil reseilrisl glskedtaks pflidqgryk laacdlndit 181 ettrlldvct kreiptivis ecllcymhnn esqllintim skfshglwis ydpiggsqpn 241 drfgaimqsn lkesrnlemp tlmtynskek yasrwsaapn vivndmweif naqipeserk 301 rlrslqflde leelkvmqth yilmkaqw // LOCUS NP_010724 710 aa linear PLN 30-JUN-2025 DEFINITION salt homeostasis regulator [Saccharomyces cerevisiae S288C]. ACCESSION NP_010724 VERSION NP_010724.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180744.1 REFERENCE 1 (residues 1 to 710) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 710) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 710) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 710) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 710) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 710) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 710) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 710) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 710) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12273. Method: conceptual translation. FEATURES Location/Qualifiers source 1..710 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..710 /product="salt homeostasis regulator" /EC_number="3.1.3.16" /calculated_mol_wt="78361" Region 397..688 /region_name="MPP_PP1_PPKL" /note="PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain; cd07414" /db_xref="CDD:277359" Site order(454,456,482,486,514..515,519..520,524,563,585..587, 596,610..612,638,662..666) /site_type="active" /db_xref="CDD:277359" Site order(454,456,482,514,563,638) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277359" Site order(486,519..520,524,585..587,596,610..612,662..666) /site_type="other" /note="natural toxin binding site [chemical binding]" /db_xref="CDD:277359" Site order(569,571,588,593,606,615,623..624,626..628,630..632, 647,651,678..679,681,683,685) /site_type="other" /note="MYPT1 binding site [polypeptide binding]" /db_xref="CDD:277359" CDS 1..710 /gene="PPZ2" /locus_tag="YDR436W" /coded_by="NM_001180744.1:1..2133" /experiment="EXISTENCE:mutant phenotype:GO:0006883 intracellular sodium ion homeostasis [PMID:7768897]" /note="Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance" /db_xref="GeneID:852046" /db_xref="SGD:S000002844" ORIGIN 1 mgnsgskqht khnskkddhd gdrkktldlp pltksdtths lkssrslrsl rskrseasla 61 snvqaqtqpl srrsstlgng nrnhrrsnna pitppnnhyl tshpsssrrl ssssrrssmg 121 nnnnselpps miqmepkspi lknstsmhst ssfnsyenal tdddddrgdd ggespsmakv 181 trintsssad rgskrtplrr hnslqpekgv tgfsstsskl rrrsdntlpa syplnaeagg 241 ngsdyfsnrs nshassrkss fgstgntays tplhspalrk mssrdnddsg dnvngrgtsp 301 ipnlnidkps psassaskre ylsayptlah rdsssslspr gkgqrsssss sssqriyvsp 361 psptgdfvhg scadgdngsr tntmvemkrk kpvrpvdide iiqrlldagy aakrtknvcl 421 knseiiqich karelflaqp allelspsvk ivgdvhgqya dllrlftkcg fppmanylfl 481 gdyvdrgkqs letillllcy kikypenffl lrgnhecanv trvygfydec krrcnikiwk 541 tfvdtfntlp laaivtgkif cvhgglspvl nsmdeirhvs rptdvpdfgl indllwsdpt 601 dssnewedne rgvsfcynkv ainkflnkfg fdlvcrahmv vedgyeffnd rslvtvfsap 661 nycgefdnwg avmtvsegll csfelldpld stalkqvmkk grqerklanr // LOCUS NP_010725 140 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol N-acetylglucosaminyltransferase GPI19 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010725 VERSION NP_010725.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180745.3 REFERENCE 1 (residues 1 to 140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 140) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12274. On Jul 30, 2012 this sequence version replaced NP_010725.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..140 /product="phosphatidylinositol N-acetylglucosaminyltransferase GPI19" /EC_number="2.4.1.198" /calculated_mol_wt="15959" Region 3..131 /region_name="PIG-P" /note="pfam08510" /db_xref="CDD:462498" CDS 1..140 /gene="GPI19" /locus_tag="YDR437W" /coded_by="NM_001180745.3:1..423" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:16278447]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:16278447]" /experiment="EXISTENCE:mutant phenotype:GO:0008194 UDP-glycosyltransferase activity [PMID:16278447]" /experiment="EXISTENCE:physical interaction:GO:0000506 glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex [PMID:16278447]" /note="Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis; shares similarity with mammalian PIG-P" /db_xref="GeneID:852047" /db_xref="SGD:S000002845" ORIGIN 1 mytkeyywfs qymiitstlv ltiiwsilps slgeaapkqf intlldifpq rrwiitlesi 61 mlmgmlctyi gllmynedtl tppldslstv tdaggqlvie ddpdvfvkkw afketsgiyd 121 lslmdacqll ylydndhtst // LOCUS NP_010726 370 aa linear PLN 30-JUN-2025 DEFINITION Thi74p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010726 VERSION NP_010726.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180746.3 REFERENCE 1 (residues 1 to 370) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 370) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 370) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 370) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12275. On Jul 30, 2012 this sequence version replaced NP_010726.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..370 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..370 /product="Thi74p" /calculated_mol_wt="41254" Region <140..351 /region_name="RhaT" /note="Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]; COG0697" /db_xref="CDD:440461" CDS 1..370 /gene="THI74" /locus_tag="YDR438W" /coded_by="NM_001180746.3:1..1113" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16850348]" /note="Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication; shows sequence homology to human gene SLC35F3, a thiamine transporter implicated in hypertension" /db_xref="GeneID:852048" /db_xref="SGD:S000002846" ORIGIN 1 mnrvgidvdh migvlllavv vvfwvgascl tnelletnay nkpffltyln issfalyltp 61 dlwriiqsrr kslqertert lpihtqesfs eflpllsstp stssnlssia dtkvkdtmrl 121 sllfcvlwfv anlaanaals yttvasstil sstssfftlf latslgietf stkkllglfv 181 slfgiilivm qsskqqdsvs assflvgntl allgslgysv yttllkyeis skglrldiqm 241 flgyvgiftf llfwpiliil dithmetfel psnfhisflv mlnciiifvs dyfwckalil 301 tsplvvtval tftiplamfa dfvwreafft pwyiigvifi fvsfflvnhr gesavekdca 361 avekgpilda // LOCUS NP_010727 347 aa linear PLN 30-JUN-2025 DEFINITION Lrs4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010727 VERSION NP_010727.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180747.1 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12276. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..347 /product="Lrs4p" /calculated_mol_wt="39223" Region 5..232 /region_name="LRS4" /note="Monopolin complex subunit LRS4; pfam10422" /db_xref="CDD:255978" CDS 1..347 /gene="LRS4" /locus_tag="YDR439W" /coded_by="NM_001180747.1:1..1044" /experiment="EXISTENCE:direct assay:GO:0000183 rDNA heterochromatin formation [PMID:10082585]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10082585]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12689592]" /experiment="EXISTENCE:direct assay:GO:0033551 monopolin complex [PMID:12689592]" /experiment="EXISTENCE:genetic interaction:GO:0051455 spindle attachment to meiosis I kinetochore [PMID:12689592]" /experiment="EXISTENCE:mutant phenotype:GO:0034503 protein localization to nucleolar rDNA repeats [PMID:19362534]" /experiment="EXISTENCE:mutant phenotype:GO:0045143 homologous chromosome segregation [PMID:12689592]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:18923139]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="Nucleolar protein that forms a complex with Csm1p; and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation" /db_xref="GeneID:852049" /db_xref="SGD:S000002847" ORIGIN 1 mttllqllsn yykakldser iyneyvqsqy efasldklnn nkgdpkkvvd etlflqrqia 61 qlnkqlqlsf qenekllsvq knqkalyqsk lsskdafidd lklklkveqi svdkhnkert 121 pstgrdeqqr nskaahtskp tihllspivn rdkpnnqtnd rggndpdspt sqrrsrglrs 181 llssgkntif dsisknldde inenahirnd ttsskiagks psrlsalqks pelrkernnm 241 ilkehilrsk ddqnitssrk ldnielssig dstamtsrss tvnandilgn eendgitklk 301 rvnkltsspv krdcstnkkr kltkqriatl pnsdeelsnn lnvdefv // LOCUS NP_010728 582 aa linear PLN 30-JUN-2025 DEFINITION histone methyltransferase DOT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010728 VERSION NP_010728.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180748.1 REFERENCE 1 (residues 1 to 582) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 582) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 582) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 582) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12277. Method: conceptual translation. FEATURES Location/Qualifiers source 1..582 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..582 /product="histone methyltransferase DOT1" /EC_number="2.1.1.360" /calculated_mol_wt="66070" Region 350..555 /region_name="DOT1" /note="Histone methylation protein DOT1; pfam08123" /db_xref="CDD:149273" CDS 1..582 /gene="DOT1" /locus_tag="YDR440W" /gene_synonym="KMT4; PCH1" /coded_by="NM_001180748.1:1..1749" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11029058]" /experiment="EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:29339748]" /experiment="EXISTENCE:direct assay:GO:0031151 histone H3K79 methyltransferase activity [PMID:12080090|PMID:18158898]" /experiment="EXISTENCE:genetic interaction:GO:0000077 DNA damage checkpoint signaling [PMID:17267293]" /experiment="EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:17267293]" /experiment="EXISTENCE:genetic interaction:GO:0006289 nucleotide-excision repair [PMID:17267293]" /experiment="EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:17267293]" /experiment="EXISTENCE:genetic interaction:GO:0051598 meiotic recombination checkpoint signaling [PMID:11029058]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:17267293]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:17267293]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:17267293]" /experiment="EXISTENCE:mutant phenotype:GO:0031151 histone H3K79 methyltransferase activity [PMID:12080090]" /experiment="EXISTENCE:mutant phenotype:GO:0031452 negative regulation of heterochromatin formation [PMID:26587833]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:26587833|PMID:11029058]" /experiment="EXISTENCE:mutant phenotype:GO:0031571 mitotic G1 DNA damage checkpoint signaling [PMID:16166626]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:16166626]" /experiment="EXISTENCE:mutant phenotype:GO:0070911 global genome nucleotide-excision repair [PMID:21460225]" /note="Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response; single DOT1 gene produces two Dot1p isoforms from alternative translation start sites as a result of leaky scanning by the ribosome" /db_xref="GeneID:852050" /db_xref="SGD:S000002848" ORIGIN 1 mggqesisnn nsdsfimssp nldsqessis pidekkgtdm qtkslssysk gtllskqvqn 61 lleeankydp iygsslprgf lrdrntkgkd nglvplvekv ippihkktnn rntrkksstt 121 tkkdvkkpka akvkgkngrt nhkhtpiskq eidtarekkp lkkgrankkn drdspsstfv 181 dwngpclrlq yplfdieylr sheiysgtpi qsislrtnsp qptsltsdnd tssvttaklq 241 silfsnymee ykvdfkrsta iynpmseigk lieysclvfl pspyaeqlke tilpdlnasf 301 dnsdtkgfvn ainlynkmir eiprqriidh letidkiprs fihdflhivy trsihpqank 361 lkhykafsny vygellpnfl sdvyqqcqlk kgdtfmdlgs gvgncvvqaa lecgcalsfg 421 ceimddasdl tilqyeelkk rcklygmrln nvefslkksf vdnnrvaeli pqcdvilvnn 481 flfdedlnkk vekilqtakv gckiislksl rsltyqinfy nvenifnrlk vqrydlkeds 541 vswthsggey yistvmedvd eslfspaarg rrnrgtpvky tr // LOCUS NP_010729 181 aa linear PLN 30-JUN-2025 DEFINITION adenine phosphoribosyltransferase APT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010729 VERSION NP_010729.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180749.3 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12278. On Jul 30, 2012 this sequence version replaced NP_010729.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..181 /product="adenine phosphoribosyltransferase APT2" /EC_number="2.4.2.7" /calculated_mol_wt="19855" Region 11..180 /region_name="PRTases_typeI" /note="Phosphoribosyl transferase (PRT)-type I domain; cl00309" /db_xref="CDD:444823" Site order(68,70,118..120,134..138,164) /site_type="active" /db_xref="CDD:206754" CDS 1..181 /gene="APT2" /locus_tag="YDR441C" /coded_by="NM_001180749.3:1..546" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Potential adenine phosphoribosyltransferase; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity; APT2 has a paralog, APT1, that arose from the whole genome duplication" /db_xref="GeneID:852051" /db_xref="SGD:S000002849" ORIGIN 1 msisesyake iktafrqftd fpiegeqfed flpiignptl fqklvhtfkt hleekfgkek 61 idfiagiear gllfgpslal algvgfvpir rvgklpgeca sitftkldhe eifemqveai 121 pfdsnvvvvd dvlatggtay aagdlirqvg ahileydfvl vldslhgeek lsapifsilh 181 s // LOCUS NP_010731 1420 aa linear PLN 30-JUN-2025 DEFINITION Ssn2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010731 VERSION NP_010731.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180751.3 REFERENCE 1 (residues 1 to 1420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1420) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12279. On Jul 30, 2012 this sequence version replaced NP_010731.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1420 /product="Ssn2p" /calculated_mol_wt="159871" Region 8..279 /region_name="Med13_N" /note="Mediator complex subunit 13 N-terminal; pfam11597" /db_xref="CDD:463303" Region 1106..1385 /region_name="Med13_C" /note="Mediator complex subunit 13 C-terminal domain; pfam06333" /db_xref="CDD:461879" CDS 1..1420 /gene="SSN2" /locus_tag="YDR443C" /gene_synonym="MED13; NUT8; RYE3; SCA1; SRB9; SSX5; UME2" /coded_by="NM_001180751.3:1..4263" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:15601835]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:11383511|PMID:15477388|PMID:12200444]" /experiment="EXISTENCE:direct assay:GO:0030332 cyclin binding [PMID:29212878]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8524287]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11139488]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15601835]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15601835]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation" /db_xref="GeneID:852053" /db_xref="SGD:S000002851" ORIGIN 1 mssdastyrl edvlssfyrv ekikkinyhq yiskaqndqw siqmefmlrk qdpktlvall 61 srdlwcfsin ddpvptppai ehkpvspdki gtftadyskp nlpphyalfl kalrrkiyin 121 lalgshnkli qfgnacisls gvpnylvqle phlfvngdlt vslcaknmgl vpmkeenlee 181 sflskhalyl apsgirmhla paskqgylit ppkhtelllt tlsvshginl qnkknlkwva 241 vvpdlghlng htptiasylt plleakklvw plhlifaqpv adienstsgd psefhclqda 301 ldaiddfiql kqtaayrtpg ssgvlssnia gtnplssdga yteqfqhykn nsissqpasy 361 hsvqetnkis pkdfspnftg idklmlspsd qfapaflntp nnninenelf ndrkqttvsn 421 dlensplkte leangrslek vnnsvsktgs vdtlhnkegt leqreqnenl psdksdsmvd 481 kelfgedede dlfgdsnksn stnesnksis deitedmfem sdeeennnnk sinknnkemh 541 tdlgkdipff pssekpnirt msgttkrlng krkyldipid emtlptsply mdpgaplpve 601 tprdrrksvf aplnfnpiie nnvdnkyksg gkfsfsplqk eealnfdism adlssseeee 661 deeengssde dlkslnvrdd mkpsdnistn tnihepqyin yssipslqds iikqenfnsv 721 ndanitsnke gfnsiwkipq ndipqtespl ktvdssiqpi esnikmtled nnvtsnpsef 781 tpnmvnseis nlpkdksgip eftpadpnls fesssslpfl lrhmplasip difitptpvv 841 tisekeqdil dliaeqvvtd ynilgnlgip kiayrgvkdc qeglitttml qlfstfdrln 901 gndtiskfyn mkqpyvfvkk hhelikvkhd sqpfikflnf rppngiknfk slllsssfke 961 dclsfaptls qtyinqelgf cellkltned ppglmylkaf dknkllllaa qivsycsnnk 1021 nsiknvppil iilpldnatl telvdkanif qviknevcak mpnielylkv ipmdfirnvl 1081 vtvdqyvnva isiynmlppk svkfthiaht lpekvnfrtm qqqqmqqqqq qqqqqqnnst 1141 gsssiiyyds yihlaysrsv dkewvfaals dsygqgsmtk twyvgnsrgk fddacnqiwn 1201 ialnlaskkf gkicliltrl ngilpddelm nwrrlsgrni hlavvcvddn skisfidedk 1261 lypsfkpiyk dtrfggrmdm trlydyeird idqdihgivf qhpfplahsq hrcairsgal 1321 ikfkkcdgdt vwdkfavnll ncphsdstql letileefrn laalnvwygl sdgedghipw 1381 hilavkkmmn tlvhtrvkia ntsaatvhta tsssiilsdk // LOCUS NP_010732 687 aa linear PLN 30-JUN-2025 DEFINITION putative hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010732 VERSION NP_010732.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180752.1 REFERENCE 1 (residues 1 to 687) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 687) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 687) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 687) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12280. Method: conceptual translation. FEATURES Location/Qualifiers source 1..687 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..687 /product="putative hydrolase" /calculated_mol_wt="77977" Region 192..415 /region_name="DUF676" /note="Putative serine esterase (DUF676); pfam05057" /db_xref="CDD:309968" CDS 1..687 /locus_tag="YDR444W" /coded_by="NM_001180752.1:1..2064" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /note="Putative hydrolase acting on ester bonds" /db_xref="GeneID:852054" /db_xref="SGD:S000002852" ORIGIN 1 mpykinrmkn sleinetggt llvderkrlr igelyrykfs vnkdvikeqg ldvshlflri 61 kneesallrp lyltgpysfy idvrphnyne nrkfpgkeii pfvenlkpde rfkvkillne 121 nsrvgdtsly swtidiisql avttipklef sfrigttrkv vkksnglfks iegvslemwd 181 tetlwdlppk fpekpvhlvi mthgifsnig cdmlymkdki eemtfpmdes inpniivrgf 241 mgnvgksghg ihclgvrvgk yvletvdkln kkykvdrisf ighslggptq smavryisik 301 rpdffdavkg vkpvnfitla spfigvigdf pfylsvpldm galgltgrdl nlkytpltsk 361 dglyaddevy pehskyilei lpqapakkvf esfkrrtiya nvmddgivpl rtaallyldw 421 rsihkvqkir kknknsptss efvssdspes sgasspsnen gnnvgeipae spnkkatlqw 481 tlpqavihgs kinkykrgqt neansdsdne qgvfldgqkf eppkeantvl salsvltaai 541 pdqeyiknpa vrkdevihdk lyhpeelppp hyenrpivkk liypnesvnr iqeriarewq 601 etmtwrkvlv qiqpdshnni vvrrrfvnly gyvavehmve hhfgskvcse laedanepkd 661 epnqssqadr sneynegeis kgaenat // LOCUS NP_010734 302 aa linear PLN 30-JUN-2025 DEFINITION Ecm11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010734 VERSION NP_010734.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180754.1 REFERENCE 1 (residues 1 to 302) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 302) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 302) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 302) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12281. Method: conceptual translation. FEATURES Location/Qualifiers source 1..302 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..302 /product="Ecm11p" /calculated_mol_wt="33982" Region 176..299 /region_name="ECM11" /note="Extracellular mutant protein 11; pfam15463" /db_xref="CDD:434734" CDS 1..302 /gene="ECM11" /locus_tag="YDR446W" /coded_by="NM_001180754.1:1..909" /experiment="EXISTENCE:direct assay:GO:0000795 synaptonemal complex [PMID:23326245|PMID:24098146]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11678331]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:23326245|PMID:15598532]" /experiment="EXISTENCE:mutant phenotype:GO:0070193 synaptonemal complex organization [PMID:23326245]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="Meiosis-specific protein; component of the Synaptonemal Complex (SC) along with Gmc2p; required for efficient crossover formation and for the efficient loading of the SC transverse filament protein, Zip1p; is SUMOlytaed in a Gmc2p manner, and SUMOylation is required for its function in meiosis; GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure" /db_xref="GeneID:852057" /db_xref="SGD:S000002854" ORIGIN 1 mtvikteptt evtlysppsk eslskddahr kkqnnkppss insrsgpnkh klaakapekk 61 inntdkqdls afllnpsliv kpseskkken ivayndtpgi ktehtafqpl tpiskkralk 121 ekaasekcds fdlsrdekpy iqkksktlss vteinsseyk lslngentss pakeksqepi 181 enpgsyqktr nylfekpdpl dtclqdyssm lpsnvaeedq eyfisvadst leewtnkgqe 241 iidqqfqlyq eiikkriels ykfkgiisvi ndradaleeq gqqlegkikk vktlaneiln 301 ii // LOCUS NP_010735 136 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS17 RPS17B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010735 VERSION NP_010735.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180755.3 REFERENCE 1 (residues 1 to 136) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 136) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 136) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 136) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12282. On Jul 30, 2012 this sequence version replaced NP_010735.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..136 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..136 /product="40S ribosomal protein eS17 RPS17B" /calculated_mol_wt="15672" Region 1..115 /region_name="Ribosomal_S17e" /note="Ribosomal S17; pfam00833" /db_xref="CDD:425895" CDS 1..136 /gene="RPS17B" /locus_tag="YDR447C" /gene_synonym="RP51B; RPL51B" /coded_by="NM_001180755.3:1..411" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:3915776]" /note="Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852058" /db_xref="SGD:S000002855" ORIGIN 1 mgrvrtktvk raskaliery ypkltldfqt nkrlcdeiat iqskrlrnki agytthlmkr 61 iqkgpvrgis fklqeeerer kdqyvpevsa ldlsrsngvl nvdnqtsdlv kslglklpls 121 vinvsaqrdr ryrkrn // LOCUS NP_010736 434 aa linear PLN 30-JUN-2025 DEFINITION chromatin-binding transcription regulator ADA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010736 VERSION NP_010736.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180756.3 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12283. On Jul 30, 2012 this sequence version replaced NP_010736.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..434 /product="chromatin-binding transcription regulator ADA2" /calculated_mol_wt="50438" Region 3..434 /region_name="COG5114" /note="Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]" /db_xref="CDD:227445" CDS 1..434 /gene="ADA2" /locus_tag="YDR448W" /gene_synonym="SWI8" /coded_by="NM_001180756.3:1..1305" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9224714|PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0001786 phosphatidylserine binding [PMID:18950642]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:19737915]" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:7972120]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:direct assay:GO:0140671 ADA complex [PMID:10490601|PMID:7862114]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:19737915]" /experiment="EXISTENCE:mutant phenotype:GO:0001786 phosphatidylserine binding [PMID:18950642]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:18950642]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:19737915]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="Transcription coactivator; component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes" /db_xref="GeneID:852059" /db_xref="SGD:S000002856" ORIGIN 1 msnkfhcdvc sadctnrvrv scaicpeydl cvpcfsqgsy tgkhrpyhdy riietnsypi 61 lcpdwgadee lqlikgaqtl glgnwqdiad higsrgkeev kehylkyyle skyypipdit 121 qnihvpqdef leqrrhries frerpleppr kpmasvpsch evqgfmpgrl efetefenea 181 egpvkdmvfe pddqpldiel kfaildiyns rlttraekkr llfenhlmdy rklqaidkkr 241 skeakelynr ikpfarvmta qdfeefskdi leelhcrari qqlqewrsng lttleaglky 301 erdkqariss fekfgastaa slsegnsryr snsahrsnae ysqnysengg rkknmtisdi 361 qhapdyalls ndeqqlciql kilpkpylvl kevmfrellk tggnlsksac rellnidpik 421 anriydffqs qnwm // LOCUS NP_010737 440 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-binding rRNA-processing protein UTP6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010737 VERSION NP_010737.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180757.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12284. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..440 /product="snoRNA-binding rRNA-processing protein UTP6" /calculated_mol_wt="52287" Region 1..440 /region_name="COG5191" /note="Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat [General function prediction only]" /db_xref="CDD:227518" CDS 1..440 /gene="UTP6" /locus_tag="YDR449C" /coded_by="NM_001180757.1:1..1323" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12150911|PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034388 Pwp2p-containing subcomplex of 90S preribosome [PMID:17515605|PMID:15231838]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /note="Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" /db_xref="GeneID:852060" /db_xref="SGD:S000002857" ORIGIN 1 msktryyleq cipemddlve kglftknevs limkkrtdfe hrlnsrgssi ndyikyinye 61 snvnklrakr ckrilqvkkt nslsdwsiqq rigfiyqrgt nkfpqdlkfw amylnymkar 121 gnqtsykkih niynqllklh ptnvdiwisc akyeyevhan fkscrnifqn glrfnpdvpk 181 lwyeyvkfel nfitklinrr kvmglinere qeldmqneqk nnqapdeeks hlqvpstgds 241 mkdklnelpe adisvlgnae tnpalrgdia ltifdvcmkt lgkhyinkhk gyyaisdskm 301 nielnketln ylfseslryi klfdefldle rdylinhvlq fwkndmydls lrkdlpelyl 361 ktvmiditln irympvekld idqlqlsvkk yfayisklds asvkslkney rsylqdnylk 421 kmnaeddpry kildliiskl // LOCUS NP_010738 146 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS13 RPS18A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010738 VERSION NP_010738.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180758.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12285. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..146 /product="40S ribosomal protein uS13 RPS18A" /calculated_mol_wt="16906" Region 1..144 /region_name="PTZ00134" /note="40S ribosomal protein S18; Provisional" /db_xref="CDD:185469" CDS 1..146 /gene="RPS18A" /locus_tag="YDR450W" /coded_by="NM_001180758.1:1..441" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18A has a paralog, RPS18B, that arose from the whole genome duplication; protein increases in abundance and relocalizes from cytoplasm to nuclear foci upon DNA replication stress" /db_xref="GeneID:852061" /db_xref="SGD:S000002858" ORIGIN 1 mslvvqeqgs fqhilrllnt nvdgnikivy alttikgvgr rysnlvckka dvdlhkrage 61 ltqeeleriv qimqnpthyk ipawflnrqn ditdgkdyht lannvesklr ddlerlkkir 121 ahrgirhfwg lrvrgqhtkt tgrrra // LOCUS NP_010739 353 aa linear PLN 30-JUN-2025 DEFINITION Yhp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010739 VERSION NP_010739.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180759.3 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12286. On Jul 30, 2012 this sequence version replaced NP_010739.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..353 /product="Yhp1p" /calculated_mol_wt="39467" Region 123..278 /region_name="COG5576" /note="Homeodomain-containing transcription factor [Transcription]" /db_xref="CDD:227863" CDS 1..353 /gene="YHP1" /locus_tag="YDR451C" /coded_by="NM_001180759.3:1..1062" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:10705372|PMID:12464633]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12464633]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12464633]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10705372]" /experiment="EXISTENCE:mutant phenotype:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:12464633]" /note="Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication" /db_xref="GeneID:852062" /db_xref="SGD:S000002859" ORIGIN 1 mesrntvlps lpniitgtsn spfqlhtlpn tnfpsddqgd irlpplaasa hivrpvvniy 61 kspcdeerpk rkspqavdfl sqrvttsmtp lskpkklssh spftptvrvc skeqppqsmh 121 sykkvniltp lsaakavltp ttrkekkrsf afithsqetf pkkepkidna rlarrkrrrt 181 ssyelgilqt afdecptpnk akrielseqc nmseksvqiw fqnkrqaakk hknsgntshc 241 kvhsndsmsm isysdaalei tstptstkea itaellktsp antssifedh hitpckpggq 301 lkfhrksvlv krtlsntghs eiikspkgke nrlkfnayer kplgevdlns fkn // LOCUS NP_010740 674 aa linear PLN 30-JUN-2025 DEFINITION endopolyphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010740 VERSION NP_010740.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180760.3 REFERENCE 1 (residues 1 to 674) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 674) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 674) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 674) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12287. On Jul 30, 2012 this sequence version replaced NP_010740.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..674 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..674 /product="endopolyphosphatase" /EC_number="3.6.1.10" /EC_number="3.6.1.11" /calculated_mol_wt="78214" Region 97..375 /region_name="MPP_ASMase" /note="acid sphingomyelinase and related proteins, metallophosphatase domain; cd00842" /db_xref="CDD:277321" Site order(102,104,171,224..225,328,362,364) /site_type="active" /note="putative active site [active]" /db_xref="CDD:277321" Site order(102,104,171,224,328,362,364) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:277321" CDS 1..674 /gene="PPN1" /locus_tag="YDR452W" /gene_synonym="PHM5" /coded_by="NM_001180760.3:1..2025" /experiment="EXISTENCE:direct assay:GO:0000298 endopolyphosphatase activity [PMID:11447286|PMID:31175919]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11566881]" /experiment="EXISTENCE:direct assay:GO:0004309 exopolyphosphatase activity [PMID:17009950]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:17009950]" /experiment="EXISTENCE:direct assay:GO:0006797 polyphosphate metabolic process [PMID:11447286]" /experiment="EXISTENCE:direct assay:GO:0006798 polyphosphate catabolic process [PMID:17009950]" /experiment="EXISTENCE:mutant phenotype:GO:0000298 endopolyphosphatase activity [PMID:11447286]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11566881]" /experiment="EXISTENCE:mutant phenotype:GO:0004309 exopolyphosphatase activity [PMID:16862600]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:16862600]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:11447286]" /note="Dual endo- and exopolyphosphatase with a role in phosphate metabolism; acts as both an endopolyphosphatase cleaving long chains of polyphosphate distributively to generate shorter polymer chains and as an exopolyphosphatase catalyzing the hydrolysis of terminal phosphate from polyphosphate; localizes to the vacuole, nucleus and cytosol; functions as a homodimer; relocalizes from vacuole to cytoplasm upon DNA replication stress" /db_xref="GeneID:852063" /db_xref="SGD:S000002860" ORIGIN 1 mvvvgksevr nvsmsrpkkk sliailstcv lfflvfiiga kfqyvsvfsk flddrgdnes 61 lqllndieft rlgltprepv iikdvktgke rklhgrflhi tdihpdpyyv egssidavch 121 tgkpskkkdv apkfgkamsg cdspvilmee tlrwikenlr dkidfviwtg dnirhdndrk 181 hprteaqifd mnnivadkmt elfsagneed prdfdvsvip slgnndvfph nmfalgptlq 241 treyyriwkn fvpqqqqrtf drsasfltev ipgklavlsi ntlylfkanp lvdncnskke 301 pgyqlllwfg yvleelrsrg mkvwlsghvp piaknfdqsc ydkftlwthe yrdiiiggly 361 ghmnidhfip tdgkkarksl lkameqstrv qqgedsneed eetelnrild hamaakevfl 421 mgakpsnkea ymntvrdtyy rkvwnklerv deknvenekk kkekkdkkkk kpitrkelie 481 rysivniggs viptfnpsfr iweynitdiv ndsnfavsey kpwdeffesl nkimedslle 541 demdssniev ginrekmgek knkkkkkndk tmpiempdky elgpayvpql ftptrfvqfy 601 adlekinqel hnsfveskdi fryeieytsd ekpysmdslt vgsyldlagr lyenkpawek 661 yvewsfassg ykdd // LOCUS NP_010741 196 aa linear PLN 30-JUN-2025 DEFINITION thioredoxin peroxidase TSA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010741 VERSION NP_010741.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180761.1 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12288. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..196 /product="thioredoxin peroxidase TSA2" /EC_number="1.11.1.24" /calculated_mol_wt="21484" Region 5..176 /region_name="PRX_Typ2cys" /note="Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; cd03015" /db_xref="CDD:239313" Site order(5,46..47,50,113,123,136..138,140..142,146..147,154, 169..172) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:239313" Site order(44,78..79,104,106,118) /site_type="other" /note="decamer (pentamer of dimers) interface [polypeptide binding]" /db_xref="CDD:239313" Site order(45,48,124) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:239313" Site order(48,169) /site_type="active" /note="peroxidatic and resolving cysteines [active]" /db_xref="CDD:239313" CDS 1..196 /gene="TSA2" /locus_tag="YDR453C" /coded_by="NM_001180761.1:1..591" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10681558]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:15163410]" /experiment="EXISTENCE:direct assay:GO:0008379 thioredoxin peroxidase activity [PMID:10681558]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:15163410]" /experiment="EXISTENCE:direct assay:GO:0045454 cell redox homeostasis [PMID:10681558]" /experiment="EXISTENCE:direct assay:GO:0051920 peroxiredoxin activity [PMID:9888818|PMID:17210445]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:15051715]" /experiment="EXISTENCE:mutant phenotype:GO:0008379 thioredoxin peroxidase activity [PMID:10681558]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:9888818]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:10681558]" /note="Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants; protein abundance increases in response to DNA replication stress; TSA2 has a paralog, TSA1, that arose from the whole genome duplication" /db_xref="GeneID:852064" /db_xref="SGD:S000002861" ORIGIN 1 mvaevqkqap pfkktavvdg ifeeisleky kgkyvvlafv plafsfvcpt eivafsdaak 61 kfedqgaqvl fastdseysl lawtnlprkd gglgpvkvpl ladknhslsr dygvliekeg 121 ialrglfiid pkgiirhiti ndlsvgrnvn ealrlvegfq wtdkngtvlp cnwtpgaati 181 kpdvkdskey fknann // LOCUS NP_010742 187 aa linear PLN 30-JUN-2025 DEFINITION guanylate kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010742 VERSION NP_010742.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180762.1 REFERENCE 1 (residues 1 to 187) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 187) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 187) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 187) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12289. Method: conceptual translation. FEATURES Location/Qualifiers source 1..187 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..187 /product="guanylate kinase" /EC_number="2.7.4.8" /calculated_mol_wt="20506" Region 3..185 /region_name="guanyl_kin" /note="guanylate kinase; TIGR03263" /db_xref="CDD:213788" Site order(9,15,32,39,42,51,74,79) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:238026" Site order(9,15) /site_type="other" /note="G-X2-G-X-G-K" /db_xref="CDD:238026" CDS 1..187 /gene="GUK1" /locus_tag="YDR454C" /gene_synonym="BRA3; PUR5" /coded_by="NM_001180762.1:1..564" /experiment="EXISTENCE:direct assay:GO:0004385 GMP kinase activity [PMID:1334480]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004385 GMP kinase activity [PMID:1334480|PMID:11063676]" /experiment="EXISTENCE:mutant phenotype:GO:0046711 GDP biosynthetic process [PMID:1334480|PMID:11063676]" /note="Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins" /db_xref="GeneID:852065" /db_xref="SGD:S000002862" ORIGIN 1 msrpivisgp sgtgkstllk klfaeypdsf gfsvssttrt pragevngkd ynfvsvdefk 61 smiknnefie waqfsgnyyg stvasvkqvs ksgktcildi dmqgvksvka ipelnarflf 121 iappsvedlk krlegrgtet eesinkrlsa aqaelayaet gahdkvivnd dldkaykelk 181 dfifaek // LOCUS NP_010744 633 aa linear PLN 30-JUN-2025 DEFINITION bifunctional K:H/Na:H antiporter NHX1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010744 VERSION NP_010744.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180764.3 REFERENCE 1 (residues 1 to 633) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 633) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 633) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 633) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12290. On Jul 30, 2012 this sequence version replaced NP_010744.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..633 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..633 /product="bifunctional K:H/Na:H antiporter NHX1" /calculated_mol_wt="70017" Region 55..611 /region_name="Na_H_Exchanger" /note="Sodium/hydrogen exchanger family; cl01133" /db_xref="CDD:470090" CDS 1..633 /gene="NHX1" /locus_tag="YDR456W" /gene_synonym="NHA2; VPL27; VPS44" /coded_by="NM_001180764.3:1..1902" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20826459]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:22210050]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:9694857|PMID:20709757|PMID:22210050]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:22210050]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:10589731]" /experiment="EXISTENCE:mutant phenotype:GO:0015385 sodium:proton antiporter activity [PMID:15635088|PMID:10998367]" /experiment="EXISTENCE:mutant phenotype:GO:0015386 potassium:proton antiporter activity [PMID:15635088]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:10589731]" /experiment="EXISTENCE:mutant phenotype:GO:0035725 sodium ion transmembrane transport [PMID:10998367|PMID:15635088]" /experiment="EXISTENCE:mutant phenotype:GO:0071805 potassium ion transmembrane transport [PMID:15635088]" /note="Na+/H+ and K+/H+ exchanger; required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion; ortholog of human NHE9, which is linked to autism" /db_xref="GeneID:852066" /db_xref="SGD:S000002864" ORIGIN 1 mlskvllnia fkvllttakr avdpddddel lpspdlpgsd dpiagdpdvd lnpvteemfs 61 swalfimlll lisalwssyy ltqkriravh etvlsifygm vigliirmsp ghyiqdtvtf 121 nssyffnvll ppiilnsgye lnqvnffnnm lsilifaipg tfisavvigi ilyiwtflgl 181 esidisfada msvgatlsat dpvtilsifn aykvdpklyt iifgesllnd aisivmfetc 241 qkfhgqpatf ssvfegaglf lmtfsvslli gvligilval llkhthirry pqiesclill 301 iayesyffsn gchmsgivsl lfcgitlkhy ayynmsrrsq itikyifqll arlsenfifi 361 ylglelftev elvykpllii vaaisicvar wcavfplsqf vnwiyrvkti rsmsgitgen 421 isvpdeipyn yqmmtfwagl rgavgvalal giqgeykftl latvlvvvvl tviifggtta 481 gmlevlnikt gciseedtsd defdieapra inllngssiq tdlgpysdnn spdisidqfa 541 vssnknlpnn isttggntfg glnetentsp nparssmdkr nlrdklgtif nsdsqwfqnf 601 deqvlkpvfl dnvspslqds atqspadfss qnh // LOCUS NP_010745 3268 aa linear PLN 30-JUN-2025 DEFINITION E3 ubiquitin-protein ligase TOM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010745 VERSION NP_010745.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180765.3 REFERENCE 1 (residues 1 to 3268) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 3268) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 3268) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 3268) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 3268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 3268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 3268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 3268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 3268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12291. On Jul 30, 2012 this sequence version replaced NP_010745.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..3268 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..3268 /product="E3 ubiquitin-protein ligase TOM1" /EC_number="2.3.2.26" /calculated_mol_wt="374055" Region 92..387 /region_name="DUF908" /note="Domain of Unknown Function (DUF908); pfam06012" /db_xref="CDD:428721" Region 448..>683 /region_name="DUF913" /note="Domain of Unknown Function (DUF913); pfam06025" /db_xref="CDD:461803" Region <1865..2104 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" Region 2327..2359 /region_name="UBM" /note="Ubiquitin binding region; pfam14377" /db_xref="CDD:464159" Region 2367..2399 /region_name="UBM" /note="Ubiquitin binding region; pfam14377" /db_xref="CDD:464159" Region 2385..3268 /region_name="HUL4" /note="Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; COG5021" /db_xref="CDD:227354" CDS 1..3268 /gene="TOM1" /locus_tag="YDR457W" /coded_by="NM_001180765.3:1..9807" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:19578373]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:19578373]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:10395901]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11238398]" /experiment="EXISTENCE:mutant phenotype:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11238398]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11238398]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11238398]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:23129771]" /experiment="EXISTENCE:mutant phenotype:GO:0006913 nucleocytoplasmic transport [PMID:10395901]" /experiment="EXISTENCE:mutant phenotype:GO:0006997 nucleus organization [PMID:10395901]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /note="E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase" /db_xref="GeneID:852068" /db_xref="SGD:S000002865" ORIGIN 1 mvlftrceka rkeklaagyk plvdylidcd tptfleriea iqewdrsrdd lyvwipildr 61 mdglllkvae kykykqdpkk ecevklveme ahdvdyclkm lkftrrllln tenrfvyssg 121 dvlmyllncp nftiklavmr ilailgerfv iarekivahn ifgdhnlrkk tlklalslss 181 svmdedgehf slvdlyfdkk kvpqkwrklr fthytsndfk kssqqknnin etqtsikkvt 241 mttqelcehs lqqifdkgma llpaeswfdf sikasvakaf sddsgenidl rniiietkln 301 aiafvntifs ppqvssklfe ldpyafnslt dlislsetki pkelrtdalf tlecislkhv 361 wcsdiirnlg gnishgllfq ilryiaktlr eatdeideey nvrffylisn ladvkplhes 421 lfaagliptl leivsirncp ykrtlasath lletfidnse tttefiendg ftmlitsvan 481 eidftlahpe twqppkysvv yysisfrela yirsllklvl kllstdsgdr irnlidspil 541 vslkkilenk lvfgltlity tldvvqkvin septiypvlv eaglipyvid nfpkligpsa 601 ellsllpdvv saiclnpegl kqvkekglin nlfdflldad hariltggdr steygtdide 661 larhypdlka nivealcnvi rkmpstfrne reflftspkd qkyffhrkne eiltdkeehe 721 paywelldkg tmldtftsvl fgmslgngsf sqvpqhlear dflaiifmen ppyeyftsva 781 isnvtevlqy ldekyedyaf mdvmkvlndq lenlndflns pndrsffler dgensvrsch 841 sklcrlaail nivtnvyidl ttlsckrimq iysyfdkrgf sliknlkllf qkcaleemyi 901 rqhmpdsvit etmplpivdv sgdgpplqiy iddpkkgdqk gkitsvktrn tlqmrtilyt 961 lqsntailfr cflrlshsrn mdlehkdltt evhifenvve nviemlkate leghlpyilv 1021 llnfntfvft ipkaspnste ilqtipayif yqkggyllyl hiirdlftrm tkikdlssld 1081 ninyidesng iltlsclina ltfynksmqt etmenvqsig kyyvsidddy nimkaltvpi 1141 kvmalamild ldksdslfkt qsrnvpysvf kqllsmlkni ftnvniytke lyelhwdlif 1201 ppikkislfe qvgipgdvaa nyltdtgddl padnsiglfs peqwekykkl igedksiyyp 1261 qpmqaqyykg csskeldelr dtffndglps riftvlpfyp klvnafaktl lqiftkydep 1321 tevfagrild riletdlddp atlsslihlf giflnekyiy qkashlmqrf ieylekslkp 1381 ehvntpwfsk alyvyeiila kselphleel skdvllrypl lsmakvfrip dpmkqklfdi 1441 lirvsdisnf ysalatsril ifysrdelya nniarsgils rllkvigsfq kldkinfles 1501 sfllltrrcf ettenvdali raeinrsfta rplgggddav relttileek ahvvmrspsq 1561 fidvlcetar fhefddqgal vdyslkrflg ekdkntqass teksdiyert gimhlllsql 1621 maasekdwls epanssdlpe nkkaqldpsr npvcaymifl lkllvelvss ynqckfeflt 1681 fsrrntyaer prprttainf flyrlldkpv gtdhdkheak rrevigmlar sviigflatv 1741 qddrttktdv kladphmnfi rkfaieaiik airnatsssk llesnhlkld mwfriitsmv 1801 yvqapylrql ldsnkveadq yqlcklvidl glpsviteam asidlnypfs kkifnvavea 1861 lntisstrnn fsehfkiedh devedevdes dkeeipdmfk nsalgmydve dieedddddt 1921 sligdddama fvdsdngfev vfsdedddmg eedaddarsd seenelssem qsstadgtdv 1981 dyevddadgl iinidqpsgd deemadydan ishsshsene ddasmdviev yddelssgyd 2041 vdlsdydvde sdwdsglssl sisdedsess edepinstrm gdsrrrwlia egveltddsq 2101 geseeddrgv frgiehifsn eneplfrvhd emrhrnhhrs inrthfhsam sapslsllnr 2161 grrnqsnlin plgptgleqv endisdqvtv agsgsrprsh hlhfsevlvs gsffdepvld 2221 giilkstvsr wkdifdmfyd sktyanciip tvinrlykvs lalqkdlenk reqeklknkn 2281 llfneakves hnssdaisve qddiqesnvt hddhepvyvt iqgsevdigg tdidpefmna 2341 lpddiradvf aqhvrerrae arlnsdhnvh sreidsdfle aipediregi ldteaeeqrm 2401 fgrigssadv iradddvsnn deevengldh gnsndrnnad pekkkpariy faplidragi 2461 aslmksvfis kpyiqreiyh elfyrlcssk qnrndlmntf lfilsegiid qhslekvyni 2521 issramghak tttvrqlpsd ctpltvanqt ieilqslida dsrlkyflia ehdnlivnka 2581 nnksrkealp dkklrwplwh lfslldrkli tdesvlmdll trilqvctkt lavlstssng 2641 kenlskkfhl psfdeddlmk ilsiimldsc ttrvfqqtln iiynlsklqg cmsiftkhlv 2701 slaisimskl ksaldglsre vgtittgmei nsellqkftl pssdqakllk ilttvdflyt 2761 hkrkeeernv kdlqslydkm nggpvwssls eclsqfeksq aintsatill plieslmvvc 2821 rrsdlsqnrn tavkyedakl ldfsktrven lffpftdahk kllnqmirsn pklmsgpfal 2881 lvknpkvldf dnkryffnak lksdnqerpk lpitvrreqv fldsyralff ktndeiknsk 2941 leitfkgesg vdaggvtrew yqvlsrqmfn pdyalflpvp sdkttfhpnr tsginpehls 3001 ffkfigmiig kairdqcfld chfsrevykn ilgrpvslkd mesldpdyyk slvwilendi 3061 tdiieetfsv etddygehkv inlieggkdi ivteankqdy vkkvveyklq tsvkeqmdnf 3121 lvgfyalisk dlitifdeqe lellisglpd idvddwknnt tyvnytatck evsyfwravr 3181 sfdaeerakl lqfvtgtskv plngfkelsg vngvckfsih rdfgsserlp sshtcfnqln 3241 lppyesyetl rgslllaine ghegfgla // LOCUS NP_010746 663 aa linear PLN 30-JUN-2025 DEFINITION Heh2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010746 VERSION NP_010746.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180766.1 REFERENCE 1 (residues 1 to 663) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 663) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 663) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 663) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12292. Method: conceptual translation. FEATURES Location/Qualifiers source 1..663 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..663 /product="Heh2p" /calculated_mol_wt="76246" Region 8..42 /region_name="LEM_like" /note="LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; cd12935" /db_xref="CDD:240596" Region 330..661 /region_name="MSC" /note="Man1-Src1p-C-terminal domain; pfam09402" /db_xref="CDD:430586" CDS 1..663 /gene="HEH2" /locus_tag="YDR458C" /coded_by="NM_001180766.1:1..1992" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:16929305]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /note="Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle; HEH2 has a paralog, SRC1, that arose from the whole genome duplication" /db_xref="GeneID:852069" /db_xref="SGD:S000002866" ORIGIN 1 mdhrnldpkt lkvsqlrrvl vendvafpan arkpvlvklf eekvrqrlqs speaskvrts 61 iqkvvksgak nadrkktlks kklesssses ktvkdenvet nkrkreqist dneakmqiqe 121 ekspkkkrkk rsskankppe sppqsksdgk atsadltsel etveelhkkd ssddkprvke 181 lpkpelpnlk vsneflaqln kelasaaten ydhsikstdl ssirieteep vgpstgaetr 241 nesevmenin levqpevkea keeltkiset fdnqdeedts rlsskknirs pkgrtrhfia 301 nktkrgidim kpfiahlfiw lwngaiflsi icpilfglwy reqriqvgyc ghekplksla 361 isafpqterv dsvlqayrpn clecpehgic ssfmnvecep gyepkssile tygiipfpky 421 cakdeskeke vdelvwkvne ylkkknaqhe cgegenlfes getetklydi fshsrpswes 481 qrefndhwkn vleilkkkdd iiwlpldfet ngkreksksn ntnyiyrsts kkwvtlqchl 541 egdiqeyitk yggslfitlg vlflikkiqs tldnyvqgeq iieklvkeai dklkdvkknk 601 geepflttvq lratllsdip nikeqnnlwa qtkekimkeq senielylle engeimtcwe 661 wke // LOCUS NP_010747 374 aa linear PLN 30-JUN-2025 DEFINITION palmitoyltransferase PFA5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010747 VERSION NP_010747.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180767.1 REFERENCE 1 (residues 1 to 374) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 374) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 374) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 374) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12293. Method: conceptual translation. FEATURES Location/Qualifiers source 1..374 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..374 /product="palmitoyltransferase PFA5" /EC_number="2.3.1.225" /calculated_mol_wt="42792" Region 9..335 /region_name="COG5273" /note="Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]" /db_xref="CDD:227598" CDS 1..374 /gene="PFA5" /locus_tag="YDR459C" /coded_by="NM_001180767.1:1..1125" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16647879]" /experiment="EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:16186255]" /experiment="EXISTENCE:direct assay:GO:0018345 protein palmitoylation [PMID:16186255]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain" /db_xref="GeneID:852070" /db_xref="SGD:S000002867" ORIGIN 1 malswnirir rrswfrfilp iivlgllcyg twaychklcy eqvdkrlrqk svsvglicav 61 cfldvvvifi wlqivilvgp gtqphvapfl ilpiaseekt sntsqntsve ydavvppkcy 121 qsdphgypiw csecqslkme rthhsselgh ciprfdhycm wigtvigrdn yrlfvqfaay 181 fstlllimwv sicvyiriit qhnhnyspnl naniistlvf ailgwlltas llassifyms 241 qnktsleaii dskrkkfgtr kifcyysean klrfvvefdr sefhsfwdkk silanikdfm 301 gsnilmwiip lgkpytsrck sdgksgsktt lveilgpyee tlsdytiqai edkisrgeyl 361 atlrasgdds dpay // LOCUS NP_010748 321 aa linear PLN 30-JUN-2025 DEFINITION TFIIH/NER complex subunit TFB3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010748 VERSION NP_010748.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180768.3 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12294. On Jul 30, 2012 this sequence version replaced NP_010748.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..321 /product="TFIIH/NER complex subunit TFB3" /calculated_mol_wt="37997" Region 2..321 /region_name="TFB3" /note="Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3 [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]; COG5220" /db_xref="CDD:227545" CDS 1..321 /gene="TFB3" /locus_tag="YDR460W" /gene_synonym="RIG2" /coded_by="NM_001180768.3:1..966" /experiment="EXISTENCE:curator inference:GO:0000993 RNA polymerase II complex binding [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:27381459|PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0070985 transcription factor TFIIK complex [PMID:19818408]" /experiment="EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:39287137]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:10681587]" /note="Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair; RING domain hydrophobic loop is required for transcription start site scanning as part of TFIIK, the protein kinase component of TFIIH, at the interface with RNAPII in the pre-initiation complex; RING finger protein similar to mammalian CAK and TFIIH subunit" /db_xref="GeneID:852071" /db_xref="SGD:S000002868" ORIGIN 1 mlmdeyeenk dmcpicktdr ylspdvkflv npecyhrice scvdrifslg paqcpykgcd 61 kilrknkfkt qifddvevek evdirkrvfn vfnktiddfn gdlveynkyl eevediiykl 121 dhgidvakte eklrtyeeln kqlimnnler srteiesfeq rqkfekemkl kkrllerqie 181 eeermnkewt kkeivnrlst ttqdinetie gvkntvklkk ssarrkleel nrvlknnpyf 241 nsnvnvqnsr lkdavpftpf ngdreahprf tlkgsvyndp fikdlehrke fiasgfntny 301 ayervlteaf mglgcvisee l // LOCUS NP_010749 36 aa linear PLN 30-JUN-2025 DEFINITION mating pheromone a [Saccharomyces cerevisiae S288C]. ACCESSION NP_010749 VERSION NP_010749.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180769.3 REFERENCE 1 (residues 1 to 36) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 36) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 36) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 36) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12295. On Jul 30, 2012 this sequence version replaced NP_010749.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..36 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..36 /product="mating pheromone a" /calculated_mol_wt="3795" Region 1..36 /region_name="MFA1_2" /note="Mating hormone A-factor 1_2; pfam17317" /db_xref="CDD:407425" CDS 1..36 /gene="MFA1" /locus_tag="YDR461W" /coded_by="NM_001180769.3:1..111" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:10022942]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3285180]" /experiment="EXISTENCE:mutant phenotype:GO:0000772 mating pheromone activity [PMID:3285180]" /note="Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2" /db_xref="GeneID:852072" /db_xref="SGD:S000002869" ORIGIN 1 mqpstataap kektssekkd nyiikgvfwd pacvia // LOCUS NP_001032577 80 aa linear PLN 30-JUN-2025 DEFINITION Cmi8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032577 VERSION NP_001032577.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184679.1 REFERENCE 1 (residues 1 to 80) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 80) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 80) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 80) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12296. Method: conceptual translation. FEATURES Location/Qualifiers source 1..80 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..80 /product="Cmi8p" /calculated_mol_wt="8972" CDS 1..80 /gene="CMI8" /locus_tag="YDR461C-A" /coded_by="NM_001184679.1:1..243" /note="Putative cytosolic hypothetical protein" /db_xref="GeneID:3799972" /db_xref="SGD:S000087209" ORIGIN 1 mdsgksdink hayketatpl pvdppsyeet mkqdkeevea dettssahrd sfmrpvythh 61 phprshkgyp gaktltytsr // LOCUS NP_010750 147 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL40 MRPL28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010750 VERSION NP_010750.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180770.1 REFERENCE 1 (residues 1 to 147) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 147) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 147) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 147) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12297. Method: conceptual translation. FEATURES Location/Qualifiers source 1..147 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..147 /product="mitochondrial 54S ribosomal protein mL40 MRPL28" /calculated_mol_wt="17211" Region 27..137 /region_name="MRP-L28" /note="Mitochondrial ribosomal protein L28; pfam09812" /db_xref="CDD:430845" CDS 1..147 /gene="MRPL28" /locus_tag="YDR462W" /gene_synonym="mL40" /coded_by="NM_001180770.1:1..444" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852073" /db_xref="SGD:S000002870" ORIGIN 1 mlaqtfkkph ravleqvsgt tvfirnkrtk sksslsplaq rvvtqlsvms asrkqpkllk 61 laredlikhq tiekcwsiyq qqqrerrnlq lelqyksier smnllqelsp rlfeaanase 121 kgkrfpmemk vptdfppntl whynfrk // LOCUS NP_010751 519 aa linear PLN 30-JUN-2025 DEFINITION Stp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010751 VERSION NP_010751.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180771.3 REFERENCE 1 (residues 1 to 519) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 519) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 519) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 519) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12298. On Jul 30, 2012 this sequence version replaced NP_010751.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..519 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..519 /product="Stp1p" /calculated_mol_wt="57957" Region 160..182 /region_name="zf-C2H2" /note="Zinc finger, C2H2 type; pfam00096" /db_xref="CDD:395048" Region 162..182 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(162,165,178,182) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275368" Region 190..220 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..519 /gene="STP1" /locus_tag="YDR463W" /gene_synonym="BAP1; SSY2" /coded_by="NM_001180771.3:1..1560" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11212916]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:19906648|PMID:11212916]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21127045|PMID:1588961]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21127045]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21127045]" /experiment="EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:11212916]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11212916|PMID:19906648]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10648791]" /note="Transcription factor; contains a N-terminal regulatory motif (RI) that acts as a cytoplasmic retention determinant and as an Asi dependent degron in the nucleus; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication" /db_xref="GeneID:852074" /db_xref="SGD:S000002871" ORIGIN 1 mpsttllfpq khiraipgki yaffrelvsg viiskpdlsh hyscenatke egkdaadeek 61 tttslfpesn nidrslnggc svipcsmdvs dlntpisitl spenriksev naksllgsrp 121 eqdtgapikm stgvtsspls psgstpehst kvlnngeeef ichycdatfr irgyltrhik 181 khaiekayhc pffnsatppd lrchnsggfs rrdtykthlk arhvlypkgv kpqdrnkssg 241 hcaqcgeyfs tienfvenhi esgdckalpq gytkknekrs gklrkiktsn ghsrfistsq 301 svvepkvlfn kdaveamtiv annssgndii skygnnklml nsenfkvdip krkrkyikkk 361 qqqvsgstvt tpevatqnnq evapdeissa tifspfdthl lepvpsssse ssaevmfhgk 421 qmknflidin sftnqqqqaq dnpsflpldi eqssydlsed amsypiistq snrdctqydn 481 tkisqilqsq lnpeylsenh mretqqylnf yndnfgsqf // LOCUS NP_010752 1435 aa linear PLN 30-JUN-2025 DEFINITION Spp41p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010752 VERSION NP_010752.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180772.3 REFERENCE 1 (residues 1 to 1435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1435) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12299. On Jul 30, 2012 this sequence version replaced NP_010752.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1435 /product="Spp41p" /calculated_mol_wt="161467" Region 1310..1358 /region_name="DUF3020" /note="SPP41, DUF3020; pfam11223" /db_xref="CDD:402691" CDS 1..1435 /gene="SPP41" /locus_tag="YDR464W" /coded_by="NM_001180772.3:1..4308" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:8005438]" /note="hypothetical protein; involved in negative regulation of expression of spliceosome components PRP4 and PRP3; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852075" /db_xref="SGD:S000002872" ORIGIN 1 maydeddgei nfnelvgnll sshnqegqee gevqggeqeg ddfekiypts eniepkhpdd 61 sqhmhnspdq nieiphfvde edelvsvvan avqniddeqa kpenhlengs ehvtsdtadd 121 nhekeqqqew ahilqqeilk sdgeplrent errvstsqhh psqrtddald qddenlrmai 181 leslqelntn eeeekepekh ehaapndkls skksskkkkk dksknressk dksskkskss 241 shskkhakdr nkekqskptn nentldlsni lenlihendn aaidtakqtv diqdnshtdn 301 tnnedveaqa lveatlkafe nellssapte epsqeqsigp vssrkavepp rkptaddipl 361 amlqafkpkk rppqekkktk sktskaasta nkspasests kkkkkkktvk esnksqeaye 421 ddefsrilad mvnqvvntsl ketsthtatq dnklesesdf tspvqsqytt edastandds 481 ldlnqimqna mamvfqnqnd defdenived fnrglgdlsv sdllphdnls rmekksvpks 541 ssksekktai srraskkasr dassveltev pskpkkpskt evslekklrk kyvsianeaa 601 svarkkrwak nkelkekekl erqtareerr hkkklekqrl aeeqeelkki vergppyppd 661 lrltksgkpk kpyrrwtpee llkrsqeaek prkvkkerkk kekkmkvpss alkkiplfnf 721 vkgnvqpsar hrlndiegsl stiglhkspd gvrrilsrpk sedhewplsd ssasqnydah 781 lktvvhkeki pfhppwtips qppfalpvar rkkipnikky rkrtnnsfrv skegtastrn 841 rilpaillpi intlkaaaks qtaagatpee arkrlatiiq hakstviraa lqarknsmqa 901 ahskgtttel attasrmknp lkmipifnts rvkqqldkql parsagteis ssespdkatp 961 dphsnstiag htlkgvttpi kiedsdanvp pvsiavstie psqdkleltk raesvepven 1021 nvetaketqs vqeikenvgt kaseevtlte dktngdpkne kriliespve ktdkkkpgek 1081 iatdlnedas lsdkkdgdek stlhsdaaql tgnepdsvnt ttgkpklidv slkplneakp 1141 kipiifplkr pqikpevsvi nlvqnlvntk ipeiknesvd lgsnitdils stitnilpei 1201 tatdvknyqy edenvkylkk tprqvlnldg lvppsgrcit kakrvrrikk lsadattape 1261 adgkansesi tytfdipspe evqskrsvvl kfakarltea elsclkkein nvrkrrwrem 1321 nstknweydv ksrlkkrana ffgegesetk skwieerfqe kvsqekykdr lettetqann 1381 tkividdkei lnilavnmnn lnkarciekd iqesfreekl aslqpkkkrk ksilh // LOCUS NP_010753 412 aa linear PLN 30-JUN-2025 DEFINITION protein-arginine N5-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010753 VERSION NP_010753.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180773.1 REFERENCE 1 (residues 1 to 412) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 412) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 412) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 412) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12300. Method: conceptual translation. FEATURES Location/Qualifiers source 1..412 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..412 /product="protein-arginine N5-methyltransferase" /calculated_mol_wt="47338" Region 244..345 /region_name="AdoMet_MTases" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cd02440" /db_xref="CDD:100107" Site order(248..254,271..272,296..298,319) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..412 /gene="RMT2" /locus_tag="YDR465C" /coded_by="NM_001180773.1:1..1239" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095|PMID:17448464]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095|PMID:17448464]" /experiment="EXISTENCE:direct assay:GO:0018216 peptidyl-arginine methylation [PMID:11856739]" /experiment="EXISTENCE:direct assay:GO:0019702 protein arginine N5-methyltransferase activity [PMID:11856739]" /experiment="EXISTENCE:mutant phenotype:GO:0018216 peptidyl-arginine methylation [PMID:9873020]" /experiment="EXISTENCE:mutant phenotype:GO:0019702 protein arginine N5-methyltransferase activity [PMID:9873020]" /note="Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:852076" /db_xref="SGD:S000002873" ORIGIN 1 mselhalltf perpisqsyy vpklqhflks gipatytleq vaafeheekn rngdkefres 61 tddnktsntt plhvlarslp ldikdeelqv vmdmmnilfe ygagwnfidy edktvgdlfl 121 ernqsrespl yrrlveagvs aelllrklng gdvefldtde ligiepeesv qtavdgqkee 181 svgsdddata anqqvylkte leykddalit kenkdgvmmd wetkimelas etlfpdpeat 241 nsatilnigf gmgiidtfiq arkpyrhyic eahpdvlakm kmdgwyekdn vvilegrwqd 301 tlnnlldkge vffdgiyydt fsehyqdild lydvvvglik pegvfsffng lgadrslcyd 361 vykeiveidv atygmkcdyt rysldeqlpd wndvkrsyfn cnyyyhprit fa // LOCUS NP_010754 898 aa linear PLN 30-JUN-2025 DEFINITION protein kinase PKH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010754 VERSION NP_010754.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180774.1 REFERENCE 1 (residues 1 to 898) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 898) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 898) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 898) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12301. Method: conceptual translation. FEATURES Location/Qualifiers source 1..898 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..898 /product="protein kinase PKH3" /EC_number="2.7.11.1" /calculated_mol_wt="100345" Region 9..293 /region_name="STKc_PDK1" /note="Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; cd05581" /db_xref="CDD:270733" Site order(17..21,25,39,41,76,92..93,95,99,101,138,140,142..143, 145,155..156,159,190..195,222,228,231) /site_type="active" /db_xref="CDD:270733" Site order(17..20,23,25,39,41,60,76,92..95,98..99,142..143,145, 155..156) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270733" Site order(21,99,101,138,140,142,159,190..195,222,228,231) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270733" Site order(155..165,187..195) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270733" CDS 1..898 /gene="PKH3" /locus_tag="YDR466W" /coded_by="NM_001180774.1:1..2697" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:10567559]" /note="Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p; yeast Pkh1p and Pkh2p are two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant" /db_xref="GeneID:852077" /db_xref="SGD:S000002874" ORIGIN 1 mtsrkrsphd fifkeelghg systvfkald kkspnkiyai kvcskkhiik eakvkyvtie 61 kntmnllaqk hhagiiklyy tfhdeenlyf vldfapggel lsllhkmgtf ndiwtrhfta 121 qlidalefih shgiihrdlk penvlldrdg rlmitdfgaa atidpslsgd sakfnsdsng 181 skdnqncasf vgtaeyvspe lllynqcgyg sdiwalgcmi yqfvqgqppf rgenelktfe 241 kivaldypwg pnnrinnsts pinplvinlv qkilvievne risleqikrh pyfskvdwnd 301 kikiwrgiwq sqgqslqqtt lglpnipqni lptrqlhvid tparsiqitk qkrkkptkis 361 nttssivvwr krlgistgkd dlgtvpsttp avtapndtnv ltntaahsta nialppnsqs 421 nqvkraqlva pnrippkvpv indnvrnksi prtkpnvppl qtssipqkls tssassalsa 481 psteirnqdl thtldgrnsi dihvlkqdyv fiygipyehe gpamslnsyn kidndlitsl 541 vaqhkeelkn sesflqvltl kksgmlsykn tvmegnddqe nkehqmanie dtdlsmydfe 601 fneltrkgfl ilekyknriw fislpsystl skipfnavks stinnnenwv dcffrarqll 661 eekqildkis nvsfdskass epsspppisr kerplsignn vttlsytakn gsqnnapqnd 721 nvgeekpfri psstkdrpga nstpssrhpr vlssnnaget pkkmngrlpn sapstntytn 781 gsvpafnhrp stnvgnnkhn iltskkqgss vfspsssttk pqikttgyrq ptpspplpqm 841 efpttrekys apsnmvisss ryevlhtlnn sqtnfdreia srgasaafrs lqkskkkk // LOCUS NP_010756 224 aa linear PLN 30-JUN-2025 DEFINITION Tlg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010756 VERSION NP_010756.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180776.3 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12302. On Jul 30, 2012 this sequence version replaced NP_010756.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..224 /product="Tlg1p" /calculated_mol_wt="25686" Region 6..92 /region_name="SNARE_NTD_Tlg1p-like" /note="N-terminal domain of t-SNARE affecting a late Golgi compartment protein 1 and similar proteins; cd21444" /db_xref="CDD:410570" Site order(6,8..9,12,15..16,19..20,22..23,26..27,29..30,38,41, 45,49,52,55..56,59,62..63,70,73..74,76..77,79..81,83..84, 87..88,90..91) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:410570" Site order(7,10..11,14,18,21,25,29,37,40..41,43..44,47,50..51, 54..55,57..58,61,64) /site_type="other" /note="Vsp51 binding site [polypeptide binding]" /db_xref="CDD:410570" Region 135..200 /region_name="SNARE_Syntaxin6" /note="SNARE motif of syntaxin 6; cd15851" /db_xref="CDD:277204" Site order(139..142,144..146,148..150,152..153,155..160, 162..163,165..166,169..170,172..174,176..178,180..181, 183..184,187..188,190..191,193) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277204" Site 166 /site_type="other" /note="zero layer" /db_xref="CDD:277204" CDS 1..224 /gene="TLG1" /locus_tag="YDR468C" /coded_by="NM_001180776.3:1..675" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:14981247]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:9427746]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:15973437]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11739407]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:9427746]" /experiment="EXISTENCE:physical interaction:GO:0031201 SNARE complex [PMID:10397773]" /note="Essential t-SNARE that mediates fusion of vesicles with the late Golgi; forms a complex with Tlg2p and Vti1p; mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p" /db_xref="GeneID:852079" /db_xref="SGD:S000002876" ORIGIN 1 mnnsedpfqq vvkdtkeqln rinnyitrhn tagdddqeee iqdilkdvee tivdldrsii 61 vmkrdenedv sgreaqvkni kqqldalklr fdrriqestq ttipleetve nstlntsmae 121 nndggmsnpf qeqmlreqdv hldgihktmq nlhiqaqtmg delenqgqll dnmdegmdgv 181 vnklargrrq lewvyeknke kyddccigll ivvlivllvl afia // LOCUS NP_010757 175 aa linear PLN 30-JUN-2025 DEFINITION Sdc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010757 VERSION NP_010757.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180777.3 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12303. On Jul 30, 2012 this sequence version replaced NP_010757.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..175 /product="Sdc1p" /calculated_mol_wt="19315" Region 122..162 /region_name="DD_DPY30_SDC1" /note="dimerization/docking (D/D) domain found in the DPY30/SDC1 family; cd22965" /db_xref="CDD:438534" Site order(122,125..126,129..130,133,138,141,145..146,149..151, 153..154,157..158) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:438534" Site order(122..123,127..128,130..131,135,138..139,142..143) /site_type="other" /note="Bre2 binding site [polypeptide binding]" /db_xref="CDD:438534" CDS 1..175 /gene="SDC1" /locus_tag="YDR469W" /gene_synonym="CPS25; SAF19" /coded_by="NM_001180777.3:1..528" /experiment="EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11805083|PMID:11742990]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11805083|PMID:11752412|PMID:11687631]" /experiment="EXISTENCE:mutant phenotype:GO:0042800 histone H3K4 methyltransferase activity [PMID:11805083|PMID:11752412]" /experiment="EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11687631|PMID:11752412|PMID:11742990]" /note="Subunit of the COMPASS (Set1C) complex; COMPASS methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30" /db_xref="GeneID:852080" /db_xref="SGD:S000002877" ORIGIN 1 mnesenspqh nevtvpmved tssnadipme qiqrednkny dkhdnecfdm ngnhnnnsdn 61 lqfdsvpssa tkdlkniksv tnqnvkiees sstnsviees sepkisklen vnlaatvggs 121 qtrkylntnv tphllagmrl iavqqpedpl rvlgeylieq snilksgeke snask // LOCUS NP_010758 502 aa linear PLN 30-JUN-2025 DEFINITION mitofusin complex protein UGO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010758 VERSION NP_010758.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180778.2 REFERENCE 1 (residues 1 to 502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 502) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12304. On Apr 26, 2011 this sequence version replaced NP_010758.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..502 /product="mitofusin complex protein UGO1" /calculated_mol_wt="57412" CDS 1..502 /gene="UGO1" /locus_tag="YDR470C" /coded_by="NM_001180778.2:1..1509" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:19237599]" /experiment="EXISTENCE:mutant phenotype:GO:0008053 mitochondrial fusion [PMID:12808034|PMID:11257114]" /note="Outer membrane component of the mitochondrial fusion machinery; binds to Fzo1p and Mgm1p to link these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo1p during fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but likely not a transporter; similar to human SLC25A46 implicated in optic atroprophy spectrum disorder and Leigh syndrome" /db_xref="GeneID:852081" /db_xref="SGD:S000002878" ORIGIN 1 mnnnnvteat sraqirpyyd pdsfnagysa vfkpdegvvd phgytiaskl nvinsspttk 61 rmanalfkss pmkklsnsvn dglslegsng eitglnnfew aelvniqkwr kifeqlldmf 121 frkyfqlliq qpfdvarlli qvgefkifkt tvdtnkpqap iilrdeegdg aaregeeday 181 deeeidffpi erkiaeanst apimaeetdh shheptdisl tiapqslhti dvinalfdqe 241 girglwkann ttfiynflsl sidtwftgll ssflgvpdpy fmevinspdi sksfilalga 301 gvftsiillp vdlirtrliv tsfkkkknvk tdgknmvtnt rslrqlircw swrkngvsip 361 ldmwsltilq sinnsffnkl fdlviynqfh iekysqtvmy ntmkffsksl elfiklplen 421 llrrcqlnyl lndqrlsfkv dstelivkpk kyngiwdvir nnsntnrgql wngwkvgvis 481 licgyglqmm nkvdinmeqe kf // LOCUS NP_010759 136 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL27 RPL27B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010759 VERSION NP_010759.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180779.1 REFERENCE 1 (residues 1 to 136) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 136) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 136) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 136) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12305. Method: conceptual translation. FEATURES Location/Qualifiers source 1..136 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..136 /product="60S ribosomal protein eL27 RPL27B" /calculated_mol_wt="15374" Region 1..136 /region_name="KOW" /note="an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); cl00354" /db_xref="CDD:469738" Site order(7..15,18,22..29,42..47,52..54,56,59..61,67) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240514" CDS 1..136 /gene="RPL27B" /locus_tag="YDR471W" /coded_by="NM_001180779.1:1..411" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:23212245]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:23212245]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23212245]" /note="Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication" /db_xref="GeneID:852082" /db_xref="SGD:S000002879" ORIGIN 1 makflkagkv avvvrgryag kkvvivkphd egskshpfgh alvagieryp skvtkkhgak 61 kvakrtkikp fikvvnynhl lptrytldve afksvvstet feqpsqreea kkvvkkafee 121 rhqagknqwf fsklrf // LOCUS NP_010760 283 aa linear PLN 30-JUN-2025 DEFINITION TRAPP subunit TRS31 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010760 VERSION NP_010760.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180780.3 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12306. On Jul 30, 2012 this sequence version replaced NP_010760.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..283 /product="TRAPP subunit TRS31" /calculated_mol_wt="31591" Region 9..280 /region_name="COG5128" /note="Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion]" /db_xref="CDD:227457" CDS 1..283 /gene="TRS31" /locus_tag="YDR472W" /coded_by="NM_001180780.3:1..852" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17110339]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990070 TRAPPI protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990072 TRAPPIII protein complex [PMID:20375281]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10727015]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11239471]" /note="Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII)" /db_xref="GeneID:852083" /db_xref="SGD:S000002880" ORIGIN 1 msqriiqpsa sdqqfpgksd gyeytvgpkq aitseastty ipsriysesl lfkrqeasls 61 amaflfqemi sqlhrtckta gdfetklsdy ghnigirlle llnfrasvsp sslprasafl 121 sqnessskls nasnspgmla nsstatsasa nerlqekqte slsnyitkmr rrdlkildil 181 qfihgtlwsy lfnhvsddlv ksserdneym ivdnfptltq fipgenvsce yfvcgiikgf 241 lfnagfpcgv tahrmpqggh sqrtvyliqf drqvldregl rfg // LOCUS NP_010761 469 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit PRP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010761 VERSION NP_010761.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180781.3 REFERENCE 1 (residues 1 to 469) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 469) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 469) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 469) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12307. On Jul 30, 2012 this sequence version replaced NP_010761.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..469 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..469 /product="U4/U6-U5 snRNP complex subunit PRP3" /calculated_mol_wt="55739" Region 67..317 /region_name="PRP3" /note="pre-mRNA processing factor 3 (PRP3); pfam08572" /db_xref="CDD:462524" Region 337..456 /region_name="Prp3_C-like" /note="C-terminal domain of Prp3 and related proteins; cd24140" /db_xref="CDD:467812" CDS 1..469 /gene="PRP3" /locus_tag="YDR473C" /gene_synonym="RNA3" /coded_by="NM_001180781.3:1..1410" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:mutant phenotype:GO:0000387 spliceosomal snRNP assembly [PMID:9326489]" /note="Splicing factor; component of the U4/U6-U5 snRNP complex" /db_xref="GeneID:852084" /db_xref="SGD:S000002881" ORIGIN 1 mpprntyekg npkrqnspyy kpsflrreet tndeekfqgh glktelhsal kssnlnlirr 61 tyqtgenpyl sdphdrgsss rfnrryergl kfyqkgeisk riaqertlqk qqeeeelkrk 121 lkqeedekdk rkliesgdlp nlelhedkfl ldlskfkiyy dnnhgyewwd tayldekgel 181 mekydmngts paeeklaedi devdddddde hpsiryvahp lpekineakv sikayltqhe 241 rkrlrrnrrk mareareiki klgllpkpep kvklsnmmsv fendqnitdp tawekvvkdq 301 vdlrkrkhle enerrhedai krrkeavnmn vekptvyhck vfqfknlqnp kirfklkmns 361 kelslkglcl rirddgpgii ivvgneksck fyenlvmkri kwnedfelht ntgdikmdmh 421 nnsisktweg ylqdckfkgw fmkvcndqds llrtlgqfds ehfyspvqt // LOCUS NP_010763 876 aa linear PLN 30-JUN-2025 DEFINITION Jip4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010763 VERSION NP_010763.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180783.1 REFERENCE 1 (residues 1 to 876) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 876) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 876) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 876) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12308. On Oct 2, 2003 this sequence version replaced NP_010763.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..876 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..876 /product="Jip4p" /calculated_mol_wt="98560" CDS 1..876 /gene="JIP4" /locus_tag="YDR475C" /gene_synonym="YDR474C" /coded_by="NM_001180783.1:1..2631" /note="hypothetical protein; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence; JIP4 has a paralog, YOR019W, that arose from the whole genome duplication" /db_xref="GeneID:852086" /db_xref="SGD:S000002883" ORIGIN 1 mvvrdqdeal rnsykyvkly vrqdqledtv dilakqdedk snnddrrsla sildssssvk 61 kkgkgsneky lpcvsfntvp rsrvssplde ekrefpgvqi sadytmeeyy ddesgftsdn 121 nadyfsgnsy ssrregsasp grysspppas krnikigkmf kisengkivr edypttptdi 181 ndalvisray anwrqlwikk knqidhrleq krdffnypti lfppnkkkss egatptikfn 241 ppiedgftpl tksqkrkerv lsekvgfpnt prtilchisg rkhtwvaldw alrtliqntd 301 hivvlanlpr ltknnfednd smserkrmlm mmddsrsvss arrsrsrsrs rsictrrals 361 lgpeesdnkl khqnfiewts gytqneierk lqdlfdyvtl iipqdrsvkv tveiligktk 421 ktlleainiy lpdffvsstl rwertdslvr wksnfltdkl ctnfpiptfi vpakrmfdle 481 idlqkefkep evtkqkntsg pkpgfshsks adasiptisn ikrkqdndys idslcyapea 541 ngannssree asddelnafk ddendvmsvk sltsnisvke klctmarkrr ksmaqqlnda 601 dhdssippgq rhlkklniil esslkfslei dsitdsieng dvdekrahsm esgfeelkrv 661 itggapprhv atpqrsmldv ldnpsssrsk sksrsssksr irdkskpssp tatdinssas 721 asrsrspqik fassvknvdg naalgaiksr hsldspgdqq qqhhhhhhrd tdqlsvpglp 781 hlapsksysv ssgnkdsslr kvssssslrk vksndsnsgk rikkpvvtsa hlkpssgggg 841 lfsffksksr spssfrkede skntpkrggl fgfgrl // LOCUS NP_010764 224 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR476C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010764 VERSION NP_010764.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180784.1 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12309. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..224 /product="uncharacterized protein" /calculated_mol_wt="25135" CDS 1..224 /locus_tag="YDR476C" /coded_by="NM_001180784.1:1..675" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene" /db_xref="GeneID:852087" /db_xref="SGD:S000002884" ORIGIN 1 mwdslivsin dthklgledc lavfghvpit kavkhvrlte idtqtstftl kflhtetgqn 61 iekiiyfidn dtgndtrtat gikqifnkmf riaaekrkls liqidtveyp ctlvdllilv 121 gvalpplcyl yrpalhaiff lvpnpvgstl eawldsdlvl rliivaeflt haletlifvv 181 prlkyyrvpg efvpewlllg llegygparr ldtkartlge gsvn // LOCUS NP_010765 633 aa linear PLN 30-JUN-2025 DEFINITION AMP-activated serine/threonine-protein kinase catalytic subunit SNF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010765 VERSION NP_010765.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180785.3 REFERENCE 1 (residues 1 to 633) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 633) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 633) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 633) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12310. On Jul 30, 2012 this sequence version replaced NP_010765.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..633 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..633 /product="AMP-activated serine/threonine-protein kinase catalytic subunit SNF1" /EC_number="2.7.11.1" /calculated_mol_wt="71915" Region 52..306 /region_name="STKc_AMPK_alpha" /note="Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase; cd14079" /db_xref="CDD:270981" Site order(61..65,69,82,84,116,132..135,138,140..141,143, 176..177,179,181..182,184,194..195,198,212..216,218, 248..251) /site_type="active" /db_xref="CDD:270981" Site order(61..64,69,82,84,116,132..135,138,181..182,184, 194..195) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270981" Site order(138,140..141,143,177,179,181,198,212..216,218, 248..251) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270981" Site 194..216 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270981" Site order(202..207,226..227,229,232,292) /site_type="other" /note="heterotrimer interface [polypeptide binding]" /db_xref="CDD:270981" Region 344..389 /region_name="UBA_2" /note="Ubiquitin associated domain (UBA); pfam08587" /db_xref="CDD:430091" Site order(503..508,515..516,520,523..524,527,531..533,535..538, 542,545..547,567,571..575,580..581,583..586,610,612..613, 615..617,619..620,623..624) /site_type="other" /note="beta subunit interface [polypeptide binding]" /db_xref="CDD:213378" Region 504..626 /region_name="AdenylateSensor" /note="Adenylate sensor of SNF1-like protein kinase; pfam16579" /db_xref="CDD:406881" Site order(550,552,610..611,613..614,617) /site_type="other" /note="gamma subunit interface [polypeptide binding]" /db_xref="CDD:213378" CDS 1..633 /gene="SNF1" /locus_tag="YDR477W" /gene_synonym="CAT1; CCR1; GLC2; HAF3; PAS14" /coded_by="NM_001180785.3:1..1902" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:29643469]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:27524664|PMID:7913470|PMID:11486005|PMID:2557546]" /experiment="EXISTENCE:direct assay:GO:0004679 AMP-activated protein kinase activity [PMID:38224949]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:26198097]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17237508]" /experiment="EXISTENCE:direct assay:GO:0005641 nuclear envelope lumen [PMID:17237508]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17237508]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:14966266]" /experiment="EXISTENCE:direct assay:GO:0031588 nucleotide-activated protein kinase complex [PMID:2481228|PMID:12393914]" /experiment="EXISTENCE:direct assay:GO:0042149 cellular response to glucose starvation [PMID:11486005|PMID:7913470|PMID:26198097]" /experiment="EXISTENCE:genetic interaction:GO:0000132 establishment of mitotic spindle orientation [PMID:29643469]" /experiment="EXISTENCE:genetic interaction:GO:0017148 negative regulation of translation [PMID:18955495]" /experiment="EXISTENCE:genetic interaction:GO:2000222 positive regulation of pseudohyphal growth [PMID:12024013]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:29643469]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12556493|PMID:11095711]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:27524664]" /experiment="EXISTENCE:mutant phenotype:GO:0004679 AMP-activated protein kinase activity [PMID:11486005|PMID:2557546|PMID:7913470]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:25730376]" /experiment="EXISTENCE:mutant phenotype:GO:0010920 negative regulation of inositol phosphate biosynthetic process [PMID:38224949]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:11486014]" /experiment="EXISTENCE:mutant phenotype:GO:0017148 negative regulation of translation [PMID:18955495]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:24486034]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:32005698]" /experiment="EXISTENCE:mutant phenotype:GO:0045722 positive regulation of gluconeogenesis [PMID:9111319|PMID:8628258|PMID:8710504]" /experiment="EXISTENCE:mutant phenotype:GO:0071940 fungal-type cell wall assembly [PMID:24486034]" /experiment="EXISTENCE:mutant phenotype:GO:0090606 single-species surface biofilm formation [PMID:12024013]" /experiment="EXISTENCE:mutant phenotype:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:22904036]" /experiment="EXISTENCE:mutant phenotype:GO:2000222 positive regulation of pseudohyphal growth [PMID:12024013]" /experiment="EXISTENCE:physical interaction:GO:0031588 nucleotide-activated protein kinase complex [PMID:2481228|PMID:9121458]" /note="AMP-activated S/T protein kinase (AMPK); complexes with Snf4p and a Sip1p/Sip2p/Gal83p family member; required for glucose-shortage induced respiratory gene expression, heat shock, sporulation, and peroxisome biogenesis; regulates filamentous growth; acts as a non-canonical GEF activating Arf3p during invasive growth; role in mitotic spindle alignment in non-limiting glucose; phosphorylates Kcs1p; target of SUMO-dependent, Ub-mediated destruction; polyhistidine tract acts as a pH sensing module" /db_xref="GeneID:852088" /db_xref="SGD:S000002885" ORIGIN 1 mssnnntnta panansshhh hhhhhhhhhh ghggsnstln npkssladga hignyqivkt 61 lgegsfgkvk layhtttgqk valkiinkkv laksdmqgri ereisylrll rhphiiklyd 121 vikskdeiim vieyagnelf dyivqrdkms eqearrffqq iisaveychr hkivhrdlkp 181 enllldehln vkiadfglsn imtdgnflkt scgspnyaap evisgklyag pevdvwscgv 241 ilyvmlcrrl pfddesipvl fknisngvyt lpkflspgaa glikrmlivn plnrisihei 301 mqddwfkvdl peyllppdlk phpeeenenn dskkdgsspd ndeiddnlvn ilsstmgyek 361 deiyesless edtpafneir daymlikenk slikdmkank svsdeldtfl sqspptfqqq 421 skshqksqvd hetakqharr masaitqqrt yhqspfmdqy keedstvsil ptslpqihra 481 nmlaqgspaa skisplvtkk sktrwhfgir srsypldvmg eiyialknlg aewakpseed 541 lwtiklrwky dignktntne kipdlmkmvi qlfqietnny lvdfkfdgwe ssygddttvs 601 nisedemstf saypflhltt klimelavns qsn // LOCUS NP_010766 198 aa linear PLN 30-JUN-2025 DEFINITION Snm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010766 VERSION NP_010766.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180786.3 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12311. On Jul 30, 2012 this sequence version replaced NP_010766.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..198 /product="Snm1p" /calculated_mol_wt="22410" Region 18..109 /region_name="Rpr2" /note="RNAse P Rpr2/Rpp21/SNM1 subunit domain; pfam04032" /db_xref="CDD:427665" CDS 1..198 /gene="SNM1" /locus_tag="YDR478W" /coded_by="NM_001180786.3:1..597" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:17881380]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:7958920]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:10523674]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:22977255]" /experiment="EXISTENCE:mutant phenotype:GO:0030541 plasmid partitioning [PMID:10523674]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380|PMID:11880623|PMID:7958920]" /note="Ribonuclease MRP complex-specific subunit; ribonuclease (RNase) MRP cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds and assists in the folding of NME1, the RNase MRP RNA, to form the substrate-binding module; structural similarity but limited sequence homology with human RMP24 (c18orf21)" /db_xref="GeneID:852089" /db_xref="SGD:S000002886" ORIGIN 1 mnkdqaekyq erslrqkynl lhvlptlnsr alsglyyknf hnsvkryqim lpeqlksgkf 61 cshcgcvyvp nfnaslqltt nteqgdsdel ggesmegpkk ciqvnclnce ksklfewkse 121 fvvptfgqdv spminstssg kvsyavkkpq ksktstgker skkrklnslt nllskrnqek 181 kmekkksssl slesfmks // LOCUS NP_010767 554 aa linear PLN 30-JUN-2025 DEFINITION Pex29p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010767 VERSION NP_010767.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180787.1 REFERENCE 1 (residues 1 to 554) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 554) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 554) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12312. Method: conceptual translation. FEATURES Location/Qualifiers source 1..554 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..554 /product="Pex29p" /calculated_mol_wt="63412" Region 115..465 /region_name="Pex24p" /note="Integral peroxisomal membrane peroxin; pfam06398" /db_xref="CDD:399414" CDS 1..554 /gene="PEX29" /locus_tag="YDR479C" /coded_by="NM_001180787.1:1..1665" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27129769]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:12707309]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:27129769|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0007031 peroxisome organization [PMID:12707309]" /experiment="EXISTENCE:genetic interaction:GO:0032581 ER-dependent peroxisome organization [PMID:27129769]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:12707309]" /note="ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex30p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenesis from the ER; role in peroxisomal-destined vesicular flow from the ER; regulates peroxisomal size, number and distribution; Pex28p and Pex29p may act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress" /db_xref="GeneID:852090" /db_xref="SGD:S000002887" ORIGIN 1 mdsvtnffwn dtynagtptr stlkgkkvqn gidgksqakk esissgsrts dptrgslpss 61 sgqptsgggf pstsniqkmm adtlvekiik malppsskta vdtihhrmva gkerpklsvq 121 itsrnfiqmn srlgvpfmim delikilnwt npaytvsimf lytliilkpf qmlsslpify 181 llfcvmvpqy lyihkpnpts yldnnqtpaq gpplrrpevp kpvpelsqef vlnltdlqnh 241 mllyvkfydf tllilqkfaf ftneaissfy fivlliiatl nflymdkfik lipmrpvlil 301 lgwgffiash psnreylltk lnseetrlkt ltistnlesk ilqhlkliea rehrlvmife 361 iqkylpeyke wrpvgfsddd yslfsslriy qrrieensvk sleeieppkd weweanshwv 421 ldldpkewve defiqyveid setkwvydln ldgqrgsyrr rmwtnscvrk kldsgissnl 481 geeevvnplr eetyrqgvhg vtkgsmsggl thssdddrad eesingtipn lnnidadasy 541 psieeltdtl nsti // LOCUS NP_010768 323 aa linear PLN 30-JUN-2025 DEFINITION Dig2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010768 VERSION NP_010768.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180788.1 REFERENCE 1 (residues 1 to 323) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 323) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 323) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 323) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12313. Method: conceptual translation. FEATURES Location/Qualifiers source 1..323 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..323 /product="Dig2p" /calculated_mol_wt="36748" CDS 1..323 /gene="DIG2" /locus_tag="YDR480W" /gene_synonym="RST2" /coded_by="NM_001180788.1:1..972" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:10825185]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9094309]" /experiment="EXISTENCE:direct assay:GO:1990526 Ste12p-Dig1p-Dig2p complex [PMID:16782869]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9860980|PMID:9094309]" /experiment="EXISTENCE:genetic interaction:GO:0071444 cellular response to pheromone [PMID:9860980|PMID:9094309]" /experiment="EXISTENCE:genetic interaction:GO:2000218 negative regulation of invasive growth in response to glucose limitation [PMID:8918885|PMID:9094309]" /experiment="EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:8918885|PMID:9094309]" /note="MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG2 has a paralog, DIG1, that arose from the whole genome duplication" /db_xref="GeneID:852091" /db_xref="SGD:S000002888" ORIGIN 1 mnkeeqedpq qeqistvqen dprnlqqlgm llvspglded rlsekmiski kksrdieknq 61 kllisrlsqk eedhsgkppt ittspaektv pfkslnhslk rkrvppalnf sdiqasshlh 121 gsksappnit rfpqhknslr vrymgrmapt nqdyhpsvan symtatypyp ytglppvpcy 181 pysstptqth ayegyyspmy pgplynngii padyhakrkk lagrsphled ltsrkrtfvs 241 khhngdpiis ktdediecsv tknslsegas lnddadddnd keriiigeis lyddvfkfev 301 rddkndymka cetiwtewhn lkk // LOCUS NP_010769 566 aa linear PLN 30-JUN-2025 DEFINITION alkaline phosphatase PHO8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010769 VERSION NP_010769.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180789.3 REFERENCE 1 (residues 1 to 566) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 566) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 566) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 566) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12314. On Jul 30, 2012 this sequence version replaced NP_010769.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..566 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..566 /product="alkaline phosphatase PHO8" /EC_number="3.1.3.1" /EC_number="3.1.3.54" /EC_number="3.1.7.6" /calculated_mol_wt="62873" Region 66..527 /region_name="Alk_phosphatase" /note="Alkaline phosphatase; pfam00245" /db_xref="CDD:395188" Site order(75,122..123,176,187,325,330,334,373..374) /site_type="active" /db_xref="CDD:293736" Site order(75,122..123,187,330,334,374) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:293736" CDS 1..566 /gene="PHO8" /locus_tag="YDR481C" /coded_by="NM_001180789.3:1..1701" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:2676517]" /experiment="EXISTENCE:direct assay:GO:0004035 alkaline phosphatase activity [PMID:8499492]" /experiment="EXISTENCE:mutant phenotype:GO:0009166 nucleotide catabolic process [PMID:25468960]" /experiment="EXISTENCE:mutant phenotype:GO:0046496 nicotinamide nucleotide metabolic process [PMID:21349851]" /note="Repressible vacuolar alkaline phosphatase; controls polyphosphate content; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN" /db_xref="GeneID:852092" /db_xref="SGD:S000002889" ORIGIN 1 mmthtlpseq trlvpgsdss srpkkrrisk rskiivstvv ciglllvlvq lafpssfalr 61 sashkkknvi ffvtdgmgpa slsmarsfnq hvndlpiddi ltldehfigs srtrssdslv 121 tdsaagataf acalksynga igvdphhrpc gtvleaakla gyltglvvtt ritdatpasf 181 sshvdyrwqe dliathqlge yplgrvvdll mgggrshfyp qgekaspygh hgarkdgrdl 241 ideaqsngwq yvgdrknfds llkshgenvt lpflglfadn dipfeidrde keypslkeqv 301 kvalgaleka snedkdsngf flmvegsrid haghqndpas qvrevlafde afqyvlefae 361 nsdtetvlvs tsdhetgglv tsrqvtasyp qyvwypqvla nathsgeflk rklvdfvheh 421 kgasskienf ikheilekdl giydytdsdl etlihlddna naiqdklndm vsfraqigwt 481 thghsavdvn iyayankkat wsyvlnnlqg nhentevgqf lenflelnln evtdlirdtk 541 htsdfdatei asevqhydey yheltn // LOCUS NP_010770 135 aa linear PLN 30-JUN-2025 DEFINITION U2-type spliceosomal complex subunit CWC21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010770 VERSION NP_010770.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180790.3 REFERENCE 1 (residues 1 to 135) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 135) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 135) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 135) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12315. On Jul 30, 2012 this sequence version replaced NP_010770.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..135 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..135 /product="U2-type spliceosomal complex subunit CWC21" /calculated_mol_wt="15631" Region 62..109 /region_name="cwf21" /note="cwf21 domain; cl40451" /db_xref="CDD:424082" CDS 1..135 /gene="CWC21" /locus_tag="YDR482C" /coded_by="NM_001180790.3:1..408" /experiment="EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:19789211]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:19789211]" /note="Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p" /db_xref="GeneID:852093" /db_xref="SGD:S000002890" ORIGIN 1 msyngiglks akgsstsghv qrslasnnrr rpqgsqqqrq qrqnaikkas hdkasrplav 61 qkqiethmek reievqvsel rdrleeeetl seeqidkkce alrakltnew qeqqrmssly 121 tprkarltee qhrhe // LOCUS NP_010771 442 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,2-mannosyltransferase KRE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010771 VERSION NP_010771.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180791.1 REFERENCE 1 (residues 1 to 442) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 442) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 442) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 442) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12316. Method: conceptual translation. FEATURES Location/Qualifiers source 1..442 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..442 /product="alpha-1,2-mannosyltransferase KRE2" /calculated_mol_wt="51256" Region 35..438 /region_name="KTR1" /note="Mannosyltransferase [Carbohydrate transport and metabolism]; COG5020" /db_xref="CDD:227353" CDS 1..442 /gene="KRE2" /locus_tag="YDR483W" /gene_synonym="MNT1" /coded_by="NM_001180791.1:1..1329" /experiment="EXISTENCE:direct assay:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:1550992]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:7490293]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:1541391]" /experiment="EXISTENCE:mutant phenotype:GO:0006491 N-glycan processing [PMID:1495972]" /experiment="EXISTENCE:mutant phenotype:GO:0006493 protein O-linked glycosylation [PMID:1495972]" /note="Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication" /db_xref="GeneID:852094" /db_xref="SGD:S000002891" ORIGIN 1 malflskrll rftviagavi vllltlnsns rtqqyipssi saafdftsgs ispeqqvise 61 endakkleqs alnseaseds eamdeeskal kaaaekadap idtkttmdyi tpsfankagk 121 pkacyvtlvr nkelkgllss ikyvenkink kfpypwvfln depfteefke avtkavssev 181 kfgilpkehw sypewinqtk aaeiradaat kyiyggsesy rhmcryqsgf fwrhelleey 241 dwywrvepdi klycdinydv fkwmqenekv ygftvsihey evtiptlwqt smdfikknpe 301 yldennlmsf lsndngktyn lchfwsnfei anlnlwrspa yreyfdtldh qggffyerwg 361 dapvhsiaaa lflpkdkihy fsdigyhhpp ydncpldkev ynsnncecdq gndftfqgys 421 cgkeyydaqg lvkpknwkkf re // LOCUS NP_010772 641 aa linear PLN 30-JUN-2025 DEFINITION Vps52p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010772 VERSION NP_010772.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180792.1 REFERENCE 1 (residues 1 to 641) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 641) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 641) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 641) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 641) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 641) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 641) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 641) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 641) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12317. Method: conceptual translation. FEATURES Location/Qualifiers source 1..641 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..641 /product="Vps52p" /calculated_mol_wt="74202" Region 47..607 /region_name="Sec3_C" /note="Exocyst complex component Sec3; cl19950" /db_xref="CDD:418729" CDS 1..641 /gene="VPS52" /locus_tag="YDR484W" /gene_synonym="SAC2" /coded_by="NM_001180792.1:1..1926" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:10637310]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042147 retrograde transport, endosome to Golgi [PMID:12686613]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:10637310]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:12446664]" /experiment="EXISTENCE:mutant phenotype:GO:0030029 actin filament-based process [PMID:9153752]" /experiment="EXISTENCE:mutant phenotype:GO:0090156 intracellular sphingolipid homeostasis [PMID:26357016]" /experiment="EXISTENCE:physical interaction:GO:0000938 GARP complex [PMID:10637310]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12377769]" /note="Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; involved in localization of actin and chitin; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p" /db_xref="GeneID:852095" /db_xref="SGD:S000002892" ORIGIN 1 mdvlkevlsl dqdkfdqlke tsrdktnetd dpfenylkdc kfkapsnkdq spfaklkslq 61 ethsnneaai niiipqlidy lteftnrlsn ytqdldfikk ksnelqslle ynstklahis 121 pmvndlmipp eliddiikgk ineswqdnit fiadkeeiyn kyrsnnldqd nkdaensaml 181 apkdfdklcq lldilknvil erskrliisk iktlrshnpv psqriqnkll kvqkifpfir 241 dnnlslalel rqaycytmkw yyreyfsryi rsltilqfqq idsqfalgng lsttsvsgfn 301 nspslffsny lttsasnafy nklpvtdeki dkyfqikkrl niltqedntv mvsqiaennt 361 tknyieigfk nlnlaildnc tveyhflkdf famngdnfee inglleqifq ptfdeattyt 421 qqliqynydi fgvlisirva nqlqfeserr gipsmfdsfl ngqliqlwpr fqqlvdfqce 481 slrkaaittn vakyagnsst snsspltsph eltvqfgkfl ssfltlaith kqsidersep 541 lynsiirlrn dfetvmtkcs kktksperfl atnymylynn lqqlhlhlni ndsdaqnynf 601 dsaenvgtkv andddndssv pliiretenh fktlveaftr n // LOCUS NP_010773 795 aa linear PLN 30-JUN-2025 DEFINITION Vps72p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010773 VERSION NP_010773.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180793.3 REFERENCE 1 (residues 1 to 795) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 795) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 795) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 795) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 795) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 795) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 795) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 795) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 795) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12318. On Jul 30, 2012 this sequence version replaced NP_010773.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..795 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..795 /product="Vps72p" /calculated_mol_wt="90449" Region 21..292 /region_name="YL1" /note="YL1 nuclear protein; pfam05764" /db_xref="CDD:461734" Region 709..737 /region_name="YL1_C" /note="YL1 nuclear protein C-terminal domain; pfam08265" /db_xref="CDD:462412" CDS 1..795 /gene="VPS72" /locus_tag="YDR485C" /gene_synonym="SWC2" /coded_by="NM_001180793.3:1..2388" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:16299513|PMID:14645854|PMID:14690608]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:14690608|PMID:23580526]" /experiment="EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:16299513]" /note="Htz1p-binding component of the SWR1 complex; exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; may function as a lock that prevents removal of H2AZ from nucleosomes; required for vacuolar protein sorting" /db_xref="GeneID:852096" /db_xref="SGD:S000002893" ORIGIN 1 msdegadksl dtntefiiqt rsrrsnagnk lqklleqelr diestkrqis sykngnddee 61 deigllfqed eddedfemma kddddegeek edetqsirke psqasseqaa ddlmfssses 121 edssnended aeekeirrqe llsrkkrnkr lqkgpvvikk qkpkpksgea iprshhtheq 181 lnaetlllnt rrtskrssvm entmkvyekl skaekkrkii qerirkhkeq esqhmltqee 241 rlriaketek lnilsldkfk eqevwkkenr lalqkrqkqk fqpnetilqf lstawlmtpa 301 meledrkywq eqlnkrdkkk kkyprkpkkn lnlgkqdasd dkkreseesi kndgdvnslg 361 ensssvhnqk rieetstndt vegesspdaa vsrvnsdelk ptalpdvtld aiankqstvd 421 eapnsqpqkn iitneqkitn vgepiqnlhn eeikdemvsa lesrentfen sspaaqvvsq 481 rdnsatptps nstgtedtil ispdtdikge pepclktegi enlshnvpqe tksntdvsfl 541 kqvtftdhpq vaiidteesp skkdtanvde ssaenslstq tyegpeqlts rnfvtlydfp 601 nappnlkdfn tnlfgdrwsy tnglsatqrp qdmktvfhsi lpsppqssvp sptvdisldl 661 salanfpsfg eydkkivhqi nteinkdlei kiktqpptgv flangirkkc litnkecqyf 721 dprtgvpysd veaykiiqri qdpiskeegr sdikrdettn edsddqvrfk wfgfknggiy 781 ldlsqrpakg vpegf // LOCUS NP_010774 229 aa linear PLN 30-JUN-2025 DEFINITION Vps60p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010774 VERSION NP_010774.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180794.3 REFERENCE 1 (residues 1 to 229) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 229) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 229) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 229) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12319. On Jul 30, 2012 this sequence version replaced NP_010774.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..229 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..229 /product="Vps60p" /calculated_mol_wt="25731" Region 19..181 /region_name="Snf7" /note="pfam03357" /db_xref="CDD:460896" CDS 1..229 /gene="VPS60" /locus_tag="YDR486C" /gene_synonym="CHM5; MOS10" /coded_by="NM_001180794.3:1..690" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:23708375]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18032584]" /note="Protein involved in late endosome to vacuole transport; cytoplasmic and vacuolar membrane protein; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p" /db_xref="GeneID:852097" /db_xref="SGD:S000002894" ORIGIN 1 mnrifgygnk kshdqllqes nqsmnqaqqs lsnrisqldt qiaqlnfqlq niqknlqrsn 61 nkqpslrkqa lkilnkrkql enmkdsldsq swsmtqaqlt ndnlqntmit inalkqtnna 121 mkaqygkini dklqdmqdem ldlieqgdel qevlamnnns gelddisdae ldaeldalaq 181 edftlptsen slgndmpsyl lganappafi deepnldted knkalesaq // LOCUS NP_010775 208 aa linear PLN 30-JUN-2025 DEFINITION 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010775 VERSION NP_010775.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180795.1 REFERENCE 1 (residues 1 to 208) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 208) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 208) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 208) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12320. Method: conceptual translation. FEATURES Location/Qualifiers source 1..208 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..208 /product="3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3" /EC_number="4.1.99.12" /calculated_mol_wt="22437" Region 6..205 /region_name="DHBP_synthase" /note="3,4-dihydroxy-2-butanone 4-phosphate synthase; pfam00926" /db_xref="CDD:460001" CDS 1..208 /gene="RIB3" /locus_tag="YDR487C" /coded_by="NM_001180795.1:1..627" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:12595523]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12595523]" /experiment="EXISTENCE:mutant phenotype:GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity [PMID:7559556]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:12595523]" /experiment="EXISTENCE:mutant phenotype:GO:0009231 riboflavin biosynthetic process [PMID:5366000]" /note="3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase); required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration" /db_xref="GeneID:852098" /db_xref="SGD:S000002895" ORIGIN 1 mftpidqaie hfkqnkfviv mddagreneg dlicaaenvs teqmaflvrh ssgyvcapmt 61 naiadkldlp llrtgmkfes ndddrhgtay titvdvaqgt ttgisahdrs mtcraladss 121 stpksflkpg hicplraadg gvlqrrghte agvdlcklsg lspvavigel vnddeqgtmm 181 rlndcqafgk khgiplisie elaqylkk // LOCUS NP_010776 533 aa linear PLN 30-JUN-2025 DEFINITION dynein intermediate chain [Saccharomyces cerevisiae S288C]. ACCESSION NP_010776 VERSION NP_010776.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180796.1 REFERENCE 1 (residues 1 to 533) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 533) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 533) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 533) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12321. Method: conceptual translation. FEATURES Location/Qualifiers source 1..533 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..533 /product="dynein intermediate chain" /calculated_mol_wt="59943" Region <371..>473 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" CDS 1..533 /gene="PAC11" /locus_tag="YDR488C" /coded_by="NM_001180796.1:1..1602" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:21633107|PMID:15642746]" /experiment="EXISTENCE:genetic interaction:GO:0008574 plus-end-directed microtubule motor activity [PMID:23761070]" /experiment="EXISTENCE:genetic interaction:GO:0030473 nuclear migration along microtubule [PMID:9201714]" /experiment="EXISTENCE:mutant phenotype:GO:0008574 plus-end-directed microtubule motor activity [PMID:15642746]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:9201714|PMID:15642746]" /experiment="EXISTENCE:mutant phenotype:GO:0040001 establishment of mitotic spindle localization [PMID:21633107|PMID:23577064]" /experiment="EXISTENCE:physical interaction:GO:0005868 cytoplasmic dynein complex [PMID:9658168]" /note="Dynein intermediate chain, microtubule motor protein; required for intracellular transport and cell division; acts in cytoplasmic dynein pathway; forms complex with dynein light chain Dyn2p that promotes Dyn1p homodimerization and potentiates motor processivity; Dyn2p-Pac11p complex is also important for interaction of dynein motor complex with dynactin complex; forms cortical cytoplasmic microtubule capture site with Num1p; essential in the absence of CIN8" /db_xref="GeneID:852099" /db_xref="SGD:S000002896" ORIGIN 1 merlkqleek rrqlkelrer rkqaslfpgs etmghhptev hakatmvsvs vqtdmeegsk 61 iqepqsaylr rkevitydkg iqtdqieeeq lqenenhttt davaiettaa dennkdkaen 121 dqprlelakp flveeaaatl snasfarlet evsasgqqap snmqqdkdnl mqwnmvsenl 181 qsetdcdcia qeydpgkgvl vvvylrlppa dlqyasseaa wsvvnvvkcd nasgrnglli 241 dmvefrgtri mtatilrryh pesnvisill atltgkiily elrlkqkkpe tpvvyvvqrn 301 mvarhyfqhp vvavietssv qdqervlvaa dngnimelsc ldltvlrkpq qlrpvplsql 361 lslendtcty terlqrlakf devgiacmay tsedpqyvwi ggedggiykv fwdqpgplyl 421 sldnngfqpa enhstrvtgl efhwddarrl mlllscstdw tvrlwdarag kaiigaplll 481 ggpvlrarwl eknnggensr tlrcqvwcad grlvvvnwaf daktslytat vis // LOCUS NP_010777 294 aa linear PLN 30-JUN-2025 DEFINITION DNA replication protein SLD5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010777 VERSION NP_010777.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180797.3 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12322. On Jul 30, 2012 this sequence version replaced NP_010777.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..294 /product="DNA replication protein SLD5" /calculated_mol_wt="33817" Region 1..294 /region_name="COG5086" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227418" CDS 1..294 /gene="SLD5" /locus_tag="YDR489W" /gene_synonym="CDC105" /coded_by="NM_001180797.3:1..885" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:genetic interaction:GO:0031261 DNA replication preinitiation complex [PMID:12730134]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:12730134|PMID:12768207]" /experiment="EXISTENCE:mutant phenotype:GO:0031261 DNA replication preinitiation complex [PMID:12730134]" /experiment="EXISTENCE:physical interaction:GO:0000811 GINS complex [PMID:12730134|PMID:12768207]" /note="Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" /db_xref="GeneID:852100" /db_xref="SGD:S000002897" ORIGIN 1 mdiniddila eldkettavd stkitqgsss tthrdantiv gssldlndkt qiyvspqqdf 61 sdlmkswkne rcspellpyp hqlmkrllnr ismqsqlien ismgfldmqn asnanppmpn 121 esklpllcme telerlkfvi rsyircrlsk idkfslylrq lnedenslis ltdllskdei 181 kyhdthsliw lklvndsilk ympeelqain dtegsvnmid epdwnkfvfi hvngppdgkw 241 nedpllqene fgkpcytvti pdlkeevelt igsiyvmrye virdllrddk vali // LOCUS NP_010778 766 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase PKH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010778 VERSION NP_010778.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180798.3 REFERENCE 1 (residues 1 to 766) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 766) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 766) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 766) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12323. On Jul 30, 2012 this sequence version replaced NP_010778.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..766 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..766 /product="serine/threonine protein kinase PKH1" /EC_number="2.7.11.1" /calculated_mol_wt="86122" Region 123..391 /region_name="STKc_PDK1" /note="Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; cd05581" /db_xref="CDD:270733" Site order(131..135,139,152,154,187,203..204,206,210,212,249, 251,253..254,256,266..267,270,297..302,329,335,338) /site_type="active" /db_xref="CDD:270733" Site order(131..134,137,139,152,154,173,187,203..206,209..210, 253..254,256,266..267) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270733" Site order(135,210,212,249,251,253,270,297..302,329,335,338) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270733" Site order(266..276,294..302) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270733" CDS 1..766 /gene="PKH1" /locus_tag="YDR490C" /coded_by="NM_001180798.3:1..2301" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:22918958|PMID:10074427]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12221112]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:12221112]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:10567559]" /experiment="EXISTENCE:genetic interaction:GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly [PMID:21163942]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:22918958]" /experiment="EXISTENCE:genetic interaction:GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening [PMID:21163942]" /experiment="EXISTENCE:mutant phenotype:GO:0000196 cell integrity MAPK cascade [PMID:10567559]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11807089]" /note="Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ypk2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh2p; PKH1 has a paralog, PKH2, that arose from the whole genome duplication" /db_xref="GeneID:852101" /db_xref="SGD:S000002898" ORIGIN 1 mgnrsltead hallskplvp tsaehtqtqe yprpfvdgsn sqsgselqas pqgqfgekal 61 tstnrfipla nddpgmqhem gldpsmrrrr eewaergaak ivkdvvdpat geltkhvvkm 121 gikdfkfgeq lgdgsyssvv latardsgkk yavkvlskey lirqkkvkyv tveklalqkl 181 ngtkgifklf ftfqdeasly flleyaphgd flglikkygs lnetcaryya sqiidavdsl 241 hnigiihrdi kpenilldkn mkvkltdfgt akilpeepsn tadgkpyfdl yaksksfvgt 301 aeyvspelln dnytdsrcdi wafgcilyqm lagkppfkaa neyltfqkvm kiqyaftagf 361 pqivkdlvkk llvrdpndrl tikqikahlf fhevnfedgs vwddnppeiq pykinaeamk 421 plqkvsesdt tvkmanlqla gnghadtplq apaatsqehs vismtaataa fnkdytsqpk 481 lgsksstsvr sasnntdrev iqkkvsknra svsspsistt srgkdnrsrs sdafwsrylq 541 nmdervllmk evalstrnle dspvglenva ldyknpldie pptdsagkfy kkmflitnlg 601 ralvfvkrrs lsmweeqefe lqfelelndv ekirfisdqv leidgsrtif igckeravlm 661 klwklihngm takpkvvspk sdhkmfdkfi lqkrqntkkk nqappvpqsn rlinglpdrc 721 ilktpeegal htkrptslqt rsssnyskll arstqmrknm trtdek // LOCUS NP_010780 316 aa linear PLN 30-JUN-2025 DEFINITION PAQR-type receptor [Saccharomyces cerevisiae S288C]. ACCESSION NP_010780 VERSION NP_010780.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180800.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12324. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..316 /product="PAQR-type receptor" /calculated_mol_wt="36361" Region 75..300 /region_name="HlyIII" /note="Haemolysin-III related; pfam03006" /db_xref="CDD:427098" CDS 1..316 /gene="IZH1" /locus_tag="YDR492W" /coded_by="NM_001180800.1:1..951" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:15060275]" /note="Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc; IZH1 has a paralog, IZH4, that arose from the whole genome duplication" /db_xref="GeneID:852102" /db_xref="SGD:S000002900" ORIGIN 1 msitttrrrn qdsvcckatr asikveavsg qtvfekqkll hnfdelpewq kdndkiltgy 61 vretlswkkc lyslfywnne tvniythlvp aivyfvfait ltnyflipvf pstswsdytv 121 iniflmgafs clmcsscfhc mkqhsekqsn fwskldylgi isliscsmip iiyfgyfdhi 181 syfslftivt lvlatfctvc vlhdkfntst frpframffi lfgfsgllpl ttgffkfgiq 241 gvlnrikvsf vfwealfyis gaviygfrip etlapgkfdf fgsshqifhi mvvlgsvchl 301 kaiidsyklm hshihp // LOCUS NP_010781 123 aa linear PLN 30-JUN-2025 DEFINITION Mzm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010781 VERSION NP_010781.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180801.1 REFERENCE 1 (residues 1 to 123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 123) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12325. Method: conceptual translation. FEATURES Location/Qualifiers source 1..123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..123 /product="Mzm1p" /calculated_mol_wt="13796" Region 7..75 /region_name="Complex1_LYR_LYRM7" /note="LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins; cd20267" /db_xref="CDD:380762" CDS 1..123 /gene="MZM1" /locus_tag="YDR493W" /gene_synonym="AIM8; FMP36" /coded_by="NM_001180801.1:1..372" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:24769239|PMID:17054397|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:20404342]" /experiment="EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:21807901]" /experiment="EXISTENCE:mutant phenotype:GO:0044183 protein folding chaperone [PMID:22927643]" /experiment="EXISTENCE:physical interaction:GO:0044183 protein folding chaperone [PMID:22927643]" /note="Protein required for assembly of the cytochrome bc(1) complex; acts as a chaperone for Rip1p and facilitates its insertion into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochondrial zinc levels, which is characteristic of mutations affecting bc(1) complex assembly; member of the LYR protein family; human LYRM7 is a functional ortholog" /db_xref="GeneID:852104" /db_xref="SGD:S000002901" ORIGIN 1 mstrtkalna yrhglratri afrndaevll aarakmrsgm lcppdpkltt edqiqhledv 61 avflrrnlvq gkkvdgsstk epryhlnihk dtelgdneti adptarvktn lkarpfkcsd 121 kkq // LOCUS NP_010782 361 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS46 RSM28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010782 VERSION NP_010782.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180802.3 REFERENCE 1 (residues 1 to 361) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 361) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 361) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 361) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12326. On Jul 30, 2012 this sequence version replaced NP_010782.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..361 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..361 /product="mitochondrial 37S ribosomal protein mS46 RSM28" /calculated_mol_wt="41085" CDS 1..361 /gene="RSM28" /locus_tag="YDR494W" /gene_synonym="mS46" /coded_by="NM_001180802.3:1..1086" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:15701796]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:15701796]" /experiment="EXISTENCE:genetic interaction:GO:0070124 mitochondrial translational initiation [PMID:17194786]" /note="Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation" /db_xref="GeneID:852105" /db_xref="SGD:S000002902" ORIGIN 1 mrssmfrcvs rahystsvte dfinsilara qeatakassn alkldkmkeg rmqnkrrngn 61 qnrnsmnnke srgregnqge rnmrlknrss dsvrankqqw nkgantsfvk nptgntvvmq 121 pqfkkmqngk nnlkgdarve ddlldvfnss meqkpvnfng tpkskarfqk kshiltaskr 181 rkapqqqlqk vikrpvssey vleeptplsl leytpqvfpt kesrlvnftl dslkksnypi 241 yrspnlgilk vhdftlntpn fgkytpgssl ifakepqlqn llieedpedf hrqvtgeyql 301 lkpyvkkdfe kltkskdtvs klvqnsqvvr lslqsvvmgs eekklvydvc sgmkpiselq 361 q // LOCUS NP_010783 1011 aa linear PLN 30-JUN-2025 DEFINITION CORVET complex subunit VPS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010783 VERSION NP_010783.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180803.3 REFERENCE 1 (residues 1 to 1011) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1011) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1011) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1011) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1011) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1011) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1011) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1011) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1011) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12327. On Jul 30, 2012 this sequence version replaced NP_010783.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1011 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1011 /product="CORVET complex subunit VPS3" /calculated_mol_wt="116792" CDS 1..1011 /gene="VPS3" /locus_tag="YDR495C" /gene_synonym="PEP6; VPL3; VPT17" /coded_by="NM_001180803.3:1..3036" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:23417307]" /experiment="EXISTENCE:direct assay:GO:0033263 CORVET complex [PMID:17488625]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:2202738]" /experiment="EXISTENCE:mutant phenotype:GO:0007009 plasma membrane organization [PMID:39002672]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:2202738]" /note="Component of CORVET membrane tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase" /db_xref="GeneID:852106" /db_xref="SGD:S000002903" ORIGIN 1 mvkkktnndk gkevkenegk ldidsessph erendkkkte ddslratese etnthnanpn 61 etvradkfsq eesrpiedsp htdkntaqes cqpssaednv intditslne ktstndeqek 121 glplkisegp ftistlldnv psdliytcce ayenhiflgt ttgdllhyfe lergnymlvs 181 qtkfdaesns kidkilllpk vegalilcdn elvlfilpef aprpnttrlk gisdvvicnf 241 srsskayriy afhaegvrll kisadslvlt kafnfklidk acaheetlmv sklnsyelin 301 lkssqviplf risetdedle piitsfneqs eflvcsgggs ydsgamalvv nhhgdiikgt 361 ivlknyprnv ivefpyiiae safqsvdiys alpseksqll qsittsgsdl kisksdnvft 421 ntnnseefke kifnklrlep lthsdnkfri ererafvees yeektslivy nnlgihllvp 481 tpmvlrftsc eeseidnied qlkklakkdl tkfehieaky lmslllflmt lhydhiedev 541 mkkwcdfsdk vdirilfymf gwkvyseiwc fhgliniver lkslkltnkc enilkmllmm 601 knelkkknkt glltndfddi mktiditlfk lrlekketit vdmferesyd eiireinlhd 661 dklprielli eiykekgeyl kalnllreag dyislvsfie enlkklpedy ikeriaddll 721 ltlkqgdent eecaikkvlk ildmacinkn dflnkipaee tslkvsfieq lgvqnsndsk 781 flfnyylakl reiinqsniw silgdfikey kddfaydktd itnfihiklk hslqcenfsk 841 yyekcenlks enekddefin ftfdeiskid kehiltllff pneltnwvss eellkiylsf 901 ndfrsvekyi gkqnlvavmk qyldisslny svelvtnllq rnfellddtd iqlkiletip 961 svfpvqtise lllkvlikyq ekkeesnlrk cllknqisis delsrnfdsq g // LOCUS NP_010784 656 aa linear PLN 30-JUN-2025 DEFINITION Puf6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010784 VERSION NP_010784.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180804.1 REFERENCE 1 (residues 1 to 656) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 656) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 656) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 656) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12328. Method: conceptual translation. FEATURES Location/Qualifiers source 1..656 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..656 /product="Puf6p" /calculated_mol_wt="74975" Region 173..431 /region_name="Pumilio" /note="Pumilio-family RNA binding domain; cl46378" /db_xref="CDD:480718" Region 425..567 /region_name="CPL" /note="CPL (NUC119) domain; pfam08144" /db_xref="CDD:462370" CDS 1..656 /gene="PUF6" /locus_tag="YDR496C" /coded_by="NM_001180804.1:1..1971" /experiment="EXISTENCE:direct assay:GO:0000900 mRNA regulatory element binding translation repressor activity [PMID:15198983]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003730 mRNA 3'-UTR binding [PMID:15198983]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0015934 large ribosomal subunit [PMID:19806183]" /experiment="EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:15198983]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:27458021]" /experiment="EXISTENCE:direct assay:GO:0048027 mRNA 5'-UTR binding [PMID:31323064]" /experiment="EXISTENCE:direct assay:GO:0070180 large ribosomal subunit rRNA binding [PMID:34349113]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:31779129|PMID:19806183|PMID:27458021]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:31779129]" /experiment="EXISTENCE:mutant phenotype:GO:0101031 protein folding chaperone complex [PMID:31779129]" /note="Pumilio-homology domain protein; binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; required at post-transcriptional step for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; co-sediments with the 60S ribosomal subunit and is required for its biogenesis" /db_xref="GeneID:852107" /db_xref="SGD:S000002904" ORIGIN 1 mapltkktng krsakevshs ekklakkpri sidssdeese lskkedavss ssddddlddl 61 stsdseaeee adeldisdds eeheneneek egkdksegge ngnhteqrkl lkerkmqrks 121 gtqvqqiksv werlrvktpp lpkqirekls neiwelskdc isdlvlkhda srivqtlvky 181 sskdrreqiv dalkgkfyvl atsaygkyll vkllhygsrs srqtiinelh gslrklmrhr 241 egayvvedlf vlyatheqrq qmikefwgse yavfrethkd ltiekvcess iekrniiarn 301 ligtitasve kgstgfqilh aamreyvkia nekeisemie llheqfaelv htpegsdvac 361 tlvaranake rklilkalkn haeklikney gnivfitiln cvddtvlvfk tfsptvkehl 421 qefiidkfgr rpwlyillgl dgkyfspivk nellryiels katskkdplq rrhellskfa 481 pmflstiskd yssiltenlg cqfiaevlin delyaqlnek dqekyqqvln nilttfkgdi 541 teeehpihra fstrllkali qggkwnnkek kviplknvqg lgvpfaekly deiidssnll 601 ewinnadssf tivalyetlk dqkegkpflk dlrgvqskit tdesnkgsql lakllk // LOCUS NP_010785 584 aa linear PLN 30-JUN-2025 DEFINITION myo-inositol transporter ITR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010785 VERSION NP_010785.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180805.1 REFERENCE 1 (residues 1 to 584) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 584) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 584) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 584) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12329. Method: conceptual translation. FEATURES Location/Qualifiers source 1..584 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..584 /product="myo-inositol transporter ITR1" /calculated_mol_wt="63439" Region 92..533 /region_name="MFS_HMIT_like" /note="H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; cd17360" /db_xref="CDD:340918" Site order(100,104,221,224..225,228,348..349,353..354,357..358, 383,458..459,462..463,467,489..490,493) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340918" CDS 1..584 /gene="ITR1" /locus_tag="YDR497C" /coded_by="NM_001180805.1:1..1755" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922|PMID:16233524]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005365 myo-inositol transmembrane transporter activity [PMID:2040626]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:24603354]" /experiment="EXISTENCE:mutant phenotype:GO:0015798 myo-inositol transport [PMID:2040626]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:2040626]" /note="Myo-inositol transporter; member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress; ITR1 has a paralog, ITR2, that arose from the whole genome duplication" /db_xref="GeneID:852108" /db_xref="SGD:S000002905" ORIGIN 1 mgihipylts ktsqsnvgda vgnadsvefn sehdspskrg kitlesheiq rapasddedr 61 iqikpvnded dtsvmitfnq slspfiitlt fvasisgfmf gydtgyissa lisigtdldh 121 kvltygekei vtaatslgal itsifagtaa difgrkrclm gsnlmfviga ilqvsahtfw 181 qmavgrlimg fgvgigslia plfiseiapk mirgrltvin slwltggqlv aygcgaglny 241 vnngwrilvg lsliptavqf tclcflpdtp ryyvmkgdla ratevlkrsy tdtseeiier 301 kveelvtlnq sipgknvpek vwntikelht vpsnlralii gcglqaiqqf tgwnslmyfs 361 gtifetvgfk nssavsiivs gtnfiftlva ffsidkigrr tilliglpgm tmalvvcsia 421 fhflgikfdg avavvvssgf sswgiviivf iivfaafyal gigtvpwqqs elfpqnvrgi 481 gtsyatatnw agslviastf ltmlqnitpa gtfaffagls clstifcyfc ypelsglele 541 evqtilkdgf nikaskalak krkqqvarvh elkyeptqei iedi // LOCUS NP_010786 383 aa linear PLN 30-JUN-2025 DEFINITION Sec20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010786 VERSION NP_010786.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180806.3 REFERENCE 1 (residues 1 to 383) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 383) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 383) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 383) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12330. On Jul 30, 2012 this sequence version replaced NP_010786.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..383 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..383 /product="Sec20p" /calculated_mol_wt="43751" Region 204..295 /region_name="Sec20" /note="pfam03908" /db_xref="CDD:112708" CDS 1..383 /gene="SEC20" /locus_tag="YDR498C" /coded_by="NM_001180806.3:1..1152" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8334998|PMID:26928762|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:1537327]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9214619|PMID:12853481|PMID:12893879]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8612273]" /note="Membrane glycoprotein v-SNARE; involved in retrograde transport from the Golgi to the endoplasmic reticulum (ER); required for N- and O-glycosylation in the Golgi but not in the ER and for efficient nuclear fusion during mating; mediates Sey1p-independent homotypic ER fusion; interacts with the Dsl1p complex through Tip20p" /db_xref="GeneID:852109" /db_xref="SGD:S000002906" ORIGIN 1 mvvtflqdle vlqdallnnl qklsaisrrk esgeskhdnk dsfaaianeh ndeeeeiefe 61 dlvniieskv sdfesvlkcs ivemtykype lklqwekspr ydqcdklhiv kldkqmnedi 121 yaqlveeldf vlqfvdwfyc yrlkvkeilr qhhkrdlawn dekrdraikf havdydklhq 181 gtssssslts tsmekastre kllsktkqlt nnlvrgnqil qsgilqsdln ldelraqtns 241 ltqiddkytq fetvfkktad lvkvlenash qekrdvylsl gfllccvswv lwrrifklpv 301 klglwllfkf fkgilvtlgl vksyagssss lqapslvlna pilattttss atsvepfasv 361 savssiqrav deavdrivsh del // LOCUS NP_010787 747 aa linear PLN 30-JUN-2025 DEFINITION Lcd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010787 VERSION NP_010787.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180807.3 REFERENCE 1 (residues 1 to 747) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 747) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 747) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 747) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12331. On Jul 30, 2012 this sequence version replaced NP_010787.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..747 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..747 /product="Lcd1p" /calculated_mol_wt="86294" Region 77..745 /region_name="LCD1" /note="DNA damage checkpoint protein; pfam09798" /db_xref="CDD:462906" CDS 1..747 /gene="LCD1" /locus_tag="YDR499W" /gene_synonym="DDC2; PIE1" /coded_by="NM_001180807.3:1..2244" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11983176]" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:11983176]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0045184 establishment of protein localization [PMID:11983176]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:11060031]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:12181334]" /experiment="EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:11983176]" /note="Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p and contributes to its activation; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:852110" /db_xref="SGD:S000002907" ORIGIN 1 mrretvgefs sdddddille lgtrpprftq ippssaalqt qipttlevtt ttlnnkqskn 61 dnqlvnqlnk aqgeasmlrd kinflniere kekniqavkv nelqvkhlqe laklkqelqk 121 ledekkflqm eargkskrev itnvkppstt lstntntitp dsssvaieak pqspqskkrk 181 isdnllkknm vplnpnriip detslflesi llhqiigadl stieilnrlk ldyitefkfk 241 nfviakgapi gksivslllr ckktltldrf idtllediav likeisvhpn esklavpflv 301 almyqivqfr psathnlalk dcflficdli riyhhvlkvp ihesnmnlhv epqifqyeli 361 dyliisysfd llegilrvlq shpkqtymef fdenilksfe fvyklaltis ykpmvnvifs 421 avevvniits iilnmdnssd lkslisgsww rdcitrlyal lekeiksgdv ynenvdtttl 481 hmskyhdffg lirnigdnel ggliskliyt drlqsvprvi skedigmdsd kftapiigyk 541 mekwllklkd evlnifenll miygddativ ngemlihssk flsreqalmi eryvgqdspn 601 ldlrchlieh tltiiyrlwk dhfkqlreeq ikqvesqlim slwrflvcqt etvtanerem 661 rdhrhlvdsl hdltikdqas yyedafedlp eyieeelkmq lnkrtgrimq vkydekfqem 721 artilesksf dlttleeads lyismgl // LOCUS NP_010788 88 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL37 RPL37B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010788 VERSION NP_010788.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180808.1 REFERENCE 1 (residues 1 to 88) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 88) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 88) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 88) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12332. Method: conceptual translation. FEATURES Location/Qualifiers source 1..88 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..88 /product="60S ribosomal protein eL37 RPL37B" /calculated_mol_wt="9737" Region 1..83 /region_name="PTZ00073" /note="60S ribosomal protein L37; Provisional" /db_xref="CDD:240257" CDS 1..88 /gene="RPL37B" /locus_tag="YDR500C" /coded_by="NM_001180808.1:1..267" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23268442]" /experiment="EXISTENCE:genetic interaction:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23268442]" /note="Ribosomal 60S subunit protein L37B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication" /db_xref="GeneID:852111" /db_xref="SGD:S000002908" ORIGIN 1 mgkgtpsfgk rhnkshtlcn rcgrrsfhvq kktcsscgyp saktrshnwa akakrrhttg 61 tgrmrylkhv srrfkngfqt gsakatsa // LOCUS NP_010789 521 aa linear PLN 30-JUN-2025 DEFINITION Plm2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010789 VERSION NP_010789.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180809.1 REFERENCE 1 (residues 1 to 521) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 521) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 521) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 521) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12333. Method: conceptual translation. FEATURES Location/Qualifiers source 1..521 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..521 /product="Plm2p" /calculated_mol_wt="58071" Region 80..220 /region_name="FHA_PLM2-like" /note="forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein 2 (PLM2) and similar proteins; cd22699" /db_xref="CDD:438751" Site order(105..106,122..123,125,143,145..146) /site_type="other" /note="putative phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438751" CDS 1..521 /gene="PLM2" /locus_tag="YDR501W" /coded_by="NM_001180809.1:1..1566" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12464632]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:12760057]" /note="Putative transcription factor, contains Forkhead Associated domain; found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; PLM2 has a paralog, TOS4, that arose from the whole genome duplication" /db_xref="GeneID:852112" /db_xref="SGD:S000002909" ORIGIN 1 mshlfppssp vagkplespq kepgklants vltlgrkryn yeleeyptpd psssigrqss 61 pvkditsrln etksalssps kqekvlagpi eieldasdps rlaigrkksv cniilpcrkn 121 isrqhafisy aadrneikle cngtnglsvh lpysmqlhlv kpfptrnfyk lvaeepltsq 181 ntkqshgktl qknqnfisfv lakgetvtfp yiqgsfinft gvtvclslkk vapypgdgnn 241 nfdeenstet edelcllttt sddfswqket psmkfvpveh sprteqiskp lliaspalvk 301 nspisyrttp qtsfvinqps tpkklkrksi slknntiqet plpkdkiigt lsastrsggi 361 neeesfaava kktkelsstt aivspaqkrl ktslniipei srslsergir fddlvhvlcn 421 hlafsnlqqt plsqlqnins ntsqlskdel kkvletisci giivregkda sgkpledeyy 481 ydvenddsde rkilynslkg rsrlrscrkk hkqyfwkrpt k // LOCUS NP_010790 384 aa linear PLN 30-JUN-2025 DEFINITION methionine adenosyltransferase SAM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010790 VERSION NP_010790.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180810.3 REFERENCE 1 (residues 1 to 384) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 384) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 384) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 384) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12334. On Jul 30, 2012 this sequence version replaced NP_010790.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..384 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..384 /product="methionine adenosyltransferase SAM2" /EC_number="2.5.1.6" /calculated_mol_wt="42125" Region 8..380 /region_name="S-AdoMet_synt" /note="S-adenosylmethionine synthetase; cd18079" /db_xref="CDD:350837" Site order(8..10,12,46,48,50,55,57..59,123..126,128,170,172,174, 191,193,232,235,246..248,250..253,256,261..268,270,274,306, 308..312,317..318,320) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:350837" Site order(12,18..20,44,59,102,105..106,122..123,168,170,195, 236,238..239,241,247,253..254,268..270,274,278,280,311) /site_type="active" /db_xref="CDD:350837" Site order(12,18..19,168,170,254) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350837" CDS 1..384 /gene="SAM2" /locus_tag="YDR502C" /gene_synonym="ETH2" /coded_by="NM_001180810.3:1..1155" /experiment="EXISTENCE:direct assay:GO:0004478 methionine adenosyltransferase activity [PMID:18078345]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0006555 methionine metabolic process [PMID:4585174]" /experiment="EXISTENCE:mutant phenotype:GO:0006556 S-adenosylmethionine biosynthetic process [PMID:17426150]" /note="S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon" /db_xref="GeneID:852113" /db_xref="SGD:S000002910" ORIGIN 1 msksktflft sesvgeghpd kicdqvsdai ldacleqdpf skvacetaak tgmimvfgei 61 ttkarldyqq ivrdtikkig yddsakgfdy ktcnvlvaie qqspdiaqgl hyeksledlg 121 agdqgimfgy atdetpeglp ltillahkln mamadarrdg slpwlrpdtk tqvtveyedd 181 ngrwvpkrid tvvisaqhad eistadlrtq lqkdivekvi pkdmldentk yfiqpsgrfv 241 iggpqgdagl tgrkiivday ggassvggga fsgkdyskvd rsaayaarwv akslvaaglc 301 krvqvqfsya igiaeplslh vdtygtatks ddeiieiikk nfdlrpgvlv keldlarpiy 361 lptasyghft nqeyswekpk klef // LOCUS NP_010791 274 aa linear PLN 30-JUN-2025 DEFINITION phosphatidate phosphatase LPP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010791 VERSION NP_010791.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180811.3 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12335. On Jul 30, 2012 this sequence version replaced NP_010791.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..274 /product="phosphatidate phosphatase LPP1" /EC_number="3.1.3.4" /EC_number="3.1.3.106" /EC_number="3.6.1.75" /calculated_mol_wt="31455" Region 52..258 /region_name="PAP2_containing_1_like" /note="PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both...; cd03390" /db_xref="CDD:239484" Site order(136,143,187..189,229,235,239) /site_type="active" /db_xref="CDD:239484" CDS 1..274 /gene="LPP1" /locus_tag="YDR503C" /coded_by="NM_001180811.3:1..825" /experiment="EXISTENCE:direct assay:GO:0008195 phosphatidate phosphatase activity [PMID:10685032]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:10685032]" /experiment="EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:10329682]" /note="Lipid phosphate phosphatase; catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA" /db_xref="GeneID:852114" /db_xref="SGD:S000002911" ORIGIN 1 misvmadekh keyfklyyfq ymiiglctil flyseislvp rgqniefsld dpsiskryvp 61 nelvgplecl ilsvglsnmv vfwtcmfdkd llkknrvkrl rerpdgisnd fhfmhtsilc 121 lmliisinaa ltgalkliig nlrpdfvdrc ipdlqkmsds dslvfgldic kqtnkwilye 181 glkstpsghs sfivstmgft ylwqrvfttr ntrsciwcpl lalvvmvsrv idhrhhwydv 241 vsgavlaflv iyccwkwtft nlakrdilps pvsv // LOCUS NP_010792 127 aa linear PLN 30-JUN-2025 DEFINITION Spg3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010792 VERSION NP_010792.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180812.1 REFERENCE 1 (residues 1 to 127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 127) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12336. Method: conceptual translation. FEATURES Location/Qualifiers source 1..127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..127 /product="Spg3p" /calculated_mol_wt="15449" CDS 1..127 /gene="SPG3" /locus_tag="YDR504C" /coded_by="NM_001180812.1:1..384" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum" /db_xref="GeneID:852115" /db_xref="SGD:S000002912" ORIGIN 1 micyflvvti nflkekttic hyfvnifslf lflfvfvfvf ifvyffyvil fyrfcslfty 61 fpansiwyyl siiniffplc fflyenftgr nrrkcslfcl tlikitytsp nhgfmvtgke 121 kfeklrd // LOCUS NP_010793 841 aa linear PLN 30-JUN-2025 DEFINITION Psp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010793 VERSION NP_010793.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180813.2 REFERENCE 1 (residues 1 to 841) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 841) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 841) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 841) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 841) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 841) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 841) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 841) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 841) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12337. On Apr 26, 2011 this sequence version replaced NP_010793.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..841 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..841 /product="Psp1p" /calculated_mol_wt="95217" Region 653..765 /region_name="PSP1" /note="PSP1 C-terminal conserved region; pfam04468" /db_xref="CDD:461321" CDS 1..841 /gene="PSP1" /locus_tag="YDR505C" /gene_synonym="GIN5" /coded_by="NM_001180813.2:1..2526" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="Asn and gln rich hypothetical protein; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; capable of forming the prion [PSP1+]; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication" /db_xref="GeneID:852116" /db_xref="SGD:S000002913" ORIGIN 1 mdlptvnstt sisdnvdlkn yyedllfknn sgkslsdlpr klndnsnnsg sdtvdplagl 61 nnlrnsiksa gngmenrrtf ddidfmgrfp ylppvpnqqq qpfshqngfi qehpssnlts 121 fqmsssnsep msappissnn nnlnstqmgn yqaqqrsfpq fngnsfhsng ndlmgnrmds 181 dymrlmnktn igftsnsgsn faapshsagn pssmnnqqvp sfnwqqpshp estirrssyi 241 sdtlinhqmp darqkqtsqv qqqhaqgfnl fnsrfnydnl nsthltakgv pefgngvqpp 301 ypydnepnna sisnsnnnnn shnmvpmqqf rrntqpvasf npslptfqqq qqqpqqpqqp 361 rnvnvptsfn gervddvqlv qlqrsssvps stnshnlqne nsnegnvsld nglvliqgkh 421 ltssktlhdl ysdcgsgyfa ssavfeftdn ikkmlklhds nesydaknmg lideegntyq 481 sllnfldilr scnmnyvndp esnngivsnn ggnknrrkgs fttelscrna nnsflpytpl 541 vlvalkngkl ellstpqatn lllkrgdlvi idgdrgrdlv lvvepsvdln lalfinflkk 601 kihfdslits esqhyrndef iqmlidskng qkkklnpkly dvveltelii pskqvlrfat 661 pwevttnlhn kfedelkalh iaqsklqaln dnsksqntnd sssnnftnaa tyskpklnik 721 ilnaefqfdr kkltfyyvce erndfrdlik elfkyyktri wlcaipnnls idskyydkqq 781 kelklyqniv knynaedlmn vnefsqnrgn nrvnfappln eieldnfqia vyeelvhelf 841 h // LOCUS NP_010794 608 aa linear PLN 30-JUN-2025 DEFINITION putative oxidoreductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010794 VERSION NP_010794.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180814.3 REFERENCE 1 (residues 1 to 608) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 608) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 608) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 608) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12338. On Jul 30, 2012 this sequence version replaced NP_010794.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..608 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..608 /product="putative oxidoreductase" /calculated_mol_wt="69150" Region 29..164 /region_name="CuRO_1_MCO_like_2" /note="The second cupredoxin domain of uncharacterized multicopper oxidase; cd13864" /db_xref="CDD:259932" Site order(33,37..38,58,63,96,102,138..143,145,152..154, 157..159,161) /site_type="other" /note="putative Domain 2 interface [polypeptide binding]" /db_xref="CDD:259932" Site order(100,102,105,128..129,145,147,149,152..153) /site_type="other" /note="putative Domain 3 interface [polypeptide binding]" /db_xref="CDD:259932" Region 206..345 /region_name="CuRO_2_Fet3p_like" /note="The second Cupredoxin domain of multicopper oxidase Fet3P; cd13877" /db_xref="CDD:259945" Site order(208..211,215,241,244..247,253,264,266,268,291..293, 308,310,339,341..342) /site_type="other" /note="Domain 1 interface [polypeptide binding]" /db_xref="CDD:259945" Site order(273,275,287..288,290..294,296..298,300,304,306..311) /site_type="other" /note="Domain 3 interface [polypeptide binding]" /db_xref="CDD:259945" Region <435..547 /region_name="Cupredoxin" /note="Cupredoxin superfamily; cl19115" /db_xref="CDD:473140" CDS 1..608 /gene="GMC1" /locus_tag="YDR506C" /coded_by="NM_001180814.3:1..1827" /experiment="EXISTENCE:genetic interaction:GO:0051321 meiotic cell cycle [PMID:22194413]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:22194413]" /experiment="EXISTENCE:mutant phenotype:GO:0070193 synaptonemal complex organization [PMID:22194413]" /note="Protein involved in meiotic progression; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; possible membrane-localized protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /db_xref="GeneID:852117" /db_xref="SGD:S000002914" ORIGIN 1 mkvillkpvq lpmlllillk fimaakegki hvlefnasse ytldkrrvis ingysatfgp 61 eirvksgdtl nlkltnwics eeeaskdsdv wkdycstalh fhgvvplane fdgipgltqp 121 tigygesywy nftidqstcg tfwyhshssv qygdgmrgvl ivecddydnh vantinsvrd 181 ietlddgvvt mkkdkhtkel tdyevqerii tlsdwytnwn ldilndkvls stggtdpkfd 241 gslingkssd getikigfnt eylllrivns gmsgtqvfhl dgfqlivlea dgimikpfiv 301 qtinlavgqr ytilvklksd tsfirmingc nkmmgyitkq wwfykegahl dlpknpndvs 361 iehlpgftka elyrdieptq eenkklrtka dpvavfefdy ayykdestkq kygtgmykvn 421 ertfseyvkd pvrfgfnety divinsldhm rhpwhmhghh fqiislgnkg dgpfhkdvqe 481 gkawsryqnd lrhlartgka pmvrdsinia gnsyavlrin tempgkwllh chvewhmmkg 541 lgivfevptt tedstkqatt avlsyptkep dpntvvhtaa leqnkskvia vyilimcavd 601 aifywllm // LOCUS NP_010795 1142 aa linear PLN 30-JUN-2025 DEFINITION protein kinase GIN4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010795 VERSION NP_010795.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180815.3 REFERENCE 1 (residues 1 to 1142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1142) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12339. On Jul 30, 2012 this sequence version replaced NP_010795.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1142 /product="protein kinase GIN4" /EC_number="2.7.11.1" /calculated_mol_wt="129728" Region 17..289 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(25..28,31,33,46,48,94,110..113,156,160..161,163, 173..174) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270983" Region 1026..1139 /region_name="Kcc4p_like_C" /note="C-terminal kinase associated domain 1 (KA1), a phospholipid binding domain, of Kcc4p and similar proteins; cd12194" /db_xref="CDD:213379" Site order(1036,1065,1070,1084,1112,1115,1121,1125) /site_type="other" /note="putative phospholipid binding site [chemical binding]" /db_xref="CDD:213379" CDS 1..1142 /gene="GIN4" /locus_tag="YDR507C" /gene_synonym="ERC47" /coded_by="NM_001180815.3:1..3429" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9813093]" /experiment="EXISTENCE:genetic interaction:GO:0007117 budding cell bud growth [PMID:15107529]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:9813093]" /experiment="EXISTENCE:mutant phenotype:GO:0007117 budding cell bud growth [PMID:9925642]" /experiment="EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:9925642]" /experiment="EXISTENCE:mutant phenotype:GO:1901900 regulation of protein localization to cell division site [PMID:28148650]" /note="Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; negatively regulates Fpk1p kinase that stimulates phospholipid flippases Dnf1p and Dnf2p; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication" /db_xref="GeneID:852119" /db_xref="SGD:S000002915" ORIGIN 1 maingnsipa ikdntigpwk lgetlglgst gkvqlarngs tgqeaavkvi skavfntgnv 61 sgtsivgstt pdalpygier eiiimkllnh pnvlrlydvw etntdlylvl eyaekgelfn 121 llvergplpe heairffrqi iigvsychal givhrdlkpe nllldhkyni kiadfgmaal 181 etegkllets cgsphyaape ivsgipyqgf asdvwscgvi lfalltgrlp fdeedgnirt 241 lllkvqkgef empsddeisr eaqdlirkil tvdperrikt rdilkhpllq kypsirdsks 301 irglpredty ltplsesnss idatilqnlv ilwhgrdpeg ikeklrepga naektlyall 361 yrfkcdtqke likqqqvkkr qsissvsvsp skkvsttpqr rrnreslisv tssrkkpisf 421 nkftassass snlttpgssk rlsknfsskk klstivnqss ptpasrnkra svinveknqk 481 rasifsttkk nkrssrsikr mslipsmkre svttklmsty aklaedddwe yieketkrts 541 snfatlidei feyekyeqir kekeelerkv reakareele rrrrkqeeke rarklleked 601 lkrkqeelkk qieidisdle qelskhkeek ldgnirsisa pmeneeknin hlevdidnil 661 rrrnfslqtr pvsrldpgim fsspteevsp vepkrtener lttekkilet irrskflgss 721 fnidkelkls kmeypsiiap qrlseervvs dsndgyesli lpkdgngvsq lkdstattap 781 vsdgrlrkis eirvpqftrk srhfsesnkr lsvlsmystk esftnlvdil kngnldvnnq 841 qsqriptprs addseflfet vneeaeytgn ssnderlydv gdstikdksa lklnfadrfn 901 gsneakqtdn lhlpilppln gdnelrkqns qegdqahpki ksmipesgss shtekeeene 961 ekeekkpeqh kqeedqekre kvvddmeppl nksvqkirek nagsqakdhs kdhlkehkqd 1021 kntaigngsf frkfskssdk tmelyakisa kqlfnglekl lrgwtqyglk nikshpnnlt 1081 ltgklssdni fslrstlfev niyprgkmsv vqfkkvsgsf kavkklvnev envlnkegvl 1141 qk // LOCUS NP_010796 663 aa linear PLN 30-JUN-2025 DEFINITION glutamine permease GNP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010796 VERSION NP_010796.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180816.1 REFERENCE 1 (residues 1 to 663) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 663) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 663) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 663) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12340. Method: conceptual translation. FEATURES Location/Qualifiers source 1..663 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..663 /product="glutamine permease GNP1" /calculated_mol_wt="73467" Region 146..626 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..663 /gene="GNP1" /locus_tag="YDR508C" /coded_by="NM_001180816.1:1..1992" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006865 amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015171 amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015193 L-proline transmembrane transporter activity [PMID:14968425]" /experiment="EXISTENCE:genetic interaction:GO:0098718 serine import across plasma membrane [PMID:32845888]" /experiment="EXISTENCE:mutant phenotype:GO:0090156 intracellular sphingolipid homeostasis [PMID:32845888]" /experiment="EXISTENCE:mutant phenotype:GO:0098718 serine import across plasma membrane [PMID:32845888]" /note="Broad specificity amino acid permease; high-affinity glutamine permease; major serine permease with minor contributions from paralog Agp1p; role in serine uptake impacts cellular sphingolipid homeostasis; also transports Leu, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids" /db_xref="GeneID:852121" /db_xref="SGD:S000002916" ORIGIN 1 mtlgnrrhgr nnegssnmnm nrndlddvsh yemkeiqpke kqigsiepen eveyfektve 61 ktienmeyeg ehhasylrrf idsfrraegs hanspdssns ngttpistkd sssqldneln 121 rkssyitvdg ikqspqeqeq kqenlkksik prhtvmmslg tgigtgllvg nskvlnnagp 181 ggliigyaim gscvyciiqa cgelaviysd liggfntypl flvdpalgfs vawlfclqwl 241 cvcplelvta smtikywtts vnpdvfvvif yvlivvinvf gakgyaeadf ffncckilmi 301 vgffilaiii dcggagtdgy igskywrdpg afrgdtpiqr fkgvvatfvt aafafgmseq 361 lamtaseqsn prkaipsaak kmiyrilfvf lasltlvgfl vpytsdqllg aagsatkasp 421 yviavsshgv rvvphfinav illsvlsvan gafytssril mslakqgnap kcfdyidreg 481 rpaaamlvsa lfgviafcas skkeedvftw llaisglsql ftwiticlsh irfrramkvq 541 grslgevgyk sqvgvwgsay avlmmvlali aqfwvaiapi ggggklsaqs ffenylampi 601 wialyifykv wkkdwslfip adkvdlvshr nifdeellkq edeeykerlr ngpywkrvld 661 fwc // LOCUS NP_010798 101 aa linear PLN 30-JUN-2025 DEFINITION SUMO family protein SMT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010798 VERSION NP_010798.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180818.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12341. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..101 /product="SUMO family protein SMT3" /calculated_mol_wt="11466" Region 1..101 /region_name="SMT3" /note="Ubiquitin-like protein (sentrin) [Posttranslational modification, protein turnover, chaperones]; COG5227" /db_xref="CDD:227552" Site order(22..23,25,35..38,40,43,47..48,50..51,54..55) /site_type="other" /note="Smt3-Ysmb1 interaction site [polypeptide binding]" /db_xref="CDD:340533" Site order(27,29..31,67..70,82,84,86..88,90..92) /site_type="other" /note="Smt3-Ubc9 interaction site [polypeptide binding]" /db_xref="CDD:340533" Site order(29,46,61,66,68..69,71,74,88,90,92..94) /site_type="other" /note="SUMO-Xopd interaction site [polypeptide binding]" /db_xref="CDD:340533" Site order(29..31,67..69,82,84,86..88,90..92) /site_type="other" /note="RING E3/E2-SUMO complex [polypeptide binding]" /db_xref="CDD:340533" Site order(61,64,66..71,73,76,82,87,90,92..94) /site_type="other" /note="Smt3-Ulp1 interaction site [polypeptide binding]" /db_xref="CDD:340533" Site order(64,66..71,79..82) /site_type="other" /note="Smt3-PCNA interaction site [polypeptide binding]" /db_xref="CDD:340533" Site order(67..70,81..82,84) /site_type="other" /note="Smt3-FadD32 interaction site [polypeptide binding]" /db_xref="CDD:340533" CDS 1..101 /gene="SMT3" /locus_tag="YDR510W" /coded_by="NM_001180818.1:1..306" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16782016]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10579719|PMID:10364461]" /experiment="EXISTENCE:direct assay:GO:0005940 septin ring [PMID:10364461|PMID:10579719]" /experiment="EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:9312010]" /experiment="EXISTENCE:direct assay:GO:0031386 protein tag activity [PMID:10579719|PMID:10364461]" /note="Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; human homolog SUMO1 can complement yeast null mutant" /db_xref="GeneID:852122" /db_xref="SGD:S000002918" ORIGIN 1 msdsevnqea kpevkpevkp ethinlkvsd gsseiffkik kttplrrlme afakrqgkem 61 dslrflydgi riqadqtped ldmedndiie ahreqiggat y // LOCUS NP_010799 133 aa linear PLN 30-JUN-2025 DEFINITION Sdh7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010799 VERSION NP_010799.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180819.3 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12342. On Jul 30, 2012 this sequence version replaced NP_010799.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..133 /product="Sdh7p" /calculated_mol_wt="15652" Region 23..79 /region_name="Complex1_LYR_SDHAF3_LYRM10" /note="LYR (leucine-tyrosine-arginine) motif found in mitochondrial succinate dehydrogenase assembly factor 3 (SDHAF3) and similar proteins; cd20270" /db_xref="CDD:380765" CDS 1..133 /gene="SDH7" /locus_tag="YDR511W" /gene_synonym="ACN9" /coded_by="NM_001180819.3:1..402" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:24954417]" /experiment="EXISTENCE:mutant phenotype:GO:0006111 regulation of gluconeogenesis [PMID:8878673]" /experiment="EXISTENCE:mutant phenotype:GO:0015976 carbon utilization [PMID:8878673]" /experiment="EXISTENCE:physical interaction:GO:0034553 mitochondrial respiratory chain complex II assembly [PMID:24954417]" /note="Mitochondrial protein involved in assembly of succinate dehydrogenase; has a role in maturation of the Sdh2p subunit; localized to the mitochondrial intermembrane space; required for acetate utilization and gluconeogenesis; mutation in Drosophila ortholog SDHAF3 causes reduced succinate dehydrogenase activity and neuronal and muscular dysfunction; member of the LYR protein family" /db_xref="GeneID:852123" /db_xref="SGD:S000002919" ORIGIN 1 mnnkliyrsv rfathnsqll lpplvlyrri lrqhkllpgp qremgdqyvr nefklhkdid 61 nplhivgfla swqdylhmis ngkwkdatls setleklspe qtvqlyelmk etqklhqdne 121 iesskdvkrn nkd // LOCUS NP_010800 187 aa linear PLN 30-JUN-2025 DEFINITION Emi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010800 VERSION NP_010800.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180820.3 REFERENCE 1 (residues 1 to 187) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 187) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 187) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 187) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12343. On Jul 30, 2012 this sequence version replaced NP_010800.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..187 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..187 /product="Emi1p" /calculated_mol_wt="20940" Region 104..181 /region_name="DUF3128" /note="Protein of unknown function (DUF3128); pfam11326" /db_xref="CDD:463261" CDS 1..187 /gene="EMI1" /locus_tag="YDR512C" /coded_by="NM_001180820.3:1..564" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:19703468]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:12586695]" /note="Non-essential hypothetical protein; required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs; deletion affects mitochondrial morphology" /db_xref="GeneID:852125" /db_xref="SGD:S000002920" ORIGIN 1 miitikfesk eklvsmkqyi tvvgvsvnqe gtfswrpgtf ymkiheesaa gpfakgaeis 61 dlsnssaigc gisinqeggd gsirvkessl rkkqermstk ypttmscrea fdqltscysi 121 ggqfrsyyry gdftscdkqv skfkfciihg ndpvkvqewy kdqvsnnkal entsgviwqe 181 rettank // LOCUS NP_010801 143 aa linear PLN 30-JUN-2025 DEFINITION dithiol glutaredoxin GRX2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010801 VERSION NP_010801.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180821.1 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12344. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..143 /product="dithiol glutaredoxin GRX2" /EC_number="1.11.1.9" /EC_number="2.5.1.18" /calculated_mol_wt="15730" Region 53..137 /region_name="GRX_GRXh_1_2_like" /note="Glutaredoxin (GRX) family, GRX human class 1 and 2 (h_1_2)-like subfamily; composed of proteins similar to human GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase; cd03419" /db_xref="CDD:239511" Site order(58,61,63,107..110,121..124) /site_type="other" /note="GSH binding site [chemical binding]" /db_xref="CDD:239511" Site order(61,64) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239511" CDS 1..143 /gene="GRX2" /locus_tag="YDR513W" /gene_synonym="TTR1" /coded_by="NM_001180821.1:1..432" /experiment="EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:12684511]" /experiment="EXISTENCE:direct assay:GO:0004602 glutathione peroxidase activity [PMID:12684511|PMID:18992757]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11958675|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11958675]" /experiment="EXISTENCE:genetic interaction:GO:0006749 glutathione metabolic process [PMID:23242256]" /experiment="EXISTENCE:mutant phenotype:GO:0015036 disulfide oxidoreductase activity [PMID:9571241]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:9571241]" /note="Cytoplasmic glutaredoxin; thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; GRX2 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form translocated to the mitochondrial matrix; GRX2 has a paralog, GRX1, that arose from the whole genome duplication" /db_xref="GeneID:852124" /db_xref="SGD:S000002921" ORIGIN 1 metnfsfdsn liviiiitlf atriiakrfl stpkmvsqet vahvkdligq kevfvaakty 61 cpyckatlst lfqelnvpks kalvleldem sngseiqdal eeisgqktvp nvyingkhig 121 gnsdletlkk ngklaeilkp vfq // LOCUS NP_010802 483 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR514C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010802 VERSION NP_010802.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180822.1 REFERENCE 1 (residues 1 to 483) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 483) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 483) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 483) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12345. Method: conceptual translation. FEATURES Location/Qualifiers source 1..483 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..483 /product="uncharacterized protein" /calculated_mol_wt="55359" Region 203..395 /region_name="DnaQ" /note="DNA polymerase III, epsilon subunit or related 3'-5' exonuclease [Replication, recombination and repair]; COG0847" /db_xref="CDD:440608" CDS 1..483 /locus_tag="YDR514C" /coded_by="NM_001180822.1:1..1452" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:21777356]" /note="hypothetical protein that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication" /db_xref="GeneID:852126" /db_xref="SGD:S000002922" ORIGIN 1 mssstkckka yeavvkmvth rfnskavrny hqpqglnrsl atrnaarvrg mvpsrrggvg 61 lykssssklm nklgrqktwi nefehfnslh eiaytpnial sseiqkylka letnyrsiye 121 ksselldkkl eeidkkwiek ngcipdaskd dveknlrkqy ladvqdvkne hipvmncepg 181 gsqfkylckt iellssnkti cfaidveafe fdtdivteig iaiydpreni yslmpiirsy 241 hlivaealpl rnkkfvcdfk dcfllgeslv lpleqcvefi qslinfymkc etdqdttwer 301 afvghaiagd ikwlkkigvh vpeldneltk pedsteskgv rkhvkmldte kiysmcygkk 361 gsslgkllrl fhlphaflhn agndayytll lmlklgdynf rkqigaddle tmgyrirewf 421 kreadepkil pmsyvlsvmn annskpkvdd kgrkkprdlv pqtefsgshw fqnaraafks 481 tlv // LOCUS NP_010803 447 aa linear PLN 30-JUN-2025 DEFINITION Slf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010803 VERSION NP_010803.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180823.3 REFERENCE 1 (residues 1 to 447) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 447) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 447) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 447) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12346. On Jul 30, 2012 this sequence version replaced NP_010803.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..447 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..447 /product="Slf1p" /calculated_mol_wt="50812" Region 3..443 /region_name="LHP1" /note="La protein, small RNA-binding pol III transcript stabilizing protein and related La-motif-containing proteins involved in translation [Posttranslational modification, protein turnover, chaperones / Translation, ribosomal structure and biogenesis]; COG5193" /db_xref="CDD:227520" CDS 1..447 /gene="SLF1" /locus_tag="YDR515W" /gene_synonym="SRO99" /coded_by="NM_001180823.3:1..1344" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10564276]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640|PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0006417 regulation of translation [PMID:10564276]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:8628314]" /note="RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; role in preventing L-A mycovirus pathogenesis; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852127" /db_xref="SGD:S000002923" ORIGIN 1 mssqnlndnp kntssaaedk kkqtsslkla pipttspwks sspdsntvip veelrdiskt 61 akpskngsgs ikltsntkwt pitpsviisg skdtnsksgk nsknsktnkk mkkrgkynnd 121 inkkdfngqt nstseisnvs nleskpldan akvnihsssg atangnikri tnnnnstngr 181 qsrnyqnrng ktrynnnsrh sqaannaisf pnnyqarpey ipnashwlnn nsrnsykqls 241 yfrqqqyynn inyqqqlqtp yyysmepifk siesiknqie fyfseenlkt deflrskfkk 301 andgfipmsl igkfyrmvnl slggdpnlil asmrevlqhk etnhleialg siegaqknma 361 ddfnplenyf irrenwaeya mesnfdendd etekyniekl lgpndldnys ymgypnffps 421 nengkksqsy dqgeisrqfe qnlqind // LOCUS NP_010804 500 aa linear PLN 30-JUN-2025 DEFINITION putative glucokinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010804 VERSION NP_010804.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180824.3 REFERENCE 1 (residues 1 to 500) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 500) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 500) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 500) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12347. On Jul 30, 2012 this sequence version replaced NP_010804.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..500 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..500 /product="putative glucokinase" /EC_number="2.7.1.2" /calculated_mol_wt="55790" Region 29..497 /region_name="ASKHA_NBD_GLK1-2_fungi" /note="nucleotide-binding domain (NBD) of hexokinase isozymes glucokinase-1 (GLK-1) and glucokinase-2 (GLK-2) from fungal hexokinase (HK) domain family; cd24088" /db_xref="CDD:466938" CDS 1..500 /gene="EMI2" /locus_tag="YDR516C" /coded_by="NM_001180824.3:1..1503" /experiment="EXISTENCE:direct assay:GO:0004396 hexokinase activity [PMID:34354536]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019318 hexose metabolic process [PMID:34354536]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:12586695]" /note="Hexokinase expressed during growth with low glucose levels; induced on non-fermentable carbon sources; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; protein abundance increases in response to DNA replication stress; EMI2 has a paralog, GLK1, that arose from the whole genome duplication" /db_xref="GeneID:852128" /db_xref="SGD:S000002924" ORIGIN 1 msfenlhkvn aealedavve icsslqvdaa kldeltayfi ecmekglnnt svgeektvdk 61 glpmiptyvt slpngtergv llaadlggth frvcsvtlng dgtfdmqqlk skipeeylnd 121 kdvtseelfs ylgrrtrafv rkhhpellks tgenikplkm gftfsypvdq tslssgtlir 181 wtksfkiedt vgkdvvrlyq eqldiqglsm invvaltndt vgtflshcyt sgsrpssage 241 isepvigcif gtgtngcyme dienikklpd elrtrllheg ktqmciniew gsfdnelkhl 301 satkydidid qkfspnpgyh lfekrisgmy lgellrnilv dlharglilg qyrnydqlph 361 rlktpfqlcs evlsrieidd stnlretels flqslrlptt feerkaiqnl vrsitrrsay 421 laavpiaail iktnalnkry hgeveigfdg yvieyypgfr smlrhalals pigtegerki 481 hlrlakdgsg vgaalcalva // LOCUS NP_010805 372 aa linear PLN 30-JUN-2025 DEFINITION Grh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010805 VERSION NP_010805.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180825.1 REFERENCE 1 (residues 1 to 372) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 372) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 372) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 372) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12348. Method: conceptual translation. FEATURES Location/Qualifiers source 1..372 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..372 /product="Grh1p" /calculated_mol_wt="40988" Region 1..372 /region_name="GRH1" /note="Peripheral Golgi membrane protein [Intracellular trafficking and secretion]; COG5233" /db_xref="CDD:227558" CDS 1..372 /gene="GRH1" /locus_tag="YDR517W" /coded_by="NM_001180825.1:1..1119" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:17261844]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10417390|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:17261844]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:17261844]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17261844]" /experiment="EXISTENCE:mutant phenotype:GO:0005801 cis-Golgi network [PMID:17261844]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17261844]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:20156967]" /experiment="EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:20156967]" /note="Acetylated cis-Golgi protein, homolog of human GRASP65; required for unconventional protein secretion (UPS) of Acb1p in response to starvation; forms amyloid-like fibrils under heat shock, and coacervates through liquid-liquid phase separation during starvation, as a precursor to compartment for unconventional protein secretion (CUPS) biogenesis; forms a complex with the coiled-coil protein Bug1p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852129" /db_xref="SGD:S000002925" ORIGIN 1 mfriaknlvr tfeqsvqdtl alsqdssnld affqsippnl lsaqlespvd avsegvkhtn 61 vnetlsglri vwvdemqfql qsffdyivgf nddpvpvvsn qhgfsypdyr ritsifnehc 121 grtlkvniws akggtfrdey isiiskesdd lddvslnhde rrpssgeahq fqalgfkvqw 181 tpliastfty hilnvnipdg paqsaglipd edyiigcqdg llatggetll qdivrsrany 241 dlvlyvynkv sdcvrpitvh igpdgrlgcn vgygflhrip tvkhcpqqaq qqgqddnpvp 301 vpvpveseta fvpsaftapp vptkkksknk kgtqplamdd yfnegrdkss taaksaesdi 361 lapppqkqss sd // LOCUS NP_010806 517 aa linear PLN 30-JUN-2025 DEFINITION protein disulfide isomerase EUG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010806 VERSION NP_010806.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180826.1 REFERENCE 1 (residues 1 to 517) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 517) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 517) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 517) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12349. Method: conceptual translation. FEATURES Location/Qualifiers source 1..517 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..517 /product="protein disulfide isomerase EUG1" /EC_number="5.3.4.1" /calculated_mol_wt="58851" Region 33..487 /region_name="ER_PDI_fam" /note="protein disulfide isomerase, eukaryotic; TIGR01130" /db_xref="CDD:273457" CDS 1..517 /gene="EUG1" /locus_tag="YDR518W" /coded_by="NM_001180826.1:1..1554" /experiment="EXISTENCE:direct assay:GO:0003756 protein disulfide isomerase activity [PMID:16002399]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015035 protein-disulfide reductase activity [PMID:16002399]" /experiment="EXISTENCE:direct assay:GO:0019153 protein-disulfide reductase (glutathione) activity [PMID:16002399]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16002399]" /experiment="EXISTENCE:genetic interaction:GO:0003756 protein disulfide isomerase activity [PMID:11157982]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:11157982]" /experiment="EXISTENCE:genetic interaction:GO:0015035 protein-disulfide reductase activity [PMID:11157982]" /experiment="EXISTENCE:mutant phenotype:GO:0003756 protein disulfide isomerase activity [PMID:11157982]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:16002399]" /note="Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER" /db_xref="GeneID:852130" /db_xref="SGD:S000002926" ORIGIN 1 mqvttrfisa ivsfclfasf tlaensarat pgsdllvlte kkfksfiesh plvlveffap 61 wclhsqilrp hleeaasilk ehnvpvvqid ceansmvclq qtintyptlk ifkngrifdg 121 qvyrgvkitd eitqymiqly easviylnse deiqpylena tlpvvinrgl tglnetyqev 181 aldlaedyvf lslldsedks lsihlpntte pilfdgnvds lvgnsvaltq wlkvvilpyf 241 tdiepdlfpk yissnlplay ffytseeele dytdlftqlg kenrgqinfi alnstmfphh 301 vrflnmreqf plfaihnmin nlkyglpqlp eeeyaklekp qpldrdmivq lvkdyregta 361 kpivkseeip keqksnvyki vgkthddivh dddkdvlvky yatwcihskr fapiyeeian 421 vlasdesvrd kiliaevdsg andilsfpvt gyptialypa gnnskpiifn kirnledvfe 481 fikesgthhi dgqaiydklh qakdsevste dtvhdel // LOCUS NP_010807 135 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase family protein FPR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010807 VERSION NP_010807.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180827.3 REFERENCE 1 (residues 1 to 135) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 135) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 135) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 135) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12350. On Jul 30, 2012 this sequence version replaced NP_010807.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..135 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..135 /product="peptidylprolyl isomerase family protein FPR2" /EC_number="5.2.1.8" /calculated_mol_wt="14356" Region 36..129 /region_name="FKBP_C" /note="FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254" /db_xref="CDD:459735" CDS 1..135 /gene="FPR2" /locus_tag="YDR519W" /gene_synonym="FKB2" /coded_by="NM_001180827.3:1..408" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:1380159]" /experiment="EXISTENCE:direct assay:GO:0005528 FK506 binding [PMID:1380159]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:1380159]" /note="Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2" /db_xref="GeneID:852131" /db_xref="SGD:S000002927" ORIGIN 1 mmfniylfvt ffstilagsl sdleigiikr ipvedclika mpgdkvkvhy tgsllesgtv 61 fdssysrgsp iafelgvgrv ikgwdqgvag mcvgekrklq ipsslayger gvpgvippsa 121 dlvfdvelvd vksaa // LOCUS NP_010808 772 aa linear PLN 30-JUN-2025 DEFINITION Urc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010808 VERSION NP_010808.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180828.3 REFERENCE 1 (residues 1 to 772) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 772) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 772) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 772) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 772) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 772) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 772) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 772) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 772) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12351. On Jul 30, 2012 this sequence version replaced NP_010808.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..772 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..772 /product="Urc2p" /calculated_mol_wt="88517" Region 66..109 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(67,71,76..79,81,84,96) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(72,75,82,91,94,101) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..772 /gene="URC2" /locus_tag="YDR520C" /gene_synonym="RRT4" /coded_by="NM_001180828.3:1..2319" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]" /note="Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism" /db_xref="GeneID:852133" /db_xref="SGD:S000002928" ORIGIN 1 mdinsnasvs prpdglpmta gynsasgkvr nsirsiinhp edsarakers etnspknngn 61 kkprkkrktf scdtcrrvkt rcdfepfigk cyrcnvlqld cslarnkdne ilntlredgl 121 lkkinsinhn lgsfshlnad spnesqssfe kngtvnfdny midkrlssle ehikslhqkm 181 dliittakms ynsdikgpgd diqnvdfssn ktydsrltsg setirktgey rkenlflngf 241 klkesplkll hdiderlfps katskaakla gqqrpyavar vnflhfyenn qelchklake 301 flvrshfwii pggrkeidve yahshlfits vftiiamsfa dndkyaaeqe ilyplverll 361 tntltmfekl tafdieaily ccmfhisrka kryrqlkfns lvlsnfalns llhvidfyqi 421 kdrvlvkevy npedlyhlri lnsltacyle ysisygdire qddmlkefnk lvakfpqanf 481 gddikisein lgdivngifi nlknyfaqcl ddfnndrygg nadtfifvfp elnywlknwe 541 ellakdgagv llftfdfyhi micrtfitef sstlksnqrf lklilntmke hsfsllngfl 601 rlpptlirga piftchqlvy acltlcdyly wfdsserqrv lslctkvywh lstigekmne 661 atdnvgkiik siidtsktri nfgslskens dndkmstnan nytgagnlha akpatsptnv 721 gtlhenlsss hfmipdvdqf nsfedffqdf fdslkpnsqk mftsdkkteq tt // LOCUS NP_010810 502 aa linear PLN 30-JUN-2025 DEFINITION Sps2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010810 VERSION NP_010810.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180830.1 REFERENCE 1 (residues 1 to 502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 502) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12352. Method: conceptual translation. FEATURES Location/Qualifiers source 1..502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..502 /product="Sps2p" /calculated_mol_wt="55808" CDS 1..502 /gene="SPS2" /locus_tag="YDR522C" /coded_by="NM_001180830.1:1..1509" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]" /note="Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component" /db_xref="GeneID:852134" /db_xref="SGD:S000002930" ORIGIN 1 mpiwktqtff tsisviqivn ketkvstkke kdsmlnqlnt ilrflflflq likssaavep 61 nggpnildhn imlvntnati pkkeqtdfev isptkqtqvd edckkglyhi enagnlielq 121 akcwkvvgni eissnysgsl idlglireie gdliiknnkh ifriqgynle slgkleldsl 181 tsfvsldfpa lkevetvdwr vlpilssvvi ngnikkikni iisdtaltsi dyfnnvkkvd 241 ifninnnrfl enlfaslesv tkqltvhsna keleldlsnl htvenmtikd vseiklakls 301 svnsslefie nqfsslelpl lakvqgtlgl idnknlkkln fsnatdiqgg lmianntela 361 kidffpklrq iggaiyfegs fdkidlpelk lvkgsayiks sseelnceef tspkagrsii 421 rggkiectsg mkskmlnvde egnvlgkqet dndngkkekg kngaksqgss kkmensapkn 481 ifidafkmsv yavftvlfsi if // LOCUS NP_010811 490 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase SPS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010811 VERSION NP_010811.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180831.1 REFERENCE 1 (residues 1 to 490) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 490) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 490) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 490) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12353. Method: conceptual translation. FEATURES Location/Qualifiers source 1..490 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..490 /product="putative serine/threonine protein kinase SPS1" /EC_number="2.7.11.1" /calculated_mol_wt="55573" Region 16..291 /region_name="STKc_MST3_like" /note="Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; cd06609" /db_xref="CDD:270786" Site order(24..28,32,45,47,77,93..96,99..100,103,141,143..146, 148,158..159,162,175..178,180,209,218) /site_type="active" /db_xref="CDD:270786" Site order(24..28,32,45,47,64,77,93..96,99..100,103,145..146, 148,159) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270786" Site order(27..28,141,143..145,162,175..178,180,209,218) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270786" Site order(158..169,171..180) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270786" CDS 1..490 /gene="SPS1" /locus_tag="YDR523C" /coded_by="NM_001180831.1:1..1473" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:27182947]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25409301|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25409301|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:3023934]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15755916]" /experiment="EXISTENCE:mutant phenotype:GO:0051229 meiotic spindle disassembly [PMID:32788308]" /experiment="EXISTENCE:mutant phenotype:GO:1903024 positive regulation of ascospore-type prospore membrane formation [PMID:27182947|PMID:32788308]" /experiment="EXISTENCE:mutant phenotype:GO:1904750 negative regulation of protein localization to nucleolus [PMID:32788308]" /note="STE20-family GCKIII protein kinase; required for prospore membrane closure, efficient spore packaging, and localization of enzymes involved in spore wall synthesis; component of a non-canonical Hippo pathway with Cdc15p involved in spindle disassembly and sustained release of Cdc14p during anaphase II; forms a complex with Cdc15p; phosphorylation requires Cdc15p; required for Ssp1p phosphorylation and turnover; interacts with 14-3-3 proteins; expressed in late meiosis; nuclear and cytoplasmic" /db_xref="GeneID:852135" /db_xref="SGD:S000002931" ORIGIN 1 meskeisirs rtppsklysi qscigrgnfg dvykavdrvt qeivaikvvn lehsdediel 61 laqeifflae lksplitnyi atmledvsmw ivmeycgggs csdllkrsyv nglpeekvsf 121 iihevtlglk ylheqrkihr dikaanilln eegmvklgdf gvsghirstl krdtfvgtpy 181 wmapevvcce vdgynekadi wslgittyel lkglpplsky dpmkvmtnlp krkppklqgp 241 fsdaakdfva gclvktpadr psaynllsfe fvknititnl ksdvdlikqk kvqerytkvp 301 kyplqnrlyk nsntvrgkef wnfestrlst tqiskeelsp itqdsptssl nmespyllhg 361 qtvtpitnps sssfrkctqp vfeldsgmdi dsgcpnaqae teivplsnhn kkhkkndiqa 421 lkiekfdylk nivshilnrm ydrarddetr kyvnemlkqf ikteanvpgf nevfieeisl 481 rieaikkgfv // LOCUS NP_010812 482 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein AGE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010812 VERSION NP_010812.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180832.3 REFERENCE 1 (residues 1 to 482) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 482) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 482) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 482) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12354. On Jul 30, 2012 this sequence version replaced NP_010812.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..482 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..482 /product="GTPase-activating protein AGE1" /calculated_mol_wt="54363" Region 164..480 /region_name="COG5347" /note="GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]" /db_xref="CDD:227651" CDS 1..482 /gene="AGE1" /locus_tag="YDR524C" /gene_synonym="SAT1" /coded_by="NM_001180832.3:1..1449" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:12627398]" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:21135091]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:21135091]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:21135091]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9677411]" /experiment="EXISTENCE:genetic interaction:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:9677411]" /note="ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif" /db_xref="GeneID:852136" /db_xref="SGD:S000002932" ORIGIN 1 mdfyttdink nvvplfskgt vartaskaqy pswcnnalkl tnillkslrc kfqtnrcedd 61 rgfevycvil ksiallmaak eslillqipp slpsgfpfrs pqlsftylst rlsgsqhkst 121 hshhinhqth pihssssnsn snnriptktd sskqhtqhfs fanagasnrd ellsivrkid 181 ksnlkccdcg statvewvsi nllcilcikc sgvhrslgsh iskirsltld nftslelmhl 241 lqnnvsnsnv naiyesnlrn fpvkkitans ddserskfii dkyqfkkfvi dsnqgreasl 301 kslikaihld svfmmqraia qskyslrelt asekeqndln hssifqyslk hyeivdgtpi 361 ffitefllcn gihidnlpki ttnwspkvle ywetklemyg tfqavntsrp rsgphlnmhs 421 nvdsassynk khdlrvnipe rsasaskrws lssipkssqn lmsptnlltm hkslklakkd 481 kk // LOCUS NP_878066 29 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR524W-C [Saccharomyces cerevisiae S288C]. ACCESSION NP_878066 VERSION NP_878066.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184632.3 REFERENCE 1 (residues 1 to 29) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 29) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 29) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 29) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12355. On Jul 30, 2012 this sequence version replaced NP_878066.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..29 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..29 /product="uncharacterized protein" /calculated_mol_wt="3403" CDS 1..29 /locus_tag="YDR524W-C" /gene_synonym="YDR524W-A" /coded_by="NM_001184632.3:1..90" /note="hypothetical protein; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin" /db_xref="GeneID:1466437" /db_xref="SGD:S000028740" ORIGIN 1 mkrsyktlpt yffsffgpfk eravfllvl // LOCUS NP_878067 66 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YDR524C-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878067 VERSION NP_878067.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184631.1 REFERENCE 1 (residues 1 to 66) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 66) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 66) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 66) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12356. Method: conceptual translation. FEATURES Location/Qualifiers source 1..66 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..66 /product="uncharacterized protein" /calculated_mol_wt="6193" CDS 1..66 /locus_tag="YDR524C-B" /coded_by="NM_001184631.1:1..201" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication" /db_xref="GeneID:1466438" /db_xref="SGD:S000028739" ORIGIN 1 mqfktivaaf atvaavqaan vstngsnrtn gsnttstkis tgaaasnalg agvfgaavaa 61 gvaflf // LOCUS NP_001335763 109 aa linear PLN 30-JUN-2025 DEFINITION Api2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335763 VERSION NP_001335763.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348819.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80283. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..109 /product="Api2p" /calculated_mol_wt="12395" CDS 1..109 /gene="API2" /locus_tag="YDR525W" /coded_by="NM_001348819.1:1..330" /note="hypothetical protein; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology" /db_xref="GeneID:852137" /db_xref="SGD:S000002933" ORIGIN 1 mekkiknfss slymrrkark ttamthstis hvtnvkkami ffllsfshfs sgysackkkr 61 rgsglryfgn klwrptprsg qsgqsrpktg phgsqrvvfl elkkaqrwa // LOCUS NP_010814 79 aa linear PLN 30-JUN-2025 DEFINITION Sna2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010814 VERSION NP_010814.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184329.1 REFERENCE 1 (residues 1 to 79) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 79) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 79) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 79) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12357. Method: conceptual translation. FEATURES Location/Qualifiers source 1..79 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..79 /product="Sna2p" /calculated_mol_wt="9049" Region 5..54 /region_name="Pmp3" /note="Proteolipid membrane potential modulator; pfam01679" /db_xref="CDD:460290" CDS 1..79 /gene="SNA2" /locus_tag="YDR525W-A" /coded_by="NM_001184329.1:1..240" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20406419|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" /db_xref="GeneID:852138" /db_xref="SGD:S000007236" ORIGIN 1 mhardwflvf iaifipplav wlkrgfftkd llinfllfll gffpglihal yvischpyee 61 nearyshlss sddnygsla // LOCUS NP_010816 439 aa linear PLN 30-JUN-2025 DEFINITION Rba50p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010816 VERSION NP_010816.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180835.4 REFERENCE 1 (residues 1 to 439) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 439) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 439) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 439) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12358. On Jul 30, 2012 this sequence version replaced NP_010816.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..439 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..439 /product="Rba50p" /calculated_mol_wt="50061" Region <62..>289 /region_name="235kDa-fam" /note="reticulocyte binding/rhoptry protein; TIGR01612" /db_xref="CDD:130673" Region 79..124 /region_name="RPAP1_N" /note="RPAP1-like, N-terminal; pfam08621" /db_xref="CDD:462539" Region 289..357 /region_name="RPAP1_C" /note="RPAP1-like, C-terminal; pfam08620" /db_xref="CDD:462538" CDS 1..439 /gene="RBA50" /locus_tag="YDR527W" /coded_by="NM_001180835.4:1..1320" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:15282305]" /note="Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1" /db_xref="GeneID:852139" /db_xref="SGD:S000002935" ORIGIN 1 mdllgdivek dtsdsvesnd ngtlstnncg tgfpelykpk kisswkerlr ekraqkkkts 61 gkdaekqqts tdaplseaks ihnenikvlq gmsdeqivqe redlynsldp kliakllkni 121 nkrakdennt plfaeiegas gtwvggnkqg iydlppldde dvdvaleirp mlgkdakhvq 181 feeagkekdv eeeaktnddv ddiapldfqm aqcidhmkne elfkdvhfik eesqneinle 241 kldindpnfn dklhekyfpd lpkevdklkw mqpvqqktdk nyiiedvsec rfdfngdlvp 301 ptrqidstih sglhhhsdsp elagytivel ehlarstfps qrciaiqtlg rilyklgqks 361 yyqlvpeida dtykedgsis nvmdkiysmf wdlikdgkvi esleissdek ftrnlsvrny 421 aidalwlwkq gggdfrtkk // LOCUS NP_010817 423 aa linear PLN 30-JUN-2025 DEFINITION Hlr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010817 VERSION NP_010817.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180836.3 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12359. On Jul 30, 2012 this sequence version replaced NP_010817.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..423 /product="Hlr1p" /calculated_mol_wt="47447" CDS 1..423 /gene="HLR1" /locus_tag="YDR528W" /coded_by="NM_001180836.3:1..1272" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:11532139]" /note="Protein involved in regulation of cell wall composition and integrity; also involved in cell wall response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; HLR1 has a paralog, LRE1, that arose from the whole genome duplication" /db_xref="GeneID:852141" /db_xref="SGD:S000002936" ORIGIN 1 menlcpppps qmkdfstppr nrhrhkrsfa isgdfeflkq pasapvlpsa ydsptfentp 61 rrvsgmsvtm pdesqnesal lnspsprffi seastysspi kgvpdaiinl ddvlinkpkm 121 crshrktksv pvkldefyss hkcssvpelt ineeideddt npqllepvkp lsstslstdm 181 nedkkmtlkn arshnslkiq aqkqryynsa rylplnsedr atdpqiltkq ssvtslfssr 241 sitpvscnin nagrinaisg nylddvlydl dtpattliqd idnlqtsine rvrlspqsss 301 ikkyfskdgk svssfnfqsq ecdmvsfted fahvtslsss ildsekqtdd eeeesipeei 361 lrgeplhvyn etsgsdksvi lptkqksapi nkdskhsstq yeeksfkknr kfkifaklfc 421 trk // LOCUS NP_010818 127 aa linear PLN 30-JUN-2025 DEFINITION ubiquinol--cytochrome-c reductase subunit 7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010818 VERSION NP_010818.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180837.1 REFERENCE 1 (residues 1 to 127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 127) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12360. Method: conceptual translation. FEATURES Location/Qualifiers source 1..127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..127 /product="ubiquinol--cytochrome-c reductase subunit 7" /calculated_mol_wt="14434" Region 19..118 /region_name="UCR_14kD" /note="Ubiquinol-cytochrome C reductase complex 14kD subunit; pfam02271" /db_xref="CDD:460519" CDS 1..127 /gene="QCR7" /locus_tag="YDR529C" /gene_synonym="COR4; CRO1; UCR7" /coded_by="NM_001180837.1:1..384" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:10873857]" /experiment="EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:2540976]" /experiment="EXISTENCE:mutant phenotype:GO:0008121 quinol-cytochrome-c reductase activity [PMID:2540976]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:2540976]" /experiment="EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:11556808]" /note="Subunit 7 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly" /db_xref="GeneID:852142" /db_xref="SGD:S000002937" ORIGIN 1 mpqsftsiar igdyilkspv lsklcvpvan qfinlagykk lglkfddlia eenpimqtal 61 rrlpedesya rayriirahq telthhllpr newikaqedv pyllpyilea eaaakekdel 121 dnievsk // LOCUS NP_010819 325 aa linear PLN 30-JUN-2025 DEFINITION bifunctional AP-4-A phosphorylase/ADP sulfurylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010819 VERSION NP_010819.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180838.1 REFERENCE 1 (residues 1 to 325) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 325) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 325) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 325) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12361. Method: conceptual translation. FEATURES Location/Qualifiers source 1..325 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..325 /product="bifunctional AP-4-A phosphorylase/ADP sulfurylase" /EC_number="2.7.7.5" /EC_number="2.7.7.53" /calculated_mol_wt="36710" Region 43..296 /region_name="APA2" /note="ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; COG4360" /db_xref="CDD:443494" CDS 1..325 /gene="APA2" /locus_tag="YDR530C" /coded_by="NM_001180838.1:1..978" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity [PMID:2174863]" /experiment="EXISTENCE:direct assay:GO:0009164 nucleoside catabolic process [PMID:2174863]" /experiment="EXISTENCE:genetic interaction:GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity [PMID:2174863]" /experiment="EXISTENCE:genetic interaction:GO:0009164 nucleoside catabolic process [PMID:2174863]" /experiment="EXISTENCE:mutant phenotype:GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity [PMID:2174863]" /experiment="EXISTENCE:mutant phenotype:GO:0009164 nucleoside catabolic process [PMID:2174863]" /note="Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication" /db_xref="GeneID:852143" /db_xref="SGD:S000002938" ORIGIN 1 mieenlkqki hdkfvaakkn ghlkvthaes kklkdpqttt qywvtfapsl alkpdankns 61 dskaedpfan pdeelvvted lngdgeykll lnkfpvvpeh sllvtsefkd qrsaltpsdl 121 mtaynvlcsl qgdkdddvtc erylvfyncg phsgssqdhk hlqimqmpek fipfqdvlcn 181 gkdhflptfn aeplqddkvs fahfvlplpe ssdqvdedll amcyvslmqr altffqdwtn 241 espeltksyn vlltkkwicv vprshaksgp plmlninstg ycgmilvkdr eklenltedp 301 hlvdksllqc gfpntagqkp teyhy // LOCUS NP_010820 367 aa linear PLN 30-JUN-2025 DEFINITION pantothenate kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010820 VERSION NP_010820.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180839.3 REFERENCE 1 (residues 1 to 367) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 367) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 367) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 367) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12362. On Jul 30, 2012 this sequence version replaced NP_010820.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..367 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..367 /product="pantothenate kinase" /EC_number="2.7.1.33" /calculated_mol_wt="40772" Region 21..354 /region_name="ASKHA_NBD_PanK-II_Pank4" /note="nucleotide-binding domain (NBD) of pantothenate kinase 4 (Pank4) from type II pantothenate kinase (PanK-II) subfamily; cd24123" /db_xref="CDD:466973" CDS 1..367 /gene="CAB1" /locus_tag="YDR531W" /coded_by="NM_001180839.3:1..1104" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:33396642|PMID:14690591]" /experiment="EXISTENCE:genetic interaction:GO:0015937 coenzyme A biosynthetic process [PMID:19266201]" /experiment="EXISTENCE:mutant phenotype:GO:0004594 pantothenate kinase activity [PMID:19266201]" /experiment="EXISTENCE:mutant phenotype:GO:0008204 ergosterol metabolic process [PMID:31409644]" /note="Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase; cytoplasmic enzyme that catalyzes the first committed step in the universal biosynthetic pathway for coenzyme A (CoA) synthesis; transcription is regulated by Upc2p via a sterol response element; overexpressed human homologs, PANK1 and PANK3, complement yeast hypomorphic alleles, while PANK2, a gene implicated in pantothenate-kinase associated neurodegeneration, partially complements after the mitochondrial transit peptide is removed" /db_xref="GeneID:852144" /db_xref="SGD:S000002939" ORIGIN 1 mpritqeisy ncdygdntfn laidiggtla kvvfspihsn rlmfytiete kidkfmellh 61 siikehnngc yrmthiiatg ggafkfydll yenfpqikgi srfeemegli hgldffihei 121 pdevftyndq dgeriiptss gtmdskaiyp yllvnigsgv silkvtepnn fsrvggsslg 181 ggtlwgllsl itgaqtydqm ldwaqegdns svdmlvgdiy gtdynkiglk ssaiassfgk 241 vfqnrmtsnk slennenkly sshesieknn gqmfknpdic ksllfaisnn igqiaylqak 301 inniqniyfg gsytrghltt mntlsyainf wsqgskqaff lkhegylgam gaflsasrhs 361 stkktst // LOCUS NP_010821 385 aa linear PLN 30-JUN-2025 DEFINITION Kre28p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010821 VERSION NP_010821.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180840.3 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12363. On Jul 30, 2012 this sequence version replaced NP_010821.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..385 /product="Kre28p" /calculated_mol_wt="44544" Region 1..382 /region_name="Kre28" /note="Spindle pole body component; pfam17097" /db_xref="CDD:407241" CDS 1..385 /gene="KRE28" /locus_tag="YDR532C" /coded_by="NM_001180840.3:1..1158" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:14565975]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:19893618]" /note="Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Spc105p; modified by sumoylation" /db_xref="GeneID:852145" /db_xref="SGD:S000002940" ORIGIN 1 mdtgsasikd yetvltdied siavsseevl nnqelrlknt lheitssila ineenkfvnp 61 lrndesldve gkevfvnpki lsakikefnk lmellkltyl eqetldyffr ftlsstkplq 121 ldsekdpqfv klnervndlk eeisnvqesk ieqikaeiqe tghnfaerqd linelyleat 181 gdiencwdsl nelknltnke dknmmgekdt ilnssdsddf veetytnwqk llflqkqnqr 241 ltkelkemhe vknqiirkge qskkedsghl maneselcqs inlltkfwek hfllkgsktt 301 ilnfeiftql gkvqfeikdm qyiiaislsd lkrpmikdit ilqkaggniv tdieasskfn 361 nkyrnntkvq ifevmddiis eltne // LOCUS NP_010822 237 aa linear PLN 30-JUN-2025 DEFINITION glutathione-independent methylglyoxalase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010822 VERSION NP_010822.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180841.1 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12364. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..237 /product="glutathione-independent methylglyoxalase" /EC_number="4.2.1.130" /calculated_mol_wt="25539" Region 5..235 /region_name="GATase1_Ydr533c_like" /note="Type 1 glutamine amidotransferase (GATase1)-like domain found in Saccharomyces cerevisiae Ydr533c protein; cd03147" /db_xref="CDD:153241" Site order(107,139) /site_type="active" /note="potential oxyanion hole [active]" /db_xref="CDD:153241" Site order(138..139,170) /site_type="active" /note="potential catalytic triad [active]" /db_xref="CDD:153241" Site 138 /site_type="active" /note="conserved cys residue [active]" /db_xref="CDD:153241" Site order(159,161,197,208..209,212,230) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153241" CDS 1..237 /gene="HSP31" /locus_tag="YDR533C" /coded_by="NM_001180841.1:1..714" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:24706893]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:26306045]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:24706893]" /experiment="EXISTENCE:direct assay:GO:0019172 glyoxalase III activity [PMID:24302734]" /experiment="EXISTENCE:direct assay:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:24302734]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:26306045]" /experiment="EXISTENCE:mutant phenotype:GO:0031669 cellular response to nutrient levels [PMID:24706893]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17395014]" /note="Methylglyoxalase that converts methylglyoxal to D-lactate; involved in oxidative stress resistance, diauxic shift, and stationary phase survival; has similarity to E. coli Hsp31 and C. albicans Glx3p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852146" /db_xref="SGD:S000002941" ORIGIN 1 mapkkvllal tsyndvfysd gaktgvfvve alhpfntfrk egfevdfvse tgkfgwdehs 61 lakdflngqd etdfknkdsd fnktlakikt pkevnaddyq iffasaghgt lfdypkakdl 121 qdiaseiyan ggvvaavchg paifdgltdk ktgrpliegk sitgftdvge tilgvdsilk 181 aknlatvedv akkygakyla pvgpwddysi tdgrlvtgvn pasahstavr sidalkn // LOCUS NP_010823 528 aa linear PLN 30-JUN-2025 DEFINITION Fit1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010823 VERSION NP_010823.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180842.1 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12365. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..528 /product="Fit1p" /calculated_mol_wt="52359" CDS 1..528 /gene="FIT1" /locus_tag="YDR534C" /coded_by="NM_001180842.1:1..1587" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0015891 siderophore transport [PMID:12196168]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall" /db_xref="GeneID:852147" /db_xref="SGD:S000002942" ORIGIN 1 mklssafvls aitvaalges itttitatkn ghvytktvtq datfvwageg aavtsavtea 61 stvaatsaaa etsvaaetsi vepstsaqgt sadegsgssi tttitatkng hvytktvtqd 121 atfvwtgege rapastvatv etsvaaetsv aepstsaqgt sadegsgssi tttitatkng 181 hvytktvtqd atfvwtgege rapvstvatv etaaspvtsv aepsastdeg sgssitttit 241 atknghvytk tvtqdatfvw tgegerapas tvatssisai eipstteasi veassavets 301 saaetssave tssavetssa vetssaaets saaetssave tssaveissa vetsavetss 361 ssstiettsv kslsptqtsl sssvqasspi etssaaktss vvptfssttt enssnsksts 421 avvastttss essativtpt rigqaytess srdaqsvrth esnnwsssss astkmvssit 481 rvqtttagif tngkssttpq ivnytgaads iaagtglmga alaavifl // LOCUS NP_010825 569 aa linear PLN 30-JUN-2025 DEFINITION glucose-inactivated glycerol proton symporter STL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010825 VERSION NP_010825.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180844.3 REFERENCE 1 (residues 1 to 569) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 569) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 569) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 569) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12366. On Jul 30, 2012 this sequence version replaced NP_010825.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..569 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..569 /product="glucose-inactivated glycerol proton symporter STL1" /calculated_mol_wt="63401" Region 32..488 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(42,46,176,179..180,183,302..303,307..308,311..312, 340,400..401,404..405,409,432..433,436) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..569 /gene="STL1" /locus_tag="YDR536W" /coded_by="NM_001180844.3:1..1710" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15703210]" /experiment="EXISTENCE:direct assay:GO:0015295 solute:proton symporter activity [PMID:15703210|PMID:17434487]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015295 solute:proton symporter activity [PMID:17434487|PMID:15703210]" /experiment="EXISTENCE:mutant phenotype:GO:0015793 glycerol transmembrane transport [PMID:15703210|PMID:17434487]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:15703210]" /note="Glycerol proton symporter of the plasma membrane; subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock" /db_xref="GeneID:852149" /db_xref="SGD:S000002944" ORIGIN 1 mkdlklsnfk gkfisrtshw gltgkklryf itiasmtgfs lfgydqglma slitgkqfny 61 efpatkengd hdrhatvvqg attscyelgc fagslfvmfc gerigrkpli lmgsvitiig 121 avistcafrg ywalgqfiig rvvtgvgtgl ntstipvwqs emskaenrgl lvnlegstia 181 fgtmiaywid fglsytnssv qwrfpvsmqi vfalfllafm iklpesprwl isqsrteear 241 ylvgtlddad pndeevitev amlhdavnrt khekhslssl fsrgrsqnlq raliaastqf 301 fqqftgcnaa iyystvlfnk tikldyrlsm iiggvfatiy alstigsffl ieklgrrklf 361 llgatgqavs ftitfaclvk enkenargaa vglflfitff glsllslpwi yppeiasmkv 421 rastnafstc tnwlcnfavv mftpifigqs gwgcylffav mnylyipvif ffypetagrs 481 leeidiifak ayedgtqpwr vanhlpklsl qevedhanal gsyddemeke dfgedrvedt 541 ynqingdnss sssniknedt vndkanfeg // LOCUS NP_010827 242 aa linear PLN 30-JUN-2025 DEFINITION phenylacrylic acid decarboxylase PAD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010827 VERSION NP_010827.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180846.3 REFERENCE 1 (residues 1 to 242) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 242) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 242) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 242) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12367. On Jul 30, 2012 this sequence version replaced NP_010827.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..242 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..242 /product="phenylacrylic acid decarboxylase PAD1" /EC_number="2.5.1.129" /calculated_mol_wt="26602" Region 56..236 /region_name="ubiX_pad" /note="UbiX family flavin prenyltransferase; TIGR00421" /db_xref="CDD:129515" CDS 1..242 /gene="PAD1" /locus_tag="YDR538W" /gene_synonym="POF1" /coded_by="NM_001180846.3:1..729" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0009056 catabolic process [PMID:11693915]" /experiment="EXISTENCE:mutant phenotype:GO:0016831 carboxy-lyase activity [PMID:11693915|PMID:8181743]" /experiment="EXISTENCE:mutant phenotype:GO:0046281 cinnamic acid catabolic process [PMID:20471595|PMID:8181743]" /note="Phenylacrylic acid decarboxylase; decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; confers resistance to cinnamic acid; overexpression of both Pad1p and Fdc1p increases cinnamic acid decarboxylase activity due to the Pad1p-catalyzed formation of a diffusible cofactor required for Fdc1p activity; contains mRNA binding activity; homolog of E. coli UbiX" /db_xref="GeneID:852150" /db_xref="SGD:S000002946" ORIGIN 1 mllfprrtni affkttgifa nfpllgrtit tspsflthkl skevtrasts pprpkrivva 61 itgatgvalg irllqvlkel svethlvisk wgaatmkyet dwephdvaal atktysvrdv 121 sacissgsfq hdgmivvpcs mkslaairig ftedlitraa dvsikenrkl llvtretpls 181 sihlenmlsl cragviifpp vpafytrpks lhdlleqsvg rildcfgiha dtfprwegik 241 sk // LOCUS NP_010828 503 aa linear PLN 30-JUN-2025 DEFINITION putative phenylacrylic acid decarboxylase FDC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010828 VERSION NP_010828.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180847.1 REFERENCE 1 (residues 1 to 503) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 503) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 503) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 503) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12368. Method: conceptual translation. FEATURES Location/Qualifiers source 1..503 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..503 /product="putative phenylacrylic acid decarboxylase FDC1" /EC_number="4.1.1.102" /calculated_mol_wt="56033" Region 10..463 /region_name="TIGR00148" /note="UbiD family decarboxylase" /db_xref="CDD:129252" CDS 1..503 /gene="FDC1" /locus_tag="YDR539W" /coded_by="NM_001180847.1:1..1512" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016831 carboxy-lyase activity [PMID:25647642|PMID:25862228]" /experiment="EXISTENCE:direct assay:GO:0033494 ferulate metabolic process [PMID:25862228]" /experiment="EXISTENCE:mutant phenotype:GO:0016831 carboxy-lyase activity [PMID:25862228]" /experiment="EXISTENCE:mutant phenotype:GO:0033494 ferulate metabolic process [PMID:25862228]" /experiment="EXISTENCE:mutant phenotype:GO:0046281 cinnamic acid catabolic process [PMID:20471595]" /note="Ferulic acid decarboxylase; involved in the decarboxylation of aromatic carboxylic acids such as phenylacrylic (cinnamic) acid, ferulic acid and coumaric acid and formation of the corresponding vinyl derivatives; overexpression of both Pad1p and Fdc1p increases decarboxylase activity due to the Pad1p-catalyzed formation of a diffusible cofactor required for Fdc1p activity; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm in an HTP study" /db_xref="GeneID:852152" /db_xref="SGD:S000002947" ORIGIN 1 mrklnpalef rdfiqvlkde ddlieiteei dpnlevgaim rkayeshlpa plfknlkgas 61 kdlfsilgcp aglrskekgd hgriahhlgl dpkttikeii dylleckeke plppitvpvs 121 sapckthils eekihlqslp tpylhvsdgg kylqtygmwi lqtpdkkwtn wsiargmvvd 181 dkhitglvik pqhirqiads waaigkanei pfalcfgvpp aailvssmpi pegvsesdyv 241 gailgesvpv vkcetndlmv patsemvfeg tlsltdthle gpfgemhgyv fksqghpcpl 301 ytvkamsyrd nailpvsnpg lctdethtli gslvateake laiesglpil dafmpyeaqa 361 lwlilkvdlk glqalkttpe efckkvgdiy frtkvgfivh eiilvaddid ifnfkeviwa 421 yvtrhtpvad qmafddvtsf plapfvsqss rsktmkggkc vtncifrqqy ersfdyitcn 481 fekgypkglv dkvnenwkry gyk // LOCUS NP_010829 179 aa linear PLN 30-JUN-2025 DEFINITION Irc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010829 VERSION NP_010829.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180848.1 REFERENCE 1 (residues 1 to 179) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 179) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 179) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 179) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12369. Method: conceptual translation. FEATURES Location/Qualifiers source 1..179 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..179 /product="Irc4p" /calculated_mol_wt="21387" Region 21..166 /region_name="DUF1706" /note="Protein of unknown function (DUF1706); pfam08020" /db_xref="CDD:429789" CDS 1..179 /gene="IRC4" /locus_tag="YDR540C" /coded_by="NM_001180848.1:1..540" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="Protein similar to bacterial secreted DfsB proteins; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus" /db_xref="GeneID:852153" /db_xref="SGD:S000002948" ORIGIN 1 mreytskkel keeiekkyek ydaefetise sqkdekvetv drtpsenlsy qlgwvnllle 61 weakeiagyn vetpapgykw nnlgglyqsf ykkygiysik eqraklreav nevykwistl 121 sddelfqagn rkwattkamw pvykwihint vapftnfrgk irkwkrlvpe eqrikrrki // LOCUS NP_010830 344 aa linear PLN 30-JUN-2025 DEFINITION carbonyl reductase (NADPH-dependent) [Saccharomyces cerevisiae S288C]. ACCESSION NP_010830 VERSION NP_010830.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180849.4 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12370. On Jul 30, 2012 this sequence version replaced NP_010830.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..344 /product="carbonyl reductase (NADPH-dependent)" /calculated_mol_wt="38455" Region 4..320 /region_name="AR_SDR_e" /note="aldehyde reductase, extended (e) SDRs; cd05227" /db_xref="CDD:187538" Site order(9,11..14,34,60,83..87,127..129,167,171,198..201, 217..218) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:187538" Site order(87,89,129..131,134,167,198..200,221,233,240,310) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:187538" Site order(129,167,171) /site_type="active" /db_xref="CDD:187538" CDS 1..344 /locus_tag="YDR541C" /coded_by="NM_001180849.4:1..1035" /experiment="EXISTENCE:direct assay:GO:0033721 aldehyde dehydrogenase (NADP+) activity [PMID:25656103]" /experiment="EXISTENCE:mutant phenotype:GO:1901426 response to furfural [PMID:25656103]" /note="Aldehyde reductase; substrates include both aromatic and aliphatic aldehydes; uses NADPH as cofactor; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /db_xref="GeneID:852154" /db_xref="SGD:S000002949" ORIGIN 1 msntvlvsga sgfialhils qllkqdykvi gtvrshekea kllrqfqhnp nltleivpdi 61 shpnafdkvl qkrgreiryv lhtaspfhyd tteyekdlli palegtknil nsikkyaadt 121 vervvvtssc taiitlakmd dpsvvftees wneatwescq idginayfas kkfaekaawe 181 ftkenedhik fklttvnpsl lfgpqlfded vhghlntsce minglihtpv nasvpdfhsi 241 fidvrdvala hlyafqkent agkrlvvtng kfgnqdildi lnedfpqlrg liplgkpgtg 301 dqvidrgstt dnsatrkilg fefrslhesv hdtaaqilkk qnrl // LOCUS NP_010831 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010831 VERSION NP_010831.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180850.3 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12371. On Jul 30, 2012 this sequence version replaced NP_010831.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..120 /product="seripauperin PAU10" /calculated_mol_wt="12703" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU10" /locus_tag="YDR542W" /coded_by="NM_001180850.3:1..363" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to the vacuole; member of the seripauperin multigene family encoded mainly in subtelomeric regions" /db_xref="GeneID:852155" /db_xref="SGD:S000002950" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ymfqaahpte 61 typvevaeav fnygdfttml tgiapdqvtr mitgvpwyss rlkpaissal skvgiytian // LOCUS NP_010834 1796 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase protein 1 copy 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010834 VERSION NP_010834.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180853.1 REFERENCE 1 (residues 1 to 1796) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1796) AUTHORS Jacq,C., Alt-Morbe,J., Andre,B., Arnold,W., Bahr,A., Ballesta,J.P., Bargues,M., Baron,L., Becker,A., Biteau,N., Blocker,H., Blugeon,C., Boskovic,J., Brandt,P., Bruckner,M., Buitrago,M.J., Coster,F., Delaveau,T., del Rey,F., Dujon,B., Eide,L.G., Garcia-Cantalejo,J.M., Goffeau,A., Gomez-Peris,A., Zaccaria,P. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IV JOURNAL Nature 387 (6632 SUPPL), 75-78 (1997) PUBMED 9169867 REFERENCE 3 (residues 1 to 1796) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1796) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12372. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1796 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IV" Protein 1..1796 /product="Y' element ATP-dependent helicase protein 1 copy 1" /EC_number="3.6.4.12" /calculated_mol_wt="203651" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 790..962 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" Region 1037..1132 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1796 /gene="YRF1-1" /locus_tag="YDR545W" /gene_synonym="YRF1" /coded_by="NM_001180853.1:1..5391" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9837911]" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:9837911]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]" /note="Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" /db_xref="GeneID:852158" /db_xref="SGD:S000002953" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekivisvmv gknvqkfltf vedepdfqgg pipskylipk kinlmvytlf 121 qvhtlkfnrk dydtlslfyl nrgyynelsf rvlercheia sarpndsstm rtftdfvsga 181 pivrslqkst irkygynlap ymflllhvde lsifsayqas lpgekkvdte rlkrdlcprk 241 pieikyfsqi cndmmnkkdr lgdilhiilr acalnfgagp rggagdeedr sitneepiip 301 svdehglkvc klrspntprr lrktldavka llvsscacta rdldifddtn gvamwkwiki 361 lyhevaqett lkdsyritlv pssdgisvcg klfnreyvrg fyfackaqfd nlwgelnncf 421 ymptvvdias lilrnrevlf repkrgidey lendsflqmi pvkyreivlp klrrdtnkmt 481 aalknkvtva ideltvplmw mvhfavgypy rypelqllaf agpqrnvyvd dttrriqlyt 541 dynkngssep rlktldglts dyvfyfvtvl rqmqicalgn sydafnhdpw mdvvgfedpd 601 qvtnrdisri vlysymflnt akgclveyat frqymrelpk napqklnfre mrqglialgr 661 hcvgsrfetd lyesatselm anhsvqtgrn iygvdsfslt svsgttatll qeraserwiq 721 wlglesdyhc sfsstrnaed vvageaassd hdqkisrvtr krprepkstn dilvagqklf 781 gssfefrdlh qlrlcheiym adtpsvavqa ppgygktelf hlplialask gdvkyvsflf 841 vpytvllanc mirlsrcgcl nvapvrnfie egcdgvtdly vgiyddlast nftdriaawe 901 nivectfrtn nvklgylivd efhnfetevy rqsqfggitn ldfdafekai flsgtapeav 961 adaalqrigl tglakksmdi nelkrsedls rglssyptrm fnlikeksev plghvhkiwk 1021 kvesqpeeal klllalfeie peskaivvas ttneveelac swrkyfrvvw ihgklgaaek 1081 vsrtkefvtd gsmrvligtk lvtegidikq lmmvimldnr lniieliqgv grlrdgglcy 1141 llsrknswaa rnrkgelppi kegciteqvr efygleskkg kkgqhvgccg srtdlsadtv 1201 eliermdrla ekqatasmsi ialpssfqes nssdrcrkyc ssdedsdtci hgsanastna 1261 ttnsstnatt tastnvrtsa tttasinvrt saittestns stnatttast nvrtsattta 1321 sinvrtsatt testnsntsa tttestdsnt satttestds ntsatttast nsstnattta 1381 stnsstnatt testnasake dankdgnaed nrfhpvtdin kesykrkgsq mvllerkklk 1441 aqfpntsenm nvlqflgfrs deikhlflyg idvyfcpegv ftqyglckgc qkmfelcvcw 1501 agqkvsyrrm awealaverm lrndeeykey lediepyhgd pvgylkyfsv krgeiysqiq 1561 rnyawylait rrretisvld strgkqgsqv frmsgrqike lyykvwsnlr esktevlqyf 1621 lnwdekkcre eweakddtvf vealekvgvf qrlrsmtsag lqgpqyvklq fsrhhrqlrs 1681 ryelslgmhl rdqlalgvtp skvphwtafl smliglfynk tfrqkleyll eqisevwllp 1741 hwldlanvev laadntrvpl ymlmvavhke ldsddvpdgr fdiillcrds srevge // LOCUS NP_010835 1277 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010835 VERSION NP_010835.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184302.1 REFERENCE 1 (residues 1 to 1277) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1277) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1277) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1277) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07578. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1277 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1277 /product="Y' element ATP-dependent helicase" /EC_number="3.6.4.12" /calculated_mol_wt="142961" Region 180..>559 /region_name="SSL2" /note="Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; COG1061" /db_xref="CDD:440681" Region 462..557 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" Region 1074..>1127 /region_name="YccJ" /note="YccJ-like protein; cl23921" /db_xref="CDD:451607" CDS 1..1277 /locus_tag="YEL077C" /coded_by="NM_001184302.1:1..3834" /note="Helicase-like protein encoded within the telomeric Y' element" /db_xref="GeneID:856630" /db_xref="SGD:S000006409" ORIGIN 1 mtlgnsydaf nhdpwmdvvg fedpnqvtnr disrivlysy mflntakgcl veyatfrqym 61 relpknapqk lnfremrqgl ialgrhcvgs rfetdlyesa tselmanhsv qtgrniygvd 121 sfsltsvsgt tatllqeras erwiqwlgle sdyhcsfsst rnaedvvage aassdhhqki 181 srvtrkrpre pkstndilva gqklfgssfe frdlhqlrlc yeiymadtps vavqappgyg 241 ktelfhlpli alaskgdvky vsflfvpytv llancmirlg rcgclnvapv rnfieegydg 301 vtdlyvgiyd dlastnftdr iaawenivec tfrtnnvklg ylivdefhnf etevyrqsqf 361 ggitnldfda fekaiflsgt apeavadaal qrigltglak ksmdinelkr sedlsrglss 421 yptrmfnlik eksevplghv hkirkkvesq peealkllla lfesepeska ivvasttnev 481 eelacswrky frvvwihgkl daaekvsrtk efvtdgnmrv ligtklvteg idikqlmmvi 541 mldnrlniie liqgvgrlrd gglcyllsrk nswaarnrkg elppikegci teqvrefygl 601 eskkgkkgqh vgccgsrtdl sadtvelier mdrlaekqat asmsivalps nfqesnssdr 661 yrkycssded sntcihgsan astnastnai ttastnvrtn attnastnat tnastnattn 721 sstnatttas tnvrtsattt asinvrtsat ttestnsstn atttasinvr tsatttksin 781 sstnatites tnsntnattt estnsktsat ttastnsnts atttestnsk tsatttastn 841 sntsatttes tnsntsattt astnsstnat ttestnasak edankdgnae dnrfhpvtdi 901 nkesykrkgs qmvllerkkl kaqfpntsen mnvlqflgfr sdeikhlfly gidiyfcpeg 961 vftqyglckg cqkmfelcvc wagqkvsyrr mawealaver mlrndeeyke ylediepyhg 1021 dpvgylkyfs vkrreiysqi qrnyawylai trrretisvl dstrgkqgsq vfrmsgrqik 1081 elyykvwsnl resktevlqy flnwdekkcq eeweakddtv fvealekvgv fqrlrsmtsa 1141 glqgpqyvkl qfsrhhrqlr sryelslgmh lrdqialgvt pskvphwtaf lsmliglfyn 1201 ktfrqkleyl leqisevwll phwldlanve vlaadntkvp lymlmvavhk eldsddvpdg 1261 rfdiillcrd ssrevge // LOCUS NP_010836 216 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL076C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010836 VERSION NP_010836.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180855.1 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07579. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..216 /product="uncharacterized protein" /calculated_mol_wt="24040" CDS 1..216 /locus_tag="YEL076C-A" /coded_by="NM_001180855.1:1..651" /note="hypothetical protein" /db_xref="GeneID:856632" /db_xref="SGD:S000002955" ORIGIN 1 mqaslpgekk vdterlkrdl cprkpieiky fsqicndmmn kkdrlgdilh iilracalnf 61 gagprggagd eedrsitnee piipsvdehg lkvcklrspn tprrlrktld avkallvssc 121 actardldif ddnngvamwk wikilyheva qettlkdsyr itlvpssdgi sdtltviqsf 181 sysllpvlsa tytsmiqqda snctlittrt vhrsld // LOCUS NP_010837 216 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL076C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010837 VERSION NP_010837.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178891.1 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07580. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..216 /product="uncharacterized protein" /calculated_mol_wt="24334" CDS 1..216 /locus_tag="YEL076C" /coded_by="NM_001178891.1:1..651" /note="hypothetical protein" /db_xref="GeneID:856633" /db_xref="SGD:S000000802" ORIGIN 1 mqaslpgekk vdterlkrdl cprkpieiky fsqicndmmn kkdrlgdilh iilracalnf 61 gagprggagd eedrsitnee piipsvdehg lkvcklrspn tprrlrktld avkallvssc 121 actardldif ddnngvamwk wikilyheva qettlkdsyr itlvpssdgi svcgklwgel 181 nncfhmpasf cviekfcsen rseeltsiwk tilffk // LOCUS NP_010839 122 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL075C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010839 VERSION NP_010839.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178890.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07581. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..122 /product="uncharacterized protein" /calculated_mol_wt="13863" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" CDS 1..122 /locus_tag="YEL075C" /coded_by="NM_001178890.1:1..369" /note="hypothetical protein" /db_xref="GeneID:856634" /db_xref="SGD:S000000801" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekvvisvmv gknvkkfltf vedepdfqgg pipsnkprdg lhvvssayfe 121 iq // LOCUS NP_010841 107 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL073C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010841 VERSION NP_010841.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178888.1 REFERENCE 1 (residues 1 to 107) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 107) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 107) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 107) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07582. Method: conceptual translation. FEATURES Location/Qualifiers source 1..107 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..107 /product="uncharacterized protein" /calculated_mol_wt="11829" CDS 1..107 /locus_tag="YEL073C" /coded_by="NM_001178888.1:1..324" /note="hypothetical protein; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline" /db_xref="GeneID:856636" /db_xref="SGD:S000000799" ORIGIN 1 mvnlanvltn ataatlsaws ntvpletyfh fdeasgfgdy ylnvsviwmn etlyetrivp 61 aiinvrewld hmeandpsps vtnpyetsgy yafstvvpvl mgnmkva // LOCUS NP_010842 231 aa linear PLN 30-JUN-2025 DEFINITION Rmd6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010842 VERSION NP_010842.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178887.1 REFERENCE 1 (residues 1 to 231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 231) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07583. Method: conceptual translation. FEATURES Location/Qualifiers source 1..231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..231 /product="Rmd6p" /calculated_mol_wt="26684" CDS 1..231 /gene="RMD6" /locus_tag="YEL072W" /coded_by="NM_001178887.1:1..696" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /note="Protein required for sporulation; localizes to the peroxisome" /db_xref="GeneID:856637" /db_xref="SGD:S000000798" ORIGIN 1 msacpcnivi lpveilknss kdtkyslytt inrgydvprl kygiivsprv hsletlfsdl 61 gfdkniekss lylllndptl aypnfhehfe qlkgetnkdl slptyyipkv qflteafdse 121 htlatigykp nnkesyeitg ftsmgngygi klfnysvihm mrshkckrvv adiimehdll 181 gyyekklgfv evqrfkvlke qhqvkvfddk vdftkdfhvi kmikelgnhr l // LOCUS NP_010843 496 aa linear PLN 30-JUN-2025 DEFINITION D-lactate dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010843 VERSION NP_010843.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178886.1 REFERENCE 1 (residues 1 to 496) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 496) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 496) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 496) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07584. Method: conceptual translation. FEATURES Location/Qualifiers source 1..496 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..496 /product="D-lactate dehydrogenase" /EC_number="1.1.2.4" /EC_number="1.1.99.40" /calculated_mol_wt="55094" Region 27..494 /region_name="GlcD" /note="FAD/FMN-containing lactate dehydrogenase/glycolate oxidase [Energy production and conversion]; COG0277" /db_xref="CDD:440046" CDS 1..496 /gene="DLD3" /locus_tag="YEL071W" /coded_by="NM_001178886.1:1..1491" /experiment="EXISTENCE:direct assay:GO:0004458 D-lactate dehydrogenase (cytochrome) activity [PMID:10509019]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:10509019]" /experiment="EXISTENCE:direct assay:GO:0071949 FAD binding [PMID:26774271]" /experiment="EXISTENCE:direct assay:GO:0099615 (R)-2-hydroxyglutarate-pyruvate transhydrogenase activity [PMID:26774271]" /experiment="EXISTENCE:mutant phenotype:GO:0019249 lactate biosynthetic process [PMID:26774271]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:16999827]" /experiment="EXISTENCE:mutant phenotype:GO:0099615 (R)-2-hydroxyglutarate-pyruvate transhydrogenase activity [PMID:26774271]" /note="2-hydroxyglutarate transhydrogenase, and minor D-lactate dehydrogenase; converts D-2-hydroxyglutarate (D-2HG), an oncometabolite, to alpha-ketoglutarate in the presence of FAD, with concomitant reduction of pyruvate to D-lactate; minor lactate dehydrogenase activity; component of the retrograde regulon that consists of genes whose expression are stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source; located in the cytoplasm" /db_xref="GeneID:856638" /db_xref="SGD:S000000797" ORIGIN 1 mtaahpvaql taeaypkvkr npnfkvldse dlayfrsils ndeilnsqap eelasfnqdw 61 mkkyrgqsnl illpnstdkv skimkycndk klavvpqggn tdlvgasvpv fdeivlslrn 121 mnkvrdfdpv sgtfkcdagv vmrdahqflh dhdhifpldl psrnncqvgg vvstnaggln 181 flrygslhgn vlglevvlpn geiisninal rkdntgydlk qlfigaegti gvvtgvsiva 241 aakpkalnav ffgienfdtv qklfvkakse lseilsafef mdrgsiecti eylkdlpfpl 301 enqhnfyvli etsgsnkrhd dekltaflkd ttdskliseg mmakdkadfd rlwtwrksvp 361 tacnsyggmy kydmslqlkd lysvsaavte rlnaagligd apkpvvkscg yghvgdgnih 421 lniavreftk qiedllepfv yeyiaskkgs isaehgigfh kkgklhytrs dieirfmkdi 481 knhydpngil npykyi // LOCUS NP_010844 502 aa linear PLN 30-JUN-2025 DEFINITION mannitol dehydrogenase DSF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010844 VERSION NP_010844.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178885.1 REFERENCE 1 (residues 1 to 502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 502) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07585. Method: conceptual translation. FEATURES Location/Qualifiers source 1..502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..502 /product="mannitol dehydrogenase DSF1" /EC_number="1.1.1.67" /calculated_mol_wt="56339" Region 12..500 /region_name="MtlD" /note="Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; COG0246" /db_xref="CDD:440016" CDS 1..502 /gene="DSF1" /locus_tag="YEL070W" /gene_synonym="MAN1" /coded_by="NM_001178885.1:1..1509" /experiment="EXISTENCE:mutant phenotype:GO:0046029 mannitol dehydrogenase activity [PMID:26996892]" /note="Mannitol dehydrogenase; deletion suppresses mutation of mpt5; DSF1 has a paralog, MAN2, that arose from a segmental duplication" /db_xref="GeneID:856639" /db_xref="SGD:S000000796" ORIGIN 1 mtksdettat slnaktlksf estlpiptyp regvkqgivh lgvgafhrsh lavfmhrlmq 61 ehhlkdwsic gvglmkadal mrdamkaqdc lytlvergik dtnayivgsi taymyapddp 121 raviekmanp dthivsltvt engyyhseat nslmtdapei indlnhpekp dtlygylyea 181 lllrykrglt pftimscdnm pqngvtvktm lvafaklkkd ekfaawiedk vtspnsmvdr 241 vtprctdker kyvadtwgik dqcpvvaepf iqwvlednfs dgrppwelvg vqvvkdvdsy 301 elmklrllng ghsamgylgy lagytyihev vndptinkyi rvlmreevip llpkvpgvdf 361 eeytasvler fsnpaiqdtv ariclmgsgk mpkyvlpsiy eqlrkpdgky kllavcvagw 421 fryltgvdmn gkpfeiedpm aptlkaaavk ggkdphelln ievlfspeir dnkefvaqlt 481 hsletvydkg piaaikeild qv // LOCUS NP_010845 564 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010845 VERSION NP_010845.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178884.1 REFERENCE 1 (residues 1 to 564) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 564) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 564) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 564) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07586. Method: conceptual translation. FEATURES Location/Qualifiers source 1..564 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..564 /product="hexose transporter HXT13" /calculated_mol_wt="62603" Region 60..521 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(71,75,202,205..206,209,328..329,333..334,337..338, 363,433..434,437..438,442,465..466,469) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..564 /gene="HXT13" /locus_tag="YEL069C" /gene_synonym="HLT1" /coded_by="NM_001178884.1:1..1695" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015795 sorbitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:genetic interaction:GO:0015797 mannitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by non-fermentable carbon sources; induced in low glucose, repressed in high glucose; HXT13 has a paralog, HXT17, that arose from a segmental duplication" /db_xref="GeneID:856640" /db_xref="SGD:S000000795" ORIGIN 1 mssaqssids dgdvrdadih vappvekews dgfddnevin gdnveppkrg ligylviyll 61 cypisfggfl pgwdsgitag finmdnfkmn fgsykhstge yylsnvrmgl lvamfsigca 121 igglifarla dtlgrrlaiv ivvlvymvga iiqissnhkw yqyfvgkiiy glgaggcsvl 181 cpmllseiap tdlrgglvsl yqlnmtfgif lgycsvygtr kydntaqwrv plglcflwal 241 iiiigmllvp espryliece rheearasia kinkvspedp wvlkqadein agvlaqrelg 301 easwkelfsv ktkvlqrlit gilvqtflql tgenyfffyg ttifksvglt dgfetsivlg 361 tvnffstiia vmvvdkigrr kcllfgaagm macmvifasi gvkclyphgq dgpsskgagn 421 amivftcfyi fcfattwapv ayivvaesfp skvksramsi stacnwlwqf ligfftpfit 481 gsihfyygyv fvgclvamfl yvffflpeti glsleeiqll yeegikpwks aswvppsrrg 541 isseesktek kdwkkflkfs knsd // LOCUS NP_001257672 110 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL068C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257672 VERSION NP_001257672.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270743.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35102. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..110 /product="uncharacterized protein" /calculated_mol_wt="12779" CDS 1..110 /locus_tag="YEL068C" /coded_by="NM_001270743.1:1..333" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; expressed at both mRNA and protein levels; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole" /db_xref="GeneID:856641" /db_xref="SGD:S000000794" ORIGIN 1 mkilalavaf qglalvcctd ttdnynnfth ntstfyriad ydkrfwsvkl ppvnwttcgn 61 edhpwitihy deidklvddk laswdkgpvp dreefrnsil rqarcdrphy // LOCUS NP_010847 195 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL067C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010847 VERSION NP_010847.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178882.1 REFERENCE 1 (residues 1 to 195) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 195) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 195) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 195) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07587. Method: conceptual translation. FEATURES Location/Qualifiers source 1..195 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..195 /product="uncharacterized protein" /calculated_mol_wt="21590" CDS 1..195 /locus_tag="YEL067C" /coded_by="NM_001178882.1:1..588" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:856643" /db_xref="SGD:S000000793" ORIGIN 1 mafttirslt ifsgssfdmp tffvlakggd gsgvffislh ssilyarfpl lnilsqhspv 61 ycsrrfppdn dlitglgnir cgqlvkkalr rvcnvppdhq liasvrsigy arvafvfctc 121 tsecrdnlqs vtrtsghqtt isqpctdiqs trkcstifvs avmqtgtitf fwtfhfpipl 181 qrivnqkqpp pqsyv // LOCUS NP_010848 161 aa linear PLN 30-JUN-2025 DEFINITION D-amino-acid N-acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010848 VERSION NP_010848.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178881.2 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07588. On May 27, 2021 this sequence version replaced NP_010848.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..161 /product="D-amino-acid N-acetyltransferase" /EC_number="2.3.1.36" /calculated_mol_wt="18683" Region 27..149 /region_name="Acetyltransf_1" /note="Acetyltransferase (GNAT) family; pfam00583" /db_xref="CDD:395465" Site order(98..100,110..111) /site_type="other" /note="Coenzyme A binding pocket [chemical binding]" /db_xref="CDD:173926" CDS 1..161 /gene="HPA3" /locus_tag="YEL066W" /coded_by="NM_001178881.2:1..486" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006473 protein acetylation [PMID:23775086]" /experiment="EXISTENCE:direct assay:GO:0008080 N-acetyltransferase activity [PMID:23775086]" /experiment="EXISTENCE:direct assay:GO:0047812 D-amino-acid N-acetyltransferase activity [PMID:15375647]" /experiment="EXISTENCE:mutant phenotype:GO:0046416 D-amino acid metabolic process [PMID:16362288]" /experiment="EXISTENCE:mutant phenotype:GO:0070458 cellular detoxification of nitrogen compound [PMID:16362288|PMID:23775086]" /note="D-Amino acid N-acetyltransferase that detoxifies D-amino acids; catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; acetylates histones and polyamines, also autoacetylates" /db_xref="GeneID:856642" /db_xref="SGD:S000000792" ORIGIN 1 msneepekmv ndrivvkaie pkdeeawnkl wkeyqgfqkt vmppevattt farfidptvk 61 lwgalafdte tgdaigfahy lnhltswhve evvymndlyv terarvkgvg rkliefvysr 121 adelgtpavy wvtdhynhra qllytkvayk tdkvlykrng y // LOCUS NP_010849 628 aa linear PLN 30-JUN-2025 DEFINITION siderophore transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_010849 VERSION NP_010849.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178880.3 REFERENCE 1 (residues 1 to 628) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 628) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 628) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 628) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07589. On Jul 30, 2012 this sequence version replaced NP_010849.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..628 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..628 /product="siderophore transporter" /calculated_mol_wt="70431" Region 70..582 /region_name="MFS_ARN_like" /note="Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; cd17322" /db_xref="CDD:340880" Site order(84..85,88..89,92,123,173..174,176..178,181,197, 200..201,204,362,365..366,369..371,374,402,406,460..461, 465,469,486,489..490,493..494,497) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340880" CDS 1..628 /gene="SIT1" /locus_tag="YEL065W" /gene_synonym="ARN3" /coded_by="NM_001178880.3:1..1887" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:19469713]" /experiment="EXISTENCE:direct assay:GO:0006879 intracellular iron ion homeostasis [PMID:9884238]" /experiment="EXISTENCE:direct assay:GO:0031410 cytoplasmic vesicle [PMID:10748025]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9884238]" /experiment="EXISTENCE:mutant phenotype:GO:0015344 siderophore uptake transmembrane transporter activity [PMID:9884238]" /experiment="EXISTENCE:mutant phenotype:GO:0015891 siderophore transport [PMID:9884238]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:9884238]" /note="Ferrioxamine B transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p" /db_xref="GeneID:856644" /db_xref="SGD:S000000791" ORIGIN 1 mdpgianhtl peefeevvvp emlekevgak vdvkptltts spapsyieli dpgvhnieiy 61 aemynrpiyr valffslfli ayaygldgni rytfqayats sysqhsllst vnciktviaa 121 vgqiffarls difgrfsimi vsiifysmgt iiesqavnit rfavggcfyq lgltgiilil 181 eviasdfsnl nwrllalfip alpfiintwi sgnvtsaida nwkwgigmwa filplacipl 241 gicmlhmryl arkhakdrlk pefealnklk wksfcidiaf wkldiigmll itvffgcvlv 301 pftlagglke ewktahiivp evigwvvvlp lymlweikys rhpltpwdli qdrgiffall 361 iaffinfnwy mqgdymytvl vvavhesiks atritslysf vsvivgtilg filikvrrtk 421 pfiifgiscw ivsfgllvhy rgdsgahsgi igslcllgfg agsftyvtqa siqasaktha 481 rmavvtslyl atynigsafg ssvsgavwtn ilpkeiskri sdptlaaqay gspftfitty 541 twgtperial vmsyryvqki lciiglvfcf pllgcafmlr nhkltdsial egndhleskn 601 tfeieekees flknkffthf tsskdrkd // LOCUS NP_010850 480 aa linear PLN 30-JUN-2025 DEFINITION Avt2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010850 VERSION NP_010850.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178879.1 REFERENCE 1 (residues 1 to 480) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 480) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 480) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 480) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07590. Method: conceptual translation. FEATURES Location/Qualifiers source 1..480 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..480 /product="Avt2p" /calculated_mol_wt="53193" Region 65..467 /region_name="Aa_trans" /note="Transmembrane amino acid transporter protein; pfam01490" /db_xref="CDD:279788" CDS 1..480 /gene="AVT2" /locus_tag="YEL064C" /coded_by="NM_001178879.1:1..1443" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11274162]" /note="Putative transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" /db_xref="GeneID:856645" /db_xref="SGD:S000000790" ORIGIN 1 mselgeyskl enkelrtefe ltnfpfpgtt dndsddgsqg qnslniitpd mddtlvndvl 61 rendkkssmr mafmnlansi lgagiitqpf aiknagilgg llsyvalgfi vdwtlrlivi 121 nltlagkrty qgtvehvmgk kgkllilftn glfafggcig yciiigdtip hvlraifsqn 181 dgnvhfwlrr nviivmvttf isfplsmkrn iealskasfl avismiiivl tvvirgpmlp 241 ydwkghslkl sdffmkatif rslsvisfal vchhntsfif fsmrnrsvak ftrlthisii 301 isviccalmg ysgfavfkek tkgnvlnsfp gtdtainiar lcfgfnmltt fpmeifvlrd 361 vvgnllhecn liknydehtq lsgkqhvvit sslvfitmgi slttcnlgal feligattas 421 tmayilppyt nllltskkks wkerlpfylc icfgfmimii sstqtiidav ngsdgqhcqi // LOCUS NP_010851 590 aa linear PLN 30-JUN-2025 DEFINITION arginine permease CAN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010851 VERSION NP_010851.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178878.1 REFERENCE 1 (residues 1 to 590) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 590) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 590) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 590) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07591. Method: conceptual translation. FEATURES Location/Qualifiers source 1..590 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..590 /product="arginine permease CAN1" /calculated_mol_wt="65655" Region 85..562 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..590 /gene="CAN1" /locus_tag="YEL063C" /coded_by="NM_001178878.1:1..1773" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15536122]" /experiment="EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015802 basic amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:15536122|PMID:29402931]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:10654085]" /experiment="EXISTENCE:genetic interaction:GO:1903826 L-arginine transmembrane transport [PMID:23047103]" /experiment="EXISTENCE:mutant phenotype:GO:0061459 L-arginine transmembrane transporter activity [PMID:10753927]" /note="Plasma membrane arginine permease; transceptor that senses extracellular basic amino acids; negative regulator of biofilm formation; requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance; CAN1 has a paralog, ALP1, that arose from the whole genome duplication" /db_xref="GeneID:856646" /db_xref="SGD:S000000789" ORIGIN 1 mtnskedadi eekhmynepv ttlfhdveas qthhrrgsip lkdekskely plrsfptrvn 61 gedtfsmedg igdedegevq naevkrelkq rhigmialgg tigtglfigl stpltnagpv 121 galisylfmg slaysvtqsl gematfipvt ssftvfsqrf lspafgaang ymywfswait 181 falelsvvgq viqfwtykvp laawisifwv iitimnlfpv kyygefefwv asikvlaiig 241 fliycfcmvc gagvtgpvgf rywrnpgawg pgiiskdkne grflgwvssl inaaftfqgt 301 elvgitagea anprksvpra ikkvvfrilt fyigsllfig llvpyndpkl tqstsyvsts 361 pfiiaiensg tkvlphifna vilttiisaa nsniyvgsri lfglsknkla pkflsrttkg 421 gvpyiavfvt aafgalayme tstggdkvfe wllnitgvag ffawlfisis hirfmqalky 481 rgisrdelpf kaklmpglay yaatfmtiii iiqgftafap kfngvsfaaa yisiflflav 541 wilfqcifrc rfiwkigdvd idsdrrdiea ivwedhepkt fwdkfwnvva // LOCUS NP_010852 615 aa linear PLN 30-JUN-2025 DEFINITION nitrogen permease regulating protein NPR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010852 VERSION NP_010852.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178877.3 REFERENCE 1 (residues 1 to 615) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 615) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 615) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 615) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07592. On Jul 30, 2012 this sequence version replaced NP_010852.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..615 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..615 /product="nitrogen permease regulating protein NPR2" /calculated_mol_wt="69728" Region 9..490 /region_name="NPR3" /note="Nitrogen Permease regulator of amino acid transport activity 3; cl24021" /db_xref="CDD:451662" CDS 1..615 /gene="NPR2" /locus_tag="YEL062W" /coded_by="NM_001178877.3:1..1848" /experiment="EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]" /experiment="EXISTENCE:direct assay:GO:1990130 GATOR1 complex [PMID:21900499]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:25046117]" /experiment="EXISTENCE:genetic interaction:GO:0010508 positive regulation of autophagy [PMID:25046117]" /experiment="EXISTENCE:genetic interaction:GO:1904262 negative regulation of TORC1 signaling [PMID:23716719|PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:12869630]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0015824 proline transport [PMID:7867803]" /experiment="EXISTENCE:mutant phenotype:GO:0015840 urea transport [PMID:7867803]" /experiment="EXISTENCE:mutant phenotype:GO:0034198 cellular response to amino acid starvation [PMID:19521502]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:19521502|PMID:25046117|PMID:23716719]" /experiment="EXISTENCE:mutant phenotype:GO:2000785 regulation of autophagosome assembly [PMID:21900499]" /note="Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of the SEA complex, a coatomer-related complex that associates dynamically with the vacuole; Npr2p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and resulting in inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; homolog of human tumor suppressor NPRL2" /db_xref="GeneID:856647" /db_xref="SGD:S000000788" ORIGIN 1 mlsyfqgfvp ihtifysvfh ptegskikye fppnnlknhg infntfknyi ipkpilchkl 61 itfkygtyri vcypvtinsp iyarnffsfn fvfvfpydce tspyepaitr lgkmfkvlee 121 qnqllskser dpvffdlkvl enstttpsta gpsstpnpss nttpthptse kdtkdmrssr 181 ysdlikdlgl pqsafsiqdl lmrifqdlnn yseclipide gnavdikifp llrppttcvs 241 ledvplssvn lkkiidvnwd ptmmsivpyi dglnsiakis klsnsdpglv iecirhliyy 301 kcvtlsdifq fsniyapssl irnfltdplm asdcqsyvtf pevskisnlp lnkslgsgdq 361 dspsfsvrrk sksssipsnp dsrttsfsst srvsqnssln ssfssiykdw rqsqtscsss 421 nihvinnrnr flptrsclfd lyrslsqgqt lktwyeskym ilkennidir rfitfglekr 481 iiyrcysfpv minagsrepk emtpiitkdl vnndkllekr nhnhllsatg srntaqsgnl 541 kperpskvsf emqrvsslat gkstmpklsd eeegileesi rnaetfdkic vllskpklev 601 esylnelgef kvins // LOCUS NP_010853 1000 aa linear PLN 30-JUN-2025 DEFINITION kinesin motor protein CIN8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010853 VERSION NP_010853.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178876.1 REFERENCE 1 (residues 1 to 1000) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1000) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1000) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1000) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1000) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1000) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1000) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1000) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1000) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07593. On Oct 2, 2003 this sequence version replaced NP_010853.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1000 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1000 /product="kinesin motor protein CIN8" /calculated_mol_wt="113180" Region 34..486 /region_name="KISc_BimC_Eg5" /note="Kinesin motor domain, BimC/Eg5 spindle pole proteins; cd01364" /db_xref="CDD:276815" Site order(44,128,131,133..136,383) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:276815" Site order(430,433,436) /site_type="other" /note="microtubule interaction site [polypeptide binding]" /db_xref="CDD:276815" Region <520..978 /region_name="235kDa-fam" /note="reticulocyte binding/rhoptry protein; TIGR01612" /db_xref="CDD:130673" CDS 1..1000 /gene="CIN8" /locus_tag="YEL061C" /gene_synonym="KSL2; SDS15" /coded_by="NM_001178876.1:1..3003" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11511347]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005828 kinetochore microtubule [PMID:19041752]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:1618897|PMID:11511347]" /experiment="EXISTENCE:direct assay:GO:0008569 minus-end-directed microtubule motor activity [PMID:21350123]" /experiment="EXISTENCE:direct assay:GO:0008574 plus-end-directed microtubule motor activity [PMID:21350123]" /experiment="EXISTENCE:direct assay:GO:0033047 regulation of mitotic sister chromatid segregation [PMID:31253793]" /experiment="EXISTENCE:direct assay:GO:1990023 mitotic spindle midzone [PMID:16533946]" /experiment="EXISTENCE:genetic interaction:GO:0000070 mitotic sister chromatid segregation [PMID:7860634]" /experiment="EXISTENCE:genetic interaction:GO:0000073 initial mitotic spindle pole body separation [PMID:1618897|PMID:1618910]" /experiment="EXISTENCE:genetic interaction:GO:0000089 mitotic metaphase [PMID:16533946]" /experiment="EXISTENCE:genetic interaction:GO:0003777 microtubule motor activity [PMID:1618910]" /experiment="EXISTENCE:genetic interaction:GO:0098653 centromere clustering [PMID:16533946]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:23851487|PMID:9813090]" /experiment="EXISTENCE:mutant phenotype:GO:0000073 initial mitotic spindle pole body separation [PMID:1618897]" /experiment="EXISTENCE:mutant phenotype:GO:0000089 mitotic metaphase [PMID:16533946]" /experiment="EXISTENCE:mutant phenotype:GO:0000235 astral microtubule [PMID:19041752]" /experiment="EXISTENCE:mutant phenotype:GO:0007019 microtubule depolymerization [PMID:19041752]" /experiment="EXISTENCE:mutant phenotype:GO:0008569 minus-end-directed microtubule motor activity [PMID:27216310]" /experiment="EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:31964755]" /experiment="EXISTENCE:mutant phenotype:GO:0090307 mitotic spindle assembly [PMID:9813090|PMID:23851487]" /experiment="EXISTENCE:mutant phenotype:GO:0098653 centromere clustering [PMID:16533946]" /note="Bipolar kinesin motor protein; switches from minus- to plus-end-directed motility in vitro depending on conditions; involved in mitotic spindle assembly, chromosome segregation and centromere clustering on the metaphase spindle" /db_xref="GeneID:856648" /db_xref="SGD:S000000787" ORIGIN 1 mpaenqntgq drssnsiskn gnsqvgchtv pneelnitva vrcrgrnere ismkssvvvn 61 vpditgskei sinttgdtgi taqmnakryt vdkvfgpgas qdlifdevag plfqdfikgy 121 nctvlvygmt stgktytmtg deklyngels daagiiprvl lklfdtlelq qndyvvkcsf 181 ielyneelkd lldsnsngss ntgfdgqfmk klrifdssta nnttsnsass srsnsrnssp 241 rslndltpka allrkrlrtk slpntikqqy qqqqavnsrn nsssnsgstt nnassntntn 301 ngqrssmapn dqtngiyiqn lqefhitnam eglnllqkgl khrqvastkm ndfssrshti 361 ftitlykkhq delfriskmn lvdlagseni nrsgalnqra keagsinqsl ltlgrvinal 421 vdksghipfr eskltrllqd slggntktal iatispakvt seetcstley askakniknk 481 pqlgsfimkd ilvknitmel akiksdllst kskegiymsq dhyknlnsdl esyknevqec 541 kreiesltsk nallvkdklk sketiqsqnc qieslkttid hlraqldkqh kteieisdfn 601 nklqkltevm qmalhdykkr eldlnqkfem hitkeikklk stlflqlntm qqesilqetn 661 iqpnldmikn evltlmrtmq ekaelmykdc vkkilnespk ffnvviekid iirvdfqkfy 721 kniaenlsdi seennnmkqy lknhffknnh qellnrhvds tyeniekrtn efvenfkkvl 781 ndhldenkkl imqnlttats avidqemdlf epkrvkwens fdlindcdsm nnefynsmaa 841 tlsqikstvd tssnsmnesi svmkgqvees enaisllknn tkfndqfeql inkhnmlkdn 901 iknsitsths hitnvddiyn tienimknyg nkenatkdem ienilkeipn lskkmplrls 961 ninsnsvqsv ispkkhaied enkssenvdn egsrkmlkie // LOCUS NP_010854 635 aa linear PLN 30-JUN-2025 DEFINITION proteinase B [Saccharomyces cerevisiae S288C]. ACCESSION NP_010854 VERSION NP_010854.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178875.1 REFERENCE 1 (residues 1 to 635) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 635) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 635) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 635) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07594. Method: conceptual translation. FEATURES Location/Qualifiers source 1..635 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..635 /product="proteinase B" /EC_number="3.4.21.48" /calculated_mol_wt="69491" Region 182..278 /region_name="Inhibitor_I9" /note="Peptidase inhibitor I9; pfam05922" /db_xref="CDD:428674" Region 290..566 /region_name="Peptidases_S8_PCSK9_ProteinaseK_like" /note="Peptidase S8 family domain in ProteinaseK-like proteins; cd04077" /db_xref="CDD:173790" Site order(293,296..297) /site_type="other" /note="calcium binding site 2 [ion binding]" /db_xref="CDD:173790" Site order(325,357,426..427,454,516,519) /site_type="active" /db_xref="CDD:173790" Site order(325,357,519) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:173790" Site order(468,470,493) /site_type="other" /note="calcium binding site 1 [ion binding]" /db_xref="CDD:173790" CDS 1..635 /gene="PRB1" /locus_tag="YEL060C" /gene_synonym="CVT1" /coded_by="NM_001178875.1:1..1908" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:31332264]" /experiment="EXISTENCE:mutant phenotype:GO:0004252 serine-type endopeptidase activity [PMID:377296|PMID:385314]" /experiment="EXISTENCE:mutant phenotype:GO:0007039 protein catabolic process in the vacuole [PMID:2674123|PMID:385314]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:2674123]" /note="Vacuolar proteinase B yscB with H3 N-terminal endopeptidase activity; serine protease of subtilisin family; involved in protein degradation in vacuole; required for full protein degradation during sporulation; activity inhibited by Pbi2p; protein abundance increases in response to DNA replication stress; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via AP-3 pathway; PRB1 has a paralog, YSP3, that arose from the whole genome duplication" /db_xref="GeneID:856649" /db_xref="SGD:S000000786" ORIGIN 1 mklentlftl galgsisaal vipnlenaad hhelinkedh herprkveft kdddeepsds 61 edkehgkfhk kgrkgqdkes pefngkrasg shgsaheggk gmkpkhessn dddnddkkkk 121 phhkggchen kveekkmkgk kvkgkkhhek tlekgrhhnr laplvstaqf npdaiskiip 181 nryiivfkrg apqeeidfhk envqqaqlqs venlsaedaf fistkdtsls tseaggiqds 241 fnidnlfsgy igyftqeivd lirqnplvdf verdsiveat efdtqnsapw glarishrer 301 lnlgsfnkyl ydddagrgvt syvidtgvni nhkdfekrai wgktiplnde dldgnghgth 361 cagtiaskhy gvaknanvva vkvlrsngsg tmsdvvkgve yaakahqkea qekkkgfkgs 421 tanmslgggk spaldlavna avevgihfav aagnenqdac ntspasadka itvgastlsd 481 drayfsnwgk cvdvfapgln ilstyigsdd atatlsgtsm asphvagllt yflslqpgsd 541 seffelgqds ltpqqlkkkl ihystkdilf dipedtpnvl iyngggqdls afwndtkksh 601 ssgfkqelnm defigsktdl ifdqvrdild klnii // LOCUS NP_058154 74 aa linear PLN 30-JUN-2025 DEFINITION Som1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_058154 VERSION NP_058154.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180854.3 REFERENCE 1 (residues 1 to 74) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 74) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 74) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 74) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07595. On Jul 30, 2012 this sequence version replaced NP_058154.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..74 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..74 /product="Som1p" /calculated_mol_wt="8284" Region 1..69 /region_name="Mitochondr_Som1" /note="Mitochondrial export protein Som1; pfam11093" /db_xref="CDD:402600" CDS 1..74 /gene="SOM1" /locus_tag="YEL059C-A" /coded_by="NM_001180854.3:1..225" /experiment="EXISTENCE:curator inference:GO:0004175 endopeptidase activity [PMID:10821182]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9604886]" /experiment="EXISTENCE:mutant phenotype:GO:0033108 mitochondrial respiratory chain complex assembly [PMID:19703468]" /experiment="EXISTENCE:physical interaction:GO:0042720 mitochondrial inner membrane peptidase complex [PMID:10821182]" /note="Subunit of the mitochondrial inner membrane peptidase (IMP); IMP is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs" /db_xref="GeneID:856650" /db_xref="SGD:S000002954" ORIGIN 1 mappttirtr dqalaplatl dsqtncrlke lvqwecqfkg aeyvcspfkr lfehciapdk 61 satnyevtdt ytns // LOCUS NP_001381963 102 aa linear PLN 30-JUN-2025 DEFINITION Hhy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381963 VERSION NP_001381963.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395033.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54804. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..102 /product="Hhy1p" /calculated_mol_wt="11210" CDS 1..102 /gene="HHY1" /locus_tag="YEL059W" /coded_by="NM_001395033.1:1..309" /note="hypothetical protein; null mutant is sensitive to heat, pH disturbances, ionic stress, and various chemicals; hypersensitivity to hygromycin B indicative of defects in vacuolar trafficking" /db_xref="GeneID:856651" /db_xref="SGD:S000000785" ORIGIN 1 mslsfllfsp flppcfssis iclsvlstvs fffaftiphy vlrcgsvdew hihssaedfr 61 tqrcvcavkl sasllgclla caswslllev srikwhvgta ys // LOCUS NP_010856 557 aa linear PLN 30-JUN-2025 DEFINITION phosphoacetylglucosamine mutase PCM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010856 VERSION NP_010856.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178873.1 REFERENCE 1 (residues 1 to 557) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 557) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 557) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 557) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07596. Method: conceptual translation. FEATURES Location/Qualifiers source 1..557 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..557 /product="phosphoacetylglucosamine mutase PCM1" /EC_number="5.4.2.3" /calculated_mol_wt="61936" Region 24..553 /region_name="PGM3" /note="PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into...; cd03086" /db_xref="CDD:100088" Site order(31,67..68,298,300,302..303,375..377,395,397,399,522, 524..526,531) /site_type="active" /db_xref="CDD:100088" Site order(298,300,302) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:100088" Site order(375..377,395,397,399,522,524..526,531) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:100088" CDS 1..557 /gene="PCM1" /locus_tag="YEL058W" /gene_synonym="AGM1" /coded_by="NM_001178873.1:1..1674" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004610 phosphoacetylglucosamine mutase activity [PMID:8174553]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:8174553]" /note="Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors" /db_xref="GeneID:856652" /db_xref="SGD:S000000784" ORIGIN 1 mkvdyeqlck lyddtcrtkn vqfsygtagf rtlaknldtv mfstgilavl rslklqgqyv 61 gvmitashnp yqdngvkive pdgsmllatw epyamqlana asfatnfeef rvelaklieh 121 ekidlnttvv phivvgrdsr esspyllrcl tssmasvfha qvldlgcvtt pqlhyitdls 181 nrrklegdta pvateqdyys ffigafnelf atyqlekrls vpklfidtan giggpqlkkl 241 lasedwdvpa eqvevindrs dvpellnfec gadyvktnqr lpkglspssf dslycsfdgd 301 adrvvfyyvd sgskfhlldg dkistlfakf lskqlelahl ehslkigvvq tayangssta 361 yikntlhcpv sctktgvkhl hheaatqydi giyfeanghg tiifsekfhr tikselsksk 421 lngdtlalrt lkcfselinq tvgdaisdml avlatlailk mspmdwdeey tdlpnklvkc 481 ivpdrsifqt tdqerkllnp vglqdkidlv vakypmgrsf vrasgtedav rvyaeckdss 541 klgqfcdevv ehvkasa // LOCUS NP_010857 233 aa linear PLN 30-JUN-2025 DEFINITION Sdd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010857 VERSION NP_010857.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178872.1 REFERENCE 1 (residues 1 to 233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 233) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07597. Method: conceptual translation. FEATURES Location/Qualifiers source 1..233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..233 /product="Sdd1p" /calculated_mol_wt="27097" CDS 1..233 /gene="SDD1" /locus_tag="YEL057C" /coded_by="NM_001178872.1:1..702" /note="hypothetical protein; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; may have a role in telomere maintenance; target of UME6 regulation" /db_xref="GeneID:856653" /db_xref="SGD:S000000783" ORIGIN 1 mandgiqrnd nrkgfktvqf sayskeidvi mkkisflern itqqldtlph fpktlppnhk 61 dcvsrkhrar rgwssqlknl lgiyskeeif tldnlaatlh dqvlklqatl fpnailkqvh 121 ldnanienkr ilkeitykyl snenckeenk fgtfivkrif fgdlslgvsv linriafesa 181 tssimvvrss fiesdffyed ylifdcrakr rkklkrkilf isttmnfnyq tkv // LOCUS NP_010858 401 aa linear PLN 30-JUN-2025 DEFINITION Hat2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010858 VERSION NP_010858.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178871.3 REFERENCE 1 (residues 1 to 401) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 401) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 401) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 401) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07598. On Jul 30, 2012 this sequence version replaced NP_010858.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..401 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..401 /product="Hat2p" /calculated_mol_wt="44929" Region 12..82 /region_name="CAF1C_H4-bd" /note="Histone-binding protein RBBP4 or subunit C of CAF1 complex; pfam12265" /db_xref="CDD:463513" Region <117..380 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 122..158 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 163..204 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 212..247 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 254..292 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 298..349 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 355..380 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..401 /gene="HAT2" /locus_tag="YEL056W" /coded_by="NM_001178871.3:1..1206" /experiment="EXISTENCE:direct assay:GO:0000123 histone acetyltransferase complex [PMID:9575221|PMID:8858151]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:8858151]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9575221|PMID:14761951]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8858151|PMID:9575221]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:8858151]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:8858151]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:10982821]" /experiment="EXISTENCE:mutant phenotype:GO:0004402 histone acetyltransferase activity [PMID:8858151|PMID:9575221]" /experiment="EXISTENCE:physical interaction:GO:0000123 histone acetyltransferase complex [PMID:8858151]" /note="Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing" /db_xref="GeneID:856654" /db_xref="SGD:S000000782" ORIGIN 1 menqekplsv deeydlwksn vplmydfvse trltwpsltv qwlptpvqel dggfikqeli 61 igthtsgeee nylkfaeinl pkeilsnedp qeeageeyqs slpaprsnir itakyeheee 121 itrarympqd pnivatingq gtvflysrse glqstlkfhk dngyalsfst lvkgrllsgs 181 ddhtvalwev gsggdptkpv rtwndlhsdi indnkwhnfn kdlfgtvsed sllkindvra 241 nnttidtvkc pqpfntlafs hhssnllaaa gmdsyvylyd lrnmkeplhh msghedavnn 301 lefsthvdgv vvssgsdnrl mmwdlkqiga eqtpddaedg vpelimvhag hrssvndfdl 361 npqipwlvas aeeenilqvw kcshslpivg gppkvnkdii s // LOCUS NP_010859 1022 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed DNA polymerase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010859 VERSION NP_010859.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178870.1 REFERENCE 1 (residues 1 to 1022) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1022) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1022) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1022) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1022) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1022) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1022) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1022) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1022) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07599. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1022 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1022 /product="DNA-directed DNA polymerase" /EC_number="2.7.7.7" /calculated_mol_wt="115764" Region 46..859 /region_name="DNA_pol_phi" /note="DNA polymerase phi; pfam04931" /db_xref="CDD:461488" CDS 1..1022 /gene="POL5" /locus_tag="YEL055C" /coded_by="NM_001178870.1:1..3069" /experiment="EXISTENCE:direct assay:GO:0000027 ribosomal large subunit assembly [PMID:31745560]" /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:12093911]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12093911|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:31745560]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:31745560|PMID:31413149]" /experiment="EXISTENCE:direct assay:GO:0090070 positive regulation of ribosome biogenesis [PMID:31745560]" /experiment="EXISTENCE:mutant phenotype:GO:0009303 rRNA transcription [PMID:12093911]" /experiment="EXISTENCE:mutant phenotype:GO:0090070 positive regulation of ribosome biogenesis [PMID:31413149]" /note="Protein involved in 60S assembly and pre-40S AFs recycling; has sequence similarity to human MybBP1A and weak sequence similarity to B-type DNA polymerases; not required for chromosomal DNA replication" /db_xref="GeneID:856655" /db_xref="SGD:S000000781" ORIGIN 1 mtgkvnrdlf fklasdlree rlhaavalik dlsaldlpdd aeewsyvlnr likglssdrn 61 sarlgfslcl tevinlavnm ppgqrpkgle stneflstls tilnvnvneg tkksmkgkde 121 rgilfgklfg lksllneplf seifvkdlek gnteffirft eqlidlalkk nwikepcfft 181 lfqtmkmllp fmdessaeki lliydkydlt ltneglstyl llkyegdesl ipsvldlknp 241 gwkdndplar gnlplltkvl rnssvipdan gglketkkqk ntnwnprlhf vwsvllplfg 301 ngklentshi skkrkktnnk kvqnsiqfpe fwkmavdesf fnekasserk ylgfliidaa 361 fkavpgsyig fcfsqnvmrt linqsidsqr vlnkisqltl dsivkaceed sanrlvpcln 421 amlfgphgsi nfdkltksgt vskliaikel pstvlaqlld vfflqlqdkk gvlshtlfal 481 dsilhivrah kveindmdim kpvlrpivym affkhtsddl kleqlhelak erlysilgel 541 tinkeirckd peinswqylt lklildiens hvgdlinpld enleniknea isclskvcrs 601 rtaqswglst llsmclvqly agdtdsisvi eelcefskhe nnsmvgitei llsllaqkka 661 llrklsliiw qqfieevgle elqilldilk arenkqgfaq lfegeeefee ikeendased 721 esktgseses esesdsddad ekdeedeane dilnidkeat salvkalnlp dnivndkgev 781 dldqleglsd dggddedees mddekmmeld dqlseifkrr kealssistg nqrkfevkqs 841 renvisfkhr vvdmlavyvk ycekltlank sehsnnlggs lsklvyfiip mlkcvnetld 901 rpladkiskl lkgkifkikv tafkdmnkdi elmdllkkth klmltskpgq haavfysmcs 961 tsslflskly veiggndkld elidlytatt kewmqkgkcg pnifidfinw lsskkqtvmd 1021 ke // LOCUS NP_010860 165 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL11 RPL12A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010860 VERSION NP_010860.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178869.1 REFERENCE 1 (residues 1 to 165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 165) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07600. Method: conceptual translation. FEATURES Location/Qualifiers source 1..165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..165 /product="60S ribosomal protein uL11 RPL12A" /calculated_mol_wt="17692" Region 1..165 /region_name="PLN03072" /note="60S ribosomal protein L12; Provisional" /db_xref="CDD:178621" CDS 1..165 /gene="RPL12A" /locus_tag="YEL054C" /coded_by="NM_001178869.1:1..498" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:genetic interaction:GO:0034517 ribophagy [PMID:39934334]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:9822666]" /note="Ribosomal 60S subunit protein L12A functions as a ribophagy receptor; phosphorylation by Atg1p triggers ribophagy during starvation; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to human RPL12, Drosophila rpl12, and C. elegans ppl-12 that all function as conserved ribophagy receptors; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication" /db_xref="GeneID:856656" /db_xref="SGD:S000000780" ORIGIN 1 mppkfdpnev kylylravgg evgasaalap kigplglspk kvgediakat kefkgikvtv 61 qlkiqnrqaa asvvpsassl vitalkeppr drkkdknvkh sgniqldeii eiarqmrdks 121 fgrtlasvtk eilgtaqsvg crvdfknphd iieginagei eipen // LOCUS NP_010861 733 aa linear PLN 30-JUN-2025 DEFINITION Mak10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010861 VERSION NP_010861.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178868.3 REFERENCE 1 (residues 1 to 733) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 733) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 733) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 733) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07601. On Jul 30, 2012 this sequence version replaced NP_010861.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..733 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..733 /product="Mak10p" /calculated_mol_wt="84172" Region 35..193 /region_name="Mak10" /note="Mak10 subunit, NatC N(alpha)-terminal acetyltransferase; pfam04112" /db_xref="CDD:461179" CDS 1..733 /gene="MAK10" /locus_tag="YEL053C" /gene_synonym="NAA35" /coded_by="NM_001178868.3:1..2202" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031417 NatC complex [PMID:10504710]" /experiment="EXISTENCE:mutant phenotype:GO:0004596 protein-N-terminal amino-acid acetyltransferase activity [PMID:11274203]" /experiment="EXISTENCE:mutant phenotype:GO:0006474 N-terminal protein amino acid acetylation [PMID:11274203]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /note="Non-catalytic subunit of the NatC N-terminal acetyltransferase; required for replication of dsRNA virus; expression is glucose-repressible; human NatC ortholog, Naa35, requires co-expression of the human catalytic subunit, Naa30, to functionally complement the null allele" /db_xref="GeneID:856657" /db_xref="SGD:S000000779" ORIGIN 1 mevdsilgsl sitddfdqlv dvtslfdelc sklkpeaivk dprfdlfegt hslevnnskl 61 dsslieltae eiefdvnvay dpplasvaai adrllrcvis wlndyqtlpt tvlscrytes 121 llsslvkgtt agsswctgni lydkvlgsci lgvcyltkfv qkllsagivf eeedlnfnnm 181 gfntfdnlpg qdvvinslte slqileaysd dslhltmlkh ilkiiiclvh ledhltdyst 241 ktshldelie nansvngifp qlqlsppkga fstyiqkhrs nqfpprkitk lptdysgfit 301 landvktill vdkaesalet yqfakffnkl eqrhviaril fplffirddr tvlgkfsytq 361 fyllhvkefs aqtpsefess igneliqess nmllewyqnc sqntcryrqg fnrqlilwds 421 lqaqfesvns qvycswtyfm klssmiefsl kgfdldiykp feaysmfwyv yylshhletf 481 lkdsqndies ninaihsmnk klkklkagek kdqlrlkyrf amdnemeqlq atkqflnyll 541 keinitkslc lievfqfail ksfglidnkn stpskfsner lihnlrfkpf nsigvpelpe 601 yevfqqtlkd fvieekgaaf dikleratnf ietevrnvvs sideimqgik ggdnngvlvt 661 gtrlvqelsl eyycklkhts kalsvnskvi vntlkknikn kdsheykvel vhttegwnyf 721 piqtlrikqd ryk // LOCUS NP_010862 509 aa linear PLN 30-JUN-2025 DEFINITION Afg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010862 VERSION NP_010862.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178867.1 REFERENCE 1 (residues 1 to 509) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 509) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 509) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 509) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 509) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 509) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 509) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 509) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 509) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07602. Method: conceptual translation. FEATURES Location/Qualifiers source 1..509 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..509 /product="Afg1p" /calculated_mol_wt="58134" Region 34..507 /region_name="ZapE" /note="Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, cell division, chromosome partitioning]; COG1485" /db_xref="CDD:441094" CDS 1..509 /gene="AFG1" /locus_tag="YEL052W" /coded_by="NM_001178867.1:1..1530" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:17430883]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17430883]" /experiment="EXISTENCE:mutant phenotype:GO:0141164 mitochondrial protein quality control [PMID:17430883]" /note="Protein that may act as a chaperone for cytochrome c oxidase subunits; conserved protein; may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain" /db_xref="GeneID:856658" /db_xref="SGD:S000000778" ORIGIN 1 mialkpnavr tfrqvqhcsf ricryqstks nkcltplqey drlvklgklr ddtyqrgiis 61 slgdlydslv kyvppvvktp navdqvggwl nglksvfsrg kpknigayvd vskignsipr 121 gvylygdvgc gktmlmdlfy ttipnhltkk rihfhqfmqy vhkrsheivr eqnlkelgda 181 kgkeidtvpf laaeiannsh vlcfdefqvt dvadamilrr lmtallsddy gvvlfatsnr 241 hpdelyingv qrqsfipcie likhrtkvif lnsptdyrki prpvssvyyf psdtsikyas 301 kecktrreth ikewynyfaq ashtddstds htvhktfydy pltiwgrefk vpkctpprva 361 qftfkqlcge plaagdyltl aknfeafivt dipylsiyvr devrrfitfl davydsggkl 421 attgaadfss lfvepeqiln dfelrpttke pdsvdtgmvd emvekhgfsk eiakksqmfa 481 ldeerfafar alsrlsqmss tdwvtkpty // LOCUS NP_010863 256 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V1 sector ATPase subunit D [Saccharomyces cerevisiae S288C]. ACCESSION NP_010863 VERSION NP_010863.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178866.1 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07603. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..256 /product="H(+)-transporting V1 sector ATPase subunit D" /calculated_mol_wt="29063" Region 5..213 /region_name="V_ATPase_subD" /note="H(+)-transporting ATP synthase, vacuolar type, subunit D; TIGR00309" /db_xref="CDD:129409" CDS 1..256 /gene="VMA8" /locus_tag="YEL051W" /coded_by="NM_001178866.1:1..771" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016471 vacuolar proton-transporting V-type ATPase complex [PMID:10801866]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:29519938]" /experiment="EXISTENCE:mutant phenotype:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:10801866]" /note="Subunit D of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits" /db_xref="GeneID:856659" /db_xref="SGD:S000000777" ORIGIN 1 msgnreqvfp trmtlglmkt klkganqgys llkrksealt krfrditkri ddakqkmgrv 61 mqtaafslae vsyatgenig yqvqesvsta rfkvrarqen vsgvylsqfe syidpeindf 121 rltglgrggq qvqrakeiys ravetlvela slqtafiild evikvtnrrv naiehviipr 181 tentiayins eldeldreef yrlkkvqekk qnetakldae mklkrdraeq dasevaadee 241 pqgetlvadq eddvif // LOCUS NP_010864 393 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL2m RML2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010864 VERSION NP_010864.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178865.3 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07604. On Jul 30, 2012 this sequence version replaced NP_010864.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..393 /product="mitochondrial 54S ribosomal protein uL2m RML2" /calculated_mol_wt="43655" Region 93..388 /region_name="RplB" /note="Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]; COG0090" /db_xref="CDD:439860" CDS 1..393 /gene="RML2" /locus_tag="YEL050C" /gene_synonym="uL2m" /coded_by="NM_001178865.3:1..1182" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9445368]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9445368]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:9079633]" /note="Mitochondrial ribosomal protein of the large subunit (L2); has similarity to E. coli L2 ribosomal protein; mutant allele (fat21) causes inability to utilize oleate, and induce oleic acid oxidation; may interfere with activity of the Adr1p transcription factor" /db_xref="GeneID:856660" /db_xref="SGD:S000000776" ORIGIN 1 mlvlgslrsa lscsstasli skrnpcypyg ilcrtlsqsv klwqentskd dsslnitprl 61 lkiipndtdi vtlekqdeli krrrklskev tqmkrlkpvs pglrwyrspi ypylykgrpv 121 raltvvrkkh ggrnnsgkit vrhqggghrn rtrlidfnrw eggaqtvqri eydpgrsshi 181 allkhnttge lsyiiacdgl rpgdvvesfr rgipqtllne mggkvdpail svkttqrgnc 241 lpismipigt iihnvgitpv gpgkfcrsag tyarvlaklp ekkkaivrlq sgehryvsle 301 avatigvvsn idhqnrslgk agrsrwlgir ptvrgvamnk cdhphgggrg ksksnklsms 361 pwgqlakgyk trrgknqnrm kvkdrprgkd arl // LOCUS NP_010865 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010865 VERSION NP_010865.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178864.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07605. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..120 /product="seripauperin PAU2" /calculated_mol_wt="12688" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU2" /locus_tag="YEL049W" /coded_by="NM_001178864.1:1..363" /note="Member of the seripauperin multigene family; encoded mainly in subtelomeric region; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme" /db_xref="GeneID:856662" /db_xref="SGD:S000000775" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ysfqaahpte 61 typievaeav fnygdfttml tgiapdqvtr mitgvpwyss rlkpaissal skdgiytian // LOCUS NP_010866 152 aa linear PLN 30-JUN-2025 DEFINITION Tca17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010866 VERSION NP_010866.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178863.1 REFERENCE 1 (residues 1 to 152) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 152) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 152) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 152) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07606. Method: conceptual translation. FEATURES Location/Qualifiers source 1..152 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..152 /product="Tca17p" /calculated_mol_wt="17223" Region 10..143 /region_name="Sedlin_N" /note="Sedlin, N-terminal conserved region; cl21566" /db_xref="CDD:354875" CDS 1..152 /gene="TCA17" /locus_tag="YEL048C" /coded_by="NM_001178863.1:1..459" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:19220810]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:21453443]" /experiment="EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:19220810]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:21453443]" /note="Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; promotes association of TRAPPII-specific subunits with the TRAPP core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder" /db_xref="GeneID:856663" /db_xref="SGD:S000000774" ORIGIN 1 mslrpcfvsl idesdkpili yvpneaenem ndvlkynvls nisldyfesa lvewhsldsk 61 pllksifqle gvsvfamlik qtglkivigf eqkslsgadd efeainqife tvrkiyirvk 121 cnpllvsgde ksiikslerk fdelfistev el // LOCUS NP_010867 470 aa linear PLN 30-JUN-2025 DEFINITION fumarate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010867 VERSION NP_010867.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178862.3 REFERENCE 1 (residues 1 to 470) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 470) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 470) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 470) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07607. On Jul 30, 2012 this sequence version replaced NP_010867.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..470 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..470 /product="fumarate reductase" /EC_number="1.3.1.6" /calculated_mol_wt="50713" Region 5..463 /region_name="flavo_cyto_c" /note="flavocytochrome c; TIGR01813" /db_xref="CDD:273816" CDS 1..470 /gene="FRD1" /locus_tag="YEL047C" /coded_by="NM_001178862.3:1..1413" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9587404]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0016156 fumarate reductase (NADH) activity [PMID:8946166]" /experiment="EXISTENCE:genetic interaction:GO:0071454 cellular response to anoxia [PMID:9711846|PMID:17345583]" /note="Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication" /db_xref="GeneID:856664" /db_xref="SGD:S000000773" ORIGIN 1 mslspvvvig tglaglaaan elvnkynipv tilekassig gnsikassgi ngactetqrh 61 fhiedsprlf eddtiksakg kgvqelmakl andsplaiew lknefdlkld llaqlgghsv 121 arthrssgkl ppgfeivsal snnlkklaet kpelvkinld skvvdihekd gsisavvyed 181 kngekhmvsa ndvvfcsggf gfskemlkey apelvnlptt ngqqttgdgq rllqklgadl 241 idmdqiqvhp tgfidpndrs sswkflaaes lrglggilln pitgrrfvne lttrdvvtaa 301 iqkvcpqedn rallvmgekm ytdlknnldf ymfkklvqkl tlsqvvseyn lpitvaqlce 361 elqtyssftt kadplgrtvi lnefgsdvtp etvvfigevt pvvhftmgga rinvkaqvig 421 knderllkgl yaagevsggv hganrlggss llecvvfgrt aaesiandrk // LOCUS NP_010868 387 aa linear PLN 30-JUN-2025 DEFINITION threonine aldolase GLY1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010868 VERSION NP_010868.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178861.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07608. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..387 /product="threonine aldolase GLY1" /EC_number="4.1.2.48" /calculated_mol_wt="42684" Region 16..346 /region_name="TA_like" /note="Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; cd06502" /db_xref="CDD:99748" Site order(18,21..24,30,33..35,69,72..73,80,99..106,113..115, 212..213,219,234..235,238..239,249..250,320) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:99748" Site order(71..72,75,152,182,185,210,213) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99748" Site 213 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99748" CDS 1..387 /gene="GLY1" /locus_tag="YEL046C" /coded_by="NM_001178861.1:1..1164" /experiment="EXISTENCE:direct assay:GO:0004793 threonine aldolase activity [PMID:9163906]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12676688]" /experiment="EXISTENCE:direct assay:GO:0006545 glycine biosynthetic process [PMID:3086094]" /experiment="EXISTENCE:direct assay:GO:0006567 L-threonine catabolic process [PMID:3086094]" /experiment="EXISTENCE:direct assay:GO:0008732 L-allo-threonine aldolase activity [PMID:9151955]" /note="Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis" /db_xref="GeneID:856665" /db_xref="SGD:S000000772" ORIGIN 1 mtefelppky itaandlrsd tfttptaemm eaaleasigd avygedvdtv rleqtvarma 61 gkeaglfcvs gtlsnqiair thlmqppysi lcdyrahvyt heaaglails qamvvpvvps 121 ngdyltledi kshyvpddgd ihgaptrlis lentlhgivy pleelvrika wcmenglklh 181 cdgariwnaa aqsgvplkqy geifdsisic lsksmgapig svlvgnlkfv kkathfrkqq 241 gggirqsgmm armalvninn dwksqllysh slahelaeyc eakgiplesp adtnfvfinl 301 kaarmdpdvl vkkglkynvk lmggrvsfhy qvtrdtlekv klaiseafdy akehpfdcng 361 ptqiyrsest evdvdgnair eiktyky // LOCUS NP_010870 166 aa linear PLN 30-JUN-2025 DEFINITION Ies6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010870 VERSION NP_010870.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178859.1 REFERENCE 1 (residues 1 to 166) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 166) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 166) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 166) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07609. Method: conceptual translation. FEATURES Location/Qualifiers source 1..166 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..166 /product="Ies6p" /calculated_mol_wt="18402" Region 44..166 /region_name="YL1_C" /note="YL1 nuclear protein C-terminal domain; cl02154" /db_xref="CDD:470478" CDS 1..166 /gene="IES6" /locus_tag="YEL044W" /coded_by="NM_001178859.1:1..501" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Component of the INO80 chromatin remodeling complex; critical for INO80 function; involved in regulation of chromosome segregation and maintenance of normal centromeric chromatin structure; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes" /db_xref="GeneID:856667" /db_xref="SGD:S000000770" ORIGIN 1 msgsrgnssn ssvsnnsnnn nnndggderl lflrsvgern eigfpsrfks ahykkptrrh 61 ksarqlisde nkrinalltk ankaaessta arrlvpkaty fsveappsir pakkycdvtg 121 lkgfyksptn niryhnaeiy qlivkpmapg vdqeylklrg anfvlk // LOCUS NP_010871 956 aa linear PLN 30-JUN-2025 DEFINITION Gta1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010871 VERSION NP_010871.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178858.3 REFERENCE 1 (residues 1 to 956) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 956) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 956) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 956) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 956) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 956) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 956) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 956) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 956) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07610. On Jul 30, 2012 this sequence version replaced NP_010871.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..956 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..956 /product="Gta1p" /calculated_mol_wt="106002" Region 39..124 /region_name="FN3" /note="Fibronectin type 3 domain; smart00060" /db_xref="CDD:214495" Region <205..>480 /region_name="Mplasa_alph_rch" /note="helix-rich Mycoplasma protein; TIGR04523" /db_xref="CDD:275316" CDS 1..956 /gene="GTA1" /locus_tag="YEL043W" /coded_by="NM_001178858.3:1..2871" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; proposed role in Golgi vesicle trafficking based on phenotypic profile, presence of a coiled-coil domain often associated with vesicle tethering proteins, and interaction profile process enrichment; may interact with ribosomes, based on co-purification studies; localizes to the ER and cell periphery in HTP studies; contains fibronectin type III domain fold" /db_xref="GeneID:856668" /db_xref="SGD:S000000769" ORIGIN 1 mpvsvittvl aclwlsyrly kfltipvssi vstlkiktpp atkvsidkia tdsvtihwen 61 epvkaedngs adrnfishyl lylnntqlai fpnnpnslyt ccsitgleae tqyqldfiti 121 nnkgfinklp siycmtkare anealktrkw rrntitssta mqprnsksep aplpshyssv 181 slstfssnit nsatsnngsn lpaytslttl kdldsfsidd lkkilicaqe dlhdvlsqqt 241 sllqdfqesk leleleldnl kthwsheidl rkslksniks lensklltdl kieklnkkid 301 kskekiskmr ndmqkwsqed tellskdtik ekyfkllnes nasvaninke ieslqneisk 361 meesnkrlna skkslitsiv vnanvendkp iasgelsavl kklndftlek ngflsnagee 421 flsklnadss likmikqels idqeleanwk lqrsnllkki salenqfnem slnnrnlktk 481 lmvqpyknng dslaatnsnn saeknrssgs iqlplsnnms rtgsidlisn nnksinnsna 541 dsapplrlhn pvsyspsnep iqpsssllsq ltqdtdnrsm lsnhissnne nkqqpssysh 601 alpttatana tatatatngh srsnlwttaq faqpshqqvs teldqafeyd nanhlisglq 661 nmiydetdyp dnisnyskgf ttdeldnywt kqqpqvrstn eslfsttgtp mssykanpvi 721 spyssshlrq tsnatntnpm hpqsllaatl ndpslqsfvr sgsfysapqp anslqnning 781 netenispri ssdfnllvpn lsprlsndvp ivpgnnttlt pshsniltmn hqptadnitr 841 rsfhassppf nsiwnsntnq lsppleeqyh ldvpvgpkvp akepspkpsh krnqsnssis 901 sawskfkhks asspanadtd iqdsstpsts psgrrmskll sksgmnnlfn phshds // LOCUS NP_010872 518 aa linear PLN 30-JUN-2025 DEFINITION guanosine diphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010872 VERSION NP_010872.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178857.1 REFERENCE 1 (residues 1 to 518) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 518) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 518) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 518) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07611. Method: conceptual translation. FEATURES Location/Qualifiers source 1..518 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..518 /product="guanosine diphosphatase" /EC_number="3.6.1.42" /calculated_mol_wt="56691" Region 93..506 /region_name="ASKHA_NBD_GDA1" /note="nucleotide-binding domain (NBD) of yeast guanosine-diphosphatase (GDA1) and similar proteins; cd24040" /db_xref="CDD:466890" CDS 1..518 /gene="GDA1" /locus_tag="YEL042W" /coded_by="NM_001178857.1:1..1557" /experiment="EXISTENCE:direct assay:GO:0004382 GDP phosphatase activity [PMID:7506254]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:9614179]" /experiment="EXISTENCE:direct assay:GO:0045134 UDP phosphatase activity [PMID:11425802]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:8391537]" /note="Guanosine diphosphatase located in the Golgi; involved in the transport of GDP-mannose into the Golgi lumen, converting GDP to GMP after mannose is transferred to substrates; null mutants are defective in sporulation and pre-meiotic S phase entry; orthologous to human ENTPD6, a meiosis-associated non-obstructive azoospermia (NOA) related gene identified in GWAS studies" /db_xref="GeneID:856669" /db_xref="SGD:S000000768" ORIGIN 1 mapifrnyrf aigafaviml illiktssig ppsiartvtp nasipktped isilpvndep 61 gylqdskteq nypeladavk sqtsqtcsee hkyvimidag stgsrvhiyk fdvctspptl 121 ldekfdmlep glssfdtdsv gaansldpll kvamnyvpik arsctpvavk ataglrllgd 181 aksskilsav rdhlekdypf pvvegdgvsi mggdeegvfa wittnyllgn igangpklpt 241 aavfdlgggs tqivfeptfp inekmvdgeh kfdlkfgden ytlyqfshlg yglkegrnkv 301 nsvlvenalk dgkilkgdnt kthqlsspcl ppkvnatnek vtlesketyt idfigpdeps 361 gaqcrfltde ilnkdaqcqs ppcsfngvhq pslvrtfkes ndiyifsyfy drtrplgmpl 421 sftlnelndl arivckgeet wnsvfsgiag sldelesdsh fcldlsfqvs llhtgydipl 481 qrelrtgkki ankeigwclg aslpllkadn wkckiqsa // LOCUS NP_010873 495 aa linear PLN 30-JUN-2025 DEFINITION NADH/NAD(+) kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010873 VERSION NP_010873.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178856.1 REFERENCE 1 (residues 1 to 495) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 495) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 495) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 495) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07612. Method: conceptual translation. FEATURES Location/Qualifiers source 1..495 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..495 /product="NADH/NAD(+) kinase" /EC_number="2.7.1.86" /calculated_mol_wt="55743" Region <107..428 /region_name="DAGK_cat" /note="Diacylglycerol kinase catalytic domain; cl01255" /db_xref="CDD:445337" CDS 1..495 /gene="YEF1" /locus_tag="YEL041W" /coded_by="NM_001178856.1:1..1488" /experiment="EXISTENCE:direct assay:GO:0003951 NAD+ kinase activity [PMID:15978040]" /experiment="EXISTENCE:direct assay:GO:0006741 NADP+ biosynthetic process [PMID:15978040]" /experiment="EXISTENCE:direct assay:GO:0042736 NADH kinase activity [PMID:15978040]" /note="ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication" /db_xref="GeneID:856670" /db_xref="SGD:S000000767" ORIGIN 1 mktdrllina spetctkgda emdtmdtidr mtsvkvlaeg kvlsnfeepg lmrcgyhdak 61 nwvrrlsset ivgedtsnly pfyvdtaydv rrlrkdlina kvdlqvenli iicnindist 121 vflmrevvew ilrnfhsitv yvqdifkkst qfavgdlckd sncsknrvky wskefvkkhd 181 sffdlmitlg gdgtvlfass iftkdvppiv pfalgslgfl tnfefqnfke tlkhiltdev 241 rinlrmrlqc klyrrnkpei daatgrkicy idfisehhvl nevtidrgpa pclsllelyg 301 ndslmtkvqg dglivatptg stayslsagg slispsvnai avtpicphtl sfrpiilpds 361 melkvrvdmn srgtswvnfd gkdrvelkqg dyvvitaspy svptiessas effesisknl 421 nwndreeqkp fahilspknq ekyrldsskn gndtisnple sscissdaqd eerksvtete 481 teivvertrq ahfai // LOCUS NP_010874 467 aa linear PLN 30-JUN-2025 DEFINITION chitin transglycosylase UTR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010874 VERSION NP_010874.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178855.3 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07613. On Jul 30, 2012 this sequence version replaced NP_010874.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..467 /product="chitin transglycosylase UTR2" /calculated_mol_wt="49775" Region 25..71 /region_name="ChtBD1_GH16" /note="Hevein or Type 1 chitin binding domain subfamily that co-occurs with family 16 glycosyl hydrolases; cd06923" /db_xref="CDD:211314" Site order(41,43..45,47,51) /site_type="other" /note="carbohydrate binding site [chemical binding]" /db_xref="CDD:211314" Region 91..302 /region_name="GH16_fungal_CRH1_transglycosylase" /note="glycosylphosphatidylinositol-glucanosyltransferase; cd02183" /db_xref="CDD:185692" Site order(126,154,156,158,166,168,170,180,182,195,255,257) /site_type="active" /db_xref="CDD:185692" Site order(166,168,170) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:185692" CDS 1..467 /gene="UTR2" /locus_tag="YEL040W" /gene_synonym="CRH2" /coded_by="NM_001178855.3:1..1404" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:12045225]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953|PMID:15781460]" /experiment="EXISTENCE:direct assay:GO:0016757 glycosyltransferase activity [PMID:23919454]" /experiment="EXISTENCE:genetic interaction:GO:0006030 chitin metabolic process [PMID:18694928]" /experiment="EXISTENCE:genetic interaction:GO:0016757 glycosyltransferase activity [PMID:18694928]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:18694928]" /experiment="EXISTENCE:mutant phenotype:GO:0006030 chitin metabolic process [PMID:18694928]" /experiment="EXISTENCE:mutant phenotype:GO:0016757 glycosyltransferase activity [PMID:18694928]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:18694928]" /note="Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck" /db_xref="GeneID:856671" /db_xref="SGD:S000000766" ORIGIN 1 maivnswlic lvsifsfvvr veaatfcnat qacpedkpcc sqygecgtgq yclnncdvry 61 sfshdscmpv pickssstkf kdyssklgna ntflgnvsea dwlytgdvld yddeeslila 121 mpknsggtvl sstravwygk vsariktshl agvvtgfily sgagdeldye fvgadletaq 181 tnfywesvln ytnsanistt dtfenyhtye ldwhedyvtw sidgvvgrtl yknetynatt 241 qkyqypqtps kvdisiwpgg nstnapgtia wsggeinwda sdisnpgyyy aivnevnitc 301 ydppsdtkkn gtsayvytss seflakdiai tddevmmdsd egsgldphkg attsstqkss 361 sstatssskt ssdhssstkk ssktsstass ssssssssss ssstatkngd kvvssvsssv 421 tsqtqttssv sgsassstss msgnnaganv aanwrltvlc vilgyvl // LOCUS NP_010875 113 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c isoform 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010875 VERSION NP_010875.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178854.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07614. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..113 /product="cytochrome c isoform 2" /calculated_mol_wt="12401" Region 11..108 /region_name="Cyc7" /note="Cytochrome c2 [Energy production and conversion]; COG3474" /db_xref="CDD:442697" CDS 1..113 /gene="CYC7" /locus_tag="YEL039C" /coded_by="NM_001178854.1:1..342" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:8636074]" /experiment="EXISTENCE:direct assay:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:7814361]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:7814361]" /experiment="EXISTENCE:direct assay:GO:0009055 electron transfer activity [PMID:7814361]" /note="Cytochrome c isoform 2, expressed under hypoxic conditions; also known as iso-2-cytochrome c; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; protein abundance increases in response to DNA replication stress; CYC7 has a paralog, CYC1, that arose from the whole genome duplication" /db_xref="GeneID:856672" /db_xref="SGD:S000000765" ORIGIN 1 makestgfkp gsakkgatlf ktrcqqchti eeggpnkvgp nlhgifgrhs gqvkgysytd 61 aninknvkwd edsmseyltn pkkyipgtkm afaglkkekd rndlitymtk aak // LOCUS NP_010876 227 aa linear PLN 30-JUN-2025 DEFINITION putative acireductone synthase UTR4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010876 VERSION NP_010876.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178853.1 REFERENCE 1 (residues 1 to 227) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 227) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 227) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 227) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07615. On May 22, 2006 this sequence version replaced NP_010876.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..227 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..227 /product="putative acireductone synthase UTR4" /EC_number="3.1.3.77" /calculated_mol_wt="25056" Region 7..208 /region_name="HAD_EP" /note="Enolase-phosphatase similar to human enolase-phosphatase E1 and and Xanthomonas oryzae pv. Oryzae enolase-phosphatase Xep; cd01629" /db_xref="CDD:319768" Site order(11..15,22,26..27,87,118..120,124,161,185..186, 190..191) /site_type="active" /db_xref="CDD:319768" CDS 1..227 /gene="UTR4" /locus_tag="YEL038W" /coded_by="NM_001178853.1:1..684" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:18625006]" /note="Protein with sequence similarity to acireductone synthases; involved in methionine salvage; found in both the cytoplasm and nucleus" /db_xref="GeneID:856673" /db_xref="SGD:S000000764" ORIGIN 1 mgdnystyll diegtvcpis fvketlfpyf tnkvpqlvqq dtrdspvsni lsqfhidnke 61 qlqahilelv akdvkdpilk qlqgyvwahg yesgqikapv yadaidfikr kkrvfiyssg 121 svkaqkllfg yvqdpnapah dsldlnsyid gyfdintsgk ktetqsyani lrdigakase 181 vlflsdnple ldaaagvgia tglasrpgna pvpdgqkyqv yknfetl // LOCUS NP_010877 398 aa linear PLN 30-JUN-2025 DEFINITION Rad23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010877 VERSION NP_010877.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178852.3 REFERENCE 1 (residues 1 to 398) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 398) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 398) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 398) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07616. On Jul 30, 2012 this sequence version replaced NP_010877.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..398 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..398 /product="Rad23p" /calculated_mol_wt="42236" Region 2..398 /region_name="rad23" /note="UV excision repair protein Rad23; TIGR00601" /db_xref="CDD:273167" CDS 1..398 /gene="RAD23" /locus_tag="YEL037C" /coded_by="NM_001178852.3:1..1197" /experiment="EXISTENCE:direct assay:GO:0000111 nucleotide-excision repair factor 2 complex [PMID:7768886]" /experiment="EXISTENCE:direct assay:GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [PMID:20016784]" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:9813069|PMID:9837874]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006517 protein deglycosylation [PMID:20016784]" /experiment="EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:11323716]" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:15242647|PMID:15117949|PMID:25311859]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:26150418]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:15167887]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:19889839]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:15121879]" /note="Proteasome-associated ubiquitin receptor; K48-specific Ub chain binding protein that recruits substrates to the proteasome; subunit of nuclear excision repair factor 2 (NER2) with Rad4p that binds damaged DNA during NER, linking repair to proteolysis; NER2 binds DDR gene promoters to repress transcription in the absence of damage; stimulates Png1p-induced protein deglycosylation; contains a Ub-like (UBL) and two Ub-associated (UBA) domains; UBA2 protects Rad23p from proteasomal degradation" /db_xref="GeneID:856674" /db_xref="SGD:S000000763" ORIGIN 1 mvsltfknfk kekvpldlep sntiletktk laqsiscees qikliysgkv lqdsktvsec 61 glkdgdqvvf mvsqkkstkt kvteppiape sattpgrens teaspstdas aapaatapeg 121 sqpqeeqtat tertesastp gfvvgterne tierimemgy qreeveralr aafnnpdrav 181 eyllmgipen lrqpepqqqt aaaaeqpsta attaeqpaed dlfaqaaqgg nassgalgtt 241 ggatdaaqgg ppgsigltve dllslrqvvs gnpealapll enisarypql rehimanpev 301 fvsmlleavg dnmqdvmega ddmvegedie vtgeaaaagl gqgegegsfq vdytpeddqa 361 isrlcelgfe rdlviqvyfa cdkneeaaan ilfsdhad // LOCUS NP_010878 500 aa linear PLN 30-JUN-2025 DEFINITION Anp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010878 VERSION NP_010878.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178851.1 REFERENCE 1 (residues 1 to 500) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 500) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 500) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 500) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07617. Method: conceptual translation. FEATURES Location/Qualifiers source 1..500 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..500 /product="Anp1p" /calculated_mol_wt="58051" Region 61..323 /region_name="Anp1" /note="pfam03452" /db_xref="CDD:427303" CDS 1..500 /gene="ANP1" /locus_tag="YEL036C" /gene_synonym="GEM3; MNN8" /coded_by="NM_001178851.1:1..1503" /experiment="EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:10037752]" /experiment="EXISTENCE:direct assay:GO:0000136 mannan polymerase complex [PMID:9430634]" /experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:9430634]" /experiment="EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:9430634]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9430634]" /note="Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol" /db_xref="GeneID:856675" /db_xref="SGD:S000000762" ORIGIN 1 mkynnrklsf npttvsiagt lltvffltrl vlsffsislf qlvtfqgifk pyvpdfkntp 61 svefydlrny qgnkdgwqqg drilfcvplr dasehlpmff nhlntmtyph nlidlsflvs 121 dssdntmgvl lsnlqmaqsq qdkskrfgni eiyekdfgqi igqsfsdrhg fgaqgprrkl 181 mararnwlgs valkpyhswv ywrdvdveti pttimedlmh hdkdvivpnv wrplpdwlgn 241 iqpydlnswk esegglqlad sldedavive gypeyatwrp hlaymrdpng npedemeldg 301 iggvsilaka kvfrtgshfp afsfekhaet eafgrlsrrm nynviglphy viwhiyepss 361 ddlkhmawma eeekrkleee rirefynkiw eigfedvrdq wneerdsilk nidstlnnkv 421 tvdwseegdg selvdskgdf vspnnqqqqq qqqqqqqqqq qqqqqqqldg npqgkplddn 481 dknkkkhpke vpldfdpdrn // LOCUS NP_010879 166 aa linear PLN 30-JUN-2025 DEFINITION Utr5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010879 VERSION NP_010879.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178850.1 REFERENCE 1 (residues 1 to 166) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 166) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 166) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 166) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07618. Method: conceptual translation. FEATURES Location/Qualifiers source 1..166 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..166 /product="Utr5p" /calculated_mol_wt="19204" CDS 1..166 /gene="UTR5" /locus_tag="YEL035C" /coded_by="NM_001178850.1:1..501" /note="hypothetical protein; originally considered essential but deletion overlapped the TATA box of neighboring essential gene HYP2, while deletion that avoids the HYP2 TATA box is viable; transcription may be regulated by Gcr1p" /db_xref="GeneID:856676" /db_xref="SGD:S000000761" ORIGIN 1 msrygknlvh yiivehddqr gqkpidddde knfyyhcsft fetffrataf llapavcavr 61 evpcrltrtr ynateyiegy gwmislqqgl gvaefyrpwp lsvqlqrytt psrrsrfavl 121 tpqrkchqne angqdlslli llsriyplcs ntsqtrrvaa rkgkls // LOCUS NP_010880 157 aa linear PLN 30-JUN-2025 DEFINITION translation elongation factor eIF-5A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010880 VERSION NP_010880.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178849.3 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07619. On Jul 30, 2012 this sequence version replaced NP_010880.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..157 /product="translation elongation factor eIF-5A" /calculated_mol_wt="16983" Region 1..153 /region_name="PLN03107" /note="eukaryotic translation initiation factor 5A; Provisional" /db_xref="CDD:215580" CDS 1..157 /gene="HYP2" /locus_tag="YEL034W" /gene_synonym="TIF51A" /coded_by="NM_001178849.3:1..474" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:19120453]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:21451136]" /experiment="EXISTENCE:direct assay:GO:0003746 translation elongation factor activity [PMID:19424157]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:16215987]" /experiment="EXISTENCE:direct assay:GO:0045901 positive regulation of translational elongation [PMID:19424157]" /experiment="EXISTENCE:direct assay:GO:0045905 positive regulation of translational termination [PMID:19424157]" /experiment="EXISTENCE:direct assay:GO:0045948 positive regulation of translational initiation [PMID:21451136]" /experiment="EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:11861547]" /experiment="EXISTENCE:genetic interaction:GO:0006452 translational frameshifting [PMID:19424157]" /experiment="EXISTENCE:genetic interaction:GO:0045901 positive regulation of translational elongation [PMID:19338753|PMID:19424157]" /experiment="EXISTENCE:mutant phenotype:GO:0003746 translation elongation factor activity [PMID:19424157]" /experiment="EXISTENCE:mutant phenotype:GO:0045901 positive regulation of translational elongation [PMID:19338753|PMID:19424157]" /experiment="EXISTENCE:mutant phenotype:GO:1903272 positive regulation of cytoplasmic translational elongation through polyproline stretches [PMID:24923804]" /note="Translation elongation factor eIF-5A; required for translation of proteins containing polyproline stretches; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has paralog ANB1 that arose from whole genome duplication; in humans EIF5A variants cause a disorder characterized by variable combinations of developmental delay, microcephaly, micrognathia and dysmorphism; human EIF5A complements inviability of yeast hyp2 anb1 double null mutant" /db_xref="GeneID:856677" /db_xref="SGD:S000000760" ORIGIN 1 msdeehtfet adagssatyp mqcsalrkng fvviksrpck ivdmstsktg khghakvhlv 61 aidiftgkkl edlspsthnm evpvvkrney qlldiddgfl slmnmdgdtk ddvkapegel 121 gdslqtafde gkdlmvtiis amgeeaaisf keaartd // LOCUS NP_010881 139 aa linear PLN 30-JUN-2025 DEFINITION Mtc7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010881 VERSION NP_010881.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178848.1 REFERENCE 1 (residues 1 to 139) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 139) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 139) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 139) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07620. Method: conceptual translation. FEATURES Location/Qualifiers source 1..139 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..139 /product="Mtc7p" /calculated_mol_wt="15963" CDS 1..139 /gene="MTC7" /locus_tag="YEL033W" /coded_by="NM_001178848.1:1..420" /note="hypothetical protein; predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant" /db_xref="GeneID:856678" /db_xref="SGD:S000000759" ORIGIN 1 mkkekktptp lpshhvlfae pgfflcnfff vllkhtqinp ffyflfillf iiyiaiiyfv 61 firishfsfs lcrqcnslgr mifmcaylpa assrsvanpa lppqkkkkkk kkgtlrtgev 121 eeqakgnisf dlcgkqnfq // LOCUS NP_010882 971 aa linear PLN 30-JUN-2025 DEFINITION MCM DNA helicase complex subunit MCM3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010882 VERSION NP_010882.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178847.1 REFERENCE 1 (residues 1 to 971) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 971) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 971) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 971) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07621. Method: conceptual translation. FEATURES Location/Qualifiers source 1..971 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..971 /product="MCM DNA helicase complex subunit MCM3" /EC_number="3.6.4.12" /calculated_mol_wt="107387" Region 25..143 /region_name="MCM_N" /note="MCM N-terminal domain; pfam14551" /db_xref="CDD:464206" Region 166..738 /region_name="MCM" /note="MCM helicase family; cl28901" /db_xref="CDD:475121" Site order(367,369..371,391,395..399,411,416..417,420..421,424, 430..433,435,437,450..451,457,459,464,466..467,474,484, 487..488,492,496,498..499,503..505,507,520,537,541, 558..559,561..562,565..566,568..570,653,671,676,679..680, 684,687..688,698,700,702,706) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:350660" Site order(370..372,411..417,491,542,699..700,703) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350660" Site order(438,444..445,447..448,499) /site_type="other" /note="nucleic acid binding site [nucleotide binding]" /db_xref="CDD:350660" CDS 1..971 /gene="MCM3" /locus_tag="YEL032W" /coded_by="NM_001178847.1:1..2916" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:11756674|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8224843|PMID:10704410]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:8224843|PMID:10704410]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12480933]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:18657510]" /experiment="EXISTENCE:direct assay:GO:0042555 MCM complex [PMID:12480933]" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:direct assay:GO:1904931 MCM complex binding [PMID:26912723]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:12060653]" /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:10834843]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:12480933]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:19064704]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:19064704]" /experiment="EXISTENCE:mutant phenotype:GO:1902975 mitotic DNA replication initiation [PMID:8224843]" /experiment="EXISTENCE:physical interaction:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /note="Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex" /db_xref="GeneID:856680" /db_xref="SGD:S000000758" ORIGIN 1 megstgfdgd attffapdav fgdrvrrfqe fldtftsyrd svrsiqvyns nnaanynddq 61 ddaderdllg dddgddleke kkaasstsln ilphriiisl ddlrefdrsf wsgilvepay 121 fippaekalt dladsmddvp hpnasavssr hpwklsfkgs fgahalsprt ltaqhlnklv 181 svegivtkts lvrpklirsv hyaaktgrfh yrdytdattt lttriptpai yptedtegnk 241 ltteygystf idhqritvqe mpemapagql prsidvildd dlvdktkpgd rvnvvgvfks 301 lgaggmnqsn sntligfktl ilgntvyplh arstgvaarq mltdfdirni nklskkkdif 361 dilsqslaps iyghdhikka illmlmggve knlengshlr gdinilmvgd pstaksqllr 421 fvlntaslai attgrgssgv gltaavttdr etgerrleag amvladrgvv cidefdkmtd 481 vdrvaihevm eqqtvtiaka gihttlnarc sviaaanpvf gqydvnrdph qnialpdsll 541 srfdllfvvt ddineirdrs isehvlrthr ylppgylege pvrerlnlsl avgedadinp 601 eehsnsgagv enegeddedh vfekfnpllq agaklaknkg nyngteipkl vtipflrkyv 661 qyakervipq ltqeainviv knytdlrndd ntkkspitar tletlirlat ahakvrlskt 721 vnkvdakvaa nllrfallge digndideee seyeealskr spqkspkkrq rvrqpasnsg 781 spikstprrs tassvnatps sarrilrfqd deqnageddn dimsplpade eaelqrrlql 841 glrvsprrre hlhapeegss gpltevgtpr lpnvssagqd deqqqsvisf dnvepgtist 901 grlslisgii arlmqteife eesypvaslf erineelpee ekfsaqeyla glkimsdrnn 961 lmvaddkvwr v // LOCUS NP_010883 1215 aa linear PLN 30-JUN-2025 DEFINITION ion-transporting P-type ATPase SPF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010883 VERSION NP_010883.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178846.3 REFERENCE 1 (residues 1 to 1215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1215) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07622. On Jul 30, 2012 this sequence version replaced NP_010883.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1215 /product="ion-transporting P-type ATPase SPF1" /calculated_mol_wt="135138" Region 169..1136 /region_name="P-type_ATPase_cation" /note="P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; cd07543" /db_xref="CDD:319843" Site order(487..489,582,604..606,636,697..699,791,794,797,816, 819) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:319843" Site order(993,997..998,1000..1001,1028,1031..1032) /site_type="other" /note="putative cation binding site [ion binding]" /db_xref="CDD:319843" CDS 1..1215 /gene="SPF1" /locus_tag="YEL031W" /gene_synonym="COD1; PER9; PIO1" /coded_by="NM_001178846.3:1..3648" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:22745129|PMID:12058017|PMID:30785834]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:11791712]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:30785834]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:12058017]" /experiment="EXISTENCE:mutant phenotype:GO:0030026 intracellular manganese ion homeostasis [PMID:24392018]" /experiment="EXISTENCE:mutant phenotype:GO:0055092 sterol homeostasis [PMID:22918956|PMID:30785834]" /note="P-type ATPase, ion transporter of the ER membrane; required to maintain normal lipid and sterol composition of intracellular compartments and proper targeting of mitochondrial outer membrane tail-anchored proteins; involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1; null mutation is complemented by human Parkinson disease-related ATP13A1" /db_xref="GeneID:856681" /db_xref="SGD:S000000757" ORIGIN 1 mtkksfvssp ivrdstllvp ksliakpyvl pffplyatfa qlyfqqydry ikgpewtfvy 61 lgtlvslnil vmlmpawnvk ikakfnystt knvneathil iyttpnngsd giveiqrvte 121 agslqtffqf qkkrflwhen eqvfsspkfl vdespkigdf qkckghsgdl thlkrlygen 181 sfdipiptfm elfkehavap lfvfqvfcva lwlldefwyy slfnlfmiis meaaavfqrl 241 talkefrtmg ikpytinvfr nkkwvalqtn ellpmdlvsi trtaeesaip cdlilldgsa 301 ivneamlsge stpllkesik lrpsednlql dgvdkiavlh ggtkalqvtp pehksdippp 361 pdggalaivt ktgfetsqgs lvrvmiysae rvsvdnkeal mfilfllifa viaswyvwve 421 gtkmgriqsk lildciliit svvppelpme ltmavnssla alakfyvyct epfripfagr 481 idvccfdktg tltgedlvfe glagisadse nirhlysaae apestilvig aahalvkled 541 gdivgdpmek atlkavgwav erknsnyreg tgkldiirrf qfssalkrsa siashndalf 601 aavkgapeti rerlsdipkn ydeiyksftr sgsrvlalas kslpkmsqsk iddlnrddve 661 seltfngfli fhcplkddai etikmlness hrsimitgdn pltavhvake vgivfgetli 721 ldragksddn qllfrdveet vsipfdpskd tfdhsklfdr ydiavtgyal naleghsqlr 781 dllrhtwvya rvspsqkefl lntlkdmgyq tlmcgdgtnd vgalkqahvg iallngteeg 841 lkklgeqrrl egmkmmyikq tefmarwnqp qppvpepiah lfppgpknph ylkaleskgt 901 vitpeirkav eeanskpvev ikpnglsekk padlasllln sagdaqgdea palklgdasc 961 aapftsklan vsavtniirq grcalvntiq mykilalncl isayslsiiy magvkfgdgq 1021 atvsglllsv cflsisrgkp leklskqrpq sgifnvyimg silsqfavhi atlvyittei 1081 ykleprepqv dlekefapsl lntgifiiql vqqvstfavn yqgepfreni rsnkgmyygl 1141 lgvtglalas ateflpelne amkfvpmtdd fkikltltll ldffgswgve hffkfffmdd 1201 kpsdisvqqv kiask // LOCUS NP_010884 644 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family ATPase ECM10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010884 VERSION NP_010884.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178845.1 REFERENCE 1 (residues 1 to 644) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 644) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 644) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 644) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07623. Method: conceptual translation. FEATURES Location/Qualifiers source 1..644 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..644 /product="Hsp70 family ATPase ECM10" /calculated_mol_wt="69954" Region 29..644 /region_name="dnaK" /note="molecular chaperone DnaK; Provisional; PRK00290" /db_xref="CDD:234715" CDS 1..644 /gene="ECM10" /locus_tag="YEL030W" /gene_synonym="SSC3" /coded_by="NM_001178845.1:1..1935" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:11150530|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006626 protein targeting to mitochondrion [PMID:11150530]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:12943685]" /note="Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication" /db_xref="GeneID:856682" /db_xref="SGD:S000000756" ORIGIN 1 mlpswkafka hnilriltrf qstkipdavi gidlgttnsa vaimegkvpr iienaegsrt 61 tpsvvaftkd gerlvgepak rqsvinsent lfatkrligr rfedaevqrd inqvpfkivk 121 hsngdawvea rnrtyspaqi ggfilnkmke taeaylaksv knavvtvpay fndaqrqatk 181 dagqiiglnv lrvvneptaa alaygldkse pkviavfdlg ggtfdisild idngifevks 241 tngdthlgge dfdiyllqei ishfkketgi dlsndrmavq rireaaekak ielsstlste 301 inlpfitada agpkhirmpf srvqlenita plidrtvdpv kkalkdarit asdisdvllv 361 ggmsrmpkva dtvkklfgkd askavnpdea valgaaiqaa vlsgevtdvl lldvtplslg 421 ietlggvftk liprnstipn kksqifstaa sgqtsvevkv fqgerelvkd nklignftla 481 gippapkgtp qievtfdida ngiinvsakd lashkdssit vagasglsdt eidrmvneae 541 ryknqdrarr naietankad qlandtensi kefegkldkt dsqrlkdqis slrelvsrsq 601 agdevndddv gtkidnlrts smklfeqlyk nsdnpetkng renk // LOCUS NP_010885 312 aa linear PLN 30-JUN-2025 DEFINITION putative pyridoxal kinase BUD16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010885 VERSION NP_010885.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178844.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07624. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..312 /product="putative pyridoxal kinase BUD16" /EC_number="2.7.1.35" /calculated_mol_wt="35428" Region 3..266 /region_name="pyridoxal_pyridoxamine_kinase" /note="Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; cd01173" /db_xref="CDD:238578" Site order(3,10,12..13,15,19,23,26,31..36,39,42,53..54,56, 63..64,71) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238578" Site order(9,16..17,40,43..44,51,83,85,220..221,224) /site_type="other" /note="pyridoxal binding site [chemical binding]" /db_xref="CDD:238578" Site order(112,117,146,148,151,183..184,196,212,214..215,219, 222..224,226,258,262) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238578" CDS 1..312 /gene="BUD16" /locus_tag="YEL029C" /coded_by="NM_001178844.1:1..939" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:genetic interaction:GO:0042823 pyridoxal phosphate biosynthetic process [PMID:17696614]" /experiment="EXISTENCE:mutant phenotype:GO:0042823 pyridoxal phosphate biosynthetic process [PMID:17696614]" /note="Putative pyridoxal kinase; a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; localizes to cytosol and peroxisomes; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)" /db_xref="GeneID:856683" /db_xref="SGD:S000000755" ORIGIN 1 mprllatqsh vvhgyvgnka atfplqclgw dvdccnsvqf snhtgygldk vfgtitretd 61 lkellsglfd nfsqdyqall sgylpnknsv rcmgtyyakf keanpemiwl mdpvmgdegq 121 lyvsedvipe yrklalspkq lvdiitpnqf eleilyggei ktkehlkkal kklhqtipvi 181 ivtscdckmf ddkdfiycva smegktpivy rvpfidsyft gvgdlfsall ldrvykilsn 241 ptttlkfedq vnnvlnviqk vlkitrsyas gkmkakmgsa lemkemelrl iesrdiyeti 301 nihqtdyiya rl // LOCUS NP_001335764 153 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL028W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335764 VERSION NP_001335764.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348820.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80284. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..153 /product="uncharacterized protein" /calculated_mol_wt="17229" CDS 1..153 /locus_tag="YEL028W" /coded_by="NM_001348820.1:1..462" /note="hypothetical protein; conserved among S. cerevisiae strains; YEL028W is not an essential gene" /db_xref="GeneID:856684" /db_xref="SGD:S000000754" ORIGIN 1 mkititsllf flvmivelas agtllhngan lpslrdnttl tdarnvlkyl qvlgfpsnki 61 aatdtvgtfi ifsnrteant tamtktvsyc yrnyghsfyf thykydyfps gisymaklgd 121 atvnhtdlph frnnkrlttq elnafqhpiv efq // LOCUS NP_010887 160 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V0 sector ATPase subunit c [Saccharomyces cerevisiae S288C]. ACCESSION NP_010887 VERSION NP_010887.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178842.3 REFERENCE 1 (residues 1 to 160) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 160) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 160) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07625. On Jul 30, 2012 this sequence version replaced NP_010887.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..160 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..160 /product="H(+)-transporting V0 sector ATPase subunit c" /calculated_mol_wt="16220" Region 11..116 /region_name="V_ATP_synt_C" /note="vacuolar ATP synthase 16 kDa proteolipid subunit; TIGR01100" /db_xref="CDD:130170" Region 84..151 /region_name="ATP-synt_Vo_c_ATP6C_rpt2" /note="V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins; cd18176" /db_xref="CDD:349416" CDS 1..160 /gene="VMA3" /locus_tag="YEL027W" /gene_synonym="CLS7; CUP5; GEF2" /coded_by="NM_001178842.3:1..483" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15252052]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:2145283]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:9434348]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9434348]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:2145283]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:2145283]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:2145283]" /note="Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase; dicyclohexylcarbodiimide binding subunit; required for vacuolar acidification and important for copper and iron metal ion homeostasis" /db_xref="GeneID:856686" /db_xref="SGD:S000000753" ORIGIN 1 mtelcpvyap ffgaigcasa iiftslgaay gtaksgvgic atcvlrpdll fknivpvima 61 giiaiyglvv svlvcyslgq kqalytgfiq lgaglsvgls glaagfaigi vgdagvrgss 121 qqprlfvgmi lilifaevlg lyglivalll nsratqdvvc // LOCUS NP_010888 126 aa linear PLN 30-JUN-2025 DEFINITION RNA binding protein SNU13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010888 VERSION NP_010888.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178841.1 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07626. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..126 /product="RNA binding protein SNU13" /calculated_mol_wt="13438" Region 5..126 /region_name="SNU13" /note="U4/U6.U5 small nuclear ribonucleoprotein SNU13; cd21104" /db_xref="CDD:411046" Site order(34..39,42,46,58..59,63,84,93..98) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:411046" Site order(38,41..42,45,60,62..63,65..66,69) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:411046" CDS 1..126 /gene="SNU13" /locus_tag="YEL026W" /coded_by="NM_001178841.1:1..381" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0030621 U4 snRNA binding [PMID:17631273]" /experiment="EXISTENCE:direct assay:GO:0031428 box C/D methylation guide snoRNP complex [PMID:11081632]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:17631273]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:11720284|PMID:14730029]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14730029]" /experiment="EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:14730029]" /note="RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein" /db_xref="GeneID:856687" /db_xref="SGD:S000000752" ORIGIN 1 msapnpkafp ladaaltqqi ldvvqqaanl rqlkkganea tktlnrgise fiimaadcep 61 ieillhlpll cedknvpyvf vpsrvalgra cgvsrpviaa sittndasai ktqiyavkdk 121 ietlli // LOCUS NP_010889 1188 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL025C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010889 VERSION NP_010889.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178840.1 REFERENCE 1 (residues 1 to 1188) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1188) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1188) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1188) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07627. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1188 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1188 /product="uncharacterized protein" /calculated_mol_wt="135939" CDS 1..1188 /locus_tag="YEL025C" /coded_by="NM_001178840.1:1..3567" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /db_xref="GeneID:856688" /db_xref="SGD:S000000751" ORIGIN 1 marqdetdck kldsnsaflp lcitsyrskd eaeklvsclh hegsyflcfs yglytgtsne 61 lkakvefald gpfvvnyatv pmfmsasfch llmfndgsik gfkcennkfe iiydsnvapk 121 ldtislltss wlnasfegvl ytcnknisyd sdlhtlctti ysfdfregiv erfyatdgee 181 iisfdfisre dllddatctg kshvyflcll kscysenlfl keynlagkhg srkfdlneyr 241 qynllpicdn efcymkvvcg htivvlttny tqiinikasg ltngaffnnk glpnvenyqf 301 lkdsydviye rsvilltisd vyankytaki htrslhrdhv lkelqwtker vfkppkhdlc 361 dvilqlprek yiavtringv nfiskdhrgs klekvksgpa ytnkvylasq vignkgtdid 421 slllggsfns rrgflekkil vydktlfklv tsskalvenv tdfwvtdlal nggdefayes 481 ggliykngif lmdepydygl fvsrtgkvlk agmdgstgef rqvdflqsnh nsstmfcypv 541 qnsklrisil eaksgflrkk eeffihglns kesivscfsd gaekylfviy ldgvfsvwna 601 nqkkvatshp dysfiaydql ikiswlskkh khdsiyvias sytgcvrvyk sesnflrvdl 661 eihslydqkl elldtipslp lvflyndkei illnlqnmsy gciqlglvpr rmrirpgkal 721 fslcvldyds risifefgst fyregftkqm tslkpqlenh ifylpsipve lytvpnnlnq 781 avvclvdsns rqyklmlfny asmkavstfs fsdekylhav vkplwpeqns iylsqrpfyg 841 nkfvvclgvg ekrtkfwlfe irnnnitqly anyledcifs vfiyyecnlv lfsgdsgiaa 901 ykinmlkega eileaysfpa lssinhiglp aymsgdylvq feilrdflrt rfpirtsivy 961 pseypecpyl gfkrlgsitq vatkiipkkl repkndclas dknyllgrls dlscatlkys 1021 nrsyvatigi dntltiyeds klsvdkggla mpylkirlpn kiislaaipd gfqnlqicpn 1081 fnsqrlegvi plfllcgteg qiyiisefig elwmrtlhdy kkikleckra frrseksmrn 1141 vtkqysvske tginesgfde larnskrrhi dhspyktidf fdpvklkr // LOCUS NP_010890 215 aa linear PLN 30-JUN-2025 DEFINITION ubiquinol--cytochrome-c reductase catalytic subunit RIP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010890 VERSION NP_010890.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178839.3 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07628. On Jul 30, 2012 this sequence version replaced NP_010890.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..215 /product="ubiquinol--cytochrome-c reductase catalytic subunit RIP1" /EC_number="7.1.1.8" /calculated_mol_wt="23234" Region 32..87 /region_name="UCR_TM" /note="Ubiquinol cytochrome reductase transmembrane region; pfam02921" /db_xref="CDD:460747" Region 93..214 /region_name="Rieske_cytochrome_bc1" /note="Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; cd03470" /db_xref="CDD:239552" Site order(159,161..162,178,181,183) /site_type="other" /note="[2Fe-2S] cluster binding site [ion binding]" /db_xref="CDD:239552" CDS 1..215 /gene="RIP1" /locus_tag="YEL024W" /coded_by="NM_001178839.3:1..648" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:3036836]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:10873857]" /experiment="EXISTENCE:mutant phenotype:GO:0008121 quinol-cytochrome-c reductase activity [PMID:2537289]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:3036836]" /experiment="EXISTENCE:mutant phenotype:GO:0045275 respiratory chain complex III [PMID:3036836]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="Ubiquinol-cytochrome-c reductase; a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration; during import, Rip1p is first imported into the mitochondrial matrix where it is processed, acquires its Fe-S cluster, and is folded, then is translocated into the inner membrane by the action of a homo-oligomer of Bcs1p, and finally is delivered by Bcs1p to Complex III for assembly" /db_xref="GeneID:856689" /db_xref="SGD:S000000750" ORIGIN 1 mlgirssvkt cfkpmsltsk rlisqsllas kstyrtpnfd dvlkenndad kgrsyayfmv 61 gamgllssag akstvetfis smtatadvla makvevnlaa iplgknvvvk wqgkpvfirh 121 rtpheiqean svdmsalkdp qtdadrvkdp qwlimlgict hlgcvpigea gdfggwfcpc 181 hgshydisgr irkgpaplnl eipayefdgd kvivg // LOCUS NP_010891 682 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL023C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010891 VERSION NP_010891.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178838.1 REFERENCE 1 (residues 1 to 682) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 682) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 682) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 682) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07629. Method: conceptual translation. FEATURES Location/Qualifiers source 1..682 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..682 /product="uncharacterized protein" /calculated_mol_wt="78189" Region 32..416 /region_name="DUF2235" /note="Uncharacterized alpha/beta hydrolase domain (DUF2235); pfam09994" /db_xref="CDD:462937" CDS 1..682 /locus_tag="YEL023C" /coded_by="NM_001178838.1:1..2049" /note="hypothetical protein; expression is increased greatly during sporulation; YEL023C is not an essential gene" /db_xref="GeneID:856690" /db_xref="SGD:S000000749" ORIGIN 1 mdsfnyihgk ykkngtggdr sinpsshsss gkniilcfdg trenfgpqpf tnilklynll 61 engdsseqic yyqpgigsvg fdavvdvrrr ltishlqnll dsmfafsldn hicsaylflm 121 kyfepgdriy mfgfsrgafi arvlagmier vgllskglee mvkmawqiye kweydsqpne 181 lqytstlaee fkktfsrdye vkihfqglfd svnsvgilrd rlfpctqrsn ivehvrhcvs 241 lderrgkfkq lcftpmpyip klfsltycnh itdqcspvpt snalmrdltp enplikytlk 301 sgahsisnps plipdnpgrl lsskseette llldlnsfle gnsyardtec strgieaifq 361 lqsiqgsgts srmtmtpdli ekwfpgdhsd vgggwapdce teenlsnltl rwilaeaikf 421 gvkfkpgaih dfatkhtsig slfadthdyl sfnspkkcsl lgvsdnedga redksgrner 481 medclknike trlslkdeke kvkdaftlkc ghankfmrlv wwvlellpig irmenkegkw 541 qnfhtpnlgr sryvpeyvsl hwsvywrikf drryrpdnmp eyvrqlfqdl egidlksnkv 601 snkydkqdns ngseinggff dneegqelhm gqkasyfatt ynsrlfdsky sqlkkkfmdw 661 dsnswtdipd dlkiylqqde sl // LOCUS NP_010892 1459 aa linear PLN 30-JUN-2025 DEFINITION Arf family guanine nucleotide exchange factor GEA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010892 VERSION NP_010892.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178837.1 REFERENCE 1 (residues 1 to 1459) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1459) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1459) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1459) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07630. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1459 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1459 /product="Arf family guanine nucleotide exchange factor GEA2" /calculated_mol_wt="165537" Region 350..489 /region_name="Sec7_N" /note="Guanine nucleotide exchange factor in Golgi transport N-terminal; pfam12783" /db_xref="CDD:463703" Region 559..756 /region_name="Sec7" /note="Sec7 domain; pfam01369" /db_xref="CDD:460178" CDS 1..1459 /gene="GEA2" /locus_tag="YEL022W" /coded_by="NM_001178837.1:1..4380" /experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:11294905]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10430582]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11294905]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:14668359]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11493664]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11493664]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20444982]" /experiment="EXISTENCE:mutant phenotype:GO:0033363 secretory granule organization [PMID:14734650]" /note="Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication" /db_xref="GeneID:856691" /db_xref="SGD:S000000748" ORIGIN 1 msdrefvtvd pvtiiikeci nlstamrkys kftsqsgvaa llgggseifs nqddylahtf 61 nnlntnkhnd pflsgfiqlr lmlnklknld nidsltilqp fllivstssi sgyitslald 121 slqkfftlni inessqnyig ahratvnalt hcrfegsqql sddsvllkvv fllrsivdsp 181 ygdllsnsii ydvlqtilsl acnnrrsevl rnaaqstmia vtvkifsklk tiepvnvnqi 241 yindesytnd vlkadtigtn veskeegsqe dpigmkvnne eaiseddgie eehihsekst 301 ngaeqldivq kttrsnsriq ayaddnyglp vvrqylnlll sliapenelk hsystrifgl 361 eliqtaleis gdrlqlyprl ftlisdpifk silfiiqntt klsllqatlq lfttlvvilg 421 nnlqlqielt ltrifsilld dgtannssse nknkpsiike llieqisilw trspsfftst 481 finfdcnldr advsinflka ltklalpesa ltttesvppi cleglvslvd dmfdhmkdid 541 reefgrqkne meilkkrdrk tefiectnaf nekpkkgipm liekgfiasd sdkdiaeflf 601 nnnnrmnkkt iglllchpdk vsllneyirl fdfsglrvde airilltkfr lpgesqqier 661 iieafssayc enqdydpski sdnaeddist vqpdadsvfi lsysiimlnt dlhnpqvkeh 721 msfedysgnl kgccnhkdfp fwyldriycs irdkeivmpe ehhgnekwfe dawnnlisst 781 tviteikkdt qsvmdkltpl ellnfdraif kqvgpsivst lfniyvvasd dhistrmits 841 ldkcsyisaf fdfkdlfndi lnsiakgttl insshddels tlafeygpmp lvqikfedtn 901 teipvstdav rfgrsfkgql ntvvffriir rnkdpkifsk elwlnivnii ltlyedlils 961 pdifpdlqkr lklsnlpkps peisinkske skgllstfas ylkgdeepte eeiksskkam 1021 ecikssniaa svfgnesnit adliktllds akteknadns ryfeaellfi ieltialflf 1081 ckeekelgkf ilqkvfqlsh tkgltkrtvr rmltykilli slcadqteyl sklindellk 1141 kgdiftqkff atnqgkeflk rlfsltesef yrgfllgnen fwkflrkvta mkeqsesife 1201 ylnesiktds niltnenfmw vlglldeiss mgavgnhwei eykkltesgh kidkenpykk 1261 sielslksiq ltshllednn dlrkneifai iqalahqcin pckqisefav vtleqtlink 1321 ieiptnemes veelieggll pllnssetqe dqkilissil tiisnvylhy lklgktsnet 1381 flkilsifnk fvedsdiekk lqqlildkks iekgngsssh gsaheqtpes ndveieatap 1441 iddntdddnk pklsdvekd // LOCUS NP_010893 267 aa linear PLN 30-JUN-2025 DEFINITION orotidine-5'-phosphate decarboxylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010893 VERSION NP_010893.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178836.3 REFERENCE 1 (residues 1 to 267) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 267) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 267) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 267) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07631. On Jul 30, 2012 this sequence version replaced NP_010893.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..267 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..267 /product="orotidine-5'-phosphate decarboxylase" /EC_number="4.1.1.23" /calculated_mol_wt="29108" Region 32..252 /region_name="TIM-like beta/alpha barrel domains" /note="A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure; cl21457" /db_xref="CDD:473867" Site order(35,37,59,61,91,93,153..154,202,234..235) /site_type="active" /db_xref="CDD:240076" Site order(61,63..64,92..93,95..96,99..100,103..104,122..124, 135,153,164,235) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:240076" CDS 1..267 /gene="URA3" /locus_tag="YEL021W" /coded_by="NM_001178836.3:1..804" /experiment="EXISTENCE:direct assay:GO:0004590 orotidine-5'-phosphate decarboxylase activity [PMID:2061334]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18812321]" /experiment="EXISTENCE:direct assay:GO:0006222 UMP biosynthetic process [PMID:2061334]" /experiment="EXISTENCE:mutant phenotype:GO:0004590 orotidine-5'-phosphate decarboxylase activity [PMID:4550660|PMID:5651325]" /experiment="EXISTENCE:mutant phenotype:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:4550660|PMID:5651325]" /experiment="EXISTENCE:mutant phenotype:GO:0006222 UMP biosynthetic process [PMID:5651325|PMID:4550660]" /note="Orotidine-5'-phosphate (OMP) decarboxylase; catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound" /db_xref="GeneID:856692" /db_xref="SGD:S000000747" ORIGIN 1 mskatykera athpspvaak lfnimhekqt nlcasldvrt tkellelvea lgpkicllkt 61 hvdiltdfsm egtvkplkal sakynfllfe drkfadignt vklqysagvy riaewaditn 121 ahgvvgpgiv sglkqaaeev tkeprgllml aelsckgsla tgeytkgtvd iaksdkdfvi 181 gfiaqrdmgg rdegydwlim tpgvglddkg dalgqqyrtv ddvvstgsdi iivgrglfak 241 grdakveger yrkagweayl rrcgqqn // LOCUS NP_010894 87 aa linear PLN 30-JUN-2025 DEFINITION protein transporter TIM9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010894 VERSION NP_010894.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184349.1 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07632. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..87 /product="protein transporter TIM9" /calculated_mol_wt="10070" Region 13..76 /region_name="zf-Tim10_DDP" /note="Tim10/DDP family zinc finger; pfam02953" /db_xref="CDD:460764" CDS 1..87 /gene="TIM9" /locus_tag="YEL020W-A" /coded_by="NM_001184349.1:1..264" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0042719 mitochondrial intermembrane space protein transporter complex [PMID:9889188|PMID:9822593]" /experiment="EXISTENCE:direct assay:GO:0042721 TIM22 mitochondrial import inner membrane insertion complex [PMID:9495346]" /experiment="EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9822593|PMID:10469659]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:12138093]" /experiment="EXISTENCE:direct assay:GO:0140318 protein transporter activity [PMID:9822593]" /experiment="EXISTENCE:genetic interaction:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9822593]" /experiment="EXISTENCE:genetic interaction:GO:0140318 protein transporter activity [PMID:9822593]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9889188]" /note="Essential protein of the mitochondrial intermembrane space; forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane" /db_xref="GeneID:856693" /db_xref="SGD:S000007256" ORIGIN 1 mdalnskeqq efqkvveqkq mkdfmrlysn lvercftdcv ndfttskltn keqtcimkcs 61 ekflkhserv gqrfqeqnaa lgqglgr // LOCUS NP_010895 560 aa linear PLN 30-JUN-2025 DEFINITION putative indolepyruvate decarboxylase family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010895 VERSION NP_010895.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178835.1 REFERENCE 1 (residues 1 to 560) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 560) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 560) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 560) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07633. Method: conceptual translation. FEATURES Location/Qualifiers source 1..560 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..560 /product="putative indolepyruvate decarboxylase family protein" /EC_number="4.1.2.63" /calculated_mol_wt="61158" Region 13..544 /region_name="PRK09259" /note="putative oxalyl-CoA decarboxylase; Validated" /db_xref="CDD:236433" CDS 1..560 /gene="PXP1" /locus_tag="YEL020C" /coded_by="NM_001178835.1:1..1683" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:26928762|PMID:27392156]" /note="Peroxisomal matrix protein; well-conserved in fungi; contains tripartite homology domain of thiamine pyrophosphate (TPP) enzymes; targeted to peroxisomes by Pex5p; contains low sequence identity with Pdc1p; mRNA identified as translated by ribosome profiling data" /db_xref="GeneID:856694" /db_xref="SGD:S000000746" ORIGIN 1 mtttatqhfa qllqkygidt vfgivgipiv qladtmvang ikfipcrneq aasyaasayg 61 yisdkpgvll ivggpgliha lagiynsmsn rwpllviags ssqsdihkgg fqeldqvsll 121 spflkftgkl tpdnidmitq kalnyciqgt agvsyidvpa dfieyekple gndrtgnelp 181 miltpnicgp dpskikkvvq lilqhknkni livigkgavk nsheirrlvn tfnlpflptp 241 makgivpdss plnvssarsq alkiadivlv lgarlnwilh fgtspkwnse sifiqfdsnp 301 etlgdnnvsp gadlsiwgdi glsvtalvee ltrqdscwky sgvkqeirek iqlnqtrllr 361 kektrgaqln ynqvygtlrp liddyrtilv tegantmdia risfptdapr rrldagtnat 421 mgiglgyala ckashpeldv vliqgdsafg fsameietav rcqlalvivv mnnsgiyhge 481 kdiegdlppt alskncrydl vgkglgandf fvntiselsr cfqqavqlsr tkretsvinv 541 iiepgeqkqi afawqnkprl // LOCUS NP_010896 267 aa linear PLN 30-JUN-2025 DEFINITION SUMO ligase MMS21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010896 VERSION NP_010896.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178834.3 REFERENCE 1 (residues 1 to 267) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 267) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 267) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 267) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07634. On Jul 30, 2012 this sequence version replaced NP_010896.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..267 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..267 /product="SUMO ligase MMS21" /calculated_mol_wt="30223" Region 1..267 /region_name="COG5627" /note="SUMO ligase MMS21, Smc5/6 complex, required for cell growth and DNA repair [Replication, recombination and repair]" /db_xref="CDD:227914" CDS 1..267 /gene="MMS21" /locus_tag="YEL019C" /gene_synonym="NSE2; PSO10" /coded_by="NM_001178834.3:1..804" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:31765407|PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:7788712|PMID:15738391]" /experiment="EXISTENCE:mutant phenotype:GO:0019789 SUMO transferase activity [PMID:31765407|PMID:15738391|PMID:24108357]" /experiment="EXISTENCE:mutant phenotype:GO:0030291 protein serine/threonine kinase inhibitor activity [PMID:24108357]" /experiment="EXISTENCE:mutant phenotype:GO:1990683 DNA double-strand break attachment to nuclear envelope [PMID:27056668]" /note="Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex; required for anchoring dsDNA breaks to the nuclear periphery; SMC5-SMC6 plays a key role in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; required for efficient sister chromatid cohesion; mutants are sensitive to MMS, show increased spontaneous mutation and mitotic recombination; SUMOylates and inhibits Snf1p function; supports nucleolar function" /db_xref="GeneID:856695" /db_xref="SGD:S000000745" ORIGIN 1 malndnpipk svplhpksgk yfhnlhardl sniyqqcykq idetinqlvd stspstigie 61 eqvaditsty kllstyeses nsfdehikdl kknfkqssda cpqidlstwd kyrtgeltap 121 klselylnmp tpepatmvnn tdtlkilkvl pyiwndptcv ipdlqnpade ddlqieggki 181 eltcpitckp yeaplisrkc nhvfdrdgiq nylqgyttrd cpqaacsqvv smrdfvrdpi 241 melrckiakm kesqeqdkrs sqaidvl // LOCUS NP_010897 279 aa linear PLN 30-JUN-2025 DEFINITION Eaf5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010897 VERSION NP_010897.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178833.1 REFERENCE 1 (residues 1 to 279) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 279) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 279) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 279) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07635. Method: conceptual translation. FEATURES Location/Qualifiers source 1..279 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..279 /product="Eaf5p" /calculated_mol_wt="31513" CDS 1..279 /gene="EAF5" /locus_tag="YEL018W" /coded_by="NM_001178833.1:1..840" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]" /note="Non-essential subunit of the NuA4 acetyltransferase complex; Esa1p-associated factor; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:856696" /db_xref="SGD:S000000744" ORIGIN 1 mdkevselvv lqlihtlisn kneelvrngg ginmignnlr islvkltnei qnnllinelt 61 nlrrqsnvan gnrklgindi ltivknlfpe yrttlndgql slhglemhdi eklldekydr 121 fkktqveqir mmedeilkng iktgasqlqp hanagksgsa gtsatitttt phmahsmdpk 181 rekllklyrd tvlnkleskt gnfqklfksp dgsiiknein yediknetpg svhelqlilq 241 ksitdgvmrk vigtddwkla rqvqfelddt vqfmrrale // LOCUS NP_010898 43 aa linear PLN 30-JUN-2025 DEFINITION proteolipid ATPase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010898 VERSION NP_010898.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180029.1 REFERENCE 1 (residues 1 to 43) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 43) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 43) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 43) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07636. Method: conceptual translation. FEATURES Location/Qualifiers source 1..43 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..43 /product="proteolipid ATPase" /calculated_mol_wt="4717" Region 1..43 /region_name="PMP1_2" /note="ATPase proteolipid family; pfam08114" /db_xref="CDD:285351" CDS 1..43 /gene="PMP2" /locus_tag="YEL017C-A" /coded_by="NM_001180029.1:1..132" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:8063750]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0005886 plasma membrane [PMID:8063750]" /experiment="EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:8063750]" /experiment="EXISTENCE:genetic interaction:GO:0032781 positive regulation of ATP-dependent activity [PMID:8063750]" /note="Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication" /db_xref="GeneID:856697" /db_xref="SGD:S000002103" ORIGIN 1 mlmstlpggv ilvfilvgla ciaiistiiy rkwqarqrgl qrf // LOCUS NP_010899 337 aa linear PLN 30-JUN-2025 DEFINITION Gtt3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010899 VERSION NP_010899.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178832.3 REFERENCE 1 (residues 1 to 337) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 337) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 337) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 337) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07637. On Jul 30, 2012 this sequence version replaced NP_010899.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..337 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..337 /product="Gtt3p" /calculated_mol_wt="38104" CDS 1..337 /gene="GTT3" /locus_tag="YEL017W" /coded_by="NM_001178832.3:1..1014" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /note="hypothetical protein may be involved in glutathione metabolism; function suggested by computational analysis of large-scale protein-protein interaction data; N- and C-terminal fusion proteins localize to the cell periphery" /db_xref="GeneID:856698" /db_xref="SGD:S000000743" ORIGIN 1 mptkstfsrw kkadlidlan kleidgfpny akksdmidyl eshlnhlekp vdfkddypel 61 rsfyesmtvd qskderneyg sgsgngsgsg scdtatndsd lekayikedd dekpqsgdet 121 satkplssrn ansnaktnfn lldfstdnds stsaftkfkf nfqeylsdir yqtqklnenv 181 qdylstisav dtifsllefs flvrnilaag qptsssslas sleaavaahn kyqytldfcl 241 piltwllffr giptlvsyyi nfirydlnie ldpmtfnltk flislaifkt cnnknidfhs 301 frcvnqlwtq lctvnrslgm vplvfsmvsc lltlyvl // LOCUS NP_010900 493 aa linear PLN 30-JUN-2025 DEFINITION nucleotide diphosphatase/phosphodiesterase NPP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010900 VERSION NP_010900.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178831.1 REFERENCE 1 (residues 1 to 493) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 493) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 493) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 493) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07638. Method: conceptual translation. FEATURES Location/Qualifiers source 1..493 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..493 /product="nucleotide diphosphatase/phosphodiesterase NPP2" /EC_number="3.1.4.1" /EC_number="3.6.1.9" /calculated_mol_wt="57224" Region 78..481 /region_name="Enpp" /note="Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin; cd16018" /db_xref="CDD:293742" Site order(84,126..127,148,257,261,306..307,435) /site_type="active" /db_xref="CDD:293742" Site order(84,126..127,148,257,261,307,435) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:293742" Site 460..462 /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:293742" CDS 1..493 /gene="NPP2" /locus_tag="YEL016C" /coded_by="NM_001178831.1:1..1482" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]" /experiment="EXISTENCE:genetic interaction:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:16278456]" /experiment="EXISTENCE:genetic interaction:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0009141 nucleoside triphosphate metabolic process [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:16278456]" /experiment="EXISTENCE:mutant phenotype:GO:0047429 nucleoside triphosphate diphosphatase activity [PMID:16278456]" /note="Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; NPP2 has a paralog, NPP1, that arose from the whole genome duplication; npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to single mutants" /db_xref="GeneID:856699" /db_xref="SGD:S000000742" ORIGIN 1 mllfeqpvdl eknneddtni kpfaisrhfl lklllcgiil ielllyskcp kpidngprti 61 anrsntyfng thdfktltil isidgfhprl idakytpfly nlhnlrspyd mnittapymi 121 psfptqtfpn hwsmvtgkyp iehgivsnif wdnftssefr pnnldariws ntadpiwqll 181 qtesqgeykv athmwpgsev vyedhgdvpr ermpfyfgkf nqweklqdkl aqifryidmp 241 qlkdrpelvi syipnvdsyg hsfgydlrdk rlqkligevd gffldliegl qkrnllkisn 301 vmivsdhgms nvnandgehv vvwervfpad amsafishly negpmmmvcl knprdkqwic 361 dlieaqleka ygdeisrkfh vilkedfdps wkyfqydnrk hryddrvgdi wiladeyyai 421 vkemgdvpig imgthgynfn ncsdmasifi gmgpmfnnev vppfenievy nmlikasall 481 geektkkeks llq // LOCUS NP_010901 551 aa linear PLN 30-JUN-2025 DEFINITION Edc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010901 VERSION NP_010901.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178830.1 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07639. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..551 /product="Edc3p" /calculated_mol_wt="61209" Region 4..63 /region_name="Edc3_Lsm" /note="Lsm domain of enhancer of mRNA-decapping protein 3 (Edc3) and similar proteins; cd22576" /db_xref="CDD:439343" Site order(4,23,27..28,31,51..52,54..55,57..60,62) /site_type="other" /note="Dcp2 binding site [polypeptide binding]" /db_xref="CDD:439343" Region 99..202 /region_name="FDF" /note="FDF domain; pfam09532" /db_xref="CDD:430668" Region 305..498 /region_name="YjeF_N" /note="YjeF-related protein N-terminus; pfam03853" /db_xref="CDD:427546" CDS 1..551 /gene="EDC3" /locus_tag="YEL015W" /gene_synonym="DCP3; LSM16" /coded_by="NM_001178830.1:1..1656" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:15020463]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:24492965]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:23706738]" /experiment="EXISTENCE:genetic interaction:GO:0033962 P-body assembly [PMID:18981231]" /experiment="EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15225544]" /experiment="EXISTENCE:mutant phenotype:GO:0033962 P-body assembly [PMID:18981231|PMID:17984320]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:23956223|PMID:24492965]" /note="Non-essential conserved protein with a role in mRNA decapping; specifically affects the function of the decapping enzyme Dcp1p; mediates decay of the RPS28B mRNA via binding to both Rps28Bp (or Rps28Ap) and the RPS28B mRNA; mediates decay of the YRA1 mRNA by a different, translation-independent mechanism; localizes to cytoplasmic mRNA processing bodies; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:856700" /db_xref="SGD:S000000741" ORIGIN 1 msqfvgfgvq velkdgkliq gkiakatskg ltlndvqfgd ggksqafkvr asrlkdlkvl 61 tvasqsgkrk qqrqqqqqnd ynqnrgehid wqdddvskik qqedfdfqrn lgmfnkkdvf 121 aqlkqnddil penrlqghnr kqtqlqqnny qndelvipda kkdswnkiss rneqsthqsq 181 pqqdaqddlv leddeheydv ddiddpkylp itqslnithl ihsatnspsi ndktkgtvin 241 dkdqvlaklg qmiisqsrsn stslpaankq ttirskntkq nipmatpvql lemesitsef 301 fsinsaglle nfavnasffl kqklggrarl rlqnsnpepl vvilasdsnr sgakalalgr 361 hlcqtghirv itlftcsqne lqdsmvkkqt diykkcggki vnsvsslesa metlnspvei 421 vidamqgydc tlsdlagtse viesriksmi swcnkqrgst kvwsldipng fdagsgmpdi 481 ffsdrieatg iicsgwplia innlianlps ledavlidig ipqgaysqrt slrkfqncdl 541 fvtdgsllld l // LOCUS NP_001335765 101 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL014C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335765 VERSION NP_001335765.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348821.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80285. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..101 /product="uncharacterized protein" /calculated_mol_wt="12078" CDS 1..101 /locus_tag="YEL014C" /coded_by="NM_001348821.1:1..306" /note="hypothetical protein; conserved among S. cerevisiae strains" /db_xref="GeneID:856701" /db_xref="SGD:S000000740" ORIGIN 1 mtalfclelr tniflimndc iiinywkgfi fsfhsyffpf rfesslrahy pgkrnysdfs 61 viplpyyidv rsfhicesqh iialplqipl pyrmlirmyp v // LOCUS NP_010903 578 aa linear PLN 30-JUN-2025 DEFINITION protein anchor VAC8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010903 VERSION NP_010903.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178828.3 REFERENCE 1 (residues 1 to 578) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 578) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 578) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 578) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07640. On Jul 30, 2012 this sequence version replaced NP_010903.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..578 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..578 /product="protein anchor VAC8" /calculated_mol_wt="63077" Region 42..>358 /region_name="SRP1" /note="Karyopherin (importin) alpha [Intracellular trafficking and secretion]; COG5064" /db_xref="CDD:227396" Site order(103,107,111,144,148,152,185,189,193) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293788" Region 119..155 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 160..194 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 204..235 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Site order(226,230,234,269,273,277,310,314,318) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293788" Region 242..280 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 286..319 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 326..361 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 369..402 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" CDS 1..578 /gene="VAC8" /locus_tag="YEL013W" /gene_synonym="YEB3" /coded_by="NM_001178828.3:1..1737" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:9739084|PMID:9490720|PMID:9664035|PMID:26928762|PMID :16301533]" /experiment="EXISTENCE:direct assay:GO:0000425 pexophagy [PMID:31262095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006914 autophagy [PMID:31262095]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:10888680]" /experiment="EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:10888680]" /experiment="EXISTENCE:direct assay:GO:0034517 ribophagy [PMID:31262095]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:10888680]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:10888680]" /experiment="EXISTENCE:direct assay:GO:0071563 Myo2p-Vac17p-Vac8p transport complex [PMID:12529432]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:8885233|PMID:16301533|PMID:10888680]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:31649143]" /experiment="EXISTENCE:mutant phenotype:GO:0000407 phagophore assembly site [PMID:31649143]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:15901835]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:34893607]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:32508216|PMID:34893607]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:12529432|PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:16301533|PMID:11441010]" /experiment="EXISTENCE:mutant phenotype:GO:0043495 protein-membrane adaptor activity [PMID:12594460]" /experiment="EXISTENCE:mutant phenotype:GO:0051656 establishment of organelle localization [PMID:32508216]" /experiment="EXISTENCE:mutant phenotype:GO:0071255 Cvt vesicle assembly [PMID:10837477]" /experiment="EXISTENCE:mutant phenotype:GO:0071562 nucleus-vacuole junction assembly [PMID:10888680]" /experiment="EXISTENCE:mutant phenotype:GO:1903044 protein localization to membrane raft [PMID:10888680]" /experiment="EXISTENCE:physical interaction:GO:0043495 protein-membrane adaptor activity [PMID:12594460]" /experiment="EXISTENCE:physical interaction:GO:0071561 nucleus-vacuole junction [PMID:10888680]" /experiment="EXISTENCE:physical interaction:GO:0071563 Myo2p-Vac17p-Vac8p transport complex [PMID:12594460|PMID:12529432]" /note="Vacuole-specific Myo2p receptor; Myo2p-Vac17p-Vac8p transport complex subunit required for vacuolar inheritance; mediates anchoring of phosphatidylinositol 3-kinase complex I (PIK3C3-C1) to autophagosome; required with Atg13p for the vesicle closure step of the cytoplasm-to-vacuole (CVT) pathway, for homotypic vacuole-vacuole fusion and for nucleus-vacuole junction formation with Nvj1p; contains 11 armadillo (ARM) repeats; myristoylated, palmitoylated, and phosphorylated" /db_xref="GeneID:856702" /db_xref="SGD:S000000739" ORIGIN 1 mgsccsclkd ssdeasvspi adnereavtl llgyledkdq ldfysggplk alttlvysdn 61 lnlqrsaala faeitekyvr qvsrevlepi lillqsqdpq iqvaacaalg nlavnnenkl 121 livemgglep linqmmgdnv evqcnavgci tnlatrddnk hkiatsgali pltklakskh 181 irvqrnatga llnmthseen rkelvnagav pvlvsllsst dpdvqyyctt alsniavdea 241 nrkklaqtep rlvsklvslm dspssrvkcq atlalrnlas dtsyqleivr agglphlvkl 301 iqsdsiplvl asvacirnis ihplnegliv dagflkplvr lldykdseei qchavstlrn 361 laasseknrk effesgavek ckelaldspv svqseisacf ailaladvsk ldlleanild 421 alipmtfsqn qevsgnaaaa lanlcsrvnn ytkiieawdr pnegirgfli rflksdyatf 481 ehialwtilq lleshndkve dlvkndddii ngvrkmadvt ferlqrsgid vknpgsnnnp 541 ssndnnsnnn dtgsehqpve daslelynit qqilqflh // LOCUS NP_010904 218 aa linear PLN 30-JUN-2025 DEFINITION E2 ubiquitin-conjugating protein UBC8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010904 VERSION NP_010904.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178827.1 REFERENCE 1 (residues 1 to 218) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 218) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 218) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 218) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07641. On Dec 15, 1999 this sequence version replaced NP_010904.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..218 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..218 /product="E2 ubiquitin-conjugating protein UBC8" /EC_number="2.3.2.23" /calculated_mol_wt="24502" Region 6..143 /region_name="UBCc_UBE2H" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 H and related proteins; cd23797" /db_xref="CDD:467417" CDS 1..218 /gene="UBC8" /locus_tag="YEL012W" /gene_synonym="GID3" /coded_by="NM_001178827.1:1..657" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:1869573]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10811607]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10811607]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:36253107]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]" /note="Ubiquitin-conjugating enzyme that regulates gluconeogenesis; negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro" /db_xref="GeneID:856704" /db_xref="SGD:S000000738" ORIGIN 1 mssskrriet dvmkllmsdh qvdlindsmq efhvkflgpk dtpyengvwr lhvelpdnyp 61 ykspsigfvn kifhpnidia sgsicldvin stwsplydli nivewmipgl lkepngsdpl 121 nneaatlqlr dkklyeekik eyidkyatke kyqqmfggdn dsddsdsggd lqeedsdsde 181 dmdgtgvssg ddsvdelsed lsdidvsddd dydevanq // LOCUS NP_010905 704 aa linear PLN 30-JUN-2025 DEFINITION 1,4-alpha-glucan branching enzyme [Saccharomyces cerevisiae S288C]. ACCESSION NP_010905 VERSION NP_010905.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178826.1 REFERENCE 1 (residues 1 to 704) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 704) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 704) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 704) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07642. Method: conceptual translation. FEATURES Location/Qualifiers source 1..704 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..704 /product="1,4-alpha-glucan branching enzyme" /EC_number="2.4.1.18" /calculated_mol_wt="80985" Region 9..702 /region_name="PLN02447" /note="1,4-alpha-glucan-branching enzyme" /db_xref="CDD:215246" CDS 1..704 /gene="GLC3" /locus_tag="YEL011W" /gene_synonym="GHA1" /coded_by="NM_001178826.1:1..2115" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0003844 1,4-alpha-glucan branching enzyme activity [PMID:1729600]" /experiment="EXISTENCE:mutant phenotype:GO:0005978 glycogen biosynthetic process [PMID:1729600]" /note="Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress; glycogen accumulation defect of the null mutant is functionally complemented by human GBE1, which is associated with glycogen storage disease" /db_xref="GeneID:856705" /db_xref="SGD:S000000737" ORIGIN 1 mynipdnvkg avefdpwlkp fadvlserry ladkwlydit hatpdgsyqs lskfardsyk 61 syglhanpet keitykewap naeraflvgd fnnwdttshe lknkdefgnf titlhplpng 121 dfaiphdski kvmfilpdgs kifrlpawit ratqpskets kqfgpayegr fwnpenpykf 181 vhprpkfses vdslriyeah vgisspepki ttykeftekv lprikylgyd aiqlmaimeh 241 ayyasfgyqv tnffaassrf gtpeelkeli dtahsmgilv lldvvhshas knvedglnmf 301 dgsdhqyfhs issgrgehpl wdsrlfnygk fevqrfllan lafyvdvyqf dgfrfdgvts 361 mlyvhhgvga ggsfsgdyne ylsrdrsfvd healaylmla ndlvhemlpn lavtvaedvs 421 gyptlclprs iggtgfdyrl amalpdmwik likekkddew emgsivytlt nrrygekvva 481 yceshdqalv gdktlafwlm daamytdmtv lkepsividr gialhkmirl ithslggeay 541 lnfegnefgh pewldfpnvn ngdsykyarr qfnladdpll ryqnlnefdr smqlcekrhk 601 wlntkqayvs lkhegdkmiv fernnllfif nfhptnsysd yrvgvekagt yhivlnsdra 661 efgghnrine sseffttdle wnnrknflqv yipsrvalvl alke // LOCUS NP_001335766 135 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL009C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335766 VERSION NP_001335766.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348822.1 REFERENCE 1 (residues 1 to 135) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 135) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 135) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 135) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80286. Method: conceptual translation. FEATURES Location/Qualifiers source 1..135 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..135 /product="uncharacterized protein" /calculated_mol_wt="15808" CDS 1..135 /locus_tag="YEL009C-A" /coded_by="NM_001348822.1:1..408" /note="hypothetical protein; conserved among S. cerevisiae strains; overlaps ORF YEL010W" /db_xref="GeneID:31009438" /db_xref="SGD:S000028741" ORIGIN 1 mntllkkyrk qryawlrfll fskiegslpv alrillslqp fccniyrkyy qenkkvksts 61 gntalkiiek leslvsnlrl kysqmfsllf lhsynclqsl atetfriikk reknllslli 121 pgscieiarh fvlke // LOCUS NP_010907 281 aa linear PLN 30-JUN-2025 DEFINITION amino acid starvation-responsive transcription factor GCN4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010907 VERSION NP_010907.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178824.3 REFERENCE 1 (residues 1 to 281) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 281) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 281) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 281) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07643. On Jul 30, 2012 this sequence version replaced NP_010907.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..281 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..281 /product="amino acid starvation-responsive transcription factor GCN4" /calculated_mol_wt="31179" Region 106..134 /region_name="GCN4_cent" /note="GCN4 central activation domain-like acidic activation domain; cd12192" /db_xref="CDD:213399" Site order(111,113..114,120..121,123..125,127..128,132..134) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:213399" Region 226..278 /region_name="bZIP_GCN4" /note="Basic leucine zipper (bZIP) domain of General control protein GCN4: a DNA-binding and dimerization domain; cd12193" /db_xref="CDD:269833" Region 227..278 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269833" Site order(231..232,234..236,238..243,245) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269833" Site order(253,257,260..261,263..264,267..268,270..271,274..275, 277..278) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269833" CDS 1..281 /gene="GCN4" /locus_tag="YEL009C" /gene_synonym="AAS101; AAS3; ARG9" /coded_by="NM_001178824.3:1..846" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:19940160]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18794364]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:16581788]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12455686|PMID:14648200]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:3530496|PMID:2204805|PMID:3464968|PMID:3290651|PMID: 3907851|PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:18794364]" /experiment="EXISTENCE:genetic interaction:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:15121833]" /experiment="EXISTENCE:genetic interaction:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:1425591]" /experiment="EXISTENCE:genetic interaction:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:6351059]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:26979516|PMID:15590823]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:19940160|PMID:16581788]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:16581788]" /experiment="EXISTENCE:mutant phenotype:GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:21183953]" /experiment="EXISTENCE:mutant phenotype:GO:0031669 cellular response to nutrient levels [PMID:21183953]" /experiment="EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:15121833]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:21148207]" /experiment="EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:1425591]" /experiment="EXISTENCE:mutant phenotype:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:6351059]" /experiment="EXISTENCE:mutant phenotype:GO:1990139 protein localization to nuclear periphery [PMID:31211995]" /experiment="EXISTENCE:physical interaction:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:19940160]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20308326|PMID:21183953]" /note="bZIP transcriptional activator of amino acid biosynthetic genes; activator responds to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels; contains four upstream open reading frames (uORFs) in 5' untranslated region which regulate translation; participates in sulfur starvation-induced autophagy along with Met4p, but is dispensable" /db_xref="GeneID:856709" /db_xref="SGD:S000000735" ORIGIN 1 mseyqpslfa lnpmgfspld gskstnenvs aststakpmv gqlifdkfik teedpiikqd 61 tpsnldfdfa lpqtatapda ktvlpipeld davvesffss stdstpmfey enlednskew 121 tslfdndipv ttddvsladk aiesteevsl vpsnlevstt sflptpvled akltqtrkvk 181 kpnsvvkksh hvgkddesrl dhlgvvaynr kqrsiplspi vpessdpaal krarnteaar 241 rsrarklqrm kqledkveel lsknyhlene varlkklvge r // LOCUS NP_001335767 126 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YEL008W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335767 VERSION NP_001335767.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348823.1 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80287. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..126 /product="uncharacterized protein" /calculated_mol_wt="13891" CDS 1..126 /locus_tag="YEL008W" /coded_by="NM_001348823.1:1..381" /note="hypothetical protein; conserved among S. cerevisiae strains; YEL008W is not an essential gene; predicted to be involved in metabolism" /db_xref="GeneID:856710" /db_xref="SGD:S000000734" ORIGIN 1 mlmhfiprrs skavqfnwle igvwrggvyv kkgivnartn nsnfykmpvv fgivkgmgal 61 cvhawgmgyg giidcspvte hgnisvlqle ympwiclski mscsvasrhs nvwimdetia 121 plvgcl // LOCUS NP_010909 666 aa linear PLN 30-JUN-2025 DEFINITION Mit1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010909 VERSION NP_010909.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178822.1 REFERENCE 1 (residues 1 to 666) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 666) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 666) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 666) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07644. Method: conceptual translation. FEATURES Location/Qualifiers source 1..666 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..666 /product="Mit1p" /calculated_mol_wt="72403" Region 1..284 /region_name="TOS9" /note="Gluconate transport-inducing protein [Signal transduction mechanisms / Carbohydrate transport and metabolism]; COG5037" /db_xref="CDD:227370" CDS 1..666 /gene="MIT1" /locus_tag="YEL007W" /coded_by="NM_001178822.1:1..2001" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1" /db_xref="GeneID:856711" /db_xref="SGD:S000000733" ORIGIN 1 mdieptfkgy iededdalli lqatldgklk hiprrpyeie rpylivsgsi fvfieeisgi 61 krwtdgvsws psrisgkfli ykeldkenag snanatssgs tdsavitdgt sgarnnpsss 121 kiklpplknh qfdlpptmgh ssfeseqdts ispsnrsnlp lkytglvkkt isvklkrppf 181 nsienlhivs yysvkdikqn clvtpkaspf lkdvrpsqel ivamgnttlg nvknnstttg 241 ngpnninnks nsstplntvi stnnnsanin aagsnqftsa nknyyyknde ssgypitqfa 301 palpsttlmy tanppyitqs pdntnatgmn thvnnnnnns nnssnsnnsn nnnnnnnnnn 361 nnnnnninni nnvntnagng nnpnrfhnas faynttgdfi npqqqgqisy pfyyttipin 421 npnyyttqpp npvtnastne nqgystsstq hpyyghptes qsasaaagat gtpgtaenvl 481 pvssmqpllh qannnsassa tstapypvys mnvnvpyyns sasaykraqe nttsntnaep 541 sgatstnsgt mlsnpayans qytpsqvyyq gfpqyamasa qnpsmyqhqh qhplptvypi 601 atpqqnimss ghtlstigsd pqhhhyqqep ndhknfamgh annnilnitn ndtmnnlntn 661 tstttq // LOCUS NP_010910 335 aa linear PLN 30-JUN-2025 DEFINITION NAD+ transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_010910 VERSION NP_010910.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178821.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07645. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..335 /product="NAD+ transporter" /calculated_mol_wt="36830" Region 43..128 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 135..227 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 240..334 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..335 /gene="YEA6" /locus_tag="YEL006W" /gene_synonym="NDT2" /coded_by="NM_001178821.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0035352 NAD transmembrane transport [PMID:16291748]" /experiment="EXISTENCE:genetic interaction:GO:0051724 NAD transmembrane transporter activity [PMID:16291748]" /experiment="EXISTENCE:mutant phenotype:GO:0035352 NAD transmembrane transport [PMID:16291748]" /experiment="EXISTENCE:mutant phenotype:GO:0051724 NAD transmembrane transporter activity [PMID:16291748]" /note="Mitochondrial NAD+ transporter; member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog; YEA6 has a paralog, YIA6, that arose from the whole genome duplication; human NAD+ transporter MCART1/SLC25A51 functionally complements the yia6 yea6 double null mutant, and yeast YEA6 reciprocally complements defects in MCART1/SLC25A51 null cells" /db_xref="GeneID:856712" /db_xref="SGD:S000000732" ORIGIN 1 mnngdnkttl ensknaslan gnyaiptkln rlkknadprv aaisgalsga lsamlvcpfd 61 vaktrlqaqg lqnmthqsqh ykgffgtfat ifkdegaagl ykglqptvlg yiptlmiyfs 121 vydfcrkysv difphspfls nassaitaga istvatnpiw vvktrlmlqt gigkysthyk 181 gtidtfrkii qqegakalya glvpallgml nvaiqfplye nlkirfgyse stdvstdvts 241 snfqklilas mlskmvastv typheilrtr mqlksdlpnt vqrhllplik ityrqegfag 301 fysgfatnlv rtvpaavvtl vsfeyskkyl ttffq // LOCUS NP_010911 282 aa linear PLN 30-JUN-2025 DEFINITION Vab2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010911 VERSION NP_010911.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178820.3 REFERENCE 1 (residues 1 to 282) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 282) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 282) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 282) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07646. On Jul 30, 2012 this sequence version replaced NP_010911.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..282 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..282 /product="Vab2p" /calculated_mol_wt="31234" CDS 1..282 /gene="VAB2" /locus_tag="YEL005C" /gene_synonym="VAB31" /coded_by="NM_001178820.3:1..849" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]" /note="Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Vps21p-GFP; has potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of; Vab2p-GFP-fusion localizes to cytoplasm in punctate pattern" /db_xref="GeneID:856713" /db_xref="SGD:S000000731" ORIGIN 1 mvadltkgil kwksriefda vgsssyyeel kglpplashk kltqaaifns tkyellqvkk 61 dilsiyevvs rdideernqm qqielqlkks lkkvehsykn vlkqrastnc ingndrllan 121 aekkigslne elacvndivs divnnltaln anlpkkaqll kddsinvahy pllfdflhks 181 cpksiiatse asihenasps pllehdelpa esinsfygen elqsdslapl qthddnissc 241 kkilppkfnt tsgpsietnf enisadglty tkcslknsis lt // LOCUS NP_010912 342 aa linear PLN 30-JUN-2025 DEFINITION Yea4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010912 VERSION NP_010912.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178819.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07647. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..342 /product="Yea4p" /calculated_mol_wt="39135" Region 3..327 /region_name="UAA" /note="UAA transporter family; pfam08449" /db_xref="CDD:462479" CDS 1..342 /gene="YEA4" /locus_tag="YEL004W" /coded_by="NM_001178819.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10788474]" /experiment="EXISTENCE:genetic interaction:GO:0015786 UDP-glucose transmembrane transport [PMID:18693752]" /experiment="EXISTENCE:mutant phenotype:GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity [PMID:10788474]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:10788474]" /experiment="EXISTENCE:mutant phenotype:GO:0015786 UDP-glucose transmembrane transport [PMID:18693752]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:10788474]" /experiment="EXISTENCE:mutant phenotype:GO:1990569 UDP-N-acetylglucosamine transmembrane transport [PMID:10788474]" /note="Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter; required for cell wall chitin synthesis; localized to the ER" /db_xref="GeneID:856714" /db_xref="SGD:S000000730" ORIGIN 1 mwnslkafal vfggccsnvi tfetlmsnet gsinnlitfc qflfvtcqgl pefldvhqpf 61 pyfkplktpl hvyvitvvlf yissttnnnv fkynisipih ivfrcfgtvi tmftcwllng 121 rkytkiqils tlfltigaii aslfkdadfr yqdlklqawk igsdqsvdlt fifgicilvl 181 ssftssllsa ynertyqkyg khwkenifys hflslplflf srkqliheyr vmrkserilc 241 snfggkilvp reetlllfnv ltqyfcvkgv nilasktnal tlsitllvrk fislllsvrl 301 fdnnlsytgy igvylvffga fiyslgsihp rqndkgaikk sk // LOCUS NP_010913 111 aa linear PLN 30-JUN-2025 DEFINITION tubulin-binding prefolding complex subunit GIM4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010913 VERSION NP_010913.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178818.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07648. On Jul 30, 2007 this sequence version replaced NP_010913.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..111 /product="tubulin-binding prefolding complex subunit GIM4" /calculated_mol_wt="12863" Region 9..106 /region_name="Prefoldin_2" /note="prefoldin subunit 2; cd23163" /db_xref="CDD:467479" Region 9..46 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467479" Site order(12,15..16,19..20,22..23,26..27,30,84,87,91,95,98..99, 102..103,106) /site_type="other" /note="prefoldin beta subunit /TRiC interface [polypeptide binding]" /db_xref="CDD:467479" Site order(39,42,46..47,50..56,58..63,67..68,72) /site_type="other" /note="prefoldin oligomer interface [polypeptide binding]" /db_xref="CDD:467479" Region 66..106 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467479" CDS 1..111 /gene="GIM4" /locus_tag="YEL003W" /gene_synonym="PFD2" /coded_by="NM_001178818.1:1..336" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9463374]" /experiment="EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:9463374]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9463374]" /experiment="EXISTENCE:physical interaction:GO:0016272 prefoldin complex [PMID:9463374]" /note="Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it" /db_xref="GeneID:856715" /db_xref="SGD:S000000729" ORIGIN 1 meqrnnvfqa kyneykqile elqtkiielg hdkdehtivi ktlkdaeptr kcyrmiggal 61 vesdvqtslp iletkkenie gtiskmketl iqtakefekw kkdnkiqvvk n // LOCUS NP_010914 430 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-diphosphooligosaccharide-protein glycotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010914 VERSION NP_010914.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178817.3 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07649. On Jul 30, 2012 this sequence version replaced NP_010914.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..430 /product="dolichyl-diphosphooligosaccharide-protein glycotransferase" /calculated_mol_wt="49261" Region 25..417 /region_name="DDOST_48kD" /note="Oligosaccharyltransferase 48 kDa subunit beta; pfam03345" /db_xref="CDD:460890" CDS 1..430 /gene="WBP1" /locus_tag="YEL002C" /coded_by="NM_001178817.3:1..1293" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:1724755]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12860997|PMID:1724755]" /experiment="EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]" /experiment="EXISTENCE:direct assay:GO:0016757 glycosyltransferase activity [PMID:1600939]" /experiment="EXISTENCE:mutant phenotype:GO:0004576 oligosaccharyl transferase activity [PMID:1600939]" /experiment="EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:12974639]" /experiment="EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]" /experiment="EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]" /note="Non-catalytic beta subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes N-linked glycosylation of newly synthesized proteins in the ER; forms a pocket with Ost2p involved in binding terminal glucose units of the donor glycan; human homolog DDOST can complement yeast growth defect during down-regulation of the yeast gene" /db_xref="GeneID:856716" /db_xref="SGD:S000000728" ORIGIN 1 mrtdwnfffc illqaifvvg tqtsrtlvly dqstepleey svylkdleqr nykleyldin 61 ststtvdlyd keqrlfdnii vfptkggknl arqipvkqli kffenegnil cmsspgavpn 121 tirlflnelg iypspkghvi rdyfspssee lvvssnhlln kyvynarkse dfvfgessaa 181 llenreqivp ilnaprtsft eskgkcnswt sgsqgflvvg fqnlnnarlv wigssdflkn 241 knqdsnqefa kellkwtfne ksviksvhav hshadgtsyd eepykikdkv iysvgfsewn 301 geewlphiad diqfelrqvd pyyrltlsps gndsetqyyt tgefilpdrh gvftfltdyr 361 kiglsfttdk dvkairhlan deyprsweis nswvyisaic gvivawiffv vsfvttssvg 421 kkletfkktn // LOCUS NP_010915 225 aa linear PLN 30-JUN-2025 DEFINITION Irc22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010915 VERSION NP_010915.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178816.1 REFERENCE 1 (residues 1 to 225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 225) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07650. Method: conceptual translation. FEATURES Location/Qualifiers source 1..225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..225 /product="Irc22p" /calculated_mol_wt="24861" CDS 1..225 /gene="IRC22" /locus_tag="YEL001C" /coded_by="NM_001178816.1:1..678" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762|PMID:22842922]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci" /db_xref="GeneID:856717" /db_xref="SGD:S000000727" ORIGIN 1 mrfsmligfn lltalssfca aisannsdnv eheqevaeav appsinievk ydvvgkesen 61 hdsflefyae dtatlaynvt nwedtnitif gvngtivtyp hgypvaditg asigpyemev 121 ngtskfgqdv tlnlpegqyf lipfllasrf deivriaapp tlfeivsppi sffnpqflsv 181 qviflaiigg vsyyymkskt nqrpskksat vkkvdeswlp etykk // LOCUS NP_010916 762 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,3-mannosyltransferase MNN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010916 VERSION NP_010916.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178892.1 REFERENCE 1 (residues 1 to 762) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 762) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 762) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 762) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07651. Method: conceptual translation. FEATURES Location/Qualifiers source 1..762 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..762 /product="alpha-1,3-mannosyltransferase MNN1" /calculated_mol_wt="88399" Region 317..613 /region_name="Mannosyl_trans3" /note="Mannosyltransferase putative; pfam11051" /db_xref="CDD:402574" CDS 1..762 /gene="MNN1" /locus_tag="YER001W" /coded_by="NM_001178892.1:1..2289" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:7962051]" /experiment="EXISTENCE:direct assay:GO:0006493 protein O-linked glycosylation [PMID:7962051]" /experiment="EXISTENCE:mutant phenotype:GO:0000033 alpha-1,3-mannosyltransferase activity [PMID:8146181]" /experiment="EXISTENCE:mutant phenotype:GO:0006491 N-glycan processing [PMID:8146181]" /note="Alpha-1,3-mannosyltransferase; integral membrane glycoprotein of Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides; one of five S. cerevisiae proteins of MNN1 family; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:856718" /db_xref="SGD:S000000803" ORIGIN 1 mlalrrfiln qrslrsctip ilvgaliiil vlfqlvthrn dalirssnvn stnkktlkda 61 dpkvlieafg spevdpvdti pvsplelvpf ydqsidtkrs sswlinkkgy ykhfnelslt 121 drckfyfrtl ytlddewtns vkkleysind negvdegkda ngnpmdekse rlyrrkydmf 181 qaferirayd rcfmqanpvn iqeifpksdk mskervqskl iktlnatfpn ydpdnfkkyd 241 qfefehkmfp finnfttetf hemvpkitsp fgkvleqgfl pkfdhktgkv qeyfkyeydp 301 sktfwanwrd msakvagrgi vlslgsnqfp lavkfiaslr fegntlpiqv vyrgdelsqe 361 lvdkliyaar spdfkpvenn ydnstnvpqe iwfldvsnti hpkwrgdfgs ykskwlvvll 421 nllqefvfld idaisyekid nyfktteyqk tgtvfyrera lrenvnerci aryetllprn 481 lesknfqnsl lidpdhalne cdntltteey ifkaffhhrr qhqleaglfa vdkskhtipl 541 vlaamihlak ntahcthgdk enfwlgflaa ghtyalqgvy sgaigdyvkk tdlngkrqea 601 aveicsgqia hmstdkktll wvngggtfck hdnaakddwk kdgdfkkfkd qfktfeemek 661 yyyitpissk yvilpdpksd dwhrasagac ggyiwcathk tllkpysynh rtthgelitl 721 deeqrlhida vntvwshank dntrsfteee ikelensrhe qs // LOCUS NP_010917 231 aa linear PLN 30-JUN-2025 DEFINITION Nop16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010917 VERSION NP_010917.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178893.3 REFERENCE 1 (residues 1 to 231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 231) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07652. On Jul 30, 2012 this sequence version replaced NP_010917.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..231 /product="Nop16p" /calculated_mol_wt="26770" Region 5..222 /region_name="Nop16" /note="Ribosome biogenesis protein Nop16; pfam09420" /db_xref="CDD:430599" CDS 1..231 /gene="NOP16" /locus_tag="YER002W" /coded_by="NM_001178893.3:1..696" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]" /note="Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis" /db_xref="GeneID:856719" /db_xref="SGD:S000000804" ORIGIN 1 mtsvrkrkmn rssvgkatrr nkdkqrkini qsnpiiaanw dysltmaqny kklglraklq 61 tpaggkeadl skvvkriplt kpvldedede degedeqndy naatvelden eipeggariq 121 rdkngdvvrv vygkkknfda dedvneikar dtteetevvk kleelasrpv irkersqser 181 eeewleklyk khgddykkmf fdkklniyqq segdlkrrll rwkkrngias k // LOCUS NP_010918 429 aa linear PLN 30-JUN-2025 DEFINITION mannose-6-phosphate isomerase PMI40 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010918 VERSION NP_010918.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178894.1 REFERENCE 1 (residues 1 to 429) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 429) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 429) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 429) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07653. Method: conceptual translation. FEATURES Location/Qualifiers source 1..429 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..429 /product="mannose-6-phosphate isomerase PMI40" /EC_number="5.3.1.8" /calculated_mol_wt="48058" Region 7..407 /region_name="cupin_RmlC-like" /note="RmlC-like cupin superfamily; cl40423" /db_xref="CDD:477354" Site order(17,47,49,98,106..107,109,111,134,136,138,281,283,290, 292,296,300) /site_type="active" /db_xref="CDD:380414" CDS 1..429 /gene="PMI40" /locus_tag="YER003C" /coded_by="NM_001178894.1:1..1290" /experiment="EXISTENCE:direct assay:GO:0004476 mannose-6-phosphate isomerase activity [PMID:8011630]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:1377774]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:1377774]" /experiment="EXISTENCE:mutant phenotype:GO:0009298 GDP-mannose biosynthetic process [PMID:1377774]" /note="Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation" /db_xref="GeneID:856720" /db_xref="SGD:S000000805" ORIGIN 1 msnklfrlda gyqqydwgki gsssavaqfa ahsdpsvqie qdkpyaelwm gthskmpsyn 61 heskeslrdi isknpsamlg kdiidkfhat nelpflfkvl siekvlsiqa hpdkalgkil 121 haqdpknypd dnhkpemaia vtdfegfcgf kplqeiadel kripelrniv geetsrnfie 181 niqpsaqkgs pedeqnkkll qavfsrvmna sddkikiqar slversknsp sdfnkpdlpe 241 liqrlnkqfp ddvglfcgcl llnhcrlnag eaiflrakdp hayisgdime cmaasdnvvr 301 agftpkfkdv knlvsmltyt ydpvekqkmq plkfdrssgn gksvlynppi eefavlettf 361 deklgqrhfe gvdgpsilit tkgngyikad gqklkaepgf vffiaphlpv dleaedeaft 421 tyrafvepn // LOCUS NP_010919 231 aa linear PLN 30-JUN-2025 DEFINITION Fmp52p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010919 VERSION NP_010919.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178895.1 REFERENCE 1 (residues 1 to 231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 231) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07654. Method: conceptual translation. FEATURES Location/Qualifiers source 1..231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..231 /product="Fmp52p" /calculated_mol_wt="24955" Region 1..220 /region_name="CC3_like_SDR_a" /note="CC3(TIP30)-like, atypical (a) SDRs; cd05250" /db_xref="CDD:187560" Site order(7,9..12,34..35,52,72..75,89,93,112..114,125,129, 149..152) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:187560" Site order(90,114,125,129) /site_type="active" /db_xref="CDD:187560" CDS 1..231 /gene="FMP52" /locus_tag="YER004W" /coded_by="NM_001178895.1:1..696" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="hypothetical protein; localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation" /db_xref="GeneID:856721" /db_xref="SGD:S000000806" ORIGIN 1 mnglvlgatg lcgggflrha qeapqfskvy ailrrelpfp atdkvvaive rdnskwsqli 61 tnemnpqvlf talattraaa ggldkqykid hdlnlqlaqa akekgcetiv lvssagahpd 121 srfgymkmkg eierdviald fkhiiilrpg pllgertnsk qsgfggnlta algtrvyrsr 181 fqrllgypvy gdevgkvgvh lalntsgkdk vqfvsskdil disaslekia t // LOCUS NP_010920 630 aa linear PLN 30-JUN-2025 DEFINITION apyrase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010920 VERSION NP_010920.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178896.3 REFERENCE 1 (residues 1 to 630) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 630) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 630) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 630) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07655. On Jul 30, 2012 this sequence version replaced NP_010920.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..630 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..630 /product="apyrase" /EC_number="3.6.1.5" /calculated_mol_wt="71721" Region 1..455 /region_name="GDA1_CD39" /note="GDA1/CD39 (nucleoside phosphatase) family; pfam01150" /db_xref="CDD:426082" CDS 1..630 /gene="YND1" /locus_tag="YER005W" /gene_synonym="APY1; YEJ5" /coded_by="NM_001178896.3:1..1893" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:10551827]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0017110 nucleoside diphosphate phosphatase activity [PMID:10409709]" /experiment="EXISTENCE:direct assay:GO:0017111 ribonucleoside triphosphate phosphatase activity [PMID:10409709]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:10409709]" /note="Apyrase with wide substrate specificity; helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity" /db_xref="GeneID:856722" /db_xref="SGD:S000000807" ORIGIN 1 mlientndrf gividagssg srihvfkwqd tesllhatnq dsqsilqsvp hihqekdwtf 61 klnpglssfe kkpqdayksh ikplldfakn iipeshwssc pvfiqatagm rllpqdiqss 121 ildglcqglk hpaeflvedc saqiqvidge teglygwlgl nylyghfndy npevsdhftf 181 gfmdmggast qiafaphdsg eiarhrddia tiflrsvngd lqkwdvfvst wlgfganqar 241 rrylaqlint lpentndyen ddfstrnlnd pcmprgsstd fefkdtifhi agsgnyeqct 301 ksiyplllkn mpcddepclf ngvhapridf andkfigtse ywytandvfk lggeynfdkf 361 skslrefcns nwtqilansd kgvynsipen flkdacfkgn wvlnilhegf dmpridvdae 421 nvndrplfqs vekveerels wtlgrillya sgsilagndd fmvgiapser rtkltgkkfi 481 pgkllesdql rkqssslsnk gflmwfaiic cifylifhrs hiirrrfsgl ynitkdfktg 541 irrrlkflrr sdpfsrleeg elgtdvdgfk dvyrmksssm fdlgkssatm qrehepqrta 601 sqsanlapsn lrpafsmadf skfkdsrlyd // LOCUS NP_010921 520 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding GTPase NUG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010921 VERSION NP_010921.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178897.1 REFERENCE 1 (residues 1 to 520) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 520) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 520) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 520) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07656. Method: conceptual translation. FEATURES Location/Qualifiers source 1..520 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..520 /product="RNA-binding GTPase NUG1" /calculated_mol_wt="57578" Region 13..89 /region_name="GN3L_Grn1" /note="GNL3L/Grn1 putative GTPase; pfam08701" /db_xref="CDD:462569" Region <138..214 /region_name="MMR_HSR1" /note="50S ribosome-binding GTPase; pfam01926" /db_xref="CDD:460387" Region 177..340 /region_name="Nucleostemin_like" /note="A circularly permuted subfamily of the Ras GTPases; cd04178" /db_xref="CDD:206753" Site order(213..214,216..217,242..244,289..295,339) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206753" Site 213..216 /site_type="other" /note="G4 box" /db_xref="CDD:206753" Site 242..244 /site_type="other" /note="G5 box" /db_xref="CDD:206753" Site 287..294 /site_type="other" /note="G1 box" /db_xref="CDD:206753" Site 317..324 /site_type="other" /note="Switch I region" /db_xref="CDD:206753" Site 320 /site_type="other" /note="G2 box" /db_xref="CDD:206753" Site 336..339 /site_type="other" /note="G3 box" /db_xref="CDD:206753" Site 338..340 /site_type="other" /note="Switch II region" /db_xref="CDD:206753" CDS 1..520 /gene="NUG1" /locus_tag="YER006W" /coded_by="NM_001178897.1:1..1563" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:16803892]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16803892]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247|PMID:16803892]" /experiment="EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:11583615]" /experiment="EXISTENCE:genetic interaction:GO:0030687 preribosome, large subunit precursor [PMID:16803892]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11583615]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12089522]" /note="GTPase that associates with nuclear 60S pre-ribosomes; required for export of 60S ribosomal subunits from the nucleus" /db_xref="GeneID:856723" /db_xref="SGD:S000000808" ORIGIN 1 mrvrkrqsrr tstklkegik kkasahrkke kkmakkdvtw rsrskkdpgi psnfpykaki 61 leeieakkmk dleerelakq qrlearkaak eqgvdamded mieddengla alvesaqqaa 121 aeyegtpsnd advrddeldv idynidfyge dvegeselek srkaydkifk svidasdvil 181 yvldardpes trsrkveeav lqsqgkrlil ilnkvdlipp hvleqwlnyl kssfptiplr 241 assgavngts fnrklsqttt asalleslkt ysnnsnlkrs ivvgvigypn vgkssvinal 301 larrggqska cpvgneagvt tslreikidn klkildspgi cfpsenkkrs kveheaelal 361 lnalpakhiv dpypavlmlv krlaksdemt esfkklyeip pipandadtf tkhflihvar 421 krgrlgkggi pnlasaglsv lndwrdgkil gwvlpntsaa asqqdkqnls tintgtkqap 481 iaanestivs ewskefdldg lfssldkaid askdqdtmme // LOCUS NP_010922 518 aa linear PLN 30-JUN-2025 DEFINITION Pac2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010922 VERSION NP_010922.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178898.1 REFERENCE 1 (residues 1 to 518) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 518) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 518) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 518) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07657. Method: conceptual translation. FEATURES Location/Qualifiers source 1..518 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..518 /product="Pac2p" /calculated_mol_wt="59127" Region 5..72 /region_name="CAP_GLY" /note="Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; smart01052" /db_xref="CDD:214997" Region 45..>333 /region_name="LRR" /note="Leucine-rich repeat (LRR) protein [Transcription]; COG4886" /db_xref="CDD:443914" Region 154..179 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 180..204 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 205..229 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 256..277 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 278..298 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 299..324 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region <445..502 /region_name="Ubl1_cv_Nsp3_N-like" /note="first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; cl28922" /db_xref="CDD:475130" CDS 1..518 /gene="PAC2" /locus_tag="YER007W" /coded_by="NM_001178898.1:1..1557" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:9215891]" /experiment="EXISTENCE:genetic interaction:GO:0007021 tubulin complex assembly [PMID:9215891]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9215891]" /experiment="EXISTENCE:physical interaction:GO:0043014 alpha-tubulin binding [PMID:9885248]" /note="Microtubule effector required for tubulin heterodimer formation; binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl" /db_xref="GeneID:856724" /db_xref="SGD:S000000809" ORIGIN 1 mtyeigdrlk iggyfctikf igvikpwpsv kaygvewddh srgkhsgtid dihyfdvqip 61 nsgsflkesk ikspgvrrit fyealsekyg gssnnindls ignkrveglg fdelnarnkn 121 ykklrkialr dsdvailfqn qdelnrviqn cvnvkdldls lnlftninsl cefieplknl 181 eslnisqnkl lsgwdnlkey dlshiktlrl sscglsykhi gkllksfrtl kmldlsynnl 241 tsagiqnfen eipctleeln isgnnlisfp lfpknltlkg lnvsnnqisr apsiaiysve 301 slditdnkfk ersliddlnk tfpslknihl sgnefnyngn yinveeqatf yevlarfdrv 361 mvlngsicdv ktrreaemff vskvmnnels ydtnlprwss liksyeidms klsfnneret 421 rqslvlkiki ragkkpssdl dywvlpsftv ryvksvicrk lnfdilnvkl fhensegmin 481 eikynfrpis dfnvvngdii hvsspvnnks iqkvnsps // LOCUS NP_010923 181 aa linear PLN 30-JUN-2025 DEFINITION translation machinery-associated protein 20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010923 VERSION NP_010923.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180857.3 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07658. On Jul 30, 2012 this sequence version replaced NP_010923.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..181 /product="translation machinery-associated protein 20" /calculated_mol_wt="20147" Region 3..78 /region_name="MCT1_N" /note="N-terminal domain of multiple copies T cell malignancies 1 and related proteins; cd11609" /db_xref="CDD:211422" Site order(31..32,70,72,76..78) /site_type="other" /note="PUA domain interface [polypeptide binding]" /db_xref="CDD:211422" Region 78..176 /region_name="PUA_MCTS-1-like" /note="PUA RNA-binding domain of malignant T cell-amplified sequence 1 and related proteins; cd21155" /db_xref="CDD:409297" Site order(96,102,104..106,108..110,162..163,167..170) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:409297" CDS 1..181 /gene="TMA20" /locus_tag="YER007C-A" /coded_by="NM_001180857.3:1..546" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:23613772]" /experiment="EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:38198768]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:16702403]" /note="Ribosome-associated protein; involved along with heterodimeric partner Tma22p in recycling of 40S ribosomal subunits; involved in nonsense-mediated mRNA decay (NMD); contains a putative RNA binding domain; null mutant exhibits translation defects; localizes to the cytosol; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856725" /db_xref="SGD:S000002957" ORIGIN 1 mfkkftredv hsrskvkssi qrtlkaklvk qypkiedvid elipkksqie likcedkiql 61 ysvdgevlff qkfdelipsl klvhkfpeay ptvqvdrgai kfvlsganim cpgltsagad 121 lppapgyekg tivvinaenk enalaigelm mgteeiksvn kghsielihh lgdplwnfsv 181 e // LOCUS NP_010924 1336 aa linear PLN 30-JUN-2025 DEFINITION GTP-Rho binding exocyst subunit SEC3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010924 VERSION NP_010924.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178899.1 REFERENCE 1 (residues 1 to 1336) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1336) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1336) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1336) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07659. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1336 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1336 /product="GTP-Rho binding exocyst subunit SEC3" /calculated_mol_wt="154564" Region 82..232 /region_name="PH_Sec3" /note="Sec 3 Pleckstrin homology-like domain; cd13315" /db_xref="CDD:270125" Site order(84,134,136,184,199..201) /site_type="other" /note="Rho1 binding site [polypeptide binding]" /db_xref="CDD:270125" Site order(109,168,177..180,208,211,214..219,221,223..224, 226..232) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:270125" Site order(135,137,155,157,168,194,196) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:270125" Region 348..>593 /region_name="TolA" /note="Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; COG3064" /db_xref="CDD:442298" Region 348..>445 /region_name="MAP7" /note="MAP7 (E-MAP-115) family; pfam05672" /db_xref="CDD:461709" Region 640..1316 /region_name="Sec3_C" /note="Exocyst complex component Sec3; cl19950" /db_xref="CDD:418729" CDS 1..1336 /gene="SEC3" /locus_tag="YER008C" /gene_synonym="PSL1" /coded_by="NM_001178899.1:1..4011" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9491896|PMID:11595741]" /experiment="EXISTENCE:direct assay:GO:0000145 exocyst [PMID:8978675]" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:18195105]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11595741|PMID:22842922|PMID:17717527|PMID:9491896]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9491896|PMID:22842922|PMID:26928762|PMID:11595741]" /experiment="EXISTENCE:direct assay:GO:0006887 exocytosis [PMID:15772160]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:11283608]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9491896|PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:12913108|PMID:17717527]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:genetic interaction:GO:0048309 endoplasmic reticulum inheritance [PMID:15583030]" /experiment="EXISTENCE:genetic interaction:GO:0051601 exocyst localization [PMID:18946089|PMID:17717527]" /experiment="EXISTENCE:mutant phenotype:GO:0001927 exocyst assembly [PMID:15583030]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:6996832]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:15583030|PMID:12960429]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:11595741]" /note="Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in a Rho1p-dependent, actin-independent manner, targeting and anchoring the exocyst to the plasma membrane with Exo70p; direct GTP Rho1p effector; required for ER inheritance; relocalizes away from bud neck upon DNA replication stress" /db_xref="GeneID:856726" /db_xref="SGD:S000000810" ORIGIN 1 mrsskspfkr kshsretshd entsffhkrt isgssahhsr nvsqgavpss appvsggnys 61 hkrnvsrasn ssqtsnflae qyerdrkaii nccfsrpdhk tgeppnnyit hvriiedskf 121 pssrpppdsk lenkkkrlli lsakpnnakl iqihkarens dgsfqigrtw qltelvrvek 181 dleisegfil tmskkyywet nsakertvfi kslitlyiqt feghvpelvn wdlslfylde 241 rsyqravitn rpgsvspiks ptsnfttntt qsvgsvpfsa ptertrrset esvnpvstpa 301 sveyhagmks lnkapyssns tlnevnkrye leqqqqqeea elrrleeqkr lqlqkenemk 361 rleeerrikq eerkrqmele hqrqleeeer krqmeleakk qmelkrqrqf eeeqrlkker 421 elleiqrkqr eqetaerlkk eeqealakke eeekskrnkv dnesytqein gkvdnlledl 481 navlaeetet tptmqngtyv perstarahd qlkkplniak veslggsdln dsislsdeia 541 glntsnlsge dqdekndlsf ekgdevrysn nfegeaphvy hevsiiqeea pavsqklilp 601 eenneseali eskeeiktme niddevllei ltdinwsied dadsmierid lrlaeteylf 661 nqnllslqki gpnirpyedk vndechriip tlslflmems nfsndienve sqdnglqves 721 ankkllwntl dellktvsld eislnqllec pireknlpwm enqlnlllka fqaigsdgne 781 veynlreisg lkqrlqfyek vtkiflnriv eemqkkfsni rgqdishdqm irilttllif 841 splilfckei sqksyqaive nwnvsiqpvy melwtkkisq lqgidtndek mnelslsqll 901 newdtfrker ktndinpvfk nsfslltecl qtmrqecivy qnfvevffhi sskhnfeeyi 961 khfndpdapp illdtvkvmq sdreaaviet qlvsrifqpi vtrlssyfve lvkaeptvap 1021 altfylenei kslessnhef llsavtrmyt qikqvwsdnv eeqvlhferi snattngeil 1081 pgildlpvgl knsedlfqfa krsmdikdtd egyesielmn ssfrklsiaa trsithkevn 1141 ssinpnlsdt aalnndymet isllvnsnwl temlsmlnfn kdgifdtslq nvkkvfdvek 1201 esyasfllrd tmpkltafvy gvsniientn nvnmtnpsrw aaysrqnlen illaytshei 1261 etlvkrlhth mvndfgyhqe nainnvlcdk lwsciqgqtv slylklytvi dkhyrgtnir 1321 ftkndiisaf eeykna // LOCUS NP_010925 125 aa linear PLN 30-JUN-2025 DEFINITION Ran GTPase-binding protein NTF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010925 VERSION NP_010925.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178900.1 REFERENCE 1 (residues 1 to 125) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 125) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 125) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 125) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07660. Method: conceptual translation. FEATURES Location/Qualifiers source 1..125 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..125 /product="Ran GTPase-binding protein NTF2" /calculated_mol_wt="14322" Region 4..123 /region_name="NTF2" /note="Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many...; cd00780" /db_xref="CDD:238403" Site order(32,38,45,70,72..73,83,106,116..118,120,122) /site_type="active" /note="TAP/p15 interaction [active]" /db_xref="CDD:238403" Site order(36,38..39,67..68,70,72..73,81,85..87,91,94..97,100, 106,116..118,120..123) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238403" Site order(39..40,57,62,86,88,90..91,94,97,119,121,123) /site_type="active" /note="RanGDP-NTF2 interaction [active]" /db_xref="CDD:238403" CDS 1..125 /gene="NTF2" /locus_tag="YER009W" /coded_by="NM_001178900.1:1..378" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:8702493]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:10889207]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:11024003|PMID:8702493]" /experiment="EXISTENCE:mutant phenotype:GO:0006913 nucleocytoplasmic transport [PMID:8702493]" /note="Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport" /db_xref="GeneID:856727" /db_xref="SGD:S000000811" ORIGIN 1 msldfntlaq nftqfyynqf dtdrsqlgnl yrnesmltfe tsqlqgakdi veklvslpfq 61 kvqhrittld aqpaspngdv lvmitgdlli deeqnpqrfs qvfhlipdgn syyvfndifr 121 lnysa // LOCUS NP_010926 234 aa linear PLN 30-JUN-2025 DEFINITION bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010926 VERSION NP_010926.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178901.3 REFERENCE 1 (residues 1 to 234) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 234) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 234) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 234) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07661. On Jul 30, 2012 this sequence version replaced NP_010926.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..234 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..234 /product="bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase" /EC_number="4.1.1.112" /EC_number="4.1.3.17" /calculated_mol_wt="25432" Region 13..185 /region_name="RraA_family" /note="ribonuclease activity regulator RraA family; cd16841" /db_xref="CDD:319245" Site order(13,16..17,25,122..125,139..142,179..181,183) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:319245" CDS 1..234 /locus_tag="YER010C" /coded_by="NM_001178901.3:1..705" /experiment="EXISTENCE:direct assay:GO:0008948 oxaloacetate decarboxylase activity [PMID:24359411]" /experiment="EXISTENCE:direct assay:GO:0019619 3,4-dihydroxybenzoate catabolic process [PMID:24359411]" /experiment="EXISTENCE:direct assay:GO:0047443 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity [PMID:24359411]" /note="Bifunctional HMG aldolase/oxaloacetate decarboxylase; requires divalent metal ions for activity; competitively inhibited by oxalate; forms a ring-shaped homotrimer; similar to members of the prokaryotic RraA family of class II (divalent metal ion dependent) pyruvate aldolases from the meta cleavage pathways of protocatechuate and gallate" /db_xref="GeneID:856728" /db_xref="SGD:S000000812" ORIGIN 1 msdlqklqrf stcdisdgll nvyniptggy fpnltaispp qnssivgtay tvlfapiddp 61 rpavnyidsv ppnsilvlal ephlqsqfhp fikitqamyg glmstraqyl ksngtvvfgr 121 irdvdehrtl nhpvfaygvg scapkavvka vgtnvqlkil tsdgvtqtic pgdyiagdnn 181 givripvqet disklvtyie ksievdllvs edikngipak qaqndrrsvl kkyi // LOCUS NP_010927 254 aa linear PLN 30-JUN-2025 DEFINITION GPI-anchored mannoprotein [Saccharomyces cerevisiae S288C]. ACCESSION NP_010927 VERSION NP_010927.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178902.1 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07662. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..254 /product="GPI-anchored mannoprotein" /calculated_mol_wt="24775" Region 19..112 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..254 /gene="TIR1" /locus_tag="YER011W" /gene_synonym="SRP1" /coded_by="NM_001178902.1:1..765" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:9363789]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460|PMID:8733242]" /experiment="EXISTENCE:direct assay:GO:0031505 fungal-type cell wall organization [PMID:9363789]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Cell wall mannoprotein; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking; member of the Srp1p/Tip1p family of serine-alanine-rich proteins" /db_xref="GeneID:856729" /db_xref="SGD:S000000813" ORIGIN 1 maytkialfa aiaalasaqt qdqinelnvi lndvkshlqe yislasdsss gfslssmpag 61 vldigmalas atddsyttly sevdfagvsk mltmvpwyss rlepalksln gdasssaaps 121 ssaaptssaa psssaaptss aasssseaks ssaapsssea ksssaapsss eaksssaaps 181 sseaksssaa pssteakits aapsstgakt saisqitdgq iqatkavseq tengaakafv 241 gmgagvvaaa amll // LOCUS NP_010928 198 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit beta 4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010928 VERSION NP_010928.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178903.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07663. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..198 /product="proteasome core particle subunit beta 4" /calculated_mol_wt="22386" Region 1..194 /region_name="proteasome_beta_type_2" /note="proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03758" /db_xref="CDD:239727" CDS 1..198 /gene="PRE1" /locus_tag="YER012W" /coded_by="NM_001178903.1:1..597" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10419517]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:15973433]" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /experiment="EXISTENCE:mutant phenotype:GO:0061133 endopeptidase activator activity [PMID:8808631]" /note="Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle" /db_xref="GeneID:856731" /db_xref="SGD:S000000814" ORIGIN 1 mdiilgirvq dsvilasska vtrgisvlkd sddktrqlsp htlmsfagea gdtvqfaeyi 61 qaniqlysir edyelspqav ssfvrqelak sirsrrpyqv nvliggydkk knkpelyqid 121 ylgtkvelpy gahgysgfyt fslldhhyrp dmtteegldl lklcvqelek rmpmdfkgvi 181 vkivdkdgir qvddfqaq // LOCUS NP_010929 1145 aa linear PLN 30-JUN-2025 DEFINITION DEAH-box ATP-dependent RNA helicase PRP22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010929 VERSION NP_010929.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178904.3 REFERENCE 1 (residues 1 to 1145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1145) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07664. On Jul 30, 2012 this sequence version replaced NP_010929.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1145 /product="DEAH-box ATP-dependent RNA helicase PRP22" /EC_number="3.6.4.13" /calculated_mol_wt="129880" Region <12..58 /region_name="GH2_like" /note="GIPC homology 2 (GH2) domain-like family; cl41749" /db_xref="CDD:425380" Region 75..136 /region_name="GH2_like" /note="GIPC homology 2 (GH2) domain-like family; cd21690" /db_xref="CDD:409667" Region 178..257 /region_name="S1_DHX8_helicase" /note="The N-terminal S1 domain of human ATP-dependent RNA helicase DHX8, a DEAH (Asp-Glu-Ala-His) box polypeptide. The DEAH-box RNA helicases are thought to play key roles in pre-mRNA splicing and DHX8 facilitates nuclear export of spliced mRNA by releasing...; cd05684" /db_xref="CDD:240189" Site order(186,194,208,210) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240189" Region 483..>1097 /region_name="HrpA" /note="HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; COG1643" /db_xref="CDD:441249" CDS 1..1145 /gene="PRP22" /locus_tag="YER013W" /coded_by="NM_001178904.3:1..3438" /experiment="EXISTENCE:direct assay:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:12212850]" /experiment="EXISTENCE:direct assay:GO:0000386 second spliceosomal transesterification activity [PMID:12212850]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:9582286]" /experiment="EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:22408182]" /experiment="EXISTENCE:mutant phenotype:GO:0000386 second spliceosomal transesterification activity [PMID:9524130]" /experiment="EXISTENCE:mutant phenotype:GO:0000390 spliceosomal complex disassembly [PMID:9524130]" /experiment="EXISTENCE:mutant phenotype:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:9524130]" /experiment="EXISTENCE:mutant phenotype:GO:0071021 U2-type post-spliceosomal complex [PMID:12212850]" /note="DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase; associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes; required for proofreading the exon ligation reaction" /db_xref="GeneID:856732" /db_xref="SGD:S000000815" ORIGIN 1 msdiskliga ivgsddpvii efvlniinks gnlqefirni qkldagisye dsikmynafl 61 gkqeeekvrn kvkssplsqk inqvlkddvn lddpvvtefv lsilnksksi tefqeqlnlm 121 qsgldnetif kiyqiasppv mkeevsvlps tkipakieak ieeevqkies ldpspvlhkv 181 yegkvrnitt fgcfvqifgt rmkncdglvh isemsdqrtl dphdvvrqgq hifvevikiq 241 nngkislsmk nidqhsgeir krntesvedr grsndahtsr nmknkikrra ltsperweir 301 qliasgaasi ddypelkdei pintsyltak rddgsivngn tekvdsklee qqrdetdeid 361 velntddgpk flkdqqvkga kkyempkitk vprgfmnrsa ingsnairdh reeklrkkre 421 ieqqirkqqs fddptknkkd srneiqmlkn qlivtewekn rmnesisygk rtslpisaqr 481 qtlpvyamrs eliqavrdnq flvivgetgs gkttqitqyl deegfsnygm igctqprrva 541 avsvakrvae evgckvghdv gytirfedvt gpdtrikymt dgmlqreall dpemskysvi 601 mldeahertv atdvlfallk kaaikrpelk vivtsatlns akfseyflnc piinipgktf 661 pvevlysqtp qmdyieaald cvidihineg pgdilvfltg qeeidsccei lydrvktlgd 721 sigellilpv ysalpseiqs kifeptpkgs rkvvfatnia etsitidgiy yvvdpgfaki 781 niynaragie qlivspisqa qanqrkgrag rtgpgkcyrl ytesafynem lentvpeiqr 841 qnlshtilml kamgindllk fdfmdpppkn lmlnaltely hlqslddegk ltnlgkemsl 901 fpmdptlsrs llssvdnqcs deivtiisml svqnvfyrpk drqleadskk akfhhpygdh 961 ltllnvytrw qqanyseqyc ktnflhfrhl krardvksqi smifkkiglk lischsdpdl 1021 irktfvsgff mnaakrdsqv gyktinggte vgihpsssly gkeyeyvmyh sivltsreym 1081 sqvtsiepqw llevaphfyk agdaesqsrk kakiiplhnk fakdqnswrl ssirqsrera 1141 lgikr // LOCUS NP_010930 539 aa linear PLN 30-JUN-2025 DEFINITION oxygen-dependent protoporphyrinogen oxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010930 VERSION NP_010930.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178905.1 REFERENCE 1 (residues 1 to 539) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 539) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 539) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 539) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07665. Method: conceptual translation. FEATURES Location/Qualifiers source 1..539 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..539 /product="oxygen-dependent protoporphyrinogen oxidase" /EC_number="1.3.3.4" /calculated_mol_wt="59572" Region 24..539 /region_name="proto_IX_ox" /note="protoporphyrinogen oxidase; TIGR00562" /db_xref="CDD:213540" CDS 1..539 /gene="HEM14" /locus_tag="YER014W" /coded_by="NM_001178905.1:1..1620" /experiment="EXISTENCE:direct assay:GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity [PMID:7798202]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7798202]" /experiment="EXISTENCE:mutant phenotype:GO:0004729 oxygen-dependent protoporphyrinogen oxidase activity [PMID:7052077]" /experiment="EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:7035824]" /note="Protoporphyrinogen oxidase; a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides" /db_xref="GeneID:856733" /db_xref="SGD:S000000816" ORIGIN 1 mllpltklkp rakvavvggg vsglcftyfl sklrpdveit lfesqnrtgg wiyscntrdm 61 sgnpimlekg prtlrgvsdg tvlimdtlkd lgkeaviqsi dkgciadkkf lldpsdklvq 121 vpnsisttvk fllnplgkgl itgmmgewfr kksphpgqde svesicdrrf gnnyisnnmi 181 sallrgiygd dvsllsakrt fkkiyynelk hgsntqamid nmrgksrskk tenlhqsltg 241 clndysnafg kdrsklldls ntlkkypmlg laggletfpk ivrnalnefk nvkivtgnpv 301 tqimkrpane ttiglkaksg dqyetfdhlr ltitppkiak llpkdqnsls klldeiqsnt 361 iilvnyylpn kdvidadlqg fgylvpksnk npgkllgvif dsviernfkp lfdklstnpn 421 alnkytkvta miggcmlneh gvpvvpsrev tinavkdaln nhlgisnkdl eagqweftia 481 drclprfhvg ydawqeraer klqesygqtv svggmgfsrs pgvpdvivdg fndalqlsk // LOCUS NP_076437 153 aa linear PLN 30-JUN-2025 DEFINITION Bud25p [Saccharomyces cerevisiae S288C]. ACCESSION NP_076437 VERSION NP_076437.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184456.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07666. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..153 /product="Bud25p" /calculated_mol_wt="17875" CDS 1..153 /gene="BUD25" /locus_tag="YER014C-A" /coded_by="NM_001184456.1:1..462" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:11452010]" /note="Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern" /db_xref="GeneID:856735" /db_xref="SGD:S000007590" ORIGIN 1 mfctwdswdt gtsrkshsph rnclavrflq lpfssflpcv itymkswqts igdsefplts 61 fqilvtdaev vvqrifdcin gylpgwhyrn tvfiehttsy hrshfcifve gvwvcgefvk 121 kwfeipfdnr ienytkqfpw iligfgnqvs kal // LOCUS NP_010931 744 aa linear PLN 30-JUN-2025 DEFINITION medium-chain fatty acid-CoA ligase FAA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010931 VERSION NP_010931.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178906.3 REFERENCE 1 (residues 1 to 744) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 744) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 744) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 744) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07667. On Jul 30, 2012 this sequence version replaced NP_010931.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..744 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..744 /product="medium-chain fatty acid-CoA ligase FAA2" /EC_number="6.2.1.3" /calculated_mol_wt="83307" Region 126..734 /region_name="LC-FACS_euk" /note="Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); cd05927" /db_xref="CDD:341250" Site order(297,300..305,307..308) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341250" Site order(300,420..421,489..494,574,586,589,601,713) /site_type="other" /note="putative AMP binding site [chemical binding]" /db_xref="CDD:341250" Site order(300,345..346,392,394..395,398,420..421,489..494,574, 586,589,598..601,690) /site_type="active" /note="putative active site [active]" /db_xref="CDD:341250" Site order(345,394..395,398,420,598..600,688,690) /site_type="other" /note="putative CoA binding site [chemical binding]" /db_xref="CDD:341250" CDS 1..744 /gene="FAA2" /locus_tag="YER015W" /gene_synonym="FAM1" /coded_by="NM_001178906.3:1..2235" /experiment="EXISTENCE:direct assay:GO:0004467 long-chain fatty acid-CoA ligase activity [PMID:8206942]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:8670886]" /experiment="EXISTENCE:direct assay:GO:0031956 medium-chain fatty acid-CoA ligase activity [PMID:8206942]" /experiment="EXISTENCE:genetic interaction:GO:0001676 long-chain fatty acid metabolic process [PMID:7962057]" /experiment="EXISTENCE:genetic interaction:GO:0031957 very long-chain fatty acid-CoA ligase activity [PMID:9988704]" /experiment="EXISTENCE:mutant phenotype:GO:0001676 long-chain fatty acid metabolic process [PMID:7962057]" /note="Medium chain fatty acyl-CoA synthetase; activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome; comparative analysis suggests that a mitochondrially targeted form may result from translation starting at a non-canonical codon upstream of the annotated start codon" /db_xref="GeneID:856734" /db_xref="SGD:S000000817" ORIGIN 1 maapdyaltd liesdprfes lktrlagytk gsdeyieely sqlpltsypr yktflkkqav 61 aisnpdneag fssiyrssls senlvscvdk nlrtaydhfm fsarrwpqrd clgsrpidka 121 tgtweetfrf esystvskrc hnigsgilsl vntkrkrple andfvvails hnnpewiltd 181 lacqaysltn talyetlgpn tseyilnlte apilifaksn myhvlkmvpd mkfvntlvcm 241 delthdelrm lnesllpvkc nslnekitff sleqveqvgc fnkipaippt pdslytisft 301 sgttglpkgv emshrniasg iafafstfri ppdkrnqqly dmcflplahi fermviaydl 361 aigfgigflh kpdptvlved lkilkpyava lvpriltrfe agiknaldks tvqrnvanti 421 ldsksarfta rggpdksimn flvyhrvlid kirdslglsn nsfiitgsap iskdtllflr 481 saldigirqg ygltetfagv clsepfekdv gscgaigisa ecrlksvpem gyhadkdlkg 541 elqirgpqvf eryfknpnet skavdqdgwf stgdvafidg kgrisvidrv knffklahge 601 yiapekieni ylsscpyitq ifvfgdplkt flvgivgvdv daaqpilaak hpevktwtke 661 vlvenlnrnk klrkeflnki nkctdglqgf eklhnikvgl epltleddvv tptfkikrak 721 askffkdtld qlyaegslvk tekl // LOCUS NP_010932 344 aa linear PLN 30-JUN-2025 DEFINITION microtubule-binding protein BIM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010932 VERSION NP_010932.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178907.1 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07668. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..344 /product="microtubule-binding protein BIM1" /calculated_mol_wt="38231" Region 1..342 /region_name="BIM1" /note="Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]; COG5217" /db_xref="CDD:227542" CDS 1..344 /gene="BIM1" /locus_tag="YER016W" /gene_synonym="YEB1" /coded_by="NM_001178907.1:1..1035" /experiment="EXISTENCE:direct assay:GO:0000922 spindle pole [PMID:10352017]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:10352017]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:20392838]" /experiment="EXISTENCE:direct assay:GO:0035371 microtubule plus-end [PMID:20392838]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:20392838]" /experiment="EXISTENCE:direct assay:GO:0051233 spindle midzone [PMID:10352017]" /experiment="EXISTENCE:direct assay:GO:0072686 mitotic spindle [PMID:10352017]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]" /experiment="EXISTENCE:genetic interaction:GO:0030543 2-micrometer plasmid partitioning [PMID:28004422]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:11285282]" /experiment="EXISTENCE:mutant phenotype:GO:0007019 microtubule depolymerization [PMID:10352017]" /experiment="EXISTENCE:mutant phenotype:GO:0007020 microtubule nucleation [PMID:33752231]" /experiment="EXISTENCE:mutant phenotype:GO:0007026 negative regulation of microtubule depolymerization [PMID:10352017]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:10352017]" /experiment="EXISTENCE:mutant phenotype:GO:0030543 2-micrometer plasmid partitioning [PMID:28004422]" /experiment="EXISTENCE:mutant phenotype:GO:1904825 protein localization to microtubule plus-end [PMID:29576319]" /note="Microtubule plus end-tracking protein; forms a complex with Kar9p that makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; homolog of human end binding protein 1 (EB1)" /db_xref="GeneID:856736" /db_xref="SGD:S000000818" ORIGIN 1 msagigesrt elltwlngll nlnykkieec gtgaaycqim dsiygdlpmn rvkfnataey 61 efqtnykilq scfsrhgiek tvyvdklirc kfqdnleflq wlkkhwirhk desvydpdar 121 rkyrpiitnn satkprtvsn pttakrssst gtgsamsggl atrhsslgin gsrktsvtqg 181 qlvaiqaelt ksqetigsln eeieqykgtv stleierefy fnklrdieil vhttqdline 241 gvykfndeti tghgngngga llrfvkkves ilyataegfe mndgedelnd knlgehgtvp 301 nqggyansng evngnegsnh dvimqndege vgvsnnliid eetf // LOCUS NP_010933 761 aa linear PLN 30-JUN-2025 DEFINITION AAA family ATPase AFG3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010933 VERSION NP_010933.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178908.1 REFERENCE 1 (residues 1 to 761) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 761) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 761) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 761) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07669. Method: conceptual translation. FEATURES Location/Qualifiers source 1..761 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..761 /product="AAA family ATPase AFG3" /calculated_mol_wt="84413" Region 124..215 /region_name="FtsH_ext" /note="FtsH Extracellular; pfam06480" /db_xref="CDD:377663" Region 223..730 /region_name="FtsH_fam" /note="ATP-dependent metalloprotease FtsH; TIGR01241" /db_xref="CDD:273520" CDS 1..761 /gene="AFG3" /locus_tag="YER017C" /gene_synonym="YTA10" /coded_by="NM_001178908.1:1..2286" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7926051]" /experiment="EXISTENCE:direct assay:GO:0005745 m-AAA complex [PMID:8681382]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:19748354]" /experiment="EXISTENCE:direct assay:GO:0097002 mitochondrial inner boundary membrane [PMID:19019989]" /experiment="EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:12417197]" /experiment="EXISTENCE:mutant phenotype:GO:0008237 metallopeptidase activity [PMID:8681382]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:19748354]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:27398316]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:8681382]" /note="Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; involved in cytoplasmic mRNA translation and aging; expression of human homolog AFG3L2 can complement yeast yta12 afg3 double mutant" /db_xref="GeneID:856737" /db_xref="SGD:S000000819" ORIGIN 1 mmmwqryarg aprsltslsf gkasristvk pvlrsrmpvh qrlqtlsgla trntihrstq 61 irsfhiswtr lnenrpnkeg egknngnkdn nsnkedgkdk rnefgslsey frskefantm 121 fltigftiif tlltpssnns gddsnrvltf qdfktkylek glvskiyvvn kflveaelvn 181 tkqvvsftig svdifeeqmd qiqdllnipp rdripikyie rsspftflfp flptiillgg 241 lyfitrkins sppnangggg gglggmfnvg ksraklfnke tdikisfknv agcdeakqei 301 mefvhflknp gkytklgaki prgailsgpp gtgktllaka tageanvpfl svsgsefvem 361 fvgvgasrvr dlftqarsma psiifideid aigkergkgg alggandere atlnqllvem 421 dgfttsdqvv vlagtnrpdv ldnalmrpgr fdrhiqidsp dvngrqqiyl vhlkrlnldp 481 lltddmnnls gklatltpgf tgadianacn eaaliaarhn dpyitihhfe qaierviagl 541 ekktrvlske ekrsvayhea ghavcgwflk yadpllkvsi iprgqgalgy aqylppdqyl 601 iseeqfrhrm imalggrvse elhfpsvtsg ahddfkkvtq manamvtslg mspkigylsf 661 dqndgnfkvn kpfsnktart idlevksivd dahractell tknldkvdlv akellrkeai 721 tredmirllg prpfkernea fekyldpksn teppeapaat n // LOCUS NP_010934 221 aa linear PLN 30-JUN-2025 DEFINITION kinetochore-associated Ndc80 complex subunit SPC25 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010934 VERSION NP_010934.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178909.3 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07670. On Jul 30, 2012 this sequence version replaced NP_010934.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..221 /product="kinetochore-associated Ndc80 complex subunit SPC25" /calculated_mol_wt="25113" Region <22..>148 /region_name="Smc" /note="Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; COG1196" /db_xref="CDD:440809" Region 133..214 /region_name="RWD_DRWD_ELF-like" /note="RWD, DRWD, and ELF domain family; cl45901" /db_xref="CDD:480265" CDS 1..221 /gene="SPC25" /locus_tag="YER018C" /coded_by="NM_001178909.3:1..666" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11511347]" /experiment="EXISTENCE:direct assay:GO:0031262 Ndc80 complex [PMID:11266451|PMID:11179222]" /experiment="EXISTENCE:mutant phenotype:GO:0000776 kinetochore [PMID:11179222]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11266451]" /experiment="EXISTENCE:mutant phenotype:GO:0098653 centromere clustering [PMID:11179222]" /experiment="EXISTENCE:physical interaction:GO:0031262 Ndc80 complex [PMID:11179222]" /note="Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p" /db_xref="GeneID:856738" /db_xref="SGD:S000000820" ORIGIN 1 masidafsdl errmdgfqkd vaqvlarqqn harqqlqqfq aemrqlhnqh qhlidelqrl 61 atqrtalqqq ihaaqqatnt treqwrsyhe reselsrrqs tlaaqsreld sllqqrgkec 121 vqlrarwaaq sgndaaeval yerllqlrvl pgasdvhdvr fvfgddsrcw ievamhgdhv 181 ignshpaldp ksratlehvl tvqgdlaafl vvardmllas l // LOCUS NP_010935 477 aa linear PLN 30-JUN-2025 DEFINITION inositol phosphosphingolipid phospholipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010935 VERSION NP_010935.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178910.1 REFERENCE 1 (residues 1 to 477) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 477) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 477) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 477) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07671. Method: conceptual translation. FEATURES Location/Qualifiers source 1..477 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..477 /product="inositol phosphosphingolipid phospholipase" /calculated_mol_wt="53810" Region 41..341 /region_name="EEP" /note="Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; cl00490" /db_xref="CDD:469791" Site order(45,100,188,231,233,302,333..334) /site_type="active" /note="putative catalytic site [active]" /db_xref="CDD:197306" Site order(100,333) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:197306" Site order(188,233,334) /site_type="other" /note="putative phosphate binding site [ion binding]" /db_xref="CDD:197306" CDS 1..477 /gene="ISC1" /locus_tag="YER019W" /coded_by="NM_001178910.1:1..1434" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14699160]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:17880915]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14699160]" /experiment="EXISTENCE:direct assay:GO:0030149 sphingolipid catabolic process [PMID:11006294]" /experiment="EXISTENCE:direct assay:GO:0052712 inositol phosphosphingolipid phospholipase activity [PMID:11006294]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0046513 ceramide biosynthetic process [PMID:17880915|PMID:23620586]" /experiment="EXISTENCE:mutant phenotype:GO:0072711 cellular response to hydroxyurea [PMID:23620586]" /experiment="EXISTENCE:mutant phenotype:GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint [PMID:32205408]" /note="Inositol phosphosphingolipid phospholipase C; hydrolyzes complex sphingolipids to produce ceramide; regulates the spindle assembly checkpoint upstream of PP2A-Cdc55; activates genes required for non-fermentable carbon source metabolism during the diauxic shift; mediates Na+ and Li+ halotolerance; activated by phosphatidylserine, cardiolipin and phosphatidylglycerol; mitochondrial outer membrane protein; ortholog of mammalian neutral sphingomyelinase type 2" /db_xref="GeneID:856739" /db_xref="SGD:S000000821" ORIGIN 1 mynrkdrdvh erkedgqsef ealngtnaim sdnskaysik fltfntwglk yvskhrkerl 61 raiadklagh smltpisdel lpnggdsnen edydvialqe iwcvedwkyl asacaskypy 121 qrlfhsgilt gpglailskv piestflyrf pingrpsavf rgdwyvgksi aitvlntgtr 181 piaimnshmh apyakqgdaa ylchrscqaw dfsrliklyr qagyavivvg dlnsrpgslp 241 hkfltqeagl vdsweqlhgk qdlaviarls plqqllkgct tcdsllntwr aqrqpdeacr 301 ldyalidpdf lqtvdagvrf teriphldcs vsdhfaysct lnivpqgtes rpstsvkrak 361 thdrelilqr ysnyetmiec ihtylktaqr qkffrglhfw asillliasl vvttftanka 421 gwssifwvlf aiavsisgti dgaisflfgr seiralieve qevldaehhl qtflsek // LOCUS NP_010936 88 aa linear PLN 30-JUN-2025 DEFINITION Arf family guanine nucleotide exchange factor SBH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010936 VERSION NP_010936.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180031.1 REFERENCE 1 (residues 1 to 88) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 88) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 88) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 88) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07672. Method: conceptual translation. FEATURES Location/Qualifiers source 1..88 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..88 /product="Arf family guanine nucleotide exchange factor SBH2" /calculated_mol_wt="9475" Region 45..81 /region_name="Sec61_beta" /note="Sec61beta family; pfam03911" /db_xref="CDD:427582" CDS 1..88 /gene="SBH2" /locus_tag="YER019C-A" /gene_synonym="SEB2" /coded_by="NM_001180031.1:1..267" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:12750387]" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0071261 Ssh1 translocon complex [PMID:8612571]" /experiment="EXISTENCE:genetic interaction:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:18347066]" /note="Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog, SBH1, that arose from the whole genome duplication" /db_xref="GeneID:856740" /db_xref="SGD:S000002127" ORIGIN 1 maasvppggq rilqkrrqaq sikekqakqt ptstrqagyg gssssilkly tdeangfrvd 61 slvvlflsvg fifsvialhl ltkfthii // LOCUS NP_010937 449 aa linear PLN 30-JUN-2025 DEFINITION guanine nucleotide-binding protein subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_010937 VERSION NP_010937.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178911.3 REFERENCE 1 (residues 1 to 449) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 449) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 449) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 449) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07673. On Jul 30, 2012 this sequence version replaced NP_010937.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..449 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..449 /product="guanine nucleotide-binding protein subunit alpha" /calculated_mol_wt="50317" Region 124..442 /region_name="G-alpha" /note="Alpha subunit of G proteins (guanine nucleotide binding); cd00066" /db_xref="CDD:206639" Site order(130,135..137,276,296,299,365..366,368,419..420) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206639" Site 130..137 /site_type="other" /note="G1 box" /db_xref="CDD:206639" Site order(131..133,161,165,169,172,175..176,196,199,244,273, 299,307,311) /site_type="active" /note="GoLoco binding site [active]" /db_xref="CDD:206639" Site 271..279 /site_type="other" /note="Switch I region" /db_xref="CDD:206639" Site 276 /site_type="other" /note="G2 box" /db_xref="CDD:206639" Site order(277,279,281,293,295,299..301,303,306..307,309..312) /site_type="other" /note="beta - gamma complex interaction site [polypeptide binding]" /db_xref="CDD:206639" Site order(279,305,308..309,312) /site_type="other" /note="adenylyl cyclase interaction site [polypeptide binding]" /db_xref="CDD:206639" Site 296..299 /site_type="other" /note="G3 box" /db_xref="CDD:206639" Site 297..313 /site_type="other" /note="Switch II region" /db_xref="CDD:206639" Site 365..368 /site_type="other" /note="G4 box" /db_xref="CDD:206639" Site order(411..422,424..427) /site_type="active" /note="putative receptor binding site [active]" /db_xref="CDD:206639" Site 419..421 /site_type="other" /note="G5 box" /db_xref="CDD:206639" CDS 1..449 /gene="GPA2" /locus_tag="YER020W" /gene_synonym="SSP101" /coded_by="NM_001178911.3:1..1350" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16924114]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:31690628]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16030250|PMID:31690628|PMID:16622836]" /experiment="EXISTENCE:genetic interaction:GO:0010255 glucose mediated signaling pathway [PMID:2830616|PMID:10361302]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:9384580]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:10655215|PMID:10454558|PMID:9384580]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:10454558]" /experiment="EXISTENCE:mutant phenotype:GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway [PMID:9628870]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0009757 hexose mediated signaling [PMID:10655215]" /experiment="EXISTENCE:mutant phenotype:GO:0010255 glucose mediated signaling pathway [PMID:9628870|PMID:2830616]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:10454558]" /experiment="EXISTENCE:physical interaction:GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway [PMID:16924114]" /note="Nucleotide binding alpha subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p, has signaling role in response to nutrients; required for the recruitment of Ras-GTP at the plasma membrane and in the nucleus" /db_xref="GeneID:856741" /db_xref="SGD:S000000822" ORIGIN 1 mglcassekn gstpdtqtas agsdnvgkak vppkqepqkt vrtvntanqq ekqqqrqqqp 61 sphnvkdrke qngsinnais ptatantsgs qqinidsalr drssnvaaqp slsdassgsn 121 dkelkvlllg agesgkstvl qqlkilhqng fseqeikeyi pliyqnllei grnliqartr 181 fnvnlepece ltqqdlsrtm syempnnytg qfpediagvi stlwalpstq dlvngpnask 241 fylmdstpyf menftritsp nyrptqqdil rsrqmtsgif dtvidmgsdi kmhiydvggq 301 rserkkwihc fdnvtlvifc vslseydqtl medknqnrfq eslvlfdniv nsrwfartsv 361 vlflnkidlf aeklskvpme nyfpdytggs dinkaakyil wrfvqlnran lsiyphvtqa 421 tdtsnirlvf aaiketilen tlkdsgvlq // LOCUS NP_010938 523 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle lid subunit RPN3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010938 VERSION NP_010938.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178912.1 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07674. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..523 /product="proteasome regulatory particle lid subunit RPN3" /calculated_mol_wt="60262" Region 343..447 /region_name="PCI" /note="PCI domain; pfam01399" /db_xref="CDD:460195" Region 450..509 /region_name="Rpn3_C" /note="Proteasome regulatory subunit C-terminal; pfam08375" /db_xref="CDD:462452" CDS 1..523 /gene="RPN3" /locus_tag="YER021W" /gene_synonym="SUN2" /coded_by="NM_001178912.1:1..1572" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:9741626]" /note="Essential non-ATPase regulatory subunit of the 26S proteasome lid; similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control" /db_xref="GeneID:856742" /db_xref="SGD:S000000823" ORIGIN 1 mastavmmdv dssgvndlhh sekkyaeedq vqellkvlne iskttltldp ryiwrslkdl 61 sslrnqelln aetlcftvnv lypdsssfkk nllkfitsnh kssvpgsael rnsypasfys 121 vntekktiev taeincfmhl lvqlflwdsk eleqlvefnr kvvipnllcy ynlrslnlin 181 aklwfyiyls hetlarssee insdnqniil rstmmkflki aslkhdnetk amlinlilrd 241 flnngevdsa sdfiskleyp htdvssslea ryffylskin aiqldystan eyiiaairka 301 phnskslgfl qqsnklhcci qllmgdipel sffhqsnmqk sllpyyhltk avklgdlkkf 361 tstitkykql llkddtyqlc vrlrsnvikt giriisltyk kislrdiclk lnldseqtve 421 ymvsrairdg vieakinhed gfiettelln iydsedpqqv fderikfanq lhdeylvsmr 481 ypedkktqqn eksengendd dtldgdlmdd msdisdlddl gfl // LOCUS NP_010939 687 aa linear PLN 30-JUN-2025 DEFINITION Srb4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010939 VERSION NP_010939.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178913.1 REFERENCE 1 (residues 1 to 687) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 687) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 687) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 687) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07675. Method: conceptual translation. FEATURES Location/Qualifiers source 1..687 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..687 /product="Srb4p" /calculated_mol_wt="78345" Region 86..569 /region_name="Med17" /note="Subunit 17 of Mediator complex; pfam10156" /db_xref="CDD:401965" CDS 1..687 /gene="SRB4" /locus_tag="YER022W" /gene_synonym="MED17" /coded_by="NM_001178913.1:1..2064" /experiment="EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8187178]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:direct assay:GO:0140297 DNA-binding transcription factor binding [PMID:9660972]" /experiment="EXISTENCE:mutant phenotype:GO:0001139 RNA polymerase II complex recruiting activity [PMID:19805365]" /experiment="EXISTENCE:mutant phenotype:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:16263706]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:33789343]" /experiment="EXISTENCE:physical interaction:GO:0001139 RNA polymerase II complex recruiting activity [PMID:21415355]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for basal RNA polymerase II transcription; homozygosity of the human MED17 L371P mutation is associated with infantile cerebral and cerebellar atrophy with poor myelination" /db_xref="GeneID:856743" /db_xref="SGD:S000000824" ORIGIN 1 mttedpdsnh lssetgikla ldpnlitlal ssnpnsslhs ptsdepvpes agkadtsirl 61 egdelenktk kdndknlkfl knkdslvsnp heiygsmple qlipiilrqr gpgfkfvdln 121 ekelqneikq lgsdssdghn sekkdtdgad envqigedfm evdyedkdnp vdsrnetdhk 181 tnengetddn ietvmtqeqf vkrrrdmleh inlamnessl alefvsllls svkestgmss 241 mspflrkvvk psslnsdkip yvaptkkeyi eldilnkgwk lqslneskdl lrasfnklss 301 ilqnehdywn kimqsisnkd vifkirdrts gqkllaikyg yedsgstykh drgianirnn 361 iesqnldlip hsssvfkgtd fvhsvkkflr vriftkiese ddyilsgesv mdrdseseea 421 etkdirkqiq llkkiifeke lmyqikkeca llisygvsie nenkviielp nekfeiells 481 ldddsivnhe qdlpkindkr anlmlvmlrl llvvifkktl rsrissphgl inlnvdddil 541 iirpilgkvr fanyklllkk iikdyvldiv pgssitetev ereqpqenkn iddenitkln 601 keirafdkll niprrelkin lpltehkspn lslmlespny cnalihikfs agteanavsf 661 dttfsdfkev edflhfivae yiqqkkv // LOCUS NP_010940 286 aa linear PLN 30-JUN-2025 DEFINITION pyrroline-5-carboxylate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010940 VERSION NP_010940.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178914.3 REFERENCE 1 (residues 1 to 286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 286) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07676. On Jul 30, 2012 this sequence version replaced NP_010940.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..286 /product="pyrroline-5-carboxylate reductase" /EC_number="1.5.1.2" /calculated_mol_wt="30001" Region 30..280 /region_name="proC" /note="pyrroline-5-carboxylate reductase; TIGR00112" /db_xref="CDD:272911" CDS 1..286 /gene="PRO3" /locus_tag="YER023W" /gene_synonym="ORE2" /coded_by="NM_001178914.3:1..861" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7009582]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:25112878]" /experiment="EXISTENCE:mutant phenotype:GO:0004735 pyrroline-5-carboxylate reductase activity [PMID:1508147|PMID:2824433]" /experiment="EXISTENCE:mutant phenotype:GO:0006561 proline biosynthetic process [PMID:2824433|PMID:1508147]" /note="Cytosolic delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis" /db_xref="GeneID:856744" /db_xref="SGD:S000000825" ORIGIN 1 mtytlailgc gvmgqallsa iynapkaade taaafypski itcnhdepsa qqvtdlvetf 61 despngikve styghnvsav eeasvvllgt kpflaeevln gvksviggkl lislaagwti 121 dqlsqytstv crvmtntpak ygygcavvsy sadvskeqkp lvnelisqvg kyvelpeknm 181 daatalvgsg pafvllmles lmesglklgi plqeskecam kvlegtvkmv eksgahpsvl 241 khqvctpggt tiaglcvmee kgvksgiing veeaarvasq lgqkkk // LOCUS NP_010941 923 aa linear PLN 30-JUN-2025 DEFINITION carnitine O-acetyltransferase YAT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010941 VERSION NP_010941.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178915.1 REFERENCE 1 (residues 1 to 923) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 923) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 923) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 923) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 923) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07677. Method: conceptual translation. FEATURES Location/Qualifiers source 1..923 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..923 /product="carnitine O-acetyltransferase YAT2" /EC_number="2.3.1.7" /calculated_mol_wt="103203" Region 26..725 /region_name="Carn_acyltransf" /note="Choline/Carnitine o-acyltransferase; pfam00755" /db_xref="CDD:459926" CDS 1..923 /gene="YAT2" /locus_tag="YER024W" /coded_by="NM_001178915.1:1..2772" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18427809]" /experiment="EXISTENCE:mutant phenotype:GO:0004092 carnitine O-acetyltransferase activity [PMID:11329169]" /experiment="EXISTENCE:mutant phenotype:GO:0006066 alcohol metabolic process [PMID:11329169]" /experiment="EXISTENCE:mutant phenotype:GO:0009437 carnitine metabolic process [PMID:11329169]" /note="Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane" /db_xref="GeneID:856745" /db_xref="SGD:S000000826" ORIGIN 1 mssgstivss dksgrtfkhe eelpklplpk lcdtlqrlke sleplyyadg yyqhpldpeq 61 ieklssiird feenpvsekl qsklqsyhdt rdcyldelhl dinnqtstre iqddvlprnp 121 flvladdalp nitqadrsav lvhsaarfis alkqdllppd inatngkpls mapflnlfgt 181 trspvfqrge venfdlnkpy tasdledpdy ssdeddndep tqkdfddrkr kheediftgn 241 gitikrhpds khiliisrgq yytlevldst nkiiytaael ttifnhiikd ssgiekstal 301 gsltshsfrn wkyarkrlqk rypnelhrid salfvlvlde sqeettndgd dtadisqmfn 361 rtiterdkkc tsanckrvfy gtsiinskgh qvgscvsrwy dklqlvvtad akatviwdsf 421 tcdgsvvlrf tseiytesvl rlardvnagd pqfslwpnvt qmdpetkklm tatisadggg 481 pseidpklvv nkidwsfsni lnthvhlset kladliskyd ivrasiplgr rsaqrlgvkp 541 dsmvqvalqi ahyalygrmv fglepvstrg fknsrssfin iqsqallelc qlfisssidg 601 tdkldkfiqt cethnnmvkh aksgvgyekh fnalkylfkf hdhfgihlsg dessaakdlf 661 enplvlpfsq pelivancgn aatttfgitp avphgfgigy iikddqvdlt vtsqfrqgdr 721 lmfmlswvlg eirsywrmsr gtshnktgvk ispvvdklye mdnavnnppk rnghtvngsr 781 ktssssqvnl nryggffdle ghidsrnisk tpsmknlqkt fngltmsadn dhsssavsvp 841 tekeklntgh eilqiqprev asngleadde tdieivagna dgtsssassa tslnskkrnv 901 insrfdidfd rsrvgrkvat ldq // LOCUS NP_010942 527 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF2 subunit gamma [Saccharomyces cerevisiae S288C]. ACCESSION NP_010942 VERSION NP_010942.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178916.1 REFERENCE 1 (residues 1 to 527) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 527) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 527) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 527) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07678. Method: conceptual translation. FEATURES Location/Qualifiers source 1..527 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..527 /product="translation initiation factor eIF2 subunit gamma" /EC_number="3.6.5.3" /calculated_mol_wt="57735" Region 74..524 /region_name="PTZ00327" /note="eukaryotic translation initiation factor 2 gamma subunit; Provisional" /db_xref="CDD:240362" CDS 1..527 /gene="GCD11" /locus_tag="YER025W" /gene_synonym="SUI4" /coded_by="NM_001178916.1:1..1584" /experiment="EXISTENCE:direct assay:GO:0001731 formation of translation preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:14698289|PMID:16246727]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:22683627]" /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:15838098|PMID:11018020]" /experiment="EXISTENCE:direct assay:GO:1990856 methionyl-initiator methionine tRNA binding [PMID:16565414]" /experiment="EXISTENCE:mutant phenotype:GO:0000049 tRNA binding [PMID:8947054]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:23063529]" /experiment="EXISTENCE:mutant phenotype:GO:0005525 GTP binding [PMID:8947054]" /experiment="EXISTENCE:mutant phenotype:GO:0005850 eukaryotic translation initiation factor 2 complex [PMID:8417348]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:23063529]" /experiment="EXISTENCE:mutant phenotype:GO:0045903 positive regulation of translational fidelity [PMID:9308967]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:22683627]" /note="Gamma subunit of the translation initiation factor eIF2; involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met; mutations in human ortholog cause X-linked intellectual disability (XLID) syndrome" /db_xref="GeneID:856746" /db_xref="SGD:S000000827" ORIGIN 1 msdlqdqeps iiingnlepv gepdiveete vvaqetqetq dadkpkkkva ftgleedget 61 eeekrkrefe eggglpeqpl npdfsklnpl saeiinrqat inigtighva hgkstvvrai 121 sgvqtvrfkd elernitikl gyanakiykc qeptcpepdc yrsfksdkei spkcqrpgcp 181 gryklvrhvs fvdcpghdil mstmlsgaav mdaallliag nescpqpqts ehlaaieimk 241 lkhviilqnk vdlmreesal ehqksilkfi rgtiadgapi vpisaqlkyn idavnefivk 301 tipvpprdfm isprlivirs fdvnkpgaei edlkggvagg silngvfklg deieirpgiv 361 tkddkgkiqc kpifsnivsl faeqndlkfa vpggligvgt kvdptlcrad rlvgqvvgak 421 ghlpniytdi einyfllrrl lgvktdgqkq akvrklepne vlmvnigsta tgarvvavka 481 dmarlqltsp acteinekia lsrriekhwr ligwatikkg ttlepia // LOCUS NP_010943 276 aa linear PLN 30-JUN-2025 DEFINITION CDP-diacylglycerol-serine O-phosphatidyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010943 VERSION NP_010943.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178917.3 REFERENCE 1 (residues 1 to 276) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 276) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 276) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 276) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07679. On Jul 30, 2012 this sequence version replaced NP_010943.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..276 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..276 /product="CDP-diacylglycerol-serine O-phosphatidyltransferase" /EC_number="2.7.8.8" /calculated_mol_wt="30674" Region 87..242 /region_name="pssA" /note="CDP-diacylglycerol--serine O-phosphatidyltransferase; TIGR00473" /db_xref="CDD:273098" CDS 1..276 /gene="CHO1" /locus_tag="YER026C" /gene_synonym="PSS1" /coded_by="NM_001178917.3:1..831" /experiment="EXISTENCE:direct assay:GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity [PMID:6088519]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:3005242]" /experiment="EXISTENCE:direct assay:GO:0006659 phosphatidylserine biosynthetic process [PMID:6088519]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:6274497]" /experiment="EXISTENCE:mutant phenotype:GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity [PMID:6988386]" /experiment="EXISTENCE:mutant phenotype:GO:0006659 phosphatidylserine biosynthetic process [PMID:3031455|PMID:6988386]" /note="Phosphatidylserine synthase; functions in phospholipid biosynthesis; transcriptionally repressed by myo-inositol and choline" /db_xref="GeneID:856748" /db_xref="SGD:S000000828" ORIGIN 1 mvesdedfap qefphtdtdv ivnehrdend gyasdevggt lsrrassifs inttplappn 61 atdiqkftsd ehhfsmmrnl hmadyitmln gfsgfysivs clrftltgkp hyvqrahffi 121 llgmcfdfld grvarlrnrs slmgqeldsl adlvsfgvap aaiafaigfq ttfdvmilsf 181 fvlcglarla rfnvtvaqlp kdsstgksky feglpmpttl alvlgmaycv rkglifdnip 241 fgifredqil efhpiilvff ihgcgmisks lkipkp // LOCUS NP_010944 417 aa linear PLN 30-JUN-2025 DEFINITION Gal83p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010944 VERSION NP_010944.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178918.1 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07680. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..417 /product="Gal83p" /calculated_mol_wt="46517" Region 163..247 /region_name="AMPK1_CBM" /note="Glycogen recognition site of AMP-activated protein kinase; pfam16561" /db_xref="CDD:465176" Region 306..416 /region_name="AMPKBI" /note="5'-AMP-activated protein kinase beta subunit, interation domain; smart01010" /db_xref="CDD:214973" CDS 1..417 /gene="GAL83" /locus_tag="YER027C" /gene_synonym="SPM1" /coded_by="NM_001178918.1:1..1254" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11331606|PMID:17237508]" /experiment="EXISTENCE:direct assay:GO:0005641 nuclear envelope lumen [PMID:17237508]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17237508]" /experiment="EXISTENCE:direct assay:GO:0031588 nucleotide-activated protein kinase complex [PMID:12393914]" /experiment="EXISTENCE:genetic interaction:GO:0004679 AMP-activated protein kinase activity [PMID:10990457]" /experiment="EXISTENCE:genetic interaction:GO:0007165 signal transduction [PMID:10990457]" /experiment="EXISTENCE:genetic interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:9121458]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12556493]" /experiment="EXISTENCE:mutant phenotype:GO:0004679 AMP-activated protein kinase activity [PMID:7813428]" /experiment="EXISTENCE:mutant phenotype:GO:0007155 cell adhesion [PMID:12556493]" /experiment="EXISTENCE:physical interaction:GO:0031588 nucleotide-activated protein kinase complex [PMID:9121458|PMID:7813428]" /note="One of three alternate beta-subunits of the Snf1 kinase complex; allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; necessary and sufficient for phosphorylation of the Mig2p transcription factor in response to alkaline stress; functionally redundant with SIP1 and SIP2 for the phosphorylation of Mig1p in response to glucose deprivation; contains a glycogen-binding domain" /db_xref="GeneID:856749" /db_xref="SGD:S000000829" ORIGIN 1 magdnpenkd asmldvsdaa snttingkhs adstneasla ytfsqmnvdn pnelepqhpl 61 rhksslifnd ddddeippys nhaengsget fdsdddidas ssssidsneg dihdadmtgn 121 tlqkmdyqps qqpdslqnqg fqqqqeqqqg tvegkkgram mfpvditwqq ggnkvyvtgs 181 ftgwrkmigl vpvpgqpglm hvklqlppgt hrfrfivdne lrfsdylpta tdqmgnfvny 241 mevsappdwg nepqqhlaek kanhvddskl skrpmsarsr ialeiekepd dmgdgytrfh 301 detpakpnle ytqdipavft dpnvmeqyyl tldqqqnnhq nmawltppql pphlenviln 361 sysnaqtdnt sgalpipnhv ilnhlatssi khntlcvasi vrykqkyvtq ilytplq // LOCUS NP_010945 394 aa linear PLN 30-JUN-2025 DEFINITION Mig3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010945 VERSION NP_010945.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178919.1 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07681. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..394 /product="Mig3p" /calculated_mol_wt="42988" Region 1..394 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 19..39 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 47..69 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..394 /gene="MIG3" /locus_tag="YER028C" /coded_by="NM_001178919.1:1..1185" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:19680226]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9832517|PMID:12239282]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19680226]" /experiment="EXISTENCE:genetic interaction:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:19680226|PMID:14993292]" /experiment="EXISTENCE:genetic interaction:GO:0034644 cellular response to UV [PMID:19680226]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19680226]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:23275883]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:19680226]" /experiment="EXISTENCE:mutant phenotype:GO:0045471 response to ethanol [PMID:23275883]" /note="Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes" /db_xref="GeneID:856750" /db_xref="SGD:S000000830" ORIGIN 1 mnylrdrfpp dndqrpfrce icsrgfhrle hkkrhgrtht gekphkctvq gcpksfsrsd 61 elkrhlrtht kgvqrrriks kgsrktvvnt ataapttfne ntgvsltgig qskvppilis 121 vaqncddvni rntgnnngiv etqapailvp vinipndphp ipsslsttsi tsiasvypst 181 spfqylksgf pedpastpyv hssgsslalg elssnssifs ksrrnlaams gpdslssskn 241 qssasllsqt shpsksfsrp ptdlsplrri mpsvntgdme isrtvsvsss sssltsvtyd 301 dtaakdmgmg iffdrppvtq kacrsnhkyk vnavsrgrqh eraqfhisgd dedsnvhrqe 361 srasntspnv slppiksilr qidnfnsaps yfsk // LOCUS NP_010946 196 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SMB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010946 VERSION NP_010946.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178920.3 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07682. On Jul 30, 2012 this sequence version replaced NP_010946.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..196 /product="mRNA splicing protein SMB1" /calculated_mol_wt="22248" Region 8..98 /region_name="Sm_B" /note="Sm protein B; cd01717" /db_xref="CDD:212464" Site order(11,17,25..26,35,39,46..47,84..97) /site_type="other" /note="heptamer interface [polypeptide binding]" /db_xref="CDD:212464" Site order(20..26,28..40,42..46) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212464" Site order(23..28,30,36..37,40,42,44,75,80,82,84..94) /site_type="other" /note="putative hexamer interface [polypeptide binding]" /db_xref="CDD:212464" Site order(39..42,52,74..76,88,90) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:212464" Site 84..95 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212464" CDS 1..196 /gene="SMB1" /locus_tag="YER029C" /coded_by="NM_001178920.3:1..591" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720285|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /note="Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B'" /db_xref="GeneID:856751" /db_xref="SGD:S000000831" ORIGIN 1 mskiqvahss rlanlidykl rvltqdgrvy igqlmafdkh mnlvlnecie ervpktqldk 61 lrprkdskdg ttlnikvekr vlgltilrge qilstvvedk pllskkerlv rdkkekkqaq 121 kqtklrkeke kkpgkiakpn tanakhtssn sreiaqpsss rynggndnig anrsrfnnea 181 ppqtrkfqpp pgfkrk // LOCUS NP_010947 153 aa linear PLN 30-JUN-2025 DEFINITION Chz1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010947 VERSION NP_010947.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178921.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07683. On Dec 12, 2005 this sequence version replaced NP_010947.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..153 /product="Chz1p" /calculated_mol_wt="17331" Region <97..120 /region_name="CHZ" /note="Histone chaperone domain CHZ; pfam09649" /db_xref="CDD:462846" CDS 1..153 /gene="CHZ1" /locus_tag="YER030W" /coded_by="NM_001178921.1:1..462" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:17289584]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:17289584]" /experiment="EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:17289584]" /note="Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856752" /db_xref="SGD:S000000832" ORIGIN 1 msdeakekre lesqkesshn kseksvepkp krrrrrnydd ydaevakeet kakngltkse 61 nngtvedses dmddakldal mgnegeeeed dlaeidtsni itsgrrtrgk vidykktaee 121 ldkkepstgs kddvgygeke eddedeeddd fke // LOCUS NP_010948 223 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase YPT31 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010948 VERSION NP_010948.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178922.1 REFERENCE 1 (residues 1 to 223) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 223) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 223) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 223) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07684. Method: conceptual translation. FEATURES Location/Qualifiers source 1..223 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..223 /product="Rab family GTPase YPT31" /calculated_mol_wt="24338" Region 11..175 /region_name="Rab11_like" /note="Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25; cd01868" /db_xref="CDD:206660" Site 11..15 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206660" Site 20..27 /site_type="other" /note="G1 box" /db_xref="CDD:206660" Site order(22..28,39,42,45,71,126..127,129,156..158) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206660" Site order(28..39,41..44) /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206660" Site order(38,43..51) /site_type="other" /note="Switch I region" /db_xref="CDD:206660" Site order(43,47..54,61,63) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206660" Site 45 /site_type="other" /note="G2 box" /db_xref="CDD:206660" Site order(46,48..50,65,67,74..75,78,82,84..87,174) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206660" Site order(46..47,49,67..68,75,77,79..81) /site_type="other" /note="putative GDI interaction site [polypeptide binding]" /db_xref="CDD:206660" Site 46..50 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206660" Site 63..67 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206660" Site 68..71 /site_type="other" /note="G3 box" /db_xref="CDD:206660" Site order(71,73..83) /site_type="other" /note="Switch II region" /db_xref="CDD:206660" Site 74..79 /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206660" Site 82..86 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206660" Site 91..96 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206660" Site 119..123 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206660" Site 126..129 /site_type="other" /note="G4 box" /db_xref="CDD:206660" Site 156..158 /site_type="other" /note="G5 box" /db_xref="CDD:206660" Site 172..175 /site_type="other" /note="Rab subfamily motif 4 (RabSF4)" /db_xref="CDD:206660" CDS 1..223 /gene="YPT31" /locus_tag="YER031C" /gene_synonym="YPT8" /coded_by="NM_001178922.1:1..672" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:15537705]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15537705]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:26906739]" /experiment="EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:15537705]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:9151665]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:9151665]" /note="Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication; localizes to the transitional and late Golgi" /db_xref="GeneID:856753" /db_xref="SGD:S000000833" ORIGIN 1 mssedygydy dllfkivlig dsgvgksnll srftknefnm dskstigvef atrtleidgk 61 rikaqiwdta gqeryraits ayyrgavgal ivydisksss yencnhwlse lrenaddnva 121 vglignksdl ahlravptee sktfaqenql lftetsalns envdkafeel intiyqkvsk 181 hqmdlgdssa ngnangasap ngptisltpt pnenkkangn ncc // LOCUS NP_010949 876 aa linear PLN 30-JUN-2025 DEFINITION Fir1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010949 VERSION NP_010949.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178923.3 REFERENCE 1 (residues 1 to 876) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 876) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 876) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 876) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07685. On Jul 30, 2012 this sequence version replaced NP_010949.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..876 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..876 /product="Fir1p" /calculated_mol_wt="98681" CDS 1..876 /gene="FIR1" /locus_tag="YER032W" /gene_synonym="PIP1" /coded_by="NM_001178923.3:1..2631" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0032465 regulation of cytokinesis [PMID:30455324]" /note="Protein involved in 3' mRNA processing; interacts with Ref2p; APCC(Cdh1) substrate; potential Cdc28p substrate" /db_xref="GeneID:856754" /db_xref="SGD:S000000834" ORIGIN 1 mslpvtpvks kvcstlsiqh emdhdqcrdv lcprenllai nrtnniesva iprqrssknk 61 kphehtqsqv rfsipdpnei sqdsplkivf pksgneterr mstssllmns hghlvdmhsk 121 ilvdvpkevw kfhhnrrkkc esrhrktrsd vrsntsssgk epnhsrsksl qsiivdtmnt 181 yratevetsi nentsnisqv splnlsfdrp ppltpeknly ltpesplnry hlpvpleisl 241 ppylspqnkd kkrsslvydg dgysqfqegn tssstessle qpsssysded dsipyahhdv 301 sfelnnadad kllgidenan vnlkiqrrnl knpqhikskt dreceeknte knvslkilst 361 pnklidipdl ehmksppstg lngtlkffqq fepseeptsp trqvnpesld kldmsfkfps 421 sttnnnvdkv henrnsgdtn nedflkvdts pvnqsfesrr qmlidlqksp tnnnprihkh 481 rrsrsvhnid dislnfeats tppaptsaps ipvehsnpct sieipkrspl rftsspktsd 541 ippeaqspkn gsflqeisvp siqiipdesi shtrepspsl iecpedenea fstevadhsi 601 aiisetksvp siepfkplss fnsfgqeiqn keptplnqtp tdligkqrnc vnphsipfsv 661 lssnsqssqs gsskssynse fssntaitdt tsqpsvtinr stlehnfiee krsiknlghg 721 ppsqknnysf prnkntpsnr hdldfntiye krdgkmvevi lldededvgl knndisrtrv 781 chaqkakneq qkkrlshcne ilgmcdktad dakriiyqlv nekhkfsekg qqtkpkksrv 841 lpplpfplyd ekgnslipnk yqssihndip shrklk // LOCUS NP_010950 1076 aa linear PLN 30-JUN-2025 DEFINITION Zrg8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010950 VERSION NP_010950.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178924.1 REFERENCE 1 (residues 1 to 1076) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1076) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1076) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1076) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1076) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1076) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1076) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1076) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1076) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07686. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1076 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1076 /product="Zrg8p" /calculated_mol_wt="119220" CDS 1..1076 /gene="ZRG8" /locus_tag="YER033C" /coded_by="NM_001178924.1:1..3231" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:15972461]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15972461]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:15972461]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:15972461]" /note="hypothetical protein; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency" /db_xref="GeneID:856755" /db_xref="SGD:S000000835" ORIGIN 1 mrsfikahkk stsfdespkr hsnfsgntnn ssqrssddsl dflpstpsqm nydsipppak 61 hspgfesfhr lanktsklfk ktsnsnlnsh lastpttstn qttsnsfvlq npptkntgpp 121 pplppplfps sstssfsrhd neseytaykk tspakdfnrt tdslpaikgt ithswgdskv 181 eshviilndp aspasntsea tsskqfktpi ignenltstt spsnlepair ilnknkgkqq 241 eniddaedgs skkehhvyka lalaknrnrq arihshddii nlgkasqmdm sllaaafsgn 301 stttinndqs sneqtdekil diervtttst ltssettspi nkspcfysqt lslspkirhg 361 dlqsspskvn kndsqnetln kkkvrislnr keeekvysln nnsdeysvne kethkandcn 421 dessengdgd ndhdddyddd ddddddddes efsfeyagin vrtssvkyys kpepaanvyi 481 ddlyedenfd ddmnciedde sgnegneicg lstrfeetsl ksnkvkkfnd lfnlsdddee 541 edgkdnsnng denesdnlyq krlengketf ngnhgghhdd aslgetvdnk eqflindnvk 601 kpiqkyndlf dlsdeddndd kemseaesym fsdeapsies gpanakstrg iysqsnknii 661 rdgkpnysfs lkrnnsddet ehtsaikasl tgttgstkpt vksfsdifnv ddsasdaesd 721 sgtggnnsng lvsndserqv slqsslyetk seshppnhph sqilqtpaki vitpsvsdaq 781 sqalaitddd gedddddtss ilrtpfqlid sshsqqphya spqytavlns pplppparsq 841 slkyhdlncd ldsevprpms nlffideaee deynqkskff dfdhydidei ngipedfnfs 901 dserddlnrr tlksplrggs knrevspfss vsssfrsths fngkltinqg akelapmknk 961 ieltnktvtf fnsnnwntyd cnslsrktss qmrdskyqnh nvgqnvepss vlspqhqisn 1021 gldgkcndny vispnlptti tptnsftkpt pefsndysls piqetpssvq sspkra // LOCUS NP_010951 185 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER034W [Saccharomyces cerevisiae S288C]. ACCESSION NP_010951 VERSION NP_010951.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178925.1 REFERENCE 1 (residues 1 to 185) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 185) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 185) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 185) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07687. Method: conceptual translation. FEATURES Location/Qualifiers source 1..185 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..185 /product="uncharacterized protein" /calculated_mol_wt="21059" Region 7..185 /region_name="DUF5364" /note="Family of unknown function (DUF5364); pfam17322" /db_xref="CDD:435864" CDS 1..185 /locus_tag="YER034W" /coded_by="NM_001178925.1:1..558" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856756" /db_xref="SGD:S000000836" ORIGIN 1 mdafslkkdn rkkfqdkqkl krkhatpsdr kyrllnrqke ekatteekdq dqeqpalksn 61 edryyedpvl edphsavana elnkvlkdvl knrlqqndda tavnnvankd tlkikdlkqm 121 ntdelnrwlg rqnttsaita aepeslvvpi hvqgdhdrag kkisapstdl peeletdqdf 181 ldgll // LOCUS NP_010952 145 aa linear PLN 30-JUN-2025 DEFINITION Edc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010952 VERSION NP_010952.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178926.3 REFERENCE 1 (residues 1 to 145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 145) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07688. On Jul 30, 2012 this sequence version replaced NP_010952.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..145 /product="Edc2p" /calculated_mol_wt="15940" CDS 1..145 /gene="EDC2" /locus_tag="YER035W" /coded_by="NM_001178926.3:1..438" /experiment="EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:12554867]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:12554867]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:19682251|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19682251]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0032056 positive regulation of translation in response to stress [PMID:19682251]" /note="RNA-binding protein that directly activates mRNA decapping; binds mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein increases in abundance and relocalizes to nucleolus and to nuclear foci upon DNA replication stress; EDC2 has a paralog, EDC1, that arose from the whole genome duplication" /db_xref="GeneID:856757" /db_xref="SGD:S000000837" ORIGIN 1 mgsetkhsak vkivtrespp sakehmrptk tqilvpptqs lpngkkpnfg kstkqrrepr 61 ertsktghed dkatmvtvni daflhdkapk kksckykkkk trqyqdraaa sidskphvag 121 htafagasft tdipheaalp kpsfv // LOCUS NP_010953 610 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette family ATPase ARB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010953 VERSION NP_010953.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178927.1 REFERENCE 1 (residues 1 to 610) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 610) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 610) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 610) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07689. Method: conceptual translation. FEATURES Location/Qualifiers source 1..610 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..610 /product="ATP-binding cassette family ATPase ARB1" /calculated_mol_wt="68246" Region 84..600 /region_name="Uup" /note="ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; COG0488" /db_xref="CDD:440254" CDS 1..610 /gene="ARB1" /locus_tag="YER036C" /coded_by="NM_001178927.1:1..1833" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16260602]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:16260602]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:16260602]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:16260602]" /experiment="EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:32320318]" /note="ATPase of the ATP-binding cassette (ABC) family; involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; important for disaggregation of ordered and disordered aggregates; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p; human homolog ABCF2 can complement yeast ARB1 mutant" /db_xref="GeneID:856758" /db_xref="SGD:S000000838" ORIGIN 1 mppvsaskak rdakkaerea kkaaagktir klgrkkeaaa eesevdaaar eikmmklqqd 61 kdglsdrvvt gvlssletsr diklssvsll fhgkvliqds glelnygrry gllgengcgk 121 stflkalatr eypipehidi ylldepaeps elsaldyvvt eaqhelkrie dlvektiled 181 gpesellepl yermdsldpd tfesraaiil iglgfnkkti lkktkdmsgg wkmrvalaka 241 lfvkptllll ddptahldle acvwleeylk rfdrtlvlvs hsqdflngvc tnmidmraqk 301 ltayggnyds yhktrselet nqmkqynkqq eeiqhikkfi asagtyanlv kqaksrqkil 361 dkmeadglvq pvvpdkvfsf rfpqverlpp pvlafddisf hyesnpsenl yehlnfgvdm 421 dsrialvgpn gvgkstllki mtgeltpqsg rvsrhthvkl gvysqhsqdq ldltksalef 481 vrdkysnisq dfqfwrgqlg rygltgegqt vqmatlsegq rsrvvfalla leqpnvllld 541 eptngldipt idsladaine fnggvvvvsh dfrlldkiaq difvvenkta trwdgsilqy 601 knklaknvvl // LOCUS NP_010954 321 aa linear PLN 30-JUN-2025 DEFINITION bifunctional nucleotidase/lysophosphatidic acid phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010954 VERSION NP_010954.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178928.1 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07690. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..321 /product="bifunctional nucleotidase/lysophosphatidic acid phosphatase" /calculated_mol_wt="37588" Region 54..250 /region_name="HAD_5NT" /note="haloacid dehalogenase (HAD)-like 5'-nucleotidases similar to Saccharomyces cerevisiae Phm8p and Sdt1p; cd02604" /db_xref="CDD:319791" Site order(58..62,74,101,106,165..167,204,229..230,233..234) /site_type="active" /db_xref="CDD:319791" CDS 1..321 /gene="PHM8" /locus_tag="YER037W" /coded_by="NM_001178928.1:1..966" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008252 nucleotidase activity [PMID:23670538]" /experiment="EXISTENCE:direct assay:GO:0052642 lysophosphatidic acid phosphatase activity [PMID:18234677]" /experiment="EXISTENCE:mutant phenotype:GO:0009166 nucleotide catabolic process [PMID:23670538]" /experiment="EXISTENCE:mutant phenotype:GO:0016036 cellular response to phosphate starvation [PMID:18234677]" /experiment="EXISTENCE:mutant phenotype:GO:0052642 lysophosphatidic acid phosphatase activity [PMID:18234677]" /experiment="EXISTENCE:mutant phenotype:GO:0070328 triglyceride homeostasis [PMID:26979516]" /experiment="EXISTENCE:mutant phenotype:GO:0090549 response to carbon starvation [PMID:23670538]" /note="Lysophosphatidic acid (LPA) phosphatase, nucleotidase; principle and physiological nucleotidase working on GMP, UMP and CMP; involved in LPA hydrolysis in response to phosphate starvation and ribose salvage pathway; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p; repressed by Gcn4p under normal conditions; PHM8 has a paralog, SDT1, that arose from the whole genome duplication" /db_xref="GeneID:856759" /db_xref="SGD:S000000839" ORIGIN 1 mtiakdyrti yrnqikkqir lnqehlqslt hlgsqinfev dppklpdpdp arkvfffdid 61 ntlyrkstkv qllmqqslsn ffkyelgfdd deaerliesy yqeyglsvkg liknkqiddv 121 lqyntfidds lplqdylkpd wklrellinl kkkklgkfdk lwlftnsykn haircvkilg 181 iadlfdgity chydrpieee fickpdpkff etaklqsgls sfanawfidd nesnvrsals 241 mgmghvihli edyqyeseni vtkdhknkqq fsilkdilei plimdvevyr pssiaikeme 301 eleeegeavn wsnqqinvqs s // LOCUS NP_010955 464 aa linear PLN 30-JUN-2025 DEFINITION Smc5-Smc6 complex subunit KRE29 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010955 VERSION NP_010955.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178929.3 REFERENCE 1 (residues 1 to 464) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 464) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 464) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 464) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07691. On Jul 30, 2012 this sequence version replaced NP_010955.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..464 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..464 /product="Smc5-Smc6 complex subunit KRE29" /calculated_mol_wt="53641" Region 1..454 /region_name="Nse5" /note="DNA repair proteins Nse5 and Nse6; pfam08691" /db_xref="CDD:462563" CDS 1..464 /gene="KRE29" /locus_tag="YER038C" /gene_synonym="NSE6" /coded_by="NM_001178929.3:1..1395" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:34191293]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391]" /note="Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance" /db_xref="GeneID:856760" /db_xref="SGD:S000000840" ORIGIN 1 mgsvnsspne efetvpdsqi sgfdsplipt svgsyfrddd ddekvhpnfi sdpendslns 61 deefsslens dlnlsgakae sgddfdpilk rtiiskrkap snnedeeivk tprklvnyvp 121 lkifnlgdsf ddtitttvak lqdlkkeild sprsnksivi tsntvaksel qksikfsgsi 181 peiyldvvtk etisdkykdw hfisknchye qlmdlemkdt aysflfgssr sqgkvpefvh 241 lkcpsitnll vlfgvnqekc nslkinyekk ensrydnlct ifpvnkmlkf lmyfysdddn 301 ddvrefflka ficlildrkv fnamesdhrl cfkvlelfne ahfinsyfei vdkndfflhy 361 rllqifphlq sallrrrfse kqgrtetiqq niikefneff dcknyknlly filtmygskf 421 ipfgpkcqvt eyfkdcildi snettndvei silkgilnlf skir // LOCUS NP_001288277 126 aa linear PLN 30-JUN-2025 DEFINITION Fmp49p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001288277 VERSION NP_001288277.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001301348.1 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA64607. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..126 /product="Fmp49p" /calculated_mol_wt="14217" CDS 1..126 /gene="FMP49" /locus_tag="YER038W-A" /coded_by="NM_001301348.1:1..381" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="Mitochondrial hypothetical protein; almost completely overlaps ORF HVG1/YER039C" /db_xref="GeneID:20098144" /db_xref="SGD:S000028746" ORIGIN 1 myyfsrvaar tfccciffcl ataysrpdrn prkiekkdkk ffgaskntnp anamgnlfka 61 ptieyvveev trthqpeqyd iptdmsplmt iaasesadkf tdkffvdqss imkektsskg 121 nartll // LOCUS NP_010956 249 aa linear PLN 30-JUN-2025 DEFINITION putative GDP-mannose transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_010956 VERSION NP_010956.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178930.1 REFERENCE 1 (residues 1 to 249) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 249) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 249) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 249) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07692. Method: conceptual translation. FEATURES Location/Qualifiers source 1..249 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..249 /product="putative GDP-mannose transporter" /calculated_mol_wt="27557" Region <1..232 /region_name="VRG4" /note="Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; COG5070" /db_xref="CDD:227402" CDS 1..249 /gene="HVG1" /locus_tag="YER039C" /gene_synonym="YEM9" /coded_by="NM_001178930.1:1..750" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; HVG1 has a paralog, VRG4, that arose from the whole genome duplication" /db_xref="GeneID:856761" /db_xref="SGD:S000000841" ORIGIN 1 miytsskslq ylavpiytif knltiiliay gevlffggkv tsmeltsfim mvlssvvatw 61 gdqqaiaika ssledldqel vestifvlnp gylwmftnci ssalfvlimr krirltnfkd 121 ydtmfynnvl alplllvfsf imedwstknl svnlsadsla amvisglmsv gisycsgwcv 181 rvtssttysm vgalnklpia laglvffdap knflsffsif lgflsgllya vakqkkiqqq 241 kvlaatlek // LOCUS NP_010957 72 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER039C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010957 VERSION NP_010957.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184319.1 REFERENCE 1 (residues 1 to 72) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 72) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 72) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 72) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07693. Method: conceptual translation. FEATURES Location/Qualifiers source 1..72 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..72 /product="uncharacterized protein" /calculated_mol_wt="7855" Region 10..>72 /region_name="VRG4" /note="Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; COG5070" /db_xref="CDD:227402" CDS 1..72 /locus_tag="YER039C-A" /coded_by="NM_001184319.1:1..219" /note="hypothetical protein; YER039C-A is not an essential gene" /db_xref="GeneID:856762" /db_xref="SGD:S000007226" ORIGIN 1 mskhkhewte svansgpasi lsycassilm tvtnkfvvnl dnfnmnfvml fvqslvctvt 61 lcilrivgva nf // LOCUS NP_010958 730 aa linear PLN 30-JUN-2025 DEFINITION nitrogen-responsive transcriptional regulator GLN3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010958 VERSION NP_010958.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178931.3 REFERENCE 1 (residues 1 to 730) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 730) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 730) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 730) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07694. On Jul 30, 2012 this sequence version replaced NP_010958.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..730 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..730 /product="nitrogen-responsive transcriptional regulator GLN3" /calculated_mol_wt="79252" Region 56..715 /region_name="GAT1" /note="GATA Zn-finger-containing transcription factor [Transcription]; COG5641" /db_xref="CDD:227928" CDS 1..730 /gene="GLN3" /locus_tag="YER040W" /coded_by="NM_001178931.3:1..2193" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:7608102]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:8655543]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10604478|PMID:27293098]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12140287]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:8655543]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7568152|PMID:2153652]" /note="Transcriptional activator in nitrogen catabolite repression system; localization and activity regulated by quality of nitrogen source and Ure2p; full-length protein forms prion-like aggregates when overproduced" /db_xref="GeneID:856763" /db_xref="SGD:S000000842" ORIGIN 1 mqddpenskl ydllnshldv hgrsneeprq tgdsrsqssg ntgeneedia fasglnggtf 61 dsmlealpdd lyftdfvspf taaattsvtt ktvkdttpat nhmdddiamf dslattqpid 121 iaasnqqnge iaqlwdfnvd qfnmtpsnss gsatisapns ftsdipqynh gslgnsvsks 181 slfpynssts nsninqpsin nnsntnaqsh hsfniyklqn nnssssamni tnnnnsnnsn 241 iqhpflkksd siglsssntt nsvrknslik pmsstslanf kraasvsssi snmepsgqnk 301 kpliqcfnck tfktplwrrs pegntlcnac glfqklhgtm rplslksdvi kkriskkrak 361 qtdpniaqnt psapatasts vtttnakpir srkkslqqns lsrvipeeii rdnigntnni 421 lnvnrggynf nsvpspvlmn sqsynssnan fngasnanln snnlmrhnsn tvtpnfrrss 481 rrsstssnts sssksssrsv vpilpkpspn sansqqfnmn mnlmnttnnv sagnsvassp 541 riissanfns nsplqqnlls nsfqrqgmni prrkmsrnas ysssfmaasl qqlheqqqvd 601 vnsntntnsn rqnwnssnsv stnsrssnfv sqkpnfdifn tpvdspsvsr pssrkshtsl 661 lsqqlqnses nsfisnhkfn nrlssdstsp ikyeadvsag gkisednstk gsskessaia 721 deldwlkfgi // LOCUS NP_010959 759 aa linear PLN 30-JUN-2025 DEFINITION crossover junction endodeoxyribonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_010959 VERSION NP_010959.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178932.2 REFERENCE 1 (residues 1 to 759) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 759) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 759) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 759) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07695. On Apr 26, 2011 this sequence version replaced NP_010959.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..759 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..759 /product="crossover junction endodeoxyribonuclease" /calculated_mol_wt="87233" Region 2..275 /region_name="PIN_YEN1" /note="FEN-like PIN domains of Saccharomyces cerevisiae endonuclease 1 (YEN1), Chaetomium thermophilum junction-resolving enzyme GEN1, and fungal homologs; cd09870" /db_xref="CDD:350218" Site order(2,4,7,41,47..48,118,193,195,213..214,216) /site_type="active" /db_xref="CDD:350218" Site order(124..129,167..170) /site_type="other" /note="helical arch" /db_xref="CDD:350218" Region 286..388 /region_name="H3TH_YEN1" /note="H3TH domain of Yeast Endonuclease 1, a structure-specific, divalent-metal-ion dependent, 5' nuclease; cd09906" /db_xref="CDD:188626" Site order(286..290,292..297,299..302) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:188626" Site 288 /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:188626" CDS 1..759 /gene="YEN1" /locus_tag="YER041W" /coded_by="NM_001178932.2:1..2280" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:34928393|PMID:19520826]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19520826]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:34928393]" /experiment="EXISTENCE:direct assay:GO:0008821 crossover junction DNA endonuclease activity [PMID:19020614]" /experiment="EXISTENCE:direct assay:GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity [PMID:34928393]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:20106725]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:20106725]" /experiment="EXISTENCE:mutant phenotype:GO:0008821 crossover junction DNA endonuclease activity [PMID:19020614]" /note="Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p" /db_xref="GeneID:856764" /db_xref="SGD:S000000843" ORIGIN 1 mgvsqiwefl kpylqdsrip lrkfvidfnk sqkrapriai daygwlfecg fiqnidisar 61 srsrsrsptr sprdsdidss qeyygsrsyt ttgkavinfi srlkellsln vefllvfdgv 121 mkpsfkrkfn heqnattcdd ekeyyssweq hvknhevygn ckgllapsdp efislvrkll 181 dlmnisyvia cgegeaqcvw lqvsgavdfi lsndsdtlvf ggekilknys kfyddfgpss 241 itshspsrhh dskesfvtvi dlpkinkvag kkfdrlsllf fsvllgadyn rgvkglgknk 301 slqlaqcedp nfsmefydif kdfnledlts eslrksryrl fqkrlylyck dhsvelfgrn 361 ypvllnqgsf egwpstvaim hyfhpivqpy fdeevlsdky inmagnghyr nlnfnelkyf 421 lqslnlpqis sfdkwfhdsm hemfllrefl sidesdnigk gnmriteeki mnidggkfqi 481 pcfkiryttf lpnipissqs plkrsnspsr sksptrrqmd imehpnslwl pkylipqshp 541 lviqyyetqq liqkekekkg kksnksrlpq knnldeflrk htspiksigk vgesrkeile 601 pvrkrlfvdt dedtsleeip aptrlttvde hsdndddsli fvdeitnsqs vldsspgkri 661 rdltqdeqvd vwkdvieisp ikksrttnae knppesglks rssitinarl qgtkmlppnl 721 taprlerehs svldqlvtda qdtvdrfvac dsdssstie // LOCUS NP_010960 184 aa linear PLN 30-JUN-2025 DEFINITION peptide-methionine-S-sulfoxide reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010960 VERSION NP_010960.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178933.1 REFERENCE 1 (residues 1 to 184) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 184) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 184) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 184) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07696. Method: conceptual translation. FEATURES Location/Qualifiers source 1..184 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..184 /product="peptide-methionine-S-sulfoxide reductase" /EC_number="1.8.4.11" /calculated_mol_wt="21010" Region 17..171 /region_name="msrA" /note="methionine-S-sulfoxide reductase; TIGR00401" /db_xref="CDD:129496" CDS 1..184 /gene="MXR1" /locus_tag="YER042W" /coded_by="NM_001178933.1:1..555" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20799725|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008113 peptide-methionine (S)-S-oxide reductase activity [PMID:9275166|PMID:15141092]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:11929995]" /experiment="EXISTENCE:mutant phenotype:GO:0008113 peptide-methionine (S)-S-oxide reductase activity [PMID:9275166|PMID:15141092]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:9275166|PMID:11929995]" /note="Methionine-S-sulfoxide reductase; involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan; reduced activity of human homolog implicated in Alzheimer disease" /db_xref="GeneID:856765" /db_xref="SGD:S000000844" ORIGIN 1 msslisktik ydpakdklit lacgcfwgte hmyrkylndr ivdckvgyan geeskkdsps 61 svsykrvcgg dtdfaevlqv synpkvitlr eltdfffrih dpttsnsqgp dkgtqyrsgl 121 fahsdadlke lakikeewqp kwgnkiatvi epiknfydae eyhqlyldkn pqgyacpthy 181 lrem // LOCUS NP_010961 449 aa linear PLN 30-JUN-2025 DEFINITION adenosylhomocysteinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010961 VERSION NP_010961.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178934.3 REFERENCE 1 (residues 1 to 449) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 449) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 449) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 449) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07697. On Jul 30, 2012 this sequence version replaced NP_010961.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..449 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..449 /product="adenosylhomocysteinase" /EC_number="3.13.2.1" /calculated_mol_wt="48995" Region 7..448 /region_name="AdoHcyase" /note="S-adenosyl-L-homocysteine hydrolase; pfam05221" /db_xref="CDD:461594" CDS 1..449 /gene="SAH1" /locus_tag="YER043C" /coded_by="NM_001178934.3:1..1350" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004013 adenosylhomocysteinase activity [PMID:18591246]" /experiment="EXISTENCE:mutant phenotype:GO:0006641 triglyceride metabolic process [PMID:18591246]" /experiment="EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:18591246]" /experiment="EXISTENCE:mutant phenotype:GO:0033353 S-adenosylmethionine cycle [PMID:18591246]" /note="S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels" /db_xref="GeneID:856766" /db_xref="SGD:S000000845" ORIGIN 1 msapaqnyki adislaafgr keielaehem pglmairkay gdvqplkgar iagclhmtiq 61 tavlietlva lgaevtwssc niystqdhaa aaiaasgvpv fawkgeteee ylwcieqqlf 121 afkdnkklnl ilddggdltt lvhekhpeml edcfglseet ttgvhhlyrm vkegklkvpa 181 invndsvtks kfdnlygcre slvdgikrat dvmlagkvav vagygdvgkg caaalrgmga 241 rvlvteidpi nalqaamegy qvvtmedash igqvfvtttg crdiingehf inmpedaivc 301 nighfdieid vawlkanake cinikpqvdr yllssgrhvi llangrlvnl gcatghssfv 361 mscsfsnqvl aqialfksnd ksfrekhief qktgpfevgv hvlpkildea vakfhlgnlg 421 vrltklskvq seylgipeeg pfkadhyry // LOCUS NP_010962 148 aa linear PLN 30-JUN-2025 DEFINITION Erg28p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010962 VERSION NP_010962.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178935.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07698. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..148 /product="Erg28p" /calculated_mol_wt="17004" Region 23..134 /region_name="Erg28" /note="Erg28 like protein; pfam03694" /db_xref="CDD:461015" CDS 1..148 /gene="ERG28" /locus_tag="YER044C" /gene_synonym="BUD18" /coded_by="NM_001178935.1:1..447" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12119386]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:11160377]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:10929718|PMID:29319811]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:15522820|PMID:12119386]" /note="Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p" /db_xref="GeneID:856767" /db_xref="SGD:S000000846" ORIGIN 1 mfslqdvitt tkttlaampk gylpkwllfi sivsvfnsiq tyvsgleltr kvyerkptet 61 thlsartfgt wtfiscvirf ygamylneph ifelvfmsym valfhfgsel lifrtcklgk 121 gfmgplvvst tslvwmykqr eyytgvaw // LOCUS NP_010963 408 aa linear PLN 30-JUN-2025 DEFINITION Mei4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010963 VERSION NP_010963.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180023.1 REFERENCE 1 (residues 1 to 408) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 408) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 408) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 408) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07699. Method: conceptual translation. FEATURES Location/Qualifiers source 1..408 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..408 /product="Mei4p" /calculated_mol_wt="48084" Region 1..405 /region_name="Mei4" /note="Meiosis-specific protein Mei4; pfam13971" /db_xref="CDD:464059" CDS 1..408 /gene="MEI4" /locus_tag="YER044C-A" /coded_by="NM_001180023.1:1..1227" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:17558514|PMID:16783010]" /experiment="EXISTENCE:genetic interaction:GO:0042138 meiotic DNA double-strand break formation [PMID:10224247]" /note="Meiosis-specific protein involved in forming DSBs; involved in double-strand break (DSBs) formation during meiotic recombination; required for chromosome synapsis and production of viable spores" /db_xref="GeneID:856768" /db_xref="SGD:S000001954" ORIGIN 1 msrgkledme qketsevdwi icfaliqsrn ptlwkralsr kkgdvedvga lkseknlkin 61 prenskhiyk wvapfengfl nnkslfahle piynflcqnk yksfedavgl kelqsfskdv 121 stadinnwfl prykillkil slktkeidfr glsqvfqtlq illvshyshr idsdssfkrt 181 lidvhvfnfi akflfnrill kknqndpkwl qnfydqgdgk hlcdkvdykr lcslhftliy 241 siiniqliki ktnqtfepqi lkyvsvlkli ehiliiiesl ihvlirfvsk hklicinrkk 301 aycrvylere lslkktylkn fysvisgvpe kelggllkil kivilsllet fesiewqhlk 361 pflekfpahe islqkkrkyi qaallitaer nliarfrlsr wfneteni // LOCUS NP_010964 489 aa linear PLN 30-JUN-2025 DEFINITION Aca1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010964 VERSION NP_010964.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178936.3 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07700. On Jul 30, 2012 this sequence version replaced NP_010964.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..489 /product="Aca1p" /calculated_mol_wt="54461" Region 386..442 /region_name="bZIP_ATF2" /note="Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain; cd14687" /db_xref="CDD:269835" Region 386..442 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269835" Site order(387,391,393..395,398,400..402,404..406) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269835" Site order(405,412..413,415..416,419..420,423,426..427,430, 433..434,436..437,440..441) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269835" CDS 1..489 /gene="ACA1" /locus_tag="YER045C" /coded_by="NM_001178936.3:1..1470" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10825197]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10825197]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:10825197]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10825197]" /note="ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication" /db_xref="GeneID:856769" /db_xref="SGD:S000000847" ORIGIN 1 mdykhnfats pdsfldgrqn pllytdflss nkeliykqps gpglvdsayn fhhqnslhdr 61 svqenlgpmf qpfgvdishl pitnppifqs slpafdqpvy krrisisngq isqlgedlet 121 venlyncqpp ilsskaqqnp npqqvanpsa aiypsfssne lqnvpqpheq atvipeaapq 181 tgskniyaam tpydsnikln ipavaatcdi psatpsipsg dstmnqayin mqlrlqaqmq 241 tkawknaqln vhpctpasns svssssscqn indhnienqs vhssishgvn hhtvnnscqn 301 aelnissslp yeskcpdvnl thanskpqyk datsalknni nsekdvhtap fssmhttatf 361 qikqearpqk ienntaglkd gakawkrarl lernriaask crqrkkmsql qlqrefdqis 421 kentmmkkki enyeklvqkm kkisrlhmqe ctinggnnsy qslqnkdsdv ngflkmieem 481 irssslyde // LOCUS NP_010965 143 aa linear PLN 30-JUN-2025 DEFINITION Spo73p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010965 VERSION NP_010965.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178937.1 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07701. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..143 /product="Spo73p" /calculated_mol_wt="16467" Region 108..139 /region_name="DysFC" /note="Dysferlin domain, C-terminal region; smart00694" /db_xref="CDD:128935" CDS 1..143 /gene="SPO73" /locus_tag="YER046W" /coded_by="NM_001178937.1:1..432" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:26605945|PMID:27303688]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15590821]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:27303688|PMID:26605945]" /note="Meiosis-specific protein required for prospore membrane morphogenesis; required for the proper shape of the prospore membrane (PSM) and for spore wall formation; functions cooperatively with SPO71 in PSM elongation; physically interacts with Spo71p; genetically antagonistic to SPO1, similar to SPO71; localizes to the PSM; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis; dysferlin domain-only protein" /db_xref="GeneID:856770" /db_xref="SGD:S000000848" ORIGIN 1 mgknhflkdf salpedvlie nergitllgy plfspkillp hvdppqfqrl ntengslial 61 skntisnfie lypidlster tagssssqmt kwfvlmdyke kydiddqgwc yswnfnnsrw 121 ksknglvrrr vwvrlpttsh gld // LOCUS NP_010966 897 aa linear PLN 30-JUN-2025 DEFINITION putative AAA family ATPase SAP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010966 VERSION NP_010966.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178938.1 REFERENCE 1 (residues 1 to 897) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 897) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 897) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 897) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07702. Method: conceptual translation. FEATURES Location/Qualifiers source 1..897 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..897 /product="putative AAA family ATPase SAP1" /calculated_mol_wt="100201" Region <353..543 /region_name="Herpes_BLLF1" /note="Herpes virus major outer envelope glycoprotein (BLLF1); pfam05109" /db_xref="CDD:282904" Region <539..>659 /region_name="McrB" /note="5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms]; COG1401" /db_xref="CDD:441011" Region 607..788 /region_name="RecA-like_VPS4-like" /note="ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; cd19509" /db_xref="CDD:410917" Site order(607..610,647..653) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:410917" Site order(615,619,623,627,672,676..677,705,723..724,727,731, 776,780..781,783) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:410917" Region 815..850 /region_name="AAA_lid_3" /note="AAA+ lid domain; pfam17862" /db_xref="CDD:465537" Region <847..893 /region_name="Vps4_C" /note="Vps4 C terminal oligomerization domain; pfam09336" /db_xref="CDD:462762" CDS 1..897 /gene="SAP1" /locus_tag="YER047C" /coded_by="NM_001178938.1:1..2694" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative ATPase of the AAA family; interacts with the Sin1p transcriptional repressor in the two-hybrid system" /db_xref="GeneID:856771" /db_xref="SGD:S000000849" ORIGIN 1 mdsqrshhil trltkirrrp qqpltdftel ysrianetiy ylnleekkry kealqgwkal 61 ttdvlfkqtl iehnypntqs ytkdevslqn girelyhksv mhlkrvkklv reepaprndm 121 pssktytnhs ssftrstepp pvfqmvpgrm mktlrnrnac gyktaysnps lssygnstsi 181 krgedaenir vnfvpskpls nnasrqhknp iehndpplkk etelysdkyi sepilidltn 241 deddhdvgil kghnvfdeee sdgfefdvsd yydnfsevdv eeeeeekeer rriktleaiq 301 qqmsdlsvts stssnksvss senvpgsciq slpttapalp slppppllnv drasstgalk 361 phsletsttm dsskirnpqi sklmknnhvp ylkgtkstpt litkstptfi trsksntkpi 421 iksnasspts sltvpnsviq kpktaamaak rvlnskkvas npalnttkks hpilksktak 481 vpnssskkts shpsrpvsns kpyshgasqn kkpsknqtts msktnrkipa qkkigspkie 541 dvgtedateh atslneqree peidkkvlre iledeiidsl qgvdrqaakq ifaeivvhgd 601 evhwddiagl esakyslkea vvypflrpdl frglrepvrg mllfgppgtg ktmlaravat 661 eshstffsis assltskylg eseklvralf aiakklspsi ifvdeidsim gsrnnenene 721 ssrriknefl vqwsslssaa agsnksntnn sdtngdeddt rvlvlaatnl pwsideaarr 781 rfvrrqyipl pedqtrhvqf kkllshqkht ltesdfdelv kitegysgsd itslakdaam 841 gplrdlgdkl leteremirp iglvdfknsl vyikpsvsqd glvkyekwas qfgssgs // LOCUS NP_010967 391 aa linear PLN 30-JUN-2025 DEFINITION Caj1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010967 VERSION NP_010967.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178939.3 REFERENCE 1 (residues 1 to 391) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 391) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 391) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 391) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07703. On Jul 30, 2012 this sequence version replaced NP_010967.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..391 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..391 /product="Caj1p" /calculated_mol_wt="44724" Region 7..>96 /region_name="PRK10767" /note="chaperone protein DnaJ; Provisional" /db_xref="CDD:236757" Region 176..376 /region_name="DnaJ-X" /note="X-domain of DnaJ-containing; pfam14308" /db_xref="CDD:433858" CDS 1..391 /gene="CAJ1" /locus_tag="YER048C" /coded_by="NM_001178939.3:1..1176" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:32777224]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:32777224]" /experiment="EXISTENCE:direct assay:GO:1901981 phosphatidylinositol phosphate binding [PMID:39289920]" /note="Nuclear type II J heat shock protein of the E. coli dnaJ family; binds to numerous phosphatidylinositol phosphates; overexpression stabilizes amino acid permeases; binds non-native substrates for presentation to Ssa3p, and may function during protein translocation, assembly and disassembly; localizes to the cytosol and plasma membrane, while a GFP fusion protein is nuclear; contains an N-terminal J-domain, a leucine zipper-like motif, and a putative C-terminal DNAJ-X domain" /db_xref="GeneID:856772" /db_xref="SGD:S000000850" ORIGIN 1 mvketeyydi lgikpeatpt eikkayrrka methpdkhpd dpdaqakfqa vgeayqvlsd 61 pglrskydqf gkedavpqqg fedaseyfta ifggdgfkdw igefslfkel neatemfgke 121 deegtaatet ekadestdgg mvkhdtnkae slkkdklske qreklmemek krredmmkqv 181 delaeklnek isryliavks nnleeftrkl dqeiedlkle sfglellyll arvyktkann 241 fimskktygi skiftgtrdn arsvksaynl lstgleaqka mekmsevntd eldqyerakf 301 estmagkalg vmwamskfel erklkdvcnk ilndkkvpsk eriakakaml fiahkfasar 361 rspeeaeear vfeelilgeq ekehkkhtva r // LOCUS NP_010968 94 aa linear PLN 30-JUN-2025 DEFINITION Isd11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010968 VERSION NP_010968.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184330.1 REFERENCE 1 (residues 1 to 94) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 94) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 94) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 94) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07704. Method: conceptual translation. FEATURES Location/Qualifiers source 1..94 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..94 /product="Isd11p" /calculated_mol_wt="11135" Region 11..79 /region_name="Complex1_LYR_LYRM4" /note="LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins; cd20264" /db_xref="CDD:380759" Site order(12..13,38..39,42..43,46..47,55,58,65,69) /site_type="other" /note="phosphopantetheine binding site [chemical binding]" /db_xref="CDD:380759" Site order(13,16..17,20..21,29..31,33..34,37..38,40..41,44,47, 68,71..72,75) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:380759" CDS 1..94 /gene="ISD11" /locus_tag="YER048W-A" /coded_by="NM_001184330.1:1..285" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:16341090|PMID:16341089]" /experiment="EXISTENCE:direct assay:GO:0031071 cysteine desulfurase activity [PMID:24045011]" /experiment="EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:24045011]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:16341090|PMID:16341089]" /experiment="EXISTENCE:physical interaction:GO:0016226 iron-sulfur cluster assembly [PMID:16341090]" /experiment="EXISTENCE:physical interaction:GO:1990221 L-cysteine desulfurase complex [PMID:24045011]" /note="Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family" /db_xref="GeneID:856774" /db_xref="SGD:S000007237" ORIGIN 1 mpgftaptrr qvlslykefi knanqfnnyn freyflsktr ttfrknmnqq dpkvlmnlfk 61 eakndlgvlk rqsvisqmyt fdrlvveplq grkh // LOCUS NP_010969 644 aa linear PLN 30-JUN-2025 DEFINITION oxidative DNA demethylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010969 VERSION NP_010969.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178940.1 REFERENCE 1 (residues 1 to 644) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 644) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 644) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 644) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07705. Method: conceptual translation. FEATURES Location/Qualifiers source 1..644 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..644 /product="oxidative DNA demethylase" /calculated_mol_wt="73911" Region 145..246 /region_name="2OG-FeII_Oxy_4" /note="2OG-Fe(II) oxygenase superfamily; pfam13661" /db_xref="CDD:433386" Region 333..638 /region_name="Ofd1_CTDD" /note="Oxoglutarate and iron-dependent oxygenase degradation C-term; pfam10637" /db_xref="CDD:402326" CDS 1..644 /gene="TPA1" /locus_tag="YER049W" /coded_by="NM_001178940.1:1..1935" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:20040577]" /experiment="EXISTENCE:direct assay:GO:0018188 peptidyl-proline di-hydroxylation [PMID:31320474|PMID:24550462]" /experiment="EXISTENCE:direct assay:GO:0031543 peptidyl-proline dioxygenase activity [PMID:31320474|PMID:24550462]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:16809762]" /experiment="EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:16809762|PMID:24550462|PMID:20630870]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:24550462]" /experiment="EXISTENCE:mutant phenotype:GO:0008198 ferrous iron binding [PMID:25381260]" /note="Prolyl hydroxylase; catalyzes oxygen-dependent dihydroxylation of Rps23a/b, a 40S ribosomal decoding center subunit; influences translational termination and regulates translational accuracy; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; disputed role as a oxidative dealkylase repairing DNA methyl-base lesions; poly(rA)-binding protein affecting poly(A) tail length and mRNA stability; Fe(II)/2-oxoglutarate-dependent dioxygenase family member similar to human prolyl 4-hydroxylase OGFOD1" /db_xref="GeneID:856775" /db_xref="SGD:S000000851" ORIGIN 1 mkrktaevkg ekernskqis leedkikgmf npkiwdktfq dglkkeieds qpynwgtihe 61 lvnddllrav rkeieteihf tkketdiyrv nqsgdlanls gldwddlsrl pnlfklrqil 121 yskqyrdffg yvtkagklsg sktdmsinty tkgchllthd dvigsrrisf ilylpdpdrk 181 wkshyggglr lfpsilpnvp hsdpsaklvp qfnqiaffkv lpgfsfhdve evkvdkhrls 241 iqgwyhipqv geegyipgee eawvrnntst laqiesnvle dfefpkdern ilsfhevkhf 301 ekmlkgdaga ktdntpkesm tsvisdsvkl seaeftylsq yispehlssk gieklqkqfv 361 ensslqiesf lnddksellk kvikqkeleq ecpyhskdvk apwktaipph karylyidgk 421 eyrnfqtead ilealnnndl pnfqftkdai kiisdasgns rennfdaela lidlavfhks 481 tifkkylall tslcpvseqi lirrfrpgmd ftlatkcrfn ellksnpdii davlegtlcl 541 tpsagwesge lggyelymmd ddednkqylk edvedasvyr addsgdsvli ndppawntfn 601 lvlrdesvle fvkyvswsak ssrwdvkmkw dvkscdedgq edea // LOCUS NP_010970 138 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein bS18m RSM18 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010970 VERSION NP_010970.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178941.3 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07706. On Jul 30, 2012 this sequence version replaced NP_010970.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..138 /product="mitochondrial 37S ribosomal protein bS18m RSM18" /calculated_mol_wt="15704" Region 93..138 /region_name="Ribosomal_S18" /note="Ribosomal protein S18; pfam01084" /db_xref="CDD:460054" CDS 1..138 /gene="RSM18" /locus_tag="YER050C" /gene_synonym="bS18m" /coded_by="NM_001178941.3:1..417" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S18 ribosomal protein" /db_xref="GeneID:856776" /db_xref="SGD:S000000852" ORIGIN 1 mqpiikgavs stfkralynf gikekksvni emgrtqqtkk idqslskklp kgtiydpfdf 61 smgrihldrk yqanknsnrn dimksganpl efyarprils ryvtstgriq hrditglsak 121 nqrrlskair rcqaiglm // LOCUS NP_010971 492 aa linear PLN 30-JUN-2025 DEFINITION [Histone H3]-lysine-36 demethylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010971 VERSION NP_010971.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178942.1 REFERENCE 1 (residues 1 to 492) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 492) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 492) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 492) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07707. Method: conceptual translation. FEATURES Location/Qualifiers source 1..492 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..492 /product="[Histone H3]-lysine-36 demethylase" /EC_number="1.14.11.27" /calculated_mol_wt="56399" Region 6..69 /region_name="PHD" /note="PHD zinc finger; smart00249" /db_xref="CDD:214584" Site order(20..25,28,30,33) /site_type="other" /note="histone H3 binding site [polypeptide binding]" /db_xref="CDD:276992" Region <278..320 /region_name="JmjC" /note="A domain family that is part of the cupin metalloenzyme superfamily; smart00558" /db_xref="CDD:214721" CDS 1..492 /gene="JHD1" /locus_tag="YER051W" /gene_synonym="KDM2" /coded_by="NM_001178942.1:1..1479" /experiment="EXISTENCE:direct assay:GO:0051864 histone H3K36 demethylase activity [PMID:16362057]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:17142463]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:17525156]" /experiment="EXISTENCE:mutant phenotype:GO:0051864 histone H3K36 demethylase activity [PMID:17369256]" /note="JmjC domain family histone demethylase specific for H3-K36; similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe" /db_xref="GeneID:856777" /db_xref="SGD:S000000853" ORIGIN 1 mqdpnicqhc qlkdnpgali wvkcdscpqw vhvkcvplkr ihysnltsse vlsypnsakq 61 iksyrcpnhk egeyltayal itqkgkrqrn kenpedshin krynfrkkkl ldyialnege 121 skrdkmnhph kesfmksfek wkngsniina adfaekfdni dvpykiidpl nsgvyvpnvg 181 tdngcltvny itemigedyh vdvmdvqsqm nenwnlgswn eyftntepdr rdrirnvisl 241 evsnieglel erptavrqnd lvdkiwsfng hlekvngeka eendpkpkvt kyilmsvkda 301 ytdfhldfag tsvyynvisg qkkfllfppt qsnidkyiew slkedqnsvf lgdiledgia 361 meldagdlfm ipagyihavy tpvdslvfgg nfltirdlet hlkiveiekl tkvprrftfp 421 kfdqvmgklc eylaldknki tsdvsdgdll srttncaiqs lhayvikpev kykplnftsk 481 khlakaladl is // LOCUS NP_010972 527 aa linear PLN 30-JUN-2025 DEFINITION aspartate kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010972 VERSION NP_010972.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178943.1 REFERENCE 1 (residues 1 to 527) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 527) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 527) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 527) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07708. Method: conceptual translation. FEATURES Location/Qualifiers source 1..527 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..527 /product="aspartate kinase" /EC_number="2.7.2.4" /calculated_mol_wt="57979" Region 13..324 /region_name="AAK_AK-Hom3" /note="Amino Acid Kinase Superfamily (AAK), AK-Hom3; this CD includes the N-terminal catalytic domain of the aspartokinase HOM3, a monofunctional class enzyme found in Saccharomyces cerevisiae and other related AK domains. Aspartokinase, the first enzyme in the...; cd04247" /db_xref="CDD:239780" Site order(18,279,292) /site_type="active" /note="putative catalytic residues [active]" /db_xref="CDD:239780" Site order(18,20..22,254..255,258..259) /site_type="other" /note="putative nucleotide binding site [chemical binding]" /db_xref="CDD:239780" Site order(54..55,60,147) /site_type="other" /note="putative aspartate binding site [chemical binding]" /db_xref="CDD:239780" Region 362..435 /region_name="ACT_AK-Hom3_1" /note="CT domains located C-terminal to the catalytic domain of the aspartokinase (AK) HOM3, a monofunctional class enzyme found in Saccharomyces cerevisiae, and other related ACT domains; cd04934" /db_xref="CDD:153206" Site order(399,406) /site_type="active" /note="putative threonine allosteric regulatory residues [active]" /db_xref="CDD:153206" Region 437..502 /region_name="ACT_AK-Hom3_2" /note="ACT domains located C-terminal to the catalytic domain of the aspartokinase (AK) HOM3; cd04919" /db_xref="CDD:153191" Site order(452,472) /site_type="active" /note="putative threonine allosteric regulatory residues [active]" /db_xref="CDD:153191" CDS 1..527 /gene="HOM3" /locus_tag="YER052C" /gene_synonym="BOR1; SIL4; THR3" /coded_by="NM_001178943.1:1..1584" /experiment="EXISTENCE:direct assay:GO:0004072 aspartate kinase activity [PMID:18626862]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009088 threonine biosynthetic process [PMID:18626862]" /experiment="EXISTENCE:mutant phenotype:GO:0004072 aspartate kinase activity [PMID:18626862]" /experiment="EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:4380684]" /experiment="EXISTENCE:mutant phenotype:GO:0009088 threonine biosynthetic process [PMID:18626862|PMID:4380684]" /experiment="EXISTENCE:mutant phenotype:GO:0009090 homoserine biosynthetic process [PMID:4380684]" /note="Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; subject to allosteric feedback inhibition by threonine; expression regulated by Gcn4p and the general control of amino acid synthesis" /db_xref="GeneID:856778" /db_xref="SGD:S000000854" ORIGIN 1 mpmdfqptss hsnwvvqkfg gtsvgkfpvq ivddivkhys kpdgpnnnva vvcsarssyt 61 kaegttsrll kccdlasqes efqdiievir qdhidnadrf ilnpalqakl vddtnkelel 121 vkkylnaskv lgevssrtvd lvmscgekls clfmtalcnd rgckakyvdl shivpsdfsa 181 saldnsfytf lvqalkekla pfvsakeriv pvftgffglv ptgllngvgr gytdlcaali 241 avavnadelq vwkevdgift adprkvpear lldsvtpeea seltyygsev ihpftmeqvi 301 rakipirikn vqnplgngti iypdnvakkg estpphppen lsssfyekrk rgataittkn 361 difvinihsn kktlshgfla qiftildkyk lvvdlistse vhvsmalpip dadslkslrq 421 aeeklrilgs vditkklsiv slvgkhmkqy igiagtmftt laeeginiem isqganeini 481 scvinesdsi kalqcihakl lsertntsnq fehaiderle qlkrlgi // LOCUS NP_010973 300 aa linear PLN 30-JUN-2025 DEFINITION Cu/Pi carrier [Saccharomyces cerevisiae S288C]. ACCESSION NP_010973 VERSION NP_010973.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178944.3 REFERENCE 1 (residues 1 to 300) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 300) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 300) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 300) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07709. On Jul 30, 2012 this sequence version replaced NP_010973.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..300 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..300 /product="Cu/Pi carrier" /calculated_mol_wt="33397" Region 23..102 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 103..190 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 214..293 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..300 /gene="PIC2" /locus_tag="YER053C" /coded_by="NM_001178944.3:1..903" /experiment="EXISTENCE:direct assay:GO:0005315 phosphate transmembrane transporter activity [PMID:14756774]" /experiment="EXISTENCE:direct assay:GO:0005375 copper ion transmembrane transporter activity [PMID:23846699]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14756774|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0035434 copper ion transmembrane transport [PMID:23846699]" /experiment="EXISTENCE:direct assay:GO:0035435 phosphate ion transmembrane transport [PMID:14756774]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:23846699]" /note="Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature" /db_xref="GeneID:856779" /db_xref="SGD:S000000855" ORIGIN 1 mesnkqprki qlytkefyat ctlggiiacg pthssitpld lvkcrlqvnp klytsnlqgf 61 rkiianegwk kvytgfgatf vgyslqgagk yggyeyfkhl ysswlspgvt vylmasatae 121 fladimlcpf eaikvkqqtt mppfcnnvvd gwkkmyaesg gmkafykgiv plwcrqipyt 181 mckftsfeki vqkiysvlpk kkeemnalqq isvsfvggyl agilcaavsh padvmvskin 241 serkanesms vaskriyqki gftglwnglm vrivmigtlt sfqwliydsf kayvglpttg // LOCUS NP_061492 37 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER053C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_061492 VERSION NP_061492.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184444.1 REFERENCE 1 (residues 1 to 37) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 37) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 37) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 37) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 37) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 37) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 37) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 37) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 37) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07710. Method: conceptual translation. FEATURES Location/Qualifiers source 1..37 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..37 /product="uncharacterized protein" /calculated_mol_wt="4328" CDS 1..37 /locus_tag="YER053C-A" /coded_by="NM_001184444.1:1..114" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856780" /db_xref="SGD:S000007523" ORIGIN 1 mqdleiflsi fafifvfyfg ahrtvmnrnk sdvpylq // LOCUS NP_010974 548 aa linear PLN 30-JUN-2025 DEFINITION Gip2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010974 VERSION NP_010974.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178945.1 REFERENCE 1 (residues 1 to 548) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 548) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 548) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 548) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07711. Method: conceptual translation. FEATURES Location/Qualifiers source 1..548 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..548 /product="Gip2p" /calculated_mol_wt="62188" Region 429..533 /region_name="CBM_21" /note="Carbohydrate/starch-binding module (family 21); pfam03370" /db_xref="CDD:427265" CDS 1..548 /gene="GIP2" /locus_tag="YER054C" /coded_by="NM_001178945.1:1..1647" /experiment="EXISTENCE:direct assay:GO:0019888 protein phosphatase regulator activity [PMID:8754819]" /experiment="EXISTENCE:mutant phenotype:GO:0005977 glycogen metabolic process [PMID:11973298]" /experiment="EXISTENCE:physical interaction:GO:0000164 protein phosphatase type 1 complex [PMID:8754819]" /note="Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from the whole genome duplication" /db_xref="GeneID:856781" /db_xref="SGD:S000000856" ORIGIN 1 myikaeqkpq qferknekld rnknqqlpdl etdfkgyrvn sdlynkerdg steetlnslk 61 flhkpqrvtq mranrfpeee vqrntdlnkr ifsagndenv dnesgwskia aaknhtsves 121 lngstrppfk ielpplspks tvpksfqaey peakspgndm nfeydeeili pfappvykks 181 gellksslkr rskslpttpg irsgngvqar dgspmlirsk svhfdqaapv kyfaedespi 241 nvnkteqhdn clsfkhkpvn lmvdpeeetk mlssgletts idddlttvap kgfahpakis 301 npnngkgtnn tklrkskrfq nllknrtdmp psksnkkfvn gggaheisdr nsknyhvvgl 361 ysknfpilsn knpkslklni finlsqnkkv flqelslyih rdnnyfsnss sfynipnshn 421 gndcngvakg ynagctrlia grilvknify dkrvvvrytw dswrttheve cvyisdgdgi 481 lpgtnmdifh fiiddvskvd prgklefcih ystrndyere eywdnnngnn ykvdvvmdgf 541 ndpfaaaa // LOCUS NP_010975 297 aa linear PLN 30-JUN-2025 DEFINITION ATP phosphoribosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010975 VERSION NP_010975.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178946.3 REFERENCE 1 (residues 1 to 297) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 297) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 297) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 297) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07712. On Jul 30, 2012 this sequence version replaced NP_010975.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..297 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..297 /product="ATP phosphoribosyltransferase" /EC_number="2.4.2.17" /calculated_mol_wt="32135" Region 10..219 /region_name="PBP2_HisGL2" /note="The catalytic domain of hexameric long form HisGL2; contains the type 2 periplasmic binding protein fold; cd13592" /db_xref="CDD:270310" Site order(155,157,170..172,174..177) /site_type="other" /note="chemical substrate binding site [chemical binding]" /db_xref="CDD:270310" Region 206..296 /region_name="HisG_C-term" /note="ATP phosphoribosyltransferase, C-terminal domain; TIGR03455" /db_xref="CDD:274587" CDS 1..297 /gene="HIS1" /locus_tag="YER055C" /coded_by="NM_001178946.3:1..894" /experiment="EXISTENCE:mutant phenotype:GO:0000105 L-histidine biosynthetic process [PMID:14190241]" /experiment="EXISTENCE:mutant phenotype:GO:0003879 ATP phosphoribosyltransferase activity [PMID:14190241]" /note="ATP phosphoribosyltransferase; a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control" /db_xref="GeneID:856782" /db_xref="SGD:S000000857" ORIGIN 1 mdlvnhltdr llfaipkkgr lysksvsiln gaditfhrsq rldialstsl pvalvflpaa 61 diptfvgegk cdlgitgvdq vresnvdvdl aidlqfgnck lqvqvpvnge ykkpeqligk 121 tivtsfvkla ekyfadlegt tvekmttrik fvsgsveasc algigdaivd lvesgetmra 181 aglvdiatvl stsayliesk npksdkslia tiksriegvm taqrfvsciy napedklpel 241 lkvtpgrrap tiskiddegw vavssmierk tkgvvldelk rlgasdimvf eisncrv // LOCUS NP_010976 533 aa linear PLN 30-JUN-2025 DEFINITION purine-cytosine permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_010976 VERSION NP_010976.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178947.1 REFERENCE 1 (residues 1 to 533) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 533) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 533) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 533) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07713. Method: conceptual translation. FEATURES Location/Qualifiers source 1..533 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..533 /product="purine-cytosine permease" /calculated_mol_wt="58070" Region 76..494 /region_name="Transp_cyt_pur" /note="Permease for cytosine/purines, uracil, thiamine, allantoin; pfam02133" /db_xref="CDD:251109" Site order(96,99,369,372..373) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271377" Site order(100,177,181,277..278,280,374,378) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:271377" CDS 1..533 /gene="FCY2" /locus_tag="YER056C" /gene_synonym="BRA7" /coded_by="NM_001178947.1:1..1602" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8267570|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0015205 nucleobase transmembrane transporter activity [PMID:9092500]" /experiment="EXISTENCE:direct assay:GO:0015212 cytidine transmembrane transporter activity [PMID:10501935]" /experiment="EXISTENCE:direct assay:GO:0015856 cytosine transport [PMID:9092500]" /experiment="EXISTENCE:direct assay:GO:0015861 cytidine transport [PMID:10501935]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0072530 purine-containing compound transmembrane transport [PMID:9092500]" /experiment="EXISTENCE:mutant phenotype:GO:0015212 cytidine transmembrane transporter activity [PMID:10501935]" /experiment="EXISTENCE:mutant phenotype:GO:0015861 cytidine transport [PMID:10501935]" /note="Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress" /db_xref="GeneID:856783" /db_xref="SGD:S000000858" ORIGIN 1 mleegnnvye iqdlekrspv igsslenekk vaasetftat seddqqyive sseatklswf 61 hkffaslnae tkgvepvted ektddsilna asmwfsanmv iasyalgalg pmvfglnfgq 121 svlviiffni mglifvaffs vfgaelglrq milsrylvgn vtarifslin viacvgwgiv 181 ntsvsaqlln mvnegsghvc piwagcliii ggtvlvtffg ysvihayekw swvpnfavfl 241 viiaqlsrsg kfkggewvgg attagsvlsf gssifgfaag wttyaadytv ympkstnkyk 301 iffslvagla fplfftmilg aasamaalnd ptwkayydkn amggviyail vpnslngfgq 361 fccvllalst iannipnmyt valsaqalwa plakiprvvw tmagnaatlg isipatyyfd 421 gfmenfmdsi gyylaiyiai scsehffyrr sfsayniddw dnwehlpigi agtaalivga 481 fgvalgmcqt ywvgeigrli gkyggdigfe lgaswafiiy nilrplelky fgr // LOCUS NP_010977 121 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL34 RPL34A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010977 VERSION NP_010977.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180036.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07714. On Aug 9, 2000 this sequence version replaced NP_010977.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..121 /product="60S ribosomal protein eL34 RPL34A" /calculated_mol_wt="13508" Region 1..>108 /region_name="PTZ00074" /note="60S ribosomal protein L34; Provisional" /db_xref="CDD:185429" CDS 1..121 /gene="RPL34A" /locus_tag="YER056C-A" /coded_by="NM_001180036.1:1..366" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:23874617]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:23874617]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23874617]" /experiment="EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:23874617]" /note="Ribosomal 60S subunit protein L34A; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34A has a paralog, RPL34B, that arose from the whole genome duplication" /db_xref="GeneID:856784" /db_xref="SGD:S000002135" ORIGIN 1 maqrvtfrrr npyntrsnki kvvktpggil raqhvkklat rpkcgdcgsa lqgistlrpr 61 qyatvskthk tvsrayggsr cancvkerii raflieeqki vkkvvkeqte aakksekkak 121 k // LOCUS NP_010978 129 aa linear PLN 30-JUN-2025 DEFINITION putative isoleucine biosynthesis protein HMF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010978 VERSION NP_010978.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178948.3 REFERENCE 1 (residues 1 to 129) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 129) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 129) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 129) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07715. On Jul 30, 2012 this sequence version replaced NP_010978.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..129 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..129 /product="putative isoleucine biosynthesis protein HMF1" /calculated_mol_wt="13775" Region 24..127 /region_name="TIGR00004" /note="reactive intermediate/imine deaminase" /db_xref="CDD:129116" Site order(24,26,29,31,33..34,73,75..76,78,80,91,94,103..110, 120,122,124) /site_type="other" /note="homotrimer interaction site [polypeptide binding]" /db_xref="CDD:100004" Site order(87,91,105,120) /site_type="active" /note="putative active site [active]" /db_xref="CDD:100004" CDS 1..129 /gene="HMF1" /locus_tag="YER057C" /gene_synonym="HIG1" /coded_by="NM_001178948.3:1..390" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11442631]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11442631]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11003673]" /note="Member of the p14.5 protein family; functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro; HMF1 has a paralog, MMF1, that arose from the whole genome duplication" /db_xref="GeneID:856785" /db_xref="SGD:S000000859" ORIGIN 1 mvttltpvic esapaaaasy shamkvnnli flsgqipvtp dnklvegsia dkaeqviqni 61 knvleasnss ldrvvkvnif ladinhfaef nsvyakyfnt hkparscvav aalplgvdme 121 meaiaaerd // LOCUS NP_010979 107 aa linear PLN 30-JUN-2025 DEFINITION Pet117p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010979 VERSION NP_010979.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178949.1 REFERENCE 1 (residues 1 to 107) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 107) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 107) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 107) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07716. Method: conceptual translation. FEATURES Location/Qualifiers source 1..107 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..107 /product="Pet117p" /calculated_mol_wt="12150" Region 5..88 /region_name="PET117" /note="PET assembly of cytochrome c oxidase, mitochondrial; pfam15786" /db_xref="CDD:434937" CDS 1..107 /gene="PET117" /locus_tag="YER058W" /coded_by="NM_001178949.1:1..324" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:27998984|PMID:8381337]" /note="Assembly factor that couples heme a synthesis to complex IV assembly; regulates the oligomerization state of the Cox15p heme a synthase, and couples this to the assembly of the cytochrome C oxidase complex (complex IV)" /db_xref="GeneID:856786" /db_xref="SGD:S000000860" ORIGIN 1 msraskitfa asclitaatv vgvhyvqeme retlhqgpik dakrveekrl rktngvasld 61 ptkerkryfn mseheeqkel rkkyetmqpl sgevvtkdge vvkeskk // LOCUS NP_010980 420 aa linear PLN 30-JUN-2025 DEFINITION Pcl6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010980 VERSION NP_010980.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178950.1 REFERENCE 1 (residues 1 to 420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 420) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07717. Method: conceptual translation. FEATURES Location/Qualifiers source 1..420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..420 /product="Pcl6p" /calculated_mol_wt="46876" Region 170..388 /region_name="Cyclin" /note="pfam08613" /db_xref="CDD:400780" Site order(247,249,350..356,358..360,374,377..378,381..382, 385..391) /site_type="other" /note="CDK interface [polypeptide binding]" /db_xref="CDD:410261" CDS 1..420 /gene="PCL6" /locus_tag="YER059W" /coded_by="NM_001178950.1:1..1263" /experiment="EXISTENCE:genetic interaction:GO:0005979 regulation of glycogen biosynthetic process [PMID:11602261]" /experiment="EXISTENCE:genetic interaction:GO:0005981 regulation of glycogen catabolic process [PMID:11602261]" /note="Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding; PCL6 has a paralog, PCL7, that arose from the whole genome duplication" /db_xref="GeneID:856787" /db_xref="SGD:S000000861" ORIGIN 1 msikgdspss tnassspkst ysiqsddkan lgsgnvdirt dnsqqdsnnr rdivvvtrva 61 seetlesqss tssmgirpes sfnyedasnq arvemnnrvh gsnmntinky ypvrfpknne 121 rqlsdtnnln ekvqgthtvq sstqedkild gdtsnsqvtp slniaefptd kllkmltall 181 tkiiksndrt aatnpsltqe iengrclals dnekkylspv lgfrgkhvpq igldqyfqri 241 qkycpttndv flsllvyfdr iskrcnsvtt tpktntakhe spsnessldk anrgadkmsa 301 cnsnennend dsddentgvq rdsrahpqmf vmdshnihrl iiagitvstk flsdffysns 361 rysrvggisl qelnhlelqf lvlcdfelli svnelqryad llyrfwnnak aqsqalvtgm // LOCUS NP_010981 528 aa linear PLN 30-JUN-2025 DEFINITION purine-cytosine permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_010981 VERSION NP_010981.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178951.3 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07718. On Jul 30, 2012 this sequence version replaced NP_010981.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..528 /product="purine-cytosine permease" /calculated_mol_wt="57919" Region 73..489 /region_name="Transp_cyt_pur" /note="Permease for cytosine/purines, uracil, thiamine, allantoin; pfam02133" /db_xref="CDD:251109" Site order(93,96,364,367..368) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271377" Site order(97,174,178,272..273,275,369,373) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:271377" CDS 1..528 /gene="FCY21" /locus_tag="YER060W" /coded_by="NM_001178951.3:1..1587" /experiment="EXISTENCE:mutant phenotype:GO:0015205 nucleobase transmembrane transporter activity [PMID:16845689]" /experiment="EXISTENCE:mutant phenotype:GO:0015856 cytosine transport [PMID:16845689]" /note="Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function" /db_xref="GeneID:856788" /db_xref="SGD:S000000862" ORIGIN 1 mpqthemsln gtqylkyelk dlesrahdak tpstnefydd veshgteelv eaklsflnri 61 aaglsaetkg iepitedekt ddsilnaasm wfsanmvlpa yaigalgpmv fdlnfgqsvf 121 viiffnllgl vsvaffsvfg aelglrqmil srylvgniaa rifsfinfia cigwgivntv 181 assqvlnmvn pghqcplwag civiigatvi vtffgygvih ayekwawvpn favflviiar 241 larskkfvlg ewtsgpttag nvlsfgstvy gfaagwttya adytvymprk tnkykiffsl 301 vvglatplyf tmilgaavam aaigdpawkt yydensiggl tfavlvpnsv hgfgqfccvl 361 lslstiannv pnmytialsv qatweplakv prviwtllgn aaalgiaipa cyyfstfmny 421 fmdsigyyla iyiaiacseh fiyrrsfsay nvddwdswer lpigiagtaa livgafgval 481 gmcqtywvge isrligdygg digfelglsw afivyniarp felkyfgr // LOCUS NP_010982 530 aa linear PLN 30-JUN-2025 DEFINITION purine-cytosine permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_010982 VERSION NP_010982.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180858.1 REFERENCE 1 (residues 1 to 530) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 530) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 530) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 530) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07719. Method: conceptual translation. FEATURES Location/Qualifiers source 1..530 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..530 /product="purine-cytosine permease" /calculated_mol_wt="57196" Region 73..491 /region_name="Transp_cyt_pur" /note="Permease for cytosine/purines, uracil, thiamine, allantoin; pfam02133" /db_xref="CDD:251109" Site order(93,96,366,369..370) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271377" Site order(97,174,178,274..275,277,371,375) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:271377" CDS 1..530 /gene="FCY22" /locus_tag="YER060W-A" /coded_by="NM_001180858.1:1..1593" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015205 nucleobase transmembrane transporter activity [PMID:16845689]" /experiment="EXISTENCE:mutant phenotype:GO:0015856 cytosine transport [PMID:16845689]" /note="Putative purine-cytosine permease; very similar to Fcy2p but cannot substitute for its function" /db_xref="GeneID:856789" /db_xref="SGD:S000002958" ORIGIN 1 mpeklamsmv dikdagselr dlesgaldtk ssaadvyyeg velhrtnefi dnkpsffnri 61 aaalnaetkg iepvtedekn ddsilnaati wfsanmviva ysvgalgplv fglnfgqsvl 121 viiffnilgl ipvalfslfg velglrqmil srylagnita rffslvnvia cvgwcvlnis 181 vsaqllnmvn egsghncpiw agcliiaggt vlvtffgysv vhayekwswv pnfaaflvii 241 aqlsrsgkfk ggewvggatt aggvlsfgss vfgsaagwat yaadytvymp kttskykiff 301 svvaglafpl fftmilgaac gmaalndptw ksyydknamg gviyailvpn slngfgqfcc 361 vllalstvan nvpgmytval saqalwapla kiprvvwtma gnaatlgisi patyyfdgfm 421 enfmdsigyy laiyiaiacs ehfiyrrsfs ayniddwdnw ehlpigiagt aaliagafgv 481 algmcqtywv geisrligey ggdigfelgg swafiiyniv rplelkyfgr // LOCUS NP_010983 442 aa linear PLN 30-JUN-2025 DEFINITION fatty acid synthase CEM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010983 VERSION NP_010983.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178952.2 REFERENCE 1 (residues 1 to 442) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 442) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 442) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 442) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07720. On Apr 26, 2011 this sequence version replaced NP_010983.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..442 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..442 /product="fatty acid synthase CEM1" /EC_number="2.3.1.41" /calculated_mol_wt="47424" Region 3..436 /region_name="KAS_I_II" /note="Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; cd00834" /db_xref="CDD:238430" Site order(132,139..140,144,146..147,158,164,168,172,178,180, 182..184,196,199..200,203,224..225,228..229,282..286,300, 428,430) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238430" Site order(187,322,362) /site_type="active" /db_xref="CDD:238430" CDS 1..442 /gene="CEM1" /locus_tag="YER061C" /coded_by="NM_001178952.2:1..1329" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]" /note="Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant" /db_xref="GeneID:856790" /db_xref="SGD:S000000863" ORIGIN 1 msrrvvitgl gcvtplgrsl seswgnllss kngltpitsl pnynedyklr eksipstitv 61 gkipenfqne nsainkllft sqderrtssf iklalrttye alhnagllnp nditintslc 121 nldhfgclig sgigsiqdiy qtslqfhndn krinpyfvpk iltnmaagnv sikfnlrgls 181 hsvstacatg nnsigdafnf irlgmqdicv agasetslhp lslagfirak sittngisrp 241 fdtqrsgfvl gegcgmivme slehaqkrna niiselvgyg lssdachits ppadgngakr 301 aiemalkmar leptdvdyvn ahatstllgd kaeclavasa llpgrskskp lyissnkgai 361 ghllgaagav esifticslk ddkmphtlnl dnvltlenne adklhfirdk pivganpkya 421 lcnsfgfggv ntsllfkkwe gs // LOCUS NP_010984 250 aa linear PLN 30-JUN-2025 DEFINITION glycerol-1-phosphatase GPP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010984 VERSION NP_010984.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178953.3 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07721. On Jul 30, 2012 this sequence version replaced NP_010984.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..250 /product="glycerol-1-phosphatase GPP2" /EC_number="3.1.3.21" /calculated_mol_wt="27683" Region 14..227 /region_name="HAD_ScGPP-like" /note="subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p); cd07527" /db_xref="CDD:319829" Site order(18..22,54..55,115..117,147,178..179,182..183) /site_type="active" /db_xref="CDD:319829" CDS 1..250 /gene="GPP2" /locus_tag="YER062C" /gene_synonym="HOR2" /coded_by="NM_001178953.3:1..753" /experiment="EXISTENCE:direct assay:GO:0000121 sn-glycerol 1-phosphatase activity [PMID:8662716]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005975 carbohydrate metabolic process [PMID:8662716]" /experiment="EXISTENCE:direct assay:GO:0006970 response to osmotic stress [PMID:8662716]" /experiment="EXISTENCE:mutant phenotype:GO:0006114 glycerol biosynthetic process [PMID:11058591]" /note="DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication" /db_xref="GeneID:856791" /db_xref="SGD:S000000864" ORIGIN 1 mglttkplsl kvnaalfdvd gtiiisqpai aafwrdfgkd kpyfdaehvi qvshgwrtfd 61 aiakfapdfa neeyvnklea eipvkygeks ievpgavklc nalnalpkek wavatsgtrd 121 maqkwfehlg irrpkyfita ndvkqgkphp epylkgrngl gypineqdps kskvvvfeda 181 pagiaagkaa gckiigiatt fdldflkekg cdiivknhes irvggynaet devefifddy 241 lyakddllkw // LOCUS NP_010985 218 aa linear PLN 30-JUN-2025 DEFINITION Tho1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010985 VERSION NP_010985.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178954.1 REFERENCE 1 (residues 1 to 218) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 218) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 218) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 218) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07722. Method: conceptual translation. FEATURES Location/Qualifiers source 1..218 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..218 /product="Tho1p" /calculated_mol_wt="24006" Region 4..38 /region_name="SAP" /note="SAP domain; pfam02037" /db_xref="CDD:460424" Region <39..109 /region_name="LGT" /note="Prolipoprotein diacylglyceryl transferase; cl00478" /db_xref="CDD:469786" Region 127..164 /region_name="Tho1_MOS11_C" /note="Tho1/MOS11 C-terminal domain; pfam18592" /db_xref="CDD:465813" CDS 1..218 /gene="THO1" /locus_tag="YER063W" /coded_by="NM_001178954.1:1..657" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16738307]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:16738307]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:16738307]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:9707445]" /experiment="EXISTENCE:genetic interaction:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:16738307]" /experiment="EXISTENCE:mutant phenotype:GO:0022618 protein-RNA complex assembly [PMID:16738307]" /note="Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation" /db_xref="GeneID:856792" /db_xref="SGD:S000000865" ORIGIN 1 madyssltvv qlkdlltkrn lsvgglknel vqrlikddee skgesevspq eqnqeqgsep 61 aaieepasqn itekkevsse pketnepkee nkdvqkpsdg psataseneq aaastaapal 121 speeikakal dllnkklhra nkfgqdqadi dslqrqinrv ekfgvdlnsk laeelglvsr 181 knepesgnng kfknrnknan nrsrvsknrr gnrsgyrr // LOCUS NP_010986 505 aa linear PLN 30-JUN-2025 DEFINITION Vhr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010986 VERSION NP_010986.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178955.1 REFERENCE 1 (residues 1 to 505) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 505) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 505) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 505) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07723. Method: conceptual translation. FEATURES Location/Qualifiers source 1..505 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..505 /product="Vhr2p" /calculated_mol_wt="56507" Region 22..103 /region_name="Vhr1" /note="Transcription factor Vhr1; pfam04001" /db_xref="CDD:397898" CDS 1..505 /gene="VHR2" /locus_tag="YER064C" /coded_by="NM_001178955.1:1..1518" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11342098]" /note="Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:856793" /db_xref="SGD:S000000866" ORIGIN 1 middtenski hlegshktgk ytgygtthki raqlnfndek kwkkfssrrl elidsfglsq 61 hkaseqddni rqiatilrse feypdtfsae feklvtaavq svrrnrkrsk kklldskkki 121 argkvqkipl sppsssnmgs csasnasssd eeasvkeepa ehalpslnti tsqkllpypn 181 grtlppvptq vrsllkknas llrdpsapya hggdeklqkf diedqplese qeydfiaksi 241 iveivnnaip lpeqiqrdkf irpnltkkkg cqskvvisnn lrklilskih nsrtclemsk 301 dernldsfan letlgknslm asislvvens fshlpsstkq ylterlssie fltilsqrlf 361 mpatrqlfad lsqekiqvrv lnlilgslvk dygfdaslap ineiiyhmtl hqyplvcsnk 421 qsnpmrphst sevlsahsst kdastpgkee prvtrsstsa dstiitlpsi evpntydddr 481 lkmlsaislq ienstfskpf stisk // LOCUS NP_010987 557 aa linear PLN 30-JUN-2025 DEFINITION isocitrate lyase 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010987 VERSION NP_010987.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178956.3 REFERENCE 1 (residues 1 to 557) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 557) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 557) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 557) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07724. On Jul 30, 2012 this sequence version replaced NP_010987.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..557 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..557 /product="isocitrate lyase 1" /EC_number="4.1.3.1" /EC_number="4.1.3.30" /calculated_mol_wt="62278" Region 22..550 /region_name="ICL" /note="Isocitrate lyase family; pfam00463" /db_xref="CDD:278869" CDS 1..557 /gene="ICL1" /locus_tag="YER065C" /coded_by="NM_001178956.3:1..1674" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9370278|PMID:8870676]" /experiment="EXISTENCE:mutant phenotype:GO:0004451 isocitrate lyase activity [PMID:1551398]" /experiment="EXISTENCE:mutant phenotype:GO:0006097 glyoxylate cycle [PMID:8878673]" /note="Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose" /db_xref="GeneID:856794" /db_xref="SGD:S000000867" ORIGIN 1 mpipvgntkn dfaalqakld adaaeiekww sdsrwsktkr nysardiavr rgtfppieyp 61 ssvmarklfk vlekhhnegt vsktfgaldp vqisqmakyl dtiyisgwqc sstastsnep 121 gpdladypmd tvpnkvehlf kaqlfhdrkq learskaksq eeldemgapi dyltpivada 181 daghggltav fkltkmfier gaagihmedq tstnkkcghm agrcvipvqe hvnrlvtirm 241 cadimhsdli vvartdseaa tlisstidtr dhyfivgatn pniepfaevl ndaimsgasg 301 qeladieqkw crdaglklfh eavideiers alsnkqelik kftskvgplt etshreakkl 361 akeilgheif fdwelprvre glyryrggtq csimrarafa pyadlvwmes nypdfqqake 421 faegvkekfp dqwlaynlsp sfnwpkamsv deqhtfiqrl gdlgyiwqfi tlaglhtnal 481 avhnfsrdfa kdgmkayaqn vqqremddgv dvlkhqkwsg aeyidgllkl aqggvsataa 541 mgtgvtedqf kengvkk // LOCUS NP_010988 185 aa linear PLN 30-JUN-2025 DEFINITION Rrt13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010988 VERSION NP_010988.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178957.1 REFERENCE 1 (residues 1 to 185) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 185) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 185) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 185) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07725. Method: conceptual translation. FEATURES Location/Qualifiers source 1..185 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..185 /product="Rrt13p" /calculated_mol_wt="20555" Region <2..176 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 15..71 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 76..110 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 118..150 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..185 /gene="RRT13" /locus_tag="YER066W" /coded_by="NM_001178957.1:1..558" /note="hypothetical protein; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription" /db_xref="GeneID:856796" /db_xref="SGD:S000000868" ORIGIN 1 mkclyilsgh tdriystiyd herkrcisas mdttiriwdl enirnngecs yatnsaspca 61 kilgamytlr ghralvgllg lsdkflvsas vdgsircwda ntyflkhffd htqlntital 121 hvsdevlvsg segllniydl nsgllvrsdt lsgadnvwnv sfkdntlvaa verdkrnlle 181 ildfs // LOCUS NP_010990 161 aa linear PLN 30-JUN-2025 DEFINITION Rgi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010990 VERSION NP_010990.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178958.1 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07726. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..161 /product="Rgi1p" /calculated_mol_wt="18858" Region <21..157 /region_name="RGI1" /note="Respiratory growth induced protein 1; pfam10843" /db_xref="CDD:371266" CDS 1..161 /gene="RGI1" /locus_tag="YER067W" /coded_by="NM_001178958.1:1..486" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:20567505]" /experiment="EXISTENCE:mutant phenotype:GO:0006112 energy reserve metabolic process [PMID:20567505]" /note="Protein involved in energy metabolism under respiratory conditions; abundance is increased upon intracellular iron depletion or in response to DNA replication stress; suppresses pro-apoptotic effect of expressing human BAX in yeast cells; RGI1 has a paralog, RGI2, that arose from the whole genome duplication" /db_xref="GeneID:856797" /db_xref="SGD:S000000869" ORIGIN 1 mtkkdkkevk vqtvttedge tvkvfedlqg fetfianete dddfdhlhck lnyyppfvlh 61 eshedpekis daanshskkf vrhlhqhiek hllkdikqav rkpelkfhek skeetfdkit 121 whygeeteyh grpfkidvqv vcthedamvf vdykthpvga n // LOCUS NP_010991 587 aa linear PLN 30-JUN-2025 DEFINITION CCR4-NOT core ubiquitin-protein ligase subunit MOT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010991 VERSION NP_010991.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178959.3 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07727. On Jul 30, 2012 this sequence version replaced NP_010991.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..587 /product="CCR4-NOT core ubiquitin-protein ligase subunit MOT2" /EC_number="2.3.2.27" /calculated_mol_wt="65223" Region 9..560 /region_name="MOT2" /note="Transcriptional repressor [Transcription]; COG5175" /db_xref="CDD:227502" CDS 1..587 /gene="MOT2" /locus_tag="YER068W" /gene_synonym="NOT4; SIG1" /coded_by="NM_001178959.3:1..1764" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:19346402]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:30609991]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:16926149]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:30609991]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:30609991|PMID:19346402|PMID:16926149]" /experiment="EXISTENCE:direct assay:GO:0070534 protein K63-linked ubiquitination [PMID:30609991]" /experiment="EXISTENCE:direct assay:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:30609991|PMID:31219035]" /experiment="EXISTENCE:genetic interaction:GO:0010498 proteasomal protein catabolic process [PMID:24261871]" /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:19346402]" /experiment="EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15706350]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:11404327]" /experiment="EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:10490603]" /note="Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication" /db_xref="GeneID:856799" /db_xref="SGD:S000000870" ORIGIN 1 mmnphvqenl qaihnalsnf dtsflsedee dycplciepm ditdknffpc pcgyqicqfc 61 ynnirqnpel ngrcpacrrk yddenvryvt lspeelkmer aklarkeker khrekerken 121 eytnrkhlsg trviqknlvy vvginppvpy eevaptlkse kyfgqygkin kivvnrktph 181 snnttsehyh hhspgygvyi tfgskddaar ciaqvdgtym dgrlikaayg ttkycssylr 241 glpcpnpncm flhepgeead sfnkrelhnk qqaqqqsggt aftrsgihnn iststagsnt 301 nllsenftgt pspaamraql hhdshtnagt pvltpapvpa gsnpwgvtqs atpvtsinls 361 knsssinlpt lndslghhtt pttentitst ttttntnats hshgskkkqs laaeeykdpy 421 dalgnavdfl darlhslsny qkrpisiksn iideetykky pslfswdkie askksdntla 481 nklveilaik pidytasvvq flqsvnvgvn dnititdntk tptqpirlqt vsqqiqppln 541 vstpppgifg pqhkvpiqqq qmgdtssrns sdllnqling rkiiagn // LOCUS NP_010992 863 aa linear PLN 30-JUN-2025 DEFINITION bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_010992 VERSION NP_010992.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178960.1 REFERENCE 1 (residues 1 to 863) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 863) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 863) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 863) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 863) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 863) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 863) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 863) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 863) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07728. Method: conceptual translation. FEATURES Location/Qualifiers source 1..863 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..863 /product="bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase" /EC_number="1.2.1.38" /EC_number="2.7.2.8" /calculated_mol_wt="94739" Region 100..348 /region_name="AAK_NAGK-fArgBP" /note="N-Acetyl-L-glutamate kinase (NAGK) of the fungal arginine-biosynthetic pathway (fArgBP). The nuclear-encoded, mitochondrial polyprotein precursor with an N-terminal NAGK (ArgB) domain (this CD), a central DUF619 domain, and a C-terminal reductase domain...; cd04252" /db_xref="CDD:239785" Site order(103,106..107,136,249,270..272,276,301,303,305..306, 309) /site_type="other" /note="putative nucleotide binding site [chemical binding]" /db_xref="CDD:239785" Site order(135..137,157..158,247..250) /site_type="other" /note="putative N-acetyl-L-glutamate binding site [chemical binding]" /db_xref="CDD:239785" Region 333..499 /region_name="NAT" /note="N-acetyltransferase, of N-acetylglutamate synthase; pfam04768" /db_xref="CDD:398437" Region 542..856 /region_name="argC" /note="N-acetyl-gamma-glutamyl-phosphate reductase, common form; TIGR01850" /db_xref="CDD:273832" CDS 1..863 /gene="ARG56" /locus_tag="YER069W" /coded_by="NM_001178960.1:1..2592" /experiment="EXISTENCE:direct assay:GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity [PMID:1851947]" /experiment="EXISTENCE:direct assay:GO:0003991 acetylglutamate kinase activity [PMID:1851947]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:1851947]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:15486299]" /note="Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine" /db_xref="GeneID:856800" /db_xref="SGD:S000000871" ORIGIN 1 mpsasllvst krlnaskfqk fvsslnksti agfasvplra ppsvaftrkk vgyskryvss 61 tngfsatrst viqllnnist kreveqylky ftsvsqqqfa vikvggaiis dnlhelascl 121 aflyhvglyp ivlhgtgpqv ngrleaqgie pdyidgirit dehtmavvrk cfleqnlklv 181 taleqlgvra rpitsgvfta dyldkdkykl vgniksvtke pieasikaga lpiltslaet 241 asgqmlnvna dvaagelarv feplkivyln ekggiingst gekisminld eeyddlmkqs 301 wvkygtklki reikelldyl prsssvaiin vqdlqkelft dsgagtmirr gyklvkrssi 361 gefpsadalr kalqrdagis sgkesvasyl rylensdfvs yadepleava ivkkdtnvpt 421 ldkfvcsdaa wlnnvtdnvf nvlrrdfpal qwvvsendan iawhfdksqg sylkggkvlf 481 wygiddinti selvenfvks cdtastlnss assgvfankk sarsystrst prpegvntnp 541 grvaligarg ytgknlvsli nghpylevah vssrelkgqk lqdytkseii yeslqiqdir 601 kleeqnavdf wvmalpnkvc epfvetiqsv hgkskiidls adhrfvsesd wayglpelnd 661 rakianaaki anpgcyatgs qltispltky inglptvfgv sgysgagtkp spkndpkfln 721 nnlipyalsd hihereisar ighnvafmph vgqwfqgisl tvsipikkgs lsideirkly 781 rnfyedeklv hviddiplvk diegthgvvi ggfklndaed rvvvcatidn llkgaatqcl 841 qninlamgyg eyagipenki igv // LOCUS NP_010993 888 aa linear PLN 30-JUN-2025 DEFINITION ribonucleotide-diphosphate reductase subunit RNR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010993 VERSION NP_010993.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178961.1 REFERENCE 1 (residues 1 to 888) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 888) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 888) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 888) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07729. Method: conceptual translation. FEATURES Location/Qualifiers source 1..888 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..888 /product="ribonucleotide-diphosphate reductase subunit RNR1" /EC_number="1.17.4.1" /calculated_mol_wt="99431" Region 1..758 /region_name="PLN02437" /note="ribonucleoside--diphosphate reductase large subunit" /db_xref="CDD:178056" Site order(202..203,217..218,247,426,428,430,445,606..611) /site_type="active" /db_xref="CDD:153088" Site order(214,228..229,232,235..236,239..240,243,258,270, 274..275,277..278,281..282,285..289) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153088" Site order(218,426,428,430,443,741..742) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:153088" Site order(226..228,231,243,256,270,275) /site_type="active" /note="effector binding site [active]" /db_xref="CDD:153088" Site order(336,339..340,342..343,386,390,397,720..722,724..725, 729..730,732..733) /site_type="active" /note="R2 peptide binding site [active]" /db_xref="CDD:153088" CDS 1..888 /gene="RNR1" /locus_tag="YER070W" /gene_synonym="CRT7; RIR1; SDS12" /coded_by="NM_001178961.1:1..2667" /experiment="EXISTENCE:direct assay:GO:0000166 nucleotide binding [PMID:16537479]" /experiment="EXISTENCE:direct assay:GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [PMID:10716984|PMID:11893751|PMID:10535923]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:12732713|PMID:9315670]" /experiment="EXISTENCE:direct assay:GO:0005971 ribonucleoside-diphosphate reductase complex [PMID:10716984]" /experiment="EXISTENCE:direct assay:GO:0009263 deoxyribonucleotide biosynthetic process [PMID:5459124|PMID:10535923]" /experiment="EXISTENCE:mutant phenotype:GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [PMID:8552025]" /note="Major isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; relative distribution to the nucleus increases upon DNA replication stress; RNR1 has a paralog, RNR3, that arose from the whole genome duplication" /db_xref="GeneID:856801" /db_xref="SGD:S000000872" ORIGIN 1 myvykrdgrk epvqfdkita risrlcygld pkhidavkvt qriisgvyeg vttieldnla 61 aetcaymttv hpdyatlaar iaisnlhkqt tkqfskvved lyryvnaatg kpapmisddv 121 ynivmenkdk lnsaivydrd fqysyfgfkt lersyllrin gqvaerpqhl imrvalgihg 181 rdieaalety nlmslkyfth asptlfnagt pkpqmsscfl vamkedsieg iydtlkecal 241 isktaggigl hihnirstgs yiagtngtsn glipmirvfn ntaryvdqgg nkrpgafaly 301 lepwhadifd fidirknhgk eeirardlfp alwipdlfmk rveengtwtl fsptsapgls 361 dcygdefeal ytryekegrg ktikaqklwy sileaqtetg tpfvvykdac nrksnqknlg 421 vikssnlcce iveysapdet avcnlasval pafietsedg ktstynfkkl heiakvvtrn 481 lnrvidrnyy pveearksnm rhrpialgvq gladtfmllr lpfdseearl lniqifetiy 541 hasmeascel aqkdgpyetf qgspasqgil qfdmwdqkpy gmwdwdtlrk dimkhgvrns 601 ltmapmptas tsqilgynec fepvtsnmys rrvlsgefqv vnpyllrdlv dlgiwdegmk 661 qylitqngsi qglpnvpqel kdlyktvwei sqktiinmaa drsvyidqsh slnlflrapt 721 mgkltsmhfy gwkkglktgm yylrtqaasa aiqftidqki adqatenvad isnlkrpsym 781 pssasyaasd fvpaavtana tipsldssse asreaspapt gshsltkgma elnvqeskve 841 vpevpaptkn eekaapivdd eetefdiyns kviacaidnp eacemcsg // LOCUS NP_010994 126 aa linear PLN 30-JUN-2025 DEFINITION Tda2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010994 VERSION NP_010994.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178962.3 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07730. On Jul 30, 2012 this sequence version replaced NP_010994.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..126 /product="Tda2p" /calculated_mol_wt="14367" Region 5..124 /region_name="DLC-like_TDA2" /note="dynein light chain (DLC)-like domain found in topoisomerase I damage affected protein 2 (TDA2) and similar proteins; cd21457" /db_xref="CDD:412005" Site order(5,7,47..48,51..52,55..56,59,66..78,87..96,122,124) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:412005" CDS 1..126 /gene="TDA2" /locus_tag="YER071C" /coded_by="NM_001178962.3:1..381" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:28706108|PMID:29467252]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:29467252]" /experiment="EXISTENCE:physical interaction:GO:0030837 negative regulation of actin filament polymerization [PMID:29467252]" /experiment="EXISTENCE:physical interaction:GO:0110131 Aim21-Tda2 complex [PMID:28706108|PMID:29467252]" /note="Subunit of a complex that associates with actin filaments; forms a complex with Aim21p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; TcTex1-type dynein light chain family member; null mutant is sensitive to expression of the top1-T722A allele" /db_xref="GeneID:856802" /db_xref="SGD:S000000873" ORIGIN 1 msmqieikdg rsdnsplper klvtliqesy dslkddnein lstestsnll iklvleklek 61 hsslykyias vttlniegln eenanfslkn digasweskk dgifnykled knnnecylit 121 ilwlhk // LOCUS NP_010995 129 aa linear PLN 30-JUN-2025 DEFINITION Vtc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_010995 VERSION NP_010995.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178963.1 REFERENCE 1 (residues 1 to 129) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 129) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 129) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 129) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07731. Method: conceptual translation. FEATURES Location/Qualifiers source 1..129 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..129 /product="Vtc1p" /calculated_mol_wt="14240" Region 1..124 /region_name="VTC1" /note="Vacuolar transporter chaperone [Posttranslational modification, protein turnover, chaperones]; COG5264" /db_xref="CDD:227589" CDS 1..129 /gene="VTC1" /locus_tag="YER072W" /gene_synonym="NRF1; PHM4" /coded_by="NM_001178963.1:1..390" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:12584253]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:27831485]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:11102525|PMID:19390046]" /experiment="EXISTENCE:mutant phenotype:GO:0006799 polyphosphate biosynthetic process [PMID:27252384]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:27252384|PMID:11823419]" /experiment="EXISTENCE:physical interaction:GO:0033254 vacuolar transporter chaperone complex [PMID:11823419]" /note="Regulatory subunit of vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; also binds mRNA; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856803" /db_xref="SGD:S000000874" ORIGIN 1 mssapllqrt pgkkialptr vepkvffane rtflswlnft vmlgglgvgl lnfgdkigrv 61 saglftfvam gtmiyalvty hwraaairrr gsgpyddrlg ptllcffllv aviinfilrl 121 kyndantkl // LOCUS NP_010996 520 aa linear PLN 30-JUN-2025 DEFINITION aldehyde dehydrogenase (NAD(P)(+)) ALD5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010996 VERSION NP_010996.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178964.2 REFERENCE 1 (residues 1 to 520) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 520) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 520) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 520) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07732. On Apr 26, 2011 this sequence version replaced NP_010996.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..520 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..520 /product="aldehyde dehydrogenase (NAD(P)(+)) ALD5" /EC_number="1.2.1.4" /calculated_mol_wt="56562" Region 41..513 /region_name="ALDH_F1-2_Ald2-like" /note="ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; cd07091" /db_xref="CDD:143410" Site order(186..187,189..190,213,216,245..246,250..251,264..267, 270,273..274,288..290,322,419,421,447,485) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:143410" Site order(190,288,319,322) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:143410" CDS 1..520 /gene="ALD5" /locus_tag="YER073W" /coded_by="NM_001178964.2:1..1563" /experiment="EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:9473035]" /experiment="EXISTENCE:direct assay:GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity [PMID:9473035]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10585550|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0019413 acetate biosynthetic process [PMID:15256563]" /note="Mitochondrial aldehyde dehydrogenase; involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed" /db_xref="GeneID:856804" /db_xref="SGD:S000000875" ORIGIN 1 mlsrtraaap nsriftrsll rlysqaplrv pitlpngfty eqptglfing efvaskqkkt 61 fdvinpsnee kittvykame ddvdeavaaa kkafetkwsi vepevrakal fnladlvekh 121 qetlaaiesm dngkslfcar gdvalvskyl rscggwadki ygnvidtgkn hftysikepl 181 gvcgqiipwn fpllmwswki gpalatgntv vlkpaettpl salfasqlcq eagipagvvn 241 ilpgsgrvvg erlsahpdvk kiaftgstat grhimkvaad tvkkvtlelg gkspnivfad 301 adldkavkni afgifynsge vccagsriyi qdtvyeevlq klkdyteslk vgdpfdeevf 361 qgaqtsdkql hkildyvdva ksegarlvtg garhgskgyf vkptvfadvk edmrivkeev 421 fgpivtvskf stvdeviama ndsqyglaag ihtndinkav dvskrvkagt vwintynnfh 481 qnvpfggfgq sgigremgea alsnytqtks vriaidkpir // LOCUS NP_010997 135 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS24 RPS24A [Saccharomyces cerevisiae S288C]. ACCESSION NP_010997 VERSION NP_010997.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178965.3 REFERENCE 1 (residues 1 to 135) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 135) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 135) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 135) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07733. On Jul 30, 2012 this sequence version replaced NP_010997.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..135 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..135 /product="40S ribosomal protein eS24 RPS24A" /calculated_mol_wt="15198" Region 1..123 /region_name="PTZ00071" /note="40S ribosomal protein S24; Provisional" /db_xref="CDD:240256" CDS 1..135 /gene="RPS24A" /locus_tag="YER074W" /gene_synonym="RPS24EA" /coded_by="NM_001178965.3:1..408" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication" /db_xref="GeneID:856805" /db_xref="SGD:S000000876" ORIGIN 1 msdavtirtr kvisnpllar kqfvvdvlhp nranvskdel reklaevyka ekdavsvfgf 61 rtqfgggksv gfglvynsva eakkfeptyr lvryglaekv ekasrqqrkq kknrdkkifg 121 tgkrlakkva rrnad // LOCUS NP_219496 85 aa linear PLN 30-JUN-2025 DEFINITION Yos1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_219496 VERSION NP_219496.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184512.1 REFERENCE 1 (residues 1 to 85) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 85) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 85) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 85) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07734. On Feb 2, 2004 this sequence version replaced NP_219496.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..85 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..85 /product="Yos1p" /calculated_mol_wt="9305" Region 6..85 /region_name="Yos1" /note="Yos1-like; pfam08571" /db_xref="CDD:462523" CDS 1..85 /gene="YOS1" /locus_tag="YER074W-A" /coded_by="NM_001184512.1:1..258" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:15659647]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:15659647]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:15659647]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:15659647]" /experiment="EXISTENCE:physical interaction:GO:0000139 Golgi membrane [PMID:15659647]" /experiment="EXISTENCE:physical interaction:GO:0005789 endoplasmic reticulum membrane [PMID:15659647]" /experiment="EXISTENCE:physical interaction:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:15659647]" /note="Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p" /db_xref="GeneID:856806" /db_xref="SGD:S000007651" ORIGIN 1 mvlfglgrlf yvilllinav avlseerflr riglgrsnde tpvfgqdqnt tkskvvqlig 61 avqtllripl iginilvivy elllg // LOCUS NP_010998 928 aa linear PLN 30-JUN-2025 DEFINITION tyrosine protein phosphatase PTP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_010998 VERSION NP_010998.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178966.2 REFERENCE 1 (residues 1 to 928) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 928) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 928) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 928) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07735. On Apr 26, 2011 this sequence version replaced NP_010998.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..928 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..928 /product="tyrosine protein phosphatase PTP3" /EC_number="3.1.3.48" /calculated_mol_wt="105093" Region 97..231 /region_name="DSP_MapKP" /note="N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by...; cd01446" /db_xref="CDD:238723" Site 144..146 /site_type="active" /note="putative substrate binding residues [active]" /db_xref="CDD:238723" Region 571..873 /region_name="PTP_fungal" /note="fungal protein tyrosine phosphatases; cd18533" /db_xref="CDD:350509" CDS 1..928 /gene="PTP3" /locus_tag="YER075C" /coded_by="NM_001178966.2:1..2787" /experiment="EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:9224718]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17952059]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10523653|PMID:17952059]" /experiment="EXISTENCE:direct assay:GO:1903138 negative regulation of cell integrity MAPK cascade [PMID:9224718]" /experiment="EXISTENCE:genetic interaction:GO:0043937 regulation of sporulation [PMID:10679022]" /experiment="EXISTENCE:genetic interaction:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:10523653]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:10817757]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:10817757]" /experiment="EXISTENCE:mutant phenotype:GO:0071507 pheromone response MAPK cascade [PMID:9224718]" /experiment="EXISTENCE:mutant phenotype:GO:0140311 protein sequestering activity [PMID:10817757]" /note="Phosphotyrosine-specific protein phosphatase; major role in the pheromone adaptive response through dephosphorylation of the Fus3p MAPK with a minor role by Ptp2p and Msg5p; minor role in the inactivation of Hog1p MAPK during osmolarity sensing with major role by Ptp2p; dephosphorylates and regulates the localization of Hog1p; minor role in the cell wall integrity pathway through tyrosine dephosphorylation of the MAPK Slt2p while Ptp2p plays a major role; localizes to the cytoplasm" /db_xref="GeneID:856807" /db_xref="SGD:S000000877" ORIGIN 1 mkdsvdcpsi lptdrtsvls etstlvgsss hvysrhapmn syhnsmnsni yhspkasspl 61 vsyktsspvl lkratapvlp sfkpkeqryn kpqgcslita velgkiietl pdekvllldv 121 rpftehaksi itnsihvclp stllrrknft fsklldnltp seqsvlkskl aidnlriiiy 181 dstanqtess vslpcygias kliefdtnvk ktvsilmcgf pqfkilfpdh intntfnsdc 241 issaepkspk tnlmnslhnt aphmtattpl sspqmnlklk vpddsrsdhs nfssspsprn 301 vlsdspmsss spisalfkfq lpapqtninq mfkfsqneei mgletylsav nikeeherwy 361 nndsakkslq nfqfpknqns lekdtnkdkl gfqiryenls knyekevids vipewfqhlm 421 sipkielvsq fqkldflekr rlnhsvsfrk kensfilekp ssypeqltst ssstimppkf 481 pdvnkvqkrs hsqpiftqys kyksmlsles dsdsesddvi issgvelgak nrykdifpye 541 hsrvilkkgl qsskgikhsh stsdggildn yinanylslp rfsveqnssf qttttttrrv 601 ryiatqapmp stvhdfytci lnngvplvls ltndfengie kcyrywqegn yngihvklle 661 kkilkmpstt smrkntmgtq nsslysagvq gnssnystdn dndndnnnnn nnnsniavta 721 aacddddddd ddailirkil ltyhdqekpy ellqiqvknw pdlgtllnpi silqainvkn 781 hiidtlfarn yyqndqlpti lvhcsagcgr tgtlctidsi lsnfemfeml qkefvklkyp 841 aklfdpiswt inifrkqris mvqninqfif iydcllfyfr lrldditert dgdgsnkdni 901 slsalieqie kleilqtfvd dklkelpq // LOCUS NP_010999 302 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER076C [Saccharomyces cerevisiae S288C]. ACCESSION NP_010999 VERSION NP_010999.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178967.3 REFERENCE 1 (residues 1 to 302) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 302) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 302) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 302) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07736. On Jul 30, 2012 this sequence version replaced NP_010999.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..302 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..302 /product="uncharacterized protein" /calculated_mol_wt="33335" Region <218..275 /region_name="DUF6736" /note="Family of unknown function (DUF6736); pfam20521" /db_xref="CDD:466670" CDS 1..302 /locus_tag="YER076C" /coded_by="NM_001178967.3:1..909" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization" /db_xref="GeneID:856809" /db_xref="SGD:S000000878" ORIGIN 1 mtsgyytvsf fyailllcac traeiyltgg esqglpsgfw qmdddlaiap vsmvefyqti 61 gltangtvpe sfnkrdatey pniisnittq aanftqhslv eqlqndvtai sisnainvav 121 dgsvetpadl qynrnqetge stlcrakfyg vevrtwsrly nravssttlt tnlnsyiaqw 181 vawavhgsgd kkfcgsqeft niffdgqegw slfvktwstn sscditaseg nltcavrvsv 241 ssmhnhgkta fcvtyshgds wraelrvvan dawshyypws idcpevdknn maindcfdqa 301 qg // LOCUS NP_011000 688 aa linear PLN 30-JUN-2025 DEFINITION Mrx1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011000 VERSION NP_011000.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178968.1 REFERENCE 1 (residues 1 to 688) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 688) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 688) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 688) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07737. Method: conceptual translation. FEATURES Location/Qualifiers source 1..688 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..688 /product="Mrx1p" /calculated_mol_wt="79417" Region 196..246 /region_name="PPR_2" /note="PPR repeat family; pfam13041" /db_xref="CDD:463778" CDS 1..688 /gene="MRX1" /locus_tag="YER077C" /coded_by="NM_001178968.1:1..2067" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239]" /note="Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport" /db_xref="GeneID:856810" /db_xref="SGD:S000000879" ORIGIN 1 mglkitkgql rtkdlnqsss kssqssrigv dtciftrmlp rintainlte hllrrsfhsl 61 tnlqktqvke rlhelerhgf ilnktskqle rinskkrrql kklqktaypk dqafhilrkf 121 hkinnealad tklgptsqsd lkflsltkdk rlfytilgvn geqlrdskli andvqkflkr 181 gqlekavfla rlakkkgvvg mnlimkyyie vvqsqqsavd ifnwrkkwgv pidqhsitil 241 fnglskqenl vskkygelvl ktidslcdkn elteieynta laalinctde tlvfkllnkk 301 cpglkkdsit ytlmirsctr iadekrfmvv lndlmnkipd ycvdskllfe ycevicsqks 361 pkiekqgmgl walceyfqfd ktifkkyltq sdfptlvpls hwninkpfpl nkhvvglfmn 421 yclknkeydl ameifktlea qnnqmldqsi yhkymetvit trpitcgdec ldiyervass 481 aqisitrrtl ilvynafqrq slkavinkda snaeatlhki rgfidsveat yssklngkvy 541 rfnswkflfp ivknlnmndk vstvelksil deylksllng efgkefkasi edkrfvtleg 601 irlvkvlter iklpsldsee iaslkgterk kflarrhllr lkqilledla diegnsrrkg 661 dsentstsee rimedlaeli letsydkf // LOCUS NP_011001 511 aa linear PLN 30-JUN-2025 DEFINITION aminopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011001 VERSION NP_011001.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178969.1 REFERENCE 1 (residues 1 to 511) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 511) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 511) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 511) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07738. Method: conceptual translation. FEATURES Location/Qualifiers source 1..511 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..511 /product="aminopeptidase" /EC_number="3.4.11.26" /calculated_mol_wt="57859" Region 70..192 /region_name="AMP_N" /note="Aminopeptidase P, N-terminal domain; pfam05195" /db_xref="CDD:461581" Region 250..481 /region_name="Prolidase" /note="E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro; cd01087" /db_xref="CDD:238520" Site order(310,327,338,417,444,467) /site_type="active" /db_xref="CDD:238520" CDS 1..511 /gene="ICP55" /locus_tag="YER078C" /coded_by="NM_001178969.1:1..1536" /experiment="EXISTENCE:direct assay:GO:0004177 aminopeptidase activity [PMID:19720832]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19720832]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19720832|PMID:24769239|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0016485 protein processing [PMID:19837041]" /experiment="EXISTENCE:mutant phenotype:GO:0004177 aminopeptidase activity [PMID:19720832|PMID:19837041]" /experiment="EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:19720832|PMID:19837041]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:19837041]" /note="Mitochondrial aminopeptidase; cleaves N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of aminopeptidase P family; exists in rapid equilibrium between monomer and dimer, with dimer being active species; ortholog of human gene XPNPEP3, which is mutated in rare hereditary kidney disease similar to nephronophthisis" /db_xref="GeneID:856811" /db_xref="SGD:S000000880" ORIGIN 1 mlhrinpvrf smqscqryfs klvspleqhk sntftnrvri pieagqplhe trpfliksge 61 ltpgisaley yerrirlaet lppkscvila gndiqfasga vfypfqqend lfylsgwnep 121 nsvmilekpt dslsdtifhm lvppkdafae kwegfrsgvy gvqeifnade sasindlsky 181 lpkiinrndf iyfdmlstsn psssnfkhik slldgsgnsn rslnsiankt ikpiskriae 241 frkikspqel rimrragqis grsfnqafak rfrnertlds flhykfisgg cdkdayipvv 301 atgsnslcih ytrnddvmfd demvlvdaag slggycadis rtwpnsgkft daqrdlyeav 361 lnvqrdcikl ckasnnyslh diheksitlm kqelknlgid kvsgwnvekl yphyighnlg 421 ldvhdvpkvs ryeplkvgqv itiepglyip neesfpsyfr nvgirieddi aigedtytnl 481 tveavkeidd lenvmqngls tkfeedqvap l // LOCUS NP_878068 54 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER078W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878068 VERSION NP_878068.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184548.3 REFERENCE 1 (residues 1 to 54) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 54) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 54) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 54) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07739. On Jul 30, 2012 this sequence version replaced NP_878068.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..54 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..54 /product="uncharacterized protein" /calculated_mol_wt="6131" CDS 1..54 /locus_tag="YER078W-A" /coded_by="NM_001184548.3:1..165" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466536" /db_xref="SGD:S000028546" ORIGIN 1 mvrlsylrli lppcrlsels slailyqpvi pilistitfq hffkcvhtpc nvyi // LOCUS NP_011002 210 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER079W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011002 VERSION NP_011002.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178970.1 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07740. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..210 /product="uncharacterized protein" /calculated_mol_wt="23066" CDS 1..210 /locus_tag="YER079W" /coded_by="NM_001178970.1:1..633" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein" /db_xref="GeneID:856812" /db_xref="SGD:S000000881" ORIGIN 1 mpdsshsiss kdvasaisly dqsiytnnrs tnldldqrsm spsniasged ritrtnsgcs 61 itsgasmiat kdgiqginvk rdgipkysln llnsmvrkqy dhnngtkspt pktsnmvdpk 121 nkkknkkkkn dkddkykvsh dqtekfykln ttsnsnltsd sttslsdqfy fqksnadsap 181 ldnanyplsd hspslnsmdn ttkhssnvht // LOCUS NP_011003 627 aa linear PLN 30-JUN-2025 DEFINITION Aim9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011003 VERSION NP_011003.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178971.1 REFERENCE 1 (residues 1 to 627) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 627) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 627) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 627) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07741. Method: conceptual translation. FEATURES Location/Qualifiers source 1..627 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..627 /product="Aim9p" /calculated_mol_wt="72283" Region 147..>284 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(147..150,153,155,167,169,203,223..226,279,283..284) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..627 /gene="AIM9" /locus_tag="YER080W" /gene_synonym="FMP29" /coded_by="NM_001178971.1:1..1884" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:14562095]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss" /db_xref="GeneID:856813" /db_xref="SGD:S000000882" ORIGIN 1 mirytvaghs rrcvvgaskr vgaikcitva atkrfisnkp nevftkltnd ndpkrdaffk 61 ytwgswlknd kqekekrftk fsieglnril ndiyiqsnem akapdgkilp pvfnknltvs 121 lvnnvvpkni gkinpnekvq vttlssiheg khhriykvdt nlnkafilri pyplenentl 181 syrirsevat mdfadlklgi kvpkifcygv nslnpvrqpf vlqefiegel lmkdwdplie 241 dgssnqkkyd nvikqvsdfq sklvslklna fgsiyfnndl kdgnekefvk ediydgetnp 301 dlqnrwkigp sverclwrhk shldfhkqmk pflgpwpkks pmdiikntgl leaenaktri 361 amkeagssae lmyprtlkeq ittyenlaki apdlfnvktk aipnmqells prlfhpdldp 421 mniivnkeaq eaylldfega ctkpfilqns pqfiaydgpk iydlkeditd fdklseaekv 481 qyqfmykrtr nqhqwekkln dnnpklitav appvkllrsp yiaaverkte eeyllidesl 541 lqlkevwdif aqnelvnqkk fplnyskedi erhvedlqkl heklistpfa atqgwipqdm 601 fdqllnsgsi vkqengdytv kqpeatk // LOCUS NP_011004 469 aa linear PLN 30-JUN-2025 DEFINITION phosphoglycerate dehydrogenase SER3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011004 VERSION NP_011004.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178972.3 REFERENCE 1 (residues 1 to 469) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 469) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 469) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 469) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07742. On Jul 30, 2012 this sequence version replaced NP_011004.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..469 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..469 /product="phosphoglycerate dehydrogenase SER3" /EC_number="1.1.1.95" /EC_number="1.1.1.399" /calculated_mol_wt="51062" Region 59..469 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" Site order(107..108,130..132,155) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:240653" Site order(131,153,155,159,205..209,227..229,232,257..259, 263..264,267,285..287,311,347,349..350) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:240653" Site order(157..158,161..162,164..166,168..169,172,174,177..178, 181..182,184,186..197,199,219..220,313,316..317,320, 331..332,336..337,339,342..349,351..354,356) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:240653" CDS 1..469 /gene="SER3" /locus_tag="YER081W" /coded_by="NM_001178972.3:1..1410" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0061759 alpha-ketoglutarate reductase activity [PMID:26774271]" /experiment="EXISTENCE:genetic interaction:GO:0061759 alpha-ketoglutarate reductase activity [PMID:26774271]" /experiment="EXISTENCE:mutant phenotype:GO:0004617 phosphoglycerate dehydrogenase activity [PMID:12525494]" /experiment="EXISTENCE:mutant phenotype:GO:0006564 L-serine biosynthetic process [PMID:12525494]" /experiment="EXISTENCE:mutant phenotype:GO:0061759 alpha-ketoglutarate reductase activity [PMID:26774271]" /note="3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); directly phosphorylated by TORC1 in a Pib2-dependent manner; localizes to the cytoplasm; ER3 has a paralog, SER33, that arose from the whole genome duplication" /db_xref="GeneID:856814" /db_xref="SGD:S000000883" ORIGIN 1 mtsidinnlq ntfqqamnms gspgavctsp tqsfmntvpq rlnavkhpki lkpfstgdmk 61 illlenvnqt aitifeeqgy qvefyksslp eeeliekikd vhaigirskt rltsnvlqha 121 knlvcigcfc igtnqvdldy atsrgiavfn spfsnsrsva elviaeiisl arqlgdrsie 181 lhtgtwnkva arcwevrgkt lgiigyghig sqlsvlaeam glhvlyydiv timalgtarq 241 vstldellnk sdfvtlhvpa tpetekmlsa pqfaamkdga yvinasrgtv vdipsliqav 301 kankiagaal dvyphepakn gegsfndeln swtselvslp niiltphigg steeaqssig 361 ievatalsky inegnsvgsv nfpevalksl sydqentvrv lyihqnvpgv lktvndilsn 421 hniekqfsds ngeiaylmad issvdqsdik diyeqlnqts akisirlly // LOCUS NP_011005 554 aa linear PLN 30-JUN-2025 DEFINITION Utp7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011005 VERSION NP_011005.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178973.1 REFERENCE 1 (residues 1 to 554) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 554) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 554) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07743. Method: conceptual translation. FEATURES Location/Qualifiers source 1..554 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..554 /product="Utp7p" /calculated_mol_wt="62186" Region 116..149 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 155..189 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 157..333 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 194..229 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 236..272 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 277..311 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 367..445 /region_name="BING4CT" /note="BING4CT (NUC141) domain; pfam08149" /db_xref="CDD:462375" CDS 1..554 /gene="UTP7" /locus_tag="YER082C" /gene_synonym="KRE31" /coded_by="NM_001178973.1:1..1665" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12150911|PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835|PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835|PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292|PMID:15590835]" /note="Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" /db_xref="GeneID:856815" /db_xref="SGD:S000000884" ORIGIN 1 mghkknghrr qikerenqnk ferstytnna knnhtqtkdk klraglkkid eqykkavssa 61 aatdyllpes ngylepenel ektfkvqqse ikssvdvsta nkaldlslke fgpyhikyak 121 ngthllitgr kghvasmdwr kgqlraelfl netchsatyl qneqyfavaq kkytfiydhe 181 gtelhrlkqh iearhldflp yhyllvtage tgwlkyhdvs tgqlvselrt kagptmamaq 241 npwnavmhlg hsngtvslws psmpeplvkl lsargpvnsi aidrsgyyma ttgadrsmki 301 wdirnfkqlh sveslptpgt nvsisdtgll alsrgphvtl wkdalklsgd skpcfgsmgg 361 nphrntpyms hlfagnkven lgfvpfedll gvghqtgitn livpgagean ydalelnpfe 421 tkkqrqeqev rtllnklpad titldpnsig svdkrsstir lnakdlaqtt mdannkaktn 481 sdipdvkpdv kgknsglrsf lrkktqnvid erklrvqkql dkeknirkrn hqikqglise 541 dhkdvieeal srfg // LOCUS NP_011006 285 aa linear PLN 30-JUN-2025 DEFINITION GET complex subunit GET2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011006 VERSION NP_011006.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178974.1 REFERENCE 1 (residues 1 to 285) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 285) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 285) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 285) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07744. On Oct 2, 2003 this sequence version replaced NP_011006.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..285 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..285 /product="GET complex subunit GET2" /calculated_mol_wt="31362" Region 20..282 /region_name="GET2" /note="GET complex subunit GET2; pfam08690" /db_xref="CDD:400847" CDS 1..285 /gene="GET2" /locus_tag="YER083C" /gene_synonym="HUR2; RMD7" /coded_by="NM_001178974.1:1..858" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:36640319]" /experiment="EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:36640319]" /experiment="EXISTENCE:direct assay:GO:0097051 establishment of protein localization to endoplasmic reticulum membrane [PMID:36640319]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]" /experiment="EXISTENCE:genetic interaction:GO:0043495 protein-membrane adaptor activity [PMID:18724936]" /experiment="EXISTENCE:genetic interaction:GO:0043529 GET complex [PMID:16269340]" /experiment="EXISTENCE:genetic interaction:GO:0071816 tail-anchored membrane protein insertion into ER membrane [PMID:18724936]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:29673596]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]" /experiment="EXISTENCE:mutant phenotype:GO:0032977 membrane insertase activity [PMID:25043001]" /note="Subunit of the GET complex; involved in insertion of tail-anchored proteins proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division; Get1p and Get2p form an aqueous channel for protein translocation and insertion into the membrane" /db_xref="GeneID:856817" /db_xref="SGD:S000000885" ORIGIN 1 mselteaekr rllrerrqkk fsnggassrl nkitgqassh lnaespldap saakttppas 61 vhsatpdike dsnvapqldl lkqlaamqgq gtgkstpqds stpdllslls smntgmpsae 121 gtpsfgqaap aapinqaald yhdyllnrlk awtilvkwvf fllpylylit rpnssvwpay 181 aftqsawfap lrnpsnftri fatfeflsis iyyqllknve hkskiknlqd tnklvklvsl 241 vpegvipvan lkgklitllq ywdllsmlit disfvlivlg lltyl // LOCUS NP_001257673 128 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER084W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257673 VERSION NP_001257673.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270744.1 REFERENCE 1 (residues 1 to 128) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 128) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 128) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 128) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35103. Method: conceptual translation. FEATURES Location/Qualifiers source 1..128 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..128 /product="uncharacterized protein" /calculated_mol_wt="14182" CDS 1..128 /locus_tag="YER084W" /coded_by="NM_001270744.1:1..387" /note="hypothetical protein; expressed at both mRNA and protein levels" /db_xref="GeneID:856816" /db_xref="SGD:S000000886" ORIGIN 1 meelictypy hsnlfmflfl ffcpskrarr ghpkflftlc yksnhlipkl lppslftkrv 61 mlnpsshpps pdfptgssas prvklrpstl wappltvssd faasssstap vtvtdkpvtp 121 avskryqp // LOCUS NP_011008 173 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER085C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011008 VERSION NP_011008.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178976.3 REFERENCE 1 (residues 1 to 173) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 173) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 173) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 173) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07745. On Jul 30, 2012 this sequence version replaced NP_011008.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..173 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..173 /product="uncharacterized protein" /calculated_mol_wt="20353" CDS 1..173 /locus_tag="YER085C" /coded_by="NM_001178976.3:1..522" /note="hypothetical protein" /db_xref="GeneID:856818" /db_xref="SGD:S000000887" ORIGIN 1 mnfkeplvnf lkcvlnnins afshridqlq lqllretnil rvlnrgierl fsenprthsv 61 srivvekdvg crigryvegs kyelvesrak eiqiyyermv feitqelkgd krvfalianl 121 sqrysaerke irnvkvhggr pcnenefqvi pirfkpinle rrarlirkkk tin // LOCUS NP_011009 576 aa linear PLN 30-JUN-2025 DEFINITION threonine ammonia-lyase ILV1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011009 VERSION NP_011009.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178977.1 REFERENCE 1 (residues 1 to 576) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 576) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 576) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 576) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07746. Method: conceptual translation. FEATURES Location/Qualifiers source 1..576 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..576 /product="threonine ammonia-lyase ILV1" /EC_number="4.3.1.19" /calculated_mol_wt="63700" Region 61..575 /region_name="PRK09224" /note="threonine ammonia-lyase IlvA" /db_xref="CDD:236417" CDS 1..576 /gene="ILV1" /locus_tag="YER086W" /gene_synonym="ISO1" /coded_by="NM_001178977.1:1..1731" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0006567 L-threonine catabolic process [PMID:7042346]" /experiment="EXISTENCE:mutant phenotype:GO:0004794 threonine deaminase activity [PMID:5345980]" /experiment="EXISTENCE:mutant phenotype:GO:0009097 isoleucine biosynthetic process [PMID:5345980]" /note="Threonine deaminase, catalyzes first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation" /db_xref="GeneID:856819" /db_xref="SGD:S000000888" ORIGIN 1 msatllkqpl ctvvrqgkqs kvsglnllrl kahlhrqhls psliklhsel kldelqtdnt 61 pdyvrlvlrs svydvinesp isqgvglssr lntnvilkre dllpvfsfkl rgaynmiakl 121 ddsqrnqgvi acsagnhaqg vafaakhlki pativmpvct psikyqnvsr lgsqvvlygn 181 dfdeakaeca klaeergltn ippfdhpyvi agqgtvamei lrqvrtanki gavfvpvggg 241 gliagigayl krvaphikii gvetydaatl hnslqrnqrt plpvvgtfad gtsvrmigee 301 tfrvaqqvvd evvlvntdei caavkdifed trsivepsga lsvagmkkyi stvhpeidht 361 kntyvpilsg anmnfdrlrf vseravlgeg kevfmlvtlp dvpgafkkmq kiihprsvte 421 fsyrynehrh esssevpkay iytsfsvvdr ekeikqvmqq lnalgfeavd isdnelaksh 481 grylvggask vpneriisfe fperpgaltr flgglsdswn ltlfhyrnhg adigkvlagi 541 svpprenltf qkfledlgyt yhdetdntvy qkflky // LOCUS NP_011010 576 aa linear PLN 30-JUN-2025 DEFINITION putative proline--tRNA ligase AIM10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011010 VERSION NP_011010.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178978.1 REFERENCE 1 (residues 1 to 576) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 576) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 576) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 576) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07747. Method: conceptual translation. FEATURES Location/Qualifiers source 1..576 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..576 /product="putative proline--tRNA ligase AIM10" /EC_number="6.1.1.15" /calculated_mol_wt="65749" Region 7..545 /region_name="proS_fam_II" /note="prolyl-tRNA synthetase, family II; TIGR00409" /db_xref="CDD:273063" CDS 1..576 /gene="AIM10" /locus_tag="YER087W" /coded_by="NM_001178978.1:1..1731" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /note="Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss" /db_xref="GeneID:856820" /db_xref="SGD:S000000889" ORIGIN 1 mlkyrtlsrs chifhpksls nntlksettq ellqtvgfvr rsqvglfqwl plglrslnkv 61 snairnrmds dggaievsls aisskalwqa tdrwnnself klkdskgkqy cltatceedi 121 tdlmknyias ykdmpitiyq mtrkyrdeir prggilrgre flmkdaysfa sneedafasf 181 qklddtynki fkdlkipfvs awadsgdigg efskefhlih esgedtlmsc khcgdistld 241 msqsypekdg qysgdvdcky altkdhstli cfyypkdrql nwnlalnamd kdidltlrnk 301 pndhvlqvye kdnedimfsk ilrvmdcrln sksnfpdfpl kkylknnfgq isdvsivdaq 361 eneicgkcee grleplksie vghifllgnk yskplnvkfv dkenknetfv hmgcygigvs 421 rlvgaiaelg rdsngfrwpa imapykvsic tgpnnpensq rlqdvksell ndptmqnlqn 481 dildqfnekl gigariklsh amgiplcviv gskswpnvei evrgirwgek dlwrkqfekr 541 cselqwkctk nehgiekhtv piqhlaevig vllkdm // LOCUS NP_011011 82 aa linear PLN 30-JUN-2025 DEFINITION Arf family guanine nucleotide exchange factor SBH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011011 VERSION NP_011011.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180032.3 REFERENCE 1 (residues 1 to 82) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 82) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 82) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 82) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07748. On Jul 30, 2012 this sequence version replaced NP_011011.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..82 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..82 /product="Arf family guanine nucleotide exchange factor SBH1" /calculated_mol_wt="8580" Region 38..74 /region_name="Sec61_beta" /note="Sec61beta family; pfam03911" /db_xref="CDD:427582" CDS 1..82 /gene="SBH1" /locus_tag="YER087C-B" /gene_synonym="SEB1; YER087C-A" /coded_by="NM_001180032.3:1..249" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:12750387]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0005784 Sec61 translocon complex [PMID:7758110|PMID:8612571]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:31201345]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9252322]" /experiment="EXISTENCE:direct assay:GO:0015450 protein-transporting ATPase activity [PMID:7758110]" /experiment="EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7758110]" /experiment="EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:19857245]" /note="Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; cotranslationally N-acetylated by NatA; SBH1 has a paralog, SBH2, that arose from the whole genome duplication" /db_xref="GeneID:856821" /db_xref="SGD:S000002128" ORIGIN 1 mssptppggq rtlqkrkqgs sqkvaasapk kntnsnnsil kiysdeatgl rvdplvvlfl 61 avgfifsvva lhviskvagk lf // LOCUS NP_011012 670 aa linear PLN 30-JUN-2025 DEFINITION Dot6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011012 VERSION NP_011012.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178979.3 REFERENCE 1 (residues 1 to 670) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 670) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 670) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 670) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07749. On Jul 30, 2012 this sequence version replaced NP_011012.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..670 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..670 /product="Dot6p" /calculated_mol_wt="72918" Region 75..117 /region_name="Myb_DNA-binding" /note="Myb-like DNA-binding domain; pfam00249" /db_xref="CDD:459731" CDS 1..670 /gene="DOT6" /locus_tag="YER088C" /gene_synonym="PBF2" /coded_by="NM_001178979.3:1..2013" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:9755194]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:9755194]" /note="Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:856822" /db_xref="SGD:S000000890" ORIGIN 1 msistslnsa sihlssmdth pqlhsltrqp hssstamskn eaqesspslp assssstsas 61 asassknssk npsswdpqdd lllrhlkevk kmgwkdisqy fpnrtpnacq frwrrlksgn 121 lksnktalid intytgplki thgdetanaq qkpskkveen vltedtaeft ttssipipsr 181 ktslpsfhas msfsqspsnv tpttivsnaa ssmpfapptl paalphhphq hlhhhphhkt 241 lkprsnshsf tnslnqdpiv rsndeekygf ipkvfvrsrr ssfaypqqva itttpsspns 301 shvllssksr rgslanwsrr ssfnvssnnt srrssmilap nsvsnifnvn nsgsntasts 361 ntnsrresvi kkefqqrlnn lsnsggptsn ngpifpnsyt fmdlphsssv sssstlhksk 421 rgsfsghsmk sscnptnlws kdedallmen kkrnlsvmel sillpqrtev eiqwrlnals 481 sdadmlspth spqktlskkt cprmfksgst tdddkgsdke dvmgdgsndd dednvdplhr 541 akqssnktvf sssssnissk dvspdpifsp dpaddssnts dagsrctits dtsssaatmn 601 rtpnsknpqd iallnnfrse aitprpkpss tttsittett nnminhssst ttttnnsplp 661 sintifkdml // LOCUS NP_011013 464 aa linear PLN 30-JUN-2025 DEFINITION type 2C protein phosphatase PTC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011013 VERSION NP_011013.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178980.1 REFERENCE 1 (residues 1 to 464) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 464) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 464) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 464) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07750. Method: conceptual translation. FEATURES Location/Qualifiers source 1..464 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..464 /product="type 2C protein phosphatase PTC2" /EC_number="3.1.3.16" /calculated_mol_wt="50257" Region 23..279 /region_name="PP2C" /note="Protein phosphatase 2C; pfam00481" /db_xref="CDD:395385" Site order(33,37..38,62..64,234,283) /site_type="active" /db_xref="CDD:238083" CDS 1..464 /gene="PTC2" /locus_tag="YER089C" /coded_by="NM_001178980.1:1..1395" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:9528768|PMID:10580002]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:12477803]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12477803|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:1990439 MAP kinase serine/threonine phosphatase activity [PMID:12477803]" /experiment="EXISTENCE:mutant phenotype:GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response [PMID:9528768]" /experiment="EXISTENCE:physical interaction:GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response [PMID:9528768]" /note="Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint; PTC2 has a paralog, PTC3, that arose from the whole genome duplication" /db_xref="GeneID:856823" /db_xref="SGD:S000000891" ORIGIN 1 mgqilsnpvi dkeshsgads ltafglcamq gwrmsmedsh ilepnvltks dkdhiafygi 61 fdghggakva eycgnkivei lqeqksfheg nlpralidtf intdvkllqd pvmkedhsgc 121 tatsilvsks qnllvcgnag dsrtvlatdg nakalsydhk ptlaseksri vaadgfvemd 181 rvngnlalsr aigdfefksn pklgpeeqiv tcvpdilehs ldydrdefvi lacdgiwdcl 241 tsqdcvdlvh lglregktln eissriidvc capttegtgi gcdnmsivvv allkegedva 301 qwsdrmkska hrtsvrsfad krrrvfsyyd fskcndeqvf aittkkpqdk ftrdheaava 361 svtaadnddp mdiddtdadt daenldpssq sksktsgpid lasleallga tggvktdsng 421 nkvtytlpqs alaqllqtmg hdpasshpen dsntdhkagr shlq // LOCUS NP_011014 507 aa linear PLN 30-JUN-2025 DEFINITION anthranilate synthase TRP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011014 VERSION NP_011014.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178981.1 REFERENCE 1 (residues 1 to 507) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 507) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 507) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 507) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07751. Method: conceptual translation. FEATURES Location/Qualifiers source 1..507 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..507 /product="anthranilate synthase TRP2" /EC_number="4.1.3.27" /calculated_mol_wt="56637" Region 37..494 /region_name="trpE_most" /note="anthranilate synthase component I, non-proteobacterial lineages; TIGR00564" /db_xref="CDD:273142" CDS 1..507 /gene="TRP2" /locus_tag="YER090W" /coded_by="NM_001178981.1:1..1524" /experiment="EXISTENCE:direct assay:GO:0004049 anthranilate synthase activity [PMID:3881257]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004049 anthranilate synthase activity [PMID:6323449]" /experiment="EXISTENCE:mutant phenotype:GO:0000162 L-tryptophan biosynthetic process [PMID:8432699]" /experiment="EXISTENCE:physical interaction:GO:0005950 anthranilate synthase complex [PMID:3881257]" /note="Anthranilate synthase; catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p" /db_xref="GeneID:856824" /db_xref="SGD:S000000892" ORIGIN 1 mtasikiqpd idslkqlqqq nddssinmyp vyaylpsldl tphvaylkla qlnnpdrkes 61 fllesaktnn eldrysfigi sprktiktgp tegietdple ilekemstfk vaenvpglpk 121 lsggaigyis ydcvryfepk trrplkdvlr lpeaylmlcd tiiafdnvfq rfqiihnint 181 netsleegyq aaaqiitdiv skltddsspi pypeqppikl nqtfesnvgk egyenhvstl 241 kkhikkgdii qgvpsqrvar ptslhpfniy rhlrtvnpsp ylfyidcldf qiigaspell 301 cksdsknrvi thpiagtvkr gatteeddal adqlrgslkd raehvmlvdl arndinricd 361 plttsvdkll tiqkfshvqh lvsqvsgvlr pektrfdafr sifpagtvsg apkvrameli 421 aelegerrgv yagavghwsy dgktmdncia lrtmvykdgi aylqagggiv ydsdeydeyv 481 etmnkmmanh stivqaeelw adivgsa // LOCUS NP_011015 767 aa linear PLN 30-JUN-2025 DEFINITION 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011015 VERSION NP_011015.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178982.3 REFERENCE 1 (residues 1 to 767) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 767) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 767) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 767) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07752. On Jul 30, 2012 this sequence version replaced NP_011015.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..767 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..767 /product="5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase" /EC_number="2.1.1.14" /calculated_mol_wt="85729" Region 7..764 /region_name="met_syn_B12ind" /note="5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; TIGR01371" /db_xref="CDD:273583" CDS 1..767 /gene="MET6" /locus_tag="YER091C" /coded_by="NM_001178982.3:1..2304" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:mutant phenotype:GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity [PMID:3542720]" /experiment="EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:1101032]" /note="Cobalamin-independent methionine synthase; involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs" /db_xref="GeneID:856825" /db_xref="SGD:S000000893" ORIGIN 1 mvqsavlgfp rigpnrelkk ategywngki tvdelfkvgk dlrtqnwklq keagvdiips 61 ndfsfydqvl dlsllfnvip drytkydlsp idtlfamgrg lqrkatetek avdvtalemv 121 kwfdsnyhyv rptfskttqf klngqkpvde fleakelgih trpvllgpvs ylflgkadkd 181 sldleplsll eqllplytei lsklasagat evqidepvlv ldlpanaqaa ikkaytyfge 241 qsnlpkitla tyfgtvvpnl daikglpvaa lhvdfvrape qfdevvaaig nkqtlsvgiv 301 dgrniwkndf kkssaivnka ieklgadrvv vatsssllht pvdlnnetkl daeikgffsf 361 atqkldevvv itknvsgqdv aaaleanaks vesrgkskfi hdaavkarva sidekmstra 421 apfeqrlpeq qkvfnlplfp tttigsfpqt kdirinrnkf nkgtisaeey ekfinseiek 481 virfqeeigl dvlvhgeper ndmvqyfgeq ingyaftvng wvqsygsryv rppiivgdls 541 rpkamsvkes vyaqsitskp vkgmltgpit clrwsfprdd vdqktqamql alalrdevnd 601 leaagikviq vdepalregl plregtersa yytwaaeafr vatsgvankt qihshfcysd 661 ldpnhikald advvsiefsk kddanyiaef knypnhiglg lfdihsprip skdefiakis 721 tilksypaek fwvnpdcglk trgweetrls lthmveaaky freqykn // LOCUS NP_011017 125 aa linear PLN 30-JUN-2025 DEFINITION Ies5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011017 VERSION NP_011017.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178983.3 REFERENCE 1 (residues 1 to 125) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 125) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 125) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 125) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07753. On Jul 30, 2012 this sequence version replaced NP_011017.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..125 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..125 /product="Ies5p" /calculated_mol_wt="14181" Region 11..123 /region_name="IES5" /note="Ino80 complex subunit 5; pfam17335" /db_xref="CDD:407440" CDS 1..125 /gene="IES5" /locus_tag="YER092W" /coded_by="NM_001178983.3:1..378" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Non-essential INO80 chromatin remodeling complex subunit; deletion affects telomere maintenance via recombination" /db_xref="GeneID:856827" /db_xref="SGD:S000000894" ORIGIN 1 mpskdpesvi dkeirkisar ndelikqdgt lkreyttllr kvssvitvln siddadtgsa 61 etelprlisq atvekvpelk wyndqislit ekleddedie vpeelmdayt lyketpllyn 121 dthtp // LOCUS NP_011018 1430 aa linear PLN 30-JUN-2025 DEFINITION TORC2 complex subunit TSC11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011018 VERSION NP_011018.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178984.1 REFERENCE 1 (residues 1 to 1430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1430) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07754. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1430 /product="TORC2 complex subunit TSC11" /calculated_mol_wt="164238" Region 23..>323 /region_name="PRK08581" /note="amidase domain-containing protein" /db_xref="CDD:236304" Region 326..669 /region_name="RICTOR_N" /note="Rapamycin-insensitive companion of mTOR, N-term; pfam14664" /db_xref="CDD:464246" Region 853..957 /region_name="RICTOR_M" /note="Rapamycin-insensitive companion of mTOR, middle domain; pfam14666" /db_xref="CDD:464248" Region 977..1081 /region_name="RasGEF_N_2" /note="Rapamycin-insensitive companion of mTOR RasGEF_N domain; pfam14663" /db_xref="CDD:464245" Region 1147..1217 /region_name="RICTOR_V" /note="Rapamycin-insensitive companion of mTOR, domain 5; pfam14668" /db_xref="CDD:464249" CDS 1..1430 /gene="TSC11" /locus_tag="YER093C" /gene_synonym="AVO3" /coded_by="NM_001178984.1:1..4293" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:30969890]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:15809876]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:9804843]" /experiment="EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:15809876]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:15809876]" /experiment="EXISTENCE:mutant phenotype:GO:0043495 protein-membrane adaptor activity [PMID:30969890]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:16002396]" /experiment="EXISTENCE:mutant phenotype:GO:0072659 protein localization to plasma membrane [PMID:30969890]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]" /note="Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; contains an N-terminal armadillo repeat region necessary for recruitment to the PM and for anchoring Tor2p and Avo1p at the PM; acts along with Avo1p as a scaffold important for integrity of the TORC2 complex; involved in sphingolipid metabolism; contains a RasGEFN domain" /db_xref="GeneID:856828" /db_xref="SGD:S000000895" ORIGIN 1 msiphsakqs splssrrrsv tnttplltpr hsrdnsstqi ssaknitsss pstitnessk 61 rnkqnlvlst sfistkrlen sapsptsplm arrtrstmtk allnlkaein nqyqelarlr 121 kkkddiehlr dstisdiysg systnhlqkh smrirantql reidnsikrv ekhifdlkqq 181 fdkkrqrslt tsssikadvg sirnddgqnn dseelgdhds ltdqvtldde ylttptsgte 241 rnsqqnlnrn stvnsrnnen hstlsipdld gsnkvnltgd tekdlgdlen enqiftsttt 301 eaatwlvsdy mqsfqeknvn pdfiaqkang lvtllkehse irkdlvltsf mssiqnllln 361 gnkliaasay rvcrylinss ifidellelr ldafiiisla kdnsfqiere qalkmvrrfi 421 eynngvtqgi mqaiiscvek pedslrhmal etllelcfva pemvkecrgm rviegflqdy 481 tsfslasvil dtilqlmath ktrqhfledf nvsvlttvfs dtntksnvnv ekmqnastli 541 sitlnsyngf mlfsnnnfkp lkqlvsffqi picaqylidi fldvlkikpl pykprgrhsh 601 sfkpipsqyy kecmsvnqrl alivlilens efvphllell needrddhlv akgrylltey 661 fnlrmnlvdk kytsvskpiy kenftyvnet fqfkkiaykm nrnrntigms gidyaqniks 721 fsknikentl lrevddfrfr rmvydskvlq tkdftrwnwn iinellegpl lnkkqleelv 781 kstkfirrll vfyrplrlrf snvnkgakls qkyvqvgcqf fktltatpeg mkilmddtki 841 ipqlaslmfr amegnisgni fnknklreki ifgyfkfigi ltqskngvhi ltrwnfftvi 901 ykmfqfeskl glefllltip eldlkysshc rviigkalvv anekvrieat khigdklkel 961 lstkesdlkl kankvklqqf kmemltrqly dlspsvvava dqalyeciva gngseelgts 1021 frmflnqmvf irspilfell srpygfqlln einfvkeerd swlskkniey vhiveeflkk 1081 nesinakslt fqqksrlplh fyesltkted gilllsqtgd lvtfmnvikk yvngnnmatv 1141 enakeildlk aalwcvgfig stelgiglld nyslvediie vaynasvtsv rftafyvlgl 1201 ismtregcei ldemgwnccv svqdepigia lpnrldrfls ynehkwsafg eysdemivfn 1261 ksdgdliekc lpiefdldkl lkekdtaenp lnekiitnky dnditsqtit vsgensslfa 1321 neglsspyvt qyrndddsie skvlhivsql gnhilsnhav keiteinnky gprlfenekm 1381 ffkvfnmmsk yrfkphvrkf lcglfinnra lenvirhdnk rdkrpanftr // LOCUS NP_011019 137 aa linear PLN 30-JUN-2025 DEFINITION Aim11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011019 VERSION NP_011019.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180860.1 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07755. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..137 /product="Aim11p" /calculated_mol_wt="15622" CDS 1..137 /gene="AIM11" /locus_tag="YER093C-A" /gene_synonym="GEP8" /coded_by="NM_001180860.1:1..414" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /note="hypothetical protein; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; localizes to the peroxisome in glucose; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication" /db_xref="GeneID:856829" /db_xref="SGD:S000002960" ORIGIN 1 mieekkelkk rrvlqmarfy gaaaftlitm rlisraikvr kyvpsifqqn yklppfsqrn 61 eamsaltyas aasigtfstl ifgfcwaldi starefvfkt refmslpqal etdtsmdeet 121 skltkqlqdl lssennk // LOCUS NP_011020 205 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit beta 3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011020 VERSION NP_011020.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178985.3 REFERENCE 1 (residues 1 to 205) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 205) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 205) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 205) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07756. On Jul 30, 2012 this sequence version replaced NP_011020.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..205 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..205 /product="proteasome core particle subunit beta 3" /calculated_mol_wt="22474" Region 8..201 /region_name="proteasome_beta_type_3" /note="proteasome beta type-3 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03759" /db_xref="CDD:239728" Site order(10,26,28,42,141,178,181..182) /site_type="active" /db_xref="CDD:239728" Site order(28,31,33..38,57,59,74,86,89..90,92..93,96,99,125,127, 129..132,136,144..145,147..148,151..153,169,176..179, 182..183) /site_type="other" /note="beta subunit interaction site [polypeptide binding]" /db_xref="CDD:239728" CDS 1..205 /gene="PUP3" /locus_tag="YER094C" /gene_synonym="SCS32" /coded_by="NM_001178985.3:1..618" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /experiment="EXISTENCE:genetic interaction:GO:0061133 endopeptidase activator activity [PMID:9207060]" /note="Beta 3 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit C10" /db_xref="GeneID:856830" /db_xref="SGD:S000000896" ORIGIN 1 msdpssingg ivvamtgkdc vaiacdlrlg sqslgvsnkf ekifhyghvf lgitglatdv 61 ttlnemfryk tnlyklkeer aiepetftql vssslyerrf gpyfvgpvva ginsksgkpf 121 iagfdligci deakdfivsg tasdqlfgmc eslyepnlep edlfetisqa llnaadrdal 181 sgwgavvyii kkdevvkryl kmrqd // LOCUS NP_011021 400 aa linear PLN 30-JUN-2025 DEFINITION recombinase RAD51 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011021 VERSION NP_011021.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178986.3 REFERENCE 1 (residues 1 to 400) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 400) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 400) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 400) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07757. On Jul 30, 2012 this sequence version replaced NP_011021.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..400 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..400 /product="recombinase RAD51" /calculated_mol_wt="42832" Region 83..397 /region_name="recomb_RAD51" /note="DNA repair protein RAD51; TIGR02239" /db_xref="CDD:274048" CDS 1..400 /gene="RAD51" /locus_tag="YER095W" /gene_synonym="MUT5" /coded_by="NM_001178986.3:1..1203" /experiment="EXISTENCE:direct assay:GO:0000086 G2/M transition of mitotic cell cycle [PMID:32083180]" /experiment="EXISTENCE:direct assay:GO:0000150 DNA strand exchange activity [PMID:8066464]" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11459983]" /experiment="EXISTENCE:direct assay:GO:0000262 mitochondrial chromosome [PMID:26540255]" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9427283]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:26540255]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:32083180]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:20371520|PMID:32083180]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:26540255]" /experiment="EXISTENCE:direct assay:GO:0006310 DNA recombination [PMID:22955832]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:8066464]" /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:10506208]" /experiment="EXISTENCE:direct assay:GO:0042148 DNA strand invasion [PMID:8066464|PMID:9271413]" /experiment="EXISTENCE:mutant phenotype:GO:0000709 meiotic joint molecule formation [PMID:1581961]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:25822194]" /experiment="EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:32083180]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:7026973]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:7026973]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:16581767]" /experiment="EXISTENCE:mutant phenotype:GO:0043504 mitochondrial DNA repair [PMID:26540255]" /note="Strand exchange protein; forms helical filament with DNA that searches for homology; involved in recombinational repair of DNA DSBs during vegetative growth and meiosis; phosphorylation by Cdc28p in G2/M phase promotes DNA binding, strand invasion, and primer extension; L1 and L2 motifs of DNA binding site I have critical roles in ensuring DNA fidelity during meiotic recombination; RAD51 and RAD4 pathways confer resistance to benzo[a]pyrene dihydrodiol; homolog of Dmc1p and bacterial RecA" /db_xref="GeneID:856831" /db_xref="SGD:S000000897" ORIGIN 1 msqvqeqhis esqlqygngs lmstvpadls qsvvdgngng ssedieatng sgdggglqeq 61 aeaqgemede aydeaalgsf vpieklqvng itmadvkklr esglhtaeav ayaprkdlle 121 ikgiseakad kllneaarlv pmgfvtaadf hmrrselicl ttgsknldtl lgggvetgsi 181 telfgefrtg ksqlchtlav tcqipldigg gegkclyidt egtfrpvrlv siaqrfgldp 241 ddalnnvaya raynadhqlr lldaaaqmms esrfslivvd svmalyrtdf sgrgelsarq 301 mhlakfmral qrladqfgva vvvtnqvvaq vdggmafnpd pkkpiggnim ahssttrlgf 361 kkgkgcqrlc kvvdspclpe aecvfaiyed gvgdpreede // LOCUS NP_011022 512 aa linear PLN 30-JUN-2025 DEFINITION Shc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011022 VERSION NP_011022.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178987.1 REFERENCE 1 (residues 1 to 512) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 512) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 512) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 512) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07758. Method: conceptual translation. FEATURES Location/Qualifiers source 1..512 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..512 /product="Shc1p" /calculated_mol_wt="56447" Region <61..257 /region_name="PTZ00176" /note="erythrocyte membrane protein 1 (PfEMP1); Provisional" /db_xref="CDD:140204" Region 302..330 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region <314..489 /region_name="TPR" /note="TPR repeat [General function prediction only]; COG0790" /db_xref="CDD:440553" Region 337..366 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 373..402 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" CDS 1..512 /gene="SHC1" /locus_tag="YER096W" /coded_by="NM_001178987.1:1..1539" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:15755916]" /experiment="EXISTENCE:direct assay:GO:0030437 ascospore formation [PMID:11918806]" /experiment="EXISTENCE:genetic interaction:GO:0006031 chitin biosynthetic process [PMID:11918806]" /experiment="EXISTENCE:genetic interaction:GO:0008047 enzyme activator activity [PMID:11918806]" /note="Sporulation-specific activator of Chs3p (chitin synthase III); required for the synthesis of the chitosan layer of ascospores; transcriptionally induced at alkaline pH; SHC1 has a paralog, SKT5, that arose from the whole genome duplication" /db_xref="GeneID:856832" /db_xref="SGD:S000000898" ORIGIN 1 msmticsntp gaypeigayn evdkqlessg fssdssliln kpevrqywss vsshisrsgd 61 vftndkekis ssigedamdi daspslieky nsfptrkilp eqdefendve ddassslkek 121 sqgsceieia seisseilng tsadgnsefh dfaepppsqn esvalsfsqs ndldflnnps 181 gsgssndinr stssislprh vsldfnvyns lcltnevtas eshnvakfhl gkknkksllp 241 rwktiemyge vvkktqdiys nfqyaqyilr vgldteklhe lvkeledesn sfsvdslkey 301 lvndakvilk klsavgypda qyllgdayss gvfgkiknrr afllfsaaak rmhiesvyrt 361 aicyecglgv trnapkavnf ltfaatknhp aamyklgvys yhglmglpdd iltkmdgyrw 421 lrratsmass fvcgapfela niymtgykdl iisdpdyama lyekaaalgh tesarileda 481 rrsggfvsrg hppsaqkyhk tsheavaakk li // LOCUS NP_011024 754 aa linear PLN 30-JUN-2025 DEFINITION putative ubiquitin-specific protease UBP9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011024 VERSION NP_011024.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178989.1 REFERENCE 1 (residues 1 to 754) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 754) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 754) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 754) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07759. Method: conceptual translation. FEATURES Location/Qualifiers source 1..754 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..754 /product="putative ubiquitin-specific protease UBP9" /EC_number="3.4.19.12" /calculated_mol_wt="86113" Region 135..>215 /region_name="COG5533" /note="Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]" /db_xref="CDD:444284" Region 135..>154 /region_name="Peptidase_C19" /note="Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cl02553" /db_xref="CDD:470612" Region 390..665 /region_name="Peptidase_C19" /note="Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; cl02553" /db_xref="CDD:470612" CDS 1..754 /gene="UBP9" /locus_tag="YER098W" /coded_by="NM_001178989.1:1..2265" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative ubiquitin-specific protease that cleaves ubiquitin-protein fusions; UBP9 has a paralog, UBP13, that arose from the whole genome duplication" /db_xref="GeneID:856835" /db_xref="SGD:S000000900" ORIGIN 1 mikrwlsvnr kkshpekntq gndeinrkat slkktkgsgd psiakspsak sstssipsnl 61 asherrskfs sqtdnlagnk hyhehyhnma stsdereyds sttyedrafd tessilftti 121 tdlmpygdgs nkvfgyenfg ntcycnsvlq clynipefrc nvlryperva avnrirksdl 181 kgskirvftn esfetstnsg nsntgyqsnd nedahnhhhl qqsdqdnsss stqekqnnfe 241 rkrnsfmgfg kdksnykdsa kkddnnemer pqpvhtvvma sdtlteklhe gckkiivgrp 301 llkqsdslsk asttdcqans hcqcdsqgsr itsvdddvlv npescndavn nsnnnkentf 361 ptseqrkkaa lirgpvlnvd hllypteeat lynglkdife sitenlsltg ivsptefvki 421 lkkenvlfnt mmqqdahefl nfllndfsey iqrnnprmrf gpqktdnsnd nfitdlfkgt 481 ltnrikcltc dnitsrdepf ldfpievqgd eetdiqkmlk syhqremlng vnkfycnkcy 541 glqeaermvg lkqlphilsl hlkrfkysee qksniklfnk ilypltldvs stfntsvykk 601 yelsgvvihm gsgpqhghyv cicrnekfgw llyddetves ikeetvlqft ghpgdqttay 661 vlfyketqad ktenqnenid tssqdqmqtd nnieqlikcd dwlrdrklra aanierkktl 721 gnipevktae tktplndkkr nkqkrksril sfik // LOCUS NP_011025 318 aa linear PLN 30-JUN-2025 DEFINITION ribose phosphate diphosphokinase subunit PRS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011025 VERSION NP_011025.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178990.3 REFERENCE 1 (residues 1 to 318) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 318) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 318) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 318) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07760. On Jul 30, 2012 this sequence version replaced NP_011025.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..318 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..318 /product="ribose phosphate diphosphokinase subunit PRS2" /EC_number="2.7.6.1" /calculated_mol_wt="34634" Region 4..313 /region_name="PrsA" /note="Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; COG0462" /db_xref="CDD:440230" CDS 1..318 /gene="PRS2" /locus_tag="YER099C" /coded_by="NM_001178990.3:1..957" /experiment="EXISTENCE:direct assay:GO:0002189 ribose phosphate diphosphokinase complex [PMID:15280369]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004749 ribose phosphate diphosphokinase activity [PMID:15280369]" /experiment="EXISTENCE:genetic interaction:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:15280369]" /experiment="EXISTENCE:mutant phenotype:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:10212224]" /note="5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS2 has a paralog, PRS4, that arose from the whole genome duplication" /db_xref="GeneID:856836" /db_xref="SGD:S000000901" ORIGIN 1 mstnsiklla gnshpglael isqrlgvpls kvgvyqysnk etsvtigesi rdedvyiiqt 61 gygeheindf lmelliliha cktasvrrit avipnfpyar qdkkdksrap itaklianll 121 etagcdhvit mdlhasqiqg ffhipvdnly gepsvlnyir tktdfnnail vspdaggakr 181 vasladkldm nfalihkerq kanevsrmll vgdvagkscl liddmadtcg tlvkacdtlm 241 dhgakeviai vthgifsgsa reklinsrls rivctntvpv dldldivdqv disptiaeai 301 rrlhngesvs ylfthapv // LOCUS NP_011026 250 aa linear PLN 30-JUN-2025 DEFINITION E2 ubiquitin-conjugating protein UBC6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011026 VERSION NP_011026.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178991.3 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07761. On Jul 30, 2012 this sequence version replaced NP_011026.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..250 /product="E2 ubiquitin-conjugating protein UBC6" /EC_number="2.3.2.23" /calculated_mol_wt="28252" Region 8..140 /region_name="UBCc_UBE2J" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 J1, J2 and related proteins; cd23799" /db_xref="CDD:467419" CDS 1..250 /gene="UBC6" /locus_tag="YER100W" /gene_synonym="DOA2" /coded_by="NM_001178991.3:1..753" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:8396728]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8396728]" /experiment="EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:8396728]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:8641272|PMID:8781238|PMID:8396728]" /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:19345192]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:8396728|PMID:18191224]" /experiment="EXISTENCE:mutant phenotype:GO:0006513 protein monoubiquitination [PMID:8396728]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:8393731|PMID:18191224|PMID:8781238|PMID:8641272]" /note="Ubiquitin-conjugating enzyme involved in ERAD; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway; ER-associated protein degradation is also known as ERAD" /db_xref="GeneID:856837" /db_xref="SGD:S000000902" ORIGIN 1 matkqahkrl tkeyklmven pppyilarpn ednilewhyi itgpadtpyk ggqyhgtltf 61 psdypykppa irmitpngrf kpntrlclsm sdyhpdtwnp gwsvstilng llsfmtsdea 121 ttgsittsdh qkktlarnsi syntfqnvrf klifpevvqe nvetlekrkl degdaantgd 181 etedpftkaa kekvisleei ldpedrirae qalrqsenns kkdgkepnds ssmvyigiai 241 flflvglfmk // LOCUS NP_011027 430 aa linear PLN 30-JUN-2025 DEFINITION Ast2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011027 VERSION NP_011027.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178992.1 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07762. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..430 /product="Ast2p" /calculated_mol_wt="48240" Region 50..427 /region_name="AST1_like" /note="AST1 is a cytoplasmic protein associated with the periplasmic membrane in yeast; cd08247" /db_xref="CDD:176209" Site order(89..91,94,179,183,207..210,212..213,233..234,243,260, 304..305,307,327..328,366..368) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:176209" CDS 1..430 /gene="AST2" /locus_tag="YER101C" /coded_by="NM_001178992.1:1..1293" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006612 protein targeting to membrane [PMID:7822420]" /note="Lipid raft associated protein; overexpression restores Pma1p localization to lipid rafts which is required for targeting of Pma1p to the plasma membrane; sometimes classified in the medium-chain dehydrogenase/reductases (MDRs) superfamily; AST2 has a paralog, AST1, that arose from the whole genome duplication" /db_xref="GeneID:856838" /db_xref="SGD:S000000903" ORIGIN 1 maekilenkd pkleamtvdh evsapkpipv deptltrvar plrhvrhipv kslvfhskhg 61 pitfsyenki klpisknklv vqvnyvglnp vdmkirngyt kpiygeagig reysgvithv 121 gdnltnrwnv gddvygiyyh pklaigalqs sllidprvdp ilmrpkntls pekaagslfc 181 lgtalnllaq lkekdqlnte snvlinggts svgmfaiqll kryykvskkl vvvtsgngaa 241 vlsehfpdlk deiifinyls crgksskplr rmldtgkvvd yddfntlket edytqgkfnv 301 vldfiggydi lshsssliha kgayittvgd yvgnykkdvf dswdnpsana rkmfgsmlws 361 ydyshfyfdp nikiipkknd wihecgklln egvvdcvvdk vyswknfkea fsymatqraq 421 gklimkvegf // LOCUS NP_011028 200 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS8 RPS8B [Saccharomyces cerevisiae S288C]. ACCESSION NP_011028 VERSION NP_011028.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178993.1 REFERENCE 1 (residues 1 to 200) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 200) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 200) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 200) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07763. Method: conceptual translation. FEATURES Location/Qualifiers source 1..200 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..200 /product="40S ribosomal protein eS8 RPS8B" /calculated_mol_wt="22359" Region 1..200 /region_name="PTZ00148" /note="40S ribosomal protein S8; Provisional" /db_xref="CDD:240292" CDS 1..200 /gene="RPS8B" /locus_tag="YER102W" /coded_by="NM_001178993.1:1..603" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S8, no bacterial homolog; RPS8B has a paralog, RPS8A, that arose from the whole genome duplication" /db_xref="GeneID:856839" /db_xref="SGD:S000000904" ORIGIN 1 mgisrdsrhk rsatgakraq frkkrkfelg rqpantkiga krihsvrtrg gnkkyralri 61 etgnfswase giskktriag vvyhpsnnel vrtntltkaa ivqidatpfr qwfeahygqt 121 lgkkknvkee etvaksknae rkwaaraasa kiessvesqf sagrlyacis srpgqsgrcd 181 gyilegeela fylrrltakk // LOCUS NP_011029 642 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family chaperone SSA4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011029 VERSION NP_011029.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178994.3 REFERENCE 1 (residues 1 to 642) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 642) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 642) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 642) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07764. On Jul 30, 2012 this sequence version replaced NP_011029.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..642 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..642 /product="Hsp70 family chaperone SSA4" /calculated_mol_wt="69520" Region 4..642 /region_name="PTZ00009" /note="heat shock 70 kDa protein; Provisional" /db_xref="CDD:240227" CDS 1..642 /gene="SSA4" /locus_tag="YER103W" /gene_synonym="YG107" /coded_by="NM_001178994.3:1..1929" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11279056]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11279056]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:9789005]" /experiment="EXISTENCE:genetic interaction:GO:0051082 unfolded protein binding [PMID:9789005]" /experiment="EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:8754838]" /note="Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; translocates to the nucleus under Cd2+ stress to mediate tolerance by regulating VHS1 expression; cytoplasmic protein that concentrates in nuclei upon starvation; member of the HSP70 family; SSA4 has a paralog, SSA3, that arose from the whole genome duplication" /db_xref="GeneID:856840" /db_xref="SGD:S000000905" ORIGIN 1 mskavgidlg ttyscvahfa ndrveiiand qgnrttpsyv aftdterlig daaknqaamn 61 phntvfdakr ligrkfddpe vtndakhypf kvidkggkpv vqveykgetk tftpeeissm 121 iltkmketae nflgtevkda vvtvpayfnd sqrqatkdag tiaglnvlri ineptaaaia 181 ygldkksqke hnvlifdlgg gtfdvsllsi degvfevkat agdthlgged fdsrlvnfla 241 eefkrknkkd lttnqrslrr lrtaaerakr tlsssaqtsi eidslfegid fytsitrarf 301 eelcadlfrs tlepvekvla dskldksqid eivlvggstr ipkvqklvsd ffngkepnrs 361 inpdeavayg aavqaailtg dqssttqdll lldvaplslg ietaggimtk liprnstipt 421 kksevfstya dnqpgvliqv fegertrtkd nnllgkfels gippaprgvp qievtfdida 481 ngilnvsave kgtgksnkit itndkgrlsk edidkmvaea ekfkaedeqe aqrvqaknql 541 esyaftlkns vsennfkekv geedarklea aaqdainwld asqaasteey kerqkelegv 601 anpimskfyg aaggapgagp vpgagagptg apdngptvee vd // LOCUS NP_011030 208 aa linear PLN 30-JUN-2025 DEFINITION Rtt105p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011030 VERSION NP_011030.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178995.3 REFERENCE 1 (residues 1 to 208) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 208) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 208) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 208) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07765. On Jul 30, 2012 this sequence version replaced NP_011030.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..208 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..208 /product="Rtt105p" /calculated_mol_wt="24282" CDS 1..208 /gene="RTT105" /locus_tag="YER104W" /coded_by="NM_001178995.3:1..627" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:30065069]" /experiment="EXISTENCE:direct assay:GO:0140597 protein carrier chaperone [PMID:30065069]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:33724421]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:34140406]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:34140406]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:30065069]" /experiment="EXISTENCE:mutant phenotype:GO:0010526 transposable element silencing [PMID:11779788]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:33724421]" /note="Chaperone for Replication Protein A complex (RPA); involved in nuclear import of RPA and its binding to ssDNA at replication forks; has a role in regulation of Ty1 transposition" /db_xref="GeneID:856841" /db_xref="SGD:S000000906" ORIGIN 1 mysnhnlnsd dccfdwneek aaelqrtgvs fdrsltpqsl rtstrrlsee nkqqsgtmhi 61 dtspsvvsdi issrrdrsqd ffgphssspi apserqradq rsrlesmrlt rrrdkmtkvr 121 gglekmeemi mqgehlremq rlkqeaqkna lpsdmaeyme wqnnedledd ellafiekqe 181 tyknelehfl nnanknvyen nsypnsht // LOCUS NP_011031 1391 aa linear PLN 30-JUN-2025 DEFINITION Nup157p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011031 VERSION NP_011031.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178996.1 REFERENCE 1 (residues 1 to 1391) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1391) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1391) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1391) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07766. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1391 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1391 /product="Nup157p" /calculated_mol_wt="156519" Region 73..1391 /region_name="NUP170" /note="Nuclear pore complex subunit [Intracellular trafficking and secretion]; COG5308" /db_xref="CDD:227624" CDS 1..1391 /gene="NUP157" /locus_tag="YER105C" /coded_by="NM_001178996.1:1..4176" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:24062435]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:24062435]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0044611 nuclear pore inner ring [PMID:18046406]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:19414608]" /experiment="EXISTENCE:genetic interaction:GO:0051292 nuclear pore complex assembly [PMID:19414608]" /experiment="EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479|PMID:20098417]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /note="Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and tethering of DNA to the nuclear periphery; both Nup170p and NUP157p are similar to human Nup155p; NUP157 has a paralog, NUP170, that arose from the whole genome duplication" /db_xref="GeneID:856842" /db_xref="SGD:S000000907" ORIGIN 1 mystplkkri dydretftas aslggnrlrn rprddqnngk pnlssrsfls erktrkdvln 61 kygeagntie selrdvtthv kisgltssep lqlasefvqd lsfrdrntpi ldnpdyyskg 121 ldynfsdevg glgaftpfqr qqvtnipdev lsqvsnteik sdmgifleln ycwitsdnkl 181 ilwninnsse yhcideieht ilkvklvkps pntfvssven llivatlfdi yiltisfndr 241 thelnifntg lkvnvtgfnv sniisyertg qifftgatdg vnvwelqync senlfnsksn 301 kicltksnla nllptklips ipggkliqkv legdagteee tisqlevdqs rgvlhtlstk 361 sivrsylits nglvgpvlid aahirrgmna lgvknsplls nrafkiakiv sismcenndl 421 flavitttgv rlyfkgsisr rsigslklds vkfpptsiss sleqnksfii ghhplnthdt 481 gplstqkass tyinttcast iispgiyftc vrkransgel skgitnkall enkeehklyv 541 sapdygilkn ygkyvental ldttdeikei vpltrsfnyt stpqgyanvf asqysaeplk 601 vavltsnale iycyrtpdev feslienplp fihsyglsea cstalylack fnksehikss 661 alaffsagip gvveikpkss resgsvppis qnlfdksgec dgivlsprfy gsallitrlf 721 sqiweervfv fkrasktekm dafgisitrp qveyylssis vladffnihr psfvsfvppk 781 gsnaitasda esiamnalil linsikdals linvfyedid afksllntlm gaggvydskt 841 reyffdlkfh dlftpnaktk qlikeiliev vnaniasgts adyivnvlke rfgsfchsad 901 ilcyragehl eaaqkfemid skisrnhldt aidlyercae nielcelrrv vdimvklnyq 961 pktvgfllrf adkidkgnqa qeyvsrgcnt adprkvfydk rinvytlife ivksvddyts 1021 ieqspsiani sifspasslk krvysvimns nnrffhycfy dwlvankrqd yllrldsqfv 1081 lpylkeraek sleisnllwf ylfkeehfle aadvlyalas sdfdlklser ieclarangl 1141 cdsstsfdqk palvqlseni helfdiasiq ddllnlvrne tridedyrkq ltlklngrvl 1201 plsdlfndca dpldyyeikl rifkvsqfkd ekviqgewnr lldsmknaps pdvgsvgqes 1261 flssisntli rigkttrdtd vvfpvhflmn kilesfidks saadgsvcsm fllagvshlk 1321 lyyilsriie nsegnvelak kemvwlikdw yqsdsdlrgs iapeqikkle kydpntdpvq 1381 dyvkdrhhgl k // LOCUS NP_011032 302 aa linear PLN 30-JUN-2025 DEFINITION Mam1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011032 VERSION NP_011032.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178997.1 REFERENCE 1 (residues 1 to 302) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 302) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 302) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 302) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07767. Method: conceptual translation. FEATURES Location/Qualifiers source 1..302 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..302 /product="Mam1p" /calculated_mol_wt="35622" Region 4..258 /region_name="MAM1" /note="Monopolin complex protein MAM1; pfam10434" /db_xref="CDD:371048" CDS 1..302 /gene="MAM1" /locus_tag="YER106W" /coded_by="NM_001178997.1:1..909" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11163190|PMID:12663816|PMID:23861669]" /experiment="EXISTENCE:direct assay:GO:0033551 monopolin complex [PMID:12689592]" /experiment="EXISTENCE:genetic interaction:GO:0010789 meiotic sister chromatid cohesion involved in meiosis I [PMID:15062096]" /experiment="EXISTENCE:genetic interaction:GO:0051455 spindle attachment to meiosis I kinetochore [PMID:23861669]" /experiment="EXISTENCE:mutant phenotype:GO:0010789 meiotic sister chromatid cohesion involved in meiosis I [PMID:15062096]" /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0045143 homologous chromosome segregation [PMID:11163190]" /experiment="EXISTENCE:mutant phenotype:GO:0051455 spindle attachment to meiosis I kinetochore [PMID:11163190]" /note="Monopolin; meiosis-specific kinetochore-associated protein involved in monopolar attachment of sister kinetochores to the meiotic spindle; subunit of monopolin, a complex that prevents biorientation of sister kinetochores to ensure homolog biorientation during meiosis I; regulates the conformation, enzyme kinetics and substrate specificity of the Dsn1p kinase, Hrr1p; expressed only during the first meiotic division" /db_xref="GeneID:856843" /db_xref="SGD:S000000908" ORIGIN 1 mrekrtisnk dtnylkfpnk lqrysrflsr kisntspekq pkknikehcl ssyhkehsvk 61 pkqnsgnvaa kedkdtqhlq nnvaneeate cltrsnlkkl qekifdreln diacdhclcs 121 tenrrdikys rlwflfelem senwnenlrl scynkyvysa ideswkmeni llkeqekhye 181 yfpigqllip nnidytnkqk rkeniedlti eidsiietnh qkkrflpqsv likredeiaf 241 ddfhldarkv lndlsatsen pfssspntkk ikskgktlev vpkkknkkii galerklhid 301 en // LOCUS NP_011033 365 aa linear PLN 30-JUN-2025 DEFINITION RNA export factor GLE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011033 VERSION NP_011033.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001178998.3 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07768. On Jul 30, 2012 this sequence version replaced NP_011033.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..365 /product="RNA export factor GLE2" /calculated_mol_wt="40392" Region <36..333 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 39..78 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 84..119 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 124..163 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 170..204 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 211..250 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 272..298 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..365 /gene="GLE2" /locus_tag="YER107C" /gene_synonym="RAE1" /coded_by="NM_001178998.3:1..1098" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:8970155]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15210706]" /experiment="EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20098417|PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:8970155]" /experiment="EXISTENCE:mutant phenotype:GO:0032185 septin cytoskeleton organization [PMID:28776765]" /experiment="EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:9725905]" /experiment="EXISTENCE:mutant phenotype:GO:2000728 regulation of mRNA export from nucleus in response to heat stress [PMID:15210706]" /note="RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1" /db_xref="GeneID:856844" /db_xref="SGD:S000000909" ORIGIN 1 msffnrsntt salgtstama nekdlandiv inspaedsis diafspqqdf mfsasswdgk 61 vriwdvqngv pqgraqhess spvlctrwsn dgtkvasggc dnalklydia sgqtqqigmh 121 sapikvlrfv qcgpsnteci vtgswdktik ywdmrqpqpv stvmmpervy smdnkqsllv 181 vataerhiai inlanpttif kattsplkwq trcvacynea dgyaigsveg rcsiryiddg 241 mqkksgfsfk chrqtnpnra pgsngqslvy pvnsiafhpl ygtfvtaggd gtfnfwdknq 301 rhrlkgyptl qasipvcsfn rngsvfayal sydwhqghmg nrpdypnvir lhattdeevk 361 ekkkr // LOCUS NP_011035 1113 aa linear PLN 30-JUN-2025 DEFINITION karyopherin KAP123 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011035 VERSION NP_011035.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179000.1 REFERENCE 1 (residues 1 to 1113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1113) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07770. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1113 /product="karyopherin KAP123" /calculated_mol_wt="122471" Region 25..92 /region_name="IBN_N" /note="Importin-beta N-terminal domain; smart00913" /db_xref="CDD:197981" Region 40..65 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(57..58,61,64..65,100..101,104,107..108,111,139..140, 143,146..147,150,181..182,185,188..189) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 77..111 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 121..151 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 162..189 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(336,339..340,374..375,378,381..382,385,415..416,419, 422..423,426,460..461,464,467..468,500..501,504) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 352..385 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 397..427 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 438..468 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 479..506 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..1113 /gene="KAP123" /locus_tag="YER110C" /gene_synonym="YRB4" /coded_by="NM_001179000.1:1..3342" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247|PMID:9238021]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247|PMID:9238021]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:9321403]" /experiment="EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:11694505]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:9321403]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:11352936]" /experiment="EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:11694505]" /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:9321403]" /experiment="EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:22043304]" /experiment="EXISTENCE:physical interaction:GO:0061608 nuclear import signal receptor activity [PMID:9182759]" /note="Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1" /db_xref="GeneID:856846" /db_xref="SGD:S000000912" ORIGIN 1 mdqqflsqle qtlhaitsgv glkeatktlq tqfytqpttl palihilqng sddslkqlag 61 vearklvskh wnaidestra siktsllqta fsepkenvrh snarviasig teeldgnkwp 121 dlvpnliqta sgedvqtrqt aifilfslle dftsslsghi ddflalfsqt indpssleir 181 slsaqalnhv salieeqeti npvqaqkfaa sipsvvnvld avikaddtmn aklifnclnd 241 fllldsqltg nfivdlikls lqiavnseid edvrvfalqf iisslsyrks kvsqsklgpe 301 itvaalkvac eeidvddeln nedetgenee ntpsssairl lafasselpp sqvasviveh 361 ipamlqsanv ferraillai svavtgspdy ilsqfdkiip atinglkdte pivklaalkc 421 ihqlttdlqd evakfheeyl pliidiidsa kniviynyat valdgllefi aydaiakyld 481 plmnklfyml esnessklrc avvsaigsaa faagsafipy fktsvhylek fiqncsqieg 541 mseddielra ntfenistma ravrsdafae faeplvnsay eaiktdsarl resgyafian 601 lakvygenfa pflktilpei fktleldeyq fnfdgdaedl aafadsanee elqnkftvnt 661 gisyekevas aalselalgt kehflpyveq slkvlneqvd esyglretal ntiwnvvksv 721 llaskvepes ypkgipassy vnadvlaviq aaretsmgnl sdefetsmvi tvmedfanmi 781 kqfgaiiimd ngdssmleal cmqvlsvlkg thtcqtidie edvprdeeld aseteatlqd 841 valevlvsls qalagdfakv fdnfrpvvfg lfqsksknkr ssavgaasel algmkeqnpf 901 vhemlealvi rltsdkslev rgnaaygvgl lceyasmdis avyepvlkal yellsaadqk 961 alaaeddeat reiidrayan asgcvarmal knsalvpleq tvpallahlp lntgfeeynp 1021 ifelimklyq enspvitnet priieifsav ftkendrikl ekestlgree nmerlkqfqt 1081 eemkhkviel lkylnttyng ivaqnpvlaa via // LOCUS NP_011036 1093 aa linear PLN 30-JUN-2025 DEFINITION SBF complex DNA-binding subunit SWI4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011036 VERSION NP_011036.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179001.1 REFERENCE 1 (residues 1 to 1093) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1093) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1093) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1093) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1093) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1093) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1093) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1093) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1093) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07771. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1093 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1093 /product="SBF complex DNA-binding subunit SWI4" /calculated_mol_wt="123676" Region 52..123 /region_name="KilA-N" /note="KilA-N domain; pfam04383" /db_xref="CDD:367917" Region <509..>681 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 521..551 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(522,526..527,530..532,534..535,539,542,551,590,592, 596..597,612..614,616..617,623,632,639,641,643,647..648, 651..653,655..656,660,663,672) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 590..639 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 641..672 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..1093 /gene="SWI4" /locus_tag="YER111C" /gene_synonym="ART1" /coded_by="NM_001179001.1:1..3282" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0033309 SBF transcription complex [PMID:1832338|PMID:2689885|PMID:8423776]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:3542227|PMID:2649246]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:2649246|PMID:8423776]" /experiment="EXISTENCE:mutant phenotype:GO:0033309 SBF transcription complex [PMID:8423776]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20641022]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20641022|PMID:2649246|PMID:3542227]" /experiment="EXISTENCE:physical interaction:GO:0033309 SBF transcription complex [PMID:1465410]" /note="DNA binding component of the SBF complex (Swi4p-Swi6p); a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair; Slt2p-independent regulator of cold growth; acetylation at two sites, K1016 and K1066, regulates interaction with Swi6p" /db_xref="GeneID:856847" /db_xref="SGD:S000000913" ORIGIN 1 mpfdvlisnq kdntnhqnit pisksvllap hsnhpvieia tysetdvyec yirgfetkiv 61 mrrtkddwin itqvfkiaqf sktkrtkile kesndmqhek vqggygrfqg twipldsakf 121 lvnkyeiidp vvnsiltfqf dpnnpppkrs knsilrktsp gtkitspssy nktprkknss 181 sstsatttaa nkkgkknasi nqpnpsplqn lvfqtpqqfq vnssmnimnn ndnhttmnfn 241 ndtrhnlinn isnnsnqsti iqqqksihen sfnnnysatq kplqffpipt nlqnknvaln 301 npnnndsnsy shnidnvins snnnnngnnn nliivpdgpm qsqqqqqhhh eyltnnfnhs 361 mmdsitngns kkrrkklnqs neqqfynqqe kiqrhfklmk qpllwqsfqn pndhhneycd 421 sngsnnnnnt vasngssiev fssnendnsm nmssrsmtpf sagntssqnk lenkmtdqey 481 kqtiltilss erssdvdqal latlypapkn fninfeiddq ghtplhwata maniplikml 541 itlnanalqc nklgfncitk sifynncyke nafdeiisil kiclitpdvn grlpfhylie 601 lsvnksknpm iiksymdsii lslgqqdynl lkiclnyqdn igntplhlsa lnlnfevynr 661 lvylgastdi lnldnespas imnkfntpag gsnsrnnntk adrklarnlp qknyyqqqqq 721 qqqpqnnvki pkiiktqhpd kedstadvni aktdsevnes qylhsnqpns tnmntimedl 781 sninsfvtss vikdikstps kilenspily rrrsqsisde kekakdnenq vekkkdplns 841 vktampsles pssllpiqms plgkyskpls qqinklntkv sslqrimgee iknldnevve 901 tessisnnkk rlitiahqie dafdsvsnkt pinsisdlqs riketsskln sekqnfiqsl 961 eksqalklat ivqdeeskvd mntnssshpe kqedeepipk stsetsspkn tkadakfsnt 1021 vqesydvnet lrlateltil qfkrrmttlk iseakskins svkldkyrnl igitienids 1081 klddiekdlr ana // LOCUS NP_011037 187 aa linear PLN 30-JUN-2025 DEFINITION U6 snRNA complex subunit LSM4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011037 VERSION NP_011037.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179002.3 REFERENCE 1 (residues 1 to 187) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 187) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 187) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 187) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07772. On Jul 30, 2012 this sequence version replaced NP_011037.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..187 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..187 /product="U6 snRNA complex subunit LSM4" /calculated_mol_wt="21145" Region 2..87 /region_name="LSm4" /note="Like-Sm protein 4; cd01723" /db_xref="CDD:212470" Site order(7,10..11,16,18..20,23,25,30..33,36..37,39,68..80) /site_type="other" /note="putative oligomer interface [polypeptide binding]" /db_xref="CDD:212470" Site order(15..21,23..35,37..41) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212470" Site order(33,35,72) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:212470" Site 68..79 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212470" CDS 1..187 /gene="LSM4" /locus_tag="YER112W" /gene_synonym="SDB23; USS1" /coded_by="NM_001179002.3:1..564" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:18611963]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:10369684|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15075370]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:10369684]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]" /experiment="EXISTENCE:genetic interaction:GO:0033962 P-body assembly [PMID:17984320|PMID:18981231]" /experiment="EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970]" /experiment="EXISTENCE:mutant phenotype:GO:0017070 U6 snRNA binding [PMID:10369684]" /experiment="EXISTENCE:mutant phenotype:GO:0033962 P-body assembly [PMID:17984320|PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:physical interaction:GO:0005732 sno(s)RNA-containing ribonucleoprotein complex [PMID:15075370]" /note="Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:856848" /db_xref="SGD:S000000914" ORIGIN 1 mlplylltna kgqqmqielk ngeiiqgilt nvdnwmnltl snvteysees ainsednaes 61 skavklneiy irgtfikfik lqdniidkvk qqinsnnnsn sngpghkryy nnrdsnnnrg 121 nynrrnnnng nsnrrpysqn rqynnsnssn innsinsins nnqnmnnglg gsvqhhfnss 181 spqkvef // LOCUS NP_011038 706 aa linear PLN 30-JUN-2025 DEFINITION Tmn3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011038 VERSION NP_011038.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179003.3 REFERENCE 1 (residues 1 to 706) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 706) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 706) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 706) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07773. On Jul 30, 2012 this sequence version replaced NP_011038.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..706 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..706 /product="Tmn3p" /calculated_mol_wt="81415" Region 78..663 /region_name="EMP70" /note="Endomembrane protein 70; pfam02990" /db_xref="CDD:460774" CDS 1..706 /gene="TMN3" /locus_tag="YER113C" /coded_by="NM_001179003.3:1..2121" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006878 intracellular copper ion homeostasis [PMID:20681974]" /experiment="EXISTENCE:genetic interaction:GO:0007034 vacuolar transport [PMID:20526336]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:18178563]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:18178563]" /note="Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation" /db_xref="GeneID:856849" /db_xref="SGD:S000000915" ORIGIN 1 mrvrpkrsvi tlmaivvvml ilrnqfyssr trghgqepvi sssqknlydg witpnfyrkg 61 dplelivnkv esdltqlpya yydlpftcpp tmhkkplhls lneiirgdrk wesdyklkfg 121 ednpcetlca rkttkegmqt ldklvregyv vqwliddelp aattfisttd hkkyyasgfp 181 lgfidpdtdk tylhnhvmlv irfhasdndk ntivgfevyp rsvsdyhcpg asknyeqyei 241 vipedenelt ylpftysvyw reefevdwnh rwdyflnage lsdeqsiqfh wmslansvgi 301 vlsisfitli iyvrvmytdk snskspkymi niegietedd ldddkygkys vytvakdwiq 361 ngrpnlfglk vlillvsfgv qflftiigsl tiscsmnklh nvrnsvltma ilffvlgafm 421 asfvgtrlsm vtktkrtkan ylddnrylkd ykkfspifti lcgsslpgiv mvstfllnsi 481 vwahdstsal pfktivffms iyfivcipls lfggivanni plpqywlsgi tkdesnsdgn 541 glfvpksrak fnplvycgiy lcgifpllvi yvemqyvyks lwlekttfyy fygflflsii 601 llcvltmeis iigsyllmrf cfedkvvrnn wrwkcfemgf sggvymelys lyyifavlni 661 hgfssilisi cyslifnvmc slglgalsyl taswfinkiy hqkvnl // LOCUS NP_011039 1040 aa linear PLN 30-JUN-2025 DEFINITION Boi2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011039 VERSION NP_011039.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179004.1 REFERENCE 1 (residues 1 to 1040) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1040) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1040) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1040) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1040) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1040) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1040) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1040) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1040) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07774. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1040 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1040 /product="Boi2p" /calculated_mol_wt="115558" Region 47..101 /region_name="SH3_BOI" /note="Src Homology 3 domain of fungal BOI-like proteins; cd11886" /db_xref="CDD:212819" Site order(52,54,57,61,82..83,98,100..101) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212819" Region 264..328 /region_name="SAM_BOI-like_fungal" /note="SAM domain of BOI-like fungal subfamily; cd09535" /db_xref="CDD:188934" Region 770..886 /region_name="PH_Boi" /note="Boi family Pleckstrin homology domain; cd13316" /db_xref="CDD:270126" CDS 1..1040 /gene="BOI2" /locus_tag="YER114C" /gene_synonym="BEB1" /coded_by="NM_001179004.1:1..3123" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:28751498]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12097146]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12097146]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:12097146]" /experiment="EXISTENCE:genetic interaction:GO:0000920 septum digestion after cytokinesis [PMID:16615892]" /experiment="EXISTENCE:genetic interaction:GO:0007015 actin filament organization [PMID:31964708]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:17417630]" /experiment="EXISTENCE:mutant phenotype:GO:0099500 vesicle fusion to plasma membrane [PMID:28751498]" /note="Protein involved in polar growth; functionally redundant with Boi1p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth and for inhibition of membrane abscission until the end of cytokinesis; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI2 has a paralog, BOI1, that arose from the whole genome duplication" /db_xref="GeneID:856850" /db_xref="SGD:S000000916" ORIGIN 1 msndrevptl sqlnttvsrd kdvsdtlspd fdskgsatgr dggnfpmyia ineyfkrmed 61 eldmkpgdki kvitddeeyk dgwyfgrnlr tneeglypvv ftqkitveka ptlmrakstk 121 riyspltned pllsstfise ndsnselptp qpietaasis rtangkiern lslkntmsdi 181 dnallefkdd sigppdrfin sgrdeehsit hetilsatdg ldvvesnskp ttssstgfln 241 gdlenqatli ngidttklnp veaefwspee itayfimegy dvqsasrfqk hkisgkille 301 lelvhlkeld insfgtrfei fkeiekikea irtngrslnr asktnnaniy nqlmppanvd 361 qrasyrghvr ktsqsledlp sqqnfiptpr ntrnssaskh rpkslvfdsq eananiapdv 421 qipqvveema gnenlfvspr rapkppsyps paqppkspll nntrtspspa qlyswqsptl 481 sfsgpkrtsy idqysssdsn fnsrsalpkn nqgggkalsp ipsptrnsvr nedsegklts 541 sskrnsvpyy gyapesssdr ksscssheee qfqetmntfe rptssiyadg stiasisndk 601 lahekegkkk ptrhssslss ksksdsrrns slkrsssasr tssfkkssfm lspfrqqftd 661 naarssspee npitsmpsek nsspivdkks skksrskrrs vsakeaeift etvkddknkr 721 saseaikget lkgkslrqmt arpvakkkqt safieglrsi svkeamkdad fsgwmskkgs 781 gamstwktrf ftlhgtrlsy fssttdtrer gliditahrv vpakeddklv slyaastgkg 841 rycfkllppq pgskkgltft qprthyfavd nkeemrgwma alikttidid tsvpiissyt 901 tptvslskaq emlaeareet klreqqmlen eededqflwd qqqlqqqqhd nnqgqadrti 961 sastqrtsde dntistpnls sannttigsn gfsspfllas gllspgvarn ssmrgtekkg 1021 kfsteedyfg dnskhktdki // LOCUS NP_011040 191 aa linear PLN 30-JUN-2025 DEFINITION Spr6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011040 VERSION NP_011040.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179005.1 REFERENCE 1 (residues 1 to 191) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 191) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 191) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 191) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07775. Method: conceptual translation. FEATURES Location/Qualifiers source 1..191 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..191 /product="Spr6p" /calculated_mol_wt="21381" CDS 1..191 /gene="SPR6" /locus_tag="YER115C" /coded_by="NM_001179005.1:1..576" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24390141]" /experiment="EXISTENCE:expression pattern:GO:0030437 ascospore formation [PMID:2253272]" /note="hypothetical protein; expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation" /db_xref="GeneID:856851" /db_xref="SGD:S000000917" ORIGIN 1 mavsniwqsy sssnlhwiyp lytnncsqnv kssftaeill krrcndiqdi lndrmielll 61 qgacdpnkqq nylqgmspsr kkkthvkkfl kkqkksrkpi tlehgclsgp vtlrfgnfag 121 irdlrgtrcp lhgikhgvhp kpgercacqq atlfpsplar fscdqsavlg caasstrvyd 181 siadefssly f // LOCUS NP_011041 274 aa linear PLN 30-JUN-2025 DEFINITION SUMO-targeted ubiquitin ligase complex subunit SLX8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011041 VERSION NP_011041.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179006.3 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07776. On Jul 30, 2012 this sequence version replaced NP_011041.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..274 /product="SUMO-targeted ubiquitin ligase complex subunit SLX8" /EC_number="2.3.2.27" /calculated_mol_wt="30633" Region 1..264 /region_name="PEX10" /note="RING-finger-containing E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]; COG5574" /db_xref="CDD:227861" CDS 1..274 /gene="SLX8" /locus_tag="YER116C" /coded_by="NM_001179006.3:1..825" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:17848550|PMID:17728242|PMID:26906737|PMID:18032921]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:26906737|PMID:19270524]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:17728242|PMID:26906737|PMID:18032921|PMID:17848550]" /experiment="EXISTENCE:direct assay:GO:0033768 SUMO-targeted ubiquitin ligase complex [PMID:17848550]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:11139495]" /experiment="EXISTENCE:genetic interaction:GO:0016567 protein ubiquitination [PMID:26906737]" /experiment="EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:16387868]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:16428246]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:11139495|PMID:16325482]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:26906737]" /experiment="EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:16387868]" /note="Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; role in proteolysis of spindle positioning protein Kar9, DNA repair proteins Rad52p and Rad57p; stimulated by SUMO-modified substrates; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress; required for maintenance of genome integrity like human ortholog RNF4" /db_xref="GeneID:856852" /db_xref="SGD:S000000918" ORIGIN 1 marrpdnqnp egenlrikrv rlesvrqnde eeenevsrtq nivtdnrhds peavveiige 61 ralentseed gdddlslfra leedpgsdhn tsnndsgnhd retmhteepe assgnnitlt 121 nnveelhtmd vlsqtantps aspmldaapp ttkpgtnske qtvdltadai dldaeeqqvl 181 qisdddfqee tkeapkeyga akdyrcpicf eppetalmtl cghvfccpcl fqmvnssrtc 241 rqfghcalcr skvylkdvrl iilrkkqvkk kvks // LOCUS NP_011042 137 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL14 RPL23B [Saccharomyces cerevisiae S288C]. ACCESSION NP_011042 VERSION NP_011042.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179007.3 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07777. On Jul 30, 2012 this sequence version replaced NP_011042.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..137 /product="60S ribosomal protein uL14 RPL23B" /calculated_mol_wt="14342" Region 5..137 /region_name="PTZ00054" /note="60S ribosomal protein L23; Provisional" /db_xref="CDD:185418" CDS 1..137 /gene="RPL23B" /locus_tag="YER117W" /coded_by="NM_001179007.3:1..414" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L23B; homologous to mammalian ribosomal protein L23 and bacterial L14; RPL23B has a paralog, RPL23A, that arose from the whole genome duplication" /db_xref="GeneID:856853" /db_xref="SGD:S000000919" ORIGIN 1 msgngaqgtk frislglpvg aimncadnsg arnlyiiavk gsgsrlnrlp aaslgdmvma 61 tvkkgkpelr kkvmpaivvr qakswrrrdg vflyfednag vianpkgemk gsaitgpvgk 121 ecadlwprva snsgvvv // LOCUS NP_011043 367 aa linear PLN 30-JUN-2025 DEFINITION osmosensor SHO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011043 VERSION NP_011043.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179008.1 REFERENCE 1 (residues 1 to 367) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 367) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 367) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 367) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07778. Method: conceptual translation. FEATURES Location/Qualifiers source 1..367 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..367 /product="osmosensor SHO1" /calculated_mol_wt="40995" Region 304..358 /region_name="SH3_Sho1p" /note="Src homology 3 domain of High osmolarity signaling protein Sho1p; cd11855" /db_xref="CDD:212789" Site order(309,311,320,337..338,352..355) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212789" CDS 1..367 /gene="SHO1" /locus_tag="YER118C" /gene_synonym="SSU81" /coded_by="NM_001179008.1:1..1104" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10980703]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:10980703]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:10980703]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12374868]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0007231 osmosensory signaling pathway [PMID:7624781]" /experiment="EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:19439450]" /experiment="EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:9744864|PMID:18591427]" /experiment="EXISTENCE:mutant phenotype:GO:0005078 MAP-kinase scaffold activity [PMID:15200958]" /experiment="EXISTENCE:mutant phenotype:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:15200958]" /experiment="EXISTENCE:physical interaction:GO:0005034 osmosensor activity [PMID:7624781]" /experiment="EXISTENCE:physical interaction:GO:0005078 MAP-kinase scaffold activity [PMID:15200958|PMID:16778768]" /experiment="EXISTENCE:physical interaction:GO:0007231 osmosensory signaling pathway [PMID:7624781]" /experiment="EXISTENCE:physical interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:15200958|PMID:16778768]" /experiment="EXISTENCE:physical interaction:GO:0044697 HICS complex [PMID:22623719]" /note="Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol (HOG) response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p" /db_xref="GeneID:856854" /db_xref="SGD:S000000920" ORIGIN 1 msisskirpt prkpsrmatd hsfkmkkfya dpfaissisl aivswviaig gsissastne 61 sfprftwwgi vyqfliicsl mlfycfdlvd hyrifittsi avafvyntns atnlvyadgp 121 kkaaasagvi llsiinliwi lyyggdnasp tnrwidsfsi kgirpsplen slhrarrrgn 181 rnttpyqnnv yndairdsgy atqfdgypqq qpshtnyvss talagfentq pntseavnlh 241 lntlqqrins asnaketndn snnqtntnig ntfdtdfsng ntettmgdtl glysdigddn 301 fiykakalyp ydaddddaye isfeqneilq vsdiegrwwk arrangetgi ipsnyvqlid 361 gpeemhr // LOCUS NP_011044 448 aa linear PLN 30-JUN-2025 DEFINITION aspartate/glutamate transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_011044 VERSION NP_011044.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179009.1 REFERENCE 1 (residues 1 to 448) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 448) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 448) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 448) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07779. Method: conceptual translation. FEATURES Location/Qualifiers source 1..448 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..448 /product="aspartate/glutamate transporter" /calculated_mol_wt="48709" Region 1..439 /region_name="Aa_trans" /note="Transmembrane amino acid transporter protein; pfam01490" /db_xref="CDD:279788" CDS 1..448 /gene="AVT6" /locus_tag="YER119C" /coded_by="NM_001179009.1:1..1347" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11274162]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:20118605]" /experiment="EXISTENCE:mutant phenotype:GO:0005313 L-glutamate transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015183 L-aspartate transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:11274162]" /note="Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication" /db_xref="GeneID:856855" /db_xref="SGD:S000000921" ORIGIN 1 mvasirsgvl tllhtacgag ilampyafkp fglipgvimi vlcgacamqs lfiqarvaky 61 vpqgrasfsa ltrlinpnlg ivfdlaiaik cfgvgvsymi vvgdlmpqim svwtrnawll 121 nrnvqislim lffvaplsfl kklnslryas mvaissvayl cvlvllhyva psdeilrlkg 181 risyllppqs hdlnvlntlp ifvfaytchh nmfsiineqr ssrfehvmki pliaislali 241 lyiaigcagy ltfgdniign iimlypqavs stigriaivl lvmlafplqc hparasihqi 301 lqhfaeenvs isatsadept vatessplir dssldlnevi eeesiyqpke tplrgksfiv 361 itcsilvasy lvaisvssla rvlaivgatg stsisfilpg lfgykligte hktavplttk 421 ifkytglllf iwgliimitc ltaalkln // LOCUS NP_011046 244 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol-binding protein SCS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011046 VERSION NP_011046.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179010.3 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07780. On Jul 30, 2012 this sequence version replaced NP_011046.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..244 /product="phosphatidylinositol-binding protein SCS2" /calculated_mol_wt="26795" Region 2..244 /region_name="SCS2" /note="VAMP-associated protein involved in inositol metabolism [Intracellular trafficking and secretion]; COG5066" /db_xref="CDD:227398" CDS 1..244 /gene="SCS2" /locus_tag="YER120W" /coded_by="NM_001179010.3:1..735" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:25420878|PMID:12727870]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12727870|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9537365]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25420878]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17984322]" /experiment="EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:9537365]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:17963691]" /experiment="EXISTENCE:direct assay:GO:0061163 endoplasmic reticulum polarization [PMID:25083872]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:25420878]" /experiment="EXISTENCE:genetic interaction:GO:0008654 phospholipid biosynthetic process [PMID:8537323]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:11333225|PMID:12399377]" /experiment="EXISTENCE:genetic interaction:GO:0048309 endoplasmic reticulum inheritance [PMID:17984322]" /experiment="EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:9537365|PMID:12761300]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11333225]" /experiment="EXISTENCE:mutant phenotype:GO:0032377 regulation of intracellular lipid transport [PMID:12727870]" /experiment="EXISTENCE:mutant phenotype:GO:0033149 FFAT motif binding [PMID:12727870]" /experiment="EXISTENCE:mutant phenotype:GO:0042308 negative regulation of protein import into nucleus [PMID:12727870]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:17984322]" /experiment="EXISTENCE:physical interaction:GO:0005935 cellular bud neck [PMID:25083872]" /experiment="EXISTENCE:physical interaction:GO:0033149 FFAT motif binding [PMID:12727870]" /experiment="EXISTENCE:physical interaction:GO:0042308 negative regulation of protein import into nucleus [PMID:12727870]" /note="Integral ER membrane protein, regulates phospholipid metabolism; one of 6 proteins (Ist2p, Scs2p, Scs22p, Tcb1p, Tcb2p, Tcb3p) that connect the ER to the plasma membrane (PM); regulates PI4P levels by controlling access of Sac1p to PM substrate PI4P; interacts with FFAT motifs in Opi1p, Swh1p, Osh2p and Osh3p; role in NVJ integrity and micronucleophagy; role in telomeric silencing; VAMP-associated protein (VAP) homolog; SCS2 has a paralog, SCS22, that arose from the whole genome duplication" /db_xref="GeneID:856856" /db_xref="SGD:S000000922" ORIGIN 1 msaveispdv lvyksplteq steyasisnn sdqtiafkvk ttapkfycvr pnaavvapge 61 tiqvqviflg lteepaadfk crdkflvitl pspydlngka vadvwsdlea efkqqaiskk 121 ikvkylispd vhpaqnqniq enketvepvv qdsepkevpa vvnekevpae petqppvqvk 181 keevppvvqk tvphenekqt snstpapqnq ikeaatvpae nesssmgifi lvallilvlg 241 wfyr // LOCUS NP_011047 114 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER121W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011047 VERSION NP_011047.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179011.3 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07781. On Jul 30, 2012 this sequence version replaced NP_011047.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..114 /product="uncharacterized protein" /calculated_mol_wt="12810" CDS 1..114 /locus_tag="YER121W" /coded_by="NM_001179011.3:1..345" /note="hypothetical protein; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy" /db_xref="GeneID:856858" /db_xref="SGD:S000000923" ORIGIN 1 mglsrwhdkn srpaeeksee mqqdahyyal aasdslnasv sneygnqvmn sfwkvgidsp 61 yvddeairnr dvennlpslk qsvynanepn atssafstas yahetfdfrn lklr // LOCUS NP_011048 493 aa linear PLN 30-JUN-2025 DEFINITION ADP-ribosylation factor GTPase-activating protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011048 VERSION NP_011048.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179012.1 REFERENCE 1 (residues 1 to 493) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 493) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 493) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 493) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07782. Method: conceptual translation. FEATURES Location/Qualifiers source 1..493 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..493 /product="ADP-ribosylation factor GTPase-activating protein" /calculated_mol_wt="54963" Region 9..363 /region_name="COG5347" /note="GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]" /db_xref="CDD:227651" CDS 1..493 /gene="GLO3" /locus_tag="YER122C" /coded_by="NM_001179012.1:1..1482" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:9927415]" /experiment="EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9927415]" /experiment="EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:15254269]" /experiment="EXISTENCE:direct assay:GO:0048205 COPI coating of Golgi vesicle [PMID:15254269]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9927415]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9927415]" /experiment="EXISTENCE:mutant phenotype:GO:0048205 COPI coating of Golgi vesicle [PMID:15254269]" /experiment="EXISTENCE:physical interaction:GO:0030126 COPI vesicle coat [PMID:15254269]" /note="ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; shares functional similarity with Gcs1p" /db_xref="GeneID:856859" /db_xref="SGD:S000000924" ORIGIN 1 msndegetfa teqttqqvfq klgsnmenrv cfdcgnknpt wtsvpfgvml ciqcsavhrn 61 mgvhitfvks stldkwtinn lrrfklggnh kardfflknn gkqllntanv daktkytspv 121 akkykihldk kvqkdmelyp selvlngqds sdspldtdsd asrstskens vddffsnwqk 181 pssnssskln vntgslapkn nttgstpktt vtktrssilt asrkkpvlns qdkkkhsils 241 ssrkptrlta kkvdksqaed lfdqfkkeaq qekedeftns ssstkirqnd ydsqfmnnsk 301 gnnnnsiddi ntqpdefndf lndtsnsfdt trkeqqdtlt pkfaklgfgm tmndandlak 361 qqkesqkiaq gprytgriae rygtqkaiss dqlfgrgsfd eaanreahdk lktfdnatsi 421 ssssyfgedk evdefgnpin ssgsgagnfd grnsnngfid fnasaddelq mlrdvveqga 481 eklgsylrdy lrk // LOCUS NP_011049 524 aa linear PLN 30-JUN-2025 DEFINITION casein kinase YCK3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011049 VERSION NP_011049.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179013.1 REFERENCE 1 (residues 1 to 524) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 524) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 524) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 524) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07783. On Mar 22, 2000 this sequence version replaced NP_011049.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..524 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..524 /product="casein kinase YCK3" /EC_number="2.7.11.1" /calculated_mol_wt="60130" Region 13..320 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(20..23,26,28,58,60,88,104..107,150,154..155,157, 188..189) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" Region 361..>479 /region_name="ROM1" /note="RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]; COG5422" /db_xref="CDD:227709" CDS 1..524 /gene="YCK3" /locus_tag="YER123W" /gene_synonym="CKI3" /coded_by="NM_001179013.1:1..1575" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16301533]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14668479|PMID:26928762|PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8816449]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8816449]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:19116312]" /note="Palmitoylated vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; targeted to vacuole via AP-3 pathway; regulates vesicle fusion in AP-3 pathway" /db_xref="GeneID:856860" /db_xref="SGD:S000000925" ORIGIN 1 msqrssqhiv gihyavgpki gegsfgvife genilhscqa qtgskrdssi imanepvaik 61 feprhsdapq lrdefrayri lngcvgipha yyfgqegmhn iliidllgps ledlfewcgr 121 kfsvkttcmv akqmidrvra ihdhdliyrd ikpdnflisq yqrispegkv ikscasssnn 181 dpnliymvdf gmakqyrdpr tkqhipyrer kslsgtarym sinthfgreq srrddleslg 241 hvffyflrgs lpwqglkapn nklkyekigm tkqklnpddl llnnaipyqf atylkyarsl 301 kfdedpdydy lislmddalr lndlkddghy dwmdlnggkg wnikinrran lhgygnpnpr 361 vngntarnnv ntnsktrntt pvatpkqqaq nsynkdnsks rissnpqsft kqqhvlkkie 421 pnskyipeth snlqrpiksq sqtydsisht qnspfvpyss skanpkrsnn ehnlpnhytn 481 lankninyqs qrnyeqenda ysddendtfc skiykycccc fccc // LOCUS NP_011050 573 aa linear PLN 30-JUN-2025 DEFINITION Dse1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011050 VERSION NP_011050.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179014.3 REFERENCE 1 (residues 1 to 573) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 573) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 573) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 573) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07784. On Jul 30, 2012 this sequence version replaced NP_011050.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..573 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..573 /product="Dse1p" /calculated_mol_wt="63868" Region 217..252 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 257..301 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 320..354 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 361..394 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..573 /gene="DSE1" /locus_tag="YER124C" /coded_by="NM_001179014.3:1..1722" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031683 G-protein beta/gamma-subunit complex binding [PMID:19820940]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:11309124]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:19820940]" /experiment="EXISTENCE:mutant phenotype:GO:0010969 regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:19820940]" /note="Daughter cell-specific protein; may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall; relocalizes from bud neck to cytoplasm upon DNA replication stress" /db_xref="GeneID:856861" /db_xref="SGD:S000000926" ORIGIN 1 mqdtkyyept nifrqpaini kkrsdkkril qsmmtlstyk ktwqnntskm nspilrkasd 61 nfndyyttkk lksdywklyg vdeselsips dmsivdnill vstmnekdnl klfeisaekk 121 lkelqtitvp gkpitcicll pmvdfppqif pssqinpnhn qliltghqdg ivnliatsty 181 kgcakiikrf nhnkflkstv stsipileit pktapilkvs pwnktgfvsl lndslfiydl 241 ksnldciktp iflqsypgin sfavnefhdp fllalvgskf gpngislldl rtnlyipdil 301 dnsisagcgk dhlqrkntsl dcvwisnhhv aqslndkiqi wdiqscdgkp vcelyakkgy 361 ieslkfnent galyssddqg fvicwdlqnl qnmkygelvh gfnsisldse sellltkqvf 421 qcgniivsgm sdkniclksn dtkangkgcg flfldmandg slvtldnfce lglhqicqvq 481 fnvdtgkiid gngtgksgis dssmlslsne sdhsmtetsd dmfsnsgnwd cssantvseg 541 rlnddqediv ftkrmysvnd vhlsgstidt tvv // LOCUS NP_011051 809 aa linear PLN 30-JUN-2025 DEFINITION NEDD4 family E3 ubiquitin-protein ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011051 VERSION NP_011051.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179015.3 REFERENCE 1 (residues 1 to 809) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 809) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 809) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 809) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07785. On Jul 30, 2012 this sequence version replaced NP_011051.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..809 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..809 /product="NEDD4 family E3 ubiquitin-protein ligase" /EC_number="2.3.2.26" /calculated_mol_wt="91685" Region 3..809 /region_name="HUL4" /note="Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; COG5021" /db_xref="CDD:227354" CDS 1..809 /gene="RSP5" /locus_tag="YER125W" /gene_synonym="HPG1; MDP1; MUT2; NPI1; SMM1; UBY1" /coded_by="NM_001179015.3:1..2430" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:9108033|PMID:23443663|PMID:21685393|PMID:27694912]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14608372]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15078904|PMID:14657247]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14657247]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:14608372]" /experiment="EXISTENCE:direct assay:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:30361468]" /experiment="EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:14657247]" /experiment="EXISTENCE:direct assay:GO:0010994 free ubiquitin chain polymerization [PMID:19153599]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:23443663]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0034450 ubiquitin-ubiquitin ligase activity [PMID:19153599]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:15078904]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:19252184]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0070534 protein K63-linked ubiquitination [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0070651 nonfunctional rRNA decay [PMID:30893611]" /experiment="EXISTENCE:genetic interaction:GO:0006808 regulation of nitrogen utilization [PMID:15247235]" /experiment="EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:10366593]" /experiment="EXISTENCE:genetic interaction:GO:0010794 regulation of dolichol biosynthetic process [PMID:18771750]" /experiment="EXISTENCE:genetic interaction:GO:0010795 regulation of ubiquinone biosynthetic process [PMID:18771750]" /experiment="EXISTENCE:genetic interaction:GO:0019220 regulation of phosphate metabolic process [PMID:18165238]" /experiment="EXISTENCE:genetic interaction:GO:0032443 regulation of ergosterol biosynthetic process [PMID:18771750]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:15855235]" /experiment="EXISTENCE:genetic interaction:GO:0034517 ribophagy [PMID:18670191]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:27694912|PMID:21685393|PMID:9108033]" /experiment="EXISTENCE:mutant phenotype:GO:0005829 cytosol [PMID:25344756]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:12399376]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9614172|PMID:25344756]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:10366593]" /experiment="EXISTENCE:mutant phenotype:GO:0010793 regulation of mRNA export from nucleus [PMID:14608372]" /experiment="EXISTENCE:mutant phenotype:GO:0010794 regulation of dolichol biosynthetic process [PMID:18771750]" /experiment="EXISTENCE:mutant phenotype:GO:0010795 regulation of ubiquinone biosynthetic process [PMID:18771750]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:29444958]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:27385342]" /experiment="EXISTENCE:mutant phenotype:GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [PMID:24962567]" /experiment="EXISTENCE:mutant phenotype:GO:0032443 regulation of ergosterol biosynthetic process [PMID:18771750]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17182849]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:12867034]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:31658248]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:25344756|PMID:24962567]" /experiment="EXISTENCE:mutant phenotype:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:17344478]" /experiment="EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:29444958]" /experiment="EXISTENCE:mutant phenotype:GO:0045723 positive regulation of fatty acid biosynthetic process [PMID:11007476]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:12654912]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11007476]" /experiment="EXISTENCE:mutant phenotype:GO:0048260 positive regulation of receptor-mediated endocytosis [PMID:11179425]" /experiment="EXISTENCE:mutant phenotype:GO:0070086 ubiquitin-dependent endocytosis [PMID:17344478|PMID:31658248|PMID:32800549]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:31658248]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:21070972]" /experiment="EXISTENCE:mutant phenotype:GO:1903577 cellular response to L-arginine [PMID:32800549]" /experiment="EXISTENCE:mutant phenotype:GO:2000203 regulation of ribosomal large subunit export from nucleus [PMID:14608372]" /experiment="EXISTENCE:mutant phenotype:GO:2000232 regulation of rRNA processing [PMID:14608372]" /experiment="EXISTENCE:mutant phenotype:GO:2000235 regulation of tRNA processing [PMID:14608372]" /experiment="EXISTENCE:mutant phenotype:GO:2000238 regulation of tRNA export from nucleus [PMID:14608372]" /experiment="EXISTENCE:physical interaction:GO:0000151 ubiquitin ligase complex [PMID:9931424]" /experiment="EXISTENCE:physical interaction:GO:0010793 regulation of mRNA export from nucleus [PMID:15713680]" /experiment="EXISTENCE:physical interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17182849]" /experiment="EXISTENCE:physical interaction:GO:0032880 regulation of protein localization [PMID:12867034]" /experiment="EXISTENCE:physical interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:15713680]" /note="NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p, Sem1p, Dip5p and Put4p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome" /db_xref="GeneID:856862" /db_xref="SGD:S000000927" ORIGIN 1 mpssisvklv aaeslykrdv frspdpfavl tidgyqtkst saakktlnpy wnetfkfddi 61 nensiltiqv fdqkkfkkkd qgflgvvnvr vgdvlghlde dtatssgrpr eetitrdlkk 121 sndgmavsgr livvlsklps ssphsqapsg htassstnts sttrtnghst sstrnhstsh 181 psrgtaqave stlqsgttaa tntattshrs tnstssatrq yssfedqygr lppgwerrtd 241 nfgrtyyvdh ntrtttwkrp tldqteaerg nqlnantele rrqhrgrtlp ggssdnssvt 301 vqvgggsnip pvngaaaaaf aatggttsgl gelpsgweqr ftpegrayfv dhntrtttwv 361 dprrqqyirt ygptnttiqq qpvsqlgplp sgwemrltnt arvyfvdhnt ktttwddprl 421 pssldqnvpq ykrdfrrkvi yfrsqpalri lpgqchikvr rknifedayq eimrqtpedl 481 kkrlmikfdg eegldyggvs refffllshe mfnpfyclfe ysaydnytiq inpnsginpe 541 hlnyfkfigr vvglgvfhrr fldaffvgal ykmmlrkkvv lqdmegvdae vynslnwmle 601 nsidgvldlt fsadderfge vvtvdlkpdg rnievtdgnk keyvelytqw rivdrvqeqf 661 kafmdgfnel ipedlvtvfd erelelligg iaeidiedwk khtdyrgyqe sdeviqwfwk 721 cvsewdneqr arllqfttgt sripvngfkd lqgsdgprrf tiekagevqq lpkshtcfnr 781 vdlpqyvdyd smkqkltlav eetigfgqe // LOCUS NP_011052 261 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein NSA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011052 VERSION NP_011052.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179016.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07786. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..261 /product="rRNA-processing protein NSA2" /calculated_mol_wt="29592" Region 4..261 /region_name="NSA2" /note="pre-ribosomal protein NSA2 (Nop seven-associated 2); cd11381" /db_xref="CDD:211393" CDS 1..261 /gene="NSA2" /locus_tag="YER126C" /coded_by="NM_001179016.1:1..786" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:16861225|PMID:11583614]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16861225]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16861225]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]" /note="Protein constituent of 66S pre-ribosomal particles; contributes to processing of the 27S pre-rRNA; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2" /db_xref="GeneID:856863" /db_xref="SGD:S000000928" ORIGIN 1 mpqndyierh ikqhgkrldh eerkrkrear eshkiseraq kltgwkgkqf akkryaekvs 61 mrkkikaheq skvkgsskpl dtdgdalpty lldreqnnta kaisssikqk rlekadkfsv 121 plpkvrgise eemfkviktg ksrskswkrm itkhtfvgeg ftrrpvkmer iirpsalrqk 181 kanvthpelg vtvflpilav kknpqspmyt qlgvltkgti ievnvselgm vtaggkvvwg 241 kyaqvtnepd rdgcvnavll v // LOCUS NP_011053 357 aa linear PLN 30-JUN-2025 DEFINITION small subunit rRNA maturation protein LCP5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011053 VERSION NP_011053.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179017.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07787. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..357 /product="small subunit rRNA maturation protein LCP5" /calculated_mol_wt="40663" Region 8..108 /region_name="Sas10_Utp3" /note="Sas10/Utp3/C1D family; pfam04000" /db_xref="CDD:461123" CDS 1..357 /gene="LCP5" /locus_tag="YER127W" /coded_by="NM_001179017.1:1..1074" /note="Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus" /db_xref="GeneID:856864" /db_xref="SGD:S000000929" ORIGIN 1 mselnallkd ingsltatse slerlsgiys nsatdeipes nqlhehlfyd akkpaekvsl 61 lslkngsmlg yinsllmlig nrlddeckdp samdarersi qhrvvlergv kplekklayq 121 ldkltrayvk mekeykdaek ralekstlvn hsgnddsedd essedeiayr pntsgiintn 181 kkssayrvee takqengeen ddnetgvykp pkitavlppq qthfedrfda rehkdrsnks 241 rmqameeyir essdqpdwsa sigadivnhg rggikslrdt ekerrvtsfe ednftrlnit 301 nkaekrkqkq rernarmnvi ggedfgifss krkledstsr rgakktrsaw draqrrl // LOCUS NP_011054 203 aa linear PLN 30-JUN-2025 DEFINITION Vfa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011054 VERSION NP_011054.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179018.3 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07788. On Jul 30, 2012 this sequence version replaced NP_011054.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..203 /product="Vfa1p" /calculated_mol_wt="23358" Region 3..203 /region_name="Vfa1" /note="AAA-ATPase Vps4-associated protein 1; pfam08432" /db_xref="CDD:429993" CDS 1..203 /gene="VFA1" /locus_tag="YER128W" /coded_by="NM_001179018.3:1..612" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:24567329]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21777356]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:21777356]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:21777356]" /note="Protein that interacts with Vps4p and has a role in vacuolar sorting; stimulates the ATPase activity of Vps4; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology" /db_xref="GeneID:856865" /db_xref="SGD:S000000930" ORIGIN 1 mineyvarkv alkdmqpcai cskpsttvly nasgpdwlyt ceihlqdnpq fviplystey 61 neavaqlklv kgkmdsltsa qtqlgswdgw vtkifskkek etnnskdpdp tttdstdtsp 121 qakndaeils etkkqyskil dkvtelqrkn rkyelakimf esrllrkrte qvnrerylke 181 qenysntdpe ellrkhvfps vpk // LOCUS NP_011055 1142 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase SAK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011055 VERSION NP_011055.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179019.3 REFERENCE 1 (residues 1 to 1142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1142) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07789. On Jul 30, 2012 this sequence version replaced NP_011055.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1142 /product="serine/threonine protein kinase SAK1" /EC_number="2.7.11.1" /calculated_mol_wt="126742" Region 139..448 /region_name="STKc_LKB1_CaMKK" /note="Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins; cd14008" /db_xref="CDD:270910" Site order(139..143,147,160,162,205,223..226,230,232,277,279, 281..282,284,295,298,324..327) /site_type="active" /db_xref="CDD:270910" Site order(139..143,147,160,162,205,223..226,230,277,279, 281..282,284,295) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270910" Site order(143,230,232,277,279,281,298,324..327) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270910" Site order(294..302,313,321..327) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270910" CDS 1..1142 /gene="SAK1" /locus_tag="YER129W" /gene_synonym="PAK1" /coded_by="NM_001179019.3:1..3429" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:27524664|PMID:16201971|PMID:12748292|PMID:12847291]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22289182|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0090329 regulation of DNA-templated DNA replication [PMID:9341678]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:16201971|PMID:12748292]" /experiment="EXISTENCE:mutant phenotype:GO:0005979 regulation of glycogen biosynthetic process [PMID:15340085]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:15340085]" /experiment="EXISTENCE:mutant phenotype:GO:1900180 regulation of protein localization to nucleus [PMID:15340085]" /experiment="EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:19880754]" /note="Upstream serine/threonine kinase for the SNF1 complex; plays a role in pseudohyphal growth; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; SAK1 has a paralog, TOS3, that arose from the whole genome duplication" /db_xref="GeneID:856866" /db_xref="SGD:S000000931" ORIGIN 1 mdrsdkkvnv eevnvpsnlq ieleksgtss svslrsptks satnlagmae gardnasias 61 ssvdslnmll erqrvrqlnh pqhqqhisss laktptttss fcssgssknk vketnrislt 121 ydpvskrkvl ntyeiikelg hgqhgkvkla rdilskqlva ikivdrhekk qrkfftfiks 181 skisendkik reiaimkkch hkhvvqliev lddlksrkiy lvleycsrge vkwcppdcme 241 sdakgpslls fqetreilrg vvlgleylhy qgiihrdikp anllisgdgt vkisdfgvsl 301 aasstnssds sesldelela ktvgtpaffa pemclgedaf trynltkenl frgscisfmi 361 diwavgvtly cllfgmlpff sdfelklfek ivndplkfpt fkeiqsnkvs kvsceeeyem 421 akdlllklle knpqkrmtip aikkhpfvsw dfdhvpende kllssvleqk lrfqcnqtdq 481 fepisiskhe lknavsgvgk kikesvlksi plkdpsdlsn knylhptett rgrgdanviv 541 segsvlsnik elsandgcln tdsdtninin dddhysgddn dghltkrele relnkfddkh 601 eagnmvnlpi nssfasldsf yidnfamarm gmsspeagds vssvpnlpsa psstrlgrsp 661 vfsgvtnqps pirpvlpqqk ssfcatgryd kshnsllrns sshltsynsg rpssrtgrmn 721 srnqnlpkip nslskisttk ltelrvpkds eipspaknpn adrlrrfpvk kntktpaikd 781 pprininssd ksgsknspik slyqrmkqsk dnsktfevrr gnffshfngd dddsssqssv 841 tssgsesdse lsstssscts gtqsrnssnn nayseteslp fefgvdsedg sgvllrdlpn 901 edqirpfldi qpcrrmkvks slnleppsvs sssssssded elilnvgtag hrrrhnsskl 961 selsnspqkg snnfmysngs vhdsettitp qnmddltlhq alsrsqpisk pgplvlpkrl 1021 dqkkattets nltdivefng nndhrkdknf dkvlysrdll kdalsstnag rrrsipsnki 1081 rgrkdasitm stnvgndeha rntschgdkg qengaikqrt hersrsltva elneekrrsa 1141 lp // LOCUS NP_011056 443 aa linear PLN 30-JUN-2025 DEFINITION Com2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011056 VERSION NP_011056.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179020.1 REFERENCE 1 (residues 1 to 443) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 443) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 443) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 443) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07790. Method: conceptual translation. FEATURES Location/Qualifiers source 1..443 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..443 /product="Com2p" /calculated_mol_wt="50189" Region 1..443 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 391..412 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 420..440 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..443 /gene="COM2" /locus_tag="YER130C" /coded_by="NM_001179020.1:1..1332" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:24236068]" /experiment="EXISTENCE:mutant phenotype:GO:0071252 cellular response to sulfur dioxide [PMID:31799324]" /experiment="EXISTENCE:mutant phenotype:GO:0080135 regulation of cellular response to stress [PMID:31799324]" /note="Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA; C. albicans homolog (MNL1) plays a role in adaptation to stress" /db_xref="GeneID:856867" /db_xref="SGD:S000000932" ORIGIN 1 mslyplqrfe sndtvfsytl nsktelfnes rnndkqhftl qlipnanana keidnnnvei 61 indltgntiv dncvttatss nqlerrlsis dyrtengnyy eyeffgrrel neplfnndiv 121 endddidlnn esdvlmvsdd elevnerfsf lkqqpldgln risstnnlkn leihefiidp 181 teniddeled sfttvpqskk kvrdyfklni fgsssssnnn snslgcepiq tensssqkmf 241 knrffrsrks tlikslpleq enevlinsgf dvssneesde sdhaiinplk lvgnnkdist 301 qsiakttnpf ksgsdfkmie pvskfsndsr kdllaaisep ssspspsaps psvqsssssh 361 glvvrkktgs mqktrgrkps lipdaskqfg cefcdrrfkr qehlkrhvrs lhmcekpftc 421 hicnknfsrs dnlnqhvkth asl // LOCUS NP_011057 119 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS26 RPS26B [Saccharomyces cerevisiae S288C]. ACCESSION NP_011057 VERSION NP_011057.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179021.1 REFERENCE 1 (residues 1 to 119) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 119) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 119) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 119) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07791. Method: conceptual translation. FEATURES Location/Qualifiers source 1..119 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..119 /product="40S ribosomal protein eS26 RPS26B" /calculated_mol_wt="13316" Region 1..104 /region_name="Ribosomal_S26e" /note="Ribosomal protein S26e; pfam01283" /db_xref="CDD:426179" CDS 1..119 /gene="RPS26B" /locus_tag="YER131W" /coded_by="NM_001179021.1:1..360" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:25144938]" /experiment="EXISTENCE:mutant phenotype:GO:0042255 ribosome assembly [PMID:27303706]" /experiment="EXISTENCE:physical interaction:GO:0030686 90S preribosome [PMID:25144938]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26B has a paralog, RPS26A, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia" /db_xref="GeneID:856868" /db_xref="SGD:S000000933" ORIGIN 1 mpkkrasngr nkkgrghvkp vrcvncsksi pkdkaikrma irniveaaav rdlseasvyp 61 eyalpktynk lhycvscaih arivrvrsre drknrappqr prfnrdnkvs paaaakkal // LOCUS NP_011058 1753 aa linear PLN 30-JUN-2025 DEFINITION Pmd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011058 VERSION NP_011058.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179022.3 REFERENCE 1 (residues 1 to 1753) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1753) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1753) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1753) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07792. On Jul 30, 2012 this sequence version replaced NP_011058.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1753 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1753 /product="Pmd1p" /calculated_mol_wt="195253" Region 132..188 /region_name="Kelch_6" /note="Kelch motif; pfam13964" /db_xref="CDD:404790" Region 132..184 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 188..235 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" CDS 1..1753 /gene="PMD1" /locus_tag="YER132C" /coded_by="NM_001179022.3:1..5262" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0030437 ascospore formation [PMID:9383076]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:9383076]" /note="Protein with an N-terminal kelch-like domain; putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions; PMD1 has a paralog, MDS3, that arose from the whole genome duplication" /db_xref="GeneID:856869" /db_xref="SGD:S000000934" ORIGIN 1 mtvlqppssv cyplnlpivp npnldeatrk kltlecrtga avelarsgvf vhggltlpln 61 ltiinslqlq kelilyfgkq kdrnadfktl adwispeiff ldlisrtwqr inttidttse 121 nelnnglsfk erlfhsmcft esniyifggl mvsphngyel iatnelwkld lktkcwslis 181 enpqitrrfn hsmhvlnenn enqdtkliiv ggldnmdipv kkidifnlrt slwesesksd 241 enpaskgssk ilvnidgmpi slshdsnfsv liennqaeip tlalyypqre antsrrgtdd 301 gsfstyahdl ddksklpkhh hhhhgdlkyf esddadenav ktlmspivil pllgnsqgar 361 mtsnptqnnk ensilqvpfh lqypsgnyfn ynivvigfyp dpqpsnlhcf iyniasgkwi 421 rvniactecs ismhrfwkll iwkshhqall lgtrtddfcs psvqkfdhil sfslpmlngy 481 nklvntkhtr tnngianshn lnvnlslydh lpysnsstie htnpytvtqg yslddsgipr 541 ltstatsqfe nysryitvpl emestssifp pyamvlgkda leifgktlsd fefitadgds 601 igvpvyllrk rwgryfdsll sngyantsfn yefngdtsni isfsphtask ttkfgnssqs 661 sngslekyfs kngnsksnsn tslkkphsvd ftsstsspkq raishnklsp sepilcadee 721 dsrsntlkqh atgdtglket gtsnkrpist tcsstgmvfr vpfqdmknsk lglseqsgrs 781 trassvsppp vykkstndgn dsnctlsntp lvyrrastvg tttnssvddg fssirrashp 841 lqsyiiakss pssiskaspa ekafsrrkss alrfiaspnq srqtsfasta stasvvssts 901 grrrnsnqis hlgssaslpn spilpvlnip lppqekiple plppvpkaps rrssslaeyv 961 qfgrdspvas rrsshstrks sssdarrisn ssllrntlds qllsnsygsd ipyeasiqey 1021 gmnngrdeee dgdnqdygci spsnirpifs tinainingn fkegeffssk syinneksrr 1081 lsyisnpesv estnsnnnai ieleplltpr slympwstas vrafaeffyt aqingkwlla 1141 pvtldllima kiyeipilye litevlykii skkeeglsvt ceallnlfqq kvsrycnene 1201 gkirkqldss esyqdtleik rslanidngy vdsyllrnts maqsihytdd sngeteidmh 1261 htgissigsl anravptvfa ggprdshnsi gsiafpsnsg vqnirrsvsl fspatkkkss 1321 lsretdpldt sdqftddvpd sgpvsrqqnf prrsssftet vpteptryny qnldssksnr 1381 asddkeeqne qatlqdisnf dkykvetlqk rnsndgkdld rtndplknrg teipqnssnl 1441 etdpfirdsf dsdsgssfrs dsddldsqlg ilpftkmnkk lqeqtsqefd dsidplykig 1501 sstpgssrlh gsfskyirpn sqredgseyv nisslenmvs pnalppvdyv mksiyrtsvl 1561 vndsnlmtrt keaielskvl kklkkkvlqd isqmddemre tgkpifargs ssptlsrqhs 1621 dvatplkqqe ntrpalkfas sspisegfrk ssikfsqaps tqisprtsvt dftasqqrrq 1681 hmnkrfstqt thstsalfmn pafmpsavnt grkeseghce drsatanrtn rkedattndn 1741 dniapfpffg krr // LOCUS NP_011059 312 aa linear PLN 30-JUN-2025 DEFINITION type 1 serine/threonine-protein phosphatase catalytic subunit GLC7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011059 VERSION NP_011059.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179023.3 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07793. On Jul 30, 2012 this sequence version replaced NP_011059.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..312 /product="type 1 serine/threonine-protein phosphatase catalytic subunit GLC7" /EC_number="3.1.3.16" /calculated_mol_wt="35776" Region 7..297 /region_name="MPP_PP1_PPKL" /note="PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain; cd07414" /db_xref="CDD:277359" Site order(63,65,91,95,123..124,128..129,133,172,194..196,205, 219..221,247,271..275) /site_type="active" /db_xref="CDD:277359" Site order(63,65,91,123,172,247) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277359" Site order(95,128..129,133,194..196,205,219..221,271..275) /site_type="other" /note="natural toxin binding site [chemical binding]" /db_xref="CDD:277359" Site order(178,180,197,202,215,224,232..233,235..237,239..241, 256,260,287..288,290,292,294) /site_type="other" /note="MYPT1 binding site [polypeptide binding]" /db_xref="CDD:277359" CDS 1..312 /gene="GLC7" /locus_tag="YER133W" /gene_synonym="CID1; DIS2" /coded_by="NM_001179023.3:1..939" /experiment="EXISTENCE:direct assay:GO:0000164 protein phosphatase type 1 complex [PMID:8289829]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:19948764]" /experiment="EXISTENCE:direct assay:GO:0001400 mating projection base [PMID:10747092]" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:1660885]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23418575]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11412094]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10747092]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11412094]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:26771880]" /experiment="EXISTENCE:genetic interaction:GO:0000076 DNA replication checkpoint signaling [PMID:19884341]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:29529242]" /experiment="EXISTENCE:genetic interaction:GO:0008360 regulation of cell shape [PMID:12477789]" /experiment="EXISTENCE:genetic interaction:GO:0031536 positive regulation of exit from mitosis [PMID:37690059]" /experiment="EXISTENCE:genetic interaction:GO:2000370 positive regulation of clathrin-dependent endocytosis [PMID:12356757]" /experiment="EXISTENCE:mutant phenotype:GO:0000076 DNA replication checkpoint signaling [PMID:19884341]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:19884341]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:11973298]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:25730376]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:10072383]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:10072380]" /experiment="EXISTENCE:mutant phenotype:GO:0007116 regulation of cell budding [PMID:10639337]" /experiment="EXISTENCE:mutant phenotype:GO:0007346 regulation of mitotic cell cycle [PMID:23418575]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10207049]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:9584086]" /experiment="EXISTENCE:mutant phenotype:GO:0031297 replication fork processing [PMID:19884341]" /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:19948764]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:8164671|PMID:7891699|PMID:10072380|PMID:9584086]" /experiment="EXISTENCE:mutant phenotype:GO:0070873 regulation of glycogen metabolic process [PMID:1660885]" /experiment="EXISTENCE:mutant phenotype:GO:1901901 regulation of protein localization to cell division site involved in cytokinesis [PMID:26771880]" /experiment="EXISTENCE:mutant phenotype:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:26771880]" /experiment="EXISTENCE:physical interaction:GO:0000164 protein phosphatase type 1 complex [PMID:19948764]" /experiment="EXISTENCE:physical interaction:GO:0051321 meiotic cell cycle [PMID:8754819]" /note="Type 1 S/T protein phosphatase (PP1) catalytic subunit; involved in glycogen metabolism, sporulation and mitotic progression; interacts with multiple regulatory subunits; regulates actomyosin ring formation; subunit of CPF; recruited to mating projections by Afr1p interaction; regulates nucleocytoplasmic shuttling of Hxk2p; import into the nucleus is inhibited during spindle assembly checkpoint arrest; involved in dephosphorylating Rps6a/b and Bnr1p" /db_xref="GeneID:856870" /db_xref="SGD:S000000935" ORIGIN 1 mdsqpvdvdn iidrllevrg skpgqqvdle eneirylcsk arsifikqpi lleleapiki 61 cgdihgqyyd llrlfeyggf ppesnylflg dyvdrgkqsl eticlllayk ikypenffil 121 rgnhecasin riygfydeck rryniklwkt ftdcfnclpi aaiidekifc mhgglspdln 181 smeqirrvmr ptdipdvgll cdllwsdpdk divgwsendr gvsftfgpdv vnrflqkqdm 241 elicrahqvv edgyeffskr qlvtlfsapn ycgefdnaga mmsvdesllc sfqilkpaqk 301 slprqaggrk kk // LOCUS NP_011060 178 aa linear PLN 30-JUN-2025 DEFINITION Mg-dependent acid phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011060 VERSION NP_011060.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179024.1 REFERENCE 1 (residues 1 to 178) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 178) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 178) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 178) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07794. Method: conceptual translation. FEATURES Location/Qualifiers source 1..178 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..178 /product="Mg-dependent acid phosphatase" /EC_number="3.1.3.48" /calculated_mol_wt="20310" Region 4..175 /region_name="MDP-1" /note="magnesium-dependent phosphatase-1; TIGR01685" /db_xref="CDD:273756" Site order(11..15,74..75,114,140..141,144..145) /site_type="active" /db_xref="CDD:319804" CDS 1..178 /locus_tag="YER134C" /coded_by="NM_001179024.1:1..537" /experiment="EXISTENCE:direct assay:GO:0003993 acid phosphatase activity [PMID:11601995]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030946 protein tyrosine phosphatase activity, metal-dependent [PMID:11601995]" /note="Magnesium-dependent acid phosphatase; member of the haloacid dehalogenase superfamily; non-essential gene" /db_xref="GeneID:856873" /db_xref="SGD:S000000936" ORIGIN 1 mtgypdvaaf dldytiwpcy cdthlhgpfk pvkssngevl tiicrdgyel tiykdipril 61 gdlkdngvkl mtasrtwape iaqeilkifk vkyagvvtpl anlfdefqwg erskighlrd 121 glkdlyntsd lkskkiclfd desrnkevek ygvkfvyvrd pengpswkly qdylsgkv // LOCUS NP_001335768 130 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER135C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335768 VERSION NP_001335768.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348826.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80288. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..130 /product="uncharacterized protein" /calculated_mol_wt="15290" CDS 1..130 /locus_tag="YER135C" /coded_by="NM_001348826.1:1..393" /note="hypothetical protein; conserved among S. cerevisiae strains; YER135C is not an essential gene" /db_xref="GeneID:856874" /db_xref="SGD:S000000937" ORIGIN 1 mtwtlrnlhn sqkkvlvdit iwlalspygd malftsfeni igeyyrysil plhqnlhkll 61 ftlfliclas wkegnrscry kwqkfvcnkl nspetnfvpi rtsvnknskm ivekqisihi 121 slkcivykey // LOCUS NP_011062 451 aa linear PLN 30-JUN-2025 DEFINITION Gdi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011062 VERSION NP_011062.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179026.1 REFERENCE 1 (residues 1 to 451) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 451) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 451) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 451) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07795. Method: conceptual translation. FEATURES Location/Qualifiers source 1..451 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..451 /product="Gdi1p" /calculated_mol_wt="51075" Region 1..447 /region_name="GDI" /note="GDP dissociation inhibitor; pfam00996" /db_xref="CDD:395792" CDS 1..451 /gene="GDI1" /locus_tag="YER136W" /gene_synonym="SEC19" /coded_by="NM_001179026.1:1..1356" /experiment="EXISTENCE:direct assay:GO:0005093 Rab GDP-dissociation inhibitor activity [PMID:8157010]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:8157010]" /note="GDP dissociation inhibitor; regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins" /db_xref="GeneID:856876" /db_xref="SGD:S000000938" ORIGIN 1 mdqetidtdy dvivlgtgit ecilsgllsv dgkkvlhidk qdhyggeaas vtlsqlyekf 61 kqnpiskeer eskfgkdrdw nvdlipkflm angeltnili htdvtryvdf kqvsgsyvfk 121 qgkiykvpan eieaissplm gifekrrmkk flewissyke ddlsthqgld ldkntmdevy 181 ykfglgnstk efighamalw tnddylqqpa rpsferilly cqsvarygks pylypmyglg 241 elpqgfarls aiyggtymld tpidevlykk dtgkfegvkt klgtfkaplv iadptyfpek 301 ckstgqrvir aicilnhpvp ntsnadslqi iipqsqlgrk sdiyvaivsd ahnvcskghy 361 laiistiiet dkphielepa fkllgpieek fmgiaelfep redgskdniy lsrsydassh 421 fesmtddvkd iyfrvtghpl vlkqrqeqek q // LOCUS NP_011063 148 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER137C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011063 VERSION NP_011063.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179027.3 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07796. On Jul 30, 2012 this sequence version replaced NP_011063.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..148 /product="uncharacterized protein" /calculated_mol_wt="16472" Region <127..142 /region_name="zf-C2H2_10" /note="C2H2 zinc-finger; pfam16588" /db_xref="CDD:374649" CDS 1..148 /locus_tag="YER137C" /coded_by="NM_001179027.3:1..447" /note="hypothetical protein" /db_xref="GeneID:856877" /db_xref="SGD:S000000939" ORIGIN 1 mcessnkten divrlsqamd vlakliiskq kdgsqlqvey ehklkelekf inlllglhes 61 tvgsmmntsv ldmvlrngie imekddqkya lipikakeea dkttstiqgv tskksskkkk 121 nkikcsfche aghtrahcga rltvipkk // LOCUS NP_011064 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011064 VERSION NP_011064.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179028.4 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07797. On Jul 30, 2012 this sequence version replaced NP_011064.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198432" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YER138C" /coded_by="join(NM_001179028.4:1..1302, NM_001179028.4:1304..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:856879" /db_xref="SGD:S000000940" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsd dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd eyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_058155 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058155 VERSION NP_058155.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184428.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07798. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..440 /product="gag protein" /calculated_mol_wt="48822" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YER137C-A" /coded_by="NM_001184428.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:856880" /db_xref="SGD:S000007402" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_011065 34 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER138W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011065 VERSION NP_011065.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184332.1 REFERENCE 1 (residues 1 to 34) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 34) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 34) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 34) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 34) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07799. Method: conceptual translation. FEATURES Location/Qualifiers source 1..34 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..34 /product="uncharacterized protein" /calculated_mol_wt="3823" CDS 1..34 /locus_tag="YER138W-A" /coded_by="NM_001184332.1:1..105" /note="hypothetical protein; YER138W-A has a paralog, YBL107W-A, that arose from a single-locus duplication" /db_xref="GeneID:856881" /db_xref="SGD:S000007239" ORIGIN 1 miiifielcr iadsllwipk ssrrtssist ylil // LOCUS NP_011066 226 aa linear PLN 30-JUN-2025 DEFINITION RNA polymerase II subunit B1 CTD phosphatase RTR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011066 VERSION NP_011066.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179029.3 REFERENCE 1 (residues 1 to 226) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 226) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 226) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07800. On Jul 30, 2012 this sequence version replaced NP_011066.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..226 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..226 /product="RNA polymerase II subunit B1 CTD phosphatase RTR1" /EC_number="3.1.3.16" /calculated_mol_wt="26109" Region 53..128 /region_name="RPAP2_Rtr1" /note="Rtr1/RPAP2 family; pfam04181" /db_xref="CDD:461212" CDS 1..226 /gene="RTR1" /locus_tag="YER139C" /coded_by="NM_001179029.3:1..681" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18408053]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:18408053]" /experiment="EXISTENCE:direct assay:GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity [PMID:19394294]" /experiment="EXISTENCE:genetic interaction:GO:0006366 transcription by RNA polymerase II [PMID:18408053]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:18408053]" /experiment="EXISTENCE:physical interaction:GO:0006366 transcription by RNA polymerase II [PMID:18408053]" /note="Dual specificity protein phosphatase; dephosphorylates T1 and S5 in C-terminal domain (CTD) of RNA polymerase II largest subunit, Rpo21p; autoregulates turnover of its mRNA; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm; RTR1 has a paralog, RTR2, that arose from the whole genome duplication" /db_xref="GeneID:856882" /db_xref="SGD:S000000941" ORIGIN 1 matiediket alipfqkhrq lsmheaevit leiigllcds eckdektlky lgrfltpdmy 61 qdlvdernln krcgyplcgk sperirdpfs mndttkkfll ennpyaylsh ycskfhfrcs 121 qfyqvqlsde alfartgvhl fedpeqdkhd idfkvtlfee llrekaseed ikslisglkk 181 lglnpdsgtt ekddteledd lskwlaqiki vendnpsilg dftred // LOCUS NP_011067 556 aa linear PLN 30-JUN-2025 DEFINITION Emp65p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011067 VERSION NP_011067.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179030.3 REFERENCE 1 (residues 1 to 556) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 556) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 556) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 556) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07801. On Jul 30, 2012 this sequence version replaced NP_011067.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..556 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..556 /product="Emp65p" /calculated_mol_wt="64663" Region 143..455 /region_name="DUF747" /note="Eukaryotic membrane protein family; pfam05346" /db_xref="CDD:398815" CDS 1..556 /gene="EMP65" /locus_tag="YER140W" /coded_by="NM_001179030.3:1..1671" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:23275891]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]" /note="Integral membrane protein of the ER; forms an ER-membrane associated protein complex with Slp1p; identified along with SLP1 in a screen for mutants defective in the unfolded protein response (UPR); proposed to function in the folding of integral membrane proteins; interacts genetically with MPS3; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:856883" /db_xref="SGD:S000000942" ORIGIN 1 mqhkdtavak dtakkrllrr nsapsaihii srldkkwsfl wntidrhniv eeqdessaak 61 seeeheddye leqllnmiri pmflekfmlf alltsldcfl yyftvlpirl ikgyvkqfks 121 yrqhyrlqqr sghknkipfr yritsreyke rcmifiivis sillskldts klyhrikrqs 181 tmklymlfsv lemadkmlas lgqslltvml srknserill hkcllvsmsl tyvtihgyvl 241 vyqaislnia vnsysnallt lllsmqfaei kssvlkkfdk egffqitiad vverfkltll 301 lsitglrnlq swssslsnts infwsprstl sivinilcgp mvsvvgsevl vdwakhayit 361 kfnrirpqiy dkfyyiiykd ystrthkled rlglplpafv vlfivmvrpt lfkssepsyl 421 pslfrilfmg asvfllalla kftldlilik wskrieqrfr dqafntvvte eeyvpgllsg 481 gmgkvdvstr ialhsdynke nrietesvsp mrkrkttlta ectppslndi rrqkdsknpr 541 slenvarykm vskriw // LOCUS NP_011068 486 aa linear PLN 30-JUN-2025 DEFINITION Cox15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011068 VERSION NP_011068.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179031.1 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07802. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..486 /product="Cox15p" /EC_number="1.17.99.9" /calculated_mol_wt="54527" Region 15..451 /region_name="COX15-CtaA" /note="Cytochrome oxidase assembly protein; cl19388" /db_xref="CDD:473166" CDS 1..486 /gene="COX15" /locus_tag="YER141W" /coded_by="NM_001179031.1:1..1461" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9228094]" /experiment="EXISTENCE:genetic interaction:GO:0006784 heme A biosynthetic process [PMID:11788607]" /experiment="EXISTENCE:genetic interaction:GO:0120547 heme A synthase activity [PMID:11788607]" /experiment="EXISTENCE:mutant phenotype:GO:0006784 heme A biosynthetic process [PMID:11788607]" /experiment="EXISTENCE:mutant phenotype:GO:0120547 heme A synthase activity [PMID:26940873|PMID:11248251]" /note="Heme a synthase; required for the hydroxylation of heme O to form heme A, an essential prosthetic group for cytochrome c oxidase; oligomerization is required for function" /db_xref="GeneID:856884" /db_xref="SGD:S000000943" ORIGIN 1 mlfrnievgr qaaklltrts srlawqsiga srnistirqq irktqlynfk ktvsirpfsl 61 sspvfkphva sesnpiesrl ktsknvaywl igtsglvfgi vvlggltrlt esglsitewk 121 pvtgtlppmn qkeweeefik ykespefkll nshidldefk fiffmewihr lwgraigavf 181 ilpavyfavs kktsghvnkr lfglagllgl qgfvgwwmvk sgldqeqlda rkskptvsqy 241 rltthlgtaf flymgmlwtg leilreckwi knpvqaislf kkldnpaigp mrkislalla 301 vsfltamsgg mvagldagwv yntwpkmger wfpssrelmd enfcrredkk dlwwrnllen 361 pvtvqlvhrt cayvaftsvl aahmyaikkk aviprnamts lhvmmgvvtl qatlgiltil 421 ylvpislasi hqagalallt sslvfasqlr kprapmrnvi itlphsskvt sgkilseask 481 laskpl // LOCUS NP_011069 296 aa linear PLN 30-JUN-2025 DEFINITION DNA-3-methyladenine glycosylase II [Saccharomyces cerevisiae S288C]. ACCESSION NP_011069 VERSION NP_011069.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179032.1 REFERENCE 1 (residues 1 to 296) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 296) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 296) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 296) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07803. Method: conceptual translation. FEATURES Location/Qualifiers source 1..296 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..296 /product="DNA-3-methyladenine glycosylase II" /EC_number="3.2.2.21" /calculated_mol_wt="34202" Region <47..277 /region_name="AlkA" /note="3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair]; COG0122" /db_xref="CDD:439892" CDS 1..296 /gene="MAG1" /locus_tag="YER142C" /gene_synonym="MMS5" /coded_by="NM_001179032.1:1..891" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:2265619]" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:18472311]" /experiment="EXISTENCE:direct assay:GO:0003905 alkylbase DNA N-glycosylase activity [PMID:2682633|PMID:2265619]" /experiment="EXISTENCE:direct assay:GO:0008725 DNA-3-methyladenine glycosylase activity [PMID:18472311]" /experiment="EXISTENCE:genetic interaction:GO:0006285 base-excision repair, AP site formation [PMID:18043759]" /experiment="EXISTENCE:mutant phenotype:GO:0006285 base-excision repair, AP site formation [PMID:18043759]" /experiment="EXISTENCE:mutant phenotype:GO:0006307 DNA alkylation repair [PMID:2265620]" /note="3-methyl-adenine DNA glycosylase; initiates base excision repair (BER) by removing damaged bases to create abasic sites that are subsequently repaired; expansion of BER repair removes alkylated bases resulting from alkylating agent-induced DNA damage, compensating for the lack of DNA repair by oxidative dealkylation; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856885" /db_xref="SGD:S000000944" ORIGIN 1 mklkreydel ikadavkeia kelgsrplev alpekyiarh eekfnmaceh ilekdpslfp 61 ilknneftly lketqvpntl edyfirlast ilsqqisgqa aesikarvvs lyggafpdyk 121 ilfedfkdpa kcaeiakcgl skrkmiyles lavyftekyk dieklfgqkd ndeevieslv 181 tnvkgigpws akmflisglk rmdvfapedl giargfskyl sdkpelekel mrerkvvkks 241 kikhkkynwk iydddimekc setfspyrsv fmfilwrlas tntdammkae enfvks // LOCUS NP_011070 428 aa linear PLN 30-JUN-2025 DEFINITION Ddi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011070 VERSION NP_011070.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179033.3 REFERENCE 1 (residues 1 to 428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 428) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07804. On Jul 30, 2012 this sequence version replaced NP_011070.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..428 /product="Ddi1p" /calculated_mol_wt="47223" Region 1..74 /region_name="Ubl_Ddi1_like" /note="ubiquitin-like (Ubl) domain found in the eukaryotic Ddi1 family; cd01796" /db_xref="CDD:340494" Region 188..310 /region_name="RP_DDI" /note="retropepsin-like domain of DNA damage inducible protein; cd05479" /db_xref="CDD:133146" Site 220..222 /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:133146" Site 220 /site_type="active" /note="Catalytic residue [active]" /db_xref="CDD:133146" Region <324..>427 /region_name="rad23" /note="UV excision repair protein Rad23; TIGR00601" /db_xref="CDD:273167" Region 392..427 /region_name="UBA_scDdi1_like" /note="UBA domain found in Saccharomyces cerevisiae DNA-damage response protein Ddi1 and similar proteins; cd14309" /db_xref="CDD:270494" CDS 1..428 /gene="DDI1" /locus_tag="YER143W" /gene_synonym="VSM1" /coded_by="NM_001179033.3:1..1287" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:10330187]" /experiment="EXISTENCE:direct assay:GO:0004190 aspartic-type endopeptidase activity [PMID:32193351]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10330187]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:15964793]" /experiment="EXISTENCE:direct assay:GO:0031593 polyubiquitin modification-dependent protein binding [PMID:32193351]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:11323716]" /experiment="EXISTENCE:direct assay:GO:1904855 proteasome regulatory particle binding [PMID:15964793]" /experiment="EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:29444958]" /experiment="EXISTENCE:mutant phenotype:GO:0004190 aspartic-type endopeptidase activity [PMID:32193351]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:12051757]" /experiment="EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:21094643]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:10330187]" /experiment="EXISTENCE:mutant phenotype:GO:0031593 polyubiquitin modification-dependent protein binding [PMID:32193351]" /experiment="EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:29444958]" /experiment="EXISTENCE:mutant phenotype:GO:0045740 positive regulation of DNA replication [PMID:31276951]" /note="Aspartic-type endopeptidase; involved in the cleavage of long-chain polyubiquitinated substrates; role in proteasome-independent, ubiquitin (Ub)-dependent proteolysis and DNA-protein crosslink repair; Ub-shuttle receptor for HO and Ufo1p; DNA damage-inducible v-SNARE binding protein and negative regulator of constitutive exocytosis; possible role in the S-phase checkpoint; UBL-UBA family member containing Ub-like (UBL), helical, Ub-associated (UBA) and retroviral-like proteinase (RVP) domains" /db_xref="GeneID:856886" /db_xref="SGD:S000000945" ORIGIN 1 mdltisnelt geiygpievs edmaltdlia llqadcgfdk tkhdlyynmd ildsnrtqsl 61 kelglktddl llirgkisns iqtdaatlsd eafieqfrqe llnnqmlrsq lilqipglnd 121 lvndpllfre rlgplilqrr yggyntamnp fgipqdeytr lmanpddpdn kkriaelldq 181 qaideqlrna ieytpemftq vpmlyiniei nnypvkafvd tgaqttimst rlakktglsr 241 midkrfigea rgvgtgkiig rihqaqvkie tqyipcsftv ldtdidvlig ldmlkrhlac 301 vdlkenvlri aevetsflse aeipksfqeg lpaptsvtts sdkpltptkt sstlppqpga 361 vpalaprtgm gptptgrsta gattatgrtf peqtikqlmd lgfprdavvk alkqtngnae 421 faasllfq // LOCUS NP_011071 805 aa linear PLN 30-JUN-2025 DEFINITION putative ubiquitin-specific protease UBP5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011071 VERSION NP_011071.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179034.3 REFERENCE 1 (residues 1 to 805) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 805) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 805) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 805) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07805. On Jul 30, 2012 this sequence version replaced NP_011071.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..805 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..805 /product="putative ubiquitin-specific protease UBP5" /EC_number="3.4.19.12" /calculated_mol_wt="92130" Region 159..280 /region_name="RHOD" /note="Rhodanese Homology Domain; smart00450" /db_xref="CDD:197731" Region 446..801 /region_name="UCH" /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443" /db_xref="CDD:425685" Site order(450,455,761,779) /site_type="active" /db_xref="CDD:239139" CDS 1..805 /gene="UBP5" /locus_tag="YER144C" /coded_by="NM_001179034.3:1..2418" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:17145966]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17145966]" /note="Putative ubiquitin-specific protease; concentrates at the bud neck; UBP5 has a paralog, DOA4, that arose from the whole genome duplication" /db_xref="GeneID:856887" /db_xref="SGD:S000000946" ORIGIN 1 mgseqalsev vesakerfgr lrhlvqkfld dddvpqeclp llqecaeiws syvdacqdit 61 mqapkedanr lskgflrlne taflyymivy tlledtlprl kefssnkdqn vrnlygeriq 121 llhndpnier irnvienypk fiqlqtiepg klssmlhfhg dalllidvrp rsefvrahik 181 ckniicidpa sfkdsftdqq iesvslitsp hsditffsnr dkfkfiilyt dtqlhnnfqq 241 rqtrilakil sqnsvikpls gtkilileng fsnwvklgga yqssvsetah ltsssstpaf 301 gspqvptglf nqkslspnkd ksmpmvsmnt qpllttvqrp qlplyysdlp iipqpspnrn 361 sptvqkfsph ppttlsklnt pstiqnkant verispdira aqahaylppa snvfspripp 421 lpqqnlsssr qtilnnsqvl dldlivglen ignccymnci lqclvgthdl vrmfldntyl 481 nfinfdssrg skgllaknfa ilvnnmhrhg aftppnvrti pvqtiqfkki cghinpmysd 541 smqqdcqefc qflldglhed lnqngskkhl kqlsdeeerm rekmsirkas alewerfllt 601 dfsaiidlfq gqyasrlqcq vcehtsttyq tfsvlsvpvp rvktcnildc freftkcerl 661 gvdeqwscpk clkkqpstkq lkitrlpkkl iinlkrfdnq mnknnvfvqy pysldltpyw 721 ardfnheaiv nediptrgqv ppfryrlygv achsgslygg hytsyvykgp kkgwyffdds 781 lyrpitfste fitpsayvlf yerif // LOCUS NP_011072 404 aa linear PLN 30-JUN-2025 DEFINITION high-affinity iron permease FTR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011072 VERSION NP_011072.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179035.1 REFERENCE 1 (residues 1 to 404) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 404) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 404) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 404) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07806. Method: conceptual translation. FEATURES Location/Qualifiers source 1..404 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..404 /product="high-affinity iron permease FTR1" /calculated_mol_wt="45591" Region 16..320 /region_name="FTR1" /note="Iron permease FTR1 family; pfam03239" /db_xref="CDD:251822" CDS 1..404 /gene="FTR1" /locus_tag="YER145C" /coded_by="NM_001179035.1:1..1215" /experiment="EXISTENCE:direct assay:GO:0005381 iron ion transmembrane transporter activity [PMID:8599111|PMID:16700543]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16700543|PMID:10748025]" /experiment="EXISTENCE:direct assay:GO:0033573 high-affinity iron permease complex [PMID:16522632]" /experiment="EXISTENCE:genetic interaction:GO:0034755 iron ion transmembrane transport [PMID:8599111]" /experiment="EXISTENCE:genetic interaction:GO:1901684 arsenate ion transmembrane transport [PMID:23295455]" /experiment="EXISTENCE:mutant phenotype:GO:0034755 iron ion transmembrane transport [PMID:8599111|PMID:16700543]" /note="High affinity iron permease; involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856888" /db_xref="SGD:S000000947" ORIGIN 1 mpnkvfnvav ffvvfrecle avivisvlls flkqaigehd ralyrklriq vwvgvllgfi 61 iclaigagfi gayyslqkdi fgsaedlweg ifcmiatimi smmgipmlrm nkmqskwrvk 121 iarslveiph rkrdyfkigf lsrryamfll pfitvlregl eavvfvagag ittqgshasa 181 yplpvvvgli cgglvgylly ygasksslqi flilstsily lisaglfsrg awyfenyrfn 241 lasggdaseg gdgngsynir kavyhvnccn peldngwdif nallgwqntg ylssmlcyni 301 ywlvliivls lmifeerrgh lpftknlqlk hlnpgywikn kkkqelteeq krqlfakmen 361 infnedgein vqenyelpeq ttshsssqnv atdkevlhvk adsl // LOCUS NP_001335769 145 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER145C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335769 VERSION NP_001335769.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348827.1 REFERENCE 1 (residues 1 to 145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 145) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80289. Method: conceptual translation. FEATURES Location/Qualifiers source 1..145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..145 /product="uncharacterized protein" /calculated_mol_wt="15887" CDS 1..145 /locus_tag="YER145C-A" /coded_by="NM_001348827.1:1..438" /note="hypothetical protein; conserved among S. cerevisiae strains; overlaps verified ORF LSM5/YER146W" /db_xref="GeneID:31009439" /db_xref="SGD:S000028758" ORIGIN 1 maillplksi lpwccitfsf llsssgsish stasssitlt ksskptnvps nsrfdcstin 61 tfwlivlsmt skgkisgrli lrasvyacec tciryaccet iypprkpfsl slyffyfnkk 121 asilfcypda ktkpehpgnk ragsg // LOCUS NP_011073 93 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding protein LSM5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011073 VERSION NP_011073.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179036.1 REFERENCE 1 (residues 1 to 93) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 93) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 93) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 93) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07807. Method: conceptual translation. FEATURES Location/Qualifiers source 1..93 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..93 /product="RNA-binding protein LSM5" /calculated_mol_wt="10292" Region 6..85 /region_name="LSm5" /note="Like-Sm protein 5; cd01732" /db_xref="CDD:212479" Site order(12,15..16,21,23..25,28,30,35..38,41..42,44,70..82) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:212479" Site order(20..26,28..40,42..46) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212479" Site order(38,40,74) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:212479" Site 70..81 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212479" CDS 1..93 /gene="LSM5" /locus_tag="YER146W" /coded_by="NM_001179036.1:1..282" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:15075370|PMID:10369684]" /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:11720284|PMID:10369684]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15075370]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970]" /experiment="EXISTENCE:physical interaction:GO:0005732 sno(s)RNA-containing ribonucleoprotein complex [PMID:15075370]" /note="Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA" /db_xref="GeneID:856889" /db_xref="SGD:S000000948" ORIGIN 1 mslpeilple vidktinqkv livlqsnref egtlvgfddf vnviledave wlidpedesr 61 nekvmqhhgr mllsgnniai lvpggkktpt eal // LOCUS NP_011074 624 aa linear PLN 30-JUN-2025 DEFINITION cohesin-loading factor complex subunit SCC4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011074 VERSION NP_011074.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179037.3 REFERENCE 1 (residues 1 to 624) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 624) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 624) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 624) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07808. On Jul 30, 2012 this sequence version replaced NP_011074.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..624 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..624 /product="cohesin-loading factor complex subunit SCC4" /calculated_mol_wt="72010" Region 13..610 /region_name="Cohesin_load" /note="Cohesin loading factor; pfam10345" /db_xref="CDD:463053" CDS 1..624 /gene="SCC4" /locus_tag="YER147C" /coded_by="NM_001179037.3:1..1875" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10882066]" /experiment="EXISTENCE:direct assay:GO:0043515 kinetochore binding [PMID:28938124]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:15610742]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:10882066]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:18708580]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:18708580]" /experiment="EXISTENCE:mutant phenotype:GO:0071169 establishment of protein localization to chromatin [PMID:10882066]" /experiment="EXISTENCE:physical interaction:GO:0032116 SMC loading complex [PMID:10882066]" /note="Subunit of cohesin loading factor (Scc2p-Scc4p); complex is required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX" /db_xref="GeneID:856890" /db_xref="SGD:S000000949" ORIGIN 1 menlgdklsi sqvyhlaqey rdhaysiank igseeglkqy yglmnmsiqm fqllktkctl 61 svledskvtf emvelliqet ynfdlaelyi sslkerlqth qsdtdlveei mrceflllhd 121 lplmrdskfh ykialrncne lvqymvnlqd elyqnwasvf qyvgvmlcik lkqhrrvkts 181 fhgllsqcre ksqwkwflnl cyvnyllner fpipedalqe lrstelhtvg pelyawklal 241 emviqlckdg nitdhlnefk nffdtnkqsl vtnegkgcvi kimprialkv elpmifhyke 301 lknillllqs vsyivncyde kgnfsrkflp kvysttqkli kniaaggvsm neldsriqty 361 ksilefcefy kvweqtllkg avvttespkl gpspgyvrll qamkvqfegg gaveeytrla 421 qsggtssevk misllncytv qaarvsrcsg dkqgelveqc nkvwlqvekl lqetdlqfnp 481 iwectvtilw lfshfepfsw nplpcsdkqr aeyvsklref yssnkfvage avadnrfklk 541 kalllqilvn ylggrmlehd lgeiyaisak cfdmcrqqgg mrkvqyvigi whlmnctvam 601 rgkdvaltna klealvkqit svkq // LOCUS NP_011075 240 aa linear PLN 30-JUN-2025 DEFINITION TATA-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011075 VERSION NP_011075.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179038.3 REFERENCE 1 (residues 1 to 240) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 240) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 240) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 240) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07809. On Jul 30, 2012 this sequence version replaced NP_011075.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..240 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..240 /product="TATA-binding protein" /calculated_mol_wt="26872" Region 64..239 /region_name="PLN00062" /note="TATA-box-binding protein; Provisional" /db_xref="CDD:177693" CDS 1..240 /gene="SPT15" /locus_tag="YER148W" /gene_synonym="BTF1; TBP1" /coded_by="NM_001179038.3:1..723" /experiment="EXISTENCE:direct assay:GO:0000126 transcription factor TFIIIB complex [PMID:1423590|PMID:1458536]" /experiment="EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:2677740]" /experiment="EXISTENCE:direct assay:GO:0001016 RNA polymerase III transcription regulatory region sequence-specific DNA binding [PMID:8662956]" /experiment="EXISTENCE:direct assay:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:8895657]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:19098311]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9818719]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:1736286]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]" /experiment="EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:1480467]" /experiment="EXISTENCE:mutant phenotype:GO:0001188 RNA polymerase I preinitiation complex assembly [PMID:8895657]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:1586947]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]" /experiment="EXISTENCE:physical interaction:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:8895657]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]" /note="TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP" /db_xref="GeneID:856891" /db_xref="SGD:S000000950" ORIGIN 1 madeerlkef keankivfdp ntrqvwenqn rdgtkpattf qseedikraa pesekdtsat 61 sgivptlqni vatvtlgcrl dlktvalhar naeynpkrfa avimrirepk ttalifasgk 121 mvvtgaksed dsklasrkya riiqkigfaa kftdfkiqni vgscdvkfpi rleglafshg 181 tfssyepelf pgliyrmvkp kivllifvsg kivltgakqr eeiyqafeai ypvlsefrkm // LOCUS NP_011076 420 aa linear PLN 30-JUN-2025 DEFINITION Pea2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011076 VERSION NP_011076.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179039.1 REFERENCE 1 (residues 1 to 420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 420) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07810. Method: conceptual translation. FEATURES Location/Qualifiers source 1..420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..420 /product="Pea2p" /calculated_mol_wt="48034" Region 228..>317 /region_name="EnvC" /note="Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]; COG4942" /db_xref="CDD:443969" CDS 1..420 /gene="PEA2" /locus_tag="YER149C" /gene_synonym="DFG9; PPF2" /coded_by="NM_001179039.1:1..1263" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:8909546]" /experiment="EXISTENCE:direct assay:GO:0000133 polarisome [PMID:9632790]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:8909546]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:8909546]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:8909546]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:33656555]" /experiment="EXISTENCE:direct assay:GO:0031489 myosin V binding [PMID:33656555]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807|PMID:8909546]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:8013906|PMID:8909546]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:8909546]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:8013906|PMID:8909546|PMID:33656555]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:15645503]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:10085294|PMID:11740491|PMID:8909546]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:17237521|PMID:19633059]" /experiment="EXISTENCE:mutant phenotype:GO:0071468 cellular response to acidic pH [PMID:19633059]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:17237521]" /note="Coiled-coil 12S polarisome subunit; required for polarity establishment, apical bud growth, shmoo formation, filamentous differentiation; involved in Bni1p localization at sites of polarized growth, controlling polarized assembly of actin cables; role in apical growth affects diploid-specific bipolar bud site selection; retains Slt2p at bud tip to regulate ER inheritance; role in Ca2+ influx, cell fusion; S288C allele encoding Leu409 rather than Met linked with non-invasion" /db_xref="GeneID:856892" /db_xref="SGD:S000000951" ORIGIN 1 mhkfdlelsr ranpllfsae ryeeyplkyd elkqyllsqn pshphhnsrp ytsidyfdyl 61 lyrskndese idldkklvse falyyvqkeh lnsddlnptl nellklqpks adwyemmlri 121 lesinttgid qltkennnsf pnskrarsst nmggtdkfnk gayhtdkadd dkneilqelt 181 sflmsnsiqk gidikpipld dpvkflkngi nsildtcvsl ekntssppis pnaaaiqeed 241 sskkleelet afsdlqlahn fltkqfendr aeyvqdiekl trtnrelqdk llnnhsnlsk 301 tekklheleq enkelekann klnssrhnfg msspasspvt wdpsspssvg sptsgsgsrs 361 lsimtsefkk vltstqrkye kelsderehr fklerelall knaeantsla lnrddppdml // LOCUS NP_011077 148 aa linear PLN 30-JUN-2025 DEFINITION Spi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011077 VERSION NP_011077.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179040.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07811. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..148 /product="Spi1p" /calculated_mol_wt="14865" CDS 1..148 /gene="SPI1" /locus_tag="YER150W" /coded_by="NM_001179040.1:1..447" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9613572]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0010447 response to acidic pH [PMID:16980434]" /note="GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; SPI1 has a paralog, SED1, that arose from the whole genome duplication" /db_xref="GeneID:856893" /db_xref="SGD:S000000952" ORIGIN 1 mlsnakllls lamastalgl vsnssssviv vpssdatiag ndtatpapep ssaapifyns 61 tatatqyevv sefttycpep ttfvtngatf tvtapttlti tncpctiekp tsetsvssth 121 dvetnsnaan araipgalgl agavmmll // LOCUS NP_011078 912 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding ubiquitin-specific protease UBP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011078 VERSION NP_011078.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179041.3 REFERENCE 1 (residues 1 to 912) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 912) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 912) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 912) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 912) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 912) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 912) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 912) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 912) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07812. On Jul 30, 2012 this sequence version replaced NP_011078.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..912 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..912 /product="mRNA-binding ubiquitin-specific protease UBP3" /EC_number="3.4.19.12" /calculated_mol_wt="101786" Region 460..908 /region_name="UCH" /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443" /db_xref="CDD:425685" CDS 1..912 /gene="UBP3" /locus_tag="YER151C" /gene_synonym="BLM3" /coded_by="NM_001179041.3:1..2739" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640|PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:1429680]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:18498751]" /experiment="EXISTENCE:genetic interaction:GO:0045053 protein retention in Golgi apparatus [PMID:32673164]" /experiment="EXISTENCE:mutant phenotype:GO:0004843 cysteine-type deubiquitinase activity [PMID:23476013]" /experiment="EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:23476013|PMID:23645675|PMID:18498751]" /experiment="EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:18391941]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:32673164]" /experiment="EXISTENCE:mutant phenotype:GO:0047484 regulation of response to osmotic stress [PMID:21743437]" /experiment="EXISTENCE:mutant phenotype:GO:0060628 regulation of ER to Golgi vesicle-mediated transport [PMID:12778054]" /experiment="EXISTENCE:physical interaction:GO:0047484 regulation of response to osmotic stress [PMID:21743437]" /experiment="EXISTENCE:physical interaction:GO:1990861 Ubp3-Bre5 deubiquitination complex [PMID:12778054]" /note="Ubiquitin-specific protease that cleaves Ub-protein fusions; interacts with cofactor Bre5p to regulate transport between ER and Golgi, deubiquitinating COPII and COPI proteins, Sec23p and Sec27p; mediates steady-state retention of Golgi membrane proteins with Bre5p; phosphorylation (S695) by Hog1p regulates transcriptional activation by osmostress; inhibits Ras/PKA signaling through Ira2p; inhibits silencing; role in ribophagy; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856895" /db_xref="SGD:S000000953" ORIGIN 1 mnmqdankee sysmypktss pppptptnmq ipiyqaplqm ygytqapyly ptqipaysfn 61 mvnqnqpiyh qsgsphhlpp qnninggstt nnnninkkkw hsngitnnng ssgnqganss 121 gsgmsynksh tyhhnysnnh ipmmaspnsg snagmkkqtn ssngngssat spsyssynss 181 sqydlykfdv tklknlkens snliqlplfi ntteaefaaa svqryelnmk alnlnsesle 241 nssvekssah hhtkshsipk hneevkteth geeedahdkk phaskdahel kkktevkked 301 akqdrnekvi qepqatvlpv vdkkepeesv eentsktssp spsppaaksw saiasdaiks 361 rqasnktvsg smvtktpisg ttagvsstnm aaatigksss pllskqpqkk dkkyvppstk 421 gieplgsial rmcfdpdfis yvlrnkdven kipvhsiipr giinranicf mssvlqvlly 481 ckpfidvinv lstrntnsrv gtssckllda cltmykqfdk etyekkflen addaekttes 541 dakkssksks fqhcatadav kpdefyktls tipkfkdlqw ghqedaeefl thlldqlhee 601 lisaidgltd neiqnmlqsi ndeqlkvffi rnlsrygkae fiknasprlk eliekygvin 661 ddsteengwh evsgsskrgk ktktaakrtv eivpspiskl fggqfrsvld ipnnkesqsi 721 tldpfqtiql disdagvndl etafkkfsey ellpfksssg ndveakkqtf idklpqvlli 781 qfkrfsfinn vnkdnamtny nayngrieki rkkikyghel iipeesmssi tlknntsgid 841 drrykltgvi yhhgvssdgg hytadvyhse hnkwyriddv niteledddv lkggeeasds 901 rtayilmyqk rn // LOCUS NP_011079 443 aa linear PLN 30-JUN-2025 DEFINITION 2-aminoadipate transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011079 VERSION NP_011079.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179042.3 REFERENCE 1 (residues 1 to 443) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 443) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 443) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 443) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07813. On Jul 30, 2012 this sequence version replaced NP_011079.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..443 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..443 /product="2-aminoadipate transaminase" /calculated_mol_wt="49359" Region <6..436 /region_name="ARO8" /note="DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; COG1167" /db_xref="CDD:440781" CDS 1..443 /locus_tag="YER152C" /coded_by="NM_001179042.3:1..1332" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0047536 2-aminoadipate transaminase activity [PMID:19342587]" /note="Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene" /db_xref="GeneID:856896" /db_xref="SGD:S000000954" ORIGIN 1 mkykeinffk ghpssrllpr eaviqataai lgpetreydn dpynrhplty gsdegalwvr 61 eqictflndq lfkfengars rtradylnln sgasygmlni llqttlphng ytrqafiitp 121 tyflinncft dagfkgkmta ineqghdsid feslisaleq heaepqphst temiqgpklt 181 kkvyryvmyc iptfanpsgn tysletrrrl idiarkydml iitddvydil dyttpsdelp 241 spplrmvhid rstapsgeds fgntvsnatf skliapglrf gyhesinanl arqlskggan 301 vsggtpsqln smivgemlrs gaaqrciahl rsvyseratv ltsalkkymp lgteimplkg 361 gyftwitlpp aynameisti lakkfnvila dgsnfevigd eknwgqscfr lsisflevdd 421 idrgielfga vckshaitnn itm // LOCUS NP_011080 254 aa linear PLN 30-JUN-2025 DEFINITION Pet122p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011080 VERSION NP_011080.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179043.1 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07814. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..254 /product="Pet122p" /calculated_mol_wt="29024" Region 6..248 /region_name="PET122" /note="pfam05476" /db_xref="CDD:368460" CDS 1..254 /gene="PET122" /locus_tag="YER153C" /coded_by="NM_001179043.1:1..765" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12529447|PMID:8389363]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:2833749]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:2833749]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:2833749]" /note="Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane" /db_xref="GeneID:856897" /db_xref="SGD:S000000955" ORIGIN 1 mltitkrlvt tdvrsrills slngkmsdal allrqqqqts vdvellhtml araaalahad 61 tiaymwyqhv mprrlpvegr llcemagval yqdrlflpaq flqhyqamnr drrtspedel 121 ieyelrrikv eafargtmhs talrekwkvf lqemdtlpgq pplrlrdfpq mtkamgialm 181 qqdeqaaala lfgrqplvik newslpllla gvlwhvpgpa qarrvlaefr qsyrglplld 241 aelvikrrgf eint // LOCUS NP_011081 402 aa linear PLN 30-JUN-2025 DEFINITION membrane insertase OXA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011081 VERSION NP_011081.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179044.1 REFERENCE 1 (residues 1 to 402) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 402) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 402) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 402) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07815. Method: conceptual translation. FEATURES Location/Qualifiers source 1..402 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..402 /product="membrane insertase OXA1" /calculated_mol_wt="44685" Region 125..319 /region_name="5TM_Oxa1-like" /note="Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; cd20069" /db_xref="CDD:410993" CDS 1..402 /gene="OXA1" /locus_tag="YER154W" /coded_by="NM_001179044.1:1..1209" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0030061 mitochondrial crista [PMID:22513091]" /experiment="EXISTENCE:direct assay:GO:0097002 mitochondrial inner boundary membrane [PMID:22513091]" /experiment="EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:14657018]" /experiment="EXISTENCE:mutant phenotype:GO:0032977 membrane insertase activity [PMID:9285818|PMID:9428747]" /experiment="EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:17452441|PMID:9428747|PMID:9482871|PMID:9285818]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:17344477]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:22846909]" /note="Mitochondrial inner membrane insertase; mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane; also has a role in insertion of carrier proteins into the inner membrane; acts as a voltage-gated ion channel, activated by substrate peptides; interacts with mitochondrial ribosomes; conserved from bacteria to animals" /db_xref="GeneID:856898" /db_xref="SGD:S000000956" ORIGIN 1 mfkltsrlvt srfaassrla tartivlprp hpswisfqak rfnstgpnan dvseiqtqlp 61 sideltssap slsastsdli anttqtvgel sshigylnsi glaqtwywps diiqhvleav 121 hvysglpwwg tiaattilir clmfplyvks sdtvarnshi kpeldalnnk lmsttdlqqg 181 qlvamqrkkl lsshgiknrw laapmlqipi algffnalrh manypvdgfa nqgvawftdl 241 tqadpylglq vitaavfisf trlggetgaq qfsspmkrlf tilpiisipa tmnlssavvl 301 yfafngafsv lqtmilrnkw vrsklkitev akprtpiaga sptenmgifq slkhniqkar 361 dqaerrqlmq dnekklqesf kekrqnskik ivhksnfinn kk // LOCUS NP_011082 2167 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein BEM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011082 VERSION NP_011082.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179045.3 REFERENCE 1 (residues 1 to 2167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2167) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 2167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 2167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 2167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07816. On Jul 30, 2012 this sequence version replaced NP_011082.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..2167 /product="GTPase-activating protein BEM2" /calculated_mol_wt="245300" Region 592..860 /region_name="RasGEF" /note="Guanine nucleotide exchange factor for Ras-like small GTPases; smart00147" /db_xref="CDD:214539" Site order(621..623,637..638,640..642,644..645,648..649,652,692, 695..696,698..700,702..705,707..708,728,731,736..738,741, 763..765,768..770,772..774,776..779,800,804,847,850..851) /site_type="other" /note="Ras interaction site [polypeptide binding]" /db_xref="CDD:238087" Region 1120..1291 /region_name="REM" /note="Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately...; cl02520" /db_xref="CDD:470601" Region <1877..1948 /region_name="PH" /note="PH domain; pfam00169" /db_xref="CDD:459697" Region 1981..2134 /region_name="RhoGAP" /note="RhoGAP domain; pfam00620" /db_xref="CDD:459875" CDS 1..2167 /gene="BEM2" /locus_tag="YER155C" /gene_synonym="IPL2; SUP9; TSL1" /coded_by="NM_001179045.3:1..6504" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:12145202|PMID:7962098]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:17914457]" /experiment="EXISTENCE:genetic interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:17914457]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:12145202]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:7579704]" /experiment="EXISTENCE:mutant phenotype:GO:0035024 negative regulation of Rho protein signal transduction [PMID:17914457]" /experiment="EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:12145202]" /note="Rho GTPase activating protein (RhoGAP); contains RhoGAP activity specific for both Rho1p and Cdc42p, and potentially Rho4p; acts with the RhoGAP Bem3p to negatively regulate Cdc42p-dependent signal transduction; involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence and for the morphogenesis checkpoint in response to actin depolymerization; localizes to sites of polarized growth and the plasma membrane" /db_xref="GeneID:856899" /db_xref="SGD:S000000957" ORIGIN 1 mkgllwsknr ksstasasss ststshkttt astassssps sssqtirnst sgaspymhsh 61 hhhgqghshh rgednnrdkr kssvfppskq ytstsssqvn lgmyhsdtnt rssrsiastl 121 kddspsvcse deisnsssqk snaqdetpia ykksahskds llpsrsssls ppqsrcstgt 181 tlekslntsg isnssgtnnn nsnnnndneq kqrnvihlns enydttvfkt gwvnkshgqt 241 vatnynssmt apssssssss qnlrndaysr nresrfygnd gsslknddss sttatnsgnd 301 vasarssmai dpqmlvpdyr lyraqlkgcv lnlyksglns nikffdptlp asnssianen 361 hqqkkqqtnn qaqaealhqk qsfgqmgepi tldlkylsev yphpdlrqds dgkiisgtie 421 slchtvlfyp gpkqsdvpne kslskthrav inlllmfpll dhfikflkvf nqfglsftkn 481 ksrltnnstq fynispavdd smtqrlalta ktildvfpgf lldepmlkti islldtislh 541 ndeisnnlki kiankhnelm kltaftrslp matssthele iildpshfls ldittladev 601 hhinlkfdkv wapkfdysll ydskfinrri vslnplvfnn dqnihflgrl lishlfptnp 661 efskkvtpkv raelldkwvq igcrfehlgd mvswlavati icsipvlrss swkyvpdqsl 721 ktifkdwvpt iiqlerrqrt skstssvfil appnldddft ranvisyfgd llihaddlps 781 dtkfkylekk inrtknafhk wqqrlqaids trhktnsten vrdndspnnv vyqlwkfhls 841 qpplniegim klsvqheppi idqkaystig sqrsalvtgs ylpilfnelf pnyslfpknt 901 lvgaasdakl ppprssarls kslsisepip iasnshtmgs ltddamsskn dnnkvtgvgk 961 idgpvikems skqsnkqrll ksvrdvfnid mdvfhisdel vfksvydndg ksrpasmvie 1021 tpkrfsqhss mlinnpatpn qkmrdsldtt grlsktlenm dffnnigqvs dslkesiirv 1081 vlksssleki fdllvltsni fsklvdtkdl enyyyhqrqr ghstrglsdd niglldyafv 1141 kltmdndift etffntyksf tttttvlenm akryvgaksc svsiskildr sddskmkine 1201 dtnlvsssly dqnfpvwdmk vtddeninli ymakiqigaa eailhlvknh ysdftddlcn 1261 nstlldiiki meqevstewp triansklqk slpenfviet enllttltdl fhgiksayqk 1321 qlyrpigvnr tqkritdiln sfntfsftdl nniiddpsfs ddmirsfqkl hstnyedile 1381 wiyqldnfis kkfnlvskkd wivlfqelel lskeslvsff nyplhfkssk linpgylqlh 1441 efeisnlftw istlilkddn gteslffekl pqsikllikl htslttffvm eisnvnksss 1501 erlttckvil qilnyirwkn gsldlfdsee desphaicph ipafietaia haiispesrn 1561 yelswikase klsdptkgtq nlrsisnvle kiddihikrf ieiddvfskn cknlcpcpgw 1621 fisrlleisq fvpnmsitns klinfdkrrf vnniisnvld lipnerefpl diemsdenps 1681 krttfgrilf nnfedvnkvy rkktkkvses eaiserfqeq gvfneilvne iekikreark 1741 levlldqeki lknsaalhqa vpkknrksvi isgthsdndh syninkntgq tpslgsvmes 1801 nnsarnrrds rasfstnrss vvsnsshngv skkiggffrr pfsiggfnts ssnyslnsil 1861 sqevssnksi lpsilpevds mqlhdlkpsy slktfeiksi meiinhrnip ayyyafkivm 1921 qngheyliqt asssdltewi kmikaskrfs fhskkykgkt hnkifgvple dvcerentli 1981 ptivvkllee ielrgldevg lyripgsigs inalknafde egatdnsftl eddrwfevna 2041 iagcfkmylr elpdslfsha mvndftdlai kykahamvne eykrmmnell qklptcyyqt 2101 lkrivfhlnk vhqhvvnnkm dasnlaivfs msfinqedla nsmgsrlgav qtilqdfikn 2161 pndyfkq // LOCUS NP_011083 338 aa linear PLN 30-JUN-2025 DEFINITION Myg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011083 VERSION NP_011083.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179046.3 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07817. On Jul 30, 2012 this sequence version replaced NP_011083.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..338 /product="Myg1p" /calculated_mol_wt="38043" Region 16..337 /region_name="UPF0160" /note="Uncharacterized protein family (UPF0160); pfam03690" /db_xref="CDD:461014" CDS 1..338 /gene="MYG1" /locus_tag="YER156C" /coded_by="NM_001179046.3:1..1017" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:31323700]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:31323700]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:1901857 positive regulation of cellular respiration [PMID:31081026]" /note="Protein involved in mitochondrial function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; role in preventing L-A mycovirus pathogenesis; human homolog MYG1 is linked to developmental processes and dermatological diseases, complements yeast null mutant" /db_xref="GeneID:856900" /db_xref="SGD:S000000958" ORIGIN 1 mnsvkrvkln skmskqicth sgsfhadesl avymlrllpe fkdaklvrsr npkdweasdi 61 lvdvgaqydg vkffdhhqrg ffetfnekyk tklssaglif khygrdiikt ilnnkvsssd 121 ldllydkvyk qfvealdand ngiskytipk dsnlepnfrd naisipgiis gmnpnwnedt 181 sdesfdrcfa rasefiggvf vtlvrgygqs wlpakalvaq aidermdvdk sgkiivlpqf 241 cpwkehlyel erekniekqi efvlftdssg awrvstvpin stsfqfrrgl peplrglrde 301 elstksgvpg cifihaagfi ggakskeavy elakmsla // LOCUS NP_011084 801 aa linear PLN 30-JUN-2025 DEFINITION Golgi transport complex subunit COG3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011084 VERSION NP_011084.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179047.1 REFERENCE 1 (residues 1 to 801) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 801) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 801) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 801) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 801) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 801) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 801) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 801) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 801) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07818. Method: conceptual translation. FEATURES Location/Qualifiers source 1..801 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..801 /product="Golgi transport complex subunit COG3" /calculated_mol_wt="92413" Region 86..232 /region_name="Sec34" /note="Sec34-like family; pfam04136" /db_xref="CDD:461190" CDS 1..801 /gene="COG3" /locus_tag="YER157W" /gene_synonym="GRD20; SEC34" /coded_by="NM_001179047.1:1..2406" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10512869]" /experiment="EXISTENCE:mutant phenotype:GO:0000301 retrograde transport, vesicle recycling within Golgi [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20065092]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20065092]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /experiment="EXISTENCE:mutant phenotype:GO:0140312 cargo adaptor activity [PMID:15229219]" /note="Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" /db_xref="GeneID:856901" /db_xref="SGD:S000000959" ORIGIN 1 marsrknslv rdiashptip esqtivglld dsylfdklkk lslavensds lqrtdvsegc 61 sevngseatt sadvkktnky lyyttyldql nikideykvv ldqtrqvndq ldssikkfrk 121 isqdtgafie etktiyekqs klsnltesip kalhyfevld pimrrlnhat spaivkkssf 181 ttmlatides lrfldensdl kdaaayrikf kqcliracel ishfltnllk qtnqeildkt 241 knknsltglp sttrdaflys kfytiadtfk iqvseivkrs nekaynkyhd elnsilyecf 301 nhyfqtrlrl ltpviwshid eivvkdkdqg lvkfiqdgkv yfqqlcadey klfveffpek 361 ecrfkinqwf lqlceplyds irvrvlketd ictlcdsvtl fapyyefeeg seeyvkqftd 421 iqydklfepi vqkvqarlil rvqiyvqqni lsyrptrdvf misnrrrksk tslqggneda 481 ttsddnpdpl lesylssfkn rsilpispnd addksidsee stdkisqlqt yyppllktla 541 llskiyemin svvfddlahh vvhdcivslr naydmvikss agksdfnnld islaylknll 601 mlrdsiqnfn iqytvnetyl dfsgvegffk slkengrnvl kktksssilt larelvpkvv 661 nnmvdartel iselrnvikd ftestsleli ddtldinsde dllsknvklr enikarlpri 721 yeqilnyidd qeivtnllda vqelitqsys kyyetitela engkfakdqv advmyldvft 781 dffakevadl lrngdidtit k // LOCUS NP_011085 573 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER158C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011085 VERSION NP_011085.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179048.1 REFERENCE 1 (residues 1 to 573) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 573) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 573) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 573) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07819. Method: conceptual translation. FEATURES Location/Qualifiers source 1..573 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..573 /product="uncharacterized protein" /calculated_mol_wt="63581" CDS 1..573 /locus_tag="YER158C" /coded_by="NM_001179048.1:1..1722" /note="hypothetical protein; potentially phosphorylated by Cdc28p; YER158C has a paralog, AFR1, that arose from the whole genome duplication" /db_xref="GeneID:856903" /db_xref="SGD:S000000960" ORIGIN 1 mlqqgsssrr slhgndfhtl tspsrrdsls ipravdarsa stidlfyipd atvsrrhstl 61 vanrsdnngn gapmrqynkp nfassstssl pstrnrpsry dnmnmnmnmn mnmnmnmnmn 121 mnnhttsdhn ahpqyrcrpn psrrhslmti pekysgsrys lrsspptysn prvrkeltpf 181 qlqrkqmksa fqfpngenft prnqiarlpp sstfpdspss sslpltqtgg pssadndsia 241 tgtnnrspqq tkaadanqks esespkairs nskkisrffr kiwsskssns adsveenskt 301 kqkrknperv vpepitsldq pveiikqsfs tvnnhetavp sikdsgivqe ltalgdnnri 361 pvlppprspn rptlsdkrtt klyycsqdss nediapeeks tvflkrlqde wstvylnklp 421 ltasvpssls tttdaanssf inssisspap ssssssslvs rgpmqsisss ptpapssgss 481 ksknavkslr fadeiyvndt wsaadycrcd ntflnnffkg ksqditnpst fvgnnlsstk 541 nisnieikme vnefkrkemr vhqdsakyth yyl // LOCUS NP_011086 142 aa linear PLN 30-JUN-2025 DEFINITION negative cofactor 2 transcription regulator complex subunit BUR6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011086 VERSION NP_011086.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179049.3 REFERENCE 1 (residues 1 to 142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 142) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07820. On Jul 30, 2012 this sequence version replaced NP_011086.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..142 /product="negative cofactor 2 transcription regulator complex subunit BUR6" /calculated_mol_wt="15386" Region 25..142 /region_name="BUR6" /note="Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]; COG5247" /db_xref="CDD:227572" CDS 1..142 /gene="BUR6" /locus_tag="YER159C" /gene_synonym="NCB1" /coded_by="NM_001179049.3:1..429" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8948634|PMID:9023340|PMID:9096360]" /experiment="EXISTENCE:direct assay:GO:0001046 core promoter sequence-specific DNA binding [PMID:18703679]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18703679]" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:12237409]" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9023340]" /experiment="EXISTENCE:direct assay:GO:0017054 negative cofactor 2 complex [PMID:8948634]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12237409]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10713169]" /experiment="EXISTENCE:genetic interaction:GO:0003714 transcription corepressor activity [PMID:10713169]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10713169]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:10713169]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:18048413]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:18048413]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:18048413]" /experiment="EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:9096360]" /experiment="EXISTENCE:physical interaction:GO:0017054 negative cofactor 2 complex [PMID:9023340]" /note="Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1" /db_xref="GeneID:856904" /db_xref="SGD:S000000961" ORIGIN 1 madqvpvttq lppikpehev pldaggspvg nmgtnsnnnn elgdvfdrik thfppakvkk 61 imqtdedigk vsqatpviag rsleffiall vkksgemarg qgtkritaei lkktilndek 121 fdflreglcv eegqtqpeee sa // LOCUS NP_011087 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011087 VERSION NP_011087.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179050.4 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07821. On Jul 30, 2012 this sequence version replaced NP_011087.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198439" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region <907..1163 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YER160C" /coded_by="join(NM_001179050.4:1..1302, NM_001179050.4:1304..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:856906" /db_xref="SGD:S000000962" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqqsn dlniesdhdf qsdielhpeq lrnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis diestgsggm 1021 hrldvpllap msqsnthess haskskdfrh sdsysdnetn htnvpisstg gtnnktvpqt 1081 seqetekrii hrspsidtss sesnslhhvv piktsdtcpk enteesiiad lplpdlppep 1141 ptelsdsfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky iqayhkevnq 1261 llkmktwdtd ryydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydpgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqq eleleeddyk mkvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsk qvldmtyeli qfiwntrdkq liwhkskpvk ptnklvvisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlshlv qelnkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_058156 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058156 VERSION NP_058156.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184429.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07822. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..440 /product="gag protein" /calculated_mol_wt="48998" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YER159C-A" /coded_by="NM_001184429.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:856907" /db_xref="SGD:S000007403" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_011088 333 aa linear PLN 30-JUN-2025 DEFINITION Spt2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011088 VERSION NP_011088.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179051.1 REFERENCE 1 (residues 1 to 333) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 333) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 333) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 333) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07823. Method: conceptual translation. FEATURES Location/Qualifiers source 1..333 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..333 /product="Spt2p" /calculated_mol_wt="38420" Region 218..330 /region_name="SPT2" /note="SPT2 chromatin protein; pfam08243" /db_xref="CDD:462407" CDS 1..333 /gene="SPT2" /locus_tag="YER161C" /gene_synonym="EXA1; SIN1" /coded_by="NM_001179051.1:1..1002" /experiment="EXISTENCE:direct assay:GO:0000217 DNA secondary structure binding [PMID:15563464]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:2072912]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:2072912]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:genetic interaction:GO:0140673 transcription elongation-coupled chromatin remodeling [PMID:16449659]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17526727]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:19057669|PMID:16449659]" /note="Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components; relocalizes to the cytosol in response to hypoxia; similar to mammalian HMG1 proteins" /db_xref="GeneID:856908" /db_xref="SGD:S000000963" ORIGIN 1 msflsklsqi rksttaskaq vqdplpkknd eeysllpkny irdedpavkr lkelrrqell 61 kngalakksg vkrkrgtssg sekkkiernd ddegglgirf krsigashap lkpvvrkkpe 121 pikkmsfeel mkqaennekq ppkvkssepv tkerphfnkp gfksskrpqk kaspgatlrg 181 vssggnsiks sdspkpvkln lptngfaqpn rrlkeklesr kqksryqddy deedndmddf 241 ieddedegyh skskhsngpg ydrdeiwamf nrgkkrseyd ydeledddme anemeileee 301 emarkmarle dkreeawlkk heeekrrrkk gir // LOCUS NP_011089 754 aa linear PLN 30-JUN-2025 DEFINITION Rad4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011089 VERSION NP_011089.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179052.4 REFERENCE 1 (residues 1 to 754) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 754) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 754) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 754) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07824. On Jul 30, 2012 this sequence version replaced NP_011089.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..754 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..754 /product="Rad4p" /calculated_mol_wt="87043" Region 1..669 /region_name="RAD4" /note="DNA repair protein RAD4 [DNA replication, recombination, and repair]; COG5535" /db_xref="CDD:227822" CDS 1..754 /gene="RAD4" /locus_tag="YER162C" /coded_by="NM_001179052.4:1..2265" /experiment="EXISTENCE:direct assay:GO:0000111 nucleotide-excision repair factor 2 complex [PMID:7768886]" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:9813069|PMID:9837874]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19889839]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:19889839]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:27035942]" /experiment="EXISTENCE:direct assay:GO:1990165 single-strand break-containing DNA binding [PMID:27035942]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:26150418]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:18936173]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:19889839]" /note="Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2; recognizes and binds damaged DNA with Rad23p during nucleotide excision repair (NER); also involved with Rad23p in turnover of ubiquitylated proteins; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage; RAD4 and RAD51 pathways confer resistance to benzo[a]pyrene dihydrodiol" /db_xref="GeneID:856909" /db_xref="SGD:S000000964" ORIGIN 1 mnedlpkeyf elirkalnek eaekaplsrr rrvrrknqpl pdakkkfktg lnelpresvv 61 tvnldssddg vvtvptddsv eeiqsseedy dseefedvtd gnevagvedi sveikpsskr 121 nsdarrtsrn vcsneerkrr kyfhmlylvc lmvhgfirne winskrlsrk lsnlvpekvf 181 ellhpqkdee lplrstrkll dglkkcmelw qkhwkitkky dnvglymrtw keiemsannk 241 rkfktlkrsd flravskghg dpdisvqgfv amlracnvna rlimscqppd ftnmkidtsl 301 ngnnaykdmv kypifwcevw dkfskkwitv dpvnlktieq vrlhsklapk gvaccernml 361 ryviaydrky gcrdvtrrya qwmnskvrkr ritkddfgek wfrkvitalh hrkrtkiddy 421 edqyffqrde segipdsvqd lknhpyyvle qdikqtqivk pgckecgylk vhgkvgkvlk 481 vyakrdiadl ksarqwymng rilktgsrck kvikrtvgrp kgeaeeeder lysfedtely 541 ipplasasge itkntfgnie vfaptmipgn cclvenpvai kaarflgvef apavtsfkfe 601 rgstvkpvls givvakwlre aietaidgie fiqeddnrke hllgaleswn tlllklrirs 661 klnstygkia eeepnvtkeq niadnhdnte tfmgggflpg ianhearpys epsepedsld 721 yvsvdkaees atdddvgedy sdfmkelems eesd // LOCUS NP_011090 232 aa linear PLN 30-JUN-2025 DEFINITION gamma-glutamylcyclotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011090 VERSION NP_011090.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179053.3 REFERENCE 1 (residues 1 to 232) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 232) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 232) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 232) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07825. On Jul 30, 2012 this sequence version replaced NP_011090.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..232 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..232 /product="gamma-glutamylcyclotransferase" /EC_number="4.3.2.7" /calculated_mol_wt="26162" Region 8..231 /region_name="ChaC" /note="ChaC-like protein; pfam04752" /db_xref="CDD:398428" Site order(60..61,87,119..123,125) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:119400" Site 115 /site_type="active" /note="putative catalytic residue [active]" /db_xref="CDD:119400" CDS 1..232 /gene="GCG1" /locus_tag="YER163C" /coded_by="NM_001179053.3:1..699" /experiment="EXISTENCE:direct assay:GO:0003839 gamma-glutamylcyclotransferase activity [PMID:23070364]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006751 glutathione catabolic process [PMID:23070364]" /experiment="EXISTENCE:mutant phenotype:GO:0006751 glutathione catabolic process [PMID:23070364]" /note="Gamma-glutamyl cyclotransferase; cleaves the gamma-glutamyl bond of glutathione to yield 5-oxoproline and a Cys-Gly dipeptide; similar to mammalian pro-apoptotic protein ChaC1; expression of mouse ChaC1 in yeast increases apoptosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle" /db_xref="GeneID:856910" /db_xref="SGD:S000000965" ORIGIN 1 mtndnsgiwv lgygsliykp pshythripa iihgfarrfw qsstdhrgtp anpgrvatli 61 pyediirqta flknvnlyse sapiqdpddl vtigvvyyip pehaqevrey lnvreqngyt 121 lhevevhlet nreheaelge aleqlprhnk sgkrvlltsv yigtidneaf vgpetvdeta 181 kviavshgps gsnyeylakl eqalaqmpim kergritdhy ltalletvnk yr // LOCUS NP_011091 1468 aa linear PLN 30-JUN-2025 DEFINITION chromatin-remodeling ATPase CHD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011091 VERSION NP_011091.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179054.1 REFERENCE 1 (residues 1 to 1468) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1468) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1468) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1468) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07826. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1468 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1468 /product="chromatin-remodeling ATPase CHD1" /calculated_mol_wt="168111" Region 175..247 /region_name="CD1_tandem_CHD1_yeast_like" /note="repeat 1 of the paired tandem chromodomains of yeast chromodomain helicase DNA-binding protein 1, and similar proteins; cd18665" /db_xref="CDD:349312" Site order(177,217,219..220,224) /site_type="other" /note="peptide binding site [polypeptide binding]" /db_xref="CDD:349312" Region 283..341 /region_name="CD2_tandem_ScCHD1_like" /note="repeat 2 of the paired tandem chromodomains of yeast chromodomain helicase DNA-binding protein 1, and similar proteins; cd18664" /db_xref="CDD:349311" Site order(306,323) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:349311" Region 363..>961 /region_name="PLN03142" /note="Probable chromatin-remodeling complex ATPase chain; Provisional" /db_xref="CDD:215601" Region 1010..1129 /region_name="Cdh1_DBD_1" /note="Chromodomain helicase DNA-binding domain 1; pfam18196" /db_xref="CDD:408024" Region 1175..>1204 /region_name="SANT_TRF" /note="Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; cd11660" /db_xref="CDD:212558" Region 1368..1460 /region_name="DUF4208" /note="Domain of unknown function (DUF4208); pfam13907" /db_xref="CDD:464035" CDS 1..1468 /gene="CHD1" /locus_tag="YER164W" /coded_by="NM_001179054.1:1..4407" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:15647753]" /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:17259992]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12682017|PMID:12504018]" /experiment="EXISTENCE:direct assay:GO:0000976 transcription cis-regulatory region binding [PMID:23468649]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:21623345]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:33174727|PMID:10811623]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:10811623]" /experiment="EXISTENCE:direct assay:GO:0030874 nucleolar chromatin [PMID:17259992]" /experiment="EXISTENCE:direct assay:GO:0031490 chromatin DNA binding [PMID:12682017]" /experiment="EXISTENCE:direct assay:GO:0035861 site of double-strand break [PMID:34520455]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:15647753]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:15647753]" /experiment="EXISTENCE:direct assay:GO:0140658 ATP-dependent chromatin remodeler activity [PMID:33174727|PMID:10811623]" /experiment="EXISTENCE:genetic interaction:GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter [PMID:19948887]" /experiment="EXISTENCE:genetic interaction:GO:0006363 termination of RNA polymerase I transcription [PMID:17259992]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:12682017]" /experiment="EXISTENCE:genetic interaction:GO:0006369 termination of RNA polymerase II transcription [PMID:12504018]" /experiment="EXISTENCE:genetic interaction:GO:0140750 nucleosome array spacer activity [PMID:21940898|PMID:26861626]" /experiment="EXISTENCE:genetic interaction:GO:2000104 negative regulation of DNA-templated DNA replication [PMID:18245327]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:34520455]" /experiment="EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:34520455]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:12504018]" /experiment="EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:31222142]" /experiment="EXISTENCE:mutant phenotype:GO:0034728 nucleosome organization [PMID:10811623]" /experiment="EXISTENCE:mutant phenotype:GO:0140750 nucleosome array spacer activity [PMID:26861626]" /experiment="EXISTENCE:mutant phenotype:GO:1902275 regulation of chromatin organization [PMID:22922743]" /experiment="EXISTENCE:physical interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:12682017]" /note="Chromatin remodeler that regulates various aspects of transcription; acts in conjunction with Isw1b to regulate chromatin structure, maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; component of both SAGA and SLIK complexes; ATPase motor stimulates DNA unwrapping from nucleosomes; contains two chromodomains, a helicase domain and a DNA-binding domain; human ortholog CHD1 is a prostate cancer tumor suppressor" /db_xref="GeneID:856911" /db_xref="SGD:S000000966" ORIGIN 1 maakdistev lqnpelyglr rshraaahqq nyfndsdded dednikqsrr krmttiedde 61 defedeegee dsgededeed feedddyygs pikqnrskpk srtksksksk pksqsekqst 121 vkiptrfsnr qnktvnynid ysdddllese ddygseeals eenvheasan pqpedfhgid 181 ivinhrlkts leegkvlekt vpdlnncken yeflikwtde shlhntwety esigqvrglk 241 rldnyckqfi iedqqvrldp yvtaedieim dmererrlde feefhvperi idsqrasled 301 gtsqlqylvk wrrlnydeat wenatdivkl apeqvkhfqn renskilpqy ssnytsqrpr 361 feklsvqppf ikggelrdfq ltginwmafl wskgdngila demglgktvq tvafiswlif 421 arrqngphii vvplstmpaw ldtfekwapd lncicymgnq ksrdtireye fytnprakgk 481 ktmkfnvllt tyeyilkdra elgsikwqfm avdeahrlkn aesslyesln sfkvanrmli 541 tgtplqnnik elaalvnflm pgrftidqei dfenqdeeqe eyihdlhrri qpfilrrlkk 601 dvekslpskt erilrvelsd vqteyyknil tknysaltag akgghfslln imnelkkasn 661 hpylfdnaee rvlqkfgdgk mtrenvlrgl imssgkmvll dqlltrlkkd ghrvlifsqm 721 vrmldilgdy lsikginfqr ldgtvpsaqr risidhfnsp dsndfvflls tragglginl 781 mtadtvvifd sdwnpqadlq amarahrigq knhvmvyrlv skdtveeevl erarkkmile 841 yaiislgvtd gnkytkknep nagelsailk fgagnmftat dnqkkledln lddvlnhaed 901 hvttpdlges hlggeeflkq fevtdykadi dwddiipeee lkklqdeeqk rkdeeyvkeq 961 lemmnrrdna lkkiknsvng dgtaansdsd ddstsrssrr rarandmdsi gesevralyk 1021 ailkfgnlke ildeliadgt lpvksfekyg etydemmeaa kdcvheeekn rkeileklek 1081 hatayraklk sgeikaenqp kdnpltrlsl kkrekkavlf nfkgvkslna esllsrvedl 1141 kylknlinsn ykddplkfsl gnntpkpvqn wssnwtkeed eklligvfky gygswtqird 1201 dpflgitdki flnevhnpva kksasssdtt ptpskkgkgi tgsskkvpga ihlgrrvdyl 1261 lsflrgglnt kspsadigsk klptgpskkr qrkpanhsks mtpeitssep angppskrmk 1321 alpkgpaali nntrlspnsp tpplkskvsr dngtrqssnp ssgsahekey dsmdeedcrh 1381 tmsairtslk rlrrggksld rkewakilkt elttignhie sqkgssrkas pekyrkhlws 1441 ysanfwpadv kstklmamyd kitesqkk // LOCUS NP_011092 577 aa linear PLN 30-JUN-2025 DEFINITION polyadenylate-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011092 VERSION NP_011092.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179055.1 REFERENCE 1 (residues 1 to 577) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 577) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 577) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 577) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07827. Method: conceptual translation. FEATURES Location/Qualifiers source 1..577 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..577 /product="polyadenylate-binding protein" /calculated_mol_wt="64213" Region 38..559 /region_name="PABP-1234" /note="polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628" /db_xref="CDD:130689" CDS 1..577 /gene="PAB1" /locus_tag="YER165W" /coded_by="NM_001179055.1:1..1734" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:15630021|PMID:15769879]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15630021|PMID:11914276|PMID:15769879]" /experiment="EXISTENCE:direct assay:GO:0005840 ribosome [PMID:8631901]" /experiment="EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:10357826]" /experiment="EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:9193001]" /experiment="EXISTENCE:direct assay:GO:0008428 ribonuclease inhibitor activity [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:19470581|PMID:17908917|PMID:24291094|PMID:18981231|P MID:26777405]" /experiment="EXISTENCE:direct assay:GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening [PMID:17766253]" /experiment="EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:27184763]" /experiment="EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:10357826]" /experiment="EXISTENCE:mutant phenotype:GO:0008143 poly(A) binding [PMID:9193001]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:9223284]" /experiment="EXISTENCE:mutant phenotype:GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening [PMID:17766253]" /note="Poly(A) binding protein; interacts with the cleavage factor complex CF I, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G; stimulates, but is not required for the deadenylation activity of the Pan2p-Pan3p poly(A)-ribonuclease complex; role in preventing L-A mycovirus pathogenesis" /db_xref="GeneID:856912" /db_xref="SGD:S000000967" ORIGIN 1 maditdktae qlenlniqdd qkqaatgses qsvenssasl yvgdlepsvs eahlydifsp 61 igsvssirvc rdaitktslg yayvnfndhe agrkaieqln ytpikgrlcr imwsqrdpsl 121 rkkgsgnifi knlhpdidnk alydtfsvfg dilsskiatd engkskgfgf vhfeeegaak 181 eaidalngml lngqeiyvap hlsrkerdsq leetkahytn lyvkninset tdeqfqelfa 241 kfgpivsasl ekdadgklkg fgfvnyekhe davkavealn dselngekly vgraqkkner 301 mhvlkkqyea yrlekmakyq gvnlfvknld dsvddeklee efapygtits akvmrtengk 361 skgfgfvcfs tpeeatkait eknqqivagk plyvaiaqrk dvrrsqlaqq iqarnqmryq 421 qataaaaaaa agmpgqfmpp mfygvmpprg vpfngpnpqq mnpmggmpkn gmppqfrngp 481 vygvppqggf prnandnnqf yqqkqrqalg eqlykkvsak tsneeaagki tgmildlppq 541 evfpllesde lfeqhykeas aayesfkkeq eqqteqa // LOCUS NP_011093 1571 aa linear PLN 30-JUN-2025 DEFINITION aminophospholipid-translocating P4-type ATPase DNF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011093 VERSION NP_011093.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179056.3 REFERENCE 1 (residues 1 to 1571) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1571) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1571) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1571) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07828. On Jul 30, 2012 this sequence version replaced NP_011093.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1571 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1571 /product="aminophospholipid-translocating P4-type ATPase DNF1" /EC_number="7.6.2.1" /calculated_mol_wt="177668" Region 191..1413 /region_name="ATPase-Plipid" /note="phospholipid-translocating P-type ATPase, flippase; TIGR01652" /db_xref="CDD:273734" Site order(667..669,842,871..873,942,989..991,1104,1107,1110, 1130,1133) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:319770" CDS 1..1571 /gene="DNF1" /locus_tag="YER166W" /coded_by="NM_001179056.3:1..4716" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:33060204|PMID:12221123|PMID:12631737]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0070867 mating projection tip membrane [PMID:25378585]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006886 intracellular protein transport [PMID:12221123]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:12631737]" /experiment="EXISTENCE:genetic interaction:GO:0007163 establishment or maintenance of cell polarity [PMID:15461661]" /experiment="EXISTENCE:genetic interaction:GO:0045332 phospholipid translocation [PMID:17015438|PMID:12631737]" /experiment="EXISTENCE:genetic interaction:GO:0090555 phosphatidylethanolamine flippase activity [PMID:17015438|PMID:12631737]" /experiment="EXISTENCE:genetic interaction:GO:0140345 phosphatidylcholine flippase activity [PMID:12631737]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:12631737]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:17015438]" /experiment="EXISTENCE:mutant phenotype:GO:0090555 phosphatidylethanolamine flippase activity [PMID:27432949|PMID:17015438]" /experiment="EXISTENCE:mutant phenotype:GO:0099040 ceramide translocation [PMID:33060204]" /experiment="EXISTENCE:mutant phenotype:GO:0140345 phosphatidylcholine flippase activity [PMID:27432949]" /experiment="EXISTENCE:mutant phenotype:GO:0140351 glycosylceramide flippase activity [PMID:33060204]" /experiment="EXISTENCE:physical interaction:GO:1990531 phospholipid-translocating ATPase complex [PMID:15090616]" /note="Aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to endocytosis, protein transport, and cellular polarization; localizes primarily to the plasma membrane; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone; DNF1 has a paralog, DNF2, that arose from the whole genome duplication" /db_xref="GeneID:856913" /db_xref="SGD:S000000968" ORIGIN 1 msgtfhgdgh apmspfedtf qfednssned thiapthfdd gatsnkysrp qvsfndetpk 61 nkredaeeft fnddteydnh sfqptpklnn gsgtfddvel dndsgephtn ydgmkrfrmg 121 tkrnkkgnpi mgrsktlkwa rknipnpfed ftkddidpga inraqelrtv yynmplpkdm 181 ideegnpimq yprnkirttk ytpltflpkn ilfqfhnfan vyflvliilg afqifgvtnp 241 glsavplvvi viitaikdai edsrrtvldl evnntkthil egvenenvst dnislwrrfk 301 kansrllfkf iqyckehlte egkkkrmqrk rhelrvqktv gtsgprssld sidsyrvsad 361 ygrpsldydn leqgageani vdrslpprtd ckfaknywkg vkvgdivrih nndeipadii 421 llstsdtdga cyvetknldg etnlkvrqsl kctntirtsk diartkfwie segphsnlyt 481 yqgnmkwrnl adgeirnepi tinnvllrgc tlrntkwamg vvmftggdtk imlnsgitpt 541 kksrisreln fsvvinfvll filcfvsgia ngvyydkkgr srfsyefgti agsaatngfv 601 sfwvavilyq slvpislyis veiiktaqaa fiygdvllyn akldypctpk swnisddlgq 661 veyifsdktg tltqnvmefk kctingvsyg raytealagl rkrqgidvet egrrekaeia 721 kdrdtmidel ralsgnsqfy peevtfvske fvrdlkgasg evqqrccehf mlalalchsv 781 lveanpdnpk kldlkaqspd eaalvatard vgfsfvgktk kgliiemqgi qkefeilnil 841 efnssrkrms civkipglnp gdeprallic kgadsiiysr lsrqsgsnse ailektalhl 901 eqyateglrt lciaqrelsw seyekwneky diaaaslanr edelevvads ierelillgg 961 taiedrlqdg vpdciellae agiklwvltg dkvetainig fscnllnnem ellvikttgd 1021 dvkefgseps eivdallsky lkeyfnltgs eeeifeakkd hefpkgnyai vidgdalkla 1081 lygedirrkf lllckncrav lccrvspsqk aavvklvkds ldvmtlaigd gsndvamiqs 1141 advgigiage egrqavmcsd yaigqfryla rlvlvhgrws ykrlaemipe ffyknmifal 1201 alfwygiynd fdgsylyeyt ymmfynlaft slpviflgil dqdvndtisl vvpqlyrvgi 1261 lrkewnqrkf lwymldglyq siicfffpyl vyhknmivts nglgldhryf vgvyvttiav 1321 iscntyvllh qyrwdwfsgl fialsclvvf awtgiwssai asreffkaaa riygapsfwa 1381 vffvavlfcl lprftydsfq kffyptdvei vremwqhghf dhyppgydpt dpnrpkvtka 1441 gqhgekiieg ialsdnlggs nysrdsvvte eipmtfmhge dgspsgyqkq etwmtspket 1501 qdllqspqfq qaqtfgrgps tnvrssldrt reqmiatnql dnrysverar tsldlpgvtn 1561 aasligtqqn n // LOCUS NP_011094 851 aa linear PLN 30-JUN-2025 DEFINITION Bck2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011094 VERSION NP_011094.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179057.3 REFERENCE 1 (residues 1 to 851) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 851) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 851) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 851) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 851) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 851) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 851) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 851) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 851) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07829. On Jul 30, 2012 this sequence version replaced NP_011094.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..851 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..851 /product="Bck2p" /calculated_mol_wt="93607" CDS 1..851 /gene="BCK2" /locus_tag="YER167W" /gene_synonym="CTR7" /coded_by="NM_001179057.3:1..2556" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12518319]" /experiment="EXISTENCE:mutant phenotype:GO:0010628 positive regulation of gene expression [PMID:19158491]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:7891677]" /note="Serine/threonine-rich protein involved in PKC1 signaling pathway; protein kinase C (PKC1) signaling pathway controls cell integrity; overproduction suppresses pkc1 mutations" /db_xref="GeneID:856914" /db_xref="SGD:S000000969" ORIGIN 1 mpknshhhrs ssvnstksrs testnkwkip hyyrrsasgs tqaspdrnss tgscstpvlp 61 tmnvmsspkk vlledprdnh tkakkssrkk sgemvfvnyt vqdtanendt dlqtqpvsvp 121 apkaklkkks skrrmlkifg ssknehiedi veeqpmvlqm dseskplsgt pisesgidas 181 slttkrsyns flkhnrlngk tpfsgnlsfp slnmmgnttd lpidnndfcs ekevvpksth 241 dpslakppsr ftesetnstp nlssiplmnt kntrlkynkv apqssdrqks qesglyhste 301 sfnfkdqnys nnksslslns dlstphfakh spdsprtsrs fncgdsqskv klpeendasi 361 afskmftrkr antggstcsl asptiaqtiq qsnikvnklp tqrttsvgsl ssmsnryspi 421 rvaspgrars atrgsslyrl srdlnslpsv tdlpemdstt pvneifldgq pqhksgsvkg 481 ghrkkqesis daqriqhsns yittpssslv tppyymtgyt lpssasasst pnvlethnmn 541 fvpststvts yrpssnfssf dkeysnenda sgefsafntp menipalkgi prstleenee 601 edvlvqdipn tahfqrrdim gmdthrkdds ldfnslmphg sttsssivds vmtnsisttt 661 snatgnyfqd qdkytlvntg lglsdanldh firsqwkhas rsesnnntgn rvsysgstpn 721 nvdttktnlq vytefdfenp esffheqskl lgemghsnnn snsainmnep ksadtyigni 781 spdtsatvsl gdlmgsnvsn nsernfydgh tfvpqyqans svensnnqna apianndidn 841 nlqsfyfdns n // LOCUS NP_011095 546 aa linear PLN 30-JUN-2025 DEFINITION tRNA adenylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011095 VERSION NP_011095.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179058.1 REFERENCE 1 (residues 1 to 546) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 546) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 546) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 546) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07830. Method: conceptual translation. FEATURES Location/Qualifiers source 1..546 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..546 /product="tRNA adenylyltransferase" /EC_number="2.7.7.72" /calculated_mol_wt="62354" Region 67..>293 /region_name="PcnB" /note="tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; COG0617" /db_xref="CDD:440382" CDS 1..546 /gene="CCA1" /locus_tag="YER168C" /gene_synonym="TNT1" /coded_by="NM_001179058.1:1..1641" /experiment="EXISTENCE:direct assay:GO:0001680 tRNA 3'-terminal CCA addition [PMID:1634528]" /experiment="EXISTENCE:direct assay:GO:0004810 CCA tRNA nucleotidyltransferase activity [PMID:1634528]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:1634528]" /experiment="EXISTENCE:direct assay:GO:0052927 CC tRNA cytidylyltransferase activity [PMID:23872483]" /experiment="EXISTENCE:direct assay:GO:0052929 ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity [PMID:23872483]" /note="ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites; human homolog TRNT1 complements yeast null mutant" /db_xref="GeneID:856915" /db_xref="SGD:S000000970" ORIGIN 1 mlrstisllm nsaaqktmtn snfvlnapki tltkveqnic nllndytdly nqkyhnkpep 61 ltlritggwv rdkllgqgsh dldiainvms geqfatglne ylqqhyakyg akphnihkid 121 knpekskhle tattklfgve vdfvnlrsek ytelsripkv cfgtpeedal rrdatlnalf 181 ynihkgeved ftkrglqdlk dgvlrtplpa kqtflddplr vlrlirfasr fnftidpevm 241 aemgdpqinv afnskisrer vgvemekilv gptpllalql iqrahlenvi ffwhndssvv 301 kfneencqdm dkinhvyndn ilnshlksfi elypmflekl pilrekigrs pgfqqnfils 361 ailspmanlq iignpkkkin nlvsvtesiv keglklsknd aaviaktvds icsyeeilak 421 fadrsqlkks eigiflrnfn gewetahfas lsdaflkipk letkkiellf qnynefysyi 481 fdnnlnnche lkpivdgkqm akllqmkpgp wlgkinneai rwqfdnptgt dqelithlka 541 ilpkyl // LOCUS NP_011096 796 aa linear PLN 30-JUN-2025 DEFINITION Rph1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011096 VERSION NP_011096.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179059.1 REFERENCE 1 (residues 1 to 796) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 796) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 796) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 796) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07831. Method: conceptual translation. FEATURES Location/Qualifiers source 1..796 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..796 /product="Rph1p" /calculated_mol_wt="90081" Region 13..54 /region_name="JmjN" /note="Small domain found in the jumonji family of transcription factors; smart00545" /db_xref="CDD:128818" Region 222..338 /region_name="JmjC" /note="JmjC domain, hydroxylase; pfam02373" /db_xref="CDD:396791" Region 507..>759 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 711..732 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 740..757 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..796 /gene="RPH1" /locus_tag="YER169W" /gene_synonym="KDM4" /coded_by="NM_001179059.1:1..2391" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10523651]" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10523651]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10523651]" /experiment="EXISTENCE:direct assay:GO:0032454 histone H3K9 demethylase activity [PMID:17371840]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:21296759|PMID:19111667]" /experiment="EXISTENCE:direct assay:GO:0051864 histone H3K36 demethylase activity [PMID:17369256|PMID:17525156|PMID:17371840]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:25660547]" /experiment="EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:25660547]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:17525156]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:25660547]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10523651]" /experiment="EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:25660547]" /experiment="EXISTENCE:mutant phenotype:GO:0043565 sequence-specific DNA binding [PMID:21296759]" /experiment="EXISTENCE:mutant phenotype:GO:0051864 histone H3K36 demethylase activity [PMID:17371840|PMID:17369256|PMID:17525156]" /note="JmjC domain-containing histone demethylase; targets tri- and dimethylated H3K36; associates with actively transcribed regions and promotes elongation; repressor of autophagy-related genes in nutrient-replete conditions; damage-responsive repressor of PHR1; phosphorylated by the Rad53p-dependent DNA damage checkpoint pathway and by a Rim1p-mediated event during starvation; target of stress-induced hormesis; RPH1 has a paralog, GIS1, that arose from the whole genome duplication" /db_xref="GeneID:856916" /db_xref="SGD:S000000971" ORIGIN 1 mtkliapsei vggvpvfkpt yeqfedfyay ckainkygmk sgvvkvippk ewkdkldlpy 61 saetlqkiki kspiqqhisg nkglfmvqnv eknktyniiq wkdlskdyvp pedpkarrns 121 rkgsvskstk lklknfessf niddfeqfrt eytidlsdfq nterlkflee yywktlnftt 181 pmygadtpgs ifpeglnvwn vaklpnildh metkvpgvnd sylyaglwka sfswhledqd 241 lysinyihfg apkqwysipq edrfkfykfm qeqfpeeakn cpeflrhkmf laspkllqen 301 gircneivhh egefmitypy gyhagfnygy nlaesvnfal eewlpigkka gkchcisdsv 361 eidvkklaks wrdnnkeskg tpplnqlpnp ampllhrptl kemessslrs tspdvghfsn 421 fkskssgvss pllsrmkdys niveptledp tlklkrissf qeqplnkllk retsqtamlt 481 dhednivams ltsmansaas sprlplsrln ssnelsnaqp lldmtnntla fprpngpsgl 541 npllyisnkn isgishsaph spvnpnisli krvkspnivt lnisressrs pialnyearq 601 qhsqqhsfst pstvsnlsts vlgplsdtnd iktphperpn hktanrilkk espvetsksn 661 lilskvastr qedsftsrnd dldkeqgssp lnskfapeei vlsgknkiyi ckecqrkfss 721 ghhltrhkks vhsgekphsc pkcgkrfkrr dhvlqhlnkk ipcisnettv dapimnptvq 781 pqdgkaainq qstpln // LOCUS NP_011097 225 aa linear PLN 30-JUN-2025 DEFINITION adenylate kinase ADK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011097 VERSION NP_011097.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179060.3 REFERENCE 1 (residues 1 to 225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 225) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07832. On Jul 30, 2012 this sequence version replaced NP_011097.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..225 /product="adenylate kinase ADK2" /EC_number="2.7.4.10" /calculated_mol_wt="25063" Region 21..216 /region_name="adk" /note="adenylate kinase; Reviewed; PRK00279" /db_xref="CDD:234711" CDS 1..225 /gene="ADK2" /locus_tag="YER170W" /gene_synonym="AKY3; PAK3" /coded_by="NM_001179060.3:1..678" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15753074|PMID:8537371]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8537371]" /experiment="EXISTENCE:direct assay:GO:0009117 nucleotide metabolic process [PMID:15753074]" /experiment="EXISTENCE:direct assay:GO:0046899 nucleoside triphosphate adenylate kinase activity [PMID:15753074|PMID:8537371]" /note="Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background" /db_xref="GeneID:856917" /db_xref="SGD:S000000972" ORIGIN 1 mkadakqith llkplrllll gapgsgkgtq tsrllkqipq lssissgdil rqeiksestl 61 greattyiaq gkllpddlit rlitfrlsal gwlkpsamwl ldgfprttaq asaldellkq 121 hdaslnlvve ldvpestile rienryvhvp sgrvynlqyn ppkvpglddi tgepltkrld 181 dtaevfkkrl eeykktnepl kdyykksgif gtvsgetsdi ifrny // LOCUS NP_011098 778 aa linear PLN 30-JUN-2025 DEFINITION TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011098 VERSION NP_011098.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179061.3 REFERENCE 1 (residues 1 to 778) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 778) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 778) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 778) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 778) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 778) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 778) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 778) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 778) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07833. On Jul 30, 2012 this sequence version replaced NP_011098.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..778 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..778 /product="TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3" /EC_number="5.6.2.3" /calculated_mol_wt="89655" Region 7..717 /region_name="rad3" /note="DNA repair helicase (rad3); TIGR00604" /db_xref="CDD:273169" CDS 1..778 /gene="RAD3" /locus_tag="YER171W" /gene_synonym="REM1" /coded_by="NM_001179061.3:1..2337" /experiment="EXISTENCE:direct assay:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:8855246]" /experiment="EXISTENCE:direct assay:GO:0000439 transcription factor TFIIH core complex [PMID:19818408|PMID:14500720]" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:8132553]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:2957691]" /experiment="EXISTENCE:direct assay:GO:0043139 5'-3' DNA helicase activity [PMID:2827162]" /experiment="EXISTENCE:mutant phenotype:GO:0000019 regulation of mitotic recombination [PMID:10713167|PMID:9799251]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:7026973]" /experiment="EXISTENCE:mutant phenotype:GO:0045951 positive regulation of mitotic recombination [PMID:24189665]" /note="5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856918" /db_xref="SGD:S000000973" ORIGIN 1 mkfyiddlpv lfpypkiype qynymcdikk tldvggnsil empsgtgktv sllsltiayq 61 mhypehrkii ycsrtmseie kalvelenlm dyrtkelgyq edfrglglts rknlclhpev 121 skerkgtvvd ekcrrmtngq akrkleedpe anvelceyhe nlynievedy lpkgvfsfek 181 llkyceektl cpyfivrrmi slcniiiysy hylldpkiae rvsnevskds ivifdeahni 241 dnvcieslsl dlttdalrra trganalder isevrkvdsq klqdeyeklv qglhsadilt 301 dqeepfvetp vlpqdlltea ipgnirraeh fvsflkrlie ylktrmkvlh visetpksfl 361 qhlkqltfie rkplrfcser lsllvrtlev tevedftalk diatfatlis tyeegfllii 421 epyeienaav pnpimrftcl dasiaikpvf erfssviits gtispldmyp rmlnfktvlq 481 ksyamtlakk sflpmiitkg sdqvaissrf eirndpsivr nygsmlvefa kitpdgmvvf 541 fpsylymesi vsmwqtmgil devwkhklil vetpdaqets laletyrkac sngrgaills 601 vargkvsegi dfdhqygrtv lmigipfqyt esrilkarle fmrenyrire ndflsfdamr 661 haaqclgrvl rgkddygvmv ladrrfsrkr sqlpkwiaqg lsdadlnlst dmaisntkqf 721 lrtmaqptdp kdqegvsvws yedlikhqns rkdqggfien enkegeqded edediemq // LOCUS NP_011099 2163 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase BRR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011099 VERSION NP_011099.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179062.1 REFERENCE 1 (residues 1 to 2163) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2163) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 2163) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2163) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 2163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 2163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07834. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2163 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..2163 /product="ATP-dependent RNA helicase BRR2" /EC_number="3.6.4.13" /calculated_mol_wt="246055" Region 281..389 /region_name="Helicase_PWI" /note="N-terminal helicase PWI domain; pfam18149" /db_xref="CDD:436309" Region 480..695 /region_name="DEXHc_Brr2_1" /note="N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; cd18019" /db_xref="CDD:350777" Region 498..1034 /region_name="BRR2" /note="Replicative superfamily II helicase [Replication, recombination and repair]; COG1204" /db_xref="CDD:440817" Site order(498,500,503,524..528,634..635) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350777" Site order(563..565,591..595,597..598,608,610..611,614,618,643) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:350777" Region 998..1307 /region_name="Sec63" /note="Sec63 Brl domain; pfam02889" /db_xref="CDD:460740" Region 1338..1870 /region_name="BRR2" /note="Replicative superfamily II helicase [Replication, recombination and repair]; COG1204" /db_xref="CDD:440817" Region 1345..1536 /region_name="DEXHc_Brr2_2" /note="C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; cd18021" /db_xref="CDD:350779" Site order(1345,1347..1349,1352,1371..1377) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350779" Region 1843..2161 /region_name="SEC63" /note="Domain of unknown function in Sec63p, Brr2p and other proteins; smart00611" /db_xref="CDD:214744" CDS 1..2163 /gene="BRR2" /locus_tag="YER172C" /gene_synonym="PRP44; RSS1; SLT22; SNU246" /coded_by="NM_001179062.1:1..6492" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:8649518]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:8670905|PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:mutant phenotype:GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [PMID:9705931]" /experiment="EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:9705931|PMID:8649518]" /note="RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD" /db_xref="GeneID:856919" /db_xref="SGD:S000000974" ORIGIN 1 mtehetkdka kkireiyryd emsnkvlkvd krfmntsqnp qrdaeisqpk smsgrisakd 61 mgqglcnnin kglkendvav ektgksaslk kiqqhntiln sssdfrlhyy pkdpsnvety 121 eqilqwvtev lgndiphdli igtadifirq lkeneenedg nieerkekiq helginidsl 181 kfnelvklmk nitdyethpd nsnkqavail addeksdeee vtemsnnanv lggeindned 241 ddeeydyndv evnskkknkr alpniendii klsdsktsni esvpiyside fflqrklrse 301 lgykdtsviq dlsekilndi etlehnpval eqklvdllkf enislaefil knrstifwgi 361 rlakstenei pnliekmvak glndlveqyk fretthskre ldsgddqpqs seakrtkfsn 421 paippvidle kikfdesskl mtvtkvslpe gsfkrvkpqy deihipapsk pvidyelkei 481 tslpdwcqea fpssettsln piqskvfhaa fegdsnmlic aptgsgktni alltvlkals 541 hhynpktkkl nlsafkivyi aplkalvqeq vrefqrrlaf lgikvaeltg dsrlsrkqid 601 etqvlvstpe kwdittrnsn nlaivelvrl liideihllh ddrgpvlesi vartfwasky 661 gqeypriigl satlpnyedv grflrvpkeg lfyfdssfrp cplsqqfcgi kernslkklk 721 amndacyekv lesinegnqi ivfvhsrket srtatwlknk faeenithkl tkndagskqi 781 lkteaanvld pslrkliesg igthhagltr sdrslsedlf adgllqvlvc tatlawgvnl 841 pahtviikgt dvyspekgsw eqlspqdvlq mlgragrpry dtfgegiiit dqsnvqyyls 901 vlnqqlpies qfvsklvdnl naevvagnik crndavnwla ytylyvrmla spmlykvpdi 961 ssdgqlkkfr eslvhsalci lkeqelvlyd aendvieatd lgniassfyi nhasmdvynr 1021 eldehttqid lfrifsmsee fkyvsvryee krelkqllek apipiredid dplakvnvll 1081 qsyfsqlkfe gfalnsdivf ihqnagrllr amfeiclkrg wghptrmlln lcksattkmw 1141 ptncplrqfk tcpvevikrl eastvpwgdy lqletpaevg rairsekygk qvydllkrfp 1201 kmsvtcnaqp itrsvmrfni eiiadwiwdm nvhgslepfl lmledtdgds ilyydvlfit 1261 pdivgheftl sftyelkqhn qnnlppnffl tlisenwwhs efeipvsfng fklpkkfppp 1321 tpllenisis tselgnddfs evfefktfnk iqsqvfesly nsndsvfvgs gkgtgktama 1381 elallnhwrq nkgravyinp sgekidflls dwnkrfshla ggkiinklgn dpslnlklla 1441 kshvllatpv qfellsrrwr qrkniqslel miyddaheis qgvygavyet lisrmifiat 1501 qlekkirfvc lsnclanard fgewagmtks niynfspser iepleiniqs fkdvehisfn 1561 fsmlqmafea saaaagnrns ssvflpsrkd cmevasafmk fskaiewdml nveeeqivpy 1621 iekltdghlr aplkhgvgil ykgmasnder ivkrlyeyga vsvlliskdc safacktdev 1681 iilgtnlydg aehkympyti nellemvgla sgndsmagkv liltshnmka yykkfliepl 1741 ptesylqyii hdtlnneian siiqskqdcv dwftysyfyr rihvnpsyyg vrdtsphgis 1801 vflsnlvetc lndlvessfi eiddteaevt aevnggddea teiistlsng liashygvsf 1861 ftiqsfvssl sntstlknml yvlstavefe svplrkgdra llvklskrlp lrfpehtssg 1921 svsfkvflll qayfsrlelp vdfqndlkdi lekvvplinv vvdilsangy lnattamdla 1981 qmliqgvwdv dnplrqiphf nnkilekcke invetvydim aledeerdei ltltdsqlaq 2041 vaafvnnypn veltyslnns dslisgvkqk itiqltrdve penlqvtsek ypfdklesww 2101 lvlgevskke lyaikkvtln ketqqyelef dtptsgkhnl tiwcvcdsyl dadkelsfei 2161 nvk // LOCUS NP_011100 659 aa linear PLN 30-JUN-2025 DEFINITION Rad24p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011100 VERSION NP_011100.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179063.1 REFERENCE 1 (residues 1 to 659) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 659) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 659) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 659) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07835. Method: conceptual translation. FEATURES Location/Qualifiers source 1..659 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..659 /product="Rad24p" /calculated_mol_wt="75596" Region 1..634 /region_name="rad24" /note="checkpoint protein rad24; TIGR00602" /db_xref="CDD:129690" CDS 1..659 /gene="RAD24" /locus_tag="YER173W" /coded_by="NM_001179063.1:1..1980" /experiment="EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:12604797]" /experiment="EXISTENCE:direct assay:GO:0031389 Rad17 RFC-like complex [PMID:10660302|PMID:12604797]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:9564050]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:11267834]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511543]" /experiment="EXISTENCE:physical interaction:GO:0031389 Rad17 RFC-like complex [PMID:10660302]" /note="Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein" /db_xref="GeneID:856920" /db_xref="SGD:S000000975" ORIGIN 1 mdstnlnkrp llqyslsslg sqitkwsssr ptspvrkars tendflskqd tssilpsind 61 dggeqwyekf kpncleqvai hkrklkdvqe aldamflpna khrilllsgp sgcskstvik 121 elskilvpky rqnsngtsfr stpnehkvte frgdcivndl pqmesfsefl kgarylvmsn 181 lsliliedlp nvfhidtrrr fqqlilqwly ssepllpplv iciteceipe ndnnyrkfgi 241 dytfsaetim nkeilmhprl krikfnpins tllkkhlkfi cvqnmkmlke knkwnkrqev 301 idyiaqetgd irsaittlqf watssgslpi strestisyf haigkvihgs hstnndnemi 361 nnlfensnnl lskedfklgi lenyntfnkg efsisdassi vdclsecdnm nglpesneyg 421 lrevrktfrn iskqghnhgt vyfprewkvr klqnsfkvqa edwlnvslyk ynavhsfrni 481 tlefgyyapl irkcqsykkk yilyylknlp sgssgpkqtm dkfsdimkve ngidvvdrig 541 gpiealsved glaplmdnds nncdhledqk kerdrrlrml idqyernvmm anddledeet 601 sfnddpivds dsdnsnnign etfgrsdede slceilsqrq prkapvises lsdsdleil // LOCUS NP_011101 244 aa linear PLN 30-JUN-2025 DEFINITION monothiol glutaredoxin GRX4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011101 VERSION NP_011101.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179064.3 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07836. On Jul 30, 2012 this sequence version replaced NP_011101.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..244 /product="monothiol glutaredoxin GRX4" /calculated_mol_wt="27362" Region 8..106 /region_name="TRX_PICOT" /note="TRX domain, PICOT (for PKC-interacting cousin of TRX) subfamily; PICOT is a protein that interacts with protein kinase C (PKC) theta, a calcium independent PKC isoform selectively expressed in skeletal muscle and T lymphocytes. PICOT contains an...; cd02984" /db_xref="CDD:239282" Region 149..233 /region_name="GRX_PICOT_like" /note="Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; cd03028" /db_xref="CDD:239326" Site order(163,171..173,211..212) /site_type="other" /note="putative GSH binding site [chemical binding]" /db_xref="CDD:239326" Site order(171,174) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239326" CDS 1..244 /gene="GRX4" /locus_tag="YER174C" /coded_by="NM_001179064.3:1..735" /experiment="EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:32098918]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14519092]" /experiment="EXISTENCE:genetic interaction:GO:0006879 intracellular iron ion homeostasis [PMID:17074835]" /experiment="EXISTENCE:mutant phenotype:GO:0015036 disulfide oxidoreductase activity [PMID:10567543|PMID:27085841]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:20889785]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10567543|PMID:17074835]" /experiment="EXISTENCE:mutant phenotype:GO:2000678 negative regulation of transcription regulatory region DNA binding [PMID:23045394]" /experiment="EXISTENCE:physical interaction:GO:0006879 intracellular iron ion homeostasis [PMID:17074835]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:23045394]" /note="Glutathione-dependent oxidoreductase and glutathione S-transferase; hydroperoxide/superoxide-radical responsive monothiol glutaredoxin subfamily member with Grx3p and Grx5p; protects cells from oxidative damage with GRX3 and GRX5; with Grx3p, promotes dissociation of Aft1p from iron regulon gene promoters and subsequent nuclear export in iron-replete conditions, regulating iron homeostasis; involved with Grx3p in Sir2p deglutathionylation, restoring deacetylase activity after disulfide stress" /db_xref="GeneID:856921" /db_xref="SGD:S000000976" ORIGIN 1 mtvveiksqd qftqltttna anklivlyfk aqwadpcktm sqvleavsek vrqedvrfls 61 idadehpeis dlfeiaavpy fvfiqngtiv keisaadpke fvksleilsn asaslannak 121 gpkstsdees sgssddeede teeeinarlv klvqaapvml fmkgspsepk cgfsrqlvgi 181 lrehqirfgf fdilrdenvr qslkkfsdwp tfpqlyinge fqggldiike sieedpeyfq 241 halq // LOCUS NP_011102 299 aa linear PLN 30-JUN-2025 DEFINITION trans-aconitate 3-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011102 VERSION NP_011102.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179065.3 REFERENCE 1 (residues 1 to 299) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 299) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 299) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 299) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07837. On Jul 30, 2012 this sequence version replaced NP_011102.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..299 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..299 /product="trans-aconitate 3-methyltransferase" /EC_number="2.1.1.145" /calculated_mol_wt="34637" Region 25..>147 /region_name="SmtA" /note="SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]; COG0500" /db_xref="CDD:440266" CDS 1..299 /gene="TMT1" /locus_tag="YER175C" /gene_synonym="TAM1" /coded_by="NM_001179065.3:1..900" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11695919]" /experiment="EXISTENCE:direct assay:GO:0034198 cellular response to amino acid starvation [PMID:18092814]" /experiment="EXISTENCE:direct assay:GO:0046547 trans-aconitate 3-methyltransferase activity [PMID:11695919]" /note="Trans-aconitate methyltransferase; cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle" /db_xref="GeneID:856922" /db_xref="SGD:S000000977" ORIGIN 1 mstfsasdfn serysssrps ypsdfykmid eyhdgerkll vdvgcgpgta tlqmaqelkp 61 feqiigsdls atmiktaevi kegspdtykn vsfkisssdd fkflgadsvd kqkidmitav 121 ecahwfdfek fqrsayanlr kdgtiaiwgy adpifpdype fddlmievpy gkqglgpywe 181 qpgrsrlrnm lkdshldpel fhdiqvsyfc aedvrdkvkl hqhtkkplli rkqvtlvefa 241 dyvrtwsayh qwkqdpknkd kedvadwfik eslrrrpels tntkievvwn tfyklgkrv // LOCUS NP_878069 54 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER175W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878069 VERSION NP_878069.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184589.1 REFERENCE 1 (residues 1 to 54) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 54) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 54) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 54) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07838. Method: conceptual translation. FEATURES Location/Qualifiers source 1..54 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..54 /product="uncharacterized protein" /calculated_mol_wt="6336" CDS 1..54 /locus_tag="YER175W-A" /coded_by="NM_001184589.1:1..165" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466537" /db_xref="SGD:S000028625" ORIGIN 1 mrlhktficf sqnkrgcrni lqensrmife nkilimilrq giffnisvst kisf // LOCUS NP_011103 1121 aa linear PLN 30-JUN-2025 DEFINITION RNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011103 VERSION NP_011103.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179066.1 REFERENCE 1 (residues 1 to 1121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1121) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07839. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1121 /product="RNA helicase" /EC_number="3.6.4.13" /calculated_mol_wt="126840" Region 612..1114 /region_name="TIGR00376" /note="DNA helicase, putative" /db_xref="CDD:273041" Region 860..1092 /region_name="AAA_12" /note="AAA domain; pfam13087" /db_xref="CDD:463780" CDS 1..1121 /gene="ECM32" /locus_tag="YER176W" /gene_synonym="HEL1; MTT1" /coded_by="NM_001179066.1:1..3366" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:9434351]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640|PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0006449 regulation of translational termination [PMID:10836794]" /note="DNA dependent ATPase/DNA helicase; helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes" /db_xref="GeneID:856923" /db_xref="SGD:S000000978" ORIGIN 1 mdfqcrtcsq aydaeqmmkh lsstrhktvf dtsndedicc eecqdknihq lqiirfgged 61 mvllcnscfr keyseterps tsyslqngsi lkfwekyvkv recccdecge esnlnanrng 121 evlcdkclpk snrakdfvse ksgrflyiyl glnetqnstr kprkkggrrv grgkkgrkga 181 kikkekketf eakisriaye vkkenstiqs ssssnlrnfk gfkavesdpv vaakvskset 241 srsnpgpsnr nkgkgnkanh kknsgngigk ekerktnirn nvrnsqpipe drkntnshvt 301 tnsggkgkne svdkhqlpqp kalngngsgs tnttglkkgk kdhagqktkg ndktgnknpr 361 eaklnsagrk nalgkksnnq pnkgtsrwti gsdtessrep sispnentts itksrnrnkk 421 askptlneks ktttmpkkle tknqeknngk tkdgkliyee gepltryntf kstlsypdln 481 tylndysfal fleqklenef vqnfnilwpr nekdtafiin veknnnsele kllpanllal 541 grpafnerqp fffctqdeqk vwyifikels iqrgkyvllv elfswnnlsl ptkngssqfk 601 llptsaqtsr ilfamtritn pkfidlllgq kpikeiyfdn rlkfssdkln rsqktavehv 661 lnnsitilqg ppgtgktsti eeiiiqvier fhafpilcva asniaidnia ekimenrpqi 721 kilrilskkk eqqysddhpl geiclhnivy knlspdmqvv anktrrgemi sksedtkfyk 781 eknrvtnkvv sqsqiifttn iaaggrelkv ikecpvvimd eatqsseast lvplslpgir 841 nfvfvgdekq lssfsnipql etslfervls ngtyknplml dtqyrmhpki sefpikkiyn 901 gelkdgvtde qkawpgvqhp lffyqcdlgp esrvrstqrd ivgftyenkh ecveivkiiq 961 ilmldkkvpl eeigvitpys aqrdllsdil tknvvinpkq ismqqeydei elfnaagsqg 1021 tagslqnnvi niinglhvat vdsfqgheks fiifscvrnn tenkigflrd krrlnvaltr 1081 akhglivvgn knvlrkgdpl wkdyitylee qeviftdlta y // LOCUS NP_011104 267 aa linear PLN 30-JUN-2025 DEFINITION 14-3-3 family protein BMH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011104 VERSION NP_011104.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179067.3 REFERENCE 1 (residues 1 to 267) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 267) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 267) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 267) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07840. On Jul 30, 2012 this sequence version replaced NP_011104.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..267 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..267 /product="14-3-3 family protein BMH1" /calculated_mol_wt="29960" Region 1..267 /region_name="BMH1" /note="14-3-3 family protein [Signal transduction mechanisms]; COG5040" /db_xref="CDD:227373" Site order(11,14..15,17..18,20,23,60,63,67,83,87,90..91,94) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:206755" Site order(51,58,125,132..133,174,177..178,181,184..185,222,225, 228..229) /site_type="other" /note="peptide binding site [polypeptide binding]" /db_xref="CDD:206755" CDS 1..267 /gene="BMH1" /locus_tag="YER177W" /gene_synonym="APR6" /coded_by="NM_001179067.3:1..804" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:12167636]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25409301|PMID:12167636|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:25409301]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:24142105]" /experiment="EXISTENCE:genetic interaction:GO:0001402 signal transduction involved in filamentous growth [PMID:9215628]" /experiment="EXISTENCE:genetic interaction:GO:0006031 chitin biosynthetic process [PMID:17559233]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:9215628]" /experiment="EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:9215628]" /experiment="EXISTENCE:genetic interaction:GO:0030437 ascospore formation [PMID:9215628]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:24850890]" /experiment="EXISTENCE:genetic interaction:GO:0070873 regulation of glycogen metabolic process [PMID:9215628]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:14704161]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:24142105]" /experiment="EXISTENCE:mutant phenotype:GO:0043066 negative regulation of apoptotic process [PMID:22785534]" /experiment="EXISTENCE:mutant phenotype:GO:0050815 phosphoserine residue binding [PMID:9822578]" /experiment="EXISTENCE:mutant phenotype:GO:0070842 aggresome assembly [PMID:23843611]" /experiment="EXISTENCE:physical interaction:GO:0000278 mitotic cell cycle [PMID:17030612]" /experiment="EXISTENCE:physical interaction:GO:0031397 negative regulation of protein ubiquitination [PMID:17030612]" /note="14-3-3 protein, major isoform; involved in post-transcriptional control of the proteome; binds to both proteins and to DNA, including replication origins; regulates exocytosis, vesicle transport, Ras/MAPK and rapamycin-sensitive signaling, aggresome formation, the spindle position checkpoint and meiotic commitment; protein abundance and relative distribution to the nucleus increase upon DNA replication stress; antiapoptotic gene; similar to several human 14-3-3 proteins" /db_xref="GeneID:856924" /db_xref="SGD:S000000979" ORIGIN 1 mstsredsvy laklaeqaer yeemvenmkt vassgqelsv eernllsvay knvigarras 61 wrivssieqk eeskeksehq velicsyrsk ieteltkisd dilsvldshl ipsattgesk 121 vfyykmkgdy hrylaefssg darekatnas leayktasei attelppthp irlglalnfs 181 vfyyeiqnsp dkachlakqa fddaiaeldt lseesykdst limqllrdnl tlwtsdmses 241 gqaedqqqqq qhqqqqppaa aegeapk // LOCUS NP_011105 420 aa linear PLN 30-JUN-2025 DEFINITION pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_011105 VERSION NP_011105.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179068.3 REFERENCE 1 (residues 1 to 420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 420) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07841. On Jul 30, 2012 this sequence version replaced NP_011105.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..420 /product="pyruvate dehydrogenase (acetyl-transferring) subunit E1 alpha" /EC_number="1.2.4.1" /calculated_mol_wt="46212" Region 50..394 /region_name="TPP_enzymes" /note="Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; cl01629" /db_xref="CDD:470272" Site order(108,160,185..186,217,219..222,225,229,233,248..251, 265,268,316,320) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:238958" Site order(138..139,185,187,215..218,245,247,312) /site_type="other" /note="TPP-binding site [chemical binding]" /db_xref="CDD:238958" Site order(180,182,184,189,192..193,196..197,199..200,203, 222..223,229..230,233) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:238958" Site order(307..313,315..325,334..336) /site_type="phosphorylation" /note="phosphorylation loop region [posttranslational modification]" /db_xref="CDD:238958" CDS 1..420 /gene="PDA1" /locus_tag="YER178W" /coded_by="NM_001179068.3:1..1263" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:7589446|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006086 pyruvate decarboxylation to acetyl-CoA [PMID:7947791]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:direct assay:GO:0045254 pyruvate dehydrogenase complex [PMID:2007123]" /experiment="EXISTENCE:mutant phenotype:GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity [PMID:11589696]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:24603354]" /note="E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes" /db_xref="GeneID:856925" /db_xref="SGD:S000000980" ORIGIN 1 mlaasfkrqp sqlvrglgav lrtptrighv rtmatlkttd kkapediegs dtvqielpes 61 sfesymlepp dlsyetskat llqmykdmvi irrmemacda lykakkirgf chlsvgqeai 121 avgienaitk ldsiitsyrc hgftfmrgas vkavlaelmg rragvsygkg gsmhlyapgf 181 yggngivgaq vplgaglafa hqyknedacs ftlygdgasn qgqvfesfnm aklwnlpvvf 241 ccennkygmg taasrssamt eyfkrgqyip glkvngmdil avyqaskfak dwclsgkgpl 301 vleyetyryg ghsmsdpgtt yrtrdeiqhm rskndpiagl kmhlidlgia teaevkaydk 361 sarkyvdeqv eladaapppe aklsilfedv yvkgtetptl rgripedtwd fkkqgfasrd // LOCUS NP_011106 334 aa linear PLN 30-JUN-2025 DEFINITION recombinase DMC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011106 VERSION NP_011106.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179069.1 REFERENCE 1 (residues 1 to 334) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 334) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 334) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 334) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07842. Method: conceptual translation. FEATURES Location/Qualifiers source 1..334 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..334 /product="recombinase DMC1" /calculated_mol_wt="36482" Region 19..332 /region_name="recomb_DMC1" /note="meiotic recombinase Dmc1; TIGR02238" /db_xref="CDD:131292" CDS 1..334 /gene="DMC1" /locus_tag="YER179W" /gene_synonym="ISC2" /coded_by="NM_001179069.1:1..1005" /experiment="EXISTENCE:direct assay:GO:0000150 DNA strand exchange activity [PMID:23769192]" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:1581960]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:11551925]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:11551925]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141|PMID:7528104]" /experiment="EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:30301803]" /experiment="EXISTENCE:genetic interaction:GO:0007130 synaptonemal complex assembly [PMID:24367271]" /experiment="EXISTENCE:mutant phenotype:GO:0000709 meiotic joint molecule formation [PMID:9323140|PMID:22955832]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:16581767|PMID:1581960]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:1581960]" /note="Meiosis-specific recombinase required for double-strand break repair; also required for pairing between homologous chromosomes and for the normal morphogenesis of synaptonemal complex; binds ssDNA and dsDNA, forms helical filaments; potent inhibitor of the ATPase activity of Srs2p helicase, blocking its ssDNA translocating motor activity and inhibiting its antirecombinase activity; stimulated by Rdh54p; homolog of Rad51p and the bacterial RecA protein" /db_xref="GeneID:856926" /db_xref="SGD:S000000981" ORIGIN 1 msvtgteids dtaknilsvd elqnyginas dlqklksggi ytvntvlstt rrhlckikgl 61 sevkvekike aagkiiqvgf ipatvqldir qrvyslstgs kqldsilggg imtmsitevf 121 gefrcgktqm shtlcvttql premgggegk vayidtegtf rperikqiae gyeldpescl 181 anvsyaraln sehqmelveq lgeelssgdy rlivvdsima nfrvdycgrg elserqqkln 241 qhlfklnrla eefnvavflt nqvqsdpgas alfasadgrk pigghvlaha satrillrkg 301 rgdervaklq dspdmpekec vyvigekgit dssd // LOCUS NP_011107 267 aa linear PLN 30-JUN-2025 DEFINITION Isc10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011107 VERSION NP_011107.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179070.1 REFERENCE 1 (residues 1 to 267) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 267) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 267) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 267) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07843. Method: conceptual translation. FEATURES Location/Qualifiers source 1..267 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..267 /product="Isc10p" /calculated_mol_wt="31524" CDS 1..267 /gene="ISC10" /locus_tag="YER180C" /coded_by="NM_001179070.1:1..804" /experiment="EXISTENCE:direct assay:GO:0004860 protein kinase inhibitor activity [PMID:32423992]" /experiment="EXISTENCE:direct assay:GO:0051019 mitogen-activated protein kinase binding [PMID:32423992]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:8455558]" /note="Meiosis-specific MAPK inhibitor; binds Smk1p during meiosis I; links APC/C-Ama1 to Smk1p activation; required for sporulation; transcript is induced 7.5 hr after induction of meiosis; Isc10p is ubiquitylated and degraded in an Ama1p-dependent manner upon completion of meiosis II" /db_xref="GeneID:856927" /db_xref="SGD:S000000982" ORIGIN 1 mdvderlhqd enqthpfsqk ksssflikek aatkskdleh irlrdlnfnh rkklddkkla 61 kqipvkanfk kpneiearan lnsneltdin ldyipdspsi ekisgpedsi vvtprniihl 121 qsdsdiilee cehnydcspf yrlfnyenri epddyeaiin aiitdeiagt ypvfereley 181 qelkslvrkr dyimyyflsr dyrgffqlke ertlfyryps iaytsplryl dngseteqft 241 gdddeelqsf dfentssvrt ldsniwr // LOCUS NP_796378 85 aa linear PLN 30-JUN-2025 DEFINITION Slo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_796378 VERSION NP_796378.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184517.3 REFERENCE 1 (residues 1 to 85) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 85) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 85) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 85) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07844. On Jul 30, 2012 this sequence version replaced NP_796378.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..85 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..85 /product="Slo1p" /calculated_mol_wt="9604" CDS 1..85 /gene="SLO1" /locus_tag="YER180C-A" /coded_by="NM_001184517.3:1..258" /experiment="EXISTENCE:physical interaction:GO:0006886 intracellular protein transport [PMID:12620189]" /note="Protein interacting with Arl3p; Arl3p is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO" /db_xref="GeneID:856928" /db_xref="SGD:S000028437" ORIGIN 1 msaenistgs ptgkqpssev nlgereagtk nermmrqtkl lkdtldllwn ktleqqevce 61 qlkqendyle dyignlmrss nvlek // LOCUS NP_011109 244 aa linear PLN 30-JUN-2025 DEFINITION Fmp10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011109 VERSION NP_011109.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179072.3 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07845. On Jul 30, 2012 this sequence version replaced NP_011109.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..244 /product="Fmp10p" /calculated_mol_wt="27567" Region <142..233 /region_name="PaaI" /note="Acyl-CoA thioesterase PaaI, contains HGG motif [Secondary metabolites biosynthesis, transport and catabolism]; COG2050" /db_xref="CDD:441653" CDS 1..244 /gene="FMP10" /locus_tag="YER182W" /coded_by="NM_001179072.3:1..735" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:14562095|PMID:16823961|P MID:24390141]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:856931" /db_xref="SGD:S000000984" ORIGIN 1 mfkriaiaqi rtytngvvfk taskpkrrwi pwtifggsfl ggwyltqhmt ftdllaywry 61 dalpknadev vkyhadlnrr lnglpivkql enagfvqvia neeenllvsr alntpggvai 121 pprvyynpsr retvglyhlg mkltgypfli hggilatvie dlmkeairle kgtkninqet 181 knlsisykfp tlanqfvvvr ttdlqqygnk tklkaelmdq sgnrtlvkan atfsseqgnp 241 keek // LOCUS NP_011110 211 aa linear PLN 30-JUN-2025 DEFINITION 5-formyltetrahydrofolate cyclo-ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011110 VERSION NP_011110.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179073.1 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07846. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..211 /product="5-formyltetrahydrofolate cyclo-ligase" /EC_number="6.3.3.2" /calculated_mol_wt="23928" Region 4..203 /region_name="5-FTHF_cyc-lig" /note="5-formyltetrahydrofolate cyclo-ligase family; pfam01812" /db_xref="CDD:396398" CDS 1..211 /gene="FAU1" /locus_tag="YER183C" /coded_by="NM_001179073.1:1..636" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0009396 folic acid-containing compound biosynthetic process [PMID:11923304]" /experiment="EXISTENCE:direct assay:GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity [PMID:11923304]" /note="5,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis" /db_xref="GeneID:856932" /db_xref="SGD:S000000985" ORIGIN 1 matkqllrrq ikrvinaldy diiaaeshti sqavrslias ansrrvacym smdkgevttg 61 eiiknlfqdg qevflprcth tseskhfklr edhhphlifh rmsslkmvrd lkpqgpyqlk 121 epephieesd ildvvlvpgv afdiktgarm ghgagyyddf fqrykilheg qkpllvglcl 181 meqvaspipl ekhdysmdci vcgdgsihwf q // LOCUS NP_011111 794 aa linear PLN 30-JUN-2025 DEFINITION Tog1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011111 VERSION NP_011111.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179074.1 REFERENCE 1 (residues 1 to 794) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 794) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 794) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 794) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 794) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 794) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 794) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 794) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 794) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07847. Method: conceptual translation. FEATURES Location/Qualifiers source 1..794 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..794 /product="Tog1p" /calculated_mol_wt="90946" Site order(13,17,22..25,27,39) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Region 16..53 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(18,21,28,34,37,44) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 236..485 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..794 /gene="TOG1" /locus_tag="YER184C" /coded_by="NM_001179074.1:1..2385" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:24998441|PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:24998441]" /note="Transcriptional activator of oleate genes; regulates genes involved in fatty acid utilization; zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source" /db_xref="GeneID:856933" /db_xref="SGD:S000000986" ORIGIN 1 maakrglakq ksrvtkacdr chrkkikcns kkpcfgcigs qskctyrnqf repieaffny 61 tgslsndldn akcsiaklka qlppsapasl qkglanicte lekiqpqlyl nldskeissy 121 gglksietei igkqskslnr fsnafesnta qnvsmyfgvy spllyfastg iswitkklis 181 csndretret iylflkflda ssashagpkv tsispleyys klnglscgnd vliqhimsni 241 sneikgntni nqtikfnkpt dwfmygvqlm eqhhkaldrk sskkllplky fleqdelifc 301 lcleyfersl fstmydltil kglvslmkhr ywiddpfvlg riistmsrrs ldaglnrwey 361 yigqdedtae eyrklwwdcy wwdrwyslvt gkqpliphem tsclfpkdvv glgvddsmdc 421 ftlinlveld pskfdicisf gyilltkiit avfsgllynr hftdyrlfat pnakdlngta 481 rqlmvefski ckifqciqdk lipflkqyse nsnvfelyth fgfakvccfq gmeslilriq 541 nllqererie ldscvkdirl qtfeasvdil tdvlkhedtf yifrcswfiy ailmnitlnf 601 ietprrnsic ylslmcrmia syndlfvssg nvnfkgnnaf skklengtav sfiltriccq 661 mytrsqkmak eslfcelkky gqacsdagqa aldieciwyr niigehkess frkeilsild 721 remgdlvnnr vigvqgknqe gacyeklsps stsvsvgmdf cslenfvtae slpdllnlfw 781 edtefgitke nlge // LOCUS NP_011112 303 aa linear PLN 30-JUN-2025 DEFINITION Pug1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011112 VERSION NP_011112.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179075.3 REFERENCE 1 (residues 1 to 303) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 303) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 303) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 303) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07848. On Jul 30, 2012 this sequence version replaced NP_011112.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..303 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..303 /product="Pug1p" /calculated_mol_wt="33602" Region 84..292 /region_name="RTA1" /note="RTA1 like protein; pfam04479" /db_xref="CDD:461325" CDS 1..303 /gene="PUG1" /locus_tag="YER185W" /coded_by="NM_001179075.3:1..912" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18326586]" /experiment="EXISTENCE:mutant phenotype:GO:0035351 heme transmembrane transport [PMID:18326586]" /note="Plasma membrane protein involved in protoprophyrin and heme transport; roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins" /db_xref="GeneID:856934" /db_xref="SGD:S000000987" ORIGIN 1 msttdsgfvl yhytpskaaa ivfvvlfiim tvifavqtly aarksskalk nnpfessddk 61 vdsledaeyk qlkitptvfa fipfftgcim eavgyigral sssnperttp yiiqsvlllv 121 apaliaatiy mifgrllhvm rcqslilisa rfgttffvvg dvfsfflqaa ggglmskags 181 tktgsglita glfvqviffg ffiineirft vnvkrrclfy edisrkwifv natlllssml 241 illrsivriv efiqgfngyi isheyfiyvf davpmllvii afsvgsffgn vfdvikecqt 301 lsn // LOCUS NP_011113 306 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER186C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011113 VERSION NP_011113.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179076.3 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07849. On Jul 30, 2012 this sequence version replaced NP_011113.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..306 /product="uncharacterized protein" /calculated_mol_wt="35781" CDS 1..306 /locus_tag="YER186C" /coded_by="NM_001179076.3:1..921" /note="hypothetical protein" /db_xref="GeneID:856935" /db_xref="SGD:S000000988" ORIGIN 1 mlwhpdgyep rvkaieeeiy anedrkdvpd kfkfdtvtkt gmvklrvfkd dlifksqrsi 61 nlfasrkhpf ksftadgegl plfafrtkkp ffvrrdyvgf lfyqyeilkn gdfpeesdye 121 vkgecdgftl fkvlfctvkv kktsyyrnke rishilelnf gkkedfrilt lvrcseirsv 181 yvvedkkvim kwvftseskf nlnsslfiik aaigclpevg dsiedipkfd wdscptigcm 241 crtkealfqp esrkdmhicp qlflgetgpp hynessvpwl tkmnicisvl infleytdfm 301 swmqdn // LOCUS NP_011114 141 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER187W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011114 VERSION NP_011114.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179077.1 REFERENCE 1 (residues 1 to 141) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 141) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 141) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 141) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07850. Method: conceptual translation. FEATURES Location/Qualifiers source 1..141 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..141 /product="uncharacterized protein" /calculated_mol_wt="15264" Region 2..135 /region_name="DUF5341" /note="Family of unknown function (DUF5341); pfam17276" /db_xref="CDD:407389" CDS 1..141 /locus_tag="YER187W" /coded_by="NM_001179077.1:1..426" /note="hypothetical protein; induced in respiratory-deficient cells" /db_xref="GeneID:856937" /db_xref="SGD:S000000989" ORIGIN 1 mlidqivaav pgvpdisgna salslqrrsq efatswismt ysqsygdlaq nwqndeggag 61 nfdsyaeekl qnffsgnrdw kycfaaedtk ngepldyddi pgdgagtgsa fkseiyfnty 121 ggidnycnde higaqntgdg r // LOCUS NP_878070 99 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER188C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878070 VERSION NP_878070.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184633.1 REFERENCE 1 (residues 1 to 99) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 99) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 99) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 99) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07851. Method: conceptual translation. FEATURES Location/Qualifiers source 1..99 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..99 /product="uncharacterized protein" /calculated_mol_wt="11280" Region 16..99 /region_name="DUF468" /note="Protein of unknown function (DUF468); pfam04318" /db_xref="CDD:367903" CDS 1..99 /locus_tag="YER188C-A" /coded_by="NM_001184633.1:1..300" /note="hypothetical protein" /db_xref="GeneID:1466538" /db_xref="SGD:S000028764" ORIGIN 1 mahlslnqyk cthiimhgtc lsglypvpft hkahdyphfn iyisfggpky citalntyvi 61 plfhhllstq fiytyvnitk ksplkspkhk nilsfndnt // LOCUS NP_011116 122 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER189W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011116 VERSION NP_011116.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179079.3 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07852. On Jul 30, 2012 this sequence version replaced NP_011116.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..122 /product="uncharacterized protein" /calculated_mol_wt="13877" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" CDS 1..122 /locus_tag="YER189W" /coded_by="NM_001179079.3:1..369" /note="hypothetical protein" /db_xref="GeneID:856939" /db_xref="SGD:S000000991" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekivisvmv gknvqkfltf vedepdfqgg pipsnkprdg lhvvssayfe 121 iq // LOCUS NP_011117 1681 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase protein 1 copy 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011117 VERSION NP_011117.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179080.3 REFERENCE 1 (residues 1 to 1681) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1681) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 1681) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1681) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1681) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1681) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1681) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1681) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1681) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07853. On Jul 30, 2012 this sequence version replaced NP_011117.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1681 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..1681 /product="Y' element ATP-dependent helicase protein 1 copy 2" /EC_number="3.6.4.12" /calculated_mol_wt="190373" Region 676..848 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" Region 923..1018 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1681 /gene="YRF1-2" /locus_tag="YER190W" /gene_synonym="YRF1" /coded_by="NM_001179080.3:1..5046" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9837911]" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:9837911]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]" /note="Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation" /db_xref="GeneID:856940" /db_xref="SGD:S000000992" ORIGIN 1 mvytlfqvht lkfnrkdydt lslfylnrgy ynelsfrvle rchekasarp ndsstmrtft 61 dfvsgapivr slqkstirky gynlapymfl llhvdelsif sayqaslpge kkvdterlkr 121 dlcprkptei kyfsqicndm mnkkdrlgdi lhiilracal nfgagprgga gdeedrsitn 181 eepiipsvde hglkvcklrs pntprrlrkt ldavkallvs scactardld ifddnngvam 241 wkwikilyhe vaqetalkds yritlvpssd gvsvcgklfn reyvrgfyfa ckaqfdnlwe 301 elndcfympt vvdiaslilr nrevlfrepk rgideylend sflqmipvky reivlpklrr 361 dtnkmtaalk nkvtvaidel tvplmwmihf avgypyrype lqllafagpq rnvyvddttr 421 riqlytdynk ngsseprlkt ldgltsdyvf yfvtvlrqmq icalgnsyda fnhdpwmdvv 481 gfedpdqvtn rdisrivlys ymflntakgc lveyatfrqy mrelpknapq klnfremrqg 541 lialgrhcvg srfetdlyes atselmanhs vqtgrniygv dsfsltsvsg ttatllqera 601 serwiqwlgl esdyhcsfss trnaedvvag eaassdhhqk isrvtrkrpr epkstndilv 661 agqklfgssf efrdlhqlrl cheiymadtp svavqappgy gktelfhlpl ialaskgdvk 721 yvsflfvpyt vllancmirl srcgclnvap vrnfieegcd gvtdlyvgiy ddlastnftd 781 riaawenive ctfrtnnvkl gylivdefhn fetevyrqsq fggitnldfd afekaiflsg 841 tapeavadaa lqrigltgla kksmdinelk rsedlsrgls syptrmfnli keksevplgh 901 vhkiwkkves qpeealklll alfeiepesk aivvasttne veelacswrk yfrvvwihgk 961 lgaaekvsrt kefvtdgsmr vligtklvte gidikqlmmv imldnrlnii eliqgvgrlr 1021 dgglcyllsr knswaarnrk gelppikegc iteqvrefyg leskkgkkgq hvgccgsrtd 1081 lsadtvelie rmdrlaekqa tasmsivalp ssfqesnssd rcrkycssde dsdtcihgsa 1141 nastnattns stnatttast nvrtsattta sinvrtsatt testnsstna tttastnvrt 1201 satttasinv rtsatttest nsntsattte stdsntsatt testdsntsa tttastnsst 1261 natttastns stnatttest nasakedank dgnaednrfh pvtdinkesy krkgsqmvll 1321 erkklkaqfp ntsenmnvlq flgfrsdeik hlflygidvy fcpegvftqy glckgcqkmf 1381 elcvcwagqk vsyrrmawea lavermlrnd eeykeyledi epyhgdpvgy lkyfsvkrge 1441 iysqiqrnya wylaitrrre tisvldstrg kqgsqvfrms grqikelyyk vwsnlreskt 1501 evlqyflnwd ekkcreewea kddtvfveal ekvgvfqrlr smtsaglqgp qyvklqfsrh 1561 hrqlrsryel slgmhlrdql algvtpskvp hwtaflsmli glfcnktfrq kleylleqis 1621 evwllphwld lanvevlaad ntrvplymlm vavhkeldsd dvpdgrfdil lcrdssrevg 1681 e // LOCUS NP_001073292 160 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER190C-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_001073292 VERSION NP_001073292.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184590.1 REFERENCE 1 (residues 1 to 160) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 160) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 160) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07854. Method: conceptual translation. FEATURES Location/Qualifiers source 1..160 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..160 /product="uncharacterized protein" /calculated_mol_wt="18471" CDS 1..160 /locus_tag="YER190C-B" /coded_by="NM_001184590.1:1..483" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:4594642" /db_xref="SGD:S000028627" ORIGIN 1 mmpaklqldv lrtlqssarh gtqtlknsnf lerfhkdriv fclpffpalf fvpvqkvlqh 61 lclrftqvap yfiiqlfdlp srhaenlapl lascriqytn cfssssngqv psiislylrv 121 dlspfyakif qisyrvpmiw ldvfqvffvf lvisqhslhs // LOCUS NP_001335770 107 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER181C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335770 VERSION NP_001335770.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348828.1 REFERENCE 1 (residues 1 to 107) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 107) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 107) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 107) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80290. Method: conceptual translation. FEATURES Location/Qualifiers source 1..107 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..107 /product="uncharacterized protein" /calculated_mol_wt="12327" CDS 1..107 /locus_tag="YER181C" /coded_by="NM_001348828.1:1..324" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="Mitochondrial hypothetical protein; conserved among S. cerevisiae strains; extensively overlaps a Ty1 LTR; YER181C is not an essential gene" /db_xref="GeneID:856930" /db_xref="SGD:S000000983" ORIGIN 1 mlillrlsev cvnfviiigi pllieasilc iqnilelllk gigilkfnry lhtiilrlff 61 lsfymlhfpi tlsilafqlp lnlltlsqas fhlprshmil yqqqecy // LOCUS NP_001335771 239 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YER188W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335771 VERSION NP_001335771.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348829.1 REFERENCE 1 (residues 1 to 239) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 239) AUTHORS Dietrich,F.S., Mulligan,J., Hennessy,K., Yelton,M.A., Allen,E., Araujo,R., Aviles,E., Berno,A., Brennan,T., Carpenter,J., Chen,E., Cherry,J.M., Chung,E., Duncan,M., Guzman,E., Hartzell,G., Hunicke-Smith,S., Hyman,R.W., Kayser,A., Komp,C., Lashkari,D., Lew,H., Lin,D., Mosedale,D., Davis,R.W. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome V JOURNAL Nature 387 (6632 SUPPL), 78-81 (1997) PUBMED 9169868 REFERENCE 3 (residues 1 to 239) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 239) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (29-JUL-2014) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80291. Method: conceptual translation. FEATURES Location/Qualifiers source 1..239 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="V" Protein 1..239 /product="uncharacterized protein" /calculated_mol_wt="27181" CDS 1..239 /locus_tag="YER188W" /coded_by="NM_001348829.1:1..720" /note="hypothetical protein; conserved across S. cerevisiae strains; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p" /db_xref="GeneID:856938" /db_xref="SGD:S000000990" ORIGIN 1 mmptylgklt wsyffttlgl acaynvteqm efdqfksdyl aclapehrni vvdlasngfi 61 tispmanati dfedvtsdyf nctdvntnvq vtiasfyney gfgpddngyy hameepsefe 121 rhdmdvrlyr pyypgefvmg rrsdalgvtg fdqkdcageg fydeqtaats cqnigstqya 181 ksvrsynygc cggavwiriw phhncskghd hhfkirpgqm lcwnvnpysw mqpesgwnp // LOCUS NP_116587 160 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFL068W [Saccharomyces cerevisiae S288C]. ACCESSION NP_116587 VERSION NP_116587.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179899.1 REFERENCE 1 (residues 1 to 160) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 160) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 160) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12373. Method: conceptual translation. FEATURES Location/Qualifiers source 1..160 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..160 /product="uncharacterized protein" /calculated_mol_wt="18462" CDS 1..160 /locus_tag="YFL068W" /coded_by="NM_001179899.1:1..483" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol" /db_xref="GeneID:850476" /db_xref="SGD:S000001826" ORIGIN 1 mmpaklqldv lrtlqssarh gtqtlknsnf lerfhkdriv fclpffpalf lvpvqkvlqh 61 lclrftqvap yfiiqlfdlp srhaenlapl lascriqytn cfssssngqv psiislylrv 121 dlspfyakkf qipyrvpmiw ldvfqvffvf lvisqhslhs // LOCUS NP_116588 175 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFL067W [Saccharomyces cerevisiae S288C]. ACCESSION NP_116588 VERSION NP_116588.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179900.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 175) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12374. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..175 /product="uncharacterized protein" /calculated_mol_wt="16342" Region <12..>147 /region_name="ser_rich_anae_1" /note="serine-rich protein; NF033849" /db_xref="CDD:468206" CDS 1..175 /locus_tag="YFL067W" /coded_by="NM_001179900.1:1..528" /note="hypothetical protein; down-regulated at low calcium levels; mCherry fusion protein localizes to the vacuole" /db_xref="GeneID:850477" /db_xref="SGD:S000001827" ORIGIN 1 mesiilsiai figvllgtsv gagsgssisp dvdagsgsrt spdvdagsgs risagvgtfs 61 gsstspdvda gsgsstspdv gagsgssisa gvgsrigtgi gsrigtgigt gigsristsi 121 gsrispdvgt ssgnristgv stgisttmna rvavlitaai lsapvtaial learr // LOCUS NP_116589 392 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116589 VERSION NP_116589.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179901.1 REFERENCE 1 (residues 1 to 392) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 392) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 392) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 392) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12375. Method: conceptual translation. FEATURES Location/Qualifiers source 1..392 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..392 /product="Y' element ATP-dependent helicase" /EC_number="3.6.4.12" /calculated_mol_wt="43698" Region 6..163 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" Region 238..333 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..392 /locus_tag="YFL066C" /coded_by="NM_001179901.1:1..1179" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /note="Helicase-like protein encoded within the telomeric Y' element; induced by treatment with 8-methoxypsoralen and UVA irradiation; SWAT-GFP and mCherry fusion proteins localize to the nucleus" /db_xref="GeneID:850478" /db_xref="SGD:S000001828" ORIGIN 1 madtpsvavq appgygktel fhlplialas kgdvkyvsfl fvpytvllan cmirlgrrgc 61 lnvapvrnfi eegydgvtdl yvgiyddlas tnftdriaaw enivectfrt nnvklgyliv 121 defhnfetev yrqsqfggit nldfdafeka iflsgtapea vadaalqrig ltglakksmd 181 inelkrsedl srglssyptr mfnlikekse vplghvhkiw kkvesqpeea lklllalfei 241 epeskaivva sttneveela cswrkyfrvv wihgklgaae kvsrtkefvt dgsmqvligt 301 klvtegidik qlmmvimldn rlniieliqg vgrlrdgglc yllsrknswa arnrkgelpp 361 ikegciteqv refygleskk gkkgqhvgcc vc // LOCUS NP_116590 102 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFL065C [Saccharomyces cerevisiae S288C]. ACCESSION NP_116590 VERSION NP_116590.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179902.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 102) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12376. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..102 /product="uncharacterized protein" /calculated_mol_wt="11654" CDS 1..102 /locus_tag="YFL065C" /coded_by="NM_001179902.1:1..309" /note="hypothetical protein; induced by treatment with 8-methoxypsoralen and UVA irradiation" /db_xref="GeneID:850479" /db_xref="SGD:S000001829" ORIGIN 1 mrtftdfvsg apivrslqks tirkygynla phmflllhvd elsifsayqa slpgekkvdt 61 erlkrdlcpr kpieikyfsq icndmmnkkd rlgdvlrvcc ps // LOCUS NP_116591 174 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFL064C [Saccharomyces cerevisiae S288C]. ACCESSION NP_116591 VERSION NP_116591.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179903.1 REFERENCE 1 (residues 1 to 174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 174) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12377. Method: conceptual translation. FEATURES Location/Qualifiers source 1..174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..174 /product="uncharacterized protein" /calculated_mol_wt="20296" Region <2..159 /region_name="PRK09822" /note="lipopolysaccharide core biosynthesis protein; Provisional; cl15945" /db_xref="CDD:276137" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" CDS 1..174 /locus_tag="YFL064C" /coded_by="NM_001179903.1:1..525" /note="hypothetical protein" /db_xref="GeneID:850480" /db_xref="SGD:S000001830" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamnrkrs fekivisvmv gknvqkfltf vedepdfqgg pipskylipk kinlmvytlf 121 qvhtlkfnrk dydtlslfyl nrgyynelsf pcpgtlsrns ecqaerqlyd ayfh // LOCUS NP_116593 379 aa linear PLN 30-JUN-2025 DEFINITION Cos4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116593 VERSION NP_116593.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179905.1 REFERENCE 1 (residues 1 to 379) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 379) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 379) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 379) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12378. Method: conceptual translation. FEATURES Location/Qualifiers source 1..379 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..379 /product="Cos4p" /calculated_mol_wt="45181" Region 76..167 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 262..351 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..379 /gene="COS4" /locus_tag="YFL062W" /coded_by="NM_001179905.1:1..1140" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:25942624]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /db_xref="GeneID:850482" /db_xref="SGD:S000001832" ORIGIN 1 mkenelknek svdvlsfkql esqkivlpqd lfrssftwfc yeiykslafr iwmllwlpls 61 vwwklsnnwi yplmvsllvl fwgpvfvlvi frlsrkrsls kqltqfckei tkstpssdph 121 dwevvaanln sylyenkawn iryfffnamg cqeafrttll epfslkkdea akvksfkdsv 181 pyieealgvy frevekqwkl fnsekswspv gledaklpke ayrfkltwfl krisnifmli 241 pflnflcciy vsrgmclllr tlylgwilfm lvqgfqnirv limsmehkmq flstiineqe 301 sgangwdeia rkmnrylfek kvwkneefff dgidcewffs hffyrvlsak ksmralslnv 361 elwpyikeaq lscseesla // LOCUS NP_116594 225 aa linear PLN 30-JUN-2025 DEFINITION cyanamide hydratase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116594 VERSION NP_116594.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179906.1 REFERENCE 1 (residues 1 to 225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 225) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12379. Method: conceptual translation. FEATURES Location/Qualifiers source 1..225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..225 /product="cyanamide hydratase" /EC_number="4.2.1.69" /calculated_mol_wt="25021" Region 2..224 /region_name="cyanamide_fam" /note="HD domain protein, cyanamide hydratase family; TIGR03401" /db_xref="CDD:188314" Site order(55,88..89,157) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238032" Site 89 /site_type="other" /note="Mg2+ binding site [ion binding]" /db_xref="CDD:238032" CDS 1..225 /gene="DDI3" /locus_tag="YFL061W" /gene_synonym="DDI2" /coded_by="NM_001179906.1:1..678" /experiment="EXISTENCE:direct assay:GO:0018820 cyanamide hydratase activity [PMID:25847245]" /experiment="EXISTENCE:mutant phenotype:GO:0018890 cyanamide metabolic process [PMID:25847245]" /note="Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI2 and Ddi2p" /db_xref="GeneID:850483" /db_xref="SGD:S000001833" ORIGIN 1 msqygfvrvp revekaipvv naprpravvp ppnsetarlv reyaakelta pvlnhslrvf 61 qysvaiirdq fpawdldqev lyvtcllhdi attdknmrat kmsfeyyggi lsrelvfnat 121 ggnqdyadav teaiirhqdl tgtgyittlg lilqiattld nvgsntdlih idtvsaineq 181 fprlhwlscf atvvdtensr kpwghtsslg ddfskkvicn tfgyn // LOCUS NP_116595 222 aa linear PLN 30-JUN-2025 DEFINITION putative pyridoxal 5'-phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116595 VERSION NP_116595.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179907.1 REFERENCE 1 (residues 1 to 222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 222) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12380. Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..222 /product="putative pyridoxal 5'-phosphate synthase" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /calculated_mol_wt="25001" Region 7..217 /region_name="SNO" /note="SNO glutamine amidotransferase family; pfam01174" /db_xref="CDD:334414" Site order(57..59,91,120,151..152,197,199) /site_type="active" /note="predicted active site [active]" /db_xref="CDD:153220" Site order(91,197,199) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:153220" CDS 1..222 /gene="SNO3" /locus_tag="YFL060C" /coded_by="NM_001179907.1:1..669" /experiment="EXISTENCE:direct assay:GO:0008614 pyridoxine metabolic process [PMID:9791124]" /note="hypothetical protein; nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin" /db_xref="GeneID:850484" /db_xref="SGD:S000001834" ORIGIN 1 mtvvigvlal qgafiehvrh vekcivenrd fyekklsvmt vkdknqlaqc daliipgges 61 tamsliaert gfyddlyafv hnpskvtwgt cagliyisqq lsneaklvkt lnllkvkvkr 121 nafgrqaqss tricdfsnfi phcndfpatf irapvieevl dpehvqvlyk ldgkdnggqe 181 livaakqknn ilatsfhpel aendirfhdw firefvlkny sk // LOCUS NP_116596 298 aa linear PLN 30-JUN-2025 DEFINITION pyridoxine biosynthesis protein SNZ3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116596 VERSION NP_116596.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179908.1 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 298) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12381. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..298 /product="pyridoxine biosynthesis protein SNZ3" /EC_number="4.3.3.6" /calculated_mol_wt="31888" Region 6..298 /region_name="TIGR00343" /note="pyridoxal 5'-phosphate synthase, synthase subunit Pdx1" /db_xref="CDD:129443" Site order(21,40,78,150..152,213,232) /site_type="active" /db_xref="CDD:240078" Site order(55,57,65,80,83..85,88,105..109,151..153,155,158..159, 162,215,218..219,260) /site_type="other" /note="multimer interface [polypeptide binding]" /db_xref="CDD:240078" CDS 1..298 /gene="SNZ3" /locus_tag="YFL059W" /coded_by="NM_001179908.1:1..897" /experiment="EXISTENCE:direct assay:GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity [PMID:30498136]" /experiment="EXISTENCE:genetic interaction:GO:0008615 pyridoxine biosynthetic process [PMID:30498136]" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:30498136]" /note="Pyridoxal-5'-phosphate synthase; involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamine in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO3; paralog of SNZ1 and SNZ2" /db_xref="GeneID:850485" /db_xref="SGD:S000001835" ORIGIN 1 msefkvktgl aqmlkggvim dvvtpeqaii aeragacavm aleripadmr ksgqvcrmsd 61 prmikeimea vsipvmakvr ighfveaqil eelqvdyide sevltpadwt hhiekhnfkv 121 pfvcgakdlg ealrrinega amirtkgeag tgdvseavkh itkikaeiqq ykenlktesd 181 faakatelrv pvdllkttls egklpvvnfa aggvatpada allmqlgceg vfvgsgifks 241 sdpeklacai veatthydnp akllqvssdl gdlmggisiq sineaggkng arlseigw // LOCUS NP_116597 340 aa linear PLN 30-JUN-2025 DEFINITION 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116597 VERSION NP_116597.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179909.1 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 340) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12382. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..340 /product="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" /calculated_mol_wt="38461" Region 5..255 /region_name="PBP2_THI5" /note="Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily; cd13650" /db_xref="CDD:270368" Site order(12,44,89,114,118,159..160,167,201) /site_type="other" /note="putative chemical substrate binding site [chemical binding]" /db_xref="CDD:270368" CDS 1..340 /gene="THI5" /locus_tag="YFL058W" /coded_by="NM_001179909.1:1..1023" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:12777485]" /note="Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" /db_xref="GeneID:850486" /db_xref="SGD:S000001836" ORIGIN 1 mstdkitfll nwqptpyhip iflaqtkgyf keqgldmail eptnpsdvte ligsgkvdmg 61 lkamihtlaa kargfpvtsv aslldepftg vlylkgsgit edfqslkgkk igyvgefgki 121 qideltkhyg mkpedytavr cgmnvakyii egkidagigi ecmqqvelee ylakqgrpas 181 dakmlridkl aclgcccfct vlyicndefl kknpekvrkf lkaikkatdy vladpvkawk 241 eyidfkpqln ndlsykqyqr cyayfsssly nvhrdwkkvt gygkrlailp pdyvsnytne 301 ylswpepeev sdpleaqrlm aihqekcrqe gtfkrlalpa // LOCUS NP_116600 558 aa linear PLN 30-JUN-2025 DEFINITION Agp3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116600 VERSION NP_116600.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179912.1 REFERENCE 1 (residues 1 to 558) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 558) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 558) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 558) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12385. Method: conceptual translation. FEATURES Location/Qualifiers source 1..558 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..558 /product="Agp3p" /calculated_mol_wt="60921" Region 50..517 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..558 /gene="AGP3" /locus_tag="YFL055W" /coded_by="NM_001179912.1:1..1677" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006865 amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015171 amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:10654085]" /experiment="EXISTENCE:mutant phenotype:GO:0006865 amino acid transport [PMID:14697254]" /experiment="EXISTENCE:mutant phenotype:GO:0015171 amino acid transmembrane transporter activity [PMID:14697254]" /note="Low-affinity amino acid permease; may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition" /db_xref="GeneID:850489" /db_xref="SGD:S000001839" ORIGIN 1 mavlnlkret vdieetakkd ikpyfasnve avdidedpdv srydpqtgvk ralknrhisl 61 lalggvigpg clvgagnaln kggplalllg fsiigiiafs vmesigemit lypsgggftt 121 larrfhsdal pavcgyayvv vffavlaney ntlssilqfw gpqvplygyi lifwfafeif 181 qlvgvglfge teywlawlki vglvayyifs ivyisgdirn rpafgfhywn spgalshgfk 241 giaivfvfcs tfysgtesva laatesknpg kavplavrqt lwrilvvyig iavfygatvp 301 fddpnlsast kvlkspiaia isragwagga hlvnafilit cisaingsly igsrtlthla 361 heglapkila wtdrrgvpip aitvfnalgl islmnvsvga anaysyivnl sgvgvfivwg 421 visythlrir kawvaqgrsi eelpyealfy pwtpvlslaa niflaliqgw syfvpfdagn 481 fvdayillpv gillyigicv fksnhfrtvd lrsinldegr rkdmeadlsd qesslasset 541 mkdyksatff rylsnift // LOCUS NP_116601 646 aa linear PLN 30-JUN-2025 DEFINITION Aqy3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116601 VERSION NP_116601.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179913.1 REFERENCE 1 (residues 1 to 646) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 646) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 646) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 646) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12386. Method: conceptual translation. FEATURES Location/Qualifiers source 1..646 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..646 /product="Aqy3p" /calculated_mol_wt="70376" Region 348..557 /region_name="MIP" /note="Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; cd00333" /db_xref="CDD:238204" Site order(388,406..408,534..535,538,541) /site_type="active" /note="amphipathic channel [active]" /db_xref="CDD:238204" Site order(408..410,538..540) /site_type="other" /note="Asn-Pro-Ala signature motifs" /db_xref="CDD:238204" CDS 1..646 /gene="AQY3" /locus_tag="YFL054C" /coded_by="NM_001179913.1:1..1941" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015254 glycerol channel activity [PMID:12832087]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:12832087]" /note="Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol" /db_xref="GeneID:850490" /db_xref="SGD:S000001840" ORIGIN 1 msyesgrsss ssestrpptl keepngkiaw eesvkksren nendstllrr klgetrkaie 61 tggssrnkls altplkkvvd erkdsvqpqv psmgftyslp nlktlnsfsd aeqarimqdy 121 lsrgvnqgns nnyvdplyrq lnptmgssrn rpvwslnqpl phvldrglaa kmiqknmdar 181 srassrrgst disrggstts vkdwkrllrg aapgkklgdi eaqtqrdntv gadvkptkle 241 penpqkpsnt hienvsrkkk rtshnvnfsl gdesyassia daesrklknm qtldgstpvy 301 tklpeeliee enkstsaldg neigaseded adimtfpnfw akiryhmrep faeflgtlvl 361 vifgvggnlq atvtkgsggs yeslsfawgf gcmlgvyvag gisgghinpa vtismaifrk 421 fpwkkvpvyi vaqiigayfg gamaygyfws sitefeggph irttatgacl ftdpksyvtw 481 rnaffdefig asilvgclma llddsnappg ngmtaliigf lvaaigmalg yqtsftinpa 541 rdlgprifas migygphafh lthwwwtwga wggpiaggia galiydifif tgcespvnyp 601 dngyienrvg kllhaefhqn dgtvsdesgv nsnsntgskk svptss // LOCUS NP_116602 591 aa linear PLN 30-JUN-2025 DEFINITION dihydroxyacetone kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116602 VERSION NP_116602.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179914.1 REFERENCE 1 (residues 1 to 591) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 591) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 591) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 591) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12387. Method: conceptual translation. FEATURES Location/Qualifiers source 1..591 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..591 /product="dihydroxyacetone kinase" /EC_number="2.7.1.28" /EC_number="2.7.1.29" /calculated_mol_wt="62004" Region 4..586 /region_name="dak_ATP" /note="dihydroxyacetone kinase, ATP-dependent; TIGR02361" /db_xref="CDD:274097" CDS 1..591 /gene="DAK2" /locus_tag="YFL053W" /coded_by="NM_001179914.1:1..1776" /experiment="EXISTENCE:genetic interaction:GO:0004371 glycerone kinase activity [PMID:12401799]" /experiment="EXISTENCE:genetic interaction:GO:0061610 glycerol to glycerone phosphate metabolic process [PMID:22979944]" /experiment="EXISTENCE:mutant phenotype:GO:0004371 glycerone kinase activity [PMID:12401799]" /note="Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation" /db_xref="GeneID:850491" /db_xref="SGD:S000001841" ORIGIN 1 mshkqfksdg nivtpyllgl arsnpgltvi khdrvvfrta sapnsgnppk vslvsgggsg 61 hepthagfvg egaldaiaag aifaspstkq iysaikaves pkgtliivkn ytgdiihfgl 121 aaerakaagm kvelvavgdd vsvgkkkgsl vgrrglgatv lvhkiagaaa shglelaeva 181 evaqsvvdns vtiaasldhc tvpghkpeai lgeneyeigm gihnesgtyk ssplpsisel 241 vsqmlpllld ededrsyvkf epkedvvlmv nnmggmsnle lgyaaevise qlidkyqivp 301 krtitgafit alngpgfgit lmnaskaggd ilkyfdyptt asgwnqmyhs akdwevlakg 361 qvptapslkt lrnekgsgvk adydtfakil lagiakinev epkvtwydti agdgdcgttl 421 vsggealeea iknhtlrled aalgiediay mvedsmggts gglysiylsa laqgvrdsgd 481 keltaetfkk asnvaldaly kytrarpgyr tlidalqpfv ealkagkgpr aaaqaaydga 541 ektrkmdalv grasyvakee lrkldseggl pdpgavglaa lldgfvtaag y // LOCUS NP_116603 465 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding domain containing protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_116603 VERSION NP_116603.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179915.1 REFERENCE 1 (residues 1 to 465) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 465) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 465) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 465) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12388. Method: conceptual translation. FEATURES Location/Qualifiers source 1..465 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..465 /product="DNA-binding domain containing protein" /calculated_mol_wt="53110" Region 3..43 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(3,7,12..15,17,20,29) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(8,11,18,24,27,34) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 74..>366 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..465 /gene="ZNF1" /locus_tag="YFL052W" /coded_by="NM_001179915.1:1..1398" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:25673751]" /experiment="EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:25673751]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:25673751]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:25673751]" /experiment="EXISTENCE:mutant phenotype:GO:0071361 cellular response to ethanol [PMID:25673751]" /note="Zinc cluster transcription factor that regulates respiratory growth; binds to promoters of genes involved in respiration, gluconeogenesis, and the glyoxylate shunt; required for normal carbon source utilization and adaptation to pH, osmotic and ethanol stress especially during non-fermentative metabolism" /db_xref="GeneID:850492" /db_xref="SGD:S000001842" ORIGIN 1 marnrqacdc ccirrvkcdr kkpckcclqh nlqctylrpl kkrgpkpvkv rnlkkvddvq 61 vfsksssggi mkvpkalidq clrlyndkly viwpllcydd lyellekryd etcvywflvs 121 lsaatlsdlq teieseggvt ftgiqlssfc mssrqefddf ngsdifkimt yyclnrcyaq 181 msnsrtsyrl sceavglikl agfhreetlk llpfdeqqlg rkvyyllllt eryfsvythc 241 atsldttiap pqpenvtdpr lsldsflemi rvftvpgkcf fdalatdsan vtctedslkk 301 iwrelhtvpl eiepwsygyv disfsrhwir tlawklvlqi sgmrisflsn sknthipvei 361 ardmledtfl ipknlyavhg pgisvkalei adalvdvvnq ydqnaeseaw nflfdiskfv 421 fslkhcdstl vdkfttkcqc alitlplsnp lestdgsked vdalp // LOCUS NP_116576 160 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFL051C [Saccharomyces cerevisiae S288C]. ACCESSION NP_116576 VERSION NP_116576.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179916.1 REFERENCE 1 (residues 1 to 160) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 160) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 160) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12389. Method: conceptual translation. FEATURES Location/Qualifiers source 1..160 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..160 /product="uncharacterized protein" /calculated_mol_wt="17979" Region 125..>151 /region_name="PA14" /note="PA14 domain; cl08459" /db_xref="CDD:471833" CDS 1..160 /locus_tag="YFL051C" /coded_by="NM_001179916.1:1..483" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; SWAT-GFP fusion protein localizes to the cell periphery while mCherry fusion protein localizes to both the cell periphery and vacuole; YFL051C is not an essential gene" /db_xref="GeneID:850493" /db_xref="SGD:S000001843" ORIGIN 1 msiphsvfsa llvfvalatt tlasteaclp tnkredgmni nfyeytigdq ttylepeymg 61 yeysntkklg svsgqtnlsi yysppcestp tcvtyavlkr dedgydpcgp lyetkkrdte 121 ycdpntayws sdlfgfyttp tnvtvemtgy liwsmgnrrr // LOCUS NP_116604 858 aa linear PLN 30-JUN-2025 DEFINITION putative Mg(2+) transporter ALR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116604 VERSION NP_116604.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179917.1 REFERENCE 1 (residues 1 to 858) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 858) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 858) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 858) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 858) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 858) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 858) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 858) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12390. Method: conceptual translation. FEATURES Location/Qualifiers source 1..858 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..858 /product="putative Mg(2+) transporter ALR2" /calculated_mol_wt="96553" Region 455..796 /region_name="Alr1p-like" /note="Saccharomyces cerevisiae Alr1p-like subfamily; cd12829" /db_xref="CDD:213363" Site order(478,481..482,491,493,543,547,561,564,572,575,579, 585..586,589,604..605,608,611..612,615,619,690..691, 693..694,697..698,700..701,704..705,707..708,710..712, 722..729,731..743,745..747,749..754,756..763,772..773, 776..777,780,790,793) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:213363" Site order(547,561) /site_type="other" /note="putative Cl binding site [ion binding]" /db_xref="CDD:213363" Site order(739,742) /site_type="other" /note="hydrophobic gate" /db_xref="CDD:213363" Site order(757,759..760) /site_type="other" /note="periplasmic entrance" /db_xref="CDD:213363" CDS 1..858 /gene="ALR2" /locus_tag="YFL050C" /coded_by="NM_001179917.1:1..2577" /experiment="EXISTENCE:direct assay:GO:0015693 magnesium ion transport [PMID:12167543]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:9430719]" /experiment="EXISTENCE:mutant phenotype:GO:0006812 monoatomic cation transport [PMID:9430719]" /experiment="EXISTENCE:mutant phenotype:GO:0022890 inorganic cation transmembrane transporter activity [PMID:9430719]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:9430719]" /note="Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition" /db_xref="GeneID:850494" /db_xref="SGD:S000001844" ORIGIN 1 msslstsfds ssdlprsksv dntaasmktg kypklenyrq ysdaqpirhe alalkvdetk 61 dsrhkfsssn gensgvengg yvektnists grmdfegeae aeavkryqlr sfallssnar 121 psrlakseth qkqihvesia pslpknaale rghdtalpag tssnrcnlea sssartftsa 181 rkaslvsaif etsaesehgt hpkqaklkrr tystisthss vnpttlltrt asqksdmgnd 241 trrikplrmd srvsfhseis qasrdsqete edvcfpmfrl lhtrvngvdf deleeyaqis 301 naernlslan hqrhsertyn htdqdtgftn sastsgssaa lkytpeisrt lekncsvnem 361 yvsennesvr eddkpdlhpd vtfgrnkieg ekegndssys rayytlqnte yqipsrfsff 421 rsesdetvha sdipsliseg qtfyelfkgg dptwwldcsc ptddemrcia ktfgihplta 481 edirmqetre kvelfksyyf vcfhtfendk esenylepin vyivvfrsgv ltfhfdpish 541 canvrrrvrq lrdyvsvnsd wlcyaliddi tdsfapviqs ieyeadsidd svfmtrdmdf 601 aamlqriges rrktmtlmrl lsgkadvikm fakrcqdetn gigpvlksqt nmvnlqaeqe 661 nvnqnnsnnq islsnsymqt tsqprgdial ylgdiqdhll tmfqnllaye kifsrshany 721 laqlqvesfn snnkvtemlg kvtmlgtmlv plnvitglfg mnvkvpgrng siawwygilg 781 vllllavisw flasywikki dppatlneaa gsgaksviss flpkrdkrfn ddskngnarv 841 gvrrkstvsl psrysryn // LOCUS NP_116605 623 aa linear PLN 30-JUN-2025 DEFINITION Swp82p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116605 VERSION NP_116605.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179918.1 REFERENCE 1 (residues 1 to 623) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 623) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 623) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 623) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12391. Method: conceptual translation. FEATURES Location/Qualifiers source 1..623 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..623 /product="Swp82p" /calculated_mol_wt="70145" Region 83..219 /region_name="CRC_subunit" /note="Chromatin remodelling complex Rsc7/Swp82 subunit; pfam08624" /db_xref="CDD:430112" CDS 1..623 /gene="SWP82" /locus_tag="YFL049W" /coded_by="NM_001179918.1:1..1872" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:16204215]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:16204215|PMID:18644858|PMID:8127913|PMID:16464826]" /note="Member of the SWI/SNF chromatin remodeling complex; has an as yet unidentified role in the complex; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p; relocates to the cytosol under hypoxic conditions" /db_xref="GeneID:850495" /db_xref="SGD:S000001845" ORIGIN 1 mlgedegntv lekgnnpsvk qgevgavfiv pkilireher vilkqilqil dqdelvqppl 61 dkfpykklel pkyidelktr datntsykmi qldaygekkv gsngelfggr hylfntftft 121 ahmgvllvll qdvikvlyqs nathdedefi vqhdqilvme tseeqtkfla kngvipeesk 181 gsfkyitars afvefgasvi aggqrivddy weslakkqnl sshqrvfkls tnliskisll 241 rpsfqnnris naneisantn ntctistskf esqypivteq psaeireayi enfakgehis 301 aivpgqsisg tlelsaqfrv pryhsknsfq qalqmkamdi pigrheella qyesqapdgs 361 asislpnhip svnpsnkpik rmlssildin vsssknkkse enemikpmnk gqhknntsln 421 ingwkfeslp lksaensgkq qyyrglplye kntllerlkq ltpneikele hlhdavfvnt 481 glqnvrkvrt kkwkkywqyk agipiglkrs qldefknkyl kdvlaqtsvt tnfneitntd 541 etittkrvpn pnflgncnik dfkppyiysh vnkvpqnvag dktavkldte vkntnanpvv 601 atdpvaakpd nlanfsneva mnn // LOCUS NP_116606 445 aa linear PLN 30-JUN-2025 DEFINITION Emp47p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116606 VERSION NP_116606.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179919.1 REFERENCE 1 (residues 1 to 445) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 445) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 445) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 445) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12392. Method: conceptual translation. FEATURES Location/Qualifiers source 1..445 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..445 /product="Emp47p" /calculated_mol_wt="50199" Region 40..255 /region_name="lectin_EMP46_EMP47" /note="EMP46 and EMP47 type 1 transmembrane proteins, N-terminal lectin domain; cd06903" /db_xref="CDD:173891" Site order(113,238) /site_type="other" /note="carbohydrate binding site [chemical binding]" /db_xref="CDD:173891" Site order(158,168..169,173) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:173891" CDS 1..445 /gene="EMP47" /locus_tag="YFL048C" /coded_by="NM_001179919.1:1..1338" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12857885]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12857885]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:direct assay:GO:0097367 carbohydrate derivative binding [PMID:16439369]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:12857885]" /note="Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; forms a complex with Ssp120p that may function in trafficking plasma membrane glycoproteins through early secretory pathway; EMP47 has a paralog, EMP46, that arose from the whole genome duplication" /db_xref="GeneID:850496" /db_xref="SGD:S000001846" ORIGIN 1 mmmlitmkst vllsvftvla twaglleahp lgdtsdaskl ssdyslpdli narkvpnnwq 61 tgeqasleeg rivltskqns kgslwlkqgf dlkdsftmew tfrsvgysgq tdggisfwfv 121 qdsnvprdkq lyngpvnydg lqllvdnngp lgptlrgqln dgqkpvdktk iydqsfascl 181 mgyqdssvps tirvtydled dnllkvqvdn kvcfqtrkvr fpsgsyrigv taqngavnnn 241 aesfeifkmq ffngviedsl ipnvnamgqp klitkyidqq tgkekliekt afdadkdkit 301 nyelykkldr vegkilandi naletklndv ikvqqellsf mttitkqlss kppannekgt 361 stddaiaedk enfkdflsin qklekvlveq ekyreatkrh gqdgpqvdei arklmiwllp 421 lifimlvmay ytfrirqeii ktkll // LOCUS NP_428268 714 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein RGD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_428268 VERSION NP_428268.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179920.1 REFERENCE 1 (residues 1 to 714) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 714) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 714) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 714) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12393. Method: conceptual translation. FEATURES Location/Qualifiers source 1..714 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..714 /product="GTPase-activating protein RGD2" /calculated_mol_wt="82078" Region 6..96 /region_name="FCH" /note="Fes/CIP4 homology domain; smart00055" /db_xref="CDD:214492" Region 205..289 /region_name="DEP_fRgd2" /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGAP (GTPase-activator protein) Rgd2-like proteins. Rgd2-like proteins share a common domain architecture, containing, beside the RhoGAP domain, a DEP and a FCH (Fes/CIP4 homology) domain; cd04436" /db_xref="CDD:239883" Region 473..708 /region_name="RhoGAP_fRGD2" /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their...; cd04399" /db_xref="CDD:239864" Site order(512,562,566,660,663..664,690) /site_type="other" /note="putative GTPase interaction site [polypeptide binding]" /db_xref="CDD:239864" Site 512 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:239864" CDS 1..714 /gene="RGD2" /locus_tag="YFL047W" /coded_by="NM_001179920.1:1..2145" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:11591390]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:physical interaction:GO:0007264 small GTPase-mediated signal transduction [PMID:11591390]" /note="GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress" /db_xref="GeneID:850497" /db_xref="SGD:S000001847" ORIGIN 1 mlsfcdyfws edlvsgldvl fdrlyhgceq cdlfiqlfas rmqfevshgr qlfgieagmd 61 nlkavqeded egvtvsralr gilqemsqeg thhltiasni eslvlqpfsk wciehreriq 121 ysektlltnv nnfrkskkyv gklekeyfnk crqleefkrt hfnedelana mkslkiqnky 181 eedvarekdh rffnriagid fdyktmketl qllltklpkt dyklplisys lsntnnggei 241 tkflldhmsl kdidqaetfg qdllnlgflk ycngvgntfv nskkfqyqwk ntaymfanvp 301 mpgseepttg eslisrfnnw dgssakeiiq skigndqgaa kiqaphisdn ertlfrmmda 361 laasdkkyyq ecfkmdalrc sveellidhl sfmekcesdr lnaikkatld fcstlgnkis 421 slrlcidkml tlendidpta dllqllvkyk tgsfkpqaiv ynnyynpgsf qnfgvdletr 481 crldkkvvpl iissifsymd kiypdlpndk vrtsiwtdsv klslthqlrn llnkqqfhne 541 geifdilsts klepstiasv vkiyllelpd plipndvsdi lrvlyldypp lvetalqnst 601 sspenqqddd neegfdtkri rglyttlssl skphiatlda itthfyrlik ilkmgengne 661 vadeftvsis qefanciiqs kitddneigf kifydllthk kqifhelkrq nskn // LOCUS NP_116608 207 aa linear PLN 30-JUN-2025 DEFINITION Fmp32p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116608 VERSION NP_116608.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179921.1 REFERENCE 1 (residues 1 to 207) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 207) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 207) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 207) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12394. Method: conceptual translation. FEATURES Location/Qualifiers source 1..207 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..207 /product="Fmp32p" /calculated_mol_wt="23887" Region 32..206 /region_name="CCDC90-like" /note="Coiled-coil domain-containing protein 90-like; pfam07798" /db_xref="CDD:462268" CDS 1..207 /gene="FMP32" /locus_tag="YFL046W" /gene_synonym="PUT6" /coded_by="NM_001179921.1:1..624" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:26928762|PMID:24769239|PMID:14576278|P MID:12514182]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:32978391]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:25565209]" /experiment="EXISTENCE:mutant phenotype:GO:2000214 regulation of proline metabolic process [PMID:32978391]" /note="Regulator of mitochondrial proline metabolism; tethered with Put7p to inner mitochondrial membrane in large hetero-oligomeric complex, abundance of which is regulated by proline; involved in mitochondrial proline homeostasis and cellular redox balance; null exhibits pronounced defect in proline utilization, and can be functionally complemented by expression of human homolog MCUR1" /db_xref="GeneID:850498" /db_xref="SGD:S000001848" ORIGIN 1 mlkrivglpa rrcfhrtsfl lgsdfetvhi pntnhfkdll iengkfqedq attiveimtd 61 airggvnhvs qdlakreklt qlsyqqrvdf aklrdqllsa drsefhniqn eyesvkndle 121 klrnklreei tktnagfkld lslekgrire esshhdlqik eidtkieqev tnmkmqidsv 181 ktqvmqwlig vctgtfalvl aymrllt // LOCUS NP_116609 254 aa linear PLN 30-JUN-2025 DEFINITION phosphomannomutase SEC53 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116609 VERSION NP_116609.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179922.1 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 254) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12395. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..254 /product="phosphomannomutase SEC53" /EC_number="5.4.2.8" /calculated_mol_wt="28932" Region 12..>46 /region_name="OtsB" /note="Trehalose-6-phosphate phosphatase [Carbohydrate transport and metabolism]; COG1877" /db_xref="CDD:441481" Site order(19..23,28,52..54,58,130,135,141,148,183..186,188,196, 215..216,223..224) /site_type="active" /db_xref="CDD:319784" Region 35..254 /region_name="PMM" /note="Eukaryotic phosphomannomutase; pfam03332" /db_xref="CDD:397425" CDS 1..254 /gene="SEC53" /locus_tag="YFL045C" /gene_synonym="ALG4" /coded_by="NM_001179922.1:1..765" /experiment="EXISTENCE:direct assay:GO:0004615 phosphomannomutase activity [PMID:3288631]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:3905826]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /note="Phosphomannomutase; involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen; human homolog PMM2 complements yeast mutants" /db_xref="GeneID:850499" /db_xref="SGD:S000001849" ORIGIN 1 msiaefayke kpetlvlfdv dgtltparlt vseevrktla klrnkccigf vggsdlskql 61 eqlgpnvlde fdysfsengl tayrlgkela sqsfinwlge ekynklavfi lrylseidlp 121 krrgtflefr ngminvspig rnasteerne ferydkehqi rakfvealkk efpdygltfs 181 iggqisfdvf pagwdktycl qhvekdgfke ihffgdktmv ggndyeifvd ertighsvqs 241 pddtvkilte lfnl // LOCUS NP_116610 301 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease OTU1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116610 VERSION NP_116610.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179923.1 REFERENCE 1 (residues 1 to 301) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 301) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 301) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 301) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12396. Method: conceptual translation. FEATURES Location/Qualifiers source 1..301 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..301 /product="ubiquitin-specific protease OTU1" /EC_number="3.4.19.12" /calculated_mol_wt="33379" Region 1..300 /region_name="COG5539" /note="Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]" /db_xref="CDD:227826" CDS 1..301 /gene="OTU1" /locus_tag="YFL044C" /coded_by="NM_001179923.1:1..906" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:16427015]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:16427015]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:15755922]" /note="Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850500" /db_xref="SGD:S000001850" ORIGIN 1 mklkvtgagi nqvvtlkqda tlndliehin vdvktmrfgy ppqrinlqge daslgqtqld 61 elginsgeki tiessdsnes fslpppqpkp krvlkstems iggsgenvls vhpvlddnsc 121 lfhaiaygif kqdsvrdlre mvskevlnnp vkfndaildk pnkdyaqwil kmeswggaie 181 igiisdalav aiyvvdidav kiekfnedkf dnyililfng ihydsltmne fktvfnknqp 241 esddvltaal qlasnlkqtg ysfnthkaqi kcntcqmtfv gerevarhae stghvdfgqn 301 r // LOCUS NP_116611 674 aa linear PLN 30-JUN-2025 DEFINITION Lam5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116611 VERSION NP_116611.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179924.1 REFERENCE 1 (residues 1 to 674) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 674) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 674) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 674) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12397. Method: conceptual translation. FEATURES Location/Qualifiers source 1..674 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..674 /product="Lam5p" /calculated_mol_wt="76216" Region 209..302 /region_name="PH-GRAM_GRAMDC" /note="GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; cd13220" /db_xref="CDD:275406" Region 418..562 /region_name="VASt" /note="VAD1 Analog of StAR-related lipid transfer domain; pfam16016" /db_xref="CDD:464975" CDS 1..674 /gene="LAM5" /locus_tag="YFL042C" /gene_synonym="LTC2; YFL043C" /coded_by="NM_001179924.1:1..2025" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:26001273]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:26001273]" /note="Putative sterol transfer protein; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; localizes to membrane contact sites throughout the cell, including nucleus-vacuole junctions and ER-mitochondrial contact sites" /db_xref="GeneID:850501" /db_xref="SGD:S000001852" ORIGIN 1 msdvdnwepv sdnedstdsv kqlgppfeha snndnagdte aeslqevpln tetndvrknl 61 vvitnqsaad ehpteikhdq srtsstssff sgmissfksn vpspvsrstt ptspvsqpsi 121 ishrrepsmg skrrssrris natiaeigsp lqqvekpdev ktrltpsqmk ednydhrrfv 181 eerymdtpyh yaseqrnkdf hetfksvpkd drllddfncg lnrellyqgk lyitethlcf 241 nsnvlgwiak vliafedvtf mektsaaglf psaisietkm gktlfngfis rdaafglmke 301 vwsrtllqkd masenintka eksgngkeid dainsideen ndkdandndt nenddenist 361 nettpnstss spdkekekay klradssyqy dgpiyhhsts fpaepmanne fvlkelpfdc 421 apgilfeimf nseqneflld flrgqegsqi ttipnftsid gssmtlkrey syekalhfpa 481 gpksttcyva evikrkdpdt yyevissirt pnvpsggsfs tktrylirwn deitcllrvs 541 fwvewtgssw ikgmvengck ngqleaaqlm erilskfikn nveecqitis keeeeqddke 601 vknklkevdl eqpreavvta paiaeqqglk vtmetwlfly livvvlllfn lfyirsiavs 661 lhqlvklqlv elkl // LOCUS NP_878071 63 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFL041W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878071 VERSION NP_878071.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184549.1 REFERENCE 1 (residues 1 to 63) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 63) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 63) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 63) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12398. Method: conceptual translation. FEATURES Location/Qualifiers source 1..63 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..63 /product="uncharacterized protein" /calculated_mol_wt="7452" Region <11..49 /region_name="MDR" /note="Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; cl16912" /db_xref="CDD:450120" CDS 1..63 /locus_tag="YFL041W-A" /coded_by="NM_001184549.1:1..192" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466401" /db_xref="SGD:S000028547" ORIGIN 1 mkmwgpsqrd sfreitykvk fkyddgdysl aidlmsrdci nvyelitdrl lvdflskkll 61 klr // LOCUS NP_116612 622 aa linear PLN 30-JUN-2025 DEFINITION ferroxidase FET5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116612 VERSION NP_116612.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179925.1 REFERENCE 1 (residues 1 to 622) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 622) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 622) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 622) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12399. Method: conceptual translation. FEATURES Location/Qualifiers source 1..622 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..622 /product="ferroxidase FET5" /calculated_mol_wt="70749" Region 21..146 /region_name="CuRO_1_Fet3p" /note="The first Cupredoxin domain of multicopper oxidase Fet3P; cd13851" /db_xref="CDD:259920" Site order(34..35,37,40,42,50,81,122..127,133,135..137,140,142, 144) /site_type="other" /note="Domain 2 interface [polypeptide binding]" /db_xref="CDD:259920" Site order(79,81..82,84,86,91..94,96,98,100..103,126,128,130, 132..133,135) /site_type="other" /note="Domain 3 interface [polypeptide binding]" /db_xref="CDD:259920" Region 157..304 /region_name="CuRO_2_Fet3p_like" /note="The second Cupredoxin domain of multicopper oxidase Fet3P; cd13877" /db_xref="CDD:259945" Site order(158..161,165,192,195..198,202,212,214,216,239..241, 256,258,296,298..299) /site_type="other" /note="Domain 1 interface [polypeptide binding]" /db_xref="CDD:259945" Site order(221,223,235..236,238..242,244..246,248,252,254..259) /site_type="other" /note="Domain 3 interface [polypeptide binding]" /db_xref="CDD:259945" Region 341..515 /region_name="CuRO_3_Fet3p" /note="The third Cupredoxin domain of multicopper oxidase Fet3p; cd13899" /db_xref="CDD:259966" Site order(352,356,358,417,419,468..472,474,498..502,504..505) /site_type="other" /note="Domain 2 interface [polypeptide binding]" /db_xref="CDD:259966" Site order(367,370,373..375,421,423..426,471..472,489,492..494, 496,498,500,504,510) /site_type="other" /note="Domain 1 interface [polypeptide binding]" /db_xref="CDD:259966" CDS 1..622 /gene="FET5" /locus_tag="YFL041W" /coded_by="NM_001179925.1:1..1869" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:24390141|PMID:10608875]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:genetic interaction:GO:0004322 ferroxidase activity [PMID:9413439]" /experiment="EXISTENCE:mutant phenotype:GO:0006826 iron ion transport [PMID:9413439]" /note="Multicopper oxidase; integral membrane protein with similarity to Fet3p; targeted to vacuole via AP-3 pathway; may have role in iron transport" /db_xref="GeneID:850502" /db_xref="SGD:S000001853" ORIGIN 1 mlfysfvwsv laasvalakt hklnytaswv tanpdglhek rmigfngewp lpdihvekgd 61 rvelyltngf qdntatslhf hglfqntslg nqlqmdgpsm vtqcpivpgq tylynftvpe 121 qvgtfwyhah mgaqygdgmr gafiihdpee pfeydhervi tlsdhyheny ktvtkeflsr 181 ynptgaepip qnilfnntmn vtldftpget ylfrflnvgl fvsqyiiled hemsivevdg 241 vyvkpnftds iylsagqrms vlikakdkmp trnyammqim detmldvvpp elqlnqtiqm 301 ryghslpear alniedcdld ratndfylep lierdllahy dhqivmdvrm vnlgdgvkya 361 ffnnityvtp kvptlttllt sgklasdpri ygdninaqll khndiievvl nnydsgrhpf 421 hlhghnfqiv qkspgfhvde aydeseqdem tvpynesapl qpfperpmvr dtvvlepsgh 481 vvlrfradnp gvwyfhchvd whlqqglasv fieapvllqe reklnenyld ickaadipvv 541 gnaaghsndw fdlkglprqp eplpkgftte gylaliisti igvwglysia qygigevipn 601 dekvyhtlre ilaeneievs rg // LOCUS NP_116613 540 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFL040W [Saccharomyces cerevisiae S288C]. ACCESSION NP_116613 VERSION NP_116613.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179926.1 REFERENCE 1 (residues 1 to 540) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 540) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 540) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 540) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12400. Method: conceptual translation. FEATURES Location/Qualifiers source 1..540 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..540 /product="uncharacterized protein" /calculated_mol_wt="60479" Region 28..490 /region_name="MFS_HXT" /note="Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; cd17356" /db_xref="CDD:340914" Site order(39,43,160,163..164,167,286..287,291..292,295..296, 323,402..403,406..407,411,434..435,438) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..540 /locus_tag="YFL040W" /coded_by="NM_001179926.1:1..1623" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /note="Putative transporter; member of the sugar porter family; YFL040W is not an essential gene; may have a role in intracellular sterol transport" /db_xref="GeneID:850503" /db_xref="SGD:S000001854" ORIGIN 1 mtamkaivwr lpkmpkikit ktyevtkita iltlvgfimg levpslatfl tnktfneyfk 61 yptplqqgll mgstplggim gcficcimnd rfsriyqfqs giiiwnivtl lnfciwdilg 121 llicrmikgm ilgnfsilva syaneviprg krgstmsyiq lcltigilvm hylcialslw 181 dshfafriaw cigiipgllf wmasyalpes yhwlvlhgkm seaqeiqhnl akkfnesqpr 241 davpemskie lagdfwigvn dldfskklpr gsfkplilgm tlqllvqfsg iniilgyity 301 iceivglegn vklftssipy finmvlsllp itfidytsrk litllggfpi sgllitigal 361 fvkygqdtkp idgnrslvws igenpfvggw iltlcflivg ifamslssip wvytnemlps 421 rvkvkgfaic vtfgwlgnfi ltflcpvmie rlkgttfiif gsltflisls vliwfpetkg 481 msiedidkff efeskegtnl hgekgiktpd snsnggstrs sqegqlhkpi klksdeemii // LOCUS NP_116614 375 aa linear PLN 30-JUN-2025 DEFINITION actin [Saccharomyces cerevisiae S288C]. ACCESSION NP_116614 VERSION NP_116614.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179927.1 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 375) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12401. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..375 /product="actin" /calculated_mol_wt="41559" Region 6..370 /region_name="ASKHA_NBD_actin" /note="nucleotide-binding domain (NBD) of actin and similar proteins; cd10224" /db_xref="CDD:466823" CDS 1..375 /gene="ACT1" /locus_tag="YFL039C" /gene_synonym="ABY1; END7" /coded_by="NM_001179927.1:1..1128" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:3967297|PMID:8163554]" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:16299513|PMID:14690608|PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:6217414]" /experiment="EXISTENCE:direct assay:GO:0005884 actin filament [PMID:6217414]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:8245125]" /experiment="EXISTENCE:direct assay:GO:0030476 ascospore wall assembly [PMID:17118118]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:6365930|PMID:3967297|PMID:8163554]" /experiment="EXISTENCE:direct assay:GO:0032432 actin filament bundle [PMID:3967297|PMID:6365930|PMID:8163554]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:10911987|PMID:15485911]" /experiment="EXISTENCE:genetic interaction:GO:0009306 protein secretion [PMID:10793147]" /experiment="EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:9864365]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:8978821]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8590801]" /experiment="EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:10793147]" /experiment="EXISTENCE:mutant phenotype:GO:1902404 mitotic actomyosin contractile ring contraction [PMID:9732290]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245|PMID:10952318]" /note="Actin, structural protein in cytoskeleton; involved in cell polarization, endocytosis, and other cytoskeletal functions; monomeric actin in the nucleus plays a role in INO80 chromatin remodeling" /db_xref="GeneID:850504" /db_xref="SGD:S000001855" ORIGIN 1 mdsevaalvi dngsgmckag fagddaprav fpsivgrprh qgimvgmgqk dsyvgdeaqs 61 krgiltlryp iehgivtnwd dmekiwhhtf ynelrvapee hpvllteapm npksnrekmt 121 qimfetfnvp afyvsiqavl slyssgrttg ivldsgdgvt hvvpiyagfs lphailridl 181 agrdltdylm kilsergysf sttaereivr dikeklcyva ldfeqemqta aqsssieksy 241 elpdgqviti gnerfrapea lfhpsvlgle sagidqttyn simkcdvdvr kelygnivms 301 ggttmfpgia ermqkeital apssmkvkii apperkysvw iggsilaslt tfqqmwiskq 361 eydesgpsiv hhkcf // LOCUS NP_116615 206 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase YPT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116615 VERSION NP_116615.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179928.1 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 206) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12402. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..206 /product="Rab family GTPase YPT1" /calculated_mol_wt="23083" Region 7..172 /region_name="Rab1_Ypt1" /note="Rab GTPase family 1 includes the yeast homolog Ypt1; cd01869" /db_xref="CDD:206661" Site 7..10 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206661" Site 15..22 /site_type="other" /note="G1 box" /db_xref="CDD:206661" Site order(16,18..23,33,121..122,124,151..153) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206661" Site order(23..34,37..39) /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206661" Site order(33,38..46) /site_type="other" /note="Switch I region" /db_xref="CDD:206661" Site order(38,42..49,56,58) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206661" Site 40 /site_type="other" /note="G2 box" /db_xref="CDD:206661" Site order(41,43..45,60,62,69..70,73,77,79..82,169) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206661" Site order(41..42,44,62..63,70,72,74..76,79) /site_type="active" /note="GDI interaction site [active]" /db_xref="CDD:206661" Site 41..45 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206661" Site 58..62 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206661" Site 63..66 /site_type="other" /note="G3 box" /db_xref="CDD:206661" Site order(66,68..78) /site_type="other" /note="Switch II region" /db_xref="CDD:206661" Site 69..74 /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206661" Site 77..81 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206661" Site 86..91 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206661" Site 112..118 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206661" Site 121..124 /site_type="other" /note="G4 box" /db_xref="CDD:206661" Site 151..153 /site_type="other" /note="G5 box" /db_xref="CDD:206661" Site 167..172 /site_type="other" /note="Rab subfamily motif 4 (RabSF4)" /db_xref="CDD:206661" CDS 1..206 /gene="YPT1" /locus_tag="YFL038C" /coded_by="NM_001179928.1:1..621" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:10747087]" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:18388317]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:20375281]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:3311726|PMID:9447979]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10747087]" /experiment="EXISTENCE:direct assay:GO:0005795 Golgi stack [PMID:12802060]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:26906739]" /experiment="EXISTENCE:direct assay:GO:0031410 cytoplasmic vesicle [PMID:23129774]" /experiment="EXISTENCE:direct assay:GO:0035493 SNARE complex assembly [PMID:8603910]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:18388317]" /experiment="EXISTENCE:genetic interaction:GO:0048194 Golgi vesicle budding [PMID:18388317]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:7593181|PMID:2504726|PMID:15689495]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:18388317]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20375281]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20375281]" /experiment="EXISTENCE:mutant phenotype:GO:0032456 endocytic recycling [PMID:20059749]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:26195667]" /experiment="EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:20059749]" /experiment="EXISTENCE:mutant phenotype:GO:0035494 SNARE complex disassembly [PMID:9157884]" /experiment="EXISTENCE:mutant phenotype:GO:0048211 Golgi vesicle docking [PMID:9545229]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]" /experiment="EXISTENCE:mutant phenotype:GO:0090114 COPII-coated vesicle budding [PMID:15689495]" /experiment="EXISTENCE:mutant phenotype:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:22844259]" /experiment="EXISTENCE:mutant phenotype:GO:1990261 pre-mRNA catabolic process [PMID:22844259]" /experiment="EXISTENCE:physical interaction:GO:0000149 SNARE binding [PMID:18388317]" /note="Rab family GTPase; involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by type II protein geranylgeranyltransferase (Bet2p-Bet4p); binds to unspliced HAC1 mRNA; regulates the unfolded protein response (UPR) by promoting the decay of HAC1 RNA; localizes to the early Golgi, the transitional Golgi and ER membranes, pre-autophagosomal structures, and cytoplasmic vesicles" /db_xref="GeneID:850505" /db_xref="SGD:S000001856" ORIGIN 1 mnseydylfk lllignsgvg ksclllrfsd dtytndyist igvdfkiktv eldgktvklq 61 iwdtagqerf rtitssyyrg shgiiivydv tdqesfngvk mwlqeidrya tstvlkllvg 121 nkcdlkdkrv veydvakefa dankmpflet saldstnved afltmarqik esmsqqnlne 181 ttqkkedkgn vnlkgqsltn tgggcc // LOCUS NP_116616 457 aa linear PLN 30-JUN-2025 DEFINITION beta-tubulin [Saccharomyces cerevisiae S288C]. ACCESSION NP_116616 VERSION NP_116616.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179929.1 REFERENCE 1 (residues 1 to 457) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 457) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 457) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 457) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12403. Method: conceptual translation. FEATURES Location/Qualifiers source 1..457 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..457 /product="beta-tubulin" /calculated_mol_wt="50792" Region 2..426 /region_name="beta_tubulin" /note="The beta-tubulin family; cd02187" /db_xref="CDD:276956" Site order(2,131,245..247,251,256,258..260,322..324,327, 347..351) /site_type="other" /note="beta/alpha domain interface [polypeptide binding]" /db_xref="CDD:276956" Site order(10..12,15,138,140..144,181,204,222,226) /site_type="other" /note="nucleotide binding site [chemical binding]" /db_xref="CDD:276956" Site order(22..23,26..27,215,224,227..228,234,270,272..274, 358..360) /site_type="other" /note="Taxol binding site [chemical binding]" /db_xref="CDD:276956" Site order(70..71,98..100,103,179,181,222) /site_type="other" /note="alpha/beta domain interface [polypeptide binding]" /db_xref="CDD:276956" CDS 1..457 /gene="TUB2" /locus_tag="YFL037W" /gene_synonym="ARM10; SHE8" /coded_by="NM_001179929.1:1..1374" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:9488492]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:15469986]" /experiment="EXISTENCE:direct assay:GO:0045298 tubulin complex [PMID:9488492]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:12181356]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:8171338]" /experiment="EXISTENCE:mutant phenotype:GO:0031122 cytoplasmic microtubule organization [PMID:8171338|PMID:12181356]" /experiment="EXISTENCE:mutant phenotype:GO:0090307 mitotic spindle assembly [PMID:12181356|PMID:7806575]" /experiment="EXISTENCE:physical interaction:GO:0045298 tubulin complex [PMID:9488492]" /note="Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria" /db_xref="GeneID:850506" /db_xref="SGD:S000001857" ORIGIN 1 mreiihistg qcgnqigaaf weticgehgl dfngtyhghd diqkerlnvy fneassgkwv 61 prsinvdlep gtidavrnsa ignlfrpdny ifgqssagnv wakghytega elvdsvmdvi 121 rreaegcdsl qgfqithslg ggtgsgmgtl liskireefp drmmatfsvl pspktsdtvv 181 epynatlsvh qlvehsdetf cidnealydi cqrtlklnqp sygdlnnlvs svmsgvttsl 241 rypgqlnsdl rklavnlvpf prlhffmvgy apltaigsqs frsltvpelt qqmfdaknmm 301 aaadprngry ltvaaffrgk vsvkevedem hkvqsknsdy fvewipnnvq tavcsvapqg 361 ldmaatfian stsiqelfkr vgdqfsamfk rkaflhwyts egmdelefse aesnmndlvs 421 eyqqyqeatv eddeevdeng dfgapqnqde pitenfe // LOCUS NP_116617 1351 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116617 VERSION NP_116617.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179930.1 REFERENCE 1 (residues 1 to 1351) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1351) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1351) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 1351) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12404. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1351 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..1351 /product="DNA-directed RNA polymerase" /EC_number="2.7.7.6" /calculated_mol_wt="152917" Region 415..1228 /region_name="PHA00452" /note="T3/T7-like RNA polymerase" /db_xref="CDD:222797" Region 855..1351 /region_name="RNA_pol" /note="DNA-dependent RNA polymerase; pfam00940" /db_xref="CDD:460006" CDS 1..1351 /gene="RPO41" /locus_tag="YFL036W" /coded_by="NM_001179930.1:1..4056" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:26184436|PMID:3517858|PMID:2426263]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:3517858|PMID:2426263]" /experiment="EXISTENCE:direct assay:GO:0006269 DNA replication, synthesis of primer [PMID:26184436]" /experiment="EXISTENCE:direct assay:GO:0006390 mitochondrial transcription [PMID:21911502]" /experiment="EXISTENCE:direct assay:GO:0034245 mitochondrial DNA-directed RNA polymerase complex [PMID:7929382]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:3517858]" /experiment="EXISTENCE:mutant phenotype:GO:0006390 mitochondrial transcription [PMID:3517858]" /note="Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation; synthesizes RNA primers for mitochondrial DNA replication; capable of DNA-primed RNA extension, resulting in 5' input DNA with extended RNA on the 3' end" /db_xref="GeneID:850507" /db_xref="SGD:S000001858" ORIGIN 1 mlrpaykslv ktsllqrrli sskgsklfkp spdststili sedplvtgss ptssttsgii 61 ssndfplfnk nrkdakssis yqwknpsele fdpfnkshas avtsmtrtrd vmqlwsllea 121 clqsnlmkra fsileslylv pehkqrfied ynmylnsfsk ndpnfpilkm nekltndlet 181 sfkdvnyndk tlaimihhal nfhsttssml lkpiisaylk msvngireif scldiltisd 241 lnilmndlkv itpsqlpnsv rpilesltls ptpvnniene eglnkveaen dsklhkasna 301 ssdsikkpsl dplrevsfhg stevlskdae kliavdtigm rvirhtllgl sltpeqkeqi 361 skfkfdandn vlkmkptknd dnnnsinffe iynslptlee kkafesalni fnqdrqkvle 421 nrateaarer wkhdfeeaka rgdisieknl nvklwkwyne mlplvkeein hcrsllsekl 481 sdkkglnkvd tnrlgygpyl tlidpgkmcv itilellkln stggviegmr taravisvgk 541 aiemefrseq vlksesqafr dvnkkspefk klvqnaksvf rssqieqski lwpqsirari 601 gsvlismliq vakvsvqgvd pvtkakvhge apafahgyqy hngsklgvlk ihktlirqln 661 gerliasvqp qllpmlvepk pwvnwrsggy hytqstllrt kdspeqvayl kaasdngdid 721 rvydglnvlg rtpwtvnrkv fdvvsqvwnk gegfldipga qdemvlppap pknsdpsilr 781 awklqvktia nkfssdrsnr cdtnykleia raflgeklyf phnldfrgra yplsphfnhl 841 gndmsrglli fwhgkklgps glkwlkihls nlfgfdklpl kdrvaftesh lqdikdsaen 901 pltgdrwwtt adkpwqalat cfelnevmkm dnpeefishq pvhqdgtcng lqhyaalggd 961 vegatqvnlv psdkpqdvya hvarlvqkrl eiaaekgden akilkdkitr kvvkqtvmtn 1021 vygvtyvgat fqiakqlspi fddrkesldf skyltkhvfs airelfhsah liqdwlgesa 1081 krisksirld vdeksfkngn kpdfmssviw ttplglpivq pyreeskkqv etnlqtvfis 1141 dpfavnpvna rrqkaglppn fihsldashm llsaaecgkq gldfasvhds ywthasdidt 1201 mnvvlreqfi klhevdlvlr lkeefdqryk nyvkigklkr stdlaqkiir irkdlsrklg 1261 rsttladeiy fekkrqelln spliedrnvg ekmvttvslf editdldale lenggdensg 1321 msvllplrlp eippkgdfdv tvlrnsqyff s // LOCUS NP_116618 287 aa linear PLN 30-JUN-2025 DEFINITION Mob2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116618 VERSION NP_116618.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179931.1 REFERENCE 1 (residues 1 to 287) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 287) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 287) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 287) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12405. Method: conceptual translation. FEATURES Location/Qualifiers source 1..287 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..287 /product="Mob2p" /calculated_mol_wt="33145" Region 102..271 /region_name="Mob1_phocein" /note="Mob1/phocein family; pfam03637" /db_xref="CDD:461000" CDS 1..287 /gene="MOB2" /locus_tag="YFL034C-B" /gene_synonym="YFL035C; YFL035C-A" /coded_by="NM_001179931.1:1..864" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12196508|PMID:11747810]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12196508]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11747810]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12196508|PMID:11747810]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:12196508]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:11747810]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:12196508|PMID:11747810]" /experiment="EXISTENCE:mutant phenotype:GO:0001934 positive regulation of protein phosphorylation [PMID:12196508]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0007163 establishment or maintenance of cell polarity [PMID:12196508]" /note="Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p" /db_xref="GeneID:850508" /db_xref="SGD:S000001859" ORIGIN 1 msffnfkafg rnskknknqp lnvaqppamn tiyssphssn srlslrnkhh spkrhsqtsf 61 paqkstpqsq qltsttpqsq qqeaserses qqimflsepf vrtalvkgsf ktivqlpkyv 121 dlgewialnv fefftnlnqf ygvvaeyvtp dayptmnagp htdylwldan nrqvslpasq 181 yidlaltwin nkvndknlfp tknglpfpqq fsrdvqrimv qmfrifahiy hhhfdkivhl 241 sleahwnsff shfisfakef kiidrkemap llpliesfek qgkiiyn // LOCUS NP_116619 122 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL22 RPL22B [Saccharomyces cerevisiae S288C]. ACCESSION NP_116619 VERSION NP_116619.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184310.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 122) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12406. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..122 /product="60S ribosomal protein eL22 RPL22B" /calculated_mol_wt="13695" Region 16..110 /region_name="Ribosomal_L22e" /note="Ribosomal L22e protein family; pfam01776" /db_xref="CDD:460321" CDS 1..122 /gene="RPL22B" /locus_tag="YFL034C-A" /gene_synonym="YFL035C-B" /coded_by="NM_001184310.1:1..369" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:27478489]" /note="Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; autoregulates splicing of its pre-m-RNA; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22B has a paralog, RPL22A, that arose from the whole genome duplication" /db_xref="GeneID:850509" /db_xref="SGD:S000006436" ORIGIN 1 mapntsrkqk viktltvdvs sptengvfdp asyskylidh ikvdgavgnl gnaievtedg 61 sivtvvssak fsgkylkylt kkylkknqlr dwirfvsirq nqyklvfyqv tpedadeeed 121 de // LOCUS NP_116583 1073 aa linear PLN 30-JUN-2025 DEFINITION Mil1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116583 VERSION NP_116583.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179932.2 REFERENCE 1 (residues 1 to 1073) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1073) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1073) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 1073) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1073) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1073) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1073) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1073) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12407. On Apr 26, 2011 this sequence version replaced NP_116583.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1073 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..1073 /product="Mil1p" /calculated_mol_wt="119380" Region 541..875 /region_name="DUF726" /note="Protein of unknown function (DUF726); pfam05277" /db_xref="CDD:368366" CDS 1..1073 /gene="MIL1" /locus_tag="YFL034W" /coded_by="NM_001179932.2:1..3222" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:26658609]" /experiment="EXISTENCE:direct assay:GO:0035650 AP-1 adaptor complex binding [PMID:26658609]" /experiment="EXISTENCE:mutant phenotype:GO:0035652 clathrin-coated vesicle cargo loading [PMID:26658609]" /note="Predicted lipase; binds variant medium clathrin chain Apm2p and contributes to its membrane recruitment; putative integral membrane protein that interacts with Rpp0p component of ribosomal stalk" /db_xref="GeneID:850510" /db_xref="SGD:S000001860" ORIGIN 1 msdseedlgv qlkglkiarh lkesgehtde esnsspehdc glsnqddltv mhtqakeevf 61 krreedgtrt edalhegeag kegtgfpssq svcspneads gidradkpil ldpfksvhdt 121 dpvpgtksrs nsdsdsdsdd ggwqempavs sfniynhrge leltskvrns eqasetsptv 181 ppgkncksvn dsrfdytkma aeqqaqrsyr tnkktdflfd hkvlkkkins sqtsvnltss 241 psttslnnek nnddddddsy deyeddvepv ndlnrdsqln itknllsdme kfayvgaini 301 lanqmctnla tlclcidiks hkklahrlqf tqkdmaawkt vvlsrlydhl gisqeeivmi 361 eklslhkiql edlckclktt qsidnpwend rdheedgiee ttermspneq ngsvqastpd 421 peqsatpetp kakqsplssd vpgkvldpen vksqdklnid vawtiicdlf liclqsstyd 481 srsrtllinf akvlnmtsle iceferrvtd sldmeqsted qvwdeqdhmr nrrrskrrkk 541 mayvalamvg gslvlglsgg llapvigggi aaglstigit gatsfltgvg gttvvavsst 601 aiganigarg mskrmgsvrt fefrplhnnr rvnliltvsg wmvgneddvr lpfstvdpve 661 gdlyslywep emlksigqtv sivateiftt slqqilgatv ltalissiqw pmalsklgyi 721 ldnpwnvsld rawsagkila dtliarnlga rpitlvgfsi garvifscli elckkkalgl 781 ienvylfgtp avmkkeqlvm arsvvsgrfv ngysdkdwfl aylfraaagg fsavmgisti 841 envegienin ctefvdghln yrksmpkllk rigiavlsee fveieemmnp eevkrkrkli 901 ndvdaaqkkl serkkhnswv pkwlkpkksk wkvmveeave egrdmqdlpe ndvnnnenen 961 pdehegiarq krrdaalvdh galmhelqli kqamhedeik nkaclpgedk evessndflg 1021 eshykppstp kinppqspnn fqllsagrti lpedddfdpr gkkkvefsfp ddi // LOCUS NP_116620 1770 aa linear PLN 30-JUN-2025 DEFINITION protein kinase RIM15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116620 VERSION NP_116620.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179933.1 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1770) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12408. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..1770 /product="protein kinase RIM15" /EC_number="2.7.11.1" /calculated_mol_wt="196401" Region 797..1260 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(800..803,806,808,821,823,856,872..875,918,927..928, 964,985,1064) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270762" Region 1255..>1298 /region_name="S_TK_X" /note="Extension to Ser/Thr-type protein kinases; smart00133" /db_xref="CDD:214529" Region 1637..1746 /region_name="REC_hyHK_CKI1_RcsC-like" /note="phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; cd17546" /db_xref="CDD:381099" Site order(1643,1645..1646,1648..1649,1652..1653,1656,1718,1736, 1738..1739) /site_type="other" /note="Hpt domain binding site [polypeptide binding]" /db_xref="CDD:381099" CDS 1..1770 /gene="RIM15" /locus_tag="YFL033C" /gene_synonym="TAK1" /coded_by="NM_001179933.1:1..5313" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:24140345|PMID:9111339|PMID:9744870|PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:23273919|PMID:20471941]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690612]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:14690612]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:25660547]" /experiment="EXISTENCE:genetic interaction:GO:0010508 positive regulation of autophagy [PMID:25660547]" /experiment="EXISTENCE:genetic interaction:GO:1903452 positive regulation of G1 to G0 transition [PMID:23273919]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:20471941]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:25660547]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:25660547]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:38539794]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:23861665]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9111339]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:9111339]" /experiment="EXISTENCE:mutant phenotype:GO:0070301 cellular response to hydrogen peroxide [PMID:38539794]" /experiment="EXISTENCE:mutant phenotype:GO:1901992 positive regulation of mitotic cell cycle phase transition [PMID:23861665]" /experiment="EXISTENCE:mutant phenotype:GO:1903452 positive regulation of G1 to G0 transition [PMID:9744870|PMID:20471941]" /note="Protein kinase involved in cell proliferation in response to nutrients; glucose-repressible; involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; phosphorylates Igo1p and Igo2p; substrate of Pho80p-Pho85p kinase" /db_xref="GeneID:850511" /db_xref="SGD:S000001861" ORIGIN 1 mfnrsntagg sqamkeglgi nklspissns npssltssny ekylqlatek npcmilelel 61 dgkvrygspq wntitgvadd sgssptyiad lilgsdqdkg vfqkatdmll mnddtsctit 121 fkikaadyeg sagcddesti ttleargili rdghtqlpsh tmwivkprtn dwsdfyaned 181 aqddmviqls dncddidiql peefaktlgf gakifvqylk rirlemiide fnlplpkmel 241 crvcenfvpv wwlethsqsc vcehrtesli qllhdnlleq qailanftkd seykgsqiqv 301 rsnnflnqvl dslrelcqda idinpsemvp dlyhslstfp qdngnnnnnn nnnnnnnnal 361 ldqfpiqkdt vslnsyfqfs prtnhniqnv tswqsrffln ddqdpglall ihdtldlark 421 kvdavlrldn amtyslkikn evnnyvvqli reqieinkha ilthpmnlrs ssifhsplpq 481 ihsqqpeaen liyssstplq vqhdqcasfe apskshlepi pfpvssieet ptandirhps 541 plprscsntv mklptprrkl dsnglfsday lnadiipnps iestisidrd nntnsrgssm 601 kqygigeatd srtsnserps ssssrlgirs rsitprqkie yshvdnddrt nemlsrdkds 661 lqpqpsvdtt itsstqattt gtktnsnnst nsvlpklmts isltprrgsp sfgnlashsm 721 qqtnsfklih dkspisspft fskdfltpeq hpsniartds innamltspn mplsplllat 781 nqtvksptps ikdydilkpi skgaygsvyl arkkltgdyf aikvlrksdm iaknqvtnvk 841 seraimmvqs dkpyvarlfa sfqnkdnlfl vmeylpggdl atlikmmgyl pdqwakqylt 901 eivvgvndmh qngiihhdlk penllidnag hvkltdfgls raglirrhkf vphksslsis 961 stlpidnpan nftmnnnnsn hsqlstpdsf tsdhkqynrs kksslgqqye hseysstsns 1021 hsmtptpstn tvvypsyyrg kdrshgssni dlpaslrrse sqlsfslldi srsstpplan 1081 ptnsnannim rrksltenks fsndllssda iaatntnins nnnislspap sdlalfypdd 1141 skqnkkffgt pdylapetie gkgednkqcd wwsvgciffe lllgyppfha etpdavfkki 1201 lsgviqwpef kneeeerefl tpeakdliek llvvdpakrl gakgiqeikd hpyfknvdwd 1261 hvydeeasfv ptidnpedtd yfdlrgaelq dfgddiendn anilfgkhgi ntdvselsaa 1321 nlspplnhkn ilsrklsmsn ttnrssnnsn ssvhdfgaht pvnklsiasv lesvpqetgy 1381 itpngtgttt tsaknspnlk nlslaipphm rdrrssklnd sqtefgsfnf rnlsaldkan 1441 kdainrlkse hfseqpgvhr rtssaslmgs ssdgsvstpg snasnttsgg klkihkptis 1501 gspstfgtfp ktflrsdsfs trsyspersi sidsstlsrk gsiigdnqqt tanssdsptm 1561 tkfksplspa ntttvssyfs rqrvlsksfs qrtnssdlsa eesdrlqais rvnslrnrrr 1621 sgrkssstse igyhmdvlvc epipihryrv tkdlenlgct vvsvgagdel vsratsgvsf 1681 dlimtalklp klgaidivql lkqtnganst tpivaitnyf qeaatsrvfd dvlekpvkld 1741 elkklvakya lkksqedeeh tilsdsdeth // LOCUS NP_116622 238 aa linear PLN 30-JUN-2025 DEFINITION transcription factor HAC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116622 VERSION NP_116622.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179935.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 238) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12409. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..238 /product="transcription factor HAC1" /calculated_mol_wt="26774" Region 41..91 /region_name="bZIP_HAC1-like" /note="Basic leucine zipper (bZIP) domain of Fungal HAC1-like transcription factors: a DNA-binding and dimerization domain; cd14710" /db_xref="CDD:269858" Region 42..91 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269858" Site order(45..46,48..50,52..57,59..61) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269858" Site order(60,63..64,67..68,70..71,74..75,77..78,81..82,84..85, 88..89,91) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269858" CDS 1..238 /gene="HAC1" /locus_tag="YFL031W" /gene_synonym="ERN4; IRE15" /coded_by="NM_001179935.1:1..717" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15141165]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:15141165|PMID:9077435]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8898193]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9077435]" /experiment="EXISTENCE:direct assay:GO:0051321 meiotic cell cycle [PMID:15141165]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15141165]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:15141165|PMID:9077435]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16582425|PMID:8898193]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:26966233]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8898193|PMID:9077435]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:15141165]" /note="Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates unfolded protein response via UPRE binding and membrane biogenesis; translation initiation repressed under non-stress conditions by un-spliced intron that interacts with 5'-UTR; under ER stress Ire1p nuclease cleaves out inhibitory intron and triggers efficient Hac1p translation; two functional forms of Hac1p are produced; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850513" /db_xref="SGD:S000001863" ORIGIN 1 memtdfelts nsqsnlaipt nfkstlpprk raktkeekeq rrierilrnr raahqsrekk 61 rlhlqylerk csllenllns vnlekladhe daltcshdaf vasldeyrdf qstrgasldt 121 rasshsssdt ftpsplnctm epatlspksm rdsasdqets welqmfkten vpesttlpav 181 dnnnlfdava spladplcdd iagnslpfdn sidldnwrnp eaqsglnsfe lndffits // LOCUS NP_116623 385 aa linear PLN 30-JUN-2025 DEFINITION alanine--glyoxylate transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116623 VERSION NP_116623.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179936.1 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 385) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12410. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..385 /product="alanine--glyoxylate transaminase" /EC_number="2.6.1.44" /calculated_mol_wt="41776" Region 7..378 /region_name="AGAT_like" /note="Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); cd06451" /db_xref="CDD:99744" Site order(21,24,31,33,66..67,73,100,103,107..108,200,207,234, 257..260,334) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:99744" Site order(67..69,97,148,175,177,200..201) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99744" Site 201 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99744" CDS 1..385 /gene="AGX1" /locus_tag="YFL030W" /coded_by="NM_001179936.1:1..1158" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008453 alanine-glyoxylate transaminase activity [PMID:16226833]" /experiment="EXISTENCE:direct assay:GO:0019265 glycine biosynthetic process, by transamination of glyoxylate [PMID:16226833]" /experiment="EXISTENCE:mutant phenotype:GO:0008453 alanine-glyoxylate transaminase activity [PMID:14745783]" /note="Alanine:glyoxylate aminotransferase (AGT); catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; similar to mammalian and plant alanine:glyoxylate aminotransferases; human homolog AGXT complements yeast null mutant" /db_xref="GeneID:850514" /db_xref="SGD:S000001864" ORIGIN 1 mtksvdtlli pgpiilsgav qkaldvpslg htspefvsif qrvlkntrav fksaaasksq 61 pfvlagsgtl gwdifasnfi lskapnknvl vvstgtfsdr fadclrsyga qvdvvrplki 121 gesvplelit eklsqnsyga vtvthvdtst avlsdlkais qaikqtspet ffvvdavcsi 181 gceefefdew gvdfaltasq kaigapagls islcssrfmd yalndskngh vhgyfsslrr 241 wtpimenyea gkgayfatpp vqlinsldva lkeileeglh krwdlhrems dwfkdslvng 301 lqltsvsryp snmsahglta vyvadppdvi aflkshgvvi aggihkdigp kyirighmgv 361 tacnknlpym kncfdlikla lqrkk // LOCUS NP_116624 368 aa linear PLN 30-JUN-2025 DEFINITION cyclin-dependent protein kinase-activating kinase CAK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116624 VERSION NP_116624.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179937.1 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 368) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12411. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..368 /product="cyclin-dependent protein kinase-activating kinase CAK1" /EC_number="2.7.11.22" /calculated_mol_wt="42055" Region 13..>234 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Region <135..363 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" CDS 1..368 /gene="CAK1" /locus_tag="YFL029C" /gene_synonym="CIV1" /coded_by="NM_001179937.1:1..1107" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9819350]" /experiment="EXISTENCE:direct assay:GO:0097472 cyclin-dependent protein kinase activity [PMID:10373527|PMID:8752211|PMID:8752210|PMID:8781234]" /experiment="EXISTENCE:genetic interaction:GO:0060633 negative regulation of transcription initiation by RNA polymerase II [PMID:19269370]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:8752211|PMID:8752210]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:11739722]" /experiment="EXISTENCE:mutant phenotype:GO:0097472 cyclin-dependent protein kinase activity [PMID:8781234|PMID:8752211|PMID:8752210|PMID:10373527]" /note="Cyclin-dependent kinase-activating kinase; required for passage through the cell cycle; phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases; required for premeiotic DNA synthesis, expression of early and middle sporulation specific genes and direct phosphorylation of the Smk1p MAPK to regulate spore morphogenesis" /db_xref="GeneID:850515" /db_xref="SGD:S000001865" ORIGIN 1 mkldsidith cqlvkstrta riyrsdtyai kclaldfdip phnakfevsi lnklgnkckh 61 ilplleskat dnndllllfp feemnlyefm qmhykrdrrk knpyydllnp sipivadppv 121 qkytnqldvn ryslsffrqm vegiaflhen kiihrdikpq nimltnntst vspklyiidf 181 gisydmanns qtsaepmdsk vtdistgiyk apevlfgvkc ydggvdvwsl liiisqwfqr 241 etsrmghvpa middgsddmn sdgsdfrlic sifeklgips iqkweevaqh gsvdafvgmf 301 gadgdgkyvl dqekdvqisi vernmprlde iadvkvkqkf incilgmvsf spnerwscqr 361 ilqelekp // LOCUS NP_116625 289 aa linear PLN 30-JUN-2025 DEFINITION putative ATP-binding cassette family ATPase CAF16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116625 VERSION NP_116625.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179938.1 REFERENCE 1 (residues 1 to 289) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 289) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 289) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 289) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12412. Method: conceptual translation. FEATURES Location/Qualifiers source 1..289 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..289 /product="putative ATP-binding cassette family ATPase CAF16" /calculated_mol_wt="32959" Region 8..226 /region_name="ABC_ATPase" /note="ATP-binding cassette transporter nucleotide-binding domain; cd00267" /db_xref="CDD:213179" Site 41..48 /site_type="other" /note="Walker A/P-loop" /db_xref="CDD:213179" Site order(44..45,47..49,148,173..174,207) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:213179" Site order(124,146..148) /site_type="other" /note="Q-loop/lid" /db_xref="CDD:213179" Site 149..158 /site_type="other" /note="ABC transporter signature motif" /db_xref="CDD:213179" Site 169..174 /site_type="other" /note="Walker B" /db_xref="CDD:213179" Site 177..180 /site_type="other" /note="D-loop" /db_xref="CDD:213179" Site 203..209 /site_type="other" /note="H-loop/switch region" /db_xref="CDD:213179" CDS 1..289 /gene="CAF16" /locus_tag="YFL028C" /coded_by="NM_001179938.1:1..870" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0030014 CCR4-NOT complex [PMID:11113136]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11113136]" /note="Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator" /db_xref="GeneID:850516" /db_xref="SGD:S000001866" ORIGIN 1 mvsqfaievr nltykfkess dpsvvdinlq ipwntrslvv gangagkstl lkllsgkhlc 61 ldgkilvngl dpfsplsmnq vdddesveds tnyqtttylg tewchmsiin rdigvlellk 121 sigfdhfrer gerlvrildi dvrwrmhrls dgqkrrvqla mgllkpwrvl lldevtvdld 181 viararllef lkwetetrrc svvyathifd glakwpnqvy hmksgkivdn ldyqkdvefs 241 evvnakvngq vafendnnkv viskvnslhp lalewlkrdn qipdkeigi // LOCUS NP_444296 497 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein GYP8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_444296 VERSION NP_444296.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179939.1 REFERENCE 1 (residues 1 to 497) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 497) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 497) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 497) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12413. Method: conceptual translation. FEATURES Location/Qualifiers source 1..497 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..497 /product="GTPase-activating protein GYP8" /calculated_mol_wt="57488" Region 2..497 /region_name="COG5210" /note="GTPase-activating protein [General function prediction only]" /db_xref="CDD:227535" CDS 1..497 /gene="GYP8" /locus_tag="YFL027C" /coded_by="NM_001179939.1:1..1494" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:12189143]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12189143]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:12189143]" /note="GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport; localizes to the ER and peroxisomes" /db_xref="GeneID:850517" /db_xref="SGD:S000001867" ORIGIN 1 mplrslfhtn qsshdkdalt rggynayles lsrcdsgkae eqkgkviskl lekkdvralr 61 yiglgplgfv nnslrkdcwy ellasqllid dateyitpve khkdegqvil daersfggiv 121 dknlklqlrk llvelitrvl rkyptlnyyq gyhdivsvfi mcfswnvtke nglelenlsl 181 qeeidmerlf ycieaftlly lrdfmmnsld fsfeqlrvis slikesnmkf ynlfkfdene 241 plfaigsilt ifahnlkpid sgdnnlhkil fqifdmtism qsmrlpliiy knlllqnase 301 iskqieansd ffendfdlrh gaiqtvlqkk lydealweev lqitrkdatt askkalkrvs 361 lnkysallnt acgkpgcfdm stiifylseq tkmnehykee kyhgvaarsk tralvqrlgh 421 flpskynrws kislligiva ilyqlrttrs lslvlnlrym istklkdlsh ininlhhvsh 481 iwvdpirdil klghptr // LOCUS NP_116627 431 aa linear PLN 30-JUN-2025 DEFINITION alpha-factor pheromone receptor STE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116627 VERSION NP_116627.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179940.2 REFERENCE 1 (residues 1 to 431) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 431) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 431) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 431) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12414. On Apr 26, 2011 this sequence version replaced NP_116627.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..431 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..431 /product="alpha-factor pheromone receptor STE2" /calculated_mol_wt="47718" Region 21..297 /region_name="STE2" /note="Fungal pheromone mating factor STE2 GPCR; pfam02116" /db_xref="CDD:426608" CDS 1..431 /gene="STE2" /locus_tag="YFL026W" /coded_by="NM_001179940.2:1..1296" /experiment="EXISTENCE:direct assay:GO:0000755 cytogamy [PMID:17369365]" /experiment="EXISTENCE:direct assay:GO:0004934 mating-type alpha-factor pheromone receptor activity [PMID:2161538]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:2839507]" /experiment="EXISTENCE:genetic interaction:GO:0004934 mating-type alpha-factor pheromone receptor activity [PMID:9742115]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3037311]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:17369365]" /experiment="EXISTENCE:mutant phenotype:GO:0004934 mating-type alpha-factor pheromone receptor activity [PMID:9742115|PMID:6360378]" /note="Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells" /db_xref="GeneID:850518" /db_xref="SGD:S000001868" ORIGIN 1 msdaapslsn lfydptynpg qstinytsiy gngstitfde lqglvnstvt qaimfgvrcg 61 aaaltlivmw mtsrsrktpi fiinqvslfl iilhsalyfk yllsnyssvt yaltgfpqfi 121 srgdvhvyga tniiqvllva sietslvfqi kviftgdnfk riglmltsis ftlgiatvtm 181 yfvsavkgmi vtyndvsatq dkyfnastil lassinfmsf vlvvklilai rsrrflglkq 241 fdsfhillim scqsllvpsi ifilayslkp nqgtdvlttv atllavlslp lssmwataan 301 nasktntits dfttstdrfy pgtlssfqtd sinndakssl rsrlydlypr rkettsdkhs 361 ertfvsetad dieknqfyql ptptsskntr igpfadasyk egevepvdmy tpdtaadeea 421 rkfwtednnn l // LOCUS NP_116628 1029 aa linear PLN 30-JUN-2025 DEFINITION Bst1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116628 VERSION NP_116628.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179941.1 REFERENCE 1 (residues 1 to 1029) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1029) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1029) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 1029) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1029) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1029) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1029) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1029) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12415. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1029 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..1029 /product="Bst1p" /calculated_mol_wt="117625" Region 132..369 /region_name="PGAP1" /note="PGAP1-like protein; pfam07819" /db_xref="CDD:369540" Site 234..238 /site_type="active" /note="nucleophilic elbow [active]" /db_xref="CDD:238382" CDS 1..1029 /gene="BST1" /locus_tag="YFL025C" /gene_synonym="PER17" /coded_by="NM_001179941.1:1..3090" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8862519|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006505 GPI anchor metabolic process [PMID:14734546]" /experiment="EXISTENCE:genetic interaction:GO:0050185 phosphatidylinositol deacylase activity [PMID:14734546]" /experiment="EXISTENCE:mutant phenotype:GO:0006621 protein retention in ER lumen [PMID:8862519]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8862519]" /experiment="EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:8862519]" /experiment="EXISTENCE:mutant phenotype:GO:0034368 protein-lipid complex remodeling [PMID:27325793]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11673477]" /note="GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; functional ortholog of human PGAP1, mutation of which is associated with intellectual disability and encephalopathy" /db_xref="GeneID:850519" /db_xref="SGD:S000001869" ORIGIN 1 mgirrlvsvi trpiinkvns sgqysrvlat redqdkaspk ymnndkiakk pytyrlfsil 61 gilsicslll isllkpfnga dapqcesiym fpsyaridgf derytplahk yhlylyreqs 121 vdreplngde lqldgipvlf ipgnagsfrq crsiasacsn iyfdsntrat lrnenvrnld 181 fftadfnedf tafhgetmld qaeylndaik yilslyertp dyphpkpqsv iivghsmggi 241 vsrvmltlkn hvpgsistil tlssphaasp vtfdgdilkl ykntneywrk qlsqndsffs 301 knislvsitg gildttlpad yasvedlvsl engftsfttt ipdvwtpidh laivwckqlr 361 evlarllles idaskpekvk plnqrlqiar klllsgfedy swmnsklnyp qenlqefsdn 421 ffsdyatlem ndvldfemfn lekwhnnytk inipsnisst ehlhftllts ldmpmiyfct 481 esrvnlscit avdsiltvpr sskdtqfaad ssfgeaknpf kavsvgknil qkydylmisk 541 ptygefseqe gmednqgfll allrnvsnvq ivnttpsqil lfgeqlhldg kdieqvisfs 601 nlwdsllsyk letkieasne giaseetlfq pfirqwvyep feskwhlnii nksldinmhn 661 vapfiplnes eprslqlsff ippgmsleak mtinwsltlk mlfiryrlal asfpvafial 721 vlsyqfywyn ktsefpsfds tlgyilrkhg ilmfftlfla spvvnnklvq rilylldpvg 781 lnypfllser nmhanfyylg irdwfmstig ilfgvmtvgl lalvskifgs leilviflqr 841 klskkntedk eafdtiehka ygkgrlmasv lllllvffhi pyqmafvisl viqiatcirv 901 allklsnneq klnllnynmt llllllfvsa inipiiivfl hnvaikwets frshhnilav 961 apiiflvgnn sifkmpnsvp ldtwdgkvti ilfvyltvfs fiygirnlyw ihhlvniica 1021 wllffetih // LOCUS NP_116629 832 aa linear PLN 30-JUN-2025 DEFINITION Epl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116629 VERSION NP_116629.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179942.1 REFERENCE 1 (residues 1 to 832) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 832) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 832) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 832) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12416. Method: conceptual translation. FEATURES Location/Qualifiers source 1..832 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..832 /product="Epl1p" /calculated_mol_wt="96607" Region 56..197 /region_name="EPL1" /note="Enhancer of polycomb-like; pfam10513" /db_xref="CDD:463128" CDS 1..832 /gene="EPL1" /locus_tag="YFL024C" /coded_by="NM_001179942.1:1..2499" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:10911987|PMID:17274630]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807|PMID:15610740]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0032777 piccolo histone acetyltransferase complex [PMID:12782659]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911|PMID:10911987]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:22539722]" /note="Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb; coding sequence contains length polymorphisms in different strains" /db_xref="GeneID:850520" /db_xref="SGD:S000001870" ORIGIN 1 mptpsnaiei ndgshksgrs trrsgsrsah ddgldsfskg dsgagasags snsrfrhrki 61 svkqhlkiyl pndlkhldkd elqqrevvei etgvekneek evhlhrilqm gsghtkhkdy 121 iptpdasmtw neydkfytgs fqettsyikf satvedccgt nynmderdet flneqvnkgs 181 sdiltedefe ilcssfehai herqpflsmd pesilsfeel kptliksdma dfnlrnqlnh 241 einshkthfi tqfdpvsqmn trpliqliek fgskiydywr erkievngye ifpqlkferp 301 gekeeidpyv cfrrrevrhp rktrridiln sqrlralhqe lknakdlall vakrenvsln 361 windelkifd qrvkiknlkr slnisgeddd linhkrkrpt ivtveqreae lrkaelkraa 421 aaaaaakakn nkrnnqledk ssrltkqqqq qllqqqqqqq qnalktengk qlanasssst 481 sqpitshvyv klpsskipdi vledvdalln skeknarkfv qekmekrkie dadvffnltd 541 dpfnpvfdms lpknfstsnv pfasiasskf qidrsfyssh lpeylkgisd diriydsngr 601 srnkdnynld tkrikktely dpfqenleih sreypikfrk rvgrsnikyv drmpnfttss 661 tksacslmdf vdfdsiekeq ysregsndtd sinvydskyd efvrlydkwk ydspqneygi 721 kfsdeparln qisndtqvir fgtmlgtksy eqlreatiky rrdyitrlkq khiqhlqqqq 781 qqqqqqqqqa qqqkqksqnn nsnssnslkk lndslinsea kqnssitqkn ss // LOCUS NP_683715 796 aa linear PLN 30-JUN-2025 DEFINITION prefoldin-like protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_683715 VERSION NP_683715.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179943.1 REFERENCE 1 (residues 1 to 796) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 796) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 796) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 796) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12417. Method: conceptual translation. FEATURES Location/Qualifiers source 1..796 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..796 /product="prefoldin-like protein" /calculated_mol_wt="91291" Region 8..126 /region_name="Prefoldin" /note="Prefoldin subunit; pfam02996" /db_xref="CDD:427096" Region 12..42 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467470" Region 82..110 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467470" Region 714..788 /region_name="DUF3835" /note="Domain of unknown function (DUF3835); pfam12927" /db_xref="CDD:463753" CDS 1..796 /gene="BUD27" /locus_tag="YFL023W" /gene_synonym="URI1" /coded_by="NM_001179943.1:1..2391" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:18959479]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:19387492]" /experiment="EXISTENCE:genetic interaction:GO:0001731 formation of translation preinitiation complex [PMID:19387492]" /experiment="EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:19387492]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:32503921]" /experiment="EXISTENCE:mutant phenotype:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:32503921]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:32503921]" /experiment="EXISTENCE:mutant phenotype:GO:1990113 RNA polymerase I assembly [PMID:23459708]" /experiment="EXISTENCE:mutant phenotype:GO:1990114 RNA polymerase II core complex assembly [PMID:23459708]" /experiment="EXISTENCE:mutant phenotype:GO:1990115 RNA polymerase III assembly [PMID:23459708]" /experiment="EXISTENCE:mutant phenotype:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:32503921]" /note="Unconventional prefoldin protein involved in translation initiation; required for correct assembly of RNAP I, II, and III in an Rpb5p-dependent manner; shuttles between nucleus and cytoplasm; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding; mutations affect TOR signaling; ortholog of human URI/RMP" /db_xref="GeneID:850521" /db_xref="SGD:S000001871" ORIGIN 1 mdllaasves tlknlqdkrn flseqrehyi dirsrlvrfi ndnddgeeeg egqgmvfgdi 61 iistskiyls lgyeyyvekt keeaitfvdd klklmedaie qfnlkieeak ktldnlnhme 121 dgngieedea nndedflpsm eireelddeg nvisssvtpt tkqpsqsnsk keqtpavgpk 181 ekglakekks ksfeenlkgk llkrndevkk kvqpskvdte nvytfadlvq qmdqqdeled 241 gyietdeiny dydafensnf kvndnyeedd ededeeeyln hsiipgfeaq ssflqqiqrl 301 raqkqsqdhe reegdvnksl kpilkkssfa ensdkkqkkk qvgfasslei hevenlkeen 361 krqmqsfavp myetqestgi ankmtsdefd gdlfakmlgv qeadevheky keelinqerl 421 egeasrsnrr trvsrfrkdr askkentlst fkqettrsve nevvekepvv gdiiekepvv 481 gdviekepvv gdviekepav tdiverepav ndiverkpvv gdiiekepti ndivekepei 541 nsksefetpf kkkklkslqk prssksmkkk fdpkilenis dddydddddg nkkllsnksk 601 nntdeqdkfp skiqevsrsm aktgatvgse pvritnvdyh alggnlddmv kayslglydd 661 dleedpgtiv ekledfkeyn kqvellrdei rdfqlenkpv tmeeeendgn vmndiiehef 721 pesytndede valhpgrlqe evaieyrrlk eataskwqss spaahtegel epidkfgnpv 781 ktsrfrsqrl hmdskp // LOCUS NP_116631 503 aa linear PLN 30-JUN-2025 DEFINITION phenylalanine--tRNA ligase subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_116631 VERSION NP_116631.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179944.2 REFERENCE 1 (residues 1 to 503) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 503) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 503) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 503) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12418. Method: conceptual translation. FEATURES Location/Qualifiers source 1..503 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..503 /product="phenylalanine--tRNA ligase subunit alpha" /EC_number="6.1.1.20" /calculated_mol_wt="57381" Region 1..486 /region_name="PTZ00326" /note="phenylalanyl-tRNA synthetase alpha chain; Provisional" /db_xref="CDD:240361" CDS 1..503 /gene="FRS2" /locus_tag="YFL022C" /coded_by="NM_001179944.2:1..1512" /experiment="EXISTENCE:direct assay:GO:0004826 phenylalanine-tRNA ligase activity [PMID:166841|PMID:16162501]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006432 phenylalanyl-tRNA aminoacylation [PMID:166841|PMID:16162501]" /experiment="EXISTENCE:direct assay:GO:0009328 phenylalanine-tRNA ligase complex [PMID:3049607]" /experiment="EXISTENCE:mutant phenotype:GO:0002161 aminoacyl-tRNA deacylase activity [PMID:27226603]" /note="Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar" /db_xref="GeneID:850522" /db_xref="SGD:S000001872" ORIGIN 1 msdfqleilk kldeldeiks tlatfpqhgs qdvlsalnsl kahnklefsk vdtvtydltk 61 egaqilnegs yeiklvkliq elgqlqikdv msklgpqvgk vgqarafkng wiaknasnel 121 elsaklqntd lneltdetqs ilaqiknnsh ldsidakiln dlkkrkliaq gkitdfnvtk 181 gpefstdltk letdltsdmv stnaykdlkf kpynfnsqgv qissgalhpl nkvreefrqi 241 ffsmgftemp snqyvetgfw nfdalyvpqq hpardlqdtf yikdpltadl pddktymdni 301 kavheqgrfg sigyrynwkp eecqklvlrt hstaisarml hdlakdpkpt rlfsidrvfr 361 neavdathla efhqvegvla dynitlgdli kfmeefferm gvtglrfkpt ynpytepsme 421 ifswheglqk wveignsgmf rpemlesmgl pkdlrvlgwg lslerptmik ykvqnirell 481 ghkvsldfie tnpaarlded lye // LOCUS NP_116632 510 aa linear PLN 30-JUN-2025 DEFINITION Gat1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116632 VERSION NP_116632.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179945.1 REFERENCE 1 (residues 1 to 510) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 510) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 510) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 510) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12419. Method: conceptual translation. FEATURES Location/Qualifiers source 1..510 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..510 /product="Gat1p" /calculated_mol_wt="56197" Region 1..495 /region_name="GAT1" /note="GATA Zn-finger-containing transcription factor [Transcription]; COG5641" /db_xref="CDD:227928" CDS 1..510 /gene="GAT1" /locus_tag="YFL021W" /gene_synonym="MEP80; NIL1" /coded_by="NM_001179945.1:1..1533" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10799523]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10799523]" /experiment="EXISTENCE:genetic interaction:GO:0043565 sequence-specific DNA binding [PMID:7568152]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7568152]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9106207]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7568152]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:19380492]" /note="Transcriptional activator of nitrogen catabolite repression genes; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p; different translational starts produce two major and two minor isoforms that are differentially regulated and localized" /db_xref="GeneID:850523" /db_xref="SGD:S000001873" ORIGIN 1 mhvffpllfr pspvlfiaca yiyidiyihc trctvvnitm stnrvpnldp dlnlnkeiwd 61 lyssaqkilp dsnrilnlsw rlhnrtsfhr inrimqhsns imdfsaspfa sgvnaagpgn 121 ndlddtdtdn qqfflsdmnl ngssvfenvf ddddddddve thsivhsdll ndmdsasqra 181 shnasgfpnf ldtscsssfd dhfiftnnlp flnnnsinnn hshnsshnnn spsianntna 241 ntntntsast ntnspllrrn pspsivkpgs rrnssvrkkk palkkiksst svqssatpps 301 ntssnpdikc sncttsttpl wrkdpkglpl cnacglflkl hgvtrplslk tdiikkrqrs 361 stkinnnitp ppssslnpga agkkknytas vaaskrknsl nivaplksqd ipipkiasps 421 ipqylrsntr hhlsssvpie aetfssfrpd mnmtmnmnlh nastssfnne afwkpldsai 481 dhhsgdtnpn snmnttpngn lsldwlnlnl // LOCUS NP_116633 122 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116633 VERSION NP_116633.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179946.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 122) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12420. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..122 /product="seripauperin PAU5" /calculated_mol_wt="12714" Region 25..117 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..122 /gene="PAU5" /locus_tag="YFL020C" /coded_by="NM_001179946.1:1..369" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18312373]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:18312373]" /note="Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme" /db_xref="GeneID:850524" /db_xref="SGD:S000001874" ORIGIN 1 mvkltsiaag vaaiaagasa aatttlsqsd ervnlvelgv yvsdirahla eyysfqaahp 61 tetypveiae avfnygdftt mltgipadqv trvitgvpwy ssrlkpaiss alsadgiyti 121 an // LOCUS NP_001335772 117 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFL019C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335772 VERSION NP_001335772.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348831.1 REFERENCE 1 (residues 1 to 117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 117) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80292. Method: conceptual translation. FEATURES Location/Qualifiers source 1..117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..117 /product="uncharacterized protein" /calculated_mol_wt="13616" CDS 1..117 /locus_tag="YFL019C" /coded_by="NM_001348831.1:1..354" /note="hypothetical protein; conserved across S. cerevisiae strains; YFL019C is not an essential gene" /db_xref="GeneID:850525" /db_xref="SGD:S000001875" ORIGIN 1 mivelysnii evrryttkds lcsifesgst shfeinqlqv krlnllqnqf asvftsfhpk 61 dntkgihinf fspvtritdl qysffytnqi lfgtrylikm iqnfvtgkvf trtnqsk // LOCUS NP_116635 499 aa linear PLN 30-JUN-2025 DEFINITION dihydrolipoyl dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116635 VERSION NP_116635.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179948.1 REFERENCE 1 (residues 1 to 499) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 499) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 499) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 499) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12421. Method: conceptual translation. FEATURES Location/Qualifiers source 1..499 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..499 /product="dihydrolipoyl dehydrogenase" /EC_number="1.8.1.4" /calculated_mol_wt="53879" Region 24..498 /region_name="Pyr_redox_2" /note="Pyridine nucleotide-disulphide oxidoreductase; cl39093" /db_xref="CDD:476868" CDS 1..499 /gene="LPD1" /locus_tag="YFL018C" /gene_synonym="HPD1" /coded_by="NM_001179948.1:1..1500" /experiment="EXISTENCE:direct assay:GO:0004148 dihydrolipoyl dehydrogenase (NADH) activity [PMID:2821168]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10869431|PMID:11926067]" /experiment="EXISTENCE:direct assay:GO:0045252 oxoglutarate dehydrogenase complex [PMID:2072900]" /experiment="EXISTENCE:direct assay:GO:0045254 pyruvate dehydrogenase complex [PMID:12756305]" /experiment="EXISTENCE:genetic interaction:GO:0042743 hydrogen peroxide metabolic process [PMID:17110466]" /experiment="EXISTENCE:mutant phenotype:GO:0004148 dihydrolipoyl dehydrogenase (NADH) activity [PMID:3528755]" /experiment="EXISTENCE:mutant phenotype:GO:0004375 glycine dehydrogenase (decarboxylating) activity [PMID:7498764]" /experiment="EXISTENCE:mutant phenotype:GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity [PMID:3528755]" /experiment="EXISTENCE:mutant phenotype:GO:0005960 glycine cleavage complex [PMID:7498764]" /experiment="EXISTENCE:mutant phenotype:GO:0006090 pyruvate metabolic process [PMID:3528755]" /experiment="EXISTENCE:mutant phenotype:GO:0006103 2-oxoglutarate metabolic process [PMID:3528755]" /experiment="EXISTENCE:mutant phenotype:GO:0006546 glycine catabolic process [PMID:7498764]" /experiment="EXISTENCE:mutant phenotype:GO:0006550 L-isoleucine catabolic process [PMID:1479341]" /experiment="EXISTENCE:mutant phenotype:GO:0006552 L-leucine catabolic process [PMID:1479341]" /experiment="EXISTENCE:mutant phenotype:GO:0006564 L-serine biosynthetic process [PMID:7498764]" /experiment="EXISTENCE:mutant phenotype:GO:0006574 L-valine catabolic process [PMID:1479341]" /experiment="EXISTENCE:mutant phenotype:GO:0042743 hydrogen peroxide metabolic process [PMID:17110466]" /experiment="EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:3528755]" /note="Dihydrolipoamide dehydrogenase; the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes; PDH complex is concentrated in spots within the mitochondrial matrix, often near the ERMES complex and near peroxisomes; LPD1 has a paralog, IRC15, that arose from the whole genome duplication" /db_xref="GeneID:850527" /db_xref="SGD:S000001876" ORIGIN 1 mlrirsllnn krafsstvrt ltinkshdvv iigggpagyv aaikaaqlgf ntacvekrgk 61 lggtclnvgc ipskallnns hlfhqmhtea qkrgidvngd ikinvanfqk akddavkqlt 121 ggiellfkkn kvtyykgngs fedetkirvt pvdglegtvk edhildvkni ivatgsevtp 181 fpgieideek ivsstgalsl keipkrltii gggiiglemg svysrlgskv tvvefqpqig 241 asmdgevaka tqkflkkqgl dfklstkvis akrnddknvv eivvedtktn kqenleaevl 301 lvavgrrpyi aglgaekigl evdkrgrlvi ddqfnskfph ikvvgdvtfg pmlahkaeee 361 giaavemlkt ghghvnynni psvmyshpev awvgkteeql keagidykig kfpfaansra 421 ktnqdtegfv kilidskter ilgahiigpn agemiaeagl aleygasaed varvchahpt 481 lseafkeanm aaydkaihc // LOCUS NP_116636 77 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SMX2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116636 VERSION NP_116636.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180864.1 REFERENCE 1 (residues 1 to 77) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 77) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 77) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 77) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12422. Method: conceptual translation. FEATURES Location/Qualifiers source 1..77 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..77 /product="mRNA splicing protein SMX2" /calculated_mol_wt="8351" Region 3..75 /region_name="Sm_G" /note="Sm protein G; cd01719" /db_xref="CDD:212466" Site order(6,10,18,23,36,60,62..63,65,68..72,74) /site_type="other" /note="heptamer interface [polypeptide binding]" /db_xref="CDD:212466" Site order(15..21,23..35,37..41) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212466" Site order(35,37,64,66) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:212466" Site 60..71 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212466" CDS 1..77 /gene="SMX2" /locus_tag="YFL017W-A" /gene_synonym="SNP2; YFL018W-A" /coded_by="NM_001180864.1:1..234" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720285|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245|PMID:9012791]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /note="Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G" /db_xref="GeneID:850528" /db_xref="SGD:S000002965" ORIGIN 1 mvstpelkky mdkkillnin gsrkvagilr gydiflnvvl ddameinged pannhqlglq 61 tvirgnsiis lealdai // LOCUS NP_116637 159 aa linear PLN 30-JUN-2025 DEFINITION glucosamine 6-phosphate N-acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116637 VERSION NP_116637.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179949.1 REFERENCE 1 (residues 1 to 159) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 159) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 159) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 159) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12423. Method: conceptual translation. FEATURES Location/Qualifiers source 1..159 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..159 /product="glucosamine 6-phosphate N-acetyltransferase" /EC_number="2.3.1.4" /calculated_mol_wt="18004" Region 5..155 /region_name="N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate" /note="NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members...; cl17182" /db_xref="CDD:473072" Site order(100..102,112..113) /site_type="other" /note="Coenzyme A binding pocket [chemical binding]" /db_xref="CDD:173926" CDS 1..159 /gene="GNA1" /locus_tag="YFL017C" /gene_synonym="PAT1" /coded_by="NM_001179949.1:1..480" /experiment="EXISTENCE:direct assay:GO:0004343 glucosamine 6-phosphate N-acetyltransferase activity [PMID:9867860]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006048 UDP-N-acetylglucosamine biosynthetic process [PMID:9867860]" /experiment="EXISTENCE:mutant phenotype:GO:0006048 UDP-N-acetylglucosamine biosynthetic process [PMID:9867860]" /note="Glucosamine-6-phosphate acetyltransferase; evolutionarily conserved; required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA" /db_xref="GeneID:850529" /db_xref="SGD:S000001877" ORIGIN 1 mslpdgfyir rmeegdleqv tetlkvlttv gtitpesfsk likywneatv wndnedkkim 61 qynpmvivdk rtetvaatgn iiierkiihe lglcghiedi avnskyqgqg lgkllidqlv 121 tigfdygcyk iildcdeknv kfyekcgfsn agvemqirk // LOCUS NP_116638 511 aa linear PLN 30-JUN-2025 DEFINITION Mdj1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116638 VERSION NP_116638.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179950.1 REFERENCE 1 (residues 1 to 511) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 511) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 511) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 511) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12424. Method: conceptual translation. FEATURES Location/Qualifiers source 1..511 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..511 /product="Mdj1p" /calculated_mol_wt="55430" Region 61..448 /region_name="DnaJ_bact" /note="chaperone protein DnaJ; TIGR02349" /db_xref="CDD:274090" CDS 1..511 /gene="MDJ1" /locus_tag="YFL016C" /coded_by="NM_001179950.1:1..1536" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:9973563]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:15383543]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9973563]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:10567545]" /experiment="EXISTENCE:mutant phenotype:GO:0006458 'de novo' protein folding [PMID:8168133]" /experiment="EXISTENCE:mutant phenotype:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:7957078]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:8603724]" /experiment="EXISTENCE:mutant phenotype:GO:0042026 protein refolding [PMID:8168133]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:8943361]" /note="Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones" /db_xref="GeneID:850530" /db_xref="SGD:S000001878" ORIGIN 1 mafqqgvlsr csgvfrhhvg hsrhinnily rhaiafasia pripkssfht sairnneafk 61 dpydtlglkk satgaeikka yyklakkyhp dinkepdaek kfhdlqnaye ilsdetkrqq 121 ydqfgpaafg gggaaggagg gsgspfgsqf hdfsgftsag gspfgginfe dlfgaafggg 181 grgsggasrs ssmfrqyrgd pieivhkvsf kdavfgsknv qlrfsaldpc stcsgtgmkp 241 nthkvscstc hgtgttvhir ggfqmmstcp tcngegtmkr pqdnctkchg egvqvnrakt 301 itvdlphglq dgdvvripgq gsypdiavea dlkdsvklsr gdilvrirvd kdpnfsiknk 361 ydiwydkeip ittaalggtv tiptvegqki rikvapgtqy nqvisipnmg vpktstirgd 421 mkvqykivvk kpqslaekcl wealadvtnd dmakktmqpg taagtainee ilkkqkqeee 481 khakkdddnt lkrlenfitn tfrkikgdkk n // LOCUS NP_001335773 164 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFL015C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335773 VERSION NP_001335773.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348832.1 REFERENCE 1 (residues 1 to 164) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 164) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 164) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 164) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80293. Method: conceptual translation. FEATURES Location/Qualifiers source 1..164 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..164 /product="uncharacterized protein" /calculated_mol_wt="19170" CDS 1..164 /locus_tag="YFL015C" /coded_by="NM_001348832.1:1..495" /note="hypothetical protein; conserved across S. cerevisiae strains; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene" /db_xref="GeneID:850531" /db_xref="SGD:S000001879" ORIGIN 1 mlaytfpsfn fyvngffsfl flflflfpsl lrfyvilcrp lqvatyplnr cqqysslaif 61 tasgfwllvl vprakgpstr rhcyrqlapt hhrpffsifg wavsgirplp eiftwicasp 121 fflhsltppt fshfsvyqee kkekrrtpkn teqegnrmci wmsg // LOCUS NP_116640 109 aa linear PLN 30-JUN-2025 DEFINITION lipid-binding protein HSP12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116640 VERSION NP_116640.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179952.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 109) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12425. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..109 /product="lipid-binding protein HSP12" /calculated_mol_wt="11562" Region 1..59 /region_name="HSP9_HSP12" /note="Heat shock protein 9/12; pfam04119" /db_xref="CDD:427724" CDS 1..109 /gene="HSP12" /locus_tag="YFL014W" /gene_synonym="GLP1; HOR5" /coded_by="NM_001179952.1:1..330" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:20797624]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:20797624]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:10675505|PMID:20797624]" /experiment="EXISTENCE:direct assay:GO:0007155 cell adhesion [PMID:11816034]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20797624]" /experiment="EXISTENCE:mutant phenotype:GO:0007009 plasma membrane organization [PMID:20797624]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:20797624]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20797624]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:20797624]" /note="Plasma membrane protein involved in maintaining membrane organization; involved in maintaining organization during stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; protein abundance increased in response to DNA replication stress and dietary restriction; regulated by the HOG and Ras-Pka pathways; required for dietary restriction-induced lifespan extension" /db_xref="GeneID:850532" /db_xref="SGD:S000001880" ORIGIN 1 msdagrkgfg ekasealkpd sqksyaeqgk eyitdkadkv agkvqpednk gvfqgvhdsa 61 ekgkdnaegq gesladqard ymgaakskln daveyvsgrv hgeedptkk // LOCUS NP_116641 692 aa linear PLN 30-JUN-2025 DEFINITION Ies1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116641 VERSION NP_116641.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179953.1 REFERENCE 1 (residues 1 to 692) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 692) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 692) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 692) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12426. Method: conceptual translation. FEATURES Location/Qualifiers source 1..692 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..692 /product="Ies1p" /calculated_mol_wt="78622" CDS 1..692 /gene="IES1" /locus_tag="YFL013C" /coded_by="NM_001179953.1:1..2079" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12887900]" /experiment="EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:12887900]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Subunit of the INO80 chromatin remodeling complex; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:850534" /db_xref="SGD:S000001881" ORIGIN 1 mgkrvydpih dtfqlredns detkadspmq svksgsqeea spssiqsete tvttksipvi 61 heieiddknd ddstqseeen tnillnfeps tvpeatgast atgpvttntv rrkpkesnas 121 kynrhlkkpd gepfnrkdiq fsfmqellmd krqiftnvlk plyknsivpi nidgdklsin 181 vtdkeydart fvfndkltfa qlyvltiats ikcskilrdk llldqqvafs tcvlallvni 241 grlnttinfy lemtsqlrtf hsvpvlqlha ndpkllqdtp rlksilknlp wgneqlslme 301 tykkvdqndg evdtvnkfni inmlfsicdn sglidkrfls kyveveskaq eqdmvdeqne 361 vketeaenek qeskaayatt lfdildysky epkdrsnili wllyihletn lsqeeveesv 421 rffngledga pagkfilrct ersydtdped elefganqri krrefmskme egrkrertnv 481 tevkkpsigg dkseedgege ddkseetvee trslltptpi lessspmtln rkkvtpqlpk 541 vtpaaptete eeitsaaiid kndlnltplk kynssatvnk vdklisldln khvsengktq 601 eefladlkks qvpnrlkrrd iglikifnef edipvasvlg irgkkrkkfk dnllgfetdf 661 mknlgaskkv llnkieraei ddeeatamfk le // LOCUS NP_116643 148 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFL012W [Saccharomyces cerevisiae S288C]. ACCESSION NP_116643 VERSION NP_116643.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179954.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 148) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12427. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..148 /product="uncharacterized protein" /calculated_mol_wt="17048" CDS 1..148 /locus_tag="YFL012W" /coded_by="NM_001179954.1:1..447" /note="hypothetical protein; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin" /db_xref="GeneID:850535" /db_xref="SGD:S000001882" ORIGIN 1 mpksrpkrti assssvfygs spfqndgyik vmelvshivi einhsptatt detrkqnnpe 61 lkvkepvcnl kkwenntnfi ledhtknktk lsstdrirkw frrhilkeei eilshgkqls 121 sidedycpsn vlvgcsrdln klrsfqnf // LOCUS NP_116644 546 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116644 VERSION NP_116644.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179955.1 REFERENCE 1 (residues 1 to 546) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 546) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 546) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 546) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12428. Method: conceptual translation. FEATURES Location/Qualifiers source 1..546 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..546 /product="hexose transporter HXT10" /calculated_mol_wt="60531" Region 52..512 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(63,67,193,196..197,200,319..320,324..325,328..329, 354,424..425,428..429,433,456..457,460) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..546 /gene="HXT10" /locus_tag="YFL011W" /coded_by="NM_001179955.1:1..1641" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0005354 galactose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="Hexose transporter; expressed at low levels and expression is repressed by glucose" /db_xref="GeneID:850536" /db_xref="SGD:S000001883" ORIGIN 1 mvsssvsilg tsakastsls rkdeikltpe treasldipy kpiiaywtvm glclmiafgg 61 fifgwdtgti sgfinqtdfk rrfgelqrdg sfqlsdvrtg livgifnigc alggltlgrl 121 gdiygrkigl mcvilvyvvg iviqiassdk wyqyfigriv sgmgvggvav lsptliseis 181 pkhlrgtcvs fyqlmitlgi flgyctnygt kkysnsiqwr vplglcfawa ifmvigmvmv 241 pesprylvek gkyeearrsl aksnkvtvtd pgvvfefdti vanmelerav gnaswhelfs 301 nkgailprvi mgiviqslqq ltgcnyffyy gttifnavgm qdsfetsivl gavnfastfv 361 alyivdkfgr rkcllwgsas maicfvifat vgvtrlwpqg kdqpssqsag nvmivftcff 421 ifsfaitwap iayvivaety plrvknrama iavganwmwg fligfftpfi trsigfsygy 481 vfmgclifsy fyvfffvcet kgltleevne myeerikpwk sggwipssrr tpqptsstpl 541 vivdsk // LOCUS NP_116645 94 aa linear PLN 30-JUN-2025 DEFINITION Aua1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116645 VERSION NP_116645.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180024.1 REFERENCE 1 (residues 1 to 94) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 94) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 94) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 94) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12429. Method: conceptual translation. FEATURES Location/Qualifiers source 1..94 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..94 /product="Aua1p" /calculated_mol_wt="11591" CDS 1..94 /gene="AUA1" /locus_tag="YFL010W-A" /gene_synonym="YFL011W-A" /coded_by="NM_001180024.1:1..285" /experiment="EXISTENCE:mutant phenotype:GO:0006865 amino acid transport [PMID:8497191]" /note="Protein required for the negative regulation by ammonia of Gap1p; Gap1p is a general amino acid permease" /db_xref="GeneID:850537" /db_xref="SGD:S000001955" ORIGIN 1 mdrslqvyic mypyldgskq yrfdelisfy rpcpksldni kshyrqihhq irrrthqhhq 61 irrrthqhhh rsncsrqrqc lvrhscgrqm rvla // LOCUS NP_570898 211 aa linear PLN 30-JUN-2025 DEFINITION Wwm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_570898 VERSION NP_570898.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179956.1 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 211) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12430. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..211 /product="Wwm1p" /calculated_mol_wt="22524" Region 12..41 /region_name="WW" /note="WW domain; pfam00397" /db_xref="CDD:459800" CDS 1..211 /gene="WWM1" /locus_tag="YFL010C" /coded_by="NM_001179956.1:1..636" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:12062425]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="WW domain containing hypothetical protein; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1" /db_xref="GeneID:850538" /db_xref="SGD:S000001884" ORIGIN 1 maqsksnppq vpsgwkavfd deyqtwyyvd lstnssqwep prgttwprpk gpppgvnnek 61 ssrqqadqap ppyssqstpq vqagaqaqqp ryyqpqqpqy pqypqqqryy pqqapmpaaa 121 pqqayygtap stskgsghgg ammggllgvg agllggamle hafddhnydg pdtvvvenny 181 ygddaggsdg gfddaggfdg gfddgfdgsd f // LOCUS NP_116585 779 aa linear PLN 30-JUN-2025 DEFINITION SCF ubiquitin ligase complex subunit CDC4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116585 VERSION NP_116585.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179957.1 REFERENCE 1 (residues 1 to 779) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 779) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 779) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 779) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12431. Method: conceptual translation. FEATURES Location/Qualifiers source 1..779 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..779 /product="SCF ubiquitin ligase complex subunit CDC4" /calculated_mol_wt="85959" Region 228..272 /region_name="CDC4_D" /note="Cell division control protein 4 dimerization domain; pfam16856" /db_xref="CDD:407099" Region 275..322 /region_name="F-box_ScCDC4-like" /note="F-box domain found in Saccharomyces cerevisiae cell division control protein 4 (ScCDC4) and similar proteins; cd22141" /db_xref="CDD:438913" Site order(275,277..278,282,285..286,289..291,294,297..303,305) /site_type="other" /note="Skp1 binding site [polypeptide binding]" /db_xref="CDD:438913" Region 374..693 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(380,397,401,407..408,420..421,438,442,448..449, 461..462,481,486,492..493,529,544,549,555..556,568..569, 587,591,597..598,630..631,646,651,657..658,670,688,692) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 385..420 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 426..461 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 466..527 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 534..567 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 573..629 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 637..667 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 716..751 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..779 /gene="CDC4" /locus_tag="YFL009W" /coded_by="NM_001179957.1:1..2340" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:9346239]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9346239|PMID:9346238]" /experiment="EXISTENCE:direct assay:GO:0016363 nuclear matrix [PMID:2244914]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:23645675]" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:9346239|PMID:9346238]" /experiment="EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:9346239|PMID:9346238]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:direct assay:GO:0043224 nuclear SCF ubiquitin ligase complex [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0050815 phosphoserine residue binding [PMID:23314252]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:9346238]" /experiment="EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:7954792]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10409741]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10409741]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:328339]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:21098119]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:9346239|PMID:9346238]" /note="F-box protein required for both the G1/S and G2/M phase transitions; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCFCdc4 complex; SCFCdc4 acts as a ubiquitin-protein ligase directing ubiquitination of cyclin-dependent kinase (CDK) phosphorylated substrates, such as: Sic1p, Far1p, Cdc6p, Clb6p, and Cln3p" /db_xref="GeneID:850539" /db_xref="SGD:S000001885" ORIGIN 1 mgsfplaefp lrdipvpysy rvsggiassg svtalvtaag thrnsstakt vetedgeedi 61 deyqrkraag sgestpersd fkrvkhdnhk tlhpvnlqnt gaasvdndgl hnltdisnda 121 ekllmsvddg saapstlsvn mgvashnvaa pttvnaatit gsdvsnnvns atinnpmeeg 181 alplsptass pgtttplakt tktinnnnni adlieskdsi ispeylsdei fsainnnlph 241 ayfknllfrl vanmdrsels dlgtlikdnl krdlitslpf eislkifnyl qfediinslg 301 vsqnwnkiir kstslwkkll isenfvspkg fnslnlklsq kypklsqqdr lrlsflenif 361 ilknwynpkf vpqrttlrgh mtsvitclqf ednyvitgad dkmirvydsi nkkfllqlsg 421 hdggvwalky ahggilvsgs tdrtvrvwdi kkgccthvfk ghnstvrcld iveyknikyi 481 vtgsrdntlh vwklpkessv pdhgeehdyp lvfhtpeenp yfvgvlrghm asvrtvsghg 541 nivvsgsydn tlivwdvaqm kclyilsght driystiydh erkrcisasm dttiriwdle 601 niwnngecsy atnsaspcak ilgamytlqg htalvgllrl sdkflvsaaa dgsirgwdan 661 dysrkfsyhh tnlsaittfy vsdnilvsgs enqfniynlr sgklvhanil kdadqiwsvn 721 fkgktlvaav ekdgqsflei ldfskaskin yvsnpvnsss sslesistsl gltrttiip // LOCUS NP_116647 1225 aa linear PLN 30-JUN-2025 DEFINITION cohesin subunit SMC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116647 VERSION NP_116647.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179958.1 REFERENCE 1 (residues 1 to 1225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1225) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 1225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12432. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..1225 /product="cohesin subunit SMC1" /calculated_mol_wt="141150" Region 4..1209 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; pfam02463" /db_xref="CDD:426784" CDS 1..1225 /gene="SMC1" /locus_tag="YFL008W" /gene_synonym="CHL10" /coded_by="NM_001179958.1:1..3678" /experiment="EXISTENCE:direct assay:GO:0000217 DNA secondary structure binding [PMID:9727028]" /experiment="EXISTENCE:direct assay:GO:0003680 minor groove of adenine-thymine-rich DNA binding [PMID:9727028]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:9727028]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030892 mitotic cohesin complex [PMID:9990856]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:9335333]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:8276886]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:11448778|PMID:15280507]" /note="Subunit of the multiprotein cohesin complex; essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure" /db_xref="GeneID:850540" /db_xref="SGD:S000001886" ORIGIN 1 mgrlvglels nfksyrgvtk vgfgesnfts iigpngsgks nmmdaisfvl gvrsnhlrsn 61 ilkdliyrgv lndensddyd negaassnpq sayvkafyqk gnklvelmri isrngdtsyk 121 idgktvsykd ysifleneni likaknflvf qgdveqiaaq spvelsrmfe evsgsiqykk 181 eyeelkekie klsksatesi knrrrihgel ktykeginkn eeyrkqldkk nelqkfqalw 241 qlyhleqqke eltdklsaln seisslkgki nnemkslqrs kssfvkesav iskqkskldy 301 ifkdkeklvs dlrlikvpqq aagkrishie krieslqkdl qrqktyverf etqlkvvtrs 361 keafeeeikq sarnydkfkl nendlktync lhekyltegg sileekiavl nndkreiqee 421 lerfnkradi skrriteels itgekldtql ndlrvslnek nalhterlhe lkklqsdies 481 annqeydlnf klretlvkid dlsanqretm kerklrenia mlkrffpgvk glvhdlchpk 541 kekyglavst ilgknfdsvi venltvaqec iaflkkqrag tasfipldti etelptlslp 601 dsqdyilsin aidyepeyek amqyvcgdsi icntlniakd lkwkkgirgk lvtiegalih 661 kaglmtggis gdannrwdke eyqslmslkd klliqidels ngqrsnsira revensvsll 721 nsdianlrtq vtqqkrslde nrleikyhnd liekeiqpki telkkklddl entkdnlvke 781 kealqnnifk eftskigfti keyenhsgel mrqqskelqq lqkqiltven klqfetdrls 841 ttqrryekaq kdlenaqvem ksleeqeyai emkigsiesk leehknhlde lqkkfvtkqs 901 elnssedile dmnsnlqvlk rerdgikedi ekfdlervta lknckisnin ipissettid 961 dlpisstdne aitisnsidi nykglpkkyk enntdsarke leqkihevee ilnelqpnar 1021 alerydeaeg rfevinnete qlkaeekkil nqflkikkkr kelfektfdy vsdhldaiyr 1081 eltknpnsnv elaggnaslt iededepfna gikyhatppl krfkdmeyls ggektvaala 1141 llfainsyqp spffvldevd aalditnvqr iaayirrhrn pdlqfivisl kntmfeksda 1201 lvgvyrqqqe nsskiitldl snyae // LOCUS NP_116648 2143 aa linear PLN 30-JUN-2025 DEFINITION proteasome activator BLM10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116648 VERSION NP_116648.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179959.1 REFERENCE 1 (residues 1 to 2143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2143) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 2143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 2143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12433. On Oct 2, 2003 this sequence version replaced NP_116648.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..2143 /product="proteasome activator BLM10" /calculated_mol_wt="245866" Region 79..159 /region_name="BLM10_N" /note="Proteasome-substrate-size regulator, N-terminal; pfam16547" /db_xref="CDD:435417" Region 511..1030 /region_name="BLM10_mid" /note="Proteasome-substrate-size regulator, mid region; pfam16507" /db_xref="CDD:465150" Region 2056..2142 /region_name="DUF3437" /note="Domain of unknown function (DUF3437); pfam11919" /db_xref="CDD:463397" CDS 1..2143 /gene="BLM10" /locus_tag="YFL007W" /gene_synonym="YFL006W" /coded_by="NM_001179959.1:1..6432" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22908043|PMID:12973301|PMID:15778719]" /experiment="EXISTENCE:direct assay:GO:0016504 peptidase activator activity [PMID:22025621]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:23982732]" /experiment="EXISTENCE:direct assay:GO:0061136 regulation of proteasomal protein catabolic process [PMID:22025621]" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:22025621]" /experiment="EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:17911101]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:12973301]" /experiment="EXISTENCE:mutant phenotype:GO:0070628 proteasome binding [PMID:22025621]" /experiment="EXISTENCE:mutant phenotype:GO:1902906 proteasome storage granule assembly [PMID:23982732]" /experiment="EXISTENCE:mutant phenotype:GO:1990236 proteasome core complex import into nucleus [PMID:23982732]" /note="Proteasome activator; binds the core proteasome (CP) and stimulates proteasome-mediated protein degradation by inducing gate opening; required for sequestering CP into proteasome storage granule (PSG) during quiescent phase and for nuclear import of CP in proliferating cells; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200" /db_xref="GeneID:850541" /db_xref="SGD:S000001887" ORIGIN 1 mtanndddik spipitnktl sqlkrfersp grpsssqgei krkksrlyaa dgrphsplra 61 rsatptlqdq klfngmdsts llnerlqhyt ldyvsdraqh mkniydpssr wfsrsvrpef 121 pieeflpykt eshedqakyl chvlvnlyia issldiqgli sisskdladl kkevddlalk 181 tdlfrlsnnt aendllgndi adyddaegle deldeyfdla gpdfnatgki taksativnv 241 nhwtnelknc lhfdfpvalr kslatvyyyl slvqgqkvyr qmhvdmferl vsldddrtnf 301 tellqkqgll ldhqimlnfl ceflpypdpd yaryelsske dlqlfrlllk hahnakpffd 361 kskesllvdt mnfllsslap stmmavmpiv tsvvpyhyhi hskiidyfpf cysiwssvsa 421 nvaidthmyd fvgsiskdvh nkilssehek dvvgvefgef giftddqmtf mfnrlqghlr 481 tdgqihsysr tvkpfvyain gskkdrffek lvslakaiet fihpsnngfw tkpnakfvha 541 fiksyhgrvk yeedicargv tngicltsfc heeiveifln iislgsqnkn pdianyyisc 601 faylleldps nayliydkil idlydtladq finsrhriis slkqftrvir fivmdklyrv 661 hitnvlsmlv skldmndtnl tsnlingivs iaafipiqdl tgeddyisfe sdtlplvqqh 721 fyhikcgess ktfrvddell nnafkasttv fqsmlkvyve kifqlvdvdl edslvtkinq 781 ttmilqesmd dkifnyfasl lqrnfwsnds fkekdpnyel vtiplaalvr rnnglskelv 841 rtllfhikeq ikrgagsvrs tseiqqrdvk lvlyltalnd vlrqchesll eysdelitfm 901 kylydnvtnp pldvitsivi hsalatlctt eitdcrlfpe dskipekdrw gglqfdprrf 961 dkqhlsfqwh vpssdeitls isileslsey cinnveelmk aprhdseygd miqkyvlvmt 1021 htlsgssllf dpdfnkyrtq snlsyrekli llknirennc dpqeldidie qirsgkdded 1081 yieskdieag lnagvsdvvq lrdefpdeli vdeevvsemp sgvntpiagt hgtdnsamss 1141 dlafrdldiy tcnyyfgntt eeklqnpqyl qvhrvrarig hffhklyvfl stnfenntnm 1201 fqillhglkv wftdlgqetv fnedpnafid vdflenvqsl shvnepftrt nfairanslh 1261 qsrvllhstn rkasklenll lvdiiqlats lypdiykpaq gtlvhcmkql vgsygvvink 1321 iipslekaik dhdymkiqvi lnvllikkih rklmtdykdi grliflliec crvneleigm 1381 yadkiltdiv igikipssvc visdqaflpl appdgtinlq veavklakkk kreyylsllv 1441 dlqdklldkl dnekdmgwki rmfilrfvtq iqsnleskpd kravfsiisq istkhpeiih 1501 lvvksllstc nkiislsdye yditraykne fnpsfveild tsttsfpktf teemnnfdnp 1561 kyfidlrayv gwlcwgrlmy vmspkalkln lrenelevlk taghlltref lrdvtmnlvq 1621 dnetrgvfss gnvsffslvi llissgfcel nmsdlfelce syynkddkas mimsveivag 1681 lvcgskfmsv sdldkrdtfi enflakcldy elnhdafeiw stlawwlpav vdlrrsktff 1741 chfinadgmf dresdaathq tskiymlrsi lmsmefrapd vgklfdelvf dhpydqvrqa 1801 vakllttlvq nqsnpsisdp ttlleaernd pdglglplks vpekvdayik kqfeiiknle 1861 dsvvglnpqq fiktdyfyrt stifywikem argpnkvllv pylvdyvlpf liglvkhkdv 1921 calasldpvr lyaglgympi rknhvaaivd yvcssnvals snqtklqlaf iqhflsaell 1981 qlteeeknki lefvvsnlyn eqfvevrvra asilsdivhn wkeeqpllsl ierfakgldv 2041 nkytskerqk lsktdikihg nvlglgaiis afpyvfplpp wipkqlsnls swartsgmtg 2101 qaakntisef kkvradtwkf drasfnteel edlegvlwrs yya // LOCUS NP_116650 215 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase SEC4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116650 VERSION NP_116650.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179961.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 215) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12434. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..215 /product="Rab family GTPase SEC4" /calculated_mol_wt="23375" Region 18..183 /region_name="Rab8_Rab10_Rab13_like" /note="Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13); cd01867" /db_xref="CDD:206659" Site 18..22 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206659" Site 27..34 /site_type="other" /note="G1 box" /db_xref="CDD:206659" Site order(29..35,45..48,51..52,78,133..134,136..137,163..164) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206659" Site order(35..47,49..51) /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206659" Site order(45,50..58) /site_type="other" /note="Switch I region" /db_xref="CDD:206659" Site order(48,50,54..61,68,70) /site_type="other" /note="GEF interaction site [polypeptide binding]" /db_xref="CDD:206659" Site 52 /site_type="other" /note="G2 box" /db_xref="CDD:206659" Site order(53,55..57,72,74,81..82,85,89,91..94,180) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206659" Site order(53..54,56,74..75,82,84,86..88) /site_type="other" /note="putative GDI interaction site [polypeptide binding]" /db_xref="CDD:206659" Site 53..57 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206659" Site 70..74 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206659" Site 75..78 /site_type="other" /note="G3 box" /db_xref="CDD:206659" Site order(78,80..90) /site_type="other" /note="Switch II region" /db_xref="CDD:206659" Site 81..86 /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206659" Site 89..93 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206659" Site 98..103 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206659" Site 121..130 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206659" Site 133..136 /site_type="other" /note="G4 box" /db_xref="CDD:206659" Site 162..164 /site_type="other" /note="G5 box" /db_xref="CDD:206659" Site 178..183 /site_type="other" /note="Rab subfamily motif 4 (RabSF4)" /db_xref="CDD:206659" CDS 1..215 /gene="SEC4" /locus_tag="YFL005W" /gene_synonym="SRO6" /coded_by="NM_001179961.1:1..648" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9128251]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:2111819]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:2111819]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006887 exocytosis [PMID:15772160]" /experiment="EXISTENCE:direct assay:GO:0030133 transport vesicle [PMID:23079598]" /experiment="EXISTENCE:direct assay:GO:0031982 vesicle [PMID:12456647]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:22832273]" /experiment="EXISTENCE:genetic interaction:GO:0006914 autophagy [PMID:20444978]" /experiment="EXISTENCE:genetic interaction:GO:0007107 membrane addition at site of cytokinesis [PMID:12456647]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:9017592]" /experiment="EXISTENCE:mutant phenotype:GO:0006906 vesicle fusion [PMID:9017592]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:20444978]" /experiment="EXISTENCE:mutant phenotype:GO:0007107 membrane addition at site of cytokinesis [PMID:12456647]" /experiment="EXISTENCE:mutant phenotype:GO:0031321 ascospore-type prospore assembly [PMID:9425151]" /note="Rab family GTPase; essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; exocyst association is negatively regulated via phosphorylation by Cdc5p during cytokinesis" /db_xref="GeneID:850543" /db_xref="SGD:S000001889" ORIGIN 1 msglrtvsas sgngksydsi mkilligdsg vgkscllvrf vedkfnpsfi ttigidfkik 61 tvdingkkvk lqlwdtagqe rfrtittayy rgamgiilvy dvtdertftn ikqwfktvne 121 handeaqlll vgnksdmetr vvtadqgeal akelgipfie ssaknddnvn eifftlakli 181 qekidsnklv gvgngkegni sinsgsgnss ksncc // LOCUS NP_116651 828 aa linear PLN 30-JUN-2025 DEFINITION vacuolar transporter chaperone [Saccharomyces cerevisiae S288C]. ACCESSION NP_116651 VERSION NP_116651.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179962.1 REFERENCE 1 (residues 1 to 828) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 828) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 828) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 828) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 828) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 828) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 828) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 828) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12435. Method: conceptual translation. FEATURES Location/Qualifiers source 1..828 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..828 /product="vacuolar transporter chaperone" /calculated_mol_wt="95310" Region 2..134 /region_name="SPX_VTC2_like" /note="SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; cd14480" /db_xref="CDD:269901" Region 197..547 /region_name="PolyPPase_VTC2-3_like" /note="Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, and -3, and similar proteins; cd07892" /db_xref="CDD:143630" Site order(203,205,207) /site_type="active" /note="signature motif [active]" /db_xref="CDD:143630" Site order(204,296,299,506,510) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:143630" Site order(207,282,294,297,305,307,323,325,336,338,404,406,418, 475,477,520..523) /site_type="active" /note="polyP binding site [active]" /db_xref="CDD:143630" Site order(207,282,305,307,323,338,404,406,422,475,477,520..523) /site_type="active" /db_xref="CDD:143630" Site order(207,282,305,307,323,338,404,406,422,475,520..522) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:143630" Site order(282,305,323,521..523) /site_type="active" /note="acceptor-phosphate pocket [active]" /db_xref="CDD:143630" Site order(475,477) /site_type="other" /note="putative metal binding residues [ion binding]" /db_xref="CDD:143630" Region 662..791 /region_name="VTC1" /note="Vacuolar transporter chaperone [Posttranslational modification, protein turnover, chaperones]; COG5264" /db_xref="CDD:227589" CDS 1..828 /gene="VTC2" /locus_tag="YFL004W" /gene_synonym="PHM1" /coded_by="NM_001179962.1:1..2487" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:11823419]" /experiment="EXISTENCE:direct assay:GO:0005516 calmodulin binding [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:genetic interaction:GO:0006797 polyphosphate metabolic process [PMID:11102525]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:11102525]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:10480897]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:11823419]" /experiment="EXISTENCE:physical interaction:GO:0033254 vacuolar transporter chaperone complex [PMID:11823419]" /note="Regulatory subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; targeted to vacuole via AP-3 pathway; VTC2 has a paralog, VTC3, that arose from the whole genome duplication" /db_xref="GeneID:850544" /db_xref="SGD:S000001890" ORIGIN 1 mlfgvklane vyppwkgsyi nyeglkkflk edsvkdgsnd kkarwddsde skfveeldke 61 lekvygfqlk kynnlmerls hlekqtdtea aikaldadaf qrvleellse steldnfkrl 121 nftgfakivk khdklypkyp svksllevrl kelpshseey spllyrisfl ynilrsnfnt 181 aseplasask fssivsndid mnfrsfkfwv hndnlmevkt rilrhlpvlv yanvpsendd 241 lvnrfesdis nndeivgsss stssvehglg arsfdplint lyfdnehfel yndkllklns 301 aptlrlrwtg qlsdkpdifl ekktliedea tgksefdltk lqlkqkfing fifegdkkfk 361 eqtlkklkes gtagrdlerl eedfseiqnf iiknelqpvf rtvytrtafq ipgddkirvt 421 idsnivfike dsfdrerpir dpntwhrtdi danvanplkf lrggeyakfp ysvmeikvks 481 sldssmsass misnvklpkk hgqwlndltn shlvkeipkf sifvqgvasl ygddekldil 541 pfwlpdletd irqdpkqaye eekkkllkqk eiqkkidgmr rlsnlkepqh qaavpvsqee 601 neritsqgdl eadgssdeet eqephskrsk kvrrrkpkat flrilagrdp klmgvdseee 661 eielppgvkk plnllknagp vnveakvwla nertfnrwls vtsllsvltf siynsvkkae 721 yptlanymay vyfgltifca lwsysiymkr vdiiqqrsgq hldaplgpvl vsivlfvtlv 781 vnfvmafrna aksrqelqiq nlevperipe vlrplqnylf klmgpssd // LOCUS NP_116652 878 aa linear PLN 30-JUN-2025 DEFINITION MutS family protein MSH4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116652 VERSION NP_116652.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179963.1 REFERENCE 1 (residues 1 to 878) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 878) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 878) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 878) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 878) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 878) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 878) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 878) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12436. Method: conceptual translation. FEATURES Location/Qualifiers source 1..878 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..878 /product="MutS family protein MSH4" /calculated_mol_wt="99095" Region 93..773 /region_name="MutS" /note="DNA mismatch repair ATPase MutS [Replication, recombination and repair]; COG0249" /db_xref="CDD:440019" Region 599..801 /region_name="ABC_MSH4_euk" /note="ATP-binding cassette domain of eukaryotic MutS4 homolog; cd03282" /db_xref="CDD:213249" Site 634..641 /site_type="other" /note="Walker A/P-loop" /db_xref="CDD:213249" Site order(637..638,640..642,678,712..713,746) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:213249" Site 675..678 /site_type="other" /note="Q-loop/lid" /db_xref="CDD:213249" Site 682..695 /site_type="other" /note="ABC transporter signature motif" /db_xref="CDD:213249" Site 708..713 /site_type="other" /note="Walker B" /db_xref="CDD:213249" Site 716..719 /site_type="other" /note="D-loop" /db_xref="CDD:213249" Site 742..748 /site_type="other" /note="H-loop/switch region" /db_xref="CDD:213249" CDS 1..878 /gene="MSH4" /locus_tag="YFL003C" /coded_by="NM_001179963.1:1..2637" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11454751]" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:30467025]" /experiment="EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:30467025]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:30467025]" /experiment="EXISTENCE:direct assay:GO:0062037 D-loop DNA binding [PMID:30467025]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:7622037|PMID:18615017|PMID:11454751]" /experiment="EXISTENCE:physical interaction:GO:0062128 MutSgamma complex [PMID:9374523]" /note="Protein involved in meiotic recombination; required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein" /db_xref="GeneID:850545" /db_xref="SGD:S000001891" ORIGIN 1 msesnlssfi stnyfnlrsa anssnsiskp stkksirnqk sptnisswal kkktlqiaet 61 twennekdst hshylmtgsm asrtatslsr ystnasllgp sidcvlcciy evprdistri 121 glciincntg qmylsdfmds qiyirvvhkl qiyqpteili pssslaptvs klatmikfnv 181 aetvkieegs rkcfnsqdgl aaitkylmdd tkkdlkieei idktfalcaa saaisymeei 241 iskssrnlna frklriqfeg tentmlidsk tvrglelven kldkngislw kfldttstkm 301 gqrslrnsil qpltdrgsie mrlealeelk anddllqklr lemkslpdld klfsrllcin 361 hsaikpdqri nyvlllketl qsvkslkdal ndqliqsrli setkkifnnd aimeieklin 421 scinedcvwa ssaiqllnqr syavksdsng lldvsrqiyk evkeeffrev edltaknkin 481 ldhnydsarg fylrikrqef tddvatlpdv fisrtikkny iecttlniik knarlkevme 541 eilllseetv delldkiath iselfmiaea vaildlvcsf tynlkennyt ipiftnnlli 601 rdsrhpllek vlknfvpnti sstkhssslq iitgcnmsgk svylkqvali cimaqmgsgi 661 palygsfpvf krlharvcnd smeltssnfg femkemayfl ddintetlli ldelgrgssi 721 adgfcvslav tehllrteat vflsthfqdi pkimskkpav shlhmdavll ndnsvkmnyq 781 ltqksvaien sgirvvkkif npdiiaeayn ihsllkiaka rtenedsngv vdqktinqmk 841 rihnlvailk ecagnekepl tlgklkeins dfienfee // LOCUS NP_058157 438 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058157 VERSION NP_058157.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184430.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 438) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12438. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..438 /product="gag protein" /calculated_mol_wt="49631" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..438 /locus_tag="YFL002W-B" /coded_by="NM_001184430.1:1..1317" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:850547" /db_xref="SGD:S000007404" ORIGIN 1 mesqqlhqnp hslhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqnq hsevpqaetk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeiksqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lrpateri // LOCUS NP_116653 1770 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_116653 VERSION NP_116653.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180862.2 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1770) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12437. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..1770 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="201909" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 574..641 /region_name="gag_pre-integrs" /note="GAG-pre-integrase domain; pfam13976" /db_xref="CDD:372857" Region 660..761 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1285..>1468 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1621..1757 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1625..1628,1662..1664,1667,1700,1727,1754) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1770 /locus_tag="YFL002W-A" /coded_by="join(NM_001180862.2:1..1293, NM_001180862.2:1295..5314)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:850548" /db_xref="SGD:S000002962" ORIGIN 1 mesqqlhqnp hslhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqnq hsevpqaetk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeiksqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lgqqqkeskp thtidsndel pdhllidsga sqtlvrsahy lhhatpnsei 481 nivdaqkqdi pinaignlhf nfqngtktsi kalhtpniay dllslselan qnitacftrn 541 tlersdgtvl apivkhgdfy wlskkylips hiskltinnv nksksvnkyp yplihrmlgh 601 anfrsiqksl kknavtylke sdiewsnast yqcpdcligk stkhrhvkgs rlkyqesyep 661 fqylhtdifg pvhhlpksap syfisftdek trfqwvyplh drreesilnv ftsilafikn 721 qfnarvlviq mdrgseytnk tlhkfftnrg itacytttad srahgvaerl nrtllndcrt 781 llhcsglpnh lwfsavefst iirnslvspk ndksarqhag lagldittil pfgqpvivnn 841 hnpdskihpr gipgyalhps rnsygyiiyl pslkktvdtt nyvilqdkqs kldqfnydtl 901 tfdddlnrlt ahnqsfieqn eteqsydqnt esdhdyqsei einsdplvnd fssqsinplq 961 ldkepvqkvr apkevdadis eynilpstir srtphiinke stemggtves dttsprhsst 1021 ftarnqnrpg stnemidlts qdrvnyglen ikttrlggte epyiqrnsdt nikyrttnst 1081 psiddrssns esttpiisie tkavcdntps idtdppeyrs sdhatpnimp dkssknvtad 1141 silddlplpd lthksptdts dvskdiphih srqtnsslgg mddsnvlttt kskkrsledn 1201 eteievsrdt wnnknmrsle pprskkrinl iaaikgvksi kpvrttlryd eaitynkdnk 1261 ekdryveayh keisqllkmn twdtnkyydr ndidpkkvin smfifnkkrd gthkarfvar 1321 gdiqhpdtyd sdmqsntvhh yalmtslsia ldndyyitql dissaylyad ikeelyirpp 1381 phlglndkll rlrkslyglk qsganwyeti ksylinccdm qevrgwscvf knsqvticlf 1441 vddmilfskd lnankkiitt lkkqydtkii nlgesdneiq ydilgleiky qrskymklgm 1501 ekslteklpk lnvplnpkgk klrapgqpgh yidqdeleid edeykekvhe mqkliglasy 1561 vgykfrfdll yyintlaqhi lfpsrqvldm tyeliqfmwd trdkqliwhk nkptkpdnkl 1621 vaisdasygn qpyyksqign ifllngkvig gkstkasltc tstteaeiha vseaipllnn 1681 lshlvqelnk kpiikglltd srstisiiks tneekfrnrf fgtkamrlrd evsgnnlyvy 1741 yietkkniad vmtkplpikt fklltnkwih // LOCUS NP_116654 606 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase SPB4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116654 VERSION NP_116654.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179964.1 REFERENCE 1 (residues 1 to 606) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 606) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 606) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 606) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12439. Method: conceptual translation. FEATURES Location/Qualifiers source 1..606 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..606 /product="ATP-dependent RNA helicase SPB4" /EC_number="3.6.4.13" /calculated_mol_wt="69291" Region 8..399 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" Region 409..466 /region_name="DUF4217" /note="Domain of unknown function (DUF4217); pfam13959" /db_xref="CDD:464056" CDS 1..606 /gene="SPB4" /locus_tag="YFL002C" /coded_by="NM_001179964.1:1..1821" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:9769101]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:9769101]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:21825077]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:22735702]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:2408148|PMID:21825077]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:2408148]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]" /experiment="EXISTENCE:physical interaction:GO:0030686 90S preribosome [PMID:21825077]" /note="Putative ATP-dependent RNA helicase; nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients" /db_xref="GeneID:850549" /db_xref="SGD:S000001894" ORIGIN 1 mskslewdnl gfsllpwirt gldvmgfetm tpvqastipm lagnkdvvvd svtgsgktaa 61 fvipvlekvv keeantskfk kahfhsliia ptrelsrqie svvlsflehy psdlfpikcq 121 llvgtneatv rddvsnflrn rpqiligtpg rvldflqmpa vktsacsmvv mdeadrlldm 181 sfikdtekil rllpkqrrtg lfsatmrsag sdifktglrn pvritvnskn qapsslklny 241 cvvnpaeklq llvsilnnyk fkkcivyfpt cvsvsyfysf iqylgkrnil vneveifslh 301 gklqtsartk tltaftdsls nsvlfttdva argidipdvd lviqldpptn tdmfmhrcgr 361 tgranrvgka itflnegree dfipfmqvkn veleeldlev kgittnfyed frnwiledrd 421 rfdkgvkayv afikyysnhs atsifrlqsl dyvgiaklyg lfrlprmpei tkylatekqe 481 gifpgnwlvd ppvnmdeyky kdkkrekerq etlknislin dkkklkselk kknlawsdkt 541 ltkerklerk ekmslkrkai eeelkaeeld enaeeerike dwkeivlqnk rkkvsskaiq 601 gnfddl // LOCUS NP_116655 442 aa linear PLN 30-JUN-2025 DEFINITION pseudouridine synthase DEG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116655 VERSION NP_116655.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179965.1 REFERENCE 1 (residues 1 to 442) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 442) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 442) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 442) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12440. Method: conceptual translation. FEATURES Location/Qualifiers source 1..442 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..442 /product="pseudouridine synthase DEG1" /EC_number="5.4.99.45" /calculated_mol_wt="50758" Region 96..345 /region_name="PseudoU_synth_ScPus3" /note="Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like; cd02569" /db_xref="CDD:211336" Site order(148..151,296) /site_type="active" /note="probable active site [active]" /db_xref="CDD:211336" CDS 1..442 /gene="DEG1" /locus_tag="YFL001W" /gene_synonym="HRM3; PUS3" /coded_by="NM_001179965.1:1..1329" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9430663]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9430663]" /experiment="EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:9430663]" /experiment="EXISTENCE:direct assay:GO:0031119 tRNA pseudouridine synthesis [PMID:9430663]" /experiment="EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:9430663]" /experiment="EXISTENCE:mutant phenotype:GO:0031119 tRNA pseudouridine synthesis [PMID:9430663]" /experiment="EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25192136]" /note="tRNA:pseudouridine synthase; introduces pseudouridines at position 38 or 39 in tRNA; also responsible for pseudouracil modification of some mRNAs; important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability" /db_xref="GeneID:850550" /db_xref="SGD:S000001895" ORIGIN 1 msnfirrlvg kmkaistgtn aivskkdsiy anwskeqlir ritelenank phsekfqhie 61 dnkkrkisqe evtrskakka pkkfdfskhn trfialrfay lgwnynglav qkeytplptv 121 egtileamnk cklvpsmvlq dykfsrcgrt dkgvsamnqv islevrsnlt deeqrdptnd 181 sreipyvhvl nqllpddiri savclrpppn fdarfscvhr hykyifngkn lniekmskaa 241 syfvgerdfr nfckldgskq itnfkrtiis skilplsetf ycfdlvgsaf lwhqvrcmma 301 ilflvgqsle vpeivlrltd iektpqrpvy emandiplll ydckfpemdw qeptvddyka 361 ikfttateal tlhyelkaav cnifkdvlpt antnnfskti inlgdgrgkv vgtyvkledr 421 svmepvevvn akyskkknnk nk // LOCUS NP_116656 204 aa linear PLN 30-JUN-2025 DEFINITION Loc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116656 VERSION NP_116656.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179966.1 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 204) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12441. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..204 /product="Loc1p" /calculated_mol_wt="23459" CDS 1..204 /gene="LOC1" /locus_tag="YFR001W" /coded_by="NM_001179966.1:1..615" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11309412]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16871394]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:31323064]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:23212245|PMID:27458021|PMID:11583614]" /experiment="EXISTENCE:direct assay:GO:0033592 RNA strand annealing activity [PMID:39558160]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:39558160]" /experiment="EXISTENCE:direct assay:GO:0140691 RNA folding chaperone [PMID:39558160]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:16871394]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16871394]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16871394]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16871394]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:11309412]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614|PMID:27458021|PMID:31779129]" /experiment="EXISTENCE:mutant phenotype:GO:0101031 protein folding chaperone complex [PMID:31779129]" /experiment="EXISTENCE:physical interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]" /note="RNA binding chaperone with ATP-independent RNA annealing activity; Nucleolar protein involved in asymmetric localization of ASH1 mRNA; binds cooperatively with She2p to the E3 zip-code element in the 3'-UTR; ribosomal 60S biogenesis factor required for Rpl43p loading; 66S pre-ribosomal particle component involved in pre-rRNA processing and 60S nuclear export; Ty1 host factor; has intrinsically disordered RNA binding (PUN) motifs; relocalizes to the cytoplasm upon DNA replication stress" /db_xref="GeneID:850551" /db_xref="SGD:S000001897" ORIGIN 1 mapkkpskrq nlrrevapev fqdsqarnql anvphlteks aqrkpsktkv kkeqslarly 61 gakkdkkgky sekdlniptl nraivpgvki rrgkkgkkfi adndtltlnr littigdkyd 121 diaeskleka rrleeirelk rkeierkeal kqdkleekkd eikkkssvar tirrknkrdm 181 lkseakases ktegrkvkkv sfaq // LOCUS NP_116657 839 aa linear PLN 30-JUN-2025 DEFINITION linker nucleoporin NIC96 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116657 VERSION NP_116657.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179967.1 REFERENCE 1 (residues 1 to 839) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 839) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 839) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 839) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 839) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 839) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 839) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 839) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12442. Method: conceptual translation. FEATURES Location/Qualifiers source 1..839 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..839 /product="linker nucleoporin NIC96" /calculated_mol_wt="96043" Region 252..831 /region_name="Nic96" /note="Nup93/Nic96; pfam04097" /db_xref="CDD:461172" CDS 1..839 /gene="NIC96" /locus_tag="YFR002W" /coded_by="NM_001179967.1:1..2520" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:7688296|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0044612 nuclear pore linkers [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:9813081]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220|PMID:7828598]" /experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:8682854|PMID:11121302]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:18206968]" /note="Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)" /db_xref="GeneID:850552" /db_xref="SGD:S000001898" ORIGIN 1 mletlrgnkl hsgtskgank klnellessd nlpsasselg siqvsinelr rrvfqlrskn 61 kaskdytkah yllansglsf edvdafikdl qtnqflepnp pkiieseele fyirtkkeen 121 ilmsieqlln gatkdfdnfi nhnlnldwaq hknevmknfg iliqdkktvd hkksissldp 181 klpswgnkgn nilnsnesrl nvnennilre kfenyarivf qfnnsrqang nfdianefis 241 ilssangtrn aqlleswkil esmkskdini vevgkqyleq qflqytdnly kknmneglat 301 nvnkiksfid tklkkadksw kisnltving vpiwalifyl lraglikeal qvlvenkani 361 kkveqsflty fkayasskdh glpveystkl hteynqhiks sldgdpyrla vykligrcdl 421 srknipavtl siedwlwmhl mlikekdaen dpvyerysle dfqniiisyg psrfsnyylq 481 tlllsglygl aidytytfse mdavhlaigl aslklfkids strltkkpkr dirfanilan 541 ytksfrysdp rvaveylvli tlnegptdve lchealrelv letkeftvll gkigrdgari 601 pgvieerqpl lhvrdekefl htiteqaarr adedgriyds illyqlaeey divitlvnsl 661 lsdtlsasdl dqplvgpddn setnpvllar rmasiyfdna gisrqihvkn keicmlllni 721 ssirelyfnk qwqetlsqme lldllpfsde lsarkkaqdf snlddnivkn ipnlliitls 781 cisnmihiln eskyqsstkg qqidslknva rqcmiyagmi qyrmpretys tlinidvsl // LOCUS NP_116658 155 aa linear PLN 30-JUN-2025 DEFINITION type 1 protein phosphatase-activating protein YPI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116658 VERSION NP_116658.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179968.1 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 155) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12443. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..155 /product="type 1 protein phosphatase-activating protein YPI1" /calculated_mol_wt="18056" Region 29..84 /region_name="PPI_Ypi1" /note="Protein phosphatase inhibitor; pfam07491" /db_xref="CDD:429489" CDS 1..155 /gene="YPI1" /locus_tag="YFR003C" /coded_by="NM_001179968.1:1..468" /experiment="EXISTENCE:direct assay:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:14506263]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18172024|PMID:17142459]" /experiment="EXISTENCE:direct assay:GO:1900180 regulation of protein localization to nucleus [PMID:18172024]" /experiment="EXISTENCE:genetic interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:18172024]" /experiment="EXISTENCE:genetic interaction:GO:0072542 protein phosphatase activator activity [PMID:18172024]" /experiment="EXISTENCE:mutant phenotype:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:14506263]" /experiment="EXISTENCE:mutant phenotype:GO:0005977 glycogen metabolic process [PMID:14506263]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:22367039]" /experiment="EXISTENCE:mutant phenotype:GO:1900180 regulation of protein localization to nucleus [PMID:17142459]" /note="Regulatory subunit of the type I protein phosphatase (PP1) Glc7p; Glc7p participates in the regulation of a variety of metabolic processes including mitosis and glycogen metabolism; in vitro evidence suggests Ypi1p is an inhibitor of Glc7p while in vivo evidence suggests it is an activator; overproduction causes decreased cellular content of glycogen; partial depletion causes lithium sensitivity, while overproduction confers lithium-tolerance" /db_xref="GeneID:850553" /db_xref="SGD:S000001899" ORIGIN 1 msgnqmamgs eqqqtvgsrt vsveevpavl qlratqdppr sqeamptrhn vrweenvidn 61 enmnkkktki ccifhpqned eeecnhhsdd dgssssgsss sesenekdld fnerrqrrle 121 rrhrklekkr syspnayeiq pdyseyrrkq qekkd // LOCUS NP_116659 306 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle lid subunit RPN11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116659 VERSION NP_116659.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179969.1 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 306) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12444. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..306 /product="proteasome regulatory particle lid subunit RPN11" /EC_number="3.4.19.12" /calculated_mol_wt="34267" Region 22..282 /region_name="MPN_RPN11_CSN5" /note="Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5; cd08069" /db_xref="CDD:163700" Site order(48,109,111,119,122) /site_type="active" /note="MPN+ (JAMM) motif [active]" /db_xref="CDD:163700" Site order(109,111,122) /site_type="other" /note="Zinc-binding site [ion binding]" /db_xref="CDD:163700" CDS 1..306 /gene="RPN11" /locus_tag="YFR004W" /gene_synonym="MPR1" /coded_by="NM_001179969.1:1..921" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15210724]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19773362]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:19773362]" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:9741626|PMID:11742986]" /experiment="EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:25389291]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0140492 metal-dependent deubiquitinase activity [PMID:25389291]" /experiment="EXISTENCE:genetic interaction:GO:0016579 protein deubiquitination [PMID:14581483]" /experiment="EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:20941496]" /experiment="EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:19773362]" /experiment="EXISTENCE:mutant phenotype:GO:0016559 peroxisome fission [PMID:19773362]" /experiment="EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:12183636]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:12183636]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:20061387]" /experiment="EXISTENCE:mutant phenotype:GO:0140492 metal-dependent deubiquitinase activity [PMID:12353037|PMID:12183636]" /experiment="EXISTENCE:mutant phenotype:GO:1902906 proteasome storage granule assembly [PMID:23936414]" /note="Metalloprotease subunit of 19S regulatory particle; part of 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850554" /db_xref="SGD:S000001900" ORIGIN 1 merlqrlmmn skvgsadtgr ddtketvyis siallkmlkh gragvpmevm glmlgefvdd 61 ytvnvvdvfa mpqsgtgvsv eavddvfqak mmdmlkqtgr dqmvvgwyhs hpgfgcwlss 121 vdvntqksfe qlnsravavv vdpiqsvkgk vvidafrlid tgalinnlep rqttsntgll 181 nkaniqalih glnrhyysln idyhktaket kmlmnlhkeq wqsglkmydy eekeesnlaa 241 tksmvkiaeq yskrieeeke lteeelktry vgrqdpkkhl setadetlen nivsvltagv 301 nsvaik // LOCUS NP_116660 448 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SAD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116660 VERSION NP_116660.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179970.1 REFERENCE 1 (residues 1 to 448) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 448) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 448) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 448) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12445. Method: conceptual translation. FEATURES Location/Qualifiers source 1..448 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..448 /product="mRNA splicing protein SAD1" /calculated_mol_wt="52036" Region 30..445 /region_name="Peptidase_C19M" /note="A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02669" /db_xref="CDD:239134" Site order(154,159,405,423) /site_type="active" /db_xref="CDD:239134" CDS 1..448 /gene="SAD1" /locus_tag="YFR005C" /coded_by="NM_001179970.1:1..1347" /experiment="EXISTENCE:direct assay:GO:0000245 spliceosomal complex assembly [PMID:24681967]" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:10022888]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10022888]" /note="Conserved zinc-finger domain protein involved in pre-mRNA splicing; critical for splicing of nearly all intron-containing genes; required for assembly of U4 snRNA into the U4/U6 particle" /db_xref="GeneID:850555" /db_xref="SGD:S000001901" ORIGIN 1 mevdnkrrhs edelkqeavk kiksqepnya yletvvrekl dfdsekicci tlsplnvycc 61 lvcghyyqgr hekspafihs idenhhvfln ltslkfymlp qnvqilhdge vqllnsikfa 121 ayptycpkdl edfprqcfdl snrtylngfi gftnaatydy ahsvlllish mvpvrdhfll 181 nhfdnqgefi krlsicvkki wspklfkhhl svddfvsylk vreglnlnpi dprlfllwlf 241 nkicsssndl ksilnhsckg kvkiakvenk peasesvtgk vivkpfwvlt ldlpefspfe 301 dgnsvddlpq initklltkf tksrssstst vfeltrlpqf lifhfnrfdr nsdhpvknrn 361 qtlvefssel eilhvkyrlk anvvhvvikq pstdgnafng dekshwitql ydnksekwie 421 idginttere aellflketf iqvwekqe // LOCUS NP_116661 535 aa linear PLN 30-JUN-2025 DEFINITION putative Xaa-Pro dipeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116661 VERSION NP_116661.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179971.1 REFERENCE 1 (residues 1 to 535) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 535) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 535) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 535) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12446. Method: conceptual translation. FEATURES Location/Qualifiers source 1..535 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..535 /product="putative Xaa-Pro dipeptidase" /calculated_mol_wt="61623" Region 72..192 /region_name="AMP_N" /note="Aminopeptidase P, N-terminal domain; smart01011" /db_xref="CDD:198079" Region 237..508 /region_name="Prolidase" /note="E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro; cd01087" /db_xref="CDD:238520" Site order(299,316,327,412,452,493) /site_type="active" /db_xref="CDD:238520" CDS 1..535 /locus_tag="YFR006W" /coded_by="NM_001179971.1:1..1608" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene" /db_xref="GeneID:850556" /db_xref="SGD:S000001902" ORIGIN 1 mclepislvv fgslvfffgl vkyfkrgerq rtrgilqpey kdkyyyskek geemgevanv 61 neipvkirnh kypakehnlr vkdlllnrnp klskistaff iageelegnk ycdtnkdfrq 121 nryfyhlsgv dipasailfn cstdkltlfl pnideedviw sgmplsldea mrvfdideal 181 yisdlgkkfk elqdfaiftt dldnvhdeni arslipsdpn ffyamdetra ikdwyeiesi 241 rkacqisdks hlavmsalpi elnelqiqae feyhatrqgg rslgydpicc sgpacgtlhy 301 vknsedikgk hsilidagae wrqytsditr cfptsgkfta ehrevyetvl dmqnqameri 361 kpgakwddlh althkvlikh flsmgifkke fsedeifkrr ascafyphgl ghmlgldvhd 421 vggnpnyddp dpmfrylrir rplkenmvit nepgcyfnqf likeflekhp erlevvdmsv 481 lkrymyvggv rieddilvtk dgyenltgit sdpdeiekiv qkglkkprsg fhviv // LOCUS NP_116662 353 aa linear PLN 30-JUN-2025 DEFINITION Yfh7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116662 VERSION NP_116662.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179972.1 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 353) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12447. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..353 /product="Yfh7p" /calculated_mol_wt="39754" Region 9..>105 /region_name="AAA" /note="The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; cd00009" /db_xref="CDD:99707" Site 31..38 /site_type="other" /note="Walker A motif" /db_xref="CDD:99707" Site order(32..39,99) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:99707" Site 95..100 /site_type="other" /note="Walker B motif" /db_xref="CDD:99707" Region <148..353 /region_name="NK" /note="Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; cl17190" /db_xref="CDD:450170" CDS 1..353 /gene="YFH7" /locus_tag="YFR007W" /gene_synonym="AIM12" /coded_by="NM_001179972.1:1..1062" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:18004758]" /note="Putative kinase with similarity to the PRK/URK/PANK kinase subfamily; the PRK/URK/PANK subfamily of P-loop kinases is also known as phosphoribulokinase/uridine kinase/bacterial pantothenate kinase" /db_xref="GeneID:850558" /db_xref="SGD:S000001903" ORIGIN 1 mvdthkladd vlqlldnrie dnyrvcvilv gspgsgksti aeelcqiine kyhtflsehp 61 nvievndrlk pmvnlvdslk tlqpnkvaem ienqglfkdh vedvnfqpvk ysaltsnnee 121 ctavvarggt anairiaavd npvnvnklaq dsiniaqivp mdgfhlsrrc ldlfkdpqta 181 hkrrgspstf dsnnflqlck ilaktslckv sshhkfysts svfeklsktf sqtipdifvp 241 gfnhalkdpt pdqyciskft rivileglyl lydqenwkki yktladtgal lvykididye 301 ateervakrh lqsglvttia egrekfrsnd llngrdidnh likvdnivhi rnd // LOCUS NP_116663 221 aa linear PLN 30-JUN-2025 DEFINITION Far7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116663 VERSION NP_116663.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179973.1 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 221) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12448. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..221 /product="Far7p" /calculated_mol_wt="25784" CDS 1..221 /gene="FAR7" /locus_tag="YFR008W" /coded_by="NM_001179973.1:1..666" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23625923]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]" /note="Protein involved in recovery from pheromone-induced cell cycle arrest; acts in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850559" /db_xref="SGD:S000001904" ORIGIN 1 msdqinvlsm qqqqqqqqqq qqvymspqae nlnhmyllvn klvkqlrenq aekakilrni 61 dilsgslnky etseephdtt enialfnrfl eqrgkapite keqlsnnlde nakddvmlgv 121 lkrqnsmlrk slqeskqvtl esmdllsyse dslnyivaql rgnilmhhke tiklirqkfq 181 tetipledee fkmylenvng lqkltdisht yrlllrlhaq d // LOCUS NP_116664 752 aa linear PLN 30-JUN-2025 DEFINITION putative AAA family ATPase GCN20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116664 VERSION NP_116664.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179974.1 REFERENCE 1 (residues 1 to 752) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 752) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 752) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 752) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12449. Method: conceptual translation. FEATURES Location/Qualifiers source 1..752 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..752 /product="putative AAA family ATPase GCN20" /calculated_mol_wt="84897" Region <190..742 /region_name="PLN03073" /note="ABC transporter F family; Provisional" /db_xref="CDD:215558" CDS 1..752 /gene="GCN20" /locus_tag="YFR009W" /coded_by="NM_001179974.1:1..2259" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:9234705]" /experiment="EXISTENCE:mutant phenotype:GO:0006448 regulation of translational elongation [PMID:9234705]" /experiment="EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:32320318]" /note="Positive regulator of the Gcn2p kinase activity; important for disaggregation of ordered and disordered protein aggregates; forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA; suppresses frameshifting at stalled ribosomes" /db_xref="GeneID:850561" /db_xref="SGD:S000001905" ORIGIN 1 masigsqvrk aassidpivt dyavgyfnhl sgitfdavqs kqvdlstevq fvsdllidag 61 askakvkels esilkqlttq lkeneaklel tgdtskrlld invlkshnsk sdinvslsml 121 gvngdiehtg rkmetrvdlk klakaeqkia kkvakrnnkf vkyeasklin dqkeedydsf 181 flqinplefg ssagkskdih idtfdlyvgd gqrilsnaql tlsfghrygl vgqngigkst 241 llralsrrel nvpkhvsilh veqelrgddt kalqsvldad vwrkqllsee akinerlkem 301 dvlrqefeed slevkkldne redldnhliq isdklvdmes dkaearaasi lyglgfstea 361 qqqptnsfsg gwrmrlslar alfcqpdlll ldepsnmldv psiaylaeyl ktypntvltv 421 shdraflnev atdiiyqhne rldyyrgqdf dtfyttkeer rknaqreydn qmvyrkhlqe 481 fidkyrynaa ksqeaqsrik kleklpvlep peqdktidfk fpecdklspp iiqlqdvsfg 541 ydennlllkd vnldvqmdsr ialvgangcg kttllkimme qlrplkgfvs rnprlrigyf 601 tqhhvdsmdl ttsavdwmsk sfpgktdeey rrhlgsfgit gtlglqkmql lsggqksrva 661 faalclnnph ilvldepsnh ldttgldalv ealknfnggv lmvshdisvi dsvckeiwvs 721 eqgtvkrfeg tiydyrdyil qsadaagvvk kh // LOCUS NP_116665 499 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease UBP6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116665 VERSION NP_116665.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179975.1 REFERENCE 1 (residues 1 to 499) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 499) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 499) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 499) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12450. Method: conceptual translation. FEATURES Location/Qualifiers source 1..499 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..499 /product="ubiquitin-specific protease UBP6" /EC_number="3.4.19.12" /calculated_mol_wt="56980" Region 5..78 /region_name="Ubl1_cv_Nsp3_N-like" /note="first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; cl28922" /db_xref="CDD:475130" Region 110..495 /region_name="Peptidase_C19A" /note="A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl...; cd02657" /db_xref="CDD:239122" Site order(113,118,447,466) /site_type="active" /db_xref="CDD:239122" CDS 1..499 /gene="UBP6" /locus_tag="YFR010W" /coded_by="NM_001179975.1:1..1500" /experiment="EXISTENCE:direct assay:GO:0000502 proteasome complex [PMID:12408819]" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:17018280|PMID:12408819]" /experiment="EXISTENCE:direct assay:GO:0005838 proteasome regulatory particle [PMID:11029046]" /experiment="EXISTENCE:genetic interaction:GO:0016579 protein deubiquitination [PMID:14581483]" /experiment="EXISTENCE:mutant phenotype:GO:0004843 cysteine-type deubiquitinase activity [PMID:12408819|PMID:17018280]" /experiment="EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:12408819]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:21070972]" /experiment="EXISTENCE:mutant phenotype:GO:1901799 negative regulation of proteasomal protein catabolic process [PMID:17018280]" /note="Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chain; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; human homolog UBP14 complements yeast null mutant" /db_xref="GeneID:850562" /db_xref="SGD:S000001906" ORIGIN 1 msgetfefni rhsgkvypit lstdatsadl kskaeeltqv psarqkymvk gglsgeesik 61 iyplikpgst vmllgtpdan liskpakknn fiedlapeqq vqqfaqlpvg fknmgntcyl 121 natlqalyrv ndlrdmilny npsqgvsnsg aqdeeihkqi viemkrcfen lqnksfksvl 181 pivllntlrk cypqfaerds qggfykqqda eelftqlfhs msivfgdkfs edfriqfktt 241 ikdtandndi tvkenesdsk lqchisgttn fmrngllegl nekiekrsdl tgansiysve 301 kkisrlpkfl tvqyvrffwk rstnkkskil rkvvfpfqld vadmltpeya aekvkvrdel 361 rkvekeknek ereikrrkfd psssenvmtp reqyetqval nesekdqwle eykkhfppnl 421 ekgenpscvy nligvithqg ansesghyqa firdeldenk wykfnddkvs vvekekiesl 481 agggesdsal ilmykgfgl // LOCUS NP_116666 170 aa linear PLN 30-JUN-2025 DEFINITION Mic19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116666 VERSION NP_116666.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179976.1 REFERENCE 1 (residues 1 to 170) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 170) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 170) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 170) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12451. Method: conceptual translation. FEATURES Location/Qualifiers source 1..170 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..170 /product="Mic19p" /calculated_mol_wt="18724" Region 18..168 /region_name="DUF1690" /note="Protein of Unknown function (DUF1690); pfam07956" /db_xref="CDD:429752" CDS 1..170 /gene="MIC19" /locus_tag="YFR011C" /gene_synonym="AIM13; MCS19" /coded_by="NM_001179976.1:1..513" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14562095|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0044284 mitochondrial crista junction [PMID:22009199]" /experiment="EXISTENCE:direct assay:GO:0061617 MICOS complex [PMID:21987634|PMID:22009199|PMID:21944719]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:22009199|PMID:21944719|PMID:21987634]" /note="Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic19p is peripheral to the inner membrane and may connect Mic60p with the Mic10p-Mic12p-Mic27p subcomplex; both yeast and human Mic19p become oxidized, and oxidation may regulate MICOS" /db_xref="GeneID:850563" /db_xref="SGD:S000001907" ORIGIN 1 mgsntskvga gaekqqvytp ltqidfsqsl vsqldsskes dyvtkqnaek fiekkvsqrl 61 snlevetlkk fedtlnnsll sdddkdavdg isssslnnqi eslnkkltlf dqlelqklek 121 yggakgksdk ktdngsisik akltecllan kgkplncyee meefkklvmg // LOCUS NP_116667 202 aa linear PLN 30-JUN-2025 DEFINITION Dcv1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116667 VERSION NP_116667.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179977.1 REFERENCE 1 (residues 1 to 202) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 202) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 202) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 202) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12452. Method: conceptual translation. FEATURES Location/Qualifiers source 1..202 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..202 /product="Dcv1p" /calculated_mol_wt="22304" Region 7..153 /region_name="SUR7" /note="SUR7/PalI family; cl24030" /db_xref="CDD:420163" CDS 1..202 /gene="DCV1" /locus_tag="YFR012W" /coded_by="NM_001179977.1:1..609" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:33002606]" /note="hypothetical protein; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication" /db_xref="GeneID:850565" /db_xref="SGD:S000001908" ORIGIN 1 mlnyklillf ssflqlisfs gfmiccltsp iirnwglaqa agvsygtfgy cktlnsfscs 61 rvrliyntsk eilpgpsler wwlspkarht iggllisipv atcltfisfa lplviiflfq 121 tggtnvslit snailhiltl lstifactvi lllcmhrdpv tisslydlvw lancslfpll 181 vigvhflsfr fdtsaqsdrk hs // LOCUS NP_076889 28 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFR012W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_076889 VERSION NP_076889.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184472.1 REFERENCE 1 (residues 1 to 28) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 28) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 28) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 28) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12453. Method: conceptual translation. FEATURES Location/Qualifiers source 1..28 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..28 /product="uncharacterized protein" /calculated_mol_wt="3246" CDS 1..28 /locus_tag="YFR012W-A" /coded_by="NM_001184472.1:1..87" /note="hypothetical protein; identified by homology" /db_xref="GeneID:850566" /db_xref="SGD:S000007606" ORIGIN 1 mlprkykpay kkqahrvksn pqpaytfq // LOCUS NP_116668 787 aa linear PLN 30-JUN-2025 DEFINITION Ioc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116668 VERSION NP_116668.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179978.1 REFERENCE 1 (residues 1 to 787) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 787) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 787) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 787) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12454. Method: conceptual translation. FEATURES Location/Qualifiers source 1..787 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..787 /product="Ioc3p" /calculated_mol_wt="90766" Region <74..134 /region_name="PRK13808" /note="adenylate kinase; Provisional" /db_xref="CDD:172341" Region 365..411 /region_name="WHIM1" /note="WSTF, HB1, Itc1p, MBD9 motif 1; pfam15612" /db_xref="CDD:464774" CDS 1..787 /gene="IOC3" /locus_tag="YFR013W" /coded_by="NM_001179978.1:1..2364" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0036436 Isw1a complex [PMID:12482963]" /experiment="EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:27185881]" /note="Subunit of the Isw1a complex; Isw1a has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; promotes nucleosome shifts in the 5 prime direction; IOC3 has a paralog, ESC8, that arose from the whole genome duplication" /db_xref="GeneID:850567" /db_xref="SGD:S000001909" ORIGIN 1 mdspsnsiqn lqqeaqgsss aqladhdhdr vsmamplqtd qsvsvsqssd nlrrsrrvpk 61 prtsiydeye eelkerankp krkrpappkk kapstqnsks ndkvekkktt siakdgkptl 121 ktndkkvapk pkpaheqvep alipsnwtsv iplltsdfkn qysvisrlkn pnmkpvpyag 181 diiklmafin kfssffhsdl qnlsfqdfev gldlypgdpn gsaagivkgp edtslllypd 241 fmaikdivyc qdkmnllfls lldltftenf dgksakkkgp lttwenlkss skkvfsnply 301 rlrlvarewg yprewrqqlp sdqdiskpkt alfeqdeqtp vvdpshpeil tpniytwnan 361 eplplesnpl ynremdkngi lalkpmdrvv llraltdwca shssaihdei yklthgkkdp 421 vfgiqtqqvp rytiegvdnt inqfkklcsl iqsryeirsk kkhfvkqlke gkkpdlsrkl 481 eilkeikael knavksekde llfslydkwv plfegelpdq planpfserl yklrlqeffl 541 grvphigdfy mprlhsygds lemstftdlr nlqallskfk nneynaftlf endgqsmsaq 601 fklfyhdtps lahdvargrn tsgkvywyel chdsatllef lefldykivk pqdekkegne 661 kekealnnea hileqksttd nnpsintnpl pkdakyntar kklqilkefl sdyyfilrqf 721 eqmkvqfadm kpgkrqlrri qrqtvnynte ydseeyvdde eddeadiydd ndndssfddg 781 rvkrqrt // LOCUS NP_116669 446 aa linear PLN 30-JUN-2025 DEFINITION calmodulin-dependent protein kinase CMK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116669 VERSION NP_116669.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179979.2 REFERENCE 1 (residues 1 to 446) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 446) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 446) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 446) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12455. Method: conceptual translation. FEATURES Location/Qualifiers source 1..446 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..446 /product="calmodulin-dependent protein kinase CMK1" /EC_number="2.7.11.17" /calculated_mol_wt="50165" Region 36..298 /region_name="STKc_CAMK" /note="The catalytic domain of CAMK family Serine/Threonine Kinases; cd05117" /db_xref="CDD:270687" Site order(43..47,51,64,66,99,115..118,122,124,160..161,163, 165..166,168,181..182,185,200..204,206) /site_type="active" /db_xref="CDD:270687" Site order(43..46,51,64,66,99,115..118,122,165..166,168, 181..182) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270687" Site order(47,122,124,160..161,163,165,185,200..204,206) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270687" Site order(181..189,200..204) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270687" CDS 1..446 /gene="CMK1" /locus_tag="YFR014C" /coded_by="NM_001179979.2:1..1341" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004683 calcium/calmodulin-dependent protein kinase activity [PMID:2061341]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9756868]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:11743609]" /note="Calmodulin-dependent protein kinase; may play a role in stress response, many Ca++/calmodulin dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to mammalian Cam Kinase II; CMK1 has a paralog, CMK2, that arose from the whole genome duplication" /db_xref="GeneID:850568" /db_xref="SGD:S000001910" ORIGIN 1 mddkvsekes spkqteedse gkmahvqpas yvnkkkyvfg ktlgagtfgv vrqakntetg 61 edvavkilik kalkgnkvql ealydeldil qrlhhpniva fkdwfeskdk fyiitqlakg 121 gelfdrilkk gkfteedavr ilveilsavk ymhsqnivhr dlkpenllyi dksdesplvv 181 adfgiakrlk sdeellykpa gslgyvapev ltqdghgkpc diwsigvity tllcgysafr 241 aervqdflde cttgeypvkf hrpywdsvsn kakqfilkal nldpskrpta aelledpwii 301 ctelkthnll pglkegldar qkfrnsverv rlnmkiqklr dlyleqtesd sdfdegsqan 361 gsvpplkatd tsqlskklse eeqsklksel tskafaqlvn tvlaekekfl ninrvcssds 421 dlpgsdiksl deakekpegk dtktee // LOCUS NP_116670 708 aa linear PLN 30-JUN-2025 DEFINITION glycogen (starch) synthase GSY1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116670 VERSION NP_116670.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179980.1 REFERENCE 1 (residues 1 to 708) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 708) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 708) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 708) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12456. Method: conceptual translation. FEATURES Location/Qualifiers source 1..708 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..708 /product="glycogen (starch) synthase GSY1" /EC_number="2.4.1.11" /calculated_mol_wt="80379" Region 12..683 /region_name="Glycogen_syn" /note="Glycogen synthase; pfam05693" /db_xref="CDD:399009" CDS 1..708 /gene="GSY1" /locus_tag="YFR015C" /coded_by="NM_001179980.1:1..2127" /experiment="EXISTENCE:direct assay:GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity [PMID:2123485]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0005978 glycogen biosynthetic process [PMID:1908457]" /note="Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase; GSY1 has a paralog, GSY2, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:850569" /db_xref="SGD:S000001911" ORIGIN 1 mardlqnhll fevatevtnr vggiysvlks kapvtvaqyg dnytllgpln katyesevek 61 ldwedesifp eellpiqktl msmrekgvnf vygnwliega prvilfelds vrhflnewka 121 dlwslvgips pehdhetnda illgyvvvwf lgevskldss haiighfhew lagvalplcr 181 kkridvvtif tthatllgry lcaagdvdfy nnlqyfdvdq eagkrgiyhr ycieraaaht 241 advfttvsqi taleaehllk rkpdgilpng lnvvkfqavh efqnlhalkk dkindfvrgh 301 fhgcfdfdld ntvyffiagr yeyknkgadm fieslarlny rlkvsgskkt vvaflimpak 361 tnsftvealk sqaivkslen tvnevtasig krifehtmry phngleselp tnldellkss 421 ekvllkkrvl alrrpygelp pvvthnmcdd andpilnqir hvrlfndssd rvkvifhpef 481 lnannpilgl dydefvrgch lgvfpsyyep wgytpaectv mgvpsittnv sgfgaymedl 541 ietdqakdyg iyivdrrfks pdesveqlad ymeefvnktr rqrinqrnrt erlsdlldwk 601 rmgleyvkar qlglrraype qfkqlvgeti sdanmntlag gkkfkiarpl svpgspkvrs 661 nstvymtpgd lgtlqdanna ddyfnlstng aidnddddnd tsayyedn // LOCUS NP_116671 1233 aa linear PLN 30-JUN-2025 DEFINITION Aip5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116671 VERSION NP_116671.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179981.1 REFERENCE 1 (residues 1 to 1233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1233) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 1233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12457. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..1233 /product="Aip5p" /calculated_mol_wt="137567" Region <271..>528 /region_name="2A1904" /note="K+-dependent Na+/Ca+ exchanger; TIGR00927" /db_xref="CDD:273344" Region <482..1082 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" CDS 1..1233 /gene="AIP5" /locus_tag="YFR016C" /coded_by="NM_001179981.1:1..3702" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:31699995]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:31699995]" /experiment="EXISTENCE:direct assay:GO:0032233 positive regulation of actin filament bundle assembly [PMID:31699995]" /note="Protein that positively regulates actin assembly; forms a homodimer and interacts with G-actin; localization to the bud neck and bud tip requires Spa2p; YFR016C is not an essential gene" /db_xref="GeneID:850570" /db_xref="SGD:S000001912" ORIGIN 1 mvesltvenq ehnvqppsvt sagdsystla tdlplpstnd iiesrdqlte sdldeainat 61 enfaqelssq rkssklkghk kknqgqikan rdrdtivkls ssvgeteeas trdaishdle 121 rkddvieiat dtindatesp tqipidvnvv iketstnnva egtenvppik estgievgns 181 pitrrkknkk kkttnrrgrn ssnpadttdl skqstldsil vgieeylqed gsknedikvn 241 ivqdepvnve kmdirtrnes sdktfdidvp nkdnvdetss ksennineek aehtlpreen 301 eilnvnegna asfkhqleph gleagdengq astkdveses ltkngfnfke neskhlkage 361 kqqtesdrdg ispsvlaknq keteigkedh vfeqkdkede kcrkelsvnh ennmshnfna 421 agsdsiippe teretyddet mgptkrisdn eknlqhgtnd isvevekeee eeeeeeenst 481 fskvkkenvt geqeavrnne vsgteeests kgeeimggde kqseagekss iieiegsans 541 akiskdnlvl edeaeaptqe nkptevvgei dipdaprddv eiveavekni ipedlevake 601 dqegeqvkld epvkamkddk iamrgaesis edmkkkqegt aelsnekakk evdetaresa 661 egvevekskt pespkvvkrc tsgrpedlqi nerdpevlke dvrvpdedvk peiattiens 721 eeedpksqrv qisteqaett qkdmgdvgst tsfkeeekpk rfeitqegdk itgkdtnheh 781 geateaasen skasdvgtae kyiepssesv kkdteedaev ensektefik vkaelenlda 841 pkeaevtael nkenedvevd teedaevens ektefikvka elgnldapke aevtaelnke 901 nedvevaats kedietkcse paetpiedgt cteaevskkd aeavtkeden menskiaeal 961 kdvtgdqeid dinisdefqr tvelpelekq dikdnkgedk eleveeteke tslpdlvvee 1021 niteekneik qeeeevsqld fnetesiske apnndengfe dqstrenpkk asaddifkdi 1081 ldetnefleq lkivddseln allqsldakd sttqtteqsk knndkpqdvi ttseirklne 1141 kepvyiytsl agggfhmipr tnrlstilta nripftyrdl gtddearkvw ktfskgrslp 1201 gvvrghndli gnweeieean edyklreliy dti // LOCUS NP_116672 195 aa linear PLN 30-JUN-2025 DEFINITION Igd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116672 VERSION NP_116672.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179982.1 REFERENCE 1 (residues 1 to 195) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 195) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 195) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 195) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12458. Method: conceptual translation. FEATURES Location/Qualifiers source 1..195 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..195 /product="Igd1p" /calculated_mol_wt="21652" CDS 1..195 /gene="IGD1" /locus_tag="YFR017C" /coded_by="NM_001179982.1:1..588" /experiment="EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:21585652]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004857 enzyme inhibitor activity [PMID:21585652]" /experiment="EXISTENCE:mutant phenotype:GO:0045818 negative regulation of glycogen catabolic process [PMID:21585652]" /note="Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation; protein abundance increases in response to DNA replication stress; IGD1 has a paralog, YOL024W, that arose from the whole genome duplication" /db_xref="GeneID:850572" /db_xref="SGD:S000001913" ORIGIN 1 mtdphlntpq vstsptfers qdflnidepp caqetpsvst fnlpgpsapa qsvdkpvpmi 61 rrrstnymda lnsreqarer essigehapg aerrssgpmd fqntihnmqy rttndsdlsh 121 agvdmgdsis htpicsragn rpifknsyld nnsngnsarv phgsppqlgt rrkssfkyed 181 fkkdiynqlh mfgek // LOCUS NP_116673 363 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFR018C [Saccharomyces cerevisiae S288C]. ACCESSION NP_116673 VERSION NP_116673.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179983.1 REFERENCE 1 (residues 1 to 363) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 363) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 363) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 363) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12459. Method: conceptual translation. FEATURES Location/Qualifiers source 1..363 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..363 /product="uncharacterized protein" /calculated_mol_wt="40900" Region 36..356 /region_name="M28_QC_like" /note="M28 Zn-peptidase glutaminyl cyclase; cd03880" /db_xref="CDD:349876" Site order(141,192..194,198,203..204,230..231,302..303,320,324, 328..329) /site_type="active" /db_xref="CDD:349876" CDS 1..363 /locus_tag="YFR018C" /coded_by="NM_001179983.1:1..1092" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and seamless GFP fusion proteins localize to the endoplasmic reticulum and mCherry fusion protein localizes to the vacuole" /db_xref="GeneID:850573" /db_xref="SGD:S000001914" ORIGIN 1 mgmkyvlplr liglayllvl fqvhrvtgwe lsyeqyhaah lneainpdsg wnkstknlll 61 pfnrtrvpgs egsreiqrfi iehfnntlag ewavetqafe engyrfnnlv mtlqnnasey 121 lvlaahydtk iaptgmvgai dsaascaall ytaqflthia chertkeynd lesntvvsns 181 tlgvkivffd geeaieewgp edsiygarrl aaqwladgtm trirllflld llgsgeeepl 241 vpsyyaethq eyqllnried dllfrrgdei ngesalaaev arqrkhldpt dyrflglghs 301 vigddhtpfl aagvpvlhai plpfpstwht vdddfrhlda aetrhwallv cefvvqslrs 361 rnq // LOCUS NP_116674 2278 aa linear PLN 30-JUN-2025 DEFINITION 1-phosphatidylinositol-3-phosphate 5-kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116674 VERSION NP_116674.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179984.2 REFERENCE 1 (residues 1 to 2278) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2278) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2278) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 2278) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 2278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12460. On Apr 26, 2011 this sequence version replaced NP_116674.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2278 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..2278 /product="1-phosphatidylinositol-3-phosphate 5-kinase" /EC_number="2.7.1.150" /calculated_mol_wt="257290" Region <64..>145 /region_name="PHA03255" /note="BDLF3; Provisional" /db_xref="CDD:165513" Region 236..296 /region_name="FYVE_like_SF" /note="FYVE domain like superfamily; cl28890" /db_xref="CDD:333710" Site order(258..263,268,289) /site_type="other" /note="phosphatidylinositol 3-phosphate binding site [chemical binding]" /db_xref="CDD:277249" Region 797..1056 /region_name="Fab1_TCP" /note="TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this...; cd03334" /db_xref="CDD:239450" Region 1597..2278 /region_name="MSS4" /note="Phosphatidylinositol-4-phosphate 5-kinase [Signal transduction mechanisms]; COG5253" /db_xref="CDD:227578" CDS 1..2278 /gene="FAB1" /locus_tag="YFR019W" /gene_synonym="SVL7" /coded_by="NM_001179984.2:1..6837" /experiment="EXISTENCE:direct assay:GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity [PMID:9811604]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11889142|PMID:9763421]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:9763421|PMID:11889142]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:9702203]" /experiment="EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:9811604]" /experiment="EXISTENCE:direct assay:GO:0070772 PAS complex [PMID:19037259]" /experiment="EXISTENCE:mutant phenotype:GO:0000285 1-phosphatidylinositol-3-phosphate 5-kinase activity [PMID:9811604|PMID:9763421]" /experiment="EXISTENCE:mutant phenotype:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:9811604|PMID:9763421]" /experiment="EXISTENCE:physical interaction:GO:0070772 PAS complex [PMID:19037259]" /note="1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis" /db_xref="GeneID:850574" /db_xref="SGD:S000001915" ORIGIN 1 msseephasi sfpdgshvrs sstgtssvnt idatlsrpny ikkpslhims tsttstttdl 61 vtnpilsnis vpkispptss siatatstsh vtgtashsni kanantstsv nkknlpptts 121 gripsstikr ypsrykpshs lqlpikndsn fkrssiyask stvtaipirn nrpismqnsy 181 artpdsdhdd vgdevssiks asssltasls ksflfafynn rkkdktsnng vlskeywmkd 241 esskecfscg ktfntfrrkh hcricgqifc ssctllidgd rfgchakmrv cyncyehadt 301 yedssdeend stmqlneprs rsrsrssntn pyshshshlh lisqdnhngt dlhdpvaatd 361 npqqqnevyl lndddvqsim tsgedsklfi stpppppkma ipatkqggsl eisfdsendr 421 alhyqddnpg rhhhldsvpt rytirdmdni shydtnsnst lrphyntnns titinnlnnt 481 tsnnsnynnt nsnsninnpa hslrrsifhy vssnsvnkds nnssatpass aqsssildpa 541 nriignyahr nykfkfnyns kgpsqqndta ngnndnnnnn nnnnnnnnnn sasgiadnnn 601 ipsndngttf tldkkkrnpl tkskstsayl eyplneedss edegsmsiys vlnddhktdn 661 pirsmrnstk sfqraqaslq rmrfrrksks khfpnnskss iyrdlnfltn stpnllsvvs 721 ddnlyddssp lqdkasssaa srltdrkfsn ssgsnnnsns nsnintdpwk riasisgfkl 781 kkekkrelne vsllhmhall kqllndqeis nlqewitlld galrkvlrti lnardlntld 841 frqtyvkikr isggspqnse yidgvvfska lpsktmprhl knprillimf pleyqknnnh 901 flsiesvfrq ereyldklvs rlkslhpdii yvganvsgya lellndsgiv vqfnmkpqvi 961 eriakltead iaisvdklat nikmgecetf evksyiygni sktytflrgc npelggtill 1021 rgdslenlrk ikqvsefmvy aifslkless ffndnfiqls tdvylkraes kklqvfegyf 1081 adflikfnnr iltvsptvdf pipfllekar glekklieri nqyesesdld rqtqlnmlqg 1141 lestitkkhl gnlikflhem eienlelefq krsrqwevsy sssqnllgtg shqsitvlys 1201 mvstktatpc vgpqivtidy fwdsdisigq fienvvgtar ypcqqgcngl yldhyrsyvh 1261 gsgkvdvlie kfqtrlpklk diiltwsyck kcgtstpilq isektwnhsf gkylevmfws 1321 ykdsvtgigk cphdftkdhv kyfgyndlvv rleysdlevh elitpprkik wkphidiklk 1381 velyykilek innfygsvls rlerikldsm tkdkvlsgqa kiielksnat eeqklmlqdl 1441 dtfyadspcd qhlplnlvik slydkavnwn stfaifaksy lpsetdisri takqlkklfy 1501 dssrkdsedk kslhdekakt rkpeknelpl eglkdvekpk idsknttenr drtnepqnav 1561 tittfkddtp iiptsgtshl tvtpsassvs ssltpqteer ppisrsgtgi smthdkstrp 1621 nirkmssdss lcglaslane ysknnkvskl atffdqmhfd alskefeler ererlqlnkd 1681 kyqairlqts tpiveiyknv kdavdeplhs rssgnnlssa nvktleapvg ehsranncnp 1741 pnldqnlete lensisqwge nilnpsgktt asthlnskpv vketsenpks ivresdnsks 1801 eplppvittt tvnkvestpq peksllmktl snfwadrsay lwkplvyptc psehiftdsd 1861 viiredepss liafclstsd yrnkmmnlnv qqqqqqqtae aapaktggns ggttqtgdps 1921 vnispsvstt shnkgrdsei sslvttkegl lntppiegar drtpqesqth sqanldtlqe 1981 lekimtkkta thlryqfeeg ltvmsckiff tehfdvfrki cdcqenfiqs lsrcvkwdsn 2041 ggksgsgflk tlddrfiike lshaeleafi kfapsyfeym aqamfhdlpt tlakvfgfyq 2101 iqvkssisss ksykmdviim enlfyekktt rifdlkgsmr nrhveqtgka nevlldenmv 2161 eyiyespihv reydkkllra svwndtlfla kmnvmdyslv igidnegytl tvgiidfirt 2221 ftwdkklesw vkekglvgga svikqptvvt prqykkrfre ameryilmvp dpwyregn // LOCUS NP_001257674 232 aa linear PLN 30-JUN-2025 DEFINITION Css2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257674 VERSION NP_001257674.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270745.1 REFERENCE 1 (residues 1 to 232) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 232) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 232) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 232) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35105. Method: conceptual translation. FEATURES Location/Qualifiers source 1..232 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..232 /product="Css2p" /calculated_mol_wt="25590" CDS 1..232 /gene="CSS2" /locus_tag="YFR020W" /coded_by="NM_001270745.1:1..699" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein, secreted when constitutively expressed; SWAT-GFP fusion protein localizes to the endoplasmic reticulum (ER) and extracellular region, while mCherry fusion protein localizes to the ER and vacuole; mRNA identified as translated by ribosome profiling data; CSS2 is a non-essential gene" /db_xref="GeneID:850576" /db_xref="SGD:S000001916" ORIGIN 1 mwcyshflli fvsfvtsfah klpannsttn ggtdgiavpv iettidsgmy sengtdlmtp 61 edlpdllsdg ivlsfantte tgsdsdstli dsedlrrcid mpdrscsaqr gnlcsysfwd 121 ipfsflntvh difgmtnmgn cavmagdkga fyykyypvep ncnstihqkt iddalqqate 181 qlngdfnnmy ffhvnrgglw qgdmmvgtrv ftwfagakwa ehkgsieagf ts // LOCUS NP_444297 500 aa linear PLN 30-JUN-2025 DEFINITION phosphoinositide binding protein ATG18 [Saccharomyces cerevisiae S288C]. ACCESSION NP_444297 VERSION NP_444297.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179986.1 REFERENCE 1 (residues 1 to 500) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 500) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 500) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 500) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12461. Method: conceptual translation. FEATURES Location/Qualifiers source 1..500 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..500 /product="phosphoinositide binding protein ATG18" /calculated_mol_wt="54971" Region <224..>319 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 249..285 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..500 /gene="ATG18" /locus_tag="YFR021W" /gene_synonym="AUT10; CVT18; NMR1; SVP1" /coded_by="NM_001179986.1:1..1503" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922|PMID:15103325|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:18769150]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11707261]" /experiment="EXISTENCE:direct assay:GO:0006624 vacuolar protein processing [PMID:11707261]" /experiment="EXISTENCE:direct assay:GO:0016236 macroautophagy [PMID:11707261]" /experiment="EXISTENCE:direct assay:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:11707261]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:15103325|PMID:15155809]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:15155809]" /experiment="EXISTENCE:direct assay:GO:0070772 PAS complex [PMID:19037259]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:15103325]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:11739783]" /experiment="EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:11707261]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11707261]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:11707261|PMID:16876790]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044090 positive regulation of vacuole organization [PMID:17699591]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:15103325]" /experiment="EXISTENCE:physical interaction:GO:0070772 PAS complex [PMID:19037259]" /note="Phosphoinositide binding protein; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (CVT) pathway; binds PtdIns(3,5)P2, PI3P and PI4P; WD-40 repeat-containing protein and PROPPIN family member; relocalizes from the vacuole to cytoplasm upon replication stress; forms higher order helical assemblies; mammalian homologs include: WIPI1, WIPI2, WIPI3 and WDR45; human WDR45 mutations cause static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)" /db_xref="GeneID:850577" /db_xref="SGD:S000001917" ORIGIN 1 msdssptinf infnqtgtci slgtskgfki fncepfgkfy sedsggyaiv emlfstslla 61 lvgigdqpal sprrlriint kkhsiicevt fptsilsvkm nksrlvvllq eqiyiydint 121 mrllhtietn pnprglmams psvansylvy psppkvinse ikahattnni tlsvggntet 181 sfkrdqqdag hsdisdldqy ssftkrddad ptssnggnss iikngdvivf nletlqptmv 241 ieahkgeiaa maisfdgtlm atasdkgtii rvfdietgdk iyqfrrgtya triysisfse 301 dsqylavtgs sktvhifklg hsmsnnklds ddsnmeeaaa ddssldttsi dalsdeenpt 361 rlarepyvda srktmgrmir yssqklsrra artlgqifpi kvtsllessr hfaslklpve 421 tnshvmtiss igspididts eypelfetgn sastesyhep vmkmvpirvv ssdgylynfv 481 mdperggdcl ilsqysilmd // LOCUS NP_116677 733 aa linear PLN 30-JUN-2025 DEFINITION Rog3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116677 VERSION NP_116677.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179987.3 REFERENCE 1 (residues 1 to 733) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 733) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 733) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 733) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12462. On Jul 30, 2012 this sequence version replaced NP_116677.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..733 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..733 /product="Rog3p" /calculated_mol_wt="79578" Region <156..215 /region_name="Arrestin_N" /note="Arrestin (or S-antigen), N-terminal domain; cl22903" /db_xref="CDD:451447" Region 232..393 /region_name="Arrestin_C" /note="Arrestin (or S-antigen), C-terminal domain; smart01017" /db_xref="CDD:214976" CDS 1..733 /gene="ROG3" /locus_tag="YFR022W" /gene_synonym="ART7" /coded_by="NM_001179987.3:1..2202" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0031625 ubiquitin protein ligase binding [PMID:24820415]" /experiment="EXISTENCE:genetic interaction:GO:0000747 conjugation with cellular fusion [PMID:24820415]" /experiment="EXISTENCE:genetic interaction:GO:0002092 positive regulation of receptor internalization [PMID:24820415]" /experiment="EXISTENCE:genetic interaction:GO:0071444 cellular response to pheromone [PMID:24820415]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:24820415]" /experiment="EXISTENCE:mutant phenotype:GO:0031625 ubiquitin protein ligase binding [PMID:24820415]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:24820415]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]" /note="Alpha-arrestin involved in ubiquitin-dependent endocytosis; contributes to desensitization of agonist-occupied alpha-factor receptor Ste2p by Rsp5p-independent internalization; PPXY motif-mediated binding of the ubiquitin ligase Rsp5p is not required for adaptation; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; SWAT-GFP and mCherry fusion proteins localize to the cytosol; ROG3 has a paralog, ROD1, that arose from the whole genome duplication" /db_xref="GeneID:850578" /db_xref="SGD:S000001918" ORIGIN 1 mgfssgkstk kkpllfdirl knvdndvill kgppneapsv llsgcivlsi nepmqiksis 61 lrlygkiqid vplerpqdas ssslsssppk irkynkvfyn yawdnvnlke ylsglrgqsg 121 lagsssssni lgtrqraqst sslkslkgss spssctldkg nydfpfsail pgslpesves 181 lpncfvtysm esvierskny sdlicrknir vlrtispaav elsetvcvdn swpdkvdysi 241 svpnkavaig satpinisiv plskglklgs ikvvlfenyq ycdpfppvis enrqvtelnl 301 edplnessge fngngcfvnn pffqpdhsfq dkweidtilq ipnslsncvq dcdvrsnikv 361 rhklkffiil inpdghksel raslpiqlfi spfvalsikp lsssnlyslf sttnqkdens 421 sqeeeeeylf srsasvtgle lladmrsggs vptisdlmtp pnyemhvydr lysgsftrta 481 vetsgtctpl gsecstvedq qqdledlrir ltkirnqrdn lglppsassa aasrslspll 541 nvpapedgte rilpqsalgp nsgsvpgvhs nvspvllsrs papsvsahev lpvpsglnyp 601 etqnlnkvps ygkamkydii gedlppsypc aiqnvqprkp srvhsrnsst tlsssiptsf 661 hsssfmssta spisiingsr ssssgvslnt lneltsktsn npssnsmkrs ptrrratsla 721 gfmggflskg nkr // LOCUS NP_116678 611 aa linear PLN 30-JUN-2025 DEFINITION Pes4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116678 VERSION NP_116678.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179988.1 REFERENCE 1 (residues 1 to 611) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 611) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 611) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 611) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12463. Method: conceptual translation. FEATURES Location/Qualifiers source 1..611 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..611 /product="Pes4p" /calculated_mol_wt="70712" Region 93..>461 /region_name="PABP-1234" /note="polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628" /db_xref="CDD:130689" CDS 1..611 /gene="PES4" /locus_tag="YFR023W" /coded_by="NM_001179988.1:1..1836" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:28193845]" /experiment="EXISTENCE:genetic interaction:GO:0006417 regulation of translation [PMID:28193845]" /experiment="EXISTENCE:genetic interaction:GO:0010609 mRNA localization resulting in post-transcriptional regulation of gene expression [PMID:28193845]" /experiment="EXISTENCE:genetic interaction:GO:0016071 mRNA metabolic process [PMID:28193845]" /experiment="EXISTENCE:genetic interaction:GO:0043934 sporulation [PMID:28193845]" /note="Putative RNA binding protein; partially redundant function with paralog MIP6 in the steady-state expression, translational timing and localization of a subset of Ndt80-dependent mRNAs that are protected until translated near the end of meiosis II; regulator of meiotic commitment; redundant function with MIP6 in sporulation; localizes to puncta near the openings of the prospore membrane; suppressor of a DNA polymerase epsilon mutation; induced by NDT80" /db_xref="GeneID:850579" /db_xref="SGD:S000001919" ORIGIN 1 mysisnkkps ilsmvplnil knqdlkvkkd qekkisfnpv vtpirpddyh ektsrsssss 61 hsdspeflri nnnksghkng klksfeskkl vplfigdlhe tvteetlkgi fkkypsfvsa 121 kvcldsvtkk slghgylnfe dkeeaekame elnytkvngk eirimpslrn ttfrknfgtn 181 vffsnlplnn pllttrvfyd tfsrygkils ckldsrkdig fvyfedekta rnvikmynnt 241 sffgkkilcg ihfdkevrsv pnfetqksrl daetiiekeq slnekhskgn dkeskniyss 301 sqnsifiknl ptittrddil nffsevgpik siylsnatkv kylwafvtyk nssdsekaik 361 rynnfyfrgk kllvtraqdk eerakfiesq kistlflenl savcnkeflk ylchqenirp 421 fkiqidgyde nsstysgfik frnfedatri fnflnnrlvg gsivttswer qnnapkyhdg 481 ygmrnihtss hpqitpyyqy shanslnsph mrdlssmnss trsliknknf nkkvletfek 541 qvrrgidfmr fpsatrdenv hgiaeyifdt ywnrdvlild kflsllnssp yhegvlqkqi 601 eeaasslgfk r // LOCUS NP_219497 459 aa linear PLN 30-JUN-2025 DEFINITION Lsb3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_219497 VERSION NP_219497.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180865.3 REFERENCE 1 (residues 1 to 459) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 459) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 459) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 459) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12464. On Jul 30, 2012 this sequence version replaced NP_219497.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..459 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..459 /product="Lsb3p" /calculated_mol_wt="49213" Region 13..213 /region_name="SYLF_SH3YL1_like" /note="The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins; cd11525" /db_xref="CDD:211401" Site 13..26 /site_type="other" /note="putative amphipathic alpha helix" /db_xref="CDD:211401" Site order(16..17,20,23) /site_type="other" /note="putative lipid binding residues [chemical binding]" /db_xref="CDD:211401" Region 404..458 /region_name="SH3_Ysc84p_like" /note="Src homology 3 domain of Ysc84p and similar fungal proteins; cd11842" /db_xref="CDD:212776" Site order(409,411,414,418,438..439,452,454..455) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212776" CDS 1..459 /gene="LSB3" /locus_tag="YFR024C-A" /gene_synonym="YFR024C" /coded_by="NM_001180865.3:1..1380" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:19158382]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:19158382]" /note="Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication" /db_xref="GeneID:850580" /db_xref="SGD:S000002968" ORIGIN 1 mginnpiprs lksetkkaak ilasfvkpnq vfgadqvipp dvlkrakgla iitilkagfl 61 fsgragsgvi varlkdgtws apsaiamaga gaggmvgiel tdfvfilntq davksfsefg 121 titlggnvsv sagplgrsae aaasasaggv aavfaysksk glfagvsveg saiierrean 181 rkfygdncta kmilsgrirp ppavdplfrv lesrafnyrp snggrgsfdd deddyydddd 241 yyndipssfs stdasstrpn trstrrraqs gsrytfdddd ddddygtgys rnsrlaptns 301 ggsggklddp sgassyyash rrsgtaqsra rssrnrwadd eyddydddye sgyrrgngrd 361 rtkdrevddl snrfsksris sastpqtsqg rftaptspst sspkavalys fageesgdlp 421 frkgdvitil kksdsqndww tgrvngregi fpanyvelv // LOCUS NP_116681 335 aa linear PLN 30-JUN-2025 DEFINITION histidinol-phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116681 VERSION NP_116681.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179990.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 335) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12465. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..335 /product="histidinol-phosphatase" /EC_number="3.1.3.15" /calculated_mol_wt="38451" Region 2..292 /region_name="hisJ_fam" /note="histidinol phosphate phosphatase, HisJ family; TIGR01856" /db_xref="CDD:273837" Site order(5,7,14,39,99,130,180,276,278) /site_type="active" /db_xref="CDD:213994" Site order(8..10,12,14..16,18..19,71..72,75..76,78..80,82) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:213994" CDS 1..335 /gene="HIS2" /locus_tag="YFR025C" /coded_by="NM_001179990.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000105 L-histidine biosynthetic process [PMID:14190241]" /experiment="EXISTENCE:mutant phenotype:GO:0004401 histidinol-phosphatase activity [PMID:14190241]" /note="Histidinolphosphatase; catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control" /db_xref="GeneID:850581" /db_xref="SGD:S000001921" ORIGIN 1 mhshhshsgd ysahgtdpld svvdqvvnln fhtycltehi prieakfiyp eeqslgknpe 61 evitkletsf knfmshaqei ktryadrpdv rtkfiigmei escdmahiey akrlmkennd 121 ilkfcvgsvh hvngipidfd qqqwynslhs fndnlkhfll syfqsqyeml inikplvvgh 181 fdlyklflpn dmlvnqksgn cneetgvpva sldvisewpe iydavvrnlq fidsyggaie 241 intsalrkrl eepypsktlc nlvkkhcgsr fvlsddahgv aqvgvcydkv kkyivdvlql 301 eyicyleesq spenlltvkr lpisqfvndp fwani // LOCUS NP_116682 169 aa linear PLN 30-JUN-2025 DEFINITION Uli1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116682 VERSION NP_116682.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179991.3 REFERENCE 1 (residues 1 to 169) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 169) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 169) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 169) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12466. On Jul 30, 2012 this sequence version replaced NP_116682.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..169 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..169 /product="Uli1p" /calculated_mol_wt="18678" CDS 1..169 /gene="ULI1" /locus_tag="YFR026C" /coded_by="NM_001179991.3:1..510" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:19073890]" /note="hypothetical protein; involved in and induced by the endoplasmic reticulum unfolded protein response (UPR); SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum" /db_xref="GeneID:850583" /db_xref="SGD:S000001922" ORIGIN 1 mtpyavaitv allivtvsal qvnnscvafp psnlrgkngd gtneqyatal lsipwngppe 61 slrdinliel epqvalylle nyinhyyntt rdnkcpnnhy lmggqlgsss dnrslndpqt 121 mlwpekkede kncqetfkga csctkrfckg yfsvnifgin lnisyssgk // LOCUS NP_116683 281 aa linear PLN 30-JUN-2025 DEFINITION Eco1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116683 VERSION NP_116683.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179992.1 REFERENCE 1 (residues 1 to 281) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 281) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 281) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 281) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12467. Method: conceptual translation. FEATURES Location/Qualifiers source 1..281 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..281 /product="Eco1p" /calculated_mol_wt="31714" Region 18..57 /region_name="zf-C2H2_3" /note="zinc-finger of acetyl-transferase ESCO; pfam13878" /db_xref="CDD:464013" Region 209..267 /region_name="Acetyltransf_13" /note="ESCO1/2 acetyl-transferase; pfam13880" /db_xref="CDD:464015" CDS 1..281 /gene="ECO1" /locus_tag="YFR027W" /gene_synonym="CTF7" /coded_by="NM_001179992.1:1..846" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:11448778]" /experiment="EXISTENCE:direct assay:GO:0016407 acetyltransferase activity [PMID:18614053|PMID:22593213|PMID:11864574]" /experiment="EXISTENCE:direct assay:GO:0018393 internal peptidyl-lysine acetylation [PMID:18614053]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16962805]" /experiment="EXISTENCE:genetic interaction:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:16934511]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:9990856]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:11448778]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:19948494]" /experiment="EXISTENCE:mutant phenotype:GO:0016407 acetyltransferase activity [PMID:22593213]" /experiment="EXISTENCE:mutant phenotype:GO:0032200 telomere organization [PMID:19948494]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:9990855|PMID:9990856]" /experiment="EXISTENCE:mutant phenotype:GO:0034089 establishment of meiotic sister chromatid cohesion [PMID:35103590]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:19948494]" /experiment="EXISTENCE:mutant phenotype:GO:0070058 tRNA gene clustering [PMID:19948494]" /experiment="EXISTENCE:mutant phenotype:GO:0140588 chromatin looping [PMID:32032532]" /note="Acetyltransferase required for sister chromatid cohesion; elicits cohesin dimerization during S phase; acetylates Mps3p to regulate nuclear organization; modifies Smc3p at replication forks and Mcd1p in response to dsDNA breaks; phosphorylated by Cdc28p, Cdc7p, Mck1p to generate pair of phosphates spaced precisely for recognition by ubiquitin ligase SCF-Cdc4; relative distribution to nucleus increases upon DNA replication stress; mutations in human homolog ESCO2 cause Roberts syndrome" /db_xref="GeneID:850584" /db_xref="SGD:S000001923" ORIGIN 1 mkarksqrka gskpnliqsk lqvnngsksn kivkcdkcem sysstsiedr aihekyhtlq 61 lhgrkwspnw gsivyternh srtvhlsrst gtitplnssp lkksspsith qeekivyvrp 121 dksngevram teimtlvnne lnaphdenvi wnstteekgk afvyirndra vgiiiienly 181 ggngktssrg rwmvydsrrl vqnvypdfki gisriwvcrt arklgiatkl idvarenivy 241 gevipryqva wsqptdsggk laskyngimh ksgklllpvy i // LOCUS NP_116684 551 aa linear PLN 30-JUN-2025 DEFINITION phosphoprotein phosphatase CDC14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116684 VERSION NP_116684.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179993.3 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 551) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12468. On Jul 30, 2012 this sequence version replaced NP_116684.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..551 /product="phosphoprotein phosphatase CDC14" /EC_number="3.1.3.48" /calculated_mol_wt="61776" Region 12..151 /region_name="DSPn" /note="Dual specificity protein phosphatase, N-terminal half; pfam14671" /db_xref="CDD:464252" Region 161..340 /region_name="CDC14_C" /note="C-terminal dual-specificity phosphatase domain of CDC14 family proteins; cd14499" /db_xref="CDD:350349" Region 403..>513 /region_name="PRK08581" /note="amidase domain-containing protein" /db_xref="CDD:236304" CDS 1..551 /gene="CDC14" /locus_tag="YFR028C" /gene_synonym="OAF3" /coded_by="NM_001179993.3:1..1656" /experiment="EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:24319056|PMID:9295359|PMID:17173039|PMID:24954044]" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:35238874|PMID:26085509]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26090959|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:36259662|PMID:12062061|PMID:26090959]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26090959]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:12062061]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:36259662]" /experiment="EXISTENCE:direct assay:GO:0010508 positive regulation of autophagy [PMID:35238874]" /experiment="EXISTENCE:direct assay:GO:0030869 RENT complex [PMID:10219244]" /experiment="EXISTENCE:direct assay:GO:0044732 mitotic spindle pole body [PMID:36259662]" /experiment="EXISTENCE:direct assay:GO:0071958 new mitotic spindle pole body [PMID:36259662]" /experiment="EXISTENCE:direct assay:GO:0140013 meiotic nuclear division [PMID:35238874]" /experiment="EXISTENCE:genetic interaction:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:26085509]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:6749599]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:29694832]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:25371407]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16769819]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:10219244]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19158678]" /experiment="EXISTENCE:mutant phenotype:GO:0032467 positive regulation of cytokinesis [PMID:25371407]" /experiment="EXISTENCE:mutant phenotype:GO:0051229 meiotic spindle disassembly [PMID:12737806]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:35477092]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:25411400]" /experiment="EXISTENCE:mutant phenotype:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:26085509]" /experiment="EXISTENCE:mutant phenotype:GO:2000786 positive regulation of autophagosome assembly [PMID:29694832]" /note="Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response, autophagy during meiosis; downregulates microautophagy induction after TORC1 inactivation; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of cdc14-1 mutant" /db_xref="GeneID:850585" /db_xref="SGD:S000001924" ORIGIN 1 mrrsvyldnt ieflrgrvyl gaydytpedt delvfftved aifynsfhld fgpmnighly 61 rfavifheil ndpenankav vfyssastrq ranaacmlcc ymilvqawtp hqvlqplaqv 121 dppfmpfrda gysnadfeit iqdvvygvwr akekglidlh sfnlesyeky ehvefgdfnv 181 ltpdfiafas pqedhpkgyl atksshlnqp fksvlnffan nnvqlvvrln shlynkkhfe 241 digiqhldli fedgtcpdls ivknfvgaae tiikrggkia vhckaglgrt gcligahliy 301 tygftaneci gflrfirpgm vvgpqqhwly lhqndfrewk yttrislkps eaigglypli 361 sleeyrlqkk klkddkrvaq nniegelrdl tmtppsnghg alsarnssqp stanngsnsf 421 kssavpqtsp gqprkgqngs ntiedinnnr nptshanrkv viesnnsdde smqdtngtsn 481 hypkvsrkkn dissasssrm ednepsatni nnaaddtilr qllpknrrvt sgrrttsaag 541 girkisgsik k // LOCUS NP_116685 678 aa linear PLN 30-JUN-2025 DEFINITION Ptr3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116685 VERSION NP_116685.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179994.1 REFERENCE 1 (residues 1 to 678) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 678) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 678) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 678) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12469. Method: conceptual translation. FEATURES Location/Qualifiers source 1..678 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..678 /product="Ptr3p" /calculated_mol_wt="76155" CDS 1..678 /gene="PTR3" /locus_tag="YFR029W" /gene_synonym="RAA2; SSY3" /coded_by="NM_001179994.1:1..2037" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10409731]" /experiment="EXISTENCE:mutant phenotype:GO:0043200 response to amino acid [PMID:10409731]" /note="Component of the SPS plasma membrane amino acid sensor system; senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes; other members are Ssy1p, Ptr3p, and Ssy5p" /db_xref="GeneID:850587" /db_xref="SGD:S000001925" ORIGIN 1 mhshrqkwgr qtdiarvldd iehdlylpqr lsldgatgtd eshvqygivk dcsvltcgcc 61 iseslfndlc retsnkqtac picqrenvrl lsaikplrdl arqidffrst tgqgesesde 121 lpaivktsps ssslsltpsr ssstaglead nktlsdptvk ekssllelfh ivaskmhnan 181 tevgsdhplt tgttrdqeeh ttkenysssl lepnyddhan wkildnasnt rtvpidnnfs 241 lmstdvtips tanyqtnsah dldeekeyff ancfpmyrkk fqfnthpkfl gtksklfinq 301 sispdctkfa litehkweiy sinpkdnspq lvscgkssge ygpnfnqlte qsssslstts 361 qaskkkkknw sqrfcklsnd fliisgsqni lnvhdihqng kliytyvsrf pircididpr 421 sqiiaygitg kdrhtgaeqa lvviqqitrn kvtlepefpp pititlpyrd pintiqlshd 481 akyltcstal esrfliislq kineprlimk svrsidtsle segitdtklf pgnpnlmcit 541 stafnssplv intkitqing vrtvaqpsml irvdeigcki hkceisprnd aiafldrngs 601 vyimcaptmm dnnekrrtil vetvanayra yesatlrfnp egnklyildr kgtffvedfa 661 yglpqsreit kckqifhk // LOCUS NP_116686 1035 aa linear PLN 30-JUN-2025 DEFINITION sulfite reductase subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_116686 VERSION NP_116686.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179995.3 REFERENCE 1 (residues 1 to 1035) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1035) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1035) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 1035) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12470. On Jul 30, 2012 this sequence version replaced NP_116686.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1035 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..1035 /product="sulfite reductase subunit alpha" /EC_number="1.8.1.2" /calculated_mol_wt="114698" Region 654..1035 /region_name="CyPoR_like" /note="NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via...; cd06207" /db_xref="CDD:99803" Site order(689,817..820,835,837,851..854) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99803" Site order(817,819..820) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99803" Site order(820,987,1033,1035) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:99803" Site order(837..840,890,892,923..924,953..954,961,963,993) /site_type="other" /note="NAD binding pocket [chemical binding]" /db_xref="CDD:99803" Site order(851,854,857) /site_type="other" /note="phosphate binding motif [ion binding]" /db_xref="CDD:99803" Site order(887,891..894,896) /site_type="other" /note="beta-alpha-beta structure motif" /db_xref="CDD:99803" CDS 1..1035 /gene="MET10" /locus_tag="YFR030W" /coded_by="NM_001179995.3:1..3108" /experiment="EXISTENCE:direct assay:GO:0004783 sulfite reductase (NADPH) activity [PMID:6751400]" /experiment="EXISTENCE:direct assay:GO:0009337 sulfite reductase complex (NADPH) [PMID:6751400]" /experiment="EXISTENCE:mutant phenotype:GO:0000103 sulfate assimilation [PMID:7928966|PMID:19236486]" /note="Subunit alpha of assimilatory sulfite reductase; complex converts sulfite into sulfide" /db_xref="GeneID:850588" /db_xref="SGD:S000001926" ORIGIN 1 mpvefatnpf geaknatslp kygtpvtais svlfnnvdsi fayksfsqpd llhqdlkkws 61 ekrgnesrgk pffqeldirs gaglaplgfs hglknttaiv apgfslpyfi nslktvshdg 121 kfllnvgaln ydnatgsvtn dyvtaldaas klkygvvtpi sanevqsval lalaiatfsn 181 nsgainlfdg lnysktvlpl vesvpeasil aklskviapd aafddvldkf neltglrlhn 241 fqyfgaqdae tvfitygsle selfnsaisg nnskiglinv rvplpfnvak fvthvpsttk 301 qivvigqtld gsspsflrsq vsaalfyhgr tsisvseyiy qpdfiwspka vksivssfip 361 eftynadssf gegfiywasd ksinidvask lvkalsledg kfvslrtkfd nlanagtfqa 421 qfvtskeqip vsnidstkls vvedvsllkh ldvaatvaeq gsialvsqka vkdldlnsve 481 syvknlgipe sflisiakkn iklfiidget tndesklslf iqavfwklaf gldvaectnr 541 iwksidsgad isaasisefl tgafknflse vplalytkfs einiekkede eepaalpifv 601 netsflpnns tieeiplpet seisdiakkl sfkeayeven klrpdlpvkn fvvkvkenrr 661 vtpadydryi fhiefdisgt gmtydigeal giharnnesl vkefltfygl nesdvvlvpn 721 kdnhhlletr tvlqafvenl difgkppkrf yeslipyasn eeekkkledl vtpagavdlk 781 rfqdveyyty adifelfpsv rpsleelvti ieplkrreys iassqkvhpn evhllivvvd 841 wvdnkgrkry gqaskyisdl avgselvvsv kpsvmklpps pkqpvimsgl gtglapfkai 901 veeklwqkqq gyeigevfly lgsrhkreey lygelweayk dagiithiga afsrdqpqki 961 yiqdrikenl delktamidn kgsfylcgpt wpvpditqal qdilakdaee rgikvdldaa 1021 ieelkeasry ilevy // LOCUS NP_116687 1170 aa linear PLN 30-JUN-2025 DEFINITION condensin subunit SMC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116687 VERSION NP_116687.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179996.2 REFERENCE 1 (residues 1 to 1170) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1170) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1170) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 1170) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12471. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1170 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..1170 /product="condensin subunit SMC2" /calculated_mol_wt="133798" Region 2..1163 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; pfam02463" /db_xref="CDD:426784" CDS 1..1170 /gene="SMC2" /locus_tag="YFR031C" /coded_by="NM_001179996.2:1..3513" /experiment="EXISTENCE:direct assay:GO:0000217 DNA secondary structure binding [PMID:9727028]" /experiment="EXISTENCE:direct assay:GO:0000796 condensin complex [PMID:10811823]" /experiment="EXISTENCE:direct assay:GO:0003680 minor groove of adenine-thymine-rich DNA binding [PMID:9727028]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16055730]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:9727028]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:9727028]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12719426]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:10811823]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:10811823]" /experiment="EXISTENCE:mutant phenotype:GO:0070058 tRNA gene clustering [PMID:18708579]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:10811823]" /experiment="EXISTENCE:mutant phenotype:GO:1903342 negative regulation of meiotic DNA double-strand break formation [PMID:25103240]" /note="Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; essential SMC chromosomal ATPase family member that forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for clustering of tRNA genes at the nucleolus" /db_xref="GeneID:850589" /db_xref="SGD:S000001927" ORIGIN 1 mkveeliidg fksyatrtvi tdwdpqfnai tglngsgksn ildaicfvlg iasmstvras 61 slqdliykrg qagvtkasvt ivfdntdksn spigftnspq isvtrqvvlg gtskylingh 121 rapqqsvlql fqsvqlninn pnflimqgki tkvlnmkpse ilslieeaag tkmfedrrek 181 aertmskket klqenrtllt eeiepklekl rnekrmflef qstqtdlekt erivvsyeyy 241 nikhkhtsir etlengetrm kmlnefvkkt seeidslned veeiklqkek elhkegtisk 301 lenkenglln eisrlktsls ikvenlndtt ekskalesei asssakliek ksayantekd 361 ykmvqeqlsk qrdlykrkee lvstlttgis stgaadggyn aqlakaktel nevslaikks 421 smkmellkke lltiepklke atkdnelnvk hvkqcqetcd klrarlveyg fdpsrikdlk 481 qredklkshy yqtcknseyl krrvtnlefn ytkpypnfea sfvhgvvgql fqidndniry 541 atalqtcagg rlfnvvvqds qtatqllerg rlrkrvtiip ldkiytrpis sqvldlakki 601 apgkvelain lirfdesitk amefifgnsl icedpetakk itfhpkirar sitlqgdvyd 661 pegtlsggsr ntsesllvdi qkynqiqkqi etiqadlnhv teelqtqyat sqktktiqsd 721 lnlslhkldl akrnldanps sqiiarneei lrdigecene iktkqmslkk cqeevstiek 781 dmkeydsdkg sklnelkkel kllakeleeq eseserkydl fqnleleteq lsseldsnkt 841 llhnhlksie slklensdle gkirgveddl vtvqtelnee kkrlmdidde lneletlikk 901 kqdekkssel elqklvhdln kyksntnnme kiiedlrqkh efledfdlvr nivkqnegid 961 ldtyrerskq lnekfqelrk kvnpnimnmi envekkeaal ktmiktiekd kmkiqetisk 1021 lneykretlv ktwekvtldf gnifadllpn sfaklvpceg kdvtqglevk vklgniwkes 1081 lielsggqrs lialslimal lqfrpapmyi ldevdaaldl shtqnighli ktrfkgsqfi 1141 vvslkegmfa nanrvfrtrf qdgtsvvsim // LOCUS NP_116688 254 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL2 RPL2A [Saccharomyces cerevisiae S288C]. ACCESSION NP_116688 VERSION NP_116688.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180030.3 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 254) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12472. On Jul 30, 2012 this sequence version replaced NP_116688.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..254 /product="60S ribosomal protein uL2 RPL2A" /calculated_mol_wt="27277" Region 1..252 /region_name="PTZ00180" /note="60S ribosomal protein L8; Provisional" /db_xref="CDD:173464" CDS 1..254 /gene="RPL2A" /locus_tag="YFR031C-A" /gene_synonym="RPL5B" /coded_by="NM_001180030.3:1..765" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:18263608]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:18263608]" /note="Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication" /db_xref="GeneID:850590" /db_xref="SGD:S000002104" ORIGIN 1 mgrvirnqrk gagsiftsht rlrqgaaklr tldyaerhgy irgivkqivh dsgrgaplak 61 vvfrdpykyr lreeifiane gvhtgqfiya gkkaslnvgn vlplgsvpeg tivsnveekp 121 gdrgalaras gnyviiighn pdenktrvrl psgakkviss dargvigvia gggrvdkpll 181 kagrafhkyr lkrnswpktr gvamnpvdhp hgggnhqhig kastisrgav sgqkagliaa 241 rrtgllrgsq ktqd // LOCUS NP_116689 289 aa linear PLN 30-JUN-2025 DEFINITION Rrt5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116689 VERSION NP_116689.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179997.1 REFERENCE 1 (residues 1 to 289) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 289) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 289) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 289) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12473. Method: conceptual translation. FEATURES Location/Qualifiers source 1..289 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..289 /product="Rrt5p" /calculated_mol_wt="31734" Region 20..106 /region_name="RRM1_RRT5" /note="RNA recognition motif 1 (RRM1) found in yeast regulator of rDNA transcription protein 5 (RRT5) and similar proteins; cd12409" /db_xref="CDD:409843" Region 132..226 /region_name="RRM2_RRT5" /note="RNA recognition motif 2 (RRM2) found in yeast regulator of rDNA transcription protein 5 (RRT5) and similar proteins; cd12410" /db_xref="CDD:409844" CDS 1..289 /gene="RRT5" /locus_tag="YFR032C" /coded_by="NM_001179997.1:1..870" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /note="hypothetical protein; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation" /db_xref="GeneID:850591" /db_xref="SGD:S000001928" ORIGIN 1 mteqvnndtt sdttttittv yisnlpftas erdlhaflnn ygassvlipt qtvrrfskrh 61 nsnprkplgi afaqfanntl alkaiqdlng tvfqnqklfl klhvpyeads tpdtdvkkpk 121 eknkvkktpe taadtvychd lpdditdsei relfqlyspq eiwiyrskvy rrkcipfaph 181 qitaalvtlq setpigdicd svaktatlrg ksiivkpayv skiqeikqlv kdnltnardp 241 ppaalaepap apapvepaeq vqegqdnaet ndvppppass sdrptvaat // LOCUS NP_116690 59 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL29 RPL29 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116690 VERSION NP_116690.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184311.3 REFERENCE 1 (residues 1 to 59) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 59) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 59) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 59) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12474. On Jul 30, 2012 this sequence version replaced NP_116690.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..59 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..59 /product="60S ribosomal protein eL29 RPL29" /calculated_mol_wt="6538" Region 4..42 /region_name="Ribosomal_L29e" /note="Ribosomal L29e protein family; pfam01779" /db_xref="CDD:460324" CDS 1..59 /gene="RPL29" /locus_tag="YFR032C-A" /coded_by="NM_001184311.3:1..180" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog" /db_xref="GeneID:850592" /db_xref="SGD:S000006437" ORIGIN 1 maksknhtah nqtrkahrng ikkpktykyp slkgvdpkfr rnhkhalhgt akalaaakk // LOCUS NP_878072 87 aa linear PLN 30-JUN-2025 DEFINITION Min10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878072 VERSION NP_878072.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184591.1 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 87) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12475. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..87 /product="Min10p" /calculated_mol_wt="9822" CDS 1..87 /gene="MIN10" /locus_tag="YFR032C-B" /coded_by="NM_001184591.1:1..264" /note="Mitochondrial hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466402" /db_xref="SGD:S000028630" ORIGIN 1 mvasrarenq rysqcrksti fplgfaiisg yiqfqnisil hisrfnplfy nifhsifknp 61 gttiqlestl yyhevpispi gnagsqi // LOCUS NP_116691 147 aa linear PLN 30-JUN-2025 DEFINITION ubiquinol--cytochrome-c reductase subunit 6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116691 VERSION NP_116691.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179998.3 REFERENCE 1 (residues 1 to 147) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 147) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 147) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 147) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12476. On Jul 30, 2012 this sequence version replaced NP_116691.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..147 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..147 /product="ubiquinol--cytochrome-c reductase subunit 6" /calculated_mol_wt="17126" Region 76..147 /region_name="UCR_hinge" /note="Ubiquinol-cytochrome C reductase hinge protein; pfam02320" /db_xref="CDD:460531" CDS 1..147 /gene="QCR6" /locus_tag="YFR033C" /gene_synonym="COR3; UCR6" /coded_by="NM_001179998.3:1..444" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:11914276|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:10873857]" /experiment="EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:8288589]" /experiment="EXISTENCE:mutant phenotype:GO:0008121 quinol-cytochrome-c reductase activity [PMID:8288589]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8288589]" /note="Subunit 6 of the ubiquinol cytochrome-c reductase complex; the complex, also known as the cytochrome bc(1) complex or Complex III, is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1; may be loosely associated with the complex since it is easily released into the intermembrane space" /db_xref="GeneID:850593" /db_xref="SGD:S000001929" ORIGIN 1 mgmlelvgey weqlkitvvp vvaaaedddn eqheekaaeg eekeeengde dededededd 61 dddddedeee eeevtdqled lrehfkntee gkalvhhyee caervkiqqq qpgyadlehk 121 edcveeffhl qhyldtatap rlfdklk // LOCUS NP_116692 312 aa linear PLN 30-JUN-2025 DEFINITION phosphate-sensing transcription factor PHO4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116692 VERSION NP_116692.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179999.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 312) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12477. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..312 /product="phosphate-sensing transcription factor PHO4" /calculated_mol_wt="33958" Region 251..312 /region_name="bHLH_ScPHO4_like" /note="basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae phosphate system positive regulatory protein PHO4 and similar proteins; cd11392" /db_xref="CDD:381398" Site order(251..256,259..260,262..263,291..292) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:381398" Site order(263,265..266,269..270,272..273,276,292..294,296..297, 299..300,302..304,306..307) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:381398" CDS 1..312 /gene="PHO4" /locus_tag="YFR034C" /coded_by="NM_001179999.1:1..939" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18408055]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10320381]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10320381]" /experiment="EXISTENCE:direct assay:GO:0016036 cellular response to phosphate starvation [PMID:10320381]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:2664469|PMID:19158363|PMID:2183025]" /experiment="EXISTENCE:genetic interaction:GO:0016036 cellular response to phosphate starvation [PMID:3915785]" /experiment="EXISTENCE:genetic interaction:GO:0045937 positive regulation of phosphate metabolic process [PMID:3915785]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3915785]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:2183025]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:2196175]" /experiment="EXISTENCE:mutant phenotype:GO:0016036 cellular response to phosphate starvation [PMID:3139496|PMID:10320381|PMID:2183025|PMID:4616940]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:4616940|PMID:3139496]" /note="Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p to the same DNA binding motif and cooperation with Pho2p; function is regulated by phosphorylation at multiple sites and by phosphate availability" /db_xref="GeneID:850594" /db_xref="SGD:S000001930" ORIGIN 1 mgrttsegih gfvddlepks sildkvgdfi tvntkrhdgr edfneqndel nsqenhnsse 61 ngneneneqd slalddldra felvegmdmd wmmpshahhs pattatikpr llysplihtq 121 savpvtispn lvatatstts ankvtknksn sspylnkrrg kpgpdsatsl felpdsvipt 181 pkpkpkpkqy pkvilpsnst rrvspvtakt sssaegvvva sespviaphg sshsrslskr 241 rssgalvddd kreshkhaeq arrnrlaval helaslipae wkqqnvsaap skattveaac 301 ryirhlqqnv st // LOCUS NP_116693 114 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFR035C [Saccharomyces cerevisiae S288C]. ACCESSION NP_116693 VERSION NP_116693.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180000.3 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 114) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12478. On Jul 30, 2012 this sequence version replaced NP_116693.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..114 /product="uncharacterized protein" /calculated_mol_wt="12326" CDS 1..114 /locus_tag="YFR035C" /coded_by="NM_001180000.3:1..345" /note="hypothetical protein; deletion mutant exhibits synthetic phenotype with alpha-synuclein" /db_xref="GeneID:850595" /db_xref="SGD:S000001931" ORIGIN 1 msasdktklc nkgmsrtsrt ttfvitpafr erddegansl ckaflntfsn lksgmfkcll 61 gvgavgtfis tfpqffllpc llcvrcvcvc lcasisyaas aifsfsifff fcla // LOCUS NP_001418067 96 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFR035W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001418067 VERSION NP_001418067.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001431138.1 REFERENCE 1 (residues 1 to 96) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 96) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 96) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 96) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DBA54438. Method: conceptual translation. FEATURES Location/Qualifiers source 1..96 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..96 /product="uncharacterized protein" /calculated_mol_wt="10801" CDS 1..96 /locus_tag="YFR035W-A" /coded_by="NM_001431138.1:1..291" /note="hypothetical protein; added to genome annotation based on evolutionary, translation, and proteomics evidence" /db_xref="GeneID:91000622" /db_xref="SGD:S000350095" ORIGIN 1 mnvptaptpn khlnipdlrf ekvfkkalhr elapssslsr kagvitkvvv rdvllmpllq 61 sfvlslalmg vkewlsyirl kgrtlgdrir qrlfpi // LOCUS NP_116694 124 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit CDC26 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116694 VERSION NP_116694.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180001.1 REFERENCE 1 (residues 1 to 124) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 124) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 124) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 124) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12479. Method: conceptual translation. FEATURES Location/Qualifiers source 1..124 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..124 /product="anaphase promoting complex subunit CDC26" /calculated_mol_wt="13950" Region 1..59 /region_name="ANAPC_CDC26" /note="Anaphase-promoting complex APC subunit CDC26; pfam10471" /db_xref="CDD:402205" CDS 1..124 /gene="CDC26" /locus_tag="YFR036W" /gene_synonym="HIT3; SCD26" /coded_by="NM_001180001.1:1..375" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:8895471]" /experiment="EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:12399376]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:8895471]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:8895471]" /note="Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:850597" /db_xref="SGD:S000001932" ORIGIN 1 mirrapttlq lshddvtsli ddlneqklkq qlniektkyf qgknggslhs ntdfqdtsqn 61 iednnndndn didedddmss yndkaasvah trvlnslhls tdsntahets nandnhnpfy 121 iree // LOCUS NP_116695 557 aa linear PLN 30-JUN-2025 DEFINITION Rsc8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116695 VERSION NP_116695.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180002.3 REFERENCE 1 (residues 1 to 557) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 557) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 557) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 557) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12480. On Jul 30, 2012 this sequence version replaced NP_116695.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..557 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..557 /product="Rsc8p" /calculated_mol_wt="63037" Region 26..557 /region_name="RSC8" /note="RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]; COG5259" /db_xref="CDD:227584" CDS 1..557 /gene="RSC8" /locus_tag="YFR037C" /gene_synonym="SWH3" /coded_by="NM_001180002.3:1..1674" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16461455]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15870268]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019|PMID:12183366]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15870268]" /note="Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters" /db_xref="GeneID:850598" /db_xref="SGD:S000001933" ORIGIN 1 msdtekdkdv pmvdsheate eppttstntp sfphlaqeqa keesatlgae vahkkinyeq 61 eaqkleekal rflakqthpv iipsfaswfd iskiheiekr snpdffndss rfktpkaykd 121 trnfiintyr lspyeyltit avrrnvamdv asivkihafl ekwglinyqi dprtkpslig 181 psftghfqvv ldtpqglkpf lpenvikqev eggdgaepqv kkefpvnlti kknvydsaqd 241 fnalqdesrn srqihkvyic htcgnesinv ryhnlrardt nlcsrcfqeg hfganfqssd 301 firlenngns vkknwsdqem llllegiemy edqwekiadh vgghkrvedc iekflslpie 361 dnyirevvgs tlngkggdsr dgsvsgsklm ecvndavqtl lqgddklgkv sdksreisek 421 yieesqaiiq elvkltmekl eskftklcdl etqlemeklk yvkesekmln drlslskqil 481 dlnksleeln vskklvlise qvdsgiqlve kdqegddedg ntatghgvkr vgkegeevge 541 gdsiaklqpq vykpwsl // LOCUS NP_116696 853 aa linear PLN 30-JUN-2025 DEFINITION putative ATPase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116696 VERSION NP_116696.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180003.1 REFERENCE 1 (residues 1 to 853) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 853) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 853) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 853) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12481. On Feb 23, 2004 this sequence version replaced NP_116696.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..853 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..853 /product="putative ATPase" /calculated_mol_wt="96835" Region 74..>767 /region_name="PLN03142" /note="Probable chromatin-remodeling complex ATPase chain; Provisional" /db_xref="CDD:215601" CDS 1..853 /gene="IRC5" /locus_tag="YFR038W" /coded_by="NM_001180003.1:1..2562" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /experiment="EXISTENCE:mutant phenotype:GO:0070987 error-free translesion synthesis [PMID:30111537]" /note="Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and mCherry fusion proteins localize to the nucleus" /db_xref="GeneID:850599" /db_xref="SGD:S000001934" ORIGIN 1 msrcsnaalm tvvedavgar vaartrnmsn gvnyrekevn dltadisdsd sdldsednkh 61 gkgdndtapi wlqddvhsde diqldsedds dteavqaqvv dklakdtkse qkslddelse 121 mdtktvslkl kklnefvrqs qvyssiiadt llhrsnevan antkdnsnsd deehsskkrk 181 tkkksitdff kkqkknedtt tqngapddaa ikqprllknc ilkpyqlegl nwlitlyeng 241 lngilademg lgktvqsial lafiyemdtk gpflvtapls tldnwmnefa kfapdlpvlk 301 yygtngyker saklknffkq hggtgivits yeiilrdtdl imsqnwkfli vdeghrlkni 361 ncrlikelkk intsnrlllt gtplqnnlae lwsllnfimp difadfeifn kwfdfdslnl 421 gsgsnsealn klindelqkn lisnlhtilk pfllrrlkkv vlanilppkr eyiincpmts 481 aqekfykagl ngklkktmfk elikdfftln deyighvsnr sirdfinykl sgnetsntdn 541 kinptllqmd klykknlqme isnkklqnmm mqlrqiidst flfyfpylhp edltletllk 601 tsgklqilqk lipplisegh kvliysqfvn mldliedwcd lnsfatfrid gsvnnetrkd 661 qlekfnsskd khnifllstr aaglginlvg adtvvlfdsd wnpqvdlqam drchrigqes 721 pvivyrlccd ntiehviltr aankrnlerm viqmgkfnnl kklalnegsf lkankagvnv 781 tnkdlvqels mllmsdesni gfenggqken kategqltdk eveeltnrsl eaykanrvvd 841 lphvklfett sgl // LOCUS NP_116697 510 aa linear PLN 30-JUN-2025 DEFINITION Osw7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116697 VERSION NP_116697.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180004.3 REFERENCE 1 (residues 1 to 510) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 510) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 510) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 510) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12482. On Jul 30, 2012 this sequence version replaced NP_116697.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..510 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..510 /product="Osw7p" /calculated_mol_wt="59229" CDS 1..510 /gene="OSW7" /locus_tag="YFR039C" /coded_by="NM_001180004.3:1..1533" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]" /note="Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; may be involved in response to high salt and changes in carbon source; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; deletion mutant has decreased spore survival in Drosophila feces; OSW7 has a paralog, SHE10, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly" /db_xref="GeneID:850600" /db_xref="SGD:S000001935" ORIGIN 1 mkavfkvtta llacvfiary lvcqqnglgs fatdlqpicr htefsvgslf dsklvegsav 61 sdylvgkysq sikplieryp nsslkrimgy fyrfwynifs flrlnelccs lhsklgplln 121 hlriawyylk pytdnvknvl enpfnsstdw mkygsfsadg tltkpifetd setedyedde 181 nenededede deddvgiede nkeyefdgvq dghgnsqlvt aailqdlski iigsnshael 241 etyeaeslkm eyeawikaid skihsamall dseiqsvfea evqnksieit rnlddlnttv 301 neqlvfldsk ikdinctskf dpvqnkikyf desgqvelea yitkssitsi lknykihlld 361 fekslfhsld sfltemakla esirlenvev yeewgdvmis qwsqrmaymd vrglhledqy 421 dpayieenhs nwlrfmelkk kvisernrlv khdldmtlil ewitklkadf qntknniqdt 481 flqrmntadt lfknrelkeq leeefvrqeh // LOCUS NP_116698 1002 aa linear PLN 30-JUN-2025 DEFINITION Sap155p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116698 VERSION NP_116698.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180005.2 REFERENCE 1 (residues 1 to 1002) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1002) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1002) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 1002) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1002) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1002) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1002) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1002) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12483. On Apr 26, 2011 this sequence version replaced NP_116698.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1002 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..1002 /product="Sap155p" /calculated_mol_wt="114872" Region 334..847 /region_name="SAPS" /note="SIT4 phosphatase-associated protein; pfam04499" /db_xref="CDD:398279" CDS 1..1002 /gene="SAP155" /locus_tag="YFR040W" /coded_by="NM_001180005.2:1..3009" /experiment="EXISTENCE:direct assay:GO:1903765 negative regulation of potassium ion export across plasma membrane [PMID:15947196]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8649382]" /experiment="EXISTENCE:mutant phenotype:GO:1903765 negative regulation of potassium ion export across plasma membrane [PMID:15947196]" /note="Protein required for function of the Sit4p protein phosphatase; forms a complex with Sit4p; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p; protein abundance increases in response to DNA replication stress; SAP155 has a paralog, SAP4, that arose from the whole genome duplication" /db_xref="GeneID:850601" /db_xref="SGD:S000001936" ORIGIN 1 msfwpfgqnl nhsninkild eyfhvlhele rinpsvgkai paifnnvqer gtsdsldsip 61 eeyshgdevk targdqksrf ekddqqerye keeeersmns sessttsfss gstsktdlde 121 edisnatapm mvttknldns fiermlvete llnelsrqnk tlldficfgf ffdkktnkkv 181 nnmeylvdql meciskikta ttvdlnnlid yqeqqqldds sqedvyvesd teqeeekedd 241 nnsnnkkrrk rgsssfgndd innnddddda neddesaylt katiiseifs ldiwlisesl 301 vknqsylnki wsiinqpnfn sensplvpif lkinqnlllt rqdqylnfir tersfvddml 361 khvdisllmd fflkiistdk iesptgiiel vydqnliskc lsflnnkesp adiqacvgdf 421 lkaliaisan aplddisigp nsltrqlasp esiaklvdim inqrgaalnt tvsivielir 481 knnsdydqvn lltttikthp psnrdpiylg yllrkfsnhl sdffqiildi endaniplhe 541 nqlhekfkpl gferfkvvel iaellhcsnm glmnskraer iarrrdkvrs qlshhlqdal 601 ndlsieekeq lktkhsptrd tdhdlknnng kidndnndnd desdygdeid esfeipyinm 661 kqniklrtdp tvgdlfkikl ydtrivskim elflthpwnn fwhnvifdii qqifngrmdf 721 synsflvlsl fnlkssyqfm tdivisdekg tdvsrfspvi rdpnfdfkit tdfilrgyqd 781 sykfyelrkm nlgymghivl iaeevvkfsk lykvelispd iqvilqteew qyyseevlne 841 trmmyskilg ggsyiddgng niipqlpdnt tvltpngdas nnneildsdt gssngtsggg 901 qlinveslee qlslstesdl hnklremlin raqedvdnkn tengvfilgp pedknsnsni 961 nntnhnsnns nnndnndnnd ndndntrnyn edadndndyd he // LOCUS NP_116699 295 aa linear PLN 30-JUN-2025 DEFINITION Erj5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116699 VERSION NP_116699.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180006.3 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 295) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12484. On Jul 30, 2012 this sequence version replaced NP_116699.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..295 /product="Erj5p" /calculated_mol_wt="34060" Region 44..105 /region_name="DnaJ" /note="DnaJ domain; pfam00226" /db_xref="CDD:395170" Site order(74..76,82,85..86,89..90) /site_type="other" /note="HSP70 interaction site [polypeptide binding]" /db_xref="CDD:99751" CDS 1..295 /gene="ERJ5" /locus_tag="YFR041C" /coded_by="NM_001180006.3:1..888" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17157937|PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:17157937]" /note="Type I membrane protein with a J domain; required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response" /db_xref="GeneID:850602" /db_xref="SGD:S000001937" ORIGIN 1 mngywkpalv vlglvslsya fttieteifq lqneistkyg pdmnfykflk lpklqnsstk 61 eitknlrkls kkyhpdknpk yrklyerlnl atqilsnssn rkiydyylqn gfpnydfhkg 121 gfyfsrmkpk twfllafiwi vvnigqyiis iiqyrsqrsr ienfisqckq qddtnglgvk 181 qltfkqhekd egkslvvrfs dvyvvepdgs etlispdtld kpsvknclfw ripasvwnmt 241 fgksvgsagk eeiitdskky dgnqtkkgnk vkkgsakkgq kkmelpngkv iysrk // LOCUS NP_116700 200 aa linear PLN 30-JUN-2025 DEFINITION Keg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116700 VERSION NP_116700.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180007.1 REFERENCE 1 (residues 1 to 200) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 200) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 200) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 200) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12485. Method: conceptual translation. FEATURES Location/Qualifiers source 1..200 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..200 /product="Keg1p" /calculated_mol_wt="23424" CDS 1..200 /gene="KEG1" /locus_tag="YFR042W" /coded_by="NM_001180007.1:1..603" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17893149]" /experiment="EXISTENCE:mutant phenotype:GO:0006078 (1->6)-beta-D-glucan biosynthetic process [PMID:17893149]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18439903]" /note="Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability" /db_xref="GeneID:850603" /db_xref="SGD:S000001938" ORIGIN 1 magiklthkl yqyyqlatsf lyaallirwl ilmplvgsrf lpggihefli ylmfyssime 61 viwllrfhgf kygllsrtfl kdlnfiylvs vihfyddyeh alilknasys sfiislslsq 121 aychwcklfk rkgvkertlv wkvntfvtlp ilylsefall llniqvknyh stptldiinr 181 vvllayfpvl ltaykklltk // LOCUS NP_116701 237 aa linear PLN 30-JUN-2025 DEFINITION Irc6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116701 VERSION NP_116701.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180008.3 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 237) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12486. On Jul 30, 2012 this sequence version replaced NP_116701.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..237 /product="Irc6p" /calculated_mol_wt="27748" Region 162..232 /region_name="Adaptin_binding" /note="Alpha and gamma adaptin binding protein p34; pfam10199" /db_xref="CDD:462994" CDS 1..237 /gene="IRC6" /locus_tag="YFR043C" /coded_by="NM_001180008.3:1..714" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:22993212]" /experiment="EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:22993212]" /experiment="EXISTENCE:physical interaction:GO:0016192 vesicle-mediated transport [PMID:22993212]" /note="Clathrin coat accessory factor; involved in clathrin-mediated vesicle trafficking; may function to link the AP-1 clathrin adaptor complex with the Rab GTPase Ypt31p; has structural similarity to G-proteins; mouse homolog Aagab (p34) functionally complements irc6 null mutation; null mutant displays increased levels of spontaneous Rad52p foci" /db_xref="GeneID:850604" /db_xref="SGD:S000001939" ORIGIN 1 mvlqypqnki lvlsdhphnf lktqflqdlf hcsstgisiv kdqtwenryy kvhfdlyids 61 ckeipvwvee fitpeceplr nvmagiilit dirqtkpqel lhqfmiaahr ntfvvlanvn 121 eeveqdeide lneiwsnaft nviefvnwkr skptvnhndy geklgldriq eiidthdwln 181 cevqpatkir eeipnemple qiirnlqsar lkyksienss eadafanema delsryl // LOCUS NP_116702 481 aa linear PLN 30-JUN-2025 DEFINITION metallodipeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_116702 VERSION NP_116702.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180009.1 REFERENCE 1 (residues 1 to 481) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 481) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 481) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 481) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 481) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12487. Method: conceptual translation. FEATURES Location/Qualifiers source 1..481 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..481 /product="metallodipeptidase" /calculated_mol_wt="52740" Region 8..477 /region_name="M20_dipept_like_CNDP" /note="M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase; cd05676" /db_xref="CDD:349925" Site order(102,137,171..172,200,202,215,348,385,419,421..423, 450) /site_type="active" /db_xref="CDD:349925" Site order(106,112,216,218,220,222,228..231,233..243,245,249, 252..253,256..258,292,295..297,300..301,309,312..313, 318..325,329..336,338..339,344,348,373..374,376,385, 420..421,449..452) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:349925" CDS 1..481 /gene="DUG1" /locus_tag="YFR044C" /coded_by="NM_001180009.1:1..1446" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095|PMID:17179087]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0070573 metallodipeptidase activity [PMID:19346245]" /experiment="EXISTENCE:genetic interaction:GO:0008242 omega peptidase activity [PMID:17179087]" /experiment="EXISTENCE:mutant phenotype:GO:0006751 glutathione catabolic process [PMID:17179087]" /experiment="EXISTENCE:mutant phenotype:GO:0070573 metallodipeptidase activity [PMID:19346245]" /note="Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p); human homolog CNDP2 can complement yeast dug1 mutant" /db_xref="GeneID:850605" /db_xref="SGD:S000001940" ORIGIN 1 mshsltsvfq kidslkpqff srltkaiqip avssdeslrs kvfdkakfis eqlsqsgfhd 61 ikmvdlgiqp ppistpnlsl ppvilsrfgs dpskktvlvy ghydvqpaql edgwdtepfk 121 lvideakgim kgrgvtddtg pllswinvvd afkasgqefp vnlvtcfegm eesgslklde 181 likkeangyf kgvdavcisd nywlgtkkpv ltyglrgcny yqtiiegpsa dlhsgifggv 241 vaepmidlmq vlgslvdskg kilidgidem vapltekeka lykdiefsve elnaatgskt 301 slydkkedil mhrwrypsls ihgvegafsa qgaktvipak vfgkfsirtv pdmdseklts 361 lvqkhcdakf kslnspnkcr telihdgayw vsdpfnaqft aakkatklvy gvdpdftreg 421 gsipitltfq dalntsvlll pmgrgddgah sinekldisn fvggmktmaa ylqyysespe 481 n // LOCUS NP_116703 309 aa linear PLN 30-JUN-2025 DEFINITION Mrx20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116703 VERSION NP_116703.5 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180010.3 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 309) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12488. On Jul 30, 2012 this sequence version replaced NP_116703.4. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..309 /product="Mrx20p" /calculated_mol_wt="34260" Region 8..80 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 95..213 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 219..307 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..309 /gene="MRX20" /locus_tag="YFR045W" /coded_by="NM_001180010.3:1..930" /note="Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white" /db_xref="GeneID:850606" /db_xref="SGD:S000001941" ORIGIN 1 manqnsdlyk qitagsvaav fqttmtypfe ylktglqlqp kgtafeiilp qiksyfvgcs 61 alnvaafgkt ilrfvtfdkl chslnnnidn ndnfqrltgy nlliagtltg iveslfiipf 121 enikttliqs amidhkklek nqpvvnakat fhkvatkstp variekllpa vkhmyqtrgp 181 aafvqgttat ifrqiantsi qftaytafkr llqarndkas svitglatsf tlvamtqpid 241 vvktrmmsqn akteykntln cmyrifvqeg matfwkgsif rfmkvgisgg ltftvyeqvs 301 lllgfssrs // LOCUS NP_116704 361 aa linear PLN 30-JUN-2025 DEFINITION centromere-binding protein CNN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116704 VERSION NP_116704.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180011.1 REFERENCE 1 (residues 1 to 361) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 361) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 361) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 361) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12489. Method: conceptual translation. FEATURES Location/Qualifiers source 1..361 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..361 /product="centromere-binding protein CNN1" /calculated_mol_wt="41182" Region 272..361 /region_name="CNN1_HFD" /note="C-terminal histone fold domain of Saccharomyces cerevisiae co-purified with NNF1 protein 1 (CNN1); cd22574" /db_xref="CDD:439341" Site order(274,277,281..282,285..286,289..290,297,300..301, 304..305,308..309,312..313,316,324,328,333,340,343, 347..348,352,355..356,359..360) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:439341" Site order(281,283..284,338,341..342,345..351,353..354,357..358, 361) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:439341" CDS 1..361 /gene="CNN1" /locus_tag="YFR046C" /coded_by="NM_001180011.1:1..1086" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:22561346|PMID:22561345]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:22561345|PMID:22561346]" /experiment="EXISTENCE:mutant phenotype:GO:1905560 negative regulation of kinetochore assembly [PMID:22561345]" /experiment="EXISTENCE:physical interaction:GO:0007059 chromosome segregation [PMID:14633972|PMID:9520439]" /note="Kinetochore protein; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by Clb5-Cdk1, Mps1p, Ipl1p and to a lesser extent by Clb2-Cdk1; localizes to the lower region of the Ndc80 complex during anaphase and regulates KMN activity by inhibiting the Mtw1 and Spc105 complexes from binding to the Ndc80 complex; similar to metazoan CENP-T" /db_xref="GeneID:850607" /db_xref="SGD:S000001942" ORIGIN 1 mstprkaagn nentevseir tpfreralee qrlkdevlir ntpgyrklls astkshdiln 61 kdpnevrsfl qdlsqvlark sqgndtttnk tqarnlidel ayeesqpeen ellrsrsekl 121 tdnnignetq pdytslsqtv faklqerdkg lksrkidpii iqdvpttghe deltvhspdk 181 ansismevlr tspsigmdqv deppvrdpvp isitqqeepl sedlpsddke eteeaenedy 241 sfentsdenl ddigndpirl nvpavrrssi kplqimdlkh ltrqflnenr iilpkqtwst 301 iqeeslnimd flkqkigtlq kqelvdsfid mgiinnvddm felahellpl elqsriesyl 361 f // LOCUS NP_602317 295 aa linear PLN 30-JUN-2025 DEFINITION nicotinate-nucleotide diphosphorylase (carboxylating) [Saccharomyces cerevisiae S288C]. ACCESSION NP_602317 VERSION NP_602317.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180012.3 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 295) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12490. On Jul 30, 2012 this sequence version replaced NP_602317.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..295 /product="nicotinate-nucleotide diphosphorylase (carboxylating)" /EC_number="2.4.2.19" /calculated_mol_wt="32234" Region 17..293 /region_name="nadC" /note="nicotinate-nucleotide pyrophosphorylase; TIGR00078" /db_xref="CDD:272894" CDS 1..295 /gene="BNA6" /locus_tag="YFR047C" /gene_synonym="QPT1" /coded_by="NM_001180012.3:1..888" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan [PMID:12062417]" /experiment="EXISTENCE:mutant phenotype:GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity [PMID:12062417]" /note="Quinolinate phosphoribosyl transferase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p" /db_xref="GeneID:850608" /db_xref="SGD:S000001943" ORIGIN 1 mpvyehllpv ngawrqdvtn wlsedvpsfd fggyvvgsdl keanlyckqd gmlcgvpfaq 61 evfnqcelqv ewlfkegsfl epskndsgki vvakitgpak nillaertal nilsrssgia 121 tashkiisla rstgykgtia gtrkttpglr rlekysmlvg gcdthrydls smvmlkdnhi 181 watgsitnav knaravcgfa vkieveclse deateaieag advimldnfk gdglkmcaqs 241 lknkwngkkh fllecsggln ldnleeylcd didiystssi hqgtpvidfs lklah // LOCUS NP_683716 662 aa linear PLN 30-JUN-2025 DEFINITION Rmd8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_683716 VERSION NP_683716.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180013.1 REFERENCE 1 (residues 1 to 662) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 662) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 662) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 662) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12491. Method: conceptual translation. FEATURES Location/Qualifiers source 1..662 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..662 /product="Rmd8p" /calculated_mol_wt="75783" Region 427..605 /region_name="DUF155" /note="RMND1/Sif2-Sif3/Mrx10, DUF155; pfam02582" /db_xref="CDD:460604" CDS 1..662 /gene="RMD8" /locus_tag="YFR048W" /coded_by="NM_001180013.1:1..1989" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Cytosolic protein required for sporulation" /db_xref="GeneID:850609" /db_xref="SGD:S000001944" ORIGIN 1 msykanqpsp gempkrspsi lvtdartskn rmsapfagha agsrknmena gvtksqgvrs 61 saigpsplqs fthprrrssg rfsdisidni lsdnsdipsa rreerlssss sdrprqyerl 121 ssrrkminpl pprtsktsqk lvlipeddnl nhfqtlptna ldrqrpkvgs mksnsfdrlp 181 ryskeksmar itaynvadgf nlnqlykflq ethevsprly declyvaytl pllpgkggfr 241 iksnlskktm ggktlidnli dtseqrdhhy eyysgvetve dannnyelet sgnnnnanqd 301 tttvpdhlpn pvgqqdsfnp mepqffaeet pleiekrert erinmlkkee ndsdascgnd 361 nnnknndksk lyavegndqy vqssrspasp ssistpspps ssqndfdrvy kmhrdndheg 421 ndrhaeifif hygvivfwnf teiqeknilg ditfadyknl mirpldeqdi eteqfhfeyd 481 rdterprifn divtlrsgdh iieltlshai aqssklsrfe srispilisv tklpkrlaly 541 gtlglkreql lkksgklfkl rvdvnlssti ldtpeffwsf epslhplyva mreyleidqr 601 vqvlndrckv fleffdicvd svaernmarv twwfilvilf gvifslteif vryviihrht 661 st // LOCUS NP_116707 123 aa linear PLN 30-JUN-2025 DEFINITION alpha-ketoglutarate dehydrogenase subunit KGD4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116707 VERSION NP_116707.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180014.3 REFERENCE 1 (residues 1 to 123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 123) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12492. On Jul 30, 2012 this sequence version replaced NP_116707.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..123 /product="alpha-ketoglutarate dehydrogenase subunit KGD4" /calculated_mol_wt="13558" Region 16..122 /region_name="S36_mt" /note="Ribosomal protein S36, mitochondrial; pfam10937" /db_xref="CDD:402493" CDS 1..123 /gene="KGD4" /locus_tag="YFR049W" /gene_synonym="YMR31" /coded_by="NM_001180014.3:1..372" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2693936]" /experiment="EXISTENCE:direct assay:GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity [PMID:25165143]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005761 mitochondrial ribosome [PMID:2693936]" /experiment="EXISTENCE:direct assay:GO:0045252 oxoglutarate dehydrogenase complex [PMID:25165143]" /experiment="EXISTENCE:mutant phenotype:GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity [PMID:25165143]" /experiment="EXISTENCE:mutant phenotype:GO:0006099 tricarboxylic acid cycle [PMID:25165143]" /experiment="EXISTENCE:mutant phenotype:GO:0006103 2-oxoglutarate metabolic process [PMID:25165143]" /note="Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase; recruits E3 subunit (Lpd1p) to the E1-E2 (Kgd1p, Kgd2p) core; exists in two forms derived from a single mRNA translated from two alternative start sites; evolutionarily conserved role in the organization of mitochondrial alpha-KGDH complexes; homolog of human KGD4" /db_xref="GeneID:850610" /db_xref="SGD:S000001945" ORIGIN 1 miatpirlak sayepmikfv gtrhplvkha tevvvhpcat ngmlpgskec ipvskfmeny 61 kpfrvvpikh sanaglsssk tsvfvnrplq kdelasifel parfrykpin ehelesinsg 121 gaw // LOCUS NP_116708 266 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit beta 7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116708 VERSION NP_116708.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180015.1 REFERENCE 1 (residues 1 to 266) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 266) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 266) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 266) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12493. Method: conceptual translation. FEATURES Location/Qualifiers source 1..266 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..266 /product="proteasome core particle subunit beta 7" /calculated_mol_wt="29312" Region 40..236 /region_name="proteasome_beta_type_4" /note="proteasome beta type-4 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03760" /db_xref="CDD:239729" Site order(42,58,60,74,179,221,224..225) /site_type="active" /db_xref="CDD:239729" Site order(60,63,65..70,90,92,106,124,127..128,130..131,134,137, 164,166,168..171,174,182..183,185..186,189..191,212, 219..222,225..226) /site_type="other" /note="beta subunit interaction site [polypeptide binding]" /db_xref="CDD:239729" CDS 1..266 /gene="PRE4" /locus_tag="YFR050C" /coded_by="NM_001180015.1:1..801" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /experiment="EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:17911101]" /note="Beta 7 subunit of the 20S proteasome" /db_xref="GeneID:850611" /db_xref="SGD:S000001946" ORIGIN 1 mnhdpfswgr padstygayn tqianagasp mvntqqpivt gtsvismkyd ngviiaadnl 61 gsygsllrfn gverlipvgd ntvvgisgdi sdmqhierll kdlvtenayd npladaeeal 121 epsyifeyla tvmyqrrskm nplwnaiiva gvqsngdqfl ryvnllgvty ssptlatgfg 181 ahmanpllrk vvdresdipk ttvqvaeeai vnamrvlyyr darssrnfsl aiidkntglt 241 fkknlqvenm kwdfakdikg ygtqki // LOCUS NP_116709 546 aa linear PLN 30-JUN-2025 DEFINITION coatomer subunit delta [Saccharomyces cerevisiae S288C]. ACCESSION NP_116709 VERSION NP_116709.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180016.3 REFERENCE 1 (residues 1 to 546) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 546) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 546) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 546) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12494. On Jul 30, 2012 this sequence version replaced NP_116709.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..546 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..546 /product="coatomer subunit delta" /calculated_mol_wt="60497" Region 4..135 /region_name="Delta_COP_N" /note="delta subunit of the F-COPI complex, N-terminal domain; cd14830" /db_xref="CDD:341434" Region 289..543 /region_name="AP_delta-COPI_MHD" /note="Mu homology domain (MHD) of adaptor protein (AP) coat protein I (COPI) delta subunit; cd09254" /db_xref="CDD:271162" CDS 1..546 /gene="RET2" /locus_tag="YFR051C" /coded_by="NM_001180016.3:1..1641" /experiment="EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:21435344]" /experiment="EXISTENCE:genetic interaction:GO:0048313 Golgi inheritance [PMID:18595704]" /experiment="EXISTENCE:genetic interaction:GO:0090167 Golgi distribution to daughter cells [PMID:18595704]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8617224]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8617224]" /experiment="EXISTENCE:mutant phenotype:GO:0030126 COPI vesicle coat [PMID:8617224]" /note="Delta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" /db_xref="GeneID:850612" /db_xref="SGD:S000001947" ORIGIN 1 mvvlaasitt rqgkpllsrq fkdlskdrvl ellsnfqnlv seissdhtfv edkhvryvyr 61 pfdnyyiili tnrqsniikd latlnlfsqt insylssfqd qeifhnafei lssfdeivsm 121 ggykenlsft qvqtylsmes heeriqeiie rnkeieatee rkrrakeiar keherkhgfm 181 ssngdydgan rfmgskdpnv tnainsyysh aspaaqqsyl qsshaaaaev apvaspmats 241 qraghsatgg mklgggagrr agaaprpsai ssassgtppp peedvpenng ilisikevin 301 aefsrdgtih sselkgvlel rindhdlshs nlkladsidv rdksfqfkth pnidkqsfls 361 tklislrdks kafpandqsl gvlrwrkvap aeddsliplt lttwvspses qqgfdviiey 421 esvletelad viftipvfpq epvdintess tcsdaevvnm dqemgtsiki skiaandaga 481 laftieapye dalypmtvsf qestrdklak sftgmaiqsv vmandhdqel pydvitslks 541 deylvq // LOCUS NP_116710 274 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle lid subunit RPN12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116710 VERSION NP_116710.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180017.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 274) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12495. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..274 /product="proteasome regulatory particle lid subunit RPN12" /calculated_mol_wt="31788" Region 122..226 /region_name="SAC3_GANP" /note="SAC3/GANP family; cl24019" /db_xref="CDD:474128" CDS 1..274 /gene="RPN12" /locus_tag="YFR052W" /gene_synonym="NIN1" /coded_by="NM_001180017.1:1..825" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:9741626]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10490625]" /note="Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850613" /db_xref="SGD:S000001948" ORIGIN 1 mpslaeltks lsiafengdy aacekllppi kieliknnll ipdlsiqndi ylndlmitkr 61 ilevgalasi qtfnfdsfen yfnqlkpyyf snnhklsesd kksklislyl lnllsqnntt 121 kfhselqyld khiknledds llsypikldr wlmegsyqka wdllqsgsqn isefdsftdi 181 lksairdeia kntelsydfl plsnikallf fnneketekf alernwpivn skvyfnnqsk 241 ekadyedemm heedqktnii ekamdyaisi eniv // LOCUS NP_116711 485 aa linear PLN 30-JUN-2025 DEFINITION hexokinase 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116711 VERSION NP_116711.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180018.3 REFERENCE 1 (residues 1 to 485) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 485) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 485) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 485) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 485) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 485) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 485) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 485) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12496. On Jul 30, 2012 this sequence version replaced NP_116711.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..485 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..485 /product="hexokinase 1" /EC_number="2.7.1.1" /calculated_mol_wt="53607" Region 38..471 /region_name="ASKHA_NBD_HK1-2_fungi" /note="nucleotide-binding domain (NBD) of hexokinase isozymes PI and PII from fungal hexokinase (HK) domain family; cd24087" /db_xref="CDD:466937" CDS 1..485 /gene="HXK1" /locus_tag="YFR053C" /coded_by="NM_001180018.3:1..1458" /experiment="EXISTENCE:direct assay:GO:0004396 hexokinase activity [PMID:332086|PMID:12611889]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11254124]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006013 mannose metabolic process [PMID:332086]" /experiment="EXISTENCE:direct assay:GO:0006096 glycolytic process [PMID:332086]" /experiment="EXISTENCE:genetic interaction:GO:0046323 D-glucose import [PMID:6300872]" /experiment="EXISTENCE:genetic interaction:GO:1990539 fructose import across plasma membrane [PMID:6300872]" /experiment="EXISTENCE:mutant phenotype:GO:0004396 hexokinase activity [PMID:6341351]" /experiment="EXISTENCE:mutant phenotype:GO:0006000 fructose metabolic process [PMID:6300872]" /experiment="EXISTENCE:mutant phenotype:GO:0006006 glucose metabolic process [PMID:6300872]" /note="Hexokinase isoenzyme 1; a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves hexokinase Hxk2p; HXK1 has a paralog, HXK2, that arose from the whole genome duplication" /db_xref="GeneID:850614" /db_xref="SGD:S000001949" ORIGIN 1 mvhlgpkkpq arkgsmadvp kelmdeihql edmftvdset lrkvvkhfid elnkgltkkg 61 gnipmipgwv mefptgkesg nylaidlggt nlrvvlvkls gnhtfdttqs kyklphdmrt 121 tkhqeelwsf iadslkdfmv eqellntkdt lplgftfsyp asqnkinegi lqrwtkgfdi 181 pnveghdvvp llqneiskre lpieivalin dtvgtliasy ytdpetkmgv ifgtgvngaf 241 ydvvsdiekl egkladdips nspmaincey gsfdnehlvl prtkydvavd eqsprpgqqa 301 fekmtsgyyl gellrlvlle lnekglmlkd qdlsklkqpy imdtsypari eddpfenled 361 tddifqkdfg vkttlperkl irrlceligt raarlavcgi aaicqkrgyk tghiaadgsv 421 ynkypgfkea aakglrdiyg wtgdaskdpi tivpaedgsg agaaviaals ekriaegksl 481 giiga // LOCUS NP_001335774 192 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFR054C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335774 VERSION NP_001335774.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348833.1 REFERENCE 1 (residues 1 to 192) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 192) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 192) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 192) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80294. Method: conceptual translation. FEATURES Location/Qualifiers source 1..192 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..192 /product="uncharacterized protein" /calculated_mol_wt="20328" CDS 1..192 /locus_tag="YFR054C" /coded_by="NM_001348833.1:1..579" /note="hypothetical protein; conserved among S. cerevisiae strains" /db_xref="GeneID:850615" /db_xref="SGD:S000001950" ORIGIN 1 mlfaysgcla pqcipdissf kalpfrdtes rfttdssvis srfsssftss sskiiiitsi 61 fsskmdnehv gaslivslsm asliltnvfs fsstsyssqp sdyiacspsg iddqpvaeps 121 gytpvgsssp hsgcitsgld aigyqsslne gqstnassrf vtkvyshsal thiilhllsi 181 lqkfylqvst is // LOCUS NP_116714 340 aa linear PLN 30-JUN-2025 DEFINITION cysteine-S-conjugate beta-lyase IRC7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116714 VERSION NP_116714.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180021.1 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 340) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12497. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..340 /product="cysteine-S-conjugate beta-lyase IRC7" /EC_number="4.4.1.13" /calculated_mol_wt="36840" Region 11..340 /region_name="MetC" /note="Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; COG0626" /db_xref="CDD:440391" CDS 1..340 /gene="IRC7" /locus_tag="YFR055W" /coded_by="NM_001180021.1:1..1023" /experiment="EXISTENCE:direct assay:GO:0006790 sulfur compound metabolic process [PMID:21569935]" /experiment="EXISTENCE:direct assay:GO:0019450 L-cysteine catabolic process to pyruvate [PMID:21569935]" /experiment="EXISTENCE:direct assay:GO:0047804 cysteine-S-conjugate beta-lyase activity [PMID:21569935]" /experiment="EXISTENCE:mutant phenotype:GO:0006790 sulfur compound metabolic process [PMID:21569935]" /experiment="EXISTENCE:mutant phenotype:GO:0019450 L-cysteine catabolic process to pyruvate [PMID:21569935]" /experiment="EXISTENCE:mutant phenotype:GO:0047804 cysteine-S-conjugate beta-lyase activity [PMID:21569935]" /note="Cysteine desulphydrase, enables growth on cysteine as nitrogen source; involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner" /db_xref="GeneID:850616" /db_xref="SGD:S000001952" ORIGIN 1 midrtelskf gittqlsvig rnpdeqsgfv npplykgsti ilkklsdleq rkgrfygtag 61 sptidnlena wthltggagt vlsasglgsi slallalska gdhilmtdsv yvptrmlcdg 121 llakfgvetd yydpsigkdi eklvkpnttv iflespgsgt mevqdipalv svakkhgikt 181 ildntwatpl ffdahahgid isveagtkyl gghsdlligl asaneecwpl lrstydamam 241 lpgaedcqla lrgmrtlhlr lkeverkald laawlgnrde vekvlhpafe dcpgheywvr 301 dykgssglfs ivlkngftra glekmvegmk vlqlgfswgg // LOCUS NP_116715 151 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YFR057W [Saccharomyces cerevisiae S288C]. ACCESSION NP_116715 VERSION NP_116715.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180022.3 REFERENCE 1 (residues 1 to 151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 151) AUTHORS Murakami,Y., Naitou,M., Hagiwara,H., Shibata,T., Ozawa,M., Sasanuma,S., Sasanuma,M., Tsuchiya,Y., Soeda,E., Yokoyama,K. et al. TITLE Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae JOURNAL Nat. Genet. 10 (3), 261-268 (1995) PUBMED 7670463 REFERENCE 4 (residues 1 to 151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA12498. On Jul 30, 2012 this sequence version replaced NP_116715.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VI" Protein 1..151 /product="uncharacterized protein" /calculated_mol_wt="17372" CDS 1..151 /locus_tag="YFR057W" /coded_by="NM_001180022.3:1..456" /note="Telomere-linked gene, silencing of which is strictly Sir2-dependent" /db_xref="GeneID:850618" /db_xref="SGD:S000001953" ORIGIN 1 mifgptsvys kcsakssgii kdtaklpisr vrikvmleit vsflffdrfp rsflnhnlyd 61 sicpffawqy tsyylsiyrq sflfhflqkd fsndfvseel iyalvalgak nsfdnslskh 121 tyeyynhskr nlledstnkn safssasvtk p // LOCUS NP_011251 380 aa linear PLN 30-JUN-2025 DEFINITION Cos12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011251 VERSION NP_011251.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181129.1 REFERENCE 1 (residues 1 to 380) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 380) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 380) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 380) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07855. Method: conceptual translation. FEATURES Location/Qualifiers source 1..380 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..380 /product="Cos12p" /calculated_mol_wt="44673" Region 70..164 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 264..354 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..380 /gene="COS12" /locus_tag="YGL263W" /coded_by="NM_001181129.1:1..1143" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /db_xref="GeneID:852628" /db_xref="SGD:S000003232" ORIGIN 1 mdgakfentv aflpseifdc ynstlpknvf rsfvtwscye kfnslefrtw llmwlpliia 61 wkirgkrhyl vivtalmfev lyflwtysyi frertlgkqv sqfakeiitn tpgidtedwe 121 rvavnfnsyl yenklwntey fffdgsscqe afrkmllepf slkkndfana kvpdgsvcyt 181 ekalqvyftq ierkwhwins egflhnkttq svqfskhgyg skllwafkev timnsrfaff 241 siaylngllt iprlrnslhi lyvcavlssm iieyligidk frfksmnlih klqflsyitc 301 gheksdatnw sqiakrtnty mfeqkiwnsp ilfsdgidce kffkwyfstp vssqaslsvg 361 stdfelwpyi keaqsacndv // LOCUS NP_011252 175 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL262W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011252 VERSION NP_011252.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181128.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07856. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..175 /product="uncharacterized protein" /calculated_mol_wt="20000" Region 3..121 /region_name="DUF5341" /note="Family of unknown function (DUF5341); pfam17276" /db_xref="CDD:407389" CDS 1..175 /locus_tag="YGL262W" /coded_by="NM_001181128.1:1..528" /note="hypothetical protein; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene" /db_xref="GeneID:852629" /db_xref="SGD:S000003231" ORIGIN 1 mrnnvtelvn siigvqtpgs lpdtlsgahs lqrrisyfdv nwiswnwdnv nvdlnkevkk 61 srpllgeedd qcmfgwfann pgwkyywsvt dnpdpgyken ysdigdenav hgelyfntyg 121 glmasvmttk mvlnakrqlv vidtivvkai cdyvmkywkk kvnlttisly lmlkl // LOCUS NP_011253 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011253 VERSION NP_011253.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181127.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07857. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..120 /product="seripauperin PAU11" /calculated_mol_wt="12719" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU11" /locus_tag="YGL261C" /coded_by="NM_001181127.1:1..363" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2" /db_xref="GeneID:852630" /db_xref="SGD:S000003230" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ymfqaahpte 61 typvevaeav fnygdfttml tgiapdqvtr mitgvpwyss rlkpaissal skdgiytian // LOCUS NP_011254 76 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL260W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011254 VERSION NP_011254.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181126.1 REFERENCE 1 (residues 1 to 76) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 76) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 76) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 76) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07858. Method: conceptual translation. FEATURES Location/Qualifiers source 1..76 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..76 /product="uncharacterized protein" /calculated_mol_wt="8899" CDS 1..76 /locus_tag="YGL260W" /coded_by="NM_001181126.1:1..231" /note="hypothetical protein; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium" /db_xref="GeneID:852631" /db_xref="SGD:S000003229" ORIGIN 1 memllflnes yifhrlrmws ivlwhscvfv caecgnanyr vprclikpfs vpvtfpfsvk 61 knirildldp rteayc // LOCUS NP_011255 165 aa linear PLN 30-JUN-2025 DEFINITION Yps5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011255 VERSION NP_011255.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181125.1 REFERENCE 1 (residues 1 to 165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 165) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07859. Method: conceptual translation. FEATURES Location/Qualifiers source 1..165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..165 /product="Yps5p" /calculated_mol_wt="17821" Region 65..>100 /region_name="pepsin_retropepsin_like" /note="Cellular and retroviral pepsin-like aspartate proteases; cl11403" /db_xref="CDD:472175" Site order(85,87,89,97..99) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:133137" Site 85..87 /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:133137" Site 85 /site_type="active" /note="Catalytic residue [active]" /db_xref="CDD:133137" CDS 1..165 /gene="YPS5" /locus_tag="YGL259W" /coded_by="NM_001181125.1:1..498" /note="Protein with similarity to GPI-anchored aspartic proteases; such proteases are Yap1p and Yap3p; mCherry fusion protein localizes to the vacuole" /db_xref="GeneID:852632" /db_xref="SGD:S000003228" ORIGIN 1 mqlfsilsll sslmcsltvl gssassyvkf pvqkfadiin igtqdvstvf krnevlnttv 61 ingigvyvvk meigtppqtv ylqldtgssd mivnnadiay cksmsdgsdy astdnyelta 121 tftgprsttt spelitlsal igvnsmqeth lllritrlss mtyty // LOCUS NP_076890 77 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL258W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_076890 VERSION NP_076890.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184473.1 REFERENCE 1 (residues 1 to 77) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 77) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 77) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 77) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07860. Method: conceptual translation. FEATURES Location/Qualifiers source 1..77 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..77 /product="uncharacterized protein" /calculated_mol_wt="8559" Region <6..>74 /region_name="pepsin_retropepsin_like" /note="Cellular and retroviral pepsin-like aspartate proteases; cl11403" /db_xref="CDD:472175" CDS 1..77 /locus_tag="YGL258W-A" /coded_by="NM_001184473.1:1..234" /note="hypothetical protein" /db_xref="GeneID:852633" /db_xref="SGD:S000007607" ORIGIN 1 maferqgkie kkisyslfln gpnvhfgsil fgavdkskya eelcthpmrq ayntldsnsr 61 iiitvqsvai ldgklvw // LOCUS NP_011256 206 aa linear PLN 30-JUN-2025 DEFINITION Vel1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011256 VERSION NP_011256.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181124.1 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07861. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..206 /product="Vel1p" /calculated_mol_wt="22021" Region 6..206 /region_name="Vel1p" /note="Yeast-specific zinc responsive; pfam10339" /db_xref="CDD:402107" CDS 1..206 /gene="VEL1" /locus_tag="YGL258W" /coded_by="NM_001181124.1:1..621" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants; VEL1 has a paralog, YOR387C, that arose from a single-locus duplication" /db_xref="GeneID:852634" /db_xref="SGD:S000003227" ORIGIN 1 msflsiftff svlisvattv rfdltnvtck glhgphcgty vmevvgqngt flgqstfvga 61 dvltesagda warylgqetr flpklttias netknfspli fttnintcnp qsigdamvpf 121 antvtgeiey nswadtadna sfitglanql fnstdygvqv ascypnfasv ilstpavnif 181 gkddtlpdyc taiqlkavcp peagfd // LOCUS NP_011257 558 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,3-mannosyltransferase MNT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011257 VERSION NP_011257.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181123.1 REFERENCE 1 (residues 1 to 558) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 558) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 558) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 558) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07862. Method: conceptual translation. FEATURES Location/Qualifiers source 1..558 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..558 /product="alpha-1,3-mannosyltransferase MNT2" /calculated_mol_wt="64722" Region 174..450 /region_name="Mannosyl_trans3" /note="Mannosyltransferase putative; pfam11051" /db_xref="CDD:402574" CDS 1..558 /gene="MNT2" /locus_tag="YGL257C" /coded_by="NM_001181123.1:1..1677" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:30700649]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000033 alpha-1,3-mannosyltransferase activity [PMID:10521541]" /experiment="EXISTENCE:genetic interaction:GO:0006493 protein O-linked glycosylation [PMID:10521541]" /experiment="EXISTENCE:mutant phenotype:GO:0000033 alpha-1,3-mannosyltransferase activity [PMID:10521541]" /experiment="EXISTENCE:mutant phenotype:GO:0006493 protein O-linked glycosylation [PMID:10521541]" /note="Mannosyltransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans" /db_xref="GeneID:852635" /db_xref="SGD:S000003226" ORIGIN 1 mrrknrlfil vvllgivlvv yysqlnsldl vepvqssssg nggcwsyyeg ltpgwlndfy 61 dvnqitpnpa kdvielvtri kiffnclqqv dghniqrlrd iekklfpyin fekletdesa 121 fwhtttrwng evyhasmlef dpknhqflrs kpinfdtgls fwenwlhtvt qsgskgivis 181 asdvqlneti rllkvlrfik ndypiqivhn adlsqdsmks iikyarsldt aeypaqelwf 241 lnvhsllnpk yskkfttysn kwlaltfssf eipilmdsdt vpfvsiekfy eleefqktgv 301 lffkdrvisd dlfesselki lreivygcig ldledeskih eqvedpvvaq vlenmfikky 361 khhlesglvi lhkgkhlfsm ltsialqfsp iaeyfhgdkd ffwlgellsn nrftfhpvda 421 snigqlgnvv skestgefyq icsvqlshtd rdgsllwlng glnickktsw eydyehrqrl 481 ndmfqnadel reyyaspvkl egiiipdtsi sgwinsgecf lfnyctlfke gefgklikfk 541 edeklrlsqi vdiwnkdi // LOCUS NP_011258 382 aa linear PLN 30-JUN-2025 DEFINITION alcohol dehydrogenase ADH4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011258 VERSION NP_011258.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181122.1 REFERENCE 1 (residues 1 to 382) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 382) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 382) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 382) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07863. On Nov 27, 2009 this sequence version replaced NP_011258.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..382 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..382 /product="alcohol dehydrogenase ADH4" /EC_number="1.1.1.1" /calculated_mol_wt="41011" Region 5..377 /region_name="PDDH" /note="1,3-Propanediol (1,3-PD) dehydrogenase; cd08188" /db_xref="CDD:341467" Site order(40,98..100,103,106,139..140,142,161..162,180,188,195, 199,264,268,278) /site_type="active" /note="putative active site [active]" /db_xref="CDD:341467" Site order(195,199,264,278,282) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:341467" CDS 1..382 /gene="ADH4" /locus_tag="YGL256W" /gene_synonym="NRC465; ZRG5" /coded_by="NM_001181122.1:1..1149" /experiment="EXISTENCE:direct assay:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:3282541]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:17054397|PMID:24769239]" /experiment="EXISTENCE:genetic interaction:GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /experiment="EXISTENCE:mutant phenotype:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:3023838]" /experiment="EXISTENCE:mutant phenotype:GO:0006113 fermentation [PMID:3023838]" /note="Alcohol dehydrogenase isoenzyme type IV; dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency" /db_xref="GeneID:852636" /db_xref="SGD:S000003225" ORIGIN 1 mssvtgfyip pisffgegal eetadyiknk dykkalivtd pgiaaiglsg rvqkmleerd 61 lnvaiydktq pnpnianvta glkvlkeqns eivvsigggs ahdnakaial latnggeigd 121 yegvnqskka alplfaintt agtasemtrf tiisneekki kmaiidnnvt pavavndpst 181 mfglppalta atgldalthc ieayvstasn pitdacalkg idlineslva aykdgkdkka 241 rtdmcyaeyl agmafnnasl gyvhalahql ggfyhlphgv cnavllphvq eanmqcpkak 301 krlgeialhf gasqedpeet ikalhvlnrt mniprnlkel gvktedfeil aehamhdach 361 ltnpvqftke qvvaiikkay ey // LOCUS NP_011259 376 aa linear PLN 30-JUN-2025 DEFINITION high-affinity Zn(2+) transporter ZRT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011259 VERSION NP_011259.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181121.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07864. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..376 /product="high-affinity Zn(2+) transporter ZRT1" /calculated_mol_wt="41451" Region 31..376 /region_name="zip" /note="ZIP zinc/iron transport family; TIGR00820" /db_xref="CDD:273287" CDS 1..376 /gene="ZRT1" /locus_tag="YGL255W" /coded_by="NM_001181121.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000006 high-affinity zinc transmembrane transporter activity [PMID:8637895]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:8637895]" /experiment="EXISTENCE:mutant phenotype:GO:0071578 zinc ion import across plasma membrane [PMID:8637895]" /note="High-affinity zinc transporter of the plasma membrane; responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor" /db_xref="GeneID:852637" /db_xref="SGD:S000003224" ORIGIN 1 msnvttpwwk qwdpsevtla dktpddvwkt cvlqgvyfgg neyngnlgar issvfvilfv 61 stfftmfpli stkvkrlrip lyvylfakyf gsgvivataf ihlmdpayga iggttcvgqt 121 gnwglyswcp aimltsltft fltdlfssvw verkyglshd hthdeikdtv vrntaavsse 181 ndnengtang shdtkngvey yedsdatsmd vvqsfqaqfy aflilefgvi fhsvmiglnl 241 gsvgdefssl ypvlvfhqsf eglgigarls aiefprskrw wpwalcvayg lttpicvaig 301 lgvrtryvsg sytalvisgv ldaisagill ytglvellar dfifnpqrtk dlrelsfnvi 361 ctlfgagima ligkwa // LOCUS NP_011260 299 aa linear PLN 30-JUN-2025 DEFINITION Fzf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011260 VERSION NP_011260.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181120.1 REFERENCE 1 (residues 1 to 299) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 299) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 299) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 299) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07865. Method: conceptual translation. FEATURES Location/Qualifiers source 1..299 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..299 /product="Fzf1p" /calculated_mol_wt="33863" Region 15..297 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 17..36 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(21,23,25,27..28,31..32,35,51,53,57..58,61..62,65,79, 81,83,85..86,89..90,93) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 44..66 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 74..94 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..299 /gene="FZF1" /locus_tag="YGL254W" /gene_synonym="NRC299; RSU1; SUL1" /coded_by="NM_001181120.1:1..900" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10234785]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:35809138|PMID:10234785]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10234785]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:10234785]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10234785]" /experiment="EXISTENCE:mutant phenotype:GO:0018890 cyanamide metabolic process [PMID:35809138]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:35809138|PMID:10870099]" /experiment="EXISTENCE:mutant phenotype:GO:1900072 positive regulation of sulfite transmembrane transport [PMID:10870099]" /note="Transcription factor involved in sulfite metabolism; activates transcription of SSU1, DDI2, DDI3; overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852638" /db_xref="SGD:S000003223" ORIGIN 1 mtdigrtksr nykcsfdgce kvynrpsllq qhqnshtnqk pyhcdepgcg kkfirpchlr 61 vhkwthsqik pkactlcqkr fvtnqqlrrh lnsherkskl asridrkheg vnanvkaeln 121 gkeggfdpkl psgspmcgee fsqghlpgyd dmqvlqcpyk scqkvtsfnd dlinhmlqhh 181 iasklvvpsg dpslkeslpt sekssstdtt sipqlsfstt gtsssesvds ttaqtptdpe 241 sywsdnrckh sdcqelspfa svfdlidhyd hthafipetl vkysyihlyk psvwdlfey // LOCUS NP_011261 486 aa linear PLN 30-JUN-2025 DEFINITION hexokinase 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011261 VERSION NP_011261.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181119.1 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07866. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..486 /product="hexokinase 2" /EC_number="2.7.1.1" /calculated_mol_wt="53812" Region 38..458 /region_name="ASKHA_NBD_HK1-2_fungi" /note="nucleotide-binding domain (NBD) of hexokinase isozymes PI and PII from fungal hexokinase (HK) domain family; cd24087" /db_xref="CDD:466937" CDS 1..486 /gene="HXK2" /locus_tag="YGL253W" /gene_synonym="HEX1; HKB; SCI2" /coded_by="NM_001181119.1:1..1461" /experiment="EXISTENCE:direct assay:GO:0004396 hexokinase activity [PMID:332086|PMID:12611889]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9563516|PMID:37196001|PMID:11311123]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11311123|PMID:9563516]" /experiment="EXISTENCE:direct assay:GO:0006013 mannose metabolic process [PMID:332086]" /experiment="EXISTENCE:direct assay:GO:0006096 glycolytic process [PMID:8917466|PMID:332086]" /experiment="EXISTENCE:direct assay:GO:0046015 regulation of transcription by glucose [PMID:11311123]" /experiment="EXISTENCE:genetic interaction:GO:0046323 D-glucose import [PMID:6300872]" /experiment="EXISTENCE:genetic interaction:GO:1990539 fructose import across plasma membrane [PMID:6300872]" /experiment="EXISTENCE:mutant phenotype:GO:0004396 hexokinase activity [PMID:6341351]" /experiment="EXISTENCE:mutant phenotype:GO:0006000 fructose metabolic process [PMID:6300872]" /experiment="EXISTENCE:mutant phenotype:GO:0006006 glucose metabolic process [PMID:6300872]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:8917466]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0031966 mitochondrial membrane [PMID:31862471]" /experiment="EXISTENCE:mutant phenotype:GO:2001234 negative regulation of apoptotic signaling pathway [PMID:31862471]" /note="Hexokinase isoenzyme 2; phosphorylates glucose in cytosol; predominant hexokinase during growth on glucose; represses expression of HXK1, GLK1, induces expression of its own gene; antiapoptotic; phosphorylation/dephosphorylation at Ser14 by kinase Snf1p, phosphatase Glc7p-Reg1p regulates nucleocytoplasmic shuttling of Hxk2p; functions downstream of Sit4p in control of cell cycle, mitochondrial function, oxidative stress resistance, chronological lifespan; has paralog HXK1" /db_xref="GeneID:852639" /db_xref="SGD:S000003222" ORIGIN 1 mvhlgpkkpq arkgsmadvp kelmqqienf ekiftvptet lqavtkhfis elekglskkg 61 gnipmipgwv mdfptgkesg dflaidlggt nlrvvlvklg gdrtfdttqs kyrlpdamrt 121 tqnpdelwef iadslkafid eqfpqgisep iplgftfsfp asqnkinegi lqrwtkgfdi 181 pnienhdvvp mlqkqitkrn ipievvalin dttgtlvasy ytdpetkmgv ifgtgvngay 241 ydvcsdiekl qgklsddipp sapmaincey gsfdnehvvl prtkyditid eesprpgqqt 301 fekmssgyyl geilrlalmd mykqgfifkn qdlskfdkpf vmdtsypari eedpfenled 361 tddlfqnefg inttvqerkl irrlseliga raarlsvcgi aaicqkrgyk tghiaadgsv 421 ynrypgfkek aanalkdiyg wtqtslddyp ikivpaedgs gagaaviaal aqkriaegks 481 vgiiga // LOCUS NP_011262 588 aa linear PLN 30-JUN-2025 DEFINITION Rtg2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011262 VERSION NP_011262.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181118.1 REFERENCE 1 (residues 1 to 588) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 588) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 588) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 588) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07867. Method: conceptual translation. FEATURES Location/Qualifiers source 1..588 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..588 /product="Rtg2p" /calculated_mol_wt="65441" Region 32..346 /region_name="Ppx-GppA" /note="Ppx/GppA phosphatase family; pfam02541" /db_xref="CDD:396889" CDS 1..588 /gene="RTG2" /locus_tag="YGL252C" /coded_by="NM_001181118.1:1..1767" /experiment="EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:12446794]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10848632]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7493987]" /experiment="EXISTENCE:direct assay:GO:0051219 phosphoprotein binding [PMID:14536080]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7493987]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11687605|PMID:8422683]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:11076970]" /experiment="EXISTENCE:mutant phenotype:GO:0031930 mitochondria-nucleus signaling pathway [PMID:7493987|PMID:8422683]" /experiment="EXISTENCE:mutant phenotype:GO:0034504 protein localization to nucleus [PMID:10848632]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:12399373]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7493987]" /note="Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p" /db_xref="GeneID:852640" /db_xref="SGD:S000003221" ORIGIN 1 mstlsdsdte tevvsrnlcg ivdigsngir fsisskaahh arimpcvfkd rvglslyevq 61 ynthtnakcp iprdiikevc samkrfklic ddfgvpetsv rviateatrd ainadefvna 121 vygstgwkve ilgqedetrv giygvvssfn tvrglyldva ggstqlswvi sshgevkqss 181 kpvslpygag tllrrmrtdd nralfyeike aykdaiekig ipqemiddak keggfdlwtr 241 ggglrgmghl llyqsegypi qtiingyact yeefssmsdy lflkqkipgs skehkifkvs 301 drralqlpav glfmsavfea ipqikavhfs eggvregsly sllpkeiraq dplliasrpy 361 aplltekyly llrtsipqed ipeivneria palcnlafvh asypkelqpt aalhvatrgi 421 iagchglshr araligialc srwggnipes eekysqeleq vvlregdkae alrivwwtky 481 igtimyvicg vhpggnirdn vfdfhvskrs evetslkeli iddanttkvk eestrknrgy 541 evvvriskdd lktsasvrsr iitlqkkvrk lsrgsvervk igvqfyee // LOCUS NP_011263 1187 aa linear PLN 30-JUN-2025 DEFINITION DNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011263 VERSION NP_011263.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181117.1 REFERENCE 1 (residues 1 to 1187) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1187) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1187) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1187) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07868. On Aug 9, 2000 this sequence version replaced NP_011263.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1187 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1187 /product="DNA helicase" /EC_number="3.6.4.12" /calculated_mol_wt="134941" Region 121..653 /region_name="BRR2" /note="Replicative superfamily II helicase [Replication, recombination and repair]; COG1204" /db_xref="CDD:440817" Region 613..953 /region_name="SEC63" /note="Domain of unknown function in Sec63p, Brr2p and other proteins; smart00611" /db_xref="CDD:214744" CDS 1..1187 /gene="HFM1" /locus_tag="YGL251C" /gene_synonym="MER3" /coded_by="NM_001181117.1:1..3564" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:11971962]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11971962]" /experiment="EXISTENCE:direct assay:GO:0006260 DNA replication [PMID:12039965]" /experiment="EXISTENCE:direct assay:GO:0051321 meiotic cell cycle [PMID:11971962]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:15805472]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15066280]" /note="Meiosis specific DNA helicase; involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity" /db_xref="GeneID:852641" /db_xref="SGD:S000003220" ORIGIN 1 mktkfdrlgt gkrsrpspnn idfndqsatf krnkknsrqp sfkvglsyns llddcddene 61 teeifegrgl qffdkddnfs itaddtqvts klfdhdleqt pdeeakkpkk vtirksakkc 121 lsttilpdsf rgvfkftefn kmqseafpsi yesnenciis sptgsgktvl felailrlik 181 etnsdtnntk iiyiaptksl cyemyknwfp sfvnlsvgml tsdtsflete kakkcniiit 241 tpekwdlltr rwsdysrlfe lvklvlvdei htikekrgas leviltrmnt mcqnirfval 301 satvpniedl alwlktnnel panilsfdes yrqvqltkfv ygysfncknd fqkdaiynsk 361 lieiiekhad nrpvlifcpt rastistakf llnnhifsks kkrcnhnpsd kilnecmqqg 421 iafhhagisl edrtavekef lagsinilcs tstlavgvnl paylviikgt kswnsseiqe 481 ysdldvlqmi gragrpqfet hgcavimtds kmkqtyenli hgtdvlessl hlnliehlaa 541 etsletvysi etavnwlrnt ffyvrfgknp aayqevnryv sfhsvedsqi nqfcqylldt 601 lvkvkiidis ngeykstayg namtrhyisf esmkqfinak kflslqgiln llatseefsv 661 mrvrhnekkl fkeinlspll kypfltekkq sqiidrvsqk vslliqyelg glefpsyega 721 sklhqtlvqd kflvfrhcfr llkcmvdtfi eksdgtslkn tlfllrslng hcwentpmvl 781 rqlktiglvs vrrlirhgit nleemghlsd tqieyylnlk igngikiknd isllpclnir 841 tklenckien eelwltfkve isatfkssiw hgqhlsldie tekssgelid frrlqvnklq 901 sprgfrisak ispklekief sihcqeiagl gktivystdh lasqfsaktp nirkdlnsle 961 kclfyesssd gevgktsrvs hkdgleesls sddsildyln erkksskave saavihpeah 1021 ssshfsngrq vrsngnyecf hsckdktqcr hlcckegipv kyikekgpss ikpvskpdqi 1081 rqpllaknin ttphlekrln skpkqwqeen tdiatvhtlp skiynlsqqm ssmeageqvl 1141 ksgpencpei ipidlessds yssntaassi sdpngdldfl gsdiefe // LOCUS NP_011264 241 aa linear PLN 30-JUN-2025 DEFINITION Rmr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011264 VERSION NP_011264.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181116.1 REFERENCE 1 (residues 1 to 241) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 241) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 241) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 241) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07869. On Oct 2, 2003 this sequence version replaced NP_011264.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..241 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..241 /product="Rmr1p" /calculated_mol_wt="27578" Region 84..192 /region_name="DUF2420" /note="Protein of unknown function (DUF2420); pfam10336" /db_xref="CDD:402105" CDS 1..241 /gene="RMR1" /locus_tag="YGL250W" /coded_by="NM_001181116.1:1..726" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006311 meiotic gene conversion [PMID:18069899]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:18069899]" /note="Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus" /db_xref="GeneID:852642" /db_xref="SGD:S000003219" ORIGIN 1 mseeeahktv evddvgvqld egdeedlley ddelveeqps darirnvaet lmkselpkvt 61 veykdttfll ftsddknesn npiicenaal yqrpmgefme sirkfmgnrf grlafatkel 121 vlqlksldlt lfednvynnh isfsdvytif kilkersesn fetdipthla ielstrprfv 181 srynalvelt essatlknik pfsndethpl ivddndqyth qntsevivmd idddvgedse 241 d // LOCUS NP_011265 704 aa linear PLN 30-JUN-2025 DEFINITION Zip2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011265 VERSION NP_011265.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181115.1 REFERENCE 1 (residues 1 to 704) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 704) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 704) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 704) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07870. Method: conceptual translation. FEATURES Location/Qualifiers source 1..704 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..704 /product="Zip2p" /calculated_mol_wt="82685" CDS 1..704 /gene="ZIP2" /locus_tag="YGL249W" /coded_by="NM_001181115.1:1..2115" /experiment="EXISTENCE:direct assay:GO:0000217 DNA secondary structure binding [PMID:30566683]" /experiment="EXISTENCE:direct assay:GO:0000795 synaptonemal complex [PMID:9590170]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:15805472]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:9590170]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15066280]" /experiment="EXISTENCE:mutant phenotype:GO:0033235 positive regulation of protein sumoylation [PMID:23326245]" /note="Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress" /db_xref="GeneID:852643" /db_xref="SGD:S000003218" ORIGIN 1 miierwevkl skcnqnvggy svlsgnlken iklgrraqky lkelrnlqlk plkiggyenc 61 gtingeeyfl evihitsgrq kidvavgktw nvtniendnk eelqyelfke klkvgkqdml 121 ffswmkslsv qlnaplhqkm tehgladdnt rlewfnipll rrsqyrkkvp ypslrqmssv 181 levqcstlte eklnfcvgfs dkplsewkpq ifeqtynryr lqrispeksf kyksrcskyn 241 fktssqswvv kvpehdqqln tfekrydelf daqfnkleff kirmkklkkn kpiekknyki 301 wclekedlkd lvwdplkric nhsryaifeh vtinreaysi kplrltfqkl dsgsldlidn 361 qkktfgsikl amsmpdvkkt enqsieeser hdetaietqe fdendclssk adintslapq 421 krsfidnelm smlvtkkkik kdkdvsdtgi sstsylinsg tyanshieip tsnsvyngke 481 dcsfnnysvk hsileedien kciavnenkv ienqkviqsl cknshldlie qsyfgecdfi 541 inhstcvyki qasrfmqlrn ngslhydkav ndlltefqrv iiivefseii qdvdpdlfwk 601 iklyllnsrv dvffihettd ffidwmkyfi arwafsynde keknianadi lldlgfnill 661 vrkifqtysl eeffmaiike eskavkmltv sqmtrlkkll tlew // LOCUS NP_011266 369 aa linear PLN 30-JUN-2025 DEFINITION 3',5'-cyclic-nucleotide phosphodiesterase PDE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011266 VERSION NP_011266.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181114.1 REFERENCE 1 (residues 1 to 369) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 369) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 369) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 369) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07871. Method: conceptual translation. FEATURES Location/Qualifiers source 1..369 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..369 /product="3',5'-cyclic-nucleotide phosphodiesterase PDE1" /EC_number="3.1.4.17" /calculated_mol_wt="41885" Site order(13,128,130,132..133,244,294,326) /site_type="active" /db_xref="CDD:293821" Region 36..364 /region_name="PDEase_II" /note="cAMP phosphodiesterases class-II; pfam02112" /db_xref="CDD:396610" CDS 1..369 /gene="PDE1" /locus_tag="YGL248W" /coded_by="NM_001181114.1:1..1110" /experiment="EXISTENCE:genetic interaction:GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity [PMID:2824992]" /experiment="EXISTENCE:mutant phenotype:GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity [PMID:6300049|PMID:2824992]" /experiment="EXISTENCE:mutant phenotype:GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway [PMID:9880329]" /note="Low-affinity cyclic AMP phosphodiesterase; controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation" /db_xref="GeneID:852644" /db_xref="SGD:S000003217" ORIGIN 1 mvvfeitilg anggpteygt qcfilkpart edpeliavdg gagmyqlrem lvqgrneneg 61 ddelvpsfye hdrepieffi dsklniqkgl sksllqslkr qgehfesant mkktyevfqg 121 itdyyithph ldhisglvvn spsiyeqens kkktiwglph tidvlqkhvf ndliwpdlta 181 ersrklklkc lnpkevqkct ifpwdvipfk vhhgigvktg apvystfyif rdrkskdcii 241 vcgdveqdrr eseeslleef wsyvaenipl vhlkgilvec scplsskpeq lyghlspiyl 301 inelsnlntl ynsskglsgl nvivthvkst pakrdprlti leelrflaee rnlgdlrisi 361 aleghtlfl // LOCUS NP_011267 197 aa linear PLN 30-JUN-2025 DEFINITION Brr6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011267 VERSION NP_011267.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181113.1 REFERENCE 1 (residues 1 to 197) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 197) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 197) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07872. Method: conceptual translation. FEATURES Location/Qualifiers source 1..197 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..197 /product="Brr6p" /calculated_mol_wt="22676" Region 1..197 /region_name="Brr6_like_C_C" /note="Di-sulfide bridge nucleocytoplasmic transport domain; cl12377" /db_xref="CDD:448450" CDS 1..197 /gene="BRR6" /locus_tag="YGL247W" /coded_by="NM_001181113.1:1..594" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:30133335]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:26432634|PMID:11483521]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0055088 lipid homeostasis [PMID:20016074|PMID:26432634]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:30133335]" /experiment="EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:20016074]" /experiment="EXISTENCE:mutant phenotype:GO:0055088 lipid homeostasis [PMID:26432634|PMID:20016074]" /note="Essential nuclear envelope integral membrane protein; interacts with chromatin, helping to maintain normal chromatin architecture and transcriptional regulation of certain loci at the nuclear envelope; interacts and functions with Apq12p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA nuclear export, and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; homologous to Brl1p" /db_xref="GeneID:852645" /db_xref="SGD:S000003216" ORIGIN 1 melrsfsrqp dgilanprlg reevlegehp qdarlarqsi wlspsliaey iqlffnfiig 61 tiglslaikf ilmirndvnl klehnvreel dkiatcksry fenqcephmr vpalevrcne 121 wskcmnkeiv sgsdyqwaka wartlaevin affeafsirs flfilisiig iifvtntsfg 181 syrvylnnkd tksvrha // LOCUS NP_011268 387 aa linear PLN 30-JUN-2025 DEFINITION decapping nuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_011268 VERSION NP_011268.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181112.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07873. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..387 /product="decapping nuclease" /calculated_mol_wt="44379" Region 222..289 /region_name="RAI1" /note="RAI1 like PD-(D/E)XK nuclease; pfam08652" /db_xref="CDD:462550" CDS 1..387 /gene="RAI1" /locus_tag="YGL246C" /coded_by="NM_001181112.1:1..1164" /experiment="EXISTENCE:direct assay:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:26638174]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12612077|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:10805743]" /experiment="EXISTENCE:direct assay:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:20802481]" /experiment="EXISTENCE:direct assay:GO:0034353 mRNA 5'-diphosphatase activity [PMID:20802481]" /experiment="EXISTENCE:direct assay:GO:1990174 phosphodiesterase decapping endonuclease activity [PMID:20802481]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10805743]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10805743]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:20802481]" /experiment="EXISTENCE:mutant phenotype:GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled [PMID:15565157]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16131592]" /experiment="EXISTENCE:mutant phenotype:GO:0110155 NAD-cap decapping [PMID:33139726]" /experiment="EXISTENCE:mutant phenotype:GO:1990174 phosphodiesterase decapping endonuclease activity [PMID:20802481]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:10805743]" /note="Nuclear decapping endonuclease; targets mRNAs with unmethylated 7-methylguanosine cap structures and 5'-triphosphates; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; involved in an early step of decapping non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs), part of ncRNA surveillance; relocalizes to the cytosol in response to hypoxia; homologous to human DOM3Z" /db_xref="GeneID:852646" /db_xref="SGD:S000003215" ORIGIN 1 mgvsanlfvk qrgsttalkq pkeigfysrt kdeeylisdd tnlnyyylpd aeldrkldls 61 sgfqkfkdyy kdfedrcslr glletiesse rhkgkkinad iitfrgiark liscafdsps 121 fntvdlrivs fngqlfikev peavnaakas sateagrnin qdlnvftgyk fetlatlsnp 181 lqytprevie krtkrivshg deyisvvrtg vgncklilga evdcifdfke ngrdnlkhya 241 elkctqqvan isdthkferk lfrtwlqcfl vgipriiygf kddhyvlktv eefsteevpv 301 llknnnpqvg sacleaikwy glltewllkm iprdedphsq irafklvfen nhlrlseiee 361 sdeeysglid gehilsngfk ewrkslk // LOCUS NP_011269 708 aa linear PLN 30-JUN-2025 DEFINITION glutamate--tRNA ligase GUS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011269 VERSION NP_011269.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181111.1 REFERENCE 1 (residues 1 to 708) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 708) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 708) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 708) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07874. On Oct 2, 2003 this sequence version replaced NP_011269.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..708 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..708 /product="glutamate--tRNA ligase GUS1" /EC_number="6.1.1.17" /calculated_mol_wt="80712" Region 72..>128 /region_name="GST_C_family" /note="C-terminal, alpha helical domain of the Glutathione S-transferase family; cl02776" /db_xref="CDD:470672" Site order(72,79,119,122..123,126) /site_type="other" /note="N-terminal domain interface [polypeptide binding]" /db_xref="CDD:198286" Site order(72..73,76..77,80,100) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:198286" Site order(79,82..83,127) /site_type="other" /note="substrate binding pocket (H-site) [chemical binding]" /db_xref="CDD:198286" Region 102..696 /region_name="gltX_arch" /note="glutamyl-tRNA synthetase, archaeal and eukaryotic family; TIGR00463" /db_xref="CDD:273091" CDS 1..708 /gene="GUS1" /locus_tag="YGL245W" /gene_synonym="GSN1" /coded_by="NM_001181111.1:1..2127" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004818 glutamate-tRNA ligase activity [PMID:11069915]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19417106]" /experiment="EXISTENCE:direct assay:GO:0006424 glutamyl-tRNA aminoacylation [PMID:11069915]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26359986|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0017102 methionyl glutamyl tRNA synthetase complex [PMID:11069915]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852606" /db_xref="SGD:S000003214" ORIGIN 1 mpstltingk apivayaeli aarivnalap nsiaiklvdd kkapaakldd atedvfnkit 61 skfaaifdng dkeqvakwvn laqkelvikn faklsqslet ldsqlnlrtf ilgglkysaa 121 dvacwgalrs ngmcgsiikn kvdvnvsrwy tllemdpifg eahdflsksl lelkksanvg 181 kkkethkanf eidlpdakmg evvtrfppep sgylhighak aallnqyfaq aykgkliirf 241 ddtnpskeke efqdsiledl dllgikgdri tyssdyfqem ydycvqmikd gkaycddtpt 301 ekmreermdg vasarrdrsv eenlriftee mkngteeglk ncvrakidyk alnktlrdpv 361 iyrcnltphh rtgstwkiyp tydfcvpivd aiegvthalr tieyrdrnaq ydwmlqalrl 421 rkvhiwdfar infvrtllsk rklqwmvdkd lvgnwddprf ptvrgvrrrg mtveglrnfv 481 lsqgpsrnvi nlewnliwaf nkkvidpiap rhtaivnpvk ihlegseapq epkiemkpkh 541 kknpavgekk viyykdivvd kddadvinvd eevtlmdwgn viitkknddg smvaklnleg 601 dfkktkhklt wladtkdvvp vdlvdfdhli tkdrleedes fedfltpqte fhtdaiadln 661 vkdmkigdii qferkgyyrl dalpkdgkpy vfftipdgks vnkygakk // LOCUS NP_011270 558 aa linear PLN 30-JUN-2025 DEFINITION RNA polymerase-associated protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011270 VERSION NP_011270.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181110.1 REFERENCE 1 (residues 1 to 558) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 558) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 558) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 558) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07875. Method: conceptual translation. FEATURES Location/Qualifiers source 1..558 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..558 /product="RNA polymerase-associated protein" /calculated_mol_wt="65738" Region 1..558 /region_name="COG5296" /note="Transcription factor involved in TATA site selection and in elongation by RNA polymerase II [Transcription]" /db_xref="CDD:227615" CDS 1..558 /gene="RTF1" /locus_tag="YGL244W" /gene_synonym="CSL3" /coded_by="NM_001181110.1:1..1677" /experiment="EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:12682017]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:20732871]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15643076]" /experiment="EXISTENCE:direct assay:GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding [PMID:22796944]" /experiment="EXISTENCE:direct assay:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:20299458]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11884586]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:11927560]" /experiment="EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:21737840]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15180994]" /experiment="EXISTENCE:mutant phenotype:GO:0001015 snoRNA transcription by RNA polymerase II [PMID:16246725]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:11927560]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:15149594]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:16246725]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:14710186]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:32290544]" /experiment="EXISTENCE:mutant phenotype:GO:0070911 global genome nucleotide-excision repair [PMID:21737840]" /experiment="EXISTENCE:physical interaction:GO:0016593 Cdc73/Paf1 complex [PMID:11884586|PMID:11927560]" /note="Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay" /db_xref="GeneID:852607" /db_xref="SGD:S000003213" ORIGIN 1 msdldedlla lagadeseee dqvltttsak raknndqsls kkrrievgsv edddeeddyn 61 pysvgnadyg seeeeeanpf plegkykdes drehleslpe meretllfer sqimqkyqer 121 klfrargrdm keqqqraknd edsrktrast rsthatghsd ikasklsqlk kqrarknrhy 181 sdnededdee dyreedykdd egseygddee ynpfdrrdty dkreevewae eedeqdrepe 241 isdfnklrig rsfvakfcfy pgfedavkgc ygrvnvgtdk rtgktsyrmv riervflqkp 301 ynmgkfytnq yfgvtqgkdr kvfqmnyfsd glfaedeyqr ylraldnsqm ikpslhslsn 361 ktkevmdfvn tpltdkttde vvrhrmqfnk klsgtnavle ktvlreklqy aketnnekdi 421 akysaqlrnf ekrmsvyekh hendqsdikk lgeltsknrk lnmsnirnae hvkkedsnnf 481 dsksdpfsrl ktrtkvyyqe iqkeenakak eiaqqeklqe dkdakdkrek ellvaqfrrl 541 gglermvgel dikfdlkf // LOCUS NP_011271 400 aa linear PLN 30-JUN-2025 DEFINITION tRNA-specific adenosine deaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011271 VERSION NP_011271.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181109.1 REFERENCE 1 (residues 1 to 400) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 400) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 400) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 400) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07876. Method: conceptual translation. FEATURES Location/Qualifiers source 1..400 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..400 /product="tRNA-specific adenosine deaminase" /EC_number="3.5.4.34" /calculated_mol_wt="45816" Region 22..400 /region_name="ADEAMc" /note="tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase); smart00552" /db_xref="CDD:214718" CDS 1..400 /gene="TAD1" /locus_tag="YGL243W" /coded_by="NM_001181109.1:1..1203" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:9707437]" /experiment="EXISTENCE:direct assay:GO:0043829 tRNA-specific adenosine-37 deaminase activity [PMID:9707437]" /note="tRNA-specific adenosine deaminase; deaminates adenosine-37 to inosine in tRNA-Ala" /db_xref="GeneID:852608" /db_xref="SGD:S000003212" ORIGIN 1 mvscqgtrpc ivnlltmpse dklgeeistr vineysklks acrpiirpsg irewtilagv 61 aainrdggan kieilsiatg vkalpdselq rsegkilhdc haeilalrga ntvllnriqn 121 ynpssgdkfi qhndeiparf nlkenwelal yisrlpcgda smsflndnck nddfikieds 181 defqyvdrsv ktilrgrlnf nrrnvvrtkp grydsnitls kscsdkllmk qrssvlncln 241 yelfekpvfl kyivipnled etkhhleqsf htrlpnldne ikflnclkpf yddkldeedv 301 pglmcsvklf mddfsteeai lngvrngfyt ksskplrkhc qsqvsrfaqw elfkkirpey 361 egisylefks rqkkrsqlii aiknilspdg wiptrtddvk // LOCUS NP_011272 181 aa linear PLN 30-JUN-2025 DEFINITION ankyrin repeat-containing protein ANK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011272 VERSION NP_011272.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181108.1 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07877. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..181 /product="ankyrin repeat-containing protein ANK1" /calculated_mol_wt="19943" Region 12..122 /region_name="Ank_2" /note="Ankyrin repeats (3 copies); pfam12796" /db_xref="CDD:463710" Region 12..47 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(13..14,17..19,21..22,26,29,47,49,51,55..56,59..61, 63..64,68,71,83,85,87,91..92,95..97,99..100,110,113,122) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 49..83 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 85..122 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..181 /gene="ANK1" /locus_tag="YGL242C" /coded_by="NM_001181108.1:1..546" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:37531259]" /note="Cytoplasmic ankyrin repeat-containing protein; co-purifies with Myo3p and Myo5p by large-scale affinity capture; localization of the long-tailed type I myosins is altered in the null mutant; N-terminally propionylated in vivo; contains three ankyrin repeats and an acidic tail; orthologous to human OSTF1" /db_xref="GeneID:852609" /db_xref="SGD:S000003211" ORIGIN 1 mntegaslse qlldaarrnn ldlletvfds ldndpekiak lineskeplg ntalhlccky 61 gswevldkil dqdgeieidp qndvdgdtpl hvtvrysqee pehgtfiarn lievgadprv 121 rnynnqkpvd lvhgdeldel idllqgaela idstngsgdn nedgemiddg psdddeeddk 181 k // LOCUS NP_011273 1004 aa linear PLN 30-JUN-2025 DEFINITION karyopherin KAP114 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011273 VERSION NP_011273.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181107.1 REFERENCE 1 (residues 1 to 1004) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1004) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1004) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1004) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1004) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1004) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1004) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1004) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07878. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1004 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1004 /product="karyopherin KAP114" /calculated_mol_wt="113791" Region 10..>165 /region_name="CSE1" /note="CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; COG5657" /db_xref="CDD:227944" CDS 1..1004 /gene="KAP114" /locus_tag="YGL241W" /coded_by="NM_001181107.1:1..3015" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10385521|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:10385521]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:15888545]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:10385521|PMID:15888545]" /experiment="EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:12456659]" /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:10385521]" /experiment="EXISTENCE:physical interaction:GO:0061608 nuclear import signal receptor activity [PMID:10385521]" /note="Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852610" /db_xref="SGD:S000003210" ORIGIN 1 mdineliiga qsadkhtrev aetqllqwcd sdasqvfkal anvalqheas lesrqfalls 61 lrklitmyws pgfesyrsts nveidvkdfi revllklcln dnentkikng asycivqisa 121 vdfpdqwpql ltviydaish qhslnamsll neiyddvvse emffeggigl atmeivfkvl 181 ntetstliak iaalkllkac llqmsshney deasrksfvs qclatslqil gqlltlnfgn 241 vdvisqlkfk siiyenlvfi kndfsrkhfs selqkqfkim aiqdlenvth inanvettes 301 eplletvhdc siyiveflts vctlqfsvee mnkiitslti lcqlssetre iwtsdfntfv 361 sketglaasy nvrdqaneff tslpnpqlsl ifkvvsndie hstcnystle sllyllqcil 421 lnddeitgen idqslqilik tlenilvsqe ipelilarai ltiprvldkf idalpdikpl 481 tsaflaksln lalksdkeli ksatliafty ycyfaeldsv lgpevcsetq ekviriinqv 541 ssdaeedtng almevlsqvi synpkephsr keilqaefhl vftissedpa nvqvvvqsqe 601 cleklldnin mdnyknyiel clpsfinvld snnannyrys pllslvlefi tvflkkkpnd 661 gflpdeinqy lfeplakvla fstedetlql ateafsylif ntdtramepr lmdimkvler 721 llslevsdsa amnvgplvva iftrfskeiq pligrileav vvrliktqni steqnllsvl 781 cfltcndpkq tvdflssfqi dntdaltlvm rkwieafevi rgekrikeni valsnlffln 841 dkrlqkvvvn gnlipyegdl iitrsmakkm pdryvqvply tkiiklfvse lsfqskqpnp 901 eqlitsdikq evvnankddd nddwedvddv ldydklkeyi dddvdeeadd dsdditglmd 961 vkesvvqllv rffkevaskd vsgfhciyet lsdserkvls eall // LOCUS NP_011274 250 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit DOC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011274 VERSION NP_011274.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181106.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07879. On Oct 2, 2003 this sequence version replaced NP_011274.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..250 /product="anaphase promoting complex subunit DOC1" /calculated_mol_wt="28646" Region 59..248 /region_name="DOC1" /note="Anaphase-promoting complex (APC), subunit 10 [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones]; COG5156" /db_xref="CDD:227485" Site order(112,139,146,148,213) /site_type="other" /note="putative ligand binding site [chemical binding]" /db_xref="CDD:176484" CDS 1..250 /gene="DOC1" /locus_tag="YGL240W" /gene_synonym="APC10" /coded_by="NM_001181106.1:1..753" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:12402045]" /experiment="EXISTENCE:direct assay:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:12402045]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:12402045]" /experiment="EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:12399376]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:12402045|PMID:9348530]" /note="Processivity factor; required for ubiquitination activity of anaphase promoting complex (APC), mediates the activity of APC by contributing to substrate recognition; involved in cyclin proteolysis; contains conserved DOC1 homology domain" /db_xref="GeneID:852611" /db_xref="SGD:S000003209" ORIGIN 1 mdpiginkvl dhlapselik pvkschnkps vlvlddrivd aatkdlyvng fqeeiqyqnp 61 tpenlqhmfh qgieildsar minvthlalw kpssfklgnp vdfalddnyd tfwqsdggqp 121 hqldimfskr mdicvmaiff smiadesyap slvkvyaghs psdarfykml evrnvngwva 181 lrfldnredd qllkcqfirl lfpvnhengk dthlrgirly vpsnephqdt hewaqtlpet 241 nnvfqdailr // LOCUS NP_011276 960 aa linear PLN 30-JUN-2025 DEFINITION importin-alpha export receptor [Saccharomyces cerevisiae S288C]. ACCESSION NP_011276 VERSION NP_011276.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181104.1 REFERENCE 1 (residues 1 to 960) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 960) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 960) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 960) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 960) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 960) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 960) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 960) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07880. Method: conceptual translation. FEATURES Location/Qualifiers source 1..960 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..960 /product="importin-alpha export receptor" /calculated_mol_wt="109226" Region 1..960 /region_name="CSE1" /note="CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; COG5657" /db_xref="CDD:227944" CDS 1..960 /gene="CSE1" /locus_tag="YGL238W" /gene_synonym="KAP109" /coded_by="NM_001181104.1:1..2883" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:9857050]" /experiment="EXISTENCE:genetic interaction:GO:0005049 nuclear export signal receptor activity [PMID:9857050]" /experiment="EXISTENCE:genetic interaction:GO:0006611 protein export from nucleus [PMID:9857050]" /experiment="EXISTENCE:mutant phenotype:GO:0061015 snRNA import into nucleus [PMID:31189105]" /experiment="EXISTENCE:physical interaction:GO:0005049 nuclear export signal receptor activity [PMID:9857050]" /experiment="EXISTENCE:physical interaction:GO:0006611 protein export from nucleus [PMID:9857050]" /note="Nuclear envelope protein that acts as a recycling factor; mediates the nuclear export of Srp1p (importin alpha) back to the cytoplasm after its import substrates have been released into the nucleoplasm, thereby allowing the participation of Srp1p in multiple rounds of nuclear import; required for accurate chromosome segregation; homolog of metazoan CAS and human CSE1L, overexpression of which is implicated in cancer progression" /db_xref="GeneID:852612" /db_xref="SGD:S000003207" ORIGIN 1 msdletvakf laesviasta ktsernlrql etqdgfgltl lhviastnlp lstrlagalf 61 fknfikrkwv dengnhllpa nnvelikkei vplmislpnn lqvqigeais siadsdfpdr 121 wptllsdlas rlsnddmvtn kgvltvahsi fkrwrplfrs delfleiklv ldvftapfln 181 llktvdeqit anennkasln ilfdvllvli klyydfncqd ipeffedniq vgmgifhkyl 241 sysnplledp detehasvli kvkssiqelv qlyttryedv fgpminefiq itwnlltsis 301 nqpkydilvs kslsfltavt ripkyfeifn nesamnnite qiilpnvtlr eedvelfedd 361 pieyirrdle gsdtdtrrra ctdflkelke knevlvtnif lahmkgfvdq ymsdpsknwk 421 fkdlyiylft alaingnitn agvsstnnll nvvdfftkei apdltsnnip hiilrvdaik 481 yiytfrnqlt kaqlielmpi latflqtdey vvytyaaiti ekiltiresn tspafifhke 541 disnsteill knlialilkh gsspeklaen eflmrsifrv lqtsedsiqp lfpqllaqfi 601 eivtimaknp snprfthytf esigailnyt qrqnlpllvd smmptfltvf sediqefipy 661 vfqiiafvve qsatipesik plaqpllapn vwelkgnipa vtrllksfik tdssifpdlv 721 pvlgifqrli askayevhgf dllehimlli dmnrlrpyik qiavlllqrl qnskteryvk 781 kltvffglis nklgsdflih fidevqdglf qqiwgnfiit tlptignlld rkialigvln 841 mvingqffqs kyptlisstm nsiietassq sianlkndyv dldnleeist fgshfsklvs 901 isekpfdplp eidvnngvrl yvaealnkyn aisgntflnt ilpqltqenq vklnqllvgn // LOCUS NP_011277 265 aa linear PLN 30-JUN-2025 DEFINITION transcription activator HAP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011277 VERSION NP_011277.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181103.1 REFERENCE 1 (residues 1 to 265) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 265) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 265) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 265) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07881. Method: conceptual translation. FEATURES Location/Qualifiers source 1..265 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..265 /product="transcription activator HAP2" /calculated_mol_wt="29736" Region 1..263 /region_name="HAP2" /note="CCAAT-binding factor, subunit B [Transcription]; COG5224" /db_xref="CDD:227549" CDS 1..265 /gene="HAP2" /locus_tag="YGL237C" /coded_by="NM_001181103.1:1..798" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:7828851]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:2832951]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0016602 CCAAT-binding factor complex [PMID:2832951]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2832951]" /experiment="EXISTENCE:mutant phenotype:GO:0043457 regulation of cellular respiration [PMID:2182199]" /experiment="EXISTENCE:physical interaction:GO:0016602 CCAAT-binding factor complex [PMID:2832951]" /note="Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose-repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding; respiratory defect of the null mutant is functionally complemented by human NFYA" /db_xref="GeneID:852614" /db_xref="SGD:S000003206" ORIGIN 1 msadetdakf hpletdlqsd taaatstaaa srspslqekp iempldmgka psprgedqrv 61 tneedlflfn rlrasqnrvm dslepqqqsq ytsssvstme psadftsfsa vttlpppphq 121 qqqqqqqqqq qqqlvvqaqy tqnqpnlqsd vlgtaiaeqp fyvnakqyyr ilkrryarak 181 leeklrisre rkpylhesrh khamrrprge ggrfltaaei kamkskksga sddpddshed 241 kkittkiiqe qphatstaaa adkkt // LOCUS NP_011278 669 aa linear PLN 30-JUN-2025 DEFINITION tRNA modification protein MTO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011278 VERSION NP_011278.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181102.1 REFERENCE 1 (residues 1 to 669) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 669) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 669) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 669) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07882. On Jul 26, 2004 this sequence version replaced NP_011278.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..669 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..669 /product="tRNA modification protein MTO1" /calculated_mol_wt="74085" Region 37..665 /region_name="gidA" /note="glucose-inhibited division protein A; TIGR00136" /db_xref="CDD:272927" CDS 1..669 /gene="MTO1" /locus_tag="YGL236C" /gene_synonym="IPS1" /coded_by="NM_001181102.1:1..2010" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9774408|PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0070899 mitochondrial tRNA wobble uridine modification [PMID:15509579]" /note="Mitochondrial protein; forms heterodimer complex with Mss1p that performs 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants; human homolog MTO1 can complement yeast null mutant" /db_xref="GeneID:852616" /db_xref="SGD:S000003205" ORIGIN 1 mlrvttlass ctsfplqvlr rrltisslts fqpttktqvv vigaghagce aaaassrtga 61 httlitpslt digkcscnps iggvgkgilv keidaldglm gkvtdlagvq fkmlnrskgp 121 avwgpraqid relykkymqr elsdkkahpn lsllqnkvad lilydpgcgh kvikgvvldd 181 gtqvgadqvi ittgtflsae ihigdkriaa grigeqptyg isntlqnevg fqlgrlktgt 241 parlakesid fsalevqkgd alpvpmsfln etvsveptkq ldcfgthttp qmhdflrnnl 301 hqsihiqdtt ikgprycpsi eakilrfpdr sshkiwlepe gfnsdviypn gisnsmpedv 361 qlqmmrlipg manveilqpa ygveydyvdp rqlkpsletk lvdglflagq ingttgyeea 421 aaqgiiagin agllsrqere qlvlkrseay igvliddlin ngviepyrmf tsrsefrisv 481 radnadfrlt pigaqlgiis pvrlsqysrd khlydetira lqnfklssqk wssllqania 541 pqaenrsawe ifrfkdmdlh klyecipdlp inlldipmhv vtkiniqgky epyivkqnqf 601 vkafqadenm llpqdydyrq lptlsteckl llnrvqplti gqarriqgit aaalfelyrv 661 arkpsqpvm // LOCUS NP_011279 178 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL235W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011279 VERSION NP_011279.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181101.1 REFERENCE 1 (residues 1 to 178) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 178) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 178) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 178) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07883. Method: conceptual translation. FEATURES Location/Qualifiers source 1..178 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..178 /product="uncharacterized protein" /calculated_mol_wt="19203" CDS 1..178 /locus_tag="YGL235W" /coded_by="NM_001181101.1:1..537" /note="hypothetical protein; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2" /db_xref="GeneID:852615" /db_xref="SGD:S000003204" ORIGIN 1 mtlwphpgsy kiksatlfcs rdklgcafls esslcmyfly nslsiwalgp htagplllfs 61 ilnctparsv tlpispsras isftrmplpt ppieglhehl pisvndgvmr vvcapvldda 121 aaasqpacpa pmtttcvlvv gwklvkedmv nrllrtckgn evhedakvvt rsivlwgv // LOCUS NP_011280 802 aa linear PLN 30-JUN-2025 DEFINITION bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011280 VERSION NP_011280.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181100.1 REFERENCE 1 (residues 1 to 802) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 802) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 802) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 802) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07884. Method: conceptual translation. FEATURES Location/Qualifiers source 1..802 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..802 /product="bifunctional aminoimidazole ribotide synthase/glycinamide ribotide synthase" /EC_number="6.3.3.1" /EC_number="6.3.4.13" /calculated_mol_wt="85937" Region 2..441 /region_name="purD" /note="phosphoribosylamine--glycine ligase; TIGR00877" /db_xref="CDD:273315" Region 450..786 /region_name="purM" /note="phosphoribosylaminoimidazole synthetase; TIGR00878" /db_xref="CDD:273316" CDS 1..802 /gene="ADE57" /locus_tag="YGL234W" /coded_by="NM_001181100.1:1..2409" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /note="Bifunctional enzyme of 'de novo' purine nucleotide pathway; contains both phosphoribosylglycinamidine synthetase/glycinamide ribotide synthetase (EC 6.3.4.13) ['Ade5'] and phosphoribosylaminoimidazole synthetase/aminoimidazole ribotide synthetase (EC 6.3.3.1) ['Ade7'] activities" /db_xref="GeneID:852617" /db_xref="SGD:S000003203" ORIGIN 1 mlnilvlgng arehvlvtkl aqsptvgkiy vapgnggtat mdpsrvinwd itpdvanfar 61 lqsmavehki nlvvpgpelp lvngitsvfh svgipvfgps vkaaqleask afskrfmskh 121 niptasydvf tnpeeaisfl qahtdkafvi kadgiaagkg viipssides vqaikdimvt 181 kqfgeeagkq vvieqflegd eislltivdg yshfnlpvaq dhkrifdgdk glntggmgay 241 apapvatpsl lktidsqivk ptidgmrrdg mpfvgvlftg milvkdsktn qlvpevleyn 301 vrfgdpetqa vlsllddqtd laqvflaaae hrldsvnigi ddtrsavtvv vaaggypesy 361 akgdkitldt dklpphtqif qagtkydsat dslltnggrv lsvtstaqdl rtavdtvyea 421 vkcvhfqnsy yrkdiayraf qnsesskvai tyadsgvsvd ngnnlvqtik emvrstrrpg 481 adsdiggfgg lfdlaqagfr qnedtllvga tdgvgtklii aqetgihntv gidlvamnvn 541 dlvvqgaepl ffldyfatga ldiqvasdfv sgvangciqs gcalvggets empgmyppgh 601 ydtngtavga vlrqdilpki nemaagdvll glassgvhsn gfslvrkiiq hvalpwdapc 661 pwdesktlge gileptkiyv kqllpsirqr lllglahitg gglvenipra ipdhlqarvd 721 mstwevprvf kwfgqagnvp hddilrtfnm gvgmvlivkr envkavcdsl teegeiiwel 781 gslqerpkda pgcviengtk ly // LOCUS NP_011281 910 aa linear PLN 30-JUN-2025 DEFINITION Rab GTPase-binding exocyst subunit SEC15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011281 VERSION NP_011281.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181099.1 REFERENCE 1 (residues 1 to 910) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 910) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 910) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 910) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07885. Method: conceptual translation. FEATURES Location/Qualifiers source 1..910 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..910 /product="Rab GTPase-binding exocyst subunit SEC15" /calculated_mol_wt="104933" Region 521..864 /region_name="Sec15" /note="Exocyst complex subunit Sec15-like; pfam04091" /db_xref="CDD:461169" CDS 1..910 /gene="SEC15" /locus_tag="YGL233W" /coded_by="NM_001181099.1:1..2733" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:16478783]" /experiment="EXISTENCE:direct assay:GO:0000145 exocyst [PMID:8978675|PMID:1512289|PMID:7615633]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:16478783]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:16478783]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:10022848]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:6996832]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /note="Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase" /db_xref="GeneID:852618" /db_xref="SGD:S000003202" ORIGIN 1 mdqegqplls kdfqqvllat asgnnsswte ravlnnestd avkhepalgq ndvfdldpls 61 fdkwvpflrr aldknqldpv idelensied nfqglelqll qdsqmndkle tsideianiq 121 gmvqdtlsse iskfqirlse sanelivkkq myvnnkkisl kiseatilit kvvrilelss 181 kcqeliterk ffkvlqnlds leklylqefk nynfqfliei ynsipflqkv tkdecinlir 241 nslnlnlgkn likvgqefva iyenellpqw letrskmklt nfkfnspiei smrdesflak 301 lnlgeffqld dfhdsimifq nlnelsvlsg efnkeyelrk tklmypliwk knktaayqmd 361 sllrgtgttp gstahdvstd dpftqslslh flqdyflkil gfllydinln katefilvdn 421 nynstnefwd glmdrlspyl syfideklkt eedmiklkdf lciyvailen fklnieplyk 481 ilvsifekfc svslrafdde fqillndddf mplsindktl yekvlkicwm kegehlslpd 541 ptngepfavt lpfsplypmt ctlakktysk itaflsifyr helhtlnnil vktmddifnd 601 ivnkkirskl estsreeiaq ilvnldyfii aakefsnfmt renilqnpdm eirlssikyl 661 aesrklaetk lielidskis diletieidw qitevrqdpd isiidlaqfl emmfastlqn 721 lpysvqtlli frefdsltrq fmglllhdtp stithesimn fevdvnyles iiprifpstp 781 gtidsngyqs pmtpstptfp nangvdaptl fennikslea tfmelkqcie llktqgkdyn 841 epeirlrkys rirqedaall lskiqhfvss vegangddts vmdsssifns esasvidsnt 901 sriakffnrr // LOCUS NP_011282 289 aa linear PLN 30-JUN-2025 DEFINITION putative tRNA acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011282 VERSION NP_011282.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181098.1 REFERENCE 1 (residues 1 to 289) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 289) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 289) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 289) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07886. Method: conceptual translation. FEATURES Location/Qualifiers source 1..289 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..289 /product="putative tRNA acetyltransferase" /calculated_mol_wt="33419" Region 113..259 /region_name="THUMP_THUMPD1_like" /note="THUMP domain-containing protein 1-like; cd11717" /db_xref="CDD:212586" CDS 1..289 /gene="TAN1" /locus_tag="YGL232W" /coded_by="NM_001181098.1:1..870" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:15037780]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:15037780]" /note="Adaptor in Kre33p-mediated N4-acetylcytidine modification of tRNAs; tRNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine (ac4C) in serine and leucine tRNAs but not required for the same modification in 18S rRNA; protein abundance increases in response to DNA replication stress; contains a conserved THUMP domain, and is homologous to human THUMPD1" /db_xref="GeneID:852619" /db_xref="SGD:S000003201" ORIGIN 1 mgekrnrngk dansqnrkkf kvssgfldpg tsgiyatcsr rherqaaqel qllfeekfqe 61 lygdikeged esendekkdl siedqikkel qelkgeetgk dlssgetkkk dplafidlnc 121 ecvtfcktrk pivpeefvls imkdladpkn mvkrtryvqk ltpityscna kmeqliklan 181 lvigphfhdp snvkknykfa vevtrrnfnt iermdiinqv vklvnkegse fnhtvdlkny 241 dklilvecfk snigmcvvdg dyktkyrkyn vqqlyeskfr kdedksvkq // LOCUS NP_011283 190 aa linear PLN 30-JUN-2025 DEFINITION chaperone EMC4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011283 VERSION NP_011283.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181097.1 REFERENCE 1 (residues 1 to 190) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 190) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 190) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 190) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07887. Method: conceptual translation. FEATURES Location/Qualifiers source 1..190 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..190 /product="chaperone EMC4" /calculated_mol_wt="21329" Region 60..176 /region_name="DUF1077" /note="Protein of unknown function (DUF1077); pfam06417" /db_xref="CDD:461902" CDS 1..190 /gene="EMC4" /locus_tag="YGL231C" /coded_by="NM_001181097.1:1..573" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0072546 EMC complex [PMID:19325107]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]" /note="Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm ZK616.6/EMC-4 and fly CG11137; mutation is functionally complemented by human EMC4" /db_xref="GeneID:852620" /db_xref="SGD:S000003200" ORIGIN 1 mseqepyewa khlldtkyie kyniqnsntl psppgfegns skgnvtrkqq datsqttsla 61 qknqitvlqv qkawqialqp aksipmnifm symsgtslqi ipimtalmll sgpikaifst 121 rsafkpvlgn katqsqvqta mfmyivfqgv lmyigyrkln smglipnakg dwlpweriah 181 ynnglqwfsd // LOCUS NP_011284 147 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL230C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011284 VERSION NP_011284.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181096.1 REFERENCE 1 (residues 1 to 147) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 147) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 147) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 147) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07888. Method: conceptual translation. FEATURES Location/Qualifiers source 1..147 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..147 /product="uncharacterized protein" /calculated_mol_wt="17131" CDS 1..147 /locus_tag="YGL230C" /coded_by="NM_001181096.1:1..444" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; non-essential gene" /db_xref="GeneID:852621" /db_xref="SGD:S000003199" ORIGIN 1 mgiitlsgnv lhllkaypkk gleevsqpep ntandsstey kgkskddfqm veksntdery 61 nftrtkkwfl lmtseyyklm enrllmfcii acsficaiqf lffiiywtni vprktqrait 121 nlnydyltah lkeqcvpyak ildqcil // LOCUS NP_011285 818 aa linear PLN 30-JUN-2025 DEFINITION Sap4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011285 VERSION NP_011285.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181095.1 REFERENCE 1 (residues 1 to 818) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 818) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 818) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 818) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07889. Method: conceptual translation. FEATURES Location/Qualifiers source 1..818 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..818 /product="Sap4p" /calculated_mol_wt="94598" Region 207..736 /region_name="SAPS" /note="SIT4 phosphatase-associated protein; pfam04499" /db_xref="CDD:398279" CDS 1..818 /gene="SAP4" /locus_tag="YGL229C" /coded_by="NM_001181095.1:1..2457" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8649382]" /note="Protein required for function of the Sit4p protein phosphatase; member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p; SAP4 has a paralog, SAP155, that arose from the whole genome duplication" /db_xref="GeneID:852622" /db_xref="SGD:S000003198" ORIGIN 1 mslwpfgetl shsgidsile eyylifrsle gnetsstddk knepsmeses efgtesrdrs 61 dlnqsfidri lletalldel ngaandrlvd ficlgyfydd rsqqvrhmdy lvdmlmaylk 121 didrtgyrtp fllensfhqt geyedqdded pmlyvniiss ifcsksapiv ealvqntpfl 181 sslfevfqfe nieaencpil avflkinetl lfeqtssyle ffksqpnivd kflyhievsp 241 lveflikiml tdqvesptni idflyhqdli pkclnllens kyspgiqnss gellkalisi 301 stnfkldtlw igpnrltrql aspqyvdqli niilfqrgha mgvavsiiie lirknnsdyd 361 evdllsttiv dnppsqrdpv ylghllyelt mhmedfyall iklenddddd hdtaskalps 421 vkhhllenql hesfrplgfe rvkitelise mlhcsnmglm nskrgekiar trdkcrdtld 481 qnslekamkn lnindntits ntledkcnnn dsndsndnqk qkknikkkfh dnelystfdt 541 sddniddddd msfeipyvse tqnlkirknp tigdlfkikl hdlgffpkfl qlflrypwnn 601 fwhnivfdii qqifngrmdf synsflvysl fdfkkstrfi pkplygsnqk lpvkdfhiis 661 dfilqghkds fefyekektn lgymgqlvli aeeiakyski yktdliapdi yaflqdevwm 721 syssdilnet rtmcsiilgg gqfcaesden tnqdflekad mskpahpstm deneivheed 781 vklhdkvael idelgqltel dihdkikdvi vdhhsdln // LOCUS NP_011286 577 aa linear PLN 30-JUN-2025 DEFINITION She10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011286 VERSION NP_011286.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181094.1 REFERENCE 1 (residues 1 to 577) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 577) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 577) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 577) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07890. Method: conceptual translation. FEATURES Location/Qualifiers source 1..577 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..577 /product="She10p" /calculated_mol_wt="66732" CDS 1..577 /gene="SHE10" /locus_tag="YGL228W" /coded_by="NM_001181094.1:1..1734" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]" /note="Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; putative GPI-anchored protein; overexpression causes growth arrest; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; SHE10 has a paralog, OSW7/YFR039C, that arose from the whole genome duplication; paralogs are redundant for spore wall dityrosine assembly" /db_xref="GeneID:852623" /db_xref="SGD:S000003197" ORIGIN 1 mgkliklitt ltvlvsllqy ccefnsgsis certqtlchy tnprvwntyf srncelyknk 61 vspgfdivar kydtavkpvi ddatvkvnkv aiqpafkvih sqckkwncgk yyqlvrspmv 121 ktrrfffaky nafvkpnldk fftaefrshl kerilkykni ghyyftitsr cikskydfiv 181 gnteeklmgk fknkdthgih gsvtrepsse dmvltvstme sdeeelttts tqtvvetitl 241 dqeeasavan hahddeastd vegstdvnvn eqallqedfd mwsetilqkt qdviqlfekd 301 vskyingklv eeanhfkakf qslddkskkf fskislaind iecvegidse tgkkiffdks 361 gsteisqyit relvreyfne trstldeltn amekdlseit deiekkvnai reenvevfee 421 wgdiivnews krmayvdvin ahmgadddtt ldeekakssv nwkkflkgkk qiiesrdkla 481 hhsadlsrvn afrqkvqkki lsftqesgef lyilrskanl qfqererker erkerekaaa 541 eefqrqqell rqqeeedeed vsytststit ttitmtl // LOCUS NP_011287 958 aa linear PLN 30-JUN-2025 DEFINITION glucose-induced degradation complex subunit VID30 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011287 VERSION NP_011287.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181093.1 REFERENCE 1 (residues 1 to 958) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 958) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 958) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 958) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07891. Method: conceptual translation. FEATURES Location/Qualifiers source 1..958 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..958 /product="glucose-induced degradation complex subunit VID30" /calculated_mol_wt="108048" Region 386..588 /region_name="SPRY_RanBP_like" /note="SPRY domain in Ran binding proteins, SSH4, HECT E3 and SPRYD3; cd12885" /db_xref="CDD:293943" Region 769..826 /region_name="CTLH" /note="C-terminal to LisH motif; smart00668" /db_xref="CDD:128914" Region 828..935 /region_name="CRA" /note="CT11-RanBPM; smart00757" /db_xref="CDD:214806" CDS 1..958 /gene="VID30" /locus_tag="YGL227W" /gene_synonym="GID1" /coded_by="NM_001181093.1:1..2877" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0034657 GID complex [PMID:18508925|PMID:16872538]" /experiment="EXISTENCE:mutant phenotype:GO:0006808 regulation of nitrogen utilization [PMID:11356843]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:15358789|PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]" /note="Central component of GID Complex, involved in FBPase degradation; interacts strongly with Gid8p to serve as a scaffold for other GID Complex subunits; contains SPRY domain and 3 domains that are also found in Gid8p - LisH, CTLH, and CRA; required for association of Vid vesicles and actin patches in vacuole import and degradation pathway; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm" /db_xref="GeneID:852624" /db_xref="SGD:S000003196" ORIGIN 1 mseymddvdr efinclfpsy llqqpvaydl wilylqhrkl fhklkntnli nadenptgvg 61 mgrtkltalt rkeiwsklmn lgvlgtisfe avnddyliqv ykyfypdvnd ftlrfgvkds 121 nknsvrvmka ssdmrknaqe llepvlsere malnsntsle ndrndddddd dddddddddd 181 dddddesdle slegevdtdt ddnnegdgsd nheeggeegs rgadadvssa qqraervadp 241 wiyqrsrsai nietesrnlw dtsdknsglq yyppdqspss sfssprvssg ndkndneatn 301 vlsnsgskkk nsmipdiyki lgyflpsrwq aqpnnslqls qdgithlqpn pdyhsymtye 361 rssassastr nrlrtsfens gkvdfavtwa nkslpdnklt ifyyeikvls vtstesaens 421 nivigyklve nelmeattkk svsrssvags ssslggsnnm ssnrvpstsf tmegtqrrdy 481 iyeggvsams lnvdgsinkc qkygfdlnvf gycgfdglit nsteqskeya kpfgrddvig 541 cginfidgsi fftkngihlg naftdlndle fvpyvalrpg nsiktnfgln edfvfdiigy 601 qdkwkslaye hicrgrqmdv sieefdsdes eedetengpe enkstnvned lmdidqedga 661 agnkdtkkln dekdnnlkfl lgednrfidg klvrpdvnni nnlsvddgsl pntlnvmind 721 yliheglvdv akgflkdlqk davnvngqhs eskdvirhne rqimkeermv kirqelryli 781 nkgqiskcin yidneipdll knnlelvfel klanylvmik kssskdddei enlilkgqel 841 snefiydtki pqslrdrfsg qlsnvsalla ysnplveapk eisgylsdey lqerlfqvsn 901 ntiltflhkd secalenvis ntramlstll eynafgstns sdpryykain fdedvlnl // LOCUS NP_011288 86 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-diphosphooligosaccharide--protein glycotransferase subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_011288 VERSION NP_011288.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181091.1 REFERENCE 1 (residues 1 to 86) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 86) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 86) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 86) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07892. Method: conceptual translation. FEATURES Location/Qualifiers source 1..86 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..86 /product="dolichyl-diphosphooligosaccharide--protein glycotransferase subunit" /calculated_mol_wt="9386" Region 16..86 /region_name="Ost5" /note="Oligosaccharyltransferase subunit 5; pfam05251" /db_xref="CDD:461602" CDS 1..86 /gene="OST5" /locus_tag="YGL226C-A" /coded_by="NM_001181091.1:1..261" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12805367]" /experiment="EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:12805367|PMID:10358084]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9135133]" /experiment="EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]" /experiment="EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]" /note="Zeta subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins" /db_xref="GeneID:852625" /db_xref="SGD:S000003194" ORIGIN 1 mtyeqlykef hssksfqpfi hldtqpkfai cglivtlavl ssalfavgsk ssyikklffy 61 tilsvigslf aglttvfasn sfgvyv // LOCUS NP_011289 123 aa linear PLN 30-JUN-2025 DEFINITION Mtc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011289 VERSION NP_011289.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181092.1 REFERENCE 1 (residues 1 to 123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 123) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07893. Method: conceptual translation. FEATURES Location/Qualifiers source 1..123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..123 /product="Mtc3p" /calculated_mol_wt="14357" Region 25..>109 /region_name="Cyt_c_Oxidase_IV" /note="Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cl02792" /db_xref="CDD:470676" Site order(27,29,31..34,51,53,55,63,67..68,70..71,73..76,79) /site_type="other" /note="Subunit IV/Va interface [polypeptide binding]" /db_xref="CDD:238462" Site order(29,80,82..83) /site_type="other" /note="putative ATP/ADP binding site [chemical binding]" /db_xref="CDD:238462" CDS 1..123 /gene="MTC3" /locus_tag="YGL226W" /coded_by="NM_001181092.1:1..372" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1" /db_xref="GeneID:852626" /db_xref="SGD:S000003195" ORIGIN 1 mmgrngirla lkrsfstyqp pvveitnitk lwptlrpevr deikeylrwr mqedwrhipl 61 eetkaayfls ygpcggrskg newnvgytgm rivfnlvlfg gaatafynwk qdkkleeqlr 121 dlv // LOCUS NP_011290 337 aa linear PLN 30-JUN-2025 DEFINITION GDP-mannose transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_011290 VERSION NP_011290.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181090.1 REFERENCE 1 (residues 1 to 337) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 337) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 337) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 337) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07894. Method: conceptual translation. FEATURES Location/Qualifiers source 1..337 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..337 /product="GDP-mannose transporter" /calculated_mol_wt="36888" Region 15..337 /region_name="VRG4" /note="Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; COG5070" /db_xref="CDD:227402" CDS 1..337 /gene="VRG4" /locus_tag="YGL225W" /gene_synonym="GOG5; LDB3; VAN2; VIG4" /coded_by="NM_001181090.1:1..1014" /experiment="EXISTENCE:direct assay:GO:0005458 GDP-mannose transmembrane transporter activity [PMID:20576760]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:9395539]" /experiment="EXISTENCE:mutant phenotype:GO:0005458 GDP-mannose transmembrane transporter activity [PMID:9395539]" /experiment="EXISTENCE:mutant phenotype:GO:1990570 GDP-mannose transmembrane transport [PMID:9395539]" /note="Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi; VRG4 has a paralog, HVG1, that arose from the whole genome duplication" /db_xref="GeneID:852647" /db_xref="SGD:S000003193" ORIGIN 1 mselktghag hnpwasvans gpisilsycg ssilmtvtnk fvvnlkdfnm nfvmlfvqsl 61 vctitliilr ilgyakfrsl nktdaknwfp isfllvlmiy tsskalqyla vpiytifknl 121 tiiliaygev lffggsvtsm elssfllmvl ssvvatwgdq qavaakaasl aegaagavas 181 fnpgyfwmft ncitsalfvl imrkrikltn fkdfdtmfyn nvlalpilll fsfcvedwss 241 vnltnnfsnd sltamiisgv asvgisycsg wcvrvtsstt ysmvgalnkl pialsgliff 301 daprnflsil sifigflsgi iyavakqkkq qaqplrk // LOCUS NP_011291 280 aa linear PLN 30-JUN-2025 DEFINITION nucleotidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011291 VERSION NP_011291.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181089.1 REFERENCE 1 (residues 1 to 280) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 280) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 280) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 280) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07895. Method: conceptual translation. FEATURES Location/Qualifiers source 1..280 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..280 /product="nucleotidase" /calculated_mol_wt="31838" Region 56..246 /region_name="Pyr-5-nucltdase" /note="pyrimidine 5'-nucleotidase; TIGR01993" /db_xref="CDD:273917" Site order(61..65,77,104,109,165..167,202,227..228,231..232) /site_type="active" /db_xref="CDD:319791" CDS 1..280 /gene="SDT1" /locus_tag="YGL224C" /gene_synonym="SSM1" /coded_by="NM_001181089.1:1..843" /experiment="EXISTENCE:direct assay:GO:0008252 nucleotidase activity [PMID:11934891]" /experiment="EXISTENCE:mutant phenotype:GO:0006206 pyrimidine nucleobase metabolic process [PMID:11934891]" /note="Pyrimidine nucleotidase; responsible for production of nicotinamide riboside and nicotinic acid riboside; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives; SDT1 has a paralog, PHM8, that arose from the whole genome duplication" /db_xref="GeneID:852648" /db_xref="SGD:S000003192" ORIGIN 1 mtveytasdl atyqnevneq iaknkahles lthpgskvtf pidqdisatp qnpnlkvfff 61 didnclykss trihdlmqqs ilrffqthlk lspedahvln nsyykeygla irglvmfhkv 121 naleynrlvd dslplqdilk pdiplrnmll rlrqsgkidk lwlftnaykn hairclrllg 181 iadlfdglty cdysrtdtlv ckphvkafek amkesglary enayfiddsg knietgiklg 241 mktcihlven evneilgqtp egaivisdil elphvvsdlf // LOCUS NP_011292 417 aa linear PLN 30-JUN-2025 DEFINITION Golgi transport complex subunit COG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011292 VERSION NP_011292.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181088.1 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07896. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..417 /product="Golgi transport complex subunit COG1" /calculated_mol_wt="48206" CDS 1..417 /gene="COG1" /locus_tag="YGL223C" /gene_synonym="COD3; LDB11; SEC36" /coded_by="NM_001181088.1:1..1254" /experiment="EXISTENCE:mutant phenotype:GO:0000301 retrograde transport, vesicle recycling within Golgi [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0007030 Golgi organization [PMID:15932880]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:15932880]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /note="Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" /db_xref="GeneID:852649" /db_xref="SGD:S000003191" ORIGIN 1 mdevlplfrd shipqikdyq lelqndltkt neafqknllk nynkilsltd svndlslnlk 61 nvdqdfkslc fndekfqlnk ltplpyqttt hispprdeek vsipsqnilv isnwtisinn 121 fcnrivtstt psrifdelll nfhelslipv pskfealvkd kccrlqkflv dsmktlnltl 181 lqwvklynll ntefsskwdd dllsifnesl fetlfndnvq allissansk dhqyhsnqqy 241 kdaivvdfvn sstfrdhlir rtvkeinthl dtlstlrakl kepetlhkld ifhdndtnln 301 dgtvsplddd alkqyidtav fyskgltndt tlqiyqtvqp tieilqnlel ykcpqetltd 361 lrnklitqlq efktqissrl psplenstsv vddfitsynn hnllqlvidq itqlrqq // LOCUS NP_011293 175 aa linear PLN 30-JUN-2025 DEFINITION Edc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011293 VERSION NP_011293.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181087.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07897. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..175 /product="Edc1p" /calculated_mol_wt="19106" CDS 1..175 /gene="EDC1" /locus_tag="YGL222C" /coded_by="NM_001181087.1:1..528" /experiment="EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:12554867]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:12554867]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19682251]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:19682251]" /experiment="EXISTENCE:direct assay:GO:0098745 RNA decapping complex [PMID:11139489]" /experiment="EXISTENCE:mutant phenotype:GO:0032056 positive regulation of translation in response to stress [PMID:19682251]" /experiment="EXISTENCE:physical interaction:GO:0098745 RNA decapping complex [PMID:11139489]" /note="RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog, EDC2, that arose from the whole genome duplication" /db_xref="GeneID:852650" /db_xref="SGD:S000003190" ORIGIN 1 mstdtmyfns srllpsagrn ktnnlikqkt rnnrargnaa knannnnyit dipppqtlpn 61 gqkpnfghss nkkpsfnqkk hsppsspsst ttlgkknrqn nketprqnnk ddtrllsqnl 121 knlllnqkqs phgsqgiipm gcngsakkls hsyagstfat ngpreaknlp kpsfl // LOCUS NP_011294 288 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL221C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011294 VERSION NP_011294.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181086.1 REFERENCE 1 (residues 1 to 288) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 288) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 288) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 288) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07898. Method: conceptual translation. FEATURES Location/Qualifiers source 1..288 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..288 /product="uncharacterized protein" /calculated_mol_wt="31757" Region 8..284 /region_name="YbgI_SA1388" /note="dinuclear metal center protein, YbgI/SA1388 family; TIGR00486" /db_xref="CDD:213534" CDS 1..288 /gene="NIF3" /locus_tag="YGL221C" /coded_by="NM_001181086.1:1..867" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:17034789]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:17034789|PMID:14562095]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:852651" /db_xref="SGD:S000003189" ORIGIN 1 msraitraql dklvrsitkf ypqkyadksw dntgllidcs taqvttadan aktkvlltvd 61 ltksvaqeav dancnvivay hpfifpswnr lsphtnpqhe taikliqygi svycphtavd 121 aarggvndwl vrglnngenv aksyaletvs getddligyg rfvefnkdis leqivknvkr 181 vlrvpyvqva slaapsawnq lkikkvavca gsgsgvfkql kedvdlyytg emshhevlkw 241 kemgktvivc nhsntergfl qdvmkgllqd eghevvvskm dcdpltva // LOCUS NP_011295 120 aa linear PLN 30-JUN-2025 DEFINITION Bol2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011295 VERSION NP_011295.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181085.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07899. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..120 /product="Bol2p" /calculated_mol_wt="13971" Region 56..114 /region_name="BolA" /note="BolA-like protein; pfam01722" /db_xref="CDD:460305" CDS 1..120 /gene="BOL2" /locus_tag="YGL220W" /gene_synonym="AIM15; FRA2" /coded_by="NM_001181085.1:1..363" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18281282]" /experiment="EXISTENCE:direct assay:GO:0051536 iron-sulfur cluster binding [PMID:31493153]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18281282]" /experiment="EXISTENCE:mutant phenotype:GO:0071281 cellular response to iron ion [PMID:18281282]" /note="Cytosolic protein involved in repression of iron regulon transcription; forms an iron-independent complex with Fra1p, Grx3p, and Grx4p; null mutant fails to repress the iron regulon and is sensitive to nickel; sequence similarity to human BOLA family member, BOLA2" /db_xref="GeneID:852652" /db_xref="SGD:S000003188" ORIGIN 1 mtgeriekvk indefakshf lttqwretkr qrhykmpvte qglreriesa ipqvyhiivt 61 dlsygcgqsf divvvsdffq gksklmrsra vnkavkeelq eihafsckcy teeewskivv // LOCUS NP_011296 459 aa linear PLN 30-JUN-2025 DEFINITION ERMES complex subunit MDM34 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011296 VERSION NP_011296.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181084.1 REFERENCE 1 (residues 1 to 459) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 459) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 459) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 459) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07900. Method: conceptual translation. FEATURES Location/Qualifiers source 1..459 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..459 /product="ERMES complex subunit MDM34" /calculated_mol_wt="51859" Region 1..189 /region_name="SMP_Mdm34" /note="synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in mitochondrial distribution and morphology protein 34 (Mdm34) and similar proteins; cd21673" /db_xref="CDD:439229" Site order(15,18..19,23,27,49,53,75,81,83,85,126,128,132,134, 141,143,145,154,173,176..177,182,184..187) /site_type="other" /note="putative lipid binding site [chemical binding]" /db_xref="CDD:439229" CDS 1..459 /gene="MDM34" /locus_tag="YGL219C" /gene_synonym="MMM2" /coded_by="NM_001181084.1:1..1380" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:14981098]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:37366411]" /experiment="EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:19556461]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266]" /experiment="EXISTENCE:mutant phenotype:GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering [PMID:19556461]" /experiment="EXISTENCE:physical interaction:GO:0032865 ERMES complex [PMID:21945531]" /note="Mitochondrial component of the ERMES complex; links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase" /db_xref="GeneID:852654" /db_xref="SGD:S000003187" ORIGIN 1 msfrfneavf gdnsfnerir eklstalnsp skkkldilks gikvqkvdfp tipqleildl 61 diitqpksla kgickisckd amlriqtvie snlllineqd tpsftmpqli nngsftipit 121 mtfssielea itnifvknpg igisfndvdl dfkfdcsvki lqstierrlk esmhvvfkdv 181 lpslifntsq nwftnrgest stipgkrehh hqqttmsrnv ildgsdfqel spinmlrlss 241 ivssrstlsl hstvmnslsa ipgclerqnl yrfisrmpsl nnyyssqsfp qpksstvssk 301 qlvkpfycsh nllpktvlds sqydlatitk iqsrlfdrsn snddnakprr rkikckktrt 361 psnlqsqgeq avddstaiet vtstpvqtpi peleeqsppy lkttvsirdk yvipekisln 421 ldskkdtskk kpfyfiglns qepsnnwkwg medspppyh // LOCUS NP_011299 805 aa linear PLN 30-JUN-2025 DEFINITION tubulin-dependent ATPase KIP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011299 VERSION NP_011299.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181081.1 REFERENCE 1 (residues 1 to 805) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 805) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 805) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 805) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07901. Method: conceptual translation. FEATURES Location/Qualifiers source 1..805 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..805 /product="tubulin-dependent ATPase KIP3" /calculated_mol_wt="90960" Region 82..438 /region_name="KISc_KIP3_like" /note="Kinesin motor domain, KIP3-like subgroup; cd01370" /db_xref="CDD:276821" Site order(192,195,197..200,340) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:276821" Site order(391,394,397) /site_type="other" /note="microtubule interaction site [polypeptide binding]" /db_xref="CDD:276821" CDS 1..805 /gene="KIP3" /locus_tag="YGL216W" /coded_by="NM_001181081.1:1..2418" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:16533946]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:16533946]" /experiment="EXISTENCE:direct assay:GO:0005880 nuclear microtubule [PMID:9693366]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:9693366]" /experiment="EXISTENCE:direct assay:GO:0008574 plus-end-directed microtubule motor activity [PMID:16906145|PMID:16906148]" /experiment="EXISTENCE:direct assay:GO:0070462 plus-end specific microtubule depolymerization [PMID:16906148|PMID:16906145]" /experiment="EXISTENCE:direct assay:GO:0070463 tubulin-dependent ATPase activity [PMID:16906148]" /experiment="EXISTENCE:direct assay:GO:1990023 mitotic spindle midzone [PMID:16533946]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:16906148|PMID:9281582]" /experiment="EXISTENCE:mutant phenotype:GO:0007020 microtubule nucleation [PMID:33752231]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:10525539]" /experiment="EXISTENCE:mutant phenotype:GO:0007079 mitotic chromosome movement towards spindle pole [PMID:16533946]" /experiment="EXISTENCE:mutant phenotype:GO:0007080 mitotic metaphase chromosome alignment [PMID:20603597]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:9693366]" /experiment="EXISTENCE:mutant phenotype:GO:0031115 negative regulation of microtubule polymerization [PMID:24616221]" /experiment="EXISTENCE:mutant phenotype:GO:0032888 regulation of mitotic spindle elongation [PMID:24616221]" /experiment="EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:31964755]" /experiment="EXISTENCE:mutant phenotype:GO:0051228 mitotic spindle disassembly [PMID:23851487|PMID:9813090]" /experiment="EXISTENCE:mutant phenotype:GO:0090307 mitotic spindle assembly [PMID:23851487]" /experiment="EXISTENCE:mutant phenotype:GO:0099606 microtubule plus-end directed mitotic chromosome migration [PMID:35791811]" /note="Kinesin-related antiparallel sliding motor protein; involved in mitotic spindle positioning; sliding activity promotes bipolar spindle assembly and maintenance of genome stability; inhibits spindle elongation, destabilizing late anaphase spindle microtubules (MTs) that polymerize beyond the midzone; required for plus-end directed kinetochore movement along metaphase MTs enabling chromosome biorientation and congression; involved in chromosome movement towards the spindle pole during anaphase A" /db_xref="GeneID:852655" /db_xref="SGD:S000003184" ORIGIN 1 mnvpetrqss ivvairvrpf tsmektrlvn easgaeanfp glgdsslilp msnnsdsdid 61 idaeegstrs krnsllrrkv irpegirkiv dcvddrmlif dpadrnplnk vsdqvlnsmr 121 aratkatass innsnatnkf ssqrrrhgge ikfvfdklfd etssqarvyk ettsplldsv 181 ldgfnstvfa ygatgcgkty tvsgtpsqpg iiflameelf nkitdlkdek dfeislsyle 241 iynerirdll kpetpskrlv iredtqnhik vanlsyhhpn tvedvmdlvv qgninrttsp 301 teanevssrs havlqihimq tnklvdltsq htfatlsiid lagseraaat rnrgirlheg 361 aninrsllal gncinalcln dgsrschipy rdskltrllk fslggncktv mivcispsss 421 hydetlntlk yanrakeikt kiirnqqsls rhvgsylkmi teqkrqieel rereekmisl 481 kltkyklnke kiqlainecv nrvqqtyagv etyqvaktlk slilckrrfl qmvklevdnl 541 illfereest aaemqpvisn crmisgqlyn kihelemkfd etdtlssvih qvhsidlnkl 601 remedwdety dlvylescln qiselqrnei lvnssimtek lmsdpglnsr fkflskwlmn 661 rtpniesiiq dlvhideefe sfartfianp dsnftntnin iinttaadla vpaetlqrqn 721 fsqkkvkwts pdlspspmie pqpelepelh qdqdaiasev dvsmqdttfn eqgpstpsap 781 ttavprrkmr ssllthqsll atark // LOCUS NP_011300 452 aa linear PLN 30-JUN-2025 DEFINITION Clg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011300 VERSION NP_011300.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181080.1 REFERENCE 1 (residues 1 to 452) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 452) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 452) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 452) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07902. Method: conceptual translation. FEATURES Location/Qualifiers source 1..452 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..452 /product="Clg1p" /calculated_mol_wt="51440" Region 168..260 /region_name="CYCLIN_ScPCL1-like" /note="cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; cd20557" /db_xref="CDD:410260" Site order(180,224,232..234,248,251..252) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410260" CDS 1..452 /gene="CLG1" /locus_tag="YGL215W" /coded_by="NM_001181080.1:1..1359" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:9032248]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:20417603]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:9032248]" /note="Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2" /db_xref="GeneID:852657" /db_xref="SGD:S000003183" ORIGIN 1 mantfkyype tmgnssgypi slpfpkgsat savnvarqlp kylghvpsqs vhtqlpsmas 61 lgyfnqpsst yyappaplqq hqqppilppp glmytsnnns nvipppvqmi rdgqqqpqqs 121 nqvnggvsen ldydisimsk fimenafvaf nanystddqt tdlffkgiss vlnatrlpsa 181 tiflaidylf kyinklsngi hsiggnsini iyqntmiafi lankfnddkt ftnnswsqat 241 gilinvindf erqwlrifnw elydsaflyf efvknfeifk qnqlkpavav ptllspivnv 301 gdtrnvnfnl kptstnnlls pvsnyetpml mphnmfssps yqsnsrsefs smngyynyyn 361 ynqprlnyyq qfpniysspi setqfdydfy nfssqqqqqq qkqhsllpaa pqlppphvhn 421 qsyghhlgwk smddtinhsr fernyfpysa vy // LOCUS NP_011302 397 aa linear PLN 30-JUN-2025 DEFINITION SKI complex subunit WD repeat protein SKI8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011302 VERSION NP_011302.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181078.1 REFERENCE 1 (residues 1 to 397) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 397) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 397) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 397) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07903. Method: conceptual translation. FEATURES Location/Qualifiers source 1..397 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..397 /product="SKI complex subunit WD repeat protein SKI8" /calculated_mol_wt="44101" Region 13..351 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(15,31,35,41..42,60..61,86,90,96..97,121..122,142,147, 153..154,185,201,206,212..213,225,227,250,254,263..264, 289..290,307,312,318..319,331..332) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 19..60 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 66..119 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 124..180 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <190..336 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 190..224 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 236..275 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 294..330 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 357..391 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..397 /gene="SKI8" /locus_tag="YGL213C" /gene_synonym="REC103" /coded_by="NM_001181078.1:1..1194" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:14992724]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14992724]" /experiment="EXISTENCE:direct assay:GO:0055087 Ski complex [PMID:18042677|PMID:10744028]" /experiment="EXISTENCE:genetic interaction:GO:0007131 reciprocal meiotic recombination [PMID:14992724]" /experiment="EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:9482746]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:14992724]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:14992724]" /experiment="EXISTENCE:mutant phenotype:GO:0065004 protein-DNA complex assembly [PMID:14992724]" /experiment="EXISTENCE:mutant phenotype:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:11910110|PMID:17660569]" /experiment="EXISTENCE:physical interaction:GO:0007131 reciprocal meiotic recombination [PMID:14992724]" /experiment="EXISTENCE:physical interaction:GO:0055087 Ski complex [PMID:18042677]" /note="Ski complex component and WD-repeat protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype" /db_xref="GeneID:852659" /db_xref="SGD:S000003181" ORIGIN 1 mskvfiatan agkahdadif svsacnsftv scsgdgylkv wdnklldnen pkdksyshfv 61 hksglhhvdv lqaierdafe lclvattsfs gdllfyritr edetkkvife kldlldsdmk 121 khsfwalkwg asndrllshr lvatdvkgtt yiwkfhpfad esnsltlnws ptlelqgtve 181 spmtpsqfat svdisergli atgfnngtvq iselstlrpl ynfesqhsmi nnsnsirsvk 241 fspqgsllai ahdsnsfgci tlyetefger igslsvpths sqaslgefah sswvmslsfn 301 dsgetlcsag wdgklrfwdv ktkerittln mhcddieiee dilavdehgd slaepgvfdv 361 kflkkgwrsg mgadlneslc cvcldrsirw freaggk // LOCUS NP_011303 316 aa linear PLN 30-JUN-2025 DEFINITION Vam7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011303 VERSION NP_011303.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181077.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07904. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..316 /product="Vam7p" /calculated_mol_wt="36580" Region 13..120 /region_name="PX_SNARE" /note="The phosphoinositide binding Phox Homology domain of SNARE proteins from fungi; cd06897" /db_xref="CDD:132807" Site order(41..43,66..67,88) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:132807" Region 253..311 /region_name="SNARE_VAM7" /note="SNARE motif of VAM7; cd15858" /db_xref="CDD:277211" Site order(257..260,262..264,266..268,270..271,273..278, 280..281,283..284,287..288,290..292,294..296,298..299, 301..302,305..306,308..309,311) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277211" Site 284 /site_type="other" /note="zero layer" /db_xref="CDD:277211" CDS 1..316 /gene="VAM7" /locus_tag="YGL212W" /gene_synonym="VPL24; VPS43" /coded_by="NM_001181077.1:1..951" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:27881666|PMID:16984909|PMID:11433291]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:19805279]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:17400548]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:27365394]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:16984909]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0031201 SNARE complex [PMID:9628864]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:27365394]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:17400548]" /experiment="EXISTENCE:mutant phenotype:GO:0061909 autophagosome-lysosome fusion [PMID:26774783]" /experiment="EXISTENCE:physical interaction:GO:0031201 SNARE complex [PMID:9628864]" /note="Vacuolar membrane protein and Qc class t-SNARE; functions as a SNAP receptor; involved with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds both PtdIns-3-P and phosphatidic acid, and mediates membrane binding; localizes to both the vacuolar membrane and the phagophore assembly site; SNAP-25 homolog; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852660" /db_xref="SGD:S000003180" ORIGIN 1 maansvgkms eklrikvddv kinpkyvlyg vstpnkrlyk rysefwklkt rlerdvgsti 61 pydfpekpgv ldrrwqrryd dpemiderri glerflnely ndrfdsrwrd tkiaqdflql 121 skpnvsqeks qqhletadev gwdemirdik ldldkesdgt psvrgalrar tklhklrerl 181 eqdvqkkslp stevtrraal lrsllkecdd igtaniaqdr grllgvatsd nssttevqgr 241 tnndlqqgqm qmvrdqeqel valhriiqaq rglalemnee lqtqnellta leddvdntgr 301 rlqiankkar hfnnsa // LOCUS NP_011304 359 aa linear PLN 30-JUN-2025 DEFINITION Ncs6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011304 VERSION NP_011304.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181076.1 REFERENCE 1 (residues 1 to 359) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 359) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 359) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 359) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07905. On Jul 26, 2004 this sequence version replaced NP_011304.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..359 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..359 /product="Ncs6p" /calculated_mol_wt="39856" Region 50..256 /region_name="CTU1-like" /note="cytoplasmic tRNA 2-thiolation protein 1 and similar proteins; cd01713" /db_xref="CDD:467486" Region 220..329 /region_name="TIGR00269" /note="TIGR00269 family protein" /db_xref="CDD:129370" CDS 1..359 /gene="NCS6" /locus_tag="YGL211W" /gene_synonym="TUC1; YGL210W-A" /coded_by="NM_001181076.1:1..1080" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:19145231]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18664566]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837|PMID:17592039]" /experiment="EXISTENCE:mutant phenotype:GO:0002143 tRNA wobble position uridine thiolation [PMID:19151091|PMID:18664566|PMID:19145231]" /experiment="EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14551258]" /note="Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs; required for the thiolation of uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae; localizes to cytosol and peroxisomes" /db_xref="GeneID:852661" /db_xref="SGD:S000003179" ORIGIN 1 msftapsdpv nkptkvkvsq lcelchsrka lirrpknlsk lckqcfclvf eteihntiva 61 nnlfqrgekv avgasggkds tvlahmlkll ndrydygiei vllsidegii gyrddslatv 121 krnqqqyglp leifsfkdly dwtmdeivsv agirnsctyc gvfrrqsldr gaaklgishv 181 vtghnaddma etvlmnilrg dvarleksta iitqssgspi krskpfkysy qkeivlyahy 241 mkldyfstec tyapeafrgt areymknlea vrpsciidii qsgenlalka kksnagkrvv 301 kfvdgnrcar cgylssnnic kacmllegle ksraqvaien dtsadgaalk lraleklsf // LOCUS NP_011305 222 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase YPT32 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011305 VERSION NP_011305.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181075.1 REFERENCE 1 (residues 1 to 222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 222) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07906. Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..222 /product="Rab family GTPase YPT32" /calculated_mol_wt="24389" Region 11..175 /region_name="Rab11_like" /note="Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25; cd01868" /db_xref="CDD:206660" Site 11..15 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206660" Site 20..27 /site_type="other" /note="G1 box" /db_xref="CDD:206660" Site order(22..28,39,42,45,71,126..127,129,156..158) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206660" Site order(28..39,41..44) /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206660" Site order(38,43..51) /site_type="other" /note="Switch I region" /db_xref="CDD:206660" Site order(43,47..54,61,63) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206660" Site 45 /site_type="other" /note="G2 box" /db_xref="CDD:206660" Site order(46,48..50,65,67,74..75,78,82,84..87,174) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206660" Site order(46..47,49,67..68,75,77,79..81) /site_type="other" /note="putative GDI interaction site [polypeptide binding]" /db_xref="CDD:206660" Site 46..50 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206660" Site 63..67 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206660" Site 68..71 /site_type="other" /note="G3 box" /db_xref="CDD:206660" Site order(71,73..83) /site_type="other" /note="Switch II region" /db_xref="CDD:206660" Site 74..79 /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206660" Site 82..86 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206660" Site 91..96 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206660" Site 119..123 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206660" Site 126..129 /site_type="other" /note="G4 box" /db_xref="CDD:206660" Site 156..158 /site_type="other" /note="G5 box" /db_xref="CDD:206660" Site 172..175 /site_type="other" /note="Rab subfamily motif 4 (RabSF4)" /db_xref="CDD:206660" CDS 1..222 /gene="YPT32" /locus_tag="YGL210W" /coded_by="NM_001181075.1:1..669" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:15537705]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15537705]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:15537705]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:9151665]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:9151665]" /note="Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication" /db_xref="GeneID:852662" /db_xref="SGD:S000003178" ORIGIN 1 msnedygydy dylfkivlig dsgvgksnll srfttdefni eskstigvef atrtievenk 61 kikaqiwdta gqeryraits ayyrgavgal ivydisksss yencnhwlte lrenaddnva 121 vglignksdl ahlravptde aknfamenqm lftetsalns dnvdkafrel ivaifqmvsk 181 hqvdlsgsgt nnmgsngapk gptisltpap kedkkkkssn cc // LOCUS NP_011306 382 aa linear PLN 30-JUN-2025 DEFINITION Mig2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011306 VERSION NP_011306.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181074.1 REFERENCE 1 (residues 1 to 382) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 382) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 382) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 382) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07907. Method: conceptual translation. FEATURES Location/Qualifiers source 1..382 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..382 /product="Mig2p" /calculated_mol_wt="41917" Region 1..381 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 19..39 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 47..69 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..382 /gene="MIG2" /locus_tag="YGL209W" /gene_synonym="MLZ1" /coded_by="NM_001181074.1:1..1149" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8756637|PMID:9832517]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9832517|PMID:22842922|PMID:22353369]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22353369]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]" /experiment="EXISTENCE:genetic interaction:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9832517]" /experiment="EXISTENCE:genetic interaction:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:22904036]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9832517]" /note="Zinc finger transcriptional repressor; cooperates with Mig1p in glucose-induced gene repression; under low glucose conditions relocalizes to mitochondrion, where it interacts with Ups1p, antagonizes mitochondrial fission factor Dnm1p, indicative of a role in mitochondrial fusion or regulating morphology; regulates filamentous growth in response to glucose depletion; activated in stochastic pulses of nuclear localization in response to low glucose" /db_xref="GeneID:852663" /db_xref="SGD:S000003177" ORIGIN 1 mpkkqtnfpv dnenrpfrcd tchrgfhrle hkkrhlrtht gekphhcafp gcgksfsrsd 61 elkrhmrtht gqsqrrlkka svqkqefltv sgiptiasgv mihqpipqvl panmainvqa 121 vnggniihap navhpmvipi maqpapihas aasfqpatsp mpistytpvp sqsftsfqss 181 igsiqsnsdv ssifsnmnvr vntprsvpns pndgylhqqh ipqqyqhqta spsvakqqkt 241 fahslasals tlqkrtpvsa psttiespss psdsshtsas ssaislpfsn apsqlavake 301 lesvyldsnr yttktrrera kfeipeeqee dtnnsssgsn eeehesldhe ssksrkklsg 361 vklppvrnll kqidvfngpk rv // LOCUS NP_011307 415 aa linear PLN 30-JUN-2025 DEFINITION Sip2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011307 VERSION NP_011307.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181073.2 REFERENCE 1 (residues 1 to 415) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 415) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 415) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 415) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07908. Method: conceptual translation. FEATURES Location/Qualifiers source 1..415 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..415 /product="Sip2p" /calculated_mol_wt="46274" Region 164..249 /region_name="AMPK1_CBM" /note="Glycogen recognition site of AMP-activated protein kinase; pfam16561" /db_xref="CDD:465176" Region 299..412 /region_name="AMPKBI" /note="5'-AMP-activated protein kinase beta subunit, interation domain; smart01010" /db_xref="CDD:214973" CDS 1..415 /gene="SIP2" /locus_tag="YGL208W" /gene_synonym="SPM2" /coded_by="NM_001181073.2:1..1248" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11331606]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12562756]" /experiment="EXISTENCE:direct assay:GO:0031588 nucleotide-activated protein kinase complex [PMID:12393914]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:12556493]" /experiment="EXISTENCE:genetic interaction:GO:0004679 AMP-activated protein kinase activity [PMID:10990457]" /experiment="EXISTENCE:genetic interaction:GO:0007165 signal transduction [PMID:10990457]" /experiment="EXISTENCE:genetic interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:9121458]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:10921902]" /experiment="EXISTENCE:physical interaction:GO:0031588 nucleotide-activated protein kinase complex [PMID:9121458|PMID:7813428]" /note="One of three alternate beta subunits of the Snf1 kinase complex; involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane; SIP2 has a paralog, GAL83, that arose from the whole genome duplication" /db_xref="GeneID:852664" /db_xref="SGD:S000003176" ORIGIN 1 mgtttshpaq kkqttkkcra pimsdvrekp snaqgcepqe mdavskkvte lslnkcsdsq 61 dagqpsregs itkkkstlll rdedeptmpk lsvmetavdt dsgssstsdd eegdiiaqtt 121 epkqdaspdd drsghsspre egqqqirake asggpseiks slmvpveirw qqggskvyvt 181 gsftkwrkmi glipdsdnng sfhvklrllp gthrfrfivd nelrvsdflp tatdqmgnfv 241 nyievrqpek nptnekirsk eadsmrppts drssialqig kdpddfgdgy trfhedlspr 301 ppleyttdip avftdpsvme ryyytldrqq sntdtswltp pqlppqlenv ilnkyyatqd 361 qfnennsgal pipnhvvlnh lvtssikhnt lcvasivryk qkyvtqilyt piess // LOCUS NP_011308 1035 aa linear PLN 30-JUN-2025 DEFINITION chromatin-remodeling protein SPT16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011308 VERSION NP_011308.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181072.1 REFERENCE 1 (residues 1 to 1035) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1035) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1035) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1035) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1035) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07909. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1035 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1035 /product="chromatin-remodeling protein SPT16" /calculated_mol_wt="118500" Region 1..1035 /region_name="COG5406" /note="Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]" /db_xref="CDD:227693" CDS 1..1035 /gene="SPT16" /locus_tag="YGL207W" /gene_synonym="CDC68; SSF1" /coded_by="NM_001181072.1:1..3108" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10413469]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10413469]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:19683499]" /experiment="EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:12952948|PMID:15082784]" /experiment="EXISTENCE:direct assay:GO:0007063 regulation of sister chromatid cohesion [PMID:31582854]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:11432837]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:18089575]" /experiment="EXISTENCE:direct assay:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:15987999]" /experiment="EXISTENCE:genetic interaction:GO:0035101 FACT complex [PMID:11432837]" /experiment="EXISTENCE:genetic interaction:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:15987999]" /experiment="EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:19574230]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27226635]" /experiment="EXISTENCE:physical interaction:GO:0006261 DNA-templated DNA replication [PMID:9199353]" /experiment="EXISTENCE:physical interaction:GO:0035101 FACT complex [PMID:11432837]" /note="Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; specifically required for diauxic shift-induced H2B deposition onto rDNA genes; mutations cause reduced nucleosome occupancy over highly transcribed regions; coregulates transcription with Mot1p through preinitiation complex assembly and nucleosome organization" /db_xref="GeneID:852665" /db_xref="SGD:S000003175" ORIGIN 1 meelnidfdv fkkriellys kynefegspn sllfvlgssn aenpyqktti lhnwllsyef 61 patlialvpg kviiitssak akhlqkaidl fkdpeskitl elwqrnnkep elnkklfddv 121 ialinsagkt vgipekdsyq gkfmtewnpv weaavkenef nvidislgls kvwevkdvne 181 qaflsvsskg sdkfmdllsn emvravdeel kitnaklsdk ienkiddvkf lkqlspdlsa 241 lcppnykfnf dlldwtyspi iqsgkkfdlr vsarstndql ygngcilasc girynnycsn 301 itrtflidps eemannydfl ltlqkeivtn ilkpgrtpke vyesvieyie ktkpelvpnf 361 tknigsligl efrdsnfiln vkndyrkiqr gdcfnisfgf nnlkdsqsan nyalqladtv 421 qipldetepp rfltnytkak sqisfyfnne eednnkkkss patkvpskpd rnskilrtkl 481 rgearggaed aqkeqirken qkklheklek ngllrfsaad angpdseprq yfkkyesyvr 541 dsqlptnird lrihvdwksq tiilpiygrp vpfhinsykn gskneegeyt ylrlnfnspg 601 ssggiskkve elpyeesadn qfvrsitlrs kdgdrmsetf kqiadlkkea tkreqerkal 661 advvqqdkli enktgrtkrl dqifvrpnpd tkrvpstvfi hengirfqsp lrtdsridil 721 fsniknlifq sckgelivvi hihlknpilm gkkkiqdvqf yreasdmsvd etgggrrgqs 781 rfrrygdede leqeqeerrk raaldkefky fadaiaeasn glltventfr dlgfqgvpnr 841 savfcmpttd clvqlieppf lvinleevei cilervqfgl knfdmvfvyk dfnkpvthin 901 tvpiesldfl kqwltdmdip ytvstinlnw atimkslqdd pyqffldggw nflatgsdde 961 asdeseeevs eyeaseddvs desafsedee gsevdddisg desedytgde seegedwdel 1021 ekkaaradrg anfrd // LOCUS NP_011309 1653 aa linear PLN 30-JUN-2025 DEFINITION clathrin heavy chain [Saccharomyces cerevisiae S288C]. ACCESSION NP_011309 VERSION NP_011309.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181071.1 REFERENCE 1 (residues 1 to 1653) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1653) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1653) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1653) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1653) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1653) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1653) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1653) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07910. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1653 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1653 /product="clathrin heavy chain" /calculated_mol_wt="187104" Region 262..294 /region_name="Clathrin_propel" /note="Clathrin propeller repeat; pfam01394" /db_xref="CDD:460192" Region 338..360 /region_name="Clathrin-link" /note="Clathrin, heavy-chain linker; pfam09268" /db_xref="CDD:462732" Region 362..425 /region_name="Clathrin_H_link" /note="Clathrin-H-link; pfam13838" /db_xref="CDD:463995" Region 544..680 /region_name="CLH" /note="Clathrin heavy chain repeat homology; smart00299" /db_xref="CDD:128594" Region 692..830 /region_name="CLH" /note="Clathrin heavy chain repeat homology; smart00299" /db_xref="CDD:128594" Region 839..974 /region_name="CLH" /note="Clathrin heavy chain repeat homology; smart00299" /db_xref="CDD:128594" Region 985..1126 /region_name="CLH" /note="Clathrin heavy chain repeat homology; smart00299" /db_xref="CDD:128594" Region 1134..1273 /region_name="Clathrin" /note="Region in Clathrin and VPS; pfam00637" /db_xref="CDD:459884" Region 1280..1422 /region_name="CLH" /note="Clathrin heavy chain repeat homology; smart00299" /db_xref="CDD:128594" Region 1429..1570 /region_name="Clathrin" /note="Region in Clathrin and VPS; pfam00637" /db_xref="CDD:459884" CDS 1..1653 /gene="CHC1" /locus_tag="YGL206C" /gene_synonym="SWA5" /coded_by="NM_001181071.1:1..4962" /experiment="EXISTENCE:direct assay:GO:0006897 endocytosis [PMID:16643280]" /experiment="EXISTENCE:genetic interaction:GO:0030866 cortical actin cytoskeleton organization [PMID:12181333]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:27062026]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:27062026|PMID:16643280]" /experiment="EXISTENCE:mutant phenotype:GO:0030866 cortical actin cytoskeleton organization [PMID:12181333]" /note="Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function" /db_xref="GeneID:852666" /db_xref="SGD:S000003174" ORIGIN 1 msdlpiefte lvdlmslgis pqfldfrstt fesdhfvtvr etkdgtnsva ivdlakgnev 61 trknmggdsa imhpsqmvis vrangtivqi fnletksklk sftldepvif wrwlsettlg 121 fvtarsilts nvfdgnvnak pqlltlrhan lnntqiinfv anknldwfav vgilqengri 181 agriqlfskq rnisqaidgh vaiftnille gngstpvqvf vtgnrnattg agelriieid 241 hdaslpsqyq kettdiffpp datndfpiav qvsekygiiy lltkygfihl yeletgtnlf 301 vnritaesvf taapynheng iacinkkgqv laveistsqi vpyilnklsn valalivatr 361 gglpgaddlf qkqfeslllq ndyqnaakva asstslrnqn tinrlkniqa ppgaispill 421 yfstlldkgk lnkeetiela rpvlqqdrkq lfekwlkedk lecseelgdi vkpfdttlal 481 acylragaha kvisclaelq qfekiipycq kvgyqpnflv lisslirssp drasefavsl 541 lqnpetasqi diekiadlff sqnhiqqgts llldalkgdt pdqghlqtrv levnllhapq 601 vadailgnni fshydkptia slsekaglyq ralenytdik dikrcvvhtn alpidwlvgy 661 fgklnveqsl aclkalmdnn iqaniqtvvq vatkfsdlig pstliklfed ynateglyyy 721 laslvnlted kdvvykyiea aakmkqyrei erivkdnnvy dpervknflk danledqlpl 781 vivcdrfdfv hemilylyks qnlkfietyv qqvnpsktaq vvgalldmdc deafiqsllq 841 svlgqvpine lttevekrnr lkillpfleq slsqgiqdqa vynalakiyi dsnnspekfl 901 kendqydtld vghycekrdp ylayiayekg qndddlirit nensmykyqa ryllersdld 961 lwnkvlnqen ihrrqlidsv isvgipeltd pepvsltvqa fmtnglklel iellekiile 1021 pspfnenval qgllllsaik yeptkvssyi ekldnydade iaplciehdl keeafeiydk 1081 hemygkalkv liedimsldr aasyadkint pelwsqigta qldglripda iesyikaedp 1141 snyenvidia eqagkyeeli pfllmarktl kepkidgali layaelnkih eienllagsn 1201 vanldhvgdk lfenkeykaa rlcysavsny sklastlvyl gdyqaavdta rkasnikvwk 1261 lvndaciekk efklaqicgl nlivhaeeld elveryesng yfeelislfe aglglerahm 1321 gmftelaily skyepdktfe hlklfwsrin ipkviraveq ahlwselvfl yahydewdna 1381 altliekstk dldhayfkev vvkvsnleiy ykainfyvkf hpsllvdllt sltprldipr 1441 tvkifsksdn lplikpflin vlpknnsvvn qayhdlmiee edykalqdav dsydkfdqlg 1501 lasrleshkl iffkkigall yrrnkkwaks lsilkeeklw kdaietaais qdpkvveall 1561 tyfvetgnre gfvallyaay nlvriefvle iswmnsledy ikpfeisikk eqndsikkit 1621 eelakksgsn eehkdgqplm lmnsamnvqp tgf // LOCUS NP_011310 748 aa linear PLN 30-JUN-2025 DEFINITION acyl-CoA oxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011310 VERSION NP_011310.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181070.1 REFERENCE 1 (residues 1 to 748) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 748) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 748) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 748) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07911. Method: conceptual translation. FEATURES Location/Qualifiers source 1..748 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..748 /product="acyl-CoA oxidase" /EC_number="1.3.3.6" /calculated_mol_wt="83911" Region 18..702 /region_name="AXO" /note="Peroxisomal acyl-CoA oxidase; cd01150" /db_xref="CDD:173839" Site order(85..86,90,94,191..196,198,225..226,232..233,260, 274..279,281..282,363,365,374,379..381,386,457,460, 465..466,468,470,478..479,482,492,580,584..585,587,589,693, 699..700) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:173839" Site order(153,186..189,226..228,282,341,468,487..488) /site_type="active" /db_xref="CDD:173839" Site 488 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:173839" Site 504 /site_type="active" /note="end of homology with other ACAD's [active]" /db_xref="CDD:173839" CDS 1..748 /gene="POX1" /locus_tag="YGL205W" /gene_synonym="FOX1" /coded_by="NM_001181070.1:1..2247" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:11967269]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:12819196]" /note="Fatty-acyl coenzyme A oxidase; involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix; component of a light sensing pathway, converting light into a hydrogen peroxide signal, modulating nucleo-cytoplasmic shuttling of stress-responsive transcription factor, Msn2p" /db_xref="GeneID:852667" /db_xref="SGD:S000003173" ORIGIN 1 mtrrttinpd svvlnpqkfi qkeradskik vdqvntfles sperrtltha lidqivndpi 61 lktdtdyyda kkmqereita kkiarlasym ehdiktvrkh frdtdlmkel qandpdkasp 121 ltnkdlfifd krlslvanid pqlgtrvgvh lglfgncikg ngtdeqiryw lqergatlmk 181 giygcfamte lghgsnvaql qtravydkqn dtfvidtpdl tatkwwigga ahsathaavy 241 arlivegkdy gvktfvvplr dpstfqllag vsigdigakm grdgidngwi qfrnvvipre 301 fmlsrftkvv rspdgsvtvk tepqldqisg ysallsgrvn mvmdsfrfgs kfatiavrya 361 vgrqqfaprk glsetqlidy plhqyrvlpq lcvpylvspv afklmdnyys tldelynass 421 saykaalvtv skklknlfid saslkatntw liatlidelr qtcgghgysq yngfgkgydd 481 wvvqctwegd nnvlsltsak silkkfidsa tkgrfdntld vdsfsylkpq yigsvvsgei 541 ksglkelgdy teiwsitlik llahigtlve ksrsidsvsk llvlvskfha lrcmlktyyd 601 klnsrdshis deitkesmwn vyklfslyfi dkhsgefqqf kiftpdqisk vvqpqllall 661 pivrkdcigl tdsfelpdam lnspigyfdg diyhnyfnev crnnpveadg agkpsyhall 721 ssmlgrgfef dqklggaana eilskink // LOCUS NP_001257675 101 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL204C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257675 VERSION NP_001257675.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270746.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35109. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..101 /product="uncharacterized protein" /calculated_mol_wt="11220" CDS 1..101 /locus_tag="YGL204C" /coded_by="NM_001270746.1:1..306" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; mRNA identified as translated by ribosome profiling data; protein identified via enrichment-based proteogenomics; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum" /db_xref="GeneID:852669" /db_xref="SGD:S000003172" ORIGIN 1 mngtdilrfl qssptisysk hfilitacpl fvlgllllgl rtamfkqvrg ktttsrnrgv 61 iaakllvawy lativmyiak semwkyafav slllnslalf f // LOCUS NP_011312 729 aa linear PLN 30-JUN-2025 DEFINITION serine-type carboxypeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011312 VERSION NP_011312.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181068.1 REFERENCE 1 (residues 1 to 729) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 729) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 729) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 729) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 729) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 729) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 729) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 729) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07912. Method: conceptual translation. FEATURES Location/Qualifiers source 1..729 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..729 /product="serine-type carboxypeptidase" /EC_number="3.4.16.6" /calculated_mol_wt="82114" Region 37..484 /region_name="Peptidase_S10" /note="Serine carboxypeptidase; pfam00450" /db_xref="CDD:459815" CDS 1..729 /gene="KEX1" /locus_tag="YGL203C" /coded_by="NM_001181068.1:1..2190" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004185 serine-type carboxypeptidase activity [PMID:2668738]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:8308064]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:23656787]" /note="Cell death protease essential for hypochlorite-induced apoptosis; involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins" /db_xref="GeneID:852670" /db_xref="SGD:S000003171" ORIGIN 1 mfynrwlgtw lamsaliris vslpsseeyk vayellpgls evpdpsnipq mhaghiplrs 61 edadeqdssd leyffwkftn ndsngnvdrp liiwlnggpg cssmdgalve sgpfrvnsdg 121 klylnegswi skgdllfidq ptgtgfsveq nkdegkidkn kfdedledvt khfmdfleny 181 fkifpedltr kiilsgesya gqyipffana ilnhnkfski dgdtydlkal ligngwidpn 241 tqslsylpfa mekklidesn pnfkhltnah encqnlinsa stdeaahfsy qecenilnll 301 lsytressqk gtadclnmyn fnlkdsypsc gmnwpkdisf vskffstpgv idslhldsdk 361 idhwkectns vgtklsnpis kpsihllpgl lesgieivlf ngdkdlicnn kgvldtidnl 421 kwggikgfsd davsfdwihk skstddseef sgyvkydrnl tfvsvynash mvpfdkslvs 481 rgivdiysnd vmiidnngkn vmittdddsd qdattesgdk pkenleeeeq eaqneegkek 541 egnkdkdgdd dndndddded dhnsegdddd dddddeddnn ekqsnqgled srhksseyeq 601 eeeeveefae eismykhkav vvtivtfliv vlgvyaydrr vrrkarhtil vdpnnrqhds 661 pnktvswadd lesglgaedd leqdeqlegg apisstsnka gsklktkkkk kytslpntei 721 desfemtdf // LOCUS NP_011313 500 aa linear PLN 30-JUN-2025 DEFINITION bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011313 VERSION NP_011313.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181067.1 REFERENCE 1 (residues 1 to 500) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 500) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 500) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 500) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07913. Method: conceptual translation. FEATURES Location/Qualifiers source 1..500 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..500 /product="bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase" /EC_number="2.6.1.39" /EC_number="2.6.1.57" /calculated_mol_wt="56047" Region <101..494 /region_name="ARO8" /note="DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; COG1167" /db_xref="CDD:440781" CDS 1..500 /gene="ARO8" /locus_tag="YGL202W" /coded_by="NM_001181067.1:1..1503" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0047536 2-aminoadipate transaminase activity [PMID:19342587]" /experiment="EXISTENCE:genetic interaction:GO:0006571 tyrosine biosynthetic process [PMID:9491082]" /experiment="EXISTENCE:genetic interaction:GO:0009094 L-phenylalanine biosynthetic process [PMID:9491082]" /experiment="EXISTENCE:mutant phenotype:GO:0008793 aromatic-amino-acid transaminase activity [PMID:9491082]" /experiment="EXISTENCE:mutant phenotype:GO:0009072 aromatic amino acid metabolic process [PMID:9491083]" /experiment="EXISTENCE:mutant phenotype:GO:0047536 2-aminoadipate transaminase activity [PMID:9491082]" /note="Aromatic aminotransferase I; expression is regulated by general control of amino acid biosynthesis; involved with Aro9p in production of kynurenic acid to detoxify excess tryptophan" /db_xref="GeneID:852672" /db_xref="SGD:S000003170" ORIGIN 1 mtlpeskdfs ylfsdetnar kpsplktcih lfqdpniifl ggglplkdyf pwdnlsvdsp 61 kppfpqgiga pideqnciky tvnkdyadks anpsndipls ralqygfsag qpellnfird 121 htkiihdlky kdwdvlatag ntnawestlr vfcnrgdvil veahsfsssl asaeaqgvit 181 fpvpidadgi ipeklakvme nwtpgapkpk llytiptgqn ptgtsiadhr keaiykiaqk 241 ydflivedep yyflqmnpyi kdlkerekaq sspkqdhdef lkslantfls ldtegrvirm 301 dsfskvlapg trlgwitgss kilkpylslh emtiqapagf tqvlvnatls rwgqkgyldw 361 llglrheytl krdcaidaly kylpqsdafv inppiagmff tvnidasvhp efktkynsdp 421 yqleqslyhk vvergvlvvp gswfkseget eppqpaeske vsnpniiffr gtyaavspek 481 lteglkrlgd tlyeefgisk // LOCUS NP_011314 1017 aa linear PLN 30-JUN-2025 DEFINITION MCM DNA helicase complex subunit MCM6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011314 VERSION NP_011314.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181066.1 REFERENCE 1 (residues 1 to 1017) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1017) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1017) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1017) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07914. On Feb 2, 2004 this sequence version replaced NP_011314.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1017 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1017 /product="MCM DNA helicase complex subunit MCM6" /EC_number="3.6.4.12" /calculated_mol_wt="112848" Region 112..195 /region_name="MCM_N" /note="MCM N-terminal domain; pfam14551" /db_xref="CDD:464206" Region 272..836 /region_name="MCM" /note="minichromosome maintenance proteins; smart00350" /db_xref="CDD:214631" Site order(536..538,577..582,798) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350663" Site order(558..559,565,577..578,586,597..599,601..604,606..607, 621,623..624,626..627,629,632,639..640,643,666..669, 671..673,719,724,728,731..732,734..736,770,774,777..778, 781..782,792..794,796..797,800..801,804) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:350663" Site order(606,611..612,614,645,665..666) /site_type="other" /note="nucleic acid binding site [nucleotide binding]" /db_xref="CDD:350663" Region 900..1007 /region_name="MCM6_C" /note="MCM6 C-terminal winged-helix domain; pfam18263" /db_xref="CDD:465688" CDS 1..1017 /gene="MCM6" /locus_tag="YGL201C" /coded_by="NM_001181066.1:1..3054" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:15723534]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:11756674|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10704410]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10704410]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0006260 DNA replication [PMID:13679365|PMID:15723534]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0009378 four-way junction helicase activity [PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:15723534|PMID:18657510]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0042555 MCM complex [PMID:12480933]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:direct assay:GO:0097373 MCM core complex [PMID:13679365]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:10834843]" /note="Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p" /db_xref="GeneID:852673" /db_xref="SGD:S000003169" ORIGIN 1 msspfpadtp ssnrpsnssp ppssigagfg sssgldsqig srlhfpsssq phvsnsqtgp 61 fvndstqfss qrlqtdgsat ndmegnepar sfksralnhv kkvddvtgek vreafeqfle 121 dfsvqstdtg evekvyraqi efmkiydlnt iyidyqhlsm rengalamai seqyyrflpf 181 lqkglrrvvr kyapellnts dslkrsegde gqadedeqqd ddmngsslpr dsgssaapgn 241 gtsamatrsi ttstspeqte rvfqisffnl ptvhrirdir sekigsllsi sgtvtrtsev 301 rpelykasft cdmcraivdn veqsfkytep tfcpnpscen rafwtlnvtr srfldwqkvr 361 iqenaneipt gsmprtldvi lrgdsverak pgdrckftgv eivvpdvtql glpgvkpsst 421 ldtrgisktt eglnsgvtgl rslgvrdlty kisflachvi sigsnigass pdansnnret 481 elqmaanlqa nnvyqdnerd qevflnslss deinelkemv kdehiydklv rsiapavfgh 541 eavkkgillq mlggvhkstv egiklrgdin icvvgdpsts ksqflkyvvg faprsvytsg 601 kassaaglta avvrdeeggd ytieagalml adngiccide fdkmdisdqv aiheameqqt 661 isiakagiha tlnartsila aanpvggryn rklslrgnln mtapimsrfd lffvilddcn 721 ekidtelash ivdlhmkrde aieppfsaeq lrryikyart fkpiltkear sylvekykel 781 rkddaqgfsr ssyritvrql esmirlseai arancvdeit psfiaeaydl lrqsiirvdv 841 ddvemdeefd niesqshaas gnnddnddgt gsgvitsepp adieegqsea tarpgtsekk 901 kttvtydkyv smmnmivrki aevdregaee ltavdivdwy llqkendlgs laeyweerrl 961 afkvikrlvk drilmeihgt rhnlrdlene enennktvyv ihpncevldq lepqdss // LOCUS NP_011315 203 aa linear PLN 30-JUN-2025 DEFINITION Emp24p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011315 VERSION NP_011315.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181065.3 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07915. On Jul 30, 2012 this sequence version replaced NP_011315.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..203 /product="Emp24p" /calculated_mol_wt="23201" Region 20..198 /region_name="EMP24_GP25L" /note="emp24/gp25L/p24 family/GOLD; pfam01105" /db_xref="CDD:426051" CDS 1..203 /gene="EMP24" /locus_tag="YGL200C" /gene_synonym="BST2" /coded_by="NM_001181065.3:1..612" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8862519]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:mutant phenotype:GO:0006621 protein retention in ER lumen [PMID:8862519]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8862519]" /experiment="EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:8862519]" /note="Component of the p24 complex; role in misfolded protein quality control; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles" /db_xref="GeneID:852675" /db_xref="SGD:S000003168" ORIGIN 1 masfatkfvi acflffsasa hnvllpaygr rcffedlskg delsisfqfg drnpqsssql 61 tgdfiiygpe rhevlktvrd tshgeitlsa pykghfqycf lnentgietk dvtfnihgvv 121 yvdlddpntn tldsavrkls kltrevkdeq syivirerth rntaestndr vkwwsifqlg 181 vvianslfqi yylrrffevt slv // LOCUS NP_011317 235 aa linear PLN 30-JUN-2025 DEFINITION Yip4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011317 VERSION NP_011317.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181063.1 REFERENCE 1 (residues 1 to 235) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 235) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 235) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07916. On Feb 2, 2004 this sequence version replaced NP_011317.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..235 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..235 /product="Yip4p" /calculated_mol_wt="25864" Region 1..231 /region_name="YIP1" /note="Rab GTPase interacting factor, Golgi membrane protein [Intracellular trafficking and secretion]; cl46908" /db_xref="CDD:481248" CDS 1..235 /gene="YIP4" /locus_tag="YGL198W" /coded_by="NM_001181063.1:1..708" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:17178117]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:11943201]" /note="Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport" /db_xref="GeneID:852676" /db_xref="SGD:S000003166" ORIGIN 1 msygredtti epdfiepdap laasggvadn iggtmqnsgs rgtldetvlq tlkrdvvein 61 srlkqvvyph fpsffspsdd gigaadndis ancdlwapla fiilyslfvs harslfsslf 121 vsswfillvm alhlrltkph qrvslisyis isgyclfpqv lnalvsqill playhigkqn 181 rwivrvlslv klvvmalclm wsvaavswvt ksktiieiyp lalclfgmaw lstil // LOCUS NP_011318 1487 aa linear PLN 30-JUN-2025 DEFINITION Mds3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011318 VERSION NP_011318.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181062.2 REFERENCE 1 (residues 1 to 1487) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1487) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1487) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1487) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07917. On Apr 26, 2011 this sequence version replaced NP_011318.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1487 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1487 /product="Mds3p" /calculated_mol_wt="166841" Region <156..>263 /region_name="NanM" /note="N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; COG3055" /db_xref="CDD:442289" Region 160..210 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 216..263 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" CDS 1..1487 /gene="MDS3" /locus_tag="YGL197W" /coded_by="NM_001181062.2:1..4464" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0075297 negative regulation of ascospore formation [PMID:9383076]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:24603354]" /experiment="EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:20457806]" /experiment="EXISTENCE:mutant phenotype:GO:0075297 negative regulation of ascospore formation [PMID:9383076]" /note="Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain; MDS3 has a paralog, PMD1, that arose from the whole genome duplication" /db_xref="GeneID:852678" /db_xref="SGD:S000003165" ORIGIN 1 mpllqpstcf cyplklpplp ltsdsnefde carkrltldy rtgsavtltr snifvhgglt 61 iplnlpvvns mqlqkelilf fakeknngss frnlnewisk etffldlmsr twyrvktsfd 121 qrteellkae sssakadndt neirtdikkg kslesplker lfhslcyldg clyifggltv 181 spqsgyelia tnelwkldln tkkwsllsdd pqiarrfnht mhvknenndn rdtkliivgg 241 lnnmdqpvkk idiynisqnc wqsetipkqp meittnvngi plalskdqnf silvennean 301 vpalafymrs dqideylgkd sskikenspi valpllsesq girmpsnpal pkkllnvpye 361 llaptgdyfg fniiiggfhp nyqssnfhcf iydinsgkws rvatacpdcd inkhrfwrvf 421 vwkshhqtil lgtktddyys psvqrfdhls tfglplvnif nktiqlphhk isasslpipi 481 enfakhkdtp lkkvsftssa tsqfenyiry iapplemssi qsvfppyamv lgkdaleiyg 541 kplsdfefit segdsigipc yllrkrwgry fdmllsqsyt kvcadyettd tqstlikfsp 601 hssrnsskav rqegrlsssg sldnyfeknf pifartsvse aqntqpqvan adakapntps 661 tsdepsssss sdlystphyq rnndeedded pvspkpvsks nsiyrpirkt esssttsssn 721 gmifrvpfke kaavtsntea llesnlslqe lsrrrsslms ipsgellrss iseaehqrra 781 shpltssplf edsgtpcgkq lqqlqqhtiq nphnhlsprr fsrsarssis yvssssdrrg 841 nsissrstsd sfgtppvlgv lnvplppqtr epneppppcp amstgsntrr sntltdymhs 901 nkaspfssrr sshigrrsst petenafsat prasldgqml gkslkegsts qytqprmnsf 961 pkanetiqtp tssnnewsrq svtsntdsfd slqsnfalel eplltprsly mpwptstvra 1021 faeffytgqv nskwllapva ldllvmakiy eipllyklil evlysilakk eeslslicts 1081 lmetfrtktl nsykgdeekt ntyltsndny qellklkvsl enidngyydp dllrkqsraq 1141 ssstqessgs angektatga gsletsstnv ptvfaggprd shnsvgsigf pnsmniqgsr 1201 rstsgfsprv kmksslskei dpktfyeeye pkegksfddn ddqqtnigsf nlhlfdmnyg 1261 sisssstnsi sssdleekee qeqlqdllei eredsaeild arfrnkeddk vtkdisndkk 1321 rnylpheknn lkakegketr dvreeeeefd fglgmlslnk ikreakhvdk vddsvdplfk 1381 ssafpqspir aygsttrtss asgkpfrdnr sfnafsvltl enmasanalp pvdyviksiy 1441 rttvlvndir lmvrcmdcie lsknlralkk ktmedisklk giskpsp // LOCUS NP_011319 428 aa linear PLN 30-JUN-2025 DEFINITION D-serine ammonia-lyase DSD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011319 VERSION NP_011319.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181061.1 REFERENCE 1 (residues 1 to 428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 428) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07918. On Jul 26, 2004 this sequence version replaced NP_011319.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..428 /product="D-serine ammonia-lyase DSD1" /EC_number="4.3.1.18" /calculated_mol_wt="47697" Region 13..428 /region_name="PLPDE_III_DSD" /note="Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Eukaryotic D-Serine Dehydratase; cd06817" /db_xref="CDD:143491" Site order(18,57,59,86..87,89..90,96,120,139,142,146,170..173, 315..318,323,325,327,330..331,410) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:143491" Site order(55,57,84,112,164,171,205,254..255,284..287,330) /site_type="active" /db_xref="CDD:143491" Site order(55,57,84,112,164,205,254..255,284..287) /site_type="other" /note="pyridoxal 5'-phosphate (PLP) binding site [chemical binding]" /db_xref="CDD:143491" Site order(57,171,205,287) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:143491" Site 57 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:143491" CDS 1..428 /gene="DSD1" /locus_tag="YGL196W" /coded_by="NM_001181061.1:1..1287" /experiment="EXISTENCE:direct assay:GO:0008721 D-serine ammonia-lyase activity [PMID:17937657|PMID:17869212]" /experiment="EXISTENCE:mutant phenotype:GO:0070178 D-serine metabolic process [PMID:17937657]" /note="D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate" /db_xref="GeneID:852679" /db_xref="SGD:S000003164" ORIGIN 1 msdvlsqykg csvrdlptpn fvineekfdk ncttmlnnve klsqecgvpi kfrahvkthk 61 takgtlkqlg hglplakrtt railvstlke aeellnyqdr qcsdyiddit yslpccvpef 121 ipllsnlsrr vnnfqvfvdn iehlenlknf grpasgkkws vfikvdmgtk raglafdspe 181 flsllkklts seikeviepy gfyahaghsy sstsindtqn llmeevkavn saakvlcsvd 241 pqfdpskltl svgatptsns lkldnkstlv kfittqlvst leihcgnycm ydlqqvatgc 301 vqdhelsgfv lgtvlssyps rgellsntgv mcltreassi kgfgicadle hvlksesfsr 361 ewyvarvsqe hgilrpirnw nettplklgs kiavlpqhac itmgqfpyyf vvnsegivnd 421 vwlpfqkw // LOCUS NP_011320 2672 aa linear PLN 30-JUN-2025 DEFINITION Gcn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011320 VERSION NP_011320.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181060.3 REFERENCE 1 (residues 1 to 2672) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2672) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 2672) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2672) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 2672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07919. On Jul 30, 2012 this sequence version replaced NP_011320.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2672 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..2672 /product="Gcn1p" /calculated_mol_wt="296568" Region 392..670 /region_name="Gcn1_N" /note="Generalcontrol nonderepressible 1 (Gcn1) N-terminal; pfam12074" /db_xref="CDD:463457" Region 1327..1353 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1368..1397 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1397..1551 /region_name="HEAT" /note="HEAT repeat [General function prediction only]; COG1413" /db_xref="CDD:441023" Region 1411..1435 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(1427..1428,1431,1434..1435,1465..1466,1469, 1472..1473,1476,1506..1507,1510,1513..1514,1517,1543..1544, 1547,1550..1551,1583..1584,1587,1590..1591) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 1448..1476 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1461..1508 /region_name="HEAT_EZ" /note="HEAT-like repeat; pfam13513" /db_xref="CDD:463906" Region 1488..1518 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1526..1551 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1563..1592 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1575..1671 /region_name="HEAT_2" /note="HEAT repeats; pfam13646" /db_xref="CDD:433376" Region 1601..1636 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1615..1748 /region_name="HEAT" /note="HEAT repeat [General function prediction only]; COG1413" /db_xref="CDD:441023" Region 1645..1676 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1684..1710 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1723..1748 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1763..1789 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1830..1856 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1868..1896 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(1888..1889,1892,1895..1896,1927..1928,1931, 1934..1935,1938,1969..1970,1973,1976..1977,1980,2005..2006, 2009,2012..2013,2040..2041,2044,2047..2048) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 1909..1938 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1951..1981 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1989..2013 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 2019..2049 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 2060..2088 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 2099..2128 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..2672 /gene="GCN1" /locus_tag="YGL195W" /gene_synonym="AAS103; NDR1" /coded_by="NM_001181060.3:1..8019" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9234705]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:8947054]" /experiment="EXISTENCE:direct assay:GO:0019887 protein kinase regulator activity [PMID:33338396]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:9234705]" /experiment="EXISTENCE:direct assay:GO:0072344 rescue of stalled ribosome [PMID:33338396]" /experiment="EXISTENCE:direct assay:GO:0140469 GCN2-mediated signaling [PMID:33338396|PMID:8798780]" /experiment="EXISTENCE:direct assay:GO:0170011 stalled ribosome sensor activity [PMID:33338396]" /experiment="EXISTENCE:mutant phenotype:GO:0006448 regulation of translational elongation [PMID:9234705]" /experiment="EXISTENCE:mutant phenotype:GO:0019887 protein kinase regulator activity [PMID:11101534]" /note="Positive regulator of the Gcn2p kinase activity; forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA; suppresses frameshifting at stalled ribosomes" /db_xref="GeneID:852680" /db_xref="SGD:S000003163" ORIGIN 1 mtailnwedi spvlekgtre shvskrvpfl qdisqlvrqe tlekpqlsei afvllntfti 61 yednrskslv tsilldilnl epcllenfir fisdvvisnp atkavadyln lldwinsfli 121 fvshnsnlfe eyipkllvah syatfgveti ldnqeegkks qdkqnqhrkr irycifqttv 181 kaflkclkdn ddsisfmkis iktvlesysk lkitsvgvvm imgaltqaal qllsrqpalh 241 svlkensaek yceylgkevf lgknppssfc leiglkpflk efvsqelfik ffipniekav 301 lrspevgfsi lselyagvsp ekvnllnafa ssklinqyfs sfksskevvr svslqsmiil 361 lrkisntdtt ledltklide ifkniksnln adyksliski lieiplthye vsekickgls 421 pyigkegnea altlmlnaff vhyfslgkpi edldkiisag fadkkpalkk cwfaaflnns 481 naaseeviln fidgclefvk dsiihyqthg hacilasief tnkilaldnt elndrvmqli 541 etlpenssig dailtaalst elsienriha vnllqelfyk kpefigfsvi daierrmrvq 601 elipqqntsf kyvtsvllai tselpdkeas ikvlinalvi aqwnifnikn gwaglvlrar 661 ldpaevvkeh asvimekile itgscewidt iygacglqaa ayaafiqpne ftpilcktie 721 adltaddfsr lseedfeifa geegvlvvdv leesmnkkls nknskeyetl mweqkirkeq 781 akknvkklsk eeqelvneql akesavrshv seistrlkrg irlvselska aclvqngiat 841 wfplavtkll ylcsepnisk ltedvnnvfl qlsqnvserl gnirlflgla tlrvhnangi 901 sqdylqeplv elltrvlfri kfvsnqaaid sisltyilpl linvlekgka ialknadkpv 961 vkaefveede eeehlllame iisvhaeafe dpsiprisiv evllsllslp skakiakdcf 1021 nalcqsisva pnqedldmil snllspnqfv rstiletldn efelepfmky spevficrfd 1081 sdpsnreiad fiwefnkfvv ndellkslfp lfnqddsglr lfaanayafg avslftseen 1141 sskdylndll nfykekakpl epildqfglv lvsaseqkdp wqgrstvait lkimakafsa 1201 eddtvvniik flvddgglvd repivrqemk eagvelitlh gsqnskdlip ifeealssst 1261 dsalkenvii lygtlarhlq qsdarihtii erllstldtp sadiqqavsa ciaplvfqfk 1321 qkvgdylgil mekllnptva ssmrkgaawg iaglvkgygi salsefdiir nlieaaedkk 1381 epkrresvgf cfqylseslg kffepyviei lpnilknlgd avpevrdata ratkaimaht 1441 tgygvkklip vavsnldeia wrtkrgsvql lgnmayldpt qlsaslstiv peivgvlnds 1501 hkevrkaade slkrfgevir npeiqklvpv llqaigdptk yteealdsli qtqfvhyidg 1561 pslaliihii hrgmhdrsan ikrkackivg nmailvdtkd lipylqqlid eveiamvdpv 1621 pntrataara lgalverlge eqfpdliprl ldtlsdesks gdrlgsaqal aevisglglt 1681 kldemlptil agvtnfrayi regfmplllf lpvcfgsqfa pyinqiiqpi lsgladnden 1741 irdtalkagk livknyatka vdlllpeler gmfdendrir lssvqltgel lfqvtgissr 1801 nefseedgdh ngefsgklvd vlgqdrrdri laalfvcrnd tsgivrattv diwkalvpnt 1861 pravkeilpt ltgmivthla sssnvlrnia aqtlgdlvrr vggnalsqll psleesliet 1921 snsdsrqgvc ialyeliesa stetisqfqs tivniirtal idesatvrea aalsfdvfqd 1981 vvgktavdev lpyllhmles sdnsdfallg lqeimskksd vifpiliptl lappidafra 2041 salgslaeva gsalykrlsi iinalvdaii gtsedestkg alelaldrvf lsvnddeglh 2101 pllqqimsll ksdniekria vlerlpnffd ktvldfdvyi pnfvshails lddedqrvvn 2161 gnfnalstll kkvdkptlek lvkpakqsla ltgrqgqdva afklprgpnc vlpiflhglm 2221 ygsnderees alaiadvvsk tpaanlkpfv svitgplirv vgerfssdik aailfalnvl 2281 fikipmflrp fipqlqrtfv kslsdatnet lrlraakalg aliehqprvd plvielvtga 2341 kqatdegvkt amlkallevi mkagsklnen sktnivnlve eemlgsndkl avayakligs 2401 lseilsndea hkilqdkvln adldgetgkf ailtlnsflk dapthifntg lidefvsyil 2461 nairspdvyf gengtiaagk llllegekrs pfvkkdaaep fkigdeninl linelskavl 2521 qpasnstdvr rlalvvirtl arfkfdecik qyfdvvgpsv fsclrdpvip iklaaekayl 2581 alfklveedd mhtfnewfak isdrgnsiet vtgttiqlrs vgdytkrvgk rlanvereri 2641 aaggdaetmf sdrfederei wavggveltt di // LOCUS NP_001032578 80 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL194C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032578 VERSION NP_001032578.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184677.1 REFERENCE 1 (residues 1 to 80) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 80) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 80) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 80) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07920. Method: conceptual translation. FEATURES Location/Qualifiers source 1..80 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..80 /product="uncharacterized protein" /calculated_mol_wt="9493" CDS 1..80 /locus_tag="YGL194C-A" /coded_by="NM_001184677.1:1..243" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; identified based on comparisons of the genome sequences of six Saccharomyces species; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum" /db_xref="GeneID:3799973" /db_xref="SGD:S000087160" ORIGIN 1 msnkeitcik pfkiialill ivliinlsyk lflrrylkst viwclgiant drndmmwwqv 61 spllerwvwq lvdnyesgye // LOCUS NP_011321 452 aa linear PLN 30-JUN-2025 DEFINITION histone deacetylase HOS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011321 VERSION NP_011321.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181059.1 REFERENCE 1 (residues 1 to 452) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 452) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 452) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 452) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07921. Method: conceptual translation. FEATURES Location/Qualifiers source 1..452 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..452 /product="histone deacetylase HOS2" /EC_number="3.5.1.98" /calculated_mol_wt="51324" Region 28..338 /region_name="HDAC_Hos2" /note="Class I histone deacetylases including ScHos2 and SpPhd1; cd11598" /db_xref="CDD:212540" Site order(158..159,167..168,194,196,283,290,320,322) /site_type="active" /db_xref="CDD:212540" CDS 1..452 /gene="HOS2" /locus_tag="YGL194C" /gene_synonym="RTL1" /coded_by="NM_001181059.1:1..1359" /experiment="EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:11711434]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0034967 Set3 complex [PMID:11711434]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:19379692]" /experiment="EXISTENCE:mutant phenotype:GO:0032874 positive regulation of stress-activated MAPK cascade [PMID:18487345]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:38783136]" /experiment="EXISTENCE:mutant phenotype:GO:0045835 negative regulation of meiotic nuclear division [PMID:11711434]" /note="Histone deacetylase and subunit of Set3 and Rpd3L complexes; required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; co-localizes with Cmr1p in nuclear foci in response to DNA damage by MMS" /db_xref="GeneID:852681" /db_xref="SGD:S000003162" ORIGIN 1 msgtfsydvk tkeneplfef nsaysprvsy hfnskvshyh ygvkhpmkpf rlmltdhlvs 61 syglhkimdl yetrsatrde llqfhsedyv nflskvspen anklprgtle nfnigddcpi 121 fqnlydyttl ytgasldatr klinnqsdia inwsgglhha kknspsgfcy vndivlsiln 181 llryhprily ididlhhgdg vqeafyttdr vftlsfhkyn geffpgtgdl teigcdkgkh 241 falnvpledg idddsyinlf ksivdplimt fkptlivqqc gadslghdrl gcfnlnikah 301 gecvkfvksf glpmlvvggg gytprnvsrl wtyetgilnd vllpediped ipfrdsfgpd 361 yslypmlddl yenknskkll edirirclen irylqgapsv rmdaeciptq disalteeed 421 kiiqemneet eadssnrlee mekensglia fs // LOCUS NP_011322 103 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL193C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011322 VERSION NP_011322.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181058.1 REFERENCE 1 (residues 1 to 103) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 103) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 103) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 103) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07922. Method: conceptual translation. FEATURES Location/Qualifiers source 1..103 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..103 /product="uncharacterized protein" /calculated_mol_wt="11869" CDS 1..103 /locus_tag="YGL193C" /coded_by="NM_001181058.1:1..312" /note="Haploid-specific gene repressed by a1-alpha2; turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold" /db_xref="GeneID:852682" /db_xref="SGD:S000003161" ORIGIN 1 mnsslnansy ffrkppmlty mvrflycyps pfpiapavtd lpecrgdlsl slfitsftst 61 kertilyaks rlkthipvnl cdryhyipka plyqcrmpcl ysi // LOCUS NP_011323 600 aa linear PLN 30-JUN-2025 DEFINITION mRNA (N6-adenosine)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011323 VERSION NP_011323.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181057.3 REFERENCE 1 (residues 1 to 600) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 600) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 600) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 600) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07923. On Jul 30, 2012 this sequence version replaced NP_011323.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..600 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..600 /product="mRNA (N6-adenosine)-methyltransferase" /EC_number="2.1.1.348" /calculated_mol_wt="69265" Region <21..>98 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Region 342..504 /region_name="MT-A70" /note="pfam05063" /db_xref="CDD:368270" CDS 1..600 /gene="IME4" /locus_tag="YGL192W" /gene_synonym="SPO8" /coded_by="NM_001181057.3:1..1803" /experiment="EXISTENCE:direct assay:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:22685417]" /experiment="EXISTENCE:mutant phenotype:GO:0001734 mRNA m(6)A methyltransferase activity [PMID:12384598]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:12384598|PMID:1545790|PMID:22685417]" /experiment="EXISTENCE:mutant phenotype:GO:1902974 meiotic DNA replication initiation [PMID:31363087]" /experiment="EXISTENCE:mutant phenotype:GO:2000221 negative regulation of pseudohyphal growth [PMID:22685417]" /note="mRNA N6-adenosine methyltransferase; essential for meiosis in S288C but dispensable for meiosis in SK1, mediates N6-adenosine methylation of bulk mRNA during the induction of sporulation which includes the meiotic regulators IME1, IME2 and IME4 itself; repressed in haploids via production of antisense IME4 transcripts; transcribed in diploid cells where antisense transcription is repressed; orthologous to human METTL3 (MT-A70)" /db_xref="GeneID:852683" /db_xref="SGD:S000003160" ORIGIN 1 mindklvhfl iqnyddilra plsgqlkdvy slyisggydd emqklrndkd evlqfeqfwn 61 dlqdiifatp qsiqfdqnll vadrpekivy ldvfslkily nkfhafyytl ksssssceek 121 vsslttkpea dsekdqllgr llgvlnwdvn vsnqglpreq lsnrlqnllr ekpssfqlak 181 erakyttevi eyipicsdys hasllstsvy ivnnkivslq wskisacqen hpglieciqs 241 kihfipnikp qtdislgdcs yldtchklnt cryihylqyi psclqeradr etasenkrir 301 snvsipfytl gncsahcikk alpaqwircd vrkfdfrvlg kfsvviadpa wnihmnlpyg 361 tcndiellgl plhelqdegi iflwvtgrai elgkeslnnw gynvinevsw iktnqlgrti 421 vtgrtghwln hskehllvgl kgnpkwinkh idvdlivsmt retsrkpdel ygiaerlagt 481 harkleifgr dhntrpgwft ignqltgnci yemdverkyq efmksktgts htgtkkidkk 541 qpsklqqqhq qqywnnmdmg sgkyyaeakq npmnqkhtpf eskqqqkqqf qtlnnlyfaq // LOCUS NP_011324 129 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c oxidase subunit VIa [Saccharomyces cerevisiae S288C]. ACCESSION NP_011324 VERSION NP_011324.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181056.1 REFERENCE 1 (residues 1 to 129) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 129) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 129) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 129) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07924. Method: conceptual translation. FEATURES Location/Qualifiers source 1..129 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..129 /product="cytochrome c oxidase subunit VIa" /calculated_mol_wt="14890" Region 3..125 /region_name="COX6A" /note="Cytochrome c oxidase subunit VIa; pfam02046" /db_xref="CDD:426579" Site order(38..40,42,49..50,53,57) /site_type="other" /note="Subunit VIa/I (of dimer complex) interface [polypeptide binding]" /db_xref="CDD:238465" Site order(48,52,55,67,69..70,76..77,98,100..102,104,107, 117..118,122) /site_type="other" /note="Subunit VIa/III interface [polypeptide binding]" /db_xref="CDD:238465" Site 52 /site_type="other" /note="Subunit VIa/Vb interface [polypeptide binding]" /db_xref="CDD:238465" Site 94..97 /site_type="other" /note="Subunit VIa/VIb interface [polypeptide binding]" /db_xref="CDD:238465" Site order(98,102..104,106) /site_type="other" /note="Subunit VIa/I interface [polypeptide binding]" /db_xref="CDD:238465" CDS 1..129 /gene="COX13" /locus_tag="YGL191W" /coded_by="NM_001181056.1:1..390" /experiment="EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:7851399|PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24478450|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:10429195]" /experiment="EXISTENCE:direct assay:GO:0045277 respiratory chain complex IV [PMID:1331058]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8395517]" /experiment="EXISTENCE:mutant phenotype:GO:0097250 mitochondrial respirasome assembly [PMID:22342701]" /note="Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes" /db_xref="GeneID:852684" /db_xref="SGD:S000003159" ORIGIN 1 mfrqcakrya sslppnalkp afgppdkvaa qkfkeslmat ekhakdtsnm wvkisvwval 61 paialtavnt yfvekehaeh rehlkhvpds ewprdyefmn irskpffwgd gdktlfwnpv 121 vnrhiehdd // LOCUS NP_011325 526 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase 2A regulatory subunit CDC55 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011325 VERSION NP_011325.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181055.1 REFERENCE 1 (residues 1 to 526) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 526) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 526) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 526) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07925. Method: conceptual translation. FEATURES Location/Qualifiers source 1..526 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..526 /product="protein phosphatase 2A regulatory subunit CDC55" /calculated_mol_wt="59531" Region 1..526 /region_name="CDC55" /note="Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]; COG5170" /db_xref="CDD:227498" Region 28..69 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 136..181 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 187..223 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 237..288 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 295..331 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..526 /gene="CDC55" /locus_tag="YGL190C" /gene_synonym="TMR4" /coded_by="NM_001181055.1:1..1581" /experiment="EXISTENCE:direct assay:GO:0000159 protein phosphatase type 2A complex [PMID:8600023]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12388751]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12388751]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21536748]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12388751]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12388751]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12388751]" /experiment="EXISTENCE:genetic interaction:GO:0000705 achiasmate meiosis I [PMID:27455870]" /experiment="EXISTENCE:genetic interaction:GO:0019888 protein phosphatase regulator activity [PMID:17550305]" /experiment="EXISTENCE:genetic interaction:GO:0044818 mitotic G2/M transition checkpoint [PMID:20980617]" /experiment="EXISTENCE:genetic interaction:GO:0045143 homologous chromosome segregation [PMID:27455870]" /experiment="EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:27973551]" /experiment="EXISTENCE:mutant phenotype:GO:0000159 protein phosphatase type 2A complex [PMID:8600023]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:16314395]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:23886942]" /experiment="EXISTENCE:mutant phenotype:GO:0010971 positive regulation of G2/M transition of mitotic cell cycle [PMID:21536748]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:32029270]" /experiment="EXISTENCE:mutant phenotype:GO:0061586 positive regulation of transcription by transcription factor localization [PMID:23275436]" /experiment="EXISTENCE:mutant phenotype:GO:0071475 cellular hyperosmotic salinity response [PMID:23275436]" /experiment="EXISTENCE:mutant phenotype:GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint [PMID:23886942|PMID:27191586]" /experiment="EXISTENCE:mutant phenotype:GO:1900182 positive regulation of protein localization to nucleus [PMID:23275436]" /experiment="EXISTENCE:mutant phenotype:GO:1905477 positive regulation of protein localization to membrane [PMID:32029270]" /note="Regulatory subunit B of protein phosphatase 2A (PP2A); Zds1p/2p-dependent localization to cytoplasm promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division, chromosome segregation during achiasmate meiosis; maintains nucleolar sequestration of Cdc14p in early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; controls phosphorylation and stability of Cln2p; homolog of mammalian B55" /db_xref="GeneID:852685" /db_xref="SGD:S000003158" ORIGIN 1 maqnnfdfkf sqcfgdkadi vvteadlita vefdytgnyl atgdkggrvv lfersnsrhc 61 eykfltefqs hdaefdylks leieekinei kwlrptqrsh fllstndkti klwkvyekni 121 klvsqnnlte gvtfakkgkp dnhnsrggsv ravlslqslk lpqlsqhdki iaatpkriys 181 nahtyhinsi slnsdqetfl saddlrinlw nldipdqsfn ivdikptnme eltevitsae 241 fhpqecnlfm yssskgtikl cdmrqnslcd nktktfeeyl dpinhnffte itssisdikf 301 spngryiasr dyltvkiwdv nmdnkplkti niheqlkerl sdtyendaif dkfevnfsgd 361 sssvmtgsyn nnfmiypnvv tsgdndngiv ktfdehnapn snsnknihns iqnkdssssg 421 nshkrrsngr ntgmvgssns srssiaggeg ansedsgtem neivlqadkt afrnkrygsl 481 aqrsarnkdw gddidfkkni lhfswhpren siavaatnnl fifsal // LOCUS NP_011326 119 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS26 RPS26A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011326 VERSION NP_011326.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181054.1 REFERENCE 1 (residues 1 to 119) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 119) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 119) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 119) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07926. Method: conceptual translation. FEATURES Location/Qualifiers source 1..119 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..119 /product="40S ribosomal protein eS26 RPS26A" /calculated_mol_wt="13374" Region 1..104 /region_name="Ribosomal_S26e" /note="Ribosomal protein S26e; pfam01283" /db_xref="CDD:426179" CDS 1..119 /gene="RPS26A" /locus_tag="YGL189C" /gene_synonym="RPS26" /coded_by="NM_001181054.1:1..360" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:25144938]" /experiment="EXISTENCE:mutant phenotype:GO:0042255 ribosome assembly [PMID:27303706]" /experiment="EXISTENCE:physical interaction:GO:0030686 90S preribosome [PMID:25144938]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S26, no bacterial homolog; RPS26A has a paralog, RPS26B, that arose from the whole genome duplication; human homolog can partially complement an RPS26A, RPS26B double null mutant; mutations in the human gene are associated with Diamond-Blackfan anemia" /db_xref="GeneID:852686" /db_xref="SGD:S000003157" ORIGIN 1 mpkkrasngr nkkgrghvkp vrcvncsksi pkdkaikrma irniveaaav rdlseasvyp 61 eyalpktynk lhycvscaih arivrvrsre drknrappqr prfnrenkvs padaakkal // LOCUS NP_878073 46 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL188C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878073 VERSION NP_878073.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184593.3 REFERENCE 1 (residues 1 to 46) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 46) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 46) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 46) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07927. On Jul 30, 2012 this sequence version replaced NP_878073.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..46 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..46 /product="uncharacterized protein" /calculated_mol_wt="5174" CDS 1..46 /locus_tag="YGL188C-A" /coded_by="NM_001184593.3:1..141" /note="hypothetical protein" /db_xref="GeneID:1466453" /db_xref="SGD:S000028635" ORIGIN 1 mlttqkcesr egkndeifel gesnsdkill khgkcnlfse rkpvnh // LOCUS NP_011328 155 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c oxidase subunit IV [Saccharomyces cerevisiae S288C]. ACCESSION NP_011328 VERSION NP_011328.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181052.1 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07928. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..155 /product="cytochrome c oxidase subunit IV" /calculated_mol_wt="17011" Region 31..155 /region_name="COX5B" /note="Cytochrome c oxidase subunit Vb; pfam01215" /db_xref="CDD:426131" Site order(51,54..57,59,62,64,67,81..82,146) /site_type="other" /note="Subunit Vb/III interface [polypeptide binding]" /db_xref="CDD:238464" Site 51 /site_type="other" /note="Subunit Vb/Va (of dimer complex) interface [polypeptide binding]" /db_xref="CDD:238464" Site 51 /site_type="other" /note="Subunit Vb/VIa interface [polypeptide binding]" /db_xref="CDD:238464" Site order(62,64) /site_type="other" /note="Subunit Vb/VIIa interface [polypeptide binding]" /db_xref="CDD:238464" Site order(83,86,98,102..103,107..110,112,119..120,123,125,141) /site_type="other" /note="Subunit Vb/I interface [polypeptide binding]" /db_xref="CDD:238464" Site order(111,113,134,137) /site_type="other" /note="Zinc binding site [ion binding]" /db_xref="CDD:238464" Site 119 /site_type="other" /note="Subunit Vb/VIa (of dimer complex) interface [polypeptide binding]" /db_xref="CDD:238464" Site 127 /site_type="other" /note="Subunit Vb/IV interface [polypeptide binding]" /db_xref="CDD:238464" Site 133..134 /site_type="other" /note="Subunit Vb/Va interface [polypeptide binding]" /db_xref="CDD:238464" CDS 1..155 /gene="COX4" /locus_tag="YGL187C" /coded_by="NM_001181052.1:1..468" /experiment="EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:1331058|PMID:7851399]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:24478450]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:17215247]" /experiment="EXISTENCE:direct assay:GO:0045277 respiratory chain complex IV [PMID:1331058]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:28100667]" /note="Subunit IV of cytochrome c oxidase; the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation" /db_xref="GeneID:852688" /db_xref="SGD:S000003155" ORIGIN 1 mlslrqsirf fkpatrtlcs sryllqqkpv vktaqnlaev ngpetligpg akegtvptdl 61 dqetglarle llgklegidv fdtkpldssr kgtmkdpiii esyddyryvg ctgspagsht 121 imwlkptvne varcwecgsv yklnpvgvpn ddhhh // LOCUS NP_011329 579 aa linear PLN 30-JUN-2025 DEFINITION Tpn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011329 VERSION NP_011329.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181051.1 REFERENCE 1 (residues 1 to 579) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 579) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 579) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 579) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07929. Method: conceptual translation. FEATURES Location/Qualifiers source 1..579 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..579 /product="Tpn1p" /calculated_mol_wt="64416" Region 70..510 /region_name="ncs1" /note="NCS1 nucleoside transporter family; TIGR00800" /db_xref="CDD:273275" Site order(97,100,369,372..373) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271377" Site order(101,178,182,279..280,282,374,378) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:271377" CDS 1..579 /gene="TPN1" /locus_tag="YGL186C" /coded_by="NM_001181051.1:1..1740" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12649274]" /experiment="EXISTENCE:direct assay:GO:0051180 vitamin transport [PMID:12649274]" /experiment="EXISTENCE:direct assay:GO:0090482 vitamin transmembrane transporter activity [PMID:12649274]" /note="Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p" /db_xref="GeneID:852689" /db_xref="SGD:S000003154" ORIGIN 1 mnrdnmdttk rkedhtkhtt dviefyeegt aasslniate kansspsilr riinraawls 61 kkvdamgves tgiqrispye rgtskkqflh vaglwlsatg glssmssfll gpllfglsfr 121 esvasslisv tigcliaayc simgpqsgcr qmvtarylfg wwfvklvala siigvmgwsv 181 vnsvvggeml aaisndkvpl wvgivivtvc sflvaifgik qvikvetyls vpvltaflll 241 yisssdkysf vnayvskgnl dsstrkgnwm sffslcysit atwgsitady yilfpedtpy 301 iqifcltffg tflptcfvgi lglllasvam sykpwsveyd shgmggllwa gfqrwngfgk 361 fcvvvlvfsl vsnniintys aafsiqlssv fcakiprwfw sivctiiclv caligrnhfs 421 tilgnflpmi gywismyfil lfeenlvfrr fflhlytkef ptvtgeingp elvgsskeve 481 kdavtnihll krkhkvtkhr ynwdkwedye vlthgyaatf afivgvagvv vgmaqaywig 541 piaakfgeyg gdvamwlsma fsgvvyppcr ylelrkfgr // LOCUS NP_011330 379 aa linear PLN 30-JUN-2025 DEFINITION putative hydroxyacid dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011330 VERSION NP_011330.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181050.1 REFERENCE 1 (residues 1 to 379) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 379) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 379) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 379) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07930. Method: conceptual translation. FEATURES Location/Qualifiers source 1..379 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..379 /product="putative hydroxyacid dehydrogenase" /calculated_mol_wt="42853" Region 10..367 /region_name="Mand_dh_like" /note="D-Mandelate Dehydrogenase-like dehydrogenases; cd12168" /db_xref="CDD:240645" Site order(67,98..100,136,293,341) /site_type="other" /note="putative ligand binding site [chemical binding]" /db_xref="CDD:240645" Site order(138..139,142,146,149..150,153,155..156,176,178, 181..182,185,193..196,198,214..215,219..220,319,322..324, 330,332,335..336,338..343,346..348,350) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:240645" Site order(140,205..208,228..229,263..267,270,291..293,317,341, 343..344) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:240645" CDS 1..379 /locus_tag="YGL185C" /coded_by="NM_001181050.1:1..1140" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [PMID:17173333]" /note="Putative protein with sequence similar to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:852690" /db_xref="SGD:S000003153" ORIGIN 1 mcdspattgk ptilfiadpc etsatlnska fkekfrilry qldtkeafln flerheqdki 61 caiyagfpaf kkiggmtrsi iehksfprkn lkcivlcsrg ydgwdldtlr kheirlynyq 121 ddeneklidd lklhqvgndv adcalwhile gfrkfsyyqk lsretgntlt arakaaeksg 181 fafghelgnm faesprgkkc lilglgsigk qvayklqygl gmeihyckrs edctmsqnes 241 wkfhlldeti yaklyqfhai vvtlpgtpqt ehlinrkfle hcnpglilvn lgrgkildlr 301 avsdalvtgr inhlgldvfn kepeidekir ssdrltsitp hlgsatkdvf eqscelaltr 361 ilrvvsgeaa sdehfsrvv // LOCUS NP_011331 465 aa linear PLN 30-JUN-2025 DEFINITION cystathionine beta-lyase STR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011331 VERSION NP_011331.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181049.3 REFERENCE 1 (residues 1 to 465) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 465) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 465) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 465) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07931. On Jul 30, 2012 this sequence version replaced NP_011331.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..465 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..465 /product="cystathionine beta-lyase STR3" /EC_number="4.4.1.13" /calculated_mol_wt="51698" Region 6..409 /region_name="cysta_beta_ly_E" /note="cystathionine beta-lyase, eukaryotic; TIGR01329" /db_xref="CDD:273557" Site order(79..80,83,155,186,189,210,213) /site_type="other" /note="pyridoxal 5'-phosphate binding pocket [chemical binding]" /db_xref="CDD:99738" Site 213 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99738" CDS 1..465 /gene="STR3" /locus_tag="YGL184C" /coded_by="NM_001181049.3:1..1398" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:11565790]" /experiment="EXISTENCE:direct assay:GO:0047804 cysteine-S-conjugate beta-lyase activity [PMID:29436228|PMID:21478306]" /experiment="EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:10821189]" /experiment="EXISTENCE:mutant phenotype:GO:0019346 transsulfuration [PMID:10821189]" /experiment="EXISTENCE:mutant phenotype:GO:0047804 cysteine-S-conjugate beta-lyase activity [PMID:10821189]" /note="Peroxisomal cystathionine beta-lyase; converts cystathionine into homocysteine; may be redox regulated by Gto1p; involved in the release of the aromatic thiol 3-mercaptohexanol during wine fermentation" /db_xref="GeneID:852691" /db_xref="SGD:S000003152" ORIGIN 1 mpikrldtvv vntgsqndqh sasvppvyls ttfkvdlnne daqnydysrs gnptrsvlqh 61 qigklyrvpq envlavssgm taldvilrgl vllngtdnht ptiiagddly ggtqrllnff 121 kqqshavsvh vdtsdfekfk tvfqsldkvd cvllesptnp lckvvdipri lrfvkcispd 181 ttvvvdntmm sglncnplql npgcdvvyes atkylnghhd lmggviiskt peiasklyfv 241 instgaglsp mdswllvrgl ktlgvrlyqq qrnamilahw lenscgfkpt rtnkatktrf 301 vglrsnpdfk lhksfnngpg avlsfetgsf ehskrlvssk klsiwavtvs fgcvnsllsm 361 pckmshasid pelrkerdfp edlvrlccgi enivdlkkdl laamvdadii evrengkylf 421 nklnknlavn ttiddlhkpl siyeefynqd lirkdselni ksskl // LOCUS NP_011332 219 aa linear PLN 30-JUN-2025 DEFINITION Mnd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011332 VERSION NP_011332.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181048.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07932. On Jan 21, 2003 this sequence version replaced NP_011332.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..219 /product="Mnd1p" /calculated_mol_wt="25952" Region 8..219 /region_name="COG5124" /note="Protein predicted to be involved in meiotic recombination [Cell division and chromosome partitioning / General function prediction only]" /db_xref="CDD:227453" CDS 1..219 /gene="MND1" /locus_tag="YGL183C" /coded_by="NM_001181048.1:1..660" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:11940665]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:15249670]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:16581767|PMID:11470404]" /note="Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks" /db_xref="GeneID:852692" /db_xref="SGD:S000003151" ORIGIN 1 mgpkrqtvsl qekknrilnf fqetytfyni keleksipkk cgispmivkd lvqqmidedg 61 visvekcgni niywcfknqt lqklydssel ikkkiqevkc diatykqeld ktlatgrrkk 121 ftvgqksynr eallekrkki qdeikkksns lqkiesirwd aakiqenkqq irlkkvhlek 181 ttdnieilid ylykkfflkp eqirkefgip eefkeftev // LOCUS NP_011334 396 aa linear PLN 30-JUN-2025 DEFINITION Gts1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011334 VERSION NP_011334.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181046.1 REFERENCE 1 (residues 1 to 396) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 396) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 396) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 396) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07933. Method: conceptual translation. FEATURES Location/Qualifiers source 1..396 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..396 /product="Gts1p" /calculated_mol_wt="44276" Region 8..310 /region_name="COG5347" /note="GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]" /db_xref="CDD:227651" CDS 1..396 /gene="GTS1" /locus_tag="YGL181W" /gene_synonym="FHT1; LSR1" /coded_by="NM_001181046.1:1..1191" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17449140|PMID:11549884]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:17449140]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:18208507]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:17449140]" /experiment="EXISTENCE:mutant phenotype:GO:0010512 negative regulation of phosphatidylinositol biosynthetic process [PMID:18208507]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12782635]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16911513]" /experiment="EXISTENCE:physical interaction:GO:0140297 DNA-binding transcription factor binding [PMID:16911513]" /note="Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated) domain; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations" /db_xref="GeneID:852694" /db_xref="SGD:S000003149" ORIGIN 1 mrfrssshsl khvdrelkel inssenankc gecgnfyptw csvnlgvflc grcasvhrkv 61 fgsrdddafs nvkslsmdrw tredidelvs lggnkgnarf wnpknvpfpf dgdddkaive 121 hyirdkyilg kfrydeikpe dfgsrmddfd gesdrfdern rsrsrsrshs fykgghnrsd 181 yggsrdsfqs sgsrysrqla elkdmgfgdt nknldalssa hgninraidy lekssssrns 241 vsaaattstp plprrratts gpqpaifdgt nvitpdftsn sasfvqakpa vfdgtlqqyy 301 dpatgmiyvd qqqyamamqq qqqqqqqlav aqaqaqaqaq aqaqvqaqaq aqaqaqaqaq 361 qiqmqqlqmq qqqqaplsfq qmsqggnlpq gyfytq // LOCUS NP_011335 897 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase ATG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011335 VERSION NP_011335.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181045.1 REFERENCE 1 (residues 1 to 897) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 897) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 897) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 897) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07934. Method: conceptual translation. FEATURES Location/Qualifiers source 1..897 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..897 /product="serine/threonine protein kinase ATG1" /EC_number="2.7.11.1" /calculated_mol_wt="101587" Region 30..324 /region_name="STKc_ATG1_ULK_like" /note="Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like kinases; cd14009" /db_xref="CDD:270911" Site order(30..34,38,52,54,86,102..105,109,111,172,174,176..177, 179,211,214,229..232) /site_type="active" /db_xref="CDD:270911" Site order(30..34,38,52,54,86,102..105,109,172,174,176..177,179, 211) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270911" Site order(34,109,111,172,174,176,214,229..232) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270911" Site order(210..218,223..232) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270911" Region 586..893 /region_name="DUF3543" /note="Domain of unknown function (DUF3543); pfam12063" /db_xref="CDD:463451" CDS 1..897 /gene="ATG1" /locus_tag="YGL180W" /gene_synonym="APG1; AUT3; CVT10" /coded_by="NM_001181045.1:1..2694" /experiment="EXISTENCE:direct assay:GO:0000045 autophagosome assembly [PMID:18725539]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:11689437|PMID:18497569|PMID:15659643]" /experiment="EXISTENCE:direct assay:GO:0000421 autophagosome membrane [PMID:22885598]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:33536246|PMID:25921291|PMID:9224897|PMID:22885598]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:9190802]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:18725539]" /experiment="EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:1990316 Atg1/ULK1 kinase complex [PMID:26753620]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:22778255|PMID:9224897]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:9224897]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:23382696]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:33536246]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:32788210]" /experiment="EXISTENCE:mutant phenotype:GO:0018105 peptidyl-serine phosphorylation [PMID:33536246]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:10995454|PMID:12589048]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:33536246]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0051365 cellular response to potassium ion starvation [PMID:32788210]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]" /experiment="EXISTENCE:physical interaction:GO:1990316 Atg1/ULK1 kinase complex [PMID:15743910]" /note="Protein serine/threonine kinase; required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; forms a complex with Atg13p and Atg17p during autophagy; required for re-phosphorylation of Atg13p during termination of autophagy, following prolonged nitrogen starvation; essential for cell cycle progression from G2/M to G1 under nitrogen starvation" /db_xref="GeneID:852695" /db_xref="SGD:S000003148" ORIGIN 1 mgdiknkdht tsvnhnlmas agnytaekei gkgsfatvyr ghltsdksqh vaikevsrak 61 lknkkllenl eieiailkki khphivglid certstdfyl imeycalgdl tfllkrrkel 121 menhpllrtv fekypppsen hnglhrafvl sylqqlasal kflrsknlvh rdikpqnlll 181 stpligyhds ksfhelgfvg iynlpilkia dfgfarflpn tslaetlcgs plymapeiln 241 yqkynakadl wsvgtvvfem ccgtppfras nhlelfkkik randvitfps ycniepelke 301 licslltfdp aqrigfeeff ankvvnedls syeleddlpe leskskgive snmfvseyls 361 kqpkspnsnl aghqsmadnp aelsdalkns niltapavkt dhtqavdkka snnkyhnslv 421 sdrsfereyv vvekksvevn sladevaqag fnpnpikhpt stqnqnvlln eqfspnnqqy 481 fqnqgenprl lratssssgg sdgsrrpslv drrlsissln psnalsralg iastrlfgga 541 nqqqqqqqit ssppysqtll nsqlfhelte niilridhlq hpetlkldnt nivsilesla 601 akafvvysya evkfsqivpl sttlkgmanf enrrsmdsna iaeeqdsdda eeedetlkky 661 kedclstktf gkgrtlsats qlsatfnklp rsemillcne aivlymkals ilsksmqvts 721 nwwyesqeks cslrvnvlvq wlrekfnecl ekadflrlki ndlrfkhase vaenqtleek 781 gsseepvyle kllydralei skmaahmelk genlyncela yatslwmlet slddddftna 841 ygdypfktni hlksndvedk ekyhsvlden driiirkyid sianrlkilr qkmnhqn // LOCUS NP_011336 560 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase TOS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011336 VERSION NP_011336.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181044.3 REFERENCE 1 (residues 1 to 560) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 560) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 560) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 560) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07935. On Jul 30, 2012 this sequence version replaced NP_011336.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..560 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..560 /product="serine/threonine protein kinase TOS3" /EC_number="2.7.11.1" /calculated_mol_wt="61960" Region 56..344 /region_name="STKc_LKB1_CaMKK" /note="Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins; cd14008" /db_xref="CDD:270910" Site order(56..60,64,77,79,117,135..138,142,144,189,191, 193..194,196,207,210,235..238) /site_type="active" /db_xref="CDD:270910" Site order(56..60,64,77,79,117,135..138,142,189,191,193..194, 196,207) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270910" Site order(60,142,144,189,191,193,210,235..238) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270910" Site order(206..215,223..224,234..238) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270910" CDS 1..560 /gene="TOS3" /locus_tag="YGL179C" /coded_by="NM_001181044.3:1..1683" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:16201971|PMID:12847291]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15879520|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:15340085]" /experiment="EXISTENCE:mutant phenotype:GO:1900180 regulation of protein localization to nucleus [PMID:15340085]" /note="Protein kinase; related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; localizes to cytosol and peroxisomes; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; TOS3 has a paralog, SAK1, that arose from the whole genome duplication" /db_xref="GeneID:852696" /db_xref="SGD:S000003147" ORIGIN 1 mvllkepvqp lprssllynn asnsssrike trkvkllynp ltkrqilnnf eilatlgngq 61 ygkvklardl gtgalvaiki lnrfekrsgy slqlkvenpr vnqeievmkr chhenvvely 121 eilndpestk vylvleycsr gpvkwcpenk meikavgpsi ltfqqsrkvv ldvvsgleyl 181 hsqgithrdi kpsnllissn gtvkisdfgv amstatgstn iqssheqllk sralgtpaff 241 apelcsteke yscssaidiw slgvtiycll fgklpfnans glelfdsiin kplefpsyee 301 mlngatsgit meeytdakdl lkkllqkdpd krikladikv hpfmchygks daasvltnle 361 tfhelkvspp ssckrvelvs lpvnssfasl dsvymenfdh nnlrtgadrn styspsiyda 421 ntlspsayhn igsressyss fssftsstaf asqisiqdap aigdqqclig esgsslrvns 481 cefpqyttms pvgeypfest easlsstltp vgnvpqrika hlvegksnsk ddlrieadas 541 lvfeasdaqr trrrmslykl // LOCUS NP_011337 859 aa linear PLN 30-JUN-2025 DEFINITION Mpt5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011337 VERSION NP_011337.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181043.1 REFERENCE 1 (residues 1 to 859) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 859) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 859) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 859) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07936. Method: conceptual translation. FEATURES Location/Qualifiers source 1..859 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..859 /product="Mpt5p" /calculated_mol_wt="95292" Region 49..848 /region_name="COG5099" /note="RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]" /db_xref="CDD:227430" CDS 1..859 /gene="MPT5" /locus_tag="YGL178W" /gene_synonym="HTR1; PUF5; UTH4" /coded_by="NM_001181043.1:1..2580" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640|PMID:11157761]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:20498834|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:20427513]" /experiment="EXISTENCE:direct assay:GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:16715093]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:29297464]" /experiment="EXISTENCE:mutant phenotype:GO:1902416 positive regulation of mRNA binding [PMID:22890846]" /experiment="EXISTENCE:mutant phenotype:GO:1903450 regulation of G1 to G0 transition [PMID:31141453]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:20705650|PMID:16715093]" /experiment="EXISTENCE:physical interaction:GO:0045947 negative regulation of translational initiation [PMID:20705650]" /note="mRNA-binding protein of the PUF family; binds to specific mRNAs, often in the 3' UTR; has broad specificity and binds to more than 1000 mRNAs (16% of the transcriptome); recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity" /db_xref="GeneID:852697" /db_xref="SGD:S000003146" ORIGIN 1 minnepfpsa dsasilttst snnslmsynh qpqlsinsvq sllepvtppp lgqmnnkrnh 61 qkahsldlsg fnqfisstqs plalmnntst snsansfspn pnaasnstgl sasmanppai 121 lplinefdle mdgprrkssh dftvvapsns gvntsslime tpsssvtpaa slrnfsnsnn 181 aaskcgvdns sfglssstss smveisalpl rdldyiklat dqfgcrflqk kletpsesnm 241 vrdlmyeqik pffldlildp fgnylvqklc dyltaeqktl liqtiypnvf qisinqygtr 301 slqkiidtvd nevqidliik gfsqeftsie qvvtlindln gnhviqkcif kfspskfgfi 361 idaiveqnni itisthkhgc cvlqkllsvc tlqqifkisv kivqflpgli ndqfgnyiiq 421 flldikeldf yllaelfnrl snelcqlscl kfssnvvekf ikklfriitg fivnnnggas 481 qrtavasddv inasmnillt tidiftvnln vlirdnfgny alqtlldvkn yspllaynkn 541 snaigqnsss tlnygnfcnd fslkignliv ltkellpsik ttsyakkikl kvkayaeatg 601 ipftdispqv tamshnnlqt innenknphn knshnhnhnh nhnhahnnnn nnnqkshtrh 661 fslpanayhr rsnssvtnnf snqyaqdqki hspqqimnfn qnaypsmgap sfnsqtnppl 721 vshnslqnfd nrqfanlmah pnsaapihsf sssnitnvnp nvsrgfkqpg fmmnetdkin 781 anhfspysna nsqnfnesfv prmqyqtega nwdsslsmks qhigqgpynq vnmsrnasis 841 nmpamntart sdelqftlp // LOCUS NP_011339 554 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL176C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011339 VERSION NP_011339.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181041.1 REFERENCE 1 (residues 1 to 554) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 554) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 554) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07937. Method: conceptual translation. FEATURES Location/Qualifiers source 1..554 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..554 /product="uncharacterized protein" /calculated_mol_wt="63145" CDS 1..554 /locus_tag="YGL176C" /coded_by="NM_001181041.1:1..1665" /note="hypothetical protein; contributes to high inhibitor stress tolerance; deletion mutant is viable" /db_xref="GeneID:852699" /db_xref="SGD:S000003144" ORIGIN 1 mtpnlpgfyy drerrryfri senqsisttg ttnqyrkdni krqcveenyd kkfsmikkkr 61 qqtlqkykls llnplerafr plsyekymig lnmqyashsl teghhshssa nvkslnfphr 121 iqigvlanci llvtqegcfh sklvfatnkg yvagfssldn fseenfftgf smaelnpmlk 181 ykseptdvfk tmklertvai kegpshyfyh nvntrsnvht faiflqdfss lkllkirqvk 241 lkencqvhds lvvgdtliit vnyrchfydl ipetfpnpyi fspakssrkh ksrsditsls 301 fclqedalsp lkktntgvfy lgyrngdsma ivftnitnmt lqysktngmt sesrnqpirn 361 slksvvsika lnnkglilis gmadkenvqq lviadtfled ilteipvvsf ktkflnvtkd 421 teileisddg ryfiygstsa rdgkgdfevf cttlsgnldy ekseggnitl ypiggmknyc 481 rlenfqfesi hlhsafippr yvnpfdavep lgeesstspy dipeealsqk icilirredd 541 pynganifit salt // LOCUS NP_011340 345 aa linear PLN 30-JUN-2025 DEFINITION ssDNA endodeoxyribonuclease SAE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011340 VERSION NP_011340.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181040.1 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07938. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..345 /product="ssDNA endodeoxyribonuclease SAE2" /calculated_mol_wt="39966" Region <264..280 /region_name="SAE2" /note="DNA endonuclease activator SAE2/CtIP C-terminus; pfam08573" /db_xref="CDD:462525" CDS 1..345 /gene="SAE2" /locus_tag="YGL175C" /gene_synonym="COM1" /coded_by="NM_001181040.1:1..1038" /experiment="EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:18042458]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:18042458]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006308 DNA catabolic process [PMID:18042458]" /experiment="EXISTENCE:direct assay:GO:0030870 Mre11 complex [PMID:25231868]" /experiment="EXISTENCE:genetic interaction:GO:0000706 meiotic DNA double-strand break processing [PMID:20150422]" /experiment="EXISTENCE:genetic interaction:GO:0000729 DNA double-strand break processing [PMID:18806779]" /experiment="EXISTENCE:genetic interaction:GO:0042138 meiotic DNA double-strand break formation [PMID:22745819]" /experiment="EXISTENCE:mutant phenotype:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:18042458]" /experiment="EXISTENCE:mutant phenotype:GO:0000706 meiotic DNA double-strand break processing [PMID:9215888]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:19595717]" /experiment="EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:26490958]" /experiment="EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:18042458]" /experiment="EXISTENCE:mutant phenotype:GO:0006308 DNA catabolic process [PMID:18042458]" /experiment="EXISTENCE:mutant phenotype:GO:0007534 gene conversion at mating-type locus [PMID:18806779]" /experiment="EXISTENCE:mutant phenotype:GO:0010791 DNA double-strand break processing involved in repair via synthesis-dependent strand annealing [PMID:23254329]" /experiment="EXISTENCE:mutant phenotype:GO:0031860 telomeric 3' overhang formation [PMID:19595717]" /note="Endonuclease required for telomere elongation; required for telomeric 5' C-rich strand resection; involved in ds-break repair and processing hairpin DNA structures with the MRX complex; function requires sumoylation and phosphorylation; exists as inactive oligomers that are transiently released into smaller active units by phosphorylation; DNA damage triggers Sae2p removal, so active Sae2p is present only transiently; sequence and functional similarity with human CtIP/RBBP8" /db_xref="GeneID:852700" /db_xref="SGD:S000003143" ORIGIN 1 mvtgeenvyl ksslsilkel sldellnvqy dvttliakrv qalqnrnkcv leepnsklae 61 ilcheknapq qssqtsagpg eqdsedfilt qfdedikkes aevhyrnenk htvqlplvtm 121 ppnrhkrkis efssplngln nlsdledcsd tvihekdndk enktrkllgi elenpestsp 181 nlyknvkdnf lfdfntnplt krawiledfr pnediapvkr grrklerfya qvgkpedskh 241 rslsvviesq nsdyefafdn lrnrsksppg fgrldfpstq egnedkkksq eiirrktkyr 301 flmasnnkip pyereyvfkr eqlnqivddg cffwsdkllq iyarc // LOCUS NP_011341 266 aa linear PLN 30-JUN-2025 DEFINITION Bud13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011341 VERSION NP_011341.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181039.3 REFERENCE 1 (residues 1 to 266) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 266) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 266) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 266) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07939. On Jul 30, 2012 this sequence version replaced NP_011341.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..266 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..266 /product="Bud13p" /calculated_mol_wt="30341" Region 120..250 /region_name="Bud13" /note="Pre-mRNA-splicing factor of RES complex; pfam09736" /db_xref="CDD:462867" CDS 1..266 /gene="BUD13" /locus_tag="YGL174W" /gene_synonym="CWC26" /coded_by="NM_001181039.3:1..801" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:15565172]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11452010]" /experiment="EXISTENCE:direct assay:GO:0070274 RES complex [PMID:15565172]" /note="Subunit of the RES complex; RES complex is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern due to a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids" /db_xref="GeneID:852701" /db_xref="SGD:S000003142" ORIGIN 1 malhqylset ygptkpknkt kkkkkesksd ansdktsliv kerlstlqqe qeksgvasfs 61 kfdkqkskni wknletnels haithpsass itgneskndl keiraqeplv tvadksktrk 121 tiyrdaqghk iqedskidds sfsrskyede kaaereqylk nlnmgdvqkl ginvdahdkk 181 knqtasslti edpaitfthd kertvktsll grklydkpap enrfaimpgs rwdgvhrsng 241 feekwfakqn einekkvqsy tlqedy // LOCUS NP_011342 1528 aa linear PLN 30-JUN-2025 DEFINITION chromatin-binding exonuclease XRN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011342 VERSION NP_011342.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181038.1 REFERENCE 1 (residues 1 to 1528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1528) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07940. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1528 /product="chromatin-binding exonuclease XRN1" /calculated_mol_wt="175329" Region 1..955 /region_name="XRN1" /note="5'-3' exonuclease [Replication, recombination and repair]; COG5049" /db_xref="CDD:227382" Region 918..1005 /region_name="XRN1_D2_D3" /note="Exoribonuclease Xrn1 D2/D3 domain; pfam18334" /db_xref="CDD:436419" Region 1087..1156 /region_name="Xrn1_D3" /note="Exoribonuclease 1 Domain-3; pfam18194" /db_xref="CDD:465674" Region 1163..1233 /region_name="SH3_12" /note="Xrn1 SH3-like domain; pfam18129" /db_xref="CDD:465661" CDS 1..1528 /gene="XRN1" /locus_tag="YGL173C" /gene_synonym="DST2; KEM1; RAR5; SEP1; SKI1" /coded_by="NM_001181038.1:1..4587" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:25811606|PMID:12730603]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004534 5'-3' RNA exonuclease activity [PMID:3545079]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23706738|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0016078 tRNA decay [PMID:21632824]" /experiment="EXISTENCE:direct assay:GO:0031370 eukaryotic initiation factor 4G binding [PMID:30899024]" /experiment="EXISTENCE:direct assay:GO:0090512 eisosome membrane domain/MCC [PMID:25811606]" /experiment="EXISTENCE:direct assay:GO:0110155 NAD-cap decapping [PMID:35173156]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:9488433]" /experiment="EXISTENCE:genetic interaction:GO:0043144 sno(s)RNA processing [PMID:9488433]" /experiment="EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:10848586]" /experiment="EXISTENCE:mutant phenotype:GO:0000932 P-body [PMID:12730603]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:24119399]" /experiment="EXISTENCE:mutant phenotype:GO:0004534 5'-3' RNA exonuclease activity [PMID:1979303]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9488433]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:30899024]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:29465287]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:16240118]" /experiment="EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:29465287]" /experiment="EXISTENCE:mutant phenotype:GO:0032204 regulation of telomere maintenance [PMID:28160602]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:23706738]" /experiment="EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:33258404|PMID:23706738]" /experiment="EXISTENCE:mutant phenotype:GO:0061157 mRNA destabilization [PMID:24567736]" /experiment="EXISTENCE:mutant phenotype:GO:0070479 nuclear-transcribed mRNA catabolic process, 5'-3' exonucleolytic nonsense-mediated decay [PMID:30874502]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]" /experiment="EXISTENCE:mutant phenotype:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:31913314]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:33258404]" /note="Evolutionarily-conserved 5'-3' exonuclease; deNADing enzyme that modulates mitochondrial NAD-capped RNA; component of cytoplasmic P-bodies involved in mRNA decay; positively regulates transcription initiation and elongation; involved in microtubule-mediated processes, filamentous growth, rRNA maturation, telomere maintenance, tRNA intron turnover; negative regulator of autophagy; activated by glycolytic flux and scavenger decapping enzyme Dcs1p; role in preventing L-A mycovirus pathogenesis" /db_xref="GeneID:852702" /db_xref="SGD:S000003141" ORIGIN 1 mgipkffryi serwpmilql iegtqipefd nlyldmnsil hncthgnddd vtkrlteeev 61 fakictyidh lfqtikpkki fymaidgvap rakmnqqrar rfrtamdaek alkkaiengd 121 eipkgepfds nsitpgtefm akltknlqyf ihdkisndsk wrevqiifsg hevpgegehk 181 imnfirhlks qkdfnqntrh ciygldadli mlglsthgph fallreevtf grrnsekksl 241 ehqnfyllhl sllreymele fkeiademqf eynferildd filvmfvign dflpnlpdlh 301 lnkgafpvll qtfkeallht dgyinehgki nlkrlgvwln ylsqfellnf ekddidvewf 361 nkqlenisle gerkrqrvgk kllvkqqkkl igsikpwlme qlqeklspdl pdeeiptlel 421 pkdldmkdhl eflkefafdl glfithsksk gsyslkmdld sinpdeteee fqnrvnsirk 481 tikkyqnaii vedkeelete ktiynerfer wkheyyhdkl kfttdseekv rdlakdyveg 541 lqwvlyyyyr gcpswswyyp hhyaprisdl akgldqdief dlskpftpfq qlmavlpers 601 knlippafrp lmydeqspih dfypaevqld kngktadwea vvlisfvdek rlieamqpyl 661 rklspeektr nqfgkdliys fnpqvdnlyk splggifsdi ehnhcvekey itipldssei 721 rygllpnakl gaemlagfpt llslpftssl eynetmvfqq pskqqsmvlq itdiyktnnv 781 tledfskrhl nkviytrwpy lresklvslt dgktiyeyqe sndkkkfgfi tkpaetqdkk 841 lfnslknsml rmyakqkavk igpmeaiatv fpvtglvrds dggyiktfsp tpdyyplqlv 901 vesvvneder ykergpipie eefplnskvi flgdyaygge ttidgyssdr rlkitvekkf 961 ldseptigke rlqmdhqavk yypsyivskn mhlhplflsk itskfmitda tgkhinvgip 1021 vkfearhqkv lgyarrnprg weysnltlnl lkeyrqtfpd fffrlskvgn dipvledlfp 1081 dtstkdamnl ldgikqwlky vsskfiavsl esdsltktsi aavedhimky aaniegherk 1141 qlakvpreav lnprssfall rsqkfdlgdr vvyiqdsgkv pifskgtvvg yttlssslsi 1201 qvlfdheiva gnnfggrlrt nrglgldasf llnitnrqfi yhskaskkal ekkkqsnnrn 1261 nntktahktp skqqseeklr kerahdllnf ikkdtnekns esvdnksmgs qkdskpakkv 1321 llkrpaqkss envqvdlanf ekapldnptv agsifnavan qysdgigsnl niptpphpmn 1381 vvggpipgan dvadvglpyn ippgfmthpn glhplhphqm pypnmngmsi pppaphgfgq 1441 pisfpppppm tnvsdqgsri vvnekesqdl kkfingkqhs ngstiggetk nsrkgeikps 1501 sgtnstecqs pksqsnaadr dnkkdest // LOCUS NP_011343 472 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin NUP49 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011343 VERSION NP_011343.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181037.1 REFERENCE 1 (residues 1 to 472) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 472) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 472) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 472) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07941. Method: conceptual translation. FEATURES Location/Qualifiers source 1..472 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..472 /product="FG-nucleoporin NUP49" /calculated_mol_wt="49011" Region 29..>289 /region_name="Nucleoporin_FG2" /note="Nucleoporin FG repeated region; pfam15967" /db_xref="CDD:435043" Region <267..465 /region_name="V_Alix_like" /note="Protein-interacting V-domain of mammalian Alix and related domains; cl14654" /db_xref="CDD:353824" Site order(283,287,290..291,443,446..447,450,452) /site_type="other" /note="putative YPXnL-motif binding site" /db_xref="CDD:185746" CDS 1..472 /gene="NUP49" /locus_tag="YGL172W" /gene_synonym="NSP49" /coded_by="NM_001181037.1:1..1419" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:1385442|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0017056 structural constituent of nuclear pore [PMID:19680227]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:9813081|PMID:18046406|PMID:24574455]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:11387327]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:9971735|PMID:11071906]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:8524308]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:7813444]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:7813444]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788]" /note="FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup57p)" /db_xref="GeneID:852703" /db_xref="SGD:S000003140" ORIGIN 1 mfglnkasst pagglfgqas gastgnantg fsfggtqtgq ntgpstgglf gakpagstgg 61 lgasfgqqqq qsqtnafggs attggglfgn kpnntantgg glfgansnsn sgslfgsnna 121 qtsrglfgnn ntnninnsss gmnnasaglf gskpaggtsl fgntstssap aqnqgmfgak 181 pagtslfgnn agntttgggl fgskptgats lfgssnnnnn nnnsnnimsa sgglfgnqqq 241 qlqqqpqmqc alqnlsqlpi tpmtriselp pqirqeieql dqyiqkqvqi shhlkadtid 301 hdelidsipr dvayllkses atsqylkqdl kkissfksli dedlldtqtf svllqqlltp 361 gskissndld kffqkkihly ekkledycri lsdietavng idtdlfgapn npnstaitad 421 lgsseaenll qlktglaaiv stvieeftlf mdiaeriavl hqktktlasl si // LOCUS NP_011344 564 aa linear PLN 30-JUN-2025 DEFINITION RNA-dependent ATPase ROK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011344 VERSION NP_011344.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181036.1 REFERENCE 1 (residues 1 to 564) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 564) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 564) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 564) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07942. Method: conceptual translation. FEATURES Location/Qualifiers source 1..564 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..564 /product="RNA-dependent ATPase ROK1" /EC_number="3.6.4.13" /calculated_mol_wt="63522" Region 119..560 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" Region 133..336 /region_name="DEADc_DDX52" /note="DEAD-box helicase domain of DEAD box protein 52; cd17957" /db_xref="CDD:350715" Site order(142,144..146,149,167..174,280) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350715" CDS 1..564 /gene="ROK1" /locus_tag="YGL171W" /coded_by="NM_001181036.1:1..1695" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23153376]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9154839]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:18975973|PMID:23153376]" /experiment="EXISTENCE:direct assay:GO:0030490 maturation of SSU-rRNA [PMID:23630256]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9154839]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9154839]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9154839]" /experiment="EXISTENCE:mutant phenotype:GO:0048254 snoRNA localization [PMID:18833290]" /note="RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation" /db_xref="GeneID:852704" /db_xref="SGD:S000003139" ORIGIN 1 mdifrvltrg asvkkesgpk akaadysvin gndenhkedn nesqivkeld ffrnkriisk 61 veddrektte ndspnkeeks gnddglikpv itntveasal rksykgnvsg idiplpigsf 121 edlisrfsfd krllnnlien gfteptpiqc ecipvalnnr dvlacgptgs gktlaflipl 181 vqqiiddkqt aglkgliisp tkelanqifi ecfklsykif lekkrplqva llskslgakl 241 knkvvsdkky diiistplrl idvvkneald lskvkhlifd eadklfdktf veqsddilsa 301 crepslrkam fsatipsnve eiaqsimmdp vrviighkea antnieqkli fcgneegkli 361 airqlvqege fkppiiifle sitrakalyh elmydrinvd vihaertalq rdriierfkt 421 gelwclictd vlargidfkg vnlvinydvp gssqayvhri grtgrggrsg kaitfytkqd 481 svaikpiinv mkqsgcevse wmdkmakmtr kekesikngk ahkerkqitt vpkmdkakrr 541 rqqemiaask rrkneelskk hfsk // LOCUS NP_011345 413 aa linear PLN 30-JUN-2025 DEFINITION Spo74p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011345 VERSION NP_011345.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181035.3 REFERENCE 1 (residues 1 to 413) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 413) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 413) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 413) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07943. On Jul 30, 2012 this sequence version replaced NP_011345.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..413 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..413 /product="Spo74p" /calculated_mol_wt="47569" CDS 1..413 /gene="SPO74" /locus_tag="YGL170C" /coded_by="NM_001181035.3:1..1242" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12796288]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0035974 meiotic spindle pole body [PMID:12796288]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12796288]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0035974 meiotic spindle pole body [PMID:12796288]" /note="Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation" /db_xref="GeneID:852705" /db_xref="SGD:S000003138" ORIGIN 1 mgagtllngl ekenfpnnih sdlpaypnmd sqedgntske skrnspvkqk sqkdeekssk 61 mgtasnifhe nkdiherseh tddfndglkl apdsspslke cqfknwesfw cntegyktkh 121 mqpfhftsgl eeikepvmel nistspykgq rpnsapteys aattaftktq levsflktnl 181 ltyikkeidi clssvpffdd avqmqkkfle yrdidldeey elkilgelln dlnffhmqen 241 sllnrelavr rfsnqpesqn lpsirdfrnp llpidnrpsp plglkrngks feetydftsn 301 tsnfwgekae lqnsitggtp yffhpnnihq tkpfmsfenq nellfqrkns dykqhfnsgr 361 nihngvesks yrgvglndsy qkgyaamtks fgnidlnrmp rrsneemysw srn // LOCUS NP_011346 426 aa linear PLN 30-JUN-2025 DEFINITION threonylcarbamoyladenylate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011346 VERSION NP_011346.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181034.1 REFERENCE 1 (residues 1 to 426) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 426) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 426) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 426) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07944. Method: conceptual translation. FEATURES Location/Qualifiers source 1..426 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..426 /product="threonylcarbamoyladenylate synthase" /EC_number="2.7.7.87" /calculated_mol_wt="46407" Region 48..257 /region_name="TsaC" /note="tRNA A37 threonylcarbamoyladenosine synthetase subunit TsaC/SUA5/YrdC [Translation, ribosomal structure and biogenesis]; COG0009" /db_xref="CDD:439780" Region 253..420 /region_name="Sua5_C" /note="Threonylcarbamoyl-AMP synthase, C-terminal domain; pfam03481" /db_xref="CDD:460941" CDS 1..426 /gene="SUA5" /locus_tag="YGL169W" /coded_by="NM_001181034.1:1..1281" /experiment="EXISTENCE:direct assay:GO:0002949 tRNA threonylcarbamoyladenosine modification [PMID:23620299]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25038083]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:19369944]" /experiment="EXISTENCE:direct assay:GO:0061710 L-threonylcarbamoyladenylate synthase [PMID:23620299]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:19369944]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:19884342]" /experiment="EXISTENCE:mutant phenotype:GO:0070525 tRNA threonylcarbamoyladenosine metabolic process [PMID:21183954|PMID:19287007]" /note="Protein involved in threonylcarbamoyl adenosine biosynthesis; Sua5p and Qri7p are necessary and sufficient for RNA t6A modification in vitro; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family; binds single-stranded telomeric DNA and null mutant has abnormal telomere length" /db_xref="GeneID:852707" /db_xref="SGD:S000003137" ORIGIN 1 mylgrhflam tskalfdtki lkvnplsiif spdahidgsl ptitdpetea alveaariir 61 dtdetvafpt etvyglggsa lndnsvlsiy raknrpsdnp lithvssidq lnrkvfnqph 121 lsgtslfdni psiyrpliss lwpgpltill pvpssehsal sklttadqpt favripanpv 181 aralialsdt piaapsanas trpsptlash vyhdlkdkip iildggackv gvestvvdgl 241 cnpptllrpg gftyeeivkl ggeawslckv enkktvekge kvrtpgmkyr hyspsakvvl 301 lvphcegdgi lkgvdrmerl krlietelka nsnikkiail tslklrdsdl qskifnepdf 361 ssktfiierl gqsgeeiqtn lfaalrkvde ndkvdlifve gineegegla vmnrlrkaaa 421 nnciqf // LOCUS NP_011347 110 aa linear PLN 30-JUN-2025 DEFINITION Hur1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011347 VERSION NP_011347.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181033.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07945. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..110 /product="Hur1p" /calculated_mol_wt="12384" CDS 1..110 /gene="HUR1" /locus_tag="YGL168W" /coded_by="NM_001181033.1:1..333" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:12615994]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:28987344]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0035825 homologous recombination [PMID:28987344]" /note="Protein with a role in DNA repair; mutants show reduced efficiency of non-homologous end-joining repair" /db_xref="GeneID:852708" /db_xref="SGD:S000003136" ORIGIN 1 mfilvsvvni ctyihlhmfp listftsigl gvlmkdkgke gktikaqnvt yqtfekyves 61 ssffflvhnf lnsstmktll lmsnnnsise ipsfsvlkil wkngiyiahi // LOCUS NP_011348 950 aa linear PLN 30-JUN-2025 DEFINITION Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011348 VERSION NP_011348.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181032.1 REFERENCE 1 (residues 1 to 950) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 950) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 950) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 950) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07946. Method: conceptual translation. FEATURES Location/Qualifiers source 1..950 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..950 /product="Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1" /EC_number="7.2.2.10" /calculated_mol_wt="104440" Region 35..940 /region_name="ATPase-IIA2_Ca" /note="golgi membrane calcium-translocating P-type ATPase; TIGR01522" /db_xref="CDD:130585" CDS 1..950 /gene="PMR1" /locus_tag="YGL167C" /gene_synonym="BSD1; LDB1; SSC1" /coded_by="NM_001181032.1:1..2853" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:9092527|PMID:24124599]" /experiment="EXISTENCE:direct assay:GO:0005388 P-type calcium transporter activity [PMID:10545175]" /experiment="EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:10545175]" /experiment="EXISTENCE:direct assay:GO:0006816 calcium ion transport [PMID:10545175]" /experiment="EXISTENCE:direct assay:GO:0006828 manganese ion transport [PMID:10801856]" /experiment="EXISTENCE:direct assay:GO:0140613 P-type manganese transporter activity [PMID:10801856]" /experiment="EXISTENCE:genetic interaction:GO:0006874 intracellular calcium ion homeostasis [PMID:23569283]" /experiment="EXISTENCE:genetic interaction:GO:0030026 intracellular manganese ion homeostasis [PMID:29632074]" /experiment="EXISTENCE:mutant phenotype:GO:0005388 P-type calcium transporter activity [PMID:1379856|PMID:10545175]" /experiment="EXISTENCE:mutant phenotype:GO:0006816 calcium ion transport [PMID:10545175]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0030026 intracellular manganese ion homeostasis [PMID:29632074]" /note="High affinity Ca2+/Mn2+ P-type ATPase; required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting, processing; D53A mutant (Mn2+ transporting) is rapamycin sensitive, Q783A mutant (Ca2+ transporting) is rapamycin resistant; Mn2+ transport into Golgi lumen required for rapamycin sensitivity; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease; human ATP2C1 can complement yeast null mutant" /db_xref="GeneID:852709" /db_xref="SGD:S000003135" ORIGIN 1 msdnpfnasl ldedsnrere ildataeals kpspsleyct lsvdealekl dtdkngglrs 61 sneannrrsl ygpneitved deslfkkfls nfiedrmill ligsavvslf mgniddavsi 121 tlaifivvtv gfvqeyrsek slealnklvp aechlmrcgq eshvlastlv pgdlvhfrig 181 dripadirii eaidlsides nltgenepvh ktsqtiekss fndqpnsivp isersciaym 241 gtlvkeghgk givvgtgtnt sfgavfemmn niekpktplq ltmdklgkdl slvsfivigm 301 iclvgiiqgr swlemfqisv slavaaipeg lpiivtvtla lgvlrmakrk aivrrlpsve 361 tlgsvnvics dktgtltsnh mtvsklwcld smsnklnvls ldknkktkns ngnlknylte 421 dvretltign lcnnasfsqe haiflgnptd valleqlanf empdirntvq kvqelpfnsk 481 rklmatkiln pvdnkctvyv kgaferiley stsylkskgk kteklteaqk atinecansm 541 aseglrvfgf akltlsdsst pltedlikdl tftgligmnd pprpnvkfai eqllqggvhi 601 imitgdsent avniakqigi pvidpklsvl sgdkldemsd dqlanvidhv nifaratpeh 661 klnivralrk rgdvvamtgd gvndapalkl sdigvsmgri gtdvakeasd mvltdddfst 721 iltaieegkg ifnniqnflt fqlstsvaal slvalstafk lpnplnamqi lwinilmdgp 781 paqslgvepv dhevmkkppr krtdkilthd vmkrllttaa ciivgtvyif vkemaedgkv 841 tardttmtft cfvffdmfna lacrhntksi feigfftnkm fnyavglsll gqmcaiyipf 901 fqsifktekl gisdilllll isssvfivde lrklwtrkkn eedstyfsnv // LOCUS NP_011349 225 aa linear PLN 30-JUN-2025 DEFINITION Cup2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011349 VERSION NP_011349.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181031.3 REFERENCE 1 (residues 1 to 225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 225) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07947. On Jul 30, 2012 this sequence version replaced NP_011349.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..225 /product="Cup2p" /calculated_mol_wt="24294" Region 2..40 /region_name="Cu_FIST" /note="Copper-Fist; smart00412" /db_xref="CDD:128690" CDS 1..225 /gene="CUP2" /locus_tag="YGL166W" /gene_synonym="ACE1" /coded_by="NM_001181031.3:1..678" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:3052856|PMID:2653812|PMID:2674688]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:3052856]" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:2068093]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2651899]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:3052856]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:2674688]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:29604179]" /experiment="EXISTENCE:mutant phenotype:GO:0046688 response to copper ion [PMID:3043194]" /experiment="EXISTENCE:mutant phenotype:GO:1990169 stress response to copper ion [PMID:29604179]" /note="Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations; required for regulation of copper genes in response to DNA-damaging reagents; CUP2 has a paralog, HAA1, that arose from the whole genome duplication" /db_xref="GeneID:852710" /db_xref="SGD:S000003134" ORIGIN 1 mvvingvkya cetcirghra aqcthtdgpl qmirrkgrps ttcghckelr rtknfnpsgg 61 cmcasarrpa vgskedetrc rcdegepckc htkrkssrks kggschrran deaahvnglg 121 iadldvllgl ngrssdvdmt ttlpslkppl qngeikadsi dnldlasldp leqspsisme 181 pvsinetgsa ytttntalnd idipfsinel nelykqvssh nshsq // LOCUS NP_011351 440 aa linear PLN 30-JUN-2025 DEFINITION Yrb30p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011351 VERSION NP_011351.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181029.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07948. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..440 /product="Yrb30p" /calculated_mol_wt="50165" Region 1..310 /region_name="Ran-binding" /note="RanGTP-binding protein; pfam05508" /db_xref="CDD:428501" CDS 1..440 /gene="YRB30" /locus_tag="YGL164C" /coded_by="NM_001181029.1:1..1323" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12578832]" /experiment="EXISTENCE:direct assay:GO:0030695 GTPase regulator activity [PMID:12578832]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:12578832]" /note="RanGTP-binding protein; inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes" /db_xref="GeneID:852712" /db_xref="SGD:S000003132" ORIGIN 1 mdeilakags qavtfaiksg isiastyalk titnfvvqip kddarridql kfklesrmai 61 vssaidlikl vaargntnlq itlrltkdlk eeidrfdeki nemtqkvegs rsaktqneai 121 kavenyikdl llrieeitpf inlslttsga nlnsalpyql spglllkasd fvsennrkye 181 kamksnekgt gdkeilkvqv gptfevtlfs ifynltsenn gqsgivwked mkrakariyr 241 lnstgrkydy fmkieqdfnd gryhedddke dtpqelaidl nhikklffsv sgkllrleeq 301 dspvlvlkid rsddkeness egdkgllddi twyavsgyea ieedeeedee edeeegkdge 361 erkeeeeeen kledkdssit lleyiirlts lqsndqksil evsderlsiy lndentnsrk 421 drisnstiee tekklknlkl // LOCUS NP_011352 898 aa linear PLN 30-JUN-2025 DEFINITION DNA-dependent ATPase RAD54 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011352 VERSION NP_011352.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181028.1 REFERENCE 1 (residues 1 to 898) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 898) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 898) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 898) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07949. Method: conceptual translation. FEATURES Location/Qualifiers source 1..898 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..898 /product="DNA-dependent ATPase RAD54" /EC_number="3.6.4.12" /calculated_mol_wt="101624" Region 29..246 /region_name="Rad54_N" /note="Rad54 N terminal; pfam08658" /db_xref="CDD:430137" Region <271..806 /region_name="HepA" /note="Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair]; COG0553" /db_xref="CDD:440319" Region 271..554 /region_name="DEXHc_RAD54A" /note="DEXH-box helicase domain of RAD54A; cd18067" /db_xref="CDD:350825" Site order(337..343,381,455..456) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350825" CDS 1..898 /gene="RAD54" /locus_tag="YGL163C" /gene_synonym="XRS1" /coded_by="NM_001181028.1:1..2697" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12577053]" /experiment="EXISTENCE:direct assay:GO:0015616 DNA translocase activity [PMID:10506208|PMID:32502392]" /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:10506208]" /experiment="EXISTENCE:direct assay:GO:0032392 DNA geometric change [PMID:10506208]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:11238918]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:12399378]" /experiment="EXISTENCE:mutant phenotype:GO:0015616 DNA translocase activity [PMID:32502392]" /note="DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; drives ATP-hydrolysis-dependent sequence alignment during homologous recombination; involved in repair of dsDNA breaks during both mitosis and meiosis; promotes strand invasion, catalyzes nucleosome remodeling, and removes Rad51p from dsDNA; member of the SWI/SNF family of DNA translocases; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:852713" /db_xref="SGD:S000003131" ORIGIN 1 marrrlpdrp pngigagerp rlvprpinvq dsvnrltkpf rvpyknthip paagriatgs 61 dnivggrslr krsatvcysg ldinadeaey nsqdisfsql tkrrkdalsa qrlakdptrl 121 shiqytlrrs ftvpikgyvq rhslpltlgm kkkitpeprp lhdptdefai vlydpsvdge 181 mivhdtsmdn keeeskkmik stqekdnink eknsqeerpt qrigrhpalm tngvrnkplr 241 ellgdsensa enkkkfasvp vvidpklaki lrphqvegvr flyrcvtglv mkdyleaeaf 301 ntssedplks dekaltesqk teqnnrgayg cimademglg ktlqcialmw tllrqgpqgk 361 rlidkciivc psslvnnwan elikwlgpnt ltplavdgkk ssmgggnttv sqaihawaqa 421 qgrnivkpvl iisyetlrrn vdqlkncnvg lmladeghrl kngdsltfta ldsiscprrv 481 ilsgtpiqnd lseyfallsf snpgllgsra efrknfenpi lrgrdadatd keitkgeaql 541 qklstivskf iirrtndila kylpckyehv ifvnlkplqn elynkliksr evkkvvkgvg 601 gsqplraigi lkklcnhpnl lnfedefdde ddlelpddyn mpgskardvq tkysakfsil 661 erflhkikte sddkivlisn ytqtldliek mcrykhysav rldgtmsink rqklvdrfnd 721 pegqefifll sskaggcgin liganrlilm dpdwnpaadq qalarvwrdg qkkdcfiyrf 781 istgtieeki fqrqsmkmsl sscvvdaked verlfssdnl rqlfqknent icethetyhc 841 krcnaqgkql krapamlygd attwnhlnhd alektndhll knehhyndis fafqyish // LOCUS NP_011353 299 aa linear PLN 30-JUN-2025 DEFINITION Sut1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011353 VERSION NP_011353.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181027.1 REFERENCE 1 (residues 1 to 299) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 299) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 299) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 299) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07950. Method: conceptual translation. FEATURES Location/Qualifiers source 1..299 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..299 /product="Sut1p" /calculated_mol_wt="33060" CDS 1..299 /gene="SUT1" /locus_tag="YGL162W" /coded_by="NM_001181027.1:1..900" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:11248676]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:23872066]" /experiment="EXISTENCE:genetic interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11401714]" /experiment="EXISTENCE:genetic interaction:GO:1900237 positive regulation of induction of conjugation with cellular fusion [PMID:23872066]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:23223039]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:23223039]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:1900429 negative regulation of filamentous growth of a population of unicellular organisms [PMID:23223039]" /experiment="EXISTENCE:mutant phenotype:GO:2000911 positive regulation of sterol import [PMID:19793923]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11401714]" /note="Zn(II)2Cys6 family transcription factor; positively regulates sterol uptake genes under anaerobic conditions; involved in hypoxic gene expression; represses filamentation-inducing genes during vegetative growth; positively regulates mating with SUT2 by repressing expression of genes that act as mating inhibitors; repressed by STE12; relocalizes from the nucleus to the cytoplasm upon DNA replication stress; SUT1 has a paralog, SUT2, that arose from the whole genome duplication" /db_xref="GeneID:852714" /db_xref="SGD:S000003130" ORIGIN 1 mstsitvrnr drslpplllp nvsllekdir rkgtqnvgit dpellsttwt rkrafptdel 61 lggykrlkpa aadsnecaig iatvtppptl pvsaivpppq nytpplfeyh phalasmvne 121 danasctqms iisrstsnst tssatstssi skrqrsgpsc dkcrlkkikc nakieillqd 181 dtimpmisnk lryvltpddi rlyrgtllrn iaipddvieg tgsrklikhi dklvlltpcl 241 pcikkkhsss stnfpkndkc tfskgftrad inisskislk fkdktiydit yddyksidf // LOCUS NP_011354 310 aa linear PLN 30-JUN-2025 DEFINITION Yip5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011354 VERSION NP_011354.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181026.3 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07951. On Jul 30, 2012 this sequence version replaced NP_011354.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..310 /product="Yip5p" /calculated_mol_wt="34712" Region 115..303 /region_name="Yip1" /note="Yip1 domain; pfam04893" /db_xref="CDD:461468" CDS 1..310 /gene="YIP5" /locus_tag="YGL161C" /coded_by="NM_001181026.3:1..933" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:17178117]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:11943201]" /note="Protein that interacts with Rab GTPases; localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport" /db_xref="GeneID:852715" /db_xref="SGD:S000003129" ORIGIN 1 mpsnnssfld idddlegvdd fgnepnpfdd atvpdspnmn nstagkgsef ynttgskaes 61 aplqgqmdpp aydqvigqnd ndglgrnglr pglinyysky fqidltqfkk rlsavltfrn 121 dhnsesnedn tdlygavwit atvvminftm srglnfiisd viegvktged idrasqfkkl 181 lhsiwlfygy tfgvpfitmq vlnrdehser nrsfksvpel isvygyanli wipvcvilni 241 ldmskrlrtv qaiqwaival gwaqssyfln sqissnnnte tqsngkfsls iivvvalhtl 301 fcllfrfiif // LOCUS NP_011355 570 aa linear PLN 30-JUN-2025 DEFINITION putative metalloreductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011355 VERSION NP_011355.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181025.1 REFERENCE 1 (residues 1 to 570) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 570) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 570) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 570) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07952. Method: conceptual translation. FEATURES Location/Qualifiers source 1..570 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..570 /product="putative metalloreductase" /calculated_mol_wt="65709" Region 101..220 /region_name="Ferric_reduct" /note="Ferric reductase like transmembrane component; pfam01794" /db_xref="CDD:426438" Region 253..365 /region_name="FAD_binding_8" /note="FAD-binding domain; pfam08022" /db_xref="CDD:285293" Site order(287,306..309,322..324,328..329,381) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(306,308..309) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99783" Region 372..556 /region_name="NAD_binding_6" /note="Ferric reductase NAD binding domain; pfam08030" /db_xref="CDD:429792" Site 376..386 /site_type="other" /note="NAD pyrophosphate binding region [chemical binding]" /db_xref="CDD:99783" Site order(376,380..383,385) /site_type="other" /note="beta-alpha-beta stucture motif" /db_xref="CDD:99783" Site order(405..406,409) /site_type="other" /note="NADP ribose binding motif [chemical binding]" /db_xref="CDD:99783" CDS 1..570 /gene="AIM14" /locus_tag="YGL160W" /gene_synonym="YNO1" /coded_by="NM_001181025.1:1..1713" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0097038 perinuclear endoplasmic reticulum [PMID:22586098]" /experiment="EXISTENCE:genetic interaction:GO:0006915 apoptotic process [PMID:22586098]" /experiment="EXISTENCE:mutant phenotype:GO:0016175 superoxide-generating NAD(P)H oxidase activity [PMID:22586098]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:22586098]" /note="NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p" /db_xref="GeneID:852716" /db_xref="SGD:S000003128" ORIGIN 1 mkesplitlv krhsethfan ikygyyvlii slvyliglal lrafgrrtps rsssafknki 61 iyrlydidpa ihlgilffav lipfyyhysl ttqstvylkr lgrlsyalip lnlfltlrpn 121 wflrknctyt dfipfhkwfs riitvigllh giffiikwai ddnvslkqkl ilktfnfagf 181 iisilvlfll icsigpmrry nyrlfyivhn lvnvafillt pihsrpgvkf pflllnctll 241 fihiinrivf akslmilnkn anysktnlvh vrlprailpd yfepgshiri spyrrinply 301 wllpshpyti aslaednsid liiketstae pgsqieslrs npksfhldqe ktytlinsyp 361 psvpeecysq gtniaiicgg sgisfalplf rhffnkenvk ylkmiwlikd yseyelvldy 421 lktngltfek klsnnkrisv fisgeytaet rldeittnid denseyemgs fnnededlsi 481 snfnsenads ndntpetshs ptkengsmie vkskhsftls nelksfnnes aqvnqnetwl 541 fscgppsllq lskkycnder infvcetygl // LOCUS NP_011356 370 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL159W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011356 VERSION NP_011356.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181024.1 REFERENCE 1 (residues 1 to 370) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 370) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 370) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 370) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07953. Method: conceptual translation. FEATURES Location/Qualifiers source 1..370 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..370 /product="uncharacterized protein" /calculated_mol_wt="41504" Region 5..356 /region_name="OCDMu" /note="Ornithine cyclodeaminase/archaeal alanine dehydrogenase, mu-crystallin family [Amino acid transport and metabolism]; COG2423" /db_xref="CDD:441972" CDS 1..370 /locus_tag="YGL159W" /coded_by="NM_001181024.1:1..1113" /note="hypothetical protein; deletion mutant has no detectable phenotype" /db_xref="GeneID:852717" /db_xref="SGD:S000003127" ORIGIN 1 mnnsiitdde vrefylncss qtiiesllsl heslrlysqn heillnrmfk kldetnadsn 61 ishifmpvvs kdfsgikilv nnnnknfqgv inviepetgk ligcfeakqi tairtalasc 121 iglykqlscs hdklfrfeng tcyltcfgtg lqafwhiyia iklimsgivg eslklveini 181 lyhnnmmsld rlkslknlfg snikielnqy qindissegn gavsnsdiif gclptlepnl 241 flrqllnska sveqkhtyis ligsykpvmh ecdkelidkf ksdnesacil vdsrehtlle 301 sgelidsnia phnlieigel dtlkntvlnl nekgckrtit lckivglavm dvalakefls 361 lrtkntenke // LOCUS NP_011357 512 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase RCK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011357 VERSION NP_011357.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181023.1 REFERENCE 1 (residues 1 to 512) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 512) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 512) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 512) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07954. Method: conceptual translation. FEATURES Location/Qualifiers source 1..512 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..512 /product="putative serine/threonine protein kinase RCK1" /EC_number="2.7.11.1" /calculated_mol_wt="57850" Region 119..414 /region_name="STKc_RCK1-like" /note="Catalytic domain of RCK1-like Serine/Threonine Kinases; cd14096" /db_xref="CDD:270998" Site order(127..131,135,150,152,197,213..216,220,222,258..259, 261,263..264,266,300..301,304,317..321,323) /site_type="active" /db_xref="CDD:270998" Site order(127..130,135,150,152,197,213..216,220,263..264,266, 300..301) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270998" Site order(131,220,222,258..259,261,263,304,317..321,323) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270998" Site 300..321 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270998" CDS 1..512 /gene="RCK1" /locus_tag="YGL158W" /coded_by="NM_001181023.1:1..1539" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:15341652]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:39326682|PMID:15341652]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:10778743]" /note="Protein kinase involved in oxidative stress response; promotes pseudohyphal growth via activation of Ubp3p phosphorylation; identified as suppressor of S. pombe cell cycle checkpoint mutations; RCK1 has a paralog, RCK2, that arose from the whole genome duplication" /db_xref="GeneID:852719" /db_xref="SGD:S000003126" ORIGIN 1 msvnpefiad gidfypttpd aayfnaadgk nkvnringns enlhhsfasg crrsslsvdf 61 nvtssdseks eqsclennsq edeyfcdifs telkldetsn kstdysssnh qypeqlelhn 121 ykllnkigeg afsrvfkavg intddqapva ikaiikkgis sdailkgndr iqgssrkkvl 181 nevaihklvs knnphctkfi afqesanyyy lvtelvtgge ifdrivqltc fsedlarhvi 241 tqvaiaikhm hymgivhrdv kpenllfepi pfygldgdmq kedeftlgvg gggiglvklm 301 dfglakklrn ntaktpcgti eyvasevfts krysmkvdmw sigcvlftll cgyppfyekn 361 ektllkkisr gdyeflapww dnissgakna vthllevdpn krydiddfln dpwlnsydcl 421 kdsnsnsyas vqsilndsfd eraetlhcal scqsekqddt efsrsessey ifmteedrnl 481 rgswigepke cftldlatss iyrrrknkif fw // LOCUS NP_011358 347 aa linear PLN 30-JUN-2025 DEFINITION carbonyl reductase (NADPH-dependent) ARI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011358 VERSION NP_011358.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181022.3 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07955. On Jul 30, 2012 this sequence version replaced NP_011358.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..347 /product="carbonyl reductase (NADPH-dependent) ARI1" /calculated_mol_wt="37952" Region 6..323 /region_name="AR_SDR_e" /note="aldehyde reductase, extended (e) SDRs; cd05227" /db_xref="CDD:187538" Site order(11,13..16,36,62,85..89,129..131,169,173,200..203, 219..220) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:187538" Site order(89,91,131..133,136,169,200..202,223,235,242,313) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:187538" Site order(131,169,173) /site_type="active" /db_xref="CDD:187538" CDS 1..347 /gene="ARI1" /locus_tag="YGL157W" /coded_by="NM_001181022.3:1..1044" /experiment="EXISTENCE:direct assay:GO:0004090 carbonyl reductase (NADPH) activity [PMID:19016485|PMID:19577617]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016491 oxidoreductase activity [PMID:14574691]" /note="NADPH-dependent aldehyde reductase; utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily" /db_xref="GeneID:852720" /db_xref="SGD:S000003125" ORIGIN 1 mttdttvfvs gatgfialhi mndllkagyt vigsgrsqek ndgllkkfnn npklsmeive 61 diaapnafde vfkkhgkeik ivlhtaspfh fettnfekdl ltpavngtks ileaikkyaa 121 dtvekvivts staalvtptd mnkgdlvite eswnkdtwds cqanavaayc gskkfaekta 181 weflkenkss vkftlstinp gfvfgpqmfa dslkhgints sgivselihs kvggefynyc 241 gpfidvrdvs kahlvaiekp ectgqrlvls eglfccqeiv dilneefpql kgkiatgepa 301 tgpsflekns ckfdnsktkk llgfqfynlk dcivdtaaqm levqnea // LOCUS NP_011359 1083 aa linear PLN 30-JUN-2025 DEFINITION alpha-mannosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011359 VERSION NP_011359.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181021.1 REFERENCE 1 (residues 1 to 1083) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1083) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1083) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1083) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1083) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1083) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1083) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1083) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07956. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1083 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1083 /product="alpha-mannosidase" /EC_number="3.2.1.24" /calculated_mol_wt="124368" Region 289..1081 /region_name="MngB" /note="Alpha-mannosidase [Carbohydrate transport and metabolism]; COG0383" /db_xref="CDD:440152" CDS 1..1083 /gene="AMS1" /locus_tag="YGL156W" /coded_by="NM_001181021.1:1..3252" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:3281936]" /experiment="EXISTENCE:direct assay:GO:0004559 alpha-mannosidase activity [PMID:3281936]" /experiment="EXISTENCE:direct assay:GO:0034270 Cvt complex [PMID:20659891|PMID:12479808]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:26947009]" /experiment="EXISTENCE:mutant phenotype:GO:0009313 oligosaccharide catabolic process [PMID:12723970]" /experiment="EXISTENCE:mutant phenotype:GO:0019309 mannose catabolic process [PMID:26947009]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:26947009]" /note="Vacuolar alpha mannosidase; involved in free oligosaccharide (fOS) degradation; upregulated under glucose starvation; targeted to vacuole via CVT pathway and AP-3 pathway" /db_xref="GeneID:852721" /db_xref="SGD:S000003124" ORIGIN 1 mssediiydp qfkpvqgiye nrlrqfidtg gdyhdlnlpk fydkkrisld hdhvkvwwyq 61 vsfergsspv spdkrpswks iierdkkgel efreaninqp fgpswsttwf kvkislpedw 121 vksneqllfq wdcsnegivi dpktlipvta fsggerteyv lpktsdgkhf fyieagnngm 181 fgcgagstin ppddnrffhl rkadivwpdl daralyidfw mlgdaarelp gdswqkhqar 241 qlgnavmnlf dpndrssvrk crellqreyf dsflesskvy eqgesqvltn vygignchid 301 tawlwpfaet rrkivrswss qctlmdrfpe ykfvasqaqq fkwlledhpe ffnkvlipki 361 qqsqffavgg twvendtnip sgeslarqff fgqrfflkhf glkskifwlp dtfgyssqmp 421 qlcrlsgidk fltqklswnn insfphstfn wagidgsqll thmppgntyt adshfgdvlr 481 takqnktpey ygsglmlygk gdggggptee mlqkmrrirs mnnrngnvip klqvgitvde 541 fyddilkrtn qghdlptwsg elyfefhrgt ytsqaqtkkl mrlseiklhd lewiaaktsv 601 lypdsykyps kqinelwenv llcqfhdvlp gsciemvyky eavpmlhnvv kectslidkt 661 vqflqsqska dlvemrtltw skpekvseec slngsytssv tgyddyivla ngklkviick 721 ktgvitsitd etlgveyldt ehgrnklgan qfviyddkpl gwqawdtely svnqykyvtk 781 pkkvqvscnt kekcavevif qisekckiks vislnatavt daklskvdis ttvenwdarn 841 kflkvefpvn irndfasyet qfgitkrpth yntswdvakf evchhkfady seyskgvsil 901 ndckygfsth gnlmrlsllr spkapdahad mgtheikyai yphrgalssd tvklahefny 961 cfkyklpkdi gmnfddiisi sgdenvilsn ikrgeddsav ksnyslnprd eqsivvrvye 1021 slggesfasl nttlnlkrie kvdnlemkvy ksltatrdes nhainripik lrpfeiasfr 1081 lyf // LOCUS NP_011360 376 aa linear PLN 30-JUN-2025 DEFINITION protein geranylgeranyltransferase type I subunit CDC43 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011360 VERSION NP_011360.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181020.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07957. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..376 /product="protein geranylgeranyltransferase type I subunit CDC43" /EC_number="2.5.1.59" /calculated_mol_wt="42559" Region 13..352 /region_name="GGTase-I" /note="Geranylgeranyltransferase types I (GGTase-I)-like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-I s are a subgroup of the protein prenyltransferase family of lipid-modifying enzymes...; cd02895" /db_xref="CDD:239225" Site order(33,36..37,40,44,102,104..105,107..108,166,169..170, 216,218,222,286,288..289,292,331,340..341) /site_type="active" /note="active site cavity [active]" /db_xref="CDD:239225" Site order(36..37,40,104..105,166,286,331) /site_type="active" /note="peptide binding pocket [active]" /db_xref="CDD:239225" Site order(40,43,166,169,216,218,222,280,283,289,292,340) /site_type="lipid-binding" /note="lipid binding pocket [chemical binding]" /db_xref="CDD:239225" Site order(161,205,213..214,219,246,249,251..252,280..282) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:239225" Site order(286,288,341) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:239225" CDS 1..376 /gene="CDC43" /locus_tag="YGL155W" /gene_synonym="CAL1" /coded_by="NM_001181020.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0004662 CAAX-protein geranylgeranyltransferase activity [PMID:1400380]" /experiment="EXISTENCE:direct assay:GO:0005953 CAAX-protein geranylgeranyltransferase complex [PMID:1400380]" /experiment="EXISTENCE:direct assay:GO:0018344 protein geranylgeranylation [PMID:2034682]" /note="Beta subunit of geranylgeranyltransferase type I; subunit of the Ram2p-Cdc43p heterodimer that catalyzes the geranylgeranylation of the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis" /db_xref="GeneID:852722" /db_xref="SGD:S000003123" ORIGIN 1 mcqatngpsr vvtkkhrkff erhlqllpss hqghdvnrma iifysisgls ifdvnvsaky 61 gdhlgwmrkh yiktvlddte ntvisgfvgs lvmniphatt inlpntlfal lsmimlrdye 121 yfetildkrs larfvskcqr pdrgsfvscl dyktncgssv dsddlrfcyi availyicgc 181 rskedfdeyi dtekllgyim sqqcyngafg ahnephsgyt scalstlall ssleklsdkf 241 kedtitwllh rqvsshgcmk feselnasyd qsddggfqgr enkfadtcya fwclnslhll 301 tkdwkmlcqt elvtnylldr tqktltggfs kndeedadly hsclgsaala liegkfngel 361 cipqeifndf skrccf // LOCUS NP_011361 272 aa linear PLN 30-JUN-2025 DEFINITION holo-[acyl-carrier-protein] synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011361 VERSION NP_011361.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181019.1 REFERENCE 1 (residues 1 to 272) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 272) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 272) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 272) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07958. Method: conceptual translation. FEATURES Location/Qualifiers source 1..272 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..272 /product="holo-[acyl-carrier-protein] synthase" /EC_number="2.7.8.7" /calculated_mol_wt="30552" Region 32..197 /region_name="Sfp" /note="Phosphopantetheinyl transferase [Coenzyme transport and metabolism]; COG2091" /db_xref="CDD:441694" CDS 1..272 /gene="LYS5" /locus_tag="YGL154C" /coded_by="NM_001181019.1:1..819" /experiment="EXISTENCE:direct assay:GO:0008897 holo-[acyl-carrier-protein] synthase activity [PMID:10320345]" /experiment="EXISTENCE:mutant phenotype:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:3921525]" /note="Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine" /db_xref="GeneID:852723" /db_xref="SGD:S000003122" ORIGIN 1 mvkttevvse vskvagvrpw agifvveiqe diladeftfe almrtlplas qarilnkksf 61 hdrcsnlcsq llqlfgcsiv tglnfqelkf dkgsfgkpfl dnnrflpfsm tigeqyvamf 121 lvkcvstdey qdvgidiasp cnyggreele lfkevfsere fngllkasdp ctiftylwsl 181 kesytkftgt glntdlslid fgaisffpae gasmcitlde vplifhsqwf nneivticmp 241 ksisdkintn rpklynisls tlidyfiend gl // LOCUS NP_011362 341 aa linear PLN 30-JUN-2025 DEFINITION Pex14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011362 VERSION NP_011362.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181018.3 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07959. On Jul 30, 2012 this sequence version replaced NP_011362.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..341 /product="Pex14p" /calculated_mol_wt="38289" Region 8..53 /region_name="Pex14_N" /note="Pex14 N-terminal domain; pfam04695" /db_xref="CDD:461395" Region 144..>233 /region_name="DR0291" /note="Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only]; COG1579" /db_xref="CDD:441187" CDS 1..341 /gene="PEX14" /locus_tag="YGL153W" /coded_by="NM_001181018.3:1..1026" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:9094717|PMID:9312008]" /experiment="EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0016558 protein import into peroxisome matrix [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0016560 protein import into peroxisome matrix, docking [PMID:9094717]" /experiment="EXISTENCE:direct assay:GO:0016561 protein import into peroxisome matrix, translocation [PMID:20154681]" /experiment="EXISTENCE:direct assay:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078|PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0043335 protein unfolding [PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:0044721 protein import into peroxisome matrix, substrate release [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:1902495 transmembrane transporter complex [PMID:20154681]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:20154681|PMID:22375831|PMID:12667447]" /experiment="EXISTENCE:mutant phenotype:GO:0016560 protein import into peroxisome matrix, docking [PMID:16107331]" /experiment="EXISTENCE:physical interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:9094717|PMID:9312008|PMID:16107331]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:9312008|PMID:9094717]" /note="Central component of the peroxisomal importomer complex; peroxisomal protein import machinery docking complex component; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p" /db_xref="GeneID:852724" /db_xref="SGD:S000003121" ORIGIN 1 msdvvskdrk alfdsavsfl kdesikdapl lkkieflksk gltekeieia mkepkkdgiv 61 gdevskkigs tenrasqdmy lyeampptlp hrdwkdyfvm atatagllyg ayevtrryvi 121 pnilpeaksk legdkkeidd qfskidtvln aieaeqaefr kkesetlkel sdtiaelkqa 181 lvqttrsrek iedefrivkl evvnmqntid kfvsdndgmq elnniqkeme slkslmnnrm 241 esgnaqdnrl fsispngipg idtipsasei lakmgmqees dkekengsda nkddnavpaw 301 kkareqtids nasipewqkn taaneisvpd wqngqvedsi p // LOCUS NP_011364 1132 aa linear PLN 30-JUN-2025 DEFINITION Nut1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011364 VERSION NP_011364.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181016.1 REFERENCE 1 (residues 1 to 1132) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1132) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1132) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1132) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07960. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1132 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1132 /product="Nut1p" /calculated_mol_wt="128664" Region 1..1127 /region_name="Med5" /note="Mediator complex subunit Med5; pfam08689" /db_xref="CDD:370064" CDS 1..1132 /gene="NUT1" /locus_tag="YGL151W" /gene_synonym="MED5; SSX4" /coded_by="NM_001181016.1:1..3399" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9671481|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19368889]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:19368889]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9671481]" /note="Component of the RNA polymerase II mediator complex; mediator is required for transcriptional activation and also has a role in basal transcription" /db_xref="GeneID:852726" /db_xref="SGD:S000003119" ORIGIN 1 mekesvynla lkcaerqlts mefsnlykef fnekfpsliq eeeedtttta ninevkkasd 61 lvdtpsnnta atadtthlhe aldivcsdfv kilnlekpli ladyivevll vnynsdmikc 121 flpklnsvrn slllahffsk scsffaklsd tliidqvrkd lgnvivpnil sldmnsmnke 181 liaivskllq ttlklspspi lltsagckng sftllnqlsq tnkllfkrvs qtfeaklhfk 241 dtkpflnkds tnefvgspsl tspqyipspl sstkppgsvn saakykdmkl lryykniwln 301 nkiinweisn pdflskysai tssifqesfn svqnldqllt dlietsftcf aqfvsnkqyh 361 qansnltlle rkwvifitkh lpllilenss rsprvvtnal dnidekvvka iriyftekdd 421 nktnnedlfd dypstsldir hdfikgliml nlqpasvinn ylredqmidt silptrddlf 481 vrnlqgiqev vhntnsfiis sldtlelesi tesithdssn glfqvlhnfe svaptkqrei 541 vkaflsifed aikelnynri akicallffn fshslttils fsspaalmkt likfvdlsrn 601 grngsngnde sseyetinis lsfswailli inltqtygis vvdvalkype lsiknsfiin 661 fisnlpnvsd kyyleesnvn dsdmltkshn tvqswlcdlf vngsitdqli qnietrqlan 721 lipfivkqvl lsveigvltd issliggfey flqplllvgl iktfywleqf lscvkndtis 781 edilqgifnl lntlfnpvtl nedskafhta vlrlnaipll kvlrkfrvqs qsnygiyssd 841 aqgdpnlepl iaklvavlnv spvydvdpri insendysrk qlgygkflil nenpinkimt 901 nqinsfwslh sstyynldyl felielvtpk sflfdvlktl eyklatygvp gsenkrgsld 961 sehvfdyffy flvlydvkta eeasqlieym endakkskgd vdikgedlhe kndsaevrqe 1021 tqpkaeatqd ddfdmlfgen dtstqayeee eenedndgnn rtnnvpmika eetpsktnki 1081 silkrhsfav llherkllnd lalengeitk tenekfisyh dkylcmlktc vf // LOCUS NP_011365 1489 aa linear PLN 30-JUN-2025 DEFINITION chromatin-remodeling ATPase INO80 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011365 VERSION NP_011365.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181015.1 REFERENCE 1 (residues 1 to 1489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1489) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07961. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1489 /product="chromatin-remodeling ATPase INO80" /calculated_mol_wt="171325" Region 469..602 /region_name="DBINO" /note="DNA-binding domain; pfam13892" /db_xref="CDD:464024" Region 537..>1026 /region_name="PLN03142" /note="Probable chromatin-remodeling complex ATPase chain; Provisional" /db_xref="CDD:215601" Region 706..935 /region_name="DEXQc_INO80" /note="DEAQ-box helicase domain of INO80; cd18002" /db_xref="CDD:350760" Site order(733..739,773,841..842) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350760" Region 1295..1423 /region_name="SF2_C_SNF" /note="C-terminal helicase domain of the SNF family helicases; cd18793" /db_xref="CDD:350180" Site order(1324..1325,1333,1375,1396..1397) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:350180" Site order(1381..1382,1384,1407,1410) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350180" CDS 1..1489 /gene="INO80" /locus_tag="YGL150C" /coded_by="NM_001181015.1:1..4470" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:10952318]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:10952318]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:10952318]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:10952318]" /experiment="EXISTENCE:direct assay:GO:0019222 regulation of metabolic process [PMID:29462149]" /experiment="EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:10361278]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0000775 chromosome, centromeric region [PMID:23207916]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:10952318]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:23207916]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19620280]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:10952318]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:18258182]" /experiment="EXISTENCE:mutant phenotype:GO:0032006 regulation of TOR signaling [PMID:29462149]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:19620280]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17681272]" /note="Nucleosome spacing factor; subunit of INO80 chromatin remodeling complex; involved in positioning and spacing of nucleosomes over most genes independently of transcription; promotes nucleosome shifts in 3' direction; regulates yeast stress tolerance and cell metabolism through modulating nitrogen catabolite repression" /db_xref="GeneID:852728" /db_xref="SGD:S000003118" ORIGIN 1 mslavllnke dkdisdfskt tagksakkns rervadvapt rvldkkqayl sqlnsefnri 61 krrdsieqly qdwkfinlqe felisewnqq skdwqfdntn dsqdlhfkkl yrdmsminke 121 waeyqsfkna nlsdiinekd adedeedded eledgeedme edeastgrht ngksmrgngi 181 qksrkkdaaa aaaigkaikd dqthadtvvt vngdenedgn ngededndnd nennndndnd 241 nenendndsd nddeeengee deeeeeiedl deedfaafee qddnddedfn pdvekrrkrs 301 sssssstkls mnslslitsk kinknitins drpkivreli kmcnknkhqk ikkrrftnci 361 vtdynpidsk lnikitlkqy hvkrlkklin dakrereree alknnvgldg ndldndedgs 421 eshkrrklnn ntangaddan krkfntrhgl ptygmkmnak earaiqrhyd ntyttiwkdm 481 arkdstkmsr lvqqiqsirs tnfrktsslc areakkwqsk nfkqikdfqt rarrgirems 541 nfwkkneree rdlkkkieke ameqakkeee ekeskrqakk lnflltqtel yshfigrkik 601 tnelegnnvs sndsesqkni disalapnkn dfhaidfdne ndeqlrlraa enasnalaet 661 rakakqfddh anaheeeeee delnfqnpts lgeitieqpk ilactlkeyq lkglnwlanl 721 ydqgingila demglgktvq sisvlahlae nhniwgpflv vtpastlhnw vneiskflpq 781 fkilpywgna ndrkvlrkfw drknlrynkn apfhvmvtsy qmvvtdanyl qkmkwqymil 841 deaqaikssq ssrwknllsf hcrnrllltg tpiqnsmqel wallhfimps lfdshdefne 901 wfskdiesha eantklnqqq lrrlhmilkp fmlrrvkknv qselgdkiei dvlcdltqrq 961 aklyqvlksq istnydaien aatndstsns asnsgsdqnl inavmqfrkv cnhpdlfera 1021 dvdspfsftt fgkttsmlta svannnssvi snsnmnlssm ssnnisngkf tdliyssrnp 1081 ikyslprliy edlilpnynn dvdianklkn vkfnifnpst nyelclflsk ltgepslnef 1141 frvsttpllk rviertngpk ntdslsfkti tqellevtrn apsegvmasl lnvekhayer 1201 eylnciqrgy hpnvsappvt ievlgsshvt nsinnelfdp lisqalsdip aitqynmhvk 1261 kgipvedfpk tglfpeplnk nfssnismps mdrfitesak lrkldellvk lkseghrvli 1321 yfqmtkmmdl meeyltyrqy nhirldgssk ledrrdlvhd wqtnpeifvf llstragglg 1381 inltaadtvi fydsdwnpti dsqamdrahr lgqtrqvtvy rllvrgtiee rmrdrakqke 1441 qvqqvvmegk tqekniktie vgendsevtr egsksisqdg ikeaasala // LOCUS NP_001335775 101 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL149W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335775 VERSION NP_001335775.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348834.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80295. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..101 /product="uncharacterized protein" /calculated_mol_wt="11514" CDS 1..101 /locus_tag="YGL149W" /coded_by="NM_001348834.1:1..306" /note="hypothetical protein; conserved among S. cerevisiae strains; YGL149W is not an essential gene" /db_xref="GeneID:852727" /db_xref="SGD:S000003117" ORIGIN 1 msinallyvl slalliwtgs vvtlllllff clfllffslh ffcftrehvh ytlppkchsl 61 kfqfdsipss slslspfpfl ffprlravaf asptlsfffp i // LOCUS NP_011367 376 aa linear PLN 30-JUN-2025 DEFINITION bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011367 VERSION NP_011367.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181013.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07962. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..376 /product="bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2" /EC_number="4.2.3.5" /EC_number="1.5.1.38" /calculated_mol_wt="40707" Region 8..369 /region_name="aroC" /note="chorismate synthase; TIGR00033" /db_xref="CDD:272865" Site order(9..15,22,24,26,30..31,64..65,67..68,75..76,78,80,82, 109..113,123..124,132,208,213..218,229,231..233,237, 239..240,243..245,247..248,250,253..257,260..261,263..264, 268..269,291,294..296,298..300,307,309..312,315,353) /site_type="other" /note="Tetramer interface [polypeptide binding]" /db_xref="CDD:143612" Site order(17,46,103..104,124..127,130,250..251,310..311, 313..315,342,346) /site_type="active" /db_xref="CDD:143612" Site order(103..105,123,125,249..251,311,313..315,339,342,345) /site_type="other" /note="FMN-binding site [chemical binding]" /db_xref="CDD:143612" CDS 1..376 /gene="ARO2" /locus_tag="YGL148W" /coded_by="NM_001181013.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0004107 chorismate synthase activity [PMID:8971708]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:19793921]" /experiment="EXISTENCE:direct assay:GO:0042602 riboflavin reductase (NADPH) activity [PMID:8971708]" /experiment="EXISTENCE:mutant phenotype:GO:0004107 chorismate synthase activity [PMID:8971708]" /experiment="EXISTENCE:mutant phenotype:GO:0009073 aromatic amino acid family biosynthetic process [PMID:8971708]" /note="Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852729" /db_xref="SGD:S000003116" ORIGIN 1 mstfgklfrv ttygeshcks vgcivdgvpp gmslteadiq pqltrrrpgq sklstprdek 61 drveiqsgte fgktlgtpia mmiknedqrp hdysdmdkfp rpshadftys ekygikassg 121 ggrasareti grvasgaiae kflaqnsnve ivafvtqige ikmnrdsfdp efqhllntit 181 rekvdsmgpi rcpdasvagl mvkeiekyrg nkdsiggvvt cvvrnlptgl gepcfdklea 241 mlahamlsip askgfeigsg fqgvsvpgsk hndpfyfeke tnrlrtktnn sggvqggisn 301 geniyfsvpf ksvatisqeq ktatydgeeg ilaakgrhdp avtpraipiv eamtalvlad 361 alliqkardf srsvvh // LOCUS NP_011368 191 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL6 RPL9A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011368 VERSION NP_011368.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181012.3 REFERENCE 1 (residues 1 to 191) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 191) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 191) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 191) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07963. On Jul 30, 2012 this sequence version replaced NP_011368.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..191 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..191 /product="60S ribosomal protein uL6 RPL9A" /calculated_mol_wt="21438" Region 1..190 /region_name="PTZ00027" /note="60S ribosomal protein L6; Provisional" /db_xref="CDD:240234" CDS 1..191 /gene="RPL9A" /locus_tag="YGL147C" /coded_by="NM_001181012.3:1..576" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L9A; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9A has a paralog, RPL9B, that arose from a single-locus duplication" /db_xref="GeneID:852730" /db_xref="SGD:S000003115" ORIGIN 1 mkyiqteqqi evpegvtvsi ksrivkvvgp rgtltknlkh idvtftkvnn qlikvavhng 61 grkhvaalrt vkslvdnmit gvtkgykykm ryvyahfpin vnivekdgak fievrnflgd 121 kkirnvpvrd gvtiefstnv kdeivlsgns vedvsqnaad lqqicrvrnk dirkfldgiy 181 vshkgfited l // LOCUS NP_011369 311 aa linear PLN 30-JUN-2025 DEFINITION Rrt6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011369 VERSION NP_011369.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181011.1 REFERENCE 1 (residues 1 to 311) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 311) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 311) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 311) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07964. Method: conceptual translation. FEATURES Location/Qualifiers source 1..311 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..311 /product="Rrt6p" /calculated_mol_wt="34575" Region 144..300 /region_name="EMP24_GP25L" /note="emp24/gp25L/p24 family/GOLD; pfam01105" /db_xref="CDD:426051" CDS 1..311 /gene="RRT6" /locus_tag="YGL146C" /coded_by="NM_001181011.1:1..936" /note="Integral membrane protein, member of the p24 family; forms complex with Erp3p, Erp5p, and Emp24p; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription" /db_xref="GeneID:852731" /db_xref="SGD:S000003114" ORIGIN 1 mekaslniaq tkeipltdrr mglrgwkacs rphllgrill fmsilfitsa elssdvssre 61 vympifnnkl sfkvppikrs lllgaalyed feyssnnsas dgafctvfna gmndasrevv 121 feihvmdvlq eetdssrfgg tshergrqsl gfsvfnnkng dllrskknla sgtsvievnp 181 gncneflicf inlvydgsws sidteksvti kmtyndkldp dmllhlvnqm tpqvvkalnt 241 vsdglfqivs dttllqmesd rrdineatys ylivgfvslm vaqlisniiv ttyliikiks 301 npsshikkkg l // LOCUS NP_116577 701 aa linear PLN 30-JUN-2025 DEFINITION Tip20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116577 VERSION NP_116577.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181010.2 REFERENCE 1 (residues 1 to 701) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 701) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 701) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 701) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07965. Method: conceptual translation. FEATURES Location/Qualifiers source 1..701 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..701 /product="Tip20p" /calculated_mol_wt="81036" Region <9..151 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 239..695 /region_name="RINT1_TIP1" /note="RINT-1 / TIP-1 family; pfam04437" /db_xref="CDD:461309" CDS 1..701 /gene="TIP20" /locus_tag="YGL145W" /gene_synonym="TIP1" /coded_by="NM_001181010.2:1..2106" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11739780]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0070939 Dsl1/NZR complex [PMID:19151722]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9639310]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:30837368]" /experiment="EXISTENCE:physical interaction:GO:0070939 Dsl1/NZR complex [PMID:15958492]" /note="Peripheral membrane protein required for COPI vesicle fusion to the ER; mediates Sey1p-independent homotypic ER fusion; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p" /db_xref="GeneID:852732" /db_xref="SGD:S000003113" ORIGIN 1 mngiddllni ndrikqvqne rnelasklqn lkqslasndt evalseviaq diievgasve 61 gleqlrakyg dlqilnklek vavqqtqmqa gvdkldsfer qldelaeqpp dqftlddvka 121 lhskltsvfa tvpqinnids qyaaynklks kvtgkyndvi iqrlatnwsn tfdqklleaq 181 wdtqkfasts vglvkclren stklyqlsll ylpleeetqn gdserplsrs nnnqepvlwn 241 fkslannfnv rftyhfhats ssskietyfq flndylaenl ykcinifhdd cngltkpvih 301 eqfinyvlqp irdkvrstlf qndlktlivl isqilatdkn llnsfhyhgl glvslisdev 361 wekwinyeve manrqfinit knpedfpkss qnfvklinki ydylepfydl dfdllvrykl 421 mtcslifmnl tssyldyilt vdslnetrtk eqelyqtmak lqhvnfvyrk ikslssnfif 481 iqltdivnst eskkynslfq nvendyekam stdmqnsivh riqkllketl rnyfkistws 541 tlemsvdeni gpssvpsael vnsinvlrrl inkldsmdip laislkvkne llnvivnyft 601 esilklnkfn qnglnqflhd fkslssilsl pshatnykcm slhelvkilk lkydpnnqqf 661 lnpeyiktgn ftslkeaysi kylkdtkiqd alyriiygni l // LOCUS NP_011371 685 aa linear PLN 30-JUN-2025 DEFINITION putative lipase ROG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011371 VERSION NP_011371.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181009.1 REFERENCE 1 (residues 1 to 685) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 685) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 685) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 685) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07966. Method: conceptual translation. FEATURES Location/Qualifiers source 1..685 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..685 /product="putative lipase ROG1" /calculated_mol_wt="78011" Region 184..382 /region_name="DUF676" /note="Putative serine esterase (DUF676); pfam05057" /db_xref="CDD:309968" CDS 1..685 /gene="ROG1" /locus_tag="YGL144C" /coded_by="NM_001181009.1:1..2058" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25433290]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25433290]" /experiment="EXISTENCE:direct assay:GO:0047372 monoacylglycerol lipase activity [PMID:25433290]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:25433290]" /note="Lipase with specificity for monoacylglycerol; preferred substrate is 1-oleoylglycerol; null mutation affects lipid droplet morphology and overexpression causes increased accumulation of reactive oxygen species" /db_xref="GeneID:852733" /db_xref="SGD:S000003112" ORIGIN 1 msltptneil fhykssvkvg eleryvityh lydgeeippd lnlnslwlkv rnmnplsyra 61 aylmgpfmly cdvktaqyhh sqkivasvdy pkfepnvqtq qdfvaelsvh nirqkyvwia 121 dvmsqilftt ntnvtyevti gtskesvenp hdlpshlgsy spkltvnrlt tldlwnlpvq 181 ittpqkkkhl vvlthglhsn vstdlvyime qiykaqknyp heqivvkgyr gnvcqtekgv 241 kylgtrlaey iiqdlydesi rkisfvghsl ggliqafaia yiyevypwff kkvnpinfit 301 laspllgivt dnpayikvll sfgvigktgq dlglendvev gkpllyllsg lplieilrrf 361 krrtvyanai ndgivplyta sllfldyndi leqlqklken skksplinda stpvnqdffn 421 ktfispltkm lsilapqkfp tengseipkv sffesassil lpplperayi mdpdsrdpvi 481 ihdkiynedd ipqsefdied gffgkknill qaffagkker akyrnleeti arrwhegmaw 541 rkvvvalkpd ahnniivrrk fanaygwpvi dhlidvhfng dddddndend dinstqvvep 601 iqsvtegkkk yrkaenipqe ygwlnkvetn gvfdegptgm istvgeivea lakrgfsavi 661 drrnasedpn devlrfeemn sdlvq // LOCUS NP_011372 413 aa linear PLN 30-JUN-2025 DEFINITION Mrf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011372 VERSION NP_011372.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181008.3 REFERENCE 1 (residues 1 to 413) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 413) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 413) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 413) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07967. On Jul 30, 2012 this sequence version replaced NP_011372.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..413 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..413 /product="Mrf1p" /calculated_mol_wt="46639" Region 58..409 /region_name="PrfA" /note="Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; COG0216" /db_xref="CDD:439986" CDS 1..413 /gene="MRF1" /locus_tag="YGL143C" /coded_by="NM_001181008.3:1..1242" /experiment="EXISTENCE:direct assay:GO:0003747 translation release factor activity [PMID:10748224]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:8265342|PMID:14576278|PMID:11502169]" /experiment="EXISTENCE:genetic interaction:GO:0003747 translation release factor activity [PMID:1475194]" /experiment="EXISTENCE:genetic interaction:GO:0070126 mitochondrial translational termination [PMID:1475194]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:1475194]" /experiment="EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:1475194]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:14734569]" /experiment="EXISTENCE:mutant phenotype:GO:0070126 mitochondrial translational termination [PMID:15827612]" /note="Mitochondrial translation release factor RF1; involved in stop codon recognition and hydrolysis of peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability" /db_xref="GeneID:852734" /db_xref="SGD:S000003111" ORIGIN 1 mwlskfqfps rsifkgvflg hklpllvrlt stttnsksng siptqytels pllvkqaeky 61 eaelkdldkd lscgihfdvn kqkhyaklsa ltdtfieyke klnelkslqe mivsdpslra 121 eaeqeyaelv pqyettssrl vnkllpphpf adkpsllelr pgvggieami ftqnlldmyi 181 gyanyrkwky riisknenes gsgiidails ieeagsydrl rfeagvhrvq ripstetkgr 241 thtstaavvv lpqigdesak sidayertfk pgeirvdimr asgkggqhvn ttdsavrlth 301 ipsgivvsmq dersqhknka kaftilrarl aekerlekee kerkarksqv sstnrsdkir 361 tynfpqnrit dhrcgftlld lpgvlsgerl devieamsky dsterakell esn // LOCUS NP_011373 616 aa linear PLN 30-JUN-2025 DEFINITION putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011373 VERSION NP_011373.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181007.1 REFERENCE 1 (residues 1 to 616) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 616) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 616) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 616) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07968. Method: conceptual translation. FEATURES Location/Qualifiers source 1..616 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..616 /product="putative glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase" /calculated_mol_wt="72435" Region 16..484 /region_name="Glyco_transf_22" /note="Alg9-like mannosyltransferase family; pfam03901" /db_xref="CDD:281842" CDS 1..616 /gene="GPI10" /locus_tag="YGL142C" /coded_by="NM_001181007.1:1..1851" /experiment="EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:9576863|PMID:9639537]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:9759715]" /note="Integral membrane protein involved in GPI anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the glycosylphosphatidylinositol (GPI) core structure; human PIG-Bp is a functional homolog" /db_xref="GeneID:852735" /db_xref="SGD:S000003110" ORIGIN 1 mahevhrikp klgrtqifwv flafrvlnav ltrtffqade fwqalepahw kafkygeltw 61 ewkfgvrsyl fpmifeltyr lvslssillh yallllstig sdllilllpk yelswqvaed 121 lkrlpfdvtr sfeyygviya pkivmavlas igeyyivrfv qklylltldk rnekeeeerr 181 sglseitkfa lllsltnffn cffitrtfin sfemiltsia lyywdwtggq mikessftks 241 lifaflaclq rpssgliwvi psislilnlv gkkqyhllfi tfskvlrsff lvftanaiid 301 myfyekvtfp ffrflkfnft tplskfygva pwhfhffqsl pivlgasipa fafglffpls 361 krsfpkkyln pffqvkltil lnllvystlp hkefrfifpl qplfilissf gllrldrdyw 421 krlsglksll wlvpfvsvfi allldtfhes gsievmkflh eepeidslgf impchstpgq 481 sylhrsdiqd lwsitcnppl hllgdpeays kletymdesd hlyddisafi yknfpppfrk 541 dlrspgktys hewptylvvf ehmenaflkd flkdssyiey nrffnslahw dsrrsgdiii 601 yyklpfdysd ipaadi // LOCUS NP_011374 910 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-ubiquitin ligase HUL5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011374 VERSION NP_011374.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181006.1 REFERENCE 1 (residues 1 to 910) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 910) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 910) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 910) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07969. Method: conceptual translation. FEATURES Location/Qualifiers source 1..910 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..910 /product="ubiquitin-ubiquitin ligase HUL5" /EC_number="2.3.2.26" /calculated_mol_wt="105435" Region 35..910 /region_name="HUL4" /note="Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; COG5021" /db_xref="CDD:227354" CDS 1..910 /gene="HUL5" /locus_tag="YGL141W" /coded_by="NM_001181006.1:1..2733" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:17190603]" /experiment="EXISTENCE:direct assay:GO:0000502 proteasome complex [PMID:12408819]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0034450 ubiquitin-ubiquitin ligase activity [PMID:17190603]" /experiment="EXISTENCE:mutant phenotype:GO:0005829 cytosol [PMID:25344756]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25344756]" /experiment="EXISTENCE:mutant phenotype:GO:0010994 free ubiquitin chain polymerization [PMID:22497224]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:22497224]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:25344756]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:17190603]" /note="Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitination of a subset of cytosolic misfolded proteins upon heat shock" /db_xref="GeneID:852736" /db_xref="SGD:S000003109" ORIGIN 1 mlnftgqtrr rnvnlgnrtr nskkdlleka krererraqd klkedaskti qksirrhfsn 61 vrlfkntfts sqlvhmipay ggkliyyisq ydlqqllkls hnflssypns lgnrqllsll 121 klyqddalva etlsdlnmdc ptvdefldsl svylcrasfl syssasklad vieawevmhs 181 sasisifsis igsyekrpfa lqfycilaer nllpqlintn pilwdnmakt yshcskggqk 241 niakllipnf nnhiapsvlr sdndyvlkfy ekafidevia ttanyvsded hvknlmcyia 301 sspnqsckns vlitllsnkd fvrrlsweff htkfnaskte ahplfsvlaq lidmhllist 361 drelldynsv ipieelkkft stlkdftfrq ywelpksern pmlkeavpll skvyerdsrl 421 hflstennpt ywensekqfl nlrfyeelqe yedlyrehle eesdedmeke idldkerppl 481 kslllnkmkk rlksslrfrk leillelpff ipfeervdlf ymfialdkkr lsldddhnli 541 nmftpwastg mrkqsaiisr dnvledafna fnsigerfka sldvtfinef geeagidggg 601 itkeflttvs degfkdpkhe lfrtndryel ypsvvydatk lkyiwflgkv vgkclyehvl 661 idvsfadffl kkllnysngf lssfsdlgsy dsvlynnlik llnmttdeik sldltfeide 721 pessakvvdl ipngsktyvt kdnvllyvtk vtdyklnkrc fkpvsafhgg lsviiaphwm 781 emfnsielqm lisgerdnid lddlksntey ggykeedqti vdfwevlnef kfeeklnflk 841 fvtsvpqapl qgfkaldpkf girnagteky rlptastcvn llklpdyrnk tilrekllya 901 insgarfdls // LOCUS NP_011375 1219 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL140C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011375 VERSION NP_011375.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181005.1 REFERENCE 1 (residues 1 to 1219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1219) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07970. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1219 /product="uncharacterized protein" /calculated_mol_wt="137346" Region 9..438 /region_name="ArAE_2_N" /note="Putative ER transporter, 6TM, N-terminal; pfam10337" /db_xref="CDD:370988" Region 654..780 /region_name="FUSC_2" /note="Fusaric acid resistance protein-like; pfam13515" /db_xref="CDD:433273" CDS 1..1219 /locus_tag="YGL140C" /coded_by="NM_001181005.1:1..3660" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; non-essential gene; contains multiple predicted transmembrane domains" /db_xref="GeneID:852737" /db_xref="SGD:S000003108" ORIGIN 1 mslkskltki qklwlyyfpc drilakrick stvnttvafi fclipkitah lgaapamlpm 61 isvivhpgrr vggtihgaiy citglifgla yaifgrflaq rclgsswhel teaqqhvlhy 121 kryeaglail avfevimlff hgwmrsvshy yfgivfplfv vvhfafmdpl netagtiaka 181 ystpfylgia msifwnlvlf pewgttylgn ttidamnelh ksidysinff iavdphnssq 241 lysrdpvslg kllkmkslis skvnncrvvl heciyeftya yvsptklkpi istlenltvf 301 inglvntcql efillarhdn klrpddvaal tlpknkeisf anaekllkvi dklhpviysl 361 hrtmsecmyi aklvlahafd vkvsrvhscs mfkdgnfptf snnannlpnd vdiqnkindl 421 kqaleeckak fksemlsfdi dimspsdemf llssfllnfr qtadstlvim esvkdilvkr 481 qiqekkgwlr gkrlwflvlt nyetfsiwlk gdrnsvtend tlkgtfngnt ngfahdtvir 541 rpdyeenell sqkvssnkni vkddasldlp mtsepkgnss stsdtssspl tltktttfgt 601 nrtsrrqgrf sfmsmlisid kfcevshphf rfgfqvaial mlasfpmfip ktrqwyidyr 661 gtwigfvcil clepsvggtf wvfflravgv ifgaawgyls yvaavnqtnp yletvitvfg 721 aipgfyyllg tpyvkaaiie iisiyivmla ailpsqddil tsfakrclav gygggvaliv 781 qvfffplkar eqlneeisfv cgcisemell yatglegeqv assmseekyk kiekisksak 841 ealaratayk gltrqeprlk geytelenvf tqvifiqkqi ieridtisll rkqngsavie 901 efnsvvypyr rqmvgsiscl mralqeafin ktplpqflps ariahrrlin kvrqtlriry 961 pgqisnlsdk arkpnegdya dgkdeddddn eglvmkmnrr gqanttanph eyvlkekfls 1021 wnassaasee iieyieelln ltkilvgvne fkygflsrpl yedwaaeavt gfdnfingks 1081 npmntrrnrt pfdgtsiise gneslqstns nesqispdst rsyepecpva yekndnpaal 1141 nllriashka gqnadglpkt frnrafsits tsgqlsslsr hstlgnadpn ylndddessd 1201 ddlplalkmv lshmkekkd // LOCUS NP_011376 802 aa linear PLN 30-JUN-2025 DEFINITION putative flavin adenine dinucleotide transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_011376 VERSION NP_011376.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181004.3 REFERENCE 1 (residues 1 to 802) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 802) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 802) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 802) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07971. On Jul 30, 2012 this sequence version replaced NP_011376.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..802 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..802 /product="putative flavin adenine dinucleotide transporter" /calculated_mol_wt="90631" Region 32..167 /region_name="TRP_N" /note="ML-like domain; pfam14558" /db_xref="CDD:434037" Site order(37,50,53,55,64,66,68,80,82,84,96,107,114,134,136,138, 140,154,157,159,161) /site_type="other" /note="putative lipid binding cavity [chemical binding]" /db_xref="CDD:238454" Region 172..603 /region_name="TRP" /note="Transient receptor potential (TRP) ion channel; pfam06011" /db_xref="CDD:428720" CDS 1..802 /gene="FLC3" /locus_tag="YGL139W" /coded_by="NM_001181004.3:1..2409" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16717099]" /experiment="EXISTENCE:genetic interaction:GO:0030148 sphingolipid biosynthetic process [PMID:27462707]" /note="Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER; FLC3 has a paralog, FLC1, that arose from the whole genome duplication" /db_xref="GeneID:852738" /db_xref="SGD:S000003107" ORIGIN 1 mrflqvykss aligliilla skvnlaeakr klvatslvtc mensqlsans fdvvfnpddr 61 slhydldmst qidsyifadi dvyaygfkii tknvdlcsin wkqfcpvhpg niqidsieyi 121 sseyvneipg iayqvpdida yarvkitnnv seylaciqiy fsngktvsqi gvkwatavva 181 giglllsail stfgnstaas hisantmslf lyfqsvvvva mqhvhrvppi aaawaenlvw 241 smglirisfm qrifrwyvqs tggtpslylt stsmsvlaqr swqylmelpl ikratnvlyg 301 nantlifrgi krlgykmgie ntsivctgft ffvlcgyvla gfiivfkccv elatrlgwiq 361 karfwefrkq wrmilkgall ryiyigfvql tilsfwefte rdspavivia clfillscgl 421 mlwaawrtvf farrsvalyn npaallygde yvlhkygffy tmfnanhyww nivllsyifv 481 ksllvgfaqa sgqtqvlfmf ildlfyfvai iyykpyldrp tnimniliat vtvvnsflfm 541 ffsdlfnqsy kvaaimgwif fimnaafsfi llmmilafag mmlfsknpdl rfkpakddrt 601 sfqrntmkpe gtvnrsvane llalgnvakd hddnsdyesn dtgvndelkq aqdettpttv 661 tssddnkptf sekilskfsr pknenastda lrveapkqqt fphnltnlsr enlstlgskp 721 ypghtrsqsd ahnglinsfe eedtssntdp fhdstegdll dtsssdggfr sqnyvrddsi 781 nslgnnkqpl rkppgffdeg fm // LOCUS NP_011377 345 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL138C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011377 VERSION NP_011377.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181003.1 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07972. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..345 /product="uncharacterized protein" /calculated_mol_wt="40715" CDS 1..345 /locus_tag="YGL138C" /coded_by="NM_001181003.1:1..1038" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /note="hypothetical protein; has no significant sequence similarity to any known protein" /db_xref="GeneID:852739" /db_xref="SGD:S000003106" ORIGIN 1 mynfleffff fitytlfkst fvqgkssfpg hdvckfedqn fqtefflnvl kgdklqnlkq 61 eyeqykkqst lytgfviekq yeyqvaplqi nnflqvtfck ggkpiwnhil pfqkdldwae 121 plcipaqedd tisqnssvcf kfarvqkytq rnvtlyfpnk fvgfvfvcns skthpptqnn 181 fetipltpii sddirdykis wsikgritkv vpylhslsip mskyemlihs dknisneley 241 ksltsefwks yknlrkfknk emswineinp meqydssgne nvpnfhekld rtinriaqni 301 erphdalira iaahnrnsns gnitrrkylr rkiskmlknk iplkn // LOCUS NP_011378 889 aa linear PLN 30-JUN-2025 DEFINITION coatomer subunit beta' [Saccharomyces cerevisiae S288C]. ACCESSION NP_011378 VERSION NP_011378.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181002.1 REFERENCE 1 (residues 1 to 889) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 889) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 889) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 889) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07973. Method: conceptual translation. FEATURES Location/Qualifiers source 1..889 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..889 /product="coatomer subunit beta'" /calculated_mol_wt="99314" Region 6..293 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(12,30,34,40..41,53..54,72,76,82..83,95..96,113,118, 124..125,139,157,162,168..169,182..183,203,207,213..214, 226..227,244,249,255..256,268..269,289,292) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 19..53 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 59..95 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 100..137 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 144..180 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 187..225 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 231..267 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 305..792 /region_name="Coatomer_WDAD" /note="Coatomer WD associated region; cd22938" /db_xref="CDD:438571" Region 305..351 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438571" Region 316..351 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 357..391 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438571" Region 397..420 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438571" Region 439..468 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438571" Region 472..531 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438571" Region 535..574 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438571" Site order(568,598,719..721,748..749,770..771,774) /site_type="other" /note="coatomer beta'-subunit binding site [polypeptide binding]" /db_xref="CDD:438571" Region 575..599 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:438571" Site 775..777 /site_type="active" /note="coatomer subunit alpha binding site [active]" /db_xref="CDD:438571" CDS 1..889 /gene="SEC27" /locus_tag="YGL137W" /coded_by="NM_001181002.1:1..2670" /experiment="EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:21435344]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:7929113]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8001155]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:27068463]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17101773]" /experiment="EXISTENCE:physical interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17101773]" /note="Essential beta'-coat protein of the COPI coatomer; involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP" /db_xref="GeneID:852740" /db_xref="SGD:S000003105" ORIGIN 1 mkldikktfs nrsdrvkgid fhptepwvlt tlysgrvelw nyetqvevrs iqvtetpvra 61 gkfiarknwi ivgsddfrir vfnyntgekv vdfeahpdyi rsiavhptkp yvlsgsddlt 121 vklwnwennw aleqtfeghe hfvmcvafnp kdpstfasgc ldrtvkvwsl gqstpnftlt 181 tgqergvnyv dyyplpdkpy mitasddlti kiwdyqtksc vatleghmsn vsfavfhptl 241 piiisgsedg tlkiwnssty kvektlnvgl erswciathp tgrknyiasg fdngftvlsl 301 gndeptlsld pvgklvwsgg knaaasdift avirgneeve qdeplslqtk elgsvdvfpq 361 slahspngrf vtvvgdgeyv iytalawrnk afgkcqdfvw gpdsnsyali detgqikyyk 421 nfkevtswsv pmhsaidrlf sgallgvksd gfvyffdwdn gtlvrridvn akdviwsdng 481 elvmivntns ngdeasgytl lfnkdaylea anngniddse gvdeafdvly elsesitsgk 541 wvgdvfiftt atnrlnyfvg gktynlahyt kemyllgyla rdnkvyladr evhvygyeis 601 levlefqtlt lrgeieeaie nvlpnvegkd sltkiarfle gqeyyeealn ispdqdqkfe 661 lalkvgqltl ardlltdesa emkwralgda slqrfnfkla veaftnahdl eslfllhssf 721 nnkeglvtla kdaeragkfn lafnaywiag diqgakdlli ksqrfseaaf lgstyglgdd 781 avndivtkwk enlilngknt vservcgaeg lpgssssgda qplidldstp apeqadenke 841 aevedsefke snseaveaek keeeapqqqq seqqpeqgea vpepveees // LOCUS NP_011379 320 aa linear PLN 30-JUN-2025 DEFINITION 21S rRNA (uridine2791-2'-O) methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011379 VERSION NP_011379.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181001.1 REFERENCE 1 (residues 1 to 320) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 320) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 320) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 320) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07974. Method: conceptual translation. FEATURES Location/Qualifiers source 1..320 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..320 /product="21S rRNA (uridine2791-2'-O) methyltransferase" /EC_number="2.1.1.168" /calculated_mol_wt="37292" Region 25..308 /region_name="RlmE" /note="23S rRNA U2552 (ribose-2'-O)-methylase RlmE/FtsJ [Translation, ribosomal structure and biogenesis]; COG0293" /db_xref="CDD:440062" CDS 1..320 /gene="MRM2" /locus_tag="YGL136C" /coded_by="NM_001181001.1:1..963" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11867542]" /experiment="EXISTENCE:direct assay:GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity [PMID:11867542]" /experiment="EXISTENCE:direct assay:GO:0031167 rRNA methylation [PMID:11867542]" /experiment="EXISTENCE:mutant phenotype:GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity [PMID:11867542|PMID:14636587]" /experiment="EXISTENCE:mutant phenotype:GO:0031167 rRNA methylation [PMID:11867542|PMID:14636587]" /note="Mitochondrial 2' O-ribose methyltransferase; required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ" /db_xref="GeneID:852741" /db_xref="SGD:S000003104" ORIGIN 1 milvynrirs iissslgrih vrynsnsqnr wlnrqlkdpy tkeakvqnlr sraafklmqi 61 ddkyrlfskn rtdqrildlg yapgawsqva rqrsspnsmi lgvdilpcep phgvnsiqan 121 ilakrthdli rlffskhfql nrhddlhkdh gyfqnmleee lthvkdtely reiftsddiy 181 etpntnstli erekfpvdvi isdmyepwpq ttgfwnnitn qayfrmants gvsirdhyqs 241 idlcdaalvt aidllrplgs fvcklytgee enlfkkrmqa vftnvhkfkp dasrdesket 301 yyiglkkkrn vdkldvfsns // LOCUS NP_011380 217 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL1 RPL1B [Saccharomyces cerevisiae S288C]. ACCESSION NP_011380 VERSION NP_011380.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181000.3 REFERENCE 1 (residues 1 to 217) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 217) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 217) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 217) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07975. On Jul 30, 2012 this sequence version replaced NP_011380.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..217 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..217 /product="60S ribosomal protein uL1 RPL1B" /calculated_mol_wt="24355" Region 1..217 /region_name="Ribosomal_L1" /note="Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; cl00322" /db_xref="CDD:469720" Site order(26..28,31,33,35,37,162,164,166,210..211,213) /site_type="other" /note="mRNA/rRNA interface [nucleotide binding]" /db_xref="CDD:238235" CDS 1..217 /gene="RPL1B" /locus_tag="YGL135W" /gene_synonym="SSM2" /coded_by="NM_001181000.3:1..654" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:31439809]" /note="Ribosomal 60S subunit protein L1B; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1B has a paralog, RPL1A, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; ribosomes containing Rpl1b are more efficient in translation of respiration-related proteins" /db_xref="GeneID:852742" /db_xref="SGD:S000003103" ORIGIN 1 mskitssqvr ehvkellkys netkkrnfle tvelqvglkn ydpqrdkrfs gslklpncpr 61 pnmsicifgd afdvdraksc gvdamsvddl kklnknkkli kklskkynaf iasevlikqv 121 prllgpqlsk agkfptpvsh nddlygkvtd vrstikfqlk kvlclavavg nvemeedvlv 181 nqilmsvnff vsllkknwqn vgslvvkssm gpafrly // LOCUS NP_011381 433 aa linear PLN 30-JUN-2025 DEFINITION Pcl10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011381 VERSION NP_011381.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180999.1 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07976. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..433 /product="Pcl10p" /calculated_mol_wt="48454" Region 306..412 /region_name="CYCLIN_ScPCL7-like" /note="cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; cd20558" /db_xref="CDD:410261" Site order(324,326,372..378,380..382,396,399..400,403..404, 407..412) /site_type="other" /note="CDK interface [polypeptide binding]" /db_xref="CDD:410261" CDS 1..433 /gene="PCL10" /locus_tag="YGL134W" /coded_by="NM_001180999.1:1..1302" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:9584169]" /experiment="EXISTENCE:genetic interaction:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:9584169]" /experiment="EXISTENCE:mutant phenotype:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:9584169]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:9584169]" /note="Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate; PCL10 has a paralog, PCL8, that arose from the whole genome duplication" /db_xref="GeneID:852743" /db_xref="SGD:S000003102" ORIGIN 1 mdmtknhttd teefddgdir pvslgivddy nasfelplkp kflqsenfsd ltsewdqsrs 61 ntpglaegkt ekaqpcgttd ssknrihveq llesanemnn ylaqnienin nfqvgllngg 121 kglyssmgdd ssacingtnf sstsnfelsd deledttgct ssifdkdlfh qqnglsiprr 181 rsplfkspta sfeigdatdv eeqdiddsif secssitsfd mgglhislph deeedqektk 241 sesenpllhg ipvdvevphi svdealanfk etielllkls gnrkctgfnt rvekkeysnf 301 ymkskptlss adflkriqdk ceyqptvylv atflidtlfl trdgnnilql klnlqekevh 361 rmiiaavrls tklledfvhs heyfskvcgi skrlltklev sllicvcntk lmvsnrklaa 421 sklllnelrs fcv // LOCUS NP_011382 1264 aa linear PLN 30-JUN-2025 DEFINITION Itc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011382 VERSION NP_011382.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180998.1 REFERENCE 1 (residues 1 to 1264) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1264) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1264) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1264) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07977. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1264 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1264 /product="Itc1p" /calculated_mol_wt="145512" Region 24..124 /region_name="WAC_Acf1_DNA_bd" /note="ATP-utilizing chromatin assembly and remodelling N-terminal; pfam10537" /db_xref="CDD:463140" Region 423..483 /region_name="DDT" /note="domain in different transcription and chromosome remodeling factors; smart00571" /db_xref="CDD:214726" Region 869..952 /region_name="WSD" /note="Williams-Beuren syndrome DDT (WSD), D-TOX E motif; pfam15613" /db_xref="CDD:464775" CDS 1..1264 /gene="ITC1" /locus_tag="YGL133W" /coded_by="NM_001180998.1:1..3795" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12624196]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:14673157]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:12624196]" /experiment="EXISTENCE:physical interaction:GO:0008623 CHRAC [PMID:14673157]" /note="Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex; required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit of the mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex; ITC1 has a paralog, YPL216W, that arose from the whole genome duplication" /db_xref="GeneID:852744" /db_xref="SGD:S000003101" ORIGIN 1 mvlykrkpil lpdpkplpld lnvqvwhiee tgewfssyee flerfdfytr hhftceitgt 61 scltffqald seetqfkyve drfplklrep varflhfngi rrldalvekv yarfkndffp 121 gevvylrkqk dssttssnsq qstpqpddmv einsvgnpgl pqyqyqrryv ikekvqfnat 181 inpesreivm pahtkymlie eaassnksfi vdqgqiyrdr stftkhlikc ffkitlqras 241 skmgapwcvk peylamyglt mewpkdmlky kedepvvarr snsanvsspe seknkrqsks 301 sgksntsnda snkketkkkr kptevndsen nsseedkkkg qnvtsethsk krkkeaneep 361 ntenvesvpt panaepqavt itsimddlal pyqhppnifp nltyynekle cislgstkls 421 rpfdsfgkll qayqflntfg skiclshfsl dqfitslkct dpyelkgevv lvnirtqtsk 481 eqeiennglp mknkaettte edsenpsdwq rnsfirdmim krnsdkveyk ivhddpasdd 541 ildninhngs allievftal lrlfineegd wscivvenwi iddkgvlmer kdergegeak 601 qkrnahgyfl qdkekidnlk dtlkenatev qkesdaknet nsesdsksds dseerdpkle 661 kclnyrnvnw ierltkrqfn nsywliillg vledcrhlpm ytefidsfie kiipkdisat 721 qlpkqlwrnf crklsfsdkv nalwilvdlv shfspdikaa vddsmelcgq irserfkvar 781 elkteaavls nlqgdlqaiq eklnktdent psadgadkkd dsesnsepid liiiekkqkl 841 ieeqdkkvqa lqsdknfldn clfendlqrl kplgldrygn ryfwldhngv pfpqypagmn 901 etpksnnsls yhsgrlliqg pkassakffl nvsdeqlsnw qkirnsegis eatrevfgis 961 ktssgsynyv engievelld sndrvnplie ltpiqkkimd etpsrlllsp dqwycidkle 1021 dlsrimdwld nwgrkehdll rqirpimeri ksslslrdha lsltaftkne ekllkelenn 1081 eftenelnvd smdvddknsg vksevdvqvd aeekreavid ekleviadel mklddssktr 1141 nvlnriqele dqrdelleqk ksiinsqrpg arilarserk rtkisrgnkv nkqieiltdl 1201 vnyrhfkame dviawknvla nsiwgsslrk nasgnkrsgv ietvddklkd ivgqtsrtvt 1261 papn // LOCUS NP_011384 1403 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding E3 ubiquitin-protein ligase SNT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011384 VERSION NP_011384.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180996.1 REFERENCE 1 (residues 1 to 1403) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1403) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1403) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1403) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07978. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1403 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1403 /product="DNA-binding E3 ubiquitin-protein ligase SNT2" /EC_number="2.3.2.27" /calculated_mol_wt="163073" Region 112..256 /region_name="BAH_fungalPHD" /note="BAH, or Bromo Adjacent Homology domain, as present in fungal proteins containing PHD domains. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of...; cd04710" /db_xref="CDD:240061" Region 319..366 /region_name="PHD1_Snt2p_like" /note="PHD finger 1 found in Saccharomyces cerevisiae SANT domain-containing protein 2 (Snt2p) and similar proteins; cd15497" /db_xref="CDD:276972" Site order(319,331..335,339,361) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:276972" Region 559..602 /region_name="Myb_DNA-binding" /note="Myb-like DNA-binding domain; pfam00249" /db_xref="CDD:459731" Region 1040..1094 /region_name="PHD2_Snt2p_like" /note="PHD finger 2 found in Saccharomyces cerevisiae SANT domain-containing protein 2 (Snt2p) and similar proteins; cd15498" /db_xref="CDD:276973" Site order(1040,1054..1058,1062,1089) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:276973" Region 1108..1248 /region_name="ePHD_Snt2p_like" /note="Extended PHD finger found in Saccharomyces cerevisiae SANT domain-containing protein 2 (Snt2p) and similar proteins; cd15667" /db_xref="CDD:277137" Site order(1178,1188..1192,1196,1243) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:277137" CDS 1..1403 /gene="SNT2" /locus_tag="YGL131C" /coded_by="NM_001180996.1:1..4212" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:23878396]" /experiment="EXISTENCE:direct assay:GO:0034599 cellular response to oxidative stress [PMID:23878396]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:22570702]" /experiment="EXISTENCE:direct assay:GO:0070211 Snt2C complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:23878396]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:23878396]" /experiment="EXISTENCE:mutant phenotype:GO:0036205 histone catabolic process [PMID:22570702]" /note="Subunit of Snt2C complex, RING finger ubiquitin ligase (E3); physically associates with Ecm5p and Rpd3p; along with Ecm5p, recruits Rpd3p to small number of promoters; colocalizes with Ecm5p, independently of Rpd3p, to promoters of stress response genes upon oxidative stress; involved in ubiquitination, degradation of excess histones; interacts with Ubc4p; role in regulating genes encoding amine transporters; relocalizes from nucleus to cytoplasm upon DNA replication stress" /db_xref="GeneID:852746" /db_xref="SGD:S000003099" ORIGIN 1 mpkeedfqlp rrreaaknvn ynemeidtkl vqqiqiaeks gaktkgsnsq tprnckrtsn 61 pasrnekfky qkflhdkntc wnfiptlpps frknsrfsni ldlddamidl kkmslfntes 121 vllsandtiy misepagepy yvgrvvnfvs kpefsntihe aikttsvfpa kffqvrmnwf 181 yrprdiqehv ntfnprlvya slhqdicpis syrgkcsifh kdevfdvlpn ekeciirpni 241 fyfdelfdry tlkyykvyst dkilnkwnsk spflyvlnrr fryiytepky plenvlkkyv 301 fhelevnels padyqwdkrc qfckewciqk eslscdecgv cahlycmdpp ldrkpnkdvv 361 wtcfsclqkq qgtkdshvrf leeqaleldf irsvrqkiee isskaikenv gyntencwfq 421 ylgiysishi gdalndsmff pypfkpsrvg vkyqwngcnh nvpwrrnsyi sanseeergs 481 tktselawvl daskittrkl seyieqckse icpilnvrge tcnfidvvlk nllftnydta 541 eafkkckrel srkflkepsf taveirkfee avekfgselr pvceyvgtqp msmivrfyyn 601 wkktergltv rgklsklskn krkkeianhe ndvetkyidd ssfdteklsl aessfqcmfc 661 ktdyspmwyr vtggsddeki kirmqtgvne kteisekspa hskkneklga lcircarmwr 721 ryaikwvppl etlrkitgtc qnsfysaieg iieenntnkf tlspfqahnk llewelvqds 781 eliirqrmkv yknpnsfvkm krysmtfhtq lykmavrsyr knefhpetmq rdlelfiedn 841 kevrkaipeq kperakntkd efpvniirqs pgtiktsdts rnrkcndvfi ekasnnnipk 901 itnasndlie isiktggsss gsvsvdkgfk fvkfdnktfq rlrnslklvn nklpkyneps 961 tkkikmindi alsnplnepn gasynytvis hsketsvale kyhdgnkpsk mlekdmilkh 1021 tknkpknpdt awannsartf csvckekfnd ndnyevvcgn cgltvhyfcy aiklpkdmkk 1081 ntnlktfkwl cdpcsndlnp iisttyqcsm cptkdydydr yrsqsfkicp dalkctslgt 1141 wvhlvcslfn edikygngqs mqpalnttav likhsrftcg vcringgglv kcnkcqyryh 1201 itcaqnssnf klmfekknms vdttlpcikd vklndtytlr pilicdrhdi slegnelypl 1261 sykpqhtlsy ieqycryykc esdhslvelr yfeqlrlrhg empgnshdsa ikpkiyvlpf 1321 ertcphcgtn kslywyedii chscnlrsga qeldfdsasa nisndnglpv eitqqlmegi 1381 epamfdidis eagtdknthp ssq // LOCUS NP_011385 459 aa linear PLN 30-JUN-2025 DEFINITION mRNA guanylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011385 VERSION NP_011385.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180995.3 REFERENCE 1 (residues 1 to 459) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 459) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 459) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 459) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07979. On Jul 30, 2012 this sequence version replaced NP_011385.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..459 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..459 /product="mRNA guanylyltransferase" /EC_number="2.7.7.50" /calculated_mol_wt="52633" Region 1..449 /region_name="CEG1" /note="mRNA capping enzyme, guanylyltransferase (alpha) subunit [RNA processing and modification]; COG5226" /db_xref="CDD:227551" CDS 1..459 /gene="CEG1" /locus_tag="YGL130W" /coded_by="NM_001180995.3:1..1380" /experiment="EXISTENCE:genetic interaction:GO:0031533 mRNA capping enzyme complex [PMID:9710603]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15226422]" /experiment="EXISTENCE:mutant phenotype:GO:0004484 mRNA guanylyltransferase activity [PMID:8718687]" /experiment="EXISTENCE:mutant phenotype:GO:0006370 7-methylguanosine mRNA capping [PMID:8718687]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:27348091]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15226422]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:9832501]" /experiment="EXISTENCE:physical interaction:GO:0031533 mRNA capping enzyme complex [PMID:9710603]" /note="Guanylyltransferase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of two molecules of Ceg1p and a homodimer of Cet1p, the mRNA 5'-triphosphatase subunit; nuclear import of Ceg1p requires interaction with Cet1p; mammalian capping enzyme is a single bifunctional polypeptide; human homolog RNGTT can complement yeast ceg1 null mutant" /db_xref="GeneID:852747" /db_xref="SGD:S000003098" ORIGIN 1 mvlamesrva peipgliqpg nvtqdlkmmv ckllnspkpt ktfpgsqpvs fqhsdveekl 61 lahdyyvcek tdglrvlmfi vinpvtgeqg cfmidrenny ylvngfrfpr lpqkkkeell 121 etlqdgtlld gelviqtnpm tklqelrylm fdclaingrc ltqsptssrl ahlgkeffkp 181 yfdlraaypn rcttfpfkis mkhmdfsyql vkvaksldkl phlsdglift pvkapytagg 241 kdslllkwkp eqentvdfkl ildipmvedp slpkddrnrw yynydvkpvf slyvwqggad 301 vnsrlkhfdq pfdrkefeil ertyrkfael svsdeewqnl knleqplngr ivecaknqet 361 gawemlrfrd dklngnhtsv vqkvlesind svsledleei vgdikrcwde rranmaggsg 421 rplpsqsqna tlstskpvhs qppsndkepk yvdeddwsd // LOCUS NP_011386 450 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS29 RSM23 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011386 VERSION NP_011386.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180994.2 REFERENCE 1 (residues 1 to 450) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 450) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 450) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 450) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07980. On Apr 26, 2011 this sequence version replaced NP_011386.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..450 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..450 /product="mitochondrial 37S ribosomal protein mS29 RSM23" /calculated_mol_wt="50736" Region 124..444 /region_name="DAP3" /note="Mitochondrial ribosomal death-associated protein 3; pfam10236" /db_xref="CDD:431160" CDS 1..450 /gene="RSM23" /locus_tag="YGL129C" /gene_synonym="mS29" /coded_by="NM_001180994.2:1..1353" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit; has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p" /db_xref="GeneID:852748" /db_xref="SGD:S000003097" ORIGIN 1 mlrmstsrfi gqrlfttars lqaakpapkg ktqgfskkss svssyssakr vtpgslyknw 61 tntthtaqlq qtavplalpi fnfddisktl nkvvsysnkq ykslhhlgsf kksqfnelfq 121 kpvclvreda tnsflkklvs hpvkkfiitg epgvgktvll sqahayavds kqiiinisyp 181 elflngrndf sydddlklfi qpmylkklir kilkandpal lksielskdy kfsnanpkna 241 svkpfvtlnk tkntvldlls vmthphnrgk lmkaiidels vqskvpimft vdnfskvltt 301 aysayrnten kqiysldlqm gklmmdiisg etkfangess tilaisgvdr tnktlpvalg 361 kipvdpyvtr yhyepkfvel lqkgnvtefe vpklnkqevn elidyykqsn vlldkditgk 421 kwenlideky flsgngnpre llkslvlshr // LOCUS NP_011387 283 aa linear PLN 30-JUN-2025 DEFINITION U2-type spliceosomal complex subunit CWC23 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011387 VERSION NP_011387.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180993.1 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07981. On Oct 2, 2003 this sequence version replaced NP_011387.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..283 /product="U2-type spliceosomal complex subunit CWC23" /calculated_mol_wt="33106" Region 15..84 /region_name="DnaJ" /note="DnaJ domain; pfam00226" /db_xref="CDD:395170" Site order(50..52,61,64..65,68..69) /site_type="other" /note="HSP70 interaction site [polypeptide binding]" /db_xref="CDD:99751" CDS 1..283 /gene="CWC23" /locus_tag="YGL128C" /coded_by="NM_001180993.1:1..852" /experiment="EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]" /experiment="EXISTENCE:genetic interaction:GO:0000390 spliceosomal complex disassembly [PMID:19822657]" /note="Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p" /db_xref="GeneID:852749" /db_xref="SGD:S000003096" ORIGIN 1 mpgheledvi nqrlnlydvl elptpldvht iyddlpqikr kyrtlalkyh pdkhpdnpsi 61 ihkfhllsta tniltnadvr phydrwlief lrktndiern kliqkleese sstiptttph 121 pdllqiqrhg ellrklkhfn lpygdwkhln tqdqenasqh pyydcstlri vldnflqsnn 181 ksnclshlrn qvfitlsane iydiyfsern nyskddsiii ytvfdtpita qhvfrnwssg 241 nliptvkdis pliplhyysd fnletelndd iarlvsnepi lld // LOCUS NP_011388 127 aa linear PLN 30-JUN-2025 DEFINITION mediator complex subunit SOH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011388 VERSION NP_011388.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180992.1 REFERENCE 1 (residues 1 to 127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 127) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07982. Method: conceptual translation. FEATURES Location/Qualifiers source 1..127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..127 /product="mediator complex subunit SOH1" /calculated_mol_wt="14610" Region 2..127 /region_name="SOH1" /note="Rad5p-binding protein [General function prediction only]; COG5088" /db_xref="CDD:227420" CDS 1..127 /gene="SOH1" /locus_tag="YGL127C" /gene_synonym="MED31" /coded_by="NM_001180992.1:1..384" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:19057509]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19368889]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:15477388|PMID:15356001]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0006311 meiotic gene conversion [PMID:18069899]" /experiment="EXISTENCE:physical interaction:GO:0006281 DNA repair [PMID:8849885]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits" /db_xref="GeneID:852750" /db_xref="SGD:S000003095" ORIGIN 1 msstngnapa tpssdqnplp trfevelefi qslaniqyvt ylltqqqiwk spnfknylky 61 leywcnppys qcivypnclf ilkllngfme saivnedgll egldelpkii qlqgpqwmne 121 mverwan // LOCUS NP_011389 380 aa linear PLN 30-JUN-2025 DEFINITION Scs3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011389 VERSION NP_011389.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180991.3 REFERENCE 1 (residues 1 to 380) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 380) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 380) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 380) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07983. On Jul 30, 2012 this sequence version replaced NP_011389.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..380 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..380 /product="Scs3p" /calculated_mol_wt="42604" Region 38..370 /region_name="Scs3p" /note="Inositol phospholipid synthesis and fat-storage-inducing TM; pfam10261" /db_xref="CDD:402051" CDS 1..380 /gene="SCS3" /locus_tag="YGL126W" /gene_synonym="FIT2B" /coded_by="NM_001180991.3:1..1143" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:29526591|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:7706223]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:22927826]" /experiment="EXISTENCE:mutant phenotype:GO:0055091 phospholipid homeostasis [PMID:33033181]" /experiment="EXISTENCE:mutant phenotype:GO:0140042 lipid droplet formation [PMID:33033181]" /note="Protein required for normal ER membrane biosynthesis in response to ER stress; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; human homolog FIT2/FITM2, a fatty acyl-CoA diphosphatase, complements the yeast null mutant; disputed role in the synthesis of inositol phospholipids from inositol; required for inositol prototrophy" /db_xref="GeneID:852751" /db_xref="SGD:S000003094" ORIGIN 1 msskwfnaih llvcpltvlv gylmnaygyg aalqatlnkd glvnamlvkk gwfwtslvgw 61 wciiryravp gatgrdrrhi vqsfkryail tvwwyvftqg iwfgvgpimd lvfvytgghc 121 hydvfddagh vnedfqgsvt rtnralalih nvltlhghhq ehrqqqlwdr sigsiqgalq 181 atqpktpknv tasaaaaint fihdqmhrwq gplttsaqcr rfgghwaggh dpsghvflat 241 lmcmfllgel rvfgrralah lyaqkwqlvr lvtrlfdtgp lwtwrrcggg smtcgarlwr 301 aiveppvtca aallrltrci acdhpviill tllvtwlwql lltavasrfh tvrehmsgll 361 aayivtglvy ardaaalrpv // LOCUS NP_011390 600 aa linear PLN 30-JUN-2025 DEFINITION methylenetetrahydrofolate reductase (NAD(P)H) MET13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011390 VERSION NP_011390.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180990.1 REFERENCE 1 (residues 1 to 600) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 600) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 600) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 600) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07984. On Jan 21, 2003 this sequence version replaced NP_011390.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..600 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..600 /product="methylenetetrahydrofolate reductase (NAD(P)H) MET13" /EC_number="1.5.1.53" /calculated_mol_wt="68429" Region 19..586 /region_name="MTHFR" /note="Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; cl00246" /db_xref="CDD:444783" Site order(55,84,113..115,133..134,154,156,160,162,171,174, 177..178,187,189,282) /site_type="other" /note="FAD binding site [chemical binding]" /db_xref="CDD:238299" CDS 1..600 /gene="MET13" /locus_tag="YGL125W" /gene_synonym="MET11; MRPL45" /coded_by="NM_001180990.1:1..1803" /experiment="EXISTENCE:direct assay:GO:0004489 methylenetetrahydrofolate reductase [NAD(P)H] activity [PMID:10600168]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:10600168|PMID:10029993]" /note="Major isozyme of methylenetetrahydrofolate reductase; catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway" /db_xref="GeneID:852752" /db_xref="SGD:S000003093" ORIGIN 1 mkitekleqh rqtsgkptys feyfvpkttq gvqnlydrmd rmyeaslpqf iditwnaggg 61 rlshlstdlv ataqsvlgle tcmhltctnm pismiddale nayhsgcqni lalrgdpprd 121 aenwtpvegg fqyakdliky ikskygdhfa igvagypech pelpnkdvkl dleylkqkid 181 aggdfiitqm fydvdnfinw csqvraagmd vpiipgimpi ttyaaflrra qwgqisipqh 241 fssrldpikd ddelvrdigt nlivemcqkl ldsgyvshlh iytmnlekap lmilerlnil 301 ptesefnahp lavlpwrksl npkrkneevr pifwkrrpys yvartsqwav defpngrfgd 361 ssspafgdld lcgsdlirqs ankclelwst ptsindvafl vinylngnlk clpwsdipin 421 deinpikahl ielnqhsiit insqpqvngi rsndkihgwg pkdgyvyqkq ylefmlpktk 481 lpklidtlkn nefltyfaid sqgdllsnhp dnsksnavtw gifpgreilq ptivekisfl 541 awkeefyhil newklnmnky dkphsaqfiq sliddyclvn ivdndyispd dqihsillsl // LOCUS NP_011391 644 aa linear PLN 30-JUN-2025 DEFINITION guanine nucleotide exchange factor MON1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011391 VERSION NP_011391.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180989.2 REFERENCE 1 (residues 1 to 644) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 644) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 644) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 644) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07985. On Apr 26, 2011 this sequence version replaced NP_011391.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..644 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..644 /product="guanine nucleotide exchange factor MON1" /calculated_mol_wt="73347" Region 182..308 /region_name="Fuz_longin_1" /note="First Longin domain of FUZ, MON1 and HPS1; pfam19036" /db_xref="CDD:465953" Region 356..457 /region_name="Fuz_longin_2" /note="Second Longin domain of FUZ, MON1 and HPS1; pfam19037" /db_xref="CDD:465954" Region 487..633 /region_name="Fuz_longin_3" /note="Third Longin domain of FUZ, MON1 and HPS1; pfam19038" /db_xref="CDD:465955" CDS 1..644 /gene="MON1" /locus_tag="YGL124C" /gene_synonym="AUT12" /coded_by="NM_001180989.2:1..1935" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12364329]" /experiment="EXISTENCE:direct assay:GO:0001786 phosphatidylserine binding [PMID:24413168]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:20797862|PMID:24413168]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:20797862]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12387888]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:24413168]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:24413168]" /experiment="EXISTENCE:direct assay:GO:0035658 Mon1-Ccz1 complex [PMID:24413168]" /experiment="EXISTENCE:genetic interaction:GO:0044395 protein targeting to vacuolar membrane [PMID:23979137]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:12387888]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0044395 protein targeting to vacuolar membrane [PMID:23979137]" /experiment="EXISTENCE:mutant phenotype:GO:0048278 vesicle docking [PMID:14662743]" /experiment="EXISTENCE:physical interaction:GO:0035658 Mon1-Ccz1 complex [PMID:20797862]" /note="Subunit of heterodimeric guanine nucleotide exchange factor (GEF); subunit of Mon1-Ccz1 GEF complex which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; role in localizing Ypt7p to vacuolar membrane; required for autophagy, CVT pathway, and mitophagy; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:852753" /db_xref="SGD:S000003092" ORIGIN 1 mnlnesylda eipkgqlkhs ksgnfegipi vattseptts vnldetffkk apiampicdd 61 hsvskstsvn slnttslasr rsplqtkklq aknnllsadl aksnddttra lnspkkdfgp 121 yldsendirs rlaesiysme tsirgselqr rpyvsneipn vfkfskfnsn cklnesqtlc 181 dknffiftsa gkpiycmhgk deqimsytgl vntvisyfqv ngpselktis tltsgkrltf 241 ldkspillma qsergessne llnqldflys yilsslserq llrlfskren fdlrnylest 301 dfenldeics licnrmfpdl llnslqclpf nhssrlklqn vvlqqlekrq diprgtllyg 361 liiapqnklc cvlrprghtl httdlhllfc lishqfqnld etqelwvpic fpkfnssgfl 421 ycyikflpnd thsneksalv lisaqkdaff slksfsdeli ikleeekllk kintskgfkl 481 sdipapmvhh fiykskqnvq yvmphfevns nialdssqgl eyelklktyy qqlhgtvvrd 541 ngnllsrsml nfvrwsskdn edlamdetqm dfseldeyii gnssfkqesv nmvgmawvtp 601 tfelylignn givdkrvlfk sarkvanwcq khesrlfisd gavf // LOCUS NP_011392 254 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS5 RPS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011392 VERSION NP_011392.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180988.1 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07986. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..254 /product="40S ribosomal protein uS5 RPS2" /calculated_mol_wt="27319" Region 31..252 /region_name="PTZ00070" /note="40S ribosomal protein S2; Provisional" /db_xref="CDD:240255" CDS 1..254 /gene="RPS2" /locus_tag="YGL123W" /gene_synonym="RPS4; SUP138; SUP38; SUP44" /coded_by="NM_001180988.1:1..765" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2517480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:385049|PMID:2517480|PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:2517480]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0045903 positive regulation of translational fidelity [PMID:17545469|PMID:3522920]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:31182640]" /note="Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; N-terminal mitochondrial avoidance segment (MAS) required for targeting to nucleus; methylated on one or more arginine residues by Hmt1p; required for release of methyltransferase Bud23p from pre-40S precursor; homologous to mammalian ribosomal protein S2 and bacterial S5" /db_xref="GeneID:852754" /db_xref="SGD:S000003091" ORIGIN 1 msapeaqqqk rggfggrnrg rpnrrgprnt eekgwvpvtk lgrlvkagki ttieeiflhs 61 lpvkefqiid tllpglqdev mnikpvqkqt ragqrtrfka vvvvgdsngh vglgiktake 121 vagairagii iaklsvipir rgywgtnlgq phslatkttg kcgsvtvrli paprgsgiva 181 spavkkllql agvedvytqs ngktrtlent lkaafvaign tygfltpnlw aeqplpvspl 241 diysdeasaq kkrf // LOCUS NP_011393 525 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding protein NAB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011393 VERSION NP_011393.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180987.3 REFERENCE 1 (residues 1 to 525) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 525) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 525) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 525) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07987. On Jul 30, 2012 this sequence version replaced NP_011393.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..525 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..525 /product="mRNA-binding protein NAB2" /calculated_mol_wt="58190" Region 1..101 /region_name="Nab2" /note="Nuclear abundant poly(A) RNA-bind protein 2 (Nab2); pfam11517" /db_xref="CDD:402904" Region 252..278 /region_name="Nab2p_Zf1" /note="Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1; pfam18260" /db_xref="CDD:436370" CDS 1..525 /gene="NAB2" /locus_tag="YGL122C" /coded_by="NM_001180987.3:1..1578" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:26220998]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7962083|PMID:8474438|PMID:11779864]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7962083]" /experiment="EXISTENCE:direct assay:GO:0008097 5S rRNA binding [PMID:26220998]" /experiment="EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:17630287]" /experiment="EXISTENCE:direct assay:GO:0008312 7S RNA binding [PMID:26220998]" /experiment="EXISTENCE:direct assay:GO:0033204 ribonuclease P RNA binding [PMID:26220998]" /experiment="EXISTENCE:direct assay:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:26220998]" /experiment="EXISTENCE:genetic interaction:GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:26119729]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:11779864]" /experiment="EXISTENCE:mutant phenotype:GO:0043488 regulation of mRNA stability [PMID:17636033]" /experiment="EXISTENCE:physical interaction:GO:0043488 regulation of mRNA stability [PMID:17636033]" /note="Nuclear Poly(A+) RNA-binding guard protein; required for nuclear mRNA export and poly(A) tail length control; stimulates RNA polymerase III transcription by enhancing TFIIIB binding to promoters; dimerizes upon RNA binding; protects mRNA against decay by nuclear exosome in a poly(A)-tail-dependent manner; involved in forming export-competent mRNPs in the nucleus; autoregulates mRNA levels; NLS binds Kap104p; protein abundance increases under DNA replication stress; related to human hnRNPs" /db_xref="GeneID:852755" /db_xref="SGD:S000003090" ORIGIN 1 msqeqytenl kvivaeklag ipnfnediky vaeyivlliv nggtvesvvd elaslfdsvs 61 rdtlanvvqt affalealqq gesaenivsk irmmnaqslg qsdiaqqqqq qqqqqqpdia 121 qqqpqqqpqq qpqqqpqqqp qqqpqqqpqq qpqqqpqlqp lqpqlgtqna mqtdapatps 181 pisafsgvvn aaappqfapv dnsqrftqrg ggavgknrrg grggnrggrn nnstrfnpla 241 kalgmagesn mnftptkkeg rcrlfphcpl grscphahpt kvcneypncp kppgtceflh 301 pnedeelmke mertreefqk rkadllaakr kpvqtgivlc kfgalcsnps cpfghptpan 361 edakvidlmw cdknltcdnp ecrkahssls kikevkpisq kkaapppvek sleqckfgth 421 ctnkrckyrh arshimcreg anctridclf ghpinedcrf gvnckniycl frhppgrvlp 481 ekkgaapnsn vptnerpfal penaiienap pqtsfthqeq dtemn // LOCUS NP_011394 126 aa linear PLN 30-JUN-2025 DEFINITION Gpg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011394 VERSION NP_011394.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180986.1 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07988. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..126 /product="Gpg1p" /calculated_mol_wt="14791" CDS 1..126 /gene="GPG1" /locus_tag="YGL121C" /coded_by="NM_001180986.1:1..381" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:1905907 negative regulation of amyloid fibril formation [PMID:19129493]" /note="Proposed gamma subunit of the heterotrimeric G protein; interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing" /db_xref="GeneID:852756" /db_xref="SGD:S000003089" ORIGIN 1 mfylsdieee asagaeptyn fwevllfsnt qenlvtvvge lhtltdrvvh ykiepesrev 61 tattlpslla lllekrnqar rlyrdvlsmk mseldwdidd lftqlqeelt rtddtlsmyp 121 rrrfyh // LOCUS NP_011395 767 aa linear PLN 30-JUN-2025 DEFINITION DEAH-box ATP-dependent RNA helicase PRP43 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011395 VERSION NP_011395.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180985.1 REFERENCE 1 (residues 1 to 767) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 767) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 767) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 767) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07989. Method: conceptual translation. FEATURES Location/Qualifiers source 1..767 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..767 /product="DEAH-box ATP-dependent RNA helicase PRP43" /EC_number="3.6.4.13" /calculated_mol_wt="87431" Region <12..>124 /region_name="FlhF" /note="flagellar biosynthetic protein FlhF; TIGR03499" /db_xref="CDD:274609" Region 92..>724 /region_name="HrpA" /note="HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; COG1643" /db_xref="CDD:441249" CDS 1..767 /gene="PRP43" /locus_tag="YGL120C" /coded_by="NM_001180985.1:1..2304" /experiment="EXISTENCE:direct assay:GO:0000390 spliceosomal complex disassembly [PMID:16357217]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:17875666]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:genetic interaction:GO:0000390 spliceosomal complex disassembly [PMID:17875666]" /experiment="EXISTENCE:genetic interaction:GO:0030490 maturation of SSU-rRNA [PMID:19801658]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16382143]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16382143]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16382143]" /experiment="EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:11886864]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:16382144|PMID:16227579]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:16382143]" /experiment="EXISTENCE:mutant phenotype:GO:0071014 post-mRNA release spliceosomal complex [PMID:11886864]" /note="RNA helicase in the DEAH-box family; functions in both RNA polymerase I and polymerase II transcript metabolism; catalyzes removal of U2, U5, and U6 snRNPs from the postsplicing lariat-intron ribonucleoprotein complex; required for efficient biogenesis of both small- and large-subunit rRNAs; acts with Sqs1p to promote 20S to 18S rRNA processing catalyzed by endonuclease Nob1p" /db_xref="GeneID:852757" /db_xref="SGD:S000003088" ORIGIN 1 mgskrrfsse hpdpvetsip eqaaeiaeel skqhplpsee plvhhdagef kglqrhhtsa 61 eeaqkledgk inpftgreft pkyvdilkir relpvhaqrd eflklyqnnq imvfvgetgs 121 gkttqipqfv lfdemphlen tqvactqprr vaamsvaqrv aeemdvklge evgysirfen 181 ktsnktilky mtdgmllrea medhdlsrys ciildeaher tlatdilmgl lkqvvkrrpd 241 lkiiimsatl daekfqryfn dapllavpgr typvelyytp efqrdyldsa irtvlqihat 301 eeagdillfl tgedeiedav rkislegdql vreegcgpls vyplygslpp hqqqrifepa 361 peshngrpgr kvvistniae tsltidgivy vvdpgfskqk vynprirves llvspiskas 421 aqqragragr trpgkcfrly teeafqkeli eqsypeilrs nlsstvlelk klgiddlvhf 481 dfmdppapet mmraleelny laclddegnl tplgrlasqf pldpmlavml igsfefqcsq 541 eiltivamls vpnvfirptk dkkraddakn ifahpdgdhi tllnvyhafk sdeayeygih 601 kwcrdhylny rslsaadnir sqlerlmnry nlelnttdye spkyfdnirk alasgffmqv 661 akkrsgakgy itvkdnqdvl ihpstvlghd aewviynefv ltsknyirtv tsvrpewlie 721 iapayydlsn fqkgdvklsl erikekvdrl nelkqgknkk kskhskk // LOCUS NP_011396 501 aa linear PLN 30-JUN-2025 DEFINITION protein kinase COQ8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011396 VERSION NP_011396.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180984.1 REFERENCE 1 (residues 1 to 501) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 501) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 501) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 501) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07990. Method: conceptual translation. FEATURES Location/Qualifiers source 1..501 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..501 /product="protein kinase COQ8" /calculated_mol_wt="56611" Region 153..403 /region_name="ABC1_ADCK3" /note="Activator of bc1 complex (ABC1) kinases, also called aarF domain containing kinase 3; cd13970" /db_xref="CDD:270872" Site order(207..211,213,223,225,284,303..306,346,350..351,353, 364..365) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:270872" CDS 1..501 /gene="COQ8" /locus_tag="YGL119W" /gene_synonym="ABC1" /coded_by="NM_001180984.1:1..1506" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:11279158|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:18801050]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:27499294]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:27499294]" /experiment="EXISTENCE:mutant phenotype:GO:0004672 protein kinase activity [PMID:22593570]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:11279158|PMID:25498144]" /experiment="EXISTENCE:mutant phenotype:GO:0008289 lipid binding [PMID:27499294]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:27499294]" /note="ATPase required for ubiquinone biosynthesis and respiratory growth; maintains levels of CoQ biosynthetic proteins; binds to CoQ biosynthesis intermediates; UbiB protein kinase-like family member that lacks canonical protein kinase activity; similar to prokaryotic proteins involved in ubiquinone biosynthesis; human homolog ADCK3 complements a coq8 null, is associated with CoQ and respiratory-chain deficiencies, and is mutated in autosomal-recessive cerebellar ataxia type 2" /db_xref="GeneID:852758" /db_xref="SGD:S000003087" ORIGIN 1 mvtnmvklrn lrrlycssrl lrtiqngris svssislskk yttksakege enverkheee 61 kkdtlksssv ptsrisrlfh ygslaagvgm naaakgisev akgnsptwks lilsdsnidr 121 itnkfskmrg valkigqlls fqdekvlpke lyeilsrvqn sanhmpqrql ekvmakelga 181 nwktkfskfd kipmaaasig qvhaaelpsg qrvvvkiqyp gvkesidsdl nsllmlltas 241 sllpkglfld ktianartel kwecdynrea ralqkfeall kddpafevph vfpeyttdni 301 itmtrmegte imklpkasqe tknfisenim rlcleeiatf kymqtdpnwa nflyngrtkk 361 ielldfgasr pfaedfilky rklltyatlr drkgayemsv qlgyltgles qsmkdahvds 421 vltlgepfrg dvdksfdfkd qtvsdrirgn iglmlnerlc pppeetyslh rkfsgifllc 481 armgasvhca klfkeifayk v // LOCUS NP_001335776 145 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL118C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335776 VERSION NP_001335776.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348835.1 REFERENCE 1 (residues 1 to 145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 145) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80296. Method: conceptual translation. FEATURES Location/Qualifiers source 1..145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..145 /product="uncharacterized protein" /calculated_mol_wt="16790" CDS 1..145 /locus_tag="YGL118C" /coded_by="NM_001348835.1:1..438" /note="hypothetical protein; conserved among S. cerevisiae strains; YGL118C is not an essential gene" /db_xref="GeneID:852760" /db_xref="SGD:S000003086" ORIGIN 1 mppepvwhis avtekfpthg ailyisltfs fykkmlrvlw hillvygkha gkrkyrkvmt 61 etndslymkr nncsgeyatl alstrscsfn mqqndwvtme glfpfvmvlc hletkpmkig 121 iqlilqvpfm glgihkenke fylil // LOCUS NP_011398 265 aa linear PLN 30-JUN-2025 DEFINITION Aro5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011398 VERSION NP_011398.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180982.3 REFERENCE 1 (residues 1 to 265) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 265) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 265) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 265) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07991. On Jul 30, 2012 this sequence version replaced NP_011398.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..265 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..265 /product="Aro5p" /calculated_mol_wt="30624" CDS 1..265 /gene="ARO5" /locus_tag="YGL117W" /coded_by="NM_001180982.3:1..798" /note="Protein involved in aromatic amino acid biosynthesis; up-regulated following GCN4 induction, amino acid starvation, rapamycin treatment in GCN4-dependent manner; promoter contains Gcn4 control response element, which is bound by Gcn4p in vivo" /db_xref="GeneID:852761" /db_xref="SGD:S000003085" ORIGIN 1 mqpisikdve sdqgkvyivn alkdlvckcl lefvdiqies fmypddpkcf trifkgnkiv 61 neasdkdskv rsypsslgvg hsalfpliyi rqktnslrfl ndpkqlptpl vddmnakfkg 121 iikvyenlih lyhsyqtvdc nnmnqqkllg dlvsrgnfml dilhgyvtia stivrdskda 181 nilidtvnrf ihdtilfhkr iihnsnayte yhvmkrgmqr nqseetlvel efrildvsdv 241 nldnefddfl qhrktslkit hrrvi // LOCUS NP_011399 610 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein transferase activating protein CDC20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011399 VERSION NP_011399.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180981.1 REFERENCE 1 (residues 1 to 610) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 610) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 610) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 610) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07992. Method: conceptual translation. FEATURES Location/Qualifiers source 1..610 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..610 /product="ubiquitin-protein transferase activating protein CDC20" /calculated_mol_wt="67229" Region 265..301 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <280..554 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 304..340 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 348..381 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 388..422 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 430..476 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 528..562 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..610 /gene="CDC20" /locus_tag="YGL116W" /gene_synonym="PAC5" /coded_by="NM_001180981.1:1..1833" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0010997 anaphase-promoting complex binding [PMID:15916961]" /experiment="EXISTENCE:direct assay:GO:0033597 mitotic checkpoint complex [PMID:11726501]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0051321 meiotic cell cycle [PMID:17889668]" /experiment="EXISTENCE:direct assay:GO:1990757 ubiquitin ligase activator activity [PMID:15060174|PMID:19362536]" /experiment="EXISTENCE:genetic interaction:GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process [PMID:9334304]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:12152084]" /experiment="EXISTENCE:mutant phenotype:GO:0031398 positive regulation of protein ubiquitination [PMID:9504909]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:10855492]" /experiment="EXISTENCE:mutant phenotype:GO:0045842 positive regulation of mitotic metaphase/anaphase transition [PMID:10647015]" /experiment="EXISTENCE:mutant phenotype:GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process [PMID:9334304]" /experiment="EXISTENCE:physical interaction:GO:0005680 anaphase-promoting complex [PMID:9501986]" /experiment="EXISTENCE:physical interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:9461437]" /experiment="EXISTENCE:physical interaction:GO:0033597 mitotic checkpoint complex [PMID:11726501|PMID:10704439]" /note="Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:852762" /db_xref="SGD:S000003084" ORIGIN 1 mpessrdkgn aaisgnrsvl siasptklni lssdwsrnqg kvsknslkrs sslnirnskr 61 pslqasansi ysrpkitiga pplirrdssf fkdefdakkd katfsayssr syptigsesv 121 vsqtslsqpt tsrevdeqft vaadryipil qgasqnkvdp etlhealppp naspishlra 181 qtkivfkqnv aeacgldmnk rilqympepp kcsslrqksy imkkrthysy qqeqkipdli 241 klrkintnpe rildapgfqd dfylnllsws kknvlaiald talylwnatt gdvslltdfe 301 ntticsvtws dddchisigk edgnteiwdv etmslirtmr sglgvrigsl swldtliatg 361 srsgeiqind vrikqhivst waehtgevcg lsyksdglql asggndntvm iwdtrtslpq 421 fskkthtaav kalswcpysp nilasgggqt dkhihfwnsi tgarvgsint gsqvsslhwg 481 qshtstnggm mnkeivatgg npenaisvyn yetkfkvaev vhahearicc sqlspdgttl 541 atvggdenlk fykifdprct grsredglmd gmlgligkeg crtndkenrs knsseihtrr 601 psstsqylir // LOCUS NP_011400 322 aa linear PLN 30-JUN-2025 DEFINITION AMP-activated serine/threonine-protein kinase regulatory subunit SNF4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011400 VERSION NP_011400.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180980.1 REFERENCE 1 (residues 1 to 322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 322) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07993. Method: conceptual translation. FEATURES Location/Qualifiers source 1..322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..322 /product="AMP-activated serine/threonine-protein kinase regulatory subunit SNF4" /calculated_mol_wt="36270" Region 30..172 /region_name="CBS_euAMPK_gamma-like_repeat1" /note="Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1; cd04618" /db_xref="CDD:341388" Site order(38,40..42,64..66,146,164,166,168..169,172) /site_type="other" /note="ligand binding site II [chemical binding]" /db_xref="CDD:341388" Region 38..110 /region_name="CBS repeat" /note="CBS repeat [structural motif]" /db_xref="CDD:341388" Site order(64,78,82..83,86,124,146..148,168) /site_type="other" /note="ligand binding site I [chemical binding]" /db_xref="CDD:341388" Region 124..172 /region_name="CBS repeat" /note="CBS repeat [structural motif]" /db_xref="CDD:341388" Region 195..318 /region_name="CBS_euAMPK_gamma-like_repeat2" /note="CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase; cd04641" /db_xref="CDD:341399" Site order(196,198..200,222..224,294,307,309,311..312,315) /site_type="other" /note="ligand binding site II [chemical binding]" /db_xref="CDD:341399" Region 196..261 /region_name="CBS repeat" /note="CBS repeat [structural motif]" /db_xref="CDD:341399" Site order(222,235,239..240,243,272,294..296,311) /site_type="other" /note="ligand binding site I [chemical binding]" /db_xref="CDD:341399" Region 272..315 /region_name="CBS repeat" /note="CBS repeat [structural motif]" /db_xref="CDD:341399" CDS 1..322 /gene="SNF4" /locus_tag="YGL115W" /gene_synonym="CAT3; SCI1" /coded_by="NM_001180980.1:1..969" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2481228|PMID:17237508]" /experiment="EXISTENCE:direct assay:GO:0005641 nuclear envelope lumen [PMID:17237508]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:2481228|PMID:17237508]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12562756]" /experiment="EXISTENCE:direct assay:GO:0031588 nucleotide-activated protein kinase complex [PMID:12393914|PMID:2481228]" /experiment="EXISTENCE:genetic interaction:GO:0004679 AMP-activated protein kinase activity [PMID:2557546]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:2557546]" /experiment="EXISTENCE:genetic interaction:GO:0043539 protein serine/threonine kinase activator activity [PMID:2557546]" /experiment="EXISTENCE:mutant phenotype:GO:0004679 AMP-activated protein kinase activity [PMID:2557546|PMID:11486005|PMID:7913470]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:31962153]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:1355328]" /experiment="EXISTENCE:mutant phenotype:GO:0043539 protein serine/threonine kinase activator activity [PMID:11486005|PMID:2557546]" /experiment="EXISTENCE:mutant phenotype:GO:0045722 positive regulation of gluconeogenesis [PMID:2481228]" /experiment="EXISTENCE:physical interaction:GO:0031588 nucleotide-activated protein kinase complex [PMID:9121458|PMID:2481228]" /experiment="EXISTENCE:physical interaction:GO:0045722 positive regulation of gluconeogenesis [PMID:2481228]" /note="Activating gamma subunit of the AMP-activated Snf1p kinase complex; additional subunits of the complex are Snf1p and a Sip1p/Sip2p/Gal83p family member; activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852763" /db_xref="SGD:S000003083" ORIGIN 1 mkptqdsqek vsieqqlave sirkflnskt sydvlpvsyr livldtsllv kkslnvllqn 61 sivsaplwds ktsrfagllt ttdfinviqy yfsnpdkfel vdklqldglk dieralgvdq 121 ldtasihpsr plfeaclkml esrsgripli dqdeethrei vvsvltqyri lkfvalncre 181 thflkipigd lniitqdnmk scqmttpvid viqmltqgrv ssvpiideng ylinvyeayd 241 vlglikggiy ndlslsvgea lmrrsddfeg vytctkndkl stimdnirka rvhrffvvdd 301 vgrlvgvltl sdilkyillg sn // LOCUS NP_011401 725 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL114W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011401 VERSION NP_011401.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180979.1 REFERENCE 1 (residues 1 to 725) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 725) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 725) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 725) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07994. Method: conceptual translation. FEATURES Location/Qualifiers source 1..725 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..725 /product="uncharacterized protein" /calculated_mol_wt="79878" Region 8..722 /region_name="OPT_sfam" /note="oligopeptide transporter, OPT superfamily; TIGR00728" /db_xref="CDD:273236" CDS 1..725 /locus_tag="YGL114W" /coded_by="NM_001180979.1:1..2178" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /note="hypothetical protein; predicted member of the oligopeptide transporter (OPT) family of membrane transporters" /db_xref="GeneID:852764" /db_xref="SGD:S000003082" ORIGIN 1 mpqstpsqev qrvpwdnkpa lkqitlrati agiaigslvl tsnfqfglqt gwvsmmslps 61 allacaffkn iwplifpndr pfsdvenvyv qsmavavgtg plafgfvgvi paiekfltnd 121 esgglreqgq sftfrelliw stalaffgif favplrkqvi vreklpfpsg satatlisvl 181 ngteilqevs ksellemrqr rlnecpevlq pnrdpeeady lmnsshselg dytatsqdgs 241 silstgseny raniiillkt fvvsslytmv syfvpvirsi pvfgkylsnn ylwnfqpspa 301 yigqgiimgl ptvsymligc flgwgvlapl arykrwvppd advhdweegv qgwilwssls 361 imvadsvvaf ivvtvksivk filiddkaal lnniiddtfq smlleeerai nssrrntyvd 421 grqdtvrlvs rdneievdsk hlvryttvis gclvssiici vsiiylfgiq viplyaiita 481 lilalflsil giralgetdl npvsgigkis qlifafiipr drpgsvlmnv vsggiaeasa 541 qqagdlmqdl ktghllgasp raqfcaqlig acwsiilssf mylcynkvys ipseqfript 601 avvwidcarl vtgkglpdka lecsmilgvi favlslirnt yrdygygwil yipsgvavgv 661 gifnspsfti arfiggwash fwlknhrgdl naktkmivfs sglvlgegif svinmlficl 721 nvphy // LOCUS NP_011402 668 aa linear PLN 30-JUN-2025 DEFINITION Sld3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011402 VERSION NP_011402.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180978.3 REFERENCE 1 (residues 1 to 668) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 668) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 668) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 668) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07995. On Jul 30, 2012 this sequence version replaced NP_011402.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..668 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..668 /product="Sld3p" /calculated_mol_wt="77167" Region 5..121 /region_name="Sld3_N" /note="Sld3 N-terminal domain; pfam18523" /db_xref="CDD:408310" Region 157..646 /region_name="SLD3" /note="DNA replication regulator SLD3; pfam08639" /db_xref="CDD:400803" CDS 1..668 /gene="SLD3" /locus_tag="YGL113W" /coded_by="NM_001180978.3:1..2007" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23746350]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:11296242]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11296242]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:11296242]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:11296242]" /experiment="EXISTENCE:physical interaction:GO:0031261 DNA replication preinitiation complex [PMID:11296242]" /note="Protein involved in the initiation of DNA replication; required for proper assembly of replication proteins at the origins of replication; interacts with the DDK-phosphorylated MCM complex and required for the recruitment of Cdc45p; localizes to nuclear foci that become diffuse upon DNA replication stress; homologous to the human Treslin/Ticrr protein" /db_xref="GeneID:852765" /db_xref="SGD:S000003081" ORIGIN 1 metweviasv keatkgldls ldhpliikse dvpsnilqll qqknrrqlkh icmksrkeyf 61 lleeygpgfw vkwpynyfng yslperrtev vttvererak retlktwdel kfkellhlws 121 eepkgsckle kdkdlkldmn ppdmkgeski ndyysdpkey ieskyydalf sihtplayfv 181 ksnlvrlknt crtkygsdsy kiayqamlqk fllsivqfkd rhdnrlllep fsspiadekr 241 kncltkfviq denknsstia dlcvvlksre iklqilllle iiglndldwn frdfekkykl 301 klkkrslnlt kkglvrrrsk kktsekdkgi erittsldyc eqldlyldra cildillsse 361 tpnpdaieas ngtiqehkkn ildkskeasl vgfinyvlip yfnkkvphav efiiqklkgp 421 smrpkralkk vndstnvssp ntvetynrls tsqrasrssi insvpsspal rrvdanlfsr 481 ksiasptpel lnsrtnsnln eflesetrsl krpsqlgrtk sdltmnhlqk rqfsvsdlst 541 trvpnsstit lktpfshsti nayktmnnsf rrvgkrkdin etirlhervd seenvqvqat 601 pavkkrtvtp nkkaqlqsii esplnfkddd thegrkntsn itstptnkpp ensskrrvrr 661 rlfapest // LOCUS NP_011403 516 aa linear PLN 30-JUN-2025 DEFINITION TATA-binding protein-associated factor TAF6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011403 VERSION NP_011403.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180977.1 REFERENCE 1 (residues 1 to 516) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 516) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 516) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 516) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07996. Method: conceptual translation. FEATURES Location/Qualifiers source 1..516 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..516 /product="TATA-binding protein-associated factor TAF6" /calculated_mol_wt="57771" Region 6..513 /region_name="TAF6" /note="Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]; COG5095" /db_xref="CDD:227426" CDS 1..516 /gene="TAF6" /locus_tag="YGL112C" /gene_synonym="TAF60" /coded_by="NM_001180977.1:1..1551" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10817999]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:9844639]" /experiment="EXISTENCE:mutant phenotype:GO:2000144 positive regulation of DNA-templated transcription initiation [PMID:29485702]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]" /note="Subunit (60 kDa) of TFIID and SAGA complexes; involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852766" /db_xref="SGD:S000003080" ORIGIN 1 mstqqqsyti wspqdtvkdv aeslglenin ddvlkalamd veyrileiie qavkfkrhsk 61 rdvlttddvs kalrvlnvep lygyydgsev nkavsfskvn tsggqsvyyl deeevdfdrl 121 ineplpqvpr lptftthwla vegvqpaiiq npnlndirvs qppfirgaiv talndnslqt 181 pvtsttasas vtdtgasqhl snvkpgqnte vkplvkhvls kelqiyfnkv istltaksqa 241 deaaqhmkqa altslrtdsg lhqlvpyfiq fiaeqitqnl sdlqllttil emiysllsnt 301 sifldpyihs lmpsiltlll akklggspkd dspqeihefl ertnalrdfa aslldyvlkk 361 fpqaykslkp rvtrtllktf ldinrvfgty ygclkgvsvl egesirfflg nlnnwarlvf 421 nesgitldni eehlnddsnp trtkftkeet qilvdtvisa llvlkkdlpd lyegkgekvt 481 dedkekller cgvtigfhil krddakelis aiffge // LOCUS NP_011404 463 aa linear PLN 30-JUN-2025 DEFINITION ribosome biosynthesis protein NSA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011404 VERSION NP_011404.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180976.1 REFERENCE 1 (residues 1 to 463) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 463) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 463) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 463) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07997. Method: conceptual translation. FEATURES Location/Qualifiers source 1..463 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..463 /product="ribosome biosynthesis protein NSA1" /calculated_mol_wt="51776" Region 1..452 /region_name="Nsa1" /note="Ribosome Biogenesis Protein Nsa1; cd22858" /db_xref="CDD:439304" Region 3..42 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:439304" Region 45..116 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:439304" Region 139..186 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:439304" Region 188..234 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:439304" Site order(233,236..238,241,243,271,292..295,351..354,357) /site_type="other" /note="25S rRNA binding site [nucleotide binding]" /db_xref="CDD:439304" Region 249..301 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:439304" Region 303..357 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:439304" Region 361..399 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:439304" Site order(380,382,403) /site_type="other" /note="RPF1 binding site [polypeptide binding]" /db_xref="CDD:439304" CDS 1..463 /gene="NSA1" /locus_tag="YGL111W" /coded_by="NM_001180976.1:1..1392" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350|PMID:23212245]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]" /note="Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis" /db_xref="GeneID:852767" /db_xref="SGD:S000003079" ORIGIN 1 mrllvscvds gsikevlcni gtdtsvqsal qpfhvaphla eglkayvdrm wvisedeail 61 arnsgvvelv kiskhlkene alqvdpkges knekslsddl pkfdisefei tssvsdlfdd 121 akleslssks vkrtklvdgf vtlcpikkds snntfvaatk sgllhiikkg edkkliklas 181 lglkapvefl qlydledtdt dkyifaygge enliklveid ssfqslkqiw eaknvkndrl 241 dmrvpvwpma lrflepspgk tekgklnyqf aaitrwshlt kystqhgrkp faqidllpnr 301 eplsqmevfd akgenvvssl gnfqsetfne lnvittdykk nvfkfdgngr mlgkvgrddi 361 tgsstyihvh dgkyllqggl dryvrifdik tnkmlvkvyv gsrinfivml ddveiempls 421 psakaakgkq krkvteleed adelwnkleg kvaaskaskk ski // LOCUS NP_011405 624 aa linear PLN 30-JUN-2025 DEFINITION Cue3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011405 VERSION NP_011405.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180975.1 REFERENCE 1 (residues 1 to 624) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 624) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 624) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 624) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07998. Method: conceptual translation. FEATURES Location/Qualifiers source 1..624 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..624 /product="Cue3p" /calculated_mol_wt="71912" Region 318..358 /region_name="CUE_Cue3p_like" /note="CUE domain found in yeast ubiquitin-binding protein CUE3 (Cue3p) and similar proteins; cd14373" /db_xref="CDD:270556" CDS 1..624 /gene="CUE3" /locus_tag="YGL110C" /gene_synonym="RQT3" /coded_by="NM_001180975.1:1..1875" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:36627279]" /experiment="EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12628920]" /experiment="EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:36627279]" /experiment="EXISTENCE:direct assay:GO:0072344 rescue of stalled ribosome [PMID:36627279|PMID:30893611]" /experiment="EXISTENCE:mutant phenotype:GO:0072344 rescue of stalled ribosome [PMID:28757607]" /note="Subunit of ribosome-associated quality control trigger complex (RQT); has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination" /db_xref="GeneID:852768" /db_xref="SGD:S000003078" ORIGIN 1 mlsrynrvie inggnadisl pivkfppfkl raqliekdpv vwlhlietyv tyfeylmqga 61 nvelldestl dhlrlflrty lheiadeegk llslginhdv seqlyllkgw ifslikkcgl 121 lhlqifgdsl wnlikvyvrr npdsirglid gslkprintq rvqldksyqv qqhlkqlies 181 gkfkridlrc vedllsaksm qpnkfaenff tanwieilea lwakgqgrgh keareliiis 241 lfsvsadrll kitkelgisn fetlalypll gtmlinegvh krlpdlkskl lflnlgglsm 301 degdhmsypt ssgtevneeq lsalmelfpq fskyqlsqtl laydnnielv tnkifedpti 361 ieafsrepae eevepvsdgd nasfteelsi ldrgdssknk eldkkiiseg vpdelrnktl 421 tralkllyea dederddtyd eadvnrsdps kriglqedee sydtkddsne vrqdhnyhiv 481 eaylwnllke dpklferskr gtkvrktmke mtswsdekie gwcrmlersp trarllekkf 541 mfkgnsktgk tsyvhnrdsq ndgnvvkeqa kqkksenikk hepqsteqkk rqhaknekrk 601 garanhnrkk ghdkklarag nnai // LOCUS NP_011407 140 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL108C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011407 VERSION NP_011407.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180973.3 REFERENCE 1 (residues 1 to 140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 140) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA07999. On Jul 30, 2012 this sequence version replaced NP_011407.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..140 /product="uncharacterized protein" /calculated_mol_wt="15906" CDS 1..140 /locus_tag="YGL108C" /coded_by="NM_001180973.3:1..423" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein, predicted to be palmitoylated; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol, while N-terminal GFP fusion protein localizes to the cell periphery; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852770" /db_xref="SGD:S000003076" ORIGIN 1 mglcgsktqp mpsqtttvat kartkpinrd tvkskqelrh kekkdkkkkt qlksttvpvv 61 qrkegskltd tsdpsknkvs pkeaarlaae krfqetneky nkgelgkkla qerakshktr 121 lmeeaekkha ererenmiyd // LOCUS NP_011408 646 aa linear PLN 30-JUN-2025 DEFINITION Rmd9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011408 VERSION NP_011408.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180972.1 REFERENCE 1 (residues 1 to 646) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 646) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 646) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 646) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08000. Method: conceptual translation. FEATURES Location/Qualifiers source 1..646 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..646 /product="Rmd9p" /calculated_mol_wt="74465" Region 290..317 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 320..353 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 363..392 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" CDS 1..646 /gene="RMD9" /locus_tag="YGL107C" /coded_by="NM_001180972.1:1..1941" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003730 mRNA 3'-UTR binding [PMID:33876744]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17194786|PMID:14562095|PMID:24769239|PMID:14576278|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0090615 mitochondrial mRNA processing [PMID:33876744]" /experiment="EXISTENCE:direct assay:GO:1903108 regulation of mitochondrial transcription [PMID:33876744]" /experiment="EXISTENCE:genetic interaction:GO:0006413 translational initiation [PMID:17194786]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:17194786|PMID:17194787]" /experiment="EXISTENCE:mutant phenotype:GO:0043488 regulation of mRNA stability [PMID:17194787]" /note="Mitochondrial protein that controls mitochondrial gene expression; binds the dodecamer element in mitochondrial mRNAs, facilitates processing and delivery of mitochondrial mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes; RMD9 has a paralog, YBR238C, that arose from the whole genome duplication" /db_xref="GeneID:852771" /db_xref="SGD:S000003075" ORIGIN 1 mmlrrnavrs lktmeisvsn vvnsgsiaml rgklanvvls drtyhsspif hknvpkgvld 61 kkngreqrkt eqnvfnvdpa spwrhellsf decvssalky sttplqntyk rignnqlnkn 121 psfamfwdsm gramelyysl respdfnayr vsrlihllhn glrstrdqlv klsrkpdyds 181 qsfhkemmnf lcnslkdisd diligkvsvs gygathllts fkelsfdddc iriweasknl 241 sdettsqafq epkvvgfmlp llyaktrslt epnelynqii qskefihpnl ysglikvfik 301 aedyekalsl fgqlcekaev rnygylieth lsfigdsknl tlaesffdki indempykii 361 lqvstvnsfl qniwkaqndf dhvyriweka vkfygntvnp gilsslnntf ftiffenyin 421 dningfrklq eiitfysgvk kidepffnvm ltrasiwher siidfidkny tlyhiprtii 481 syrillkslg sidntnneei ldrwlelvkk lnelgqqyia nadlsalrda tvvwsqskrd 541 ekvfsakakg tpattttted dikvpkplen lknedstsns edrielylki lkrytpyfra 601 tkqvyryttg caesypilne ylsgysdlsa edipvpqlhs fiakeq // LOCUS NP_011409 149 aa linear PLN 30-JUN-2025 DEFINITION Mlc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011409 VERSION NP_011409.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180971.1 REFERENCE 1 (residues 1 to 149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 149) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08001. Method: conceptual translation. FEATURES Location/Qualifiers source 1..149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..149 /product="Mlc1p" /calculated_mol_wt="16313" Region 8..143 /region_name="PTZ00184" /note="calmodulin; Provisional" /db_xref="CDD:185504" CDS 1..149 /gene="MLC1" /locus_tag="YGL106W" /coded_by="NM_001180971.1:1..450" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:11082046]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15210731]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10873803|PMID:15210731]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:10873803]" /experiment="EXISTENCE:direct assay:GO:0031489 myosin V binding [PMID:9700160]" /experiment="EXISTENCE:direct assay:GO:0031982 vesicle [PMID:12456647]" /experiment="EXISTENCE:direct assay:GO:0120155 MIH complex [PMID:24895401]" /experiment="EXISTENCE:genetic interaction:GO:1903476 protein localization to cell division site involved in mitotic actomyosin contractile ring assembly [PMID:10873803]" /experiment="EXISTENCE:mutant phenotype:GO:0006903 vesicle targeting [PMID:12456647]" /experiment="EXISTENCE:mutant phenotype:GO:1903476 protein localization to cell division site involved in mitotic actomyosin contractile ring assembly [PMID:10873803|PMID:11082046]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:11082046|PMID:10873803|PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0016460 myosin II complex [PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0032038 myosin II heavy chain binding [PMID:11082046|PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0120155 MIH complex [PMID:24895401|PMID:24413167]" /note="Essential light chain for Myo1p; light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition" /db_xref="GeneID:852772" /db_xref="SGD:S000003074" ORIGIN 1 msatrankdi ftlfdkkgqg aiakdslgdy lraigynptn qlvqdiinad sslrdasslt 61 ldqitgliev nekeldattk aktedfvkaf qvfdkestgk vsvgdlryml tglgekltda 121 evdellkgve vdsngeidyk kfiedvlrq // LOCUS NP_011410 376 aa linear PLN 30-JUN-2025 DEFINITION Arc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011410 VERSION NP_011410.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180970.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08002. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..376 /product="Arc1p" /calculated_mol_wt="41953" Region 22..119 /region_name="GST_C_Arc1p_N_like" /note="Glutathione S-transferase C-terminal-like, alpha helical domain of the Aminoacyl tRNA synthetase cofactor 1 and similar proteins; cd10304" /db_xref="CDD:198337" Site order(22..23,25..27,29..34,36..37,43,46,52..53) /site_type="other" /note="MetRS interface [polypeptide binding]" /db_xref="CDD:198337" Site order(51..55,59..60,96..97,99..100,104,107..108,119) /site_type="other" /note="GluRS interface [polypeptide binding]" /db_xref="CDD:198337" Region <193..376 /region_name="PLN02610" /note="probable methionyl-tRNA synthetase" /db_xref="CDD:215329" CDS 1..376 /gene="ARC1" /locus_tag="YGL105W" /coded_by="NM_001180970.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0002161 aminoacyl-tRNA deacylase activity [PMID:40274265]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15710377|PMID:11726524]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:11069915]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26359986|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:16343487]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:16343487]" /experiment="EXISTENCE:mutant phenotype:GO:0000049 tRNA binding [PMID:11726524]" /experiment="EXISTENCE:mutant phenotype:GO:0006418 tRNA aminoacylation for protein translation [PMID:9659920]" /experiment="EXISTENCE:mutant phenotype:GO:0017102 methionyl glutamyl tRNA synthetase complex [PMID:9659920]" /note="Protein that binds tRNA and both methionyl- and glutamyl-tRNA synthetases; forms a complex with methionyl-tRNA synthetase Mes1p (MetRS) and glutamyl-tRNA synthetase Gus1p (GluRS); recruits tRNA to the complex, increases aminoacylation efficiency by stimulating catalysis and ensures cytoplasmic localization of the complex; OB-fold containing protein with unexpected aminoacyl-tRNA deacylase activity; binds quadruplex nucleic acids; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852773" /db_xref="SGD:S000003073" ORIGIN 1 msdlvtkfes liiskypvsf tkeqsaqaaq wesvlksgqi qphldqlnlv lrdntfivst 61 lyptstdvhv fevalplikd lvasskdvks tyttyrhilr widymqnlle vsstdklein 121 hdldlphevi ekkkkapagg aadaaakade dvskkakkqd hprgkpdeet lkklreeaka 181 kkaakkaana kqqqeqqnka pekpkpsaid frvgfiqkai khpdadslyv stidvgdeeg 241 prtvcsglvk hfpldamqer yvvvvcnlkp vnmrgiksta mvlcgsnddk vefveppkds 301 kagdkvffeg fgdeapmkql npkkkiwehl qphfttndgl evifkdeeek dhpvrkltna 361 kgesfkvasi anaqvr // LOCUS NP_011411 486 aa linear PLN 30-JUN-2025 DEFINITION putative sugar transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_011411 VERSION NP_011411.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180969.3 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08003. On Jul 30, 2012 this sequence version replaced NP_011411.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..486 /product="putative sugar transporter" /calculated_mol_wt="54200" Region 31..484 /region_name="MFS_GLUT_Class1_2_like" /note="Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; cd17357" /db_xref="CDD:340915" Site order(42,46,184,187..188,191,314..315,319..320,323,349, 406..407,411,415,438,442) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340915" CDS 1..486 /gene="VPS73" /locus_tag="YGL104C" /coded_by="NM_001180969.3:1..1461" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /note="Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family; VPS73 has a paralog, YBR241C, that arose from the whole genome duplication" /db_xref="GeneID:852774" /db_xref="SGD:S000003072" ORIGIN 1 mnrilssasl lsnvsmprqn khkitkalcy aiivasigsi qfgyhlseln apqqvlscse 61 fdipmegypy drtwlgkrgy kqciplndeq igivtsvfci ggilgsyfat slaniygrkf 121 sslinctlni vgsliifnsn syrgliigri lvgiscgsli viiplfikev apsgwegllg 181 smtqicirlg vlltqgialp ltdsyrwrwi lfgsfliavl nffmwfivde spkwllahgr 241 vtdaklslck lrgvtfdeaa qeiqdwqlqi esgdpliept ttnsisgsns lwkylrdrtn 301 vksrhvitvl lfgqqfcgin sivlygtkii sqlypqhair inffismvnv lvtilvslli 361 hslprkpllm tstvlvsvta fimgiamnhn kmnllivfsf iymgvftmgl nplpfiimre 421 vskpqdmvla qrygticnwv gtfiiaytfp iihdvlsgyv fiifaiiacs isafiwkkvp 481 etkrsg // LOCUS NP_011412 149 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL15 RPL28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011412 VERSION NP_011412.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180968.1 REFERENCE 1 (residues 1 to 149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 149) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08004. Method: conceptual translation. FEATURES Location/Qualifiers source 1..149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..149 /product="60S ribosomal protein uL15 RPL28" /calculated_mol_wt="16590" Region 1..149 /region_name="PTZ00160" /note="60S ribosomal protein L27a; Provisional" /db_xref="CDD:185489" CDS 1..149 /gene="RPL28" /locus_tag="YGL103W" /gene_synonym="CYH2" /coded_by="NM_001180968.1:1..450" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:22096102]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:2104804]" /note="Ribosomal 60S subunit protein L28; homologous to mammalian ribosomal protein L27A and bacterial L15; may have peptidyl transferase activity; can mutate to cycloheximide resistance" /db_xref="GeneID:852775" /db_xref="SGD:S000003071" ORIGIN 1 mpsrftktrk hrghvsagkg rigkhrkhpg grgmaggqhh hrinmdkyhp gyfgkvgmry 61 fhkqqahfwk pvlnldklwt lipedkrdqy lksasketap vidtlaagyg kilgkgripn 121 vpvivkarfv sklaeekira aggvvelia // LOCUS NP_011414 215 aa linear PLN 30-JUN-2025 DEFINITION 5'-deoxynucleotidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011414 VERSION NP_011414.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180966.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08005. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..215 /product="5'-deoxynucleotidase" /EC_number="3.1.3.89" /calculated_mol_wt="25166" Region 39..185 /region_name="HD_3" /note="HD domain; pfam13023" /db_xref="CDD:432939" CDS 1..215 /gene="YGK1" /locus_tag="YGL101W" /coded_by="NM_001180966.1:1..648" /experiment="EXISTENCE:direct assay:GO:0002953 5'-deoxynucleotidase activity [PMID:29752939]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008253 5'-nucleotidase activity [PMID:29752939]" /experiment="EXISTENCE:direct assay:GO:0009159 deoxyribonucleoside monophosphate catabolic process [PMID:29752939]" /note="5'-deoxynucleotidase; non-essential gene involved in deoxyribonucleoside monophosphate degradation; interacts with the DNA helicase Hpr5p; YGL101W has a paralog, YBR242W, that arose from the whole genome duplication" /db_xref="GeneID:852777" /db_xref="SGD:S000003069" ORIGIN 1 mtavniwkpe dnipreilai lskphpnyql aflniiqllk tqrrtgwvdh gidpcesisd 61 hmyrmglttm litdknvdrn kcirialvhd faeslvgdit pndpmtkeek hrrefetvky 121 lcesiirpcs esasreildd wlayekqtcl egryvkdidk yemlvqcfey eqkyngkkdl 181 kqflgaindi ktdevkkwtq slledrqaff dslke // LOCUS NP_011415 349 aa linear PLN 30-JUN-2025 DEFINITION Seh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011415 VERSION NP_011415.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180965.1 REFERENCE 1 (residues 1 to 349) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 349) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 349) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 349) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08006. Method: conceptual translation. FEATURES Location/Qualifiers source 1..349 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..349 /product="Seh1p" /calculated_mol_wt="38992" Region <7..334 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 13..53 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 58..105 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 112..158 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 165..207 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 215..262 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 307..346 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..349 /gene="SEH1" /locus_tag="YGL100W" /coded_by="NM_001180965.1:1..1050" /experiment="EXISTENCE:curator inference:GO:0017056 structural constituent of nuclear pore [PMID:11823431]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:11823431|PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]" /experiment="EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:23974112]" /note="Subunit of the Nup84 nuclear pore and SEACAT subcomplexes; involved in nucleocytoplasmic transport and NPC biogenesis in the nuclear pore subcomplex; subunit of SEACAT, a subcomplex of the SEA complex that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; human SEH1 homolog" /db_xref="GeneID:852778" /db_xref="SGD:S000003068" ORIGIN 1 mqpfdsghdd lvhdvvydfy grhvatcssd qhikvfkldk dtsnwelsds wrahdssiva 61 idwaspeygr iiasasydkt vklweedpdq eecsgrrwnk lctlndskgs lysvkfapah 121 lglklaclgn dgilrlydal epsdlrswtl tsemkvlsip panhlqsdfc lswcpsrfsp 181 eklavsaleq aiiyqrgkdg klhvaaklpg hkslirsisw apsigrwyql iatgckdgri 241 rifkitekls plaseesltn snmfdnsadv dmdaqgrsds nteekaelqs nlqvellseh 301 ddhngevwsv swnltgtils sagddgkvrl wkatysnefk cmsvitaqq // LOCUS NP_011416 640 aa linear PLN 30-JUN-2025 DEFINITION ribosome biogenesis GTPase LSG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011416 VERSION NP_011416.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180964.3 REFERENCE 1 (residues 1 to 640) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 640) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 640) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 640) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08007. On Jul 30, 2012 this sequence version replaced NP_011416.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..640 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..640 /product="ribosome biogenesis GTPase LSG1" /calculated_mol_wt="72597" Region 187..394 /region_name="HSR1_MMR1" /note="A circularly permuted subfamily of the Ras GTPases; cd01857" /db_xref="CDD:206750" Region 199..496 /region_name="RbgA" /note="Ribosome biogenesis GTPase RbgA [Translation, ribosomal structure and biogenesis]; COG1161" /db_xref="CDD:440775" Site order(236..237,239..240,264..266,345..351,390) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206750" Site 236..239 /site_type="other" /note="G4 box" /db_xref="CDD:206750" Site 264..266 /site_type="other" /note="G5 box" /db_xref="CDD:206750" Site 343..350 /site_type="other" /note="G1 box" /db_xref="CDD:206750" Site 368..375 /site_type="other" /note="Switch I region" /db_xref="CDD:206750" Site 371 /site_type="other" /note="G2 box" /db_xref="CDD:206750" Site 387..390 /site_type="other" /note="G3 box" /db_xref="CDD:206750" Site 389..391 /site_type="other" /note="Switch II region" /db_xref="CDD:206750" CDS 1..640 /gene="LSG1" /locus_tag="YGL099W" /gene_synonym="KRE35" /coded_by="NM_001180964.3:1..1923" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12773575]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:12773575]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:20670889]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:12773575]" /note="Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm" /db_xref="GeneID:852779" /db_xref="SGD:S000003067" ORIGIN 1 mppkeapkkw kapkgpkpth rknknklelg raikyarqke naieylpdge mrfttdkhea 61 nwvklrsvtq esaldeflst aaladkdfta drhsnvkiir mdsgndsats qgfsmtneqr 121 gnlnakqral akdlivprrp ewnegmskfq ldrqekeafl ewrrklahlq esnedllltp 181 fernievwkq lwrvversdl vvqivdarnp llfrsvdler yvkesddrka nlllvnkadl 241 ltkkqriawa kyfisknisf tfysalranq llekqkemge dyreqdfeea dkegfdadek 301 vmekvkilsi dqleelflsk apnepllppl pgqpplinig lvgypnvgks stinslvgak 361 kvsvsstpgk tkhfqtikls dsvmlcdcpg lvfpnfaynk gelvcngvlp idqlrdyigp 421 aglvaeripk yyieaiygih iqtksrdegg ngdiptaqel lvayarargy mtqgygsade 481 prasryilkd yvngkllyvn ppphleddtp ytreeceefn kdlyvfdrlp dtrkeqvqna 541 akakgidivd lardlnqltf sahtggdtqk eaksvthggk qaalynaaed ldrdffkmnn 601 vegrlstpfh kvqnssagkr hnkknkskna kskvfsienn // LOCUS NP_011417 245 aa linear PLN 30-JUN-2025 DEFINITION SNAP receptor USE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011417 VERSION NP_011417.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180963.1 REFERENCE 1 (residues 1 to 245) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 245) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 245) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 245) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08008. Method: conceptual translation. FEATURES Location/Qualifiers source 1..245 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..245 /product="SNAP receptor USE1" /calculated_mol_wt="27976" Region <74..230 /region_name="Use1" /note="Membrane fusion protein Use1; pfam09753" /db_xref="CDD:462882" Region 151..210 /region_name="SNARE_USE1" /note="SNARE motif of USE1; cd15860" /db_xref="CDD:277213" Site order(156..159,161..163,165..167,169..170,172..177, 179..180,183,186..187,189..191,193..195,197..198,200..201, 204..205,207..208,210) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277213" Site 183 /site_type="other" /note="zero layer" /db_xref="CDD:277213" CDS 1..245 /gene="USE1" /locus_tag="YGL098W" /gene_synonym="SLT1" /coded_by="NM_001180963.1:1..738" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:12853481]" /experiment="EXISTENCE:direct assay:GO:0098554 cytoplasmic side of endoplasmic reticulum membrane [PMID:12893879]" /experiment="EXISTENCE:mutant phenotype:GO:0005484 SNAP receptor activity [PMID:12853481]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:12853481|PMID:12893879]" /experiment="EXISTENCE:physical interaction:GO:0005484 SNAP receptor activity [PMID:12853481]" /note="Essential SNARE protein localized to the ER; involved in retrograde traffic from the Golgi to the ER and Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p" /db_xref="GeneID:852780" /db_xref="SGD:S000003066" ORIGIN 1 maetsndpfl syvlsskqlt nlnrlrrkav tkqlgssddn kvseeflryq htyqreafey 61 lqtkhdahki mesqyeqyqs ssktrrysid ldsvdavdte sqteypneef idrnedseav 121 melrkrllgk gqnkglgyet tksvdrqied qdtlqqdliq dmsklvgslk qgavafqsal 181 dedkqvlgaa eigiqvasqg lmdvsgklrk ydksklsylf yitvfifmil glvftfiiiq 241 lfpal // LOCUS NP_011418 482 aa linear PLN 30-JUN-2025 DEFINITION Ran guanyl-nucleotide exchange factor [Saccharomyces cerevisiae S288C]. ACCESSION NP_011418 VERSION NP_011418.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180962.1 REFERENCE 1 (residues 1 to 482) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 482) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 482) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 482) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08009. Method: conceptual translation. FEATURES Location/Qualifiers source 1..482 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..482 /product="Ran guanyl-nucleotide exchange factor" /calculated_mol_wt="52883" Region 48..439 /region_name="ATS1" /note="Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5184" /db_xref="CDD:444065" CDS 1..482 /gene="SRM1" /locus_tag="YGL097W" /gene_synonym="MTR1; PRP20; TSM437" /coded_by="NM_001180962.1:1..1449" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16365162]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1865879|PMID:11024003|PMID:1666302]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11024003]" /experiment="EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:1865879]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:11739405]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:11024003]" /experiment="EXISTENCE:mutant phenotype:GO:0006997 nucleus organization [PMID:8455603]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:27385342]" /note="Nucleotide exchange factor for Gsp1p; localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p; human homolog of the RAN GEF, RCC1, can complement a temperature sensitive point mutant" /db_xref="GeneID:852782" /db_xref="SGD:S000003065" ORIGIN 1 mvkrtvatng dasgahrakk mskthashii naqedykhmy lsvqpldifc wgtgsmcelg 61 lgplaknkev krprlnpflp rdeakiisfa vggmhtlald eesnvwswgc ndvgalgrdt 121 snakeqlkdm daddssdded gdlnelestp akipresfpp laeghkvvql aatdnmscal 181 fsngevyawg tfrcnegilg fyqdkikiqk tpwkvptfsk ynivqlapgk dhilfldeeg 241 mvfawgngqq nqlgrkvmer frlktldprp fglrhvkyia sgenhcfalt kdnklvswgl 301 nqfgqcgvse dvedgalvtk pkrlalpdnv virsiaageh hslilsqdgd lyscgrldmf 361 evgipkdnlp eytykdvhgk aravplptkl nnvpkfksva agshhsvava qngiayswgf 421 getyavglgp feddtevptr ikntatqdhn iilvgcggqf svsggvklsd edaekradem 481 dd // LOCUS NP_011419 276 aa linear PLN 30-JUN-2025 DEFINITION Tos8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011419 VERSION NP_011419.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180961.1 REFERENCE 1 (residues 1 to 276) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 276) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 276) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 276) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08010. Method: conceptual translation. FEATURES Location/Qualifiers source 1..276 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..276 /product="Tos8p" /calculated_mol_wt="31126" Site order(197,200,243,246..247,250) /site_type="other" /note="specific DNA base contacts [nucleotide binding]" /db_xref="CDD:238039" Region 213..251 /region_name="Homeobox_KN" /note="Homeobox KN domain; pfam05920" /db_xref="CDD:428673" CDS 1..276 /gene="TOS8" /locus_tag="YGL096W" /coded_by="NM_001180961.1:1..831" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12464632]" /note="Homeodomain-containing protein and putative transcription factor; found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; TOS8 has a paralog, CUP9, that arose from the whole genome duplication" /db_xref="GeneID:852783" /db_xref="SGD:S000003064" ORIGIN 1 mgtsivnlnq kielppiqvl feslnrenet kphfeerrly qpnpsfvprt niavgspvnp 61 vpvsspvffi gpspqrsiqn hnaimtqnir qypviynnnr evistgerny iitvggppvt 121 ssqpeyehis tpnfyqeqrl aqphpvnesm miggytnpqp isisrgkmls gnistnsvrg 181 snngysakek khkahgkrsn lpkatvsiln kwlhehvnnp yptvqekrel laktgltklq 241 isnwfinarr rkifsgqnda nnfrrkfsss tnlakf // LOCUS NP_011420 577 aa linear PLN 30-JUN-2025 DEFINITION Vps45p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011420 VERSION NP_011420.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180960.3 REFERENCE 1 (residues 1 to 577) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 577) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 577) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 577) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08011. On Jul 30, 2012 this sequence version replaced NP_011420.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..577 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..577 /product="Vps45p" /calculated_mol_wt="66887" Region 3..577 /region_name="SEC1" /note="Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion]; COG5158" /db_xref="CDD:227487" CDS 1..577 /gene="VPS45" /locus_tag="YGL095C" /gene_synonym="STT10; VPL28" /coded_by="NM_001180960.3:1..1734" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:7720726]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9624182]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:9335586]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:7628704]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:7720726]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:9650782]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:7628704]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:10545112]" /experiment="EXISTENCE:mutant phenotype:GO:0035543 positive regulation of SNARE complex assembly [PMID:11432826]" /experiment="EXISTENCE:mutant phenotype:GO:0048210 Golgi vesicle fusion to target membrane [PMID:9650782]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:11432826]" /experiment="EXISTENCE:physical interaction:GO:0000149 SNARE binding [PMID:16769821]" /experiment="EXISTENCE:physical interaction:GO:0031201 SNARE complex [PMID:10397773]" /experiment="EXISTENCE:physical interaction:GO:0051082 unfolded protein binding [PMID:11432826]" /note="Protein of the Sec1p/Munc-18 family; essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment; mutation in human VPS45 is associated with congenital neutropenia and primary myelofibrosis of infancy" /db_xref="GeneID:852785" /db_xref="SGD:S000003063" ORIGIN 1 mnlfdvadfy inkivtsqsk lsvanvnehq rikvllldkn ttptislcat qsellkheiy 61 lverieneqr evsrhlrclv yvkpteetlq hllrelrnpr ygeyqiffsn ivsksqlerl 121 aesddleavt kveeifqdff ilnqdlfsfd lqpreflsnk lvwseggltk ctnslvsvll 181 slkikpdiry egaskicerl akevsyeigk nertffdfpv mdstpvllil drntdpitpl 241 lqpwtyqsmi neyigikrni vdlskvprid kdlekvtlss kqdaffrdtm ylnfgelgdk 301 vkqyvttykd ktqtnsqins iediknfiek ypefrklsgn vakhmaivge ldrqlkikni 361 weiseieqnl sahdaneedf sdlikllqne avdkyyklkl aciyslnnqt ssdkirqlve 421 ilsqqlpped vnffhkfksl fsrqdkmtqs nhdkddilte larrfnsrmn sksntaenvy 481 mqhipeissl ltdlsknalf rdrfkeidtq ghrvignqqs kdipqdvilf viggvtyeea 541 rlvhdfngtm nnrmrvvlgg tsilstkeym dsirsak // LOCUS NP_011421 1115 aa linear PLN 30-JUN-2025 DEFINITION poly(A)-specific ribonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_011421 VERSION NP_011421.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180959.1 REFERENCE 1 (residues 1 to 1115) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1115) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1115) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1115) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08012. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1115 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1115 /product="poly(A)-specific ribonuclease" /EC_number="3.1.13.4" /calculated_mol_wt="126909" Region <168..>328 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 505..829 /region_name="UCH_1" /note="Ubiquitin carboxyl-terminal hydrolase; pfam13423" /db_xref="CDD:463872" Region 907..1080 /region_name="PAN2_exo" /note="DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2; cd06143" /db_xref="CDD:99846" Site order(910..913,915,972,976,1015..1016,1018..1020,1066,1071) /site_type="active" /db_xref="CDD:99846" Site order(910..913,915,972,976,1015..1016,1018..1019,1066,1071) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:99846" Site order(910,912,1020,1066,1071) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:99846" CDS 1..1115 /gene="PAN2" /locus_tag="YGL094C" /coded_by="NM_001180959.1:1..3348" /experiment="EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:8550599]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031251 PAN complex [PMID:8816488]" /experiment="EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:11953437]" /experiment="EXISTENCE:mutant phenotype:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:8550599]" /experiment="EXISTENCE:mutant phenotype:GO:0004535 poly(A)-specific ribonuclease activity [PMID:8550599]" /note="Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; complex acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes" /db_xref="GeneID:852786" /db_xref="SGD:S000003062" ORIGIN 1 mnnwqhffnn pvdlsehlkk pyfrfdnrdk eitaisfdek anliwsgdsy gcissydptf 61 qlytryrghi ggnsvkdils hrdgilsise dslhfanrrg vtklnltsid iaafselntm 121 cysphslknn iycggdntnw giasidlnrg cldsllnyss kvklmcsnnk vlsigrqtgt 181 vdlldptsnr tiksfnahsa sisamdlrdn tlvtvgkskr fynlyadpfv nvydlrtmrq 241 lppvsfskgt tmgsggadfv qlhpllptvm ivasssgsfd fidlsnptlr tqyvhpcqsi 301 kklclspngd vlgileadnh ldtwrrssnn mgmftntpem laypdyfndi tsdgpisvdd 361 etyplssvgm pyyldkllsa wppvvfkseg tipqltgksp lpssgklksn lavissqnek 421 lstqefpllr ydrtkygmrn aipdyvclrd irkqitsgle tsdiqtytsi nkyevppays 481 rlpltsgrfg tdnfdftpfn nteysgldpd vdnhytnaii qlyrfipemf nfvvgclkde 541 nfettlltdl gylfdmmers hgkicsssnf qaslksltdk rqlengepqe hleeyleslc 601 iresiedfns sesikrnmpq kfnrfllsql ikeeaqtvnh nitlnqcfgl eteirtecsc 661 dhydttvkll pslsisgink tvikqlnkks ngqnilpyie yamknvtqkn sicptcgkte 721 titqectvkn lpsvlslels lldtefsnir ssknwltsef ygsiiknkav lrstaselkg 781 tshifkyeln gyvakitdnn netrlvtyvk kynpkencfk wlmfndylvv eiteeealkm 841 typwktpeii iycdaeelrk pffsvdtysi nydilfrdyf angirdtarr eykllthdea 901 pksgtlvaid aefvslqsel ceidhqgirs iirpkrtala risiirgeeg elygvpfvdd 961 yvvntnhied yltrysgilp gdldpekstk rlvrrnvvyr kvwllmqlgc vfvghglnnd 1021 fkhininvpr nqirdtaiyf lqgkrylslr ylayvllgmn iqegnhdsie dahtalilyk 1081 kylhlkekai fekvlnsvye egrahnfkvp etskg // LOCUS NP_011422 917 aa linear PLN 30-JUN-2025 DEFINITION kinetochore-microtubule binding complex subunit SPC105 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011422 VERSION NP_011422.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180958.1 REFERENCE 1 (residues 1 to 917) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 917) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 917) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 917) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 917) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 917) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 917) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 917) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08013. Method: conceptual translation. FEATURES Location/Qualifiers source 1..917 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..917 /product="kinetochore-microtubule binding complex subunit SPC105" /calculated_mol_wt="104695" Region 450..756 /region_name="Spc7" /note="Spc7 kinetochore protein; smart00787" /db_xref="CDD:197874" CDS 1..917 /gene="SPC105" /locus_tag="YGL093W" /coded_by="NM_001180958.1:1..2754" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:19893618|PMID:27170178]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:19893618]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:19893618]" /experiment="EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:19893618]" /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:24402315|PMID:19893618]" /experiment="EXISTENCE:physical interaction:GO:0034501 protein localization to kinetochore [PMID:24402315]" /note="Subunit of a kinetochore-microtubule binding complex; complex bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components; complex also includes Kre28p; modified by sumoylation" /db_xref="GeneID:852787" /db_xref="SGD:S000003061" ORIGIN 1 mnvdersrig grekdagpgk gilkqnqssq mtssflenpg vriptriitk kevldgsntt 61 srintsnlqs mvkrrvsfap dvtlhsftfv peqnneikep rrrktstnsp tkissqeepl 121 vtstqiddar teektaaeed pdtsgmelte pivatpdsnk asqhdptsme mtevfprsir 181 qknpdveges iessqqiddv eavreetmel taihnvhdyd siskdtvege pidlteyesk 241 pyvpnsvsrs tgkssdysve rsndksdlsk senktnssqp meitdifhad pqnpmslhsd 301 nninndgnem eltqiqtnfd rdnhhidesp sekhafssnk rrkldtvsdy aasvttpvke 361 akdtsgednd gdlemmekms pitfsdvdnk igtrsndvft iepgtedtgm qtatddeedg 421 envddngnki vektrlpeid kegqsgialp tqdytlrefi nevgvgfldt kliddldkkv 481 nfplnsfnfv enqridnvfs afyidipile veafrckelw rsineskdkf kdfeaqidks 541 hpplllqeyf ssdekmkqlm rdqlqlvkgy skleaamewy ewrkkqlngl elilaenlnt 601 lkreyeklne evekvnsirg kirklneaik eeirslknlp sdsykptlmn rikieafkqe 661 lmehsislss sndftqemrs lklaiakksn diltlrseva sidkkiekrk lftrfdlpkl 721 rdtlkilesl tgvrflkfsk atlsiaflql ddlrvdinla nfknnplssm kvmndsnndd 781 msyhlftmll knveaehqds mlsnlffamk kwrpllkyik llkllfpvki tqteeeeall 841 qfkdydrrnk taffyvislv sfaqgvfsen gqipmkvhis tqqdyspsre vlsdrithki 901 sgvlpsftks rihleft // LOCUS NP_011423 1317 aa linear PLN 30-JUN-2025 DEFINITION nucleocytoplasmic transporter NUP145 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011423 VERSION NP_011423.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180957.1 REFERENCE 1 (residues 1 to 1317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1317) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08014. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1317 /product="nucleocytoplasmic transporter NUP145" /calculated_mol_wt="145531" Region 34..122 /region_name="Nucleoporin_FG" /note="Nucleoporin FG repeat region; pfam13634" /db_xref="CDD:463941" Region 89..209 /region_name="Nucleoporin_FG" /note="Nucleoporin FG repeat region; pfam13634" /db_xref="CDD:463941" Region 460..605 /region_name="Nucleoporin2" /note="Nucleoporin autopeptidase; pfam04096" /db_xref="CDD:461171" Region 898..1150 /region_name="Nup96" /note="Nuclear protein 96; pfam12110" /db_xref="CDD:463462" CDS 1..1317 /gene="NUP145" /locus_tag="YGL092W" /gene_synonym="RAT10" /coded_by="NM_001180957.1:1..3954" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8044840]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:9305650|PMID:18046406|PMID:11823431]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:20647373]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:20647373]" /experiment="EXISTENCE:genetic interaction:GO:0036228 protein localization to nuclear inner membrane [PMID:21659568]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16418532]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:8524308]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:8044840|PMID:9001245|PMID:9305650|PMID:9133678]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:22331846]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16418532]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:10638763|PMID:16418532|PMID:11862215]" /experiment="EXISTENCE:mutant phenotype:GO:0046822 regulation of nucleocytoplasmic transport [PMID:23499021]" /experiment="EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:9133678|PMID:8195299|PMID:9001245|PMID:9305650]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788]" /note="Essential protein with distinct roles in two nuclear pore subcomplexes; catalyzes its own proteolytic cleavage in vivo to generate a C-terminal fragment that is a structural component of the Nup84p subcomplex (with roles in NPC biogenesis and localization of genes to the nuclear periphery), and an N-terminal fragment that is one of several FG-nucleoporins within the NPC central core directly responsible for nucleocytoplasmic transport; homologous to human NUP98" /db_xref="GeneID:852788" /db_xref="SGD:S000003060" ORIGIN 1 mfnksvnsgf tfgnqntstp tstpaqpsss lqfpqkstgl fgnvnvnant stpspsgglf 61 nansnansis qqpannslfg nkpaqpsggl fgatnnttsk sagslfgnnn atanstgstg 121 lfsgsnnias stqngglfgn snnnnitstt qngglfgkpt ttpagagglf gnssstnstt 181 glfgsnntqs stgifgqkpg asttgglfgn ngasfprsge ttgtmstnpy ginisnvpma 241 vadmprsits slsdvngksd aepkpienrr tysfsssvsg naplplasqs slvsrlstrl 301 katqkstspn eifspsyskp wlngagsapl vddffsskmt slapnensif pqngfnflss 361 qradltelrk lkidsnrsaa kklkllsgtp aitkkhmqde qdssenepia nadsvtnidr 421 kenrdnnldn tylngkeqsn nlnkqdgent lqheksssfg ywcspspeql erlslkqlaa 481 vsnfvigrrg ygcitfqhdv dltaftksfr eelfgkivif rssktvevyp deatkpmigh 541 glnvpaiitl envypvdkkt kkpmkdttkf aefqvfdrkl rsmremnyis ynpfggtwtf 601 kvnhfsiwgl vneedaeide ddlskqedgg eqplrkvrtl aqskpsdkev ilktdgtfgt 661 lsgkddsive ekayepdlsd adfegieasp kldvskdwve qlilagsslr svfatskefd 721 gpcqneidll fsecndeidn aklimkerrf tasytfakfs tgsmlltkdi vgksgvsikr 781 lptelqrkfl fddvyldkei ekvtiearks npypqisess llfkdaldym ektssdynlw 841 klssilfdpv sypyktdndq vkmallkker hcrltswivs qigpeieeki rnssneieqi 901 flylllndvv rasklaiesk nghlsvlisy lgsndprird laelqlqkws tggcsidkni 961 skiykllsgs pfeglfslke lesefswlcl lnltlcygqi deysleslvq shldkfslpy 1021 ddpigvifql yaanentekl ykevrqrtna ldvqfcwyli qtlrfngtrv fsketsdeat 1081 fafaaqlefa qlhghslfvs cflnddkaae dtikrlvmre itllrastnd hilnrlkips 1141 qlifnaqalk dryegnylse vqnlllgssy dlaemaivts lgprlllsnn pvqnnelktl 1201 reilnefpds erdkwsvsin vfevylklvl dnvetqetid slisgmkify dqykhcreva 1261 accnvmsqei vskileknnp sigdskakll elplgqpeka ylrgefaqdl mkctyki // LOCUS NP_011424 328 aa linear PLN 30-JUN-2025 DEFINITION Fe-S cluster-binding ATPase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011424 VERSION NP_011424.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180956.3 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08015. On Jul 30, 2012 this sequence version replaced NP_011424.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..328 /product="Fe-S cluster-binding ATPase" /calculated_mol_wt="35122" Region 70..321 /region_name="ParA" /note="NUBPL iron-transfer P-loop NTPase; pfam10609" /db_xref="CDD:431392" Site order(81..88,220,222,247..248,286..288,291..292) /site_type="active" /db_xref="CDD:349757" Site order(81..83,113..114,116,119..120,163..164,194,196,199, 226,229,287,289..290,292) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:349757" CDS 1..328 /gene="NBP35" /locus_tag="YGL091C" /coded_by="NM_001180956.3:1..987" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15728363|PMID:8921898]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15728363]" /experiment="EXISTENCE:direct assay:GO:0016226 iron-sulfur cluster assembly [PMID:17401378]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:26195633]" /experiment="EXISTENCE:direct assay:GO:0051539 4 iron, 4 sulfur cluster binding [PMID:17401378]" /experiment="EXISTENCE:direct assay:GO:1904564 cytosolic [4Fe-4S] assembly scaffold complex [PMID:26195633]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0005506 iron ion binding [PMID:15728363]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:15728363]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:8921898]" /note="Essential cytoplasmic iron-sulfur cluster binding protein; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases" /db_xref="GeneID:852789" /db_xref="SGD:S000003059" ORIGIN 1 mteilphvnd evlpaeyeln qpepehcpgp esdmagksda cggcankeic eslpkgpdpd 61 iplitdnlsg iehkilvlsg kggvgkstfa amlswalsad edlqvgamdl dicgpslphm 121 lgciketvhe snsgwtpvyv tdnlatmsiq ymlpeddsai iwrgskknll ikkflkdvdw 181 dkldylvidt ppgtsdehis inkymresgi dgalvvttpq evalldvrke idfckkagin 241 ilglvenmsg fvcpnckges qifkattggg ealckelgik flgsvpldpr igkscdmges 301 fldnypdspa ssavlnvvea lrdavgdv // LOCUS NP_011425 421 aa linear PLN 30-JUN-2025 DEFINITION Lif1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011425 VERSION NP_011425.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180955.1 REFERENCE 1 (residues 1 to 421) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 421) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 421) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 421) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08016. Method: conceptual translation. FEATURES Location/Qualifiers source 1..421 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..421 /product="Lif1p" /calculated_mol_wt="48128" Region <208..409 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" CDS 1..421 /gene="LIF1" /locus_tag="YGL090W" /coded_by="NM_001180955.1:1..1266" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10679327]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10679327]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11740566]" /experiment="EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15342630]" /experiment="EXISTENCE:physical interaction:GO:0032807 DNA ligase IV complex [PMID:17567543]" /note="Component of the DNA ligase IV complex; this complex mediates nonhomologous end joining in DNA double-strand break repair; sumoylated by Siz1p and Nfi1p SUMO ligases on Lys301; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein" /db_xref="GeneID:852790" /db_xref="SGD:S000003058" ORIGIN 1 msqltefisc ipvvneeqne ederglckiq iedgamletl denslsglri ekmlvsegtg 61 ifskssfgin dlriftgeni deeskkyvwy ellkmltghk vyiasldekv vftkwtcrmq 121 ddevwkvvme lessaiirki aeltlhpvkk geidlfemad klykdiccvn dsyrnikesd 181 ssnrnrveql arerelldkl letrdertra mmvtllnekk kkirelheil rqnniklsdd 241 dvldsalint evqkpiseln spgkrmkrrk tvvepqnlqk klkdtsrrra nrkisnqsvi 301 kmedddfddf qffglskrpi itakdklsek ydditsfgdd tqsisfesds ssdvqkhlvs 361 ledngiqisa grsdedygdi sgsesetdas agekkssnhs eqsgndrepc lqtesetdie 421 t // LOCUS NP_011426 120 aa linear PLN 30-JUN-2025 DEFINITION Mf(Alpha)2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011426 VERSION NP_011426.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180954.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08017. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..120 /product="Mf(Alpha)2p" /calculated_mol_wt="13140" Region 1..80 /region_name="MF_alpha_N" /note="Mating factor alpha precursor N-terminus; pfam05436" /db_xref="CDD:398869" Region 87..99 /region_name="MF_alpha" /note="Yeast mating factor alpha hormone; pfam04648" /db_xref="CDD:398364" Region 108..120 /region_name="MF_alpha" /note="Yeast mating factor alpha hormone; pfam04648" /db_xref="CDD:398364" CDS 1..120 /gene="MF(ALPHA)2" /locus_tag="YGL089C" /coded_by="NM_001180954.1:1..363" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000772 mating pheromone activity [PMID:6306574]" /experiment="EXISTENCE:direct assay:GO:1903135 cupric ion binding [PMID:27476515]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3887136]" /experiment="EXISTENCE:mutant phenotype:GO:0000772 mating pheromone activity [PMID:3887136]" /note="Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed; binds copper(II) ions" /db_xref="GeneID:852791" /db_xref="SGD:S000003057" ORIGIN 1 mkfistfltf ilaavsvtas sdediaqvpa eaiigyldfg gdhdiaflpf snatasgllf 61 inttiaeaae keqnttlakr eavadawhwl nlrpgqpmyk reanadawhw lqlkpgqpmy // LOCUS NP_001335777 121 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL088W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335777 VERSION NP_001335777.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348836.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80297. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..121 /product="uncharacterized protein" /calculated_mol_wt="14088" CDS 1..121 /locus_tag="YGL088W" /coded_by="NM_001348836.1:1..366" /note="hypothetical protein; conserved across S. cerevisiae strains; partially overlaps snR10, a snoRNA required for preRNA processing" /db_xref="GeneID:852792" /db_xref="SGD:S000003056" ORIGIN 1 mhevtrtyyf flffflsykr qinaafialf dfpllfiyfp flilvlfyns nanltairnt 61 ysissrlnps gafltheecg lvlqyiyywl glenkfidlg cnslsvvcfl adlrvylrvp 121 g // LOCUS NP_011428 137 aa linear PLN 30-JUN-2025 DEFINITION E2 ubiquitin-conjugating protein MMS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011428 VERSION NP_011428.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180952.1 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08018. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..137 /product="E2 ubiquitin-conjugating protein MMS2" /calculated_mol_wt="15414" Region 3..134 /region_name="UEV_UBE2V" /note="ubiquitin E2 variant (UEV) domain of ubiquitin-conjugating enzyme E2 variant 1, 2 and related proteins; cd23807" /db_xref="CDD:467427" CDS 1..137 /gene="MMS2" /locus_tag="YGL087C" /coded_by="NM_001180952.1:1..414" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:10089880]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:32265276]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:10089880]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10880451]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10880451]" /experiment="EXISTENCE:direct assay:GO:0010994 free ubiquitin chain polymerization [PMID:19706603]" /experiment="EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:9576943|PMID:10089880]" /experiment="EXISTENCE:mutant phenotype:GO:0006301 postreplication repair [PMID:10089880|PMID:9576943]" /experiment="EXISTENCE:mutant phenotype:GO:0044395 protein targeting to vacuolar membrane [PMID:32265276]" /experiment="EXISTENCE:physical interaction:GO:0000209 protein polyubiquitination [PMID:10089880]" /experiment="EXISTENCE:physical interaction:GO:0031371 ubiquitin conjugating enzyme complex [PMID:10089880]" /note="Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852793" /db_xref="SGD:S000003055" ORIGIN 1 mskvprnfrl leelekgekg fgpescsygl adsdditmtk wngtilgpph snhenriysl 61 sidcgpnypd sppkvtfisk inlpcvnptt gevqtdfhtl rdwkraytme tllldlrkem 121 atpankklrq pkegetf // LOCUS NP_011429 749 aa linear PLN 30-JUN-2025 DEFINITION coiled-coil domain-containing protein MAD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011429 VERSION NP_011429.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180951.3 REFERENCE 1 (residues 1 to 749) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 749) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 749) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 749) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08019. On Jul 30, 2012 this sequence version replaced NP_011429.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..749 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..749 /product="coiled-coil domain-containing protein MAD1" /calculated_mol_wt="87521" Region 83..747 /region_name="MAD" /note="Mitotic checkpoint protein; pfam05557" /db_xref="CDD:461677" CDS 1..749 /gene="MAD1" /locus_tag="YGL086W" /coded_by="NM_001180951.3:1..2250" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:19139260|PMID:24402315|PMID:27170178]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7593191]" /experiment="EXISTENCE:genetic interaction:GO:0006913 nucleocytoplasmic transport [PMID:12473689]" /experiment="EXISTENCE:genetic interaction:GO:0044774 mitotic DNA integrity checkpoint signaling [PMID:16651657]" /experiment="EXISTENCE:mutant phenotype:GO:0000776 kinetochore [PMID:19139260]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:10704439]" /experiment="EXISTENCE:mutant phenotype:GO:0090268 activation of mitotic cell cycle spindle assembly checkpoint [PMID:15802513]" /experiment="EXISTENCE:mutant phenotype:GO:1901925 negative regulation of protein import into nucleus during spindle assembly checkpoint [PMID:23177738]" /experiment="EXISTENCE:physical interaction:GO:0006913 nucleocytoplasmic transport [PMID:12473689]" /note="Coiled-coil protein involved in spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of anaphase promoting complex activity; forms a complex with Mad2p; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability" /db_xref="GeneID:852794" /db_xref="SGD:S000003054" ORIGIN 1 mdvraalqcf fsalsgrftg kklgleiysi qykmsnsggs spflespggs pdvgstngqs 61 nrqiqalqfk lntlqneyei eklqlqkqtn ilekkykati delekalndt kylyesndkl 121 eqelkslker sansmndkdk cieelrttlq nkdlemetlr qqydsklskv tnqcdhfkle 181 aesshsllmk yekeikrqsv dikdlqhqvm ekddelssvk askminshpn ysteefnelt 241 emnkmiqdqv qytkelelan mqqanelkkl kqsqdtstfw kleneklqnk lsqlhvlesq 301 yenlqlenid lkskltkwei yndsdddddn nvnnndnnnn nkndnnndnn ndtsnnnnin 361 nnnrtknnir nnpeeiirdw kltkkeclil tdmndklrld nnnlkllnde malernqild 421 lnknyenniv nlkrlnhele qqkslsfeec rllreqldgl ysaqnnalle vensethasn 481 knvnedmnnl idtyknkted ltnelkklnd qllsnsndve tqrkkrklts dqiglnysqr 541 lnelqlenvs vsrelskaqt tiqllqekle kltklkekki rilqlrdgpf ikdqfikknk 601 llllekenad llnelkknnp avetvpisvy dslnfelkqf eqevfksnkr fsrlkqvfnn 661 kslefidvvn sllgfklefq qdsrvkifsc fkpekyliad lnentlksnl dadiegwddl 721 mnlwvedrgq lpcflatitl rlweqrqak // LOCUS NP_011430 274 aa linear PLN 30-JUN-2025 DEFINITION Lcl3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011430 VERSION NP_011430.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180950.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08020. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..274 /product="Lcl3p" /calculated_mol_wt="31981" Region 149..261 /region_name="SNase" /note="Staphylococcal nuclease homolog; pfam00565" /db_xref="CDD:395448" Site order(150,156,159,196..197,199) /site_type="other" /note="Catalytic site" /db_xref="CDD:238102" CDS 1..274 /gene="LCL3" /locus_tag="YGL085W" /coded_by="NM_001180950.1:1..825" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="hypothetical protein; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:852795" /db_xref="SGD:S000003053" ORIGIN 1 mregdsnskk sadvavlsii ltgstltliy tykryltqfk rtndiprrif rkhwlygkvt 61 svgdgdnfhf fhmpggirgg wgwlrpvpqm ikndstaekl vgdsrnmrff nfnwithgrs 121 tkskiqkaks qflklnvpyk nrknlptipi rlcgidaper ahfgnpaqpf gnealiwlqn 181 rilgkkvwvk plsidqynrc varvsywdwf ggwkdlslem lkdglavvye gkvntefddr 241 edkyryyefl arsrkkglwi qnkfetpgey kkri // LOCUS NP_011431 560 aa linear PLN 30-JUN-2025 DEFINITION O-acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011431 VERSION NP_011431.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180949.1 REFERENCE 1 (residues 1 to 560) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 560) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 560) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 560) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08021. Method: conceptual translation. FEATURES Location/Qualifiers source 1..560 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..560 /product="O-acyltransferase" /calculated_mol_wt="65209" Region 170..510 /region_name="MBOAT" /note="membrane-bound O-acyltransferase family; pfam03062" /db_xref="CDD:427117" CDS 1..560 /gene="GUP1" /locus_tag="YGL084C" /coded_by="NM_001180949.1:1..1683" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15813700|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15813700]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:16597698]" /experiment="EXISTENCE:mutant phenotype:GO:0008374 O-acyltransferase activity [PMID:18036137|PMID:16597698]" /experiment="EXISTENCE:mutant phenotype:GO:0015793 glycerol transmembrane transport [PMID:10931309]" /experiment="EXISTENCE:mutant phenotype:GO:0019563 glycerol catabolic process [PMID:10747858]" /note="Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; role in misfolded protein quality control; proposed to be involved in glycerol transport; homolog of the mammalian Hedgehog pathway modulator HHATL; GUP1 has a paralog, GUP2, that arose from the whole genome duplication" /db_xref="GeneID:852796" /db_xref="SGD:S000003052" ORIGIN 1 mslisilspl itsegldsri kpspkkdast ttkpslwktt efkfyyiafl vvvplmfyag 61 lqasspenpn yaryerllsq gwlfgrkvdn sdsqyrffrd nfallsvlml vhtsikrivl 121 ystnitklrf dlifgliflv aahgvnsiri lahmlilyai ahvlknfrri atisiwiygi 181 stlfindnfr aypfgnicsf lspldhwyrg iiprwdvffn ftllrvlsyn ldflerwenl 241 qkkkspsyes keaksailln erarltaahp iqdyslmnyi ayvtytplfi agpiitfndy 301 vyqskhtlps infkfifyya vrfviallsm efilhflhvv aisktkawen dtpfqismig 361 lfnlniiwlk llipwrlfrl walldgidtp enmircvdnn ysslafwraw hrsynkwvvr 421 yiyiplggsk nrvltslavf sfvaiwhdie lklllwgwli vlfllpeifa tqifshytda 481 vwyrhvcavg avfniwvmmi anlfgfclgs dgtkkllsdm fctvsgfkfv ilasvslfia 541 vqimfeiree ekrhgiylkc // LOCUS NP_011432 804 aa linear PLN 30-JUN-2025 DEFINITION Scy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011432 VERSION NP_011432.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180948.1 REFERENCE 1 (residues 1 to 804) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 804) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 804) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 804) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 804) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 804) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 804) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 804) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08022. Method: conceptual translation. FEATURES Location/Qualifiers source 1..804 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..804 /product="Scy1p" /calculated_mol_wt="90870" Region 18..326 /region_name="PK_SCY1_like" /note="Pseudokinase domain of Scy1-like proteins; cd14011" /db_xref="CDD:270913" CDS 1..804 /gene="SCY1" /locus_tag="YGL083W" /coded_by="NM_001180948.1:1..2415" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:38126114]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="Putative kinase; suppressor of GTPase mutant; dosage-sensitive modulator of mitochondrial DNA (mtDNA) homeostasis; localizes to the mitochondrial matrix, and to the cytosol and clathrin-coated vesicles in HTP studies; similar to bovine rhodopsin kinase; may have a role in intracellular sterol transport" /db_xref="GeneID:852797" /db_xref="SGD:S000003051" ORIGIN 1 mmfwssktgi tskysfsssp tftaepwsiy tgrpksssss spskvsifmf dkkqfenyll 61 hygiiksksg srdkvliqea yeilrnqann laklkhpnil tliepleehs knfmfvtefv 121 tssletvfre tddeeqnflq ghvkdnivvq rgilqlvnal dfvhnrasfv hlniqpraif 181 inensdwkis glgylvkipp gtntseyflp qydprvppfm hlqlnytape ivfentltfk 241 ndyfslglli yflytgkdlf rsenstseyk leynkfeski stmswdnifs kvpqklrhci 301 pklinrdiys rydnitlild seffqdplvk tlnflddlpt knneekyvfl eglvnllpef 361 ppallqkkfl pillellsqf caekvvsdkc vgksldliik igstlsqlsf qekvypvlls 421 danfpvllkk aticlidnld tlkqkvkrsd flenilkplf nyvlhdsesd itvvcqekll 481 sqiplalevl dfptvkqfll pllsnlftkt tsltvkntcv tcfqimiehk sidsytcset 541 vlplfksmkt rdprilskll klfetvplii tdeivlvdqv lplmwnysma stltksqysg 601 ytkainkmss diqkhhiakl ddkvndiged afhkviepti mkkedpetva aknievaamq 661 pvkkktgssy getlpqsksi lnskplnpkn alatrgfptr ilnsppqtps srtgskvmtk 721 ggsndasstk veeefnefqs fsstgsirqt sapsdvwmns tpsptptsas stnlppgfsi 781 slqpnkrkdg ssdiprsnvy gsli // LOCUS NP_011433 381 aa linear PLN 30-JUN-2025 DEFINITION Miy3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011433 VERSION NP_011433.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180947.3 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08023. On Jul 30, 2012 this sequence version replaced NP_011433.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..381 /product="Miy3p" /calculated_mol_wt="43190" Region 35..147 /region_name="MINDY_DUB" /note="MINDY deubiquitinase; pfam04424" /db_xref="CDD:461303" CDS 1..381 /gene="MIY3" /locus_tag="YGL082W" /coded_by="NM_001180947.3:1..1146" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:39798877|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; MINDY family deubiquitinase that does not appear to contain catalytic activity; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane; not an essential gene; YGL082W has a paralog, YPL191C, that arose from the whole genome duplication; ortholog of human MINDY1/FAM63A" /db_xref="GeneID:852798" /db_xref="SGD:S000003050" ORIGIN 1 mdvtfltknv qingtqfkil lqngqgecal ialanvllis paharyaqei srlvrgketv 61 tlnelvqtla dmgvqnpngt dvdkqqllqi lpqlysglni npefngsfed gvemsifrly 121 nvgivhgwii dgdndpnsye hvskysymga qkvlvqsyei qknnaqfens eqiqsdapyl 181 ksflarsatq lteyglthlr eilversyav lfrndhfctl yknngelftl vtdptyrnrk 241 dinwqslksv ngsqdsyytg nfiptslert ettatgqnes yisnpfsdqn tghvtsnqvn 301 sgasgvqqie ddeelarrlq eqedmraann mqngyanngr nhqrerferp eknskknkfl 361 pfngsnkekk rdklkkncvi m // LOCUS NP_011434 320 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL081W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011434 VERSION NP_011434.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180946.1 REFERENCE 1 (residues 1 to 320) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 320) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 320) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 320) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08024. Method: conceptual translation. FEATURES Location/Qualifiers source 1..320 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..320 /product="uncharacterized protein" /calculated_mol_wt="36259" Region 23..104 /region_name="FHA" /note="FHA domain; pfam00498" /db_xref="CDD:459831" CDS 1..320 /locus_tag="YGL081W" /coded_by="NM_001180946.1:1..963" /note="hypothetical protein; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis" /db_xref="GeneID:852799" /db_xref="SGD:S000003049" ORIGIN 1 mgdirtfvfa iedtettqgl cktigrsssf dqnslckpyn lyfdepelsr qhavlciktp 61 ipkiegvpsi eqlricirdl nnktgtvnlv sdgpndeidl kngdafglia idnhpfrdnh 121 hlaaklifri eleyfdeare ivkctitnvt fgknntvssf pihsatsted sdsswyglse 181 astqtevade chetntiltr ggrfsilslr krgskqdqki csnfdrkihe tssfeeeiev 241 ctdtdtteek eeeeekeegd deegeielei irvkrikgrt kikktltcfs knkkiitpqh 301 snsmwllliv ilifdrllsn // LOCUS NP_011435 130 aa linear PLN 30-JUN-2025 DEFINITION pyruvate transporter MPC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011435 VERSION NP_011435.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180945.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08025. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..130 /product="pyruvate transporter MPC1" /calculated_mol_wt="14864" Region 13..121 /region_name="MPC" /note="Mitochondrial pyruvate carriers; pfam03650" /db_xref="CDD:427425" CDS 1..130 /gene="MPC1" /locus_tag="YGL080W" /gene_synonym="FMP37" /coded_by="NM_001180945.1:1..393" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:22628558|PMID:22628554]" /experiment="EXISTENCE:direct assay:GO:0006850 pyruvate import into mitochondria [PMID:25672363]" /experiment="EXISTENCE:direct assay:GO:0050833 pyruvate transmembrane transporter activity [PMID:25672363]" /experiment="EXISTENCE:mutant phenotype:GO:0006850 pyruvate import into mitochondria [PMID:22628554|PMID:22628558]" /experiment="EXISTENCE:mutant phenotype:GO:0050833 pyruvate transmembrane transporter activity [PMID:22628558|PMID:22628554]" /note="Highly conserved subunit of mitochondrial pyruvate carrier (MPC); MPC is a mitochondrial inner membrane complex that mediates pyruvate uptake comprised of Mpc1p and Mpc2p during fermentative growth, or Mpc1p and Mpc3p during respiratory growth; null mutant displays slow growth that is complemented by expression of the human or mouse ortholog; mutation in human ortholog MPC1 is associated with lactic acidosis and hyperpyruvatemia" /db_xref="GeneID:852800" /db_xref="SGD:S000003048" ORIGIN 1 msqpvqraaa rsflqkyink etlkyiftth fwgpvsnfgi piaaiydlkk dptlisgpmt 61 falvtysgvf mkyalsvspk nyllfgchli netaqlaqgy rflkytyftt deekkaldke 121 wkekektgkq // LOCUS NP_011436 218 aa linear PLN 30-JUN-2025 DEFINITION Kxd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011436 VERSION NP_011436.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180944.1 REFERENCE 1 (residues 1 to 218) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 218) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 218) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 218) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08026. Method: conceptual translation. FEATURES Location/Qualifiers source 1..218 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..218 /product="Kxd1p" /calculated_mol_wt="24311" Region 115..193 /region_name="KxDL" /note="Uncharacterized conserved protein; pfam10241" /db_xref="CDD:463018" CDS 1..218 /gene="KXD1" /locus_tag="YGL079W" /coded_by="NM_001180944.1:1..657" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]" /note="Subunit of the BLOC-1 complex involved in endosomal maturation; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome" /db_xref="GeneID:852801" /db_xref="SGD:S000003047" ORIGIN 1 mvtgiseend deetfsavhs stpsinsqsy aipiteemss sfhdsistts nssgsfdsdg 61 snvsdvveqn emdnesnvde dlfldndipq ssnllptdaq dpgpifdvsr yifdslkqsi 121 dsadfseals lqtktsavin skslelkqyi demksrltql qekfengeat skkikrdlet 181 srknidylna alrvdfpief nqarekiler rlnedhdc // LOCUS NP_011437 523 aa linear PLN 30-JUN-2025 DEFINITION RNA-dependent ATPase DBP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011437 VERSION NP_011437.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180943.3 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08027. On Jul 30, 2012 this sequence version replaced NP_011437.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..523 /product="RNA-dependent ATPase DBP3" /EC_number="3.6.4.13" /calculated_mol_wt="58696" Region 115..470 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..523 /gene="DBP3" /locus_tag="YGL078C" /coded_by="NM_001180943.3:1..1572" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23153376]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9032262]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:23153376|PMID:18975973]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:22083961]" /experiment="EXISTENCE:mutant phenotype:GO:0000464 endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9032262]" /note="RNA-Dependent ATPase, member of DExD/H-box family; involved in cleavage of site A3 within the ITS1 spacer during rRNA processing; not essential for growth, but deletion causes severe slow-growth phenotype" /db_xref="GeneID:852802" /db_xref="SGD:S000003046" ORIGIN 1 mtkeeiadkk rkvvdeevie kkkskkhkkd kkdkkekkdk khkkhkkekk gekevevpek 61 esekkpepts avasefyvqs ealtslpqsd ideyfkenei avedsldlal rpllsfdyls 121 ldssiqaeis kfpkptpiqa vawpyllsgk dvvgvaetgs gktfafgvpa ishlmndqkk 181 rgiqvlvisp trelasqiyd nlivltdkvg mqcccvyggv pkdeqriqlk ksqvvvatpg 241 rlldllqegs vdlsqvnylv ldeadrmlek gfeediknii retdaskrqt lmftatwpke 301 vrelastfmn npikvsignt dqltankrit qivevvdprg kerkllellk kyhsgpkkne 361 kvlifalykk eaarvernlk yngynvaaih gdlsqqqrtq alnefksgks nlllatdvaa 421 rgldipnvkt vinltfpltv edyvhrigrt gragqtgtah tlfteqekhl agglvnvlng 481 anqpvpedli kfgthtkkke hsaygsffkd vdltkkpkki tfd // LOCUS NP_011438 563 aa linear PLN 30-JUN-2025 DEFINITION Hnm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011438 VERSION NP_011438.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180942.1 REFERENCE 1 (residues 1 to 563) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 563) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 563) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 563) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08028. Method: conceptual translation. FEATURES Location/Qualifiers source 1..563 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..563 /product="Hnm1p" /calculated_mol_wt="61925" Region 45..521 /region_name="2A0304" /note="amino acid permease (GABA permease); TIGR00907" /db_xref="CDD:273331" CDS 1..563 /gene="HNM1" /locus_tag="YGL077C" /gene_synonym="CTR1" /coded_by="NM_001180942.1:1..1692" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:24187140]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015220 choline transmembrane transporter activity [PMID:2203793|PMID:3514579]" /experiment="EXISTENCE:mutant phenotype:GO:0015871 choline transport [PMID:2203793]" /experiment="EXISTENCE:mutant phenotype:GO:0031460 glycine betaine transport [PMID:16487344]" /experiment="EXISTENCE:mutant phenotype:GO:0034228 ethanolamine transmembrane transporter activity [PMID:3514579]" /experiment="EXISTENCE:mutant phenotype:GO:0034229 ethanolamine transport [PMID:3514579]" /experiment="EXISTENCE:mutant phenotype:GO:1900749 (R)-carnitine transport [PMID:23755272]" /experiment="EXISTENCE:mutant phenotype:GO:1901235 (R)-carnitine transmembrane transporter activity [PMID:23755272]" /note="Plasma membrane transporter for choline, ethanolamine, and carnitine; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol; human FLVCR2 (MFSD7c), a choline transporter involved in Fowler syndrome, can complement the yeast null mutant" /db_xref="GeneID:852803" /db_xref="SGD:S000003045" ORIGIN 1 msirndnasg gymqpdqssn asmhkrdlrv eeeikplddm dskgavaadg evhlrksfsl 61 wsilgvgfgl tnswfgists mvagissggp mmivygiiiv alisicigts lgelssayph 121 aggqfwwslk lappkykrfa aymcgsfaya gsvftsastt lsvatevvgm yalthpefip 181 krwhifvcfe llhlflmffn cygkslpiis ssslyislls fftititvla cshgkfndak 241 fvfatfnnet gwknggiafi vglinpawsf scldcathma fevekpervi piaimgtvai 301 gfvtsfcyvi amffsiqdld avlssttgap ildiynqalg nksgaiflgc lilftsfgcv 361 iachtwqarl cwsfardngl plsrlwsqvn phtgvplnah lmscawitli gllylassta 421 fqslitgcia flllsyiipv icllakkrni ahgpfwlgkf gffsnivllg wtvfsvvffs 481 fppvlpvtkd nmnyvcvviv gytaysilyw kykgkkefha leeseneqae ysnnfdtied 541 srefsvaasd velenehvpw gkk // LOCUS NP_011439 244 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL30 RPL7A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011439 VERSION NP_011439.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180941.1 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08029. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..244 /product="60S ribosomal protein uL30 RPL7A" /calculated_mol_wt="27507" Region 10..244 /region_name="uL30_euk" /note="60S ribosomal protein uL30, eukaryotic form; TIGR01310" /db_xref="CDD:273548" CDS 1..244 /gene="RPL7A" /locus_tag="YGL076C" /coded_by="NM_001180941.1:1..735" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19466602]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:23945946]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22893726]" /note="Ribosomal 60S subunit protein L7A; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7A has a paralog, RPL7B, that arose from the whole genome duplication" /db_xref="GeneID:852804" /db_xref="SGD:S000003044" ORIGIN 1 maaekiltpe sqlkkskaqq ktaeqvaaer aarkaankek raiilernaa yqkeyetaer 61 niiqakrdak aagsyyveaq hklvfvvrik ginkippkpr kvlqllrltr insgtfvkvt 121 katlellkli epyvaygyps ystirqlvyk rgfgkinkqr vplsdnaiie anlgkygils 181 iddliheiit vgphfkqann flwpfklsnp sggwgvprkf khfiqggsfg nreefinklv 241 ksmn // LOCUS NP_011440 387 aa linear PLN 30-JUN-2025 DEFINITION Mps2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011440 VERSION NP_011440.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180940.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08030. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..387 /product="Mps2p" /calculated_mol_wt="44454" Region 10..386 /region_name="MPS2" /note="Monopolar spindle protein 2; pfam17060" /db_xref="CDD:407228" CDS 1..387 /gene="MPS2" /locus_tag="YGL075C" /gene_synonym="MMC1" /coded_by="NM_001180940.1:1..1164" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:32967926]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:10397772]" /experiment="EXISTENCE:direct assay:GO:0005640 nuclear outer membrane [PMID:32059771]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10397772]" /experiment="EXISTENCE:direct assay:GO:0034993 meiotic nuclear membrane microtubule tethering complex [PMID:32967926]" /experiment="EXISTENCE:direct assay:GO:0044821 meiotic telomere tethering at nuclear periphery [PMID:32967926]" /experiment="EXISTENCE:direct assay:GO:0140444 cytoskeleton-nuclear membrane anchor activity [PMID:32967926]" /experiment="EXISTENCE:genetic interaction:GO:0030474 spindle pole body duplication [PMID:10654940]" /experiment="EXISTENCE:mutant phenotype:GO:0000741 karyogamy [PMID:16923827]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:1869587|PMID:10654940|PMID:16923827]" /experiment="EXISTENCE:mutant phenotype:GO:0034993 meiotic nuclear membrane microtubule tethering complex [PMID:32059771]" /experiment="EXISTENCE:mutant phenotype:GO:0071988 protein localization to spindle pole body [PMID:16923827]" /experiment="EXISTENCE:mutant phenotype:GO:0140444 cytoskeleton-nuclear membrane anchor activity [PMID:32059771]" /note="Essential membrane protein localized at nuclear envelope and SPBs; required for insertion of the newly duplicated spindle pole body into the nuclear envelope; potentially phosphorylated by Cdc28p; MPS2 has a paralog, CSM4, that arose from the whole genome duplication" /db_xref="GeneID:852805" /db_xref="SGD:S000003043" ORIGIN 1 msngafdaif eyawgqidkp isgdfiygkd lpklieiien ifqkaqksgs yelrlplfse 61 inkdlfrtfs ntktffkihk eefddiffnl vnhplreile nafigvdsip sdfivsmnln 121 spskflvenk nkntegagis tprkkltesp ikllsrnnig kalevqveel kreltakqsl 181 lqenerqvse lkirletyqe kyasiqqrfs dlqkarqved nqnssrtsdp gsplvtgidq 241 kaileefrrr lqrqtdtisf lkdqirrerg lncsndkvsh skrkhattdg dgtfknfisa 301 vpsniwvkat iriivcfall agvlpyirky vyahdtpsqn srlqlswwen sgilskivwf 361 fedqtdlete yrsnanvdda ysrvfgi // LOCUS NP_011442 833 aa linear PLN 30-JUN-2025 DEFINITION stress-responsive transcription factor HSF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011442 VERSION NP_011442.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180938.3 REFERENCE 1 (residues 1 to 833) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 833) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 833) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 833) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08031. On Jul 30, 2012 this sequence version replaced NP_011442.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..833 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..833 /product="stress-responsive transcription factor HSF1" /calculated_mol_wt="93151" Region 165..453 /region_name="HSF1" /note="Heat shock transcription factor [Transcription]; COG5169" /db_xref="CDD:227497" CDS 1..833 /gene="HSF1" /locus_tag="YGL073W" /gene_synonym="EXA3; MAS3" /coded_by="NM_001180938.3:1..2502" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:3044612]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12821147]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:3044612]" /experiment="EXISTENCE:direct assay:GO:0043555 regulation of translation in response to stress [PMID:31124783]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:8985158|PMID:3044612|PMID:2017170]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:9296388]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27320198|PMID:9296388]" /experiment="EXISTENCE:mutant phenotype:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:18270585]" /note="Trimeric heat shock transcription factor; forms condensate with Mediator and RNA Pol II upon heat shock; activates multiple genes in response to diverse stresses and transient intracellular acidification; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; monitors translational status through RQC (Ribosomal Quality Control)-mediated translation-stress signal; human homolog HSF1 with linker region mutations can complement yeast hsf1 mutant" /db_xref="GeneID:852806" /db_xref="SGD:S000003041" ORIGIN 1 mnnaantgtt nesnvsdapr ieplpslndd diekilqpnd ifttdrtdas ttsstaiedi 61 inpsldpqsa aspvpsssff hdsrkpstst hlvrrgtplg iyqtnlyghn srentnpnst 121 llsskllahp pvpygqnpdl lqhavyraqp ssgttnaqpr qttrryqshk srpafvnklw 181 smlnddsntk liqwaedgks fivtnreefv hqilpkyfkh snfasfvrql nmygwhkvqd 241 vksgsiqsss ddkwqfenen firgredlle kiirqkgssn nhnspsgngn pangsnipld 301 naagsnnsnn nisssnsffn nghllqgktl rlmneanlgd kndvtailge leqikynqia 361 iskdllrink dnellwqenm marerhrtqq qalekmfrfl tsivphldpk mimdglgdpk 421 vnneklnsan niglnrdntg tidelksnds finddrnsft nattnarnnm spnnddnsid 481 tastnttnrk knideniknn ndiindiifn tnlannlsny nsnnnagspi rpykqryllk 541 nransstsse npsltpfdie snndrkisei pfddeeeeet dfrpftsrdp nnqtsentfd 601 pnrftmlsdd dlkkdshtnd nkhnesdlfw dnvhrnideq darlqnlenm vhilspgypn 661 ksfnnktsst ntnsnmesav nvnspgfnlq dyltgesnsp nsvhsvpsng sgstplpmpn 721 dndtehasts vnqgengsgl tpfltvddht lndnntsegs trvspdikfs atentkvsdn 781 lpsfndhsys tqadtapena kkrfveeipe paiveiqdpt eyndhrlpkr akk // LOCUS NP_011444 690 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcription factor AFT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011444 VERSION NP_011444.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180936.1 REFERENCE 1 (residues 1 to 690) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 690) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 690) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 690) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08032. Method: conceptual translation. FEATURES Location/Qualifiers source 1..690 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..690 /product="DNA-binding transcription factor AFT1" /calculated_mol_wt="77552" Region 108..243 /region_name="AFT" /note="Transcription factor AFT; pfam08731" /db_xref="CDD:400877" CDS 1..690 /gene="AFT1" /locus_tag="YGL071W" /gene_synonym="RCS1" /coded_by="NM_001180936.1:1..2073" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:27402848|PMID:8670839]" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:8670839]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:16911514|PMID:11877447]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:11877447|PMID:16911514]" /experiment="EXISTENCE:direct assay:GO:0043515 kinetochore binding [PMID:16172405]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14739928]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27402848]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16172405]" /experiment="EXISTENCE:mutant phenotype:GO:0010106 cellular response to iron ion starvation [PMID:12095998|PMID:7720713]" /experiment="EXISTENCE:mutant phenotype:GO:0032048 cardiolipin metabolic process [PMID:27402848]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:22157760]" /experiment="EXISTENCE:mutant phenotype:GO:0034758 positive regulation of iron ion transport [PMID:7720713]" /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:22157760]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7720713|PMID:12095998]" /note="Transcription factor involved in iron utilization and homeostasis; binds consensus site PyPuCACCCPu and activates transcription in response to changes in iron availability; in iron-replete conditions localization is regulated by Grx3p, Grx4p, and Fra2p, and promoter binding is negatively regulated via Grx3p-Grx4p binding; AFT1 has a paralog, AFT2, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:852809" /db_xref="SGD:S000003039" ORIGIN 1 megfnpadie haspinssds hsssfvyalp ksaseyvvnh negrasasgn paavpspimt 61 lnlksthsln idqhvhtsts ptetighihh veklnqnnli hldpvpnfed ksdikpwlqk 121 ifypqgielv iersdafkvv fkckaakrgr narrkrkdkp kgqdhedeks kinddeleya 181 spsnatvtng pqtspdqtss ikpkkkrcvs rfnncpfrvr atyslkrkrw sivvmdnnhs 241 hqlkfnpdse eykkfkeklr kdndvdaikk fdeleyrtla nlpiptatip cdcgltneiq 301 sfnvvlptns nvtssassst vssisldssn askrpclpsv nntgsintnn vrkpksqckn 361 kdtllkrttm qnflttksrl rktgtptssq hsstafsgyi ddpfnlneil plpasdfkln 421 tvtnlneidf tniftksphp hsgsthprqv fdqlddcssi lfsplttntn nefegesddf 481 vhspylnsea dfsqilssap pvhhdpneth qenqdiidrf anssqehney ilqylthsda 541 anhnnigvpn nnshslntqh nvsdlgnsll rqealvgsss tkifdelkfv qngphgsqhp 601 idfqhvdhrh lssnepqvrs hqygpqqqpp qqlqyhqnqp hdghnheqhq tvqkdmqthe 661 sleimgntll eefkdikmvn gelkyvkped // LOCUS NP_011445 122 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase II core subunit RPB9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011445 VERSION NP_011445.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180935.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08033. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..122 /product="DNA-directed RNA polymerase II core subunit RPB9" /calculated_mol_wt="14157" Region 5..58 /region_name="RPOL9" /note="RNA polymerase subunit 9; smart00661" /db_xref="CDD:197822" Region 64..111 /region_name="Zn-ribbon_RPB9" /note="C-terminal zinc ribbon domain of RPB9 subunit of RNA polymerase II; cd10508" /db_xref="CDD:259793" Site order(64,66..67,69,86..87,89,97..99) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:259793" Site order(75,78,103,106) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:259793" CDS 1..122 /gene="RPB9" /locus_tag="YGL070C" /gene_synonym="SSU73" /coded_by="NM_001180935.1:1..369" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1331084|PMID:2183013|PMID:2186966]" /experiment="EXISTENCE:genetic interaction:GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [PMID:17535246]" /experiment="EXISTENCE:genetic interaction:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17030604]" /experiment="EXISTENCE:mutant phenotype:GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [PMID:16492753]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:17179178]" /experiment="EXISTENCE:mutant phenotype:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:7800482]" /note="RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription; positively regulates ATG1 transcription as a key regulator of autophagy" /db_xref="GeneID:852810" /db_xref="SGD:S000003038" ORIGIN 1 mttfrfcrdc nnmlypredk ennrllfecr tcsyveeags plvyrhelit nigetagvvq 61 digsdptlpr sdrecpkchs renvffqsqq rrkdtsmvlf fvclscshif tsdqknkrtq 121 fs // LOCUS NP_011447 194 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL12m MNP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011447 VERSION NP_011447.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180933.1 REFERENCE 1 (residues 1 to 194) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 194) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 194) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 194) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08034. Method: conceptual translation. FEATURES Location/Qualifiers source 1..194 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..194 /product="mitochondrial 54S ribosomal protein bL12m MNP1" /calculated_mol_wt="20519" Region 52..193 /region_name="Ribosomal_L7_L12" /note="Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; cd00387" /db_xref="CDD:100102" Site order(52,65..67,70..71,74,77,107,110..111,113..115, 125..126,148,150..151,153,155..156,170..171,173,176) /site_type="other" /note="core dimer interface [polypeptide binding]" /db_xref="CDD:100102" Site order(55,58,62,75,80) /site_type="other" /note="peripheral dimer interface [polypeptide binding]" /db_xref="CDD:100102" Site order(69,72..73,77,80) /site_type="other" /note="L10 interface [polypeptide binding]" /db_xref="CDD:100102" Site order(139..140,143..144,147,154..155,158) /site_type="other" /note="L11 interface [polypeptide binding]" /db_xref="CDD:100102" Site order(140,144,147,154..155,158) /site_type="other" /note="putative EF-Tu interaction site [polypeptide binding]" /db_xref="CDD:100102" Site order(140,143..144,147) /site_type="other" /note="putative EF-G interaction site [polypeptide binding]" /db_xref="CDD:100102" CDS 1..194 /gene="MNP1" /locus_tag="YGL068W" /gene_synonym="bL12m" /coded_by="NM_001180933.1:1..585" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:24675956]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:24675956]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:24675956]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15221522]" /note="Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L7/L12 and human MRPL7 ribosomal proteins; associates with the mitochondrial nucleoid; required for normal respiratory growth" /db_xref="GeneID:852811" /db_xref="SGD:S000003036" ORIGIN 1 mslrilakrs ssiwmktrvt palispitit trfnstttta pshkddvrpv dpkiskivqd 61 isqltllets slinelktvl nipeismpmg gfmagaagag agnvpsstge agsgaeeeak 121 peaktvftvk ldsfdtktka kvikevkgll glslveakkf veaapkvlke nvakddaeki 181 kktledlgak vsle // LOCUS NP_011448 384 aa linear PLN 30-JUN-2025 DEFINITION NAD(+) diphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011448 VERSION NP_011448.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180932.3 REFERENCE 1 (residues 1 to 384) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 384) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 384) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 384) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08035. On Jul 30, 2012 this sequence version replaced NP_011448.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..384 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..384 /product="NAD(+) diphosphatase" /EC_number="3.6.1.22" /calculated_mol_wt="43386" Region 1..368 /region_name="NPY1" /note="NADH pyrophosphatase NudC, Nudix superfamily [Nucleotide transport and metabolism]; COG2816" /db_xref="CDD:442065" CDS 1..384 /gene="NPY1" /locus_tag="YGL067W" /coded_by="NM_001180932.3:1..1155" /experiment="EXISTENCE:direct assay:GO:0000210 NAD+ diphosphatase activity [PMID:11361135]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:11361135]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0019674 NAD+ metabolic process [PMID:11361135]" /experiment="EXISTENCE:mutant phenotype:GO:0110154 RNA decapping [PMID:34074215]" /experiment="EXISTENCE:mutant phenotype:GO:0110155 NAD-cap decapping [PMID:33139726]" /note="NADH diphosphatase (pyrophosphatase); hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes; enzymatic component of one of several partly redundant surveillance pathways involved in decapping of non-canonical nicotinamide adenine dinucleotide (NAD) capped nuclear mRNAs (NAD-RNAs); also possesses deCoAping activity involved in the decapping of non-canonical dephospho-CoA capped RNA (dpCoA-RNA); nudix hydrolase family member" /db_xref="GeneID:852813" /db_xref="SGD:S000003035" ORIGIN 1 mstavtffgq hvlnrvsflr cskefikksl nhdstvfipf iegealispe ngdlvqlsns 61 vksyknilsa ivplyttlln ttrsrsdesg invtflglle gtdsafnfew snisykgtpy 121 fgldirvtes tlfkkvdfep ifsypkvtrd hifkqtneda slysqgkmyl dwlakykfcp 181 gcgsplfpve agtklqcsne nrnvycnvrd arinnvcfpr tdptviialt nsdyskccla 241 rskkrygdfv lystiagfme psetieeaci reiweetgis cknidivrsq pwpypcslmi 301 gclgivqfns knevinlnhd delldaqwfd tteiiqaldk yaggyrvpfk ndinlpgstt 361 iafqlinhvc enyknlrkts sshl // LOCUS NP_011449 657 aa linear PLN 30-JUN-2025 DEFINITION deubiquitination module subunit SGF73 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011449 VERSION NP_011449.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180931.1 REFERENCE 1 (residues 1 to 657) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 657) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 657) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 657) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08036. Method: conceptual translation. FEATURES Location/Qualifiers source 1..657 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..657 /product="deubiquitination module subunit SGF73" /calculated_mol_wt="72747" Region 59..100 /region_name="zf_C2H2_13" /note="Zinc finger domain; pfam18508" /db_xref="CDD:436552" Region 219..279 /region_name="SCA7" /note="zinc-binding domain; pfam08313" /db_xref="CDD:462422" CDS 1..657 /gene="SGF73" /locus_tag="YGL066W" /gene_synonym="SCA7" /coded_by="NM_001180931.1:1..1974" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:12052880|PMID:17090597]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:18488019]" /experiment="EXISTENCE:direct assay:GO:0046822 regulation of nucleocytoplasmic transport [PMID:31165730]" /experiment="EXISTENCE:direct assay:GO:0071819 DUBm complex [PMID:20395473]" /experiment="EXISTENCE:direct assay:GO:1905634 regulation of protein localization to chromatin [PMID:31165730]" /experiment="EXISTENCE:genetic interaction:GO:0005198 structural molecule activity [PMID:15932941]" /experiment="EXISTENCE:mutant phenotype:GO:0004402 histone acetyltransferase activity [PMID:15932941]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:15932941]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:17090597|PMID:15932941]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:18488019]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:20434206]" /experiment="EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:17090597]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:19226466]" /experiment="EXISTENCE:physical interaction:GO:0000124 SAGA complex [PMID:15932941]" /experiment="EXISTENCE:physical interaction:GO:0046695 SLIK (SAGA-like) complex [PMID:15932941]" /note="Subunit of DUBm module of SAGA and SLIK; has roles in anchoring deubiquitination module (DUBm) into SAGA and SLIK complexes, maintaining organization and ubiquitin-binding conformation of Ubp8p, thereby contributing to overall DUBm activity; involved in preinitiation complex assembly at promoters; relocalizes to cytosol under hypoxia; human homolog ATXN7 implicated in spinocerebellar ataxia, and can complement yeast null mutant" /db_xref="GeneID:852814" /db_xref="SGD:S000003034" ORIGIN 1 mrsgdaeikg ikpkvieeys lsqgsgpsnd swkslmssak dtplqydhmn reslkkyfnp 61 naqliedpld kpiqyrvcek cgkplaltai vdhlenhcag asgksstdpr destretirn 121 gvestgrnnn dddnsndnnn dddddddndd neddddaddd ddnsnganyk kndssfnplk 181 rstsmesant pnmdtkrskt gtpqtfsssi kkqkkvkqrn ptekhlidfn kqcgvelpeg 241 gycarsltck shsmgakrav sgrskpydvl ladyhrehqt kigaaaekra kqqelqklqk 301 qiqkeqkkht qqqkqgqrsk qrnvnggksa knggkstvhn gnnineighv nltpeeettq 361 vlngvsrsfp lplestvlss vryrtkyfrm remfassfsv kpgytspgyg aihsrvgcld 421 ldrttdykfr vrtpqpinhl tnqnlnpkqi qrlqqqralq aqllsqqqqq qqqqqqhhsp 481 qaqaqastqq ptqgmvpnhf pggatnssfn anvsskqiqq qqqqqqhksq dtgltpleiq 541 sqqqklrqqq lqqqkfeaaa sylanatklm qesnqdshls gthnnnsskn gnnnlmtmka 601 sisspntsvn siqsppsvns vngsgqgvst ginvsgnngr ievgignsvn pyngrin // LOCUS NP_011450 503 aa linear PLN 30-JUN-2025 DEFINITION GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011450 VERSION NP_011450.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180930.1 REFERENCE 1 (residues 1 to 503) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 503) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 503) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 503) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08037. Method: conceptual translation. FEATURES Location/Qualifiers source 1..503 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..503 /product="GDP-Man:Man(1)GlcNAc(2)-PP-dolichol alpha-1,3-mannosyltransferase" /EC_number="2.4.1.132" /EC_number="2.4.1.257" /calculated_mol_wt="57916" Region 7..426 /region_name="GT4_ALG2-like" /note="alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; cd03805" /db_xref="CDD:340834" Site order(20,223..225,318,340) /site_type="other" /note="putative ADP-binding pocket [chemical binding]" /db_xref="CDD:340834" CDS 1..503 /gene="ALG2" /locus_tag="YGL065C" /coded_by="NM_001180930.1:1..1512" /experiment="EXISTENCE:direct assay:GO:0004378 GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity [PMID:16878994]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:16878994]" /experiment="EXISTENCE:direct assay:GO:0033164 initiation-specific glycolipid 1,6-alpha-mannosyltransferase activity [PMID:16878994]" /note="Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in N-linked glycosylation pathway; mutants exhibit temperature-sensitive growth and abnormal accumulation of lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; mutations of human ALG2 cause congenital myasthenic syndrome; human ALG2 complements temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement" /db_xref="GeneID:852815" /db_xref="SGD:S000003033" ORIGIN 1 miekdkrtia fihpdlgigg aerlvvdaal glqqqghsvi iytshcdksh cfeevkngql 61 kvevygdflp tnflgrffiv fatirqlylv iqlilqkkvn ayqliiidql stcipllhif 121 ssatlmfych fpdqllaqra gllkkiyrlp fdlieqfsvs aadtvvvnsn ftkntfhqtf 181 kylsndpdvi ypcvdlstie iedidkkffk tvfnegdrfy lsinrfekkk dvalaikafa 241 lsedqindnv klvicggyde rvaenveylk elqsladeye lshttiyyqe ikrvsdlesf 301 ktnnskiifl tsissslkel llertemlly tpayehfgiv pleamklgkp vlavnnggpl 361 etiksyvage nessatgwlk pavpiqwata idesrkilqn gsvnferngp lrvkkyfsre 421 amtqsfeenv ekviwkekky ypweifgisf snfilhmafi kilpnnpwpf lfmatfmvly 481 fknylwgiyw afvfalsypy eei // LOCUS NP_011451 561 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011451 VERSION NP_011451.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180929.1 REFERENCE 1 (residues 1 to 561) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 561) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 561) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 561) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08038. Method: conceptual translation. FEATURES Location/Qualifiers source 1..561 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..561 /product="ATP-dependent RNA helicase" /EC_number="3.6.4.13" /calculated_mol_wt="62927" Region 100..346 /region_name="DEADc_MRH4" /note="DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; cd17965" /db_xref="CDD:350723" Site order(133..134,136..138,141,165..172) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350723" Site 287..290 /site_type="other" /note="DEAD box helicase motif" /db_xref="CDD:350723" Region 384..538 /region_name="SF2_C_DEAD" /note="C-terminal helicase domain of the DEAD box helicases; cd18787" /db_xref="CDD:350174" Site order(498,500,525,528..529) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350174" CDS 1..561 /gene="MRH4" /locus_tag="YGL064C" /coded_by="NM_001180929.1:1..1686" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:12702275|PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:24206665]" /experiment="EXISTENCE:direct assay:GO:1990400 mitochondrial ribosomal large subunit rRNA binding [PMID:24206665]" /experiment="EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:24206665]" /experiment="EXISTENCE:mutant phenotype:GO:0016070 RNA metabolic process [PMID:12702275]" /experiment="EXISTENCE:mutant phenotype:GO:1902775 mitochondrial large ribosomal subunit assembly [PMID:31053642|PMID:24206665]" /note="Mitochondrial ATP-dependent RNA helicase of the DEAD-box family; required for assembly of the large subunit of mitochondrial ribosomes; binds to the large subunit rRNA, 21S_rRNA; localizes to the matrix face of the mitochondrial inner membrane and associates with the large subunit precursor and with mature ribosomes" /db_xref="GeneID:852816" /db_xref="SGD:S000003032" ORIGIN 1 mslffkpvis pqwsfpvllk igvrsyaggp rtkhkgnspl asvptgssnk nrkqkakgkk 61 gnkkndpdqa fnfgeygglk kdvemnmdst nkliqkisnf dqllilppvr davkeiiske 121 slklqdsrkk tseniipspi qtvaikrisk nlmdpklqih aiaaetgsgk tmayliplid 181 ylkrqeletp elwetlrknv lirsiilvpt helvdqvyet vsktktllgl nsfkwdkats 241 yrdllenikn ridilvttpg kllnlfsirm itrpdkvlsk vgfvvldead tlldrswlee 301 thsaikripn inhlifcsat ipqefnktmq rlfptvvpim tprlhklpfa ldfkvinsal 361 spfkgskika laqtlyaisn ddtepgfekr ciifvnekkn vpeivnllnk kfghnaiglt 421 gedtfeerse kimpflsppr plsevvaqst spptslkkfe ipdsnivigk lkntnsngta 481 psnkslhvlv ttdlmargln fkgvrnvvly dvpktsidli hrvgrtarmk qggrvfmltd 541 sktkswakal pkiikkhqrl s // LOCUS NP_011452 370 aa linear PLN 30-JUN-2025 DEFINITION pseudouridine synthase PUS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011452 VERSION NP_011452.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180928.4 REFERENCE 1 (residues 1 to 370) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 370) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 370) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 370) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08039. On Jul 30, 2012 this sequence version replaced NP_011452.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..370 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..370 /product="pseudouridine synthase PUS2" /EC_number="5.4.99.44" /calculated_mol_wt="41760" Region 1..308 /region_name="PseudoU_synth_PUS1_PUS2" /note="Pseudouridine synthase, PUS1/ PUS2 like; cd02568" /db_xref="CDD:211335" Site order(53..56,262) /site_type="active" /note="probable active site [active]" /db_xref="CDD:211335" CDS 1..370 /gene="PUS2" /locus_tag="YGL063W" /coded_by="NM_001180928.4:1..1113" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17684231]" /experiment="EXISTENCE:genetic interaction:GO:0009982 pseudouridine synthase activity [PMID:17684231]" /experiment="EXISTENCE:genetic interaction:GO:0031119 tRNA pseudouridine synthesis [PMID:17684231]" /experiment="EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:17684231]" /experiment="EXISTENCE:mutant phenotype:GO:0031119 tRNA pseudouridine synthesis [PMID:17684231]" /experiment="EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25192136]" /note="Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification; mutation also affects pseudouridylation of some nuclear-encoded mRNAs; PUS2 has a paralog, PUS1, that arose from the whole genome duplication" /db_xref="GeneID:852817" /db_xref="SGD:S000003031" ORIGIN 1 mllgycgsgy ygmqynpphk tiegeiltkl fdvgaiseen slapkknsfm aaartdkgvh 61 amlnllslki tlredtvakl naalppeirv wgiqpvnkkf narsacdsrw yqylipefil 121 igpprssllh rnvggcyred gsqevwdtfl eqtrgrfsgd elcrlqdtaq klsesdplvq 181 dyvgllsgtl sgyclspskl dafeaamqey vgthnfhnft tgklwgdpsa qrhikkvvvs 241 qaspgwicvr ihgqsfmlhq irrmvalavl aarcqlppni vrnyfnagpr kyiprapaqg 301 lllegpvfdg yntklrnlly ceirpdditl ermcrfrerq ictaiaheet qrhvfchfvr 361 qmnrlatpli // LOCUS NP_011453 1178 aa linear PLN 30-JUN-2025 DEFINITION pyruvate carboxylase 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011453 VERSION NP_011453.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180927.1 REFERENCE 1 (residues 1 to 1178) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1178) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1178) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1178) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08040. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1178 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1178 /product="pyruvate carboxylase 1" /EC_number="6.4.1.1" /calculated_mol_wt="129969" Region 21..1169 /region_name="pyruv_carbox" /note="pyruvate carboxylase; TIGR01235" /db_xref="CDD:130302" CDS 1..1178 /gene="PYC1" /locus_tag="YGL062W" /coded_by="NM_001180927.1:1..3537" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:2665820|PMID:196563]" /experiment="EXISTENCE:mutant phenotype:GO:0004736 pyruvate carboxylase activity [PMID:2039506]" /experiment="EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:8185321]" /note="Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication" /db_xref="GeneID:852818" /db_xref="SGD:S000003030" ORIGIN 1 msqrkfaglr dnfnllgekn kilvanrgei pirifrtahe lsmqtvaiys hedrlsthkq 61 kadeayvige vgqytpvgay laideiisia qkhqvdfihp gygflsense fadkvvkagi 121 twigppaevi dsvgdkvsar nlaakanvpt vpgtpgpiet veealdfvne ygypviikaa 181 fggggrgmrv vregddvada fqratseart afgngtcfve rfldkpkhie vqlladnhgn 241 vvhlferdcs vqrrhqkvve vapaktlpre vrdailtdav klakecgyrn agtaeflvdn 301 qnrhyfiein priqvehtit eeitgidiva aqiqiaagas lpqlglfqdk ittrgfaiqc 361 rittedpakn fqpdtgriev yrsaggngvr ldggnayagt iisphydsml vkcscsgsty 421 eivrrkmira liefrirgvk tnipflltll tnpvfiegty wttfiddtpq lfqmvssqnr 481 aqkllhylad vavngssikg qiglpklksn psvphlhdaq gnvinvtksa ppsgwrqvll 541 ekgpaefarq vrqfngtllm dttwrdahqs llatrvrthd latiapttah alagrfalec 601 wggatfdvam rflhedpwer lrklrslvpn ipfqmllrga ngvaysslpd naidhfvkqa 661 kdngvdifrv fdalndleql kvgvdavkka ggvveatvcf sgdmlqpgkk ynldyyleia 721 ekivqmgthi lgikdmagtm kpaaakllig slrakypdlp ihvhthdsag tavasmtaca 781 lagadvvdva insmsgltsq psinallasl egnidtginv ehvreldayw aemrllyscf 841 eadlkgpdpe vyqheipggq ltnllfqaqq lglgeqwaet krayreanyl lgdivkvtpt 901 skvvgdlaqf mvsnkltsdd vrrlansldf pdsvmdffeg ligqpyggfp epfrsdvlrn 961 krrkltcrpg lelepfdlek iredlqnrfg dvdecdvasy nmyprvyedf qkmretygdl 1021 svlptrsfls pletdeeiev vieqgktlii klqavgdlnk ktgerevyfd lngemrkirv 1081 adrsqkvetv tkskadmhdp lhigapmagv ivevkvhkgs likkgqpvav lsamkmemii 1141 sspsdgqvke vfvsdgenvd ssdllvlled qvpvetka // LOCUS NP_011454 247 aa linear PLN 30-JUN-2025 DEFINITION Duo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011454 VERSION NP_011454.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180926.1 REFERENCE 1 (residues 1 to 247) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 247) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 247) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 247) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08041. Method: conceptual translation. FEATURES Location/Qualifiers source 1..247 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..247 /product="Duo1p" /calculated_mol_wt="27342" Region 63..135 /region_name="DASH_Duo1" /note="DASH complex subunit Duo1; pfam08651" /db_xref="CDD:462549" CDS 1..247 /gene="DUO1" /locus_tag="YGL061C" /coded_by="NM_001180926.1:1..744" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15640796|PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]" /experiment="EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479465|PMID:20479468]" /note="Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Dam1p and Pse1p to connect the DASH complex with microtubules (MT); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" /db_xref="GeneID:852819" /db_xref="SGD:S000003029" ORIGIN 1 mseqsqldds tidklipqif nemrsnlnnt tnkfpkstgg gasdnisans nsirsfnsit 61 tqsllkeses ldkitamikn vtaalknnlp vyvnqvhevc kstnsildsw inihsqagyi 121 hklmsdqtyl klindrlhne nvntndedgs tlhnvialkk keildlrqkl enrkgekdaa 181 pakppnqgln prygvqsgrr pvpsagisnn grvrkthvpa skrpsgiprv tnrwtkptas 241 ssrkmfr // LOCUS NP_011455 641 aa linear PLN 30-JUN-2025 DEFINITION Ybp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011455 VERSION NP_011455.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180925.1 REFERENCE 1 (residues 1 to 641) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 641) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 641) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 641) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 641) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 641) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 641) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 641) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08042. Method: conceptual translation. FEATURES Location/Qualifiers source 1..641 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..641 /product="Ybp2p" /calculated_mol_wt="72971" Region 1..633 /region_name="Kinetochor_Ybp2" /note="Uncharacterized protein family, YAP/Alf4/glomulin; pfam08568" /db_xref="CDD:400745" CDS 1..641 /gene="YBP2" /locus_tag="YGL060W" /gene_synonym="YBH1" /coded_by="NM_001180925.1:1..1926" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:18286174]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0007052 mitotic spindle organization [PMID:18286174]" /note="Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication" /db_xref="GeneID:852820" /db_xref="SGD:S000003028" ORIGIN 1 myneqvnsgk sikekeryld allkilkdnp vtlkeigwdl pkgllqffsr kninvnihlv 61 fsplvssvme cfnelaingn pkeclltace lvstlhivlt etgdsdeene dlndsnrnda 121 snitdelsvi tpeighymak ntvefipnlk iyvlfefmsl llkrvdtlyp skflamvtsa 181 iikyvttnvq amddphfilr ivynfctnys paqpsasltd gistndleki hddesalqkk 241 llanlsvfvi snclknhpgn idkiyfktlm hkktdeneid asvlqichqy yeyvtsldvh 301 mkellekclv esrsiynsll mnpaastpef keeinqlvye vsyayqikkl adeknleldq 361 ygvvilsaih yskngthllp qidiqsaiyl ylrcttaslf seiyenkfle ssvrywlwvs 421 ttetstekik calqelpghi ttaflqmllm ktcnesnndt klteitllrr llylmpests 481 ftfifetllh cpyitakiav ldilrdmmir speaanrdet vglieqqnpg ntansvpimp 541 tlpprpyiti nedrmasihs ialicfsaak qkkrtqgdll lvltymkffv slrnkwdlgl 601 ltlinkeise sfqgegepel afinisnntl geyieemnir s // LOCUS NP_011456 491 aa linear PLN 30-JUN-2025 DEFINITION protein kinase PKP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011456 VERSION NP_011456.5 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180924.4 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08043. On Jul 30, 2012 this sequence version replaced NP_011456.4. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..491 /product="protein kinase PKP2" /EC_number="2.7.11.2" /calculated_mol_wt="57163" Region 79..244 /region_name="BCDHK_Adom3" /note="Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; pfam10436" /db_xref="CDD:463093" Region 248..477 /region_name="HATPase_PDK-like" /note="Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; cd16929" /db_xref="CDD:340406" Site order(280,327,329,331..334,336..338,342,347..349,462, 464..468,471,475) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:340406" Site order(300,304..305,307..308,339,341,343,345..346,354, 440..447,463,465,469..470,472) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:340406" Site order(355,446) /site_type="other" /note="ATP-lid" /db_xref="CDD:340406" CDS 1..491 /gene="PKP2" /locus_tag="YGL059W" /coded_by="NM_001180924.4:1..1476" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894|PMID:17918780]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:18180296|PMID:22842922|PMID:14562095|PMID:17918780|P MID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity [PMID:18180296]" /experiment="EXISTENCE:mutant phenotype:GO:1901524 regulation of mitophagy [PMID:31548421]" /note="Mitochondrial protein kinase; negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p; relocalizes from mitochondrion to cytoplasm upon DNA replication stress" /db_xref="GeneID:852821" /db_xref="SGD:S000003027" ORIGIN 1 mskyqincir yrhflrtsni sqipdftkyc igpvneelap yimetmkayp snseyinpqh 61 yyhnrtvlve nylkrspnpv sltqlaqyyd dstkltrtki insgkfvkee lviriahkln 121 qlqqlpfnvv nnfhfvqvye syynifesfr kyptirtled asqfadfikn mlegfntlnl 181 phlimgalec tildlyprek mdqllsdllr arisrrlive ehvsitanyt sgkeentlvl 241 gdifqecsak kylleasees qkfiqdmyfk dipmpefiie gdtqlsfyfl pthlkyllge 301 ilrntyeatm khyirkglek pepiivtvvs ndesylfris dkaggvlhdd enlwsfgksk 361 eraqeslnnf hklpglqtvs iydevhshtk ynsklkslqs itlkpymhts lepmsypsii 421 nghikyetpl iellkrsfry klgiglamck vyaeywngdl slhsmpgygt dvvlklgnlm 481 khtkklqldk v // LOCUS NP_011457 172 aa linear PLN 30-JUN-2025 DEFINITION E2 ubiquitin-conjugating protein RAD6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011457 VERSION NP_011457.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180923.1 REFERENCE 1 (residues 1 to 172) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 172) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 172) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 172) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08044. Method: conceptual translation. FEATURES Location/Qualifiers source 1..172 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..172 /product="E2 ubiquitin-conjugating protein RAD6" /EC_number="2.3.2.23" /calculated_mol_wt="19575" Region 3..145 /region_name="UBCc_UBE2A_2B" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzymes E2A, E2B and related proteins; cd23790" /db_xref="CDD:467410" CDS 1..172 /gene="RAD6" /locus_tag="YGL058W" /gene_synonym="PSO8; UBC2" /coded_by="NM_001180923.1:1..519" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:14752010]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:9287349]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:3306404|PMID:9287349]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10880451|PMID:8436296]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10880451]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:9287349]" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:10848595]" /experiment="EXISTENCE:direct assay:GO:0097505 Rad6-Rad18 complex [PMID:9287349]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:16783014]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:23988329]" /experiment="EXISTENCE:genetic interaction:GO:0042275 error-free postreplication DNA repair [PMID:9576943]" /experiment="EXISTENCE:genetic interaction:GO:0042276 error-prone translesion synthesis [PMID:770231]" /experiment="EXISTENCE:genetic interaction:GO:0070987 error-free translesion synthesis [PMID:9409821]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15504724|PMID:8436296]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:9343433|PMID:12535539]" /experiment="EXISTENCE:mutant phenotype:GO:0031571 mitotic G1 DNA damage checkpoint signaling [PMID:16166626|PMID:15632126]" /experiment="EXISTENCE:mutant phenotype:GO:0034620 cellular response to unfolded protein [PMID:20462952]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:15280549]" /experiment="EXISTENCE:mutant phenotype:GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway [PMID:8505328|PMID:1651502]" /experiment="EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:20462952]" /experiment="EXISTENCE:mutant phenotype:GO:0090089 regulation of dipeptide transport [PMID:9427760]" /experiment="EXISTENCE:mutant phenotype:GO:0120174 stress-induced homeostatically regulated protein degradation pathway [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:1990303 UBR1-RAD6 ubiquitin ligase complex [PMID:8505328]" /experiment="EXISTENCE:physical interaction:GO:0006366 transcription by RNA polymerase II [PMID:15632065]" /experiment="EXISTENCE:physical interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15504724]" /experiment="EXISTENCE:physical interaction:GO:1990303 UBR1-RAD6 ubiquitin ligase complex [PMID:8505328|PMID:1651502]" /experiment="EXISTENCE:physical interaction:GO:1990304 MUB1-RAD6-UBR2 ubiquitin ligase complex [PMID:18070918]" /note="Ubiquitin-conjugating enzyme (E2); involved in postreplication repair as a heterodimer with Rad18p, regulation of K63 polyubiquitination in response to oxidative stress, DSBR and checkpoint control as a heterodimer with Bre1p, ubiquitin-mediated N-end rule protein degradation as a heterodimer with Ubr1p, ERAD with Ubr1p in the absence of canonical ER membrane ligases, and Rpn4p turnover as part of proteasome homeostasis, in complex with Ubr2p and Mub1p" /db_xref="GeneID:852822" /db_xref="SGD:S000003026" ORIGIN 1 mstparrrlm rdfkrmkeda ppgvsasplp dnvmvwnami igpadtpyed gtfrlllefd 61 eeypnkpphv kflsemfhpn vyangeicld ilqnrwtpty dvasiltsiq slfndpnpas 121 panveaatlf kdhksqyvkr vketvekswe ddmddmdddd ddddddddde ad // LOCUS NP_011458 287 aa linear PLN 30-JUN-2025 DEFINITION Gep7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011458 VERSION NP_011458.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180922.1 REFERENCE 1 (residues 1 to 287) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 287) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 287) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 287) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08045. Method: conceptual translation. FEATURES Location/Qualifiers source 1..287 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..287 /product="Gep7p" /calculated_mol_wt="32828" CDS 1..287 /gene="GEP7" /locus_tag="YGL057C" /coded_by="NM_001180922.1:1..864" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14562095]" /note="hypothetical protein; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:852823" /db_xref="SGD:S000003025" ORIGIN 1 mvlsnvkifr lkshrafrig pmikavagnl lvkrfyqpkl erippaslll kqkirlaqng 61 sttstenpis fsqtmseifs vlqpsapdld edetsglkrd hllterlnng elgvimnkff 121 npssthnnql idtnillqnf pklsgndldl ldfainekmr gnwndlkqdf iqlwyyksfg 181 flgprtqfvl tnsspsvrsq flklpfieyn wfllqnnkna nilpadvqnv vkvfhlddkr 241 ftwksidpfs kaiisfvvfv siyvwldesa kqktkelpaq kstvise // LOCUS NP_011459 527 aa linear PLN 30-JUN-2025 DEFINITION Sds23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011459 VERSION NP_011459.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180921.2 REFERENCE 1 (residues 1 to 527) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 527) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 527) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 527) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08046. On Apr 26, 2011 this sequence version replaced NP_011459.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..527 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..527 /product="Sds23p" /calculated_mol_wt="57967" Region <175..319 /region_name="COG2524" /note="Predicted transcriptional regulator, contains C-terminal CBS domains [Transcription]" /db_xref="CDD:442013" Region 275..388 /region_name="COG3448" /note="CBS-domain-containing membrane protein [Signal transduction mechanisms]" /db_xref="CDD:442671" CDS 1..527 /gene="SDS23" /locus_tag="YGL056C" /coded_by="NM_001180921.2:1..1584" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000920 septum digestion after cytokinesis [PMID:16041152]" /note="Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; SDS23 has a paralog, SDS24, that arose from the whole genome duplication" /db_xref="GeneID:852824" /db_xref="SGD:S000003024" ORIGIN 1 mpqntrhtsi vemlstppql pnstdlnsls eqtdkntean ksdteslhks iskssssssl 61 stldnteysn nngnslstln sqnllsvhrq ewqhtplsnl veqnklifir gsisveeafn 121 tlvkhqltsl pvenfpgdmn cltfdyndln aylllvlnri kvsndkitsd cqngksvpvg 181 eivkltpknp fyklpetenl stvigilgsg vhrvaitnve mtqikgilsq rrlikylwen 241 arsfpnlkpl ldssleelni gvlnaardkp tfkqsrvisi qgdehlimal hkmyveriss 301 iavvdpqgnl ignisvtdvk hvtrtsqypl lhntcrhfvs vilnlrglet gkdsfpifhv 361 yptsslartf aklvatkshr lwivqpndnq ptasseksss pspstppvtt lpslassyhs 421 ntqssrmans pvlkssdtsn nkinvninls gpspsqpqsp satmpppqsp sncpasptpa 481 hfekeyrtgk ligvvsltdi lsvlarkqth hkeidpqmar kqrghig // LOCUS NP_011460 510 aa linear PLN 30-JUN-2025 DEFINITION stearoyl-CoA 9-desaturase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011460 VERSION NP_011460.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180920.3 REFERENCE 1 (residues 1 to 510) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 510) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 510) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 510) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08047. On Jul 30, 2012 this sequence version replaced NP_011460.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..510 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..510 /product="stearoyl-CoA 9-desaturase" /EC_number="1.14.19.1" /calculated_mol_wt="58272" Region 111..383 /region_name="OLE1" /note="Fatty-acid desaturase [Lipid transport and metabolism]; COG1398" /db_xref="CDD:441008" Region 413..487 /region_name="Cyt-b5" /note="Cytochrome b5-like Heme/Steroid binding domain; pfam00173" /db_xref="CDD:459698" CDS 1..510 /gene="OLE1" /locus_tag="YGL055W" /gene_synonym="MDM2" /coded_by="NM_001180920.3:1..1533" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12475963]" /experiment="EXISTENCE:genetic interaction:GO:0009055 electron transfer activity [PMID:8530368]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:2202739]" /experiment="EXISTENCE:mutant phenotype:GO:0004768 stearoyl-CoA 9-desaturase activity [PMID:1978720]" /experiment="EXISTENCE:mutant phenotype:GO:0006636 unsaturated fatty acid biosynthetic process [PMID:1978720]" /note="Delta(9) fatty acid desaturase; required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria" /db_xref="GeneID:852825" /db_xref="SGD:S000003023" ORIGIN 1 mptsgttiel iddqfpkdds assgivdevd lteanilatg lnkkaprivn gfgslmgske 61 mvsvefdkkg nekksnldrl lekdnqekee aktkihiseq pwtlnnwhqh lnwlnmvlvc 121 gmpmigwyfa lsgkvplhln vflfsvfyya vggvsitagy hrlwshrsys ahwplrlfya 181 ifgcasvegs akwwghshri hhrytdtlrd pydarrglwy shmgwmllkp npkykaradi 241 tdmtddwtir fqhrhyillm lltafviptl icgyffndym ggliyagfir vfviqqatfc 301 inslahyigt qpfddrrtpr dnwitaivtf gegyhnfhhe fptdyrnaik wyqydptkvi 361 iyltslvgla ydlkkfsqna ieealiqqeq kkinkkkaki nwgpvltdlp mwdkqtflak 421 skenkglvii sgivhdvsgy isehpggetl iktalgkdat kafsggvyrh snaaqnvlad 481 mrvavikesk nsairmaskr geiyetgkff // LOCUS NP_011461 138 aa linear PLN 30-JUN-2025 DEFINITION cornichon family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011461 VERSION NP_011461.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180919.1 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08048. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..138 /product="cornichon family protein" /calculated_mol_wt="15799" Region 3..124 /region_name="Cornichon" /note="Cornichon protein; pfam03311" /db_xref="CDD:460883" CDS 1..138 /gene="ERV14" /locus_tag="YGL054C" /coded_by="NM_001180919.1:1..417" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9732282]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:direct assay:GO:0038024 cargo receptor activity [PMID:23270647]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9732282]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:9732282]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:9732282]" /experiment="EXISTENCE:mutant phenotype:GO:0038024 cargo receptor activity [PMID:23270647]" /note="COPII-coated vesicle protein; involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p and Nha1p antiporter to cell surface; related to Drosophila cornichon; ERV14 has a paralog, ERV15, that arose from the whole genome duplication" /db_xref="GeneID:852826" /db_xref="SGD:S000003022" ORIGIN 1 mgawlfilav vvncinlfgq vhftilyadl eadyinpiel cskvnklitp eaalhgalsl 61 lfllngywfv fllnlpvlay nlnkiynkvq lldateifrt lgkhkresfl klgfhllmff 121 fylyrmimal iaesgddf // LOCUS NP_011462 237 aa linear PLN 30-JUN-2025 DEFINITION pheromone-regulated DUP240 family protein PRM8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011462 VERSION NP_011462.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180918.1 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08049. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..237 /product="pheromone-regulated DUP240 family protein PRM8" /calculated_mol_wt="27119" Region 80..171 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..237 /gene="PRM8" /locus_tag="YGL053W" /coded_by="NM_001180918.1:1..714" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12925749]" /experiment="EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:12101299]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12101299]" /note="Pheromone-regulated protein; contains with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family; PRM8 has a paralog, PRM9, that arose from a segmental duplication" /db_xref="GeneID:852828" /db_xref="SGD:S000003021" ORIGIN 1 mqtpsentna ksdsldepga ylieenvalp kdifhsylsy wiyeaahctp vmllslvigv 61 lisiiilfhd nencvgvsvg fllifsgilv ivlilrfgpq isdedfkckl lmeiitrkpt 121 vkgkewrtit ykmnqylfdn dlwntpyyfy rdedchryfl slikgrtfkk qkessasnvk 181 daqsndetag tpneaaesss fsagpnfikl ltkaaeieqq fqkeywrqey pgvdeff // LOCUS NP_011464 234 aa linear PLN 30-JUN-2025 DEFINITION DUP240 family protein MST27 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011464 VERSION NP_011464.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180916.1 REFERENCE 1 (residues 1 to 234) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 234) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 234) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 234) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08050. Method: conceptual translation. FEATURES Location/Qualifiers source 1..234 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..234 /product="DUP240 family protein MST27" /calculated_mol_wt="27110" Region <96..171 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..234 /gene="MST27" /locus_tag="YGL051W" /coded_by="NM_001180916.1:1..705" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12925749|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:12925749]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:12925749]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:12925749]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:12925749]" /experiment="EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:12101299]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12101299]" /note="Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles; MST27 has a paralog, MST28, that arose from a segmental duplication" /db_xref="GeneID:852830" /db_xref="SGD:S000003019" ORIGIN 1 mqtplestdv kldtlnepsa hlieknvalp kdifrsylsy wiyeiarytp vmilslvigv 61 lvlliiffnd neacvfnsay yaylslvvll iilgdgnpkl vsrrnfrtel lvdvitrkpa 121 vegkewriit ynmnqylfnh gqwhtpyyfy sdedcyryfl rlvegvtpkk qtatsignsp 181 vtakpedaie saspssrlny rnfllkaaei erqaqenywr rrhpnidall kkte // LOCUS NP_011465 273 aa linear PLN 30-JUN-2025 DEFINITION tRNA methyltransferase TYW3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011465 VERSION NP_011465.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180915.3 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08051. On Jul 30, 2012 this sequence version replaced NP_011465.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..273 /product="tRNA methyltransferase TYW3" /EC_number="2.1.1.282" /calculated_mol_wt="30675" Region 10..227 /region_name="TYW3" /note="Methyltransferase TYW3; pfam02676" /db_xref="CDD:460649" CDS 1..273 /gene="TYW3" /locus_tag="YGL050W" /coded_by="NM_001180915.3:1..822" /experiment="EXISTENCE:direct assay:GO:0008175 tRNA methyltransferase activity [PMID:16642040]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:16642040]" /experiment="EXISTENCE:mutant phenotype:GO:0008175 tRNA methyltransferase activity [PMID:16642040]" /experiment="EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:16642040]" /experiment="EXISTENCE:mutant phenotype:GO:0031591 wybutosine biosynthetic process [PMID:17150819|PMID:16642040]" /note="tRNA methyltransferase required for synthesis of wybutosine; a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions" /db_xref="GeneID:852832" /db_xref="SGD:S000003018" ORIGIN 1 maaqnafeqk krailneids tqpdlspkgt idelclpiid linasadmvt tsscsgrvsv 61 flegtksyng evkiggkgqg gkwlyvthdr ekvigwldel ksksefsfel sgkeiptekv 121 tgsiryilyk yepfilhvkc rdfqaaskly ntamscgfre sgigsnnlva irinikldvp 181 lgyldetsgt lkffvtpeyv svldslslsk fdentrkmqa lydriekeli ncapdvnskv 241 nitpietkee rrerkkregm erqrqlkspq nvl // LOCUS NP_011466 914 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF4G [Saccharomyces cerevisiae S288C]. ACCESSION NP_011466 VERSION NP_011466.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180914.1 REFERENCE 1 (residues 1 to 914) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 914) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 914) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 914) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08052. Method: conceptual translation. FEATURES Location/Qualifiers source 1..914 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..914 /product="translation initiation factor eIF4G" /calculated_mol_wt="103768" Region 381..440 /region_name="eIF_4G1" /note="Eukaryotic translation initiation factor 4G1; pfam12152" /db_xref="CDD:432365" Region 567..808 /region_name="MIF4G" /note="MIF4G domain; pfam02854" /db_xref="CDD:397130" CDS 1..914 /gene="TIF4632" /locus_tag="YGL049C" /coded_by="NM_001180914.1:1..2745" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:22851688|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:22851688]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:22851688]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:17908917|PMID:26777405|PMID:19470581]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:12861028]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:22851688]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:22851688]" /experiment="EXISTENCE:mutant phenotype:GO:0016281 eukaryotic translation initiation factor 4F complex [PMID:8336723]" /experiment="EXISTENCE:mutant phenotype:GO:0031369 translation initiation factor binding [PMID:22851688]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12861028]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:22851688]" /note="Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); proposed to stimulate the ATPase and helicase activities of eIF4A synergistically with eIF4G based on sequence similarity with Tif4631p; proposed to be required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; associated with Pab1p-mediated poly(A)-tail stimulated, translation" /db_xref="GeneID:852833" /db_xref="SGD:S000003017" ORIGIN 1 mtdqrgpppp hpqqangykk fpphdnqysg annsqpnnhy nenlysarep hnnkqyqskn 61 gkygtnkynn rnnsqgnaqy ynnrfnngyr lnnndynpam lpgmqwpany yapqmyyipq 121 qmvpvasppy thqplntnpe ppstpkttki eittktgerl nlkkfheekk askgeekndg 181 veqksksgtp fekeatpvlp aneavkdtlt etsnekstse aentkrlfle qvrlrkaame 241 rkkngliset ekkqetsnhd ntdttkpnsv iesepikeap kptgeanevv idgksgasvk 301 tpqhvtgsvt ksvtfnepen esssqdvdel vkdddtteis dttggktvnk sddetinsvi 361 tteentvket epstsdiemp tvsqlletlg kaqpisdiye faypenverp dikykkpsvk 421 ytygptfllq fkdklkfrpd pawveavssk ivipphiarn kpkdsgrfgg dfrspsmrgm 481 dhtsssrvss krrskrmgdd rrsnrgytsr kdrekaaeka eeqapkeeia plvpsanrwi 541 pksrvkktek klapdgktel fdkeeverkm ksllnkltle mfdsisseil dianqskwed 601 dgetlkivie qifhkacdep hwssmyaqlc gkvvkdldpn ikdkenegkn gpklvlhylv 661 archeefekg wadklpaged gnplepemms deyyiaaaak rrglglvrfi gylyclnllt 721 gkmmfecfrr lmkdlnndps eetlesviel lntvgeqfeh dkfvtpqatl egsvlldnlf 781 mllqhiidgg tisnrikfkl idvkelreik hwnsakkdag pktiqqihqe eeqlrqkkns 841 qrsnsrfnnh nqsnsnryss nrrnmqntqr dsfastktgs frnnqrnark veevsqapra 901 nmfdalmnnd gdsd // LOCUS NP_011467 405 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle base subunit RPT6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011467 VERSION NP_011467.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180913.1 REFERENCE 1 (residues 1 to 405) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 405) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 405) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 405) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08053. Method: conceptual translation. FEATURES Location/Qualifiers source 1..405 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..405 /product="proteasome regulatory particle base subunit RPT6" /calculated_mol_wt="45141" Region 12..399 /region_name="PRK03992" /note="proteasome-activating nucleotidase; Provisional" /db_xref="CDD:179699" CDS 1..405 /gene="RPT6" /locus_tag="YGL048C" /gene_synonym="CIM3; CRL3; SCB68; SUG1" /coded_by="NM_001180913.1:1..1218" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10419517]" /experiment="EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626|PMID:11742986]" /experiment="EXISTENCE:direct assay:GO:0019904 protein domain specific binding [PMID:7870180]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:genetic interaction:GO:0006289 nucleotide-excision repair [PMID:11410533]" /experiment="EXISTENCE:genetic interaction:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:16269334]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:20855529]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:11389845]" /experiment="EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:19843524]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:22505030]" /experiment="EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19412160]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:12447385|PMID:10688918]" /experiment="EXISTENCE:physical interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:10688918]" /note="ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852834" /db_xref="SGD:S000003016" ORIGIN 1 mtaavtssni vlethesgik pyfeqkiqet elkirskten vrrleaqrna lndkvrfikd 61 elrllqepgs yvgevikivs dkkvlvkvqp egkyivdvak dinvkdlkas qrvclrsdsy 121 mlhkvlenka dplvslmmve kvpdstydmv ggltkqikei kevielpvkh pelfeslgia 181 qpkgvilygp pgtgktllar avahhtdckf irvsgaelvq kyigegsrmv relfvmareh 241 apsiifmdei dsigstrveg sgggdsevqr tmlellnqld gfetskniki imatnrldil 301 dpallrpgri drkiefppps vaaraeilri hsrkmnltrg inlrkvaekm ngcsgadvkg 361 vcteagmyal rerrihvtqe dfelavgkvm nknqetaisv aklfk // LOCUS NP_011468 202 aa linear PLN 30-JUN-2025 DEFINITION N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011468 VERSION NP_011468.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180912.1 REFERENCE 1 (residues 1 to 202) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 202) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 202) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 202) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08054. Method: conceptual translation. FEATURES Location/Qualifiers source 1..202 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..202 /product="N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase catalytic subunit ALG13" /EC_number="2.4.1.141" /calculated_mol_wt="22530" Region 9..200 /region_name="Glycosyltransferase_GTB-type" /note="glycosyltransferase family 1 and related proteins with GTB topology; cl10013" /db_xref="CDD:471961" CDS 1..202 /gene="ALG13" /locus_tag="YGL047W" /coded_by="NM_001180912.1:1..609" /experiment="EXISTENCE:direct assay:GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [PMID:16100113]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591|PMID:16100110]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16100113|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:16100113]" /experiment="EXISTENCE:mutant phenotype:GO:0004577 N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity [PMID:16100113|PMID:15615718]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:16100113|PMID:15615718]" /experiment="EXISTENCE:physical interaction:GO:0043541 UDP-N-acetylglucosamine transferase complex [PMID:16100113|PMID:16100110]" /note="Catalytic component of UDP-GlcNAc transferase; required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases; protein abundance increases in response to DNA replication stress; both human homologs ALG13 and ALG14 are required to complement yeast alg13 mutant" /db_xref="GeneID:852835" /db_xref="SGD:S000003015" ORIGIN 1 mgiieekalf vtcgatvpfp klvscvlsde fcqeliqygf vrliiqfgrn yssefehlvq 61 erggqresqk ipidqfgcgd tarqyvlmng klkvigfdfs tkmqsiirdy sdlvishagt 121 gsildslrln kplivcvnds lmdnhqqqia dkfvelgyvw scaptetgli aglrasqtek 181 lkpfpvshnp sferllveti ys // LOCUS NP_011470 542 aa linear PLN 30-JUN-2025 DEFINITION Rim8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011470 VERSION NP_011470.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180910.3 REFERENCE 1 (residues 1 to 542) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 542) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 542) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 542) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08055. On Jul 30, 2012 this sequence version replaced NP_011470.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..542 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..542 /product="Rim8p" /calculated_mol_wt="60733" Region 39..201 /region_name="Arrestin_N" /note="Arrestin (or S-antigen), N-terminal domain; pfam00339" /db_xref="CDD:425619" Region 259..392 /region_name="Arrestin_C" /note="Arrestin (or S-antigen), C-terminal domain; pfam02752" /db_xref="CDD:460676" CDS 1..542 /gene="RIM8" /locus_tag="YGL045W" /gene_synonym="ART9; PAL3; YGL046W" /coded_by="NM_001180910.3:1..1629" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009898 cytoplasmic side of plasma membrane [PMID:20028738]" /experiment="EXISTENCE:mutant phenotype:GO:0070086 ubiquitin-dependent endocytosis [PMID:31658248]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:31658248]" /note="Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family" /db_xref="GeneID:852837" /db_xref="SGD:S000003013" ORIGIN 1 msllrlwnke srapskiksh givgsygnsm lahnnvkqfr ididephrvw kpnesitgea 61 vidikrditn vaiklslvce vrvktgnspt sknkriektl ekstflygqd yvktafsake 121 kkphvdktti lnglskgehr fpfririprg rgmlssikfe rgsityflsc tleslnning 181 lkkpearcer efavivpldv srlpkpktkt vvlqsasmvq nkknkstede sssytqltqk 241 sttsnsssss vnsktsplpn ktvtisvdip qagfmigeii pidvkidhyk pfyapagltt 301 tlvricrvgg agkddpmetf rkdicqsisp iyinpetlqf qsrvylkvpl dafstlttvg 361 kffsfqyyie vmvnlskknv vytesnriig tpigeqnglg venninriqr kmlrmvnpet 421 lendsegyes siffkdmvnv eklkrlrnvt gmsietvigt trseqqqsda sipsqssita 481 pqnspsnlrd wlaplnayds ddvpvpkysp ndkvsvpsed kqeleqkrlq qlesdpppcd 541 dy // LOCUS NP_011471 296 aa linear PLN 30-JUN-2025 DEFINITION Rna15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011471 VERSION NP_011471.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180909.1 REFERENCE 1 (residues 1 to 296) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 296) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 296) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 296) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08056. Method: conceptual translation. FEATURES Location/Qualifiers source 1..296 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..296 /product="Rna15p" /calculated_mol_wt="32660" Region 18..94 /region_name="RRM_CSTF2_RNA15_like" /note="RNA recognition motif (RRM) found in cleavage stimulation factor subunit 2 (CSTF2), yeast ortholog mRNA 3'-end-processing protein RNA15 and similar proteins; cd12398" /db_xref="CDD:409832" Site order(21,48..55,58,61..63,87,90..94) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:409832" Region 255..291 /region_name="CSTF_C" /note="Transcription termination and cleavage factor C-terminal; pfam14304" /db_xref="CDD:464130" CDS 1..296 /gene="RNA15" /locus_tag="YGL044C" /coded_by="NM_001180909.1:1..891" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:17684230]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11344258]" /experiment="EXISTENCE:physical interaction:GO:0005848 mRNA cleavage stimulating factor complex [PMID:11344258]" /note="Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signal in complex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability" /db_xref="GeneID:852838" /db_xref="SGD:S000003012" ORIGIN 1 mnrqsgvnag vqnnppsrvv ylgsipydqt eeqildlcsn vgpvinlkmm fdpqtgrskg 61 yafiefrdle ssasavrnln gyqlgsrflk cgyssnsdis gvsqqqqqqy nningnnnnn 121 gnnnnnsngp dfqnsgnanf lsqkfpelps gidvninmtt pammissela kkpkevqlkf 181 lqkfqewtra hpedavslle lcpqlsfvta ellltngick vddliplasr pqeeasatnn 241 nsvnevvdpa vlnkqkellk qvlqlndsqi silpdderma iwdlkqkalr gefgaf // LOCUS NP_011472 309 aa linear PLN 30-JUN-2025 DEFINITION transcription elongation factor DST1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011472 VERSION NP_011472.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180908.1 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08057. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..309 /product="transcription elongation factor DST1" /calculated_mol_wt="34712" Region 3..309 /region_name="TFSII" /note="transcription elongation factor S-II; TIGR01385" /db_xref="CDD:273592" CDS 1..309 /gene="DST1" /locus_tag="YGL043W" /gene_synonym="PPR2" /coded_by="NM_001180908.1:1..930" /experiment="EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:15767671]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9334234]" /experiment="EXISTENCE:direct assay:GO:0006362 transcription elongation by RNA polymerase I [PMID:7002153]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:17901206]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:8288647|PMID:7002153|PMID:9334234|PMID:7020755]" /experiment="EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:18628399]" /experiment="EXISTENCE:direct assay:GO:0031564 transcription antitermination [PMID:9169440|PMID:8636112|PMID:9037112]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:8876173]" /experiment="EXISTENCE:direct assay:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:17913884]" /experiment="EXISTENCE:genetic interaction:GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [PMID:17535246]" /experiment="EXISTENCE:genetic interaction:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:17901206]" /experiment="EXISTENCE:genetic interaction:GO:0031440 regulation of mRNA 3'-end processing [PMID:15531585]" /experiment="EXISTENCE:mutant phenotype:GO:0001139 RNA polymerase II complex recruiting activity [PMID:15767671]" /experiment="EXISTENCE:mutant phenotype:GO:0001193 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II [PMID:14531857|PMID:16492753]" /experiment="EXISTENCE:mutant phenotype:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:15767671|PMID:17901206]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:8288647]" /experiment="EXISTENCE:mutant phenotype:GO:0031440 regulation of mRNA 3'-end processing [PMID:15531585]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:18628399]" /experiment="EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:17913884]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:6985606|PMID:8876173]" /note="General transcription elongation factor TFIIS; enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites; maintains RNAPII elongation activity on ribosomal protein genes during conditions of transcriptional stress" /db_xref="GeneID:852839" /db_xref="SGD:S000003011" ORIGIN 1 mdskevlvhv knleknksnd aavleilhvl dkefvptekl lretkvgvev nkfkkstnve 61 isklvkkmis swkdainknk rsrqaqqhhq dhapgnaedk ttvgesvngv qqpassqsda 121 mkqdkyvstk prnskndgvd taiyhhklrd qvlkalydvl akesehppqs ilhtakaies 181 emnkvnncdt neaaykaryr iiysnviskn npdlkhkian gditpeflat cdakdlapap 241 lkqkieeiak qnlynaqgat iersvtdrft cgkckekkvs yyqlqtrsad eplttfctce 301 acgnrwkfs // LOCUS NP_878074 60 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL041C-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878074 VERSION NP_878074.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184550.1 REFERENCE 1 (residues 1 to 60) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 60) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 60) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 60) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08058. Method: conceptual translation. FEATURES Location/Qualifiers source 1..60 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..60 /product="uncharacterized protein" /calculated_mol_wt="6863" CDS 1..60 /locus_tag="YGL041C-B" /coded_by="NM_001184550.1:1..183" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum" /db_xref="GeneID:1466454" /db_xref="SGD:S000028548" ORIGIN 1 mfdssiervt lelcfhitls imcgcsiyfl llvfiltfys svllhlklyf fssdraifna // LOCUS NP_001106172 154 aa linear PLN 30-JUN-2025 DEFINITION Dpc13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001106172 VERSION NP_001106172.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184647.4 REFERENCE 1 (residues 1 to 154) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 154) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 154) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 154) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08059. On Jul 30, 2012 this sequence version replaced NP_001106172.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..154 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..154 /product="Dpc13p" /calculated_mol_wt="17972" CDS 1..154 /gene="DPC13" /locus_tag="YGL041W-A" /coded_by="NM_001184647.4:1..465" /note="Putative mitochondrial hypothetical protein; conserved in fungi; identified by expression profiling and mass spectrometry" /db_xref="GeneID:5814844" /db_xref="SGD:S000028826" ORIGIN 1 mlrviwkhss rvtrsielsn isttnhtrsl rrlswisprr fyaqswddrq pndkidahik 61 vqklmdqins rpnvleklek vsnimiekkl vnldgtsane entmkpwqmi kilmdrdlrh 121 amkefklele ksgiqlgpeq laplmtvlgl ekkk // LOCUS NP_011475 342 aa linear PLN 30-JUN-2025 DEFINITION porphobilinogen synthase HEM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011475 VERSION NP_011475.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180905.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08060. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..342 /product="porphobilinogen synthase HEM2" /EC_number="4.2.1.24" /calculated_mol_wt="37609" Region 20..338 /region_name="eu_ALAD_PBGS_cysteine_rich" /note="Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; cd04824" /db_xref="CDD:240128" Site order(31,158,181,183,213..215,218,233..235,239..240,242, 248,255,267..270,295,298,302,310,313,320..321) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:240128" Site order(131,133,135,143,179,210,216,219..220,225,232,236,263, 287,290,329) /site_type="active" /db_xref="CDD:240128" Site order(133,135,143) /site_type="other" /note="Cysteine-rich active site metal binding" /db_xref="CDD:240128" Site order(210,263) /site_type="active" /note="Schiff base residues [active]" /db_xref="CDD:240128" CDS 1..342 /gene="HEM2" /locus_tag="YGL040C" /gene_synonym="OLE4; SLU1" /coded_by="NM_001180905.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0004655 porphobilinogen synthase activity [PMID:2204246]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:8973546]" /experiment="EXISTENCE:mutant phenotype:GO:0004655 porphobilinogen synthase activity [PMID:323256|PMID:2445751]" /experiment="EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:323256|PMID:14559249]" /note="Aminolevulinate dehydratase; a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus; human homolog ALAD can complement yeast hem2 mutant" /db_xref="GeneID:852842" /db_xref="SGD:S000003008" ORIGIN 1 mhtaeflete pteissvlag gynhpllrqw qserqltknm lifplfisdn pddfteidsl 61 pninrigvnr lkdylkplva kglrsvilfg vplipgtkdp vgtaaddpag pviqgikfir 121 eyfpelyiic dvclceytsh ghcgvlyddg tinrersvsr laavavnyak agahcvapsd 181 midgrirdik rglinanlah ktfvlsyaak fsgnlygpfr daacsapsng drkcyqlppa 241 grglarrale rdmsegadgi ivkpstfyld imrdaseick dlpicayhvs geyamlhaaa 301 ekgvvdlkti afeshqgflr agarliityl apefldwlde en // LOCUS NP_011476 348 aa linear PLN 30-JUN-2025 DEFINITION carbonyl reductase (NADPH-dependent) [Saccharomyces cerevisiae S288C]. ACCESSION NP_011476 VERSION NP_011476.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180904.1 REFERENCE 1 (residues 1 to 348) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 348) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 348) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 348) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08061. Method: conceptual translation. FEATURES Location/Qualifiers source 1..348 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..348 /product="carbonyl reductase (NADPH-dependent)" /calculated_mol_wt="38128" Region 7..324 /region_name="AR_SDR_e" /note="aldehyde reductase, extended (e) SDRs; cd05227" /db_xref="CDD:187538" Site order(12,14..17,37,63,86..90,130..132,170,174,201..204, 220..221) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:187538" Site order(90,92,132..134,137,170,201..203,224,236,243,314) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:187538" Site order(132,170,174) /site_type="active" /db_xref="CDD:187538" CDS 1..348 /locus_tag="YGL039W" /coded_by="NM_001180904.1:1..1047" /experiment="EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:25656103]" /experiment="EXISTENCE:direct assay:GO:0004090 carbonyl reductase (NADPH) activity [PMID:18630881|PMID:19016485]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008152 metabolic process [PMID:16268655]" /experiment="EXISTENCE:direct assay:GO:0016614 oxidoreductase activity, acting on CH-OH group of donors [PMID:14574691|PMID:16268655]" /experiment="EXISTENCE:direct assay:GO:0042180 ketone metabolic process [PMID:16268655|PMID:14574691]" /experiment="EXISTENCE:mutant phenotype:GO:1901426 response to furfural [PMID:25656103]" /note="Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols" /db_xref="GeneID:852844" /db_xref="SGD:S000003007" ORIGIN 1 mttektvvfv sgatgfialh vvddllktgy kvigsgrsqe kndgllkkfk snpnlsmeiv 61 ediaapnafd kvfqkhgkei kvvlhiaspv hfnttdfekd llipavngtk sileaiknya 121 adtvekvvit ssvaalaspg dmkdtsfvvn eeswnkdtwe scqanavsay cgskkfaekt 181 awdfleenqs sikftlstin pgfvfgpqlf adslrngins ssaiianlvs yklgdnfyny 241 sgpfidvrdv skahllafek pecagqrlfl cedmfcsqea ldilneefpq lkgkiatgep 301 gsgstfltkn cckcdnrktk nllgfqfnkf rdcivdtasq llevqsks // LOCUS NP_011477 480 aa linear PLN 30-JUN-2025 DEFINITION initiation-specific alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011477 VERSION NP_011477.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180903.1 REFERENCE 1 (residues 1 to 480) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 480) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 480) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 480) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08062. Method: conceptual translation. FEATURES Location/Qualifiers source 1..480 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..480 /product="initiation-specific alpha-1,6-mannosyltransferase" /EC_number="2.4.1.232" /calculated_mol_wt="55025" Region 114..206 /region_name="Gly_transf_sug" /note="Glycosyltransferase sugar-binding region containing DXD motif; pfam04488" /db_xref="CDD:398274" CDS 1..480 /gene="OCH1" /locus_tag="YGL038C" /gene_synonym="LDB12; NGD29" /coded_by="NM_001180903.1:1..1443" /experiment="EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:9276464|PMID:17042779]" /experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:10189369|PMID:1628616]" /experiment="EXISTENCE:mutant phenotype:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:8253757]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:7649302]" /note="Mannosyltransferase of the cis-Golgi apparatus; initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins" /db_xref="GeneID:852845" /db_xref="SGD:S000003006" ORIGIN 1 msrklshlia trksktivvt vlliyslltf hlsnkrllsq fypskddfkq tllpttshsq 61 dinlkkqitv nkkknqlhnl rdqlsfafpy dsqapipqrv wqtwkvgadd knfpssfrty 121 qktwsgsysp dyqyslisdd siipflenly apvpiviqaf klmpgnilka dflrylllfa 181 rggiysdmdt mllkpidswp sqnkswlnni idlnkpipyk nskpsllssd eishqpglvi 241 gieadpdrdd wsewyarriq fcqwtiqakp ghpilrelil nitattlasv qnpgvpvsem 301 idprfeedyn vnyrhkrrhd etykhselkn nknvdgsdim nwtgpgifsd iifeymnnvl 361 rynsdillin pnlnkndeeg sesattpakd vdndtlskst rkfykkises lqssnsmpwe 421 ffsflkepvi vddvmvlpit sfspdvgqmg aqssddkmaf vkhmfsgswk edadknaghk // LOCUS NP_011478 216 aa linear PLN 30-JUN-2025 DEFINITION nicotinamidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011478 VERSION NP_011478.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180902.3 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08063. On Jul 30, 2012 this sequence version replaced NP_011478.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..216 /product="nicotinamidase" /EC_number="3.5.1.19" /calculated_mol_wt="24862" Region 1..214 /region_name="nicotinamidase" /note="Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; cd01011" /db_xref="CDD:238493" Site order(8,122,167) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:238493" Site order(51,53,94) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:238493" Site 162..163 /site_type="active" /note="conserved cis-peptide bond [active]" /db_xref="CDD:238493" CDS 1..216 /gene="PNC1" /locus_tag="YGL037C" /coded_by="NM_001180902.3:1..651" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12736687]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12736687|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:12736687]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:11901108]" /experiment="EXISTENCE:mutant phenotype:GO:0008936 nicotinamidase activity [PMID:19381334]" /experiment="EXISTENCE:mutant phenotype:GO:0019358 nicotinate nucleotide salvage [PMID:11901108]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11901108]" /experiment="EXISTENCE:mutant phenotype:GO:1904524 negative regulation of DNA amplification [PMID:26195783]" /note="Nicotinamidase that converts nicotinamide to nicotinic acid; part of the NAD(+) salvage pathway; required for life span extension by calorie restriction; lacks a peroxisomal targeting signal but is imported into peroxisomes via binding to Gpd1p; PNC1 expression responds to all known stimuli that extend replicative life span; protein increases in abundance and relative distribution to cytoplasmic foci decreases upon DNA replication stress" /db_xref="GeneID:852846" /db_xref="SGD:S000003005" ORIGIN 1 mktlivvdmq ndfisplgsl tvpkgeelin pisdlmqdad rdwhrivvtr dwhpsrhisf 61 aknhkdkepy stytyhsprp gddstqegil wpvhcvkntw gsqlvdqimd qvvtkhikiv 121 dkgfltdrey ysafhdiwnf hktdmnkyle khhtdevyiv gvaleycvka taisaaelgy 181 kttvlldytr pisddpevin kvkeelkahn invvdk // LOCUS NP_011479 909 aa linear PLN 30-JUN-2025 DEFINITION Vir1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011479 VERSION NP_011479.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180901.1 REFERENCE 1 (residues 1 to 909) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 909) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 909) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 909) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 909) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 909) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 909) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 909) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08064. Method: conceptual translation. FEATURES Location/Qualifiers source 1..909 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..909 /product="Vir1p" /calculated_mol_wt="102241" CDS 1..909 /gene="VIR1" /locus_tag="YGL036W" /coded_by="NM_001180901.1:1..2730" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:37603553]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:36930734]" /experiment="EXISTENCE:physical interaction:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:36930734]" /note="Protein required for mRNA m6A methylation and meiosis; subunit of the m6A methyltransferase (MIS) complex; required for the stability of MIS complex subunits and consistent with a scaffolding function; non-essential gene required for pre-meiotic S-phase; may be required to initiate the meiotic program, for progression through meiotic divisions and for spore formation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of VIRMA/virilizer/VIR" /db_xref="GeneID:852847" /db_xref="SGD:S000003004" ORIGIN 1 mqkcaghapl vtaasrvsqd tvdallqail kayhklasid shindpveia fklinsfkyl 61 pisgssvkdf eselreldvf spllqsavta annsniiwdl iavlfayisi hkqlhplilh 121 nlniwkdfma dndeetattt dgdsmnfgvl sllsivqnfe eitpnlfefl klglrstllk 181 iwvaqwqryd psatnlingd ekisswitkd yqvdffiits lastsslevl pshyfvykis 241 krishfpnli dpklyrsais timengisdn gggenssdki dptdlsfhlq vlmevidhpe 301 lnylqenrli llldialnyl ilvpthclhs nfgelgstqs lastlniiqf llskflinmg 361 sisqlinqyn rkcittnnin nnninnngvi ngstnttstt tttitnnnnn snnssisnnn 421 rkidwtqsyq tryqipywfe dsilppippi skslftfdkn ldhesdsimi vndvlrclnl 481 tilliskllr dyddlkinpl iqssddhsne dnhviieqym qlylvplfts lllaqqlkdr 541 gqerdeghke keeninligs ssvkklfsql iffsslklce nlvikeknla lyhlikfatk 601 vslddlilqk isinllnhlf fhqirdgsdd dnlikklclk nqlsfqalkd yitlwndgse 661 vynafykelf yeeqpkikpi klttsdllkl fpedvqfvis tppntitsas tsdnctssqs 721 aaqknienft tlskydvyss tsfipstskn tntnvskqqq qpqnstpcss nrflfnkssl 781 isqesngsnn nsgtqgpgsm nesysldnsf nttntnmtrq pttltratda mttapttpip 841 ykntsgssnn nlwiespmtn fkgstiskst nkskmvntgk nyilgghnkv knnsraqsih 901 iddfenenn // LOCUS NP_011480 504 aa linear PLN 30-JUN-2025 DEFINITION transcription factor MIG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011480 VERSION NP_011480.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180900.1 REFERENCE 1 (residues 1 to 504) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 504) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 504) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 504) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08065. Method: conceptual translation. FEATURES Location/Qualifiers source 1..504 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..504 /product="transcription factor MIG1" /calculated_mol_wt="55401" Region 5..>413 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 40..60 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 68..90 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..504 /gene="MIG1" /locus_tag="YGL035C" /gene_synonym="CAT4; SSN1; TDS22" /coded_by="NM_001180900.1:1..1515" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8114729|PMID:12239282|PMID:9832517]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517|PMID:7724528]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17237508|PMID:11914276|PMID:9285828]" /experiment="EXISTENCE:direct assay:GO:0005641 nuclear envelope lumen [PMID:17237508]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17237508|PMID:11914276|PMID:9285828]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]" /experiment="EXISTENCE:genetic interaction:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:7724528|PMID:9832517]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9832517]" /experiment="EXISTENCE:genetic interaction:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:22904036]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9832517]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9832517]" /note="Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion; activated in stochastic pulses of nuclear localization, shuttling between cytosol and nucleus depending on external glucose levels and its phosphorylation state" /db_xref="GeneID:852848" /db_xref="SGD:S000003003" ORIGIN 1 mqspypmtqv snvddgsllk eskskskvaa kseaprphac pichrafhrl ehqtrhmrih 61 tgekphacdf pgcvkrfsrs deltrhrrih tnshprgkrg rkkkvvgspi nsasssatsi 121 pdlntanfsp plpqqhlspl ipiaiapken ssrsstrkgr ktkfeigesg gndpymvssp 181 ktmakipvsv kpppslalnn mnyqtssast alsslsnshs gsrlklnals slqmmtpias 241 saprtvfidg peqkqlqqqq nslsprysnt vilprprslt dfqglnnanp nnngslraqt 301 qssvqlkrps svlslndllv gqrntnesds dfttggedee dglkdpsnss idnleqdylq 361 eqsrkkskts tpttmlsrst sgtnlhtlgy vmnqnhlhfs ssspdfqkel nnrllnvqqq 421 qqeqhtllqs qntsnqsqnq nqnqmmasss slsttpllls prvnmintai stqqtpisqs 481 dsqvqeletl ppirslplpf phmd // LOCUS NP_001335778 121 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL034C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335778 VERSION NP_001335778.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348837.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80298. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..121 /product="uncharacterized protein" /calculated_mol_wt="13442" CDS 1..121 /locus_tag="YGL034C" /coded_by="NM_001348837.1:1..366" /note="hypothetical protein; conserved among S. cerevisiae strains; YGL034C is not an essential gene" /db_xref="GeneID:852849" /db_xref="SGD:S000003002" ORIGIN 1 mnvvaiimas qetcsgrapr etpewrrpac lvasilvral efswlfstcl lvafdfardc 61 glpphsgktw sdgkgpaals fgktntkeat tnfynrldek sgeeqaekrk ensrswiiyl 121 l // LOCUS NP_011482 214 aa linear PLN 30-JUN-2025 DEFINITION Hop2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011482 VERSION NP_011482.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180898.2 REFERENCE 1 (residues 1 to 214) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 214) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 214) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 214) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08066. On Feb 18, 2015 this sequence version replaced NP_011482.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..214 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..214 /product="Hop2p" /calculated_mol_wt="24348" Region 18..79 /region_name="TBPIP" /note="TBPIP/Hop2 winged helix domain; pfam07106" /db_xref="CDD:429296" CDS 1..214 /gene="HOP2" /locus_tag="YGL033W" /coded_by="NM_001180898.2:1..645" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9708739]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:15249670]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:9708739]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:16581767]" /note="Meiosis-specific protein that localizes to chromosomes; prevents synapsis between nonhomologous chromosomes and ensures synapsis between homologs; forms complex with Mnd1p to promote homolog pairing and meiotic double-strand break repair; heterodimer of Hop2p-Mnd1p stimulates the Dmc1p-mediated strand invasion" /db_xref="GeneID:852850" /db_xref="SGD:S000003001" ORIGIN 1 mapkkksndr aiqakgseae qliedylvsq ykpfsvndiv qnlhnkvtkt tatkalenlv 61 nekrivsktf gkiiiyscne qdtalpsnid psqfdfetvl qlrndliele rdkstakdal 121 dsvtkepene dlltiienee nelkkieskl qslqddwdpa ndeivkrims edtllqkeit 181 krskicknli atikdsvcpk nmnefleeig fedi // LOCUS NP_011483 87 aa linear PLN 30-JUN-2025 DEFINITION Aga2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011483 VERSION NP_011483.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180897.3 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08067. On Jul 30, 2012 this sequence version replaced NP_011483.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..87 /product="Aga2p" /calculated_mol_wt="9333" Region 27..87 /region_name="AGA2" /note="A-agglutinin-binding subunit Aga2; pfam17366" /db_xref="CDD:375157" CDS 1..87 /gene="AGA2" /locus_tag="YGL032C" /coded_by="NM_001180897.3:1..264" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000752 agglutination involved in conjugation with cellular fusion [PMID:1756718]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:1756718]" /experiment="EXISTENCE:direct assay:GO:0050839 cell adhesion molecule binding [PMID:7957044|PMID:11292808]" /note="Adhesion subunit of a-agglutinin of a-cells; C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds" /db_xref="GeneID:852851" /db_xref="SGD:S000003000" ORIGIN 1 mqllrcfsif sviasvlaqe ltticeqips ptlestpysl stttilangk amqgvfeyyk 61 svtfvsncgs hpsttskgsp intqyvf // LOCUS NP_011484 155 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL24 RPL24A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011484 VERSION NP_011484.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180896.1 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08068. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..155 /product="60S ribosomal protein eL24 RPL24A" /calculated_mol_wt="17482" Region 2..64 /region_name="Ribosomal_L24e" /note="Ribosomal protein L24e; pfam01246" /db_xref="CDD:460131" CDS 1..155 /gene="RPL24A" /locus_tag="YGL031C" /gene_synonym="RPL30A" /coded_by="NM_001180896.1:1..468" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:30407570]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:30407570]" /note="Ribosomal 60S subunit protein L24A; forms two bridges within ribosome, stimulates translation initiation and elongation; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24A has a paralog, RPL24B, that arose from the whole genome duplication" /db_xref="GeneID:852852" /db_xref="SGD:S000002999" ORIGIN 1 mkveidsfsg akiypgrgtl fvrgdskifr fqnsksaslf kqrknprria wtvlfrkhhk 61 kgiteevakk rsrktvkaqr pitgasldli kerrslkpev rkanreeklk ankekkkaek 121 aarkaekaks agtqsskfsk qqakgafqkv aatsr // LOCUS NP_011485 105 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL30 RPL30 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011485 VERSION NP_011485.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180895.1 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08069. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..105 /product="60S ribosomal protein eL30 RPL30" /calculated_mol_wt="11284" Region 5..104 /region_name="PTZ00106" /note="60S ribosomal protein L30; Provisional" /db_xref="CDD:185450" CDS 1..105 /gene="RPL30" /locus_tag="YGL030W" /coded_by="NM_001180895.1:1..318" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:14970382]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9121443]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11142377]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]" /experiment="EXISTENCE:genetic interaction:GO:0030627 pre-mRNA 5'-splice site binding [PMID:18570876]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9121443]" /experiment="EXISTENCE:mutant phenotype:GO:0030627 pre-mRNA 5'-splice site binding [PMID:18570876]" /experiment="EXISTENCE:mutant phenotype:GO:0048025 negative regulation of mRNA splicing, via spliceosome [PMID:18570876|PMID:9121443]" /note="Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog" /db_xref="GeneID:852853" /db_xref="SGD:S000002998" ORIGIN 1 mapvksqesi nqklalviks gkytlgykst vkslrqgksk liiiaantpv lrkseleyya 61 mlsktkvyyf qggnnelgta vgklfrvgvv sileagdsdi lttla // LOCUS NP_011486 120 aa linear PLN 30-JUN-2025 DEFINITION Cgr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011486 VERSION NP_011486.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180894.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08070. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..120 /product="Cgr1p" /calculated_mol_wt="14286" Region 12..119 /region_name="Cgr1" /note="Cgr1 family; pfam03879" /db_xref="CDD:427562" CDS 1..120 /gene="CGR1" /locus_tag="YGL029W" /coded_by="NM_001180894.1:1..363" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11116400]" /experiment="EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:11932453]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:11116400]" /note="Protein involved in nucleolar integrity and processing of pre-rRNA; has a role in processing rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress; relocalizes from nucleus to nucleolus upon DNA replication stress" /db_xref="GeneID:852854" /db_xref="SGD:S000002997" ORIGIN 1 mvnetgesqk aakgtpvsgk vwkaektplr aksrvvknkk ltswelkkqk rledkqfker 61 lkalkdekee arqakitmlk errekkeene ryerlaakmh akkvermrrr ekrnkalker // LOCUS NP_011487 542 aa linear PLN 30-JUN-2025 DEFINITION putative glucan endo-1,3-beta-D-glucosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011487 VERSION NP_011487.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180893.3 REFERENCE 1 (residues 1 to 542) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 542) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 542) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 542) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08071. On Jul 30, 2012 this sequence version replaced NP_011487.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..542 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..542 /product="putative glucan endo-1,3-beta-D-glucosidase" /calculated_mol_wt="56316" CDS 1..542 /gene="SCW11" /locus_tag="YGL028C" /coded_by="NM_001180893.3:1..1629" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9748433]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p" /db_xref="GeneID:852856" /db_xref="SGD:S000002996" ORIGIN 1 mispisflss llcltyltsa lpilpkrevv trvhtasttn vvtdfysttt evviaptvef 61 lisdsvtftt tlipqgvnpt aeptttitkv llkkaemsts sqptstlqps tipqstssfq 121 aestlqavst qqtamsvsag tsedvqqlat tstsisssps ptttststqn ivsgvgeanv 181 egntqsqhhs yqaaatstln qqtstsiasq estestntpt ssstssstss stssstssst 241 ssstssstss stssstsstq etaattsegs ssssaaitss pkaiayspyn ddgscksada 301 vssdltliks kgiskirvyg tdcnsfetvq paavklgiki nqglyitssg vdsiddsvtt 361 liqygqtngw dvfdfitvgn eainngwcsv sdliskissv ksklseagys gqittseppv 421 sfennpdlck ksdidfvgin phayfdtsas aetagtfvkg qveliqgvcg tsnvfvtetg 481 ypssgiqngg nipstanqit avqnilnemd ldvtilstyn dywkapgdyg ieqsfgviey 541 fp // LOCUS NP_011488 833 aa linear PLN 30-JUN-2025 DEFINITION mannosyl-oligosaccharide glucosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011488 VERSION NP_011488.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180892.1 REFERENCE 1 (residues 1 to 833) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 833) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 833) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 833) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08072. Method: conceptual translation. FEATURES Location/Qualifiers source 1..833 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..833 /product="mannosyl-oligosaccharide glucosidase" /EC_number="3.2.1.106" /calculated_mol_wt="96376" Region 44..266 /region_name="Glyco_hydro_63N" /note="Glycosyl hydrolase family 63 N-terminal domain; pfam16923" /db_xref="CDD:465316" Region 319..832 /region_name="Glyco_hydro_63" /note="Glycosyl hydrolase family 63 C-terminal domain; pfam03200" /db_xref="CDD:397353" CDS 1..833 /gene="CWH41" /locus_tag="YGL027C" /gene_synonym="DER7; GLS1" /coded_by="NM_001180892.1:1..2502" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [PMID:14680956]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8576053]" /experiment="EXISTENCE:genetic interaction:GO:0070880 fungal-type cell wall beta-glucan biosynthetic process [PMID:9430631]" /experiment="EXISTENCE:mutant phenotype:GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity [PMID:9430631]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9363442]" /experiment="EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:9430631]" /note="Processing alpha glucosidase I; ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress" /db_xref="GeneID:852857" /db_xref="SGD:S000002995" ORIGIN 1 mliskskmfk tfwiltsivl lasatvdisk lqefeeyqkf tnesllwapy rsncyfgmrp 61 ryvhesplim gimwfnslsq dglhslrhfa tpqdklqkyg wevydprigg kevfideknn 121 lnltvyfvks kngenwsvrv qgepldpkrp stasvvlyfs qnggeidgks slamighdgp 181 ndmkffgysk elgeyhltvk dnfghyfknp eyetmevapg sdcsktshls lqipdkevwk 241 ardvfqslvs dsirdileke etkqrpadli psvltirnly nfnpgnfhyi qktfdltkkd 301 gfqfditynk lgttqsistr eqvtelitws lneinarfdk qfsfgegpds iesvevkrrf 361 aletlsnllg gigyfygnql idretefdes qfteikllna keegpfelft svpsrgffpr 421 gfywdegfhl lqimeydfdl afeilaswfe mieddsgwia reiilgnear skvpqefqvq 481 npnianpptl llafsemlsr aienigdfns dsyhqvmfns rtakfmtnnl eanpglltey 541 akkiypkllk hynwfrksqt glideyeeil edegiwdkih knevyrwvgr tfthclpsgm 601 ddypraqppd vaelnvdala wvgvmtrsmk qiahvlkltq deqryaqieq evvenldllh 661 wsendncycd isidpeddei refvchegyv svlpfalkli pknspklekv valmsdpeki 721 fsdygllsls rqddyfgkde nywrgpiwmn inylcldamr yyypevildv ageasnakkl 781 yqslkinlsn niykvweeqg ycyenyspid ghgtgaehft gwtalvvnil grf // LOCUS NP_011489 707 aa linear PLN 30-JUN-2025 DEFINITION tryptophan synthase TRP5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011489 VERSION NP_011489.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180891.1 REFERENCE 1 (residues 1 to 707) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 707) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 707) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 707) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08073. Method: conceptual translation. FEATURES Location/Qualifiers source 1..707 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..707 /product="tryptophan synthase TRP5" /EC_number="4.2.1.20" /calculated_mol_wt="76495" Region 9..259 /region_name="Trp_syntA" /note="Tryptophan synthase alpha chain; pfam00290" /db_xref="CDD:395227" Site order(50,61,65,176,184..185,214..215,235..236) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:240075" Site order(50,61,103,184) /site_type="active" /db_xref="CDD:240075" Site order(50,61,103) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:240075" Site order(55..58,60,63,66..67,105,108,130..131,133,136,156, 158..160,163) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:240075" Region 305..688 /region_name="TrpB" /note="Tryptophan synthase beta chain [Amino acid transport and metabolism]; COG0133" /db_xref="CDD:439903" CDS 1..707 /gene="TRP5" /locus_tag="YGL026C" /coded_by="NM_001180891.1:1..2124" /experiment="EXISTENCE:direct assay:GO:0004834 tryptophan synthase activity [PMID:391563|PMID:6342605]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000162 L-tryptophan biosynthetic process [PMID:10790693]" /note="Tryptophan synthase; catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis" /db_xref="GeneID:852858" /db_xref="SGD:S000002994" ORIGIN 1 mseqlrqtfa nakkenrnal vtfmtagypt vkdtvpilkg fqdggvdiie lgmpfsdpia 61 dgptiqlsnt valqngvtlp qtlemvsqar negvtvpiil mgyynpilny geerfiqdaa 121 kagangfiiv dlppeealkv rnyindngls liplvapstt derlellshi adsfvyvvsr 181 mgttgvqssv asdldelisr vrkytkdtpl avgfgvstre hfqsvgsvad gvvigskivt 241 lcgdapegkr ydvakeyvqg ilngakhkvl skdeffafqk eslksanvkk eildefdenh 301 khpirfgdfg gqyvpealha clrelekgfd eavadptfwe dfkslysyig rpsslhkaer 361 ltehcqgaqi wlkredlnht gshkinnala qvllakrlgk knviaetgag qhgvatatac 421 akfgltctvf mgaedvrrqa lnvfrmrilg akviavtngt ktlrdatsea frfwvtnlkt 481 tyyvvgsaig phpyptlvrt fqsvigketk eqfaamnngk lpdavvacvg ggsnstgmfs 541 pfehdtsvkl lgveaggdgv dtkfhsatlt agrpgvfhgv ktyvlqdsdg qvhdthsvsa 601 gldypgvgpe laywkstgra qfiaatdaqa llgfkllsql egiipaless havygacela 661 ktmkpdqhlv inisgrgdkd vqsvaevlpk lgpkigwdlr feedpsa // LOCUS NP_011490 397 aa linear PLN 30-JUN-2025 DEFINITION Pgd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011490 VERSION NP_011490.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180890.1 REFERENCE 1 (residues 1 to 397) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 397) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 397) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 397) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08074. On Oct 2, 2003 this sequence version replaced NP_011490.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..397 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..397 /product="Pgd1p" /calculated_mol_wt="42948" Region 3..397 /region_name="Med3" /note="Mediator complex subunit 3 fungal; pfam11593" /db_xref="CDD:402954" CDS 1..397 /gene="PGD1" /locus_tag="YGL025C" /gene_synonym="HRS1; MED3" /coded_by="NM_001180890.1:1..1194" /experiment="EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11073972]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10722672]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15254252]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12558798]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12482986]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:10722672]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor" /db_xref="GeneID:852860" /db_xref="SGD:S000002993" ORIGIN 1 mdsiipagvk lddlqvilak nenetrdkvc kqineardei lplrlqfnef iqimanidqe 61 gskqadrmak ylhirdkilq lndrfqtlss hlealqplfs tvpeylktad nrdrsfqlle 121 plstynkngn avcstatvvs tnhsaaastp tttatphanp ithahslsnp nstatmqhnp 181 lagkrgpksg stmgtptvhn staaapiaap kkprkprqtk kakaqaqaqa qaqaqvyaqq 241 stvqtpitas maaalpnptp sminsvsptn vmgtpltnmm spmgnaysmg aqnqggqvsm 301 sqfngsgngs npntntnsnn tplqsqlnln nltpanilnm smnndfqqqq qqqqqqqqpq 361 pqynmnmgmn nmnnggkeld sldlnnlelg glnmdfl // LOCUS NP_011492 635 aa linear PLN 30-JUN-2025 DEFINITION Pib2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011492 VERSION NP_011492.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180888.3 REFERENCE 1 (residues 1 to 635) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 635) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 635) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 635) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08075. On Jul 30, 2012 this sequence version replaced NP_011492.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..635 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..635 /product="Pib2p" /calculated_mol_wt="70486" Region 446..530 /region_name="FYVE" /note="Protein present in Fab1, YOTB, Vac1, and EEA1; smart00064" /db_xref="CDD:214499" CDS 1..635 /gene="PIB2" /locus_tag="YGL023C" /coded_by="NM_001180888.3:1..1908" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:29698392]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0140785 amino acid sensor activity [PMID:34535752|PMID:38127619]" /experiment="EXISTENCE:direct assay:GO:1902485 L-cysteine binding [PMID:38127619]" /experiment="EXISTENCE:direct assay:GO:1904263 positive regulation of TORC1 signaling [PMID:34535752]" /experiment="EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:29698392]" /experiment="EXISTENCE:mutant phenotype:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:29698392]" /experiment="EXISTENCE:mutant phenotype:GO:1902485 L-cysteine binding [PMID:38127619]" /experiment="EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:34535752|PMID:38127619]" /note="Phosphatidylinositol 3-phosphate binding protein; forms a distinct complex with TORC1, induced by glutamine in a dose-dependent manner, resulting in TORC1 activation, suggesting dual roles as both a glutamine sensor and a direct TORC1 activator; functions as a cysteine sensor involved in TORC1 activation; involved in leucine- and glutamine-responsive TORC1 activation, independent of the Gtr/Ego pathway; related to human PLEKHF1; contains a PI3P binding FYVE domain; similar to Fab1p and Vps27p" /db_xref="GeneID:852861" /db_xref="SGD:S000002991" ORIGIN 1 mtalhsvskt paikeeeedg derdgrgvpl gprnhdyrgr kgdeesgadt vtspitfekk 61 kiaprasths eqsilssisl ksmvnqhrqq qlqqesstga gtgfvdrkqq iqspamvsil 121 rknsaeenvr sshssklgeg qidgrkasas keigktlpft ddqrsnpeld ptnsvvdvsr 181 gkntksktvf neleddaddd devrqknltt qalrklssfk mnassnlrls kenkakesss 241 sstssvssss tskvenivdk ltttnsssms qlrfgntnvi idsvnhaakp phqqmlrkps 301 leflpqpass tnlnfnsnkh ksnvrqisnp kkplyipavl rkvsetnitn ddllnatlss 361 yykkasnleh gfnpsksqsa svqnannlri issqssvqsn tssilesykn kissylfpns 421 ipnsdrinli ptisnrnsar vnpptkdhwi pdskrnscry chkpftlwer khhcrhcgdi 481 fcqdhlrhwl yldsqanfim inelnnggin gggtlckicd dclveyenls ttnhnantne 541 dninveeged ddndnrkklr nyyknrqmna lfrpkkggss qehatvdrdt ttpiqvksnd 601 eeadnentgg eqeegndvlg svigsvpanw nwssf // LOCUS NP_011493 718 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011493 VERSION NP_011493.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180887.1 REFERENCE 1 (residues 1 to 718) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 718) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 718) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 718) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 718) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 718) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 718) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 718) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08076. Method: conceptual translation. FEATURES Location/Qualifiers source 1..718 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..718 /product="dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3" /EC_number="2.4.99.18" /calculated_mol_wt="81398" Region 15..475 /region_name="STT3" /note="Oligosaccharyl transferase STT3 subunit; pfam02516" /db_xref="CDD:396873" CDS 1..718 /gene="STT3" /locus_tag="YGL022W" /coded_by="NM_001180887.1:1..2157" /experiment="EXISTENCE:curator inference:GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity [PMID:9405463]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]" /experiment="EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]" /experiment="EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]" /note="Catalytic subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes asparagine-linked glycosylation of newly synthesized proteins in the ER lumen; involved in recognition of N-acetylglucosamine; forms a subcomplex with Ost3p and Ost4p" /db_xref="GeneID:852862" /db_xref="SGD:S000002990" ORIGIN 1 mgsdrscvls vfqtilklvi fvaifgaais srlfavikfe siihefdpwf nyratkylvn 61 nsfykflnwf ddrtwyplgr vtggtlypgl mttsafiwha lrnwlglpid irnvcvlfap 121 lfsgvtawat yeftkeikda sagllaagfi aivpgyisrs vagsydneai aitllmvtfm 181 fwikaqktgs imhatcaalf yfymvsawgg yvfitnlipl hvfllilmgr yssklysayt 241 twyaigtvas mqipfvgflp irsndhmaal gvfgliqiva fgdfvkgqis takfkvimmv 301 slflilvlgv vglsaltymg liapwtgrfy slwdtnyaki hipiiasvse hqpvswpaff 361 fdthfliwlf pagvfllfld lkdehvfvia ysvlcsyfag vmvrlmltlt pvicvsaava 421 lskifdiyld fktsdrkyai kpaallakli vsgsfifyly lfvfhstwvt rtaysspsvv 481 lpsqtpdgkl aliddfreay ywlrmnsded skvaawwdyg yqiggmadrt tlvdnntwnn 541 thiaivgkam aspeeksyei lkehdvdyvl vifggligfg gddinkflwm irisegiwpe 601 eikerdfyta egeyrvdara setmrnslly kmsykdfpql fnggqatdrv rqqmitpldv 661 ppldyfdevf tsenwmvriy qlkkddaqgr tlrdvgeltr sstktrrsik rpelglrv // LOCUS NP_011494 760 aa linear PLN 30-JUN-2025 DEFINITION protein kinase ALK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011494 VERSION NP_011494.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180886.1 REFERENCE 1 (residues 1 to 760) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 760) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 760) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 760) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 760) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08077. Method: conceptual translation. FEATURES Location/Qualifiers source 1..760 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..760 /product="protein kinase ALK1" /EC_number="2.7.11.1" /calculated_mol_wt="85956" Region 211..760 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" CDS 1..760 /gene="ALK1" /locus_tag="YGL021W" /coded_by="NM_001180886.1:1..2283" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16855400]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:33585466]" /experiment="EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:33585466]" /note="Atypical protein kinase; along with paralog, ALK2, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of formins and polarisome components in mitosis, and survival after spindle assembly checkpoint delay; regulates the morphogenesis checkpoint in response to polarity insults through inactivation of Mih1p; phosphorylated in response to DNA damage; similar to mammalian haspins" /db_xref="GeneID:852863" /db_xref="SGD:S000002989" ORIGIN 1 mllhfdiviq llsshtlksh qveppmdfet sfeefvedkr fialevsdnd ddcdtdltad 61 tadelessai lkmresdasl nvttgnntsr kttsnskkrw sllsnhsavs sskskkrwsv 121 lsssftsesh kdresrnvlq qkrkslqsys sldtvasnss isassslkrs stglslrqlf 181 tkiginddis qpgigipqgk enlpptmgkk nssiastsse nrlrtplkpl vnhskrptsq 241 pqqqqplyna slssrrssis stvssssssk wrfwkrnknq tpallqpdhh slktfpavnr 301 rdsmtpvepr nmvkhktsfs dfhktifssn tysessdtis smeitlknka sssslslnvl 361 kkrnsqsslk hksshaslqk fkrnkgkssm iapstatnss nddscsyssk nstlshrisl 421 pvpdqvsrdk iqnklrysts llslnskssl pmnkndhdet llrqillncd ikrilnpakg 481 dvlplindvn hlssiqltsn vwqigevick kvslgtiddi twdrkflslq eleklkimqq 541 kfdgipqllk sfvvkeangg lylyllfkdh gtpislislk nwkqilkifw scagiihgle 601 knlkfehrnl tldnilidgn gnitiidfkc srlqtpqddv lylrldhplf flngkdkski 661 neyqyqfefe iyqsmrilln mdasafepmt nlywlyylsr vllkfgdrkl gkndanrdkm 721 arvinhlemn lavhkrggql fkrletedik ntgdllklyk // LOCUS NP_011495 235 aa linear PLN 30-JUN-2025 DEFINITION GET complex subunit GET1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011495 VERSION NP_011495.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180885.1 REFERENCE 1 (residues 1 to 235) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 235) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 235) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08078. Method: conceptual translation. FEATURES Location/Qualifiers source 1..235 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..235 /product="GET complex subunit GET1" /calculated_mol_wt="26961" Region 7..191 /region_name="CHD5" /note="CHD5-like protein; pfam04420" /db_xref="CDD:427938" CDS 1..235 /gene="GET1" /locus_tag="YGL020C" /gene_synonym="MDM39" /coded_by="NM_001180885.1:1..708" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:36640319]" /experiment="EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:36640319]" /experiment="EXISTENCE:direct assay:GO:0097051 establishment of protein localization to endoplasmic reticulum membrane [PMID:36640319]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]" /experiment="EXISTENCE:genetic interaction:GO:0043495 protein-membrane adaptor activity [PMID:18724936]" /experiment="EXISTENCE:genetic interaction:GO:0071816 tail-anchored membrane protein insertion into ER membrane [PMID:18724936]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:29673596]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:16269340]" /experiment="EXISTENCE:mutant phenotype:GO:0032977 membrane insertase activity [PMID:25043001]" /experiment="EXISTENCE:physical interaction:GO:0043529 GET complex [PMID:16269340]" /note="Subunit of the GET complex; involved in insertion of tail-anchored proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance; Get1p and Get2p form an aqueous channel for protein translocation and insertion into the membrane" /db_xref="GeneID:852864" /db_xref="SGD:S000002988" ORIGIN 1 mhwaaavaif fivvtkflqy tnkyhekwis kfapgnelsk kylakvkerh elkefnnsis 61 aqdnyakwtk nnrkldsldk einnlkdeiq senkafqahl hklrllaltv pffvfkimyg 121 ktpvyklsss tstlfptfvs gvwsqgwlyv llhplrtisq kwhimegkfg askfddmalq 181 svslgiwvwa lmnvingvef ivkqlfltpk meapasvetq eekaldavdd aiild // LOCUS NP_011496 278 aa linear PLN 30-JUN-2025 DEFINITION casein kinase 2 regulatory subunit CKB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011496 VERSION NP_011496.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180884.3 REFERENCE 1 (residues 1 to 278) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 278) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 278) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 278) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08079. On Jul 30, 2012 this sequence version replaced NP_011496.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..278 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..278 /product="casein kinase 2 regulatory subunit CKB1" /calculated_mol_wt="32134" Region 1..278 /region_name="SKB2" /note="Casein kinase II, beta subunit [Signal transduction mechanisms / Cell division and chromosome partitioning / Transcription]; COG5041" /db_xref="CDD:227374" CDS 1..278 /gene="CKB1" /locus_tag="YGL019W" /coded_by="NM_001180884.3:1..837" /experiment="EXISTENCE:direct assay:GO:0005956 protein kinase CK2 complex [PMID:8135547]" /experiment="EXISTENCE:direct assay:GO:0006356 regulation of transcription by RNA polymerase I [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0006359 regulation of transcription by RNA polymerase III [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0006974 DNA damage response [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0019887 protein kinase regulator activity [PMID:8135547]" /experiment="EXISTENCE:direct assay:GO:0030291 protein serine/threonine kinase inhibitor activity [PMID:18265947]" /experiment="EXISTENCE:direct assay:GO:0034456 UTP-C complex [PMID:17515605]" /experiment="EXISTENCE:mutant phenotype:GO:0019887 protein kinase regulator activity [PMID:11827175]" /note="Beta regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases" /db_xref="GeneID:852865" /db_xref="SGD:S000002987" ORIGIN 1 msqefvedys rtgssddeds gaydewipsf csrfgheyfc qvptefiedd fnmtslsqev 61 phyrkaldli ldleamsdee ededdvveed evdqemqsnd ghdegkrrnk spvvnksiie 121 haaeqlygli harfiltkpg lqamaekfdh kefgtcpryy cngmqllpcg lsdtvgkhtv 181 rlycpscqdl ylpqssrflc legafwgtsf pgvflkhfke leeyverksk esyelkvfgf 241 rindeavsgp rmkwlrqyps teedweefak cefetpav // LOCUS NP_011497 184 aa linear PLN 30-JUN-2025 DEFINITION J-type chaperone JAC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011497 VERSION NP_011497.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180883.1 REFERENCE 1 (residues 1 to 184) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 184) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 184) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 184) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08080. Method: conceptual translation. FEATURES Location/Qualifiers source 1..184 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..184 /product="J-type chaperone JAC1" /calculated_mol_wt="21647" Region 29..179 /region_name="hscB" /note="Fe-S protein assembly co-chaperone HscB; TIGR00714" /db_xref="CDD:211601" CDS 1..184 /gene="JAC1" /locus_tag="YGL018C" /coded_by="NM_001180883.1:1..555" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:12756240]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:11278728|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11171977|PMID:11273703]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:11273703]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:11278728]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:9813017]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:11171977]" /experiment="EXISTENCE:mutant phenotype:GO:0044571 [2Fe-2S] cluster assembly [PMID:11273703]" /experiment="EXISTENCE:mutant phenotype:GO:0044572 [4Fe-4S] cluster assembly [PMID:11278728]" /experiment="EXISTENCE:mutant phenotype:GO:0051087 protein-folding chaperone binding [PMID:11278728]" /note="Specialized J-protein that functions in Fe-S cluster biogenesis; functions with Hsp70 in Fe-S cluster biogenesis in mitochondria; involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix" /db_xref="GeneID:852866" /db_xref="SGD:S000002986" ORIGIN 1 mlkylvqrrf tstfyelfpk tfpkklpiwt idqsrlrkey rqlqaqhhpd maqqgseqss 61 tlnqayhtlk dplrrsqyml kllrnidltq eqtsnevtts dpqlllkvld ihdelsqmdd 121 eagvkllekq nkeriqdiea qlgqcyndkd yaaavkltve lkywynlaka fkdwapgkql 181 emnh // LOCUS NP_011498 503 aa linear PLN 30-JUN-2025 DEFINITION arginyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011498 VERSION NP_011498.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180882.1 REFERENCE 1 (residues 1 to 503) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 503) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 503) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 503) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08081. Method: conceptual translation. FEATURES Location/Qualifiers source 1..503 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..503 /product="arginyltransferase" /EC_number="2.3.2.8" /calculated_mol_wt="57800" Region 19..115 /region_name="ATE_N" /note="Arginine-tRNA-protein transferase, N terminus; pfam04376" /db_xref="CDD:461281" Region 165..313 /region_name="ATE_C" /note="Arginine-tRNA-protein transferase, C terminus; pfam04377" /db_xref="CDD:461282" CDS 1..503 /gene="ATE1" /locus_tag="YGL017W" /coded_by="NM_001180882.1:1..1512" /experiment="EXISTENCE:direct assay:GO:0004057 arginyl-tRNA--protein transferase activity [PMID:2185248]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016598 protein arginylation [PMID:2185248]" /experiment="EXISTENCE:mutant phenotype:GO:0004057 arginyl-tRNA--protein transferase activity [PMID:2185248]" /experiment="EXISTENCE:mutant phenotype:GO:0016598 protein arginylation [PMID:2185248]" /note="Arginyl-tRNA-protein transferase; catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway; may have a role in regulating stress response" /db_xref="GeneID:852867" /db_xref="SGD:S000002985" ORIGIN 1 msdrfviwap smhnepaakc gychgnkggn mdqlfaldsw ahrymnkmdv vkienctigs 61 fvehmdvaty drmcnmgfrr sgkflykvdp lrnccrlyti rtapqelnmt kelkkcisrf 121 atritsedyc paavassdfv gkivnaemns ktfytrfepa lyseekyhlf vkyqekvhqd 181 ynnspksfkr flcdtpfgpe avlgtqeswe qlnnwqrmkp geklkhmgpv hecyyyegkl 241 iaitvsdilp sgissvyfiw dpdyskwslg klsalrdlai iqrtnlqyyy lgyyiedcpk 301 mnykanygae vldvchskyi plkpiqdmis rgklfvigee etkvtkelyl vdsetgrgeg 361 fptdnvvkyk niaeeiygvg gcafksanes alelkelygi pyeeedldti yhlkehngha 421 pngipnvvpg llplwelldi mqsgkitdle grlflfeiet egirplinfy seppnvkkri 481 cdvirlfgfe tcmkavilys eqm // LOCUS NP_011499 1081 aa linear PLN 30-JUN-2025 DEFINITION Kap122p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011499 VERSION NP_011499.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180881.1 REFERENCE 1 (residues 1 to 1081) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1081) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1081) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1081) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08082. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1081 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1081 /product="Kap122p" /calculated_mol_wt="123400" CDS 1..1081 /gene="KAP122" /locus_tag="YGL016W" /gene_synonym="PDR6" /coded_by="NM_001180881.1:1..3246" /experiment="EXISTENCE:direct assay:GO:0005049 nuclear export signal receptor activity [PMID:31023724]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:10525531]" /experiment="EXISTENCE:direct assay:GO:0051168 nuclear export [PMID:31023724]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:10525531]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:10525531]" /experiment="EXISTENCE:physical interaction:GO:0061608 nuclear import signal receptor activity [PMID:10525531]" /note="Karyopherin beta; bidirectional nuclear transport receptor (biportin) that shuttles distinct sets of cargoes in opposite directions; responsible for import of Toa1p-Toa2p complex into nucleus; depletes eIF5A and eEF2 from cell nuclei; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance" /db_xref="GeneID:852868" /db_xref="SGD:S000002984" ORIGIN 1 mssihevval ieelysphpk hdvnqiqqsl qsiqkseqgf hlanellsdd kysanvkyfg 61 altltvqlnt rgendyetlw nvfrsnllyl tkfstlyvsn pnmygqslii ikklmsnlsl 121 iftkindpql nnagnenmik qwnnpintfi qlmsvqnqni nadqllldsi ncsltyeqls 181 qfvslsqkhn elaltftevi vedltkfqtk rhsmsqihev vhehlyistm alinlnltaq 241 avfnptvfdc itawinyisl trsvsssgrm dlseifqnli dlmyqstegs dgyenaekil 301 tifgnvfand pllmsydlrq qieciflgvv rpdsgitdis nknswmlqym nylvtndffs 361 elkelaiciv dflqintlsv cnklftniqa adngqvqdey iqeyikvllq mtnfpltpvl 421 qeffsvrmvd fwldlsdayt nlasetlrpn sielstqifq qliniylpki slsvkqriie 481 eegestsvne fedfrnavsd laqslwsilg ndnltnvlid gmgqmpaasd etliikdtdv 541 lfrietmcfv lntilvdmtl sespwikniv dankffnqnv isvfqtgfqt sastkvsqil 601 kldfvrtstt ligtlagyfk qepfqlnpyv ealfqglhtc tnftskneqe kisndklevm 661 viktvstlce tcreeltpyl mhfisflntv impdsnvshf trtklvrsig yvvqcqvsng 721 peeqakyilq ltnllsgsie hclassvqlq eqqdyincll yciselatsl iqpteiiend 781 allqrlsefq sfwssdplqi rskimctidk vldnsiyckn safveigcli vgkglnlpdg 841 epyflkynms evmnfvlrhv pncelatclp yfvyllekli sefrkeltpq efdfmfekil 901 lvyydayiin dpdllqmtig fvnnvldvkp glaigskhwt sfilpqflkl ipsrekftiv 961 avakfwtkli nnkkynqeel ttvrqqvssi ggdlvyqimy glfhtqrsdl nsytdllral 1021 vakfpieare wlvavlpqic nnpaghekfi nkllitrgsr aagnvilqww ldcttlpnyq 1081 g // LOCUS NP_011500 130 aa linear PLN 30-JUN-2025 DEFINITION Bil2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011500 VERSION NP_011500.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180880.3 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08083. On Jul 30, 2012 this sequence version replaced NP_011500.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..130 /product="Bil2p" /calculated_mol_wt="14830" CDS 1..130 /gene="BIL2" /locus_tag="YGL015C" /coded_by="NM_001180880.3:1..393" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:38656798|PMID:33634134]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:33634134]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:38656798]" /experiment="EXISTENCE:direct assay:GO:0090339 negative regulation of formin-nucleated actin cable assembly [PMID:33634134]" /experiment="EXISTENCE:direct assay:GO:0099503 secretory vesicle [PMID:33634134]" /experiment="EXISTENCE:mutant phenotype:GO:0031382 mating projection formation [PMID:38656798]" /experiment="EXISTENCE:mutant phenotype:GO:0070649 formin-nucleated actin cable assembly [PMID:38656798]" /experiment="EXISTENCE:mutant phenotype:GO:1903260 protein localization to mating projection tip [PMID:38656798]" /note="Formin inhibitor; inhibits Bnr1p-mediated actin filament nucleation but not elongation during vegetative growth; performs distinct but overlapping roles with Hof1p to control actin cable assembly and polarized secretion; spatially focuses Bni1p at mating projection tips, and with Bud6p organizes Bni1p into clusters that nucleate actin assembly during mating projection formation; bnr1 bil2 double mutants are inviable; localizes to the cytosol, secretory vesicles and sites of polarized growth" /db_xref="GeneID:852869" /db_xref="SGD:S000002983" ORIGIN 1 medtirplny adietsgpin llettnnlks slkkfsqkak gshisrerih hfrkwknkte 61 slsenhlkpp pdvdslcfsn cfqpdalsgn vflpprssnm ywnekqlqle meilkflsln 121 tsnecctsdd // LOCUS NP_011501 888 aa linear PLN 30-JUN-2025 DEFINITION Puf4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011501 VERSION NP_011501.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180879.1 REFERENCE 1 (residues 1 to 888) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 888) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 888) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 888) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08084. Method: conceptual translation. FEATURES Location/Qualifiers source 1..888 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..888 /product="Puf4p" /calculated_mol_wt="97667" Region 65..888 /region_name="COG5099" /note="RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]" /db_xref="CDD:227430" CDS 1..888 /gene="PUF4" /locus_tag="YGL014W" /gene_synonym="YGL023" /coded_by="NM_001180879.1:1..2667" /experiment="EXISTENCE:direct assay:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:17389596]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:18327269|PMID:23222640|PMID:15024427]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:20427513]" /experiment="EXISTENCE:genetic interaction:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11101532]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:9150138]" /note="Member of the PUF protein family; PUF family is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors" /db_xref="GeneID:852870" /db_xref="SGD:S000002982" ORIGIN 1 mstkglkeei ddvpsvdpvv setvnsaleq lqlddpeena tsnafankvs qdsqfangpp 61 sqmfphpqmm ggmgfmpysq mmqvphnpcp ffpppdfndp taplssspln aggppmlfkn 121 dslpfqmlss gaavatqggq nlnplindns mkvlpiasad plwthsnvpg sasvaieett 181 atlqeslpsk gresnnkass frrqtfhals ptdlinaann vtlskdfqsd mqnfskakkp 241 svganntakt rtqsisfdnt psstsfippt nsvseklsdf kietskedli nktapakkes 301 pttygaaypy ggpllqpnpi mpghphniss piygirspfp nsyemgaqfq pfspilnpts 361 hslnanspip ltqspihlap vlnpssnsva fsdmkndggk pttdndkagp nvrmdlinpn 421 lgpsmqpfhi lppqqntppp pwlystpppf namvpphlla qnhmplmnsa nnkhhgrnnn 481 smsshndndn ignsnynnkd tgrsnvgkmk nmknsyhgyy nnnnnnnnnn nnnnnsnatn 541 snsaekqrki eessrfadav ldqyigsihs lckdqhgcrf lqkqldilgs kaadaifeet 601 kdytvelmtd sfgnyliqkl leevtteqri vltkissphf veislnphgt ralqklieci 661 ktdeeaqivv dslrpytvql skdlngnhvi qkclqrlkpe nfqfifdais dscidiathr 721 hgccvlqrcl dhgtteqcdn lcdkllalvd kltldpfgny vvqyiitkea eknkydythk 781 ivhllkprai elsihkfgsn viekilktai vsepmileil nnggetgiqs llndsygnyv 841 lqtaldishk qndylykrls eivapllvgp irntphgkri igmlhlds // LOCUS NP_011502 1068 aa linear PLN 30-JUN-2025 DEFINITION drug-responsive transcription factor PDR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011502 VERSION NP_011502.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180878.1 REFERENCE 1 (residues 1 to 1068) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1068) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1068) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1068) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1068) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1068) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1068) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1068) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08085. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1068 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1068 /product="drug-responsive transcription factor PDR1" /calculated_mol_wt="121663" Region 40..77 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(41,45,50..53,55,58,67) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(46,49,56,62,65,72) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 418..637 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..1068 /gene="PDR1" /locus_tag="YGL013C" /gene_synonym="AMY1; ANT1; BOR2; CYH3; NRA2; SMR2; TIL1; TPE1; TPE3" /coded_by="NM_001180878.1:1..3207" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11136452|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:genetic interaction:GO:2001040 positive regulation of cellular response to drug [PMID:8078477]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9428726|PMID:8798494]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9428726|PMID:8798494]" /experiment="EXISTENCE:mutant phenotype:GO:0071466 cellular response to xenobiotic stimulus [PMID:9428726|PMID:8798494]" /experiment="EXISTENCE:mutant phenotype:GO:2001040 positive regulation of cellular response to drug [PMID:9767597|PMID:15713640]" /note="Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; relocalizes to the cytosol in response to hypoxia; PDR1 has a paralog, PDR3, that arose from the whole genome duplication" /db_xref="GeneID:852871" /db_xref="SGD:S000002981" ORIGIN 1 mrgltpkngv hietgpdtes sadssnfstg fsgkirkprs kvskacdncr krkikcngkf 61 pcasceiysc ectfstrqgg ariknlhkts legttvqvke etdssstsfs npqrctdgpc 121 aveqptkffe nfklggrssg dnsgsdgknd ddvnrngfye ddsesqatlt slqttlknlk 181 emahlgthvt saiesielqi sdllkrwepk vrtkelattk fypnksietq lmknkycdvv 241 hltryaawsn nkkdqdtssq plideifgly spfqflslqg igkcfqnyrs kskceifprt 301 aketiyimlr ffdvcfhhin qgcvsianpl enylqkmnll pstpssissa gspntahtks 361 hvalvinhlp qpfvrnitgi snsellsemn ndismfgill kmldmhknsy qnflmeitsn 421 psvakntqsi dvlqefihyc qagealialc ysyynstlyn yvdftcdith leqllyfldl 481 lfwlseiygf ekvlnvavhf vsrvglsrwe fyvgldenfa errrnlwwka fyfektlask 541 lgypsnidds kincllpknf rdvgfldnrd fienvhlvrr seafdnmcis dlkyygelav 601 lqivshfsss vlfnekftsi rntskpsvvr ekllfevlei fnetemkyda ikeqtgklfd 661 iafskdstel kvsredkima skfvlfyehh fcrmvnesdn ivarlcvhrr psilienlki 721 ylhkiykswt dmnkilldfd ndysvyrsfa hysisciilv sqafsvaefi kvndvvnmir 781 vfkrfldiki fsenetnehv fnsqsfkdyt rafsfltivt rimllayges sstnldvisk 841 yidenapdlk giielvldtn scayrfllep vqksgfhltv sqmlknrkfq eplmsnednk 901 qmkhnsgknl npdlpslktg tscllngies pqlpfngrsa pspvrnnslp efaqlpsfrs 961 lsvsdminpd yaqptngqnn tqvqsnkpin aqqqiptsvq vpfmntnein nnnnnnnnnk 1021 nninninnnn snnfsatsfn lgtldefvnn gdledlysil wsdvypds // LOCUS NP_011503 473 aa linear PLN 30-JUN-2025 DEFINITION delta(24(24(1)))-sterol reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011503 VERSION NP_011503.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180877.1 REFERENCE 1 (residues 1 to 473) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 473) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 473) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 473) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08086. Method: conceptual translation. FEATURES Location/Qualifiers source 1..473 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..473 /product="delta(24(24(1)))-sterol reductase" /EC_number="1.3.1.71" /calculated_mol_wt="55909" Region 34..473 /region_name="ERG4_ERG24" /note="Ergosterol biosynthesis ERG4/ERG24 family; pfam01222" /db_xref="CDD:250456" CDS 1..473 /gene="ERG4" /locus_tag="YGL012W" /coded_by="NM_001180877.1:1..1422" /experiment="EXISTENCE:direct assay:GO:0000246 Delta24(24-1) sterol reductase activity [PMID:14922]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:10722850]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10722850]" /experiment="EXISTENCE:direct assay:GO:0050614 Delta24-sterol reductase activity [PMID:10722850]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:8125337]" /note="C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol" /db_xref="GeneID:852872" /db_xref="SGD:S000002980" ORIGIN 1 makdnseklq vqgeekkskq pvnflpqgkw lkpneieyef ggttgvigml igfpllmyym 61 wicaefyhgk valpkagesw mhfikhlyql vlengipeky dwtifltfwv fqiifyytlp 121 giwtkgqpls hlkgkqlpyf cnamwtlyvt ttlvlvlhft nlfrlyviid rfgrimtcai 181 isgfafsiil ylwtlfishd yhrmtgnhly dffmgaplnp rwgildlkmf fevrlpwftl 241 yfitlgaclk qwetygyvtp qlgvvmlahw lyanacakge elivptwdma yekfgfmlif 301 wniagvpyty chctlylyyh dpseyhwstl ynvslyvvll cayyffdtan aqknafrkqm 361 sgdktgrktf pflpyqilkn pkymvtsngs yllidgwytl arkihytadw tqslvwalsc 421 gfnsvfpwff pvfflvvlih rafrdqakck rkygkdwdey ckhcpyvfip yvf // LOCUS NP_011504 252 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit alpha 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011504 VERSION NP_011504.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180876.3 REFERENCE 1 (residues 1 to 252) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 252) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 252) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 252) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08087. On Jul 30, 2012 this sequence version replaced NP_011504.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..252 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..252 /product="proteasome core particle subunit alpha 1" /calculated_mol_wt="27870" Region 12..228 /region_name="proteasome_alpha_type_6" /note="The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming...; cd03754" /db_xref="CDD:239723" Site order(14..17,19..20,22..23,27,30,33..34,37,46,61,63..64, 87..89,91..92,123,126,129..130,133..137,155,160..161,163, 165..166,168) /site_type="other" /note="alpha subunit interaction site [polypeptide binding]" /db_xref="CDD:239723" Site order(40,56,58,71,173) /site_type="active" /db_xref="CDD:239723" CDS 1..252 /gene="SCL1" /locus_tag="YGL011C" /gene_synonym="PRC2" /coded_by="NM_001180876.3:1..759" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019773 proteasome core complex, alpha-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /note="Alpha 1 subunit of the 20S proteasome; involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria" /db_xref="GeneID:852873" /db_xref="SGD:S000002979" ORIGIN 1 msgaaaasaa gydrhitifs pegrlyqvey afkatnqtni nslavrgkdc tvvisqkkvp 61 dklldpttvs yifcisrtig mvvngpipda rnaalrakae aaefrykygy dmpcdvlakr 121 manlsqiytq raymrplgvi ltfvsvdeel gpsiyktdpa gyyvgykata tgpkqqeitt 181 nlenhfkksk idhineeswe kvvefaithm idalgtefsk ndlevgvatk dkfftlsaen 241 ieerlvaiae qd // LOCUS NP_011505 174 aa linear PLN 30-JUN-2025 DEFINITION 2-hydroxy-palmitic acid dioxygenase MPO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011505 VERSION NP_011505.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180875.1 REFERENCE 1 (residues 1 to 174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 174) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08088. Method: conceptual translation. FEATURES Location/Qualifiers source 1..174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..174 /product="2-hydroxy-palmitic acid dioxygenase MPO1" /EC_number="1.14.18.12" /calculated_mol_wt="20042" Region 7..148 /region_name="Mpo1-like" /note="2-hydroxy-palmitic acid dioxygenase Mpo1-like; pfam06127" /db_xref="CDD:377609" CDS 1..174 /gene="MPO1" /locus_tag="YGL010W" /coded_by="NM_001180875.1:1..525" /experiment="EXISTENCE:direct assay:GO:0001561 fatty acid alpha-oxidation [PMID:30530523]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0102672 fatty acid alpha-dioxygenase activity [PMID:30530523]" /experiment="EXISTENCE:mutant phenotype:GO:0046521 sphingoid catabolic process [PMID:25345524]" /note="Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids; involved in metabolism of phytosphingosine; not an essential gene" /db_xref="GeneID:852874" /db_xref="SGD:S000002978" ORIGIN 1 mgeglldlrs qlgfykfyhh npknvlihsi fvptilfsgs cmlhrvkiyq sisltavlsv 61 lfsifyclly lptgllagvl llllnlalid hrvdltfkqe lglftigwif qfvghgvfek 121 rrpalidnlv qslvlapyfi mfeflfklgf mprlkatleh dleikqrnlr mqrq // LOCUS NP_011506 779 aa linear PLN 30-JUN-2025 DEFINITION 3-isopropylmalate dehydratase LEU1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011506 VERSION NP_011506.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180874.1 REFERENCE 1 (residues 1 to 779) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 779) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 779) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 779) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08089. Method: conceptual translation. FEATURES Location/Qualifiers source 1..779 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..779 /product="3-isopropylmalate dehydratase LEU1" /EC_number="4.2.1.33" /calculated_mol_wt="85664" Region 9..480 /region_name="PRK05478" /note="3-isopropylmalate dehydratase large subunit" /db_xref="CDD:235490" Site order(40,43,141..142,425,444,449) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:153133" Site order(143,360,421,424..425,443) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:153133" Region 545..736 /region_name="leuD" /note="3-isopropylmalate dehydratase, small subunit; TIGR00171" /db_xref="CDD:129275" Site 629..631 /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238809" CDS 1..779 /gene="LEU1" /locus_tag="YGL009C" /coded_by="NM_001180874.1:1..2340" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:4355481]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0003861 3-isopropylmalate dehydratase activity [PMID:5724969]" /experiment="EXISTENCE:mutant phenotype:GO:0009098 L-leucine biosynthetic process [PMID:6323436|PMID:5724969]" /note="Isopropylmalate isomerase; catalyzes the second step in the leucine biosynthesis pathway" /db_xref="GeneID:852875" /db_xref="SGD:S000002977" ORIGIN 1 mvytpskgpr tlydkvfdah vvhqdengsf llyidrhlvh evtspqafeg lenagrkvrr 61 vdctlatvdh niptesrknf ksldtfikqt dsrlqvktle nnvkqfgvpy fgmsdarqgi 121 vhtigpeegf tlpgttvvcg dshtsthgaf gslafgigts evehvlatqt iiqaksknmr 181 itvngklspg itskdlilyi igligtaggt gcviefagea iealsmearm smcnmaieag 241 aragmikpde ttfqytkgrp lapkgaewek avaywktlkt degakfdhei nieavdvipt 301 itwgtspqda lpitgsvpdp knvtdpikks gmeralaymg lepntplksi kvdkvfigsc 361 tngriedlrs aaavvrgqkl asniklamvv pgsglvkkqa eaegldkifq eagfewreag 421 csiclgmnpd ildayercas tsnrnfegrq galsrthlms pamaaaagia ghfvdirefe 481 ykdqdqsspk vevtsedeke lesaaydhae pvqpedapqd iandelkdip vksddtpakp 541 sssgmkpflt legisapldk anvdtdaiip kqflktikrt glkkglfyew rfrkddqgkd 601 qetdfvlnve pwreaeilvv tgdnfgcgss rehapwalkd fgiksiiaps ygdifynnsf 661 kngllpirld qqiiidklip iankggklcv dlpnqkilds dgnvlvdhfe iepfrkhclv 721 nglddigitl qkeeyisrye alrrekysfl eggskllkfd nvpkrkavtt tfdkvhqdw // LOCUS NP_011507 918 aa linear PLN 30-JUN-2025 DEFINITION H(+)-exporting P2-type ATPase PMA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011507 VERSION NP_011507.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180873.1 REFERENCE 1 (residues 1 to 918) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 918) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 918) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 918) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08090. Method: conceptual translation. FEATURES Location/Qualifiers source 1..918 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..918 /product="H(+)-exporting P2-type ATPase PMA1" /EC_number="7.1.2.1" /calculated_mol_wt="99489" Region 87..874 /region_name="P-type_ATPase_H" /note="plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; cd02076" /db_xref="CDD:319771" Site order(378..380,422..423,451,456,458,474..475,511..512, 557..560,609,615,634,637) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:319771" Site order(694..695,699,701,730,803) /site_type="other" /note="proton binding site [ion binding]" /db_xref="CDD:319771" CDS 1..918 /gene="PMA1" /locus_tag="YGL008C" /gene_synonym="KTI10" /coded_by="NM_001180873.1:1..2757" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340|PMID:16622836|PMID:11739806]" /experiment="EXISTENCE:direct assay:GO:0008553 P-type proton-exporting transporter activity [PMID:17912695]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:15536122]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:10716729]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:8396147]" /experiment="EXISTENCE:direct assay:GO:1902600 proton transmembrane transport [PMID:8396147]" /experiment="EXISTENCE:mutant phenotype:GO:1902906 proteasome storage granule assembly [PMID:23690178]" /experiment="EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:29570051]" /note="Plasma membrane P2-type H+-ATPase; pumps protons out of cell; major regulator of cytoplasmic pH and plasma membrane potential; long-lived hexameric protein asymmetrically distributed at plasma membrane between mother cells and buds; accumulates at high levels in mother cells during aging, buds emerge with very low levels of Pma1p, newborn cells have low levels of Pma1p; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]" /db_xref="GeneID:852876" /db_xref="SGD:S000002976" ORIGIN 1 mtdtssssss ssassvsahq ptqekpakty ddaasessdd ddidalieel qsnhgvdded 61 sdndgpvaag earpvpeeyl qtdpsyglts devlkrrkky glnqmadeke slvvkfvmff 121 vgpiqfvmea aailaaglsd wvdfgvicgl lmlnagvgfv qefqagsivd elkktlanta 181 vvirdgqlve ipanevvpgd ilqledgtvi ptdgrivted cflqidqsai tgeslavdkh 241 ygdqtfssst vkrgegfmvv tatgdntfvg raaalvnkaa ggqghftevl ngigiillvl 301 viatlllvwt acfyrtngiv rilrytlgit iigvpvglpa vvtttmavga aylakkqaiv 361 qklsaiesla gveilcsdkt gtltknklsl hepytvegvs pddlmltacl aasrkkkgld 421 aidkaflksl kqypkakdal tkykvlefhp fdpvskkvta vvespegeri vcvkgaplfv 481 lktveedhpi pedvhenyen kvaelasrgf ralgvarkrg eghweilgvm pcmdpprddt 541 aqtvsearhl glrvkmltgd avgiaketcr qlglgtniyn aerlglgggg dmpgseladf 601 venadgfaev fpqhkyrvve ilqnrgylva mtgdgvndap slkkadtgia vegatdaars 661 aadivflapg lsaiidalkt srqifhrmys yvvyrialsl hleiflglwi aildnsldid 721 livfiaifad vatlaiaydn apyspkpvkw nlprlwgmsi ilgivlaigs witlttmflp 781 kggiiqnfga mngimflqis ltenwlifit raagpfwssi pswqlagavf avdiiatmft 841 lfgwwsenwt divtvvrvwi wsigifcvlg gfyyemstse afdrlmngkp mkekkstrsv 901 edfmaamqrv stqheket // LOCUS NP_878075 28 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL007C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878075 VERSION NP_878075.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184592.3 REFERENCE 1 (residues 1 to 28) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 28) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 28) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 28) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08091. On Jul 30, 2012 this sequence version replaced NP_878075.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..28 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..28 /product="uncharacterized protein" /calculated_mol_wt="3038" CDS 1..28 /locus_tag="YGL007C-A" /coded_by="NM_001184592.3:1..87" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding" /db_xref="GeneID:1466455" /db_xref="SGD:S000028632" ORIGIN 1 mlpsisfdyi krpnivlfsn vlslssni // LOCUS NP_001335779 125 aa linear PLN 30-JUN-2025 DEFINITION Brp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335779 VERSION NP_001335779.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348838.1 REFERENCE 1 (residues 1 to 125) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 125) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 125) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 125) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80299. Method: conceptual translation. FEATURES Location/Qualifiers source 1..125 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..125 /product="Brp1p" /calculated_mol_wt="13659" CDS 1..125 /gene="BRP1" /locus_tag="YGL007W" /coded_by="NM_001348838.1:1..378" /note="hypothetical protein; located in the upstream region of PMA1; conserved among S. cerevisiae strains; mediates the cycloheximide-induced degradation of ubiquitinated Agp2p, a regulator of high affinity polyamine and carnitine transport; null mutant is polyamine resistant due to downregulation of PMA1" /db_xref="GeneID:852877" /db_xref="SGD:S000002975" ORIGIN 1 mmekegkkpe rhmdnilkms ipvksmsevs rpgsaalgnt damraslrns rrsfsghvrl 61 vlrlvygfis aviiagsplr drvcfqitgk gqakqsdvwv ipampvyvsp fqeacfvfsp 121 samvt // LOCUS NP_878076 36 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGL006W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878076 VERSION NP_878076.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184634.1 REFERENCE 1 (residues 1 to 36) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 36) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 36) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 36) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08092. Method: conceptual translation. FEATURES Location/Qualifiers source 1..36 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..36 /product="uncharacterized protein" /calculated_mol_wt="4078" CDS 1..36 /locus_tag="YGL006W-A" /coded_by="NM_001184634.1:1..111" /note="hypothetical protein; identified by SAGE" /db_xref="GeneID:1466456" /db_xref="SGD:S000028769" ORIGIN 1 mlifiihyhr hlalhlmgaf qkhsnsispp prkgfi // LOCUS NP_011509 1173 aa linear PLN 30-JUN-2025 DEFINITION calcium-transporting ATPase PMC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011509 VERSION NP_011509.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180871.1 REFERENCE 1 (residues 1 to 1173) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1173) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1173) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1173) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08093. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1173 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1173 /product="calcium-transporting ATPase PMC1" /EC_number="7.2.2.10" /calculated_mol_wt="130731" Region 15..1123 /region_name="ATPase-IIB_Ca" /note="plasma-membrane calcium-translocating P-type ATPase; TIGR01517" /db_xref="CDD:273668" CDS 1..1173 /gene="PMC1" /locus_tag="YGL006W" /coded_by="NM_001180871.1:1..3522" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:24124599|PMID:7507493]" /experiment="EXISTENCE:genetic interaction:GO:0005388 P-type calcium transporter activity [PMID:7507493]" /experiment="EXISTENCE:mutant phenotype:GO:0005388 P-type calcium transporter activity [PMID:10431803]" /experiment="EXISTENCE:mutant phenotype:GO:0006816 calcium ion transport [PMID:7507493|PMID:15280017]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:7507493]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:7507493]" /note="Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in presence of elevated concentrations of calcium; targeted to vacuole via AP-3 pathway; similar to mammalian PMCA1a" /db_xref="GeneID:852878" /db_xref="SGD:S000002974" ORIGIN 1 msrqdensal lannennkps ytgnengvyd nfklsksqls dlhnpksirs fvrlfgyesn 61 slfkylktdk nagislpeis nyrktnrykn ygdnslperi pksflqlvwa afndktmqll 121 tvaavvsfvl glyelwmqpp qydpegnkik qvdwiegvai miavfvvvlv saandyqkel 181 qfaklnkkke nrkiivirnd qeilisihhv lvgdvislqt gdvvpadcvm isgkceades 241 sitgesntiq kfpvdnslrd fkkfnsidsh nhskpldigd vnedgnkiad cmlisgsril 301 sglgrgvits vginsvygqt mtslnaepes tplqlhlsql adnisvygcv saiilflvlf 361 trylfyiipe dgrfhdldpa qkgskfmnif itsitvivva vpeglplavt lalafattrm 421 tkdgnlvrvl rscetmgsat avcsdktgtl tenvmtvvrg fpgnskfdds kslpvseqrk 481 lnskkvfeen cssslrndll anivlnstaf enrdykkndk ntngsknmsk nlsfldkcks 541 rlsffkkgnr eddedqlfkn vnkgrqepfi gsktetalls larlslglqp gelqylrdqp 601 mekfniekvv qtipfessrk waglvvkyke gknkkpfyrf fikgaaeivs kncsykrnsd 661 dtleeinedn kketddeikn lasdalrais vahkdfcecd swppeqlrdk dspniaaldl 721 lfnsqkglil dgllgiqdpl ragvresvqq cqragvtvrm vtgdniltak aiarncails 781 tdisseaysa megtefrklt kneririlpn lrvlarsspe dkrllvetlk gmgdvvavtg 841 dgtndapalk ladvgfsmgi sgtevareas diilmtddfs aivnaikwgr cvsvsikkfi 901 qfqlivnita viltfvssva ssdetsvlta vqllwinlim dtlaalalat dkpdpnimdr 961 kprgrstsli svstwkmils qatlqlivtf ilhfygpelf fkkhedeits hqqqqlnamt 1021 fntfvwlqff tmlvsrklde gdgisnwrgr isaanlnffq dlgrnyyflt imaiigscqv 1081 limffggapf siarqtksmw itavlcgmls limgvlvric pdevavkvfp aafvqrfkyv 1141 fgleflrknh tgkhddeeal leesdspest afy // LOCUS NP_011510 279 aa linear PLN 30-JUN-2025 DEFINITION Golgi transport complex subunit COG7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011510 VERSION NP_011510.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180870.1 REFERENCE 1 (residues 1 to 279) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 279) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 279) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 279) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08094. Method: conceptual translation. FEATURES Location/Qualifiers source 1..279 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..279 /product="Golgi transport complex subunit COG7" /calculated_mol_wt="31644" CDS 1..279 /gene="COG7" /locus_tag="YGL005C" /gene_synonym="COD5" /coded_by="NM_001180870.1:1..840" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /note="Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" /db_xref="GeneID:852879" /db_xref="SGD:S000002973" ORIGIN 1 mveltitgdd ddilsmffde efvphafvdi llsnalnedq iqtqsvssll ltrldfytkn 61 ltkelestiw nldklsqtlp rtwassryhk eaeqndssly steslksskl eyyldtlasa 121 vraletgmhn vteklsdldn ennrntnvrq qlqslmlike riekvvyyle qvrtvtnist 181 vrennttstg tdlsitdfrt slkaledtid eslssaidne akdetnkdli gridslselk 241 clfkgldkff aeysnfsesi kskaqsylst kniddgmis // LOCUS NP_011511 417 aa linear PLN 30-JUN-2025 DEFINITION Rpn14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011511 VERSION NP_011511.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180869.3 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08095. On Jul 30, 2012 this sequence version replaced NP_011511.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..417 /product="Rpn14p" /calculated_mol_wt="46252" Region 96..133 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 133..>357 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 140..176 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 181..217 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 227..283 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 290..328 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 335..378 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 385..412 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..417 /gene="RPN14" /locus_tag="YGL004C" /coded_by="NM_001180869.3:1..1254" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19446323]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:19446323]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:19412159]" /experiment="EXISTENCE:genetic interaction:GO:0070682 proteasome regulatory particle assembly [PMID:19446323|PMID:19446322|PMID:19412159]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:17499717]" /experiment="EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19446323]" /note="Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p" /db_xref="GeneID:852880" /db_xref="SGD:S000002972" ORIGIN 1 mtktitvahi qydfkavlee ndenddefyi nvdknlneik ehkivvlgns rgvdagkgnt 61 fekvgshlyk arldghdflf ntiirdgskm lkradytavd taklqmrrfi lgttegdikv 121 ldsnfnlqre idqahvseit klkffpsgea lisssqdmql kiwsvkdgsn prtlighrat 181 vtdiaiidrg rnvlsasldg tirlwecgtg ttihtfnrke nphdgvnsia lfvgtdrqlh 241 eistskknnl efgtygkyvi aghvsgvitv hnvfskeqti qlpskftcsc nsltvdgnna 301 nyiyagyeng mlaqwdlrsp ecpvgeflin egtpinnvyf aagalfvssg fdtsikldii 361 sdpeserpai efetptflvs nddevsqfcy vsddesngev levgknnfca lynlsnp // LOCUS NP_011512 566 aa linear PLN 30-JUN-2025 DEFINITION Cdh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011512 VERSION NP_011512.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180868.1 REFERENCE 1 (residues 1 to 566) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 566) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 566) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 566) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08096. Method: conceptual translation. FEATURES Location/Qualifiers source 1..566 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..566 /product="Cdh1p" /calculated_mol_wt="62691" Region 269..543 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 269..300 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Site order(279,288..289,300..301,319,323,329..330,342..343,358, 363,369..370,384,401,406,412..413,425..426,444,451, 457..458,470,488,494,500..501,513..514,532,536,542..543) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 305..342 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 348..383 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 388..424 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 431..467 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 474..512 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 518..544 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..566 /gene="CDH1" /locus_tag="YGL003C" /gene_synonym="HCT1" /coded_by="NM_001180868.1:1..1701" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12456658]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12456658]" /experiment="EXISTENCE:direct assay:GO:0030332 cyclin binding [PMID:11566880]" /experiment="EXISTENCE:direct assay:GO:0045732 positive regulation of protein catabolic process [PMID:17178718]" /experiment="EXISTENCE:direct assay:GO:1990757 ubiquitin ligase activator activity [PMID:15060174|PMID:19362536]" /experiment="EXISTENCE:direct assay:GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process [PMID:18172166]" /experiment="EXISTENCE:genetic interaction:GO:0010697 negative regulation of mitotic spindle pole body separation [PMID:16688214]" /experiment="EXISTENCE:genetic interaction:GO:1903473 positive regulation of mitotic actomyosin contractile ring contraction [PMID:19109423]" /experiment="EXISTENCE:genetic interaction:GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process [PMID:9334304]" /experiment="EXISTENCE:mutant phenotype:GO:0010697 negative regulation of mitotic spindle pole body separation [PMID:16688214]" /experiment="EXISTENCE:mutant phenotype:GO:0045842 positive regulation of mitotic metaphase/anaphase transition [PMID:9831566]" /experiment="EXISTENCE:mutant phenotype:GO:1902426 deactivation of mitotic spindle assembly checkpoint [PMID:25025567]" /experiment="EXISTENCE:mutant phenotype:GO:1903473 positive regulation of mitotic actomyosin contractile ring contraction [PMID:19109423]" /experiment="EXISTENCE:mutant phenotype:GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process [PMID:9334304]" /experiment="EXISTENCE:physical interaction:GO:0005680 anaphase-promoting complex [PMID:9831566]" /note="Activator of anaphase-promoting complex/cyclosome (APC/C); antagonist of the spindle assembly checkpoint; directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including: Cdc20p, Ase1p, Cin8p, Fin1p and Clb5p; partially active in metaphase, and fully active in anaphase; cell-cycle regulated" /db_xref="GeneID:852881" /db_xref="SGD:S000002971" ORIGIN 1 mstnlnpfmn ntpsssplkg seskrvskrp isssssasll sspsrrsrps tvygdryips 61 rtdidfnsiv sissmasvpa lnpsstedqv eyqkerqahe tyntllknel fgemlskdtv 121 gsessidrik ntrpstrgnv haenttrhgy elervstppp eaagleefsp hstpvtprrl 181 ftsqqdeitr pssnsvrgas lltyqqrkgr rlsaasllqs qffdsmspvr pdskqlllsp 241 gkqfrqiakv pyrvldapsl addfyyslid wsstdvlava lgksifltdn ntgdvvhlcd 301 teneytslsw igagshlavg qanglveiyd vmkrkcirtl sghidrvacl swnnhvltsg 361 srdhrilhrd vrmpdpffet ieshtqevcg lkwnvadnkl asggndnvvh vyegtskspi 421 ltfdehkaav kamawsphkr gvlatgggta drrlkiwnvn tsikmsdids gsqicnmvws 481 kntnelvtsh gyskynltlw dcnsmdpiai lkghsfrvlh ltlsndgttv vsgagdetlr 541 ywklfdkpka kvqpnslifd afnqir // LOCUS NP_011513 216 aa linear PLN 30-JUN-2025 DEFINITION Erp6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011513 VERSION NP_011513.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180867.1 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08097. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..216 /product="Erp6p" /calculated_mol_wt="25144" Region 19..210 /region_name="EMP24_GP25L" /note="emp24/gp25L/p24 family/GOLD; pfam01105" /db_xref="CDD:426051" CDS 1..216 /gene="ERP6" /locus_tag="YGL002W" /coded_by="NM_001180867.1:1..651" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10359606]" /note="Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication" /db_xref="GeneID:852882" /db_xref="SGD:S000002970" ORIGIN 1 mlshyiflaf vllpfrvsaf yfygyggdrk cflkelskdt llkgsynlev yddkladyal 61 psyndygivi dveevfdnnh rvvhqqgsps gdfsflales geykiclqsr vnnwvgktkt 121 kleiefevgf eamldmqrke tleslhgkvs ilnskivdir reqqlmrere esfrdisesv 181 nsramwwtvt qvtlliiicv wqmkslrsff vkqkvl // LOCUS NP_011514 349 aa linear PLN 30-JUN-2025 DEFINITION sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) [Saccharomyces cerevisiae S288C]. ACCESSION NP_011514 VERSION NP_011514.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180866.1 REFERENCE 1 (residues 1 to 349) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 349) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 349) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 349) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08098. Method: conceptual translation. FEATURES Location/Qualifiers source 1..349 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..349 /product="sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating)" /EC_number="1.1.1.170" /calculated_mol_wt="38575" Region 6..345 /region_name="3b-HSD-NSDHL-like_SDR_e" /note="human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs; cd09813" /db_xref="CDD:187673" Site order(11,13..16,37..39,84..86,99,122..124,151,155,179..182) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:187673" Site order(100,124,151,155) /site_type="active" /db_xref="CDD:187673" Site order(124,151,181,194,205,210) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:187673" CDS 1..349 /gene="ERG26" /locus_tag="YGL001C" /coded_by="NM_001180866.1:1..1050" /experiment="EXISTENCE:direct assay:GO:0000252 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity [PMID:9811880]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12119386|PMID:26928762|PMID:11279045]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12119386]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:9811880]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:9811880]" /experiment="EXISTENCE:mutant phenotype:GO:0102175 3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity [PMID:9811880]" /note="C-3 sterol dehydrogenase; catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; human homolog NSDHL implicated in CK syndrome, and can complement yeast null mutant; molecular target of natural product and antifungal compound FR171456" /db_xref="GeneID:852883" /db_xref="SGD:S000002969" ORIGIN 1 mskidsvlii ggsgflglhl iqqffdinpk pdihifdvrd lpeklskqft fnvddikfhk 61 gdltspddme naineskanv vvhcaspmhg qnpdiydivn vkgtrnvidm ckkcgvnilv 121 ytssagvifn gqdvhnadet wpipevpmda ynetkaiaed mvlkandpss dfytvalrpa 181 gifgpgdrql vpglrqvakl gqskfqigdn nnlfdwtyag nvadahvlaa qklldpktrt 241 avsgetffit ndtptyfwal artvwkadgh idkhvivlkr pvaicagyls ewvskmlgke 301 pgltpfrvki vcayryhnia kakkllgytp rvgieegink tlawmdegl // LOCUS NP_011515 248 aa linear PLN 30-JUN-2025 DEFINITION protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011515 VERSION NP_011515.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181130.3 REFERENCE 1 (residues 1 to 248) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 248) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 248) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 248) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08099. On Jul 30, 2012 this sequence version replaced NP_011515.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..248 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..248 /product="protein-lysine N-methyltransferase" /calculated_mol_wt="28451" Region <20..>82 /region_name="YhjR" /note="Rubrerythrin, includes spore coat protein YhjR [Inorganic ion transport and metabolism]; COG1633" /db_xref="CDD:441240" Region 64..180 /region_name="N6-adenineMlase" /note="Probable N6-adenine methyltransferase; pfam10237" /db_xref="CDD:463014" CDS 1..248 /gene="EFM5" /locus_tag="YGR001C" /gene_synonym="AML1" /coded_by="NM_001181130.3:1..747" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016279 protein-lysine N-methyltransferase activity [PMID:26545399]" /experiment="EXISTENCE:direct assay:GO:0018023 peptidyl-lysine trimethylation [PMID:26545399]" /experiment="EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:25446118]" /experiment="EXISTENCE:mutant phenotype:GO:0018023 peptidyl-lysine trimethylation [PMID:25446118]" /note="S-adenosylmethionine-dependent lysine methyltransferase; involved in the trimethylation of eEF1A (Tef1p/Tef2p) at lysine 79; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in budding yeast; expresses a circular RNA; originally misclassified as a N-6-adenine specific DNA methyltransferase based on sequence similarity; both Efm5p and human ortholog N6AMT2 can methylate eEF1a from either species in vitro" /db_xref="GeneID:852884" /db_xref="SGD:S000003233" ORIGIN 1 msdsdsdsdy eltlsanala aleefkreeq qhqeafqkly detdedfqkk kkeegmklfk 61 edwqlsqfwy sddtaailad ailegadent viaivsapsv yaaiqkkptn eiptehiylf 121 efdkrfella grdhfffydy nkpldfsdei kgkvdrllid ppflnedcqt kssitakcll 181 apndnsktkk gvfkhrlisc tgermsevis kvysdtritt flpehsngls nefrcyanfe 241 csswkfas // LOCUS NP_011516 476 aa linear PLN 30-JUN-2025 DEFINITION Swc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011516 VERSION NP_011516.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181131.1 REFERENCE 1 (residues 1 to 476) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 476) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 476) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 476) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08100. Method: conceptual translation. FEATURES Location/Qualifiers source 1..476 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..476 /product="Swc4p" /calculated_mol_wt="55082" Region 109..213 /region_name="SANT_DAMP1_like" /note="SANT/Myb-like domain of DAMP1; pfam16282" /db_xref="CDD:465084" CDS 1..476 /gene="SWC4" /locus_tag="YGR002C" /gene_synonym="EAF2; GOD1" /coded_by="NM_001181131.1:1..1431" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14690608|PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15353583|PMID:15485911]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18439903]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15302830]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:14690608]" /note="Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex; associates with and protects nucleosome-free regions of the genome including rDNA, tDNA and telomeric loci, contributing to genome integrity" /db_xref="GeneID:852885" /db_xref="SGD:S000003234" ORIGIN 1 msssdifdvl nikqksrspt ngqvsvpsss aanrpkpqvt gmqrelfnll genqppvvik 61 sgnnfkekml stskpspwsf vefkannsvt lrhwvkgske ligdtpkesp yskfnqhlsi 121 psftkeeyea fmnenegtqk sveseknhne nftnekkdes knswsfeeie ylfnlckkyd 181 lrwflifdry synnsrtled lkekfyytcr nyfkasdpsn pllsslnfsa ekeierkkyl 241 qrllsrsaae iaeeealvve skkfemaakr tlaeresllr lldsphsdqt itqyltsqgm 301 sqlynallad ktrkrkhdln ipenpwmkqq qqfaqhrqlq qlnvkksevk enlspkktkr 361 qrqemqtalk rksesayaeq llkdfnsder kalgvithge klspgvylrs tklstfkpal 421 qnkilailqe lslpsrpvmp sfdvmerqee llkkintlid lkkhvdkyea gmsitk // LOCUS NP_011517 744 aa linear PLN 30-JUN-2025 DEFINITION cullin CUL3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011517 VERSION NP_011517.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181132.1 REFERENCE 1 (residues 1 to 744) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 744) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 744) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 744) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08101. Method: conceptual translation. FEATURES Location/Qualifiers source 1..744 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..744 /product="cullin CUL3" /calculated_mol_wt="85985" Region 1..744 /region_name="COG5647" /note="Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]" /db_xref="CDD:227934" CDS 1..744 /gene="CUL3" /locus_tag="YGR003W" /coded_by="NM_001181132.1:1..2235" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:12676951|PMID:16675952]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:16675952]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:17296727]" /experiment="EXISTENCE:mutant phenotype:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:17296727]" /note="Ubiquitin-protein ligase; forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3" /db_xref="GeneID:852886" /db_xref="SGD:S000003235" ORIGIN 1 mitnkkikis vpeklglsee sfeeswetvk yaidhiysdd madlsfeqvy ktiytivlnk 61 kgpilynrlk dyliqklall retivkdnth dyeflgtmar lwevqchcfk itgdlmmymd 121 kvyckpnrcm evydmcldlf rieilqkcss slisalisdi erirnlgsvd sehtslwkvl 181 igmmetlhdn rdsffltdfe pvlisateey ynkaidiell tpieslekir klrqfesmld 241 ssflnvdshn klktvlenvl iwgklsdiie dltheamvis ngkllqeiyd lsseekyrvt 301 viesiksyin knainipfne gnrkkgqnai twsseively rsqhsflesi dfgsvrlnnl 361 tgdvsnailg dvfsmyfske galpseylst yvdhcmkrtk ekdaeivkik qdlldstkli 421 glltekdife kiykkqlsrr llqqrslvei ekwmvqmikk vlgtfftskl eimlrdisls 481 semyqafqhs tinsieylsf apqvltrtsw pfqstnpide gislpprmsq ilagfegyys 541 lkykervlkw ahhlsvieig cqfnsgyyei sfsvyagvif llfedyeelt lgeiyelthi 601 piddvkslvm smstiprcki lkkssssgnm kfsvnyffss pnrkvkvpvi acplpsqksd 661 nlatassvdt ydneivmels aiivrimkte gklshqqlle rttkrtqsrl sltpsilkrs 721 iqlliekeyi qrnaddpsyy hyls // LOCUS NP_011518 462 aa linear PLN 30-JUN-2025 DEFINITION peroxisome biogenesis protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011518 VERSION NP_011518.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181133.1 REFERENCE 1 (residues 1 to 462) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 462) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 462) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 462) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08102. Method: conceptual translation. FEATURES Location/Qualifiers source 1..462 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..462 /product="peroxisome biogenesis protein" /calculated_mol_wt="52812" Region 51..394 /region_name="Pex24p" /note="Integral peroxisomal membrane peroxin; pfam06398" /db_xref="CDD:399414" CDS 1..462 /gene="PEX31" /locus_tag="YGR004W" /coded_by="NM_001181133.1:1..1389" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:14617799]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:1900063 regulation of peroxisome organization [PMID:27872254]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:14617799]" /note="Peroxisomal integral membrane protein; involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p; PEX31 has a paralog, PEX30, that arose from the whole genome duplication" /db_xref="GeneID:852887" /db_xref="SGD:S000003236" ORIGIN 1 mseinnenle ptsstvaest esknkhirsa lrkrrgklsa qtyeedqeai lssplltstp 61 ktvsrslvrl ypylivvdnf lsiitwsndn vsanllgifl ftvcvlyfgf itryfghlmi 121 vgiiwvylli dkhvqetmas cpslddiihv mdrvsmkssa vlspitilsa qdvrrllfti 181 aflspvyifl tvfvlspnyl mligglyvlt yhsklirrmr rylwkfrvvr llvffitgld 241 lggpdnnrrl fasvnkkirs fvwnevgnts ntkktvlfkv alfenqrrwl gigwtstmls 301 yeraswtdef lntspspevf tlpeeqsgma wewhdkdwml dltndgiiql pasaaktkvk 361 pgadegfiyy dntwnnpsat dtykkytrrr rwirtatvtt tyddeptvek atpnshalks 421 eennrvrkrk vsfstanevh iipssdsskl iqisdvsmsp sl // LOCUS NP_011519 400 aa linear PLN 30-JUN-2025 DEFINITION transcription factor IIF subunit TFG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011519 VERSION NP_011519.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181134.3 REFERENCE 1 (residues 1 to 400) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 400) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 400) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 400) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08103. On Jul 30, 2012 this sequence version replaced NP_011519.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..400 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..400 /product="transcription factor IIF subunit TFG2" /calculated_mol_wt="46474" Region 33..400 /region_name="TFG2" /note="Transcription initiation factor IIF, small subunit (RAP30) [Transcription]; COG5090" /db_xref="CDD:227421" Site order(56..57,63,65,68..75,78,81,84,91..99,103,129..139,212, 214..215,221) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:259828" CDS 1..400 /gene="TFG2" /locus_tag="YGR005C" /coded_by="NM_001181134.3:1..1203" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:14749386]" /experiment="EXISTENCE:direct assay:GO:0005674 transcription factor TFIIF complex [PMID:12242279|PMID:7995524]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:18362165|PMID:1331084]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:18362165]" /experiment="EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:15572698|PMID:20033062]" /note="TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30" /db_xref="GeneID:852888" /db_xref="SGD:S000003237" ORIGIN 1 mssgsagapa lsnnstnsva keksgnisgd eylsqeeevf dgndiennet kvyeesldld 61 lersnrqvwl vrlpmflaek wrdrnnlhgq elgkirinkd gskitlllne ndndsiphey 121 dleltkkvve neyvfteqnl kkyqqrkkel eadpekqrqa ylkkqereee lkkkqqqqkr 181 rnnrkkfnhr vmtdrdgrdr yipyvktipk ktaivgtvch ecqvmpsmnd pnyhkiveqr 241 rnivklnnke rittldetvg vtmshtgmsm rsdnsnflkv grekaksnik sirmpkkeil 301 dylfklfdey dywslkglke rtrqpeahlk ecldkvatlv kkgpyafkyt lrpeykklke 361 eerkatlgel adeqtgsagd naqgdaeadl edeiemedvv // LOCUS NP_011520 251 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein PRP18 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011520 VERSION NP_011520.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181135.1 REFERENCE 1 (residues 1 to 251) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 251) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 251) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 251) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08104. On Feb 2, 2004 this sequence version replaced NP_011520.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..251 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..251 /product="mRNA splicing protein PRP18" /calculated_mol_wt="28246" Region 116..243 /region_name="Prp18" /note="Prp18 domain; pfam02840" /db_xref="CDD:460720" CDS 1..251 /gene="PRP18" /locus_tag="YGR006W" /coded_by="NM_001181135.1:1..756" /experiment="EXISTENCE:direct assay:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:12212850]" /experiment="EXISTENCE:direct assay:GO:0000386 second spliceosomal transesterification activity [PMID:12212850]" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:8474454]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:8474454]" /experiment="EXISTENCE:direct assay:GO:0071021 U2-type post-spliceosomal complex [PMID:12212850]" /experiment="EXISTENCE:genetic interaction:GO:0000386 second spliceosomal transesterification activity [PMID:17626844]" /experiment="EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:14718167]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:12403466]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:14718167]" /note="Splicing factor and component of snRNP U5; factor involved in the positioning of the 3' splice site during the second catalytic step of splicing; interacts with Slu7p" /db_xref="GeneID:852889" /db_xref="SGD:S000003238" ORIGIN 1 mdldlasilk geiskkkkel anskgvqppc tekfqphesa nidetprqve qestdeenls 61 dnqsddirtt isklenrper iqeaiaqdkt isviidpsqi gstegkplls mkcnlyihei 121 lsrwkaslea yhpelfldtk kalfplllql rrnqlapdll islatvlyhl qqpkeinlav 181 qsymklsign vawpigvtsv giharsahsk iqggrnaani midertrlwi tsikrlitfe 241 ewytsnhdsl a // LOCUS NP_011521 323 aa linear PLN 30-JUN-2025 DEFINITION ethanolamine-phosphate cytidylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011521 VERSION NP_011521.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181136.1 REFERENCE 1 (residues 1 to 323) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 323) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 323) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 323) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08105. Method: conceptual translation. FEATURES Location/Qualifiers source 1..323 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..323 /product="ethanolamine-phosphate cytidylyltransferase" /EC_number="2.7.7.14" /calculated_mol_wt="36732" Region 6..157 /region_name="CCT" /note="CTP:phosphocholine cytidylyltransferase; cd02174" /db_xref="CDD:173925" Region 9..321 /region_name="PTZ00308" /note="ethanolamine-phosphate cytidylyltransferase; Provisional" /db_xref="CDD:140329" Site order(13..16,20,22..23,26,46,55,83..84,101..102,115, 128..130,133) /site_type="active" /db_xref="CDD:173925" Site 20..23 /site_type="other" /note="(T/H)XGH motif" /db_xref="CDD:173925" CDS 1..323 /gene="ECT1" /locus_tag="YGR007W" /gene_synonym="MUQ1" /coded_by="NM_001181136.1:1..972" /experiment="EXISTENCE:direct assay:GO:0004306 ethanolamine-phosphate cytidylyltransferase activity [PMID:8982874]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004306 ethanolamine-phosphate cytidylyltransferase activity [PMID:8982874]" /experiment="EXISTENCE:mutant phenotype:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:8982874]" /note="Ethanolamine-phosphate cytidylyltransferase; catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases; inability of the null mutant to synthesize phosphatidylethanolamine and phosphatidylcholine from ethanolamine is functionally complemented by human PCYT2" /db_xref="GeneID:852890" /db_xref="SGD:S000003239" ORIGIN 1 mtvnldpdkv widgcfdfth hghagailqa rrtvskengk lfcgvhtded iqhnkgtpvm 61 nsseryehtr snrwcsevve aapyvtdpnw mdkyqcqyvv hgdditidan gedcyklvke 121 mgrfkvvkrt ygvstteiih riltkkslpp thpdyypttq elsfysvaqd avskhcyvfq 181 rdldnvlvng gykfdaedcv yvdgdfdlfh mgdidqlrkl kmdlhpdkkl ivgittsdys 241 stimtmkerv lsvlsckyvd aviidadats msqyncekyh igtavltaag kfseyltkel 301 ivkrvesqre vyiarnqkkg msi // LOCUS NP_011522 84 aa linear PLN 30-JUN-2025 DEFINITION ATPase-stabilizing factor family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011522 VERSION NP_011522.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181137.1 REFERENCE 1 (residues 1 to 84) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 84) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 84) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 84) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08106. Method: conceptual translation. FEATURES Location/Qualifiers source 1..84 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..84 /product="ATPase-stabilizing factor family protein" /calculated_mol_wt="9483" CDS 1..84 /gene="STF2" /locus_tag="YGR008C" /coded_by="NM_001181137.1:1..255" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22442684]" /experiment="EXISTENCE:mutant phenotype:GO:0071465 cellular response to desiccation [PMID:22442684]" /note="Protein involved in resistance to desiccation stress; Stf2p exhibits antioxidant properties, and its overexpression prevents ROS accumulation and apoptosis; binds to F0 sector of mitochondrial F1F0 ATPase in vitro and may modulate the inhibitory action of Inh1p and Stf1p; protein abundance increases in response to DNA replication stress; STF2 has a paralog, TMA10, that arose from the whole genome duplication" /db_xref="GeneID:852891" /db_xref="SGD:S000003240" ORIGIN 1 mtrtnkwter egkadpkyfs htgnygespn hikkqgsgkg nwgkpgdeid dlidngeipp 61 vfkkdrrgsn lqsheqkfen vqke // LOCUS NP_011523 651 aa linear PLN 30-JUN-2025 DEFINITION Sec9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011523 VERSION NP_011523.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181138.3 REFERENCE 1 (residues 1 to 651) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 651) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 651) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 651) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08107. On Jul 30, 2012 this sequence version replaced NP_011523.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..651 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..651 /product="Sec9p" /calculated_mol_wt="73493" Region 431..500 /region_name="SNARE_SEC9N" /note="N-terminal SNARE motif of SEC9; cd15886" /db_xref="CDD:277239" Site order(433,436..441,443..448,450..451,454..455,457..462, 464..465,467..469,471..476,478..479,481..483,485..486, 488..490,492..493,495..497,499..500) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277239" Site 468 /site_type="active" /note="zero layer [active]" /db_xref="CDD:277239" Region 596..649 /region_name="SNARE_SEC9C" /note="C-terminal SNARE motif of SEC9; cd15857" /db_xref="CDD:277210" Site order(597..602,604..609,611..613,615..616,619..620, 622..623,625..627,629..630,632..633,636..637,639..644, 646..647) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277210" Site 622 /site_type="other" /note="zero layer" /db_xref="CDD:277210" CDS 1..651 /gene="SEC9" /locus_tag="YGR009C" /gene_synonym="HSS7" /coded_by="NM_001181138.3:1..1956" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:16339720]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9195974]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:12913108]" /note="t-SNARE protein required for secretory vesicle-plasma membrane fusion; similar to but not functionally redundant with Spo20p; interacts non-exocyst bound Sec6p; SNAP-25 homolog" /db_xref="GeneID:852892" /db_xref="SGD:S000003241" ORIGIN 1 mglkkffkik ppeeatpeqn kdtlmelgis vknpskkrke kfaaygkfan dkaedkvyap 61 pgyeqyarpq deledlnasp ldananeata gsnrgssgtq dlgngaesns mqdpyaiend 121 dyrydddpya rfqanksngr gsvnaapygd ygggyngtsl nsynndgpys nqntsnswvn 181 angrnslnhs nstlnvgpsr qtrqppvsts tnslsldqrs planpmqekr npyadmnsyg 241 gaydsntnrs sgtrqgsskn anpyasmand sysngnlnrs anpyssrsvr qpqsqqapmt 301 ytpsfiasde aarnsevdln eeprtgefdf eevyadksae nraaldepdl navmtnedsi 361 dlnasevdhs srqqqqqqwf mdeqqqqqqh fnatnnqygd qrgyktfeei qkeeearqqq 421 eedeavdeik qeikftkqss vastrntlkm aqdaeragmn tlgmlghqse qlnnvegnld 481 lmkvqnkvad ekvaelkkln rsilavhvsn pfnskrrrre reeqlknrki eeklmreqts 541 qqlsqstqri egamnannni sevreryqrk nvlekakryq fendeeddem eleidrnldq 601 iqqvsnrlkk malttgkeld sqqkrlnnie estddldinl hmntnrlagi r // LOCUS NP_011524 395 aa linear PLN 30-JUN-2025 DEFINITION nicotinamide-nucleotide adenylyltransferase NMA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011524 VERSION NP_011524.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181139.1 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08108. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..395 /product="nicotinamide-nucleotide adenylyltransferase NMA2" /EC_number="2.7.7.1" /EC_number="2.7.7.18" /calculated_mol_wt="44778" Region 160..380 /region_name="NMNAT_Eukarya" /note="Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic; cd09286" /db_xref="CDD:185681" Site order(164..168,172,174..175,178,279,281..282,284,347) /site_type="active" /db_xref="CDD:185681" Site 172..175 /site_type="other" /note="(T/H)XGH motif" /db_xref="CDD:185681" CDS 1..395 /gene="NMA2" /locus_tag="YGR010W" /coded_by="NM_001181139.1:1..1188" /experiment="EXISTENCE:direct assay:GO:0000309 nicotinamide-nucleotide adenylyltransferase activity [PMID:21621500]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11884393]" /experiment="EXISTENCE:direct assay:GO:0009435 NAD+ biosynthetic process [PMID:21621500]" /note="Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); homolog of human NMNAT; NMA2 has a paralog, NMA1, that arose from the whole genome duplication" /db_xref="GeneID:852893" /db_xref="SGD:S000003242" ORIGIN 1 mdptkapdfk ppqpneelqp ppdpthtipk sgpivpyvla dynssidapf nldiyktlss 61 rkknanssnr mdhiplntsd fqplsrdvss eeesegqsng idatlqdvtm tgnlgvlksq 121 iadleevpht ivrqartied yefpvhrltk klqdpeklpl iivacgsfsp itylhlrmfe 181 malddineqt rfevvggyfs pvsdnyqkrg lapayhrvrm celacertss wlmvdawesl 241 qssytrtakv ldhfnheini krggimtvdg ekmgvkimll aggdliesmg ephvwadsdl 301 hhilgnygcl ivertgsdvr sfllshdimy ehrrniliik qliyndisst kvrlfirrgm 361 svqyllpnsv iryiqeynly inqsepvkqv ldske // LOCUS NP_011526 393 aa linear PLN 30-JUN-2025 DEFINITION putative cysteine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011526 VERSION NP_011526.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181141.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08109. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..393 /product="putative cysteine synthase" /EC_number="2.5.1.47" /calculated_mol_wt="42670" Region 54..372 /region_name="CBS_like" /note="This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of...; cd01561" /db_xref="CDD:107204" Site order(58..60,73,79,81,125,128,144..145,148..149,152..153, 216..217,328..330,332..334,358,368,371) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:107204" Site order(86,118,229..234,292,338,364..365) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:107204" Site 86 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:107204" CDS 1..393 /gene="MCY1" /locus_tag="YGR012W" /gene_synonym="TCD3" /coded_by="NM_001181141.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /note="Putative cysteine synthase; localized to the mitochondrial outer membrane; interacts with TCD1 and TCD2, likely forming a complex" /db_xref="GeneID:852895" /db_xref="SGD:S000003244" ORIGIN 1 mscsqnktsv slawrecisi asvligayas ykyyklfktr diprpkegve eligntplvk 61 irsltkatgv niyaklelcn pagsakdrva lniiktaeel gelvrgepgw vfegtsgstg 121 isiavvcnal gyrahislpd dtsleklall eslgatvnkv kpasivdpnq yvnaakkacn 181 elkksgngir avfadqfene anwkvhyqtt gpeiahqtkg nidafiagcg tggtitgvak 241 flkerakipc hvvladpqgs gfynrvnygv mydyvekegt rrrhqvdtiv egiglnrith 301 nfhmgekfid esirvndnqa irmakylsvn dglfvgssta inavaaiqva ktlphgsniv 361 iiacdsgsrh lskfwkeake idhdvsleev ini // LOCUS NP_011527 620 aa linear PLN 30-JUN-2025 DEFINITION Snu71p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011527 VERSION NP_011527.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181142.1 REFERENCE 1 (residues 1 to 620) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 620) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 620) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 620) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08110. Method: conceptual translation. FEATURES Location/Qualifiers source 1..620 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..620 /product="Snu71p" /calculated_mol_wt="71252" Region 547..620 /region_name="PWI" /note="domain in splicing factors; smart00311" /db_xref="CDD:214609" CDS 1..620 /gene="SNU71" /locus_tag="YGR013W" /coded_by="NM_001181142.1:1..1863" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /note="Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart" /db_xref="GeneID:852896" /db_xref="SGD:S000003245" ORIGIN 1 mrdivfvspq lylssqegwk sdsaksgfip ilkndlqrfq dslkhivdar nslsetllns 61 nddgsihnsd qntglnkdke asiadnnsan kcatsssryq elkqflpisl dqqihtvslq 121 gvsssfsrgq ieslldhcln laltetqsns alkveawssf ssfldtqdif irfskvdede 181 afvntlnyck alfafirklh edfkielhld lntkeyvedr tgtipsvkpe kasefysvfk 241 niedqtdern skkeqlddss tqykvdtntl sdlpsdaldq lckdiiefrt kvvsiekekk 301 mkstyeesrr qrhqmqkvfd qirknhsgak gsanteeedt nmededeedd teddlalekr 361 keerdleesn rryedmlhql hsntepkiks iradimsaen yeehleknrs lylkellhla 421 ndvhydhhrs fkeqeerrde edrakngnak elapiqlsdg kaisagkaaa itlpegtvks 481 enynadknvs essehvkikf dfkkaidhsv esssedegyr eselpptkps ersaaedrlp 541 ftadelnirl tnlkesryvd elvreflgvy edelveyile nirvnqskqa llnelretfd 601 edgetiadrl wsrkefrlgt // LOCUS NP_011528 1306 aa linear PLN 30-JUN-2025 DEFINITION Msb2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011528 VERSION NP_011528.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181143.3 REFERENCE 1 (residues 1 to 1306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1306) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08111. On Jul 30, 2012 this sequence version replaced NP_011528.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1306 /product="Msb2p" /calculated_mol_wt="132984" Region 10..>215 /region_name="Chi1" /note="Chitinase [Carbohydrate transport and metabolism]; COG3469" /db_xref="CDD:442692" CDS 1..1306 /gene="MSB2" /locus_tag="YGR014W" /coded_by="NM_001181143.3:1..3921" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:18591427]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:15256499]" /experiment="EXISTENCE:genetic interaction:GO:0006972 hyperosmotic response [PMID:17627274]" /experiment="EXISTENCE:genetic interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:17627274]" /experiment="EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:2690082]" /experiment="EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:15256499|PMID:18591427]" /experiment="EXISTENCE:mutant phenotype:GO:0005034 osmosensor activity [PMID:12052881]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12052881]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:12052881]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:19439450]" /note="Mucin family member involved in various signaling pathways; functions as osmosensor in the Sho1p-mediated HOG pathway; functions in Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; processed into secreted and cell-associated forms by aspartyl protease Yps1p; potential Cdc28p substrate" /db_xref="GeneID:852897" /db_xref="SGD:S000003246" ORIGIN 1 mqfpfaclls tlvisgslar aspfdfifgn gtqqaqsqse sqgqvsftne asqdssttsl 61 vtaysqgvhs hqsativsat isslpstwyd asstsqtsvs yasqesdyav nqnswsastn 121 qlpststtsy yaptfstsad faassvnaas dvstasvpid tsansipftt tsnietttsa 181 pltsdtplis tstmsaadnv fssanpisas ltttdssesf dqtstagaip vqssadfsss 241 seilvqssad fsspsspttt dislsaaplq tsesssftta saalpvsstd vdgssaspvv 301 smsaagqias ssstdnptms etfsltstev dgsdvsstvs allsapflqt stsnsfsivs 361 psvsfvpsqs ssdvasssta nvvsssfsdi ppqtstsgsv vsvaqsasal afqsstevyg 421 asasstmssl lsttslqstt ldssslasss asssdltdyg vsstasipll saseqastss 481 sfsvvspsvs fvpsqsssdv astsapsvvs ssfsytslqa ggssmtnpss stivyssstg 541 sseesaasta satlsgssst ymagnlqsqp pstssllses qatstsavla sssvsttspy 601 ttaggastea sslisstsae tsqvsysqst talqtssfas ssttegsets sqgfstssvl 661 vqmpssisse fspsqtttqm nsassssqyt isstgilsqv sdtsvsytts sssvsqvsdt 721 pvsyttssss vsqvsdtpvs yttssssvsq vsdtpvsytt ssssvsqvsd tpvsyttsss 781 svsqvsdtsv pstssrssvs qvsdtpvpst ssrssvsqts sslqptttss qrftisthga 841 lsesssvsqq aseitssina taseyhsiqt taatqsttls ftdansssas aplevatstp 901 tpsskassll ltpstsslsq vatntnvqts lttesttvle psttnssstf slvtssdnnw 961 wiptelitqa peaastasst vggtqtmtlp haiaaatqvp epegytliti gfkkalnyef 1021 vvsepkssaq ifgylpealn tpfknvftni tvlqivplqd dslnylvsva evyfptaeie 1081 elsnlitnss safytdgmgt aksmaamvds sipltgllhd snsnsggssd gssssnsnsg 1141 ssgsgsnsns gvssssgnsy qdagtleyss ksnsnvstss kskkkiiglv igvvvggcly 1201 ilfmifafky iirrriqsqe iiknpeissi sssefggekn ynnekrmsvq esitqsmriq 1261 nwmddsyygh gltnndstpt rhntsssipk isrpiasqns lgwnev // LOCUS NP_011529 328 aa linear PLN 30-JUN-2025 DEFINITION putative hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011529 VERSION NP_011529.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181144.1 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08112. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..328 /product="putative hydrolase" /EC_number="2.3.1.268" /EC_number="3.1.2.1" /calculated_mol_wt="37806" Region 39..309 /region_name="Abhydrolase_1" /note="alpha/beta hydrolase fold; pfam00561" /db_xref="CDD:395444" CDS 1..328 /gene="EAT1" /locus_tag="YGR015C" /coded_by="NM_001181144.1:1..987" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016453 C-acetyltransferase activity [PMID:28356220]" /note="Ethanol acetyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion" /db_xref="GeneID:852898" /db_xref="SGD:S000003247" ORIGIN 1 msrlahnkal pykiivdlsf hrtrlpsdvs slikfeqrpa iinihgllgs hvmfhslnkl 61 lsrkldadif svdvrnhgis pkaipydytt ltndliyfie thiglerpiy llgfsmggki 121 allttlykni nirkcisidl ppyetpeldp milqnydlim riirrdvkil rgspswqkkv 181 lelfkslecn krkcggaval yfangflsvk snnvhqaqlh yeqqqhdpyi nysmplssmp 241 nlldevkkwp dlsnqrdffq kgtasrkvlf mkglqsnfin ndysllrynf pcadvrefnt 301 ghnlllenpe dsfkcilnff aeetldfe // LOCUS NP_011530 190 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR016W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011530 VERSION NP_011530.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181145.1 REFERENCE 1 (residues 1 to 190) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 190) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 190) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 190) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08113. Method: conceptual translation. FEATURES Location/Qualifiers source 1..190 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..190 /product="uncharacterized protein" /calculated_mol_wt="22095" CDS 1..190 /locus_tag="YGR016W" /coded_by="NM_001181145.1:1..573" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein" /db_xref="GeneID:852899" /db_xref="SGD:S000003248" ORIGIN 1 msrlrrfnrk ilslssdyth dgesdqedvs ilpldteeqe eliqkfetna hitnklyinl 61 lsilyllygg llmilvrksr gyiklallag anslicscit lrydivndyl lfkkfklrvs 121 nfsiniinii llvlmawisf nhvvedkktv lclqvpmflf wvavlvkrwa rniedeiadl 181 rclkykykna // LOCUS NP_001418068 35 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR016C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001418068 VERSION NP_001418068.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001431139.1 REFERENCE 1 (residues 1 to 35) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 35) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 35) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 35) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 35) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 35) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 35) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 35) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DBA54439. Method: conceptual translation. FEATURES Location/Qualifiers source 1..35 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..35 /product="uncharacterized protein" /calculated_mol_wt="3843" CDS 1..35 /locus_tag="YGR016C-A" /coded_by="NM_001431139.1:1..108" /note="Endoplasmic reticulum hypothetical protein; deletion confers resistance to fluconazole and to osmotic stress" /db_xref="GeneID:91000623" /db_xref="SGD:S000350096" ORIGIN 1 mavysyypid mvllahligi iyliiilgtl vmlfs // LOCUS NP_011531 297 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR017W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011531 VERSION NP_011531.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181146.1 REFERENCE 1 (residues 1 to 297) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 297) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 297) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 297) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08114. Method: conceptual translation. FEATURES Location/Qualifiers source 1..297 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..297 /product="uncharacterized protein" /calculated_mol_wt="34548" Region 5..297 /region_name="COG5135" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:444058" Region 5..115 /region_name="Pyridox_oxase_2" /note="Pyridoxamine 5'-phosphate oxidase; pfam12766" /db_xref="CDD:432768" CDS 1..297 /locus_tag="YGR017W" /coded_by="NM_001181146.1:1..894" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Pyridoxamine-phosphate oxidase-related protein (PNPO-RP); deletion causes significant increase in 4.5.6-NADH3" /db_xref="GeneID:852900" /db_xref="SGD:S000003249" ORIGIN 1 mshqmapwip mfiqscknnt epfvsfqfat vdeltnkprc rtvvfrdflf hdkrtnvltf 61 ntdmrsskit esfitpnsnn ssdskrcetp ffeacfyfpe tweqyrfsgq cftiskqfkk 121 ipaeivtkyd ifsprfsetn ddstdeeidt pinddddddk nndadnndin ednkliesie 181 ndehhededd yypqpqewea ellrqwssls rhtkslyrkp apgqkltset skqldklhrg 241 vdgakedagl enfgivclcv dsvdflnlke grggerwifq ktdgkdedlw eeqevcp // LOCUS NP_001257676 109 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR018C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257676 VERSION NP_001257676.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270747.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35110. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..109 /product="uncharacterized protein" /calculated_mol_wt="11766" CDS 1..109 /locus_tag="YGR018C" /coded_by="NM_001270747.1:1..330" /note="hypothetical protein; mRNA identified as translated by ribosome profiling data; partially overlaps the uncharacterized ORF YGR017W" /db_xref="GeneID:852901" /db_xref="SGD:S000003250" ORIGIN 1 midishghts csshrssslp svfwkihlsp plpsfkfkks testqrqtip kfsspassla 61 pstplwslss cllvsevsfw pgagflyndl vcldredhcl snsashscg // LOCUS NP_011533 471 aa linear PLN 30-JUN-2025 DEFINITION 4-aminobutyrate transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011533 VERSION NP_011533.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181148.3 REFERENCE 1 (residues 1 to 471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 471) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08115. On Jul 30, 2012 this sequence version replaced NP_011533.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..471 /product="4-aminobutyrate transaminase" /EC_number="2.6.1.19" /calculated_mol_wt="52815" Region 5..468 /region_name="GABAtrns_euk" /note="4-aminobutyrate aminotransferase, eukaryotic type; TIGR00699" /db_xref="CDD:129782" Site order(134..136,189..190,192,262,295,297..298,326) /site_type="active" /note="inhibitor-cofactor binding pocket [active]" /db_xref="CDD:99735" Site order(135..136,189..190,262,295,298,326) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99735" Site 326 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99735" CDS 1..471 /gene="UGA1" /locus_tag="YGR019W" /coded_by="NM_001181148.3:1..1416" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:23740823]" /experiment="EXISTENCE:mutant phenotype:GO:0009450 gamma-aminobutyric acid catabolic process [PMID:3888627]" /experiment="EXISTENCE:mutant phenotype:GO:0034386 4-aminobutyrate:2-oxoglutarate transaminase activity [PMID:3888627]" /note="Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852902" /db_xref="SGD:S000003251" ORIGIN 1 msiceqyype eptkptvkte sipgpesqkq lkelgevfdt rpayfladye kslgnyitdv 61 dgntyldlya qissialgyn npalikaaqs pemiralvdr palgnfpskd ldkilkqilk 121 sapkgqdhvw sglsgadane lafkaafiyy rakqrgydad fsekenlsvm dndapgaphl 181 avlsfkrafh grlfasgstt cskpihkldf pafhwphaey psyqyplden sdanrkeddh 241 claiveelik twsipvaali iepiqseggd nhaskyflqk lrditlkynv vyiidevqtg 301 vgatgklwch eyadiqppvd lvtfskkfqs agyffhdpkf ipnkpyrqfn twcgeparmi 361 iagaigqeis dkklteqcsr vgdylfkkle glqkkypenf qnlrgkgrgt fiawdlptge 421 krdlllkklk lngcnvggca vhavrlrpsl tfeekhadif iealaksvne l // LOCUS NP_011534 118 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V1 sector ATPase subunit F [Saccharomyces cerevisiae S288C]. ACCESSION NP_011534 VERSION NP_011534.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181149.1 REFERENCE 1 (residues 1 to 118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 118) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08116. Method: conceptual translation. FEATURES Location/Qualifiers source 1..118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..118 /product="H(+)-transporting V1 sector ATPase subunit F" /calculated_mol_wt="13330" Region 1..118 /region_name="V_ATP_synt_F" /note="vacuolar ATP synthase F subunit; TIGR01101" /db_xref="CDD:130171" CDS 1..118 /gene="VMA7" /locus_tag="YGR020C" /coded_by="NM_001181149.1:1..357" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /note="Subunit F of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits" /db_xref="GeneID:852903" /db_xref="SGD:S000003252" ORIGIN 1 maekrtliav iadedtttgl llagigqitp etqeknffvy qegkttkeei tdkfnhftee 61 rddiaillin qhiaenirar vdsftnafpa ileipskdhp ydpekdsvlk rvrklfge // LOCUS NP_011535 290 aa linear PLN 30-JUN-2025 DEFINITION post-initiation translation factor DPC29 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011535 VERSION NP_011535.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181150.1 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08117. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..290 /product="post-initiation translation factor DPC29" /calculated_mol_wt="31569" Region 30..287 /region_name="Transcrip_reg" /note="Transcriptional regulator; pfam01709" /db_xref="CDD:460302" CDS 1..290 /gene="DPC29" /locus_tag="YGR021W" /coded_by="NM_001181150.1:1..873" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0099617 matrix side of mitochondrial inner membrane [PMID:36620885]" /experiment="EXISTENCE:genetic interaction:GO:0032543 mitochondrial translation [PMID:36620885]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:36620885]" /note="General post-initiation mitochondrial translation factor; peripherally associated with the matrix side of the mitochondrial inner membrane; interacts with mitoribosomal proteins in actively translating cells; human ortholog TACO1 complements the yeast null mutant" /db_xref="GeneID:852904" /db_xref="SGD:S000003253" ORIGIN 1 mlvrnrylge llknsrsfsv lnssvrsghn kwstikhgka kndaernkin nkfanqiams 61 vklgngitdp smnirlatsi elanknnvsk kvienairka sgssasgkds naselcvyeg 121 mgpggvaivv ealtdnknrt iglirsafnk angsmtptlf ffdkkgyvtm vppkmldted 181 kvlesvleiq giediapvqe daedlecdte tettgqtyea vmepadtnkv aallkergfh 241 irdlgigyna kpdmevfvqg detleklqkl ttaledidev tslytnasna // LOCUS NP_011537 551 aa linear PLN 30-JUN-2025 DEFINITION Mtl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011537 VERSION NP_011537.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181152.1 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08118. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..551 /product="Mtl1p" /calculated_mol_wt="57397" Region 315..466 /region_name="Mid2" /note="Mid2 like cell wall stress sensor; pfam04478" /db_xref="CDD:398266" CDS 1..551 /gene="MTL1" /locus_tag="YGR023W" /coded_by="NM_001181152.1:1..1656" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27337501]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:20388713]" /experiment="EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:20388713]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10330137]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:20388713|PMID:15637049]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:20388713]" /note="Transmembrane sensor of the cell wall integrity pathway (CWI); involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; structurally and functionally similar to Mid2p; MTL1 has a paralog, MID2, that arose from the whole genome duplication" /db_xref="GeneID:852905" /db_xref="SGD:S000003255" ORIGIN 1 mascnptrkk ssasslsmwr tilmalttlp lsvlsqelvp ansttsstap sitslsaves 61 ftsstdatss aslstpsias vsftsfpqss slltlsstls selssssmqv sssstsssss 121 evtsssssss ispsssssti issssslptf tvastsstva sstlstsssl vistssstft 181 fssessssli sssistsvst ssvyvpssst ssppssssel tsssysssss sstlfsysss 241 fsssssssss ssssssssss ssssyftlst sssssiysss sypsfsssss snptssitst 301 sasssitpas eysnlaktit siiegqtils nyyttitysp tasassgkns hhsglskknr 361 niiigcvvgi gaplililli liymfcvqpk ktdfidsdgk ivtayrsnif tkiwyfllgk 421 kigeterfss dspigsnniq nfgdidpedi lnndnpytpk htnvegyddd ddddandenl 481 ssnfhnrgid dqysptksas ysmsnsnsqd yndadevmhd enihrvydds easidenyyt 541 kpnnglnitn y // LOCUS NP_011538 237 aa linear PLN 30-JUN-2025 DEFINITION tRNA guanylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011538 VERSION NP_011538.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181153.3 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08119. On Jul 30, 2012 this sequence version replaced NP_011538.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..237 /product="tRNA guanylyltransferase" /EC_number="2.7.7.79" /calculated_mol_wt="27626" Region 6..138 /region_name="Thg1" /note="tRNAHis guanylyltransferase; pfam04446" /db_xref="CDD:461314" Region 141..>218 /region_name="Thg1C" /note="Thg1 C terminal domain; pfam14413" /db_xref="CDD:464167" CDS 1..237 /gene="THG1" /locus_tag="YGR024C" /coded_by="NM_001181153.3:1..714" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:14633974]" /experiment="EXISTENCE:direct assay:GO:0008193 tRNA guanylyltransferase activity [PMID:14633974]" /note="tRNAHis guanylyltransferase; adds a guanosine residue to the 5' end of tRNAH is after transcription and RNase P cleavage; can also catalyze reverse (3'-5') polymerization with certain substrates in a template-dependent reaction; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes" /db_xref="GeneID:852908" /db_xref="SGD:S000003256" ORIGIN 1 manskfgyvr qfethdvilp qcyivvridg kkfhefskfy efakpndena lklmnacakn 61 lvlkykndii lafgesdeys filkssttlf nrrkdklatl fgsfftsnyv alwakffpek 121 plnikhlpyf dsrcvaypnl qtikdylswr yvdthinnly nttfwqliik cgltpqesek 181 klcgtfsnek qeilfsecgi nynnepemfk kgslvtrkge ilhinviaqi delfegy // LOCUS NP_001335780 100 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR025W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335780 VERSION NP_001335780.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348839.1 REFERENCE 1 (residues 1 to 100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 100) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80300. Method: conceptual translation. FEATURES Location/Qualifiers source 1..100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..100 /product="uncharacterized protein" /calculated_mol_wt="11579" CDS 1..100 /locus_tag="YGR025W" /coded_by="NM_001348839.1:1..303" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:852909" /db_xref="SGD:S000003257" ORIGIN 1 mtgyepfkff sirmssinsp svifktiktf npgkteeyra kkayvqdkgy lrqkrpcpfy 61 yriptctask ysigcasskk ltytrtkfkf nlvtqrensl // LOCUS NP_011540 278 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR026W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011540 VERSION NP_011540.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181155.3 REFERENCE 1 (residues 1 to 278) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 278) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 278) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 278) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08120. On Jul 30, 2012 this sequence version replaced NP_011540.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..278 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..278 /product="uncharacterized protein" /calculated_mol_wt="33124" CDS 1..278 /locus_tag="YGR026W" /coded_by="NM_001181155.3:1..837" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery" /db_xref="GeneID:852910" /db_xref="SGD:S000003258" ORIGIN 1 maktikvirk kdpkkknlsd plakqklvwk ighvltlvfg llfsityfyh vliffkyrsw 61 kwlflrvnkn ysfiqskrwy mkllswspqv myrlsligvf msesvtmqqn wvglnptwnd 121 llssenfhtl liaclwffgg gksfykilpy milsylhltk mnyelnanke ekipltpkdr 181 kmlhllayse llvilaltld tilfktgtsg fmlviyvgiy wlrlnfspya qvavlellvk 241 fekyvpkkyr dkwqviknfi ymkmkehekr teevarya // LOCUS NP_011541 108 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS25 RPS25A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011541 VERSION NP_011541.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181156.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08121. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..108 /product="40S ribosomal protein eS25 RPS25A" /calculated_mol_wt="11908" Region <25..103 /region_name="Ribosomal_S25" /note="S25 ribosomal protein; pfam03297" /db_xref="CDD:460876" CDS 1..108 /gene="RPS25A" /locus_tag="YGR027C" /gene_synonym="RPS31A" /coded_by="NM_001181156.1:1..327" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25A has a paralog, RPS25B, that arose from the whole genome duplication" /db_xref="GeneID:852911" /db_xref="SGD:S000003259" ORIGIN 1 mppkqqlska akaaaalagg kkskkkwskk smkdraqhav ildqekydri lkevptyryv 61 svsvlvdrlk iggslarial rhlekegiik piskhskqai ytratase // LOCUS NP_058159 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058159 VERSION NP_058159.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184431.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08123. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..440 /product="gag protein" /calculated_mol_wt="48925" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YGR027W-A" /coded_by="NM_001184431.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:852912" /db_xref="SGD:S000007405" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqtaqshsp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_058158 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058158 VERSION NP_058158.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184432.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08122. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198527" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YGR027W-B" /coded_by="join(NM_001184432.2:1..1305, NM_001184432.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:852913" /db_xref="SGD:S000007406" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqtaqshsp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivqy gdfywvskry llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd eyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli qqcgmeevrg wscvfknsqv ticlfvddmv lfsknlnsnk 1441 riidklkmqy dtkiinlges deeiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqq eleleeddyk mkvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsk qvldmtyeli qfiwntrdkq liwhkskpvk ptnklvvisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qeldkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_011542 362 aa linear PLN 30-JUN-2025 DEFINITION protein-degrading AAA family ATPase MSP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011542 VERSION NP_011542.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181157.3 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08124. On Jul 30, 2012 this sequence version replaced NP_011542.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..362 /product="protein-degrading AAA family ATPase MSP1" /calculated_mol_wt="40212" Region 92..255 /region_name="RecA-like_ATAD1" /note="ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; cd19520" /db_xref="CDD:410928" Site order(93..96,135..141) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:410928" Region 280..319 /region_name="AAA_lid_3" /note="AAA+ lid domain; pfam17862" /db_xref="CDD:465537" CDS 1..362 /gene="MSP1" /locus_tag="YGR028W" /gene_synonym="YTA4" /coded_by="NM_001181157.3:1..1089" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:8226973]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:24821790]" /experiment="EXISTENCE:direct assay:GO:0045047 protein targeting to ER [PMID:31445887]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:8226973]" /note="Highly-conserved N-terminally anchored AAA-ATPase; distributed in the mitochondrial outer membrane and peroxisomes; involved in mitochondrial protein sorting; ATP-driven extractase that pulls mislocalized tail-anchored proteins into the cytosol, passing them to the GET pathway for transfer to the ER membrane for degradation, ensuring fidelity of organelle-specific localization of tail-anchored proteins; contains an N-terminal transmembrane domain and C-terminal cytoplasmic ATPase domain" /db_xref="GeneID:852915" /db_xref="SGD:S000003260" ORIGIN 1 msrkfdlkti tdlsvlvgtg islyylvsrl lndvesgpls gksreskakq slqweklvkr 61 spalaevtld ayertilssi vtpdeinitf qdiggldpli sdlhesviyp lmmpevysns 121 pllqapsgvl lygppgcgkt mlakalakes ganfisirms simdkwyges nkivdamfsl 181 anklqpciif ideidsflre rsstdhevta tlkaefmtlw dgllnngrvm iigatnrind 241 iddaflrrlp krflvslpgs dqrykilsvl lkdtkldede fdlqliadnt kgfsgsdlke 301 lcreaaldaa keyikqkrql idsgtidvnd tsslkirplk tkdftkklrm datstlssqp 361 ld // LOCUS NP_011543 189 aa linear PLN 30-JUN-2025 DEFINITION flavin-linked sulfhydryl oxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011543 VERSION NP_011543.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181158.3 REFERENCE 1 (residues 1 to 189) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 189) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 189) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 189) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08125. On Jul 30, 2012 this sequence version replaced NP_011543.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..189 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..189 /product="flavin-linked sulfhydryl oxidase" /EC_number="1.8.3.2" /calculated_mol_wt="21508" Region 4..189 /region_name="ERV1" /note="Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones]; COG5054" /db_xref="CDD:227387" CDS 1..189 /gene="ERV1" /locus_tag="YGR029W" /coded_by="NM_001181158.3:1..570" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:11493598]" /experiment="EXISTENCE:direct assay:GO:0006879 intracellular iron ion homeostasis [PMID:11493598]" /experiment="EXISTENCE:direct assay:GO:0016971 flavin-dependent sulfhydryl oxidase activity [PMID:10899311]" /experiment="EXISTENCE:mutant phenotype:GO:0016972 thiol oxidase activity [PMID:15989955]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15989955]" /experiment="EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:16181637]" /experiment="EXISTENCE:mutant phenotype:GO:0160203 mitochondrial disulfide relay system [PMID:15989955]" /note="Flavin-linked sulfhydryl oxidase of the mitochondrial IMS; N-terminus is an intrinsically disordered domain that in the cytosol helps target Erv1p to mitochondria, and in the intermembrane space oxidizes Mia40p as part of a disulfide relay system that promotes intermembrane space retention of imported proteins; functional ortholog of human GFER (ALR); human GFER carrying N-terminal 21 amino acids of Erv1p functionally complements the lethality of the erv1 null mutation" /db_xref="GeneID:852916" /db_xref="SGD:S000003261" ORIGIN 1 mkaidkmtdn ppqeglsgrk iiydedgkpc rscntlldfq yvtgkisngl knlssngkla 61 gtgaltgeas elmpgsrtyr kvdppdveql grsswtllhs vaasypaqpt dqqkgemkqf 121 lnifshiypc nwcakdfeky irenapqves reelgrwmce ahnkvnkklr kpkfdcnfwe 181 krwkdgwde // LOCUS NP_011544 158 aa linear PLN 30-JUN-2025 DEFINITION ribonuclease P/MRP protein subunit POP6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011544 VERSION NP_011544.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181159.1 REFERENCE 1 (residues 1 to 158) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 158) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 158) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 158) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08126. Method: conceptual translation. FEATURES Location/Qualifiers source 1..158 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..158 /product="ribonuclease P/MRP protein subunit POP6" /EC_number="3.1.26.5" /calculated_mol_wt="18079" Region 49..118 /region_name="Alba" /note="pfam01918" /db_xref="CDD:426509" CDS 1..158 /gene="POP6" /locus_tag="YGR030C" /coded_by="NM_001181159.1:1..477" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:26135751]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0005697 telomerase holoenzyme complex [PMID:27156450]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:17881380]" /experiment="EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9620854]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]" /note="Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop7p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852918" /db_xref="SGD:S000003262" ORIGIN 1 mingvyynei srdldissst qclrflketv ipslanngnn stsiqyhgis kndnikksvn 61 kldkqinmad rslglqqvvc ifsygphiqk mlsileifkk gyiknnkkiy qwnkltsfdi 121 kregrnelqe erlkvpilvt lvsdseiidl nlhsftkq // LOCUS NP_011545 342 aa linear PLN 30-JUN-2025 DEFINITION Imo32p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011545 VERSION NP_011545.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181160.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08127. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..342 /product="Imo32p" /calculated_mol_wt="38380" Region 74..326 /region_name="PRK10673" /note="esterase" /db_xref="CDD:182637" CDS 1..342 /gene="IMO32" /locus_tag="YGR031W" /coded_by="NM_001181160.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:28465236]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:21525245|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006629 lipid metabolic process [PMID:28465236]" /experiment="EXISTENCE:mutant phenotype:GO:0004806 triacylglycerol lipase activity [PMID:28465236]" /note="Conserved mitochondrial hypothetical protein; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1" /db_xref="GeneID:852919" /db_xref="SGD:S000003263" ORIGIN 1 mmilgkagil aqygtiyvrq ntirnnlssc ifkqslcafh slakvlqqkq vpldlsydii 61 krdavktgde gkprppiiil hglfgnklnn rsigrnlnkk lgrdvylldl rnhgssphss 121 vhnyevmsed vkhfitkhel ntnggpiiig hsmggkvamm lvlknpqlcs mlvcienapv 181 slrpnaefve yikalmeivn dkgktirtlk qadehlaeri ggnelvrrfl ltalkkvkmd 241 nsssvssytf eeriplatlk daivkgeiaa wpldparerw trpalfirat qshyvvdeyl 301 piigaffprf etrdidaghw vnaekpgeca esivdfverh ed // LOCUS NP_001027023 163 aa linear PLN 30-JUN-2025 DEFINITION Nag1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001027023 VERSION NP_001027023.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184658.1 REFERENCE 1 (residues 1 to 163) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 163) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 163) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 163) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08128. Method: conceptual translation. FEATURES Location/Qualifiers source 1..163 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..163 /product="Nag1p" /calculated_mol_wt="17405" CDS 1..163 /gene="NAG1" /locus_tag="YGR031C-A" /coded_by="NM_001184658.1:1..492" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18310357]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0042546 cell wall biogenesis [PMID:18310357]" /note="Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32" /db_xref="GeneID:8656591" /db_xref="SGD:S000028636" ORIGIN 1 mnsagrvhrs ragsrghaai spltmasfsv argirssnvy ddtddelsil tffsavrrnr 61 ltsslppils arcssacfsv rivlplslti sisalmystn salgrkltga fsiqtnieqs 121 cgffrtsima tlppiecpii igpplvfnsc fvikcftssd mts // LOCUS NP_011546 1895 aa linear PLN 30-JUN-2025 DEFINITION 1,3-beta-glucan synthase GSC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011546 VERSION NP_011546.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181161.3 REFERENCE 1 (residues 1 to 1895) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1895) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1895) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1895) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1895) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1895) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1895) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1895) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08129. On Jul 30, 2012 this sequence version replaced NP_011546.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1895 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1895 /product="1,3-beta-glucan synthase GSC2" /EC_number="2.4.1.34" /calculated_mol_wt="216860" Region 1..>162 /region_name="PilY1" /note="Type IV pilus assembly protein, tip-associated adhesin PilY1 [Cell motility, Extracellular structures]; COG3419" /db_xref="CDD:442645" Region 319..428 /region_name="FKS1_dom1" /note="1,3-beta-glucan synthase subunit FKS1, domain-1; pfam14288" /db_xref="CDD:464126" Region 827..1650 /region_name="Glucan_synthase" /note="1,3-beta-glucan synthase component; pfam02364" /db_xref="CDD:426739" CDS 1..1895 /gene="GSC2" /locus_tag="YGR032W" /gene_synonym="FKS2" /coded_by="NM_001181161.3:1..5688" /experiment="EXISTENCE:direct assay:GO:0000148 1,3-beta-D-glucan synthase complex [PMID:7983071]" /experiment="EXISTENCE:direct assay:GO:0003843 1,3-beta-D-glucan synthase activity [PMID:7649185|PMID:7565718]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:15755916]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006075 (1->3)-beta-D-glucan biosynthetic process [PMID:7565718]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:16116083]" /experiment="EXISTENCE:mutant phenotype:GO:0006075 (1->3)-beta-D-glucan biosynthetic process [PMID:7565718]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:16116083]" /note="Catalytic subunit of 1,3-beta-glucan synthase; involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; GSC2 has a paralog, FKS1, that arose from the whole genome duplication" /db_xref="GeneID:852920" /db_xref="SGD:S000003264" ORIGIN 1 msyndpnlng qyysngdgtg dgnyptyqvt qdqsaydeyg qpiytqnqld dgyydpneqy 61 vdgtqfpqgq dpsqdqgpyn ndasyynqpp nmmnpssqdg enfsdfssyg ppsgtypndq 121 ytpsqmsypd qdgssgastp ygngvvngng qyydpnaiem alpndpypaw tadpqsplpi 181 eqiedifidl tnkfgfqrds mrnmfdhfmt lldsrssrms peqallslha dyiggdtany 241 kkwyfaaqld mddeigfrnm klgklsrkar kakkknkkam qeaspedtee tlnqiegdns 301 leaadfrwks kmnqlspfem vrqialfllc wgeanqvrft peclcfiykc asdyldsaqc 361 qqrpdplpeg dflnrvitpl yrfirsqvye ivdgryvkse kdhnkvigyd dvnqlfwype 421 giakivmedg trlidlpaee rylklgeipw ddvffktyke trswlhlvtn fnriwimhis 481 vywmycayna ptfythnyqq lvdnqplaay kwataalggt vasliqvaat lcewsfvprk 541 wagaqhlsrr fwflcvimgi nlgpvifvfa ydkdtvysta ahvvgavmff vavatlvffs 601 vmplgglfts ymkkstrsyv asqtftasfa plhgldrwms ylvwvtvfaa kyaesyffli 661 lslrdpiril sttsmrctge ywwgnkickv qpkivlglmi atdfilffld tylwyivvnt 721 vfsvgksfyl gisiltpwrn iftrlpkriy skilattdme ikykpkvlis qiwnaiiism 781 yrehllaidh vqkllyhqvp seiegkrtlr aptffvsqdd nnfeteffpr dseaerrisf 841 faqslstpip eplpvdnmpt ftvltphyae rillslreii reddqfsrvt lleylkqlhp 901 vewdcfvkdt kilaeetaay ennedepeke dalksqiddl pfycigfksa apeytlrtri 961 waslrsqtly rtisgfmnys raikllyrve npeivqmfgg nadglerele kmarrkfkfl 1021 vsmqrlakfk phelenaefl lraypdlqia yldeepplne geepriysal idghceilen 1081 grrrpkfrvq lsgnpilgdg ksdnqnhali fyrgeyiqli danqdnylee clkirsvlae 1141 feelgieqih pytpglkyed qstnhpvaiv gareyifsen sgvlgdvaag keqtfgtlfa 1201 rtlaqiggkl hyghpdfina tfmttrggvs kaqkglhlne diyagmnavl rggrikhcey 1261 yqcgkgrdlg fgtilnfttk igagmgeqml sreyyylgtq lpidrfltfy yahpgfhlnn 1321 lfiqlslqmf mltlvnlhal ahesilcvyd rdkpitdvly pigcynfhpa idwvrrytls 1381 ifivfwiafv pivvqelier glwkatqrff rhilslspmf evfagqiyss allsdiavgg 1441 aryistgrgf atsripfsil ysrfagsaiy mgsrsmlmll fgtvahwqap llwfwaslsa 1501 lifapfifnp hqfawedffl dyrdyirwls rgnnkyhrns wigyvrmsrs rvtgfkrklv 1561 gdeseksagd asrahrtnli maeiipcaiy aagcfiaftf inaqtgvktt dedrvnstlr 1621 iiictlapiv idigvlffcm glsccsgpll gmcckktgsv magiahgiav vvhivffivm 1681 wvlegfsfvr mligvvtciq cqrlifhcmt vllltrefkn dhantafwtg kwystglgym 1741 awtqptrelt akvielsefa adfvlghvil ifqlpvicip kidkfhsiml fwlkpsrqir 1801 ppiyslkqar lrkrmvrryc slyflvliif agcivgpava sahvpkdlgs gltgtfhnlv 1861 qprnvsnndt gsqmstyksh yythtpslkt wstik // LOCUS NP_011547 239 aa linear PLN 30-JUN-2025 DEFINITION Tim21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011547 VERSION NP_011547.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181162.3 REFERENCE 1 (residues 1 to 239) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 239) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 239) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 239) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08130. On Jul 30, 2012 this sequence version replaced NP_011547.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..239 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..239 /product="Tim21p" /calculated_mol_wt="27074" Region 67..219 /region_name="TIM21" /note="pfam08294" /db_xref="CDD:311963" CDS 1..239 /gene="TIM21" /locus_tag="YGR033C" /coded_by="NM_001181162.3:1..720" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:15878866|PMID:15797382]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:15797382]" /note="Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity" /db_xref="GeneID:852921" /db_xref="SGD:S000003265" ORIGIN 1 mssslprsll rlghrkplfp ryntfvnssv ithtsllrtr lysngtgats gkkddktrnk 61 pkplwpqvks astftfsgil vigavgisai viylilself spsgdtqlfn ravsmveknk 121 dirsllqcdd gitgkerlka ygelitndkw trnrpivstk kldkegrthh ymrfhveskk 181 kialvhleak eskqnyqpdf inmyvdvpge kryylikpkl hpvsnskgfl girwgprkd // LOCUS NP_011548 127 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL24 RPL26B [Saccharomyces cerevisiae S288C]. ACCESSION NP_011548 VERSION NP_011548.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181163.1 REFERENCE 1 (residues 1 to 127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 127) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08131. On Oct 10, 2006 this sequence version replaced NP_011548.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..127 /product="60S ribosomal protein uL24 RPL26B" /calculated_mol_wt="14104" Region 9..122 /region_name="Ribosomal_L26" /note="Ribosomal proteins L26 eukaryotic, L24P archaeal; pfam16906" /db_xref="CDD:465307" CDS 1..127 /gene="RPL26B" /locus_tag="YGR034W" /coded_by="NM_001181163.1:1..384" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication" /db_xref="GeneID:852922" /db_xref="SGD:S000003266" ORIGIN 1 makqsldvss drrkarkayf tapsserrvl lsaplskelr aqygikalpi rrddevlvvr 61 gskkgqegki ssvyrlkfav qvdkvtkekv ngasvpinlh psklvitklh ldkdrkaliq 121 rkggkle // LOCUS NP_011549 116 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR035C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011549 VERSION NP_011549.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181164.1 REFERENCE 1 (residues 1 to 116) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 116) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 116) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 116) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08132. Method: conceptual translation. FEATURES Location/Qualifiers source 1..116 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..116 /product="uncharacterized protein" /calculated_mol_wt="12776" CDS 1..116 /locus_tag="YGR035C" /coded_by="NM_001181164.1:1..351" /note="hypothetical protein, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YGR035C has a paralog, YLR346C, that arose from the whole genome duplication" /db_xref="GeneID:852923" /db_xref="SGD:S000003267" ORIGIN 1 mlltpakttr tedsanstdd sskssnsfmr aivsslmvkp itsltntvtc rqsshhnssp 61 skitrydlik aaaendlkrs ksqgreksrr nsnrrnneei fvantaseiq rtkssi // LOCUS NP_878077 73 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR035W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878077 VERSION NP_878077.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184648.1 REFERENCE 1 (residues 1 to 73) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 73) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 73) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 73) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08133. Method: conceptual translation. FEATURES Location/Qualifiers source 1..73 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..73 /product="uncharacterized protein" /calculated_mol_wt="8231" CDS 1..73 /locus_tag="YGR035W-A" /coded_by="NM_001184648.1:1..222" /note="hypothetical protein" /db_xref="GeneID:1466457" /db_xref="SGD:S000028827" ORIGIN 1 mllylyilyi alktvshlff cnpcfrnlsv gdmlnprlsl sfftnhllcp eapliirgkg 61 sysavgnffs rkk // LOCUS NP_011550 239 aa linear PLN 30-JUN-2025 DEFINITION dolichyldiphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011550 VERSION NP_011550.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181165.3 REFERENCE 1 (residues 1 to 239) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 239) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 239) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 239) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08134. On Jul 30, 2012 this sequence version replaced NP_011550.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..239 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..239 /product="dolichyldiphosphatase" /EC_number="3.6.1.43" /calculated_mol_wt="27518" Region 17..179 /region_name="PAP2_dolichyldiphosphatase" /note="PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is...; cd03382" /db_xref="CDD:239477" Site order(78,85,106..108,153,159,163) /site_type="active" /db_xref="CDD:239477" CDS 1..239 /gene="CAX4" /locus_tag="YGR036C" /gene_synonym="CWH8" /coded_by="NM_001181165.3:1..720" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11504728]" /experiment="EXISTENCE:direct assay:GO:0047874 dolichyldiphosphatase activity [PMID:11504728]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:10024662]" /experiment="EXISTENCE:mutant phenotype:GO:0008610 lipid biosynthetic process [PMID:11504728]" /note="Dolichyl pyrophosphate (Dol-P-P) phosphatase; cleaves the anhydride linkage in Dol-P-P; involved in synthesis of Dol-P-P-linked oligosaccharide intermediate required for protein N-glycosylation; has a luminally oriented active site in the ER; mutation affects vesicular transport, membrane and cell wall biogenesis and lipid homeostasis" /db_xref="GeneID:852924" /db_xref="SGD:S000003268" ORIGIN 1 mnstaaainp npnvipfddt yilydshdfl sflsayfslm pilvlafyls wfiitrelea 61 civafgqlmn eifnnvikni ikqprpvsfg asfqndtirs gygmpsahsq fmgfcftyns 121 lkiytswknl nflekcifsg alallsfcvc fsrvylhyhn ldqvivgfsv galtgslyff 181 ivgiirelgl inwflklriv rlfymtdsyn lapltlkeny eaywkrinqr sfndkskrd // LOCUS NP_011551 87 aa linear PLN 30-JUN-2025 DEFINITION long-chain fatty acid transporter ACB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011551 VERSION NP_011551.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181166.3 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08135. On Jul 30, 2012 this sequence version replaced NP_011551.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..87 /product="long-chain fatty acid transporter ACB1" /calculated_mol_wt="9930" Region 2..86 /region_name="ACBP" /note="Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; cd00435" /db_xref="CDD:238248" Site order(10,13..14,16,19..20,22,25..26,28..29,32..33,50..51, 54..55,74) /site_type="other" /note="acyl-CoA binding pocket [chemical binding]" /db_xref="CDD:238248" Site order(14,29,32..33,55,74) /site_type="other" /note="CoA binding site [chemical binding]" /db_xref="CDD:238248" CDS 1..87 /gene="ACB1" /locus_tag="YGR037C" /coded_by="NM_001181166.3:1..264" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:20156967]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005576 extracellular region [PMID:20156967]" /experiment="EXISTENCE:mutant phenotype:GO:0036042 long-chain fatty acyl-CoA binding [PMID:11294913]" /experiment="EXISTENCE:mutant phenotype:GO:0042761 very long-chain fatty acid biosynthetic process [PMID:11294913]" /note="Acyl-CoA-binding protein; transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852925" /db_xref="SGD:S000003269" ORIGIN 1 mvsqlfeeka kavnelptkp stdellelya lykqatvgdn dkekpgifnm kdrykweawe 61 nlkgksqeda ekeyialvdq liakyss // LOCUS NP_011552 222 aa linear PLN 30-JUN-2025 DEFINITION sphingolipid homeostasis protein ORM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011552 VERSION NP_011552.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181167.1 REFERENCE 1 (residues 1 to 222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 222) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08136. Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..222 /product="sphingolipid homeostasis protein ORM1" /calculated_mol_wt="25114" Region 42..222 /region_name="COG5081" /note="Predicted membrane protein [Function unknown]" /db_xref="CDD:227413" CDS 1..222 /gene="ORM1" /locus_tag="YGR038W" /coded_by="NM_001181167.1:1..669" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:20182505|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0017059 serine palmitoyltransferase complex [PMID:20182505]" /experiment="EXISTENCE:genetic interaction:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:20182505]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:12093374]" /experiment="EXISTENCE:mutant phenotype:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:20182505]" /experiment="EXISTENCE:physical interaction:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:20182505]" /note="Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; ORM1 has a paralog, ORM2, that arose from the whole genome duplication" /db_xref="GeneID:852926" /db_xref="SGD:S000003270" ORIGIN 1 mteldyqgta eaastsysrn qtdlkpfpsa gsasssiktt epvkdhrrrr sssiishvep 61 etfedendqq llpnmnatwv dqrgawiihv viiillklfy nlfpgvttew swtltnmtyv 121 igsyvmfhli kgtpfdfngg aydnltmweq iddetlytps rkflisvpia lflvsthyah 181 ydlklfswnc flttfgavvp klpvthrlri sipgitgraq is // LOCUS NP_058160 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058160 VERSION NP_058160.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184434.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08137. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198391" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YGR038C-B" /coded_by="join(NM_001184434.2:1..1305, NM_001184434.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:852928" /db_xref="SGD:S000007408" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npginvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp nsapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmntwdtd kyydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniflln gkviggkstk asltctstte aeihavseai pllnnlshlv qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_058161 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058161 VERSION NP_058161.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184433.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08138. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..440 /product="gag protein" /calculated_mol_wt="48903" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YGR038C-A" /coded_by="NM_001184433.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:852929" /db_xref="SGD:S000007407" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_001335781 103 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR039W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335781 VERSION NP_001335781.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348840.1 REFERENCE 1 (residues 1 to 103) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 103) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 103) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 103) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80301. Method: conceptual translation. FEATURES Location/Qualifiers source 1..103 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..103 /product="uncharacterized protein" /calculated_mol_wt="12193" CDS 1..103 /locus_tag="YGR039W" /coded_by="NM_001348840.1:1..312" /note="hypothetical protein; conserved among S. cerevisiae strains; YGR039W is not an essential gene" /db_xref="GeneID:852930" /db_xref="SGD:S000003271" ORIGIN 1 mlfftglvil syllggkkdw llimyeasdy leflnrlssm lfkfelfehl sstflifshs 61 kravklleiy rsrhisiynv fllrhpkyfq svdialyltr sqt // LOCUS NP_011554 368 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated serine/threonine-protein kinase KSS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011554 VERSION NP_011554.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181169.3 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08139. On Jul 30, 2012 this sequence version replaced NP_011554.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..368 /product="mitogen-activated serine/threonine-protein kinase KSS1" /EC_number="2.7.11.24" /calculated_mol_wt="42561" Region 7..365 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(19..22,25,27,40,42,73,94..97,143,147..148,150, 160..161) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..368 /gene="KSS1" /locus_tag="YGR040W" /coded_by="NM_001181169.3:1..1107" /experiment="EXISTENCE:direct assay:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:8668180|PMID:8918885]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004707 MAP kinase activity [PMID:8668180|PMID:8918885]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18417610|PMID:7579701]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:27400980]" /experiment="EXISTENCE:genetic interaction:GO:0010973 positive regulation of division septum assembly [PMID:27400980]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:11583629]" /experiment="EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:9393860]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:8001818]" /note="Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in some S288C-related strains and functional in W303a strains" /db_xref="GeneID:852931" /db_xref="SGD:S000003272" ORIGIN 1 martitfdip sqyklvdlig egaygtvcsa ihkpsgikva ikkiqpfskk lfvtrtirei 61 kllryfhehe niisildkvr pvsidklnav ylveelmetd lqkvinnqns gfstlsddhv 121 qyftyqilra lksihsaqvi hrdikpsnll lnsncdlkvc dfglarclas ssdsretlvg 181 fmteyvatrw yrapeimltf qeyttamdiw scgcilaemv sgkplfpgrd yhhqlwlile 241 vlgtpsfedf nqikskrake yianlpmrpp lpwetvwskt dlnpdmidll dkmlqfnpdk 301 risaaealrh pylamyhdps depeypplnl ddefwkldnk imrpeeeeev piemlkdmly 361 delmktme // LOCUS NP_011555 547 aa linear PLN 30-JUN-2025 DEFINITION Bud9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011555 VERSION NP_011555.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181170.3 REFERENCE 1 (residues 1 to 547) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 547) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 547) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 547) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08140. On Jul 30, 2012 this sequence version replaced NP_011555.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..547 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..547 /product="Bud9p" /calculated_mol_wt="60620" CDS 1..547 /gene="BUD9" /locus_tag="YGR041W" /coded_by="NM_001181170.3:1..1644" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:11514631]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:8657162]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:17581861]" /note="Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole; BUD9 has a paralog, BUD8, that arose from the whole genome duplication" /db_xref="GeneID:852932" /db_xref="SGD:S000003273" ORIGIN 1 mtkitrdvsi ttenskstsg satassaslp endhpifhqp rarirsgslf iegsdsfpss 61 evksynvyid dskyseilkg dtnssstdgk qvfedarddn fhqeshrdle dsildlvrrd 121 pevaafplpp pnsnernrns sngssaetnl nghsssgtis tsvllnmgsa ekhagttrgd 181 hmesssmksf eklgtrpssl fypppegtap yqgpratvsg nkstrqtqgt ysfpsmrygv 241 dlvspvegav dvaksrvpns tlngtfpdka fiphefqipk kawnripank stslktprnh 301 sllidilkpf eaadlandqr sssavlkntv hsngqynptn etsgtrmqdq rqkntneidl 361 ekipnpqvpl giamdtmrsp nqlhekeyes nieaglasgv gkgdnsikqh qykkipqeid 421 rdqqlsfqme tmpiqridss sirsfdsriy gfseiysipr vittlciclf vpplffffsi 481 ngnngvsnyr lmrmimnyeh rigllkgfew didvqwfrtl cfvlgcieml aifasigigf 541 gvgiire // LOCUS NP_011556 271 aa linear PLN 30-JUN-2025 DEFINITION Mte1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011556 VERSION NP_011556.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181171.1 REFERENCE 1 (residues 1 to 271) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 271) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 271) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 271) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08141. Method: conceptual translation. FEATURES Location/Qualifiers source 1..271 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..271 /product="Mte1p" /calculated_mol_wt="30894" Region 5..88 /region_name="DUF2439" /note="Protein of unknown function (DUF2439); pfam10382" /db_xref="CDD:463065" CDS 1..271 /gene="MTE1" /locus_tag="YGR042W" /coded_by="NM_001181171.1:1..816" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:26966248]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:26966248]" /experiment="EXISTENCE:direct assay:GO:0035861 site of double-strand break [PMID:26966248]" /experiment="EXISTENCE:mutant phenotype:GO:0032205 negative regulation of telomere maintenance [PMID:26966248]" /note="hypothetical protein; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:852933" /db_xref="SGD:S000003274" ORIGIN 1 mlshiveyec qytdqlykkr kiwhdgrlky fqlnnrfmly tekdnvllas efkinskelk 61 ailnpegfdi eehrifsqfl viisniieey drdiqvaath vraypsnlsv qkqrplisdn 121 apslnhista revhsnikvt tpnrkqtedn atkggfnisk ltlkvnkpfk kpkrilstnv 181 vnesnrpsir sqkiqevtpq lhetntstkv qtagkvalnn dniaqgnyat iteeakvrdg 241 sdrkkdmanl sksgkrrvgg irrivheplg i // LOCUS NP_011557 333 aa linear PLN 30-JUN-2025 DEFINITION sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011557 VERSION NP_011557.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181172.1 REFERENCE 1 (residues 1 to 333) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 333) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 333) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 333) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08142. Method: conceptual translation. FEATURES Location/Qualifiers source 1..333 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..333 /product="sedoheptulose-7-phosphate:D-glyceraldehyde-3- phosphate transaldolase NQM1" /EC_number="2.2.1.2" /calculated_mol_wt="37123" Region 14..333 /region_name="talAB" /note="transaldolase; TIGR00874" /db_xref="CDD:162081" Site order(29,45,47..48,106,108,144,167,169,189,194) /site_type="active" /db_xref="CDD:188644" Site order(116,295,298,302..303,309,312,316) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:188644" Site 144 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:188644" CDS 1..333 /gene="NQM1" /locus_tag="YGR043C" /coded_by="NM_001181172.1:1..1002" /experiment="EXISTENCE:direct assay:GO:0004801 transaldolase activity [PMID:18831051]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:25887987]" /note="Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift; NQM1 has a paralog, TAL1, that arose from the whole genome duplication" /db_xref="GeneID:852934" /db_xref="SGD:S000003275" ORIGIN 1 msepsekkqk vatssleqlk kagthvvads gdfeaiskye pqdsttnpsl ilaaskleky 61 arfidaavey grkhgktdhe kienamdkil vefgtqilkv vpgrvstevd arlsfdkkat 121 vkkalhiikl ykdagvpker vlikiastwe giqaarelev khgihcnmtl lfsftqavac 181 aeanvtlisp fvgrimdfyk alsgkdytae tdpgvlsvkk iysyykrhgy atevmaasfr 241 nldelkalag idnmtlplnl leqlyestdp ienklnsesa keegvekvsf indephfryv 301 lnedqmatek lsdgirkfsa diealyklve ekm // LOCUS NP_011558 300 aa linear PLN 30-JUN-2025 DEFINITION Rme1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011558 VERSION NP_011558.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181173.1 REFERENCE 1 (residues 1 to 300) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 300) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 300) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 300) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08143. Method: conceptual translation. FEATURES Location/Qualifiers source 1..300 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..300 /product="Rme1p" /calculated_mol_wt="33773" CDS 1..300 /gene="RME1" /locus_tag="YGR044C" /gene_synonym="CSP1" /coded_by="NM_001181173.1:1..903" /experiment="EXISTENCE:direct assay:GO:0000082 G1/S transition of mitotic cell cycle [PMID:11713667]" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9580682]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9580682]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9580682|PMID:11713667|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14668363|PMID:12006664|PMID:11713667]" /experiment="EXISTENCE:direct assay:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:14668363]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8339935]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8339935]" /experiment="EXISTENCE:mutant phenotype:GO:0045835 negative regulation of meiotic nuclear division [PMID:3513021]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12006664]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:8339935]" /note="Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation; relocalizes from nucleus to cytoplasm upon DNA replication stress" /db_xref="GeneID:852935" /db_xref="SGD:S000003276" ORIGIN 1 mspcygqnsa iakgswnrev lqevqpiyhw hdfgqnmkey sasplegdss lpsslpsste 61 dclllslent itviagnqrq aydstsstee gtapqlrpde iadsthcits lvdpefrdli 121 nygrqkganp vfiesntteq shsqcilgyp qkshvaqlyh dpkvlstise gqtkrgsyhc 181 shcsekfatl vefaahldef nlerpckcpi eqcpwkilgf qqatglrrhc asqhigeldi 241 emekslnlkv ekypglncpf picqktfrrk daykrhvamv hnnadsrfnk rlkkilnntk // LOCUS NP_001335782 120 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR045C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335782 VERSION NP_001335782.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348841.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80302. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..120 /product="uncharacterized protein" /calculated_mol_wt="13514" CDS 1..120 /locus_tag="YGR045C" /coded_by="NM_001348841.1:1..363" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:852936" /db_xref="SGD:S000003277" ORIGIN 1 msqitskgrr ildkkirtfp vgftsrkvag hvlnispyfl lafsyaenkg qsafeeikgs 61 nvidmscvic fnfschlfvv ifisrsteti pttklllsky ifycvnalel tlflsyksys // LOCUS NP_011560 385 aa linear PLN 30-JUN-2025 DEFINITION putative phosphatidate cytidylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011560 VERSION NP_011560.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181175.3 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08144. On Jul 30, 2012 this sequence version replaced NP_011560.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..385 /product="putative phosphatidate cytidylyltransferase" /EC_number="2.7.7.41" /calculated_mol_wt="44069" Region 113..380 /region_name="Tam41_Mmp37" /note="Phosphatidate cytidylyltransferase, mitochondrial; pfam09139" /db_xref="CDD:462690" CDS 1..385 /gene="TAM41" /locus_tag="YGR046W" /gene_synonym="MMP37" /coded_by="NM_001181175.3:1..1158" /experiment="EXISTENCE:direct assay:GO:0004605 phosphatidate cytidylyltransferase activity [PMID:23623749]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:16943180|PMID:16790493]" /experiment="EXISTENCE:genetic interaction:GO:0032049 cardiolipin biosynthetic process [PMID:20485265]" /experiment="EXISTENCE:mutant phenotype:GO:0004605 phosphatidate cytidylyltransferase activity [PMID:23623749]" /experiment="EXISTENCE:mutant phenotype:GO:0032049 cardiolipin biosynthetic process [PMID:19114592]" /note="Mitochondrial phosphatidate cytidylyltransferase (CDP-DAG synthase); required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition" /db_xref="GeneID:852937" /db_xref="SGD:S000003278" ORIGIN 1 mlrvsenglr fllkchstnv smfnrllstq ikegrssidd agiipdgtin erpnhyiegi 61 tkgsdldlle kgirktdemt snftnymykf hrlppnygsn qlitidkelq keldgvmssf 121 kapcrfvfgy gsgvfeqagy skshskpqid iilgvtypsh fhsinmrqnp qhysslkyfg 181 sefvskfqqi gagvyfnpfa ninghdvkyg vvsmetllkd iatwntfyla grlqkpvkil 241 kndlrvqywn qlnlkaaatl akhytleknn nkfdefqfyk eitalsyagd iryklggenp 301 dkvnnivtkn ferfqeyykp iykevvlnds fylpkgftlk ntqrlllsri skssalqtik 361 gvftagitks ikyawakklk smrrs // LOCUS NP_011561 1025 aa linear PLN 30-JUN-2025 DEFINITION transcription factor TFIIIC subunit TFC4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011561 VERSION NP_011561.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181176.3 REFERENCE 1 (residues 1 to 1025) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1025) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1025) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1025) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1025) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08145. On Jul 30, 2012 this sequence version replaced NP_011561.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1025 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1025 /product="transcription factor TFIIIC subunit TFC4" /calculated_mol_wt="120098" Region 124..336 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" Region 164..190 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(197,200..201,204..205,207,231,234..235,238..239, 241..242,265,268..269,272..273,276) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 197..224 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 229..259 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 264..290 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 433..>553 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" Region 467..495 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(468,471..472,475..476,478,503,506..507,510..511, 513..514,537,540..541,544..545,548) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 501..531 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..1025 /gene="TFC4" /locus_tag="YGR047C" /gene_synonym="PCF1" /coded_by="NM_001181176.3:1..3078" /experiment="EXISTENCE:direct assay:GO:0000127 transcription factor TFIIIC complex [PMID:2180956|PMID:8387209|PMID:2002052|PMID:1474578]" /experiment="EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2404611|PMID:2649882]" /experiment="EXISTENCE:direct assay:GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding [PMID:2404611]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:3633923|PMID:2183033|PMID:8464480]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2002052]" /experiment="EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2183033]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:8264649]" /note="Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102" /db_xref="GeneID:852938" /db_xref="SGD:S000003279" ORIGIN 1 maagklkkeq qnqsaeresa dtgkvndede ehlygniddy khliqdeeyd dedvphdlql 61 sedeynserd ssllaefsdy geiseddeed fmnaireasn fkvkkkkknd kgksygrqrk 121 ervldpevaq llsqaneafv rndlqvaerl fnevikkdar nfaayetlgd iyqlqgrlnd 181 ccnswflaah lnasdwefwk ivailsadld hvrqaiycfs rvislnpmew esiyrrsmly 241 kktgqlaral dgfqrlymyn pydanilrel ailyvdydri edsielymkv fnanverrea 301 ilaalenald ssdeesaaeg edadekeple qdedrqmfpd inwkkidaky kcipfdwssl 361 nilaelflkl avsevdgikt ikkcarwiqr resqtfwdhv pddsefdnrr fknstfdsll 421 aaekeksyni pidirvrlgl lrlntdnlve alnhfqclyd etfsdvadly feaataltra 481 ekykeaidff tpllsleewr ttdvfkplar cykeiesyet akefyelaik sepddldirv 541 slaevyyrln dpetfkhmlv dvvemrkhqv detlhrisne kssndtsdis skplledskf 601 rtfrkkkrtp ydaererier erritakvvd kyekmkkfel nsglneakqa siwintvsel 661 vdifssvknf fmksrsrkfv gilrrtkkfn teldfqierl sklaegdsvf egplmeervt 721 ltsatelrgl syeqwfelfm elslviakyq svedglsvve taqevnvffq dpervkmmkf 781 vklaivlqmd deeelaenlr gllnqfqfnr kvlqvfmysl crgpsslnil sstiqqkffl 841 rqlkafdscr yntevngqas itnkevynpn kksspylyyi yavllyssrg flsalqyltr 901 leedipddpm vnllmglshi hramqrltaq rhfqifhglr ylyryhkirk slytdlekqe 961 adynlgrafh liglvsiaie yynrvlenyd dgklkkhaay nsiiiyqqsg nveladhlme 1021 kylsi // LOCUS NP_011562 361 aa linear PLN 30-JUN-2025 DEFINITION polyubiquitin-binding protein UFD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011562 VERSION NP_011562.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181177.1 REFERENCE 1 (residues 1 to 361) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 361) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 361) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 361) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08146. Method: conceptual translation. FEATURES Location/Qualifiers source 1..361 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..361 /product="polyubiquitin-binding protein UFD1" /calculated_mol_wt="39679" Region 16..361 /region_name="UFD1" /note="Ubiquitin fusion-degradation protein [Posttranslational modification, protein turnover, chaperones]; COG5140" /db_xref="CDD:227469" CDS 1..361 /gene="UFD1" /locus_tag="YGR048W" /coded_by="NM_001181177.1:1..1086" /experiment="EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873065|PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873065|PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:11733065]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006274 DNA replication termination [PMID:31509741]" /experiment="EXISTENCE:direct assay:GO:0030894 replisome [PMID:31509741]" /experiment="EXISTENCE:direct assay:GO:0031593 polyubiquitin modification-dependent protein binding [PMID:16004872]" /experiment="EXISTENCE:direct assay:GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex [PMID:11598205|PMID:11733065]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:16004872]" /experiment="EXISTENCE:direct assay:GO:1990112 RQC complex [PMID:23178123]" /experiment="EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:11813000|PMID:11740563]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11813000|PMID:11739805|PMID:11740563]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:20206597]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:22505030]" /experiment="EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:18812321]" /experiment="EXISTENCE:mutant phenotype:GO:0072665 protein localization to vacuole [PMID:29444958]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579]" /experiment="EXISTENCE:mutant phenotype:GO:1900182 positive regulation of protein localization to nucleus [PMID:11733065|PMID:11598205]" /experiment="EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23358411]" /note="Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transcription factors by regulated Ub/proteasome-dependent processing (RUP)" /db_xref="GeneID:852939" /db_xref="SGD:S000003280" ORIGIN 1 mfsgfssfgg gngfvnmpqt feeffrcypi ammndrirkd danfggkifl ppsalsklsm 61 lnirypmlfk ltanetgrvt hggvlefiae egrvylpqwm metlgiqpgs llqisstdvp 121 lgqfvklepq svdfldisdp kavlenvlrn fstltvddvi eisyngktfk ikilevkpes 181 ssksicviet dlvtdfappv gyvepdykal kaqqdkekkn sfgkgqvldp svlgqgsmst 241 ridyagians srnklskfvg qgqnisgkap kaepkqdikd mkitfdgepa kldlpegqlf 301 fgfpmvlpke deesaagsks seqnfqgqgi slrksnkrkt ksdhdssksk apkspeviei 361 d // LOCUS NP_011563 187 aa linear PLN 30-JUN-2025 DEFINITION Scm4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011563 VERSION NP_011563.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181178.1 REFERENCE 1 (residues 1 to 187) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 187) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 187) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 187) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08147. Method: conceptual translation. FEATURES Location/Qualifiers source 1..187 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..187 /product="Scm4p" /calculated_mol_wt="19987" CDS 1..187 /gene="SCM4" /locus_tag="YGR049W" /coded_by="NM_001181178.1:1..564" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /note="Mitochondrial outer membrane hypothetical protein; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation; SCM4 has a paralog, ATG33, that arose from the whole genome duplication" /db_xref="GeneID:852940" /db_xref="SGD:S000003281" ORIGIN 1 mqvspaivkg iavsslglya giltsstvis ittpinvltq hlknvlctlg cwstvlggla 61 tgafglsyyl aapgerpnyl lcglgvapls aaylylvslf nhklapkctr dqndlekqkd 121 eklpqhhpev kdgeaacpfs kmnnaktlkp esersvkchs ymslhmsivt gitiftfgkc 181 ildgfka // LOCUS NP_001257677 118 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR050C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257677 VERSION NP_001257677.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270748.1 REFERENCE 1 (residues 1 to 118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 118) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35111. Method: conceptual translation. FEATURES Location/Qualifiers source 1..118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..118 /product="uncharacterized protein" /calculated_mol_wt="13379" CDS 1..118 /locus_tag="YGR050C" /coded_by="NM_001270748.1:1..357" /note="hypothetical protein; mRNA identified as translated by ribosome profiling data" /db_xref="GeneID:852941" /db_xref="SGD:S000003282" ORIGIN 1 mktnlissfa frphvrfgfl dfgyslksil dvtsqyhfip iklayglcdp llivypdpsf 61 slaqaagekk kvvfptyedv pkllltfkqi mntyrkgslg qrqrqrvygr ngneshst // LOCUS NP_011566 369 aa linear PLN 30-JUN-2025 DEFINITION protein kinase FMP48 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011566 VERSION NP_011566.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181181.1 REFERENCE 1 (residues 1 to 369) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 369) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 369) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 369) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08148. Method: conceptual translation. FEATURES Location/Qualifiers source 1..369 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..369 /product="protein kinase FMP48" /EC_number="2.7.11.1" /calculated_mol_wt="42692" Region 2..>223 /region_name="S_TKc" /note="Serine/Threonine protein kinases, catalytic domain; smart00220" /db_xref="CDD:214567" Site order(8..11,14,16,29,31,63,79..82,133,137..138,140, 150..151) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..369 /gene="FMP48" /locus_tag="YGR052W" /coded_by="NM_001181181.1:1..1110" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation" /db_xref="GeneID:852943" /db_xref="SGD:S000003284" ORIGIN 1 mytklrsiqs gtfstvykaw stthnryval kitpkyktse anmkneydvm kilsscnphp 61 nicsmldfyt ddsyyimvle ycecgdlydf ldiaksqgsp sspsliqidm qkiikqlcsa 121 isfahslgia hrdikpenil ltingdikla dwghaiqspk sndfqigtdn yrapetfsgr 181 vsnscfkknf drssaplynt yqadywslga tifylmfgdc lfrvskskkv qhlknfdefe 241 kdpfafiyrk yvvprlscgy ndeedlhvsl qhtrqyiwqd lpdiydvfhl ckimvdtllk 301 vsnakersme nfinevdsaw nkdssmdscf syqnkidlfw eqwsvntetv pakfqlknfe 361 kpcliqdgk // LOCUS NP_011567 283 aa linear PLN 30-JUN-2025 DEFINITION Mco32p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011567 VERSION NP_011567.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181182.3 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08149. On Jul 30, 2012 this sequence version replaced NP_011567.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..283 /product="Mco32p" /calculated_mol_wt="32069" Region 44..267 /region_name="MMU163" /note="Mitochondrial protein up-regulated during meiosis; pfam17119" /db_xref="CDD:407257" CDS 1..283 /gene="MCO32" /locus_tag="YGR053C" /coded_by="NM_001181182.3:1..852" /note="hypothetical protein" /db_xref="GeneID:852944" /db_xref="SGD:S000003285" ORIGIN 1 mllkcvcrag iisikgifpr wysnsqkvan lgqitdylvv kgvpnllqkm fkesvladnv 61 vfrlfptshp yipvlhgksk ymaslnamrm ivrkfilgde crlhissvkt ltstshdeev 121 ksalqsynti tcndklvikw qscipedhck itkleindrl keekrgngag gsfsmrsvpv 181 idyilhptan nlnqsvisey lenaaersme nkvnetqnsk edekkkndgd gkrskkkrls 241 rlikgtfife fneenskilv htiedvelih yekkiatrga fac // LOCUS NP_011568 642 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor 2A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011568 VERSION NP_011568.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181183.4 REFERENCE 1 (residues 1 to 642) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 642) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 642) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 642) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08150. On Jul 30, 2012 this sequence version replaced NP_011568.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..642 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..642 /product="translation initiation factor 2A" /calculated_mol_wt="71174" Region 1..637 /region_name="COG5354" /note="Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]" /db_xref="CDD:227657" Region 235..281 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 295..331 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 336..375 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..642 /locus_tag="YGR054W" /coded_by="NM_001181183.4:1..1929" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:12133843]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:12133843]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:12133843]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:12133843]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:12133843]" /experiment="EXISTENCE:mutant phenotype:GO:0017148 negative regulation of translation [PMID:38011112]" /note="Eukaryotic initiation factor eIF2A; associates specifically with both 40S subunits and 80S ribosomes, and interacts genetically with both eIF5b and eIF4E; physically interacts with Ssd1p, and associates with mRNAs encoding proteins required for cell wall organization, and some of which require the presence of Ssd1p; translational repressor of cell wall-related proteins; interacts physically and genetically with Xrn1p; homologous to mammalian eIF2A" /db_xref="GeneID:852945" /db_xref="SGD:S000003286" ORIGIN 1 mssqfflkts qdielfqsyp tfeqsntnsk dfpvissvls pcgrflalst kenvkvftgp 61 cldnvlltmk lsdvydlhfs pagnylstwe rasiqdpnhk nvkvwylnkp fkkdcvsedi 121 vpayeyqaks qsgwflqfsk ldnyglrlfk hdlkivklss anadnfdfqs pfavlsddet 181 sqhfttylis paehptictf tpekggkpaq liiwalsegk itkkiasktf fkadscqlkw 241 nplgnailcl aitdfdssnk syygentlyl lsfqgvngtl ggnsvrvslt tgpvhdftws 301 ptsrqfgvia gympatisff dlrgnvvhsl pqqakntmlf spsghyilia gfgnlqgsve 361 ildrldkfkc vskfdatnts vckwspggef imtattsprl rvdngvkiwh vsgslvfvke 421 fkellkvdwr spcnyktlen kdeaffenhi innweplpds ttssldpkis nkselqihss 481 vqeyisqhps reassngngs kakaggaykp pharrtgggr ivpgvppgaa kktipglvpg 541 msankdantk nrrrrankks setspdstpa psapastnap tnnketspee kkirsllkkl 601 raietlkerq avgdkledtq vlkiqteekv lkdleklgwk de // LOCUS NP_011569 574 aa linear PLN 30-JUN-2025 DEFINITION Mup1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011569 VERSION NP_011569.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181184.1 REFERENCE 1 (residues 1 to 574) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 574) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 574) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 574) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08151. Method: conceptual translation. FEATURES Location/Qualifiers source 1..574 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..574 /product="Mup1p" /calculated_mol_wt="63090" Region 1..541 /region_name="2A0308" /note="L-type amino acid transporter; TIGR00911" /db_xref="CDD:273332" CDS 1..574 /gene="MUP1" /locus_tag="YGR055W" /coded_by="NM_001181184.1:1..1725" /experiment="EXISTENCE:direct assay:GO:0000102 L-methionine secondary active transmembrane transporter activity [PMID:8893857]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25942624]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:1903692 methionine import across plasma membrane [PMID:8893857]" /experiment="EXISTENCE:mutant phenotype:GO:0000101 sulfur amino acid transport [PMID:8893857]" /experiment="EXISTENCE:mutant phenotype:GO:1903692 methionine import across plasma membrane [PMID:8893857]" /note="High affinity methionine permease; integral membrane protein with 13 putative membrane-spanning regions; involved in both methionine and cysteine uptake; subject to transport-activity dependent, methionine-induced endocytosis, vacuolar delivery and degradation; starvation-induced endocytosis is transport-activity independent" /db_xref="GeneID:852946" /db_xref="SGD:S000003287" ORIGIN 1 msegrtflsq lnvfnkenyq fsssttkkev snstvdadng asdfeagqqf ateldqgekq 61 lgilscigli cnrmlgtgvf avsstiytlc gsvglalimw avgaiiaisg lyvymefgta 121 ipknggekny leaifrkpkf fitcmyaayi fflgwaagns intaimflta adtevtkwnq 181 rgigvavvff aflinslnvk iglylqnilg ifkigivlfi sitgwvalgg glkdgyqshn 241 frnafegtet ataygivnal ysviwsfvgy snvnyalgev knpvrtlkia gptsmvflai 301 iyifvniayf avvpkdklis sklilaadff divfggqakr aaaalvglsa lgnvlsvifs 361 qgriiqqlgr egvlpfsnff asskpfnspm vglfqhfivc tvtilapppg dayllvqnli 421 sypmniinfa isagllwiyw qrrqgkiewn ppikagvfvt gfftlsnlyl iiapyvppsn 481 gesvyssmpy wihcviawgi fffggvyyvv waqllprwgh yklvskdvlg edgfwrvkia 541 kvyddtigdv dtqedgviet niiehykseq eksl // LOCUS NP_011570 928 aa linear PLN 30-JUN-2025 DEFINITION RSC subunit protein RSC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011570 VERSION NP_011570.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181185.1 REFERENCE 1 (residues 1 to 928) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 928) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 928) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 928) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08152. Method: conceptual translation. FEATURES Location/Qualifiers source 1..928 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..928 /product="RSC subunit protein RSC1" /calculated_mol_wt="106539" Region 8..113 /region_name="Bromo_Rsc1_2_I" /note="Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two...; cd05521" /db_xref="CDD:99952" Site order(39,44,47,84,88,94) /site_type="other" /note="putative acetyllysine binding site [chemical binding]" /db_xref="CDD:99952" Region 115..463 /region_name="COG5076" /note="Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]" /db_xref="CDD:227408" CDS 1..928 /gene="RSC1" /locus_tag="YGR056W" /coded_by="NM_001181185.1:1..2787" /experiment="EXISTENCE:curator inference:GO:0008094 ATP-dependent activity, acting on DNA [PMID:10619019]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16024655]" /experiment="EXISTENCE:physical interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15870268]" /note="Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook; RSC1 has a paralog, RSC2, that arose from the whole genome duplication" /db_xref="GeneID:852947" /db_xref="SGD:S000003288" ORIGIN 1 mveqdngflq kllktqydav fhlkdengie iypifnvlpp kkeypdyyii irnpislntl 61 kkrlphytsp qdfvndfaqi pwnamtynak dsviykyail lesfikgkiv hnirkhypev 121 typslgripe ifaesmqpsd lssnpintqe ndekaglnpe mkmafaklds siterkptnq 181 dyrmqqknsp afpthsasit pqplasptpv vnyanitsah pkthvrrgrp pvidlpyvlr 241 iknilkmmrr evdqnnktlt lcfeklpdrn eeptyysvit dpiclmdirk kvksrkyrnf 301 htfeedfqlm ltnfklyysq dqsniiraql leknfnrlvr ielskpdedy lpegelrypl 361 ddveindeky qigdwvllhn pndinkpivg qifrlwsttd gnkwlnacwy frpeqtvhrv 421 drlfyknevm ktgqyrdhpi qdikgkcyvi hftrfqrgdp stkvngpqfv cefrynesdk 481 vfnkirtwka clpeelrdqd eptipvngrk ffkypspiad llpanatlnd kvpeptegap 541 tapplvgavy lgpklerddl geystsddcp ryiirpndpp eegkidyetg tiitdtltts 601 smprvnssst irlptlkqtk sipssnfrss sntpllhqnf nqtsnflkle nmnnsshnll 661 shpsvpkfqs pslleqssrs kyhsakkqtq lsstapkkpa sksftlssmi ntltahtsky 721 nfnhivieap gafvvpvpme knirtiqste rfsrsnlkna qnlgntaind intaneqiiw 781 fkgpgvkite rvidsgndlv rvplnrwfck nkrrkldyed ieedvmeppn dfsedmiani 841 fnpppslnld mdlnlspssn nssnfmdlst iasgdndgke cdtaeesede nedtedehei 901 edipttsafg lnssaeylaf rlrefnkl // LOCUS NP_011571 242 aa linear PLN 30-JUN-2025 DEFINITION Lst7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011571 VERSION NP_011571.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181186.3 REFERENCE 1 (residues 1 to 242) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 242) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 242) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 242) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08153. On Jul 30, 2012 this sequence version replaced NP_011571.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..242 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..242 /product="Lst7p" /calculated_mol_wt="28005" Region 70..235 /region_name="Folliculin" /note="Vesicle coat protein involved in Golgi to plasma membrane transport; pfam11704" /db_xref="CDD:463323" CDS 1..242 /gene="LST7" /locus_tag="YGR057C" /coded_by="NM_001181186.3:1..729" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:26387955]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26387955]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:26387955]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990877 FNIP-folliculin RagC/D GAP [PMID:26387955]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:26387955]" /experiment="EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:26387955]" /note="Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface" /db_xref="GeneID:852948" /db_xref="SGD:S000003289" ORIGIN 1 msstvislah fcdkhgprii svtqsaekgt lgeellvpdy ptesycescl lqfpeestrs 61 mrcfiedvpf ittqyssiry qllnsiikra fseetmiydn mpfiffddlr glnlvigfkl 121 ydenargner rycfiltvds rshddsmkml sehwnfiigg fdkmiayikn ihkseflgkn 181 ktvennletl nnnafigsyl rankskfgrn lvsltddkfl fvrihkwnsf llhtvmnenk 241 lp // LOCUS NP_011572 335 aa linear PLN 30-JUN-2025 DEFINITION Pef1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011572 VERSION NP_011572.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181187.2 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08154. On Apr 26, 2011 this sequence version replaced NP_011572.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..335 /product="Pef1p" /calculated_mol_wt="38211" Region 161..329 /region_name="EFh_PEF_Group_I" /note="Penta-EF hand, calcium binding motifs, found in Group I PEF proteins; cd16180" /db_xref="CDD:320055" Region 161..190 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320055" Site order(170,172,174,181,237,239,241,248,308,310,312) /site_type="other" /note="Ca binding site [ion binding]" /db_xref="CDD:320055" Region 198..227 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320055" Region 228..257 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320055" Site order(264,267..268,271,297,300..301,303..304,313..320, 322..323,326..327) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:320055" Region 264..298 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320055" Region 299..329 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320055" CDS 1..335 /gene="PEF1" /locus_tag="YGR058W" /coded_by="NM_001181187.2:1..1008" /experiment="EXISTENCE:direct assay:GO:0003400 regulation of COPII vesicle coating [PMID:22792405]" /experiment="EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:17640275]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22792405]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17640275]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:17640275]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:17640275]" /experiment="EXISTENCE:mutant phenotype:GO:0003400 regulation of COPII vesicle coating [PMID:22792405]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:17640275]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:17640275]" /experiment="EXISTENCE:physical interaction:GO:0003400 regulation of COPII vesicle coating [PMID:22792405]" /note="Penta-EF-hand protein; required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly" /db_xref="GeneID:852949" /db_xref="SGD:S000003290" ORIGIN 1 mcakklkyaa gddfvryatp keameetrre fekekqrqqq ikvtqaqtpn trvhsapipl 61 qtqynknrae nghhsygspq sysprhtktp vdprynviaq kpagrpippa pthynnlnts 121 aqriassppp lihnqavpaq llkkvapasf dsredvrdmq vatqlfhnhd vkgknrltae 181 elqnllqndd nshfcissvd alinlfgasr fgtvnqaefi alykrvkswr kvyvdnding 241 sltisvsefh nslqelgyli pfevsektfd qyaefinrng tgkelkfdkf vealvwlmrl 301 tklfrkfdtn qegiatiqyk dfidatlylg rflph // LOCUS NP_011573 512 aa linear PLN 30-JUN-2025 DEFINITION septin SPR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011573 VERSION NP_011573.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181188.3 REFERENCE 1 (residues 1 to 512) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 512) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 512) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 512) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 512) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08155. On Jul 30, 2012 this sequence version replaced NP_011573.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..512 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..512 /product="septin SPR3" /calculated_mol_wt="59714" Region 107..365 /region_name="Septin" /note="pfam00735" /db_xref="CDD:395596" Site 116..123 /site_type="other" /note="G1 box" /db_xref="CDD:206649" Site order(118..124,165,168,246..247,249,299..300) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206649" Site 140..148 /site_type="other" /note="Switch I region" /db_xref="CDD:206649" Site 142 /site_type="other" /note="G2 box" /db_xref="CDD:206649" Site 165..168 /site_type="other" /note="G3 box" /db_xref="CDD:206649" Site order(167..202,203..212) /site_type="other" /note="Switch II region" /db_xref="CDD:206649" Site 246..249 /site_type="other" /note="G4 box" /db_xref="CDD:206649" Site 299..301 /site_type="other" /note="G5 box" /db_xref="CDD:206649" CDS 1..512 /gene="SPR3" /locus_tag="YGR059W" /coded_by="NM_001181188.3:1..1539" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:8636217]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18826657]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0031105 septin complex [PMID:24390141|PMID:18826657]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:8636217]" /note="Sporulation-specific homolog of the CDC3/10/11/12 family of genes; septin protein involved in sporulation; regulated by ABFI; the yeast CDC3/10/11/12 family is a family of bud neck microfilament genes" /db_xref="GeneID:852950" /db_xref="SGD:S000003291" ORIGIN 1 mkskgsrlst dcpvefpkiv sgfaeevkir rqssqgqyav dshppkspel khrrqrsssf 61 vngkcrnrdl plldnkkaqe intnshgqdi giknlprqre llnakngidf tlmvagqsgl 121 gkttfinslf stslidddik enkpiiryks ivegdgthln fnvidtpgfg nnmdnaftwr 181 tmvnyideei rsyifqeeqp drtkmvdnrv hcclyflrps nkgidtldvv tmkklakrvn 241 lipviaksdl ltkeelknfk tqvreiirvq dipvcfffgd evlnatqdif qkypfsiias 301 neyifnekge kvkgrqykwg avdienekyc dfkilqktif dwnlidlves tedyyekcrs 361 emlrtrllka rdclttksvd iteeqrkfle eemnfdeiee nklknykcye iinktvmdkv 421 atewdpefit rqleakkkfn elsnreiskf rdwkkslfme qenfnqeieq lnhklenlql 481 ecqdleykll igkssnshst dsatlvnvhi kr // LOCUS NP_011574 309 aa linear PLN 30-JUN-2025 DEFINITION methylsterol monooxygenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011574 VERSION NP_011574.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181189.3 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08156. On Jul 30, 2012 this sequence version replaced NP_011574.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..309 /product="methylsterol monooxygenase" /calculated_mol_wt="36348" Region 147..282 /region_name="FA_hydroxylase" /note="Fatty acid hydroxylase; pfam04116" /db_xref="CDD:397991" CDS 1..309 /gene="ERG25" /locus_tag="YGR060W" /coded_by="NM_001181189.3:1..930" /experiment="EXISTENCE:direct assay:GO:0000254 C-4 methylsterol oxidase activity [PMID:12880870|PMID:8663358]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8663358]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8663358]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:12880870|PMID:8663358]" /experiment="EXISTENCE:mutant phenotype:GO:0000254 C-4 methylsterol oxidase activity [PMID:8552601]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:8552601]" /experiment="EXISTENCE:physical interaction:GO:0005783 endoplasmic reticulum [PMID:12119386]" /note="C-4 methyl sterol oxidase; catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol; human MSMO1 functionally complements the growth defect caused by repression of ERG25 expression" /db_xref="GeneID:852951" /db_xref="SGD:S000003292" ORIGIN 1 msavfnnatl sglvqastys qtlqnvahyq pqlnfmekyw aawysymnnd vlatglmffl 61 lhefmyffrc lpwfiidqip yfrrwklqpt kipsakeqly clksvllshf lveaipiwtf 121 hpmceklgit vevpfpslkt maleiglffv ledtwhywah rlfhygvfyk yihkqhhrya 181 apfglsaeya hpaetlslgf gtvgmpilyv mytgklhlft lcvwitlrlf qavdshsgyd 241 fpwslnkimp fwagaehhdl hhhyfignya ssfrwwdycl dtesgpeaka sreermkkra 301 ennaqkktn // LOCUS NP_011575 1358 aa linear PLN 30-JUN-2025 DEFINITION phosphoribosylformylglycinamidine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011575 VERSION NP_011575.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181190.1 REFERENCE 1 (residues 1 to 1358) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1358) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1358) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1358) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08157. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1358 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1358 /product="phosphoribosylformylglycinamidine synthase" /EC_number="6.3.5.3" /calculated_mol_wt="148775" Region 5..1358 /region_name="PRK05297" /note="phosphoribosylformylglycinamidine synthase; Provisional" /db_xref="CDD:235394" CDS 1..1358 /gene="ADE6" /locus_tag="YGR061C" /coded_by="NM_001181190.1:1..4077" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004642 phosphoribosylformylglycinamidine synthase activity [PMID:9331966]" /experiment="EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:1743513]" /note="Formylglycinamidine-ribonucleotide (FGAM)-synthetase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway" /db_xref="GeneID:852952" /db_xref="SGD:S000003293" ORIGIN 1 mtdyilpgpk alsqfrvdnl ikdinsytns tsvinelrsc yihyvngiaq nlseqdtkll 61 evlltydsal diandplarq lndavannlp ssalgedtyl irvvprsgti spwsskatni 121 ahvcglqdkv qrierglall iktvpgfpll enlndislkc vydrmtqqly lteppntmsi 181 ftheepkplv hvpltpkdtk qspkdilska ntelglalds gemeylihaf vetmkrdptd 241 velfmfaqvn sehcrhkifn adwtidgikq qftlfqmirn thklnpeyti saysdnaavl 301 dsendafffa pnsttkewts tkeripllik vethnhptav spfpgaatgs ggeirdegat 361 grgsktkcgl sgfsvsdlli pgneqpweln igkpyhiasa ldimieaplg saafnnefgr 421 pcingyfrtl ttkvlnhqgk eeirgfhkpi miaggfgtvr pqfalkntpi tpgsclivlg 481 gqsmliglgg gaassvasge gsadldfasv qrgnpemerr cqqvidacva lgnnnpiqsi 541 hdvgagglsn alpelvhdnd lgakfdirkv lslepgmspm eiwcnesqer yvlgvspqdl 601 sifeeickre rapfavvgha taeqklived pllkttpidl empilfgkpp kmsretitea 661 lnlpeanlse ipslqdaiqr vlnlpsvgsk sflitigdrs vtglidrdqf vgpwqvpvad 721 vgvtgtslge tiistgeama mgekpvnali sasasaklsv aesllnifaa dvkslnhikl 781 sanwmspash qgegsklyea vqalgldlcp algvaipvgk dsmsmkmkwd dkevtaplsl 841 nitafapvfn tsktwtplln rntddsvlvl vdlsakqetk slgasallqv ynqvgnkspt 901 vydnailkgf lesliqlhqq kedivlayhd rsdggllitl lemafasrcg leinidggdl 961 esqltnlfne elgavfqisa knlskfekil nengvakeyi sivgkpsfqs qeikiinstt 1021 ndviyansrs eleqtwskts yemqklrdnp ktaeeefasi tddrdpglqy altynpaddm 1081 kiglelssqr pkvailreqg vngqmemawc fqqagfnsvd vtmtdllegr fhlddfigla 1141 acggfsygdv lgagagwaks vlyhegvrsq fskffnerqd tfafgacngc qflsrlkdii 1201 pgcenwpsfe rnvseqyear vcmvqisqek dnsseesvfl ngmagsklpi avahgegkat 1261 fsksaeqlek fekdglccir yvdnygnvte rfpfnpngst ngiagikspn grvlammphp 1321 ervcrleans wypegkyeew ggygpwirlf rsarrwvg // LOCUS NP_011576 316 aa linear PLN 30-JUN-2025 DEFINITION membrane insertase COX18 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011576 VERSION NP_011576.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181191.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08158. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..316 /product="membrane insertase COX18" /calculated_mol_wt="35519" Region 53..310 /region_name="5TM_Oxa1-like" /note="Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; cd20069" /db_xref="CDD:410993" CDS 1..316 /gene="COX18" /locus_tag="YGR062C" /gene_synonym="OXA2" /coded_by="NM_001181191.1:1..951" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11950926]" /experiment="EXISTENCE:genetic interaction:GO:0032977 membrane insertase activity [PMID:17922846]" /experiment="EXISTENCE:genetic interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11950926|PMID:17922846]" /experiment="EXISTENCE:mutant phenotype:GO:0032977 membrane insertase activity [PMID:11950926]" /experiment="EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11950926]" /experiment="EXISTENCE:physical interaction:GO:0032977 membrane insertase activity [PMID:17452441]" /experiment="EXISTENCE:physical interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:17452441]" /note="Protein required for membrane insertion of C-terminus of Cox2p; mitochondrial integral inner membrane protein; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC; respiratory defect of the null mutant is functionally complemented by human COX18 carrying the N-terminal 54 amino acids of S. cerevisiae Cox18p" /db_xref="GeneID:852953" /db_xref="SGD:S000003294" ORIGIN 1 mlkrlanrqn gfasfscssv glrygrtnps tkrsfslfqs vadtfltvhe ashipwivlv 61 plttmtlrtl vtlpfsiwqr rrilkqqelr klvqpitpii klrlaavtnk ksrnaariss 121 ngsfmplqlq nagvltpeqi tllavketrk rqkklfkkyn vplwknallp mvqiplwvtv 181 smgirtltet qliesfypsw fsalgfssfd lssplvampl lapilvgtla vlnvelngrl 241 mfssslssqg iktisrnstr vqeamtsiln vsrlgcvvml amssqapfll slywissqlf 301 slvqniilnw iypyqr // LOCUS NP_011577 102 aa linear PLN 30-JUN-2025 DEFINITION transcription elongation factor SPT4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011577 VERSION NP_011577.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181192.3 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08159. On Jul 30, 2012 this sequence version replaced NP_011577.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..102 /product="transcription elongation factor SPT4" /calculated_mol_wt="11027" Region 1..102 /region_name="SPT4" /note="Transcription elongation factor SPT4 [Transcription]; COG5204" /db_xref="CDD:227530" Site order(7,10,24,27) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:153422" Site order(48..53,58) /site_type="active" /note="Spt4-Spt5NGN interface [active]" /db_xref="CDD:153422" CDS 1..102 /gene="SPT4" /locus_tag="YGR063C" /coded_by="NM_001181192.3:1..309" /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:16908835]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:15057281]" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:26945063]" /experiment="EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:27376968]" /experiment="EXISTENCE:direct assay:GO:0031934 mating-type region heterochromatin [PMID:15057281]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:26945063]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:16908835]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:26945063]" /experiment="EXISTENCE:genetic interaction:GO:0006370 7-methylguanosine mRNA capping [PMID:12556496]" /experiment="EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:20042611]" /experiment="EXISTENCE:genetic interaction:GO:2001208 negative regulation of transcription elongation by RNA polymerase I [PMID:21467039]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:15057281]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:9450930]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:20713510]" /experiment="EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:31462158]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:15057281]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12554661]" /experiment="EXISTENCE:mutant phenotype:GO:2000232 regulation of rRNA processing [PMID:21949810]" /experiment="EXISTENCE:mutant phenotype:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:16908835]" /experiment="EXISTENCE:physical interaction:GO:0032044 DSIF complex [PMID:9450930]" /note="Spt4p/5p (DSIF) transcription elongation factor complex subunit; Spt4/5 binds ssRNA in a sequence-specific manner and along with RNAP I and II regulates transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; localizes to kinetochores and heterochromatin, influencing chromosomal dynamics and silencing; required for transcription through long trinucleotide repeats in ORFs and non-protein coding regions; accelerates senescence through rDNA instability" /db_xref="GeneID:852955" /db_xref="SGD:S000003295" ORIGIN 1 msseracmlc givqttnefn rdgcpncqgi feeagvstme ctspsfeglv gmckptkswv 61 akwlsvdhsi agmyaikvdg rlpaevvell phykprdgsq ve // LOCUS NP_011579 593 aa linear PLN 30-JUN-2025 DEFINITION Vht1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011579 VERSION NP_011579.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181194.1 REFERENCE 1 (residues 1 to 593) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 593) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 593) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 593) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08160. Method: conceptual translation. FEATURES Location/Qualifiers source 1..593 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..593 /product="Vht1p" /calculated_mol_wt="68952" Region 124..542 /region_name="MFS_FEN2_like" /note="Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; cd17327" /db_xref="CDD:340885" Site order(140..141,144..145,148,181,231..232,234..236,239,259, 262..263,266,375,378..379,382..384,387,415,419,469..470, 474,478,496,499..500,503..504,507) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340885" CDS 1..593 /gene="VHT1" /locus_tag="YGR065C" /coded_by="NM_001181194.1:1..1782" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10373489]" /experiment="EXISTENCE:direct assay:GO:0015225 biotin transmembrane transporter activity [PMID:10373489]" /experiment="EXISTENCE:direct assay:GO:0015878 biotin transport [PMID:10373489]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin" /db_xref="GeneID:852956" /db_xref="SGD:S000003297" ORIGIN 1 mtisnkswrs yfphlrklpe ddqylysddt nssiiaeeel hhsvdksskt dvtaettave 61 phphnlrhdl pyevrdeagr kwwkyfdefe yrvnkeykks rkwyeflypn httqtkaerr 121 llykldiiia lyffmlcwsk svdlnnytna yvsnmkedln mkgndyvyts tianvgaivf 181 qlpfmyllpr fpshiilpvm dlgwtwftfa cyranslael rayrfilsaf gaayypvsqy 241 ilgcwyapde insrvclffc gqqlgsvtsg llqsrifksl ngvhglagwr wmflidaiai 301 slptaiigff vipgvpskcy slfltdeeir iararnkrnq ikdgvdkskl aplwsrklwk 361 kvfctpafwv lvvfdtcswn nmtaysgsyt lwlksntkys iaqvnnlsvi paclgfayvi 421 fcafgadlfr ckwifmvfaa imntvscall ikwdipskak wyaffttyfs vaaspclwsf 481 indflrfdpq vkaitwiaiy sfsqstyawi ptlawptves prfktgytvs lifgaiyglw 541 tfvvlffykr nekkhalgng iilydsnkge elpefvkknm eerdgyyylk rss // LOCUS NP_011580 292 aa linear PLN 30-JUN-2025 DEFINITION Gid10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011580 VERSION NP_011580.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181195.3 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08161. On Jul 30, 2012 this sequence version replaced NP_011580.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..292 /product="Gid10p" /calculated_mol_wt="33917" Region 1..288 /region_name="VID24" /note="Vacuolar import and degradation protein [Intracellular trafficking and secretion]; COG5073" /db_xref="CDD:227405" CDS 1..292 /gene="GID10" /locus_tag="YGR066C" /coded_by="NM_001181195.3:1..879" /experiment="EXISTENCE:direct assay:GO:0006970 response to osmotic stress [PMID:31337681]" /experiment="EXISTENCE:direct assay:GO:0030163 protein catabolic process [PMID:31337681]" /experiment="EXISTENCE:direct assay:GO:0034657 GID complex [PMID:31337681]" /experiment="EXISTENCE:direct assay:GO:0042594 response to starvation [PMID:31337681]" /note="Recognition component (N-recognin) of the Pro/N-degron pathway; recognizes and targets for degradation proteins with N-terminal degradation signals; expressed only under starvation or osmotic stress" /db_xref="GeneID:852957" /db_xref="SGD:S000003298" ORIGIN 1 mtslnimgrk filerakrnd nieeiytsay vslpsstdtr lphfkakeed cdvyeegtnl 61 vgknakytyr slgrhldflr pglrfggsqs skytyytvev kidtvnlply kdsrsldphv 121 tgtftiknlt pvldkvvtlf egyvinynqf plcslhwpae etldpymaqr esdcshwkrf 181 ghfgsdnwsl ternfgqynh esaefmnqry iylkwkerfl lddeeqenlm lddnhhlega 241 sfegfyyvcl dqltgsvegy yyhpacelfq klelvptncd alntyssgfe ia // LOCUS NP_011581 804 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR067C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011581 VERSION NP_011581.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181196.4 REFERENCE 1 (residues 1 to 804) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 804) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 804) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 804) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 804) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 804) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 804) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 804) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08162. On Jul 30, 2012 this sequence version replaced NP_011581.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..804 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..804 /product="uncharacterized protein" /calculated_mol_wt="92119" Region 10..30 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 36..57 /region_name="zf-C2H2" /note="Zinc finger, C2H2 type; pfam00096" /db_xref="CDD:395048" Region 38..57 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..804 /locus_tag="YGR067C" /coded_by="NM_001181196.4:1..2415" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]" /note="hypothetical protein; contains a zinc finger motif similar to that of Adr1p" /db_xref="GeneID:852958" /db_xref="SGD:S000003299" ORIGIN 1 maagqkkyic sfclkpfsrs ehkirhersh agvkpfqcqv ckhsfvrrdl lqrhirtvhr 61 tfllssyasm tgdkadipvs lgvgdvdsts prdikmetlv nsmikvnsgl inihyhssnv 121 ekmdkqqrcv igkessslkk gksrfkqvks rlessisvki lqeysldfis srdiltffrm 181 gvshlvenki fqnffpdlfs slqndelves fwinkpfgli iaclgmsisl nqdsqklwfi 241 cctnlyasss khdndfdted ilsqteqhdv falilfysll vmlennipvs nsikkfdvfs 301 mlqdilkpft vasssyhyln skenawfifd lwvnilrdsn nfnndsllif gwfvnqefis 361 snplkdfiyk gpsmsttdlt lkhinilads ayvyfiikkt ypqelpsdfr vhdllvylne 421 cfvmqqpikp etsanpslfa nvmnaritdc ksksnwllwe tiwfefinnl tlrngttrni 481 wfidnfpqvs tscllhhsss fvdetlittn lsiismllnl ksftlaslnp rniqlitdiv 541 sfqlklfsse liassdvsps qvsqllvnpn vhlmlyfwfd tiyvqrqsyl sstekeefek 601 vevfvndyii thqknlvtdl hsilfdfwsd sfiayhillh aivsslrdni lypyliysph 661 lndqtkallt disnwscfal qqpfrktsrg slsgasdmks fsvasclpls pnflkrdsnc 721 nkillppldi kaiepistsn ytyvnsapkq qekeqpllra tgnninlvqt ivvppqvnme 781 sqefsasstd nkqsknieif sqik // LOCUS NP_011582 586 aa linear PLN 30-JUN-2025 DEFINITION Art5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011582 VERSION NP_011582.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181197.1 REFERENCE 1 (residues 1 to 586) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 586) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 586) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 586) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08163. Method: conceptual translation. FEATURES Location/Qualifiers source 1..586 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..586 /product="Art5p" /calculated_mol_wt="65346" Region 332..475 /region_name="Arrestin_C" /note="Arrestin (or S-antigen), C-terminal domain; pfam02752" /db_xref="CDD:460676" CDS 1..586 /gene="ART5" /locus_tag="YGR068C" /coded_by="NM_001181197.1:1..1761" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]" /note="Protein proposed to regulate endocytosis of plasma membrane proteins; regulates by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; SWAT-GFP and mCherry fusion proteins localize to the cytosol" /db_xref="GeneID:852960" /db_xref="SGD:S000003300" ORIGIN 1 mfslsslsss gghseqkere risyfdirin spykdiiliq gsplelssip lsgnlvisvk 61 neivvkkisl rlvgrfklef lqvgrykkns sslaslvkek rkifecywdn llvsskgdvl 121 vggenaenqh nsssgrstsn qdmdtsgnai flskrslssp vfnkiirrkt hsshrkilel 181 pengvtgtpf eglrenarsr ssssntlnnn shsysnrdgs gssylflmkr gnyelpfntm 241 lppevcetie glqsgsilys feaiidgrql wdtdlsvhts phgpigstst sgngmrtknk 301 iiikkfkylr ilrtlsmdnl amqeeisvgn twrdklqyet sipsravpig sttpvkikif 361 pfeknirldr iemaliqyya mkdssaqiyd deiavmkith ladfgpltdk ldvdcpftip 421 dnlkqitqdc clqdnlirvm hklqvrillq rqvdgeyknl eikaqlpmll fisphlpmkg 481 rlvlfdkhdg kihfrpgelv plflttypaq gltpgvelns tttahlalpq pppnyhestn 541 dhlmpalqpl gadsvvltvp syeqaqaqas assyvtgsvp aycddd // LOCUS NP_011584 1155 aa linear PLN 30-JUN-2025 DEFINITION Rho family guanine nucleotide exchange factor ROM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011584 VERSION NP_011584.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181199.2 REFERENCE 1 (residues 1 to 1155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1155) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08164. On Apr 26, 2011 this sequence version replaced NP_011584.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1155 /product="Rho family guanine nucleotide exchange factor ROM1" /calculated_mol_wt="131289" Region 1..1155 /region_name="ROM1" /note="RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]; COG5422" /db_xref="CDD:227709" CDS 1..1155 /gene="ROM1" /locus_tag="YGR070W" /gene_synonym="SKC1" /coded_by="NM_001181199.2:1..3468" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22065638]" /experiment="EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8641285]" /experiment="EXISTENCE:genetic interaction:GO:0007264 small GTPase-mediated signal transduction [PMID:8641285]" /note="Guanine nucleotide exchange factor (GEF) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP; ROM1 has a paralog, ROM2, that arose from the whole genome duplication" /db_xref="GeneID:852961" /db_xref="SGD:S000003302" ORIGIN 1 mnsneldlrn kyfyeifgkk rksdtstptq lfsgskvqtn ineisitnde dedstedenk 61 aslkdytlgh dtgaryriap dcsshqlkas pvlhistnln sspqsftgdq isptnkkisi 121 ndstrqdkgn sctttsspsq krsnvllphv rkhsspslls fsknsgshmg dpnqlstppt 181 pksaghtmel hssfngkhss sstsslfale slktqnrrss nssnhssqyr rhtnqhqrhh 241 srsksspvsl teismikgtp lvypallsli aikfkqtikl sthkkmglly rdsftgkqai 301 dtlcliigsl drnlgmligk sleaqklfhd vlydhgvrds vleiyelsse sifmahqsqs 361 stsiantfss ssssvnslrt kteiygvfvp lthcysstcs leklcysisc pnrlqqqanl 421 hlklggglkr nislaldked deriswtnsv pksvweslsk qqikrqeaiy elfttekkfv 481 ksleiirdtf mkklletnii psdvrinfvk hvfahineiy svnreflkal aqrqslspic 541 pgiadiflqy lpffdpflsy iasrpyakyl ietqrsvnpn farfddevsn sslrhgidsf 601 lsqgvsrpgr ysllvreiih fsdpvtdkdd lqmlmkvqdl lkdlmkridr asgaaqdryd 661 vkvlkqkilf kneyvnlgln nekrkikheg llsrkdvnkt dasfsgdiqf ylldnmllfl 721 kskavnkwhq htvfqrpipl pllficpaed mppikryvte npncsagvll pqyqtsnpkn 781 aivfayygtk qqyqvtlyap qpaglqtlie kvkqeqkrll detkhitfkq mvgqffhsyi 841 ntnrvndvli chagkillva tnmglfvlny atsinqkpvh llhkisisqi svleeykvmi 901 llidkklygc pldviddaen adflfrknsk vlfkyvamfk dgfcngkrii miahhflhav 961 qllivnplif dfnsgnfkkn lkaglvdfsv dseplsfsfl enkicigckk nikilnvpev 1021 cdkngfkmre llnlhdnkvl anmyketfkv vsmfpiknst facfpelcff lnkqgkreet 1081 kgcfhwegep eqfacsypyi vainsnfiei rhiengelvr cvlgnkirml ksyakkilyc 1141 yedpqgfeii ellnf // LOCUS NP_011585 860 aa linear PLN 30-JUN-2025 DEFINITION Env11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011585 VERSION NP_011585.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181200.3 REFERENCE 1 (residues 1 to 860) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 860) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 860) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 860) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 860) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 860) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 860) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 860) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08165. On Jul 30, 2012 this sequence version replaced NP_011585.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..860 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..860 /product="Env11p" /calculated_mol_wt="97978" Region 87..132 /region_name="zf-BED" /note="BED zinc finger; pfam02892" /db_xref="CDD:427043" CDS 1..860 /gene="ENV11" /locus_tag="YGR071C" /coded_by="NM_001181200.3:1..2583" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:21912603]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:21912603]" /note="Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; ENV11 has a paralog, VID22, that arose from the whole genome duplication" /db_xref="GeneID:852962" /db_xref="SGD:S000003303" ORIGIN 1 mntalddlhg dlvtlednei innsdhsssh stsheeedee eddtedieli ekdgnkilss 61 rihpedeiin dglniwipvq mlkkniakfw shflaiekkl tkvkckhcge iltrsdaslt 121 ktfrshlktk hnisanknfy smnftvgdsn lknntsstei trrhgydslt fnsdqsfkcf 181 digklqssny lsisqlvaiv iasenlplnf fenvsfksll skfhripplt tniieesiig 241 lsksidelir rsisrndtql pftihlsdsk esnqplylky sreiraqlsn ldlshlisvn 301 ftelagkrsl fslqlfdntn kvskglplsi fvrkttdidi svwqeqlnnl yskypglqks 361 visitlpqsh ytmvlenrns hnftfhsgsv reikyhtciv sellhcflqp lfnvptesml 421 ssfsvakenh sggslldsli dfshidlsst ilgkicclie evnlndslks dfllycqnyt 481 qpncneltsi lscncdrfsa lksilekfan lvpffksins hleneslses dfrlintvee 541 tlrtfeqsie yfassaplkf thtlvfiikf elylteiirs fkftkskkpf ekilarllkv 601 kdlyllddvn ligaflypsi fqsksllnei fgttsvnkiv hnmtkivlry lknfinitnf 661 rssnsggesg rnsgnnllsd yeaifmkesr dvellcntkl tapltedsll vqiirddllr 721 yvnriahelp nayhdylndn disfdgshft khelseends nsgewclnpm eetfdihipi 781 sdsiwnnyis sknkievidi llqllsvnst ssirselssl tanqdfstkl seetikikll 841 nsqfnlekin fhsgsifdac // LOCUS NP_011586 387 aa linear PLN 30-JUN-2025 DEFINITION Upf3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011586 VERSION NP_011586.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181201.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08166. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..387 /product="Upf3p" /calculated_mol_wt="44793" Region 83..264 /region_name="Smg4_UPF3" /note="Smg-4/UPF3 family; pfam03467" /db_xref="CDD:460932" CDS 1..387 /gene="UPF3" /locus_tag="YGR072W" /gene_synonym="SUA6; SUP112" /coded_by="NM_001181201.1:1..1164" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9763508]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12196393]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12196393]" /experiment="EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:18676617]" /experiment="EXISTENCE:physical interaction:GO:0016567 protein ubiquitination [PMID:18676617]" /note="Component of the nonsense-mediated mRNA decay (NMD) pathway; along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance" /db_xref="GeneID:852963" /db_xref="SGD:S000003304" ORIGIN 1 msnvagelkn segkkkgrgn ryhnknrgks knetvdpkkn enkvnnatna thnnskgrrn 61 nkkrnreyyn ykrkarlgks tenegfklvi rllppnltad effailrdnn nddgdkqdiq 121 gklkysdwcf feghysskvf knstysrcnf lfdnlsdlek canfiktckf idnkdnitip 181 dmklspyvkk ftqtskkdaa lvgtieedei fktfmnsmkq lnendeysfq dfsvlkslek 241 efsksielen kiaertervl telvgtgdkv knknkkkknk nakkkfkeee asakipkkkr 301 nrgkkkrenr ekstisktkn snvviieeag kevlkqrkkk mllqeklkis nssqpqsssa 361 qtqpsfqpke nlfvprvkil hrddtkk // LOCUS NP_011588 146 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SMD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011588 VERSION NP_011588.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181203.3 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08167. On Jul 30, 2012 this sequence version replaced NP_011588.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..146 /product="mRNA splicing protein SMD1" /calculated_mol_wt="16144" Region 2..111 /region_name="Sm_like" /note="Sm and related proteins; cl00259" /db_xref="CDD:469694" Site order(12,30,41,84..96) /site_type="other" /note="heptamer interface [polypeptide binding]" /db_xref="CDD:212471" Site order(15..19,23..33,37..41) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212471" Site order(18..19,23,25,31..32,37,39,84..94) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:212471" Site order(36..37,88,90) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:212471" Site 84..95 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212471" CDS 1..146 /gene="SMD1" /locus_tag="YGR074W" /gene_synonym="SPP92" /coded_by="NM_001181203.3:1..441" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284|PMID:11720285]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245|PMID:9012791]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:physical interaction:GO:0000243 commitment complex [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0003729 mRNA binding [PMID:10072386]" /note="Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; relocalizes to the cytosol in response to hypoxia; homolog of human Sm D1; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:852964" /db_xref="SGD:S000003306" ORIGIN 1 mklvnflkkl rneqvtielk ngttvwgtlq svspqmnail tdvkltlpqp rlnklnsngi 61 amaslyltgg qqptasdnia slqyinirgn tirqiilpds lnldsllvdq kqlnslrrsg 121 qiandpskkr rrdfgapank rprrgl // LOCUS NP_011589 242 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit PRP38 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011589 VERSION NP_011589.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181204.3 REFERENCE 1 (residues 1 to 242) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 242) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 242) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 242) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08168. On Jul 30, 2012 this sequence version replaced NP_011589.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..242 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..242 /product="U4/U6-U5 snRNP complex subunit PRP38" /calculated_mol_wt="27836" Region 15..211 /region_name="PRP38" /note="PRP38 family; pfam03371" /db_xref="CDD:460901" CDS 1..242 /gene="PRP38" /locus_tag="YGR075C" /coded_by="NM_001181204.3:1..729" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:mutant phenotype:GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [PMID:9582287]" /experiment="EXISTENCE:mutant phenotype:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:9582287]" /note="Unique component of the U4/U6.U5 tri-snRNP particle; tri-snRNP is required for conformational changes which result in the catalytic activation of the spliceosome; dispensable for spliceosome assembly" /db_xref="GeneID:852966" /db_xref="SGD:S000003307" ORIGIN 1 mavnefqves nispkqlnnq svslviprlt rdkihnsmyy kvnlsneslr gntmvellkv 61 migafgtikg qnghlhmmvl ggiefkcilm klieirpnfq qlnfllnvkn engfdskyii 121 alllvyarlq yyylngnnkn dddendlikl fkvqlykysq hyfklksfpl qvdcfahsyn 181 eelciihide lvdwlatqdh iwgiplgkcq wnkiynsdee ssssesesng dseddndtss 241 es // LOCUS NP_011590 157 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL59 MRPL25 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011590 VERSION NP_011590.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181205.1 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08169. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..157 /product="mitochondrial 54S ribosomal protein mL59 MRPL25" /calculated_mol_wt="18456" Region 13..138 /region_name="Mitoc_mL59" /note="Mitochondrial ribosomal protein mL59; pfam18126" /db_xref="CDD:436292" CDS 1..157 /gene="MRPL25" /locus_tag="YGR076C" /gene_synonym="AFO1; mL59; YMR26" /coded_by="NM_001181205.1:1..474" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan" /db_xref="GeneID:852967" /db_xref="SGD:S000003308" ORIGIN 1 msykqyfdsl plklksffqr yppsikyspv ststkainan pflpnkhpvt qrfhdpkysl 61 rrmsdvykla lrygveeflp pientkklff eekynkktlm kgvllpkghk helklneklk 121 kreealkkvd eliaskkgsk yakrvekmkk nqsigwf // LOCUS NP_011591 589 aa linear PLN 30-JUN-2025 DEFINITION Pex8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011591 VERSION NP_011591.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181206.1 REFERENCE 1 (residues 1 to 589) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 589) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 589) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 589) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08170. Method: conceptual translation. FEATURES Location/Qualifiers source 1..589 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..589 /product="Pex8p" /calculated_mol_wt="68034" CDS 1..589 /gene="PEX8" /locus_tag="YGR077C" /gene_synonym="PAS6" /coded_by="NM_001181206.1:1..1770" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:12667447]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:22375831]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:10652355]" /note="Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p" /db_xref="GeneID:852968" /db_xref="SGD:S000003309" ORIGIN 1 mfdhdveyli talssetriq ydqrlldeia anvvyyvprv kspdtlyrlv galfrsqfiv 61 qlpplrllhi vkdvflwkle vseptlpisk fylvwnavfe shratwnlsq lmvldgvlvt 121 ypsfkqlnna yfidessnkt alyyrnwklq lfspiwaqlw ntaivranls iqhclliala 181 llfnqsnrsa llhgvdvswn lvteklldll eeyvhgivqp meifstdsvl stnlnhlasc 241 ltssitrsne atlvnsvrkl ericrylsdt vaslkeqqld fkfqnvfili ilalkelsam 301 nmtilpnhkd tfysmiclsl fhvhvltqki gtvgfpsydy vydnlvtyfi vmddlskitt 361 vlelmkrnnt kqdpnklvfy inflnkitny ygcrirlpfi tefiepllhf dvffsgktgn 421 tldieikesi htltitvlsi dssyssqvaq wqvsrilvyl kmsmdqfiag klsanqilli 481 fghlstqlps lhnynkhllr dslhetyiri vnvknpekkn vlieclivqi afinnphhli 541 gwlniclqli nthnkkllqq lwemvssles slaidwwytt vlssqsskl // LOCUS NP_011592 199 aa linear PLN 30-JUN-2025 DEFINITION tubulin-binding prefolding complex subunit PAC10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011592 VERSION NP_011592.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181207.3 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08171. On Jul 30, 2012 this sequence version replaced NP_011592.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..199 /product="tubulin-binding prefolding complex subunit PAC10" /calculated_mol_wt="22984" Region 40..177 /region_name="Prefoldin_3" /note="Prefoldin subunit 3; cd23156" /db_xref="CDD:467472" Region 40..79 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467472" Site order(41,44..45,48,161,164..165,167..169,171..172) /site_type="other" /note="prefoldin/TRiC interface [polypeptide binding]" /db_xref="CDD:467472" Site order(68,71..72,75..76,78..79,93..100,102..111,119..123, 127..132,141) /site_type="other" /note="prefoldin oligomer interface [polypeptide binding]" /db_xref="CDD:467472" Region 135..177 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467472" CDS 1..199 /gene="PAC10" /locus_tag="YGR078C" /gene_synonym="GIM2; PFD3; RKS2" /coded_by="NM_001181207.3:1..600" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9463374]" /experiment="EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:9463374]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9611197]" /experiment="EXISTENCE:physical interaction:GO:0016272 prefoldin complex [PMID:9463374]" /note="Part of the heteromeric co-chaperone GimC/prefoldin complex; complex promotes efficient protein folding" /db_xref="GeneID:852969" /db_xref="SGD:S000003310" ORIGIN 1 mdtlfnstek nargipqapf ienvneiikd psdfelcfnk fqerlskykf mqesklatik 61 qlktripdle ntlkicqslr nhsdegdesd epillhyqln dtlytkaqvd ipedradlkv 121 glwlgadvml eypideaiel lkkkladseq sltvstedve flrenittme vncarlynwd 181 vqrrqdlkqa qegtknlki // LOCUS NP_011593 370 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR079W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011593 VERSION NP_011593.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181208.1 REFERENCE 1 (residues 1 to 370) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 370) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 370) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 370) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08172. Method: conceptual translation. FEATURES Location/Qualifiers source 1..370 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..370 /product="uncharacterized protein" /calculated_mol_wt="40746" CDS 1..370 /locus_tag="YGR079W" /coded_by="NM_001181208.1:1..1113" /note="hypothetical protein; YGR079W is not an essential gene" /db_xref="GeneID:852970" /db_xref="SGD:S000003311" ORIGIN 1 mssaanegcv ylfivvlrls sfscvnsfih sftrsrtrss yslderslvs ysivyvamnk 61 sskafqvpnk vitkeditpl srshtkkadt rgtadgkntt asaveatpii ittarsidta 121 gslsenated dgtqngdlhd ddddddlest lgyssepdpl fspchqpsft nstfsysadn 181 elpmeenhnk nnfhdssess iflpqiqqsf ffgdnsksda nntdfwkevn gtaeeaiclq 241 etrqrkcslv alhpgdatts sndtlgiedf ikddinsaea mepspsssps sslldnldyn 301 ikllcyrdne gkftlkkrkf lknslrsssa iskkwkplsk rdkllkrair rksgvcqtls 361 agfgigefml // LOCUS NP_011594 332 aa linear PLN 30-JUN-2025 DEFINITION twinfilin TWF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011594 VERSION NP_011594.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181209.3 REFERENCE 1 (residues 1 to 332) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 332) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 332) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 332) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08173. On Jul 30, 2012 this sequence version replaced NP_011594.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..332 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..332 /product="twinfilin TWF1" /calculated_mol_wt="36940" Region 4..124 /region_name="ADF_Twf-N_like" /note="N-terminal ADF domain of twinfilin and related proteins; cd11285" /db_xref="CDD:200441" Site 5..6 /site_type="other" /note="putative G-actin interface [polypeptide binding]" /db_xref="CDD:200441" Region 175..297 /region_name="ADF_Twf-C_like" /note="C-terminal ADF domain of twinfilin and related proteins; cd11284" /db_xref="CDD:200440" Site order(175..178,207,245,247,250,253..254,256..258,260..261, 263,281,283,285) /site_type="other" /note="G-actin binding interface [polypeptide binding]" /db_xref="CDD:200440" Site order(254,286,289) /site_type="other" /note="putative F-actin interface [polypeptide binding]" /db_xref="CDD:200440" CDS 1..332 /gene="TWF1" /locus_tag="YGR080W" /coded_by="NM_001181209.3:1..999" /experiment="EXISTENCE:direct assay:GO:0003785 actin monomer binding [PMID:9700161]" /experiment="EXISTENCE:direct assay:GO:0005884 actin filament [PMID:26458246]" /experiment="EXISTENCE:direct assay:GO:0007015 actin filament organization [PMID:16569665]" /experiment="EXISTENCE:direct assay:GO:0030042 actin filament depolymerization [PMID:16569665|PMID:26458246]" /experiment="EXISTENCE:direct assay:GO:0030836 positive regulation of actin filament depolymerization [PMID:26458246]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051014 actin filament severing [PMID:16569665]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:16569665]" /experiment="EXISTENCE:direct assay:GO:0140311 protein sequestering activity [PMID:9700161]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:16569665]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:16569665]" /experiment="EXISTENCE:mutant phenotype:GO:0051014 actin filament severing [PMID:16569665]" /note="Twinfilin; highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton; coordinates actin filament severing and monomer sequestering at sites of rapid actin turnover; composed of two cofilin-like regions, stimulates actin depolymerization as does the mouse homolog, mTwf1" /db_xref="GeneID:852971" /db_xref="SGD:S000003312" ORIGIN 1 mstqsgivae qallhslnen lsadgiviii akispdstsv hqtqvarsfe elvqlasqer 61 eplyifykpe gldkyffvsf ipdgspvrsr mlyastkntl arqvgsnsls teqplitdaq 121 dlvdlknfds arpagqnkpl thdeemqiei nkqqallrkn tsvklvsqds asplsltfrv 181 nsekpineil dsegknliif qidpsnetiq ivqsdtcpsv delyidlpgp sytifrqgds 241 sffiyscpsg skvkdrmiya snkngfinyl kndqkiafsk vveigdfvel dksllmatnk 301 edsldhgsnp dlpnksnlkf nkpkgplrkr rt // LOCUS NP_011595 210 aa linear PLN 30-JUN-2025 DEFINITION Slx9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011595 VERSION NP_011595.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181210.3 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08174. On Jul 30, 2012 this sequence version replaced NP_011595.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..210 /product="Slx9p" /calculated_mol_wt="23938" Region 47..206 /region_name="SLX9" /note="Ribosome biogenesis protein SLX9; pfam15341" /db_xref="CDD:464660" CDS 1..210 /gene="SLX9" /locus_tag="YGR081C" /coded_by="NM_001181210.3:1..633" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:17018574]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:17018574]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:31067825]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17018574]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:22956913]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17018574]" /note="Nuclear export receptor for exportin Crm1p; required for pre-rRNA processing and nuclear export of pre-40S pre-ribosomal particles; associates with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; binds G-quadruplex (G4) structures in DNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant" /db_xref="GeneID:852972" /db_xref="SGD:S000003313" ORIGIN 1 mvakkrntlr skvsarnsqn fgpdvanngi ldesydiesd praflhqpke tkkekllnrq 61 ntflsnlkgk stlndgiaan fdgiskssir rrkrklreel kprmqdllts leqekdlrgi 121 iensskdmnn dddidmdski rfvdtkemnl kkiepgsvri kknqpnirnq kgakalaane 181 tarfnqvltn qdfqknpfga lreviklqkq // LOCUS NP_011596 183 aa linear PLN 30-JUN-2025 DEFINITION TOM complex receptor protein TOM20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011596 VERSION NP_011596.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181211.1 REFERENCE 1 (residues 1 to 183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 183) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08175. Method: conceptual translation. FEATURES Location/Qualifiers source 1..183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..183 /product="TOM complex receptor protein TOM20" /calculated_mol_wt="20186" Region 1..154 /region_name="3a0801s04tom" /note="mitochondrial import receptor subunit translocase of outer membrane 20 kDa subunit; TIGR00985" /db_xref="CDD:273378" CDS 1..183 /gene="TOM20" /locus_tag="YGR082W" /gene_synonym="MAS20; MOM19" /coded_by="NM_001181211.1:1..552" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:16689936]" /experiment="EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]" /experiment="EXISTENCE:direct assay:GO:0030943 mitochondrion targeting sequence binding [PMID:9252394]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:8132642]" /experiment="EXISTENCE:mutant phenotype:GO:0016031 tRNA import into mitochondrion [PMID:7837265]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:8132642|PMID:9774667|PMID:8223428]" /note="Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins" /db_xref="GeneID:852973" /db_xref="SGD:S000003314" ORIGIN 1 msqsnpilrg laittaiaal satgyaiyfd yqrrnspqfr kvlrqrakeq akmeeqakth 61 akevklqkvt eflsmelakd pipsdpsere atfttnveng erlsmqqgke leaaskfyka 121 ltvypqpadl lgiyqrsipe aiyeyiilmi ailppanvas fvkgvvgska esdavaeand 181 idd // LOCUS NP_011597 651 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF2B subunit delta [Saccharomyces cerevisiae S288C]. ACCESSION NP_011597 VERSION NP_011597.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181212.1 REFERENCE 1 (residues 1 to 651) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 651) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 651) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 651) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08176. Method: conceptual translation. FEATURES Location/Qualifiers source 1..651 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..651 /product="translation initiation factor eIF2B subunit delta" /calculated_mol_wt="70721" Region 105..>246 /region_name="DUF5585" /note="Family of unknown function (DUF5585); pfam17823" /db_xref="CDD:465521" Region 285..637 /region_name="IF-2B" /note="Initiation factor 2 subunit family; pfam01008" /db_xref="CDD:395798" CDS 1..651 /gene="GCD2" /locus_tag="YGR083C" /gene_synonym="GCD12" /coded_by="NM_001181212.1:1..1956" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:8887689]" /experiment="EXISTENCE:direct assay:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:8506384]" /experiment="EXISTENCE:genetic interaction:GO:0003743 translation initiation factor activity [PMID:8336705]" /experiment="EXISTENCE:genetic interaction:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8336705]" /experiment="EXISTENCE:genetic interaction:GO:0006446 regulation of translational initiation [PMID:8887689|PMID:8164676]" /experiment="EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:8164676|PMID:8887689]" /experiment="EXISTENCE:genetic interaction:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:8336705]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:2038326]" /experiment="EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:9032257]" /experiment="EXISTENCE:mutant phenotype:GO:0030234 enzyme regulator activity [PMID:9032257]" /experiment="EXISTENCE:physical interaction:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8506384]" /experiment="EXISTENCE:physical interaction:GO:0006446 regulation of translational initiation [PMID:8887689]" /note="Delta subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression" /db_xref="GeneID:852974" /db_xref="SGD:S000003315" ORIGIN 1 mseseaksrs atppskakqa tptttaaang ekkltnkelk elkkqekaak raamkqangi 61 sieqqqqqaq mkkekkqlqr eqqqkreqkq knankkkqne rnvkkstlfg hletteerra 121 tilaltsavs spktsritaa glmvpvvasa lsgsnvltas slmpvgpnas stvsasapas 181 ttttlpassa alsagtssas tntptaiqqe iassnasdva ktlasislea gefnvipgis 241 sviptvleqs fdnsslissv kelllnkdli hpsillltsh lahykivgsi prciamlevf 301 qivikdyqtp kgttlsrnlt sylshqidll kkarplsvtm gnairwlkqe islidpstpd 361 kaakkdlcek igqfakekie ladqliidna stqieestti vtygsskvlt elllhnaisl 421 kknikvivvd srplfegrkm aetlrnagvn vmyalitsld tifnmdvdyv flgahsilsn 481 gflysragta mlamsakrrn ipvlvccesl kfsqrvqlds vtfneladpn dlvnidyenp 541 verrgnkgal lnqfikerkf ekkklamenk pkgnkiggkk gsegeskdas needsnskni 601 ldgwqelpsl nivnilydlt ppeyikkvit efgalppssv pvilreykgs a // LOCUS NP_011598 339 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS44 MRP13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011598 VERSION NP_011598.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181213.3 REFERENCE 1 (residues 1 to 339) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 339) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 339) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 339) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08177. On Jul 30, 2012 this sequence version replaced NP_011598.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..339 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..339 /product="mitochondrial 37S ribosomal protein mS44 MRP13" /calculated_mol_wt="38857" Region 43..318 /region_name="mS44" /note="Saccharomyces cerevisiae mitochondrial small ribosomal subunit protein mS44, and similar proteins; cd23704" /db_xref="CDD:467917" CDS 1..339 /gene="MRP13" /locus_tag="YGR084C" /gene_synonym="mS44" /coded_by="NM_001181213.3:1..1020" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552|PMID:9151978]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:852975" /db_xref="SGD:S000003316" ORIGIN 1 mgtitvvine gpilliralh rattnkkmfr stvwrrfast geiakaklde fliyhktdak 61 lkpfiyrpkn aqilltkdir dpktreplqp rppvkplskq tlndfiysve pnstelldwf 121 kewtgtsirk raiwtyispi hvqkmltasf fkigkyahmv gllygiehkf lkaqnpsvfd 181 iehffntnim calhrnrlkd ykdaeiaqrk lqvawkkvln rknntglani lvatlgrqig 241 ftpeltglqp vdislpdipn sssgaelkdl lskyegiyli artlldidqh naqylelqef 301 irqyqnalse ssdpydthlk alglletppp qestekeek // LOCUS NP_011599 174 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL5 RPL11B [Saccharomyces cerevisiae S288C]. ACCESSION NP_011599 VERSION NP_011599.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181214.1 REFERENCE 1 (residues 1 to 174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 174) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08178. Method: conceptual translation. FEATURES Location/Qualifiers source 1..174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..174 /product="60S ribosomal protein uL5 RPL11B" /calculated_mol_wt="19619" Region 2..172 /region_name="PTZ00156" /note="60S ribosomal protein L11; Provisional" /db_xref="CDD:185485" CDS 1..174 /gene="RPL11B" /locus_tag="YGR085C" /coded_by="NM_001181214.1:1..525" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:2277060]" /note="Ribosomal 60S subunit protein L11B; expressed at half the level of Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11B has a paralog, RPL11A, that arose from the whole genome duplication" /db_xref="GeneID:852976" /db_xref="SGD:S000003317" ORIGIN 1 mstkaqnpmr dlkieklvln isvgesgdrl traskvleql sgqtpvqska rytvrtfgir 61 rnekiavhvt vrgpkaeeil erglkvkeyq lrdrnfsatg nfgfgidehi dlgikydpsi 121 gifgmdfyvv mnrpgarvtr rkrckgtvgn shkttkedtv swfkqkydad vldk // LOCUS NP_011600 339 aa linear PLN 30-JUN-2025 DEFINITION lipid-binding protein PIL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011600 VERSION NP_011600.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181215.3 REFERENCE 1 (residues 1 to 339) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 339) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 339) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 339) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08179. On Jul 30, 2012 this sequence version replaced NP_011600.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..339 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..339 /product="lipid-binding protein PIL1" /calculated_mol_wt="38218" Region 1..264 /region_name="Pil1" /note="Eisosome component PIL1; pfam13805" /db_xref="CDD:404658" CDS 1..339 /gene="PIL1" /locus_tag="YGR086C" /coded_by="NM_001181215.3:1..1020" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:36162502|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:22123866]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:22869600|PMID:16496001]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:16496001]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:16496001]" /experiment="EXISTENCE:mutant phenotype:GO:0070941 eisosome assembly [PMID:19037108|PMID:18296441]" /experiment="EXISTENCE:mutant phenotype:GO:0097446 protein localization to eisosome filament [PMID:25811606]" /note="Eisosome core component involved in endocytosis; mitochondria phosphoprotein that localizes to the outer membrane and is involved in maintaining mitochondrial morphology and mitophagy; phosphorylated (T233) upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; BAR domain family member; protein increases in abundance and relocalizes from the plasma membrane to cytoplasm upon DNA replication stress" /db_xref="GeneID:852977" /db_xref="SGD:S000003318" ORIGIN 1 mhrtyslrns raptasqlqn pppppsttkg rffgkgglay sfrrsaagaf gpelsrklsq 61 lvkieknvlr smeltanerr daakqlsiwg lendddvsdi tdklgvliye vselddqfid 121 rydqyrltlk sirdiegsvq psrdrkdkit dkiaylkykd pqspkievle qelvraeaes 181 lvaeaqlsni trsklraafn yqfdsiiehs ekialiagyg kallelldds pvtpgetrpa 241 ydgyeaskqi iidaesalne wtldsaqvkp tlsfkqdyed fepeegeeee eedgqgrwse 301 deqedgqiee peqeeegave eheqvghqqs eslpqqtta // LOCUS NP_011601 563 aa linear PLN 30-JUN-2025 DEFINITION indolepyruvate decarboxylase 6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011601 VERSION NP_011601.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181216.3 REFERENCE 1 (residues 1 to 563) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 563) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 563) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 563) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08180. On Jul 30, 2012 this sequence version replaced NP_011601.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..563 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..563 /product="indolepyruvate decarboxylase 6" /EC_number="4.1.1.43" /EC_number="4.1.1.72" /EC_number="4.1.1.74" /calculated_mol_wt="61449" Region 1..551 /region_name="PDC1" /note="TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]; COG3961" /db_xref="CDD:443161" CDS 1..563 /gene="PDC6" /locus_tag="YGR087C" /coded_by="NM_001181216.3:1..1692" /experiment="EXISTENCE:direct assay:GO:0004737 pyruvate decarboxylase activity [PMID:23423327]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0006559 L-phenylalanine catabolic process [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0006569 L-tryptophan catabolic process [PMID:12499363]" /experiment="EXISTENCE:mutant phenotype:GO:0004737 pyruvate decarboxylase activity [PMID:1744053]" /experiment="EXISTENCE:mutant phenotype:GO:0006067 ethanol metabolic process [PMID:1744053]" /note="Minor isoform of pyruvate decarboxylase; decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation" /db_xref="GeneID:852978" /db_xref="SGD:S000003319" ORIGIN 1 mseitlgkyl ferlkqvnvn tifglpgdfn lslldkiyev dglrwagnan elnaayaadg 61 yarikglsvl vttfgvgels alngiagsya ehvgvlhvvg vpsisaqakq lllhhtlgng 121 dftvfhrmsa nisettsmit diatapseid rlirttfitq rpsylglpan lvdlkvpgsl 181 lekpidlslk pndpeaekev idtvleliqn sknpvilsda casrhnvkke tqklidltqf 241 pafvtplgkg sideqhpryg gvyvgtlskq dvkqavesad lilsvgalls dfntgsfsys 301 yktknvvefh sdyvkvknat flgvqmkfal qnllkvipdv vkgyksvpvp tktpankgvp 361 astplkqewl wnelskflqe gdviisetgt safginqtif pkdaygisqv lwgsigfttg 421 atlgaafaae eidpnkrvil figdgslqlt vqeistmirw glkpylfvln ndgytiekli 481 hgphaeynei qtwdhlallp afgakkyenh kiattgewda lttdsefqkn svirlielkl 541 pvfdapesli kqaqltaatn akq // LOCUS NP_011602 562 aa linear PLN 30-JUN-2025 DEFINITION catalase T [Saccharomyces cerevisiae S288C]. ACCESSION NP_011602 VERSION NP_011602.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181217.1 REFERENCE 1 (residues 1 to 562) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 562) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 562) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 562) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08181. On Feb 6, 2006 this sequence version replaced NP_011602.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..562 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..562 /product="catalase T" /EC_number="1.11.1.6" /calculated_mol_wt="64452" Region 41..541 /region_name="catalase_fungal" /note="Fungal catalases similar to yeast catalases A and T; cd08157" /db_xref="CDD:163713" Site order(57,62,110..111,130..131,146..150,152,155,161..166, 173,176,240,243,246..247,251,254..255,258,281..282,287,289, 315,317..318,320,323,330..331,340,342,345,348..350, 353..354,357..359,361..362,364..367,371,394..395,397,400, 402..404,413..418,510..511,514,516,520) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:163713" Site order(64,103,137,142,150,347,351) /site_type="other" /note="heme binding pocket [chemical binding]" /db_xref="CDD:163713" Site order(140,186,190,193,195,205,227,229,294..297,484, 487..488) /site_type="other" /note="NADPH binding site [chemical binding]" /db_xref="CDD:163713" CDS 1..562 /gene="CTT1" /locus_tag="YGR088W" /gene_synonym="SPS101" /coded_by="NM_001181217.1:1..1689" /experiment="EXISTENCE:direct assay:GO:0004096 catalase activity [PMID:19463791]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000302 response to reactive oxygen species [PMID:15893481]" /note="Cytosolic catalase T; has a role in protection from oxidative damage by hydrogen peroxide" /db_xref="GeneID:852979" /db_xref="SGD:S000003320" ORIGIN 1 mnvfgkkeek qekvyslqng fpyshhpyas qysrpdgpil lqdfhlleni asfdrervpe 61 rvvhakgggc rlefeltdsl sdityaapyq nvgykcpglv rfstvggesg tpdtardprg 121 vsfkfytewg nhdwvfnntp vfflrdaikf pvfihsqkrd pqshlnqfqd ttiywdyltl 181 npesihqity mfgdrgtpas wasmnaysgh sfimvnkegk dtyvqfhvls dtgfetltgd 241 kaaelsgshp dynqaklftq lqngekpkfn cyvqtmtpeq atkfrysvnd ltkiwphkef 301 plrkfgtitl tenvdnyfqe ieqvafsptn tcipgikpsn dsvlqarlfs ypdtqrhrlg 361 anyqqlpvnr prnlgcpysk gdsqytaeqc pfkavnfqrd gpmsyynfgp epnyisslpn 421 qtlkfknedn devsdkfkgi vldevtevsv rkqeqdqirn ehivdakinq yyyvygispl 481 dfeqpralye kvyndeqkkl fvhnvvchac kikdpkvkkr vtqyfgllne dlgkviaecl 541 gvpwepvdle gyaktwsias an // LOCUS NP_011603 936 aa linear PLN 30-JUN-2025 DEFINITION Nnf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011603 VERSION NP_011603.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181218.1 REFERENCE 1 (residues 1 to 936) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 936) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 936) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 936) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 936) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 936) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 936) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 936) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08182. Method: conceptual translation. FEATURES Location/Qualifiers source 1..936 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..936 /product="Nnf2p" /calculated_mol_wt="106335" Region 819..>928 /region_name="COG4372" /note="Uncharacterized protein, contains DUF3084 domain [Function unknown]" /db_xref="CDD:443500" CDS 1..936 /gene="NNF2" /locus_tag="YGR089W" /coded_by="NM_001181218.1:1..2811" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Protein that exhibits physical and genetic interactions with Rpb8p; Rpb8p is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation" /db_xref="GeneID:852980" /db_xref="SGD:S000003321" ORIGIN 1 meeqftnqkk vshlqslmnt krseqptefa kkhrfkdtla lflvflsfnh ftslcllvsf 61 ivatkckdfl ancfiilfls kkpsrhigev ahidistskv tngssnrksn srffgnskns 121 fvipipvlic eilfamllki yggdyfvkpi knlaisiias flindpsdcl syatscsvly 181 avstntfqrv shffdiiqlf dmslrgtgqs iklftvfrky sqffkklfsl flpmpfkmlg 241 khsdsmiyyl sfhilffsfa ssllhphrqt aenkplkkgf nstkpdvarv qglqkmriss 301 sssvsadsnt ledqspmipn dpgglsssnq tihpsqqnns pvplsshsni lnpaasyptd 361 atssfpyfts mvkeyksyqp svisaegsns qavttttstt tspttfnfsg dntslsneis 421 lsdssngnsk kdsdffspsn dkytnqlfel nvdfgnmfss sklssdisvt snlenfirll 481 frrknqhlia plwsmvvtlk ttnfekkylq etsensltpt nsntsyvsnq ekhdkdldti 541 nthsvssris fthagkfkks vfnnfepsnt maliakttsd dynllnlvst nenifnrndn 601 dykvciidis tnsitfhien lhdgelivlv ngviwsevsc alilehvgee yvvvnglvps 661 csydiqfinr lnhrddylvs dlivrtcgnn naiagkfenl dfsfpsyyhr kflsplltlk 721 hsvlttnanl sdertklkkt kkefskklsl lrqeidyfkg risqnathde kstlkvenlk 781 valqqsetav nklemqlktl tekeleleee ylkkkdlhlk nqlefsklee slskdlknse 841 grfqkvnqel vqlgskldkl narneklqke vdqnaeeiek fstqflskre kdrfrrkeyr 901 ireankfelt ikgleqdinr lenenenihs lignsy // LOCUS NP_011604 1237 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein UTP22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011604 VERSION NP_011604.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181219.3 REFERENCE 1 (residues 1 to 1237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1237) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08183. On Jul 30, 2012 this sequence version replaced NP_011604.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1237 /product="rRNA-processing protein UTP22" /calculated_mol_wt="140354" Region 203..355 /region_name="Nrap" /note="Nrap protein domain 1; pfam03813" /db_xref="CDD:461061" Region 358..514 /region_name="Nrap_D2" /note="Nrap protein PAP/OAS-like domain; pfam17403" /db_xref="CDD:465416" Region 519..691 /region_name="Nrap_D3" /note="Nrap protein domain 3; pfam17404" /db_xref="CDD:465417" Region 704..904 /region_name="Nrap_D4" /note="Nrap protein nucleotidyltransferase domain 4; pfam17405" /db_xref="CDD:465418" Region 906..1091 /region_name="Nrap_D5" /note="Nrap protein PAP/OAS1-like domain 5; pfam17406" /db_xref="CDD:465419" Region 1093..1231 /region_name="Nrap_D6" /note="Nrap protein domain 6; pfam17407" /db_xref="CDD:465420" CDS 1..1237 /gene="UTP22" /locus_tag="YGR090W" /coded_by="NM_001181219.3:1..3714" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15590835|PMID:12150911|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0032545 CURI complex [PMID:17452446]" /experiment="EXISTENCE:direct assay:GO:0034456 UTP-C complex [PMID:17515605]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12837249]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:23194188]" /note="Component of the small-subunit processome; required for nuclear export of tRNAs; forms a complex with Rrp7p; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals" /db_xref="GeneID:852982" /db_xref="SGD:S000003322" ORIGIN 1 matsvkrkas etsdqnivkv qkkhstqdst tdngskendh ssqainertv peqendesdt 61 spesnevatn taatrhngkv tatesydihi aretaelfks nifklqidel leqvklkqkh 121 vlkvekflhk lydilqeipd weekslaevd sffknkivsv pfvdpkpipq ntnykfnykk 181 pdisligsfa lkagiyqpng ssidtlltmp kelfekkdfl nfrclhkrsv ylaylthhll 241 illkkdklds flqleysyfd ndpllpilri scskptgdsl sdynfyktrf sinlligfpy 301 kvfepkkllp nrnciriaqe skeqslpatp lynfsvlsss thenylkyly ktkkqtesfv 361 eatvlgrlwl qqrgfssnms hsgslggfgt feftilmaal lnggginsnk illhgfssyq 421 lfkgvikyla tmdlchdghl qfhsnpenss sspaskyide gfqtptlfdk stkvniltkm 481 tvssyqilke yagetlrmln nvvqdqfsni fltnisrfdn lkydlcydvq lplgkynnle 541 tslaatfgsm ervkfitlen flahkitnva ryalgdriky iqiemvgqks dfpitkrkvy 601 sntggnhfnf dfvrvklivn psecdklvtk gpahsetmst eaavfknfwg iksslrrfkd 661 gsithccvws tsssepiiss ivnfalqkhv skkaqisnet ikkfhnflpl pnlpssakts 721 vlnlssffnl kksfddlyki ifqmklplsv ksilpvgsaf rytslcqpvp faysdpdffq 781 dvilefetsp kwpdeitsle kaktafllki qeelsansst yrsffsrdes ipynleivtl 841 niltpegygf kfrvlterde ilylraiana rnelkpelea tflkftakyl asvrhtrtle 901 nishsyqfys pvvrlfkrwl dthlllghit delaeliaik pfvdpapyfi pgslengflk 961 vlkfisqwnw kddplildlv kpeddirdtf etsigagsel dsktmkklse rltlaqykgi 1021 qmnftnlrns dpngthlqff vaskndpsgi lyssgiplpi atrltalakv avnllqthgl 1081 nqqtinllft pglkdydfvv dlrtpiglks scgilsatef knitndqaps nfpenlndls 1141 ekmdptyqlv kylnlkykns lilssrkyig vnggekgdkn vitglikplf kgahkfrvnl 1201 dcnvkpvdde nvilnkeaif heiaafgndm vinfetd // LOCUS NP_011605 494 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit PRP31 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011605 VERSION NP_011605.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181220.1 REFERENCE 1 (residues 1 to 494) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 494) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 494) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 494) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08184. Method: conceptual translation. FEATURES Location/Qualifiers source 1..494 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..494 /product="U4/U6-U5 snRNP complex subunit PRP31" /calculated_mol_wt="56172" Region 105..343 /region_name="Nop" /note="snoRNA binding domain, fibrillarin; pfam01798" /db_xref="CDD:460335" Region 350..450 /region_name="Prp31_C" /note="Prp31 C terminal domain; pfam09785" /db_xref="CDD:462898" CDS 1..494 /gene="PRP31" /locus_tag="YGR091W" /coded_by="NM_001181220.1:1..1485" /experiment="EXISTENCE:direct assay:GO:0000387 spliceosomal snRNP assembly [PMID:9199293]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:mutant phenotype:GO:0000387 spliceosomal snRNP assembly [PMID:9199293]" /note="Splicing factor; component of the U4/U6-U5 snRNP complex; homologous to human PRPF31 and used to study retinitis pigmentosa" /db_xref="GeneID:852983" /db_xref="SGD:S000003323" ORIGIN 1 msseedyfde leydladevn eekediqtkk lttvncqtek fnpfeilpes ielfrtlali 61 spdrlslset aqilpkivdl krilqqqeid fikllpffne iipliksnik lmhnflisly 121 srrfpelssl ipsplqyskv isilenenys knesdelffh lenkakltre qilvltmsmk 181 tsfknkepld iktrtqilea nsilenlwkl qedigqyias kisiiapnvc flvgpeiaaq 241 liahaggvle fsripscnia sigknkhlsh elhtlesgvr qegylfasdm iqkfpvsvhk 301 qmlrmlcakv slaarvdagq kngdrntvla hkwkaelskk arklseapsi setkalpipe 361 dqpkkkragr kfrkykekfr lshvrqlqnr mefgkqeqtv ldsygeevgl gmsntslqqa 421 vgatsgsrrs agnqakltkv mkhriseanq qadeflislg hnteqpnlsp emvqmhkkqh 481 tnpeeetnwf sghg // LOCUS NP_011606 572 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine-protein kinase DBF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011606 VERSION NP_011606.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181221.3 REFERENCE 1 (residues 1 to 572) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 572) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 572) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 572) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08185. On Jul 30, 2012 this sequence version replaced NP_011606.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..572 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..572 /product="serine/threonine-protein kinase DBF2" /EC_number="2.7.11.1" /calculated_mol_wt="66017" Region 85..172 /region_name="MobB_Sid2p-like" /note="Mob-binding domain found in fungal Sid2p-like serine/threonine protein kinases; cd21776" /db_xref="CDD:439271" Site order(107..108,110..112,114..115,118..119,122,125,129,158, 161..163,165..166,169..170) /site_type="other" /note="putative Mob binding site [polypeptide binding]" /db_xref="CDD:439271" Region 165..547 /region_name="STKc_Sid2p_like" /note="Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; cd05600" /db_xref="CDD:270751" Site order(183..187,191,204,206,238,254..255,257,261,263,300, 302,304..305,307,317..318,321,375..380,407,413,416) /site_type="active" /db_xref="CDD:270751" Site order(183..187,191,204,206,238,255..257,261,300,302, 304..305,307,317..318) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270751" Site order(187,261,263,300,302,304,321,375..380,407,413,416) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270751" Site order(317..327,371..380) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270751" Site 540..545 /site_type="other" /note="hydrophobic motif (HM)" /db_xref="CDD:270751" CDS 1..572 /gene="DBF2" /locus_tag="YGR092W" /coded_by="NM_001181221.3:1..1719" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8131744|PMID:21498574]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10984431|PMID:11434459]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10984431|PMID:11434459]" /experiment="EXISTENCE:direct assay:GO:0034973 Sid2-Mob1 complex [PMID:9528782]" /experiment="EXISTENCE:mutant phenotype:GO:0000280 nuclear division [PMID:2181271]" /experiment="EXISTENCE:mutant phenotype:GO:0000910 cytokinesis [PMID:22573892]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:22573892]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:18048916]" /experiment="EXISTENCE:mutant phenotype:GO:0032465 regulation of cytokinesis [PMID:22573892]" /experiment="EXISTENCE:mutant phenotype:GO:1901901 regulation of protein localization to cell division site involved in cytokinesis [PMID:22573892]" /experiment="EXISTENCE:physical interaction:GO:0034973 Sid2-Mob1 complex [PMID:9528782]" /note="Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis; DBF2 has a paralog, DBF20, that arose from the whole genome duplication" /db_xref="GeneID:852984" /db_xref="SGD:S000003324" ORIGIN 1 mlskseknvd llagnmsnls fdghgtpggt glfpnqnitk rrtrpagind spspvkpsff 61 pyedtsnmdi devsqpdmdv snspkklppk fyeratsnkt qrvvsvckmy flehycdmfd 121 yvisrrqrtk qvleylqqqs qlpnsdqikl neewssylqr ehqvlrkrrl kpknrdfemi 181 tqvgqggygq vylarkkdtk evcalkilnk kllfklnetk hvlterdilt ttrsewlvkl 241 lyafqdlqsl ylamefvpgg dfrtllintr clksgharfy isemfcavna lhdlgythrd 301 lkpenflida kghikltdfg laagtisner iesmkirlek ikdlefpaft eksiedrrkm 361 ynqlrekein yansmvgspd ymalevlegk kydftvdyws lgcmlfeslv gytpfsgsst 421 netydnlrrw kqtlrrprqs dgraafsdrt wdlitrliad pinrlrsfeh vkrmsyfadi 481 nfstlrsmip pftpqldset dagyfddfts eadmakyadv fkrqdkltam vddsavsskl 541 vgftfrhrng kqgssgilfn glehsdpfst fy // LOCUS NP_011607 507 aa linear PLN 30-JUN-2025 DEFINITION Drn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011607 VERSION NP_011607.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181222.3 REFERENCE 1 (residues 1 to 507) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 507) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 507) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 507) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08186. On Jul 30, 2012 this sequence version replaced NP_011607.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..507 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..507 /product="Drn1p" /calculated_mol_wt="58075" Region 7..190 /region_name="MPP_superfamily" /note="metallophosphatase superfamily, metallophosphatase domain; cl13995" /db_xref="CDD:472684" Site order(11,13,56,118..119,128,163) /site_type="active" /db_xref="CDD:277317" Site order(11,13,56,118,128,163) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277317" Region 256..381 /region_name="CwfJ_C_1" /note="Protein similar to CwfJ C-terminus 1; pfam04677" /db_xref="CDD:428062" Region 414..502 /region_name="CwfJ_C_2" /note="Protein similar to CwfJ C-terminus 2; pfam04676" /db_xref="CDD:461388" CDS 1..507 /gene="DRN1" /locus_tag="YGR093W" /coded_by="NM_001181222.3:1..1524" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:24919400]" /experiment="EXISTENCE:direct assay:GO:0061632 RNA lariat debranching enzyme activator activity [PMID:24919400]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:24919400]" /note="Splicing factor that modulates turnover of branched RNAs by Dbr1p; interacts with spliceosomal components and branched RNA splicing products; enhances Dbr1p debranching in vitro; conserved protein with domain organization identical from yeast to human; N-terminal homology to Dbr1p N-terminus, but Dbr1p catalytic residues not conserved; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:852985" /db_xref="SGD:S000003325" ORIGIN 1 mtnakilvah isesdadeai rkikkvneks gpfdliiifs nsydenfeln tdglpqlill 61 scdkannsks kkinenvtll hnmgtyklan gitlsyfiyp ddtlqgekks ildefgksed 121 qvdilltkew glsisercgr lsgsevvdel akklqaryhf afsdeinfye lepfqwerer 181 lsrflnipky gsgkkwayaf nmpigdnelk depeppnlia npynsvvtns nkrpletete 241 nsfdgdkqvl anreknenkk irtilpssch fcfsnpnled hmiisigklv ylttakgpls 301 vpkgdmdisg hcliipiehi pkldpsknae ltqsilayea slvkmnyikf dmctivfeiq 361 sersihfhkq vipvpkylvl kfcsaldrqv hfnnekftrn aklefqcyds hsskqyvdvi 421 nnqsnnylqf tvyetpeadp kiylatfnas etidlqfgrr vlafllnlpr rvkwnsstcl 481 qtkqqetiea ekfqkayrty dislten // LOCUS NP_011608 1104 aa linear PLN 30-JUN-2025 DEFINITION valine--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011608 VERSION NP_011608.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181223.1 REFERENCE 1 (residues 1 to 1104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1104) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08187. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1104 /product="valine--tRNA ligase" /EC_number="6.1.1.9" /calculated_mol_wt="125639" Region 128..1104 /region_name="PTZ00419" /note="valyl-tRNA synthetase-like protein; Provisional" /db_xref="CDD:240411" CDS 1..1104 /gene="VAS1" /locus_tag="YGR094W" /coded_by="NM_001181223.1:1..3315" /experiment="EXISTENCE:direct assay:GO:0004832 valine-tRNA ligase activity [PMID:782885]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006438 valyl-tRNA aminoacylation [PMID:782885]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:3275649]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:3275649]" /note="Mitochondrial and cytoplasmic valyl-tRNA synthetase; human homolog VARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant" /db_xref="GeneID:852986" /db_xref="SGD:S000003326" ORIGIN 1 mnkwlntlsk tftfrllnch yrrslplcqn fslkkslthn qvrffkmsdl dnlppvdpkt 61 geviinplke dgspktpkei ekekkkaekl lkfaakqakk naaattgasq kkpkkkkeve 121 pipefidktv pgekkilvsl ddpalkaynp anvesswydw wiktgvfepe ftadgkvkpe 181 gvfcipappp nvtgalhigh altiaiqdsl irynrmkgkt vlflpgfdha giatqsvvek 241 qiwakdrktr hdygreafvg kvwewkeeyh sriknqiqkl gasydwsrea ftlspeltks 301 veeafvrlhd egviyrasrl vnwsvklnta isnlevenkd vksrtllsvp gydekvefgv 361 ltsfaypvig sdekliiatt rpetifgdta vavhpdddry khlhgkfiqh pflprkipii 421 tdkeavdmef gtgavkitpa hdqndyntgk rhnlefinil tddgllneec gpewqgmkrf 481 darkkvieql keknlyvgqe dnemtiptcs rsgdiiepll kpqwwvsqse makdaikvvr 541 dgqititpks seaeyfhwlg niqdwcisrq lwwghrcpvy finiegeehd ridgdywvag 601 rsmeeaekka aakypnskft leqdedvldt wfssglwpfs tlgwpektkd metfypfsml 661 etgwdilffw vtrmillglk ltgsvpfkev fchslvrdaq grkmskslgn vidpldvitg 721 iklddlhakl lqgnldprev ekakigqkes ypngipqcgt damrfalcay ttggrdinld 781 ilrvegyrkf cnkiyqatkf almrlgddyq ppateglsgn eslvekwilh kltetskivn 841 ealdkrdflt stssiyefwy licdvyiens kyliqegsai ekksakdtly illdnalkli 901 hpfmpfisee mwqrlpkrst ekaasivkas ypvyvseydd vksanaydlv lnitkearsl 961 lseynilkng kvfvesnhee yfktaedqkd sivslikaid evtvvrdase ipegcvlqsv 1021 npevnvhllv kghvdidaei akvqkkleka kkskngieqt inskdyetka ntqakeanks 1081 kldntvaeie gleatienlk rlkl // LOCUS NP_011609 223 aa linear PLN 30-JUN-2025 DEFINITION exosome non-catalytic core subunit RRP46 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011609 VERSION NP_011609.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181224.1 REFERENCE 1 (residues 1 to 223) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 223) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 223) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 223) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08188. On Oct 2, 2003 this sequence version replaced NP_011609.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..223 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..223 /product="exosome non-catalytic core subunit RRP46" /calculated_mol_wt="24276" Region 4..210 /region_name="RNase_PH_RRP46" /note="RRP46 subunit of eukaryotic exosome; cd11372" /db_xref="CDD:206777" Site order(8,10..11,13..14,33..35,83,85,124,126..128,130,168, 210) /site_type="other" /note="Rrp40 interface [polypeptide binding]" /db_xref="CDD:206777" Site order(12,14,29,31..33,49,51,56,65,68,72,86,91,96,121..123, 177..188,191,195) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:206777" CDS 1..223 /gene="RRP46" /locus_tag="YGR095C" /coded_by="NM_001181224.1:1..672" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:19046973|PMID:10465791]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:17643380|PMID:15828860]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10508172|PMID:10465791]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:10465791]" /experiment="EXISTENCE:mutant phenotype:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:19369424]" /note="Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)" /db_xref="GeneID:852987" /db_xref="SGD:S000003327" ORIGIN 1 msvqaeigil dhvdgssefv sqdtkvicsv tgpiepkarq elptqlalei ivrpakgvat 61 trekvledkl ravltplitr hcyprqlcqi tcqilesged eaefslrels ccinaaflal 121 vdagialnsm casipiaiik dtsdiivdpt aeqlkislsv htlalefvng gkvvknvlll 181 dsngdfnedq lfsllelgeq kcqelvtnir riiqdnispr lvv // LOCUS NP_011610 314 aa linear PLN 30-JUN-2025 DEFINITION thiamine transporter TPC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011610 VERSION NP_011610.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181225.3 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08189. On Jul 30, 2012 this sequence version replaced NP_011610.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..314 /product="thiamine transporter TPC1" /calculated_mol_wt="35006" Region 16..105 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 21..285 /region_name="PTZ00169" /note="ADP/ATP transporter on adenylate translocase; Provisional" /db_xref="CDD:240302" CDS 1..314 /gene="TPC1" /locus_tag="YGR096W" /coded_by="NM_001181225.3:1..945" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12411483]" /experiment="EXISTENCE:direct assay:GO:0090422 thiamine pyrophosphate transmembrane transporter activity [PMID:12411483]" /experiment="EXISTENCE:direct assay:GO:1990545 mitochondrial thiamine pyrophosphate transmembrane transport [PMID:12411483]" /experiment="EXISTENCE:mutant phenotype:GO:1990545 mitochondrial thiamine pyrophosphate transmembrane transport [PMID:12411483]" /note="Mitochondrial membrane transporter; mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family" /db_xref="GeneID:852988" /db_xref="SGD:S000003328" ORIGIN 1 mfkeedslrk gqnvaawktl lagavsglla rsitapmdti kirlqltpan glkpfgsqvm 61 evarsmikne girsfwkgni pgsllyvtyg saqfssyslf nryltpfgle arlhslvvga 121 fagitssivs ypfdvlrtrl vannqmhsms itrevrdiwk leglpgffkg siasmttitl 181 tasimfgtye tiriycdene kttaahkkwe latlnhsagt iggviakiit fpletirrrm 241 qfmnskhlek fsrhssvygs ykgygfarig lqilkqegvs slyrgilval sktipttfvs 301 fwgyetaihy lrmy // LOCUS NP_011611 1146 aa linear PLN 30-JUN-2025 DEFINITION Ask10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011611 VERSION NP_011611.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181226.1 REFERENCE 1 (residues 1 to 1146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1146) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08190. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1146 /product="Ask10p" /calculated_mol_wt="126733" Region 251..448 /region_name="BAR_4" /note="BAR-like domain; pfam20400" /db_xref="CDD:466549" Region 472..613 /region_name="PH_20" /note="PH domain; pfam20399" /db_xref="CDD:466548" CDS 1..1146 /gene="ASK10" /locus_tag="YGR097W" /gene_synonym="RGC2" /coded_by="NM_001181226.1:1..3441" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19956799|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:14555478]" /experiment="EXISTENCE:mutant phenotype:GO:0016247 channel regulator activity [PMID:24298058]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:14555478]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:14555478]" /experiment="EXISTENCE:mutant phenotype:GO:0090372 positive regulation of glycerol transport [PMID:19956799]" /note="Regulator of the Fps1p glycerol channel; under nonstress conditions, binds to Fps1p to positively regulate glycerol transport; under osmotic stress, multiple phosphorylation by Hog1p causes Ask10p to dissociate from Fps1p; forms homodimers and heterodimerizes with paralog Rgc1p; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; associates with RNA polymerase II holoenzyme" /db_xref="GeneID:852989" /db_xref="SGD:S000003329" ORIGIN 1 msdyfssrps qtltpmgnkp sgggggddas sihskssqyl mdilpdsmtl nesvssivan 61 nqakefilpe tderspyfin vpipkaqpts ttetkkplag deaidgqfvk eyptdilvdr 121 fykwkkilkg lviylrevay aqeqfariny qlkgsvkfpf ltdidettnt itdpfttapr 181 gpkkaqpaqk kvgltdseqf qmqmqqeqqe navqaptdes kmslapheyk pvqttesdnt 241 saasgfvkfg sgsiqdiqvi lkkyhlslan qqfkiskeit stvipkleel rkdlrykite 301 ikdlhgdfkt nigahiqlts qllkkyiaav kfmnahgign drasptnkkp hkldpkhdpy 361 llklqldlql krqvaeetyl qeafinlqss glqlekiiyt kiqhallrys alidsearlm 421 iknmcqelqh giiskppafe wdnfvtqhps cllnwksndp ippprkvsdv iyphmkspla 481 kcikagyflk ksellptyhq gyfvltsnyi hefqssdfyn lssstpnstk ssaysssvsi 541 adtyananna kannhhrqas dvhnsstttg gtagangirg irkksylapi msiplndctl 601 kdasstkfvl vgkptlnena dvrkssssty lsgssqaslp kyghetakif skapfhkflk 661 gskpknkntk sseldqfyaa aqkesnnyvt wtfkivspep seeelkhfkr wvqdlknlts 721 fndtkdrikf iedrvmkshr fkaghmsrns vnigshtpcl tdstftlqdg tttsvnlkgr 781 aekpqyihiq nnsladfdgn gfrskvntpa iddygnlitv errpaqsphq ysdymatsgn 841 ttpsyssgsr pqsmyngynp avsitsngmm lqqstannnt npttnlrhqr nisqtsslpg 901 fsytslslpv nspgssnses ssggyfaipl hgnnnnnnyt qrnsegsspc ynddqirqqq 961 qplqmqplsr tssssvnvta mrstsagnsi tanapvvpkv mvnnqnvktv aadqsataps 1021 sptmnssvtt inrespyqtl kktnstgnvp cltaekthah pafykrgnns aqnlttssst 1081 asrvhpirkh kknvsfssln slmfskkgan hggnlmtnqf msggiqeddg dstnndtikl 1141 nqsiys // LOCUS NP_011612 1630 aa linear PLN 30-JUN-2025 DEFINITION separase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011612 VERSION NP_011612.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181227.3 REFERENCE 1 (residues 1 to 1630) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1630) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1630) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1630) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08191. On Jul 30, 2012 this sequence version replaced NP_011612.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1630 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1630 /product="separase" /EC_number="3.4.22.49" /calculated_mol_wt="187317" Region 1..1630 /region_name="ESP1" /note="Separase, a protease involved in sister chromatid separation [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones]; COG5155" /db_xref="CDD:227484" CDS 1..1630 /gene="ESP1" /locus_tag="YGR098C" /coded_by="NM_001181227.3:1..4893" /experiment="EXISTENCE:direct assay:GO:0004197 cysteine-type endopeptidase activity [PMID:11081625|PMID:11081626]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11149918|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11149918|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:11149918]" /experiment="EXISTENCE:direct assay:GO:0007135 meiosis II [PMID:11081626]" /experiment="EXISTENCE:genetic interaction:GO:0031536 positive regulation of exit from mitosis [PMID:14551257]" /experiment="EXISTENCE:genetic interaction:GO:0032888 regulation of mitotic spindle elongation [PMID:18430955]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:9635435]" /experiment="EXISTENCE:mutant phenotype:GO:0004197 cysteine-type endopeptidase activity [PMID:11081626]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:18321989]" /experiment="EXISTENCE:mutant phenotype:GO:0007135 meiosis II [PMID:11081626]" /experiment="EXISTENCE:mutant phenotype:GO:0031536 positive regulation of exit from mitosis [PMID:14551257|PMID:27418100]" /experiment="EXISTENCE:mutant phenotype:GO:0032888 regulation of mitotic spindle elongation [PMID:18430955]" /experiment="EXISTENCE:mutant phenotype:GO:1904750 negative regulation of protein localization to nucleolus [PMID:14551257]" /note="Separase/separin, a caspase-like cysteine protease; cleaves Mcd1p/Scc1p, a mitotic cohesin complex subunit, resulting in the dissociation of cohesin from chromatin and sister chromatid separation; cleaves meiotic-cohesin subunit Rec8p along chromosome arms in meiosis I and at centromeric sites during meiosis II; inhibits PP2A-Cdc55p to promote mitotic exit; inhibited by Pds1p (securin); relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:852990" /db_xref="SGD:S000003330" ORIGIN 1 mmvkqeepln eispntpmts ksyllndtls kvhhsgqtrp ltsvlsgdas snsigilamh 61 nniirdftki asnnidlaie dittvdhsln siysllkshh mwghinstvk qhlmiivkli 121 nnnalglass eiiflfnetn lfqahslkni lladfstwnd yylsnlkila lqiilkrklv 181 deylphilel fshdkryllk dpnlkahalt kivlsffsvt tsckvlfglk flqyikqfkl 241 pfkkfisnit vecfsknllh knylemgpnk iylnsfylsy smlydgldki mlldilsyee 301 ttevqraiks kkefneycnm senrllwsci svddlnvile natnflqnkg khisatlkcl 361 vclwstirle glpknkdilr qfdctviyin sniksindes aaallsellg vlseicidyk 421 epkrlsniis vlfnasvlfk shsfllktan leisnvlisn dsktshrtil kfekfissaq 481 saqkkieifs clfnvycmlr ndtlsfvfdf cqnafihcft rlkitkfief snsseimlsv 541 lygnssieni psenwsqlsr mifcslrgif dldplelnnt fdklhllnky ellirivyll 601 nldmskhltt nlskitklyi nkwlqksdek aerissfemd fvkmllcyln fnnfdklsie 661 lslcikskek yyssivpyad nylleaylsl ymiddalmmk nqlqktmnls takieqallh 721 asslinvhlw dsdltafqiy fgktlpamkp elfdinndhn lpmslyikvi llnikifnes 781 aklnikagnv isavidcrka qnlalsllkk knklsqgsrl allkslsfsf fqlikihiri 841 gsardcefys kelsriisdl eepiivyrcl hflhryymit eqtclqnitl gkankafdyl 901 daeaditslt mflydnkefv kleqslvlyf gdqlektflp nlwklhlgkd iddsiclsey 961 mpknvinrvh nmwqkvmsql eedpffkgmf estlgipssl pvipstmpnn ilktpskhst 1021 glklcdsprs ssmtprgkni rqkfdriaai sklkqmkell eslkldtldn helskissls 1081 sltltilsni tsihnaessl itnfsltdlp rhmpllfdkv lnnidnknyr efrvssliap 1141 nnistitesi rvsaaqkdlm esnlninvit idfcpitgnl llskleprrk rrthlrlpli 1201 rsnsrdldev hlsfpeatkk llsiinesnq ttsvevtnki ktreerksww ttrydldkrm 1261 qqllnniens wfngvqgffs pevvdnslfe kfkdkfyeil hqnlpsrkly gnpamfikve 1321 dwvielflkl npqeidflsk medliyfvld illfhgeena ydeidfsmlh vqleeqikky 1381 ratmttnsif htflvvsssc hlfpweclsf lkdlsitrvp syvclnklls rfhyqlplqv 1441 tiednismil npngdlsrte skfkgmfqki idakpssqlv mnekpeeetl lkmlqnsnlf 1501 vyighgggeq yvrskeikkc tkiapsfllg cssaamkyyg kleptgtiyt yllggcpmvl 1561 gnlwdvtdkd idkfseelfe kmgfrcntdd lngnslsvsy avsksrgvch lrylngaapv 1621 iyglpikfvs // LOCUS NP_011613 688 aa linear PLN 30-JUN-2025 DEFINITION Tel2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011613 VERSION NP_011613.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181228.3 REFERENCE 1 (residues 1 to 688) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 688) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 688) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 688) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08192. On Jul 30, 2012 this sequence version replaced NP_011613.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..688 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..688 /product="Tel2p" /calculated_mol_wt="78556" Region 434..546 /region_name="Telomere_reg-2" /note="Telomere length regulation protein; pfam10193" /db_xref="CDD:462990" CDS 1..688 /gene="TEL2" /locus_tag="YGR099W" /coded_by="NM_001181228.3:1..2067" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:9490802]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:10525964]" /experiment="EXISTENCE:direct assay:GO:0110078 TTT Hsp90 cochaperone complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:3513174]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:8649421]" /experiment="EXISTENCE:mutant phenotype:GO:0034502 protein localization to chromosome [PMID:18334620]" /note="Subunit of the TTT complex and the telomere cap complex; subunit of the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation, and involved in chromatin remodeling and the telomere cap complex; DNA-binding protein specific to single-stranded yeast telomeric DNA repeats; required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1" /db_xref="GeneID:852991" /db_xref="SGD:S000003331" ORIGIN 1 mvletlkqgl dssqiheali qldsyprepv dldasmvlik fvipvypslp erskvilrrl 61 asksftflcq ivtfsrtisg rdglqeiriy qeilediisf epgcltfylk asttskadrd 121 sikalffgsk lfnvlanrid makylgylrl qwkfllesne tdppgflgew lvssfllnpv 181 laadmllgel fllkesyffs fqkiisassl idqkrliakf llpyiqvivt lenlndvrki 241 lrrfdldkii slsvlfeiqs lplkevivrl msnhsstkfv salvskfadf tdeevdtktc 301 ellvlfavhn lnhsqreeia hderflngvt khlgsnerea reramfiakl lsgghlkyes 361 dfkinipnvk fesnsddkii dfqslknpsi cntqtdvgkd kitevsghvq sltldcsdsd 421 dedenderei vkrivflkdl mkeyektges rkaplipllk qtvklirqka dfqlevgyya 481 qgilssivcl nnefdeplfe qwrinaltsi lvvlpekvng ainilfnsel slqqrmslls 541 alglsarelr glddptivkp kfdfptnrlp wddqshhnsr lvevqestsm ikktktvwks 601 rklgkdrekg tqnrfrkyag lffyplahgw lngidvgtyn qlfkshyltt lriiyscanp 661 vhdfesmtel mnhiissaie egislnkg // LOCUS NP_011614 950 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein MDR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011614 VERSION NP_011614.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181229.1 REFERENCE 1 (residues 1 to 950) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 950) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 950) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 950) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08193. Method: conceptual translation. FEATURES Location/Qualifiers source 1..950 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..950 /product="GTPase-activating protein MDR1" /calculated_mol_wt="109129" Region 23..531 /region_name="COG5210" /note="GTPase-activating protein [General function prediction only]" /db_xref="CDD:227535" Region 599..>662 /region_name="FRQ1" /note="Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; COG5126" /db_xref="CDD:444056" CDS 1..950 /gene="MDR1" /locus_tag="YGR100W" /gene_synonym="GYP2; MIC1" /coded_by="NM_001181229.1:1..2853" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:10559187]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12807768]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:35134079]" /experiment="EXISTENCE:genetic interaction:GO:0090630 activation of GTPase activity [PMID:15574876]" /note="Cytoplasmic GTPase-activating protein; activates Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function" /db_xref="GeneID:852992" /db_xref="SGD:S000003332" ORIGIN 1 msffdslrqk apfldklads ftptltrdek frlkyklpan eniledtnae vsfatsikdg 61 kghsdrvnnk grktayvysg rlfltphflv frdafdhssc vlilnistik rverspsesy 121 efallvtlyt gakvliqfig iryrseqfcd klklnlkeni pnaktlpafl etsyseflia 181 knilgkkdit vpraglgqhf kypgnptmvk ekaklrlwfd yfrengrnla vvqtpmfrkl 241 irigvpnrmr geiwelcsga mymryansge yerilnenag ktsqaideie kdlkrslpey 301 sayqteegiq rlrnvltays wknpdvgycq amnivvagfl ifmseeqafw clcnlcdiyv 361 pgyysktmyg tlldqrvfes fvedrmpvlw eyilqhdiql svvslpwfls lfftsmpley 421 avrimdiffm ngsitlfqva lavlkinadd ilqadddgmf iaiikhyfqt lgqsahpdss 481 dikyrqitkf qellvtafke fsviseemam harhkyekgi fqnietfmkr tqlrhmpktf 541 nlssddlsni ydmfyqsiet ykismgtgss nmgfevfiqf lskfcdscrp cekdkdpafr 601 kqkrnflqrl fdnwdsahig eltlndvvtg ldklvtvdll qainyffsly dtdgdgelhr 661 eevlqlsegl llltepwksg ryvdlltkkr ieddiaenii kesggeiatm nqielptgvt 721 ideekykveq aerylkaasn flqrsfeyak avdlaeevnl idlsddegee krtvkqkqle 781 sikanaaldp thpkvidlpt frmiiladet yelffsntlr ssvhvdehvn idnknkvlrs 841 mfdgiladgk rvaeqvrrrv dsvatrssia svestptaaa ssittkeeky ddlddftseh 901 qpeneellqs swfeiddane tstkaiqers feplsansse eksnliefea // LOCUS NP_011615 346 aa linear PLN 30-JUN-2025 DEFINITION rhomboid protease PCP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011615 VERSION NP_011615.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181230.1 REFERENCE 1 (residues 1 to 346) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 346) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 346) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 346) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08194. Method: conceptual translation. FEATURES Location/Qualifiers source 1..346 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..346 /product="rhomboid protease PCP1" /EC_number="3.4.21.105" /calculated_mol_wt="38684" Region 186..329 /region_name="Rhomboid" /note="Rhomboid family; pfam01694" /db_xref="CDD:426384" CDS 1..346 /gene="PCP1" /locus_tag="YGR101W" /gene_synonym="MDM37; RBD1; UGO2" /coded_by="NM_001181230.1:1..1041" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12774122]" /experiment="EXISTENCE:mutant phenotype:GO:0004252 serine-type endopeptidase activity [PMID:20558178|PMID:12774122]" /experiment="EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:12417197]" /experiment="EXISTENCE:mutant phenotype:GO:0010821 regulation of mitochondrion organization [PMID:12707284|PMID:11907266]" /note="Mitochondrial serine protease; required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases" /db_xref="GeneID:852993" /db_xref="SGD:S000003333" ORIGIN 1 msgvssvmlg lrpatriffr snisvspsrt fvsyigrsqs tsilknapnl ednvtnlqki 61 ipkrffsqts ilksrwkpif neettnryvr lnrfqqyqqq rsggnplgsm tilglslmag 121 iyfgspylfe hvppftyfkt hpknlvyall ginvavfglw qlpkcwrflq kymllqkdyv 181 tskisiigsa fshqefwhlg mnmlalwsfg tslatmlgas nffslymnsa iagslfslwy 241 pklarlaivg pslgasgalf gvlgcfsylf phakillfvf pvpggawvaf lasvawnaag 301 calrwgsfdy aahlggsmmg vlygwyiska vekqrqrrlq aagrwf // LOCUS NP_011616 183 aa linear PLN 30-JUN-2025 DEFINITION glutamyl-tRNA(Gln) amidotransferase subunit F [Saccharomyces cerevisiae S288C]. ACCESSION NP_011616 VERSION NP_011616.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181231.3 REFERENCE 1 (residues 1 to 183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 183) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08195. On Jul 30, 2012 this sequence version replaced NP_011616.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..183 /product="glutamyl-tRNA(Gln) amidotransferase subunit F" /calculated_mol_wt="20656" Region 32..160 /region_name="GatF" /note="mitochondrial glutamyl-tRNA(Gln) amidotransferase subunit F; cd21422" /db_xref="CDD:412058" Site order(32..36,39,42..43,45..46,48,50,52..54,56..57,77..86, 96..97,99..101,103..105,107..108,129,131..135,138,141..142, 145..148,150..153,155..156,158,160) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:412058" CDS 1..183 /gene="GTF1" /locus_tag="YGR102C" /coded_by="NM_001181231.3:1..552" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19417106|PMID:14562095|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex [PMID:19417106]" /experiment="EXISTENCE:direct assay:GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [PMID:19417106]" /experiment="EXISTENCE:direct assay:GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation [PMID:19417106]" /note="Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria" /db_xref="GeneID:852994" /db_xref="SGD:S000003334" ORIGIN 1 myktwrlcrt htvgglchdg shrfvstgga kigkkfenmn qirdylsrpv wsvheylgin 61 tkeeklepps aeavkkllrl sglplegadi keiqmrlakq lsfinklhni pvegekhtke 121 ydarlvqrnt kqlnytklle gishqkqdae lgevsgswka tglaaeskna yfvvkegllk 181 nrk // LOCUS NP_011617 605 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding ribosome synthesis protein NOP7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011617 VERSION NP_011617.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181232.1 REFERENCE 1 (residues 1 to 605) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 605) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 605) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 605) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08196. Method: conceptual translation. FEATURES Location/Qualifiers source 1..605 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..605 /product="mRNA-binding ribosome synthesis protein NOP7" /calculated_mol_wt="69746" Region 1..605 /region_name="NOP7" /note="Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis]; COG5163" /db_xref="CDD:227492" CDS 1..605 /gene="NOP7" /locus_tag="YGR103W" /gene_synonym="YPH1" /coded_by="NM_001181232.1:1..1818" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0070545 PeBoW complex [PMID:16287855]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12837249]" /experiment="EXISTENCE:mutant phenotype:GO:0019843 rRNA binding [PMID:12837249]" /experiment="EXISTENCE:physical interaction:GO:0070545 PeBoW complex [PMID:16287855]" /note="Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G0 and the initiation of cell proliferation" /db_xref="GeneID:852995" /db_xref="SGD:S000003335" ORIGIN 1 mrikkkntrg narnfitrsq avrklqvsla dfrrlcifkg iypreprnkk kankgstapt 61 tfyyakdiqy lmhepvlakf rehktfarkl tralgrgevs sakrleenrd sytldhiike 121 rypsfpdair diddalnmlf lfsnlpstnq vsskiindaq kicnqwlayv akerlvrkvf 181 vsikgvyyqa nikgeevrwl vpfkfpenip sdvdfrimlt flefystllh fvlyklytds 241 gliyppkldl kkdkiisgls syilesrqed sllkldptei eedvkvesld astlksalna 301 deantdetek eeeqekkqek eqekeqneet eldtfednnk nkgdiliqps kydspvaslf 361 safvfyvsre vpidilefli lscggnvise aamdqienkk didmskvthq ivdrpvlknk 421 vagrtyiqpq wifdcinkge lvpankylpg ealpphlspw gdaigydpta pveegeeees 481 esesesedqv eeedqevvag eedddddeel qaqkelelea qgikysetse adkdvnkskn 541 kkrkvdeeee ekklkmimms nkqkklykkm kysnakkeeq aenlkkkkkq iakqkaklnk 601 ldskk // LOCUS NP_011618 307 aa linear PLN 30-JUN-2025 DEFINITION Srb5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011618 VERSION NP_011618.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181233.3 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08197. On Jul 30, 2012 this sequence version replaced NP_011618.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..307 /product="Srb5p" /calculated_mol_wt="34158" Region 3..292 /region_name="Med18" /note="Med18 protein; pfam09637" /db_xref="CDD:462845" CDS 1..307 /gene="SRB5" /locus_tag="YGR104C" /gene_synonym="MED18" /coded_by="NM_001181233.3:1..924" /experiment="EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8187178]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:8324825]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0001113 transcription open complex formation at RNA polymerase II promoter [PMID:20048049]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15831453]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:23476016]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved in telomere maintenance" /db_xref="GeneID:852996" /db_xref="SGD:S000003336" ORIGIN 1 mvqqlslfgs igddgydlli stlttisgnp pllynslctv wkpnpsydve nvnsrnqlve 61 pnriklskev pfsylidetm mdkplnfril ksftndkipl nyamtrnilh ntvpqvtnfn 121 stnedqnnsk htedtvnesr nsddiidvdm daspapsnes cspwslqisd ipaagnnrsv 181 smqtiaetii lssagknssv sslmnglgyv fefqyltigv kffmkhglil elqkiwqiee 241 agnsqitsgg fllkayinvs rgtdidriny tetalmnlkk elqgyielsv pdrqsmdsrv 301 ahgnili // LOCUS NP_011619 77 aa linear PLN 30-JUN-2025 DEFINITION Vma21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011619 VERSION NP_011619.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181234.3 REFERENCE 1 (residues 1 to 77) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 77) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 77) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 77) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08198. On Jul 30, 2012 this sequence version replaced NP_011619.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..77 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..77 /product="Vma21p" /calculated_mol_wt="8304" Region 9..61 /region_name="VMA21" /note="VMA21-like domain; pfam09446" /db_xref="CDD:462801" CDS 1..77 /gene="VMA21" /locus_tag="YGR105W" /coded_by="NM_001181234.3:1..234" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9660861]" /experiment="EXISTENCE:mutant phenotype:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:9660861]" /note="Integral membrane protein required for V-ATPase function; not actual component of vacuolar H+-ATPase (V-ATPase) complex; diverged ortholog of human VMA21/XMEA (X-linked Myopathy with Excessive Autophagy); functions in assembly of V-ATPase; localizes to endoplasmic reticulum (ER)" /db_xref="GeneID:852997" /db_xref="SGD:S000003337" ORIGIN 1 mavdvpravi nklmlftaam vvlpvltffi iqqftpntli sgglaaaman vvlivyivva 61 fredtedhkv dgnkked // LOCUS NP_011620 265 aa linear PLN 30-JUN-2025 DEFINITION Voa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011620 VERSION NP_011620.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181235.1 REFERENCE 1 (residues 1 to 265) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 265) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 265) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 265) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08199. Method: conceptual translation. FEATURES Location/Qualifiers source 1..265 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..265 /product="Voa1p" /calculated_mol_wt="29547" Region 217..256 /region_name="Ac45-VOA1_TM" /note="V0 complex accessory subunit Ac45/VOA1 transmembrane domain; pfam20520" /db_xref="CDD:466669" CDS 1..265 /gene="VOA1" /locus_tag="YGR106C" /coded_by="NM_001181235.1:1..798" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:18799613]" /experiment="EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:18799613]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:18799613]" /note="ER protein that functions in assembly of the V0 sector of V-ATPase; functions with other assembly factors; null mutation enhances the vacuolar ATPase (V-ATPase) deficiency of a vma21 mutant impaired in endoplasmic reticulum (ER) retrieval" /db_xref="GeneID:852998" /db_xref="SGD:S000003338" ORIGIN 1 mvfgqlyalf iftlsccisk tvqadsskes ssfisfdkes nwdtistiss tadvissvds 61 aiavfefdnf slldnlmide eypffnrffa ndvsltvhdd splnisqsls pimeqftvde 121 lpesasdlly eyslddksiv lfkftsdayd lkkldefids clsfledksg dnltvvinsl 181 gwafededgd deyateetls hhdnnkgkeg dddilssiwt egllmclivs alllfiliva 241 lswisnldit ygalekstnp ikknn // LOCUS NP_011622 471 aa linear PLN 30-JUN-2025 DEFINITION B-type cyclin CLB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011622 VERSION NP_011622.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181237.1 REFERENCE 1 (residues 1 to 471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 471) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08200. Method: conceptual translation. FEATURES Location/Qualifiers source 1..471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..471 /product="B-type cyclin CLB1" /calculated_mol_wt="54740" Region 1..467 /region_name="COG5024" /note="Cyclin [Cell division and chromosome partitioning]" /db_xref="CDD:227357" Site order(208..209,212..213,216..217,220,292..293,296..300, 303..305,322,325..326,329..330,333..334) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410271" CDS 1..471 /gene="CLB1" /locus_tag="YGR108W" /gene_synonym="SCB1" /coded_by="NM_001181237.1:1..1416" /experiment="EXISTENCE:direct assay:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:1849458]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12972503|PMID:24223874|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12972503]" /experiment="EXISTENCE:direct assay:GO:0060631 regulation of meiosis I [PMID:18423199]" /experiment="EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:1387566]" /experiment="EXISTENCE:genetic interaction:GO:0060631 regulation of meiosis I [PMID:24223874]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:1427070]" /experiment="EXISTENCE:mutant phenotype:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:1849458]" /experiment="EXISTENCE:mutant phenotype:GO:0001932 regulation of protein phosphorylation [PMID:1849458]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:1427070]" /experiment="EXISTENCE:mutant phenotype:GO:0008315 G2/MI transition of meiotic cell cycle [PMID:8455600]" /experiment="EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:1849458]" /experiment="EXISTENCE:mutant phenotype:GO:0060631 regulation of meiosis I [PMID:24223874]" /note="B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB1 has a paralog, CLB2, that arose from the whole genome duplication" /db_xref="GeneID:853002" /db_xref="SGD:S000003340" ORIGIN 1 msrsllvens rtinsneekg vnesqyilqk rnvprtilgn vtnnanilqe ismnrkigmk 61 nfsklnnffp lkddvsradd ftssfndsrq gvkqevlnnk enipeygyse qekqqcsndd 121 sfhtnstals cnrliysenk sistqmewqk kimredskkk rpistlveqd dqkkfklhel 181 tteeevleey ewddldeedc ddplmvseev ndifdylhhl eiitlpnkan lykhknikqn 241 rdilvnwiik ihnkfgllpe tlylainimd rflceevvql nrlqlvgtsc lfiaskyeei 301 yspsikhfay etdgacsved ikegerfile kldfqisfan pmnflrrisk addydiqsrt 361 lakflmeisi vdfkfigilp slcasaamfl srkmlgkgtw dgnlihysgg ytkaklypvc 421 qllmdylvgs tihdeflkky qsrrflkasi isiewalkvr kngydimtlh e // LOCUS NP_011623 380 aa linear PLN 30-JUN-2025 DEFINITION B-type cyclin CLB6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011623 VERSION NP_011623.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181238.3 REFERENCE 1 (residues 1 to 380) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 380) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 380) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 380) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08201. On Jul 30, 2012 this sequence version replaced NP_011623.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..380 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..380 /product="B-type cyclin CLB6" /calculated_mol_wt="44014" Region 1..380 /region_name="COG5024" /note="Cyclin [Cell division and chromosome partitioning]" /db_xref="CDD:227357" Site order(119..120,123..124,127..128,131,207..208,211..215, 218..220,237,240..241,244..245,248..249) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410271" CDS 1..380 /gene="CLB6" /locus_tag="YGR109C" /coded_by="NM_001181238.3:1..1143" /experiment="EXISTENCE:direct assay:GO:0001932 regulation of protein phosphorylation [PMID:14993267]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:14993267]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8253070|PMID:8319908]" /experiment="EXISTENCE:genetic interaction:GO:0006279 premeiotic DNA replication [PMID:9732268]" /experiment="EXISTENCE:genetic interaction:GO:0045740 positive regulation of DNA replication [PMID:8319908]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8253070]" /experiment="EXISTENCE:mutant phenotype:GO:0001932 regulation of protein phosphorylation [PMID:14993267]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:9732268]" /experiment="EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:14993267]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:29263158]" /note="B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1; CLB6 has a paralog, CLB5, that arose from the whole genome duplication" /db_xref="GeneID:853003" /db_xref="SGD:S000003341" ORIGIN 1 mncipspise rkiqinnedc igkenafhti pressinltp hstnekkvls evnsnkidsl 61 qlprgklqrd sthlektrkr qlsndstdpi epktvkkikc hqwknldsie mddpfmvaey 121 tdsifshlye keiqmlpthn ylmdtqspyh lkssmralli dwlvevhekf hclpetlfla 181 inlldrflsq nvvklnklql lcitclfiac kfeevklpki tnfayvtdga atvegirkae 241 lfvlsslgyn islpnplnfi rriskadnyc ietrnmakfi meysiccnkf ihlkpsylaa 301 msmyiarkik nenskwdetf ihysggidie sdpafkdfis elvediavpd tnldslrlky 361 kkpkhgmvyf kvfdwckqkr // LOCUS NP_058162 290 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058162 VERSION NP_058162.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184380.3 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08203. On Jul 30, 2012 this sequence version replaced NP_058162.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..290 /product="gag protein" /calculated_mol_wt="33896" Region 16..206 /region_name="Ty3_capsid" /note="Ty3 transposon capsid-like protein; pfam19259" /db_xref="CDD:437091" CDS 1..290 /locus_tag="YGR109W-A" /coded_by="NM_001184380.3:1..873" /experiment="EXISTENCE:direct assay:GO:0000943 retrotransposon nucleocapsid [PMID:15956549]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:21917850]" /experiment="EXISTENCE:mutant phenotype:GO:0003677 DNA binding [PMID:21917850]" /experiment="EXISTENCE:mutant phenotype:GO:0032197 retrotransposition [PMID:17442718]" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:853005" /db_xref="SGD:S000007346" ORIGIN 1 msfmdqipgg gnypklpvec lpnfpiqpsl tfrgrndshk lknfiseiml nmsmiswpnd 61 asrivycrrh llnpaaqwan dfvqeqgile itfdtfiqgl yqhfykppdi nkifnaitql 121 seaklgierl nqrfrkiwdr mppdfmteka aimtytrllt ketynivrmh kpetlkdame 181 eayqttalte rffpgfelda dgdtiigatt hlqeeydsdy dsednltqng yvhtvrtrrs 241 ynkpmsnhrn rrnnnpsree ciknrlcfyc kkeghrlnec rarkassnrs // LOCUS NP_011624 1547 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011624 VERSION NP_011624.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184381.2 REFERENCE 1 (residues 1 to 1547) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1547) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1547) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1547) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08202. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1547 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1547 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="178290" Region 16..206 /region_name="Ty3_capsid" /note="Ty3 transposon capsid-like protein; pfam19259" /db_xref="CDD:437091" Region 286..462 /region_name="pepsin_retropepsin_like" /note="Cellular and retroviral pepsin-like aspartate proteases; cl11403" /db_xref="CDD:472175" Site order(336,338,340,364..366,405) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:133136" Site 336..338 /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:133136" Site 336 /site_type="active" /note="Catalytic residue [active]" /db_xref="CDD:133136" Site order(364..367,371..374) /site_type="active" /note="Active site flap [active]" /db_xref="CDD:133136" Region 623..797 /region_name="RT_LTR" /note="Reverse transcriptases (RTs) from retrotransposons and retroviruses which have long terminal repeats (LTRs) in their DNA copies but not in their RNA template. RT catalyzes DNA replication from an RNA template, and is responsible for the replication of...; cd01647" /db_xref="CDD:238825" Site order(686..691,720..721,746,748..749,793..794) /site_type="active" /note="putative active site [active]" /db_xref="CDD:238825" Site order(686..691,720,748) /site_type="other" /note="putative NTP binding site [chemical binding]" /db_xref="CDD:238825" Site 721 /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:238825" Region 889..1008 /region_name="RNase_HI_RT_Ty3" /note="Ty3/Gypsy family of RNase HI in long-term repeat retroelements; cd09274" /db_xref="CDD:260006" Site order(893..896,931..933,936,961,994,1008) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260006" Region 1091..1151 /region_name="Integrase_H2C2" /note="Integrase zinc binding domain; pfam17921" /db_xref="CDD:465569" Region 1167..1265 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" CDS 1..1547 /locus_tag="YGR109W-B" /coded_by="join(NM_001184381.2:1..850, NM_001184381.2:852..4645)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:853006" /db_xref="SGD:S000007347" ORIGIN 1 msfmdqipgg gnypklpvec lpnfpiqpsl tfrgrndshk lknfiseiml nmsmiswpnd 61 asrivycrrh llnpaaqwan dfvqeqgile itfdtfiqgl yqhfykppdi nkifnaitql 121 seaklgierl nqrfrkiwdr mppdfmteka aimtytrllt ketynivrmh kpetlkdame 181 eayqttalte rffpgfelda dgdtiigatt hlqeeydsdy dsednltqng yvhtvrtrrs 241 ynkpmsnhrn rrnnnpsree ciknrlcfyc kkeghrlnec rarrrvltdl eleskdqqtp 301 fiktlpivhy iaipemdnta ektikiqntk vktlfdsgsp tsfirrdive llkyeiyetp 361 plrfrgfvat ksavtseavt idlkindlhi tlaayildnm dyqllignpi lrrypkilht 421 vlntrespds lkpktyrset vnnvrtysag nrgnprnikl sfaptileat dpksagnrgd 481 srtktlslat ttpaaidplt tldnpgstqs tfaqfpipee asileedgky snvvstiqsv 541 epnatdhsnk dtfctlpvwl qqkyreiirn dlpprpadin nipvkhdiei kpgarlprlq 601 pyhvtekneq einkivqkll dnkfivpsks pcsspvvlvp kkdgtfrlcv dyrtlnkati 661 sdpfplprid nllsrignaq ifttldlhsg yhqipmepkd ryktafvtps gkyeytvmpf 721 glvnapstfa rymadtfrdl rfvnvylddi lifsespeeh wkhldtvler lknenlivkk 781 kkckfaseet eflgysigiq kiaplqhkca airdfptpkt vkqaqrflgm inyyrrfipn 841 cskiaqpiql ficdksqwte kqdkaidklk dalcnspvlv pfnnkanyrl ttdaskdgig 901 avleevdnkn klvgvvgyfs kslesaqkny pagelellgi ikalhhfrym lhgkhftlrt 961 dhisllslqn kneparrvqr wlddlatydf tleylagpkn vvadaisrav ytitpetsrp 1021 idteswksyy ksdplcsavl ihmkeltqhn vtpedmsafr syqkklelse tfrknysled 1081 emiyyqdrlv vpikqqnavm rlyhdhtlfg ghfgvtvtla kispiyywpk lqhsiiqyir 1141 tcvqcqliks hrprlhgllq plpiaegrwl dismdfvtgl pptsnnlnmi lvvvdrfskr 1201 ahfiatrktl datqlidllf ryifsyhgfp rtitsdrdvr mtadkyqelt krlgikstms 1261 sanhpqtdgq sertiqtlnr llrayastni qnwhvylpqi efvynstptr tlgkspfeid 1321 lgylpntpai ksddevnars ftavelakhl kaltiqtkeq lehaqiemet nnnqrrkpll 1381 lnigdhvlvh rdayfkkgay mkvqqiyvgp frvvkkindn ayeldlnshk kkhrvinvqf 1441 lkkfvyrpda ypknkpisst erikrahevt aligidtthk tylchmqdvd ptlsveysea 1501 efcqipertr rsilanfrql yetqdnpere edvvsqneic qydntsp // LOCUS NP_011625 445 aa linear PLN 30-JUN-2025 DEFINITION carboxylic ester hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011625 VERSION NP_011625.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181239.3 REFERENCE 1 (residues 1 to 445) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 445) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 445) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 445) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08204. On Jul 30, 2012 this sequence version replaced NP_011625.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..445 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..445 /product="carboxylic ester hydrolase" /calculated_mol_wt="51914" Region 103..439 /region_name="PLN02894" /note="hydrolase, alpha/beta fold family protein" /db_xref="CDD:215484" CDS 1..445 /gene="CLD1" /locus_tag="YGR110W" /coded_by="NM_001181239.3:1..1338" /experiment="EXISTENCE:direct assay:GO:0004623 phospholipase A2 activity [PMID:19244244]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19244244]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:23637464]" /experiment="EXISTENCE:direct assay:GO:0032048 cardiolipin metabolic process [PMID:19244244]" /experiment="EXISTENCE:genetic interaction:GO:0032048 cardiolipin metabolic process [PMID:19244244]" /experiment="EXISTENCE:mutant phenotype:GO:0004623 phospholipase A2 activity [PMID:19244244]" /experiment="EXISTENCE:mutant phenotype:GO:0035965 cardiolipin acyl-chain remodeling [PMID:23637464|PMID:19244244]" /note="Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58" /db_xref="GeneID:853007" /db_xref="SGD:S000003342" ORIGIN 1 mfkstlnsii rrplkgfqll rgadssntrp qsprasardv tekqilrtps aptaiplrei 61 iyrvpslfpr pledsvkdfr dfiknedafq tellktlpfy ptpsesktar lirtvvddeg 121 nyinefcirp rktsvpeadl khlvfihgyg aglgffiknf ediplldnew cihaidlpgy 181 gfssrpkfpf eyprdnihsv qdwfheriht wfskrnllnr peknivmahs lgsylmalyl 241 qkykespsfk klilcspagv syrdfnntas evekwkpppw wyvklwdrni spftlvrnfr 301 qlgskitsgw syrrfkhiln gdpeqskrfe alhryayaif nkrgsgeyll sfalkcggep 361 rlsleqqlfd gkksdilkns ncdwlwlygd ddwmdvnggl rvsrflkekl kqksnviivp 421 hsghhlyldn ykffnniltk emqki // LOCUS NP_011626 400 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR111W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011626 VERSION NP_011626.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181240.1 REFERENCE 1 (residues 1 to 400) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 400) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 400) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 400) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08205. Method: conceptual translation. FEATURES Location/Qualifiers source 1..400 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..400 /product="uncharacterized protein" /calculated_mol_wt="46537" CDS 1..400 /locus_tag="YGR111W" /coded_by="NM_001181240.1:1..1203" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /db_xref="GeneID:853008" /db_xref="SGD:S000003343" ORIGIN 1 mtassndddl ifecysdpel krwthlanak awkgiltvqq yadreqllgs seisqknksn 61 emmtkypksy qwlgqkyfvl kdrslpdngk fsqvvsscet lnrigycihp gsngkiepal 121 ivciggvftf enhrgkgyak kmiiklnefy dkirddantv lelknlvinl ysevgeyysa 181 lgyesmhvpl hriskldelt erycgedddh dgkylgfddy rglvglhetq fkesllslhk 241 enpekfvftv apdfdiftwf qyrdlfimnk sgrkaqqnlf fgyalsdnsh iiwhhnwngd 301 sliivkihip eetfqrkelk lkkllrkaie etklhglqel efwdeeipik kypqlfqllt 361 eleneskvfs engsisavrp pkgytaeqvi wdnntkfcwf // LOCUS NP_011627 389 aa linear PLN 30-JUN-2025 DEFINITION cytochrome oxidase assembly protein SHY1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011627 VERSION NP_011627.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181241.1 REFERENCE 1 (residues 1 to 389) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 389) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 389) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 389) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08206. Method: conceptual translation. FEATURES Location/Qualifiers source 1..389 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..389 /product="cytochrome oxidase assembly protein SHY1" /calculated_mol_wt="44925" Region 78..353 /region_name="SURF1" /note="SURF1 family; pfam02104" /db_xref="CDD:460447" CDS 1..389 /gene="SHY1" /locus_tag="YGR112W" /coded_by="NM_001181241.1:1..1170" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15306853|PMID:9162072]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15306853]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:17882259]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:11389896]" /note="Mitochondrial inner membrane protein required for complex IV assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome; complex IV is also known as cytochrome c oxidase; also localizes to the peroxisome" /db_xref="GeneID:853009" /db_xref="SGD:S000003344" ORIGIN 1 msllgarsty rwfsiaasip tknaigksty llasrnqqyr giitstvdwk piktgkspnd 61 dsrrersfgk kivlglmfam piisfylgtw qvrrlkwktk liaacetklt yepiplpksf 121 tpdmcedwey rkviltghfl hneemfvgpr kkngekgyfl ftpfirddtg ekvliergwi 181 seekvapdsr nlhhlslpqe ehlkvvclvr ppkkrgslqw akkdpnsrlw qvpdiydmar 241 ssgctpiqfq alydmkdhpi ieehtrneas qnnstsslwk fwkrepttav ngtqavdnnt 301 skprsrqemp tdqtiefder qfikagvpig rkptidlknn hlqylvtwyg lsflstifli 361 valrkakrgg vvsqdqlmke klkhsrkym // LOCUS NP_011628 343 aa linear PLN 30-JUN-2025 DEFINITION Dam1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011628 VERSION NP_011628.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181242.3 REFERENCE 1 (residues 1 to 343) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 343) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 343) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 343) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08207. On Jul 30, 2012 this sequence version replaced NP_011628.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..343 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..343 /product="Dam1p" /calculated_mol_wt="38291" Region 63..118 /region_name="DASH_Dam1" /note="DASH complex subunit Dam1; pfam08653" /db_xref="CDD:430133" CDS 1..343 /gene="DAM1" /locus_tag="YGR113W" /coded_by="NM_001181242.3:1..1032" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:16777964|PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15640796|PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:20479465|PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479465|PMID:20479468]" /experiment="EXISTENCE:direct assay:GO:0071459 protein localization to chromosome, centromeric region [PMID:30903360]" /experiment="EXISTENCE:direct assay:GO:0098653 centromere clustering [PMID:30903360]" /note="Essential subunit of the Dam1 complex (aka DASH complex); cooperates with Duo1p and Pse1p to connect the DASH complex with the microtubules (MT); couples kinetochores to the force produced by MT depolymerization, thereby aiding in chromosome segregation; N-terminal staple region is important for self-assembly of the Dam1 complex higher order ring structure that forms around microtubules; Ipl1p target for regulating kinetochore-MT attachments" /db_xref="GeneID:853010" /db_xref="SGD:S000003345" ORIGIN 1 msedkaklgt trsateyrls igsaptsrrs smgessslmk fadqegltss vgeynentiq 61 qlllpkirel sdsiitldsn ftrlnfihes ladlneslgs llygimsnsw cvefsqaphd 121 iqddliaikq lksledeknn lvmelsnmer gikrkkdeqg endlakasqn kqfnqplfps 181 sqvrkyrsyd nrdkrkpski gnnlqvenee dyeddtssea sfvlnptnig mskssqghvt 241 kttrlnnntn sklrrksilh tirnsiasga dlpiendnvv nlgdlhpnnr islgsgaarv 301 vngpvtknrn smfsgraerk ptesrhsvak ktekkintrp pfr // LOCUS NP_011631 1451 aa linear PLN 30-JUN-2025 DEFINITION chromatin-remodeling histone chaperone SPT6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011631 VERSION NP_011631.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181245.1 REFERENCE 1 (residues 1 to 1451) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1451) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1451) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1451) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08208. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1451 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1451 /product="chromatin-remodeling histone chaperone SPT6" /calculated_mol_wt="168161" Region 28..128 /region_name="SPT6_acidic" /note="Acidic N-terminal SPT6; pfam14632" /db_xref="CDD:464226" Region 336..445 /region_name="HTH_44" /note="Helix-turn-helix DNA-binding domain of SPT6; pfam14641" /db_xref="CDD:464230" Region 744..895 /region_name="YqgF" /note="Holliday-junction resolvase-like of SPT6; pfam14639" /db_xref="CDD:258777" Region 897..1000 /region_name="HHH_7" /note="Helix-hairpin-helix motif; pfam14635" /db_xref="CDD:291309" Region 1232..1436 /region_name="SH2_2" /note="SH2 domain; pfam14633" /db_xref="CDD:464227" CDS 1..1451 /gene="SPT6" /locus_tag="YGR116W" /gene_synonym="CRE2; SSN20" /coded_by="NM_001181245.1:1..4356" /experiment="EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:15531585]" /experiment="EXISTENCE:direct assay:GO:0001073 transcription antitermination factor activity, DNA binding [PMID:15531585]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2201908]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:8633238]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:21094070]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:22308335]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:8633238]" /experiment="EXISTENCE:genetic interaction:GO:0001073 transcription antitermination factor activity, DNA binding [PMID:15531585]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:8633238]" /experiment="EXISTENCE:genetic interaction:GO:0031440 regulation of mRNA 3'-end processing [PMID:15531585]" /experiment="EXISTENCE:genetic interaction:GO:0031564 transcription antitermination [PMID:15531585]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:20502685]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16455495]" /experiment="EXISTENCE:mutant phenotype:GO:0001073 transcription antitermination factor activity, DNA binding [PMID:15531585]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:8633238]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:19620280|PMID:18086892|PMID:20502685|PMID:6392016]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:19034519]" /experiment="EXISTENCE:mutant phenotype:GO:0031440 regulation of mRNA 3'-end processing [PMID:15531585]" /experiment="EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:21094070]" /experiment="EXISTENCE:mutant phenotype:GO:0031564 transcription antitermination [PMID:15531585]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:19620280]" /experiment="EXISTENCE:mutant phenotype:GO:0034728 nucleosome organization [PMID:21098123]" /experiment="EXISTENCE:mutant phenotype:GO:1902597 positive regulation of DNA replication origin binding [PMID:36924499]" /experiment="EXISTENCE:mutant phenotype:GO:1902975 mitotic DNA replication initiation [PMID:36924499]" /note="Histone chaperone; regulates chromatin structure, transcription, mRNA 3'-end formation and genome stability; role in chromatin remodeling and nucleosome assembly; required for initiation of DNA replication, promoting origin licensing through MCM helicase loading; required for fidelity of promoter selection through maintenance of chromatin structure during transcription; required for H3K36 trimethylation but not dimethylation by Set2p" /db_xref="GeneID:853011" /db_xref="SGD:S000003348" ORIGIN 1 meetgdsklv prdeeeivnd ndetkapsee eegedvfdss eededidede dearkvqegf 61 ivndddened pgtsiskkrr khkrrereed drlseddldl lmenagvert kassssgkfk 121 rlkrvgdegn aaesesdnva asrqdstskl edffsedeee eesglrngrn neygrdeedh 181 enrnrtadkg gildelddfi eddefsdedd etrqrriqek kllreqsikq ptqitglssd 241 kidemydifg dghdydwale ieneelengn dnneaeeeei deetgaikst kkkislqdiy 301 dledlkknlm tegdmkirkt diperyqelr agitdygnms sedqelernw iaekisvdkn 361 fdanydltef keaignaikf itkenlevpf iyayrrnyis srekdgfllt eddlwdivsl 421 diefhslvnk kdyvqrfyae lhiddpivte yfknqntasi aelnslqdiy dylefkyane 481 inemfinhtg ktgkkhlkns syekfkaspl yqavsdigis aedvgeniss qhqihppvdh 541 psskpvevie silnansgdl qvftsntkla idtvqkyysl elskntkire kvrsdfskyy 601 ladvvltakg kkeiqkgsly edikyainrt pmhfrrdpdv flkmveaesl nllsvklhms 661 sqaqyiehlf qialettnts diaiewnnfr klafnqamdk ifqdisqevk dnltkncqkl 721 vaktvrhkfm tkldqapfip nvrdpkipki lsltcgqgrf gadaiiavyv nrkgdfirdy 781 kivdnpfdkt npekfedtld niiqscqpna igingpnpkt qkfykrlqev lhkkqivdsr 841 ghtipiiyve devairyqns eraaqefpnk pplvkycial arymhsplle yanltseevr 901 slsihphqnl lsseqlswal etafvdivnl vsvevnkatd nnyyasalky isgfgkrkai 961 dflqslqrln epllarqqli thnilhktif mnsagflyis wnekrqkyed lehdqldstr 1021 ihpedyhlat kvaadaleyd pdtiaekeeq gtmsefiell redpdrrakl eslnlesyae 1081 elekntglrk lnnlntivle lldgfeelrn dfhplqgdei fqsltgesek tffkgsiipv 1141 rverfwhndi icttnsevec vvnaqrhaga qlrrpaneiy eigktypakv iyidyanita 1201 evslldhdvk qqyvpisysk dpsiwdlkqe ledaeeerkl mmaearakrt hrvinhpyyf 1261 pfngrqaedy lrskergefv irqssrgddh lvitwkldkd lfqhidiqel ekenplalgk 1321 vlivdnqkyn dldqiiveyl qnkvrllnem tssekfksgt kkdvvkfied ysrvnpnksv 1381 yyfslnhdnp gwfylmfkin ansklytwnv kltntgyflv nynypsviql cngfktllks 1441 nssknrmnny r // LOCUS NP_011632 476 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR117C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011632 VERSION NP_011632.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181246.3 REFERENCE 1 (residues 1 to 476) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 476) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 476) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 476) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08209. On Jul 30, 2012 this sequence version replaced NP_011632.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..476 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..476 /product="uncharacterized protein" /calculated_mol_wt="53307" Region 12..39 /region_name="LisH" /note="Lissencephaly type-1-like homology motif; smart00667" /db_xref="CDD:128913" CDS 1..476 /locus_tag="YGR117C" /coded_by="NM_001181246.3:1..1431" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:853014" /db_xref="SGD:S000003349" ORIGIN 1 madnstsrfy tnllianylk hngledtlaa firetalpls aleksdssns nvgeipledl 61 qsvvedriyy krrsfkdrfk tlsinddlap idnakygiqp wnhslkfsid vklnkslpkd 121 tlfisatfte dskyillssa tgylviydie katsksfkin ekvksivkly gpigssgyqy 181 vcpmngsfyl lnndfelvnn avwkiharmi thikicnvte sswfvitsgm dnflrlslle 241 ikngntfltk lseiklasnc tslnviangd gngqnsfsvf ltraeythia cysiidaknl 301 vhsynialnn aefstyafni rdvmavdyvh sntkdtigls pstmlvvats hkpymrlilv 361 eipmntghpk amkldkvqty ydkilrnfat eiyqddfslp ilgklessng vlvgndegiy 421 svdlmtgdsr ilnipgeans lhdrikcmdi skdqmrmvag tstksiyiln virnaq // LOCUS NP_011633 145 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS12 RPS23A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011633 VERSION NP_011633.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181247.3 REFERENCE 1 (residues 1 to 145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 145) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08210. On Jul 30, 2012 this sequence version replaced NP_011633.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..145 /product="40S ribosomal protein uS12 RPS23A" /calculated_mol_wt="15907" Region 4..145 /region_name="PTZ00067" /note="40S ribosomal S23; Provisional" /db_xref="CDD:185422" Site order(28,30..34,36,38..43,45..51,62..70,76..78,86,88..91, 104..110,113..116,122..123,128,130,140..142) /site_type="other" /note="18S rRNA interaction site [nucleotide binding]" /db_xref="CDD:239465" Site order(62..63,114) /site_type="other" /note="streptomycin interaction site [chemical binding]" /db_xref="CDD:239465" Site 63..64 /site_type="other" /note="28S rRNA interaction site [nucleotide binding]" /db_xref="CDD:239465" Site order(64..69,90..98) /site_type="other" /note="aminoacyl-tRNA interaction site (A-site) [nucleotide binding]" /db_xref="CDD:239465" Site 99 /site_type="other" /note="eEF2 interaction site [polypeptide binding]" /db_xref="CDD:239465" CDS 1..145 /gene="RPS23A" /locus_tag="YGR118W" /coded_by="NM_001181247.3:1..438" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:genetic interaction:GO:0006450 regulation of translational fidelity [PMID:7498767|PMID:8415737|PMID:8950190]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:8415737|PMID:7498767|PMID:8950190]" /note="Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23A has a paralog, RPS23B, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal" /db_xref="GeneID:853015" /db_xref="SGD:S000003350" ORIGIN 1 mgkgkprgln sarklrvhrr nnrwaennyk krllgtafks spfggsshak givleklgie 61 skqpnsairk cvrvqlikng kkvtafvpnd gclnfvdend evllagfgrk gkakgdipgv 121 rfkvvkvsgv sllalwkekk ekprs // LOCUS NP_011634 541 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin NUP57 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011634 VERSION NP_011634.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181248.1 REFERENCE 1 (residues 1 to 541) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 541) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 541) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 541) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08211. Method: conceptual translation. FEATURES Location/Qualifiers source 1..541 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..541 /product="FG-nucleoporin NUP57" /calculated_mol_wt="57368" Region 19..>237 /region_name="Nucleoporin_FG2" /note="Nucleoporin FG repeated region; pfam15967" /db_xref="CDD:435043" Region 326..462 /region_name="Nup54" /note="Nucleoporin complex subunit 54; pfam13874" /db_xref="CDD:464011" CDS 1..541 /gene="NUP57" /locus_tag="YGR119C" /coded_by="NM_001181248.1:1..1626" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0017056 structural constituent of nuclear pore [PMID:19680227]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406|PMID:24574455|PMID:9813081]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:17875746|PMID:11387327]" /experiment="EXISTENCE:genetic interaction:GO:0036228 protein localization to nuclear inner membrane [PMID:21659568]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:9725905]" /experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:9725905|PMID:14960378]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788]" /note="FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p)" /db_xref="GeneID:853016" /db_xref="SGD:S000003351" ORIGIN 1 mfgfsgsnng fgnkpagstg fsfgqnnnnt ntqpsasgfg fggsqpnsgt attggfganq 61 atntfgsnqq sstggglfgn kpalgslgss sttasgttat gtglfgqqta qpqqstiggg 121 lfgnkptttt gglfgnsaqn nsttsgglfg nkvgstgslm ggnstqntsn mnagglfgak 181 pqnttattgg lfgskpqgst tngglfgsgt qnnntlgggg lfgqsqqpqt ntapglgntv 241 stqpsfawsk pstgsnlqqq qqqqiqvplq qtqaiaqqqq lsnypqqiqe qvlkckeswd 301 pnttktklra fvynkvnete ailytkpghv lqeewdqame kkpspqtipi qiygfeglnq 361 rnqvqtenva qariilnhil ekstqlqqkh eldtasrilk aqsrnveiek rilklgtqla 421 tlknrglplg iaeekmwsqf qtllqrsedp aglgktnelw arlailkera knissqldsk 481 lmvfnddtkn qdsmskgtge esndrinkiv eiltnqqrgi tylnevlekd aaivkkyknk 541 t // LOCUS NP_011635 262 aa linear PLN 30-JUN-2025 DEFINITION Golgi transport complex subunit COG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011635 VERSION NP_011635.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181249.1 REFERENCE 1 (residues 1 to 262) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 262) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 262) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 262) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 262) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 262) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 262) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 262) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08212. On Oct 2, 2003 this sequence version replaced NP_011635.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..262 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..262 /product="Golgi transport complex subunit COG2" /calculated_mol_wt="30194" Region 41..154 /region_name="COG2" /note="COG (conserved oligomeric Golgi) complex component, COG2; cl19297" /db_xref="CDD:473160" CDS 1..262 /gene="COG2" /locus_tag="YGR120C" /gene_synonym="SEC35" /coded_by="NM_001181249.1:1..789" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10512869]" /experiment="EXISTENCE:mutant phenotype:GO:0000301 retrograde transport, vesicle recycling within Golgi [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20065092]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20065092]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /note="Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; the components of the Golgi complex are Gog1p through Cog8p" /db_xref="GeneID:853017" /db_xref="SGD:S000003352" ORIGIN 1 mdflnddeld ldlpvtaeis kelfateiek yresetngtd vdnfdvdrfl vqknfhylpl 61 dslirdlsgl sqkmvqtlle qirsnyddyl tfsntytdee netlinlekt qsdlqkfmtq 121 ldhlikddis ntqeiikdvl eylkkldeiy gslrnhsqlt ealslgkrls kslhemcgie 181 pleeeicsgl ieqlyklita srrilescad snspyihhlr ndyqdllqef qislkiltek 241 clenpsslqn lsltlvsiik ta // LOCUS NP_011636 492 aa linear PLN 30-JUN-2025 DEFINITION ammonium permease MEP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011636 VERSION NP_011636.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181250.3 REFERENCE 1 (residues 1 to 492) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 492) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 492) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 492) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08213. On Jul 30, 2012 this sequence version replaced NP_011636.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..492 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..492 /product="ammonium permease MEP1" /calculated_mol_wt="54071" Region 19..424 /region_name="amt" /note="ammonium transporter; TIGR00836" /db_xref="CDD:273292" CDS 1..492 /gene="MEP1" /locus_tag="YGR121C" /gene_synonym="AMT1" /coded_by="NM_001181250.3:1..1479" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:26172854]" /experiment="EXISTENCE:direct assay:GO:0008519 ammonium channel activity [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0008519 ammonium channel activity [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:9234685]" /note="Ammonium permease; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation; activity regulated by TORC1 effectors, Npr1p and Par32p; human homolog RHCG complements yeast null mutant; mutations in human homolog RHCG implicated in metabolic acidosis; MEP1 has a paralog, MEP3, that arose from the whole genome duplication" /db_xref="GeneID:853019" /db_xref="SGD:S000003353" ORIGIN 1 mesrttgplt tetydgptva fmilgaalvf fmvpglgfly sglarrksal aliwvvlmat 61 lvgilqwyfw gyslafsksa pnnkfignld sfgfrnvygk kfdedaypel ayatfqmmfs 121 cvnlsiiaga taergrllph mvflfilati gycpvtywiw spggwayqwg vldwagggni 181 eilsavsgfv yswflgkrne kllinfrphn vslvtlgtsi lwfgwllfns asslspnlrs 241 vyafmntcls aitggmtwcl ldyrsekkws tvglcsgiis glvaatpssg citlygsliq 301 givagvvcnf atklkyyakv ddamdilaeh gvagviglif nalfgadwvi gmdgtteheg 361 gwvthnykqm ykqiayiaas igytaavtai icfvlgyipg mrlriseeae eagmdedqig 421 efaydyvevr rdyylwgvde dsqrsdvnhr vnnahlaaer sssgtnsssd gngemiqsek 481 ilpihqedpa nr // LOCUS NP_878078 71 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR121W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878078 VERSION NP_878078.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184551.1 REFERENCE 1 (residues 1 to 71) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 71) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 71) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 71) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 71) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 71) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 71) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 71) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08214. Method: conceptual translation. FEATURES Location/Qualifiers source 1..71 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..71 /product="uncharacterized protein" /calculated_mol_wt="7897" CDS 1..71 /locus_tag="YGR121W-A" /coded_by="NM_001184551.1:1..216" /note="hypothetical protein" /db_xref="GeneID:1466458" /db_xref="SGD:S000028550" ORIGIN 1 msrhkyklwm ciakgkrgvg erntfvpkcs yapfcasevl dqllrgdnsi vynfylkngs 61 gsvyigsvfl i // LOCUS NP_011637 402 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR122W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011637 VERSION NP_011637.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181251.3 REFERENCE 1 (residues 1 to 402) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 402) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 402) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 402) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08215. On Jul 30, 2012 this sequence version replaced NP_011637.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..402 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..402 /product="uncharacterized protein" /calculated_mol_wt="45174" Region 80..402 /region_name="DUF5355" /note="Family of unknown function (DUF5355); pfam17306" /db_xref="CDD:435852" CDS 1..402 /locus_tag="YGR122W" /coded_by="NM_001181251.3:1..1209" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15879523|PMID:16024810]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:17660569]" /note="Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress" /db_xref="GeneID:853020" /db_xref="SGD:S000003354" ORIGIN 1 mrenamstkk lpyklsgssk ittsipndli ilrnncinsl nsssskadsi tcidtwlkyt 61 egllthryea nndaalieee iaialinvav fyqdigietl yrayessqas nnlwttsgty 121 lkrglglicf lgknfqinta ndcqkmqvln vlnqlslefq llqqlgivvl alsklrskis 181 kdavadlepq eleelgkssv fyaklcigsy stasqcqggr ivdalfmnyl qsltylflsi 241 nqynndecgi aigmlqesik kllnivpnsq lkeldilsst ditkkrdlik msfkrkihgs 301 tlknqrifek kvpfsskaym mpllkssldd fvipltillr yryqttneny sfktvetdvs 361 klkelfprgk ssdiegtvws fqdghltfad snnathncgn yf // LOCUS NP_011639 513 aa linear PLN 30-JUN-2025 DEFINITION protein serine/threonine phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011639 VERSION NP_011639.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181252.3 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08216. On Jul 30, 2012 this sequence version replaced NP_011639.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..513 /product="protein serine/threonine phosphatase" /EC_number="3.1.3.16" /calculated_mol_wt="57864" Region 10..>130 /region_name="PLN03088" /note="SGT1, suppressor of G2 allele of SKP1; Provisional" /db_xref="CDD:215568" Region 12..40 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(13,16..17,20..21,23,47,50..51,54..55,57..58,81, 84..85,88..89,92) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 45..75 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 80..108 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 165..508 /region_name="MPP_PP5_C" /note="PP5, C-terminal metallophosphatase domain; cd07417" /db_xref="CDD:277362" Site order(249,251,278,281..282,310..311,359,393,407,434,458) /site_type="active" /db_xref="CDD:277362" Site order(249,251,278,310,359,434) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277362" Site order(282,320,404,406..408,458,461) /site_type="other" /note="TPR interaction site [polypeptide binding]" /db_xref="CDD:277362" CDS 1..513 /gene="PPT1" /locus_tag="YGR123C" /coded_by="NM_001181252.3:1..1542" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:12694636]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12694636]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12694636]" /experiment="EXISTENCE:direct assay:GO:0006470 protein dephosphorylation [PMID:7925273]" /note="Protein serine/threonine phosphatase; regulates Hsp90 chaperone by affecting its ATPase and cochaperone binding activities; has similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth" /db_xref="GeneID:853023" /db_xref="SGD:S000003355" ORIGIN 1 mstptaadra kalerknegn vfvkekhflk aiekyteaid ldstqsiyfs nrafahfkvd 61 nfqsalndcd eaikldpkni kayhrralsc mallefkkar kdlnvllkak pndpaatkal 121 ltcdrfiree rfrkaiggae neakislcqt lnlssfdana dlanyegpkl efeqlyddkn 181 afkgakiknm sqefiskmvn dlflkgkylp kkyvaaiish adtlfrqeps mvelennstp 241 dvkisvcgdt hgqfydvlnl frkfgkvgpk htylfngdfv drgswsceva llfyclkilh 301 pnnfflnrgn hesdnmnkiy gfedeckyky sqrifnmfaq sfeslplatl inndylvmhg 361 glpsdpsatl sdfknidrfa qpprdgafme llwadpqean gmgpsqrglg hafgpditdr 421 flrnnklrki frshelrmgg vqfeqkgklm tvfsapnycd sqgnlggvih vvpghgilqa 481 grnddqnlii etfeavehpd ikpmaysngg fgl // LOCUS NP_011640 572 aa linear PLN 30-JUN-2025 DEFINITION asparagine synthase (glutamine-hydrolyzing) 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011640 VERSION NP_011640.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181253.1 REFERENCE 1 (residues 1 to 572) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 572) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 572) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 572) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08217. Method: conceptual translation. FEATURES Location/Qualifiers source 1..572 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..572 /product="asparagine synthase (glutamine-hydrolyzing) 2" /EC_number="6.3.5.4" /calculated_mol_wt="64462" Region 1..561 /region_name="asnB" /note="asparagine synthetase B; Provisional; PRK09431" /db_xref="CDD:236513" CDS 1..572 /gene="ASN2" /locus_tag="YGR124W" /coded_by="NM_001181253.1:1..1719" /experiment="EXISTENCE:direct assay:GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity [PMID:6105958]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006529 asparagine biosynthetic process [PMID:8951815]" /note="Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN2 has a paralog, ASN1, that arose from the whole genome duplication" /db_xref="GeneID:853025" /db_xref="SGD:S000003356" ORIGIN 1 mcgifaafkh edihnfkpka lqlskkirhr gpdwsgnavm nstifvherl aivgldsgaq 61 pitsadgeym lgvngeiynh iqlremcsdy kfqtfsdcep iiplylehdi dapkyldgmf 121 afclydskkd rivaardpig vvtlymgrss qspetvyfas elkcltdvcd siisfppghv 181 ydsetdkitr yftpdwldek ripstpvdyh airhslekav rkrlmaevpy gvllsgglds 241 sliaaiaare tekanadane dnnvdekqla giddqghlht sgwsrlhsfa iglpnapdlq 301 aarkvakfig sihhehtftl qegldalddv iyhletydvt tirastpmfl lsrkikaqgv 361 kmvlsgegsd eifggylyfa qapsaaefht esvqrvknlh ladclranks tmawglearv 421 pfldkdflql cmnidpnekm ikpkegriek yilrkafdtt depdvkpylp eeilwrqkeq 481 fsdgvgyswi dglrdtaera isdamfanpk adwgddiptt keaywyrlkf dawfpqktaa 541 dtvmrwipka dwgcaedpsg ryakihekhv sa // LOCUS NP_011641 1036 aa linear PLN 30-JUN-2025 DEFINITION Vsb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011641 VERSION NP_011641.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181254.1 REFERENCE 1 (residues 1 to 1036) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1036) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1036) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1036) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1036) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1036) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1036) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1036) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08218. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1036 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1036 /product="Vsb1p" /calculated_mol_wt="116841" Region 206..606 /region_name="Sulfate_transp" /note="Sulfate permease family; pfam00916" /db_xref="CDD:459995" Region 667..769 /region_name="STAS_SulP_like_sulfate_transporter" /note="Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042" /db_xref="CDD:132913" Region 910..1014 /region_name="CAP_ED" /note="effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038" /db_xref="CDD:237999" Site order(966..967,977..978,981) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:237999" Site order(1001..1003,1007..1009) /site_type="other" /note="flexible hinge region" /db_xref="CDD:237999" CDS 1..1036 /gene="VSB1" /locus_tag="YGR125W" /coded_by="NM_001181254.1:1..3111" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:33704406]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:32776922]" /experiment="EXISTENCE:mutant phenotype:GO:0034490 basic amino acid transmembrane import into vacuole [PMID:32776922]" /experiment="EXISTENCE:mutant phenotype:GO:0034618 arginine binding [PMID:33704406]" /note="Vacuolar membrane protein required for uptake and storage of arginine in nitrogen-replete cells; nitrogen starvation appears to inhibit Vsb1-dependent activity, resulting in mobilization of stored vacuolar arginine to the cytosol; arginine uptake appears to be driven by a V-ATPase mediated H+ gradient; member of the APC (amino acid-polyamine-organocation) transporter superfamily" /db_xref="GeneID:853026" /db_xref="SGD:S000003357" ORIGIN 1 mgrtirrrrs nsslseaisv slginqdssv nkmhrasvsa mspplcrsym sgfftggnsp 61 minnlsdskl pisnkqhpkv ihgsenlhrq taqlsnefcs ssveenspti kdymdiigng 121 drkddqsmrt ieenideeys deysrlllsp assnvdddrn rglqnsslpe ledgyaggyq 181 slrpshnlrf rprnlwhmct sfpskfahyl paavlgllln ildalsygmi ifpitepvfs 241 hlgptgismf yistiisqav ysggwssfps gigsemieit pfyhtmalai kealagndde 301 iitttifcyv issmltgvvf yalgklrlgk ivgffprhil igciggvgyf liitgievtt 361 rvakfeyswp ffsglftdyd tlakwllpvl ltvvligtqr yfknslvlps fyiltlvlfh 421 fivaiiptls ldalrqagwi fpiansdskw ydhyrlfnvh kvhwslvlqq iptmmaltff 481 gilhvpinvp alamslqmdk ydvdreliah gysnffsgll gsvqnylvyt nsvlfiraga 541 dspfagflli alticimiig pviisfipic ivgslifllg yellvealvd twnklnrfey 601 ltvviivftm gifdfvlgii vgiliacfsf lvdstklqti ngeyngnvar stvyrdyvqt 661 kfldgigeqi yvlklqnllf fgtiisieek ierllqisnk datkrrikyl ildfkninad 721 nidysaaegf nrikrftetk rikliissik erdriynafn nvgllndvel fadlnsalew 781 ceneflfqyk qlrkkakerl eegkqnnvvs aviaatknkk idtignglnr gsngdtarnl 841 mslptntprn yqilsvaqnv fvndeqavkn fkkeykddep vlpillfalk qyrpdiisev 901 qkvrekeikf waqlcpyftr rrlasqshll hadnifflve tgmlkatyel pqgtlyeifs 961 ngtcfgkiia pgnampreqk ltietetdsv lwvidsssln klkednlaly vevalmvmci 1021 kdtrfkellg ytlvsa // LOCUS NP_011642 230 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR126W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011642 VERSION NP_011642.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181255.3 REFERENCE 1 (residues 1 to 230) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 230) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 230) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 230) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08219. On Jul 30, 2012 this sequence version replaced NP_011642.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..230 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..230 /product="uncharacterized protein" /calculated_mol_wt="25714" CDS 1..230 /locus_tag="YGR126W" /coded_by="NM_001181255.3:1..693" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:853027" /db_xref="SGD:S000003358" ORIGIN 1 mpvpsvtvtt dneyedissf ssidsykpep ftgfkdseap eqpllkndti vgkgqledds 61 nvddqhrhsd vhshhssstl krptsnsiek mvthnalegn setvdslked glnlnkkalp 121 ditapvtnsa hdaafpeeyr letetglvkl ktleslkred srvsstkkeh indhtdmhst 181 rskvttnsqg sslepnklnm aveknkkrie kyqkhksekg ikgffhrifd // LOCUS NP_011643 312 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR127W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011643 VERSION NP_011643.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181256.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08220. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..312 /product="uncharacterized protein" /calculated_mol_wt="35554" Region 1..289 /region_name="TANGO2" /note="Transport and Golgi organization 2; pfam05742" /db_xref="CDD:461729" CDS 1..312 /locus_tag="YGR127W" /coded_by="NM_001181256.1:1..939" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /note="Protein involved in heme trafficking to the nucleus; expression is regulated by Msn2p/Msn4p, indicating possible role in stress response; localizes to cytosol and peroxisomes" /db_xref="GeneID:853028" /db_xref="SGD:S000003359" ORIGIN 1 mcilmatrah pdyelilisn rdeflarkth atcwhnndfi lspydlakts aekqifgtws 61 ginkegklat ilnlkldneq nntksrsrgl lpfiflsihk adfedwdnyk kfeghydglk 121 stgdfnffyg dvikkqykvi dslgrtfdvl sstcrkdlds ymvvsngkfy dsssipgqaw 181 ekvkvardsl enlvlenies deekiisscf qlasksslps tisnpdvlqm vdpnvtmnti 241 yvpplrrppr ddlgasipdg dyygtrsqiv llvskdstrv tfiervlyss dedvrkysvt 301 spkeekrfkf kl // LOCUS NP_011644 713 aa linear PLN 30-JUN-2025 DEFINITION Utp8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011644 VERSION NP_011644.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181257.3 REFERENCE 1 (residues 1 to 713) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 713) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 713) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 713) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08221. On Jul 30, 2012 this sequence version replaced NP_011644.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..713 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..713 /product="Utp8p" /calculated_mol_wt="80060" Region 1..713 /region_name="Utp8" /note="Utp8 family; pfam10395" /db_xref="CDD:402149" CDS 1..713 /gene="UTP8" /locus_tag="YGR128C" /coded_by="NM_001181257.3:1..2142" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:19370060]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:15489292]" /experiment="EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:12794079]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]" /note="Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" /db_xref="GeneID:853029" /db_xref="SGD:S000003360" ORIGIN 1 mpslsqpfrl atlpkiasls nfslqadyvq vadgtfnest nnitlgisgs sisqyiinpt 61 pkltfdypip stniitacna ekgqanidgn ieastddean nektintqkk rnveiwafgl 121 mvnkgnytln vitkaledtt dtsndhlses didnkaytgs deflsqykik akakvmsiki 181 dtknslviai lqnglieifd fkltllhsfd isydnlkyak wftengteyv fvlcplqddk 241 vcyklleltd cgsgesspik elsstiiegf sfensklcyq fgklyklnqg kiyiyslphc 301 qlqqviefpm vdklspgddl isfqpvsvnr vlltvnnviy lldllhcstl sqrelthvkt 361 fqllksavin sekshnskti aigistkngp nptssleiin idvgtntlkd slgksfqvgn 421 ndssvilkpl fddkdindkr vkcndvsgds svpvlhcnev ieklsalqdn ditsfddiff 481 kelkikeehy tekdryisdp gflnkvldli fgkfsgndyp ktltfllthp lfplsrtrnl 541 lsllrdqprl fkqaivtcpn lplnelleel fsirnrelll disfrilqdf trdsikqemk 601 klskldvqnf iefitsgged sspecfnpsq stqlfqllsl vldsiglfsl egallenltl 661 yidkqveiae rntelwnlid tkgfqhgfas stfdngtsqk ralptytmey ldi // LOCUS NP_011645 215 aa linear PLN 30-JUN-2025 DEFINITION Syf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011645 VERSION NP_011645.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181258.3 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08222. On Jul 30, 2012 this sequence version replaced NP_011645.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..215 /product="Syf2p" /calculated_mol_wt="24672" Region 60..209 /region_name="SYF2" /note="SYF2 splicing factor; pfam08231" /db_xref="CDD:462400" CDS 1..215 /gene="SYF2" /locus_tag="YGR129W" /gene_synonym="NTC31" /coded_by="NM_001181258.3:1..648" /experiment="EXISTENCE:curator inference:GO:0000384 first spliceosomal transesterification activity [PMID:11105756|PMID:11842115]" /experiment="EXISTENCE:curator inference:GO:0000386 second spliceosomal transesterification activity [PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:11842115]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:11842115|PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0071008 U2-type post-mRNA release spliceosomal complex [PMID:11105756]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:11105756]" /note="Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest" /db_xref="GeneID:853030" /db_xref="SGD:S000003361" ORIGIN 1 mdfykldekl kelkrkrvdv siksrkladr eiqevsanrk prvysmedvn dadesvgdte 61 spekekafhy tvqeydawer rhpqgktgqs qrggisydql aklsyektlr nlatqtqnss 121 kqdssadeed nknvpkkgri gkvqkdtktg kitiadddkl vnklavslqs eskkryeark 181 rqmqnaktly gvesfindkn kqfneklsre skgse // LOCUS NP_011646 816 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR130C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011646 VERSION NP_011646.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181259.1 REFERENCE 1 (residues 1 to 816) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 816) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 816) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 816) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08223. Method: conceptual translation. FEATURES Location/Qualifiers source 1..816 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..816 /product="uncharacterized protein" /calculated_mol_wt="92567" Region <520..>776 /region_name="Smc" /note="Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; COG1196" /db_xref="CDD:440809" CDS 1..816 /locus_tag="YGR130C" /coded_by="NM_001181259.1:1..2451" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:19064668|PMID:19269952]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:33443082]" /experiment="EXISTENCE:mutant phenotype:GO:0097446 protein localization to eisosome filament [PMID:33443082]" /note="Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7)" /db_xref="GeneID:853031" /db_xref="SGD:S000003362" ORIGIN 1 mlfninrqed dpftqlinqs santqnqqah qqespyqflq kvvsnepkgk eewvspfrqd 61 alanrqnnra ygedaknrkf ptvsatsays kqqpkdlgyk nipknakrak dirfptyltq 121 neerqyqllt elelkekhlk ylkkcqkitd ltkdekddtd tttssststs ssssssssss 181 sssssdegdv tstttseate atadtatttt tttststtst sttnavensa deatsveeeh 241 edkvsestsi gkgtadsaqi nvaepissen gvleprttdq sggsksgvvp tdeqkeeksd 301 vkkvnppsge ekkeveaegd aeeeteqssa eesaertstp etsepeseed espidpskap 361 kvpfqepsrk ertgifalwk sptssstqks ktaapsnpva tpenpelivk tkehgylska 421 vydkinydek ihqawladlr akekdkydak nkeykeklqd lqnqideien smkamreets 481 ekievsknrl vkkiidvnae hnnkklmilk dtenmknqkl qeknevldkq tnvkseiddl 541 nnektnvqke fndwttnlsn lsqqldaqif kinqinlkqg kvqneidnle kkkedlvtqt 601 eenkklhekn vqvlesvenk eylpqindid nqissllnev tiikqenane ktqlsaitkr 661 lederrahee qlkleaeerk rkeenllekq rqeleeqahq aqldheqqit qvkqtyndql 721 telqdklate ekeleavkre rtrlqaekai eeqtrqknad ealkqeilsr qhkqaegiha 781 aenhkipndr sqkntsvlpk ddslyeyhte edvmya // LOCUS NP_011647 174 aa linear PLN 30-JUN-2025 DEFINITION Fhn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011647 VERSION NP_011647.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181260.1 REFERENCE 1 (residues 1 to 174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 174) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08224. Method: conceptual translation. FEATURES Location/Qualifiers source 1..174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..174 /product="Fhn1p" /calculated_mol_wt="19021" Region 6..138 /region_name="MARVEL" /note="Membrane-associating domain; pfam01284" /db_xref="CDD:366555" CDS 1..174 /gene="FHN1" /locus_tag="YGR131W" /coded_by="NM_001181260.1:1..525" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0072659 protein localization to plasma membrane [PMID:20581291]" /note="hypothetical protein; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain; FHN1 has a paralog, NCE102, that arose from the whole genome duplication" /db_xref="GeneID:853032" /db_xref="SGD:S000003363" ORIGIN 1 mlsaadnlvr iinavfliis iglisgligt qtkhssrvnf cmfaavyglv tdslygflan 61 fwtsltypai llvldflnfi ftfvaatala vgirchsckn ktyleqnkii qgsssrchqs 121 qaavaffyfs cflflikvtv atmgmmqngg fgsntgfsrr rarrqmgipt isqv // LOCUS NP_011648 287 aa linear PLN 30-JUN-2025 DEFINITION prohibitin subunit PHB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011648 VERSION NP_011648.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181261.3 REFERENCE 1 (residues 1 to 287) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 287) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 287) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 287) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08225. On Jul 30, 2012 this sequence version replaced NP_011648.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..287 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..287 /product="prohibitin subunit PHB1" /calculated_mol_wt="31296" Region 29..223 /region_name="SPFH_prohibitin" /note="Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; cd03401" /db_xref="CDD:259799" CDS 1..287 /gene="PHB1" /locus_tag="YGR132C" /coded_by="NM_001181261.3:1..864" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:9259555|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10835343|PMID:9632789]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:10835343]" /experiment="EXISTENCE:genetic interaction:GO:0007007 inner mitochondrial membrane organization [PMID:19221197]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:12882345]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:19221197]" /experiment="EXISTENCE:mutant phenotype:GO:0007007 inner mitochondrial membrane organization [PMID:19221197]" /experiment="EXISTENCE:mutant phenotype:GO:0045861 negative regulation of proteolysis [PMID:10207067]" /note="Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)" /db_xref="GeneID:853033" /db_xref="SGD:S000003364" ORIGIN 1 msnsaklidv itkvalpigi iasgiqysmy dvkggsrgvi fdringvkqq vvgegthflv 61 pwlqkaiiyd vrtkpksiat ntgtkdlqmv sltlrvlhrp evlqlpaiyq nlgldyderv 121 lpsignevlk sivaqfdaae litqreiisq kirkelstra nefgikledv sithmtfgpe 181 ftkaveqkqi aqqdaerakf lvekaeqerq asviraegea esaefiskal akvgdgllli 241 rrleaskdia qtlanssnvv ylpsqhsggg nsessgspns lllnigr // LOCUS NP_011649 183 aa linear PLN 30-JUN-2025 DEFINITION E2 ubiquitin-protein ligase peroxin 4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011649 VERSION NP_011649.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181262.1 REFERENCE 1 (residues 1 to 183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 183) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08226. Method: conceptual translation. FEATURES Location/Qualifiers source 1..183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..183 /product="E2 ubiquitin-protein ligase peroxin 4" /EC_number="2.3.2.23" /calculated_mol_wt="20987" Region 20..176 /region_name="UBCc_ScPEX4-like" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of Saccharomyces cerevisiae Peroxin-4 (PEX4) protein and related proteins; cd23812" /db_xref="CDD:467432" CDS 1..183 /gene="PEX4" /locus_tag="YGR133W" /gene_synonym="PAS2; UBC10" /coded_by="NM_001181262.1:1..552" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:17452527|PMID:22085930]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:1326082]" /experiment="EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:17452527|PMID:24034674]" /experiment="EXISTENCE:direct assay:GO:0051865 protein autoubiquitination [PMID:17452527]" /experiment="EXISTENCE:mutant phenotype:GO:0006513 protein monoubiquitination [PMID:17452527]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:2568633]" /experiment="EXISTENCE:mutant phenotype:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:17452527]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]" /note="Peroxisomal ubiquitin conjugating enzyme; required for peroxisomal matrix protein import and peroxisome biogenesis" /db_xref="GeneID:853034" /db_xref="SGD:S000003365" ORIGIN 1 mpnfwilenr rsytsdtcms rivkeykvil ktlasddpia npyrgiiesl npidetdlsk 61 weaiisgpsd tpyenhqfri lievpssypm nppkisfmqn nilhcnvksa tgeiclnilk 121 peewtpvwdl lhcvhavwrl lrepvcdspl dvdigniirc gdmsayqgiv kyflaereri 181 nnh // LOCUS NP_011650 1122 aa linear PLN 30-JUN-2025 DEFINITION CCR4-NOT core subunit CAF130 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011650 VERSION NP_011650.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181263.3 REFERENCE 1 (residues 1 to 1122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1122) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08227. On Jul 30, 2012 this sequence version replaced NP_011650.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1122 /product="CCR4-NOT core subunit CAF130" /calculated_mol_wt="128650" CDS 1..1122 /gene="CAF130" /locus_tag="YGR134W" /coded_by="NM_001181263.3:1..3369" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:11733989]" /note="Subunit of the CCR4-NOT transcriptional regulatory complex; CCR4-NOT complex is evolutionarily-conserved and involved in controlling mRNA initiation, elongation, and degradation" /db_xref="GeneID:853035" /db_xref="SGD:S000003366" ORIGIN 1 mtkkkaatny aerqnlased ssgdsvhfkd fiplqellkd knyvpsvenl ekilynetmf 61 ndqkicsnll lealiitlft tisgksalrl iqtsslkerk swaqsfenns ssyasivlsw 121 kdndilllkf lrfllankta plqinrynlp eyklplsfli vskitipsil lnetynllkd 181 ylysitgrie sliscsstfd kpalvvrkil kdynrmiecr nfyfwysfna enrvnltfsd 241 nisllmende gnagsgldds rfdhqkqpre aimgrtindq eqiysfelnq dgtleipnvm 301 ehsllrhell fkilnlttvl tpllelqfst lcglvdplmq ptpndkhiis idflfqlflg 361 lmsqsiktsq ehndhydwkf ymcfnmqkii datmlrlncf dfdilnsvnn tdnavhwktq 421 lhrwlphgln tqdlellymi dilavytiyk lyekipiqln pflfslislw knlscvilla 481 leidrieeen gtyetplmvr atirgaaalr sviatvlngl vknndhdfkh eslntfmspy 541 grklchgaly adlrshtasl lalgasiedv tdlfadlqsg drfdedirym fdyecedyde 601 sfsesdhggl desvvnptek iasgsnnvff rrrcncifnd dklvaedgan eafgstnsen 661 vegamhnnrn avhnattats dhvvtspnpl svrsrstfef dysgedwrdv prdfnmyysp 721 sysfihepkl dvifsltlrg ateklnkees illvrsvasc vrneqdqmil adlesnfsas 781 ingdvegegn tkmskidned lrrttpddiy eiwseesafe rmlnvnhdva wrlmdemlmc 841 tgyrriliwf lthlelkhsl iyyvfelimg lrgkpfsgea sdqdkkddmi yeilkkkqkn 901 edasglpfsr qgpivlsdie tkmllqeffm naaiflsskn neeenedgek islyslglvr 961 licymvqtli andkffftks ectfelqtll mtwigilpea kdlffkiktr lameeedsad 1021 tmqhegrkns diekklnakp aselnlklln lfpskpankd dsspintlrs fiadysfdtq 1081 vnppgrrvvf ydgkilplpk adkpiplhey itlaeldvgd se // LOCUS NP_011651 258 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit alpha 3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011651 VERSION NP_011651.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181264.3 REFERENCE 1 (residues 1 to 258) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 258) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 258) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 258) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08228. On Jul 30, 2012 this sequence version replaced NP_011651.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..258 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..258 /product="proteasome core particle subunit alpha 3" /calculated_mol_wt="28583" Region 4..216 /region_name="proteasome_alpha_type_4" /note="The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming...; cd03752" /db_xref="CDD:239721" Site order(8..11,13..14,16..17,21,24,27..28,31,39,54,56..57, 81..83,85..86,117,120,123..124,127..131,149,154..155,157, 159..160,162) /site_type="other" /note="alpha subunit interaction site [polypeptide binding]" /db_xref="CDD:239721" Site order(33,49,51,65,167) /site_type="active" /db_xref="CDD:239721" CDS 1..258 /gene="PRE9" /locus_tag="YGR135W" /coded_by="NM_001181264.3:1..777" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019773 proteasome core complex, alpha-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:19029916|PMID:11545745]" /experiment="EXISTENCE:mutant phenotype:GO:0080129 proteasome core complex assembly [PMID:14739934]" /note="Alpha 3 subunit of the 20S proteasome; the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform" /db_xref="GeneID:853036" /db_xref="SGD:S000003367" ORIGIN 1 mgsrrydsrt tifspegrly qveyalesis hagtaigima sdgivlaaer kvtstlleqd 61 tsteklykln dkiavavagl tadaeilint arihaqnylk tynedipvei lvrrlsdikq 121 gytqhgglrp fgvsfiyagy ddrygyqlyt snpsgnytgw kaisvgants aaqtllqmdy 181 kddmkvddai elalktlskt tdssaltydr lefatirkga ndgevyqkif kpqeikdilv 241 ktgitkkded eeadedmk // LOCUS NP_011652 241 aa linear PLN 30-JUN-2025 DEFINITION Lsb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011652 VERSION NP_011652.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181265.1 REFERENCE 1 (residues 1 to 241) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 241) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 241) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 241) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08229. Method: conceptual translation. FEATURES Location/Qualifiers source 1..241 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..241 /product="Lsb1p" /calculated_mol_wt="26008" Region 55..108 /region_name="SH3" /note="Src homology 3 domains; smart00326" /db_xref="CDD:214620" Site order(62,64,67,71,89..90,103,105..106) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212690" Region <100..>156 /region_name="PRK12323" /note="DNA polymerase III subunit gamma/tau; cl46901" /db_xref="CDD:481241" CDS 1..241 /gene="LSB1" /locus_tag="YGR136W" /coded_by="NM_001181265.1:1..726" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276|PMID:22842922|PMID:23577202]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:23577202]" /experiment="EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:23577202]" /experiment="EXISTENCE:physical interaction:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:23577202]" /note="Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication" /db_xref="GeneID:853037" /db_xref="SGD:S000003368" ORIGIN 1 msaslvnrsl knirnelefl kesnvisgdi felinsklpe kwdgnqrspq nadteeyvea 61 lydfeaqqdg dlslktgdki qvlekispdw yrgksnnkig ifpanyvkpa ftrsaspksa 121 eaassstvsr psvpppsyep aasqypsqqv sapyappagy mqapppqqqq aplpypppft 181 nyyqqpqqqy appsqqapve aqpqqssgas safksfgskl gnaaifgags aigsdivnsi 241 f // LOCUS NP_011654 614 aa linear PLN 30-JUN-2025 DEFINITION spermine transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_011654 VERSION NP_011654.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181267.1 REFERENCE 1 (residues 1 to 614) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 614) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 614) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 614) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08230. Method: conceptual translation. FEATURES Location/Qualifiers source 1..614 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..614 /product="spermine transporter" /calculated_mol_wt="67458" Region 173..599 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(183..184,187..188,191,223,273..274,276..278,281,301, 304..305,308,410,413..414,417..419,422,446,450,519..520, 524,528,543,546..547,550..551,554) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..614 /gene="TPO2" /locus_tag="YGR138C" /coded_by="NM_001181267.1:1..1845" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12562762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000296 spermine transport [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0000297 spermine transmembrane transporter activity [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11171066]" /note="Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; TPO2 has a paralog, TPO3, that arose from the whole genome duplication" /db_xref="GeneID:853039" /db_xref="SGD:S000003370" ORIGIN 1 msdqesvvsf nsqntsmvdv egqqpqqyvp sktnsranql kltktetvks lqdlgvtsaa 61 pvpdinapqt aknnifpeey tmetpsglvp vatlqsmgrt asalsrtrtk qlnrtatnss 121 stgkeemeee eteeredqsg eneldpeief vtfvtgdpen phnwpswvrw sytvllsilv 181 icvaygsaci sgglgtvekk yhvgmeaail scslmvigfs lgpliwspvs dlygrrvayf 241 vsmglyvifn ipcalapnlg cllacrflcg vwsssglclv ggsiadmfps etrgkaiaff 301 afapyvgpvv gplvngfisv stgrmdlifw vnmafagvmw iissaipety apvilkrkaa 361 rlrketgnpk imteqeaqgv smsemmracl lrplyfavte pvlvatcfyv cliysllyaf 421 ffafpvifge lygykdnlvg lmfipiviga lwalattfyc enkylqivkq rkptpedrll 481 gakigapfaa ialwilgata ykhiiwvgpa saglafgfgm vliyyslnny iidcyvqyas 541 salatkvflr saggaafplf tiqmyhklnl hwgswllafi stamialpfa fsywgkglrh 601 klskkdysid svem // LOCUS NP_011656 956 aa linear PLN 30-JUN-2025 DEFINITION Cbf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011656 VERSION NP_011656.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181269.3 REFERENCE 1 (residues 1 to 956) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 956) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 956) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 956) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 956) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 956) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 956) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 956) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08231. On Jul 30, 2012 this sequence version replaced NP_011656.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..956 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..956 /product="Cbf2p" /calculated_mol_wt="111787" Region 29..506 /region_name="Ndc10" /note="Ndc10 component of the yeast centromere-binding factor 3; cd11602" /db_xref="CDD:211427" Site order(203..204,326..328,333..334,336..337,341,353,355..356) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:211427" Region 843..922 /region_name="GCR1_C" /note="Transcriptional activator of glycolytic enzymes; pfam12550" /db_xref="CDD:432628" CDS 1..956 /gene="CBF2" /locus_tag="YGR140W" /gene_synonym="CEP2; CSL5; CTF14; NDC10" /coded_by="NM_001181269.3:1..2871" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:9407032]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:16381814]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:10097110]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:9407032]" /experiment="EXISTENCE:direct assay:GO:0031518 CBF3 complex [PMID:8706132|PMID:1997204|PMID:8670864]" /experiment="EXISTENCE:direct assay:GO:0051233 spindle midzone [PMID:12566427]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:16381814]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:16330709]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:8486732]" /note="Essential kinetochore protein; component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo; sumoylated in an Mms21p-dependent manner; relative distribution to the spindle pole body decreases upon DNA replication stress" /db_xref="GeneID:853041" /db_xref="SGD:S000003372" ORIGIN 1 mrssilfllk lmkimdvqqq qeamssedrf qelvdslkpr tahqyktyyt kyiqwcqlnq 61 iiptpednsv nsvpykdlpi saelihwfll dtlitddkpg ekreetedld eeeensfkia 121 tlkkiigsln flsklckvhe npnanidtky lesvtklhth widsqkaitt netnntntqv 181 lcppllkvsl nlwnpetnhl sekffktcse klrflvdfql rsylnlsfee rskirfgslk 241 lgkrdrdaii yhkvthsaek kdtpghhqll allpqdcpfi cpqttlaayl ylrfygipsv 301 skgdgfpnln adengsllqd ipilrgkslt typreetfsn yyttvfrych lpykrreyfn 361 kcnlvyptwd edtfrtffne enhgnwleqp eafafpdkip fdfkkimnfk spytsystna 421 kkdpfpppkd llvqifpeid eykrhdyegl sqnsrdfldl mevlrerfls nlpwiykffp 481 nhdifqdpif gnsdfqsyfn dktihskgsp ilsfdilpgf nkiyknktnf ysllierpsq 541 ltfasshnpd thptqkqese gplqmsqldt tqlnellkqq sfeyvqfqtl snfqillsvf 601 nkifeklemk kssrgyilhq lnlfkitlde rikkskidda dkfirdnqpi kkeenivned 661 gpntsrrtkr pkqirllsia dssdessted snvfkkdges iedgaygene dendsemqeq 721 lksminelin skistflrdq mdqfelkina lldkileekv triieqklgs htgkfstlkr 781 pqlymteehn vgfdmevpkk lrtsgkyaet vkdnddhqam sttaspspeq dqeaksytde 841 qefmldksid siegiilewf tpnakyanqc vhsmnksgnk swrancealy kerksivefy 901 iylvnhesld rykavdicek lrdqnegsfs rlakflrkwr hdhqnsfdgl lvylsn // LOCUS NP_011657 467 aa linear PLN 30-JUN-2025 DEFINITION Vps62p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011657 VERSION NP_011657.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181270.1 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08232. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..467 /product="Vps62p" /calculated_mol_wt="54384" Region <202..>297 /region_name="Vps62" /note="Vacuolar protein sorting-associated protein 62; pfam06101" /db_xref="CDD:461828" CDS 1..467 /gene="VPS62" /locus_tag="YGR141W" /coded_by="NM_001181270.1:1..1404" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /note="Vacuolar protein sorting (VPS) protein; required for cytoplasm to vacuole targeting of proteins; targeted to vacuole via AP-3 pathway; VPS62 has a paralog, TDA6, that arose from the whole genome duplication" /db_xref="GeneID:853042" /db_xref="SGD:S000003373" ORIGIN 1 mrisknshkr qrtrlyflvt fiiysiipcr avlvpwlddd pfeatllemg depwskdils 61 stpplhpsev tednkslkqr gnvpqyvidn spllhlysee kywpadvkdf vkrfqlrdhs 121 gekiinehlr dlsdlqeyys velengtwgr vssegtymts lddfdkgpdw llgeqpeygt 181 ghikkapavl fvvdkgngwv dafwfyfypf nwgpyimgsg pwgnhvgdwe hslvrfykge 241 pqylwmsahg ggsaykfeai ekikrlrrvd gkltnevikk plifsargth ahyasvgqha 301 hdvpfffmpl sdftdrgplw dpslnyyayt vtvgekmtpc gaeetkmgle wlsfkgawgd 361 kqlrprdprq kwcpfqwkyi dgpkgplfkn mervslcqrf kwwnfwkgcp arryikrgeg 421 ldaekndlvg dncgillyni rpkwlrsilr fltwrgsvcf imdyftg // LOCUS NP_011658 410 aa linear PLN 30-JUN-2025 DEFINITION Btn2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011658 VERSION NP_011658.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181271.3 REFERENCE 1 (residues 1 to 410) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 410) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 410) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 410) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08233. On Jul 30, 2012 this sequence version replaced NP_011658.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..410 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..410 /product="Btn2p" /calculated_mol_wt="47037" Region <262..402 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" Region <262..>329 /region_name="tolA_full" /note="TolA protein; TIGR02794" /db_xref="CDD:274303" CDS 1..410 /gene="BTN2" /locus_tag="YGR142W" /coded_by="NM_001181271.3:1..1233" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:17101785]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22718905]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:17101785]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11053386|PMID:22718905]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:18833194]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:22718905]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:22718905]" /experiment="EXISTENCE:mutant phenotype:GO:0006865 amino acid transport [PMID:15701790]" /experiment="EXISTENCE:mutant phenotype:GO:0006885 regulation of pH [PMID:11053386|PMID:15701790]" /experiment="EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:12615067|PMID:22718905]" /experiment="EXISTENCE:mutant phenotype:GO:0034504 protein localization to nucleus [PMID:22718905]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:17101785]" /experiment="EXISTENCE:mutant phenotype:GO:0140311 protein sequestering activity [PMID:31649258]" /experiment="EXISTENCE:physical interaction:GO:0000149 SNARE binding [PMID:17101785]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0006886 intracellular protein transport [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0034504 protein localization to nucleus [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0051087 protein-folding chaperone binding [PMID:22718905]" /note="Compartment-specific sequestrase chaperone; small hsp that sequesters proteins at intranuclear quality control sites (INQs); sumoylated form promotes protein clearance from INQs during recovery from genotoxic stress; v-SNARE binding protein that mediates late endosome-Golgi protein sorting; modulates arginine uptake and pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; role in prion curing; expression after severe ethanol stress is involved in clearance of denatured proteins" /db_xref="GeneID:853043" /db_xref="SGD:S000003374" ORIGIN 1 mfsifnspcv feqlpsfsqp lhsryfdcss pvsyypeckr rkaikanlra pkksdancse 61 plryalaetp ngytlslskr ipyelfskyv neklgelken hyrptyhvvq dffgnqyyve 121 deadedallr salkdldfra igkkiakdlf qdyeielnhr gdelsilskk dkifkefsld 181 qvfedvfvig cgveniddgs rekyallkig lvkheeeise gginepkmpi ieskideshd 241 dvnmseslke eeaekakepl tkedqikkwi eeerlmqees rkseqekaak edeerqkkek 301 earlkarkes linkqktkrs qqkklqnsks lpiseieasn knnnsnsgsa esdnesinsd 361 sdttldfsvs gntlkkhasp lledvedeev dryneslsrs pkgnsiieei // LOCUS NP_011659 771 aa linear PLN 30-JUN-2025 DEFINITION beta-glucan synthesis-associated protein SKN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011659 VERSION NP_011659.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181272.3 REFERENCE 1 (residues 1 to 771) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 771) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 771) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 771) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 771) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 771) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 771) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 771) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08234. On Jul 30, 2012 this sequence version replaced NP_011659.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..771 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..771 /product="beta-glucan synthesis-associated protein SKN1" /calculated_mol_wt="86110" Region 249..763 /region_name="SKN1_KRE6_Sbg1" /note="Beta-glucan synthesis-associated protein SKN1/KRE6/Sbg1; pfam03935" /db_xref="CDD:397841" CDS 1..771 /gene="SKN1" /locus_tag="YGR143W" /coded_by="NM_001181272.3:1..2316" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:7929594]" /experiment="EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:20030721]" /experiment="EXISTENCE:genetic interaction:GO:0030148 sphingolipid biosynthetic process [PMID:15792805]" /experiment="EXISTENCE:mutant phenotype:GO:0006078 (1->6)-beta-D-glucan biosynthetic process [PMID:7929594]" /experiment="EXISTENCE:mutant phenotype:GO:0015926 glucosidase activity [PMID:10601196]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:15792805]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:7929594]" /note="Protein involved in sphingolipid biosynthesis; type II membrane protein; SKN1 has a paralog, KRE6, that arose from the whole genome duplication" /db_xref="GeneID:853045" /db_xref="SGD:S000003375" ORIGIN 1 msvrnltnnr hsnsensvsg sensfyssne qsrqssslep adgqnvrvsg npflgseefd 61 edynspsgdd errganeyss sssinynndp nsdtsllane knsperngqr msdykgyyak 121 tnltsannln nhnnnnykni isssndnsfa shlqppdrnl pshpssnnms sfsnnsliks 181 pppfdryplv gtrhisaaqs qsqnlinekk ranmtgssss ahdsslsstn lymgeqdfsp 241 fggypasffp ltldekeddd yihnpnveee akldrrrfvd dfkhmdrrsf lgllgilflf 301 magififivl paitfsgvvy hhehvhaans agssssntts kslteyqypq laairttlvd 361 pdtpdsaktr vakdgskwql vfsdefnaeg rtfydgddqf wtapdihyda tkdlewyspd 421 avtttngtlt lrmdafrnhd lyyrsgmvqs wnklcftega levsanlpny grvtglwpgm 481 wtmgnlgrpg ylastqgvwp ysyeacdagi tpnqsspdgi sylpgqklsv ctcdnedhpn 541 qgvgrgapei dilegeadti lgvgvasqsl qiapfdiwym pdydfievyn fttttmntya 601 ggpfqqavsa istlnvtwye fgeeagyfqk yaieylnddd ngyirwfvge nptftlyats 661 lhpsgnidwr riskepmsai lnlgisnnwa yidwqyiffp vtmsidyvrl yqpkgstsit 721 cdpedyptyd yiqshlnayy nanltdweqa gytfpknilt ggcssskfsl s // LOCUS NP_011660 326 aa linear PLN 30-JUN-2025 DEFINITION thiamine thiazole synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011660 VERSION NP_011660.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181273.1 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08235. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..326 /product="thiamine thiazole synthase" /EC_number="2.4.2.60" /calculated_mol_wt="34860" Region 45..325 /region_name="TIGR00292" /note="thiazole biosynthesis enzyme" /db_xref="CDD:273001" CDS 1..326 /gene="THI4" /locus_tag="YGR144W" /gene_synonym="ESP35; MOL1" /coded_by="NM_001181273.1:1..981" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16850348|PMID:15544818]" /experiment="EXISTENCE:direct assay:GO:0008198 ferrous iron binding [PMID:22031445]" /experiment="EXISTENCE:direct assay:GO:0052837 thiazole biosynthetic process [PMID:22031445]" /experiment="EXISTENCE:direct assay:GO:0160205 cysteine-dependent adenosine diphosphate thiazole synthase activity [PMID:22031445]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:9367751]" /experiment="EXISTENCE:mutant phenotype:GO:0009228 thiamine biosynthetic process [PMID:7941734]" /note="Thiazole synthase; abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a single turnover only; required for mitochondrial genome stability in response to DNA damaging agents" /db_xref="GeneID:853047" /db_xref="SGD:S000003376" ORIGIN 1 msatstatst sasqlhlnst pvthclsdiv kkedwsdfkf apirestvsr amtsryfkdl 61 dkfavsdvii vgagssglsa ayviaknrpd lkvciiessv apgggswlgg qlfsamvmrk 121 pahlflqele ipyedegdyv vvkhaalfis tvlskvlqlp nvklfnatcv edlvtrppte 181 kgevtvagvv tnwtlvtqah gtqccmdpnv ielagykndg trdlsqkhgv ilsttghdgp 241 fgafcakriv didqnqklgg mkgldmnhae hdvvihsgay agvdnmyfag mevaeldgln 301 rmgptfgama lsgvhaaeqi lkhfaa // LOCUS NP_011661 707 aa linear PLN 30-JUN-2025 DEFINITION ribosome biosynthesis protein ENP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011661 VERSION NP_011661.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181274.2 REFERENCE 1 (residues 1 to 707) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 707) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 707) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 707) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08236. On Apr 26, 2011 this sequence version replaced NP_011661.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..707 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..707 /product="ribosome biosynthesis protein ENP2" /calculated_mol_wt="81603" Region <153..316 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 183..225 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 232..267 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 274..309 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 479..507 /region_name="NUC153" /note="NUC153 domain; pfam08159" /db_xref="CDD:462385" CDS 1..707 /gene="ENP2" /locus_tag="YGR145W" /coded_by="NM_001181274.2:1..2124" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15590835|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:24357410]" /experiment="EXISTENCE:mutant phenotype:GO:0032040 small-subunit processome [PMID:24357410]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:19806183]" /note="Component of the SSU; required for pre-18S rRNA processing, biogenesis of the small ribosomal subunit; interacts with U3 snoRNA, Mpp10p and Bfr2p; contains WD repeats, and has homology to Spb1p" /db_xref="GeneID:853048" /db_xref="SGD:S000003377" ORIGIN 1 mvlkstsand vsvyqvsgtn vsrslpdwia kkrkrqlknd leyqnrveli qdfefseasn 61 kikvsrdgqy cmatgtykpq ihvydfanls lkfdrhtdae nvdftilsdd wtksvhlqnd 121 rsiqfqnkgg lhyttripkf grslvynkvn cdlyvgasgn elyrlnlekg rflnpfkldt 181 egvnhvsine vngllaagte tnvvefwdpr srsrvsklyl ennidnrpfq vtttsfrndg 241 ltfacgtsng ysyiydlrts epsiikdqgy gfdikkiiwl dnvgtenkiv tcdkriakiw 301 drldgkayas mepsvdindi ehvpgtgmff tanesipmht yyipslgpsp rwcsfldsit 361 eeleekpsdt vysnyrfitr ddvkklnlth lvgsrvlray mhgffintel ydkvslianp 421 daykderere irrriekere srirssgavq kpkikvnktl vdklsqkrgd kvagkvltdd 481 rfkemfedee fqvdeddydf kqlnpvksik eteegaakri raltaaeesd eeriamkdgr 541 ghydyedees deeesddetn qksnkeelse kdlrkmekqk alierrkkek eqserfmnem 601 kagtststqr desahvtfge qvgelleven gkksnesilr rnqrgeaelt fipqrkskkd 661 gnyksrrhdn ssdeegiden gnkkdngrsk prfenrrras knafrgm // LOCUS NP_011662 211 aa linear PLN 30-JUN-2025 DEFINITION Ecl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011662 VERSION NP_011662.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181275.3 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08237. On Jul 30, 2012 this sequence version replaced NP_011662.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..211 /product="Ecl1p" /calculated_mol_wt="23866" Region 5..>92 /region_name="Ecl1" /note="ECL1/2/3 zinc binding proteins; pfam12855" /db_xref="CDD:432834" CDS 1..211 /gene="ECL1" /locus_tag="YGR146C" /coded_by="NM_001181275.3:1..636" /note="hypothetical protein; mitochondrial-dependent role in the extension of chronological lifespan; overexpression increases oxygen consumption and respiratory activity while deletion results in reduced oxygen consumption under conditions of caloric restriction; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation" /db_xref="GeneID:853049" /db_xref="SGD:S000003378" ORIGIN 1 mstafndyct vcdrliptsp qktnintrki qrdnetkssl qsnklycsed cklkdsnpln 61 ekllshlhkk sktshshnlt pplsysknlt asnlfeptts lsssptssti pfdelekles 121 llisplllpq dgivnpkqes npsrvdeyde nehylnlads lrldssyqlh skahlgyenn 181 lprsndlidd hlisdqiien nynlwfrlss s // LOCUS NP_878079 53 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR146C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878079 VERSION NP_878079.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184594.1 REFERENCE 1 (residues 1 to 53) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 53) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 53) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 53) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08238. Method: conceptual translation. FEATURES Location/Qualifiers source 1..53 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..53 /product="uncharacterized protein" /calculated_mol_wt="5919" CDS 1..53 /locus_tag="YGR146C-A" /coded_by="NM_001184594.1:1..162" /note="hypothetical protein" /db_xref="GeneID:1466459" /db_xref="SGD:S000028638" ORIGIN 1 mgflpecnlt cafllhsftf piahcpsfsw asffftirpp ffpklalvct ifs // LOCUS NP_011663 288 aa linear PLN 30-JUN-2025 DEFINITION Nat2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011663 VERSION NP_011663.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181276.3 REFERENCE 1 (residues 1 to 288) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 288) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 288) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 288) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08239. On Jul 30, 2012 this sequence version replaced NP_011663.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..288 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..288 /product="Nat2p" /calculated_mol_wt="32673" Region 93..221 /region_name="FAM210A-B_dom" /note="FAM210A/B-like domain; pfam06916" /db_xref="CDD:429191" CDS 1..288 /gene="NAT2" /locus_tag="YGR147C" /coded_by="NM_001181276.3:1..867" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0017196 N-terminal peptidyl-methionine acetylation [PMID:8175741]" /note="hypothetical protein; has an apparent role in acetylation of N-terminal methionine residues" /db_xref="GeneID:853050" /db_xref="SGD:S000003379" ORIGIN 1 mmvprisasp vfkriflrwg fvtlpiqktv shtlrrdfsa pcrsmvkcll lrpgisvhsa 61 qdrkfystee kssqfdenks ksnngkknep hgikglmaky gysalivyil ltcvdlplcf 121 lgvhslgeek ikiylnrgkq ligmgepdes kviqdvrrkq ahreavqaen adkvedasrk 181 tfnerwqemk dstllaelli aygihkslii vrvpltavlt psfvkllqrf gidlmkkqkk 241 vfqtmasgak irykgnnpsd fiknegtald itkrkprtkg qkwfdglm // LOCUS NP_011664 155 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL24 RPL24B [Saccharomyces cerevisiae S288C]. ACCESSION NP_011664 VERSION NP_011664.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181277.3 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08240. On Jul 30, 2012 this sequence version replaced NP_011664.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..155 /product="60S ribosomal protein eL24 RPL24B" /calculated_mol_wt="17416" Region 2..64 /region_name="Ribosomal_L24e" /note="Ribosomal protein L24e; pfam01246" /db_xref="CDD:460131" CDS 1..155 /gene="RPL24B" /locus_tag="YGR148C" /gene_synonym="RPL30B" /coded_by="NM_001181277.3:1..468" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:30407570]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:30407570]" /note="Ribosomal 60S subunit protein L24B; forms two bridges within ribosome, stimulates translation initiation and elongation; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication" /db_xref="GeneID:853051" /db_xref="SGD:S000003380" ORIGIN 1 mkvevdsfsg akiypgrgtl fvrgdskifr fqnsksaslf kqrknprria wtvlfrkhhk 61 kgiteevakk rsrktvkaqr pitgasldli kerrslkpev rkanreeklk ankekkraek 121 aarkaekaks agvqgskvsk qqakgafqkv aatsr // LOCUS NP_011665 432 aa linear PLN 30-JUN-2025 DEFINITION glycerophosphocholine acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011665 VERSION NP_011665.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181278.1 REFERENCE 1 (residues 1 to 432) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 432) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 432) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 432) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08241. Method: conceptual translation. FEATURES Location/Qualifiers source 1..432 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..432 /product="glycerophosphocholine acyltransferase" /calculated_mol_wt="51516" Region 115..221 /region_name="DUF2838" /note="Protein of unknown function (DUF2838); pfam10998" /db_xref="CDD:463204" CDS 1..432 /gene="GPC1" /locus_tag="YGR149W" /coded_by="NM_001181278.1:1..1299" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:27758859]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0106158 glycero-3-phosphocholine acyltransferase activity [PMID:27758859]" /experiment="EXISTENCE:genetic interaction:GO:0090640 phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine [PMID:30514764]" /experiment="EXISTENCE:mutant phenotype:GO:0036151 phosphatidylcholine acyl-chain remodeling [PMID:30514764]" /note="Glycerophosphocholine acyltransferase (GPCAT); involved in in phosphatidylcholine (PC) synthesis; uses acyl-CoA to acylate glycero-3-phosphocholine to yield lyso-PC; also catalyzes acylation of glycerophosphoethanolamine with acyl-CoA; predicted to be an integral membrane protein" /db_xref="GeneID:853052" /db_xref="SGD:S000003381" ORIGIN 1 mykldnndid detnnsvslt sllefldpia skvvskyyhg shlskaeqkl rnfegfrrrk 61 phhehdshhp hhlnrsrsfl qledfkvral qrirnldkpl dsiffknssr lekafypftl 121 fniffigflm grfpewfhvy ytilffvlmp irfytyyktk nhyfladfcy fvnmlcllfi 181 wifpysyslf qscfaftfgt lcfavitwrn slvihsidkt tscfihiipp cvmyviyhgl 241 pleykierfp gaiiqseldi kknilwtsly ylvwqslyhy fitlkksski ksgermtsfe 301 yltthqfknf wavklrspwp miiytlsqyf yqlftmllcg iwiryklaaa lfltivflwa 361 shngatyyid hygknfekev drlrlevenl qqklqpdsda visdasvndk dylnvnrded 421 fddsssvssk sd // LOCUS NP_011666 864 aa linear PLN 30-JUN-2025 DEFINITION Ccm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011666 VERSION NP_011666.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181279.1 REFERENCE 1 (residues 1 to 864) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 864) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 864) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 864) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 864) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 864) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 864) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 864) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08242. Method: conceptual translation. FEATURES Location/Qualifiers source 1..864 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..864 /product="Ccm1p" /calculated_mol_wt="101292" Region 324..365 /region_name="PPR_2" /note="PPR repeat family; pfam13041" /db_xref="CDD:463778" Region 324..349 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 355..398 /region_name="PPR_2" /note="PPR repeat family; pfam13041" /db_xref="CDD:463778" Region 357..386 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" CDS 1..864 /gene="CCM1" /locus_tag="YGR150C" /gene_synonym="DMR1; RRG2" /coded_by="NM_001181279.1:1..2595" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:20124025|PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:20124025]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:19751518]" /experiment="EXISTENCE:mutant phenotype:GO:0000963 mitochondrial RNA processing [PMID:19562342]" /experiment="EXISTENCE:mutant phenotype:GO:0008380 RNA splicing [PMID:19562342]" /experiment="EXISTENCE:mutant phenotype:GO:0016072 rRNA metabolic process [PMID:20124025]" /experiment="EXISTENCE:mutant phenotype:GO:2000234 positive regulation of rRNA processing [PMID:32152734]" /note="Mitochondrial 15S rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; has separable roles in stabilizing mitochondrial 15S rRNA and in maturation of the COB and COX1 mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport" /db_xref="GeneID:853053" /db_xref="SGD:S000003382" ORIGIN 1 mymarcgpkn nvlcfpfqls flfskrlink rfkytlqted eknmmgslsk nkiitpedve 61 fklaqlrefs ntlkerihnt ksvnsdghqs nsiapiseds rnvnvtktss vpneeksknl 121 sdlihssfle kmdhlvpkvi rervadddil aknlfdrshs nwapvidrly vsekrfmdid 181 srefsvwlng tvkylpfhsi lhldemlleq ingdvvkfnt hmyecifnnl gnlkptnfnq 241 dgtndkvilk mkellerydk alkiteerin kkegfpskvp kmtqailnnc lkystkcssf 301 hdmdyfitkf rddygitpnk qnlttviqfy srkemtkqaw ntfdtmkfls tkhfpdicty 361 ntmlriceke rnfpkaldlf qeiqdhnikp ttntyimmar vlassssnav vsegksdslr 421 llgwkylhel edknlyrhkk ddlnlflamm alaafdgdie lsralyylfi akkyktlcan 481 wkgnilvdqd tiwkstlmpe mlnylmlaya rfdprnlpvl sgyekgielr rkflrefdss 541 mrlddtdklv kfklpflpis dlnseaqvla esnaiwsfnm enggtrntlt ssneaaledi 601 kkyrqlldsf aqeaedfnef kfkvmyevtk mqresinvnv fnkislhtyl sipinlkqqk 661 eflrrltfft fqqhefeavi krlyegyrni psshtrdqns isteaisvsk pettedlnli 721 mhdiwyitcl rhkimmdttl yelvmkaaie fqnedlakkv wndrgkfrtt vpflkmdqri 781 riakdqkfah lmvefftkqg kysdaiaiil ssknrfnwty smvrnlhkal eeiedrnsve 841 illdvvnkks hakalkweeq elnm // LOCUS NP_011668 272 aa linear PLN 30-JUN-2025 DEFINITION Ras family GTPase RSR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011668 VERSION NP_011668.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181281.3 REFERENCE 1 (residues 1 to 272) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 272) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 272) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 272) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08243. On Jul 30, 2012 this sequence version replaced NP_011668.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..272 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..272 /product="Ras family GTPase RSR1" /EC_number="3.6.5.2" /calculated_mol_wt="30260" Region 3..166 /region_name="RSR1" /note="RSR1/Bud1p family GTPase; cd04177" /db_xref="CDD:133377" Site 10..17 /site_type="other" /note="G1 box" /db_xref="CDD:133377" Site order(11..12,59..60) /site_type="other" /note="putative GDI interaction site [polypeptide binding]" /db_xref="CDD:133377" Site order(12..18,57,60,116..117,119,147..148) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:133377" Site order(17..18,32,34,40..41,54..55,57,59..60,149) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:133377" Site order(25,31,33,36..41) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:133377" Site 33..40 /site_type="other" /note="Switch I region" /db_xref="CDD:133377" Site 35 /site_type="other" /note="G2 box" /db_xref="CDD:133377" Site 57..60 /site_type="other" /note="G3 box" /db_xref="CDD:133377" Site order(59..65,68..73,76..77) /site_type="other" /note="Switch II region" /db_xref="CDD:133377" Site 116..119 /site_type="other" /note="G4 box" /db_xref="CDD:133377" Site 147..149 /site_type="other" /note="G5 box" /db_xref="CDD:133377" CDS 1..272 /gene="RSR1" /locus_tag="YGR152C" /gene_synonym="BUD1" /coded_by="NM_001181281.3:1..819" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12058023]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:1910037]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:12058023]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12058023|PMID:8723349]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:12058023]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:12058023]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030427 site of polarized growth [PMID:14872283]" /experiment="EXISTENCE:genetic interaction:GO:0032507 maintenance of protein location in cell [PMID:14872283]" /experiment="EXISTENCE:mutant phenotype:GO:0000080 mitotic G1 phase [PMID:12058023]" /experiment="EXISTENCE:mutant phenotype:GO:0000131 incipient cellular bud site [PMID:12058023|PMID:14988726]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:9744878]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:20587777]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:2065354]" /experiment="EXISTENCE:mutant phenotype:GO:0007264 small GTPase-mediated signal transduction [PMID:1910037]" /experiment="EXISTENCE:mutant phenotype:GO:0035025 positive regulation of Rho protein signal transduction [PMID:14988726]" /experiment="EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:14988726|PMID:12058023]" /experiment="EXISTENCE:mutant phenotype:GO:2000114 regulation of establishment of cell polarity [PMID:31411940]" /note="Ras-type GTPase; required for bud site selection during both axial and bipolar budding, for morphological changes in response to mating pheromone, and for efficient cell fusion; recruits Cdc24p to the incipient bud site, activating its guanyl-nucleotide exchange factor activity and the Rho-like GTPase, Cdc42p; localizes to the plasma membrane, the incipient bud site, polarized growth sites, the cell division site and the vacuole membrane; Ras superfamily member similar to mammalian Rap GTPases" /db_xref="GeneID:853056" /db_xref="SGD:S000003384" ORIGIN 1 mrdyklvvlg aggvgksclt vqfvqgvyld tydptiedsy rktieidnkv fdleildtag 61 iaqftamrel yiksgmgfll vysvtdrqsl eelmelreqv lrikdsdrvp mvlignkadl 121 inervisvee gievsskwgr vpfyetsall rsnvdevfvd lvrqiirnem esvavkdarn 181 qsqqfskies pstrlpssak qdtkqsnnkq sskglynkss qgqakvkqst pvnekhkpsh 241 avpksgssnr tgisatsqqk kkkknastct il // LOCUS NP_011669 217 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR153W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011669 VERSION NP_011669.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181282.2 REFERENCE 1 (residues 1 to 217) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 217) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 217) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 217) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08244. On Apr 26, 2011 this sequence version replaced NP_011669.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..217 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..217 /product="uncharacterized protein" /calculated_mol_wt="25038" CDS 1..217 /locus_tag="YGR153W" /coded_by="NM_001181282.2:1..654" /note="hypothetical protein" /db_xref="GeneID:853057" /db_xref="SGD:S000003385" ORIGIN 1 mgkaclnkev gtyecegerd tysfftslsd iqdsssneeq cgvgsilsed sftfegsnvs 61 irlfsldlna lnenengskn pvkftippki eqrkearqre krlrrvavlp ensrnylves 121 smdssreysq pffdwrhemv ehgeesvkpc gchksrkakc fkelemenie kgdikkslfy 181 rdiiewcrdy evnktrevcv psihefylhg ngsdnlf // LOCUS NP_011670 356 aa linear PLN 30-JUN-2025 DEFINITION omega-class glutathione transferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011670 VERSION NP_011670.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181283.3 REFERENCE 1 (residues 1 to 356) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 356) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 356) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 356) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08245. On Jul 30, 2012 this sequence version replaced NP_011670.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..356 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..356 /product="omega-class glutathione transferase" /EC_number="1.8.5.1" /EC_number="2.5.1.18" /calculated_mol_wt="41170" Region 16..352 /region_name="ECM4" /note="Glutathionyl-hydroquinone reductase [Energy production and conversion]; COG0435" /db_xref="CDD:440204" CDS 1..356 /gene="GTO1" /locus_tag="YGR154C" /coded_by="NM_001181283.3:1..1071" /experiment="EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:16709151]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:16936141]" /note="Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization" /db_xref="GeneID:853058" /db_xref="SGD:S000003386" ORIGIN 1 msvsykgtis kthsvfkpek gryyiygalg cpfthraila rslkklepvl glvlshwqld 61 skgarflpap hrpekykerf ftatggiasa kldeseelgd vnndsarlfv dgafdpveni 121 srlselyyln dpkypgtkft vpvlwdsktr kivnnesgdi irilnsgvfd efiqseetnv 181 idlvphdlid eidknikwvh pkinlgvykv glaengkiye tevktlfenl qkmecvlken 241 ykrleeqfsg nkqkilakyf vlgqrltead irlypsiirf dvvyvqhfkc nlktirdgfp 301 ylhlwlinly wnyaefrftt dfnhiklfyi rmevsrnkin qfgivplgpk pdisrl // LOCUS NP_011671 507 aa linear PLN 30-JUN-2025 DEFINITION cystathionine beta-synthase CYS4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011671 VERSION NP_011671.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181284.3 REFERENCE 1 (residues 1 to 507) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 507) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 507) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 507) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08246. On Jul 30, 2012 this sequence version replaced NP_011671.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..507 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..507 /product="cystathionine beta-synthase CYS4" /EC_number="4.2.1.22" /calculated_mol_wt="55891" Region 10..507 /region_name="cysta_beta" /note="cystathionine beta-synthase; TIGR01137" /db_xref="CDD:273464" CDS 1..507 /gene="CYS4" /locus_tag="YGR155W" /gene_synonym="NHS5; STR4; VMA41" /coded_by="NM_001181284.3:1..1524" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004122 cystathionine beta-synthase activity [PMID:10766767|PMID:19264153|PMID:11948191]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640|PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006535 cysteine biosynthetic process from serine [PMID:11948191]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0070814 hydrogen sulfide biosynthetic process [PMID:19531479]" /experiment="EXISTENCE:mutant phenotype:GO:0004122 cystathionine beta-synthase activity [PMID:10509018|PMID:8366024]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:22438835]" /experiment="EXISTENCE:mutant phenotype:GO:0019343 cysteine biosynthetic process via cystathionine [PMID:10509018|PMID:8366024]" /experiment="EXISTENCE:mutant phenotype:GO:0019346 transsulfuration [PMID:8366024]" /note="Cystathionine beta-synthase; catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; advances passage through START by promoting cell growth which requires catalytic activity, and reducing critical cell size independent of catalytic activity; mutations in human ortholog CBS cause homocystinuria; human CBS can complement yeast null mutant" /db_xref="GeneID:853059" /db_xref="SGD:S000003387" ORIGIN 1 mtkseqqads rhnvidlvgn tplialkklp kalgikpqiy aklelynpgg sikdriaksm 61 veeaeasgri hpsrstliep tsgntgigla ligaikgyrt iitlpekmsn ekvsvlkalg 121 aeiirtptaa awdspeshig vakklekeip gavildqynn mmnpeahyfg tgreiqrqle 181 dlnlfdnlra vvagagtggt isgiskylke qndkiqivga dpfgsilaqp enlnktditd 241 ykvegigydf vpqvldrkli dvwyktddkp sfkyarqlis negvlvggss gsaftavvky 301 cedhpelted dvivaifpds irsyltkfvd dewlkknnlw dddvlarfds skleasttky 361 advfgnatvk dlhlkpvvsv ketakvtdvi kilkdngfdq lpvltedgkl sglvtlsell 421 rklsinnsnn dntikgkyld fkklnnfndv ssynenksgk kkfikfdens klsdlnrffe 481 knssavitdg lkpihivtkm dllsyla // LOCUS NP_011672 425 aa linear PLN 30-JUN-2025 DEFINITION cleavage polyadenylation factor subunit PTI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011672 VERSION NP_011672.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181285.1 REFERENCE 1 (residues 1 to 425) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 425) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 425) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 425) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08247. Method: conceptual translation. FEATURES Location/Qualifiers source 1..425 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..425 /product="cleavage polyadenylation factor subunit PTI1" /calculated_mol_wt="46853" Region 21..90 /region_name="RRM" /note="RNA recognition motif; smart00360" /db_xref="CDD:214636" Region 185..255 /region_name="CSTF2_hinge" /note="Hinge domain of cleavage stimulation factor subunit 2; pfam14327" /db_xref="CDD:433869" Region <306..413 /region_name="PABP-1234" /note="polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628" /db_xref="CDD:130689" CDS 1..425 /gene="PTI1" /locus_tag="YGR156W" /coded_by="NM_001181285.1:1..1278" /experiment="EXISTENCE:curator inference:GO:0003723 RNA binding [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:24390141|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:12504017]" /experiment="EXISTENCE:mutant phenotype:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:12773397]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:12773397]" /note="Essential component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; relocalizes to the cytosol in response to hypoxia; similar to mammalian Cleavage-Stimulation Factor CstF-64" /db_xref="GeneID:853060" /db_xref="SGD:S000003388" ORIGIN 1 mtdprrrtgr hfltpenlss tlqitnlppe wnqdiitsvv agsgpvidik akndprtgkl 61 tgvlfdylts kdckraweil nrienfpvki eqiippnykd hlretankns qkqvlqlnrd 121 sypfeaglel pfemvtevpi prrppppqaa nntnsvsnnt niqfpdilsk askhlpsfqd 181 gsiiapdkis qnlskipplq lieiisnlki lsnqeniqks qlesfldtns ditisvtqal 241 lemgfidysv vtkvlksqvg eapsllssnn tsnsntpvsv irnntplhvp snevsnnpnn 301 mplnvampmp mstppfiplp lqqqpfgfap pgpfmppaqg psmgqpvlan qlgqvqqqni 361 sstegpsnan kandsgtinm aklqllpenq qdmikqvltl tpaqiqslps dqqlmvenfr 421 keyii // LOCUS NP_011673 869 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylethanolamine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011673 VERSION NP_011673.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181286.1 REFERENCE 1 (residues 1 to 869) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 869) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 869) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 869) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08248. Method: conceptual translation. FEATURES Location/Qualifiers source 1..869 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..869 /product="phosphatidylethanolamine N-methyltransferase" /EC_number="2.1.1.17" /calculated_mol_wt="101073" Region 218..321 /region_name="PEMT" /note="Phospholipid methyltransferase; pfam04191" /db_xref="CDD:461218" Region 471..577 /region_name="PEMT" /note="Phospholipid methyltransferase; pfam04191" /db_xref="CDD:461218" CDS 1..869 /gene="CHO2" /locus_tag="YGR157W" /gene_synonym="PEM1" /coded_by="NM_001181286.1:1..2610" /experiment="EXISTENCE:direct assay:GO:0004608 phosphatidylethanolamine N-methyltransferase activity [PMID:2445736|PMID:3066687]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:2445736|PMID:3066687]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0004608 phosphatidylethanolamine N-methyltransferase activity [PMID:2445736]" /experiment="EXISTENCE:genetic interaction:GO:0006656 phosphatidylcholine biosynthetic process [PMID:2445736]" /experiment="EXISTENCE:mutant phenotype:GO:0004608 phosphatidylethanolamine N-methyltransferase activity [PMID:3066687]" /experiment="EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:3066687|PMID:23000174]" /note="Phosphatidylethanolamine methyltransferase (PEMT); catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis" /db_xref="GeneID:853061" /db_xref="SGD:S000003389" ORIGIN 1 mssckttlse mvgsvtkdrg tinveartrs snvtfkppvt hdmvrslfdp tlkksllekc 61 ialaiisnff icywvfqrfg lqftkyfflv qylfwriayn lgiglvlhyq shyetltnca 121 kthaifskip qnkdansnfs tnsnsfsekf wnfirkfcqy eirskmpkey dlfaypeein 181 vwlifrqfvd lilmqdfvty iiyvylsipy swvqifnwrs llgvililfn iwvkldahrv 241 vkdyawywgd fffleeseli fdgvfnisph pmysigylgy yglslicndy kvllvsvfgh 301 ysqflflkyv enphiertyg dgtdsdsqmn sriddliske nydysrplin mglsfnnfnk 361 lrftdyftig tvaalmlgti mnarfinlny lfitvfvtkl vswlfistil ykqsqskwft 421 rlflengytq vysyeqwqfi ynyylvltyt lmiihtglqi wsnfsninns qlifglilva 481 lqtwcdketr laisdfgwfy gdfflsnyis trkltsqgiy rylnhpeavl gvvgvwgtvl 541 mtnfavtnii lavlwtltnf ilvkfietph vnkiygktkr vsgvgktllg lkplrqvsdi 601 vnrieniiik slvdesknsn ggaellpkny qdnkewnili qeamdsvatr lspycelkie 661 neqvetnfvl ptpvtlnwkm pielyngddw iglykvidtr adrektrvgs gghwsatskd 721 symnhglrhk esvteikate kyvqgkvtfd tsllyfengi yefryhsgns hkvllistpf 781 eislpvlntt tpelfekdlt efltkvnvlk dgkfrplgnk ffgmdslkql iknsigvels 841 seymrrvngd ahvishrawd ikqtldsla // LOCUS NP_011674 250 aa linear PLN 30-JUN-2025 DEFINITION exosome non-catalytic core subunit MTR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011674 VERSION NP_011674.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181287.3 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08249. On Jul 30, 2012 this sequence version replaced NP_011674.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..250 /product="exosome non-catalytic core subunit MTR3" /calculated_mol_wt="27446" Region 48..247 /region_name="RNase_PH" /note="RNase PH-like 3'-5' exoribonucleases; cl03114" /db_xref="CDD:446015" Site order(55,57,76,78..80,94,96,112,115,119,133,138,152, 181..183,190,209..216,217..220,223,227) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:206766" Site order(92..94,115,122) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:206766" CDS 1..250 /gene="MTR3" /locus_tag="YGR158C" /coded_by="NM_001181287.3:1..753" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:19046973|PMID:10465791]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:8534909]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15935758|PMID:17643380|PMID:15828860]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10508172|PMID:10465791]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10611222]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:11030620]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:18007593|PMID:10465791]" /experiment="EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]" /experiment="EXISTENCE:mutant phenotype:GO:0071051 poly(A)-dependent snoRNA 3'-end processing [PMID:10611222]" /note="Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)" /db_xref="GeneID:853062" /db_xref="SGD:S000003390" ORIGIN 1 mnvqdrrrll gpaaakpmaf snttthvpek kstdltpkgn eseqelslht gfiencngsa 61 lvearslghq tslitavygp rsirgsftsq gtisiqlkng llekyntnel kevssflmgi 121 fnsvvnlsry pksgidifvy ltydkdltnn pqdddsqskm mssqisslip hcitsitlal 181 adagielvdm agageangtv vsfikngeei vgfwkddgdd edllecldrc keqynryrdl 241 misclmnqet // LOCUS NP_011675 414 aa linear PLN 30-JUN-2025 DEFINITION Nsr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011675 VERSION NP_011675.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181288.1 REFERENCE 1 (residues 1 to 414) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 414) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 414) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 414) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08250. Method: conceptual translation. FEATURES Location/Qualifiers source 1..414 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..414 /product="Nsr1p" /calculated_mol_wt="44404" Region 169..244 /region_name="RRM1_gar2" /note="RNA recognition motif 1 (RRM1) found in yeast protein gar2 and similar proteins; cd12447" /db_xref="CDD:409881" Region 269..341 /region_name="RRM2_gar2" /note="RNA recognition motif 2 (RRM2) found in yeast protein gar2 and similar proteins; cd12448" /db_xref="CDD:409882" CDS 1..414 /gene="NSR1" /locus_tag="YGR159C" /gene_synonym="SHE5" /coded_by="NM_001181288.1:1..1245" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:19861225]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:1706724]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:1706724]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:1706724]" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:7800479]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:33106247]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:33106247]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:33106247]" /experiment="EXISTENCE:mutant phenotype:GO:0051880 G-quadruplex DNA binding [PMID:33106247]" /note="Nucleolin, nucleolar protein that binds nuclear localization sequences; required for pre-rRNA processing and ribosome biogenesis; binds to single stranded telomeric DNA and mRNA; binds to G-quadruplex DNA; methylated by Hmt1p; interaction with Top1p and nucleolar localization are negatively regulated by lysine polyphosphorylation" /db_xref="GeneID:853064" /db_xref="SGD:S000003391" ORIGIN 1 makttkvkgn kkevkaskqa keekakavss sssessssss sssesesese sesessssss 61 ssdsesssss ssdseseaet kkeeskdsss sssdsssdee eeeekeetkk eeskessssd 121 sssssssdse sekeesndkk rksedaeeee deessnkkqk neeteepati fvgrlswsid 181 dewlkkefeh iggvigarvi yergtdrsrg ygyvdfenks yaekaiqemq gkeidgrpin 241 cdmstskpag nndrakkfgd tpsepsdtlf lgnlsfnadr daifelfakh gevvsvript 301 hpeteqpkgf gyvqfsnmed akkaldalqg eyidnrpvrl dfssprpnnd ggrggsrgfg 361 grgggrggnr gfggrggarg grggfrpsgs gantaplgrs rntasfagsk ktfd // LOCUS NP_011677 263 aa linear PLN 30-JUN-2025 DEFINITION Rts3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011677 VERSION NP_011677.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181290.3 REFERENCE 1 (residues 1 to 263) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 263) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 263) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 263) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08251. On Jul 30, 2012 this sequence version replaced NP_011677.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..263 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..263 /product="Rts3p" /calculated_mol_wt="29132" CDS 1..263 /gene="RTS3" /locus_tag="YGR161C" /coded_by="NM_001181290.3:1..792" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative component of the protein phosphatase type 2A complex" /db_xref="GeneID:853065" /db_xref="SGD:S000003393" ORIGIN 1 miatsravnm nkeskhkkav akpcrerqts vtramrpava rdprrlstss spssspmsaq 61 rrlsreeiin emekeqdaiv vrllreietl keensrlknq lhhpvparrs spffegesai 121 lddddcnygy tldtpklklt dgasrhtvlp ltpkdsmthi shsarrssrn asisngtsis 181 dtifpietki hsapttnrnl psadlphhtl lprslsgiss sdltesgall hdrrrrssny 241 sldgsnslka dlmakrfqtg slk // LOCUS NP_001018033 92 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR161W-C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001018033 VERSION NP_001018033.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184675.3 REFERENCE 1 (residues 1 to 92) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 92) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 92) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 92) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08252. On Jul 30, 2012 this sequence version replaced NP_001018033.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..92 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..92 /product="uncharacterized protein" /calculated_mol_wt="9896" CDS 1..92 /locus_tag="YGR161W-C" /coded_by="NM_001184675.3:1..279" /note="hypothetical protein; identified by sequence comparison with hemiascomycetous yeast species" /db_xref="GeneID:3077355" /db_xref="SGD:S000029726" ORIGIN 1 msgyfnhlss nahfaniqad qgfigdatgt ssdhgssgmv dfalqlgels leekilkeft 61 lfqsknmdll qetatacpst npslrqsriq gw // LOCUS NP_058164 438 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058164 VERSION NP_058164.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184401.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08254. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..438 /product="gag protein" /calculated_mol_wt="49631" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..438 /locus_tag="YGR161W-A" /coded_by="NM_001184401.1:1..1317" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:853066" /db_xref="SGD:S000007369" ORIGIN 1 mesqqlhqnp hslhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqnq hsevpqaetk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeiksqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lrpateri // LOCUS NP_058163 1770 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058163 VERSION NP_058163.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184402.2 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08253. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1770 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="201909" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 574..641 /region_name="gag_pre-integrs" /note="GAG-pre-integrase domain; pfam13976" /db_xref="CDD:372857" Region 660..761 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1285..>1468 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1621..1757 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1625..1628,1662..1664,1667,1700,1727,1754) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1770 /locus_tag="YGR161W-B" /coded_by="join(NM_001184402.2:1..1293, NM_001184402.2:1295..5314)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:853067" /db_xref="SGD:S000007370" ORIGIN 1 mesqqlhqnp hslhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqnq hsevpqaetk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeiksqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lgqqqkeskp thtidsndel pdhllidsga sqtlvrsahy lhhatpnsei 481 nivdaqkqdi pinaignlhf nfqngtktsi kalhtpniay dllslselan qnitacftrn 541 tlersdgtvl apivkhgdfy wlskkylips hiskltinnv nksksvnkyp yplihrmlgh 601 anfrsiqksl kknavtylke sdiewsnast yqcpdcligk stkhrhvkgs rlkyqesyep 661 fqylhtdifg pvhhlpksap syfisftdek trfqwvyplh drreesilnv ftsilafikn 721 qfnarvlviq mdrgseytnk tlhkfftnrg itacytttad srahgvaerl nrtllndcrt 781 llhcsglpnh lwfsavefst iirnslvspk ndksarqhag lagldittil pfgqpvivnn 841 hnpdskihpr gipgyalhps rnsygyiiyl pslkktvdtt nyvilqdkqs kldqfnydtl 901 tfdddlnrlt ahnqsfieqn eteqsydqnt esdhdyqsei einsdplvnd fssqsinplq 961 ldkepvqkvr apkevdadis eynilpstir srtphiinke stemggtves dttsprhsst 1021 ftarnqnrpg stnemidlts qdrvnyglen ikttrlggte epyiqrnsdt nikyrttnst 1081 psiddrssns esttpiisie tkavcdntps idtdppeyrs sdhatpnimp dkssknvtad 1141 silddlplpd lthksptdts dvskdiphih srqtnsslgg mddsnvlttt kskkrsledn 1201 eteievsrdt wnnknmrsle pprskkrinl iaaikgvksi kpvrttlryd eaitynkdnk 1261 ekdryveayh keisqllkmn twdtnkyydr ndidpkkvin smfifnkkrd gthkarfvar 1321 gdiqhpdtyd sdmqsntvhh yalmtslsia ldndyyitql dissaylyad ikeelyirpp 1381 phlglndkll rlrkslyglk qsganwyeti ksylinccdm qevrgwscvf knsqvticlf 1441 vddmilfskd lnankkiitt lkkqydtkii nlgesdneiq ydilgleiky qrskymklgm 1501 ekslteklpk lnvplnpkgk klrapgqpgh yidqdeleid edeykekvhe mqkliglasy 1561 vgykfrfdll yyintlaqhi lfpsrqvldm tyeliqfmwd trdkqliwhk nkptkpdnkl 1621 vaisdasygn qpyyksqign ifllngkvig gkstkasltc tstteaeiha vseaipllnn 1681 lshlvqelnk kpiikglltd srstisiiks tneekfrnrf fgtkamrlrd evsgnnlyvy 1741 yietkkniad vmtkplpikt fklltnkwih // LOCUS NP_058165 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058165 VERSION NP_058165.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184400.4 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08255. On Jul 30, 2012 this sequence version replaced NP_058165.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198429" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YGR161C-D" /coded_by="join(NM_001184400.4:1..1305, NM_001184400.4:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:853068" /db_xref="SGD:S000007368" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess yaskskdfrh sdsysdnetn htnvpisstg gtnnktvpqt 1081 seqetekrii hrspsidtss sesnslhhvv piktsdtcpk enteesiiad lplpdlppep 1141 ptelsdsfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmntwdtd kyydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnsnk 1441 riiaklkmqy dtkiinlges ddeiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npngrklgap gqpglyinqq eleleeddyk mkvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsk qvldmtyeli qfiwntrdkq liwhkskpvk ptnklvvisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qeldkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_058166 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058166 VERSION NP_058166.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184399.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08256. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..440 /product="gag protein" /calculated_mol_wt="48998" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YGR161C-C" /coded_by="NM_001184399.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:853069" /db_xref="SGD:S000007367" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_011678 952 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF4G [Saccharomyces cerevisiae S288C]. ACCESSION NP_011678 VERSION NP_011678.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181291.3 REFERENCE 1 (residues 1 to 952) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 952) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 952) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 952) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 952) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 952) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 952) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 952) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08257. On Jul 30, 2012 this sequence version replaced NP_011678.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..952 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..952 /product="translation initiation factor eIF4G" /calculated_mol_wt="106971" Region <133..362 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" Region 411..469 /region_name="eIF_4G1" /note="Eukaryotic translation initiation factor 4G1; pfam12152" /db_xref="CDD:432365" Region 489..>562 /region_name="SF-CC1" /note="splicing factor, CC1-like family; TIGR01622" /db_xref="CDD:273721" Region 607..850 /region_name="MIF4G" /note="MIF4G domain; pfam02854" /db_xref="CDD:397130" CDS 1..952 /gene="TIF4631" /locus_tag="YGR162W" /coded_by="NM_001181291.3:1..2859" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:24080224|PMID:21062831|PMID:18606994]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:12810920]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21925384]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:17908917|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:1901195 positive regulation of formation of translation preinitiation complex [PMID:30281017]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:12810920]" /experiment="EXISTENCE:mutant phenotype:GO:0016281 eukaryotic translation initiation factor 4F complex [PMID:8336723]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:19806183]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:21925384]" /note="Translation initiation factor eIF4G and scaffold protein; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E (Cdc33p) and eIF4A (Tif1p/Tif2p); stimulates the ATPase and helicase activities of eIF4A synergistically with eIF4G; required with eIF4E for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; association with Pab1p mediates poly(A) tail-stimulated translation; role in assembly of PET region in biogenesis of 60S ribosomal subunit" /db_xref="GeneID:853071" /db_xref="SGD:S000003394" ORIGIN 1 mtdetahptq saskqesaal kqtgddqqes qqqrgytnyn ngsnytqkkp ynsnrphqqr 61 ggkfgpnryn nrgnyngggs frgghmgans snvpwtgyyn nypvyyqpqq maaagsapan 121 pipveekspv ptkieittks gehldlkeqh kaklqsqers tvspqpeskl ketsdststs 181 tptptpstnd skasseenis eaektrrnfi eqvklrkaal ekkrkeqleg ssgnnnipmk 241 ttpenveekg sdkpevtekt kpaeeksaep evkqetpaee geqgekgqik eestpkvltf 301 aerlklkkqq kereektegk enkevpvqee tksaiesapv ppseqvkeet evaeteqsni 361 desattpaip tksdeaeaev eaeagdagtk igleaeiett tdetddgtnt vshilnvlkd 421 atpiedvfsf nypegiegpd ikykkehvky tygptfllqf kdklnvkada ewvqstaski 481 vippgmgrgn rsrdsgrfgn nssrghdfrn tsvrnmddra nsrtsskrrs krmnddrrsn 541 rsytsrrdre rgsyrneekr eddkpkeeva plvpsanrwv pkfkskktek klapdgktel 601 ldkdeverkm ksllnkltle mfdaisseil aianisvwet ngetlkavie qiflkacdep 661 hwssmyaqlc gkvvkelnpd itdetnegkt gpklvlhylv archaefdkg wtdklptned 721 gtplepemms eeyyaaasak rrglglvrfi gflyrlnllt gkmmfecfrr lmkdltdsps 781 eetlesvvel lntvgeqfet dsfrtgqatl egsqlldslf gildniiqta kissrikfkl 841 idikelrhdk nwnsdkkdng pktiqqihee eerqrqlknn srsnsrrtnn ssnrhsfrrd 901 appaskdsfi ttrtysqrns qrapppkeep aaptstatnm fsalmgesdd ee // LOCUS NP_011679 341 aa linear PLN 30-JUN-2025 DEFINITION Gtr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011679 VERSION NP_011679.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181292.3 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08258. On Jul 30, 2012 this sequence version replaced NP_011679.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..341 /product="Gtr2p" /calculated_mol_wt="38469" Region 12..235 /region_name="Gtr1_RagA" /note="Gtr1/RagA G protein conserved region; pfam04670" /db_xref="CDD:398377" Site 16..23 /site_type="other" /note="G1 box" /db_xref="CDD:206745" Site order(21..24,65,124..125,127,165..167) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206745" Site 44 /site_type="other" /note="G2 box" /db_xref="CDD:206745" Site 48..50 /site_type="other" /note="Switch I region" /db_xref="CDD:206745" Site 62..65 /site_type="other" /note="G3 box" /db_xref="CDD:206745" Site order(64..65,84..85) /site_type="other" /note="Switch II region" /db_xref="CDD:206745" Site 124..127 /site_type="other" /note="G4 box" /db_xref="CDD:206745" Site 165..167 /site_type="other" /note="G5 box" /db_xref="CDD:206745" CDS 1..341 /gene="GTR2" /locus_tag="YGR163W" /coded_by="NM_001181292.3:1..1026" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:15989961|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:18258182]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:26387955]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:16143306]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10388807|PMID:11073942]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11073942|PMID:10388807]" /experiment="EXISTENCE:direct assay:GO:0031902 late endosome membrane [PMID:16732272]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:18258182]" /experiment="EXISTENCE:direct assay:GO:0071986 Ragulator complex [PMID:16732272]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:25046117]" /experiment="EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:25046117]" /experiment="EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:15989961]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:35158208]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:26387955]" /experiment="EXISTENCE:mutant phenotype:GO:1903778 protein localization to vacuolar membrane [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353|PMID:26387955]" /experiment="EXISTENCE:physical interaction:GO:0071986 Ragulator complex [PMID:15989961]" /experiment="EXISTENCE:physical interaction:GO:1990131 Gtr1-Gtr2 GTPase complex [PMID:16143306|PMID:10388807]" /note="Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex; subunit of Gtr1-Gtr2, a GTPase that activates TORC1 in response to amino acid stimulation; negatively regulates the GTPase cycle of Gtr1p, a Ran/TC4 homolog; subunit of EGO, a vacuolar membrane complex that regulates exit from rapamycin-induced growth arrest and esorting of Gap1p; activates transcription when chromatin bound; role in the oxidative stress response; activated by the Lst4p-Lst7p GAP complex; homolog of human RagC" /db_xref="GeneID:853072" /db_xref="SGD:S000003395" ORIGIN 1 msleatdska mvllmgvrrc gkssickvvf hnmqpldtly lestsnpsle hfstlidlav 61 melpgqlnyf epsydserlf ksvgalvyvi dsqdeyinai tnlamiieya ykvnpsinie 121 vlihkvdgls edfkvdaqrd imqrtgeell elgldgvqvs fyltsifdhs iyeafsrivq 181 klipelsfle nmldnliqhs kiekaflfdv nskiyvstds npvdiqmyev csefidvtid 241 lfdlykapvl rnsqkssdkd nvinprnelq nvsqlangvi iylrqmirgl alvaiirpng 301 tdmescltva dynidifkkg lediwanara sqaknsiedd v // LOCUS NP_001335783 111 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR164W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335783 VERSION NP_001335783.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348843.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80303. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..111 /product="uncharacterized protein" /calculated_mol_wt="13062" CDS 1..111 /locus_tag="YGR164W" /coded_by="NM_001348843.1:1..336" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:853073" /db_xref="SGD:S000003396" ORIGIN 1 mivepmtkpr kptvqrcqsf ftnganhfyc kksthdggrt hnllirsqtr chyatratvc 61 wkfsiinkyi ptlanititt lrklykrfid reslfliffr kdehivqnii n // LOCUS NP_011681 345 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS45 MRPS35 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011681 VERSION NP_011681.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181294.1 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08259. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..345 /product="mitochondrial 37S ribosomal protein mS45 MRPS35" /calculated_mol_wt="39444" Region 133..303 /region_name="Bot1p" /note="Eukaryotic mitochondrial regulator protein; pfam12298" /db_xref="CDD:403498" CDS 1..345 /gene="MRPS35" /locus_tag="YGR165W" /gene_synonym="mS45" /coded_by="NM_001181294.1:1..1038" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets" /db_xref="GeneID:853075" /db_xref="SGD:S000003397" ORIGIN 1 msygltgtss klrgtssifs wtqvrhfsrr riaypfypfk klgrqhpkkh dtnlktamrq 61 flgpknykge yvmnkyftvp tnhvpnyikp dlergqsleh pvtkkplqlr ydgtlgpppv 121 enkrlqnifk drllqpfpsn phcktnyvls pqlkqsifee itveglsaqq vsqkyglkip 181 rveaivklvs venswnrrnr vssdlktmde tlyrmfpvfd sdasfkrenl seipvpqktl 241 asrfltiaes epfgpvdaah vlelepavet lrnlstvgeh ssghqqstnk ntkviygelv 301 egersqykft nakvgkvgyr ygsgnrdnkk drrigfnklg qmvyi // LOCUS NP_011682 560 aa linear PLN 30-JUN-2025 DEFINITION Trs65p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011682 VERSION NP_011682.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181295.1 REFERENCE 1 (residues 1 to 560) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 560) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 560) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 560) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08260. Method: conceptual translation. FEATURES Location/Qualifiers source 1..560 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..560 /product="Trs65p" /calculated_mol_wt="63237" Region 257..559 /region_name="Trs65" /note="TRAPP trafficking subunit Trs65; pfam12735" /db_xref="CDD:463685" CDS 1..560 /gene="TRS65" /locus_tag="YGR166W" /gene_synonym="KRE11" /coded_by="NM_001181295.1:1..1683" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:17475775]" /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]" /experiment="EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17475775]" /experiment="EXISTENCE:genetic interaction:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:17475775]" /experiment="EXISTENCE:genetic interaction:GO:0065003 protein-containing complex assembly [PMID:17475775]" /experiment="EXISTENCE:physical interaction:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:17475775]" /note="Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic; role in cell wall beta-glucan biosynthesis and the stress response" /db_xref="GeneID:853076" /db_xref="SGD:S000003398" ORIGIN 1 mecfvplrcd ldgsnieqlr qshlsrkfii fdeqlnlwlw fqgnsqenkr fvlqnmiili 61 neaqvtrtst iddyftqven nenlwrlknd ccskilfksn vvmnngynnq ikfvfeyksv 121 danfnnqdsl qdpqakytld kysseeilps fepvyswssa atksskntnn hleknnrath 181 rvssknsevh eadvsrnpnt ftlklqypif sllnmrlrni slksehcils sldfqtskas 241 eqltkkfiyp qehnsflkln fqeisyklid gtsqieldpi cplkvpltaf sydsisatfk 301 lvllpkstqp hrvkitlaye lelhpnlklp vrtswetevt lkrsmpisst ssqyssnnnn 361 tnhsasfnga annvnsggla nlrlggvsss rfslgaastt slvnsklsnv kfkfinsnik 421 vikgekftmr lqiinssssp ldlvvyynnt inpipsannv rnsnginncg mnngtipnsp 481 ltlenqyqlh nkyrkiaegi illsndykip vvppretyfa dlrfigimsg yygtlsglkv 541 ldlntnelie vgngasvliq // LOCUS NP_011683 233 aa linear PLN 30-JUN-2025 DEFINITION clathrin light chain CLC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011683 VERSION NP_011683.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181296.3 REFERENCE 1 (residues 1 to 233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 233) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08261. On Jul 30, 2012 this sequence version replaced NP_011683.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..233 /product="clathrin light chain CLC1" /calculated_mol_wt="26400" Region 5..233 /region_name="Clathrin_lg_ch" /note="Clathrin light chain; pfam01086" /db_xref="CDD:460056" CDS 1..233 /gene="CLC1" /locus_tag="YGR167W" /gene_synonym="SCD4" /coded_by="NM_001181296.3:1..702" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:27062026]" /experiment="EXISTENCE:direct assay:GO:0006897 endocytosis [PMID:16643280]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:16643280]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:21849475]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:27062026]" /experiment="EXISTENCE:physical interaction:GO:0006897 endocytosis [PMID:16643280]" /note="Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; regulates endocytic progression; thought to regulate clathrin function; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion" /db_xref="GeneID:853077" /db_xref="SGD:S000003399" ORIGIN 1 msekfppled qnidftpndk kdddtdflkr eaeilgdefk teqddilete aspakdddei 61 rdfeeqfpdi nsangavssd qngsatvssg ndngeadddf stfeganqst esvkedrsev 121 vdqwkqrrav eihekdlkde elkkelqdea ikhiddfyds ynkkkeqqle daakeaeafl 181 kkrdeffgqd nttwdralql inqddadiig grdrsklkei llrlkgnaka pga // LOCUS NP_011684 376 aa linear PLN 30-JUN-2025 DEFINITION Pex35p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011684 VERSION NP_011684.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181297.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08262. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..376 /product="Pex35p" /calculated_mol_wt="44170" CDS 1..376 /gene="PEX35" /locus_tag="YGR168C" /coded_by="NM_001181297.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:28049721]" /experiment="EXISTENCE:mutant phenotype:GO:1900063 regulation of peroxisome organization [PMID:28049721]" /note="Regulator of peroxisome abundance; peroxisomal membrane protein, remote homolog to several curvature-generating human proteins; functionally interacts with vesicle-budding-inducing ADP-ribosylation factor Arf1p" /db_xref="GeneID:853078" /db_xref="SGD:S000003400" ORIGIN 1 mkhnrpngtg kavsgfkqii rrlllllnkk rrkqlviilk ritqvyginl vfyvkkwklk 61 klqgeniqin dimpwlrest ilvllnilyp tlmkfpflkn hyihwssivg islmltkgev 121 pswiiahflv eaiasklkia kltqwlkkkn fsqgtlikfq qilvclaiiv lfakldrssl 181 pfrvlfdhrp flidfftina iftvlavyhr tlkffftsgt ksnknvgghe vrnfsqylgv 241 knhndwpiss snlkhvmdrl neihevtidd nyaninekii nsyftkgffp slkwtilrqc 301 ieylfvtkrr rlmgnklrci vmlltftfvd ptskmkispf fakffakslv nvylkkywhc 361 nfgkyilffl fqlsim // LOCUS NP_011685 404 aa linear PLN 30-JUN-2025 DEFINITION pseudouridine synthase PUS6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011685 VERSION NP_011685.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181298.3 REFERENCE 1 (residues 1 to 404) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 404) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 404) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 404) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08263. On Jul 30, 2012 this sequence version replaced NP_011685.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..404 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..404 /product="pseudouridine synthase PUS6" /EC_number="5.4.99.42" /calculated_mol_wt="46685" Region 104..400 /region_name="PseudoU_synth_ScRIB2" /note="Pseudouridine synthases similar to Saccharomyces cerevisiae RIB2; cd02557" /db_xref="CDD:211331" Site order(165..168,288) /site_type="active" /note="probable active site [active]" /db_xref="CDD:211331" CDS 1..404 /gene="PUS6" /locus_tag="YGR169C" /coded_by="NM_001181298.3:1..1215" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11406626]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11406626]" /experiment="EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:11406626]" /experiment="EXISTENCE:direct assay:GO:0031119 tRNA pseudouridine synthesis [PMID:11406626]" /experiment="EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:11406626]" /experiment="EXISTENCE:mutant phenotype:GO:0031119 tRNA pseudouridine synthesis [PMID:11406626]" /note="tRNA:pseudouridine synthase; catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability" /db_xref="GeneID:853079" /db_xref="SGD:S000003401" ORIGIN 1 mstikvievy tqnglrkvrp yynrrsafvk grwlgkllid vlvsefklrp rayyldqirk 61 gtyrlirdgv plvpdhlmtt iiknhdvlet tthkheppvk qwcsqeveae dlpgriagfn 121 ivfedesilv idkpsgipvh ptgqfyqnti tellklhgvd alpcyrldki tsgllilakn 181 sqsageiqks irsrdmikiy larvkgrfph selildnena aettfedtsk vtvemtpiys 241 idpkrqfpvg lstskdaitk fypiryfsha detvvackpi tgrthqirih larlghpivn 301 dsvycshitk yperlkfitq fprwenqqdl daeelkvrfq kfvdetknnc rtmetfcpec 361 htvdlkdpvl sdlelwlhaw kyeeingkfk fktdlpkwaq ldns // LOCUS NP_878080 92 aa linear PLN 30-JUN-2025 DEFINITION Lso2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878080 VERSION NP_878080.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184531.3 REFERENCE 1 (residues 1 to 92) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 92) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 92) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 92) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08264. On Jul 30, 2012 this sequence version replaced NP_878080.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..92 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..92 /product="Lso2p" /calculated_mol_wt="10364" CDS 1..92 /gene="LSO2" /locus_tag="YGR169C-A" /gene_synonym="YGR169C-C" /coded_by="NM_001184531.3:1..279" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26450372]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26450372]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:30208026]" /experiment="EXISTENCE:mutant phenotype:GO:0002182 cytoplasmic translational elongation [PMID:30208026]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:26450372]" /experiment="EXISTENCE:mutant phenotype:GO:0031670 cellular response to nutrient [PMID:30208026]" /note="Ribosome-associated protein; required for global translational elongation after recovery from stationary phase due to starvation; crosslinks to the 25S rRNA near the A site that overlaps the GTPase activation center, and to tRNAs; possible role in the iron deprivation response; localizes to the nucleus and cytoplasm, with enhanced nuclear localization under iron-replete conditions; null mutant exhibits slow growth during iron deprivation; orthologous to human CCDC124" /db_xref="GeneID:1466460" /db_xref="SGD:S000028521" ORIGIN 1 mgkrfsesaa kkaaglarkr dqahakqraq meqleaeeas kweqgsrken akkleeeqkr 61 qekarakker dalltaeeeq lgkggkgkrk mk // LOCUS NP_011686 1138 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylserine decarboxylase 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011686 VERSION NP_011686.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181299.1 REFERENCE 1 (residues 1 to 1138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1138) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08265. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1138 /product="phosphatidylserine decarboxylase 2" /EC_number="4.1.1.65" /calculated_mol_wt="129934" Region 19..>86 /region_name="C2" /note="C2 domain; cd00030" /db_xref="CDD:175973" Region 523..1079 /region_name="PLN02964" /note="phosphatidylserine decarboxylase" /db_xref="CDD:215520" CDS 1..1138 /gene="PSD2" /locus_tag="YGR170W" /coded_by="NM_001181299.1:1..3417" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:20016005]" /experiment="EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:6427211]" /experiment="EXISTENCE:genetic interaction:GO:0004609 phosphatidylserine decarboxylase activity [PMID:14660568]" /note="Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes; converts phosphatidylserine to phosphatidylethanolamine; controls vacuolar membrane phospholipid content by regulating phospholipids in compartments that will eventually give rise to the vacuole; loss of Psd2p causes a specific reduction in vacuolar membrane PE levels while total PE levels are not significantly affected" /db_xref="GeneID:853080" /db_xref="SGD:S000003402" ORIGIN 1 mriikgrkrg knkkptlilk ihviqaenie alktfncnpv cfvttntfys qktnklknsn 61 thwnqtlrik lprnptsewl riivydalpt gappttpsrp rtttantsss tlsnsglssh 121 shssrnlnvt skgnqtstsi nsvsssatpa pshsssslst tgpgsthknr insylylgea 181 kislldlfkr kdtttsykfs ieaqryhlyd mkggkdqdsl ncnflvgdil lgfklecnvk 241 rtptfqafna wrnelntylg ridrnkarmr sssslppple dmlsnssavs gneirrekpy 301 sdtdlahdee vnaedeidae esiedmnssg sicterrydi dndtifdsis evvslndeel 361 dilndfeead hpnvpdinvh didedtrisl ssmitaldey divepedvak lpavsendit 421 svddeesenq qesdeefdiy nederedsdf qskeyigsrl lhlqrgkhnk syanylyrra 481 ksnffiskke hamgvvfmhi gaiknlpalr nrlsktnyem dpfivisfgr rvfktswrkh 541 tlnpefneya afevfphetn fafsikvvdk dsfsfnddva kcelawfdml qqqqhenewi 601 pyeipldltv epahapkqpv lyssfkyvsy pflkksfwke avdtsvnler ldiiqvmlyl 661 erlgsftmad sfelfqhfnk sawagqsitr sqlveglqsw rkstnfkriw tcprcmrsck 721 ptrnarrskl vlendlithf aictfskehk tlkpsyvssa faskrwfskv likltygkya 781 lgsnnanilv qdrdtgiiie ekisahvklg mriiyngksp eskkfrsllk tlsirqgkkf 841 dstasakqie pfikfhsldl sqcrdkdfkt fneffyrklk pgsrlpesnn keilfspads 901 rctvfptiqe skeiwvkgrk fsikklanny npetfndnnc sigifrlapq dyhrfhspcn 961 gtigkpvyvd geyytvnpma vrseldvfge nirviipids pqfgkllyip igammvgsil 1021 ltckendvve sgqelgyfkf ggstiiiiip hnnfmfdsdl vknsseriet lvkvgmsigh 1081 tsnvnelkri rikvddpkki erikrtisvs denakstgnv tweyhtlrem mnkdfagl // LOCUS NP_011687 575 aa linear PLN 30-JUN-2025 DEFINITION methionine--tRNA ligase MSM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011687 VERSION NP_011687.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181300.1 REFERENCE 1 (residues 1 to 575) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 575) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 575) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 575) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08266. Method: conceptual translation. FEATURES Location/Qualifiers source 1..575 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..575 /product="methionine--tRNA ligase MSM1" /EC_number="6.1.1.10" /calculated_mol_wt="66604" Region 15..550 /region_name="metG" /note="methionine--tRNA ligase; TIGR00398" /db_xref="CDD:273058" CDS 1..575 /gene="MSM1" /locus_tag="YGR171C" /coded_by="NM_001181300.1:1..1728" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:2645139|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0004825 methionine-tRNA ligase activity [PMID:2645139]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:2645139]" /experiment="EXISTENCE:mutant phenotype:GO:0006431 methionyl-tRNA aminoacylation [PMID:2645139]" /note="Mitochondrial methionyl-tRNA synthetase (MetRS); functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p" /db_xref="GeneID:853081" /db_xref="SGD:S000003403" ORIGIN 1 mqcrsivhrl yskvshvttp ifypnakphl ghlyssllsd vyhrwqlfkg nlsffttgtd 61 ehglkiqcas esngfdqpkk fvdklypefv qldkiyginy trfirttdpd hienvmklwe 121 lclkngyiym gehkgwysis detfypeskv ikdpkndgky lntesknevv yqsetnyffr 181 lslfnkkivd hirknpdfif paskrdqilk eletggtlpd lsisrpsarl kwgiptpndp 241 sqkvyvwfda lcnylssigg ipsilsnate vvsrhysdks nvkgqllipy pkevqrntih 301 vigkdiakfh tvywpsflla aglplprqiv vhghwlcngm kmskslgnvv dpidmaryyg 361 adivrwflle nskleedgdf qeaklyetre llvskwgnli nrccgskfni eravmkfsdk 421 anfqfqeifq nepivserie nlakllnksq evfdekiaif qypqllrhvw siindantlv 481 qnskpwerel dqqdniifla metsrilsil cqsiipslsq sfldridvsk ekrtinyarl 541 gsdktygkqs nkkgrevplk kipfrlqeeq tnmrs // LOCUS NP_011688 248 aa linear PLN 30-JUN-2025 DEFINITION transporter YIP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011688 VERSION NP_011688.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181301.3 REFERENCE 1 (residues 1 to 248) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 248) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 248) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 248) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08267. On Jul 30, 2012 this sequence version replaced NP_011688.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..248 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..248 /product="transporter YIP1" /calculated_mol_wt="26949" Region 3..248 /region_name="YIP1" /note="Rab GTPase interacting factor, Golgi membrane protein [Intracellular trafficking and secretion]; COG5080" /db_xref="CDD:227412" CDS 1..248 /gene="YIP1" /locus_tag="YGR172C" /coded_by="NM_001181301.3:1..747" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:9724632]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:14557247|PMID:15659647]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:15659647]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:15659647]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:9724632]" /experiment="EXISTENCE:mutant phenotype:GO:0048280 vesicle fusion with Golgi apparatus [PMID:12657649]" /experiment="EXISTENCE:physical interaction:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:15659647]" /note="Integral membrane protein; required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; human homolog YIPF5 can complement yeast yip1 mutant" /db_xref="GeneID:853082" /db_xref="SGD:S000003404" ORIGIN 1 msfyntsnna nngggfyqps aqfavpqgsm sfqntvgssn tgndnnlgva pdplpvgilh 61 alstkgyphe pplleeigin fdhiitktkm vlipirfgsg vpqeilndsd lagpliffll 121 fglfllmagk vhfgyiygva lfgtislhnl sklmsnndts tqtnlqffnt asilgycflp 181 lcflsllgif hglnnttgyv vsvlfviwst wtssgflnsl lqlqnarlli aypllifysv 241 falmvifv // LOCUS NP_011689 368 aa linear PLN 30-JUN-2025 DEFINITION Rbg2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011689 VERSION NP_011689.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181302.1 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08268. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..368 /product="Rbg2p" /calculated_mol_wt="40875" Region 1..368 /region_name="Rbg1" /note="Ribosome-interacting GTPase RBG1 [Translation, ribosomal structure and biogenesis]; COG1163" /db_xref="CDD:440777" CDS 1..368 /gene="RBG2" /locus_tag="YGR173W" /gene_synonym="GIR1" /coded_by="NM_001181302.1:1..1107" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:21076151]" /experiment="EXISTENCE:genetic interaction:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:23899355]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:23899355]" /note="Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein" /db_xref="GeneID:853083" /db_xref="SGD:S000003405" ORIGIN 1 mgiidkikai eeemartqkn katehhlgll kgklaryrqq lladeagsgg gggsgfevak 61 sgdarvvlig ypsvgkssll gkitttksei ahyafttlts vpgvlkyqga eiqivdlpgi 121 iygasqgkgr grqvvatart adlvlmvlda tksehqrasl ekelenvgir lnkekpniyy 181 kkketggvkv tftsppktnl teqaikmilr dyrihnaevl vrddqctidd fidvineqhr 241 nyvkclyvyn kidavsleev dklarepntv vmscemdlgl qdvveeiwyq lnlsrvytkk 301 rgvrpvfddp lvvrnnstig dlchgihrdf kdkfkyalvw gssakhspqk cglnhridde 361 dvvslfak // LOCUS NP_011690 170 aa linear PLN 30-JUN-2025 DEFINITION Cbp4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011690 VERSION NP_011690.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181303.3 REFERENCE 1 (residues 1 to 170) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 170) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 170) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 170) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08269. On Jul 30, 2012 this sequence version replaced NP_011690.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..170 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..170 /product="Cbp4p" /calculated_mol_wt="20088" Region 28..151 /region_name="CBP4" /note="pfam07960" /db_xref="CDD:369619" CDS 1..170 /gene="CBP4" /locus_tag="YGR174C" /coded_by="NM_001181303.3:1..513" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:8063753]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:8063753]" /experiment="EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:8063753|PMID:15759116]" /note="Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex" /db_xref="GeneID:853085" /db_xref="SGD:S000003406" ORIGIN 1 mqcaitprea viakqrqykh ylgmerplwv rwlkvyaigg aiigsgfllf kyttptdqql 61 isqlspelrl qyerekklrq seqqalmkiv ketsqsddpi wktgplqspw erngdnvqsr 121 dhfakvraee vqkeelarir nelsqlrset eektkeivqd kqvkswwrfw // LOCUS NP_878081 28 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR174W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878081 VERSION NP_878081.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184595.3 REFERENCE 1 (residues 1 to 28) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 28) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 28) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 28) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08270. On Jul 30, 2012 this sequence version replaced NP_878081.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..28 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..28 /product="uncharacterized protein" /calculated_mol_wt="3264" CDS 1..28 /locus_tag="YGR174W-A" /coded_by="NM_001184595.3:1..87" /note="hypothetical protein; predicted to have a role in cell budding based on computational 'guilt by association' analysis" /db_xref="GeneID:1466461" /db_xref="SGD:S000028639" ORIGIN 1 mnlnayfeay qaifpfllea flrkeqkv // LOCUS NP_011691 496 aa linear PLN 30-JUN-2025 DEFINITION squalene monooxygenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011691 VERSION NP_011691.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181304.1 REFERENCE 1 (residues 1 to 496) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 496) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 496) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 496) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08271. Method: conceptual translation. FEATURES Location/Qualifiers source 1..496 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..496 /product="squalene monooxygenase" /EC_number="1.14.14.17" /calculated_mol_wt="54995" Region 26..>219 /region_name="FixC" /note="Dehydrogenase (flavoprotein) [Energy production and conversion]; COG0644" /db_xref="CDD:440409" Region 201..473 /region_name="SE" /note="Squalene epoxidase; pfam08491" /db_xref="CDD:400679" CDS 1..496 /gene="ERG1" /locus_tag="YGR175C" /coded_by="NM_001181304.1:1..1491" /experiment="EXISTENCE:direct assay:GO:0004506 squalene monooxygenase activity [PMID:8358382|PMID:9450962]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:9450962|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093|PMID:9450962]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:8358382]" /experiment="EXISTENCE:mutant phenotype:GO:0004506 squalene monooxygenase activity [PMID:200835]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:200835]" /note="Squalene epoxidase; catalyzes epoxidation of squalene to 2,3-oxidosqualene; plays essential role in ergosterol-biosynthesis pathway and is specific target of antifungal drug terbinafine; directed to ER via guided entry of tail-anchored proteins (GET) pathway; degradation by ERAD triggered by membrane lipid saturation; human SQLE functionally complements the lethality of the erg1 null mutation" /db_xref="GeneID:853086" /db_xref="SGD:S000003407" ORIGIN 1 msavnvapel inadntityd aivigagvig pcvatglark gkkvliverd wampdrivge 61 lmqpggvral rslgmiqsin nieaypvtgy tvffngeqvd ipypykadip kveklkdlvk 121 dgndkvleds tihikdyedd erergvafvh grflnnlrni taqepnvtrv qgncieilkd 181 eknevvgakv didgrgkvef kahltficdg ifsrfrkelh pdhvptvgss fvgmslfnak 241 npapmhghvi lgsdhmpilv yqispeetri lcaynspkvp adikswmikd vqpfipkslr 301 psfdeavsqg kframpnsyl parqndvtgm cvigdalnmr hpltgggmtv glhdvvllik 361 kigdldfsdr ekvldelldy hferksydsv invlsvalys lfaadsdnlk alqkgcfkyf 421 qrggdcvnkp veflsgvlpk plqltrvffa vafytiylnm eergflglpm allegimili 481 tairvftpfl fgelig // LOCUS NP_011693 535 aa linear PLN 30-JUN-2025 DEFINITION alcohol O-acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011693 VERSION NP_011693.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181306.1 REFERENCE 1 (residues 1 to 535) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 535) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 535) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 535) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08272. Method: conceptual translation. FEATURES Location/Qualifiers source 1..535 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..535 /product="alcohol O-acetyltransferase" /EC_number="2.3.1.84" /calculated_mol_wt="61767" Region 23..529 /region_name="AATase" /note="Alcohol acetyltransferase; pfam07247" /db_xref="CDD:369286" CDS 1..535 /gene="ATF2" /locus_tag="YGR177C" /coded_by="NM_001181306.1:1..1608" /experiment="EXISTENCE:direct assay:GO:0004026 alcohol O-acetyltransferase activity [PMID:9836419]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:18034159]" /experiment="EXISTENCE:genetic interaction:GO:1901089 acetate ester metabolic process involved in fermentation [PMID:12957907]" /experiment="EXISTENCE:mutant phenotype:GO:0008202 steroid metabolic process [PMID:10103065]" /experiment="EXISTENCE:mutant phenotype:GO:0009636 response to toxic substance [PMID:18034159]" /note="Alcohol acetyltransferase; may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking" /db_xref="GeneID:853088" /db_xref="SGD:S000003409" ORIGIN 1 mediegyeph itqelidrgh arrmghleny favlsrqkmy snftvyaeln kgvnkrqlml 61 vlkvllqkys tlahtiipkh yphheayyss eeylskpfpq hdfikvishl efddlimnnq 121 peyrevmeki seqfkkddfk vtnrlielis pviiplgnpk rpnwrliclp gkdtdgfetw 181 knfvyvtnhc gsdgvsgsnf fkdlallfck ieekgfdyde efiedqviid ydrdyteisk 241 lpkpitdrid ykpaltslpk fflttfiyeh cnfktssest ltaryspssn anasynyllh 301 fstkqveqir aqikknvhdg ctltpfiqac flvalyrldk lftkslleyg fdvaipsnar 361 rflpndeelr dsykygsnvg gshyayliss fdipegdndk fwslveyyyd rflesydngd 421 hliglgvlql dfivenknid sllansylhq qrggaiisnt glvsqdttkp yyvrdlifsq 481 sagalrfafg lnvcstnvng mnmdmsvvqg tlrdrgewes fcklfyqtig efasl // LOCUS NP_011694 722 aa linear PLN 30-JUN-2025 DEFINITION Pbp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011694 VERSION NP_011694.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181307.3 REFERENCE 1 (residues 1 to 722) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 722) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 722) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 722) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 722) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 722) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 722) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 722) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08273. On Jul 30, 2012 this sequence version replaced NP_011694.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..722 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..722 /product="Pbp1p" /calculated_mol_wt="78651" Region 54..131 /region_name="SM-ATX" /note="Ataxin 2 SM domain; pfam14438" /db_xref="CDD:464173" Region 226..291 /region_name="LsmAD" /note="LsmAD domain; pfam06741" /db_xref="CDD:461998" CDS 1..722 /gene="PBP1" /locus_tag="YGR178C" /gene_synonym="MRS16" /coded_by="NM_001181307.3:1..2169" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:30982600]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0043007 maintenance of rDNA [PMID:25073155]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:15082763]" /experiment="EXISTENCE:mutant phenotype:GO:1901524 regulation of mitophagy [PMID:30982600]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:30982600]" /experiment="EXISTENCE:physical interaction:GO:0045727 positive regulation of translation [PMID:15082763]" /note="Component of glucose deprivation induced stress granules; involved in P-body-dependent granule assembly; regulates TORC1 signaling and autophagy; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation; regulates expression of genes involved in gluconeogenesis and mitochondrial function through multiple mechanisms" /db_xref="GeneID:853089" /db_xref="SGD:S000003410" ORIGIN 1 mkgnfrkrds stnsrkggns dsnytnggvp nqnnssmfye npeitrnfdd rqdyllansi 61 gsdvtvtvts gvkytgllvs cnlestngid vvlrfprvad sgvsdsvddl aktlgetlli 121 hgedvaelel knidlsldek wenskaqett partnieker vngesnevtk frtdvdisgs 181 greikerkle kwtpeegaeh fdinkgkale ddsaswdqfa vnekkfgvks tfdehlyttk 241 inkddpnysk rlqeaeriak eiesqgtsgn ihiaedrgii iddsgldeed lysgvdrrgd 301 ellaalksns kpnsnkgnry vpptlrqqph hmdpaiisss nsnknenavs tdtstpaaag 361 apegkppqkt sknkkslssk eaqieelkkf sekfkvpydi pkdmlevlkr ssstlksnss 421 lppkpisktp saktvspttq isagksesrr sgsnisqgqs stghttrsst slrrrnhgsf 481 fgaknphtnd akrvlfgksf nmfikskeah dekkkgddas enmepffiek pyftaptwln 541 tieesyktff pdedtaiqea qtrfqqrqln smgnavpgmn pamgmnmggm mgfpmggpsa 601 spnpmmngfa agsmgmympf qpqpmfyhps mpqmmpvmgs ngaeegggni sphvpagfma 661 agpgapmgaf gypggipfqg mmgsgpsgmp angsamhshg hsrnyhqtsh hghhnsstsg 721 hk // LOCUS NP_011695 406 aa linear PLN 30-JUN-2025 DEFINITION Okp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011695 VERSION NP_011695.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181308.1 REFERENCE 1 (residues 1 to 406) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 406) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 406) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 406) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08274. Method: conceptual translation. FEATURES Location/Qualifiers source 1..406 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..406 /product="Okp1p" /calculated_mol_wt="47218" CDS 1..406 /gene="OKP1" /locus_tag="YGR179C" /coded_by="NM_001181308.1:1..1221" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:10323865]" /experiment="EXISTENCE:direct assay:GO:0000817 COMA complex [PMID:14633972]" /experiment="EXISTENCE:mutant phenotype:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:19597337]" /note="Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7" /db_xref="GeneID:853090" /db_xref="SGD:S000003411" ORIGIN 1 maadrdnflq niendsinng qamdlspnrs ssesdssilm nvndiktlrl dvapeakstq 61 skkslfyens ddaeegeiee rtnkeegqyh hkgskqlrfe vgkestgklq shlsdgsats 121 gegnvrpwef rkviqaeyre rlprnyelkh wkkpskimig silrlletnt vsaldsvfek 181 yekemnqmth gdnnevkriy skkerlleii ltkikkklrq akfpsriser dldieyiysk 241 rqfiqnrysq elqnnerlea ilsreqnlle etrklcmnlk tnnkkrltek liqkdlhpvl 301 nkameytygl estngfmhpd gpvtfrndsh elnlmlndpi kstadvrldk eevlsllpsl 361 keytkkskel ketmgqmisd sheeeikevf vphheshqdk teedih // LOCUS NP_011696 345 aa linear PLN 30-JUN-2025 DEFINITION ribonucleotide-diphosphate reductase subunit RNR4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011696 VERSION NP_011696.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181309.3 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08275. On Jul 30, 2012 this sequence version replaced NP_011696.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..345 /product="ribonucleotide-diphosphate reductase subunit RNR4" /EC_number="1.17.4.1" /calculated_mol_wt="39924" Region 18..345 /region_name="Ferritin_like" /note="Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; cl00264" /db_xref="CDD:469698" Site order(35,46,53,118..119,122,125..126,129,132,148..149,152) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153108" Site order(57,93,124,127,131,218..219,223) /site_type="active" /note="putative radical transfer pathway [active]" /db_xref="CDD:153108" Site order(93,124,127,186,220,223) /site_type="other" /note="diiron center [ion binding]" /db_xref="CDD:153108" Site 131 /site_type="other" /note="tyrosyl radical" /db_xref="CDD:153108" CDS 1..345 /gene="RNR4" /locus_tag="YGR180C" /gene_synonym="CRT3; PSO3" /coded_by="NM_001181309.3:1..1038" /experiment="EXISTENCE:direct assay:GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [PMID:10716984|PMID:10535923]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:12732713|PMID:9315670]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:12732713]" /experiment="EXISTENCE:direct assay:GO:0005971 ribonucleoside-diphosphate reductase complex [PMID:10716984]" /experiment="EXISTENCE:direct assay:GO:0009263 deoxyribonucleotide biosynthetic process [PMID:10535923|PMID:5459124]" /experiment="EXISTENCE:genetic interaction:GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [PMID:9315670|PMID:9315671]" /experiment="EXISTENCE:mutant phenotype:GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [PMID:16285741|PMID:9315671]" /experiment="EXISTENCE:physical interaction:GO:0005971 ribonucleoside-diphosphate reductase complex [PMID:9315670]" /note="Ribonucleotide-diphosphate reductase (RNR) small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; relocalizes from nucleus to cytoplasm upon DNA replication stress; RNR4 has a paralog, RNR2, that arose from the whole genome duplication" /db_xref="GeneID:853091" /db_xref="SGD:S000003412" ORIGIN 1 meahnqflkt fqkerhdmke aekdeillme nsrrfvmfpi kyheiwaayk kveasfwtae 61 eielakdted fqkltddqkt yignllalsi ssdnlvnkyl ienfsaqlqn pegksfygfq 121 immeniysev ysmmvdaffk dpkniplfke ianlpevkhk aafierwisn ddslyaerlv 181 afaakegifq agnyasmfwl tdkkimpgla manrnicrdr gaytdfscll fahlrtkpnp 241 kiiekiitea veiekeyysn slpvekfgmd lksihtyief vadgllqgfg nekyynavnp 301 fefmedvata gkttffekkv sdyqkasdms ksatpskein fdddf // LOCUS NP_011697 105 aa linear PLN 30-JUN-2025 DEFINITION protein translocase subunit TIM13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011697 VERSION NP_011697.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181310.3 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08276. On Jul 30, 2012 this sequence version replaced NP_011697.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..105 /product="protein translocase subunit TIM13" /calculated_mol_wt="11155" Region 35..94 /region_name="zf-Tim10_DDP" /note="Tim10/DDP family zinc finger; pfam02953" /db_xref="CDD:460764" CDS 1..105 /gene="TIM13" /locus_tag="YGR181W" /coded_by="NM_001181310.3:1..318" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:10051608|PMID:10397776]" /experiment="EXISTENCE:direct assay:GO:0042719 mitochondrial intermembrane space protein transporter complex [PMID:12221072]" /experiment="EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:10469659|PMID:10051608]" /experiment="EXISTENCE:direct assay:GO:0140318 protein transporter activity [PMID:10469659|PMID:10051608]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:10469659]" /experiment="EXISTENCE:mutant phenotype:GO:0140318 protein transporter activity [PMID:10469659]" /experiment="EXISTENCE:physical interaction:GO:0042719 mitochondrial intermembrane space protein transporter complex [PMID:10051608]" /note="Mitochondrial intermembrane space protein; forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane" /db_xref="GeneID:853093" /db_xref="SGD:S000003413" ORIGIN 1 mglssifggg apsqqkeaat takttpnpia kelknqiaqe lavanatelv nkisencfek 61 cltspyatrn dacidqclak ymrswnvisk ayisriqnas asgei // LOCUS NP_011699 66 aa linear PLN 30-JUN-2025 DEFINITION ubiquinol--cytochrome-c reductase subunit 9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011699 VERSION NP_011699.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181312.1 REFERENCE 1 (residues 1 to 66) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 66) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 66) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 66) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08277. Method: conceptual translation. FEATURES Location/Qualifiers source 1..66 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..66 /product="ubiquinol--cytochrome-c reductase subunit 9" /calculated_mol_wt="7345" Region 7..56 /region_name="UCR_UQCRX_QCR9" /note="Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like; pfam05365" /db_xref="CDD:461632" CDS 1..66 /gene="QCR9" /locus_tag="YGR183C" /gene_synonym="UCR9" /coded_by="NM_001181312.1:1..201" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:10873857]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:10873857]" /experiment="EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:1332881]" /experiment="EXISTENCE:mutant phenotype:GO:0008121 quinol-cytochrome-c reductase activity [PMID:1332881]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:1332881]" /experiment="EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:8389362]" /note="Subunit 9 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex" /db_xref="GeneID:853095" /db_xref="SGD:S000003415" ORIGIN 1 msfsslyktf fkrnavfvgt ifagafvfqt vfdtaitswy enhnkgklwk dvkariaagd 61 gdddde // LOCUS NP_011700 1950 aa linear PLN 30-JUN-2025 DEFINITION E3 ubiquitin-protein ligase UBR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011700 VERSION NP_011700.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181313.1 REFERENCE 1 (residues 1 to 1950) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1950) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1950) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1950) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1950) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08278. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1950 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1950 /product="E3 ubiquitin-protein ligase UBR1" /EC_number="2.3.2.27" /calculated_mol_wt="224708" Region 123..190 /region_name="UBR-box_UBR1_like" /note="UBR-box found in ubiquitin-protein ligases, E3-alpha-1 (UBR1), E3-alpha-2 (UBR2), and similar proteins; cd19672" /db_xref="CDD:439070" Site order(123,136,139,148,151,157,160,175,177,189) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:439070" Region 308..>358 /region_name="ClpS" /note="ATP-dependent Clp protease adaptor protein ClpS; cl00933" /db_xref="CDD:469998" Region 1286..1332 /region_name="RING-H2_UBR1-like" /note="RING finger, H2 subclass, found in ubiquitin-protein ligase E3-alpha-1 (UBR1), E3-alpha-2 (UBR2), and similar proteins; cd16482" /db_xref="CDD:438145" Region 1402..1793 /region_name="PRT6_C" /note="Proteolysis_6 C-terminal; pfam18995" /db_xref="CDD:465944" CDS 1..1950 /gene="UBR1" /locus_tag="YGR184C" /gene_synonym="PTR1" /coded_by="NM_001181313.1:1..5853" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:20462952]" /experiment="EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:20462952]" /experiment="EXISTENCE:genetic interaction:GO:0005737 cytoplasm [PMID:20080635]" /experiment="EXISTENCE:genetic interaction:GO:0034620 cellular response to unfolded protein [PMID:20462952]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:23988329]" /experiment="EXISTENCE:genetic interaction:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:20462952]" /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:10581257|PMID:2209542]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:10581257]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:20080635]" /experiment="EXISTENCE:mutant phenotype:GO:0034620 cellular response to unfolded protein [PMID:20462952]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:23988329]" /experiment="EXISTENCE:mutant phenotype:GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway [PMID:2209542]" /experiment="EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:27448207|PMID:20462952|PMID:19041308|PMID:20080635|P MID:22670231]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579]" /experiment="EXISTENCE:mutant phenotype:GO:0090089 regulation of dipeptide transport [PMID:9427760]" /experiment="EXISTENCE:mutant phenotype:GO:0120174 stress-induced homeostatically regulated protein degradation pathway [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23358411]" /experiment="EXISTENCE:physical interaction:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:10688918]" /experiment="EXISTENCE:physical interaction:GO:1904855 proteasome regulatory particle binding [PMID:10688918]" /experiment="EXISTENCE:physical interaction:GO:1990303 UBR1-RAD6 ubiquitin ligase complex [PMID:1651502|PMID:8505328]" /note="E3 Ub-ligase (N-recognin); recognizes and ubiquitinates N-end rule pathway substrates in complex with Rad6p; Roq1p-bound form accelerates degradation of misfolded and native ER membrane and cytosolic proteins as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; role in ER-associated protein degradation; modifies Cup9p to regulate peptide transport; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)" /db_xref="GeneID:853096" /db_xref="SGD:S000003416" ORIGIN 1 msvadddlgs lqghirrtlr sihnlpyfry trgpteradm sralkefiyr ylyfvisnsg 61 enlptlfnah pkqklsnpel tvfpdsleda vdidkitsqq tipfykides rigdvhkhtg 121 rncgrkfkig eplyrchecg cddtcvlcih cfnpkdhvnh hvctdictef tsgicdcgde 181 eawnsplhck aeeqendise dpatnadike edvwndsvni alvelvlaev fdyfidvfnq 241 nieplptiqk ditiklremt qqgkmyeraq flndlkyend ymfdgtttak tspsnspeas 301 pslakidpen ytviiyndey hnysqattal rqgvpdnvhi dlltsridge gramlkcsqd 361 lssvlggffa vqtnglsatl tswseylhqe tckyiilwit hclnipnssf qttfrnmmgk 421 tlcseylnat ecrdmtpvve kyfsnkfdkn dpyryidlsi ladgnqiplg hhkilpesst 481 hslsplindv etptsrtysn trlqhilyfd nrywkrlrkd iqnviiptla ssnlykpifc 541 qqvveifnhi trsvaymdre pqltairecv vqlftcptna knifenqsfl divwsiidif 601 kefckveggv liwqrvqksn ltksysisfk qglytvetll skvhdpnipl rpkeiisllt 661 lcklfngawk ikrkegehvl hedqnfisyl eyttsiysii qtaekvseks kdsidsklfl 721 nairiissfl gnrsltykli ydshevikfs vshervafmn plqtmlsfli ekvslkdaye 781 aledcsdflk isdfslrsvv lcsqidvgfw vrngmsvlhq asyyknnpel gsysrdihln 841 qlailwerdd ipriiynild rwelldwftg evdyqhtvye dkisfiiqqf iafiyqilte 901 rqyfktfssl kdrrmdqikn siiynlymkp lsyskllrsv pdyltedtte fdealeevsv 961 fvepkgladn gvfklkasly akvdplklln lenefessat iikshlakdk deiakvvlip 1021 qvsikqldkd alnlgaftrn tvfakvvykl lqvcldmeds tflnellhlv hgifrddeli 1081 ngkdsipeay lskpicnlll sianaksdvf sesivrkady llekmimkkp nelfeslias 1141 fgnqyvndyk dkklrqgvnl qetekerkrr lakkhqarll akfnnqqtkf mkehesefde 1201 qdndvdmvge kvyesedftc alcqdssstd ffvipayhdh spifrpgnif npnefmpmwd 1261 gfynddekqa yidddvleal kengscgsrk vfvscnhhih hncfkryvqk krfssnafic 1321 plcqtfsnct lplcqtskan tglsldmfle selsldtlsr lfkpfteeny rtinsifslm 1381 isqcqgfdka vrkranfshk dvslilsvhw antismleia srlekpysis ffrsreqkyk 1441 tlknilvcim lftfvigkps mefepypqqp dtvwnqnqlf qyivrsalfs pvslrqtvte 1501 alttfsrqfl rdflqglsda eqvtklyaka skigdvlkvs eqmlfalrti sdvrmeglds 1561 esiiydlayt fllksllpti rrclvfikvl helvkdsene tlvingheve eelefedtae 1621 fvnkalkmit ekeslvdllt tqesivshpy lenipyeycg iiklidlsky lntyvtqske 1681 iklreersqh mknadnrldf kicltcgvkv hlradrhemt khlnkncfkp fgaflmpnss 1741 evclhltqpp snifisapyl nshgevgrna mrrgdlttln lkryehlnrl winneipgyi 1801 srvmgdefrv tilsngflfa fnreprprri pptdeddedm eegedgffte gndemdvdde 1861 tgqaanlfgv gaegiagggv rdffqffenf rntlqpqgng dddapqnppp ilqflgpqfd 1921 gatiirntnp rnldeddsdd nddsdereiw // LOCUS NP_011701 394 aa linear PLN 30-JUN-2025 DEFINITION tyrosine--tRNA ligase TYS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011701 VERSION NP_011701.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181314.3 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08279. On Jul 30, 2012 this sequence version replaced NP_011701.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..394 /product="tyrosine--tRNA ligase TYS1" /EC_number="6.1.1.1" /calculated_mol_wt="43889" Region 9..344 /region_name="tyrS" /note="tyrosyl-tRNA synthetase; TIGR00234" /db_xref="CDD:272976" CDS 1..394 /gene="TYS1" /locus_tag="YGR185C" /gene_synonym="TTS1" /coded_by="NM_001181314.3:1..1185" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004831 tyrosine-tRNA ligase activity [PMID:8509419|PMID:782885]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11359929]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11359929]" /experiment="EXISTENCE:direct assay:GO:0006437 tyrosyl-tRNA aminoacylation [PMID:782885|PMID:8509419]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:11359929]" /note="Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; human ortholog YARS functionally complements the heat sensitivity of a ts allele; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853097" /db_xref="SGD:S000003417" ORIGIN 1 mssaatvdpn eafglitknl qevlnpqiik dvlevqkrhl klywgtaptg rphcgyfvpm 61 tkladflkag cevtvlladl hafldnmkap levvnyraky yeltikailr sinvpieklk 121 fvvgssyqlt pdytmdifrl snivsqndak ragadvvkqv anpllsgliy plmqaldeqf 181 ldvdcqfggv dqrkifvlae enlpslgykk rahlmnpmvp glaqggkmsa sdpnskidll 241 eepkqvkkki nsafcspgnv eengllsfvq yviapiqelk fgtnhfeffi drpekfggpi 301 tyksfeemkl afkeeklspp dlkigvadai nellepirqe fannkefqea sekgypvatp 361 qkskkakkpk nkgtkypgat ktneiatkle etkl // LOCUS NP_011702 735 aa linear PLN 30-JUN-2025 DEFINITION transcription factor IIF subunit TFG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011702 VERSION NP_011702.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181315.1 REFERENCE 1 (residues 1 to 735) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 735) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 735) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 735) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 735) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 735) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 735) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 735) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08280. Method: conceptual translation. FEATURES Location/Qualifiers source 1..735 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..735 /product="transcription factor IIF subunit TFG1" /calculated_mol_wt="82064" Region <160..>287 /region_name="PRK10856" /note="cytoskeleton protein RodZ" /db_xref="CDD:236776" Region 318..>580 /region_name="TFIIF_alpha" /note="Transcription initiation factor IIF, alpha subunit (TFIIF-alpha); pfam05793" /db_xref="CDD:310411" CDS 1..735 /gene="TFG1" /locus_tag="YGR186W" /gene_synonym="RAP74; SSU71" /coded_by="NM_001181315.1:1..2208" /experiment="EXISTENCE:direct assay:GO:0005674 transcription factor TFIIF complex [PMID:7995524|PMID:12242279]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:18362165|PMID:1331084]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:18362165]" /experiment="EXISTENCE:direct assay:GO:0072542 protein phosphatase activator activity [PMID:11904169]" /experiment="EXISTENCE:genetic interaction:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:7724527|PMID:16081422|PMID:15572698|PMID:16147988]" /experiment="EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:18362165|PMID:15572698|PMID:16081422]" /experiment="EXISTENCE:mutant phenotype:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:18362165]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:18362165]" /note="TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74" /db_xref="GeneID:853098" /db_xref="SGD:S000003418" ORIGIN 1 msrrnppgsr ngggptnasp fikrdrmrrn flrmrmgqng snssspgvpn gdnsrgslvk 61 kddpeyaeer ekmllqigve adagrsnvkv kdedpneyne fplraipked lenmrthllk 121 fqskkkinpv tdfhlpvrlh rkdtrnlqfq ltraeivqrq keiseykkka eqerstpnsg 181 gmnksgtvsl nntvkdgsqt ptvdsvtkdn tangvnssip tvtgssvppa spttvsaves 241 nglsngstsa angldgnast anlangrplv tkledagpae dptkvgmvky dgkevtnepe 301 feegtmdpla dvapdgggra krgnlrrktr qlkvldenak klrfeefypw vmedfdgynt 361 wvgsyeagns dsyvllsved dgsftmipad kvykftarnk yatltideae krmdkksgev 421 prwlmkhldn igttttrydr trrklkavad qqamdeddrd dnseveldyd eefaddeeap 481 iidgneqenk eseqrikkem lqanamglrd eeapseneed elfgekkide dgerikkalq 541 ktelaalyss deneinpyls esdienkene spvkkeedsd tlskskrssp kkqqkkatna 601 hvhkeptlrv ksikncviil kgdkkilksf pegewnpqtt kavdssnnas ntvpspikqe 661 eglnstvaer eetpaptite kdiieaigdg kvnikefgkf irrkypgaen kklmfaivkk 721 lcrkvgndhm elkke // LOCUS NP_011703 394 aa linear PLN 30-JUN-2025 DEFINITION Hgh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011703 VERSION NP_011703.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181316.3 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08281. On Jul 30, 2012 this sequence version replaced NP_011703.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..394 /product="Hgh1p" /calculated_mol_wt="44820" Region 99..301 /region_name="DUF383" /note="Domain of unknown function (DUF383); pfam04063" /db_xref="CDD:461153" Region 306..360 /region_name="DUF384" /note="Domain of unknown function (DUF384); pfam04064" /db_xref="CDD:461154" CDS 1..394 /gene="HGH1" /locus_tag="YGR187C" /coded_by="NM_001181316.3:1..1185" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0061770 translation elongation factor binding [PMID:30876804]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:30876804]" /note="Chaperone protein for translation factor eEF2; involved in biogenesis of eukaryotic Elongation Factor 2 (Eft1p, Eft2p); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16); relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:853099" /db_xref="SGD:S000003419" ORIGIN 1 mtsqlnelve flhspqpavr qiaidnlvgf sagptskvfk ndsyrpikdi ikmimdpehg 61 trviiqqgvt ilvnlsedkl vrniilsddk kflkflvwki vdltnpnadi mcillsnlak 121 ddgilavlni krnssgeevd dglklaalnk evfkslramd clmdcfvkgy dkkltkyasf 181 nylafffadi srfklgrmyf ieeqeydgvv piskllvfte kydakvrreg vastiknslf 241 dsetherllk dekinllpyi llpiasakds eideedmfnl pdelqllped kerdpipaii 301 cchlesilll ctthagreyl rdksvyplvr elhknvened igelcyrivn mlmrgepgag 361 aveempskna eeeeeeesee eedddeedei veva // LOCUS NP_011704 1021 aa linear PLN 30-JUN-2025 DEFINITION protein kinase BUB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011704 VERSION NP_011704.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181317.3 REFERENCE 1 (residues 1 to 1021) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1021) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1021) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1021) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1021) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1021) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1021) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1021) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08282. On Jul 30, 2012 this sequence version replaced NP_011704.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1021 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1021 /product="protein kinase BUB1" /EC_number="2.7.11.1" /calculated_mol_wt="117738" Region 37..169 /region_name="Mad3_BUB1_I" /note="Mad3/BUB1 hoMad3/BUB1 homology region 1; smart00777" /db_xref="CDD:214817" Region 291..352 /region_name="Mad3_BUB1_II" /note="Mad3/BUB1 homology region 2; pfam08171" /db_xref="CDD:400476" Region 704..1008 /region_name="STKc_Bub1_BubR1" /note="Catalytic domain of the Serine/Threonine kinases, Spindle assembly checkpoint proteins Bub1 and BubR1; cd13981" /db_xref="CDD:270883" Site order(711..715,719,731,733,763,779..782,786,788,833,835, 837..838,840,871,874,892..895) /site_type="active" /db_xref="CDD:270883" Site order(711..715,719,731,733,763,779..782,786,833,835, 837..838,840,871) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270883" Site order(715,786,788,833,835,837,874,892..895) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270883" Site order(870..881,883..889,891..895) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270883" CDS 1..1021 /gene="BUB1" /locus_tag="YGR188C" /coded_by="NM_001181317.3:1..3066" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:27170178|PMID:12769845|PMID:12221113|PMID:24402315]" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:16541024]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:7969164]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7969164]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:1651171]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:18081426]" /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:24402315|PMID:16357219]" /experiment="EXISTENCE:mutant phenotype:GO:0034508 centromere complex assembly [PMID:22365852]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12769845]" /note="Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication" /db_xref="GeneID:853100" /db_xref="SGD:S000003420" ORIGIN 1 mnldlgstvr gyesdkdtfp qskgvsssqk eqhsqlnqtk iayeqrllnd ledmddpldl 61 fldymiwist syievdsesg qevlrstmer cliyiqdmet yrndprflki wiwyinlfls 121 nnfhesentf kymfnkgigt klslfyeefs kllenaqffl eakvllelga enncrpynrl 181 lrslsnyedr lremnivenq nsvpdsrerl kgrliyrtap ffirkfltss lmtddkenra 241 nlnsnvgvgk sapnvyqdsi vvadfksete rlnlnsskqp snqrlkngnk ktsiyadqkq 301 snnpvyklin tpgrkperiv fnfnliypen deefnteeil amikglykvq rrgkkhtedy 361 tsdknrkkrk ldvlverrqd lpssqppvvp kstrievfkd ddnpsqsthh kntqvqvqtt 421 tsilplkpvv dgnlahetpv kpsltsnasr sptvtafskd ainevfsmfn qhystpgall 481 dgddtttskf nvfenftqef takniedlte vkdpkqetvs qqttstnetn dryerlsnss 541 trpekadymt pikettetdv vpiiqtpkeq irtedkksgd ntetqtqlts ttiqsspflt 601 qpepqaekll qtaehseksk ehyptiippf tkiknqppvi ienplsnnlr akflseispp 661 lfqyntfyny nqelkmssll kkihrvsrne nknpivdfkk tgdlycirge lgeggyatvy 721 laessqghlr alkvekpasv weyyimsqve frlrkstilk siinasalhl fldesylvln 781 yasqgtvldl inlqrekaid gngimdeylc mfitvelmkv lekihevgii hgdlkpdncm 841 irlekpgepl gahymrnged gwenkgiyli dfgrsfdmtl lppgtkfksn wkadqqdcwe 901 mragkpwsye adyyglagvi hsmlfgkfie tiqlqngrck lknpfkrywk keiwgvifdl 961 llnsgqasnq alpmtekive irnlieshle qhaenhlrnv ilsieeelsh fqykgkpsrr 1021 f // LOCUS NP_011705 507 aa linear PLN 30-JUN-2025 DEFINITION transglycosylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011705 VERSION NP_011705.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181318.1 REFERENCE 1 (residues 1 to 507) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 507) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 507) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 507) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08283. Method: conceptual translation. FEATURES Location/Qualifiers source 1..507 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..507 /product="transglycosylase" /calculated_mol_wt="52627" Region 74..258 /region_name="GH16_fungal_CRH1_transglycosylase" /note="glycosylphosphatidylinositol-glucanosyltransferase; cd02183" /db_xref="CDD:185692" Site order(94,122,124,126,134,136,138,148,150,164,217,219) /site_type="active" /db_xref="CDD:185692" Site order(134,136,138) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:185692" CDS 1..507 /gene="CRH1" /locus_tag="YGR189C" /coded_by="NM_001181318.1:1..1524" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10757808]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460|PMID:10757808]" /experiment="EXISTENCE:direct assay:GO:0016757 glycosyltransferase activity [PMID:23919454]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006030 chitin metabolic process [PMID:18694928]" /experiment="EXISTENCE:genetic interaction:GO:0016757 glycosyltransferase activity [PMID:18694928]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:18694928]" /experiment="EXISTENCE:mutant phenotype:GO:0006030 chitin metabolic process [PMID:18694928]" /experiment="EXISTENCE:mutant phenotype:GO:0016757 glycosyltransferase activity [PMID:18694928]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:18694928]" /note="Chitin transglycosylase; functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress" /db_xref="GeneID:853102" /db_xref="SGD:S000003421" ORIGIN 1 mkvldlltvl sassllstfa aaestatads ttaasstasc nplkttgctp dtalatsfse 61 dfsssskwft dlkhageiky gsdglsmtla krydnpslks nfyimygkle vilkaangtg 121 ivssfylqsd dldeidiewv ggdntqfqsn ffskgdttty drgefhgvdt ptdkfhnytl 181 dwamdkttwy ldgesvrvls ntssegypqs pmylmmgiwa ggdpdnaagt iewaggetny 241 ndapftmyie kvivtdystg kkytygdqsg swesieadgg siygrydqaq edfavlangg 301 sisssstsss tvsssasstv sssvsstvss sasstvsssv sstvsssssv ssssstspss 361 statssktla sssvttsssi ssfekqssss skktvassst sesiisstkt patvssttrs 421 tvapttqqss vssdspvqdk ggvatssndv tssttqissk ytstiqssss easstnsvqi 481 sngadlaqsl pregklfsvl vallall // LOCUS NP_011707 603 aa linear PLN 30-JUN-2025 DEFINITION histidine permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_011707 VERSION NP_011707.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181320.1 REFERENCE 1 (residues 1 to 603) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 603) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 603) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 603) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08284. Method: conceptual translation. FEATURES Location/Qualifiers source 1..603 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..603 /product="histidine permease" /calculated_mol_wt="65876" Region 88..567 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..603 /gene="HIP1" /locus_tag="YGR191W" /coded_by="NM_001181320.1:1..1812" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005291 high-affinity L-histidine transmembrane transporter activity [PMID:5447432]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:3905514]" /experiment="EXISTENCE:mutant phenotype:GO:0006828 manganese ion transport [PMID:9790586]" /experiment="EXISTENCE:mutant phenotype:GO:0015817 histidine transport [PMID:5447432|PMID:3905514]" /note="High-affinity histidine permease; also involved in the transport of manganese ions" /db_xref="GeneID:853104" /db_xref="SGD:S000003423" ORIGIN 1 mprnplkkey wadvvdgfkp atspafenek esttfvtelt sktdsafpls skdspginqt 61 tnditssdrf rrnedteqed inntnlskdl svrhlltlav ggaigtglyv ntgaalstgg 121 paslvidwvi istclftvin slgelsaafp vvggfnvysm rfiepsfafa vnlnylaqwl 181 vllplelvaa sitikywndk insdawvaif yatialanml dvksfgetef vlsmikilsi 241 igftilgivl scgggphggy iggkywhdpg afvghssgtq fkglcsvfvt aafsysgiem 301 tavsaaeskn pretipkaak rtfwlitasy vtiltligcl vpsndprlln gsssvdaass 361 plviaiengg ikglpslmna iiliavvsva nsavyacsrc mvamahignl pkflnrvdkr 421 grpmnaillt lffgllsfva asdkqaevft wlsalsglst ifcwmainls hirfrqamkv 481 qersldelpf isqtgvkgsw ygfivlflvl iasfwtslfp lggsgasaes ffegylsfpi 541 livcyvghkl ytrnwtlmvk ledmdldtgr kqvdltlrre emrieretla krsfvtrflh 601 fwc // LOCUS NP_011708 332 aa linear PLN 30-JUN-2025 DEFINITION glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011708 VERSION NP_011708.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181321.3 REFERENCE 1 (residues 1 to 332) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 332) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 332) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 332) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08285. On Jul 30, 2012 this sequence version replaced NP_011708.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..332 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..332 /product="glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3" /EC_number="1.2.1.12" /calculated_mol_wt="35616" Region 2..332 /region_name="GapA" /note="Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; COG0057" /db_xref="CDD:439827" CDS 1..332 /gene="TDH3" /locus_tag="YGR192C" /gene_synonym="GLD1; HSP35; HSP36; SSS2" /coded_by="NM_001181321.3:1..999" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:25288528]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:18959479|PMID:37792491]" /experiment="EXISTENCE:direct assay:GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [PMID:3905788]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11158358|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11158358]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:expression pattern:GO:0006094 gluconeogenesis [PMID:3905788]" /experiment="EXISTENCE:expression pattern:GO:0006096 glycolytic process [PMID:3905788]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17726063]" /experiment="EXISTENCE:mutant phenotype:GO:0015886 heme transport [PMID:27247412]" /experiment="EXISTENCE:mutant phenotype:GO:0020037 heme binding [PMID:30012884]" /experiment="EXISTENCE:mutant phenotype:GO:0072593 reactive oxygen species metabolic process [PMID:17726063]" /note="Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bacteria; moonlighting role as an AU-rich mRNA binding protein that binds to the FAS1 mRNA and controls periodic abundance of Fas1p" /db_xref="GeneID:853106" /db_xref="SGD:S000003424" ORIGIN 1 mvrvaingfg rigrlvmria lsrpnvevva lndpfitndy aaymfkydst hgryagevsh 61 ddkhiivdgk kiatyqerdp anlpwgssnv diaidstgvf keldtaqkhi dagakkvvit 121 apsstapmfv mgvneekyts dlkivsnasc ttnclaplak vindafgiee glmttvhslt 181 atqktvdgps hkdwrggrta sgniipsstg aakavgkvlp elqgkltgma frvptvdvsv 241 vdltvklnke ttydeikkvv kaaaegklkg vlgytedavv ssdflgdshs sifdasagiq 301 lspkfvklvs wydneygyst rvvdlvehva ka // LOCUS NP_011709 410 aa linear PLN 30-JUN-2025 DEFINITION Pdx1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011709 VERSION NP_011709.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181322.1 REFERENCE 1 (residues 1 to 410) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 410) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 410) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 410) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08286. Method: conceptual translation. FEATURES Location/Qualifiers source 1..410 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..410 /product="Pdx1p" /calculated_mol_wt="45231" Region 37..>217 /region_name="PDHac_trf_mito" /note="pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; TIGR01349" /db_xref="CDD:273567" CDS 1..410 /gene="PDX1" /locus_tag="YGR193C" /coded_by="NM_001181322.1:1..1233" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:2007123]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006086 pyruvate decarboxylation to acetyl-CoA [PMID:2007123|PMID:7947791]" /experiment="EXISTENCE:direct assay:GO:0045254 pyruvate dehydrogenase complex [PMID:7947791|PMID:2007123]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:2007123]" /experiment="EXISTENCE:mutant phenotype:GO:0006086 pyruvate decarboxylation to acetyl-CoA [PMID:2007123]" /experiment="EXISTENCE:physical interaction:GO:0045254 pyruvate dehydrogenase complex [PMID:7947791]" /note="E3-binding protein of the mitochondrial pyruvate dehydrogenase complex; plays a structural role in the complex by binding and positioning dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide acetyltransferase (E2) core" /db_xref="GeneID:853107" /db_xref="SGD:S000003425" ORIGIN 1 mlsaiskvst lksctryltk cnyhasakll avktfsmpam sptmekggiv swkykvgepf 61 sagdvileve tdksqidvea lddgklakil kdegskdvdv gepiayiadv dddlatiklp 121 qeantanaks ieikkpsads teatqqhlkk atvtpiktvd gsqanleqtl lpsvslllae 181 nniskqkalk eiapsgsngr llkgdvlayl gkipqdsvnk vtefikkner ldlsnikpiq 241 lkpkiaeqaq tkaadkpkit pvefeeqlvf hapasipfdk lseslnsfmk eayqfshgtp 301 lmdtnskyfd pifedlvtls preprfkfsy dlmqipkann mqdtygqedi fdlltgsdat 361 assvrpvekn lpekneyila lnvsvnnkkf ndaeakakrf ldyvrelesf // LOCUS NP_011710 600 aa linear PLN 30-JUN-2025 DEFINITION xylulokinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011710 VERSION NP_011710.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181323.3 REFERENCE 1 (residues 1 to 600) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 600) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 600) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 600) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 600) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08287. On Jul 30, 2012 this sequence version replaced NP_011710.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..600 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..600 /product="xylulokinase" /EC_number="2.7.1.17" /calculated_mol_wt="68190" Region 22..557 /region_name="ASKHA_NBD_FGGY_SpXK-like" /note="nucleotide-binding domain (NBD) of Homo sapiens xylulose kinase (XK) and similar proteins; cd07776" /db_xref="CDD:466795" CDS 1..600 /gene="XKS1" /locus_tag="YGR194C" /coded_by="NM_001181323.3:1..1803" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005998 xylulose catabolic process [PMID:10981687]" /experiment="EXISTENCE:mutant phenotype:GO:0004856 D-xylulokinase activity [PMID:9595677]" /note="Xylulokinase; converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains" /db_xref="GeneID:853108" /db_xref="SGD:S000003426" ORIGIN 1 mlcsviqrqt revsntmsld syylgfdlst qqlkclainq dlkivhsetv efekdlphyh 61 tkkgvyihgd tiecpvamwl ealdlvlsky reakfplnkv mavsgscqqh gsvywssqae 121 slleqlnkkp ekdllhyvss vafarqtapn wqdhstakqc qefeeciggp ekmaqltgsr 181 ahfrftgpqi lkiaqlepea yektktislv snfltsilvg hlveleeada cgmnlydire 241 rkfsdellhl idssskdkti rqklmrapmk nliagticky fiekygfntn ckvspmtgdn 301 laticslplr kndvlvslgt sttvllvtdk yhpspnyhlf ihptlpnhym gmicycngsl 361 arerirdeln kerennyekt ndwtlfnqav lddsessene lgvyfplgei vpsvkainkr 421 vifnpktgmi erevakfkdk rhdaknives qalscrvris pllsdsnass qqrlnedtiv 481 kfdydesplr dylnkrpert ffvggasknd aivkkfaqvi gatkgnfrle tpnscalggc 541 ykamwsllyd snkiavpfdk flndnfpwhv mesisdvdne nwdrynskiv plselektli // LOCUS NP_011711 246 aa linear PLN 30-JUN-2025 DEFINITION exosome non-catalytic core subunit SKI6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011711 VERSION NP_011711.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181324.3 REFERENCE 1 (residues 1 to 246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 246) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08288. On Jul 30, 2012 this sequence version replaced NP_011711.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..246 /product="exosome non-catalytic core subunit SKI6" /calculated_mol_wt="27430" Region 11..237 /region_name="RNase_PH_RRP41" /note="RRP41 subunit of eukaryotic exosome; cd11370" /db_xref="CDD:206775" Site order(35,37,52,54..56,73,75,80,99,102,106,120,125,130, 148..150,157,196..207,210,214) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:206775" Site order(37,55..58,60,113,117,120,148..151,153..155,157,229, 232..233,236..237) /site_type="other" /note="Rrp4 interface [polypeptide binding]" /db_xref="CDD:206775" CDS 1..246 /gene="SKI6" /locus_tag="YGR195W" /gene_synonym="ECM20; RRP41" /coded_by="NM_001181324.3:1..741" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:32554806]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15828860|PMID:17643380]" /experiment="EXISTENCE:genetic interaction:GO:0034473 U1 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:genetic interaction:GO:0034476 U5 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429|PMID:12769863]" /experiment="EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:11030620]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10508172|PMID:9390555]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:9482746]" /experiment="EXISTENCE:mutant phenotype:GO:0016075 rRNA catabolic process [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034473 U1 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10611222|PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034476 U5 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:11030620]" /experiment="EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]" /experiment="EXISTENCE:mutant phenotype:GO:0071051 poly(A)-dependent snoRNA 3'-end processing [PMID:10611222]" /note="Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)" /db_xref="GeneID:853109" /db_xref="SGD:S000003427" ORIGIN 1 msrleiyspe glrldgrrwn elrrfessin thphaadgss ymeqgnnkii tlvkgpkepr 61 lksqmdtska llnvsvnitk fskferskss hknerrvlei qtslvrmfek nvmlniyprt 121 vidieihvle qdggimgsli ngitlalida gismfdyisg isvglydttp lldtnsleen 181 amstvtlgvv gkseklslll vedkipldrl envlaigiag ahrvrdlmde elrkhaqkrv 241 snasar // LOCUS NP_011712 817 aa linear PLN 30-JUN-2025 DEFINITION Fyv8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011712 VERSION NP_011712.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181325.1 REFERENCE 1 (residues 1 to 817) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 817) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 817) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 817) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08289. Method: conceptual translation. FEATURES Location/Qualifiers source 1..817 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..817 /product="Fyv8p" /calculated_mol_wt="90667" Region <197..529 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" CDS 1..817 /gene="FYV8" /locus_tag="YGR196C" /coded_by="NM_001181325.1:1..2454" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /note="hypothetical protein; required for survival upon exposure to K1 killer toxin" /db_xref="GeneID:853110" /db_xref="SGD:S000003428" ORIGIN 1 msteqvgrkk syrwvsasqa sydgagwdss deydyssedg tkgseihkqk isnlpslpkl 61 nytdvngehd entgenkdsn dnnvsksdis psdkevgyls dgvpklmasr esvelqakks 121 sehsksdyls staslkspse nkksphtnra vnedldnlie qisremtpei rqtsdfrrds 181 dscdeiqnea plgeavpsss spveedeksh slgvsmdtne adttfntptr ngnehlssdg 241 dvseqkddef kvsergylad ilpaekeenl qqeddgeves sgalekkeks eektsirnrn 301 stssgqdkva kpkpvanetk tsdngyrnsf fndyqhssds eeddnnegns gssdddnrss 361 vsdkhadinr qskqldttdd dalsytesik ystneteeed nednesiedk nednesiede 421 nedtdsykfs nrekgsillt sdeeeeekgm ssdsdegslk apksgyfskm ignddkgdsa 481 lqpnqidtie ntnlsnsgse lensdgsdee dhinedkvle essvkdstdv dswkpdseal 541 rsgfvqdtan kkappgyvid sngklvdltp asmkprvvst ysemestwda fpskgedddl 601 etirdtktiy dnntiynvpg lignqsnlpp lpmdaqeqln agndnsttdn dnsnntandl 661 aarsasfkse nrtvsqgemt svhepsteem aklgqqnnlp kldmnkllns ktshagkieq 721 lrnykrelde ydtgiqtwin ytlksssnkd kdfiaeeykq hshvreayan addlskkhtv 781 intvasvnqn vthlrrkvfq hsmkpkdlfa sigkkkl // LOCUS NP_011713 547 aa linear PLN 30-JUN-2025 DEFINITION Sng1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011713 VERSION NP_011713.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181326.1 REFERENCE 1 (residues 1 to 547) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 547) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 547) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 547) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08290. Method: conceptual translation. FEATURES Location/Qualifiers source 1..547 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..547 /product="Sng1p" /calculated_mol_wt="61163" Region 112..497 /region_name="DUF3533" /note="Protein of unknown function (DUF3533); pfam12051" /db_xref="CDD:432289" CDS 1..547 /gene="SNG1" /locus_tag="YGR197C" /coded_by="NM_001181326.1:1..1644" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:20424846]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0061091 regulation of phospholipid translocation [PMID:27033517]" /experiment="EXISTENCE:mutant phenotype:GO:0015931 nucleobase-containing compound transport [PMID:20424846]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:27033517]" /note="Protein involved in resistance to nitrosoguanidine and 6-azauracil; expression is regulated by transcription factors involved in multidrug resistance; SNG1 has a paralog, YJR015W, that arose from the whole genome duplication" /db_xref="GeneID:853111" /db_xref="SGD:S000003429" ORIGIN 1 mtksvgdees qyiedpsfaa aaaftggrdg vsysnqrfae gsghssdlak sledyrppde 61 kpsslssvge gganeeekgg ndggplariq tglfsprlrn hrkkilskfv lnnffiacvc 121 vslisiywga cygtdryffk vknivvlqda psntsvqsis aiipsllasv pgtwhiynat 181 sfhrkfgttn steidrkivd liyderywla lnvkpnatdt lynslisqda nsefnssiff 241 esvfesgrdp ssvkstilpl mqqlevrlqk yyvkeylpsl msnitsndrd lninmenwai 301 agqllftynd yrpfadrilm aplqvgliyc illtvlqlsl ygklhgemar vlkpkhiliy 361 rlliswatyf llsigfctvs aifridftpa fgrggfvvyw mstwlvmmav gganenvlsl 421 viaycppyls iwlmtwiiln isasfypmvl nnefyrygyi mpihnavdiy kviflnltkr 481 kmgrnygilv awvalntslm pfcmkfagkk mqknamqaae aavaaatqra srpaeantdk 541 nnnppgn // LOCUS NP_011714 817 aa linear PLN 30-JUN-2025 DEFINITION Ypp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011714 VERSION NP_011714.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181327.3 REFERENCE 1 (residues 1 to 817) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 817) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 817) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 817) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08291. On Jul 30, 2012 this sequence version replaced NP_011714.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..817 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..817 /product="Ypp1p" /calculated_mol_wt="95235" Region 18..815 /region_name="YPP1" /note="cargo-transport protein YPP1; cd23270" /db_xref="CDD:438014" Region 41..80 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" Region 95..129 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" Region 136..175 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" Region 239..282 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" Region 291..335 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" Region 336..374 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" Region 473..517 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" Region 525..559 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" Region 568..608 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" Region 627..660 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" Region 683..715 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:438014" CDS 1..817 /gene="YPP1" /locus_tag="YGR198W" /coded_by="NM_001181327.3:1..2454" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:17576801]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:17576801]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19075114|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0006623 protein targeting to vacuole [PMID:17576801]" /experiment="EXISTENCE:direct assay:GO:0006898 receptor-mediated endocytosis [PMID:17576801]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:17576801]" /experiment="EXISTENCE:direct assay:GO:0072659 protein localization to plasma membrane [PMID:19075114]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:17576801]" /note="Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4p; is required, along with Efr3p, for the assembly and recruitment of multiple copies of the kinase into phosphoinositide kinase (PIK) patches at the plasma membrane; positively regulates Stt4p; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene" /db_xref="GeneID:853112" /db_xref="SGD:S000003430" ORIGIN 1 mpnsnvripp tvpskiidvv dqalrarllg gstfnsgfds ldsvlnlqfr lhyhvigsng 61 pakpvcdvll kesqnleknm smmeelndyp eitklvekil fnclgilffh rgqfqesqrc 121 llhslkihnn tasqktalme qydryliven lyyrglvsqd inimqnvfyk ellahvdtip 181 pesngllfey islivaklrf nqiqdlaenf kttvenpfil flymikkfqs plkkhidndd 241 lylkfgqnvl lkakfptase tndealehfn vflqyyfkft hikkikvnps wynfiissme 301 ktfqsievsk tamflfqnls dnsndeikkk tfkresilnf vnfvkyndky yqlhdnshrd 361 iisfidaysf ilqnssktds ienvfdydnt vstfatslns fykeynlplm sqsesldwle 421 nstrcvypgn iskvltnaws tlyeirkyql dflvsnnlts ylcnammlst kekdnadvee 481 qeegeeekal relqfkysyt laqqrhieta iktleslils knpnyykawh llalcrsvqe 541 dkemsykivc svleamnesl qnntlllndr wqfihlkltq lalieeifgt lealetlpev 601 felyatlfpd sqpelnsmgp kysqtkeyll qmvwifaanm ymrtkdnded akaaikeasn 661 veskfknlnc niangylsii kdepgvalke fetvlyyden nldalvgfae lifpeelgve 721 etnleryytl sldkkpgkra kltfvndtdr saayarlkfl lecailesie ayyspevwwy 781 lsliyekyqd deyknsllkc ikyqelnpir slrycny // LOCUS NP_011715 759 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011715 VERSION NP_011715.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181328.1 REFERENCE 1 (residues 1 to 759) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 759) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 759) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 759) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08292. Method: conceptual translation. FEATURES Location/Qualifiers source 1..759 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..759 /product="dolichyl-phosphate-mannose-protein mannosyltransferase PMT6" /EC_number="2.4.1.109" /calculated_mol_wt="87895" Region 71..314 /region_name="PMT" /note="Dolichyl-phosphate-mannose-protein mannosyltransferase; pfam02366" /db_xref="CDD:396786" Region 340..542 /region_name="beta-trefoil_MIR_PMT2-like" /note="MIR domain, beta-trefoil fold, found in Saccharomyces cerevisiae dolichyl-phosphate-mannose--protein mannosyltransferase 2 (PMT2) and similar proteins; cd23284" /db_xref="CDD:467755" Site 404 /site_type="glycosylation" /note="glycosylation site [posttranslational modification]" /db_xref="CDD:467755" Site 516 /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467755" Region 560..753 /region_name="PMT_4TMC" /note="C-terminal four TMM region of protein-O-mannosyltransferase; pfam16192" /db_xref="CDD:465056" CDS 1..759 /gene="PMT6" /locus_tag="YGR199W" /coded_by="NM_001181328.1:1..2280" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006493 protein O-linked glycosylation [PMID:9184828]" /experiment="EXISTENCE:mutant phenotype:GO:0035269 protein O-linked mannosylation [PMID:18182384]" /note="Protein O-mannosyltransferase; transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases" /db_xref="GeneID:853113" /db_xref="SGD:S000003431" ORIGIN 1 mskakgtgfs sidtedenlr eryvnqpkan asdiqdeqld cfeqleekhr tkkneeytal 61 kilrdvigpl lltitsfylr fqhidqnnyv vwdeahfgkf gsyyikheyy hdvhpplgkm 121 lialsewmag fdgqfdfssn naypenvnfk lmrqfnatfg alctpvafft akwmgfnyft 181 vyliatmvtl ehsyivlskf illdsmllff smttfacmik lytlrkqqmt kkwslwmllt 241 glsigcvcsv kwvglfitvv vglytcielf llycdkelpr ikyykhwlir iinlivipfl 301 iylycfkihf vllyksgtgd sttntlfqin legtqieagp rdvafgselt irshglspnl 361 lhshiqvype gsgqrqitgy gfadsnnvwk fefsrssgle ldqngtlngk iipitdgvev 421 rlshkntgsn lhshdvpshv srgnyevsgy gsqsvgdekd dwiveivkqm dspnpvysne 481 nstilhpvst ffrlrhkvlg cylastglty pawgfkqaei vckdswsrrd kstwwnvedh 541 wnhnletaed yvppksnfwt dfiltnfama ssnnalvpde dkydslssda wewptlhkgl 601 rmcswagyit ryylmgspfn twistvslii fpfiilfily rwrrqtlyls ddqiwqitiq 661 gifpfiswmt hylpfammgr vtyvhhyvpa lyfamlvfgf vldftltrvh wmvkypiyls 721 lfggciyiyn lfapicqgmh gdkaeylplq wlstwdiap // LOCUS NP_011716 788 aa linear PLN 30-JUN-2025 DEFINITION Elongator subunit ELP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011716 VERSION NP_011716.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181329.3 REFERENCE 1 (residues 1 to 788) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 788) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 788) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 788) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08293. On Jul 30, 2012 this sequence version replaced NP_011716.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..788 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..788 /product="Elongator subunit ELP2" /calculated_mol_wt="89280" Region 52..413 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(58,76,80,86,90,102,118,123,129,132,149..150,169,174, 180..181,201,222,227,233..234,279..280,298,302,308..309, 336..337,355,358,364..365,383..384,402,406,412..413) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 62..102 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 108..144 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 153..199 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 206..264 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 274..733 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 284..322 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 341..382 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 388..412 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 443..534 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 561..604 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 610..651 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 656..698 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 705..746 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..788 /gene="ELP2" /locus_tag="YGR200C" /gene_synonym="KTI3; TOT2" /coded_by="NM_001181329.3:1..2367" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:25960406]" /experiment="EXISTENCE:direct assay:GO:0033588 elongator holoenzyme complex [PMID:11689709]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11689709]" /experiment="EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14551258]" /note="Subunit of Elongator complex; binds to microtubules via conserved alkaline residues; has two seven-bladed WD40 beta propellers; Elongator complex is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin" /db_xref="GeneID:853114" /db_xref="SGD:S000003432" ORIGIN 1 mvecitpeai figankqtqv sdihkvkkiv afgagktial wdpiepnnkg vyatlkghea 61 evtcvrfvpd sdfmvsased hhvkiwkftd yshlqciqti qhysktival salpslisvg 121 cadgtisiwr qniqndefgl aheftikkgf fyplclslsk veekkyllai ggtnvnvfia 181 sfilsdsgie kcrvvaeleg hedwvkslaf rhqetpgdyl lcsgsqdryi rlwririndl 241 iddseedskk ltllsnkqyk fqiddelrvg infealimgh ddwisslqwh esrlqllaat 301 adtslmvwep detsgiwvcs lrlgemsskg astatgssgg fwsclwfthe rmdffltngk 361 tgswrmwatk dniicdqrlg isgatkdvtd iawspsgeyl latsldqttr lfapwiydas 421 grkreiatwh efsrpqihgy dmicvetvtd trfvsggdek ilrsfdlpkg vagmlqkfvg 481 iqfeeksemp dsatvpvlgl snkageddan eddeeeeggn ketpditdpl sllecppmed 541 qlqrhllwpe veklyghgfe itcldispdq kliasacrsn nvqnavirif stenwleikp 601 alpfhsltit rlkfskdgkf llsvcrdrkw alwernmedn tfelrfknek phtriiwdad 661 waplefgnvf vtasrdktvk vwrhqkepad dyvleasikh tkavtaisih dsmirekili 721 svglengeiy lysytlgkfe litqlnedit padkitrlrw shlkrngklf lgvgssdlst 781 riyslaye // LOCUS NP_011717 225 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR201C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011717 VERSION NP_011717.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181330.3 REFERENCE 1 (residues 1 to 225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 225) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08294. On Jul 30, 2012 this sequence version replaced NP_011717.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..225 /product="uncharacterized protein" /calculated_mol_wt="26166" Region 4..78 /region_name="Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold" /note="The thioredoxin (TRX)-like superfamily is a large, diverse group of proteins containing a TRX fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox...; cl00388" /db_xref="CDD:469754" Region 98..220 /region_name="GST_C_EF1Bgamma_like" /note="Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins; cd03181" /db_xref="CDD:198290" Site order(102..103,106..107,110,147) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:198290" Site order(109,173,177,206,209..211) /site_type="other" /note="N-terminal domain interface [polypeptide binding]" /db_xref="CDD:198290" CDS 1..225 /locus_tag="YGR201C" /coded_by="NM_001181330.3:1..678" /note="hypothetical protein" /db_xref="GeneID:853115" /db_xref="SGD:S000003433" ORIGIN 1 msdgtlftdl kerklirtiv prglvrslkl dvkladpsda qqlyerefpl rkyptfvgph 61 dewtlteama idyylihlss dkeavrqllg pegdfktrad ilrweslsns dflnevcevf 121 fpligvkpyn atefkaaren vdtivslyek rlkkqqylvc ddhetladli saaafslgfi 181 sffdetwrsk hpevtrwfnr viksrffege fesfkmcete mqpik // LOCUS NP_011718 424 aa linear PLN 30-JUN-2025 DEFINITION choline-phosphate cytidylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011718 VERSION NP_011718.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181331.1 REFERENCE 1 (residues 1 to 424) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 424) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 424) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 424) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08295. Method: conceptual translation. FEATURES Location/Qualifiers source 1..424 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..424 /product="choline-phosphate cytidylyltransferase" /EC_number="2.7.7.15" /calculated_mol_wt="49275" Region 102..251 /region_name="CCT" /note="CTP:phosphocholine cytidylyltransferase; cd02174" /db_xref="CDD:173925" Site order(109..112,116,118..119,122,140,149,177..178,195..196, 209,222..224,227) /site_type="active" /db_xref="CDD:173925" Site 116..119 /site_type="other" /note="(T/H)XGH motif" /db_xref="CDD:173925" CDS 1..424 /gene="PCT1" /locus_tag="YGR202C" /gene_synonym="BSR2; CCT1" /coded_by="NM_001181331.1:1..1275" /experiment="EXISTENCE:direct assay:GO:0004105 choline-phosphate cytidylyltransferase activity [PMID:2826147]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12200438]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:12200438]" /experiment="EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:10397762]" /experiment="EXISTENCE:direct assay:GO:0006657 CDP-choline pathway [PMID:10397762]" /experiment="EXISTENCE:direct assay:GO:0042564 NLS-dependent protein nuclear import complex [PMID:19141610]" /note="Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; controls phosphatidylcholine homeostasis; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity" /db_xref="GeneID:853116" /db_xref="SGD:S000003434" ORIGIN 1 manpttgkss iraklsnssl snlfkknknk rqreeteeqd nedkdesknq denkdtqltp 61 rkrrrltkef eekearytne lpkelrkyrp kgfrfnlppt drpiriyadg vfdlfhlghm 121 kqleqckkaf pnvtlivgvp sdkithklkg ltvltdkqrc etlthcrwvd evvpnapwcv 181 tpefllehki dyvahddipy vsadsddiyk pikemgkflt tqrtngvsts diitkiirdy 241 dkylmrnfar gatrqelnvs wlkknelefk khinefrsyf kknqtnlnna srdlyfevre 301 illkktlgkk lysklignel kkqnqrqrkq nflddpftrk lireaspate faneftgens 361 takspddngn lfsqeddedt nsnntntnsd sdsntnstpp seddddndrl tlenltqkkk 421 qsan // LOCUS NP_011719 148 aa linear PLN 30-JUN-2025 DEFINITION phosphatase YCH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011719 VERSION NP_011719.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181332.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08296. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..148 /product="phosphatase YCH1" /calculated_mol_wt="17117" Region 9..132 /region_name="Acr2p" /note="Eukaryotic arsenate resistance proteins are members of the Rhodanese Homology Domain superfamily. Included in this CD is the Saccharomyces cerevisiae arsenate reductase protein, Acr2p, and other yeast and plant homologs; cd01531" /db_xref="CDD:238789" Site 90..96 /site_type="active" /db_xref="CDD:238789" CDS 1..148 /gene="YCH1" /locus_tag="YGR203W" /coded_by="NM_001181332.1:1..447" /experiment="EXISTENCE:direct assay:GO:0004792 thiosulfate-cyanide sulfurtransferase activity [PMID:19864628]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016311 dephosphorylation [PMID:19382206]" /experiment="EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:19382206]" /note="Phosphatase with sequence similarity to Mih1p; member of the Cdc25p subfamily of tyrosine phosphatases and Arr2p, an arsenate reductase, based on the presence of a rhodanese-homology domain; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /db_xref="GeneID:853117" /db_xref="SGD:S000003435" ORIGIN 1 mdsysitnvk yldptelhrw mqeghtttlr epfqvvdvrg sdymgghikd gwhyaysrlk 61 qdpeylrelk hrllekqadg rgalnvifhc mlsqqrgpsa amlllrsldt aelsrcrlwv 121 lrggfsrwqs vygddesvta gylpdlwr // LOCUS NP_011720 946 aa linear PLN 30-JUN-2025 DEFINITION trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011720 VERSION NP_011720.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181333.3 REFERENCE 1 (residues 1 to 946) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 946) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 946) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 946) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08297. On Jul 30, 2012 this sequence version replaced NP_011720.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..946 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..946 /product="trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /EC_number="6.3.4.3" /calculated_mol_wt="102074" Region 1..303 /region_name="FolD" /note="5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]; COG0190" /db_xref="CDD:439960" Region 322..946 /region_name="FTHFS" /note="Formate--tetrahydrofolate ligase; pfam01268" /db_xref="CDD:460143" CDS 1..946 /gene="ADE3" /locus_tag="YGR204W" /coded_by="NM_001181333.3:1..2841" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004329 formate-tetrahydrofolate ligase activity [PMID:8464869]" /experiment="EXISTENCE:mutant phenotype:GO:0004477 methenyltetrahydrofolate cyclohydrolase activity [PMID:8464869]" /experiment="EXISTENCE:mutant phenotype:GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity [PMID:8464869]" /experiment="EXISTENCE:mutant phenotype:GO:0006760 folic acid-containing compound metabolic process [PMID:5563870]" /experiment="EXISTENCE:mutant phenotype:GO:0009113 purine nucleobase biosynthetic process [PMID:8464869]" /note="Cytoplasmic trifunctional enzyme; catalyzes sequential reactions 10-formyl-THF synthetase (EC 6.3.4.3), 5,10-methenyl-THF cyclohydrolase (EC 3.5.4.9), and 5,10-methylene-THF dehydrogenase (EC 1.5.1.5), to supply forms of activated one-carbon units required for biosynthesis of purines, histidine, methionine, pantothenic acid, the formyl group of mitochondrial fMet-tRNAfMet, and the methyl group of thymidylate; null mutation causes auxotrophy for adenine and histidine in rich medium" /db_xref="GeneID:853118" /db_xref="SGD:S000003436" ORIGIN 1 magqvldgka caqqfrsnia neiksiqghv pgfapnlaii qvgnrpdsat yvrmkrkaae 61 eagivanfih ldesatefev lryvdqlned phthgiivql plpahldedr itsrvlaekd 121 vdgfgptnig elnkknghpf flpctpkgii ellhkanvti egsrsvvigr sdivgspvae 181 llkslnstvt ithsktrdia sylhdadivv vaigqpefvk gewfkprdgt ssdkktvvid 241 vgtnyvadps kksgfkcvgd vefneaikyv hlitpvpggv gpmtvamlmq ntliaakrqm 301 eesskplqip plplklltpv psdidisraq qpklinqlaq elgiyshele lyghykakis 361 pkvierlqtr qngkyilvsg itptplgegk stttmglvqa ltahlgkpai anvrqpslgp 421 tlgvkggaag ggysqvipmd efnlhltgdi haigaannll aaaidtrmfh ettqkndatf 481 ynrlvprkng krkftpsmqr rlnrlgiqkt npddltpeei nkfarlnidp dtitikrvvd 541 indrmlrqit igqapteknh trvtgfditv aselmailal skdlrdmker igrvvvaadv 601 nrspvtvedv gctgaltall rdaikpnlmq tlegtpvlvh agpfanisig assviadrva 661 lklvgtepea kteagyvvte agfdftmgge rffnikcrss gltpnavvlv atvralkshg 721 gapdvkpgqp lpsayteeni efvekgaanm ckqianikqf gvpvvvaink fetdtegeia 781 airkaaleag afeavtsnhw aeggkgaidl akavieasnq pvdfhflydv nssvedkltt 841 ivqkmyggaa idilpeaqrk idmykeqgfg nlpiciaktq yslshdatlk gvptgftfpi 901 rdvrlsngag ylyalaaeiq tipglatyag ymavevdddg eidglf // LOCUS NP_878082 37 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR204C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878082 VERSION NP_878082.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184596.1 REFERENCE 1 (residues 1 to 37) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 37) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 37) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 37) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 37) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 37) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 37) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 37) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08298. Method: conceptual translation. FEATURES Location/Qualifiers source 1..37 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..37 /product="uncharacterized protein" /calculated_mol_wt="4407" CDS 1..37 /locus_tag="YGR204C-A" /coded_by="NM_001184596.1:1..114" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466462" /db_xref="SGD:S000028640" ORIGIN 1 mqwnafsfvs yvylryfisf rpnivlasvr lswysii // LOCUS NP_011721 290 aa linear PLN 30-JUN-2025 DEFINITION putative ATP-dependent kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011721 VERSION NP_011721.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181334.3 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08299. On Jul 30, 2012 this sequence version replaced NP_011721.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..290 /product="putative ATP-dependent kinase" /calculated_mol_wt="33206" Region <24..281 /region_name="NK" /note="Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; cl17190" /db_xref="CDD:450170" Site order(38,43..46) /site_type="active" /db_xref="CDD:238977" CDS 1..290 /gene="TDA10" /locus_tag="YGR205W" /coded_by="NM_001181334.3:1..873" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:14997573]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /note="ATP-binding hypothetical protein; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele" /db_xref="GeneID:853119" /db_xref="SGD:S000003437" ORIGIN 1 mcdksktvld ytiefldkyi pewfetgnkc plfiffsgpq gsgksftsiq iynhlmekyg 61 geksigyasi ddfylthedq lklneqfknn kllqgrglpg thdmkllqev lntifnnneh 121 pdqdtvvlpk ydksqfkgeg drcptgqkik lpvdifileg wflgfnpilq gienndlltg 181 dmvdvnaklf fysdllwrnp eikslgivft tdninnvygw rlqqehelis kvgkgmtdeq 241 vhafvdrymp syklylndfv rseslgsiat ltlgidsnrn vystktrcie // LOCUS NP_011722 101 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-binding ESCRT-I subunit protein MVB12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011722 VERSION NP_011722.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181335.3 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08300. On Jul 30, 2012 this sequence version replaced NP_011722.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..101 /product="ubiquitin-binding ESCRT-I subunit protein MVB12" /calculated_mol_wt="11837" Region 9..98 /region_name="Mvb12" /note="ESCRT-I subunit Mvb12; pfam09452" /db_xref="CDD:370502" CDS 1..101 /gene="MVB12" /locus_tag="YGR206W" /coded_by="NM_001181335.3:1..306" /experiment="EXISTENCE:direct assay:GO:0000813 ESCRT I complex [PMID:17145965|PMID:17135292]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:17135292|PMID:14562095|PMID:17145965]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:17145965]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:19380877]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:17135292|PMID:17145965]" /experiment="EXISTENCE:mutant phenotype:GO:0031333 negative regulation of protein-containing complex assembly [PMID:17145965]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0000813 ESCRT I complex [PMID:17145965|PMID:17135292]" /note="ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers; the ESCRT-I core complex (Stp22p, Vps28p, Srn2p) is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin" /db_xref="GeneID:853120" /db_xref="SGD:S000003438" ORIGIN 1 mnnnveellr riplynkygk dfpqetvtrf qmpefklpal qptrdllcpw yeecdnitkv 61 cqlhdssnkk fdqwykeqyl skkppgivgn tllspsrkdn s // LOCUS NP_011723 261 aa linear PLN 30-JUN-2025 DEFINITION Cir1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011723 VERSION NP_011723.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181336.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08301. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..261 /product="Cir1p" /calculated_mol_wt="28628" Region 7..216 /region_name="ETF_beta" /note="electron transfer flavoprotein (ETF) beta; cd01714" /db_xref="CDD:467487" CDS 1..261 /gene="CIR1" /locus_tag="YGR207C" /coded_by="NM_001181336.1:1..786" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]" /note="Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response" /db_xref="GeneID:853121" /db_xref="SGD:S000003439" ORIGIN 1 msakqqlril vpvkrvvdfq ikprvnktlt gietsgikfs inpfddiave eairikeknk 61 slvesthavs igsakaqdil rnclakgidt cslidsvgke nieplaiaki lkavvekkgs 121 nlvlmgkqai dddcnntgqm lagllnwpqa tnaakvefld ngrvqvtrei ddgeevieas 181 lpmvittdlr lntpryvglp klmkakkkpi ekldiakdfp einiepqlki vsmeepktks 241 pgvklnsvde lieklkevka i // LOCUS NP_011724 309 aa linear PLN 30-JUN-2025 DEFINITION phosphoserine phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011724 VERSION NP_011724.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181337.1 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08302. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..309 /product="phosphoserine phosphatase" /EC_number="3.1.3.3" /calculated_mol_wt="34076" Region 78..298 /region_name="serB" /note="phosphoserine phosphatase SerB; TIGR00338" /db_xref="CDD:273022" Site order(97..101,186..188,232,254..255,258..259) /site_type="active" /db_xref="CDD:319803" CDS 1..309 /gene="SER2" /locus_tag="YGR208W" /coded_by="NM_001181337.1:1..930" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006564 L-serine biosynthetic process [PMID:1326413]" /experiment="EXISTENCE:mutant phenotype:GO:0036424 L-phosphoserine phosphatase activity [PMID:1326413]" /note="Phosphoserine phosphatase of the phosphoglycerate pathway; involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source" /db_xref="GeneID:853122" /db_xref="SGD:S000003440" ORIGIN 1 mskfvitcia hgenlpketi dqiakeites sakdvsingt kklsaratdi fievagsivq 61 kdlknkltnv idshndvdvi vsvdneyrqa kklfvfdmds tliyqeviel iaayagveeq 121 vheiteramn neldfkeslr ervkllqglq vdtlydeikq klevtkgvpe lckflhkknc 181 klavlsggfi qfagfikdql gldfckanll evdtdgkltg ktlgpivdgq cksetllqlc 241 ndynvpveas cmvgdggndl pamatagfgi awnakpkvqk aapcklntks mtdilyilgy 301 tddeiynrq // LOCUS NP_011725 104 aa linear PLN 30-JUN-2025 DEFINITION thioredoxin TRX2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011725 VERSION NP_011725.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181338.3 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08303. On Jul 30, 2012 this sequence version replaced NP_011725.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..104 /product="thioredoxin TRX2" /calculated_mol_wt="11073" Region 6..104 /region_name="thioredoxin" /note="TIGR01068" /db_xref="CDD:200072" Site order(31,34) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239245" CDS 1..104 /gene="TRX2" /locus_tag="YGR209C" /gene_synonym="LMA1" /coded_by="NM_001181338.3:1..315" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8603912]" /experiment="EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9813082]" /experiment="EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9813082]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:9657146]" /experiment="EXISTENCE:direct assay:GO:0080058 protein deglutathionylation [PMID:20074363]" /experiment="EXISTENCE:genetic interaction:GO:0000103 sulfate assimilation [PMID:2026619]" /experiment="EXISTENCE:genetic interaction:GO:0006749 glutathione metabolic process [PMID:23242256]" /experiment="EXISTENCE:genetic interaction:GO:0045454 cell redox homeostasis [PMID:22561702]" /experiment="EXISTENCE:genetic interaction:GO:0080058 protein deglutathionylation [PMID:20074363]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:8603912|PMID:9015301]" /experiment="EXISTENCE:mutant phenotype:GO:0080058 protein deglutathionylation [PMID:27708136]" /note="Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system that protects cells from oxidative and reductive stress; subunit of the LMA1 complex, with Pbi2p, that promotes vacuole inheritance; cofactor for Tsa1p; required for ER-Golgi transport; facilitates mitochondrial import of small Tims (Tim9p, Tim10p, Tim13p) by maintaining them in reduced form along with Trx1p; component of a signal transduction redox relay in a light sensing pathway; abundance increases under DNA replication stress" /db_xref="GeneID:853123" /db_xref="SGD:S000003441" ORIGIN 1 mvtqlksase ydsalasgdk lvvvdffatw cgpckmiapm iekfaeqysd aafykldvde 61 vsdvaqkaev ssmptlifyk ggkevtrvvg anpaaikqai asnv // LOCUS NP_011726 411 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR210C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011726 VERSION NP_011726.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181339.1 REFERENCE 1 (residues 1 to 411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 411) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08304. Method: conceptual translation. FEATURES Location/Qualifiers source 1..411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..411 /product="uncharacterized protein" /calculated_mol_wt="45083" Region 7..329 /region_name="Ygr210" /note="Ygr210 GTPase; cd01899" /db_xref="CDD:206686" Site 11..18 /site_type="other" /note="G1 box" /db_xref="CDD:206686" Site order(14,16..19,228..229,231,255..257) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206686" Site order(26..29,31..41) /site_type="other" /note="Switch I region" /db_xref="CDD:206686" Site 38 /site_type="other" /note="G2 box" /db_xref="CDD:206686" Site 82..107 /site_type="other" /note="Switch II region" /db_xref="CDD:206686" Site 83..86 /site_type="other" /note="G3 box" /db_xref="CDD:206686" Site 228..231 /site_type="other" /note="G4 box" /db_xref="CDD:206686" Site 255..257 /site_type="other" /note="G5 box" /db_xref="CDD:206686" Region 329..405 /region_name="TGS_Obg" /note="TGS (ThrRS, GTPase and SpoT) domain found in the Obg protein family; cd04938" /db_xref="CDD:340517" CDS 1..411 /locus_tag="YGR210C" /coded_by="NM_001181339.1:1..1236" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:853124" /db_xref="SGD:S000003442" ORIGIN 1 mprdpligiv gkpssgkstt lnsltdagaa vgafpfttie pnqatgylqv ecacsrfgke 61 dlckpnygwc skgkrhipik lldvaglvpg ahsgrglgnk flddlrhada lihvvdvsgt 121 tdaegkntrg ydplndiewl qdeirlwveg nlkkrwgsiv rkhtatkssi vdtlqaqfgg 181 ygshapmiqk aldrlkglpp lekwddewit rvvksfmmek fptvlalnki dhpdadknvs 241 kimlkypdtk avltsavtev flrklkkqgf ilyeegtefv dtfedepdkl kplddkilnr 301 ienirdlvly rfgstgvvqv lqaatdilgl ipvytvkniq tftggngtnv frdcflvkrg 361 tpvgkvaryi mggevtiasi etvggvrvse eslvepgknd ilgfkiaprs a // LOCUS NP_011727 486 aa linear PLN 30-JUN-2025 DEFINITION zinc finger-containing protein ZPR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011727 VERSION NP_011727.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181340.3 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08305. On Jul 30, 2012 this sequence version replaced NP_011727.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..486 /product="zinc finger-containing protein ZPR1" /calculated_mol_wt="54941" Region 52..210 /region_name="zf-ZPR1" /note="ZPR1 zinc-finger domain; pfam03367" /db_xref="CDD:427263" Region 293..486 /region_name="ZPR1_znf" /note="ZPR1 zinc finger domain; TIGR00310" /db_xref="CDD:273007" CDS 1..486 /gene="ZPR1" /locus_tag="YGR211W" /coded_by="NM_001181340.3:1..1461" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9852145|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:9852145]" /experiment="EXISTENCE:direct assay:GO:0061770 translation elongation factor binding [PMID:9852145]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:9852145]" /experiment="EXISTENCE:mutant phenotype:GO:0006458 'de novo' protein folding [PMID:36630955]" /experiment="EXISTENCE:mutant phenotype:GO:0044183 protein folding chaperone [PMID:36630955]" /note="Chaperone with two zinc fingers essential for eEF1A biogenesis; nuclear in growing cells, cytoplasmic in starved cells; shuttled via process mediated by Cpr1p; binds translation elongation factor eEF-1 (Tef1p); relative distribution to nucleus increases upon DNA replication stress; human ZPR1 gene can complement yeast by allowing growth during down-regulation of yeast zpr1" /db_xref="GeneID:853125" /db_xref="SGD:S000003443" ORIGIN 1 mseqkedlfk pvgeaaaeve desiaeqnka ndgvkltgaq damghpvqei eslcmncgkn 61 gttrllltsi pyfreiiims fdcphcgfkn ceiqpasqiq ekgsryvlkv ecredfnrqv 121 iksetatckf veldieipak rgqlttvegl lsemiddlsq dqemrkside alykkiddfi 181 qkvksyince pntipitfil ddpagnswie ykpgepqhkw shtqyvrtde qnvqvgiitr 241 dqleqrrqeq lkqlanrern psesvkvgsa npqflsdatd ienfnnevqt frascpsctq 301 ecethmkpvn iphfkeviim stvcdhcgyk snevktggai pdkgrritly cddaadlsrd 361 ilksetcsmv ipelhldiqe gtlggrfttl egllrqvyee lesriftqts dsmdeatkar 421 wveffaklke aiagkvkftv imedplagsy iqnvyapdpd pnmtiedyer tkeqnedlgl 481 sdikve // LOCUS NP_011728 468 aa linear PLN 30-JUN-2025 DEFINITION N-acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011728 VERSION NP_011728.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181341.3 REFERENCE 1 (residues 1 to 468) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 468) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 468) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 468) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08306. On Jul 30, 2012 this sequence version replaced NP_011728.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..468 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..468 /product="N-acetyltransferase" /calculated_mol_wt="54342" Region 4..447 /region_name="Condensation" /note="Condensation domain; cl23853" /db_xref="CDD:420054" CDS 1..468 /gene="SLI1" /locus_tag="YGR212W" /coded_by="NM_001181341.3:1..1407" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15025559]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15025559]" /experiment="EXISTENCE:direct assay:GO:0008080 N-acetyltransferase activity [PMID:15025559]" /experiment="EXISTENCE:direct assay:GO:0009410 response to xenobiotic stimulus [PMID:15025559]" /experiment="EXISTENCE:mutant phenotype:GO:0008080 N-acetyltransferase activity [PMID:15025559]" /note="N-acetyltransferase; confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin" /db_xref="GeneID:853126" /db_xref="SGD:S000003444" ORIGIN 1 mnlklsaies yffhrsrlnl hscfyvgikl nelpkksqli aalkytviqh erltcnvfyd 61 elkkenflqn ileplkfcdl veyrhdwdql geteinhifq rynfsynenk plwkililpn 121 qnqmllltdh vlmdgmsaih vwetfmeglq mqqpveidet iyspslnsst ekimsaplyg 181 dwpipwnwhi vrqlvsrlhy wfpqtvvknn rnliqfanys fpkdllddkp sdgtqkykvk 241 ntnhqwefrl spthlndilq eckanntslt sllgalvcts fekiaaheyt gsflkielpm 301 nirkpfervl klpsddklav gnfiaviefn hklhqnrgiw diasqiqrai rsssedkiid 361 kvnevkllev issqqyiedk islnngpsst fevtnlgfqt fkdacntslp fyivdatfne 421 pqgissifsl svistpgngl hccisypntl tkvlephwqy mkdylnly // LOCUS NP_011729 317 aa linear PLN 30-JUN-2025 DEFINITION Rta1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011729 VERSION NP_011729.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181342.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08307. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..317 /product="Rta1p" /calculated_mol_wt="35355" Region 72..275 /region_name="RTA1" /note="RTA1 like protein; pfam04479" /db_xref="CDD:461325" CDS 1..317 /gene="RTA1" /locus_tag="YGR213C" /coded_by="NM_001181342.1:1..954" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22129104]" /note="Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein; RTA1 has a paralog, YLR046C, that arose from the whole genome duplication" /db_xref="GeneID:853127" /db_xref="SGD:S000003445" ORIGIN 1 makdgfelyr ytpelgasil ftvlfavsgv afvillfhys vkskrrvgsl mksqpvlryy 61 gtvnlagayi pfifgcfvec vgfafrckss kdttllnpyi iqtvfllvsp tlyaasiymi 121 fgrmatllfa enlmimparf nttifvigdv gslllqaigg ammskvtsas sgshlvtagl 181 fiqiaffglf iinevlfifk mskkptnvsv rygswkylni allvnsflil irsivravef 241 iqgydgeias hewylyifdg lpmfllvlif ivafplinif riheesiqaq qsarfdgtdy 301 pdvevtsiee dlaskse // LOCUS NP_011730 252 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS2 RPS0A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011730 VERSION NP_011730.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181343.1 REFERENCE 1 (residues 1 to 252) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 252) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 252) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 252) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08308. Method: conceptual translation. FEATURES Location/Qualifiers source 1..252 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..252 /product="40S ribosomal protein uS2 RPS0A" /calculated_mol_wt="27893" Region 1..252 /region_name="PTZ00254" /note="40S ribosomal protein SA; Provisional" /db_xref="CDD:240331" CDS 1..252 /gene="RPS0A" /locus_tag="YGR214W" /gene_synonym="NAB1; NAB1A; YST1" /coded_by="NM_001181343.1:1..759" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:8626693]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:8626693]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:8626693]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /experiment="EXISTENCE:mutant phenotype:GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:9973221|PMID:8626693]" /note="Ribosomal 40S subunit protein S0A; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2; RPS0A has a paralog, RPS0B, that arose from the whole genome duplication" /db_xref="GeneID:853128" /db_xref="SGD:S000003446" ORIGIN 1 mslpatfdlt pedaqlllaa nthlgarnvq vhqepyvfna rpdgvhvinv gktweklvla 61 ariiaaipnp edvvaissrt fgqravlkfa ahtgatpiag rftpgsftny itrsfkeprl 121 vivtdprsda qaikeasyvn ipvialtdld spsefvdvai pcnnrgkhsi gliwyllare 181 vlrlrgalvd rtqpwsimpd lyfyrdpeev eqqvaeeatt eeageeeake evteeqaeat 241 ewaeenadnv ew // LOCUS NP_011731 110 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS33 RSM27 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011731 VERSION NP_011731.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181344.3 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08309. On Jul 30, 2012 this sequence version replaced NP_011731.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..110 /product="mitochondrial 37S ribosomal protein mS33 RSM27" /calculated_mol_wt="12261" Region 6..93 /region_name="MRP-S33" /note="Mitochondrial ribosomal subunit S27; pfam08293" /db_xref="CDD:462417" CDS 1..110 /gene="RSM27" /locus_tag="YGR215W" /gene_synonym="mS33" /coded_by="NM_001181344.3:1..333" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:853129" /db_xref="SGD:S000003447" ORIGIN 1 mnvpkarllk vaelsakifd qnfnpsgirt gskilnerlk gpsvasyygn pdilkfrhlk 61 tlypdiefvd leeqyrlsmv eakkrrgkga pkkmkkdaaa takgkgkkkk // LOCUS NP_011732 609 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol N-acetylglucosaminyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011732 VERSION NP_011732.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181345.1 REFERENCE 1 (residues 1 to 609) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 609) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 609) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 609) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08310. Method: conceptual translation. FEATURES Location/Qualifiers source 1..609 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..609 /product="phosphatidylinositol N-acetylglucosaminyltransferase" /EC_number="2.4.1.198" /calculated_mol_wt="70224" Region 220..517 /region_name="Gpi1" /note="N-acetylglucosaminyl transferase component (Gpi1); pfam05024" /db_xref="CDD:461527" CDS 1..609 /gene="GPI1" /locus_tag="YGR216C" /coded_by="NM_001181345.1:1..1830" /experiment="EXISTENCE:curator inference:GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity [PMID:9729469]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006506 GPI anchor biosynthetic process [PMID:8910381]" /experiment="EXISTENCE:genetic interaction:GO:0000506 glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex [PMID:9729469]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:8910381]" /note="Membrane protein involved in the synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1 are functional homologs" /db_xref="GeneID:853130" /db_xref="SGD:S000003448" ORIGIN 1 mpnyifwpye slfensaaqg pqvalaisfe kthfvvlgvc epqyleevsi rppysvvatk 61 nngaegwnyk vadpcnvhfr ipklkfmqfy ssdpisliip ekevglhssv getlnyskle 121 qhprykrdnk klsetlniin lfpayckaln elypfiqtsq enlrgtmlns vaawcsstci 181 ykmvakigfy ltfvicsias lvssllnysh fqlvnysafv qqidlrcqqi cyfpvqyeri 241 nkkdniqnvg smvekdnsns qfshsympsk fypdyillyn tiwliindis fglilgaili 301 enrdflvsas hrvlkfflyd slktitetla nnplgiklna elanflself lwviefsytt 361 fikrlidpkt lsslltltiy mmflvgfsfa vslaidffai lsfpiyvfyr issklyhcql 421 nimaslfnlf cgkkrnvlrn ridhnyfqld qlllgtllfi ilvfltptvm afymsytvlr 481 mltitieifs eavialinhf plfalllrlk dpkrlpggis ielkttvsnk httlelqnnp 541 ikfksmfrpy nlllsqmrtn yfsfatvrki vrgesimvnr nklyyvlyss lpskplsvkd 601 lykrltiqa // LOCUS NP_011733 2039 aa linear PLN 30-JUN-2025 DEFINITION calcium channel protein CCH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011733 VERSION NP_011733.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181346.3 REFERENCE 1 (residues 1 to 2039) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2039) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 2039) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2039) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2039) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2039) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2039) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 2039) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08311. On Jul 30, 2012 this sequence version replaced NP_011733.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2039 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..2039 /product="calcium channel protein CCH1" /calculated_mol_wt="234469" Region <483..722 /region_name="Ion_trans" /note="Ion transport protein; pfam00520" /db_xref="CDD:459842" Region 769..1010 /region_name="Ion_trans" /note="Ion transport protein; pfam00520" /db_xref="CDD:459842" Region 1210..1480 /region_name="Ion_trans" /note="Ion transport protein; pfam00520" /db_xref="CDD:459842" Region 1529..1776 /region_name="Ion_trans" /note="Ion transport protein; pfam00520" /db_xref="CDD:459842" CDS 1..2039 /gene="CCH1" /locus_tag="YGR217W" /coded_by="NM_001181346.3:1..6120" /experiment="EXISTENCE:direct assay:GO:0005262 calcium channel activity [PMID:10958666]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10958666]" /experiment="EXISTENCE:direct assay:GO:0006816 calcium ion transport [PMID:10958666]" /experiment="EXISTENCE:mutant phenotype:GO:0005262 calcium channel activity [PMID:9343395]" /experiment="EXISTENCE:mutant phenotype:GO:0006816 calcium ion transport [PMID:9343395]" /note="Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function" /db_xref="GeneID:853131" /db_xref="SGD:S000003449" ORIGIN 1 mqgrkrtlte pfepntnpfg dnaavmtenv ednsetdgnr leskpqalvp palnivppes 61 sihsteekkg deyngndkds slisnifrtr vgrsshenls rpklslktas fgaaessrrn 121 vspstksaks ssqyidlnde rlrrrsfssy srsssrrvsn spsstdrppr sakvlsliaa 181 ddmddfedlq kgfksaidee gltwlpqlks eksrpvsdvg edrgegeqes ipdvhtpnvg 241 asatpgsihl tpepaqngsv seglegsinn srkkpspkff hhlspqkedk dqtevieyae 301 dildfetlqr klesrpfvly ghslgvfspt nplrikiarf llhrryslly ntlltfyail 361 lairtynphn vvflyrfsnw tdyfifilsa cftgndiaki iafgfwddse mfkaygreyk 421 silqrsgimk lyiylrekyg rklidfiipf riispgeetk yqrsslstsl tkpygakenq 481 rpfgtprafa rsswnridlv ssvsfwlgmf lsiksydtkt girifkplai lrilrlvnvd 541 tgmpsilrgl kygipqlvnv ssmlvyfwif fgilgvqifq gsfrrqcvwf npedptdtyq 601 ydmqfcggyl dpvtkrkqny iyedgsegsv skgflcpqys kcvsnanpyn grisfdnivn 661 smelvfvims antftdlmyy tmdsdemaac lffivcifvl tiwllnllia vlvssfeian 721 eeykkkkfiy gsrktgyvar ivtgywkyfk lkanqtkfpn wsqkglaiys hvefifvili 781 icdigmrasv kvstsancnn illktdrgis ivlfieslar lvlylpnmwk fltkpsyvyd 841 fiisiitlvi sclavegvlg hmyawlsifh isrfyrviis fnltkklwkq ilsngvmiwn 901 lssfyffftf lvaiimavyf egvippeema dqpfgmyslp nsflslfiig stenwtdily 961 alqkhspnis stffcsvffi iwfllsnsvi lnifialise smevkeeekr pqqikhylkf 1021 vypqkiqeyt haslvarirk kffgghrned trdfkqflmr gtaimniaqn mgeladefke 1081 ppsenlfkkg lskltigvps lkrlrmfann pfyknsdvvf tetndingrt yilelneyed 1141 ekldylkkyp lfnysyyffs pqhrfrrfcq rlvppstgkr tdgsrffeds tdlynkrsyf 1201 hhierdvfvf ifalatilli vcscyvtply rmhhkmgtwn wssaldcafi gafsiefivk 1261 tvadgfiysp naylrnpwnf idfcvlismw inliaylknn gnlsrifkgl talralrclt 1321 isntarqtfn lvmfdglnki feaglislsl lfpftvwgls ifkgrlgtcn dgslgradcy 1381 neysnsvfqw dimsprvyqq pylhldsfas afsslyqiis legwvdllen mmnssgigtp 1441 atvmgsagna lflvlfnfls mvfilnlfvs fivnnqartt gsayftieek awlesqklls 1501 qakpkaipnl ielsrvrqff yqlavekknf yyasflqvvl ylhiimllsr synpgnligy 1561 qgvyfmfsts vfliqealhm cgegprlyfr qkwnsirlsi iiiafimnav afhvpashyw 1621 fhnikgffll viflfiipqn dtltelleta maslppilsl tytwgvlflv yaialnqifg 1681 ltrlgsnttd ninfrtviks mivlfrcsfg egwnyimadl tvsepycssd dnstytdcgs 1741 etyaylllms wniismyifv nmfvsliign fsyvyrsggs rsginrseik kyieawskfd 1801 tdgtgelels ylprimhsfd gplsfkiweg rltikslven ymevnpddpy dvkidligln 1861 kelntidkak iiqrklqyrr fvqsihytna yngcirfsdl llqiplytay sareclgidq 1921 yvhhlyilgk vdkylenqrn fdvlemvvtr wkfhcrmkrt iepewdvkdp tvsshisnin 1981 vnlepapgil erepiatprm dygvnnfmws prmnqdstme ppeepidnnd dsandlidr // LOCUS NP_011734 1084 aa linear PLN 30-JUN-2025 DEFINITION exportin CRM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011734 VERSION NP_011734.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181347.3 REFERENCE 1 (residues 1 to 1084) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1084) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1084) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1084) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1084) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1084) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1084) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1084) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08312. On Jul 30, 2012 this sequence version replaced NP_011734.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1084 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1084 /product="exportin CRM1" /calculated_mol_wt="123974" Region 1..1070 /region_name="CRM1" /note="Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]; COG5101" /db_xref="CDD:227432" CDS 1..1084 /gene="CRM1" /locus_tag="YGR218W" /gene_synonym="KAP124; XPO1" /coded_by="NM_001181347.3:1..3255" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:19139260]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9891088]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:18573877]" /experiment="EXISTENCE:direct assay:GO:0006409 tRNA export from nucleus [PMID:36099418]" /experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030619 U1 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030621 U4 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030623 U5 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:9857197]" /experiment="EXISTENCE:genetic interaction:GO:0034501 protein localization to kinetochore [PMID:19139260]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11313466]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:9323132]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:33481703|PMID:9323132]" /experiment="EXISTENCE:mutant phenotype:GO:0051168 nuclear export [PMID:31189105]" /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:9323132]" /experiment="EXISTENCE:mutant phenotype:GO:0071528 tRNA re-export from nucleus [PMID:33074312]" /note="Nuclear export factor, exportin; major karyopherin involved in export of proteins, RNAs, and ribosomal subunits from the nucleus" /db_xref="GeneID:853133" /db_xref="SGD:S000003450" ORIGIN 1 megildfsnd ldialldqvv stfyqgsgvq qkqaqeiltk fqdnpdawqk adqilqfstn 61 pqskfialsi ldklitrkwk llpndhrigi rnfvvgmiis mcqddevfkt qknlinksdl 121 tlvqilkqew pqnwpefipe ligsssssvn vcennmivlk llseevfdfs aeqmtqakal 181 hlknsmskef eqifklcfqv leqgssssli vatlesllry lhwipyryiy etnilellst 241 kfmtspdtra itlkcltevs nlkipqdndl ikrqtvlffq ntlqqiatsv mpvtadlkat 301 yanangndqs flqdlamflt tylarnrall esdeslrell lnahqyliql skieerelfk 361 ttldywhnlv adlfyevqrl patemspliq lsvgsqaist gsgalnpeym krfplkkhiy 421 eeicsqlrlv iienmvrpee vlvvendege ivrefvkesd tiqlyksere vlvylthlnv 481 idteeimisk larqidgsew swhnintlsw aigsisgtms edtekrfvvt vikdlldltv 541 kkrgkdnkav vasdimyvvg qyprflkahw nflrtvilkl fefmhetheg vqdmacdtfi 601 kivqkckyhf viqqpresep fiqtiirdiq kttadlqpqq vhtfykacgi iiseersvae 661 rnrllsdlmq lpnmawdtiv eqstanptll ldsetvkiia niiktnvavc tsmgadfypq 721 lghiyynmlq lyravssmis aqvaaeglia tktpkvrglr tikkeilklv etyiskarnl 781 ddvvkvlvep llnavledym nnvpdardae vlncmttvve kvghmipqgv ililqsvfec 841 tldminkdft eypehrvefy kllkvineks faaflelppa afklfvdaic wafkhnnrdv 901 evnglqiald lvkniermgn vpfanefhkn yffifvsetf fvltdsdhks gfskqalllm 961 klislvydnk isvplyqeae vpqgtsnqvy lsqylanmls nafphltseq iasflsaltk 1021 qykdlvvfkg tlrdflvqik evggdptdyl faedkenalm eqnrlereka akiggllkps 1081 eldd // LOCUS NP_011736 269 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL3m MRPL9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011736 VERSION NP_011736.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181349.1 REFERENCE 1 (residues 1 to 269) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 269) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 269) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 269) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08313. Method: conceptual translation. FEATURES Location/Qualifiers source 1..269 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..269 /product="mitochondrial 54S ribosomal protein uL3m MRPL9" /calculated_mol_wt="29659" Region 60..268 /region_name="RplC" /note="Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]; COG0087" /db_xref="CDD:439857" CDS 1..269 /gene="MRPL9" /locus_tag="YGR220C" /gene_synonym="uL3m" /coded_by="NM_001181349.1:1..810" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:1597181]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:2060626]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:853135" /db_xref="SGD:S000003452" ORIGIN 1 mskflqgsif sisklhvrys strpflvaps iansitteap ainhspelan arkwlpkrcg 61 litrkkgmmp yfdkstgers aatilevnnv evimhrtsev ngyfacqvgy gsrhlskvsr 121 qmlghfaskv vnpkehvaef rvkdekglip pgtllkpsff kegqyvdvrs vskgkgftgv 181 mkrygfkglr ashgtsimhr hggsygqnqd pgrvlpgrkm pghmgnehvt iqnvkvlkvd 241 dennviwvkg svagpknsfv kiqdaikkt // LOCUS NP_011737 622 aa linear PLN 30-JUN-2025 DEFINITION Tos2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011737 VERSION NP_011737.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181350.2 REFERENCE 1 (residues 1 to 622) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 622) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 622) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 622) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08314. On Apr 26, 2011 this sequence version replaced NP_011737.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..622 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..622 /product="Tos2p" /calculated_mol_wt="69340" Region 63..612 /region_name="SKG6" /note="SKG6 family; pfam08693" /db_xref="CDD:462564" CDS 1..622 /gene="TOS2" /locus_tag="YGR221C" /coded_by="NM_001181350.2:1..1869" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11489916]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11489916|PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15282802|PMID:11489916]" /experiment="EXISTENCE:genetic interaction:GO:0030427 site of polarized growth [PMID:14872283]" /experiment="EXISTENCE:genetic interaction:GO:0032507 maintenance of protein location in cell [PMID:14872283]" /experiment="EXISTENCE:mutant phenotype:GO:1902413 negative regulation of mitotic cytokinesis [PMID:16816427]" /note="Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p; TOS2 has a paralog, SKG6, that arose from the whole genome duplication" /db_xref="GeneID:853136" /db_xref="SGD:S000003453" ORIGIN 1 mfshyryken scqkreaipd ksrvsltflq krtdssnvtv avavavpiga iiivlsvvli 61 vvyrrckkep smqdfdpnfe gdlyylpkmd ssmnsansds natekrfiyg gyddflqpsi 121 ensqsfkdyv rrinehapsa yniaslasqn nsklsvpskh idlsnkisfe slenselivs 181 pqhsntgqdc dqrcdstsnp dvneksshnn dnrlksnyts rsglepqcsr eeeenidrir 241 siyniyfeks nstirssvts sirrdsklni atrksvnmss qdnpndttli eqshfgsttv 301 qeidssssan eeyedatdyl qvpapqenkn iassvyseva trekvipess lsltfpppng 361 lstritssiy sdtvakdhih sakapvrals egsgqsnlts aqqystyfid hcnqsnddny 421 yynyplpleh pqnyenigdl ptptqfiyst sshsltsfkg rpkppktlkh vptarlngta 481 lnpmdhpemf yssptkipst sltkqfctpl pyqlrqsvvm tnpselsmkp rykpagslrn 541 likaqylpgn sstttsssls qppstlsnai nfrvsglldd tdilqppsvg eilpfkaste 601 dlrkqlgtsh nyeitpyenv hv // LOCUS NP_011738 293 aa linear PLN 30-JUN-2025 DEFINITION Pet54p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011738 VERSION NP_011738.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181351.3 REFERENCE 1 (residues 1 to 293) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 293) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 293) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 293) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08315. On Jul 30, 2012 this sequence version replaced NP_011738.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..293 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..293 /product="Pet54p" /calculated_mol_wt="34506" Region 211..270 /region_name="RRM_1" /note="RNA recognition motif; smart00361" /db_xref="CDD:214637" CDS 1..293 /gene="PET54" /locus_tag="YGR222W" /coded_by="NM_001181351.3:1..882" /experiment="EXISTENCE:direct assay:GO:0000372 Group I intron splicing [PMID:18388132]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8389363]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8389363]" /experiment="EXISTENCE:direct assay:GO:0048027 mRNA 5'-UTR binding [PMID:18388132]" /experiment="EXISTENCE:direct assay:GO:0097157 pre-mRNA intronic binding [PMID:18388132]" /experiment="EXISTENCE:mutant phenotype:GO:0000372 Group I intron splicing [PMID:9341683]" /experiment="EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:2548921]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:2548921]" /experiment="EXISTENCE:mutant phenotype:GO:0090615 mitochondrial mRNA processing [PMID:9341683]" /note="Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; also stimulates efficient synthesis of Cox1p" /db_xref="GeneID:853137" /db_xref="SGD:S000003454" ORIGIN 1 mkasskaikl vldhlkstgr vlgsvesgns atisektasv nkqqqlqekk psvlqyrsyn 61 pylvkedfls ilpenlykkr gqftneldfq lmkvrdpkyf qfkdqyylff ndynslteyi 121 kltkhsrink irvkmtplaq plptlltklq rysknlynaf rsseqyfegl nekvdvsgef 181 ttnqlrsild sveeienksv lvwniptklr shdilnyfwf ynirssfkiy wddemkrnlr 241 fisfenshda yrfkrnyhgl lakelltlse kgdaadysle mddskilieh lse // LOCUS NP_011739 448 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol-3,5-bisphosphate binding protein HSV2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011739 VERSION NP_011739.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181352.1 REFERENCE 1 (residues 1 to 448) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 448) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 448) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 448) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08316. Method: conceptual translation. FEATURES Location/Qualifiers source 1..448 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..448 /product="phosphatidylinositol-3,5-bisphosphate binding protein HSV2" /calculated_mol_wt="51104" Region <220..>296 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 228..267 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 272..298 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..448 /gene="HSV2" /locus_tag="YGR223C" /coded_by="NM_001181352.1:1..1347" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:15155809]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15103325]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:18769150]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:22704557]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:15155809|PMID:22704557|PMID:22753491]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:15155809]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:22753491|PMID:22704557|PMID:15103325]" /experiment="EXISTENCE:mutant phenotype:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:22704557|PMID:22753491]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18769150]" /experiment="EXISTENCE:mutant phenotype:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:22704557|PMID:22753491]" /note="Phosphoinositide (PI) binding protein; involved in micronucleophagy; belongs to the PROPPIN family of proteins defined by a seven-bladed beta-propeller fold and FRRG motif required for PI binding; displays punctate cytoplasmic localization" /db_xref="GeneID:853138" /db_xref="SGD:S000003455" ORIGIN 1 mdvrrpirea vnnrrkpkfl svsfnqddsc fsvalengfr ifntdpltsk lsktfkesat 61 nqsrgtgigy trmlyrtnyi alvgggkrpr halnkliiwd dllqketitl kfmssikdvf 121 lsrihivvvl entieifqfq tnpqricpil dippngsvdy vvcsskhlqs qasqsqskil 181 eiiafpsnkc vgqiqvadls qikynsqnpk esallptsii kahknpiklv rlnrqgtmva 241 tcsvqgtlir ifsthngtli kefrrgvdka diyemsfspn gsklavlsnk qtlhifqife 301 ttntetntpd hsrangsshp lknyipkglw rpkyldsvws icnahlknpi fdahrndnsg 361 dvthdnefyk drcrigwcqd snnreqddsl vlvwqnsgiw ekfvilekeq qdsskthysl 421 neslrnedtk sageptrwel vreswrel // LOCUS NP_011740 613 aa linear PLN 30-JUN-2025 DEFINITION azole transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_011740 VERSION NP_011740.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181353.3 REFERENCE 1 (residues 1 to 613) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 613) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 613) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 613) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08317. On Jul 30, 2012 this sequence version replaced NP_011740.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..613 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..613 /product="azole transporter" /calculated_mol_wt="67038" Region 83..540 /region_name="MFS_Azr1_MDR_like" /note="Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17502" /db_xref="CDD:341045" Site order(84..85,88,119,169..170,172..174,177,197,200..201,204, 385,388..389,392..394,397,425,429,482..483,487,491,513, 516..517,520..521,524) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:341045" CDS 1..613 /gene="AZR1" /locus_tag="YGR224W" /coded_by="NM_001181353.3:1..1842" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11113970]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0045117 azole transmembrane transport [PMID:11113970]" /experiment="EXISTENCE:mutant phenotype:GO:1901474 azole transmembrane transporter activity [PMID:11113970]" /note="Plasma membrane transporter of the major facilitator superfamily; involved in resistance to azole drugs such as ketoconazole and fluconazole" /db_xref="GeneID:853139" /db_xref="SGD:S000003456" ORIGIN 1 mkgepktysm sdlsyygeka qqqnekqqkq yvvrrnstqs tskqnvsvvl ednasesnel 61 pkgfilyasl ialalslfla aldimivsti ieevakqfgs yseigwlftg yslpnallal 121 iwgriatpig fketmlfaiv ifeigslisa lansmsmlig grviagvggc giqslsfvig 181 stlveesqrg iliavlscsf aiasvvgpfl ggvftssvtw rwcfyvnlpi gglafflflf 241 fynpglstfq etmdnirkfp sqfieivrnv ayhllkikgf sklngwrkpf melifmydii 301 efvfcsagft cillaftfgg nryawnsasi iilfiigivl vvlagiydfl vfpkfnivka 361 tphyqplmsw tnikkpgift vnialfltca gyisqftyiv qyfqliynds awraavhlva 421 ciistvvtai lcgaitdktr qikpiiviss ifgvvgagil tllnnnanns ahigllilpg 481 vafgglaqss mlasqiqldk ksptfrsdfv sittfntfck nlgqalggvi sntvfsaaai 541 kkltkaniql pdgttvdnlv iyrqtnfdgs hsklgniise sltdvfymal gfyalslifa 601 vfasnkkvta slr // LOCUS NP_011741 593 aa linear PLN 30-JUN-2025 DEFINITION Ama1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011741 VERSION NP_011741.5 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181354.3 REFERENCE 1 (residues 1 to 593) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 593) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 593) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 593) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08318. On Jul 30, 2012 this sequence version replaced NP_011741.4. Method: conceptual translation. FEATURES Location/Qualifiers source 1..593 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..593 /product="Ama1p" /calculated_mol_wt="66896" Region 234..271 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 266..561 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(272,290,294,300..301,312..313,344,348,354,376, 388..389,406,411,417..418,433,451,458,464..465,477,495,501, 511..512,525..526,543,548,554..555) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 276..321 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 328..374 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 394..432 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 437..474 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 482..523 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..593 /gene="AMA1" /locus_tag="YGR225W" /gene_synonym="SPO70" /coded_by="NM_001181354.3:1..1782" /experiment="EXISTENCE:direct assay:GO:1990757 ubiquitin ligase activator activity [PMID:15797379]" /experiment="EXISTENCE:genetic interaction:GO:1903024 positive regulation of ascospore-type prospore membrane formation [PMID:32788308]" /experiment="EXISTENCE:mutant phenotype:GO:0007127 meiosis I [PMID:11114178]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:23101628]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11114178]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]" /experiment="EXISTENCE:mutant phenotype:GO:0044778 meiotic DNA integrity checkpoint signaling [PMID:23101628]" /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:23101628]" /experiment="EXISTENCE:mutant phenotype:GO:0045732 positive regulation of protein catabolic process [PMID:21118994]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:11114178]" /experiment="EXISTENCE:mutant phenotype:GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process [PMID:11114178]" /experiment="EXISTENCE:physical interaction:GO:0005680 anaphase-promoting complex [PMID:11114178]" /note="Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis; prevents premature assembly of the meiosis I spindle, required for DSB induced prophase I arrest" /db_xref="GeneID:853140" /db_xref="SGD:S000003457" ORIGIN 1 matphlyhry nskssnknin ssgnstevdr fipksvsrna yksipmlngf disyselcek 61 spsperlssp effnelrntg hyesisttne fsmssissss esqvtrsgsa rasrndyskl 121 tkeqkdhrkn iahslgfqlp drvftfetts aeileknkai kncfgpgsca eirstfdfst 181 lspdvaryyi ansnarsasp qrqiqrpakr vkshipyrvl dapclrndfy snliswsrtt 241 nnvlvglgcs vyiwsekega vsildhqyls ekrdlvtcvs fcpyntyfiv gtkfgrilly 301 dqkeffhssn tnekepvfvf qtesfkgicc lewfkpgeic kfyvgeengn vslfeikslh 361 fpiknwskrq kledenligl klhstyqaqa qqvcgislne hanllavggn dnscslwdis 421 dldkpikkfv lphkaavkai afcpwsksll atgggskdrc ikfwhtstgt lldeictsgq 481 vtsliwslrh kqivatfgfg dtknpvlitl ysypklskll evrspnplrv lsavispssm 541 aicvatndet irfyelwndk eeiineiqes giygsniiey megietthnk rir // LOCUS NP_011743 525 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011743 VERSION NP_011743.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181356.2 REFERENCE 1 (residues 1 to 525) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 525) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 525) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 525) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08319. On Apr 26, 2011 this sequence version replaced NP_011743.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..525 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..525 /product="dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase" /EC_number="2.4.1.256" /calculated_mol_wt="61662" Region 66..458 /region_name="DIE2_ALG10" /note="DIE2/ALG10 family; pfam04922" /db_xref="CDD:461481" CDS 1..525 /gene="DIE2" /locus_tag="YGR227W" /gene_synonym="ALG10" /coded_by="NM_001181356.2:1..1578" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0106073 dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity [PMID:9597543]" /experiment="EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:9597543]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9597543]" /note="Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase; located in the ER; functions in pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation; has a role in regulation of ITR1 and INO1; human homolog ALG10B can complement yeast die2 null mutant" /db_xref="GeneID:853142" /db_xref="SGD:S000003459" ORIGIN 1 mdakkntgea nndvleeeaa iqliapgiar nltqevitgi fcnvviypll liyfvltfry 61 mttnivpyef idekfhvgqt ltylkgkwtq wdpkittppg iyilglinyy cikpifksws 121 tltilrlvnl lggiivfpil vlrpiflfna lgfwpvslms fplmttyyyl fytdvwstil 181 ilqslscvlt lpfgpvksiw lsaffagvsc lfrqtniiwt gfimilaver pailqkqfnt 241 htfnnylklf ihaiddfsnl vlpyminfvl ffiyliwnrs itlgdksshs aglhivqify 301 cftfitvfsl piwisrnfmk lyklrikrkp vqtffefigi mliiryftkv hpflladnrh 361 ytfylfrrli gnksrlikyf fmtpiyhfst faylevmrpn qltfhpitpl pikepvhlpi 421 qlthvswtal itctmvtivp splfepryyi lpyffwrifi tcsceplikd lkpakegenp 481 itisstkrlf meflwfmlfn vvtlvifskv sfpwttepyl qriiw // LOCUS NP_001382660 57 aa linear PLN 30-JUN-2025 DEFINITION Oto1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001382660 VERSION NP_001382660.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395731.1 REFERENCE 1 (residues 1 to 57) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 57) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 57) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 57) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAF84567. Method: conceptual translation. FEATURES Location/Qualifiers source 1..57 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..57 /product="Oto1p" /calculated_mol_wt="6529" CDS 1..57 /gene="OTO1" /locus_tag="YGR227C-A" /coded_by="NM_001395731.1:1..174" /note="Small toxic protein; overexpression inhibits ergosterol biosynthesis; not required for normal growth, not conserved in related yeast species including S. paradoxus" /db_xref="GeneID:65924736" /db_xref="SGD:S000303806" ORIGIN 1 mnvrgnqcim sirvflkage sslsfaikwl krfeattkkn qyiqngwplk dgnkkrk // LOCUS NP_011745 505 aa linear PLN 30-JUN-2025 DEFINITION Smi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011745 VERSION NP_011745.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181358.1 REFERENCE 1 (residues 1 to 505) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 505) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 505) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 505) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08320. Method: conceptual translation. FEATURES Location/Qualifiers source 1..505 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..505 /product="Smi1p" /calculated_mol_wt="56948" Region 93..313 /region_name="SMI1" /note="Cell wall assembly regulator SMI1 (Killer toxin-resistance protein 4) [Cell wall/membrane/envelope biogenesis]; COG4282" /db_xref="CDD:443423" Region <329..>501 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" CDS 1..505 /gene="SMI1" /locus_tag="YGR229C" /gene_synonym="KNR4" /coded_by="NM_001181358.1:1..1518" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10206705]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10206705]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0007346 regulation of mitotic cell cycle [PMID:11410349]" /experiment="EXISTENCE:genetic interaction:GO:0032995 regulation of fungal-type cell wall biogenesis [PMID:10206705]" /experiment="EXISTENCE:mutant phenotype:GO:0007346 regulation of mitotic cell cycle [PMID:12823808]" /experiment="EXISTENCE:mutant phenotype:GO:0032995 regulation of fungal-type cell wall biogenesis [PMID:10206705]" /note="Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity" /db_xref="GeneID:853144" /db_xref="SGD:S000003461" ORIGIN 1 mdlfkrkvke wvyslstddh yaeynpdetp tfnmgkrlns nngqvnpsqm hlnsvdeems 61 mgfqngvpsn edinidefts tesndgvset llawrhidfw tsehnpdlna tlsdpctqnd 121 ithaeedlev sfpnpvkasf kihdgqedle smtgtsglfy gfqlmtldqv vamtqawrnv 181 aknlnkrsqq glshvtstgs sssmerlngn kfklpnipdq ksippnavqp vyahpawipl 241 itdnagnhig vdlapgpngk yaqiitfgrd fdtkfviaen wgefllsfan dleagnwylv 301 ddnddyfsgd gelvfrdkks ngpiqdyfev lkrrtwikyq enlrsqqqks qpdtslqeqk 361 yvpasqkkva aeqpstlnae sikgedsgsa dvqsvqdhes vkivktepse aetttvntes 421 lgqaeheika dnvdikqese rkedekqpkv eekehveneh vtesakkddd vnkqteemnk 481 keeneirsdd akveeareef enial // LOCUS NP_011746 137 aa linear PLN 30-JUN-2025 DEFINITION Bns1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011746 VERSION NP_011746.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181359.3 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08321. On Jul 30, 2012 this sequence version replaced NP_011746.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..137 /product="Bns1p" /calculated_mol_wt="15709" Region 89..121 /region_name="Spo12" /note="Spo12 family; pfam05032" /db_xref="CDD:398624" CDS 1..137 /gene="BNS1" /locus_tag="YGR230W" /coded_by="NM_001181359.3:1..414" /experiment="EXISTENCE:genetic interaction:GO:0051321 meiotic cell cycle [PMID:10564265]" /experiment="EXISTENCE:genetic interaction:GO:1904750 negative regulation of protein localization to nucleolus [PMID:14551257]" /note="hypothetical protein; FEAR network component that partially overlaps the function of SPO12 in promoting Cdc14p release from the nucleolus during early mitotic anaphase and mitotic exit; overexpression partially suppresses the meiotic defect of spo12; BNS1 has a paralog, SPO12, that arose from the whole genome duplication" /db_xref="GeneID:853145" /db_xref="SGD:S000003462" ORIGIN 1 msyggsasqd ivtklirkiq ntsvsctrrd enldsfnqhl kmslkvahnt ktfakhclhr 61 qvfkntyrkr kavedqrknl ntqlrqkfas psdnllspcs rklndhkskl fsaksqpktl 121 efvrgkqnip rkpnvdi // LOCUS NP_011747 310 aa linear PLN 30-JUN-2025 DEFINITION prohibitin subunit PHB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011747 VERSION NP_011747.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181360.1 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08322. On Jul 26, 2004 this sequence version replaced NP_011747.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..310 /product="prohibitin subunit PHB2" /calculated_mol_wt="34275" Region 58..252 /region_name="SPFH_prohibitin" /note="Prohibitin family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; cd03401" /db_xref="CDD:259799" CDS 1..310 /gene="PHB2" /locus_tag="YGR231C" /coded_by="NM_001181360.1:1..933" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:9259555|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9632789|PMID:10835343]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:10835343]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:12882345]" /experiment="EXISTENCE:mutant phenotype:GO:0045861 negative regulation of proteolysis [PMID:10207067]" /note="Subunit of the prohibitin complex (Phb1p-Phb2p); prohibitin is a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation; prohibitin deficiency induces a mitochondrial unfolded protein response (mtUPR)" /db_xref="GeneID:853146" /db_xref="SGD:S000003463" ORIGIN 1 mnrspgefqr yakafqkqls kvqqtggrgq vpsprgafag lggllllggg alfinnalfn 61 vdgghraivy srihgvssri fnegthfifp wldtpiiydv rakprnvasl tgtkdlqmvn 121 itcrvlsrpd vvqlptiyrt lgqdydervl psivnevlka vvaqfnasql itqrekvsrl 181 irenlvrras kfnillddvs itymtfspef tnaveakqia qqdaqraafv vdkarqekqg 241 mvvraqgeak saeligeaik ksrdyvelkr ldtardiaki lasspnrvil dnealllntv 301 vdaridgrgk // LOCUS NP_011748 228 aa linear PLN 30-JUN-2025 DEFINITION Nas6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011748 VERSION NP_011748.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181361.3 REFERENCE 1 (residues 1 to 228) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 228) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 228) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 228) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08323. On Jul 30, 2012 this sequence version replaced NP_011748.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..228 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..228 /product="Nas6p" /calculated_mol_wt="25485" Region 1..33 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 3..226 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 35..69 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 71..104 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 107..137 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(108,112..113,116..118,120..121,125,128,137,139,141, 145..146,149..151,153..154,158,161,171,173,175,179..180, 183..185,187..188,192,195,205) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 139..171 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 173..205 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..228 /gene="NAS6" /locus_tag="YGR232W" /coded_by="NM_001181361.3:1..687" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19446323]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:19446323]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:19412159]" /experiment="EXISTENCE:direct assay:GO:1904855 proteasome regulatory particle binding [PMID:11029046]" /experiment="EXISTENCE:genetic interaction:GO:0070682 proteasome regulatory particle assembly [PMID:19446322|PMID:19412159|PMID:19446323]" /experiment="EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19446322|PMID:19446323]" /note="Evolutionarily conserved 19S regulatory particle assembly-chaperone; proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, also known as p28, which interacts with the Rb tumor suppressor and CDK4/6" /db_xref="GeneID:853147" /db_xref="SGD:S000003464" ORIGIN 1 msnyplhqac meneffkvqe llhskpslll qkdqdgripl hwsvsfqahe itsfllskme 61 nvnlddypdd sgwtpfhiac svgnlevvks lydrplkpdl nkitnqgvtc lhlavgkkwf 121 evsqflieng asvrikdkfn qiplhraasv gslkliellc glgksavnwq dkqgwtplfh 181 alaeghgdaa vllvekygae ydlvdnkgak aedvalneqv kkfflnnv // LOCUS NP_011749 1178 aa linear PLN 30-JUN-2025 DEFINITION Pho81p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011749 VERSION NP_011749.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181362.3 REFERENCE 1 (residues 1 to 1178) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1178) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1178) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1178) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08324. On Jul 30, 2012 this sequence version replaced NP_011749.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1178 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1178 /product="Pho81p" /calculated_mol_wt="133899" Region 2..159 /region_name="SPX_PHO81_NUC-2_like" /note="SPX domain of Pho81, NUC-2, and similar proteins; cd14483" /db_xref="CDD:269904" Region 395..690 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 423..456 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 458..495 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 508..540 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 561..588 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(562..563,567..569,571..572,576,579,588,590,593, 597..598,601..603,605..606,610,613,622,624,626,630..631, 634..636,638..639,643,646) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 590..622 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 875..1172 /region_name="GDPD_NUC-2_fungi" /note="Putative glycerophosphodiester phosphodiesterase domain of ankyrin repeat protein NUC-2 and similar proteins; cd08578" /db_xref="CDD:176520" CDS 1..1178 /gene="PHO81" /locus_tag="YGR233C" /gene_synonym="VAC6" /coded_by="NM_001181362.3:1..3537" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16611745|PMID:14562095|PMID:22842922|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:38316984]" /experiment="EXISTENCE:mutant phenotype:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:7939631|PMID:11069666]" /experiment="EXISTENCE:mutant phenotype:GO:0006796 phosphate-containing compound metabolic process [PMID:4570606]" /experiment="EXISTENCE:mutant phenotype:GO:0016036 cellular response to phosphate starvation [PMID:38316984|PMID:7939631]" /note="Cyclin-dependent kinase (CDK) inhibitor; regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p; senses phosphate metabolites via the SPX domain to regulate pexophagy in response to phosphate starvation; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:853148" /db_xref="SGD:S000003465" ORIGIN 1 mkfgkylear qlelaeynsh fidykalkkl ikqlaiptlk assdldlhlt lddidekiih 61 qrlqenkaaf ffklerelek vngyylares dlrikfnilh skykdyking klnsnqatsf 121 knlyaafkkf qkdlrnleqy velnktgfsk alkkwdkrsq shdkdfylat vvsiqpiftr 181 dgplklndet lhillelndi dnnnrradiq sstftndddd dnntsnnnkh nnnnnnnnnn 241 nnnnnnnnil hnnyelttsk isenqlehlf qassssldme meienwykei lniatvkdvq 301 rkhallrnfr etkiftyllq nssesfhknv fsllkecltt lflllvaspl ddnslhifyk 361 snqdhidlsy cdeddqvfsr knvfheaasc peksrlfild ealttsklsk etvqkllnaq 421 dihsrvplhy aaelgklefv hsllitnlle dvdpidsdsk tplvlaitnn hidvvrdllt 481 igganaspie kpildysknv isstkvqfdp lnvackfnnh daakllleir skqnadnakn 541 kssqhlcqpl fkknstglct lhivakiggd pqliqlliry gadpneidgf nkwtpifyav 601 rsghsevite llkhnarldi eddnghsplf yalweshvdv lnallqrpln lpsaplnein 661 sqsstqrlnt idltpnddkf dldiqdsipd falpppiipl rkyghnflek kifiklklrp 721 glesikltqd ngiimssspg ritlssnlpe iiprnvilpv rsgeinnfck disetndeed 781 ddeisedhdd geiifqvdsi ddfsmdfeif psfgtriiak ttampflfkk vainsiatmn 841 lplfdtrlnn igsltldyqi ifpypgnplk iinyepywks tgsdlmtssk dgnfvtsssl 901 ngsfisvlvc alndetivaa pkpyvefkgt killndltke qlekvvdydf gkidgsfdev 961 tlkqylssrv vplrsllevi pgsaqlvirv yfptdkeidt ipikispfin inqfidklll 1021 iifeherflr hsgsgsmrqi vfsscnweac silnwkqpnf pvllqmknll rdsttgkfvg 1081 dtpnclkela vnpqkmsyln telinihtmv qfamnnnllg vtlpyevlki cpslariikq 1141 ngllliasvg endqipadgg ysgiyyacel lfennidm // LOCUS NP_011750 399 aa linear PLN 30-JUN-2025 DEFINITION flavohemoglobin [Saccharomyces cerevisiae S288C]. ACCESSION NP_011750 VERSION NP_011750.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181363.1 REFERENCE 1 (residues 1 to 399) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 399) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 399) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 399) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08325. Method: conceptual translation. FEATURES Location/Qualifiers source 1..399 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..399 /product="flavohemoglobin" /EC_number="1.14.12.17" /calculated_mol_wt="44515" Region 1..392 /region_name="PRK13289" /note="NO-inducible flavohemoprotein" /db_xref="CDD:237337" CDS 1..399 /gene="YHB1" /locus_tag="YGR234W" /gene_synonym="YHB4" /coded_by="NM_001181363.1:1..1200" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:15611069]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15611069]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0034599 cellular response to oxidative stress [PMID:8810268|PMID:9545281]" /experiment="EXISTENCE:mutant phenotype:GO:0016966 nitric oxide reductase activity [PMID:10758168|PMID:15611069]" /experiment="EXISTENCE:mutant phenotype:GO:0071218 cellular response to misfolded protein [PMID:27341336]" /experiment="EXISTENCE:mutant phenotype:GO:1902170 cellular response to reactive nitrogen species [PMID:27341336]" /note="Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:853149" /db_xref="SGD:S000003466" ORIGIN 1 mlaektrsii katvpvleqq gtvitrtfyk nmltehtell nifnrtnqkv gaqpnalatt 61 vlaaaknidd lsvlmdhvkq ighkhralqi kpehypivge yllkaikevl gdaatpeiin 121 awgeayqaia difitvekkm yeealwpgwk pfditakeyv asdiveftvk pkfgsgiele 181 slpitpgqyi tvnthpirqe nqydalrhys lcsastkngl rfavkmeaar enfpaglvse 241 ylhkdakvgd eiklsapagd fainkelihq nevplvllss gvgvtpllam leeqvkcnpn 301 rpiywiqssy dektqafkkh vdellaecan vdkiivhtdt eplinaaflk ekspahadvy 361 tcgslafmqa mighlkeleh rddmihyepf gpkmstvqv // LOCUS NP_011751 233 aa linear PLN 30-JUN-2025 DEFINITION Mic26p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011751 VERSION NP_011751.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181364.1 REFERENCE 1 (residues 1 to 233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 233) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08326. Method: conceptual translation. FEATURES Location/Qualifiers source 1..233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..233 /product="Mic26p" /calculated_mol_wt="26781" Region 59..184 /region_name="ApoO" /note="Apolipoprotein O; pfam09769" /db_xref="CDD:462891" CDS 1..233 /gene="MIC26" /locus_tag="YGR235C" /gene_synonym="MCS29; MIO27; MOS2" /coded_by="NM_001181364.1:1..702" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0044284 mitochondrial crista junction [PMID:22009199]" /experiment="EXISTENCE:direct assay:GO:0061617 MICOS complex [PMID:21944719|PMID:21987634|PMID:22009199]" /experiment="EXISTENCE:mutant phenotype:GO:0032460 negative regulation of protein oligomerization [PMID:29733859]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:22009199|PMID:21987634]" /note="Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; negative regulator of Mic10p oligomerization; Mic26p is a non-essential component of the complex; orthologous to human APOO and APOOL" /db_xref="GeneID:853150" /db_xref="SGD:S000003467" ORIGIN 1 mtkdfyrqld pveekivppe naivisseak eatvnekeak qgvlsqrvmk yigenelvdg 61 isvrdpdylk rffnerrkqf sakwdkvtnk iddiagryya reesftstia slhtdpnerl 121 ipgllsilva smtgsvlarr rtwllratmp iilgsccfay ampttfrntm glihnlemnt 181 fphfterqdr vwketkrlst asvqyyydak kwlnkdvekt gnaiknwtgv nvk // LOCUS NP_011752 95 aa linear PLN 30-JUN-2025 DEFINITION Spg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011752 VERSION NP_011752.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181365.3 REFERENCE 1 (residues 1 to 95) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 95) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 95) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 95) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 95) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08327. On Jul 30, 2012 this sequence version replaced NP_011752.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..95 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..95 /product="Spg1p" /calculated_mol_wt="10414" CDS 1..95 /gene="SPG1" /locus_tag="YGR236C" /coded_by="NM_001181365.3:1..288" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:853151" /db_xref="SGD:S000003468" ORIGIN 1 mkldsgiyse aqrvvrtpkf ryimlglvga avvptaymrr gytvpahsld ningvdttka 61 svmgteqraa mtkgkslqem mdddevtylm fssim // LOCUS NP_011753 785 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR237C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011753 VERSION NP_011753.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181366.1 REFERENCE 1 (residues 1 to 785) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 785) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 785) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 785) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08328. Method: conceptual translation. FEATURES Location/Qualifiers source 1..785 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..785 /product="uncharacterized protein" /calculated_mol_wt="89110" Region 353..517 /region_name="AANH_superfamily" /note="Adenine nucleotide alpha hydrolase (AANH) superfamily; cl00292" /db_xref="CDD:469708" CDS 1..785 /locus_tag="YGR237C" /coded_by="NM_001181366.1:1..2358" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:37387118]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:853152" /db_xref="SGD:S000003469" ORIGIN 1 mssaktftkh isfddlapsl iddqatiikn dshhvglnnh flhippqfnp vykntltgsh 61 gsndlatdes ldspedeeas splqlgtpts ttsgvphfyt qvfspaahdp sksylrspsv 121 ersrsespmf rsrrrtsvrl ppppkvsvlk ksrkaadeqg piddidigdl dfelerkmtk 181 mterntqkns gsrkgytqaa fanlnevedr ietksmvdls esenmesskk rsksfagmtd 241 eelakleefy iskgrsnktk idqfdfgeqv pvylnttesk tdssnvtdpl aaiypsrpti 301 vhnaismtid hpdyenyisn tkeklnckdk dddvdlrvvs cyisgrrytw ssvdwyvenl 361 trngdhlvii ttipefeaki dtlaykekrr hrlermtsnt sesmttashs ligpdlsspl 421 stgirieaih neakqtcsdi lnyyarrlat kivrisiemv kenstrsaii satslyrpsl 481 qvistvsani qikfrngkvk lpfflmkhfa mpafvvpfef ikpellikpr vdkdeqdnsd 541 dlktevrkke rlqwlsalir rtlenpftkh kvvdsddees dsdesvtsvn eyfpispekk 601 eemeffdkmg yvrpkpsrqv llddntlmky dssgrkltpi esrnsrrssk rssriqfnnn 661 giykvksmvd diynhetast phiktalkwd nedpkmkfts hpmrktksag lsprtsstss 721 ssgqrkahhh hhhhnhvsrt kttestksgn skkdssssst ndhqfkrsek kkkskfgsif 781 kkvfg // LOCUS NP_011754 882 aa linear PLN 30-JUN-2025 DEFINITION Kel2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011754 VERSION NP_011754.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181367.3 REFERENCE 1 (residues 1 to 882) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 882) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 882) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 882) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 882) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 882) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 882) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 882) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08329. On Jul 30, 2012 this sequence version replaced NP_011754.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..882 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..882 /product="Kel2p" /calculated_mol_wt="99844" Region 77..391 /region_name="NanM" /note="N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; COG3055" /db_xref="CDD:442289" Region 142..190 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 257..308 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 310..353 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region <603..872 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" CDS 1..882 /gene="KEL2" /locus_tag="YGR238C" /coded_by="NM_001181367.3:1..2649" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:9786949]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9786949]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9786949|PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:1990615 Kelch-containing formin regulatory complex [PMID:24828508]" /experiment="EXISTENCE:genetic interaction:GO:0032465 regulation of cytokinesis [PMID:24828508]" /experiment="EXISTENCE:genetic interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:24828508]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:9786949]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:12234925]" /experiment="EXISTENCE:mutant phenotype:GO:0060627 regulation of vesicle-mediated transport [PMID:24828508]" /note="Protein that negatively regulates mitotic exit; forms a complex with Kel1p and Bud14p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate" /db_xref="GeneID:853153" /db_xref="SGD:S000003470" ORIGIN 1 mvpfkltnkv ptdtgpslis aqsvprpivf mdnrnntriv tptlppnqhr gisgastalp 61 wspeskntgk yiwnrvklkn spfpryrhss sfivtndnri fvtgglhdqs vygdvwqiaa 121 nadgtsftsk rididqntpp prvghastic gnayvvfggd thklnkngll dddlylfnin 181 sykwtipqpi grrplgrygh kisiiasnpm qtklylfggq vdetyfndlv vfdlssfrrp 241 nshweflepv gdlpppltnh tmvaydnklw vfggetpkti sndtyrydpa qsewskvktt 301 gekpppiqeh asvvykhlmc vlggkdthna ysndvyflnl lslkwyklpr mkegipqers 361 ghsltlmkne kllimggdkt dyaspnihdl qtsetdqgeg tllytldlss lnelcpgimc 421 eslhagesfs nslsggftps kstesenqei iniltprlpd skvlsyndid egagsyssal 481 ddkaferksd reekkpqssk vdssinkesp gtgikvskkn fpvlrgltvd seeygsssyk 541 dtscqkgipk nlfddlnlnl qtlrleaqqk eletarhisq lekevqrlmv ikeaskdsnf 601 qtarlknlei qktflesrin dlknllmvkl sqasklcdqi tiqnnglktc sehvtikrdi 661 idlenkcdvl krqneilvnn mqkitpelht ylnesscylg kllksyptsa rppssekdnq 721 iyekdslnki ekvinemhet vrakeklhle tqklnderds lranlldnnn kldalrklsd 781 gssksmdltk kaihlsqsel ekyrknnddl qkeidrikte qaeqddkqeq rgaithgnfd 841 afhrmkinnl kaelymsken rdslkdella lkkklytleq kk // LOCUS NP_011755 288 aa linear PLN 30-JUN-2025 DEFINITION Pex21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011755 VERSION NP_011755.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181368.3 REFERENCE 1 (residues 1 to 288) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 288) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 288) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 288) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08330. On Jul 30, 2012 this sequence version replaced NP_011755.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..288 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..288 /product="Pex21p" /calculated_mol_wt="32919" CDS 1..288 /gene="PEX21" /locus_tag="YGR239C" /coded_by="NM_001181368.3:1..867" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:9864360]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9864360]" /experiment="EXISTENCE:direct assay:GO:0051099 positive regulation of binding [PMID:17451428]" /experiment="EXISTENCE:genetic interaction:GO:0016558 protein import into peroxisome matrix [PMID:9864360]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:26276932]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9864360]" /note="Peroxin required for peroxisomal matrix protein targeting; acts on proteins containing the PTS2 targeting sequence; interacts with Pex7p; constitutively expressed; partially redundant with Pex18p; required for import of the Gpd1p-Pnc1p heterodimer in which only Gpd1p has a peroxisomal targeting signal; relative distribution to cytoplasmic foci increases upon DNA replication stress" /db_xref="GeneID:853154" /db_xref="SGD:S000003471" ORIGIN 1 mpsvchtspi ekiiqqghri qndslipskr tklahtelta hyatedshve khflhngsnf 61 dgidnvryqn qpspltfitp nntvdssdwv pqfssmkidd slefsseykr lysnyesqqr 121 lnssrqhlpf kncmirktsc typpqktlrq qrqgnrdnpt dafqfdaefq vlereiqker 181 yepitrrdek wfdqdqselq riatdivkcc tpppssasss stlsssvesk lseskfiqlm 241 rnissgdvtl kknadgnsas elfssnngel vgnrhifvkd eihkdild // LOCUS NP_011756 987 aa linear PLN 30-JUN-2025 DEFINITION 6-phosphofructokinase subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_011756 VERSION NP_011756.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181369.1 REFERENCE 1 (residues 1 to 987) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 987) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 987) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 987) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 987) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 987) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 987) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 987) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08331. Method: conceptual translation. FEATURES Location/Qualifiers source 1..987 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..987 /product="6-phosphofructokinase subunit alpha" /EC_number="2.7.1.11" /calculated_mol_wt="107840" Region 8..101 /region_name="Pfk_N" /note="Phosphofructokinase N-terminal domain yeast; pfam18468" /db_xref="CDD:408261" Region 206..972 /region_name="6PF1K_euk" /note="6-phosphofructokinase, eukaryotic type; TIGR02478" /db_xref="CDD:274152" CDS 1..987 /gene="PFK1" /locus_tag="YGR240C" /coded_by="NM_001181369.1:1..2964" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:0005945 6-phosphofructokinase complex [PMID:21241708|PMID:6231961|PMID:4271029]" /experiment="EXISTENCE:direct assay:GO:0006096 glycolytic process [PMID:3000145]" /experiment="EXISTENCE:genetic interaction:GO:0003872 6-phosphofructokinase activity [PMID:3007939]" /experiment="EXISTENCE:genetic interaction:GO:0006096 glycolytic process [PMID:2965996]" /experiment="EXISTENCE:mutant phenotype:GO:0003872 6-phosphofructokinase activity [PMID:3007939]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:2965996]" /experiment="EXISTENCE:mutant phenotype:GO:0051453 regulation of intracellular pH [PMID:24860096]" /note="Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes" /db_xref="GeneID:853155" /db_xref="SGD:S000003472" ORIGIN 1 mqsqdscygv afrsiitnde alfkktihfy htlgfatvkd fnkfkhgens llssgtsqds 61 lrevwlesfk lsevdasgfr ipqqeatnka qsqgallkir lvmsapidet fdtnetatit 121 yfstdlnkiv ekfpkqaekl sdtlvflkdp mgnnitfsgl anatdsapts kdafleatse 181 deiisrassd asdllrqtlg ssqkkkkiav mtsggdspgm naavravvrt gihfgcdvfa 241 vyegyegllr ggkylkkmaw edvrgwlseg gtligtarsm efrkregrrq aagnlisqgi 301 dalvvcggdg sltgadlfrh ewpslvdelv aegrftkeev apyknlsivg lvgsidndms 361 gtdstigays alericemvd yidatakshs rafvvevmgr hcgwlalmag iatgadyifi 421 peravphgkw qdelkevcqr hrskgrrnnt iivaegaldd qlnpvtandv kdalielgld 481 tkvtilghvq rggtavahdr wlatlqgvda vkavleftpe tpspligile nkiirmplve 541 svkltksvat aienkdfdka islrdtefie lyenflsttv kddgsellpv sdrlnigivh 601 vgapsaalna atraatlycl shghkpyaim ngfsgliqtg evkelswidv enwhnlggse 661 igtnrsvase dlgtiayyfq knkldgliil ggfegfrslk qlrdgrtqhp ifnipmclip 721 atvsnnvpgt eyslgvdtcl nalvnytddi kqsasatrrr vfvcevqggh sgyiasftgl 781 itgavsvytp ekkidlasir editllkenf rhdkgenrng kllvrneqas svystqllad 841 iiseaskgkf gvrtaipghv qqggvpsskd rvtasrfavk cikfieqwnk kneaspntda 901 kvlrfkfdth gekvptvehe ddsaavicvn gshvsfkpia nlwenetnve lrkgfevhwa 961 eynkigdils grlklraeva alaaenk // LOCUS NP_878083 66 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR240C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878083 VERSION NP_878083.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184552.1 REFERENCE 1 (residues 1 to 66) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 66) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 66) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 66) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08332. Method: conceptual translation. FEATURES Location/Qualifiers source 1..66 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..66 /product="uncharacterized protein" /calculated_mol_wt="7696" CDS 1..66 /locus_tag="YGR240C-A" /coded_by="NM_001184552.1:1..201" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466463" /db_xref="SGD:S000028551" ORIGIN 1 milskhvnft yhtynliynf ypdltnfgmp gsiyglqssl ktmekhveip qsihhyspfy 61 qlplif // LOCUS NP_011757 568 aa linear PLN 30-JUN-2025 DEFINITION Yap1802p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011757 VERSION NP_011757.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181370.3 REFERENCE 1 (residues 1 to 568) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 568) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 568) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 568) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08333. On Jul 30, 2012 this sequence version replaced NP_011757.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..568 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..568 /product="Yap1802p" /calculated_mol_wt="64197" Region 5..263 /region_name="ANTH" /note="ANTH domain; pfam07651" /db_xref="CDD:400137" Site order(11,21,23..24) /site_type="other" /note="putative PtdIns(4,5)P2-binding site [chemical binding]" /db_xref="CDD:340785" CDS 1..568 /gene="YAP1802" /locus_tag="YGR241C" /coded_by="NM_001181370.3:1..1707" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:33443082]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:physical interaction:GO:0006897 endocytosis [PMID:9531549]" /note="Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1802 has a paralog, YAP1801, that arose from the whole genome duplication" /db_xref="GeneID:853157" /db_xref="SGD:S000003473" ORIGIN 1 msslytklvk gatkikmapp kqkyvdpils gtssarglqe ithaldirls dtawtivyka 61 livlhlmiqq gekdvtlrhy shnldvfqlr kishttkwss ndmralqryd eylktrceey 121 grlgmdhlrd nysslklgsk nqlsmdeeld hvesleiqin alirnkysvs dlenhlllya 181 fqllvqdllg lynalnegvi tllesffels iehakrtldl ykdfvdmtey vvrylkigka 241 vglkipvikh ittklinsle ehlreetkrq rgepsepqqd rkpstaisst sshnnnsndk 301 nksiaqkkle qireqkrlle qqlqnqqlli sptvpqdayn pfgsqqqdln ndtfsfeptq 361 pqmtaqvpqp tanpflipqq qqqalqltsa stmpqpseiq itpnlnnqqt gmyasnlqyt 421 pnftgsgfgg ytttennaim tgtldptktg snnpfsleni areqqqqnfq nspnpftlqq 481 aqttpilahs qtgnpfqaqn vvtspmgtym tnpvagqlqy astgaqqqpq mmqgqqtgyv 541 mvptafvpin qqqqqqqhqq enpnlidi // LOCUS NP_011759 146 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial pyruvate carrier [Saccharomyces cerevisiae S288C]. ACCESSION NP_011759 VERSION NP_011759.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181372.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08334. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..146 /product="mitochondrial pyruvate carrier" /calculated_mol_wt="16099" Region 9..118 /region_name="MPC" /note="Mitochondrial pyruvate carriers; pfam03650" /db_xref="CDD:427425" CDS 1..146 /gene="MPC3" /locus_tag="YGR243W" /gene_synonym="FMP43" /coded_by="NM_001181372.1:1..441" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006850 pyruvate import into mitochondria [PMID:25672363]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:22628558]" /experiment="EXISTENCE:direct assay:GO:0050833 pyruvate transmembrane transporter activity [PMID:25672363]" /experiment="EXISTENCE:mutant phenotype:GO:0006850 pyruvate import into mitochondria [PMID:22628554]" /experiment="EXISTENCE:mutant phenotype:GO:0050833 pyruvate transmembrane transporter activity [PMID:22628554]" /note="Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC3 paralog, MPC2, heterodimerizes with Mpc1p to form the fermentative MPC isoform; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853158" /db_xref="SGD:S000003475" ORIGIN 1 msasafnfaf rrfwnsetgp ktvhfwaptl kwglvfagln dikrpvekvs gaqnlsllat 61 aliwtrwsfv ikpknyllas vnfflgctag yhltrianfr irngdsfkqv ihyiikgetp 121 aavaakqtas tsmnkgvigt nppith // LOCUS NP_011760 427 aa linear PLN 30-JUN-2025 DEFINITION succinate--CoA ligase (GDP-forming) subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_011760 VERSION NP_011760.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181373.3 REFERENCE 1 (residues 1 to 427) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 427) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 427) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 427) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08335. On Jul 30, 2012 this sequence version replaced NP_011760.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..427 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..427 /product="succinate--CoA ligase (GDP-forming) subunit beta" /EC_number="6.2.1.5" /calculated_mol_wt="46770" Region 33..427 /region_name="SucC" /note="Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; COG0045" /db_xref="CDD:439815" CDS 1..427 /gene="LSC2" /locus_tag="YGR244C" /coded_by="NM_001181373.3:1..1284" /experiment="EXISTENCE:direct assay:GO:0004775 succinate-CoA ligase (ADP-forming) activity [PMID:9874242]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9874242|PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006104 succinyl-CoA metabolic process [PMID:9874242]" /experiment="EXISTENCE:mutant phenotype:GO:0004775 succinate-CoA ligase (ADP-forming) activity [PMID:9874242]" /note="Beta subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate" /db_xref="GeneID:853159" /db_xref="SGD:S000003476" ORIGIN 1 mysrkslsli skcgqlsrln aqaalqarrh lsiheyrsaq llreygigtp egfpaftpee 61 afeaakklnt nklvikaqal tggrgkghfd tgyksgvhmi espqqaedva kemlnhnlit 121 kqtgiagkpv savyivkrvd tkheaylsil mdrqtkkpmi iassqggmni eevaertpda 181 ikkfsietsk glspqmakdv akslgfspda qdeaakavsn lykifmerda tqveinplse 241 iehdpthkim ctdakfgfdd nasfrqekiy swrdlsqedp devkakkydl nfvklkgnig 301 clvngaglam atmdviklng gdpanfldcg ggatpetikq gfelilsnkn vdaifvnifg 361 givrcdyval glveaarele vrvpivarlq gtkveegrdi inksgvkiys fdeldpaakk 421 vveltqn // LOCUS NP_011761 767 aa linear PLN 30-JUN-2025 DEFINITION Sda1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011761 VERSION NP_011761.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181374.3 REFERENCE 1 (residues 1 to 767) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 767) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 767) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 767) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08336. On Jul 30, 2012 this sequence version replaced NP_011761.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..767 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..767 /product="Sda1p" /calculated_mol_wt="86488" Region 93..142 /region_name="NUC130_3NT" /note="NUC130/3NT domain; pfam08158" /db_xref="CDD:462384" Region 459..765 /region_name="SDA1" /note="pfam05285" /db_xref="CDD:461611" CDS 1..767 /gene="SDA1" /locus_tag="YGR245C" /coded_by="NM_001181374.3:1..2304" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10704371]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:15107621]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:11160833]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:15107621]" /note="Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis" /db_xref="GeneID:853160" /db_xref="SGD:S000003477" ORIGIN 1 mgrrsraaml ptniillqnl vkrdpesyqe eflqqyahye slrdifmlng laggdsaaat 61 ngldvgngss tmagtngttm ststsqliel vgfvsqvcsc fpretanfps elkqlllehh 121 kslpfelkek ilscltmlrn kdvitaeeli qslfpllvay sshgnslgvn shakelrkii 181 ytnlisllks cntngknqkl nkstqavcfn lldqpdsqgi watkltrelw rrgiwddsrt 241 veimtqaalh qdvkivmsgv mffldadrer eenfeensed edgfdldalr hkmqvnkktg 301 rrgkklenai ktvkkkkkng pgapqgylnf saihllrdpq gfaeklfkeh lsgktknkfd 361 meqkislmql lsrligthkl ivlgiytffl kyltpkqrdv trimsacaqa chdlvppevi 421 nvmvrkiade fvsdgvanev aaagintire icsraplaid eillqdlvey kgskakgvnm 481 aakslialyr dvapemlkkk drgknaamev qeakkggkds krpqfgadns vqgiagiell 541 akwkkehgee senedadanw evdvdseedd vdgewvtmds dkeydvdmed sddekdnakg 601 kesdsdlels ddddekevkd eqedadidpe aafreiastr iltpadfakl qelrneesva 661 kimgihkqdk reelvdastl tgpikykqsr eerlqkvleg regrdkfgsr rgkrdnmrst 721 tnrekerrkn fvmsihkrsv rgkqkmslrd kqkvlrahit kqkkkgy // LOCUS NP_011762 596 aa linear PLN 30-JUN-2025 DEFINITION transcription factor TFIIIB subunit BRF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011762 VERSION NP_011762.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181375.1 REFERENCE 1 (residues 1 to 596) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 596) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 596) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 596) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 596) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08337. Method: conceptual translation. FEATURES Location/Qualifiers source 1..596 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..596 /product="transcription factor TFIIIB subunit BRF1" /calculated_mol_wt="66776" Region 3..45 /region_name="TF_Zn_Ribbon" /note="TFIIB zinc-binding; pfam08271" /db_xref="CDD:400527" Region 78..168 /region_name="CYCLIN_TFIIIB90_rpt1" /note="first cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins; cd20553" /db_xref="CDD:410256" Site order(79,118..121,155,159,162..163) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:410256" Region 174..265 /region_name="CYCLIN_TFIIIB90_rpt2" /note="second cyclin box found in transcription factor IIIB 90 kDa subunit (TFIIIB90) and similar proteins; cd20554" /db_xref="CDD:410257" Site order(217..219,250..251,253..254) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:410257" Region 463..595 /region_name="BRF1" /note="Brf1-like TBP-binding domain; pfam07741" /db_xref="CDD:462250" CDS 1..596 /gene="BRF1" /locus_tag="YGR246C" /gene_synonym="PCF4; TDS4" /coded_by="NM_001181375.1:1..1791" /experiment="EXISTENCE:direct assay:GO:0000126 transcription factor TFIIIB complex [PMID:1423590|PMID:1458536]" /experiment="EXISTENCE:direct assay:GO:0000994 RNA polymerase III core binding [PMID:7995525|PMID:9689057]" /experiment="EXISTENCE:direct assay:GO:0001156 TFIIIC-class transcription factor complex binding [PMID:12930823]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:9271407]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:15190063]" /experiment="EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11387215]" /experiment="EXISTENCE:mutant phenotype:GO:0001112 DNA-templated transcription open complex formation [PMID:11387215]" /experiment="EXISTENCE:mutant phenotype:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11387215|PMID:9218475|PMID:9710642]" /experiment="EXISTENCE:physical interaction:GO:0000994 RNA polymerase III core binding [PMID:7995525]" /experiment="EXISTENCE:physical interaction:GO:0001156 TFIIIC-class transcription factor complex binding [PMID:12930823]" /note="TFIIIB B-related factor; one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB; mutations in human homolog are associated with autosomal recessive cerebellar-facial-dental syndrome" /db_xref="GeneID:853161" /db_xref="SGD:S000003478" ORIGIN 1 mpvcknchgt eferdlsnan ndlvckacgv vsednpivse vtfgetsaga avvqgsfiga 61 gqshaafggs salesreatl nnarrklrav syalhipeyi tdaafqwykl alannfvqgr 121 rsqnviascl yvacrkekth hmlidfssrl qvsvysigat flkmvkklhi telpladpsl 181 fiqhfaekld ladkkikvvk davklaqrms kdwmfegrrp agiagacill acrmnnlrrt 241 hteivavshv aeetlqqrln efkntkaakl svqkfrendv edgearppsf vknrkkerki 301 kdsldkeemf qtseealnkn piltqvlgeq elsskevlfy lkqfserrar vverikatng 361 idgeniyheg senetrkrkl sevsiqnehv egedketegt eekvkkvktk tseekkenes 421 ghfqdaidgy sletdpycpr nlhllpttdt ylskvsddpd nledvddeel nahllneeas 481 klkeriwigl nadflleqes krlkqeadia tgntsvkkkr trrrnntrsd eptktvdaaa 541 aiglmsdlqd ksglhaalka aeesgdftta dsvknmlqka sfskkinyda idglfr // LOCUS NP_011763 239 aa linear PLN 30-JUN-2025 DEFINITION 2',3'-cyclic-nucleotide 3'-phosphodiesterase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011763 VERSION NP_011763.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181376.1 REFERENCE 1 (residues 1 to 239) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 239) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 239) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 239) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08338. Method: conceptual translation. FEATURES Location/Qualifiers source 1..239 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..239 /product="2',3'-cyclic-nucleotide 3'-phosphodiesterase" /EC_number="3.1.4.37" /calculated_mol_wt="26601" Region 1..239 /region_name="CPDase" /note="Cyclic phosphodiesterase-like protein; pfam07823" /db_xref="CDD:311669" CDS 1..239 /gene="CPD1" /locus_tag="YGR247W" /coded_by="NM_001181376.1:1..720" /experiment="EXISTENCE:direct assay:GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [PMID:10734185]" /experiment="EXISTENCE:direct assay:GO:0009187 cyclic nucleotide metabolic process [PMID:10734185]" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [PMID:10734185]" /note="Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853162" /db_xref="SGD:S000003479" ORIGIN 1 maialwycpp qgsvayetlq mlifsfqtlf pdspvfephv tvtshlvcns kddvnkilts 61 cvaaiqsirs hqtakkgrkg qvshavaapl vsfngcsvgk qyfkkivlec nknkilygva 121 qvmremyvei dpetrssraa twvheefhph vsllysdihp vsqaslrvvq qriedaldvq 181 lvprekrkgs gnadgsnevq mrwdfdvsss lswnipgtfk vvncvgpvqe wevlgrvdv // LOCUS NP_011764 255 aa linear PLN 30-JUN-2025 DEFINITION 6-phosphogluconolactonase SOL4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011764 VERSION NP_011764.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181377.3 REFERENCE 1 (residues 1 to 255) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 255) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 255) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 255) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08339. On Jul 30, 2012 this sequence version replaced NP_011764.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..255 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..255 /product="6-phosphogluconolactonase SOL4" /EC_number="3.1.1.31" /calculated_mol_wt="28317" Region 8..241 /region_name="Glucosamine_iso" /note="Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase; pfam01182" /db_xref="CDD:460101" CDS 1..255 /gene="SOL4" /locus_tag="YGR248W" /coded_by="NM_001181377.3:1..768" /experiment="EXISTENCE:curator inference:GO:0009051 pentose-phosphate shunt, oxidative branch [PMID:15454531]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15454531]" /experiment="EXISTENCE:genetic interaction:GO:0017057 6-phosphogluconolactonase activity [PMID:15454531]" /note="6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication" /db_xref="GeneID:853163" /db_xref="SGD:S000003480" ORIGIN 1 mvklqrfsek kslihefgkf ilekqesalt gdadavfnia isggsmnqal yeslvndkni 61 fphikwpqwr iffcderlvp fedpqsnygq fkktvldplv hqgnqlnlgp tvytinesli 121 gggetanrki aeeyasmlpa sfdlillgcg edghtcslfp gvefnylvee mdrkvlwcnn 181 spkapkdrit ftlavvaeak svcflvrgaa kkaimhdvli vknselpsvl vnemvgtkvt 241 wflddeagal ipenc // LOCUS NP_011765 456 aa linear PLN 30-JUN-2025 DEFINITION Mga1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011765 VERSION NP_011765.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181378.1 REFERENCE 1 (residues 1 to 456) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 456) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 456) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 456) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08340. Method: conceptual translation. FEATURES Location/Qualifiers source 1..456 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..456 /product="Mga1p" /calculated_mol_wt="50604" Region 1..>156 /region_name="HSF1" /note="Heat shock transcription factor [Transcription]; COG5169" /db_xref="CDD:227497" CDS 1..456 /gene="MGA1" /locus_tag="YGR249W" /coded_by="NM_001181378.1:1..1371" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16449570]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:9832522]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9832522]" /note="Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants" /db_xref="GeneID:853164" /db_xref="SGD:S000003481" ORIGIN 1 mqpktfvhql haillepevn kwiywsptdn tvfflkpydp nfsthvlkry fkhgnvnsfv 61 rqlhmygfhk lshpspdqss anngnvkelv ewkfthpsgf ffkeanagil nkiqrkstgv 121 gkdgkrknil spisvsyvda srlnvlsqqs gpvsarepsn mfmgspvhys tsqspphisi 181 pqqqqssgpy lisslppqqp tvnmmrrqsi sarmmnsydy pnqfstqdsi vqpqqpqqvl 241 spqalsgppm kksgtlsstd dlkttslpiv nypmpyhpga faqqqqqqqq plptvppyss 301 ystpfpsmmn slsnsasnsp algvcnnnvt lpkksniser qaldnhiqtl knslstitdl 361 iekhinsasq denktltnda mnkdlrtsls llqnskeeii qleskwmsmq svkttalplq 421 ettntsstlt sltssiipks ipiitkgeva tkpasy // LOCUS NP_011766 781 aa linear PLN 30-JUN-2025 DEFINITION Rie1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011766 VERSION NP_011766.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181379.3 REFERENCE 1 (residues 1 to 781) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 781) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 781) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 781) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 781) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 781) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 781) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 781) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08341. On Jul 30, 2012 this sequence version replaced NP_011766.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..781 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..781 /product="Rie1p" /calculated_mol_wt="89382" Region 195..757 /region_name="PABP-1234" /note="polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628" /db_xref="CDD:130689" Region 542..634 /region_name="RRM3_CELF1-6" /note="RNA recognition motif 3 (RRM3) found in CELF/Bruno-like family of RNA binding proteins CELF1, CELF2, CELF3, CELF4, CELF5, CELF6 and similar proteins; cd12362" /db_xref="CDD:409797" CDS 1..781 /gene="RIE1" /locus_tag="YGR250C" /gene_synonym="WHI8" /coded_by="NM_001181379.3:1..2346" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:26777405]" /experiment="EXISTENCE:physical interaction:GO:2000134 negative regulation of G1/S transition of mitotic cell cycle [PMID:33480968]" /note="RNA binding protein and negative regulator of START; binds mRNA of the G1 cyclin CLN3 to stress granules for translational repression under conditions of stress; recruits the cyclin-dependent protein kinase Cdc28p to stress granules when stressful conditions are relieved, resulting in the dissolution of the granules, and resumption of translation; localizes to stress granules induced by glucose deprivation; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853165" /db_xref="SGD:S000003482" ORIGIN 1 mniaeepsde vissgpedtd icsqqtsasa eagdqsikie rktstglqle qlantnllti 61 rikwqlqeee ddhcnsritd qimdtiqhyk gisvnnsdte tyeflpdtrr lqvleqnkdi 121 ylyehgsqey eksykdneee ddwrydtvlq aqfkypksle nactdisell ksepigqhid 181 kwsigvnkha ltypgnifvg giakslsige lsflfskygp ilsmkliydk tkgepngygf 241 isyplgsqas lcikelngrt vngstlfiny hverkereri hwdhvkennn ddnfrclfig 301 nlpyhnpekv etlitpkevi evikkelskk fpdfdiisyy fpkrsntrss ssvsfneegs 361 vesnkssnnt ngnaqdedml kgygfiklin heqalaaiet fngfmwhgnr lvvnkavqhk 421 vynnhnshdr hpsisnhndm evlefannpm ydynnytydr yyfnnnkngn sndtsnvryf 481 dsvrstpvae kmdlfypqre sfsegrgqrv prfmgnkfdm yqypstsysl pipmsnqqes 541 nlyvkhipls wtdedlydfy ksfgeiisvk vitvggsknk yrqqsndsss dndlpvgssr 601 gygfvsfesp ldaakailnt dgyqvskdqv lsvsfaqkrg nlsssddddq sqtdnsskfq 661 nfqphndyhk ayptkynkkf inalmtqnqs qqqvsrenyf iplqypntnt kpvnsynlis 721 anqnnanwmm pmfpsfgfip qvppvpyiip pqnpaanhip imangsneee efssgdysmd 781 y // LOCUS NP_011767 196 aa linear PLN 30-JUN-2025 DEFINITION Nop19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011767 VERSION NP_011767.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181380.3 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08342. On Jul 30, 2012 this sequence version replaced NP_011767.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..196 /product="Nop19p" /calculated_mol_wt="22189" Region 1..149 /region_name="NOP19" /note="Nucleolar protein 19; pfam10863" /db_xref="CDD:402465" CDS 1..196 /gene="NOP19" /locus_tag="YGR251W" /coded_by="NM_001181380.3:1..591" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:19159085|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:21941128]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:21941128|PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:21941128]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:21941128]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12837249]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:21941128]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:21941128]" /note="Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes" /db_xref="GeneID:853166" /db_xref="SGD:S000003483" ORIGIN 1 msrakelqek lnlqaklqst fsnntaavld wlkesdetgi sndternkql kdhkeledgk 61 kaffklpvlq igsglhfrtq ddasakedih tigefiegdk kvsslakkkk rsdpglqrnn 121 myritkddtk amialkrkmr kgekeglrkk qehskssvsn sysasdeede dagtmpqkst 181 kkkfgllfdk kkkark // LOCUS NP_011768 439 aa linear PLN 30-JUN-2025 DEFINITION histone acetyltransferase GCN5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011768 VERSION NP_011768.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181381.1 REFERENCE 1 (residues 1 to 439) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 439) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 439) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 439) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08343. Method: conceptual translation. FEATURES Location/Qualifiers source 1..439 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..439 /product="histone acetyltransferase GCN5" /EC_number="2.3.1.48" /calculated_mol_wt="50938" Region 77..439 /region_name="COG5076" /note="Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]" /db_xref="CDD:227408" CDS 1..439 /gene="GCN5" /locus_tag="YGR252W" /gene_synonym="AAS104; ADA4; KAT2; SWI9" /coded_by="NM_001181381.1:1..1320" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9224714|PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:18039853]" /experiment="EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:31699900]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:8601308]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0010484 histone H3 acetyltransferase activity [PMID:18458063]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:direct assay:GO:0140011 histone H4K12ac reader activity [PMID:20126658]" /experiment="EXISTENCE:direct assay:GO:0140046 histone H4K16ac reader activity [PMID:20126658]" /experiment="EXISTENCE:direct assay:GO:0140068 histone crotonyltransferase activity [PMID:31699900]" /experiment="EXISTENCE:direct assay:GO:0140129 histone H3K56ac reader activity [PMID:20126658]" /experiment="EXISTENCE:direct assay:GO:0140671 ADA complex [PMID:10490601|PMID:7862114]" /experiment="EXISTENCE:genetic interaction:GO:0010484 histone H3 acetyltransferase activity [PMID:18458063]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:19822662]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:11867538]" /experiment="EXISTENCE:mutant phenotype:GO:0010484 histone H3 acetyltransferase activity [PMID:18458063]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:19822662]" /note="Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation" /db_xref="GeneID:853167" /db_xref="SGD:S000003484" ORIGIN 1 mvtkhqieed hldgattdpe vkrvklennv eeiqpeqaet nkqegtdken kgkfeketer 61 iggsevvtdv ekgivkfefd gveytfkerp svveenegki efrvvnndnt kenmmvltgl 121 knifqkqlpk mpkeyiarlv ydrshlsmav irkpltvvgg ityrpfdkre faeivfcais 181 steqvrgyga hlmnhlkdyv rntsnikyfl tyadnyaigy fkkqgftkei tldksiwmgy 241 ikdyeggtlm qcsmlpriry ldagkilllq eaalrrkirt iskshivrpg leqfkdlnni 301 kpidpmtipg lkeagwtpem dalaqrpkrg phdaaiqnil telqnhaaaw pflqpvnkee 361 vpdyydfike pmdlstmeik lesnkyqkme dfiydarlvf nncrmyngen tsyykyanrl 421 ekffnnkvke ipeyshlid // LOCUS NP_011769 260 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit alpha 5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011769 VERSION NP_011769.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181382.1 REFERENCE 1 (residues 1 to 260) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 260) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 260) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 260) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08344. Method: conceptual translation. FEATURES Location/Qualifiers source 1..260 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..260 /product="proteasome core particle subunit alpha 5" /calculated_mol_wt="28486" Region 8..222 /region_name="proteasome_alpha_type_5" /note="The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming...; cd03753" /db_xref="CDD:239722" Site order(10..13,15..16,18..19,23,26,29..30,33,41,56,58..59, 82..84,86..87,118,121,124..125,134..138,156,161..162,164, 166..167,169) /site_type="other" /note="alpha subunit interaction site [polypeptide binding]" /db_xref="CDD:239722" Site order(35,51,53,66,174) /site_type="active" /db_xref="CDD:239722" CDS 1..260 /gene="PUP2" /locus_tag="YGR253C" /gene_synonym="DOA5" /coded_by="NM_001181382.1:1..783" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019773 proteasome core complex, alpha-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /note="Alpha 5 subunit of the 20S proteasome; involved in ubiquitin-dependent catabolism; human homolog is subunit zeta" /db_xref="GeneID:853168" /db_xref="SGD:S000003485" ORIGIN 1 mfltrseydr gvstfspegr lfqveyslea iklgstaigi atkegvvlgv ekratsplle 61 sdsiekivei drhigcamsg ltadarsmie hartaavthn lyydedinve sltqsvcdla 121 lrfgegasge erlmsrpfgv alliaghdad dgyqlfhaep sgtfyrynak aigsgsegaq 181 aellnewhss ltlkeaellv lkilkqvmee kldennaqls citkqdgfki ydnektaeli 241 kelkekeaae speeadvems // LOCUS NP_011770 437 aa linear PLN 30-JUN-2025 DEFINITION phosphopyruvate hydratase ENO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011770 VERSION NP_011770.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181383.3 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08345. On Jul 30, 2012 this sequence version replaced NP_011770.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..437 /product="phosphopyruvate hydratase ENO1" /EC_number="4.2.1.11" /calculated_mol_wt="46685" Region 1..430 /region_name="PTZ00081" /note="enolase; Provisional" /db_xref="CDD:240259" CDS 1..437 /gene="ENO1" /locus_tag="YGR254W" /gene_synonym="HSP48" /coded_by="NM_001181383.3:1..1314" /experiment="EXISTENCE:direct assay:GO:0000015 phosphopyruvate hydratase complex [PMID:6282834]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16565073]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:16565073]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:mutant phenotype:GO:0004634 phosphopyruvate hydratase activity [PMID:6282834]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:6282834]" /experiment="EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:16565073]" /note="Enolase I, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression repressed in response to glucose; protein abundance increases in response to DNA replication stress; N-terminally propionylated in vivo; ENO1 has a paralog, ENO2, that arose from the whole genome duplication" /db_xref="GeneID:853169" /db_xref="SGD:S000003486" ORIGIN 1 mavskvyars vydsrgnptv evelttekgv frsivpsgas tgvhealemr dgdkskwmgk 61 gvlhavknvn dviapafvka nidvkdqkav ddflisldgt anksklgana ilgvslaasr 121 aaaaeknvpl ykhladlsks ktspyvlpvp flnvlnggsh aggalalqef miaptgaktf 181 aealrigsev yhnlksltkk rygasagnvg deggvapniq taeealdliv daikaaghdg 241 kikigldcas seffkdgkyd ldfknpnsdk skwltgpqla dlyhslmkry pivsiedpfa 301 eddweawshf fktagiqiva ddltvtnpkr iataiekkaa dalllkvnqi gtlsesikaa 361 qdsfaagwgv mvshrsgete dtfiadlvvg lrtgqiktga parserlakl nqllrieeel 421 gdnavfagen fhhgdkl // LOCUS NP_011771 479 aa linear PLN 30-JUN-2025 DEFINITION putative N,N-dimethylaniline monooxygenase COQ6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011771 VERSION NP_011771.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181384.1 REFERENCE 1 (residues 1 to 479) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 479) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 479) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 479) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08346. Method: conceptual translation. FEATURES Location/Qualifiers source 1..479 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..479 /product="putative N,N-dimethylaniline monooxygenase COQ6" /calculated_mol_wt="53397" Region 28..471 /region_name="COQ6" /note="ubiquinone biosynthesis monooxygenase COQ6; TIGR01989" /db_xref="CDD:273914" CDS 1..479 /gene="COQ6" /locus_tag="YGR255C" /coded_by="NM_001181384.1:1..1440" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12721307]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:9266513|PMID:21944752]" /experiment="EXISTENCE:mutant phenotype:GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [PMID:21944752]" /note="Flavin-dependent monooxygenase involved in ubiquinone biosynthesis; responsible for hydroxylation at position C5 and deamination at C4 during ubiquinone (Coenzyme Q) biosynthesis; localizes to matrix face of mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human homolog COQ6 can complement yeast null mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)" /db_xref="GeneID:853170" /db_xref="SGD:S000003487" ORIGIN 1 mffskvmltr rilvrglata kssapkltdv livgggpagl tlaasiknsp qlkdlkttlv 61 dmvdlkdkls dfynsppdyf tnrivsvtpr sihflennag atlmhdriqs ydglyvtdgc 121 skatldlard smlcmieiin iqaslynris qydskkdsid iidntkvvni khsdpndpls 181 wplvtlsnge vyktrllvga dgfnsptrrf sqipsrgwmy naygvvasmk leyppfklrg 241 wqrflptgpi ahlpmpenna tlvwssserl srlllslppe sftalinaaf vledadmnyy 301 yrtledgsmd tdkliedikf rteeiyatlk desdideiyp prvvsiidkt rarfplklth 361 adryctdrva lvgdaahtth plagqglnmg qtdvhglvya lekamergld igsslslepf 421 waerypsnnv llgmadklfk lyhtnfppvv alrtfglnlt nkigpvknmi idtlggnek // LOCUS NP_011772 492 aa linear PLN 30-JUN-2025 DEFINITION phosphogluconate dehydrogenase (decarboxylating) GND2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011772 VERSION NP_011772.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181385.3 REFERENCE 1 (residues 1 to 492) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 492) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 492) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 492) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08347. On Jul 30, 2012 this sequence version replaced NP_011772.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..492 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..492 /product="phosphogluconate dehydrogenase (decarboxylating) GND2" /EC_number="1.1.1.44" /calculated_mol_wt="53792" Region 7..480 /region_name="gnd" /note="6-phosphogluconate dehydrogenase (decarboxylating); TIGR00873" /db_xref="CDD:273314" CDS 1..492 /gene="GND2" /locus_tag="YGR256W" /coded_by="NM_001181385.3:1..1479" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:mutant phenotype:GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity [PMID:1328471]" /experiment="EXISTENCE:mutant phenotype:GO:0009051 pentose-phosphate shunt, oxidative branch [PMID:1328471]" /note="6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication" /db_xref="GeneID:853172" /db_xref="SGD:S000003488" ORIGIN 1 mskavgdlgl vglavmgqnl ilnaadhgft vvaynrtqsk vdrflaneak gksiigatsi 61 edlvaklkkp rkimllikag apvdtlikel vphldkgdii idggnshfpd tnrryeeltk 121 qgilfvgsgv sggedgarfg pslmpggsae awphiknifq siaaksngep ccewvgpags 181 ghyvkmvhng ieygdmqlic eaydimkrig rftdkeisev fdkwntgvld sflieitrdi 241 lkfddvdgkp lvekimdtag qkgtgkwtai naldlgmpvt ligeavfarc lsaikderkr 301 askllagptv pkdaihdreq fvydleqaly askiisyaqg fmlireaars ygwklnnpai 361 almwrggcii rsvflaeitk ayrddpdlen llfneffasa vtkaqsgwrr tialaatygi 421 ptpafstala fydgyrserl panllqaqrd yfgahtfril pecasahlpv dkdihinwtg 481 hggnisssty qa // LOCUS NP_011773 366 aa linear PLN 30-JUN-2025 DEFINITION Mtm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011773 VERSION NP_011773.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181386.3 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08348. On Jul 30, 2012 this sequence version replaced NP_011773.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..366 /product="Mtm1p" /calculated_mol_wt="40632" Region 14..149 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 154..255 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 264..364 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..366 /gene="MTM1" /locus_tag="YGR257C" /coded_by="NM_001181386.3:1..1101" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:12890866]" /experiment="EXISTENCE:direct assay:GO:0030170 pyridoxal phosphate binding [PMID:24184947]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:16601688]" /experiment="EXISTENCE:mutant phenotype:GO:0031921 pyridoxal phosphate transport [PMID:25637770]" /note="Mitochondrial protein of the mitochondrial carrier family; high affinity pyridoxal 5'-phosphate (PLP) transporter, important for delivery of the PLP cofactor to mitochondrial enzymes; involved in mitochondrial iron homeostasis" /db_xref="GeneID:853173" /db_xref="SGD:S000003489" ORIGIN 1 msdrntsnsl tlkermlsag agsvltslil tpmdvvrirl qqqqmipdcs cdgaaevpna 61 vssgskmktf tnvggqnlnn akifwesacf qelhcknssl kfngtleaft kiasvegits 121 lwrgisltll maipanmvyf sgyeyirdvs piastyptln plfcgaiarv faatsiaple 181 lvktklqsip rsskstktwm mvkdllnetr qemkmvgpsr alfkgleitl wrdvpfsaiy 241 wssyelcker lwldstrfas kdanwvhfin sfasgcisgm iaaicthpfd vgktrwqism 301 mnnsdpkggn rsrnmfkfle tiwrteglaa lytglaarvi kirpscaimi ssyeiskkvf 361 gnklhq // LOCUS NP_011774 1031 aa linear PLN 30-JUN-2025 DEFINITION ssDNA endodeoxyribonuclease RAD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011774 VERSION NP_011774.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181387.1 REFERENCE 1 (residues 1 to 1031) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1031) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1031) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1031) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1031) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1031) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1031) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1031) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08349. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1031 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1031 /product="ssDNA endodeoxyribonuclease RAD2" /calculated_mol_wt="117707" Region 1..1030 /region_name="rad2" /note="DNA excision repair protein (rad2); TIGR00600" /db_xref="CDD:273166" CDS 1..1031 /gene="RAD2" /locus_tag="YGR258C" /coded_by="NM_001181387.1:1..3096" /experiment="EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:8247134]" /experiment="EXISTENCE:direct assay:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:8855246]" /experiment="EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:7926735]" /experiment="EXISTENCE:genetic interaction:GO:0006366 transcription by RNA polymerase II [PMID:12110180]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:7926735]" /note="Single-stranded DNA endonuclease; cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein" /db_xref="GeneID:853174" /db_xref="SGD:S000003490" ORIGIN 1 mgvhsfwdia gptarpvrle sledkrmavd asiwiyqflk avrdqegnav knshitgffr 61 rickllyfgi rpvfvfdggv pvlkretirq rkerrqgkre sakstarkll alqlqngsnd 121 nvknstpssg ssvqifkpqd ewdlpdipgf kydkedarvn snktfeklmn singdgledi 181 dldtinpasa efeelpkatq ylilsslrlk srlrmgyske qletifpnsm dfsrfqidmv 241 krrnfftqkl inttgfqdgg asklneevin risgqkskey kltktnngwi lglgandgsd 301 aqkaividdk dagalvkqld snaedgdvlr wddlednslk ivrhessnat tapqkrsnrs 361 edegcdsdec eweevelkpk nvkfvedfsl kaarlpymgq slnnagsksf ldkrhdqasp 421 skttptmris risveddded ylkqieeiem meavqlskme kkpeaddksk iakpvtskgt 481 earppivqyg llgaqpdskq pyhvtnlnsk sesvikrtsk tvlsefrpps qqedkgailt 541 egeqnlnfis hkipqfdfnn ensllfqknt esnvsqeatk ekspipemps wfsstasqql 601 ynpynttnfv edknvrneqe sgaettnkgs syelltglna teileresek essndenkdd 661 dlevlseelf edvptksqis keaedndsrk vesinkehrk plifdydfse deednivenm 721 ikeqeefdtf knttlstsae rnvaenafve delfeqqmkd krdsdevtmd mikevqells 781 rfgipyitap meaeaqcael lqlnlvdgii tddsdvflfg gtkiyknmfh eknyvefyda 841 esilkllgld rknmielaql lgsdytnglk gmgpvssiev iaefgnlknf kdwynngqfd 901 krkqetenkf ekdlrkklvn neiildddfp svmvydaymr pevdhdttpf vwgvpdldml 961 rsfmktqlgw pheksdeili plirdvnkrk kkgkqkrine ffpreyisgd kklntskris 1021 tatgklkkrk m // LOCUS NP_011776 534 aa linear PLN 30-JUN-2025 DEFINITION Tna1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011776 VERSION NP_011776.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181389.1 REFERENCE 1 (residues 1 to 534) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 534) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 534) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 534) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08350. Method: conceptual translation. FEATURES Location/Qualifiers source 1..534 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..534 /product="Tna1p" /calculated_mol_wt="60004" Region 87..490 /region_name="MFS_FEN2_like" /note="Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; cd17327" /db_xref="CDD:340885" Site order(103..104,107..108,111,144,194..195,197..199,202,222, 225..226,229,326,329..330,333..335,338,365,369,419..420, 424,428,445,448..449,452..453,456) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340885" CDS 1..534 /gene="TNA1" /locus_tag="YGR260W" /coded_by="NM_001181389.1:1..1605" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:34498791]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:34498791]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:34498791]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0046942 carboxylic acid transport [PMID:10869563]" /experiment="EXISTENCE:mutant phenotype:GO:0046943 carboxylic acid transmembrane transporter activity [PMID:10869563]" /experiment="EXISTENCE:mutant phenotype:GO:1903222 quinolinic acid transmembrane transport [PMID:23457190]" /note="High affinity nicotinic acid plasma membrane permease; responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA)" /db_xref="GeneID:853175" /db_xref="SGD:S000003492" ORIGIN 1 msnkftmesp khlvddvlfi sptndgseek ptevtfqede ghdaslhnrs hdkkselate 61 reimatttdd dgipspshpm ekrvlrkmdi yliplmgmly flsnldksni gnaevaglsk 121 dihlvgtqyn tcvtvffaty vlfdpigtnl lkimgpplmm sicltcfgai slgtawvkny 181 aqlivvrlll gafegmiypa inmylsvcyr reqyalrfaf vfsaaclsss fggliaygcs 241 kisgslkdwq yiyivegcis lgfvpfyafg lsknledswf fnkeekeyis eryktmntfd 301 pdekfewfqv wqavkdvktw asavalfgid lttfgltvfl piiitsmgft nvraqlmtvp 361 iyfltaivff icavwsdrik lrspfilgac lttsigiaiv lgsqvhgvry fgvyilcmgi 421 yvnaacnclw lsgntgnyfk ratalginlf fgsgsglvsg qifvakdkpr yikglsisla 481 fqvfsifmtv vqiflykren dkkkaiidrc nelgepipyd erlsdknpef kymy // LOCUS NP_011777 809 aa linear PLN 30-JUN-2025 DEFINITION AP-3 complex subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_011777 VERSION NP_011777.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181390.3 REFERENCE 1 (residues 1 to 809) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 809) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 809) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 809) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08351. On Jul 30, 2012 this sequence version replaced NP_011777.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..809 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..809 /product="AP-3 complex subunit beta" /calculated_mol_wt="91476" Region 6..770 /region_name="COG5096" /note="Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]" /db_xref="CDD:227427" Region 45..69 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 119..146 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 153..182 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..809 /gene="APL6" /locus_tag="YGR261C" /gene_synonym="YKS5" /coded_by="NM_001181390.3:1..2430" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:17895371]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:9335339]" /experiment="EXISTENCE:mutant phenotype:GO:0030123 AP-3 adaptor complex [PMID:9250663]" /note="Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools" /db_xref="GeneID:853177" /db_xref="SGD:S000003493" ORIGIN 1 mvdsihrias aldtakvitr eaaavatskl gessytyysq ninpqqlvtl lnsrnsrevr 61 damkriisim asdddsidvq lyfadvvkni ttndtkvkrl ihlyllrfae ndpnltllsi 121 nslqkslsds nselrcfals alsdmkmssl apiilhtvkk lvtdpsamvr gevalaiikl 181 yragkndyhe elldilkelm adtdpkvisc avlaykecya dhlellhghf rrycriikql 241 dswsqsylie llikyckqyl pkptvvdkss egsprscplp dkyneieyps yevvndpdld 301 lflqslncli yssnptvils ccnalyqlas plqmkntkfi ealvrtvtmt enqgnkemll 361 qaihflsild qtlflpytkk fyvfpkdpiv asiwkiqils tlinesnvke ifkelkyyva 421 sahfpenvvi mavkslsrcg qlstsweshv mkwlidhmes hnlsasvlda yvnvirmlvq 481 knptkhlrii fkladlltvq tsladnarag ivwlfgeias iefkicpdvl rrliqnfsne 541 gpetrcqilv lsakllsydi dnfkqaqvtg seennqnppy ydfsgsrisq mynavlylak 601 yddefdirdr armisslfds gkyeivslll qapkptarsd dfivsarlet htpeikeffr 661 mlpwnteite vgetgndire gaelkdynky kksfssqsfi tnnsarsfts ssnakltgin 721 dgdsnsisgk gnvntftsqn gkkyrlqsld effsdiperk skprkiikvv eessdedede 781 seessdddey sdsslgtsss gtssshlel // LOCUS NP_011778 261 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase BUD32 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011778 VERSION NP_011778.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181391.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08352. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..261 /product="serine/threonine protein kinase BUD32" /EC_number="2.7.11.1" /calculated_mol_wt="29805" Region 21..255 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" CDS 1..261 /gene="BUD32" /locus_tag="YGR262C" /gene_synonym="LDB14" /coded_by="NM_001181391.1:1..786" /experiment="EXISTENCE:direct assay:GO:0000408 EKC/KEOPS complex [PMID:16874308|PMID:16564010]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:9305753|PMID:14519092]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14519092|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:36416748]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:16564010]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:11452010]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:36416748|PMID:16564010]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:14519092]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:36416748]" /experiment="EXISTENCE:mutant phenotype:GO:0070525 tRNA threonylcarbamoyladenosine metabolic process [PMID:21183954]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16874308]" /note="Component of KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; provides the ATPase and GTPase activities of the complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; mutation is functionally complemented by human ortholog TP53RK" /db_xref="GeneID:853178" /db_xref="SGD:S000003494" ORIGIN 1 mtqefidkvs syltpdvdia pisqgaeaiv ftttthpylp rakdshqkyi ikyrppkryr 61 hpqidqaltk hrtlnesrll aklylipglc vpqliacdpy ngfiwleflg edlpgghgfs 121 nlknflwmhd qdpysdlvat tlrkvgrqig llhwndychg dltssnivlv rdgarwtphl 181 idfglgsvsn lvedkgvdly vlerailsth skhaekynaw imegfeevyr eqgakgakkl 241 kevtkrfeev rlrgrkrsml g // LOCUS NP_011779 424 aa linear PLN 30-JUN-2025 DEFINITION steryl deacetylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011779 VERSION NP_011779.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181392.3 REFERENCE 1 (residues 1 to 424) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 424) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 424) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 424) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08353. On Jul 30, 2012 this sequence version replaced NP_011779.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..424 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..424 /product="steryl deacetylase" /calculated_mol_wt="48410" Region 50..421 /region_name="Say1_Mug180" /note="Steryl acetyl hydrolase; pfam10340" /db_xref="CDD:313549" CDS 1..424 /gene="SAY1" /locus_tag="YGR263C" /coded_by="NM_001181392.3:1..1275" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762|PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:18034159]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:18034159]" /experiment="EXISTENCE:direct assay:GO:0034084 steryl deacetylase activity [PMID:18034159]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0009636 response to toxic substance [PMID:18034159]" /experiment="EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:18034159]" /experiment="EXISTENCE:mutant phenotype:GO:0034084 steryl deacetylase activity [PMID:18034159]" /note="Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; active both in the endoplasmic reticulum (ER) and in lipid droplets; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the ER" /db_xref="GeneID:853179" /db_xref="SGD:S000003495" ORIGIN 1 maansgldsk veyyrlqene iisavsseda dqndagfrls tihlhlfhgl kfaallftvv 61 pvfiildsmk iifqrkrrfc ldhvnrsflr qsswilderi cqyvlnplfv clypstfssp 121 tyvkcnipie dqkspennif qdhqlnapki vstkfyqyvm pegfdpttdp vlvfyhgggy 181 alkltptsfs flnnmrnafp kmailvpdyt vtatddqskk yplqilqnva ifdyvvktmg 241 cknvvimgds aggnavlniv lylrkchrei ypkkviaisp wanatffheg ekeymqgtqe 301 wdglclkshs mfgrmfvgnn pnvdftsdpf vnieknfetk mwqdilkkcs vmitygsdel 361 lsfqnkilak kmsdasegcn hftaknvlve hqgyhtgpil nysrnmdrwt nipsiarile 421 fmqs // LOCUS NP_011780 751 aa linear PLN 30-JUN-2025 DEFINITION methionine--tRNA ligase MES1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011780 VERSION NP_011780.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181393.3 REFERENCE 1 (residues 1 to 751) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 751) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 751) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 751) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08354. On Jul 30, 2012 this sequence version replaced NP_011780.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..751 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..751 /product="methionine--tRNA ligase MES1" /EC_number="6.1.1.10" /calculated_mol_wt="85547" Region 11..132 /region_name="MetRS-N" /note="MetRS-N binding domain; pfam09635" /db_xref="CDD:401537" Region 190..>750 /region_name="PLN02610" /note="probable methionyl-tRNA synthetase" /db_xref="CDD:215329" CDS 1..751 /gene="MES1" /locus_tag="YGR264C" /coded_by="NM_001181393.3:1..2256" /experiment="EXISTENCE:direct assay:GO:0004825 methionine-tRNA ligase activity [PMID:3312199]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:3905796]" /experiment="EXISTENCE:direct assay:GO:0006431 methionyl-tRNA aminoacylation [PMID:3312199]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26359986]" /experiment="EXISTENCE:direct assay:GO:0017102 methionyl glutamyl tRNA synthetase complex [PMID:11069915]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Methionyl-tRNA synthetase; forms a complex with Gus1p, a glutamyl-tRNA synthetase, and Arc1p, which increases the catalytic efficiency of both synthetases; involved in the nuclear export of tRNAs; mutations in human ortholog MARS is associated with pediatric pulmonary alveolar proteinosis, interstitial lung and liver disease, and Charcot-Marie-Tooth disease; human MARS gene can complement the yeast null mutant" /db_xref="GeneID:853181" /db_xref="SGD:S000003496" ORIGIN 1 msflisfdks kkhpahlqla nnlkialale yasknlkpev dndnaamelr ntkepfllfd 61 anailryvmd dfegqtsdky qfalaslqnl lyhkelpqqh vevltnkaie nylvelkepl 121 tttdlilfan vyalnsslvh skfpelpskv hnavalakkh vprdsssfkn igavkiqadl 181 tvkpkdseil pkpnernili tsalpyvnnv phlgniigsv lsadifaryc kgrnynalfi 241 cgtdeygtat etkaleegvt prqlcdkyhk ihsdvykwfq igfdyfgrtt tdkqteiaqh 301 iftklnsngy leeqsmkqly cpvhnsylad ryvegecpkc hyddargdqc dkcgalldpf 361 elinprckld daspepkysd hiflsldkle sqisewveka seegnwskns ktitqswlkd 421 glkprcitrd lvwgtpvple kykdkvlyvw fdatigyvsi tsnytkewkq wwnnpehvsl 481 yqfmgkdnvp fhtvvfpgsq lgteenwtml hhlntteylq yengkfsksr gvgvfgnnaq 541 dsgispsvwr yylasvrpes sdshfswddf varnnsella nlgnfvnrli kfvnakyngv 601 vpkfdpkkvs nydglvkdin eilsnyvkem elgherrgle iamslsargn qflqenkldn 661 tlfsqspeks davvavglni iyavssiitp ympeigekin kmlnapalki ddrfhlaile 721 ghninkaeyl fqridekkid ewrakyggqq v // LOCUS NP_011782 701 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR266W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011782 VERSION NP_011782.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181395.1 REFERENCE 1 (residues 1 to 701) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 701) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 701) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 701) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08355. Method: conceptual translation. FEATURES Location/Qualifiers source 1..701 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..701 /product="uncharacterized protein" /calculated_mol_wt="81060" Region 110..599 /region_name="PhoD_2" /note="PhoD related phosphatase; pfam19050" /db_xref="CDD:408820" CDS 1..701 /locus_tag="YGR266W" /coded_by="NM_001181395.1:1..2106" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340]" /note="hypothetical protein; predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853182" /db_xref="SGD:S000003498" ORIGIN 1 mhatnwfddw npealyrddv tgcddcsets pipksgiicg pilrlinmdf kektyegsim 61 vvvrgeenfp kityqlgpsl psededievn eaffegklfh kdilkddniw fyryeiklpm 121 snyeqmvkya vdgtmephyr ffvpsftqns nvisyscngf slsvdtskfk gslwydvlkk 181 hryvhyhail gggdqiysdn iklhapnlka wletkdpikk yntqtteetk eqirqfyleh 241 ylnwygyghw ygstpksktt qkcfvkslac ipainvwddh diidgygsyn dsfmktenfl 301 tvgrmayryy mlfqqhvsas kqdgdeyayl kskqwilgne kgssyigers hsifswlgpk 361 mamlgldcrt erklheifse rsysliwerv ereiknlkgg hlllmlgipi ayprlvwlew 421 lftskllapi kylskkgifa sgfvnefngd vellddlndh wcarhhkker nylimklqdi 481 gakygvriti lsgdvhlasv grfrakihrh hlimseekek entriieept kdvrlifnii 541 asaivntppp damatllqkr crlhhfdlet dedavpifak evdgvhkrke scfmnkrnws 601 diipienlln npqlskelgv kvgdivipgi iteqqklqkl enddqinsyp vtsgglftti 661 hverdanqtn sqtvsyclpi peltvtcerl shkgikhlni t // LOCUS NP_011783 243 aa linear PLN 30-JUN-2025 DEFINITION GTP cyclohydrolase I [Saccharomyces cerevisiae S288C]. ACCESSION NP_011783 VERSION NP_011783.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181396.1 REFERENCE 1 (residues 1 to 243) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 243) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 243) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 243) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08356. Method: conceptual translation. FEATURES Location/Qualifiers source 1..243 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..243 /product="GTP cyclohydrolase I" /EC_number="3.5.4.16" /calculated_mol_wt="27638" Site order(57,60..61,64,68,71..72,74,76,78,80..82,84..85,87,91, 94,99,111,113,117..120,122..125,127,129,133..134,137..138, 140,142,149..150,152,156..158,161,171..173,175,178,188, 201..203,206..207,212..213,215..217,219..221,226..227,229, 231..233) /site_type="other" /note="homodecamer interface [polypeptide binding]" /db_xref="CDD:238349" Region 61..240 /region_name="folE" /note="GTP cyclohydrolase I; TIGR00063" /db_xref="CDD:129173" Site order(87,90,132,134..135,154,156..157,161,172..174,201,203, 207) /site_type="active" /db_xref="CDD:238349" Site order(132,134..135,201,203) /site_type="active" /note="putative catalytic site residues [active]" /db_xref="CDD:238349" Site order(132,134..135,203) /site_type="other" /note="zinc binding site [ion binding]" /db_xref="CDD:238349" Site order(182,185,191,193,222..224,226..227,228..229) /site_type="active" /note="GTP-CH-I/GFRP interaction surface [active]" /db_xref="CDD:238349" CDS 1..243 /gene="FOL2" /locus_tag="YGR267C" /coded_by="NM_001181396.1:1..732" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:31323700|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0003934 GTP cyclohydrolase I activity [PMID:8573145]" /experiment="EXISTENCE:mutant phenotype:GO:0009396 folic acid-containing compound biosynthetic process [PMID:8573145]" /note="GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant" /db_xref="GeneID:853183" /db_xref="SGD:S000003499" ORIGIN 1 mhniqlvqei erhetplnir ptspytlnpp verdgfswps vgtrqraeet eeeekeriqr 61 isgaiktilt elgedvnreg lldtpqryak amlyftkgyq tnimddvikn avfeedhdem 121 vivrdieiys lcehhlvpff gkvhigyipn kkviglskla rlaemyarrl qvqerltkqi 181 amalsdilkp lgvavvmeas hmcmvsrgiq ktgsstvtsc mlggfrahkt reefltllgr 241 rsi // LOCUS NP_011784 198 aa linear PLN 30-JUN-2025 DEFINITION Hua1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011784 VERSION NP_011784.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181397.3 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08357. On Jul 30, 2012 this sequence version replaced NP_011784.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..198 /product="Hua1p" /calculated_mol_wt="22304" Region <162..>195 /region_name="PRK14277" /note="chaperone protein DnaJ; Provisional" /db_xref="CDD:184599" CDS 1..198 /gene="HUA1" /locus_tag="YGR268C" /coded_by="NM_001181397.3:1..597" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11489916|PMID:11914276]" /note="Cytoplasmic protein containing a zinc finger domain; sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly" /db_xref="GeneID:853185" /db_xref="SGD:S000003500" ORIGIN 1 mskdthddel psyedvikee erlqsqpprp prpaanlaqg hqsrphqrps tmpatsssqt 61 yahshsytpt ssqprppprp qqnpslpwty pprfycskcg ntgyklkngr sckscwrrfa 121 pqnnvvsapt yytnytmpvy tnawqgnrpl yvqpgdprlg gvlcgecrgs grtrfllded 181 icplchgvgr iitqpqry // LOCUS NP_011786 1379 aa linear PLN 30-JUN-2025 DEFINITION chromatin segregase YTA7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011786 VERSION NP_011786.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181399.1 REFERENCE 1 (residues 1 to 1379) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1379) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1379) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1379) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08358. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1379 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1379 /product="chromatin segregase YTA7" /calculated_mol_wt="157276" Region 414..583 /region_name="RecA-like_Yta7-like" /note="ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; cd19517" /db_xref="CDD:410925" Site order(459..462,465,518,562) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:410925" Region 611..649 /region_name="AAA_lid_3" /note="AAA+ lid domain; pfam17862" /db_xref="CDD:465537" Region 772..>839 /region_name="AAA" /note="ATPase family associated with various cellular activities (AAA); pfam00004" /db_xref="CDD:459627" Region 979..1098 /region_name="Bromo_TBP7_like" /note="Bromodomain; TBP7_like subfamily, limited to fungi. TBP7, or TAT-binding protein homolog 7, is a yeast protein of unknown function that contains AAA-superfamily ATP-ase domains and a bromodomain. Bromodomains are found in many chromatin-associated...; cd05491" /db_xref="CDD:99923" Site order(1029,1033,1036,1075,1079,1083) /site_type="other" /note="putative acetyllysine binding site [chemical binding]" /db_xref="CDD:99923" CDS 1..1379 /gene="YTA7" /locus_tag="YGR270W" /coded_by="NM_001181399.1:1..4140" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:34471130]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:19581291|PMID:18493054]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095|PMID:26928762|PMID:22842922|P MID:19416104]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:34471130]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:34471130]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:16079223|PMID:19581291]" /experiment="EXISTENCE:direct assay:GO:0140658 ATP-dependent chromatin remodeler activity [PMID:34471130]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18493054]" /experiment="EXISTENCE:mutant phenotype:GO:0003682 chromatin binding [PMID:19581291]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:34471130]" /experiment="EXISTENCE:mutant phenotype:GO:0006337 nucleosome disassembly [PMID:34471130]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:32079723]" /experiment="EXISTENCE:mutant phenotype:GO:0042393 histone binding [PMID:19581291]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:19683497]" /experiment="EXISTENCE:mutant phenotype:GO:0140658 ATP-dependent chromatin remodeler activity [PMID:34471130]" /experiment="EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:18202364]" /note="Chromatin segregase involved in DNA replication; ATPase activity, stimulated by S phase CDK-dependent phosphorylation, is coupled to nucleosome disassembly, promoting DNA replication; regulates cell-cycle-dependent histone gene expression; contains AAA+-ATPase domains and a non-canonical bromodomain; hexameric; relocalizes to the cytosol in response to hypoxia; human ortholog ATAD2 is a coregulator of oncogenic transcription factors and an oncogene overexpressed in cancers with poor prognosis" /db_xref="GeneID:853186" /db_xref="SGD:S000003502" ORIGIN 1 marnlrnrrg sdvedasnak vgyetqikde ngiihtttrs lrkinyaeie kvfdfleddq 61 vmdkdetpvd vtsdehhnnn qkgddedddv dlvsphenar tneeltnern lrkrkahdpe 121 eddesfheed vdddeeeeea defedeylde dskdnnrrrr aadrkfvvpd pdddeeyded 181 deegdrishs asskrlkran srrtrssrhp etpppvrral rsrtrhsrts neenddendn 241 srnealtlad eirelqedsp irekrflrer tkpvnyklpp pltasnaeef idknnnalsf 301 hnpsparrgr ggwnasqnsg ptrrlfptgg pfggndvtti fgkntnfynq vpsafsdnnn 361 nklildsdss ddeilplgvt pktkkentqk kkkkkpeiad ldplgvdmnv nfddiggldn 421 yidqlkemva lpllypelyq nfnitpprgv lfhgppgtgk tlmaralaas cssderkitf 481 fmrkgadils kwvgeaerql rllfeeakkh qpsiiffdei dglapvrssk qeqihasivs 541 tllalmdgmd nrgqviviga tnrpdavdpa lrrpgrfdre fyfplpdvka rfkilqiqtr 601 kwssplstnf idklafltkg yggadlrslc teaalisiqr sfpqiyrsnd kllvdpskik 661 vkvsdfmlal kkivpssars tgsspqplpe likplladql nnlknkldym lnikdttfqr 721 ntsllqnfid yeeysgeeee hdkyggnedt ssfrsyeffe smaesqickp rllingpkgn 781 gqqyvgaail nyleefnvqn ldlaslvses srtieaavvq sfmeakkrqp svvfipnldi 841 wintipenvi lvlsglfrsl qsnekilllc laenldisev kngilsdfaf dknifqlhkp 901 skenitryfs nliellktkp sdipmkkrrv kplpelqkvt snaaptnfde ngeplsekvv 961 lrrklksfqh qdmrlknvlk iklsglmdlf knrykrfrkp piddaflvhl fepetsndpn 1021 wqpayikden milevstgrk ffnmdldive erlwngyyse pkqflkdiel iyrdantigd 1081 rervikasem fanaqmgiee istpdfiqec katrqrdler qelfledeek raameleake 1141 qsqenilqep dlkdnkanef gvaagnqlqa qlqttintas ivnnsevpqp idtnlykkei 1201 paaipsavdk ekavipedsg aneeytteli qatctseitt ddderarkep kenedslqtq 1261 vteenfskid antnninhvk eiqsvnkpns lhetvekrer spipkevvep eqgkksdkel 1321 iltpeqikkv sacliehcqn ftvsqledvh ssvakiiwks ksawdktgtv deiikflse // LOCUS NP_011787 1967 aa linear PLN 30-JUN-2025 DEFINITION RNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011787 VERSION NP_011787.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181400.4 REFERENCE 1 (residues 1 to 1967) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1967) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1967) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1967) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1967) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1967) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1967) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1967) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08359. On Jul 30, 2012 this sequence version replaced NP_011787.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1967 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1967 /product="RNA helicase" /EC_number="3.6.4.13" /calculated_mol_wt="224720" Region 283..832 /region_name="BRR2" /note="Replicative superfamily II helicase [Replication, recombination and repair]; COG1204" /db_xref="CDD:440817" Region 287..489 /region_name="DEXHc_ASCC3_1" /note="N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; cd18020" /db_xref="CDD:350778" Site order(287..289,292,312..318) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350778" Site order(355..356,383,400,402..403,406,436) /site_type="other" /note="nucleic acid binding site [nucleotide binding]" /db_xref="CDD:350778" Region 795..1099 /region_name="Sec63" /note="Sec63 Brl domain; pfam02889" /db_xref="CDD:460740" Region 1136..1655 /region_name="BRR2" /note="Replicative superfamily II helicase [Replication, recombination and repair]; COG1204" /db_xref="CDD:440817" Region 1139..1327 /region_name="DEXHc_ASCC3_2" /note="C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; cd18022" /db_xref="CDD:350780" Site order(1139..1141,1144,1164..1170) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350780" Region 1623..1967 /region_name="SEC63" /note="Domain of unknown function in Sec63p, Brr2p and other proteins; smart00611" /db_xref="CDD:214744" CDS 1..1967 /gene="SLH1" /locus_tag="YGR271W" /gene_synonym="RQT2" /coded_by="NM_001181400.4:1..5904" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0072344 rescue of stalled ribosome [PMID:30893611|PMID:31189955|PMID:27385828|PMID:27129255|P MID:25554787]" /experiment="EXISTENCE:direct assay:GO:0140708 CAT tailing [PMID:31133701]" /experiment="EXISTENCE:direct assay:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:27385828|PMID:27129255]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:21076151]" /experiment="EXISTENCE:mutant phenotype:GO:0006417 regulation of translation [PMID:11438647|PMID:10922069]" /note="Subunit of ribosome-associated quality control trigger complex (RQT); contains ATPase activity required for subunit dissociation of non-functional 80S ribosomes containing polyubiquitinated Rps3p, leading to Xrn1-dependent degradation of the non-functional 18S rRNA; blocks translation of non-poly(A) mRNAs; required to repress the propagation of dsRNA viruses; RNA helicase-family protein related to Ski2p; human homolog is ASCC3" /db_xref="GeneID:853187" /db_xref="SGD:S000003503" ORIGIN 1 msteysadss ksfmiamqsm idtsqtfnld rskislpdfd delkkvqkde qnqrteltvl 61 sqdrndwddi feefkdisfa qlqsiidsyk tknavavykk igklineaet tlssnvllet 121 vlqmvykhqk qelekelldf lgtgnidlvs lllqhrrmiv atpiettill iknavnstpe 181 fltqqdirnq vlksaedakn rklnpatkii kyphvfrkye agsttamafa gqkftlpvgt 241 trmsynthee iiipaadqas nknylytkll kisdldhfck tvfpyetlnq iqslvypvay 301 ktnenmlica ptgagktdia lltiintikq fsvvngenei diqyddfkvi yvaplkalaa 361 eivdkfskkl apfniqvrel tgdmqltkae ilatqvivtt pekwdvvtrk angdndlvsk 421 vklliidevh llhedrgsvi etlvartlrq vessqsmiri iglsatlpnf mdvadflgvn 481 rqigmfyfdq sfrpkpleqq llgcrgkags rqskenidkv aydklsemiq rgyqvmvfvh 541 srketvksar nfiklaesnh evdlfapdpi ekdkysrslv knrdkdmkei fqfgfgihha 601 gmarsdrnlt ekmfkdgaik vlcctatlaw gvnlpadcvi ikgtqvydsk kggfidlgis 661 dviqifgrgg rpgfgsangt gilctsndrl dhyvslitqq hpiesrfgsk lvdnlnaeis 721 lgsvtnvdea iewlgytymf vrmrknpfty gidweeiand pqlyerrrkm ivvaarrlha 781 lqmivfdevs mhfiakdlgr vssdfyllne sveifnqmcd prateadvls mismssefdg 841 ikfreeeske lkrlsdesve cqigsqldtp qgkanvllqa yisqtrifds alssdsnyva 901 qnsvricral fligvnrrwg kfsnvmlnic ksiekrlwaf dhplcqfdlp eniirrirdt 961 kpsmehllel eadelgelvh nkkagsrlyk ilsrfpkini eaeifpittn vmrihialgp 1021 dfvwdsrihg daqffwvfve esdksqilhf ekfilnrrql nnqhemdfmi plsdplppqv 1081 vvkvvsdtwi gcesthaisf qhlirpfnet lqtkllklrp lptsalqnpl iesiypfkyf 1141 npmqtmtfyt lyntnenafv gsptgsgkti vaelaiwhaf ktfpgkkivy iapmkalvre 1201 rvddwrkkit pvtgdkvvel tgdslpdpkd vhdativitt pekfdgisrn wqtrkfvqdv 1261 sliimdeihl lasdrgpile mivsrmnyis sqtkqpvrll gmstavsnay dmagwlgvkd 1321 hglynfpssv rpvplkmyid gfpdnlafcp lmktmnkpvf maikqhspdk palifvasrr 1381 qtrltaldli hlcgmednpr rflniddeee lqyylsqvtd dtlklslqfg iglhhaglvq 1441 kdrsishqlf qknkiqilia tstlawgvnl pahlviikgt qffdakiegy rdmdltdilq 1501 mmgragrpay dttgtaivyt keskkmfykh flnvgfpves slhkvlddhl gaeitsgsit 1561 nkqealdfls wtflfrrahh nptyygiedd tstagvsehl sslidstlen lresqcvllh 1621 gddivatpfl sissyyyish ltirqllkqi hdhatfqevl rwlslaveyn elpvrggeii 1681 mneemsqqsr ysvestftde felpmwdphv ktflllqahl srvdlpiady iqdtvsvldq 1741 slrilqayid vaselgyfht vltmikmmqc ikqgywyedd pvsvlpglql rrikdytfse 1801 qgfiemtpqq kkkklltlee igrfgykkll nvfdqltfgm tesedtkkrf vsvcqrlpvl 1861 egmkfeeqen nevltfyskh lsskhnngfe vycdkfpkiq kelwflighk gdellmikrc 1921 qpkqmnkevi ihcdlfipee irgeelqfsl indalglryd mvhklis // LOCUS NP_076891 233 aa linear PLN 30-JUN-2025 DEFINITION Efg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_076891 VERSION NP_076891.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184474.3 REFERENCE 1 (residues 1 to 233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 233) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08360. On Jul 30, 2012 this sequence version replaced NP_076891.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..233 /product="Efg1p" /calculated_mol_wt="26990" Region 29..141 /region_name="Efg1" /note="rRNA-processing protein Efg1; pfam10153" /db_xref="CDD:462968" CDS 1..233 /gene="EFG1" /locus_tag="YGR271C-A" /gene_synonym="YGR272C" /coded_by="NM_001184474.3:1..702" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:16510898]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12837249]" /experiment="EXISTENCE:mutant phenotype:GO:0071027 nuclear RNA surveillance [PMID:29481617]" /note="Ribosome biogenesis factor required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus" /db_xref="GeneID:853188" /db_xref="SGD:S000007608" ORIGIN 1 maklqrkrsk algsslemsq imdagtnkik rrirdlerll kkkkdilpst viiekernlq 61 alrlelqnne lknkikanak kyhmvrffek kkalrkynrl lkkikesgad dkdlqqklra 121 tkielcyvin fpktekyial ypndtpstdp kgveltnlrr eqflklvaer mdantlnvsf 181 eeilkgkkld edsigltlsp dkdhedgsqv sptqdrkeld qvvgedekdd ffe // LOCUS NP_011789 174 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YGR273C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011789 VERSION NP_011789.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181402.1 REFERENCE 1 (residues 1 to 174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 174) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08361. Method: conceptual translation. FEATURES Location/Qualifiers source 1..174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..174 /product="uncharacterized protein" /calculated_mol_wt="19883" Region 33..110 /region_name="DUF2406" /note="Uncharacterized protein (DUF2406); pfam10295" /db_xref="CDD:402077" CDS 1..174 /locus_tag="YGR273C" /coded_by="NM_001181402.1:1..525" /note="hypothetical protein; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; not an essential gene; YGR273C has a paralog, YMR295C, that arose from the whole genome duplication" /db_xref="GeneID:853190" /db_xref="SGD:S000003505" ORIGIN 1 mqhfessdki ekdddtsrik lrssslaapi leavqeaqpf eeatfsnlqk ihpltenstc 61 ngyviydkdg nlksmkdtfg rniktpdisn ptrarnerpl dtirgfeysi tkdprwlqel 121 etsklgfkpr pgfavinqds qasinlsqle ekvmesqkkk ekrhisrlsr llcr // LOCUS NP_011790 1066 aa linear PLN 30-JUN-2025 DEFINITION histone acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011790 VERSION NP_011790.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181403.2 REFERENCE 1 (residues 1 to 1066) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1066) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1066) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1066) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08362. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1066 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1066 /product="histone acetyltransferase" /EC_number="2.3.1.48" /calculated_mol_wt="120565" Region 21..1066 /region_name="TAF1" /note="Transcription initiation factor TFIID, subunit TAF1 [Transcription]; COG5179" /db_xref="CDD:227506" CDS 1..1066 /gene="TAF1" /locus_tag="YGR274C" /gene_synonym="KAT4; TAF130; TAF145" /coded_by="NM_001181403.2:1..3201" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10818000|PMID:12600943|PMID:10817999]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:8980232]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:11677244]" /experiment="EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:15143185]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:9288742|PMID:9288741]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001|PMID:10713163|PMID:12600943]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:15143185|PMID:9844639]" /note="TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:853191" /db_xref="SGD:S000003506" ORIGIN 1 mvkqqgsgkt nlanedeaye aifggefgsl eigsyiggde ganskdyteh lpdavdfede 61 deladddddl peesdanlhp ammtmgaydd vnengavlgi dsnslnmqlp eingdlsqqf 121 ileddggtpa tsnalfmgmd aneihlatet gvldgsgane ighsqlsigg vngndmsing 181 gfimepdmsd gkhkkatkld linhekyllk kyfpdfekgk ilkwnkliyr rsvpyhwhse 241 isrvkkpfmp lnlkfkvqqd dkrlfnsrti syvapiyqgk nnllqsnssa srrglihvsi 301 delfpikeqq kkrkiihdek tisedlliat ddwdqekiin qgtsstatla dssmtpnlkf 361 sggyklksli edvaedwqwd edmiidaklk eskhaelnmn deklllmiek tnnlaqqkqq 421 ldssnlilpl netilqqkfn lsnddkyqil kkthqtkvrs tisnlniqhs qpainlqspf 481 ykvavpryql rhfhrenfgs hirpgtkivf sklkarkrkr dkgkdvkesf stsqdltigd 541 tapvylmeys eqtpvalskf gmanklinyy rkaneqdtlr pklpvgethv lgvqdkspfw 601 nfgfvepghi vptlynnmir apvfkhdisg tdflltkssg fgisnrfylr ninhlftvgq 661 tfpveeipgp nsrkvtsmka trlkmiiyri lnhnhskais idpiakhfpd qdygqnrqkv 721 kefmkyqrdg pekglwrlkd deklldneav kslitpeqis qvesmsqglq fqedneaynf 781 dsklksleen llpwnitknf instqmrami qihgvgdptg cgegfsflkt smkggfvksg 841 spssnnnssn kkgtnthsyn vaqqqkayde eiaktwytht kslsisnpfe emtnpdeinq 901 tnkhvktdrd dkkilkivrk krdengiiqr qtifirdprv iqgyikikeq dkedvnklle 961 edtskinnle elekqkkllq lelanleksq qrraarqnsk rnggatrten svdngsdlag 1021 vtdgkaarnk gknttrrcat cgqighirtn kscpmysskd npaspk // LOCUS NP_011791 157 aa linear PLN 30-JUN-2025 DEFINITION Rtt102p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011791 VERSION NP_011791.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181404.3 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08363. On Jul 30, 2012 this sequence version replaced NP_011791.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..157 /product="Rtt102p" /calculated_mol_wt="17664" Region 5..140 /region_name="Rtt102p" /note="Rtt102p-like transcription regulator protein; pfam09510" /db_xref="CDD:430654" CDS 1..157 /gene="RTT102" /locus_tag="YGR275W" /coded_by="NM_001181404.3:1..474" /experiment="EXISTENCE:curator inference:GO:0006338 chromatin remodeling [PMID:14729968]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:17188033]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0015616 DNA translocase activity [PMID:17188033]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:15506919|PMID:18644858]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:14729968]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:14729968]" /note="Component of both the SWI/SNF and RSC chromatin remodeling complexes; suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853192" /db_xref="SGD:S000003507" ORIGIN 1 mdpqtlitka nkvsyygnpt skeswrydwy qpskvssnvq qpqqqlgdme nnlekypfry 61 ktwlrnqede knlqresced ildlkefdrr ilkkslmtsh tkgdtskatg apsanqgdea 121 lsvddirgav gnseaipgls agvnndntke skdvkmn // LOCUS NP_011792 553 aa linear PLN 30-JUN-2025 DEFINITION Rnh70p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011792 VERSION NP_011792.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181405.1 REFERENCE 1 (residues 1 to 553) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 553) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 553) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 553) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08364. Method: conceptual translation. FEATURES Location/Qualifiers source 1..553 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..553 /product="Rnh70p" /calculated_mol_wt="62718" Region 226..374 /region_name="REX1_like" /note="DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; cd06145" /db_xref="CDD:99848" Site order(229..232,234,308..309,311..313,360,365) /site_type="active" /db_xref="CDD:99848" Site order(229..232,234,308..309,311..312,360,365) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:99848" Site order(229,231,313,360,365) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:99848" CDS 1..553 /gene="RNH70" /locus_tag="YGR276C" /gene_synonym="REX1; RNA82" /coded_by="NM_001181405.1:1..1662" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10359084]" /experiment="EXISTENCE:genetic interaction:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10716935]" /experiment="EXISTENCE:genetic interaction:GO:0034476 U5 snRNA 3'-end processing [PMID:10716935]" /experiment="EXISTENCE:genetic interaction:GO:0042780 tRNA 3'-end processing [PMID:18456844]" /experiment="EXISTENCE:mutant phenotype:GO:0000175 3'-5'-RNA exonuclease activity [PMID:10716935]" /experiment="EXISTENCE:mutant phenotype:GO:0002107 generation of mature 3'-end of 5S rRNA generated by RNA polymerase III [PMID:10716935]" /experiment="EXISTENCE:mutant phenotype:GO:0042780 tRNA 3'-end processing [PMID:18456844|PMID:10716935]" /note="3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts" /db_xref="GeneID:853193" /db_xref="SGD:S000003508" ORIGIN 1 mqvegpdtnf vsdlalgskk rrlsktsvqe ddhtnvvsev nknkkkkkak pmtctllksv 61 vekgigikdv rdmtqyllqa ennspkwidi cnrsslqkmi vlfipglqpd dfengkntfn 121 eisddnfkyi pgeiastfht fpvmapgskm tlfspynsfi nvglskmeki nklkelqkkk 181 kitindlvls eqqlvandyp ldsgdtnfdt dwvqtvdfth ggshifaldc emclseqglv 241 ltrislvnfd neviyeelvk pdvpivdylt rysgiteekl tvgakktlre vqkdllkiis 301 rsdilighsl qndlkvmklk hplvvdtaii yhhkagdpfk pslkylsetf lnksiqngeh 361 dsvedaracl eltklkilng lafgiginte nlftklhrfe vktvllndmi iknhteddsk 421 gqlircvedd etwthihenl nkdvklivgr iknlersrny nkkprketps fdasmvlhdi 481 gqhltqlyen atpgtmilim sgtgdtrpwn nlstelefiq dkkerldkrr erepeiveai 541 klarggvasf tvk // LOCUS NP_011793 305 aa linear PLN 30-JUN-2025 DEFINITION putative pantetheine-phosphate adenylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011793 VERSION NP_011793.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181406.3 REFERENCE 1 (residues 1 to 305) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 305) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 305) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 305) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08365. On Jul 30, 2012 this sequence version replaced NP_011793.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..305 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..305 /product="putative pantetheine-phosphate adenylyltransferase" /EC_number="2.7.7.3" /calculated_mol_wt="34176" Region 144..288 /region_name="PPAT_CoAS" /note="phosphopantetheine adenylyltransferase domain of eukaryotic and archaeal bifunctional enzymes; cd02164" /db_xref="CDD:173915" Site order(149..150,178,238) /site_type="active" /db_xref="CDD:173915" Site 155..158 /site_type="other" /note="(T/H)XGH motif" /db_xref="CDD:173915" CDS 1..305 /gene="CAB4" /locus_tag="YGR277C" /coded_by="NM_001181406.3:1..918" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:1990143 CoA-synthesizing protein complex [PMID:23789928]" /experiment="EXISTENCE:genetic interaction:GO:0015937 coenzyme A biosynthetic process [PMID:19266201]" /note="Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; involved in histone acylation; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT) and by human COASY" /db_xref="GeneID:853194" /db_xref="SGD:S000003509" ORIGIN 1 mveensrvli vlpytppsat lqriigqtip flrecqsqld ivivpefkts fqldsalgkm 61 ysitrdvllg ygminsgini ifnnihfves nlqwkvvllp qestfetwkl elgqgqyhsi 121 ehyalhdnim eeiegpkdan kfhvtalggt fdhihdghki llsvstfits qrlicgitcd 181 ellqnkkyke liepydtrcr hvhqfikllk pdlsvelvpl rdvcgptgkv peieclvvsr 241 etvsgaetvn ktriekgmsp lavhvvnvlg greedgwsek lssteirrll kssasptctp 301 qnpcv // LOCUS NP_011794 577 aa linear PLN 30-JUN-2025 DEFINITION U2-type spliceosomal complex subunit CWC22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011794 VERSION NP_011794.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181407.3 REFERENCE 1 (residues 1 to 577) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 577) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 577) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 577) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08366. On Jul 30, 2012 this sequence version replaced NP_011794.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..577 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..577 /product="U2-type spliceosomal complex subunit CWC22" /calculated_mol_wt="67163" Region 24..204 /region_name="MIF4G" /note="Middle domain of eukaryotic initiation factor 4G (eIF4G); smart00543" /db_xref="CDD:214713" Region 291..398 /region_name="MA3" /note="MA3 domain; pfam02847" /db_xref="CDD:397128" CDS 1..577 /gene="CWC22" /locus_tag="YGR278W" /coded_by="NM_001181407.3:1..1734" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:20956557]" /experiment="EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]" /note="Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein" /db_xref="GeneID:853195" /db_xref="SGD:S000003510" ORIGIN 1 mstatiqded ikfqrenwem irshvspiis nltmdnlqes hrdlfqvnil igrniicknv 61 vdftlnkqng rlipalsali allnsdipdi getlakelml mfvqqfnrkd yvscgnilqc 121 lsilflydvi heivilqill llleknslrl viavmkicgw klalvskkth dmiweklryi 181 lqtqelsstl resletlfei rqkdyksgsq glfildptsy tvhthsyivs dedeankelg 241 nfekcenfne ltmafdtlrq kllinntsdt negsnsqlqi ydmtstndve fkkkiylvlk 301 sslsgdeaah kllklkiann lkksvvdiii ksslqestfs kfysilserm itfhrswqta 361 ynetfeqnyt qdiedyetdq lrilgkfwgh lisyeflpmd clkiikltee escpqgrifi 421 kflfqelvne lgldelqlrl nsskldgmfp legdaehiry sinfftaigl glltedmrsr 481 ltiiqeveda eeeekklree eeleklrkka resqptqgpk ihesrlflqk dtrensrsrs 541 pftvetrkra rsrtpprgsr nhrnrsrtpp arrqrhr // LOCUS NP_011795 386 aa linear PLN 30-JUN-2025 DEFINITION putative family 17 glucosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011795 VERSION NP_011795.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181408.1 REFERENCE 1 (residues 1 to 386) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 386) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 386) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 386) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08367. Method: conceptual translation. FEATURES Location/Qualifiers source 1..386 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..386 /product="putative family 17 glucosidase" /calculated_mol_wt="40042" Region 125..>383 /region_name="Scw11" /note="Exo-beta-1,3-glucanase, GH17 family [Carbohydrate transport and metabolism]; COG5309" /db_xref="CDD:444107" CDS 1..386 /gene="SCW4" /locus_tag="YGR279C" /coded_by="NM_001181408.1:1..1161" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:19129178]" /experiment="EXISTENCE:direct assay:GO:0005773 vacuole [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9748433|PMID:15781460]" /experiment="EXISTENCE:genetic interaction:GO:0000747 conjugation with cellular fusion [PMID:9748433]" /note="Cell wall protein with similarity to glucanases; targeted to vacuole via AP-3 pathway; scw4 scw10 double mutants exhibit defects in mating; SCW4 has a paralog, SCW10, that arose from the whole genome duplication" /db_xref="GeneID:853196" /db_xref="SGD:S000003511" ORIGIN 1 mrlsnliasa sllsaatlaa panhehkdkr avvtttvqkq ttiivngaas tpvaaleena 61 vvnsapaaat sttssaasva taaasssenn sqvsaaaspa sssaatstqs ssssqassss 121 ssgedvssfa sgvrgitytp yessgacksa sevasdlaql tdfpvirlyg tdcnqvenvf 181 kakasnqkvf lgiyyvdqiq dgvntiksav esygswddvt tvsignelvn gnqatpsqvg 241 qyidsgrsal kaagytgpvv svdtfiavin npelcdysdy mavnahayfd kntvaqdsgk 301 wlleqiqrvw tacdgkknvv itesgwpskg etygvavpsk enqkdavsai tsscgadtfl 361 ftafndywka dgaygvekyw gilsne // LOCUS NP_011796 271 aa linear PLN 30-JUN-2025 DEFINITION telomerase inhibitor [Saccharomyces cerevisiae S288C]. ACCESSION NP_011796 VERSION NP_011796.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181409.1 REFERENCE 1 (residues 1 to 271) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 271) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 271) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 271) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08368. Method: conceptual translation. FEATURES Location/Qualifiers source 1..271 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..271 /product="telomerase inhibitor" /calculated_mol_wt="31181" Region 25..70 /region_name="G-patch" /note="G-patch domain; pfam01585" /db_xref="CDD:396249" CDS 1..271 /gene="PXR1" /locus_tag="YGR280C" /gene_synonym="GNO1" /coded_by="NM_001181409.1:1..816" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:12107183]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12107183]" /experiment="EXISTENCE:genetic interaction:GO:0010521 telomerase inhibitor activity [PMID:14977919]" /experiment="EXISTENCE:genetic interaction:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:14977919]" /experiment="EXISTENCE:mutant phenotype:GO:0000494 box C/D sno(s)RNA 3'-end processing [PMID:12107183]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:24823796]" /experiment="EXISTENCE:mutant phenotype:GO:0010521 telomerase inhibitor activity [PMID:14977919]" /experiment="EXISTENCE:mutant phenotype:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:14977919]" /experiment="EXISTENCE:physical interaction:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:14977919]" /note="Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain" /db_xref="GeneID:853197" /db_xref="SGD:S000003512" ORIGIN 1 mglaatrtkq rfgldprnta wsndtsrfgh qflekfgwkp gmglglspmn sntshikvsi 61 kddnvglgak lkrkdkkdef dngecagldv fqrilgrlng keskiseeld tqrkqkiidg 121 kwgihfvkge vlastwdpkt hklrnysnak krkregddse deddddkedk dsdkkkhkkh 181 kkhkkdkkkd kkdkkehkkh kkeekrlkke kraektketk ktsklksses asnipdavnt 241 rlsvrskwik qkraalmdsk alneifmitn d // LOCUS NP_011797 1477 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette transporter YOR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011797 VERSION NP_011797.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181410.3 REFERENCE 1 (residues 1 to 1477) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1477) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1477) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1477) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08369. On Jul 30, 2012 this sequence version replaced NP_011797.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1477 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1477 /product="ATP-binding cassette transporter YOR1" /EC_number="7.2.2.2" /EC_number="7.6.2.3" /calculated_mol_wt="166598" Region 92..1468 /region_name="MRP_assoc_pro" /note="multi drug resistance-associated protein (MRP); TIGR00957" /db_xref="CDD:188098" CDS 1..1477 /gene="YOR1" /locus_tag="YGR281W" /gene_synonym="YRS1" /coded_by="NM_001181410.3:1..4434" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9575223]" /experiment="EXISTENCE:direct assay:GO:0008559 ABC-type xenobiotic transporter activity [PMID:23270647]" /experiment="EXISTENCE:direct assay:GO:0042908 xenobiotic transport [PMID:23270647]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0008559 ABC-type xenobiotic transporter activity [PMID:23270647]" /experiment="EXISTENCE:mutant phenotype:GO:0042908 xenobiotic transport [PMID:23270647]" /note="Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR)" /db_xref="GeneID:853198" /db_xref="SGD:S000003513" ORIGIN 1 mtitvgdavs etelenksqn vvlspkasas sdistdvdkd tssswddksl lptgeyivdr 61 nkpqtylnsd diekvtesdi fpqkrlfsfl hskkipevpq tdderkiypl fhtniisnmf 121 fwwvlpilrv gykrtiqpnd lfkmdprmsi etlyddfekn miyyfektrk kyrkrhpeat 181 eeevmenakl pkhtvlrall ftfkkqyfms ivfailanct sgfnpmitkr liefveekai 241 fhsmhvnkgi gyaigaclmm fvngltfnhf fhtsqltgvq aksiltkaam kkmfnasnya 301 rhcfpngkvt sfvttdlari efalsfqpfl agfpailaic ivllivnlgp ialvgigiff 361 ggffislfaf klilgfriaa niftdarvtm mrevlnnikm ikyytweday ekniqdirtk 421 eiskvrkmql srnfliamam slpsiaslvt flamykvnkg grqpgnifas lslfqvlslq 481 mfflpiaigt gidmiiglgr lqslleaped dpnqmiemkp spgfdpklal kmthcsfewe 541 dyelndaiee akgeakdegk knkkkrkdtw gkpsastnka krldnmlkdr dgpedlekts 601 frgfkdlnfd ikkgefimit gpigtgkssl lnamagsmrk tdgkvevngd llmcgypwiq 661 nasvrdniif gspfnkekyd evvrvcslka dldilpagdm teigergitl sggqkarinl 721 arsvykkkdi ylfddvlsav dsrvgkhimd ecltgmlank trilathqls lierasrviv 781 lgtdgqvdig tvdelkarnq tlinllqfss qnsekedeeq eavvagelgq lkyesevkel 841 telkkkatem sqtansgkiv adghtsskee ravnsislki yreyikaavg kwgfialply 901 ailvvgttfc slfssvwlsy wtenkfknrp psfymglysf fvfaafifmn gqftilcamg 961 imaskwlnlr avkrilhtpm syidttplgr ilnrftkdtd sldneltesl rlmtsqfani 1021 vgvcvmcivy lpwfaiaipf llvifvliad hyqssgreik rleavqrsfv ynnlnevlgg 1081 mdtikayrsq erflaksdfl inkmneagyl vvvlqrwvgi fldmvaiafa liitllcvtr 1141 afpisaasvg vlltyvlqlp gllntilram tqtendmnsa erlvtyatel pleasyrkpe 1201 mtppeswpsm geiifenvdf ayrpglpivl knlnlniksg ekigicgrtg agkstimsal 1261 yrlneltagk ilidnvdisq lglfdlrrkl aiipqdpvlf rgtirknldp fnertddelw 1321 dalvrggaia kddlpevklq kpdengthgk mhkfhldqav eeegsnfslg erqllaltra 1381 lvrqskilil deatssvdye tdgkiqtriv eefgdctilc iahrlktivn ydrilvlekg 1441 evaefdtpwt lfsqedsifr smcsrsgive ndfenrs // LOCUS NP_011798 313 aa linear PLN 30-JUN-2025 DEFINITION glucan 1,3-beta-glucosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011798 VERSION NP_011798.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181411.1 REFERENCE 1 (residues 1 to 313) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 313) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 313) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 313) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08370. Method: conceptual translation. FEATURES Location/Qualifiers source 1..313 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..313 /product="glucan 1,3-beta-glucosidase" /EC_number="3.2.1.58" /calculated_mol_wt="33988" Region 27..310 /region_name="Glyco_hydro_17" /note="Glycosyl hydrolases family 17; pfam00332" /db_xref="CDD:366033" CDS 1..313 /gene="BGL2" /locus_tag="YGR282C" /gene_synonym="SCW9" /coded_by="NM_001181411.1:1..942" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:2509432|PMID:9748433]" /experiment="EXISTENCE:direct assay:GO:0042973 glucan endo-1,3-beta-D-glucosidase activity [PMID:8458852]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:16986442]" /experiment="EXISTENCE:mutant phenotype:GO:0042973 glucan endo-1,3-beta-D-glucosidase activity [PMID:7851411]" /note="Endo-beta-1,3-glucanase; major component of the cell wall involved in cell wall maintenance; involved in incorporation of newly synthesized mannoprotein molecules into the cell wall; C-terminal region can form fibrillar structures and has amyloidogenic potential" /db_xref="GeneID:853199" /db_xref="SGD:S000003514" ORIGIN 1 mrfsttlata atalfftasq vsaigelafn lgvknndgtc kstsdyetel qalksytstv 61 kvyaasdcnt lqnlgpaaea egftifvgvw ptddshyaae kaalqtylpk ikestvagfl 121 vgsealyrnd ltasqlsdki ndvrsvvadi sdsdgksysg kqvgtvdswn vlvagynsav 181 ieasdfvman afsywqgqtm qnasysffdd imqalqviqs tkgstditfw vgetgwptdg 241 tnfessypsv dnakqfwkeg icsmrawgvn vivfeafded wkpntsgtsd vekhwgvfts 301 sdnlkysldc dfs // LOCUS NP_011799 341 aa linear PLN 30-JUN-2025 DEFINITION putative methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011799 VERSION NP_011799.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181412.3 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08371. On Jul 30, 2012 this sequence version replaced NP_011799.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..341 /product="putative methyltransferase" /calculated_mol_wt="38415" Region 40..336 /region_name="Methyltrn_RNA_3" /note="Putative RNA methyltransferase; pfam02598" /db_xref="CDD:460611" CDS 1..341 /gene="UPA1" /locus_tag="YGR283C" /coded_by="NM_001181412.3:1..1026" /experiment="EXISTENCE:curator inference:GO:0032259 methylation [PMID:21858014|PMID:22650761]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /note="Putative SPOUT methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; contributes to the methylation of Cse4-R37 in G2/M phase; overexpression leads to chromosomal instability; null mutant is resistant to fluconazole; GFP-fusion protein localizes to the nucleolus; YGR283C has a paralog, YMR310C, that arose from the whole genome duplication" /db_xref="GeneID:853200" /db_xref="SGD:S000003515" ORIGIN 1 mavkhksesl kheegaakka ktgllklkki mdiesnvvky sicipttvid ncnnleqvtf 61 tayqiartav lfnvqeiivl dqskdkkhek ksrsketisd clllatllqy fvtppnlldt 121 tfkkknklyl kcastfppln qlpfmnasae qhykeglsia rdsskgksdd altnlvyigk 181 nqiitlsnqn ipntarvtvd terkevvspi daykgkplgy hvrmastlne vsegytkivw 241 vnsgdfhyde elskyhkvet klpyiaklkk sstsekpcni llifgkwghl krcfrrsdle 301 ssslhhyfsg qlqfpasvpq gnipiqdslp ialtmfqrwa s // LOCUS NP_011800 310 aa linear PLN 30-JUN-2025 DEFINITION protein ERV29 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011800 VERSION NP_011800.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181413.3 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08372. On Jul 30, 2012 this sequence version replaced NP_011800.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..310 /product="protein ERV29" /calculated_mol_wt="34882" Region 48..310 /region_name="DoxX" /note="cl21527" /db_xref="CDD:451291" CDS 1..310 /gene="ERV29" /locus_tag="YGR284C" /coded_by="NM_001181413.3:1..933" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11157978]" /experiment="EXISTENCE:mutant phenotype:GO:0097020 COPII receptor activity [PMID:11711675]" /note="Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853201" /db_xref="SGD:S000003516" ORIGIN 1 msyrgpignf ggmpmsssqg pysggaqfrs nqnqstsgil kqwkhsfekf asriegltdn 61 avvyklkpyi pslsrffiva tfyedsfril sqwsdqifyl nkwkhypyff vvvflvvvtv 121 smligasllv lrkqtnyatg vlcacvisqa lvyglftgss fvlrnfsvig glliafsdsi 181 vqnkttfgml pelnskndka kgyllfagri livlmfiaft fskswftvvl tiigticfai 241 gyktkfasim lgliltfyni tlnnywfynn tkrdflkyef yqnlsiiggl llvtntgage 301 lsvdekkkiy // LOCUS NP_011801 433 aa linear PLN 30-JUN-2025 DEFINITION zuotin [Saccharomyces cerevisiae S288C]. ACCESSION NP_011801 VERSION NP_011801.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181414.1 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08373. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..433 /product="zuotin" /calculated_mol_wt="48889" Region 14..50 /region_name="zuotin_NTD" /note="N-terminal domain of fungal ribosome associated J-protein zuotin and similar proteins; cd23953" /db_xref="CDD:467935" Region 50..433 /region_name="ZUO1" /note="Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]; COG5269" /db_xref="CDD:227594" CDS 1..433 /gene="ZUO1" /locus_tag="YGR285C" /coded_by="NM_001181414.1:1..1302" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20368619|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005840 ribosome [PMID:17242366]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:25380751]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0005730 nucleolus [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:15456889]" /experiment="EXISTENCE:mutant phenotype:GO:0006452 translational frameshifting [PMID:16607023]" /experiment="EXISTENCE:mutant phenotype:GO:0051083 'de novo' cotranslational protein folding [PMID:11274393]" /note="Ribosome-associated co-chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains with Ssz1p and Ssb1/2p; subunit of the ribosome-associated complex (RAC) that stimulates Ssb1/2p ATPase activity to facilitate interaction with nascent polypeptide chains emerging from the ribosome exit tunnel; regulates translation upon inhibition of TORC1; contains a DnaJ domain; human gene DNAJC2 partially complements the yeast zuo1 null mutant" /db_xref="GeneID:853202" /db_xref="SGD:S000003517" ORIGIN 1 mfslptltsd itvevnssat ktpfvrrpve pvgkfflqha qrtlrnhtws eferieaekn 61 vktvdesnvd pdellfdtel adedllthda rdwktadlya amglsklrfr atesqiikah 121 rkqvvkyhpd kqsaaggsld qdgffkiiqk afetltdsnk raqydscdfv advpppkkgt 181 dydfyeawgp vfeaearfsk ktpipslgnk dsskkeveqf yafwhrfdsw rtfefldedv 241 pddssnrdhk ryierknkaa rdkkktadna rlvklverav sedprikmfk eeekkekerr 301 kwereagara eaeakakaea eakakaesea kanasakadk kkakeaakaa kkknkrairn 361 sakeadyfgd adkattideq vglivdslnd eelvstadki kanaagakev lkesaktivd 421 sgklpsslls yfv // LOCUS NP_011802 375 aa linear PLN 30-JUN-2025 DEFINITION biotin synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011802 VERSION NP_011802.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181415.1 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08374. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..375 /product="biotin synthase" /EC_number="2.8.1.6" /calculated_mol_wt="41753" Region 9..375 /region_name="PLN02389" /note="biotin synthase" /db_xref="CDD:215219" CDS 1..375 /gene="BIO2" /locus_tag="YGR286C" /coded_by="NM_001181415.1:1..1128" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0004076 biotin synthase activity [PMID:10525840]" /experiment="EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:10525840]" /note="Biotin synthase; catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant" /db_xref="GeneID:853203" /db_xref="SGD:S000003518" ORIGIN 1 mmstiyrhls tarpaltkya tnaavkstta sseastlgal qyalsldeps hswtksqlke 61 iyhtpllelt haaqlqhrkw hdptkvqlct lmniksggcs edckycaqss rndtglkaek 121 mvkvdevike aeeakrngst rfclgaawrd mkgrksamkr iqemvtkvnd mgletcvtlg 181 mvdqdqakql kdagltaynh nidtsrehys kvittrtydd rlqtiknvqe sgikactggi 241 lglgeseddh igfiytlsnm sphpeslpin rlvaikgtpm aeeladpksk klqfdeilrt 301 iatarivmpk aiirlaagry tmketeqfvc fmagcnsift gkkmlttmcn gwdedkamla 361 kwglqpmeaf kydrs // LOCUS NP_011803 589 aa linear PLN 30-JUN-2025 DEFINITION oligo-1,6-glucosidase IMA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011803 VERSION NP_011803.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181416.3 REFERENCE 1 (residues 1 to 589) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 589) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 589) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 589) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08375. On Jul 30, 2012 this sequence version replaced NP_011803.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..589 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..589 /product="oligo-1,6-glucosidase IMA1" /EC_number="3.2.1.10" /calculated_mol_wt="68461" Region 16..503 /region_name="AmyAc_SI_OligoGlu_DGase" /note="Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; cd11333" /db_xref="CDD:200472" Site order(30,32,34,38) /site_type="other" /note="Ca binding site [ion binding]" /db_xref="CDD:200472" Site order(69,72,109,112,159,178,182,215,277,442) /site_type="active" /db_xref="CDD:200472" Site order(215,277,352) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:200472" Region 514..585 /region_name="Malt_amylase_C" /note="Maltogenic Amylase, C-terminal domain; cl02706" /db_xref="CDD:445893" CDS 1..589 /gene="IMA1" /locus_tag="YGR287C" /coded_by="NM_001181416.3:1..1770" /experiment="EXISTENCE:direct assay:GO:0004574 oligo-1,6-glucosidase activity [PMID:20471265|PMID:15291818]" /experiment="EXISTENCE:direct assay:GO:0004575 sucrose alpha-glucosidase activity [PMID:24649402]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:genetic interaction:GO:0046352 disaccharide catabolic process [PMID:20471265]" /experiment="EXISTENCE:mutant phenotype:GO:0046352 disaccharide catabolic process [PMID:20562106]" /note="Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); required for isomaltose utilization; preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; member of the IMA isomaltase family" /db_xref="GeneID:853204" /db_xref="SGD:S000003519" ORIGIN 1 mtissahpet epkwwkeatf yqiypasfkd snddgwgdmk giaskleyik elgadaiwis 61 pfydspqddm gydianyekv wptygtnedc faliekthkl gmkfitdlvi nhcssehewf 121 kesrssktnp krdwffwrpp kgydaegkpi ppnnwksyfg gsawtfdekt qefylrlfcs 181 tqpdlnwene dcrkaiyesa vgywldhgvd gfridvgsly skvvglpdap vvdknstwqs 241 sdpytlngpr ihefhqemnq firnrvkdgr eimtvgemqh asdetkrlyt sasrhelsel 301 fnfshtdvgt splfrynlvp felkdwkial aelfryingt dcwstiylen hdqprsitrf 361 gddspknrvi sgkllsvlls altgtlyvyq gqelgqinfk nwpvekyedv eirnnynaik 421 eehgenseem kkfleaiali srdhartpmq wsreepnagf sgpsakpwfy lndsfregin 481 vedeikdpns vlnfwkealk frkahkditv ygydfefidl dnkklfsftk kynnktlfaa 541 lnfssdatdf kipnddssfk lefgnypkke vdassrtlkp wegriyise // LOCUS NP_011804 473 aa linear PLN 30-JUN-2025 DEFINITION transcription factor MAL13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011804 VERSION NP_011804.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181417.1 REFERENCE 1 (residues 1 to 473) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 473) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 473) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 473) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08376. Method: conceptual translation. FEATURES Location/Qualifiers source 1..473 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..473 /product="transcription factor MAL13" /calculated_mol_wt="54194" Region 11..48 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(12,17..20,22,25,34) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(13,16,23,29,32,39) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 84..>351 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..473 /gene="MAL13" /locus_tag="YGR288W" /coded_by="NM_001181417.1:1..1422" /experiment="EXISTENCE:mutant phenotype:GO:0005975 carbohydrate metabolic process [PMID:3025617]" /note="MAL-activator protein; part of complex locus MAL1; nonfunctional in genomic reference strain S288C" /db_xref="GeneID:853205" /db_xref="SGD:S000003520" ORIGIN 1 mtltkqtcak qacdccrirr vkcdgkrpcs sclqnsldct ylqpsrkrgp ksirlrslkr 61 iaevqresgp ntiatapviy krvpkklidq clrlyhdnly viwpllsydd lhklleekyn 121 dnyvywflta lsaatlsdlq teikseeevt ftgkqlsnlc isscqqfddl dnsnifnimt 181 yyclhrsfaq isnartsyrl cceavglitv aglhreetyg sltfeeqqlr rklyylllmt 241 eryyaiylhc atsldatiap pqlelvtdpq lsmdsflemi rvftvpgkcf fdalaadstd 301 ascteeslkk iwnelhttss eiepwsngyi disfsrhwir ilawklayqm rgsnfslnan 361 ngqipieiar dmlidtyltp enlydvhgpg vpvktleiat alvdivgqyd hnmkleawnv 421 lhdvckfafs lnhynndmlk rfstkcqnal itlpiskplq ldgypkdned idp // LOCUS NP_011805 616 aa linear PLN 30-JUN-2025 DEFINITION alpha-glucoside permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_011805 VERSION NP_011805.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181418.3 REFERENCE 1 (residues 1 to 616) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 616) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 616) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 616) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08377. On Jul 30, 2012 this sequence version replaced NP_011805.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..616 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..616 /product="alpha-glucoside permease" /calculated_mol_wt="67849" Region 81..563 /region_name="SP" /note="MFS transporter, sugar porter (SP) family; TIGR00879" /db_xref="CDD:273317" Site order(120..121,124..125,128,171,221..222,224..226,229,249, 252..253,256,328,359..360,363..365,387,415,419,475..476, 480,484,500,503..504,507..508,511) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:349949" CDS 1..616 /gene="MAL11" /locus_tag="YGR289C" /gene_synonym="AGT1" /coded_by="NM_001181418.3:1..1851" /experiment="EXISTENCE:direct assay:GO:0005352 alpha-glucoside:proton symporter activity [PMID:12702465]" /experiment="EXISTENCE:direct assay:GO:0015574 trehalose transmembrane transporter activity [PMID:12702465]" /experiment="EXISTENCE:direct assay:GO:0015771 trehalose transport [PMID:12702465]" /experiment="EXISTENCE:genetic interaction:GO:0015768 maltose transport [PMID:6371820]" /experiment="EXISTENCE:mutant phenotype:GO:0005364 maltose:proton symporter activity [PMID:1999393|PMID:8594329]" /experiment="EXISTENCE:mutant phenotype:GO:0015768 maltose transport [PMID:8594329]" /experiment="EXISTENCE:mutant phenotype:GO:0046352 disaccharide catabolic process [PMID:20562106]" /note="High-affinity maltose transporter (alpha-glucoside transporter); inducible; encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization" /db_xref="GeneID:853207" /db_xref="SGD:S000003521" ORIGIN 1 mkniislvsk kkaasknedk nisessrdiv nqqevfnted feegkkdsaf eldhlefttn 61 saqlgdsded nenvinemna tddaneanse eksmtlkqal lkypkaalws ilvsttlvme 121 gydtallsal yalpvfqrkf gtlngegsye itsqwqigln mcvlcgemig lqittymvef 181 mgnrytmita lglltayifi lyyckslami avgqilsaip wgcfqslavt yasevcplal 241 ryymtsysni cwlfgqifas gimknsqenl gnsdlgyklp falqwiwpap lmigiffape 301 spwwlvrkdr vaearkslsr ilsgkgaekd iqvdltlkqi eltiekerll asksgsffnc 361 fkgvngrrtr lacltwvaqn ssgavllgys tyfferagma tdkaftfsli qyclglagtl 421 cswvisgrvg rwtiltygla fqmvclfiig gmgfgsgssa sngaggllla lsffynagig 481 avvycivaei psaelrtkti vlaricynlm avinailtpy mlnvsdwnwg aktglywggf 541 tavtlawvii dlpettgrtf seinelfnqg vparkfastv vdpfgkgktq hdsladesis 601 qsssikqrel naadkc // LOCUS NP_011808 584 aa linear PLN 30-JUN-2025 DEFINITION alpha-glucosidase MAL12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011808 VERSION NP_011808.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181421.3 REFERENCE 1 (residues 1 to 584) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 584) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 584) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 584) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08378. On Jul 30, 2012 this sequence version replaced NP_011808.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..584 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..584 /product="alpha-glucosidase MAL12" /EC_number="3.2.1.20" /calculated_mol_wt="67963" Region 15..501 /region_name="AmyAc_SI_OligoGlu_DGase" /note="Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; cd11333" /db_xref="CDD:200472" Site order(29,31,33,37) /site_type="other" /note="Ca binding site [ion binding]" /db_xref="CDD:200472" Site order(68,71,108,111,158,177,181,214,276,439) /site_type="active" /db_xref="CDD:200472" Site order(214,276,349) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:200472" Region 511..583 /region_name="Malt_amylase_C" /note="Maltogenic Amylase, C-terminal domain; pfam16657" /db_xref="CDD:435493" CDS 1..584 /gene="MAL12" /locus_tag="YGR292W" /coded_by="NM_001181421.3:1..1755" /experiment="EXISTENCE:direct assay:GO:0004558 alpha-1,4-glucosidase activity [PMID:20471265]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0033934 glucan 1,4-alpha-maltotriohydrolase activity [PMID:20471265]" /experiment="EXISTENCE:genetic interaction:GO:0000025 maltose catabolic process [PMID:20471265]" /experiment="EXISTENCE:genetic interaction:GO:0005987 sucrose catabolic process [PMID:20471265]" /note="Maltase (alpha-D-glucosidase); inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose" /db_xref="GeneID:853209" /db_xref="SGD:S000003524" ORIGIN 1 mtisdhpete pkwwkeatiy qiypasfkds nndgwgdlkg itsklqyikd lgvdaiwvcp 61 fydspqqdmg ydisnyekvw ptygtnedcf elidkthklg mkfitdlvin hcstehewfk 121 esrssktnpk rdwffwrppk gydaegkpip pnnwksffgg sawtfdettn efylrlfasr 181 qvdlnwened crraifesav gfwldhgvdg fridtaglys krpglpdspi fdktsklqhp 241 nwgshngpri heyhqelhrf mknrvkdgre imtvgevahg sdnalytsaa ryevsevfsf 301 thvevgtspf frynivpftl kqwkeaiasn flfingtdsw attyienhdq arsitrfadd 361 spkyrkisgk lltllecslt gtlyvyqgqe igqinfkewp iekyedvdvk nnyeiikksf 421 gknskemkdf fkgiallsrd hsrtpmpwtk dkpnagftgp dvkpwfllne sfeqginveq 481 esrdddsvln fwkralqark kykelmiygy dfqfidldsd qifsftkeye dktlfaalnf 541 sgeeiefslp regaslsfil gnyddtdvss rvlkpwegri ylvk // LOCUS NP_011810 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011810 VERSION NP_011810.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181423.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08379. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..120 /product="seripauperin PAU12" /calculated_mol_wt="12688" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU12" /locus_tag="YGR294W" /coded_by="NM_001181423.1:1..363" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to both the endoplasmic reticulum and vacuole" /db_xref="GeneID:853210" /db_xref="SGD:S000003526" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ysfqaahpte 61 typveiaeav fnygdfttml tgiapdqvtr mitgvpwyss rlkpaissal skdgiytian // LOCUS NP_011811 381 aa linear PLN 30-JUN-2025 DEFINITION Cos6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011811 VERSION NP_011811.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181424.1 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08380. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..381 /product="Cos6p" /calculated_mol_wt="45547" Region 76..167 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 262..353 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..381 /gene="COS6" /locus_tag="YGR295C" /coded_by="NM_001181424.1:1..1146" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:25942624]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /db_xref="GeneID:853212" /db_xref="SGD:S000003527" ORIGIN 1 mkenelknek svdvlsvkql esqktvlpqd lfrssftwfc yeiykslvfr iwmllwlpls 61 vwwklsnnwi yplmvsllvl fwgpvfvlvi frlsrkrsls kqltqfckei tkntpssdph 121 dwevvaanln syfyenkawn tkyfffsams cqeafrttll epfslkkdea akvksfkdsv 181 pyieealevy ftevekqwkl fnsekswspv gledaklpke ayrfkltwvl krifnrrclp 241 lflfylhnvf isrndgtiar plflvvlffi mtrdfrnmrm ivlsvkmehk mqflstiine 301 qesgangwde iakkmnrylf ekkvwkneef ffdgidcewf fshffyrvls akksmralsl 361 nvelwpyike aqlscseesl a // LOCUS NP_011812 1859 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase protein 1 copy 3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011812 VERSION NP_011812.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181425.3 REFERENCE 1 (residues 1 to 1859) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1859) AUTHORS Tettelin,H., Agostoni Carbone,M.L., Albermann,K., Albers,M., Arroyo,J., Backes,U., Barreiros,T., Bertani,I., Bjourson,A.J., Bruckner,M., Bruschi,C.V., Carignani,G., Castagnoli,L., Cerdan,E., Clemente,M.L., Coblenz,A., Coglievina,M., Coissac,E., Defoor,E., Del Bino,S., Delius,H., Delneri,D., de Wergifosse,P., Dujon,B., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome VII JOURNAL Nature 387 (6632 SUPPL), 81-84 (1997) PUBMED 9169869 REFERENCE 3 (residues 1 to 1859) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1859) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08381. On Jul 30, 2012 this sequence version replaced NP_011812.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1859 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VII" Protein 1..1859 /product="Y' element ATP-dependent helicase protein 1 copy 3" /EC_number="3.6.4.12" /calculated_mol_wt="210985" Region 38..152 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 854..1026 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" Region 1101..1196 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1859 /gene="YRF1-3" /locus_tag="YGR296W" /gene_synonym="YRF1" /coded_by="NM_001181425.3:1..5580" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9837911]" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:9837911]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]" /note="Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" /db_xref="GeneID:853213" /db_xref="SGD:S000003528" ORIGIN 1 meieneqict ciaqilhlln sliitflddd ktetgqsfvy idgflvkkhn nqhtivnfet 61 yknkmkvsdr rkfekanfde fesalnnknd lvhcpsitlf esiptevrsf yedeksglik 121 vvkfrtgamd rkrsfekivv svmvgknvqk fltfvedepd fqggpipsky lipkkinlmv 181 ytlfqvhtlk fnrkdydtls lfylnrgyyn elsfrvlerc yeiasarpnd sstmrtftdf 241 vsgtpivrgl qkstirkygy nlapymflll hvdelsifsa yqaslpgekk vdterlkrdl 301 cprkpteiky fsqicndmmn kkdrlgdilh iilracalnf gagprggagd eedrsitnee 361 piipsvdehg lkvcklrspn tprrlrktld avkallvssc actardldif ddnngvamwk 421 wikilyheva qetalkdsyr itlvpssdgv svcgklfnre yvrgfyfack aqfdnlweel 481 ndcfymptvv diaslilrnr evlfrepkrg ideylendsf lqmipvkyre ivlpklrrdt 541 nkmtaalknk vtvaideltv plmwmihfav gypyrypelq llafagpqrn vyvddttrri 601 qlytdynkng sseprlktld gltsdyvfyf vtvlrqmqic algnsydafn hdpwmdvvgf 661 edpdqvtnrd isrivlysym flntakgclv eyatfrqymr elpknapqkl nfremrqgli 721 algrhcvgsr fetdlyesat selmanhsvq tgrniygvds fsltsvsgtt atllqerase 781 rwiqwlgles dyhcsfsstr naedvvagea assdhhqkis rvtrkrprep kstndilvag 841 qklfgssfef rdlhqlrlch eiymadtpsv avqappgygk telfhlplia laskgdvkyv 901 sflfvpytvl lancmirlsr cgclnvapvr nfieegcdgv tdlyvgiydd lastnftdri 961 aawenivect frtnnvklgy livdefhnfe tevyrqsqfg gitnldfdaf ekaiflsgta 1021 peavadaalq rigltglakk smdinelkrs edlsrglssy ptrmfnlike ksevplghvh 1081 kiwkkvesqp eealklllal feiepeskai vvasttneve elacswrkyf rvvwihgklg 1141 aaekvsrtke fvtdgsmrvl igtklvtegi dikqlmmvim ldnrlniiel iqgvgrlrdg 1201 glcyllsrkn swaarnrkge lppikegcit eqvrefygle skkgkkgqhv gccgsrtdls 1261 adtvelierm drlaekqata smsivalpss fqesnssdrc rkycssdeds dtcihgsana 1321 stnattnsst natttastnv rtsatttasi nvrtsattte stnsstnatt tastnvrtsa 1381 tttasinvrt satttestns ntsatttest dsntsattte stdsntsatt tastnsstna 1441 tttastnsst natttestna sakedankdg naednrfhpv tdinkesykr kgsqmvller 1501 kklkaqfpnt senmnvlqfl gfrsdeikhl flygidvyfc pegvftqygl ckgcqkmfel 1561 cvcwagqkvs yrrmaweala vermlrndee ykeylediep yhgdpvgylk yfsvkrgeiy 1621 sqiqrnyawy laitrrreti svldstrgkq gsqvfrmsgr qikelyykvw snlresktev 1681 lqyflnwdek kcreeweakd dtvfvealek vgvfqrlrsm tsaglqgpqy vklqfsrhhr 1741 qlrsryelsl gmhlrdqlal gvtpskvphw taflsmligl fcnktfrqkl eylleqisev 1801 wllphwldla nvevlaadnt rvplymlmva vhkeldsddv pdgrfdillc rdssrevge // LOCUS NP_011813 697 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL050C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011813 VERSION NP_011813.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179130.1 REFERENCE 1 (residues 1 to 697) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 697) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 697) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 697) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 697) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 697) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 697) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06637. Method: conceptual translation. FEATURES Location/Qualifiers source 1..697 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..697 /product="uncharacterized protein" /calculated_mol_wt="78895" Region 6..163 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Region 494..>547 /region_name="YccJ" /note="YccJ-like protein; cl23921" /db_xref="CDD:451607" CDS 1..697 /locus_tag="YHL050C" /coded_by="NM_001179130.1:1..2094" /note="hypothetical protein; potential Cdc28p substrate" /db_xref="GeneID:856335" /db_xref="SGD:S000001042" ORIGIN 1 madtpsvavq appgygktel fhlplialas kgdveyvsfl fvpytvllan cmirlgrcgc 61 lnvapvrnfi eegcdgvtdl yvgiyddlas tnftdriaaw enivectfrt nnvklgyliv 121 delhnfetev yrqsqfggit nldfdafeka iflsgtapea vadaalqrig ltglakksmd 181 inelkrsedl srglssyptr mfnlikeksk vplgtnattt astnvrtsat ttasinvrts 241 atttasinvr tsatttestn sntnatttes tnsstnattt astnsstnat ttestnasak 301 edankdgnae dnrfhpvtdi nkepykrkgs qmvllerkkl kaqfpntsen mnvlqflgfr 361 sdeikhlfly gidiyfcpeg vftqyglckg cqkmfelcvc wagqkvsyrr mawealaver 421 mlrndeeyke ylediepyhg dpvgylkffs vkrreiysqi qrnyawylai trrretisvl 481 dstrgkqgsq vfrmsgrqik elyykvwsnl resktevlqy flnwdekkcq eeweakddtv 541 fvealekvgv fqrlrsmtsa glqgpqyvkl qfsrhhrqlr sryelslgmh lrdqlalgvt 601 pskvphwtaf lsmliglfyn ktfrqkleyl leqisevwll phwldlanve vlaadntrvp 661 lymlmvavhk eldsddvpdg rfdiillcrd ssrevge // LOCUS NP_011814 271 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL049C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011814 VERSION NP_011814.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179129.1 REFERENCE 1 (residues 1 to 271) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 271) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 271) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 271) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06638. Method: conceptual translation. FEATURES Location/Qualifiers source 1..271 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..271 /product="uncharacterized protein" /calculated_mol_wt="31374" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" CDS 1..271 /locus_tag="YHL049C" /coded_by="NM_001179129.1:1..816" /note="hypothetical protein" /db_xref="GeneID:856336" /db_xref="SGD:S000001041" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekivvsvmv gknvqkfltf vedepdfqgg pipskylipk kinlmvytlf 121 qvhtlkfnrk dydtlslfyl nrgyynelsf rvlercheia sarpndsstm rtftdfvsga 181 pivrslqkst irkygynlap hmflllhvde lsifsayqas lpgekkvdte rlkrdlcprk 241 pteikyfsqi cndmmnkkdr lgdvlhvccp s // LOCUS NP_878084 44 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL048C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878084 VERSION NP_878084.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184650.1 REFERENCE 1 (residues 1 to 44) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 44) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 44) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 44) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06639. Method: conceptual translation. FEATURES Location/Qualifiers source 1..44 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..44 /product="uncharacterized protein" /calculated_mol_wt="4965" CDS 1..44 /locus_tag="YHL048C-A" /coded_by="NM_001184650.1:1..135" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /note="hypothetical protein; identified by expression profiling and mass spectrometry; localizes to the peroxisome in a Pex5p-dependent manner in oleate" /db_xref="GeneID:1466524" /db_xref="SGD:S000028829" ORIGIN 1 mhdiwvitts pacfeilyky ckqkgrarmg glivkiirfn hasv // LOCUS NP_011815 381 aa linear PLN 30-JUN-2025 DEFINITION Cos8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011815 VERSION NP_011815.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179128.1 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 381) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06640. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..381 /product="Cos8p" /calculated_mol_wt="45749" Region 73..167 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 261..353 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..381 /gene="COS8" /locus_tag="YHL048W" /coded_by="NM_001179128.1:1..1146" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:12051917]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /db_xref="GeneID:856337" /db_xref="SGD:S000001040" ORIGIN 1 mkenevkdek svdvlsfkql efqktvlpqd vfrneltwfc yeiykslafr iwmllwlpls 61 vwwklssnwi hplivsllvl flgpffvlvi cglsrkrsls kqliqfckei tedtpssdph 121 dwevvaanln syfyenktwn tkyfffnams cqkafkttll epfslkkdes akvksfkdsv 181 pyieealqvy aagfdkewkl fntekeespf dlediqlpke ayrfkltwil krifnlrclp 241 lflyyflivy tsgnadlisr flfpvvmffi mtrdfqnmrm ivlsvkmehk mqflstiine 301 qesgangwde iakkmnrylf ekkvwnneef fydgldcewf frrffyrlls lkkpmwfasl 361 nvelwpyike aqsarnekpl k // LOCUS NP_011816 620 aa linear PLN 30-JUN-2025 DEFINITION siderophore transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_011816 VERSION NP_011816.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179127.2 REFERENCE 1 (residues 1 to 620) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 620) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 620) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 620) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06641. On Apr 26, 2011 this sequence version replaced NP_011816.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..620 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..620 /product="siderophore transporter" /calculated_mol_wt="69436" Region 69..581 /region_name="MFS_ARN_like" /note="Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; cd17322" /db_xref="CDD:340880" Site order(83..84,87..88,91,122,172..173,175..177,180,196, 199..200,203,362,365..366,369..371,374,402,406,460..461, 465,469,485,488..489,492..493,496) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340880" CDS 1..620 /gene="ARN2" /locus_tag="YHL047C" /gene_synonym="TAF1" /coded_by="NM_001179127.2:1..1863" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015343 siderophore-iron transmembrane transporter activity [PMID:10816729]" /experiment="EXISTENCE:direct assay:GO:0015891 siderophore transport [PMID:10816729]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:10816729]" /experiment="EXISTENCE:mutant phenotype:GO:0009237 siderophore metabolic process [PMID:10816729]" /experiment="EXISTENCE:mutant phenotype:GO:0015343 siderophore-iron transmembrane transporter activity [PMID:10748025|PMID:10816729]" /experiment="EXISTENCE:mutant phenotype:GO:0015891 siderophore transport [PMID:10816729]" /note="Transporter; member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C" /db_xref="GeneID:856338" /db_xref="SGD:S000001039" ORIGIN 1 mievpednrs sqtkrkntek ncnelmvdek mdddssprde mkdklkgtks liirkselma 61 kkydtwqlka iflfsafict faygldssir gtymtyamns ysahslistv svivlmisav 121 sqvifgglsd ifgrltlflv sivlyivgti iqsqaydvqr yaagavfyyv glvgvmlqvv 181 lmlsdnsslk wrlfytlips wpsiittwvs gsvveaanpl enwswniamw afifplccip 241 lilcmlhmrw kvrndvewke lqdeksyyqt hglvqmlvql fwkldvvgvl lftagvgcil 301 vpltlaggvs tnwrnskiig pfvlgfvlvp gfiywesrla lvpfapfkll kdrgvwaplg 361 imfficfvyq maagylytil vvavdesass atriinlysf vtavvapflg livtrssrlk 421 syiifggsly fitmglfyry rsgqdadggi iagmviwgls sclfdyptiv siqsvtshen 481 matvtalnyt vfriggavaa aisgaiwtqs lypkllhymg dadlataayg spltfilsnp 541 wgtpvrsamv eayrhvqkye vivalvfsap mflltfcvrd prltedfaqk lpdreyvqtk 601 eddpindwia krfakalgrs // LOCUS NP_011817 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011817 VERSION NP_011817.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179126.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 120) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06642. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..120 /product="seripauperin PAU13" /calculated_mol_wt="12749" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU13" /locus_tag="YHL046C" /coded_by="NM_001179126.1:1..363" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /db_xref="GeneID:856339" /db_xref="SGD:S000001038" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ymfqaahpte 61 typvevaeav fnygdfttml tgiapdqvtr mitgvpwyss rlkpaissal skdgiytitn // LOCUS NP_001403028 115 aa linear PLN 30-JUN-2025 DEFINITION Pxp3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001403028 VERSION NP_001403028.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001416099.1 REFERENCE 1 (residues 1 to 115) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 115) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 115) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 115) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAZ92295. Method: conceptual translation. FEATURES Location/Qualifiers source 1..115 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..115 /product="Pxp3p" /calculated_mol_wt="13184" CDS 1..115 /gene="PXP3" /locus_tag="YHL045W" /coded_by="NM_001416099.1:1..348" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /note="Peroxisomal hypothetical protein; last 10 C-terminal amino acids contains a novel PTS1 motif, both necessary and sufficient for Pex5p-dependent peroxisomal targeting; also localizes to the nucleus; PXP3 is not an essential gene" /db_xref="GeneID:856340" /db_xref="SGD:S000001037" ORIGIN 1 mkmllflnea cifidsvceg ivfwglclfv caecgnayyr garvpyktlf rafevsvfgq 61 keypnfrfgp syrflclspy sicckqppme evilyypspd sliknrkrvl gvayl // LOCUS NP_011819 235 aa linear PLN 30-JUN-2025 DEFINITION DUP240 family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011819 VERSION NP_011819.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179124.1 REFERENCE 1 (residues 1 to 235) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 235) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 235) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06643. Method: conceptual translation. FEATURES Location/Qualifiers source 1..235 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..235 /product="DUP240 family protein" /calculated_mol_wt="26841" Region <103..170 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..235 /gene="DFP4" /locus_tag="YHL044W" /coded_by="NM_001179124.1:1..708" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12101299]" /note="Putative integral membrane protein; member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern" /db_xref="GeneID:856341" /db_xref="SGD:S000001036" ORIGIN 1 mssellisns kprpeglrkl cegetvilpr ditpskcayf lkqnivfisy ifihiiitii 61 lnrlalsahg ntliiilaal litislflll llpylscsry klrcldddck fkllaevith 121 kpnmdlstwd riaydmnqfv ydrricadrs ffydgsycyq vfkklvatpy lvnsnmnsiy 181 adlemrsnga tnindsgnss lhielgtyif kalavfrnsv dkywedkype mgvtv // LOCUS NP_011820 170 aa linear PLN 30-JUN-2025 DEFINITION Ecm34p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011820 VERSION NP_011820.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179123.1 REFERENCE 1 (residues 1 to 170) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 170) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 170) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 170) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06644. Method: conceptual translation. FEATURES Location/Qualifiers source 1..170 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..170 /product="Ecm34p" /calculated_mol_wt="19681" Region <125..>169 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..170 /gene="ECM34" /locus_tag="YHL043W" /coded_by="NM_001179123.1:1..513" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; SWAT-GFP, seamless-GFP and mCherry C-terminal fusion proteins localize to the cytosol" /db_xref="GeneID:856342" /db_xref="SGD:S000001035" ORIGIN 1 megrksedek neaalacdvf essnaklpkn vfrssftwyc yevinrsafh iwlllcltli 61 vgwkvfsgig grrpsdsnmd gpqtkhkrnp gflrrhstiv ilvislavsf sweafkmyre 121 rtfgkqitqf akeiiksaps tdmeswdrva adfnsymyen klwnteyffc // LOCUS NP_011821 150 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL042W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011821 VERSION NP_011821.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179122.1 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 150) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06645. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..150 /product="uncharacterized protein" /calculated_mol_wt="17439" Region 30..122 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..150 /locus_tag="YHL042W" /coded_by="NM_001179122.1:1..453" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:31945465]" /note="Endoplasmic reticulum protein; member of DUP380 subfamily of conserved, often subtelomerically-encoded proteins; may contribute to maintenance of ER and nuclear morphology; null mutants have distorted nuclear envelope shape, and discontinuous, misshapen perinuclear ER" /db_xref="GeneID:856343" /db_xref="SGD:S000001034" ORIGIN 1 mkqrfsqvat viffvmsirs prnlgffftl alfvvlvcsq ewfsfemnrs csmkvehrmq 61 flstiisehq ksdvncwdqi akkmnvylfe qkvsgsdvff ldgadcerff ernflrylps 121 rksshpdlpi aellpyirka diacagkqli // LOCUS NP_001335736 149 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL041W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335736 VERSION NP_001335736.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348807.1 REFERENCE 1 (residues 1 to 149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 149) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80256. Method: conceptual translation. FEATURES Location/Qualifiers source 1..149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..149 /product="uncharacterized protein" /calculated_mol_wt="17423" CDS 1..149 /locus_tag="YHL041W" /coded_by="NM_001348807.1:1..450" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:856344" /db_xref="SGD:S000001033" ORIGIN 1 mhlysiakst tilrflrhil lpflhlsihf tsclcriiyv gwksfwkhff fcghkiktpl 61 fiasyamfla kqkiivtmfe vssvleklpq nillfhyplp skmgnnllms fltqrsidek 121 eidallhpna vyrfcnmrtt frtlssygk // LOCUS NP_011823 627 aa linear PLN 30-JUN-2025 DEFINITION siderophore transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_011823 VERSION NP_011823.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179120.1 REFERENCE 1 (residues 1 to 627) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 627) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 627) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 627) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06646. Method: conceptual translation. FEATURES Location/Qualifiers source 1..627 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..627 /product="siderophore transporter" /calculated_mol_wt="70768" Region 74..586 /region_name="MFS_ARN_like" /note="Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; cd17322" /db_xref="CDD:340880" Site order(88..89,92..93,96,127,177..178,180..182,185,201, 204..205,208,367,370..371,374..376,379,407,411,465..466, 470,474,490,493..494,497..498,501) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340880" CDS 1..627 /gene="ARN1" /locus_tag="YHL040C" /coded_by="NM_001179120.1:1..1884" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:17344478]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15719020]" /experiment="EXISTENCE:direct assay:GO:0031410 cytoplasmic vesicle [PMID:10748025]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015343 siderophore-iron transmembrane transporter activity [PMID:10802175]" /experiment="EXISTENCE:mutant phenotype:GO:0015891 siderophore transport [PMID:10802175]" /note="ARN family transporter for siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores; protein increases in abundance and relocalizes to the vacuole upon DNA replication stress" /db_xref="GeneID:856345" /db_xref="SGD:S000001032" ORIGIN 1 mesvhsrdpv keekkhvfmg mehelnpeth ndsnsdsygl pqlsekynal rqnrsliiqq 61 teiigsaynk wylqaillls aficgygygl dgniryiytg yatssysehs llstinvina 121 vvsaasqiiy arlsdvfgrl ylfisavily vvgtiiqsqa ydvqryaaga ifynagyvgv 181 ililliilsd fsslkwrlly qfvptwpfii ntwiagnits ranpvvnwsw dvgmwafifp 241 lscvpivlcm lhmqwrarkt pewhalkgqk syyqehgfik ilkqlfwmld vvgvllmgcs 301 lgcilvpltl aggvkttwnd srligpfvlg fvlipilwiw eyrfardpil pyrlvkdrav 361 wssmgisfli dfiyymaady lytvmivavn esvksatria tlssfvstva spffallvtr 421 ctrlkpfimf gcalwmvamg llyhfrggsq shsgiigalc vwgvgttlft ypvtvsvqsa 481 vshenmatvt alnytlyrig savgsavsga iwtqtlykqi lkrmgdvala ttayespytf 541 ietytwgtpq rnalmnayky vqrletival vfcvpliafs lclrdpkltd tvaveyiedg 601 eyvdtkdndp ildwfeklps kftfkre // LOCUS NP_011824 585 aa linear PLN 30-JUN-2025 DEFINITION protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011824 VERSION NP_011824.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179119.1 REFERENCE 1 (residues 1 to 585) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 585) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 585) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 585) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06647. Method: conceptual translation. FEATURES Location/Qualifiers source 1..585 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..585 /product="protein-lysine N-methyltransferase" /calculated_mol_wt="67322" Region 11..295 /region_name="SET_SpSET10-like" /note="SET domain found in Schizosaccharomyces pombe SET domain-containing protein 10 (SETD10) and similar proteins; cd19180" /db_xref="CDD:380957" Site order(34..35,213..214,241..246,280,292,294) /site_type="other" /note="putative SAM binding site" /db_xref="CDD:380957" Site order(34..35,54,211..216,241..245,254,278..281) /site_type="active" /note="putative active site [active]" /db_xref="CDD:380957" CDS 1..585 /gene="EFM1" /locus_tag="YHL039W" /coded_by="NM_001179119.1:1..1758" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:22522802]" /experiment="EXISTENCE:mutant phenotype:GO:0018026 peptidyl-lysine monomethylation [PMID:20510667|PMID:22522802|PMID:24517342]" /note="Lysine methyltransferase; involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:856346" /db_xref="SGD:S000001031" ORIGIN 1 mitqteldnc lqwaqnngaf idpkisfrit edagvsafvn ekfspkpdqa lirvpetlli 61 tsqqalsefs qaanerslln svtqlylskl kfgtdavhlk sfykpyldvl plhlpqpyfw 121 stdevmnlhg tdvyltmrdt lnklvkewrm lfqalsiehs sqdkqflslf qenkdsavvp 181 leqfcahing ckledsewns fvaylwsyci fnsrafprvi lgragtdrtn lnegflypiv 241 dllnhkndvp vrwemneqne lcfmsqtttf saqdelfnny gnisnekcll nygfwdssnk 301 fdfsrltlkl pstlvsglpv dfnksgnfvt ddgettilqf slkiseplpp vllalfayls 361 klkseetptv rsvlegidql tsvvsqrllf yknfkiktss tqklrphvik liklyyqdnk 421 kilnattekl svlqkkiysn nkefslsfkt ifkndkifan slllvfgain yedlitkdcl 481 ndalllwivk lindksnnqg gfikqtfkev sdsivieked vmeflpfykk yfpnlserip 541 eiysvgdwgi rqfivadtai drlvwirksn kepiflmkka ydlqi // LOCUS NP_011825 630 aa linear PLN 30-JUN-2025 DEFINITION Cbp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011825 VERSION NP_011825.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179118.1 REFERENCE 1 (residues 1 to 630) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 630) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 630) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 630) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06648. Method: conceptual translation. FEATURES Location/Qualifiers source 1..630 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..630 /product="Cbp2p" /calculated_mol_wt="73730" CDS 1..630 /gene="CBP2" /locus_tag="YHL038C" /coded_by="NM_001179118.1:1..1893" /experiment="EXISTENCE:direct assay:GO:0000372 Group I intron splicing [PMID:9092668]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10521416]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:2685564]" /experiment="EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:10521416]" /experiment="EXISTENCE:mutant phenotype:GO:0090615 mitochondrial mRNA processing [PMID:6348045]" /note="Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene" /db_xref="GeneID:856347" /db_xref="SGD:S000001030" ORIGIN 1 mvnwqtlfmv slrrqgsssr yrykfnmeni thqvfprckq afkktnlsye ycdlegvlyn 61 isltdlqkll lrdinapreh afkivrtdlt qksskkriqh weriapmfdh plslyeklfs 121 emdedfkpsf ewqqlirvrc kddklklqrv iwpksifsnf crgigvkkst ydrlleqnng 181 evpmfvnpan akplplfqvs deamigefdg igifpyfvdk hreffvtevd klktkiaspl 241 ctlnerkrie kanagrilan eegkpfylda nsattriagg nvvtlkqlle rsvshktlws 301 kqsnkdrtcp gdilratils ndfsirqlra efcknfilyn iftilqrnkk sirsfsgndn 361 apsfqfswnv wdsyiwkqyq etesmkiptd qaslinyktk ydsflhdlqt ysalvisemk 421 wnqfsifqnd ettlsrfehi tlilqtvltk skmirifqpn lykfmqddlr ptlmelvgft 481 esinatiepg faneqslqsa nglkklanql lyfeqeiyge kfrvnrpiql rpitlsanyk 541 ivildkknai peifqtllkf mtqittyfvk dlsevelhgh mhcidkkmld kskfmylyee 601 ksneevkaas pqkekivdni igllsndeeh // LOCUS NP_001335737 133 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL037C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335737 VERSION NP_001335737.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348812.1 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 133) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80257. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..133 /product="uncharacterized protein" /calculated_mol_wt="15322" CDS 1..133 /locus_tag="YHL037C" /coded_by="NM_001348812.1:1..402" /note="hypothetical protein; conserved among S. cerevisiae strains" /db_xref="GeneID:856348" /db_xref="SGD:S000001029" ORIGIN 1 myrssisiqv ficvlflpld sgrpliymid lsyicsdatv fsgksrviff snpicehtrg 61 nfylfylnyi intfapknrg trrckpfglh incrkkidcl hvqlsyilck nksrkrhmda 121 haitlawlah alt // LOCUS NP_011827 546 aa linear PLN 30-JUN-2025 DEFINITION Mup3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011827 VERSION NP_011827.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179116.1 REFERENCE 1 (residues 1 to 546) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 546) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 546) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 546) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06649. Method: conceptual translation. FEATURES Location/Qualifiers source 1..546 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..546 /product="Mup3p" /calculated_mol_wt="60489" Region 40..538 /region_name="2A0308" /note="L-type amino acid transporter; TIGR00911" /db_xref="CDD:273332" CDS 1..546 /gene="MUP3" /locus_tag="YHL036W" /coded_by="NM_001179116.1:1..1641" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015191 L-methionine transmembrane transporter activity [PMID:8893857]" /experiment="EXISTENCE:genetic interaction:GO:1903692 methionine import across plasma membrane [PMID:8893857]" /experiment="EXISTENCE:mutant phenotype:GO:0015191 L-methionine transmembrane transporter activity [PMID:8893857]" /experiment="EXISTENCE:mutant phenotype:GO:1903692 methionine import across plasma membrane [PMID:8893857]" /note="Low affinity methionine permease; similar to Mup1p" /db_xref="GeneID:856349" /db_xref="SGD:S000001028" ORIGIN 1 mepllfnsgk anpsqdvfid vevgdittky gstntgsfss mdtveaqaik aetarfmevp 61 qgrhlgvfst vvlfvsrimg sgifavpsvi llntggnkli yfaiwvfsaa iafaglylfl 121 efgswipksg grknflersf erprllisvv fscysvltgy altgsivfgk yvlsafgvtd 181 dswskyvsis fiifavlihg vsvrhgvfiq nalgglklim ivlmcfagly tlffykstgq 241 vawdlpvtqv ekdsllsvss iatafissff cfsgwdtvht vtseiknpvk tlkvsgplsl 301 iicfvcytmm nvaylkvlty eeivsagplv gsvlftklfg prvggkfiaf siaisaasni 361 lvviysisrv nqeifkegyl pfsihmsknw pfdaplpsis lcgfitiawi lilpkegesf 421 nylvsmdgyg nqfflllvai glfiwrfkhk nevpeirast fgvlaiitls lymlmapffa 481 dpslnrvgfl ppyqimsllv ivacfffwlv kfvllpkffh ykllpkityl hdglivtewv 541 kkpclc // LOCUS NP_011828 1592 aa linear PLN 30-JUN-2025 DEFINITION putative ATP-binding cassette multidrug transporter VMR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011828 VERSION NP_011828.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179115.1 REFERENCE 1 (residues 1 to 1592) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1592) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1592) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1592) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06650. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1592 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1592 /product="putative ATP-binding cassette multidrug transporter VMR1" /calculated_mol_wt="180796" Region 212..1575 /region_name="MRP_assoc_pro" /note="multi drug resistance-associated protein (MRP); TIGR00957" /db_xref="CDD:188098" CDS 1..1592 /gene="VMR1" /locus_tag="YHL035C" /coded_by="NM_001179115.1:1..4779" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20846144|PMID:23658021]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:genetic interaction:GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane [PMID:20846144]" /experiment="EXISTENCE:mutant phenotype:GO:0010038 response to metal ion [PMID:20846144]" /experiment="EXISTENCE:mutant phenotype:GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane [PMID:20846144]" /note="Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication" /db_xref="GeneID:856350" /db_xref="SGD:S000001027" ORIGIN 1 mgtdpliirn ngsfwevddf trlgrtqlls yylplaiias igifalcrsg lsryvrsaec 61 dlvneylfga qeerkednsi erllrnsntq anyvnvkkqg rilklrhfdi ttidvkqida 121 knhggltfsr pstsdhlrks seivlmslqi iglsflrvtk inieltnrdv ttlllfwlil 181 lslsilrvyk rstnlwaicf tahttiwist wipirsvyig niddvpsqif yifefvitst 241 lqpikltspi kdnssiiyvr ddhtspsreh issilscitw switnfiwea qkntiklkdi 301 wglsmedysi filkgftrrn khinnltlal fesfktylli gmlwvlvnsi vnllptilmk 361 rfleivdnpn rssscmnlaw lyiigmficr ltlaicnsqg qfvsdkiclr irailigeiy 421 akglrrrlft spktssdsds isanlgtiin lisidsfkvs elanylyvtv qavimiivvv 481 gllfnflgvs afagisiilv mfplnfllan llgkfqkqtl kctdqriskl neclqniriv 541 kyfawernii neiksirqke lrsllkkslv wsvtsflwfv tptlvtgvtf aictfvqhed 601 lnaplafttl slftllktpl dqlsnmlsfi nqskvslkri sdflrmddte kynqltispd 661 knkiefknat ltwnendsdm nafklcglni kfqigklnli lgstgsgksa lllgllgeln 721 lisgsiivps lepkhdlipd cegltnsfay csqsawllnd tvknniifdn fynedrynkv 781 idacglkrdl eilpagdlte igekgitlsg gqkqrislar avyssakhvl lddclsavds 841 htavwiyenc itgplmknrt cilvthnvsl tlrnahfaiv lengkvknqg titelqskgl 901 fkekyvqlss rdsineknan rlkaprknds qkiepvteni nfdanfvndg qlieeeeksn 961 gaispdvykw ylkffggfka ltalfalyit aqilfisqsw wirhwvndtn vrinapgfam 1021 dtlplkgmtd ssknkhnafy yltvyfligi iqamlggfkt mmtflsgmra srkifnnlld 1081 lvlhaqirff dvtpvgrimn rfskdiegvd qelipylevt ifcliqcasi iflitvitpr 1141 fltvavivfv lyffvgkwyl tasrelkrld sitkspifqh fsetlvgvct irafgderrf 1201 ilenmnkidq nnraffylsv tvkwfsfrvd migafivlas gsfillnian idsglagisl 1261 tyailftdga lwlvrlystf emnmnsverl keyssieqen ylghdegril llnepswpkd 1321 geieienlsl ryapnlppvi rnvsfkvdpq skigivgrtg agkstiital frllepitgc 1381 ikidgqdisk idlvtlrrsi tiipqdpilf agtiksnvdp ydeydekkif kalsqvnlis 1441 shefeevlns eerfnsthnk flnlhteiae gglnlsqger qllfiarsll repkiillde 1501 atssidydsd hliqgiirse fnkstiltia hrlrsvidyd riivmdagev keydrpsell 1561 kdergifysm crdsgglell kqiakqsskm mk // LOCUS NP_011829 294 aa linear PLN 30-JUN-2025 DEFINITION Sbp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011829 VERSION NP_011829.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179114.1 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 294) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06651. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..294 /product="Sbp1p" /calculated_mol_wt="32859" Region 39..113 /region_name="RRM_1" /note="RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain); pfam00076" /db_xref="CDD:425453" Region 187..269 /region_name="RRM" /note="RNA recognition motif; smart00360" /db_xref="CDD:214636" CDS 1..294 /gene="SBP1" /locus_tag="YHL034C" /gene_synonym="SSB1; SSBR1" /coded_by="NM_001179114.1:1..885" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:16782896|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:2823109|PMID:2121740]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16782896]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0031370 eukaryotic initiation factor 4G binding [PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0035617 stress granule disassembly [PMID:35440550]" /experiment="EXISTENCE:direct assay:GO:0045947 negative regulation of translational initiation [PMID:28986506|PMID:39617253]" /experiment="EXISTENCE:direct assay:GO:0048027 mRNA 5'-UTR binding [PMID:28986506|PMID:39617253]" /experiment="EXISTENCE:mutant phenotype:GO:0032055 negative regulation of translation in response to stress [PMID:16782896]" /experiment="EXISTENCE:mutant phenotype:GO:0045947 negative regulation of translational initiation [PMID:28986506|PMID:39617253]" /note="mRNA-binding translational repressor and P-body disassembly factor; binds to the 5'UTR of mRNAs and inhibits cap-dependent and independent translational initiation; involved in mRNA binding under glucose starvation stress; associates with snR10 and snR11; HMT1-dependent arginine monomethylation modulates translational repression, mRNA decay and stress granule localization during glucose starvation; contains an intrinsically disordered RGG motif; localizes to P bodies and stress granules" /db_xref="GeneID:856351" /db_xref="SGD:S000001026" ORIGIN 1 msaeieeatn avnnlsinds eqqprapthk tvidpedtif ignvahecte ddlkqlfvee 61 fgdevsveip ikehtdghip askhalvkfp tkidfdnike nydtkvvkdr eihikrartp 121 gqmqrggfrg rggfrgrggf rggfrggyrg gfrgrgnfrg rggarggfng qkrekipldq 181 merskdtlyi nnvpfkatke evaeffgtda dsislpmrkm rdqhtgrift sdsanrgmaf 241 vtfsgenvdi eakaeefkgk vfgdreltvd vavirpende eeieqetgse ekqe // LOCUS NP_011830 256 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL8 RPL8A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011830 VERSION NP_011830.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179113.1 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 256) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06652. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..256 /product="60S ribosomal protein eL8 RPL8A" /calculated_mol_wt="27994" Region 2..251 /region_name="SNU13" /note="U4/U6.U5 small nuclear ribonucleoprotein SNU13; cl42391" /db_xref="CDD:455736" Site order(137,140..141,144,159,161..162,164..165,168) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:411046" CDS 1..256 /gene="RPL8A" /locus_tag="YHL033C" /gene_synonym="MAK7" /coded_by="NM_001179113.1:1..771" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22893726]" /note="Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8A has paralog RPL8B from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog" /db_xref="GeneID:856352" /db_xref="SGD:S000001025" ORIGIN 1 mapgkkvapa pfgakstksn ktrnplthst pknfgigqav qpkrnlsryv kwpeyvrvqr 61 qkkilsirlk vpptiaqfqy tldrntaaet fklfnkyrpe taaekkerlt keaaavaegk 121 skqdaspkpy avkyglnhvv alienkkakl vliandvdpi elvvflpalc kkmgvpyaiv 181 kgkarlgtlv nqktsavaal tevraedeaa laklvstida nfadkydevk khwgggilgn 241 kaqakmdkra knsdsa // LOCUS NP_011831 709 aa linear PLN 30-JUN-2025 DEFINITION glycerol kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011831 VERSION NP_011831.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179112.1 REFERENCE 1 (residues 1 to 709) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 709) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 709) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 709) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06653. Method: conceptual translation. FEATURES Location/Qualifiers source 1..709 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..709 /product="glycerol kinase" /EC_number="2.7.1.30" /calculated_mol_wt="79694" Region 47..690 /region_name="ASKHA_NBD_FGGY_GK1-3-like" /note="nucleotide-binding domain (NBD) of metazoan glycerol kinase 1-3 (GK1-3) and similar proteins; cd07792" /db_xref="CDD:466802" CDS 1..709 /gene="GUT1" /locus_tag="YHL032C" /coded_by="NM_001179112.1:1..2130" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397]" /experiment="EXISTENCE:mutant phenotype:GO:0004370 glycerol kinase activity [PMID:8358828]" /experiment="EXISTENCE:mutant phenotype:GO:0006071 glycerol metabolic process [PMID:8358828]" /note="Glycerol kinase; converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p" /db_xref="GeneID:856353" /db_xref="SGD:S000001024" ORIGIN 1 mfpslfrlvv fskryifrss qrlytslkqe qsrmskimed lrsdyvplia sidvgttssr 61 cilfnrwgqd vskhqieyst saskgkigvs glrrpstapa retpnagdik tsgkpifsae 121 gyaiqetkfl kieeldldfh neptlkfpkp gwvechpqkl lvnvvqclas sllslqtins 181 ervanglppy kvicmgianm rettilwsrr tgkpivnygi vwndtrtiki vrdkwqntsv 241 drqlqlrqkt glpllstyfs csklrwfldn eplctkayee ndlmfgtvdt wliyqltkqk 301 afvsdvtnas rtgfmnlstl kydnellefw gidknlihmp eivsssqyyg dfgipdwime 361 klhdspktvl rdlvkrnlpi qgclgdqsas mvgqlaykpg aakctygtgc fllyntgtkk 421 lisqhgaltt lafwfphlqe yggqkpelsk phfalegsva vagavvqwlr dnlrlidkse 481 dvgpiastvp dsggvvfvpa fsglfapywd pdaratimgm sqfttashia raavegvcfq 541 arailkamss dafgegskdr dfleeisdvt yeksplsvla vdggmsrsne vmqiqadilg 601 pcvkvrrspt aectalgaai aanmafkdvn erplwkdlhd vkkwvfyngm ekneqispea 661 hpnlkifrse sddaerrkhw kywevavers kgwlkdiege heqvlenfq // LOCUS NP_011832 223 aa linear PLN 30-JUN-2025 DEFINITION Gos1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011832 VERSION NP_011832.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179111.1 REFERENCE 1 (residues 1 to 223) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 223) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 223) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 223) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06654. Method: conceptual translation. FEATURES Location/Qualifiers source 1..223 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..223 /product="Gos1p" /calculated_mol_wt="25264" Region 136..201 /region_name="V-SNARE_C" /note="Snare region anchored in the vesicle membrane C-terminus; pfam12352" /db_xref="CDD:289148" CDS 1..223 /gene="GOS1" /locus_tag="YHL031C" /coded_by="NM_001179111.1:1..672" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11959998]" /experiment="EXISTENCE:direct assay:GO:0005797 Golgi medial cisterna [PMID:16699523]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11959998]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11959998]" /experiment="EXISTENCE:mutant phenotype:GO:0048193 Golgi vesicle transport [PMID:9755865]" /note="v-SNARE protein involved in Golgi transport; homolog of the mammalian protein GOS-28/GS28" /db_xref="GeneID:856354" /db_xref="SGD:S000001023" ORIGIN 1 mssqpsfvti rgkaisletq tesllskyst faqttsseqt gqekkidkql egilgqrqdv 61 idsltqicds npaisaskls qlhrhkeilq dhwksfrnir ssiqqernrl nllfsvkndi 121 ansttdapap igdadeyiqn etrridqsnn vvdrlisqaw etrsqfhsqs nvlntannkv 181 lqtlqripgv nqlimkintr rkknafvlat ittlcilflf ftw // LOCUS NP_011833 1868 aa linear PLN 30-JUN-2025 DEFINITION Ecm29p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011833 VERSION NP_011833.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179110.1 REFERENCE 1 (residues 1 to 1868) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1868) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1868) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1868) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06655. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1868 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1868 /product="Ecm29p" /calculated_mol_wt="210301" Region 14..537 /region_name="Ecm29" /note="Proteasome stabilizer; pfam13001" /db_xref="CDD:463769" Region 1507..1535 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1548..1578 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1587..1616 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..1868 /gene="ECM29" /locus_tag="YHL030W" /coded_by="NM_001179110.1:1..5607" /experiment="EXISTENCE:direct assay:GO:0000502 proteasome complex [PMID:12408819]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:20620957|PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043248 proteasome assembly [PMID:20620957]" /experiment="EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:20620957]" /experiment="EXISTENCE:mutant phenotype:GO:0042030 ATPase inhibitor activity [PMID:23995839]" /note="Scaffold protein; assists in association of proteasome core particle with regulatory particle; inhibitor of proteasome in vivo and in vitro; inhibits proteasomal ATPase activity; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress" /db_xref="GeneID:856355" /db_xref="SGD:S000001022" ORIGIN 1 msissdeake kqlvekaelr laiadspqkf etnlqtflpp lllklaspha svrtavfsal 61 knlisrintl pqvqlpvral ivqakepnla aqqdstnvrl yslllaskgi drlslqdrqq 121 llplvvsnis cltgtvaarm fhillklile wvapqesshe qeefvqflql dndgfsflmr 181 qftrffllvp skqvqvsqqp lsrgytcpgl sltdvaffty dagvtfnkeq lnkfkkaifq 241 fvcrgmaatq tieqsprmie lmeflcvvst dstnlsddaa qfmkrfpmpy eneefitflq 301 tlyigntang rppvkailqe kilsilnrsh fattkaecis licsiglhss eyklrsltls 361 firhvaklny knlnpasssp sstdfstciv slirnnlhae gwpklqlgpq tpafntailq 421 rqlqyetlgd ilkrdfelvs dlsyieflfe slkndlpqfr ssiqesllsl vghlsilpqq 481 sklklknllr knlsideqqr ednndavnsi malkfvsikf tnaafpfhdp earlfniwgt 541 vrtnrfdiie esfkglqpfw frvnnasint satvktsdll gshlsetefp pfreflqvli 601 dqldseaasi trkslnnavr fskqclisna iygkktmviq dedwsvridk alelddtvvs 661 rvnemvqgmn ddifiryltl lsneftatns kgeqiaifpy qdpifgsvll tllnfvsnnv 721 lrrleilvpd lyhlvimkfq slsdndlavc atiigiista iadsthvkri tkiaqsqtma 781 etyvasyvvp rlylkdqtnh iesdsilnll niltthlshp gtnkdmilkl vcqvtkfgll 841 lqvsaqerkd flkkvmdtiq dklindvtai qtwsylslys tdlensslfq eklletnvsk 901 qndflfsvge slsvvagkws skylikqidi pnfnveimqq kfpatnvtti ldeifsgcds 961 tkpslrkasc iwllsyiqyl ghlpevsskc ndihlrfmrf ladrdefiqd saarglslvy 1021 eiggsdlkes mvkgllksft estagsasts atgisgsvse etelfepgvl ntgdgsisty 1081 kdilnlasev gdpalvykfm slakssalws srkgiafglg aimsksslee lllkdqqtak 1141 klipklyryr fdpfqavsrs mtdiwntlip essltislyf ndildellcg mankewrvre 1201 astsallqli qsqpqekfse kmlkiwtmaf rtmddikdsv revgtkfttv lakilarsid 1261 vekgvnptks keildnilpf lwgphglnsd aeevrnfalt tlidlvkhsp gaikpftpkl 1321 iydfitlfss iepqvinyla lnaanynida nvidtqrkng vtnsplfqti eklinnsddc 1381 mmeeiinvvi kasrksvglp skvasslvii ilvkrysiem kpysgkllkv cltmfedrne 1441 svniafaism gylfkvsald kcikysekli tkyfeptste nnkkvvgtai dsilnyakse 1501 fdnvasvfmp lifiacnded kdletlynki wteasssgag tvklylpeil nvlcvniksn 1561 dfsirktcak sviqlcggin dsipypqivk lfdisreals grswdgkehi vaalvsltek 1621 fsqtvadnnd lqesinhvmy tevsrksmky vkkilplyar yinvnpqeet itfliekake 1681 mirllgsesd dsegsikqts destikrikp nteitqkssk enieneeyvi nllkvsvdic 1741 nnsksrypmn llefiideia ylfhndriih twrtqlaase igisivgrfs tissadfiqn 1801 vgrlwdqtfp incnketien vklqmikfgg liiqkipslq nnieenlrll nsidstsrie 1861 lelknigl // LOCUS NP_011834 679 aa linear PLN 30-JUN-2025 DEFINITION Oca5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011834 VERSION NP_011834.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179109.1 REFERENCE 1 (residues 1 to 679) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 679) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 679) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 679) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06656. Method: conceptual translation. FEATURES Location/Qualifiers source 1..679 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..679 /product="Oca5p" /calculated_mol_wt="77626" Region 48..>215 /region_name="TBC" /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164" /db_xref="CDD:214540" CDS 1..679 /gene="OCA5" /locus_tag="YHL029C" /coded_by="NM_001179109.1:1..2040" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [PMID:36758548]" /experiment="EXISTENCE:mutant phenotype:GO:0071543 diphosphoinositol polyphosphate metabolic process [PMID:36758548]" /note="Inositol pyrophosphatase that catalyzes the conversion of 5-InsP7 to InsP6; controls the balance between glycolysis and respiration; localizes to the cytoplasm; required for replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural host" /db_xref="GeneID:856356" /db_xref="SGD:S000001021" ORIGIN 1 mhdkkspman shylknlkqq frnknliett ihlvkcndhd slaflartyg vppqlrhvvw 61 pillkyhpmc ispnitsnti swdpitndfi lndpflkska ptdkqdksdd enilpydies 121 iilhdlkkyf hsrsnpagss snanttniat ptpvsssdas tissmevlsp sldyefqiie 181 tlknaivkfl lkwskifkye sglawialgl aewypiypye tmspfneths fyevedyvvl 241 sgrkhallst nngnngnsns ssnntnnnnt nitsgmhnls intntslhns pyishtlsyl 301 ykeyplpfel rsklptkpif sfsalferla lvilhcpdti lahkqlknds nasssskans 361 nfntnyfpii sggdlsfqtq vffkvfssil pelyqpltee sslqpsssrn swiywwlkcs 421 gakalqrqdr grvwdlllgw rpkpnmdtin fflnyndkkm dhlyhdtpqc dneqywmkdw 481 ialynndpfw fpdldsmalg skkfpydysv fkelilrnry ggtqskaqkd ntvpspgsds 541 ndkselklpf ssidphmqli fifiailqfn efkllefeea eiseflnnvp lltkfddssy 601 rklyentess itslpssptt stmaslqsss nssahisnyh mlievgndak ashcfddlln 661 magdiwrkwl wreleessl // LOCUS NP_011835 605 aa linear PLN 30-JUN-2025 DEFINITION Wsc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011835 VERSION NP_011835.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179108.1 REFERENCE 1 (residues 1 to 605) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 605) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 605) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 605) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06657. Method: conceptual translation. FEATURES Location/Qualifiers source 1..605 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..605 /product="Wsc4p" /calculated_mol_wt="63677" Region 25..109 /region_name="WSC" /note="present in yeast cell wall integrity and stress response component proteins; smart00321" /db_xref="CDD:214616" CDS 1..605 /gene="WSC4" /locus_tag="YHL028W" /gene_synonym="YFW1; YHC8" /coded_by="NM_001179108.1:1..1818" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10196219]" /experiment="EXISTENCE:genetic interaction:GO:0009408 response to heat [PMID:11589572]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:10196219]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:10196219]" /experiment="EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:10196219]" /note="Endoplasmic reticulum (ER) membrane protein; involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3" /db_xref="GeneID:856357" /db_xref="SGD:S000001020" ORIGIN 1 mqtsmvsakv siwlvcsvic sslvratqsv cssqntattd gvrnqfqsng wcsnncaghq 61 faivqgfmcw csdsepstqt svgdcsgtcp gygyedcgna dkdlfgyiyl gqtplssvqs 121 vetstessvy vssssitsss stsivdttti sptltststt plttaststt pstditsalp 181 tttstklsts iptsttssts tttstsssts ttvsvtssts tttsttsstl iststsssss 241 stptttssap iststtssts tststtspts ssaptsssnt tptsttfttt spstapsstt 301 vtytsttasp itstitsvnl qtslkysvit vtsvhtmdtn iseitsrylt mkkvitqiys 361 stlgatptsa vattsasvgg ritnnnnsnt tnsntptnks tekkgywdsp gkiaatfvvv 421 gvvclviici liylihhyrt rparkaqdfe neyqskfyqs kypnevtttt lhtpspssns 481 tfstprliyt dekgqimses psprqstysl tagsppndps tlaspfhdpi lprrtstflh 541 spiqkqhekm esnvtlgedt vlvdqrldps kmlntlandd atnhstisls dnvdysrrvl 601 rlmne // LOCUS NP_011836 625 aa linear PLN 30-JUN-2025 DEFINITION alkaline-responsive transcriptional regulator RIM101 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011836 VERSION NP_011836.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179107.1 REFERENCE 1 (residues 1 to 625) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 625) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 625) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 625) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06658. Method: conceptual translation. FEATURES Location/Qualifiers source 1..625 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..625 /product="alkaline-responsive transcriptional regulator RIM101" /calculated_mol_wt="68101" Region 41..571 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 151..171 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(155,157,159,161..162,165..166,170,191,193,197..198, 201..202,205,219,221,223,225..226,229..230,233) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 184..206 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 214..234 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..625 /gene="RIM101" /locus_tag="YHL027W" /gene_synonym="RIM1" /coded_by="NM_001179107.1:1..1878" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12509465]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:16024810]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20382759]" /experiment="EXISTENCE:genetic interaction:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:16024810]" /experiment="EXISTENCE:genetic interaction:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]" /experiment="EXISTENCE:genetic interaction:GO:0010973 positive regulation of division septum assembly [PMID:19633265]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:16024810]" /experiment="EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:8417990]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8417990]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:8367297]" /experiment="EXISTENCE:mutant phenotype:GO:0071454 cellular response to anoxia [PMID:20402793]" /experiment="EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:11050096]" /note="Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression; involved in cell wall assembly; plays role in lager yeast flocculation under brewing conditions; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC" /db_xref="GeneID:856358" /db_xref="SGD:S000001019" ORIGIN 1 mvpledllnk engtaapqhs resivengtd vsnvtkkdgl pspnlskrss dcskrprirc 61 tteaiglngq edermspgst sssclpyhst shlntppydl lgasavsptt ssssdsssss 121 plaqahnpag ddddadndgd seditlyckw dncgmifnqp ellynhlchd hvgrkshknl 181 qlnchwgdct tktekrdhit shlrvhvplk pfgcstcskk fkrpqdlkkh lkihlesggi 241 lkrkrgpkwg skrtskknks casdavsscs asvpsaiags fkshstspqi lpplpvgisq 301 hlpsqqqqra islnqlcsde lsqykpvysp qlsarlqtil pplyynngst vsqgansrsm 361 nvyedgcsnk tianatqfft klsrnmtnny ilqqsggste sssssgripv aqtsyvqppn 421 apsyqsvqgg ssisatanta tyvpvrlaky ptgpsltehl pplhsntagg vfnrqsqyam 481 phypsvraap sysssgcsil pplqskipml psrrtmaggt slkpnwefsl nqksctndii 541 msklaieevd deseieddfv emlgivniik dyllccvmed lddeesedkd eenaflqesl 601 eklslqnqmg tnsvriltky pkilv // LOCUS NP_011837 315 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL026C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011837 VERSION NP_011837.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179106.1 REFERENCE 1 (residues 1 to 315) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 315) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 315) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 315) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06659. On Nov 30, 2005 this sequence version replaced NP_011837.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..315 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..315 /product="uncharacterized protein" /calculated_mol_wt="35586" Region 169..263 /region_name="DUF2456" /note="Protein of unknown function (DUF2456); pfam10445" /db_xref="CDD:402189" CDS 1..315 /locus_tag="YHL026C" /coded_by="NM_001179106.1:1..948" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; transcriptionally regulated by Upc2p via an upstream sterol response element; SWAT-GFP fusion protein localizes to the cell periphery, while mCherry fusion localizes to both the cell periphery and vacuole; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)" /db_xref="GeneID:856359" /db_xref="SGD:S000001018" ORIGIN 1 mkssepapat ptgfrnsiwf iifylfviqa lgsaiisggi efaiayamyh srvdlitlwa 61 fphtisgdca lslfiqvglt waseeilvgf ddykrpvfrl nkwitkpspl ktesneeipp 121 pkkrfivdyf eskdnvvakq ntlyhkhnwl fgylevnrgi ipkgkeatlk gfltsqfihd 181 stqskfmnfi ewfvqkfirs milaiamfiv iwpvtmgila gighkvgshd yyfndyplpq 241 vmkliyavvi afvctpvaii vivlrnqfhe elyyeglang tlqqdqevcs tgnrssgstd 301 qdisttkqqs qeava // LOCUS NP_011838 332 aa linear PLN 30-JUN-2025 DEFINITION Snf6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011838 VERSION NP_011838.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179105.1 REFERENCE 1 (residues 1 to 332) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 332) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 332) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 332) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06660. Method: conceptual translation. FEATURES Location/Qualifiers source 1..332 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..332 /product="Snf6p" /calculated_mol_wt="37476" Region 70..261 /region_name="SNF6" /note="transcription regulatory protein SNF6 domain family; cd22571" /db_xref="CDD:439338" Site order(74,77,80..81,83..88,92..93,95..99,101,103..104, 106..108,110..112,114..116,118..138,141,144..145,148..149, 152,164..170,173,176,186..187,191,196..209,216..217, 229..230) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:439338" CDS 1..332 /gene="SNF6" /locus_tag="YHL025W" /coded_by="NM_001179105.1:1..999" /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:23437238]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2188093|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:18644858|PMID:8159677|PMID:8127913|PMID:8016655]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:1459453]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1901413]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:23437238]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:17013386]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:17013386]" /experiment="EXISTENCE:mutant phenotype:GO:0016514 SWI/SNF complex [PMID:8159677]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:23437238]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1339306]" /experiment="EXISTENCE:physical interaction:GO:0006289 nucleotide-excision repair [PMID:17013386]" /note="Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p; relocates to the cytosol under hypoxic conditions" /db_xref="GeneID:856360" /db_xref="SGD:S000001017" ORIGIN 1 mgvikkkrsh hgkasrqqyy sgvqvggvgs mgainnnips ltsfaeenny qygysgssag 61 mngrsltyaq qqlnkqrqdf ervrlrpeql sniihdesdt isfrsnllkn fissndafnm 121 lslttvpcdr ieksrlfsek tirylmqkqh emktqaaelq ekpltplkyt kliaaaedgs 181 rstkdmidav feqdshlryq pdgvvvhrdd palvgklrgd lreapadywt hayrdvlaqy 241 heakerirqk evtageaqde aslqqqqqqd lqqqqqvvtt vasqsphata tekepvpavv 301 ddplenmfgd ysnepfntnf ddefgdldav ff // LOCUS NP_011839 713 aa linear PLN 30-JUN-2025 DEFINITION Rim4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011839 VERSION NP_011839.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179104.1 REFERENCE 1 (residues 1 to 713) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 713) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 713) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 713) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06661. Method: conceptual translation. FEATURES Location/Qualifiers source 1..713 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..713 /product="Rim4p" /calculated_mol_wt="79978" Region 91..176 /region_name="RRM1_RIM4_like" /note="RNA recognition motif 1 (RRM1) found in yeast meiotic activator RIM4 and similar proteins; cd12453" /db_xref="CDD:409887" Region 176..242 /region_name="RRM_SF" /note="RNA recognition motif (RRM) superfamily; cd00590" /db_xref="CDD:409669" Region 300..>378 /region_name="SF-CC1" /note="splicing factor, CC1-like family; TIGR01622" /db_xref="CDD:273721" Region 343..420 /region_name="RRM2_RIM4_like" /note="RNA recognition motif 2 (RRM2) found in yeast meiotic activator RIM4 and similar proteins; cd12454" /db_xref="CDD:409888" Region 615..>669 /region_name="YppG" /note="YppG-like protein; pfam14179" /db_xref="CDD:372950" CDS 1..713 /gene="RIM4" /locus_tag="YHL024W" /coded_by="NM_001179104.1:1..2142" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:10806425]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:11713679]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:11713679]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:10806425]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:11713679]" /note="Putative RNA-binding protein; involved in regulation of early and middle sporulation genes; forms amyloid-like aggregates under starvation that are active in translational repression" /db_xref="GeneID:856361" /db_xref="SGD:S000001016" ORIGIN 1 mkteistads lrdppsnglk adselvired idqflpsevs slgsdhqndg edsdtdsdnf 61 lqdpeddvde estgrgtvtt tststesrgr psscifvasl aaalsddelc lsvtenfkky 121 gdlarvkvlr dnanrpyafv qynndhdakh aliraqgtll ngrrlrcepa kvnrtlylkn 181 qqsidfneis qicekfggle qivpdrtdnq ytrrytypis sanswfvqfv yrddairaya 241 nlrtdpnwii ewaqninvpk nynllhkskf ksskyhqnng iinndgsnnn dnnnsnnnnr 301 edsrrngdvi eeecghvhgs dseekltsdg iyddedkdse itidkrsifv gqldkettre 361 elnrrfsthg kiqdinlifk ptnifafiky eteeaaaaal esenhaifln ktmhvqykev 421 ggrhnrkfsg knggsnfnhh qffstrsgkt ftgpelnlap ppinmyrkms ggsqqesetm 481 mpympmgpmp mgppppnaas lsdfdmfpps ystfmkgmmp lrrksmpnsw sspssksvns 541 enesvnggde nselpseipe ssgrynaans fttynnssag nsnnnnnnnn snsnksqykk 601 ryarrssygy nevppkpyyf qpyyyhpmqy hmgpmgplhp sqgsagnhhp ymmvypmspp 661 ppsgldgsmi pppinvsqsh aanhgsthvh anefisndtg dinednkays ldy // LOCUS NP_011840 1146 aa linear PLN 30-JUN-2025 DEFINITION Npr3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011840 VERSION NP_011840.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179103.1 REFERENCE 1 (residues 1 to 1146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1146) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06662. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1146 /product="Npr3p" /calculated_mol_wt="129843" Region 400..966 /region_name="NPR3" /note="Nitrogen Permease regulator of amino acid transport activity 3; pfam03666" /db_xref="CDD:427435" CDS 1..1146 /gene="NPR3" /locus_tag="YHL023C" /gene_synonym="RMD11" /coded_by="NM_001179103.1:1..3441" /experiment="EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]" /experiment="EXISTENCE:direct assay:GO:1990130 GATOR1 complex [PMID:21900499]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:25046117]" /experiment="EXISTENCE:genetic interaction:GO:0010508 positive regulation of autophagy [PMID:25046117]" /experiment="EXISTENCE:genetic interaction:GO:0051058 negative regulation of small GTPase mediated signal transduction [PMID:23716719]" /experiment="EXISTENCE:genetic interaction:GO:1904262 negative regulation of TORC1 signaling [PMID:23716719|PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:24603354]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0034198 cellular response to amino acid starvation [PMID:19521502]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:18069899]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:25046117|PMID:23716719|PMID:19521502]" /experiment="EXISTENCE:mutant phenotype:GO:2000785 regulation of autophagosome assembly [PMID:21900499]" /note="Subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is a subcomplex of SEAC, a coatomer-related complex that associates dynamically with the vacuole; Npr3p may have a structural or regulatory role, supporting Iml1p function as a GAP for the Rag family GTPase Gtr1p, and leading to inhibition of TORC1 signaling in response to amino acid deprivation; SEACIT is required for non-nitrogen-starvation-induced autophagy; null mutant has meiotic defects; human NPRL3 homolog" /db_xref="GeneID:856362" /db_xref="SGD:S000001015" ORIGIN 1 mdeclpnscl lgvhlvisth sgpqivyhyp psntafltnn ptkhqhlygn hanlnkntst 61 nkeeklfnsg stktasqial nesaksynta itpsmtntnt nnvtlpptrs hantvgsqss 121 ipaatngvgy rktdiedtsr tfqyqetese tsssglsdse lstdyldiss dsfsisssls 181 ssslssspss sssssppqdg lsrtnssfqs tdsmsptspq mimendsisv aesyldsgtn 241 nksraaskrs qnffhklstk kstdskthsp vrklkskpsq stkkgnkllk ntsnetdgna 301 ftgscsissk kslsstgehn qelrnsslnd tpgqsphhyh hryhhyhkna atsqrnshtq 361 ydveeedmev samlqdgkis mneiffeeen fqdinkilef dndfvaefcs peremcntrf 421 eftvdnfcfl glpihvdsqg rwrkskhknk trskrssstt tnisrkksia skisslsent 481 lkkvnsgead tvydsnighe astdtpnlri ntdvsgnefe rekedlgknm nmfhvcfvmn 541 phlieynkri ddmyqfvvtr lslllryvqs ktsyissech iilkekervl khsktyqsir 601 gagnkgkyly qrilakssla raltecvdki qrneiaclei nddkvislqi piqnefekmp 661 nfklqpvlrg syltsilnmk fleksslrie sqnrqndqaq fsdtnnniyr fgnninstgh 721 cgaanvddgd dnesnyycdd nddllnyall lldepnniis sletfsyqdd igtiilkhlv 781 rniqpniplr syrylitdll dnpsslddlt tetnslessi lrscalhlmy wrharivipl 841 sskytyivsp lapiqgytid dykstsqndg nvkkmddren nksgsdrvpl iyqnsmlfrs 901 kfpslpslpi flsllstdkp qaysniipsr ehkpvylnal awliqygyvt qlltfinirv 961 dkhikmavde dlekegfrkt ntarrpsmdy kktdkkldde dgqsrdanas eacsgknegm 1021 qsndnnkdvd ekdnendsrv ddrddneiai adeeeilhfe yddpemqhdy tiileperat 1081 aiekrwlyrc iygqpsdiqi lfnkllkyfn gkvpmelvii keeisrhdlk kllnaldkyl 1141 ieihhw // LOCUS NP_011841 398 aa linear PLN 30-JUN-2025 DEFINITION DNA topoisomerase (ATP-hydrolyzing) [Saccharomyces cerevisiae S288C]. ACCESSION NP_011841 VERSION NP_011841.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179102.1 REFERENCE 1 (residues 1 to 398) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 398) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 398) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 398) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06663. Method: conceptual translation. FEATURES Location/Qualifiers source 1..398 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..398 /product="DNA topoisomerase (ATP-hydrolyzing)" /EC_number="5.6.2.2" /calculated_mol_wt="45282" Region 106..168 /region_name="TP6A_N" /note="Type IIB DNA topoisomerase; pfam04406" /db_xref="CDD:461294" Region 227..397 /region_name="TOPRIM_TopoIIB_SPO" /note="topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI) and Saccharomyces...; cd00223" /db_xref="CDD:173774" Site order(233..234,288,290,296) /site_type="active" /db_xref="CDD:173774" Site order(233,288) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:173774" Site order(235,240,258,263,386,388,392) /site_type="active" /note="interdomain interaction site [active]" /db_xref="CDD:173774" CDS 1..398 /gene="SPO11" /locus_tag="YHL022C" /coded_by="NM_001179102.1:1..1197" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9039264]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23246437]" /experiment="EXISTENCE:direct assay:GO:0007127 meiosis I [PMID:9039264]" /experiment="EXISTENCE:direct assay:GO:0035861 site of double-strand break [PMID:23246437]" /experiment="EXISTENCE:direct assay:GO:0045027 DNA end binding [PMID:9039264]" /experiment="EXISTENCE:genetic interaction:GO:0042138 meiotic DNA double-strand break formation [PMID:2190690]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:8207053]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:2687110]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:2190690]" /note="Meiosis-specific protein required for meiotic recombination; makes DNA double-strand breaks (DSB) during meiotic recombination, homolog pairing, and synaptonemal complex formation; role in meiotic DSB formation involves a topo-II-like transesterase mechanism; forms monotetrameric complex; covalently linked to DSBs through a 5'-phosphodiester bond between a catalytic tyrosine (Y135) and the DSB 5'- end; sequence similarity to a topo VI subunit from archaea, fission yeast rec12 and human SPO11" /db_xref="GeneID:856364" /db_xref="SGD:S000001014" ORIGIN 1 maleglrkky ktrqelvkal tpkrrsihln snghsngtpc snadvlahik hflslaansl 61 eqhqqpisiv fqnkkkkgdt sspdihttld fplngphlct hqfklkrcai llnllkvvme 121 klplgknttv rdifysnvel fqrqanvvqw ldvirfnfkl sprkslniip aqkglvyspf 181 pidiydnilt cenepkmqkq tifpgkpcli pffqddavik lgttsmcniv ivekeavftk 241 lvnnyhklst ntmlitgkgf pdfltrlflk kleqycskli sdcsiftdad pygisialny 301 thsnernayi ctmanykgir itqvlaqnne vhnksiqlls lnqrdyslak nliasltans 361 wdiatsplkn viiecqreif fqkkaemnei darifeyk // LOCUS NP_011842 465 aa linear PLN 30-JUN-2025 DEFINITION Aim17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011842 VERSION NP_011842.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179101.1 REFERENCE 1 (residues 1 to 465) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 465) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 465) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 465) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06664. Method: conceptual translation. FEATURES Location/Qualifiers source 1..465 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..465 /product="Aim17p" /calculated_mol_wt="53004" Region 128..448 /region_name="CAS_like" /note="Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; cd00250" /db_xref="CDD:238154" Site order(213..214,249,251,256,311,442,444) /site_type="other" /note="substrate binding pocket [chemical binding]" /db_xref="CDD:238154" Site order(246,248,274,428,438) /site_type="active" /db_xref="CDD:238154" Site order(246,248,428) /site_type="other" /note="iron coordination sites [ion binding]" /db_xref="CDD:238154" CDS 1..465 /gene="AIM17" /locus_tag="YHL021C" /gene_synonym="FMP12" /coded_by="NM_001179101.1:1..1398" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:19300474]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss" /db_xref="GeneID:856365" /db_xref="SGD:S000001013" ORIGIN 1 mlrsnlcrgs rilarltttp rtytsaataa aanrghiikt yfnrdsttit fsmeesskpv 61 svcfnnvflr dashsaklvt tgelyhnekl tapqdiqise dgkslvvkwk dgghhqfplq 121 ffidykgssf vspatrkqes ryrpqlwnkr ilkdnvkdll svsynefidp kddsklfqtl 181 vnlqkfgiaf isgtpsssse gltiqkicer igpirstvhg egtfdvnasq atsvnahyan 241 kdlplhtdlp flenvpgfqi lqslpatege dpntrpmnyf vdafyatrnv resdfeayea 301 lqivpvnyiy engdkryyqs kpliehhdin edntllgnye alikcinysp pyqapftfgi 361 ydkpsdlnnn ldlnlittpa klterflfks firglnlfes hindfnnqfr lqlpenccvi 421 fnnrrilhan sltssnqqwl kgcyfdsdtf ksklkfleek fphdk // LOCUS NP_011843 404 aa linear PLN 30-JUN-2025 DEFINITION transcriptional regulator OPI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011843 VERSION NP_011843.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179100.1 REFERENCE 1 (residues 1 to 404) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 404) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 404) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 404) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06665. Method: conceptual translation. FEATURES Location/Qualifiers source 1..404 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..404 /product="transcriptional regulator OPI1" /calculated_mol_wt="45934" Region <131..361 /region_name="Opi1" /note="Transcription factor Opi1; pfam08618" /db_xref="CDD:370005" CDS 1..404 /gene="OPI1" /locus_tag="YHL020C" /coded_by="NM_001179100.1:1..1215" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:27663510|PMID:15455074|PMID:15192221]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15192221]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15455074]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15192221]" /experiment="EXISTENCE:direct assay:GO:0016036 cellular response to phosphate starvation [PMID:27743455]" /experiment="EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:15455074]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:27480805]" /experiment="EXISTENCE:direct assay:GO:0071072 negative regulation of phospholipid biosynthetic process [PMID:27743455]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:1985968]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:1985968]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16582425]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12871953]" /experiment="EXISTENCE:physical interaction:GO:0003714 transcription corepressor activity [PMID:11454208]" /note="Transcriptional regulator of a variety of genes; critical sensor of genotoxic stress; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance; null exhibits disrupted mitochondrial metabolism and low cardiolipin content, strongly correlated with overproduction of inositol; binds to phosphatidic acid" /db_xref="GeneID:856366" /db_xref="SGD:S000001012" ORIGIN 1 msenqrlgls eeeveaaevl gvlkqscrqk sqpsedvsqa dkmpasesst tplnildrvs 61 nkiisnvvtf ydeintnkrp lksigrlldd dddehddydy nddefftnkr qklsraiakg 121 kdnlkeykln msieskkrlv tclhllklan kqlsdkiscl qdlvekeqvh plhkqdgnar 181 tttgagedet ssdeddddee ffdaseqvna seqsivvkme vvgtvkkvys liskftansl 241 peparsqvre sllnlptnwf dsvhstslph hasfhyance eqkveqqqqq qqqqqqqqll 301 qqqllqqqqq krnkdgddsa spsssvtang kvlilakesl emvrnvmgvv dstlgkaeew 361 vkqkqevkem irerflqqqq qyrqqqqkdg nyvkpsqdnv dskd // LOCUS NP_011844 605 aa linear PLN 30-JUN-2025 DEFINITION Apm2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011844 VERSION NP_011844.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179099.1 REFERENCE 1 (residues 1 to 605) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 605) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 605) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 605) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06666. Method: conceptual translation. FEATURES Location/Qualifiers source 1..605 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..605 /product="Apm2p" /calculated_mol_wt="69859" Region 3..138 /region_name="AP_Mu_N" /note="AP complex subunit mu N-terminal domain; cd14828" /db_xref="CDD:341432" Site order(18,21,42..43,51,53,55,67..68,73,75..77,80,84, 112..113,116..117,119..121,123..126,135,137..138) /site_type="other" /note="AP beta interface [polypeptide binding]" /db_xref="CDD:341432" Region 256..603 /region_name="AP-1_Mu1_Cterm" /note="C-terminal domain of medium Mu1 subunit in clathrin-associated adaptor protein (AP) complex AP-1; cd09250" /db_xref="CDD:271158" Site order(267,288,290,292..293,303,313,328,331,375,382,384,400, 414,416,422,427,454,459,462..463,472,478..479,500,560..562, 565,574..577,587..591,596,598..599) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:271158" Site order(273..275,303,426,562,564,589..592,594) /site_type="signal peptide" /note="signal peptide binding site [polypeptide binding]" /db_xref="CDD:271158" CDS 1..605 /gene="APM2" /locus_tag="YHL019C" /coded_by="NM_001179099.1:1..1818" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:26658609]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:26658609]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:17003107]" /note="One of two alternative Mu1-like medium subunits of the clathrin-associated AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; homologous to the medium chain of mammalian clathrin-associated protein complex" /db_xref="GeneID:856367" /db_xref="SGD:S000001011" ORIGIN 1 mssslfilde nleplvskni ralpnlssvl ssfkqcyhdg sppilsqndw ffihlkrdfl 61 hfvsvihttd kpnidlmtil afleqfyhll qkyfeievlt knvildnill vlelidecid 121 fgivqvtdps iikdyirvkv nvprvtvdne ewspgeesss ssgsdsdsey sntnkrkdkk 181 kkrkkkkgtk gksvgksklk simvnnkenr ginvvetvke tlrnkndtgk eaandelpnd 241 gndlyingdi aktiimpisw rtkgihyakn effldvierv qylmdfekgv irknlihgei 301 vcrcylsgmp klkisinkil nrdpqfmsns sfhqcvslds intiekdeek nsdddaglqa 361 atdareiefi ppdgefvlcq yelkrhvkda pmvrlkdfei kpklkkfkiq ivtkiqtnfk 421 ptnstsklnv ripltkvfqe ykidlskqir fkanigkvvf nlsddfllwe iqtmkghreh 481 stnkssqyns deddpntcas mvaefplfnq eeydrlqeem ktsmnppplr tgprleelyr 541 qvhdqqtshv tprdklvnid feipyctcsg lkveylkvee pqlqyqsfpw vryktvsdee 601 yayiv // LOCUS NP_011845 120 aa linear PLN 30-JUN-2025 DEFINITION 4a-hydroxytetrahydrobiopterin dehydratase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011845 VERSION NP_011845.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179098.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 120) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06667. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..120 /product="4a-hydroxytetrahydrobiopterin dehydratase" /EC_number="4.2.1.96" /calculated_mol_wt="13895" Region 13..113 /region_name="Pterin_4a" /note="Pterin 4 alpha carbinolamine dehydratase; pfam01329" /db_xref="CDD:460161" CDS 1..120 /gene="MCO14" /locus_tag="YHL018W" /coded_by="NM_001179098.1:1..363" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Putative 4a-hydroxytetrahydrobiopterin dehydratase; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:856368" /db_xref="SGD:S000001010" ORIGIN 1 mhnkivrias saltggklle klkpltrwev qwdpnktkcl gitrevtfkd yettwafltr 61 vsmrshlwgh hplihtsytw vklelhthdi dpkdgahsql sdidvrmakr idsyidemtt // LOCUS NP_011846 532 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL017W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011846 VERSION NP_011846.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179097.1 REFERENCE 1 (residues 1 to 532) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 532) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 532) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 532) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06668. Method: conceptual translation. FEATURES Location/Qualifiers source 1..532 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..532 /product="uncharacterized protein" /calculated_mol_wt="61075" Region 152..444 /region_name="Lung_7-TM_R" /note="Lung seven transmembrane receptor; pfam06814" /db_xref="CDD:369089" CDS 1..532 /locus_tag="YHL017W" /coded_by="NM_001179097.1:1..1599" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication" /db_xref="GeneID:856369" /db_xref="SGD:S000001009" ORIGIN 1 mdrtwllltw llllcgvvqg nqesinqkyh dvcsgmyske dfngkvdpyi sftleelsla 61 dedddgegvs vavfdfqdye higvrlpnge iqyicddyal dlglcedsse gqfiiqetai 121 dpftskehkl tsqiltftqq elgtndkvys inktgyycvt tssfissssk fkatvnfrna 181 ygqldaseay kmpiyaflav ayavctlvys wlcwkhrhel lplqryilvf cifltadtif 241 vwmyyiienq kgnssvalhv ymvfisifsa gkmtftllla llislgygiv ypkldrtllr 301 rcqifaiftf avcvaflvqk ysqnseslsn lilitaiplv lclfafyylt lssmnktmty 361 lreqnqvvkl nmyrkliilc yislfilflg llvstfayvg mdtvdmieqy wkteflitdt 421 wpsfvyflvf vifaffwrpt stsyllacsh qlptdmenvs efdlddinsl sdealpnrep 481 rndyqehdhn mdidlasdfe evpsvnantn anndvlfdvd ydrdakndrs tt // LOCUS NP_011847 735 aa linear PLN 30-JUN-2025 DEFINITION Dur3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011847 VERSION NP_011847.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179096.1 REFERENCE 1 (residues 1 to 735) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 735) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 735) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 735) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 735) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 735) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 735) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06669. Method: conceptual translation. FEATURES Location/Qualifiers source 1..735 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..735 /product="Dur3p" /calculated_mol_wt="80486" Region 14..517 /region_name="SLC5sbd_DUR3" /note="Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; cd11476" /db_xref="CDD:271370" Site order(66,69,363,366..367) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271370" CDS 1..735 /gene="DUR3" /locus_tag="YHL016C" /coded_by="NM_001179096.1:1..2208" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015489 putrescine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015606 spermidine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015847 putrescine transport [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015848 spermidine transport [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:8335627]" /experiment="EXISTENCE:mutant phenotype:GO:0015204 urea transmembrane transporter activity [PMID:8335627]" /experiment="EXISTENCE:mutant phenotype:GO:0015489 putrescine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0015606 spermidine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0015840 urea transport [PMID:8335627]" /experiment="EXISTENCE:mutant phenotype:GO:0015847 putrescine transport [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0015848 spermidine transport [PMID:17218313]" /note="Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway" /db_xref="GeneID:856370" /db_xref="SGD:S000001008" ORIGIN 1 mgefkpplpq gagyaivlgl gavfagmmvl ttyllkryqk eiitaeeftt agrsvktglv 61 aaavvsswiw cstlltsstk eyadgifggy ayaagacfqi iafailaikt kqmapnahty 121 lelvrtrygk ighgcylfya iatnilvtsm lltsgsavfs dltgmntias cfllpvgvvv 181 ytlfggikat fltdymhtcv iiiivlvfaf kvyatsdvlg spgkvydlvr eaakrhpvdg 241 nyqgeymtmt sksagillii nlignfgtvf ldngywnkai saspaaslka yaigglawfa 301 vpslisltmg laclavetsp nfptypdplt sfqansglvl paaaiaimgk ggavasllmi 361 fmavtsamsa eliavssvft ydiyreyidp rasgkkliyt shvaciffgl amsgfsvgly 421 yggismgyiy emmgiiissa vlpvvltlcs kdmnlvaavv spilgtglai mswlvctksl 481 ykeltvdttf mdypmltgnl vallspaifi piltyvfkpq nfdwekmkdi trvdetaelv 541 qadpdiqlyd aeandkeqee etnslvsdse kndvrvnnek liepnlgvvi snaifqeddt 601 qlqneldeeq relarglkia yflcvffala flvvwpmpmy gskyifskkf ftgwvvvmii 661 wlffsafavc iyplwegrhg iyttlrglyw dlsgqtyklr ewqnsnpqdl hvvtsqisar 721 ahrqsshfgq vdeii // LOCUS NP_878085 27 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL015W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878085 VERSION NP_878085.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184649.1 REFERENCE 1 (residues 1 to 27) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 27) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 27) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 27) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 27) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 27) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 27) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06670. Method: conceptual translation. FEATURES Location/Qualifiers source 1..27 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..27 /product="uncharacterized protein" /calculated_mol_wt="3069" CDS 1..27 /locus_tag="YHL015W-A" /coded_by="NM_001184649.1:1..84" /note="hypothetical protein" /db_xref="GeneID:1466525" /db_xref="SGD:S000028828" ORIGIN 1 mtafaslrep lvlanlkikv hiyrmkr // LOCUS NP_011848 121 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS10 RPS20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011848 VERSION NP_011848.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179095.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 121) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06671. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..121 /product="40S ribosomal protein uS10 RPS20" /calculated_mol_wt="13776" Region 23..118 /region_name="rpsJ" /note="30S ribosomal protein S10; Reviewed; cl00314" /db_xref="CDD:469716" CDS 1..121 /gene="RPS20" /locus_tag="YHL015W" /gene_synonym="URP2" /coded_by="NM_001179095.1:1..366" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10" /db_xref="GeneID:856371" /db_xref="SGD:S000001007" ORIGIN 1 msdfqkekve eqeqqqqqii kiritltstk vkqlenvssn ivknaeqhnl vkkgpvrlpt 61 kvlkistrkt pngegsktwe tyemrihkry idleapvqiv kritqitiep gvdvevvvas 121 n // LOCUS NP_011849 405 aa linear PLN 30-JUN-2025 DEFINITION Ylf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011849 VERSION NP_011849.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179094.1 REFERENCE 1 (residues 1 to 405) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 405) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 405) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 405) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06672. Method: conceptual translation. FEATURES Location/Qualifiers source 1..405 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..405 /product="Ylf2p" /calculated_mol_wt="45584" Region 16..400 /region_name="TIGR00092" /note="GTP-binding protein YchF" /db_xref="CDD:129200" CDS 1..405 /gene="YLF2" /locus_tag="YHL014C" /gene_synonym="YLF1" /coded_by="NM_001179094.1:1..1218" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239]" /note="hypothetical protein; has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:856372" /db_xref="SGD:S000001006" ORIGIN 1 mnigggkfll grisnnptsg ivglanvgks tffqaitnsk lgnpanypfa tidaecakvn 61 ipsvplsnll riyqsakcvp gtltiydiag ltrgasqghg lgnkflndir hvegifqvvr 121 gflkedithi egnvdpvrdl svvqdelilk dleflenire rlskkmrmvs knskehqemk 181 ietelldale ehlfngkkir hfkdhwnlde vkilnkhnfl tskptlilln vspqdyvrne 241 nkfvrniiew inefspgdkf llfsaefesq lmeckgiase yfdkikedtn vsdqqlvsai 301 pqiilemrkl lnlisfftcg pqevhqwnir egttaqeaag vihsdlretf isadvikydd 361 lkkmepplne sllkskglik ragkqyimqd ndialfkaag gkikk // LOCUS NP_011850 307 aa linear PLN 30-JUN-2025 DEFINITION deubiquitinase OTU2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011850 VERSION NP_011850.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179093.1 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 307) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06673. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..307 /product="deubiquitinase OTU2" /calculated_mol_wt="35982" Region 1..306 /region_name="COG5539" /note="Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]" /db_xref="CDD:227826" CDS 1..307 /gene="OTU2" /locus_tag="YHL013C" /coded_by="NM_001179093.1:1..924" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856373" /db_xref="SGD:S000001005" ORIGIN 1 mtgmesgenl enmedilarh rkenkdlqnk itgmkkqatk skrkevnskc ldlqdklktk 61 qeneirdwki annevfdaeq edevtpekll eqlsisrdek eqqnvpvqqq qqgqtkkrrn 121 rqkerlakrd aaiakmkeea aleaskqpdl kkmeqesidq lcelkklkqf diqpdghclf 181 asildqlklr hdpkkldqdm dvmklrwlsc nyvqehrddf ipylfdeetm kmkdideytk 241 emehtaqwgg eieilalshv fdcpisilms grpiqvynec gknpelklvy ykhsyalgeh 301 ynslhds // LOCUS NP_011851 493 aa linear PLN 30-JUN-2025 DEFINITION UTP--glucose-1-phosphate uridylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011851 VERSION NP_011851.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179092.1 REFERENCE 1 (residues 1 to 493) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 493) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 493) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 493) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06674. Method: conceptual translation. FEATURES Location/Qualifiers source 1..493 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..493 /product="UTP--glucose-1-phosphate uridylyltransferase" /EC_number="2.7.7.9" /calculated_mol_wt="55869" Region 46..455 /region_name="UDPGP" /note="UTP--glucose-1-phosphate uridylyltransferase; pfam01704" /db_xref="CDD:460300" CDS 1..493 /locus_tag="YHL012W" /coded_by="NM_001179092.1:1..1482" /note="Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication" /db_xref="GeneID:856374" /db_xref="SGD:S000001004" ORIGIN 1 mtvfsgvnki efegtfegig kdvvmsqmir alqkhfpsir dknyefslfl hifqryvlen 61 tsithdlvcd kirlpiidev velddiknyg llegkllskl ailkltgkan piigkesplf 121 evkngmssld vivrqtqnln vrynsdvpli fmtsletesq vsnfleehys sskvrwktvv 181 qssfpqidkd rllpidlqin shendfwypc gtgnltdtly fsgeldklia qgkeilfvsn 241 vdnlgatgdl nilnfiinek ieylvevver tanvsntgvl atykgklrsv yynclsnesa 301 stcrivntnn iwidlkklkv liesnslnlp ihsseskith kneeieclqf ktqlvdciaf 361 fpnsrvlkvs rdrflplrtc kdlfllkstl ydldsngtfn lyplkfgllp sidlgdefat 421 yetfkigvpd ipnilelehl tvmgnvffgr nitlkgtvii icdendvitv pdgsilenvt 481 iwhksqledm ngy // LOCUS NP_011852 320 aa linear PLN 30-JUN-2025 DEFINITION ribose phosphate diphosphokinase subunit PRS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011852 VERSION NP_011852.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179091.1 REFERENCE 1 (residues 1 to 320) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 320) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 320) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 320) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06675. Method: conceptual translation. FEATURES Location/Qualifiers source 1..320 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..320 /product="ribose phosphate diphosphokinase subunit PRS3" /EC_number="2.7.6.1" /calculated_mol_wt="34993" Region 4..315 /region_name="PrsA" /note="Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; COG0462" /db_xref="CDD:440230" CDS 1..320 /gene="PRS3" /locus_tag="YHL011C" /coded_by="NM_001179091.1:1..963" /experiment="EXISTENCE:direct assay:GO:0002189 ribose phosphate diphosphokinase complex [PMID:15280369]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004749 ribose phosphate diphosphokinase activity [PMID:15280369]" /experiment="EXISTENCE:genetic interaction:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:15280369]" /experiment="EXISTENCE:mutant phenotype:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:10212224]" /note="5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes" /db_xref="GeneID:856375" /db_xref="SGD:S000001003" ORIGIN 1 mptnsiklla pdvhrglael vakrlglqlt ssklkrdptg evsfsigesv rdqdifiitq 61 igsgvvndrv lelliminas ktasarrita iipnfpyarq drkdksrapi taklmadmlt 121 tagcdhvitm dlhasqiqgf fdvpvdnlya epsvvryike nvnymdsiii spdaggakra 181 atladrldln falihkerar anevsrmvlv gdvtdkicii vddmadtcgt lakaaeille 241 nraksviaiv thgvlsgrai eninnskldr vvctntvpfe ekikkcpkla vidissvlae 301 sirrlhnges isylfknypl // LOCUS NP_011853 585 aa linear PLN 30-JUN-2025 DEFINITION Etp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011853 VERSION NP_011853.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179090.1 REFERENCE 1 (residues 1 to 585) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 585) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 585) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 585) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06676. Method: conceptual translation. FEATURES Location/Qualifiers source 1..585 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..585 /product="Etp1p" /calculated_mol_wt="67373" Region 114..201 /region_name="RRM_ETP1" /note="RNA recognition motif (RRM) found in yeast RING finger protein ETP1 and similar proteins; cd12717" /db_xref="CDD:410116" Region 238..281 /region_name="RING-H2_BRAP2" /note="RING finger, H2 subclass, found in BRCA1-associated protein (BRAP2) and similar proteins; cd16457" /db_xref="CDD:438121" Region 301..363 /region_name="zf-UBP" /note="Zn-finger in ubiquitin-hydrolases and other protein; pfam02148" /db_xref="CDD:460464" Region <409..>556 /region_name="Smc" /note="Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; COG1196" /db_xref="CDD:440809" CDS 1..585 /gene="ETP1" /locus_tag="YHL010C" /coded_by="NM_001179090.1:1..1758" /experiment="EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:9497340]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:16564012]" /experiment="EXISTENCE:mutant phenotype:GO:0045471 response to ethanol [PMID:19416103]" /note="hypothetical protein required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences" /db_xref="GeneID:856376" /db_xref="SGD:S000001002" ORIGIN 1 mdqfeyiitl efgnqnqves ayqifksipk klkaksigee siksnnqdwq dwrvcdleid 61 mitdfknqts keeesdlits qylghgiirl fklsnanntl nekeiltipg ddtmicilfv 121 ptyftvhdll hfyigddivn kqvsnfrilr nqqkgmgfnf tvlikfrnal daknfkeefn 181 gksfsrmdpe tchvisvkei vfqkklfqrp aanedfpyll tdpftvkkkk elvkvelptc 241 pvclermdse ttglvtipcq htfhcqclnk wknsrcpvcr hsslrlsres llkqagdsah 301 catcgstdnl wiclicgnvg cgrynskhai khyeetlhcf amdirtqrvw dyagdnyvhr 361 lvqnevdgkl vevggsgddd nndignsdel qnvvygnrsk ngeksnsnkk dgelaanflr 421 hreyhleyvq vlisqlesqr eyyelklqek dqtasdssnv eslkksmedl klqfqvtqke 481 wqkremaqks kleedmlvie glqanldhls kkqeqleren kaleeskqdl eeqvkdlmfy 541 ldsqekfkda desvkegtil iqqphgaaqa skskkkrnkn kkagk // LOCUS NP_011854 330 aa linear PLN 30-JUN-2025 DEFINITION Yap3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011854 VERSION NP_011854.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179089.1 REFERENCE 1 (residues 1 to 330) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 330) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 330) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 330) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06677. Method: conceptual translation. FEATURES Location/Qualifiers source 1..330 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..330 /product="Yap3p" /calculated_mol_wt="37824" Region 145..207 /region_name="bZIP_YAP" /note="Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain; cd14688" /db_xref="CDD:269836" Site order(145..146,150..151,153..155,157..158,161..162, 164..165) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269836" Region 149..207 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269836" Site order(168..169,172..173,175..176,179..180,182..183,186, 189..190,193..194,197,200..201,203..204) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269836" CDS 1..330 /gene="YAP3" /locus_tag="YHL009C" /coded_by="NM_001179089.1:1..993" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9372930]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:9372930]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9372930]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Basic leucine zipper (bZIP) transcription factor" /db_xref="GeneID:856377" /db_xref="SGD:S000001001" ORIGIN 1 mtpsnmddnt sgfmkfinpq cqeedccirn slfqedskci kqqpdllseq tapfpiledq 61 cpalnldrsn ndlllqnnis fpkgsdlqai qltpisgdys tyvmadnnnn dndsysntny 121 fsknngisps srspsvahne nvpddskakk kaqnraaqka frerkearmk elqdkllese 181 rnrqsllkei eelrkantei naenrlllrs gnenfskdie ddtnykysfp tkdefftsmv 241 lesklnhkgk yslkdneimk rntqytdeag rhvltvpatw eylyklseer dfdvtyvmsk 301 lqgqecchth gpayprslid flveeatlne // LOCUS NP_058134 413 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058134 VERSION NP_058134.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184403.1 REFERENCE 1 (residues 1 to 413) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 413) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 413) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 413) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06679. Method: conceptual translation. FEATURES Location/Qualifiers source 1..413 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..413 /product="gag protein" /calculated_mol_wt="48083" CDS 1..413 /locus_tag="YHL009W-A" /coded_by="NM_001184403.1:1..1242" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:856379" /db_xref="SGD:S000007371" ORIGIN 1 matpvrdetr nviddnisar iqskvktndt vrqtpsslrk vsikdeqvkq yqrnlnrfkt 61 ilnglkaeee klsetddiqm laekllklge tidkvenriv dlvekiqlle tnennnilhe 121 hidatgtyyl fdtltstnkr fypkdcvfdy rtnnvenipi llnnfkkfik kyqfddvfen 181 diieidpren eilckiikeg lgesldimnt nttdifriid glknkyrslh grdvrirawe 241 kvlvdttcrn sallmnklqk lvlmekwifs kccqdcpnlk dylqeaimgt lheslrnsvk 301 qrlyniphnv ginheeflin tvietvidls piaddqiens cmycksvfhc sinckkkpnr 361 elrpdstnfs ktyylqgaqr qqqlkssakr tkvleqdtkk vkqsvqqqkt gny // LOCUS NP_058133 1802 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058133 VERSION NP_058133.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184404.2 REFERENCE 1 (residues 1 to 1802) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1802) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1802) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1802) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06678. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1802 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1802 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="207840" Region 623..723 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1322..1532 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1640..1777 /region_name="RNase_H_like" /note="Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; cl14782" /db_xref="CDD:449355" Site order(1644..1647,1682..1683,1686,1720,1760,1773) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:259998" CDS 1..1802 /locus_tag="YHL009W-B" /coded_by="join(NM_001184404.2:1..1086, NM_001184404.2:1088..5410)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:856380" /db_xref="SGD:S000007372" ORIGIN 1 matpvrdetr nviddnisar iqskvktndt vrqtpsslrk vsikdeqvkq yqrnlnrfkt 61 ilnglkaeee klsetddiqm laekllklge tidkvenriv dlvekiqlle tnennnilhe 121 hidatgtyyl fdtltstnkr fypkdcvfdy rtnnvenipi llnnfkkfik kyqfddvfen 181 diieidpren eilckiikeg lgesldimnt nttdifriid glknkyrslh grdvrirawe 241 kvlvdttcrn sallmnklqk lvlmekwifs kccqdcpnlk dylqeaimgt lheslrnsvk 301 qrlyniphnv ginheeflin tvietvidls piaddqiens cmycksvfhc sinckkkpnr 361 elgltrpisq kpiiykvhrd nnnlspvqne qkswnktqkk snkvynskkl viidtgsgvn 421 itndktllhn yedsnrstrf fgigknssvs vkgygyikik nghnntdnkc lltyyvpeee 481 stiiscydla kktkmvlsrk ytrlgnkiik iktkivngvi hvkmnelier psddskinai 541 kptsspgfkl nkrsitleda hkrmghtgiq qiensikhnh yeesldlike pnefwcqtck 601 iskatkrnhy tgsmnnhstd hepgsswcmd ifgpvsssna dtkrymlimv dnntrycmts 661 thfnknaeti laqirkniqy vetqfdrkvr einsdrgtef tndqieeyfi skgihhilts 721 tqdhaangra eryirtivtd attllrqsnl rvkfweyavt satnirncle hkstgklplk 781 aisrqpvtvr lmsflpfgek giiwnhnhkk lkpsglpsii lckdpnsygy kffipsknki 841 vtsdnytipn ytmdgrvrnt qniykshqfs shndneedqi etvtnlceal enyeddnkpi 901 trledlftee elsqidsnak ypspsnnleg dldyvfsdve esgdydvese lsttntsist 961 dknkilsnkd fnselastei siseidkkgl intshidedk ydekvhrips iiqeklvgsk 1021 ntikindenr isdrirskni gsilntglsr cvditdesit nkdesmhnak peliqeqfnk 1081 tnhetsfpke gsigtnvkfr ntdneislkt gdtslpiktl esinnhhsnd ystnkvekfe 1141 kenhhpppie divdmsdqtd mesncqdgnn lkelkvtdkn vptdngtnvs prleqnieas 1201 gspvqtvnks aflnkefssl nmkrkrkrhd knnsltsyel erdkkrskrn rvklipdnme 1261 tvsaqkirai yyneaisknp dlkekheykq ayhkelqnlk dmkvfdvdvk ysrseipdnl 1321 ivptntiftk krngiykari vcrgdtqspd tysvittesl nhnhikiflm iannrnmfmk 1381 tldinhafly akleeeiyip hphdrrcvvk lnkalyglkq spkewndhlr qylngiglkd 1441 nsytpglyqt edknlmiavy vddcviaasn eqrldefink lksnfelkit gtliddvldt 1501 dilgmdlvyn krlgtidltl ksfinrmdkk yneelkkirk ssiphmstyk idpkkdvlqm 1561 seeefrqgvl klqqllgeln yvrhkcrydi nfavkkvarl vnyphervfy miykiiqylv 1621 rykdigihyd rdcnkdkkvi aitdasvgse ydaqsrigvi lwygmnifnv ysnkstnrcv 1681 ssteaelhai yegyadsetl kvtlkelgeg dnndivmitd skpaiqglnr syqqpkekft 1741 wikteiikek ikeksikllk itgkgniadl ltkpvsasdf krfiqvlknk itsqdilast 1801 dy // LOCUS NP_011855 627 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL008C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011855 VERSION NP_011855.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179088.1 REFERENCE 1 (residues 1 to 627) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 627) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 627) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 627) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06680. Method: conceptual translation. FEATURES Location/Qualifiers source 1..627 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..627 /product="uncharacterized protein" /calculated_mol_wt="69838" Region 24..263 /region_name="fnt" /note="formate/nitrite transporter; TIGR00790" /db_xref="CDD:273269" CDS 1..627 /locus_tag="YHL008C" /coded_by="NM_001179088.1:1..1884" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006821 chloride transport [PMID:18378800]" /experiment="EXISTENCE:mutant phenotype:GO:0140299 molecular sensor activity [PMID:18378800]" /experiment="EXISTENCE:mutant phenotype:GO:2001225 regulation of chloride transport [PMID:18378800]" /note="hypothetical protein; may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole" /db_xref="GeneID:856381" /db_xref="SGD:S000001000" ORIGIN 1 mvddsnyltp hetalavvat amkkarlqld tllinsilgg vlfssgsfll vavysedpdi 61 varnpgivnl itgvnfamgl fyvvmmgadl fnsnilffsv gvlrkavtiy dlmiswvvsw 121 lgniagslfv sylfghlsgi ssqklwiigs rqiieqkvsy sfvqtflkgi acnffvclai 181 ylqlmakpih vkfilmsfpi idfigigfth vvgdmsasfi amlnganvsv gkyiwkllip 241 aslgnivggl ffsavvpfyl hlvvverdrk rlslpeyear deqpelnmds rvvriqknec 301 dddatetged lenltekgfa siyntnhdns syftgrslns lrsipssvit sdnvtmesdl 361 gepvqfipks nsttrsphlg lphnlphnhs iksinrhrin krhslrsppg vfpvrgmgep 421 lerektieda tydpkenelf lrraethnsa yvknkkkedd nllrlvktee dreqkeyekn 481 ggynilenkp gtrlekiith laenvssrev tppilprttq dtfphnapas spaytddahs 541 lrkansttlg glfravskef hsskdaespd dllkkmaavg inrnaritan nvagivnlnk 601 edldsttrrq kitepknfyn rhtspql // LOCUS NP_011856 939 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase kinase kinase kinase STE20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011856 VERSION NP_011856.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179087.1 REFERENCE 1 (residues 1 to 939) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 939) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 939) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 939) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 939) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 939) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 939) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06681. Method: conceptual translation. FEATURES Location/Qualifiers source 1..939 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..939 /product="mitogen-activated protein kinase kinase kinase kinase STE20" /EC_number="2.7.11.1" /calculated_mol_wt="102231" Region 336..394 /region_name="PBD" /note="P21-Rho-binding domain; pfam00786" /db_xref="CDD:395634" Site order(337,340,343,345,348,365,369) /site_type="other" /note="GTPase interaction site [polypeptide binding]" /db_xref="CDD:238526" Region 619..872 /region_name="STKc_PAK" /note="Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; cd06614" /db_xref="CDD:270789" Site order(626..630,634,647,649,678,694..698,700..701,704,739, 741..744,746,756..757,760,773..777,779,806,815..817) /site_type="active" /db_xref="CDD:270789" Site order(626..630,634,647,649,678,694..698,700..701,704, 743..744,746,756..757) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270789" Site order(629..630,739,741..743,760,773..777,779,806,815..817) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270789" Site order(756..767,772..779) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270789" CDS 1..939 /gene="STE20" /locus_tag="YHL007C" /coded_by="NM_001179087.1:1..2820" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9003780]" /experiment="EXISTENCE:direct assay:GO:0000165 MAPK cascade [PMID:7608157]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15652479|PMID:19793923]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0008349 MAP kinase kinase kinase kinase activity [PMID:7608157]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9003780]" /experiment="EXISTENCE:direct assay:GO:0044025 histone H2BS14 kinase activity [PMID:15652479]" /experiment="EXISTENCE:direct assay:GO:0070301 cellular response to hydrogen peroxide [PMID:15652479]" /experiment="EXISTENCE:genetic interaction:GO:0000011 vacuole inheritance [PMID:19218422]" /experiment="EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:1464311]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:genetic interaction:GO:0007121 bipolar cellular bud site selection [PMID:10866679]" /experiment="EXISTENCE:genetic interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:10970855]" /experiment="EXISTENCE:genetic interaction:GO:0010629 negative regulation of gene expression [PMID:19793923]" /experiment="EXISTENCE:genetic interaction:GO:0034063 stress granule assembly [PMID:20513766]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:19218422]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:11452010]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:1464311]" /experiment="EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:8259520]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:8001818]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:12234925]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:10866679]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:8259520]" /experiment="EXISTENCE:mutant phenotype:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:10970855]" /experiment="EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:20513766]" /experiment="EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0043065 positive regulation of apoptotic process [PMID:15652479]" /experiment="EXISTENCE:mutant phenotype:GO:2000910 negative regulation of sterol import [PMID:19793923]" /experiment="EXISTENCE:physical interaction:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:9428767]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9428767]" /note="Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family" /db_xref="GeneID:856382" /db_xref="SGD:S000000999" ORIGIN 1 msndpsavse lpdkdsldng isndneramg gngdggdglr lprttgtlnv nalqkgtnaa 61 heaggyksmd paknaettnd ddnnvvsldd piqftrvsss svisgmsssm sphsnidetk 121 sleavtpnin tsnitpdhsa dntfstinas esdhqfndtl lsklsltdst etiennatvk 181 hqqpvasstv nsnksstdir ratpvstpvi skpsmtttpr qinsashsls npkhkqhkpk 241 vkpskpeaks kpvsvkksfp sknplknssp pkkqteksyy sssskkrksg snsgtlrmkd 301 vftsfvqnik rnsqddkras sssnnsssss ittalristp ynakhihhvg vdsktgeytg 361 lpeewekllt ssgiskreqq qnmqavmdiv kfyqdvtetn gedkmfktfn tttglpgspq 421 vstppansfn kfppstsdsh nygsrtgtpm snhvmsptln tdsssangkf ipsrpapkpp 481 ssasasapii kspvmnsaan vsplkqthap ttpnrtspnr ssisrnatlk keeqplppip 541 ptksktspii stahtpqqva qspkapaqet vttptskpaq arslskelne kkreererrk 601 kqlyaklnei csdgdpstky anlvkigqga sggvytayei gtnvsvaikq mnlekqpkke 661 liineilvmk gskhpnivnf idsyvlkgdl wvimeymegg sltdvvthci ltegqigavc 721 retlsglefl hskgvlhrdi ksdnillsme gdikltdfgf caqinelnlk rttmvgtpyw 781 mapevvsrke ygpkvdiwsl gimiiemieg eppylnetpl ralyliatng tpklkepenl 841 ssslkkfldw clcvepedra satellhdey iteiaeanss laplvklarl kkvaenmdad 901 edndddndne hinktnncdd nndsketvnl dvteddkqk // LOCUS NP_011857 150 aa linear PLN 30-JUN-2025 DEFINITION Shu1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011857 VERSION NP_011857.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179086.1 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 150) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06682. On Feb 2, 2004 this sequence version replaced NP_011857.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..150 /product="Shu1p" /calculated_mol_wt="16990" CDS 1..150 /gene="SHU1" /locus_tag="YHL006C" /coded_by="NM_001179086.1:1..453" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:21372173]" /experiment="EXISTENCE:direct assay:GO:0097196 Shu complex [PMID:23575680]" /experiment="EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:15654096]" /experiment="EXISTENCE:genetic interaction:GO:0043007 maintenance of rDNA [PMID:21372173]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:23575680]" /experiment="EXISTENCE:mutant phenotype:GO:0000730 DNA recombinase assembly [PMID:23575680]" /experiment="EXISTENCE:mutant phenotype:GO:0035861 site of double-strand break [PMID:23575680]" /experiment="EXISTENCE:physical interaction:GO:0097196 Shu complex [PMID:15654096]" /note="Component of Shu complex (aka PCSS complex); Shu complex also includes Psy3, Csm2, Shu2, and promotes error-free DNA repair, mediates inhibition of Srs2p function; essential for promoting the establishment of homolog bias during meiotic homologous recombination; promotes both crossover (CO) and non-crossover (NCO) pathways of meiotic recombination and formation of Rad51p filaments" /db_xref="GeneID:856383" /db_xref="SGD:S000000998" ORIGIN 1 mqfeerlqql vesdwsldqs spnvlvivlg dtarkyvelg glkehvttnt vaghvasrer 61 vsvvflgrvk ylymyltrmq aqangpqysn vlvyglwdlt atqdgpqqlr llslvlrqcl 121 slpskvefyp eppsssvpar llrfwdhiir // LOCUS NP_001335738 130 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHL005C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335738 VERSION NP_001335738.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348872.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 130) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80258. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..130 /product="uncharacterized protein" /calculated_mol_wt="15251" CDS 1..130 /locus_tag="YHL005C" /coded_by="NM_001348872.1:1..393" /note="hypothetical protein; conserved among S. cerevisiae strains; YHL005C is not an essential gene" /db_xref="GeneID:856385" /db_xref="SGD:S000000997" ORIGIN 1 mrkesfltfy fsnhlylcpa iirlssvctl artdyylpsn iavtydiqis slgftyridf 61 flalfsdpar pflteinrki gqyacvirer eqageysfhy slcininvyi lhihiyidry 121 iyayinaqvq // LOCUS NP_011859 394 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS2m MRP4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011859 VERSION NP_011859.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179084.1 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 394) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06683. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..394 /product="mitochondrial 37S ribosomal protein uS2m MRP4" /calculated_mol_wt="44021" Region 188..383 /region_name="Ribosomal_S2" /note="Ribosomal protein S2; pfam00318" /db_xref="CDD:459759" CDS 1..394 /gene="MRP4" /locus_tag="YHL004W" /gene_synonym="uS2m" /coded_by="NM_001179084.1:1..1185" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:856384" /db_xref="SGD:S000000996" ORIGIN 1 mqrhvfarnf rrlsllrnps ltkrfqssas gaantpnnnd evmllqqkll ydeirselks 61 lsqvpedeil pelkksleqd klsdkeqqle aelsdffrny allnklfdsk tldgqssttt 121 aaatptkpyp nlipsandkp yssqelflrq lnhsmrtakl gatiskvyyp hkdifypplp 181 enitveslms agvhlgqsts lwrsstqsyi ygeykgihii dlnqtlsylk raakvvegvs 241 esggiilflg trqgqkrgle eaakkthgyy vstrwipgtl tnsteisgiw ekqeidsndn 301 pteralspne tskqvkpdll vvlnptenrn alleaiksrv ptiaiidtds epslvtypip 361 gnddslrsvn fllgvlarag qrglqnrlar nnek // LOCUS NP_011860 411 aa linear PLN 30-JUN-2025 DEFINITION sphingosine N-acyltransferase LAG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011860 VERSION NP_011860.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179083.1 REFERENCE 1 (residues 1 to 411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 411) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06684. Method: conceptual translation. FEATURES Location/Qualifiers source 1..411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..411 /product="sphingosine N-acyltransferase LAG1" /EC_number="2.3.1.297" /calculated_mol_wt="48324" Region 8..411 /region_name="LAG1" /note="Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion]; COG5058" /db_xref="CDD:227391" CDS 1..411 /gene="LAG1" /locus_tag="YHL003C" /coded_by="NM_001179083.1:1..1236" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276|PMID:14562095|PMID:26928762|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0046513 ceramide biosynthetic process [PMID:15692566]" /experiment="EXISTENCE:direct assay:GO:0050291 sphingosine N-acyltransferase activity [PMID:15692566]" /experiment="EXISTENCE:direct assay:GO:0061576 acyl-CoA ceramide synthase complex [PMID:15692566]" /experiment="EXISTENCE:mutant phenotype:GO:0046513 ceramide biosynthetic process [PMID:11694577]" /experiment="EXISTENCE:mutant phenotype:GO:0050291 sphingosine N-acyltransferase activity [PMID:11694577|PMID:11387200]" /note="Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication" /db_xref="GeneID:856386" /db_xref="SGD:S000000995" ORIGIN 1 mtsatdksid rlvvnaktrr rnssvgkidl gdtvpgfaam pesaasknea kkrmkaltgd 61 skkdsdllwk vwfsyremny rhswltpffi lvcvysayfl sgnrtesnpl hmfvaisyqv 121 dgtdsyakgi kdlsfvffym ifftflrefl mdvvirpftv ylnvtsehrq krmleqmyai 181 fycgvsgpfg lyimyhsdlw lfktkpmyrt ypvitnpflf kifylgqaaf waqqacvlvl 241 qlekprkdyk elvfhhivtl lliwssyvfh ftkmglaiyi tmdvsdffls lsktlnylns 301 vftpfvfglf vffwiylrhv vnirilwsvl tefrhegnyv lnfatqqykc wislpivfvl 361 iaalqlvnly wlflilrily rliwqgiqkd ersdsdsdes aeneeskekc e // LOCUS NP_011861 452 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-0 subunit protein HSE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011861 VERSION NP_011861.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179082.1 REFERENCE 1 (residues 1 to 452) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 452) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 452) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 452) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06685. Method: conceptual translation. FEATURES Location/Qualifiers source 1..452 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..452 /product="ESCRT-0 subunit protein HSE1" /calculated_mol_wt="51030" Region 8..140 /region_name="VHS_HSE1" /note="VHS (Vps27/Hrs/STAM) domain of Class E vacuolar protein-sorting machinery protein HSE1; cd16978" /db_xref="CDD:340775" Site order(25..26,29,33,74..75) /site_type="other" /note="putative ubiquitin binding site [polypeptide binding]" /db_xref="CDD:340775" Region 221..273 /region_name="SH3_GRB2_like_C" /note="C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2 (GRB2) and related proteins; cd11805" /db_xref="CDD:212739" Site order(226,228,231..232,235,253..254,265,267,269..270) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212739" Region 290..374 /region_name="GAT_Hse1" /note="non-canonical GAT domain found in fungal class E vacuolar protein-sorting machinery protein Hse1 and similar proteins; cd21386" /db_xref="CDD:410591" Site order(292..293,295..296,299..300,302..303,306..307,310,319, 328,332,335,338,342,345..346,348..349,352..353,355..356, 358..359,362..363,365..366,369..370,372..373) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:410591" CDS 1..452 /gene="HSE1" /locus_tag="YHL002W" /coded_by="NM_001179082.1:1..1359" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:12055639]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:31740006]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12055639|PMID:20150893]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12055639]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:31740006]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12055639]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0006623 protein targeting to vacuole [PMID:12055639]" /experiment="EXISTENCE:physical interaction:GO:0033565 ESCRT-0 complex [PMID:12055639]" /note="Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes" /db_xref="GeneID:856387" /db_xref="SGD:S000000994" ORIGIN 1 msssaikirn allkatdpkl rsdnwqyild vcdlvkedpe dngqevmsli ekrleqqdan 61 vilrtlsltv slaencgsrl rqeissknft sllyaliesh svhitlkkav tdvvkqlsds 121 fkddpslram gdlydkikrk apylvqpnvp ekhnmstqad nsddeelqka lkmslfeyek 181 qkklqeqeke saevlpqqqq qhqqqnqapa hkipaqtvvr rvralydltt nepdelsfrk 241 gdvitvleqv yrdwwkgalr gnmgifplny vtpivepske eiekeknkea ivfsqkttid 301 qlhnslnaas ktgnsnevlq dphigdmygs vtplrpqvtr mlgkyakeke dmlslrqvla 361 naersynqlm draanahisp pvpgpalyag mthanntpvm ppqrqsyqsn eyspypsnlp 421 iqhptnsann tpqygydlgy svvsqpppgy eq // LOCUS NP_011862 138 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL14 RPL14B [Saccharomyces cerevisiae S288C]. ACCESSION NP_011862 VERSION NP_011862.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179081.1 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 138) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06686. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..138 /product="60S ribosomal protein eL14 RPL14B" /calculated_mol_wt="15022" Region 13..131 /region_name="eL14" /note="Vairimorpha necatrix ribosomal protein eL14 and similar proteins; cd23702" /db_xref="CDD:467915" Region 55..128 /region_name="Ribosomal_L14e" /note="Ribosomal protein L14; pfam01929" /db_xref="CDD:460388" CDS 1..138 /gene="RPL14B" /locus_tag="YHL001W" /coded_by="NM_001179081.1:1..417" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:29788267]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:29788267]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:29788267]" /note="Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856388" /db_xref="SGD:S000000993" ORIGIN 1 mstdsivkas nwrlvevgrv vlikkgqsag klaaiveiid qkkvlidgpk agvprqainl 61 gqvvltpltf alprgartat vskkwaaagv cekwaasswa kkiaqrerra altdferfqv 121 mvlrkqkryt vkkalaka // LOCUS NP_011863 437 aa linear PLN 30-JUN-2025 DEFINITION oxysterol-binding protein related protein OSH7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011863 VERSION NP_011863.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179131.1 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 437) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06687. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..437 /product="oxysterol-binding protein related protein OSH7" /calculated_mol_wt="49674" Region 53..393 /region_name="Oxysterol_BP" /note="Oxysterol-binding protein; pfam01237" /db_xref="CDD:460126" CDS 1..437 /gene="OSH7" /locus_tag="YHR001W" /coded_by="NM_001179131.1:1..1314" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16096648]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:29487131]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]" /experiment="EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:16585271]" /experiment="EXISTENCE:genetic interaction:GO:0016125 sterol metabolic process [PMID:16096648]" /experiment="EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:16096648]" /note="Oxysterol-binding phosphatidylserine transferase; part of family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; OSH7 has a paralog, OSH6, that arose from the whole genome duplication" /db_xref="GeneID:856389" /db_xref="SGD:S000001043" ORIGIN 1 malnklknip sltnsshssi ngiasnaans kpsgadtddi dendesgqsi llniisqlkp 61 gcdlsritlp tfilekksml eritnqlqfp dvlleahsnk dglqrfvkvv awylagwhig 121 pravkkplnp ilgehftayw dlpnkqqafy iaeqtshhpp esayfymipe snirvdgvvv 181 pkskflgnss aammegltvl qfldikdang kpekytlsqp nvyargilfg kmrielgdhm 241 vimgpkyqvd iefktkgfis gtydaiegti kdydgkeyyq isgkwndimy ikdlrekssk 301 ktvlfdthqh fplapkvrpl eeqgeyesrr lwkkvtdala vrdhevatee kfqienrqre 361 lakkraedgv efhsklfrra epgedldyyi ykhipegtdk heeqirsile tapilpgqtf 421 tekfsipayk khgiqkn // LOCUS NP_011864 77 aa linear PLN 30-JUN-2025 DEFINITION ubiquinol--cytochrome-c reductase subunit 10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011864 VERSION NP_011864.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181426.1 REFERENCE 1 (residues 1 to 77) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 77) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 77) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 77) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06688. Method: conceptual translation. FEATURES Location/Qualifiers source 1..77 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..77 /product="ubiquinol--cytochrome-c reductase subunit 10" /calculated_mol_wt="8462" Region 15..76 /region_name="QCR10" /note="Ubiquinol-cytochrome-c reductase complex subunit (QCR10); pfam09796" /db_xref="CDD:430833" CDS 1..77 /gene="QCR10" /locus_tag="YHR001W-A" /coded_by="NM_001181426.1:1..234" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:8175712]" /experiment="EXISTENCE:genetic interaction:GO:0009060 aerobic respiration [PMID:8175712]" /experiment="EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:8175712]" /experiment="EXISTENCE:mutant phenotype:GO:0008121 quinol-cytochrome-c reductase activity [PMID:8175712]" /note="Subunit of the ubiqunol-cytochrome c oxidoreductase complex; this complex comprises part of the mitochondrial respiratory chain; members include Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain" /db_xref="GeneID:856390" /db_xref="SGD:S000003529" ORIGIN 1 maytshlssk tglhfgrlsl rsltayapnl mlwggasmlg lfvftegwpk fqdtlykkip 61 llgptledht ppedkpn // LOCUS NP_011865 357 aa linear PLN 30-JUN-2025 DEFINITION coenzyme A transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_011865 VERSION NP_011865.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179132.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 357) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06689. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..357 /product="coenzyme A transporter" /calculated_mol_wt="40694" Region 32..127 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 38..329 /region_name="PTZ00169" /note="ADP/ATP transporter on adenylate translocase; Provisional" /db_xref="CDD:240302" CDS 1..357 /gene="LEU5" /locus_tag="YHR002W" /coded_by="NM_001179132.1:1..1074" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11158296]" /experiment="EXISTENCE:mutant phenotype:GO:0015228 coenzyme A transmembrane transporter activity [PMID:11158296]" /experiment="EXISTENCE:mutant phenotype:GO:0015880 coenzyme A transport [PMID:11158296]" /note="Mitochondrial carrier protein; involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein SLC25A16, which complements yeast null mutant; does not encode an isozyme of Leu4p, as first hypothesized" /db_xref="GeneID:856391" /db_xref="SGD:S000001044" ORIGIN 1 mtrdspdsnd sykhinkntt qktsfdrnsf dyivrsglag gisgscaktl iapldrikil 61 fqtsnphytk ytgsliglve aakhiwindg vrgffqghsa tllrifpyaa vkfvayeqir 121 ntlipskefe shwrrlvsgs laglcsvfit ypldlvrvrl ayetehkrvk lgriikkiyk 181 epasatlikn dyipnwfchw cnfyrgyvpt vlgmipyagv sffahdllhd vlkspffapy 241 svlelsedde lervqkkqrr plrtwaelis gglagmasqt aaypfeiirr rlqvsalspk 301 tmydhkfqsi seiahiifke rgvrgffvgl sigyikvtpm vacsffvyer mkwnfgi // LOCUS NP_011866 429 aa linear PLN 30-JUN-2025 DEFINITION tRNA threonylcarbamoyladenosine dehydratase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011866 VERSION NP_011866.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179133.1 REFERENCE 1 (residues 1 to 429) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 429) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 429) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 429) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06690. Method: conceptual translation. FEATURES Location/Qualifiers source 1..429 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..429 /product="tRNA threonylcarbamoyladenosine dehydratase" /calculated_mol_wt="48752" Region 64..298 /region_name="YgdL_like" /note="Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; cd00755" /db_xref="CDD:238384" Site order(81,83,85,105,107,116,129,175,181) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:238384" Site order(85,182,200..201,207) /site_type="other" /note="putative substrate interface [chemical binding]" /db_xref="CDD:238384" CDS 1..429 /gene="TCD1" /locus_tag="YHR003C" /coded_by="NM_001179133.1:1..1290" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0061503 tRNA threonylcarbamoyladenosine dehydratase [PMID:23242255]" /experiment="EXISTENCE:mutant phenotype:GO:0061504 cyclic threonylcarbamoyladenosine biosynthetic process [PMID:23242255]" /note="tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD1 has a paralog, TCD2, that arose from the whole genome duplication" /db_xref="GeneID:856392" /db_xref="SGD:S000001045" ORIGIN 1 manntwklia ttalisvfst qlaksvwkey klscaanknk tvsrprqydd hlfreqlarn 61 yaflgeegmr kikeqyiviv gagevgswvc tmlirsgcqk imiidpenis idslnthcca 121 vlsdigkpkv qclkehlski apwseikara kawtkenshd lifadgespt fivdcldnle 181 skvdlleyah hnkidvissm gvatksdptr vsindismte fdpisrcvrr klrkrgiatg 241 isvvfsneml dprrddilsp idcehraina vrdealrhlp elgtmpgifg lsiatwiltk 301 vsgypmkene vknrlkfyds iletfqkqma rlnenkerss llgleevgyi veemfrgksp 361 isgystklal tkweankeis ltnvvlmtke eqeihekril ldgekltavy seevldfier 421 lfkeeeyys // LOCUS NP_011867 446 aa linear PLN 30-JUN-2025 DEFINITION Nem1-Spo7 phosphatase catalytic subunit NEM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011867 VERSION NP_011867.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179134.1 REFERENCE 1 (residues 1 to 446) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 446) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 446) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 446) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06691. Method: conceptual translation. FEATURES Location/Qualifiers source 1..446 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..446 /product="Nem1-Spo7 phosphatase catalytic subunit NEM1" /EC_number="3.1.3.16" /calculated_mol_wt="50511" Region 252..431 /region_name="NIF" /note="NLI interacting factor-like phosphatase; pfam03031" /db_xref="CDD:397254" Site order(257..261,265..266,318..321,325,360,386..387,389..391) /site_type="active" /db_xref="CDD:319823" CDS 1..446 /gene="NEM1" /locus_tag="YHR004C" /coded_by="NM_001179134.1:1..1341" /experiment="EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:15889145|PMID:25359770]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:32349126]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:26275961]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9822591]" /experiment="EXISTENCE:genetic interaction:GO:0071072 negative regulation of phospholipid biosynthetic process [PMID:15889145]" /experiment="EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:9822591]" /experiment="EXISTENCE:mutant phenotype:GO:0046889 positive regulation of lipid biosynthetic process [PMID:32349126]" /experiment="EXISTENCE:mutant phenotype:GO:0071071 regulation of phospholipid biosynthetic process [PMID:30201607]" /experiment="EXISTENCE:mutant phenotype:GO:0140042 lipid droplet formation [PMID:32349126]" /experiment="EXISTENCE:physical interaction:GO:0071595 Nem1-Spo7 phosphatase complex [PMID:9822591]" /note="Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear/ER membrane association and activation of Pah1p, a phosphatidate phosphatase involved in the production of diacylglycerol DAG for lipid droplet biogenesis; regulates nuclear growth by controlling phospholipid biosynthesis; required for normal nuclear envelope morphology and sporulation; phosphatase activity of the Nem1p-Spo7p complex is inhibited by Ice2p; homolog of the human protein Dullard" /db_xref="GeneID:856393" /db_xref="SGD:S000001046" ORIGIN 1 mnalkyfsnh littkkqkki nvevtknqdl lgpskevsnk ytshsendcv sevdqqydhs 61 sshlkesdqn qerknsvpkk pkalrsilie kiasilwall lflpyyliik plmslwfvft 121 fplsvierrv khtdkrnrgs nasenelpvs ssnindssek tnpkncnlnt ipeaveddln 181 asdeiilqrd nvkgsllraq svksrprsys kselslsnhs ssntvfgtkr mgrflfpkkl 241 ipksvlntqk kkklvidlde tlihsasrst thsnssqghl vevkfglsgi rtlyfihkrp 301 ycdlfltkvs kwydliifta smkeyadpvi dwlessfpss fskryyrsdc vlrdgvgyik 361 dlsivkdsee ngkgssssld dviiidnspv syamnvdnai qvegwisdpt dtdllnllpf 421 leamrystdv rnilalkhge kafnin // LOCUS NP_011868 472 aa linear PLN 30-JUN-2025 DEFINITION guanine nucleotide-binding protein subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_011868 VERSION NP_011868.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179135.1 REFERENCE 1 (residues 1 to 472) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 472) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 472) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 472) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06692. Method: conceptual translation. FEATURES Location/Qualifiers source 1..472 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..472 /product="guanine nucleotide-binding protein subunit alpha" /calculated_mol_wt="53945" Region 42..466 /region_name="G-alpha" /note="Alpha subunit of G proteins (guanine nucleotide binding); cd00066" /db_xref="CDD:206639" Site order(48,53..55,300,319,322,388..389,391,443..444) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206639" Site 48..55 /site_type="other" /note="G1 box" /db_xref="CDD:206639" Site order(49..51,79,83,87,90,93..94,142,145,268,297,322,330, 334) /site_type="active" /note="GoLoco binding site [active]" /db_xref="CDD:206639" Site 295..303 /site_type="other" /note="Switch I region" /db_xref="CDD:206639" Site 300 /site_type="other" /note="G2 box" /db_xref="CDD:206639" Site order(301,303,305,316,318,322..324,326,329..330,332..335) /site_type="other" /note="beta - gamma complex interaction site [polypeptide binding]" /db_xref="CDD:206639" Site order(303,328,331..332,335) /site_type="other" /note="adenylyl cyclase interaction site [polypeptide binding]" /db_xref="CDD:206639" Site 319..322 /site_type="other" /note="G3 box" /db_xref="CDD:206639" Site 320..336 /site_type="other" /note="Switch II region" /db_xref="CDD:206639" Site 388..391 /site_type="other" /note="G4 box" /db_xref="CDD:206639" Site order(435..446,448..451) /site_type="active" /note="putative receptor binding site [active]" /db_xref="CDD:206639" Site 443..445 /site_type="other" /note="G5 box" /db_xref="CDD:206639" CDS 1..472 /gene="GPA1" /locus_tag="YHR005C" /gene_synonym="CDC70; DAC1; SCG1" /coded_by="NM_001179135.1:1..1419" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11394869]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:16839886]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005834 heterotrimeric G-protein complex [PMID:11394869]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8756677]" /experiment="EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:2107073]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:19386762]" /experiment="EXISTENCE:mutant phenotype:GO:0000743 nuclear migration involved in conjugation with cellular fusion [PMID:19386762]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3113739]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:1900495]" /experiment="EXISTENCE:mutant phenotype:GO:0005834 heterotrimeric G-protein complex [PMID:2105453]" /experiment="EXISTENCE:mutant phenotype:GO:0006109 regulation of carbohydrate metabolic process [PMID:34214075]" /experiment="EXISTENCE:physical interaction:GO:0005834 heterotrimeric G-protein complex [PMID:11394869]" /experiment="EXISTENCE:physical interaction:GO:0031681 G-protein beta-subunit binding [PMID:8417317]" /note="Subunit of G protein involved in pheromone response; GTP-binding alpha subunit of heterotrimeric G protein; negatively regulates mating pathway by sequestering G(beta)gamma and triggering an adaptive response; activates Vps34p at endosome; protein abundance increases in response to DNA replication stress; mutations in human homolog GNAS associated with McCune-Albright syndrome" /db_xref="GeneID:856394" /db_xref="SGD:S000001047" ORIGIN 1 mgctvstqti gdesdpflqn krandvieqs lqlekqrdkn eikllllgag esgkstvlkq 61 lkllhqggfs hqerlqyaqv iwadaiqsmk iliiqarklg iqldcddpin nkdlfackri 121 llkakaldyi nasvaggsdf lndyvlkyse ryetrrrvqs tgrakaafde dgnisnvksd 181 tdrdaetvtq nedadrnnss rinlqdickd lnqegddqmf vrktsreiqg qnrrnlihed 241 iakaikqlwn ndkgikqcfa rsnefqlegs aayyfdniek faspnyvctd edilkgrikt 301 tgitetefni gsskfkvlda ggqrserkkw ihcfegitav lfvlamseyd qmlfedervn 361 rmhesimlfd tllnskwfkd tpfilflnki dlfeekvksm pirkyfpdyq grvgdaeagl 421 kyfekiflsl nktnkpiyvk rtcatdtqtm kfvlsavtdl iiqqnlkkig ii // LOCUS NP_011869 93 aa linear PLN 30-JUN-2025 DEFINITION protein transporter TIM10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011869 VERSION NP_011869.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181427.1 REFERENCE 1 (residues 1 to 93) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 93) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 93) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 93) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06693. Method: conceptual translation. FEATURES Location/Qualifiers source 1..93 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..93 /product="protein transporter TIM10" /calculated_mol_wt="10173" Region 18..82 /region_name="zf-Tim10_DDP" /note="Tim10/DDP family zinc finger; pfam02953" /db_xref="CDD:460764" CDS 1..93 /gene="TIM10" /locus_tag="YHR005C-A" /gene_synonym="MRS11" /coded_by="NM_001181427.1:1..282" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0042719 mitochondrial intermembrane space protein transporter complex [PMID:9889188|PMID:9822593]" /experiment="EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9495346]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:12138093]" /experiment="EXISTENCE:direct assay:GO:0140318 protein transporter activity [PMID:9495346]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9430585]" /experiment="EXISTENCE:mutant phenotype:GO:0140318 protein transporter activity [PMID:9430585]" /note="Essential protein of the mitochondrial intermembrane space; forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane" /db_xref="GeneID:856395" /db_xref="SGD:S000003530" ORIGIN 1 msflgfgggq pqlssqqkiq aaeaeldlvt dmfnklvnnc ykkcintsys egelnkness 61 cldrcvakyf etnvqvgenm qkmgqsfnaa gkf // LOCUS NP_011870 541 aa linear PLN 30-JUN-2025 DEFINITION Stp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011870 VERSION NP_011870.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179136.1 REFERENCE 1 (residues 1 to 541) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 541) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 541) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 541) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06694. Method: conceptual translation. FEATURES Location/Qualifiers source 1..541 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..541 /product="Stp2p" /calculated_mol_wt="60661" Region 204..226 /region_name="zf-C2H2" /note="Zinc finger, C2H2 type; pfam00096" /db_xref="CDD:395048" Region 206..226 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(211,213,215,217..218,221..222,225,249,253,257..258, 261..262,265,291,293,295,297..298) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 234..267 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..541 /gene="STP2" /locus_tag="YHR006W" /coded_by="NM_001179136.1:1..1626" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11212916]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10648791|PMID:19906648]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21127045]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21127045]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:19906648|PMID:10648791]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10648791]" /note="Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication" /db_xref="GeneID:856397" /db_xref="SGD:S000001048" ORIGIN 1 mpilslsstr nsvltriydy lkalvqqviv pnveddkssk stpfeklepa kqnhpqkdcc 61 atekddlvdv selfpkqnnk qlsltskssv vpcalnldnl etpfsikidn ngavttqlnl 121 depilrgpsr gepaklqndl issppleesy inndqykalf psnflpitpv ssvitpaskk 181 sidesplsde vqgiadesse tlpyichycd arfrirgylt rhikkhakrk ayhcpffdns 241 isqelrchts ggfsrrdtyk thlksrhfty pegvkpqdrn kspgvctqcg ehfstseswv 301 enhieagsck glpegysegi rekkktskmk miktsdgqtr fissdesvse palqnkncie 361 atvmqskerp ndkiiptkte kndfgigtqw ferkqisrpt qttqsrgpte vqnlkewsii 421 sppilspqna ssvpqeyqss rytlhmdspa lssassalsp lsgdpittte tnksypldse 481 qsllepdkte edainqskes nmisinemlq kqmdfellge nhlketqdyl alykkaygie 541 f // LOCUS NP_011871 530 aa linear PLN 30-JUN-2025 DEFINITION sterol 14-demethylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011871 VERSION NP_011871.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179137.1 REFERENCE 1 (residues 1 to 530) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 530) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 530) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 530) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06695. Method: conceptual translation. FEATURES Location/Qualifiers source 1..530 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..530 /product="sterol 14-demethylase" /EC_number="1.14.14.154" /calculated_mol_wt="60589" Region 83..521 /region_name="CYP51-like" /note="cytochrome P450 family 51 and similar cytochrome P450s; cd11042" /db_xref="CDD:410668" Site order(126,148,151,158,311,314..315,318..319,322,374,379, 383,385,462..464,467..472,475..476) /site_type="other" /note="heme binding site [chemical binding]" /db_xref="CDD:410668" Site order(126,128..129,133,236,310,313..314,317..318,382,384) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:410668" CDS 1..530 /gene="ERG11" /locus_tag="YHR007C" /gene_synonym="CYP51" /coded_by="NM_001179137.1:1..1593" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15951236|PMID:26928762|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:105731]" /experiment="EXISTENCE:direct assay:GO:0008398 sterol 14-demethylase activity [PMID:105731|PMID:9087488]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:200835]" /note="Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation" /db_xref="GeneID:856398" /db_xref="SGD:S000001049" ORIGIN 1 msatksivge aleyvnigls hflalplaqr isliiiipfi ynivwqllys lrkdrpplvf 61 ywipwvgsav vygmkpyeff eecqkkygdi fsfvllgrvm tvylgpkghe fvfnakladv 121 saeaayahlt tpvfgkgviy dcpnsrlmeq kkfvkgaltk eafksyvpli aeevykyfrd 181 sknfrlnert tgtidvmvtq pemtiftasr sllgkemrak ldtdfaylys dldkgftpin 241 fvfpnlpleh yrkrdhaqka isgtymslik errknndiqd rdlidslmkn stykdgvkmt 301 dqeianllig vlmggqhtsa atsawillhl aerpdvqqel yeeqmrvldg gkkeltydll 361 qempllnqti ketlrmhhpl hslfrkvmkd mhvpntsyvi pagyhvlvsp gythlrdeyf 421 pnahqfnihr wnkdsassys vgeevdygfg aiskgvsspy lpfgggrhrc igehfaycql 481 gvlmsifirt lkwhypegkt vpppdftsmv tlptgpakii wekrnpeqki // LOCUS NP_878086 71 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR007C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878086 VERSION NP_878086.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184651.1 REFERENCE 1 (residues 1 to 71) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 71) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 71) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 71) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 71) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 71) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 71) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06696. Method: conceptual translation. FEATURES Location/Qualifiers source 1..71 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..71 /product="uncharacterized protein" /calculated_mol_wt="8253" CDS 1..71 /locus_tag="YHR007C-A" /coded_by="NM_001184651.1:1..216" /note="hypothetical protein; identified by expression profiling and mass spectrometry; SWAT-GFP fusion protein localizes to the nucleus" /db_xref="GeneID:1466526" /db_xref="SGD:S000028830" ORIGIN 1 mhrkkrkkek krtekdnttn lpplflfpcs lslptllapv hyiptrlthh qaenqlflll 61 fqpiivkplr s // LOCUS NP_011872 233 aa linear PLN 30-JUN-2025 DEFINITION superoxide dismutase SOD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011872 VERSION NP_011872.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179138.1 REFERENCE 1 (residues 1 to 233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 233) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06697. Method: conceptual translation. FEATURES Location/Qualifiers source 1..233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..233 /product="superoxide dismutase SOD2" /EC_number="1.15.1.1" /calculated_mol_wt="25643" Region 29..227 /region_name="SodA" /note="Superoxide dismutase [Inorganic ion transport and metabolism]; COG0605" /db_xref="CDD:440370" CDS 1..233 /gene="SOD2" /locus_tag="YHR008C" /coded_by="NM_001179138.1:1..702" /experiment="EXISTENCE:direct assay:GO:0004784 superoxide dismutase activity [PMID:15851472|PMID:238997]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:11914276|PMID:16823961|PMID:24769239|P MID:15851472]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:238997]" /experiment="EXISTENCE:mutant phenotype:GO:0072593 reactive oxygen species metabolic process [PMID:3520557]" /note="Mitochondrial manganese superoxide dismutase; protects cells against oxygen toxicity and oxidative stress; human mitochondrial SOD2 can complement a yeast null mutant and human cytoplasmic SOD1 can also complement when targeted to the mitochondrial matrix" /db_xref="GeneID:856399" /db_xref="SGD:S000001050" ORIGIN 1 mfaktaaanl tkkgglslls ttarrtkvtl pdlkwdfgal epyisgqine lhytkhhqty 61 vngfntavdq fqelsdllak epspanarkm iaiqqnikfh gggftnhclf wenlapesqg 121 ggepptgala kaideqfgsl delikltntk lagvqgsgwa fivknlsngg kldvvqtynq 181 dtvtgplvpl vaidawehay ylqyqnkkad yfkaiwnvvn wkeasrrfda gki // LOCUS NP_011873 523 aa linear PLN 30-JUN-2025 DEFINITION Tda3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011873 VERSION NP_011873.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179139.1 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 523) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06698. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..523 /product="Tda3p" /calculated_mol_wt="57483" Region <334..497 /region_name="DAO" /note="FAD dependent oxidoreductase; pfam01266" /db_xref="CDD:426168" CDS 1..523 /gene="TDA3" /locus_tag="YHR009C" /gene_synonym="BTN3" /coded_by="NM_001179139.1:1..1572" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21441304|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:21441304]" /experiment="EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:21441304]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:21441304]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:21441304]" /note="Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1" /db_xref="GeneID:856400" /db_xref="SGD:S000001051" ORIGIN 1 mgedfmhppf qtypsknseg kkhivivggg iigcctayyl tqhpsfspst hhitiiesrr 61 iaggasgkag gllaswafph qivplsfqlh qelsdeydge nnwdyrrltt vsleadvree 121 vienyerlsk kaynlnvppp kkrpgyisnk fnigdsnssl sssgsslknd sasneeegsd 181 ihvsssvpsl hsltnermrs htnsasdlds vspveqlret nihnplpadl dwirrelvnd 241 wsslggtdtt aqlhpykfth filskametg avdlllgkvv glkcdemdcv hslkylpsvv 301 knrrnsrgha enpdiklgti fndenakpie indiqqivls mgpwtskilk dcpisglrah 361 svtikpsekt vspyailael kvndreffsp emyarkdevy vcgegdtlvn ipessddvev 421 vsekcdelyh yvsklsptls kghllrkqac flpvlnvpts sgpligetnv kdlyiasghs 481 cwginnapat gklmaeilld geatsaeiss ldpklyfdat ils // LOCUS NP_011874 136 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL27 RPL27A [Saccharomyces cerevisiae S288C]. ACCESSION NP_011874 VERSION NP_011874.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179140.1 REFERENCE 1 (residues 1 to 136) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 136) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 136) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 136) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06699. Method: conceptual translation. FEATURES Location/Qualifiers source 1..136 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..136 /product="60S ribosomal protein eL27 RPL27A" /calculated_mol_wt="15400" Region 1..136 /region_name="KOW" /note="an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); cl00354" /db_xref="CDD:469738" Site order(7..15,18,22..29,42..47,52..54,56,59..61,67) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240514" CDS 1..136 /gene="RPL27A" /locus_tag="YHR010W" /gene_synonym="RPL27" /coded_by="NM_001179140.1:1..411" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication" /db_xref="GeneID:856401" /db_xref="SGD:S000001052" ORIGIN 1 makflkagkv avvvrgryag kkvvivkphd egskshpfgh alvagieryp lkvtkkhgak 61 kvakrtkikp fikvvnynhl lptrytldve afksvvstet feqpsqreea kkvvkkafee 121 rhqagknqwf fsklrf // LOCUS NP_011875 446 aa linear PLN 30-JUN-2025 DEFINITION putative serine--tRNA ligase DIA4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011875 VERSION NP_011875.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179141.1 REFERENCE 1 (residues 1 to 446) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 446) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 446) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 446) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06700. Method: conceptual translation. FEATURES Location/Qualifiers source 1..446 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..446 /product="putative serine--tRNA ligase DIA4" /EC_number="6.1.1.11" /calculated_mol_wt="50259" Region 1..440 /region_name="serS" /note="seryl-tRNA synthetase; TIGR00414" /db_xref="CDD:273066" CDS 1..446 /gene="DIA4" /locus_tag="YHR011W" /coded_by="NM_001179141.1:1..1341" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:genetic interaction:GO:0004828 serine-tRNA ligase activity [PMID:11747308]" /experiment="EXISTENCE:genetic interaction:GO:0070158 mitochondrial seryl-tRNA aminoacylation [PMID:11747308]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:11747308]" /note="Probable mitochondrial seryl-tRNA synthetase; mutant displays increased invasive and pseudohyphal growth" /db_xref="GeneID:856402" /db_xref="SGD:S000001053" ORIGIN 1 miirrlfsis nrsfflkkpq fdvkkiiemi pqyqtsiqnr elieadsiir slqllgeryq 61 nikeidkvia diqiqrksie aqikkdktki teysaalkal keqyndqnsk sselkkkile 121 tckslpntld ptvpldapqi eqwinplkth ktseaqahvd imlkknmldl qtasnvtgms 181 wyyllndgar leqalvayal kkanengfss cvppsitkke lidacgfnpr dmnnerqiya 241 lqdtnlglva taeiplaglg ankvlelnsg ecskklvgvs rcyraeagar gkdtkglyrv 301 heftkvelfc wskpetsakv leeikqfqis vveelgipak vlnmpsndlg npafkkydie 361 awmpgrgkfg eissasnctd fqsrrlntky rddntgkley vhtlngtama iprvivalve 421 nfydpstgki svpeclrefm ngqryi // LOCUS NP_011876 282 aa linear PLN 30-JUN-2025 DEFINITION retromer subunit VPS29 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011876 VERSION NP_011876.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179142.1 REFERENCE 1 (residues 1 to 282) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 282) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 282) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 282) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06701. Method: conceptual translation. FEATURES Location/Qualifiers source 1..282 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..282 /product="retromer subunit VPS29" /calculated_mol_wt="30882" Region 2..279 /region_name="MPP_superfamily" /note="metallophosphatase superfamily, metallophosphatase domain; cl13995" /db_xref="CDD:472684" Site order(8,10,40,64..65,105,134) /site_type="active" /db_xref="CDD:277317" Site order(8,10,40,64,105,134) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277317" CDS 1..282 /gene="VPS29" /locus_tag="YHR012W" /gene_synonym="PEP11; VPT6" /coded_by="NM_001179142.1:1..849" /experiment="EXISTENCE:mutant phenotype:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0140312 cargo adaptor activity [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0005768 endosome [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0030906 retromer, cargo-selective complex [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0140312 cargo adaptor activity [PMID:9700157]" /note="Subunit of the membrane-associated retromer complex; endosomal protein; essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval" /db_xref="GeneID:856403" /db_xref="SGD:S000001054" ORIGIN 1 mlllalsdah ipdratdlpv kfkkllsvpd kisqvallgn stksydflkf vnqisnniti 61 vrgefdnghl pstkkdkasd nsrpmeeipm nsiirqgalk igccsgytvv pkndplslla 121 larqldvdil lwggthnvea ytlegkffvn pgsctgafnt dwpivfdved sdeavtsevd 181 kptkenqsed ddakggstgk eqpgsytpke gtagerenen esnvkpenqf kedevdmsds 241 dingsnspsf clldiqgntc tlyiylyvng evkvdkvvye ke // LOCUS NP_011877 238 aa linear PLN 30-JUN-2025 DEFINITION peptide alpha-N-acetyltransferase complex A subunit ARD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011877 VERSION NP_011877.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179143.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 238) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06702. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..238 /product="peptide alpha-N-acetyltransferase complex A subunit ARD1" /EC_number="2.3.1.255" /calculated_mol_wt="27472" Region 94..195 /region_name="RimI" /note="Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]; COG0456" /db_xref="CDD:440224" CDS 1..238 /gene="ARD1" /locus_tag="YHR013C" /gene_synonym="NAA10" /coded_by="NM_001179143.1:1..717" /experiment="EXISTENCE:direct assay:GO:0004596 protein-N-terminal amino-acid acetyltransferase activity [PMID:2551674]" /experiment="EXISTENCE:direct assay:GO:0006474 N-terminal protein amino acid acetylation [PMID:2551674]" /experiment="EXISTENCE:direct assay:GO:0031415 NatA complex [PMID:14517307]" /experiment="EXISTENCE:mutant phenotype:GO:0004596 protein-N-terminal amino-acid acetyltransferase activity [PMID:2551674]" /experiment="EXISTENCE:mutant phenotype:GO:0006474 N-terminal protein amino acid acetylation [PMID:2551674]" /experiment="EXISTENCE:mutant phenotype:GO:0061606 N-terminal protein amino acid propionylation [PMID:23043182]" /note="Subunit of protein N-terminal acetyltransferase NatA; NatA comprises Nat1p, Ard1p, Nat5p; acetylates many proteins to influence telomeric silencing, cell cycle, heat-shock resistance, mating, sporulation, early stages of mitophagy; protein abundance increases under DNA replication stress; mutations in human homolog X-linked NAA10 lead to Ogden syndrome (S37P) and intellectual disability (R116W); expression of human NAA10 and NAA15 can complement ard1 nat1 double mutant" /db_xref="GeneID:856404" /db_xref="SGD:S000001055" ORIGIN 1 mpinirrati ndiicmqnan lhnlpenymm kyymyhilsw peasfvattt tldcedsdeq 61 dendkleltl dgtndgrtik ldptylapge klvgyvlvkm nddpdqqnep pnghitslsv 121 mrtyrrmgia enlmrqalfa lrevhqaeyv slhvrqsnra alhlyrdtla fevlsieksy 181 yqdgedayam kkvlkleelq isnfthrrlk eneekleddl esdllediik qgvndiiv // LOCUS NP_011878 291 aa linear PLN 30-JUN-2025 DEFINITION Spo13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011878 VERSION NP_011878.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179144.1 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 291) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06703. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..291 /product="Spo13p" /calculated_mol_wt="33163" CDS 1..291 /gene="SPO13" /locus_tag="YHR014W" /coded_by="NM_001179144.1:1..876" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:15620645]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12101125]" /experiment="EXISTENCE:direct assay:GO:0072687 meiotic spindle [PMID:17493939]" /experiment="EXISTENCE:mutant phenotype:GO:0045876 positive regulation of sister chromatid cohesion [PMID:12101125]" /experiment="EXISTENCE:mutant phenotype:GO:0051177 meiotic sister chromatid cohesion [PMID:15620645|PMID:15620644]" /experiment="EXISTENCE:mutant phenotype:GO:0071459 protein localization to chromosome, centromeric region [PMID:16357219]" /note="Meiotic regulator; involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II; promotes phosphorylation of Cdc5p substrates in MI and impacts Hrr25p function in MII; substrate of the anaphase-promoting complex (APC) that is degraded during anaphase I; expressed solely in meiotic cells" /db_xref="GeneID:856405" /db_xref="SGD:S000001056" ORIGIN 1 maprkrfrll elgspthskr kvqkplqekt pnlrvsplaf kigkeiknke irktkktese 61 nifnskhvdl rlesphpgln fvsdaqqysk agdvrylknk ssntlknerq tierpsfdns 121 lrfedieqpp kststpvlsq ssqinverea pmfpvpyyia pspmynfspy qnfvgnptfl 181 tpshnpnlny aipiqrpell ypnvnvydsp lfkktrlphq tksldkekny qylpiypvsi 241 snngdfvgqe tpraapklsk krlsntldvn csdyessgqn atyndsessl n // LOCUS NP_011879 659 aa linear PLN 30-JUN-2025 DEFINITION Mip6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011879 VERSION NP_011879.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179145.1 REFERENCE 1 (residues 1 to 659) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 659) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 659) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 659) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06704. Method: conceptual translation. FEATURES Location/Qualifiers source 1..659 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..659 /product="Mip6p" /calculated_mol_wt="75789" Region 111..190 /region_name="RRM1_PES4_MIP6" /note="RNA recognition motif 1 (RRM1) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins; cd21601" /db_xref="CDD:410180" Region 200..275 /region_name="RRM2_PES4_MIP6" /note="RNA recognition motif 2 (RRM2) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins; cd21602" /db_xref="CDD:410181" Region 313..385 /region_name="RRM3_PES4_MIP6" /note="RNA recognition motif 3 (RRM3) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins; cd21603" /db_xref="CDD:410182" Region 400..478 /region_name="RRM4_PES4_MIP6" /note="RNA recognition motif 4 (RRM4) found in Saccharomyces cerevisiae protein PES4, protein MIP6 and similar proteins; cd21604" /db_xref="CDD:410183" CDS 1..659 /gene="MIP6" /locus_tag="YHR015W" /coded_by="NM_001179145.1:1..1980" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:28193845]" /experiment="EXISTENCE:genetic interaction:GO:0006417 regulation of translation [PMID:28193845]" /experiment="EXISTENCE:genetic interaction:GO:0010609 mRNA localization resulting in post-transcriptional regulation of gene expression [PMID:28193845]" /experiment="EXISTENCE:genetic interaction:GO:0016071 mRNA metabolic process [PMID:28193845]" /experiment="EXISTENCE:genetic interaction:GO:0043934 sporulation [PMID:28193845]" /note="mRNA-binding protein; interacts with the UBA domain of mRNA export factor Mex67p; participates in the export of Msn2/4 stress-dependent mRNAs; partially redundant function with paralog PES4 in the steady-state expression, translational timing and localization of a subset of Ndt80-dependent mRNAs that are protected until translated near the end of meiosis II; redundant role with PES4 in sporulation; shuttles between the nucleus and cytoplasm, localizes to stress granules and the prospore membrane" /db_xref="GeneID:856408" /db_xref="SGD:S000001057" ORIGIN 1 mpnshgnvln nislnskqnp rsiskscpnd kdarqksfkt isaqalvrvq gagyklgdvk 61 lkdaevkekn slkkydckna tqekkeqeqv fektvakgsv qkyitktskt nslfignlks 121 tvteemlrki fkryqsfesa kvcrdfltkk slgygylnfk dkndaesark efnytvffgq 181 evkimpsmkn tlfrknigtn vffsnlplen pqlttrsfyl imieygnvls cllerrknig 241 fvyfdndisa rnvikkynnq effgnkiicg lhfdkevrtr peftkrkkmi gsdiviedel 301 lasnnlsdna rsktilvknl psdttqeevl dyfstigpik svfisekqan tphkafvtyk 361 neeeskkaqk clnktifknh tiwvgpgkdk pvhnqigtnk ktkvylknls fncnkefisq 421 lclqekirfs eikitnynsl nwtfcghvec fsrsdaerlf nildrrligs slveaswskn 481 ndnilneidy ddgnnnenyk klinissmmr frtqelsahq kgltsqfqqv vspfssysns 541 ytnmnslvat pmkphpafnl itntvdeklh qpkrtkqena eileslkkii nrnlqrisis 601 glnkeenlrs isefifdvfw ehdserlshf llmtntsles qkilqkqvtr aaeslgftv // LOCUS NP_011880 468 aa linear PLN 30-JUN-2025 DEFINITION Ysc84p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011880 VERSION NP_011880.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179146.1 REFERENCE 1 (residues 1 to 468) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 468) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 468) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 468) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06705. Method: conceptual translation. FEATURES Location/Qualifiers source 1..468 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..468 /product="Ysc84p" /calculated_mol_wt="50771" Region 13..213 /region_name="SYLF_SH3YL1_like" /note="The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins; cd11525" /db_xref="CDD:211401" Site 13..26 /site_type="other" /note="putative amphipathic alpha helix" /db_xref="CDD:211401" Site order(16..17,20,23) /site_type="other" /note="putative lipid binding residues [chemical binding]" /db_xref="CDD:211401" Region 413..467 /region_name="SH3_Ysc84p_like" /note="Src homology 3 domain of Ysc84p and similar fungal proteins; cd11842" /db_xref="CDD:212776" Site order(418,420,423,427,447..448,461,463..464) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212776" CDS 1..468 /gene="YSC84" /locus_tag="YHR016C" /gene_synonym="LSB4" /coded_by="NM_001179146.1:1..1407" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:12388763]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:19158382]" /experiment="EXISTENCE:direct assay:GO:0051017 actin filament bundle assembly [PMID:19158382]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:12388763]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:12388763]" /experiment="EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:19158382]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:19158382]" /note="Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication" /db_xref="GeneID:856409" /db_xref="SGD:S000001058" ORIGIN 1 mginnpiprs lksetkkaak vlrsfvkpnq vfgadqvipp yvlkrakgla iitvlkagfl 61 fsgragsgvi varlkdgtws apsaiamaga gaggmvgvel tdfvfilnse eavrsfsefg 121 titlggnvsv sagplgrsae aaasastggv savfaysksk glfagvsveg sailerrean 181 rkfygdncts kmilsgrvkv ppaadpllri lesrafnftr hdhddnasgd dfyddgqysd 241 ntshyyddip dsfdstdess trpntrssrr rgmslgsrsr ydddydddgy grgrgygdfd 301 sededydygr spnrnssrnr gpqidrgtkp rantrweddl ydrdteysrp nhsgrdydnt 361 rgnrrgygre rgyslghgpt hpsnmsnvdd lshkmsktgl gnestatnsa tptavalynf 421 ageqpgdlaf kkgdvitilk ksdsqndwwt grtngkegif panyvrvs // LOCUS NP_011881 385 aa linear PLN 30-JUN-2025 DEFINITION Ysc83p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011881 VERSION NP_011881.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179147.1 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 385) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06706. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..385 /product="Ysc83p" /calculated_mol_wt="44104" Region 106..359 /region_name="DUF1776" /note="Fungal family of unknown function (DUF1776); pfam08643" /db_xref="CDD:370028" CDS 1..385 /gene="YSC83" /locus_tag="YHR017W" /coded_by="NM_001179147.1:1..1158" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /note="Non-essential mitochondrial hypothetical protein; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83" /db_xref="GeneID:856410" /db_xref="SGD:S000001059" ORIGIN 1 mawsggkdiv dqifdagywl vsksavlsde iknhveksie sisgkisnke tprlqendsn 61 rskvyktlri glqdhwklgl gisatslcly lgyrtffklp pnlpeaesqv vlilgdmndp 121 iirnqvmdly rrrftvyict enadvykkhe edqdfiyyid ptcekdfegf fvdvprlasi 181 lfmprlsyhp sgviscdsle seihssifvy yqallsiiph lkrktqlimf npsltadlnl 241 vhhsteiits giidslfkif keyqrlnvst iklgilqigs qpsnykflrm agsdihealh 301 ypvykmimsa ngyklrqlls wlttlggyns vyycgrfsyl vswpfaslif nhhtrlslkr 361 lrgrlakvys siisffcrss skssk // LOCUS NP_011882 463 aa linear PLN 30-JUN-2025 DEFINITION argininosuccinate lyase ARG4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011882 VERSION NP_011882.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179148.1 REFERENCE 1 (residues 1 to 463) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 463) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 463) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 463) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06707. Method: conceptual translation. FEATURES Location/Qualifiers source 1..463 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..463 /product="argininosuccinate lyase ARG4" /EC_number="4.3.2.1" /calculated_mol_wt="51858" Region 8..463 /region_name="argH" /note="argininosuccinate lyase; TIGR00838" /db_xref="CDD:129918" CDS 1..463 /gene="ARG4" /locus_tag="YHR018C" /coded_by="NM_001179148.1:1..1392" /experiment="EXISTENCE:direct assay:GO:0004056 argininosuccinate lyase activity [PMID:4578972]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:205532]" /experiment="EXISTENCE:direct assay:GO:0042450 L-arginine biosynthetic process via ornithine [PMID:4578972]" /note="Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway" /db_xref="GeneID:856411" /db_xref="SGD:S000001060" ORIGIN 1 msdgtqklwg grftgetdpl mhlynaslpy dykmykadle gtkvytaglq klglltetel 61 akiheglaei kkewdadkfv rhpndediht anerrlgeli grdiagkvht grsrndqvvt 121 dlriycrdiv ndtlfpalkg lvevlikrae geidvlmpgy thlqraqpir wshwlssyat 181 yftedykrlg qilhrlnqsp lgagalaghp ygidreflae glgfnsvign slvavsdrdf 241 ivelmfwgtl fmnhisrfae dliiyctaef gfiqlsdays tgsslmpqkk nadslellrg 301 ksgrvfgdlt gflmslkgip stydkdmqed keplfdcltt vehsmliatg vistltvnke 361 kmeaaltmdm latdladylv rkgvpfreth hisgecvata erlglsgidk ltleqyqkid 421 srfgqdlfet fnfeqsverr datggtaksa vlkqldnlks qln // LOCUS NP_011883 554 aa linear PLN 30-JUN-2025 DEFINITION asparagine--tRNA ligase DED81 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011883 VERSION NP_011883.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179149.1 REFERENCE 1 (residues 1 to 554) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 554) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 554) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06708. Method: conceptual translation. FEATURES Location/Qualifiers source 1..554 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..554 /product="asparagine--tRNA ligase DED81" /EC_number="6.1.1.22" /calculated_mol_wt="62076" Region 114..554 /region_name="asnS" /note="asparaginyl-tRNA synthetase; TIGR00457" /db_xref="CDD:273086" CDS 1..554 /gene="DED81" /locus_tag="YHR019C" /coded_by="NM_001179149.1:1..1665" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:9605503]" /experiment="EXISTENCE:direct assay:GO:0004816 asparagine-tRNA ligase activity [PMID:9605503]" /experiment="EXISTENCE:direct assay:GO:0006421 asparaginyl-tRNA aminoacylation [PMID:9605503]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Cytosolic asparaginyl-tRNA synthetase; required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA" /db_xref="GeneID:856412" /db_xref="SGD:S000001061" ORIGIN 1 msslyikeat gvdelttags qdhpfktpay alfasqqksd atepklfvfk tedneyqeis 61 asalkkarkg cdglkkkavk qkeqelkkqq keaenaakql salnitiked eslpaaiktr 121 iydsyskvgq rvkvsgwihr lrsnkkvifv vlrdgsgfiq cvlsgdlala qqtldltles 181 tvtlygtivk lpegktapgg velnvdyyev vglapggeds ftnkiaegsd psllldqrhl 241 alrgdalsav mkvraallks vrrvydeehl tevtppcmvq tqveggstlf kmnyygeeay 301 ltqssqlyle tclaslgdvy tiqesfraek shtrrhlsey thieaelafl tfddllqhie 361 tlivksvqyv ledpiagplv kqlnpnfkap kapfmrlqyk daitwlnehd ikneegedfk 421 fgddiaeaae rkmtdtigvp ifltrfpvei ksfymkrcsd dprvtesvdv lmpnvgeitg 481 gsmriddmde lmagfkregi dtdayywfid qrkygtcphg gygigteril awlcdrftvr 541 dcslyprfsg rckp // LOCUS NP_011884 688 aa linear PLN 30-JUN-2025 DEFINITION proline--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011884 VERSION NP_011884.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179150.1 REFERENCE 1 (residues 1 to 688) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 688) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 688) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 688) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06709. Method: conceptual translation. FEATURES Location/Qualifiers source 1..688 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..688 /product="proline--tRNA ligase" /EC_number="6.1.1.15" /calculated_mol_wt="77255" Region 24..>106 /region_name="YbaK_like" /note="YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; cl00022" /db_xref="CDD:444658" Region 188..688 /region_name="proS_fam_I" /note="prolyl-tRNA synthetase, family I; TIGR00408" /db_xref="CDD:273062" CDS 1..688 /locus_tag="YHR020W" /coded_by="NM_001179150.1:1..2067" /experiment="EXISTENCE:direct assay:GO:0004827 proline-tRNA ligase activity [PMID:16864571]" /experiment="EXISTENCE:direct assay:GO:0006433 prolyl-tRNA aminoacylation [PMID:16864571]" /note="Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments" /db_xref="GeneID:856413" /db_xref="SGD:S000001062" ORIGIN 1 mpvseafakl cvnekppaes avavkslvfk pktpksatpv pivvvalqst ttpsaliana 61 tsskdprlar ddlvkqafqs esarafilgd lanatsnfhl lidhelgtvd gdtilqlnds 121 tymkksdmmk flnnfedsqk vvdfsqevsk etategkkqq kkqqpskagt aaaaaaaale 181 dakligitvd kaldfpgwyq qiltkgemld yydvsgcyil rppsyaiwen iqkwfddkik 241 aigvqnayfp mfvssrvlek ekdhvegfap evawvtrags seleepiair ptsetvmypy 301 yakwvqsyrd lplklnqwns vvrwefkhpq pflrtreflw qeghtahlta kdaeeevlqi 361 ldfyagvyee llavpvvkgr ktekekfagg dftttcegyi pqtgrgiqga tshhlgqnfs 421 kmfnlsvenp lgsdhpkifa yqnswglstr vigvmvmihs dnkglvippr vsqfqsvvip 481 vgitkktsee qrkhihetar svesrlkkvg irafgdyndn ytpgwkfsqy elkgipirie 541 lgpkdieknq vvvvrrndsk kyvvsfdele aripeileem qgdlfkkake lfdthrvivn 601 ewsgfvpaln kknvilapwc gvmeceedik essakkddge efeeddkaps mgakslcipf 661 dqpvlnegqk cikceriavn ycmfgrsy // LOCUS NP_011885 82 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS27 RPS27B [Saccharomyces cerevisiae S288C]. ACCESSION NP_011885 VERSION NP_011885.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179151.1 REFERENCE 1 (residues 1 to 82) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 82) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 82) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 82) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06710. Method: conceptual translation. FEATURES Location/Qualifiers source 1..82 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..82 /product="40S ribosomal protein eS27 RPS27B" /calculated_mol_wt="8734" Region 5..82 /region_name="PTZ00083" /note="40S ribosomal protein S27; Provisional" /db_xref="CDD:185434" CDS 1..82 /gene="RPS27B" /locus_tag="YHR021C" /coded_by="NM_001179151.1:1..249" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:9271380]" /experiment="EXISTENCE:mutant phenotype:GO:0000479 endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9271380]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27B has a paralog, RPS27A, that arose from the whole genome duplication" /db_xref="GeneID:856415" /db_xref="SGD:S000001063" ORIGIN 1 mvlvqdllhp taasearkhk lktlvqgprs yfldvkcpgc lnittvfsha qtavtcescs 61 tvlctptggk aklsegtsfr rk // LOCUS NP_011886 151 aa linear PLN 30-JUN-2025 DEFINITION Ecm12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011886 VERSION NP_011886.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181428.1 REFERENCE 1 (residues 1 to 151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 151) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06711. Method: conceptual translation. FEATURES Location/Qualifiers source 1..151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..151 /product="Ecm12p" /calculated_mol_wt="17303" CDS 1..151 /gene="ECM12" /locus_tag="YHR021W-A" /coded_by="NM_001181428.1:1..456" /note="hypothetical protein; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity" /db_xref="GeneID:856416" /db_xref="SGD:S000003531" ORIGIN 1 mnrsfhflik yiyihvllvf yfhikqqaim pffifffssf dglsfdlrvv aflakhvfvg 61 vcspffvvgf fgssrvvvte wlsklvlppp pvsitqvfsl srkrgefssg yiliinpyks 121 flrslldfsi fnntaknkss tftlnledvs k // LOCUS NP_011887 256 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR022C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011887 VERSION NP_011887.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179152.1 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 256) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06712. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..256 /product="uncharacterized protein" /calculated_mol_wt="28865" Region 27..242 /region_name="Ras_like_GTPase" /note="Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); cd00882" /db_xref="CDD:206648" Site 29..36 /site_type="other" /note="G1 box" /db_xref="CDD:206648" Site order(31..37,192..193,195,227..229) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206648" Site 64 /site_type="other" /note="G2 box" /db_xref="CDD:206648" Site 68..70 /site_type="other" /note="Switch I region" /db_xref="CDD:206648" Site 192..195 /site_type="other" /note="G4 box" /db_xref="CDD:206648" Site 227..229 /site_type="other" /note="G5 box" /db_xref="CDD:206648" CDS 1..256 /locus_tag="YHR022C" /coded_by="NM_001179152.1:1..771" /note="hypothetical protein; YHR022C is not an essential gene" /db_xref="GeneID:856417" /db_xref="SGD:S000001064" ORIGIN 1 msvrlsygas lasiprcfdl ksskitvmgd dhsgktslvr swlgssfqis danryrvsdl 61 yhktiqfdtl vkyyrtfgvk gqlpnyagfk aknsgtiyes cgnfleerli nankstaqrr 121 tsidvqvfdt nqmevsylse lttlqirqsd aiilcfdstn dsslaslesy iciihhvrle 181 celdipiiia ctkcdldser tithekvltf iqelgfspgn ldyfetsskf nvnvedlfla 241 vllkieksks drrkll // LOCUS NP_878087 29 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR022C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878087 VERSION NP_878087.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184597.1 REFERENCE 1 (residues 1 to 29) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 29) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 29) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 29) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06713. Method: conceptual translation. FEATURES Location/Qualifiers source 1..29 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..29 /product="uncharacterized protein" /calculated_mol_wt="3374" CDS 1..29 /locus_tag="YHR022C-A" /coded_by="NM_001184597.1:1..90" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466527" /db_xref="SGD:S000028645" ORIGIN 1 mkikfsrgar fsatfsfdky pfllyevvr // LOCUS NP_011888 1928 aa linear PLN 30-JUN-2025 DEFINITION myosin 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011888 VERSION NP_011888.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179153.1 REFERENCE 1 (residues 1 to 1928) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1928) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1928) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1928) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06714. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1928 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1928 /product="myosin 1" /calculated_mol_wt="223506" Region 2..1691 /region_name="COG5022" /note="Myosin heavy chain [General function prediction only]" /db_xref="CDD:227355" Region 1607..>1901 /region_name="Smc" /note="Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; COG1196" /db_xref="CDD:440809" CDS 1..1928 /gene="MYO1" /locus_tag="YHR023W" /coded_by="NM_001179153.1:1..5787" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9732290]" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:9442111]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9732290]" /experiment="EXISTENCE:direct assay:GO:1904498 protein localization to mitotic actomyosin contractile ring [PMID:15210731]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:21173112]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:9732290]" /experiment="EXISTENCE:mutant phenotype:GO:0031671 primary cell septum biogenesis [PMID:21173112]" /experiment="EXISTENCE:mutant phenotype:GO:1902404 mitotic actomyosin contractile ring contraction [PMID:16148042|PMID:21173112|PMID:9864366]" /experiment="EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:9732290|PMID:21173112]" /experiment="EXISTENCE:mutant phenotype:GO:1904498 protein localization to mitotic actomyosin contractile ring [PMID:23468521]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:21173112|PMID:11082046|PMID:23468521]" /experiment="EXISTENCE:physical interaction:GO:0016460 myosin II complex [PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0032027 myosin light chain binding [PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0032033 myosin II light chain binding [PMID:11082046]" /note="Type II myosin heavy chain; required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively" /db_xref="GeneID:856418" /db_xref="SGD:S000001065" ORIGIN 1 mtggqscssn mivwipdeke vfvkgelmst dinknkftgq eeqigivhpl dstevsnlvq 61 vrisdvfpvn pstfdkvenm selthlneps vlynlekryd cdliytysgl flvainpyhn 121 lnlysedhin lyhnkhnrls ksrldenshe klpphifaia eeayenllse gkdqsilvtg 181 esgagktent kkilqylasi tsgspsniap vsgssivesf emkilqsnpi lesfgnaqtv 241 rnnnssrfgk fikiefnehg mingahiewy lleksrivhq nskernyhif yqllsgldds 301 elknlrlksr nvkdykilsn snqdiipgin dvenfkells alniigfskd qirwifqvva 361 iillignief vsdraeqasf kndvsaicsn lgvdekdfqt ailrprskag kewvsqskns 421 qqakfilnal srnlyerlfg yivdminknl dhgsatlnyi glldiagfei fennsfeqlc 481 inytneklqq ffnnhmfvle qseylkeniq wdyidygkdl qltidliesk gpptgvlpll 541 deeavlpkst desfysklis twdqnsskfk rsrlkngfil khyagdveyt vegwlsknkd 601 plndnllsll sssqndiisk lfqpegekss sagveanisn qevkksarts tfkttssrhr 661 eqqitllnql asthphfvrc iipnnvkkvk tfnrrlildq lrcngvlegi rlaregypnr 721 iafqeffqry rilypenstt ttfssklkas tkqncefllt slqldtkvyk igntklffka 781 gvladlekqk dvklnnimik ltatirgytv rkeityhlqk lkktrvignt frlynrlvke 841 dpwfnlfiri kplltssndm trtkkfneqi nklkndlqem eskkkfleek nqktvnelen 901 tqdllnqeke nlrkneslln rvktssetlq kqfddlvsek deisreklev aqnleeahqk 961 iqglqetire reatleklhs knnelikqis dlncdiskeq ssqslikesk lkleneikrl 1021 kdvinskeee iksfndklss seedldiklv tlekncniam srlqslvten sdlrsknenf 1081 kkekaalnnq lknkesellk mkekidnhkk elatfskqrd davsehgkit aelketriql 1141 teyksnyqki keeysnfqre tkeqeqkkrn slveslndsk ikelearlsq eislnqylnk 1201 risgnsvetn isstrrstsy sddpldkedi ikkyydlqla fteitrnlen eieekknlis 1261 rlrftetrla sssfedqkik aqmkklkkli qdmdpsipld silnepldnc pdkesdinkl 1321 mlevdylkrq ldietrahyd aenaisalhs kfrkiqgess lsssdiyklk feaseervks 1381 ledklktmpl rdrtnlpvgd iiknrdsisk yeeeiryykl enyklqeiln esngklsqlt 1441 ldlrqskske allseqldrl qkdlesterq kellsstikq qkqqfencmd dlqgnelrlr 1501 ehihalkqae edvknmasii eklktqnkqk ekliwereme rndsdmqlqe tllelkrvqd 1561 vkkilsddla hlkerlsave drsqytdein rlkeelncsl kaetnlkkef atlkyklets 1621 tndseakisd llkqldhytk vvemlnnekd aislaekely qkyealntec eslkgkivsl 1681 tkikqelesd lnqktdalqi snaalssstq knkeitekik yleetlqlqm eqnsrngelv 1741 ktlqascngy kdkfddekqk nidlyeenqt lqklntdlql qlknlherls dtteknawls 1801 kihelenmvs letdlkyeem kknkslerav eelqtknsqq tdvielankn rsefeeatlk 1861 yeaqisdlek yisqqelemk ksirdnssyr dkvqemaqei efwksryest migsknidsn 1921 naqskifs // LOCUS NP_011889 482 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial-processing protease subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_011889 VERSION NP_011889.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179154.1 REFERENCE 1 (residues 1 to 482) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 482) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 482) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 482) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06715. Method: conceptual translation. FEATURES Location/Qualifiers source 1..482 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..482 /product="mitochondrial-processing protease subunit alpha" /calculated_mol_wt="53207" Region 24..431 /region_name="PqqL" /note="Predicted Zn-dependent peptidase, M16 family [General function prediction only]; COG0612" /db_xref="CDD:440377" CDS 1..482 /gene="MAS2" /locus_tag="YHR024C" /gene_synonym="MIF2" /coded_by="NM_001179154.1:1..1449" /experiment="EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:2905264]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0017087 mitochondrial processing peptidase complex [PMID:2905264]" /experiment="EXISTENCE:mutant phenotype:GO:0006627 protein processing involved in protein targeting to mitochondrion [PMID:3061808]" /note="Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" /db_xref="GeneID:856419" /db_xref="SGD:S000001066" ORIGIN 1 mlrngvqrly sniartdnfk lsslanglkv atsntpghfs alglyidags rfegrnlkgc 61 thildrlafk stehvegram aetlellggn yqctssrenl myqasvfnqd vgkmlqlmse 121 tvrfpkiteq elqeqklsae yeidevwmkp elvlpellht aaysgetlgs plicprelip 181 siskyylldy rnkfytpent vaafvgvphe kaleltekyl gdwqsthppi tkkvaqytgg 241 escippapvf gnlpelfhiq igfeglpidh pdiyalatlq tllggggsfs aggpgkgmys 301 rlythvlnqy yfvencvafn hsysdsgifg islscipqaa pqaveviaqq myntfankdl 361 rltedevsra knqlkssllm nlesklvele dmgrqvlmhg rkipvnemis kiedlkpddi 421 srvaemiftg nvnnagngkg ratvvmqgdr gsfgdvenvl kayglgnsss skndspkkkg 481 wf // LOCUS NP_011890 357 aa linear PLN 30-JUN-2025 DEFINITION homoserine kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011890 VERSION NP_011890.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179155.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 357) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06716. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..357 /product="homoserine kinase" /EC_number="2.7.1.39" /calculated_mol_wt="38581" Region 5..355 /region_name="thrB" /note="homoserine kinase; TIGR00191" /db_xref="CDD:129295" CDS 1..357 /gene="THR1" /locus_tag="YHR025W" /coded_by="NM_001179155.1:1..1074" /experiment="EXISTENCE:direct assay:GO:0004413 homoserine kinase activity [PMID:2165904]" /experiment="EXISTENCE:direct assay:GO:0009092 homoserine metabolic process [PMID:2165904]" /experiment="EXISTENCE:mutant phenotype:GO:0009088 threonine biosynthetic process [PMID:17247984]" /note="Homoserine kinase; conserved protein required for threonine biosynthesis; long-lived protein that is preferentially retained in mother cells and forms cytoplasmic filaments; expression is regulated by the GCN4-mediated general amino acid control pathway" /db_xref="GeneID:856420" /db_xref="SGD:S000001067" ORIGIN 1 mvrafkikvp assanigpgy dvlgvglslf leldvtidss qaqetnddpn ncklsytkes 61 egystvplrs danlitrtal yvlrcnnirn fpsgtkvhvs npiplgrglg ssgaavvagv 121 ilgnevaqlg fskqrmldyc lmierhpdni taammggfcg sflrdltpqe verreiplae 181 vlpepsgged tglvpplppt digrhvkyqw npaikciaii pqfelstads rgvlpkaypt 241 qdlvfnlqrl avlttaltmd ppnadliypa mqdrvhqpyr ktlipgltei lscvtpstyp 301 gllgiclsga gptilalate nfeeisqeii nrfakngikc swkllepayd gasveqq // LOCUS NP_011891 213 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V0 sector ATPase subunit c'' [Saccharomyces cerevisiae S288C]. ACCESSION NP_011891 VERSION NP_011891.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179156.1 REFERENCE 1 (residues 1 to 213) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 213) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 213) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 213) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06717. Method: conceptual translation. FEATURES Location/Qualifiers source 1..213 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..213 /product="H(+)-transporting V0 sector ATPase subunit c''" /calculated_mol_wt="22465" Region 59..121 /region_name="ATP-synt_Vo_c_ATP6F_rpt1" /note="V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins; cd18177" /db_xref="CDD:349417" Region 141..>192 /region_name="ATP-synt_Vo_c_ATP6F_rpt2" /note="V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins; cd18178" /db_xref="CDD:349418" CDS 1..213 /gene="VMA16" /locus_tag="YHR026W" /gene_synonym="PPA1" /coded_by="NM_001179156.1:1..642" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15252052]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:9030535]" /note="Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain" /db_xref="GeneID:856421" /db_xref="SGD:S000001068" ORIGIN 1 mnkeskdddm slgkfsfshf lyylvlivvi vyglyklftg hgsdinfgkf llrtspymwa 61 nlgialcvgl svvgaawgif itgssmigag vraprittkn lisiifcevv aiygliiaiv 121 fsskltvata enmysksnly tgyslfwagi tvgasnlicg iavgitgata aisdaadsal 181 fvkilvieif gsilgllgli vgllmagkas efq // LOCUS NP_011892 993 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle base subunit RPN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011892 VERSION NP_011892.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179157.1 REFERENCE 1 (residues 1 to 993) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 993) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 993) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 993) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 993) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 993) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 993) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06718. Method: conceptual translation. FEATURES Location/Qualifiers source 1..993 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..993 /product="proteasome regulatory particle base subunit RPN1" /calculated_mol_wt="109361" Region 1..993 /region_name="RPN1" /note="26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]; COG5110" /db_xref="CDD:227441" CDS 1..993 /gene="RPN1" /locus_tag="YHR027C" /gene_synonym="HRD2; NAS1" /coded_by="NM_001179157.1:1..2982" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15210724|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:12198498]" /note="Non-ATPase base subunit of the 19S RP of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions; RP is the acronym for regulatory particle" /db_xref="GeneID:856422" /db_xref="SGD:S000001069" ORIGIN 1 mvdesdkkqq tideqsqisp ekqtpnkkdk kkeeeeqlse edaklktdle llverlkedd 61 sslyeaslna lkesiknsts smtavpkplk flrptypdlc siydkwtdpn lkssladvls 121 ilamtyseng khdslryrll sdvsdfegwg heyirhlale igevyndqve kdaedetssd 181 gsksdgsaat sgfefskedt lrlcldivpy flkhngeeda vdllleiesi dklpqfvden 241 tfqrvcqymv acvpllpppe dvaflktays iylsqneltd aialavrlge edmirsvfda 301 tsdpvmhkql ayilaaqkts feyegvqdii gngklsehfl ylakelnltg pkvpediyks 361 hldnsksvfs sagldsaqqn lassfvngfl nlgycndkli vdndnwvykt kgdgmtsava 421 sigsiyqwnl dglqqldkyl yvdepevkag allgigisas gvhdgevepa llllqdyvtn 481 pdtkissaai lglgiafags kndevlglll piaastdlpi etaamaslal ahvfvgtcng 541 dittsimdnf lertaielkt dwvrflalal gilymgqgeq vddvletisa iehpmtsaie 601 vlvgscaytg tgdvlliqdl lhrltpknvk geedadeeet aegqtnsisd flgeqvnept 661 kneeaeievd emevdaegee vevkaeitek kngeslegee ikseekkgks sdkdattdgk 721 nddeeeekea givdelayav lgialialge digkemslrh fghlmhygne hirrmvplam 781 givsvsdpqm kvfdtltrfs hdadlevsmn sifamglcga gtnnarlaql lrqlasyysr 841 eqdalfitrl aqgllhlgkg tmtmdvfnda hvlnkvtlas ilttavglvs psfmlkhhql 901 fymlnagirp kfilalndeg epikvnvrvg qavetvgqag rpkkitgwit qstpvllnhg 961 eraeletdey isytshiegv vilkknpdyr eee // LOCUS NP_011893 818 aa linear PLN 30-JUN-2025 DEFINITION dipeptidyl aminopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011893 VERSION NP_011893.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179158.1 REFERENCE 1 (residues 1 to 818) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 818) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 818) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 818) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06719. Method: conceptual translation. FEATURES Location/Qualifiers source 1..818 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..818 /product="dipeptidyl aminopeptidase" /calculated_mol_wt="93274" Region 148..508 /region_name="DPPIV_N" /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region; pfam00930" /db_xref="CDD:395744" Region 608..815 /region_name="Peptidase_S9" /note="Prolyl oligopeptidase family; pfam00326" /db_xref="CDD:459761" CDS 1..818 /gene="DAP2" /locus_tag="YHR028C" /gene_synonym="DPP2" /coded_by="NM_001179158.1:1..2457" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:2647766]" /experiment="EXISTENCE:direct assay:GO:0008239 dipeptidyl-peptidase activity [PMID:2647766]" /note="Dipeptidyl aminopeptidase; synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p" /db_xref="GeneID:856423" /db_xref="SGD:S000001070" ORIGIN 1 meggeeever ipdelfdtkk khlldklirv giilvlliwg tvlllksiph hsntpdyqep 61 nsnytndgkl kvsfsvvrnn tfqpkyhelq wisdnkiesn dlglyvtfmn dsyvvksvyd 121 dsynsvlleg ktfihngqnl tvesitaspd lkrllirtns vqnwrhstfg syfvydksss 181 sfeeigneva laiwspnsnd iayvqdnniy iysaiskkti ravtndgssf lfngkpdwvy 241 eeevfeddka awwsptgdyl aflkidesev gefiipyyvq dekdiypemr sikypksgtp 301 nphaelwvys mkdgtsfhpr isgnkkdgsl litevtwvgn gnvlvkttdr ssdiltvfli 361 dtiaktsnvv rnessnggww eithntlfip anetfdrphn gyvdilpigg ynhlayfens 421 nsshyktlte gkwevvngpl afdsmenrly fistrksste rhvyyidlrs pneiievtdt 481 sedgvydvsf ssgrrfgllt ykgpkvpyqk ivdfhsrkae kcdkgnvlgk slyhleknev 541 ltkiledyav prksfrelnl gkdefgkdil vnsyeilpnd fdetlsdhyp vfffayggpn 601 sqqvvktfsv gfnevvasql naivvvvdgr gtgfkgqdfr slvrdrlgdy eardqisaas 661 lygsltfvdp qkislfgwsy ggyltlktle kdggrhfkyg msvapvtdwr fydsvytery 721 mhtpqenfdg yvessvhnvt alaqanrfll mhgtgddnvh fqnslkfldl ldlngvenyd 781 vhvfpdsdhs iryhnanviv fdklldwakr afdgqfvk // LOCUS NP_011894 294 aa linear PLN 30-JUN-2025 DEFINITION Yhi9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011894 VERSION NP_011894.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179159.1 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 294) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06720. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..294 /product="Yhi9p" /calculated_mol_wt="32432" Region 3..294 /region_name="PhzF_family" /note="phenazine biosynthesis protein PhzF family; TIGR00654" /db_xref="CDD:129739" CDS 1..294 /gene="YHI9" /locus_tag="YHR029C" /coded_by="NM_001179159.1:1..885" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:31323700]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16582425]" /note="hypothetical protein; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production" /db_xref="GeneID:856424" /db_xref="SGD:S000001071" ORIGIN 1 mtlmvpfkqv dvftekpfmg npvavinfle idenevsqee lqaianwtnl settflfkps 61 dkkydyklri ftprselpfa ghptigscka fleftkntta tslvqeckig avpitinegl 121 isfkapmady esissemiad yekaiglkfi kppallhtgp ewivalveda etcfnanpnf 181 amlahqtkqn dhvgiilagp kkeaaiknsy emrafapvin vyedpvcgsg svalarylqe 241 vykfekttdi tiseggrlkr nglmlasikk eadnstsyyi aghattvidg kikv // LOCUS NP_011895 484 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated serine/threonine-protein kinase SLT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011895 VERSION NP_011895.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179160.1 REFERENCE 1 (residues 1 to 484) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 484) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 484) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 484) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06721. Method: conceptual translation. FEATURES Location/Qualifiers source 1..484 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..484 /product="mitogen-activated serine/threonine-protein kinase SLT2" /EC_number="2.7.11.24" /calculated_mol_wt="55505" Region 22..355 /region_name="STKc_MPK1" /note="Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; cd07857" /db_xref="CDD:173750" Site order(29..32,34..35,37,52,54,71,86,108..111,114,116..117, 153,155,157..158,160,170..171,174,190,192..195,197,235) /site_type="active" /db_xref="CDD:173750" Site order(29..32,34..35,37,52,54,86,108..111,114,117,155, 157..158,160,170..171) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:173750" Site order(71,116,153,155,174,190,192..195,197,235) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:173750" Site order(83,112..113,118,129,132,139,161..165,321,323,326) /site_type="other" /note="KIM docking site [polypeptide binding]" /db_xref="CDD:173750" Site 170..197 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:173750" CDS 1..484 /gene="SLT2" /locus_tag="YHR030C" /gene_synonym="BYC2; LYT2; MPK1; SLK2" /coded_by="NM_001179160.1:1..1455" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:24554767|PMID:20823268]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23924898|PMID:26928762|PMID:12361575]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25598154]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12361575|PMID:23924898]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12361575|PMID:23924898]" /experiment="EXISTENCE:direct assay:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16380504]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12361575]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:8386319|PMID:8386320]" /experiment="EXISTENCE:genetic interaction:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]" /experiment="EXISTENCE:genetic interaction:GO:0010973 positive regulation of division septum assembly [PMID:19633265|PMID:27400980]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:8386319]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20385774]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:8386319]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:17302939]" /experiment="EXISTENCE:mutant phenotype:GO:0010447 response to acidic pH [PMID:16087742]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16380504]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:27117666]" /experiment="EXISTENCE:mutant phenotype:GO:0036498 IRE1-mediated unfolded protein response [PMID:18971375]" /experiment="EXISTENCE:mutant phenotype:GO:0042306 regulation of protein import into nucleus [PMID:20219973]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:8386319]" /experiment="EXISTENCE:mutant phenotype:GO:0060256 regulation of flocculation [PMID:31441971]" /experiment="EXISTENCE:mutant phenotype:GO:0090364 regulation of proteasome assembly [PMID:27462806]" /note="Serine/threonine MAP kinase; coordinates expression of all 19S regulatory particle assembly-chaperones (RACs) to control proteasome abundance; involved in regulating maintenance of cell wall integrity, cell cycle progression, nuclear mRNA retention in heat shock, septum assembly; required for mitophagy, pexophagy; affects recruitment of mitochondria to phagophore assembly site; plays role in adaptive response of cells to cold; regulated by the PKC1-mediated signaling pathway" /db_xref="GeneID:856425" /db_xref="SGD:S000001072" ORIGIN 1 madkierhtf kvfnqdfsvd krfqlikeig hgaygivcsa rfaeaaedtt vaikkvtnvf 61 sktllckrsl relkllrhfr ghknitclyd mdivfypdgs inglylyeel mecdmhqiik 121 sgqpltdahy qsftyqilcg lkyihsadvl hrdlkpgnll vnadcqlkic dfglargyse 181 npvensqflt eyvatrwyra peimlsyqgy tkaidvwsag cilaeflggk pifkgkdyvn 241 qlnqilqvlg tppdetlrri gsknvqdyih qlgfipkvpf vnlypnansq aldlleqmla 301 fdpqkritvd ealehpylsi whdpadepvc sekfefsfes vndmedlkqm viqevqdfrl 361 fvrqplleeq rqlqlqqqqq qqqqqqqqqq qpsdvdngna aaseenypkq matsnsvapq 421 qesfgihsqn lprhdadfpp rpqesmmemr patgntadip pqndngtlld lekelefgld 481 rkyf // LOCUS NP_011896 723 aa linear PLN 30-JUN-2025 DEFINITION DNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011896 VERSION NP_011896.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179161.1 REFERENCE 1 (residues 1 to 723) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 723) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 723) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 723) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 723) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 723) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 723) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06722. Method: conceptual translation. FEATURES Location/Qualifiers source 1..723 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..723 /product="DNA helicase" /EC_number="3.6.4.12" /calculated_mol_wt="81450" Region <232..696 /region_name="RecD" /note="ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair]; COG0507" /db_xref="CDD:440273" Region 235..414 /region_name="DEXSc_Pif1_like" /note="DEAD-box helicase domain of Pif1; cd18037" /db_xref="CDD:350795" Site order(236,255..262,337,377) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350795" CDS 1..723 /gene="RRM3" /locus_tag="YHR031C" /gene_synonym="RTT104" /coded_by="NM_001179161.1:1..2172" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:12050116]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:17114583|PMID:26411679]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:30442759]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:26981397]" /experiment="EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:15907372]" /experiment="EXISTENCE:genetic interaction:GO:0071932 replication fork reversal [PMID:26411679]" /experiment="EXISTENCE:mutant phenotype:GO:0005657 replication fork [PMID:17114583]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:10693764]" /experiment="EXISTENCE:mutant phenotype:GO:0097046 replication fork progression beyond termination site [PMID:20797631]" /note="DNA helicase involved in rDNA replication and Ty1 transposition; binds to and suppresses DNA damage at G4 motifs in vivo; relieves replication fork pauses at telomeric regions; deletion or inactivation of helicase function suppresses chromosome instability (CIN) associated with centromere or kinetochore defects; structurally and functionally related to Pif1p" /db_xref="GeneID:856426" /db_xref="SGD:S000001073" ORIGIN 1 mfrshasgnk kqwskrssng stpaasasgs hayrqqtlss ffmgcgkksa aasknsttii 61 dlesgdegnr nitapprprl irnnssslfs qsqgsfgddd pdaefkklvd vprlnsykks 121 srslsmtssl hktasasttq ktyhfdedet lrevtsvksn srqlsftsti niedssmkls 181 tdserpakrs kpsmefqglk ltvpkkikpl lrktvsnmds mnhrsasspv vltmeqervv 241 nlivkkrtnv fytgsagtgk svilqtiirq lsslygkesi aitastglaa vtiggstlhk 301 wsgigignkt idqlvkkiqs qkdllaawry tkvliideis mvdgnlldkl eqiarrirkn 361 ddpfggiqlv ltgdffqlpp vakkdehnvv kfcfesemwk rciqktillt kvfrqqdnkl 421 idilnairyg eltvdiakti rnlnrdidya dgiaptelya trrevelsnv kklqslpgdl 481 yefkavdnap eryqaildss lmvekvvalk edaqvmmlkn kpdvelvngs lgkvlffvte 541 slvvkmkeiy kivddevvmd mrlvsrvign pllkeskefr qdlnarplar lerlkiliny 601 avkisphkek fpyvrwtvgk nkyihelmvp erfpidipre nvglertqip lmlcwalsih 661 kaqgqtiqrl kvdlrrifea gqvyvalsra vtmdtlqvln fdpgkirtne rvkdfykrle 721 tlk // LOCUS NP_011897 581 aa linear PLN 30-JUN-2025 DEFINITION Erc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011897 VERSION NP_011897.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179162.1 REFERENCE 1 (residues 1 to 581) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 581) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 581) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 581) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06723. Method: conceptual translation. FEATURES Location/Qualifiers source 1..581 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..581 /product="Erc1p" /calculated_mol_wt="64078" Region 164..544 /region_name="MATE_eukaryotic" /note="Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; cd13132" /db_xref="CDD:240537" CDS 1..581 /gene="ERC1" /locus_tag="YHR032W" /coded_by="NM_001179162.1:1..1746" /experiment="EXISTENCE:mutant phenotype:GO:0006556 S-adenosylmethionine biosynthetic process [PMID:18592490]" /note="Member of the multi-drug and toxin extrusion (MATE) family; the MATE family is part of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine" /db_xref="GeneID:856427" /db_xref="SGD:S000001074" ORIGIN 1 mskqfshttn drrssiiyst svgkaglftp adyipqesee nliegeeqeg seeepsytgn 61 ddeteregey hslldannsr tlqqeawqqg ydshdrkrll deerdllidn kllsqhgngg 121 gdieshghgq aigpdeeerp aeiantwesa iesgqkistt fkretqvitm nalpliftfi 181 lqnslslasi fsvshlgtke lggvtlgsmt anitglaaiq glctcldtlc aqaygaknyh 241 lvgvlvqrca vitilaflpm myvwfvwsek ilalmipere lcalaanylr vtafgvpgfi 301 lfecgkrflq cqgifhasti vlfvcaplna lmnyllvwnd kigigylgap lsvvinywlm 361 tlglliyamt tkhkerplkc wngiipkeqa fknwrkminl aipgvvmvea eflgfevlti 421 fashlgtdal gaqsivatia slayqvpfsi svststrvan figaslydsc mitcrvslll 481 sfvcssmnmf vicrykeqia slfstesavv kmvvdtlpll afmqlfdafn astagclrgq 541 grqknrwvhq psrillprca hgicvsipvs sgcrrlmvgy n // LOCUS NP_011898 423 aa linear PLN 30-JUN-2025 DEFINITION putative glutamate 5-kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011898 VERSION NP_011898.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179163.1 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 423) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06724. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..423 /product="putative glutamate 5-kinase" /calculated_mol_wt="46733" Region 5..419 /region_name="proB" /note="glutamate 5-kinase; TIGR01027" /db_xref="CDD:162163" CDS 1..423 /locus_tag="YHR033W" /coded_by="NM_001179163.1:1..1272" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /note="hypothetical protein; epitope-tagged protein localizes to the cytoplasm; YHR033W has a paralog, PRO1, that arose from the whole genome duplication" /db_xref="GeneID:856428" /db_xref="SGD:S000001075" ORIGIN 1 mtkaytivik lgssslvdes tkepklsimt livetvtnlk rmghkviivs sggiavglda 61 lniphkpkql sevqaiaavg qgrliarwnm lfsqygeqta qilltrndil rwnqynnarn 121 tinellamgv ipivnendtl siseiefgdn dtlsaitaal vgadflfllt dvdclytdnp 181 rtnpdarpiv lvpelseglp gvntssgsgs evgtggmrtk liaadlasna gietivmksd 241 rpeyvpkivd yiqhhfrppr higngtqqqf ldlqdteleq lrrydvpmht kflandnkhk 301 lknrefwilh glitkgaiii densydklls kdmasltpna vievrdnfhe lecvdlkigq 361 rlpngeldis kpiqsvgcvr snytslelak ikglpsekih dvlgysvsey vahreniafp 421 pqf // LOCUS NP_011899 344 aa linear PLN 30-JUN-2025 DEFINITION Pih1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011899 VERSION NP_011899.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179164.1 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 344) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06725. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..344 /product="Pih1p" /calculated_mol_wt="39388" Region 32..165 /region_name="alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins." /note="The alpha-crystallin-Hsps_p23-like superfamily includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric...; cl00175" /db_xref="CDD:469641" Region 265..344 /region_name="Pih1_fungal_CS" /note="Fungal Pih1 CS domain; pfam18482" /db_xref="CDD:436535" CDS 1..344 /gene="PIH1" /locus_tag="YHR034C" /gene_synonym="NOP17" /coded_by="NM_001179164.1:1..1035" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0097255 R2TP complex [PMID:15766533]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:15670595]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:15766533]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:18268103]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:15670595]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15766533]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27053109]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:15766533]" /experiment="EXISTENCE:physical interaction:GO:0097255 R2TP complex [PMID:18268103]" /note="Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II" /db_xref="GeneID:856429" /db_xref="SGD:S000001076" ORIGIN 1 madfllrpik qrhrnedkyv svdaadgsvs kiepiadfvi ktkllsangp eklqdgrkvf 61 invchsplvp kpevdfnari vfpliiqnew eipiitscyr mdhdkkgqec yvwdccinsd 121 csrwicddiq lreilvewcl esceirdsvv lcrdriafpk mkkkgaelpa levlndelhq 181 dykakmhkii eeeagdpmsi lrgrnddgdd nndpddgtlp plfpienkis gakieeidkn 241 eiahrnlkqa papapapheq qedvpeyevk mkrfkgaayk lrilienkap nskpdrfsps 301 ynfaenilyi ngklsiplpr divvnaadik ifhirkertl yiyi // LOCUS NP_011900 630 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein NEL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011900 VERSION NP_011900.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179165.1 REFERENCE 1 (residues 1 to 630) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 630) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 630) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 630) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06726. Method: conceptual translation. FEATURES Location/Qualifiers source 1..630 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..630 /product="GTPase-activating protein NEL1" /calculated_mol_wt="72176" Region 1..630 /region_name="SEC23" /note="Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; COG5047" /db_xref="CDD:227380" CDS 1..630 /gene="NEL1" /locus_tag="YHR035W" /coded_by="NM_001179165.1:1..1893" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:24947508]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:24947508]" /note="Activator of Sar1p GTPase activity; paralog of Sec23 but does not associate with the COPII components; not an essential gene" /db_xref="GeneID:856430" /db_xref="SGD:S000001077" ORIGIN 1 mcsptnflye pfssdavtqn ydqnlkctkc gayysmacsl reqnvwtclf cnqsnsnael 61 plvpsntytl tsakkeilsr rtimiidaic dphelnylvs ilcnnyitrq qeplsiitiq 121 qsghvilhna vnhrrdavfs inefmtkynl dklnasyfek kiseinqesy wfdkstqgsl 181 rkllreicki ankvnisskr dkrctglalf vssvlasqcs lsaychivsf lngpctkggg 241 kvmsrerges mrqnhhfesk ssqlqlsksp tkfykkmlek fanqsliyef fiasldqigi 301 lemsplitss mavsqfdsfn derfamsfqk ylnlrdhnai ynchskimta knaivvkdfp 361 kyslnpknls lpleislghn saeapiqfqt tfenqtekyi rietlllpka nrsfgaqnei 421 vfsmkkiasr iidsfayssk htkelmkqlf llpnqirgkd vdmvnliqwc yhiyrspils 481 vrntspdery lflhriinas kdtclslckp fiwsysdlkh dwivldvplt raqilqddkt 541 ticvdggsyl vlrrgkllek egrelcckll ndlqrfpqpl yvetktggsq drflkskiip 601 lditdketlg tedmtfneyf nlftdlsgsk // LOCUS NP_011901 471 aa linear PLN 30-JUN-2025 DEFINITION Brl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011901 VERSION NP_011901.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179166.1 REFERENCE 1 (residues 1 to 471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 471) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06727. Method: conceptual translation. FEATURES Location/Qualifiers source 1..471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..471 /product="Brl1p" /calculated_mol_wt="53254" Region 174..445 /region_name="COG5085" /note="Predicted membrane protein [Function unknown]" /db_xref="CDD:227417" CDS 1..471 /gene="BRL1" /locus_tag="YHR036W" /coded_by="NM_001179166.1:1..1416" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15882446|PMID:26432634]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15882446|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15882446]" /experiment="EXISTENCE:genetic interaction:GO:0055088 lipid homeostasis [PMID:26432634]" /experiment="EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:15882446]" /experiment="EXISTENCE:mutant phenotype:GO:0055088 lipid homeostasis [PMID:26432634]" /note="Essential nuclear envelope/ER integral membrane protein; interacts and functions with Apq12p and Brr6p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, mRNA nuclear export and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; identified as a dosage suppressor of a temperature sensitive mutation in the major karyopherin, CRM1; homologous to Brr6p" /db_xref="GeneID:856431" /db_xref="SGD:S000001078" ORIGIN 1 mesfenlsir dsftsgmehv deelgglsdl siskqgptls pqlinrfmph fpsspsplrn 61 tldfsaakad eeeddrmeid evddtsfeee ynnepietht eatenavvee ieatpeerqk 121 qeknesqdqs veevenivsp hrstvikall sptdlgvaaa tkvegvvplp psanqddnes 181 snnnaegedi irneevedei ksslgnhkss qyanafdsei ikrelrsrsk yqpiqvsfnt 241 hnyfysdkdg iktysltkpn hnkidefydq neafklpkpw spnshpasra syalmsylql 301 flnaittvvi fsfilsfiia lqkdlkstwe qrkhelqyes ricqeqyltn rcnqtpglpa 361 lgeqcaiwkq cmdrnndiff rarstlsakl fgdiinsfid plnwktlfvi fcgvitwcfs 421 snfllgfvra ksyygngikt yplpsspksp tseethssmt asgedshllk q // LOCUS NP_011902 575 aa linear PLN 30-JUN-2025 DEFINITION 1-pyrroline-5-carboxylate dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011902 VERSION NP_011902.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179167.1 REFERENCE 1 (residues 1 to 575) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 575) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 575) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 575) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06728. Method: conceptual translation. FEATURES Location/Qualifiers source 1..575 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..575 /product="1-pyrroline-5-carboxylate dehydrogenase" /EC_number="1.2.1.88" /calculated_mol_wt="64304" Region 29..574 /region_name="D1pyr5carbox1" /note="delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; TIGR01236" /db_xref="CDD:273517" Site order(208..212,219,234,236..237,285..288,291,294..295, 317..319,351,458,460,488,531) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:143395" Site order(212,317,348,351) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:143395" CDS 1..575 /gene="PUT2" /locus_tag="YHR037W" /coded_by="NM_001179167.1:1..1728" /experiment="EXISTENCE:direct assay:GO:0003842 L-glutamate gamma-semialdehyde dehydrogenase activity [PMID:4145181]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:3025596]" /experiment="EXISTENCE:direct assay:GO:0006537 glutamate biosynthetic process [PMID:4145181]" /experiment="EXISTENCE:mutant phenotype:GO:0003842 L-glutamate gamma-semialdehyde dehydrogenase activity [PMID:387737]" /experiment="EXISTENCE:mutant phenotype:GO:0010133 L-proline catabolic process to L-glutamate [PMID:387737]" /note="Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant" /db_xref="GeneID:856432" /db_xref="SGD:S000001079" ORIGIN 1 mlsarclksi yfkrsfsqlg hikppkhirn epvkpfrnid lkdwdllras lmkfksssle 61 vplvingeri ydnneralfp qtnpanhqqv lanvtqatek dvmnavkaak dakkdwynlp 121 fydrsaiflk aadlistkyr ydmlaatmlg qgknvyqaei dcitelsdff ryyvkyasdl 181 yaqqpvesad gtwnkaeyrp legfvyavsp fnftaiaanl igapalmgnt vvwkpsqtaa 241 lsnyllmtvl eeaglpkgvi nfipgdpvqv tdqvladkdf galhftgstn vfkslygkiq 301 sgvvegkyrd ypriigetgg knfhlvhpsa nishavlsti rgtfefqgqk csaasrlylp 361 eskseeflsd mfgilqsqnv vpmntsaspi sggnlrgfmg pviheqsfdk lvkviedakk 421 dpeleilygg qydksqgwfv gptvikakrp dhpymsteff gpiltvyeyp dtefneicdi 481 idntsqyalt gaifakdrka ieyadeklkf sagnfyindk ctgavvsqqw fggarmsgtd 541 dkaggpnils rfvsirntke nfyeltdfky psnye // LOCUS NP_011903 230 aa linear PLN 30-JUN-2025 DEFINITION Rrf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011903 VERSION NP_011903.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179168.1 REFERENCE 1 (residues 1 to 230) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 230) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 230) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 230) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06729. Method: conceptual translation. FEATURES Location/Qualifiers source 1..230 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..230 /product="Rrf1p" /calculated_mol_wt="26276" Region 51..229 /region_name="RRF" /note="Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; cd00520" /db_xref="CDD:238288" Site order(75..78,148..151) /site_type="other" /note="hinge region" /db_xref="CDD:238288" CDS 1..230 /gene="RRF1" /locus_tag="YHR038W" /gene_synonym="FIL1; KIM4" /coded_by="NM_001179168.1:1..693" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961|PMID:12853640]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:12853640]" /note="Mitochondrial ribosome recycling factor; essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria" /db_xref="GeneID:856433" /db_xref="SGD:S000001080" ORIGIN 1 milttarlnc rpvtvprlfn rsfsqsfiil kkksstptek veedeidvne llkkaetqfk 61 ktleiqkqkm neikqgnfnp kvfnslvfkn nrkftdiatt slkgknalli tvfdpkdvkt 121 visgvlaanl nltpervpnn dlqlkvslpp pttesrlkva kdlkrvfeey kqsslkdslg 181 tirgsilkef ksfkkddavr kaerdleklh kdyvnklhdq fqkveksivk // LOCUS NP_011904 644 aa linear PLN 30-JUN-2025 DEFINITION meiotic recombination directing protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011904 VERSION NP_011904.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179169.1 REFERENCE 1 (residues 1 to 644) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 644) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 644) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 644) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06730. Method: conceptual translation. FEATURES Location/Qualifiers source 1..644 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..644 /product="meiotic recombination directing protein" /calculated_mol_wt="71190" Region 115..590 /region_name="ALDH_F15-22" /note="Aldehyde dehydrogenase family 15A1 and 22A1-like; cd07098" /db_xref="CDD:143416" Site order(244..248,256,271,273..274,330..333,336,339..340, 354..356,389,494,496,522,561) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:143416" Site order(248,354,386,389) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:143416" CDS 1..644 /gene="MSC7" /locus_tag="YHR039C" /coded_by="NM_001179169.1:1..1935" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511544]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids" /db_xref="GeneID:856434" /db_xref="SGD:S000001081" ORIGIN 1 mskvylnsdm inhlnstvqa yfnlwlekqn aimrsqpqii qdnqkligit tlvasiftly 61 vlvkiistpa kcsssykpvk fslpapeaaq nnwkgkrsvs tniwnpeepn fiqchcpatg 121 qylgsfpskt eadidemvsk agkaqstwgn sdfsrrlrvl aslhdyilnn qdliarvacr 181 dsgktmldas mgeilvtlek iqwtikhgqr alqpsrrpgp tnffmkwykg aeiryeplgv 241 issivswnyp fhnllgpiia alftgnaivv kcseqvvwss effvelirkc leacdedpdl 301 vqlcyclppt enddsanyft shpgfkhitf igsqpvahyi lkcaaksltp vvvelggkda 361 fivldsaknl dalssiimrg tfqssgqnci giervivske nyddlvkiln drmtanplrq 421 gsdidhlenv dmgamisdnr fdelealvkd avakgarllq ggsrfkhpky pqghyfqptl 481 lvdvtpemki aqnevfgpil vmmkakntdh cvqlansapf glggsvfgad ikecnyvans 541 lqtgnvaind fatfyvcqlp fggingsgyg kfggeegllg lcnaksvcfd tlpfvstqip 601 kpldypirnn akawnfvksf ivgaytnstw qrikslfsla keas // LOCUS NP_011905 114 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V1 sector ATPase subunit G [Saccharomyces cerevisiae S288C]. ACCESSION NP_011905 VERSION NP_011905.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180027.1 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 114) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06731. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..114 /product="H(+)-transporting V1 sector ATPase subunit G" /calculated_mol_wt="12582" Region 2..112 /region_name="V_ATP_synt_G" /note="vacuolar ATP synthase, subunit G; TIGR01147" /db_xref="CDD:130217" CDS 1..114 /gene="VMA10" /locus_tag="YHR039C-A" /gene_synonym="YHR039C-B" /coded_by="NM_001180027.1:1..345" /experiment="EXISTENCE:direct assay:GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain [PMID:16774922]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:22842922]" /note="Subunit G of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits" /db_xref="GeneID:856435" /db_xref="SGD:S000002100" ORIGIN 1 msqkngiatl lqaekeahei vskarkyrqd klkqaktdaa keidsykiqk dkelkefeqk 61 naggvgelek kaeagvqgel aeikkiaekk kddvvkilie tvikpsaevh inal // LOCUS NP_011906 366 aa linear PLN 30-JUN-2025 DEFINITION Bcd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011906 VERSION NP_011906.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179170.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 366) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06732. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..366 /product="Bcd1p" /calculated_mol_wt="42203" Region 4..42 /region_name="zf-HIT_BCD1" /note="zinc finger HIT (zf-HIT) found in Box C/D snoRNA protein 1 (BCD1) and similar proteins; cd23023" /db_xref="CDD:467795" Site order(5,8,17,20,25,29,33,39) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:467795" CDS 1..366 /gene="BCD1" /locus_tag="YHR040W" /coded_by="NM_001179170.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0000492 box C/D snoRNP assembly [PMID:31537647]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:31537647]" /experiment="EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:31537647]" /experiment="EXISTENCE:mutant phenotype:GO:0016074 sno(s)RNA metabolic process [PMID:12837249]" /note="Essential protein required for the accumulation of box C/D snoRNA" /db_xref="GeneID:856436" /db_xref="SGD:S000001082" ORIGIN 1 mavlcgvcgi kefkykcprc lvqtcslecs kkhktrdncs gqthdpkeyi ssealkqadd 61 dkhernayvq rdynyltqlk rmvhvqkmda rmknkrvlgp vgghnsnfkk rrydideddr 121 dstecqriir rgvnclmlpk gmqrssqnrs kwdktmdlfv wsvewilcpm qekgekkelf 181 khvshriket dflvqgmgkn vfqkccefyr lagtsscieg edgsetkeer tqilqksglk 241 fytktfpynt thimdskklv elaihekcig ellknttvie fptifvamte adlpegyevl 301 hqeprpleht stlnkfidna reeedaeeds qpteepvqke tqdasdsdsd sdddynpgls 361 mdflta // LOCUS NP_011907 210 aa linear PLN 30-JUN-2025 DEFINITION Srb2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011907 VERSION NP_011907.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179171.1 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 210) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06733. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..210 /product="Srb2p" /calculated_mol_wt="22763" Region 1..209 /region_name="Med20" /note="TATA-binding related factor (TRF) of subunit 20 of Mediator complex; pfam08612" /db_xref="CDD:400779" CDS 1..210 /gene="SRB2" /locus_tag="YHR041C" /gene_synonym="HRS2; MED20" /coded_by="NM_001179171.1:1..633" /experiment="EXISTENCE:direct assay:GO:0001094 TFIID-class transcription factor complex binding [PMID:1591782]" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:1591782]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8187178]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:1591782]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:genetic interaction:GO:0019904 protein domain specific binding [PMID:2693207]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15831453]" /experiment="EXISTENCE:mutant phenotype:GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:18604275]" /experiment="EXISTENCE:mutant phenotype:GO:0031669 cellular response to nutrient levels [PMID:18604275]" /experiment="EXISTENCE:mutant phenotype:GO:0070887 cellular response to chemical stimulus [PMID:18604275]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance" /db_xref="GeneID:856437" /db_xref="SGD:S000001083" ORIGIN 1 mgksavifve ratpatltel kdalsnsils vrdpwsidfr tyrcsiknlp advsklmysi 61 tfhhhgrqtv likdnsamvt taaaadippa lvfngsstgv pesidtilss klsniwmqrq 121 likgdagetl ildgltvrlv nlfsstgfkg llielqadea gefetkiagi eghlaeirak 181 eyktssdslg pdtsneicdl ayqyvralel // LOCUS NP_011908 691 aa linear PLN 30-JUN-2025 DEFINITION NADPH--hemoprotein reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011908 VERSION NP_011908.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179172.1 REFERENCE 1 (residues 1 to 691) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 691) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 691) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 691) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06734. Method: conceptual translation. FEATURES Location/Qualifiers source 1..691 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..691 /product="NADPH--hemoprotein reductase" /EC_number="1.6.2.4" /calculated_mol_wt="76641" Region 63..199 /region_name="Flavodoxin_1" /note="pfam00258" /db_xref="CDD:425562" Region 264..691 /region_name="CYPOR" /note="NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via...; cd06204" /db_xref="CDD:99801" Site order(285,459,461,542..543,580..581,610..611,617,619,621, 646,650,653) /site_type="other" /note="NADP binding pocket [chemical binding]" /db_xref="CDD:99801" Site order(306,439..442,457..459,476..479,691) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99801" Site order(439,441..442) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99801" Site order(442,644,689,691) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:99801" Site order(476,479,482) /site_type="other" /note="phosphate binding motif [ion binding]" /db_xref="CDD:99801" Site order(538,542..545,547) /site_type="other" /note="beta-alpha-beta structure motif" /db_xref="CDD:99801" CDS 1..691 /gene="NCP1" /locus_tag="YHR042W" /gene_synonym="CPR1" /coded_by="NM_001179172.1:1..2076" /experiment="EXISTENCE:direct assay:GO:0003958 NADPH-hemoprotein reductase activity [PMID:9087488]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0009055 electron transfer activity [PMID:11485306]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:9468503]" /note="NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p" /db_xref="GeneID:856438" /db_xref="SGD:S000001084" ORIGIN 1 mpfgidntdf tvlaglvlav llyvkrnsik ellmsddgdi tavssgnrdi aqvvtennkn 61 ylvlyasqtg taedyakkfs kelvakfnln vmcadvenyd feslndvpvi vsifistyge 121 gdfpdgavnf edficnaeag alsnlrynmf glgnstyeff ngaakkaekh lsaagairlg 181 klgeaddgag ttdedymawk dsilevlkde lhldeqeakf tsqfqytvln eitdsmslge 241 psahylpshq lnrnadgiql gpfdlsqpyi apivksrelf ssndrncihs efdlsgsnik 301 ystgdhlavw psnplekveq flsifnldpe tifdlkpldp tvkvpfptpt tigaaikhyl 361 eitgpvsrql fssliqfapn advkekltll skdkdqfave itskyfniad alkylsdgak 421 wdtvpmqflv esvpqmtpry ysisssslse kqtvhvtsiv enfpnpelpd appvvgvttn 481 llrniqlaqn nvniaetnlp vhydlngprk lfanyklpvh vrrsnfrlps npstpvimig 541 pgtgvapfrg firervafle sqkkggnnvs lgkhilfygs rntddflyqd ewpeyakkld 601 gsfemvvahs rlpntkkvyv qdklkdyedq vfeminngaf iyvcgdakgm akgvstalvg 661 ilsrgksitt deatelikml ktsgryqedv w // LOCUS NP_011909 246 aa linear PLN 30-JUN-2025 DEFINITION 2-deoxyglucose-6-phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011909 VERSION NP_011909.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179173.1 REFERENCE 1 (residues 1 to 246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 246) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06735. Method: conceptual translation. FEATURES Location/Qualifiers source 1..246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..246 /product="2-deoxyglucose-6-phosphatase" /EC_number="3.1.3.68" /calculated_mol_wt="27034" Region 9..231 /region_name="HAD_ScGPP-like" /note="subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p); cd07527" /db_xref="CDD:319829" Site order(12..16,47..48,117..119,151,182..183,186..187) /site_type="active" /db_xref="CDD:319829" CDS 1..246 /gene="DOG2" /locus_tag="YHR043C" /coded_by="NM_001179173.1:1..741" /experiment="EXISTENCE:direct assay:GO:0003850 2-deoxyglucose-6-phosphatase activity [PMID:8553694]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006006 glucose metabolic process [PMID:8553694]" /note="2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed; DOG2 has a paralog, DOG1, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae" /db_xref="GeneID:856439" /db_xref="SGD:S000001085" ORIGIN 1 mpqfsvdlcl fdldgtivst ttaaesawkk lcrqhgvdpv elfkhshgar sqemmkkffp 61 kldntdnkgv lalekdmadn yldtvslipg aenlllsldv dtetqkklpe rkwaivtsgs 121 pylafswfet ilknvgkpkv fitgfdvkng kpdpegysra rdllrqdlql tgkqdlkyvv 181 fedapvgika gkamgaitvg itssydksvl fdagadyvvc dltqvsvvkn nengiviqvn 241 npltrd // LOCUS NP_011910 246 aa linear PLN 30-JUN-2025 DEFINITION 2-deoxyglucose-6-phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011910 VERSION NP_011910.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179174.1 REFERENCE 1 (residues 1 to 246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 246) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06736. Method: conceptual translation. FEATURES Location/Qualifiers source 1..246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..246 /product="2-deoxyglucose-6-phosphatase" /EC_number="3.1.3.68" /calculated_mol_wt="26969" Region 9..231 /region_name="HAD_ScGPP-like" /note="subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p); cd07527" /db_xref="CDD:319829" Site order(12..16,47..48,117..119,151,182..183,186..187) /site_type="active" /db_xref="CDD:319829" CDS 1..246 /gene="DOG1" /locus_tag="YHR044C" /coded_by="NM_001179174.1:1..741" /experiment="EXISTENCE:direct assay:GO:0003850 2-deoxyglucose-6-phosphatase activity [PMID:8553694]" /experiment="EXISTENCE:direct assay:GO:0006006 glucose metabolic process [PMID:8553694]" /note="2-deoxyglucose-6-phosphate phosphatase; member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed; DOG1 has a paralog, DOG2, that arose from a single-locus duplication; the last half of DOG1 and DOG2 are subject to gene conversions among S. cerevisiae, S. paradoxus, and S. mikatae" /db_xref="GeneID:856440" /db_xref="SGD:S000001086" ORIGIN 1 maefsadlcl fdldgtivst tvaaekawtk lcyeygvdps elfkhshgar tqevlrrffp 61 klddtdnkgv lalekdiahs yldtvslipg aenlllsldv dtetqkklpe rkwaivtsgs 121 pylafswfet ilknvgkpkv fitgfdvkng kpdpegysra rdllrqdlql tgkqdlkyvv 181 fedapvgika gkamgaitvg itssydksvl fdagadyvvc dltqvsvvkn nengiviqvn 241 npltra // LOCUS NP_011911 560 aa linear PLN 30-JUN-2025 DEFINITION Dde1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011911 VERSION NP_011911.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179175.1 REFERENCE 1 (residues 1 to 560) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 560) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 560) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 560) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06737. Method: conceptual translation. FEATURES Location/Qualifiers source 1..560 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..560 /product="Dde1p" /calculated_mol_wt="62561" CDS 1..560 /gene="DDE1" /locus_tag="YHR045W" /coded_by="NM_001179175.1:1..1683" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /note="Protein involved in DNA damage response and ergosterol biosynthesis; acts in cooperation with Dap1p in regulating DNA damage response and ergosterol biosynthesis" /db_xref="GeneID:856441" /db_xref="SGD:S000001087" ORIGIN 1 mnwsfllqlv itillivlga nwllssflld fkrdltgval sqqssissvr kenetayyrs 61 ilvptgfplt tglglslkyk irngnfgdvw naimevskgk niikftgrek syslselngm 121 akrifpklsn knfknigian siatvegftl slasmmtsir tgsiphflpa vprqrledvd 181 vliidswksf kmlngsedwy klivvcddpi eslqfdancd vitwkelidg ftkdteyqyt 241 ppddnsddkk lfayvtspwn gtnsfnqicl vsniaefikg fplgnelnsn eyltistkla 301 nssaslqiwg klfavllhgg sasfinptti dceslqettl lftetkdvvk lidsnsrsgl 361 lnkiylswat nllsegiftk iariephsle klrcvyladn vkdaevistf pekipqlkkt 421 nrritpsteq lnkiraqlgs rvvlelycpy aimgpvahtn fydyrvfgks vddnvvcygt 481 lsttlegkmv etetnphlni ekkqgmlcir gfsigkpves drlekalhla erfgggegwm 541 plvgvfglfg qdgclyiynq // LOCUS NP_011912 295 aa linear PLN 30-JUN-2025 DEFINITION inositol monophosphate 1-phosphatase INM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011912 VERSION NP_011912.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179176.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 295) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06738. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..295 /product="inositol monophosphate 1-phosphatase INM1" /EC_number="3.1.3.25" /calculated_mol_wt="32692" Region 10..267 /region_name="IMPase" /note="inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be recycled...; cd01639" /db_xref="CDD:238817" Site order(37,44,50,73..74,92..97,230..231) /site_type="active" /db_xref="CDD:238817" Site order(43,45,98..99,101..106,164..166,168,170..171,180..181, 184,187..188,191,199..205,213,217..220) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:238817" CDS 1..295 /gene="INM1" /locus_tag="YHR046C" /coded_by="NM_001179176.1:1..888" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008934 inositol monophosphate 1-phosphatase activity [PMID:10096091]" /experiment="EXISTENCE:direct assay:GO:0071545 inositol phosphate catabolic process [PMID:10844654]" /experiment="EXISTENCE:genetic interaction:GO:0008934 inositol monophosphate 1-phosphatase activity [PMID:12593845]" /experiment="EXISTENCE:genetic interaction:GO:0071545 inositol phosphate catabolic process [PMID:12593845]" /note="Inositol monophosphatase; involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate" /db_xref="GeneID:856442" /db_xref="SGD:S000001088" ORIGIN 1 mtidlasiek flcelatekv gpiiksksgt qkdydlktgs rsvdivtaid kqvekliwes 61 vktqyptfkf igeesyvkge tvitddptfi idpidgttnf vhdfpfscts lgltvnkepv 121 vgviynphin llvsaskgng mrvnnkdydy ksklesmgsl ilnksvvalq pgsaregknf 181 qtkmatyekl lscdygfvhg frnlgssamt mayiamgyld sywdggcysw dvcagwcilk 241 evggrvvgan pgewsidvdn rtylavrgti nnesdeqtky itdfwncvdg hlkyd // LOCUS NP_011913 856 aa linear PLN 30-JUN-2025 DEFINITION arginine/alanine aminopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011913 VERSION NP_011913.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179177.1 REFERENCE 1 (residues 1 to 856) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 856) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 856) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 856) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 856) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 856) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 856) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06739. Method: conceptual translation. FEATURES Location/Qualifiers source 1..856 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..856 /product="arginine/alanine aminopeptidase" /calculated_mol_wt="97532" Region 13..447 /region_name="M1_APN-Q_like" /note="Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1); cd09601" /db_xref="CDD:341064" Site order(130,132,264..267,300..301,304,323,327,381,386) /site_type="active" /db_xref="CDD:341064" Region 517..833 /region_name="ERAP1_C" /note="ERAP1-like C-terminal domain; pfam11838" /db_xref="CDD:463368" CDS 1..856 /gene="AAP1" /locus_tag="YHR047C" /gene_synonym="AAP1'" /coded_by="NM_001179177.1:1..2571" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004177 aminopeptidase activity [PMID:8100228]" /experiment="EXISTENCE:mutant phenotype:GO:0005977 glycogen metabolic process [PMID:8100228]" /experiment="EXISTENCE:mutant phenotype:GO:0006508 proteolysis [PMID:8100228]" /note="Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication" /db_xref="GeneID:856443" /db_xref="SGD:S000001089" ORIGIN 1 msrevlpnnv tplhyditle pnfraftfeg slkidlqind hsinsvqiny leidfhsari 61 egvnaievnk nenqqkatlv fpngtfenlg psakleiifs gilndqmagf yrakytdkvt 121 getkymattq meatdarraf pcfdepnlka tfavtlvses flthlsnmdv rnetikegkk 181 yttfnttpkm stylvafiva dlryvesnnf ripvrvystp gdekfgqfaa nlaartlrff 241 edtfnieypl pkmdmvavhe fsagamenwg lvtyrvidll ldienssldr iqrvaeviqh 301 elahqwfgnl vtmdwweglw lnegfatwms wyscnkfqpe wkvweqyvtd nlqralnlds 361 lrsshpievp vnnadeinqi fdaisyskgs sllrmiskwl geetfikgvs qylnkfkygn 421 aktgdlwdal adasgkdvcs vmniwtkrvg fpvlsvkehk nkitltqhry lstgdvkeee 481 dttiypilla lkdstgidnt lvlneksatf elkneeffki ngdqsgifit sysderwakl 541 skqanllsve drvglvadak alsasgytst tnflnlisnw knedsfvvwe qiinslsalk 601 stwvfepedi lnaldkftld lvlnklselg wnigeddsfa iqrlkvtlfs aactsgnekm 661 qsiavemfee yangnkqaip alfkavvfnt varlggenny ekifniyqnp vsseekiial 721 ralgrfedke llertlsyll dgtvlnqdfy ipmqgirvhk kgierlwawm qehwdeiakr 781 lqpgspvlgg vltlgltnft sfealekisa fysrkvtkgf dqtlaqaldt irskaqwvsr 841 dreivatylr eheydq // LOCUS NP_011914 514 aa linear PLN 30-JUN-2025 DEFINITION Yhk8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011914 VERSION NP_011914.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179178.1 REFERENCE 1 (residues 1 to 514) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 514) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 514) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 514) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06740. Method: conceptual translation. FEATURES Location/Qualifiers source 1..514 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..514 /product="Yhk8p" /calculated_mol_wt="57707" Region 77..505 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(86..87,90..91,94,126,176..177,179..181,184,204, 207..208,211,314,317..318,321..323,326,350,354,425..426, 430,434,449,452..453,456..457,460) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..514 /gene="YHK8" /locus_tag="YHR048W" /coded_by="NM_001179178.1:1..1545" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles" /db_xref="GeneID:856444" /db_xref="SGD:S000001090" ORIGIN 1 mvaefqiasa qssaltstee ehcsinsdka akldleltse rkndgkqshe vtfnediadp 61 ediarhmsta rryyisslit ftsmvitmis sswtlpsthi iehfhishev stlgitlyvf 121 glgigplfls plselygrri tflyaltlsi iwqcltiwsk titgvmfgrf lsgffgsafl 181 svaggaiadi fdkdqigipm aiyttsaflg pslgpiigga lyhqsykwtf itllitsgcc 241 lvmiiftipe tykpmllirk akrlrkeknd qryyavlevt reqtsllsai flstkrpfgl 301 llrdrmmgvl cfytglelai iylyfvafpy vfkklynfgp meiacsyigi mvgmilsapt 361 cllfqktfew rvkrnngvkt pemrfeplfy gafltpvglf ifaftcykhv hwiapiigsa 421 ifgsgvyfvf tgvfaytvda yrryaasgma cntfvrcima gvfplfglqm yksmgvnwag 481 fllamvtvam ipvpflftky garlrakspy awdd // LOCUS NP_011915 243 aa linear PLN 30-JUN-2025 DEFINITION putative serine hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011915 VERSION NP_011915.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179179.1 REFERENCE 1 (residues 1 to 243) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 243) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 243) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 243) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06741. Method: conceptual translation. FEATURES Location/Qualifiers source 1..243 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..243 /product="putative serine hydrolase" /calculated_mol_wt="27208" Region 6..229 /region_name="FSH1" /note="Serine hydrolase (FSH1); pfam03959" /db_xref="CDD:461110" CDS 1..243 /gene="FSH1" /locus_tag="YHR049W" /coded_by="NM_001179179.1:1..732" /experiment="EXISTENCE:direct assay:GO:0004622 phosphatidylcholine lysophospholipase activity [PMID:32920715]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016788 hydrolase activity, acting on ester bonds [PMID:32182256]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:31363875]" /note="Lysophospholipase; hydrolyzes lysophosphatidylserine to release free fatty acid; involved in regulated cell death; localizes to both the nucleus and cytoplasm; contains a catalytic triad of Ser-His-Asp that is part of an alpha/beta hydrolase fold and a lipase motif (GXSXG); sequence similarity to Fsh2p and Fsh3p and the human candidate tumor suppressor and serine hydrolase, OVCA2" /db_xref="GeneID:856445" /db_xref="SGD:S000001091" ORIGIN 1 mtvqipkllf lhgflqngkv fsekssgirk llkkanvqcd yidapvllek kdlpfemdde 61 kwqatldadv nrawfyhsei sheldisegl ksvvdhikan gpydgivgfs qgaalssiit 121 nkiselvpdh pqfkvsvvis gysftepdpe hpgelritek frdsfavkpd mktkmifiyg 181 asdqavpsvr skylydiylk aqngnkekvl ayehpgghmv pnkkdiirpi veqitsslqe 241 ase // LOCUS NP_011917 549 aa linear PLN 30-JUN-2025 DEFINITION divalent metal ion transporter SMF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011917 VERSION NP_011917.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179180.1 REFERENCE 1 (residues 1 to 549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 549) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06742. Method: conceptual translation. FEATURES Location/Qualifiers source 1..549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..549 /product="divalent metal ion transporter SMF2" /calculated_mol_wt="59637" Region 55..458 /region_name="nramp" /note="NRAMP (natural resistance-associated macrophage protein) metal ion transporters; TIGR01197" /db_xref="CDD:162246" CDS 1..549 /gene="SMF2" /locus_tag="YHR050W" /coded_by="NM_001179180.1:1..1650" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:25713143]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:25713143]" /experiment="EXISTENCE:direct assay:GO:0022890 inorganic cation transmembrane transporter activity [PMID:10574989]" /experiment="EXISTENCE:genetic interaction:GO:0006824 cobalt ion transport [PMID:9115231]" /experiment="EXISTENCE:genetic interaction:GO:0006877 intracellular cobalt ion homeostasis [PMID:9115231]" /experiment="EXISTENCE:mutant phenotype:GO:0006828 manganese ion transport [PMID:11602606]" /experiment="EXISTENCE:mutant phenotype:GO:0030026 intracellular manganese ion homeostasis [PMID:11602606]" /note="Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins" /db_xref="GeneID:856447" /db_xref="SGD:S000001092" ORIGIN 1 mtsqeyepiq wsdesqtnnd svndayadvn tthesrrrtt lqpnstsqsm igtlrkyarf 61 igpglmvsvs ymdpgnysta vaagsahryk llfsvlvsnf maafwqylca rlgavtgldl 121 aqnckkhlpf glnitlyila emaiiatdla evvgtaisln ilfhiplalg viltvvdvli 181 vllaykpngs mkgirifeaf vsllvvltvv cftvelfyak lgpakeifsg flpskavfeg 241 dglylslail gatvmphsly lgsgvvqprl reydiknghy lpdandmdnn hdnyrpsyea 301 isetlhftit ellislftva lfvncailiv sgatlygstq naeeadlfsi ynllcstlsk 361 gagtvfvlal lfsgqsagiv ctlsgqmvse gflnwtvspa lrrsatrava itpclilvlv 421 agrsglsgal nasqvvlsll lpfvsaplly ftsskkimrv qlnrtkelsr ttdkkpvadr 481 teddetiele emgigsssqe rslvspapey kdmsngmivt vlaiivwlii sglnfymllg 541 fttgkevhl // LOCUS NP_878088 56 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR050W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878088 VERSION NP_878088.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184652.1 REFERENCE 1 (residues 1 to 56) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 56) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 56) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 56) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06743. Method: conceptual translation. FEATURES Location/Qualifiers source 1..56 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..56 /product="uncharacterized protein" /calculated_mol_wt="6447" CDS 1..56 /locus_tag="YHR050W-A" /coded_by="NM_001184652.1:1..171" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466528" /db_xref="SGD:S000028832" ORIGIN 1 mkrdligpvk alikinncsc lsrcqisrlp hfftfhphfs tliyyynlkn citset // LOCUS NP_011918 148 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c oxidase subunit VI [Saccharomyces cerevisiae S288C]. ACCESSION NP_011918 VERSION NP_011918.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179181.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 148) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06744. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..148 /product="cytochrome c oxidase subunit VI" /calculated_mol_wt="17210" Region 49..145 /region_name="COX5A" /note="Cytochrome c oxidase subunit Va; pfam02284" /db_xref="CDD:460522" Site order(49,52..53,80..84,117,120,123,126) /site_type="other" /note="Subunit Va/VIc interface [polypeptide binding]" /db_xref="CDD:238463" Site order(67,71) /site_type="other" /note="Subunit Va/Vb interface [polypeptide binding]" /db_xref="CDD:238463" Site order(70,74,96,99..103,106,109..110,113,136,138,145) /site_type="other" /note="Subunit Va/IV interface [polypeptide binding]" /db_xref="CDD:238463" Site order(78,80,114) /site_type="other" /note="Subunit Va/II interface [polypeptide binding]" /db_xref="CDD:238463" CDS 1..148 /gene="COX6" /locus_tag="YHR051W" /coded_by="NM_001179181.1:1..447" /experiment="EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:1331058|PMID:7851399]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0045277 respiratory chain complex IV [PMID:1331058]" /note="Subunit VI of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels" /db_xref="GeneID:856448" /db_xref="SGD:S000001093" ORIGIN 1 mlsraifrnp vinrtllrar pgayhatrlt kntfiqsrky sdahdeetfe eftaryekef 61 deaydlfevq rvlnncfsyd lvpapaviek alraarrvnd lptairvfea lkykvenedq 121 ykayldelkd vrqelgvplk eelfpsss // LOCUS NP_011919 376 aa linear PLN 30-JUN-2025 DEFINITION Cic1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011919 VERSION NP_011919.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179182.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 376) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06745. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..376 /product="Cic1p" /calculated_mol_wt="42399" Region 77..287 /region_name="Ribosomal_L1" /note="Ribosomal protein L1p/L10e family; pfam00687" /db_xref="CDD:459905" CDS 1..376 /gene="CIC1" /locus_tag="YHR052W" /gene_synonym="NSA3" /coded_by="NM_001179182.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11500370]" /experiment="EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0030163 protein catabolic process [PMID:11500370]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:11583614]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:11500370]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:11500370]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:11500370]" /note="Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles" /db_xref="GeneID:856449" /db_xref="SGD:S000001094" ORIGIN 1 makksnskks tpvstpskek kkviekksst aiprervika vnelikftsk pqdenneegn 61 ngkknlledd eeelkkdlql ivvnnksftg tsksfklkll nvkhsfykpw keasatavkd 121 fkvllilkds dikkvseddl fdqldsegik vdeiicgkdl ktvykayear nafisqfsli 181 laddsivtsl pklmggkayn kvettpisir thankefslt tltnnikkvy mnqlpvklpr 241 gttlnvhlgn lewlrpeefv dnveliseql ikayqirsif iktnrspvlp lyynqdvlde 301 leakkdkiee theddmvtid gvqvhlstfn kglmeianps elgsifskqi nnakkrssse 361 lekessesea vkkaks // LOCUS NP_001381960 57 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR052C-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381960 VERSION NP_001381960.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395031.1 REFERENCE 1 (residues 1 to 57) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 57) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 57) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 57) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54801. Method: conceptual translation. FEATURES Location/Qualifiers source 1..57 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..57 /product="uncharacterized protein" /calculated_mol_wt="5741" CDS 1..57 /locus_tag="YHR052C-B" /coded_by="NM_001395031.1:1..174" /note="Novel ORF identified by enrichment-based proteomics" /db_xref="GeneID:65052908" /db_xref="SGD:S000303807" ORIGIN 1 mkvmsananv vaakimnnak nhvaaqrgvt attnapavts lkkprshaal gnetnsl // LOCUS NP_011922 61 aa linear PLN 30-JUN-2025 DEFINITION metallothionein CUP1-1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011922 VERSION NP_011922.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179185.1 REFERENCE 1 (residues 1 to 61) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 61) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 61) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 61) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06748. Method: conceptual translation. FEATURES Location/Qualifiers source 1..61 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..61 /product="metallothionein CUP1-1" /calculated_mol_wt="6519" Region 9..47 /region_name="Yeast_MT" /note="Yeast metallothionein; pfam11403" /db_xref="CDD:463269" CDS 1..61 /gene="CUP1-1" /locus_tag="YHR053C" /gene_synonym="CUP1" /coded_by="NM_001179185.1:1..186" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:3902832]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:36503220]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:3308865|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016209 antioxidant activity [PMID:8367458]" /experiment="EXISTENCE:direct assay:GO:0019430 removal of superoxide radicals [PMID:8367458]" /experiment="EXISTENCE:direct assay:GO:0046870 cadmium ion binding [PMID:3902832]" /experiment="EXISTENCE:genetic interaction:GO:0016209 antioxidant activity [PMID:8367458]" /experiment="EXISTENCE:genetic interaction:GO:0019430 removal of superoxide radicals [PMID:8367458]" /experiment="EXISTENCE:mutant phenotype:GO:0004784 superoxide dismutase activity [PMID:8367458]" /experiment="EXISTENCE:mutant phenotype:GO:0010273 detoxification of copper ion [PMID:3536930]" /experiment="EXISTENCE:mutant phenotype:GO:0046688 response to copper ion [PMID:6370791]" /experiment="EXISTENCE:mutant phenotype:GO:0071585 detoxification of cadmium ion [PMID:3536930]" /note="Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-1 has a paralog, CUP1-2, that arose from a segmental duplication" /db_xref="GeneID:856450" /db_xref="SGD:S000001095" ORIGIN 1 mfselinfqn eghecqcqcg scknneqcqk scscptgcns ddkcpcgnks eetkksccsg 61 k // LOCUS NP_011921 354 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR054C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011921 VERSION NP_011921.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179184.1 REFERENCE 1 (residues 1 to 354) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 354) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 354) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 354) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06747. Method: conceptual translation. FEATURES Location/Qualifiers source 1..354 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..354 /product="uncharacterized protein" /calculated_mol_wt="40930" CDS 1..354 /locus_tag="YHR054C" /coded_by="NM_001179184.1:1..1065" /note="hypothetical protein; partial duplicate of RSC30/YHR056C, truncated remnant of segmental duplication" /db_xref="GeneID:856451" /db_xref="SGD:S000001096" ORIGIN 1 mvpaaenlsp ipasidtndi pliandlkll etqaklinil qgvpfylpvn ltkiesllet 61 ltmgvsntvd lyfhdnevrk ewkdtlnfin tivytnfflf vqnesslsma vqhssnnnkt 121 snsercakdl mkiisnmhif ysitfnfifp iksiksfssg nnrfhsngke flfanhfiei 181 lqnfiaitfa ifqrcevily defyknlsne einvqlllih dkileilkki eiivsflrde 241 mnsngsfksi kgfnkvlnli kymlrfskkk qnfarnsdnn nvtdysqsak nknvllkfpv 301 selnriylkf keisdflmer evvqrsiiid kdlesdnlgi ttanfndfyd afyn // LOCUS NP_001381961 57 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR054C-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381961 VERSION NP_001381961.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395032.1 REFERENCE 1 (residues 1 to 57) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 57) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 57) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 57) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54802. Method: conceptual translation. FEATURES Location/Qualifiers source 1..57 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..57 /product="uncharacterized protein" /calculated_mol_wt="5741" CDS 1..57 /locus_tag="YHR054C-B" /coded_by="NM_001395032.1:1..174" /note="Novel ORF identified by enrichment-based proteomics" /db_xref="GeneID:65052909" /db_xref="SGD:S000303808" ORIGIN 1 mkvmsananv vaakimnnak nhvaaqrgvt attnapavts lkkprshaal gnetnsl // LOCUS NP_011920 61 aa linear PLN 30-JUN-2025 DEFINITION metallothionein CUP1-2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011920 VERSION NP_011920.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179183.1 REFERENCE 1 (residues 1 to 61) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 61) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 61) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 61) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06746. Method: conceptual translation. FEATURES Location/Qualifiers source 1..61 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..61 /product="metallothionein CUP1-2" /calculated_mol_wt="6519" Region 9..47 /region_name="Yeast_MT" /note="Yeast metallothionein; pfam11403" /db_xref="CDD:463269" CDS 1..61 /gene="CUP1-2" /locus_tag="YHR055C" /gene_synonym="CUP1" /coded_by="NM_001179183.1:1..186" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:3902832]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:36503220]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:3308865]" /experiment="EXISTENCE:direct assay:GO:0016209 antioxidant activity [PMID:8367458]" /experiment="EXISTENCE:direct assay:GO:0019430 removal of superoxide radicals [PMID:8367458]" /experiment="EXISTENCE:direct assay:GO:0046870 cadmium ion binding [PMID:3902832]" /experiment="EXISTENCE:genetic interaction:GO:0016209 antioxidant activity [PMID:8367458]" /experiment="EXISTENCE:genetic interaction:GO:0019430 removal of superoxide radicals [PMID:8367458]" /experiment="EXISTENCE:mutant phenotype:GO:0004784 superoxide dismutase activity [PMID:8367458]" /experiment="EXISTENCE:mutant phenotype:GO:0010273 detoxification of copper ion [PMID:3536930]" /experiment="EXISTENCE:mutant phenotype:GO:0046688 response to copper ion [PMID:6370791]" /experiment="EXISTENCE:mutant phenotype:GO:0071585 detoxification of cadmium ion [PMID:3536930]" /note="Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-2 has a paralog, CUP1-1, that arose from a segmental duplication" /db_xref="GeneID:856452" /db_xref="SGD:S000001097" ORIGIN 1 mfselinfqn eghecqcqcg scknneqcqk scscptgcns ddkcpcgnks eetkksccsg 61 k // LOCUS NP_011923 883 aa linear PLN 30-JUN-2025 DEFINITION Rsc30p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011923 VERSION NP_011923.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179186.2 REFERENCE 1 (residues 1 to 883) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 883) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 883) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 883) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 883) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 883) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 883) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06749. On Feb 2, 2004 this sequence version replaced NP_011923.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..883 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..883 /product="Rsc30p" /calculated_mol_wt="101204" Region 9..47 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(10,14,19..22,24,27,37) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(15,18,25,32,35,43) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..883 /gene="RSC30" /locus_tag="YHR056C" /coded_by="NM_001179186.2:1..2652" /experiment="EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15870268]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:32188943]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:32188943|PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:32188943]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15870268]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11336698]" /note="Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; null mutants are osmosensitive; RSC30 has a paralog, RSC3, that arose from the whole genome duplication" /db_xref="GeneID:856453" /db_xref="SGD:S000001098" ORIGIN 1 mmdmqvrkvr kppactqcrk rkigcdrakp icgncvkynk pdcfypdgpg kmvavpsasg 61 msthgngqgs nhfsqgngvn qknvmiqtqy pimqtsieaf nfsfnpsvdt amqwtkaasy 121 qnnntnnnta prqnsstvss nvhgntivrs dspdvpsmdq ireyntrlql vnaqsfdytd 181 npysfnvgin qdsavfdlmt spftqeevli keidflknkl ldlqslqlks lkeksnlnad 241 nttankinkt genskkgkvd gkragfdhqt srtsqssqky ftaltitdvq slvqvkplkd 301 tpnylftknf iifrdhylfk fynilhdich inqfkvsppn nknhqqymev ckvnfppkai 361 iietlnsesl nnlnieeflp ifdktlllef vhnsfpngdt cpsfstvdlp lsqltklgel 421 tvlllllnds mtlfnkqain nhvsalmnnl rlirsqitli nleyydqeti kfiaitkfye 481 slymhddhks sldedlscll sfqikdfklf hflkkmyysr hsllgqssfm vpaaenlspi 541 pasidtndip liandlklle tqaklinilq gvpfylpvnl tkieslletl tmgvsntvdl 601 yfhdnevrke wkdtlnfint ivytnfflfv qnesslsmav qhssnnnkts nsercakdlm 661 kiisnmhify sitfnfifpi ksiksfssgn nrfhsngkef lfanhfieil qnfiaitfai 721 fqrcevilyd efyknlsnee invqlllihd kileilkkie iivsflrdem nsngsfksik 781 gfnkvlnlik ymlrfskkkq nfarnsdnnn vtdysqsakn knvllkfpvs elnriylkfk 841 eisdflmere vvqrsiiidk dlesdnlgit tanfndfyda fyn // LOCUS NP_011924 205 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase CPR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011924 VERSION NP_011924.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179187.1 REFERENCE 1 (residues 1 to 205) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 205) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 205) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 205) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06750. Method: conceptual translation. FEATURES Location/Qualifiers source 1..205 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..205 /product="peptidylprolyl isomerase CPR2" /EC_number="5.2.1.8" /calculated_mol_wt="22638" Region 37..197 /region_name="cyclophilin" /note="cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug...; cl00197" /db_xref="CDD:469651" Site order(88,90,93..94,96,134..135,144,146,155..156,160) /site_type="active" /db_xref="CDD:238194" CDS 1..205 /gene="CPR2" /locus_tag="YHR057C" /gene_synonym="CYP2" /coded_by="NM_001179187.1:1..618" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:1761234]" /note="Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; seamless-GFP and mCherry fusion proteins localize to the vacuole, while SWAT-GFP fusion localizes to both the endoplasmic reticulum and vacuole; suppresses toxicity of slow-folding human Z-type alpha1-antitrypsin variant associated with liver cirrhosis and emphysema" /db_xref="GeneID:856454" /db_xref="SGD:S000001099" ORIGIN 1 mkfsglwcwl llflsvnvia sdvgelidqd devitqkvff diehgeekvg riviglygkv 61 cpktaknfyk lstttnskkg figstfhrvi pnfmvqggdf tdgtgvggks iygdtfpden 121 ftlkhdrkgr lsmanrgkdt ngsqffittt eeaswldgkh vvfgqvvdgm dvvnyiqhvs 181 rdandkplea vkiakcgewt pelss // LOCUS NP_011925 295 aa linear PLN 30-JUN-2025 DEFINITION mediator complex subunit MED6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011925 VERSION NP_011925.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179188.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 295) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06751. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..295 /product="mediator complex subunit MED6" /calculated_mol_wt="32688" Region 1..283 /region_name="MED6" /note="RNA polymerase II transcriptional regulation mediator [Transcription]; COG5097" /db_xref="CDD:227428" CDS 1..295 /gene="MED6" /locus_tag="YHR058C" /coded_by="NM_001179188.1:1..888" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:9234719]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9234719]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:9234719]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9234719]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856455" /db_xref="SGD:S000001100" ORIGIN 1 mnvtpldelq wkspewiqvf glrtenvldy faespffdkt snnqvikmqr qfsqlndpna 61 avnmtqnimt lpdgkngnle eefayvdpar rqilfkypmy mqleeelmkl dgteyvlssv 121 repdfwvirk qrrtnnsgvg sakgpeiipl qdyyiigani yqsptifkiv qsrlmstsyh 181 lnstleslyd liefqpsqgv hykvptdtst tataatngnn agggsnkssv rptgganmat 241 vpsttnvnmt vntmgtggqt idngtgrtgn gnmgitteml dklmvtsirs tpnyi // LOCUS NP_011926 130 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS41 FYV4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011926 VERSION NP_011926.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179189.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 130) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06752. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..130 /product="mitochondrial 37S ribosomal protein mS41 FYV4" /calculated_mol_wt="15161" Region 43..96 /region_name="IGR" /note="IGR protein motif; pfam09597" /db_xref="CDD:462835" CDS 1..130 /gene="FYV4" /locus_tag="YHR059W" /gene_synonym="mS41" /coded_by="NM_001179189.1:1..393" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]" /note="hypothetical protein; required for survival upon exposure to K1 killer toxin" /db_xref="GeneID:856456" /db_xref="SGD:S000001101" ORIGIN 1 mipsrishkf plflrsslaa pkaayrfsst ipkpsdqvpd vdaflnkigr ncnelkdtfe 61 nnwnnlfqwd skilkekgvn iqqrkyilkq vhnyrnnrpi heiklgkksf fggerkrkaf 121 takwkaenkq // LOCUS NP_011927 181 aa linear PLN 30-JUN-2025 DEFINITION Vma22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011927 VERSION NP_011927.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179190.1 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 181) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06753. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..181 /product="Vma22p" /calculated_mol_wt="20947" CDS 1..181 /gene="VMA22" /locus_tag="YHR060W" /gene_synonym="CEV1; VPH6" /coded_by="NM_001179190.1:1..546" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:1628805]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:7673216|PMID:8582630]" /experiment="EXISTENCE:mutant phenotype:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:7673216]" /experiment="EXISTENCE:physical interaction:GO:1990871 Vma12-Vma22 assembly complex [PMID:9660861]" /note="Protein that is required for vacuolar H+-ATPase (V-ATPase) function; peripheral membrane protein; not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)" /db_xref="GeneID:856457" /db_xref="SGD:S000001102" ORIGIN 1 msetrmaqnm dttdeqylrl iellsnydst leqlqkgfqd gyiqlsrsny ynkdslrgny 61 gedywdetyi gqlmatveek nskvvveivk rkaqdkqekk eeednkltqr kkgtkpekqk 121 tqshklkqdy dpilmfggvl svpsslrqsq tsfkgcipli aqlinyknei ltlvetlseq 181 e // LOCUS NP_011928 314 aa linear PLN 30-JUN-2025 DEFINITION Gic1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011928 VERSION NP_011928.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179191.1 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 314) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06754. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..314 /product="Gic1p" /calculated_mol_wt="35107" Region 124..162 /region_name="CRIB" /note="PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the...; cd00132" /db_xref="CDD:238077" Site order(126,129,132,134,137,156,160) /site_type="other" /note="GTPase interaction site [polypeptide binding]" /db_xref="CDD:238077" CDS 1..314 /gene="GIC1" /locus_tag="YHR061C" /coded_by="NM_001179191.1:1..945" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9367980|PMID:9367979]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:9367979|PMID:9367980|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9367979]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9367980]" /experiment="EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:9367980]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:16371506]" /experiment="EXISTENCE:genetic interaction:GO:0032488 Cdc42 protein signal transduction [PMID:9367979]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:14734533]" /experiment="EXISTENCE:physical interaction:GO:0031106 septin ring organization [PMID:16371506]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:9367980|PMID:9367979]" /note="Rho-family GTPase interacting protein and Cdc42p effector; required with Gic2p for polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit; relocalizes from bud neck to nucleus upon DNA replication stress" /db_xref="GeneID:856458" /db_xref="SGD:S000001103" ORIGIN 1 mtegkrlqqm elpqmksiwi dedqemekly gfqvrqrfmn gpstdsdeda dedlgivlvd 61 skklalpnkn niklpplpny mtinpninsn hksltnkkkn flgmfkkkdl lsrrhgsakt 121 akqssistpf dfhhishang krednplesh eekhdveslv kftslapqpr pdsnvsskys 181 nvvmndssri vssstiattm dshhdgnetn ntpngnkqld sptdlemtle dlrnytfpsv 241 lgdsvsektn psspsvssfs gkfkprelsa lhtpelgncf nvdqslnspg nrisvddvlk 301 fyyqcsetst prnt // LOCUS NP_011929 293 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding RNA processing protein RPP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011929 VERSION NP_011929.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179192.1 REFERENCE 1 (residues 1 to 293) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 293) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 293) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 293) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06755. Method: conceptual translation. FEATURES Location/Qualifiers source 1..293 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..293 /product="RNA-binding RNA processing protein RPP1" /EC_number="3.1.26.5" /calculated_mol_wt="32093" Region 3..227 /region_name="RNase_P_p30" /note="RNase P subunit p30; pfam01876" /db_xref="CDD:396447" CDS 1..293 /gene="RPP1" /locus_tag="YHR062C" /coded_by="NM_001179192.1:1..882" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:23700311]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:9353260|PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9620854|PMID:9353260]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9353260|PMID:9620854]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9620854|PMID:9353260]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380|PMID:9353260]" /experiment="EXISTENCE:physical interaction:GO:0005655 nucleolar ribonuclease P complex [PMID:9353260]" /note="Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:856459" /db_xref="SGD:S000001104" ORIGIN 1 mlvdlnvpwp qnsyadkvts qavnnliktl stlhmlgyth iainftvnhs ekfpndvkll 61 npidikrrfg elmdrtglkl ysritliidd pskgqslski sqafdivaal pisekgltls 121 ttnldidllt fqygsrlptf lkhksicscv nrgvkleivy gyalrdvqar rqfvsnvrsv 181 irssrsrgiv igsgamsple crnilgvtsl iknlglpsdr cskamgdlas lvllngrlrn 241 kshkqtivtg ggsgngddvv ndvqgiddvq tikvvkrsmd aeqlghaskr hkp // LOCUS NP_011930 379 aa linear PLN 30-JUN-2025 DEFINITION 2-dehydropantoate 2-reductase PAN5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011930 VERSION NP_011930.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179193.1 REFERENCE 1 (residues 1 to 379) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 379) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 379) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 379) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06756. Method: conceptual translation. FEATURES Location/Qualifiers source 1..379 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..379 /product="2-dehydropantoate 2-reductase PAN5" /EC_number="1.1.1.169" /calculated_mol_wt="42690" Region 16..369 /region_name="apbA_panE" /note="2-dehydropantoate 2-reductase; TIGR00745" /db_xref="CDD:273247" CDS 1..379 /gene="PAN5" /locus_tag="YHR063C" /coded_by="NM_001179193.1:1..1140" /experiment="EXISTENCE:curator inference:GO:0015940 pantothenate biosynthetic process [PMID:11154694]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE" /db_xref="GeneID:856460" /db_xref="SGD:S000001105" ORIGIN 1 mtaphrstih ilglgamgtv lavdllrftn alvvplfrsq erlaqfqktn gnnisirkly 61 legspifsyp vekcecpetf skkpidnlvv ttktyqtkea lapylpyink ntnliliqng 121 lgvlellree iftdsknrph lfqgvishgv yqdkagvfnh agwagmkiak lpwteeemiq 181 kksvveddaa nnslvkllte pkfakefgie hstyqemlfg qlfkflvnac mnpvtaildc 241 vngemkascg pvftsiidec lqilrvayrp lfqyhekysg neeypemdvn avlttdnmvs 301 evtrigcdin srnsssmrqd tlflrdieie yingyvvkla dnlnldpncc kvnktigela 361 tmrlalnrsr singdwrkd // LOCUS NP_011931 538 aa linear PLN 30-JUN-2025 DEFINITION ribosome-associated complex protein SSZ1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011931 VERSION NP_011931.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179194.1 REFERENCE 1 (residues 1 to 538) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 538) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 538) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 538) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06757. On Oct 2, 2003 this sequence version replaced NP_011931.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..538 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..538 /product="ribosome-associated complex protein SSZ1" /calculated_mol_wt="58107" Region 4..386 /region_name="ASKHA_NBD_HSP70_ScSsz1p-like" /note="nucleotide-binding domain (NBD) of Saccharomyces cerevisiae ribosome-associated complex subunit Ssz1 and similar proteins; cd10232" /db_xref="CDD:466830" CDS 1..538 /gene="SSZ1" /locus_tag="YHR064C" /gene_synonym="PDR13" /coded_by="NM_001179194.1:1..1617" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10792726]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:11929994]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:15456889]" /experiment="EXISTENCE:mutant phenotype:GO:0006452 translational frameshifting [PMID:16607023]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:11054575]" /experiment="EXISTENCE:mutant phenotype:GO:0051083 'de novo' cotranslational protein folding [PMID:11274393]" /note="Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP" /db_xref="GeneID:856461" /db_xref="SGD:S000001106" ORIGIN 1 msspvigitf gntsssiayi npkndvdvia npdgeraips alsyvgedey hggqalqqli 61 rnpkntiinf rdfiglpfdk cdvskcanga pavevdgkvg fvisrgegke ekltvdevvs 121 rhlnrlklaa edyigsavke avltvptnfs eeqktalkas aakiglqivq finepsaall 181 ahaeqfpfek dvnvvvadfg girsdaavia vrngiftila tahdlslggd nldtelveyf 241 asefqkkyqa nprknarsla klkanssitk ktlsnatsat isidsladgf dyhasinrmr 301 yelvankvfa qfssfvdsvi akaeldpldi davlltggvs ftpklttnle ytlpesveil 361 gpqnknasnn pnelaasgaa lqarlisdyd adelaealqp vivntphlkk pigligakge 421 fhpvllaets fpvqkkltlk qakgdfligv yegdhhieek tlepipkeen aeeddesews 481 ddepevvrek lytlgtklme lgiknangve iifninkdga lrvtardlkt gnavkgel // LOCUS NP_011932 501 aa linear PLN 30-JUN-2025 DEFINITION RNA-dependent ATPase RRP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011932 VERSION NP_011932.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179195.1 REFERENCE 1 (residues 1 to 501) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 501) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 501) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 501) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06758. On Oct 2, 2003 this sequence version replaced NP_011932.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..501 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..501 /product="RNA-dependent ATPase RRP3" /EC_number="3.6.4.13" /calculated_mol_wt="55838" Region 82..489 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..501 /gene="RRP3" /locus_tag="YHR065C" /coded_by="NM_001179195.1:1..1506" /experiment="EXISTENCE:curator inference:GO:0005730 nucleolus [PMID:16449634]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23153376]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:18975973|PMID:23153376]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16449634]" /note="Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity" /db_xref="GeneID:856462" /db_xref="SGD:S000001107" ORIGIN 1 mskivkrkek kandeltsla ekirakalen qkklieaeke ggsesdseed ataekkkvlk 61 skskstvstq nentnedesf esfselnlvp eliqacknln yskptpiqsk aippaleghd 121 iiglaqtgsg ktaafaipil nrlwhdqepy yacilaptre laqqiketfd slgslmgvrs 181 tcivggmnmm dqardlmrkp hiiiatpgrl mdhlentkgf slrklkflvm deadrlldme 241 fgpvldrilk iiptqertty lfsatmtski dklqrasltn pvkcavsnky qtvdtlvqtl 301 mvvpgglknt yliyllnefi gktmiiftrt kanaerlsgl cnllefsata lhgdlnqnqr 361 mgsldlfkag krsilvatdv aargldipsv divvnydipv dsksyihrvg rtaragrsgk 421 sislvsqydl elilrieevl gkklpkesvd kniiltlrds vdkangevvm emnrrnkeki 481 argkgrrgrm mtrenmdmge r // LOCUS NP_011933 453 aa linear PLN 30-JUN-2025 DEFINITION rRNA-binding ribosome biosynthesis protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011933 VERSION NP_011933.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179196.1 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 453) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06759. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..453 /product="rRNA-binding ribosome biosynthesis protein" /calculated_mol_wt="51633" Region 26..220 /region_name="Brix" /note="The Brix domain is found in a number of eukaryotic proteins; smart00879" /db_xref="CDD:214879" CDS 1..453 /gene="SSF1" /locus_tag="YHR066W" /coded_by="NM_001179196.1:1..1362" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9611192]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:11864606]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11864607]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:11864606]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11864607]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /note="Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication" /db_xref="GeneID:856463" /db_xref="SGD:S000001108" ORIGIN 1 makrrqkkrt haqltpeqeq gipksmvirv gqtslanhsl nqlvkdfrqi mqphtaiklk 61 erksnklkdf vvmcgplgvt hlfmftqsek tgnvslkiar tpqgptvtfq vldyslgrdi 121 kkflkrpksl nnddvlnppl lvlngfstsk rsgeddqdvn vekvivsmfq nifpplnpar 181 tslnsikrvf minkdretge ismrhyfidi reveisrnlk rlykaknnls ktvpnlhrke 241 disslildhd lgaytsesei eddaivrvvd nqdvkakhsq slksqrtpve kkdnkereke 301 teeedvemee pkpsenlqpt prkkaiklte lgprltlklv kieegicsgk vlhhefvqks 361 seeikalekr haakmrlkeq rkkeqeenia kkkavkdakk qrklerrkar aaeggegqgk 421 ddamsddess ssdsehygsv pedldsdlfs eve // LOCUS NP_011934 280 aa linear PLN 30-JUN-2025 DEFINITION hydroxyacyl-thioester dehydratase HTD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011934 VERSION NP_011934.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179197.1 REFERENCE 1 (residues 1 to 280) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 280) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 280) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 280) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06760. Method: conceptual translation. FEATURES Location/Qualifiers source 1..280 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..280 /product="hydroxyacyl-thioester dehydratase HTD2" /calculated_mol_wt="32924" Region 4..249 /region_name="HTD2" /note="Hydroxyacyl-ACP dehydratase HTD2, hotdog domain [Lipid transport and metabolism]; COG3777" /db_xref="CDD:442991" Region 171..>249 /region_name="hot_dog" /note="The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; cl00509" /db_xref="CDD:469797" Site order(209..210,236..239) /site_type="active" /note="active site 2 [active]" /db_xref="CDD:239539" Site order(215,218..219,222,231..233) /site_type="active" /note="active site 1 [active]" /db_xref="CDD:239539" CDS 1..280 /gene="HTD2" /locus_tag="YHR067W" /gene_synonym="RMD12" /coded_by="NM_001179197.1:1..843" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:15387819|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [PMID:15387819]" /note="Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology" /db_xref="GeneID:856464" /db_xref="SGD:S000001109" ORIGIN 1 mksktwifrd vlsshrtkaf dsllcrrlpv skatkhlqlg ehflffppsf ekldrdgyfn 61 yqnpasllgn pdlryrrriw gqgelvqylp vtldqeytch esikyvkkir dehvvciert 121 llqerpenvs spmdiclfer rvlmytnspa nktavkmpvg eenykilknf tvtdmdivay 181 gqmslnphri hwdkeysryv egyddiimqg pfsvqllqkc iqpfleqpir qlryrnlnyi 241 ypnttlsicq slssssgmyt fqirdlqkan lvymkadvfc // LOCUS NP_011935 387 aa linear PLN 30-JUN-2025 DEFINITION deoxyhypusine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011935 VERSION NP_011935.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179198.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 387) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06761. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..387 /product="deoxyhypusine synthase" /EC_number="2.5.1.46" /calculated_mol_wt="42761" Region 47..375 /region_name="DS" /note="Deoxyhypusine synthase; pfam01916" /db_xref="CDD:460382" CDS 1..387 /gene="DYS1" /locus_tag="YHR068W" /coded_by="NM_001179198.1:1..1164" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008612 peptidyl-lysine modification to peptidyl-hypusine [PMID:7629166]" /experiment="EXISTENCE:direct assay:GO:0034038 deoxyhypusine synthase activity [PMID:7629166]" /note="Deoxyhypusine synthase; catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric; human homolog DHPS allows growth of yeast haploid dys1 null mutant after sporulation of heterozygous diploid" /db_xref="GeneID:856465" /db_xref="SGD:S000001110" ORIGIN 1 msdineklpe llqdavlkas vpipddfvkv qgidyskpea tnmratdlie amktmgfqas 61 svgtaceiid smrswrgkhi delddhekkg cfdeegyqkt tifmgytsnl issgvretlr 121 ylvqhkmvda vvtsaggvee dlikclapty lgefalkgks lrdqgmnrig nllvpndnyc 181 kfeewivpil dkmleeqdey vkkhgadcle anqdvdspiw tpskmidrfg keindessvl 241 ywahknkipi fcpsltdgsi gdmlffhtfk aspkqlrvdi vgdirkinsm smaayragmi 301 ilggglikhh ianaclmrng adyavyintg qeydgsdaga rpdeavswgk ikaeaksvkl 361 fadvttvlpl ivaatfasgk pikkvkn // LOCUS NP_011936 359 aa linear PLN 30-JUN-2025 DEFINITION exosome non-catalytic core subunit RRP4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011936 VERSION NP_011936.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179199.1 REFERENCE 1 (residues 1 to 359) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 359) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 359) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 359) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06762. Method: conceptual translation. FEATURES Location/Qualifiers source 1..359 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..359 /product="exosome non-catalytic core subunit RRP4" /calculated_mol_wt="39296" Region 54..91 /region_name="ECR1_N" /note="Exosome complex exonuclease RRP4 N-terminal region; pfam14382" /db_xref="CDD:464162" Region 103..194 /region_name="S1_Rrp4" /note="Rrp4 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in...; cd05789" /db_xref="CDD:240215" Site order(103,115,117,131) /site_type="other" /note="subunit interface [polypeptide binding]" /db_xref="CDD:240215" Site order(117,125,135,137) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240215" Region 197..345 /region_name="KH-I_Rrp4_eukar" /note="type I K homology (KH) RNA-binding domain found in exosome complex component Rrp4 from eukaryote; cd22525" /db_xref="CDD:411953" Site order(197,206,209,211..212,214,232,291,294,297..298, 301..302,310..311,332..333) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:411953" CDS 1..359 /gene="RRP4" /locus_tag="YHR069C" /coded_by="NM_001179199.1:1..1080" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:19046973|PMID:10465791]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:17643380|PMID:15828860]" /experiment="EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:11586364]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10465791|PMID:9390555|PMID:10508172|PMID:8600032]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:9482746]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10611222]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:10465791]" /experiment="EXISTENCE:mutant phenotype:GO:0071051 poly(A)-dependent snoRNA 3'-end processing [PMID:10611222]" /note="Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; mutations in the human ortholog, EXOSC2, cause SHRF (Short stature, Hearing loss, Retinitis pigmentosa and distinctive Facies) syndrome, an RNA exosomopathy" /db_xref="GeneID:856466" /db_xref="SGD:S000001111" ORIGIN 1 msevititkr ngafqnssnl synntgisdd endeediymh dvnsaskses dsqivtpgel 61 vtddpiwmrg hgtyfldnmt yssvagtvsr vnrllsvipl kgryapetgd hvvgriaevg 121 nkrwkvdigg kqhavlmlgs vnlpggilrr ksesdelqmr sflkegdlln aevqslfqdg 181 saslhtrslk ygklrngmfc qvpsslivra knhthnlpgn itvvlgvngy iwlrktsqmd 241 lardtpsann sssikstgpt gavslnpsit rleeesswqi ysdendpsis nnirqaicry 301 anvikalafc eigitqqriv sayeasmvys nvgelieknv mesigsdilt aekmrgngn // LOCUS NP_011937 499 aa linear PLN 30-JUN-2025 DEFINITION tRNA (guanine) methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011937 VERSION NP_011937.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179200.1 REFERENCE 1 (residues 1 to 499) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 499) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 499) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 499) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06763. Method: conceptual translation. FEATURES Location/Qualifiers source 1..499 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..499 /product="tRNA (guanine) methyltransferase" /EC_number="2.1.1.228" /calculated_mol_wt="56383" Region 176..436 /region_name="Met_10" /note="Met-10+ like-protein; pfam02475" /db_xref="CDD:396850" CDS 1..499 /gene="TRM5" /locus_tag="YHR070W" /coded_by="NM_001179200.1:1..1500" /experiment="EXISTENCE:direct assay:GO:0002939 tRNA N1-guanine methylation [PMID:17652090]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17652090|PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:17652090]" /experiment="EXISTENCE:direct assay:GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity [PMID:17652090]" /experiment="EXISTENCE:direct assay:GO:0070901 mitochondrial tRNA methylation [PMID:17652090]" /experiment="EXISTENCE:mutant phenotype:GO:0002939 tRNA N1-guanine methylation [PMID:11226173]" /experiment="EXISTENCE:mutant phenotype:GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity [PMID:11226173]" /note="tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cytoplasmic and mitochondrial tRNAs; mutations in human ortholog TRMT5 are associated with skeletal muscle respiratory chain deficiencies, and trm5 mutations analogous to disease mutations decrease respiration" /db_xref="GeneID:856467" /db_xref="SGD:S000001112" ORIGIN 1 mkialpvfqk fnrlissckm sgvfpynppv nrqmreldrs ffitkipmca vkfpepknis 61 vfsknfknci lrvpriphvv klnsskpkde ltsvqnkklk tadgnntpvt kgvllhesih 121 svedaygklp edalaflken saeivpheyv ldydfwkaee ilravlpeqf leevptgfti 181 tghiahlnlr tefkpfdsli gqvildknnk iecvvdkvss iatqfrtfpm kviagksdsl 241 vveqkesnct fkfdfskvyw nsrlhteher lvkqyfqpgq vvcdvfagvg pfavpagkkd 301 vivlandlnp esykylkeni alnkvaktvk sfnmdgadfi rqspqllqqw iqdeeggkit 361 iplplkkrhr sqqhndqqpp qprtkeliip shishyvmnl pdsaisflgn frgifaahtk 421 gatdtiqmpw vhvhcfekyp pgdqvtedel harvhariia alkvtaddlp lnavslhlvr 481 kvaptkpmyc asfqlpanv // LOCUS NP_011938 229 aa linear PLN 30-JUN-2025 DEFINITION Pcl5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011938 VERSION NP_011938.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179201.1 REFERENCE 1 (residues 1 to 229) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 229) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 229) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 229) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06764. Method: conceptual translation. FEATURES Location/Qualifiers source 1..229 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..229 /product="Pcl5p" /calculated_mol_wt="26336" Region 82..176 /region_name="CYCLIN_ScPCL1-like" /note="cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; cd20557" /db_xref="CDD:410260" Site order(96,140,148..150,164,167..168) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410260" CDS 1..229 /gene="PCL5" /locus_tag="YHR071W" /coded_by="NM_001179201.1:1..690" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19218424]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:12101234]" /experiment="EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:20417603]" /experiment="EXISTENCE:mutant phenotype:GO:0031647 regulation of protein stability [PMID:12101234]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:16611745]" /note="Cyclin; interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity" /db_xref="GeneID:856468" /db_xref="SGD:S000001113" ORIGIN 1 mdgnhrftpd skefntvvks kesstgrnpy qtpplehngt hhqtnysrkk tnlaiiisnf 61 lseisrplsn gkinnsthni lkflnevlkr skcskenavl atfyfqkihq srgvrdessl 121 pefshcsrri flcclilshk flndntysmk nwqiisglha kdlslmerwc lgklnyelai 181 pydefllwet ntlmkaklrv gtpanapvkr presdndyda nswkqiksc // LOCUS NP_011939 731 aa linear PLN 30-JUN-2025 DEFINITION lanosterol synthase ERG7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011939 VERSION NP_011939.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179202.2 REFERENCE 1 (residues 1 to 731) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 731) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 731) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 731) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06765. On Apr 26, 2011 this sequence version replaced NP_011939.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..731 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..731 /product="lanosterol synthase ERG7" /EC_number="5.4.99.7" /calculated_mol_wt="83330" Region 77..722 /region_name="SQCY_1" /note="Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; cd02892" /db_xref="CDD:239222" Site order(99,104..105,108,158,192,194,198,234..235,238, 340..341,345,384..385,390,445,454,456..457,510,525..526, 528,532,543,587,593,700,703,705,707,710) /site_type="active" /note="Active site cavity [active]" /db_xref="CDD:239222" Site 456 /site_type="active" /note="catalytic acid [active]" /db_xref="CDD:239222" CDS 1..731 /gene="ERG7" /locus_tag="YHR072W" /coded_by="NM_001179202.2:1..2196" /experiment="EXISTENCE:direct assay:GO:0000250 lanosterol synthase activity [PMID:12842197]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093|PMID:10515935|PMID:11706015]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:12842197]" /experiment="EXISTENCE:mutant phenotype:GO:0000250 lanosterol synthase activity [PMID:18842050]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:200835]" /note="Lanosterol synthase; an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis; human LSS functionally complements the lethality of the erg7 null mutation" /db_xref="GeneID:856470" /db_xref="SGD:S000001114" ORIGIN 1 mtefysdtig lpktdprlwr lrtdelgres weyltpqqaa ndppstftqw llqdpkfpqp 61 hpernkhspd fsafdachng asffkllqep dsgifpcqyk gpmfmtigyv avnyiagiei 121 peherielir yivntahpvd ggwglhsvdk stvfgtvlny vilrllglpk dhpvcakars 181 tllrlggaig sphwgkiwls alnlykwegv npappetwll pyslpmhpgr wwvhtrgvyi 241 pvsylslvkf scpmtpllee lrneiytkpf dkinfsknrn tvcgvdlyyp hsttlnians 301 lvvfyekylr nrfiyslskk kvydliktel qntdslciap vnqafcalvt lieegvdsea 361 fqrlqyrfkd alfhgpqgmt imgtngvqtw dcafaiqyff vaglaerpef yntivsaykf 421 lchaqfdtec vpgsyrdkrk gawgfstktq gytvadctae aikaiimvkn spvfsevhhm 481 isserlfegi dvllnlqnig sfeygsfaty ekikaplame tlnpaevfgn imveypyvec 541 tdssvlglty fhkyfdyrke eirtririai efikksqlpd gswygswgic ftyagmfale 601 alhtvgetye nsstvrkgcd flvskqmkdg gwgesmksse lhsyvdseks lvvqtawali 661 allfaeypnk evidrgidll knrqeesgew kfesvegvfn hscaieypsy rflfpikalg 721 mysrayetht l // LOCUS NP_058135 58 aa linear PLN 30-JUN-2025 DEFINITION snoRNP complex protein NOP10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_058135 VERSION NP_058135.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184438.1 REFERENCE 1 (residues 1 to 58) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 58) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 58) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 58) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06766. Method: conceptual translation. FEATURES Location/Qualifiers source 1..58 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..58 /product="snoRNP complex protein NOP10" /calculated_mol_wt="6505" Region 4..52 /region_name="Nop10p" /note="Nucleolar RNA-binding protein, Nop10p family; pfam04135" /db_xref="CDD:427735" CDS 1..58 /gene="NOP10" /locus_tag="YHR072W-A" /coded_by="NM_001184438.1:1..177" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9843512]" /experiment="EXISTENCE:direct assay:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9843512]" /experiment="EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:9843512]" /experiment="EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:9843512]" /note="Subunit of box H/ACA snoRNP complex; required for pseudouridylation and processing of pre-18S rRNA" /db_xref="GeneID:856471" /db_xref="SGD:S000007455" ORIGIN 1 mhlmytlgpd gkriytlkkv tesgeitksa hparfspddk ysrqrvtlkk rfglvpgq // LOCUS NP_011940 996 aa linear PLN 30-JUN-2025 DEFINITION oxysterol-binding protein related protein OSH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011940 VERSION NP_011940.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179203.1 REFERENCE 1 (residues 1 to 996) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 996) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 996) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 996) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 996) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 996) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 996) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06767. Method: conceptual translation. FEATURES Location/Qualifiers source 1..996 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..996 /product="oxysterol-binding protein related protein OSH3" /calculated_mol_wt="113629" Region 223..313 /region_name="PH_Osh3p_yeast" /note="Yeast oxysterol binding protein homolog 3 Pleckstrin homology (PH) domain; cd13289" /db_xref="CDD:241443" Region 642..985 /region_name="Oxysterol_BP" /note="Oxysterol-binding protein; pfam01237" /db_xref="CDD:460126" CDS 1..996 /gene="OSH3" /locus_tag="YHR073W" /coded_by="NM_001179203.1:1..2991" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11408574]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25420878]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:20008566]" /experiment="EXISTENCE:genetic interaction:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:12054531]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:12054531]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:17082746|PMID:12054531]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:16585271]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:24213531]" /note="Member of an oxysterol-binding protein family; this family has seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; contains FFAT motif; interacts with ER anchor Scs2p at patches at the plasma membrane; regulated by sterol binding" /db_xref="GeneID:856472" /db_xref="SGD:S000001115" ORIGIN 1 metidiqnrs fvvrwvkcgr gdvinyqikp lkksievgiy kklkssvddh asavhiapdt 61 ktlldyttks llhkgsssni eehhrrssqh shsssngsdn krkersyssl sisgiqqqsq 121 eiplreklsa sgftlvkrvg nvsgntmvqg dlevkdtdyy yafildnsss knakkkilfn 181 asvingdnqs mistrstppa rptalsrtst qqdmlfrvgq grylqgyllk krrkrlqgfk 241 krfftldfry gtlsyylndh nqtcrgeivi slssvsankk dkiiiidsgm evwvlkattk 301 enwqswvdal qtcfddqfed kdtstleenp dildddkevi nksspqdhdh ltptattksa 361 lshrqhtqkd mddiyvplps esyatfsmnl rliqqrleqc kkdslsykpt tlhqrsegln 421 gthssssvft nnrvssfnhs ssgmtssdsl aseevpsnkt yiehalynql adlevfvsrf 481 vtqgevlfkd hqilckkakd trvsltsyls endeffdaee eisrgviilp dteddinniv 541 eetpllgksd qneftkevql sgseqiasss vesyttnden hsrkhlknrh knrrrghphh 601 qktksaqsst etftskdlfa lsypksvtrr ndipeaaasp psllsflrkn vgkdlssiam 661 pvtsnepisi lqlisetfey aplltkatqr pdpitfvsaf aisflsiyrd ktrtlrkpfn 721 pllaetfeli redmgfrlis ekvshrppvf affaehldwe csytvtpsqk fwgksielnn 781 egilrlkfkt tgelfewtqp ttilknliag erymepvnef evhsskgdks hilfdkagmf 841 sgrsegfkvs iipppssnrk ketlagkwtq slanetthet iwevgdlvsn pkkkygftkf 901 tanlneitei ekgnlpptds rlrpdiraye egnvdkaeew klkleqlqre rrnkgqdvep 961 kyfekvskne wkyitgpksy werrkkhdws disqlw // LOCUS NP_011941 714 aa linear PLN 30-JUN-2025 DEFINITION glutamine-dependent NAD(+) synthetase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011941 VERSION NP_011941.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179204.1 REFERENCE 1 (residues 1 to 714) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 714) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 714) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 714) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06768. Method: conceptual translation. FEATURES Location/Qualifiers source 1..714 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..714 /product="glutamine-dependent NAD(+) synthetase" /EC_number="6.3.5.1" /calculated_mol_wt="80555" Region 4..704 /region_name="PLN02339" /note="NAD+ synthase (glutamine-hydrolysing)" /db_xref="CDD:177973" CDS 1..714 /gene="QNS1" /locus_tag="YHR074W" /coded_by="NM_001179204.1:1..2145" /experiment="EXISTENCE:direct assay:GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity [PMID:12771147|PMID:12898714]" /experiment="EXISTENCE:direct assay:GO:0004359 glutaminase activity [PMID:12771147]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12898714]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12898714]" /experiment="EXISTENCE:direct assay:GO:0009435 NAD+ biosynthetic process [PMID:12771147|PMID:12898714]" /experiment="EXISTENCE:mutant phenotype:GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity [PMID:12771147|PMID:12898714]" /experiment="EXISTENCE:mutant phenotype:GO:0004359 glutaminase activity [PMID:12771147]" /experiment="EXISTENCE:mutant phenotype:GO:0009435 NAD+ biosynthetic process [PMID:12898714|PMID:12771147]" /note="Glutamine-dependent NAD(+) synthetase; essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide" /db_xref="GeneID:856473" /db_xref="SGD:S000001116" ORIGIN 1 mshlitlatc nlnqwaldfe gnrdrilqsi kiakergarl rvgpeleitg ygcldhflen 61 dvclhswemy aqiiknketh glildigmpv lhknvryncr llsldgeilf irpkiwland 121 gnyremrfft pwmkpgvved filppeiqkv tgqrlvpfgd avinsldtci gtetceelft 181 pqsphiamsl dgveimtnss gshhelrkln krldlilnat krcggvylya nqrgcdgdrl 241 yydgcaliai ngtivaqgsq fslddvevvt atvdleevrs yraavmsrgl qaslaeikfk 301 ridipvelal mtsrfdptvc ptkvrepfyh speeeialgp acwmwdylrr cngtgfflpl 361 sggidscata mivhsmcrlv tdaaqngneq vikdvrkitr sgddwipdsp qdlaskifhs 421 cfmgtenssk etrnrakdls naigsyhvdl kmdslvssvv slfevatgkk piykifggsq 481 ienlalqniq arlrmvlsyl faqllpwvrg ipnsggllvl gsanvdeclr gyltkydcss 541 adinpiggis ktdlkrfiay askqynmpil ndflnatpta elepmtkdyv qsdeidmgmt 601 yeelgvfgyl rkvekcgpys mflkllhqws pkltprqise kvkrffffya inrhkqtvlt 661 psyhaeqysp ednrfdlrpf linprfpwas rkidevveqc eahkgstldi msid // LOCUS NP_011942 400 aa linear PLN 30-JUN-2025 DEFINITION phosphoprotein phosphatase methylesterase 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011942 VERSION NP_011942.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179205.1 REFERENCE 1 (residues 1 to 400) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 400) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 400) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 400) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06769. Method: conceptual translation. FEATURES Location/Qualifiers source 1..400 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..400 /product="phosphoprotein phosphatase methylesterase 1" /EC_number="3.1.1.89" /calculated_mol_wt="44757" Region 114..366 /region_name="Abhydrolase_1" /note="alpha/beta hydrolase fold; pfam00561" /db_xref="CDD:395444" CDS 1..400 /gene="PPE1" /locus_tag="YHR075C" /coded_by="NM_001179205.1:1..1203" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:9151978]" /experiment="EXISTENCE:mutant phenotype:GO:0051723 protein methylesterase activity [PMID:11060018]" /experiment="EXISTENCE:mutant phenotype:GO:1990577 C-terminal protein demethylation [PMID:11060018]" /note="Protein with carboxyl methyl esterase activity; may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein" /db_xref="GeneID:856474" /db_xref="SGD:S000001117" ORIGIN 1 msddlrrkia lsqferaknv ldatfqeaye ddendgdalg slpsfngqsn rnrkytgktg 61 sttdrisske ksslptwsdf fdnkelvslp drdldvntyy tlptsllsnt tsipififhh 121 gagssglsfa nlakelntkl egrcgcfafd arghaetkfk kadapicfdr dsfikdfvsl 181 lnywfkskis qeplqkvsvi lighslggsi ctfaypklst elqkkilgit mldiveeaai 241 malnkvehfl qntpnvfesi ndavdwhvqh alsrlrssae iaipalfapl ksgkvvritn 301 lktfspfwdt wftdlshsfv glpvskllil agnenldkel ivgqmqgkyq lvvfqdsghf 361 iqedspikta itlidfwkrn dsrnvviktn wgqhktvqnt // LOCUS NP_011943 343 aa linear PLN 30-JUN-2025 DEFINITION type 2C protein phosphatase PTC7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011943 VERSION NP_011943.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179206.1 REFERENCE 1 (residues 1 to 343) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 343) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 343) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 343) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06770. On Jul 30, 2007 this sequence version replaced NP_011943.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..343 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..343 /product="type 2C protein phosphatase PTC7" /EC_number="3.1.3.16" /calculated_mol_wt="37651" Region 71..302 /region_name="PP2C_SIG" /note="Sigma factor PP2C-like phosphatases; smart00331" /db_xref="CDD:214624" Site order(90..91,109..111,265,333) /site_type="active" /db_xref="CDD:238083" CDS 1..343 /gene="PTC7" /locus_tag="YHR076W" /coded_by="NM_001179206.1:1..1032" /experiment="EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:23940037]" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:23940037|PMID:12220683]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:19564484]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:23940037|PMID:16823961|PMID:14576278|PMID:11327310|P MID:19564484|PMID:18180296|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006470 protein dephosphorylation [PMID:23940037]" /note="Type 2C serine/threonine protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope; activates coenzyme Q6 biosynthesis by dephosphorylation of demethoxy-Q6 hydroxylase Coq7p" /db_xref="GeneID:856475" /db_xref="SGD:S000001118" ORIGIN 1 mfanvgfrtl rvsrgplygs csqiisfskr tfyssaksgy qsnnshgday ssgsqsgpft 61 yktavafqpk drddliyqkl kdsirsptge dnyfvtsnnv hdifagvadg vggwaehgyd 121 ssaisrelck kmdeistala enssketllt pkkiigaaya kirdekvvkv ggttaivahf 181 psngklevan lgdswcgvfr dsklvfqtkf qtvgfnapyq lsiipeemlk eaerrgskyi 241 lntprdadey sfqlkkkdii ilatdgvtdn iatddielfl kdnaartnde lqllsqkfvd 301 nvvslskdpn ypsvfaqeis kltgknysgg kedditvvvv rvd // LOCUS NP_011944 1089 aa linear PLN 30-JUN-2025 DEFINITION Nmd2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011944 VERSION NP_011944.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179207.1 REFERENCE 1 (residues 1 to 1089) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1089) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1089) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1089) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1089) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1089) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1089) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06771. On Dec 15, 1999 this sequence version replaced NP_011944.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1089 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1089 /product="Nmd2p" /calculated_mol_wt="126617" Region 34..241 /region_name="MIF4G" /note="MIF4G domain; pfam02854" /db_xref="CDD:397130" Region 374..561 /region_name="MIF4G" /note="Middle domain of eukaryotic initiation factor 4G (eIF4G); smart00543" /db_xref="CDD:214713" Region 578..779 /region_name="MIF4G" /note="MIF4G domain; pfam02854" /db_xref="CDD:397130" Region 976..1084 /region_name="Upf2" /note="Up-frameshift suppressor 2; pfam04050" /db_xref="CDD:461146" CDS 1..1089 /gene="NMD2" /locus_tag="YHR077C" /gene_synonym="IFS1; SUA1; SUP111; UPF2" /coded_by="NM_001179207.1:1..3270" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16043493]" /experiment="EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:16611983]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:23390378]" /note="Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; acts as a scaffold protein bridging Nam7p and Upf3p; involved in telomere maintenance; contains an acidic domain and three middle domains of eukaryotic initiation factor 4G (mIF4G) with aspartic 59 of mIF4G-1 important for NMD activity and translation termination accuracy" /db_xref="GeneID:856476" /db_xref="SGD:S000001119" ORIGIN 1 mddgrkkelh dlntrawnge evfplkskkl dssikrntgf ikklkkgfvk gsessllkdl 61 seaslekyls eiivtvtecl lnvlnknddv iaaveiisgl hqrfngrfts pllgaflqaf 121 enpsvdiese rdelqritrv kgnlrvftel ylvgvfrtld dieskdaipn flqkktgrkd 181 pllfsilrei lnykfklgft ttiatafikk faplfrdddn swddliydsk lkgalqslfk 241 nfidatfara telhkkvnkl qrehqkcqir tgklrdeyve eydkllpifi rfktsaitlg 301 effkleipel egasnddlke taspmitnqi lppnqrlwen edtrkfyeil pdisktvees 361 qssktekdsn vnskninlff tdlemadckd iiddlsnryw ssyldnkatr nrilkffmet 421 qdwsklpvys rfiatnskym peivsefiny ldngfrsqlh snkinvknii ffsemikfql 481 ipsfmifhki rtlimymqvp nnveiltvll ehsgkfllnk peykelmekm vqlikdkknd 541 rqlnmnmksa leniitllyp psvkslnvtv ktitpeqqfy rilirselss ldfkhivklv 601 rkahwddvai qkvlfslfsk phkisyqnip lltkvlggly syrrdfvirc idqvlenier 661 gleindygqn mhrisnvryl teifnfemik sdvlldtiyh iirfghinnq pnpfylnysd 721 ppdnyfriql vttillninr tpaaftkkck lllrffeyyt fikeqplpke tefrvsstfk 781 kyenifgntk fersenlves asrlesllks lnaikskddr vkgssasihn gkesavpies 841 iteddededd enddgvdllg ededaeistp ntesapgkhq akqdeseded dedddedddd 901 ddddddddge egdedddedd ddeddddeee edsdsdleyg gdldadrdie mkrmyeeyer 961 klkdeeerka eeelerqfqk mmqesidark sekvvaskip viskpvsvqk plllkkseep 1021 sssketyeel skpkkiaftf ltksgkktqs rilqlptdvk fvsdvleeee klkternkik 1081 kivlkrsfd // LOCUS NP_011945 552 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR078W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011945 VERSION NP_011945.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179208.1 REFERENCE 1 (residues 1 to 552) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 552) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 552) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 552) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06772. Method: conceptual translation. FEATURES Location/Qualifiers source 1..552 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..552 /product="uncharacterized protein" /calculated_mol_wt="63200" Region 183..262 /region_name="GPHR_N" /note="The Golgi pH Regulator (GPHR) Family N-terminal; pfam12537" /db_xref="CDD:463623" Region 309..542 /region_name="ABA_GPCR" /note="Abscisic acid G-protein coupled receptor; pfam12430" /db_xref="CDD:463577" CDS 1..552 /locus_tag="YHR078W" /coded_by="NM_001179208.1:1..1659" /note="High osmolarity-regulated gene of unknown function" /db_xref="GeneID:856477" /db_xref="SGD:S000001120" ORIGIN 1 mealivfivl svsgafaykc syerlwfkvg slfdiistss kknviplask mevgsnedvs 61 smgnfinkfy teyslpshkv lqslrvlfsl ammtytvtie iilwqikvag mdkevtfitt 121 wvwpltaiml sfililfqpf fiiisllnkf yndkfdidrl iivtciilst liallsyini 181 gpfqytknil trlsiggvtv maslsglatv sslyynflvi whkfrntpms dpsfrninns 241 nnnsksllwt tdayieekiq dyehnieqnv qilrsleeev genstfkael mekiawyqle 301 lgkleallqq spqvrtfkka fevgfiiycl hkliitflkr ipyiiyhslk ypddydyenf 361 senaasdpla itianildfs ffrfnyqhdl dsltkqislf lsislflccl savnttisyv 421 vtllpikfqi lalfamqndd tanvlpeytn nssykgkkrn ysqeqkgisl iknlvvselt 481 gvyvlattlm vrshlpfevs qrlkellggk ftvpnivids wfdevyafac vftficiria 541 erklstkkvs ve // LOCUS NP_011946 1115 aa linear PLN 30-JUN-2025 DEFINITION bifunctional endoribonuclease/protein kinase IRE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011946 VERSION NP_011946.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179209.1 REFERENCE 1 (residues 1 to 1115) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1115) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1115) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1115) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06773. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1115 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1115 /product="bifunctional endoribonuclease/protein kinase IRE1" /EC_number="2.7.11.1" /calculated_mol_wt="126845" Region 120..407 /region_name="Luminal_IRE1" /note="The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1; cd09769" /db_xref="CDD:188875" Site order(201..205,224,226..229,231..233,245,247..249,252, 281..282,290,292,305,307..309) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:188875" Region 672..981 /region_name="STKc_IRE1" /note="Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; cd13982" /db_xref="CDD:270884" Site order(672,694..695,697,720..721,723,725,730..734,746,783, 786..787,790..791,823,972,975) /site_type="other" /note="dimer interface (back-to-back) [polypeptide binding]" /db_xref="CDD:270884" Site order(678,691,840..841,899,945..947,970) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:270884" Site order(680..684,689,700,702,729,745..748,751,753,797,799, 801..802,804,828,831,851..854) /site_type="active" /db_xref="CDD:270884" Site order(680..684,687,689,700,702,729,745..746,748,751, 801..802,804,828) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270884" Site order(682,685..686,688,703,705,737,739..740,925..926, 928..929,932) /site_type="other" /note="dimer interface (face-to-face) [polypeptide binding]" /db_xref="CDD:270884" Site order(684,751,753,797,799,801,831,851..854) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270884" Site order(827..842,847..854) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270884" Region 984..1113 /region_name="RNase_Ire1" /note="RNase domain (also known as the kinase extension nuclease domain) of Ire1; cd10422" /db_xref="CDD:199217" Site order(984..985,988,992,1059,1077,1108,1111..1112) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:199217" Site order(986,1085,1089,1092..1093,1097) /site_type="other" /note="kinase interface [polypeptide binding]" /db_xref="CDD:199217" Site order(988,992,995..996,1056,1059..1060,1063,1076..1078, 1107..1108,1111) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:199217" CDS 1..1115 /gene="IRE1" /locus_tag="YHR079C" /gene_synonym="ERN1" /coded_by="NM_001179209.1:1..3348" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:9323131]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8663458]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17035634]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8358794]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:17923530]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:18971375]" /experiment="EXISTENCE:mutant phenotype:GO:0006020 inositol metabolic process [PMID:1625574]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:8513503|PMID:8358794]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:8898193|PMID:18971375]" /experiment="EXISTENCE:mutant phenotype:GO:0034067 protein localization to Golgi apparatus [PMID:26966233]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:26966233]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:17923530]" /note="Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; role in homeostatic adaptation to ER stress; Kar2p binds inactive Ire1p and releases from it upon ER stress" /db_xref="GeneID:856478" /db_xref="SGD:S000001121" ORIGIN 1 mrllrrnmlv ltllvcvfss iiscsiplss rtsrrqived evastkklnf nygvdknins 61 pipaprtteg lpnmklssyp tpnllntadn rrankkgrra ansisvpyle nrslnelsls 121 diliaadveg glhavdrrng hiiwsiepen fqplieiqep srletyetli iepfgdgniy 181 yfnahqglqk lplsirqlvs tsplhlktni vvndsgkive dekvytgsmr timytinmln 241 geiisafgpg skngyfgsqs vdcspeekik lqecenmivi gktifelgih sydgasynvt 301 ystwqqnvld vplalqntfs kdgmciapfr dksllasdld friarwvspt fpgiivglfd 361 vfndlrtnen ilvphpfnpg dhesissnkv yldqtsnlsw falssqnfps lvesapisry 421 assdrwrvss ifedetlfkn aimgvhqiyn neydhlyeny ektnsldtth kypplmidss 481 vdttdlhqnn emnslkeyms pedleayrkk iheqisreld eknqnslllk fgslvyriie 541 tgvflllfli fcailqrfki lpplyvllsk igfmpekeip iveskslncp sssenvtkpf 601 dmksgkqvvf egavndgslk sekdnddade ddeksldltt ekkkrkrgsr ggkkgrksri 661 anipnfeqsl knlvvsekil gygssgtvvf qgsfqgrpva vkrmlidfcd ialmeikllt 721 esddhpnvir yycsettdrf lyialelcnl nlqdlveskn vsdenlklqk eynpisllrq 781 iasgvahlhs lkiihrdlkp qnilvstssr ftadqqtgae nlrilisdfg lckkldsgqs 841 sfrtnlnnps gtsgwrapel leesnnlqcq vetehsssrh tvvssdsfyd pftkrrltrs 901 idifsmgcvf yyilskgkhp fgdkysresn iirgifslde mkclhdrsli aeatdlisqm 961 idhdplkrpt amkvlrhplf wpkskklefl lkvsdrleie nrdppsallm kfdagsdfvi 1021 psgdwtvkfd ktfmdnlery rkyhssklmd llralrnkyh hfmdlpedia elmgpvpdgf 1081 ydyftkrfpn lligvymivk enlsddqilr eflys // LOCUS NP_011947 91 aa linear PLN 30-JUN-2025 DEFINITION Sae3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011947 VERSION NP_011947.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180026.1 REFERENCE 1 (residues 1 to 91) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 91) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 91) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 91) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 91) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 91) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 91) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06774. On Nov 10, 2005 this sequence version replaced NP_011947.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..91 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..91 /product="Sae3p" /calculated_mol_wt="10696" Region 11..90 /region_name="Swi5" /note="pfam07061" /db_xref="CDD:462077" CDS 1..91 /gene="SAE3" /locus_tag="YHR079C-A" /gene_synonym="YHR079C-B" /coded_by="NM_001180026.1:1..276" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:15579681|PMID:15620352]" /experiment="EXISTENCE:mutant phenotype:GO:0000707 meiotic DNA recombinase assembly [PMID:15579681|PMID:15620352]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:9215889]" /note="Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p" /db_xref="GeneID:856479" /db_xref="SGD:S000001957" ORIGIN 1 mnyletqlnk kqkqiqeyes mngnlikmfe qlskekknde tpkkisstyi kelkeynelr 61 daglrlaqii adekqckikd vfeeigysmk d // LOCUS NP_011948 1345 aa linear PLN 30-JUN-2025 DEFINITION Lam4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011948 VERSION NP_011948.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179210.1 REFERENCE 1 (residues 1 to 1345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1345) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06775. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1345 /product="Lam4p" /calculated_mol_wt="149549" Region 561..654 /region_name="PH-GRAM_GRAMDC" /note="GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; cd13220" /db_xref="CDD:275406" Region 761..910 /region_name="VASt" /note="VAD1 Analog of StAR-related lipid transfer domain; pfam16016" /db_xref="CDD:464975" Region 974..1119 /region_name="VASt" /note="VAD1 Analog of StAR-related lipid transfer domain; pfam16016" /db_xref="CDD:464975" CDS 1..1345 /gene="LAM4" /locus_tag="YHR080C" /gene_synonym="LTC3" /coded_by="NM_001179210.1:1..4038" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:26001273]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:26001273]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:29339490]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:33255682]" /note="Sterol-binding protein that localizes to puncta in the cortical ER; sterol binding occurs via two StART-like domains; one of six StART-like domain-containing proteins in yeast that may be involved in intracellular sterol transfer between membranes; conserved across eukaryotes; has both GRAM and StART-like (VASt) domains; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:856480" /db_xref="SGD:S000001122" ORIGIN 1 mtrdskkkhh wgtaflrtig vkrkhkkdrn flnnttgenv sttasaerfr rvggnpdips 61 llkpetftes pakgsqkaaa sslahsqgvf nipividpme tnrlektntn ltagslkgrf 121 qdgnsnsnsv pslsvqalek eklqsgkreg ssnqaeektp dghdehtafe tflsfahnav 181 shipkinvqd adngtisrne pkdrkknssn isgalsenst nnkntsstke sdgpflknld 241 nilaasksst psnqqlntte agskskpssl srlafgnlkg hihsnshsss naisgddtsl 301 ddtrkmtddm arkvvfepir hshdkptpgv gnlklehfdd sqatleglea msaeslpead 361 hldsrgpvqq snlerktvps kwsvvssstt dgvkprrrak smisamadkq ntssdvlqdc 421 kkrlsfnssn gltnndpeye drepremskk flnrrsfspg sismgmkvlp stalkyslnk 481 vknstdiast iiprpsmsng rpssglrrss sksfsstpvn iiepseengr qssirikgve 541 yasekkdaef haifkdsgvs pnerlildhs calsrdillq grmyisdqhi gfysnilgwv 601 stvfipfkti vqiekratag ifpngividt lhtkytfasf tsrdatydli tevwnqiilg 661 krfrsnsnnt nsssnsisdd enddydddyd dygdddddly dnsnnisdst dmtssvsigk 721 pedlpmplqt dtpygtgipp lgpkihspte tvykpapnek lvnestihas lgrvvnilfg 781 kdvsyimail kaqknsdisp ipvlvdsptv segkkrdysy vkttpgaigp gktkcmitet 841 iqhfnleeyv qvlqttktpd vpsgnsfyvr tvyllswann netklklyvs vewtgkslik 901 spiekgtfdg vtdatkilve elgniltrsa tkrkrssken tvtvstlpkm epsshaptep 961 diqkdkddsi irenenipap lgtvvqllfg snteymqkvi trdknnvnve tipkftpslv 1021 eggsrhyeyt kklnnsigpk qtkclltesi ehmdinnyvl vtqttktpdv psgsnfaves 1081 kiflfwgqhd ttnmtvitki nwtsksflkg aiekgsvegq kvsvdymlse lrdiisraks 1141 kkpvkkvmks hdkhrpfhsk veqkssesrk sddnkdilth ildfvqnnfs seifmnklls 1201 pqklflilgl timlfwsprl hvfqeknnlq iikpgrllid gqeynyvpsf gtlynsyena 1261 isskkkrenv nyardkspiv gresdiwdwi snrgsaispr gramlrndde hklqqlsesi 1321 kitemqlnhm ktmldnierd andls // LOCUS NP_011949 184 aa linear PLN 30-JUN-2025 DEFINITION Lrp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011949 VERSION NP_011949.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179211.1 REFERENCE 1 (residues 1 to 184) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 184) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 184) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 184) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06776. Method: conceptual translation. FEATURES Location/Qualifiers source 1..184 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..184 /product="Lrp1p" /calculated_mol_wt="20914" Region 13..89 /region_name="Sas10_Utp3" /note="Sas10/Utp3/C1D family; pfam04000" /db_xref="CDD:461123" CDS 1..184 /gene="LRP1" /locus_tag="YHR081W" /gene_synonym="RRP47" /coded_by="NM_001179211.1:1..555" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:17704127]" /experiment="EXISTENCE:direct assay:GO:0003725 double-stranded RNA binding [PMID:17704127]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23580640]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:24937447]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:12837249|PMID:19046973]" /experiment="EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:17410208]" /experiment="EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:18591258]" /experiment="EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12972615]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:18614049]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:12972615]" /experiment="EXISTENCE:mutant phenotype:GO:0034476 U5 snRNA 3'-end processing [PMID:12972615]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:16652390]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:12972615]" /experiment="EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258|PMID:16973436]" /experiment="EXISTENCE:mutant phenotype:GO:0071051 poly(A)-dependent snoRNA 3'-end processing [PMID:12972615]" /note="Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; forms a stable heterodimer with Rrp6p and regulates its exonucleolytic activity; rapidly degraded by the proteasome in the absence of Rrp6p; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination" /db_xref="GeneID:856481" /db_xref="SGD:S000001123" ORIGIN 1 mediekikpy vrsfskalde lkpeieklts ksldeqllll sderakleli nryayvlssl 61 mfanmkvlgv kdmspilgel krvksymdka kqydnritks neksqaeqek akniisnvld 121 gnknqfepsi srsnfqgkht kfendelaes tttkiidstd hirkasskks krldkvgkkk 181 ggkk // LOCUS NP_011950 1029 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase KSP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011950 VERSION NP_011950.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179212.1 REFERENCE 1 (residues 1 to 1029) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1029) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1029) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1029) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1029) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1029) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1029) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06777. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1029 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1029 /product="putative serine/threonine protein kinase KSP1" /EC_number="2.7.11.1" /calculated_mol_wt="116951" Region 17..348 /region_name="STKc_Pat1_like" /note="Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; cd13993" /db_xref="CDD:270895" Site order(24..28,32,45,47,148,160..163,167,169,207,209, 211..212,214,226,229,242..245) /site_type="active" /db_xref="CDD:270895" Site order(24..28,32,45,47,148,160..163,167,207,209,211..212, 214,226) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270895" Site order(28,167,169,207,209,211,229,242..245) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270895" Site 225..245 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270895" CDS 1..1029 /gene="KSP1" /locus_tag="YHR082C" /coded_by="NM_001179212.1:1..3090" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8676864|PMID:18417610]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:18417610]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640|PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0016242 negative regulation of macroautophagy [PMID:22447937]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:18417610]" /experiment="EXISTENCE:mutant phenotype:GO:0010570 regulation of filamentous growth [PMID:18417610]" /experiment="EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:22447937]" /experiment="EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:22043304]" /experiment="EXISTENCE:mutant phenotype:GO:0043555 regulation of translation in response to stress [PMID:31455721]" /experiment="EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:22043304|PMID:31455721]" /experiment="EXISTENCE:physical interaction:GO:0031929 TOR signaling [PMID:22043304]" /note="Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856482" /db_xref="SGD:S000001124" ORIGIN 1 mtldyeiyke ggilnnryqk iedisegsyg yvslakdvre krlvavkyif kleddgqydg 61 pqddendcds sdcdddedtk vdtdrhenen gnassnngss rekkhnlykh kkslisskvk 121 srlsnnicle amyevdiqtk igrhqniaal ldffdsyiim eycsggdlye aikadavpkk 181 tksithiitq imdaieyvhn kgiyhrdikp enilisgidw tikltdwgla ttdktsmdrn 241 vgserymspe lfdsnldike rkepydcakv dlwamgivfl nivfhknpfs ianqsdksfc 301 yfaanrealf dvfstmaydf fqvlryslti dpanrdlkmm rtelqnlsey tlddeyynnl 361 degyeetmid glppqpvpps sapvslptpi sssnkqhmpe fkkdfnfnnv nerkrsdvsq 421 nqnvasgffk kpstqqqkff nqgynttlst heraksapkf kfkkrnkygr tdnqfskpvn 481 iedrkkskil kksrkplgip tpnthmnnff hdykardefn trdfftppsv qhrymegfsn 541 nnnkqyrqnr nynnnnnnsn nnhgsnynnf nngnsyikgw nknfnkyrrp ssssytgksp 601 lsrynmsynh nnnssingya rrgstttvqh spgayippna rnhhvsptnq flrvpqstap 661 distvlggkp syqehytqds mdsegdhdsd dvlftleegd hdfvngmdnl sindhlphtt 721 vgshnevfvh astnhnnngn nnhidtnstt nqyhrqyipp plttslhinn nnnesnelpd 781 llkspassea hlnlssgpid piltgnignr yshssdskel eqerrlsmeq kfkngvyvpp 841 hhrksfnlgt qvppmnmkts neatlsvshn svnfggsyns rrssanesnp lhmnkalekl 901 ssspgakssf vgfpkpllpr nhssttialq nedvfadsnn daiifedeey egesdkmahg 961 kmeggdness stspderqif gpyeiyaqtf agsthdkklg agrktsiqde mvgsleqykn 1021 nwlilqqqd // LOCUS NP_011951 329 aa linear PLN 30-JUN-2025 DEFINITION SAM complex subunit SAM35 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011951 VERSION NP_011951.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179213.1 REFERENCE 1 (residues 1 to 329) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 329) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 329) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 329) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06778. Method: conceptual translation. FEATURES Location/Qualifiers source 1..329 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..329 /product="SAM complex subunit SAM35" /calculated_mol_wt="37273" Region 5..133 /region_name="SAM35" /note="subunit of SAM coomplex; pfam10806" /db_xref="CDD:402440" CDS 1..329 /gene="SAM35" /locus_tag="YHR083W" /gene_synonym="FMP20; TOB38; TOM38" /coded_by="NM_001179213.1:1..990" /experiment="EXISTENCE:direct assay:GO:0001401 SAM complex [PMID:15067005|PMID:15205677]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:15205677|PMID:16407407|PMID:15067005]" /experiment="EXISTENCE:mutant phenotype:GO:0001401 SAM complex [PMID:15205677]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:15067005|PMID:18039934|PMID:15326197]" /experiment="EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:15067005|PMID:18039934|PMID:15205677]" /note="Component of the sorting and assembly machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane" /db_xref="GeneID:856483" /db_xref="SGD:S000001125" ORIGIN 1 mvssfsvpmp vkrifdtfpl qtyaaqtdkd eavaleiqrr sytfterggg sseltvegty 61 klgvynvfle antgaalatd pwclfvqlal cqknglvlpt hsqeqtpsht cnhemlvlsr 121 lsnpdealpi lvegykkrii rstvaiseim rsrilddaeq lmyytlldtv lydcwitqii 181 fcasdaqfme lyscqklsgs ivtpldvens llqklsaksl kisltkrnkf qfrhreivks 241 mqgvyhnhhn svnqeqvlnv lfenskqvll glkdmlksdg qptylhlkia syilcitnvk 301 epiklktfve neckelvqfa qdtlknfvq // LOCUS NP_011952 688 aa linear PLN 30-JUN-2025 DEFINITION homeodomain family transcription factor STE12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011952 VERSION NP_011952.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179214.1 REFERENCE 1 (residues 1 to 688) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 688) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 688) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 688) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06779. Method: conceptual translation. FEATURES Location/Qualifiers source 1..688 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..688 /product="homeodomain family transcription factor STE12" /calculated_mol_wt="77736" Region 58..167 /region_name="STE" /note="STE like transcription factor; pfam02200" /db_xref="CDD:366975" CDS 1..688 /gene="STE12" /locus_tag="YHR084W" /coded_by="NM_001179214.1:1..2067" /experiment="EXISTENCE:direct assay:GO:0000747 conjugation with cellular fusion [PMID:3931921]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:2558054]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19159085]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:20852627]" /experiment="EXISTENCE:direct assay:GO:1990526 Ste12p-Dig1p-Dig2p complex [PMID:16782869]" /experiment="EXISTENCE:direct assay:GO:1990527 Tec1p-Ste12p-Dig1p complex [PMID:16782869]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16940175]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:8001818]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077|PMID:8259520]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7834739]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:7834739|PMID:16940175]" /note="Transcription factor that is activated by a MAPK signaling cascade; activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth" /db_xref="GeneID:856484" /db_xref="SGD:S000001126" ORIGIN 1 mkvqitnsrt eeilkvqann endevskatp geveeslrli gdlkfflata pvnwqenqii 61 rryylnsgqg fvscvfwnnl yyitgtdivk cclyrmqkfg revvqkkkfe egifsdlrnl 121 kcgidatleq pkseflsflf rnmclktqkk qkvffwfsva hdklfadale rdlkreslnq 181 psttkpvnep alsfsydsss dkplydqllq hldsrrpsst tksdnsppkl esenfkdnel 241 vtvtnqpllg vglmdddape spsqindfip qkliiepntl elnglteetp hdlpkntakg 301 rdeedfpldy fpvsveypte enafdpfppq aftpaapsmp isydnvnerd smpvnsllnr 361 ypyqlsvapt fpvppsssrq hfmtnrdfys snnnkeklvs psdptsymky depvmdfdes 421 rpnenctnak shnsgqqtkq hqlysnnfqq sypngmvpgy ypkmpynpmg gdplldqafy 481 gaddfffppe gcdnnmlypq tatswnvlpp qamqpaptyv grpytpnyrs tpgsamfpym 541 qssnsmqwnt avspyssrap sttaknypps tfysqninqy prrrtvgmks sqgnvptgnk 601 qsvgksakis kplhiktsay qkqykinlet karpsagded sahpdknkei smptpdsntl 661 vvqseeggah slevdtnrrs dknlpdat // LOCUS NP_011953 334 aa linear PLN 30-JUN-2025 DEFINITION Ipi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011953 VERSION NP_011953.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179215.1 REFERENCE 1 (residues 1 to 334) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 334) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 334) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 334) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06780. Method: conceptual translation. FEATURES Location/Qualifiers source 1..334 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..334 /product="Ipi1p" /calculated_mol_wt="37736" Region 125..216 /region_name="Ipi1_N" /note="Rix1 complex component involved in 60S ribosome maturation; pfam12333" /db_xref="CDD:463535" CDS 1..334 /gene="IPI1" /locus_tag="YHR085W" /coded_by="NM_001179215.1:1..1005" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:22421151]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15528184]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0120330 rixosome complex [PMID:14759368]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15528184]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12089522]" /experiment="EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:22421151]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:14759368]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:22421151]" /note="Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene" /db_xref="GeneID:856485" /db_xref="SGD:S000001127" ORIGIN 1 mtksrkqkqk kqdflrkklk vgkpkekarn atdtsfvskt isirnqhldq nphdltkrlt 61 llkhhninvr ketlttfqks ipsiiksrlm tplltqsipl icdesqqvrq glidlvdeig 121 shdaeilklh cnifvlyinm amthivtqiq adstkflshl lkycgdevvr kswvkllngv 181 fgvlgwgqvg kndsasivqt kkrnakyvti hlnalytlve ygcqderars dgdtaetted 241 sgtlrnpyli pdypqpfehl klftrelkvq datssgvnat llslatqdid trkavfieqf 301 lpivrkkiev iikeggecgk sanklktlla kifd // LOCUS NP_011954 523 aa linear PLN 30-JUN-2025 DEFINITION Nam8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011954 VERSION NP_011954.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179216.1 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 523) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06781. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..523 /product="Nam8p" /calculated_mol_wt="56841" Region 55..144 /region_name="RRM1_NGR1_NAM8_like" /note="RNA recognition motif 1 (RRM1) found in yeast negative growth regulatory protein NGR1, yeast protein NAM8 and similar proteins; cd12611" /db_xref="CDD:410023" Region 162..241 /region_name="RRM2_SECp43_like" /note="RNA recognition motif 2 (RRM2) found in tRNA selenocysteine-associated protein 1 (SECp43) and similar proteins; cd12345" /db_xref="CDD:409781" Region 312..383 /region_name="RRM3_NGR1_NAM8_like" /note="RNA recognition motif 3 (RRM3) found in yeast negative growth regulatory protein NGR1 (RBP1), yeast protein NAM8 and similar proteins; cd12346" /db_xref="CDD:409782" CDS 1..523 /gene="NAM8" /locus_tag="YHR086W" /gene_synonym="MRE2; MUD15" /coded_by="NM_001179216.1:1..1572" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:mutant phenotype:GO:0006376 mRNA splice site recognition [PMID:10072385]" /experiment="EXISTENCE:mutant phenotype:GO:0048026 positive regulation of mRNA splicing, via spliceosome [PMID:10983980]" /experiment="EXISTENCE:physical interaction:GO:0000243 commitment complex [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0003729 mRNA binding [PMID:10072386]" /note="RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function" /db_xref="GeneID:856486" /db_xref="SGD:S000001128" ORIGIN 1 msykqttyyp srgnlvrnds spytntisse tnnsstsvls lqgasnvslg ttgnqlymgd 61 ldptwdkntv rqiwaslgea ninvrmmwnn tlnngsrssm gpknnqgycf vdfpssthaa 121 nallkngmli pnfpnkklkl nwatssysns nnslnnvksg nncsifvgdl apnvtesqlf 181 elfinryast shakivhdqv tgmskgygfv kftnsdeqql alsemqgvfl ngraikvgpt 241 sgqqqhvsgn ndynrssssl nnenvdsrfl skgqsflsng nnnmgfkrnh msqfiypvqq 301 qpslnhftdp nnttvfiggl sslvtedelr ayfqpfgtiv yvkipvgkcc gfvqyvdrls 361 aeaaiagmqg fpiansrvrl swgrsakqta llqqamlsns lqvqqqqpgl qqpnygyips 421 stceapvlpd nnvsstmlpg cqilnysnpy ananglgsnn fsfysnnnat ntqatsllad 481 tssmdlsgtg gqqvimqgse avvnstnaml nrleqgsngf mfa // LOCUS NP_878089 53 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR086W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878089 VERSION NP_878089.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184553.1 REFERENCE 1 (residues 1 to 53) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 53) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 53) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 53) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06782. Method: conceptual translation. FEATURES Location/Qualifiers source 1..53 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..53 /product="uncharacterized protein" /calculated_mol_wt="5854" CDS 1..53 /locus_tag="YHR086W-A" /coded_by="NM_001184553.1:1..162" /note="hypothetical protein; identified by fungal homology and RT-PCR; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /db_xref="GeneID:1466529" /db_xref="SGD:S000028552" ORIGIN 1 mrlslysccl cigarriptp clfsyiftpn lahfhsplrs sgfrpagatr fys // LOCUS NP_011955 111 aa linear PLN 30-JUN-2025 DEFINITION Rtc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011955 VERSION NP_011955.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179217.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 111) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06783. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..111 /product="Rtc3p" /calculated_mol_wt="11878" Region 6..95 /region_name="SBDS" /note="Shwachman-Bodian-Diamond syndrome (SBDS) protein; pfam01172" /db_xref="CDD:460097" CDS 1..111 /gene="RTC3" /locus_tag="YHR087W" /gene_synonym="HGI1" /coded_by="NM_001179217.1:1..336" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0016070 RNA metabolic process [PMID:15701634]" /note="hypothetical protein involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog is SDO1); null mutation suppresses cdc13-1 temperature sensitivity; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856487" /db_xref="SGD:S000001129" ORIGIN 1 mstvtkyfyk gentdlivfa aseelvdeyl knpsigklse vvelfevftp qdgrgaegel 61 gaaskaqven efgkgkkiee vidlilrngk pnsttsslkt kggnagtkay n // LOCUS NP_011956 295 aa linear PLN 30-JUN-2025 DEFINITION rRNA-binding ribosome biosynthesis protein RPF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011956 VERSION NP_011956.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179218.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 295) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06784. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..295 /product="rRNA-binding ribosome biosynthesis protein RPF1" /calculated_mol_wt="34990" Region 96..265 /region_name="Brix" /note="The Brix domain is found in a number of eukaryotic proteins; smart00879" /db_xref="CDD:214879" CDS 1..295 /gene="RPF1" /locus_tag="YHR088W" /coded_by="NM_001179218.1:1..888" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11864606]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:11864606]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:16581791]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11864606]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11864606]" /note="Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA" /db_xref="GeneID:856488" /db_xref="SGD:S000001130" ORIGIN 1 malgneinit nklkrqeifa dikheknker htmrrkrake erenpelreq rlkenvtqti 61 entrvydeti nkevegdedd lmryfnsnsn eppkiflttn vnakksayef anilieilpn 121 vtfvkrkfgy klkeisdici krnftdivii nedkkkvtgl tfihlpegpt fyfklssfve 181 vkkivghgrp tshipeliln nfqtrlgqtv grlfqsilpq npdiegrqvi tlhnqrdyif 241 frrhryvfkd nervglqelg pqftlklkrl qrgikeetew ehkpemdkek kkfyl // LOCUS NP_011957 205 aa linear PLN 30-JUN-2025 DEFINITION H/ACA snoRNP pseudouridylase subunit GAR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011957 VERSION NP_011957.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179219.1 REFERENCE 1 (residues 1 to 205) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 205) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 205) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 205) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06785. Method: conceptual translation. FEATURES Location/Qualifiers source 1..205 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..205 /product="H/ACA snoRNP pseudouridylase subunit GAR1" /calculated_mol_wt="21349" Region 37..123 /region_name="Gar1" /note="Gar1/Naf1 RNA binding region; pfam04410" /db_xref="CDD:461296" CDS 1..205 /gene="GAR1" /locus_tag="YHR089C" /coded_by="NM_001179219.1:1..618" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:1531632]" /experiment="EXISTENCE:direct assay:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]" /experiment="EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:2898766]" /experiment="EXISTENCE:physical interaction:GO:0034513 box H/ACA snoRNA binding [PMID:9556561]" /note="Protein component of the H/ACA snoRNP pseudouridylase complex; involved in the modification and cleavage of the 18S pre-rRNA" /db_xref="GeneID:856489" /db_xref="SGD:S000001131" ORIGIN 1 msfrggnrgg rggfrggfrg grtgsarsfq qgppdtvlem gaflhpcegd ivcrsintki 61 pyfnapiyle nktqvgkvde ilgplnevff tikcgdgvqa tsfkegdkfy iaadkllpie 121 rflpkpkvvg ppkpknkkkr sgapggrgga smgrggsrgg frggrggssf rggrggssfr 181 ggsrggsfrg gsrggsrggf rggrr // LOCUS NP_011958 282 aa linear PLN 30-JUN-2025 DEFINITION histone acetyltransferase YNG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011958 VERSION NP_011958.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179220.1 REFERENCE 1 (residues 1 to 282) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 282) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 282) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 282) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06786. Method: conceptual translation. FEATURES Location/Qualifiers source 1..282 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..282 /product="histone acetyltransferase YNG2" /calculated_mol_wt="31955" Region 1..272 /region_name="TNG2" /note="Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]; COG5034" /db_xref="CDD:227367" CDS 1..282 /gene="YNG2" /locus_tag="YHR090C" /gene_synonym="EAF4; NBN1" /coded_by="NM_001179220.1:1..849" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:17274630]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:10805724]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0032777 piccolo histone acetyltransferase complex [PMID:12782659]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:17142463]" /note="Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5" /db_xref="GeneID:856490" /db_xref="SGD:S000001132" ORIGIN 1 mdpslvleqt iqdvsnlpse frylleeigs ndlklieekk kyeqkesqih kfirqqgsip 61 khpqedgldk eikesllkcq slqrekcvla ntalfliarh lnkleknial leedgvlapv 121 eedgdmdsaa easressvvs nssvkkrraa sssgsvpptl kkkktsrtsk lqneidvssr 181 eksvtpvsps iekkiartke fknsrngkgq ngspeneeed ktlycfcqrv sfgemvacdg 241 pnckyewfhy dcvnlkeppk gtwycpecki emeknklkrk rn // LOCUS NP_011959 643 aa linear PLN 30-JUN-2025 DEFINITION arginine--tRNA ligase MSR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011959 VERSION NP_011959.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179221.1 REFERENCE 1 (residues 1 to 643) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 643) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 643) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 643) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06787. Method: conceptual translation. FEATURES Location/Qualifiers source 1..643 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..643 /product="arginine--tRNA ligase MSR1" /EC_number="6.1.1.19" /calculated_mol_wt="73563" Region 69..643 /region_name="argS" /note="arginyl-tRNA synthetase; TIGR00456" /db_xref="CDD:273085" CDS 1..643 /gene="MSR1" /locus_tag="YHR091C" /coded_by="NM_001179221.1:1..1932" /experiment="EXISTENCE:curator inference:GO:0070144 mitochondrial arginyl-tRNA aminoacylation [PMID:7607232]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:7607232]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:7607232]" /note="Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication" /db_xref="GeneID:856491" /db_xref="SGD:S000001133" ORIGIN 1 mfgivylknr sllcknpfss yprygfmpsf dtqfsnqfrk leinigrkry ssktlntkyt 61 dqpegpiypl dvlrldiska lhdisgidhs lilnalestn smdrgdlllp lpkikvadpv 121 avanrwaiel sthgcigkvc akgpflqffl dqryliqstv pnillqkgky gqkksrhqkk 181 vvvefsspni akpfhaghlr stiiggflsn lyeamgwsvt rmnylgdwgr qfgllavgfk 241 rygdektlqk qpiqhlfdvy vkinmdlake eingnskcgi sgearsffkn lengdenaik 301 iwnrfrslsi hhyiqtysrl ninfdifsge sqvskesmne aldifrknnl vkeidgalvi 361 dltqwskrlg rvvvqksdgt tlyltrdvga aierkknlhf dkmvyvissq qdlymsqffm 421 ilkkmnfewa kdlqhinfgm vqgmstrkgn vvfldtilde ardkalqime nnkmkisqvd 481 npqrvadlig vsaiiiqdmk skrinnyefn wnrmlsfegd tgpylqyths rlrslertss 541 dfttdmliha dfsnlnepql velvrllaqy pdvlrrafet qepativtyl fkvchqvssc 601 ykkiwvsgkp adiaiprlav ysasrqvlhn amsllglvpv drm // LOCUS NP_011960 576 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011960 VERSION NP_011960.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179222.2 REFERENCE 1 (residues 1 to 576) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 576) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 576) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 576) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06788. On Apr 26, 2011 this sequence version replaced NP_011960.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..576 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..576 /product="hexose transporter HXT4" /calculated_mol_wt="63779" Region 74..534 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(85,89,215,218..219,222,341..342,346..347,350..351, 376,446..447,450..451,455,478..479,482) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..576 /gene="HXT4" /locus_tag="YHR092C" /gene_synonym="LGT1; RAG1" /coded_by="NM_001179222.2:1..1731" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17507646|PMID:24124599]" /experiment="EXISTENCE:direct assay:GO:0055056 D-glucose transmembrane transporter activity [PMID:12702270]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015146 pentose transmembrane transporter activity [PMID:17180689]" /note="High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication" /db_xref="GeneID:856492" /db_xref="SGD:S000001134" ORIGIN 1 mseeaayqed tavqntpada lspvesdsns alstpsnkae rddmkdfden heesnnyvei 61 pkkpasayvt vsicclmvaf ggfvfgwdtg tisgfvaqtd firrfgmkhh dgtyylskvr 121 tglivsifni gcaiggiila klgdmygrkm glivvvviyi igiiiqiasi nkwyqyfigr 181 iisglgvggi avlspmlise vspkhirgtl vscyqlmitl giflgyctny gtktytnsvq 241 wrvplglgfa walfmiggmt fvpesprylv evgkieeakr sialsnkvsa ddpavmaeve 301 vvqatveaek lagnaswgei fstktkvfqr limgamiqsl qqltgdnyff yygttvftav 361 gledsfetsi vlgivnfast fvgiflvery grrrcllwga asmtacmvvf asvgvtrlwp 421 ngkkngsskg agncmivftc fylfcfattw apipfvvnse tfplrvkskc maiaqacnwi 481 wgfligfftp fisgaidfyy gyvfmgclvf syfyvfffvp etkgltleev ntlweegvlp 541 wkspswvppn krgtdynadd lmhddqpfyk kmfgkk // LOCUS NP_001335739 182 aa linear PLN 30-JUN-2025 DEFINITION Aht1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335739 VERSION NP_001335739.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348818.1 REFERENCE 1 (residues 1 to 182) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 182) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 182) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 182) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80259. Method: conceptual translation. FEATURES Location/Qualifiers source 1..182 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..182 /product="Aht1p" /calculated_mol_wt="19645" CDS 1..182 /gene="AHT1" /locus_tag="YHR093W" /coded_by="NM_001348818.1:1..549" /note="hypothetical protein; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region" /db_xref="GeneID:856493" /db_xref="SGD:S000001135" ORIGIN 1 mdckikaagk nsgifheggt kssksfltvf irsvfplsps fpagggiwgp mekkpggvgk 61 kkgsekktaq gniffsterd agqekcgily khcfsilygf fwkkadkpke ktgngsglgi 121 vfpigqkkip epadsdiflp cfryaaasdf tkakrflvei tavywvslea qpssasclfi 181 li // LOCUS NP_011962 570 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011962 VERSION NP_011962.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179224.1 REFERENCE 1 (residues 1 to 570) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 570) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 570) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 570) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06789. Method: conceptual translation. FEATURES Location/Qualifiers source 1..570 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..570 /product="hexose transporter HXT1" /calculated_mol_wt="63131" Region 68..528 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(79,83,209,212..213,216,335..336,340..341,344..345, 370,440..441,444..445,449,472..473,476) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..570 /gene="HXT1" /locus_tag="YHR094C" /gene_synonym="HOR4" /coded_by="NM_001179224.1:1..1713" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:24124599|PMID:10377429]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:7651133]" /experiment="EXISTENCE:mutant phenotype:GO:0015146 pentose transmembrane transporter activity [PMID:17180689]" /experiment="EXISTENCE:mutant phenotype:GO:0015761 mannose transmembrane transport [PMID:2046678]" /experiment="EXISTENCE:mutant phenotype:GO:1904659 D-glucose transmembrane transport [PMID:2046678]" /note="Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication" /db_xref="GeneID:856494" /db_xref="SGD:S000001136" ORIGIN 1 mnstpdlisp qksnssnsye lesgrskamn tpegknesfh dnlsesqvqp avappntgkg 61 vyvtvsiccv mvafggfifg wdtgtisgfv aqtdflrrfg mkhhdgshyl skvrtglivs 121 ifnigcaigg ivlaklgdmy grriglivvv viytigiiiq iasinkwyqy figriisglg 181 vggitvlspm lisevapsem rgtlvscyqv mitlgiflgy ctnfgtknys nsvqwrvplg 241 lcfawalfmi ggmmfvpesp rylveagrid earaslakvn kcppdhpyiq yeletieasv 301 eemraagtas wgelftgkpa mfqrtmmgim iqslqqltgd nyffyygtiv fqavglsdsf 361 etsivfgvvn ffstccslyt vdrfgrrncl mwgavgmvcc yvvyasvgvt rlwpngqdqp 421 sskgagncmi vfacfyifcf attwapiayv visecfplrv kskcmsiasa anwiwgflis 481 fftpfitgai nfyygyvfmg cmvfayfyvf ffvpetkgls leevndmyae gvlpwksasw 541 vpvskrgady naddlmhddq pfykslfsrk // LOCUS NP_011964 592 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011964 VERSION NP_011964.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179226.1 REFERENCE 1 (residues 1 to 592) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 592) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 592) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 592) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06790. Method: conceptual translation. FEATURES Location/Qualifiers source 1..592 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..592 /product="hexose transporter HXT5" /calculated_mol_wt="66121" Region 89..549 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(100,104,230,233..234,237,356..357,361..362,365..366, 391,461..462,465..466,470,493..494,497) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..592 /gene="HXT5" /locus_tag="YHR096C" /coded_by="NM_001179226.1:1..1779" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0055056 D-glucose transmembrane transporter activity [PMID:12702270]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490|PMID:20854260]" /experiment="EXISTENCE:mutant phenotype:GO:1904659 D-glucose transmembrane transport [PMID:20854260]" /note="Hexose transporter with moderate affinity for glucose; induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs; HXT5 has a paralog, HXT3, that arose from the whole genome duplication" /db_xref="GeneID:856496" /db_xref="SGD:S000001138" ORIGIN 1 mselenahqg plegsatvst nsnsyneksg nstapgtagy ndnlaqakpv ssyishegpp 61 kdeleelqke vdkqlekksk sdllfvsvcc lmvafggfvf gwdtgtisgf vrqtdfirrf 121 gstrangtty lsdvrtglmv sifnigcaig givlsklgdm ygrkiglmtv vviysigiii 181 qiasidkwyq yfigriisgl gvggitvlap mlisevspkq lrgtlvscyq lmitfgiflg 241 yctnfgtkny snsvqwrvpl glcfawsifm ivgmtfvpes prylvevgki eeakrslara 301 nkttedsplv tlemenyqss ieaerlagsa swgelvtgkp qmfrrtlmgm miqslqqltg 361 dnyffyygtt ifqavgleds fetaivlgvv nfvstffsly tvdrfgrrnc llwgcvgmic 421 cyvvyasvgv trlwpngqdq psskgagncm ivfacfyifc fattwapvay vlisesyplr 481 vrgkamsias acnwiwgfli sfftpfitsa infyygyvfm gcmvfayfyv fffvpetkgl 541 tleevnemye envlpwkstk wippsrrttd ydldatrndp rpfykrmftk ek // LOCUS NP_011965 366 aa linear PLN 30-JUN-2025 DEFINITION Pal2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011965 VERSION NP_011965.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179227.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 366) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06791. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..366 /product="Pal2p" /calculated_mol_wt="40532" Region 131..271 /region_name="Pal1" /note="Pal1 cell morphology protein; pfam08316" /db_xref="CDD:400558" CDS 1..366 /gene="PAL2" /locus_tag="YHR097C" /gene_synonym="SCD1" /coded_by="NM_001179227.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:30679249]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /note="Protein involved in clathrin-mediated endocytosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YHR097C has a paralog, PAL1, that arose from the whole genome duplication" /db_xref="GeneID:856497" /db_xref="SGD:S000001139" ORIGIN 1 mnqtgrtigg pqngvntvin pfrvspsedr vssrdetprn ynnpflnedd trrahnssvs 61 nsrqerlpsy eeaagtpkqq apypkekkrs sgsnshqhnh hhhrrtshgh rdkdkqksks 121 rtkvkppknv dtidkmdvtg lfggsfhhdg pfdactpqrn knnkvapvla fpadgpnntv 181 ggrtskkstl devfgretvd ddsetlnqlq draylfnkan sstttldaik pnsknitqfd 241 skmktelvhg pitmglgstt fldgapassa aieqdvinha qesrrknsia rkkslpsrrh 301 lqvnnnnlkl vkthsghleq kdvddnrtsv pvtatqgsgh edvvkkentg nkllrrvksl 361 ktskkh // LOCUS NP_011966 929 aa linear PLN 30-JUN-2025 DEFINITION Sfb3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011966 VERSION NP_011966.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179228.1 REFERENCE 1 (residues 1 to 929) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 929) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 929) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 929) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 929) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 929) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 929) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06792. Method: conceptual translation. FEATURES Location/Qualifiers source 1..929 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..929 /product="Sfb3p" /calculated_mol_wt="103820" Region 1..903 /region_name="COG5028" /note="Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]" /db_xref="CDD:227361" CDS 1..929 /gene="SFB3" /locus_tag="YHR098C" /gene_synonym="LST1" /coded_by="NM_001179228.1:1..2790" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:12426382|PMID:11086000]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0090110 COPII-coated vesicle cargo loading [PMID:12941277|PMID:12426382]" /experiment="EXISTENCE:mutant phenotype:GO:0090110 COPII-coated vesicle cargo loading [PMID:12941277]" /note="Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat; COPII coat is required for cargo selection during vesicle formation in ER to Golgi transport; scaffolding function of Lst1p required to generate vesicles that can accommodate difficult cargo proteins that include large oligomeric assemblies and asymmetrically distributed membrane proteins; with Atg40p acts in autophagy of the ER; homologous to Sec24p and Sfb2p" /db_xref="GeneID:856498" /db_xref="SGD:S000001140" ORIGIN 1 msqqnilaas vsalsldest vhtggasskk srrphrayhn fssgtvptlg nspyttpqln 61 qqdgfqqpqa ftpkqfggfn ngsgsvmstp vmvsqerfga seasspygqs mldmtapqpt 121 shivptqrfe dqaqylqrsf etcrdsvppl pttqfycvdq gscdphlmsl smynipeseh 181 lraatklplg ltiqpfstlt pndaevptip lpmdgtplrc rrcrayanpk fqftydssvi 241 cnicrvkmqv pgehfapmgp ngqrsdlnek sellhgtvdf lvpsiynaiq ekellplhyv 301 flidvsllan engsslamve gvrscieyis dfqpncevai ivydnklrff nlrpdldnaq 361 eyivselddv flpfynglfv kpgnsmkiin dtlikisgyi stdkyshvpq vcygsalqaa 421 klaldtvtgg qggkiicsln slptigngnl slkrdnahia hvkcdngfyk klasdflksy 481 isldlyvtna gfidmatvgh pvemtsgilk yyphfqqetd aftlvndmvt nvsnivgyqa 541 llkvrcstgl sveqyycdss dntdhdpiip vltrdttldv llkydskikt gtdvhfqtal 601 lytdidgvrk vrsintsgav snnireifkf inqnpvmrim ikdviktlgd cdfvkirrli 661 ddkmveiltq yrglvssnss tqlilpdsik tlpaymlafe kselmkpnaq strgneriyd 721 llkydslnsa qlcyklypqi vpfhvlleet dltfydandk llqinsssin nlsvrashsn 781 finggcylif qgdtiylwfn entnrmllqd llsvdeslpv sqislfsgtl petgtsinqk 841 asnviknwqq vvnksslplv llrpnvdqyy snvmsqllce dktvnriesy dnylvimhkk 901 iqeklqkddf ikvstaathe nihqkfvqf // LOCUS NP_011967 3744 aa linear PLN 30-JUN-2025 DEFINITION histone acetyltransferase TRA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011967 VERSION NP_011967.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179229.1 REFERENCE 1 (residues 1 to 3744) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 3744) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 3744) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 3744) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 3744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 3744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 3744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06793. Method: conceptual translation. FEATURES Location/Qualifiers source 1..3744 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..3744 /product="histone acetyltransferase TRA1" /calculated_mol_wt="433051" Region 290..935 /region_name="Tra1_central" /note="Tra1 HEAT repeat central region; pfam20175" /db_xref="CDD:466326" Region 947..2612 /region_name="Tra1_ring" /note="Tra1 HEAT repeat ring region; pfam20206" /db_xref="CDD:466357" Region 2757..3106 /region_name="FAT" /note="FAT domain; pfam02259" /db_xref="CDD:396714" Region 3371..3676 /region_name="PIKK_TRRAP" /note="Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; cd05163" /db_xref="CDD:270707" Region 3713..3744 /region_name="FATC" /note="FATC domain; pfam02260" /db_xref="CDD:460514" CDS 1..3744 /gene="TRA1" /locus_tag="YHR099W" /coded_by="NM_001179229.1:1..11235" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9885573]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18616809]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:direct assay:GO:0110078 TTT Hsp90 cochaperone complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20635087]" /note="Subunit of SAGA and NuA4 histone acetyltransferase complexes; subunit of the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation" /db_xref="GeneID:856499" /db_xref="SGD:S000001141" ORIGIN 1 mslteqieqf asrfrdddat lqsrystlse lydimellns pedyhfflqa viplllnqlk 61 evpisydahs peqklrnsml difnrclmnq tfqpyamevl efllsvlpke neengilcmk 121 vlttlfksfk silqdkldsf iriiiqiykn tpnlinqtfy eagkaeqgdl dspkepqade 181 lldefsknde ekdfpskqss teprfensts snglrssmfs fkilsecpit mvtlyssykq 241 ltstslpeft plimnllniq ikqqqeareq aesrgehfts isteiinrpa ycdfilaqik 301 atsflayvfi rgyapeflqd yvnfvpdlii rllqdcpsel ssarkellha trhilstnyk 361 klflpkldyl fderiligng ftmhetlrpl aystvadfih nirselqlse iektikiytg 421 ylldeslalt vqimsaklll nlverilklg kenpqeapra kkllmiiids ymnrfktlnr 481 qydtimkyyg ryethkkeka eklknsiqdn dkeseefmrk vlepsdddhl mpqpkkedin 541 dspdvemtes dkvvkndvem fdiknyapil llptptndpi kdafylyrtl msflktiihd 601 lkvfnpppne ytvanpklwa svsrvfsyee vivfkdlfhe ciiglkffkd hneklspett 661 kkhfdismps lpvsatkdar elmdylafmf mqmdnatfne iieqelpfvy ermledsgll 721 hvaqsfltse itspnfagil lrflkgklkd lgnvdfntsn vlirlfklsf msvnlfpnin 781 evvllphlnd lilnslkyst taeeplvyfy lirtlfrsig ggrfenlyrs ikpilqvllq 841 slnqmiltar lpherelyve lcitvpvrls vlapylpflm kplvfalqqy pdlvsqglrt 901 lelcidnlta eyfdpiiepv iddvskalfn llqpqpfnha ishnvvrilg klggrnrqfl 961 kpptdltekt eldidaiadf kingmpedvp lsvtpgiqsa lnilqsyksd ihyrksayky 1021 ltcvlllmtk ssaefptnyt ellktavnsi klerigiekn fdleptvnkr dysnqenlfl 1081 rllesvfyat sikelkddam dllnnlldhf cllqvnttll nkrnyngtfn idlknpnfml 1141 dsslildaip falsyyipev revgvlaykr iyekscliyg eelalshsfi pelakqfihl 1201 cydetyynkr ggvlgikvli dnvksssvfl kkyqynlang llfvlkdtqs eapsaitdsa 1261 ekllidllsi tfadvkeedl gnkvlentlt divcelsnan pkvrnacqks lhtisnltgi 1321 pivklmdhsk qfllspifak plralpftmq ignvdaitfc lslpntfltf neelfrllqe 1381 sivladaede slstniqktt eystseqlvq lriaciklla ialkneefat aqqgniriri 1441 lavffktmlk tspeiintty ealkgslaen sklpkellqn glkpllmnls dhqkltvpgl 1501 dalskllell iayfkveigr klldhltawc rvevldtlfg qdlaeqmptk iivsiinifh 1561 llppqadmfl ndlllkvmll erklrlqlds pfrtplaryl nrfhnpvtey fkknmtlrql 1621 vlfmcnivqr peakelaedf ekeldnfydf yisnipknqv rvvsfftnmv dlfntmvitn 1681 gdewlkkkgn milklkdmln ltlktikens fyidhlqlnq siakfqalyl rftelserdq 1741 npllldfidf sfsngikasy slkkfifhni iassnkekqn nfindatlfv lsdkcldari 1801 fvlknvinst liyevatsgs lksylvedkk pkwlellhnk iwknsnaila ydvldhhdlf 1861 rfellqlsai fikadpeiia eikkdiikfc wnfikledtl ikqsaylvts yfiskfdfpi 1921 kvvtqvfval lrsshveary lvkqsldvlt pvlhermnaa gtpdtwinwv krvmvensss 1981 qnnilyqfli shpdlffnsr dlfisniihh mnkitfmsns nsdshtlaid laslilywen 2041 ktleitnvnn tktdsdgdvv msdsksdinp veadttaiiv dannnspisl hlreactafl 2101 iryvcasnhr aietelglra inilselisd khwtnvnvkl vyfekflifq dldsenilyy 2161 cmnaldvlyv ffknktkewi menlptiqnl lekciksdhh dvqealqkvl qvimkaikaq 2221 gvsviieees pgktfiqmlt svitqdlqet ssvtagvtla wvlfmnfpdn ivplltplmk 2281 tfsklckdhl sisqpkdama leearittkl lekvlyilsl kvsllgdsrr pflstvalli 2341 dhsmdqnflr kivnmsrswi fnteifptvk ekaailtkml afeirgepsl sklfyeivlk 2401 lfdqehfnnt eitvrmeqpf lvgtrvedig irkrfmtild nslerdiker lyyvirdqnw 2461 efiadypwln qalqllygsf nrekelslkn iyclsppsil qeylpenaem vtevndlels 2521 nfvkghiasm qglcriissd fidslieify qdpkaihraw vtlfpqvyks ipknekygfv 2581 rsiitllskp yhtrqissrt nvinmlldsi skieslelpp hlvkylaisy nawyqsinil 2641 esiqsntsid ntkiieaned allelyvnlq eedmfyglwr rrakytetni glsyeqiglw 2701 dkaqqlyeva qvkarsgalp ysqseyalwe dnwiqcaekl qhwdvltela khegftdlll 2761 ecgwrvadwn sdrdaleqsv ksvmdvptpr rqmfktflal qnfaesrkgd qevrklcdeg 2821 iqlslikwvs lpirytpahk wllhgfqqym efleatqiya nlhtttvqnl dskaqeikri 2881 lqawrdrlpn twddvnmwnd lvtwrqhafq vinnaylpli palqqsnsns ninthayrgy 2941 heiawvinrf ahvarkhnmp dvcisqlari ytlpnieiqe aflklreqak chyqnmnelt 3001 tgldvisntn lvyfgtvqka efftlkgmfl sklrayeean qafatavqid lnlakawaqw 3061 gffndrrlse epnnisfasn aiscylqaag lyknskirel lcrilwlisi ddasgmltna 3121 fdsfrgeipv wywitfipql ltslshkean mvrhiliria ksypqalhfq lrttkedfav 3181 iqrqtmavmg dkpdtndrng rrqpweylqe lnnilktayp llalsleslv aqindrfkst 3241 tdedlfrlin vllidgtlny nrlpfprknp klpenteknl vkfsttllap yirpkfnadf 3301 idnkpdyety ikrlrywrrr lenkldrask kenlevlcph lsnfhhqkfe dieipgqyll 3361 nkdnnvhfik iarflptvdf vrgthssyrr lmirghdgsv hsfavqypav rhsrreermf 3421 qlyrlfnksl sknvetrrrs iqfnlpiaip lspqvrimnd svsfttlhei hnefckkkgf 3481 dpddiqdfma dklnaahdda lpapdmtilk veifnsiqtm fvpsnvlkdh ftslftqfed 3541 fwlfrkqfas qyssfvfmsy mmminnrtph kihvdktsgn vftlemlpsr fpyervkpll 3601 knhdlslppd spifhnnepv pfrltpniqs ligdsalegi favnlftisr aliepdneln 3661 tylalfirde iiswfsnlhr piienpqlre mvqtnvdlii rkvaqlghln stptvttqfi 3721 ldcigsavsp rnlartdvnf mpwf // LOCUS NP_011968 185 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylglycerophosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011968 VERSION NP_011968.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179230.1 REFERENCE 1 (residues 1 to 185) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 185) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 185) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 185) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06794. Method: conceptual translation. FEATURES Location/Qualifiers source 1..185 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..185 /product="phosphatidylglycerophosphatase" /EC_number="3.1.3.27" /calculated_mol_wt="20814" Region 3..166 /region_name="PGP_phosphatase" /note="Mitochondrial PGP phosphatase; pfam09419" /db_xref="CDD:430598" CDS 1..185 /gene="GEP4" /locus_tag="YHR100C" /coded_by="NM_001179230.1:1..558" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:20485265]" /experiment="EXISTENCE:direct assay:GO:0008962 phosphatidylglycerophosphatase activity [PMID:20485265]" /experiment="EXISTENCE:genetic interaction:GO:0008962 phosphatidylglycerophosphatase activity [PMID:20485265]" /experiment="EXISTENCE:mutant phenotype:GO:0008962 phosphatidylglycerophosphatase activity [PMID:20485265]" /experiment="EXISTENCE:mutant phenotype:GO:0032049 cardiolipin biosynthetic process [PMID:20485265]" /note="Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase); dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT" /db_xref="GeneID:856500" /db_xref="SGD:S000001142" ORIGIN 1 mnisgtlntl rllynpslck pslvvptfnd lpipihdsik avvldkdnci afphddkiwp 61 dylqhwetlr skysnkalli vsntagsnsd kdysqaklle dktgipvlrh stkkpgchne 121 ildyfyrnkt itnpkevavv gdrlftdilm anlmgsygvw irdgvkvsan plskfekkly 181 nflgf // LOCUS NP_011969 335 aa linear PLN 30-JUN-2025 DEFINITION Big1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011969 VERSION NP_011969.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179231.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 335) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06795. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..335 /product="Big1p" /calculated_mol_wt="38938" CDS 1..335 /gene="BIG1" /locus_tag="YHR101C" /coded_by="NM_001179231.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12112232]" /experiment="EXISTENCE:genetic interaction:GO:0006078 (1->6)-beta-D-glucan biosynthetic process [PMID:12112232]" /experiment="EXISTENCE:genetic interaction:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:39259764]" /experiment="EXISTENCE:mutant phenotype:GO:0006078 (1->6)-beta-D-glucan biosynthetic process [PMID:12112232]" /experiment="EXISTENCE:mutant phenotype:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:39259764]" /experiment="EXISTENCE:physical interaction:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:39259764]" /note="Integral ER membrane protein; involved in the assembly and function of the V-ATPase; proposed role as a signaling component that regulates autophagy independent of TOR; required for biosynthesis of cell wall beta-1,6-glucan; functional homolog of human ATP6AP1; analogous follicular lymphoma-associated mutation induces autophagy" /db_xref="GeneID:856501" /db_xref="SGD:S000001143" ORIGIN 1 mqtvlkylll imcgsfcase elqnqtnvpa iffsykltpg ilkyqedydr avtlprdtfi 61 eaaekflgvc nadtyvfinq pglrkldfle fetefvslqr yirrsstaik fekvdllpqd 121 lyydlaefvk eycnvdqvln lrgnntedfq pfidsekrvi iieypklped tnerkeafrh 181 ydkylrtila qipspeqnvi ytslnpgttl ahesiipiqi fpdifdiksr vgeveqnnrv 241 ldvprlsfnd ytprfsepps eyvsifdsql iennrgllql iftilvgyil iqffftkkti 301 vdekitnkkd nvkqtspqll kkvqeiqkkp sqqvs // LOCUS NP_011970 1080 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase KIC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011970 VERSION NP_011970.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179232.1 REFERENCE 1 (residues 1 to 1080) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1080) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1080) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1080) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1080) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1080) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1080) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06796. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1080 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1080 /product="putative serine/threonine protein kinase KIC1" /EC_number="2.7.11.1" /calculated_mol_wt="116931" Region 21..295 /region_name="STKc_NAK1_like" /note="Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; cd06917" /db_xref="CDD:270822" Site order(29..33,37,50,52,83,99..102,105..106,109,144,146..149, 151,161..162,165,179..182,184,212,221) /site_type="active" /db_xref="CDD:270822" Site order(29..33,37,50,52,69,83,99..102,105..106,109,148..149, 151,162) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270822" Site order(32..33,144,146..148,165,179..182,184,212,221) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270822" Site order(161..172,174..184) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270822" CDS 1..1080 /gene="KIC1" /locus_tag="YHR102W" /gene_synonym="NRK1" /coded_by="NM_001179232.1:1..3243" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12972564]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:9813095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12972564]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12972564]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:12480907]" /note="Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; phosphorylates Cbk1p kinase after allosteric activation by Hym1p; part of the RAM network that regulates cellular polarity and morphogenesis" /db_xref="GeneID:856502" /db_xref="SGD:S000001144" ORIGIN 1 mttkpqnskq glaegemdvs slfkrtevig rgkfgvvykg ynvktgrvya ikvlnldsds 61 devedvqrei qflaslkqis nitryygsyl kdtslwiime hcaggslrsl lrpgkideky 121 igvimrellv alkcihkdnv ihrdikaanv litnegnvkl cdfgvaaqvn qtslrrqtma 181 gtpywmapev imegvyydtk vdiwslgitt yeiatgnppy cdvealramq liikskpprl 241 edrsystslk efialclded pkerlsaddl lkskfirahk atptsilkel isryllfrdk 301 nknkykiegs ipenepskps eapkpsqngg gdeaqksias ndneikrvne gdvemkwdfd 361 slsssdyiie nninldalae dnnewataqh dlfnyaypde dsyyfdptsh ntrpfvyqgt 421 tigkgypgti aqnstlnapv tnnytnskyp skmvagttnt sgthtagpmt sskrleskap 481 kqllelfedn eiitaendvn teapkisksi sslnagnssr ddfipsisne vngninnnkm 541 rphlpplssg nnyysqstpa lpllqtkfnk tskgpptsgl ttaptsieie ipeelpnsal 601 ptpasadpvl ipstkarsst vtagtpssss siqykspsnv prrltvsnnr pehcpstitn 661 qklgsavasn sgisstpnns nnynnntdse nsrgssgsnt anstqmgitn pgnvtklsth 721 kasspsrplf gvgtspnrkp agsptqnigh nsthtnlapp ptmkpmansk dnkdillqpl 781 nsipssstln tisgnssnnl tssnyfsnek egsrvngdfk rnnpnlklqm plptpvvrnk 841 lldpntatsq nnngmpgsag istneninqf gfntssasni pvsmtpisek hidfggkikr 901 sqsisnrkns sasehplnil gssvsgnvsg ignnnvgsnn nsgpnnsvpl santgnttik 961 ansttiatss saaasttapi sqqtipsgtq fnhilssaat aansvnslgf gmcpppqslq 1021 memfldlesf lpgkqrrvdr kpqvlkelen llqmfeeglp ciehalkeql istpikdneh // LOCUS NP_011971 852 aa linear PLN 30-JUN-2025 DEFINITION Sbe22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011971 VERSION NP_011971.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179233.1 REFERENCE 1 (residues 1 to 852) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 852) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 852) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 852) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06797. Method: conceptual translation. FEATURES Location/Qualifiers source 1..852 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..852 /product="Sbe22p" /calculated_mol_wt="96268" Region 14..852 /region_name="SBE2" /note="cell-wall formation; pfam17076" /db_xref="CDD:293681" CDS 1..852 /gene="SBE22" /locus_tag="YHR103W" /coded_by="NM_001179233.1:1..2559" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10679005]" /note="Protein involved in bud growth; involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; SBE22 has a paralog, SBE2, that arose from the whole genome duplication" /db_xref="GeneID:856503" /db_xref="SGD:S000001145" ORIGIN 1 mtsiqergts ahlhslkege asdrssemlp kqrsiigshv qrppsqttlg rsragsntmn 61 kvsgldiarr psenllsnmn csdngnggnm lnsfvnsalp ppkvnpaqtr rerpasnssi 121 gtkttevfss tsassslgdt sdegegsdad kskintfpsi lmekatqgrg adgngmrsas 181 nntiveattd gskmalqksm sfddtaaekt mnksrhsyqe qfsskksqss llnskqrsra 241 ksqtcsstgy nnssilktfg isskisnssd rieasslefn vpsqkplnck pltpsqkyrl 301 rkeqsemnlr ntikrkekfy dsqeqilelq egdvddsliw nvpmaslstn sflasakpdd 361 mnnlagkndl seytgglvnd nseisytkqn hrysnisfas ttsnaslldf nemptspipg 421 lnkvtdfqfi qdttkslasv ylhssnrlsr sklsertkss dflpielkea qnqgmedlil 481 vsenkldvvs hsrpswlppk drqekklher qinksmsvas ldqlgknkdr eeklirdetn 541 rqkyvllldr ditrnsslqs lskmvwdtpf sdetrstiys eilqsktrfi tknyiqpfhe 601 lqelltkmgd fpknkeieis qlietslrrk vsglhdicpd lmlllkiksi ssqgivtgde 661 llfhhflvse sfqnlglnei wnivnlvqmt cfndlckekf dakvlerkgv vagylsqnee 721 fkdefnteci nsttwwnile ridhklfmwi mdiivvnnsq syknspined efvnkdweyy 781 rskkvvinyk ilisfalnvl lnyhfgftdl rslcnvndqr fcipvfinde fvdadtvnav 841 fikkwahyyk kf // LOCUS NP_011972 327 aa linear PLN 30-JUN-2025 DEFINITION trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) [Saccharomyces cerevisiae S288C]. ACCESSION NP_011972 VERSION NP_011972.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179234.1 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 327) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06798. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..327 /product="trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))" /EC_number="1.1.1.21" /calculated_mol_wt="36988" Region 3..318 /region_name="AKR_SF" /note="Aldo-keto reductase (AKR) superfamily; cl00470" /db_xref="CDD:444925" Site order(19..21,44,49,78,111,170..171,192,218..224,259, 274..277,282,285..286) /site_type="active" /db_xref="CDD:381296" Site order(44,49,78,111) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381296" CDS 1..327 /gene="GRE3" /locus_tag="YHR104W" /coded_by="NM_001179234.1:1..984" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0004032 aldose reductase (NADPH) activity [PMID:11525399|PMID:11306085]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019568 arabinose catabolic process [PMID:12271459]" /experiment="EXISTENCE:direct assay:GO:0032866 D-xylose reductase (NADPH) activity [PMID:11481678]" /experiment="EXISTENCE:direct assay:GO:0042843 D-xylose catabolic process [PMID:12271459]" /experiment="EXISTENCE:direct assay:GO:0071470 cellular response to osmotic stress [PMID:11525399]" /experiment="EXISTENCE:genetic interaction:GO:0019388 galactose catabolic process [PMID:18811659]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:17919749]" /experiment="EXISTENCE:mutant phenotype:GO:0019568 arabinose catabolic process [PMID:12271459]" /experiment="EXISTENCE:mutant phenotype:GO:0032866 D-xylose reductase (NADPH) activity [PMID:11481678]" /experiment="EXISTENCE:mutant phenotype:GO:0042843 D-xylose catabolic process [PMID:12271459]" /note="Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by HOG pathway; overexpression allows xylose fermentation in strains expressing heterologous xylitol dehydrogenase and xylulokinase; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856504" /db_xref="SGD:S000001146" ORIGIN 1 msslvtlnng lkmplvglgc wkidkkvcan qiyeaiklgy rlfdgacdyg nekevgegir 61 kaiseglvsr kdifvvsklw nnfhhpdhvk lalkktlsdm gldyldlyyi hfpiafkyvp 121 feekyppgfy tgaddekkgh iteahvpiid tyraleecvd egliksigvs nfqgsliqdl 181 lrgcrikpva lqiehhpylt qehlvefckl hdiqvvayss fgpqsfiemd lqlakttptl 241 fendvikkvs qnhpgsttsq vllrwatqrg iavipksskk erllgnleie kkftlteqel 301 kdisalnani rfndpwtwld gkfptfa // LOCUS NP_011973 214 aa linear PLN 30-JUN-2025 DEFINITION Ypt35p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011973 VERSION NP_011973.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179235.1 REFERENCE 1 (residues 1 to 214) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 214) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 214) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 214) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06799. Method: conceptual translation. FEATURES Location/Qualifiers source 1..214 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..214 /product="Ypt35p" /calculated_mol_wt="24515" Region 73..209 /region_name="PX_YPT35" /note="The phosphoinositide binding Phox Homology domain of the fungal protein YPT35; cd07280" /db_xref="CDD:132813" Site order(122..124,155..156,178) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:132813" CDS 1..214 /gene="YPT35" /locus_tag="YHR105W" /coded_by="NM_001179235.1:1..645" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /note="Endosomal hypothetical protein; contains a phox (PX) homology domain; binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport" /db_xref="GeneID:856505" /db_xref="SGD:S000001147" ORIGIN 1 msdkisflpp epiqlldeds tepeldidsq qenegpisas nsndstshsn dcgatitrtr 61 prrsssinan fsfqkahvsd ctivngdhgt kfavwritvf lepnlkafaa kresykiqty 121 krysdfvrlr enlltrikta kpeklnclqi phlppsvqwy sswkyqevnl nkdwlakrqr 181 gleyflnhii lnsslvemtk diliqfleps krva // LOCUS NP_011974 342 aa linear PLN 30-JUN-2025 DEFINITION thioredoxin-disulfide reductase TRR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011974 VERSION NP_011974.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179236.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 342) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06800. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..342 /product="thioredoxin-disulfide reductase TRR2" /EC_number="1.8.1.9" /calculated_mol_wt="36956" Region 28..338 /region_name="TRX_reduct" /note="thioredoxin-disulfide reductase; TIGR01292" /db_xref="CDD:273540" CDS 1..342 /gene="TRR2" /locus_tag="YHR106W" /coded_by="NM_001179236.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0004791 thioredoxin-disulfide reductase (NADPH) activity [PMID:10037727]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10037727|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10037727]" /note="Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication" /db_xref="GeneID:856506" /db_xref="SGD:S000001148" ORIGIN 1 mikhivspfr tnfvgisksv lsrmihhkvt iigsgpaaht aaiylaraem kptlyegmma 61 ngiaaggqlt tttdienfpg fpeslsgsel mermrkqsak fgtniitetv skvdlsskpf 121 rlwtefneda epvttdaiil atgasakrmh lpgeetywqq gisacavcdg avpifrnkpl 181 avigggdsac eeaefltkya skvyilvrkd hfrasvimqr rieknpniiv lfntvaleak 241 gdgkllnmlr ikntksnven dlevnglfya ighspatdiv kgqvdeeetg yiktvpgssl 301 tsvpgffaag dvqdsryrqa vtsagsgcia aldaerylsa qe // LOCUS NP_011975 407 aa linear PLN 30-JUN-2025 DEFINITION septin CDC12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011975 VERSION NP_011975.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179237.1 REFERENCE 1 (residues 1 to 407) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 407) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 407) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06801. Method: conceptual translation. FEATURES Location/Qualifiers source 1..407 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..407 /product="septin CDC12" /calculated_mol_wt="46537" Region 16..404 /region_name="CDC3" /note="Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5019" /db_xref="CDD:227352" CDS 1..407 /gene="CDC12" /locus_tag="YHR107C" /gene_synonym="CLA10; PSL7" /coded_by="NM_001179237.1:1..1224" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:3316985]" /experiment="EXISTENCE:direct assay:GO:0000921 septin ring assembly [PMID:12636916]" /experiment="EXISTENCE:direct assay:GO:0001934 positive regulation of protein phosphorylation [PMID:14527412]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:14993234]" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:29321251|PMID:22144691|PMID:18550837]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:14597621]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:23345395]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005937 mating projection [PMID:18552279]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0031105 septin complex [PMID:18550837]" /experiment="EXISTENCE:direct assay:GO:0032160 septin filament array [PMID:15282341]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:4950437]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:14993234]" /experiment="EXISTENCE:mutant phenotype:GO:0030011 maintenance of cell polarity [PMID:10882120]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:9442111]" /experiment="EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:9864366]" /experiment="EXISTENCE:physical interaction:GO:0031105 septin complex [PMID:9813094]" /note="Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells" /db_xref="GeneID:856507" /db_xref="SGD:S000001149" ORIGIN 1 msaatataap vpppvgisnl pnqrykivne eggtftvmlc gesglgkttf intlfqtvlk 61 radgqqhrqe pirktveidi tralleekhf elrvnvidtp gfgdnvnnnk awqplvdfid 121 dqhdsymrqe qqpyrtkkfd lrvhavlyfi rptghglkpi dietmkrlst ranlipviak 181 adtltaqelq qfksrirqvi eaqeiriftp pldadskeda ksgsnpdsaa veharqliea 241 mpfaivgsek kfdngqgtqv varkypwglv eiendshcdf rklralllrt ylldlisttq 301 emhyetyrrl rleghentge gnedftlpai aparklshnp rykeeenalk kyftdqvkae 361 eqrfrqweqn ivnerirlng dleeiqgkvk kleeqvkslq vkkshlk // LOCUS NP_011976 585 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol 4-phosphate-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_011976 VERSION NP_011976.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179238.1 REFERENCE 1 (residues 1 to 585) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 585) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 585) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 585) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06802. Method: conceptual translation. FEATURES Location/Qualifiers source 1..585 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..585 /product="phosphatidylinositol 4-phosphate-binding protein" /calculated_mol_wt="64216" Region 26..164 /region_name="VHS_GGA_fungi" /note="VHS (Vps27/Hrs/STAM) domain of fungal GGA (Golgi-localized, Gamma-ear-containing, Arf-binding) proteins; cd16998" /db_xref="CDD:340795" Site order(27,31,36,66,70..71,73..76) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:340795" Site order(43..44,47,51,92..93) /site_type="other" /note="putative intraprotein/interprotein binding site [polypeptide binding]" /db_xref="CDD:340795" Site order(104..106,109,118..119,153,160,164) /site_type="other" /note="acidic-cluster-dileucine motif interaction site [polypeptide binding]" /db_xref="CDD:340795" Region 199..233 /region_name="GGA_N-GAT" /note="N-terminal extension of GAT domain; pfam18308" /db_xref="CDD:465702" Region 235..324 /region_name="GAT_GGA_fungi" /note="canonical GAT domain found in fungal ADP-ribosylation factor (Arf)-binding proteins (GGAs); cd14235" /db_xref="CDD:410583" Site order(246,249..250,253,256..257,266..267,269..270,273..274, 277) /site_type="other" /note="putative ubiquitin binding site [polypeptide binding]" /db_xref="CDD:410583" Region 475..583 /region_name="Alpha_adaptinC2" /note="Adaptin C-terminal domain; pfam02883" /db_xref="CDD:460735" CDS 1..585 /gene="GGA2" /locus_tag="YHR108W" /coded_by="NM_001179238.1:1..1758" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:10747088]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:15039776]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:18287542]" /experiment="EXISTENCE:genetic interaction:GO:0006896 Golgi to vacuole transport [PMID:10747088]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:15039776]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:10747088]" /experiment="EXISTENCE:mutant phenotype:GO:0043130 ubiquitin binding [PMID:19574226]" /experiment="EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:15039776]" /experiment="EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:18287542]" /note="Protein that regulates Arf1p and Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; K63-specific Ub chain binding receptor with moderate selectivity; homologous to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication" /db_xref="GeneID:856508" /db_xref="SGD:S000001150" ORIGIN 1 mshphshsiy lselpvrkpq algnpllrki qracrmslae pdlalnldia dyinekqgaa 61 prdaaialak linnreshva ifalslldvl vkncgypfhl qisrkeflne lvkrfpghpp 121 lryskiqrli ltaieewyqt ickhssyknd mgyirdmhrl lkykgyafpk isesdlavlk 181 psnqlktase iqkeqeiaqa akleelirrg kpedlreank lmkimagfke dnavqakqai 241 sselnklkrk adllnemles pdsqnwdnet tqelhsalkv aqpkfqkiie eeqeddalvq 301 dllkfndtvn qllekfnllk ngdsnaasqi hpshvsaplq qssgaltnei nlidfndlde 361 apsqgnnntn gtgtpaaaet svndllgdlt dlsisnpsta nqasfglggd ivlgssqpap 421 pvtttnnsnn tldllglstp qsptnsqavn ssgfdllmgf npttgtttap artlvnqspn 481 lkiefeisre snsviriksf ftnlssspis nlvfllavpk smslklqpqs snfmignakd 541 gisqegtien apanpskalk vkwkvnysvn stqaeetavf tlpnv // LOCUS NP_011977 585 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c lysine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011977 VERSION NP_011977.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179239.1 REFERENCE 1 (residues 1 to 585) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 585) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 585) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 585) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06803. Method: conceptual translation. FEATURES Location/Qualifiers source 1..585 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..585 /product="cytochrome c lysine N-methyltransferase" /EC_number="2.1.1.59" /calculated_mol_wt="68154" Region 28..288 /region_name="SET_LSMT" /note="SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; cd10527" /db_xref="CDD:380925" Site order(33..34,200..201,227..232,272,285,287) /site_type="other" /note="SAM binding site" /db_xref="CDD:380925" Site order(33..34,58,198..203,227..231,240,270..273) /site_type="active" /note="putative active site [active]" /db_xref="CDD:380925" CDS 1..585 /gene="CTM1" /locus_tag="YHR109W" /coded_by="NM_001179239.1:1..1758" /experiment="EXISTENCE:direct assay:GO:0000277 [cytochrome c]-lysine N-methyltransferase activity [PMID:10791961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10791961]" /experiment="EXISTENCE:direct assay:GO:0018022 peptidyl-lysine methylation [PMID:10791961]" /experiment="EXISTENCE:mutant phenotype:GO:0000277 [cytochrome c]-lysine N-methyltransferase activity [PMID:10791961]" /note="Cytochrome c lysine methyltransferase; trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth" /db_xref="GeneID:856509" /db_xref="SGD:S000001151" ORIGIN 1 meevfrfysn srnifihksl slkpstiddp ksgyglfvep skfkndelks etiqllripk 61 rctfnintll allgdedefs skeefqrtnd kikialreim ahpnfsvflt etnlliiyfm 121 ifqtirsrye ipeniqyyle nvlmsievet amdsienlat dyghypqifg lretlnlfke 181 lfhdvlnlsd ikhlysaiis rcleiperad tkseeftvhs tlvpivdfan hegtqknayf 241 didpsnndvl llldtkavqs eltkpievfi sysptedlfs mlvtygftpd frgnsqfwtv 301 sfdrcflrny dgpdkttnlr lfykwmhinp vvplvkyehn gktrwflndt tpefdmlllp 361 fipsiddgki arwaydstch lmftkihcli npeanehalm iaenyrslik ekesngddfi 421 nlpplawslr ykdtendcvr qrhicsedav avlkqeemqd stktksqfts ffrkflefrr 481 skiirptsds kvasilyqqe leiiadlaka idssstiffs dlnvtldtep erlpplrfld 541 dyieisadkq epspicedls yytpsrftdf fqeevsqyaa ffqdd // LOCUS NP_011978 212 aa linear PLN 30-JUN-2025 DEFINITION Erp5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011978 VERSION NP_011978.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179240.1 REFERENCE 1 (residues 1 to 212) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 212) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 212) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 212) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06804. Method: conceptual translation. FEATURES Location/Qualifiers source 1..212 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..212 /product="Erp5p" /calculated_mol_wt="24118" Region 21..206 /region_name="EMP24_GP25L" /note="emp24/gp25L/p24 family/GOLD; pfam01105" /db_xref="CDD:426051" CDS 1..212 /gene="ERP5" /locus_tag="YHR110W" /coded_by="NM_001179240.1:1..639" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Protein with similarity to Emp24p and Erv25p; member of the p24 family involved in ER to Golgi transport" /db_xref="GeneID:856510" /db_xref="SGD:S000001152" ORIGIN 1 mkynivhgic llfaitqavg avhfyaksge tkcfyehlsr gnlligdldl yvekdglfee 61 dpessltitv detfdndhrv lnqknshtgd vtftaldtge hrfcftpfys kksatlrvfi 121 eleignveal dskkkedmns lkgrvgqltq rlssirkeqd airekeaefr nqsesanski 181 mtwsvfqlli llgtcafqlr ylknffvkqk vv // LOCUS NP_011979 440 aa linear PLN 30-JUN-2025 DEFINITION Uba4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011979 VERSION NP_011979.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179241.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 440) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06805. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..440 /product="Uba4p" /calculated_mol_wt="49230" Region 46..279 /region_name="ThiF_MoeB_HesA_family" /note="ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; cd00757" /db_xref="CDD:238386" Site order(74,76,78,98,100,109,122,164,170) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238386" Site order(78,165..167,171,189..190,194,196,263,267,275, 277..278) /site_type="other" /note="substrate interface [chemical binding]" /db_xref="CDD:238386" Region 316..440 /region_name="RHOD_ThiF" /note="Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein...; cd01526" /db_xref="CDD:238784" Site 397 /site_type="active" /note="active site residue [active]" /db_xref="CDD:238784" CDS 1..440 /gene="UBA4" /locus_tag="YHR111W" /gene_synonym="YHR1" /coded_by="NM_001179241.1:1..1323" /experiment="EXISTENCE:direct assay:GO:0004792 thiosulfate-cyanide sulfurtransferase activity [PMID:19864628]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032447 protein urmylation [PMID:10713047]" /experiment="EXISTENCE:direct assay:GO:0042292 URM1 activating enzyme activity [PMID:10713047]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:14551258]" /experiment="EXISTENCE:genetic interaction:GO:0007114 cell budding [PMID:14551258]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:14551258]" /experiment="EXISTENCE:mutant phenotype:GO:0002143 tRNA wobble position uridine thiolation [PMID:18664566|PMID:19151091|PMID:19145231]" /experiment="EXISTENCE:mutant phenotype:GO:0016783 sulfurtransferase activity [PMID:19145231]" /experiment="EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14555475]" /experiment="EXISTENCE:mutant phenotype:GO:0034227 tRNA thio-modification [PMID:19145231]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:14555475]" /experiment="EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:22043304]" /note="E1-like protein that activates Urm1p before urmylation; also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p" /db_xref="GeneID:856511" /db_xref="SGD:S000001153" ORIGIN 1 mndyhledtt selealrlen aqlreqlakr edssrdypls leeyqrygrq miveetggva 61 gqvklkntkv lvvgagglgc palpylagag vgqigivdnd vvetsnlhrq vlhdssrvgm 121 lkcesarqyi tklnphinvv typvrlnssn afdifkgyny ildctdsplt rylvsdvavn 181 lgitvvsasg lgtegqltil nfnnigpcyr cfyptppppn avtscqeggv igpciglvgt 241 mmavetlkli lgiytnenfs pflmlysgfp qqslrtfkmr grqekclccg knrtitkeai 301 ekgeinyelf cgarnynvce pderisvdaf qriykddefl akhifldvrp shhyeishfp 361 eavnipiknl rdmngdlkkl qeklpsvekd snivilcryg ndsqlatrll kdkfgfsnvr 421 dvrggyfkyi ddidqtipky // LOCUS NP_011980 378 aa linear PLN 30-JUN-2025 DEFINITION putative cystathionine beta-lyase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011980 VERSION NP_011980.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179242.1 REFERENCE 1 (residues 1 to 378) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 378) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 378) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 378) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06806. Method: conceptual translation. FEATURES Location/Qualifiers source 1..378 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..378 /product="putative cystathionine beta-lyase" /calculated_mol_wt="42314" Region 20..372 /region_name="CGS_like" /note="Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and...; cd00614" /db_xref="CDD:99738" Site order(27..30,32..33,56,58,83..84,86..87,107,112,115,197, 205,207,224,234,236..237,318) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:99738" Site order(84..86,107,144,173,195,197..198,207) /site_type="active" /note="substrate-cofactor binding pocket [active]" /db_xref="CDD:99738" Site order(84..86,107,173,176,195,197..198) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99738" Site 198 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99738" CDS 1..378 /locus_tag="YHR112C" /coded_by="NM_001179242.1:1..1137" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21777356]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:21777356]" /note="hypothetical protein; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway" /db_xref="GeneID:856512" /db_xref="SGD:S000001154" ORIGIN 1 mvdlstalih gddkdnrvtd vappinvstt fryddddlip wterenldfm ekkpvysrla 61 hpnstrlesi fseildgyav iyssglaafy aamvhynpkk ifigqsyhgv raianiltrn 121 ygieqhpled iekcasegdi vhlespvnpy gtssdiesla rrahakgall ivdstfaspp 181 lqyawnfgad ivlysatkyf gghsdllsgv lvvkeeatsr qlkddriylg tnvanlesfm 241 llrslrtyem ritkqsenat klvrflsdhq sefdkvlkti yhsslqteef vkkqlvggyg 301 pvfaitlytk eqckqlplkl kyfhhatslg gieslvewra mtdpyidqtl irvsvgcesa 361 ndlikdlasa lkelqdaa // LOCUS NP_011981 490 aa linear PLN 30-JUN-2025 DEFINITION aspartyl aminopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011981 VERSION NP_011981.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179243.1 REFERENCE 1 (residues 1 to 490) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 490) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 490) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 490) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06807. Method: conceptual translation. FEATURES Location/Qualifiers source 1..490 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..490 /product="aspartyl aminopeptidase" /EC_number="3.4.11.21" /calculated_mol_wt="54043" Region 20..479 /region_name="M18_DAP" /note="M18 peptidase aspartyl aminopeptidase; cd05658" /db_xref="CDD:349908" Site order(97,273..274,308..309,362..363,365,390,397,430..431, 455..456) /site_type="active" /db_xref="CDD:349908" CDS 1..490 /gene="APE4" /locus_tag="YHR113W" /coded_by="NM_001179243.1:1..1473" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:21343297]" /experiment="EXISTENCE:direct assay:GO:0004177 aminopeptidase activity [PMID:16367759]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006508 proteolysis [PMID:15606766]" /note="Cytoplasmic aspartyl aminopeptidase with possible vacuole function; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via CVT pathway; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms 12-subunit homo-oligomer; M18 metalloprotease family" /db_xref="GeneID:856513" /db_xref="SGD:S000001155" ORIGIN 1 mfriqlrtms sktcksdypk efvsflnssh spyhtvhnik khlvsngfke lserdswagh 61 vaqkgkyfvt rngssiiafa vggkwepgnp iaitgahtds palrikpisk rvsekylqvg 121 vetyggaiwh swfdkdlgva grvfvkdakt gksiarlvdl nrpllkiptl aihldrdvnq 181 kfefnretql lpigglqedk teaktekein ngeftsikti vqrhhaellg liakelaidt 241 iediedfeli lydhnastlg gfndefvfsg rldnltscft smhgltlaad teidresgir 301 lmacfdheei gsssaqgads nflpnilerl silkgdgsdq tkplfhsail etsaksffls 361 sdvahavhpn yankyesqhk pllgggpvik inanqrymtn spglvlvkrl aeaakvplql 421 fvvandspcg stigpilask tgirtldlgn pvlsmhsire tggsadlefq iklfkeffer 481 ytsieseivv // LOCUS NP_011982 633 aa linear PLN 30-JUN-2025 DEFINITION Bzz1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011982 VERSION NP_011982.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179244.1 REFERENCE 1 (residues 1 to 633) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 633) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 633) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 633) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06808. Method: conceptual translation. FEATURES Location/Qualifiers source 1..633 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..633 /product="Bzz1p" /calculated_mol_wt="71040" Region 10..256 /region_name="BAR" /note="The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013" /db_xref="CDD:472257" Site order(14,17..18,22,24..25,28..29,31..32,42..43,45..46, 49..50,52..53,56,99,102..103,220,223..224,226,228,231..232, 234..235,238..239,242..243,245..246,249..250,252..253) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153271" Region 497..552 /region_name="SH3_CIP4_Bzz1_like" /note="Src Homology 3 domain of Cdc42-Interacting Protein 4, Bzz1 and similar domains; cd11777" /db_xref="CDD:212711" Site order(502,504,507,511,530..531,546,548..549) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212711" Region 581..631 /region_name="SH3_Bzz1_2" /note="Second Src Homology 3 domain of Bzz1 and similar domains; cd11778" /db_xref="CDD:212712" Site order(586,588,591,595,614..615,628,630..631) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212712" CDS 1..633 /gene="BZZ1" /locus_tag="YHR114W" /gene_synonym="LSB7" /coded_by="NM_001179244.1:1..1902" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:25620000]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16824951]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:12391157|PMID:16824951]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:16231105]" /experiment="EXISTENCE:genetic interaction:GO:0009651 response to salt stress [PMID:12391157]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:16824951]" /experiment="EXISTENCE:mutant phenotype:GO:0045010 actin nucleation [PMID:16824951]" /experiment="EXISTENCE:physical interaction:GO:0007015 actin filament organization [PMID:12391157]" /experiment="EXISTENCE:physical interaction:GO:0009651 response to salt stress [PMID:12391157]" /note="SH3 domain protein implicated in regulating actin polymerization; able to recruit actin polymerization machinery through its SH3 domains; colocalizes with cortical actin patches and Las17p; interacts with type I myosins" /db_xref="GeneID:856514" /db_xref="SGD:S000001156" ORIGIN 1 msadlsigne ikdsfkethk wvqnnlkwlk dieqfyrera klekdyserl srlsaeyfnk 61 ksstsvpisv gdtptttpgs ieaagvvawn eilsqtdmis kdhdqlstdf enhvanqlsg 121 lftkldmtls kingfnndmv nkkdniyhel ekakkdydea cstmemarnr ytkasndrnk 181 kkldekemem nkckneylik inqanrtkdk yyfqdvpevl dllqdvneak tlflndlwlk 241 aasvendlga nvskrlqaan svvkqnkpsl ntaifikhnl knwkepqdfv ykpspvwhdd 301 ekfavpssle vedlriklak aendynslqd ktqnelskls tlnkikhemk tnedninatk 361 fydtlkeyln vvspftshet lklqaevqie siqnnvpeey dlstdnidls ktkkksgifs 421 kfkhnilnvd skpssggstg ngnggplhit slfntsrrtr lgsapnnage dsdnnsirtt 481 stnntkkttq nssddgknkv lyayvqkddd eititpgdki slvardtgsg wtkinndttg 541 etglvpttyi rissaatvka ndrgpapevp pprrstlpvr tmeaiyayea qgddeisidp 601 gdiitvirgd dgsgwtygec dglkglfpts yck // LOCUS NP_011983 416 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-conjugating protein DMA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011983 VERSION NP_011983.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179245.1 REFERENCE 1 (residues 1 to 416) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 416) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 416) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 416) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06809. Method: conceptual translation. FEATURES Location/Qualifiers source 1..416 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..416 /product="ubiquitin-conjugating protein DMA1" /EC_number="2.3.2.27" /calculated_mol_wt="45967" Region 151..296 /region_name="FHA_DMA-like" /note="forkhead associated (FHA) domain found in Saccharomyces cerevisiae defective in mitotic arrest protein 1 (DMA1), 2 (DMA2) and similar proteins; cd22692" /db_xref="CDD:438744" Site order(192..193,220..221,223,241,243..244) /site_type="other" /note="putative phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438744" Region 325..371 /region_name="RING-H2_Dmap-like" /note="RING finger, H2 subclass, found in defective in mitotic arrest proteins (Dmap) and similar proteins; cd16458" /db_xref="CDD:319372" CDS 1..416 /gene="DMA1" /locus_tag="YHR115C" /gene_synonym="CHF1" /coded_by="NM_001179245.1:1..1251" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:18202552]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:23264631]" /experiment="EXISTENCE:direct assay:GO:0051865 protein autoubiquitination [PMID:18202552]" /experiment="EXISTENCE:genetic interaction:GO:0000132 establishment of mitotic spindle orientation [PMID:22570619|PMID:15146058]" /experiment="EXISTENCE:genetic interaction:GO:0000921 septin ring assembly [PMID:15146058|PMID:22570619]" /experiment="EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:21562220]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:15146058|PMID:22570619]" /experiment="EXISTENCE:genetic interaction:GO:0032186 cellular bud neck septin ring organization [PMID:22570619]" /experiment="EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:22570619]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:18202552]" /experiment="EXISTENCE:mutant phenotype:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:27449057]" /experiment="EXISTENCE:physical interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:27449057]" /note="Ubiquitin-protein ligase (E3); controls septin dynamics, spindle position checkpoint (SPOC) with ligase Dma2p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ubiquitinates cyclin Pcl1p; ortholog of human RNF8, similar to human Chfr; contains FHA, RING fingers; DMA1 has a paralog, DMA2, that arose from the whole genome duplication" /db_xref="GeneID:856515" /db_xref="SGD:S000001157" ORIGIN 1 mstntvpssp pnqtppaasg iatshdhtkf nnpirlpisi sltindtpnn nsnnnsvsng 61 lgilpsrtat slvvanngsa ngnvgataaa aatvetntap avnttksirh fiyppnqvnq 121 tefsldihlp pntslperid qstlkrrmdk hglfsirltp fidtsstsva nqglffdpii 181 rtagagsqii igrytervre aiskipdqyh pvvfkskvis rthgcfkvdd qgnwflkdvk 241 sssgtflnhq rlssasttsk dyllhdgdii qlgmdfrggt eeiyrcvkmk ielnkswklk 301 anafnkeals riknlqkltt gleqedcsic lnkikpcqai fispcahswh fhcvrrlvim 361 nypqfmcpnc rtncdlettl esesesefen ededepdiem didmeinnnl gvrlvd // LOCUS NP_011984 151 aa linear PLN 30-JUN-2025 DEFINITION Cox23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011984 VERSION NP_011984.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179246.1 REFERENCE 1 (residues 1 to 151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 151) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06810. Method: conceptual translation. FEATURES Location/Qualifiers source 1..151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..151 /product="Cox23p" /calculated_mol_wt="17187" Region 104..138 /region_name="CHCH" /note="CHCH domain; pfam06747" /db_xref="CDD:429096" CDS 1..151 /gene="COX23" /locus_tag="YHR116W" /coded_by="NM_001179246.1:1..456" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15145942|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15145942]" /experiment="EXISTENCE:mutant phenotype:GO:0033108 mitochondrial respiratory chain complex assembly [PMID:19703468]" /note="Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs" /db_xref="GeneID:856516" /db_xref="SGD:S000001158" ORIGIN 1 mekpsptrrq tsslstisng mtmtndnrdt tntnsgstss nnsqpsssst ppaasgpvtd 61 rtkvnyvpks ddpssfqyyp ddpenpvnky kfalkadsqy ydpceesskl sfqclerndy 121 drskcqeyfd ayreckkqwl tarrknrqqw e // LOCUS NP_011985 639 aa linear PLN 30-JUN-2025 DEFINITION protein channel TOM71 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011985 VERSION NP_011985.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179247.1 REFERENCE 1 (residues 1 to 639) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 639) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 639) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 639) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06811. Method: conceptual translation. FEATURES Location/Qualifiers source 1..639 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..639 /product="protein channel TOM71" /calculated_mol_wt="71725" Region 9..636 /region_name="3a0801s09" /note="mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); TIGR00990" /db_xref="CDD:273380" Region 127..155 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(128,131..132,135..136,138,162,165..166,169..170, 172..173,196,199..200,203..204,207) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 160..190 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 195..218 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 345..373 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 378..406 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(379,382..383,386..387,389,413,416..417,420..421, 423..424,447,450..451,454..455,458) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 411..441 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 446..471 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 480..508 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 513..559 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 564..588 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..639 /gene="TOM71" /locus_tag="YHR117W" /gene_synonym="TOM72" /coded_by="NM_001179247.1:1..1920" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:16689936|PMID:8663394]" /experiment="EXISTENCE:genetic interaction:GO:0006626 protein targeting to mitochondrion [PMID:18007655]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:18007655]" /note="Mitochondrial outer membrane protein; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins; unique role in the dual distribution of tail-anchored proteins between mitochondria and peroxisomes; TOM71 has a paralog, TOM70, that arose from the whole genome duplication" /db_xref="GeneID:856517" /db_xref="SGD:S000001159" ORIGIN 1 maensllrfi tknkvailat vsagtaavga yvyyqqikqq qqqqlkgtkd nrrqseafag 61 qnedeadlkd dgsvvsgsnk rkkkknkrkr nnkaksgegf dypslpngep diaqlkglsp 121 sqrqayavql knrgnhffta knfneaikyy qyaieldpne pvfysnisac yistgdlekv 181 iefttkalei kpdhskallr rasaneslgn ftdamfdlsv lslngdfdga siepmlernl 241 nkqamkvlne nlskdegrgs qvlpsntsla sffgifdshl evssvntssn ydtayallsd 301 alqrlysatd egylvandll tkstdmyhsl lsantvddpl renaalalcy tgifhflknn 361 lldaqvllqe sinlhptpns yiflaltlad kensqeffkf fqkavdlnpe ypptyyhrgq 421 myfilqdykn akedfqkaqs lnpenvypyi qlacllykqg kfteseaffn etklkfptlp 481 evptffaeil tdrgdfdtai kqydiakrle evqekihvgi gpligkatil arqssqdptq 541 ldeekfnaai klltkaceld prseqakigl aqlklqmeki deaielfeds ailartmdek 601 lqattfaeaa kiqkrlradp iisakmeltl aryrakgml // LOCUS NP_011986 435 aa linear PLN 30-JUN-2025 DEFINITION origin recognition complex subunit 6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011986 VERSION NP_011986.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179248.1 REFERENCE 1 (residues 1 to 435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 435) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06812. Method: conceptual translation. FEATURES Location/Qualifiers source 1..435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..435 /product="origin recognition complex subunit 6" /calculated_mol_wt="50165" Region 22..416 /region_name="ORC6" /note="Origin recognition complex subunit 6 (ORC6); pfam05460" /db_xref="CDD:368452" CDS 1..435 /gene="ORC6" /locus_tag="YHR118C" /coded_by="NM_001179248.1:1..1308" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]" /experiment="EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:17053779]" /note="Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutation in the human Orc6p is linked to Meier-Gorlin syndrome" /db_xref="GeneID:856518" /db_xref="SGD:S000001160" ORIGIN 1 msmqqvqhcv aevlrldpqe kpdwssgylk kltnatsily ntslnkvmlk qdeevarchi 61 cayiasqkmn ekhmpdlcyy idsiplepkk akhlmnlfrq slsnsspmkq fawtpspkkn 121 krspvknggr ftssdpkelr nqlfgtptkv rksqnndsfv ipelppmqtn espsitrrkl 181 afeededede eepgndglsl kshsnksitg trnvdsdeye nhesdptsee eplgvqesrs 241 grtkqnkavg kpqselktak alrkrgripn sllvkkyckm tteeiirlcn dfelprevay 301 kivdeynina srlvcpwqlv cglvlnctfi vfnerrrkdp ridhfivskm cslmltskvd 361 dviecvklvk eliigekwfr dlqiryddfd girydeiifr klgsmlqttn ilvtddqyni 421 wkkriemdla ltepl // LOCUS NP_011987 1080 aa linear PLN 30-JUN-2025 DEFINITION histone methyltransferase SET1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011987 VERSION NP_011987.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179249.1 REFERENCE 1 (residues 1 to 1080) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1080) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1080) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1080) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1080) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1080) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1080) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06813. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1080 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1080 /product="histone methyltransferase SET1" /EC_number="2.1.1.354" /calculated_mol_wt="123782" Region <11..>136 /region_name="AF-4" /note="AF-4 proto-oncoprotein N-terminal region; pfam05110" /db_xref="CDD:461550" Region 246..360 /region_name="RRM_scSet1p_like" /note="RNA recognition motif in budding yeast Saccharomyces cerevisiae SET domain-containing protein 1 (scSet1p) and similar proteins; cd12302" /db_xref="CDD:409743" Region 422..486 /region_name="SET_assoc" /note="Histone lysine methyltransferase SET associated; pfam11767" /db_xref="CDD:432058" Region 763..932 /region_name="N-SET" /note="COMPASS (Complex proteins associated with Set1p) component N; pfam11764" /db_xref="CDD:463344" Region 926..1076 /region_name="SET_SET1" /note="SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; cd20072" /db_xref="CDD:380998" Site order(947..950,967,993..998,1012..1017,1025..1027,1036, 1052..1057,1067..1070) /site_type="active" /note="putative active site [active]" /db_xref="CDD:380998" Site order(947..950,993,1013..1017,1054,1067..1070) /site_type="other" /note="putative SAM binding site" /db_xref="CDD:380998" Site order(1019,1068,1070,1075) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:380998" CDS 1..1080 /gene="SET1" /locus_tag="YHR119W" /gene_synonym="KMT2; YTX1" /coded_by="NM_001179249.1:1..3243" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:17898715]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:28483910|PMID:16787775]" /experiment="EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11742990|PMID:11805083]" /experiment="EXISTENCE:direct assay:GO:0045815 transcription initiation-coupled chromatin remodeling [PMID:17898715]" /experiment="EXISTENCE:direct assay:GO:0140946 histone H3K4 dimethyltransferase activity [PMID:17898715]" /experiment="EXISTENCE:direct assay:GO:0140999 histone H3K4 trimethyltransferase activity [PMID:17898715]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16959218]" /experiment="EXISTENCE:genetic interaction:GO:0016279 protein-lysine N-methyltransferase activity [PMID:16143104]" /experiment="EXISTENCE:genetic interaction:GO:0033554 cellular response to stress [PMID:16959218]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27325136]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:11742990|PMID:9398665|PMID:27911222]" /experiment="EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:16787775]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16959218]" /experiment="EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:16143104]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:17150765]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:9398665]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:9988274|PMID:9398665|PMID:11752412|PMID:11805083]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:16959218]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:32290544]" /experiment="EXISTENCE:mutant phenotype:GO:0042800 histone H3K4 methyltransferase activity [PMID:11742990|PMID:12845608|PMID:11805083|PMID:11752412]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27325136]" /experiment="EXISTENCE:mutant phenotype:GO:1902275 regulation of chromatin organization [PMID:27325136]" /experiment="EXISTENCE:mutant phenotype:GO:1903341 regulation of meiotic DNA double-strand break formation [PMID:23246437]" /experiment="EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11752412|PMID:11742990|PMID:11687631]" /note="Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain" /db_xref="GeneID:856519" /db_xref="SGD:S000001161" ORIGIN 1 msnyyrraha ssgsyrqpqe qpqysrsghy qysnghshqq yssqynqrrr ynhndgtrrr 61 ynddrphssn nastrqyyat nnsqsgpyvn kksdissrrg msqsrysnsn vhntlasssg 121 slptesalll qqrppsvlry ntdnlkskfh yfdpikgeff nkdkmlswka tdkefsetgy 181 yvvkelqdgq fkfkikhrhp eikasdprne ngimtsgkva thrkcrnsli llprisydry 241 slgpppscei vvypaqdstt tniqdisikn yfkkygeish feafndpnsa lplhvyliky 301 assdgkinda akaafsavrk hessgcfimg fkfevilnkh silnniiskf veinvkklqk 361 lqenlkkake keaenekake lqgkditlpk epkvdtlshs sgsekripyd llgvvnnrpv 421 lhvskifvak hrfcvedfky klrgyrcakf idhptgiyii fndiahaqtc snaesgnlti 481 msrsrripil ikfhlilprf qnrtrfnkss sssnstnvpi kyeskeefie atakqilkdl 541 ektlhvdikk rligptvfda ldhanfpell akrelkekek rqqiaskiae delkrkeeak 601 rdfdlfglyg gyaksnkrnl krhnslaldh tslkrkklsn gikpmahlln eetdskettp 661 lndegitrvs kehdeedenm tsssseeeee eapdkkfkse septtpesdh lhgikplvpd 721 qngssdvlda ssmykptate ipepvyppee ydlkysqtls smdlqnaikd eedmlilkql 781 lstytptvtp etsaaleyki wqsrrkvlee ekasdwqiel ngtlfdselq pgssfkaegf 841 rkiadklkin ylphrrrvhq plntvnihne rneytpelcq reessnkeps dsvpqevsss 901 rdnrasnrrf qqdieaqkaa igtesellsl nqlnkrkkpv mfarsaihnw glyaldsiaa 961 kemiieyvge rirqpvaemr ekrylkngig ssylfrvden tvidatkkgg iarfinhccd 1021 pnctakiikv ggrrriviya lrdiaaseel tydykferek ddeerlpclc gapnckgfln // LOCUS NP_011988 959 aa linear PLN 30-JUN-2025 DEFINITION mismatch repair ATPase MSH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011988 VERSION NP_011988.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179250.1 REFERENCE 1 (residues 1 to 959) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 959) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 959) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 959) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 959) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 959) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 959) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06814. Method: conceptual translation. FEATURES Location/Qualifiers source 1..959 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..959 /product="mismatch repair ATPase MSH1" /calculated_mol_wt="109278" Region 72..958 /region_name="PRK05399" /note="DNA mismatch repair protein MutS; Provisional" /db_xref="CDD:235444" CDS 1..959 /gene="MSH1" /locus_tag="YHR120W" /coded_by="NM_001179250.1:1..2880" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:7961998|PMID:14576278|PMID:24769239|PMID:16823961|PM ID:15611870]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:7961999]" /experiment="EXISTENCE:direct assay:GO:0032137 guanine/thymine mispair binding [PMID:7961998]" /experiment="EXISTENCE:direct assay:GO:0032139 dinucleotide insertion or deletion binding [PMID:7961998]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:1334021]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:1334021]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:15611870]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:15611870|PMID:1334021]" /experiment="EXISTENCE:mutant phenotype:GO:0043504 mitochondrial DNA repair [PMID:1334021]" /note="DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis" /db_xref="GeneID:856520" /db_xref="SGD:S000001162" ORIGIN 1 mkhffrlpta frpisrvslr ysstdtaqpk isklkisfnk isesnsekkd nlgsidtrnc 61 lstqqddkls stepskaslp pslqyvrdlm dlykdhvvlt qmgsfyelyf eqairyapel 121 nisltnrays hgkvpfagfp vhqlsrhlkm lvnncgysvt iaeqfkkkdv adneankfyr 181 rvtrivtpgt fideafenlr entyllnief pencmsqvad tslkvgicwc dvstgeifvq 241 qvylrdlvsa itriqpkeil lderllefhi esgtwypelv elkkffikyq kmpsqhrtie 301 sfyglfnlgg keaterqlki qfqtftqkel aalrntliyv snhlpdfsin fqipqrqlat 361 aimqidsrts talelhstvr dnnkkgslls sirrtvtpsg trllsqwlsg psldlkeikk 421 rqkivaffkd nrditetlrt mlkkvndlsr ilqkfsfgrg ealeliqmar slevsreirk 481 yllnntslmk atlksqitql teslnfeknl iddilkflne eelaksqdak qnadvtrmld 541 idvkdkkesn kdeifelrdf ivnpsfntkl rklhdtyqgv wqkkteynal lkgffvgdlg 601 aktftlkerq ngeyalhvtg tasslkkide lisksteyhg scfhilqkss qtrwlshkiw 661 tdlghelell nlkirneean iidlfkrkfi drsnevrqva ttlgyldtls sfavlanern 721 lvcpkvdesn klevvngrhl mveeglsars letftannce lakdnlwvit gpnmggkstf 781 lrqnaiivil aqigcfvpcs karvgivdkl fsrvgsaddl ynemstfmve mietsfilqg 841 aterslaild eigrgtsgke gisiayatlk yllennqcrt lfathfgqel kqiidnkcsk 901 gmsekvkfyq sgitdlggnn fcynhklkpg ictksdairv aelagfpmea lkeareilg // LOCUS NP_011989 187 aa linear PLN 30-JUN-2025 DEFINITION Lsm12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011989 VERSION NP_011989.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179251.1 REFERENCE 1 (residues 1 to 187) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 187) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 187) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 187) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06815. Method: conceptual translation. FEATURES Location/Qualifiers source 1..187 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..187 /product="Lsm12p" /calculated_mol_wt="21182" Region 80..170 /region_name="AD" /note="Anticodon-binding domain; smart00995" /db_xref="CDD:214962" CDS 1..187 /gene="LSM12" /locus_tag="YHR121W" /coded_by="NM_001179251.1:1..564" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:20368989]" /experiment="EXISTENCE:physical interaction:GO:0016070 RNA metabolic process [PMID:16702403]" /note="hypothetical protein that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:856521" /db_xref="SGD:S000001163" ORIGIN 1 msvsleqtlg frikvtnvld vvtegrlysf nssnntltiq ttkknqspqn fkvikctfik 61 hlevigdkps fnsfkkqqik psyvnverve kllkesvias kkkellrgkg vsaegqfifd 121 qifktigdtk wvakdiiild dvkvqppykv edikvlhegs nqsitliqri versweqleq 181 ddgrkgg // LOCUS NP_011990 231 aa linear PLN 30-JUN-2025 DEFINITION iron-sulfur cluster assembly protein CIA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011990 VERSION NP_011990.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179252.1 REFERENCE 1 (residues 1 to 231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 231) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06816. Method: conceptual translation. FEATURES Location/Qualifiers source 1..231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..231 /product="iron-sulfur cluster assembly protein CIA2" /calculated_mol_wt="25544" Region 1..231 /region_name="COG5133" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227462" CDS 1..231 /gene="CIA2" /locus_tag="YHR122W" /coded_by="NM_001179252.1:1..696" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0097361 cytosolic [4Fe-4S] assembly targeting complex [PMID:22678362]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:22678362]" /note="Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B" /db_xref="GeneID:856522" /db_xref="SGD:S000001164" ORIGIN 1 mseflnenpd ileenqlptr kedstkdlll ggfsneatle rrslllkidh slksqvlqdi 61 evldkllsir ippeltsded slpaesedes vagggkeeee pdlidaqeiy dliahisdpe 121 hplslgqlsv vnledidvhd sgnqnemaev vikitptith cslatliglg irvrlerslp 181 prfritillk kgthdsenqv nkqlndkerv aaaceneqll gvvskmlvtc k // LOCUS NP_011991 391 aa linear PLN 30-JUN-2025 DEFINITION bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011991 VERSION NP_011991.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179253.1 REFERENCE 1 (residues 1 to 391) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 391) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 391) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 391) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06817. Method: conceptual translation. FEATURES Location/Qualifiers source 1..391 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..391 /product="bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase" /EC_number="2.7.8.1" /EC_number="2.7.8.2" /calculated_mol_wt="44429" Region 1..389 /region_name="PRK10832" /note="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; cl00453" /db_xref="CDD:469774" CDS 1..391 /gene="EPT1" /locus_tag="YHR123W" /coded_by="NM_001179253.1:1..1176" /experiment="EXISTENCE:direct assay:GO:0004142 diacylglycerol cholinephosphotransferase activity [PMID:2848840]" /experiment="EXISTENCE:direct assay:GO:0004307 ethanolaminephosphotransferase activity [PMID:2848840]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:2848840]" /experiment="EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:2848840]" /experiment="EXISTENCE:mutant phenotype:GO:0004142 diacylglycerol cholinephosphotransferase activity [PMID:2848840]" /experiment="EXISTENCE:mutant phenotype:GO:0004307 ethanolaminephosphotransferase activity [PMID:2848840]" /experiment="EXISTENCE:mutant phenotype:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:2848840]" /experiment="EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:2848840]" /note="sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication" /db_xref="GeneID:856523" /db_xref="SGD:S000001165" ORIGIN 1 mgyfvpdshi enlksykyqs edrslvskyf lkpfwqrfch ifptwmapni itlsgfafiv 61 invltvfyyd pnlntdtprw tyfsyalgvf lyqtfdgcdg vharrinqsg plgelfdhsi 121 dainstlsif ifasetgmgf synlmlsqfa mltnfylstw eeyhthtlyl sefsgpvegi 181 livcvslilt giygkqviwh tylftitvgd kvidvdtldi vfslavfglv mnalsakrnv 241 dkyyrnstss annitqieqd saikgllpff ayyasiallv wmqpsfitls filsvgftga 301 ftvgriivch ltkqsfpmfn apmliplcqi vlykiclslw giesnkivfa lswlgfglsl 361 gvhimfmndi ihefteyldv yalsikrskl t // LOCUS NP_011992 627 aa linear PLN 30-JUN-2025 DEFINITION transcription factor NDT80 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011992 VERSION NP_011992.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179254.1 REFERENCE 1 (residues 1 to 627) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 627) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 627) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 627) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06818. Method: conceptual translation. FEATURES Location/Qualifiers source 1..627 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..627 /product="transcription factor NDT80" /calculated_mol_wt="71349" Region 105..334 /region_name="NDT80_PhoG" /note="NDT80 / PhoG like DNA-binding family; pfam05224" /db_xref="CDD:398753" CDS 1..627 /gene="NDT80" /locus_tag="YHR124W" /coded_by="NM_001179254.1:1..1884" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11035815]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:9660952]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:9660952]" /experiment="EXISTENCE:mutant phenotype:GO:0043934 sporulation [PMID:9660952]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9660952]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:8524222]" /note="Meiosis-specific transcription factor; required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)" /db_xref="GeneID:856524" /db_xref="SGD:S000001166" ORIGIN 1 mnementdpv lqddlvskye relsteqeed tpviltqlne dgttsnyfdk rklkiaprst 61 lqfkvgppfe lvrdycpvve shtgrtldlr iipridrgfd hideewvgyk rnyftlvstf 121 etancdldtf lkssfdllve dssvesrlrv qyfaikikak nddddteinl vqhtakrdkg 181 pqfcpsvcpl vpsplpkhqi ireasnvrni tkmkkydstf ylhrdhvnye eygvdsllfs 241 ypedsiqkva ryervqfass isvkkpsqqn khfslhvilg avvdpdtfhg enpgipydel 301 alkngskgmf vylqemktpp liirgrspsn yassqritvr tpssvnssqn stkrkmpsma 361 qplnesclna rpskrrskva lgapnsgasi spiksrqstp measkenedp ffrpnkrvet 421 lehiqnklga lknqcpdssl kypssssrgm egclekedlv ysssfsvnmk qielkparsf 481 ehenifkvgs lafkkinelp henyditiek ksmeqnylrp eigsrseckt sygnelslsn 541 isfsilpnsa enfhletalf pateedvprt fsriletgsf qnyyqkmdae nadrvyskgv 601 kliasgtlps gifnreelfe edsfyky // LOCUS NP_001335740 101 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR125W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335740 VERSION NP_001335740.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348824.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 101) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80260. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..101 /product="uncharacterized protein" /calculated_mol_wt="11754" CDS 1..101 /locus_tag="YHR125W" /coded_by="NM_001348824.1:1..306" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:856526" /db_xref="SGD:S000001167" ORIGIN 1 minaimigsc qtfntilcni smnnyhsnvq lssirlqycm kysltfslfy nstvtlkrqt 61 wrtliydvci wldtavirni iirqlvvtlv vyyhmvckni t // LOCUS NP_011994 159 aa linear PLN 30-JUN-2025 DEFINITION Ans1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_011994 VERSION NP_011994.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179256.1 REFERENCE 1 (residues 1 to 159) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 159) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 159) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 159) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06819. Method: conceptual translation. FEATURES Location/Qualifiers source 1..159 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..159 /product="Ans1p" /calculated_mol_wt="16504" Region 101..116 /region_name="PIR" /note="Yeast PIR protein repeat; pfam00399" /db_xref="CDD:395322" CDS 1..159 /gene="ANS1" /locus_tag="YHR126C" /coded_by="NM_001179256.1:1..480" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Putative GPI protein; SWAT-GFP and mCherry fusion proteins localize to the vacuole; transcription dependent upon Azf1p" /db_xref="GeneID:856527" /db_xref="SGD:S000001168" ORIGIN 1 mkctlvstlf aitnilvaha qvsnssdtld vqfanstnsy iegkfnstde afnssaswsl 61 aaqqkkisna avydvggwng slyrsnrsav adhqpgkkqd aaisqisdgq iqatasgpet 121 taattpssta nvsvyegagm kvesknmgyi vgvaallfl // LOCUS NP_011995 243 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR127W [Saccharomyces cerevisiae S288C]. ACCESSION NP_011995 VERSION NP_011995.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179257.1 REFERENCE 1 (residues 1 to 243) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 243) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 243) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 243) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06820. Method: conceptual translation. FEATURES Location/Qualifiers source 1..243 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..243 /product="uncharacterized protein" /calculated_mol_wt="27001" CDS 1..243 /locus_tag="YHR127W" /coded_by="NM_001179257.1:1..732" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:18194531]" /note="hypothetical protein; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis" /db_xref="GeneID:856528" /db_xref="SGD:S000001169" ORIGIN 1 marnrttskk nvqskrlidr vvpmdkikkv gvakkktveh tkegfsvvng klvssndvgv 61 llreaqgaid krtnvsqrnr kkgiknnrph kdinsspdwg nahrgtdwqs ekangmnrak 121 nsrnfttnik lqrqhfgeei qggsqlvist nsdasdkllm lfnltlgvnq enlknvleni 181 sqvqiaqirv rdlpsgsata kvrlaypttq slekvrklfh galvdgrriq vviasdessh 241 lsy // LOCUS NP_011996 216 aa linear PLN 30-JUN-2025 DEFINITION uracil phosphoribosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_011996 VERSION NP_011996.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179258.1 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 216) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06821. On Oct 2, 2003 this sequence version replaced NP_011996.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..216 /product="uracil phosphoribosyltransferase" /EC_number="2.4.2.9" /calculated_mol_wt="24463" Region 14..214 /region_name="UPRTase" /note="Uracil phosphoribosyltransferase; pfam14681" /db_xref="CDD:434124" Site order(84,86,137..139,141..145,171) /site_type="active" /db_xref="CDD:206754" CDS 1..216 /gene="FUR1" /locus_tag="YHR128W" /coded_by="NM_001179258.1:1..651" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:2189783]" /experiment="EXISTENCE:direct assay:GO:0004845 uracil phosphoribosyltransferase activity [PMID:2189783]" /experiment="EXISTENCE:direct assay:GO:0008655 pyrimidine-containing compound salvage [PMID:2189783]" /note="Uracil phosphoribosyltransferase; synthesizes UMP from uracil; involved in the pyrimidine salvage pathway" /db_xref="GeneID:856529" /db_xref="SGD:S000001170" ORIGIN 1 mssepfknvy llpqtnqllg lytiirnknt trpdfifysd riirllveeg lnhlpvqkqi 61 vetdtnenfe gvsfmgkicg vsivragesm eqglrdccrs vrigkiliqr deetalpklf 121 yeklpedise ryvflldpml atggsaimat evlikrgvkp eriyflnlic skegiekyha 181 afpevrivtg aldrgldenk ylvpglgdfg dryycv // LOCUS NP_011997 384 aa linear PLN 30-JUN-2025 DEFINITION actin-related protein 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_011997 VERSION NP_011997.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179259.1 REFERENCE 1 (residues 1 to 384) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 384) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 384) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 384) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06822. Method: conceptual translation. FEATURES Location/Qualifiers source 1..384 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..384 /product="actin-related protein 1" /calculated_mol_wt="42865" Region 12..379 /region_name="ASKHA_NBD_Arp1" /note="nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; cd10216" /db_xref="CDD:466820" CDS 1..384 /gene="ARP1" /locus_tag="YHR129C" /gene_synonym="ACT5" /coded_by="NM_001179259.1:1..1155" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:9658168]" /experiment="EXISTENCE:direct assay:GO:0005869 dynactin complex [PMID:9658168]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:11285282]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:8069915]" /experiment="EXISTENCE:mutant phenotype:GO:0007097 nuclear migration [PMID:8069915]" /note="Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; forms actin-like short filament composed of 9 or 10 Arp1p monomers; putative ortholog of mammalian centractin" /db_xref="GeneID:856530" /db_xref="SGD:S000001171" ORIGIN 1 mdqlsdsyal ynqpvvidng sgiikagfsg eerpkaleyc lvgntkydkv mleglqgdtf 61 ignnaqklrg llklrypikh gvvedwdsme liwsyvlnev lqlqnigehp lliteapmnp 121 lknreqmaqv lfetfdvsal yvsnpavlsl yasgrttgcv vdcgegycst vpiydgfalp 181 asmmrmdigg aditeqlqfq lrksagvslf sssereivrt mkekvcylak nikkeeekyl 241 qgtqdlistf klpdgrciev gndryrapei lfspqiiglg ydglsdmcmq siwkvdldlr 301 kpllssiils ggtttlkgfg drmlwdleal tkgtskikii apserkyttw iggsiltgls 361 tfqrlwtkks dwledstrvy snlm // LOCUS NP_001335741 111 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR130C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335741 VERSION NP_001335741.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348825.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 111) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80261. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..111 /product="uncharacterized protein" /calculated_mol_wt="13266" CDS 1..111 /locus_tag="YHR130C" /coded_by="NM_001348825.1:1..336" /note="hypothetical protein; conserved among S. cerevisiae strains; YHR130C is not an essential gene" /db_xref="GeneID:856531" /db_xref="SGD:S000001172" ORIGIN 1 mtksiyiiig ymlhdeeffy fffisfytlw ivffllhlsf fstlsfgifh dfdtdvyikv 61 gnyilhflel sknsnllkns semlkhfrla slmymyvytq micpsllgir n // LOCUS NP_011999 850 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR131C [Saccharomyces cerevisiae S288C]. ACCESSION NP_011999 VERSION NP_011999.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179261.1 REFERENCE 1 (residues 1 to 850) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 850) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 850) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 850) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 850) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 850) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 850) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06823. On Aug 2, 2004 this sequence version replaced NP_011999.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..850 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..850 /product="uncharacterized protein" /calculated_mol_wt="95969" CDS 1..850 /locus_tag="YHR131C" /coded_by="NM_001179261.1:1..2553" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study; YHR131C has a paralog, MPF1, that arose from the whole genome duplication" /db_xref="GeneID:856532" /db_xref="SGD:S000001173" ORIGIN 1 malpiegkls mannrierlk spsssstcsm devlitssnn sssicletmr qlpregvsgq 61 iniiketaas ssshaalfik qdlyehidpl payppsydlv npnkevrfpi fgdtapcpks 121 slpplyapav yeltlislkl erlspyeiss nrswrnfiie instqlnfyh idesltkhir 181 nyssgetkse kedrihsdlv hrsdqsqhlh hrlftlptrs asefkkadqe risyrvkrdr 241 sryltdealy ksftlqnarf giptdytkks fvlrmscese qfllrfshid dmidwsmyls 301 igisvsldle vreypdyriv prrrrrrrrr rrrrrhthrs essmgsfsqr firsnsrpdl 361 iqrystgsst nnnttirers ntftaglldh yctglsktpt ealissaasg essdnstlgs 421 trslsgcsas rsiasrslkf kiknffrpkn ssrteklhrl rsnssnlnsv ieteeddehh 481 essggdhpep gvpvnttikv erpmhrnrai smpqrqslrr aiseevvpik fpnstvgesv 541 hspspiehls vdgceimlqs qnavmkeelr svasnlvane rdeasirpkp qsssiylsgl 601 apngesatdl sqssrslclt nrdaeindde satetdeden dgetdeyagd dtnddtddsn 661 igyaygsesd ysclieerir nrrrasstls cfsnipygtd dikwkpaike isrrrylrds 721 lkcikpflds ndclgkviyi pvsgptfets nkihfsnrqs lqkqknhflk gfivgptali 781 elncknknai vgttkdaedh geddgdgddg eddddddddd ddddddeddd dddddddddd 841 dddddgqita // LOCUS NP_012000 430 aa linear PLN 30-JUN-2025 DEFINITION putative metallocarboxypeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012000 VERSION NP_012000.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179262.1 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 430) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06824. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..430 /product="putative metallocarboxypeptidase" /calculated_mol_wt="49698" Region 121..425 /region_name="M14_CP_A-B_like" /note="Peptidase M14 carboxypeptidase subfamily A/B-like; cd03860" /db_xref="CDD:349433" Site order(182,185,240,257..258,310,369,371,391) /site_type="active" /db_xref="CDD:349433" CDS 1..430 /gene="ECM14" /locus_tag="YHR132C" /coded_by="NM_001179262.1:1..1293" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762|PMID:14562095]" /note="Putative pseudopeptidase; conserved fungal protein and member of the M14 family of metallocarboxypeptidases but contains substitutions in active site residues important for catalysis and lacks activity with standard substrates; contains a cleavable pro domain; required for normal cell wall assembly in some strains" /db_xref="GeneID:856533" /db_xref="SGD:S000001174" ORIGIN 1 mlhmnslwgc flfvllavtg avqglqedys eyavyrftsd nystlvrdvi apltddydvw 61 trsnnfidik lpkeigeqin dgqviidnmn eliqntlpts qmmareqavf endydfffne 121 yrdldtiymw ldllersfps lvavehlgrt fegrelkalh isgnkpesnp ekktivitgg 181 iharewisvs tvcwalyqll nrygsskket kylddldflv ipvfnpdgya ytwshdrlwr 241 knrqrthvpq clgididhsf gfqwekahth acseeysget pfeaweasaw ykyinetkgd 301 ykiygyidmh sysqeilypy ayscdalprd lenllelsyg lskairsksg rnydvisack 361 drgsdifpgl gagsaldfmy hhrahwafql klrdtgnhgf llppenikpv gketyaalky 421 fcdflldpei // LOCUS NP_036194 131 aa linear PLN 30-JUN-2025 DEFINITION phosphatase regulator [Saccharomyces cerevisiae S288C]. ACCESSION NP_036194 VERSION NP_036194.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184441.1 REFERENCE 1 (residues 1 to 131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 131) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06825. Method: conceptual translation. FEATURES Location/Qualifiers source 1..131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..131 /product="phosphatase regulator" /calculated_mol_wt="14264" Region 26..105 /region_name="Endosulfine" /note="cAMP-regulated phosphoprotein/endosulfine conserved region; pfam04667" /db_xref="CDD:398375" CDS 1..131 /gene="IGO2" /locus_tag="YHR132W-A" /coded_by="NM_001184441.1:1..396" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:28100785]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:23861665]" /experiment="EXISTENCE:genetic interaction:GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:20471941]" /experiment="EXISTENCE:genetic interaction:GO:1901992 positive regulation of mitotic cell cycle phase transition [PMID:23861665]" /experiment="EXISTENCE:genetic interaction:GO:1903452 positive regulation of G1 to G0 transition [PMID:23273919|PMID:20471941]" /note="Protein required for initiation of the G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylation (S64) by Rim15p increases interaction with and inhibition of PP2A-Cdc55 for timely mitotic progression; can also activate PP2A-Cdc55 complexes and influence Cdc55p localization along with Igo1p; GFP protein localizes to the cytoplasm and nucleus; IGO2 has a paralog, IGO1, that arose from the whole genome duplication" /db_xref="GeneID:856534" /db_xref="SGD:S000007496" ORIGIN 1 msedlsptss rvdlsnphgf tkegvdlskl spqelklykm ygklpskkdl lrhkmqdrqy 61 fdsgdyalkk agviksddvi vnnssnnlpv tnpsglresi irrrmssssg gdsisrqgsi 121 ssgppprspn k // LOCUS NP_012001 291 aa linear PLN 30-JUN-2025 DEFINITION Nsg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012001 VERSION NP_012001.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179263.1 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 291) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06826. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..291 /product="Nsg1p" /calculated_mol_wt="32083" Region 104..290 /region_name="INSIG" /note="Insulin-induced protein (INSIG); pfam07281" /db_xref="CDD:462131" CDS 1..291 /gene="NSG1" /locus_tag="YHR133C" /coded_by="NM_001179263.1:1..876" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16270032|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0016126 sterol biosynthetic process [PMID:16270032]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:16270032]" /experiment="EXISTENCE:physical interaction:GO:0016126 sterol biosynthetic process [PMID:16270032]" /experiment="EXISTENCE:physical interaction:GO:0051082 unfolded protein binding [PMID:16270032]" /note="Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication" /db_xref="GeneID:856535" /db_xref="SGD:S000001175" ORIGIN 1 mgkkksknql ntggvpngvh ntkkeaalpp lgnklgsasf taintltkpa lfsfydddit 61 knegnvydka llsnasqlem vppsatarhe rslyakiint iaaffilfia gilfpmisec 121 lfdndqlakg divsflkhgi eiknkivaep dmvpdwavfg tegvifgsiv pfidsfvryq 181 hqpktrssvy kntlgsfirc antllglifg irklewsssl qaagawslln ivlwlffdgt 241 ltvffpglvi galsaftcsq cfsqlslaly fidfyffgfl mfsklgrylf n // LOCUS NP_012002 269 aa linear PLN 30-JUN-2025 DEFINITION metalloendopeptidase WSS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012002 VERSION NP_012002.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179264.1 REFERENCE 1 (residues 1 to 269) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 269) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 269) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 269) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06827. Method: conceptual translation. FEATURES Location/Qualifiers source 1..269 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..269 /product="metalloendopeptidase WSS1" /calculated_mol_wt="30496" Region 27..221 /region_name="WLM" /note="WLM domain; pfam08325" /db_xref="CDD:311984" CDS 1..269 /gene="WSS1" /locus_tag="YHR134W" /coded_by="NM_001179264.1:1..810" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26349035]" /experiment="EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:24998930]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:18336552]" /experiment="EXISTENCE:direct assay:GO:0008237 metallopeptidase activity [PMID:26349035]" /experiment="EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:26349035]" /experiment="EXISTENCE:direct assay:GO:0019985 translesion synthesis [PMID:24998930]" /experiment="EXISTENCE:direct assay:GO:0032183 SUMO binding [PMID:26349035]" /experiment="EXISTENCE:direct assay:GO:0061665 SUMO ligase activity [PMID:26349035]" /experiment="EXISTENCE:direct assay:GO:1990466 protein autosumoylation [PMID:26349035]" /experiment="EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:11606525]" /experiment="EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:24998930]" /experiment="EXISTENCE:mutant phenotype:GO:0019985 translesion synthesis [PMID:24998930]" /experiment="EXISTENCE:mutant phenotype:GO:0036205 histone catabolic process [PMID:32130911]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="SUMO-ligase and SUMO-targeted metalloprotease; involved in DNA repair; removes DNA-protein crosslinks at stalled replication forks during replication of damaged DNA; clears chromatin-bound sumoylated proteins; localizes to single spot on nuclear periphery of mother cells but not daughters; exhibits vacuolar localization upon genotoxic stress; activated by DNA binding; member of minigluzincins protease family with mammalian DVC1/Spartan" /db_xref="GeneID:856536" /db_xref="SGD:S000001176" ORIGIN 1 mktegiksps akyhdmagsq riphknphiq kvavlqskpn kedalnlike iahkvsylmk 61 enhfkvtnlv efyprdqrll gmnvnhgski mlrlrcstde fqflpmecim gtmlhelthn 121 lfgphdkkfy nkldeligrq wvieqrglyd tflgngqrlg granlrsnry pmtgistntg 181 ivrkrgkgvk lgslhpegis sidrgnspre laafaaerry rddrwcgetk nnkdqiisdn 241 issslevvil ddddevlpgd tlievidlt // LOCUS NP_012003 538 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase YCK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012003 VERSION NP_012003.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179265.1 REFERENCE 1 (residues 1 to 538) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 538) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 538) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 538) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06828. Method: conceptual translation. FEATURES Location/Qualifiers source 1..538 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..538 /product="serine/threonine protein kinase YCK1" /EC_number="2.7.11.1" /calculated_mol_wt="61584" Region 68..344 /region_name="STKc_CK1_fungal" /note="Catalytic domain of the Serine/Threonine protein kinase, Fungal Casein Kinase 1 homolog 1; cd14127" /db_xref="CDD:271029" Site order(75..81,83,96,98,142..146,148,150,188,190,192..193, 195,211,214,237..240) /site_type="active" /db_xref="CDD:271029" Site order(75..81,83,96,98,142..146,190,192..193,195,210..211) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271029" Site order(79,148,150,188,190,192,214,237..240) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271029" Site 210..240 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271029" CDS 1..538 /gene="YCK1" /locus_tag="YHR135C" /gene_synonym="CKI2" /coded_by="NM_001179265.1:1..1617" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8474447]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:8034689|PMID:1627830]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0010255 glucose mediated signaling pathway [PMID:27630263]" /experiment="EXISTENCE:mutant phenotype:GO:0000902 cell morphogenesis [PMID:10198058]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:10198058]" /experiment="EXISTENCE:mutant phenotype:GO:0009749 response to glucose [PMID:14755054]" /note="Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK1 has a paralog, YCK2, that arose from the whole genome duplication" /db_xref="GeneID:856537" /db_xref="SGD:S000001177" ORIGIN 1 msmpiasttl avnnltning nanfnvqank qlhhqavdsp arssmtatta ansnsnssrd 61 dstivglhyk igkkigegsf gvlfegtnmi ngvpvaikfe prkteapqlr deyktykiln 121 gtpnipyayy fgqeglhnil vidllgpsle dlfdwcgrkf svktvvqvav qmitliedlh 181 ahdliyrdik pdnfligrpg qpdannihli dfgmakqyrd pktkqhipyr ekkslsgtar 241 ymsinthlgr eqsrrddmea lghvffyflr ghlpwqglka pnnkqkyeki gekkrstnvy 301 dlaqglpvqf gryleivrsl sfeecpdyeg yrklllsvld dlgetadgqy dwmklndgrg 361 wdlninkkpn lhgyghpnpp neksrkhrnk qlqmqqlqmq qlqqqqqqqq yaqkteadmr 421 nsqykpkldp tsyeayqhqt qqkylqeqqk rqqqqklqeq qlqeqqlqqq qqqqqqlrat 481 gqppsqpqaq tqsqqfgary qpqqqpsaal rtpeqhpndd nsslaashkg ffqklgcc // LOCUS NP_012004 148 aa linear PLN 30-JUN-2025 DEFINITION Spl2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012004 VERSION NP_012004.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179266.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 148) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06829. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..148 /product="Spl2p" /calculated_mol_wt="16905" CDS 1..148 /gene="SPL2" /locus_tag="YHR136C" /coded_by="NM_001179266.1:1..447" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:21143198]" /note="Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation by targeting Pho87p to the vacuole; upstream region harbors putative hypoxia response element (HRE) cluster; overproduction suppresses a plc1 null mutation; promoter shows an increase in Snf2p occupancy after heat shock; GFP-fusion protein localizes to the cytoplasm" /db_xref="GeneID:856538" /db_xref="SGD:S000001178" ORIGIN 1 mgtytpliyn iynvhiwvft esqgqigqms prgkmetavs qgqhkqlkdg hqhkgrklse 61 eiasllrlke crrlnpasyy tprrtsqsqs lsgstfkeyn eyinekdssr aqrqnaaavl 121 sklahdfwen dcvidedife dssdeeqs // LOCUS NP_012005 513 aa linear PLN 30-JUN-2025 DEFINITION aromatic-amino-acid:2-oxoglutarate transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012005 VERSION NP_012005.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179267.1 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 513) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06830. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..513 /product="aromatic-amino-acid:2-oxoglutarate transaminase" /EC_number="2.6.1.7" /EC_number="2.6.1.57" /calculated_mol_wt="58397" Region <41..507 /region_name="ARO8" /note="DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; COG1167" /db_xref="CDD:440781" CDS 1..513 /gene="ARO9" /locus_tag="YHR137W" /coded_by="NM_001179267.1:1..1542" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006571 tyrosine biosynthetic process [PMID:9491082]" /experiment="EXISTENCE:genetic interaction:GO:0009094 L-phenylalanine biosynthetic process [PMID:9491082]" /experiment="EXISTENCE:mutant phenotype:GO:0008793 aromatic-amino-acid transaminase activity [PMID:9491082]" /experiment="EXISTENCE:mutant phenotype:GO:0009072 aromatic amino acid metabolic process [PMID:9491083]" /note="Aromatic aminotransferase II; involved in tyrosine, phenylalanine, and methionine metabolism; involved with Aro8p in production of kynurenic acid to detoxify excess tryptophan" /db_xref="GeneID:856539" /db_xref="SGD:S000001179" ORIGIN 1 mtagsappvd ytslkknfqp flsrrvenrs lksfwdasdi sddvielagg mpnerffpie 61 smdlkiskvp fndnpkwhns fttahldlgs pselpiarsf qyaetkglpp llhfvkdfvs 121 rinrpafsde tesnwdvils ggsndsmfkv feticdestt vmieeftftp amsnveatga 181 kvipikmnlt fdresqgidv eyltqlldnw stgpykdlnk prvlytiatg qnptgmsvpq 241 wkrekiyqla qrhdflived dpygylyfps ynpqeplenp yhssdltter ylndflmksf 301 ltldtdarvi rletfskifa pglrlsfiva nkfllqkild ladittraps gtsqaivyst 361 ikamaesnls sslsmkeamf egwirwimqi askynhrknl tlkalyetes yqagqftvme 421 psagmfiiik inwgnfdrpd dlpqqmdild kfllkngvkv vlgykmavcp nyskqnsdfl 481 rltiayardd dqlieaskri gsgikeffdn yks // LOCUS NP_012006 114 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR138C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012006 VERSION NP_012006.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179268.1 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 114) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06831. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..114 /product="uncharacterized protein" /calculated_mol_wt="12621" CDS 1..114 /locus_tag="YHR138C" /coded_by="NM_001179268.1:1..345" /experiment="EXISTENCE:mutant phenotype:GO:0004866 endopeptidase inhibitor activity [PMID:9657146]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:9657146]" /note="hypothetical protein; similar to Pbi2p; double null mutant lacking Pbi2p and Yhr138cp exhibits highly fragmented vacuoles; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856540" /db_xref="SGD:S000001180" ORIGIN 1 mkasylvlif isifsmaqas slssyivtfp ktdnmatdqn siiedvkkyv vdiggkithe 61 yslikgftvd lpdsdqildg lkerlsyies eygakcnlek dsevhalnrd hlva // LOCUS NP_012007 326 aa linear PLN 30-JUN-2025 DEFINITION Sps100p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012007 VERSION NP_012007.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179269.1 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 326) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06832. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..326 /product="Sps100p" /calculated_mol_wt="34095" Region 33..318 /region_name="L-asparaginase_like" /note="Bacterial L-asparaginases and related enzymes; cl00216" /db_xref="CDD:469665" CDS 1..326 /gene="SPS100" /locus_tag="YHR139C" /coded_by="NM_001179269.1:1..981" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:3280971]" /note="Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin; SPS100 has a paralog, YGP1, that arose from the whole genome duplication" /db_xref="GeneID:856541" /db_xref="SGD:S000001181" ORIGIN 1 mkftsvlaff latltasatp lykrqnvtsg ggtvpviitg gpavsgsqsn vttttlfnst 61 stlnitqlyq iatqvnqtlq sesssgiiiv tnwrsietls ffcsivfnts ktivitenfl 121 wgvpilsssd aegrgtlvag rdkvvysgvf ppytvpvgvl sgqknvqwff daceptlias 181 nstirtqysn ftsaqissna ssgtntssss ssplvpiiye egysqsliqs lsssiqglvv 241 vssgtshnst vaswtsvdfp vvyasdgssg hdgsgigfis ntsipqgais agylspiqaq 301 tllsiaihnq vtssselqqi fpvsqq // LOCUS NP_001335742 103 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR139C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335742 VERSION NP_001335742.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348830.1 REFERENCE 1 (residues 1 to 103) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 103) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 103) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 103) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80262. Method: conceptual translation. FEATURES Location/Qualifiers source 1..103 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..103 /product="uncharacterized protein" /calculated_mol_wt="11771" CDS 1..103 /locus_tag="YHR139C-A" /coded_by="NM_001348830.1:1..312" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:856542" /db_xref="SGD:S000003533" ORIGIN 1 mrsadfsnpr ilsnlmskse kekraiiifn crlnkglyvt sacvsrsvfr cckqeplief 61 vspkmiafvq idgryltkml tcdihvrkea kegrgyqqih kls // LOCUS NP_012009 239 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR140W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012009 VERSION NP_012009.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179270.1 REFERENCE 1 (residues 1 to 239) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 239) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 239) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 239) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06833. Method: conceptual translation. FEATURES Location/Qualifiers source 1..239 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..239 /product="uncharacterized protein" /calculated_mol_wt="27015" Region <83..220 /region_name="Far-17a_AIG1" /note="FAR-17a/AIG1-like protein; pfam04750" /db_xref="CDD:428104" CDS 1..239 /locus_tag="YHR140W" /coded_by="NM_001179270.1:1..720" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:31945465|PMID:22842922]" /note="Endoplasmic reticulum protein; may contribute to maintenance of ER and nuclear morphology; null mutant shows discontinuity in nuclear envelope, clustering of nuclear pores, and lacks cortical ER" /db_xref="GeneID:856543" /db_xref="SGD:S000001182" ORIGIN 1 mmsclvptrf tltlntacll tstwgfvrat svvlppslsk aghkqfltii siiatiinna 61 vnisnyyiqr nnkmnletkk ksdfisrhvt lpvslvlesi vatvywplrl ffvnlimhgv 121 estaktpfpm tvdmaihlyp ilylladhyl sgsgtkfkls nkhawlivts lafsyfqyla 181 flidagqgqa ypypfldvne pyksiifvvv atitwayyvf yqkfppkyik ksakkgdkn // LOCUS NP_012010 106 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL42 RPL42B [Saccharomyces cerevisiae S288C]. ACCESSION NP_012010 VERSION NP_012010.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179271.1 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 106) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06834. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..106 /product="60S ribosomal protein eL42 RPL42B" /calculated_mol_wt="12080" Region 1..86 /region_name="PTZ00157" /note="60S ribosomal protein L36a; Provisional" /db_xref="CDD:240296" CDS 1..106 /gene="RPL42B" /locus_tag="YHR141C" /gene_synonym="MAK18" /coded_by="NM_001179271.1:1..321" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication" /db_xref="GeneID:856544" /db_xref="SGD:S000001183" ORIGIN 1 mvnvpktrkt yckgktcrkh tqhkvtqyka gkaslfaqgk rrydrkqsgf ggqtkpvfhk 61 kakttkkvvl rlecvkcktr aqltlkrckh felggekkqk gqalqf // LOCUS NP_012011 316 aa linear PLN 30-JUN-2025 DEFINITION Chs7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012011 VERSION NP_012011.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179272.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 316) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06835. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..316 /product="Chs7p" /calculated_mol_wt="34767" Region 2..299 /region_name="Chs7" /note="Chitin synthase export chaperone; pfam12271" /db_xref="CDD:432442" CDS 1..316 /gene="CHS7" /locus_tag="YHR142W" /coded_by="NM_001179272.1:1..951" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10366589]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:29405545]" /experiment="EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10366589]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:10366589]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15623581]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:15623581]" /note="hypothetical protein; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress" /db_xref="GeneID:856545" /db_xref="SGD:S000001184" ORIGIN 1 mafsdfaaic sktplplcsv ikskthlils nstiihdfdp lnlnvgvlpr cyarsidlan 61 tvifdvgnaf inigalgvil iilynirqky taigrseyly ffqltlllii ftlvvdcgvs 121 ppgsgsypyf vaiqiglaga ccwalliigf lgfnlwedgt tksmllvrgt smlgfianfl 181 asiltfkawi tdhkvatmna sgmivvvyii naiflfvfvi cqllvsllvv rnlwvtgaif 241 lglfffvagq vlvyafstqi cegfkhyldg lffgsicnvf tlmmvyktwd mttdddlefg 301 vsvskdgdvv ydngfm // LOCUS NP_012012 325 aa linear PLN 30-JUN-2025 DEFINITION Dse2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012012 VERSION NP_012012.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179274.1 REFERENCE 1 (residues 1 to 325) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 325) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 325) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 325) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06836. Method: conceptual translation. FEATURES Location/Qualifiers source 1..325 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..325 /product="Dse2p" /calculated_mol_wt="33286" CDS 1..325 /gene="DSE2" /locus_tag="YHR143W" /coded_by="NM_001179274.1:1..978" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:27229769]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11309124]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:11309124]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:11309124]" /note="Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother; localizes in birth scars; expression is repressed by cAMP" /db_xref="GeneID:856546" /db_xref="SGD:S000001186" ORIGIN 1 mkfnfstifn ilfflftlie ansngetvkl itsdgivysy avytktlapa rvvvktisyt 61 ttrvypitla nsvvssttek itevstvsas eqvsatqtns lvststvsti sptissgsst 121 sssstydies sqsiessgts sataepsass gfrltsssaf vsstapfssq lssssssets 181 sssfstssss aplsltssss ssssfatiit lapsssksgn sqltlassss tsavessqtg 241 stiarttstl vpsssvdtts rattsmples sstqsisvss sdgtcyvfyd dddyystvyl 301 tnpsqsvdaa ttitstntiy atvti // LOCUS NP_012013 70 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase core subunit RPC10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012013 VERSION NP_012013.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179273.1 REFERENCE 1 (residues 1 to 70) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 70) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 70) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 70) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06837. Method: conceptual translation. FEATURES Location/Qualifiers source 1..70 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..70 /product="DNA-directed RNA polymerase core subunit RPC10" /calculated_mol_wt="7585" Region 27..70 /region_name="RPOLCX" /note="RNA polymerase subunit CX; smart00659" /db_xref="CDD:128906" CDS 1..70 /gene="RPC10" /locus_tag="YHR143W-A" /gene_synonym="RPB12" /coded_by="NM_001179273.1:1..213" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:9837969|PMID:3905793|PMID:8288647]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1748681|PMID:1331084]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:1748681|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:9837969|PMID:1748681]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:1748681]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:genetic interaction:GO:0006383 transcription by RNA polymerase III [PMID:10531351]" /experiment="EXISTENCE:mutant phenotype:GO:0006360 transcription by RNA polymerase I [PMID:10531351]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:10531351]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:10531351]" /note="RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress; localizes to the peroxisome in a Pex5p-dependent manner" /db_xref="GeneID:856547" /db_xref="SGD:S000001185" ORIGIN 1 msregfqipt nldaaaagts qartatlkyi caecssklsl srtdavrckd cghrillkar 61 tkrlvqfear // LOCUS NP_012014 312 aa linear PLN 30-JUN-2025 DEFINITION deoxycytidine monophosphate deaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012014 VERSION NP_012014.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179275.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 312) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06838. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..312 /product="deoxycytidine monophosphate deaminase" /EC_number="3.5.4.12" /calculated_mol_wt="35515" Region 159..307 /region_name="ComEB" /note="Deoxycytidylate deaminase [Nucleotide transport and metabolism]; COG2131" /db_xref="CDD:441734" CDS 1..312 /gene="DCD1" /locus_tag="YHR144C" /coded_by="NM_001179275.1:1..939" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004132 dCMP deaminase activity [PMID:3023902]" /experiment="EXISTENCE:mutant phenotype:GO:0006226 dUMP biosynthetic process [PMID:6373725]" /experiment="EXISTENCE:mutant phenotype:GO:0006231 dTMP biosynthetic process [PMID:6373725]" /note="Deoxycytidine monophosphate (dCMP) deaminase; involved in dUMP and dTMP biosynthesis; expression is NOT cell cycle regulated" /db_xref="GeneID:856548" /db_xref="SGD:S000001187" ORIGIN 1 mligvsgtkf cgcedvinml vdhfhfelln hldnpeeild yatknytkns vifleklsll 61 eklekrpffv hlsidapvtt rvalyrkttq aeslsleqii qaidqhdfqp egiklreksh 121 lrfkivnedr rgrrqslinn ittqlkildd kekqmaplmr pswdsyfmkl atlaasrsnc 181 mkrrvgcviv recrviatgy ngtprhltnc fnggcprcnd gdsrnlhtcl clhaeenall 241 eagrdrvgqn atlycdtcpc ltcsvkivqt gisevvysqs yrmdeesfkv lknagitvrq 301 fsfteepriv mi // LOCUS NP_012016 465 aa linear PLN 30-JUN-2025 DEFINITION Crp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012016 VERSION NP_012016.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179277.1 REFERENCE 1 (residues 1 to 465) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 465) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 465) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 465) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06839. Method: conceptual translation. FEATURES Location/Qualifiers source 1..465 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..465 /product="Crp1p" /calculated_mol_wt="50985" Region 8..90 /region_name="E_set_AMPKbeta_like_N" /note="N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; cd02859" /db_xref="CDD:199889" Site order(29,61,68,79..81,83,85) /site_type="other" /note="glycogen binding site [chemical binding]" /db_xref="CDD:199889" CDS 1..465 /gene="CRP1" /locus_tag="YHR146W" /coded_by="NM_001179277.1:1..1398" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:12419258]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12419258]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:38832010]" /note="Protein that binds to cruciform DNA structures; CRP1 has a paralog, MDG1, that arose from the whole genome duplication" /db_xref="GeneID:856551" /db_xref="SGD:S000001189" ORIGIN 1 msselmfnyt fswpagpkdv iltgtfddwr gtlplvktak gnfeitmpvk lankddtfqf 61 kfivdgvwcv sdsykkehvs egiennflqi tdlvetqeva gasripeagg llcgkpprsa 121 gppstsnrkk nkrnnkkrrs klkkkstknn kksneslddn eeedgvtgtt tedvtgtsre 181 etplaeptnv skeapgnfhi lpidqsadtt qsngiiggpg pvlvpnpgei kefteirdvd 241 arelnerlnk keevpepvag pivessvtek spalpqaddp ivetkevahn vqeltpqvea 301 vtplinepep lptpeaqisi pesskvepve gslqsklvek restegvldg skkvenkakk 361 deevftldpi vnkapklplt deqtaegrks pavseekekk kkqekgskev krsetskekk 421 psakevkkqt vkapkkqtas plsssteepk kkktgffgkl kklfk // LOCUS NP_012017 214 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL6m MRPL6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012017 VERSION NP_012017.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179278.1 REFERENCE 1 (residues 1 to 214) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 214) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 214) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 214) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06840. Method: conceptual translation. FEATURES Location/Qualifiers source 1..214 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..214 /product="mitochondrial 54S ribosomal protein uL6m MRPL6" /calculated_mol_wt="23758" Region 17..212 /region_name="L6_bact" /note="ribosomal protein L6, bacterial type; TIGR03654" /db_xref="CDD:274703" CDS 1..214 /gene="MRPL6" /locus_tag="YHR147C" /gene_synonym="uL6m" /coded_by="NM_001179278.1:1..645" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:856552" /db_xref="SGD:S000001190" ORIGIN 1 msfiqrrlls qtlflrsqvg slplyispev qvsinalsmp riirkgrtsm nisqnitvkg 61 pkgelsvevp dflhldkdek hgkinvtvqn sedkhqrsmw gtvrslinnh iigvteghla 121 vlrfvgtgyr aqlendgkfv nvkvgasikq gldvpegivv ktpaptslii egcnkqqvll 181 faaklrkfhp pepykgkgiy vndetiklkd kkik // LOCUS NP_012018 183 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-binding rRNA-processing protein IMP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012018 VERSION NP_012018.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179279.1 REFERENCE 1 (residues 1 to 183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 183) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06841. Method: conceptual translation. FEATURES Location/Qualifiers source 1..183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..183 /product="snoRNA-binding rRNA-processing protein IMP3" /calculated_mol_wt="21754" Region 4..108 /region_name="Ribosomal_S4" /note="Ribosomal protein S4/S9 N-terminal domain; pfam00163" /db_xref="CDD:459696" Region <54..164 /region_name="PLN00189" /note="40S ribosomal protein S9; Provisional" /db_xref="CDD:177783" CDS 1..183 /gene="IMP3" /locus_tag="YHR148W" /coded_by="NM_001179279.1:1..552" /experiment="EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:23980203]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:23980203|PMID:15489263]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034457 Mpp10 complex [PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0042274 ribosomal small subunit biogenesis [PMID:23980203]" /experiment="EXISTENCE:direct assay:GO:0140691 RNA folding chaperone [PMID:23980203|PMID:15489263]" /experiment="EXISTENCE:mutant phenotype:GO:0032040 small-subunit processome [PMID:12242301]" /note="Subunit of the MPP10 chaperone complex and the small subunit (SSU) processome; contains U3 snoRNA binding and RNA chaperone activities; SSU processome is required for pre-18S rRNA processing; essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA" /db_xref="GeneID:856553" /db_xref="SGD:S000001191" ORIGIN 1 mvrklkhheq kllkkvdfle wkqdqghrdt qvmrtyhiqn redyhkynri cgdirrlank 61 lsllpptdpf rrkheqllld klyamgvltt kskisdlenk vtvsaicrrr lpvimhrlkm 121 aetiqdavkf ieqghvrvgp nlindpaylv trnmedyvtw vdnskikktl lryrnqiddf 181 dfs // LOCUS NP_012019 734 aa linear PLN 30-JUN-2025 DEFINITION Skg6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012019 VERSION NP_012019.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179280.1 REFERENCE 1 (residues 1 to 734) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 734) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 734) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 734) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 734) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 734) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 734) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06842. Method: conceptual translation. FEATURES Location/Qualifiers source 1..734 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..734 /product="Skg6p" /calculated_mol_wt="81718" Region 53..731 /region_name="SKG6" /note="SKG6 family; pfam08693" /db_xref="CDD:462564" CDS 1..734 /gene="SKG6" /locus_tag="YHR149C" /coded_by="NM_001179280.1:1..2205" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:16314687]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11489916|PMID:16314687]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11489916]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:16314687]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:16314687]" /experiment="EXISTENCE:genetic interaction:GO:1902413 negative regulation of mitotic cytokinesis [PMID:16816427]" /experiment="EXISTENCE:mutant phenotype:GO:1902413 negative regulation of mitotic cytokinesis [PMID:16816427]" /note="Integral membrane protein; localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p; SKG6 has a paralog, TOS2, that arose from the whole genome duplication" /db_xref="GeneID:856554" /db_xref="SGD:S000001192" ORIGIN 1 myhthmhesl isvtstvsvs dasyayarlt rrddsdssss sasstknsks aectgskqqc 61 qlptdsshst svtvgvavav pvgviiivla vilcivyrrs kkeaeedndp dfegdseflp 121 tmkdyspgin hlyssdsqqd fmektlqqpp sdpfvgsmhs skynvrsatp paigrswyvd 181 pfqlpqesnd snslrdfamr vqedglggyk vaaesrnasq tslhpdnfsn ctpirassrf 241 qesesfrshg spihnnqlsr gsategankq ftfpnednds ssvseeaevl nesnesasnd 301 afefeldnss ekthernlrf gkdddnyelq direaehmnd rsssksqddd yyvsllspne 361 eedikrmksi yqvyldrakt mkkeedkadn andisqeenr vdnivqnplp sikinnndni 421 dnnevpeakh lvkealplnn tnlaeygpem aqsqkqypvq dtltvndtea apsnriassi 481 yseaiqplny qdqyqqqeqs pvynghtqyp gngysgnpqq qgytaqfvqn pqwygvptpq 541 qqqhnhpqtl etigelptpa ylaqsasshs ltsfkrpnkq qllqlqtarl ngtalnpvdh 601 pemfysptnd ayyapqqqgq ymkfnengav pspyqlrqsv vmtnpsdlta kpsykpagsf 661 rsvsatnsrn nslttqnniy lqqqqqqlyn srvsgileet dvvqppsvgg ilphsgsqdd 721 lrkqlgsshn ytvn // LOCUS NP_012020 579 aa linear PLN 30-JUN-2025 DEFINITION Pex28p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012020 VERSION NP_012020.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179281.1 REFERENCE 1 (residues 1 to 579) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 579) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 579) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 579) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06843. Method: conceptual translation. FEATURES Location/Qualifiers source 1..579 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..579 /product="Pex28p" /calculated_mol_wt="66017" Region 201..569 /region_name="Pex24p" /note="Integral peroxisomal membrane peroxin; pfam06398" /db_xref="CDD:399414" CDS 1..579 /gene="PEX28" /locus_tag="YHR150W" /coded_by="NM_001179281.1:1..1740" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:12707309]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0007031 peroxisome organization [PMID:12707309]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:12707309]" /note="Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p" /db_xref="GeneID:856555" /db_xref="SGD:S000001193" ORIGIN 1 msetsssrrs askdavksyf agkynkvlds ileaeaaisk sptvaedlsg ssssgnsems 61 hpsltassat sqgiskkell qqiagslfst sierlktahs sevsstpeys vndsygeqec 121 recdgvfkcs ahfegapeyy ddetesgpal epmtsnsekd pfidvfldkl isrlvpeklp 181 erehfssktt iehdldtgrv pvfsattlgs nfkklskkmg sifelqdsiv rlltwrnptg 241 tvtslilftl icfnpmylvi lpifrfvygi vvpgyvrkhp lqrsiyplkr nhgssllydv 301 cyegkneysy gqqffsksfm dtlesrnqei deiseldkrt entgelkqgm kvlinlrdmq 361 nmtsgtlhvi eainsflrks ssfqneecst krfftgflli vflkilspfv nwsyvcsifa 421 wclliymhpr ahpkiisffk tgtmgkeykn lkkrehqaln mifdeqpetk fieifeiykk 481 allpndwkff rysnrifdpq dpyrraqqfp pgvdsladvi pptgwsfdpn fewkidndvd 541 rwvverglnl pitgeflfdp mfkrrrlihr viknatpva // LOCUS NP_012021 526 aa linear PLN 30-JUN-2025 DEFINITION Mtc6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012021 VERSION NP_012021.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179282.1 REFERENCE 1 (residues 1 to 526) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 526) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 526) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 526) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06844. Method: conceptual translation. FEATURES Location/Qualifiers source 1..526 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..526 /product="Mtc6p" /calculated_mol_wt="59688" CDS 1..526 /gene="MTC6" /locus_tag="YHR151C" /coded_by="NM_001179282.1:1..1581" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:38621657]" /experiment="EXISTENCE:mutant phenotype:GO:0071464 cellular response to hydrostatic pressure [PMID:38621657]" /note="ER-resident glycoprotein involved in high-pressure tolerance; proposed role promoting proper folding of nutrient permeases, such as Tat2p, in the ER during hydrostatic pressure stress and maintaining permease conformational stability; contains two transmembrane domains, a C-terminal cytoplasmic domain and a luminal region with 12 N-linked glycans; null is synthetically sick with cdc13-1; localizes to the ER membrane" /db_xref="GeneID:856556" /db_xref="SGD:S000001194" ORIGIN 1 mwiliylfii wsslrtwvta vdstttvgdd lnetvsasvw ptmspqmtva frsqrdvmgn 61 ltidqlpyvg lnlrrvllnn etsmvnegnn trlltlfksm lsseanafvl dleqynndlr 121 vvdttllfsd vltalqsfif stqnnlyani ivlllnisap eldsteyrhq nqtlnttyil 181 dknlgnsfiy kptdlqsdra knntwniygk ssidgwptlg svlyeqkkrl vigeltdffn 241 ettapyifph dvfhyeqgns tldcpstveg ltdlssihwr fldslfnsvd ikeyiscgls 301 piisnsayvn nvtqladiih egsvwswdsd qpsvtqstsk sgsssgtlea yncvllyyfa 361 nnetvtwrvg ncynsniglc ryenmafrwl vrsnkatyfd fdsyqgskcp dqysfniprs 421 pleqrsfiay mrnssfsdtq iwidlnsisv sncwvsggpy ascpyekvis rrnfvtmmvp 481 asvcsfallc ivvylsvlrv piydnrknwr rvinkiskse legvps // LOCUS NP_012022 173 aa linear PLN 30-JUN-2025 DEFINITION Spo12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012022 VERSION NP_012022.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179283.1 REFERENCE 1 (residues 1 to 173) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 173) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 173) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 173) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06845. Method: conceptual translation. FEATURES Location/Qualifiers source 1..173 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..173 /product="Spo12p" /calculated_mol_wt="19781" Region 117..151 /region_name="Spo12" /note="Spo12 family; pfam05032" /db_xref="CDD:398624" CDS 1..173 /gene="SPO12" /locus_tag="YHR152W" /gene_synonym="SDB21" /coded_by="NM_001179283.1:1..522" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10564265|PMID:11729145]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11729145]" /experiment="EXISTENCE:genetic interaction:GO:0031536 positive regulation of exit from mitosis [PMID:11832211]" /experiment="EXISTENCE:genetic interaction:GO:1904750 negative regulation of protein localization to nucleolus [PMID:14551257]" /experiment="EXISTENCE:mutant phenotype:GO:0007127 meiosis I [PMID:7021311]" /experiment="EXISTENCE:mutant phenotype:GO:0031536 positive regulation of exit from mitosis [PMID:27418100|PMID:11832211]" /experiment="EXISTENCE:mutant phenotype:GO:1904750 negative regulation of protein localization to nucleolus [PMID:14551257]" /note="Nucleolar hypothetical protein; positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis; SPO12 has a paralog, BNS1, that arose from the whole genome duplication" /db_xref="GeneID:856557" /db_xref="SGD:S000001195" ORIGIN 1 msnkasdqsa rtasilktdi trentitrss ssnndnyhhh nninnynesa ktgedanken 61 ipnleeeiaa frifrkksts nlksshttsn lvkktmfkrd llkqdpkrkl qlqqrfaspt 121 drlvspcslk lnehkvkmfg kkkkvnpmkl nfkgnlaads edveidedee yfy // LOCUS NP_012023 198 aa linear PLN 30-JUN-2025 DEFINITION Spo16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012023 VERSION NP_012023.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179284.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 198) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06846. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..198 /product="Spo16p" /calculated_mol_wt="23000" Region 23..196 /region_name="Spo16" /note="Spo16 protein; pfam19225" /db_xref="CDD:437059" CDS 1..198 /gene="SPO16" /locus_tag="YHR153C" /coded_by="NM_001179284.1:1..597" /experiment="EXISTENCE:direct assay:GO:0000217 DNA secondary structure binding [PMID:30566683]" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:30566683]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:18297071]" /experiment="EXISTENCE:mutant phenotype:GO:0010520 regulation of reciprocal meiotic recombination [PMID:18297071]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:2188099]" /experiment="EXISTENCE:mutant phenotype:GO:0033235 positive regulation of protein sumoylation [PMID:23326245]" /note="Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation" /db_xref="GeneID:856558" /db_xref="SGD:S000001196" ORIGIN 1 mseffwdvqk iqeisnveeh svvkcvtvnt srlisqlnee lqdeesgvnf ivtqlqllin 61 nvyekiqksp gvpahrslmi nlnftrlkfs iaywdiller sldlingpsk tgaryfitev 121 tpvdrsryve nnqyflafka nqrltrnsvd mdefidfeil ikqiifdlfk kngipdqdfe 181 ailsrfhnle slvvafne // LOCUS NP_012024 1070 aa linear PLN 30-JUN-2025 DEFINITION Rtt107p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012024 VERSION NP_012024.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179285.1 REFERENCE 1 (residues 1 to 1070) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1070) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1070) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1070) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1070) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1070) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1070) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06847. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1070 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1070 /product="Rtt107p" /calculated_mol_wt="122887" Region 117..213 /region_name="BRCT" /note="BRCA1 C Terminus (BRCT) domain; pfam00533" /db_xref="CDD:425736" Region 265..349 /region_name="BRCT" /note="breast cancer carboxy-terminal domain; smart00292" /db_xref="CDD:214602" Region 382..456 /region_name="BRCT" /note="C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; cl00038" /db_xref="CDD:469589" Region <580..824 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" Region 830..914 /region_name="RTT107_BRCT_5" /note="Regulator of Ty1 transposition protein 107 BRCT domain; pfam16770" /db_xref="CDD:465266" Region 948..1054 /region_name="RTT107_BRCT_6" /note="Regulator of Ty1 transposition protein 107 BRCT domain; pfam16771" /db_xref="CDD:435575" CDS 1..1070 /gene="RTT107" /locus_tag="YHR154W" /gene_synonym="ESC4" /coded_by="NM_001179285.1:1..3213" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:17978089]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0035361 Cul8-RING ubiquitin ligase complex [PMID:20139071]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:14988729]" /experiment="EXISTENCE:mutant phenotype:GO:0010526 transposable element silencing [PMID:11779788]" /experiment="EXISTENCE:mutant phenotype:GO:1903775 regulation of DNA double-strand break processing [PMID:26490958]" /experiment="EXISTENCE:mutant phenotype:GO:1990683 DNA double-strand break attachment to nuclear envelope [PMID:27056668]" /experiment="EXISTENCE:mutant phenotype:GO:2000001 regulation of DNA damage checkpoint [PMID:26490958]" /note="BRCA1 C-terminal domain protein needed for recovery from DNA damage; implicated in Mms22-dependent DNA repair during S phase; involved in recruiting SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition; relative distribution to nuclear foci increases upon DNA replication stress" /db_xref="GeneID:856559" /db_xref="SGD:S000001197" ORIGIN 1 mstsllfeql nflilvaaea elpiahstrk llmdnscnnc qiyelynenl kdvktdkdwf 61 mnkfgpqtvh fvisntinfp fykivyfdll ipvvshtwvq dsvktkrhlr tnmyspnpfh 121 llrdcqvyis kssfnkceyi lysdllhllg gtlvnyisnr tthvivqspq dpiiatvskl 181 tfgsfsssst nkhtekplre wkfvypiwil yhfkmakplk gelatlceld mqdtseeqlf 241 akweevigdk qtsssqltlh pnktlfknhh faispdlnff tplywflkgf iedldgkvtp 301 lsfsddlksv yqafpdidcy ighsanspil ektksikpei hvgnvswlfy mfalqkftpv 361 sqcklihqpf haklftskel tvaytnyfgs qrfyiqrlve ilgglstpel trknthlitk 421 stigkkfkva kkwsldpqna iivtnhmwle qcymnnskln pkdsrfqnfk lddnmgwnig 481 qigmdhsslp tpknlsmvty dtqsisekpp ptndqmdqin dntnvlskkd gtpissfens 541 idekidklqk isgevavths gdlersfvsr psrasfpvvd skksnlqkkd snsdismete 601 vfceghekre ekeftkpite ydapkkqeir eqsrkkndid ykkeeeetel qvqlgqrtkr 661 eiktskknek eketnechie vdqmtnekqg eestgklist edvtskkdtd kfshlfegls 721 dnddhindek pavnskyttp ktsqnitsgv dtpttaqtqv fmpssgnsrl aktqaakrlh 781 tdieslnefq knfkrkrids eeislsqdve rsnnnkelat kaekilarfn elpnydlkav 841 ctgcfhdgfn evdieilnql gikifdnike tdklncifap kilrtekflk slsfeplkfa 901 lkpefiidll kqihskkdkl sqininlfdy einginesii sktklptkvf eranircinl 961 vndipggvdt igsvlkahgi ekinvlrskk ctfediipnd vskqenggif kyvlivtkas 1021 qvkkftklin drdknetili vewnwcvesi fhlnvdftsk knvlyqkknn // LOCUS NP_012025 1228 aa linear PLN 30-JUN-2025 DEFINITION Lam1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012025 VERSION NP_012025.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179286.1 REFERENCE 1 (residues 1 to 1228) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1228) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1228) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1228) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06848. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1228 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1228 /product="Lam1p" /calculated_mol_wt="143453" Region 27..246 /region_name="BAR_SIP3_fungi" /note="The Bin/Amphiphysin/Rvs (BAR) domain of fungal Snf1p-interacting protein 3; cd07609" /db_xref="CDD:153293" Site order(35,38..39,43,45..46,49..50,52..53,57..58,60..61, 64..65,67..68,71,83,86..87,197,200..201,203..204,207..208, 210..211,214..215,218..219,221..222,233..234,236..237) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153293" Region 312..425 /region_name="PH_SIP3" /note="Snf1p-interacting protein 3 Pleckstrin homology (PH) domain; cd13280" /db_xref="CDD:270098" CDS 1..1228 /gene="LAM1" /locus_tag="YHR155W" /gene_synonym="YSP1" /coded_by="NM_001179286.1:1..3687" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15657396|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:26001273]" /experiment="EXISTENCE:mutant phenotype:GO:0032366 intracellular sterol transport [PMID:26001273]" /note="Putative sterol transfer protein; localizes to puncta in the cortical ER; probable role in retrograde transport of sterols from the plasma membrane to the ER; one of six StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; contains GRAM, StART-like (VASt) and two PH-like domains" /db_xref="GeneID:856560" /db_xref="SGD:S000001198" ORIGIN 1 mhehkaelrl itvalneast dspsfrasvn yfhtrmesls swmhstvdyv entykpsfqd 61 fqriketlfs qllpspills ngfvsnqpyt pllvrdftrd vsdlsntvmk iilgdensqy 121 taalsalssd ainpyfnkrk tfeyyqrkyd sfltdflaat ndgntlipqn lqnetfklvd 181 ikhkyieasl dlteaislmk vnldkfliet idivrknnvi ttkdtkdvid itpeltetlk 241 dwtdwiesnl qtlqalsskl seakyailkl slarmkpsrl iqdydlksiq nlkfnlpksi 301 sngnnseekg lsgwlymktt vghdpkrvvw vrrwcflqnn vfgvfslsps ktyveetdkf 361 gilwitveyl pkeprnfcfk lriqnpnckt eeentyidii lqaesidelk swintltshk 421 rialsikeen dpryqlarkk iepqffefas ssststdkll tsfssktltl veelkknyms 481 eddiysiidn kayhlrvist piatqlthla lfstflsvsn yypcatqant wgtanwndls 541 ylvnplkgss vhkpatvsns srfsvsypdy ypyslkvddi qfrsiffsvn hdflqvpkel 601 vllryssvwc pnnkqkfasm afvtlnhiyv ylnisgfsyl rridlldids ieydkspkhv 661 ssrmlhmqrg dglrfnmsvf ftdrravask lqflienkam hipkgekevl eifqeldeei 721 enekkiikdn lsesehyskd ydyllkstyd hhfentnetp melmsrklrl ereawcyfqd 781 nfkvgsktlf hvlfgdksqv fpsslflckk gsnlnnnsyw erirrakeda scqfelcrkl 841 qfqlnrtsnf ikdllwlkdd ndnfklvlqq rvtkikqgyy feveegpiiv kfplchplll 901 rvrfiiaeci tsqgeslkkc dlailydfny vesidklntk veklwlferi hlnwalryck 961 lehseinrkt reylkkfndr ekmsdviklc gflgvlpker iendekagdf mqpvyinydf 1021 lslskiftkl tvfylssvii ktmkvllamv mvifkcfskv nktlyyclli savtnlffvg 1081 ksihsyfsvk saetlfqnya ngdqrglqim hrsltvpdln lltrkmmdnd qenpvfkrfd 1141 edknayqykg trqeiaikrn qvltelkilq ntekelvqgs yrkfiiterd kcittqneif 1201 dlwindtklq dycmacfaey nrlsaipv // LOCUS NP_012026 340 aa linear PLN 30-JUN-2025 DEFINITION U5 snRNP complex subunit LIN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012026 VERSION NP_012026.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179287.1 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 340) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06849. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..340 /product="U5 snRNP complex subunit LIN1" /calculated_mol_wt="40238" Region 283..340 /region_name="GYF" /note="Contains conserved Gly-Tyr-Phe residues; smart00444" /db_xref="CDD:214666" CDS 1..340 /gene="LIN1" /locus_tag="YHR156C" /gene_synonym="SNU40" /coded_by="NM_001179287.1:1..1023" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12402242]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12402242]" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12402242]" /note="Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication" /db_xref="GeneID:856561" /db_xref="SGD:S000001199" ORIGIN 1 mkytqypnss klkrnsdrre hdeklsdelh nqstiyedee lsraeydsds dssvedstdn 61 ensgkemdek syeknedhve dhrkrkkski qlldiaefkk enladldyqi gnseskvekg 121 vniepfnidd eikhgvfdkd gnyiktenat endqqdneew mndvinteev nrlekeqsvk 181 tqnsrhymvh ealnllkffl vdenetvles lgrlnklrki aiskknkslk yvihgiells 241 dlinilekkg fsevyeynrl kvqdaieeei fddssrivnh ktklwgfkwl nkldeyhgly 301 tnyemsywqk syfknsvivk fhsepdrden wihvsclsfm // LOCUS NP_012027 182 aa linear PLN 30-JUN-2025 DEFINITION Rec104p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012027 VERSION NP_012027.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179288.1 REFERENCE 1 (residues 1 to 182) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 182) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 182) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 182) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06850. Method: conceptual translation. FEATURES Location/Qualifiers source 1..182 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..182 /product="Rec104p" /calculated_mol_wt="20613" Region 1..182 /region_name="REC104" /note="Meiotic recombination protein REC104; pfam17378" /db_xref="CDD:465407" CDS 1..182 /gene="REC104" /locus_tag="YHR157W" /coded_by="NM_001179288.1:1..549" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:15044957]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:9177999]" /note="Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination" /db_xref="GeneID:856562" /db_xref="SGD:S000001200" ORIGIN 1 msieeedtnk itctqdflhq yfvtervsiq fglnnktvkr inkdefdkav ncimswtnyp 61 kpglkrtast yllsnsfkks atvslpfilg dpvcmpkrve snnndtclly sdtlyddpli 121 qrndqagdei edefsftllr sevneirpis ssstaqilqs dysalmyerq asngsifqfs 181 sp // LOCUS NP_012028 1164 aa linear PLN 30-JUN-2025 DEFINITION Kel1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012028 VERSION NP_012028.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179289.1 REFERENCE 1 (residues 1 to 1164) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1164) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1164) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1164) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06851. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1164 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1164 /product="Kel1p" /calculated_mol_wt="130963" Region 117..417 /region_name="NanM" /note="N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; COG3055" /db_xref="CDD:442289" Region 125..179 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 182..233 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 237..293 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 299..345 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 347..396 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 777..>1097 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" CDS 1..1164 /gene="KEL1" /locus_tag="YHR158C" /coded_by="NM_001179289.1:1..3495" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:34965431]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:9786949]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9786949]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:23673619]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807|PMID:9786949]" /experiment="EXISTENCE:direct assay:GO:1990615 Kelch-containing formin regulatory complex [PMID:24828508]" /experiment="EXISTENCE:genetic interaction:GO:0032465 regulation of cytokinesis [PMID:24828508]" /experiment="EXISTENCE:genetic interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:24828508]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:9786949]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:12234925]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:34965431]" /experiment="EXISTENCE:mutant phenotype:GO:0008360 regulation of cell shape [PMID:9786949]" /experiment="EXISTENCE:mutant phenotype:GO:0060627 regulation of vesicle-mediated transport [PMID:24828508]" /experiment="EXISTENCE:mutant phenotype:GO:0090029 negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:34965431]" /note="Protein required for proper cell fusion and cell morphology; acts as phosphorylation-regulated noise suppressor of pheromone signaling pathway; forms a complex with Bud14p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate" /db_xref="GeneID:856563" /db_xref="SGD:S000001201" ORIGIN 1 magfsfakkf thkkhgktps dasisdqsre aslstppnek fftkqetpqk grqfsqgyhs 61 nvnktssppm farkqvsesr iqpsavppqq rnvsgpsttl hkqlskqrey tvwnriklqn 121 spfpryrhva sayvtdknqi yvigglhdqs vygdtwilta fdnatrfstt tidiseatpp 181 prvghaavlc gnafvvfggd thkvnkeglm dddiyllnin sykwtvpapv gprplgrygh 241 kisiiattqm ktklyvfggq fddtyfndla vydlssfrrp dshweflkpr tftpppitnf 301 tmisydsklw vfggdtlqgl vndvfmydpa indwfiidtt gekpppvqeh atvvyndlmc 361 vvggkdehda ylnsvyflnl ksrkwfklpv ftagipqgrs ghsltllknd kilimggdkf 421 dyarveeydl htsdidmqrg tivytldlar ikdlcpgvmd vptdtptprn gnldlatpvt 481 ptshqtknmn vpisaaplas apspapkdfs dadrlnrevh nrnvstehqn qshpvnsesh 541 liaepniltp yvpsessqtp vmkitsnkpf dtptiqkepd lsetmdptvg nqripssiyg 601 dnltpanqik nnspiletlp sneiktpqng nieeikhlpd adekidsttt fdqeingdkl 661 gtssmskvee dgnvadedde igvaqmassp skdqfkikhy nesselsqnn teidklsepv 721 ditikksdta ghdsanhvid asdeknvspm gdvptdtkne easvpinrda ttevvdralf 781 eklrselqsl kelthekale agahikelet elwqlksqkn sgttkeidel dsvrlqskce 841 ileadnhsle dkvneleelv nskfldienl neviqfqnek ikslelepny kekleelqie 901 henlsrener lkneskqhne diinnvanys sqlgslishw kenranssfl esssslisvs 961 dengektvge pygdqsrhhr vvinkltnrl ddllersqel tiskeklsse yhalkmehss 1021 lsqdvlvken eikkiqndyk esissmdsas kalmvsqrel ekykslnkkl ideldelkfk 1081 ngvcsenfen glrsteessn nvknsnsire nqfnikindl kaelfitnqe rddlksevle 1141 lkkrllnlen ntkqvnedad sdll // LOCUS NP_012029 504 aa linear PLN 30-JUN-2025 DEFINITION Tda11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012029 VERSION NP_012029.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179290.1 REFERENCE 1 (residues 1 to 504) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 504) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 504) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 504) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06852. Method: conceptual translation. FEATURES Location/Qualifiers source 1..504 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..504 /product="Tda11p" /calculated_mol_wt="56183" Region 3..451 /region_name="TDA11" /note="Topoisomerase I damage affected protein 11; pfam17084" /db_xref="CDD:407236" CDS 1..504 /gene="TDA11" /locus_tag="YHR159W" /coded_by="NM_001179290.1:1..1515" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele" /db_xref="GeneID:856564" /db_xref="SGD:S000001202" ORIGIN 1 mnkfdefies nekdldvdts trnsiismsp vrktgrkirs assngyrleh hrtssagsmh 61 sqrlmtptrl ndqdhplqak pdarrvvtrh ssvsvpnams krrsliqpmv vpttpesqnn 121 lpsvshsegs ygiplesttv lsseqamasg lrrsrngssq svnsmiatti ptngvdvsal 181 lqslatkele lleckqkied lkkqtqheeq nytrrarelh elkeqvskhl dpslntpvkn 241 rafspvyqni plesrtenag nsslpssvsk pknmghqstn qsrsvspqdi qerrqrddss 301 dsskqslwsk plalfnqfdk iiqheiertl nwddslsgtp evqegtptsn sessaqqydn 361 eapgarqksp sqgsvsrslw sfvsdvkagl lgieeendnd vitdnrcdpv yksdrqheqk 421 ksthkitnrg qaedsgddss lnmrkfkttt kfqkdnagnn sltdesghrt rekkskrssn 481 klsfigepdn dnssvknsve mtdf // LOCUS NP_012030 283 aa linear PLN 30-JUN-2025 DEFINITION Pex18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012030 VERSION NP_012030.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179291.1 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 283) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06853. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..283 /product="Pex18p" /calculated_mol_wt="31906" CDS 1..283 /gene="PEX18" /locus_tag="YHR160C" /coded_by="NM_001179291.1:1..852" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:9864360]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9864360]" /experiment="EXISTENCE:genetic interaction:GO:0016558 protein import into peroxisome matrix [PMID:9864360]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:9864360]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9864360]" /note="Peroxin; required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p; primarily responsible for peroxisomal import during growth on oleate, and expression is induced during oleate growth" /db_xref="GeneID:856565" /db_xref="SGD:S000001203" ORIGIN 1 mnsnrcqtne vnkfisstek gpftgrdntl sfnkigsrln sppilkdkie lkflqhsedl 61 nqsrsyvnir prtledqsyk feapnlndne tswakdfryn fpknveppie nqianlninn 121 glrtsqtdfp lgfysqknfn iasfpvvdhq ifkttglehp inshidslin aefseleass 181 leedvhteee nsgtsledee tamkglasdi iefcdnnsan kdvkerlnss kfmglmgsis 241 dgsivlkkdn gternlqkhv gfcfqnsgnw aglefhdved ria // LOCUS NP_012031 637 aa linear PLN 30-JUN-2025 DEFINITION Yap1801p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012031 VERSION NP_012031.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179292.1 REFERENCE 1 (residues 1 to 637) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 637) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 637) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 637) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06854. Method: conceptual translation. FEATURES Location/Qualifiers source 1..637 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..637 /product="Yap1801p" /calculated_mol_wt="71529" Region 3..269 /region_name="ANTH" /note="ANTH domain; pfam07651" /db_xref="CDD:400137" Site order(10,20,22..23) /site_type="other" /note="putative PtdIns(4,5)P2-binding site [chemical binding]" /db_xref="CDD:340785" CDS 1..637 /gene="YAP1801" /locus_tag="YHR161C" /coded_by="NM_001179292.1:1..1914" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:33443082]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:9531549]" /experiment="EXISTENCE:physical interaction:GO:0006897 endocytosis [PMID:9531549]" /note="Protein of the AP180 family, involved in clathrin cage assembly; binds Pan1p and clathrin; YAP1801 has a paralog, YAP1802, that arose from the whole genome duplication" /db_xref="GeneID:856566" /db_xref="SGD:S000001204" ORIGIN 1 mttyfklvkg atkiksappk qkyldpillg tsneedfyei vkgldsrind tawtivyksl 61 lvvhlmireg skdvalryys rnleffdien irgsngsasg dmraldrydn ylkvrcrefg 121 kikkdyvrdg yrtlklnsgn ygssrnkqhs inialdhves levqiqalik nkytqydlsn 181 eliifgfkll iqdllalyna lnegiitlle sffelshhna ertldlyktf vdltehvvry 241 lksgktaglk ipvikhittk lvrsleehli eddkthntfv pvdssqgsag avvakstaqe 301 rleqireqkr ileaqlkneq vaispalttv taaqsynpfg tdssmhtnip mavanqtqqi 361 annpfvsqtq pqvmntptah tepanlnvpe yaavqhtvnf npvqdagvsa qqtgyysinn 421 hltptftgag fggysvsqdt taasnqqvsh sqtgsnnpfa lhnaatiatg npahenvlnn 481 pfsrpnfdeq ntnmplqqqi isnpfqnqty nqqqfqqqkm plssinsvmt tptsmqgsmn 541 ipqrfdkmef qahytqnhlq qqqqqqqqqq qqqqqqpqqg yyvpatagan pvtnitgtvq 601 pqnfpfypqq qpqpeqsqtq qpvlgnqyan nlnlidm // LOCUS NP_012032 129 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial pyruvate carrier [Saccharomyces cerevisiae S288C]. ACCESSION NP_012032 VERSION NP_012032.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179293.1 REFERENCE 1 (residues 1 to 129) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 129) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 129) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 129) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06855. Method: conceptual translation. FEATURES Location/Qualifiers source 1..129 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..129 /product="mitochondrial pyruvate carrier" /calculated_mol_wt="14424" Region 9..118 /region_name="MPC" /note="Mitochondrial pyruvate carriers; pfam03650" /db_xref="CDD:427425" CDS 1..129 /gene="MPC2" /locus_tag="YHR162W" /coded_by="NM_001179293.1:1..390" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:22628558]" /experiment="EXISTENCE:direct assay:GO:0006850 pyruvate import into mitochondria [PMID:25672363]" /experiment="EXISTENCE:direct assay:GO:0050833 pyruvate transmembrane transporter activity [PMID:25672363]" /experiment="EXISTENCE:genetic interaction:GO:0006850 pyruvate import into mitochondria [PMID:22628554]" /experiment="EXISTENCE:mutant phenotype:GO:0006850 pyruvate import into mitochondria [PMID:22628558]" /experiment="EXISTENCE:physical interaction:GO:0050833 pyruvate transmembrane transporter activity [PMID:22628558]" /note="Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on fermentable carbon sources, and heterodimerizes with Mpc1p to form the fermentative isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC2 paralog, MPC3, heterodimerizes with Mpc1p to form the respiratory MPC isoform" /db_xref="GeneID:856567" /db_xref="SGD:S000001205" ORIGIN 1 mstssvrfaf rrfwqsetgp ktvhfwaptl kwglvfagfs dmkrpvekis gaqnlsllst 61 aliwtrwsfv ikprnillas vnsflcltag yqlgrianyr irngdsisql csyilsgade 121 skkeittgr // LOCUS NP_012033 249 aa linear PLN 30-JUN-2025 DEFINITION 6-phosphogluconolactonase SOL3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012033 VERSION NP_012033.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179294.1 REFERENCE 1 (residues 1 to 249) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 249) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 249) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 249) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06856. On Nov 30, 2005 this sequence version replaced NP_012033.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..249 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..249 /product="6-phosphogluconolactonase SOL3" /EC_number="3.1.1.31" /calculated_mol_wt="27653" Region 6..244 /region_name="pgl" /note="6-phosphogluconolactonase; TIGR01198" /db_xref="CDD:273494" Site order(43..44,75,147,181,204) /site_type="active" /note="putative active site [active]" /db_xref="CDD:238694" CDS 1..249 /gene="SOL3" /locus_tag="YHR163W" /coded_by="NM_001179294.1:1..750" /experiment="EXISTENCE:curator inference:GO:0009051 pentose-phosphate shunt, oxidative branch [PMID:15454531]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0017057 6-phosphogluconolactonase activity [PMID:15454531]" /note="6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication" /db_xref="GeneID:856568" /db_xref="SGD:S000001206" ORIGIN 1 mvtvgvfser aslthqlgef ivkkqdealq kksdfkvsvs ggslidalye slvadeslss 61 rvqwskwqiy fsderivplt dadsnygafk ravldklpst sqpnvypmde sligsdaesn 121 nkiaaeyeri vpqvldlvll gcgpdghtcs lfpgethryl lnettkrvaw chdspkppsd 181 ritftlpvlk dakalcfvae gsskqnimhe ifdlkndqlp talvnklfge ktswfvneea 241 fgkvqtktf // LOCUS NP_012034 1522 aa linear PLN 30-JUN-2025 DEFINITION bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012034 VERSION NP_012034.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179295.1 REFERENCE 1 (residues 1 to 1522) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1522) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1522) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1522) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06857. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1522 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1522 /product="bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2" /EC_number="3.6.4.12" /calculated_mol_wt="171564" Region 444..662 /region_name="Dna2" /note="DNA replication factor Dna2; pfam08696" /db_xref="CDD:462565" Region <645..779 /region_name="Cas4" /note="CRISPR/Cas system-associated exonuclease Cas4, RecB family [Defense mechanisms]; COG1468" /db_xref="CDD:441077" Region <1049..1464 /region_name="TIGR00376" /note="DNA helicase, putative" /db_xref="CDD:273041" Region 1052..1253 /region_name="DEXXQc_DNA2" /note="DEXXQ-box helicase domain of DNA2; cd18041" /db_xref="CDD:350799" Site order(1052..1053,1056,1079..1082,1114,1252..1253) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350799" Site order(1103..1105,1164,1166,1218) /site_type="other" /note="nucleic acid binding site [nucleotide binding]" /db_xref="CDD:350799" CDS 1..1522 /gene="DNA2" /locus_tag="YHR164C" /gene_synonym="WEB2" /coded_by="NM_001179295.1:1..4569" /experiment="EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:9756935|PMID:23671118]" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:32638513]" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:12024033]" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:7644470]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:19520826]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19520826]" /experiment="EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:9710536]" /experiment="EXISTENCE:direct assay:GO:0017108 5'-flap endonuclease activity [PMID:15448135]" /experiment="EXISTENCE:direct assay:GO:0032448 DNA hairpin binding [PMID:23344960]" /experiment="EXISTENCE:direct assay:GO:0043539 protein serine/threonine kinase activator activity [PMID:23355394]" /experiment="EXISTENCE:genetic interaction:GO:0000706 meiotic DNA double-strand break processing [PMID:20150422]" /experiment="EXISTENCE:genetic interaction:GO:0000729 DNA double-strand break processing [PMID:21841787]" /experiment="EXISTENCE:genetic interaction:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:23355394]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:12024033]" /experiment="EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:18805091]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:7592912]" /experiment="EXISTENCE:mutant phenotype:GO:0006273 lagging strand elongation [PMID:10330154|PMID:10101169]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:10101169]" /experiment="EXISTENCE:mutant phenotype:GO:0032448 DNA hairpin binding [PMID:23344960]" /experiment="EXISTENCE:mutant phenotype:GO:0043539 protein serine/threonine kinase activator activity [PMID:23355394]" /note="ATP-dependent 5'-flap endonuclease and DNA helicase; tracking protein for flap cleavage during Okazaki fragment maturation; involved in DNA repair/processing of meiotic DNA double strand breaks; cell cycle-dependent localization to telomeric chromatin and replicating chromosomes; required for telomerase-dependent telomere synthesis; stability, localization and nuclease activity regulated by sumoylation; forms nuclear foci upon replication stress; human homolog DNA2 complements yeast dna2 mutant" /db_xref="GeneID:856569" /db_xref="SGD:S000001207" ORIGIN 1 mpgtpqknkr sasisvspak kteekeiiqn dskailskqt krkkkyafap innlngkntk 61 vsnasvlksi avsqvrntsr tkdinkavsk svkqlpnsqv kpkremsnls rhhdftqded 121 gpmeeviwky splqrdmsdk ttsaaeysdd yedvqnpsst pivpnrlktv lsftniqvpn 181 advnqliqen gneqvrpkpa eistreslrn iddilddieg dltikptitk fsdlpsspik 241 apnvekkaev naeevdkmds tgdsndgdds lidiltqkyv ekrksesqit iqgntnqksg 301 aqescgkndn tksrgeiedh envdnqaktg nafyeneeds ncqrikknek ieynssdefs 361 ddsliellne tqtqvepnti eqdldkvekm vsddlriatd stlsayalra ksgaprdgvv 421 rlvivslrsv elpkigtqki lecidgkgeq ssvvvrhpwv ylefevgdvi hiiegknien 481 krllsddknp ktqlandnll vlnpdvlfsa tsvgssvgcl rrsilqmqfq dprgepslvm 541 tlgnivhell qdsikyklsh nkismeiiiq kldslletys fsiiicneei qyvkelvmke 601 haenilyfvn kfvsksnygc ytsisgtrrt qpisisnvid ieeniwspiy glkgfldatv 661 eanvennkkh ivplevktgk srsvsyevqg liytlllndr yeipieffll yftrdknmtk 721 fpsvlhsikh ilmsrnrmsm nfkhqlqevf gqaqsrfelp pllrdsscds cfikescmvl 781 nklledgtpe esglvegefe iltnhlsqnl anykefftky ndlitkeess itcvnkelfl 841 ldgstresrs grclsglvvs evvehekteg ayiycfsrrr ndnnsqsmls sqiaandfvi 901 isdeeghfcl cqgrvqfinp akigisvkrk llnnrlldke kgvttiqsvv eseleqssli 961 atqnlvtyri dkndiqqsls larfnllslf lpavspgvdi vdersklcrk tkrsdggnei 1021 lrsllvdnra pkfrdanddp vipyklskdt tlnlnqkeai dkvmraedya lilgmpgtgk 1081 ttviaeiiki lvsegkrvll tsythsavdn iliklrntni simrlgmkhk vhpdtqkyvp 1141 nyasvksynd ylskinstsv vattclgind ilftlnekdf dyvildeasq ismpvalgpl 1201 rygnrfimvg dhyqlpplvk ndaarlggle eslfktfcek hpesvaeltl qyrmcgdivt 1261 lsnfliydnk lkcgnnevfa qslelpmpea lsryrnesan skqwledile ptrkvvflny 1321 dncpdiieqs ekdnitnhge aeltlqcveg mllsgvpced igvmtlyraq lrllkkifnk 1381 nvydgleilt adqfqgrdkk ciiismvrrn sqlnggallk elrrvnvamt rakskliiig 1441 skstigsvpe iksfvnllee rnwvytmckd alykykfpdr snaidearkg cgkrtgakpi 1501 tskskfvsdk piikeilqey es // LOCUS NP_012035 2413 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit PRP8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012035 VERSION NP_012035.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179296.1 REFERENCE 1 (residues 1 to 2413) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2413) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2413) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 2413) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06858. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2413 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..2413 /product="U4/U6-U5 snRNP complex subunit PRP8" /calculated_mol_wt="279374" Region 82..2413 /region_name="PRP8" /note="U5 snRNP spliceosome subunit [RNA processing and modification]; COG5178" /db_xref="CDD:227505" CDS 1..2413 /gene="PRP8" /locus_tag="YHR165C" /gene_synonym="DBF3; DNA39; RNA8; SLT21; USA2" /coded_by="NM_001179296.1:1..7242" /experiment="EXISTENCE:direct assay:GO:0000244 spliceosomal tri-snRNP complex assembly [PMID:23393194]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:17934474]" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284|PMID:17934474|PMID:11720285]" /experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:23393194]" /experiment="EXISTENCE:direct assay:GO:0030619 U1 snRNA binding [PMID:23393194]" /experiment="EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:23393194]" /experiment="EXISTENCE:direct assay:GO:0030623 U5 snRNA binding [PMID:23393194|PMID:9848662]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:17934474|PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:direct assay:GO:0097157 pre-mRNA intronic binding [PMID:23393194]" /experiment="EXISTENCE:mutant phenotype:GO:0000244 spliceosomal tri-snRNP complex assembly [PMID:17934474]" /experiment="EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:26968627|PMID:22408182]" /experiment="EXISTENCE:mutant phenotype:GO:0000386 second spliceosomal transesterification activity [PMID:17626844]" /experiment="EXISTENCE:mutant phenotype:GO:0000389 mRNA 3'-splice site recognition [PMID:10628969]" /experiment="EXISTENCE:mutant phenotype:GO:0000395 mRNA 5'-splice site recognition [PMID:29487104]" /note="Component of U4/U6-U5 snRNP complex; involved in second catalytic step of splicing; participates in spliceosomal assembly through its interaction with U1 snRNA; largest and most evolutionarily conserved protein of the spliceosome; mutations in human ortholog, PRPF8, cause Retinitis pigmentosa and missplicing in Myelodysplastic syndrome; mouse ortholog interacts with androgen receptor and may have a role in prostate cancer" /db_xref="GeneID:856570" /db_xref="SGD:S000001208" ORIGIN 1 msglpppppg feedsdlalp pppppppgye ieeldnpmvp ssvnedtflp ppppppsnfe 61 inaeeivdft lpppppppgl deletkaekk velhgkrkld igkdtfvtrk srkrakkmtk 121 kakrsnlytp kaemppehlr kiinthsdma skmyntdkka flgalkylph ailkllenmp 181 hpweqakevk vlyhtsgait fvnetprvie pvytaqwsat wiamrrekrd rthfkrmrfp 241 pfdddeppls yeqhieniep ldpinlplds qddeyvkdwl ydsrpleeds kkvngtsykk 301 wsfdlpemsn lyrlstplrd evtdknyyyl fdkksffngk alnnaipggp kfeplypree 361 eedynefnsi drvifrvpir seykvafphl ynsrprsvri pwynnpvsci iqndeeydtp 421 alffdpslnp iphfidnnss lnvsntkeng dftlpedfap llaeeeelil pntkdamsly 481 hspfpfnrtk gkmvraqdva lakkwflqhp deeypvkvkv syqkllknyv lnelhptlpt 541 nhnktkllks lkntkyfqqt tidwveaglq lcrqghnmln llihrkglty lhldynfnlk 601 ptktlttker kksrlgnsfh lmrellkmmk livdthvqfr lgnvdafqla dgihyilnhi 661 gqltgiyryk ykvmhqirac kdlkhiiyyk fnknlgkgpg cgfwqpawrv wlnflrgtip 721 lleryignli trqfegrsne ivktttkqrl dayydlelrn svmddilemm pesirqkkar 781 tilqhlseaw rcwkanipwd vpgmpapikk iieryikska dawvsaahyn rerikrgahv 841 ektmvkknlg rltrlwikne qerqrqiqkn gpeitpeeat tifsvmvewl esrsfspipf 901 ppltykndtk ilvlaledlk dvyaskvrln asereelali eeaydnphdt lnrikkyllt 961 qrvfkpvdit mmenyqnisp vysvdpleki tdayldqylw yeadqrklfp nwikpsdsei 1021 ppllvykwtq ginnlseiwd vsrgqsavll ettlgemaek idftllnrll rlivdpniad 1081 yitaknnvvi nfkdmshvnk yglirglkfa sfifqyyglv idllllgqer atdlagpann 1141 pnefmqfksk evekahpirl ytryldriym lfhfeedege eltdeylaen pdpnfensig 1201 ynnrkcwpkd srmrlirqdv nlgravfwei qsrvptslts ikwenafvsv ysknnpnllf 1261 smcgfevril prqrmeevvs ndegvwdlvd ertkqrtaka ylkvseeeik kfdsrirgil 1321 masgsttftk vaakwntsli slftyfreai vateplldil vkgetriqnr vklglnskmp 1381 trfppavfyt pkelgglgmi sashilipas dlswskqtdt githfragmt hedeklipti 1441 fryittwene fldsqrvwae yatkrqeaiq qnrrlafeel egswdrgipr istlfqrdrh 1501 tlaydrghri rrefkqysle rnspfwwtns hhdgklwnln ayrtdviqal ggietileht 1561 lfkgtgfnsw eglfwekasg fedsmqfkkl thaqrtglsq ipnrrftlww sptinranvy 1621 vgflvqldlt giflhgkipt lkisliqifr ahlwqkihes ivfdicqild geldvlqies 1681 vtketvhprk sykmnssaad itmesvhewe vskpsllhet ndsfkglitn kmwfdvqlry 1741 gdydshdisr yvrakfldyt tdnvsmypsp tgvmigidla ynmydaygnw fnglkpliqn 1801 smrtimkanp alyvlrerir kglqiyqssv qepflnssny aelfnndikl fvddtnvyrv 1861 tvhktfegnv atkaingcif tlnpktghlf lkiihtsvwa gqkrlsqlak wktaeevsal 1921 vrslpkeeqp kqiivtrkam ldplevhmld fpniairpte lrlpfsaams idklsdvvmk 1981 atepqmvlfn iyddwldris sytafsrltl llralktnee sakmillsdp titiksyhlw 2041 psftdeqwit iesqmrdlil teygrkynvn isaltqteik diilgqnika psvkrqkmae 2101 leaarsekqn deeaagastv mktktinaqg eeivvvasad yesqtfsskn ewrksaiant 2161 llylrlkniy vsaddfveeq nvyvlpknll kkfieisdvk iqvaafiygm sakdhpkvke 2221 iktvvlvpql ghvgsvqisn ipdigdlpdt eglellgwih tqteelkfma asevathskl 2281 fadkkrdcid isifstpgsv slsaynltde gyqwgeenkd imnvlsegfe ptfsthaqll 2341 lsdritgnfi ipsgnvwnyt fmgtafnqeg dynfkygipl efynemhrpv hflqfselag 2401 deeleaeqid vfs // LOCUS NP_012036 626 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit CDC23 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012036 VERSION NP_012036.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179297.1 REFERENCE 1 (residues 1 to 626) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 626) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 626) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 626) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 626) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 626) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 626) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06859. Method: conceptual translation. FEATURES Location/Qualifiers source 1..626 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..626 /product="anaphase promoting complex subunit CDC23" /calculated_mol_wt="72983" Region 12..144 /region_name="ANAPC8" /note="Anaphase promoting complex subunit 8 / Cdc23; pfam04049" /db_xref="CDD:427675" Region 306..427 /region_name="BepA" /note="Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones]; COG4783" /db_xref="CDD:443813" Region 391..>554 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" Region 397..425 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 433..459 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(435..436,439..440,442,466,469..470,473..474,476..477, 500,503..504,507..508,511) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 464..494 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 499..527 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 536..564 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..626 /gene="CDC23" /locus_tag="YHR166C" /coded_by="NM_001179297.1:1..1881" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:direct assay:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:8895471]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]" /experiment="EXISTENCE:physical interaction:GO:0030332 cyclin binding [PMID:12413490]" /note="Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition" /db_xref="GeneID:856571" /db_xref="SGD:S000001209" ORIGIN 1 mnddsqdkii hdiriqlrka atelsrwkly gsskwaaeal aglaeaidvd qthsladesp 61 lrnkqgvpkq mfeipqngfg lseteydlyl lgstlfdake fdrcvfflkd vtnpylkflk 121 lyskflswdk ksqesmenil ttgkftdemy rankdgdgsg nedinqsghq ranlkmvsne 181 hesqsnissi lkeintfles yeikidddea dlglallyyl rgvilkqekn iskamssflk 241 slscysfnws cwlelmdclq kvddalllnn ylyqnfqfkf senlgsqrti efnimikffk 301 lkvfeelngq ledyfedlef llqvfpnftf lkaynatisy nnldyvtaes rfddivkqdp 361 yrlndletys nilyvmqkns klaylaqfvs qidrfrpetc ciianyysar qeheksimyf 421 rraltldkkt tnawtlmghe fvelsnshaa iecyrravdi cprdfkawfg lgqayalldm 481 hlyslyyfqk actlkpwdrr iwqvlgecys ktgnkveaik cykrsikasq tvdqntsiyy 541 rlaqlyeele dlqeckkfmm kcvdveelle givtdetvka rlwlaifeik agnyqlaydy 601 amgvssgtsq eieearmlar ecrrhm // LOCUS NP_012037 261 aa linear PLN 30-JUN-2025 DEFINITION Thp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012037 VERSION NP_012037.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179298.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 261) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06860. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..261 /product="Thp2p" /calculated_mol_wt="30168" Region 115..243 /region_name="THP2" /note="Tho complex subunit THP2; pfam09432" /db_xref="CDD:401405" CDS 1..261 /gene="THP2" /locus_tag="YHR167W" /coded_by="NM_001179298.1:1..786" /experiment="EXISTENCE:direct assay:GO:0003676 nucleic acid binding [PMID:12093753]" /experiment="EXISTENCE:mutant phenotype:GO:0000445 THO complex part of transcription export complex [PMID:11979277]" /experiment="EXISTENCE:mutant phenotype:GO:0000446 nucleoplasmic THO complex [PMID:11060033]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:11060033]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:12093753]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:11979277]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:27251550]" /experiment="EXISTENCE:mutant phenotype:GO:0097185 cellular response to azide [PMID:27251550]" /note="Subunit of the THO and TREX complexes; THO connects transcription elongation and mitotic recombination, and TREX is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance" /db_xref="GeneID:856572" /db_xref="SGD:S000001210" ORIGIN 1 mtkeegrtyf eslceeeqsl qesqthllni ldilsvladp rssddlltes lkklpdlhre 61 linssirlry dkyqtreaql ledtktgrdv aagvqnpksi seyystfehl nrdtlryinl 121 lkrlsvdlak qvevsdpsvt vyemdkwvps eklqgileqy capdtdirgv daqiknyldq 181 ikmarakfgl enkyslkerl stltkelnhw rkewddieml mfgddahsmk kmiqkidslk 241 seinapsesy pvdkegdivl e // LOCUS NP_012038 518 aa linear PLN 30-JUN-2025 DEFINITION putative GTPase MTG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012038 VERSION NP_012038.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179299.2 REFERENCE 1 (residues 1 to 518) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 518) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 518) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 518) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06861. On Apr 26, 2011 this sequence version replaced NP_012038.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..518 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..518 /product="putative GTPase MTG2" /calculated_mol_wt="57716" Region 91..509 /region_name="Obg_CgtA" /note="Obg family GTPase CgtA; TIGR02729" /db_xref="CDD:274271" CDS 1..518 /gene="MTG2" /locus_tag="YHR168W" /coded_by="NM_001179299.2:1..1557" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15591131]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:15591131]" /experiment="EXISTENCE:mutant phenotype:GO:1902775 mitochondrial large ribosomal subunit assembly [PMID:15591131]" /note="Putative GTPase; member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly" /db_xref="GeneID:856573" /db_xref="SGD:S000001211" ORIGIN 1 msiawssvfk relrlerflp rvystkvpdn apraadneqw letlrpithp eqkksdhdvs 61 ytrhinvplg evtsvnylqr ynkhkhsqgn fvdvrivkck sgaggsgavs ffrdagrsig 121 ppdggdggag gsvyiqavag lgslakmktt ytaedgeaga arqldgmrgr dvliqvpvgt 181 vvkwclppqk vrelveremr kdnnatlrsi lgstavnlsv ssgshrkkiq lyrhemaesw 241 lfkdkakeyh enkdwfkdlh kkmeaydhsl eqselfndqf plagldlnqp mtkpvcllkg 301 gqgglgnmhf ltnlirnprf skpgrngleq hflfelksia dlgliglpna gkstilnkis 361 nakpkighwq fttlsptigt vslgfgqdvf tvadipgiiq gasldkgmgl eflrhiersn 421 gwvfvldlsn knplndlqll ieevgtlekv ktknilivcn kvdidaekse sfakylqvek 481 fsksqewdcv pisalreeni dvlkkkmfkc arqsefdk // LOCUS NP_012039 431 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase DBP8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012039 VERSION NP_012039.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179300.1 REFERENCE 1 (residues 1 to 431) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 431) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 431) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 431) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06862. Method: conceptual translation. FEATURES Location/Qualifiers source 1..431 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..431 /product="ATP-dependent RNA helicase DBP8" /EC_number="3.6.4.13" /calculated_mol_wt="47748" Region 1..428 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..431 /gene="DBP8" /locus_tag="YHR169W" /coded_by="NM_001179300.1:1..1296" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11222764]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:16772403]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11222764]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11222764]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11222764]" /experiment="EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:11222764]" /note="ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p" /db_xref="GeneID:856574" /db_xref="SGD:S000001212" ORIGIN 1 madfkslgls kwlteslram kitqptaiqk acipkilegr dciggaktgs gktiafagpm 61 ltkwsedpsg mfgvvltptr elamqiaeqf talgssmnir vsvivggesi vqqaldlqrk 121 phfiiatpgr lahhimssgd dtvgglmrak ylvldeadil ltstfadhla tcisalppkd 181 krqtllftat itdqvkslqn apvqkgkppl fayqvesvdn vaipstlkie yilvpehvke 241 aylyqlltce eyenktaiif vnrtmtaeil rrtlkqlevr vaslhsqmpq qertnslhrf 301 ranaarilia tdvasrgldi ptvelvvnyd ipsdpdvfih rsgrtaragr igdaisfvtq 361 rdvsriqaie drinkkmtet nkvhdtavir kaltkvtkak reslmamqke nfgerkrqqk 421 kkqndgkslr s // LOCUS NP_012040 518 aa linear PLN 30-JUN-2025 DEFINITION ribosome-binding protein NMD3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012040 VERSION NP_012040.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179301.1 REFERENCE 1 (residues 1 to 518) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 518) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 518) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 518) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06863. Method: conceptual translation. FEATURES Location/Qualifiers source 1..518 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..518 /product="ribosome-binding protein NMD3" /calculated_mol_wt="58964" Region 19..248 /region_name="NMD3" /note="NMD3 family; pfam04981" /db_xref="CDD:461505" CDS 1..518 /gene="NMD3" /locus_tag="YHR170W" /gene_synonym="SRC5" /coded_by="NM_001179301.1:1..1557" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10022925]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:11086007|PMID:11313466]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:11105761|PMID:17347149]" /experiment="EXISTENCE:direct assay:GO:0070180 large ribosomal subunit rRNA binding [PMID:24240281]" /experiment="EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:23212245]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11086007]" /note="Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex" /db_xref="GeneID:856575" /db_xref="SGD:S000001213" ORIGIN 1 meftpidphq hqnaatllcc ncgtpidgst glvmcydcik ltvditqgip reanisfcrn 61 cerflqppgq wiraelesre llaiclrrlk gltkvrlvda sfiwtephsr ririkltvqg 121 eamtntiiqq tfeveyivia mqcpdcarsy ttntwratvq irqkvphkrt flfleqlilk 181 hnahvdtisi seakdgldff yaqknhavkm idflnavvpi khkkseelis qdthtgasty 241 kfsysveivp ickddlvvlp kklaksmgni sqfvlcskis ntvqfmdptt lqtadlspsv 301 ywrapfnala dvtqlvefiv ldvdstgisr gnrvladitv artsdlgvnd qvyyvrshlg 361 gichagdsvm gyfiansnyn sdlfdglnid yvpdvvlvkk lyqrkskksr hwklkrmake 421 hkdidasldy nsraqkqeme raekdyelfl qeleedaelr qsvnlyknre anvppeehem 481 dedededapq inidelldel demtledgve ntpvesqq // LOCUS NP_012041 630 aa linear PLN 30-JUN-2025 DEFINITION Atg7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012041 VERSION NP_012041.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179302.1 REFERENCE 1 (residues 1 to 630) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 630) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 630) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 630) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06864. Method: conceptual translation. FEATURES Location/Qualifiers source 1..630 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..630 /product="Atg7p" /calculated_mol_wt="71297" Region 9..628 /region_name="E1_like_apg7" /note="E1-like protein-activating enzyme Gsa7p/Apg7p; TIGR01381" /db_xref="CDD:273590" CDS 1..630 /gene="ATG7" /locus_tag="YHR171W" /gene_synonym="APG11; APG7; CVT2" /coded_by="NM_001179302.1:1..1893" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10233150|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006501 C-terminal protein lipidation [PMID:19398890|PMID:15277523]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:10233148]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006501 C-terminal protein lipidation [PMID:15277523|PMID:11100732|PMID:12965207|PMID:11038174]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:23382696]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:10233150|PMID:12965207]" /experiment="EXISTENCE:mutant phenotype:GO:0019778 Atg12 activating enzyme activity [PMID:10233150]" /experiment="EXISTENCE:mutant phenotype:GO:0019779 Atg8 activating enzyme activity [PMID:11100732]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:10233150|PMID:12965207]" /experiment="EXISTENCE:mutant phenotype:GO:0032446 protein modification by small protein conjugation [PMID:10233150]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /note="Autophagy-related protein and dual specificity member of the E1 family; mediates the attachment of Atg12p to Atg5p and Atg8p to phosphatidylethanolamine which are required steps in autophagosome formation; E1 enzymes are also known as ubiquitin-activating enzymes; involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner" /db_xref="GeneID:856576" /db_xref="SGD:S000001214" ORIGIN 1 msservlsya pafksfldts ffqelsrlkl dvlkldstcq pltvnldlhn ipksadqvpl 61 fltnrsfekh nnkrtnevpl qgsifnfnvl defknldkql flhqralecw edgikdinkc 121 vsfviisfad lkkyrfyywl gvpcfqrpss tvlhvrpeps lkglfskcqk wfdvnyskwv 181 cildaddeiv nydkciirkt kvlairdtst menvpsaltk nflsvlqydv pdlidfklli 241 irqnegsfal natfasidpq ssssnpdmkv sgwernvqgk laprvvdlss lldplkiadq 301 svdlnlklmk wrilpdlnld iikntkvlll gagtlgcyvs raliawgvrk itfvdngtvs 361 ysnpvrqaly nfedcgkpka elaaaslkri fplmdatgvk lsipmighkl vneeaqhkdf 421 drlralikeh diifllvdsr esrwlpslls nienktvina algfdsylvm rhgnrdeqss 481 kqlgcyfchd vvaptdsltd rtldqmctvt rpgvammass lavelmtsll qtkysgsett 541 vlgdiphqir gflhnfsilk letpayehcp acspkvieaf tdlgwefvkk alehplylee 601 isglsvikqe verlgndvfe weddesdeia // LOCUS NP_012042 823 aa linear PLN 30-JUN-2025 DEFINITION gamma-tubulin-complex subunit SPC97 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012042 VERSION NP_012042.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179303.1 REFERENCE 1 (residues 1 to 823) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 823) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 823) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 823) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 823) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 823) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 823) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06865. Method: conceptual translation. FEATURES Location/Qualifiers source 1..823 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..823 /product="gamma-tubulin-complex subunit SPC97" /calculated_mol_wt="96694" Region 60..410 /region_name="GCP_N_terminal" /note="Gamma tubulin complex component N-terminal; pfam17681" /db_xref="CDD:465456" Region <560..>653 /region_name="GCP_C_terminal" /note="Gamma tubulin complex component C-terminal; pfam04130" /db_xref="CDD:461187" CDS 1..823 /gene="SPC97" /locus_tag="YHR172W" /coded_by="NM_001179303.1:1..2472" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005822 inner plaque of spindle pole body [PMID:9215630|PMID:9130700]" /experiment="EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:9130700|PMID:9215630]" /experiment="EXISTENCE:direct assay:GO:0007020 microtubule nucleation [PMID:24842996|PMID:11950928]" /experiment="EXISTENCE:direct assay:GO:0008275 gamma-tubulin small complex [PMID:9130700|PMID:25599398|PMID:9384578]" /experiment="EXISTENCE:mutant phenotype:GO:0031122 cytoplasmic microtubule organization [PMID:9670012]" /experiment="EXISTENCE:physical interaction:GO:0008275 gamma-tubulin small complex [PMID:9130700]" /experiment="EXISTENCE:physical interaction:GO:0043015 gamma-tubulin binding [PMID:9130700]" /note="Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque" /db_xref="GeneID:856577" /db_xref="SGD:S000001215" ORIGIN 1 meikevddra ellrytnnip llgklvnhqp lwstnpklks fslekisapd qrrvqealvv 61 kdllnvligl egtyiryfnd yepsdpetpi efkiakkmdp sfktfsrriv rygkqymilt 121 rayekwsdts fgmvlqrfay eirrfledvy lktlverler dfnkvpnfsi releqiinet 181 evnkqmelly niyeeifrei eerrtnqssq edfnnfmdsm knesslhlrl mvafdttvyp 241 vpkggailki fqqkilenlg drssvmflkk llnnisqdyc tmlyewltqg ilndpyqefm 301 tyddlegktd nifdtrdraw dtqyfirkdv llrdcdseed knllfkmlrt gillkvvras 361 lqiptipsns sditiqeind fadlmegsnl elyvdkcysr aneiflklff qgydlinvlk 421 hlqqiflgyq sghnvlkflt knmgeltkhy rndnnanydk llqnfelerq senpnnlmrq 481 llmiqfdtet lpqvlshylq iypevpenns anddsdplmh annfknmnai lfdelskert 541 gayhgsnlel ytpksaiyhl kfdinipypl niiisrtcmi kyqiilryql vlqyhsrlld 601 etwmdlnktp swkyrgysht vkrrivratr vlhakmnhfi ktimeyfnqn vidkevysle 661 kcyrnptlav aiqneleggl tnimtnrcls dliplqlqif divykfckfi ksmraklcql 721 dpvlyekhks gmmktlnegy rtnnggqedv gyqedaalel iqklieyisn assifrkcli 781 nftqelstek fdfydsssvd aagiervlys ivpprsasas sqr // LOCUS NP_001257667 112 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR173C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257667 VERSION NP_001257667.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270738.1 REFERENCE 1 (residues 1 to 112) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 112) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 112) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 112) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35091. Method: conceptual translation. FEATURES Location/Qualifiers source 1..112 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..112 /product="uncharacterized protein" /calculated_mol_wt="12746" CDS 1..112 /locus_tag="YHR173C" /coded_by="NM_001270738.1:1..339" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; expressed at both mRNA and protein levels; SWAT-GFP and mCherry fusion proteins localize to the vacuole" /db_xref="GeneID:856578" /db_xref="SGD:S000001216" ORIGIN 1 mlfffiyawc hlshtilqps tkiqmivrsk pesngekklm nhdepndqyn qrnypsevya 61 dlvshfmnfa ygkvhesglq kkgvrcvdvs isgcqfwngi plsaswctsl vt // LOCUS NP_012044 437 aa linear PLN 30-JUN-2025 DEFINITION phosphopyruvate hydratase ENO2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012044 VERSION NP_012044.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179305.1 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 437) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06866. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..437 /product="phosphopyruvate hydratase ENO2" /EC_number="4.2.1.11" /calculated_mol_wt="46783" Region 1..430 /region_name="PTZ00081" /note="enolase; Provisional" /db_xref="CDD:240259" CDS 1..437 /gene="ENO2" /locus_tag="YHR174W" /coded_by="NM_001179305.1:1..1314" /experiment="EXISTENCE:direct assay:GO:0000015 phosphopyruvate hydratase complex [PMID:6282834]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16565073]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009898 cytoplasmic side of plasma membrane [PMID:16544286]" /experiment="EXISTENCE:direct assay:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:16565073]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:mutant phenotype:GO:0004634 phosphopyruvate hydratase activity [PMID:6282834]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:6282834]" /experiment="EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:16565073]" /note="Enolase II, a phosphopyruvate hydratase; catalyzes conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; mRNA is asymmetrically distributed to daughter cells in a Sir2p-dependent manner, and asymmetry is lost during replicative aging; expression induced in response to glucose; ENO2 has a paralog, ENO1, that arose from the whole genome duplication" /db_xref="GeneID:856579" /db_xref="SGD:S000001217" ORIGIN 1 mavskvyars vydsrgnptv evelttekgv frsivpsgas tgvhealemr dedkskwmgk 61 gvmnavnnvn nviaaafvka nldvkdqkav ddfllsldgt anksklgana ilgvsmaaar 121 aaaaeknvpl yqhladlsks ktspyvlpvp flnvlnggsh aggalalqef miaptgaktf 181 aeamrigsev yhnlksltkk rygasagnvg deggvapniq taeealdliv daikaaghdg 241 kvkigldcas seffkdgkyd ldfknpesdk skwltgvela dmyhslmkry pivsiedpfa 301 eddweawshf fktagiqiva ddltvtnpar iataiekkaa dalllkvnqi gtlsesikaa 361 qdsfaanwgv mvshrsgete dtfiadlvvg lrtgqiktga parserlakl nqllrieeel 421 gdkavyagen fhhgdkl // LOCUS NP_012045 189 aa linear PLN 30-JUN-2025 DEFINITION low-affinity Cu transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_012045 VERSION NP_012045.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179306.3 REFERENCE 1 (residues 1 to 189) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 189) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 189) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 189) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06867. On Jul 30, 2012 this sequence version replaced NP_012045.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..189 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..189 /product="low-affinity Cu transporter" /calculated_mol_wt="21520" Region 61..166 /region_name="Ctr" /note="Ctr copper transporter family; pfam04145" /db_xref="CDD:461194" CDS 1..189 /gene="CTR2" /locus_tag="YHR175W" /coded_by="NM_001179306.3:1..570" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11523804]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0005375 copper ion transmembrane transporter activity [PMID:7499355]" /experiment="EXISTENCE:genetic interaction:GO:0015677 copper ion import [PMID:7499355]" /experiment="EXISTENCE:mutant phenotype:GO:0005375 copper ion transmembrane transporter activity [PMID:11523804]" /experiment="EXISTENCE:mutant phenotype:GO:0006825 copper ion transport [PMID:11523804]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:23450501]" /note="Low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation; regulated by nonsense-mediated mRNA decay pathway" /db_xref="GeneID:856580" /db_xref="SGD:S000001218" ORIGIN 1 mddkktwstv tlrtfnqlvt ssligyskkm dsmnhkmegn aghdhsdmhm gdgddtcsmn 61 mlfswsyknt cvvfewwhik tlpglilscl aifglaylye ylkycvhkrq lsqrvllpnr 121 sltkinqadk vsnsilyglq vgfsfmlmlv fmtyngwlml avvcgaiwgn yswctsyspe 181 iddsslach // LOCUS NP_878090 49 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR175W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878090 VERSION NP_878090.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184554.1 REFERENCE 1 (residues 1 to 49) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 49) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 49) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 49) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06868. Method: conceptual translation. FEATURES Location/Qualifiers source 1..49 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..49 /product="uncharacterized protein" /calculated_mol_wt="5579" CDS 1..49 /locus_tag="YHR175W-A" /coded_by="NM_001184554.1:1..150" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466530" /db_xref="SGD:S000028553" ORIGIN 1 minyvnitci ifstrtllvf dtslyippfm lsfigyslsn qnsplflyh // LOCUS NP_012046 432 aa linear PLN 30-JUN-2025 DEFINITION N,N-dimethylaniline monooxygenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012046 VERSION NP_012046.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179307.3 REFERENCE 1 (residues 1 to 432) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 432) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 432) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 432) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06869. On Jul 30, 2012 this sequence version replaced NP_012046.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..432 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..432 /product="N,N-dimethylaniline monooxygenase" /calculated_mol_wt="48968" Region 37..>343 /region_name="FMO-like" /note="Flavin-binding monooxygenase-like; pfam00743" /db_xref="CDD:395602" CDS 1..432 /gene="FMO1" /locus_tag="YHR176W" /coded_by="NM_001179307.3:1..1299" /experiment="EXISTENCE:direct assay:GO:0004499 N,N-dimethylaniline monooxygenase activity [PMID:10600176]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10077572]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:10077572]" /note="Flavin-containing monooxygenase; localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins" /db_xref="GeneID:856581" /db_xref="SGD:S000001219" ORIGIN 1 mtvndkkrla iigggpggla aarvfsqslp nfeieifvkd ydiggvwhyp eqksdgrvmy 61 dhletniskk lmqfsgfpfe envplypsrr niweylkayy ktfiankdai sihfstevty 121 lkkknsqwei tskdelrttk sdfdfvivas ghysvpklpt niagldlwfd nkgafhskdf 181 kncefarekv vivvgngssg qdianqlttv akkvynsike pasnqlkakl ietvqtidsa 241 dwknrsvtls dgrvlqnidy iifatgyyys fpfiepsvrl evlgegvtgd khssvnlhnl 301 wehmiyvkdp tlsfiltpql vipfplselq aaimvevfck slpitttfds nacgthnfpk 361 gkdleyyael qellnsiprr vghfepvvwd drlidlrnss ytdkeernvl laehaqalkk 421 kkapyflpap ht // LOCUS NP_012047 453 aa linear PLN 30-JUN-2025 DEFINITION Rof1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012047 VERSION NP_012047.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179308.1 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 453) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06870. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..453 /product="Rof1p" /calculated_mol_wt="51917" Region 2..249 /region_name="TOS9" /note="Gluconate transport-inducing protein [Signal transduction mechanisms / Carbohydrate transport and metabolism]; COG5037" /db_xref="CDD:227370" CDS 1..453 /gene="ROF1" /locus_tag="YHR177W" /coded_by="NM_001179308.1:1..1362" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:24994900]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:24994900]" /note="Putative transcription factor containing a WOPR domain; binds DNA in vitro; similar to C. albicans Wor1p transcription factor that regulates white-opaque switching; overexpression causes a cell cycle delay or arrest" /db_xref="GeneID:856582" /db_xref="SGD:S000001220" ORIGIN 1 mmdisptcyg yiddeqdlal vfqgvfngnl rcierrpyda ekvelvnpgn ifvfneeksg 61 ikrwtdgfsw spsrisgkfl vyreynrlgs thdlplhnvp eyniferahr kyfytgllkk 121 tfslkfnmdp tdstkletfh liayytekdi hqgslrrpse npffhkfrps qklldalqkv 181 avgngrsnps knnergrtka hnyktrrsls sspsycdlls nynnhpgnip vrtavqlplt 241 tfnnapremh qqqhrqqqqy llpideqnkl plpymqhqpq pigvynpnyq pglrrtvsqp 301 mifcntyntl pqqptaapye rrgvspsviy ssntlspipy qnidpyssrs gpecnhskap 361 iaptmmppvh hilvhdyrqp kpvtdsinpp nvnittsttn knldgiyilp aprmnppaqt 421 qyqmihapds mqhpptfskn ntssnpkshq ysk // LOCUS NP_012048 743 aa linear PLN 30-JUN-2025 DEFINITION Stb5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012048 VERSION NP_012048.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179309.3 REFERENCE 1 (residues 1 to 743) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 743) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 743) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 743) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06871. On Jul 30, 2012 this sequence version replaced NP_012048.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..743 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..743 /product="Stb5p" /calculated_mol_wt="83343" Region 20..58 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(21,26..29,31,34,44) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(22,25,32,39,42,49) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 293..699 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..743 /gene="STB5" /locus_tag="YHR178W" /coded_by="NM_001179309.3:1..2232" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:11943786]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:11943786]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:11943786]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:11943786]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16914749]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:16914749]" /note="Transcription factor; regulates multidrug resistance and the oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro; negative regulator of autophagy, modulating the transcription of genes involved in NADPH production and the pentose phosphate pathway; Stb5p expression is reduced during nitrogen starvation and autophagy induction, while STB5 mRNA levels are significantly increased" /db_xref="GeneID:856583" /db_xref="SGD:S000001221" ORIGIN 1 mdgpnfahqg grsqrttely scarcrklkk kcgkqiptca ncdkngahcs ypgraprrtk 61 keladamlrg eyvpvkrnkk vgksplstks mpnsssplsa ngaitpgfsp yenddahkmk 121 qlkpsdpinl vmgaspnsse gvsslisvlt slndnsnpss hlssnensmi psrslpasvq 181 qssttssfgg yntpspliss hvpanaqavp lqnnnrntsn gdngsnvnhd nnngstntpq 241 lsltpyanns apngkfdsvp vdassiefet msccfkggrt tswvredgsf ksidrslldr 301 fiaayfkhnh rlfpmidkia flndaatitd ferlydnkny pdsfvfkvym imaigcttlq 361 ragmvsqdee clsehlafla mkkfrsviil qdietvrcll llgiysffep kgssswtisg 421 iimrltiglg lnreltakkl ksmsaleaea ryrvfwsayc ferlvctslg risgiddedi 481 tvplpralyv derddlemtk lmislrkmgg riykqvhsvs agrqkltieq kqeiisglrk 541 eldeiysres errklkksqm dqverennst tnvisfhsse iwlamrysql qillyrpsal 601 mpkppidsls tlgefclqaw khtytlykkr llplnwitlf rtlticntil yclcqwsidl 661 ieskieiqqc veilrhfger wifamrcadv fqnisntild islshgkvpn mdqltrelfg 721 asdsyqdild ennvdvswvd klv // LOCUS NP_012049 400 aa linear PLN 30-JUN-2025 DEFINITION NADPH dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012049 VERSION NP_012049.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179310.1 REFERENCE 1 (residues 1 to 400) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 400) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 400) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 400) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06872. Method: conceptual translation. FEATURES Location/Qualifiers source 1..400 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..400 /product="NADPH dehydrogenase" /EC_number="1.6.99.1" /calculated_mol_wt="44880" Region 16..372 /region_name="OYE_like_FMN" /note="Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; cd02933" /db_xref="CDD:239243" Site order(36,38,73,115,244,325,346,348..350) /site_type="other" /note="FMN binding site [chemical binding]" /db_xref="CDD:239243" Site order(36,38,73,115,117,124,192,195,197,244,251,325,346, 348..349) /site_type="active" /db_xref="CDD:239243" Site order(38,117,192,195,197,349) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:239243" Site 197 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:239243" CDS 1..400 /gene="OYE2" /locus_tag="YHR179W" /coded_by="NM_001179310.1:1..1203" /experiment="EXISTENCE:direct assay:GO:0003959 NADPH dehydrogenase activity [PMID:8454584]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17897954]" /note="Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856584" /db_xref="SGD:S000001222" ORIGIN 1 mpfvkdfkpq algdtnlfkp ikignnellh ravippltrm raqhpgnipn rdwaveyyaq 61 raqrpgtlii tegtfpspqs ggydnapgiw seeqikewtk ifkaihenks fawvqlwvlg 121 waafpdtlar dglrydsasd nvymnaeqee kakkannpqh sitkdeikqy vkeyvqaakn 181 siaagadgve ihsangylln qfldphsnnr tdeyggsien rarftlevvd avvdaigpek 241 vglrlspygv fnsmsggaet givaqyayvl gelerrakag krlafvhlve prvtnpflte 301 gegeynggsn kfaysiwkgp iiragnfalh pevvreevkd prtligygrf fisnpdlvdr 361 lekglplnky drdtfykmsa egyidyptye ealklgwdkn // LOCUS NP_001335743 163 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR180W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335743 VERSION NP_001335743.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348842.1 REFERENCE 1 (residues 1 to 163) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 163) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 163) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 163) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80263. Method: conceptual translation. FEATURES Location/Qualifiers source 1..163 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..163 /product="uncharacterized protein" /calculated_mol_wt="18007" CDS 1..163 /locus_tag="YHR180W" /coded_by="NM_001348842.1:1..492" /note="hypothetical protein; conserved among S. cerevisiae strains" /db_xref="GeneID:856585" /db_xref="SGD:S000001223" ORIGIN 1 memhwitlva fiatffnlaa tsinnsslpd vdltnplrff tnipaglnfn eviflerngf 61 ylggidspsi yhlingtavy fgdvrdnimp gtvgttrnvt dvdygsllte ygyeantdyv 121 srwiathvvi splnateffq tpvpvpvpvp itilhqqvns klh // LOCUS NP_012051 228 aa linear PLN 30-JUN-2025 DEFINITION Svp26p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012051 VERSION NP_012051.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179312.3 REFERENCE 1 (residues 1 to 228) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 228) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 228) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 228) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06873. On Jul 30, 2012 this sequence version replaced NP_012051.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..228 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..228 /product="Svp26p" /calculated_mol_wt="26153" Region 2..205 /region_name="Erv26" /note="Transmembrane adaptor Erv26; pfam04148" /db_xref="CDD:461197" CDS 1..228 /gene="SVP26" /locus_tag="YHR181W" /gene_synonym="ERV26" /coded_by="NM_001179312.3:1..687" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:16957051]" /experiment="EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:16957051]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:16957051]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:30842360|PMID:16957051]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:16107716]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:16107716]" /experiment="EXISTENCE:mutant phenotype:GO:0090110 COPII-coated vesicle cargo loading [PMID:30842360]" /experiment="EXISTENCE:mutant phenotype:GO:0097020 COPII receptor activity [PMID:20236934]" /experiment="EXISTENCE:physical interaction:GO:0097020 COPII receptor activity [PMID:20236934]" /note="ER exit adaptor for Golgi mannosyltransferases; facilitates the exit of Kre2p, Ktr1p and Mnn4p from the ER; involved in COPII-coated vesicle cargo loading and transport; may also promote the retention of proteins in the early Golgi compartment; integral membrane protein of early Golgi and ER" /db_xref="GeneID:856587" /db_xref="SGD:S000001224" ORIGIN 1 mllelisyag tvsgflfltl siasglyyis elveehtept rrfltraiyg iililillll 61 ldgfpfkltl fsiacyivyy qnlksfpfis ltsptfllsc vcvvlnhyfw fkyfndtevp 121 pqfkfdpnyi prrrasfaev asffgicvwf ipfalfvsls agdyvlptts eqhmakkndd 181 ittnnqpkfr kravglarvv insvrkyiys larvfgyeie pdfdrlav // LOCUS NP_012052 785 aa linear PLN 30-JUN-2025 DEFINITION Rgd3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012052 VERSION NP_012052.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179313.1 REFERENCE 1 (residues 1 to 785) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 785) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 785) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 785) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06874. Method: conceptual translation. FEATURES Location/Qualifiers source 1..785 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..785 /product="Rgd3p" /calculated_mol_wt="89978" Region 492..>646 /region_name="RhoGAP" /note="GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to...; cl02570" /db_xref="CDD:470621" CDS 1..785 /gene="RGD3" /locus_tag="YHR182W" /coded_by="NM_001179313.1:1..2358" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:32941095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:32941095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030659 cytoplasmic vesicle membrane [PMID:32941095]" /experiment="EXISTENCE:direct assay:GO:0043547 positive regulation of GTPase activity [PMID:32941095]" /experiment="EXISTENCE:mutant phenotype:GO:0007163 establishment or maintenance of cell polarity [PMID:32941095]" /note="GTPase activating protein (GAP) for Rho3p, involved in cell polarity green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm; relocalizes from bud neck to cytoplasm upon DNA replication stress" /db_xref="GeneID:856588" /db_xref="SGD:S000001225" ORIGIN 1 msvkehneed iigdelqnsr qlsidcdsvk islrntywtk dyttgiklfi khmkrendll 61 ikdikfyndf vnkfwkptln nlqkmeatns mnsrllevms kqfniisteq verdckiplq 121 elrdlnesfl reaendlssr ysayikdlva akealigcek rvqsiyklkk antpvensss 181 vfdngkdsap ltrlnfvcef pytlderlkf edcdqfmsfl qtlkgkvile ksvfsvpgls 241 nqsfqgrsli kelkkleprl nlslfnidri gnefiqlgii qeyslsfyss kvsqfdqeky 301 yywnsevlat qesngnagnr kkksygelth sdneheeksn vssiktsisd wirkvsqhdn 361 ddcdaagstd mnknewkslk qqlessqdif fskccqleys kvqlektiyd ycknyskmed 421 gikralessn mmfqqkcekf tdspvcslqe aqlpqetana dvrgfflrdn gipfrrwnil 481 easdpvdack eisiksekff cgseinnela aldtlgaiki ilrqiekepn ankviqswhr 541 didfvrvsnl krdllgefkg skttentnsi itahffensh syvtndlvgl iklwllelpd 601 slipsnhydd likaekslts lceqfptssl rflqelanhf qlinskyslp pqtiqdlfrd 661 nsdidiplah hfvrrtglqn pidikilspt lstffinert vetlqtlian rittattatl 721 tepptiiikd ttapihstpk pppndkdghf iprpfktsst pttperpkrk sglflpinvn 781 dvpst // LOCUS NP_012053 489 aa linear PLN 30-JUN-2025 DEFINITION phosphogluconate dehydrogenase (decarboxylating) GND1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012053 VERSION NP_012053.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179314.3 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 489) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06875. On Jul 30, 2012 this sequence version replaced NP_012053.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..489 /product="phosphogluconate dehydrogenase (decarboxylating) GND1" /EC_number="1.1.1.44" /calculated_mol_wt="53412" Region 4..477 /region_name="gnd" /note="6-phosphogluconate dehydrogenase (decarboxylating); TIGR00873" /db_xref="CDD:273314" CDS 1..489 /gene="GND1" /locus_tag="YHR183W" /coded_by="NM_001179314.3:1..1470" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity [PMID:1328471]" /experiment="EXISTENCE:mutant phenotype:GO:0009051 pentose-phosphate shunt, oxidative branch [PMID:1328471]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:9480895]" /note="6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress; GND1 has a paralog, GND2, that arose from the whole genome duplication" /db_xref="GeneID:856589" /db_xref="SGD:S000001226" ORIGIN 1 msadfgligl avmgqnliln aadhgftvca ynrtqskvdh flaneakgks iigatsiedf 61 isklkrprkv mllvkagapv dalinqivpl lekgdiiidg gnshfpdsnr ryeelkkkgi 121 lfvgsgvsgg eegarygpsl mpggseeawp hiknifqsis aksdgepcce wvgpagaghy 181 vkmvhngiey gdmqliceay dimkrlggft dkeisdvfak wnngvldsfl veitrdilkf 241 ddvdgkplve kimdtagqkg tgkwtainal dlgmpvtlig eavfarclsa lknerirask 301 vlpgpevpkd avkdreqfvd dleqalyask iisyaqgfml ireaaatygw klnnpaialm 361 wrggciirsv flgqitkayr eepdlenllf nkffadavtk aqsgwrksia lattygiptp 421 afstalsfyd gyrserlpan llqaqrdyfg ahtfrvlpec asdnlpvdkd ihinwtghgg 481 nvssstyqa // LOCUS NP_012054 571 aa linear PLN 30-JUN-2025 DEFINITION Ssp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012054 VERSION NP_012054.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179315.1 REFERENCE 1 (residues 1 to 571) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 571) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 571) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 571) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06876. Method: conceptual translation. FEATURES Location/Qualifiers source 1..571 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..571 /product="Ssp1p" /calculated_mol_wt="65685" CDS 1..571 /gene="SSP1" /locus_tag="YHR184W" /gene_synonym="SPO3" /coded_by="NM_001179315.1:1..1716" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:11742972]" /experiment="EXISTENCE:direct assay:GO:0070056 prospore membrane leading edge [PMID:24390141|PMID:11742972]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:11742972]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:11742972]" /note="Protein involved in the control of meiotic nuclear division; involved in the coordination of meiosis with spore formation; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; required for assembly of the leading edge coat and both prospore membrane shaping and organization; transcription is induced midway through meiosis" /db_xref="GeneID:856590" /db_xref="SGD:S000001227" ORIGIN 1 mrssgtyend psgeitstsp kqskqkkptk frermrrwlq ngknnnhqge edvpeifnkn 61 fypqtgmtaf nnndngevqd vtnnfflpse desgpvqssv ktfltgnnde dsnfqqnqnp 121 kqkselpksp yrqkptqeia llkdlfvtnk yddpylnsst rfgnitstfp sslslrtvtl 181 qtikkridci sakkkevwkt eekflkdilm wlqssnfedp dtisliheie kifeedihfe 241 qnvsdclkei snnfeyicmr etqlinegni lkndlkkyak arehkgekhe dtevlrekvi 301 ssqksfdvtk rhykhaisit trqlfmnlaf eyyencsdmk disrkylqes lstlqtidtl 361 sfseelekir krrfdkfwak tnpdptnniq kfvnmrtgva gfndslmnhl ygklsfgvap 421 veeelqnsqp ehtdvpenvw nevlsdynsm dgnpitsnkf lsakelepdq lvellaqeke 481 ekeaknisss taevpsisqp eikkenlesn dslilrstkr nvnvnaaslr nlsikktqvk 541 pesaseeskv laaalndakq nldenvwrtp i // LOCUS NP_012055 237 aa linear PLN 30-JUN-2025 DEFINITION Pfs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012055 VERSION NP_012055.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179316.3 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 237) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06877. On Jul 30, 2012 this sequence version replaced NP_012055.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..237 /product="Pfs1p" /calculated_mol_wt="27753" CDS 1..237 /gene="PFS1" /locus_tag="YHR185C" /gene_synonym="ADY1" /coded_by="NM_001179316.3:1..714" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:11553705]" /note="Sporulation protein required for prospore membrane formation; required for prospore membrane formation at selected spindle poles; ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation" /db_xref="GeneID:856591" /db_xref="SGD:S000001228" ORIGIN 1 mnqgytqlsa pelketktsk lnkmnnfrss piaeiinkip pdcgkiqntt fpefnpalrr 61 rqheqwpaye kpirvtdsms pqlssinclp nlyphgtlpl pnpylsylnh iekvncqdvk 121 fsnwsvlhns nngfeiptyf sprttqnmpc sekveswler lpifvgfdgy lftncfdyey 181 mldweeteft fektscmetd yskaltdtdi iyiqekkiea lirnqylkey efsqkdf // LOCUS NP_012056 1557 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-binding TORC1 subunit KOG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012056 VERSION NP_012056.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179317.1 REFERENCE 1 (residues 1 to 1557) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1557) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1557) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1557) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06878. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1557 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1557 /product="ubiquitin-binding TORC1 subunit KOG1" /calculated_mol_wt="177479" Region 80..232 /region_name="Raptor_N" /note="Raptor N-terminal CASPase like domain; pfam14538" /db_xref="CDD:464202" Region 738..769 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 781..807 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 783..812 /region_name="HEAT" /note="HEAT repeat; pfam02985" /db_xref="CDD:460773" Region 1224..1548 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(1226,1230,1236..1237,1249..1250,1273,1277,1283,1288, 1300..1301,1325,1330,1336..1337,1350,1370,1374,1380,1385, 1397..1398,1420,1424,1430..1431,1443..1444,1472,1477,1481, 1494..1495,1536,1541,1547..1548) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 1258..1296 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1301..1348 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1356..1398 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1405..1442 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1461..1517 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1522..1547 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..1557 /gene="KOG1" /locus_tag="YHR186C" /gene_synonym="LAS24" /coded_by="NM_001179317.1:1..4674" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:16394584|PMID:14562095|PMID:26928762|PMID:17560372]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16394584]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:12408816]" /note="Ubiquitin-binding protein; centrally regulates metabolic homeostasis and carbon utilization during nutrient limitation by managing Snf1p activity; subunit of TORC1 rapamycin-sensitive complex involved in growth control; central scaffold that holds the different components of TORC1 together; contains four HEAT repeats and seven WD-40 repeats" /db_xref="GeneID:856593" /db_xref="SGD:S000001229" ORIGIN 1 mpeiygpqpl kplntvmrhg feeqyqsdql lqslandfif yfddkrhktn gnpipeedkq 61 rdvnryyqpi tdwkimkdrq ktvsaalllc lnlgvdppdv mkthpcarve awvdplnfqd 121 skkaieqigk nlqaqyetls lrtrykqsld pcvedvkrfc nslrrtsked rilfhynghg 181 vpkptksgei wvfnrgytqy ipvslydlqt wlgapcifvy dcnsaenili nfqkfvqkri 241 kddeegnhdv aapsptsayq dcfqlascts delllmspel padlfscclt cpieisirif 301 lmqsplkdsk ykiffensts nqpfgdskns fkskipnvni pgmlsdrrtp lgelnwifta 361 itdtiawtsl prplfkklfr hdlmiaalfr nfllakrimp wynchpvsdp elpdsitthp 421 mwkswdlamd evltkividl knappatale sqmilqqqet lqnggssksn aqdtkagsiq 481 tqsrfavanl stmslvnnpa lqsrksislq ssqqqlqqqq qqqqqftgff eqnltafelw 541 lkyasnvrhp peqlpivlqv llsqvhrira lvllsrfldl gpwavylsls igifpyvlkl 601 lqspapelkp ilvfiwarim sidykntqse likekgymyf vtvlvpdwgv ngmsatngsa 661 minsgnpltm tasqningps sryyerqqgn rtsnlghnnl pfyhsndttd eqkamavfvl 721 asfvrnfplg qkncfslelv nklcfyidns eipllrqwcv illgllfadn plnrfvcmnt 781 gaveillksl kdpvpevrta sifalkhfis gfqdaevilr lqqefeeqyq qlhsqlqhlq 841 nqshlqqqqs qqqqqhleqq qmkiekqirh cqvmqnqlev idlrklkrqe ignlisilpl 901 indgsslvrk elvvyfshiv srysnffivv vfndlleeik lleksdintr ntsdkysvsq 961 gsifytvwks llilaedpfl enkelskqvi dyillelsah kelggpfavm ekfllkrssk 1021 ahqtgkfgfn ssqvqfvkss lrsfspnerv dnnafkkeqq qhdpkishpm rtslaklfqs 1081 lgfsesnsds dtqssntsmk shtskkgpsg lyllngnnni yptaetprfr khteplqlpl 1141 nssfldysre yfqepqmkkq eadepgsvey narlwrrnrn etiiqetqge kklsiygnws 1201 kklislnnks qpklmkfaqf edqlitaddr stitvfdwek gktlskfsng tpfgtkvtdl 1261 klineddsal lltgssdgvi kiyrdyqdvd tfkivsawrg ltdmlltprs tglltewlqi 1321 rgsllttgdv kvirvwdaht etvevdipak tsslitslta dqlagnifva gfadgslrvy 1381 drrldprdsm irrwragndk qgvwinnvhl qrggyrelvs gatngvvelw dirsedpves 1441 fvdqnvtsqy gsqqkpttmt cmqvhehapi iatgtkqiki wttsgdllns fknshnngvt 1501 stlaatgipk slsysstsda flssmafhph rmmiaatnsh dsivniykce deridyf // LOCUS NP_012057 309 aa linear PLN 30-JUN-2025 DEFINITION Elongator subunit IKI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012057 VERSION NP_012057.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179318.3 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 309) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06879. On Jul 30, 2012 this sequence version replaced NP_012057.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..309 /product="Elongator subunit IKI1" /calculated_mol_wt="35089" Region 11..290 /region_name="Elong_Iki1" /note="Elongator subunit Iki1; pfam10483" /db_xref="CDD:431307" CDS 1..309 /gene="IKI1" /locus_tag="YHR187W" /gene_synonym="ELP5; HAP2; TOT5" /coded_by="NM_001179318.3:1..930" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:22343726]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:22343726]" /experiment="EXISTENCE:direct assay:GO:0033588 elongator holoenzyme complex [PMID:11689709]" /experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:15769872]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:22343726]" /note="Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin; localizes to cytosol, nucleus and peroxisomes" /db_xref="GeneID:856594" /db_xref="SGD:S000001230" ORIGIN 1 massshnpvi llkrilslte sspfilclds iaqtsykliq efvhqskskg neypivyisf 61 etvnkpsyct qfidatqmdf vhlvkqiisy lpaatatqak khmviidsln yisteyitrf 121 lseiasphct mvatyhkdik denrtvipdw nnnypdkltl lqfmattivd idvvltgtld 181 teevsellne friprglnnd ifqlrlvnkr ksgrsleydf ivnsntheye llsttkqeee 241 sssngletpe mlqglttfnl gtsnkqklak dqvalpflea qsfgqggaiv yeyekdddyd 301 eedpyedpf // LOCUS NP_012058 610 aa linear PLN 30-JUN-2025 DEFINITION GPI-anchor transamidase subunit GPI16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012058 VERSION NP_012058.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179319.1 REFERENCE 1 (residues 1 to 610) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 610) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 610) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 610) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06880. Method: conceptual translation. FEATURES Location/Qualifiers source 1..610 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..610 /product="GPI-anchor transamidase subunit GPI16" /calculated_mol_wt="68641" Region 35..588 /region_name="Gpi16" /note="Gpi16 subunit, GPI transamidase component; pfam04113" /db_xref="CDD:461180" CDS 1..610 /gene="GPI16" /locus_tag="YHR188C" /coded_by="NM_001179319.1:1..1833" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11598210]" /experiment="EXISTENCE:direct assay:GO:0042765 GPI-anchor transamidase complex [PMID:11598210]" /experiment="EXISTENCE:mutant phenotype:GO:0016255 attachment of GPI anchor to protein [PMID:11598210]" /note="Subunit of the glycosylphosphatidylinositol transamidase complex; involved in the addition of GPIs to newly synthesized proteins; luminally-oriented, type I integral membrane glycoprotein of the ER; human PIG-T homolog" /db_xref="GeneID:856595" /db_xref="SGD:S000001231" ORIGIN 1 miltlayfml gtlllgvfae dtvsqigind slwypydeal vlkplpnndl llsfafqlqs 61 epfdpavssm sydayehytt fpraipplle statrqfhlr ftrgfwdals wgqlphagke 121 agasgvelws qvqamdqeqa fhnwkklsns lsglfcssln fidesrttfp rrsyasdiga 181 plfnstekly lmraslpnep ictenltpfi kllptrgksg ltslldghkl fdslwnsisl 241 diaticsede dalchyemda riemvthvps alargerpip kpldgntlrc dtdkpfdsyq 301 cfplpepsqt hfklsqlfar pinngnlfan rptricaevd rstwtaflsv ddtifsthdn 361 cfdlsndqne ggsgydfile stdttkvtpi vpvpihvsrs ltgngqdrgg mrivfhndnd 421 tpvkliyfes lpwfmrvyls slqitsttsp qlqendiild kyylqaadrk rpghleftml 481 ipantdivmt yqfdkallqf aeyppdanhg feidaavitv lslessssly emrtstllls 541 lstpdfsmpy nviiltstim glifgmlynl mvkrmvtvee adkitlqsgl kykllklkek 601 flgkkktktd // LOCUS NP_012059 190 aa linear PLN 30-JUN-2025 DEFINITION aminoacyl-tRNA hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012059 VERSION NP_012059.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179320.3 REFERENCE 1 (residues 1 to 190) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 190) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 190) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 190) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06881. On Jul 30, 2012 this sequence version replaced NP_012059.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..190 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..190 /product="aminoacyl-tRNA hydrolase" /EC_number="3.1.1.29" /calculated_mol_wt="20905" Region 6..190 /region_name="pth" /note="aminoacyl-tRNA hydrolase; TIGR00447" /db_xref="CDD:213531" Site order(14,24,72..73,99,120) /site_type="active" /note="putative active site [active]" /db_xref="CDD:238259" Site 24 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:238259" CDS 1..190 /gene="PTH1" /locus_tag="YHR189W" /coded_by="NM_001179320.3:1..573" /experiment="EXISTENCE:direct assay:GO:0004045 peptidyl-tRNA hydrolase activity [PMID:12799450]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14562095|PMID:14576278]" /experiment="EXISTENCE:genetic interaction:GO:0004045 peptidyl-tRNA hydrolase activity [PMID:12475929]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:12799450]" /note="One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2" /db_xref="GeneID:856596" /db_xref="SGD:S000001232" ORIGIN 1 msgkwrlvlt gignpepqya gtrhnvglym lellrkrlgl qgrtyspvpn tggkvhyied 61 ehctilrsdg qymnlsgeqv ckvwaryaky qarhvvihde lsvacgkvql rapstsirgh 121 nglrsllkcs ggrvpfakla igigrepgsr srdpasvsrw vlgaltpqel qtlltqsepa 181 awraltqyis // LOCUS NP_012060 444 aa linear PLN 30-JUN-2025 DEFINITION bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012060 VERSION NP_012060.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179321.1 REFERENCE 1 (residues 1 to 444) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 444) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 444) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 444) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06882. Method: conceptual translation. FEATURES Location/Qualifiers source 1..444 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..444 /product="bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase" /EC_number="2.5.1.21" /calculated_mol_wt="51589" Region 37..377 /region_name="squal_synth" /note="farnesyl-diphosphate farnesyltransferase; TIGR01559" /db_xref="CDD:188157" Site order(49..53,322..325) /site_type="active" /note="active site lid residues [active]" /db_xref="CDD:173831" Site order(51,53,72,76,79,83,178,183,187,215,218,225..226, 229..230,235,295..296) /site_type="other" /note="substrate binding pocket [chemical binding]" /db_xref="CDD:173831" Site order(53,72,79,83,178,186,190,218,225..226,230,235, 295..296,300) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:173831" Site order(79..83,226..230) /site_type="active" /note="substrate-Mg2+ binding site [active]" /db_xref="CDD:173831" Site 79..83 /site_type="other" /note="aspartate-rich region 1" /db_xref="CDD:173831" Site 226..230 /site_type="other" /note="aspartate-rich region 2" /db_xref="CDD:173831" CDS 1..444 /gene="ERG9" /locus_tag="YHR190W" /coded_by="NM_001179321.1:1..1335" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:1807826|PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:8323279]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:350878]" /experiment="EXISTENCE:direct assay:GO:0051996 squalene synthase [NAD(P)H] activity [PMID:8323279|PMID:8157649]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:1807826|PMID:200835]" /note="Farnesyl-diphosphate farnesyl transferase (squalene synthase); joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway" /db_xref="GeneID:856597" /db_xref="SGD:S000001233" ORIGIN 1 mgkllqlalh pvemkaalkl kfcrtplfsi ydqstspyll hcfellnlts rsfaavirel 61 hpelrncvtl fylilraldt ieddmsiehd lkidllrhfh ekllltkwsf dgnapdvkdr 121 avltdfesil iefhklkpey qevikeitek mgngmadyil denynlnglq tvhdydvych 181 yvaglvgdgl trliviakfa neslysneql yesmglflqk tniirdyned lvdgrsfwpk 241 eiwsqyapql kdfmkpeneq lgldcinhlv lnalshvidv ltylagiheq stfqfcaipq 301 vmaiatlalv fnnrevlhgn vkirkgttcy lilksrtlrg cveifdyylr diksklavqd 361 pnflklniqi skieqfmeem yqdklppnvk pnetpiflkv kersryddel vptqqeeeyk 421 fnmvlsiils vllgfyyiyt lhra // LOCUS NP_012061 133 aa linear PLN 30-JUN-2025 DEFINITION Ctf8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012061 VERSION NP_012061.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179322.3 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 133) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06883. On Jul 30, 2012 this sequence version replaced NP_012061.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..133 /product="Ctf8p" /calculated_mol_wt="15038" Region 29..132 /region_name="Ctf8" /note="pfam09696" /db_xref="CDD:430758" CDS 1..133 /gene="CTF8" /locus_tag="YHR191C" /coded_by="NM_001179322.3:1..402" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:11389843|PMID:17483413]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:11389843]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16525505]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:21347277]" /experiment="EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]" /note="Subunit of a complex with Ctf18p; shares some subunits with Replication Factor C; required for sister chromatid cohesion" /db_xref="GeneID:856598" /db_xref="SGD:S000001234" ORIGIN 1 mpsvdidasq wqkltqsrek qttvitplgm mmleiqgele lpkdfaslar rdspnegrfs 61 eqdgetlirf gslqidgera tlfvgkkqrl lgkvtkldvp mgimhfnskd nkvelvdvmk 121 ykvifkdrpl pim // LOCUS NP_012062 278 aa linear PLN 30-JUN-2025 DEFINITION Lnp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012062 VERSION NP_012062.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179323.1 REFERENCE 1 (residues 1 to 278) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 278) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 278) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 278) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06884. Method: conceptual translation. FEATURES Location/Qualifiers source 1..278 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..278 /product="Lnp1p" /calculated_mol_wt="31932" Region 10..278 /region_name="COG5415" /note="Predicted integral membrane metal-binding protein [General function prediction only]" /db_xref="CDD:227702" CDS 1..278 /gene="LNP1" /locus_tag="YHR192W" /coded_by="NM_001179323.1:1..837" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071782 endoplasmic reticulum tubular network [PMID:22729086]" /experiment="EXISTENCE:genetic interaction:GO:0034976 response to endoplasmic reticulum stress [PMID:27117666]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:29915089]" /experiment="EXISTENCE:mutant phenotype:GO:0071786 endoplasmic reticulum tubular network organization [PMID:22729086]" /note="Lunapark family member involved in ER network formation; regulates the ER asymmetry-induced inheritance block during ER stress; localizes to ER junctions and this localization is regulated by the yeast atlastin ortholog Sey1p; required for reticulophagy where it is proposed to stabilize the actin-dependent remodeling of the ER; interacts with the reticulon protein Rtn1p; induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:856599" /db_xref="SGD:S000001235" ORIGIN 1 mfsalgkwvr gsrndkdfvt kytadlsqit sqihqldval kksqsilsqw qsnltfygia 61 ltvlalsyty weyhgyrpyl vvtallcigs lilfkwaltk lyafynnnrl rklaklraih 121 qkkleklkee thynatssii qrfssgedqn ddamvlldde lnakyqelnn lktelekfkk 181 eshvkglkke dsdawfdkii svlaggneld stsslspfkk iicpqchwks ncyrlaskpi 241 ificphcnhk idevkereda ieakqpaqps qsekektk // LOCUS NP_012063 174 aa linear PLN 30-JUN-2025 DEFINITION Egd2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012063 VERSION NP_012063.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179324.3 REFERENCE 1 (residues 1 to 174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 174) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06885. On Jul 30, 2012 this sequence version replaced NP_012063.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..174 /product="Egd2p" /calculated_mol_wt="18578" Region 28..74 /region_name="NAC_NACA" /note="nascent polypeptide-associated complex (NAC), alpha subunit; cd22054" /db_xref="CDD:409233" Site order(32,34..44,55,62,63..69,74) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:409233" Region 137..173 /region_name="UBA_NAC_like" /note="UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and similar proteins; cd14278" /db_xref="CDD:270464" CDS 1..174 /gene="EGD2" /locus_tag="YHR193C" /coded_by="NM_001179324.3:1..525" /experiment="EXISTENCE:direct assay:GO:0005854 nascent polypeptide-associated complex [PMID:10219998]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:16343487]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:16343487]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:16343487]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:16343487]" /experiment="EXISTENCE:genetic interaction:GO:0006613 cotranslational protein targeting to membrane [PMID:10518932]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:9482879]" /note="Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes" /db_xref="GeneID:856600" /db_xref="SGD:S000001236" ORIGIN 1 msaipenanv tvlnknekka religklglk qipgiirvtf rkkdnqiyai ekpevfrsag 61 gnyvvfgeak vdnftqklaa aqqqaqasgi mpsnedvatk spediqadmq aaaegsvnaa 121 aeeddeegev dagdlnkddi elvvqqtnvs knqaikalka hngdlvnaim slsk // LOCUS NP_012064 579 aa linear PLN 30-JUN-2025 DEFINITION Mdm31p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012064 VERSION NP_012064.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179325.1 REFERENCE 1 (residues 1 to 579) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 579) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 579) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 579) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06886. Method: conceptual translation. FEATURES Location/Qualifiers source 1..579 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..579 /product="Mdm31p" /calculated_mol_wt="66572" Region 74..575 /region_name="MDM31_MDM32" /note="Yeast mitochondrial distribution and morphology (MDM) proteins; pfam08118" /db_xref="CDD:429828" CDS 1..579 /gene="MDM31" /locus_tag="YHR194W" /coded_by="NM_001179325.1:1..1740" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15631992]" /experiment="EXISTENCE:genetic interaction:GO:1900208 regulation of cardiolipin metabolic process [PMID:22403410]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:15631992]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:16020778]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266|PMID:16020778]" /note="Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34" /db_xref="GeneID:856601" /db_xref="SGD:S000001237" ORIGIN 1 mslftrpflr sprqfsvary vywarspalr snlripsiaa aslraysnes ktgrdappdk 61 kskklsnlky iterdsllvq tnniftklki nirwflkkst rpfnsddisa fiswilvsni 121 fififwtttf vslilylint vfaqeylask igkfitknes lsivfesaiv pdwssgkisf 181 qkvfvsrrpk vsrgftkgsq qdalqrakla lserilvnqq dfdngnytqf dltidqvdis 241 lnfrkwingk gildevting lrgvidrthv vwkkdddpkn ylnvyqpgdf eiskftmndv 301 lctlyqpngf rpfqvsifnc dlpqlrkhwl fydilnanni ngtydnsmft ihkkfrtddq 361 hqdptllwkq mtrfrvdnld idhlnagieg pfgwinegrv nmigdvllpd ddaasdslql 421 teilteigdr likkakryts slplvgpgfs pavdeidpnd yfimdfslrl ynvkaevplf 481 tsgltyinsa lirpivgyin shrtyipikc rivkkksdfe gswtiydsyl mrdlsaeayd 541 afadyvadde krtlrlrrvg fwslqlilqv ilmslgaia // LOCUS NP_012065 321 aa linear PLN 30-JUN-2025 DEFINITION Nvj1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012065 VERSION NP_012065.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179326.3 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 321) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06887. On Jul 30, 2012 this sequence version replaced NP_012065.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..321 /product="Nvj1p" /calculated_mol_wt="36290" CDS 1..321 /gene="NVJ1" /locus_tag="YHR195W" /gene_synonym="VAB36" /coded_by="NM_001179326.3:1..966" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:28533415]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:10888680]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:10888680]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:10888680]" /experiment="EXISTENCE:direct assay:GO:0071562 nucleus-vacuole junction assembly [PMID:10888680]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:16912077]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:12529432]" /experiment="EXISTENCE:mutant phenotype:GO:0071562 nucleus-vacuole junction assembly [PMID:10888680]" /note="Nuclear envelope protein; anchored to nuclear inner membrane, interacts with vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN); targeted to vacuole via AP-3 pathway" /db_xref="GeneID:856602" /db_xref="SGD:S000001238" ORIGIN 1 mtrpplvrgi fslglsvavl kgvektvrkh lerqgwiepq kvdyelifti drlknlvdnk 61 realtaeqpd agelswrkvf nfisrqssel dtriyvlill lsfllpiawt vldgdrettl 121 edkdndcnvd lienerrlkh yndgeravlq fgknrsepii lsykdmnvle geheftskee 181 hsnshltsks enalnqvgse dllgchlekq leedknepng eadgeddnnr ekdcssssev 241 esqskcrkes taepdslsrd trttsslkss tsfpisfkgs idlkslnqps sllhiqvspt 301 kssnldaqvn teqaysqpfr y // LOCUS NP_012066 575 aa linear PLN 30-JUN-2025 DEFINITION Utp9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012066 VERSION NP_012066.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179327.1 REFERENCE 1 (residues 1 to 575) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 575) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 575) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 575) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06888. Method: conceptual translation. FEATURES Location/Qualifiers source 1..575 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..575 /product="Utp9p" /calculated_mol_wt="65141" CDS 1..575 /gene="UTP9" /locus_tag="YHR196W" /coded_by="NM_001179327.1:1..1728" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:19812255]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11914276|PMID:12150911|PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:15489292]" /experiment="EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0071528 tRNA re-export from nucleus [PMID:19812255]" /note="Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" /db_xref="GeneID:856603" /db_xref="SGD:S000001239" ORIGIN 1 mgssldlvas fshdstrfaf qasvaqknnv diyplnetkd yvvnsslvsh idyetndmkv 61 sdviffgwcs dlidtqssni krkldedegt gesseqrcen ffvngfpdgr ivvyssngkd 121 ivniiknkke ilgadtdesd iwildsdkvv kklqynnskp lktftlvdgk ddeivhfqil 181 hqngtllvci itkqmvyivd pskrrpstky sfeisdavac efssdgkyll ianneeliay 241 dlkedskliq swpvqvktlk tlddlimalt tdgkinnyki geadkvcsiv vnedleiidf 301 tpinskqqvl iswlnvnepn fesislkeie tqgyitinkn eknnadeadq kkleekeeea 361 qpevqhekke tetkinkkvs ksdqveiani lsshleanst eilddlmsgs wtepeikkfi 421 ltkintvdhl skifltisks itqnpwneen llplwlkwll tlksgelnsi kdkhtkknck 481 hlksalrsse eilpvllgiq grlemlrrqa klredlaqls mqegeddeie viehsnvisn 541 plqdqaspve klepdsivya ngesdefvda seykd // LOCUS NP_012067 763 aa linear PLN 30-JUN-2025 DEFINITION Rix1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012067 VERSION NP_012067.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179328.4 REFERENCE 1 (residues 1 to 763) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 763) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 763) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 763) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06889. On Jul 30, 2012 this sequence version replaced NP_012067.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..763 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..763 /product="Rix1p" /calculated_mol_wt="86608" Region 8..201 /region_name="RIX1" /note="rRNA processing/ribosome biogenesis; pfam08167" /db_xref="CDD:429855" CDS 1..763 /gene="RIX1" /locus_tag="YHR197W" /gene_synonym="IPI2" /coded_by="NM_001179328.4:1..2292" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:22421151]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15528184|PMID:12374754]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0120330 rixosome complex [PMID:14759368]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15528184]" /experiment="EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:22421151]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:14759368]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:22421151]" /note="Component of the Rix1 complex and possibly pre-replicative complexes; required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-replicative complex (pre-RC) formation and maintenance during DNA replication licensing; relocalizes to the cytosol in response to hypoxia; essential gene" /db_xref="GeneID:856604" /db_xref="SGD:S000001240" ORIGIN 1 mseefiavst larnleiakg nefhtilatl rspvyineql lkselsflvt kilklirsgn 61 dfdlwkgcht svvtcaynpl vlsthggqll aaiysrleqk tgfyssviss shgkqlfntl 121 issvaiiidl mknkptlsre alvpklkaii ptlitlsqye pelvlpvlqr ilkrntttfk 181 pftnkfrtvl inliisdyas lgtktqrlvc enfaylhllk iqvsdtsdde tqahhkiyad 241 snwrtglmsi lsqfkpiiql cgeildfeqd nelykliksl pvidesnnke eflpslkldf 301 napltlweip qrlslladml vafislptpf pirvplggin slcevllgvs nkylplkkel 361 rhdnelngvi ntilpqiqfq girlweimvs kygkcglsff egilssielf iplkkksnne 421 idfnvvgslk fefatvfrlv nmilshlghq lniisvisql ievalflshd ktlidslfkn 481 rksimkqqtk tkqskrsksa egafsdiyth pelfvcknsm nwfneindff italnnwilp 541 stphiqilky sitqslrlke rfgyipesfv nllrcevlhp gservsilpi aisllknind 601 dmfellchpk vpvgmvyqlh kpldlgedge vrddinkkev etnesssnan tgletlkale 661 nlenvtipep khevpkvvdd taifkkrsve evierestss hkkvkfveet tvdngeeliv 721 kkavsqtkee ekpmedsede eqeefeipai elsddeeeee eee // LOCUS NP_012068 321 aa linear PLN 30-JUN-2025 DEFINITION Aim18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012068 VERSION NP_012068.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179329.1 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 321) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06890. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..321 /product="Aim18p" /calculated_mol_wt="36371" Region 113..314 /region_name="Chalcone_2" /note="Chalcone isomerase like; pfam16035" /db_xref="CDD:435089" CDS 1..321 /gene="AIM18" /locus_tag="YHR198C" /gene_synonym="FMP22" /coded_by="NM_001179329.1:1..966" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14562095|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:36739946]" /experiment="EXISTENCE:direct assay:GO:0020037 heme binding [PMID:36739946]" /experiment="EXISTENCE:mutant phenotype:GO:0020037 heme binding [PMID:36739946]" /note="Hemoprotein; hypothetical protein that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity" /db_xref="GeneID:856605" /db_xref="SGD:S000001241" ORIGIN 1 mdrgrcanml kslqrtlakc qkspstnhwq cfkrnftsir atkypgrsns tfhywpwfaa 61 stllatslyy rdrpvqnddk tdafpshtes iqvdssvsdf pltitalnfp vsttfkllgy 121 gqrhvtflrf kvyalglyla endenlvsdt lnetylhkyf ldvddsktpk enlarllkrd 181 dsksvmmidd lldsgmrmla kitpvrntdf khlkeglvkt iskhpdvann kdtlakglse 241 lndafsrkgs vrknddliie llangalqfs yhdsknnefe vmgvvnnqlv gkflfsqylc 301 gekspspqak ktaidklitl l // LOCUS NP_012069 310 aa linear PLN 30-JUN-2025 DEFINITION Aim46p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012069 VERSION NP_012069.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179330.3 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 310) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06891. On Jul 30, 2012 this sequence version replaced NP_012069.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..310 /product="Aim46p" /calculated_mol_wt="33982" Region 97..303 /region_name="Chalcone_2" /note="Chalcone isomerase like; pfam16035" /db_xref="CDD:435089" CDS 1..310 /gene="AIM46" /locus_tag="YHR199C" /gene_synonym="FMP34" /coded_by="NM_001179330.3:1..933" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:36739946]" /experiment="EXISTENCE:direct assay:GO:0020037 heme binding [PMID:36739946]" /experiment="EXISTENCE:mutant phenotype:GO:0020037 heme binding [PMID:36739946]" /note="Hemoprotein; hypothetical protein that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity" /db_xref="GeneID:856606" /db_xref="SGD:S000001242" ORIGIN 1 mrliskvlvk tnclevgmrr apqwyshyst tagnarvnkk gskvvpvltg lalasifakk 61 wyddsqikka datsvavdas isafpkkmgp pqwpfstqye ligkgvrcvs sitfkayglg 121 iyvaaedkhl vsevldskfl sqafidtaap pspenshqdn lraalndpak apilinnlld 181 sgirlmsknt pikagsfkll mdgtkksvlk npdsqsqdkd rleagfqelh dcfrsvkglv 241 ardddffiel nkdcsmnlsy yarkkdefvi lgtvkeplig kllfahylaa vdppspeark 301 evidalvsls // LOCUS NP_976247 73 aa linear PLN 30-JUN-2025 DEFINITION borealin [Saccharomyces cerevisiae S288C]. ACCESSION NP_976247 VERSION NP_976247.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184671.1 REFERENCE 1 (residues 1 to 73) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 73) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 73) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 73) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06892. Method: conceptual translation. FEATURES Location/Qualifiers source 1..73 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..73 /product="borealin" /calculated_mol_wt="8416" CDS 1..73 /gene="NBL1" /locus_tag="YHR199C-A" /coded_by="NM_001184671.1:1..222" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:19158380]" /experiment="EXISTENCE:direct assay:GO:0032133 chromosome passenger complex [PMID:19158380]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:19158380]" /note="Subunit of the conserved chromosomal passenger complex (CPC); complex regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p; other complex members are Ipl1p, Sli15p, and Bir1p" /db_xref="GeneID:2746858" /db_xref="SGD:S000029704" ORIGIN 1 mipaltpeer qklrsailhr mqlelettek lienikeetl kklnllqqpd atsapqskel 61 irevleqegr rie // LOCUS NP_012070 268 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle base subunit RPN10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012070 VERSION NP_012070.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179331.3 REFERENCE 1 (residues 1 to 268) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 268) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 268) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 268) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06893. On Jul 30, 2012 this sequence version replaced NP_012070.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..268 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..268 /product="proteasome regulatory particle base subunit RPN10" /calculated_mol_wt="29616" Region 1..189 /region_name="VWA_26S_proteasome_subunit" /note="26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of...; cd01452" /db_xref="CDD:238729" Site order(11,13,64) /site_type="active" /note="partial signature motif [active]" /db_xref="CDD:238729" CDS 1..268 /gene="RPN10" /locus_tag="YHR200W" /gene_synonym="MCB1; SUN1" /coded_by="NM_001179331.3:1..807" /experiment="EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626]" /experiment="EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:8887631]" /experiment="EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:20941496]" /experiment="EXISTENCE:mutant phenotype:GO:0000502 proteasome complex [PMID:15242647]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15242647]" /note="Proteasome polyubiquitin receptor; non-ATPase subunit of the 19S regulatory particle (RP) of the 26S proteasome that links the RP base to the lid; N-terminus plays a role in the assembly of the regulatory particle (RP); ubiquitin-interacting motif selectively binds to polyubiquitin chains; homolog of the mammalian S5a protein" /db_xref="GeneID:856607" /db_xref="SGD:S000001243" ORIGIN 1 mvleatvlvi dnseysrngd fprtrfeaqi dsvefifqak rnsnpentvg lisgaganpr 61 vlstftaefg kilaglhdtq iegklhmata lqiaqltlkh rqnkvqhqri vafvcspisd 121 srdelirlak tlkknnvavd iinfgeieqn telldefiaa vnnpqeetsh lltvtpgprl 181 lyeniasspi ileegssgmg afggsggdsd angtfmdfgv dpsmdpelam alrlsmeeeq 241 qrqerlrqqq qqqdqpeqse qpeqhqdk // LOCUS NP_012071 397 aa linear PLN 30-JUN-2025 DEFINITION exopolyphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012071 VERSION NP_012071.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179332.1 REFERENCE 1 (residues 1 to 397) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 397) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 397) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 397) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06894. Method: conceptual translation. FEATURES Location/Qualifiers source 1..397 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..397 /product="exopolyphosphatase" /EC_number="3.6.1.11" /calculated_mol_wt="44920" Region 30..393 /region_name="PPX1" /note="Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion]; COG1227" /db_xref="CDD:440840" CDS 1..397 /gene="PPX1" /locus_tag="YHR201C" /coded_by="NM_001179332.1:1..1194" /experiment="EXISTENCE:direct assay:GO:0004309 exopolyphosphatase activity [PMID:31175919|PMID:7860598|PMID:17215253]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7860598]" /experiment="EXISTENCE:direct assay:GO:0006798 polyphosphate catabolic process [PMID:8157625]" /experiment="EXISTENCE:mutant phenotype:GO:0004309 exopolyphosphatase activity [PMID:7860598]" /experiment="EXISTENCE:mutant phenotype:GO:0005759 mitochondrial matrix [PMID:12946255]" /experiment="EXISTENCE:mutant phenotype:GO:0006798 polyphosphate catabolic process [PMID:7860598]" /note="Exopolyphosphatase; hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix" /db_xref="GeneID:856608" /db_xref="SGD:S000001244" ORIGIN 1 msplrktvpe flahlkslpi skiasndvlt icvgnesadm dsiasaitys ycqyiynegt 61 yseekkkgsf ivpiidipre dlslrrdvmy vleklkikee elffiedlks lkqnvsqgte 121 lnsylvdnnd tpknlknyid nvvgiidhhf dlqkhldaep rivkvsgscs slvfnywyek 181 lqgdrevvmn iapllmgail idtsnmrrkv eesdklaier cqavlsgavn evsaqgleds 241 sefykeiksr kndikgfsvs dilkkdykqf nfqgkghkgl eiglssivkr mswlfnehgg 301 eadfvnqcrr fqaergldvl vlltswrkag dshrelvilg dsnvvrelie rvsdklqlql 361 fggnldggva mfkqlnveat rkqvvpylee aysnlee // LOCUS NP_012072 602 aa linear PLN 30-JUN-2025 DEFINITION Smn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012072 VERSION NP_012072.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179333.3 REFERENCE 1 (residues 1 to 602) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 602) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 602) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 602) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06895. On Jul 30, 2012 this sequence version replaced NP_012072.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..602 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..602 /product="Smn1p" /calculated_mol_wt="68867" Region 39..325 /region_name="MPP_YHR202W_N" /note="Saccharomyces cerevisiae YHR202W and related proteins, N-terminal metallophosphatase domain; cd07407" /db_xref="CDD:277352" Site order(51,53,97,131..132,241,274,276) /site_type="active" /note="putative active site [active]" /db_xref="CDD:277352" Site order(51,53,97,131,241,274,276) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:277352" CDS 1..602 /gene="SMN1" /locus_tag="YHR202W" /coded_by="NM_001179333.3:1..1809" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:35123996]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11935221]" /experiment="EXISTENCE:mutant phenotype:GO:0019677 NAD+ catabolic process [PMID:35123996]" /note="Putative AMP hydrolase; secreted protein proposed to function as an adenosine monophosphatase in NAD+ degradation, via nucleoside salvage pathway that converts NAD+ to AMP and adenosine; overexpression results in adenosine accumulation and reduced levels of NAD+, deletion results in increased NAD+ and NADH; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; similar to human NT5E/CD73 gene involved in cancer progression" /db_xref="GeneID:856609" /db_xref="SGD:S000001245" ORIGIN 1 milklvhclv altglifakp yqqqqavlap sqdvplrdih igdinfihtt dthgwlgshl 61 sqndydadwg dfvafvdilr ekilrqsrdv ividtgdkrd gnglsdatwp pglrsseifn 121 mmdydlltlg nhelytaesa ileyrgtsqs skfkdkyvcs nvefieddgt rvpfgnkyit 181 fetpimkqrv lalsflfsfq rannraivtp pleeitqksw fqnmvetnre eeidliivfg 241 hlpatdpter emhkihalir kyypntviqy fgghthirdf vqldskstcl qsgrfaetvg 301 flsinmtdpv daespifsrr yidfnkeafk yhlsklghds nvpvstkkgk tisrlvndlr 361 helnlneklg yipqtyyvst rplnseenly hlithkilpn lippknyeps msrfilintg 421 svrydlykgp ftkdteyivm pfnndwrfit vplvvasrve tylnkgpvia slgipssshh 481 kqhfggfqkc pfinnpnlse gytteddfgc hgddtphnsq reydipnvvq ckevkkvqee 541 eadpskmvhv ifysfmeldi lnavnsiind lglrmenltt ndcshyggds tkkllrdyfs 601 qf // LOCUS NP_012073 261 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS4 RPS4B [Saccharomyces cerevisiae S288C]. ACCESSION NP_012073 VERSION NP_012073.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179334.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 261) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06896. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..261 /product="40S ribosomal protein eS4 RPS4B" /calculated_mol_wt="29279" Region 1..259 /region_name="PLN00036" /note="40S ribosomal protein S4; Provisional" /db_xref="CDD:177670" CDS 1..261 /gene="RPS4B" /locus_tag="YHR203C" /coded_by="NM_001179334.1:1..786" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4B has a paralog, RPS4A, that arose from the whole genome duplication" /db_xref="GeneID:856610" /db_xref="SGD:S000001246" ORIGIN 1 margpkkhlk rlaaphhwll dklsgcyapr psagphklre slplivflrn rlkyalngre 61 vkailmqrhv kvdgkvrtdt typagfmdvi tldatnenfr lvydvkgrfa vhritdeeas 121 yklgkvkkvq lgkkgvpyvv thdgrtiryp dpnikvndtv kidlasgkit dfikfdagkl 181 vyvtggrnlg rigtivhker hdggfdlvhi kdsldntfvt rlnnvfvige qgkpyislpk 241 gkgiklsiae erdrrraqqg l // LOCUS NP_012074 796 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,2-mannosidase MNL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012074 VERSION NP_012074.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179335.3 REFERENCE 1 (residues 1 to 796) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 796) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 796) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 796) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06897. On Jul 30, 2012 this sequence version replaced NP_012074.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..796 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..796 /product="alpha-1,2-mannosidase MNL1" /EC_number="3.2.1.24" /calculated_mol_wt="91115" Region 42..502 /region_name="Glyco_hydro_47" /note="Glycosyl hydrolase family 47; pfam01532" /db_xref="CDD:460241" Region <557..594 /region_name="BRCT" /note="C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; cl00038" /db_xref="CDD:469589" CDS 1..796 /gene="MNL1" /locus_tag="YHR204W" /gene_synonym="HTM1" /coded_by="NM_001179335.3:1..2391" /experiment="EXISTENCE:direct assay:GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [PMID:27053108|PMID:21700223]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:19279007]" /experiment="EXISTENCE:direct assay:GO:0036508 protein alpha-1,2-demannosylation [PMID:21700223]" /experiment="EXISTENCE:direct assay:GO:1904382 mannose trimming involved in glycoprotein ERAD pathway [PMID:27053108]" /experiment="EXISTENCE:genetic interaction:GO:1904382 mannose trimming involved in glycoprotein ERAD pathway [PMID:21700223]" /experiment="EXISTENCE:mutant phenotype:GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [PMID:19124653]" /experiment="EXISTENCE:mutant phenotype:GO:0030246 carbohydrate binding [PMID:11375935]" /experiment="EXISTENCE:mutant phenotype:GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway [PMID:11254655|PMID:11375935]" /experiment="EXISTENCE:mutant phenotype:GO:1904380 endoplasmic reticulum mannose trimming [PMID:27053108]" /experiment="EXISTENCE:mutant phenotype:GO:1904382 mannose trimming involved in glycoprotein ERAD pathway [PMID:19124653|PMID:27053108]" /note="Alpha-1,2-specific exomannosidase of the ER; involved in glycan trimming of both folded and misfolded glycoproteins; complexes with Pdi1p, and recognizes misfolded, globular glycoproteins through the C-terminal domain, trimming a mannose from Man8GlcNac2 glycan to generate Man7GlcNac2, an oligosaccharide signal for ER-associated protein degradation (ERAD); modifies Pdi1p redox reactions; requires Pdi1p for stability and substrate recognition; human homolog EDEM1 can complement yeast null mutant" /db_xref="GeneID:856611" /db_xref="SGD:S000001247" ORIGIN 1 mvcclwvlla lllhldhvac eddaysftsk elkaykqevk elfyfgfdny lehgypydev 61 kpiscvpkkr nfedptdqgt ndilgnftit lidslttiai ledrpqflka vrlvertfpd 121 gnfdidstiq vfeitirvig sllsshlyat dptkavylgd dydgsllrla qnmadrllpa 181 yltstglpmp rrnikrkwdv sefpeflete nnvaamaspm feftilsylt gdpkyekvtr 241 yafdktwslr tgldllpmsf hpekltpytp mtgigasids lfeyalkgai lfddselmev 301 wnvayealkt nckndwffan vmadtghlfv pwidslsaff sglqvlagdl ddaianhlmf 361 lkmwntfggi perwnfsppe fpplsplers gavaldnilp lewyplrpef festyflyra 421 tkdpfylnig vhllkdlkqr fksncgfagf qnvitgelqd rmetfvlset lkylyllfde 481 enelhnsasd vifsteahpm wlpqevrsny krnakfnnsv ysshleicqk kdreqagent 541 lsqrivgfak sifhkgppde eatdpiidyt idtelpgtcs ikphhvigde fwyspmlsnf 601 drlfeidsrf aatlikpshm hnynaielep gfynrwsnpq fstclipptt eifellfdlp 661 gyhqlnplml enktitfetf ggrsrlkiek lqiyqidyyg dlitastfqd vsrkdifsna 721 cdavaslysp tylyrvvain grilprhgsv qikkhspvlt sngtreedef kmdgigindh 781 sqlmlectpi inlfiv // LOCUS NP_012075 824 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase SCH9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012075 VERSION NP_012075.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179336.1 REFERENCE 1 (residues 1 to 824) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 824) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 824) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 824) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 824) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 824) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 824) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06898. Method: conceptual translation. FEATURES Location/Qualifiers source 1..824 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..824 /product="serine/threonine protein kinase SCH9" /EC_number="2.7.11.1" /calculated_mol_wt="91681" Region 181..407 /region_name="YPK1_N_like" /note="Fungal protein kinase domain similar to the N-terminus of YPK1; cd11651" /db_xref="CDD:212165" Region 418..738 /region_name="STKc_Sck1_like" /note="Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases; cd05586" /db_xref="CDD:270738" Site order(418..422,426,439,441,476,492..493,495,499,501,538, 540,542..543,545,555..556,559,571..576,604,610,613) /site_type="active" /db_xref="CDD:270738" Site order(418..422,426,439,441,476,493..495,499,538,540, 542..543,545,555..556) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270738" Site order(422,499,501,538,540,542,559,571..576,604,610,613) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270738" Site order(555..566,568..576) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270738" Site 733..738 /site_type="other" /note="hydrophobic motif (HM)" /db_xref="CDD:270738" CDS 1..824 /gene="SCH9" /locus_tag="YHR205W" /gene_synonym="HRM2; KOM1" /coded_by="NM_001179336.1:1..2475" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19748353|PMID:22842922|PMID:15466158|PMID:17560372]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:17568771]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:25921291|PMID:17568771]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15466158]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:19159085]" /experiment="EXISTENCE:genetic interaction:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:19684113]" /experiment="EXISTENCE:genetic interaction:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:19684113]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:17568771]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:19684113]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17568771]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:19684113]" /experiment="EXISTENCE:mutant phenotype:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:19684113]" /experiment="EXISTENCE:mutant phenotype:GO:0047484 regulation of response to osmotic stress [PMID:17568771]" /experiment="EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15466158]" /experiment="EXISTENCE:mutant phenotype:GO:0090153 regulation of sphingolipid biosynthetic process [PMID:24196832]" /experiment="EXISTENCE:mutant phenotype:GO:1901494 regulation of cysteine metabolic process [PMID:31582588]" /experiment="EXISTENCE:mutant phenotype:GO:1904828 positive regulation of hydrogen sulfide biosynthetic process [PMID:31582588]" /note="AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan" /db_xref="GeneID:856612" /db_xref="SGD:S000001248" ORIGIN 1 mmnfftskss nqdtgfssqh qhpngqnngn nnsstagndn gypcklvssg pcassnngal 61 ftnftlqtat pttaisqdly amgttgitse nalfqmksmn ngissvnnnn sntptiitts 121 qeetnagnvh gdtggnslqn seddnfssss ttkcllssts slsinqreaa aaaygpdtdi 181 prgklevtii eardlvtrsk dsqpyvvctf essefisngp eslgainnnn nnnnnnqhnq 241 nqhinnnnen tnpdaasqhh nnnsgwngsq lpsikehlkk kplythrsss qldqlnscss 301 vtdpskrssn sssgssngpk ndsshpiwhh kttfdvlgsh seldisvyda ahdhmflgqv 361 rlypmihnla hasqhqwhsl kprvidevvs gdilikwtyk qtkkrhygpq dfevlrllgk 421 gtfgqvyqvk kkdtqriyam kvlskkvivk kneiahtige rnilvttask sspfivglkf 481 sfqtptdlyl vtdymsggel fwhlqkegrf sedrakfyia elvlalehlh dndivyrdlk 541 penilldang nialcdfgls kadlkdrtnt fcgtteylap ellldetgyt kmvdfwslgv 601 lifemccgws pffaennqkm yqkiafgkvk fprdvlsqeg rsfvkgllnr npkhrlgaid 661 dgrelrahpf fadidwealk qkkipppfkp hlvsetdtsn fdpefttast symnkhqpmm 721 tatplspamq akfagftfvd esaidehvnn nrkflqnsyf mepgsfipgn pnlppdedvi 781 dddgdedind gfnqeknmnn shsqmdfdgd qhmddefvsg rfei // LOCUS NP_012076 622 aa linear PLN 30-JUN-2025 DEFINITION kinase-regulated stress-responsive transcription factor SKN7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012076 VERSION NP_012076.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179337.3 REFERENCE 1 (residues 1 to 622) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 622) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 622) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 622) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06899. On Jul 30, 2012 this sequence version replaced NP_012076.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..622 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..622 /product="kinase-regulated stress-responsive transcription factor SKN7" /calculated_mol_wt="69071" Region 75..350 /region_name="HSF1" /note="Heat shock transcription factor [Transcription]; COG5169" /db_xref="CDD:227497" Region 379..488 /region_name="REC_hyHK_CKI1_RcsC-like" /note="phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; cd17546" /db_xref="CDD:381099" Site order(385,387..388,390..391,394..395,398,456,478,480..481) /site_type="other" /note="Hpt domain binding site [polypeptide binding]" /db_xref="CDD:381099" CDS 1..622 /gene="SKN7" /locus_tag="YHR206W" /gene_synonym="BRY1; POS9" /coded_by="NM_001179337.3:1..1869" /experiment="EXISTENCE:direct assay:GO:0000156 phosphorelay response regulator activity [PMID:11073911]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:9118942|PMID:11854400]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10888672|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:11854400|PMID:9118942]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0000156 phosphorelay response regulator activity [PMID:11073911]" /experiment="EXISTENCE:mutant phenotype:GO:0000304 response to singlet oxygen [PMID:16862604]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:9118942]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:17965252]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:9118942]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:17302939]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17965252]" /experiment="EXISTENCE:mutant phenotype:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:27373166]" /note="Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; involved in osmoregulation; relocalizes to the cytosol in response to hypoxia; SKN7 has a paralog, HMS2, that arose from the whole genome duplication" /db_xref="GeneID:856613" /db_xref="SGD:S000001249" ORIGIN 1 msfstinsnv nkttgdsnnn ttensstadl lgmdllqsgp rlmntmqpnn ssdmlhinnk 61 tnnvqqpagn tnissanaga kapanefvrk lfrilenney pdivtwteng ksfvvldtgk 121 ftthilpnhf khsnfasfvr qlnkydfhkv krspeerqrc kygeqswefq hpefrvhygk 181 gldnikrkip aqrkvlldes qkallhfnse gtnpnnpsgs llnesttell lsntvskdaf 241 gnlrrrvdkl qkeldmskme syatkvelqk lnskyntvie slitfktine nllnnfntlc 301 stlanngiev pifgdngnrn ptgntnpatt taiqsnnntn naspatstvs lqlpnlpdqn 361 sltpnaqnnt vtlrkgfhvl lveddavsiq lcskflrkyg ctvqvvsdgl saistlekyr 421 ydlvlmdivm pnldgatats ivrsfdnetp iiamtgnimn qdlitylqhg mndilakpft 481 rddlhsilir ylkdriplce qqlpprnssp qthsntntan snpntineqs lamlpqdnps 541 tttpvtpgas issaqhvqqg qqeqqhqifh aqqqqqhhna ianarsdvai pnleheintv 601 phssmgstpq lpqstlqenq ls // LOCUS NP_012077 526 aa linear PLN 30-JUN-2025 DEFINITION S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012077 VERSION NP_012077.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179338.1 REFERENCE 1 (residues 1 to 526) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 526) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 526) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 526) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06900. Method: conceptual translation. FEATURES Location/Qualifiers source 1..526 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..526 /product="S-adenosylmethionine-dependent methyltransferase" /calculated_mol_wt="60416" Region 114..>147 /region_name="SET" /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; cl40432" /db_xref="CDD:394802" Region <352..429 /region_name="SET_SMYD" /note="SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; cd20071" /db_xref="CDD:380997" Site order(369,424,426,429) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:380997" CDS 1..526 /gene="SET5" /locus_tag="YHR207C" /coded_by="NM_001179338.1:1..1581" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:22343720]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:22343720]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:27911222]" /note="Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus" /db_xref="GeneID:856614" /db_xref="SGD:S000001250" ORIGIN 1 mtltikigtl ndsdqsavhn gtengsdfrk itpteeeicd dvvllwkeep gtedatiqhl 61 ydriternqs wklsasrfrk ilnehhlydt dletvslykd kihfpkalds dakvevkfid 121 dehgrglfak rdfskgqiil kenkpivyip pldklflisn gkacarcgka lydltqhkim 181 vhyldcevck aiwcsekckk ahaslhelly hswrsnridi lhagnwkrfv nycekycfta 241 afsvgliygs mlldttgevk eqwqklasis qreriklrda sgigstfsll ngttvhteee 301 sdngtkkgve kniddetvwe kcyelfcgaf pkaseeidfe kfltmigtfn inqyngqvyh 361 wisfinhdce pnayieqvee heelrlhark pikkgeqiri tyvnplhgvr lrrrelrvnw 421 gflcqcdrcq nelstfervp nlekknadan lgvekidsnd ssedgskkst gnrkssmrea 481 qpdlkeilkn gkefeldipe tvdtqgnvrk tsvrfdsnvs vavder // LOCUS NP_012078 393 aa linear PLN 30-JUN-2025 DEFINITION branched-chain-amino-acid transaminase BAT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012078 VERSION NP_012078.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179339.3 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 393) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06901. On Jul 30, 2012 this sequence version replaced NP_012078.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..393 /product="branched-chain-amino-acid transaminase BAT1" /EC_number="2.6.1.42" /calculated_mol_wt="43465" Region 78..378 /region_name="BCAT_beta_family" /note="Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The...; cd01557" /db_xref="CDD:238798" Site order(78..82,85..89,91,93,124,161,163,169..171,175,182,221, 226,228,232,246) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:238798" Site order(88,93,117,173,219,224,254,287..288,334) /site_type="active" /note="substrate-cofactor binding pocket [active]" /db_xref="CDD:238798" Site 219 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:238798" CDS 1..393 /gene="BAT1" /locus_tag="YHR208W" /gene_synonym="ECA39; TWT1" /coded_by="NM_001179339.3:1..1182" /experiment="EXISTENCE:direct assay:GO:0004084 branched-chain-amino-acid transaminase activity [PMID:8798704]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8798704]" /experiment="EXISTENCE:direct assay:GO:0009082 branched-chain amino acid biosynthetic process [PMID:8798704]" /experiment="EXISTENCE:mutant phenotype:GO:0009082 branched-chain amino acid biosynthetic process [PMID:8798704]" /experiment="EXISTENCE:mutant phenotype:GO:0009083 branched-chain amino acid catabolic process [PMID:8702755]" /note="Mitochondrial branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase; BAT1 has a paralog, BAT2, that arose from the whole genome duplication" /db_xref="GeneID:856615" /db_xref="SGD:S000001251" ORIGIN 1 mlqrhslklg kfsirtlatg apldasklki trnpnpskpr pneelvfgqt ftdhmltipw 61 sakegwgtph ikpygnlsld psacvfhyaf elfeglkayr tpqntitmfr pdknmarmnk 121 saariclptf eseelikltg klieqdkhlv pqgngyslyi rptmigtskg lgvgtpseal 181 lyvitspvgp yyktgfkavr leatdyatra wpggvgdkkl ganyapcilp qlqaakrgyq 241 qnlwlfgpek nitevgtmnv ffvflnkvtg kkelvtapld gtilegvtrd svltlardkl 301 dpqewdiner yytitevatr akqgelleaf gsgtaavvsp ikeigwnned ihvpllpgeq 361 cgaltkqvaq wiadiqygrv nygnwsktva dln // LOCUS NP_012079 291 aa linear PLN 30-JUN-2025 DEFINITION S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012079 VERSION NP_012079.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179340.1 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 291) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06902. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..291 /product="S-adenosylmethionine-dependent methyltransferase" /calculated_mol_wt="33654" Region 16..155 /region_name="UbiE" /note="Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; COG2226" /db_xref="CDD:441828" CDS 1..291 /gene="CRG1" /locus_tag="YHR209W" /coded_by="NM_001179340.1:1..876" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:22028670]" /experiment="EXISTENCE:mutant phenotype:GO:0008168 methyltransferase activity [PMID:22028670]" /experiment="EXISTENCE:mutant phenotype:GO:0055088 lipid homeostasis [PMID:22028670]" /note="S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin" /db_xref="GeneID:856616" /db_xref="SGD:S000001252" ORIGIN 1 mpktsylnkn fesahynnvr psyplslvne imkfhkgtrk slvdigcgtg katfvvepyf 61 kevigidpss amlsiaeket nerrldkkir finapgedls sirpesvdmv isaeaihwcn 121 lerlfqqvss ilrsdgtfaf wfyiqpefvd fpealnvyyk ygwskdymgk ylndnqreil 181 lnyggeklrs llsdrfgdie vtiyspsdpn astvtaensq flwraaitln qfkefvksws 241 iytswardnp skpdiadifi nelkeichce dlnvplkiew stfyylcrkr e // LOCUS NP_012080 341 aa linear PLN 30-JUN-2025 DEFINITION aldose 1-epimerase superfamily protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012080 VERSION NP_012080.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179341.3 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 341) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06903. On Jul 30, 2012 this sequence version replaced NP_012080.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..341 /product="aldose 1-epimerase superfamily protein" /calculated_mol_wt="37802" Region 13..339 /region_name="galactose_mutarotase_like" /note="galactose mutarotase_like; cd09019" /db_xref="CDD:185696" Site order(59,70,95,175,177,239,288,306) /site_type="active" /db_xref="CDD:185696" Site order(175,306) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:185696" CDS 1..341 /locus_tag="YHR210C" /coded_by="NM_001179341.3:1..1026" /note="Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions" /db_xref="GeneID:856617" /db_xref="SGD:S000001253" ORIGIN 1 msnnkaggey evitigdakk lqatiselga tlldlkvnne sivlgypdih gyisdgynyi 61 gatvgryanr iykgmfsmed gphqltvnnc gntnhssiss fhlkkykask vqnplddlyi 121 veftllddrt lpnefpgdla vnlkytlnva dmtldleyea klvsgeatpi nmtnhtyfnl 181 nktmdkksis gtevrlcsdk slevsegali ptgkivqrki atfdsskpti lqddgpiydy 241 afivdenknl kttdsvsvnk lvpafkayhp asrlslevst teptvlfytg dnlcdgftpr 301 sgfaveqgry vdainrdgwr dcvllrrgev ytsktryrfa v // LOCUS NP_012081 1075 aa linear PLN 30-JUN-2025 DEFINITION flocculin FLO5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012081 VERSION NP_012081.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179342.1 REFERENCE 1 (residues 1 to 1075) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1075) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1075) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1075) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1075) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1075) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1075) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06904. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1075 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1075 /product="flocculin FLO5" /calculated_mol_wt="111851" Region 100..249 /region_name="PA14" /note="PA14 domain; pfam07691" /db_xref="CDD:400161" Region 503..540 /region_name="Flocculin" /note="Flocculin repeat; pfam00624" /db_xref="CDD:395499" Region 784..825 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" Region 859..897 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" Region 905..948 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" CDS 1..1075 /gene="FLO5" /locus_tag="YHR211W" /coded_by="NM_001179342.1:1..3228" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9483793]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000128 flocculation [PMID:19087208|PMID:19420680]" /experiment="EXISTENCE:mutant phenotype:GO:0005537 D-mannose binding [PMID:2665372]" /experiment="EXISTENCE:mutant phenotype:GO:0031589 cell-substrate adhesion [PMID:19087208]" /note="Lectin-like cell wall protein (flocculin) involved in flocculation; binds mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; important for co-flocculation with other yeasts, mediating interaction with specific species; FLO5 has a paralog, FLO1, that arose from a segmental duplication" /db_xref="GeneID:856618" /db_xref="SGD:S000001254" ORIGIN 1 mtiahhcifl vilaflalin vasgateacl pagqrksgmn infyqyslkd sstysnaaym 61 aygyasktkl gsvggqtdis idynipcvss sgtfpcpqed sygnwgckgm gacsnsqgia 121 ywstdlfgfy ttptnvtlem tgyflppqtg sytfsfatvd dsailsvggs iafeccaqeq 181 ppitstnfti ngikpwdgsl pdnitgtvym yagyyyplkv vysnavswgt lpisvelpdg 241 ttvsdnfegy vysfdddlsq snctipdpsi httstitttt epwtgtftst stemttitdt 301 ngqltdetvi virtpttast ittttepwtg tftststemt tvtgtngqpt detvivirtp 361 tseglitttt epwtgtftst stemttvtgt ngqptdetvi virtptsegl ittttepwtg 421 tftststevt titgtngqpt detvivirtp tseglitttt epwtgtftst stemttvtgt 481 ngqptdetvi virtptsegl istttepwtg tftststevt titgtngqpt detvivirtp 541 tseglitttt epwtgtftst stemttvtgt ngqptdetvi virtptsegl itrttepwtg 601 tftststevt titgtngqpt detvivirtp ttaissslss ssgqitssit ssrpiitpfy 661 psngtsviss svisssvtss lvtsssfiss svisssttts tsifsessts sviptsssts 721 gssesktssa ssssssssis sespksptns ssslppvtsa ttgqetassl ppatttktse 781 qttlvtvtsc eshvctesis saivstatvt vsgvtteytt wcpisttett kqtkgtteqt 841 kgtteqttet tkqttvvtis scesdicskt aspaivstst atingvttey ttwcpistte 901 skqqttlvtv tscesgvcse ttspaivsta tatvndvvtv yptwrpqttn eqsvsskmns 961 atsetttntg aaetktavts slsrfnhaet qtasatdvig hsssvvsvse tgntmsltss 1021 glstmsqqpr stpassmvgs stasleisty agsansllag sglsvfiasl llaii // LOCUS NP_878091 67 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR212W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878091 VERSION NP_878091.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184598.3 REFERENCE 1 (residues 1 to 67) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 67) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 67) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 67) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06905. On Jul 30, 2012 this sequence version replaced NP_878091.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..67 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..67 /product="uncharacterized protein" /calculated_mol_wt="7478" CDS 1..67 /locus_tag="YHR212W-A" /coded_by="NM_001184598.3:1..204" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YHR212W-A has a paralog, YAR061W, that arose from a segmental duplication" /db_xref="GeneID:1466531" /db_xref="SGD:S000028650" ORIGIN 1 mpyhylflal ftylatsnvv sgstqaclpv gprkngmnvn fykyslldst tysypqymts 61 gyasnwn // LOCUS NP_012083 198 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR213W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012083 VERSION NP_012083.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179344.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 198) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06906. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..198 /product="uncharacterized protein" /calculated_mol_wt="21014" Region <1..110 /region_name="PA14" /note="PA14 domain; cl08459" /db_xref="CDD:471833" CDS 1..198 /locus_tag="YHR213W" /coded_by="NM_001179344.1:1..597" /note="Pseudogenic fragment with similarity to flocculins; YHR213W has a paralog, YAR062W, that arose from a segmental duplication" /db_xref="GeneID:856620" /db_xref="SGD:S000001256" ORIGIN 1 mtgyflppqt ssytfrfakv ddsailsvgg nvafeccaqe qppitstdft ingikpwqgs 61 lpdniggtvy myagyyyplk vvysnavswg tlpisvelpd gttvsddfeg yvysfdddls 121 qsnctipdps khttsivttt telwtgtfts tstemttvtg tngqptdetv ivakapttat 181 ssslssssse qitssits // LOCUS NP_878092 77 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR213W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878092 VERSION NP_878092.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184599.3 REFERENCE 1 (residues 1 to 77) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 77) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 77) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 77) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 77) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06907. On Jul 30, 2012 this sequence version replaced NP_878092.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..77 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..77 /product="uncharacterized protein" /calculated_mol_wt="8795" CDS 1..77 /locus_tag="YHR213W-A" /coded_by="NM_001184599.3:1..234" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466532" /db_xref="SGD:S000028651" ORIGIN 1 mlaktgdvvv qkvpvirlsv flhfffvfpf cllhrlymgm kqvqefimep kgsvfvvrat 61 lrvslenagk iffnete // LOCUS NP_878093 99 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR213W-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878093 VERSION NP_878093.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184600.1 REFERENCE 1 (residues 1 to 99) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 99) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 99) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 99) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06908. Method: conceptual translation. FEATURES Location/Qualifiers source 1..99 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..99 /product="uncharacterized protein" /calculated_mol_wt="11053" CDS 1..99 /locus_tag="YHR213W-B" /coded_by="NM_001184600.1:1..300" /note="Pseudogenic fragment with similarity to flocculins; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YHR213W-B has a paralog, YAR064W, that arose from a segmental duplication" /db_xref="GeneID:1466533" /db_xref="SGD:S000028652" ORIGIN 1 mlidfccsyi agthgrerap sftgtfvshv saenncrprr seitqpcasg tekkhfaate 61 kqctnslegs rkdflslplg hsylflfcfw rmicsepkl // LOCUS NP_012084 203 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR214W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012084 VERSION NP_012084.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179345.3 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 203) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06909. On Jul 30, 2012 this sequence version replaced NP_012084.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..203 /product="uncharacterized protein" /calculated_mol_wt="20462" CDS 1..203 /locus_tag="YHR214W" /coded_by="NM_001179345.3:1..612" /note="hypothetical protein; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein; YHR214W has a paralog, YAR066W, that arose from a segmental duplication" /db_xref="GeneID:856621" /db_xref="SGD:S000001257" ORIGIN 1 mfnrfnkfqa avalallsrg algdsytnst ssadlssits vssasasata sdslsssdgt 61 vylpsttisg dltvtgkvia teavevaagg kltlldgeky vfssdlkvhg dlvvekseas 121 yegtafdvsg etfevsgnfs aeetgavsas iysftpssfk ssgdislsls kakkgevtfs 181 pysnagtfsl snailnggsv sgl // LOCUS NP_012086 1793 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012086 VERSION NP_012086.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181431.2 REFERENCE 1 (residues 1 to 1793) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1793) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1793) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 1793) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06910. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1793 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..1793 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="202687" Region 17..438 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 702..803 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region <945..1201 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" Region 1303..1536 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1644..1780 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1648..1651,1685..1687,1690,1723,1750,1777) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1793 /locus_tag="YHR214C-B" /coded_by="join(NM_001181431.2:1..1416, NM_001181431.2:1418..5383)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes; YHR214C-B has a paralog, YAR070C, that arose from a segmental duplication" /db_xref="GeneID:856623" /db_xref="SGD:S000003534" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenlhha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvp pmltspndfp nwvktyikfl qnsnlggiip 241 tvngkpvrqi tddeltflyn tfqifapsqf lptwvkdils vdytdimkil sksiekmqsd 301 tqeandivtl anlqyngstp adafetkvtn iidrlnnngi hinnkvacql imrglsgeyk 361 flrytrhrhl nmtvaelfld ihaiyeeqqg srnskpnyrr npsdekndsr sytnttkpkv 421 iarnpqktnn sksktarahn vstsnnspst dndsiskstt epiqlnnkhd lhlgqkltes 481 tvnhtnhsdd elpghlllds gasrtlirsa hhihsassnp dinvvdaqkr nipinaigdl 541 qfhfqdntkt sikvlhtpni aydllslnel aavditacft knvlersdgt vlapivkygd 601 fywvskkyll psnisvptin nvhtsestrk ypypfihrml ahanaqtiry slknntityf 661 nesdvdwssa idyqcpdcli gkstkhrhik gsrlkyqnsy epfqylhtdi fgpvhnlpks 721 apsyfisftd ettkfrwvyp lhdrredsil dvfttilafi knqfqasvlv iqmdrgseyt 781 nrtlhkflek ngitpcyttt adsrahgvae rlnrtllddc rtqlqcsglp nhlwfsaief 841 stivrnslas pkskksarqh aglagldist llpfgqpviv ndhnpnskih prgipgyalh 901 psrnsygyii ylpslkktvd ttnyvilqgk esrldqfnyd altfdedlnr ltasyhsfia 961 sneiqqsndl niesdhdfqs dielhpeqlr nvlskavspt dstppsthte dskrvsktni 1021 raprevdpni sesnilpskk rsstpqisdi estgsggmhr ldvpllapms qsnthessha 1081 skskdfrhsd sysdnetnht nvpisstggt nnktvpqtse qetekriihr spsidtssse 1141 snslhhvvpi ktsdtcpken teesiiadlp lpdlppeppt elsdsfkelp pinshqtnss 1201 lggigdsnay ttinskkrsl edneteikvs rdtwntknmr slepprskkr ihliaavkav 1261 ksikpirttl rydeaitynk dikekekyiq ayhkevnqll mmktwdtdry ydrkeidpkr 1321 vinsmfifnr krdgthkarf vargdiqhpd tydpgmqsnt vhhyalmtsl slaldnnyyi 1381 tqldissayl yadikeelyi rppphlgmnd klirlkksly glkqsganwy etiksylikq 1441 cgmeevrgws cvfknsqvti clfvddmilf skdlnankki ittlkkqydt kiinlgesdn 1501 eiqydilgle ikyqrgkymk lgmensltek ipklnvplnp kgrklsapgq pglyidqdel 1561 eidedeykek vhemqkligl asyvgykfrf dllyyintla qhilfpsrqv ldmtyeliqf 1621 mwdtrdkqli whknkptepd nklvaisdas ygnqpyyksq igniyllngk viggkstkas 1681 ltctstteae ihaisesvpl lnnlshlvqe lnkkpitkgl ltdskstisi iisnneekfr 1741 nrffgtkamr lrdevsgnhl hvcyietkkn iadvmtkplp iktfklltnk wih // LOCUS NP_036195 478 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_036195 VERSION NP_036195.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184437.3 REFERENCE 1 (residues 1 to 478) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 478) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 478) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06911. On Jul 30, 2012 this sequence version replaced NP_036195.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..478 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..478 /product="gag protein" /calculated_mol_wt="53195" Region 17..438 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..478 /locus_tag="YHR214C-C" /coded_by="NM_001184437.3:1..1437" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:856624" /db_xref="SGD:S000007421" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenlhha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvp pmltspndfp nwvktyikfl qnsnlggiip 241 tvngkpvrqi tddeltflyn tfqifapsqf lptwvkdils vdytdimkil sksiekmqsd 301 tqeandivtl anlqyngstp adafetkvtn iidrlnnngi hinnkvacql imrglsgeyk 361 flrytrhrhl nmtvaelfld ihaiyeeqqg srnskpnyrr npsdekndsr sytnttkpkv 421 iarnpqktnn sksktarahn vstsnnspst dndsiskstt epiqlnnkhd lhlrpety // LOCUS NP_878094 97 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR214C-D [Saccharomyces cerevisiae S288C]. ACCESSION NP_878094 VERSION NP_878094.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184601.1 REFERENCE 1 (residues 1 to 97) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 97) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 97) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 97) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06912. Method: conceptual translation. FEATURES Location/Qualifiers source 1..97 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..97 /product="uncharacterized protein" /calculated_mol_wt="10786" CDS 1..97 /locus_tag="YHR214C-D" /coded_by="NM_001184601.1:1..294" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP and mCherry fusion proteins localize to the nucleus and endoplasmic reticulum respectively; YHR214C-D has a paralog, YAR069C, that arose from a segmental duplication" /db_xref="GeneID:1466534" /db_xref="SGD:S000028653" ORIGIN 1 medhtlvaiv vffgngepfh vslsvemvfv lllsstrihe vvvlicyklq hatwswgnms 61 knfslkpdis lsflldiisi ndiciygcia ltvvfil // LOCUS NP_878095 99 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR214C-E [Saccharomyces cerevisiae S288C]. ACCESSION NP_878095 VERSION NP_878095.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184602.3 REFERENCE 1 (residues 1 to 99) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 99) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 99) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 99) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06913. On Jul 30, 2012 this sequence version replaced NP_878095.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..99 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..99 /product="uncharacterized protein" /calculated_mol_wt="11469" CDS 1..99 /locus_tag="YHR214C-E" /coded_by="NM_001184602.3:1..300" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466535" /db_xref="SGD:S000028654" ORIGIN 1 mykittiylw lksylsffig ldnldfltli rffqcrlqnk lglqdildff cnlcghsmvr 61 tcnmveaaqk qnritfgsiy vklhplvklc tgivwaprv // LOCUS NP_012087 467 aa linear PLN 30-JUN-2025 DEFINITION acid phosphatase PHO12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012087 VERSION NP_012087.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179346.1 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 467) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06914. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..467 /product="acid phosphatase PHO12" /EC_number="3.1.3.2" /calculated_mol_wt="52569" Region 65..399 /region_name="His_Phos_2" /note="Histidine phosphatase superfamily (branch 2); pfam00328" /db_xref="CDD:395259" Site order(74..75,78,175,337..338) /site_type="active" /note="catalytic core [active]" /db_xref="CDD:132717" CDS 1..467 /gene="PHO12" /locus_tag="YHR215W" /gene_synonym="PHO10" /coded_by="NM_001179346.1:1..1404" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0003993 acid phosphatase activity [PMID:8817921]" /note="One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; pregulated by phosphate starvation; PHO12 has a paralog, PHO11, that arose from a segmental duplication" /db_xref="GeneID:856625" /db_xref="SGD:S000001258" ORIGIN 1 mlksavysil aaslvnagti plgklsdidk igtqteifpf lggsgpyysf pgdygisrdl 61 pescemkqvq mvgrhgeryp tvskaksimt twyklsnytg qfsgalsfln ddyeffirdt 121 knlemettla nsvnvlnpyt gemnakrhar dflaqygymv enqtsfavft snsnrchdta 181 qyfidglgdk fnislqtise aesagantls ahhscpawdd dvnddilkky dtkylsgiak 241 rlnkenkgln ltssdantff awcayeinar gysdicnift kdelvrfsyg qdletyyqtg 301 pgydvvrsvg anlfnasvkl lkesevqdqk vwlsfthdtd ilnylttigi iddqnnltae 361 hvpfmentfh rswyvpqgar vytekfqcsn dtyvryvind avvpietcst gpgfsceind 421 fygyaekrva gtdflkvcnv ssvsnstelt ffwdwntkhy ndtllkq // LOCUS NP_012088 523 aa linear PLN 30-JUN-2025 DEFINITION IMP dehydrogenase IMD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012088 VERSION NP_012088.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179347.3 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 523) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06915. On Jul 30, 2012 this sequence version replaced NP_012088.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..523 /product="IMP dehydrogenase IMD2" /EC_number="1.1.1.205" /calculated_mol_wt="56399" Region 36..512 /region_name="IMPDH" /note="IMP dehydrogenase / GMP reductase domain; pfam00478" /db_xref="CDD:459826" CDS 1..523 /gene="IMD2" /locus_tag="YHR216W" /gene_synonym="PUR5" /coded_by="NM_001179347.3:1..1572" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:20097157]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:20097157]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:23222640]" /note="Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation; IMD2 has a paralog, YAR073W/YAR075W, that arose from a segmental duplication" /db_xref="GeneID:856626" /db_xref="SGD:S000001259" ORIGIN 1 maairdykta ldftkslprp dglsvqelmd skirggltyn dflilpglvd fassevslqt 61 kltrnitlni plvsspmdtv tesematfma llggigfihh nctpedqadm vrrvknyeng 121 finnpivisp tttvgeaksm kekygfagfp vttdgkrnak lvgvitsrdi qfvednsllv 181 qdvmtknpvt gaqgitlseg neilkkikkg rllvvdekgn lvsmlsrtdl mknqnyplas 241 ksantkqllc gasigtmdad kerlrllvka gldvvildss qgnsifelnm lkwvkesfpg 301 leviagnvvt reqaanliaa gadglrigmg tgsicitqev macgrpqgta vynvcefanq 361 fgvpcmadgg vqnighitka lalgsstvmm ggmlagttes pgeyfyqdgk rlkayrgmgs 421 idamqktgtk gnastsryfs esdsvlvaqg vsgavvdkgs ikkfipylyn glqhscqdig 481 crsltllknn vqrgkvrfef rtasaqlegg vhnlhsyekr lhn // LOCUS NP_012090 603 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR218W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012090 VERSION NP_012090.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179349.1 REFERENCE 1 (residues 1 to 603) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 603) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 603) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 603) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06916. Method: conceptual translation. FEATURES Location/Qualifiers source 1..603 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..603 /product="uncharacterized protein" /calculated_mol_wt="68720" Region 304..476 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" CDS 1..603 /locus_tag="YHR218W" /coded_by="NM_001179349.1:1..1812" /note="Helicase-like protein encoded within the telomeric Y' element" /db_xref="GeneID:856628" /db_xref="SGD:S000001261" ORIGIN 1 mdrkrsfeki vvsvmvgknv qkfltfvede pdfqggpips kylipkkinl mvytlfqvht 61 lkfnrkdydt lslfylnrgy ynelsfrvle rcyeiasarp ndsstmrtft dfvsgtpivr 121 slqkstirky gynlapymfl llhvdelsif sayqaslpge kkvdterlkr dlcprkptei 181 kyfsqicndm mnkkdrlgdv lataqrirrr ynkngssepr lktldgltse rwiqwlgles 241 dyhcsfsstr naedvvagea assdhdqkis rvtrkrprep kstndilvag rklfgssfef 301 rdlhqlrlch eiymadtpsv avqappgygk telfhlplia laskgdvkyv sflfvpytvl 361 lancmirlgr rgclnvapvr nfieegcdgv tdlyvgiydd lastnftdri aawenivect 421 frtnnvklgy livdefhnfe tevyrqsqfg gitnldfdaf ekaiflsgta peavadaalq 481 rigltglakk smdinelkrs edlsrglssy ptrmfnlike ksevplghvh kiwkkvesqp 541 eealklllal feiepeskai vvasttneve elacswrkyf rvvwihgklg ccrkgvshkg 601 vch // LOCUS NP_012091 624 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YHR219W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012091 VERSION NP_012091.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179350.3 REFERENCE 1 (residues 1 to 624) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 624) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 624) AUTHORS Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J., Du,Z., Favello,A., Fulton,L., Gattung,S. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII JOURNAL Science 265 (5181), 2077-2082 (1994) PUBMED 8091229 REFERENCE 4 (residues 1 to 624) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (11-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA06917. On Jul 30, 2012 this sequence version replaced NP_012091.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..624 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="VIII" Protein 1..624 /product="uncharacterized protein" /calculated_mol_wt="69997" CDS 1..624 /locus_tag="YHR219W" /coded_by="NM_001179350.3:1..1875" /note="hypothetical protein with similarity to helicases; located in the telomere region on the right arm of chromosome VIII" /db_xref="GeneID:856629" /db_xref="SGD:S000001262" ORIGIN 1 mdlnqrkekk gqhvgccgsr tdlsadtvel iermdrlaen qatasmsiva lpssfqesns 61 sdrcrkycss dedsdtcihg sanastnatt nsstnattta sinvrtsatt tasinvrtsa 121 tttestnsnt natttestns stnatttasi nvrtsattte stnsntsatt testdsntsa 181 tttestdsnt satttastns stnatttast nsstnattte stnasakeda nkdgnaednr 241 fhpvtdinke sykrkgsqmv llerkklkaq fpntsenmnv lqflgfrsde ikhlflygid 301 iyfcpegvft qyglckgcqk mfelcvcwag qkvsyrrmaw ealavermlr ndeeykeyle 361 diepyhgdpv gylkffsvkr geiysqiqrn yawylaitrr retisvldst rgkqgsqvfr 421 msgrqikely ykvwsnlres ktevlqyfln wdekkcreew eakddtvfve alekvgvfqr 481 lrsmtsaglq gpqyvklqfs rhhrqlrsry elslgmhlrd qlalgvtpsk vphwtaflsm 541 liglfynktf rqkleylleq isevwllphw vdlanvevla adntrvplym lmvavhkeld 601 sddvpdgrfd iillcrdssr evge // LOCUS NP_012092 1758 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012092 VERSION NP_012092.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179522.1 REFERENCE 1 (residues 1 to 1758) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1758) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1758) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1758) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08382. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1758 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1758 /product="Y' element ATP-dependent helicase" /EC_number="3.6.4.12" /calculated_mol_wt="197381" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 676..833 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Region 908..1003 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" Region 1556..>1609 /region_name="YccJ" /note="YccJ-like protein; cl23921" /db_xref="CDD:451607" CDS 1..1758 /locus_tag="YIL177C" /coded_by="NM_001179522.1:1..5277" /note="Putative Y' element ATP-dependent helicase" /db_xref="GeneID:854630" /db_xref="SGD:S000001439" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekvvisvmv gknvkkfltf vedepdfqgg pipskylipk kinlmvytlf 121 qvhtlkfnrk dydtlslfyl nrgyynelsf rvlercheia sarpndsstm rtftdfvsga 181 pivrslqkst irkygynlap ymflllhvde lsifsayqas lpgekkvdte rlkrdlcprk 241 pieikyfsqi cndmmnkkdr lgdilhiilr acalnfgagp rggagdeedr sitneepiip 301 svdehglkvc klrspntprr lrktldavka llvsscacta rdldifddnn gvamwkwiki 361 lyhevaqett lkdsyritlv pssdgislla fagpqrnvyv ddttrriqly tdynkngsse 421 prlktldglt sdyvfyfvtv lrqmqicalg nsydafnhdp wmdvvgfedp nqvtnrdisr 481 ivlysymfln takgclveya tfrqymrelp knapqklnfr emrqglialg rhcvgsrfet 541 dlyesatsel manhsvqtgr niygvdsfsl tsvsgttatl lqeraserwi qwlglesdyh 601 csfsstrnae dvvageaass nhhqkisrvt rkrprepkst ndilvagqkl fgssfefrdl 661 hqlrlcyeiy madtpsvavq appgygktel fhlplialas kgdveyvsfl fvpytvllan 721 cmirlgrcgc lnvapvrnfi eegydgvtdl yvgiyddlas tnftdriaaw enivectfrt 781 nnvklgyliv defhnfetev yrqsqfggit nldfdafeka iflsgtapea vadaalqrig 841 ltglakksmd inelkrsedl srglssyptr mfnlikekse vplghvhkir kkvesqpeea 901 lklllalfes epeskaivva sttneveela cswrkyfrvv wihgklgaae kvsrtkefvt 961 dgsmqvligt klvtegidik qlmmvimldn rlniieliqg vgrlrdgglc yllsrknswa 1021 arnrkgelpp ikegciteqv refygleskk gkkgqhvgcc gsrtdlsadt veliermdrl 1081 aekqatasms ivalpssfqe snssdryrky cssdedsntc ihgsanastn astnaittas 1141 tnvrtnattn astnattnas tnastnattn astnattnss tnatttastn vrtsatttas 1201 invrtsattt estnsstnat ttestnsstn atttestnsn tsatttasin vrtsatttes 1261 tnsstsattt asinvrtsat ttksinsstn atttestnsn tnatttestn sstnatttes 1321 tnsstnattt estnsntsaa ttestnsnts atttestnas akedankdgn aednrfhpvt 1381 dinkesykrk gsqmvllerk klkaqfpnts enmnvlqflg frsdeikhlf lygidiyfcp 1441 egvftqyglc kgcqkmfelc vcwagqkvsy rriawealav ermlrndeey keylediepy 1501 hgdpvgylky fsvkrreiys qiqrnyawyl aitrrretis vldstrgkqg sqvfrmsgrq 1561 ikelyfkvws nlresktevl qyflnwdekk cqeeweakdd tvvvealekg gvfqrlrsmt 1621 saglqgpqyv klqfsrhhrq lrsryelslg mhlrdqialg vtpskvphwt aflsmliglf 1681 ynktfrqkle ylleqisevw llphwldlan vevlaaddtr vplymlmvav hkeldsddvp 1741 dgrfdillcr dssrevge // LOCUS NP_012093 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012093 VERSION NP_012093.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179521.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08383. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..120 /product="seripauperin PAU14" /calculated_mol_wt="12735" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU14" /locus_tag="YIL176C" /coded_by="NM_001179521.1:1..363" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p" /db_xref="GeneID:854631" /db_xref="SGD:S000001438" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ymfqaahpte 61 typvevaeav fnygdfttml tgispdqvtr mitgvpwyss rlkpaissal skdgiytian // LOCUS NP_012095 1549 aa linear PLN 30-JUN-2025 DEFINITION signal sequence-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012095 VERSION NP_012095.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179519.1 REFERENCE 1 (residues 1 to 1549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1549) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08384. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1549 /product="signal sequence-binding protein" /calculated_mol_wt="174298" Region 45..693 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" Region 728..1355 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" CDS 1..1549 /gene="VTH1" /locus_tag="YIL173W" /coded_by="NM_001179519.1:1..4650" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0005048 signal sequence binding [PMID:8662642]" /experiment="EXISTENCE:genetic interaction:GO:0006896 Golgi to vacuole transport [PMID:8662642]" /note="Putative membrane glycoprotein; has strong similarity to Vth2p and Pep1p/Vps10p; may be involved in vacuolar protein sorting" /db_xref="GeneID:854634" /db_xref="SGD:S000001435" ORIGIN 1 malfralyii wvflliplsn aeeftpkvtr tlsryvfdiv nfddsntlir aeedsveisf 61 dagenwktid eieepiesfv vdpfrghdra fafvktapkf yvtddqgksw rpltipisek 121 asnyfcdvtt hpikkkhlii rcdlltikns glmyvgreiy ttndgvsfsq vkpsfgkidg 181 histarcdfi kssedsdlgg ndasilclfr nteyiestgs tidkselils adggetfkel 241 vqfkdkvvsr yeilkhhviv ltqddmynem sstniwisnd vstfqvartp tkirhvnmgq 301 ihedsigriv lpvsrerdde dsnqpgaaev lisdseglkf lpinwipnnq fgyinvaypg 361 flkgtffgsf hpfieysdrk rkysrqkvre etkvsvdngl twtnlkvvdr envdlfgcdv 421 tkpercslqt hfydlrnlnp sagimmisgi vgdgsaynwk eektfisrds gltwrlvhns 481 tglyttgdlg niimyipyrs nengdvpskf yysldqgktw geydlimpiy pyrlvstisd 541 gsgskfiltg tsitedpifi tysidfsavf dyksceegdf edwnladgkc vngakykyrr 601 rkqdaqclvk kafkdlslde tpcnsctgsd yecsfefvrd akgdcipdyn lialsdicdk 661 skgksvlvkp lqlikgdkck tpmkiesvdi pcdeipkegs sdkeivtten kfdfeikfyq 721 yfdtvadesl vmlnsigday ishdggqtik rfdtdgekiv eivfnpyfns saylfgskgn 781 iflthdrgys fmiaklpear qlgmpldfsa kaqdtfiyyg gkncesilsp echavayltk 841 dggetfteml dnaihcefag tlfkypsndd mvmcqvkekf sqtrslvsst dffqddrktv 901 feniigylst ggyiivavph ednelrayvt ndgaefteak fpydedigkq daftilgsee 961 gsiflhlatn lesghdfgnl lksnsngtsf vtlehavnrn tfgyvdfekv qglegiiitn 1021 ivsnsekvge nkedeqlktk itfndgsdwn flkppkkdse gkkfpcdsvs ldkcslhlhg 1081 yterkdirdt yssgsalgmm fgvgnvgdrl lpyeecstfl ttdggetwte vkkgphqwey 1141 gdhggvlvlv penaetdsis ystdfgktwk dykfcgdkvl vkdiitvprd salrfllfge 1201 aknmgsgsfr tytidfrnif erqcefditg rkradfkysp lgsrtgclfg hkteflrktd 1261 ekcfignipl sefsrnvknc pctrqdfecd ynfykasdgt cklvkglssa ngadickkep 1321 dlieyydssg yrkiplstck gglkldahla phpcpgkeka frekysintg ayalvfvtil 1381 lviffvawfv ydrgirrngg fsrfeeirlg ddgliennrt drvvniivrl glcislitks 1441 afqrakagta qlsskfrarf gnkkgatyss llhdqlsdep dgfhedsndl ssfrgqgsns 1501 eieqedvdts qqehtlrtdl lgasnipdal parsashesd laaarsedk // LOCUS NP_012096 589 aa linear PLN 30-JUN-2025 DEFINITION oligo-1,6-glucosidase IMA3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012096 VERSION NP_012096.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179518.1 REFERENCE 1 (residues 1 to 589) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 589) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 589) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 589) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08385. Method: conceptual translation. FEATURES Location/Qualifiers source 1..589 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..589 /product="oligo-1,6-glucosidase IMA3" /EC_number="3.2.1.10" /calculated_mol_wt="68568" Region 16..503 /region_name="AmyAc_SI_OligoGlu_DGase" /note="Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; cd11333" /db_xref="CDD:200472" Site order(30,32,34,38) /site_type="other" /note="Ca binding site [ion binding]" /db_xref="CDD:200472" Site order(69,72,109,112,159,178,182,215,277,442) /site_type="active" /db_xref="CDD:200472" Site order(215,277,352) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:200472" Region 514..585 /region_name="Malt_amylase_C" /note="Maltogenic Amylase, C-terminal domain; pfam16657" /db_xref="CDD:435493" CDS 1..589 /gene="IMA3" /locus_tag="YIL172C" /coded_by="NM_001179518.1:1..1770" /experiment="EXISTENCE:direct assay:GO:0004574 oligo-1,6-glucosidase activity [PMID:20471265]" /experiment="EXISTENCE:direct assay:GO:0004575 sucrose alpha-glucosidase activity [PMID:24649402]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0046352 disaccharide catabolic process [PMID:20471265|PMID:20562106]" /experiment="EXISTENCE:mutant phenotype:GO:0004574 oligo-1,6-glucosidase activity [PMID:20562106]" /note="Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose; lower activitiy and thermostability in vitro than Ima2p despite sequence difference of only 3 amino acids; cleaves alpha-1,3 linkage of nigerose and turanose, but not alpha-1,5 of leucrose; identical to IMA4" /db_xref="GeneID:854635" /db_xref="SGD:S000001434" ORIGIN 1 mtissahpet epkwwkeati yqiypasfkd snndgwgdmk giaskleyik elgtdaiwis 61 pfydspqddm gydianyekv wptygtnedc faliekthkl gmkfitdlvi nhcssehewf 121 kesrssktnp krdwffwrpp kgydaegkpi ppnnwrsyfg gsawtfdekt qefylrlfcs 181 tqpdlnwene dcrkaiyesa vgywldhgvd gfridvgsly skvaglpdap videnskwql 241 sdpftmngpr ihefhqemnk firnrvkdgr eimtvgemrh atdetkrlyt sasrhelsel 301 fnfshtdvgt spkfrqnlip yelkdwkval aelfryvngt dcwstiylen hdqprsitrf 361 gddspknrvi sgkllsvllv slsgtlyvyq gqelgeinfk nwpiekyedv evrnnydaik 421 eehgenskem krfleaiali srdhartpmq wsreepnagf sgpnakpwfy lnesfregin 481 aedeskdpns vlnfwkealr frkahkditv ygydfefidl dnkklfsftk kydnktlfaa 541 lnfssdsidf tipnnsssfk lefgnyprse vdassrtlkp wegriyise // LOCUS NP_012097 995 aa linear PLN 30-JUN-2025 DEFINITION Css1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012097 VERSION NP_012097.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179517.1 REFERENCE 1 (residues 1 to 995) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 995) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 995) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 995) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 995) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 995) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 995) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08386. Method: conceptual translation. FEATURES Location/Qualifiers source 1..995 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..995 /product="Css1p" /calculated_mol_wt="99606" Region 313..596 /region_name="Hyphal_reg_CWP" /note="Hyphally regulated cell wall protein N-terminal; pfam11765" /db_xref="CDD:403079" Region 525..>732 /region_name="Chi1" /note="Chitinase [Carbohydrate transport and metabolism]; COG3469" /db_xref="CDD:442692" Region <618..>941 /region_name="Herpes_BLLF1" /note="Herpes virus major outer envelope glycoprotein (BLLF1); pfam05109" /db_xref="CDD:282904" CDS 1..995 /gene="CSS1" /locus_tag="YIL169C" /gene_synonym="HZY1" /coded_by="NM_001179517.1:1..2988" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Highly variable glycoprotein localized to cell wall via GPI anchor; serine/threonine rich and highly similar to HPF1 haze-protective mannoprotein; necessary and sufficient for haze-positive phenotype in brewing strains which correlates with an expansion in the N-terminal serine-rich region; transcript is induced in both high and low pH environments" /db_xref="GeneID:854637" /db_xref="SGD:S000001431" ORIGIN 1 mfnrlnkfqa alalalysqs algqyysnst sissnsssts vvssssgsvs isssiaetss 61 satdilssit qsasstsgvs ssvgpssssv vsssvsqsss svsdvsssvs qssssasdvs 121 ssvsqsasst sdvsssvsqs sssasdvsss vsqssssasd vsssvsqsas sasdvsssvs 181 qsasstsdvs ssvsqssssa sdvsssvsqs sssasdvsss vsqsasstsd vsssvsqsas 241 stsgvsssgs qsvssasgss ssfpqstssa stasgsatsn slssitssas sasatasnsl 301 sssdgtiylp tttisgdltl tgkviategv vvaagakltl ldgdkysfsa dlkvygdllv 361 kksketypgt efdisgenfd vtgnfnaees aatsasiysf tpssfdnsgd islslskskk 421 gevtfspysn sgafsfsnai lnggsvsglq rrddtegsvn ngeinldngs tyvivepvsg 481 kgtvniisgn lylhypdtft gqtvvfkgeg vlavdptetn atpipvvgyt gknqiaitad 541 italsydgtt gvltatqgnr qfsfaigtgf sssdfsvseg ifagayayyl nyngvvatsa 601 assstasgas asvtgstsfg asvtgstast sfgasvtgst astsfgasvt gstsvytttl 661 dyvnatstvv vscsettdsn gnvytitttv pcssttatit scdetgchvs tstgavvtet 721 vssksyttat vthcddngcn tktvtsecsk etsattaspk syttvtvthc ddngcntktv 781 tseapeattt ttvssqsytt atvthcddng cktktvtsea peattttvsp ktyttatvtq 841 cddngcstkt vtsecpeets atttspksyt tvtvthcddn gcntktvtse apeattttvs 901 pktyttatvt qcddngcstk tvtseapket setsetsaap kdihychwll ngddngcnvk 961 iitskipeat stvtqlvllq shtllsllrv lkqph // LOCUS NP_012100 542 aa linear PLN 30-JUN-2025 DEFINITION Soa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012100 VERSION NP_012100.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179514.1 REFERENCE 1 (residues 1 to 542) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 542) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 542) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 542) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08387. Method: conceptual translation. FEATURES Location/Qualifiers source 1..542 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..542 /product="Soa1p" /calculated_mol_wt="61767" Region 76..496 /region_name="MFS_FEN2_like" /note="Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; cd17327" /db_xref="CDD:340885" Site order(92..93,96..97,100,133,183..184,186..188,191,211, 214..215,218,330,333..334,337..339,342,369,373,425..426, 430,434,451,454..455,458..459,462) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340885" CDS 1..542 /gene="SOA1" /locus_tag="YIL166C" /coded_by="NM_001179514.1:1..1629" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000316 sulfite transmembrane transport [PMID:28165463]" /experiment="EXISTENCE:genetic interaction:GO:1902358 sulfate transmembrane transport [PMID:28165463]" /experiment="EXISTENCE:mutant phenotype:GO:0005342 organic acid transmembrane transporter activity [PMID:28165463]" /experiment="EXISTENCE:mutant phenotype:GO:0008514 organic anion transmembrane transporter activity [PMID:28165463]" /experiment="EXISTENCE:mutant phenotype:GO:0015116 sulfate transmembrane transporter activity [PMID:28165463]" /experiment="EXISTENCE:mutant phenotype:GO:0015711 organic anion transport [PMID:28165463]" /experiment="EXISTENCE:mutant phenotype:GO:0015849 organic acid transport [PMID:28165463]" /experiment="EXISTENCE:mutant phenotype:GO:0071705 nitrogen compound transport [PMID:28165463]" /experiment="EXISTENCE:mutant phenotype:GO:0072337 modified amino acid transport [PMID:28165463]" /experiment="EXISTENCE:mutant phenotype:GO:0072348 sulfur compound transport [PMID:28165463]" /experiment="EXISTENCE:mutant phenotype:GO:1901682 sulfur compound transmembrane transporter activity [PMID:28165463]" /note="Sulfonate and inorganic sulfur transporter; low affinity sulfate, high affinity sulfite, thiosulfite and major sulfonate transporter; functions as a an H+ symporter; similar to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; non-essential gene" /db_xref="GeneID:854640" /db_xref="SGD:S000001428" ORIGIN 1 msvqkeeydi vekaqlsvsa esltsdsesi shnpfddfhk aerwrkvyes sgyeglskfd 61 peftwtkdee kklvrkmdlk iflwvfimfa fldlirknia ravsdnfivd lkmntndynl 121 gqtvylvifl aselpgnlls krfgpervip vqivlwsvic itqaglknrg qfiatrcllg 181 mvqggfipdn ilylsyyytg aeltfrlsff wcaiplfqil gsllasgiie mrgihnlagw 241 qylfiiegfl slsvgvasfy lmrrgptqtg esafhkgksl fteyeekimv nrilrddpsk 301 gdmsnrqpvt fkeilytlte fdlwplfiqg itafislqtv gsylslilks lnystflsni 361 laipgqalll inlplaalls rklkekslcv gianvwvlpf ivslvalptd tnpwikyill 421 tgilglpyth silagwvsei snsvrsrtvg talynmsaqv gaiiasnmyr nddkpyytrg 481 nkillgftcf nicmavatkf yyisrnkykd rkwnsmtkee qinyldttkd kgmkrldyrf 541 ih // LOCUS NP_012101 119 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL165C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012101 VERSION NP_012101.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179513.1 REFERENCE 1 (residues 1 to 119) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 119) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 119) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 119) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08388. Method: conceptual translation. FEATURES Location/Qualifiers source 1..119 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..119 /product="uncharacterized protein" /calculated_mol_wt="12809" Region <1..110 /region_name="nitrilase" /note="Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; cl11424" /db_xref="CDD:448250" CDS 1..119 /locus_tag="YIL165C" /coded_by="NM_001179513.1:1..360" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /note="hypothetical protein; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene" /db_xref="GeneID:854641" /db_xref="SGD:S000001427" ORIGIN 1 mkniayegrl flisavqfmp datamgfgei idqatgkrkl pgwpsaddnc inggsviidp 61 ygeiiagpll gqeglltaei ntdliaearf dldpvghyar gdvfqltvne rshdvkftk // LOCUS NP_012102 199 aa linear PLN 30-JUN-2025 DEFINITION Nit1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012102 VERSION NP_012102.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179512.1 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08389. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..199 /product="Nit1p" /calculated_mol_wt="21489" Region 4..>198 /region_name="nitrilase" /note="Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; cl11424" /db_xref="CDD:448250" Site order(44,135,139,142,169..170,172..173,193) /site_type="active" /db_xref="CDD:143588" Site order(44,135,169) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:143588" CDS 1..199 /gene="NIT1" /locus_tag="YIL164C" /coded_by="NM_001179512.1:1..600" /note="Nitrilase; member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene" /db_xref="GeneID:854642" /db_xref="SGD:S000001426" ORIGIN 1 makhivaalq igscpgstkd tlkkilsyek eikesgaklv vipeatlggy pkgsnfgvyl 61 gyrlqegree yakylaeaie igngekypei sqlcalskat daslcvgcie rdgttlyctm 121 vyidpkdgyv gkhrklmpta gerliwgqgd gstlpvvdta agkiggaicw enmmpllrya 181 mykkgveiwc aptvdarpi // LOCUS NP_001257678 117 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL163C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257678 VERSION NP_001257678.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270749.1 REFERENCE 1 (residues 1 to 117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 117) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35116. Method: conceptual translation. FEATURES Location/Qualifiers source 1..117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..117 /product="uncharacterized protein" /calculated_mol_wt="13858" CDS 1..117 /locus_tag="YIL163C" /coded_by="NM_001270749.1:1..354" /note="hypothetical protein; mRNA identified as translated by ribosome profiling data" /db_xref="GeneID:854643" /db_xref="SGD:S000001425" ORIGIN 1 mflfrrkdyr ieiqkkkvvk sffqmvyyra lrqhfcqtks fkhsskrnvs mmvigkhray 61 lkslrhhikg fiitflvsfs rnlhgktldv gsinatriss ppdnflnwvf sfyscse // LOCUS NP_012104 532 aa linear PLN 30-JUN-2025 DEFINITION beta-fructofuranosidase SUC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012104 VERSION NP_012104.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179510.1 REFERENCE 1 (residues 1 to 532) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 532) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 532) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 532) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08390. Method: conceptual translation. FEATURES Location/Qualifiers source 1..532 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..532 /product="beta-fructofuranosidase SUC2" /EC_number="3.2.1.26" /calculated_mol_wt="60508" Region 37..334 /region_name="GH32_Inu-like" /note="glycoside hydrolase family 32 protein such as Aspergillus ficuum endo-inulinase (Inu2); cd18622" /db_xref="CDD:350134" Site order(41..42,60,102,170,223,311) /site_type="other" /note="chemical substrate binding site [chemical binding]" /db_xref="CDD:350134" Site order(285..286,308,326..328,330) /site_type="other" /note="beta-sandwich domain interface [polypeptide binding]" /db_xref="CDD:350134" Region 368..501 /region_name="Glyco_hydro_32C" /note="Glycosyl hydrolases family 32 C terminal; pfam08244" /db_xref="CDD:462408" CDS 1..532 /gene="SUC2" /locus_tag="YIL162W" /coded_by="NM_001179510.1:1..1599" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004564 beta-fructofuranosidase activity [PMID:363706|PMID:3902817]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:6341817]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:6341817]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005987 sucrose catabolic process [PMID:363706|PMID:3902817]" /experiment="EXISTENCE:direct assay:GO:0051670 inulinase activity [PMID:23104410]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1902927 inulin catabolic process [PMID:23104410]" /experiment="EXISTENCE:mutant phenotype:GO:0004564 beta-fructofuranosidase activity [PMID:2834091]" /experiment="EXISTENCE:mutant phenotype:GO:0005987 sucrose catabolic process [PMID:2834091]" /experiment="EXISTENCE:mutant phenotype:GO:0010147 fructan catabolic process [PMID:23339519]" /experiment="EXISTENCE:mutant phenotype:GO:0034484 raffinose catabolic process [PMID:23339519]" /note="Invertase; sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively" /db_xref="GeneID:854644" /db_xref="SGD:S000001424" ORIGIN 1 mllqaflfll agfaakisas mtnetsdrpl vhftpnkgwm ndpnglwyde kdakwhlyfq 61 ynpndtvwgt plfwghatsd dltnwedqpi aiapkrndsg afsgsmvvdy nntsgffndt 121 idprqrcvai wtyntpesee qyisysldgg ytfteyqknp vlaanstqfr dpkvfwyeps 181 qkwimtaaks qdykieiyss ddlkswkles afanegflgy qyecpgliev pteqdpsksy 241 wvmfisinpg apaggsfnqy fvgsfngthf eafdnqsrvv dfgkdyyalq tffntdptyg 301 salgiawasn weysafvptn pwrssmslvr kfslnteyqa npetelinlk aepilnisna 361 gpwsrfatnt tltkansynv dlsnstgtle felvyavntt qtisksvfad lslwfkgled 421 peeylrmgfe vsassffldr gnskvkfvke npyftnrmsv nnqpfksend lsyykvygll 481 dqnilelyfn dgdvvstnty fmttgnalgs vnmttgvdnl fyidkfqvre vk // LOCUS NP_012105 235 aa linear PLN 30-JUN-2025 DEFINITION Smu2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012105 VERSION NP_012105.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179509.1 REFERENCE 1 (residues 1 to 235) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 235) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 235) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08391. Method: conceptual translation. FEATURES Location/Qualifiers source 1..235 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..235 /product="Smu2p" /calculated_mol_wt="26981" CDS 1..235 /gene="SMU2" /locus_tag="YIL161W" /coded_by="NM_001179509.1:1..708" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:36113412]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:36113412]" /experiment="EXISTENCE:direct assay:GO:0070651 nonfunctional rRNA decay [PMID:36113412]" /note="Protein involved in removal of stalled, decoding-defective ribosomes; acts as cofactor for Fap1p, along with Fpr1p, increasing the efficiency of Rps3p polyubiquitination on stalled monosomes and the subsequent decay of nonfunctional 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; non-essential gene" /db_xref="GeneID:854645" /db_xref="SGD:S000001423" ORIGIN 1 mdtklsvtga kksqgkasgl gnegtpigne estnkakngn kkrnknrnrn kktetkeqne 61 pkpvtggeev rveksqaknr rrknnngank kntlhyskei nveerkqiak rqeeieqcih 121 tlsdfklfkk gkhvtsygyr ispmtdsgki slkilfnipl dypkapiklt mksneevssy 181 mdtvianfnw karqlvkedw rilsqinylv seleilkmen ykqidklrns fykti // LOCUS NP_012106 417 aa linear PLN 30-JUN-2025 DEFINITION acetyl-CoA C-acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012106 VERSION NP_012106.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179508.1 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08392. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..417 /product="acetyl-CoA C-acyltransferase" /EC_number="2.3.1.16" /calculated_mol_wt="44599" Region 37..414 /region_name="thiolase" /note="Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; cd00751" /db_xref="CDD:238383" Site order(56,87,101,104,108,119..122,130,137..138,141,156,305, 307,309,329,406..407) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238383" Site order(125,375,403) /site_type="active" /db_xref="CDD:238383" CDS 1..417 /gene="POT1" /locus_tag="YIL160C" /gene_synonym="FOX3; POX3" /coded_by="NM_001179508.1:1..1254" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0003988 acetyl-CoA C-acyltransferase activity [PMID:7754706]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:19470242]" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:8125978|PMID:7754706]" /experiment="EXISTENCE:mutant phenotype:GO:0005782 peroxisomal matrix [PMID:8125978]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:12819196]" /note="3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids" /db_xref="GeneID:854646" /db_xref="SGD:S000001422" ORIGIN 1 msqrlqsikd hlvesamgkg eskrknslle krpedvviva anrsaigkgf kgafkdvntd 61 yllynflnef igrfpeplra dlnlieevac gnvlnvgaga tehraaclas gipystpfva 121 lnrqcssglt avndiankik vgqidiglal gvesmtnnyk nvnplgmiss eelqknreak 181 kclipmgitn envaanfkis rkdqdefaan syqkaykakn eglfedeilp iklpdgsicq 241 sdegprpnvt aeslssirpa fikdrgttta gnasqvsdgv agvllarrsv anqlnlpvlg 301 ryidfqtvgv ppeimgvgpa yaipkvleat glqvqdidif eineafaaqa lycihklgid 361 lnkvnprgga ialghplgct garqvatilr elkkdqigvv smcigtgmga aaifike // LOCUS NP_012107 1375 aa linear PLN 30-JUN-2025 DEFINITION formin BNR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012107 VERSION NP_012107.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179507.1 REFERENCE 1 (residues 1 to 1375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1375) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08393. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1375 /product="formin BNR1" /calculated_mol_wt="156722" Region 510..>603 /region_name="EnvC" /note="Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]; COG4942" /db_xref="CDD:443969" Region 868..1265 /region_name="FH2" /note="Formin Homology 2 Domain; pfam02181" /db_xref="CDD:396655" CDS 1..1375 /gene="BNR1" /locus_tag="YIL159W" /coded_by="NM_001179507.1:1..4128" /experiment="EXISTENCE:direct assay:GO:0005522 profilin binding [PMID:15923184]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:38656798]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9774458|PMID:38656798]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:26771880]" /experiment="EXISTENCE:direct assay:GO:0045010 actin nucleation [PMID:30076201]" /experiment="EXISTENCE:direct assay:GO:0051016 barbed-end actin filament capping [PMID:15923184]" /experiment="EXISTENCE:direct assay:GO:0051017 actin filament bundle assembly [PMID:15923184]" /experiment="EXISTENCE:direct assay:GO:0070649 formin-nucleated actin cable assembly [PMID:15923184]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:17237521]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:23671312]" /experiment="EXISTENCE:genetic interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:11740491]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:17237521]" /experiment="EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:12419188]" /experiment="EXISTENCE:mutant phenotype:GO:0005522 profilin binding [PMID:15923184]" /experiment="EXISTENCE:mutant phenotype:GO:0051017 actin filament bundle assembly [PMID:23671312]" /experiment="EXISTENCE:mutant phenotype:GO:0070649 formin-nucleated actin cable assembly [PMID:15371545]" /note="Formin; nucleates the formation of linear actin filaments; involved in processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables; activity is regulated by Hof1p and by the Bud14p-Kel1p-Kel2p complex; dephosphorylated and delocalized from the division site in a Glc7p/Ref2p-dependent manner; functionally redundant with BNI1" /db_xref="GeneID:854647" /db_xref="SGD:S000001421" ORIGIN 1 mdsspnkkty ryprrslslh ardrvseark leelnlndgl vaaglqlvgv alekqgtgsh 61 iymkqknfsa ndvssspmvs eevngsemdf npkcmpqdas lvermfdell kdgtffwgaa 121 yknlqnislr rkwllickir ssnhwgkkkv tssttysthl atnelaenah fldglvrnls 181 tggmklskal yklekflrkq sflqlflkde iylttliekt lpliskelqf vylrcfkilm 241 nnplariral hseplirwft elltdqnsnl kcqllsmell llltyvegst gceliwdqls 301 ilftdwlewf dkiladdiai hsslylnwnq lkidysttfl llinsilqgf nnktaleiln 361 flkknnihnt itflelaykd dpnsvvimeq ikqfkskesa ifdsmikttn dtnslhptkd 421 iarieseplc lenclllkak dspveapine iiqslwkild sqkpysesik llklinsllf 481 ylidsfqvst npsfdetles aenvdyvfqd svnklldslq sdeiarravt eiddlnakis 541 hlneklnlve nhdkdhliak ldeseslisl ktkeienlkl qlkatkkrld qitthqrlyd 601 qppslassnl siagsiiknn shgniifqnl akkqqqqqki slpkrstsll kskrvtslss 661 yltdannene sqnesedksk dslfqrstst infnipsmkn itnmqnvsln silselefsn 721 slgtqpnyqs spvlssvsss pklfprlssd sldngiqlvp evvklpqlpp pppppppppl 781 pqsllteaea kpdgvsciaa pappplpdlf ktktcgavpp pppppplpes lsmnkgpsnh 841 dlvtppappl pngllssssv sinptttdlk ppptekrlkq ihwdkvedik dtlwedtfqr 901 qetikelqtd gifsqiedif kmksptkian krnaessial ssnngkssne lkkisflsrd 961 laqqfginlh mfsqlsdmef vmkvlncdnd ivqnvnilkf fckeelvnip ksmlnkyepy 1021 sqgkdgkavs dlqradrifl elcinlrfyw narskslltl styerdyydl ifklqkidda 1081 ishlnrspkf kslmfiitei gnhmnkrivk giklksltkl afvrssidqn vsflhfiekv 1141 irikypdiyg fvddlknied lgkislehve sechefhkki edlvtqfqvg klskeenldp 1201 rdqiikkvkf kinraktkse lligqckltl idlnklmkyy gedpkdkesk neffqpfief 1261 lamfkkcake niekeemerv yeqrkslldm rtssnkksng sdendgekvn rdavdllisk 1321 lrevkkdpep lrrrkstkln eiainvhegd vktrkdedhv llerthamln diqni // LOCUS NP_012108 204 aa linear PLN 30-JUN-2025 DEFINITION Aim20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012108 VERSION NP_012108.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179506.3 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08394. On Jul 30, 2012 this sequence version replaced NP_012108.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..204 /product="Aim20p" /calculated_mol_wt="22709" Region 5..>43 /region_name="SKG6" /note="SKG6 family; pfam08693" /db_xref="CDD:462564" CDS 1..204 /gene="AIM20" /locus_tag="YIL158W" /coded_by="NM_001179506.3:1..615" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /note="hypothetical protein; overexpression causes cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to vacuole; null mutant displays elevated frequency of mitochondrial genome loss; relocalizes from nucleus to cytoplasm upon DNA replication stress; AIM20 has a paralog, SKG1, that arose from the whole genome duplication" /db_xref="GeneID:854648" /db_xref="SGD:S000001420" ORIGIN 1 mgnvsvavgt avgipiavgv iialifwckl qrrykkeeir dadlekmvme evavsvydgf 61 kaeinsssea stinekeanq dlkpcqekta kagytpayrr qlnasmgtlr pkkqstaytn 121 vpvifsgekv nygmvrdpsy sfmypltlsr ketsslrsas tsnlsssten talheeikld 181 dpyendftny tvnkrefids lrph // LOCUS NP_012109 197 aa linear PLN 30-JUN-2025 DEFINITION Coa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012109 VERSION NP_012109.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179505.1 REFERENCE 1 (residues 1 to 197) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 197) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 197) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08395. Method: conceptual translation. FEATURES Location/Qualifiers source 1..197 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..197 /product="Coa1p" /calculated_mol_wt="21913" Region 74..189 /region_name="Coa1" /note="Cytochrome oxidase complex assembly protein 1; pfam08695" /db_xref="CDD:430157" CDS 1..197 /gene="COA1" /locus_tag="YIL157C" /coded_by="NM_001179505.1:1..594" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:17882259]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:17882260]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:17882260|PMID:17882259]" /experiment="EXISTENCE:physical interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:17882259]" /note="Mitochondrial inner membrane protein; required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly" /db_xref="GeneID:854649" /db_xref="SGD:S000001419" ORIGIN 1 mmlrlvtkgl pkvtpsaaka vlvrgsllhs fstsarfnns vaedeakivl kdknrplrid 61 relpdptter rkriagfllf svaigsalsl ifnyektesp iisntlyyir rspatknilg 121 esiefdgiip wvygelnsvk grinitfyik gdknvtgtvr lvadrnthde eflihewsvt 181 aagqkidlla entktpi // LOCUS NP_001027534 73 aa linear PLN 30-JUN-2025 DEFINITION mitofissin [Saccharomyces cerevisiae S288C]. ACCESSION NP_001027534 VERSION NP_001027534.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184521.1 REFERENCE 1 (residues 1 to 73) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 73) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 73) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 73) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08396. Method: conceptual translation. FEATURES Location/Qualifiers source 1..73 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..73 /product="mitofissin" /calculated_mol_wt="8033" Region 4..72 /region_name="DUF1748" /note="Fungal protein of unknown function (DUF1748); pfam08520" /db_xref="CDD:430050" CDS 1..73 /gene="ATG44" /locus_tag="YIL156W-B" /gene_synonym="MCO8; MDI1" /coded_by="NM_001184521.1:1..222" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:37192628]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:37192628]" /experiment="EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:37192628]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:37192628]" /note="Mitochondrial fission factor (mitofissin) essential for mitophagy; required for Dmn1p-mediated mitochondrial fission; directly binds to lipid membranes and brings about lipid membrane fragility to facilitate membrane fission; S. pombe homolog complements null mutant" /db_xref="GeneID:3628034" /db_xref="SGD:S000028511" ORIGIN 1 mtlvgklvhi sidlvlvstc lagikrntgl tpkletldnq tmrnymkryl nlgesvydys 61 vatcgsstyf ark // LOCUS NP_012110 1071 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease UBP7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012110 VERSION NP_012110.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179504.1 REFERENCE 1 (residues 1 to 1071) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1071) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1071) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1071) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08397. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1071 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1071 /product="ubiquitin-specific protease UBP7" /EC_number="3.4.19.12" /calculated_mol_wt="123003" Region 328..443 /region_name="RHOD" /note="Rhodanese Homology Domain; smart00450" /db_xref="CDD:197731" Region 609..1066 /region_name="UCH" /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443" /db_xref="CDD:425685" Site order(613,618,1014,1039) /site_type="active" /db_xref="CDD:239139" CDS 1..1071 /gene="UBP7" /locus_tag="YIL156W" /coded_by="NM_001179504.1:1..3216" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:8982460]" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:24746795]" /experiment="EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:24746795]" /note="Ubiquitin-specific protease that cleaves ubiquitin-protein fusions; involved in cell cycle progression through S phase; UBP7 has a paralog, UBP11, that arose from the whole genome duplication" /db_xref="GeneID:854650" /db_xref="SGD:S000001418" ORIGIN 1 mldddkgtam hphitpftpe ysnellrrvq dlyhedikhy ypqlklekll dllehteylf 61 elyldsihhd rpndaltafi igcyyvflii pqslqfqtrn ksysiytdlk kmyenemnmt 121 nvvlmvkkei gvvldesvkh gagiehritk krafsvpadd lsgqvaslsl dtaapqdhgl 181 kgtfteddae qsspvwtapn lepndqlkla llpeviptpa freperktsv pvrpsvlled 241 vpsiyheddt sfaslnppfr eitadrsvth rkdsyhsvym vdsgnlkedn ddlfnvendg 301 fiqsldilqk qsiitapelf silsnrvere kvllidlrip qrsainhiva pnlvnvdpnl 361 lwdkqtntpi ykddilehll kenenfinrn kfdyivyytd vktfmtinfd yafiffylml 421 tsqktplttv pttllggyek wkktlhsyaq eyhisiedyl yrpysqkarl qqeqqqqqqq 481 pdsqdsfsak esstkvpepp swkppdlpir lrkrpppppp vsmpttpeip pplppkimvh 541 sqvssisrkp pipakqhvkk eqlnsneiiq rkrqhqhqhy dqqilqpqra yniptiersp 601 nvyvslsitg lrnlgntcyi nsmiqclfaa ktfrtlfiss kyksylqpir sngshyspkl 661 snslsmlfnk mylnggcsvv ptgflkvinq lrpdlkipdd qqdtqeflmi lldrlhdels 721 dqqhvandyp nlllynadal kvsnneykhw fdknvigngi spiddifqgq menslqckrc 781 gyttfnystf yvlslaiprr smklsklgrs tekrvkledc inmftsdevl sgenawdcpr 841 cgptasvsts vsalenepsi vkskkkksrf ftlhtgtkrr hldffgdgit eghnsnnnnt 901 tiferersrs pfrmlggsgk rsssstpfst ggndsnnssd yknkklttvk tinfvtlpki 961 lvihlsrfyy dltkknntvv typlilniil knndtmkykl fgvvnhtgtl isghytslvn 1021 kdlehnvnig rskwyyfdde vvkadrkhgs dknlkisssd vyvlfyervy d // LOCUS NP_012111 649 aa linear PLN 30-JUN-2025 DEFINITION glycerol-3-phosphate dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012111 VERSION NP_012111.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179503.1 REFERENCE 1 (residues 1 to 649) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 649) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 649) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 649) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08398. Method: conceptual translation. FEATURES Location/Qualifiers source 1..649 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..649 /product="glycerol-3-phosphate dehydrogenase" /EC_number="1.1.5.3" /calculated_mol_wt="72258" Region 28..647 /region_name="DAO" /note="FAD dependent oxidoreductase; cl40741" /db_xref="CDD:477422" CDS 1..649 /gene="GUT2" /locus_tag="YIL155C" /coded_by="NM_001179503.1:1..1950" /experiment="EXISTENCE:direct assay:GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity [PMID:12032156]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936]" /experiment="EXISTENCE:mutant phenotype:GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity [PMID:8256521]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:8256521]" /experiment="EXISTENCE:mutant phenotype:GO:0006071 glycerol metabolic process [PMID:8256521]" /note="Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner" /db_xref="GeneID:854651" /db_xref="SGD:S000001417" ORIGIN 1 mfsvtrrraa gaaaamatat gtlywmtsqg drplvhndps ymvqfptaap pqvsrrdlld 61 rlakthqfdv liigggatgt gcaldaatrg lnvalvekgd fasgtsskst kmihggvryl 121 ekafwefska qldlviealn erkhlintap hlctvlpili piystwqvpy iymgckfydf 181 fagsqnlkks yllsksatve kapmlttdnl kaslvyhdgs fndsrlnatl aitavengat 241 vlnyvevqkl ikdptsgkvi gaeardvetn elvrinakcv vnatgpysda ilqmdrnpsg 301 lpdsplndns kikstfnqia vmdpkmvips igvhivlpsf ycpkdmglld vrtsdgrvmf 361 flpwqgkvla gttdiplkqv penpmptead iqdilkelqh yiefpvkred vlsawagvrp 421 lvrdprtipa dgkkgsatqg vvrshflfts dnglitiagg kwttyrqmae etvdkvvevg 481 gfhnlkpcht rdiklagaee wtqnyvalla qnyhlsskms nylvqnygtr ssiiceffke 541 smenklplsl adkennviys seennlvnfd tfrypftige lkysmqyeyc rtpldfllrr 601 trfafldake alnavhatvk vmgdefnwse kkrqwelekt vnfiktfgv // LOCUS NP_012112 346 aa linear PLN 30-JUN-2025 DEFINITION Imp21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012112 VERSION NP_012112.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179502.3 REFERENCE 1 (residues 1 to 346) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 346) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 346) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 346) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08399. On Jul 30, 2012 this sequence version replaced NP_012112.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..346 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..346 /product="Imp21p" /calculated_mol_wt="38940" CDS 1..346 /gene="IMP21" /locus_tag="YIL154C" /gene_synonym="IMP2" /coded_by="NM_001179502.3:1..1041" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:8628275]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:7496532]" /note="Transcriptional activator involved in maintenance of ion homeostasis; also involved in protection against DNA damage caused by bleomycin and other oxidants; contains a C-terminal leucine-rich repeat" /db_xref="GeneID:854652" /db_xref="SGD:S000001416" ORIGIN 1 mqksilltkp dgtqsnlhsi ktetpttvef dseqmerghr ergrskkkrg erdsnvssls 61 rsrsrassrs rvreeeflkw tvlrqdpsmr lrvvdvdsee egegndeddd dgdgddmdee 121 esdeeqvsdi endleideef hydlgmkvlp nfctsinevl dsskpwiaky eisirghene 181 dvsleqldgg yvramqlltk gagaeagnqr sfilytdlss estyaltylm gaavnqgdtv 241 yivhwepskp tddsqmfanv arirkhvmhl fdcvagvldd ldvvvlslth pypkhllnem 301 ihglkpvalc cslsvilstl qnfvcsvpil avrkklkrak rkgise // LOCUS NP_012113 393 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase RRD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012113 VERSION NP_012113.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179501.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08400. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..393 /product="peptidylprolyl isomerase RRD1" /EC_number="5.2.1.8" /calculated_mol_wt="44951" Region 1..387 /region_name="LAG1" /note="Phosphotyrosyl phosphatase activator [Cell division and chromosome partitioning / Signal transduction mechanisms]; COG5057" /db_xref="CDD:227390" Site order(87,95,141,192..193,195,198..199,201,207,258,260..261, 265,303) /site_type="other" /note="peptide-induced dimer interface [polypeptide binding]" /db_xref="CDD:239754" Site order(141,143,145..148,195..196,205..207,209,273,277,283, 287,290,294,298,300..301,303..304) /site_type="active" /note="putative interaction site [active]" /db_xref="CDD:239754" Site order(141,143,145..148,196..198,300..301,303..304) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:239754" Site order(201..202,268..269,272..273,277,286..287,297..300) /site_type="active" /note="peptide binding pocket [active]" /db_xref="CDD:239754" Site order(201,265,277,286,290,298) /site_type="other" /note="putative PP2A binding surface [polypeptide binding]" /db_xref="CDD:239754" CDS 1..393 /gene="RRD1" /locus_tag="YIL153W" /gene_synonym="YPA1" /coded_by="NM_001179501.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:21129186]" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:16380387]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15150670]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15150670]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:9705277|PMID:15150670]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:21129186]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:31962153]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:11262194]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:12952889]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:21129186]" /experiment="EXISTENCE:physical interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:11134337]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:21129186]" /experiment="EXISTENCE:physical interaction:GO:0033554 cellular response to stress [PMID:21129186]" /note="Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to rapamycin; subunit of the Tap42p-Sit4p-Rrd1p complex; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:854653" /db_xref="SGD:S000001415" ORIGIN 1 msldrvdwph atfstpvkri fdtqttldfq sslaihriky hlhkyttlis hcsdpdphat 61 assiamvngl mgvldklahl idetpplpgp rrygnlacre whhklderlp qwlqemlpse 121 yhevvpelqy ylgnsfgsst rldygtghel sfmatvaald mlgmfphmrg advfllfnky 181 ytimrrlilt ytlepagshg vwglddhfhl vyilgssqwq lldaqaplqp reildkslvr 241 eykdtnfycq ginfinevkm gpfeehspil ydiavtvprw skvckgllkm ysvevlkkfp 301 vvqhfwfgtg ffpwvniqng tdlpvfeeke eesieqanag spgreqtstr fptstsmppp 361 gvppsgnnin yllshqnqsh rnqtsfsrdr lrr // LOCUS NP_012114 235 aa linear PLN 30-JUN-2025 DEFINITION Vpr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012114 VERSION NP_012114.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179500.1 REFERENCE 1 (residues 1 to 235) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 235) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 235) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08401. Method: conceptual translation. FEATURES Location/Qualifiers source 1..235 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..235 /product="Vpr1p" /calculated_mol_wt="27070" CDS 1..235 /gene="VPR1" /locus_tag="YIL152W" /coded_by="NM_001179500.1:1..708" /note="hypothetical protein" /db_xref="GeneID:854654" /db_xref="SGD:S000001414" ORIGIN 1 mshkrrglvi yqdqkqqqqh ppgqslssis wsptrrphhp lkqqstnsfs eilskssvqp 61 nvqhdgnhmp isllvlkqeh hkqqqqqqqr qnirsqnstp plrqlvqesq wtssasnssl 121 kkqekqpqtf yntdsklvsq lhssvkdlda iiqthkpkfd tiirdfsqat ilssnellik 181 lpkdqtiilh srapkinaew lqnkvndpsa slvidsrsfl tlcnnikwyl hwkfi // LOCUS NP_012115 1118 aa linear PLN 30-JUN-2025 DEFINITION Esl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012115 VERSION NP_012115.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179499.1 REFERENCE 1 (residues 1 to 1118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1118) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08402. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1118 /product="Esl1p" /calculated_mol_wt="128604" Region 949..1090 /region_name="PIN_SF" /note="PIN (PilT N terminus) domain: Superfamily; cl28905" /db_xref="CDD:475124" CDS 1..1118 /gene="ESL1" /locus_tag="YIL151C" /coded_by="NM_001179499.1:1..3357" /note="hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl1p and Esl2p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; ESL1 has a paralog, ESL2, that arose from the whole genome duplication" /db_xref="GeneID:854655" /db_xref="SGD:S000001413" ORIGIN 1 mvdlmvpand dpsnetdysr snnnhthivs dmrptsaafl hqkrhssssh ndtpessfak 61 rrvpgivdpv gkgfidgitn sqisaqntps ktddasrrps isrkvmestp qvktssiptm 121 dvpkspyyvn rtmlarnmkv vsrdtyedna npqmradepl vasngiysns qpqsqvtlsd 181 irrapvvaas pppmirqlps aqpnqtfikk lqeiykiivv qetelqqrcl ylttsqttel 241 kslwaiyrln teliknyinf iitallttqp indlimgqei ldiyriekrl wvygiitfld 301 vlknfsnfmd pevccqfiiy afisvsnmle diplkysilw rqrlgdlsrm aislypsgfi 361 dwrlsaeywy tesmkyiygc gklyyhiatv qqnsleafvn lgksvfcqdp ftpsqqtlql 421 lieniyqsaf idrssgsann neiahrnsql idylkhtevm llpsflenmd lqhvvlmyfk 481 dkfgkdfngn dvfdtkdmfc qnpeslryyf rhapafaesq llqligfgnp knpfallfql 541 pkylklkkdk rekkrseate tssytdpfdv qissesyfqn idalnssfnd iptnlniwld 601 slnhinmtsi qcsihvltkf lhaplvvalp hfltwlhfiv ailkklemvn skqvvafwih 661 flrrtmpwns ivtlgnvlvc ymldnlhpfl kkelekfysl elddlieyyn enenlpeiwk 721 cwgtlwfdai kkcdvmeipg vqdhlffdsp ldgivfdekd evgekfwmrs vravlllkgi 781 akkfpdlglk vsfqasvfcr rndippdyfl knltfklday dednyndnne lddlydtiei 841 neeieavnmd pqatpnlsvv sgesifeytg ytrlapdyhc fdknggfnsa fiysqwsnvg 901 ngvtldvsge siydvannnl slhwekiffd kiaaaskgsd enynctlyfv idatswlrhf 961 ahifklaknn tlkfaicltt fqelrylrgs kddtvveaat rsvitirqly dekkiipmrf 1021 tgniathvee nlefeeqitw kthvdefvid aiaklnqrfq aerltdenkn kgkefavlvt 1081 dddnmnqkak drmiktcntk ylfslgsklg insglctn // LOCUS NP_012116 571 aa linear PLN 30-JUN-2025 DEFINITION Mcm10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012116 VERSION NP_012116.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179498.1 REFERENCE 1 (residues 1 to 571) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 571) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 571) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 571) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08403. Method: conceptual translation. FEATURES Location/Qualifiers source 1..571 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..571 /product="Mcm10p" /calculated_mol_wt="65684" Region 301..347 /region_name="zf-primase" /note="Primase zinc finger; pfam09329" /db_xref="CDD:462758" CDS 1..571 /gene="MCM10" /locus_tag="YIL150C" /gene_synonym="DNA43" /coded_by="NM_001179498.1:1..1716" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:15494305|PMID:10783164]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:19605346]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:27751725|PMID:19605346]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9154825|PMID:11168584|PMID:13680157]" /experiment="EXISTENCE:direct assay:GO:1902969 mitotic DNA replication [PMID:38109526]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:10783164]" /experiment="EXISTENCE:genetic interaction:GO:0006271 DNA strand elongation involved in DNA replication [PMID:10783164|PMID:11168584]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0005657 replication fork [PMID:15494305]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:10783164|PMID:9154825]" /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:11168584|PMID:10783164|PMID:9154825]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16328881|PMID:16085704]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16085704]" /note="Essential chromatin-associated protein; involved in initiation of DNA replication; promotes origin duplex unwinding by head-to-head CMG helicase complexes; required for association of MCM2-7 complex with replication origins; required to stabilize the catalytic subunit of DNA polymerase-alpha; coordinates function of the replication fork helicase; self-associates through its N-terminal domain" /db_xref="GeneID:854656" /db_xref="SGD:S000001412" ORIGIN 1 mndpreilav dpynnitsde edeqaiarel efmerkrqal verlkrkqef kkpqdpnfea 61 ievpqsptkn rvkvgshnat qqgtkfegsn inevrlsqlq qqpkppastt tyfmekfqna 121 kknedkqiak fesmmnarvh tfstdekkyv piitnelesf snlwvkkryi peddlkralh 181 eikilrlgkl fakirppkfq epeyanwatv glishksdik ftssekpvkf fmftitdfqh 241 tldvyifgkk gveryynlrl gdviailnpe vlpwrpsgrg nfiksfnlri shdfkcilei 301 gssrdlgwcp ivnkkthkkc gspinislhk ccdyhrevqf rgtsakriel nggyalgapt 361 kvdsqpslyk akgengfnii kgtrkrlsee eerlkksshn ftnsnsakaf fdekfqnpdm 421 lanldnkrrk iietkkstal srelgkimrr ressgledks vgerqkmkrt tesalqtgli 481 qrlgfdpthg kisqvlkssv sgsepknnll gkkktvindl lhykkekvil apsknewfkk 541 rshreevwqk hfgsketket sdgsasdlei i // LOCUS NP_012117 1679 aa linear PLN 30-JUN-2025 DEFINITION Mlp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012117 VERSION NP_012117.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179497.3 REFERENCE 1 (residues 1 to 1679) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1679) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1679) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1679) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08404. On Jul 30, 2012 this sequence version replaced NP_012117.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1679 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1679 /product="Mlp2p" /calculated_mol_wt="195011" Region 59..988 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 651..1435 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region <1309..1670 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" CDS 1..1679 /gene="MLP2" /locus_tag="YIL149C" /coded_by="NM_001179497.3:1..5040" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:10085285]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:10085285]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:24152732]" /experiment="EXISTENCE:genetic interaction:GO:0006355 regulation of DNA-templated transcription [PMID:15692572]" /experiment="EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:10085285]" /experiment="EXISTENCE:genetic interaction:GO:0034398 telomere tethering at nuclear periphery [PMID:10638763]" /experiment="EXISTENCE:genetic interaction:GO:0043021 ribonucleoprotein complex binding [PMID:15692572]" /experiment="EXISTENCE:genetic interaction:GO:1901925 negative regulation of protein import into nucleus during spindle assembly checkpoint [PMID:23177738]" /experiment="EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:21036941]" /experiment="EXISTENCE:mutant phenotype:GO:0051300 spindle pole body organization [PMID:16027220]" /experiment="EXISTENCE:physical interaction:GO:0005816 spindle pole body [PMID:16027220]" /experiment="EXISTENCE:physical interaction:GO:0043021 ribonucleoprotein complex binding [PMID:15692572]" /note="Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length; MLP2 has a paralog, MLP1, that arose from the whole genome duplication" /db_xref="GeneID:854657" /db_xref="SGD:S000001411" ORIGIN 1 medkisefln vpfeslqgvt ypvlrklykk iakferseee vtklnvlvde iksqyysris 61 klkqlldess eqkntakeel nglkdqlnee rsryrreida lkkqlhvshe amrevndekr 121 vkeeydiwqs rdqgndslnd dlnkenkllr rklmemenil qrcksnaisl qlkydtsvqe 181 kelmlqskkl ieeklssfsk ktlteevtks shvenleekl yqmqsnyesv ftynkfllnq 241 nkqlsqsvee kvlemknlkd tasvekaefs kemtlqknmn dllrsqltsl ekdcslraie 301 knddnscrnp ehtdvideli dtklrleksk necqrlqniv mdctkeeeat mttsavsptv 361 gklfsdikvl krqlikernq kfqlqnqled filelehktp elisfkertk slehelkrst 421 elletvsltk rkqereitsl rqkingcean ihslvkqrld larqvkllll ntsaiqetas 481 plsqdelisl rkilessniv nendsqaiit erlvefsnvn elqeknvell nciriladkl 541 enyegkqdkt lqkvenqtik eakdaiiele ninakmetri nillrerdsy kllasteenk 601 antnsvtsme aarekkirel eaelsstkve nsaiiqnlrk elliykksqc kkkttledfe 661 nfkglakeke rmleeaidhl kaelekqksw vpsyihveke rastelsqsr ikiksleyei 721 sklkketasf iptkesltrd feqcckekke lqmrlkesei shnenkmdfs skegqykaki 781 kelennlerl rsdlqskiqe iesirsckds qlkwaqntid dtemkmksll telsnketti 841 eklsseienl dkelrktkfq ykfldqnsda stleptlrke leqiqvqlkd ansqiqayee 901 iissnenali elknelaktk enydakiele kkekwareed lsrlrgelge iralqpklke 961 galhfvqqse klrneveriq kmiekiekms tivqlckkke msqyqstmke nkdlselvir 1021 lekdaadcqa eltktkssly saqdlldkhe rkwmeekady erelisnieq teslrvensv 1081 liekvddtaa nngdkdhlkl vslfsnlrhe rnsletkltt ckrelafvkq kndslektin 1141 dlqrtqtlse keyqcsavii defkditkev tqvnilkenn ailqkslknv teknreiykq 1201 lndrqeeisr lqrdliqtke qvsinsnkil vyesemeqck qryqdlsqqq kdaqkkdiek 1261 ltneisdlkg klssaenana dlenkfnrlk kqahekldas kkqqaaltne lnelkaikdk 1321 leqdlhfena kvidldtklk ahelqsedvs rdhekdtyrt lmeeieslkk elqifktans 1381 ssdafeklkv nmekekdrii dertkefekk lqetlnksts seaeyskdie tlkkewlkey 1441 edetlrrike aeenlkkrir lpseeriqki iskrkeelee efrkklkena gsltfldnkg 1501 sgedaeeelw nspskgnser psavagfinq knlkpqeqlk nvkndvsfnd sqsmvtnken 1561 nivdssaagn kaiptfsfgk pffssntssl qsfqnpftas qsnintnapl rtlniqpeva 1621 vkaainfsnv tdltnnstdg akiteigsts krpiesgtss dpdtkkvkes pandqasne // LOCUS NP_012118 128 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-60S ribosomal protein eL40 RPL40A fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012118 VERSION NP_012118.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179496.1 REFERENCE 1 (residues 1 to 128) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 128) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 128) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 128) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08405. Method: conceptual translation. FEATURES Location/Qualifiers source 1..128 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..128 /product="ubiquitin-60S ribosomal protein eL40 RPL40A fusion protein" /calculated_mol_wt="14423" Region 1..76 /region_name="Ubl_ubiquitin" /note="ubiquitin-like (Ubl) domain found in ubiquitin; cd01803" /db_xref="CDD:340501" Site order(6..9,11,34..37,40,42,44,46..49,68..76) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:340501" Site order(8..12,31..35,40,42,44,46..49,68,70..76) /site_type="other" /note="E1 interaction site [polypeptide binding]" /db_xref="CDD:340501" Region 79..126 /region_name="Ribosomal_L40e" /note="Ribosomal L40e family; pfam01020" /db_xref="CDD:395807" CDS 1..128 /gene="RPL40A" /locus_tag="YIL148W" /gene_synonym="CEP52A; UB11; UBI1" /coded_by="NM_001179496.1:1..387" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:22096102]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:2538753]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:22995916]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:22995916]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:8035826]" /note="Ubiquitin-ribosomal 60S subunit protein L40A fusion protein; cleaved to yield ubiquitin and ribosomal protein L40A; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40A has a paralog, RPL40B, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:854658" /db_xref="SGD:S000001410" ORIGIN 1 mqifvktltg ktitlevess dtidnvkski qdkegippdq qrlifagkql edgrtlsdyn 61 iqkestlhlv lrlrggiiep slkalaskyn cdksvcrkcy arlppratnc rkrkcghtnq 121 lrpkkklk // LOCUS NP_012119 1220 aa linear PLN 30-JUN-2025 DEFINITION histidine kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012119 VERSION NP_012119.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179495.1 REFERENCE 1 (residues 1 to 1220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1220) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08406. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1220 /product="histidine kinase" /EC_number="2.7.13.3" /calculated_mol_wt="134305" Region <518..>553 /region_name="PRK10935" /note="nitrate/nitrite two-component system sensor histidine kinase NarQ" /db_xref="CDD:236800" Region <567..1210 /region_name="PRK11107" /note="hybrid sensory histidine kinase BarA; Provisional" /db_xref="CDD:236848" CDS 1..1220 /gene="SLN1" /locus_tag="YIL147C" /gene_synonym="YPD2" /coded_by="NM_001179495.1:1..3663" /experiment="EXISTENCE:direct assay:GO:0004673 protein histidine kinase activity [PMID:8808622]" /experiment="EXISTENCE:direct assay:GO:0005034 osmosensor activity [PMID:12821642]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10198019|PMID:14665464]" /experiment="EXISTENCE:direct assay:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:8808622]" /experiment="EXISTENCE:direct assay:GO:0009927 histidine phosphotransfer kinase activity [PMID:12455952]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0009927 histidine phosphotransfer kinase activity [PMID:12455952]" /note="Transmembrane histidine phosphotransfer kinase and osmosensor; regulates MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators" /db_xref="GeneID:854659" /db_xref="SGD:S000001409" ORIGIN 1 mrfglpskle ltppfrigir tqltalvsiv algsliilav ttgvyftsny knlrsdrlyi 61 aaqlkssqid qtlnylyyqa yylasrdalq ssltsyvagn ksadnwvdsl sviqkflsss 121 nlfyvakvyd ssfnavlnat nngtgdlipe dvldslfpls tdtplpssle tigiltdpvl 181 nstdylmsms lpifanpsii ltdsrvygyi tiimsaeglk svfndttale hstiaiisav 241 ynsqgkasgy hfvfppygsr sdlpqkvfsi kndtfissaf rngkggslkq tnilstrnta 301 lgyspcsfnl vnwvaivsqp esvflspatk lakiitgtvi aigvfvillt lplahwavqp 361 ivrlqkatel itegrglrps tprtisrass fkrgfssgfa vpssllqfnt aeagsttsvs 421 ghggsghgsg aafsanssmk sainlgnekm sppeeenkip nnhtdakism dgslnhdllg 481 phslrhndtd rssnrshilt tsanltearl pdyrrlfsde lsdltetfnt mtdaldqhya 541 lleervrart kqleaakiea eaaneaktvf ianishelrt plngilgmta ismeetdvnk 601 irnslklifr sgelllhilt elltfsknvl qrtklekrdf citdvalqik sifgkvakdq 661 rvrlsislfp nlirtmvlwg dsnriiqivm nlvsnalkft pvdgtvdvrm kllgeydkel 721 sekkqykevy ikkgtevten lettdkydlp tlsnhrksvd lessatslgs nrdtstiqee 781 itkrntvane siykkvndre kasnddvssi vstttssydn aifnsqfnka pgsddeeggn 841 lgrpienpkt wvisievedt gpgidpslqe svfhpfvqgd qtlsrqyggt glglsicrql 901 anmmhgtmkl eskvgvgskf tftlplnqtk eisfadmefp fedefnpesr knrrvkfsva 961 ksiksrqsts svatpatnrs sltndvlpev rskgkhetkd vgnpnmgree kndnggleql 1021 qeknikpsic ltgaevneqn slsskhrsrh eglgsvnldr pflqstgtat ssrniptvkd 1081 ddknetsvki lvvednhvnq evikrmlnle gienielacd gqeafdkvke ltskgenynm 1141 ifmdvqmpkv dgllstkmir rdlgytspiv altafaddsn ikeclesgmn gflskpikrp 1201 klktiltefc aayqgkknnk // LOCUS NP_012120 529 aa linear PLN 30-JUN-2025 DEFINITION mitophagy protein ATG32 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012120 VERSION NP_012120.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179494.1 REFERENCE 1 (residues 1 to 529) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 529) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 529) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 529) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08407. Method: conceptual translation. FEATURES Location/Qualifiers source 1..529 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..529 /product="mitophagy protein ATG32" /calculated_mol_wt="58838" Region 204..341 /region_name="psREC_Atg32" /note="pseudo receiver domain of autophagy receptor Atg32; cd19929" /db_xref="CDD:381156" CDS 1..529 /gene="ATG32" /locus_tag="YIL146C" /gene_synonym="ECM37" /coded_by="NM_001179494.1:1..1590" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:29673596]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:19619495|PMID:19619494]" /experiment="EXISTENCE:genetic interaction:GO:0031930 mitochondria-nucleus signaling pathway [PMID:30298458]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19619494|PMID:19619495]" /experiment="EXISTENCE:mutant phenotype:GO:0140580 mitochondrion autophagosome adaptor activity [PMID:27992522]" /note="Mitochondrial outer membrane protein required to initiate mitophagy; recruits the autophagy adaptor protein Atg11p and the ubiquitin-like protein Atg8p to the mitochondrial surface to initiate mitophagy, the selective vacuolar degradation of mitochondria in response to starvation; can promote pexophagy when placed ectopically in the peroxisomal membrane; regulates mitophagy and ethanol production during alcoholic fermentation" /db_xref="GeneID:854660" /db_xref="SGD:S000001408" ORIGIN 1 mvleyqqreg kgsssksmpp dsssttihtc seaqtgedkg lldphlsvle llsktghsps 61 pmgqnlvtsi disgnhnvnd sisgswqaiq pldlgasfip ercssqttng silsssdtse 121 eeqellqapa adiiniikqg qeganvvsps hpfkqlqkii slplpgkekt pfneqdddgd 181 edeafeedsv titksltsst nsfvmpklsl tqknpvfrll ilgrtgssfy qsipkeyqsl 241 felpkyhdsa tfpqytgivi ifqelremvs llnrivqysq gkpvipicqp gqviqvknvl 301 ksflrnklvk llfppvvvtn krdlkkmfqr lqdlsleyge dvneedndde aihtksrsyc 361 rnkkaenskk kspksnkkpk rkkqkfftsw ftwgisitig isfgccvtyf vtaayehqtv 421 kslslrpsil asllsldsss dtintpatas pssteqflwf dkgtlqinfh sdgfimkslt 481 iiketwgkmn tfvlhalskp lkflenlnks sefsidesnr ilalgyill // LOCUS NP_012121 309 aa linear PLN 30-JUN-2025 DEFINITION pantoate--beta-alanine ligase PAN6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012121 VERSION NP_012121.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179493.1 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08408. On Oct 2, 2003 this sequence version replaced NP_012121.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..309 /product="pantoate--beta-alanine ligase PAN6" /EC_number="6.3.2.1" /calculated_mol_wt="34901" Region 1..309 /region_name="nt_trans" /note="nucleotidyl transferase superfamily; cl00015" /db_xref="CDD:469580" Site order(31..34,37,39..40,43,61,64,74,139,142..143,157..158, 160..161,164,185..187,195..198) /site_type="active" /db_xref="CDD:185673" Site order(31..33,37,40,43,64,142..143,157..158,160..161,164, 186..187,194..195) /site_type="other" /note="ATP-binding site [chemical binding]" /db_xref="CDD:185673" Site order(31,33,61,64,142..143,146,164) /site_type="active" /note="pantoate-binding site [active]" /db_xref="CDD:185673" Site 37..40 /site_type="other" /note="HXXH motif" /db_xref="CDD:185673" CDS 1..309 /gene="PAN6" /locus_tag="YIL145C" /coded_by="NM_001179493.1:1..930" /experiment="EXISTENCE:direct assay:GO:0004592 pantoate-beta-alanine ligase activity [PMID:10417331]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]" /note="Pantothenate synthase; also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC" /db_xref="GeneID:854661" /db_xref="SGD:S000001407" ORIGIN 1 mkifhtveev vqwrtqelre trfretigfv ptmgclhsgh aslisqsvke ntytvvsifv 61 npsqfapted ldnyprtlpd diklleslkv dvlfapnahv mypqgipldi eeqkgpfvsv 121 lglseklegk trpnffrgva tvvtklfniv madvayfgqk diqqfivlqc mvdelfvntr 181 lqmmpivrnn nglalssrnk ylcpeslkis enlyrglkaa enairrlapg grlsrseiid 241 tvtqiwapyv dshdfkidyv sladfktlde lsdventseq qpiviscavy vtdrekpdtv 301 vrlidnivi // LOCUS NP_012122 691 aa linear PLN 30-JUN-2025 DEFINITION kinetochore-associated Ndc80 complex subunit NDC80 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012122 VERSION NP_012122.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179492.3 REFERENCE 1 (residues 1 to 691) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 691) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 691) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 691) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08409. On Jul 30, 2012 this sequence version replaced NP_012122.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..691 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..691 /product="kinetochore-associated Ndc80 complex subunit NDC80" /calculated_mol_wt="80357" Region 91..247 /region_name="Ndc80_HEC" /note="HEC/Ndc80p family; pfam03801" /db_xref="CDD:461058" Region <241..621 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" CDS 1..691 /gene="NDC80" /locus_tag="YIL144W" /gene_synonym="HEC1; TID3" /coded_by="NM_001179492.3:1..2076" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:27170178|PMID:11511347]" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:11266451]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:17195848]" /experiment="EXISTENCE:direct assay:GO:0031262 Ndc80 complex [PMID:11266451|PMID:11179222]" /experiment="EXISTENCE:mutant phenotype:GO:0000776 kinetochore [PMID:11179222]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11266451]" /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:19893618|PMID:19952112]" /experiment="EXISTENCE:physical interaction:GO:0031262 Ndc80 complex [PMID:11179222]" /note="Component of the kinetochore-associated Ndc80 complex; conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, and kinetochore assembly and clustering; evolutionarily conserved; complex members include Ndc80p, Nuf2p, Scp24p, and Spc25p; modified by sumoylation" /db_xref="GeneID:854662" /db_xref="SGD:S000001406" ORIGIN 1 mqsststdqh vlhhmdphrf tsqiptatss qlrrrnstnq gltdminksi arntisgtgi 61 ptgginknkr trstvaggtn gtalalndks nsrnsvsrls inqlgslqqh lsnrdprplr 121 dknfqsaiqe eiydylkknk fdietnhpis ikflkqptqk gfiiifkwly lrldpgygft 181 ksieneiyqi lknlrypfle sinksqisav ggsnwhkflg mlhwmvrtni kldmclnkvd 241 rslinqntqe itilsqplkt ldeqdqrqer yelmveklli dyftesyksf lklednyeps 301 mqelklgfek fvhiintdia nlqtqndnly ekyqevmkis qkikttrekw kalksdsnky 361 enyvnamkqk sqewpgklek mksecelkee eikalqsnis elhkilrkkg isteqfelqn 421 qerekltrel dkiniqsdkl tssiksrkle aegifkslld tlrqydssiq nltrsrsqlg 481 hnvndsslki nisenlldrd fhegisyeql fpkgsgines ikksilklnd eiqeriktie 541 kdnitlekdi knlkhdinek tqineklele lseanskfel skqenerllv aqrieiekme 601 kkindsnllm ktkisdaeel vtstelklee lkvdlnrkry klhqqvihvi ditskfkini 661 qsslensene lgnvieelrn lefetehnvt n // LOCUS NP_012123 843 aa linear PLN 30-JUN-2025 DEFINITION TFIIH/NER complex ATPase/helicase subunit SSL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012123 VERSION NP_012123.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179491.1 REFERENCE 1 (residues 1 to 843) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 843) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 843) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 843) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08410. Method: conceptual translation. FEATURES Location/Qualifiers source 1..843 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..843 /product="TFIIH/NER complex ATPase/helicase subunit SSL2" /EC_number="5.6.2.4" /calculated_mol_wt="95210" Region 117..835 /region_name="rad25" /note="DNA repair helicase rad25; TIGR00603" /db_xref="CDD:273168" CDS 1..843 /gene="SSL2" /locus_tag="YIL143C" /gene_synonym="LOM3; RAD25" /coded_by="NM_001179491.1:1..2532" /experiment="EXISTENCE:direct assay:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:8855246]" /experiment="EXISTENCE:direct assay:GO:0000439 transcription factor TFIIH core complex [PMID:7961739]" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:8202161]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:8631896]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0097550 transcription preinitiation complex [PMID:22751016]" /experiment="EXISTENCE:mutant phenotype:GO:0000019 regulation of mitotic recombination [PMID:10713167]" /experiment="EXISTENCE:mutant phenotype:GO:0001111 RNA polymerase II promoter clearance [PMID:10713451]" /experiment="EXISTENCE:mutant phenotype:GO:0001113 transcription open complex formation at RNA polymerase II promoter [PMID:10409754]" /experiment="EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:34652274]" /experiment="EXISTENCE:mutant phenotype:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:25775526]" /experiment="EXISTENCE:mutant phenotype:GO:0015616 DNA translocase activity [PMID:25775526]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:17212653]" /note="Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3" /db_xref="GeneID:854663" /db_xref="SGD:S000001405" ORIGIN 1 mtdvegyqpk skgkifpdmg esffssdeds patdaeiden yddnretseg rgerdtgamv 61 tglkkprkkt kssrhtaads smnqmdakdk allqdtnsdi padfvpdsvs gmfrshdfsy 121 lrlrpdhasr plwispsdgr iilesfspla eqaqdflvti aepisrpshi heykitaysl 181 yaavsvglet ddiisvldrl skvpvaesii nfikgatisy gkvklvikhn ryfvettqad 241 ilqmllndsv igplridsdh qvqppedvlq qqlqqtagkp atnvnpndve avfsaviggd 301 nereeedddi davhsfeian esvevvkkrc qeidypvlee ydfrndhrnp dldidlkpst 361 qirpyqeksl skmfgngrar sgiivlpcga gktlvgitaa ctikksvivl ctssvsvmqw 421 rqqflqwctl qpencavfts dnkemfqtes glvvstysmv antrnrshds qkvmdfltgr 481 ewgfiildev hvvpaamfrr vvstiaahak lgltatlvre ddkigdlnfl igpklyeanw 541 melsqkghia nvqcaevwcp mtaefyqeyl retarkrmll yimnptkfqa cqfliqyher 601 rgdkiivfsd nvyalqeyal kmgkpfiygs tpqqermnil qnfqyndqin tiflskvgdt 661 sidlpeatcl iqisshygsr rqeaqrlgri lrakrrndeg fnaffyslvs kdtqemyyst 721 krqaflvdqg yafkvithlh gmenipnlay asprerrell qevllkneea agievgddad 781 nsvgrgsngh krfkskavrg egslsglagg edmaymeyst nknkelkehh plirkmyykn 841 lkk // LOCUS NP_012124 527 aa linear PLN 30-JUN-2025 DEFINITION chaperonin-containing T-complex subunit CCT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012124 VERSION NP_012124.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179490.1 REFERENCE 1 (residues 1 to 527) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 527) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 527) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 527) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08411. Method: conceptual translation. FEATURES Location/Qualifiers source 1..527 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..527 /product="chaperonin-containing T-complex subunit CCT2" /calculated_mol_wt="57072" Region 5..520 /region_name="TCP1_beta" /note="TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL)...; cd03336" /db_xref="CDD:239452" Site order(10,14,42..45,47,66,68,72,76,79,374,510..516) /site_type="other" /note="ring oligomerisation interface [polypeptide binding]" /db_xref="CDD:239452" Site order(37..39,90,94,159,386,404,444,487,489) /site_type="other" /note="ATP/Mg binding site [chemical binding]" /db_xref="CDD:239452" Site order(424,442,451,453..454,457) /site_type="active" /note="stacking interactions [active]" /db_xref="CDD:239452" CDS 1..527 /gene="CCT2" /locus_tag="YIL142W" /gene_synonym="BIN3; TCP2" /coded_by="NM_001179490.1:1..1584" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Subunit beta of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo" /db_xref="GeneID:854664" /db_xref="SGD:S000001404" ORIGIN 1 msvqifgdqv teeraenarl safvgaiavg dlvkstlgpk gmdkllqsas sntcmvtndg 61 atilksipld npaakvlvni skvqddevgd gttsvtvlsa ellreaekli dqskihpqti 121 iegyrlasaa aldaltkaav dnshdktmfr edlihiaktt lsskilsqdk dhfaelatna 181 ilrlkgstnl ehiqiikilg gklsdsflde gfilakkfgn nqpkrienak ilianttldt 241 dkvkifgtkf kvdstaklaq lekaerekmk nkiakiskfg intfinrqli ydypeqlftd 301 lginsiehad fegverlalv tggevvstfd epskcklgec dvieeimlge qpflkfsgck 361 ageactivlr gatdqtldea erslhdalsv lsqttketrt vlgggcaemv mskavdteaq 421 nidgkkslav eafaralrql ptiladnagf dsselvsklr ssiyngists gldlnngtia 481 dmrqlgives yklkravvss aseaaevllr vdniirarpr tanrqhm // LOCUS NP_012126 823 aa linear PLN 30-JUN-2025 DEFINITION Axl2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012126 VERSION NP_012126.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179488.1 REFERENCE 1 (residues 1 to 823) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 823) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 823) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 823) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 823) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 823) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 823) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08412. Method: conceptual translation. FEATURES Location/Qualifiers source 1..823 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..823 /product="Axl2p" /calculated_mol_wt="90653" Region 28..115 /region_name="Dystroglycan_repeat" /note="Cadherin-like repeat domain of alpha dystroglycan; cd11303" /db_xref="CDD:206636" Region 148..250 /region_name="CADG" /note="Dystroglycan-type cadherin-like domains; smart00736" /db_xref="CDD:214795" Region 352..447 /region_name="CADG" /note="Dystroglycan-type cadherin-like domains; smart00736" /db_xref="CDD:214795" CDS 1..823 /gene="AXL2" /locus_tag="YIL140W" /gene_synonym="BUD10; SRO4" /coded_by="NM_001179488.1:1..2472" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:8846915]" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:8846915]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8846915]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:8846915]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:8846915]" /note="Integral plasma membrane protein; required for axial budding in haploid cells; localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate" /db_xref="GeneID:854666" /db_xref="SGD:S000001402" ORIGIN 1 mtqlqislll tatisllhlv vatpyeaypi gkqyppvarv nesftfqisn dtykssvdkt 61 aqityncfdl pswlsfdsss rtfsgepssd llsdanttly fnvilegtds adstslnnty 121 qfvvtnrpsi slssdfnlla llknygytng knalkldpne vfnvtfdrsm ftneesivsy 181 ygrsqlynap lpnwlffdsg elkftgtapv insaiapets ysfviiatdi egfsavevef 241 elvigahqlt tsiqnsliin vtdtgnvsyd lplnyvyldd dpissdklgs inlldapdwv 301 aldnatisgs vpdellgkns npanfsvsiy dtygdviyfn fevvsttdlf aisslpnina 361 trgewfsyyf lpsqftdyvn tnvsleftns sqdhdwvkfq ssnltlagev pknfdklslg 421 lkanqgsqsq elyfniigmd skithsnhsa natstrsshh ststssytss tytakissts 481 aaatssapaa lpaanktssh nkkavaiacg vaiplgvilv alicflifwr rrrenpdden 541 lphaisgpdl nnpankpnqe natplnnpfd ddassyddts iarrlaalnt lkldnhsate 601 sdissvdekr dslsgmntyn dqfqsqskee llakppvqpp espffdpqnr sssvymdsep 661 avnkswrytg nlspvsdivr dsygsqktvd teklfdleap ekekrtsrdv tmssldpwns 721 nispspvrks vtpspynvtk hrnrhlqniq dsqsgkngit pttmstsssd dfvpvkdgen 781 fcwvhsmepd rrpskkrlvd fsnksnvnvg qvkdihgrip eml // LOCUS NP_012127 245 aa linear PLN 30-JUN-2025 DEFINITION Rev7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012127 VERSION NP_012127.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179487.1 REFERENCE 1 (residues 1 to 245) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 245) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 245) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 245) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08413. Method: conceptual translation. FEATURES Location/Qualifiers source 1..245 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..245 /product="Rev7p" /calculated_mol_wt="28629" Region 7..>141 /region_name="HORMA" /note="HORMA domain; pfam02301" /db_xref="CDD:460526" CDS 1..245 /gene="REV7" /locus_tag="YIL139C" /coded_by="NM_001179487.1:1..738" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16546083]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:8658138]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16452144]" /experiment="EXISTENCE:direct assay:GO:0016035 zeta DNA polymerase complex [PMID:22711820|PMID:23066099|PMID:8658138]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:11313481]" /experiment="EXISTENCE:direct assay:GO:0070987 error-free translesion synthesis [PMID:12514101]" /experiment="EXISTENCE:genetic interaction:GO:0042276 error-prone translesion synthesis [PMID:9765213]" /experiment="EXISTENCE:mutant phenotype:GO:0042276 error-prone translesion synthesis [PMID:3897795]" /note="Accessory subunit of DNA polymerase zeta (pol zeta); involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; may be involved in meiosis; forms a complex with Rev3p, Pol31p and Pol32p" /db_xref="GeneID:854667" /db_xref="SGD:S000001401" ORIGIN 1 mnrwvekwlr vylkcyinli lfyrnvyppq sfdyttyqsf nlpqfvpinr hpalidyiee 61 lildvlsklt hvyrfsicii nkkndlciek yvldfselqh vdkddqiite tevfdefrss 121 lnslimhlek lpkvnddtit feavinaiel elghkldrnr rvdsleekae ierdsnwvkc 181 qedenlpdnn gfqppkiklt slvgsdvgpl iihqfsekli sgddkilngv ysqyeegesi 241 fgslf // LOCUS NP_012128 161 aa linear PLN 30-JUN-2025 DEFINITION tropomyosin TPM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012128 VERSION NP_012128.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179486.3 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08414. On Jul 30, 2012 this sequence version replaced NP_012128.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..161 /product="tropomyosin TPM2" /calculated_mol_wt="18962" Region 7..148 /region_name="Tropomyosin_1" /note="Tropomyosin like; pfam12718" /db_xref="CDD:403808" CDS 1..161 /gene="TPM2" /locus_tag="YIL138C" /coded_by="NM_001179486.3:1..486" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:9864365]" /experiment="EXISTENCE:direct assay:GO:0003786 actin lateral binding [PMID:11457840]" /experiment="EXISTENCE:direct assay:GO:0005884 actin filament [PMID:7844152]" /experiment="EXISTENCE:direct assay:GO:0032432 actin filament bundle [PMID:9864365]" /experiment="EXISTENCE:direct assay:GO:1904530 negative regulation of actin filament binding [PMID:7844152]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:9864365]" /experiment="EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:12419188]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:7844152]" /note="Minor isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p; TPM2 has a paralog, TPM1, that arose from the whole genome duplication" /db_xref="GeneID:854668" /db_xref="SGD:S000001400" ORIGIN 1 mekikeklns lkleseswqe kyeelreqlk eleqsnteke neikslsakn eqldsevekl 61 esqlsdtkql aedsnnlrsn nenytkknqd leqqledsea klkeamdklk eadlnseqmg 121 rrivaleeer dewekkceef qskyeeaqke ldeianslen l // LOCUS NP_012129 946 aa linear PLN 30-JUN-2025 DEFINITION Tma108p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012129 VERSION NP_012129.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179485.1 REFERENCE 1 (residues 1 to 946) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 946) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 946) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 946) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08415. Method: conceptual translation. FEATURES Location/Qualifiers source 1..946 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..946 /product="Tma108p" /calculated_mol_wt="107592" Region 15..488 /region_name="M1_APN-Q_like" /note="Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1); cd09601" /db_xref="CDD:341064" Site order(153,155,293..296,330..331,334,353,357,418,423) /site_type="active" /db_xref="CDD:341064" Region 564..924 /region_name="ERAP1_C" /note="ERAP1-like C-terminal domain; pfam11838" /db_xref="CDD:463368" CDS 1..946 /gene="TMA108" /locus_tag="YIL137C" /gene_synonym="TAE3" /coded_by="NM_001179485.1:1..2841" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005854 nascent polypeptide-associated complex [PMID:27580715]" /experiment="EXISTENCE:direct assay:GO:1990593 nascent polypeptide-associated complex binding [PMID:27580715]" /experiment="EXISTENCE:genetic interaction:GO:0042254 ribosome biogenesis [PMID:20691087]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:20691087]" /experiment="EXISTENCE:mutant phenotype:GO:2000765 regulation of cytoplasmic translation [PMID:27580715]" /note="Ribosome-associated, nascent chain binding factor; binds N-terminal region of nascent peptides during translation; recognizes target proteins via its putative metallopeptidase peptide-binding pocket" /db_xref="GeneID:854669" /db_xref="SGD:S000001399" ORIGIN 1 msdnllslen pvvpshyelr leidpkqssp nfkgsaiihl kfnpnsttla siedsftqfk 61 lhskdlivls ahatigstkf dlkisqdtgk hlsifnsesp iqlsndcpli lsvqyvgkir 121 dikthhdktf gifktnfmdr ktgtannhvv athcqpfsas nifpcideps nkstfqlnia 181 tdaqykavsn tpvemveald ssqkhlvkfa ktplmttsvf gfsigdlefl kteiklegdr 241 tipvsiyapw dianaaftld tvqkylplle syfkcpyplp kldfvllpyl sdmamenfgm 301 itiqlnhlli ppnalanetv reqaqqlivh elvhqwmgny isfdsweslw fnesfatwla 361 chileqngdl shywtsepyl lqqveptmcr daadvngrsi fqiaqrntgi dsqtsdifdp 421 eaytkgiiml rslqlatges hlqkglesvf edtktfhars vkpmdiwnhi gkflksqnit 481 nfvsswtrtp glpvvkveve ekdgktqtkl tqhrfinqls teekdqledv pyqvplfgvl 541 pdgkmdtknv lltdrtlkfd ypilvinhla qgyyrvsyes eecyalindk iteetlseid 601 lrkifldlsq figdegfqns ihlhglfkil nhiaspstki askywdplsk glevlqtidr 661 asltssklqs flkkkivipl fnkidwphge fdkstnphel kvmsqvlfln knsakcaelc 721 qiyfkhllqg prssvplelv nsilvvvsqh canikqwkki fdlvkrssct gitnhvinmy 781 dqnssetaml iqngaieslg fcldsdivkk tlnfitsnie segmelalfg fnynfkkrln 841 knekpqdqvv retiwewymg nfdqwarkat rkgtttgdhl hkalrsisli ifqmfvadep 901 qkiekfinle keklgqslls lddiwasvqq deesrktirr dlaslv // LOCUS NP_012130 393 aa linear PLN 30-JUN-2025 DEFINITION Om45p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012130 VERSION NP_012130.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179484.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08416. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..393 /product="Om45p" /calculated_mol_wt="44449" Region <126..>384 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" CDS 1..393 /gene="OM45" /locus_tag="YIL136W" /coded_by="NM_001179484.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:11502169|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:16689936|PMID:11179417]" /note="Mitochondrial outer membrane hypothetical protein; major constituent of the outer membrane, extending into the intermembrane space; interacts with porin (Por1p) and with Om14p; imported via the presequence pathway involving the TOM and TIM23 complexes, then assembled in the outer membrane by Mim1p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854670" /db_xref="SGD:S000001398" ORIGIN 1 mssriivgsa alaaaitasi mvreqkakgq rregnvsayy ngqeygssap pqlgklhnik 61 qgikedalsl kdallgvsqk areeapkvtk rvispeedaq trkqlgqkak dsssqsifnw 121 gfseaerrka iaigefdtak krfeeavdrn ekellstvmr ekkaaldras ieyerygrar 181 dfnelsdkld qqernsnplk rllknntgda nteeaaarsv qgwgdtaqef greeleeakr 241 nassepseaq krldelkkik ekgwfgynkg eqseqqiaer varglegwge taaqlskdem 301 ddlrwnyens kkqldknvsd amdslskake dlkqygshww sgwtskvdnd kqalkdeaqk 361 kydealkkyd eaknkfkewn dkgdgkfwss kkd // LOCUS NP_012131 436 aa linear PLN 30-JUN-2025 DEFINITION Vhs2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012131 VERSION NP_012131.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179483.1 REFERENCE 1 (residues 1 to 436) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 436) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 436) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 436) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08417. Method: conceptual translation. FEATURES Location/Qualifiers source 1..436 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..436 /product="Vhs2p" /calculated_mol_wt="47830" CDS 1..436 /gene="VHS2" /locus_tag="YIL135C" /coded_by="NM_001179483.1:1..1311" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:16816427]" /experiment="EXISTENCE:genetic interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:16816427]" /experiment="EXISTENCE:genetic interaction:GO:0032186 cellular bud neck septin ring organization [PMID:24646733]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:16816427]" /experiment="EXISTENCE:mutant phenotype:GO:0032186 cellular bud neck septin ring organization [PMID:24646733]" /note="Regulator of septin dynamics; involved in the regulation of septin dynamics at bud neck after mitotic entry, likely by stabilizing septin structure; regulated at post-translational level by cell cycle dependent phosphorylation; likely phosphorylated by Cdc28p and dephosphorylated by Cdc14p before cytokinesis; high-copy suppressor of synthetic lethality of sis2 sit4 double mutant; VHS2 has a paralog, MLF3, that arose from the whole genome duplication" /db_xref="GeneID:854671" /db_xref="SGD:S000001397" ORIGIN 1 mdtsnhnqdh dshvaaqren dnnymppsps msessmifer nvedpsylyk tvsnnaansl 61 srqssrtslf nhnnssnrnf hnlsqrssav nlhlqpsrtn esiasyqtyn pdfvvqtpld 121 hrrtlenfvp paldagcsiv tddttglddv dmvysrrpst igldralgrt rslssqsfdn 181 etspahprsp ndhgsrllrf ysyadmlsdd nnnnvsnats tsstanplrr ppmqghysfs 241 ssllnspshl psppsasasp pqhmnftnpf iisrrysntt innanggtsa gsttgaalsr 301 spsnqqyllk qqrspsgsar srrnsnrpgs aanimigkpk skfhmessgs egfsseeedn 361 tmierdklnl kqklqsqlaq ppsianmvnd nhnntnkhkn tinnniknsp aftnsnpssk 421 snsnstitsm npdttk // LOCUS NP_878096 67 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL134C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878096 VERSION NP_878096.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184555.1 REFERENCE 1 (residues 1 to 67) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 67) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 67) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 67) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08418. Method: conceptual translation. FEATURES Location/Qualifiers source 1..67 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..67 /product="uncharacterized protein" /calculated_mol_wt="7467" CDS 1..67 /locus_tag="YIL134C-A" /coded_by="NM_001184555.1:1..204" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466491" /db_xref="SGD:S000028556" ORIGIN 1 mvvgsefnnt advdvvaill tllnadyfvi kqrlvsacft krikwyfiya iallslfssr 61 ntvcapy // LOCUS NP_012132 311 aa linear PLN 30-JUN-2025 DEFINITION flavin adenine dinucleotide transporter FLX1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012132 VERSION NP_012132.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179482.3 REFERENCE 1 (residues 1 to 311) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 311) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 311) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 311) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08419. On Jul 30, 2012 this sequence version replaced NP_012132.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..311 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..311 /product="flavin adenine dinucleotide transporter FLX1" /calculated_mol_wt="34278" Region 5..105 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 122..215 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 223..311 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..311 /gene="FLX1" /locus_tag="YIL134W" /coded_by="NM_001179482.3:1..936" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762|PMID:14576278|PMID:16823961|PMID:8631763]" /experiment="EXISTENCE:mutant phenotype:GO:0015230 FAD transmembrane transporter activity [PMID:8631763|PMID:14555654]" /experiment="EXISTENCE:mutant phenotype:GO:0015883 FAD transport [PMID:14555654]" /note="Mitochondrial flavin adenine dinucleotide transporter; FAD is a synthesis product of riboflavin; human homolog SLC25A32 is implicated in multiple acyl-CoA dehydrogenase deficiency (MADD) or glutaric aciduria type II (GAII), and can complement yeast null mutant" /db_xref="GeneID:854672" /db_xref="SGD:S000001396" ORIGIN 1 mvdhqwtplq kevisglsag svttlvvhpl dllkvrlqls atsaqkahyg pfmvikeiir 61 ssansgrsvt nelyrglsin lfgnaiawgv yfglygvtke liyksvakpg etqlkgvgnd 121 hkmnsliyls agassglmta iltnpiwvik trimstskga qgaytsmyng vqqllrtdgf 181 qglwkglvpa lfgvsqgaly favydtlkqr klrrkrengl dihltnleti eitslgkmvs 241 vtlvypfqll ksnlqsfran eqkfrlfpli kliiandgfv glykglsanl vraipstcit 301 fcvyenlkhr l // LOCUS NP_012133 199 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL13 RPL16A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012133 VERSION NP_012133.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179481.1 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08420. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..199 /product="60S ribosomal protein uL13 RPL16A" /calculated_mol_wt="22070" Region 6..199 /region_name="PTZ00068" /note="60S ribosomal protein L13a; Provisional" /db_xref="CDD:240253" Site order(15,17..18,21,24,28,44,46,74..75,81..83,85..87,89, 91..92,94,96,100,103..104) /site_type="other" /note="23S rRNA interface [nucleotide binding]" /db_xref="CDD:238230" Site 75 /site_type="other" /note="L3 interface [polypeptide binding]" /db_xref="CDD:238230" CDS 1..199 /gene="RPL16A" /locus_tag="YIL133C" /gene_synonym="RPL13" /coded_by="NM_001179481.1:1..600" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:27374275]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:27374275]" /note="Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854673" /db_xref="SGD:S000001395" ORIGIN 1 msvepvvvid gkghlvgrla svvakqllng qkivvvraee lnisgeffrn klkyhdflrk 61 atafnktrgp fhfrapsrif ykalrgmvsh ktargkaale rlkvfegipp pydkkkrvvv 121 pqalrvlrlk pgrkyttlgk lstsvgwkye dvvakleakr kvssaeyyak kraftkkvas 181 anataaesdv akqlaalgy // LOCUS NP_012134 213 aa linear PLN 30-JUN-2025 DEFINITION Csm2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012134 VERSION NP_012134.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179480.1 REFERENCE 1 (residues 1 to 213) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 213) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 213) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 213) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08421. Method: conceptual translation. FEATURES Location/Qualifiers source 1..213 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..213 /product="Csm2p" /calculated_mol_wt="24822" Region 7..212 /region_name="Csm2" /note="Shu complex subunit Csm2; cd19478" /db_xref="CDD:410886" Site order(8,88,123,136,139..140,144,147..148,151,196..199,202, 205..209) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:410886" CDS 1..213 /gene="CSM2" /locus_tag="YIL132C" /coded_by="NM_001179480.1:1..642" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0097196 Shu complex [PMID:23575680]" /experiment="EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:15654096]" /experiment="EXISTENCE:genetic interaction:GO:0043007 maintenance of rDNA [PMID:21372173]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:23575680]" /experiment="EXISTENCE:mutant phenotype:GO:0000730 DNA recombinase assembly [PMID:23575680]" /experiment="EXISTENCE:mutant phenotype:GO:0035861 site of double-strand break [PMID:23575680]" /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:11470404]" /experiment="EXISTENCE:physical interaction:GO:0097196 Shu complex [PMID:15654096]" /note="Subunit of the Shu complex (aka PCSS complex); Shu complex also includes Psy3, Shu1, Shu2, and promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p anti-recombinase function; promotes formation of Rad51p filaments; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis" /db_xref="GeneID:854674" /db_xref="SGD:S000001394" ORIGIN 1 meyedlelit iwpsptknkl cqfikqnlsk ehvvtqlffi datssfplsq fqklvpptlp 61 envriyenir intcldleel saitvkllqi lsmnkinaqr gtedavtepl kiilyingle 121 vmfrnsqfks spqrshellr dtllklrvmg ndenenasir tllefpkeql ldyylkknnn 181 trtssvrskr rrikngdsla eyiwkyyads lfe // LOCUS NP_012135 484 aa linear PLN 30-JUN-2025 DEFINITION forkhead family transcription factor FKH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012135 VERSION NP_012135.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179479.1 REFERENCE 1 (residues 1 to 484) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 484) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 484) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 484) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08422. Method: conceptual translation. FEATURES Location/Qualifiers source 1..484 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..484 /product="forkhead family transcription factor FKH1" /calculated_mol_wt="53359" Region 1..484 /region_name="COG5025" /note="Transcription factor of the Forkhead/HNF3 family [Transcription]" /db_xref="CDD:227358" CDS 1..484 /gene="FKH1" /locus_tag="YIL131C" /coded_by="NM_001179479.1:1..1455" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:10894548|PMID:11562353]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10894548]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11562353|PMID:10894548]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:24504085]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:22265405|PMID:24504085]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:20847055|PMID:10747051]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:10683251]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363|PMID:24504085]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:17898805|PMID:10894548]" /experiment="EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10959837|PMID:10747051|PMID:10894548|PMID:11562353]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10894548|PMID:17898805]" /experiment="EXISTENCE:genetic interaction:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10894548]" /experiment="EXISTENCE:genetic interaction:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11562353|PMID:10894548]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:17283050]" /experiment="EXISTENCE:genetic interaction:GO:0006369 termination of RNA polymerase II transcription [PMID:12702877]" /experiment="EXISTENCE:genetic interaction:GO:0007535 donor selection [PMID:12183363|PMID:16809780]" /experiment="EXISTENCE:genetic interaction:GO:0034244 negative regulation of transcription elongation by RNA polymerase II [PMID:12702877]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10959837|PMID:10894548|PMID:10747051|PMID:11562353]" /experiment="EXISTENCE:genetic interaction:GO:0090055 positive regulation of silent mating-type cassette heterochromatin formation [PMID:18045995|PMID:10747051]" /experiment="EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:10747051|PMID:10894548]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10747051|PMID:18045995]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10747051|PMID:18045995]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:17283050]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:12702877]" /experiment="EXISTENCE:mutant phenotype:GO:0007535 donor selection [PMID:27257873|PMID:12183363|PMID:16809780]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:12702877]" /experiment="EXISTENCE:mutant phenotype:GO:0032298 positive regulation of DNA-templated DNA replication initiation [PMID:22265405]" /experiment="EXISTENCE:mutant phenotype:GO:0034244 negative regulation of transcription elongation by RNA polymerase II [PMID:12702877]" /experiment="EXISTENCE:mutant phenotype:GO:0090055 positive regulation of silent mating-type cassette heterochromatin formation [PMID:10747051]" /experiment="EXISTENCE:mutant phenotype:GO:1903468 positive regulation of DNA replication initiation [PMID:26728715]" /note="Forkhead family transcription factor; rate-limiting replication origin activator; evolutionarily conserved lifespan regulator; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; regulates transcription elongation, chromatin silencing at mating loci, expression of G2/M phase genes; facilitates clustering, activation of early-firing replication origins; binds HML recombination enhancer, regulates donor preference during mating-type switching" /db_xref="GeneID:854675" /db_xref="SGD:S000001393" ORIGIN 1 msvtsreqkf sgkyssytaq drqglvnavt cvlssssdpv avssdysnsl siarevnaya 61 kiagcdwtyy vqklevtigr ntdslnlnav pgtvvkknid idlgpakivs rkhaairfnl 121 esgswelqif grngakvnfr riptgpdspp tvlqsgciid iggvqmifil peqetiisdy 181 clnhlmpkll stygtngnnn pllrniiegs tylreqrlqe earlqqldhl htplssssdv 241 npigdphgdt immeedeede nytrggirpn tytsssnnav tngnvphien psdlsldenr 301 yikppqsyas mitqailstp egsisladiy kfisdnyafy rfsqmawqns vrhnlslnka 361 fekvpkragq qgkgmnwkis devrrdflnk wnagklskir rgasvtrqlq lhmskfgeip 421 apesssidpr gikaqkvkks lqatssilge sapqlqrtql tgqistttsm dvttnanvnn 481 ssls // LOCUS NP_012136 964 aa linear PLN 30-JUN-2025 DEFINITION Asg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012136 VERSION NP_012136.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179478.1 REFERENCE 1 (residues 1 to 964) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 964) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 964) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 964) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08423. Method: conceptual translation. FEATURES Location/Qualifiers source 1..964 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..964 /product="Asg1p" /calculated_mol_wt="108650" Region 15..56 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(16,20,25..28,30,33,42) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(21,24,31,37,40,47) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 241..662 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..964 /gene="ASG1" /locus_tag="YIL130W" /coded_by="NM_001179478.1:1..2895" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]" /note="Zinc cluster protein proposed to be a transcriptional regulator; regulator involved in the stress response; regulates utilization of fatty acids and accumulation of lipids" /db_xref="GeneID:854676" /db_xref="SGD:S000001392" ORIGIN 1 mpeqaqqgeq svkrrrvtra cdecrkkkvk cdgqqpcihc tvysyectyk kptkrtqnsg 61 nsgvltlgnv ttgpssstvv aaaasnpnkl lsnikterai lpgastipas nnpskprkyk 121 tkstrlqski drykqifdev fpqlpdidnl dipvflqifh nfkrdsqsfl ddtvkeytli 181 vndssspiqp vlssnsknst pdeflpnmks dsnsassnre qdsvdtysni pvgreikiil 241 ppkaialqfv kstwehccvl lrfyhrpsfi rqldelyetd pnnytskqmq flplcyaaia 301 vgalfsksiv sndssrekfl qdegykyfia arkliditna rdlnsiqail mliiflqcsa 361 rlstcytyig vamrsalrag fhrklspnsg fspieiemrk rlfytiykld vyinamlglp 421 rsispddfdq tlpldlsden itevaylpen qhsvlsstgi snehtklfli lneiiselyp 481 ikktsniish etvtslelkl rnwldslpke lipnaenidp eyeranrllh lsflhvqiil 541 yrpfihylsr nmnaenvdpl cyrrarnsia vartviklak emvsnnlltg sywyacytif 601 ysvagllfyi heaqlpdkds areyydilkd aetgrsvliq lkdssmaasr tynllnqife 661 klnsktiqlt alhsspsnes aflvtnnssa lkphlgdslq ppvffssqdt knsfslakse 721 estndyaman ylnntpisen plneaqqqdq vsqgttnmsn erdpnnflsi dirldnngqs 781 nildatddvf irndgdiptn safdfsssks nasnnsnpdt innnynnvsg knnnnnnitn 841 nsnnnhnnnn ndnnnnnnnn nnnnnnnnns gnssnnnnnn nnnknnndfg ikidnnspsy 901 egfpqlqipl sqdnlniedk eemspnieik neqnmtdsnd ilgvfdqlda qlfgkylpln 961 ypse // LOCUS NP_012137 2376 aa linear PLN 30-JUN-2025 DEFINITION Tao3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012137 VERSION NP_012137.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179477.3 REFERENCE 1 (residues 1 to 2376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2376) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 2376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08424. On Jul 30, 2012 this sequence version replaced NP_012137.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..2376 /product="Tao3p" /calculated_mol_wt="269728" Region 348..887 /region_name="MOR2-PAG1_N" /note="Cell morphogenesis N-terminal; pfam14222" /db_xref="CDD:464107" Region 936..1869 /region_name="MOR2-PAG1_mid" /note="Cell morphogenesis central region; pfam14228" /db_xref="CDD:433790" Region 1903..2153 /region_name="MOR2-PAG1_C" /note="Cell morphogenesis C-terminal; pfam14225" /db_xref="CDD:464109" CDS 1..2376 /gene="TAO3" /locus_tag="YIL129C" /gene_synonym="PAG1" /coded_by="NM_001179477.3:1..7131" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11854408]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12972564]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12972564]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0000902 cell morphogenesis [PMID:11854408]" /experiment="EXISTENCE:mutant phenotype:GO:0007114 cell budding [PMID:11854408]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:12972564]" /note="Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p" /db_xref="GeneID:854677" /db_xref="SGD:S000001391" ORIGIN 1 masrftfppq rdqgigftfp ptnkaegssn nnqisididp sgqdvleein eaplntfplh 61 qsvtdapiid ipsptdmseg tslnnqlllr qqqqqgtgeg qalpptfvee qsdqnkisml 121 lpeqkqqrmq esappditak svaedyvttl rqqmatdwks pseyalhilf tkfiryaenk 181 lnmclqqldm aeppiveilg egvdpsfdei ikslghiakk kpkpvidamm fwrktkseaa 241 nsaseemekl lkeyefekah psqahflmnr rlsrsssntt skykhnnntn nlpgmkrhvs 301 ssfnnkvpli kasssnnsat sspsiansql kslentieva keeafladrk slisiyilcr 361 vlneivkqas sneeedlsdk leeivftqlk ttdplsists likssnwnsf aellgsmsek 421 kflsvsdrfi adlekipayi ppelepsthl lilgmrylkl rnyplekfee sadfmkslsk 481 ffaktenfpv clayaevtnq lllplagslt aevnhptwve amstllntak rlqadskywv 541 sgfkltvsil casppdlfsk qwlslleana skvkskslne riifavglsr lvwvylyrcp 601 etlnnttrtl tkllqlylnt rkkenwitgd fgllnpltda lisigflhpn flmeqalipl 661 irqsfngsnl eninyeklil tintykgllv tkerprfped dnrlyelnln nitvnqvqea 721 ssinhteisd yfyklfllld ssigsevwsp enqhqkqssn afspfgfsfs ndndssknks 781 lyvilfgtii eaipcclsis rtipykstie ilsrnavhse viissssqna lralaskknp 841 ytlitwfaky sfdfdektqs synmsylssk eynrllilyv ellecwleef qssnkeenkk 901 etgldgirll pidaeqeesn eteklewknt vtvieevegn glfflcshda kirrlgiqil 961 riifkfdeam mekteklsng hsrssshfaa drgtrlidll necntttlin phkatlsave 1021 ktrfsrlnsk ykrgllikla eseygvdaal wqrafpklla lvfktcpmam alcrsivcir 1081 lvqvheiilr vandvdfklk nvlpetivnq wklyliaact sltstfdqkl hipsnipqhg 1141 rkksqqiftv qhqkiksaks ifkmvlplln akyimirdai itglssmnin ifkayveaid 1201 vflvawkegs snnqirvemf hiltilspyl ksdmifndew ilrklseflq ktkqflekds 1261 vqisyeyqsl rsyfaglils yymavrehpl idelfpfqar ascfnflkew cgygeyepis 1321 eeryaimikn tesgrdrtai ttgiefqknr lqmivletmv vlcsdpitqt ldddlelpiv 1381 isfdtedlla wiealfdsdn ttvknlgvra lenlldknre nfklfrdvaf qcvshhshps 1441 vavlyyttlc ksvlkldnlv ldedelvslg lyglvadked trtfavdlls avetklhnss 1501 ytkvfkerla nssktvykst akeissifae llsqdlclri fsslvrildl fpfeikrdll 1561 vlmvpwvnkf tlksleeldt fmvlnnlfyi tidlndslpn eveqlwislg kgnsfqnihv 1621 sleyiinssm nhcnplfvqy ardivlylan ipggiglldt llnnlepkym vplakhtfne 1681 pmnnnkysfl gniwerlnyn gkriifskaq lsiiflvnll tnlsesvkak iplllhmsic 1741 lldhyvplih esackiastl ifglapshek seetvkllrn khalwsydnl mkkgarspkt 1801 mdllirniis ifsdldefqv twqrialkwa ttcsvrhiac rsfqifrsll tfldqemlrd 1861 mlhrlsntis dgnvdiqgfa mqilmtlnai maeldptnli sfpqlfwsit aclssiheqe 1921 fievlsclsk fiskidldsp dtvqclvaif psnwegrfdg lqqivmtglr sansleitwk 1981 fldklnllkd sriiantesr llfalianlp rflnamdrkd ftgiqvaads lielanaykq 2041 pslsrlidsl aknkfrskkd fmsqvvsfis rnyfpsysaq tlvfllgllf nkigwirvqt 2101 leilkyvfpl idlrrpefig vgadlispll rllfteyeak alevldcvpn vsgskmdkdv 2161 lritmgnkdv kdgdnatttl fglpedsgws vpmptmtaat trhnvhavfm tcgtgksdev 2221 sahgsddmda viefhadgdy elgrmdtive fhadgdydlg rmdtndsisv aeekdaslsh 2281 mwaeldnlds fftkdtnvpn isskmgmgip hgrsdsiett rtdqtfsfes apqlydkkvs 2341 vilnrslsrt psnvsfkthl adsfavkinr ngkpri // LOCUS NP_012138 1032 aa linear PLN 30-JUN-2025 DEFINITION Met18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012138 VERSION NP_012138.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179476.1 REFERENCE 1 (residues 1 to 1032) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1032) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1032) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1032) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1032) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1032) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1032) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08425. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1032 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1032 /product="Met18p" /calculated_mol_wt="117752" Region 49..313 /region_name="MMS19_N" /note="Dos2-interacting transcription regulator of RNA-Pol-II; pfam14500" /db_xref="CDD:433995" Region 577..982 /region_name="MMS19_C" /note="RNAPII transcription regulator C-terminal; pfam12460" /db_xref="CDD:463594" CDS 1..1032 /gene="MET18" /locus_tag="YIL128W" /gene_synonym="MMS19" /coded_by="NM_001179476.1:1..3099" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0097361 cytosolic [4Fe-4S] assembly targeting complex [PMID:22678362]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:22678362]" /note="Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Cia2p that directs Fe-S cluster incorporation and maturation of a subset of cytosolic and nuclear proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human MMS19" /db_xref="GeneID:854678" /db_xref="SGD:S000001390" ORIGIN 1 mtpdelnsav vtfmanlnid dskanetast vtdsivhrsi kllevvvalk dyflseneve 61 rkkaltcltt ilaktpkdhl sknecsvifq fyqsklddqa lakevlegfa alapmkyvsi 121 neiaqllrll ldnyqqgqhl astrlwpfki lrkifdrffv ngssteqvkr indlfietfl 181 hvangekdpr nlllsfalnk sitsslqnve nfkedlfdvl fcyfpitfkp pkhdpykisn 241 qdlktalrsa itatplfaed aysnlldklt asspvvkndt lltllecvrk fggssilenw 301 tllwnalkfe imqnsegnen tllnpynkdq qsddvgqytn ydaclkiinl malqlynfdk 361 vsfekffthv ldelkpnfky ekdlkqtcqi lsaigsgnve ifnkvisstf plflintsev 421 aklkllimnf sffvdsyidl fgrtskeslg tpvpnnkmae ykdeiimils maltrsskae 481 vtirtlsviq ftkmikmkgf ltpeevslii qyfteeiltd nnkniyyacl eglktiseiy 541 edlvfeislk klldllpdcf eekirvndee nihietilki ildfttsrhi lvkesitfla 601 tklnrvakis ksreycflli stiyslfnnn nqnenvlnee dalalknaie pklfeiitqe 661 saivsdnynl tllsnvlfft nlkipqaahq eeldrynelf isegkirild tpnvlaisya 721 kilsalnknc qfpqkftvlf gtvqllkkha prmteteklg ylelllvlsn kfvsekdvig 781 lfdwkdlsvi nlevmvwltk glimqnsles seiakkfidl lsneeigslv sklfevfvmd 841 isslkkfkgi swnnnvkily kqkffgdifq tlvsnykntv dmtikcnylt alslvlkhtp 901 sqsvgpfind lfplllqald mpdpevrvsa letlkdttdk hhtlitehvs tivplllsls 961 lphkynsvsv rlialqllem ittvvplnyc lsyqddvlsa lipvlsdkkr iirkqcvdtr 1021 qvyyelgqip fe // LOCUS NP_012139 206 aa linear PLN 30-JUN-2025 DEFINITION Rrt14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012139 VERSION NP_012139.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179475.1 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08426. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..206 /product="Rrt14p" /calculated_mol_wt="23714" Region 6..196 /region_name="RRT14" /note="Regular of rDNA transcription protein 14; pfam17075" /db_xref="CDD:374974" CDS 1..206 /gene="RRT14" /locus_tag="YIL127C" /coded_by="NM_001179475.1:1..621" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /note="hypothetical protein; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis" /db_xref="GeneID:854679" /db_xref="SGD:S000001389" ORIGIN 1 mssslsqtsk yqatsvvngl lsnllpgvpk iranngktsv nngskaqlid rnlkkrvqlq 61 nrdvhkikkk cklvkkkkvk khkldkeqle qlakhqvlkk hqhegtltdh erkylnklik 121 rnsqnlrswd leeevrdele diqqsilkdt vstantdrsk rrrfkrkqfk edikesdfvk 181 dhrypgltpg lapvglsdee dsseed // LOCUS NP_012140 1359 aa linear PLN 30-JUN-2025 DEFINITION RSC chromatin remodeling complex ATPase subunit STH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012140 VERSION NP_012140.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179474.1 REFERENCE 1 (residues 1 to 1359) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1359) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1359) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1359) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08427. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1359 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1359 /product="RSC chromatin remodeling complex ATPase subunit STH1" /EC_number="3.6.4.12" /calculated_mol_wt="156612" Region 312..378 /region_name="HSA" /note="HSA domain; pfam07529" /db_xref="CDD:462194" Region 370..>955 /region_name="PLN03142" /note="Probable chromatin-remodeling complex ATPase chain; Provisional" /db_xref="CDD:215601" Region 1006..1069 /region_name="SnAC" /note="Snf2-ATP coupling, chromatin remodelling complex; pfam14619" /db_xref="CDD:464219" Region <1211..>1359 /region_name="COG5076" /note="Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]" /db_xref="CDD:227408" CDS 1..1359 /gene="STH1" /locus_tag="YIL126W" /gene_synonym="NPS1" /coded_by="NM_001179474.1:1..4080" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1549132|PMID:1396591]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:8980231]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0015616 DNA translocase activity [PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:12183366|PMID:10619019]" /experiment="EXISTENCE:direct assay:GO:0140015 histone H3K14ac reader activity [PMID:20126658]" /experiment="EXISTENCE:direct assay:GO:0140054 histone H2A reader activity [PMID:20126658]" /experiment="EXISTENCE:direct assay:GO:0140658 ATP-dependent chromatin remodeler activity [PMID:12183366|PMID:9799253]" /experiment="EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:12697820]" /experiment="EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:24674626]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16024655]" /experiment="EXISTENCE:mutant phenotype:GO:0007010 cytoskeleton organization [PMID:12072455]" /experiment="EXISTENCE:mutant phenotype:GO:0031055 chromatin remodeling at centromere [PMID:12697820]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:10320476]" /note="ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; promotes base excision repair in chromatin; essential helicase-related protein homologous to Snf2p" /db_xref="GeneID:854680" /db_xref="SGD:S000001388" ORIGIN 1 mlqeqselms tvmnntpttv aalaavaaas etngklgsee qpeitipkpr ssaqleqlly 61 ryraiqnhpk enkleikaie dtfrnisrdq diyetkldtl rksidkgfqy dedllnkhlv 121 alqllekdtd vpdyfldlpd tkndnttaie vdysekkpik isadfnakak slgleskfsn 181 atktalgdpd teirisaris nrinelerlp anlgtysldd clefitkddl ssrmdtfkik 241 alvelkslkl ltkqksirqk linnvasqah hnipylrdsp ftaaaqrsvq irskvivpqt 301 vrlaeelerq qllekrkker nlhlqkinsi idfikerqse qwsrqercfq fgrlgaslhn 361 qmekdeqkri ertakqrlaa lksndeeayl klldqtkdtr itqllrqtns fldslseavr 421 aqqneakilh geevqpitde erektdyyev ahrikekidk qpsilvggtl keyqlrglew 481 mvslynnhln gilademglg ktiqsislit ylyevkkdig pflvivplst itnwtlefek 541 wapslntiiy kgtpnqrhsl qhqirvgnfd vllttyeyii kdksllskhd wahmiidegh 601 rmknaqskls ftishyyrtr nrliltgtpl qnnlpelwal lnfvlpkifn saktfedwfn 661 tpfantgtqe klelteeetl liirrlhkvl rpfllrrlkk evekdlpdkv ekvikcklsg 721 lqqqlyqqml khnalfvgag tegatkggik glnnkimqlr kicnhpfvfd evegvvnpsr 781 gnsdllfrva gkfelldrvl pkfkasghrv lmffqmtqvm dimedflrmk dlkymrldgs 841 tkteerteml nafnapdsdy fcfllstrag glglnlqtad tviifdtdwn phqdlqaqdr 901 ahrigqknev rilrlittds veevileram qkldidgkvi qagkfdnkst aeeqeaflrr 961 liesetnrdd ddkaelddde lndtlarsad ekilfdkidk ermnqerada kaqglrvppp 1021 rliqldelpk vfredieehf kkedseplgr irqkkrvyyd dglteeqfle aveddnmsle 1081 daikkrrear errrlrqngt keneietlen tpeasetsli ennsftaavd eetnadkett 1141 asrskrrssr kkrtisivta edkentqees tsqenggakv eeevksssve iingseskkk 1201 kpkltvkikl nkttvlennd gkraeekpes kspakktaak ktktkskslg ifptveklve 1261 emreqldevd shprtsifek lpskrdypdy fkviekpmai diilknckng tyktleevrq 1321 alqtmfenar fyneegswvy vdadklneft dewfkehss // LOCUS NP_012141 1014 aa linear PLN 30-JUN-2025 DEFINITION alpha-ketoglutarate dehydrogenase KGD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012141 VERSION NP_012141.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179473.1 REFERENCE 1 (residues 1 to 1014) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1014) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1014) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1014) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08428. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1014 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1014 /product="alpha-ketoglutarate dehydrogenase KGD1" /EC_number="1.2.4.2" /calculated_mol_wt="114286" Region 44..1011 /region_name="2oxo_dh_E1" /note="2-oxoglutarate dehydrogenase, E1 component; TIGR00239" /db_xref="CDD:161785" CDS 1..1014 /gene="KGD1" /locus_tag="YIL125W" /gene_synonym="OGD1" /coded_by="NM_001179473.1:1..3045" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048|PMID:11926067]" /experiment="EXISTENCE:direct assay:GO:0045252 oxoglutarate dehydrogenase complex [PMID:2072900]" /note="Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA" /db_xref="GeneID:854681" /db_xref="SGD:S000001387" ORIGIN 1 mlrfvssqtc ryssrgllkt sllknastvk ivgrglattg tdnflstsna tyidemyqaw 61 qkdpssvhvs wdayfknmsn pkipatkafq appsisnfpq gteaaplgta mtgsvdenvs 121 ihlkvqllcr ayqvrghlka hidplgisfg snknnpvppe ltldyygfsk hdldkeinlg 181 pgilprfard gkskmslkei vdhleklycs sygvqythip skqkcdwlre rieipepyqy 241 tvdqkrqild rltwatsfes flstkfpndk rfgleglesv vpgiktlvdr svelgvediv 301 lgmahrgrln vlsnvvrkpn esifsefkgs sarddiegsg dvkyhlgmny qrpttsgkyv 361 nlslvanpsh lesqdpvvlg rtrallhakn dlkektkalg vllhgdaafa gqgvvyetmg 421 fltlpeystg gtihvitnnq igfttdprfa rstpypsdla kaidapifhv nandveavtf 481 ifnlaaewrh kfhtdaiidv vgwrkhghne tdqpsftqpl mykkiakqks vidvytekli 541 segtfskkdi dehkkwvwnl fedafekakd yvpsqrewlt aawegfkspk elateilphe 601 ptnvpestlk elgkvlsswp egfevhknlk rilknrgksi etgegidwat gealafgtlv 661 ldgqnvrvsg edvergtfsq rhavlhdqqs eaiytplstl nnekadftia nsslseygvm 721 gfeygyslts pdylvmweaq fgdfantaqv iidqfiagge qkwkqrsglv lslphgydgq 781 gpehssgrle rflqlanedp ryfpseeklq rqhqdcnfqv vypttpanlf hilrrqqhrq 841 frkplalffs kqllrhplar sslseftegg fqwiiedieh gksigtkeet krlvllsgqv 901 ytalhkrres lgdkttaflk ieqlhpfpfa qlrdslnsyp nleeivwcqe eplnmgsway 961 teprlhttlk etdkykdfkv rycgrnpsga vaagskslhl aeedaflkdv fqqs // LOCUS NP_012142 297 aa linear PLN 30-JUN-2025 DEFINITION acylglycerone-phosphate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012142 VERSION NP_012142.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179472.3 REFERENCE 1 (residues 1 to 297) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 297) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 297) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 297) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08429. On Jul 30, 2012 this sequence version replaced NP_012142.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..297 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..297 /product="acylglycerone-phosphate reductase" /EC_number="1.1.1.101" /EC_number="3.1.1.3" /calculated_mol_wt="32683" Region 10..256 /region_name="17beta-HSD-like_SDR_c" /note="17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; cd05374" /db_xref="CDD:187632" Site order(16,18..21,41,63..65,93..96,116,142..144,157,161,190, 192..194) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:187632" Site order(117,144,157,161) /site_type="active" /db_xref="CDD:187632" Site order(144..146,151,157,188..189,195,206,211,256) /site_type="other" /note="steroid binding site" /db_xref="CDD:187632" CDS 1..297 /gene="AYR1" /locus_tag="YIL124W" /gene_synonym="GBG1" /coded_by="NM_001179472.3:1..894" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:24187129]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10617610|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10617610|PMID:24868093]" /experiment="EXISTENCE:genetic interaction:GO:0004806 triacylglycerol lipase activity [PMID:24187129]" /experiment="EXISTENCE:genetic interaction:GO:0019433 triglyceride catabolic process [PMID:24187129]" /experiment="EXISTENCE:mutant phenotype:GO:0000140 acylglycerone-phosphate reductase (NADP+) activity [PMID:10617610]" /experiment="EXISTENCE:mutant phenotype:GO:0004806 triacylglycerol lipase activity [PMID:24187129]" /experiment="EXISTENCE:mutant phenotype:GO:0006654 phosphatidic acid biosynthetic process [PMID:10617610]" /note="Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase; NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase involved in phosphatidic acid biosynthesis; lipid droplet triacylglycerol lipase involved in mobilization of non-polar lipids; found in lipid particles, endoplasmic reticulum and mitochondrial outer membrane; forms NADPH-regulated channel in mitochondrial outer membrane; required for spore germination; role in cell wall biosynthesis; capable of metabolizing steroid hormones" /db_xref="GeneID:854682" /db_xref="SGD:S000001386" ORIGIN 1 mselqsqpkk iavvtgasgg igyevtkela rngylvyaca rrlepmaqla iqfgndsikp 61 ykldiskpee ivtfsgflra nlpdgkldll ynnagqsctf paldatdaav eqcfkvnvfg 121 hinmcrelse flikakgtiv ftgslagvvs fpfgsiysas kaaihqyarg lhlemkpfnv 181 rvinaitggv atdiadkrpl petsiynfpe greafnsrkt makdnkpmpa dayakqlvkd 241 ilstsdpvdv yrgtfanimr fvmifvpywl lekglskkfk ldkvnnalks kqknkdd // LOCUS NP_012143 476 aa linear PLN 30-JUN-2025 DEFINITION putative glucosidase SIM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012143 VERSION NP_012143.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179471.2 REFERENCE 1 (residues 1 to 476) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 476) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 476) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 476) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08430. On Apr 26, 2011 this sequence version replaced NP_012143.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..476 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..476 /product="putative glucosidase SIM1" /calculated_mol_wt="48059" Region 221..462 /region_name="SUN" /note="Beta-glucosidase (SUN family); pfam03856" /db_xref="CDD:427547" CDS 1..476 /gene="SIM1" /locus_tag="YIL123W" /coded_by="NM_001179471.2:1..1431" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11958935]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:15972461]" /note="Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog, SUN4, that arose from the whole genome duplication" /db_xref="GeneID:854683" /db_xref="SGD:S000001385" ORIGIN 1 mkfstavttl issgaivsal phvdvhqeda hqhkravayk yvyetvvvds dghtvtpaas 61 evataatsai ittsvlapts saaaadssas iavssaalak nekisdaaas atastsqgas 121 sssssssats tlesssvsss seeaaptstv vstssatqss assatkssts stspststst 181 stsstsssss ssssssssss gsgsiygdla dfsgpsekfq dgtipcdkfp sgqgvisidw 241 igeggwsgve ntdtstggsc kegsycsysc qpgmsktqwp sdqpsdgrsv ggllckngyl 301 yrsntdadyl cewgveaayv vsklskgvai crtdypgten mviptyvegg sslpltvvdq 361 dtyftwegkk tsaqyyvnna gvsvedgciw gtsgsgignw aplnfgagst ggvtylslip 421 npnnsdalny nvkivaadds snvigecvye ngefsggadg ctvsvtsgka hfvlyn // LOCUS NP_012144 351 aa linear PLN 30-JUN-2025 DEFINITION Pog1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012144 VERSION NP_012144.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179470.1 REFERENCE 1 (residues 1 to 351) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 351) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 351) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 351) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08431. Method: conceptual translation. FEATURES Location/Qualifiers source 1..351 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..351 /product="Pog1p" /calculated_mol_wt="39367" CDS 1..351 /gene="POG1" /locus_tag="YIL122W" /coded_by="NM_001179470.1:1..1056" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:22959267]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:22959267]" /experiment="EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:9927449]" /experiment="EXISTENCE:mutant phenotype:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:9927449]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:22959267]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9927449|PMID:22959267]" /note="DNA-binding transcriptional activator; involved in cell cycle regulation; overexpression promotes recovery from pheromone induced arrest via CLN1/2 transcription, induction of of IME1 during sporulation, and suppression of stress sensitivity resulting from mutation of the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cycle-related genes; phosphorylated form may be ubiquitinated by Dma2p; potential Cdc28p substrate; regulated by Swi4/6 cell-cycle box binding factor (SBF)" /db_xref="GeneID:854684" /db_xref="SGD:S000001384" ORIGIN 1 mkqephrqse ekekpkgpma vereqhtsls sgttvtastg destnsrpve ssqtekslsl 61 ririlkqlgf ddiqelnacd tglveqflnv rlindtkele kiresnlakl nqiidkcmes 121 dkisdstlnk ildmsmnrdt nndnnnhlti pspittkkrk inaselaspr ghrryrsdip 181 tvsevetgvg ypqihqqpga ytlpmpanqw msnpymqppq pqvqqimpqy lyppgmgpqa 241 qlptmssnse sqtpvmssqf lslnqhglyq qnigahpvms mgpqaniygq qhqlqpgqer 301 dqsrksfshr rsqsanisma nfrspmrnpq passqrpvnf lihtpkhppp t // LOCUS NP_012145 542 aa linear PLN 30-JUN-2025 DEFINITION cation transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_012145 VERSION NP_012145.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179469.1 REFERENCE 1 (residues 1 to 542) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 542) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 542) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 542) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08432. Method: conceptual translation. FEATURES Location/Qualifiers source 1..542 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..542 /product="cation transporter" /calculated_mol_wt="59487" Region 64..530 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(74..75,78..79,82,114,164..165,167..169,172,192, 195..196,199,308,311..312,315..317,320,344,348,451..452, 456,460,475,478..479,482..483,486) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..542 /gene="QDR2" /locus_tag="YIL121W" /coded_by="NM_001179469.1:1..1629" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:34887841|PMID:15215105]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:1990573 potassium ion import across plasma membrane [PMID:17189489]" /experiment="EXISTENCE:mutant phenotype:GO:0008324 monoatomic cation transmembrane transporter activity [PMID:23106982]" /experiment="EXISTENCE:mutant phenotype:GO:0015565 threonine efflux transmembrane transporter activity [PMID:34887841]" /experiment="EXISTENCE:mutant phenotype:GO:0032973 amino acid export across plasma membrane [PMID:34887841]" /experiment="EXISTENCE:mutant phenotype:GO:0042910 xenobiotic transmembrane transporter activity [PMID:15215105|PMID:15649438]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:15649438|PMID:15215105]" /experiment="EXISTENCE:mutant phenotype:GO:0060003 copper ion export [PMID:23106982]" /experiment="EXISTENCE:mutant phenotype:GO:1990573 potassium ion import across plasma membrane [PMID:17189489]" /note="Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; exports copper; has broad substrate specificity and can transport many mono- and divalent cations; transports a variety of drugs and is required for resistance to quinidine, barban, cisplatin, and bleomycin; contributes to potassium homeostasis; expression is regulated by copper" /db_xref="GeneID:854685" /db_xref="SGD:S000001383" ORIGIN 1 magatssiir endfedelae smqsynreta dklaltrtes vkpepeitap phsrfsrsfk 61 tvliaqcaft gffstiagai yypvlsvier kfdideelvn vtvvvyfvfq glaptfmggf 121 adslgrrpvv lvaiviyfga ciglacaqty aqiivlrclq aagispviai nsgimgdvtt 181 raerggyvgy vagfqvlgsa fgaligagls srwgwraifw flaigsgicf lasflilpet 241 krnisgngsv tpksylnrap ilvlptvrks lhldnpdyet lelptqlnll apfkilkaye 301 icilmlvagl qfamytthlt alstalskqy hltvakvglc ylpsgictlc siviagryln 361 wnyrrrlkyy qnwlgkkrsk lleehdndln lvqriiendp kytfnifkar lqpafvtlll 421 sssgfcaygw citvkaplaa vlcmsgfasl fsnciltfst tlivdlfptk tstatgclnl 481 frcilsavfi aalskmvekm kfggvftflg altssssill fillrkgkel afkrkkqelg 541 vn // LOCUS NP_012146 563 aa linear PLN 30-JUN-2025 DEFINITION multidrug transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_012146 VERSION NP_012146.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179468.1 REFERENCE 1 (residues 1 to 563) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 563) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 563) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 563) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08433. Method: conceptual translation. FEATURES Location/Qualifiers source 1..563 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..563 /product="multidrug transporter" /calculated_mol_wt="61628" Region 72..516 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(82..83,86..87,90,122,172..173,175..177,180,200, 203..204,207,316,319..320,323..325,328,352,356,459..460, 464,468,483,486..487,490..491,494) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..563 /gene="QDR1" /locus_tag="YIL120W" /coded_by="NM_001179468.1:1..1692" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11302822]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]" /experiment="EXISTENCE:mutant phenotype:GO:0015562 efflux transmembrane transporter activity [PMID:15649438]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:15649438]" /note="Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; involved in spore wall assembly; sequence similarity to DTR1 and QDR3, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; required for resistance to quinidine, ketoconazole, fluconazole, and barban; QDR1 has a paralog, AQR1, that arose from the whole genome duplication" /db_xref="GeneID:854686" /db_xref="SGD:S000001382" ORIGIN 1 mtkqqtsvmr nasiakeere gsdnnnvdrs ssdaisdnda ersnshseid nesnfdmvpy 61 srfshkqkml lvvqcaftgf fstvagsiyy pvltiierkf niteelanvt ivvyfifqgv 121 apsimgglad tfgrrpivlw ailayfcaci glacahnyaq ilalrclqaa gispviains 181 gimgdvttkv erggyvglva gfqvvgtafg aligaglssk wgwraifwfl aigsgiclvf 241 stllmpetkr tlvgngsvtp rsflnrslil hvgsvkktlh lddpdpetle prtsvdflap 301 lkilhireid illsiaglqf stwtthqtal tivlskkynl svakiglcfl pagistltsi 361 isagrylnws yrtrkvkynr wikeqelqlm ekykgdknkv aelihsnshy afnlvearlh 421 pafvtlllss igftafgwci svktplaavl ctsafaslfs nciltfsttl ivdlfpskas 481 tatgclnlfr cllsaifiaa ltkmvekmry ggvftflsai tsssslllfy llkngkqlsf 541 drirandksa grsvgknsek vst // LOCUS NP_012147 407 aa linear PLN 30-JUN-2025 DEFINITION Rpi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012147 VERSION NP_012147.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179467.3 REFERENCE 1 (residues 1 to 407) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 407) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 407) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08434. On Jul 30, 2012 this sequence version replaced NP_012147.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..407 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..407 /product="Rpi1p" /calculated_mol_wt="46492" Region 95..>157 /region_name="Myb_DNA-bind_4" /note="Myb/SANT-like DNA-binding domain; pfam13837" /db_xref="CDD:463994" CDS 1..407 /gene="RPI1" /locus_tag="YIL119C" /coded_by="NM_001179467.3:1..1224" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12455971]" /experiment="EXISTENCE:genetic interaction:GO:0009272 fungal-type cell wall biogenesis [PMID:12455971]" /experiment="EXISTENCE:mutant phenotype:GO:0007265 Ras protein signal transduction [PMID:1649384]" /experiment="EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:12455971]" /experiment="EXISTENCE:mutant phenotype:GO:0030695 GTPase regulator activity [PMID:1649384]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12455971]" /note="Transcription factor, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF" /db_xref="GeneID:854687" /db_xref="SGD:S000001381" ORIGIN 1 myleylqpkl nlmdesstis knfpdyspnl ntpitsnfne etgsdcslvt priisssnsn 61 snsnsnsnsn snsgsidene lnnsnsssss arqirkkwke pediafitti mnnsqlltfv 121 eyfkpmknfw kkiskilfqq ygyernsrqc hdrfkvlytk slkvhpskks kqkkkkskqe 181 agsnlnfdps klsrmqyllv qlqntfsfvn gniilksqkt lkpnkngtnd ninnhyynnc 241 nnnnnninns nnsnnnnsnn inrnsnhstn vfstpehiqs sinldklesl paldtkgeps 301 fispaqfsll ssapadnlil qtppspffqq tmpiqlprda qqeqispvfs tdviymwqtm 361 fntienlkeq vnclknevkq lnhkfyqqnk plhnmstsds enfmqqh // LOCUS NP_012148 231 aa linear PLN 30-JUN-2025 DEFINITION Rho family GTPase RHO3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012148 VERSION NP_012148.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179466.1 REFERENCE 1 (residues 1 to 231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 231) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08435. Method: conceptual translation. FEATURES Location/Qualifiers source 1..231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..231 /product="Rho family GTPase RHO3" /calculated_mol_wt="25181" Region 17..231 /region_name="Rho3" /note="Ras homology family 3 (Rho3) of small guanosine triphosphatases (GTPases); cd04134" /db_xref="CDD:206706" Site order(18,48..49,52..53,55,57,65,69..70,72..74,80,83) /site_type="other" /note="putative GEF (guanine nucleotide exchange factor) interaction site [polypeptide binding]" /db_xref="CDD:206706" Site 23..30 /site_type="other" /note="G1 box" /db_xref="CDD:206706" Site order(26..31,70..71,73,129,131,193..194) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206706" Site 47..53 /site_type="other" /note="Switch I region" /db_xref="CDD:206706" Site 48 /site_type="other" /note="G2 box" /db_xref="CDD:206706" Site order(49,72,80,82) /site_type="active" /note="putative GDI (guanine nucleotide dissociation inhibitor) interaction [active]" /db_xref="CDD:206706" Site order(49..50,74,80) /site_type="other" /note="putative GAP (GTPase-activating protein) interaction site [polypeptide binding]" /db_xref="CDD:206706" Site order(50..51,80,83) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206706" Site 70..73 /site_type="other" /note="G3 box" /db_xref="CDD:206706" Site order(73..74,80..83,88..90) /site_type="other" /note="Switch II region" /db_xref="CDD:206706" Site 128..131 /site_type="other" /note="G4 box" /db_xref="CDD:206706" Site 192..194 /site_type="other" /note="G5 box" /db_xref="CDD:206706" Site 228..231 /site_type="other" /note="putative lipid modification site [posttranslational modification]" /db_xref="CDD:206706" CDS 1..231 /gene="RHO3" /locus_tag="YIL118W" /coded_by="NM_001179466.1:1..696" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:10526184]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:10207081]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10207081]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:10207081]" /experiment="EXISTENCE:genetic interaction:GO:0045921 positive regulation of exocytosis [PMID:8852836|PMID:19955214]" /experiment="EXISTENCE:genetic interaction:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:12810699]" /experiment="EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:10588647|PMID:8852836]" /experiment="EXISTENCE:mutant phenotype:GO:0045921 positive regulation of exocytosis [PMID:10588647]" /experiment="EXISTENCE:mutant phenotype:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:12810699]" /experiment="EXISTENCE:physical interaction:GO:0045921 positive regulation of exocytosis [PMID:19955214]" /note="Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p" /db_xref="GeneID:854688" /db_xref="SGD:S000001380" ORIGIN 1 msflcgsast snkpierkiv ilgdgacgkt sllnvftrgy fpevyeptvf enyihdifvd 61 skhitlslwd tagqeefdrl rslsysdtqc imlcfsidsr dslenvqnkw vgeitdhceg 121 vklvlvalkc dlrnnenesn aitpnniqqd nsvsndngnn instsngknl isyeeglama 181 kkigalryle csaklnkgvn eafteaarva ltagpvatev ksdsgsscti m // LOCUS NP_012149 318 aa linear PLN 30-JUN-2025 DEFINITION pheromone-regulated protein PRM5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012149 VERSION NP_012149.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179465.1 REFERENCE 1 (residues 1 to 318) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 318) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 318) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 318) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08436. Method: conceptual translation. FEATURES Location/Qualifiers source 1..318 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..318 /product="pheromone-regulated protein PRM5" /calculated_mol_wt="34520" CDS 1..318 /gene="PRM5" /locus_tag="YIL117C" /coded_by="NM_001179465.1:1..957" /note="Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling; PRM5 has a paralog, YNL058C, that arose from the whole genome duplication" /db_xref="GeneID:854689" /db_xref="SGD:S000001379" ORIGIN 1 mtvitiakrg lpklttstss tttassssti tsvasssssl pllsnstsss iipsitppsr 61 ngnpyildsg dmpngtvfiv vggiagvifl aillwwvitt ysshrltrsv qdyeskmfst 121 qhtqfygdsp ymdypakenf qdqvhisesd ispgnkdesv kdalvshtnn ekpflsnfer 181 plfslasesn rnslfisptg dilyktrlsk lyqesprllq kpvimtsdnv stnslvstis 241 sssassldng nekevgedir kpakiassps rkllnspesd gsvnrnhskg nllvvqskrk 301 ptpstylehm legkeqde // LOCUS NP_012150 385 aa linear PLN 30-JUN-2025 DEFINITION histidinol-phosphate transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012150 VERSION NP_012150.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179464.1 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08437. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..385 /product="histidinol-phosphate transaminase" /EC_number="2.6.1.9" /calculated_mol_wt="42515" Region 10..377 /region_name="hisC" /note="histidinol-phosphate aminotransferase; TIGR01141" /db_xref="CDD:273467" CDS 1..385 /gene="HIS5" /locus_tag="YIL116W" /coded_by="NM_001179464.1:1..1158" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000105 L-histidine biosynthetic process [PMID:14190241]" /experiment="EXISTENCE:mutant phenotype:GO:0004400 histidinol-phosphate transaminase activity [PMID:14190241]" /note="Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts" /db_xref="GeneID:854690" /db_xref="SGD:S000001378" ORIGIN 1 mvfdlkrivr pkiynlepyr carddftegi lldanenahg ptpvelsktn lhrypdphql 61 efktamtkyr nktssyandp evkpltadnl clgvgsdesi daiiraccvp gkekilvlpp 121 tysmysvcan indievvqcp ltvsdgsfqm dteavltilk ndsliklmfv tspgnptgak 181 iktsliekvl qnwdnglvvv deayvdfcgg staplvtkyp nlvtlqtlsk sfglagirlg 241 mtyataelar ilnamkapyn isslaseyal kavqdsnlkk meatskiine ekmrllkelt 301 aldyvddqyv ggldanflli ringgdnvla kklyyqlatq sgvvvrfrgn elgcsgclri 361 tvgtheenth likyfketly klane // LOCUS NP_012151 1460 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin NUP159 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012151 VERSION NP_012151.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179463.1 REFERENCE 1 (residues 1 to 1460) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1460) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1460) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1460) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08438. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1460 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1460 /product="FG-nucleoporin NUP159" /calculated_mol_wt="158777" Region 24..380 /region_name="NUP214" /note="Nucleoporin or Nuclear pore complex subunit NUP214=Nup159; pfam16755" /db_xref="CDD:407023" Region <448..700 /region_name="Herpes_BLLF1" /note="Herpes virus major outer envelope glycoprotein (BLLF1); pfam05109" /db_xref="CDD:282904" Region <558..>874 /region_name="PTZ00395" /note="Sec24-related protein; Provisional" /db_xref="CDD:185594" Region 751..>1006 /region_name="PRK08581" /note="amidase domain-containing protein" /db_xref="CDD:236304" CDS 1..1460 /gene="NUP159" /locus_tag="YIL115C" /gene_synonym="NUP158; RAT7" /coded_by="NM_001179463.1:1..4383" /experiment="EXISTENCE:direct assay:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:21576266]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:7642562|PMID:7744966|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:14960378|PMID:10684247]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]" /experiment="EXISTENCE:genetic interaction:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:10952996]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906|PMID:11739405]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:11739405]" /experiment="EXISTENCE:mutant phenotype:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:21576266]" /experiment="EXISTENCE:mutant phenotype:GO:0006405 RNA export from nucleus [PMID:11352936]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:17347149]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:15574330|PMID:7744966|PMID:9359887|PMID:9802895|PMID :27385342]" /experiment="EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:7744966|PMID:9359887]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788]" /note="FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)" /db_xref="GeneID:854691" /db_xref="SGD:S000001377" ORIGIN 1 msslkdevpt etsedfgfkf lgqkqilpsf neklpfaslq nldisnsksl fvaasgskav 61 vgelqllrdh itsdstpltf kwekeipdvi fvcfhgdqvl vstrnalysl dleelsefrt 121 vtsfekpvfq lknvnntlvi lnsvndlsal dlrtkstkql aqnvtsfdvt nsqlavllkd 181 rsfqsfawrn gemekqfefs lpseleelpv eeysplsvti lspqdflavf gnvisetdde 241 vsydqkmyii khidgsasfq etfditppfg qivrfpymyk vtlsgliepd anvnvlassc 301 ssevsiwdsk qviepsqdse ravlpiseet dkdtnpigva vdvvtsgtil epcsgvdtie 361 rlplvyilnn egslqivglf hvaaiksghy sinleslehe kslsptseki piagqeqeek 421 kknnesskal senpftsant sgftflktqp aaanslqsqs sstfgapsfg ssafkidlps 481 vsststgvas seqdatdpas akpvfgkpaf gaiakepsts eyafgkpsfg apsfgsgkss 541 vespasgsaf gkpsfgtpsf gsgnssvepp asgsafgkps fgtpsfgsgn ssaeppasgs 601 afgkpsfgts afgtassnet nsgsifgkaa fgsssfapan nelfgsnfti skptvdspke 661 vdstspfpss gdqsedesks dvdssstpfg tkpntstkpk tnafdfgsss fgsgfskale 721 svgsdttfkf gtqaspfssq lgnkspfssf tkddtengsl skgstseind dneehesngp 781 nvsgndltds tveqtsstrl petpsdedge vveeeaqksp igkltetikk sanidmaglk 841 npvfgnhvka ksespfsafa tnitkpsstt pafsfgnstm nksntstvsp meeadtkets 901 ekgpitlksv enpflpakee rtgesskkdh nddpkdgyvs gseisvrtse safdttanee 961 ipksqdvnnh eksetdpkys qhavvdhdnk skemnetskn nersgqpnhg vqgdgialkk 1021 dnekenfdsn maikqfedhq sseedasekd srqssevkes ddnmslnsdr desisesydk 1081 ledintdelp hggeafkare vsasadfdvq tslednyaes giqtdlsess kenevqtdai 1141 pvkhnstqtv kkeavdnglq tepvetcnfs vqtfegdeny laeqckpkql keyytsakvs 1201 nipfvsqnst lrliestfqt veaeftvlme nirnmdtfft dqssiplvkr tvrsinnlyt 1261 wripeaeill niqnnikceq mqitnaniqd lkekvtdyvr kdiaqitedv anakeeylfl 1321 mhfddassgy vkdlsthqfr mqktlrqklf dvsakinhte ellnilklft vknkrlddnp 1381 lvaklakesl ardgllkeik llreqvsrlq leekgkkass fdasssitkd mkgfkvvevg 1441 lamntkkqig dffknlnmak // LOCUS NP_012152 281 aa linear PLN 30-JUN-2025 DEFINITION putative porin POR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012152 VERSION NP_012152.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179462.3 REFERENCE 1 (residues 1 to 281) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 281) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 281) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 281) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08439. On Jul 30, 2012 this sequence version replaced NP_012152.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..281 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..281 /product="putative porin POR2" /calculated_mol_wt="31046" Region 6..280 /region_name="Porin3_VDAC" /note="Voltage-dependent anion channel of the outer mitochondrial membrane; cd07306" /db_xref="CDD:132767" Site order(15,19,46,61,84,151,280) /site_type="active" /note="putative determinants of voltage gating [active]" /db_xref="CDD:132767" Site order(27,29,255,257,275) /site_type="other" /note="putative dimerization interface [polypeptide binding]" /db_xref="CDD:132767" CDS 1..281 /gene="POR2" /locus_tag="YIL114C" /coded_by="NM_001179462.3:1..846" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:11914276|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:9315631]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:18768136]" /experiment="EXISTENCE:mutant phenotype:GO:0051027 DNA transport [PMID:19056337]" /note="Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication" /db_xref="GeneID:854692" /db_xref="SGD:S000001376" ORIGIN 1 malrffndis rdvnglfnrd ffhtnplsln istttengvn ftlkakqgvt egpiqtsveg 61 rfydrkegvs lsqswsnqnr lntriefski apgwkgdvna fltpqsikna kfnlsyaqks 121 faartsidil qpkdfvgsvt lghrgfvggt diaydtaagl caryamsigy lareysfils 181 tnnrqcatas ffqnvnrylq vgtkatlqsk tssnmniefv tryvpdsisq vkakiadsgl 241 ttlsykrnln kdislgvgms fnalqltepv hkfgwslsfs p // LOCUS NP_012153 209 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase tyrosine protein phosphatase SDP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012153 VERSION NP_012153.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179461.1 REFERENCE 1 (residues 1 to 209) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 209) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 209) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 209) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08440. Method: conceptual translation. FEATURES Location/Qualifiers source 1..209 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..209 /product="mitogen-activated protein kinase tyrosine protein phosphatase SDP1" /EC_number="3.1.3.48" /calculated_mol_wt="23754" Region 56..194 /region_name="DSP_fungal_SDP1-like" /note="dual specificity phosphatase domain of fungal dual specificity protein phosphatase SDP1, MSG5, and similar proteins; cd14521" /db_xref="CDD:350371" CDS 1..209 /gene="SDP1" /locus_tag="YIL113W" /coded_by="NM_001179461.1:1..630" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11923319]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11923319]" /experiment="EXISTENCE:direct assay:GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity [PMID:12220658]" /experiment="EXISTENCE:direct assay:GO:0033550 MAP kinase tyrosine phosphatase activity [PMID:11923319|PMID:17495930]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:11923319]" /note="Stress-inducible dual-specificity MAP kinase phosphatase; negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock; SDP1 has a paralog, MSG5, that arose from the whole genome duplication" /db_xref="GeneID:854693" /db_xref="SGD:S000001375" ORIGIN 1 mniytsptrt pniapksgqr pslpmlatde rstdkespne drefvpcssl dvrriypkgp 61 llvlpekiyl yseptvkell pfdvvinvae eandlrmqvp aveyhhyrwe hdsqialdlp 121 sltsiihaat tkrekilihc qcglsrsatl iiayimkyhn lslrhsydll ksradkinps 181 iglifqlmew evalnaktnv qansyrkvp // LOCUS NP_012154 1083 aa linear PLN 30-JUN-2025 DEFINITION Hos4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012154 VERSION NP_012154.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179460.1 REFERENCE 1 (residues 1 to 1083) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1083) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1083) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1083) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1083) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1083) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1083) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08441. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1083 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1083 /product="Hos4p" /calculated_mol_wt="123426" Region <325..>435 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 330..361 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(331,335..336,339..341,343..344,348,351,361,363,365, 369..370,373..375,377..378,382,385,396,398,400,404..405, 408..410,412..413,417,420,429) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 363..396 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 398..429 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 537..624 /region_name="Ank_2" /note="Ankyrin repeats (3 copies); pfam12796" /db_xref="CDD:463710" Region 592..624 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..1083 /gene="HOS4" /locus_tag="YIL112W" /coded_by="NM_001179460.1:1..3252" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:11711434]" /experiment="EXISTENCE:direct assay:GO:0034967 Set3 complex [PMID:11711434]" /note="Subunit of the Set3 complex; complex is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate" /db_xref="GeneID:854694" /db_xref="SGD:S000001374" ORIGIN 1 mnetttkqpl kkrslssyls nvstrreele kiskqetsee edtagkheqr etlseevsdk 61 fpenvasfrs qttsvhqatq nnlnakesed lahkndassh egevngdsrp ddvpetneki 121 sqairakiss sssspnvrnv diqnhqpfsr dqlramlkep krktvddfie eeglgaveee 181 dlsdevlekn ttepenvekd ieysdsdkdt ddvgsddpta pnspiklgrr klvrgdqlda 241 ttssmfnnes dselsdidds knialssslf rggsspvket nnnlsnmnss paqnpkrgsv 301 srsndsnkss hiavskrpkq kkgiyrdsgg rtrlqiacdk gkydvvkkmi eeggydindq 361 dnagntalhe aalqghieiv elliengadv niksiemfgd tplidasang hldvvkyllk 421 ngadptirna kgltafesvd desefddeed qkilreikkr lsiaakkwtn ragihndksk 481 ngnnahtidq ppfdnttkak nekaadspsm asnidekape eefywtdvts ragkeklfka 541 skeghlpyvg tyvenggkid lrsffesvkc gheditsifl afgfpvnqts rdnktsalmv 601 avgrghlgtv kllleagadp tkrdkkgrta lyyaknsimg itnseeiqli enainnylkk 661 hsednndddd dddnnnetyk hekkrektqs pilasrrsat priedeeddt rmlnladddf 721 nndrdvkest tsdsrkrldd nenvgtqysl dwkkrktnal qdeeklksis plsmephspk 781 kaksveiski heetaaerea rlkeeeeyrk krlekkrkke qellqklaed ekkrieeqek 841 qkvlemerle katlekarkm erekemeeis yrravrdlyp lglkiinfnd kldykrflpl 901 yyfvdekndk fvldlqvmil lkdidllskd nqptsekipv dpshltplwn mlkfiflygg 961 syddkknnme nkryvvnfdg vdldtkigye lleykkfvsl pmawikwdnv vienhakrke 1021 iegnmiqisi nefarwrndk lnkaqqptrk qrslkiprel pvkfqhrmsi ssvlqqtske 1081 pfw // LOCUS NP_012155 151 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c oxidase subunit Vb [Saccharomyces cerevisiae S288C]. ACCESSION NP_012155 VERSION NP_012155.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179459.1 REFERENCE 1 (residues 1 to 151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 151) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08442. Method: conceptual translation. FEATURES Location/Qualifiers source 1..151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..151 /product="cytochrome c oxidase subunit Vb" /calculated_mol_wt="17066" Region 18..151 /region_name="Cyt_c_Oxidase_IV" /note="Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cd00922" /db_xref="CDD:238462" Site order(20,102,113) /site_type="other" /note="Subunit IV/VIIIb interface [polypeptide binding]" /db_xref="CDD:238462" Site 24 /site_type="other" /note="Subunit IV/Vb interface [polypeptide binding]" /db_xref="CDD:238462" Site order(30,32,34..37,54,56,58,66,70..71,73..74,76..79,82) /site_type="other" /note="Subunit IV/Va interface [polypeptide binding]" /db_xref="CDD:238462" Site order(31..33,88,95,99,103,107,116,118,121..122) /site_type="other" /note="Subunit IV/I interface [polypeptide binding]" /db_xref="CDD:238462" Site order(32,133..134,137,141,143..145) /site_type="other" /note="Subunit IV/II interface [polypeptide binding]" /db_xref="CDD:238462" Site order(32,83,85,88..89) /site_type="other" /note="putative ATP/ADP binding site [chemical binding]" /db_xref="CDD:238462" Site order(90..91,97..98,100..102,104..105,122,125,128..129,132, 136,145,149) /site_type="other" /note="Subunit IV/VIIb interface [polypeptide binding]" /db_xref="CDD:238462" Site order(138,143) /site_type="other" /note="Subunit IV/VIc interface [polypeptide binding]" /db_xref="CDD:238462" CDS 1..151 /gene="COX5B" /locus_tag="YIL111W" /coded_by="NM_001179459.1:1..456" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0045277 respiratory chain complex IV [PMID:2986105]" /experiment="EXISTENCE:mutant phenotype:GO:0004129 cytochrome-c oxidase activity [PMID:2986105]" /experiment="EXISTENCE:mutant phenotype:GO:0050421 nitrite reductase (NO-forming) activity [PMID:18388202]" /note="Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication" /db_xref="GeneID:854695" /db_xref="SGD:S000001373" ORIGIN 1 mlrtsltkga rltgtrfvqt kalskatltd lperwenmpn leqkeiadnl terqklpwkt 61 lnneeikaaw yisygewgpr rpvhgkgdva fitkgvflgl gisfglfglv rllanpetpk 121 tmnrewqlks deylksknan pwggysqvqs k // LOCUS NP_012156 377 aa linear PLN 30-JUN-2025 DEFINITION protein-histidine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012156 VERSION NP_012156.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179458.1 REFERENCE 1 (residues 1 to 377) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 377) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 377) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 377) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08443. Method: conceptual translation. FEATURES Location/Qualifiers source 1..377 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..377 /product="protein-histidine N-methyltransferase" /EC_number="2.1.1.85" /calculated_mol_wt="42384" CDS 1..377 /gene="HPM1" /locus_tag="YIL110W" /gene_synonym="MNI1" /coded_by="NM_001179458.1:1..1134" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:24865971|PMID:26826131]" /experiment="EXISTENCE:mutant phenotype:GO:0018064 protein-L-histidine N-tele-methyltransferase activity [PMID:20864530]" /experiment="EXISTENCE:mutant phenotype:GO:0042038 peptidyl-histidine methylation, to form tele-methylhistidine [PMID:20864530]" /experiment="EXISTENCE:mutant phenotype:GO:0045903 positive regulation of translational fidelity [PMID:24865971]" /note="AdoMet-dependent methyltransferase; involved in a novel 3-methylhistidine modification of multiple proteins, including ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance" /db_xref="GeneID:854696" /db_xref="SGD:S000001372" ORIGIN 1 msfsfgftsn dfdddelvaq petfvesske nenttayinp ldsdflsqag vvqpnvedlg 61 tileslkdvr ltfeefqspi yrkplikrel fdvkhqlmle tdaqsnnnst eldillgdts 121 edlrkniyeg glkswecsyd lvdllsenvd risndidavv eigcgtalps eflfrsallr 181 ndrskglkfv ltdynasvlr lvtipnlvit waktvltkeq wyalqkdece dipinneell 241 ltskllaafy ddvqsrnisv tlisgswgrk fsnlihevls gsqkvlslss etiyqpdnlp 301 viaetildih nlpqtdvkty vaakdiyfgv ggsitefeay lddkinsehl pihserfkvn 361 sglkrsiici etnkair // LOCUS NP_012157 926 aa linear PLN 30-JUN-2025 DEFINITION COPII subunit SEC24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012157 VERSION NP_012157.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179457.3 REFERENCE 1 (residues 1 to 926) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 926) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 926) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 926) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 926) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 926) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 926) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08444. On Jul 30, 2012 this sequence version replaced NP_012157.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..926 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..926 /product="COPII subunit SEC24" /calculated_mol_wt="103505" Region 1..926 /region_name="COG5028" /note="Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]" /db_xref="CDD:227361" CDS 1..926 /gene="SEC24" /locus_tag="YIL109C" /gene_synonym="ANU1" /coded_by="NM_001179457.3:1..2781" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:8004676]" /experiment="EXISTENCE:direct assay:GO:0090110 COPII-coated vesicle cargo loading [PMID:15665868|PMID:14627716|PMID:12941277]" /experiment="EXISTENCE:mutant phenotype:GO:0005048 signal sequence binding [PMID:12941277]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11694599]" /note="Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SEC24 has a paralog, SFB2, that arose from the whole genome duplication" /db_xref="GeneID:854697" /db_xref="SGD:S000001371" ORIGIN 1 mshhkkrvyp qaqlqygqna tplqqpaqfm ppqdpaaagm sygqmgmppq gavpsmgqqq 61 fltpaqeqlh qqidqattsm ndmhlhnvpl vdpnaymqpq vpvqmgtplq qqqqpmaapa 121 ygqpsaamgq nmrpmnqlyp idlltelppp itdltlpppp lvippermlv pselsnaspd 181 yirstlnavp knssllkksk lpfglvirpy qhlyddidpp plnedglivr crrcrsymnp 241 fvtfieqgrr wrcnfcrlan dvpmqmdqsd pndpksrydr neikcavmey mapkeytlrq 301 pppatycfli dvsqssiksg llattintll qnldsipnhd ertrisilcv dnaihyfkip 361 ldsenneesa dqinmmdiad leepflprpn smvvslkacr qnietlltki pqifqsnlit 421 nfalgpalks ayhliggvgg kiivvsgtlp nlgigklqrr nesgvvntsk etaqllscqd 481 sfyknftidc skvqitvdlf lasedymdva slsnlsrfta gqthfypgfs gknpndivkf 541 stefakhism dfcmetvmra rgstglrmsr fyghffnrss dlcafstmpr dqsylfevnv 601 desimadycy vqvavllsln nsqrririit lampttesla evyasadqla iasfynskav 661 ekalnssldd arvlinksvq dilatykkei vvsntaggap lrlcanlrmf pllmhsltkh 721 mafrsgivps dhrasalnnl eslplkylik niypdvyslh dmadeaglpv qtedgeatgt 781 ivlpqpinat sslferygly lidngnelfl wmggdavpal vfdvfgtqdi fdipigkqei 841 pvvensefnq rvrniinqlr nhddvityqs lyivrgasls epvnhasare vatlrlwass 901 tlvedkilnn esyreflqim karisk // LOCUS NP_012158 696 aa linear PLN 30-JUN-2025 DEFINITION putative metalloendopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012158 VERSION NP_012158.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179456.1 REFERENCE 1 (residues 1 to 696) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 696) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 696) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 696) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 696) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 696) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 696) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08445. Method: conceptual translation. FEATURES Location/Qualifiers source 1..696 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..696 /product="putative metalloendopeptidase" /calculated_mol_wt="77283" Region 7..430 /region_name="Metallopep" /note="Putative peptidase family; pfam12044" /db_xref="CDD:432283" Region 533..694 /region_name="Jacalin_metallopeptidase_like" /note="Jacalin-like lectin domain of putative metalloproteases and similar proteins; cd09613" /db_xref="CDD:187709" Site order(537..538,555..557,559,615..616,637..639,641,661..662, 683..685,687) /site_type="other" /note="putative sugar binding site [chemical binding]" /db_xref="CDD:187709" CDS 1..696 /locus_tag="YIL108W" /coded_by="NM_001179456.1:1..2091" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /note="Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:854698" /db_xref="SGD:S000001370" ORIGIN 1 mvgskdidlf nlreneqivs pclivhgkcn kqngaktvqv qhpqlppity pihnqffkat 61 viltpgenkl tfvtdtntar tivcyytplt qnppvhlcli lakdsplqfd spreqkdreg 121 gnglelaikk lrlgarlmqa ytneqmlrns mgnrtfpfve eftwdtlfer pamrntikih 181 vvrsektvke iqdpdiaqqn skgkntgalf giamdalksy ggpftnnekp vqaacmfldt 241 hwdgklirgh aalgggddsi klaifgshgl yswptcleql vpyftdetrs stsevandcn 301 ecgtyweclt itlgafmhei ghllgcphqe sgvmlrgytt lnrsfltkea ysvrtnstga 361 sppifpkeec twnrldtvrf lyhpsftlpq dyydpsfmrp tklggypnik hsvyplgngs 421 crilsptgiy lieiicddla rghieylpvs lggqgpqrev ivtlddlrar lpknelakfg 481 ntfklkilsv napetefdkf pslldvqpld mskygfsknv qgiksplygr sdggnavgvv 541 afdvrlvtav riyhgyaldg vrfyykekpt gtkdapaskp svpprnyfsk ithsiknhas 601 ineenlksvl fghetqnftd atlepgeiii gfnlrcgawv daiqiitshg rmtdmfgnkd 661 gggfaelqpp ngqyilgvtg rvgqwvdafg iiygal // LOCUS NP_012159 827 aa linear PLN 30-JUN-2025 DEFINITION 6-phosphofructo-2-kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012159 VERSION NP_012159.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179455.1 REFERENCE 1 (residues 1 to 827) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 827) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 827) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 827) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08446. Method: conceptual translation. FEATURES Location/Qualifiers source 1..827 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..827 /product="6-phosphofructo-2-kinase" /EC_number="2.7.1.105" /calculated_mol_wt="93286" Region 171..396 /region_name="6PF2K" /note="6-phosphofructo-2-kinase; pfam01591" /db_xref="CDD:396253" Region 399..609 /region_name="His_Phos_1" /note="Histidine phosphatase superfamily (branch 1); pfam00300" /db_xref="CDD:459751" CDS 1..827 /gene="PFK26" /locus_tag="YIL107C" /coded_by="NM_001179455.1:1..2484" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:1657152]" /experiment="EXISTENCE:direct assay:GO:0003873 6-phosphofructo-2-kinase activity [PMID:1322693]" /experiment="EXISTENCE:mutant phenotype:GO:0003873 6-phosphofructo-2-kinase activity [PMID:1657152]" /experiment="EXISTENCE:mutant phenotype:GO:0006003 fructose 2,6-bisphosphate metabolic process [PMID:1657152]" /note="6-phosphofructo-2-kinase; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A" /db_xref="GeneID:854699" /db_xref="SGD:S000001369" ORIGIN 1 mfkpvdfset spvppdidla ptqsphhvap sqdssydlls rssddkidae kgphdelskh 61 lplfqkrpls dtpissnwns pgiteentps dspensatnl kslhrlhind etqlknakip 121 tndttdympp sdganevtri dlkdiksptr hhkrrpttid vpgltkskts pdgliskeds 181 gsklvivmvg lpatgksfit nklsrflnys lyyckvfnvg ntrrkfakeh glkdqdskff 241 epknadstrl rdkwamdtld elldyllegs gsvgifdatn tsrerrknvl arirkrsphl 301 kvlflesvcs dhalvqknir lklfgpdykg kdpesslkdf ksrlanylka yepieddenl 361 qyikmidvgk kviayniqgf lasqtvyyll nfnladrqiw itrsgesedn vsgriggnsh 421 ltprglrfak slpkfiarqr eifyqnlmqq kknnentdgn iyndffvwts mrartigtaq 481 yfneddypik qmkmldelsa gdydgmtype iknnfpeefe krqkdklryr ypgiggesym 541 dvinrlrpvi teleriednv liithrvvar allgyfmnls mgiianldvp lhcvyclepk 601 pygitwslwe ydeasdsfsk vpqtdlnttr vkevglvyne rrysviptap psarssfasd 661 flsrkrsnpt sasssqsels eqpknsvsaq tgsnnttlig snfnikneng dsriplsapl 721 matntsnnil dgggtsisih rprvvpnqnn vnpllannnk aasnvpnvkk saatprqife 781 idkvdeklsm lknksfllhg kdypnnadnn dnediraktm nrsqshv // LOCUS NP_012160 314 aa linear PLN 30-JUN-2025 DEFINITION Mob1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012160 VERSION NP_012160.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179454.1 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08447. On Jan 7, 2000 this sequence version replaced NP_012160.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..314 /product="Mob1p" /calculated_mol_wt="35751" Region 134..304 /region_name="Mob1_phocein" /note="Mob1/phocein family; pfam03637" /db_xref="CDD:461000" CDS 1..314 /gene="MOB1" /locus_tag="YIL106W" /coded_by="NM_001179454.1:1..945" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:11434459]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11434459|PMID:11564880]" /experiment="EXISTENCE:direct assay:GO:0019207 kinase regulator activity [PMID:11404483]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0034973 Sid2-Mob1 complex [PMID:9528782]" /experiment="EXISTENCE:direct assay:GO:0044732 mitotic spindle pole body [PMID:11564880]" /experiment="EXISTENCE:genetic interaction:GO:0007096 regulation of exit from mitosis [PMID:9436989]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:11564880]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:9436989]" /experiment="EXISTENCE:physical interaction:GO:0034973 Sid2-Mob1 complex [PMID:9528782]" /note="Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress" /db_xref="GeneID:854700" /db_xref="SGD:S000001368" ORIGIN 1 msflqnfhis pgqtirstrg fkwntanaan nagsvsptka tphnntingn nnnantinnr 61 adftnnpvng ynesdhgrms pvlttpkrha pppeqlqnvt dfnytpshqk pflqpqagtt 121 vtthqdikqi vemtlgsegv lnqavklprg edenewlavh cvdfynqinm lygsitefcs 181 pqtcprmiat neyeylwafq kgqppvsvsa pkyveclmrw cqdqfddesl fpskvtgtfp 241 egfiqrviqp ilrrlfrvya hiychhfnei lelnlqtvln tsfrhfclfa qefellrpad 301 fgpllelvme lrdr // LOCUS NP_012161 686 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol 4,5-bisphosphate-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012161 VERSION NP_012161.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179453.1 REFERENCE 1 (residues 1 to 686) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 686) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 686) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 686) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08448. Method: conceptual translation. FEATURES Location/Qualifiers source 1..686 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..686 /product="phosphatidylinositol 4,5-bisphosphate-binding protein" /calculated_mol_wt="77864" Region 261..441 /region_name="BAR_4" /note="BAR-like domain; pfam20400" /db_xref="CDD:466549" Region 467..581 /region_name="PH_Slm1" /note="Slm1 Pleckstrin homology (PH) domain; cd13311" /db_xref="CDD:270121" Site order(478,483..485,542,562) /site_type="other" /note="non-cannonical phosphoinositide binding site [chemical binding]" /db_xref="CDD:270121" CDS 1..686 /gene="SLM1" /locus_tag="YIL105C" /gene_synonym="LIT2" /coded_by="NM_001179453.1:1..2061" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:15689497|PMID:21119626]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15372071|PMID:16622836|PMID:17101780|PMID:15689497]" /experiment="EXISTENCE:direct assay:GO:0046625 sphingolipid binding [PMID:21119626]" /experiment="EXISTENCE:genetic interaction:GO:0001558 regulation of cell growth [PMID:15689497]" /experiment="EXISTENCE:genetic interaction:GO:0016197 endosomal transport [PMID:21451250]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:15689497|PMID:15372071]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:15689497]" /experiment="EXISTENCE:genetic interaction:GO:0070941 eisosome assembly [PMID:21451250]" /experiment="EXISTENCE:genetic interaction:GO:0072659 protein localization to plasma membrane [PMID:22307609]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:15689497]" /experiment="EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:15689497]" /experiment="EXISTENCE:physical interaction:GO:0031929 TOR signaling [PMID:15689497]" /note="Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; protein abundance increases in response to DNA replication stress; SLM1 has a paralog, SLM2, that arose from the whole genome duplication" /db_xref="GeneID:854701" /db_xref="SGD:S000001367" ORIGIN 1 msknntmtsa vsdmlsqqql nlqhlhnlqq htrsmtsadh anvlqqqqqq qqqqqqqqqq 61 qqqsasfqng sltsdinqqs ylngqpvpst snstfqnnrt ltmnsgglqg iisngspnid 121 sntnvtiavp dpnnnngkql qgknsltnts ilsrarsslq rqrlaqqqqq qqdprsplvi 181 lvptaaqptd ilaarfsawr nviksvivyl teiasiqdei vrqqlrlsha vqfpffsien 241 qyqpssqedk svqkfflplg ngsiqdlpti lnqyheslas saskasrelt ndviprledl 301 rrdlivkike ikslqsdfkn scskelqqtk qamkqfqesl kdarysvpkq dpfltklald 361 rqikkqlqee nflheafdnl etsgaeleki vvmeiqnslt iyarllgqea qlvfdilisk 421 ldsgffnvdp qfewdnfisr dpnfllpnlp mrtfkeivyk yqfdpltyei ksgflerrsk 481 flksyskgyy vltpnflhef ktadrkkdlv pvmslalsec tvtehsrkns tsspnstgsd 541 akfvlhakqn giirrghnwv fkadsyesmm swfdnlkilt stsniqdkyk fitqklnlns 601 dgkpkltnnh tsinkyqlsn anstmvende nddinsnyvg stvtpkldnq tntntsmssl 661 pdtndselqd qvpniyiqtp indfks // LOCUS NP_001257679 46 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL105W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257679 VERSION NP_001257679.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270750.1 REFERENCE 1 (residues 1 to 46) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 46) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 46) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 46) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35117. Method: conceptual translation. FEATURES Location/Qualifiers source 1..46 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..46 /product="uncharacterized protein" /calculated_mol_wt="5804" CDS 1..46 /locus_tag="YIL105W-A" /coded_by="NM_001270750.1:1..141" /note="hypothetical protein; completely overlaps the verified gene SLM1; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; mRNA identified as translated by ribosome profiling data" /db_xref="GeneID:13393613" /db_xref="SGD:S000028657" ORIGIN 1 mktwmysylf dcpilvlpwt phnyylyhrf hhflplcywh ysadty // LOCUS NP_012162 507 aa linear PLN 30-JUN-2025 DEFINITION Hsp90 cochaperone SHQ1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012162 VERSION NP_012162.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179452.3 REFERENCE 1 (residues 1 to 507) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 507) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 507) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 507) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08449. On Jul 30, 2012 this sequence version replaced NP_012162.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..507 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..507 /product="Hsp90 cochaperone SHQ1" /calculated_mol_wt="59020" Region 9..90 /region_name="p23_like" /note="Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including...; cd06463" /db_xref="CDD:107220" Region 268..470 /region_name="SHQ1" /note="SHQ1 protein; pfam04925" /db_xref="CDD:461483" CDS 1..507 /gene="SHQ1" /locus_tag="YIL104C" /coded_by="NM_001179452.3:1..1524" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:12228251]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:19426738]" /experiment="EXISTENCE:mutant phenotype:GO:0000493 box H/ACA snoRNP assembly [PMID:12228251]" /experiment="EXISTENCE:physical interaction:GO:0000493 box H/ACA snoRNP assembly [PMID:12228251]" /note="Chaperone protein; required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing; functions as an RNA mimic; forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:854702" /db_xref="SGD:S000001366" ORIGIN 1 mitprfsitq deefiflkif isnirfsavg leiiiqenmi ifhlspyylr lrfphelidd 61 erstaqydsk decinvkvak lnkneyfedl dlptkllarq gdlagadalt entdakktqk 121 pliqevetdg vsnnikddvk tigqmgegfn weieqkmdss tnngilktky gfdnlydtvi 181 svstsngndi nelddpehtd andrvierlr kenlkfdpey yvseymthky gneedleing 241 ikellkftps ivkqylqwyk dstnpnlvmp ieftdeeqkq mqdnlpkksy lvedikplyv 301 tilsvlfsyv feqienegth ttesawtmgk lcpqisfldq qlkqvnelqd gmkeiskvnk 361 dsslikiaii tgirralsyp lhrnydlamk awtfvyyilr ggkrlviral ldihetfrfh 421 dvyyvydkvl lddltawfis qgsenvirsl alemrkeqes lskqdiefec iasfneqtge 481 pewetlnire meilaeseyr eqqqnpq // LOCUS NP_012163 425 aa linear PLN 30-JUN-2025 DEFINITION 2-(3-amino-3-carboxypropyl)histidine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012163 VERSION NP_012163.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179451.1 REFERENCE 1 (residues 1 to 425) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 425) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 425) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 425) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08450. Method: conceptual translation. FEATURES Location/Qualifiers source 1..425 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..425 /product="2-(3-amino-3-carboxypropyl)histidine synthase" /EC_number="2.5.1.108" /calculated_mol_wt="48180" Region 99..403 /region_name="Diphthamide_syn" /note="Putative diphthamide synthesis protein; pfam01866" /db_xref="CDD:460365" CDS 1..425 /gene="DPH1" /locus_tag="YIL103W" /coded_by="NM_001179451.1:1..1278" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0017183 protein histidyl modification to diphthamide [PMID:15485916]" /note="Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph2p that catalyzes the first step of diphthamide biosynthesis" /db_xref="GeneID:854703" /db_xref="SGD:S000001365" ORIGIN 1 msgsteskkq prrrfigrks gnsnndkltt vaengneiih kqksrialgr svnhvpedil 61 ndkelneaik llpsnynfei hktvwnirky nakrialqmp eglliyslii sdileqfcgv 121 etlvmgdvsy gacciddfta raldcdfivh yahsclvpid vtkikvlyvf vtiniqedhi 181 iktlqknfpk gsriatfgti qfnpavhsvr dkllndeehm lyiippqikp lsrgevlgct 241 serldkeqyd amvfigdgrf hlesamihnp eipafkydpy nrkftregyd qkqlvevrae 301 aievarkgkv fglilgalgr qgnlntvknl eknliaagkt vvkiilsevf pqklamfdqi 361 dvfvqvacpr lsidwgyafn kplltpyeas vllkkdvmfs ekyypmdyye akgygrgetp 421 khaie // LOCUS NP_001032579 75 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL102C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032579 VERSION NP_001032579.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184686.1 REFERENCE 1 (residues 1 to 75) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 75) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 75) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 75) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08451. Method: conceptual translation. FEATURES Location/Qualifiers source 1..75 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..75 /product="uncharacterized protein" /calculated_mol_wt="8371" CDS 1..75 /locus_tag="YIL102C-A" /coded_by="NM_001184686.1:1..228" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Regulatory subunit of dolichyl phosphate mannose (DPM) synthase; identified based on comparisons of the genome sequences of six Saccharomyces species; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the endoplasmic reticulum" /db_xref="GeneID:3799974" /db_xref="SGD:S000113587" ORIGIN 1 mnrfviicll ftyyviwsll pifeiensnp vvsllfpiss nvaiflpifl lligftltgs 61 vlgvllirsd kkkkv // LOCUS NP_012164 101 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL102C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012164 VERSION NP_012164.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179450.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08452. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..101 /product="uncharacterized protein" /calculated_mol_wt="11159" CDS 1..101 /locus_tag="YIL102C" /coded_by="NM_001179450.1:1..306" /note="hypothetical protein" /db_xref="GeneID:854704" /db_xref="SGD:S000001364" ORIGIN 1 mlkvekfkkl krfevyyclk nsfleevdie mkyscsitti msngsasllm nweeltpghc 61 ftsyttnpia gdyglnasai dghteelvat hpagtlenat q // LOCUS NP_012165 647 aa linear PLN 30-JUN-2025 DEFINITION Xbp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012165 VERSION NP_012165.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179449.1 REFERENCE 1 (residues 1 to 647) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 647) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 647) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 647) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08453. Method: conceptual translation. FEATURES Location/Qualifiers source 1..647 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..647 /product="Xbp1p" /calculated_mol_wt="72557" CDS 1..647 /gene="XBP1" /locus_tag="YIL101C" /coded_by="NM_001179449.1:1..1944" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:10611226]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:9343412]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:9343412]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11340165|PMID:10611226|PMID:24204289|PMID:9343412]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:11340165]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:10611226]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:9343412]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:10611226]" /experiment="EXISTENCE:mutant phenotype:GO:0070314 G1 to G0 transition [PMID:24204289]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:9343412]" /note="Transcriptional repressor; binds promoter sequences of cyclin genes, CYS3, and SMF2; not expressed during log phase of growth, but induced by stress or starvation during mitosis, and late in meiosis; represses 15% of all yeast genes as cells transition to quiescence; important for maintaining G1 arrest and for longevity of quiescent cells; member of Swi4p/Mbp1p family; phosphorylated by Cdc28p; relative distribution to nucleus increases upon DNA replication stress" /db_xref="GeneID:854706" /db_xref="SGD:S000001363" ORIGIN 1 mkypafsins dtvhltdnpl ddyqrlylvs vldrdsppas fsaglnirkv nykssiaaqf 61 thpnfiisar dagngeeaaa qnvlncfeyq fpnlqtiqsl vheqtllsql assatphsal 121 hlhdknilmg kiilpsrsnk tpvsasptkq ekkalstasr enatssltkn qqfkltkmdh 181 nlindklinp nncviwshds gyvfmtgiwr lyqdvmkgli nlprgdsvst sqqqffckae 241 fekilsfcfy nhssftsees ssvllsssts sppkrrtstg stfldanass sstsstqann 301 yidfhwnnik pelrdlicqs ykdflinelg pdqidlpnln panftkrirg gyikiqgtwl 361 pmeisrllcl rfcfpiryfl vpifgpdfpk dceswylahq nvtfassttg agaataataa 421 antstnftst avarprqkpr prprqrstsm shskaqklvi edalpsfdsf venlglssnd 481 knfikknskr qksstytsqt sspigprdpt vqilsnlasf ynthghrysy pgniyipqqr 541 yslpppnqls spqrqlnyty dhihpvpsqy qsprhynvps spiapapptf pqpygddhyh 601 flkyasevyk qqnqrpahnt ntnmdtsfsp rannslnnfk fktnskq // LOCUS NP_012167 549 aa linear PLN 30-JUN-2025 DEFINITION glucan 1,4-alpha-glucosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012167 VERSION NP_012167.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179447.3 REFERENCE 1 (residues 1 to 549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 549) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08454. On Jul 30, 2012 this sequence version replaced NP_012167.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..549 /product="glucan 1,4-alpha-glucosidase" /EC_number="3.2.1.3" /calculated_mol_wt="61332" Region 91..535 /region_name="Glyco_hydro_15" /note="Glycosyl hydrolases family 15; pfam00723" /db_xref="CDD:395586" CDS 1..549 /gene="SGA1" /locus_tag="YIL099W" /coded_by="NM_001179447.3:1..1650" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:2493265|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004339 glucan 1,4-alpha-glucosidase activity [PMID:2493265]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0005980 glycogen catabolic process [PMID:11486014]" /note="Intracellular sporulation-specific glucoamylase; involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation" /db_xref="GeneID:854708" /db_xref="SGD:S000001361" ORIGIN 1 marqkmfynk llgmlsvgfg fawaleniti yefdfgkgil dqsyggvfsn ngpsqvqlrd 61 avlmngtvvy dsngawdssa leewlqgqkk vsiekifeni gpsavypsis pgvviaspsq 121 thpdyfyqwi rdsaltinsi vshsagpaie tllqylnvsf hlqrsnntlg agigytndtv 181 algdpkwnvd ntaftedwgr pqndgpalrs iailkiidyi kqsgtdlgak ypfqstadif 241 ddivrwdlrf iidhwnssgf dlweevngmh fftllvqlsa vdkslsyfna sersspfvee 301 lrqtrrdisk flvdpangfi ngkynyivgt pmiadtlrsg ldistllaan tvhdapsash 361 lpfdindpav lntlhhlmlh mrsiypinds sknatgialg rypedvydgy gfgegnpwvl 421 atctasttly qliyrhiseq hdlvvpmnnd csnafwselv fsnlttlgnd egylilefnt 481 pafnqtiqki fqladsflvk lkahvgtdge lseqfnkytg fmqgaqhltw sytsfwdayq 541 irqevlqsl // LOCUS NP_012168 155 aa linear PLN 30-JUN-2025 DEFINITION Fmc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012168 VERSION NP_012168.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179446.3 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08455. On Jul 30, 2012 this sequence version replaced NP_012168.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..155 /product="Fmc1p" /calculated_mol_wt="18233" Region <108..152 /region_name="Complex1_LYR_2" /note="Complex1_LYR-like; pfam13233" /db_xref="CDD:463812" CDS 1..155 /gene="FMC1" /locus_tag="YIL098C" /coded_by="NM_001179446.3:1..468" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11096112]" /experiment="EXISTENCE:genetic interaction:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:11096112]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:11096112]" /note="Mitochondrial matrix protein; required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p" /db_xref="GeneID:854709" /db_xref="SGD:S000001360" ORIGIN 1 mdrprtlrty rglirailky erpskivnwg nlrkamitkl eyakkqnqrd sheninrqle 61 kwkkldpvsd rslnlfiads kslrsilqnd ikwekkvaqg qnvdeifeha ldiikfldnq 121 reyeelvdry npgnkltqde kvkrtanvvg ldvpt // LOCUS NP_012169 516 aa linear PLN 30-JUN-2025 DEFINITION glucose-induced degradation complex subunit FYV10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012169 VERSION NP_012169.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179445.1 REFERENCE 1 (residues 1 to 516) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 516) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 516) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 516) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08456. Method: conceptual translation. FEATURES Location/Qualifiers source 1..516 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..516 /product="glucose-induced degradation complex subunit FYV10" /EC_number="2.3.2.27" /calculated_mol_wt="59763" Region 187..392 /region_name="CTLH" /note="CTLH/CRA C-terminal to LisH motif domain; pfam10607" /db_xref="CDD:402305" CDS 1..516 /gene="FYV10" /locus_tag="YIL097W" /gene_synonym="GID9" /coded_by="NM_001179445.1:1..1551" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0034657 GID complex [PMID:18508925|PMID:16872538]" /experiment="EXISTENCE:mutant phenotype:GO:0043066 negative regulation of apoptotic process [PMID:18355271]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:22044534]" /note="Subunit of GID complex; involved in proteasome-dependent catabolite inactivation of gluconeogenic enzymes FBPase, PEPCK, and c-MDH; forms dimer with Rmd5p that is then recruited to GID Complex by Gid8p; contains a degenerate RING finger motif needed for GID complex ubiquitin ligase activity in vivo, as well as CTLH and CRA domains; plays role in anti-apoptosis; required for survival upon exposure to K1 killer toxin" /db_xref="GeneID:854710" /db_xref="SGD:S000001359" ORIGIN 1 maeksifnep dvdfhlklnq qlfhipyell skrikhtqav inketkslhe htaalnqife 61 hndvehdela lakitemirk vdhierflnt qiksycqiln rikkrleffh elkdiksqns 121 gtshngnneg trtkliqwyq sytniligdy ltrnnpikyn setkdhwnsg vvflkqsqld 181 dlidydvlle anristsllh ernllplisw inenkktltk kssilefqar lqeyiellkv 241 dnytdaivcf qrfllpfvks nftdlklasg llifikycnd qkptsstssg fdteeiksqs 301 lpmkkdrifq hffhkslpri tskpavnttd ydksslinlq sgdferylnl lddqrwsvln 361 dlflsdfysm ygisqndpll iylslgissl ktrdclhpsd dengnqetet attaekeved 421 lqlftlhslk rkncpvcset fkpitqalpf ahhiqsqlfe npillpngnv ydskklkkla 481 ktlkkqnlis lnpgqimdpv dmkifcesds ikmypt // LOCUS NP_012170 336 aa linear PLN 30-JUN-2025 DEFINITION 25S rRNA (uracil2634-N3)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012170 VERSION NP_012170.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179444.1 REFERENCE 1 (residues 1 to 336) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 336) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 336) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 336) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08457. Method: conceptual translation. FEATURES Location/Qualifiers source 1..336 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..336 /product="25S rRNA (uracil2634-N3)-methyltransferase" /EC_number="2.1.1.313" /calculated_mol_wt="39271" Region 76..292 /region_name="BMT5-like" /note="rRNA (uridine-N3-)-methyltransferase BTM5-like; pfam10354" /db_xref="CDD:463056" CDS 1..336 /gene="BMT5" /locus_tag="YIL096C" /coded_by="NM_001179444.1:1..1011" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:24335083|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:21858014]" /experiment="EXISTENCE:mutant phenotype:GO:0070042 rRNA (uridine-N3-)-methyltransferase activity [PMID:24335083]" /experiment="EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:24335083]" /note="Methyltransferase required for m3U2634 methylation of the 25S rRNA; S-adenosylmethionine-dependent; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis" /db_xref="GeneID:854711" /db_xref="SGD:S000001358" ORIGIN 1 marklkgkig skglkgallr hkakvklvrn ieskqkhelr kknssannkt vkrnqefqkl 61 nqgkvmpfek detlmlcgeg dfsfarsive qnyiesdnli itsydnsvne lklkyphtfe 121 enyqylkdln ipiffqidvt klvksfkisk nntwfkiinr lsdhrwgnkp lqnivfnfph 181 ngkgikdqer nirehqdlif nffqnslqlf nlintkiqnd tlrytqgydl nedtpqakkl 241 taegygniil slfdgepyds wqikllakkn gltlsrsskf qwenfpgyhh rrtnseqdtt 301 kpakerdarf yifskyvsns skhnrkskkd tdsdsd // LOCUS NP_012171 810 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase PRK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012171 VERSION NP_012171.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179443.1 REFERENCE 1 (residues 1 to 810) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 810) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 810) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 810) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08458. Method: conceptual translation. FEATURES Location/Qualifiers source 1..810 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..810 /product="serine/threonine protein kinase PRK1" /EC_number="2.7.11.1" /calculated_mol_wt="90901" Region 18..300 /region_name="STKc_NAK_like" /note="Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; cd14037" /db_xref="CDD:270939" Site order(28..32,36,54,56,86,108..111,115,117,158,160,162..163, 165,176,179,204..207) /site_type="active" /db_xref="CDD:270939" Site order(28..32,36,54,56,86,108..111,115,158,160,162..163,165, 176) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270939" Site order(32,115,117,158,160,162,179,204..207) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270939" Site order(175..189,191..207) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270939" CDS 1..810 /gene="PRK1" /locus_tag="YIL095W" /gene_synonym="PAK1" /coded_by="NM_001179443.1:1..2433" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:13679512|PMID:11739778|PMID:12956961|PMID:9885245|PM ID:17978096]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10087264|PMID:9885245]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0120133 negative regulation of actin cortical patch assembly [PMID:9885245]" /experiment="EXISTENCE:genetic interaction:GO:1900186 negative regulation of clathrin-dependent endocytosis [PMID:13679512]" /experiment="EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:12952930]" /experiment="EXISTENCE:mutant phenotype:GO:0031333 negative regulation of protein-containing complex assembly [PMID:11739778]" /experiment="EXISTENCE:mutant phenotype:GO:1900186 negative regulation of clathrin-dependent endocytosis [PMID:12956961]" /note="Ser/Thr protein kinase; regulates the organization and function of the actin cytoskeleton; inhibits clathrin-mediated endocytosis; phosphorylates the Pan1p and Sla1p subunits of the Pan1p-Sla1p-End3p complex, resulting in inhibition of complex formation; inhibits Scd5p through phosphorylation; phosphorylates Pan1p-interacting proteins, Ent1/2 and Yap1801/2; negatively regulated through autophosphorylation; functional overlap with ARK1" /db_xref="GeneID:854713" /db_xref="SGD:S000001357" ORIGIN 1 mntpqislye pgtiltvgsh hakiikylts ggfaqvytae isppdpysna niaclkrviv 61 phkqglntlr aevdamkllr nnkhvvsyid shaarsvngi ayevfvlmef cergglidfm 121 ntrlqnrlqe seileimsqt vqgitamhal qpplihrdik ienvlishdg lykvcdfgsv 181 sgvirpprnt qefnyvqhdi ltnttaqyrs pemidlyrgl pideksdiwa lgvflykicy 241 yttpfeksge agilharyqy psfpqysdrl knlirlmlme apsqrpnicq vleevsrlqn 301 kpcpirnfyl lramnqnant qlagepsstt yvptqkfipv qslqsinqpp nmmpvthvst 361 tpnlgtfpis indnnktevt ahaglqvgsh snltsplmkt ksvplsdefa slyykelhpf 421 qksqtfksve sfqspqrksm pplsltpvnn difdrvsain rpnnyvdset qtidnmavpn 481 lklsptitsk slsstkeiaa pdningskiv rslssklkkv itgesrgnsp iksrqntgds 541 irsafgklrh gftgnsvnns rsasfdnnnv ngngnntnrr lvssstssfp kfnsdtkrke 601 esdknqrlek rrsmppsils dfdqhernns rtgsrdyyrs hspvkktqas akttskptli 661 pdngnvninq ekkesiqrrv hnllkssddp vtyksasgyg kytdigtets nrhssvritp 721 iteekfkktl kdgvldiktk sngkdksrpp rpppkplhlr teiqkirnfs rlqskklpie 781 risseateti vdvnvddlea dfrkrfpskv // LOCUS NP_012172 371 aa linear PLN 30-JUN-2025 DEFINITION homoisocitrate dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012172 VERSION NP_012172.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179442.1 REFERENCE 1 (residues 1 to 371) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 371) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 371) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 371) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08459. Method: conceptual translation. FEATURES Location/Qualifiers source 1..371 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..371 /product="homoisocitrate dehydrogenase" /EC_number="1.1.1.87" /calculated_mol_wt="39938" Region 23..371 /region_name="LeuB" /note="Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; COG0473" /db_xref="CDD:440241" CDS 1..371 /gene="LYS12" /locus_tag="YIL094C" /gene_synonym="LYS10; LYS11" /coded_by="NM_001179442.1:1..1116" /experiment="EXISTENCE:curator inference:GO:0009085 lysine biosynthetic process [PMID:17223711]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:11914276|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0047046 homoisocitrate dehydrogenase activity [PMID:17223711]" /note="Homo-isocitrate dehydrogenase; an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate" /db_xref="GeneID:854714" /db_xref="SGD:S000001356" ORIGIN 1 mfrsvatrls acrglasnaa rksltiglip gdgigkevip agkqvlenln skhglsfnfi 61 dlyagfqtfq etgkalpdet vkvlkeqcqg alfgavqspt tkvegysspi valrremglf 121 anvrpvksve gekgkpidmv ivrentedly ikiektyidk atgtrvadat kriseiatrr 181 iatialdial krlqtrgqat ltvthksnvl sqsdglfrei ckevyesnkd kygqikyneq 241 ivdsmvyrlf repqcfdviv apnlygdils dgaaalvgsl gvvpsanvgp eivigepchg 301 sapdiagkgi anpiatirst almleflghn eaaqdiykav danlregsik tpdlggkast 361 qqvvddvlsr l // LOCUS NP_012173 264 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS23 RSM25 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012173 VERSION NP_012173.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179441.3 REFERENCE 1 (residues 1 to 264) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 264) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 264) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 264) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08460. On Jul 30, 2012 this sequence version replaced NP_012173.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..264 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..264 /product="mitochondrial 37S ribosomal protein mS23 RSM25" /calculated_mol_wt="30382" Region 7..230 /region_name="MRP-S25" /note="Mitochondrial ribosomal protein S25; pfam13741" /db_xref="CDD:433447" CDS 1..264 /gene="RSM25" /locus_tag="YIL093C" /gene_synonym="mS23" /coded_by="NM_001179441.3:1..795" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:854715" /db_xref="SGD:S000001355" ORIGIN 1 mkiqtnavnv lqrtsaylks gllketpawy nvvasippst kftreprfkn psnghiigkl 61 vdvteqphan nkglyktrpn ssdkrvgvkr lyrppkltyv edrlrslfyk qhpwelsrpk 121 ilveneigde nydwshmlqi grpldgesvi qrtmyliktk qygdmveayd haryefyalr 181 mqeeteqqva leeaemfgsl fgvsaiehgi qkeqevldvw ekkvveetel maartsnpag 241 swkddttlnt aqeeesttse nlhf // LOCUS NP_012174 633 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL092W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012174 VERSION NP_012174.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179440.3 REFERENCE 1 (residues 1 to 633) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 633) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 633) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 633) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08461. On Jul 30, 2012 this sequence version replaced NP_012174.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..633 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..633 /product="uncharacterized protein" /calculated_mol_wt="70875" CDS 1..633 /locus_tag="YIL092W" /coded_by="NM_001179440.3:1..1902" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus" /db_xref="GeneID:854716" /db_xref="SGD:S000001354" ORIGIN 1 mvqmrsknma yesgtnnysd tiangntlpp rskkghsgrr krsetlpiac nnfcvtrqid 61 ddeqafkmld kvshlkkfsa edgddnnifv qwadditdil fglcctgtfl kllissalsg 121 raktwfdstt egiddhvika ysfekflall seefdgarsl rreiftellt lsidseksle 181 afahksgrlt pyylssgaal dlfltklepq lqkqlencaf pmtlnlalli tacefakras 241 nhkkyryknt rdsdictpks kntaivskls ntktisknkv ieksdkknyf dknsqhipdp 301 krrkqnepgm rlflvmdeek niltsrnvsa naytsknght nlsdlhtnlk nsksqqcave 361 pisilnsgsl vtgtinidli ndevlgtkee tttydermdg nsrslnercc avkknslqpi 421 tsnifqknae iqgtkigsvl dsgisnsfss teymfpptss atvsnpvkkn eiskssqvkd 481 iaqfnpfmtn ekekklnpse sfkspgvsme inrlsriagl rnipgniyed skmlnlktrk 541 cyplhnfavr trsahfndrp snyispheti natlrspasf dsiqcitrsk rvdaetnkat 601 gsakseniet ksrkfpevin pflvnttnkk esd // LOCUS NP_012175 721 aa linear PLN 30-JUN-2025 DEFINITION rRNA-binding ribosome biosynthesis protein UTP25 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012175 VERSION NP_012175.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179439.1 REFERENCE 1 (residues 1 to 721) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 721) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 721) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 721) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 721) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 721) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 721) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08462. Method: conceptual translation. FEATURES Location/Qualifiers source 1..721 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..721 /product="rRNA-binding ribosome biosynthesis protein UTP25" /calculated_mol_wt="83860" Region 248..720 /region_name="UTP25" /note="Utp25, U3 small nucleolar RNA-associated SSU processome protein 25; pfam06862" /db_xref="CDD:369113" CDS 1..721 /gene="UTP25" /locus_tag="YIL091C" /coded_by="NM_001179439.1:1..2166" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:20528918|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:14690591|PMID:20528918]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:20528918]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:20884785]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:20528918]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:20884785|PMID:20528918]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:19806183|PMID:20884785|PMID:20528918]" /experiment="EXISTENCE:physical interaction:GO:0032040 small-subunit processome [PMID:20528918]" /note="Nucleolar protein; required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis" /db_xref="GeneID:854717" /db_xref="SGD:S000001353" ORIGIN 1 msdssvrekn dnfrgyrkrg rqelrkikrs sarteggste tledvaedid hrsdedevsd 61 vdsgddfdie deegkkekvy dalltilkse hpepkrrrre adesnkapae vgedehente 121 hgpvddqlei engllgnhed dndddssgde kdidsedeqd pfeshfnqvp ekfvdklsna 181 fktksvkyks vkgslsdses yiyakpvvig eealvespyr sssiysyflk qrlkvqngll 241 dkktdpltal qkklvdpmfq ykdilyeyds yekdedeyrd lyalhvlnhi yktrdrilkn 301 nqrlqdnpdt ehldqgftrp kvlivvptre vayrvvdkii sksgidqvdk kgkfydqfrd 361 dslppkskpk sfqhifrgnt ndffvvglkf trkaiklysn fyqsdiivcs plgiqmilen 421 tdkkkrqddf lssielmvid qlhsieyqni shiftifdhl nkipdqqhea dfsrirmwyi 481 neqaklfrqt mvftkyispa anslingrcr nmagrwknhk vigsenssig qsglkirqif 541 qrfdiignsi ieepdyrfkf ftsviipgiv kstgyedgil iyipdytdfi rirnymkekt 601 tilfgdiney ssqrqlnanr slfqqgrlkv mlyterlhhy rryeikgvks vvfykppnnp 661 efynevvrfi gknaflgntd lnistvrciy skldglsler ivgtkraavl shaqkeiyef 721 k // LOCUS NP_012176 491 aa linear PLN 30-JUN-2025 DEFINITION Ice2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012176 VERSION NP_012176.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179438.1 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08463. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..491 /product="Ice2p" /calculated_mol_wt="56202" Region 14..488 /region_name="ICE2" /note="pfam08426" /db_xref="CDD:429989" CDS 1..491 /gene="ICE2" /locus_tag="YIL090W" /coded_by="NM_001179438.1:1..1476" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:15585575]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:15585575]" /experiment="EXISTENCE:direct assay:GO:0097038 perinuclear endoplasmic reticulum [PMID:15585575]" /experiment="EXISTENCE:genetic interaction:GO:0000921 septin ring assembly [PMID:17984322]" /experiment="EXISTENCE:genetic interaction:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:34617598]" /experiment="EXISTENCE:genetic interaction:GO:0160031 endoplasmic reticulum membrane biogenesis [PMID:34617598]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:17984322]" /experiment="EXISTENCE:mutant phenotype:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:34617598]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:22685415]" /experiment="EXISTENCE:mutant phenotype:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:32513868]" /experiment="EXISTENCE:mutant phenotype:GO:0036228 protein localization to nuclear inner membrane [PMID:15911569]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:15585575|PMID:17984322]" /experiment="EXISTENCE:mutant phenotype:GO:0160031 endoplasmic reticulum membrane biogenesis [PMID:34617598]" /note="Integral ER membrane protein with type-III transmembrane domains; promotes ER membrane expansion by inhibiting the Nem1-Spo7 phosphatase complex, resulting in reduced dephosphorylation and activation of Pah1p; maintains homeostasis during ER stress; required for post-translational SRP-independent protein translocation into the ER; necessary for efficient targeting of the Trm1p to the inner nuclear membrane; mutations cause defects in cortical ER morphology; member of the SERINC superfamily" /db_xref="GeneID:854718" /db_xref="SGD:S000001352" ORIGIN 1 mtslsksfmq sgricaacfy llftllsipi sfkvgglecg lsftvtlftl yfitttlnvl 61 arrhggrlyi fftnclyysq hfiiasllyl flsgfsndel gnvlknkyne sesflealkn 121 slnsnqinyv lyyyyyrfvv qpwqfvltks tpfftlsegf ftilaiqavg etnrwlsndl 181 nsntwiissl ltsggvitas lyylyriyvt piwplsiqta sllglvlsmv cglglygivs 241 qkgsviessl ffayivrciy eispklatta tdeilnlfkd vwqkhqrnlp tadnllcyfh 301 nvilknaevl wgsfiprgrk ktgdfhdkli silsfekvsl iskpfwkffk nftfsvplsi 361 nefcqvtikm asesvspaiv inlcfrvlmf ysatriipal qrkndkqlrk srrimkglyw 421 yspciliamy thlilqysge lkkdlciwgc sekwfgvdqp eiivdswgfw nwcnifctil 481 vyateligsg s // LOCUS NP_012177 205 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL089W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012177 VERSION NP_012177.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179437.1 REFERENCE 1 (residues 1 to 205) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 205) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 205) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 205) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08464. Method: conceptual translation. FEATURES Location/Qualifiers source 1..205 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..205 /product="uncharacterized protein" /calculated_mol_wt="23728" Region 29..190 /region_name="DUF4668" /note="Domain of unknown function (DUF4668); pfam15701" /db_xref="CDD:406192" CDS 1..205 /locus_tag="YIL089W" /coded_by="NM_001179437.1:1..618" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:21777356]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:21777356]" /note="hypothetical protein found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking" /db_xref="GeneID:854719" /db_xref="SGD:S000001351" ORIGIN 1 mqrtreless vaidqtevpr srffimvkkl srvadivyiv dtflipplhp lkkqhpkvak 61 flkvqlvfdl islfifathq lllledgnfg khyfkrktkr cskfscsrcn anahhpkwfk 121 fkhsllclgt fcfgvyslvk inkffktdqt vdlnrllelf fwqlnailnm klfafygdhl 181 eshsapldvy edsfanksss ggdev // LOCUS NP_012178 490 aa linear PLN 30-JUN-2025 DEFINITION Avt7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012178 VERSION NP_012178.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179436.1 REFERENCE 1 (residues 1 to 490) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 490) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 490) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 490) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08465. Method: conceptual translation. FEATURES Location/Qualifiers source 1..490 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..490 /product="Avt7p" /calculated_mol_wt="53606" Region 4..477 /region_name="Aa_trans" /note="Transmembrane amino acid transporter protein; pfam01490" /db_xref="CDD:279788" CDS 1..490 /gene="AVT7" /locus_tag="YIL088C" /coded_by="NM_001179436.1:1..1473" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11274162|PMID:26928762|PMID:27246536]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:25266154]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0006865 amino acid transport [PMID:25266154]" /experiment="EXISTENCE:mutant phenotype:GO:0043937 regulation of sporulation [PMID:25266154]" /note="Vacuolar amino acid transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" /db_xref="GeneID:854721" /db_xref="SGD:S000001350" ORIGIN 1 meatssalss tanlvktivg agtlaipysf ksdgvlvgvi ltllaavtsg lglfvlskcs 61 ktlinprnss fftlcmltyp tlapifdlam ivqcfgvgls ylvligdlfp glfggernyw 121 iiasaviiip lclvkkldql kyssilglfa layisilvfs hfvfelgkge ltnilrndic 181 wwkihdfkgl lstfsiiifa ftgsmnlfpm inelkdnsme nitfvinnsi slstalfliv 241 glsgyltfgn etlgnlmlny dpnsiwivig kfclgsmlil sfpllfhplr iavnnviiwi 301 eitygganpe edpqvseytr asnlrpismt vedpaqpsda ldatsyneqe cllpngnfdn 361 gsiesqennn dergtmavag dnehhapfvk srfywitall lismytlals vqsfalvlsf 421 vgatgstsis ftlpgllgyk ligldslaig kmippkdrfy krcslllvfy glsvmflsly 481 vtvfnrsdea // LOCUS NP_012179 157 aa linear PLN 30-JUN-2025 DEFINITION Aim19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012179 VERSION NP_012179.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179435.3 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08466. On Jul 30, 2012 this sequence version replaced NP_012179.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..157 /product="Aim19p" /calculated_mol_wt="16793" Region 42..152 /region_name="Aim19" /note="Altered inheritance of mitochondria protein 19; pfam10315" /db_xref="CDD:402092" CDS 1..157 /gene="AIM19" /locus_tag="YIL087C" /coded_by="NM_001179435.3:1..474" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:25124039]" /note="hypothetical protein; mitochondrial protein that physically interacts with Tim23p; null mutant displays reduced respiratory growth" /db_xref="GeneID:854722" /db_xref="SGD:S000001349" ORIGIN 1 msakpatdda kdellspfrr lyaltrtpyp alanaallas tpvlspsfkv pptqspalsi 61 pmsrvfskss tarigittkt alffstmqai gaymiydndl engagfiatw salylivggk 121 ksfsalrygr twplvlssvs lanavlygqr flatgfq // LOCUS NP_001335784 102 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL086C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335784 VERSION NP_001335784.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348844.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80304. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..102 /product="uncharacterized protein" /calculated_mol_wt="11453" CDS 1..102 /locus_tag="YIL086C" /coded_by="NM_001348844.1:1..309" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:854723" /db_xref="SGD:S000001348" ORIGIN 1 mnkiikestn fsrylrtggv lnslrttskf vyinnnsylt hggfdgnvat ifnisefnyi 61 nssakgsllt yksitffcpr yfkkrplgrh akgkgksdek il // LOCUS NP_012181 517 aa linear PLN 30-JUN-2025 DEFINITION putative mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012181 VERSION NP_012181.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179433.3 REFERENCE 1 (residues 1 to 517) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 517) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 517) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 517) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08467. On Jul 30, 2012 this sequence version replaced NP_012181.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..517 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..517 /product="putative mannosyltransferase" /calculated_mol_wt="61307" Region 7..490 /region_name="KTR1" /note="Mannosyltransferase [Carbohydrate transport and metabolism]; COG5020" /db_xref="CDD:227353" CDS 1..517 /gene="KTR7" /locus_tag="YIL085C" /coded_by="NM_001179433.3:1..1554" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:9090056]" /note="Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication" /db_xref="GeneID:854724" /db_xref="SGD:S000001347" ORIGIN 1 mairlnpkvr rflldkcrqk rygflflgci failycmgtw pffakdivhd pnnlpyslqd 61 ystdkdepff rgctdtklyl qnpayskmna sfvmltrnee iedvlktmrs ieghfnkwfk 121 ypyvflnddp ftdhfkdqiq aatnatvefg tvdeimwefp akvrnslqfk asledqndrg 181 imygnmesyh kmcrfysgif ykhplvskye wywriepdvd ffcdisydpf femakhnkky 241 gftvlitely wtvpnlfrtt ksfikktagl kenlgtlwkl ftfnynildt ddeeisrwvn 301 fpwdakpklt eklmvdflle nhgqvnneed legiqylver arskvpmled slegedynlc 361 hfwsnfeiar vdlfdneiyn ayfkfleesg gfwterwgda pihsiglgmt ldledvhyfr 421 digyrhsslq hcpknalqsq enlntfdegy nfgcgcrcvc pkkgediedh stpcmdiffe 481 llhgreyeke fpgcykpsik dkdvieeirr enfrvie // LOCUS NP_012182 327 aa linear PLN 30-JUN-2025 DEFINITION Sds3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012182 VERSION NP_012182.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179432.1 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08468. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..327 /product="Sds3p" /calculated_mol_wt="37494" Region 21..310 /region_name="Sds3" /note="Sds3-like; pfam08598" /db_xref="CDD:430099" CDS 1..327 /gene="SDS3" /locus_tag="YIL084C" /coded_by="NM_001179432.1:1..984" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16314178|PMID:19040720|PMID:16286007|PMID:16286008]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:24358376]" /experiment="EXISTENCE:mutant phenotype:GO:0004407 histone deacetylase activity [PMID:11024051]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:11024051]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0043709 cell adhesion involved in single-species biofilm formation [PMID:18202364]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17210643|PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:2000217 regulation of invasive growth in response to glucose limitation [PMID:18202364]" /note="Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes" /db_xref="GeneID:854725" /db_xref="SGD:S000001346" ORIGIN 1 maiqkvsnkd lsrkdkrrfn ieskvnkiyq nfyserdnqy kdrltalqtd ltslhqgdng 61 qyarqvrdle eerdlelvrl rlfeeyrvsr sgiefqedie kakaehekli klckerlyss 121 ieqkikklqe erllmdvanv hsyamnysrp qyqkntrsht vsgwdsssne ygrdtanesa 181 tdtgagndrr tlrrrnaskd trgnnnnqde sdfqtgngsg snghgsrqgs qfphfnnlty 241 ksgmnsdsdf lqginegtdl yaflfgeknp kdnangnekk knrgaqryst ktapplqslk 301 pdevtedisl ireltgqppa pfrlrsd // LOCUS NP_012183 365 aa linear PLN 30-JUN-2025 DEFINITION phosphopantothenate--cysteine ligase CAB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012183 VERSION NP_012183.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179431.2 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08469. On Apr 26, 2011 this sequence version replaced NP_012183.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..365 /product="phosphopantothenate--cysteine ligase CAB2" /EC_number="6.3.2.5" /calculated_mol_wt="41736" Region <72..333 /region_name="PRK05579" /note="bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated" /db_xref="CDD:235513" Region 76..>118 /region_name="PRK06732" /note="phosphopantothenate--cysteine ligase; Validated; cl29327" /db_xref="CDD:475183" CDS 1..365 /gene="CAB2" /locus_tag="YIL083C" /coded_by="NM_001179431.2:1..1098" /experiment="EXISTENCE:direct assay:GO:0004632 phosphopantothenate--cysteine ligase activity [PMID:30653991]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:1990143 CoA-synthesizing protein complex [PMID:23789928]" /experiment="EXISTENCE:genetic interaction:GO:0015937 coenzyme A biosynthetic process [PMID:19266201]" /note="Phosphopantothenoylcysteine synthetase (PPCS); catalyzes the second step of coenzyme A biosynthesis from pantothenate; subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) that contains: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p subunits; null mutant lethality is complemented by human homolog PPCS and by E. coli coaBC, a bifunctional enzyme with PPCS activity" /db_xref="GeneID:854726" /db_xref="SGD:S000001345" ORIGIN 1 mpplpvlnrp qihtsvteis haidrtikee lfpvayttee eqyfktnpkp ayidelikda 61 kefidlqysl krnkivlits ggttvplenn tvrfidnfsa gtrgassaeq flangysvif 121 lhrefsltpy nrsfshsint lfldyidseg kikpefaenv lknkklydky mekeekllll 181 pfttvnqylw slksiaklln nsgclfylaa avsdffvpys rlpqhkiqsg dngkmgannd 241 tegttrttpd gklivnldpv pkflrrlves watqamivsf kletdesmll ykctqaldry 301 nhqlvignll qtrnkqvifv spenrkgdwv rldekhhsie emiipeviar hdkwvahskt 361 klatk // LOCUS NP_012184 1498 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012184 VERSION NP_012184.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181434.4 REFERENCE 1 (residues 1 to 1498) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1498) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1498) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1498) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1498) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1498) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1498) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08470. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1498 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1498 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="172324" Region 16..206 /region_name="Ty3_capsid" /note="Ty3 transposon capsid-like protein; pfam19259" /db_xref="CDD:437091" Region 286..462 /region_name="pepsin_retropepsin_like" /note="Cellular and retroviral pepsin-like aspartate proteases; cl11403" /db_xref="CDD:472175" Site order(336,338,340,364..366,405) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:133136" Site 336..338 /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:133136" Site 336 /site_type="active" /note="Catalytic residue [active]" /db_xref="CDD:133136" Site order(364..367,371..374) /site_type="active" /note="Active site flap [active]" /db_xref="CDD:133136" Region 649..823 /region_name="RT_LTR" /note="Reverse transcriptases (RTs) from retrotransposons and retroviruses which have long terminal repeats (LTRs) in their DNA copies but not in their RNA template. RT catalyzes DNA replication from an RNA template, and is responsible for the replication of...; cd01647" /db_xref="CDD:238825" Site order(712..717,746..747,772,774..775,819..820) /site_type="active" /note="putative active site [active]" /db_xref="CDD:238825" Site order(712..717,746,774) /site_type="other" /note="putative NTP binding site [chemical binding]" /db_xref="CDD:238825" Site 747 /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:238825" Region 915..1034 /region_name="RNase_HI_RT_Ty3" /note="Ty3/Gypsy family of RNase HI in long-term repeat retroelements; cd09274" /db_xref="CDD:260006" Site order(919..922,957..959,962,987,1020,1034) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260006" Region 1117..1177 /region_name="Integrase_H2C2" /note="Integrase zinc binding domain; pfam17921" /db_xref="CDD:465569" Region 1193..1291 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" CDS 1..1498 /locus_tag="YIL082W-A" /coded_by="join(NM_001181434.4:1..851, NM_001181434.4:853..4498)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:854728" /db_xref="SGD:S000003537" ORIGIN 1 msfmdqipgg gnypklpvec lpnfpiqpsl tfrgrndshk lknfiseiml nmsmiswpnd 61 asrivycrrh llnpaaqwan dfvqeqgile itfdtfiqgl yqhfykppdi nkifnaitql 121 seaklgierl nqrfrkiwdr mppdfmteka aimtytrllt ketynivrmh kpetlkdame 181 eayqttalte rffpgfelda dgdtiigatt hlqeeydsdy dsednltqnr yvhtvrtrrs 241 ynkpmsnhrn rrnnnasree ciknrlcfyc kkeghrlnec rarkrvltdl eleskdqqtl 301 fiktlpivhy iaipemdnta ektikiqntk vktlfdsgsp tsfirrdive llkyeiyetp 361 plrfrgfvat ksavtseavt idlkindlqi tlaayildnm dyqllignpi lrrypkilht 421 vlntrespds lkpktyrset vnnvrtysag nrgnprnikl sfaptileat dpksagnrgn 481 prntklslap tileatdpks agnrgdsrtk tlslatttpa aidplttldn pgstqstfaq 541 fpipeeasil eedgkysnvv stiqsvepna tdhsnkdtfc tlpvwlqqky reiirndlpp 601 rpadinnipv khdieikpga rlprlqpyhv tekneqeink ivqklldnkf ivpskspcss 661 pvvlvpkkdg tfrlcvdyrt lnkatisdpf plpridnlls rignaqiftt ldlhsgyhqi 721 pmepkdrykt afvtpsgkye ytvmpfglvn apstfaryma dtfrdlrfvn vylddilifs 781 espeehwkhl dtvlerlkne nlivkkkkck faseeteflg ysigiqkiap lqhkcaaird 841 fptpktvkqa qrflgminyy rrfipncski aqpiqlficd ksqwtekqdk aieklkaalc 901 nspvlvpfnn kanyrlttda skdgigavle evdnknklvg vvgyfsksle saqknypage 961 lellgiikal hhfrymlhgk hftlrtdhis llslqnknep arrvqrwldd latydftley 1021 lagpknvvad aisraiytit petsrpidte swksyyksdp lcsavlihmk eltqhnvtpe 1081 dmsafrsyqk klelsetfrk nysledemiy yqdrlvvpik qqnavmrlyh dhtlfgghfg 1141 vtvtlakisp iyywpklqhs iiqyirtcvq cqlikshrpr lhgllqplpi aegrwldism 1201 dfvtglppts nnlnmilvvv drfskrahfi atrktldatq lidllfryif syhgfprtit 1261 sdrdvrmtad kyqeltkrlg ikstmssanh pqtdgqsert iqtlnrllra yvstniqnwh 1321 vylpqiefvy nstptrtlgk spfeidlgyl pntpaiksdd evnarsftav elakhlkalt 1381 iqtkeqleha qiemetnnnq rrkplllnig dhvlvhrday fkkgaymkvq qiyvgpfrvv 1441 kkindnayel dlnshkkkhr vinvqflksl ytvqtrtqri nqsaplrelr ehtkllhs // LOCUS NP_012186 360 aa linear PLN 30-JUN-2025 DEFINITION TRAMP complex RNA-binding subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_012186 VERSION NP_012186.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179429.1 REFERENCE 1 (residues 1 to 360) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 360) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 360) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 360) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08471. Method: conceptual translation. FEATURES Location/Qualifiers source 1..360 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..360 /product="TRAMP complex RNA-binding subunit" /calculated_mol_wt="41500" Region 9..220 /region_name="AIR1" /note="Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; COG5082" /db_xref="CDD:227414" CDS 1..360 /gene="AIR1" /locus_tag="YIL079C" /coded_by="NM_001179429.1:1..1083" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11489916]" /experiment="EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:15828860|PMID:15935759]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:17643380|PMID:15828860]" /experiment="EXISTENCE:direct assay:GO:1990817 poly(A) RNA polymerase activity [PMID:15935759]" /experiment="EXISTENCE:genetic interaction:GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing [PMID:17410208]" /experiment="EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:15935758|PMID:18007593]" /experiment="EXISTENCE:genetic interaction:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process [PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]" /experiment="EXISTENCE:genetic interaction:GO:1990817 poly(A) RNA polymerase activity [PMID:15935759]" /note="Zinc knuckle protein; involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; AIR1 has a paralog, AIR2, that arose from the whole genome duplication; although Air1p and Air2p are homologous TRAMP subunits, they have nonredundant roles in regulation of substrate specificity of the exosome" /db_xref="GeneID:854731" /db_xref="SGD:S000001341" ORIGIN 1 mstllseves idtlpyvkdt tptgsdsssf nkllapsied vdanpeelrt lrgqgryfgi 61 tdydsngaim eaepkcnncs qrghlkrncp hvictycgfm ddhysqhcpk aiictncnan 121 ghyksqcphk wkkvfctlcn skrhsrercp siwrsyllkt kdanqgdfdf qtvfcyncgn 181 aghfgddcae rrssrvpntd gsafcgdnla tkfkqhyfnq lkdykreasq rqhfdnehef 241 nlldyeyndd aydlpgsrty rdkmkwkgkv qstrnknssn nryessnnrk kkspfsaqny 301 kvtknkrvqt hpldfprssq nnrtndyssq fsynrddfpk gpknkrgrss snksqrngry // LOCUS NP_116578 734 aa linear PLN 30-JUN-2025 DEFINITION threonine--tRNA ligase THS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_116578 VERSION NP_116578.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179428.3 REFERENCE 1 (residues 1 to 734) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 734) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 734) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 734) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 734) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 734) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 734) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08472. On Jul 30, 2012 this sequence version replaced NP_116578.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..734 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..734 /product="threonine--tRNA ligase THS1" /EC_number="6.1.1.3" /calculated_mol_wt="84390" Region 46..728 /region_name="PLN02908" /note="threonyl-tRNA synthetase" /db_xref="CDD:178496" CDS 1..734 /gene="THS1" /locus_tag="YIL078W" /coded_by="NM_001179428.3:1..2205" /experiment="EXISTENCE:direct assay:GO:0004829 threonine-tRNA ligase activity [PMID:8143729]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006435 threonyl-tRNA aminoacylation [PMID:8143729]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:2995918]" /note="Threonyl-tRNA synthetase involved in tRNA aminoacylation; mRNA binding protein that preferentially binds to the mRNA of RNAPI subunits and DNA binding proteins; binds to an anticodon stem loop-like structure in RPC10 and impacts its translation; cytoplasmic protein; human homolog TARS can complement a yeast null mutant" /db_xref="GeneID:854732" /db_xref="SGD:S000001340" ORIGIN 1 msaseagvte qvkklsvkds sndavkpnkk enkkskqqsl yldpeptfie eriemfdrlq 61 keyndkvasm prvplkivlk dgavkeatsw ettpmdiakg isksladrlc iskvngqlwd 121 ldrpfegean eeiklelldf esdegkkvfw hssahvlges cechlgahic lgpptddgff 181 yemavrdsmk disespertv sqadfpgleg vaknvikqkq kferlvmske dllkmfhysk 241 yktylvqtkv pdggattvyr cgklidlcvg phiphtgrik afkllknssc yflgdatnds 301 lqrvygisfp dkklmdahlk flaeasmrdh rkigkeqelf lfnemspgsc fwlphgtriy 361 ntlvdllrte yrkrgyeevi tpnmynsklw etsghwanyk enmftfevek etfglkpmnc 421 pghclmfksr ersyrelpwr vadfgvihrn efsgalsglt rvrrfqqdda hifcthdqie 481 seienifnfl qyiygvfgfe fkmelstrpe kyvgkietwd aaesklesal kkwggnwein 541 agdgafygpk idimisdalr rwhqcatiql dfqlpnrfel efkskdqdse syerpvmihr 601 ailgsvermt ailtehfagk wpfwlsprqv lvvpvgvkyq gyaedvrnkl hdagfyadvd 661 ltgntlqkkv rngqmlkynf ifivgeqemn eksvnirnrd vmeqqgknat vsveevlkql 721 rnlkdekrgd nvla // LOCUS NP_012188 320 aa linear PLN 30-JUN-2025 DEFINITION Rci37p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012188 VERSION NP_012188.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179427.3 REFERENCE 1 (residues 1 to 320) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 320) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 320) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 320) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08473. On Jul 30, 2012 this sequence version replaced NP_012188.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..320 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..320 /product="Rci37p" /calculated_mol_wt="36815" Region 33..202 /region_name="DUF1689" /note="Protein of unknown function (DUF1689); pfam07954" /db_xref="CDD:369614" CDS 1..320 /gene="RCI37" /locus_tag="YIL077C" /gene_synonym="MRX17" /coded_by="NM_001179427.3:1..963" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961]" /note="Protein that associates with the large mitoribosomal subunit; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)" /db_xref="GeneID:854733" /db_xref="SGD:S000001339" ORIGIN 1 mlgkeeeqqy gqngkgmene lpfmkrpwfk kayenaiefh ekdelldard rlelskayrs 61 iakaemwggw lgfsavfltp fayryyktka ikgvkvprnf vlgvmalffa tnfagrsmyt 121 rqlnerdptg vlkdnysnky gdndfgafqh dqtkeiprnq rqynmmrlld sgspsrwsmy 181 fyityqnper rlpdpkvklq qmkkggvfng spfmnqrdpi glyrnkgrks pdpiegeqnd 241 spvlssweki rngdnsssss wenirntsrd qsqesdasvd hesdifisgf sddgnatdns 301 ssddkyqrll qsgryggnrs // LOCUS NP_012189 296 aa linear PLN 30-JUN-2025 DEFINITION coatomer subunit epsilon [Saccharomyces cerevisiae S288C]. ACCESSION NP_012189 VERSION NP_012189.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179426.1 REFERENCE 1 (residues 1 to 296) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 296) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 296) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 296) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08474. On Nov 30, 2005 this sequence version replaced NP_012189.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..296 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..296 /product="coatomer subunit epsilon" /calculated_mol_wt="33698" Region 4..293 /region_name="Coatomer_E" /note="Coatomer epsilon subunit; pfam04733" /db_xref="CDD:398419" CDS 1..296 /gene="SEC28" /locus_tag="YIL076W" /gene_synonym="ANU2" /coded_by="NM_001179426.1:1..891" /experiment="EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:21435344]" /experiment="EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:27184763]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10532354]" /experiment="EXISTENCE:mutant phenotype:GO:0006901 vesicle coating [PMID:9463377]" /experiment="EXISTENCE:mutant phenotype:GO:0030126 COPI vesicle coat [PMID:9463377]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17101773]" /experiment="EXISTENCE:physical interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17101773]" /note="Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854734" /db_xref="SGD:S000001338" ORIGIN 1 mdyfnikqny ytgnfvqclq eiekfskvtd ntllfykakt llalgqyqsq dptsklgkvl 61 dlyvqfldtk nieelenllk dkqnspyely llataqailg dldksletcv egidndeaeg 121 ttellllaie vallnnnvst astifdnytn aiedtvsgdn emilnlaesy ikfatnketa 181 tsnfyyyeel sqtfptwktq lgllnlhlqq rniaeaqgiv elllsdyysv eqkenavlyk 241 ptflanqitl almqgldted ltnqlvkldh ehafikhhqe idakfdelvr kydtsn // LOCUS NP_012190 945 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle base subunit RPN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012190 VERSION NP_012190.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179425.1 REFERENCE 1 (residues 1 to 945) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 945) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 945) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 945) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 945) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 945) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 945) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08475. Method: conceptual translation. FEATURES Location/Qualifiers source 1..945 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..945 /product="proteasome regulatory particle base subunit RPN2" /calculated_mol_wt="104101" Region 1..945 /region_name="RPN2" /note="26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]; COG5116" /db_xref="CDD:227446" Region 533..557 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(549..550,553,556..557,585..586,589,592..593,619..620, 623,626..627,630,654..655,658,661..662,697..698,701, 704..705) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 567..595 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 601..631 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 636..662 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 675..706 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..945 /gene="RPN2" /locus_tag="YIL075C" /gene_synonym="SEN3" /coded_by="NM_001179425.1:1..2838" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:15210724]" /experiment="EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:17911101]" /experiment="EXISTENCE:mutant phenotype:GO:0004175 endopeptidase activity [PMID:7565784]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:7565784]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:10688918]" /note="Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854735" /db_xref="SGD:S000001337" ORIGIN 1 mslttaapll allrenqdsv ktyalesinn vvdqlwseis nelpdiealy dddtfsdrem 61 aaliaskvyy nlgeyesavk yalaakdrfd ideksqfvet ivsksiemyv qeaskqytkd 121 eqfytkdiid pkltsiferm iekclkasel klalgialeg yrldiiesal kskldqdsts 181 envkiinyll tlaittvtns kfrssilrks fdflmnmpnc dyltlnkvvv nlndaglalq 241 lfkklkeend eglsaqiafd lvssasqqll eilvteltaq gydpallnil sglptcdyyn 301 tfllnnknid igllnkskss ldgkfslfht avsvangfmh agttdnsfik anlpwlgkaq 361 nwakftatas lgvihkgnll egkkvmapyl pgsrassrfi kggslyglgl iyagfgrdtt 421 dylkniiven sgtsgdedvd vllhgaslgi glaamgsani evyealkevl yndsatsgea 481 aalgmglcml gtgkpeaihd mftysqetqh gnitrglavg lalinygrqe laddlitkml 541 asdesllryg gaftialaya gtgnnsavkr llhvavsdsn ddvrraavia lgfvllrdyt 601 tvprivqlls kshnahvrcg tafalgiaca gkglqsaidv ldpltkdpvd fvrqaamial 661 smiliqqtek lnpqvadink nflsvitnkh qeglakfgac vaqgimnagg rnvtiqlena 721 dtgtldtksv vglvmfsqfw ywfplahfls lsftpttvig irgsdqaipk fqmncyaked 781 afsyprmyee asgkevekva tavlsttara karakktkke kgpneeekkk eheekekere 841 tnkkgiketk endeefyknk ysskpykvdn mtrilpqqsr yisfikddrf vpvrkfkgnn 901 gvvvlrdrep kepvalietv rqmkdvnapl ptpfkvddnv dfpsa // LOCUS NP_012191 469 aa linear PLN 30-JUN-2025 DEFINITION phosphoglycerate dehydrogenase SER33 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012191 VERSION NP_012191.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179424.1 REFERENCE 1 (residues 1 to 469) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 469) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 469) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 469) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08476. Method: conceptual translation. FEATURES Location/Qualifiers source 1..469 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..469 /product="phosphoglycerate dehydrogenase SER33" /EC_number="1.1.1.95" /EC_number="1.1.1.399" /calculated_mol_wt="51057" Region 59..469 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" Site order(107..108,130..132,155) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:240653" Site order(131,153,155,159,205..209,227..229,232,257..259, 263..264,267,285..287,311,347,349..350) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:240653" Site order(157..158,161..162,164..166,168..169,172,174,177..178, 181..182,184,186..197,199,219..220,313,316..317,320, 331..332,336..337,339,342..349,351..354,356) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:240653" CDS 1..469 /gene="SER33" /locus_tag="YIL074C" /coded_by="NM_001179424.1:1..1410" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0061759 alpha-ketoglutarate reductase activity [PMID:26774271]" /experiment="EXISTENCE:genetic interaction:GO:0061759 alpha-ketoglutarate reductase activity [PMID:26774271]" /experiment="EXISTENCE:mutant phenotype:GO:0004617 phosphoglycerate dehydrogenase activity [PMID:12525494]" /experiment="EXISTENCE:mutant phenotype:GO:0006564 L-serine biosynthetic process [PMID:12525494]" /experiment="EXISTENCE:mutant phenotype:GO:0061759 alpha-ketoglutarate reductase activity [PMID:26774271]" /note="3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase; 3PG dehydrogenase that catalyzes the first step in serine and glycine biosynthesis; also functions as an alpha-ketoglutarate reductase, converting alpha-ketoglutarate to D-2-hydroxyglutarate (D-2HG); localizes to the cytoplasm; SER33 has a paralog, SER3, that arose from the whole genome duplication" /db_xref="GeneID:854736" /db_xref="SGD:S000001336" ORIGIN 1 msysaadnlq dsfqramnfs gspgavstsp tqsfmntlpr rvsitkqpka lkpfstgdmn 61 illlenvnat aikifkdqgy qvefhksslp edeliekikd vhaigirskt rltekilqha 121 rnlvcigcfc igtnqvdlky aaskgiavfn spfsnsrsva elvigeiisl arqlgdrsie 181 lhtgtwnkva arcwevrgkt lgiigyghig sqlsvlaeam glhvlyydiv timalgtarq 241 vstldellnk sdfvtlhvpa tpetekmlsa pqfaamkdga yvinasrgtv vdipsliqav 301 kankiagaal dvyphepakn gegsfndeln swtselvslp niiltphigg steeaqssig 361 ievatalsky inegnsvgsv nfpevslksl dydqentvrv lyihrnvpgv lktvndilsd 421 hniekqfsds hgeiaylmad issvnqseik diyeklnqts akvsirlly // LOCUS NP_012192 975 aa linear PLN 30-JUN-2025 DEFINITION Spo22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012192 VERSION NP_012192.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179423.1 REFERENCE 1 (residues 1 to 975) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 975) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 975) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 975) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 975) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 975) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 975) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08477. On Oct 2, 2003 this sequence version replaced NP_012192.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..975 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..975 /product="Spo22p" /calculated_mol_wt="112304" Region 194..476 /region_name="SPO22" /note="Meiosis protein SPO22/ZIP4 like; pfam08631" /db_xref="CDD:462542" CDS 1..975 /gene="SPO22" /locus_tag="YIL073C" /gene_synonym="ZIP4" /coded_by="NM_001179423.1:1..2928" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0033235 positive regulation of protein sumoylation [PMID:23326245]" /experiment="EXISTENCE:mutant phenotype:GO:0090173 regulation of synaptonemal complex assembly [PMID:16740482]" /note="Meiosis-specific protein essential for chromosome synapsis; involved in completion of nuclear divisions during meiosis; induced early in meiosis" /db_xref="GeneID:854737" /db_xref="SGD:S000001335" ORIGIN 1 msdhnvnstf rktlvelcet atwitsqvya aknlekndli tvdnkisaly piaekydrsf 61 rtttvildee lilklenaas slwnsltiam kaekasdkyf nevfckckif atkllsihea 121 lfrtntnllr nfkcyissfk saseyrfddl itntqqhsek ylqiinenve sfsneektef 181 kkltfefylv nfqlylsend ldtaniytak vnitdnskym dadllielcr miynstvmlk 241 einnpetqlv dvniisflkd vekylelpve nlkshtdysn lkysvlifma nclveghpqa 301 seleqcdhyl sllqneypnk vdpfilainl tkrrnivnpa etieeilmrm imsvdvisnf 361 qaviasindl skmntkfsiv cldyllinkl nskndskflg kaicsrflit tqsktmndse 421 iaeslenfst qmerivsepl tkhaisciit llwntgkkle kmekyvvsir fyklalkdii 481 sqnysdrgki qralqvvynk iedysntvrv yqdmdevdrq splcqllmlq sfladdktee 541 altclqkiks sedekstdal ilavaeckrk tdlsvqgllm ifdklqsksn sqtisstsss 601 qtlsilrytl qmivkvseee pletfinylp tvqkllqkav eflktvklln qlppdvekea 661 iyqqsvavne iewfasfsyn vavkclvdqs cesisefpqy ciqfidlipv qdftfpkmyh 721 ftywrfkati lqliiakeka kqdqhqkdwd iyekseelvn sinvmkksse fkdgssledr 781 ntlhecflea ltihlesalm mpdqtrildi lkktelyqds rvdallidis snmedlpkgv 841 lieiletvlk rnmgpevker elcswlrill enainlnhev elrildrvlk ilninqsslq 901 dtdgvlqtel etiatycwni gvnyiikdnk sngivwckhs mgfanmvneg lqeqlyslwe 961 slassanidi nsiak // LOCUS NP_012193 605 aa linear PLN 30-JUN-2025 DEFINITION Hop1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012193 VERSION NP_012193.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179422.3 REFERENCE 1 (residues 1 to 605) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 605) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 605) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 605) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08478. On Jul 30, 2012 this sequence version replaced NP_012193.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..605 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..605 /product="Hop1p" /calculated_mol_wt="68745" Region 22..244 /region_name="HORMA" /note="HORMA domain; pfam02301" /db_xref="CDD:460526" CDS 1..605 /gene="HOP1" /locus_tag="YIL072W" /coded_by="NM_001179422.3:1..1818" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:17027027]" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:2107981]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:38332377]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141|PMID:23841450]" /experiment="EXISTENCE:genetic interaction:GO:0051598 meiotic recombination checkpoint signaling [PMID:10848609]" /experiment="EXISTENCE:mutant phenotype:GO:0003682 chromatin binding [PMID:38332377]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:2107981|PMID:8207053]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:2653960]" /experiment="EXISTENCE:mutant phenotype:GO:0010846 activation of reciprocal meiotic recombination [PMID:38332377]" /experiment="EXISTENCE:physical interaction:GO:0000800 lateral element [PMID:9060462]" /note="Meiosis-specific HORMAD protein required for chromosome synapsis; displays Red1p-dependent localization to unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; binds chromatin to regulate initiation of meiotic recombination; promotes intra- and intermolecular synapsis between dsDNA molecules and folds DNA into rigid protein-DNA filaments in vitro; contains a HORMA domain, and a chromatin-binding region made up of PHD and winged helix-turn-helix domains" /db_xref="GeneID:854738" /db_xref="SGD:S000001334" ORIGIN 1 msnkqlvkpk tetkteitte qsqkllqtml tmsfgclafl rglfpddifv dqrfvpekve 61 knynkqntsq nnsikiktli rgksaqadll ldwlekgvfk sirlkclkal slgifledpt 121 dllenyifsf dydeennvni nvnlsgnkkg sknadpenet islldsrrmv qqlmrrfiii 181 tqsleplpqk kfltmrlmfn dnvdedyqpe lfkdatfdkr atlkvptnld ndaidvgtln 241 tkhhkvalsv lsaatssmek agntnfirvd pfdlilqqqe enkleesvpt kpqnfvtsqt 301 tnvlgnllns sqasiqptqf vsnnpvtgic scecglevpk aatvlktcks crktlhgicy 361 gnflhssiek cftcifgpsl dtkwskfqdl mmirkvfrfl vrkkkgfpas itelidsfin 421 vedqnnevke rvafalfvff ldetlcldng gkpsqtiryv tssvlvdvkg ivipntrkql 481 nvnheykwhf ttsspkaesf yqevlpnsrk qveswlqdit nlrkvyseal spsstlqeld 541 lnsslptqdp iisgqkrrry dldeyleedk ssvvndtika kdfdesvpak irkisvskkt 601 lksnw // LOCUS NP_085069 444 aa linear PLN 30-JUN-2025 DEFINITION Pci8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_085069 VERSION NP_085069.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179421.3 REFERENCE 1 (residues 1 to 444) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 444) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 444) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 444) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08479. On Jul 30, 2012 this sequence version replaced NP_085069.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..444 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..444 /product="Pci8p" /calculated_mol_wt="51157" Region 296..387 /region_name="PINT" /note="motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; smart00088" /db_xref="CDD:214509" CDS 1..444 /gene="PCI8" /locus_tag="YIL071C" /gene_synonym="CSN11; YIH1; YIL071W" /coded_by="NM_001179421.3:1..1335" /experiment="EXISTENCE:direct assay:GO:0008180 COP9 signalosome [PMID:12446563]" /experiment="EXISTENCE:mutant phenotype:GO:0000338 protein deneddylation [PMID:12186635|PMID:12446563]" /note="Possible shared subunit of Cop9 signalosome (CSN) and eIF3; binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain" /db_xref="GeneID:854739" /db_xref="SGD:S000001333" ORIGIN 1 mfhgakgpll ierighllsi nygekeerkr wamqgisylq evqctstpyl eilveesglr 61 pvsllnsqlv gkphfsllgg fdeniardii shnfqnaifq meseevpltk ryqhlekitq 121 isllcknfkg ieeieynvkn iiqgrknfdm lnsmekdris hevvqddsfs llriqmllcv 181 syflqeryfd cctkfftmmt sepltlkvls ehldcmnfis keefimmvni svlisipldn 241 yddfiylsdl kqffqmtpll vnclellint nfnkffkiwh geinkicmes lflepswsss 301 aavimrckiy ffylriskkl qfsylsstlg idledikeel tkliisgqln feidgdvihf 361 edssilqsiv neisrngtmi nevidklkne ntdlkdiiqg nplmysggnn tatiinness 421 ddmdidevnd rsdisdsegg lfec // LOCUS NP_012194 266 aa linear PLN 30-JUN-2025 DEFINITION Mam33p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012194 VERSION NP_012194.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179420.1 REFERENCE 1 (residues 1 to 266) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 266) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 266) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 266) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08480. Method: conceptual translation. FEATURES Location/Qualifiers source 1..266 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..266 /product="Mam33p" /calculated_mol_wt="30001" Region 57..265 /region_name="MAM33" /note="Mitochondrial glycoprotein; pfam02330" /db_xref="CDD:460534" CDS 1..266 /gene="MAM33" /locus_tag="YIL070C" /coded_by="NM_001179420.1:1..801" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:9305894]" /experiment="EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:31053642]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:9305894]" /experiment="EXISTENCE:mutant phenotype:GO:1902775 mitochondrial large ribosomal subunit assembly [PMID:31053642]" /note="Acidic protein that forms a homo-oligomeric complex in the mitochondrial matrix; binds to a subset of unassembled mitoribosome large subunit (mtLSU) proteins and is required for mtLSU assembly; subunit of a complex containing Mrx6p, Pim1p, and Pet20p that may regulate mtDNA replication; related to the human complement receptor gC1q-R" /db_xref="GeneID:854740" /db_xref="SGD:S000001332" ORIGIN 1 mflrsvnrav trsilttpkp avvksswrvf tvanskrcft paaimrnqet qrvgdilqse 61 lkieketlpe stsldsfndf lnkykfslve tpgkneaeiv rrtesgetvh vffdvaqian 121 lpynnamden teqnedgine ddfdalsdnf anvnvviske sasepavsfe llmnlqegsf 181 yvdsatpyps vdaalnqsae aeitrelvyh gppfsnldee lqesleayle srgvneelas 241 fisaysefke nneyiswlek mkkffh // LOCUS NP_012195 135 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS24 RPS24B [Saccharomyces cerevisiae S288C]. ACCESSION NP_012195 VERSION NP_012195.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179419.1 REFERENCE 1 (residues 1 to 135) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 135) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 135) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 135) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08481. Method: conceptual translation. FEATURES Location/Qualifiers source 1..135 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..135 /product="40S ribosomal protein eS24 RPS24B" /calculated_mol_wt="15198" Region 1..123 /region_name="PTZ00071" /note="40S ribosomal protein S24; Provisional" /db_xref="CDD:240256" CDS 1..135 /gene="RPS24B" /locus_tag="YIL069C" /gene_synonym="RPS24EB" /coded_by="NM_001179419.1:1..408" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication" /db_xref="GeneID:854741" /db_xref="SGD:S000001331" ORIGIN 1 msdavtirtr kvisnpllar kqfvvdvlhp nranvskdel reklaevyka ekdavsvfgf 61 rtqfgggksv gfglvynsva eakkfeptyr lvryglaekv ekasrqqrkq kknrdkkifg 121 tgkrlakkva rrnad // LOCUS NP_012196 805 aa linear PLN 30-JUN-2025 DEFINITION SNARE-binding exocyst subunit SEC6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012196 VERSION NP_012196.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179418.1 REFERENCE 1 (residues 1 to 805) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 805) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 805) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 805) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 805) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08482. Method: conceptual translation. FEATURES Location/Qualifiers source 1..805 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..805 /product="SNARE-binding exocyst subunit SEC6" /calculated_mol_wt="93297" Region 2..805 /region_name="SEC6" /note="Exocyst complex subunit SEC6 [Intracellular trafficking and secretion]; COG5173" /db_xref="CDD:227500" CDS 1..805 /gene="SEC6" /locus_tag="YIL068C" /coded_by="NM_001179418.1:1..2418" /experiment="EXISTENCE:direct assay:GO:0000145 exocyst [PMID:8978675|PMID:7615633]" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:15835919|PMID:22114349]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:19073882]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:19073882]" /experiment="EXISTENCE:direct assay:GO:0035544 negative regulation of SNARE complex assembly [PMID:22114349|PMID:15835919]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:genetic interaction:GO:0035544 negative regulation of SNARE complex assembly [PMID:22114349]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:6996832]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:mutant phenotype:GO:0051601 exocyst localization [PMID:19073882]" /experiment="EXISTENCE:physical interaction:GO:0000149 SNARE binding [PMID:15835919|PMID:22114349]" /experiment="EXISTENCE:physical interaction:GO:0035544 negative regulation of SNARE complex assembly [PMID:15835919|PMID:22114349]" /note="Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; binds to SNARE complexes binteracting with Sec9p" /db_xref="GeneID:854742" /db_xref="SGD:S000001330" ORIGIN 1 mssdplqqvc dlikgdlsle rvrdikeqll keksvveyql nkesdkyyge veeslkllnl 61 sknsvtsikq qinevnklgn dnrfainryd ilfratklye tvnttssiyd riynfvalme 121 hierllvael aedaletgcp hlleihfllt sardfqeqvv vmakeateda qrtvmklfsr 181 lsgiiskfdk lldgltydiv emaraeqisl airlfkiydl eeredlriea irniikkkei 241 eiekssikkl pnskntarlq detpkvieyp tnkglyqeim sgtistrtap rgykhfling 301 innsisemfg emrekyvgdq kfdvldnmdw ifneliivke hianccpphw nifevyfdqy 361 ykelhslitd lvesepetii ildilafdkt fqdtlkqdfg ftksevksvi gdkeketlfk 421 dylnlivvkm tewignleka efdvflerst pphsdsdgll fldgtktcfq mftqqvevaa 481 gtnqakilvg vverfsdllt krqknwiski seeikkqiny nhkydidpes itpedecpgg 541 lveyliavsn dqmkaadyav aisskygklv skvyekqitn hlegtldgfa evaqcsslgl 601 itlmfddlrk pyqeifsktw ymgsqaqqia dtldeylldi kpqmnsvlfv nfidnviget 661 iikfltalsf ehsfknknnk fleamkrdfe ifyqlfvkvl dgneskdtli tqnftvmeff 721 mdlscepids ildiwqkyle vywdsridll vgilkcrkdv ssserkkivq qatemlheyr 781 rnmeangvdr eptlmrrfvl efekq // LOCUS NP_012197 678 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL067C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012197 VERSION NP_012197.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179417.1 REFERENCE 1 (residues 1 to 678) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 678) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 678) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 678) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08483. Method: conceptual translation. FEATURES Location/Qualifiers source 1..678 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..678 /product="uncharacterized protein" /calculated_mol_wt="75352" Region <238..278 /region_name="LCCL" /note="LCCL domain; cl02694" /db_xref="CDD:445888" CDS 1..678 /locus_tag="YIL067C" /coded_by="NM_001179417.1:1..2037" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /note="Uncharacterized hypothetical protein" /db_xref="GeneID:854743" /db_xref="SGD:S000001329" ORIGIN 1 mgvhfddnan ttweatdpgv ssdcdgqhrv tesiqlqnfs ntdmesmlde egrenskskw 61 lllkrkhpiq kfiervwngp vepsdeppsf pkrwgwlkki ddfpqttfkt kipsklirll 121 llivyccfwm rifysliypy likppyfhpn dgsekipils lscnsylnwe gtnnecglna 181 kncgpldnke ymircpalcd rggwtysaia vgnrrvkytg yeigggalfs eedpmvvsyp 241 yrsdsfpcas avhagvispf yggctkvsmq gaqnsfpskk gmyntgfsva fnsffpgsys 301 frdiqggils gcydpraavv alnmlfglpi fylydsiygy wintivgywt lvlsldppll 361 tdahdpasvy elfsvgfqrl lplcfvlyvv wksavkrtle ngspiakvil wyptfwlgis 421 nnvtfdrlpv drltttdlke qagaltavgs iaatiltcav iqayslwksg rfkkyfkiyi 481 cfigglialg slpglnlrih hyilgsilvp gcatrgssay lfqgilvgli lsgvarwdfa 541 sivetdtall rgeagaslkp pildfnddqn hslswhlnat dpvidqigni dgfslllndv 601 evyvgknetv sidvlrmenp alaqmmddal dasngtidly lrvarasvrs ptnrgdytna 661 gvlqwpngmw qkpepgvs // LOCUS NP_012198 869 aa linear PLN 30-JUN-2025 DEFINITION ribonucleotide-diphosphate reductase subunit RNR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012198 VERSION NP_012198.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179416.3 REFERENCE 1 (residues 1 to 869) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 869) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 869) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 869) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08484. On Jul 30, 2012 this sequence version replaced NP_012198.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..869 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..869 /product="ribonucleotide-diphosphate reductase subunit RNR3" /EC_number="1.17.4.1" /calculated_mol_wt="97384" Region 1..775 /region_name="PLN02437" /note="ribonucleoside--diphosphate reductase large subunit" /db_xref="CDD:178056" Site order(202..203,217..218,247,426,428,430,445,606..611) /site_type="active" /db_xref="CDD:153088" Site order(214,228..229,232,235..236,239..240,243,258,270, 274..275,277..278,281..282,285..289) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153088" Site order(218,426,428,430,443,741..742) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:153088" Site order(226..228,231,243,256,270,275) /site_type="active" /note="effector binding site [active]" /db_xref="CDD:153088" Site order(336,339..340,342..343,386,390,397,720..722,724..725, 729..730,732..733) /site_type="active" /note="R2 peptide binding site [active]" /db_xref="CDD:153088" CDS 1..869 /gene="RNR3" /locus_tag="YIL066C" /gene_synonym="DIN1; RIR3" /coded_by="NM_001179416.3:1..2610" /experiment="EXISTENCE:direct assay:GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [PMID:11893751]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12732713]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0009263 deoxyribonucleotide biosynthetic process [PMID:5459124]" /note="Minor isoform of large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits; RNR3 has a paralog, RNR1, that arose from the whole genome duplication" /db_xref="GeneID:854744" /db_xref="SGD:S000001328" ORIGIN 1 myvikrdgrk epvqfdkits ritrlsygld pnridavkvt qriisgvysg vttveldnla 61 aetcaymttv hpdyatlaar iaisnlhkqt tkqfskvied lhdwinpatg khapmisdei 121 ynivmenkdt lnsaivydrd fqytyfgfkt lersyllrln gevaerpqhl vmrvalgihg 181 sdiesvlkty nlmslryfth asptlfnagt phpqmsscfl iamkddsieg iydtlkecam 241 isktaggvgl hinnirstgs yiagtngtsn glipmirvfn ntaryvdqgg nkrpgafalf 301 lepwhadifd fvdirkthgk eeirardlfp alwipdlfmk rvqedgpwtl fspsaapgld 361 dvwgdefeel ytryeregrg ktikaqklwy ailqaqtetg tpfmvykdac nrktnqqnlg 421 tikssnlcce iveysspdet avcnlasial pafvevsedg ktasynferl heiakvithn 481 lnrvidrnyy pvpearnsnm khrpialgvq gladtymmlr lpfeseeaqt lnkqifetiy 541 hatleascel aqkegkystf egspaskgil qfdmwnakpf gmwdwetlrk divkhglrns 601 ltmapmptas tsqilgynec fepvtsnmys rrvlsgefqv vnpyllrdlv dlgiwddsmk 661 qylitqngsi qglpnvpqel kelyktvwei sqktiinmaa draiyidqsh slnlflqaps 721 mgkitsmhfy gwkkglktgm yylrtqaasa aiqftidqev adqaathias vseldrpvyv 781 pkgtkfseqk aasaltessd nekdaspvps eqssvssams nvkledsvap avptetiked 841 sdekkcdiyn ekviactapt peacescsg // LOCUS NP_012199 155 aa linear PLN 30-JUN-2025 DEFINITION Fis1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012199 VERSION NP_012199.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179415.3 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08485. On Jul 30, 2012 this sequence version replaced NP_012199.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..155 /product="Fis1p" /calculated_mol_wt="17602" Region 16..129 /region_name="Fis1" /note="Mitochondrial Fission Protein Fis1, cytosolic domain; cd12212" /db_xref="CDD:276936" Site order(21,24..25,28,39..41,43..44,47,56,59..60,62..63,66, 69..70,72,75..78,80,82,90,92,95,98..99,102) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:276936" Region 39..71 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276936" Region 75..106 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276936" CDS 1..155 /gene="FIS1" /locus_tag="YIL065C" /gene_synonym="MDV2" /coded_by="NM_001179415.3:1..468" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:15809300|PMID:16407407|PMID:11038183]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:16968746]" /experiment="EXISTENCE:genetic interaction:GO:0016559 peroxisome fission [PMID:18445678]" /experiment="EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:11038183|PMID:11038182]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:16968746]" /note="Protein involved in mitochondrial fission and peroxisome abundance; may have a distinct role in tethering protein aggregates to mitochondria in order to retain them in the mother cell; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation" /db_xref="GeneID:854745" /db_xref="SGD:S000001327" ORIGIN 1 mtkvdfwptl kdayeplypq qleilrqqvv seggptatiq srfnyawgli kstdvnderl 61 gvkiltdiyk eaesrrrecl yyltigcykl geysmakryv dtlfehernn kqvgalksmv 121 edkiqketlk gvvvaggvla gavavasffl rnkrr // LOCUS NP_012200 229 aa linear PLN 30-JUN-2025 DEFINITION Efm4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012200 VERSION NP_012200.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179414.2 REFERENCE 1 (residues 1 to 229) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 229) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 229) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 229) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08486. On Jun 28, 2024 this sequence version replaced NP_012200.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..229 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..229 /product="Efm4p" /calculated_mol_wt="25355" Region 63..214 /region_name="Methyltransf_31" /note="Methyltransferase domain; pfam13847" /db_xref="CDD:463998" CDS 1..229 /gene="EFM4" /locus_tag="YIL064W" /gene_synonym="SEE1" /coded_by="NM_001179414.2:1..690" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016279 protein-lysine N-methyltransferase activity [PMID:20510667]" /note="Lysine methyltransferase; involved in the dimethylation of eEF1A (Tef1p/Tef2p) at lysine 316; sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport" /db_xref="GeneID:854746" /db_xref="SGD:S000001326" ORIGIN 1 mqgtadlsts klgtkkywde lyalelenfr rnpqdtgdcw fsdsdaeqkm idflvdniga 61 yrisenasvv dlgtgnghml felhqtefqg klvgidysee svklasniae atgvdnfisf 121 qqadifsgdw kpgkydivld kgtldaisls gmkingkldv vdvyagvver ilkkdgifli 181 tscnftqdel vkiietdnlk mwktikypvf qfggvqgati csvafvkqn // LOCUS NP_012201 327 aa linear PLN 30-JUN-2025 DEFINITION Yrb2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012201 VERSION NP_012201.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179413.1 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08487. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..327 /product="Yrb2p" /calculated_mol_wt="35923" Region 193..321 /region_name="RanBD" /note="Ran-binding domain; smart00160" /db_xref="CDD:197549" Site order(221,223..225,230..235,253,255,257..258,262..264,267, 269,273,277,291,293,303,307) /site_type="other" /note="putative RAN binding site [polypeptide binding]" /db_xref="CDD:270001" CDS 1..327 /gene="YRB2" /locus_tag="YIL063C" /coded_by="NM_001179413.1:1..984" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247|PMID:9395535|PMID:22932476|PMID:9121474]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:12082158]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:9636166]" /note="hypothetical protein; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; relocalizes to the cytosol in response to hypoxia; not essential for viability" /db_xref="GeneID:854747" /db_xref="SGD:S000001325" ORIGIN 1 msetnggnaa rensevkqta venpidkldg tpkrprekdq deqaeetsdk seapnkndee 61 kkeegkkdqe pshkkikvdd gktvesgive ddkkedkfvf gaaskfgtgf gvakkdtkdg 121 dattsteslp asdsktkkpf afgsglsfgs gfnilknkte nnsesekkat dvdkdkvhsg 181 seqlanased tkdkpkplkl qkqevksgee seeciyqvna klyqlsnike gwkergvgii 241 kinkskddve ktrivmrsrg ilkvilniql vkgftvqkgf tgslqsekfi rllavddngd 301 paqyaiktgk kettdelyni ivksvpk // LOCUS NP_012202 154 aa linear PLN 30-JUN-2025 DEFINITION Arc15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012202 VERSION NP_012202.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179412.1 REFERENCE 1 (residues 1 to 154) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 154) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 154) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 154) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08488. Method: conceptual translation. FEATURES Location/Qualifiers source 1..154 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..154 /product="Arc15p" /calculated_mol_wt="17003" Region 4..152 /region_name="P16-Arc" /note="ARP2/3 complex 16 kDa subunit (p16-Arc); pfam04699" /db_xref="CDD:461399" CDS 1..154 /gene="ARC15" /locus_tag="YIL062C" /coded_by="NM_001179412.1:1..465" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:10377407|PMID:9210376]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:11248049]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:10377407]" /note="Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; has mRNA binding activity" /db_xref="GeneID:854748" /db_xref="SGD:S000001324" ORIGIN 1 meadwrridi dafdpesgrl taadlvppye ttvtlqelqp rmnqlrslat sgdslgavql 61 lttdppysad aptkeqyfks vlealtqvrq adignviknl sdsqrdvlvk ylykgmsvpq 121 gqkqggvlla wleritqvsg vtpivhyisd rrtv // LOCUS NP_012203 300 aa linear PLN 30-JUN-2025 DEFINITION U1 snRNP complex subunit SNP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012203 VERSION NP_012203.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179411.1 REFERENCE 1 (residues 1 to 300) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 300) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 300) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 300) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08489. Method: conceptual translation. FEATURES Location/Qualifiers source 1..300 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..300 /product="U1 snRNP complex subunit SNP1" /calculated_mol_wt="34316" Region 6..97 /region_name="U1snRNP70_N" /note="U1 small nuclear ribonucleoprotein of 70kDa MW N terminal; pfam12220" /db_xref="CDD:432406" Region 89..201 /region_name="RRM_SNP1_like" /note="RNA recognition motif (RRM) found in Saccharomyces cerevisiae U1 small nuclear ribonucleoprotein SNP1 and similar proteins; cd21615" /db_xref="CDD:410194" Site order(97,99..100,110,113..116,137,139..142,148..150,152, 179,182,184..188,194,196..198) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:410194" CDS 1..300 /gene="SNP1" /locus_tag="YIL061C" /coded_by="NM_001179411.1:1..903" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:physical interaction:GO:0000243 commitment complex [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0003729 mRNA binding [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0030619 U1 snRNA binding [PMID:1387202]" /note="Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1-70K, which has been linked to several types of autoimmune and neurodegenerative diseases" /db_xref="GeneID:854749" /db_xref="SGD:S000001323" ORIGIN 1 mnynlskypd dvsrlfkprp plsykrptdy pyakrqtnpn itgvanllst slkhymeefp 61 egspnnhlqr yediklskik naqlldrrlq nwnpnvdphi kdtdpyrtif igrlpydlde 121 ielqkyfvkf geiekirivk dkitqkskgy afivfkdpis skmafkeigv hrgiqikdri 181 civdiergrt vkyfkprrlg gglggrgysn rdsrlpgrfa sastsnpaer nyaprlprre 241 tsssaysadr ygsstldary rgnrpllsaa tptaavtsvy ksrnsrtres qpapkeapdy // LOCUS NP_012204 144 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL060W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012204 VERSION NP_012204.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179410.3 REFERENCE 1 (residues 1 to 144) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 144) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 144) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 144) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08490. On Jul 30, 2012 this sequence version replaced NP_012204.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..144 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..144 /product="uncharacterized protein" /calculated_mol_wt="15542" CDS 1..144 /locus_tag="YIL060W" /coded_by="NM_001179410.3:1..435" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24360837]" /note="Mitochondrial hypothetical protein; required for respiratory growth; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene" /db_xref="GeneID:854750" /db_xref="SGD:S000001322" ORIGIN 1 mmiiifielc riadsllwip kssrrtsstf yipniiallk mesqqlsqns ptlhihtcgs 61 kigtlflrft kvaigtsliv gagvamevsv plppqplysr sevpsvelcg ivaicrspps 121 vyptcrpisl skkivsglvr tnss // LOCUS NP_001418069 121 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL059C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001418069 VERSION NP_001418069.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001431140.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DBA54440. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..121 /product="uncharacterized protein" /calculated_mol_wt="12899" CDS 1..121 /locus_tag="YIL059C" /coded_by="NM_001431140.1:1..366" /note="hypothetical protein; has predicted signal peptide cleavage site in non-enzymatic end; located adjacent and on opposite strand to a Ty2 LTR, suggesting horizontal transfer; partially overlaps uncharacterized ORF YIL060W" /db_xref="GeneID:854752" /db_xref="SGD:S000001321" ORIGIN 1 mnfstvfqai iavlglttvt alaefdfdvg yeefvrtnpd tiflesdigl hvgytegger 61 qiatiphnst lgtslreysg cggngtetsi atpaptmsev piatfvkrrk svpillpqvc 121 m // LOCUS NP_012207 164 aa linear PLN 30-JUN-2025 DEFINITION Rgi2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012207 VERSION NP_012207.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179407.3 REFERENCE 1 (residues 1 to 164) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 164) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 164) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 164) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08491. On Jul 30, 2012 this sequence version replaced NP_012207.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..164 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..164 /product="Rgi2p" /calculated_mol_wt="19098" Region <24..159 /region_name="RGI1" /note="Respiratory growth induced protein 1; pfam10843" /db_xref="CDD:371266" CDS 1..164 /gene="RGI2" /locus_tag="YIL057C" /coded_by="NM_001179407.3:1..495" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006112 energy reserve metabolic process [PMID:20567505]" /note="hypothetical protein; involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose; RGI2 has a paralog, RGI1, that arose from the whole genome duplication" /db_xref="GeneID:854753" /db_xref="SGD:S000001319" ORIGIN 1 mtkkdkkakg pkmstittks geslkvfedl hdfetylkge tedqefdhvh cqlkyyppfv 61 lhdahddpek iketanshsk kfvrhlhqhv ekhllkdikt ainkpelkfh dkkkqesfdr 121 ivwnygeete lnakkfkvsv evvckhdgam vdvdyktepl qpli // LOCUS NP_012208 640 aa linear PLN 30-JUN-2025 DEFINITION Vhr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012208 VERSION NP_012208.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179406.1 REFERENCE 1 (residues 1 to 640) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 640) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 640) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 640) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08492. Method: conceptual translation. FEATURES Location/Qualifiers source 1..640 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..640 /product="Vhr1p" /calculated_mol_wt="71290" Region 16..97 /region_name="Vhr1" /note="Transcription factor Vhr1; pfam04001" /db_xref="CDD:397898" CDS 1..640 /gene="VHR1" /locus_tag="YIL056W" /coded_by="NM_001179406.1:1..1923" /experiment="EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:16533810]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:21278159]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16533810|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:21278159]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:21278159|PMID:16533810]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16533810]" /experiment="EXISTENCE:mutant phenotype:GO:1990383 cellular response to biotin starvation [PMID:16533810|PMID:21278159]" /note="Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication" /db_xref="GeneID:854755" /db_xref="SGD:S000001318" ORIGIN 1 mngpptftqy rinkfsgnga thkirellnf ndekkwkqfs srrlelidkf qlsqykaseq 61 dqnikqiati lrtefgypvs cskefeklvt aavqsvrrnr krskkryals iangsggnvn 121 nsissnstsd deispsiyqr snsdflpssn yaadfqfsnk fqplmshqsh ngtifptvgt 181 qndsspsvts tqqkyndivt mlvhdlvtnv vplseqalkd pytgpnlshf atsslsqqpn 241 ittnipidst vpfflrekll lqiqrsrtcq disqaagsid iyanleilge msirmsiafv 301 ierffsnlvs ssmkyitakt cspenlalls qrlfgaatrh nlshfpaaqv qlrllylvig 361 givkdfgfdp tlyplseiih hivmvqypla sscaseppss spnkrvkrsp pvvssdvmln 421 nnntlsnrat llttlpmkpq sankdvnrrv iirfndreqa ftfhqlsngp ptvsevlenc 481 knlfniinkn knfgifhndn llndeslakl fdsfstseih lvikdistip lqdakipvpi 541 tlpkmscige npsmpsiplv pqekddpkks sltafdniln riskspmnee nsnttlntgt 601 stsntnnndh nesvpapyvt knknsfqngn lpqpvfqpll // LOCUS NP_012209 627 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL055C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012209 VERSION NP_012209.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179405.1 REFERENCE 1 (residues 1 to 627) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 627) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 627) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 627) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08493. Method: conceptual translation. FEATURES Location/Qualifiers source 1..627 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..627 /product="uncharacterized protein" /calculated_mol_wt="70603" CDS 1..627 /locus_tag="YIL055C" /coded_by="NM_001179405.1:1..1884" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24390141]" /note="hypothetical protein" /db_xref="GeneID:854756" /db_xref="SGD:S000001317" ORIGIN 1 mtlephysak saasasafva rsatesstas tkaaprkkty sqsngipiri dnlppgktwa 61 qvkyliggii yhtnilqvkm lppmtsmvpp fitfqscivi lknsidnesl enllltlnty 121 qwdyhdlfvy llpytndsps lrypeisdsn ndvrsapdet krsispryas hvssvtpqpp 181 sastppsqff sfspevslrk nenitplptp vpvpvgvppl appphgpfst smlpmlgapp 241 gtvpnmqmpy qttlpsptaa ataggplasp thyprrrhfy hqnqsqfqky mhnsprnpdt 301 gtgprlsqqh hlslrnnkin psyneisaly nlnmasnsnn ngnipttstn gddralqakn 361 ggtitpsqtq inhkrlkhif neksfrkqmt nrgmwqlkii nfppyipief leklsesdfn 421 elmnqekftv ieikekgqle kfgrlrwtvl kdfiklkcpk llrlqerqfl qqqneaslln 481 esmdalkise nentngsann stytnggprt sinntrefyv gvyedheeat llrfelpede 541 leefnrnlpt tfaqsgnvsd segdskakyf kvstivynai vgfhdkelsd ltfeslqdqe 601 yslgykihvm elppfdedef enqrqqf // LOCUS NP_001257680 105 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL054W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257680 VERSION NP_001257680.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270751.1 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35118. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..105 /product="uncharacterized protein" /calculated_mol_wt="11914" CDS 1..105 /locus_tag="YIL054W" /coded_by="NM_001270751.1:1..318" /note="hypothetical protein; expressed at both mRNA and protein levels" /db_xref="GeneID:854757" /db_xref="SGD:S000001316" ORIGIN 1 mapkaffvcl pwvlprhali vrqagnpyhf laytnprapg klqdshcpvf fmgiiiitii 61 tvtlaiiiin iifltlfddg mcfycslltf sfvsfnfdhf dhfdl // LOCUS NP_012211 250 aa linear PLN 30-JUN-2025 DEFINITION glycerol-1-phosphatase GPP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012211 VERSION NP_012211.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179403.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08494. On Feb 6, 2006 this sequence version replaced NP_012211.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..250 /product="glycerol-1-phosphatase GPP1" /EC_number="3.1.3.21" /calculated_mol_wt="27816" Region 14..227 /region_name="HAD_ScGPP-like" /note="subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p); cd07527" /db_xref="CDD:319829" Site order(18..22,54..55,115..117,147,178..179,182..183) /site_type="active" /db_xref="CDD:319829" CDS 1..250 /gene="GPP1" /locus_tag="YIL053W" /gene_synonym="RHR2" /coded_by="NM_001179403.1:1..753" /experiment="EXISTENCE:direct assay:GO:0000121 sn-glycerol 1-phosphatase activity [PMID:8662716]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:27385335]" /experiment="EXISTENCE:mutant phenotype:GO:0006114 glycerol biosynthetic process [PMID:11058591]" /note="Constitutively expressed DL-glycerol-3-phosphate phosphatase; also known as glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; GPP1 has a paralog, GPP2, that arose from the whole genome duplication" /db_xref="GeneID:854758" /db_xref="SGD:S000001315" ORIGIN 1 mplttkplsl kinaalfdvd gtiiisqpai aafwrdfgkd kpyfdaehvi hishgwrtyd 61 aiakfapdfa deeyvnkleg eipekygehs ievpgavklc nalnalpkek wavatsgtrd 121 makkwfdilk ikrpeyfita ndvkqgkphp epylkgrngl gfpineqdps kskvvvfeda 181 pagiaagkaa gckivgiatt fdldflkekg cdiivknhes irvgeynaet develifddy 241 lyakddllkw // LOCUS NP_012212 121 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL34 RPL34B [Saccharomyces cerevisiae S288C]. ACCESSION NP_012212 VERSION NP_012212.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179402.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08495. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..121 /product="60S ribosomal protein eL34 RPL34B" /calculated_mol_wt="13510" Region 1..>108 /region_name="PTZ00074" /note="60S ribosomal protein L34; Provisional" /db_xref="CDD:185429" CDS 1..121 /gene="RPL34B" /locus_tag="YIL052C" /coded_by="NM_001179402.1:1..366" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication" /db_xref="GeneID:854759" /db_xref="SGD:S000001314" ORIGIN 1 maqrvtfrrr npyntrsnki kvvktpggil raqhvkklat rpkcgdcgsa lqgistlrpr 61 qyatvskthk tvsrayggsr cancvkeriv raflieeqki vkkvvkeqte aakksekksk 121 k // LOCUS NP_012213 145 aa linear PLN 30-JUN-2025 DEFINITION isoleucine biosynthesis protein MMF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012213 VERSION NP_012213.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179401.3 REFERENCE 1 (residues 1 to 145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 145) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08496. On Jul 30, 2012 this sequence version replaced NP_012213.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..145 /product="isoleucine biosynthesis protein MMF1" /calculated_mol_wt="15777" Region 21..143 /region_name="TIGR00004" /note="reactive intermediate/imine deaminase" /db_xref="CDD:129116" Site order(36..37,40,42,45,47,49..50,89,91..92,94,96,107,110, 119..126,136,138,140) /site_type="other" /note="homotrimer interaction site [polypeptide binding]" /db_xref="CDD:100004" Site order(36,103,107,121,136) /site_type="active" /note="putative active site [active]" /db_xref="CDD:100004" CDS 1..145 /gene="MMF1" /locus_tag="YIL051C" /gene_synonym="IBM1" /coded_by="NM_001179401.3:1..438" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11003673]" /experiment="EXISTENCE:genetic interaction:GO:0032543 mitochondrial translation [PMID:15164357]" /experiment="EXISTENCE:mutant phenotype:GO:0009097 isoleucine biosynthetic process [PMID:11442631]" /note="Mitochondrial protein required for transamination of isoleucine; but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; induction of expression in response to stress is mediated by a Hog1p-regulated antisense RNA and gene looping; interacts genetically with mitochondrial ribosomal protein genes; MMF1 has a paralog, HMF1, that arose from the whole genome duplication" /db_xref="GeneID:854760" /db_xref="SGD:S000001313" ORIGIN 1 mflrnsvlrt apvlrrgitt ltpvstklap paaasysqam kannfvyvsg qipytpdnkp 61 vqgsisekae qvfqnvknil aesnssldni vkvnvfladm knfaefnsvy akhfhthkpa 121 rscvgvaslp lnvdlemevi avekn // LOCUS NP_012214 285 aa linear PLN 30-JUN-2025 DEFINITION Pcl7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012214 VERSION NP_012214.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179400.3 REFERENCE 1 (residues 1 to 285) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 285) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 285) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 285) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08497. On Jul 30, 2012 this sequence version replaced NP_012214.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..285 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..285 /product="Pcl7p" /calculated_mol_wt="31906" Region 108..264 /region_name="Cyclin" /note="pfam08613" /db_xref="CDD:400780" Site order(174,176,226..232,234..236,250,253..254,257..258, 261..267) /site_type="other" /note="CDK interface [polypeptide binding]" /db_xref="CDD:410261" CDS 1..285 /gene="PCL7" /locus_tag="YIL050W" /coded_by="NM_001179400.3:1..858" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16611745]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:12407105]" /experiment="EXISTENCE:genetic interaction:GO:0005979 regulation of glycogen biosynthetic process [PMID:11602261]" /experiment="EXISTENCE:genetic interaction:GO:0005981 regulation of glycogen catabolic process [PMID:11602261]" /experiment="EXISTENCE:mutant phenotype:GO:0031647 regulation of protein stability [PMID:16611745]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:16611745]" /note="Pho85p cyclin of the Pho80p subfamily; forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated; PCL7 has a paralog, PCL6, that arose from the whole genome duplication" /db_xref="GeneID:854761" /db_xref="SGD:S000001312" ORIGIN 1 melsspskkt ttspinipgg nrdnliigph shsfktdpfs snnssllski stnpslespf 61 sskslldcsp vqavkksles eakthsldee tneqtdvkil niadfptdel ilmisallnr 121 iitandettd vsqqvsdete delltpilaf ygknvpeiav vqyleriqky cpttndifls 181 llvyfdrisk nyghsserng cakqlfvmds gnihrllitg vtictkflsd ffysnsryak 241 vggislqeln hlelqflilc dfkllvsvee mqkyanllyk fwndq // LOCUS NP_012215 253 aa linear PLN 30-JUN-2025 DEFINITION putative polyprenol reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012215 VERSION NP_012215.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179399.1 REFERENCE 1 (residues 1 to 253) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 253) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 253) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 253) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08498. Method: conceptual translation. FEATURES Location/Qualifiers source 1..253 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..253 /product="putative polyprenol reductase" /EC_number="1.3.1.94" /calculated_mol_wt="30175" Region 60..252 /region_name="ICMT" /note="Isoprenylcysteine carboxyl methyltransferase (ICMT) family; cl21511" /db_xref="CDD:473892" CDS 1..253 /gene="DFG10" /locus_tag="YIL049W" /coded_by="NM_001179399.1:1..762" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:20637498]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]" /experiment="EXISTENCE:mutant phenotype:GO:0043048 dolichyl monophosphate biosynthetic process [PMID:20637498]" /note="Probable polyprenol reductase; catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human homolog SRD5A3 confer CDG (Congenital Disorders of Glycosylation); human SRD5A3 can complement yeast null mutant" /db_xref="GeneID:854762" /db_xref="SGD:S000001311" ORIGIN 1 myfdeeqllk ytiyayrlsf fvgicslfia ksclpeflqy gktyrpkens kyssilerik 61 kftvpkayfs hfyylatfls lvtlyfypkf pivwiifghs lrrlyetlyv lhytsnsrmn 121 wshylvgiwf ysvlllilni slyknsipnt lnmnafiifc iaswdqyknh vilanlvkys 181 lptgrlfrlv ccphyldeii iystllpyeq efyltlvwvi tsltisalet knyyrhkfkd 241 nhvapyaiip fii // LOCUS NP_012216 1151 aa linear PLN 30-JUN-2025 DEFINITION aminophospholipid-translocating P4-type ATPase NEO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012216 VERSION NP_012216.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179398.1 REFERENCE 1 (residues 1 to 1151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1151) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08499. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1151 /product="aminophospholipid-translocating P4-type ATPase NEO1" /EC_number="7.6.2.1" /calculated_mol_wt="130087" Region 172..1067 /region_name="P-type_ATPase_APLT_Neo1-like" /note="Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; cd07541" /db_xref="CDD:319841" Site order(503..505,640,664..666,726,774..776,856,859,862,882, 885) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:319841" Region 574..670 /region_name="Cation_ATPase" /note="Cation transport ATPase (P-type); pfam13246" /db_xref="CDD:463817" CDS 1..1151 /gene="NEO1" /locus_tag="YIL048W" /coded_by="NM_001179398.1:1..3456" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12960419]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:15314152]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:30981741]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15314152]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:30981741]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:27235400]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:12960419]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:15314152]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:15314152]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:27235400]" /note="Phospholipid translocase (flippase); involved in generating phospholipid asymmetry in plasma membrane; involved in endocytosis, vacuolar biogenesis and Golgi-to-ER vesicle-mediated transport; localizes to endosomes and Golgi apparatus; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:854763" /db_xref="SGD:S000001310" ORIGIN 1 mpnppsfksh kqnlfnsnnn qhansvdsfd lhlddsfdaa ldslqinnnp eplskhntvg 61 dresfemrtv ddldnfsnhs sdshrkssnt dthplmydnr lsqddnfkft niassppsss 121 nnifskalsy lkvsntknws kfgspielsd qhiereihpd ttpvydrnry vsnelsnaky 181 navtfvptll yeqfkffynl yflvvalsqa vpalrigyls syivplafvl tvtmakeaid 241 diqrrrrdre snnelyhvit rnrsipskdl kvgdlikvhk gdripadlvl lqssepsges 301 fiktdqldge tdwklrvacp ltqnlsendl inrisitasa peksihkflg kvtykdstsn 361 plsvdntlwa ntvlassgfc iacvvytgrd trqamnttta kvktgllele insiskilca 421 cvfalsillv afagfhnddw yidilrylil fstiipvslr vnldlaksvy ahqiehdkti 481 petivrtsti pedlgrieyl lsdktgtltq ndmqlkkihl gtvsytsetl divsdyvqsl 541 vsskndslnn skvalsttrk dmsfrvrdmi ltlaichnvt ptfeddelty qaaspdeiai 601 vkftesvgls lfkrdrhsis llhehsgktl nyeilqvfpf nsdskrmgii vrdeqldeyw 661 fmqkgadtvm skivesndwl eeetgnmare glrtlvigrk klnkkiyeqf qkeyndasls 721 mlnrdqqmsq vitkylehdl ellgltgved klqkdvkssi ellrnagiki wmltgdkvet 781 arcvsisakl isrgqyvhti tkvtrpegaf nqleylkinr nacllidges lgmflkhyeq 841 effdvvvhlp tviacrctpq qkadvalvir kmtgkrvcci gdggndvsmi qcadvgvgiv 901 gkegkqasla adfsitqfch ltelllwhgr nsykrsakla qfvmhrglii aicqavysic 961 slfepialyq gwlmvgyatc ytmapvfslt ldhdieeslt kiypelykel tegkslsykt 1021 ffvwvllslf qgsviqlfsq aftslldtdf trmvaisfta lvvnelimva leiytwnktm 1081 lvteiatllf yivsvpflgd yfdlgymttv nyyagllvil lisifpvwta kaiyrrlhpp 1141 syakvqefat p // LOCUS NP_012217 902 aa linear PLN 30-JUN-2025 DEFINITION Syg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012217 VERSION NP_012217.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179397.3 REFERENCE 1 (residues 1 to 902) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 902) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 902) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 902) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 902) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 902) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 902) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08500. On Jul 30, 2012 this sequence version replaced NP_012217.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..902 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..902 /product="Syg1p" /calculated_mol_wt="104087" Region 1..310 /region_name="COG5408" /note="SPX domain-containing protein [Signal transduction mechanisms]" /db_xref="CDD:227695" Region 402..803 /region_name="COG5409" /note="EXS domain-containing protein [Signal transduction mechanisms]" /db_xref="CDD:227696" CDS 1..902 /gene="SYG1" /locus_tag="YIL047C" /coded_by="NM_001179397.3:1..2709" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:7592711]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:7592711]" /note="Plasma membrane hypothetical protein; targeted to vacuole via AP-3 pathway; truncation and overexpression suppresses lethality of G-alpha protein deficiency" /db_xref="GeneID:854764" /db_xref="SGD:S000001309" ORIGIN 1 mkfadhltes aipewrdkyi dykvgkkklr rykekldaee eqsssyrswm psvsvyqtaf 61 qqrepgksrs dgdyrsgpaf kkdysalqre fvadfiedwl isfqlskcne fylwllkecd 121 kkfevlqsql hyyslqknye rdnlnrsssn vdmstslyaa glagrsdsrv nsidsdsrsv 181 mygsmpctke akkprlslla ycqkvlkdnr llpswpkrgf sllqdlrqda ssrgretfaf 241 gasfletmtt tqarnllsna iieyylylql vksfrdinvt gfrkmvkkfd ktchtreltt 301 fmsyarthyt lfkhadanvq lvaqkmqqit ssqptptsel ssaqrdkepi twletqitew 361 fttaltnspk drkhnthklk kltiqysise qmvhrnnrsi vqmlvvglgi gvsmtlityt 421 lylgisseet sfthkilfpl wggwymvlli aflflvncfi whrtginyrf imlgeiqskn 481 gtqffnndfa tskiplklyf ltffivpcav csmlsfalek ltplgflyig ivsflflcps 541 glipywdkvv htrkwlvvtl irlmmsgffp vefgdfflgd iicsltysia diamffcvys 601 htpnnlcgss hsramgvlsc lpsywrfmqc lrrfadsgdw fphllnaaky tlgiaynatl 661 cayrlsdrse qrrtpfivca tlnsiltsaw dlvmdwsfah nttsynwllr ddlylagkkn 721 wengsysfsr klvyyfamiw dilirfewiv yaiapqtiqq savtsfilal levlrrfvwi 781 ifrvenehva nvhlfrvtgd aplpypiaqv gddsmdssdl gskafsslnd ipitpshdnn 841 phsfaepmpa yrgtfrrrss vfenisrsip wahatdfqrp tvntvddrsp etdseseves 901 im // LOCUS NP_878097 54 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL046W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878097 VERSION NP_878097.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184654.1 REFERENCE 1 (residues 1 to 54) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 54) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 54) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 54) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08501. Method: conceptual translation. FEATURES Location/Qualifiers source 1..54 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..54 /product="uncharacterized protein" /calculated_mol_wt="6177" CDS 1..54 /locus_tag="YIL046W-A" /coded_by="NM_001184654.1:1..165" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466492" /db_xref="SGD:S000028836" ORIGIN 1 mmcvcipkkk lmdwrvyyiy syvvclymcg sdcacicvla cvvqcvcfnv emrl // LOCUS NP_012218 640 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-binding SDF ubiquitin ligase complex subunit MET30 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012218 VERSION NP_012218.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179396.1 REFERENCE 1 (residues 1 to 640) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 640) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 640) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 640) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08502. Method: conceptual translation. FEATURES Location/Qualifiers source 1..640 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..640 /product="ubiquitin-binding SDF ubiquitin ligase complex subunit MET30" /calculated_mol_wt="72705" Region 183..228 /region_name="F-box_SpPof1-like" /note="F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; cd22147" /db_xref="CDD:438918" Site order(187,191,194..195,198..199,203,205..206,210..212,214) /site_type="other" /note="putative Skp1 binding site [polypeptide binding]" /db_xref="CDD:438918" Region 295..590 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(301,317,321,327..328,340..341,357,361,367..368, 380..381,396,401,407..408,420,437,442,448..449,461..462, 527,531,537..538,550..551,566,571,577..578,590) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 305..340 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 346..380 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 385..418 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 425..460 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 488..549 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..640 /gene="MET30" /locus_tag="YIL046W" /gene_synonym="ZRG11" /coded_by="NM_001179396.1:1..1923" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10637232]" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:9716410]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:direct assay:GO:0043224 nuclear SCF ubiquitin ligase complex [PMID:10637232]" /experiment="EXISTENCE:direct assay:GO:0046685 response to arsenic-containing substance [PMID:15689486]" /experiment="EXISTENCE:direct assay:GO:0046686 response to cadmium ion [PMID:15689486]" /experiment="EXISTENCE:genetic interaction:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:9716410]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:15870262]" /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:9716410]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15870262]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:39378345]" /experiment="EXISTENCE:mutant phenotype:GO:0140299 molecular sensor activity [PMID:39378345]" /note="Nuclear F-box protein and subunit of the SCF-Met30 Ub-ligase complex; controls the cell cycle, sulfur metabolism, and methionine biosynthesis as part of the SCF-Met30 Ub-ligase complex; sulfide-sensor that represses the activity of Met4p in response to sulfur abundance; involved in the turnover of Cdk-inhibitory kinase Swe1p; Cdc48p catalyzes dissociation of Met30p from the SCF complex in response to cadmium stress; contains a WD40 repeat region with cysteines that sense sulfur availability" /db_xref="GeneID:854765" /db_xref="SGD:S000001308" ORIGIN 1 mrrerqrmms fedkdkddld nsnsnnssem tdtammpplk rllitgssdd laqgssgkkk 61 mtmatrspss spdlatndsg trvqplpeyn ftkfcyrhnp diqfspthta cykqdlkrtq 121 einaniaklp lqeqsdihhi iskysnsndk irklildgil stscfpqlsy isslvthmik 181 idfisilpqe lslkilsyld cqslcnatrv crkwqkladd drvwyhmceq hidrkcpncg 241 wglpllhmkr ariqqnstgs ssnadiqtqt trpwkviyre rfkvesnwrk ghcriqefkg 301 hmdgvltlqf nyrllftgsy dstigiwdlf tgklirrlsg hsdgvktlyf ddrklitgsl 361 dktirvwnyi tgecistyrg hsdsvlsvds yqkvivsgsa dktvkvwhve srtcytlrgh 421 tewvncvklh pksfscfscs ddttirmwdi rtnsclkvfr ghvgqvqkii pltikdvenl 481 atdntsdgss pqddptmtdg adesdtpsne qetvldenip ypthllscgl dntiklwdvk 541 tgkcirtqfg hvegvwdiaa dnfriisgsh dgsikvwdlq sgkcmhtfng rrlqretqht 601 qtqslgdkva piacvcigds ecfsgdefgc vkmykfdlnd // LOCUS NP_012219 538 aa linear PLN 30-JUN-2025 DEFINITION putative protein phosphatase regulator PIG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012219 VERSION NP_012219.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179395.3 REFERENCE 1 (residues 1 to 538) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 538) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 538) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 538) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08503. On Jul 30, 2012 this sequence version replaced NP_012219.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..538 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..538 /product="putative protein phosphatase regulator PIG2" /calculated_mol_wt="61807" Region 388..507 /region_name="CBM_21" /note="Carbohydrate/starch-binding module (family 21); pfam03370" /db_xref="CDD:427265" CDS 1..538 /gene="PIG2" /locus_tag="YIL045W" /coded_by="NM_001179395.3:1..1617" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:physical interaction:GO:0005979 regulation of glycogen biosynthetic process [PMID:9046081]" /note="Putative type-1 protein phosphatase targeting subunit; tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase; PIG2 has a paralog, GIP2, that arose from the whole genome duplication" /db_xref="GeneID:854766" /db_xref="SGD:S000001307" ORIGIN 1 matttqpqni lmdeplnlpn nsahnnnygn inanirtfag msmhmhparl nsleflhkpr 61 rlsnvklhrl pqdelqrntd mnkgmyfngk qvhahhpfin sganfnahhq dvsklgeeed 121 eisplshdnf qyeseengnp sppiykksge lvksslkrrs kslpitpksi fnktgskskh 181 vnldhvdtrl lqrsksvhfd rvlpiklfne nekpidvgkq mvqqdvlnfk hkpltrlsal 241 nggsdsvpie dllsennqne ygdtwlqnpk gvflfgtnsn nrrnkkkkfk lsdddsdien 301 dndsddainr lvrqqdkdqa hlahglknll inddddylet rtnsaksgan lfignskriv 361 glynknfpil sdrnrkslkl niflnlsrgr pvflqeitll tgfhnmviig kvfvkniyfd 421 kkiivrytwd awrtfhesec vyfsnangil pgsnmdifkf siddihnpnd kdsnisqlef 481 ciqyltwgvd rsrkeywdnn dsanykidvv tnetrtgptt dvndnyemkh slfrnpfh // LOCUS NP_012220 298 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein AGE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012220 VERSION NP_012220.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179394.3 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08504. On Jul 30, 2012 this sequence version replaced NP_012220.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..298 /product="GTPase-activating protein AGE2" /calculated_mol_wt="32507" Region 1..298 /region_name="COG5347" /note="GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]" /db_xref="CDD:227651" CDS 1..298 /gene="AGE2" /locus_tag="YIL044C" /gene_synonym="SAT2" /coded_by="NM_001179394.3:1..897" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:12627398]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9677411]" /experiment="EXISTENCE:genetic interaction:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:9677411]" /note="ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector; involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif" /db_xref="GeneID:854767" /db_xref="SGD:S000001306" ORIGIN 1 mstsvpvkka lsallrdpgn shcadckaql hprwaswslg vficikcagi hrslgthisk 61 vksvdldtwk eehlvkliqf knnlransyy eatladelkq rkitdtsslq nfiknkyeyk 121 kwigdlssie glndstepvl hkpsanhslp asnarldqss nslqktqtqp pshllstsrs 181 ntsllnlqvs slskttsnts vtssatsiga antktgnrvg efgqrndlkk silslyskps 241 aqtqsqnsff tsttpqpcnt pspfvntgit atnnnsmnsn sssnislddn elfknvws // LOCUS NP_012221 284 aa linear PLN 30-JUN-2025 DEFINITION cytochrome-b5 reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012221 VERSION NP_012221.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179393.1 REFERENCE 1 (residues 1 to 284) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 284) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 284) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 284) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08505. On Feb 6, 2006 this sequence version replaced NP_012221.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..284 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..284 /product="cytochrome-b5 reductase" /EC_number="1.6.2.2" /calculated_mol_wt="31363" Region 43..284 /region_name="cyt_b5_reduct_like" /note="Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a...; cd06183" /db_xref="CDD:99780" Site order(76,90..93,108..110,112,114..118,156,159..160,284) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99780" Site order(90,92..93) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99780" Site order(110,112,156..157,183..185,214,227,251..255) /site_type="other" /note="NAD binding pocket [chemical binding]" /db_xref="CDD:99780" Site order(115,118,121,127,135,137) /site_type="other" /note="phosphate binding motif [ion binding]" /db_xref="CDD:99780" Site order(151,155..158,160) /site_type="other" /note="beta-alpha-beta structure motif" /db_xref="CDD:99780" CDS 1..284 /gene="CBR1" /locus_tag="YIL043C" /gene_synonym="CBR5" /coded_by="NM_001179393.1:1..855" /experiment="EXISTENCE:direct assay:GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H [PMID:27694803|PMID:14930]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:27694803]" /note="Cytochrome b reductase and NADH-dependent reductase for Dph3p; required for diphthamide synthesis and tRNA wobble uridine modification; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia" /db_xref="GeneID:854768" /db_xref="SGD:S000001305" ORIGIN 1 maidaqklvv vivivvvpll fkfiigpktk pvldpkrndf qsfplvekti lthntsmykf 61 glphaddvlg lpigqhivik aningkditr sytptsldgd tkgnfellvk syptgnvskm 121 igelkigdsi qikgprgnyh yerncrshlg miaggtgiap myqimkaiam dphdttkvsl 181 vfgnvheedi llkkelealv amkpsqfkiv yyldspdred wtggvgyitk dvikehlpaa 241 tmdnvqilic gppamvasvr rstvdlgfrr skplskmedq vfvf // LOCUS NP_012222 394 aa linear PLN 30-JUN-2025 DEFINITION protein kinase PKP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012222 VERSION NP_012222.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179392.1 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08506. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..394 /product="protein kinase PKP1" /EC_number="2.7.11.2" /calculated_mol_wt="45313" Region 55..212 /region_name="BCDHK_Adom3" /note="Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase; pfam10436" /db_xref="CDD:463093" Region 216..383 /region_name="HATPase_PDK-like" /note="Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; cd16929" /db_xref="CDD:340406" Site order(247,289,291,294..297,299..301,305,310..312,368, 370..374,377,381) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:340406" Site order(267,271..272,274..275,302,304,306,308..309,317, 346..353,369,371,375..376,378) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:340406" Site order(318,352) /site_type="other" /note="ATP-lid" /db_xref="CDD:340406" CDS 1..394 /gene="PKP1" /locus_tag="YIL042C" /coded_by="NM_001179392.1:1..1185" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:17918780]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:16643908|PMID:17918780]" /experiment="EXISTENCE:mutant phenotype:GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity [PMID:18180296|PMID:16643908]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:16643908]" /experiment="EXISTENCE:mutant phenotype:GO:1901524 regulation of mitophagy [PMID:31548421]" /note="Mitochondrial protein kinase; involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p" /db_xref="GeneID:854769" /db_xref="SGD:S000001304" ORIGIN 1 mwkimrswkc ggmrwahrqr pshellsqls fdqhykirsn ielliqdyas kpiaplnyey 61 flqyrppltk keeymltikt inlllsltck rlnaiqrlpy navinphier tnslylkslq 121 tllsiaypye lhnppkiqak ftellddhed aivvlakglq eiqscypkfq isqflnfhlk 181 eritmkllvt hylslmaqnk gdtnkrmigi lhrdlpiaql ikhvsdyvnd icfvkfntqr 241 tpvlihppsq ditftcippi leyimtevfk nafeaqialg kehmpieinl lkpdddelyl 301 rirdhgggit pevealmfny systhtqqsa dsestdlpge qinnvsgmgf glpmcktyle 361 lfggkidvqs llgwgtdvyi klkgpsktal lskk // LOCUS NP_012223 326 aa linear PLN 30-JUN-2025 DEFINITION Gvp36p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012223 VERSION NP_012223.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179391.3 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08507. On Jul 30, 2012 this sequence version replaced NP_012223.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..326 /product="Gvp36p" /calculated_mol_wt="36539" Region 27..299 /region_name="BAR_2" /note="Bin/amphiphysin/Rvs domain for vesicular trafficking; pfam10455" /db_xref="CDD:402196" Site order(94,97..98,103,105..106,109..110,112..113,130..131, 133..134,137..138,140..141,144,167,170..171,260,263..264, 266,269,272..273,275..276,279..280,283..284,286..287, 290..291,293..294) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153284" CDS 1..326 /gene="GVP36" /locus_tag="YIL041W" /coded_by="NM_001179391.3:1..981" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:18156177]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:18156177]" /experiment="EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:18156177]" /note="BAR domain protein that localizes to early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis" /db_xref="GeneID:854770" /db_xref="SGD:S000001303" ORIGIN 1 msfnafassl skklqeists vsektqelps laqstqrmvq erlgqvtdis qlpreytele 61 dkvdtikliy nhflgvtaiy engsydypky inesvnefsr svaskltelt hatsaseaqn 121 ilvapgpike pktlnyalsk valnssecln kmfpteeqpl asallqfsdv qakiaqariq 181 qdtliqtkfn knlrerlsfe igkadkcrkd vhsmrlrydv artnlannkk pekeaslrvq 241 metledqfaq vtedatvclq evishanfse dlkelakaqa eyfetsaglm keflsnsfae 301 epeakpevae eekpqtaism ndedda // LOCUS NP_012224 138 aa linear PLN 30-JUN-2025 DEFINITION Apq12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012224 VERSION NP_012224.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179390.1 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08508. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..138 /product="Apq12p" /calculated_mol_wt="16377" CDS 1..138 /gene="APQ12" /locus_tag="YIL040W" /coded_by="NM_001179390.1:1..417" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15273328|PMID:26432634]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26432634|PMID:14562095|PMID:15273328|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:17724120]" /experiment="EXISTENCE:genetic interaction:GO:0055088 lipid homeostasis [PMID:20016074|PMID:26432634]" /experiment="EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:20016074|PMID:17724120]" /experiment="EXISTENCE:mutant phenotype:GO:0055088 lipid homeostasis [PMID:20016074|PMID:26432634]" /note="Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism" /db_xref="GeneID:854771" /db_xref="SGD:S000001302" ORIGIN 1 mdatqpqyel svvtqclksa idviqwlipt itkfsqshpl vfqllfifft fyvfykllmn 61 fitlvkrfly ltlvvtcigi ymrgsqqflt vdllnfynfv msnryyafki ytlfinaler 121 eintvyhlaq mkmeqllk // LOCUS NP_012225 473 aa linear PLN 30-JUN-2025 DEFINITION Ted1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012225 VERSION NP_012225.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179389.1 REFERENCE 1 (residues 1 to 473) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 473) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 473) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 473) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08509. Method: conceptual translation. FEATURES Location/Qualifiers source 1..473 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..473 /product="Ted1p" /calculated_mol_wt="54797" Region 83..421 /region_name="MPP_Ted1" /note="Saccharomyces cerevisiae Ted1 and related proteins, metallophosphatase domain; cd08164" /db_xref="CDD:277371" Site order(87,89,133,233..234,315,379,381) /site_type="active" /note="putative active site [active]" /db_xref="CDD:277371" Site order(87,89,133,233,315,379,381) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:277371" CDS 1..473 /gene="TED1" /locus_tag="YIL039W" /coded_by="NM_001179389.1:1..1422" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17989219]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:17989219]" /note="GPI-glycan remodelase; conserved phosphoesterase domain-containing protein; acts together with Emp24p/Erv25p in cargo exit from the ER; functional ortholog of mammalian GPI-glycan remodelase PGAP5; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)" /db_xref="GeneID:854772" /db_xref="SGD:S000001301" ORIGIN 1 mlrcavkkfa yfatfltiva niyiytypsf hpeqcswncs nknaplqkdl tfvdkvknyf 61 sdvreqwhgs hasagndedi hilafgdpqi kgiwpktpyv srldtygndy ylghiydmmq 121 qrlkpqvvtv mgdlfssqwi gdsefhnrtk ryisrifkrd ptsienikqq nldekgqyka 181 nwpewgdrfn eildnvkene adnqelsfgf gyenihswnp dledfliini tgnhdvgysg 241 datyqhmtrf hdlfgkdnyw ieyetntthp wrivvlndll legpalqpef veatwiflnq 301 lnerkfngst vllthvpfyk reglcvdgpd tryypdahap esyksgllrs qnhlsesvsn 361 qvlnmifeng kpgiiltghd hegcetvynk kststweatk niesdvfvke itvksmmgef 421 ngntglvtgh fntdsmtwew tfslcpfaiq hvwwfakvsl lvtiftwssl lfv // LOCUS NP_012226 836 aa linear PLN 30-JUN-2025 DEFINITION CCR4-NOT core subunit NOT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012226 VERSION NP_012226.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179388.3 REFERENCE 1 (residues 1 to 836) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 836) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 836) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 836) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 836) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 836) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 836) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08510. On Jul 30, 2012 this sequence version replaced NP_012226.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..836 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..836 /product="CCR4-NOT core subunit NOT3" /calculated_mol_wt="94272" Region 2..230 /region_name="Not3" /note="Not1 N-terminal domain, CCR4-Not complex component; pfam04065" /db_xref="CDD:461155" Region <293..399 /region_name="PHA03247" /note="large tegument protein UL36; Provisional" /db_xref="CDD:223021" Region <695..782 /region_name="NOT2_3_5" /note="NOT2 / NOT3 / NOT5 family; pfam04153" /db_xref="CDD:461199" CDS 1..836 /gene="NOT3" /locus_tag="YIL038C" /coded_by="NM_001179388.3:1..2511" /experiment="EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:26952104]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16926149]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:26952104]" /experiment="EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:10490603]" /note="Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers" /db_xref="GeneID:854773" /db_xref="SGD:S000001300" ORIGIN 1 mahrklqqev drvfkkineg leifnsyyer hesctnnpsq kdklesdlkr evkklqrlre 61 qikswqsspd ikdkdslldy rrsveiamek ykavekaske kaysnislkk setldpqere 121 rrdiseylsq midelerqyd slqveidkll llnkkkktss ttndekkeqy krfqaryrwh 181 qqqmelalrl laneeldpqd vknvqddiny fvesnqdpdf vedetiydgl nlqsneaiah 241 evaqyfasqn aednntsdan eslqdiskls kkeqrklere akkaaklaak natgaaipva 301 gpsstpspvi pvadaskete rspssspihn atkpeeavkt siksprssad nllpslqksp 361 ssatpetptn vhthihqtpn gitgattlkp atlpakpage lkwavaasqa vekdrkvtsa 421 sstisntstk tpttaaattt ssnansrigs alntpklsts slslqpdntg asssaataaa 481 vlaagaaavh qnnqafyrnm ssshhplvsl atnpksehev attvnqngpe nttkkvmeqk 541 eeespeernk lqvptfgvfd ddfesdrdse tepeeeeqps tpkylsleqr eaktneikke 601 fvsdfetlll psgvqefims selynsqies kitykrsrdm ceisrlvevp qgvnppspld 661 afrstqqwdv mrcslrdiii gserlkedss siyakilenf rtlemfslfy nyyfaitple 721 reiaykilne rdwkvskdgt mwflrqgevk ffneicevgd ykifklddwt vidkinfrld 781 ysflqppvdt asevrdvsvd nnnvndqsnv tleqqkqeis hgkqllkqlk qgkisv // LOCUS NP_012227 656 aa linear PLN 30-JUN-2025 DEFINITION pheromone-regulated protein PRM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012227 VERSION NP_012227.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179387.3 REFERENCE 1 (residues 1 to 656) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 656) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 656) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 656) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08511. On Jul 30, 2012 this sequence version replaced NP_012227.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..656 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..656 /product="pheromone-regulated protein PRM2" /calculated_mol_wt="74890" CDS 1..656 /gene="PRM2" /locus_tag="YIL037C" /coded_by="NM_001179387.3:1..1971" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:17101777]" /note="Pheromone-regulated protein; predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion" /db_xref="GeneID:854774" /db_xref="SGD:S000001299" ORIGIN 1 mnnvhiikpl slpqrffsci fhplllifft sviltiwgsf sviditmakm shaqvkrndt 61 vstfasista tatatttatt tatmtavttq haiysansys lnktfidnti dqyfesklrs 121 iestvgtdmq ekfksytddi ldnkqklind qisletelik evlevnntif nelltksqli 181 ndtwneised amtidkdsis qmasnlllny smfdsifgny srklkslqnf ngtitdfstq 241 ldtsstlsln flrnstdwlq lkrnftanlq neisilsggs tevtsstsii krslktnsee 301 nsvlsavknh vfrkckrmti iftvmyfafv illmaieril fqlenqqvnl vmsqingltg 361 qtnftkynkv lkslittlnl stlypipyql tklinqkifk repekiddkk vkksklfycn 421 wwiisngahl wlfgflmlli hwqivtrltn fevpslptfh kragpslykr evwtdgnitt 481 tiegfindsv sllcenfqme vnekfitanl slqtdpnlkv qstdilnlwv ndtntqfeky 541 lnessqnwqg idlqvepllg sdsineflgq yflptyevtn tnssfaldiq kygiinrgin 601 itnasvaals slskrqikdk eqkqtyflht vykwgllavc ltilfhhmli fiilkl // LOCUS NP_012228 587 aa linear PLN 30-JUN-2025 DEFINITION Cst6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012228 VERSION NP_012228.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179386.1 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08512. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..587 /product="Cst6p" /calculated_mol_wt="65133" Region 427..484 /region_name="bZIP_ATF2" /note="Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain; cd14687" /db_xref="CDD:269835" Region 427..484 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269835" Site order(428,432,434..436,439,441..443,445..447) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269835" Site order(446,453..454,456..457,460..461,464,467..468,471, 474..475,477..478,481..482) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269835" CDS 1..587 /gene="CST6" /locus_tag="YIL036W" /gene_synonym="ACA2; SHF1" /coded_by="NM_001179386.1:1..1764" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10825197]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:27143390]" /experiment="EXISTENCE:direct assay:GO:0033554 cellular response to stress [PMID:27143390]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:10825197|PMID:27143390]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10825197]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20395639]" /experiment="EXISTENCE:mutant phenotype:GO:0071244 cellular response to carbon dioxide [PMID:22253597]" /experiment="EXISTENCE:mutant phenotype:GO:0071400 cellular response to oleic acid [PMID:20395639]" /note="Basic leucine zipper (bZIP) transcription factor from ATF/CREB family involved in stress-responsive regulatory network; mediates transcriptional activation of NCE103 in response to low CO2 levels; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication" /db_xref="GeneID:854775" /db_xref="SGD:S000001298" ORIGIN 1 mftgqeyhsv dsnsnkqkdn nkrgiddtsk ilnnkiphsv sdtsaaattt stmnnsalsr 61 sldptdinys tnmagvvdqi hdyttsnrns ltpqysiaag nvnshdrvvk psansnyqqa 121 aylrqqqqqd qrqqspsmkt eeesqlygdi lmnsgvvqdm hqnlathtnl sqlsstrksa 181 pndsttaptn asniantasv nkqmyfmnmn mnnnphalnd psiletlspf fqpfgvdvah 241 lpmtnppifq sslpgcdepi rrrrisisng qisqlgedie tlenlhntqp ppmpnfhnyn 301 glsqtrnvsn kpvfnqavpv ssipqynakk vinptkdsal gdqsviysks qqrnfvnaps 361 kntpaesisd legmttfapt tggenrgksa lreshsnpsf tpksqgshln laantqgnpi 421 pgttawkrar llernriaas kcrqrkkvaq lqlqkefnei kdenrillkk lnyyeklisk 481 fkkfskihlr eheklnkdsd nnvngtnssn knesmtvdsl kiieellmid sdvtevdkdt 541 gkiiaikhep ysqrfgsdtd dddidlkpve ggkdpdnqsl pnsekik // LOCUS NP_012229 372 aa linear PLN 30-JUN-2025 DEFINITION casein kinase 2 catalytic subunit CKA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012229 VERSION NP_012229.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179385.1 REFERENCE 1 (residues 1 to 372) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 372) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 372) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 372) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08513. Method: conceptual translation. FEATURES Location/Qualifiers source 1..372 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..372 /product="casein kinase 2 catalytic subunit CKA1" /EC_number="2.7.11.1" /calculated_mol_wt="44537" Region 21..363 /region_name="STKc_CK2_alpha" /note="Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; cd14132" /db_xref="CDD:271034" Site order(37,40..42,68,94,140,142..143,149) /site_type="other" /note="allosteric inhibitor binding site [chemical binding]" /db_xref="CDD:271034" Site order(37..38,40..43,51,55,142) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:271034" Site order(37..38,40..42,58,60,142) /site_type="other" /note="CK2 beta interface [polypeptide binding]" /db_xref="CDD:271034" Site order(46..50,54,67,93,108,134,152..155,159,161..162,195, 197,199..200,202,214,217,228,230..233,235,274) /site_type="active" /db_xref="CDD:271034" Site order(48..49,51..52,54,67,93,134,152..153,155,199..200,202, 213..214) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271034" Site order(108,161,195,197,217,228,230..233,235,274) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271034" Site order(213..223,228..235) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271034" CDS 1..372 /gene="CKA1" /locus_tag="YIL035C" /coded_by="NM_001179385.1:1..1119" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8226802]" /experiment="EXISTENCE:direct assay:GO:0005956 protein kinase CK2 complex [PMID:8135547]" /experiment="EXISTENCE:direct assay:GO:0006356 regulation of transcription by RNA polymerase I [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0006359 regulation of transcription by RNA polymerase III [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0006974 DNA damage response [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0034456 UTP-C complex [PMID:17515605]" /experiment="EXISTENCE:genetic interaction:GO:0007535 donor selection [PMID:22496671]" /note="Alpha catalytic subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; regulates Fkh1p-mediated donor preference during mating-type switching" /db_xref="GeneID:854776" /db_xref="SGD:S000001297" ORIGIN 1 mkcrvwsear vytninkqrt eeywdyentv idwstntkdy eienkvgrgk ysevfqgvkl 61 dskvkivikm lkpvkkkkik reikiltdls nekvppttlp fqkdqyytnq kedvlkfirp 121 yifdqphngh aniihlfdii kdpisktpal vfeyvdnvdf rilypkltdl eirfymfell 181 kaldychsmg imhrdvkphn vmidhknkkl rlidwglaef yhvnmeynvr vasrffkgpe 241 llvdyrmydy sldlwsfgtm lasmifkrep ffhgtsntdq lvkivkvlgt sdfekyllky 301 eitlprefyd mdqyirkpwh rfindgnkhl sgndeiidli dnllrydhqe rltakeamgh 361 pwfapireqi ek // LOCUS NP_012230 287 aa linear PLN 30-JUN-2025 DEFINITION F-actin-capping protein subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_012230 VERSION NP_012230.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179384.3 REFERENCE 1 (residues 1 to 287) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 287) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 287) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 287) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08514. On Jul 30, 2012 this sequence version replaced NP_012230.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..287 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..287 /product="F-actin-capping protein subunit beta" /calculated_mol_wt="32498" Region 11..256 /region_name="F_actin_cap_B" /note="F-actin capping protein, beta subunit; pfam01115" /db_xref="CDD:460070" CDS 1..287 /gene="CAP2" /locus_tag="YIL034C" /coded_by="NM_001179384.3:1..864" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:1315784]" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:36729023]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:1315784|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008290 F-actin capping protein complex [PMID:14769858]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:14769858]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051016 barbed-end actin filament capping [PMID:1315784|PMID:14769858]" /experiment="EXISTENCE:mutant phenotype:GO:0008290 F-actin capping protein complex [PMID:14769858]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:15645503]" /experiment="EXISTENCE:mutant phenotype:GO:0051015 actin filament binding [PMID:14769858]" /note="Beta subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches and the cytokinetic contractile ring; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress" /db_xref="GeneID:854777" /db_xref="SGD:S000001296" ORIGIN 1 msdaqfdaal dllrrlnptt lqenlnnlie lqpnlaqdll ssvdvplstq kdsadsnrey 61 lccdynrdid sfrspwsnty ypelspkdlq dspfpsaplr kleilandsf dvyrdlyyeg 121 gissvylwdl needfnghdf agvvlfkknq sdhsnwdsih vfevttspss pdsfnyrvtt 181 tiilhldktk tdqnshmmls gnltrqtekd iaidmsrpld viftshvanl gsliediesq 241 mrnlletvyf ektrdifhqt knaaiassae eankdaqaev irglqsl // LOCUS NP_012231 416 aa linear PLN 30-JUN-2025 DEFINITION cAMP-dependent protein kinase regulatory subunit BCY1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012231 VERSION NP_012231.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179383.1 REFERENCE 1 (residues 1 to 416) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 416) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 416) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 416) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08515. Method: conceptual translation. FEATURES Location/Qualifiers source 1..416 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..416 /product="cAMP-dependent protein kinase regulatory subunit BCY1" /calculated_mol_wt="47088" Region 5..48 /region_name="DD_R_ScPKA-like" /note="dimerization/docking (D/D) domain found in Saccharomyces cerevisiae cAMP-dependent protein kinase regulatory subunit and similar domains; cd12098" /db_xref="CDD:438519" Site order(5,9..10,13..14,17..18,21..22) /site_type="other" /note="putative AKAP interaction site [polypeptide binding]" /db_xref="CDD:438519" Site order(9,12..13,16..17,20..21,24..25,27..30,32..33,36,38,41) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:438519" Region 184..282 /region_name="CAP_ED" /note="effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038" /db_xref="CDD:237999" Site order(248..249,258..260) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:237999" Region 302..409 /region_name="CAP_ED" /note="effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038" /db_xref="CDD:237999" Site order(367..368,377..379) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:237999" Site order(399..401,405..407) /site_type="other" /note="flexible hinge region" /db_xref="CDD:237999" CDS 1..416 /gene="BCY1" /locus_tag="YIL033C" /gene_synonym="SRA1" /coded_by="NM_001179383.1:1..1251" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:26403272]" /experiment="EXISTENCE:direct assay:GO:0004862 cAMP-dependent protein kinase inhibitor activity [PMID:3037314]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18417610|PMID:3288487|PMID:11914276|PMID:11134339|PM ID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:11134339|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:2831892]" /experiment="EXISTENCE:direct assay:GO:0046580 negative regulation of Ras protein signal transduction [PMID:3037314]" /experiment="EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:12782684]" /experiment="EXISTENCE:mutant phenotype:GO:0004862 cAMP-dependent protein kinase inhibitor activity [PMID:6292221]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:26947009]" /experiment="EXISTENCE:mutant phenotype:GO:0010603 regulation of cytoplasmic mRNA processing body assembly [PMID:21925385]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:21925385|PMID:26947009]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:26947009]" /experiment="EXISTENCE:mutant phenotype:GO:0046580 negative regulation of Ras protein signal transduction [PMID:3037314]" /note="Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA); PKA is a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation; regulator of meiotic commitment" /db_xref="GeneID:854778" /db_xref="SGD:S000001295" ORIGIN 1 mvsslpkesq aelqlfqnei naanpsdflq fsanyfnkrl eqqraflkar epefkakniv 61 lfpepeesfs rpqsaqsqsr srssvmfksp fvnedphsnv fksgfnldph eqdthqqaqe 121 eqqhtrekts tpplpmhfna qrrtsvsget lqpnnfddwt pdhykekseq qlqrleksir 181 nnflfnklds dskrlvincl eeksvpkgat iikqgdqgdy fyvvekgtvd fyvndnkvns 241 sgpgssfgel almynspraa tvvatsdcll waldrltfrk illgssfkkr lmyddllksm 301 pvlkslttyd rakladaldt kiyqpgetii regdqgenfy lieygavdvs kkgqgvinkl 361 kdhdyfgeva llndlprqat vtatkrtkva tlgksgfqrl lgpavdvlkl ndptrh // LOCUS NP_012233 1034 aa linear PLN 30-JUN-2025 DEFINITION SUMO protease ULP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012233 VERSION NP_012233.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179381.1 REFERENCE 1 (residues 1 to 1034) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1034) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1034) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1034) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1034) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1034) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1034) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08516. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1034 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1034 /product="SUMO protease ULP2" /calculated_mol_wt="116752" Region 456..674 /region_name="Peptidase_C48" /note="Ulp1 protease family, C-terminal catalytic domain; pfam02902" /db_xref="CDD:397169" CDS 1..1034 /gene="ULP2" /locus_tag="YIL031W" /gene_synonym="SMT4" /coded_by="NM_001179381.1:1..3105" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:30575729]" /experiment="EXISTENCE:direct assay:GO:0003711 transcription elongation factor activity [PMID:31313851]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10713161]" /experiment="EXISTENCE:direct assay:GO:0008234 cysteine-type peptidase activity [PMID:10713161]" /experiment="EXISTENCE:direct assay:GO:0016926 protein desumoylation [PMID:10713161]" /experiment="EXISTENCE:direct assay:GO:0016929 deSUMOylase activity [PMID:10713161]" /experiment="EXISTENCE:mutant phenotype:GO:0006276 plasmid maintenance [PMID:11333221|PMID:10713161]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:10713162]" /experiment="EXISTENCE:mutant phenotype:GO:0016926 protein desumoylation [PMID:10713161]" /experiment="EXISTENCE:mutant phenotype:GO:0016929 deSUMOylase activity [PMID:10713161]" /experiment="EXISTENCE:mutant phenotype:GO:0030261 chromosome condensation [PMID:11333221]" /note="Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions, recovery from checkpoint arrest induced by DNA damage or DNA replication defect, and RNA splicing; potential Cdc28p substrate; human homolog PML implicated in promyelocytic leukemia can partially complement yeast null mutant" /db_xref="GeneID:854780" /db_xref="SGD:S000001293" ORIGIN 1 msarkrkfns lkpldtlnss rassprssas lppkryntfr kdpkivdhln nastkdflpv 61 lsmnseskrq ielsdndvdn ndegegvnsg csdqdfeplq ssplkrhssl kstsngllfq 121 msnnlgngsp epavastspn gsiistklnl ngqfscvdsk tlriyrhkap cimtfvsdhn 181 hpkfslyfqq sviynsqvnl lddveliild kknsfmaiil kdlkkvkmil dvnnssinin 241 tniliwstas sasnkkiksi krfllmsyss sikveildhk eqilerlkhl ihpissssps 301 lnmerainst knafdslrlk ktklstndde spqihthfls nkphglqslt krtriaslgk 361 kehsisvpks nispsdfynt ngtetlqsha vsqlrrsnrf kdvsdpansn snsefddatt 421 efetpelfkp slcykfndgs sytitnqdfk clfnkdwvnd sildfftkfy iessieksii 481 kreqvhlmss ffytklisnp adyysnvkkw vnntdlfskk yvvipinisy hwfsciitnl 541 daildfhqnk dkndainsde isinnplvni ltfdslrqth sreidpikef lisyaldkys 601 iqldktqikm ktcpvpqqpn msdcgvhvil nirkffenpv etidvwknsk ikskhftakm 661 inkyfdkner nsarknlrht lkllqlnyis ylkkenlyee vmqmeekkst ninnnenydd 721 ddeeiqiien idqsskdnna qltseppcsr sssisttere ptelhnsvvr qptgeiitdn 781 edpvraaspe tasvsppirh nilkssspfi sesaneteqe eftspyfgrp slktrakqfe 841 gvsspikndq alssthdimm pspkpkriyp skkipqlssh vqslstdsme rqsspnntni 901 visdteqdsr lgvnsesknt sgivnrddsd vnligsslpn vaeknhdntq esngnndslg 961 kilqnvdkel neklvdiddv afssptrgip rtsatskgsn aqllsnygde nnqsqdsvwd 1021 egrdnpille dedp // LOCUS NP_012234 1319 aa linear PLN 30-JUN-2025 DEFINITION E3 ubiquitin-protein ligase SSM4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012234 VERSION NP_012234.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179380.3 REFERENCE 1 (residues 1 to 1319) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1319) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1319) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1319) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08517. On Jul 30, 2012 this sequence version replaced NP_012234.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1319 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1319 /product="E3 ubiquitin-protein ligase SSM4" /EC_number="2.3.2.27" /calculated_mol_wt="151325" Region 22..1319 /region_name="SSM4" /note="E3 ubiquitin-protein ligase DOA10 [Posttranslational modification, protein turnover, chaperones]; COG5183" /db_xref="CDD:227510" CDS 1..1319 /gene="SSM4" /locus_tag="YIL030C" /gene_synonym="DOA10; KIS3" /coded_by="NM_001179380.3:1..3960" /experiment="EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:11641273]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11641273]" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:17051211]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11641273]" /experiment="EXISTENCE:direct assay:GO:0030970 retrograde protein transport, ER to cytosol [PMID:32588820]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:25918226]" /experiment="EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:32588820]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11641273|PMID:15252059]" /note="Membrane-embedded ubiquitin-protein ligase and retrotranslocase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); aids Cdc48p in the extraction of faulty membrane proteins; targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and Sbh2p, a transmembrane domain-containing substrate (ERAD-M); C-terminal element, conserved in human ortholog MARCH6, determines substrate selectivity" /db_xref="GeneID:854781" /db_xref="SGD:S000001292" ORIGIN 1 mdvdsdvnvs rlrdelhkva neetdtatfn ddapsgatcr icrgeatedn plfhpckcrg 61 sikymhescl lewvasknid iskpgadvkc dichypiqfk tiyaenmpek ipfslllsks 121 iltffekarl altiglaavl yiigvplvwn mfgklytmml dgsspypgdf lksliygydq 181 satpelttra ifyqllqnhs ftslqfimiv ilhialyfqy dmivredvfs kmvfhkigpr 241 lspkdlksrl kerfpmmddr mveylaremr ahdenrqeqg hdrlnmpaaa adnnnnvinp 301 rndnvppqdp ndhrnfenlr hvdeldhdea teehenndsd nslpsgddss rilpgsssdn 361 eedeeaegqq qqqqpeeead yrdhiepnpi dmwanrraqn efddliaaqq nainrpnapv 421 fipppaqnra gnvdqdeqdf gaavgvppaq anpddqgqgp lvinlklkll nviayfiiav 481 vftaiylais ylfptfigfg llkiyfgifk vilrglchly ylsgahiayn gltklvpkvd 541 vamswisdhl ihdiiylyng ytentmkhsi firalpaltt yltsvsivca ssnlvsrgyg 601 rengmsnptr rlifqilfal kctfkvftlf fielagfpil agvmldfslf cpilasnsrm 661 lwvpsicaiw ppfslfvywt igtlymywfa kyigmirkni irpgvlffir spedpnikil 721 hdslihpmsi qlsrlclsmf iyaifivlgf gfhtriffpf mlksnllsvp eaykptsiis 781 wkfntilltl yftkriless syvkpllery wktifklcsr klrlssfilg kdtpterghi 841 vyrnlfykyi aaknaewsnq elftkpktle qaeelfgqvr dvhayfvpdg vlmrvpssdi 901 vsrnyvqtmf vpvtkddkll kpldlerike rnkraagefg yldeqnteyd qyyivyvppd 961 frlrymtllg lvwlfasilm lgvtfisqal infvcsfgfl pvvklllger nkvyvawkel 1021 sdisysylni yyvcvgsvcl skiakdilhf tegqntldeh avdeneveev ehdiperdin 1081 napvnninnv eegqgifmai fnsifdsmlv kynlmvfiai miavirtmvs wvvltdgila 1141 cynyltirvf gnssytigns kwfkydesll fvvwiissmv nfgtgykslk lffrnrntsk 1201 lnflktmale lfkqgflhmv iyvlpiiils lvflrdvstk qiidishgsr sftlslnesf 1261 ptwtrmqdiy fgllialesf tfffqatvlf iqwfkstvqn vkdevytkgr alenlpdes // LOCUS NP_012235 142 aa linear PLN 30-JUN-2025 DEFINITION Ema17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012235 VERSION NP_012235.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179379.3 REFERENCE 1 (residues 1 to 142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 142) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08518. On Jul 30, 2012 this sequence version replaced NP_012235.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..142 /product="Ema17p" /calculated_mol_wt="16456" Region 1..>122 /region_name="DUF4668" /note="Domain of unknown function (DUF4668); pfam15701" /db_xref="CDD:406192" CDS 1..142 /gene="EMA17" /locus_tag="YIL029C" /coded_by="NM_001179379.3:1..429" /note="Protein involved in targeting mitochondrial membrane protein precursors to mitochondrial translocation system; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YIL029C has a paralog, YPR071W, that arose from a single-locus duplication" /db_xref="GeneID:854783" /db_xref="SGD:S000001291" ORIGIN 1 mrlifiakml qysflpfspf nllnfdnsis vswfitysvi vsiwgfavwi egayrnkinl 61 qlprctkikc sryntriksp kwfncknwmh ffllylflta snlivqlayf skemcsqgin 121 vpgtkkpgnr vylsviilmg ng // LOCUS NP_012237 141 aa linear PLN 30-JUN-2025 DEFINITION Emc5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012237 VERSION NP_012237.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179377.1 REFERENCE 1 (residues 1 to 141) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 141) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 141) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 141) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08519. Method: conceptual translation. FEATURES Location/Qualifiers source 1..141 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..141 /product="Emc5p" /calculated_mol_wt="15776" Region 9..129 /region_name="MMgT" /note="Membrane magnesium transporter; pfam10270" /db_xref="CDD:431186" CDS 1..141 /gene="EMC5" /locus_tag="YIL027C" /gene_synonym="KRE27" /coded_by="NM_001179377.1:1..426" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0072546 EMC complex [PMID:19325107]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]" /note="Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT" /db_xref="GeneID:854785" /db_xref="SGD:S000001289" ORIGIN 1 msfvskllyt vsalvlfhsg fssyefhhll klnslnnaqg aisklpkdim yetyaglilf 61 vlavftsfek lqylpiesnd gkiisqgnyl keialnkatn vdnligsnpn geiiftpsfv 121 dvhmkrkicr ewasntvkke k // LOCUS NP_012238 1150 aa linear PLN 30-JUN-2025 DEFINITION cohesin subunit IRR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012238 VERSION NP_012238.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179376.1 REFERENCE 1 (residues 1 to 1150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1150) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08520. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1150 /product="cohesin subunit IRR1" /calculated_mol_wt="132878" Region 74..881 /region_name="IRR1" /note="Cohesin [Cell division and chromosome partitioning]; COG5537" /db_xref="CDD:227824" CDS 1..1150 /gene="IRR1" /locus_tag="YIL026C" /gene_synonym="SCC3" /coded_by="NM_001179376.1:1..3453" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:9990856]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:10028182|PMID:28077952]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:28077952]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0030892 mitotic cohesin complex [PMID:9990856]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:9990856]" /note="Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in response to hypoxia; essential for viability" /db_xref="GeneID:854786" /db_xref="SGD:S000001288" ORIGIN 1 mtavrrstri rtksqvieed yddeqntsaq hvesdkitak tqheeeeeqd tgeseessse 61 ddyedqdddd yvdtatakrk srkrkpksas ntsskrqkkk ptsaqksavs hapayhrskk 121 dqdqyleiak dfqptelfdi lstsedvsie ellrewlety senrdkflqe finlllnccg 181 svarvedhdv hsnessneti geiqllfqrq klhefyllis kenkkrknfk mgplyqnfae 241 fmtkllevan dlqllyvesd eddtqivtgn lvldlltwls sfsvckircf ryistltlyl 301 fqdyltqqav nleknylakl skqlsleekk krpnnktlek lestiaetqg skvvidsiid 361 nivklcfvhr ykdvsdlirs esmlhlsiwi knypeyflkv tflkyfgwll sdnsvsvrlq 421 vtkilphlii qnhnskstdn sairqvferf ktkilevair dvnldvrihs iqvlteassl 481 gylddseili isslmfdeef dpfktssfnk rskflstvak flarvikekf defikthedl 541 pkevdglevg pvvqvgifik ilndsliyhl kdcaevdsrt kirmltqaae flspyisthl 601 kticnllisd tesneliqkl qnsannnsdd edvddeeldi tplfpidrns tilylnvfhg 661 lcagannpki qtkdsvkeiv lplfydllna asiesadilc pllesfitfs lddwisigye 721 telkkitdkt ikafmdstig nskvdmkydi fakfihhihh fekkelqekf lnqiatlkih 781 lkkflqekmd pnnsrddykd ltcslyelyi nkltilgrdy pievdeellq lflnnfvsri 841 pimfqdfdds taqeinfkml vllatwnlek wreiiekvrd yensiskdlr svwkpiaaii 901 grlntlvisl aatnetfeni nslfylkwsa ctslmdiiva ikifelklpa dattwrysms 961 eqfpfylhdn askvllkifl yleslfakqv dvqlervade danlndlpet gffenietef 1021 llftvklkgl mklnilderf asrvalnkek lgplfkkivd dtimenpepn kkniqkaksn 1081 qtqrekaplq pnseretdha ntenndpdip mtidlepiee ssqnnselap ieehptvvda 1141 idnsdeitqd // LOCUS NP_012240 189 aa linear PLN 30-JUN-2025 DEFINITION Atg45p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012240 VERSION NP_012240.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179374.3 REFERENCE 1 (residues 1 to 189) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 189) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 189) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 189) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08521. On Jul 30, 2012 this sequence version replaced NP_012240.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..189 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..189 /product="Atg45p" /calculated_mol_wt="21660" Region 19..92 /region_name="E_set_AMPKbeta_like_N" /note="N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; cd02859" /db_xref="CDD:199889" Site order(31,63,71,82..84,86,88) /site_type="other" /note="glycogen binding site [chemical binding]" /db_xref="CDD:199889" CDS 1..189 /gene="ATG45" /locus_tag="YIL024C" /coded_by="NM_001179374.3:1..570" /experiment="EXISTENCE:direct assay:GO:0005776 autophagosome [PMID:38832010]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:38832010]" /experiment="EXISTENCE:direct assay:GO:2001069 glycogen binding [PMID:38832010]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:38832010]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:38832010]" /experiment="EXISTENCE:mutant phenotype:GO:0061723 glycophagy [PMID:38832010]" /note="Autophagy receptor for glycogen; cytosolic receptor for glycogen that mediates glycophagy, the autophagy of glycogen; induced during prolonged nitrogen starvation and highly expressed during sporulation, both glycophagy-inducing conditions; expression directly regulated by Ume6p, a metabolic and meiotic transcriptional regulator; contains a glycogen-binding domain (GBD) and an Atg8 family-interacting motif (AIM) proposed to facilitate sequestration of glycogen by autophagic isolation membranes" /db_xref="GeneID:854788" /db_xref="SGD:S000001286" ORIGIN 1 msnfllvipe dvikgcskad klvvtgefdn wrhsdyvlqy dgstqnyrvq iprrkgqrst 61 mfkvvindkk wvtlnyfdtv tdksgytnni lhfkdneasq lmdiplspht rsntakgkpe 121 ddslndyvnl sshsdlsste eivcwnsdme denmdatiqc dfhqafnsrk eslnglmcia 181 kkvktywnk // LOCUS NP_012241 346 aa linear PLN 30-JUN-2025 DEFINITION Zn(2+) transporter YKE4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012241 VERSION NP_012241.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179373.1 REFERENCE 1 (residues 1 to 346) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 346) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 346) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 346) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08522. Method: conceptual translation. FEATURES Location/Qualifiers source 1..346 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..346 /product="Zn(2+) transporter YKE4" /calculated_mol_wt="37287" Region 63..344 /region_name="Zip" /note="ZIP Zinc transporter; pfam02535" /db_xref="CDD:396884" CDS 1..346 /gene="YKE4" /locus_tag="YIL023C" /coded_by="NM_001179373.1:1..1041" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:16760462]" /experiment="EXISTENCE:mutant phenotype:GO:0005385 zinc ion transmembrane transporter activity [PMID:16760462]" /experiment="EXISTENCE:mutant phenotype:GO:0006829 zinc ion transport [PMID:16760462]" /note="Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family" /db_xref="GeneID:854789" /db_xref="SGD:S000001285" ORIGIN 1 mkashicsyl lsiaplvvsh gvhhnrdhgh eanheskqsf lilkqesify slvcflqnhl 61 fvlgprynai vailiiqlmp clfvlfvpgl rkndrasltl sllvsfslgt llgdillhvi 121 peslsgvtdv tmvggaiflg fisfltldkt mrilsgtsnd dgsihshshs htpqqtaekk 181 agfnmsayln visgiahhit dgialatsfy sstqvgimts iavtfheiph elgdfaills 241 sgftfpqair aqavtafgav vgtsigcwmn eignnshkat sssanaselm lpftaggliy 301 iattsvvpqi lhssapdskl refkkwalql vfifvgfavm almdeh // LOCUS NP_012242 431 aa linear PLN 30-JUN-2025 DEFINITION protein translocase subunit TIM44 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012242 VERSION NP_012242.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179372.1 REFERENCE 1 (residues 1 to 431) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 431) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 431) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 431) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08523. Method: conceptual translation. FEATURES Location/Qualifiers source 1..431 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..431 /product="protein translocase subunit TIM44" /calculated_mol_wt="48723" Region 56..421 /region_name="3a0801s03tim44" /note="mitochondrial import inner membrane, translocase subunit; TIGR00984" /db_xref="CDD:130057" CDS 1..431 /gene="TIM44" /locus_tag="YIL022W" /gene_synonym="ISP45; MIM44; MPI1" /coded_by="NM_001179372.1:1..1296" /experiment="EXISTENCE:direct assay:GO:0001405 PAM complex, Tim23 associated import motor [PMID:14638855|PMID:14517234]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:1396562|PMID:18400944]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:11344168|PMID:10824101]" /experiment="EXISTENCE:mutant phenotype:GO:0051087 protein-folding chaperone binding [PMID:11344168]" /experiment="EXISTENCE:physical interaction:GO:0051087 protein-folding chaperone binding [PMID:7809127]" /note="Essential component of the TIM23 complex; tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex); TIM23 complex is short for the translocase of the inner mitochondrial membrane" /db_xref="GeneID:854790" /db_xref="SGD:S000001284" ORIGIN 1 mhrstfirts gtssrtltar yrsqytgllv arvlfststt raqggnprsp lqifrdtfkk 61 eweksqelqe niktlqdasg klgeseaykk areaylkaqr gstivgktlk ktgetmehia 121 tkaweselgk ntrkaaaata kkldesfepv rqtkiykevs eviddgessr yggfitkeqr 181 rlkrerdlas gkrhravksn edagtavvat nieskesfgk kvedfkektv vgrsiqslkn 241 klwdesenpl ivvmrkitnk vggffaetes srvysqfklm dptfsnesft rhlreyivpe 301 ileayvkgdv kvlkkwfsea pfnvyaaqqk ifkeqdvyad grildirgve ivsakllapq 361 dipvlvvgcr aqeinlyrkk ktgeiaagde anilmssyam vftrdpeqid ddetegwkil 421 efvrggsrqf t // LOCUS NP_012243 318 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase II core subunit RPB3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012243 VERSION NP_012243.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179371.3 REFERENCE 1 (residues 1 to 318) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 318) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 318) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 318) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08524. On Jul 30, 2012 this sequence version replaced NP_012243.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..318 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..318 /product="DNA-directed RNA polymerase II core subunit RPB3" /calculated_mol_wt="35167" Region 6..265 /region_name="RNAP_II_RPB3" /note="RPB3 subunit of Eukaryotic RNA polymerase II; cd07031" /db_xref="CDD:132909" Site order(6..8,13..14,22,26,28..29,32,35,165..166,241,245, 248..249,252,258..259,262,265) /site_type="other" /note="RPB3 - RPB11 heterodimer interface [polypeptide binding]" /db_xref="CDD:132909" Site order(31,34..35,39,59,61..62,65..66,167..168,173..175, 177..178,180..181,188..190,192,194,201..202) /site_type="other" /note="RPB3 - RPB2 interaction site [polypeptide binding]" /db_xref="CDD:132909" Site order(46..52,60,65,166..167,169) /site_type="other" /note="RPB3 - RPB12 interaction site [polypeptide binding]" /db_xref="CDD:132909" Site order(57,66,69,112,114,141..143,146,148,169,174..175,233, 235) /site_type="other" /note="RPB3 - RPB10 interaction site [polypeptide binding]" /db_xref="CDD:132909" Site order(187,221) /site_type="other" /note="RPB3 - RPB8 interaction site [polypeptide binding]" /db_xref="CDD:132909" Site order(192..194,221) /site_type="other" /note="RPB3 - RPB1 interaction site [polypeptide binding]" /db_xref="CDD:132909" CDS 1..318 /gene="RPB3" /locus_tag="YIL021W" /coded_by="NM_001179371.3:1..957" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:8288647]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15520468]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1331084|PMID:2183013|PMID:2186966]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:2685562]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:16537912]" /note="RNA polymerase II third largest subunit B44; part of central core; similar to prokaryotic alpha subunit" /db_xref="GeneID:854791" /db_xref="SGD:S000001283" ORIGIN 1 mseegpqvki reaskdnvdf ilsnvdlama nslrrvmiae iptlaidsve vetnttvlad 61 efiahrlgli plqsmdieql eysrdcfced hcdkcsvvlt lqafgesest tnvyskdlvi 121 vsnlmgrnig hpiiqdkegn gvlicklrkg qelkltcvak kgiakehakw gpaaaiefey 181 dpwnklkhtd ywyeqdsake wpqsknceye dppnegdpfd ykaqadtfym nvesvgsipv 241 dqvvvrgidt lqkkvasill altqmdqdkv nfasgdnnta snmlgsnedv mmtgaeqdpy 301 snasqmgntg sggydnaw // LOCUS NP_012244 261 aa linear PLN 30-JUN-2025 DEFINITION 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012244 VERSION NP_012244.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179370.3 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08525. On Jul 30, 2012 this sequence version replaced NP_012244.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..261 /product="1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase HIS6" /EC_number="5.3.1.16" /calculated_mol_wt="29426" Region 2..258 /region_name="hisA_euk" /note="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, eukaryotic type; TIGR02129" /db_xref="CDD:162719" Site order(9,57,136) /site_type="active" /db_xref="CDD:240074" CDS 1..261 /gene="HIS6" /locus_tag="YIL020C" /coded_by="NM_001179370.3:1..786" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000105 L-histidine biosynthetic process [PMID:9332345]" /experiment="EXISTENCE:genetic interaction:GO:0003949 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity [PMID:9332345]" /experiment="EXISTENCE:mutant phenotype:GO:0000105 L-histidine biosynthetic process [PMID:14190241|PMID:9332345]" /note="Enzyme that catalyzes the fourth step in the histidine pathway; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts" /db_xref="GeneID:854792" /db_xref="SGD:S000001282" ORIGIN 1 mtkfigcidl hngevkqivg gtltskkedv pktnfvsqhp ssyyaklykd rdvqgchvik 61 lgpnnddaar ealqespqfl qvgggindtn clewlkwask vivtswlftk eghfqlkrle 121 rltelcgkdr ivvdlscrkt qdgrwivamn kwqtltdlel nadtfrelrk ytneflihaa 181 dveglcggid ellvsklfew tkdyddlkiv yaggaksvdd lklvdelshg kvdltfgssl 241 difggnlvkf edccrwnekq g // LOCUS NP_012245 346 aa linear PLN 30-JUN-2025 DEFINITION Faf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012245 VERSION NP_012245.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179369.1 REFERENCE 1 (residues 1 to 346) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 346) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 346) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 346) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08526. Method: conceptual translation. FEATURES Location/Qualifiers source 1..346 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..346 /product="Faf1p" /calculated_mol_wt="38758" CDS 1..346 /gene="FAF1" /locus_tag="YIL019W" /coded_by="NM_001179369.1:1..1041" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15178413|PMID:15078877]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15078877|PMID:15178413]" /note="Protein required for pre-rRNA processing; also required for 40S ribosomal subunit assembly" /db_xref="GeneID:854793" /db_xref="SGD:S000001281" ORIGIN 1 mtlddddyik qmelqrkafe sqfgslesmg fedktknirt evdtrdssgd eidnsdhgsd 61 fkdgtiessn ssdedsgnet aeennqdskp ktqpkvirfn gpsdvyvpps kktqkllrsg 121 ktltqinkkl esteakeeke detleaenlq ndlelqqflr eshllsafnn ggsgstnsgv 181 sltlqsmggg nddgivyqdd qvigkarsrt lemrlnrlsr vnghqdkink lekvpmhirr 241 gmidkhvkri kkyeqeaaeg givlskvkkg qfrkiestyk kdierriggs ikardkekat 301 krerglkiss vgrstrngli vskrdiaris ggersgkfng kkksrr // LOCUS NP_012246 254 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL2 RPL2B [Saccharomyces cerevisiae S288C]. ACCESSION NP_012246 VERSION NP_012246.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179368.1 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08527. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..254 /product="60S ribosomal protein uL2 RPL2B" /calculated_mol_wt="27277" Region 1..252 /region_name="PTZ00180" /note="60S ribosomal protein L8; Provisional" /db_xref="CDD:173464" CDS 1..254 /gene="RPL2B" /locus_tag="YIL018W" /gene_synonym="LOT2; RPL5A" /coded_by="NM_001179368.1:1..765" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L2B; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2B has a paralog, RPL2A, that arose from the whole genome duplication; expression is upregulated at low temperatures" /db_xref="GeneID:854794" /db_xref="SGD:S000001280" ORIGIN 1 mgrvirnqrk gagsiftsht rlrqgaaklr tldyaerhgy irgivkqivh dsgrgaplak 61 vvfrdpykyr lreeifiane gvhtgqfiya gkkaslnvgn vlplgsvpeg tivsnveekp 121 gdrgalaras gnyviiighn pdenktrvrl psgakkviss dargvigvia gggrvdkpll 181 kagrafhkyr lkrnswpktr gvamnpvdhp hgggnhqhig kastisrgav sgqkagliaa 241 rrtgllrgsq ktqd // LOCUS NP_012247 921 aa linear PLN 30-JUN-2025 DEFINITION glucose-induced degradation complex subunit VID28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012247 VERSION NP_012247.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179367.3 REFERENCE 1 (residues 1 to 921) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 921) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 921) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 921) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 921) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 921) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 921) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08528. On Jul 30, 2012 this sequence version replaced NP_012247.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..921 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..921 /product="glucose-induced degradation complex subunit VID28" /calculated_mol_wt="105361" Region 1..918 /region_name="COG5369" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227663" Region 586..610 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 621..651 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..921 /gene="VID28" /locus_tag="YIL017C" /gene_synonym="GID5; YIL017W" /coded_by="NM_001179367.3:1..2766" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0034657 GID complex [PMID:18508925|PMID:16872538]" /experiment="EXISTENCE:mutant phenotype:GO:0007039 protein catabolic process in the vacuole [PMID:15358789]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:12586695]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:15358789|PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]" /note="GID Complex subunit, serves as adaptor for regulatory subunit Vid24p; protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm" /db_xref="GeneID:854795" /db_xref="SGD:S000001279" ORIGIN 1 mtvayslenl kkisnslvgd qlakvdyfla pkcqifqcll sieqsdgvel knakldllyt 61 llhlepqqrd ivgtyyfdiv saiyksmsla ssftknnsst nykyikllnl cagvypncgf 121 pdlqylqngf iqlvnhkflr skckidevvt iiellklfll vdekncsdfn kskfmeeere 181 vtetshyqdf kmaeslehii vkisskyldq islkyivrlk vsrpaspssv kndpfdnkgv 241 dctraipkki nisnmydssl lslalllylr yhymipgdrk lrndatfkmf vlgllksndv 301 nircvalkfl lqpyftedkk wedtrtleki lpylvksfny dplpwwfdpf dmldslivly 361 neitpmnnpv lttlahtnvi fcilsrfaqc lslpqhneat lktttkfiki casfaasdek 421 yrllllndtl llnhleygle shitliqdfi slkdeikett teshsmclpp iydhdfvaaw 481 llllksfsrs vsalrttlkr nkiaqlllqi lsktytltke cyfagqdfmk peimimgitl 541 gsicnfvvef snlqsfmlrn giidiiekml tdplfnskka wddnederri alqgipvhev 601 kanslwvlrh lmyncqneek fqllakipmn lildfindpc wavqaqcfql lrnltcnsrk 661 ivnillekfk dveykidpqt gnkisigsty lfeflakkmr llnpldtqqk kamegilyii 721 vnlaavnenk kqlvieqdei lnimseilve tttdsssngn dsnlklaclw vlnnllwnss 781 vshytqyaie nglepghsps dsenpqstvt igynesvagg ysrgkyydep dgddsssnan 841 ddedddndeg ddegdefvrt paakgstsnv qvtratverc rklvevglyd lvrknitdes 901 lsvrekartl lyhmdlllkv k // LOCUS NP_012248 159 aa linear PLN 30-JUN-2025 DEFINITION Snl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012248 VERSION NP_012248.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179366.1 REFERENCE 1 (residues 1 to 159) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 159) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 159) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 159) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08529. Method: conceptual translation. FEATURES Location/Qualifiers source 1..159 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..159 /product="Snl1p" /calculated_mol_wt="18175" Region 73..159 /region_name="BAG" /note="BAG domains, present in regulator of Hsp70 proteins; smart00264" /db_xref="CDD:214591" CDS 1..159 /gene="SNL1" /locus_tag="YIL016W" /coded_by="NM_001179366.1:1..480" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:9450961]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9450961]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:22635919]" /experiment="EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:9450961]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:12105220]" /note="Ribosome-associated protein; proposed to act in protein synthesis, nuclear pore complex biogenesis and maintenance as well as protein folding and prion maintenance; has similarity to the mammalian BAG-1 protein" /db_xref="GeneID:854796" /db_xref="SGD:S000001278" ORIGIN 1 mshnamehwk sklsktstst yvllaviavv flvtirrpng skgksskkra skknkkgknq 61 fekapvpltl eeqidnvslr ygnelegrsk dlinrfdved ekdiyernyc nemllkllie 121 ldsidlinvd eslrrplkek rkgvikeiqa mlksldslk // LOCUS NP_012249 587 aa linear PLN 30-JUN-2025 DEFINITION aspartyl protease BAR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012249 VERSION NP_012249.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179365.1 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08530. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..587 /product="aspartyl protease BAR1" /EC_number="3.4.23.35" /calculated_mol_wt="63599" Region 43..395 /region_name="SAP_like" /note="SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins; cd05474" /db_xref="CDD:133141" Site order(44,126,129,134,140,176,363) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:133141" Site order(63..66,287..290) /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:133141" Site order(63,287) /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:133141" Site order(127..132,134..138) /site_type="active" /note="Active site flap [active]" /db_xref="CDD:133141" CDS 1..587 /gene="BAR1" /locus_tag="YIL015W" /gene_synonym="SST1" /coded_by="NM_001179365.1:1..1764" /experiment="EXISTENCE:direct assay:GO:0000747 conjugation with cellular fusion [PMID:6345506]" /experiment="EXISTENCE:direct assay:GO:0004190 aspartic-type endopeptidase activity [PMID:9249020]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:3124102]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10438739]" /experiment="EXISTENCE:direct assay:GO:0043171 peptide catabolic process [PMID:9249020]" /experiment="EXISTENCE:direct assay:GO:0071444 cellular response to pheromone [PMID:6345506]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:7050666]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:7050666]" /note="Aspartyl protease secreted to periplasmic space of mating type a cell; helps cells monitor availability of mating partners; cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest" /db_xref="GeneID:854797" /db_xref="SGD:S000001277" ORIGIN 1 msainhlclk lilasfaiin titaltndgt ghlefllqhe eemyyattld igtpsqsltv 61 lfdtgsadfw vmdssnpfcl pnsntssysn atyngeevkp sidcrsmsty nehrsstyqy 121 lengrfyity adgtfadgsw gtetvsingi dipniqfgva kyattpvsgv lgigfprres 181 vkgyegapne yypnfpqilk sekiidvvay slflnspdsg tgsivfgaid eskfsgdlft 241 fpmvneypti vdapatlamt iqglgaqnks scehetfttt kypvlldsgt sllnapkvia 301 dkmasfvnas yseeegiyil dcpvsvgdve ynfdfgdlqi svplsslils petegsycgf 361 avqptndsmv lgdvflssay vvfdldnyki slaqanwnas evskklvniq tdgsisgaki 421 ataepwstne pftvtsdiys stgcksrpfl qsstasslia etnvqsrncs tkmpgtrstt 481 vlskptqnsa mhqstgavtq tsnetklels stmansgsvs lptsnsidke fehsksqtts 541 dpsvaehstf nqtfvhetky rpthktvite tvtkystvli nvckpty // LOCUS NP_012250 104 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL014C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012250 VERSION NP_012250.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181433.3 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08531. On Jul 30, 2012 this sequence version replaced NP_012250.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..104 /product="uncharacterized protein" /calculated_mol_wt="11533" CDS 1..104 /locus_tag="YIL014C-A" /gene_synonym="YIL015C-A" /coded_by="NM_001181433.3:1..315" /note="hypothetical protein; null mutant shows improved incorporation efficiency of noncanonical amino acids in place of amber stop codon" /db_xref="GeneID:854799" /db_xref="SGD:S000003536" ORIGIN 1 mdidmnypsi ttlmsnesan lliiwgnatp disylsyttn pmlgdyvlnv saingcteel 61 iathlvptle natqwvydag eywdnysftd estplpglsw pfne // LOCUS NP_012251 630 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,3-mannosyltransferase MNT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012251 VERSION NP_012251.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179364.3 REFERENCE 1 (residues 1 to 630) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 630) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 630) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 630) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08532. On Jul 30, 2012 this sequence version replaced NP_012251.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..630 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..630 /product="alpha-1,3-mannosyltransferase MNT3" /calculated_mol_wt="72279" Region 234..514 /region_name="Mannosyl_trans3" /note="Mannosyltransferase putative; pfam11051" /db_xref="CDD:402574" CDS 1..630 /gene="MNT3" /locus_tag="YIL014W" /coded_by="NM_001179364.3:1..1893" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:30700649]" /experiment="EXISTENCE:genetic interaction:GO:0000033 alpha-1,3-mannosyltransferase activity [PMID:10521541]" /experiment="EXISTENCE:genetic interaction:GO:0006493 protein O-linked glycosylation [PMID:10521541]" /experiment="EXISTENCE:mutant phenotype:GO:0000033 alpha-1,3-mannosyltransferase activity [PMID:10521541]" /experiment="EXISTENCE:mutant phenotype:GO:0006493 protein O-linked glycosylation [PMID:10521541]" /note="Alpha-1,3-mannosyltransferase; adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation" /db_xref="GeneID:854801" /db_xref="SGD:S000001276" ORIGIN 1 mlkslksrrl ilkrlvtlll slffsylifs asrnvtssnk lnnhaserta vessafnwie 61 krqhqvrsen lmnrlsayfl pflsrsshke rvllrqlgnn eiaksdkcry ifevlykidp 121 dwdnaqtakf ynvdgvdntl asllgerlrs ydycflsgql dptaifanst vnphdlqnrm 181 fpflkkinee sktvmwpiit dmttgeavpa pevdmessnf ngnfwsnwnr lskgrgfvlt 241 iaekdvplfl kqlkvmefsk nelpfqivst gnelsaesia kisetakete qrvylvdcst 301 vldtnfanty isffqnkwva tlfntfeeyi lldadvvpfv gsdyffdsps yresgillfk 361 drvmeneqtf qyciemlnev epsaqerrfi gsrlvfdssl pfssetseea svyynffkkl 421 rlhhvdsglv vvnkleklng llmsfmlnld gklqrcvygd keifwlgqly agqdysinpv 481 dgsiigpvne ependdghks gmyyicstqi ahsdsknrll wvngglktck isnsaeddfg 541 repeyfksry gdisklkriy daslnvegli vpdvsvhpwm qikecsnymy cayatgdght 601 nseldegrli tftekelryi ndisrtwnan // LOCUS NP_012252 1411 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette multidrug transporter PDR11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012252 VERSION NP_012252.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179363.1 REFERENCE 1 (residues 1 to 1411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1411) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08533. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1411 /product="ATP-binding cassette multidrug transporter PDR11" /calculated_mol_wt="160407" Region 56..1381 /region_name="3a01205" /note="Pleiotropic Drug Resistance (PDR) Family protein; TIGR00956" /db_xref="CDD:273362" CDS 1..1411 /gene="PDR11" /locus_tag="YIL013C" /coded_by="NM_001179363.1:1..4236" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:33375075]" /experiment="EXISTENCE:direct assay:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:28922409]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0035376 sterol import [PMID:12077145|PMID:21110944]" /experiment="EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:12077145]" /experiment="EXISTENCE:mutant phenotype:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:28922409]" /note="ATP-binding cassette (ABC) transporter; multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromised; regulated by Pdr1p; required for anaerobic growth; PDR11 has a paralog, AUS1, that arose from the whole genome duplication" /db_xref="GeneID:854802" /db_xref="SGD:S000001275" ORIGIN 1 mslskyfnpi pdasvtfdga tvqleeslga vqndeesase fknvghleis ditfranege 61 vvlvlgnpts alfkglfhgh khlkyspegs irfkdneykq faskcphqii ynneqdihfp 121 yltveqtidf alsckfhipk qeriemrdel lkefglshvk ktyvgndyvr gvsggerkri 181 siietfiang svylwdnstk gldsatalef lsitqkmaka trsvnfvkis qasdkivskf 241 dkilmlgdsf qvfygtmeec lthfhdtlqi kknpndciie yltsilnfkf ketsnsivgl 301 dtpsvvseen qalninnetd lhtlwiqspy ykhwkaitsk tvqectrkdv npddispifs 361 iplktqlktc tvraferiig drnylisqfv svvvqslvig slfynipltt igsfsrgslt 421 ffsilfftfl sladmpasfq rqpvvrkhvq lhfyynwvet latnffdccs kfilvvifti 481 ilyflahlqy naarffifll flsvynfcmv slfaltalia ptlsmanlla gilllaiamy 541 asyviymkdm hpwfiwiayl npamfameai lsnelfnlkl dchesiiprg eyydnisfsh 601 kacawqgatl gndyvrgrdy lksglkytyh hvwrnfgiii gflcfflfcs llaaeyitpl 661 ftrenllrwn nylkrycpfl nsqkknnksa itnndgvctp ktpianfsts sssvpsvshq 721 ydtdynikhp detvnnhtke svametqkhv iswkninyti gdkklindas gyissgltal 781 mgesgagktt llnvlsqrte sgvvtgelli dgqpltnida frrsigfvqq qdvhlelltv 841 resleiscvl rgdgdrdylg vvsnllrlps eklvadlspt qrkllsigve lvtkpslllf 901 ldeptsglda eaaltivqfl kklsmqgqai lctihqpsks visyfdniyl lkrggecvyf 961 gslpnacdyf vahdrrltfd remdnpadfv idvvgsgstn ipmddaekpt sskidepvsy 1021 hkqsdsinwa elwqsspekv rvaddlllle eearksgvdf ttsvwsppsy meqiklitkr 1081 qyictkrdmt yvfakyalna gaglfigfsf wrtkhningl qdaiflcfmm lcvssplinq 1141 vqdkalqske vyiarearsn tyhwtvllia qtivelplai ssstlfflcc yfccgfetsa 1201 rvagvfylny ilfsmyylsf glwllysapd lqtaavfvaf lysftasfcg vmqpyslfpr 1261 fwtfmyrvsp ytyfietfvs lllhdrevnc stsemvpsqp vmgqtcgqfm kpfidefggk 1321 lhinntytvc aycmytvgdd flaqenmsyh hrwrnfgfew vfvcfniaam fvgfyltyik 1381 kiwpsvidgi kkcipsmrrs ktshnpneqs v // LOCUS NP_001335785 113 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL012W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335785 VERSION NP_001335785.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348845.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80305. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..113 /product="uncharacterized protein" /calculated_mol_wt="13104" CDS 1..113 /locus_tag="YIL012W" /coded_by="NM_001348845.1:1..342" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:854803" /db_xref="SGD:S000001274" ORIGIN 1 mclgklyfeq lilvrcikgr qsgnittges rcvswnvyct tsmiglfswr kmllfqhfsy 61 tqrenrqigg ktwslisslf hlnetlasal hhpyetlaly eayfalrekk fll // LOCUS NP_012254 269 aa linear PLN 30-JUN-2025 DEFINITION Tir3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012254 VERSION NP_012254.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179361.1 REFERENCE 1 (residues 1 to 269) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 269) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 269) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 269) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08534. Method: conceptual translation. FEATURES Location/Qualifiers source 1..269 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..269 /product="Tir3p" /calculated_mol_wt="26177" Region 20..116 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..269 /gene="TIR3" /locus_tag="YIL011W" /gene_synonym="YIB1" /coded_by="NM_001179361.1:1..810" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Cell wall mannoprotein; member of Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; TIR3 has a paralog, TIR2, that arose from the whole genome duplication" /db_xref="GeneID:854804" /db_xref="SGD:S000001273" ORIGIN 1 msftkiaall avaaastqlv saevgqyeiv efdailadvk anleqymsla mnnpdftlps 61 gvldvyqhmt tatddsytsy ftemdfaqit tamvqvpwys srlepeiiaa lqsagisits 121 lgqtvsesgs esatassdas sasesssaas ssasesssaa sssasesssa asssasesss 181 aasssaseaa kssssakssg ssaassaass asskassaas ssakasssae kstnssssat 241 sknagaamdm gffsagvgaa iagaaamll // LOCUS NP_012255 215 aa linear PLN 30-JUN-2025 DEFINITION thioredoxin peroxidase DOT5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012255 VERSION NP_012255.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179360.3 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08535. On Jul 30, 2012 this sequence version replaced NP_012255.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..215 /product="thioredoxin peroxidase DOT5" /EC_number="1.11.1.24" /calculated_mol_wt="23989" Region 67..207 /region_name="PRX_BCP" /note="Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; cd03017" /db_xref="CDD:239315" Site order(104,107,175) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:239315" CDS 1..215 /gene="DOT5" /locus_tag="YIL010W" /coded_by="NM_001179360.3:1..648" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2408019|PMID:10681558]" /experiment="EXISTENCE:direct assay:GO:0008379 thioredoxin peroxidase activity [PMID:10681558]" /experiment="EXISTENCE:direct assay:GO:0045454 cell redox homeostasis [PMID:10681558]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:15051715]" /experiment="EXISTENCE:mutant phenotype:GO:0008379 thioredoxin peroxidase activity [PMID:10681558]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:10681558]" /note="Nuclear thiol peroxidase; functions as an alkyl-hydroperoxide reductase during post-diauxic growth" /db_xref="GeneID:854805" /db_xref="SGD:S000001272" ORIGIN 1 mgealrrstr iaiskrmlee eesklapist pevpkkkikt gpkhnanqav vqeanrssdv 61 neleigdpip dlsllnednd sislkkiten nrvvvffvyp rastpgctrq acgfrdnyqe 121 lkkyaavfgl sadsvtsqkk fqskqnlpyh llsdpkrefi gllgakktpl sgsirshfif 181 vdgklkfkrv kispevsvnd akkevlevae kfkee // LOCUS NP_012256 181 aa linear PLN 30-JUN-2025 DEFINITION telomerase subunit EST3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012256 VERSION NP_012256.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184306.2 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08536. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..181 /product="telomerase subunit EST3" /calculated_mol_wt="20423" Region 20..146 /region_name="TPP1" /note="Shelterin complex subunit, TPP1/ACD; pfam10341" /db_xref="CDD:431220" CDS 1..181 /gene="EST3" /locus_tag="YIL009C-A" /coded_by="join(NM_001184306.2:1..276, NM_001184306.2:278..547)" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:20884318]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12101098]" /experiment="EXISTENCE:direct assay:GO:0005697 telomerase holoenzyme complex [PMID:10898986]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0007004 telomere maintenance via telomerase [PMID:10898986]" /experiment="EXISTENCE:direct assay:GO:0033677 DNA/RNA helicase activity [PMID:16884717]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:16884717]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:20884318]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:8978029]" /ribosomal_slippage="" /note="Component of the telomerase holoenzyme; involved in telomere replication; synthesis of the full-length protein results from a programmed +1 ribosomal frameshift" /db_xref="GeneID:854806" /db_xref="SGD:S000006432" ORIGIN 1 mpkvileshs kptdsvflqp wikaliedns ehdqyhpsgh vipsltkqdl alphmsptil 61 tnpchfakit kfynvcdykv yasirdsshq ilvefsqecv snferthncr itsettnclm 121 iigdadlvyv tnsramshfk iclsnisske ivpvlnvnqa tifdidqvgs lstfpfvyky 181 l // LOCUS NP_012257 694 aa linear PLN 30-JUN-2025 DEFINITION long-chain fatty acid-CoA ligase FAA3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012257 VERSION NP_012257.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179359.1 REFERENCE 1 (residues 1 to 694) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 694) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 694) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 694) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08537. Method: conceptual translation. FEATURES Location/Qualifiers source 1..694 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..694 /product="long-chain fatty acid-CoA ligase FAA3" /EC_number="6.2.1.3" /calculated_mol_wt="77816" Region 95..678 /region_name="LC_FACS_euk1" /note="Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; cd17639" /db_xref="CDD:341294" Site order(267,270..275,277..278) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341294" Site order(270,393..394,450..455,534,546,549,561,670) /site_type="other" /note="putative AMP binding site [chemical binding]" /db_xref="CDD:341294" Site order(270,312..313,364,366..367,370,393..394,450..455,534, 546,549,558..561,647) /site_type="active" /note="putative active site [active]" /db_xref="CDD:341294" Site order(312,366..367,370,393,558..560,645,647) /site_type="other" /note="putative CoA binding site [chemical binding]" /db_xref="CDD:341294" CDS 1..694 /gene="FAA3" /locus_tag="YIL009W" /coded_by="NM_001179359.1:1..2085" /experiment="EXISTENCE:direct assay:GO:0004467 long-chain fatty acid-CoA ligase activity [PMID:8206942]" /experiment="EXISTENCE:direct assay:GO:0031957 very long-chain fatty acid-CoA ligase activity [PMID:8206942]" /experiment="EXISTENCE:genetic interaction:GO:0001676 long-chain fatty acid metabolic process [PMID:7962057]" /note="Long chain fatty acyl-CoA synthetase; activates imported fatty acids with a preference for C16:0-C18:0 chain lengths; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery" /db_xref="GeneID:854808" /db_xref="SGD:S000001271" ORIGIN 1 mseqhsvavg kaanehetap rrnvrvkkrp lirplnssas tlyefalecf nkggkrdgma 61 wrdvieihet kktivrkvdg kdksiektwl yyemspykmm tyqeliwvmh dmgrglakig 121 ikpngehkfh ifastshkwm kiflgcisqg ipvvtaydtl gesglihsmv etesaaiftd 181 nqllakmivp lqsakdikfl ihnepidpnd rrqngklyka akdainkire vrpdikiysf 241 eevvkigkks kdevklhppe pkdlacimyt sgsisapkgv vlthynivsg iagvghnvfg 301 wigstdrvls flplahifel vfefeafywn gilgygsvkt ltntstrnck gdlvefkpti 361 migvaavwet vrkailekis dltpvlqkif wsaysmkeks vpctgflsrm vfkkvrqatg 421 ghlkyimngg saisidaqkf fsivlcpmii gygltetvan acvlepdhfe ygivgdlvgs 481 vtaklvdvkd lgyyaknnqg elllkgapvc seyyknpiet avsftydgwf rtgdivewtp 541 kgqlkiidrr knlvktlnge yialeklesv yrsnsyvkni cvyadesrvk pvgivvpnpg 601 plskfavklr imkkgedien yihdkalrna vfkemiatak sqglvgiell cgivffdeew 661 tpengfvtsa qklkrreila avksevervy kens // LOCUS NP_012258 99 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-related modifier URM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012258 VERSION NP_012258.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179358.3 REFERENCE 1 (residues 1 to 99) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 99) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 99) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 99) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08538. On Jul 30, 2012 this sequence version replaced NP_012258.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..99 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..99 /product="ubiquitin-related modifier URM1" /calculated_mol_wt="10897" Region 3..99 /region_name="Urm1" /note="Urm1 (Ubiquitin related modifier); pfam09138" /db_xref="CDD:370315" CDS 1..99 /gene="URM1" /locus_tag="YIL008W" /coded_by="NM_001179358.3:1..300" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:14551258]" /experiment="EXISTENCE:direct assay:GO:0031386 protein tag activity [PMID:14551258|PMID:10713047]" /experiment="EXISTENCE:direct assay:GO:0032447 protein urmylation [PMID:14555475|PMID:10713047]" /experiment="EXISTENCE:direct assay:GO:0034599 cellular response to oxidative stress [PMID:21209336]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:14551258]" /experiment="EXISTENCE:genetic interaction:GO:0007114 cell budding [PMID:14551258]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:14551258]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0002143 tRNA wobble position uridine thiolation [PMID:19151091|PMID:19145231|PMID:18664566]" /experiment="EXISTENCE:mutant phenotype:GO:0031386 protein tag activity [PMID:14551258]" /experiment="EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14555475]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:14555475]" /note="Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; functions as a protein tag involved in the urmylation of proteins involved in nutrient sensing and the oxidative stress response; regulates stress-dependent condensate formation, promoting phase separation of numerous proteins to promote stress resilience and survival; forms co-condensates with Uba4p resulting in increased target urmylation" /db_xref="GeneID:854809" /db_xref="SGD:S000001270" ORIGIN 1 mvnvkveflg gldaifgkqr vhkikmdked pvtvgdlidh ivstminnpn dvsifiedds 61 irpgiitlin dtdwelegek dyiledgdii sftstlhgg // LOCUS NP_012259 220 aa linear PLN 30-JUN-2025 DEFINITION Nas2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012259 VERSION NP_012259.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179357.3 REFERENCE 1 (residues 1 to 220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 220) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08539. On Jul 30, 2012 this sequence version replaced NP_012259.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..220 /product="Nas2p" /calculated_mol_wt="24715" Region 31..109 /region_name="Nas2_N" /note="Nas2 N_terminal domain; pfam18265" /db_xref="CDD:465689" Region <131..>214 /region_name="RseP" /note="Membrane-associated protease RseP, regulator of RpoE activity [Posttranslational modification, protein turnover, chaperones, Transcription]; COG0750" /db_xref="CDD:440513" CDS 1..220 /gene="NAS2" /locus_tag="YIL007C" /coded_by="NM_001179357.3:1..663" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19446323]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11489916]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:19446323]" /experiment="EXISTENCE:direct assay:GO:0070682 proteasome regulatory particle assembly [PMID:19446322]" /experiment="EXISTENCE:genetic interaction:GO:0044183 protein folding chaperone [PMID:19446323]" /experiment="EXISTENCE:genetic interaction:GO:0070682 proteasome regulatory particle assembly [PMID:19446323|PMID:19446322]" /experiment="EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19446323|PMID:19446322]" /note="Evolutionarily conserved 19S regulatory particle assembly-chaperone; involved in assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); non-essential gene; interacts with Rpn4p; protein abundance increases in response to DNA replication stress; ortholog of human p27" /db_xref="GeneID:854810" /db_xref="SGD:S000001269" ORIGIN 1 meeeelskll anvkidpslt srisqidsfk lselmvlktd ietqleayfs vleqqgigmd 61 salvtpdgyp rsdvdvlqvt mirknvnmlk ndlnhllqrs hvllnqhfdn mnvksnqdar 121 rnnddqaiqy tipfafisev vpgspsdkad ikvddklisi gnvhaanhsk lqniqmvvmk 181 nedrplpvll lregqilkts ltpsrnwngr gllgcriqel // LOCUS NP_012260 373 aa linear PLN 30-JUN-2025 DEFINITION NAD+ transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_012260 VERSION NP_012260.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179356.1 REFERENCE 1 (residues 1 to 373) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 373) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 373) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 373) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08540. Method: conceptual translation. FEATURES Location/Qualifiers source 1..373 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..373 /product="NAD+ transporter" /calculated_mol_wt="41823" Region 75..171 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 176..268 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 274..365 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..373 /gene="YIA6" /locus_tag="YIL006W" /gene_synonym="NDT1" /coded_by="NM_001179356.1:1..1122" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16291748|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0035352 NAD transmembrane transport [PMID:16291748]" /experiment="EXISTENCE:direct assay:GO:0051724 NAD transmembrane transporter activity [PMID:16291748]" /experiment="EXISTENCE:genetic interaction:GO:0035352 NAD transmembrane transport [PMID:16291748]" /experiment="EXISTENCE:genetic interaction:GO:0051724 NAD transmembrane transporter activity [PMID:16291748]" /experiment="EXISTENCE:mutant phenotype:GO:0006850 pyruvate import into mitochondria [PMID:12887330]" /experiment="EXISTENCE:mutant phenotype:GO:0035352 NAD transmembrane transport [PMID:16291748]" /experiment="EXISTENCE:mutant phenotype:GO:0051724 NAD transmembrane transporter activity [PMID:16291748]" /note="Mitochondrial NAD+ transporter; involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs; YIA6 has a paralog, YEA6, that arose from the whole genome duplication; human NAD+ transporter MCART1/SLC25A51 functionally complements the yia6 yea6 double null mutant, and yeast YIA6 reciprocally complements defects in MCART1/SLC25A51 null cells" /db_xref="GeneID:854811" /db_xref="SGD:S000001268" ORIGIN 1 mtqtdnpvpn cgllpeqqyc sadheeplll heeqlifpdh ssqlssadii epikmnsste 61 siigttlrkk wvplsstqit alsgafagfl sgvavcpldv aktrlqaqgl qtrfenpyyr 121 gimgtlstiv rdegprglyk glvpivlgyf ptwmiyfsvy efskkffhgi fpqfdfvaqs 181 caaitagaas ttltnpiwvv ktrlmlqsnl gehpthykgt fdafrklfyq egfkalyagl 241 vpsllglfhv aihfpiyedl kvrfhcysre nntnsinlqr limassvskm iasavtyphe 301 ilrtrmqlks dipdsiqrrl fplikatyaq eglkgfysgf ttnlvrtipa saitlvsfey 361 frnrlenist mvi // LOCUS NP_012261 701 aa linear PLN 30-JUN-2025 DEFINITION protein disulfide isomerase EPS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012261 VERSION NP_012261.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179355.1 REFERENCE 1 (residues 1 to 701) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 701) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 701) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 701) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08541. Method: conceptual translation. FEATURES Location/Qualifiers source 1..701 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..701 /product="protein disulfide isomerase EPS1" /EC_number="5.3.4.1" /calculated_mol_wt="81088" Region 33..139 /region_name="Thioredoxin" /note="pfam00085" /db_xref="CDD:395038" Site order(60,63) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239259" Region <404..>472 /region_name="PTZ00102" /note="disulphide isomerase; Provisional" /db_xref="CDD:240266" CDS 1..701 /gene="EPS1" /locus_tag="YIL005W" /coded_by="NM_001179355.1:1..2106" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10545109]" /experiment="EXISTENCE:direct assay:GO:0019153 protein-disulfide reductase (glutathione) activity [PMID:16002399]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16002399]" /experiment="EXISTENCE:mutant phenotype:GO:0003756 protein disulfide isomerase activity [PMID:11157982]" /experiment="EXISTENCE:mutant phenotype:GO:0006621 protein retention in ER lumen [PMID:10545109]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:12881414]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:16002399]" /note="ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family" /db_xref="GeneID:854812" /db_xref="SGD:S000001267" ORIGIN 1 mkmnlkrlvv tffscitfll kftiaaaepp egfpeplnpt nfkeelskgl hiidfyspyc 61 phckhlapvw metweefkee sktlnitfsq vnciesadlc gdenieyfpe irlynpsgyi 121 ksftetprtk esliafarre smdpnnldtd ldsaksesqy legfdfleli agkatrphlv 181 sfwptkdmkn sddslefknc dkchefqrtw kiisrqlavd dintghvnce snpticeelg 241 fgdlvkitnh radrepkval vlpnktsnnl fdypngysak sdgyvdfarr tftnskfpni 301 tegelekkan rdidflqerg rvtnndihlv fsydpetvvi edfdileyli eplskipniy 361 lhqidknlin lsrnlfgrmy ekinydasqt qkvfnkeyft mntvtqlptf fmfkdgdpis 421 yvfpgystte mrnidaimdw vkkysnplvt evdssnlkkl isfqtksysd laiqlisstd 481 hkhikgsnkl iknlllaswe yehirmennf eeinerrark adgikkikek kapankivdk 541 mreeiphmdq kklllgyldi skeknffrky gitgeykigd viiidksnny yynkdnfgns 601 ltsnnpqllr eafvslnips kalyssklkg rlinspfhnv lsfldiihgn gmpgyliviv 661 lfiailkgps iyrrykvrkh yrakrnavgi lgnmekkknq d // LOCUS NP_012262 142 aa linear PLN 30-JUN-2025 DEFINITION Bet1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012262 VERSION NP_012262.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179354.3 REFERENCE 1 (residues 1 to 142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 142) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08542. On Jul 30, 2012 this sequence version replaced NP_012262.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..142 /product="Bet1p" /calculated_mol_wt="15589" Region 55..112 /region_name="SNARE_Bet1" /note="SNARE motif of Bet1; cd15853" /db_xref="CDD:277206" Site order(59..62,64..66,68..70,72..73,75..80,82..83,85..86, 89..90,92..94,96..98,100..101,103..104,107..108,110..111) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277206" Site 86 /site_type="other" /note="zero layer" /db_xref="CDD:277206" CDS 1..142 /gene="BET1" /locus_tag="YIL004C" /gene_synonym="SLY12" /coded_by="NM_001179354.3:1..429" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11001058]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:1396561]" /experiment="EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9813082]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:1396561]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11001058]" /experiment="EXISTENCE:mutant phenotype:GO:0005484 SNAP receptor activity [PMID:3312234]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:3312234]" /note="Type II membrane protein required for vesicular transport; required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins" /db_xref="GeneID:854813" /db_xref="SGD:S000001266" ORIGIN 1 mssrfaggna yqrdtgrtql fgpadgsnsl ddnvssalgs tdkldysqst laslesqsee 61 qmgamgqrik alkslslkmg deirgsnqti dqlgdtfhnt svklkrtfgn mmemarrsgi 121 siktwliiff mvgvlffwvw it // LOCUS NP_012263 293 aa linear PLN 30-JUN-2025 DEFINITION iron-sulfur cluster assembly protein CFD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012263 VERSION NP_012263.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179353.1 REFERENCE 1 (residues 1 to 293) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 293) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 293) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 293) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08543. Method: conceptual translation. FEATURES Location/Qualifiers source 1..293 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..293 /product="iron-sulfur cluster assembly protein CFD1" /calculated_mol_wt="31791" Region 15..271 /region_name="ParA" /note="NUBPL iron-transfer P-loop NTPase; pfam10609" /db_xref="CDD:431392" Site order(26..33,168,170,195..196,232..234,237..238) /site_type="active" /db_xref="CDD:349757" Site order(26..28,57..58,60,63..64,111..112,142,144,147,174,177, 233,235..236,238) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:349757" CDS 1..293 /gene="CFD1" /locus_tag="YIL003W" /gene_synonym="DRE3" /coded_by="NM_001179353.1:1..882" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12970194]" /experiment="EXISTENCE:direct assay:GO:0016226 iron-sulfur cluster assembly [PMID:17401378]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:26195633]" /experiment="EXISTENCE:direct assay:GO:0051539 4 iron, 4 sulfur cluster binding [PMID:17401378]" /experiment="EXISTENCE:direct assay:GO:1904564 cytosolic [4Fe-4S] assembly scaffold complex [PMID:26195633]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:12970194]" /note="Highly conserved iron-sulfur cluster binding protein; localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol" /db_xref="GeneID:854814" /db_xref="SGD:S000001265" ORIGIN 1 meeqeigvpa aslagikhii lilsgkggvg kssvttqtal tlcsmgfkvg vldidltgps 61 lprmfglene siyqgpegwq pvkvetnstg slsvislgfl lgdrgnsviw rgpkktsmik 121 qfisdvawge ldyllidtpp gtsdehisia eelryskpdg givvttpqsv atadvkkein 181 fckkvdlkil giienmsgfv cphcaectni fssgggkrls eqfsvpylgn vpidpkfvem 241 ienqvsskkt lvemyressl cpifeeimkk lrkqdtttpv vdkheqpqie spk // LOCUS NP_878098 69 aa linear PLN 30-JUN-2025 DEFINITION Cmi7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878098 VERSION NP_878098.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184653.1 REFERENCE 1 (residues 1 to 69) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 69) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 69) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 69) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08544. Method: conceptual translation. FEATURES Location/Qualifiers source 1..69 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..69 /product="Cmi7p" /calculated_mol_wt="7598" CDS 1..69 /gene="CMI7" /locus_tag="YIL002W-A" /coded_by="NM_001184653.1:1..210" /note="Putative mitochondrial hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466493" /db_xref="SGD:S000028835" ORIGIN 1 mtrdtpedvs tagakdildv lnllkggeek isevelklde mekkmdsllv qledlhrdnn 61 dlaksssqk // LOCUS NP_012264 946 aa linear PLN 30-JUN-2025 DEFINITION phosphoinositide 5-phosphatase INP51 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012264 VERSION NP_012264.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179352.3 REFERENCE 1 (residues 1 to 946) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 946) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 946) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 946) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08545. On Jul 30, 2012 this sequence version replaced NP_012264.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..946 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..946 /product="phosphoinositide 5-phosphatase INP51" /EC_number="3.1.3.36" /calculated_mol_wt="108299" Region 1..501 /region_name="COG5329" /note="Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]" /db_xref="CDD:227637" Region 498..946 /region_name="COG5411" /note="Phosphatidylinositol 5-phosphate phosphatase [Signal transduction mechanisms]" /db_xref="CDD:227698" CDS 1..946 /gene="INP51" /locus_tag="YIL002C" /gene_synonym="SJL1" /coded_by="NM_001179352.3:1..2841" /experiment="EXISTENCE:direct assay:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:9565610|PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17452534]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9560389]" /experiment="EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10224048]" /experiment="EXISTENCE:mutant phenotype:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:9438131|PMID:9565610]" /experiment="EXISTENCE:mutant phenotype:GO:0046856 phosphatidylinositol dephosphorylation [PMID:9560389|PMID:9438131]" /note="Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth" /db_xref="GeneID:854815" /db_xref="SGD:S000001264" ORIGIN 1 mrlfigrrsr sivissnnyc lsfqrlrsip gassqqrqls ktpsvtiksy pdtdlssdsn 61 ylevkscifn gllglvclng diyvavisgv qnvgfprwkl idhqvrpses iykvldvdfy 121 slendvfdyl lcerseqnyd klihehpcgp lkklfsdgtf yysrdfdisn ivknhglshn 181 leytvdnqdl sfiwnanlas evinwrskis neekqlfana gfltfvirgy cktaliedgp 241 ntasitiisr isteskqdtl elegisedgr vslfveteiv vttekfifsy tqvngsiplf 301 wesvesqlly gkkikvtkds ieaqgafdrh fdnltskygv vsivniikpk sesqeklalt 361 ykdcaeskgi kitnieysss vltksphkll yllkqdiyef gafaydisrg iyfakqtgvl 421 risafdsiek pntverlvsk evlelttnei dvfeltspfl dahdklwsen yywldrtytk 481 htknsgkytk vysklfgsrv rlydplhiyi sqylkqlrsk ytfekdisif agtfnisgki 541 pkddikdwif pksmskedem adlyviglee vveltpghml atdpyvrqfw ekkiltllng 601 pgrkkkyirl wstqlggill llfmneteys kvkhiegdvk ktgfggmasn kgavavsfky 661 satrfcvlvs hlaaglenve qrhndyktia ksirfskglr ikdhdaiiwm gdfnyrilms 721 nedvrrkivs keyaslfekd qlnqqmiage sfpyfhemai dfpptykfdp gtknydtsek 781 mripawtdri lsrgevleql eykccedilf sdhrpvyaif rarvtvvdeq kkttlgtqiy 841 ekimerlegl dddekiavls ddafviesfe gsdsiagpth sptpipepkr grklpppssd 901 lkkwwigsgk qvkvvldvdp avyminpkrd pnpfvenede plfier // LOCUS NP_012265 513 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIL001W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012265 VERSION NP_012265.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179351.3 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08546. On Jul 30, 2012 this sequence version replaced NP_012265.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..513 /product="uncharacterized protein" /calculated_mol_wt="59601" Region <13..>66 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 41..66 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 123..202 /region_name="BTB_POZ_ZBTB_KLHL-like" /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; cd18186" /db_xref="CDD:349497" Region 261..391 /region_name="BTB2_POZ_ABTB1_BPOZ1" /note="second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); cd18296" /db_xref="CDD:349605" Region 393..464 /region_name="BACK_ABTB1_BPOZ" /note="BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); cd18497" /db_xref="CDD:350572" CDS 1..513 /locus_tag="YIL001W" /coded_by="NM_001179351.3:1..1542" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm" /db_xref="GeneID:854816" /db_xref="SGD:S000001263" ORIGIN 1 madklmdknf eelcyscrtg dmdnvdrlis tgvnvnsvdk fdnsplflas lcgheavvkl 61 llqrgavcdr dryegarciy galtdtirdt llsydiskav dvkqpfathi ssmyndegfl 121 krditfrvsn gklftahkfl lcarseilae kmvnewakhe ivslevrpdi fdiflkflyl 181 ipilhqiepg qyeelielss kfdiellpef ldkarhtadp teksrlmsdy qykftevars 241 qllifvnnci frstvdlans errvfslmnc paypdvqlmv knrngairiy pchlavlsra 301 eyfkvmftnn fkekvtyika khvtgkynsi ipqltlpnce fevaeiilry lyadntdipw 361 myavdvllla dilledrlkt iastiitqsk efiqqynvfd vlylsweigv erleqfaakf 421 iaihlqelyk dpeikraiml ssqrislrqe tdtielvddi ryyllrkysf epddvelfen 481 qddleylkqv gyleyrkdmg mldniladle ldv // LOCUS NP_012266 250 aa linear PLN 30-JUN-2025 DEFINITION Sgn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012266 VERSION NP_012266.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179523.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08547. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..250 /product="Sgn1p" /calculated_mol_wt="28823" Region <52..>202 /region_name="PABP-1234" /note="polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628" /db_xref="CDD:130689" Region 65..137 /region_name="RRM_II_PABPs" /note="RNA recognition motif in type II polyadenylate-binding proteins; cd12306" /db_xref="CDD:409747" CDS 1..250 /gene="SGN1" /locus_tag="YIR001C" /gene_synonym="RBP1; RBP29" /coded_by="NM_001179523.1:1..753" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10764794]" /experiment="EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:10764794]" /experiment="EXISTENCE:genetic interaction:GO:0016071 mRNA metabolic process [PMID:10764794]" /experiment="EXISTENCE:physical interaction:GO:0016071 mRNA metabolic process [PMID:10764794]" /note="Cytoplasmic RNA-binding protein; contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation" /db_xref="GeneID:854817" /db_xref="SGD:S000001440" ORIGIN 1 msqeekvdak atlkteisnn kkndkqelel delvgklsie gtpqvsqkls keekhahqle 61 adsrsifvgn itpdvtpeqi edhfkdcgqi kritllydrn tgtpkgygyi efespayrek 121 alqlnggelk gkkiavsrkr tnipgfnrhy nsqnqyfqqw qwnyplmayp npdtfpyypp 181 yppnqspnqn fgynknnyyr spynnknrtf qkkhfnsakd stknirstsq kpvvmpsdnv 241 ksstqekdsk // LOCUS NP_012267 993 aa linear PLN 30-JUN-2025 DEFINITION 3'-5' DNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012267 VERSION NP_012267.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179524.1 REFERENCE 1 (residues 1 to 993) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 993) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 993) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 993) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 993) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 993) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 993) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08548. Method: conceptual translation. FEATURES Location/Qualifiers source 1..993 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..993 /product="3'-5' DNA helicase" /EC_number="3.6.4.12" /calculated_mol_wt="113927" Region 85..265 /region_name="DEXDc_FANCM" /note="DEAH-box helicase domain of FANCM; cd18033" /db_xref="CDD:350791" Site order(85..88,91,108..115,150,210,241) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350791" Region 86..>690 /region_name="MPH1" /note="ERCC4-related helicase [Replication, recombination and repair]; COG1111" /db_xref="CDD:440728" Site order(138..139,165..166,185,187..188,191,216..218) /site_type="other" /note="nucleic acid binding site [nucleotide binding]" /db_xref="CDD:350791" CDS 1..993 /gene="MPH1" /locus_tag="YIR002C" /coded_by="NM_001179524.1:1..2982" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19995966|PMID:10880470]" /experiment="EXISTENCE:direct assay:GO:0033677 DNA/RNA helicase activity [PMID:26966248]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:15634678]" /experiment="EXISTENCE:direct assay:GO:0060543 negative regulation of strand invasion [PMID:19136626]" /experiment="EXISTENCE:direct assay:GO:0070336 flap-structured DNA binding [PMID:19181670]" /experiment="EXISTENCE:genetic interaction:GO:0033567 DNA replication, Okazaki fragment processing [PMID:19181670]" /experiment="EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:19995966]" /experiment="EXISTENCE:mutant phenotype:GO:0007535 donor selection [PMID:27257873]" /experiment="EXISTENCE:mutant phenotype:GO:0060543 negative regulation of strand invasion [PMID:19136626]" /experiment="EXISTENCE:physical interaction:GO:0007535 donor selection [PMID:27257873]" /note="3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds flap DNA, stimulates activity of Rad27p and Dna2p; prevents crossovers between ectopic sequences by removing substrates for Mus81-Mms4 or Rad1-Rad10 cleavage; homolog of human FANCM Fanconi anemia protein that is involved in stabilizing and remodeling blocked replication forks; member of SF2 DExD/H superfamily of helicases; nonsense or missense mutations in FANCM predispose individuals to breast cancer" /db_xref="GeneID:854818" /db_xref="SGD:S000001441" ORIGIN 1 masaddyfsd feddeldkly ekainksvke titrravpvq kdlhdnvlpg qktvyeeiqr 61 dvsfgpthhe ldydalsfyv yptnyevrdy qytivhkslf qntlcaiptg mgktfiastv 121 mlnyfrwtkk akiiftaptr plvaqqikac lgitgipsdq tailldksrk nreeiwankr 181 vffatpqvve ndlkrgvldp kdivclvide ahratgssay tnvvkfidrf nssyrllalt 241 atpasdlegv qevvnnldis kieirteesm divkymkkrk kekievplll eiediieqlg 301 mavkpvlqqa ielgiyeecd psqinafkam qqsqkiianp tipegikwrn ffilqllnnv 361 gqmlkrlkiy girtffnyfq nkctefttky nlkkstnkia aefyyhpilk niknqcenyl 421 sdpkfvghgk lqcvrdelmd ffqkrgsdsr viiftelres aleivkfids vaddqirphi 481 figqarakeg fdevkytrkh apkgrkkver lhrqeqekfl eaertkraan dklersarrt 541 gsseeaqisg mnqkmqkevi hnfkkgeynv lvctsigeeg ldigevdlii cydttsspik 601 niqrmgrtgr krdgkivllf ssnesykfer amedystlqa liskqcidyk ksdriipedi 661 ipechetlit indeneiine medvdeviry atqcmmgkkv kpkkaitkkk rvqenkkpkk 721 ffmpdnvets ivsastlink flvnesggkq lvtsnenpsk krkifkaldn lendsteeas 781 ssletedeev sddnnvfiae gqngcqkdle taiirtgesl ttlkplhnfe rpnmalfvnd 841 cglptkiekn vkdirgnqhn lekeksctvd knnmvlsldd wnffrnryip egvsfdvepn 901 fvqytkgvkv phchkvskii tlfndesndn kkrtidmnyt kclargmlrd ekkfvkvndk 961 sqvdnnsvnh dssqsftlsn aelddilgsd sdf // LOCUS NP_012268 679 aa linear PLN 30-JUN-2025 DEFINITION Aim21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012268 VERSION NP_012268.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179525.3 REFERENCE 1 (residues 1 to 679) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 679) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 679) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 679) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08549. On Jul 30, 2012 this sequence version replaced NP_012268.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..679 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..679 /product="Aim21p" /calculated_mol_wt="74632" CDS 1..679 /gene="AIM21" /locus_tag="YIR003W" /coded_by="NM_001179525.3:1..2040" /experiment="EXISTENCE:direct assay:GO:0015629 actin cytoskeleton [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:29467252|PMID:28706108]" /experiment="EXISTENCE:direct assay:GO:0030837 negative regulation of actin filament polymerization [PMID:29467252]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:29467252]" /experiment="EXISTENCE:mutant phenotype:GO:0034642 mitochondrion migration along actin filament [PMID:19300474]" /experiment="EXISTENCE:physical interaction:GO:0110131 Aim21-Tda2 complex [PMID:29467252|PMID:28706108]" /note="Subunit of a complex that associates with actin filaments; forms a complex with Tda2p that inhibits barbed end F-actin assembly; elevates actin monomer pools to increase endocytotic efficiency and to regulate the distribution of actin between cables and patches; Aim21p/Tda2p forms a larger complex with actin capping proteins Cap1p and Cap2p; involved in mitochondrial migration along actin filaments; recruited to cortical actin patches by SH3 domain-containing proteins Bbc1p and Abp1p" /db_xref="GeneID:854819" /db_xref="SGD:S000001442" ORIGIN 1 mpsevtpkvp erpsrrktse lfplsgsesg dikanseppt pagtpnvptr rpilkaktmt 61 sfesgmdqes lpkvplqrpv rrstteelnn vmnntskele eiesliskhn ihnvsrkksp 121 tsveegkvaa ihqngqrsas dnktstnpsp leknehegae gnesaispsn lvnksnnevt 181 ehsdsedlte kqkvhaaldn eagdrshfee klipgdmkvq vdvskdveeg slnalppsgi 241 tesddkaekf tkhpesslee lqkhqeqqee kifqnptdee sttslnekqe gkdnmevnsq 301 pqgpsdtetv iaatssnvps qiaseeendv pviprsrpkk dfeahvqkee lpntqekrvs 361 eecdstlist eeeskipkip serpkrrapp pvpkkpssri aafqemlqkq qqqdlhnngn 421 ssattasadi akkhtdssit sdttkadfts klnglfalpg mvnpgqlpps lekklsspdt 481 esklgpqdqs qaktgplggt rrgrgprgrk lpskvasvek ieeddntnki eifnnwnvss 541 sfskekvlid ttpgeqaera ldeksksipe eqreqspnkm eaalcpfeld ekeklpanae 601 sdplsqlpqt navgnrkais eeslspseai anrdqndtte iqeqqmedqm evdmerelsg 661 gyedvdsalh seeasfhsl // LOCUS NP_012269 432 aa linear PLN 30-JUN-2025 DEFINITION Djp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012269 VERSION NP_012269.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179526.1 REFERENCE 1 (residues 1 to 432) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 432) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 432) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 432) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08550. Method: conceptual translation. FEATURES Location/Qualifiers source 1..432 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..432 /product="Djp1p" /calculated_mol_wt="48444" Region 7..>97 /region_name="PRK10767" /note="chaperone protein DnaJ; Provisional" /db_xref="CDD:236757" Region 208..422 /region_name="DnaJ-X" /note="X-domain of DnaJ-containing; pfam14308" /db_xref="CDD:433858" CDS 1..432 /gene="DJP1" /locus_tag="YIR004W" /gene_synonym="ICS1; PAS22" /coded_by="NM_001179526.1:1..1299" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9679141]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:30213914]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:9679141]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:23959800]" /note="ER-associated chaperone involved in protein targeting; redirects mitochondrial membrane protein precursors to mitochondrial translocation system; required for peroxisomal protein import and involved in peroxisome assembly; facilitates import of Mim1p and Mim2p into the mitochondrial outer membrane; homologous to E. coli DnaJ" /db_xref="GeneID:854820" /db_xref="SGD:S000001443" ORIGIN 1 mvvdteyydl lgvsttassi eikkayrkks iqehpdknpn dptaterfqa iseayqvlgd 61 ddlrakydky grkeaipqgg fedaaeqfsv ifggdafasy igelmllknl qkteelnaed 121 eaekekenve tmeespadgk tngttnavda algntnekdd knkarttsgn ltvhdgnkkn 181 eqvgaeakkk ktkleqfeee qevekqkrvd qlsktlierl siltesvydd ackdsfkkkf 241 eeeanllkme sfgldilhti gdvyyekaei flasqnlfgm ggifhsmkak ggvfmdtlrt 301 vsaaidaqnt mkelekmkea stnneplfdk dgneqikptt eelaqqeqll mgkvlsaawh 361 gskyeitstl rgvckkvled dsvskktlir raeamkllge vfkktfrtkv eqeeaqifee 421 lvaeatkkkr ht // LOCUS NP_012270 148 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit IST3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012270 VERSION NP_012270.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179527.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08551. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..148 /product="U2 snRNP complex subunit IST3" /calculated_mol_wt="16967" Region 22..109 /region_name="RRM_ist3_like" /note="RNA recognition motif (RRM) found in ist3 family; cd12411" /db_xref="CDD:409845" CDS 1..148 /gene="IST3" /locus_tag="YIR005W" /gene_synonym="SNU17" /coded_by="NM_001179527.1:1..447" /experiment="EXISTENCE:direct assay:GO:0000384 first spliceosomal transesterification activity [PMID:11287609]" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:15565172]" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:16314500]" /experiment="EXISTENCE:direct assay:GO:0070274 RES complex [PMID:15565172]" /experiment="EXISTENCE:mutant phenotype:GO:0000245 spliceosomal complex assembly [PMID:11287609]" /experiment="EXISTENCE:mutant phenotype:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:11287609]" /experiment="EXISTENCE:mutant phenotype:GO:0000384 first spliceosomal transesterification activity [PMID:11287609]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:15565172]" /note="Component of the U2 snRNP; required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing; diploid mutants have a specific defect in MATa1 pre-mRNA splicing which leads to haploid gene expression in diploids" /db_xref="GeneID:854821" /db_xref="SGD:S000001444" ORIGIN 1 mnkiqqindk elqsgilsph qswhneykdn ayiyignlnr eltegdiltv fseygvpvdv 61 ilsrdentge sqgfaylkye dqrstilavd nlngfkiggr alkidhtfyr pkrslqkyye 121 avkeeldrdi vsknnaekli lakkdqpn // LOCUS NP_012271 1480 aa linear PLN 30-JUN-2025 DEFINITION actin cytoskeleton-regulatory complex protein PAN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012271 VERSION NP_012271.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179528.3 REFERENCE 1 (residues 1 to 1480) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1480) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1480) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1480) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08552. On Jul 30, 2012 this sequence version replaced NP_012271.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1480 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1480 /product="actin cytoskeleton-regulatory complex protein PAN1" /calculated_mol_wt="160137" Region 144..243 /region_name="DUF1720" /note="Domain of unknown function (DUF1720); pfam08226" /db_xref="CDD:369766" Region 265..356 /region_name="EH" /note="Eps15 homology domain; smart00027" /db_xref="CDD:197477" Region <391..453 /region_name="DUF1720" /note="Domain of unknown function (DUF1720); pfam08226" /db_xref="CDD:369766" Region 459..553 /region_name="DUF1720" /note="Domain of unknown function (DUF1720); pfam08226" /db_xref="CDD:369766" Region 595..688 /region_name="EH" /note="Eps15 homology domain; smart00027" /db_xref="CDD:197477" Region <833..>934 /region_name="MAT1" /note="CDK-activating kinase assembly factor MAT1; pfam06391" /db_xref="CDD:461894" Region 982..>1127 /region_name="PAT1" /note="Topoisomerase II-associated protein PAT1; pfam09770" /db_xref="CDD:401645" Region <1064..1125 /region_name="Amelogenin" /note="Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth; smart00818" /db_xref="CDD:197891" CDS 1..1480 /gene="PAN1" /locus_tag="YIR006C" /gene_synonym="DIM2; MDP3; MIP3" /coded_by="NM_001179528.3:1..4443" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17967424]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17967424]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:16824951|PMID:14622601]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0071933 Arp2/3 complex binding [PMID:11433303]" /experiment="EXISTENCE:direct assay:GO:1990964 actin cytoskeleton-regulatory complex [PMID:17151356|PMID:10594004]" /experiment="EXISTENCE:direct assay:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:11433303|PMID:16824951|PMID:17151356]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]" /experiment="EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:18177206]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8978817]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:8756649]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:8756649]" /experiment="EXISTENCE:physical interaction:GO:1990964 actin cytoskeleton-regulatory complex [PMID:17151356]" /note="Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p; associates with actin patches on cell cortex; promotes protein-protein interactions essential for endocytosis; regulates late stages of endocytosis; binds to and activates Arp2/3 complex in vitro; phosphorylation of Thr-1225 is regulated by MAPK Hog1p in response to osmotic stress" /db_xref="GeneID:854822" /db_xref="SGD:S000001445" ORIGIN 1 mynpyqqqgm gyqqqqqqqq qqpngfypqq qqgqssnqpq gqpqpqqqma fnqpqatgig 61 gmpqsfgnsf ssmpqqpqtg ynnngnngsv ygngnfgqqp qqqqqqakpq htgyvpnssm 121 pmmnttgtmp ppnpaqqpql qsiqpqgtgy yqaantanvh svqplqsqgt gyyvstpnli 181 ssnqtqqplq aqgtgyyqsq pqqvpppqqa qslqplkpqq tgfylqpqnq apleplkpta 241 tgfvnsfann glnndikipa irlsfitaqd qakfetlfrs ivtngsntvs gancrkilmr 301 sglppsqlar iwtlcdtska gellfpefal amhlindvlq gdtipyelds ktknevssfi 361 dainlsianq dssandapkt pfdefitagv qnlqpqptgy mpqtsfgipl qsqitgggva 421 salnpqstgf mapttfnmsm ntgtpglnpq itggapasmq pnitgnalqp qttgmmpqtt 481 gmmpqttgmm pqtsfgvnlg pqltggalqs qytggygsvm pqqsgpasmp nlsfnqqglq 541 sqltglqpqp tgflppsnfs atmpltaqkt gfgnneiytk snfnnnlidn ssqdkistee 601 kslfykifet fdtqnkglld sptaveifrk sglnradleq iwnlcdinnt gqlnkqefal 661 gmhlvygkln gkpipnvlps slipsstkll dnlknqlkte ptttkekpsf gkidalsykn 721 ndddvlpnyr nrrkvysakn eeqssfssps aksvnhssst lqtddisvdk tvekktakpk 781 yagfsreinl kniaslenei knisnpency dssipsdlts rfdaiiaklp nlfneistid 841 neitnakiql yrkknpssii gsgpngeite ndrkkaksra llrarmsalt gkstesedsl 901 smedeqqsae ikriqqengk nqeiikdirs sisdisaslk stmtgsnmis nqeferwefg 961 igledgvref lddlksnsnk svtesspfvp sstptpvddr ssspsysqfk taeeraaylk 1021 eqakkrmkek lakfdknrrn vtqssrsiss ensreqpqqi agssnlvepr atpfqeekyv 1081 evaqptqpvq stqpvqptqp vqptqpvqpt qpvqptqpvq ptqpvqnvyn akqesddede 1141 ddeekrlqee lkrlklkkka dkekrlaalr kqiedaqnes deeetngkdn fgghvnvpqa 1201 apvapsaafs qnstnaprsv haavtpaagk nstglpsttm ghnpyfkdas asststfdar 1261 aaemqrriqr gldededdgw sdedesnnrv avdnkveeak ighpdharap pvtaaplpsv 1321 tpvppavpvp qantsnekss pipiapipps vtqeppvpla pplpavdgfq eppipsapai 1381 atavqksgss tpalaggvlp pppplptqqa stsepiiahv dnyngaekgt gaygsdsddd 1441 vlsipesvgt deeeegaqpv stagipsipp agippppplp // LOCUS NP_012272 764 aa linear PLN 30-JUN-2025 DEFINITION hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012272 VERSION NP_012272.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179529.3 REFERENCE 1 (residues 1 to 764) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 764) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 764) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 764) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08553. On Jul 30, 2012 this sequence version replaced NP_012272.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..764 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..764 /product="hydrolase" /calculated_mol_wt="86848" Region 71..>138 /region_name="BglC" /note="Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism]; COG2730" /db_xref="CDD:442036" Region 654..738 /region_name="Glyco_hydro_5_C" /note="Glycoside hydrolase family 5 C-terminal domain; pfam18564" /db_xref="CDD:436581" CDS 1..764 /gene="EGH1" /locus_tag="YIR007W" /coded_by="NM_001179529.3:1..2295" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26116408]" /experiment="EXISTENCE:direct assay:GO:0050295 steryl-beta-glucosidase activity [PMID:26116408]" /experiment="EXISTENCE:mutant phenotype:GO:1904462 ergosteryl 3-beta-D-glucoside catabolic process [PMID:26116408]" /note="Steryl-beta-glucosidase with broad specificity for aglycones; has a role in ergosteryl-beta-glucoside catabolism; required for normal vacuolar morphology; has similarity to the C. neoformans ergosteryl-beta-glucosidase EGCrP2; localizes to the cytosol" /db_xref="GeneID:854824" /db_xref="SGD:S000001446" ORIGIN 1 mpakihisad gqfcdkdgne iqlrgvnldp svkipakpfl sthapiendt ffedadkvsf 61 inhplvlddi eqhiirlksl gyntirlpft weslehagpg qydfdymdyi vevltrinsv 121 qqgmyiyldp hqdvwsrfsg gsgaplwtly cagfqpanfl atdaailhny yidpktgrev 181 gkdeesypkm vwptnyfkla cqtmftlffg gkqyapkcti ngeniqdylq grfndaimtl 241 carikekape lfesnciigl esmnepncgy igetnldvip kernlklgkt ptafqsfmlg 301 egiectidqy krtffgfskg kpctinpkgk kawlsaeerd aidakynwer npewkpdtci 361 wklhgvweiq ngkrpvllkp nyfsqpdatv finnhfvdyy tgiynkfref dqelfiiiqp 421 pvmkpppnlq nskildnrti cachfydgmt lmyktwnkri gidtyglvnk kysnpafavv 481 lgennirkci rkqlsemqkd aksmlgkkvp vffteigipf dmddkkayit ndyssqtaal 541 dalgfalegs nlsytlwcyc sinshiwgdn wnnedfsiws pddkplyhdt raktptpeps 601 pastvasvst stsksgssqp psfikpdnhl dldspsctlk sdlsgfrald aimrpfpiqi 661 hgrfefaefn lcnksyllkl vgkttpeqit vptyifiprh hftpsrlsir sssghytynt 721 dyqvlewfhe pghqfieica ksksrpntpg sdtsndlpae cvis // LOCUS NP_012273 409 aa linear PLN 30-JUN-2025 DEFINITION DNA primase subunit PRI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012273 VERSION NP_012273.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179530.1 REFERENCE 1 (residues 1 to 409) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 409) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 409) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 409) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08554. Method: conceptual translation. FEATURES Location/Qualifiers source 1..409 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..409 /product="DNA primase subunit PRI1" /calculated_mol_wt="47559" Region 13..362 /region_name="primase_sml" /note="DNA primase, eukaryotic-type, small subunit, putative; TIGR00335" /db_xref="CDD:273020" Site order(111,113,115,162,165..166,168,314,323..324,326,332) /site_type="other" /note="nucleotide binding site [chemical binding]" /db_xref="CDD:240130" Site order(130,133) /site_type="other" /note="zinc binding site [ion binding]" /db_xref="CDD:240130" Site order(150..152,190,195,210,213) /site_type="other" /note="subunit interface [polypeptide binding]" /db_xref="CDD:240130" CDS 1..409 /gene="PRI1" /locus_tag="YIR008C" /coded_by="NM_001179530.1:1..1230" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:20404922]" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:2644256|PMID:3888995|PMID:3061469]" /experiment="EXISTENCE:direct assay:GO:0005658 alpha DNA polymerase:primase complex [PMID:3888995|PMID:22593576]" /experiment="EXISTENCE:direct assay:GO:0006269 DNA replication, synthesis of primer [PMID:2644256]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]" /experiment="EXISTENCE:genetic interaction:GO:0003899 DNA-directed RNA polymerase activity [PMID:8436268]" /experiment="EXISTENCE:mutant phenotype:GO:0003899 DNA-directed RNA polymerase activity [PMID:8436268]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:2023935]" /note="Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair" /db_xref="GeneID:854825" /db_xref="SGD:S000001447" ORIGIN 1 mtnsvktngp sssdmeyyyk slypfkhifn wlnhspkpsr dminrefama frsgaykryn 61 sfnsvqdfka qiekanpdrf eigaiynkpp rerdtllkse lkalekelvf didmddydaf 121 rtccsgaqvc skcwkfisla mkitntalre dfgykdfiwv fsgrrgahcw vsdkraralt 181 dvqrrnvldy vnvirdrntd krlalkrpyh phlarsleql kpffvsimle eqnpweddqh 241 aiqtllpaly dkqlidslkk ywldnprrss kekwndidqi atslfkgpkq dshiiklrec 301 kedlvlmtly pkldvevtkq tihllkapfc ihpatgnvcv pidesfapek apklidlqte 361 meknndvslt alqpfinqfq ayvssllkne lgsvkrered ddepasldf // LOCUS NP_012274 111 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit MSL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012274 VERSION NP_012274.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179531.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08555. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..111 /product="U2 snRNP complex subunit MSL1" /calculated_mol_wt="12699" Region 29..105 /region_name="RRM1_U1A_like" /note="RNA recognition motif 1 (RRM1) found in the U1A/U2B'/SNF protein family; cd12246" /db_xref="CDD:409692" Site order(31,33..34,37,62,64,66..67,69..71,73,97,100,102..105) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:409692" CDS 1..111 /gene="MSL1" /locus_tag="YIR009W" /gene_synonym="YIB9" /coded_by="NM_001179531.1:1..336" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9799242]" /experiment="EXISTENCE:physical interaction:GO:0030620 U2 snRNA binding [PMID:8649387]" /note="U2B component of U2 snRNP; involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members" /db_xref="GeneID:854826" /db_xref="SGD:S000001448" ORIGIN 1 mveparkkqr idrdthhtva epvteakntl yvsqlnekin mqrlrvnlfl lfatfgevlk 61 vsmnfkkqrg qafitmrtid qaslaqisln gerffgkplk vefsksetkt l // LOCUS NP_012275 576 aa linear PLN 30-JUN-2025 DEFINITION MIND complex subunit DSN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012275 VERSION NP_012275.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179532.3 REFERENCE 1 (residues 1 to 576) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 576) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 576) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 576) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08556. On Jul 30, 2012 this sequence version replaced NP_012275.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..576 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..576 /product="MIND complex subunit DSN1" /calculated_mol_wt="65561" Region 221..569 /region_name="MIS13" /note="Mis12-Mtw1 protein family; pfam08202" /db_xref="CDD:369747" CDS 1..576 /gene="DSN1" /locus_tag="YIR010W" /coded_by="NM_001179532.3:1..1731" /experiment="EXISTENCE:direct assay:GO:0000444 MIS12/MIND type complex [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:24402315|PMID:14657030]" /experiment="EXISTENCE:direct assay:GO:0000922 spindle pole [PMID:12455957]" /experiment="EXISTENCE:direct assay:GO:0007059 chromosome segregation [PMID:12455957]" /experiment="EXISTENCE:genetic interaction:GO:0051455 spindle attachment to meiosis I kinetochore [PMID:23861669]" /note="Essential component of the outer kinetochore MIND complex; joins kinetochore subunits contacting DNA to those contacting microtubules; phosphorylation promotes interaction between outer and inner kinetochore proteins; kinetochore receptor for monopolin, via interaction with Csm1p; essential for both meiotic and mitotic chromosome segregation; MIND complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; phosphorylated by monopolin subunit, Hrr25p and Aurora kinase, Ipl1p; modified by sumoylation" /db_xref="GeneID:854827" /db_xref="SGD:S000001449" ORIGIN 1 msleptqtvs gtppmlhqrt hkqvyplrme tipilesdsk atlqsneptq kdeeeteyfe 61 nkqsvsnlsp dlkfkrhknk hiqgfptlge rldnlqdikk akrvenfnss apiaddnhsg 121 datanatana tanatanvna sampapympy yyyyhpmnap tpamipypgs pmhsimpnss 181 lqpfysqpta aggpdmttpq nisssqqllp apqlfpygsf hqqqlqqphy iqrtrerkks 241 igsqrgrrls mlasqanggs tiisphkdip eedfytvvgn asfgknlqir qlfnwclmrs 301 lhklelkakn qeeegelehl tkksklestk aetdyvdpkr lamviikefv ddlkkdhiai 361 dwedeekyed edeekildnt enyddtelrq lfqenddddd dddevdysei qrsrrkfser 421 rkalpkepkk llpnsknven tknlsiltsk vnaiknevke wavtldtsrp dlewqeltsf 481 ssqpleplsd teepdlaiad vetkletkvd elryqshiln shslalneit nskvnklnie 541 tmrkissetd ddhsqvinpq qllkglslsf skkldl // LOCUS NP_012276 319 aa linear PLN 30-JUN-2025 DEFINITION Sts1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012276 VERSION NP_012276.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179533.1 REFERENCE 1 (residues 1 to 319) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 319) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 319) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 319) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08557. Method: conceptual translation. FEATURES Location/Qualifiers source 1..319 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..319 /product="Sts1p" /calculated_mol_wt="36354" Region 63..274 /region_name="Cut8" /note="nuclear proteasome tether protein; pfam08559" /db_xref="CDD:462518" CDS 1..319 /gene="STS1" /locus_tag="YIR011C" /gene_synonym="DBF8; SSM5" /coded_by="NM_001179533.1:1..960" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10913188]" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:17916559]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:8065366]" /experiment="EXISTENCE:mutant phenotype:GO:0031144 proteasome localization [PMID:21075847]" /experiment="EXISTENCE:mutant phenotype:GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system [PMID:21075847]" /note="Karyopherin adaptor required for nuclear translocation of the proteasome; mediates interaction between nuclear import factor Srp1p and the proteasome; nuclear import of the 26S proteasome is coupled to RanGTP-initiated, ubiquitin-independent proteasomal degradation of Sts1p; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; role in ubiquitin-mediated protein degradation; contains a bipartite nuclear localization sequence" /db_xref="GeneID:854828" /db_xref="SGD:S000001450" ORIGIN 1 mmgfewgfkp sskitqstvs sqgtgnvmip tagvkqkrry aneeqeeeel prnknvmkyg 61 gvskrrpqpg slirgqplpl qrgmelmnkn qlqqllvdlm tkhpeiqqsv htrvigldfs 121 iqkcldmlkq kseavyqsip ynrsyesnkl ddyafvrmkp qileflnclv dfildnippr 181 lenlhaslkf ldictelvik lprfelasnn yyydkcieql shvwctlieh vardriilla 241 dnssvwkshm trlqvynehs ngllerplql fksldmgsps aassstlslq esiiyhhdtm 301 tanennnnsg saatdspfn // LOCUS NP_012277 431 aa linear PLN 30-JUN-2025 DEFINITION Sqt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012277 VERSION NP_012277.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179534.1 REFERENCE 1 (residues 1 to 431) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 431) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 431) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 431) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08558. Method: conceptual translation. FEATURES Location/Qualifiers source 1..431 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..431 /product="Sqt1p" /calculated_mol_wt="47036" Region 57..395 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(64,82,86,92..93,107..108,126,130,145..146,173..174, 222,227,233..234,252,275,280,286..287,305..306,328,332, 338..339,351,367,371,377..378,390..391) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 68..107 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 113..162 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 179..245 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 257..307 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 314..350 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 355..391 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..431 /gene="SQT1" /locus_tag="YIR012W" /coded_by="NM_001179534.1:1..1296" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9271392]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:26112308]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:9271392]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:26112308]" /note="Specific assembly chaperone for ribosomal protein Rpl10p; co-translationally associates with nascent Rpl10p, preventing aggregation; involved in biogenesis of the ribosomal large subunit; contains multiple WD repeats; interacts genetically and physically with Qsr1p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854829" /db_xref="SGD:S000001451" ORIGIN 1 mepqeefitt eeveqeivpt veveqdvpvd iegendddde mmnddeeale vdmsnnslty 61 fdkhtdsvfa ighhpnlplv ctgggdnlah lwtshsqppk fagtltgyge sviscsftse 121 ggflvtadms gkvlvhmgqk ggaqwklasq mqeveeivwl kthptiartf afgatdgsvw 181 cyqineqdgs leqlmsgfvh qqdcsmgefi ntdkgentle lvtcsldsti vawncftgqq 241 lfkitqaeik gleapwisls lapetltkgn sgvvacgsnn gllavincnn ggailhlstv 301 ielkpeqdel dasiesisws skfslmaigl vcgeillydt sawrvrhkfv ledsvtklmf 361 dnddlfasci ngkvyqfnar tgqekfvcvg hnmgvldfil lhpvantgte qkrkvitagd 421 egvslvfevp n // LOCUS NP_012278 121 aa linear PLN 30-JUN-2025 DEFINITION Gat4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012278 VERSION NP_012278.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179535.3 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08559. On Jul 30, 2012 this sequence version replaced NP_012278.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..121 /product="Gat4p" /calculated_mol_wt="13114" Region 52..108 /region_name="ZnF_GATA" /note="Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C; cd00202" /db_xref="CDD:238123" Site order(53,56,76,79) /site_type="other" /note="zinc binding site [ion binding]" /db_xref="CDD:238123" Site order(62..63,66,76..85,88,105,107..108) /site_type="DNA binding" /note="DNA-binding region [nucleotide binding]" /db_xref="CDD:238123" CDS 1..121 /gene="GAT4" /locus_tag="YIR013C" /coded_by="NM_001179535.3:1..366" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0034224 cellular response to zinc ion starvation [PMID:10392447]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10392447]" /note="Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT3, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants" /db_xref="GeneID:854830" /db_xref="SGD:S000001452" ORIGIN 1 mstklpivis ngtafkkvpv qlllnsgsea qhglprnads qparprtgit rtcgqcgeik 61 tslqwregpn gaaclcnacg lffrklilrf graaakryme qikgtgtkrr ipkeltgtvr 121 f // LOCUS NP_012279 242 aa linear PLN 30-JUN-2025 DEFINITION Vld1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012279 VERSION NP_012279.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179536.3 REFERENCE 1 (residues 1 to 242) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 242) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 242) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 242) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08560. On Jul 30, 2012 this sequence version replaced NP_012279.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..242 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..242 /product="Vld1p" /calculated_mol_wt="27469" CDS 1..242 /gene="VLD1" /locus_tag="YIR014W" /coded_by="NM_001179536.3:1..729" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:29355480]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0044695 Dsc E3 ubiquitin ligase complex [PMID:29355480]" /note="Trafficking adaptor for the Dsc E3 ligase complex; component of a Dsc subcomplex that diverts the E3 ligase via the AP-3 pathway directly to the limiting membrane of the vacuole; involved in the endosome and Golgi-associated degradation pathway (EGAD), contributing to proteostasis and lipid homeostasis; localizes to the vacuole; localizes to the ER in high-throughput studies; expression is directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; non-essential gene" /db_xref="GeneID:854831" /db_xref="SGD:S000001453" ORIGIN 1 mlhleddngr qrsvianlqk fvycclylrf ikdgslflil lgwiisslcd fiqeltlryl 61 kknylevgrd ndqeddesla irgletpivr miinkairyy qglilletay civyhirldv 121 srdicskpyg fvimlliref tcpvptafps klllvlldil llfcqiviin gslssslqnv 181 klivkelnae eegalnilkl ntwhmdatgp elivlknhdk sipqqadgdd ateitpllni 241 ae // LOCUS NP_012280 144 aa linear PLN 30-JUN-2025 DEFINITION ribonuclease P protein subunit RPR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012280 VERSION NP_012280.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179537.1 REFERENCE 1 (residues 1 to 144) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 144) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 144) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 144) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08561. Method: conceptual translation. FEATURES Location/Qualifiers source 1..144 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..144 /product="ribonuclease P protein subunit RPR2" /EC_number="3.1.26.5" /calculated_mol_wt="16213" Region 36..>97 /region_name="Rpr2" /note="RNAse P Rpr2/Rpp21/SNM1 subunit domain; pfam04032" /db_xref="CDD:427665" CDS 1..144 /gene="RPR2" /locus_tag="YIR015W" /coded_by="NM_001179537.1:1..435" /experiment="EXISTENCE:direct assay:GO:0004526 ribonuclease P activity [PMID:19095620]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:19095620|PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9620854]" /note="Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; increases the activity and thermal stability of the complex, along with Pop2p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854832" /db_xref="SGD:S000001454" ORIGIN 1 mgkkahggkm kpeidengtl lvppprtian qdhfhrlnyl yqisayqtra rqkartdaht 61 plarnyiksm dliskktkts llptikrtic kkchrllwtp kkleitsdga lsvmcgcgtv 121 krfnigadpn yrtyseregn llns // LOCUS NP_012281 265 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIR016W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012281 VERSION NP_012281.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179538.1 REFERENCE 1 (residues 1 to 265) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 265) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 265) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 265) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08562. Method: conceptual translation. FEATURES Location/Qualifiers source 1..265 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..265 /product="uncharacterized protein" /calculated_mol_wt="28751" CDS 1..265 /locus_tag="YIR016W" /coded_by="NM_001179538.1:1..798" /note="hypothetical protein; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; non-essential gene; YIR016W has a paralog, YOL036W, that arose from the whole genome duplication" /db_xref="GeneID:854833" /db_xref="SGD:S000001455" ORIGIN 1 msgtrcllgv glpvdvtate tlthdeqgpg vepgpcsrgs sidgllpsll gphddvddds 61 aafhkymtls rdgagaihap slvedasrnd dddddedddd ssmsrdlska ldmsssssss 121 prvqsrrhrs svsaisailh qgksgredit gslsvpaeqe klsflakass iffrrnsmpr 181 dkhthsvcpa srpdserfiv tsaaaqslrr qqqledaqya rvitnfrtig wcspseiesv 241 eykrslinae wdekisllsh aqcyk // LOCUS NP_012282 187 aa linear PLN 30-JUN-2025 DEFINITION Met28p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012282 VERSION NP_012282.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179539.3 REFERENCE 1 (residues 1 to 187) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 187) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 187) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 187) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08563. On Jul 30, 2012 this sequence version replaced NP_012282.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..187 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..187 /product="Met28p" /calculated_mol_wt="21459" Region 109..162 /region_name="bZIP_Zip1" /note="Basic leucine zipper (bZIP) domain of Fungal Zip1-like transcription factors: a DNA-binding and dimerization domain; cd14705" /db_xref="CDD:269853" Region 109..161 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269853" Site order(111..112,114..116,118..123,125..127) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269853" Site order(126,129..130,133..134,136..137,140..141,143..144, 147..148,150..151,154..155,157..158) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269853" CDS 1..187 /gene="MET28" /locus_tag="YIR017C" /coded_by="NM_001179539.3:1..564" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:8665859]" /experiment="EXISTENCE:direct assay:GO:0089713 Cbf1-Met4-Met28 complex [PMID:8665859|PMID:9171357]" /experiment="EXISTENCE:direct assay:GO:2000679 positive regulation of transcription regulatory region DNA binding [PMID:9171357]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:8665859]" /experiment="EXISTENCE:mutant phenotype:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:8665859]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:8665859]" /note="bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex; participates in the regulation of sulfur metabolism" /db_xref="GeneID:854834" /db_xref="SGD:S000001456" ORIGIN 1 msakqgwekk stnidiasrk gmnvnnlseh lqnlissdse lgsrllslll vssgnaeeli 61 sminngqdvs qfkklreprk gkvaattavv vkeeeapvst sneldkikqe rrrknteasq 121 rfrirkkqkn fenmnklqnl ntqinklrdr ieqlnkenef wkaklndine ikslkllndi 181 krrnmgr // LOCUS NP_012283 245 aa linear PLN 30-JUN-2025 DEFINITION Yap5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012283 VERSION NP_012283.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179540.1 REFERENCE 1 (residues 1 to 245) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 245) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 245) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 245) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08564. Method: conceptual translation. FEATURES Location/Qualifiers source 1..245 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..245 /product="Yap5p" /calculated_mol_wt="28255" Region 59..121 /region_name="bZIP_YAP" /note="Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain; cd14688" /db_xref="CDD:269836" Site order(59..60,64..65,67..69,71..72,75..76,78..79) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269836" Region 63..121 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269836" Site order(82..83,86..87,89..90,93..94,96..97,100,103..104, 107..108,111,114..115,117..118) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269836" CDS 1..245 /gene="YAP5" /locus_tag="YIR018W" /coded_by="NM_001179540.1:1..738" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:18287073]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18070921]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9372930]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18287073]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:18287073|PMID:18070921]" /experiment="EXISTENCE:mutant phenotype:GO:0071281 cellular response to iron ion [PMID:18070921]" /note="Basic leucine zipper (bZIP) iron-sensing transcription factor; senses high-iron conditions via two Fe/S clusters bound to its activator domain; involved in diauxic shift; YAP5 has a paralog, YAP7, that arose from the whole genome duplication" /db_xref="GeneID:854835" /db_xref="SGD:S000001457" ORIGIN 1 malplikpke seeshlalls kihvsknwkl pprlphraaq rrkrvhrlhe dyeteendee 61 lqkkkrqnrd aqrayrerkn nklqvleeti eslskvvkny etklnrlqne lqakesenha 121 lkqkletltl kqasvpaqdp ilqnlienfk pmkaipikyn taikrhqhst elpssvkcgf 181 cndnttcvck eletdhrksd dgvateqkdm smphaecnnk dnpnglcsnc tnidkscidi 241 rsiih // LOCUS NP_878099 45 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIR018C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878099 VERSION NP_878099.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184655.1 REFERENCE 1 (residues 1 to 45) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 45) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 45) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 45) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 45) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 45) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 45) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08565. Method: conceptual translation. FEATURES Location/Qualifiers source 1..45 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..45 /product="uncharacterized protein" /calculated_mol_wt="5087" CDS 1..45 /locus_tag="YIR018C-A" /coded_by="NM_001184655.1:1..138" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466494" /db_xref="SGD:S000028837" ORIGIN 1 mpsdytshyp vilikkkkkk iagmyrhskr yleimstasa qfvgn // LOCUS NP_012284 1367 aa linear PLN 30-JUN-2025 DEFINITION Flo11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012284 VERSION NP_012284.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179541.3 REFERENCE 1 (residues 1 to 1367) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1367) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1367) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1367) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08566. On Jul 30, 2012 this sequence version replaced NP_012284.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1367 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1367 /product="Flo11p" /calculated_mol_wt="135980" Region 43..193 /region_name="Flo11" /note="Flo11 domain; pfam10182" /db_xref="CDD:401990" Region 1068..>1269 /region_name="Chi1" /note="Chitinase [Carbohydrate transport and metabolism]; COG3469" /db_xref="CDD:442692" CDS 1..1367 /gene="FLO11" /locus_tag="YIR019C" /gene_synonym="MUC1; STA4" /coded_by="NM_001179541.3:1..4104" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:20619652]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11027318]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:19799621]" /experiment="EXISTENCE:direct assay:GO:0030447 filamentous growth [PMID:12072450]" /experiment="EXISTENCE:mutant phenotype:GO:0000128 flocculation [PMID:19160455]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:19087208|PMID:8710886|PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:8710886]" /experiment="EXISTENCE:mutant phenotype:GO:0043709 cell adhesion involved in single-species biofilm formation [PMID:11157168]" /experiment="EXISTENCE:mutant phenotype:GO:0090606 single-species surface biofilm formation [PMID:19160455|PMID:12024013]" /experiment="EXISTENCE:mutant phenotype:GO:0098609 cell-cell adhesion [PMID:19160455|PMID:21875945]" /note="GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal and invasive growth, flocculation, and biofilm formation; major determinant of colony morphology; QTL that controls chronological life span; carries intragenic tandem repeats that are expanded in different strains; required for formation of fibrous interconnections between cells; role in co-flocculation with other yeast species; cleaved and shed from cells, contributing to their surface properties" /db_xref="GeneID:854836" /db_xref="SGD:S000001458" ORIGIN 1 mqrpfllayl vlsllfnsal gfptalvprg ssegtscnsi vngcpnldfn whmdqqnimq 61 ytldvtsvsw vqdntyqiti hvkgkenidl kylwslkiig vtgpkgtvql ygynentyli 121 dnptdftatf evyatqdvns cqvwmpnfqi qfeylqgsaa qyasswqwgt tsfdlstgcn 181 nydnqghsqt dfpgfywnid cdnncggtks stttsstses stttsstses stttsstses 241 stttsstses stsssttapa tptttsctke kptpptttsc tkekptpphh dttpctkkkt 301 ttsktctkkt ttpvptpsss ttesssapvp tpsssttess sapvtsstte sssapvptps 361 ssttesssap vtssttesss apvtssttes ssapvptpss sttesssapv tssttesssa 421 pvtssttess sapvtsstte sssapvtsst tesssapvpt psssttesss apvtssttes 481 ssapvptpss sttesssapv tssttesssa pvptpssstt esssapaptp sssttesssa 541 pvtssttess sapvptpsss ttessstpvt ssttesssap vptpssstte sssapvptps 601 ssttesssap aptpssstte sssapvtsst tesssapvpt psssttesss apvptpssst 661 tesssapvpt psssttesss apvtssttes ssapvtsstt esssapvptp sssttesssa 721 pvptpssstt esssapvptp sssttesssa pvtssttess sapvptpsss ttesssapvp 781 tpsssttess sapvptpsss ttessvapvp tpssssnits sapsstpfss stesssvpvp 841 tpsssttess sapvssstte ssvapvptps sssnitssap ssipfsstte sfstgttvtp 901 ssskypgsqt etsvssttet tivptkttts vttpstttit ttvcstgtns agettsgcsp 961 ktvtttvptt tttsvttsst ttitttvcst gtnsagetts gcspktittt vpcstspset 1021 asestttspt tpvttvvstt vvtteystst kpggeitttf vtknipttyl ttiaptpsvt 1081 tvtnftptti tttvcstgtn sagettsgcs pktvtttvpc stgtgeytte attlvttavt 1141 ttvvttesst gtnsagkttt gyttksvptt yvttlapsap vtpatnavpt titttecsaa 1201 tnaagettsv csaktivssa sagentapsa ttpvttaipt tvittessvg tnsagetttg 1261 yttksiptty ittlipgsng aknyetvata tnpisiktts qlattasass vapvvtspsl 1321 tgplqsasgs avatysvpsi sstyqgaani kvlgnfmwll lalpvvf // LOCUS NP_001257681 100 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIR020C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257681 VERSION NP_001257681.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270752.1 REFERENCE 1 (residues 1 to 100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 100) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35119. Method: conceptual translation. FEATURES Location/Qualifiers source 1..100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..100 /product="uncharacterized protein" /calculated_mol_wt="11541" CDS 1..100 /locus_tag="YIR020C" /coded_by="NM_001270752.1:1..303" /note="hypothetical protein; mRNA identified as translated by ribosome profiling data; SWAT-GFP fusion protein localizes to the endoplasmic reticulum" /db_xref="GeneID:854837" /db_xref="SGD:S000001459" ORIGIN 1 mtfflkrkis fflsgiaqtf lflpillnrs vihvvfltvv lghripwdsv ircnntgtth 61 savssrtell lpiggvinnw krrawngfsi qwiwrysfvy // LOCUS NP_012287 363 aa linear PLN 30-JUN-2025 DEFINITION Mrs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012287 VERSION NP_012287.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179543.3 REFERENCE 1 (residues 1 to 363) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 363) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 363) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 363) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08567. On Jul 30, 2012 this sequence version replaced NP_012287.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..363 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..363 /product="Mrs1p" /calculated_mol_wt="41159" Site order(79,105,151..153,164) /site_type="other" /note="nucleic acid substrate binding site [nucleotide binding]" /db_xref="CDD:438563" Region 83..357 /region_name="Ydc2-catalyt" /note="Mitochondrial resolvase Ydc2 / RNA splicing MRS1; pfam09159" /db_xref="CDD:401193" Site order(129,165..166,168..170,172..173) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:438563" CDS 1..363 /gene="MRS1" /locus_tag="YIR021W" /gene_synonym="PET157" /coded_by="NM_001179543.3:1..1092" /experiment="EXISTENCE:direct assay:GO:0000372 Group I intron splicing [PMID:11773622]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:11773622]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:14562095|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:1990904 ribonucleoprotein complex [PMID:12924947]" /experiment="EXISTENCE:mutant phenotype:GO:0000963 mitochondrial RNA processing [PMID:2443348]" /note="Splicing protein; required for splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA; MRS1 has a paralog, CCE1, that arose from the whole genome duplication" /db_xref="GeneID:854839" /db_xref="SGD:S000001460" ORIGIN 1 mspknitrsv ipaidlycrk anfktlksls milgskkewy dtkkaplrtf lvsrcgifeq 61 lrgrlvedgk vnlfsvfltn dsfsfckmtv ddkfntslvd wqkipfdstf atdrrqnisl 121 lpvdtlfate kiisilgvsp nmtnlvsier ersdlvdfnc klqsnilehl lyakcqgvyv 181 tstnekarll aavcnpefid tfwceltpir vslkenpsis vpreyqmydp vvratikevv 241 tkrllrsafd ndidplmclh ldkgwklkfp ilssttglnf slkdclsldt gkdasdmtev 301 flatmesskv lrtysnlvdi vmkdngrlds gvlkqfndyv kqeklnlqhf qagsskflkg 361 aki // LOCUS NP_878100 70 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIR021W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878100 VERSION NP_878100.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184656.1 REFERENCE 1 (residues 1 to 70) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 70) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 70) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 70) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08568. Method: conceptual translation. FEATURES Location/Qualifiers source 1..70 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..70 /product="uncharacterized protein" /calculated_mol_wt="7549" CDS 1..70 /locus_tag="YIR021W-A" /coded_by="NM_001184656.1:1..213" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466495" /db_xref="SGD:S000028838" ORIGIN 1 msfsvscktp kttkllvssi sesavaliii tirilfsigk sdfkkiiske ingaetiyyr 61 nipeskpqgs // LOCUS NP_012288 167 aa linear PLN 30-JUN-2025 DEFINITION signal peptidase complex catalytic subunit SEC11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012288 VERSION NP_012288.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179544.1 REFERENCE 1 (residues 1 to 167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 167) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08569. Method: conceptual translation. FEATURES Location/Qualifiers source 1..167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..167 /product="signal peptidase complex catalytic subunit SEC11" /EC_number="3.4.21.89" /calculated_mol_wt="18631" Region 26..146 /region_name="Peptidase_S24_S26" /note="The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; cl10465" /db_xref="CDD:447902" Site order(44,83) /site_type="active" /note="Catalytic site [active]" /db_xref="CDD:119396" CDS 1..167 /gene="SEC11" /locus_tag="YIR022W" /coded_by="NM_001179544.1:1..504" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11058593]" /experiment="EXISTENCE:direct assay:GO:0005787 signal peptidase complex [PMID:1846444|PMID:8910564]" /experiment="EXISTENCE:direct assay:GO:0006465 signal peptide processing [PMID:10206957]" /experiment="EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:10206957|PMID:3283143]" /experiment="EXISTENCE:mutant phenotype:GO:0008233 peptidase activity [PMID:10206957]" /experiment="EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:3283143]" /note="18kDa catalytic subunit of the Signal Peptidase Complex (SPC); the Signal Peptidase Complex cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; other members are Spc1p, Spc2p, Spc3p, and Sec11p" /db_xref="GeneID:854840" /db_xref="SGD:S000001461" ORIGIN 1 mnlrfelqkl lnvcflfasa ymfwqglaia tnsaspivvv lsgsmepafq rgdilflwnr 61 ntfnqvgdvv vyevegkqip ivhrvlrqhn nhadkqfllt kgdnnagndi slyankkiyl 121 nkskeivgtv kgyfpqlgyi tiwisenkya kfallgmlgl sallgge // LOCUS NP_012289 970 aa linear PLN 30-JUN-2025 DEFINITION Dal81p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012289 VERSION NP_012289.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179545.3 REFERENCE 1 (residues 1 to 970) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 970) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 970) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 970) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 970) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 970) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 970) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08570. On Jul 30, 2012 this sequence version replaced NP_012289.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..970 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..970 /product="Dal81p" /calculated_mol_wt="109044" Region 149..188 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(149,154..157,159,162,174) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(150,153,160,169,172,179) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 319..732 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" Region <729..>963 /region_name="Herpes_BLLF1" /note="Herpes virus major outer envelope glycoprotein (BLLF1); pfam05109" /db_xref="CDD:282904" CDS 1..970 /gene="DAL81" /locus_tag="YIR023W" /gene_synonym="UGA35" /coded_by="NM_001179545.3:1..2913" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:21515579]" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:21515579]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:21515579]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:21515579]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7899074]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:21515579]" /experiment="EXISTENCE:mutant phenotype:GO:1901714 positive regulation of urea catabolic process [PMID:2406136]" /experiment="EXISTENCE:mutant phenotype:GO:1901717 positive regulation of gamma-aminobutyric acid catabolic process [PMID:2406136]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10906145]" /note="Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism" /db_xref="GeneID:854841" /db_xref="SGD:S000001462" ORIGIN 1 mdphqspadn aasptksvka ttknsstnnn vnsnnsnnns nhdilnfndn yttilqhlan 61 dhpnilrekg gsqqqqhqqq qqqqqqqqqq qqqqsldtll hhyqsllsks dnaiafddnv 121 snsadhngsn snnnnnnndi sspgnlmgsc nqcrlkktkc nyfpdlgncl ecetsrtkct 181 fsiapnylkr tssgannnmp tssnskrmkn fedysnrlps smlyrhqqqq qqqqqqqriq 241 yprssffvgp asvfdlnltk hvrldnvdqi qlsktlslrk vsptaqfilq ddfdttlhsk 301 qeyevdlven lvhphghllv eiffklihpf lpilhervfl ekysrsyrel tapllasiys 361 lalqywdfhp allgfpkpdv taqlnniale tfyarvgrpk lsiiqtglli lqcrsechnn 421 wvlcssvval aeelglgvec ndwklpkwek dlrkrlawav wlmdkwcaln egrqshlilg 481 rnwmikllnf ddfplnspti lnslqndqsg sspsssndvk nhqiafgnlp ifninptled 541 fkngtlmfqq mvslsiilge imdtfytqgs mtinksieqv lklakplqlk lrewyhslpk 601 nlsmsyatpq klnsnstltl ayfateitlh rkiicalnpq tpkelvqvcr taartrlvaa 661 iefirdlkne hinafwyncs tgnlmligtf aallyvtsat keeamifrdy vrnytwvlki 721 gskyfdklsn alnnmhllfa qipglltdep vvvspnsnin svnpqrsgvq sqipiqfnvg 781 spamteqgsp lnqwknlpqe ilqqlnsfpn gttstttpvn ptsrqtqles qgspainsan 841 nnsnntplpf apnksskkts qsspnvtpsh msrhppsnts sprvnsstnv nsntqmnasp 901 ltsinetrqe sgdaadekta grertanees stelkddnpn snqetsatgn qtikmnddkn 961 vtintretpl // LOCUS NP_012290 216 aa linear PLN 30-JUN-2025 DEFINITION Ina22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012290 VERSION NP_012290.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179546.1 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08571. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..216 /product="Ina22p" /calculated_mol_wt="24466" CDS 1..216 /gene="INA22" /locus_tag="YIR024C" /coded_by="NM_001179546.1:1..651" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:24942160]" /experiment="EXISTENCE:direct assay:GO:1990524 INA complex [PMID:24942160]" /experiment="EXISTENCE:genetic interaction:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:24942160]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:24942160]" /experiment="EXISTENCE:physical interaction:GO:1990524 INA complex [PMID:24942160]" /note="F1F0 ATP synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Aim43p, ATP synthase subunits, and cytochrome bc1 complex assembly factors; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect" /db_xref="GeneID:854842" /db_xref="SGD:S000001463" ORIGIN 1 mfmarqvlrn glflrslapi kitartvasa nagikrksrf dktmikplll vmifgsilna 61 viaekrniid merkyklkld klkelirrvh dnngkvdfda ddelklvnlr lgivgknatg 121 mkedetdivv pkeesleeiw qsiideakke viektpdagv knkegivtdl nvlkdleksk 181 kedekvylsg dvhmmmnqpg dlneiakehd kipkfl // LOCUS NP_012291 368 aa linear PLN 30-JUN-2025 DEFINITION Mnd2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012291 VERSION NP_012291.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179547.1 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08572. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..368 /product="Mnd2p" /calculated_mol_wt="42695" Region 8..136 /region_name="Apc15p" /note="Apc15p protein; pfam05841" /db_xref="CDD:399091" CDS 1..368 /gene="MND2" /locus_tag="YIR025W" /coded_by="NM_001179547.1:1..1107" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15797380]" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:12609981|PMID:12574115]" /experiment="EXISTENCE:direct assay:GO:0071173 spindle assembly checkpoint signaling [PMID:22940250]" /experiment="EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:22940250]" /experiment="EXISTENCE:direct assay:GO:1990948 ubiquitin ligase inhibitor activity [PMID:15797379]" /experiment="EXISTENCE:genetic interaction:GO:1905785 negative regulation of anaphase-promoting complex-dependent catabolic process [PMID:15797380]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:15797379]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0030071 regulation of mitotic metaphase/anaphase transition [PMID:12609981]" /experiment="EXISTENCE:mutant phenotype:GO:1902426 deactivation of mitotic spindle assembly checkpoint [PMID:22940250]" /experiment="EXISTENCE:mutant phenotype:GO:1902499 positive regulation of protein autoubiquitination [PMID:22940250]" /experiment="EXISTENCE:physical interaction:GO:0005680 anaphase-promoting complex [PMID:15797379]" /note="Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase" /db_xref="GeneID:854843" /db_xref="SGD:S000001464" ORIGIN 1 maralrdisl fndirkdqns agakherynm rdlrskknqh vngiddyedd sldrfirrkk 61 srvvkyipsl saynvfnefp yyptsasqll dgkldeflml seqyksrlpk irklgwnrfk 121 piginktmye lemlrsrara qnaegnneed frqhdsreed prnngsigrv ilphilqene 181 eydtgegvtg lhsmpndsma ilannsanns qneevseede isydydaefd hvvdeddnee 241 gevpgegveg ievqrerivp ddllmrptsl srslqqfvee ahhldrnpyd idsdndgeds 301 kveldmnpdf eddvgrehdy nseysqepts yggitpdlas nwrnwtreri tsldelmerr 361 arqqrgqd // LOCUS NP_012292 364 aa linear PLN 30-JUN-2025 DEFINITION tyrosine protein phosphatase YVH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012292 VERSION NP_012292.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179548.3 REFERENCE 1 (residues 1 to 364) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 364) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 364) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 364) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08573. On Jul 30, 2012 this sequence version replaced NP_012292.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..364 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..364 /product="tyrosine protein phosphatase YVH1" /EC_number="3.1.3.48" /calculated_mol_wt="41054" Region 12..173 /region_name="DSP_fungal_YVH1" /note="dual specificity phosphatase domain of fungal YVH1-like dual specificity protein phosphatase; cd14518" /db_xref="CDD:350368" CDS 1..364 /gene="YVH1" /locus_tag="YIR026C" /coded_by="NM_001179548.3:1..1095" /experiment="EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:1334559]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19797078|PMID:19797079]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19797079|PMID:19797078|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:1990275 preribosome binding [PMID:19797078]" /experiment="EXISTENCE:genetic interaction:GO:0000027 ribosomal large subunit assembly [PMID:19797078]" /experiment="EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:19797079]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:10464190]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:19797078|PMID:19114459]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:19797079]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:26125457]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:26125457]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:10464190]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:8896280]" /experiment="EXISTENCE:mutant phenotype:GO:2000786 positive regulation of autophagosome assembly [PMID:26125457]" /note="Dual specificity protein phosphatase; regulates growth, sporulation, and glycogen accumulation in a cAMP-dependent protein kinase cascade dependent manner; mutants are defective in 60S ribosome assembly; positively regulates pre-autophagosomal structure (PAS) formation upon nitrogen starvation or rapamycin treatment" /db_xref="GeneID:854844" /db_xref="SGD:S000001465" ORIGIN 1 magnansvde evtrilggiy lggirpiidh rplgaefnit hilsvikfqv ipeylirkgy 61 tlknipiddd dvtdvlqyfd etnrfidqcl fpneveyspr lvdfkkkpqr gavfahcqag 121 lsrsvtfiva ylmyryglsl smamhavkrk kpsvepnenf meqlhlfekm ggdfvdfdnp 181 aykqwklkqs ikldpsgsel vsnsgmfkds essqdldklt eaekskvtav rckkcrtkla 241 lstsfiahdp pskesseghf ikraanshri idiqesqanc shffieplkw mqpelqgkqe 301 legkfscpgc sskvggynwk gsrcscgkwv ipaihlqtsk vdqfplqsta lpnmvnfese 361 kvnr // LOCUS NP_012293 460 aa linear PLN 30-JUN-2025 DEFINITION allantoinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012293 VERSION NP_012293.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179549.3 REFERENCE 1 (residues 1 to 460) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 460) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 460) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 460) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08574. On Jul 30, 2012 this sequence version replaced NP_012293.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..460 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..460 /product="allantoinase" /EC_number="3.5.2.5" /calculated_mol_wt="49995" Region 9..456 /region_name="L-HYD_ALN" /note="L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; cd01315" /db_xref="CDD:238640" Site order(70,72,193,250,323) /site_type="active" /db_xref="CDD:238640" CDS 1..460 /gene="DAL1" /locus_tag="YIR027C" /coded_by="NM_001179549.3:1..1383" /experiment="EXISTENCE:mutant phenotype:GO:0004038 allantoinase activity [PMID:4604238|PMID:1803816]" /experiment="EXISTENCE:mutant phenotype:GO:0009442 allantoin assimilation pathway [PMID:4604238|PMID:1803816]" /note="Allantoinase; converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression" /db_xref="GeneID:854845" /db_xref="SGD:S000001466" ORIGIN 1 mpinaitsdh viingankpa tivystesgt ildvlegsvv mekteitkye ihtlenvspc 61 tilpglvdsh vhlnepgrts wegfetgtqa aisggvttvv dmplnaippt tnvenfrikl 121 eaaegqmwcd vgfwgglvph nlpdliplvk agvrgfkgfl ldsgveefpp igkeyieeal 181 kvlaeedtmm mfhaelpkah edqqqpeqsh reyssflssr pdsfeidain lileclrarn 241 gpvppvhivh lasmkaipli rkarasglpv ttetcfhylc iaaeqipdga tyfkccppir 301 sesnrqglwd alregvigsv vsdhspctpe lknlqkgdff dswggiasvg lglplmftqg 361 cslvdivtwc ckntshqvgl shqkgtiapg ydadlvvfdt askhkisnss vyfknkltay 421 ngmtvkgtvl ktilrgqvvy tnangvsktp lgqtlldsrr // LOCUS NP_012294 635 aa linear PLN 30-JUN-2025 DEFINITION allantoin permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_012294 VERSION NP_012294.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179550.3 REFERENCE 1 (residues 1 to 635) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 635) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 635) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 635) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 635) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08575. On Jul 30, 2012 this sequence version replaced NP_012294.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..635 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..635 /product="allantoin permease" /calculated_mol_wt="71625" Region 98..582 /region_name="SLC-NCS1sbd_NRT1-like" /note="nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain; cd11482" /db_xref="CDD:271375" Site order(124,127,414,417..418) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271375" Site order(128,204,208,326..327,329,419,423) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:271375" CDS 1..635 /gene="DAL4" /locus_tag="YIR028W" /coded_by="NM_001179550.3:1..1908" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000256 allantoin catabolic process [PMID:385448]" /experiment="EXISTENCE:mutant phenotype:GO:0005274 allantoin:proton symporter activity [PMID:385448]" /experiment="EXISTENCE:mutant phenotype:GO:0015720 allantoin transport [PMID:385448|PMID:3549700]" /note="Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation" /db_xref="GeneID:854846" /db_xref="SGD:S000001467" ORIGIN 1 mandalsaif snpsrkgvqp stsivsytnn eddiidveng kfnknknint nvyvdnssie 61 esevvplpet ksiwskiyyd fivldkttln vslkesflyn rdlkpveeer rcwswfnyly 121 fwladcfnin twqiagtglq lglnwwqcwl tvwigytfag ifvvlnsrfg sayhlsfpit 181 vrasfgiffs mwpiinrvvm aivwyavqaw lgatpvalml ksifgknled ripnhfgspn 241 sttfefmcff ifwvvsipfv lvaphkirhl ftvkaalipf aafgfliwal kkshgkielg 301 tlndysphgs efswifvrsl macvanfaal iinapdfgrf aknpqaslwp qlvaiplffa 361 itcligiivt aagyhlygvn ywspldvlgq flettytrgt ragvflisfv falaqlgtni 421 sanslacgad mtalfpryin irrgslfcva malcicpwnl massskftsa lgayaiflss 481 iagvicadyf vvrrgyvklt hlflaqkgsf ymfgnkfgan wrafvayicg iapnlpgfig 541 dvgapkitvs egamrlyylg ypvgffisav iylilcyffp vpgtpvtnfl tekgwfqrwa 601 yvedfeqdwk nelrrddlcd dtvsiydgte ekivy // LOCUS NP_012295 343 aa linear PLN 30-JUN-2025 DEFINITION allantoicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012295 VERSION NP_012295.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179551.1 REFERENCE 1 (residues 1 to 343) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 343) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 343) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 343) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08576. Method: conceptual translation. FEATURES Location/Qualifiers source 1..343 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..343 /product="allantoicase" /EC_number="3.5.3.4" /calculated_mol_wt="38583" Region 21..343 /region_name="allantoicase" /note="TIGR02961" /db_xref="CDD:274363" CDS 1..343 /gene="DAL2" /locus_tag="YIR029W" /gene_synonym="ALC1" /coded_by="NM_001179551.1:1..1032" /experiment="EXISTENCE:direct assay:GO:0004037 allantoicase activity [PMID:3915539]" /experiment="EXISTENCE:mutant phenotype:GO:0000256 allantoin catabolic process [PMID:1916277]" /note="Allantoicase; converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation" /db_xref="GeneID:854847" /db_xref="SGD:S000001468" ORIGIN 1 mkffsladea efksiiiskn kavdvigskl ggqvvsfsde wfasaenliq ptapirdptr 61 fvhsgawydg wetrrhneme ydwviikmgv aaahiiggei dtaffngnha pfvsiealyd 121 egeegnived dsrwveivek fecgpsqrhl fvrgngltke rfthiklkmy pdggiarfrl 181 ygrvvppelk tkdhiidlay vcngavalky sdqhfgsvdn lllpgrghdm sdgwetkrsr 241 qpghtdwavi qlgressfie kiivdtahfr gnfpqfitve gclkesesse ntgegtwvel 301 vgksktgpdk ehvyeirksi rvshvkltii pdggvkrirv wgy // LOCUS NP_012296 244 aa linear PLN 30-JUN-2025 DEFINITION Dcg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012296 VERSION NP_012296.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179552.1 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08577. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..244 /product="Dcg1p" /calculated_mol_wt="27182" Region 5..233 /region_name="Asp_Glu_race" /note="Asp/Glu/Hydantoin racemase; pfam01177" /db_xref="CDD:426101" CDS 1..244 /gene="DCG1" /locus_tag="YIR030C" /coded_by="NM_001179552.1:1..735" /experiment="EXISTENCE:expression pattern:GO:0008152 metabolic process [PMID:1916277]" /note="hypothetical protein; expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain" /db_xref="GeneID:854848" /db_xref="SGD:S000001469" ORIGIN 1 metrilvvnp nssksmtvsl retiektfsm esckisyftg pdtsppqidg qetsiksmea 61 clplliddqe svyyfqkfng iliacfsdhp lvakikdraa kekadvsivg lldssinycn 121 lvgkkfsiit snkewipiln nsveskfltg ntvnknlwkg tvstdlqvld lhspenfqqi 181 aeiiyrenik kldsdivilg cagfsglqnk laktfqrdgt lfldtieigl qilitmirfv 241 nsqk // LOCUS NP_012297 554 aa linear PLN 30-JUN-2025 DEFINITION malate synthase DAL7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012297 VERSION NP_012297.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179553.3 REFERENCE 1 (residues 1 to 554) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 554) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 554) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08578. On Jul 30, 2012 this sequence version replaced NP_012297.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..554 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..554 /product="malate synthase DAL7" /EC_number="2.3.3.9" /calculated_mol_wt="62663" Region 31..542 /region_name="malate_syn_A" /note="malate synthase A; TIGR01344" /db_xref="CDD:188132" Site order(177,261,287,289,457) /site_type="active" /db_xref="CDD:238369" CDS 1..554 /gene="DAL7" /locus_tag="YIR031C" /gene_synonym="MLS2; MSL2" /coded_by="NM_001179553.3:1..1665" /experiment="EXISTENCE:direct assay:GO:0000256 allantoin catabolic process [PMID:8462696]" /experiment="EXISTENCE:direct assay:GO:0004474 malate synthase activity [PMID:8462696]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27678487]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0004474 malate synthase activity [PMID:23642236]" /note="Malate synthase; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA; recycles glyoxylate generated during allantoin degradation; SWAT-GFP and mCherry fusion proteins localize to the cytosol; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation" /db_xref="GeneID:854849" /db_xref="SGD:S000001470" ORIGIN 1 mvkisldnta lyadidttpq fepskttvad iltkdalefi vllhrtfnst rkqllanrsn 61 lqskldsgey rfdflpeteq irndptwqga ipapglinrs seitgpplrn mlvnalnaev 121 ttymtdfeds ssptwenmiy gqvnlydair nqidfktprk eyrlkddisr lptlivrprg 181 whmvekhlyi ddepisasif dfglyfyhna kelvkigkgp yfylpkmehh mevklwndif 241 cvaqdfigmp rgtiratvli etlpaafqme eiiyqirehs sglncgrwdy ifstikklrn 301 lpehvlpnrd lvtmtspfmd ayvkrlintc hrrgvhamgg maaqipikdd pkaneaamnk 361 vrndkiremk nghdgswvah palapicnev fsnmgtanqi yfvpdvhvts sdllntkiqd 421 aqvttegirv nldiglqyme awlrgsgcvp inhlmedaat aevsrcqlyq wvkhgvvlsd 481 tgdkvtpelt akilneetak lasasplgek nkfalaakyf lpevtgkifs dflttllyde 541 iikpsakpvd lskl // LOCUS NP_012298 195 aa linear PLN 30-JUN-2025 DEFINITION ureidoglycolate hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012298 VERSION NP_012298.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179554.1 REFERENCE 1 (residues 1 to 195) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 195) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 195) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 195) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08579. Method: conceptual translation. FEATURES Location/Qualifiers source 1..195 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..195 /product="ureidoglycolate hydrolase" /EC_number="4.3.2.3" /calculated_mol_wt="21596" Region 1..186 /region_name="Ureidogly_lyase" /note="Ureidoglycolate lyase; pfam04115" /db_xref="CDD:427721" CDS 1..195 /gene="DAL3" /locus_tag="YIR032C" /coded_by="NM_001179554.1:1..588" /experiment="EXISTENCE:curator inference:GO:0000256 allantoin catabolic process [PMID:3915539]" /experiment="EXISTENCE:direct assay:GO:0050385 ureidoglycolate lyase activity [PMID:5965980]" /experiment="EXISTENCE:mutant phenotype:GO:0050385 ureidoglycolate lyase activity [PMID:3915539]" /note="Ureidoglycolate lyase; converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression is sensitive to nitrogen catabolite repression; this enzyme is sometimes referred to 'ureidoglycolate hydrolase' but should not be confused with the Arabidopsis thaliana ureidoglycolate hydrolase enzyme which converts ureidoglycolate to glyoxylate, ammonia and carbon dioxide" /db_xref="GeneID:854850" /db_xref="SGD:S000001471" ORIGIN 1 mvtvvaetlt kesfeeygti ispdeeisrm qnlekganqg taikllqvsq venkstskvp 61 nwnlfrcfpq phlnrvftqg snqaishsik vlekhpcstq tfvpmgrtsa evaylvvvak 121 eignkpdlst lraftclgnq avtyglgtwh apmivlgkee hldfsvliye sldpdrpekd 181 cveehysdgd vciii // LOCUS NP_012299 1113 aa linear PLN 30-JUN-2025 DEFINITION Mga2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012299 VERSION NP_012299.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179555.1 REFERENCE 1 (residues 1 to 1113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1113) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 1113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08580. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..1113 /product="Mga2p" /calculated_mol_wt="126924" Region 530..626 /region_name="IPT" /note="Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; cd00102" /db_xref="CDD:238050" Region <622..867 /region_name="PLN03192" /note="Voltage-dependent potassium channel; Provisional" /db_xref="CDD:215625" Region <712..820 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 719..750 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 752..782 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..1113 /gene="MGA2" /locus_tag="YIR033W" /coded_by="NM_001179555.1:1..3342" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19061897]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11007476]" /experiment="EXISTENCE:direct assay:GO:0106254 lipid sensor activity [PMID:27320200]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11063674]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9927444]" /experiment="EXISTENCE:genetic interaction:GO:2001280 positive regulation of unsaturated fatty acid biosynthetic process [PMID:9927444]" /experiment="EXISTENCE:mutant phenotype:GO:0010106 cellular response to iron ion starvation [PMID:29627385]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:29627385|PMID:11509659|PMID:11557770]" /experiment="EXISTENCE:mutant phenotype:GO:0048255 mRNA stabilization [PMID:15220333]" /experiment="EXISTENCE:mutant phenotype:GO:0071279 cellular response to cobalt ion [PMID:11509659]" /experiment="EXISTENCE:mutant phenotype:GO:0071456 cellular response to hypoxia [PMID:11509659]" /note="Lipid sensor of ER membrane that regulates OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; MGA2 has paralog SPT23 from the whole genome duplication" /db_xref="GeneID:854851" /db_xref="SGD:S000001472" ORIGIN 1 mqqnseflte tpgsdphisq lhansvmesq llddfllngs pmyqddsmah inideganfq 61 nfiktdegds pnllsfegig nnthvnqnvs tpleeemesn ralkeeeede henkvfnekn 121 ignpahdeiv fgrketiqsv yinpldylkv naaqlpldve vsglpqvsrv enqlklkvki 181 tsetplnqsm lylpsdsisr ekfylkknie dfsedfkknl lyinafvlca vsnrttnvct 241 kcvkreqrra arrksgiadn llwcnninrr lvvfnnkqvf pimktfdnvk efelttrlvc 301 ycrhhkanng fvilftitdw qnrllgkftt tpimitdrkp anmdttkfnn tttssrrqlt 361 eeestteyys tdnnqlskde nmpfqytyqh npydndsqmn niplkdknvp fpysisqqtd 421 llqnnnlsln lslpnqhips ptsmseegse sfnyhhrdnd npvrtisltn ieqqsqlnqr 481 krarnnlend igkplfkhsf snsisatntm npalhsmqdf smknnnnnlp sinrvipsqg 541 pinggievtl lgcnfkdgls vkfgsnlals tqcwsettiv tylppaayag qvfvsitdtn 601 nennnddlpq eieindnkka iftyvddtdr qlielalqiv glkmngkled arniakrivg 661 ndspdsgtng nscskstgps pnqhsmnlnt svlysdevli qkvikslnin snisicdslg 721 rtllhlaclk nysslvytli kkgarvndid sfgltplhfa cisgdpkiik mllnckvnys 781 lrshngltar evfianhihs keidkkqdnr dnhkfvhndt yisevlslfe efqngtkftd 841 svetdsnysi srkysqssfn sslldnesln enlfesqsmi nptsmeiqhp tlqlfenssy 901 seydqsdfee dgdedlfvtd evekpgvacr eeqselldig ssanepeedn gstslwnrvl 961 hrinddlpky edlfplswgk ddklkttnqd siveqsasni ensenseeed yeeeeeflkk 1021 qfnrffqnkq nfrndkmlif fwipltllll twfimykfgn qdssinhise liseylrial 1081 akfllgnerm ktafrsklsn lqttrmlndl ivs // LOCUS NP_012300 373 aa linear PLN 30-JUN-2025 DEFINITION saccharopine dehydrogenase (NAD+, L-lysine-forming) [Saccharomyces cerevisiae S288C]. ACCESSION NP_012300 VERSION NP_012300.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179556.3 REFERENCE 1 (residues 1 to 373) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 373) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 373) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 373) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08581. On Jul 30, 2012 this sequence version replaced NP_012300.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..373 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..373 /product="saccharopine dehydrogenase (NAD+, L-lysine-forming)" /EC_number="1.5.1.7" /calculated_mol_wt="41334" Region 4..365 /region_name="SDH" /note="Saccharopine Dehydrogenase NAD-binding and catalytic domains; cd12188" /db_xref="CDD:240664" Site order(18,77,94,96,122,131,135) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:240664" Site order(126..127,202,214,225,227,230,343,346,351) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:240664" Site order(130,136,139,199..200,202..205,227..228,231,250..251, 256,278..279,318..322) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:240664" CDS 1..373 /gene="LYS1" /locus_tag="YIR034C" /coded_by="NM_001179556.3:1..1122" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0004754 saccharopine dehydrogenase (NAD+, L-lysine-forming) activity [PMID:17002315]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0009085 lysine biosynthetic process [PMID:17247984]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:35563734]" /note="Saccharopine dehydrogenase (NAD+, L-lysine-forming); catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; contains mRNA binding activity; required for targeting of Pls1p to the peroxisomal matrix in the absence of lysine" /db_xref="GeneID:854852" /db_xref="SGD:S000001473" ORIGIN 1 maavtlhlra etkplearaa ltpttvkkli akgfkiyved spqstfnine yrqagaiivp 61 agswktaprd riiiglkemp etdtfplvhe hiqfahcykd qagwqnvlmr fikghgtlyd 121 leflendqgr rvaafgfyag fagaalgvrd wafkqthsdd edlpavspyp nekalvkdvt 181 kdykealatg arkptvliig algrcgsgai dllhkvgipd anilkwdike tsrggpfdei 241 pqadifinci ylskpiapft nmeklnnpnr rlrtvvdvsa dttnphnpip iytvatvfnk 301 ptvlvpttag pklsvisidh lpsllpreas effshdllps lellpqrkta pvwvrakklf 361 drhcarvkrs srl // LOCUS NP_012301 254 aa linear PLN 30-JUN-2025 DEFINITION sepiapterin reductase family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012301 VERSION NP_012301.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179557.3 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08582. On Jul 30, 2012 this sequence version replaced NP_012301.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..254 /product="sepiapterin reductase family protein" /calculated_mol_wt="27349" Region 4..246 /region_name="SPR-like_SDR_c" /note="sepiapterin reductase (SPR)-like, classical (c) SDRs; cd05367" /db_xref="CDD:187625" Site order(9..14,35..37,57..59,85..87,109,135..137,150,154, 178..181,183..186) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:187625" Site order(66,100..101,103..104,107..108,111..112,115..116,119, 139..141,148..149,151..152,156,159..160,163..164,166..168) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:187625" Site order(110,137,150,154) /site_type="active" /db_xref="CDD:187625" CDS 1..254 /gene="NRE1" /locus_tag="YIR035C" /coded_by="NM_001179557.3:1..765" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0102306 benzil reductase [(S)-benzoin-forming] activity [PMID:37602278]" /note="Benzil oxidoreductase with preference for NADPH; localizes to the cytoplasm; sequence similarity with short-chain dehydrogenase/reductases; putative paralog of IRC24" /db_xref="GeneID:854853" /db_xref="SGD:S000001474" ORIGIN 1 mgkvilvtgv srgigksivd vlfsldkdtv vygvarseap lkklkekygd rffyvvgdit 61 edsvlkqlvn aavkghgkid slvanagvle pvqnvneidv nawkklydin ffsivslvgi 121 alpelkktng nvvfvssdac nmyfsswgay gsskaalnhf amtlaneerq vkaiavapgi 181 vdtdmqvnir envgpssmsa eqlkmfrglk ennqlldssv patvyaklal hgipdgvngq 241 ylsyndpala dfmp // LOCUS NP_012302 263 aa linear PLN 30-JUN-2025 DEFINITION sepiapterin reductase family protein IRC24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012302 VERSION NP_012302.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179558.3 REFERENCE 1 (residues 1 to 263) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 263) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 263) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 263) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08583. On Jul 30, 2012 this sequence version replaced NP_012302.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..263 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..263 /product="sepiapterin reductase family protein IRC24" /EC_number="1.1.1.320" /calculated_mol_wt="28673" Region 4..255 /region_name="SPR-like_SDR_c" /note="sepiapterin reductase (SPR)-like, classical (c) SDRs; cd05367" /db_xref="CDD:187625" Site order(9..14,35..37,58..60,86..88,114,142..144,157,161, 187..190,192..195) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:187625" Site order(67,105..106,108..109,112..113,116..117,120..121,124, 146..148,155..156,158..159,163,166..167,170..171,173..175) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:187625" Site order(115,144,157,161) /site_type="active" /db_xref="CDD:187625" CDS 1..263 /gene="IRC24" /locus_tag="YIR036C" /coded_by="NM_001179558.3:1..792" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0050664 oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [PMID:11796169]" /experiment="EXISTENCE:direct assay:GO:0102306 benzil reductase [(S)-benzoin-forming] activity [PMID:37602278]" /note="Benzil oxidoreductase with preference for NADPH; localizes to the cytoplasm; induced by the DNA-damaging agent MMS; null mutant has elevated levels of spontaneous Rad52p foci; sequence similarity with short-chain dehydrogenase/reductases; putative paralog of IRC24" /db_xref="GeneID:854854" /db_xref="SGD:S000001475" ORIGIN 1 mgkvilitga srgiglqlvk tvieeddeci vygvarteag lqslqreyga dkfvyrvldi 61 tdrsrmealv eeirqkhgkl dgivanagml epvksisqsn sehdikqwer lfdvnffsiv 121 slvalclpll ksspfvgniv fvssgasvkp yngwsaygcs kaalnhfamd iaseepsdkv 181 ravciapgvv dtqmqkdire tlgpqgmtpk alerftqlyk tsslldpkvp aavlaqlvlk 241 gipdslngqy lrynderlgp vqg // LOCUS NP_012303 163 aa linear PLN 30-JUN-2025 DEFINITION peroxiredoxin HYR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012303 VERSION NP_012303.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179559.1 REFERENCE 1 (residues 1 to 163) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 163) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 163) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 163) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08584. Method: conceptual translation. FEATURES Location/Qualifiers source 1..163 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..163 /product="peroxiredoxin HYR1" /EC_number="1.11.1.24" /calculated_mol_wt="18510" Region 1..159 /region_name="BtuE" /note="Thioredoxin/glutathione peroxidase BtuE, reduces lipid peroxides [Defense mechanisms, Lipid transport and metabolism]; COG0386" /db_xref="CDD:440155" CDS 1..163 /gene="HYR1" /locus_tag="YIR037W" /gene_synonym="GPX3; ORP1" /coded_by="NM_001179559.1:1..492" /experiment="EXISTENCE:direct assay:GO:0004602 glutathione peroxidase activity [PMID:19755417]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:22659048]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity [PMID:11445588]" /experiment="EXISTENCE:mutant phenotype:GO:0004602 glutathione peroxidase activity [PMID:10480913]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11445588]" /experiment="EXISTENCE:mutant phenotype:GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity [PMID:11445588]" /note="Glutathione peroxidase; functions as hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce redox signal to Yap1p transcription factor; glutathione peroxidase activity is neuroprotective in models of Huntington's disease; HYR1 has a paralog, GPX1, that arose from the whole genome duplication" /db_xref="GeneID:854855" /db_xref="SGD:S000001476" ORIGIN 1 msefyklapv dkkgqpfpfd qlkgkvvliv nvaskcgftp qykelealyk rykdegftii 61 gfpcnqfghq epgsdeeiaq fcqlnygvtf pimkkidvng gnedpvykfl ksqksgmlgl 121 rgikwnfekf lvdkkgkvye ryssltkpss lsetieellk eve // LOCUS NP_012304 234 aa linear PLN 30-JUN-2025 DEFINITION bifunctional glutathione transferase/peroxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012304 VERSION NP_012304.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179560.1 REFERENCE 1 (residues 1 to 234) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 234) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 234) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 234) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08585. Method: conceptual translation. FEATURES Location/Qualifiers source 1..234 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..234 /product="bifunctional glutathione transferase/peroxidase" /EC_number="2.5.1.18" /calculated_mol_wt="26664" Region 6..87 /region_name="GST_N_GTT1_like" /note="GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; cd03046" /db_xref="CDD:239344" Site order(15,17..18,20..21,24..25,76,79..80) /site_type="other" /note="putative C-terminal domain interface [polypeptide binding]" /db_xref="CDD:239344" Site order(15,55..57,74..75) /site_type="other" /note="putative GSH binding site (G-site) [chemical binding]" /db_xref="CDD:239344" Site order(55,73..74,76..77,80) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:239344" Region 93..218 /region_name="GST_C_GTT1_like" /note="C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; cd03189" /db_xref="CDD:198298" Site order(104,111,181,184..185,188,192) /site_type="other" /note="putative N-terminal domain interface [polypeptide binding]" /db_xref="CDD:198298" Site order(104..105,108..109,112,162) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:198298" Site order(111,115..116,119..120,189,192) /site_type="other" /note="putative substrate binding pocket (H-site) [chemical binding]" /db_xref="CDD:198298" CDS 1..234 /gene="GTT1" /locus_tag="YIR038C" /coded_by="NM_001179560.1:1..705" /experiment="EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:9792709]" /experiment="EXISTENCE:direct assay:GO:0004602 glutathione peroxidase activity [PMID:16709151]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:9792709|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0006749 glutathione metabolic process [PMID:9792709]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0010731 protein glutathionylation [PMID:27708136]" /note="ER associated glutathione S-transferase; capable of homodimerization; glutathione transferase for Yvc1p vacuolar cation channel; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p" /db_xref="GeneID:854856" /db_xref="SGD:S000001477" ORIGIN 1 mslpiikvhw ldhsrafrll wlldhlnley eivpykrdan frappelkki hplgrsplle 61 vqdretgkkk ilaesgfifq yvlqhfdhsh vlmsedadia dqinyylfyv egslqpplmi 121 efilskvkds gmpfpisyla rkvadkisqa yssgevknqf dfvegeiskn ngylvdgkls 181 gadilmsfpl qmaferkfaa pedypaiskw lktitseesy aaskekaral gsnf // LOCUS NP_012305 537 aa linear PLN 30-JUN-2025 DEFINITION aspartyl protease [Saccharomyces cerevisiae S288C]. ACCESSION NP_012305 VERSION NP_012305.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179561.3 REFERENCE 1 (residues 1 to 537) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 537) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 537) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 537) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 537) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 537) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 537) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08586. On Jul 30, 2012 this sequence version replaced NP_012305.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..537 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..537 /product="aspartyl protease" /calculated_mol_wt="58083" Region 65..428 /region_name="SAP_like" /note="SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins; cd05474" /db_xref="CDD:133141" Site order(66,160,163,168,174,210,396,402) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:133141" Site order(85..88,324..327) /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:133141" Site order(85,324) /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:133141" Site order(161..166,168..172) /site_type="active" /note="Active site flap [active]" /db_xref="CDD:133141" CDS 1..537 /gene="YPS6" /locus_tag="YIR039C" /coded_by="NM_001179561.3:1..1614" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:16087741]" /note="Putative GPI-anchored aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance" /db_xref="GeneID:854857" /db_xref="SGD:S000001478" ORIGIN 1 mqlisilsll sslmcsltvl gssassyvkf pvqkladiin ictqdvstvf krnevlnttv 61 ingigvyvvk meigtppqtl ylqldtgssd mivnnadiay cksmsdgsdy astdnyelta 121 tfnglpstti sseayntlcs ywgtfdasns stfennatff nntygdgtyy agtygtdvvs 181 fenitlndft fgvsndtign psgilgislp iaeftdgiey alalnrtpfi ydnfpmelkn 241 qgkinkiays lflngpdahf gsilfgavdk skytgqlytl pmlqafntlg snpgmiitaq 301 svaildsesg nktvsdiqfp vmldsgttfs ylpteiaeai gksfdgeyss ddqgyifdcs 361 kvndtllsvd fggfnisani snfvtsakdr cvlnvkqses tymlgdaflv dayvvydlen 421 yeisiaqasf nnqeedievi sdtvpgatpa pgyfstwvyk pgspigtgdf invswtsyse 481 fsqyksllat aaqsddassf sssggssest tkkqnagyky rssfsfslls fisyfll // LOCUS NP_012307 124 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012307 VERSION NP_012307.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179563.1 REFERENCE 1 (residues 1 to 124) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 124) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 124) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 124) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08587. Method: conceptual translation. FEATURES Location/Qualifiers source 1..124 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..124 /product="seripauperin PAU15" /calculated_mol_wt="13028" Region 26..118 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..124 /gene="PAU15" /locus_tag="YIR041W" /coded_by="NM_001179563.1:1..375" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole" /db_xref="GeneID:854859" /db_xref="SGD:S000001480" ORIGIN 1 mvkltsiaag vaaiaagvaa apatttlsps dervnlvelg vyvsdirahl aqyylfqaah 61 psetypveia eavfnygdft tmltgipaeq vtrvitgvpw ystrlrpais salskdgiyt 121 aipk // LOCUS NP_012308 236 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YIR042C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012308 VERSION NP_012308.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179564.1 REFERENCE 1 (residues 1 to 236) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 236) AUTHORS Churcher,C., Bowman,S., Badcock,K., Bankier,A., Brown,D., Chillingworth,T., Connor,R., Devlin,K., Gentles,S., Hamlin,N., Harris,D., Horsnell,T., Hunt,S., Jagels,K., Jones,M., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Rowley,N., Skelton,J., Smith,V., Barrell,B. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome IX JOURNAL Nature 387 (6632 SUPPL), 84-87 (1997) PUBMED 9169870 REFERENCE 3 (residues 1 to 236) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 236) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08588. Method: conceptual translation. FEATURES Location/Qualifiers source 1..236 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="IX" Protein 1..236 /product="uncharacterized protein" /calculated_mol_wt="27291" Region 27..201 /region_name="RimL" /note="Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones]; COG1670" /db_xref="CDD:441276" CDS 1..236 /locus_tag="YIR042C" /coded_by="NM_001179564.1:1..711" /note="hypothetical protein; YIR042C is a non-essential gene" /db_xref="GeneID:854860" /db_xref="SGD:S000001481" ORIGIN 1 manlnifgqe vgadvegwtt rafpekvvlk gntcrlepld rerhgselfs ayseagqklw 61 tylpagpftn leeylefike lnetkdtvpf aiinketera vgtlclirid eangslevgy 121 vvfspelqkt iiateaqfll mkyvfddlqy rryewkcdsl ngpsrraamr lgfkyegtfr 181 qvvvykgrtr dtqwfsiidk ewlrirktfe ewldktnfen gkqkrgiaai reslsn // LOCUS NP_012311 1758 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012311 VERSION NP_012311.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181657.1 REFERENCE 1 (residues 1 to 1758) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1758) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1758) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1758) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08589. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1758 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1758 /product="Y' element ATP-dependent helicase" /EC_number="3.6.4.12" /calculated_mol_wt="197434" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 676..833 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Region 908..1003 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" Region 1556..>1609 /region_name="YccJ" /note="YccJ-like protein; cl23921" /db_xref="CDD:451607" CDS 1..1758 /locus_tag="YJL225C" /coded_by="NM_001181657.1:1..5277" /note="Putative Y' element ATP-dependent helicase" /db_xref="GeneID:853231" /db_xref="SGD:S000003760" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekvvisvmv gknvkkfltf vedepdfqgg pipskylipk kinlmvytlf 121 qvhtlkfnrk dydtlslfyl nrgyynelsf rvlercheia sarpndsstm rtftdfvsga 181 pivrslqkst irkygynlap ymflllhvde lsifsayqas lpgekkvdte rlkrdlcprk 241 pieikyfsqi cndmmnkkdr lgdilhiilr acalnfgagp rggagdeedr sitneepiip 301 svdehglkvc klrspntprr lrktldavka llvsscacta rdldifddnn gvamwkwiki 361 lyhevaqett lkdsyritlv pssdgislla fagpqrnvyv ddttrriqly tdynkngsse 421 prlktldglt sdyvfyfvtv lrqmqicalg nsydafnhdp wmdvvgfedp nqvtnrdisr 481 ivlysymfln takgclveya tfrqymrelp knapqklnfr emrqglialg rhcvgsrfet 541 dlyesatsel manhsvqtgr niygvdsfsl tsvsgttatl lqeraserwi qwlglesdyh 601 csfsstrnae dvvageaass nhhqkisrvt rkrprepkst ndilvagqkl fgssfefrdl 661 hqlrlcyeiy madtpsvavq appgygktel fhlplialas kgdveyvsfl fvpytvllan 721 cmirlgrrgc lnvapvrnfi eegydgvtdl yvgiyddlas tnftdriaaw enivectfrt 781 nnvklgyliv defhnfetev yrqsqfggit nldfdafeka iflsgtapea vadaalqrig 841 ltglakksmd inelkrsedl srglssyptr mfnlikekse vplghvhkir kkvesqpeea 901 lklllalfes epeskaivva sttneveela cswrkyfrvv wihgklgaae kvsrtkefvt 961 dgsmqvligt klvtegidik qlmmvimldn rlniieliqg vgrlrdgglc yllsrknswa 1021 arnrkgelpp ikegciteqv refygleskk gkkgqhvgcc gsrtdlsadt veliermdrl 1081 aekqatasms ivalpssfqe snssdryrky cssdedsntc ihgsanastn astnaittas 1141 tnvrtnattn astnattnas tnastnattn astnattnss tnatttastn vrtsatttas 1201 invrtsattt estnsstnat ttestnsstn atttestnsn tsatttasin vrtsatttes 1261 tnsstsattt asinvrtsat ttksinsstn atttestnsn tnatttestn sstnatttes 1321 tnsstnattt estnsntsaa ttestnsnts atttestnas akedankdgn aednrfhpvt 1381 dinkesykrk gsqmvllerk klkaqfpnts enmnvlqflg frsdeikhlf lygidiyfcp 1441 egvftqyglc kgcqkmfelc vcwagqkvsy rriawealav ermlrndeey keylediepy 1501 hgdpvgylky fsvkrreiys qiqrnyawyl aitrrretis vldstrgkqg sqvfrmsgrq 1561 ikelyfkvws nlresktevl qyflnwdekk cqeeweakdd tvvvealekg gvfqrlrsmt 1621 saglqgpqyv klqfsrhhrq lrsryelslg mhlrdqialg vtpskvphwt aflsmliglf 1681 ynktfrqkle ylleqisevw llphwldlan vevlaaddtr vplymlmvav hkeldsddvp 1741 dgrfdillcr dssrevge // LOCUS NP_012312 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012312 VERSION NP_012312.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181656.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 120) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08590. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..120 /product="seripauperin PAU1" /calculated_mol_wt="12735" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU1" /locus_tag="YJL223C" /coded_by="NM_001181656.1:1..363" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; active during alcoholic fermentation; regulated by anaerobiosis, negatively regulated by oxygen; repressed by heme; identical to Pau14p" /db_xref="GeneID:853232" /db_xref="SGD:S000003759" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ymfqaahpte 61 typvevaeav fnygdfttml tgispdqvtr mitgvpwyss rlkpaissal skdgiytian // LOCUS NP_012313 1549 aa linear PLN 30-JUN-2025 DEFINITION signal sequence-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012313 VERSION NP_012313.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181655.1 REFERENCE 1 (residues 1 to 1549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1549) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08591. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1549 /product="signal sequence-binding protein" /calculated_mol_wt="174272" Region 45..693 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" Region 728..1355 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" CDS 1..1549 /gene="VTH2" /locus_tag="YJL222W" /coded_by="NM_001181655.1:1..4650" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0005048 signal sequence binding [PMID:8636229]" /experiment="EXISTENCE:genetic interaction:GO:0006623 protein targeting to vacuole [PMID:8636229]" /experiment="EXISTENCE:genetic interaction:GO:0006896 Golgi to vacuole transport [PMID:8662642]" /note="Putative membrane glycoprotein; has strong similarity to Vth1p and Pep1p/Vps10p; may be involved in vacuolar protein sorting" /db_xref="GeneID:853233" /db_xref="SGD:S000003758" ORIGIN 1 malfralyii wvflliplsn aeeftpkvtr tlsryvfdiv nfddsntlir aeedsveisf 61 dagenwktid eieepiesfv vdpfrghdra fafvktapkf yvtddqgksw rpltipisek 121 asnyfcdvtt hpikkkhlii rcdlltikns glmyvgreiy ttndgvsfsq vkpsfgkidg 181 histarcdfi kssedsdlgg ndasilclfr nteyiestgs tidkselils adggetfkel 241 vqfkdkvvsr yeilkhhviv ltqddmynem sstniwisnd vstfqvartp tkirhvnmgq 301 ihedsigriv lpvsrerdde dsnqpgaaev lisdseglkf lpinwipnnq fgyinvaypg 361 flkgtffgsf hpfieysdrk rkysrqkvre etkvsvdngl twtnlkvvdr envdlfgcdv 421 tkpercslqt hfydlrnlnp sagimmisgi vgdgsaynwk eektfisrds gltwrlvhns 481 tglyttgdlg niimyipyrs nengdvpskf yysldqgktw geydlimpiy pyrlvstisd 541 gsgskfiltg tsitedpifi tysidfsavf dyksceegdf edwnladgkc vngakykyrr 601 rkqdaqclvk kafkdlslde tpcnsctgsd yecsfefvrd akgdcipdyn lialsdicdk 661 skgksvlvkp lqlikgdkck tpmkiesvdi pcdeipkegs sdkeivtten kfdfeikfyq 721 yfdtvadesl vmlnsigday ishdggqtik rfdtdgekiv eivfnpyfns saylfgskgn 781 iflthdrgys fmiaklpear qlgmpldfsa kaqdtfiyyg gkncesilsp echavayltk 841 dggetfteml dnaihcefag tlfkypsndd mvmcqvkekf sqtrslvsst dffqddrktv 901 feniigylst ggyiivavph ednelrayvt ndgaefteak fpydedigkq daftilgsee 961 gsiflhlatn lesghdfgnl lksnsngtsf vtlehavnrn tfgyvdfekv qglegiiitn 1021 ivsnsekvge nkedeqlktk itfndgsdwn flkppkkdse gkkfpcdsvs ldkcslhlhg 1081 yterkdirdt yssgsalgmm fgvgnvgdrl lpyeecstfl ttdggetwte vkkgphqwey 1141 gdhggvlvlv penaetdsis ystdfgktwk dykfcgdkvl vkdiitvprd salrfllfge 1201 aknmgsgsfr tytidfrnif erqcefditg rkradfkysp lgsrtgclfg hkteflrktd 1261 ekcfignipl sefsrnvknc pctrqdfecd ynfykasdgt cklvkglssa ngadickkep 1321 dlieyydssg yrkiplstck gglkldahla phpcpgkeka frekysintg ayalvfvtil 1381 lviffvawfv ydrgirrngg fsrfeeirlg ddgliennrt drvvniivrl glcislitks 1441 afqrakagta qlsskfrarf gnkkgatyss llhdqlsdep dgfhedsndl ssfrgqgsns 1501 eieqedvdts qqehtsrtdl lgasnipdal parsashesd laaarsedk // LOCUS NP_012314 589 aa linear PLN 30-JUN-2025 DEFINITION oligo-1,6-glucosidase IMA4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012314 VERSION NP_012314.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181654.1 REFERENCE 1 (residues 1 to 589) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 589) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 589) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 589) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08592. Method: conceptual translation. FEATURES Location/Qualifiers source 1..589 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..589 /product="oligo-1,6-glucosidase IMA4" /EC_number="3.2.1.10" /calculated_mol_wt="68568" Region 16..503 /region_name="AmyAc_SI_OligoGlu_DGase" /note="Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; cd11333" /db_xref="CDD:200472" Site order(30,32,34,38) /site_type="other" /note="Ca binding site [ion binding]" /db_xref="CDD:200472" Site order(69,72,109,112,159,178,182,215,277,442) /site_type="active" /db_xref="CDD:200472" Site order(215,277,352) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:200472" Region 514..585 /region_name="Malt_amylase_C" /note="Maltogenic Amylase, C-terminal domain; pfam16657" /db_xref="CDD:435493" CDS 1..589 /gene="IMA4" /locus_tag="YJL221C" /gene_synonym="FSP2" /coded_by="NM_001181654.1:1..1770" /experiment="EXISTENCE:genetic interaction:GO:0046352 disaccharide catabolic process [PMID:20562106]" /experiment="EXISTENCE:mutant phenotype:GO:0004574 oligo-1,6-glucosidase activity [PMID:20562106]" /note="Alpha-glucosidase; weak, but broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose; identical to IMA3" /db_xref="GeneID:853235" /db_xref="SGD:S000003757" ORIGIN 1 mtissahpet epkwwkeati yqiypasfkd snndgwgdmk giaskleyik elgtdaiwis 61 pfydspqddm gydianyekv wptygtnedc faliekthkl gmkfitdlvi nhcssehewf 121 kesrssktnp krdwffwrpp kgydaegkpi ppnnwrsyfg gsawtfdekt qefylrlfcs 181 tqpdlnwene dcrkaiyesa vgywldhgvd gfridvgsly skvaglpdap videnskwql 241 sdpftmngpr ihefhqemnk firnrvkdgr eimtvgemrh atdetkrlyt sasrhelsel 301 fnfshtdvgt spkfrqnlip yelkdwkval aelfryvngt dcwstiylen hdqprsitrf 361 gddspknrvi sgkllsvllv slsgtlyvyq gqelgeinfk nwpiekyedv evrnnydaik 421 eehgenskem krfleaiali srdhartpmq wsreepnagf sgpnakpwfy lnesfregin 481 aedeskdpns vlnfwkealr frkahkditv ygydfefidl dnkklfsftk kydnktlfaa 541 lnfssdsidf tipnnsssfk lefgnyprse vdassrtlkp wegriyise // LOCUS NP_012316 567 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012316 VERSION NP_012316.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181652.1 REFERENCE 1 (residues 1 to 567) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 567) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 567) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 567) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08593. Method: conceptual translation. FEATURES Location/Qualifiers source 1..567 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..567 /product="hexose transporter HXT9" /calculated_mol_wt="62727" Region 64..526 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(75,79,205,208..209,212,331..332,336..337,340..341, 366,438..439,442..443,447,470..471,474) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..567 /gene="HXT9" /locus_tag="YJL219W" /coded_by="NM_001181652.1:1..1704" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0005354 galactose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="Putative hexose transporter that is nearly identical to Hxt11p; has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p" /db_xref="GeneID:853236" /db_xref="SGD:S000003755" ORIGIN 1 msgvnntsan dlsttesnsn svanapsvkt ehndsknsln ldateppidl pqkplsaytt 61 vailclmiaf ggfifgwdtg tisgfvnlsd firrfgqknd kgtyylskvr mglivsifni 121 gcaiggivls kvgdiygrri glitvtaiyv vgiliqitsi nkwyqyfigr iisglgvggi 181 avlspmlise vapkqirgtl vqlyqlmctm giflgyctny gtknyhnatq wrvglglcfa 241 wttfmvsgmm fvpespryli evgkdeeakr slsksnkvsv ddpallaeyd tikagielek 301 lagnaswsel lstktkvfqr vlmgvmiqsl qqltgdnyff yygttifksv glkdsfqtsi 361 iigvvnffss fiavytierf grrtcllwga asmlccfavf asvgvtklwp qgsshqdits 421 qgagncmivf tmffifsfat twaggcyviv setfplrvks rgmaiataan wmwgflisff 481 tpfitgainf yygyvflgcl vfayfyvfff vpetkgltle evntmwlegv pawksaswvp 541 perrtadyda daidhddrpi ykrffss // LOCUS NP_012317 196 aa linear PLN 30-JUN-2025 DEFINITION acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012317 VERSION NP_012317.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181651.1 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 196) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08594. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..196 /product="acetyltransferase" /calculated_mol_wt="21348" Region 12..181 /region_name="LbH_MAT_GAT" /note="Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; cd03357" /db_xref="CDD:100047" Site order(15,25,70,82,84,90,92,102,104,110,112,114,116, 123..124,126,138,140..141,146,158..159,162,164..165, 174..177,179) /site_type="active" /db_xref="CDD:100047" Site order(15,25,70,82,84,90,92,102,112,114,123..124,126) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:100047" Site order(26,29,33,40,66,68..69,85..86,100,102,106,108,110,114, 116..118,120..121,127,129,136,138,141..143,146,154,156, 159..160,164,176) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:100047" Site order(110,112,114,116,138,140..141,146,158..159,164..165, 174..175,177) /site_type="other" /note="CoA binding site [chemical binding]" /db_xref="CDD:100047" CDS 1..196 /locus_tag="YJL218W" /coded_by="NM_001181651.1:1..591" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31945465]" /note="Mitochondrial protein, putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in OAF1/PIP2-dependent manner; promoter contains oleate response element consensus sequence; mutation decreases salt tolerance; non-essential gene" /db_xref="GeneID:853237" /db_xref="SGD:S000003754" ORIGIN 1 mgvlenivpg elydanydpd llkirketki klheyntlsp adenkksqvi rellgsctdn 61 fiieppfycd ygsniyigdn fyanhnlvil dgakvvigdn vfiapnvgiy taghpidver 121 rlqgleyamp vtigdnvwig ggvsiipgvn igknsviaag svvirdipen vvaagnpckv 181 irkitekdst ttnyrk // LOCUS NP_012318 198 aa linear PLN 30-JUN-2025 DEFINITION Ree1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012318 VERSION NP_012318.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181650.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 198) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08595. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..198 /product="Ree1p" /calculated_mol_wt="21836" Region 9..198 /region_name="Ree1" /note="Regulation of enolase protein 1 (function unknown), concanavalin A-like superfamily [Function unknown]; COG3506" /db_xref="CDD:442729" CDS 1..198 /gene="REE1" /locus_tag="YJL217W" /coded_by="NM_001181650.1:1..597" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle" /db_xref="GeneID:853238" /db_xref="SGD:S000003753" ORIGIN 1 mveskntels qgtwlnkpks vfqeagkvtl etdektdfwr etfygftrds ghflgvetgs 61 aftaqvrvqg syeslydqag imvriddghw lkagieisdg hamlssvltn gksdwstavy 121 ggnardfwlr vtvekgvlri qvssdkktwp lvrlapfpts dhylvgpmac tpergglkvt 181 fsewsltapl gkalhdls // LOCUS NP_012319 581 aa linear PLN 30-JUN-2025 DEFINITION oligo-1,6-glucosidase IMA5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012319 VERSION NP_012319.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181649.1 REFERENCE 1 (residues 1 to 581) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 581) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 581) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 581) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08596. Method: conceptual translation. FEATURES Location/Qualifiers source 1..581 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..581 /product="oligo-1,6-glucosidase IMA5" /EC_number="3.2.1.10" /calculated_mol_wt="67426" Region 11..498 /region_name="AmyAc_SI_OligoGlu_DGase" /note="Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; cd11333" /db_xref="CDD:200472" Site order(25,27,29,33) /site_type="other" /note="Ca binding site [ion binding]" /db_xref="CDD:200472" Site order(64,67,104,107,154,173,177,210,272,437) /site_type="active" /db_xref="CDD:200472" Site order(210,272,347) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:200472" Region 509..580 /region_name="Malt_amylase_C" /note="Maltogenic Amylase, C-terminal domain; cl02706" /db_xref="CDD:445893" CDS 1..581 /gene="IMA5" /locus_tag="YJL216C" /coded_by="NM_001181649.1:1..1746" /experiment="EXISTENCE:direct assay:GO:0004574 oligo-1,6-glucosidase activity [PMID:20471265]" /experiment="EXISTENCE:genetic interaction:GO:0046352 disaccharide catabolic process [PMID:20471265|PMID:20562106]" /experiment="EXISTENCE:mutant phenotype:GO:0004574 oligo-1,6-glucosidase activity [PMID:20562106]" /note="Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; most distant member of the IMA isomaltase family, but with similar catalytic properties as Ima1p and Ima2p; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose; can cleave alpha-1,3 linkage of nigerose and turanose and alpha-1,5 linkage of leucrose and is very sensitive to temperature in vitro" /db_xref="GeneID:853214" /db_xref="SGD:S000003752" ORIGIN 1 mtiihnpkww keatvyqiyp asfkdsnndg wgdlagitsk ldyvkelgvd aiwvcpfyds 61 pqedmgydia nyekvwpryg tnedcfqmie eahkrgikvi vdlvinhcse ehewfkesrs 121 skanpkrdwf fwrppkgyde kgnpippnnw rsffggsawr ydektgeffl hvfalgqpdf 181 nweneecrka iydssvgywl rhnvdgfrid vgsmyskveg lpdapitdpt vpyqkgteff 241 ingpriheyh kemhnymlsq vpegkeimtv gevgignedd frvytsakeg elnmmfnfkh 301 tsvgenpkck yelipftlkd fklalaesfl fientdcwst iylenhdqpr svsrfgsdsp 361 kwreisskml atliisltgt vfiyqgqelg mpnfknrkie qikcvegtgt yaaikrdyge 421 dsekmkkffe alalisrdhg rtpfpwsade psagfskdak pwidmnesfr dginaeaelk 481 dknsvfffwk kalqvrkehk dilvyghnfq fidldndklf mftkdtdnkk mfavfnfssd 541 ntdfsvpdne asytmffgny ansngdsrtl qpwegrlyll k // LOCUS NP_012321 569 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012321 VERSION NP_012321.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181647.1 REFERENCE 1 (residues 1 to 569) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 569) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 569) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 569) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08597. Method: conceptual translation. FEATURES Location/Qualifiers source 1..569 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..569 /product="hexose transporter HXT8" /calculated_mol_wt="63362" Region 69..530 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(80,84,211,214..215,218,337..338,342..343,346..347, 372,442..443,446..447,451,474..475,478) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..569 /gene="HXT8" /locus_tag="YJL214W" /coded_by="NM_001181647.1:1..1710" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="hypothetical protein with similarity to hexose transporters; expression is induced by low levels of glucose and repressed by high levels of glucose" /db_xref="GeneID:853216" /db_xref="SGD:S000003750" ORIGIN 1 mtdrktnlpe epifeeaedd gcpsienssh lsvptveenk dfseyngeea eevvvpekpa 61 sayatvsimc lcmafggfms gwdtgtisgf vnqtdflrrf gnyshsknty ylsnvrtgli 121 vsifnvgsai gclflsklgd iygrcmglii vivvymvgiv iqiasidkwy qyfigriiag 181 igagsisvla pmlisetapk hirgtllacw qlmvtfaifl gyctnygtkt ysnsvqwrvp 241 lglcfawaii miggmtfvpe sprflvqvgk ieqakasfak snklsvddpa vvaeidllva 301 gveaeeamgt aswkelfsrk tkvfqrltmt vminslqqlt gdnyffyygt tifksvgmnd 361 sfetsivlgi vnfascffsl ysvdklgrrr clllgaatmt acmviyasvg vtrlypngks 421 epsskgagnc tivftcfyif cfsctwgpvc yviisetfpl rvrskcmsva taanllwgfl 481 igfftpfits ainfyygyvf mgclafsyfy vfffvpetkg ltleevdemw mdgvlpwkse 541 swvpasrrdg dydneklqhd ekpfykrmf // LOCUS NP_012322 331 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL213W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012322 VERSION NP_012322.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181646.1 REFERENCE 1 (residues 1 to 331) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 331) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 331) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 331) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08598. Method: conceptual translation. FEATURES Location/Qualifiers source 1..331 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..331 /product="uncharacterized protein" /calculated_mol_wt="35774" Region 3..314 /region_name="Met_dep_hydrolase_A" /note="Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; cd01299" /db_xref="CDD:238624" CDS 1..331 /locus_tag="YJL213W" /coded_by="NM_001181646.1:1..996" /note="hypothetical protein that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p" /db_xref="GeneID:853217" /db_xref="SGD:S000003749" ORIGIN 1 mlmpksvall rirytleaal argfttvrdc ggaegflkae irqgslngpr litcghaisq 61 tgghgdlrsg alpasafdsc schfgqvgvv adgvpecyka areefrrgad fikimggggv 121 asptdkisnk qfcddeikal vdvansyhty vtahaytaea iqnciklgvk giehgnllde 181 rtaelmaelg cyltptlvty kvmgsdqfsa flgpensrkn tevlykgida mkiaqkkkvk 241 icfgsdllgp lygyqtqefr irgkvqttqe illsatvtpa emnglgdklg qikpgfiadl 301 lmmksnpldd itildepesn ilfvmkegri y // LOCUS NP_012323 799 aa linear PLN 30-JUN-2025 DEFINITION oligopeptide transporter OPT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012323 VERSION NP_012323.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181645.1 REFERENCE 1 (residues 1 to 799) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 799) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 799) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 799) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08599. Method: conceptual translation. FEATURES Location/Qualifiers source 1..799 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..799 /product="oligopeptide transporter OPT1" /calculated_mol_wt="91485" Region 88..760 /region_name="OPT_sfam" /note="oligopeptide transporter, OPT superfamily; TIGR00728" /db_xref="CDD:273236" CDS 1..799 /gene="OPT1" /locus_tag="YJL212C" /gene_synonym="DUG4; GSH11; HGT1" /coded_by="NM_001181645.1:1..2400" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19496824]" /experiment="EXISTENCE:direct assay:GO:0006857 oligopeptide transport [PMID:16149917]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:10788431]" /experiment="EXISTENCE:mutant phenotype:GO:0035673 oligopeptide transmembrane transporter activity [PMID:10652283]" /note="Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family" /db_xref="GeneID:853218" /db_xref="SGD:S000003748" ORIGIN 1 mstiyresds lesepsptpt tipiqinmee ekkdafvkni dedvnnltat tdeedrdpes 61 qkfdrhsiqe eglvwkgdpt ylpnspypev rsavsieddp tirlnhwrtw flttvfvvvf 121 agvnqffslr ypsleinflv aqvvcypigr ilallpdwkc skvpffdlnp gpftkkehav 181 vtiavaltss tayamyilna qgsfynmkln vgyqfllvwt sqmigygaag ltrrwvvnpa 241 ssiwpqtlis vslfdslhsr kvektvangw tmpryrffli vligsfiwyw vpgflftgls 301 yfnvilwgsk trhnfianti fgtqsglgal pitfdytqvs qamsgsvfat pfyvsantya 361 svliffvivl pclyftntwy akympvisgs tydntqnkyn vtkilnedys inlekykeys 421 pvfvpfsyll syalnfaavi avfvhcilyh gkdivakfkd rknggtdihm riysknykdc 481 pdwwylllqi vmiglgfvav ccfdtkfpaw afviailisl vnfipqgile amtnqhvgln 541 iitelicgym lplrpmanll fklygfivmr qglnlsrdlk lamymkvspr lifavqiyat 601 iisgmvnvgv qewmmhnidg lcttdqpngf tcangrtvfn asiiwslpky lfssgriynp 661 lmwffligll fplavyavqw kfpkfkfakh ihtpvfftgp gnippstpyn yslffamsfc 721 lnlirkrwra wfnkynfvmg agveagvais vviiflcvqy pggklswwgn nvwkrtydnd 781 ykkfytlkkg etfgydkww // LOCUS NP_012325 271 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein ligase peroxin 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012325 VERSION NP_012325.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181643.1 REFERENCE 1 (residues 1 to 271) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 271) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 271) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 271) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08600. Method: conceptual translation. FEATURES Location/Qualifiers source 1..271 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..271 /product="ubiquitin-protein ligase peroxin 2" /EC_number="2.3.2.36" /calculated_mol_wt="30621" Region 13..212 /region_name="Pex2_Pex12" /note="Pex2 / Pex12 amino terminal region; pfam04757" /db_xref="CDD:398431" CDS 1..271 /gene="PEX2" /locus_tag="YJL210W" /gene_synonym="CRT1; PAS5" /coded_by="NM_001181643.1:1..816" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:35768507|PMID:12876220]" /experiment="EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0016558 protein import into peroxisome matrix [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0016560 protein import into peroxisome matrix, docking [PMID:9094717]" /experiment="EXISTENCE:direct assay:GO:0016561 protein import into peroxisome matrix, translocation [PMID:20154681]" /experiment="EXISTENCE:direct assay:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:35768507|PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:0043335 protein unfolding [PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:0044721 protein import into peroxisome matrix, substrate release [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:35768507|PMID:19687296|PMID:22471590]" /experiment="EXISTENCE:direct assay:GO:1902495 transmembrane transporter complex [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:35768507|PMID:22375831]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:15536088]" /note="RING-finger peroxin and E3 ubiquitin ligase; peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import" /db_xref="GeneID:853219" /db_xref="SGD:S000003746" ORIGIN 1 msrvaqldsi aldkelygqf wsefnaafnt sehkeewela lntvvfmcat rflphygssc 61 tygsalsgvv fqcrkrtlyv vtvlagyvwk kithiifngp hcgnqmmwlk lykwvnllyh 121 gcdvtnflrf laaegpnara flsplyrafn vhstrlirdg saiasefysn svfagleyqn 181 rqllwnalle lfsntlltkr glltfvkkpp rsrstttykt vcprcggfpt npyqiaccra 241 nycyvcvvka lewsmcdacg ssgrltaspv y // LOCUS NP_012326 654 aa linear PLN 30-JUN-2025 DEFINITION Cbp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012326 VERSION NP_012326.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181642.1 REFERENCE 1 (residues 1 to 654) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 654) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 654) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 654) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08601. Method: conceptual translation. FEATURES Location/Qualifiers source 1..654 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..654 /product="Cbp1p" /calculated_mol_wt="76041" CDS 1..654 /gene="CBP1" /locus_tag="YJL209W" /coded_by="NM_001181642.1:1..1965" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:9343381]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:2104848|PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0000958 mitochondrial mRNA catabolic process [PMID:9343381]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:9343381]" /note="Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress" /db_xref="GeneID:853221" /db_xref="SGD:S000003745" ORIGIN 1 mflprlvryr terfikmvpt rtlrrinhss rdpiqkqvla likananlnd ndklkirkyw 61 sdmadykslr kqenslless ilhevkiedf isfinrtkts smttrgiyrr eclyqckknl 121 dlvnqvvsqv ssvrhqkplt tqldtmrwcv ddaigtgdiv maadlfllyy rlftddkkld 181 eqyakkiisv laypnplhdh vhlvkylqln slfesitggg ikltrfqlet lsnkalglsn 241 eapqlckail nklmninysl tndlklrddq vllaykside nyrrgnvasv ysiwnkikeh 301 yvsisahdsr iiykvfkict hnrayrsics emfwqltpey ycnnplilpa iidfitkqds 361 ltmakelmqn inrytlpenh hivwlnkrcl ssllrmhlkf ndsngvdrvl kqittnfral 421 sqenyqaiii hlfktqnldh iakavklldt ippgqamlay gsiinevvdw klaskvkftd 481 nlmalvndll tkahdfdpdh rnslwnvvsa lyikklchyk krdgkfvana kkdidlakll 541 yinaakrskt ywtksncnpf iasspcdvkl kvnnqnrfti lrnialsalq igrtdiflwa 601 caelyqngmt ieelkldwnf ilkhqirnse fktnkeiiqd ikkhgvsavk rylr // LOCUS NP_012327 329 aa linear PLN 30-JUN-2025 DEFINITION ribonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_012327 VERSION NP_012327.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181641.1 REFERENCE 1 (residues 1 to 329) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 329) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 329) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 329) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08602. Method: conceptual translation. FEATURES Location/Qualifiers source 1..329 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..329 /product="ribonuclease" /calculated_mol_wt="37078" Region 74..290 /region_name="NUC" /note="DNA/RNA non-specific endonuclease; smart00477" /db_xref="CDD:214683" Site order(135..136,138,170,178,182) /site_type="active" /db_xref="CDD:238043" Site order(135..136,182) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238043" Site 170 /site_type="other" /note="Mg2+ binding site [ion binding]" /db_xref="CDD:238043" CDS 1..329 /gene="NUC1" /locus_tag="YJL208C" /coded_by="NM_001181641.1:1..990" /experiment="EXISTENCE:direct assay:GO:0004520 DNA endonuclease activity [PMID:3286639]" /experiment="EXISTENCE:direct assay:GO:0004529 DNA exonuclease activity [PMID:3286639]" /experiment="EXISTENCE:direct assay:GO:0004540 RNA nuclease activity [PMID:3286639]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17244531]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:3286639|PMID:17244531]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:31266891]" /experiment="EXISTENCE:direct assay:GO:0006308 DNA catabolic process [PMID:3286639]" /experiment="EXISTENCE:direct assay:GO:0006401 RNA catabolic process [PMID:3286639]" /experiment="EXISTENCE:direct assay:GO:0051607 defense response to virus [PMID:31266891]" /experiment="EXISTENCE:mutant phenotype:GO:0006309 apoptotic DNA fragmentation [PMID:22727375]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:8087883]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17244531]" /note="Major mitochondrial nuclease; has RNAse and DNA endo- and exonucleolytic activities; prevents genome instability by degrading extranuclear DNA sequences; roles in mitochondrial recombination, apoptosis and maintenance of polyploidy; involved in fragmentation of genomic DNA during PND (programmed nuclear destruction); role in preventing L-A mycovirus pathogenesis; encodes ortholog of mammalian endoG" /db_xref="GeneID:853222" /db_xref="SGD:S000003744" ORIGIN 1 mcsrillsgl vglgagtglt ylllnkhspt qiietpyppt qkpnsniqsh sfnvdpsgff 61 kygfpgpihd lqnreefisc ynrqtqnpyw vlehitpesl aarnadrkns ffkedevipe 121 kfrgklrdyf rsgydrghqa paadakfsqq amddtfylsn mcpqvgegfn rdywahleyf 181 crgltkkyks vrivtgplyl pkkdpidnkf rvnyevignp psiavpthff klivaeapta 241 nparediava afvlpnepis netkltdfev pidalerstg lellqkvpps kkkalckevn 301 cqivvrdfsn aaikqskdvk llpppkkrn // LOCUS NP_012328 2014 aa linear PLN 30-JUN-2025 DEFINITION AP-1 complex accessory protein LAA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012328 VERSION NP_012328.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181640.1 REFERENCE 1 (residues 1 to 2014) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2014) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2014) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 2014) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08603. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2014 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..2014 /product="AP-1 complex accessory protein LAA1" /calculated_mol_wt="229770" Region 1353..1533 /region_name="Laa1_Sip1_HTR5" /note="Laa1/Sip1/HEATR5 HEAT repeat region; pfam20210" /db_xref="CDD:466361" CDS 1..2014 /gene="LAA1" /locus_tag="YJL207C" /coded_by="NM_001181640.1:1..6045" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:16687571]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:16687571]" /experiment="EXISTENCE:mutant phenotype:GO:0035653 clathrin-coated vesicle cargo loading, AP-1-mediated [PMID:30523155]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:16687571]" /note="AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene" /db_xref="GeneID:853223" /db_xref="SGD:S000003743" ORIGIN 1 manrslkkvi etssnnghdl ltwittnlek liclkevndn eiqevkeiht qldefvryis 61 vlentddlel hsvfislsql ytisiwrlkd eypgvvfdsa afltnvlcee dvsiddgdtd 121 pnqkkkkkks stkkkkyiys pakdiactil vqlfenfgss isslipllfn aifknlkkim 181 ekskyyhatf mttllqlfna ilrnsnnddk ildpatyakf sklsktvfds istdekdfsv 241 tfvsvliecw tahfkqtnfi rehshdiiet iysrftegei gvygfandet riftakslae 301 ilfdyyfskn iltlqevwsi yvkiflncdt rdvesgcfes iihlinlnll adntflsnsk 361 yldivlslsg vfssyevnnr smntlsrylr yfqhmhevil phlndsaktq mlyyilgcsd 421 tyqsssksds asnfkysida kpetqwltll qldftyvlis dlgstfttee ntvkeirdkl 481 vdlatceift irvhtveilk vflnncpeyl setienslra lstdfkstgk fifhknhgha 541 fiianlikga esdyisyeli mritvfstsf iknnttstss nlyfkgllcw illiglmnyk 601 deqylklqip qlflfwkvll thtytyhded elyknleirn haltclltyl snttidkema 661 kqvsylltkc snfnhsidlk sknidnallh nenrilqvyl klekyinsdf nssllilivk 721 nfsdpnlyte ssssvlgslk dignrkvsnk ddmesnivle ssintllrqn ngfafglssk 781 itgdrivnls mssaykydes isgswpskdy nwynifevev skpispilsl dslillygsg 841 sysqidryap qvttslidss melfssvfpf lnskiqysim etlnlsmfsk mttplrsvav 901 aanvcsalhn alrimqennl eldysvgqli iesikkiqff ndifltkika dcvglltaai 961 artlgdeerq kflteqsrif iknvadmdep ylrmfhvlsl atifkynsqy anfeeyfdvi 1021 falmrdphpv vhswslkamh illekhlvid lktaalllss meellvqdky giygrstlrc 1081 nynrdfnshv aigeisrtlt etvgpnflel ntkvldsfrn itlsmlisnn ilnsitsikm 1141 feniatfkmk nilnyeifil asksiikssi vtgigssyfd ttftgsneli srtsslkgaf 1201 enfdlltlly klqmeeffmk emenlswryl alfpnsgsvk nyftewilht fkrdnhwfdk 1261 lysifnmslg rlfqsynrdv sallevnglk kssekeikge eeesianvnq ltdtdaggld 1321 senlqwksrq iilnlilmlc lesekyenll lalsnkiadl ikisfrgstv rnegmkltgl 1381 hilnfvlkny stmrdpqvpg ssileqqeaq itsalmpafs kgssptvmsf aitvaaevla 1441 snimppdklg risqllidll gnfkdpnsgi rigeaiivtp kakrkielav ldawaevvqr 1501 sitssndalf sftrkywsil vplwiislre ymmikyndnd stvqvkndsk enslieprst 1561 kielyepvwl nfvealgctl dsdvqvilas lndeeleyfl filfsqclea ivkniddhsv 1621 kmqvlpalhn vlksnlciks ifeddiitev veimdrlist gdskeefllv diisdliigy 1681 skcnatpetf lqdidklyel lrllmtiise rlpfikynvl tseeddneik isptdisllk 1741 ktfiafesni snfdnmfkvd lyscllfiig kiyecshrev iipiilplfk alvkaltese 1801 deknivllei fygsikdviy hkldsknkva tilillsngy sklsfqelnq canilsealn 1861 npatqpialq gfkriisnif kypllqyfmk lvikrffqdi qtndslsqas iktkliiqfs 1921 eevikqdhqk aslsialcls ffaayhsayt ekidnevasg ivalakldkn sfkeaissti 1981 spqqkaiigs vmeayvksqs lgsveeafql ksfd // LOCUS NP_012329 758 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL206C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012329 VERSION NP_012329.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181638.1 REFERENCE 1 (residues 1 to 758) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 758) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 758) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 758) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08604. Method: conceptual translation. FEATURES Location/Qualifiers source 1..758 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..758 /product="uncharacterized protein" /calculated_mol_wt="86532" Site order(42,46,51..54,56,59,68) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Region 45..82 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(47,50,57,63,66,73) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 181..614 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..758 /locus_tag="YJL206C" /coded_by="NM_001181638.1:1..2277" /note="hypothetical protein; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment" /db_xref="GeneID:853224" /db_xref="SGD:S000003741" ORIGIN 1 mtpkesgkpi scamkklkgk rskilvlsrd agtnelkptk grahraciac rkrkvrcsgn 61 ipcrlcqtns yeckydrppr nssvfdrevs ddsslyaqra sheredskgp issidykkvv 121 etifppetlr qilasssfns qnfldtiktc llqgqlnvnq virqslpkdt pwhmqtsvpl 181 ppreialkfi qktwdcacvl frfyhrptii sildsiyeae khgkqytpeq vktqpliysv 241 lavgalfske dlskdskatr efytdegyry fleaknsldf snitdiysiq aifmmtiflq 301 csanlkacys figialraal keglhrrssi vgptpiqdet kkrlfwsvyk ldlymncilg 361 fpsgidesdi dqefpldvdd enistigikf qdwrtisscg mnnkhtklil imsriyklmy 421 slrrkpleed srtqivslnd qldnwyaqlp dilkvdtiry rqtqppltvs andtsspytk 481 pkkllyldfl lskivlykpf yhyisidpld ipefqfqihm aencievakk viqlsyemit 541 qnllsgsywf sihtiffsva clkfyvyqte kglirngkvd sdihnatqlg seilsllkga 601 snaskrtfev lnqlfkefne ktsvlseqll nivklqrqes sgalvpqlqt nnnftkcqge 661 lhhgqqhhqt patslrsiln lpqgeadlkf qntnneshtt taaqeeyldk llaefeefdy 721 sinrvlpdvi dfsaligqds sannqifsse fssdptvn // LOCUS NP_012330 53 aa linear PLN 30-JUN-2025 DEFINITION Nce101p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012330 VERSION NP_012330.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181639.1 REFERENCE 1 (residues 1 to 53) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 53) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 53) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 53) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08605. Method: conceptual translation. FEATURES Location/Qualifiers source 1..53 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..53 /product="Nce101p" /calculated_mol_wt="6205" Region 7..50 /region_name="NCE101" /note="Non-classical export protein 1; pfam11654" /db_xref="CDD:402998" CDS 1..53 /gene="NCE101" /locus_tag="YJL205C" /gene_synonym="NCE1; YJL205C-A; YJL206C-A" /coded_by="NM_001181639.1:1..162" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0009306 protein secretion [PMID:8655575]" /note="hypothetical protein; involved in secretion of proteins that lack classical secretory signal sequences; SWAT-GFP and mCherry fusion proteins localize to the cytosol" /db_xref="GeneID:853225" /db_xref="SGD:S000003742" ORIGIN 1 mvqyapfllg kfsdpllaim vgclsyyvye rkmgrpqghh lhelikkrwd drk // LOCUS NP_012331 840 aa linear PLN 30-JUN-2025 DEFINITION Rcy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012331 VERSION NP_012331.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181637.1 REFERENCE 1 (residues 1 to 840) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 840) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 840) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 840) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08606. Method: conceptual translation. FEATURES Location/Qualifiers source 1..840 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..840 /product="Rcy1p" /calculated_mol_wt="97341" Region 8..38 /region_name="F-box_SF" /note="F-box domain superfamily; cd09917" /db_xref="CDD:438852" Site order(9..11,14..15,18,29..31,33,36) /site_type="other" /note="F-box motif" /db_xref="CDD:438852" Site order(10,13..14,17..18,22,24..25,29..31,33) /site_type="other" /note="Skp1 binding site [polypeptide binding]" /db_xref="CDD:438852" Region 101..827 /region_name="Sec10" /note="Exocyst complex component Sec10; pfam07393" /db_xref="CDD:399988" CDS 1..840 /gene="RCY1" /locus_tag="YJL204C" /coded_by="NM_001181637.1:1..2523" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:15537705]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15537705]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:11287615]" /experiment="EXISTENCE:mutant phenotype:GO:0000149 SNARE binding [PMID:11287615]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903|PMID:10769031]" /experiment="EXISTENCE:mutant phenotype:GO:0032456 endocytic recycling [PMID:24272750]" /experiment="EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:15537705]" /note="F-box protein involved in recycling endocytosed proteins; involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth; direct interaction with C-terminal cytoplasmic region of Drs2p plays an important role for Drs2p function in endocytic recycling pathway; required for turnover of histone H3 variant Cse4p" /db_xref="GeneID:853226" /db_xref="SGD:S000003740" ORIGIN 1 mddllkvpei vtniasylst vdylsfqqvn krvyaiingk ndskywslkl trmglqqvhs 61 neeeeitlld endnqnslri feiyksftaq nskkifvkfy rcynsyarkl ynnnlanffp 121 tsysndplkq trilnfikky nfsnkndiet ftrietnfni lreifinsvl keselnyqsn 181 nlaavarfmk illisneesn aieffkskad lppsltvlps ndelfwaeqp reedsggstv 241 ifnsknldtf lnqlrdflne kikladilfk defpvilqfi esfiqdilld ilnnillsys 301 eflkengkds kanyecvpel yftfikkfdt elndsvnaga nfrkvvrdll nlylepfvvn 361 ymnqttrvfe slinsqlany dtqvqdkqre qnakiyntlk dqtdassasn nelpndlsii 421 tetsktvpea dskpstihqs vhstdisndk ldflssftki fkfsnnenqr lkqqlqlayn 481 lnlisnnlqn ikslisldlc ykilqetsek tdqiykfhti esllpliklr cqeifkilit 541 qlnknhvkpa fekailllqk ynpneieqie ikfnslspan tqveplvqft elinigdiil 601 qmisifykne lipkkiidkn kdflndviql kknfetsidd fvaeglnigi nklmdeisfv 661 fktlqlpddy nppppsrnsp irdikptkca irvvellsnh cflltgatdk gtidvyqqei 721 gerffneivk hlkkcfiste gaiwlicdln yfydfiankl kqknvvpyfv glksigqlyi 781 isgkdskelg klisdlgkfn giftqeeiye fvqrrsdwvr vrkdvekvmy glgirdccim // LOCUS NP_012332 280 aa linear PLN 30-JUN-2025 DEFINITION Prp21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012332 VERSION NP_012332.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181636.1 REFERENCE 1 (residues 1 to 280) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 280) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 280) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 280) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08607. Method: conceptual translation. FEATURES Location/Qualifiers source 1..280 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..280 /product="Prp21p" /calculated_mol_wt="32921" Region 9..55 /region_name="SWAP" /note="Suppressor-of-White-APricot splicing regulator; smart00648" /db_xref="CDD:197818" Region 93..144 /region_name="SWAP" /note="Suppressor-of-White-APricot splicing regulator; smart00648" /db_xref="CDD:197818" CDS 1..280 /gene="PRP21" /locus_tag="YJL203W" /gene_synonym="SPP91" /coded_by="NM_001181636.1:1..843" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:8969185]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8065365]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /note="Subunit of the SF3a splicing factor complex; required for spliceosome assembly" /db_xref="GeneID:853227" /db_xref="SGD:S000003739" ORIGIN 1 mepedtqlke dikttvnyik qhgvefenkl lederfsfik kddplheyyt klmneptdtv 61 sgedndrkse reiarppdfl fsqydtgisr rdmeviklta ryyakdksiv eqmiskdgea 121 rlnfmnsshp lhktftdfva qykrvysftg qeikkskrti ldncfertqy wefekdkdre 181 hdklvelcki qfaaipwdkf tqvakfsipe dteifegsld leqmrlrrvq tgiklfdsik 241 ptneeekivs dqgkqkggds kgkkrkirav getrlkkskk // LOCUS NP_012334 599 aa linear PLN 30-JUN-2025 DEFINITION Ecm25p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012334 VERSION NP_012334.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181634.1 REFERENCE 1 (residues 1 to 599) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 599) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 599) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 599) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08608. Method: conceptual translation. FEATURES Location/Qualifiers source 1..599 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..599 /product="Ecm25p" /calculated_mol_wt="68333" Region 21..167 /region_name="CRAL_TRIO_2" /note="Divergent CRAL/TRIO domain; pfam13716" /db_xref="CDD:463965" Region 190..359 /region_name="RhoGAP" /note="GTPase-activator protein for Rho-like GTPases; smart00324" /db_xref="CDD:214618" Site order(215,251,256,319,322..323,345) /site_type="other" /note="GTPase interaction site" /db_xref="CDD:238090" Site 215 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:238090" Region <376..>519 /region_name="Herpes_BLLF1" /note="Herpes virus major outer envelope glycoprotein (BLLF1); pfam05109" /db_xref="CDD:282904" CDS 1..599 /gene="ECM25" /locus_tag="YJL201W" /coded_by="NM_001181634.1:1..1800" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0042805 actinin binding [PMID:34010635]" /experiment="EXISTENCE:mutant phenotype:GO:0051510 regulation of unidimensional cell growth [PMID:34010635]" /experiment="EXISTENCE:mutant phenotype:GO:0080135 regulation of cellular response to stress [PMID:34010635]" /note="Endocytic site protein required for stress-induced cell elongation; may link the polarization signal with the endocytic machinery to facilitate adaptive morphogenesis under conditions of stress; interacts with the polarity regulator Cdc42p, the SH3 domains of actin patch components and actin filaments; contains a Rho-GAP domain lacking the catalytic arginine finger, PXXP motifs and an xACT (F-actin binding) motif; promoter contains a consensus binding sequence for transcription factor Abf1p" /db_xref="GeneID:853229" /db_xref="SGD:S000003737" ORIGIN 1 midinvnnif frsysvdpns ghaiyvfdst ylpasdeigd kqvydllina lmdrlvmklp 61 qapyslvifs sgfsqrkisw vygikmfakl pketkfylqk ifivhesffv rsvyqvisna 121 mnfnfldskd sqhdfpslvh vldltslsel iditrlrisl nvylydyqir ehinvpeeyy 181 nrltplairq yrqlvfdkif kklqndallc elifqkpgny kkvnifldii krnnyidlsq 241 wdiyslasvw lnyfiknkak plipielipl pivddlkfts etfrkiikfn qyqdlfmvii 301 pffnriiahg estkhdsrtl skaltpalck eklsmmtndr laigsryikn lldffpeiak 361 eissppssvs ssstipvlpk prkssptrys elgcltlprs rspspqrsvt sptytpvalq 421 ntpvlkpkss srnvsspsfn akpplpikav trpqlsltsn sntdlalass stdtlssptk 481 tpsadslpls nsstdltisd nikemvkdep akdknsvetd ifvqqfeslt lvqnakikkf 541 dkelqekkkk nettsktadk fsqkgysdik asnkvsrlaa lyeerlqglq vmnemkqrw // LOCUS NP_012335 789 aa linear PLN 30-JUN-2025 DEFINITION aconitate hydratase ACO2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012335 VERSION NP_012335.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181633.1 REFERENCE 1 (residues 1 to 789) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 789) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 789) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 789) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 789) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 789) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 789) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08609. Method: conceptual translation. FEATURES Location/Qualifiers source 1..789 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..789 /product="aconitate hydratase ACO2" /calculated_mol_wt="86452" Region 35..782 /region_name="aconitase_mito" /note="aconitate hydratase, mitochondrial; TIGR01340" /db_xref="CDD:273561" CDS 1..789 /gene="ACO2" /locus_tag="YJL200C" /coded_by="NM_001181633.1:1..2370" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0006099 tricarboxylic acid cycle [PMID:30834327]" /note="Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol" /db_xref="GeneID:853230" /db_xref="SGD:S000003736" ORIGIN 1 mlssanrfyi krhlathanm fpsvsknfqt kvppyakllt nldkikqitn napltlaeki 61 lyshlcdpee sitssdlsti rgnkylklnp drvamqdasa qmallqfmtt glnqtsvpas 121 ihcdhlivgk dgetkdlpss iatnqevfdf lescakrygi qfwgpgsgii hqivlenfsa 181 pglmmlgtds htpnagglga iaigvggada vdaltgtpwe lkapkilgvk ltgklngwst 241 pkdvitklag lltvrggtgy iveyfgegvs tlsctgmati cnmgaeigat tstfpyqeah 301 krylqatnra evaeaadval nkfnflradk daqydkviei dlsaiephvn gpftpdlstp 361 isqyaekslk enwpqkvsag ligsctnssy qdmsrvvdlv kqaskaglkp ripffvtpgs 421 eqiratlerd giidifqeng akvlanacgp cigqwnredv sktsketnti ftsfnrnfra 481 rndgnrntmn fltspeivta msysgdaqfn pltdsiklpn gkdfkfqppk gdelpkrgfe 541 hgrdkfypem dpkpdsnvei kvdpnsdrlq llepfkpwng kelktnvllk vegkcttdhi 601 saagvwlkyk ghlenisynt ligaqnketg evnkaydldg teydipglmm kwksdgrpwt 661 viaehnygeg sarehaalsp rflggeillv ksfarihetn lkkqgvlplt fanesdydki 721 ssgdvletln lvdmiakdgn nggeidvkit kpngesftik akhtmskdqi dffkagsain 781 yignirrne // LOCUS NP_001335786 108 aa linear PLN 30-JUN-2025 DEFINITION Mbb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335786 VERSION NP_001335786.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348846.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 108) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80306. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..108 /product="Mbb1p" /calculated_mol_wt="12391" CDS 1..108 /gene="MBB1" /locus_tag="YJL199C" /coded_by="NM_001348846.1:1..327" /note="hypothetical protein; conserved among S. cerevisiae strains, not conserved in closely related Saccharomyces species; protein detected via large-scale protein-protein interaction studies and enrichment-based proteogenomics; YJL199C is not an essential gene" /db_xref="GeneID:853240" /db_xref="SGD:S000003735" ORIGIN 1 mykvsacgvr imsgiseiwi gelrdykyal rldreeypav lvyeydssst rnylftikys 61 dqrpnwqlit rdaaltaydl lnrggefttl sfpgatihrs vselsrlh // LOCUS NP_012337 881 aa linear PLN 30-JUN-2025 DEFINITION SPX domain-containing inorganic phosphate transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_012337 VERSION NP_012337.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181631.1 REFERENCE 1 (residues 1 to 881) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 881) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 881) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 881) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08610. Method: conceptual translation. FEATURES Location/Qualifiers source 1..881 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..881 /product="SPX domain-containing inorganic phosphate transporter" /calculated_mol_wt="97558" Region 1..288 /region_name="COG5408" /note="SPX domain-containing protein [Signal transduction mechanisms]" /db_xref="CDD:227695" Region 442..870 /region_name="SLC13_permease" /note="Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; cd01115" /db_xref="CDD:238535" Site order(449..452,459..472,499..516,540..556,558..575, 582..605,627,629..642,670..682,690..704,719..737,762..777, 797..816,852..864) /site_type="other" /note="transmembrane helices" /db_xref="CDD:238535" CDS 1..881 /gene="PHO90" /locus_tag="YJL198W" /coded_by="NM_001181631.1:1..2646" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21143198]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0005315 phosphate transmembrane transporter activity [PMID:11779791]" /experiment="EXISTENCE:genetic interaction:GO:0006817 phosphate ion transport [PMID:11779791]" /experiment="EXISTENCE:genetic interaction:GO:2000185 regulation of phosphate transmembrane transport [PMID:12821119]" /experiment="EXISTENCE:mutant phenotype:GO:0005315 phosphate transmembrane transporter activity [PMID:12581367]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:17804816]" /note="Low-affinity phosphate transporter; acts upstream of Pho81p in regulation of the PHO pathway; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth; PHO90 has a paralog, PHO87, that arose from the whole genome duplication" /db_xref="GeneID:853241" /db_xref="SGD:S000003734" ORIGIN 1 mrfshflkyn avpewqnhym dyselknliy tlqtdelqvg dneegfgagk ssnitdrfkn 61 kfsfknaked tssgmnkdag iveetielre lptaqtvaak pspfrrmkek ifykrrsssa 121 ssvsstanen lqldtydtfv gdltaekqkv ddfykrteak fydkfdalvk dlkkigviey 181 didddtlfne piastndevp pldldddedd defyddqsni edntallhhs qyniksqkks 241 llkksivnly idlcqlksfi elnrigfaki tkksdkvlhl ntrteliese qffkdtyafq 301 aetiellnsk isqlvtfyar itdrphnish skqelksylh dhivwersnt wkdmlgllsq 361 adeltpkete ynanklvgkl dleyyrwplp rpinlkftsi nnvalpklff tkkaykiyfi 421 ilvtglllgi ktfndaaqhr cmalvecvaf lwaseaiplh itaflvpllv vlfkvlktsd 481 gaimsaasas seilaamwss timillagft lgevlaqyni akvlaswlla fagckprnvl 541 lmamcvvffl smwisnvaap vltysllspl ldamdadspf aqalvlgval aaniggmssp 601 isspqniism sylkpygigw gqffavalps gilamllvwi llfttfkmnk tklekfkpik 661 tkftvkqyyi itvtvatill wcvesqiega fgssgqiaii pivlffgtgl lstqdlnafp 721 wsivilamgg ialgkavsss gllstiakal qkkiendgvf ailcifgilm lvvgtfvsht 781 vsaiiiiplv qevgdklgnp kaapilvfgc allsscgmgl assgfpnvta iskvdrkgdr 841 ylsvmtfltr gvpasilafl cvitlgygim asvvkgnats a // LOCUS NP_012338 1254 aa linear PLN 30-JUN-2025 DEFINITION putative ubiquitin-specific protease UBP12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012338 VERSION NP_012338.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181630.1 REFERENCE 1 (residues 1 to 1254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1254) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08611. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1254 /product="putative ubiquitin-specific protease UBP12" /EC_number="3.4.19.12" /calculated_mol_wt="143062" Region 99..1111 /region_name="UBP12" /note="Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]; COG5560" /db_xref="CDD:227847" CDS 1..1254 /gene="UBP12" /locus_tag="YJL197W" /coded_by="NM_001181630.1:1..3765" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:29309037]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:31665643]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:31665643]" /experiment="EXISTENCE:genetic interaction:GO:0016579 protein deubiquitination [PMID:31665643]" /experiment="EXISTENCE:mutant phenotype:GO:0010637 negative regulation of mitochondrial fusion [PMID:23317502]" /experiment="EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:29309037|PMID:23317502]" /note="Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm" /db_xref="GeneID:853242" /db_xref="SGD:S000003733" ORIGIN 1 mgssdvssre cslvynedpd ftdgttpcdr lgvdlmnvld dkdeikqesv pvsdreiedt 61 esdasavssf asaneliaep haasetnlgt ngqdgrnvle qqrdvvarli eenketqkeg 121 dkvcivpkvw ydkffdpdvt dpedigpint rmicrdfenf vledynrcpy lsiaepvfnf 181 lseiygmtsg sypvvtnlvi nqttgelete ynkwffrlhy ltekqdgrkr rhgqddsimy 241 lsmsalnlvr dlveksmnlf fekadhldvn avdfkiwfvs egsdiatdsn vstflnssye 301 itplqflelp ikkllipdmf enrldkitsn psdlvieikp iegnhhwpsn yfaynklepa 361 sgttglvnlg ntcymnsalq clvhipqlrd yflydgyede ineenplgyh gyvarafsdl 421 vqklfqnrms imqrnaafpp smfkstighf nsmfsgymqq dsqeflafll dslhedlnri 481 ikkeytekps lspgddvndw nvvkkladdt wemhlkrncs vitdlfvgmy kstlycpecq 541 nvsitfdpyn dvtlplpvdt vwdktikifp mnspplllev elsksstymd lknyvgkmsg 601 ldpntlfgce ifsnqiyvny estesnaqfl tlqelikpad dvifyelpvt ndnevivpvl 661 ntriekgykn amlfgvpffi tlkedelnnp gairmklqnr fvhlsggyip fpepvgnrtd 721 fadafpllve kypdvefeqy kdilqytsik vtdkdksffs ikilsvekeq qfasnnrtgp 781 nfwtpisqln ldkatdiddk ledvvkdiyn ysslvdcaeg vlmqvddegd tegseaknfs 841 kpfqsgddee nketvtnnen vnntndrded meltddveed astepeltdk pealdkikds 901 ltstpfails mndiivcews elgsneafsd dkiynwenpa tlpnkelena klersnaker 961 titlddclql fskpeilglt dswycptcke hrqatkqiql wntpdillih lkrfesqrsf 1021 sdkidatvnf pitdldlsry vvykddprgl iydlyavdnh ygglggghyt ayvknfadnk 1081 wyyfddsrvt etapensiag sayllfyirr hkdgnglgss klqeiiqksr hgyderikki 1141 ydeqmklyef nktdeeedvs ddmiecnedv qapeysnrsl evghietqdc ndeddnddge 1201 rtnsgrrklr llkkvyknns glgssstsei segcpeneva dlnlkngvtl espe // LOCUS NP_012339 310 aa linear PLN 30-JUN-2025 DEFINITION fatty acid elongase ELO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012339 VERSION NP_012339.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181629.1 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 310) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08612. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..310 /product="fatty acid elongase ELO1" /EC_number="2.3.1.199" /calculated_mol_wt="36103" Region 58..303 /region_name="ELO" /note="GNS1/SUR4 family; pfam01151" /db_xref="CDD:460083" CDS 1..310 /gene="ELO1" /locus_tag="YJL196C" /coded_by="NM_001181629.1:1..933" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0009922 fatty acid elongase activity [PMID:12684876]" /experiment="EXISTENCE:mutant phenotype:GO:0019368 fatty acid elongation, unsaturated fatty acid [PMID:10850979]" /note="Elongase I, medium-chain acyl elongase; catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids; ELO1 has a paralog, ELO2, that arose from the whole genome duplication" /db_xref="GeneID:853243" /db_xref="SGD:S000003732" ORIGIN 1 mvsdwknfcl ekasrfrpti drpffniylw dyfnravgwa tagrfqpkdf eftvgkqpls 61 eprpvllfia myyvvifggr slvksckplk lrfisqvhnl mltsvsflwl ilmveqmlpi 121 vyrhglyfav cnveswtqpm etlyylnymt kfvefadtvl mvlkhrkltf lhtyhhgata 181 llcynqlvgy tavtwvpvtl nlavhvlmyw yyflsasgir vwwkawvtrl qivqfmldli 241 vvyyvlyqki vaayfknact pqcedclgsm taiaagaail tsylflfisf yievykrgsa 301 sgkkkinknn // LOCUS NP_012341 513 aa linear PLN 30-JUN-2025 DEFINITION AAA family ATPase CDC6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012341 VERSION NP_012341.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181627.1 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 513) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08613. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..513 /product="AAA family ATPase CDC6" /calculated_mol_wt="57906" Region 78..472 /region_name="CDC6" /note="Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]; COG1474" /db_xref="CDD:441083" CDS 1..513 /gene="CDC6" /locus_tag="YJL194W" /coded_by="NM_001181627.1:1..1542" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:9288745|PMID:9159120]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:9288745|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8083240]" /experiment="EXISTENCE:direct assay:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:8930895]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:8083240]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:8083240]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:8083240]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:8930895]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10075735]" /experiment="EXISTENCE:mutant phenotype:GO:0003682 chromatin binding [PMID:10075735]" /experiment="EXISTENCE:mutant phenotype:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:11460169]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:10075735]" /experiment="EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:8538771|PMID:23376927|PMID:9335335|PMID:10075735]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:9990508]" /experiment="EXISTENCE:mutant phenotype:GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity [PMID:11460169]" /experiment="EXISTENCE:mutant phenotype:GO:0140530 MCM complex loading [PMID:29795547]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10075735|PMID:9312054]" /note="Essential ATP-binding protein required for DNA replication; component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; dual role as a mitotic cyclin-dependent kinase inhibitor, that binds to and inhibits Cdc28p/Clb2p along with Sic1p, contributing to mitotic exit; homologous to S. pombe Cdc18p; relocalizes from nucleus to cytoplasm upon DNA replication stress; degraded in response to plasma membrane stress" /db_xref="GeneID:853244" /db_xref="SGD:S000003730" ORIGIN 1 msaipitptk rirrnlfdda patpprplkr kklqftdvtp esspeklqfg sqsiflrtka 61 llqksselvn lnssdgalpa rtaeyeqvmn flakaisehr sdslyitgpp gtgktaqldm 121 iirqkfqslp lslstprskd vlrhtnpnlq nlswfelpdg rlesvavtsi ncislgepss 181 ifqkifdsfq dlngptlqik nmqhlqkfle pyhkkttfvv vldemdrllh antsetqsvr 241 tilelfllak lptvsfvlig mansldmkdr flsrlnldrg llpqtivfqp ytaeqmyeiv 301 iqkmsslpti ifqpmaikfa akkcagntgd lrklfdvlrg sieiyelekr fllsptrgsl 361 nsaqvpltpt tspvkksype pqgkiglnyi akvfskfvnn nstrtriakl niqqklilct 421 iiqslklnsd atidesfdhy ikaitktdtl aplqrnefle ictiletcgl vsikktkckg 481 ktkrfvdkid vdldmrefyd emtkisilkp flh // LOCUS NP_012342 402 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL193W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012342 VERSION NP_012342.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181626.1 REFERENCE 1 (residues 1 to 402) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 402) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 402) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 402) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08614. Method: conceptual translation. FEATURES Location/Qualifiers source 1..402 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..402 /product="uncharacterized protein" /calculated_mol_wt="45806" Region 112..398 /region_name="TPT" /note="Triose-phosphate Transporter family; cl26744" /db_xref="CDD:474852" CDS 1..402 /locus_tag="YJL193W" /coded_by="NM_001181626.1:1..1209" /note="hypothetical protein; predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect" /db_xref="GeneID:853246" /db_xref="SGD:S000003729" ORIGIN 1 mfqqlsasir hnahiiflci swyfisslas qvtkqvltvc plplflgefq fiytavlawf 61 tcyiaysfpg fyrifpngtf peyyiddret sraarkeskl ssliippskp ilqtvlplgl 121 fqfvgkyfgh tatslvpvst vasiktlspm filllqkilk istlkitltl ifslctlvlg 181 vwiivqednr spassnelre fskygvicam ismfifvlqn iygktvftyr sqtdesqsns 241 gfsrqesplp lyekldeklv akkkpksydk ltlmiyislv gfclsfgwfi tlefpvlfry 301 ffqinssstv ikafpvslfl lngtfhfiqa mitfhllgev stltysianl mkrfaiiavs 361 wvfigrritw lqvfglvlnt lglflyerct sqskikakir pe // LOCUS NP_012343 234 aa linear PLN 30-JUN-2025 DEFINITION Sop4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012343 VERSION NP_012343.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181625.1 REFERENCE 1 (residues 1 to 234) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 234) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 234) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 234) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08615. Method: conceptual translation. FEATURES Location/Qualifiers source 1..234 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..234 /product="Sop4p" /calculated_mol_wt="26467" Region 24..227 /region_name="SOP4" /note="Suppressor of PMA 1-7 protein; pfam17081" /db_xref="CDD:407234" CDS 1..234 /gene="SOP4" /locus_tag="YJL192C" /gene_synonym="EMC7" /coded_by="NM_001181625.1:1..705" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:12230471]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:12230471]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:12230471]" /note="ER-membrane protein; subunit of evolutionarily conserved EMC (Endoplasmic Reticulum Membrane Complex) implicated in ERAD (ER-associated degradation) and proper assembly of multi-pass transmembrane (TM) proteins; EMC acts in yeast as an ER-mitochondria tether that interacts with outer membrane protein Tom5 of TOM (Translocase of the Mitochondrial Outer Membrane) complex; suppressor of pma1-7, deletion of SOP4 slows down export of wild-type Pma1p and Pma1-7 from the ER" /db_xref="GeneID:853247" /db_xref="SGD:S000003728" ORIGIN 1 mfsqivllls afiyvasata rrgtikgrld laasnitgfv strtsfklyq ignfsteypy 61 tsttmfqdde gnfefanlpl ndgvnettyy vmypasmdfn lkpnrilief knlengtlql 121 nafknffgre yfpskdityp eklqsmkvhp yitvellhka pirsylqarn vsifstgivg 181 nilnsrwkla gvitlialvv fpiivekldp etaraireea krkqrekyaa vask // LOCUS NP_012344 138 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS11 RPS14B [Saccharomyces cerevisiae S288C]. ACCESSION NP_012344 VERSION NP_012344.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181624.1 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 138) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08616. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..138 /product="40S ribosomal protein uS11 RPS14B" /calculated_mol_wt="14519" Region 7..127 /region_name="PTZ00129" /note="40S ribosomal protein S14; Provisional" /db_xref="CDD:185465" CDS 1..138 /gene="RPS14B" /locus_tag="YJL191W" /gene_synonym="CRY2" /coded_by="NM_001181624.1:1..417" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:9858605]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:2277060]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15125836]" /note="Protein component of the small (40S) ribosomal subunit; required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; homologous to mammalian ribosomal protein S14 and bacterial S11; RPS14B has a paralog, RPS14A, that arose from the whole genome duplication" /db_xref="GeneID:853248" /db_xref="SGD:S000003727" ORIGIN 1 mandlvqard nsqvfgvari yasfndtfvh vtdlsgketi arvtggmkvk adrdesspya 61 amlaaqdvaa kckevgitav hvkiratggt rtktpgpggq aalralarsg lrigriedvt 121 pvpsdstrkk ggrrgrrl // LOCUS NP_012345 130 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS8 RPS22A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012345 VERSION NP_012345.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181623.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 130) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08617. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..130 /product="40S ribosomal protein uS8 RPS22A" /calculated_mol_wt="14495" Region 1..130 /region_name="PTZ00158" /note="40S ribosomal protein S15A; Provisional" /db_xref="CDD:185487" CDS 1..130 /gene="RPS22A" /locus_tag="YJL190C" /gene_synonym="RPS24" /coded_by="NM_001181623.1:1..393" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22A has a paralog, RPS22B, that arose from the whole genome duplication" /db_xref="GeneID:853249" /db_xref="SGD:S000003726" ORIGIN 1 mtrssvlada lnainnaekt gkrqvlirps skviikflqv mqkhgyigef eyiddhrsgk 61 ivvqlngrln kcgvisprfn vkigdiekwt anllparqfg yvilttsagi mdheearrkh 121 vsgkilgfvy // LOCUS NP_012346 51 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL39 RPL39 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012346 VERSION NP_012346.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181622.1 REFERENCE 1 (residues 1 to 51) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 51) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 51) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 51) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08618. Method: conceptual translation. FEATURES Location/Qualifiers source 1..51 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..51 /product="60S ribosomal protein eL39 RPL39" /calculated_mol_wt="6210" Region <20..50 /region_name="Ribosomal_L39" /note="Ribosomal L39 protein; pfam00832" /db_xref="CDD:425894" CDS 1..51 /gene="RPL39" /locus_tag="YJL189W" /gene_synonym="RPL46; SPB2" /coded_by="NM_001181622.1:1..156" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L39; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1; homologous to mammalian ribosomal protein L39, no bacterial homolog" /db_xref="GeneID:853250" /db_xref="SGD:S000003725" ORIGIN 1 maaqksfrik qkmakakkqn rplpqwirlr tnntirynak rrnwrrtkmn i // LOCUS NP_012348 819 aa linear PLN 30-JUN-2025 DEFINITION tyrosine protein kinase SWE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012348 VERSION NP_012348.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181620.1 REFERENCE 1 (residues 1 to 819) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 819) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 819) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 819) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 819) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 819) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 819) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08619. Method: conceptual translation. FEATURES Location/Qualifiers source 1..819 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..819 /product="tyrosine protein kinase SWE1" /EC_number="2.7.11.1" /calculated_mol_wt="92337" Region 443..791 /region_name="PTKc_Wee1_fungi" /note="Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; cd14052" /db_xref="CDD:270954" Site order(450..454,458,471,473,511,527..530,534,536,579,581, 583..584,586,597,600,615..618) /site_type="active" /db_xref="CDD:270954" Site order(450..454,458,471,473,511,527..530,534,579,581, 583..584,586,597) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270954" Site order(454,534,536,579,581,583,600,615..618) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270954" Site order(596..605,609..618) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270954" CDS 1..819 /gene="SWE1" /locus_tag="YJL187C" /gene_synonym="WEE1" /coded_by="NM_001181620.1:1..2460" /experiment="EXISTENCE:direct assay:GO:0000086 G2/M transition of mitotic cell cycle [PMID:8253069]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004713 protein tyrosine kinase activity [PMID:8253069]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802|PMID:10805747]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10805747|PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:8930890]" /experiment="EXISTENCE:genetic interaction:GO:0000320 re-entry into mitotic cell cycle [PMID:15107621]" /experiment="EXISTENCE:genetic interaction:GO:0010697 negative regulation of mitotic spindle pole body separation [PMID:8887667]" /experiment="EXISTENCE:genetic interaction:GO:0090154 positive regulation of sphingolipid biosynthetic process [PMID:26634277]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:8253069]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0010697 negative regulation of mitotic spindle pole body separation [PMID:8887667]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:10619027]" /experiment="EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:9744879]" /experiment="EXISTENCE:mutant phenotype:GO:0090154 positive regulation of sphingolipid biosynthetic process [PMID:26634277]" /note="Protein kinase that regulates the G2/M transition; negative regulator of the Cdc28p kinase; morphogenesis checkpoint kinase; positive regulator of sphingolipid biosynthesis via Orm2p; phosphorylates a tyrosine residue in the N-terminus of Hsp90 in a cell-cycle associated manner, thus modulating the ability of Hsp90 to chaperone a selected clientele; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate" /db_xref="GeneID:853252" /db_xref="SGD:S000003723" ORIGIN 1 mssldedeed femldtenlq fmgkkmfgkq agedesddfa iggstptnkl kfypysnnkl 61 trstgtlnls lsntalsean skflgkieee eeeeeegkde esvdsrikrw spfhenesvt 121 tpitkrsaek tnspislkqw nqrwfpknda rtentsssss ysvakpnqsa ftssglvskm 181 smdtslypak lripetpvkk splvegrdhk hvhlssskna ssslsvspln fvednnlqed 241 llfsdspssk alpsihvpti dssplseaky hahdrhnnqt nilsptnslv tnsspqtlhs 301 nkfkkikrar nsvilknrel tnslqqfkdd lygtdenfpp piiisshhst rknpqpyqfr 361 grydndtdee istptrrksi igatsqthre srplslssai vtnttsaeth sisstdsspl 421 nskrrlissn klsanpdshl fekftnvhsi gkgqfstvyq vtfaqtnkky aikaikpnky 481 nslkrillei kilnevtnqi tmdqegkeyi idyisswkfq nsyyimtelc engnldgflq 541 eqviakkkrl edwriwkiiv elslalrfih dschivhldl kpanvmitfe gnlklgdfgm 601 athlpledks fenegdreyi apeiisdcty dykadifslg lmiveiaanv vlpdngnawh 661 klrsgdlsda grlsstdihs eslfsditkv dtndlfdfer dnisgnsnna gtstvhnnsn 721 innpnmnngn dnnnvntaat knrlilhkss kipawvpkfl idgesleriv rwmiepnyer 781 rptanqilqt eeclyvemtr nagaiiqedd fgpkpkffi // LOCUS NP_012349 586 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,2-mannosyltransferase MNN5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012349 VERSION NP_012349.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181619.2 REFERENCE 1 (residues 1 to 586) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 586) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 586) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 586) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08620. On Apr 26, 2011 this sequence version replaced NP_012349.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..586 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..586 /product="alpha-1,2-mannosyltransferase MNN5" /calculated_mol_wt="67073" Region 149..433 /region_name="Mannosyl_trans3" /note="Mannosyltransferase putative; pfam11051" /db_xref="CDD:402574" CDS 1..586 /gene="MNN5" /locus_tag="YJL186W" /coded_by="NM_001181619.2:1..1761" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:9756928]" /experiment="EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:9756928]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:9756928]" /note="Alpha-1,2-mannosyltransferase; responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment" /db_xref="GeneID:853253" /db_xref="SGD:S000003722" ORIGIN 1 mlirlkkrki lqvivsavvl ilffcsvhnd vssswlygkk lrlpvltrsn lknnfyttlv 61 qaivenkpad sspdlsklhg aegcsfannv aahdsghdsd lsyeslskcy nlnktvqesl 121 revhskftdt lsgklnfsip qrealfsgse givtigggky svlaytmikk lrdtgttlpi 181 eviippqdeg eddfcknwlp kfngkciyfs divpskplsd lklthfqlkv fgliissfkr 241 iifldadnya vknldlafnt tsfndtglil wpdfwrrvtp pafyniigss inigkrvrfv 301 sddispvsry dpfvsnsndy tpkerqehfl khvplhdldg tmpdlssesg qmvidkirhf 361 ntlllalyyn vygptwyykm isqgtagegd kdtfvaaaha lnmpyyqvrt nfefdgffyq 421 kddykglall qhdfeqdykq yqkaqqkvka nieefskldp dytldngflk tlmvnddgsd 481 ldimfihasf ykadpwtlyh enrfigpnge qvrgfrkphr ygmdfelflf ndmrgsfctt 541 pksqvikfky ftdkvntpew damceyltnh vnylesthke amgekn // LOCUS NP_012350 293 aa linear PLN 30-JUN-2025 DEFINITION Atg36p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012350 VERSION NP_012350.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181618.1 REFERENCE 1 (residues 1 to 293) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 293) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 293) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 293) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08621. Method: conceptual translation. FEATURES Location/Qualifiers source 1..293 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..293 /product="Atg36p" /calculated_mol_wt="33609" CDS 1..293 /gene="ATG36" /locus_tag="YJL185C" /coded_by="NM_001181618.1:1..882" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:22643220]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:29673596]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:22643220]" /experiment="EXISTENCE:physical interaction:GO:0000425 pexophagy [PMID:22643220]" /note="Pex3p interacting protein, required for pexophagy; interacts with Atg8p and Atg11p; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene" /db_xref="GeneID:853254" /db_xref="SGD:S000003721" ORIGIN 1 masvnnyqvd cgsrsariqp rinngihdee slfevlelse eefeldfhrl ksfndvrvin 61 npdlspectn taisrdetle sassafevps deiailsiss dsnknsppse qpapalrnir 121 sssnsdride wclgshlfne lhqnvpqssd gvnhgfpvys fkerelytsa klkkltnaqr 181 iavqklsrdl ypilrtcyre ktrrqlltyh herifddips ffpqrdfifn yysmplefdr 241 lsdvdidsss rsrftdestg etlnrspsaa ssslentswf gwtllsrfld rew // LOCUS NP_012351 123 aa linear PLN 30-JUN-2025 DEFINITION chromatin DNA-binding EKC/KEOPS complex subunit GON7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012351 VERSION NP_012351.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181617.1 REFERENCE 1 (residues 1 to 123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 123) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08622. Method: conceptual translation. FEATURES Location/Qualifiers source 1..123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..123 /product="chromatin DNA-binding EKC/KEOPS complex subunit GON7" /calculated_mol_wt="13474" Region 4..110 /region_name="Gon7" /note="Gon7 family; pfam08738" /db_xref="CDD:370092" CDS 1..123 /gene="GON7" /locus_tag="YJL184W" /gene_synonym="LDB6; PCC2" /coded_by="NM_001181617.1:1..372" /experiment="EXISTENCE:direct assay:GO:0000408 EKC/KEOPS complex [PMID:16564010|PMID:16874308]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16874308]" /experiment="EXISTENCE:direct assay:GO:0031490 chromatin DNA binding [PMID:16874308]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:14734024]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:16564010]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16874308]" /note="Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; implicated in osmotic stress response; other complex members are Kae1p, Cgi121p, Pcc1p, and Bud32p" /db_xref="GeneID:853255" /db_xref="SGD:S000003720" ORIGIN 1 mklpvaqysa pdgveksfap irddprymtt egrttgpsdh vlnagqidrd kpsepertkd 61 gsqltylgql rtqltglqdd inefltgrme laknkkkaga dekriqeein qlldggdgde 121 dav // LOCUS NP_012352 422 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012352 VERSION NP_012352.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181616.2 REFERENCE 1 (residues 1 to 422) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 422) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 422) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 422) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08623. On Apr 26, 2011 this sequence version replaced NP_012352.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..422 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..422 /product="alpha-1,6-mannosyltransferase" /calculated_mol_wt="47728" Region 156..408 /region_name="Glyco_transf_34" /note="galactosyl transferase GMA12/MNN10 family; pfam05637" /db_xref="CDD:368535" CDS 1..422 /gene="MNN11" /locus_tag="YJL183W" /coded_by="NM_001181616.2:1..1269" /experiment="EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:10635561]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006486 protein glycosylation [PMID:10635561]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:10635561]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:23210626]" /experiment="EXISTENCE:physical interaction:GO:0000136 mannan polymerase complex [PMID:9430634]" /note="Subunit of a Golgi mannosyltransferase complex; this complex also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p" /db_xref="GeneID:853256" /db_xref="SGD:S000003719" ORIGIN 1 maikprtkgk tyssrsvgsq wfnrlgfkqn kygtckflsi itafvfilyf fsnrfypisr 61 sagasyspsh glyineipas srliyphveh vpvlkqmtvr glyitrlevd gskrlilkpe 121 enaltdeekk kttdqillvk hsfldhgklv yrksndapev vvvtlidfen yeletiiqiv 181 qnrvdyaqkh qygvyirwiq eflpvlenqn laesyefikp lviraamhaf ptakyihfvd 241 qdallmnldl slqkylldpk imdlallknv pvvansnikt ynhfeyssak iiiphdadgn 301 idassfvian dfygkalidy lndpllrnfp wdntgdklsa aighilqwhp tllgktaivi 361 pkvlasqyda sldqegesgn gasngdvyhy negdlaasfk gcrsrgtcas eighmyqkik 421 ks // LOCUS NP_012354 611 aa linear PLN 30-JUN-2025 DEFINITION Rbh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012354 VERSION NP_012354.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181614.1 REFERENCE 1 (residues 1 to 611) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 611) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 611) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 611) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08624. Method: conceptual translation. FEATURES Location/Qualifiers source 1..611 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..611 /product="Rbh1p" /calculated_mol_wt="69346" CDS 1..611 /gene="RBH1" /locus_tag="YJL181W" /coded_by="NM_001181614.1:1..1836" /note="hypothetical protein; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region; contains a PH-like domain; RBH1 has a paralog, RBH2, that arose from the whole genome duplication" /db_xref="GeneID:853257" /db_xref="SGD:S000003717" ORIGIN 1 meifkeeeee afsaiegiiy acevydpvpr hlhksktkii naakliieth lsyytilnni 61 sdiqaylstw lrdlgttgpy qtilsesisl mfdrtvsifr kctieggfph liarlylrlk 121 syqkllndag lknffssydy afgvaynlvn cseyrydevh yisngtyslv asmkidpaev 181 ikrehfrlti pkfnisnili eifhlldgla ffkvnpdsls istasaetif rsisegnhqv 241 lelgrslmfp llrtgdfeic riddagavit fteakdvkle iisldevswv mqwksclqny 301 erraandssf ikthlqfkka nnfnednngl glivdrnipt ddftlastnr qspppsntgc 361 slhrskplhi plssviredf ydsslneris kdgdsscesf sgaesilsdy dfhdneffnn 421 qsphyfsehi dnnsrevvit dentiislen tqvsrwsnys wqkisphqlq vsiiqlrmgn 481 fivaydsdyn lhqfkirlcd dikciqsteq diqirvplga imcsvtgiln irtkdadkll 541 rvlsfyttdh teavshsnnq datasplssv ssamdlkhsl qkcsstimpq eltqdvigsk 601 sdlisnirqk i // LOCUS NP_012355 325 aa linear PLN 30-JUN-2025 DEFINITION ATP synthase complex assembly protein ATP12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012355 VERSION NP_012355.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181613.1 REFERENCE 1 (residues 1 to 325) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 325) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 325) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 325) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08625. Method: conceptual translation. FEATURES Location/Qualifiers source 1..325 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..325 /product="ATP synthase complex assembly protein ATP12" /calculated_mol_wt="36423" Region 53..193 /region_name="ATP12" /note="ATP12 chaperone protein; pfam07542" /db_xref="CDD:462201" CDS 1..325 /gene="ATP12" /locus_tag="YJL180C" /coded_by="NM_001181613.1:1..978" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:1826907]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:2142305]" /experiment="EXISTENCE:physical interaction:GO:0019904 protein domain specific binding [PMID:10747017]" /experiment="EXISTENCE:physical interaction:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:10747017]" /note="Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase; conserved protein; required for assembly of alpha and beta subunits into F1 sector of mitochondrial F1F0 ATP synthase; human homolog ATPAF2 can complement yeast atp12 mutant; mutation of human homolog reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency" /db_xref="GeneID:853259" /db_xref="SGD:S000003716" ORIGIN 1 mlpslrkgcf ivnsirlklp rfyslnaqpl gtdntiennt ptetnrlskt sqkfwekvsl 61 nrdvekgkia lqldgrtikt plgngiivdn aksllayllk lewsslssls ikthslplts 121 lvarcidlqm tnepgcdpql vakiggnsdv iknqllryld tdtllvfspm nefegrlrna 181 qnelyipiik gmeeflrnfs sesnirlqil dadihglrgn qqsdivknaa kkymsslspw 241 dlailektvl ttksficgvl llenkkdtan lipalktdmd nivraatlet ifqvekwgev 301 edthdvdkrd irrkihtaai aafkq // LOCUS NP_012356 109 aa linear PLN 30-JUN-2025 DEFINITION prefolding complex chaperone subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_012356 VERSION NP_012356.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181612.2 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 109) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08626. On Apr 26, 2011 this sequence version replaced NP_012356.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..109 /product="prefolding complex chaperone subunit" /calculated_mol_wt="12651" Region 18..104 /region_name="Prefoldin" /note="prefoldin; cl09111" /db_xref="CDD:471851" Region 18..45 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467470" Region 65..94 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467470" CDS 1..109 /gene="PFD1" /locus_tag="YJL179W" /gene_synonym="GIM6" /coded_by="NM_001181612.2:1..330" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9630229]" /experiment="EXISTENCE:mutant phenotype:GO:0007010 cytoskeleton organization [PMID:9630229]" /experiment="EXISTENCE:mutant phenotype:GO:0016272 prefoldin complex [PMID:9630229]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:9630229]" /note="Subunit of heterohexameric prefoldin; prefoldin binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation" /db_xref="GeneID:853260" /db_xref="SGD:S000003715" ORIGIN 1 msqiaqemtv slrnartqld mvnqqlayld rqeklaeltk kelesyptdk vwrscgksfi 61 lqdkskyvnd lshdetvlld qrktlkikkn ylettvekti dnlkalmkn // LOCUS NP_012357 271 aa linear PLN 30-JUN-2025 DEFINITION Atg27p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012357 VERSION NP_012357.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181611.1 REFERENCE 1 (residues 1 to 271) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 271) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 271) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 271) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08627. On Feb 23, 2004 this sequence version replaced NP_012357.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..271 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..271 /product="Atg27p" /calculated_mol_wt="30070" Region 4..267 /region_name="ATG27" /note="Autophagy-related protein 27; pfam09451" /db_xref="CDD:430622" CDS 1..271 /gene="ATG27" /locus_tag="YJL178C" /gene_synonym="ETF1" /coded_by="NM_001181611.1:1..816" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:17135291]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17135291]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:25557545]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16107716]" /experiment="EXISTENCE:direct assay:GO:0016236 macroautophagy [PMID:25557545]" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:33817564]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:12186856]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:17135291]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:17135291]" /experiment="EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:12186856]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:17135291]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:17135291]" /note="Type I membrane protein involved in autophagy and the Cvt pathway; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:853261" /db_xref="SGD:S000003714" ORIGIN 1 mvsktwicgf isiitvvqal scekhdvlkk yqvgkfsslt sterdtppst tiekwwinvc 61 eehnveppee ckkndmlcgl tdvilpgkda ittqiidfdk nigfnveete saltltlkga 121 twgansfdak lefqcndnmk qdeltshtwa dksiqltlkg psgclkskdd dkkngdgdng 181 kdgdsegkkp akkaggtswf twlflyallf tliylmvvsf lntrggsfqd fraefiqrst 241 qfltslpefc kevvsrilgr staqrggysa v // LOCUS NP_012358 184 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL22 RPL17B [Saccharomyces cerevisiae S288C]. ACCESSION NP_012358 VERSION NP_012358.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181610.1 REFERENCE 1 (residues 1 to 184) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 184) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 184) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 184) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08628. Method: conceptual translation. FEATURES Location/Qualifiers source 1..184 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..184 /product="60S ribosomal protein uL22 RPL17B" /calculated_mol_wt="20420" Region 1..184 /region_name="PTZ00178" /note="60S ribosomal protein L17; Provisional" /db_xref="CDD:240306" Site order(15..16,38..40,42..43,45..46,99..104,112..117, 149..150) /site_type="active" /note="putative translocon binding site [active]" /db_xref="CDD:238205" Site order(18,20,23,25..27,30,34,37,97,101,104,116,118..120,122, 125,137..142) /site_type="other" /note="protein-rRNA interface [nucleotide binding]" /db_xref="CDD:238205" CDS 1..184 /gene="RPL17B" /locus_tag="YJL177W" /coded_by="NM_001181610.1:1..555" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23268442]" /experiment="EXISTENCE:genetic interaction:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23268442]" /note="Ribosomal 60S subunit protein L17B; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17B has a paralog, RPL17A, that arose from the whole genome duplication" /db_xref="GeneID:853262" /db_xref="SGD:S000003713" ORIGIN 1 marygatstn paksasargs ylrvsfkntr etaqaingwe ltkaqkyldq vldhqraipf 61 rrfnssigrt aqgkefgvtk arwpaksvkf vqgllqnaaa naeakgldat klyvshiqvn 121 qapkqrrrty rahgrinkye sspshielvv tekeeavaka aekkvvrlts rqrgriaaqk 181 risa // LOCUS NP_012359 825 aa linear PLN 30-JUN-2025 DEFINITION Swi3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012359 VERSION NP_012359.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181609.1 REFERENCE 1 (residues 1 to 825) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 825) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 825) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 825) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08629. Method: conceptual translation. FEATURES Location/Qualifiers source 1..825 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..825 /product="Swi3p" /calculated_mol_wt="92796" Region 253..825 /region_name="RSC8" /note="RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]; COG5259" /db_xref="CDD:227584" CDS 1..825 /gene="SWI3" /locus_tag="YJL176C" /gene_synonym="HAF2; TYE2" /coded_by="NM_001181609.1:1..2478" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16461455]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1339306|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:8016655]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:8159677|PMID:8127913|PMID:8016655|PMID:18644858]" /experiment="EXISTENCE:mutant phenotype:GO:0003677 DNA binding [PMID:16461455]" /experiment="EXISTENCE:mutant phenotype:GO:0016514 SWI/SNF complex [PMID:8159677]" /experiment="EXISTENCE:mutant phenotype:GO:0031496 positive regulation of mating type switching [PMID:6436497]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3542227|PMID:1339306]" /experiment="EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:17496903]" /note="Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions" /db_xref="GeneID:853264" /db_xref="SGD:S000003712" ORIGIN 1 mentlgegst vnasvdvdqh gndnnsdsna naavagvant dtageesqqq deslkdeatv 61 pntrdaesea itvtakqqpt mqankldsqe tpsteesraq nvfgqdneds dnlfgetess 121 vsnneantps iptnpvdnen nkpaikedst iqdsngdvkn medvkiqkee epenntvieg 181 vkeesqpden tkemdeveed dedddqpmis pdnsifgdtk seskqlgnts svantpseip 241 dahkaeqedi iektesvdkk vdsgeerneq ereimndhsk sanpkkttit rvepetfeip 301 qaheivipsy skwfnlekih sievqslpef ftnripsktp evymryrnfm vnsyrlnpne 361 yfsvttarrn vsgdaaalfr lhkfltkwgl inyqvdskll pkniepplts qystrhdapr 421 glfpfesykp svqlpdmakl kkmmntsdse stlykylkes krkydeithp psttddengd 481 kndnggkmnn evststsmtg danlleeget srplkkvkil eqidenwske dlqkllkgiq 541 efgadwykva knvgnkspeq cilrflqlpi edkflygdgn gkgdndnglg plkyaphlpf 601 sksenpvlst iaflvglvnp ktvqsmtqra iqsaesiksq keeisdqkpi ehikegseia 661 isslgyrshi fatneerqmn fltnelirlq mekldaklnh lkklekfmel erktlerqqe 721 nlliqrlnfn qnsskivnvl skclnlisds ninnssvaek eeirsqidhf ksmlskpetl 781 sigknpfnkp nietgenhng qsisnendvk pisieapqfy rywsa // LOCUS NP_012361 276 aa linear PLN 30-JUN-2025 DEFINITION Kre9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012361 VERSION NP_012361.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181607.1 REFERENCE 1 (residues 1 to 276) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 276) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 276) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 276) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08630. Method: conceptual translation. FEATURES Location/Qualifiers source 1..276 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..276 /product="Kre9p" /calculated_mol_wt="29858" Region 27..133 /region_name="Kre9_KNH" /note="Kre9/KNH-like N-terminal Ig-like domain; pfam10342" /db_xref="CDD:463051" Region 173..273 /region_name="Kre9_KNH1_C" /note="Yeast cell wall synthesis protein KRE9/KNH1 C-terminal; pfam05390" /db_xref="CDD:398842" CDS 1..276 /gene="KRE9" /locus_tag="YJL174W" /coded_by="NM_001181607.1:1..831" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:8413233]" /experiment="EXISTENCE:mutant phenotype:GO:0006077 (1->6)-beta-D-glucan metabolic process [PMID:8413233]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:8413233]" /note="Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects" /db_xref="GeneID:853265" /db_xref="SGD:S000003710" ORIGIN 1 mrlqrnsiic alvflvsfvl gdvnivspss katfspsggt vsvpvewmdn gaypslskis 61 tftfslctgp nnnidcvavl askitpselt qddkvysyta efastltgng qyyiqvfaqv 121 dgqgytihyt prfqltsmgg vtaytysatt eptpqtsiqt tttnnaqatt idsrsftvpy 181 tkqtgtsrfa pmqmqpntkv tattwtrkfa tsavtyystf gslpeqatti tpgwsytiss 241 gvnyatpasm psdnggwykp skrlslsark inmrkv // LOCUS NP_012362 122 aa linear PLN 30-JUN-2025 DEFINITION Rfa3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012362 VERSION NP_012362.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181606.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 122) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08631. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..122 /product="Rfa3p" /calculated_mol_wt="13685" Region 1..122 /region_name="Rep_fac-A_3" /note="Replication factor A protein 3; pfam08661" /db_xref="CDD:462551" CDS 1..122 /gene="RFA3" /locus_tag="YJL173C" /gene_synonym="RPA14; RPA3" /coded_by="NM_001181606.1:1..369" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9679065]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:7761422]" /experiment="EXISTENCE:direct assay:GO:0005662 DNA replication factor A complex [PMID:2554144]" /experiment="EXISTENCE:direct assay:GO:0006260 DNA replication [PMID:2554144]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]" /experiment="EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:8910442]" /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:12226081]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:7761422]" /experiment="EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:9679065]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:14702040]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:9093844]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:9093844]" /experiment="EXISTENCE:mutant phenotype:GO:0010833 telomere maintenance via telomere lengthening [PMID:22354040]" /experiment="EXISTENCE:physical interaction:GO:0000722 telomere maintenance via recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0006312 mitotic recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0007004 telomere maintenance via telomerase [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0007131 reciprocal meiotic recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0016567 protein ubiquitination [PMID:18342608]" /experiment="EXISTENCE:physical interaction:GO:0045184 establishment of protein localization [PMID:2554144]" /note="Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853266" /db_xref="SGD:S000003709" ORIGIN 1 masetprvdp teisnvnapv friiaqiksq ptesqlilqs ptisskngse vemitlnnir 61 vsmnktfeid swyefvcrnn ddgelgflil davlckfken edlslngvva lqrlckkype 121 iy // LOCUS NP_012363 576 aa linear PLN 30-JUN-2025 DEFINITION Gly-Xaa carboxypeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012363 VERSION NP_012363.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181605.1 REFERENCE 1 (residues 1 to 576) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 576) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 576) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 576) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08632. Method: conceptual translation. FEATURES Location/Qualifiers source 1..576 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..576 /product="Gly-Xaa carboxypeptidase" /EC_number="3.4.17.4" /calculated_mol_wt="64466" Region 91..570 /region_name="M20_yscS" /note="M20 Peptidase, carboxypeptidase yscS; cd05674" /db_xref="CDD:349923" CDS 1..576 /gene="CPS1" /locus_tag="YJL172W" /coded_by="NM_001181605.1:1..1731" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:1569061]" /experiment="EXISTENCE:mutant phenotype:GO:0004180 carboxypeptidase activity [PMID:2026161]" /experiment="EXISTENCE:mutant phenotype:GO:0008152 metabolic process [PMID:2026161]" /experiment="EXISTENCE:mutant phenotype:GO:0051603 proteolysis involved in protein catabolic process [PMID:2026161]" /note="Vacuolar carboxypeptidase S; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via AP-3 pathway; expression induced under low-nitrogen conditions" /db_xref="GeneID:853267" /db_xref="SGD:S000003708" ORIGIN 1 mialpvekap rkslwqrhra fisgivalii igtffltsgl hpappheakr phhgkgpmhs 61 pkcekiepls psfkhsvdti lhdpafrnss ieklsnavri ptvvqdknpn paddpdfykh 121 fyelhdyfek tfpnihkhlk lekvnelgll ytwegsdpdl kplllmahqd vvpvnnetls 181 swkfppfsgh ydpetdfvwg rgsndcknll iaefeaieql lidgfkpnrt ivmslgfdee 241 asgtlgaasl asflherygd dgiysiideg egimevdkdv fvatpinaek gyvdfevsil 301 ghgghssvpp dhttigiase litefeanpf dyefefdnpi yglltcaaeh skslskdvkk 361 tilgapfcpr rkdklveyis nqshlrslir ttqavdiing gvkanalpet trflinhrin 421 lhssvaevfe rnieyakkia ekygyglskn gddyiipete lghiditllr elepaplsps 481 sgpvwdilag tiqdvfengv lqnneefyvt tglfsgntdt kyywnlskni yrfvgsiidi 541 dllktlhsvn ehvdvpghls aiafvyeyiv nvneya // LOCUS NP_012364 396 aa linear PLN 30-JUN-2025 DEFINITION Toh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012364 VERSION NP_012364.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181604.2 REFERENCE 1 (residues 1 to 396) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 396) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 396) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 396) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08633. On Apr 26, 2011 this sequence version replaced NP_012364.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..396 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..396 /product="Toh1p" /EC_number="3.2.1.39" /calculated_mol_wt="42827" Region 27..90 /region_name="YJL171C_Tos1_N" /note="Cell wall protein YJL171C/Tos1, N-terminal; pfam10290" /db_xref="CDD:463045" Region 107..336 /region_name="YJL171C_Tos1_C" /note="Cell wall protein YJL171C/Tos1, C-terminal; pfam10287" /db_xref="CDD:431198" CDS 1..396 /gene="TOH1" /locus_tag="YJL171C" /coded_by="NM_001181604.2:1..1191" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /note="GPI-anchored cell wall hypothetical protein; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853268" /db_xref="SGD:S000003707" ORIGIN 1 mlqsivlsvc mfmlhtvaas gpqsyqkldf tnvgftgsyv dvnkfkditn nesctcevgd 61 rvwfsgknap ladylsvhfr gplklkqfaf ytspgftvnn srsssdwnrl ayyessskta 121 dnvtflnhgg easpclgnal syassngtgs aseatvladg tlissdqeyi iysnvscpks 181 gydkgcgvyr sgipayygyg gttkmflfef emptetekns ssigyydlpa iwllndhiar 241 tsqyptnanc scwasgcgey difeamngte knhlystfht fqgiedlgtg iqsygyitrn 301 ttgtmkggvv fdssgnvvsf isdatpfngt vsadtvndll aaipenetys sqlmsisata 361 psttsksngv altkmqngvw yyilaiftaf tqvvli // LOCUS NP_012365 209 aa linear PLN 30-JUN-2025 DEFINITION Asg7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012365 VERSION NP_012365.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181603.1 REFERENCE 1 (residues 1 to 209) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 209) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 209) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 209) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08634. On Jan 23, 2006 this sequence version replaced NP_012365.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..209 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..209 /product="Asg7p" /calculated_mol_wt="24815" CDS 1..209 /gene="ASG7" /locus_tag="YJL170C" /coded_by="NM_001181603.1:1..630" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11073983]" /experiment="EXISTENCE:expression pattern:GO:0000747 conjugation with cellular fusion [PMID:10568744]" /note="Protein that regulates signaling from G protein beta subunit Ste4p; contributes to relocalization of Ste4p within the cell; specific to a-cells and induced by alpha-factor" /db_xref="GeneID:853269" /db_xref="SGD:S000003706" ORIGIN 1 mttlassieh ktkhlaapfe ndenpwmkky ccqcksckms vpvqpwlprf fvfgilcpvf 61 wlvnllawwf lqywqphele fhdlqedeyp gfyeyeaitk rtvipikeev lqeirvmqnf 121 sdsnseeyye skdgmpssfl nvnteqvede ndtlkkyrya flkkvahdvl eshdllrktf 181 rdwnlrsllg llidsiliif vvllckksr // LOCUS NP_012367 733 aa linear PLN 30-JUN-2025 DEFINITION histone methyltransferase SET2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012367 VERSION NP_012367.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181601.2 REFERENCE 1 (residues 1 to 733) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 733) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 733) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 733) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08635. On Apr 26, 2011 this sequence version replaced NP_012367.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..733 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..733 /product="histone methyltransferase SET2" /EC_number="2.1.1.359" /calculated_mol_wt="84331" Region 64..119 /region_name="AWS" /note="associated with SET domains; smart00570" /db_xref="CDD:197795" Region 119..260 /region_name="SET_SETD2" /note="SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; cd19172" /db_xref="CDD:380949" Site order(130..132,149,159,163,167,172..178,195..199,206..208, 223,234..238,240..244,246..250,259) /site_type="active" /db_xref="CDD:380949" Site order(130..132,172..175,195..199,236,246..250,259) /site_type="other" /note="SAM binding site" /db_xref="CDD:380949" Site order(149,159,163,174..178,206..208,223,234..238) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:380949" Site order(201,248,250,255) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:380949" Region 479..505 /region_name="WW_1" /note="WW domain; pfam18507" /db_xref="CDD:375933" Region 545..>626 /region_name="TolA" /note="Membrane protein TolA involved in colicin uptake [Cell wall/membrane/envelope biogenesis]; COG3064" /db_xref="CDD:442298" Region 627..703 /region_name="SRI" /note="SRI (Set2 Rpb1 interacting) domain; pfam08236" /db_xref="CDD:462404" CDS 1..733 /gene="SET2" /locus_tag="YJL168C" /gene_synonym="EZL1; KMT3" /coded_by="NM_001181601.2:1..2202" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:28483910]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006354 DNA-templated transcription elongation [PMID:12736296]" /experiment="EXISTENCE:direct assay:GO:0006355 regulation of DNA-templated transcription [PMID:11839797]" /experiment="EXISTENCE:direct assay:GO:0046975 histone H3K36 methyltransferase activity [PMID:11839797]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:35263330]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11839797]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:19417103]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:17150765]" /experiment="EXISTENCE:mutant phenotype:GO:0045128 negative regulation of reciprocal meiotic recombination [PMID:18515193]" /experiment="EXISTENCE:mutant phenotype:GO:0046975 histone H3K36 methyltransferase activity [PMID:11839797]" /experiment="EXISTENCE:mutant phenotype:GO:0060195 negative regulation of antisense RNA transcription [PMID:21248844]" /note="Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for their deacetylation within transcribed genes; involved in transcription coupled-nucleotide excision repair; associates with C-terminal domain (CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to cytosol in response to hypoxia" /db_xref="GeneID:853271" /db_xref="SGD:S000003704" ORIGIN 1 msknqsvsas edekeilnnn aeghkpqrlf dqepdlteea ltkfenlddc iyankrigtf 61 knndfmecdc yeefsdgvnh acdedsdcin rltliecvnd lcsscgndcq nqrfqkkqya 121 piaifktkhk gygvraeqdi eanqfiyeyk gevieemefr drlidydqrh fkhfyfmmlq 181 ngefidatik gslarfcnhs cspnayvnkw vvkdklrmgi faqrkilkge eitfdynvdr 241 ygaqaqkcyc eepncigflg gktqtdaasl lpqniadalg vtvsmekkwl klkklsgepi 301 iknenenini eflqslevqp idspvdvtki msvllqqdnk iiaskllkrl ftidddslrh 361 qaiklhgytc fskmlklfit eqpqvdgkgn eteeddikfi kgildfllel pkttrngies 421 sqidnvvktl pakfpflkpn cdellekwsk fetykritkk dinvaaskmi dlrrvrlppg 481 weiihengrp lyynaeqktk lhyppsgssk vfssrsntqv nspsssgipk tpgaldskkh 541 klsdeeyerk kqkrleyeri alerakqeel eslkqklkle nerksvledi iaeankqkel 601 qkeeakklve akeakrlkrk tvsqsqrleh nwnkffasfv pnlikknpqs kqfdhenikq 661 cakdivkilt tkelkkdssr appddltkgk rhkvkefins ymdkiilkkk qkkalalssa 721 strmssppps tss // LOCUS NP_012368 352 aa linear PLN 30-JUN-2025 DEFINITION bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012368 VERSION NP_012368.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181600.1 REFERENCE 1 (residues 1 to 352) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 352) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 352) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 352) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08636. Method: conceptual translation. FEATURES Location/Qualifiers source 1..352 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..352 /product="bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase" /EC_number="2.5.1.1" /EC_number="2.5.1.10" /calculated_mol_wt="40352" Region 38..304 /region_name="polyprenyl_synt" /note="Polyprenyl synthetase; pfam00348" /db_xref="CDD:459773" CDS 1..352 /gene="ERG20" /locus_tag="YJL167W" /gene_synonym="BOT3; FDS1; FPP1" /coded_by="NM_001181600.1:1..1059" /experiment="EXISTENCE:direct assay:GO:0004161 dimethylallyltranstransferase activity [PMID:2681213]" /experiment="EXISTENCE:direct assay:GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity [PMID:2681213]" /experiment="EXISTENCE:direct assay:GO:0004452 isopentenyl-diphosphate delta-isomerase activity [PMID:7908830]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19416104]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:19416104]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:7908830]" /experiment="EXISTENCE:direct assay:GO:0008299 isoprenoid biosynthetic process [PMID:2681213]" /experiment="EXISTENCE:direct assay:GO:0045337 farnesyl diphosphate biosynthetic process [PMID:2681213]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:1779710]" /note="Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis" /db_xref="GeneID:853272" /db_xref="SGD:S000003703" ORIGIN 1 masekeirre rflnvfpklv eelnasllay gmpkeacdwy ahslnyntpg gklnrglsvv 61 dtyailsnkt veqlgqeeye kvailgwcie llqayflvad dmmdksitrr gqpcwykvpe 121 vgeiaindaf mleaaiykll kshfrnekyy iditelfhev tfqtelgqlm dlitapedkv 181 dlskfslkkh sfivtfktay ysfylpvala myvagitdek dlkqardvli plgeyfqiqd 241 dyldcfgtpe qigkigtdiq dnkcswvink alelasaeqr ktldenygkk dsvaeakckk 301 ifndlkieql yheyeesiak dlkakisqvd esrgfkadvl taflnkvykr sk // LOCUS NP_012369 94 aa linear PLN 30-JUN-2025 DEFINITION ubiquinol--cytochrome-c reductase subunit 8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012369 VERSION NP_012369.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181599.1 REFERENCE 1 (residues 1 to 94) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 94) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 94) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 94) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08637. Method: conceptual translation. FEATURES Location/Qualifiers source 1..94 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..94 /product="ubiquinol--cytochrome-c reductase subunit 8" /calculated_mol_wt="10843" Region 12..89 /region_name="UcrQ" /note="UcrQ family; pfam02939" /db_xref="CDD:460757" CDS 1..94 /gene="QCR8" /locus_tag="YJL166W" /gene_synonym="COR5" /coded_by="NM_001181599.1:1..285" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:10873857]" /experiment="EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:8394810]" /experiment="EXISTENCE:mutant phenotype:GO:0008121 quinol-cytochrome-c reductase activity [PMID:8786239]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8394810]" /note="Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p" /db_xref="GeneID:853273" /db_xref="SGD:S000003702" ORIGIN 1 mgppsgktym gwwghmggpk qkgitsyavs pyaqkplqgi fhnavfnsfr rfksqflyvl 61 ipagiywyww kngneynefl yskagreele rvnv // LOCUS NP_012370 855 aa linear PLN 30-JUN-2025 DEFINITION protein kinase HAL5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012370 VERSION NP_012370.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181598.1 REFERENCE 1 (residues 1 to 855) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 855) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 855) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 855) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 855) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 855) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 855) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08638. Method: conceptual translation. FEATURES Location/Qualifiers source 1..855 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..855 /product="protein kinase HAL5" /EC_number="2.7.11.1" /calculated_mol_wt="95324" Region 509..837 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(509..512,515,517,544,546,604,620..623,688,692..693, 695,705..706) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270896" CDS 1..855 /gene="HAL5" /locus_tag="YJL165C" /coded_by="NM_001181598.1:1..2568" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:32191698]" /experiment="EXISTENCE:genetic interaction:GO:0008104 intracellular protein localization [PMID:21237705]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:10207057]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:32191698]" /note="Snf1p-related nutrient-responsive protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication" /db_xref="GeneID:853274" /db_xref="SGD:S000003701" ORIGIN 1 mgdeklsrht slkrarslse sikglfkpsg isgsnnaaap ssrpgqdqah shqtariits 61 nvsspsispv hspvlqaapk hhklgvpnia klslspsrep slnsenemfs qesfisekde 121 deanllered lqnkkeekar akhvrskeay vphhrytvgs deverqprer lknfpqnags 181 snpansnanh vldqennfsi damldydees klrrrnslgv rnhsnrtrsr knslstprsp 241 pmkngnggmn snatnnvgng tgnriymrgr nhsdsisass lpkfqeieck cildlghfkv 301 fengyhehsl rvlpiitnnk nvdsgdekda dasvnsgddg dndseanmhk qksvfslsgl 361 fkshkdgnqq qqqqqqqeen geqinlekaf siipsqrfik sqtlkksrts nlkngnndel 421 mkndgknipq ivnpnaavgv eelklinals ekirkglkse ntkgnngegr snsnkqedsd 481 dtegkagttn ddtshkpcsq kygksigvvg agaygvvkic arcktakdvl pystysngkk 541 lffavkelkp kpgdqidkfc trltsefiig hslshphfea namiagnvsr ttppkhvfna 601 pnilkildlm eysnsfvevm efcasgdlys lltrnnisne snngssrliq tvkegsgspl 661 hpleadcfmk qllngvqymh dhgiahcdlk penilfqpng llkicdfgts svfqtawekh 721 vhfqsgamgs epyvapeefi rdaeydprlv dcwscgivyc tmvmgqylwk iaipekdslf 781 ksflseikdd gqfylfeelr hvsselnrlr kialyrtfqv dptkritieq llqsswmrkt 841 kccvvyrhlh tkvsk // LOCUS NP_012371 397 aa linear PLN 30-JUN-2025 DEFINITION cAMP-dependent protein kinase catalytic subunit TPK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012371 VERSION NP_012371.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181597.2 REFERENCE 1 (residues 1 to 397) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 397) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 397) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 397) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08639. On Apr 26, 2011 this sequence version replaced NP_012371.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..397 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..397 /product="cAMP-dependent protein kinase catalytic subunit TPK1" /EC_number="2.7.11.11" /calculated_mol_wt="45945" Region 85..375 /region_name="STKc_PKA_like" /note="Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; cd05580" /db_xref="CDD:270732" Site order(93..99,101,114,116,148,164..167,171,210,212,214..215, 217,227..228,372) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270732" Site order(94..99,101,114,116,126,148,164..165,167,171,173,177, 210,212..215,217,227..228,231,242,244..247,274,278..280, 283..285,287,290,372,375) /site_type="active" /db_xref="CDD:270732" Site order(95,97..98,126..128,171,173,177,210,212..214,231, 242..247,274,278..280,283..285,287,290..291,375) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270732" Site order(97,127..128,130..131,171,173,177,212..214,231, 240..245,248,255..256,274,287..288,291..292,295,375) /site_type="other" /note="regulatory subunit interface [polypeptide binding]" /db_xref="CDD:270732" Site order(227..235,239..247) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270732" CDS 1..397 /gene="TPK1" /locus_tag="YJL164C" /gene_synonym="PKA1; SRA3" /coded_by="NM_001181597.2:1..1194" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:26403272]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004691 cAMP-dependent protein kinase activity [PMID:34244791|PMID:3036373]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10625697]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10625697]" /experiment="EXISTENCE:direct assay:GO:0005952 cAMP-dependent protein kinase complex [PMID:12024012]" /experiment="EXISTENCE:direct assay:GO:0018105 peptidyl-serine phosphorylation [PMID:34244791]" /experiment="EXISTENCE:genetic interaction:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0005952 cAMP-dependent protein kinase complex [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:34244791|PMID:33008596]" /experiment="EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly [PMID:21925385]" /experiment="EXISTENCE:genetic interaction:GO:0010737 protein kinase A signaling [PMID:20133652]" /experiment="EXISTENCE:mutant phenotype:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:34244791|PMID:33008596]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:34244791]" /experiment="EXISTENCE:mutant phenotype:GO:0007265 Ras protein signal transduction [PMID:2823100]" /experiment="EXISTENCE:mutant phenotype:GO:0016241 regulation of macroautophagy [PMID:15016820]" /experiment="EXISTENCE:mutant phenotype:GO:0018105 peptidyl-serine phosphorylation [PMID:34244791]" /experiment="EXISTENCE:physical interaction:GO:0005952 cAMP-dependent protein kinase complex [PMID:12024012]" /note="cAMP-dependent protein kinase catalytic subunit; role in nutrient-stimulated growth via Ras-cAMP signaling; inhibited by regulatory subunit Bcy1p in cAMPs absence; phosphorylates and inhibits Whi3p to promote G1/S phase passage; phosphorylates Nej1p to regulate nonhomologous end joining (NHEJ); impairs mitochondrial import of pre-Tom40p via phosphorylation under non-respiratory conditions; partially redundant with Tpk2p and Tpk3p; human homolog PRKACB regulates NHEJ via NHEJ1 phosphorylation" /db_xref="GeneID:853275" /db_xref="SGD:S000003700" ORIGIN 1 msteeqnggg qkslddrqge esqkgetser ettatesgne sksvekegge tqekpkqphv 61 tyyneeqykq fiaqarvtsg kyslqdfqil rtlgtgsfgr vhlirsrhng ryyamkvlkk 121 eivvrlkqve htnderlmls ivthpfiirm wgtfqdaqqi fmimdyiegg elfsllrksq 181 rfpnpvakfy aaevclaley lhskdiiyrd lkpenilldk nghikitdfg fakyvpdvty 241 tlcgtpdyia pevvstkpyn ksidwwsfgi liyemlagyt pfydsntmkt yekilnaelr 301 fppffnedvk dllsrlitrd lsqrlgnlqn gtedvknhpw fkevvwekll srnietpyep 361 piqqgqgdts qfdkypeedi nygvqgedpy adlfrdf // LOCUS NP_012372 555 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL163C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012372 VERSION NP_012372.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181596.1 REFERENCE 1 (residues 1 to 555) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 555) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 555) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 555) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08640. Method: conceptual translation. FEATURES Location/Qualifiers source 1..555 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..555 /product="uncharacterized protein" /calculated_mol_wt="61394" Region 139..545 /region_name="MFS" /note="Major Facilitator Superfamily; cl28910" /db_xref="CDD:475125" Site order(146,203..204,206..208,212,232,235..236,239,360, 363..364,367..369,372,404,408,468..469,473,477,493, 496..497,500..501,504) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:349949" CDS 1..555 /locus_tag="YJL163C" /coded_by="NM_001181596.1:1..1668" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /note="hypothetical protein" /db_xref="GeneID:853276" /db_xref="SGD:S000003699" ORIGIN 1 msnedettrl mssdemdyll etaginalee iisqndstgi nldtnetaqd ssydsirrsp 61 silsvaksve gehgrrkllc lyglvmiici aesismtati plvmdkvaeg isdenghyds 121 vavqtivssi ssstmmiaga isifmagkwg elsdrigrvr vfkymsgirv igllthvftl 181 sskmkyhkwa ivltacivps fgglfalvan gnsyvsdivk tehrmvtigi mmsciyatmg 241 vgpmfgsflv kwthgngfip iytsiafvil aliicetimv eprhetqmah sqstytkrre 301 klrsqsgsdd arnyqsvtyg kfqimrlmdl lapvkklwlk pdsagslvpr htvillivld 361 ilfvcgttsc mpalilfsty eykwhavelg yfisilgigr gvvllvvspt llytlkriyq 421 hlnhsidkid ifciqfsmiv itlslfvmir fgektptsmi ifallqalsa fcsptlqsgi 481 ikytskkhtg emfgamalvr scvmlvippi llklygstvs vnpslfmyip fstsivaill 541 tfflriyknp pldgp // LOCUS NP_012373 583 aa linear PLN 30-JUN-2025 DEFINITION Jjj2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012373 VERSION NP_012373.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181595.1 REFERENCE 1 (residues 1 to 583) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 583) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 583) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 583) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08641. On Jan 23, 2006 this sequence version replaced NP_012373.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..583 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..583 /product="Jjj2p" /calculated_mol_wt="67259" Region 13..124 /region_name="DnaJ" /note="DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; COG0484" /db_xref="CDD:440252" CDS 1..583 /gene="JJJ2" /locus_tag="YJL162C" /coded_by="NM_001181595.1:1..1752" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; contains a J-domain, which is a region with homology to the E. coli DnaJ protein" /db_xref="GeneID:853277" /db_xref="SGD:S000003698" ORIGIN 1 msqviepqld rttyysilgl tsnatssevh ksylklarll hpdktksdks eelfkavvha 61 hsiltdedqk lrydrdlkik glhtyqpkkn chifktkake sqgasptlgq seayhrqnkp 121 yeqqpygfgv gkkmtsssks kvpifksfnl ksyqrnhyys skkerkhgsp didslfhetn 181 gaskvrmtda gkmdtnsqfq eiweilgkna ythksysedp nsclgsalsd heeeeeagkq 241 qqqqqqqqqq qqhygmtsks sspdeekknn kepkresrvs peengeeetg hkqfklpkts 301 tfssgshdsn lqspfynhey rhyarskfec knqfrksvsp ikeipattsa negwnilrdi 361 ieklnisnvd drnkdllfrr deigdknhsd sidienlsik epkgmkrrkk ddisleelfq 421 slprekdyfm mdaindsles inlfkkpktt qsheqggtfa qaesnrakfk plleqcgitp 481 eildleipei pefdavadle tlklnvqlfn nqcnklketi hqvslqrlra dtqfsdmltq 541 kqsimvwkty lefdkslmdk lnilqerqmq vikifsercd gkv // LOCUS NP_012374 180 aa linear PLN 30-JUN-2025 DEFINITION Fmp33p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012374 VERSION NP_012374.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181594.1 REFERENCE 1 (residues 1 to 180) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 180) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 180) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 180) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08642. Method: conceptual translation. FEATURES Location/Qualifiers source 1..180 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..180 /product="Fmp33p" /calculated_mol_wt="20054" CDS 1..180 /gene="FMP33" /locus_tag="YJL161W" /coded_by="NM_001181594.1:1..543" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:14562095]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:853279" /db_xref="SGD:S000003697" ORIGIN 1 mlytrllrhn sqftkfsgts pnlgskplfs kgnlytsllv ttlygtglac lylesnslnk 61 skeqedphai aeddivnivh dapnrifkpa ldtyqekeld lqksdlhkvl hsltysdvsq 121 fsivwgfliq lsslignstl gkksilykgs vvsvlgfppl iymalklrmk qlekagvrfe // LOCUS NP_012375 287 aa linear PLN 30-JUN-2025 DEFINITION beta-1,3-glucan linked protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012375 VERSION NP_012375.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181593.1 REFERENCE 1 (residues 1 to 287) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 287) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 287) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 287) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08643. On Feb 23, 2004 this sequence version replaced NP_012375.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..287 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..287 /product="beta-1,3-glucan linked protein" /calculated_mol_wt="30084" CDS 1..287 /gene="PIR5" /locus_tag="YJL160C" /coded_by="NM_001181593.1:1..864" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; member of the PIR (Proteins with Internal Repeats) family of cell wall proteins; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, and mCherry fusion localizes to the vacuole; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis; YJL160C has a paralog, PIR1, that arose from the whole genome duplication" /db_xref="GeneID:853280" /db_xref="SGD:S000003696" ORIGIN 1 mhykkaflas llssialtay appepwatlt psskmdggtt eyrtsfglav ipftvteskv 61 krnvisqind gqvqvttqkl phpvsqigdg qiqvttqkvp pvvshivsqi gdgqlqitta 121 knvvtkstia vpsktvtata tstatavsqi hdgqvqvtis sassssvlsk skleptkkpn 181 nekvikvqac kssgtlaitl qggvlidssg rigsivanrq fqfdgpppqa gaiyaggwsi 241 tkhgtlaigd ndvfyqclsg tfynlydqsi ggqcnpvhlq tvglvdc // LOCUS NP_012376 413 aa linear PLN 30-JUN-2025 DEFINITION heat shock protein HSP150 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012376 VERSION NP_012376.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181592.1 REFERENCE 1 (residues 1 to 413) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 413) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 413) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 413) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08644. On Oct 10, 2006 this sequence version replaced NP_012376.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..413 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..413 /product="heat shock protein HSP150" /calculated_mol_wt="40928" CDS 1..413 /gene="HSP150" /locus_tag="YJL159W" /gene_synonym="CCW7; ORE1; PIR2" /coded_by="NM_001181592.1:1..1242" /experiment="EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:10209754]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:19129178]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:16278454]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10209754|PMID:9192695|PMID:15781460]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:21446055]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:21446055]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10407261]" /note="O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication" /db_xref="GeneID:853281" /db_xref="SGD:S000003695" ORIGIN 1 mqykktlvas alaattlaay apsepwstlt ptatysggvt dyastfgiav qpisttssas 61 saattasska kraasqigdg qvqaatttas vstkstaaav sqigdgqiqa ttkttaaavs 121 qigdgqiqat tkttsaktta aavsqisdgq iqattttlap kstaaavsqi gdgqvqattt 181 tlapkstaaa vsqigdgqvq attkttaaav sqigdgqvqa ttkttaaavs qigdgqvqat 241 tkttaaavsq igdgqvqatt kttaaavsqi tdgqvqattk ttqaasqvsd gqvqattats 301 asaaatstdp vdavscktsg tlemnlkggi ltdgkgrigs ivanrqfqfd gpppqagaiy 361 aagwsitpdg nlaigdndvf yqclsgtfyn lydehigsqc tpvhleaidl idc // LOCUS NP_012377 227 aa linear PLN 30-JUN-2025 DEFINITION Cis3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012377 VERSION NP_012377.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181591.1 REFERENCE 1 (residues 1 to 227) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 227) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 227) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 227) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08645. Method: conceptual translation. FEATURES Location/Qualifiers source 1..227 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..227 /product="Cis3p" /calculated_mol_wt="23110" CDS 1..227 /gene="CIS3" /locus_tag="YJL158C" /gene_synonym="CCW11; CCW5; PIR4; SCW8" /coded_by="NM_001181591.1:1..684" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:12702350|PMID:19129178]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10438739]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10438739|PMID:15781460]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10407261]" /note="Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family" /db_xref="GeneID:853282" /db_xref="SGD:S000003694" ORIGIN 1 mqfknvalaa svaalsatas aegytpgepw stltptgsis cgaaeytttf giavqaitss 61 kakrdvisqi gdgqvqatsa ataqatdsqa qatttatpts sekisssask tstnatsssc 121 atpslkdssc knsgtleltl kdgvltdakg rigsivanrq fqfdgpppqa gaiyaagwsi 181 tedgylalgd sdvfyqclsg nfynlydqnv aeqcsaihle avslvdc // LOCUS NP_012378 830 aa linear PLN 30-JUN-2025 DEFINITION cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012378 VERSION NP_012378.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181590.1 REFERENCE 1 (residues 1 to 830) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 830) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 830) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 830) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08646. Method: conceptual translation. FEATURES Location/Qualifiers source 1..830 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..830 /product="cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1" /calculated_mol_wt="94442" Region 202..251 /region_name="RING" /note="Ring finger; smart00184" /db_xref="CDD:214546" CDS 1..830 /gene="FAR1" /locus_tag="YJL157C" /coded_by="NM_001181590.1:1..2493" /experiment="EXISTENCE:direct assay:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:8066461]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9822386|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:9822386]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:14988725]" /experiment="EXISTENCE:direct assay:GO:0120171 Cdc24p-Far1p-Gbetagamma complex [PMID:10087263]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:7490290|PMID:10087263]" /experiment="EXISTENCE:mutant phenotype:GO:0000751 mitotic cell cycle G1 arrest in response to pheromone [PMID:2147873]" /experiment="EXISTENCE:mutant phenotype:GO:0043577 chemotropism [PMID:7490290|PMID:10087263]" /experiment="EXISTENCE:mutant phenotype:GO:0051457 maintenance of protein location in nucleus [PMID:10655592]" /experiment="EXISTENCE:physical interaction:GO:0120171 Cdc24p-Far1p-Gbetagamma complex [PMID:10087263]" /note="CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites" /db_xref="GeneID:853283" /db_xref="SGD:S000003693" ORIGIN 1 mktptrvsfe kkihtppsgd rdaersppkk flrglsgkvf rktpefkkqq mptfgyiees 61 qftpnlglmm skrgnipkpl nlskpisppp slkktagsva sgfsktgqls alqspvnits 121 snkynikatn lttsllresi sdsttmcdtl sdinltvmde dyridgdsyy eedsptfmis 181 lernikkcns qfspkryige kcliceesis stftgekvve stcshtshyn cylmlfetly 241 fqgkfpecki cgevskpkdk divpemvskl ltgagahddg pssnmqqqwi dlktarsftg 301 efpqftpqeq lirtadiscd gfrtprlsns nqfeavsyld spflnspfvn kmattdpfdl 361 sddekldcdd eidesaaevw fsktggehvm vsvkfqemrt sddlgvlqdv nhvdheelee 421 rekewkkkid qyietnvdkd sefgslilfd klmysddgeq wvdnnlvilf skflvlfdfe 481 emkilgkipr dqfyqvikfn edvllcslks tnipeiylrf nencekwllp kwkyclenss 541 letlplseiv stvkelshvn iigalgappd visaqshdsr lpwkrlhsdt plklivclnl 601 shadgelyrk rvlksvhqil dglntddllg ivvvgrdgsg vvgpfgtfig minknwdgwt 661 tfldnlevvn pnvfrdekqq ykvtlqtcer lastsayvdt ddhiatgyak qilvlngsdv 721 vdiehdqklk kafdqlsyhw ryeisqrrmt plnasikqfl eelhtkryld vtlrlpqatf 781 eqvylgdmaa geqktrlimd ehphssliei eyfdlvkqqr ihqtlevpnl // LOCUS NP_012379 699 aa linear PLN 30-JUN-2025 DEFINITION Ssy5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012379 VERSION NP_012379.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181589.1 REFERENCE 1 (residues 1 to 699) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 699) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 699) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 699) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08647. On Nov 27, 2009 this sequence version replaced NP_012379.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..699 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..699 /product="Ssy5p" /calculated_mol_wt="77396" Region 1..693 /region_name="Peptidase_S64" /note="Peptidase family S64; pfam08192" /db_xref="CDD:369740" CDS 1..699 /gene="SSY5" /locus_tag="YJL156C" /gene_synonym="RAA3" /coded_by="NM_001181589.1:1..2100" /experiment="EXISTENCE:direct assay:GO:0004252 serine-type endopeptidase activity [PMID:29661936|PMID:16778074]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11154269]" /experiment="EXISTENCE:direct assay:GO:0016485 protein processing [PMID:16778074]" /experiment="EXISTENCE:genetic interaction:GO:0043200 response to amino acid [PMID:11154269]" /experiment="EXISTENCE:mutant phenotype:GO:0004252 serine-type endopeptidase activity [PMID:16524914]" /experiment="EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:16524914]" /experiment="EXISTENCE:mutant phenotype:GO:0016540 protein autoprocessing [PMID:29661936]" /experiment="EXISTENCE:mutant phenotype:GO:0043200 response to amino acid [PMID:11154269]" /note="Serine protease of SPS plasma membrane amino acid sensor system; contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p; other members are Ssy1p and Ptr3p" /db_xref="GeneID:853285" /db_xref="SGD:S000003692" ORIGIN 1 mvrffglnkk kneekentdl padneqnaae tsssnvsgne eridpnshdt npenanndda 61 sttfgssiqs ssifsrgrmt ygtgasssma tsemrshssg hsgsknsknl qgfkdvgkpl 121 ravsflspvk eeesqdtqnt ldvssstsst latsenaren sftsrrsitl eyihkslsel 181 eenlvdimdd ihqdvisisk avieaieyfk eflpttrdri pyrislekss slrkinkivl 241 hfldnllvsd afsnsrsill rrfyfflkkl nlitdddlis esgvlpclsv fcigshcnlp 301 smdklgmild eltkmdssii sdqegafiap ilrgitpkss iltimfglpn lqhehyemik 361 vlyslfpdvh mycvkdyikk aasavgsips htaatidtia ptkfqfsppy avsenplelp 421 ismslstets akitgtlggy lfpqtgsdkk fsqfascsfa itcahvvlse kqdypnvmvp 481 snvlqtsykk vltkesdryp dgsvektafl eevqridqnl nwqksnkfgq vvwgeraivd 541 hrlsdfaiik vnssfkcqnt lgnglksfpd ptlrfqnlhv krkifkmkpg mkvfkigast 601 gytsgelnst klvywadgkl qssefvvasp tplfasagds gawiltkled rlglglvgml 661 hsydgeqrqf glftpigdil erlhavtkiq wdidpqldg // LOCUS NP_012380 452 aa linear PLN 30-JUN-2025 DEFINITION fructose-2,6-bisphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012380 VERSION NP_012380.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181588.1 REFERENCE 1 (residues 1 to 452) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 452) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 452) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 452) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08648. Method: conceptual translation. FEATURES Location/Qualifiers source 1..452 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..452 /product="fructose-2,6-bisphosphatase" /EC_number="3.1.3.46" /calculated_mol_wt="52464" Region 1..224 /region_name="6PF2K" /note="6-phosphofructo-2-kinase; pfam01591" /db_xref="CDD:396253" Region 227..411 /region_name="His_Phos_1" /note="Histidine phosphatase superfamily (branch 1); pfam00300" /db_xref="CDD:459751" CDS 1..452 /gene="FBP26" /locus_tag="YJL155C" /coded_by="NM_001181588.1:1..1359" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity [PMID:1322693]" /experiment="EXISTENCE:mutant phenotype:GO:0006006 glucose metabolic process [PMID:1322693]" /note="Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853286" /db_xref="SGD:S000003691" ORIGIN 1 mgystisndn dikvcvimvg lpargksfis qkiirylswl sikakcfnvg nyrrdvsgnv 61 pmdaeffnfe ntdnfklrel aaqnaikdiv nfftkedgsv avfdatnstr krrkwlkdic 121 eknniqpmfl eswsndheli innakdigst spdyenseph vaeadfleri rqyerfyepl 181 dpqkdkdmtf iklvniieev vinkirtyle srivfyvmni rpkpkyiwls rhgesiynve 241 kkiggdssls ergfqyakkl eqlvkesage inltvwtstl krtqqtanyl pykklqwkal 301 deldagvcdg mtyeeiekey pedfkardnd kyeyryrgge syrdvvirle pvimelerqe 361 nvliithqav lrciyayfmn vpqeespwms iplhtlikle praygtkvtk ikanipavst 421 ykekgtsqvg elsqsstklh qllndspled kf // LOCUS NP_012381 944 aa linear PLN 30-JUN-2025 DEFINITION retromer subunit VPS35 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012381 VERSION NP_012381.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181587.1 REFERENCE 1 (residues 1 to 944) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 944) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 944) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 944) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08649. Method: conceptual translation. FEATURES Location/Qualifiers source 1..944 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..944 /product="retromer subunit VPS35" /calculated_mol_wt="109012" Region 8..828 /region_name="Vps35" /note="Vacuolar protein sorting-associated protein 35; pfam03635" /db_xref="CDD:427414" CDS 1..944 /gene="VPS35" /locus_tag="YJL154C" /gene_synonym="ENV1; GRD9; VPT7" /coded_by="NM_001181587.1:1..2835" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22593205]" /experiment="EXISTENCE:mutant phenotype:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0140312 cargo adaptor activity [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0005768 endosome [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0030906 retromer, cargo-selective complex [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0140312 cargo adaptor activity [PMID:9700157]" /note="Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; overexpression of wild-type human VPS35 or Parkinson's-associated vps35-D686N or vps35-P299S variants complements Ni2+ resistance and Cd2+ sensitivity of yeast vps35 null mutant" /db_xref="GeneID:853287" /db_xref="SGD:S000003690" ORIGIN 1 mayadspena iavikqrtal mnrclsqhkl meslqhtsim ltelrnpnls pkkyyelyvi 61 ifdsltnlst ylienhpqnh hladlyelvq ytgnvvprly lmitvgtsyl tfneapkkei 121 lkdmiemcrg vqnpirglfl ryylsqrtke llpeddpsfn sqfimnnfie mnklwvrlqh 181 qgplreretr trerkelqil vgsqlvrlsq iiddnfqmyk qdilptileq viqcrdlvsq 241 eylldvicqv fadefhlktl dtllqttlhl npdvsinkiv ltlvdrlndy vtrqleddpn 301 atstnayldm dvfgtfwdyl tvlnherpdl slqqfiplve svivlslkwy pnnfdnlnkl 361 felvlqktkd ygqknisles ehlflvllsf qnsklqltss ttappnspvt skkhfifqli 421 sqcqayknil alqsislqkk vvneiidilm dreveemadn dsesklhppg hsaylviedk 481 lqvqrllsic epliisrsgp panvassdtn vdevffnrhd eeeswildpi qeklahlihw 541 imnttsrkqt mknkiqfsle aqleilllik ssfikgginv kytfpaiitn fwklmrkcrm 601 iqeyllkkrp dnktllshys nllkqmfkfv srcindifns cnnsctdlil klnlqcaila 661 dqlqlneisy dffsqaftif eeslsdsktq lqaliyiaqs lqktrslyke ayydslivrc 721 tlhgskllkk qdqcravylc shlwwateis nigeeegitd nfyrdgkrvl eclqrslrva 781 dsimdneqsc elmveilnrc lyyfihgdes ethisikyin glieliktnl kslklednsa 841 smitnsisdl hitgennvka ssnaddgsvi tdkesnvaig sdgtyiqlnt lngsstlirg 901 vvatasgskl lhqlkyipih hfrrtceyie sqrevddrfk viyv // LOCUS NP_012382 533 aa linear PLN 30-JUN-2025 DEFINITION inositol-3-phosphate synthase INO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012382 VERSION NP_012382.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181586.1 REFERENCE 1 (residues 1 to 533) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 533) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 533) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 533) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08650. On Oct 2, 2003 this sequence version replaced NP_012382.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..533 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..533 /product="inositol-3-phosphate synthase INO1" /EC_number="5.5.1.4" /calculated_mol_wt="59511" Region 66..515 /region_name="NAD_binding_5" /note="Myo-inositol-1-phosphate synthase; pfam07994" /db_xref="CDD:462335" CDS 1..533 /gene="INO1" /locus_tag="YJL153C" /gene_synonym="APR1" /coded_by="NM_001181586.1:1..1602" /experiment="EXISTENCE:direct assay:GO:0004512 inositol-3-phosphate synthase activity [PMID:7016881]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006021 inositol biosynthetic process [PMID:7016881]" /note="Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element" /db_xref="GeneID:853288" /db_xref="SGD:S000003689" ORIGIN 1 mtedniapit svkvvtdkct ykdnelltky syenavvtkt asgrfdvtpt vqdyvfkldl 61 kkpeklgiml iglggnngst lvasvlankh nvefqtkegv kqpnyfgsmt qcstlklgid 121 aegndvyapf nsllpmvspn dfvvsgwdin nadlyeamqr sqvleydlqq rlkakmslvk 181 plpsiyypdf iaanqderan ncinldekgn vttrgkwthl qrirrdiqnf keenaldkvi 241 vlwtantery vevspgvndt menllqsikn dheeiapsti faaasilegv pyingspqnt 301 fvpglvqlae hegtfiagdd lksgqtklks vlaqflvdag ikpvsiasyn hlgnndgynl 361 sapkqfrske iskssviddi iasndilynd klgkkvdhci vikymkpvgd skvamdeyys 421 elmlgghnri sihnvcedsl latpliidll vmtefctrvs ykkvdpvked agkfenfypv 481 ltflsywlka pltrpgfhpv nglnkqrtal enflrlligl psqnelrfee rll // LOCUS NP_012384 133 aa linear PLN 30-JUN-2025 DEFINITION Sna3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012384 VERSION NP_012384.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181584.1 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 133) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08651. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..133 /product="Sna3p" /calculated_mol_wt="15068" Region 21..70 /region_name="Pmp3" /note="Proteolipid membrane potential modulator; pfam01679" /db_xref="CDD:460290" CDS 1..133 /gene="SNA3" /locus_tag="YJL151C" /coded_by="NM_001181584.1:1..402" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:22761830|PMID:23708375]" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:12499386|PMID:17182850]" /experiment="EXISTENCE:direct assay:GO:0031625 ubiquitin protein ligase binding [PMID:17332499|PMID:17182849]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:19944104]" /experiment="EXISTENCE:mutant phenotype:GO:0031625 ubiquitin protein ligase binding [PMID:17182849|PMID:17332499]" /experiment="EXISTENCE:mutant phenotype:GO:0032509 endosome transport via multivesicular body sorting pathway [PMID:22212814]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:17332499|PMID:17182849]" /note="Protein involved in efficient MVB sorting of proteins to the vacuole; may function as an RSP5 adapter protein for MVB cargos; integral membrane protein localized to vacuolar intralumenal vesicles" /db_xref="GeneID:853290" /db_xref="SGD:S000003687" ORIGIN 1 mdrdhindhd hrmsysinkd dlllmvlavf ippvavwkrk gmfnrdtlln lllflllffp 61 aiihacyvvy etssersydl srrhatapav drdleahpae esqaqppayd eddeagadvp 121 lmdnkqqlss grt // LOCUS NP_012386 663 aa linear PLN 30-JUN-2025 DEFINITION SCF ubiquitin ligase complex subunit DAS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012386 VERSION NP_012386.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181582.1 REFERENCE 1 (residues 1 to 663) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 663) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 663) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 663) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08652. Method: conceptual translation. FEATURES Location/Qualifiers source 1..663 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..663 /product="SCF ubiquitin ligase complex subunit DAS1" /calculated_mol_wt="77236" Region 48..91 /region_name="F-box_ScMDM30-like" /note="F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; cd22143" /db_xref="CDD:438915" Site order(52,56,59..60,63..64,68,70..71,75..77,79) /site_type="other" /note="putative Skp1 binding site [polypeptide binding]" /db_xref="CDD:438915" CDS 1..663 /gene="DAS1" /locus_tag="YJL149W" /gene_synonym="DUH1" /coded_by="NM_001181582.1:1..1992" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994|PMID:11283612]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /note="Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C" /db_xref="GeneID:853292" /db_xref="SGD:S000003685" ORIGIN 1 mpfqdyfqkk kaafinrnnk snadasalrd indininfaa ksknyvfplt klpdelmqev 61 fshlpqpdrl qlclvnkrln kiatkllyrr iylndsnvvk sdfmhlainw tllnlpsslk 121 eeesrdianc klkklietlq nnihiteviq wirinwdlds tlqrsilsil cnqgkslqrl 181 envtdpacnd iisnghfsrs nvssfdmapp nslpemvvpe nyipnltkyl sqrissrlsh 241 mtlfidplkl fnylypldik lqiidlklhw rrefynndyf vkkirpgnpl tklsevfdkr 301 tlkiltiisw ndtllkrete mlkdfkefen ledlslisik qdvhilvdlf ssltnlkrlk 361 mdfleeyvpe ptnphiflsi llacsklqfi dlrydglipq iiniqenkfq lnqqcnctnc 421 qivfsdilkg kifmfpedyy ihdlqdiaak difkmmkyls llpyskacda ypsvrtqpmn 481 ltnfvtkmnr nlleyrnsks qlvpkivnnp hqhstvtsts tahmsepemi iiddddddde 541 inaaippssd dtaatistdl elphesltkr diimcyhali hhfksiyvtf lksfphlrfl 601 mlndiptivm eennerifep vfyhydyksn lygwskesnk nlendsnnnn nnsdtiaria 661 tvm // LOCUS NP_012387 233 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase I subunit RPA34 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012387 VERSION NP_012387.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181581.1 REFERENCE 1 (residues 1 to 233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 233) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08653. Method: conceptual translation. FEATURES Location/Qualifiers source 1..233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..233 /product="DNA-directed RNA polymerase I subunit RPA34" /calculated_mol_wt="26744" Region 52..208 /region_name="RNA_polI_A34" /note="DNA-directed RNA polymerase I subunit RPA34.5; pfam08208" /db_xref="CDD:462395" CDS 1..233 /gene="RPA34" /locus_tag="YJL148W" /gene_synonym="CST21" /coded_by="NM_001181581.1:1..702" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969|PMID:9121426]" /experiment="EXISTENCE:direct assay:GO:0006362 transcription elongation by RNA polymerase I [PMID:18160037]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:9121426]" /experiment="EXISTENCE:mutant phenotype:GO:0005736 RNA polymerase I complex [PMID:9121426]" /note="RNA polymerase I subunit A34.5; essential for nucleolar assembly and for high polymerase loading rate; nucleolar localization depends on Rpa49p" /db_xref="GeneID:853293" /db_xref="SGD:S000003684" ORIGIN 1 msklskdyvs dsdsddevis nefsipdgfk kckhlknfpl ngdnkkkakq qqvwlikfps 61 nvdisklksl pvdfessttm tidkhdykim ddtdiesslt qdnlsnmtll vpseskeslk 121 iastakdnap lqfdkvfsvs etakipaidy skvrvprkdv pkveglkleh fatgydaedf 181 hvaeevkenk kepkkrshhd deeessekkk kkkekrekre kkdkkdkkkk hrd // LOCUS NP_012388 382 aa linear PLN 30-JUN-2025 DEFINITION Smt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012388 VERSION NP_012388.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181580.1 REFERENCE 1 (residues 1 to 382) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 382) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 382) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 382) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08654. Method: conceptual translation. FEATURES Location/Qualifiers source 1..382 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..382 /product="Smt1p" /calculated_mol_wt="44732" CDS 1..382 /gene="SMT1" /locus_tag="YJL147C" /gene_synonym="MRX5" /coded_by="NM_001181580.1:1..1149" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Translational repressor of the mitochondrial ATP6/8 mRNA; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage" /db_xref="GeneID:853294" /db_xref="SGD:S000003683" ORIGIN 1 mrrtfsqlat rllkskddel kstlkyltkg pvkllgplfe ssevneqgsl lnrsrtkenn 61 lqnhhienil rilnsnlpev eskkqkvavh ydvlfshlns ivtqatdnks ssskelqgss 121 sedlydrlll lqyvgkltnv rqiteillsk kfnkfdkvwe hralfdeyqr vvisillyyr 181 thdvqirkdy eprwlsdysd lpfplrrllw rcltsnvsed nirqniihyi kllganwrnn 241 dliliyqsly ekshilpdlt vlnhnkddgf sftqnqillv rilraiskcv eeepklvkkw 301 lidivklsiq skimlespkk pstpimdqyk firsldisir sihrtcqdkl ifedlqvnlg 361 svlkmineee helkthlpln li // LOCUS NP_012389 469 aa linear PLN 30-JUN-2025 DEFINITION Ids2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012389 VERSION NP_012389.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181579.1 REFERENCE 1 (residues 1 to 469) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 469) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 469) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 469) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08655. Method: conceptual translation. FEATURES Location/Qualifiers source 1..469 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..469 /product="Ids2p" /calculated_mol_wt="53086" Region 185..>308 /region_name="Glyco_tranf_GTA_type" /note="Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; cl11394" /db_xref="CDD:472172" Site order(190,192,221,294,296) /site_type="active" /db_xref="CDD:133018" CDS 1..469 /gene="IDS2" /locus_tag="YJL146W" /coded_by="NM_001181579.1:1..1410" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:30516470]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:30516470]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:7565676]" /note="Protein involved in modulation of Ime2p activity during meiosis; appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation" /db_xref="GeneID:853295" /db_xref="SGD:S000003682" ORIGIN 1 mdnqqesise ditgdlaaav rkswsesqdn plllnfnnsp igtptdrysp epatmmegna 61 mnlsslargs tqqqqrlygs sqtreksdqq qqdyqlfkhh yslgqetres vsdilndltl 121 gspepseras pirqpsvdvp plttrrssiq dvqwirhlln prssfsgass neptnspgdf 181 lnqsrawiti lhdssaeslq avivlaeslk nvnsqynlwv lhssevnafq laqvgiktli 241 ideyinlfmn fgtgsgfsas sqstetkgel nfkwcklflf fslidrfeli cylsptclvl 301 qnidellest evsdeidnet cvllsnkvny inedlvsvnq dqssaenydd dpqiiilkpn 361 ravamcikey ftiygndfeg eskrsmfhqm ndlqimkalf gdkwsyidsv gycavpiasv 421 panrlnykii efkilkpwer qnyiaagqhr esimnkwldl wrdflnqan // LOCUS NP_012390 294 aa linear PLN 30-JUN-2025 DEFINITION Sfh5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012390 VERSION NP_012390.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181578.1 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 294) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08656. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..294 /product="Sfh5p" /calculated_mol_wt="34257" Region 101..263 /region_name="SEC14" /note="Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); smart00516" /db_xref="CDD:214706" CDS 1..294 /gene="SFH5" /locus_tag="YJL145W" /coded_by="NM_001181578.1:1..885" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12869188|PMID:19477927]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19477927]" /experiment="EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0020037 heme binding [PMID:32780017]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:16262726]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762|PMID:12869188]" /experiment="EXISTENCE:genetic interaction:GO:0017157 regulation of exocytosis [PMID:19477927]" /experiment="EXISTENCE:genetic interaction:GO:0043001 Golgi to plasma membrane protein transport [PMID:10848624]" /experiment="EXISTENCE:genetic interaction:GO:0046488 phosphatidylinositol metabolic process [PMID:16262726]" /experiment="EXISTENCE:genetic interaction:GO:2000114 regulation of establishment of cell polarity [PMID:19477927]" /note="Unusual phosphatidylinositol transfer protein (PITP) that binds heme; similar to Sec14p; founding member of conserved class of fungal hemoproteins; exhibits PI- but not PC-transfer activity; localizes to peripheral endoplasmic reticulum, cytosol, and microsomes; partially relocalizes to plasma membrane upon DNA replication stress" /db_xref="GeneID:853296" /db_xref="SGD:S000003681" ORIGIN 1 mkfdndsekq vfdklkkaip giikekcagy delygyklnp egltqeevdk yydekiadrl 61 tyklckayqf eystivqnli dilnwrrefn plscaykevh ntelqnvgil tfdangdank 121 kavtwnlygq lvkkkelfqn vdkfvryrig lmekglslld ftssdnnymt qvhdykgvsv 181 wrmdsdiknc sktvigifqk yypellyaky fvnvptvfgw vydlikkfvd ettrkkfvvl 241 tdgsklgqyl kdcpyegygg kdkknnltkq nvtnvhptey glyilqkqii edve // LOCUS NP_012391 104 aa linear PLN 30-JUN-2025 DEFINITION Roq1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012391 VERSION NP_012391.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181577.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 104) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08657. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..104 /product="Roq1p" /calculated_mol_wt="11528" CDS 1..104 /gene="ROQ1" /locus_tag="YJL144W" /coded_by="NM_001181577.1:1..315" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:0042631 cellular response to water deprivation [PMID:21420397]" /experiment="EXISTENCE:mutant phenotype:GO:0055106 ubiquitin-protein transferase regulator activity [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:0120174 stress-induced homeostatically regulated protein degradation pathway [PMID:29861160]" /experiment="EXISTENCE:physical interaction:GO:0033554 cellular response to stress [PMID:29861160]" /experiment="EXISTENCE:physical interaction:GO:0055106 ubiquitin-protein transferase regulator activity [PMID:29861160]" /note="Ub-ligase substrate-specificity factor; proteolytically-cleaved form acts as a pseudosubstrate, binding and altering the substrate specificity of Ubr1p towards misfolded and native ER membrane and cytosolic proteins, as part of the stress-induced homeostatically regulated protein degradation (SHRED) pathway; hydrophilin essential during desiccation-rehydration; induced by osmotic stress, starvation and during stationary phase; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853297" /db_xref="SGD:S000003680" ORIGIN 1 mlrretstiy rthkksnssi lrsqrdqtrv dslveespmg dfginnqptq pgviyyfvel 61 tnlgiqents snnnnnnnhg ddengsrygh gsslggdvhs rrcs // LOCUS NP_012392 158 aa linear PLN 30-JUN-2025 DEFINITION protein transporter TIM17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012392 VERSION NP_012392.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181576.1 REFERENCE 1 (residues 1 to 158) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 158) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 158) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 158) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08658. Method: conceptual translation. FEATURES Location/Qualifiers source 1..158 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..158 /product="protein transporter TIM17" /calculated_mol_wt="16453" Region 2..158 /region_name="3a0801so1tim17" /note="mitochondrial import inner membrane translocase subunit tim17; TIGR00980" /db_xref="CDD:130053" CDS 1..158 /gene="TIM17" /locus_tag="YJL143W" /gene_synonym="MIM17; MPI2; SMS1" /coded_by="NM_001181576.1:1..477" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:15618217]" /experiment="EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:18826960]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:15618217|PMID:11344168]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:7600576|PMID:15618217|PMID:11344168|PMID:7919535]" /experiment="EXISTENCE:physical interaction:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:7600576]" /note="Essential core component of the TIM23 protein translocase complex; forms the protein translocation path with Mgr2p, while Tim23p contributes to the architecture of the import channel; may link the import motor to the core translocase of the inner mitochondrial membrane (TIM23 complex)" /db_xref="GeneID:853298" /db_xref="SGD:S000003679" ORIGIN 1 msadhsrdpc pivilndfgg afamgaiggv vwhgikgfrn splgergsga msaikarapv 61 lggnfgvwgg lfstfdcavk avrkredpwn aiiagfftgg alavrggwrh trnssitcac 121 llgviegvgl mfqryaawqa kpmapplpea pssqplqa // LOCUS NP_001381964 130 aa linear PLN 30-JUN-2025 DEFINITION Irc9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381964 VERSION NP_001381964.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395034.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 130) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54805. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..130 /product="Irc9p" /calculated_mol_wt="14713" CDS 1..130 /gene="IRC9" /locus_tag="YJL142C" /coded_by="NM_001395034.1:1..393" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="hypothetical protein; partially overlaps verified gene YAK1/YJL141C but does not share all phenotypes; null mutant displays increased levels of spontaneous Rad52p foci, increased sporulation efficiency, and small defect in vacuolar fragmentation" /db_xref="GeneID:853299" /db_xref="SGD:S000003678" ORIGIN 1 mtmqkaskvn mevrttlvtm qattmsiila lplvvliast lvlsvkgrri hlatspiill 61 llilfkkgqq arsinftlsk nkslfcltfl nypfhfitaw chndilnkye fclfliflir 121 ivitinkvtl // LOCUS NP_012394 807 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase YAK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012394 VERSION NP_012394.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181574.1 REFERENCE 1 (residues 1 to 807) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 807) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 807) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 807) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08659. Method: conceptual translation. FEATURES Location/Qualifiers source 1..807 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..807 /product="serine/threonine protein kinase YAK1" /EC_number="2.7.12.1" /calculated_mol_wt="91114" Region 369..704 /region_name="PKc_YAK1" /note="Catalytic domain of the Dual-specificity protein kinase, YAK1; cd14212" /db_xref="CDD:271114" Site order(375..379,383,396,398,412,433,449..452,455,457..458, 496,498,500..501,503,516,519,528,530..533,535,572) /site_type="active" /db_xref="CDD:271114" Site order(375..379,383,396,398,433,449..452,455,496,498, 500..501,503,516) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271114" Site order(412,457,496,498,519,528,530..533,535,572) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271114" Site 515..535 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271114" CDS 1..807 /gene="YAK1" /locus_tag="YJL141C" /coded_by="NM_001181574.1:1..2424" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:21255108]" /experiment="EXISTENCE:direct assay:GO:0004713 protein tyrosine kinase activity [PMID:21255108]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11358866|PMID:21255108]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11358866|PMID:21255108]" /experiment="EXISTENCE:genetic interaction:GO:0141156 cAMP/PKA signal transduction [PMID:8065298]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:21255108]" /experiment="EXISTENCE:mutant phenotype:GO:0004713 protein tyrosine kinase activity [PMID:21255108]" /note="Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose" /db_xref="GeneID:853300" /db_xref="SGD:S000003677" ORIGIN 1 mnssnnndss ssnsnmnnsl sptlvthsda smgsgraspd nshmgrgiwn psyvnqgsqr 61 spqqqhqnhh qqqqqqqqqq qqnsqfcfvn pwneekvtns qqnlvyppqy ddlnsnesld 121 ayrrrksslv vpparapapn pfqydsypay tssntslagn ssgqypsgyq qqqqqvyqqg 181 aihpsqfgsr fvpslydrqd fqrrqslaat nyssnfssln sntnqgtnsi pvmspyrrls 241 ayppstsppl qppfkqlrrd evqgqklsip qmqlcnsknd lqpvlnatpk frraslnskt 301 isplvsvtks littyslcsp eftyqtsknp krvltkpseg kcnngfdnin sdyilyvndv 361 lgveqnrkyl vldilgqgtf gqvvkcqnll tkeilavkvv ksrteyltqs iteakilell 421 nqkidptnkh hflrmydsfv hknhlclvfe llsnnlyell kqnkfhglsi qlirtfttqi 481 ldslcvlkes klihcdlkpe nillcapdkp elkiidfgss ceeartvyty iqsrfyrape 541 iilgipysts idmwslgciv aelflgipif pgaseynqlt riidtlgypp swmidmgkns 601 gkfmkklape esssstqkhr mktieefcre ynivekpskq yfkwrklpdi irnyrypksi 661 qnsqelidqe mqnreclihf lggvlnlnpl erwtpqqaml hpfitkqeft gewfppgssl 721 pgpsekhdda kgqqseygsa ndssnnaghn yvynpssatg gadsvdigai skrkentsgd 781 isnnfavths vqegptsafn klhivee // LOCUS NP_012395 221 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase II subunit RPB4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012395 VERSION NP_012395.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181573.1 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 221) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08660. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..221 /product="DNA-directed RNA polymerase II subunit RPB4" /calculated_mol_wt="25283" Region 15..221 /region_name="RPB4" /note="RNA polymerase II, fourth largest subunit [Transcription]; COG5250" /db_xref="CDD:227575" CDS 1..221 /gene="RPB4" /locus_tag="YJL140W" /gene_synonym="CTF15" /coded_by="NM_001181573.1:1..666" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:16357218]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:11087726]" /experiment="EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:11087726]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12857861]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:2186966|PMID:1331084|PMID:2183013]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12857861]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:11087726]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:16357218]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:11577101]" /experiment="EXISTENCE:mutant phenotype:GO:0045948 positive regulation of translational initiation [PMID:21074047]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:21074047]" /note="RNA polymerase II subunit B32; forms dissociable heterodimer with Rpb7p; Rpb4/7 dissociates from RNAPII as Ser2 CTD phosphorylation increases; Rpb4/7 regulates cellular lifespan via mRNA decay process; involved in recruitment of 3'-end processing factors to transcribing RNAPII complex, export of mRNA to cytoplasm under stress conditions; also involved in translation initiation" /db_xref="GeneID:853301" /db_xref="SGD:S000003676" ORIGIN 1 mnvststfqt rrrrlkkvee eenaatlqlg qefqlkqinh qgeeeelial nlsearlvik 61 ealverrraf krsqkkhkkk hlkhenande ttavededdd ldeddvnadd ddfmhsetre 121 kelesidvll eqttggnnkd lkntmqyltn fsrfrdqetv gaviqllkst glhpfevaql 181 gslacdtade aktlipslnn kisddeleri lkelsnletl y // LOCUS NP_012396 428 aa linear PLN 30-JUN-2025 DEFINITION mannosyltransferase YUR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012396 VERSION NP_012396.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181572.1 REFERENCE 1 (residues 1 to 428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 428) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08661. Method: conceptual translation. FEATURES Location/Qualifiers source 1..428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..428 /product="mannosyltransferase YUR1" /calculated_mol_wt="50705" Region 7..424 /region_name="KTR1" /note="Mannosyltransferase [Carbohydrate transport and metabolism]; COG5020" /db_xref="CDD:227353" CDS 1..428 /gene="YUR1" /locus_tag="YJL139C" /coded_by="NM_001181572.1:1..1287" /experiment="EXISTENCE:direct assay:GO:0000030 mannosyltransferase activity [PMID:8631921]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8631921]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:8631921]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:8631921]" /note="Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication" /db_xref="GeneID:853302" /db_xref="SGD:S000003675" ORIGIN 1 makggslyiv giflpiwtfm iyifgkelfl irkyqkidst ytalsqrvke qydtsrrrny 61 fpkvklsrns yddytlnytr qndsdsfhlr enatilmlvr nselegalds mrsledrfnn 121 kyhydwtfln dvpfdqdfie attsmasgkt qyalippedw nrpqwindtl feerlrvmed 181 egvlyggsks yrnmcrfnsg fffrqsildn ydyyfrvepn vkyycdfpyd pfrvmrlkgk 241 kygfvislye yeetiptlwd aveeylvase etilrkedsa yafltdsglv gkhypvvean 301 sdynlchfws nfeigdlnff rsdeykhffe tldakggfyy erwgdapvhs igvslllrpd 361 eiihfdelgy fhspfgtcpa syavrldqrc rcksddesvi ditphsclmr wwkngsgkyf 421 lkeeqdei // LOCUS NP_012397 395 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF4A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012397 VERSION NP_012397.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181571.1 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 395) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08662. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..395 /product="translation initiation factor eIF4A" /EC_number="3.6.4.13" /calculated_mol_wt="44566" Region 10..394 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Site order(24,42,44,49,68..74) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350804" Site order(25,35,38,43) /site_type="other" /note="eIF4G interface [polypeptide binding]" /db_xref="CDD:350804" CDS 1..395 /gene="TIF2" /locus_tag="YJL138C" /coded_by="NM_001181571.1:1..1188" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:1502180]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:1502180]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:1502180]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:24471916]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:1901195 positive regulation of formation of translation preinitiation complex [PMID:30281017|PMID:29192585]" /experiment="EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:1502180]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:1502180]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:1502180]" /experiment="EXISTENCE:mutant phenotype:GO:0016281 eukaryotic translation initiation factor 4F complex [PMID:2648398|PMID:10409745]" /note="Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853303" /db_xref="SGD:S000003674" ORIGIN 1 msegitdiee sqiqtnydkv vykfddmeld enllrgvfgy gfeepsaiqq raimpiiegh 61 dvlaqaqsgt gktgtfsiaa lqridtsvka pqalmlaptr elalqiqkvv malafhmdik 121 vhaciggtsf vedaeglrda qivvgtpgrv fdniqrrrfr tdkikmfild eademlssgf 181 keqiyqiftl lppttqvvll satmpndvle vttkfmrnpv rilvkkdelt legikqfyvn 241 veeeeykyec ltdlydsisv tqavifcntr rkveelttkl rndkftvsai ysdlpqqerd 301 timkefrsgs srilistdll argidvqqvs lvinydlpan kenyihrigr ggrfgrkgva 361 infvtnedvg amrelekfys tqieelpsdi atlln // LOCUS NP_012398 380 aa linear PLN 30-JUN-2025 DEFINITION glycogenin glucosyltransferase GLG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012398 VERSION NP_012398.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181570.1 REFERENCE 1 (residues 1 to 380) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 380) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 380) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 380) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08663. Method: conceptual translation. FEATURES Location/Qualifiers source 1..380 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..380 /product="glycogenin glucosyltransferase GLG2" /EC_number="2.4.1.186" /calculated_mol_wt="44415" Region 5..279 /region_name="GT8_Glycogenin" /note="Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; cd02537" /db_xref="CDD:133018" Site order(100..101,104,118,120..122,150,158..160,188..189, 227..228,249,251..252,255) /site_type="active" /note="substrate binding site [active]" /db_xref="CDD:133018" Site order(120,122,249) /site_type="active" /note="Manganese binding site [active]" /db_xref="CDD:133018" Site order(149..150,189,218,220..221,225,229) /site_type="active" /note="dimer interface [active]" /db_xref="CDD:133018" CDS 1..380 /gene="GLG2" /locus_tag="YJL137C" /coded_by="NM_001181570.1:1..1143" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0005978 glycogen biosynthetic process [PMID:8524228]" /experiment="EXISTENCE:genetic interaction:GO:0008466 glycogenin glucosyltransferase activity [PMID:8524228]" /note="Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication" /db_xref="GeneID:853304" /db_xref="SGD:S000003673" ORIGIN 1 makkvaictl lysrdylpga ltlayqlqkl lkhavvedei tlclliekkl fgdefkpqei 61 alirslfkei iiieplkdqe ksieknkanl ellkrpelsh tllkarlwel vqfdqvlfld 121 adtlplnkef feilrlypeq trfqiaavpd igwpdmfntg vlllipdldm atslqdflik 181 tvsidgadqg ifnqffnpic nyskevlhkv splmewirlp ftynvtmpny gyqsspamnf 241 fqqhirlihf igtfkpwsrn ttdyddhyyq lwrstqrely sechlsnyft hlqlgniete 301 tnfyheppcl qdllnhgkre nqkhvdldit svdrnasqks taekhdiekp tskpqsafkf 361 dwestdyldr vqrafpkpdt // LOCUS NP_878101 27 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL136W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878101 VERSION NP_878101.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184637.1 REFERENCE 1 (residues 1 to 27) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 27) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 27) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 27) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 27) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 27) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 27) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08664. Method: conceptual translation. FEATURES Location/Qualifiers source 1..27 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..27 /product="uncharacterized protein" /calculated_mol_wt="3013" CDS 1..27 /locus_tag="YJL136W-A" /coded_by="NM_001184637.1:1..84" /note="hypothetical protein; identified by SAGE" /db_xref="GeneID:1466464" /db_xref="SGD:S000028806" ORIGIN 1 mtrciskkml levdalsliy sphlyms // LOCUS NP_012399 87 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS21 RPS21B [Saccharomyces cerevisiae S288C]. ACCESSION NP_012399 VERSION NP_012399.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181569.1 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 87) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08665. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..87 /product="40S ribosomal protein eS21 RPS21B" /calculated_mol_wt="9629" Region 1..80 /region_name="Ribosomal_S21e" /note="Ribosomal protein S21e; pfam01249" /db_xref="CDD:460133" CDS 1..87 /gene="RPS21B" /locus_tag="YJL136C" /coded_by="NM_001181569.1:1..264" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /experiment="EXISTENCE:mutant phenotype:GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication" /db_xref="GeneID:853305" /db_xref="SGD:S000003672" ORIGIN 1 mendkgqlve lyvprkcsat nriikaddha svqinvakvd eegraipgey ityalsgyvr 61 srgesddsln rlaqndgllk nvwsysr // LOCUS NP_012401 409 aa linear PLN 30-JUN-2025 DEFINITION sphinganine kinase LCB3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012401 VERSION NP_012401.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181567.1 REFERENCE 1 (residues 1 to 409) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 409) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 409) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 409) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08666. Method: conceptual translation. FEATURES Location/Qualifiers source 1..409 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..409 /product="sphinganine kinase LCB3" /calculated_mol_wt="47241" Region 77..230 /region_name="PAP2_SPPase1" /note="PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second...; cd03388" /db_xref="CDD:239482" Site order(128,135,158..160,204,210,214) /site_type="active" /db_xref="CDD:239482" CDS 1..409 /gene="LCB3" /locus_tag="YJL134W" /gene_synonym="LBP1; YSR2" /coded_by="NM_001181567.1:1..1230" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10477278|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042392 sphingosine-1-phosphate phosphatase activity [PMID:9353337]" /experiment="EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:11278643]" /note="Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication" /db_xref="GeneID:853307" /db_xref="SGD:S000003670" ORIGIN 1 mvdglntsni rkrartlsnp ndfqepnyll dpgnhpsdhf rtrmskfrfn irekllvftn 61 nqsftlsrwq kkyrsafndl yftytslmgs htfyvlclpm pvwfgyfett kdmvyilgys 121 iylsgffkdy wclprprapp lhritlseyt tkeygapssh tanatgvsll flyniwrmqe 181 ssvmvqllls cvvlfyymtl vfgriycgmh gildlvsggl igivcfivrm yfkyrfpglr 241 ieehwwfplf svgwgllllf khvkpvdecp cfqdsvafmg vvsgieccdw lgkvfgvtlv 301 ynlepncgwr ltlarllvgl pcvviwkyvi skpmiytlli kvfhlkddrn vaarkrleat 361 hkegaskyec plyigepkid ilgrfiiyag vpftvvmcsp vlfsllnia // LOCUS NP_878102 74 aa linear PLN 30-JUN-2025 DEFINITION Dpi8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878102 VERSION NP_878102.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184636.1 REFERENCE 1 (residues 1 to 74) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 74) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 74) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 74) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08667. Method: conceptual translation. FEATURES Location/Qualifiers source 1..74 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..74 /product="Dpi8p" /calculated_mol_wt="7610" CDS 1..74 /gene="DPI8" /locus_tag="YJL133C-A" /coded_by="NM_001184636.1:1..225" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /note="Putative mitochondrial hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:1466465" /db_xref="SGD:S000028805" ORIGIN 1 miaqstrlaa avsssaasag vsriaasama stifkrspgn sfnsfkeyre naktygplsa 61 slatrrhlah apkl // LOCUS NP_012402 314 aa linear PLN 30-JUN-2025 DEFINITION Fe(2+) transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_012402 VERSION NP_012402.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181566.1 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 314) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08668. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..314 /product="Fe(2+) transporter" /calculated_mol_wt="34371" Region 34..251 /region_name="PTZ00168" /note="mitochondrial carrier protein; Provisional" /db_xref="CDD:185494" Region 215..314 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..314 /gene="MRS3" /locus_tag="YJL133W" /coded_by="NM_001181566.1:1..945" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:1703236]" /experiment="EXISTENCE:direct assay:GO:0048250 iron import into the mitochondrion [PMID:12902335]" /experiment="EXISTENCE:mutant phenotype:GO:0005381 iron ion transmembrane transporter activity [PMID:12902335]" /note="Iron transporter, mediates Fe2+ transport across inner mito membrane; mitochondrial carrier family member; active under low-iron conditions; may transport other cations; MRS3 has a paralog, MRS4, that arose from the whole genome duplication" /db_xref="GeneID:853308" /db_xref="SGD:S000003669" ORIGIN 1 mvensssnns trpipaipmd lpdyealpth aplyhqliag afagimehsv mfpidalktr 61 iqsanaksls aknmlsqish istsegtlal wkgvqsvilg agpahavyfg tyefckknli 121 dssdtqthhp fktaisgaca ttasdalmnp fdtikqriql ntsasvwqtt kqiyqsegla 181 afyysypttl vmnipfaafn fviyesstkf lnpsneynpl ihclcgsisg stcaaittpl 241 dciktvlqir gsqtvsleim rkadtfskaa saiyqvygwk gfwrgwkpri vanmpatais 301 wtayecakhf lmty // LOCUS NP_012403 750 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL132W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012403 VERSION NP_012403.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181565.1 REFERENCE 1 (residues 1 to 750) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 750) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 750) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 750) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08669. Method: conceptual translation. FEATURES Location/Qualifiers source 1..750 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..750 /product="uncharacterized protein" /calculated_mol_wt="84336" Region 35..234 /region_name="Zn_dep_PLPC" /note="Zinc dependent phospholipase C; pfam00882" /db_xref="CDD:425927" Region 334..>374 /region_name="Int_alpha" /note="Integrin alpha (beta-propellor repeats); smart00191" /db_xref="CDD:214549" CDS 1..750 /locus_tag="YJL132W" /coded_by="NM_001181565.1:1..2253" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11935221]" /note="hypothetical protein; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene" /db_xref="GeneID:853309" /db_xref="SGD:S000003668" ORIGIN 1 msiisswllv siiclttsiv tklqaagvtt hlfyltrgap lslkenyypw lkagsffpda 61 lyscapsnkd wsdfaefthw pnflmiavsy wqqkygqndr lrgthgslal ksfligvfth 121 qivdvswhsl vtdyrmhgll rvlsetefdg dietahtfld vmgefltlnn virdsnnnen 181 wdfltrsdwk lpreedlmei irnaglskek lsyaelefcv krgmaaaise gylfrsqrnq 241 lltniystsp randlilnhw lggqsnlvam lqrcvpffet lfhdentnea qaeelrlcan 301 lppvsqkrin arplvsslka rkgnshivvs pmksfsdfgt sltmgkfred nkdylavsap 361 ledtvgaiyi vpwdiltvar kedfsilqpi tamygskvgt ykasdvdyll vsqpgtctid 421 fyfkgvkilt ikdetteeah qlqfavtgnf yddkipdlvv sspsyganet giatfipgss 481 iisyltnsdk yqvvdistfk gvinldgypm kipfqhfgat iqisdttdkq kliyitcqsl 541 gtvfvyssnd lhdlsipiyy itkngvipak dsdhvewhii pskehgmfga aiyswnfegm 601 sfvavsqpmf dtvfiyieks gqiefflklv lkiktksdsi pdefgssllf ndeekklyvs 661 spgsfdargs iwkismdell kagndpkrkt llinnlrhlm linpdksskg vsnfgnsmil 721 gpqnhlivgi pqygygnfdh mqltgrilvl // LOCUS NP_012404 356 aa linear PLN 30-JUN-2025 DEFINITION Aim23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012404 VERSION NP_012404.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181564.1 REFERENCE 1 (residues 1 to 356) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 356) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 356) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 356) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08670. Method: conceptual translation. FEATURES Location/Qualifiers source 1..356 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..356 /product="Aim23p" /calculated_mol_wt="41330" Region 93..260 /region_name="mIF3" /note="Mitochondrial translation initiation factor; pfam14877" /db_xref="CDD:405550" CDS 1..356 /gene="AIM23" /locus_tag="YJL131C" /gene_synonym="MIF3" /coded_by="NM_001181564.1:1..1071" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:30927524]" /experiment="EXISTENCE:genetic interaction:GO:0070124 mitochondrial translational initiation [PMID:23954798]" /note="Mitochondrial translation initiation factor 3 (IF3, mIF3); evolutionarily conserved; interacts with mitochondrial ribosomal small subunit; binds to E. coli ribosomes in vitro; null mutant displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss" /db_xref="GeneID:853310" /db_xref="SGD:S000003667" ORIGIN 1 mlkvplsdvl sqkmlflksf ryfhctkyfs rdnassttdi frnamkrkre lanlkeqshg 61 nvarnaafpk eyikrpkqvp rnatnrkkil itwstgtdra keaansvvse ifkknhkgni 121 kvvdptthri easniryfak gidldkvgls ivnveqidne nqiplvkive srvalkkysd 181 flakkkekel melgvlnksy knlvtdkked nlkhikiswq iesddlkrqk aheivsllkk 241 gnkvtlyldd knninsnnwl enfeeldrsq kgepprlpes vfqkraavle tlkeivseya 301 ndpvllgnmn skmimklipk dvkpqnndkr alkelrkker qeklqkriqr kkmnem // LOCUS NP_012405 2214 aa linear PLN 30-JUN-2025 DEFINITION bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012405 VERSION NP_012405.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181563.2 REFERENCE 1 (residues 1 to 2214) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2214) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2214) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 2214) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08671. On Apr 26, 2011 this sequence version replaced NP_012405.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2214 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..2214 /product="bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase" /EC_number="2.1.3.2" /EC_number="6.3.5.5" /EC_number="3.5.1.2" /EC_number="6.3.4.16" /calculated_mol_wt="244911" Region 23..409 /region_name="CPSaseIIsmall" /note="carbamoyl-phosphate synthase, small subunit; TIGR01368" /db_xref="CDD:273580" Region 439..1485 /region_name="CPSaseII_lrg" /note="carbamoyl-phosphate synthase, large subunit; TIGR01369" /db_xref="CDD:273581" Region 1503..1830 /region_name="metallo-dependent_hydrolases" /note="Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; cl00281" /db_xref="CDD:469705" Site order(1514,1516,1632,1656,1720) /site_type="active" /db_xref="CDD:238617" Region 1906..2213 /region_name="PyrB" /note="Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; COG0540" /db_xref="CDD:440306" CDS 1..2214 /gene="URA2" /locus_tag="YJL130C" /coded_by="NM_001181563.2:1..6645" /experiment="EXISTENCE:direct assay:GO:0004070 aspartate carbamoyltransferase activity [PMID:10446140]" /experiment="EXISTENCE:direct assay:GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [PMID:5776390]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11015727]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:181668]" /experiment="EXISTENCE:direct assay:GO:0006541 glutamine metabolic process [PMID:5651325]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11921093]" /experiment="EXISTENCE:direct assay:GO:0045984 negative regulation of pyrimidine nucleobase metabolic process [PMID:5651325]" /experiment="EXISTENCE:mutant phenotype:GO:0004070 aspartate carbamoyltransferase activity [PMID:4550660]" /experiment="EXISTENCE:mutant phenotype:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:4550660]" /note="Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP" /db_xref="GeneID:853311" /db_xref="SGD:S000003666" ORIGIN 1 matiaptapi tppmestgdr lvtlelkdgt vlqgysfgae ksvagelvfq tgmvgypesv 61 tdpsyegqil vityplvgny gvpdmhlrde lveelpryfe snrihiaglv ishytdeysh 121 ylaksslgkw lqnegipavy gvdtrsltkh lrdagsmlgr lsleksgsdr tisrssswrs 181 afdvpewvdp nvqnlvskvs inepklyvpp adnkhielqt gpdgkvlril aidvgmkynq 241 ircfikrgve lkvvpwnydf tkedydglfi sngpgdpsvl ddlsqrlsnv leakktpvfg 301 iclghqliar aagastlklk fgnrghnipc tstisgrcyi tsqnhgfavd vdtltsgwkp 361 lfvnanddsn egiyhselpy fsvqfhpest pgprdteflf dvfiqavkef kytqvlkpia 421 fpggllednv kahprieakk vlvlgsggls igqagefdys gsqaikalke egiytilinp 481 niatiqtskg ladkvyfvpv taefvrkvil herpdaiyvt fggqtalsvg iamkdefeal 541 gvkvlgtpid tiittedrel fsnaideine kcaksqaans vdealaavke igfpvivraa 601 yalgglgsgf annekelvdl cnvafssspq vlveksmkgw keveyevvrd afdncitvcn 661 menfdplgih tgdsivvaps qtlsdedynm lrttavnvir hlgvvgecni qyalnpvskd 721 yciievnarl srssalaska tgyplaytaa klglniplne vknsvtkstc acfepsldyc 781 vvkmprwdlk kftrvstels ssmksvgevm sigrtfeeai qkairsteya nlgfnetdld 841 ididyelnnp tdmrvfaian afakkgysvd kvwemtridk wflnklhdlv qfaekissfg 901 tkeelpslvl rqakqlgfdd rqiarfldsn evairrlrke ygitpfvkqi dtvaaefpay 961 tnylymtyna dshdlsfddh gvmvlgsgvy rigssvefdw cavtavrtlr anniktimvn 1021 ynpetvstdy deadrlyfet inlervldiy eienssgvvv smggqtsnni amtlhrenvk 1081 ilgtspdmid saenrykfsr mldqigvdqp awkeltsmde aesfaekvgy pvlvrpsyvl 1141 sgaamntvys kndlesylnq avevsrdypv vitkyienak eiemdavarn gelvmhvvse 1201 hvenagvhsg datlivppqd lapetvdriv vatakigkal kitgpyniqf iakdneikvi 1261 ecnvrasrsf pfiskvvgvn lielatkaim glpltpypve klpddyvavk vpqfsfprla 1321 gadpvlgvem astgevatfg hskyeaylks llatgfklpk knillsigsy kekqellssv 1381 qklynmgykl fatsgtadfl sehgiavqyl evlnkddddq kseysltqhl anneidlyin 1441 lpsanrfrrp asyvskgykt rrlavdysvp lvtnvkcakl lieaisrnit ldvserdaqt 1501 shrtitlpgl iniatyvpna shvikgpael kettrlfles gftycqlmpr sisgpvitdv 1561 aslkaansvs qdssytdfsf tiagtahnah svtqsaskvt alflplrelk nkitavaell 1621 nqwptekqvi aeaktadlas vllltslqnr sihitgvsnk edlalimtvk akdprvtcdv 1681 niyslfiaqd dypeavflpt kedqeffwnn ldsidafsvg alpvalanvt gnkvdvgmgi 1741 kdslplllaa veegkltidd ivlrlhdnpa kifniptqds vveidldysf rrnkrwspfn 1801 kdmnggierv vyngetlvls gelvspgakg kcivnpspas itasaelqst sakrrfsite 1861 eaiadnldaa edaipeqple qklmssrppr elvapgaiqn lirsnnpfrg rhilsikqfk 1921 rsdfhvlfav aqelraavar egvldlmkgh vittiffeps trtcssfiaa merlggrivn 1981 vnplvssvkk getlqdtirt lacysdaivm rhseemsvhi aakyspvpii nggngsrehp 2041 tqafldlfti reeigtvngi tvtfmgdlkh grtvhslcrl lmhyqvrinl vsppelrlpe 2101 glreelrkag llgvesielt phiisktdvl yctrvqeerf nspeeyarlk dtyivdnkil 2161 ahakenmaim hplprvneik eevdydhraa yfrqmkyglf vrmallamvm gvdm // LOCUS NP_012406 1235 aa linear PLN 30-JUN-2025 DEFINITION Trk1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012406 VERSION NP_012406.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181562.1 REFERENCE 1 (residues 1 to 1235) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1235) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1235) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08672. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1235 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1235 /product="Trk1p" /calculated_mol_wt="140943" Region 3..1173 /region_name="2a38euk" /note="potassium uptake protein, Trk family; TIGR00934" /db_xref="CDD:130009" CDS 1..1235 /gene="TRK1" /locus_tag="YJL129C" /coded_by="NM_001181562.1:1..3708" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16166647]" /experiment="EXISTENCE:direct assay:GO:0015079 potassium ion transmembrane transporter activity [PMID:3043197]" /experiment="EXISTENCE:direct assay:GO:0030007 intracellular potassium ion homeostasis [PMID:3043197]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:16166647]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:33640956]" /note="Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p activity is regulated by phosphorylation; TRK1 has a paralog, TRK2, that arose from the whole genome duplication" /db_xref="GeneID:853312" /db_xref="SGD:S000003665" ORIGIN 1 mhfrrtmsrv ptlasleiry kksfghkfrd fialcghyfa pvkkyifpsf iavhyfytis 61 ltlitsilly pikntryidt lflaagavtq gglntvdinn lslyqqivly ivccistpia 121 vhsclafvrl ywferyfdgi rdssrrnfkm rrtktilere ltartmtknr tgtqrtsypr 181 kqaktddfqe klfsgemvnr deqdsvhsdq nshdisrdss nnntnhngss gslddfvked 241 etddngeyqe nnsystvgss sntvadesln qkpkpsslrf dephskqrpa rvpsekfakr 301 rgsrdispad myrsimmlqg kheataedeg pplvigspad gtryksnvnk lkkatgingn 361 kikirdkgne sntdqnsvss eanstasvsd esslhtnfgn kvpslrtnth rsnsgpiait 421 dnaetdkkhg psiqfditkp prkiskrvst fddlnpkssv lyrkkaskky lmkhfpkarr 481 irqqikrrls tgsieknssn nvsdrkpitd mddddddddn dgdnneeyfa dnesgdeder 541 vqqsephsds elkshqqqqe khqlqqnlhr myktksfddn rsravpmers rtidmaeakd 601 lnelartpdf qkmvyqnwka hhrkkpnfrk rgwnnkifeh gpyasdsdrn ypdnsntgns 661 ilhyaesilh hdgshkngse eassdsneni ystnggsdhn glnnyptynd deegyyglhf 721 dtdydldprh dlskgsgkty lswqptigrn snflgltraq kdelggveyr aikllctilv 781 vyyvgwhiva fvmlvpwiil kkhysevvrd dgvsptwwgf wtamsafndl gltltpnsmm 841 sfnkavypli vmiwfiiign tgfpillrci iwimfkispd lsqmreslgf lldhprrcft 901 llfpkaatww llltlaglni tdwilfiild fgstvvksls kgyrvlvglf qsvstrtagf 961 svvdlsqlhp siqvsymlmm yvsvlplais irrtnvyeeq slglygdmgg epedtdtedd 1021 gndedddeen eshegqssqr sssnnnnnnn rkkkkkkkte npneistksf igahlrkqls 1081 fdlwflflgl fiicicegdk ikdvqepnfn ifailfeivs aygtvglslg ypdtnqsfsr 1141 qfttlsklvi iamlirgknr glpysldrai ilpsdrlehi dhlegmklkr qartntedpm 1201 tehfkrsftd vkhrwgalkr ktthsrnpkr ssttl // LOCUS NP_012407 668 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase kinase PBS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012407 VERSION NP_012407.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181561.2 REFERENCE 1 (residues 1 to 668) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 668) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 668) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 668) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08673. On Apr 26, 2011 this sequence version replaced NP_012407.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..668 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..668 /product="mitogen-activated protein kinase kinase PBS2" /EC_number="2.7.12.2" /calculated_mol_wt="72589" Region 358..644 /region_name="PKc_PBS2_like" /note="Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; cd06622" /db_xref="CDD:132953" Site order(366..370,374,387,389,419,435..438,441..442,445,485, 487..490,492,503..504,507,519..522,524,556,565) /site_type="active" /db_xref="CDD:132953" Site order(366..370,372,374,387,389,419,435..438,441..442, 444..445,487,489..490,492,504) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:132953" Site order(369..370,485,487..489,507,519..522,524,556,565) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:132953" Site 503..524 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:132953" CDS 1..668 /gene="PBS2" /locus_tag="YJL128C" /gene_synonym="HOG4; SFS4; SSK4" /coded_by="NM_001181561.2:1..2007" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9755161]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10980703]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10980703]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0038066 p38MAPK cascade [PMID:7624781]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:7624781]" /experiment="EXISTENCE:mutant phenotype:GO:0004708 MAP kinase kinase activity [PMID:7624781]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:15707964]" /experiment="EXISTENCE:mutant phenotype:GO:0006972 hyperosmotic response [PMID:7681220]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:7941729]" /experiment="EXISTENCE:mutant phenotype:GO:0007231 osmosensory signaling pathway [PMID:7624781]" /experiment="EXISTENCE:mutant phenotype:GO:0038066 p38MAPK cascade [PMID:15707964]" /experiment="EXISTENCE:physical interaction:GO:0005078 MAP-kinase scaffold activity [PMID:9180081|PMID:15200958|PMID:15200959]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:14685261]" /experiment="EXISTENCE:physical interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:15200958]" /note="MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; regulates late-stage macroautophagy after autophagosome closure and mitophagy; plays a role in regulating Ty1 transposition" /db_xref="GeneID:853313" /db_xref="SGD:S000003664" ORIGIN 1 medkfanlsl hektgkssiq lneqtgsdng savkrtssts shynninadl harvkafqeq 61 ralkrsasvg snqseqdkgs sqspkhiqqi vnkplpplpv agsskvsqrm ssqvvqassk 121 stlknvldnq etqnitdvni nidttkitat tigvntglpa tditpsvsnt asathkaqll 181 npnrraprrp lstqhptrpn vaphkapaii ntpkqslsar rglklppggm slkmptktaq 241 qpqqfapsps nkkhietlsn skvvegkrsn pgslingvqs tstssstegp hdtvgttprt 301 gnsnnssnsg ssgggglfan fskyvdiksg slnfagklsl sskgidfsng sssritldel 361 efldelghgn ygnvskvlhk ptnvimatke vrleldeakf rqilmelevl hkcnspyivd 421 fygaffiega vymcmeymdg gsldkiydes seiggidepq lafianavih glkelkeqhn 481 iihrdvkptn ilcsanqgtv klcdfgvsgn lvaslaktni gcqsymaper ikslnpdrat 541 ytvqsdiwsl glsilemalg rypyppetyd nifsqlsaiv dgppprlpsd kfssdaqdfv 601 slclqkiper rptyaalteh pwlvkyrnqd vhmseyiter lerrnkilre rgenglsknv 661 palhmggl // LOCUS NP_878103 52 aa linear PLN 30-JUN-2025 DEFINITION Mco6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878103 VERSION NP_878103.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184532.1 REFERENCE 1 (residues 1 to 52) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 52) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 52) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 52) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08674. Method: conceptual translation. FEATURES Location/Qualifiers source 1..52 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..52 /product="Mco6p" /calculated_mol_wt="5886" Region 5..48 /region_name="Emr1" /note="ERMES regulator 1; pfam17237" /db_xref="CDD:435804" CDS 1..52 /gene="MCO6" /locus_tag="YJL127C-B" /gene_synonym="YJL127C-A" /coded_by="NM_001184532.1:1..159" /experiment="EXISTENCE:direct assay:GO:0001401 SAM complex [PMID:38377000]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:28658629]" /experiment="EXISTENCE:genetic interaction:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:38377000]" /experiment="EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:38377000]" /note="Mitochondrial outer membrane protein protein; co-assembles with Mdm10p into the mitochondrial sorting and assembly machinery (SAM) complex and cooperates with Mdm10p in the assembly of the translocase of the outer membrane (TOM) complex; identified based on homology to the filamentous fungus, Ashbya gossypii; SWAT-GFP and seamless-GFP fusion proteins localize to the mitochondria" /db_xref="GeneID:1466466" /db_xref="SGD:S000028522" ORIGIN 1 mifffnqirs iftalhtptq qiqlsrraff qflgylgscv vislaaqsky vq // LOCUS NP_012408 640 aa linear PLN 30-JUN-2025 DEFINITION Spt10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012408 VERSION NP_012408.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181560.1 REFERENCE 1 (residues 1 to 640) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 640) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 640) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 640) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08675. Method: conceptual translation. FEATURES Location/Qualifiers source 1..640 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..640 /product="Spt10p" /calculated_mol_wt="72791" Region <168..267 /region_name="MnaT" /note="L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism]; COG1247" /db_xref="CDD:440860" Region 351..389 /region_name="zf-H2C2" /note="H2C2 zinc finger; pfam09337" /db_xref="CDD:430537" CDS 1..640 /gene="SPT10" /locus_tag="YJL127C" /gene_synonym="CRE1; SUD1" /coded_by="NM_001181560.1:1..1923" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:16199888]" /experiment="EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:15882620]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:21057056]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17526727]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:21057056]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:17078097]" /experiment="EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:26649943]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:21057056]" /note="Histone H3 acetylase with a role in transcriptional regulation; sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near TATA box; involved in S phase-specific acetylation of H3K56 at histone promoters, which is required for recruitment of SWI/SNF nucleosome remodeling complex and subsequent transcription" /db_xref="GeneID:853315" /db_xref="SGD:S000003663" ORIGIN 1 mlnqhtssvp ddehlqmahq nsssevrnea avpdqlltpl qpytillkdg etiatmypip 61 aypdllplgl lnflldefnm evekgdsfpy yetlsleefk nvwfhndghv cimvlgeipe 121 ldysmdtead tndnfgteie ttkhttqykk rkerrnlnls mqwekqclgi fdlkpaypgr 181 sahvvtgtfl vnagirgkgi gktlmetfie wskklgftss ffpliygtnv girrilegln 241 frrigklpea gilkgfdvpv dsfmygkeft hitksidllr dpqksieigk yerlkhflet 301 gkyplhcdrn ekarlrvlsk thsvlngklm tkgkeiiydt dqqiqialei hlmehlgink 361 vtskigekyh wrgikstvse visrcqkckm rykdgtgvii eqkravkqah mlptqhieti 421 nnprkskkhd nallgqainf pqniisstln dvegeptppd tnivqptfqn atnspattae 481 aneankrsef lssiqstpll ddeqsmnsfn rfveeensrk rrkyldvasn givphltnne 541 sqdhanpvnr derdmnhsvp dldrndhtim ndamlsledn vmaalemvqk eqqqkinhrg 601 edvtgqqidl nnsegnensv tkivnnesnt ftehnsniyy // LOCUS NP_012409 307 aa linear PLN 30-JUN-2025 DEFINITION putative hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012409 VERSION NP_012409.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181559.1 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 307) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08676. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..307 /product="putative hydrolase" /EC_number="3.5.1.128" /calculated_mol_wt="34562" Region 7..302 /region_name="nit" /note="Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); cd07572" /db_xref="CDD:143596" Site order(45,110,127,131,143,169..170,172..173,194) /site_type="active" /note="putative active site [active]" /db_xref="CDD:143596" Site order(45,127,169) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:143596" Site order(128..129,149..151,170,173..177,179..180,202..203, 206..207,209..211,213..214,262,295..296,299..300,302) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:143596" CDS 1..307 /gene="NIT2" /locus_tag="YJL126W" /coded_by="NM_001181559.1:1..924" /experiment="EXISTENCE:direct assay:GO:0043605 amide catabolic process [PMID:28373563]" /experiment="EXISTENCE:direct assay:GO:0110050 deaminated glutathione amidase activity [PMID:28373563]" /note="Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" /db_xref="GeneID:853316" /db_xref="SGD:S000003662" ORIGIN 1 mtsklkrvav aqlcssadlt knlkvvkeli seaiqkkadv vflpeasdyl sqnplhsryl 61 aqkspkfirq lqssitdlvr dnsrnidvsi gvhlppseqd llegndrvrn vllyidhegk 121 ilqeyqklhl fdvdvpngpi lkesksvqpg kaipdiiesp lgklgsaicy dirfpefslk 181 lrsmgaeilc fpsaftiktg eahwellgra ravdtqcyvl mpgqvgmhdl sdpewekqsh 241 msalekssrr eswghsmvid pwgkiiahad pstvgpqlil adldrellqe irnkmplwnq 301 rrddlfh // LOCUS NP_012410 383 aa linear PLN 30-JUN-2025 DEFINITION tRNA 1-methyladenosine methyltransferase subunit GCD14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012410 VERSION NP_012410.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181558.1 REFERENCE 1 (residues 1 to 383) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 383) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 383) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 383) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08677. Method: conceptual translation. FEATURES Location/Qualifiers source 1..383 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..383 /product="tRNA 1-methyladenosine methyltransferase subunit GCD14" /EC_number="2.1.1.220" /calculated_mol_wt="43789" Region 72..363 /region_name="AdoMet_MTases" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl17173" /db_xref="CDD:473071" CDS 1..383 /gene="GCD14" /locus_tag="YJL125C" /gene_synonym="TRM61" /coded_by="NM_001181558.1:1..1152" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9851972]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:10779558]" /experiment="EXISTENCE:direct assay:GO:0031515 tRNA (m1A) methyltransferase complex [PMID:10779558]" /experiment="EXISTENCE:direct assay:GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity [PMID:10779558]" /experiment="EXISTENCE:mutant phenotype:GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity [PMID:10779558]" /experiment="EXISTENCE:physical interaction:GO:0031515 tRNA (m1A) methyltransferase complex [PMID:10779558]" /note="Subunit of tRNA (1-methyladenosine) methyltransferase; required, along with Gcd10p, for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression" /db_xref="GeneID:853317" /db_xref="SGD:S000003661" ORIGIN 1 mstncfsgyk dlikegdltl iwvsrdnikp vrmhseevfn trygsfphkd iigkpygsqi 61 airtkgsnkf afvhvlqptp elwtlslphr tqivytpdss yimqrlncsp hsrvieagtg 121 sgsfshafar svghlfsfef hhiryeqale efkehglidd nvtithrdvc qggflikkgd 181 ttsyefgnne taaslnanvv fldlpapwda iphldsvisv dekvglccfs pcieqvdktl 241 dvlekygwtd vemveiqgrq yesrrqmvrs lndalerlrd ikrhklqgve rrkrmfnnti 301 dsndekvgkr nedgvpltek akfnpfgkgs rikegdsnyk wkevtkmeae ikshtsyltf 361 afkvvnrsrd dekvneilrs tek // LOCUS NP_012411 172 aa linear PLN 30-JUN-2025 DEFINITION Lsm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012411 VERSION NP_012411.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181557.1 REFERENCE 1 (residues 1 to 172) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 172) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 172) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 172) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08678. Method: conceptual translation. FEATURES Location/Qualifiers source 1..172 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..172 /product="Lsm1p" /calculated_mol_wt="20176" Region 40..115 /region_name="LSm1" /note="Like-Sm protein 1; cd01728" /db_xref="CDD:212475" Site order(46,49..50,55,57..59,62,64,69..72,75..76,78,101..113) /site_type="other" /note="putative oligomer interface [polypeptide binding]" /db_xref="CDD:212475" Site order(54..60,62..74,76..80) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212475" Site order(72,74,105) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:212475" Site 101..112 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212475" CDS 1..172 /gene="LSM1" /locus_tag="YJL124C" /gene_synonym="SPB8" /coded_by="NM_001181557.1:1..519" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:18611963|PMID:12730603]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18029398|PMID:23706738|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:10747033]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:10761922]" /experiment="EXISTENCE:mutant phenotype:GO:0000932 P-body [PMID:12730603]" /note="Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; also enters the nucleus and positively regulates transcription initiation; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; binds to mRNAs under glucose starvation, most often in the 3' UTR; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:853318" /db_xref="SGD:S000003660" ORIGIN 1 msanskdrnq snqdakrqqq nfpkkisege adlyldqynf tttaaivssv drkifvllrd 61 grmlfgvlrt fdqyanlilq dcveriyfse enkyaeedrg ifmirgenvv mlgevdidke 121 dqpleameri pfkeawltkq kndekrfkee thkgkkmarh givydfhksd my // LOCUS NP_012412 478 aa linear PLN 30-JUN-2025 DEFINITION DUF5427 domain-containing protein MTC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012412 VERSION NP_012412.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181556.1 REFERENCE 1 (residues 1 to 478) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 478) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 478) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08679. Method: conceptual translation. FEATURES Location/Qualifiers source 1..478 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..478 /product="DUF5427 domain-containing protein MTC1" /calculated_mol_wt="53346" Region 14..477 /region_name="DUF5427" /note="Family of unknown function (DUF5427); pfam10310" /db_xref="CDD:431211" CDS 1..478 /gene="MTC1" /locus_tag="YJL123C" /coded_by="NM_001181556.1:1..1437" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31323700]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /note="hypothetical protein that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1" /db_xref="GeneID:853319" /db_xref="SGD:S000003659" ORIGIN 1 msenknseae dvfefldslp eaknggkmvn tdvkgsqegv kggsnsvagk tgndgkkgdd 61 difefleele ksnlsltdkk gvekkapses vnnkaqdekv eeskenknse qdahgkekep 121 qqqekeeeee eeeeeeeeee etplhdpias isnwwsssgs akvssiwnkt aeqasqiknr 181 laqeqldlts kintstitei arnlqkivvg eteevlrihl vhdlvnypsl qynieskfdq 241 vlssqveggi rifvdewghp nnngitpvek kpsvadgelg nskkklqfnl fdgkvtdgek 301 lafanlenav klfntaheey qkqqkeadat pdddrssiss nsnkisdlfi silpiaipqk 361 qkdadgdfqv tdsntpgnfn ftlvlkditn dittitrsqg fpvkwvnwle gsvektgsta 421 seernksydq kkqkeseded eddeiidpse wvkewiedgl slsfgvmaqn yvidrmgl // LOCUS NP_012413 175 aa linear PLN 30-JUN-2025 DEFINITION Alb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012413 VERSION NP_012413.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181555.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 175) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08680. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..175 /product="Alb1p" /calculated_mol_wt="19156" Region 1..118 /region_name="Alb1" /note="pfam09135" /db_xref="CDD:430427" CDS 1..175 /gene="ALB1" /locus_tag="YJL122W" /coded_by="NM_001181555.1:1..528" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:16651379]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16651379]" /experiment="EXISTENCE:genetic interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:16651379]" /experiment="EXISTENCE:physical interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:16651379]" /note="Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p" /db_xref="GeneID:853320" /db_xref="SGD:S000003658" ORIGIN 1 mpsknsinrp kltsnlhhkv hslnkkraqr eragllkpar ssvnsksgei ksvaldlyfq 61 nkknesqnst avtlqnasss pasittrtls kkrakkiern lkyatqrkll vdasaklede 121 mdidldggkk vkenekkssl tlvkealwsv iddtasqgli iengqgttlg gpffp // LOCUS NP_012414 238 aa linear PLN 30-JUN-2025 DEFINITION ribulose-phosphate 3-epimerase RPE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012414 VERSION NP_012414.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181554.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 238) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08681. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..238 /product="ribulose-phosphate 3-epimerase RPE1" /EC_number="5.1.3.1" /calculated_mol_wt="25836" Region 3..234 /region_name="PTZ00170" /note="D-ribulose-5-phosphate 3-epimerase; Provisional" /db_xref="CDD:240303" Site order(9,11,36,82,155..156,158..159,185,187,207..208) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238244" Site order(16,19,39,41..42,44,46..49,85,89,110,112..113,131,134, 136,140,154,163,165,169) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:238244" Site order(34,36,80,185) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:238244" CDS 1..238 /gene="RPE1" /locus_tag="YJL121C" /gene_synonym="EPI1; POS18" /coded_by="NM_001181554.1:1..717" /experiment="EXISTENCE:direct assay:GO:0004750 D-ribulose-phosphate 3-epimerase activity [PMID:8929392]" /experiment="EXISTENCE:mutant phenotype:GO:0004750 D-ribulose-phosphate 3-epimerase activity [PMID:8929392]" /experiment="EXISTENCE:mutant phenotype:GO:0006098 pentose-phosphate shunt [PMID:8929392]" /note="D-ribulose-5-phosphate 3-epimerase; catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress" /db_xref="GeneID:853322" /db_xref="SGD:S000003657" ORIGIN 1 mvkpiiapsi lasdfanlgc echkvinaga dwlhidvmdg hfvpnitlgq pivtslrrsv 61 prpgdasnte kkptaffdch mmvenpekwv ddfakcgadq ftfhyeatqd plhlvkliks 121 kgikaacaik pgtsvdvlfe laphldmalv mtvepgfggq kfmedmmpkv etlrakfphl 181 niqvdgglgk etipkaakag anvivagtsv ftaadphdvi sfmkeevske lrsrdlld // LOCUS NP_012417 219 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL118W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012417 VERSION NP_012417.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181551.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 219) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08682. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..219 /product="uncharacterized protein" /calculated_mol_wt="25467" CDS 1..219 /locus_tag="YJL118W" /coded_by="NM_001181551.1:1..660" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; YJL118W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein" /db_xref="GeneID:853323" /db_xref="SGD:S000003654" ORIGIN 1 mascfsvsll arvavvepir vqlwlnvvnc miessmhqcp prdrhffsss rpillirrsv 61 stvyrfvasr ttqvlraakt vvkwfiivdp linsilinyl idrlctlgha vlrvkkrkte 121 erqpcspiiq hthvkrrkrp rlrivaikrk rrrrrphrie rplsnmypim eiqmvavpla 181 lpsptalvhy qqqqqqlpqh hpwydlslse ealstcccs // LOCUS NP_012418 311 aa linear PLN 30-JUN-2025 DEFINITION Pho86p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012418 VERSION NP_012418.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181550.1 REFERENCE 1 (residues 1 to 311) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 311) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 311) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 311) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08683. Method: conceptual translation. FEATURES Location/Qualifiers source 1..311 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..311 /product="Pho86p" /calculated_mol_wt="34751" Region 22..303 /region_name="Pho86" /note="Inorganic phosphate transporter chaperone Pho86; pfam11124" /db_xref="CDD:463226" CDS 1..311 /gene="PHO86" /locus_tag="YJL117W" /coded_by="NM_001181550.1:1..936" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10655492|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15623581]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10655492]" /experiment="EXISTENCE:mutant phenotype:GO:0010966 regulation of phosphate transport [PMID:10655492]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:15623581]" /note="Endoplasmic reticulum (ER) resident protein; required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853325" /db_xref="SGD:S000003653" ORIGIN 1 mavqqrkkke grksdknaps vpqvdasldk pldidappti ysvnlkpeyg taalnlsadf 61 irqeqalank ylffhpvilv vltiglliyl tprivfpirn tgsvagwfyq larinkkvvl 121 sglvftaiga sflftllsrv sdsyfkskin qlvgskgekv fginlndlva rhetkdpvvn 181 nthiivyret pialislapn mtlstdenlv msvttvgcrr vyvksgiied lidwamlhsk 241 nirssgkyge tmkllidvys fdstlkeilk kkgftyiqsi rvsenrllgg lfgvkkelwg 301 lqfhfkaehk d // LOCUS NP_012419 337 aa linear PLN 30-JUN-2025 DEFINITION SUN family protein NCA3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012419 VERSION NP_012419.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181549.1 REFERENCE 1 (residues 1 to 337) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 337) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 337) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 337) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08684. Method: conceptual translation. FEATURES Location/Qualifiers source 1..337 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..337 /product="SUN family protein NCA3" /calculated_mol_wt="35281" Region 83..324 /region_name="SUN" /note="Beta-glucosidase (SUN family); pfam03856" /db_xref="CDD:427547" CDS 1..337 /gene="NCA3" /locus_tag="YJL116C" /coded_by="NM_001181549.1:1..1014" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0042776 proton motive force-driven mitochondrial ATP synthesis [PMID:7586026]" /note="Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the vacuole; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication" /db_xref="GeneID:853326" /db_xref="SGD:S000003652" ORIGIN 1 mkisaalils slssvafsap apapadshhe dhhkdekpav vtvtqyidsn aatstvesaa 61 ttttlsssek dtseqkrdgg fqdgtvkcsd fpsvngivsl dwlgfggwas vmdmdantss 121 eckdgyycsy acepgmsktq wpsdqpsdgk svgglyckng ylyrtntdts dlcstdetsa 181 kainkksdsi alcrtdypgs enmviptvvd ggdsqpisvv dedtyyqwqg kktsaqyyin 241 nagvsaedgc iwgtsgsdvg nwaplvlgag stngetylsl ipnpnsnqaa nfnvkivasd 301 ganvqgscay edgsftgdgs dgctvsvlsg saefvfy // LOCUS NP_012420 279 aa linear PLN 30-JUN-2025 DEFINITION nucleosome assembly factor ASF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012420 VERSION NP_012420.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181548.1 REFERENCE 1 (residues 1 to 279) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 279) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 279) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 279) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08685. Method: conceptual translation. FEATURES Location/Qualifiers source 1..279 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..279 /product="nucleosome assembly factor ASF1" /calculated_mol_wt="31472" Region 1..154 /region_name="ASF1_hist_chap" /note="ASF1 like histone chaperone; pfam04729" /db_xref="CDD:461412" CDS 1..279 /gene="ASF1" /locus_tag="YJL115W" /gene_synonym="CIA1" /coded_by="NM_001181548.1:1..840" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:11404324]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:16303565]" /experiment="EXISTENCE:direct assay:GO:0006335 DNA replication-dependent chromatin assembly [PMID:11412995]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:22308335]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:15840725]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:15840725]" /experiment="EXISTENCE:mutant phenotype:GO:0001932 regulation of protein phosphorylation [PMID:27222517]" /experiment="EXISTENCE:mutant phenotype:GO:0006337 nucleosome disassembly [PMID:16678113]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19620280]" /experiment="EXISTENCE:mutant phenotype:GO:0010468 regulation of gene expression [PMID:26941319]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:19620280]" /experiment="EXISTENCE:mutant phenotype:GO:0042393 histone binding [PMID:15840725]" /note="Nucleosome assembly factor; involved in chromatin assembly, disassembly; required for recovery after DSB repair; role in H3K56 acetylation required for expression homeostasis, buffering mRNA synthesis rate against gene dosage changes in S phase; anti-silencing protein, derepresses silent loci when overexpressed; role in regulating Ty1 transposition; relocalizes to cytosol under hypoxia; growth defect of asf1 null is functionally complemented by either human ASF1A or ASF1B" /db_xref="GeneID:853327" /db_xref="SGD:S000003651" ORIGIN 1 msivsllgik vlnnpakftd pyefeitfec leslkhdlew kltyvgssrs ldhdqeldsi 61 lvgpvpvgvn kfvfsadpps aelipaselv svtvillscs ydgrefvrvg yyvnneydee 121 elrenppakv qvdhivrnil aekprvtrfn ivwdnenegd lyppeqpgvd deeeeddeee 181 dddeddedde dddqedgege aeeaaeeeee eeektednet nleeeeedie nsdgdeeege 241 eevgsvdkne dgndkkrrki eggstdiest pkdaarstn // LOCUS NP_012422 226 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012422 VERSION NP_012422.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181547.2 REFERENCE 1 (residues 1 to 226) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 226) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 226) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08687. On Apr 26, 2011 this sequence version replaced NP_012422.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..226 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..226 /product="gag protein" /calculated_mol_wt="26227" CDS 1..226 /locus_tag="YJL114W" /coded_by="NM_001181547.2:1..681" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:853329" /db_xref="SGD:S000003650" ORIGIN 1 matpvrgetr nviddnisar iqskvktndt vrqtpsslrk vsikdeqvrq yqrnlnrfkt 61 ilnglkaeee klseaddiqm laekllklge tidkvenriv dlvekiqlle tnennnilhe 121 hidatgtyyl fdtltstnkr fypkdcvfdy rtnnvenipi llnnfkkfik kyqfddvfen 181 diieidpren eilckiikeg lgesldimnt nttdifriid glkkqi // LOCUS NP_012421 1548 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012421 VERSION NP_012421.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181546.3 REFERENCE 1 (residues 1 to 1548) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1548) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1548) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1548) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08686. On Apr 26, 2011 this sequence version replaced NP_012421.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1548 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1548 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="178047" Region 369..469 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1068..1278 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1386..1523 /region_name="RNase_H_like" /note="Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; cl14782" /db_xref="CDD:449355" Site order(1390..1393,1428..1429,1432,1466,1506,1519) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:259998" CDS 1..1548 /locus_tag="YJL113W" /coded_by="join(NM_001181546.3:1..321, NM_001181546.3:323..4648)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:853330" /db_xref="SGD:S000003649" ORIGIN 1 mnklqklvlm ekwifskccq dcpnlkdylq eaimgtlhes lrnsvkqrly niphdvgidh 61 eeflintvie tvidlspiad dqienscmyc ksvfhcsinc kkkpnrelgl trpisqkpii 121 ykvhrdnnhl spvqneqksw nktqkrsnkv ynskklviid tgsgvnitnd ktllhnyeds 181 nrstrffgig knssvsvkgy gyikiknghn ntdnkcllty yvpeeestii scydlakktk 241 mvlsrkytrl gnkiikiktk ivngvihvkm nelierpsdd skinaikpts spgfklnkrs 301 itledahkrm ghtgiqqien sikhnhyees ldlikepnef wcqtckiska tkrnhytgsm 361 nnhstdhepg sswcmdifgp vsssnadtkr ymlimvdnnt rycmtsthfn knaetilaqv 421 rkniqyvetq fdrkvreins drgteftndq ieeyfiskgi hhiltstqdh aangraeryi 481 rtiitdattl lrqsnlrvkf weyavtsatn irnylehkst gklplkaisr qpvtvrlmsf 541 lpfgekgiiw nhnhkklkps glpsiilckd pnsygykffi psknkivtsd nytipnytmd 601 grvrntqnin kshqfssdnd deedqietvt nlcealenye ddnkpitrle dlfteeelsq 661 idsnakypsp snnlegdldy vfsdveesgd ydveselstt nnsistdknk ilsnkdfnse 721 lasteisisg idkkglints hidedkydek vhripsiiqe klvgskntik indenkisdr 781 irsknigsil ntglsrcvdi tdesitnkde smhnakpeli qeqlkktnhe tsfpkegsig 841 tnvkfrntnn eislktgdts lpiktlesin nhhsndystn kvekfekenh hpppiedivd 901 msdqtdmesn cqdgnnlkel kvtdknvptd ngtnvsprle qnieasgspv qtvnksafln 961 kefsslnmkr krkrhdknns ltsyelerdk krskknrvkl ipdnmetvsa pkiraiyyne 1021 aisknpdlke kheykqayhk elqnlkdmkv fdvdvkysrs eipdnlivpt ntiftkkrng 1081 iykarivcrg dtqspdtysv itteslnhnh ikiflmiann rnmfmktldi nhaflyakle 1141 eeiyiphphd rrcvvklnka lyglkqspke wndhlrqyln giglkdnsyt pglyqtedkn 1201 lmiavyvddc viaasneqrl definklksn felkitgtli ddvldtdilg mdlvynkrlg 1261 tidltlksfi nrmdkkynee lkkirkssip hmstykidpk kdvlqmseee frqgvlklqq 1321 llgelnyvrh kcrydiefav kkvarlvnyp hervfymiyk iiqylvrykd igihydrdcn 1381 kdkkviaitd asvgseydaq srigvilwyg mnifnvysnk stnrcvsste aelhaiyegy 1441 adsetlkvtl kelgegdnnd ivmitdskpa iqglnrsyqq pkekftwikt eiikekikek 1501 sikllkitgk gniadlltkp vsasdfkrfi qvlknkitsq dilastdy // LOCUS NP_012423 714 aa linear PLN 30-JUN-2025 DEFINITION Mdv1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012423 VERSION NP_012423.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181545.2 REFERENCE 1 (residues 1 to 714) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 714) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 714) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 714) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08688. Method: conceptual translation. FEATURES Location/Qualifiers source 1..714 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..714 /product="Mdv1p" /calculated_mol_wt="79901" Region 97..298 /region_name="Mdv1_N" /note="N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division protein 1 (Mdv1) and similar proteins; cd22881" /db_xref="CDD:467856" Region 123..171 /region_name="Mdv1" /note="Mitochondrial division protein 1; pfam11542" /db_xref="CDD:402923" Region 397..713 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(397,415,420,426..427,439..440,458,462,468..469, 500..501,516,521,527..528,541,580,585,591..592,604..605, 621,625,631..632,643..644,661,671..672,685..686,702,706, 712..713) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 402..439 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 444..499 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 506..539 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 546..603 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 648..683 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 690..712 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..714 /gene="MDV1" /locus_tag="YJL112W" /gene_synonym="GAG3; NET2" /coded_by="NM_001181545.2:1..2145" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:11038182|PMID:11038180|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:genetic interaction:GO:0000266 mitochondrial fission [PMID:11179417]" /experiment="EXISTENCE:genetic interaction:GO:0016559 peroxisome fission [PMID:18445678]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:11038182]" /experiment="EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:11179417|PMID:11038183|PMID:11038182|PMID:11038180]" /experiment="EXISTENCE:physical interaction:GO:0000266 mitochondrial fission [PMID:11038182|PMID:11179417]" /note="Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the self-assembled oligomeric form of the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication" /db_xref="GeneID:853332" /db_xref="SGD:S000003648" ORIGIN 1 msvndqithi gktlsttasa flnyqksnsn tqdvltnngp yknllsntvn nasstsyfyk 61 rtehgrfvkn asntfediys ktrrgdvfrn kftdnktcfr mltyisddll neiptkeglk 121 sdadgkllte ggenenlrkn askketslfq gfksylpiae laienterln ydtngtsgtv 181 gakdvmsktn erdeihtelp nfqdsflipp gvetkkisss yspsalksfs qtlvnslefl 241 niqknstlse irdieveven lrqkkekllg kianieqnql llednlkqid drldfleeyg 301 levieansde naeddgmser kalkndairn egvttesiss easnlpprrr qqlrddnsln 361 rlgafysksk krhrksfptf qqlyepgtki gsimsthddf ltcldfdapf gtlctagyld 421 htvkiwdlsk qnkigelagh latincmqin rdygtlvtgg rdaalklwnl nlaqqlyqet 481 qnltsptnhi dspcvhtfea htdevtalsl dpsflvsgsq drtirqwdlr sgkclqtidl 541 sfanvlttst nvdlskstll tqrnerpsig alqsfdaala tgtkdgvvrl wdlrsgkvir 601 tlkghtdait slkfdsaclv tgsydrtvri wdlrtgllnk fhaysapvls ldlfqenaav 661 vvadepsvqi ydsekdesws cveqgnetsv stvkykenym vegrengdvn iwav // LOCUS NP_012424 550 aa linear PLN 30-JUN-2025 DEFINITION chaperonin-containing T-complex subunit CCT7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012424 VERSION NP_012424.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181544.1 REFERENCE 1 (residues 1 to 550) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 550) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 550) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 550) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 550) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 550) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 550) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08689. Method: conceptual translation. FEATURES Location/Qualifiers source 1..550 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..550 /product="chaperonin-containing T-complex subunit CCT7" /calculated_mol_wt="59605" Region 9..529 /region_name="TCP1_eta" /note="TCP-1 (CTT or eukaryotic type II) chaperonin family, eta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL); cd03340" /db_xref="CDD:239456" Site order(17,21,49..52,54,72,74,78,82,85,383,519..525) /site_type="other" /note="ring oligomerisation interface [polypeptide binding]" /db_xref="CDD:239456" Site order(44..46,96,100,164,395,413,453,496,498) /site_type="other" /note="ATP/Mg binding site [chemical binding]" /db_xref="CDD:239456" Site order(433,451,460,462..463,466) /site_type="active" /note="stacking interactions [active]" /db_xref="CDD:239456" CDS 1..550 /gene="CCT7" /locus_tag="YJL111W" /gene_synonym="TCP7" /coded_by="NM_001181544.1:1..1653" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance" /db_xref="GeneID:853333" /db_xref="SGD:S000003647" ORIGIN 1 mnfgsqtpti vvlkegtdas qgkgqiisni nacvavqeal kptlgplgsd ilivtsnqkt 61 tisndgatil klldvvhpaa ktlvdisraq daevgdgtts vtilagelmk eakpfleegi 121 sshlimkgyr kavslaveki nelavditse kssgreller cartamsskl ihnnadffvk 181 mcvdavlsld rndlddklig ikkipggame eslfingvaf kktfsyagfe qqpkkfnnpk 241 ilslnvelel kaekdnaevr vehvedyqai vdaewqlife klrqveetga nivlsklpig 301 dlatqffadr nifcagrvsa ddmnrviqav ggsiqsttsd ikpehlgtca lfeemqigse 361 rynlfqgcpq aktctlllrg gaeqviaeve rslhdaimiv kralqnkliv agggatemev 421 skclrdyskt iagkqqmiin afakalevip rqlcenagfd aieilnklrl ahskgekwyg 481 vvfetenigd nfakfvwepa lvkinalnsa teatnlilsv detitnkgse sanagmmppq 541 gagrgrgmpm // LOCUS NP_012425 551 aa linear PLN 30-JUN-2025 DEFINITION Gzf3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012425 VERSION NP_012425.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181543.1 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 551) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08690. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..551 /product="Gzf3p" /calculated_mol_wt="60389" Region 4..551 /region_name="GAT1" /note="GATA Zn-finger-containing transcription factor [Transcription]; COG5641" /db_xref="CDD:227928" CDS 1..551 /gene="GZF3" /locus_tag="YJL110C" /gene_synonym="DEH1; NIL2" /coded_by="NM_001181543.1:1..1656" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:19380492]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19380492]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:9171383]" /experiment="EXISTENCE:genetic interaction:GO:0090295 nitrogen catabolite repression of transcription [PMID:9106207]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9171383]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:19380492]" /experiment="EXISTENCE:mutant phenotype:GO:0090295 nitrogen catabolite repression of transcription [PMID:9171383|PMID:9171427]" /experiment="EXISTENCE:physical interaction:GO:0051457 maintenance of protein location in nucleus [PMID:19380492]" /note="GATA zinc finger protein; negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p; GZF3 has a paralog, DAL80, that arose from the whole genome duplication" /db_xref="GeneID:853334" /db_xref="SGD:S000003646" ORIGIN 1 masqattlrg ynirkrdnvf epkssenlns lnqseeeghi grwpplgyea vsaeqksavq 61 lresqagasi snnmnfkand ksfststagr mspdtnslhh ilpknqvknn gqtmdancnn 121 nvsndanvpv ckncltsttp lwrrdehgam lcnacglflk lhgkprpisl ktdviksrnr 181 ksntnhahnl dnfrnqtlia elkgdcnies sgrkanrvts edkkkkssql lmgtsstaki 241 skkpkteske rsdshlsatk levlmsgdcs rpnlkpklpk qdtaiyqekl ltfpsytdvk 301 eysnsahqsa fikersqfna asfplnashs vtsktgadsp qlphlsmllg slsstsisnn 361 gseivsncnn giastaatla ptssrttdsn psevpnqirs tmsspdiisa krndpaplsf 421 hmasindmle trdraisnvk tettpphfip flqsskapci skansqsisn svsssdvsgr 481 kfenhpakdl gdqlstklhk eeeiiklktr inelelvtdl yrrhineldg kcraleerlq 541 rtvkqegnkg g // LOCUS NP_012426 1769 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-binding rRNA-processing protein UTP10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012426 VERSION NP_012426.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181542.1 REFERENCE 1 (residues 1 to 1769) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1769) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1769) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1769) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08691. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1769 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1769 /product="snoRNA-binding rRNA-processing protein UTP10" /calculated_mol_wt="199951" Region 230..355 /region_name="U3snoRNP10" /note="U3 small nucleolar RNA-associated protein 10; pfam12397" /db_xref="CDD:463559" Region 1490..1637 /region_name="BP28CT" /note="BP28CT (NUC211) domain; smart01036" /db_xref="CDD:214987" CDS 1..1769 /gene="UTP10" /locus_tag="YJL109C" /coded_by="NM_001181542.1:1..5310" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922|PMID:12150911|PMID:12068309|PMID:17652137]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:17652137|PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:17652137]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:15489292]" /experiment="EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17652137]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17652137]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17652137]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]" /note="Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance" /db_xref="GeneID:853335" /db_xref="SGD:S000003645" ORIGIN 1 msslsdqlaq vasnnatval drkrrqklhs asliynskta atqdydfife naskaleels 61 qiepkfaifs rtlfsessis ldrnvqtkee ikdldnaina ylllasskwy laptlhatew 121 lvrrfqihvk ntemlllstl nyyqtpvfkr ilsiiklppl fnclsnfvrs ekpptaltmi 181 klfndmdflk lytsyldqci khnatytnql lfttccfinv vafnsnndek lnqlvpille 241 isakllasks kdcqiaahti lvvfatalpl kktiilaame tilsnldake akhsalltic 301 klfqtlkgqg nvdqlpskif klfdskfdtv siltfldked kpvcdkfits ytrsiarydr 361 sklniilsll kkirleryev rliitdliyl seiledksql velfeyfisi nedlvlkclk 421 slgltgelfe irlttslftn advntdivkq lsdpvettkk dtasfqtfld khselinttn 481 vsmltetger ykkvlslfte aigkgykass fltsffttle sritfllrvt ispaaptalk 541 lislnniaky insiekevni ftlvpclica lrdasikvrt gvkkilslia krpstkhyfl 601 sdklygenvt ipmlnpkdse awlsgflney vtenydisri ltpkrnekvf lmfwanqall 661 ipspyaktvl ldnlnkspty assysslfee fishylenrs sweksciank tnfehfersl 721 vnlvspkekq sfmidfvlsa lnsdyeqlan iaaerlisif aslnnaqklk ivqnivdsss 781 nvessydtvg vlqslpldsd ifvsilnqns isnemdqtdf skrrrrrsst sknaflkeev 841 sqlaelhlrk ltiilealdk vrnvgsekll ftllsllsdl etldqdgglp vlyaqetlis 901 ctlntitylk ehgcteltnv radilvsair nsaspqvqnk lllvigslat lssevilhsv 961 mpiftfmgah sirqddeftt kvvertiltv vpaliknskg nekeemefll lsfttalqhv 1021 prhrrvklfs tliktldpvk algsflflia qqyssalvnf kigearilie fikallvdlh 1081 vneelsglnd lldiikllts sksssekkks lesrvlfsng vlnfsesefl tfmnntfefi 1141 nkiteetdqd yydvrrnlrl kvysvlldet sdkklirnir eefgtllegv lffinsvelt 1201 fscitsqene easdsetsls dhtteikeil fkvlgnvlqi lpvdefvnav lpllststne 1261 diryhltlvi gskfelegse aipivnnvmk vlldrmples ksvvisqvil ntmtalvsky 1321 gkklegsilt qaltlatekv ssdmtevkis slalitncvq vlgvksiafy pkivppsikl 1381 fdasladssn plkeqlqvai lllfaglikr ipsflmsnil dvlhviyfsr evdssirlsv 1441 isliienidl kevlkvlfri wsteiatsnd tvavslflst lestvenidk ksatsqspif 1501 fklllslfef rsissfdnnt isrieasvhe isnsyvlkmn dkvfrplfvi lvrwafdgeg 1561 vtnagitete rllaffkffn klqenlrgii tsyftyllep vdmllkrfis kdmenvnlrr 1621 lvinsltssl kfdrdeywks tsrfelisvs lvnqlsnien sigkylvkai galasnnsgv 1681 dehnqilnkl ivehmkascs sneklwaira mkliyskige swlvllpqlv pviaelledd 1741 deeierevrt glvkvvenvl gepfdryld // LOCUS NP_012427 383 aa linear PLN 30-JUN-2025 DEFINITION pheromone-regulated protein PRM10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012427 VERSION NP_012427.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181541.1 REFERENCE 1 (residues 1 to 383) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 383) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 383) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 383) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08692. Method: conceptual translation. FEATURES Location/Qualifiers source 1..383 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..383 /product="pheromone-regulated protein PRM10" /calculated_mol_wt="41358" Region 1..201 /region_name="ThrE" /note="Putative threonine/serine exporter; pfam06738" /db_xref="CDD:461997" Region 217..377 /region_name="ThrE" /note="Putative threonine/serine exporter; cl46398" /db_xref="CDD:480738" CDS 1..383 /gene="PRM10" /locus_tag="YJL108C" /coded_by="NM_001181541.1:1..1152" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Pheromone-regulated protein; proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation" /db_xref="GeneID:853336" /db_xref="SGD:S000003644" ORIGIN 1 mivsfgdatt rtsevqlvrc tqglnlwklh qvhavykrvv hdtlgadegn alldqiladt 61 nlyppwmcvl lyafcsamvt pyafggdwvn laisffmglc vgslqfilsq ksymysnvfe 121 isasivvsfc grafgsiprs hicfgavtqg slalilpgyi ilcgalelqs rslvagavrm 181 fyaiiyslfl gfgitlgsal fgwmyhnatn eiscpqlisp wfrflfvpaf tisisllnqa 241 hisqlpvmvf isctgyvvty wagkhfanst eftaalaafv igvlgnlysr iwkglavsam 301 lpaifvqvps giasqnslls glqsantivn anetittsts dpsssmsfgm tmiqvcvgis 361 vglfasslfv ypfgkkktgl fsl // LOCUS NP_012428 387 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL107C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012428 VERSION NP_012428.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181540.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 387) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08693. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..387 /product="uncharacterized protein" /calculated_mol_wt="42377" Region 345..>378 /region_name="ThrE" /note="Putative threonine/serine exporter; cl46398" /db_xref="CDD:480738" CDS 1..387 /locus_tag="YJL107C" /coded_by="NM_001181540.1:1..1164" /note="hypothetical protein; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi" /db_xref="GeneID:853337" /db_xref="SGD:S000003643" ORIGIN 1 mdgrnekptt pvsdfrvgss eqsqagvnle dssdhrtsns aeskkgnlsg ksisdlgisn 61 ndnknvrfta dtdalendls srstetsdns kgtdgqdeed rparhkrkpk vsfthlrnng 121 kdgddetfik kiinnltgnq gglvpglapi psenengknd ieknnrneei plsdladask 181 ivdvhegddk eklealkleg dvnctsdget lgsssknsfl apavdhfddy aennssddne 241 gfietstyvp ppsqvksgvl gsllklyqne dqnsssifsd sqavttddeg isstagnkdv 301 pvakrsrlqn lkgkakkgrm prlkkrlkte akitvhiadi lqrhrfilrm cralmmygap 361 thrleeymvm tsrvleidgq fcifqvv // LOCUS NP_012429 645 aa linear PLN 30-JUN-2025 DEFINITION protein kinase IME2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012429 VERSION NP_012429.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181539.1 REFERENCE 1 (residues 1 to 645) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 645) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 645) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 645) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08694. Method: conceptual translation. FEATURES Location/Qualifiers source 1..645 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..645 /product="protein kinase IME2" /EC_number="2.7.11.1" /calculated_mol_wt="73462" Region 38..386 /region_name="STKc_MAK_like" /note="Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; cd07830" /db_xref="CDD:270824" Site order(44..47,52,95,97,113,128,146..149,152,154..155,193, 195,197..198,200,228,231,242,244..247,249,287) /site_type="active" /db_xref="CDD:270824" Site order(44..48,52,95,97,128,146..149,152,193,195,197..198, 200,228) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270824" Site order(113,154,193,195,231,242,244..247,249,287) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270824" Site order(227..237,240..249) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270824" CDS 1..645 /gene="IME2" /locus_tag="YJL106W" /gene_synonym="SME1" /coded_by="NM_001181539.1:1..1938" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:7764269|PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7764269]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:9003314]" /note="Serine/threonine protein kinase involved in activation of meiosis; associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p; human CDK2 can complement ime2 null mutant" /db_xref="GeneID:853338" /db_xref="SGD:S000003642" ORIGIN 1 mvekrsrqss ssgsefsvpp dvdnpplsip lktlsdryql ieklgagsfg cvtlakaqfp 61 lsnilgkqhd irgtlmdqpk nghqnyitkt qgvvaiktmm tklhtlqdyt rvreikfila 121 ipandhliqi fevfidseny qlhivmecme qnlyqmmkhr rrrvfsipsl ksilsqilag 181 lkhihehnff hrdlkpenil itpstqyfek eymnqigyqd nyvikladfg larhvenknp 241 ytayvstrwy rspeillrsg yyskpldiwa fgcvavevtv fralfpgane idqiwkilev 301 lgtpikrsdf vntnhitapp pggfwddasn lvhklnlklp yvegssldhl lsssqlsdls 361 evvkkclrwd pnerataqel cempffentv asqvdargnv tnteqalifa ginpvatntk 421 piyfnsstkl paetesndid isnndhdsha mcsptlnqek ltlveflnef veednddhsi 481 pdvgtdstis dsidetelsk eirnnlalcq lpdeevldhs lsnirqltnd ieiinkdead 541 nmeqlffdle ipekdefqrk qpfnehadid edivlpyvnn snythtdrsh hrgdnvlgda 601 slgdsfnsmp dftprnflip tlkksrekfe phlsnsnqhf gnvtf // LOCUS NP_012430 560 aa linear PLN 30-JUN-2025 DEFINITION Set4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012430 VERSION NP_012430.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181538.1 REFERENCE 1 (residues 1 to 560) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 560) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 560) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 560) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08695. Method: conceptual translation. FEATURES Location/Qualifiers source 1..560 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..560 /product="Set4p" /calculated_mol_wt="63725" Region 163..207 /region_name="PHD_SF" /note="PHD finger superfamily; cl22851" /db_xref="CDD:473978" Site order(175..178,182,202) /site_type="other" /note="histone H3 binding site [polypeptide binding]" /db_xref="CDD:276966" Region 346..527 /region_name="SET_SpSET3-like" /note="SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; cd19183" /db_xref="CDD:380960" Site order(358..359,376,386,400..407,424..428,436,461,472..478) /site_type="active" /note="putative active site [active]" /db_xref="CDD:380960" Site order(358..359,400..403,424..428,474) /site_type="other" /note="putative SAM binding site" /db_xref="CDD:380960" CDS 1..560 /gene="SET4" /locus_tag="YJL105W" /coded_by="NM_001181538.1:1..1683" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:34625508]" /experiment="EXISTENCE:mutant phenotype:GO:1900407 regulation of cellular response to oxidative stress [PMID:30082318]" /note="Chromatin-associated protein involved in control of stress response; regulates response to oxidative stress; involved in control of gene repression in subtelomeric chromatin; contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication" /db_xref="GeneID:853339" /db_xref="SGD:S000003641" ORIGIN 1 mtspeslssr hirqgrtytt tdkvisrsss yssnssmskd ygdhtplsvs saasetlpsp 61 qympirtfnt mptagptplh lfqndrgifn hhsssgsskt astnkrgiaa avalataati 121 pfplkkqnqd dnskvsvthn esskenkitp smraednkpk ngcicgssds kdelfiqcnk 181 cktwqhklcy afkksdpikr dfvckrcdsd tkvqvnqvkp mifprkmgde rlfqfssivt 241 tsasntnqhq qsvnnieeqp kkrqlhytap ttensnsirk klrqeklvvs shflkpllne 301 vsssndtefk aitiseykdk yvkmfidnhy dddwvvcsnw essrsadiev rkssnerdfg 361 vfaadscvkg eliqeylgki dfqknyqtdp nndyrlmgtt kpkvlfhphw plyidsretg 421 gltryirrsc epnvelvtvr pldekprgdn dcrvkfvlra irdirkgeei svewqwdlrn 481 piweiinask dldslpdpdk fwlmgsikti ltncdcacgy lghncpitki knfseefmrn 541 tkeslsnksy fntimhnckp // LOCUS NP_012431 149 aa linear PLN 30-JUN-2025 DEFINITION import motor complex subunit PAM16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012431 VERSION NP_012431.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181537.1 REFERENCE 1 (residues 1 to 149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 149) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08696. Method: conceptual translation. FEATURES Location/Qualifiers source 1..149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..149 /product="import motor complex subunit PAM16" /calculated_mol_wt="16085" Region 1..128 /region_name="Pam16" /note="pfam03656" /db_xref="CDD:252088" CDS 1..149 /gene="PAM16" /locus_tag="YJL104W" /gene_synonym="MIA1; TIM16" /coded_by="NM_001181537.1:1..450" /experiment="EXISTENCE:direct assay:GO:0001405 PAM complex, Tim23 associated import motor [PMID:14981507|PMID:14981506]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:14981506]" /experiment="EXISTENCE:direct assay:GO:0019904 protein domain specific binding [PMID:16105940]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:14981506|PMID:14981507]" /note="Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain" /db_xref="GeneID:853340" /db_xref="SGD:S000003640" ORIGIN 1 mahrafiqvi itgtqvfgka faeayrqaas qsvkqgatna srrgtgkgey ggitldesck 61 ilnieeskgd lnmdkinnrf nylfevndke kggsfylqsk vyraaerlkw elaqreknak 121 akagdastak pppnstnssg adnsassnq // LOCUS NP_012432 618 aa linear PLN 30-JUN-2025 DEFINITION Gsm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012432 VERSION NP_012432.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181536.1 REFERENCE 1 (residues 1 to 618) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 618) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 618) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 618) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08697. Method: conceptual translation. FEATURES Location/Qualifiers source 1..618 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..618 /product="Gsm1p" /calculated_mol_wt="70251" Region 14..>44 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(19,24..27,29,32,41) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(20,23,30,36,39) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..618 /gene="GSM1" /locus_tag="YJL103C" /coded_by="NM_001181536.1:1..1857" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:16785442]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:16785442]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16785442]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:16785442]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:16785442]" /note="Putative zinc cluster hypothetical protein; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis" /db_xref="GeneID:853341" /db_xref="SGD:S000003639" ORIGIN 1 mtkklpselk qtrksiqtac efchtkhiqc dvgrpcqncl krnigkfcrd kkrksrkrie 61 khgtqpylnl gkrlvihdvp sktvspssvh lqrdflssdq ekpgktpahn tniqytynin 121 dnfqsagsip ritnfntnnr qtvlentsnn isasqavhlm ndpiiptvrk stlnlkshfl 181 eqhkamqqpl atnclvatsn vpvhsgmdds nksdddvdde tnihfdsmwc ndeymklkdi 241 vdistpflpn nsqifslqes eypnpsastr gnsslhltnl lnstksvndq kdssighsts 301 tfntydevvs rpfisldmlh lnrgananth pshnaklese cdssshsdad lekhdtdfis 361 pskfrelvkt pqdlydnkcl ikphnyklay tkllttlrkk flegaeidks asvkdehstq 421 khnlrydlev iirsilerya pifisltsnm ieedlllqev tlqralldle nmaklvsctp 481 mciwrrsgei cfvsnefysl tgfnknllld rtsfifeyld hksvsnyfqi fnellafgyn 541 dinkrkkllm lnacsstssk itegfsfttd gkaiftkcnl llsnglylkc accwtvkrds 601 fnipilvmgq flpifemd // LOCUS NP_012433 819 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial elongation factor MEF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012433 VERSION NP_012433.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181535.1 REFERENCE 1 (residues 1 to 819) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 819) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 819) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 819) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 819) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 819) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 819) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08698. Method: conceptual translation. FEATURES Location/Qualifiers source 1..819 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..819 /product="mitochondrial elongation factor MEF2" /calculated_mol_wt="91152" Region 34..816 /region_name="FusA" /note="Translation elongation factor EF-G, a GTPase [Translation, ribosomal structure and biogenesis]; COG0480" /db_xref="CDD:440248" CDS 1..819 /gene="MEF2" /locus_tag="YJL102W" /coded_by="NM_001181535.1:1..2460" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:21414316]" /experiment="EXISTENCE:mutant phenotype:GO:0051881 regulation of mitochondrial membrane potential [PMID:21414316]" /note="Mitochondrial elongation factor involved in translational elongation" /db_xref="GeneID:853342" /db_xref="SGD:S000003638" ORIGIN 1 mwkwnvrrwa garvnisknr lsvinvgsry lstarsplsk vrnigiiahi dagktttter 61 mlyyagiskh igdvdtgdti tdfleqersr gitiqsaais fpwrntfain lidtpghidf 121 tfeviralkv idscvvilda vagveaqtek vwkqskskpk icfinkmdrm gasfnhtvnd 181 linkfmrgtt tkpvlvnipy yrkqptsndy vfqgvidvvn gkrltwnpen pdeiivdeld 241 gtsleqcnrc resmietlte ydedlvqhfl eeaegdyskv saqflnasir kltmknmivp 301 vlcgasfkni gvqplldaiv nylpspieae lpelndktvp mkydpkvgcl vnnnknlcia 361 lafkvitdpi rgkqifiriy sgtlnsgntv ynsttgekfk lgklliphag tsqpvnilta 421 gqiglltgst vennistgdt lithsskkdg lksldkkkel tlkinsifip ppvfgvsiep 481 rtlsnkksme ealntlited pslsisqnde tgqtvlngmg elhleiakdr lvndlkadve 541 fgqlmvsyke tinsetniet yesddgyrfs lsllpnsdal pnclayplgv nenflimekn 601 gnwdkewkyq vsfesilnsi iascivglqr ggkianfply acsikinsdw svppdietpq 661 eilkitrnli fkalndlkpe kynllepimn ldltipqsdv gtvlqdltga rkaqilsied 721 essvsnsgas tcnspensnr iyipsdavtt lhatkdkknt qetssnvkki ikakvplrei 781 ttytnklrsl sqgrgefnie ysdmekvtnd rlqsilhdl // LOCUS NP_012434 678 aa linear PLN 30-JUN-2025 DEFINITION glutamate--cysteine ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012434 VERSION NP_012434.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181534.1 REFERENCE 1 (residues 1 to 678) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 678) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 678) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 678) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08699. Method: conceptual translation. FEATURES Location/Qualifiers source 1..678 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..678 /product="glutamate--cysteine ligase" /EC_number="6.3.2.2" /calculated_mol_wt="78123" Region 253..645 /region_name="GCS" /note="Glutamate-cysteine ligase; pfam03074" /db_xref="CDD:460796" CDS 1..678 /gene="GSH1" /locus_tag="YJL101C" /coded_by="NM_001181534.1:1..2037" /experiment="EXISTENCE:direct assay:GO:0004357 glutamate-cysteine ligase activity [PMID:1687097]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:2184310]" /experiment="EXISTENCE:direct assay:GO:0006750 glutathione biosynthetic process [PMID:1687097]" /experiment="EXISTENCE:direct assay:GO:0046686 response to cadmium ion [PMID:10921921]" /experiment="EXISTENCE:mutant phenotype:GO:0004357 glutamate-cysteine ligase activity [PMID:2184310]" /experiment="EXISTENCE:mutant phenotype:GO:0006750 glutathione biosynthetic process [PMID:8768524]" /experiment="EXISTENCE:mutant phenotype:GO:0042542 response to hydrogen peroxide [PMID:7615092]" /note="Gamma glutamylcysteine synthetase; catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853344" /db_xref="SGD:S000003637" ORIGIN 1 mgllalgtpl qwfesrtyne hirdegieql lyifqaagkr dndplfwgde leymvvdfdd 61 kernsmldvc hdkiltelnm edsslceand vsfhpeygry mleatpaspy lnyvgsyvev 121 nmqkrraiae yklseyarqd sknnlhvgsr svpltltvfp rmgcpdfini kdpwnhknaa 181 srslflpdev inrhvrfpnl tasirtrrge kvcmnvpmyk diatpetdds iydrdwflpe 241 dkeaklaskp gfiymdsmgf gmgcsclqvt fqapninkar ylydalvnfa pimlafsaaa 301 pafkgwladq dvrwnvisga vddrtpkerg vapllpkynk ngfggiakdv qdkvleipks 361 ryssvdlflg gskffnrtyn dtnvpinekv lgrllendka pldydlakhf ahlyirdpvs 421 tfeellnqdn ktssnhfeni qstnwqtlrf kpptqqatpd kkdspgwrve frpfevqlld 481 fenaaysvli ylivdsiltf sdninayihm skvwenmkia hhrdailfek fhwkksfrnd 541 tdvetedysi seifhnpeng ifpqfvtpil cqkgfvtkdw kelkhsskhe rlyyylklis 601 drasgelptt akffrnfvlq hpdykhdski sksinydlls tcdrlthldd skgeltsflg 661 aeiaeyvkkn kpsieskc // LOCUS NP_012435 607 aa linear PLN 30-JUN-2025 DEFINITION 1-phosphatidylinositol 4-kinase LSB6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012435 VERSION NP_012435.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181533.1 REFERENCE 1 (residues 1 to 607) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 607) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 607) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 607) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08700. Method: conceptual translation. FEATURES Location/Qualifiers source 1..607 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..607 /product="1-phosphatidylinositol 4-kinase LSB6" /EC_number="2.7.1.67" /calculated_mol_wt="70086" Region 170..498 /region_name="PI3_PI4_kinase" /note="Phosphatidylinositol 3- and 4-kinase; pfam00454" /db_xref="CDD:395364" CDS 1..607 /gene="LSB6" /locus_tag="YJL100W" /coded_by="NM_001181533.1:1..1824" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12523934|PMID:26928762|PMID:12361950]" /experiment="EXISTENCE:direct assay:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:12361950|PMID:12523934]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12523934|PMID:12361950]" /experiment="EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:12361950|PMID:12523934]" /experiment="EXISTENCE:mutant phenotype:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:12361950]" /experiment="EXISTENCE:mutant phenotype:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:12361950]" /note="Type II phosphatidylinositol 4-kinase; binds Las17p, a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization" /db_xref="GeneID:853345" /db_xref="SGD:S000003636" ORIGIN 1 msneayqhdh tvnphqkivv nsydwlqfrd eqdhcksknp ithaspgvgs naqnsdiaea 61 pqvfhpsyqs lvnvpsespr pdqtsgsnpa vgllhnaedk asgqeeegsq yeiqysvfrp 121 lhayptkgla yeqlrrkeeq eqrenfnhlv sdcieavetf greleriqtg ssgsyfvygt 181 radesvpvgv fkpkdeepyg pfspkwtkwa hrtffpclfg rsclipnlgy icesaaslld 241 rrlethlvpy tdtasiesfn fydnrkkwvl gynlqkkkqk klgsfqlflk eyinadeffh 301 kyplpgmysd vkhsfhrkss gedinhkpet trnltdetep skqinsspis teseenskfe 361 wtesslsqfr lelekliild yimrntdrgl dnwmvklikl snnkwrlkla aidnglsfpw 421 khpdewrlyp ygwlylplql lakpfseqmr shflpiltst nwweesyqef lalfsrdqdf 481 nvrmwkkqwa vlkgqafnvv etlkdprqgp lelvrrtrcq videkmqvpc cpppvsifkn 541 aidepigsys tspmvlpstp stipfhahnq snsnpvyyds tlhpfanktv iaerlqivns 601 tpvftwc // LOCUS NP_012436 746 aa linear PLN 30-JUN-2025 DEFINITION Chs6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012436 VERSION NP_012436.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181532.1 REFERENCE 1 (residues 1 to 746) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 746) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 746) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 746) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08701. Method: conceptual translation. FEATURES Location/Qualifiers source 1..746 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..746 /product="Chs6p" /calculated_mol_wt="85912" Region 89..558 /region_name="ChAPs" /note="ChAPs (Chs5p-Arf1p-binding proteins); pfam09295" /db_xref="CDD:401292" CDS 1..746 /gene="CHS6" /locus_tag="YJL099W" /gene_synonym="CSD3" /coded_by="NM_001181532.1:1..2241" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030140 trans-Golgi network transport vesicle [PMID:16498409]" /experiment="EXISTENCE:direct assay:GO:0034044 exomer complex [PMID:23000721|PMID:17000877]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:9614194]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:11879634|PMID:9614194]" /note="Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; primary component of the Chs5/6 complex that binds directly to membranes; CHS6 has a paralog, BCH2, that arose from the whole genome duplication" /db_xref="GeneID:853346" /db_xref="SGD:S000003635" ORIGIN 1 mnlfwpsetk kqneipggdy tpgnspsvqk gyqflnrdif kscprimerq fgeclhnrth 61 likdlissgn vglgpieivh msylnkheke efgeyfyvtg ievsgpampv eflevlkssk 121 risknisnni iltyccfnff snldiriryd addtfqttai dcnkettdlt mtekmweetf 181 assviraiit ntnpelkppg lvecpfyvgk dtissckkii ellcrflprs lncgwdstks 241 mqativnnyl myslksfiai tpslvdftid ylkgltkkdp ihdiyyktam itildhietk 301 eldmitilne tldpllslln dlpprdadsa rlmncmsdll niqtnfllnr gdyelalgvs 361 ntstelalds feswynlarc hikkeeyeka lfainsmprl rkndghletm ysrfltsnyy 421 kkplngtreh ydltameftn lsgtlrnwke delkrqifgr iaminekkig ytkeiwddia 481 iklgpicgpq svnlinyvsp qevkniknin liarntigkq lgwfsgkiyg llmeivnkig 541 wngllnirte afmmetefyq asnniideng hipmesrkkr fcegwlddlf ldlyqdlkls 601 kislsnkdek hsglewellg limlrtwhwe davaclrtsi varfdpvscq qllkiylqpp 661 kniqevtlld tdtiisllik kisydcryyn ycqifnlqll eklcnelgth ilrnkillqp 721 sigdeimvmi damlawiadl dhtvqp // LOCUS NP_012437 1058 aa linear PLN 30-JUN-2025 DEFINITION Sap185p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012437 VERSION NP_012437.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181531.1 REFERENCE 1 (residues 1 to 1058) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1058) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1058) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1058) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1058) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1058) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1058) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08702. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1058 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1058 /product="Sap185p" /calculated_mol_wt="121272" Region 259..772 /region_name="SAPS" /note="SIT4 phosphatase-associated protein; pfam04499" /db_xref="CDD:398279" CDS 1..1058 /gene="SAP185" /locus_tag="YJL098W" /coded_by="NM_001181531.1:1..3177" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:1903766 positive regulation of potassium ion export across plasma membrane [PMID:15947196]" /experiment="EXISTENCE:genetic interaction:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8649382]" /experiment="EXISTENCE:mutant phenotype:GO:1903766 positive regulation of potassium ion export across plasma membrane [PMID:15947196]" /note="Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p; SAP185 has a paralog, SAP190, that arose from the whole genome duplication" /db_xref="GeneID:853347" /db_xref="SGD:S000003634" ORIGIN 1 msgsfwkfgq dfgsqsplak llnrafikid dkptsteagk idsnstdesl esnsfksede 61 eeeyelpnre edykaykpnl sllndlldde elytelmcsn fkllvylkyp evlsklidyv 121 rnstilesni drvtsedrdl vrgedkdtte dfenakadkk nidgtfeeke rtrsgeeeel 181 eneendsase dtrvtlphel eehddtrrar iaaeilsadv wpissalien egllaklwsi 241 lrlpsplsie astyfmkine rlldmnmdgi iefilkkehi vddflahidn pplmdfllkv 301 istdkpeisn gviqlfkkqn lvpklihlld pvfdsctqsa agdflkalvt isgncpneit 361 ssigpneltr qlvspnmmkq lmdimlkggn slnngvgiii elirknnsdy dtiqtnytti 421 eshpptdrdp iylgylvkmf sehmadfnki ltekkipllq tsygtieplg ferfkiceli 481 aellhcsnmt llnepsaydi vrerdaerer ifnsqnyvds ndrselkene ddntgdadde 541 veddtnqves antsidgeev idklnslqie tnkvnqnmnn eeqhslmpdf nngdfkdeed 601 enpfepqysd vildssdiek nfrvspnvgd qlkislqdtr vidtmlemff hfqwnnflhn 661 vvydvvqqif ngplkigynr fllddllini rltdmiingn necieyekgh dtrlgymghl 721 tliaeevtkf tayieemnit fentevmssl feskwiayte dvledlkeky nailgdiaee 781 gdmlqdeeed avydkgertm gtvddyindi mqmdnvrcqe eeedegegyv sfdedepqey 841 rngdsvrske snssegkrdq eqlyyeyvne dgtktrlnfn pdsdateqvp gevnrdhkip 901 lklkrsftda cksetipnnt vnakeesvfq fsnelsdgwe sspsnsipkr aspskngmns 961 pmfqhqfelh sptdefgghk deilsaeghd ydideydels ddsdeeydnc ededsldyad 1021 saayalcrsk skdkiswdee eqarlmgvvk fnsehyrd // LOCUS NP_012438 217 aa linear PLN 30-JUN-2025 DEFINITION enoyl-CoA hydratase PHS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012438 VERSION NP_012438.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181530.1 REFERENCE 1 (residues 1 to 217) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 217) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 217) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 217) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08703. Method: conceptual translation. FEATURES Location/Qualifiers source 1..217 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..217 /product="enoyl-CoA hydratase PHS1" /EC_number="4.2.1.134" /calculated_mol_wt="24380" Region 1..217 /region_name="Ptpl" /note="Protein tyrosine phosphatase-like protein (contains Pro instead of catalytic Arg) [General function prediction only]; COG5198" /db_xref="CDD:227525" CDS 1..217 /gene="PHS1" /locus_tag="YJL097W" /coded_by="NM_001181530.1:1..654" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:23708375|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0004300 enoyl-CoA hydratase activity [PMID:18272525]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:18272525]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:14690591]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:16943325]" /experiment="EXISTENCE:mutant phenotype:GO:0018812 3-hydroxyacyl-CoA dehydratase activity [PMID:23416297]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:18272525]" /experiment="EXISTENCE:mutant phenotype:GO:0030497 fatty acid elongation [PMID:23416297]" /note="Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane; involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking" /db_xref="GeneID:853348" /db_xref="SGD:S000003633" ORIGIN 1 mskklaspls flplynllsa vgwsyllylv islypkvgqp affyqtknva tlvqcgaiie 61 iinsflgvvr spllttvaqv ssrllvvlgi fqllpntsgv qsvvyislll awsiteivry 121 lyyffmlvfk ngapkilill rynlfwilyp tgvaselrii ycalnaaesq ysllykrili 181 aamlayipgf pmlflhmvaq rkkvmkslrs sfgkkli // LOCUS NP_012439 161 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL21m MRPL49 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012439 VERSION NP_012439.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181529.1 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 161) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08704. On Oct 2, 2003 this sequence version replaced NP_012439.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..161 /product="mitochondrial 54S ribosomal protein bL21m MRPL49" /calculated_mol_wt="18256" Region 56..157 /region_name="Ribosomal_L21p" /note="Ribosomal prokaryotic L21 protein; pfam00829" /db_xref="CDD:459952" CDS 1..161 /gene="MRPL49" /locus_tag="YJL096W" /gene_synonym="bL21m" /coded_by="NM_001181529.1:1..486" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:853349" /db_xref="SGD:S000003632" ORIGIN 1 mlqlkfiwpv aritpiyrpf tshpfrnlat sssisstkak ttktdttplk lsnelyaifk 61 ihnrpylvte gdrvilpfkl kqaevgdiln mtdvttlgsr nyklvghpin tslytlkatv 121 vgktkrafqt revtkrrnrr vrhakskgdl tilriselsm n // LOCUS NP_012440 1478 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase kinase kinase BCK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012440 VERSION NP_012440.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181528.1 REFERENCE 1 (residues 1 to 1478) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1478) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1478) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08705. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1478 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1478 /product="mitogen-activated protein kinase kinase kinase BCK1" /EC_number="2.7.11.1" /calculated_mol_wt="164065" Region 1173..1440 /region_name="STKc_Bck1_like" /note="Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases; cd06629" /db_xref="CDD:270799" Site order(1181..1185,1189,1202,1204,1241,1257..1260,1263..1264, 1267,1303,1305..1308,1310,1320..1321,1324,1339..1342,1344, 1372,1381) /site_type="active" /db_xref="CDD:270799" Site order(1181..1185,1189,1202,1204,1241,1257..1260,1262..1264, 1267,1307..1308,1310,1320..1322) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270799" Site order(1184..1185,1303,1305..1307,1324,1339..1342,1344,1372, 1381) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270799" Site order(1320..1334,1336..1344) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270799" CDS 1..1478 /gene="BCK1" /locus_tag="YJL095W" /gene_synonym="LAS3; SAP3; SLK1; SSP31" /coded_by="NM_001181528.1:1..4437" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:8386320|PMID:1729597]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:1729597]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20385774]" /experiment="EXISTENCE:mutant phenotype:GO:0004709 MAP kinase kinase kinase activity [PMID:11283616]" /experiment="EXISTENCE:mutant phenotype:GO:0010447 response to acidic pH [PMID:16087742]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:1545797]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:16380504]" /experiment="EXISTENCE:mutant phenotype:GO:0035556 intracellular signal transduction [PMID:8190082]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:1729597]" /note="MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase" /db_xref="GeneID:853350" /db_xref="SGD:S000003631" ORIGIN 1 mpflrkiagt ahthsrsdsn ssvkfghqpt ssvastksss kspratsrks iyddirsqfp 61 nltpnstssq fyestpvieq sfnwttddhi sagtlenpts ftnssykndn gpsslsdsrk 121 ssggnsvnsl sfdklilswd ptdpdewtmh rvtswfkfhd fpeswilffk khqlfghrfi 181 kllaydnfav yekylpqtkt asytrfqqll kktmtknvtn shirqksask lkssrssses 241 iksklknsks qedisnsrst sesalsptks gpsktdeknf lhststhqkt ksasslyrrs 301 fislrgssss nassakspsn iklsiparph siiesnstlt ksasppasps ypsifrrhhk 361 ssssesslln slfgsgigee aptkpnpqgh slssenlakg kskhyetnvs splkqsslpt 421 sddkgnlwnk fkrksqigvp spntvayvts qetpslksns statltvqta dvnipspsss 481 pppipktanr slevistedt pkissttasf ketypdcinp dktvpvpvnn qkysvknfll 541 dqkfyplkkt glndsenkyi lvtkdnvsfv plnlksvakl ssfkesaltk lginhknvtf 601 hmtdfdcdig aaipddtlef lkkslflnts gkiyikdqmk lqqkpkpapl tsennvplks 661 vkskssmrsg tssliastdd vsivtsssdi tsfdehasgs grrypqtpsy yydrvsntnp 721 teelnywnik evlsheenap kmvfktspkl elnlpdkgsk lniptpiten eskssfqvlr 781 kdegteidfn hrrespytkp elapkreapk ppantspqrt lstskqnkpi rlvrastkis 841 rskrskplpp qllsspieas ssspdsltss ytpasthvli pqpykgandv mrrlktdqds 901 tstspslkmk qkvnrsnstv stsnsifysp spllkrgnsk rvvsstsaad ifeenditfa 961 dappmfdsdd sdddssssdd iiwskkktap etnnenkkde ksdnssthsd eifydsqtqd 1021 kmerkmtfrp spevvyqnle kffpranldk pitegiaspt spksldslls pknvassrte 1081 pstpsrpvpp dssyefiqdg lngknkplnq aktpkrtkti rtiaheasla rknsvklkrq 1141 ntkmwgtrmv evtenhmvsi nkaknskgey kefawmkgem igkgsfgavy lclnvttgem 1201 mavkqvevpk yssqneails tvealrsevs tlkdldhlni vqylgfenkn niyslfleyv 1261 aggsvgslir mygrfdepli khlttqvlkg laylhskgil hrdmkadnll ldqdgickis 1321 dfgisrkskd iysnsdmtmr gtvfwmapem vdtkqgysak vdiwslgciv lemfagkrpw 1381 snlevvaamf kigksksapp ipedtlplis qigrnfldac feinpekrpt anellshpfs 1441 evnetfnfks trlakfiksn dklnssklri tsqenkte // LOCUS NP_012441 873 aa linear PLN 30-JUN-2025 DEFINITION Kha1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012441 VERSION NP_012441.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181527.1 REFERENCE 1 (residues 1 to 873) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 873) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 873) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 873) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 873) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 873) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 873) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08706. Method: conceptual translation. FEATURES Location/Qualifiers source 1..873 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..873 /product="Kha1p" /calculated_mol_wt="96980" Region 1..>433 /region_name="PLN03159" /note="cation/H(+) antiporter 15; Provisional" /db_xref="CDD:215608" CDS 1..873 /gene="KHA1" /locus_tag="YJL094C" /coded_by="NM_001181527.1:1..2622" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15926887]" /experiment="EXISTENCE:mutant phenotype:GO:0015386 potassium:proton antiporter activity [PMID:9811642]" /experiment="EXISTENCE:mutant phenotype:GO:0098662 inorganic cation transmembrane transport [PMID:9811642]" /note="Putative K+/H+ antiporter; involved in intracellular cation homeostasis; promotes copper binding to Fet3p multicopper oxidase; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:853351" /db_xref="SGD:S000003630" ORIGIN 1 mantvggils gvnpfhynss spltlflfqa clillvcnli hipfsmmrqp kvisevisgv 61 ilgptifgqi pnytntifpt ssipglnlva nlgiilfmff lglevdiafi kkhlkkalvi 121 givtlavpfg fgcllaiplf htyanktege rhikfsvfmv fiavsisvta fpvlcrilne 181 lrlikdragi vvlaagiind imgwillals iilssaegsp vntvyillit fawfliyffp 241 lkyllrwvli rtheldrskp splatmcilf imfisayftd iigvhpifga fiaglvvprd 301 dhyvvklter medipnivfi piyfavagln vdltllnegr dwgyvfatig iaiftkiisg 361 tltakltglf wreataagvl msckgiveiv vltvglnagi isrkifgmfv lmalvstfvt 421 tpltqlvypd syrdgvrksl stpaeddgaa dgldsegvdk teintqlnsl advskyrige 481 lttvinttea ispslkllny lslgvspkpk nnkhknetsl srmttatdst lksntfkikk 541 mvhiwsksvd dvdtnlsvid ekltpfegvg alraihlrll terttdllqs sslynddphf 601 tantdsllqi fdifsnlski pfssevifst mrekaaniat mkmdstdlil lplkgasyey 661 rgspvfidek yanfdhiysh llglnelsst ffksifqslk anfavqisnt ygrlnadrfk 721 rkrfnlllpk pyltqsdylg lyllllicyr dgynndnasc sifinsknid fakdlstafa 781 ehdwlnesti kivdipfetk vpeeaiekps fietvldvgl sdtaladiee ttfiigedlp 841 desepfseev rtvifegsnr rfdtlivhhf sse // LOCUS NP_012442 691 aa linear PLN 30-JUN-2025 DEFINITION Tok1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012442 VERSION NP_012442.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181526.1 REFERENCE 1 (residues 1 to 691) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 691) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 691) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 691) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08707. Method: conceptual translation. FEATURES Location/Qualifiers source 1..691 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..691 /product="Tok1p" /calculated_mol_wt="77277" Region 253..328 /region_name="Ion_trans_2" /note="Ion channel; pfam07885" /db_xref="CDD:462301" Region 388..462 /region_name="Ion_trans_2" /note="Ion channel; pfam07885" /db_xref="CDD:462301" CDS 1..691 /gene="TOK1" /locus_tag="YJL093C" /gene_synonym="DUK1; YKC1; YPK1" /coded_by="NM_001181526.1:1..2076" /experiment="EXISTENCE:direct assay:GO:0005267 potassium channel activity [PMID:7651518]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:7651518]" /experiment="EXISTENCE:direct assay:GO:0030007 intracellular potassium ion homeostasis [PMID:7651518]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005249 voltage-gated potassium channel activity [PMID:16133265]" /experiment="EXISTENCE:mutant phenotype:GO:0005267 potassium channel activity [PMID:7651518]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:7651518]" /experiment="EXISTENCE:mutant phenotype:GO:0030007 intracellular potassium ion homeostasis [PMID:7651518]" /note="Outward-rectifier potassium channel of the plasma membrane; has two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin" /db_xref="GeneID:853352" /db_xref="SGD:S000003629" ORIGIN 1 mtrfmnsfak qtlgygnmat veqessaqav dshsnntpkq akgvlaeelk dalrfrderv 61 siinaepsst lfvfwfvvsc yfpvitaclg pvantisiac vvekwrslkn nsvvtnprsn 121 dtdvlmnqvk tvfdppgifa vniislvlgf tsniilmlhf skkltylksq linitgwtia 181 ggmllvdviv cslndmpsiy sktigfwfac issglylvct iiltihfigy klgkypptfn 241 llpnersima ytvllslwli wgagmfsgll hitygnalyf ctvslltvgl gdilpksvga 301 kimvlifsls gvvlmglivf mtrsiiqkss gpifffhrve kgrskswkhy mdssknlser 361 eafdlmkcir qtasrkqhwf slsvtiaifm afwllgalvf kfaenwsyfn ciyfcflcll 421 tigygdyapr tgagraffvi walgavplmg ailstvgdll fdistsldik igesfnnkvk 481 sivfngrqra lsfmvntgei feesdtadgd leenttssqs sqisefndnn seendsgvts 541 ppaslqesfs slskasspeg ilpleyvssa eyalqdsgtc nlrnlqellk avkklhricl 601 adkdytlsfs dwsyihklhl rnitdieeyt rgpefwispd tplkfplnep hfafmmlfkn 661 ieelvgnlve deelykvisk rkflgehrkt l // LOCUS NP_012443 1174 aa linear PLN 30-JUN-2025 DEFINITION DNA helicase SRS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012443 VERSION NP_012443.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181525.1 REFERENCE 1 (residues 1 to 1174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1174) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08708. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1174 /product="DNA helicase SRS2" /EC_number="5.6.2.4" /calculated_mol_wt="134176" Region 10..750 /region_name="UvrD" /note="Superfamily I DNA or RNA helicase [Replication, recombination and repair]; COG0210" /db_xref="CDD:439980" Region 1107..1174 /region_name="Srs2_C" /note="C-terminal domain of Saccharomyces cerevisiae structural ATP-dependent DNA helicase Srs2 and similar proteins; cd22877" /db_xref="CDD:467854" Site order(1148..1153,1155..1156,1160,1169..1174) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:467854" CDS 1..1174 /gene="SRS2" /locus_tag="YJL092W" /gene_synonym="HPR5" /coded_by="NM_001181525.1:1..3525" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19506039]" /experiment="EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:10908335]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:25765656]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:8419328]" /experiment="EXISTENCE:direct assay:GO:1990986 DNA recombinase disassembly [PMID:12748644|PMID:12748645]" /experiment="EXISTENCE:direct assay:GO:2000042 negative regulation of double-strand break repair via homologous recombination [PMID:19595720]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:7768432]" /experiment="EXISTENCE:mutant phenotype:GO:0007127 meiosis I [PMID:23770697]" /experiment="EXISTENCE:mutant phenotype:GO:0042262 DNA protection [PMID:31168653]" /experiment="EXISTENCE:mutant phenotype:GO:0045910 negative regulation of DNA recombination [PMID:23770697]" /experiment="EXISTENCE:mutant phenotype:GO:1990986 DNA recombinase disassembly [PMID:23770697]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:31142613]" /note="DNA helicase and DNA-dependent ATPase; role in DNA repair and checkpoint recovery, in the proper timing of commitment to meiotic recombination and the Meiosis I to II transition; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; stimulates Mus81p-Mms4p endonuclease activity independent of catalytic activity; ATPase and ssDNA translocating motor activities inhibited by Dmc1p; functional homolog of human RTEL1" /db_xref="GeneID:853353" /db_xref="SGD:S000003628" ORIGIN 1 mssnndlwlh lvsqlntqqr aaalfdytrg lqviagpgtg ktkvltsrva ylilhhhihp 61 rdiivttftn kaanemkerl qemlrgagvn iselligtfh siclkilyrf ghlvdlqkdw 121 riidekeidv ilddmiekvp dqirdyassi trkvnlcmps kngdewtihp klikkqiskl 181 ksnailpeey ildsnhdaal gyfyqiyqse lskkntldfd dllmytfrll trvrvlsnik 241 hvlvdefqdt ngiqldlmfl fakgnhhlsr gmtivgdpdq siyafrnala hnflemgrkc 301 pieystiilv enyrssqkil ntseilitqq nkgrqnrapl raqfdldfpp vymnfpayfl 361 eapslvrell ylkalpnlft fndfailvrq rrqikriesa liehripyki irghsfwdsk 421 etramlnllk lifspndkha ilasllypar glgpatgeki knaldtlatd vscfqilkdi 481 sskkimldip tkgrsviadf ismiencqll lqstllggls dlfdklyels glkyeylykd 541 gkkkndqlek sepnllnarh kniellknyf lallsksess dkekneaika atdeaepien 601 kvitpkeylr nffnslslhs daaeeeeses nkdakikrek ngfvtistih gakglewpvv 661 fipgceegii pcvfnddkkd eseedeeedq enskkdaspk ktrvlsveds ideerrmffv 721 aqtrakylly lsntvtvedv drpriasrfl ttdlikamsd sqklfestns ikklyrilnk 781 kppaeddklf sldqlrkdyn qfienrrerm iwqgiqmndv ygiqlsrnkl lgsvsdftsa 841 adqlrletqn sifpqkklie ksrpskingn yapksrvksp ekryapetts fhsptkkkvy 901 apqyvsttnv psrqefhsst gknipflrre drsitdispr sstrslkgas pnktshmsdd 961 lmrpsptrkd kvtrnihfat agtfrietqs nvdelhppey snksgqslts sefsgfssac 1021 snsdqptnli edinneldls deellndisi errrellgsk ktkkikpktr nrkskrgdkv 1081 kveevidlks efeeddsrnt taaellhnpd dttvdnrpii snakfladaa mkktqkfskk 1141 vknepassqm difsqlsrak kksklnngei ivid // LOCUS NP_012444 490 aa linear PLN 30-JUN-2025 DEFINITION glucosaminyl-phosphotidylinositol O-acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012444 VERSION NP_012444.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181524.1 REFERENCE 1 (residues 1 to 490) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 490) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 490) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 490) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08709. On Oct 2, 2003 this sequence version replaced NP_012444.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..490 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..490 /product="glucosaminyl-phosphotidylinositol O-acyltransferase" /calculated_mol_wt="55335" Region 4..490 /region_name="GWT1" /note="cl02109" /db_xref="CDD:470470" CDS 1..490 /gene="GWT1" /locus_tag="YJL091C" /coded_by="NM_001181524.1:1..1473" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006506 GPI anchor biosynthetic process [PMID:12714589]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:21367863]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:14690591]" /experiment="EXISTENCE:genetic interaction:GO:0032216 glucosaminyl-phosphatidylinositol O-acyltransferase activity [PMID:14517336]" /experiment="EXISTENCE:mutant phenotype:GO:0032216 glucosaminyl-phosphatidylinositol O-acyltransferase activity [PMID:16361252]" /note="Protein involved in the inositol acylation of GlcN-PI; the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) forms glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors" /db_xref="GeneID:853354" /db_xref="SGD:S000003627" ORIGIN 1 mstlkqrked fvtglnggsi teinavtsia lvtyiswnll knsnlmppgi ssvqyiidfa 61 lnwvalllsi tiyasepyll ntlillpcll afiygkftss skpsnpiynk kkmitqrfql 121 ekkpyitayr ggmliltaia ilavdfpifp rrfakvetwg tslmdlgvgs fvfsngivss 181 rallknlslk skpsflknaf nalksggtll flgllrlffv knleyqehvt eygvhwnffi 241 tlsllplvlt fidpvtrmvp rcsiaifisc iyewlllkdd rtlnflilad rncffsanre 301 gifsflgycs iflwgqntgf yllgnkptln nlykpstqdv vaaskksstw dywtsvtpls 361 glciwstifl visqlvfqyh pysvsrrfan lpytlwvity nllfltgycl tdkifgnsse 421 yykvaecles insnglflfl lanvstglvn msmvtidssp lksflvllay csfiavisvf 481 lyrkrifikl // LOCUS NP_012445 764 aa linear PLN 30-JUN-2025 DEFINITION protein kinase activating protein DPB11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012445 VERSION NP_012445.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181523.1 REFERENCE 1 (residues 1 to 764) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 764) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 764) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 764) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08710. Method: conceptual translation. FEATURES Location/Qualifiers source 1..764 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..764 /product="protein kinase activating protein DPB11" /calculated_mol_wt="87110" Region 2..85 /region_name="BRCT" /note="C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; cl00038" /db_xref="CDD:469589" Region 154..221 /region_name="BRCT" /note="C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; cl00038" /db_xref="CDD:469589" Region 326..410 /region_name="BRCT_Rad4_rpt3" /note="third BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; cd18433" /db_xref="CDD:349386" Region 446..>489 /region_name="BRCT" /note="C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; cl00038" /db_xref="CDD:469589" CDS 1..764 /gene="DPB11" /locus_tag="YJL090C" /coded_by="NM_001181523.1:1..2295" /experiment="EXISTENCE:direct assay:GO:0000725 recombinational repair [PMID:16840526]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:10733584]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:18922789]" /experiment="EXISTENCE:direct assay:GO:0070182 DNA polymerase binding [PMID:10733584]" /experiment="EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:16840526]" /experiment="EXISTENCE:genetic interaction:GO:0007095 mitotic G2 DNA damage checkpoint signaling [PMID:18541674]" /experiment="EXISTENCE:mutant phenotype:GO:0000076 DNA replication checkpoint signaling [PMID:10097122]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:10733584|PMID:23629628]" /experiment="EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:21130053]" /experiment="EXISTENCE:mutant phenotype:GO:0031261 DNA replication preinitiation complex [PMID:17167415]" /note="DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:853355" /db_xref="SGD:S000003626" ORIGIN 1 mkpfqgitfc ptainneila kkiskkiikl ggifskdltr qvnvlvvgst tntnkfkfav 61 khrfdiifid iqaiddiyql wlsgenilpd sntatmtgst yemlkilyrr fsfkylhnfn 121 ifigritdtn itsidslvrs ikklgcssyn yqnfvikdts shnddddqgq ngqisifvtd 181 tllgarvnaa ieqnipivhf kwildcqkrs allpydpyyl lpnikdlpyd sigsnscdcw 241 dkinttfptn idaqsslqrq qssstltpsl pktssllnkf kpkgekiwdk amslqqhskt 301 nfsvlgqspl sinnkqedls dnstlifknc afiihhifpg nhrsiltkiv vqnggkiets 361 ylsgiydhsy yiipsnkald sfndlpeiid dndgivteff ierclyyqkl lhpidlwskp 421 flstiefqvs ssskllhhef ssspflnvti tgfsgvellh ltkvlnllkp mginyveyln 481 kstdillinl aalpsipkth plwsnefsdl ftqfcinnnn ddpgdnnrkd fqnnsilrns 541 mkrkieyikk fhsipvvtpa fifkllsaas genneiflnn ikwciicprg hkddfkckik 601 kpyytsisse kkyqnndpki dktillkrnn sslsehsmkd tknellqkir etdsgrkkrs 661 vsssimdvss erqmpdtkri kleslpknfv pkqikrttsw gtimsenvpt eqptaisnpe 721 eiprteevsh tqvtygsiqd kkrtaslekp mrrqtrnqtk elds // LOCUS NP_012446 829 aa linear PLN 30-JUN-2025 DEFINITION Sip4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012446 VERSION NP_012446.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181522.1 REFERENCE 1 (residues 1 to 829) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 829) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 829) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 829) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 829) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 829) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 829) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08711. Method: conceptual translation. FEATURES Location/Qualifiers source 1..829 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..829 /product="Sip4p" /calculated_mol_wt="95874" Region 40..82 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(41,45,50..53,55,58,68) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(46,49,56,63,66,73) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 85..>102 /region_name="ZIP_Sip4" /note="Leucine zipper Dimerization domain transcription factor Sip4p and similar fungal proteins; cd15486" /db_xref="CDD:271244" CDS 1..829 /gene="SIP4" /locus_tag="YJL089W" /coded_by="NM_001181522.1:1..2490" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:14685767|PMID:11405098|PMID:9843506]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:14685767]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9843506|PMID:11331606]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:genetic interaction:GO:0045722 positive regulation of gluconeogenesis [PMID:25123508]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:25123508]" /experiment="EXISTENCE:mutant phenotype:GO:0045722 positive regulation of gluconeogenesis [PMID:9843506]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9843506]" /experiment="EXISTENCE:mutant phenotype:GO:2000218 negative regulation of invasive growth in response to glucose limitation [PMID:11095711]" /experiment="EXISTENCE:physical interaction:GO:0045722 positive regulation of gluconeogenesis [PMID:9843506]" /note="C6 zinc cluster transcriptional activator; binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus" /db_xref="GeneID:853356" /db_xref="SGD:S000003625" ORIGIN 1 makrkygrsy slddtdscsn kvlivptgqs ssnaitdfsv rkahacdrcr lkkikcdglk 61 pncsncakid fpcktsdkls rrglpkgyte llekevvrlt nmnasssana nsnlpfindt 121 fycfdnyntq senqrflghl twniltntfp tqkavvftdd rnnidlqlql ltnflnlngd 181 fnhlpnflll kydynlqflk nllsviikdf fkrqnsllll lyptnlwknl lldkinstam 241 tgepitllal lyiiqftwsc fddfklfkvt klivslttns kldlkvlqlv nlsifyfmga 301 svdsckskss ltehsnvnsv iwtndllnln ftnilnmgly inpknlipis gnnnnnksne 361 eddrivtfwc fqflsswwsl iqglpksnfl teefqpksis vleiprlkpf eillnfiiys 421 ldgcnllnis slnvsdpnfq ffqnelesfk knlllwnlyh nlsdhdnfrf ltsssnkklt 481 tnlllknltg lnhklnqpdf veiqltlfyl slklmtlkeg dqdlkkedis leilslyfli 541 ltddsnnddn qqlqpqqlnl yhftpfnsid iidlclnnln nwslslkyes gqnqphsski 601 kfekfqnfln hwcpiwyyde fstnpflqil kinfkllpfe tihysqeeqr llislnklry 661 ldavssfnss svksnfaskv ntqlnllqhs ssnsnfldas pydfnkifmn nfenydyetd 721 egyaedddee dsdsdnslpl eipfkksknk cknrnkelsq rlslfenrds nsvdfntdtn 781 lnlnpdspsv tsskkkyldh iildnrdivs nhdsskqkfk iqnilnstf // LOCUS NP_012447 338 aa linear PLN 30-JUN-2025 DEFINITION ornithine carbamoyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012447 VERSION NP_012447.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181521.1 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 338) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08712. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..338 /product="ornithine carbamoyltransferase" /EC_number="2.1.3.3" /calculated_mol_wt="37714" Region 12..329 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" CDS 1..338 /gene="ARG3" /locus_tag="YJL088W" /coded_by="NM_001181521.1:1..1017" /experiment="EXISTENCE:direct assay:GO:0004585 ornithine carbamoyltransferase activity [PMID:7029528]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:205532]" /experiment="EXISTENCE:mutant phenotype:GO:0006526 L-arginine biosynthetic process [PMID:2897249]" /note="Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline" /db_xref="GeneID:853357" /db_xref="SGD:S000003624" ORIGIN 1 msttastpss lrhlisikdl sdeefrilvq raqhfknvfk anktndfqsn hlkllgrtia 61 liftkrstrt ristegaatf fgaqpmflgk ediqlgvnes fydttkvvss mvscifarvn 121 khedilafck dssvpiinsl cdkfhplqai cdlltiienf nisldevnkg insklkmawi 181 gdannvindm ciaclkfgis vsistppgie mdsdivdeak kvaerngatf elthdslkas 241 tnanilvtdt fvsmgeefak qaklkqfkgf qinqelvsva dpnykfmhcl prhqeevsdd 301 vfygehsivf eeaenrlyaa msaidifvnn kgnfkdlk // LOCUS NP_012448 827 aa linear PLN 30-JUN-2025 DEFINITION tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012448 VERSION NP_012448.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181520.1 REFERENCE 1 (residues 1 to 827) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 827) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 827) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 827) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08713. Method: conceptual translation. FEATURES Location/Qualifiers source 1..827 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..827 /product="tRNA ligase" /EC_number="6.5.1.3" /calculated_mol_wt="95206" Region 64..292 /region_name="RNA_lig_T4_1" /note="RNA ligase; pfam09511" /db_xref="CDD:462821" Region 393..561 /region_name="tRNA_lig_kinase" /note="tRNA ligase kinase domain; pfam08303" /db_xref="CDD:400549" Region 565..826 /region_name="tRNA_lig_CPD" /note="Fungal tRNA ligase phosphodiesterase domain; pfam08302" /db_xref="CDD:400548" CDS 1..827 /gene="TRL1" /locus_tag="YJL087C" /gene_synonym="LIG1; RLG1" /coded_by="NM_001181520.1:1..2484" /experiment="EXISTENCE:direct assay:GO:0003972 RNA ligase (ATP) activity [PMID:3277966|PMID:3512545]" /experiment="EXISTENCE:direct assay:GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity [PMID:6297798]" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:3312232]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20844078]" /experiment="EXISTENCE:direct assay:GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation [PMID:2207062]" /experiment="EXISTENCE:direct assay:GO:0051730 GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity [PMID:8428918]" /experiment="EXISTENCE:mutant phenotype:GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation [PMID:1537841]" /experiment="EXISTENCE:mutant phenotype:GO:0032056 positive regulation of translation in response to stress [PMID:20844078]" /experiment="EXISTENCE:mutant phenotype:GO:0036498 IRE1-mediated unfolded protein response [PMID:8898194]" /experiment="EXISTENCE:mutant phenotype:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:31913314]" /experiment="EXISTENCE:mutant phenotype:GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:30874502]" /note="tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; involved in turnover of tRNA introns; localized at the inner nuclear envelope and cytoplasm" /db_xref="GeneID:853358" /db_xref="SGD:S000003623" ORIGIN 1 mpspydgkrt vtqlvnelek aeklsgrgra yrrvcdlshs nkkviswkfn ewdygkntit 61 lpcnarglfi sddttnpviv argydkffnv gevnftkwnw ieenctgpyd vtikangcii 121 fisgledgtl vvcskhstgp radvdrnhae agekqllrql aamninrsdf armlythnvt 181 avaeycddsf eehileyple kaglylhgvn vnkaefetwd mkdvsqmask ygfrcvqcit 241 sntledlkkf ldncsatgsf egqeiegfvi rchlkstekp fffkykfeep ylmyrqwrev 301 tkdyisnksr vfkfrkhkfi tnkyldfaip ilesspkice nylkgfgvie lrnkflqsyg 361 msgleilnhe kvaelelkna idydkvdert kflifpisvi gcgktttsqt lvnlfpdswg 421 hiqndditgk dksqlmkksl ellskkeikc vivdrnnhqf rerkqlfewl nelkedylvy 481 dtnikvigvs fapydklsei rditlqrvik rgnnhqsikw delgekkvvg imngflkryq 541 pvnldkspdn mfdlmieldf gqadssltna kqilneihka ypilvpeipk ddeietafrr 601 sldykptvrk ivgkgnnnqq ktpklikpty isakienyde iielvkrcia sdaeltekfk 661 hllasgkvqk elhitlghvm ssrekeakkl wksycnrytd qiteynnnri enaqgsgnnq 721 ntqvkttdkl nfrleklcwd ekiiaivvel skdkdgciid ennekikglc cqnkiphitl 781 cklesgvkav ysnvlcekve saevdenikv vkldnskefv gsvylnf // LOCUS NP_012450 623 aa linear PLN 30-JUN-2025 DEFINITION GTP-Rho binding exocyst subunit EXO70 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012450 VERSION NP_012450.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181518.1 REFERENCE 1 (residues 1 to 623) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 623) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 623) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 623) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08714. Method: conceptual translation. FEATURES Location/Qualifiers source 1..623 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..623 /product="GTP-Rho binding exocyst subunit EXO70" /calculated_mol_wt="71163" Region 236..620 /region_name="Exo70" /note="Exo70 exocyst complex subunit; pfam03081" /db_xref="CDD:460798" CDS 1..623 /gene="EXO70" /locus_tag="YJL085W" /coded_by="NM_001181518.1:1..1872" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:18195105]" /experiment="EXISTENCE:direct assay:GO:0000145 exocyst [PMID:8978675]" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:17717527]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17717527]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922|PMID:10207081|PMID:18946089|PMID:17717527]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:18946089|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0007266 Rho protein signal transduction [PMID:19955214]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:10588647]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:15583030|PMID:17717527]" /experiment="EXISTENCE:genetic interaction:GO:0007266 Rho protein signal transduction [PMID:19955214]" /experiment="EXISTENCE:genetic interaction:GO:0051601 exocyst localization [PMID:17717527|PMID:18946089]" /experiment="EXISTENCE:mutant phenotype:GO:0001927 exocyst assembly [PMID:18946089|PMID:15583030]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:17339375]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:17339375]" /experiment="EXISTENCE:physical interaction:GO:0007266 Rho protein signal transduction [PMID:19955214]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:10207081|PMID:19955214]" /note="Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress" /db_xref="GeneID:853359" /db_xref="SGD:S000003621" ORIGIN 1 mpaeididea dvlvlsqelq ktskltfein kslkkiaats nqssqlftpi larnnvlttl 61 qrniestlns vasvkdlane askyeiilqk ginqvglkqy tqvvhklddm lediqsgqan 121 reensefhgi lthleqlikr seaqlrvyfi silnsikpfd pqinitkkmp fpyyedqqlg 181 alswildyfh gnsegsiiqd ilvgerskli lkcmaflepf akeistakna pyekgssgmn 241 syteallgfi anekslvddl ysqyteskph vlsqilspli sayaklfgan lkivrsnlen 301 fgffsfelve sindvkkslr gkelqnynll qdctqevrqv tqslfrdaid riikkansis 361 tipsnngvte atvdtmsrlr kfseykngcl gamdnitren wlpsnykeke ytlqnealnw 421 edhnvllscf isdcidtlav nlerkaqial mpnqepdvan pnssknkhkq rigffilmnl 481 tlveqiveks elnlmlageg hsrlerlkkr yisymvsdwr dltanlmdsv fidssgkksk 541 dkeqikekfr kfnegfedlv sktkqyklsd pslkvtlkse iislvmpmye rfysrykdsf 601 knprkhikyt pdelttvlnq lvr // LOCUS NP_012451 1046 aa linear PLN 30-JUN-2025 DEFINITION Aly2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012451 VERSION NP_012451.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181517.1 REFERENCE 1 (residues 1 to 1046) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1046) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1046) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1046) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1046) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1046) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1046) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08715. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1046 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1046 /product="Aly2p" /calculated_mol_wt="117086" Region <254..341 /region_name="Arrestin_N" /note="Arrestin (or S-antigen), N-terminal domain; cl22903" /db_xref="CDD:451447" Region 360..526 /region_name="Arrestin_C" /note="Arrestin (or S-antigen), C-terminal domain; smart01017" /db_xref="CDD:214976" Region 620..>924 /region_name="PTZ00112" /note="origin recognition complex 1 protein; Provisional" /db_xref="CDD:240274" CDS 1..1046 /gene="ALY2" /locus_tag="YJL084C" /gene_synonym="ART3" /coded_by="NM_001181517.1:1..3141" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:20739461]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:20739461]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0051453 regulation of intracellular pH [PMID:38248315]" /experiment="EXISTENCE:mutant phenotype:GO:0032386 regulation of intracellular transport [PMID:20739461]" /experiment="EXISTENCE:mutant phenotype:GO:0070086 ubiquitin-dependent endocytosis [PMID:32800549]" /experiment="EXISTENCE:mutant phenotype:GO:1903577 cellular response to L-arginine [PMID:32800549]" /experiment="EXISTENCE:mutant phenotype:GO:2000397 positive regulation of ubiquitin-dependent endocytosis [PMID:20956561]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:20956561]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]" /note="Alpha arrestin, Ub-ligase adaptor for Rsp5p; controls nutrient limitation-mediated endosomal recycling of the Gap1p amino acid permease; PY motif-containing adaptor involved in substrate-induced, Rsp5p-mediated ubiquitination and endocytosis of select plasma membrane localized amino acid transporters, such as Dip5p and Put4p; regulates intracellular pH; phosphorylated by Npr1p and by the Pcl7p-Pho85p cyclin-CDK complex; interacts with AP-1 subunit Apl4p" /db_xref="GeneID:853361" /db_xref="SGD:S000003620" ORIGIN 1 mpmdqsissp lfpmekdidi pldatplaqs sslqlfihla epvvflqgfd pqkteypsvv 61 lrgclvvril kptklksisl sfkgysrtew pegippkrqe fveikdivdh twalyppteq 121 kskkkmdasa pnesnnaann fltkesgasl yrtlsdneti tsrknsisgl sslnlsplga 181 pgnssvnvkd resrqrsrss svtssngpsr nlspinllkr atspsvshhn ykptttsifs 241 dllnntfthn daashhghhi ptssnhlamt snnftsgsgg effvfqpgdy iyafeelipq 301 aypesikadf gfveyflfas ierpgafksn isarqvvniv rtqahnsvee sepiiisrdw 361 enqlyydivi askdiildaf lpitfkfapl dkvtlhriri yvtetmeyyc rekkvhrmep 421 tkkfllteqk gpklpnlpnd anlskaknmg nllqdpkngd lvnkeyeyqi fipsrfnnhq 481 qlhpdtsyen ikanhwikic lrlsrvvdnk rkhyeisids pihvlhrlcs hantllpsyd 541 ghpasfpket dssissiles sddninlyhn sniffpkevl sspvlspnvq pldiliphlp 601 stsltrnsrq fnrnskshps dntifnsakl ksniyqpesl qrelaspqai plspitspms 661 nmevpppdfd fssdfisdaa sgttttevss sessilprdp psykdtvlhd nnqkrrpnsk 721 hptppslkas hpnknsdkns setlnkkesm skieenkhkr ettpkkrenr dvkslstpqr 781 eeskdststg nqsneknrkr vlslssslhs spnnsgfahs algnlsnesl rslnrresvq 841 dnlpstirhd npfftdlnqv liedelknhd knelnrhstn tsstpasars sfdysginis 901 kdklnmepll sktetltnkv nedsflrpnd syvdllepsv dttiditapy arnssawhpl 961 qndndnnqfs pllgsnenfl naanaqnsae sdhnndiftq gsgltesskn sdseerfisr 1021 lsspekvlin tldnesglqs inestl // LOCUS NP_012452 604 aa linear PLN 30-JUN-2025 DEFINITION Tax4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012452 VERSION NP_012452.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181516.1 REFERENCE 1 (residues 1 to 604) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 604) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 604) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 604) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08716. Method: conceptual translation. FEATURES Location/Qualifiers source 1..604 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..604 /product="Tax4p" /calculated_mol_wt="68637" Region 463..557 /region_name="EH" /note="Eps15 homology domain; smart00027" /db_xref="CDD:197477" CDS 1..604 /gene="TAX4" /locus_tag="YJL083W" /coded_by="NM_001181516.1:1..1815" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18298591]" /experiment="EXISTENCE:genetic interaction:GO:0006914 autophagy [PMID:18298591]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:18298591]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:15265867]" /note="EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; TAX4 has a paralog, IRS4, that arose from the whole genome duplication" /db_xref="GeneID:853362" /db_xref="SGD:S000003619" ORIGIN 1 mhfpkkkhsg nlsvvelpke alqdsltaaq itfkryahpn gnagsaerpr hlkvesapvv 61 ksepslprmr qpeprsinhq ysretlpghs eafsvpttpl qtihydvrnk asnspssiaa 121 aetaaylaht nsfsnrssgv gsrdpvmdte tkpprapsal knelqlnrmr ipppsydnnv 181 rsrsispqvs ystslssscs issdgeetsy rekstdeafp pepsmssysl askasakasl 241 tdpsqrqqes dytamnklng gniiykgtlp dliprsqrkt skprfkhrll rspeqqqenl 301 srvysdqtqn graiintqqn vklkttmrrg kyaitdndet fpydrksvss dsdtdedsnv 361 meikdkkkks rrskikkglk ttaavvgsst svlpfphhhh hhhqlhnpns hhlhthhhts 421 shkfnedkpw kshrdlgfit eqerkryesm wvsnrysylr llpwwpslan eddeshlqpl 481 nlpqdglmln lvvkdiwyrs nlprdllvqi ynmvdtrkdg tldrksfivg mwlvdqclyg 541 rkltneldqr vwnsvdgyvl gtinvkpats dhyhnannpl dkpsklsvrq elknikrdlr 601 nvri // LOCUS NP_012453 731 aa linear PLN 30-JUN-2025 DEFINITION Iml2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012453 VERSION NP_012453.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181515.1 REFERENCE 1 (residues 1 to 731) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 731) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 731) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 731) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08717. Method: conceptual translation. FEATURES Location/Qualifiers source 1..731 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..731 /product="Iml2p" /calculated_mol_wt="82405" Region 38..622 /region_name="Iml2-TPR_39" /note="Iml2/Tetratricopeptide repeat protein 39; pfam10300" /db_xref="CDD:463047" CDS 1..731 /gene="IML2" /locus_tag="YJL082W" /coded_by="NM_001181515.1:1..2196" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0071218 cellular response to misfolded protein [PMID:26004510]" /note="Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication" /db_xref="GeneID:853363" /db_xref="SGD:S000003618" ORIGIN 1 mfrvfgsfgs kgnqssgeeq stktkqvlkq andfeialka mdfvlddrtd eglnllkkae 61 metgsdqtil tlargviefl qatlsfetee mkraaitlgk aeqmswkskq naektnfrss 121 siyppgtvya vtytescllh allmlfsesm meaakallkl rraytmlqdi mvtvkkaers 181 knssspspse ksqescgsfv saettfisvd ipyklssedk snplllefae kiytmrmgrl 241 sgahigntps fhrlrddlgl qttpsqasdr hsvsddfdle qatidefihs ganlcygilq 301 vvlsllppai gavlsivgfk gsreeglrlv wkatkernvh gcigllglmf yydgpfqftd 361 adfdippndn gsralnksrt ndssllpgym dsatllhpgk iledallkar alfpnsalwl 421 lneakmlagk grlrdslalm dsidvnsirm rqvkslmvfe raillvnlhe ynraaddlis 481 lldisdwsha lytyfagccy lenwrmtqlg llndgkeqfy kerarelifd apsllgkktf 541 ksknlpldrf mlrkvqqfnn mqkklnlqep ldsiatspvh elayfyngyn rmtendlilt 601 kkmlteyhnp aidsedpdqe lirnlllslt lrrlgdaerg lallddivlp kifyiqngkv 661 kyfkktedpw aypaalyera lfcwklggme slnecrewll raqnyaadye lstrigmkik 721 aaldrvenal a // LOCUS NP_012454 489 aa linear PLN 30-JUN-2025 DEFINITION Arp4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012454 VERSION NP_012454.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181514.1 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 489) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08718. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..489 /product="Arp4p" /calculated_mol_wt="54701" Region 11..479 /region_name="ASKHA_NBD_Arp4_ACTL6-like" /note="nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; cd13395" /db_xref="CDD:466846" CDS 1..489 /gene="ARP4" /locus_tag="YJL081C" /gene_synonym="ACT3" /coded_by="NM_001181514.1:1..1470" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10436015]" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14690608|PMID:14645854|PMID:16299513]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10436015]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:16088870]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11011149|PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:12353039|PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:10911987]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15610740]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:10436015]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:8598290]" /experiment="EXISTENCE:mutant phenotype:GO:0051382 kinetochore assembly [PMID:17452364]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245|PMID:10952318]" /note="Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes" /db_xref="GeneID:853364" /db_xref="SGD:S000003617" ORIGIN 1 msnaalqvyg gdevsavvid pgsyttnigy sgsdfpqsil psvygkytad egnkkifseq 61 sigiprkdye lkpiienglv idwdtaqeqw qwalqnelyl nsnsgipall tepvwnsten 121 rkkslevlle gmqfeacyla ptstcvsfaa grpnclvvdi ghdtcsvspi vdgmtlskst 181 rrnfiagkfi nhlikkalep keiiplfaik qrkpefikkt fdyevdksly dyannrgffq 241 ecketlchic ptktleetkt elsstakrsi espwneeivf dnetrygfae elflpkeddi 301 panwprsnsg vvktwrndyv plkrtkpsgv nksdkkvtpt eekeqeavsk stspaansad 361 tpnetgkrpl eeekppkenn eligladlvy ssimssdvdl ratlahnvvl tggtssipgl 421 sdrlmtelnk ilpslkfril ttghtierqy qswlggsilt slgtfhqlwv gkkeyeevgv 481 erllndrfr // LOCUS NP_012455 1222 aa linear PLN 30-JUN-2025 DEFINITION Scp160p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012455 VERSION NP_012455.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181513.1 REFERENCE 1 (residues 1 to 1222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1222) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08719. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1222 /product="Scp160p" /calculated_mol_wt="134679" Region <170..>402 /region_name="235kDa-fam" /note="reticulocyte binding/rhoptry protein; TIGR01612" /db_xref="CDD:130673" Region 172..257 /region_name="KH-I_ScSCP160_rpt1" /note="first type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins; cd22446" /db_xref="CDD:411874" Site order(187,189..191,193..197,200..201,204..205,210..213) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:411874" Region <502..>606 /region_name="Glyco_tranf_GTA_type" /note="Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; cl11394" /db_xref="CDD:472172" Region 632..707 /region_name="KH-I_ScSCP160_rpt2" /note="second type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins; cd22447" /db_xref="CDD:411875" Site order(644,646..648,650..654,657..658,661..662,667..670) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:411875" Region 711..777 /region_name="KH-I_ScSCP160_rpt3" /note="third type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins; cd22448" /db_xref="CDD:411876" Site order(722,724..726,728..732,735..736,739..740,745..748) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:411876" Region 780..857 /region_name="KH-I_ScSCP160_rpt4" /note="fourth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins; cd22449" /db_xref="CDD:411877" Site order(792,794..796,798..802,805..806,809..810,815..818) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:411877" Region 859..935 /region_name="KH-I_ScSCP160_rpt5" /note="fifth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins; cd22450" /db_xref="CDD:411878" Site order(871,873..875,877..881,884..885,888..889,900..903) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:411878" Region 940..1008 /region_name="KH-I_ScSCP160_rpt6" /note="sixth type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins; cd22451" /db_xref="CDD:411879" Site order(949,951..953,955..959,962..963,966..967,972..975) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:411879" Region 1152..1218 /region_name="KH-I_ScSCP160_rpt7" /note="seventh type I K homology (KH) RNA-binding domain found in Saccharomyces cerevisiae Protein SCP160 and similar proteins; cd22452" /db_xref="CDD:411880" Site order(1163,1165..1167,1169..1173,1176..1177,1180..1181, 1186..1189) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:411880" CDS 1..1222 /gene="SCP160" /locus_tag="YJL080C" /coded_by="NM_001181513.1:1..3669" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:11278502]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:22832273|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11278502]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:8533468]" /experiment="EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:14536090]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:16632467]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:8533468]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16632467]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16632467]" /experiment="EXISTENCE:mutant phenotype:GO:0043577 chemotropism [PMID:22832273]" /experiment="EXISTENCE:mutant phenotype:GO:0045141 meiotic telomere clustering [PMID:16632467]" /experiment="EXISTENCE:physical interaction:GO:0001965 G-protein alpha-subunit binding [PMID:14536090]" /note="Essential RNA-binding G protein effector of mating response pathway; ligand-activated RNA-binding protein that delivers RNAs involved in polarization and perpetualizing mating signal to shmoo tip during pheromone signaling; Scp160p-mediated RNA trafficking essential for chemotropism and successful mating; mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins" /db_xref="GeneID:853365" /db_xref="SGD:S000003616" ORIGIN 1 mseeqtaids ppstvegsve tvttidspst tastiaatae ehpqlekkpt plpslkdlps 61 lgsnaafanv kvswgpnmkp avsnspspsp sapslttglg akrmrskniq eaftldlqsq 121 lsitkpelsr ivqsvkknhd vsvestlskn artflvsgva anvheakrel vkkltkpina 181 vievpskcka siigsggrti reisdayevk invskevnen sydedmddtt snvslfgdfe 241 svnlakakil aivkeetkna tiklvvedek ylpyidvsef asdegdeevk vqfykksgdi 301 vilgprekak atktsiqdyl kklasnldee kvkipskfqf lidaeelkek ynvivtfpst 361 pddelvsfvg lrdkvgeait yarsssksyv vesldiskah sknlthaknl imyftkysvl 421 kgleeshpnv kislpsiqsl ptaetvtihi saksdeandi kavrkelisf vnnippsetl 481 vitdldyelf ggsikhclla sessvafvqf gdyypndnsi llvalteded fkpsieeiqa 541 slnkanesln slrtkqnnme tktyefseev qdslfkpssa twklimedis eqeghlqikl 601 htpeenqltv rgdekaakaa nkifesilns psskskmtvn ipansvarli gnkgsnlqqi 661 rekfacqidi pneennnask dktvevtltg leynlthakk ylaaeakkwa diitkelivp 721 vkfhgsligp hgtyrnrlqe kynvfinfpr dneivtirgp srgvnkahee lkalldfeme 781 nghkmvinvp aehvpriigk ngdnindira eygvemdflq kstdpkaqet geveleitgs 841 rqnikdaakr vesivaeasd fvtevlkidh kyhksivgsg ghilreiisk aggeeirnks 901 vdipnadsen kditvqgpqk fvkkvveein kivkdaensv tktidipaer kgaligpggi 961 vrrqlesefn inlfvpnkdd psgkititga penvekaekk ilneiirenf drevdvpasi 1021 yeyvsergaf iqklrmdlsv nvrfgntskk anklarapie iplekvcgst egenaektkf 1081 tieevgapts seegditmrl tyepidlssi lsdgeekevt kdtsndsakk eealdtavkl 1141 ikeriakaps atyagyvwga dtrrfnmivg pggsnikkir eaadviinvp rksdkvndvv 1201 yirgtkagve kagemvlksl rr // LOCUS NP_012456 299 aa linear PLN 30-JUN-2025 DEFINITION sterol-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012456 VERSION NP_012456.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181512.1 REFERENCE 1 (residues 1 to 299) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 299) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 299) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 299) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08720. Method: conceptual translation. FEATURES Location/Qualifiers source 1..299 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..299 /product="sterol-binding protein" /calculated_mol_wt="30503" Region 166..289 /region_name="CAP_PRY1-like" /note="CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; cd05384" /db_xref="CDD:349403" CDS 1..299 /gene="PRY1" /locus_tag="YJL079C" /coded_by="NM_001181512.1:1..900" /experiment="EXISTENCE:direct assay:GO:0000287 magnesium ion binding [PMID:27344972]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005504 fatty acid binding [PMID:28365570]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:23027975]" /experiment="EXISTENCE:genetic interaction:GO:0015908 fatty acid transport [PMID:28365570]" /experiment="EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:23027975]" /experiment="EXISTENCE:mutant phenotype:GO:0005504 fatty acid binding [PMID:28365570]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:23027975]" /experiment="EXISTENCE:mutant phenotype:GO:0032934 sterol binding [PMID:23027975]" /note="Lipid binding protein; binds to both free fatty acids with preference for saturated long-chain fatty acids and to sterols; contains two independent lipid-binding sites; involved in the export of free fatty acids and acetylated sterols; export functions are redundant with PRY2, and PRY3; important for survival of cells that accumulate free fatty acids; involved in detoxification of hydrophobic compounds; secreted glycoprotein and member of the CAP/SCP protein superfamily" /db_xref="GeneID:853366" /db_xref="SGD:S000003615" ORIGIN 1 mklsklsilt salatsalaa pavvtvteha heaavvtvqg vvyvengqtr ttyetlapas 61 tatptstata lvappvapss assnsdvvls alknlasvwg kttdstttlt ssestsqsla 121 qatttstpaa asttstpaat tttsqaaats sasssdsdls dfassvlaeh nkkralhkdt 181 palswsdtla syaqdyadny dcsgtlthsg gpygenlalg ydgpaavdaw yneisnydfs 241 npgfssntgh ftqvvwkstt qvgcgiktcg gawgdyvics ydpagnyege yadnvepla // LOCUS NP_012457 881 aa linear PLN 30-JUN-2025 DEFINITION Pry3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012457 VERSION NP_012457.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181511.1 REFERENCE 1 (residues 1 to 881) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 881) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 881) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 881) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08721. Method: conceptual translation. FEATURES Location/Qualifiers source 1..881 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..881 /product="Pry3p" /calculated_mol_wt="89022" Region 24..152 /region_name="CAP_PRY1-like" /note="CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; cd05384" /db_xref="CDD:349403" Region <449..>709 /region_name="ser_rich_anae_1" /note="serine-rich protein; NF033849" /db_xref="CDD:468206" CDS 1..881 /gene="PRY3" /locus_tag="YJL078C" /coded_by="NM_001181511.1:1..2646" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:32554483|PMID:15781460|PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015908 fatty acid transport [PMID:28365570]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:32554483]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:23027975]" /note="GPI-anchored cell wall protein involved in export of sterols; redundant role with PRY1 and PRY2 in the export of free fatty acids; role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p; member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)" /db_xref="GeneID:853367" /db_xref="SGD:S000003614" ORIGIN 1 mlefpisvll gclvavkaqt tfpnfesdvl nehnkfralh vdtapltwsd tlatyaqnya 61 dqydcsgvlt hsdgpygenl algytdtgav dawygeisky nysnpgfses tghftqvvwk 121 staeigcgyk ycgttwnnyi vcsynppgny lgefaeevep listvsssss sssststtsd 181 tvstisssim pavaqgyttt vssaassssl ksttinpakt atltassstv itsstesvgs 241 stvssassss vttsyatsss tvvssdatss ttttssvats ssttssdpts staaasssdp 301 asssaaasss astenaasss saisssssmv saplsstltt stassrsvts nsvnsvkfan 361 ttvfsaqtts svsaslsssv aaddiqgsts keatssvseh tsivtsatna aqyatrlgss 421 srsssgavss savsqsvlns viavntdvsv tsvsstahtt kdtattsvta sesitsetaq 481 asssteknis nsaatsssiy snsasvsghg vtyaaeyait seqssalats vpatncssiv 541 ktttlensst ttitaitkst ttlattanns traatavtid ptldptdnsa sptdnakhts 601 tygssstgas ldslrtttsi svssnttqlv stctsesdys dspsfaista tttesnlitn 661 titascstds nfptsaasst detaftrtis tscstlngas tqtselttsp mktntvvpas 721 sfpsttttcl enddtafssi ytevnaatii npgetsslas dfatsekpne ptsvkstsne 781 gtssttttyq qtvatlyakp sstslgartt tgsngrstts qqdgsamhqp tssiytqlke 841 gtsttaklsa yegaatplsi fqcnslagti aafvvavlfa f // LOCUS NP_878104 32 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL077W-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878104 VERSION NP_878104.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184603.1 REFERENCE 1 (residues 1 to 32) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 32) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 32) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 32) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 32) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 32) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 32) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08722. Method: conceptual translation. FEATURES Location/Qualifiers source 1..32 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..32 /product="uncharacterized protein" /calculated_mol_wt="3884" CDS 1..32 /locus_tag="YJL077W-B" /coded_by="NM_001184603.1:1..99" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466467" /db_xref="SGD:S000028662" ORIGIN 1 mpilvwqlpk skklktlkyr icfreffdrv et // LOCUS NP_012458 131 aa linear PLN 30-JUN-2025 DEFINITION Ics3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012458 VERSION NP_012458.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181510.1 REFERENCE 1 (residues 1 to 131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 131) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08723. Method: conceptual translation. FEATURES Location/Qualifiers source 1..131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..131 /product="Ics3p" /calculated_mol_wt="14697" CDS 1..131 /gene="ICS3" /locus_tag="YJL077C" /coded_by="NM_001181510.1:1..396" /experiment="EXISTENCE:mutant phenotype:GO:0055070 copper ion homeostasis [PMID:26127016]" /note="Protein with a role in copper homeostasis; possible role in vacuolar sorting and processing of secretory proteins; null mutants are hypersensitive to sortin2" /db_xref="GeneID:853368" /db_xref="SGD:S000003613" ORIGIN 1 mhislptrnk syfrirtrty qiglyhsdss pirdisvlhl liatlctiff piffslskvq 61 vvqwqgttis kncialtmsf plnaipgmyl iiafprlqtv iplqrntpvr itksvivkga 121 vsvprisspm h // LOCUS NP_001257682 28 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL077W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257682 VERSION NP_001257682.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270753.1 REFERENCE 1 (residues 1 to 28) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 28) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 28) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 28) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35120. Method: conceptual translation. FEATURES Location/Qualifiers source 1..28 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..28 /product="uncharacterized protein" /calculated_mol_wt="2947" CDS 1..28 /locus_tag="YJL077W-A" /coded_by="NM_001270753.1:1..87" /note="hypothetical protein; mRNA identified as translated by ribosome profiling data; completely overlaps the verified gene YJL077C/ICS3" /db_xref="GeneID:13393612" /db_xref="SGD:S000028661" ORIGIN 1 mpgiafkgkd mvkaiqflei vvpchctt // LOCUS NP_012459 1189 aa linear PLN 30-JUN-2025 DEFINITION Net1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012459 VERSION NP_012459.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181509.1 REFERENCE 1 (residues 1 to 1189) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1189) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1189) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1189) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08724. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1189 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1189 /product="Net1p" /calculated_mol_wt="128400" Region 71..142 /region_name="Cytokin_check_N" /note="Cdc14 phosphatase binding protein N-terminus; pfam10407" /db_xref="CDD:431263" Region 691..>950 /region_name="PRK08581" /note="amidase domain-containing protein" /db_xref="CDD:236304" CDS 1..1189 /gene="NET1" /locus_tag="YJL076W" /gene_synonym="CFI1; ESC5; SRM8" /coded_by="NM_001181509.1:1..3570" /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:10219245]" /experiment="EXISTENCE:direct assay:GO:0004864 protein phosphatase inhibitor activity [PMID:10219244]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10219244]" /experiment="EXISTENCE:direct assay:GO:0030869 RENT complex [PMID:10219244]" /experiment="EXISTENCE:direct assay:GO:1902570 protein localization to nucleolus [PMID:33481703]" /experiment="EXISTENCE:genetic interaction:GO:0001100 negative regulation of exit from mitosis [PMID:10219244]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:10219245]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:26090959|PMID:10219244]" /experiment="EXISTENCE:mutant phenotype:GO:0007000 nucleolus organization [PMID:10219245]" /experiment="EXISTENCE:mutant phenotype:GO:1904751 positive regulation of protein localization to nucleolus [PMID:10219244]" /note="Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication" /db_xref="GeneID:853369" /db_xref="SGD:S000003612" ORIGIN 1 myklqvvlvp pslqatmpiq fgygptiaes sqllpnrtnm aqsagdaslq yanlrsanvs 61 ftpsyfnqsr frkfllftkp tntllnlsde iidkcekmyp slqedieils lqdnsgcdld 121 pdflvkdvfn vnnivrvilk neidlddsap vslyksvkrs klnngspqsv qpqqqipsss 181 gvlriakkrp ptgtttttti rsatngsmrv stplarqiyp ppsskivsnn sddededige 241 rsflppptqp qsppirissg idagkkikss iveedivsrs atvdpdktkq qrllsgtpim 301 stmtpnrvtl tgqrvvseha hknelvfsas assssfangg taavtaqdin rkppvttpri 361 tsgmlkipep riseiekelk egpsspasil pakaakipmk kpylengeny esddssssen 421 qetpetephs kaslqrsqss iadnngspvk nsplgdamph nvhlaelpka sntsitkssn 481 geswgkqqeh qpprksslet ivekksqaep sgivepkrmt nflddnqvre kedtndklle 541 keilptiphn dqpilassdk sngtlkslag kvssnnnask edgtiingti eddgndndev 601 dttvrivpqd sdsssfpksd lfkmiegddt dlpqwfkgkn srtsgnskns kpyttvlnkd 661 idnskpdprn ilpqrtprsa akraaqllag akknevpqks tedsssaast ddesesgiet 721 dfssdddfkr knmsvpnngp kdislhslkg svvpvkdski inkevdeern dkrdsqkksa 781 vsessvtnsk iseqmaksfy pnsnkkqnea tkvetkpatq assfpvvggs psvatkgtts 841 fneegnrknv ktkaknesaq idrqqketts rvadlksani ggedlnkkae gskepekasa 901 niqdandknn skekedsksk qvsqkklkmt dhlkegnvql pkpsandklk dlkakftnsk 961 tlvppgiisn eknnssandd dssssgsste dessssssss deetstsrka rrvvvntpre 1021 pvrssskiea pspsvnkkin atpdkipvtq lmdmssppsv kskttsnpss ilhdlprkvr 1081 pslsslsdlv srgipdvkek tsksneksqt kapsssddes ssdsdsnsss dsvsdsssds 1141 ksesdsddsg dssddgksfi saksasaalg kkkkpsggfa slikdfkkk // LOCUS NP_001381965 138 aa linear PLN 30-JUN-2025 DEFINITION Apq13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381965 VERSION NP_001381965.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395035.1 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 138) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54806. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..138 /product="Apq13p" /calculated_mol_wt="15521" CDS 1..138 /gene="APQ13" /locus_tag="YJL075C" /coded_by="NM_001395035.1:1..417" /note="hypothetical protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps verified gene NET1, but does not share all phenotypes; null mutant is slow-growing, sensitive to heat, sorbate, and other various chemicals" /db_xref="GeneID:853370" /db_xref="SGD:S000003611" ORIGIN 1 mldyffllaf cdvystetfw yhfflksfin danpplgfff lpkaaladfa liklfpssde 61 spessesdsd leselesdte selelesese ldsssllega fvcdfsfdle vfsftsgmpl 121 etrsdnelke grtflgrs // LOCUS NP_012461 1230 aa linear PLN 30-JUN-2025 DEFINITION cohesin subunit SMC3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012461 VERSION NP_012461.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181507.1 REFERENCE 1 (residues 1 to 1230) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1230) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1230) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1230) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08725. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1230 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1230 /product="cohesin subunit SMC3" /calculated_mol_wt="141206" Region 2..1208 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; pfam02463" /db_xref="CDD:426784" CDS 1..1230 /gene="SMC3" /locus_tag="YJL074C" /coded_by="NM_001181507.1:1..3693" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:17055978]" /experiment="EXISTENCE:direct assay:GO:0030892 mitotic cohesin complex [PMID:9990856]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:9335333]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:10412984]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10412984]" /experiment="EXISTENCE:mutant phenotype:GO:0051177 meiotic sister chromatid cohesion [PMID:10412984]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:16888651]" /experiment="EXISTENCE:physical interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:27325700]" /experiment="EXISTENCE:physical interaction:GO:0019901 protein kinase binding [PMID:27325700]" /note="Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member" /db_xref="GeneID:853371" /db_xref="SGD:S000003610" ORIGIN 1 myikrviikg fktyrnetii dnfsphqnvi igsngsgksn ffaairfvls ddysnlkree 61 rqglihqgsg gsvmsasvei vfhdpdhsmi lpsgvlsrgd devtirrtvg lkkddyqlnd 121 rnvtkgdivr mletagfsmn npynivpqgk ivaltnakdk erlqlledvv gaksfevklk 181 aslkkmeete qkkiqinkem gelnsklsem eqerkeleky nelernrkiy qftlydreln 241 evinqmerld gdynntvyss eqyiqeldkr edmidqvskk lssieaslki knatdlqqak 301 lreseisqkl tnvnvkikdv qqqiesneeq rnldsatlke iksiieqrkq klskilpryq 361 eltkeeamyk lqlaslqqkq rdlilkkgey arfkskderd twihseieel kssiqnlnel 421 esqlqmdrts lrkqysaide eieelidsin gpdtkgqled fdselihlkq klsesldtrk 481 elwrkeqklq tvletllsdv nqnqrnvnet msrslangii nvkeiteklk ispesvfgtl 541 gelikvndky ktcaeviggn slfhivvdte etatlimnel yrmkggrvtf iplnrlslds 601 dvkfpsnttt qiqftplikk ikyeprfeka vkhvfgktiv vkdlgqglkl akkhklnait 661 ldgdradkrg vltggyldqh krtrleslkn lnesrsqhkk ileeldfvrn elndidtkid 721 qvngnirkvs ndresvltni evyrtslntk kneklilees lnaiilklek lntnrtfaqe 781 klntfendll qefdselske ekerlesltk eisaahnkln itsdalegit ttidslnael 841 esklipqend leskmsevgd afifglqdel kelqlekesv ekqhenavle lgtvqreies 901 liaeetnnkk llekannqqr lllkkldnfq ksvektmikk ttlvtrreel qqrireigll 961 pedalvndfs ditsdqllqr lndmnteisg lknvnkrafe nfkkfnerrk dlaeraseld 1021 eskdsiqdli vklkqqkvna vdstfqkvse nfeavferlv prgtakliih rkndnandhd 1081 esidvdmdae snesqngkds eimytgvsis vsfnskqneq lhveqlsggq ktvcaialil 1141 aiqmvdpasf ylfdeidaal dkqyrtavat llkelsknaq ficttfrtdm lqvadkffrv 1201 kyenkistvi evnreeaigf irgsnkfaev // LOCUS NP_012462 645 aa linear PLN 30-JUN-2025 DEFINITION Jem1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012462 VERSION NP_012462.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181506.3 REFERENCE 1 (residues 1 to 645) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 645) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 645) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 645) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08726. On Jul 30, 2012 this sequence version replaced NP_012462.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..645 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..645 /product="Jem1p" /calculated_mol_wt="75013" Region 538..>613 /region_name="DnaJ" /note="DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; COG0484" /db_xref="CDD:440252" CDS 1..645 /gene="JEM1" /locus_tag="YJL073W" /gene_synonym="KAR8" /coded_by="NM_001181506.3:1..1938" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:9148890]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:15282802]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:9817751]" /experiment="EXISTENCE:genetic interaction:GO:0051087 protein-folding chaperone binding [PMID:9148890]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:10069807]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11381090]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:9148890]" /note="DnaJ-like chaperone required for nuclear membrane fusion during mating; localizes to the ER membrane; exhibits genetic interactions with KAR2" /db_xref="GeneID:853372" /db_xref="SGD:S000003609" ORIGIN 1 milisgycll vysvilpvli sasklcdlae lqrlnknlkv dteslpkyqw iagqleqncm 61 tadpasenms dviqlanqiy ykigliqlsn dqhlraintf ekivfnetyk gsfgklaekr 121 lqelyvdfgm wdkvhqkddq yakylslnet irnkisskdv sveedisell ritpydvnvl 181 sthidvlfhk laeeidvsla aaiildyeti ldkhlaslsi dtrlsihyvi svlqtfvlns 241 dasfnirkcl sidmdydkck klsltiskln kvnpskrqil dpatyafenk kfrswdriie 301 fylkdkkpfi tpmkilnkdt nfknnyffle eiikqliedv qlsrplaknl fedppitdgf 361 vkpksyyhtd ylvyidsilc qassmspdvk raklaapfck kslrhsltle twkhyqdaks 421 eqkplpetvl sdvwnsnphl lmymvnsiln ksrskphsqf kkqlydqink ffqdnglses 481 tnpyvmknfr llqkqlqtyk ehkhrnfnqq yfqqqqqqqq hqrhqappaa pnydpkkdyy 541 kilgvspsas skeirkayln ltkkyhpdki kanhndkqes ihetmsqine ayetlsdddk 601 rkeydlsrsn prrntfpqgp rqnnmfknpg sgfpfgngfk mnfgl // LOCUS NP_012463 213 aa linear PLN 30-JUN-2025 DEFINITION DNA replication protein PSF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012463 VERSION NP_012463.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181505.1 REFERENCE 1 (residues 1 to 213) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 213) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 213) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 213) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08727. Method: conceptual translation. FEATURES Location/Qualifiers source 1..213 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..213 /product="DNA replication protein PSF2" /calculated_mol_wt="24930" Region 1..199 /region_name="COG5093" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227424" Site order(121,124,149,153,157..158,173,176,178,180..190) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:212550" CDS 1..213 /gene="PSF2" /locus_tag="YJL072C" /gene_synonym="CDC102" /coded_by="NM_001181505.1:1..642" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:genetic interaction:GO:0006261 DNA-templated DNA replication [PMID:12730134]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:12768207]" /experiment="EXISTENCE:physical interaction:GO:0000811 GINS complex [PMID:12768207|PMID:12730134]" /experiment="EXISTENCE:physical interaction:GO:0031261 DNA replication preinitiation complex [PMID:12730134]" /note="Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" /db_xref="GeneID:853373" /db_xref="SGD:S000003608" ORIGIN 1 mslpahlqqt fspeeiqfiv enepikifpr ittrqkirgd drgtgnhtrw qlittddkal 61 nnmvamrste vvlwialllk qqskcsivap qwlttkeldr kiqyekthpd rfselpwnwl 121 vlarilfnka kddfhdpihe lrgkiqdlre irqikvlkgl kylneshlql dnlslleine 181 lrpfiteimd klreihtasl tagtendeee fni // LOCUS NP_012464 574 aa linear PLN 30-JUN-2025 DEFINITION acetyl-CoA:L-glutamate N-acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012464 VERSION NP_012464.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181504.1 REFERENCE 1 (residues 1 to 574) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 574) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 574) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 574) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08728. Method: conceptual translation. FEATURES Location/Qualifiers source 1..574 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..574 /product="acetyl-CoA:L-glutamate N-acetyltransferase" /EC_number="2.3.1.1" /calculated_mol_wt="65479" Region 423..538 /region_name="DUF619-like" /note="DUF619 domain of various N-acetylglutamate Kinases and N-acetylglutamate Synthases; cl14605" /db_xref="CDD:417472" CDS 1..574 /gene="ARG2" /locus_tag="YJL071W" /gene_synonym="HRB574" /coded_by="NM_001181504.1:1..1725" /experiment="EXISTENCE:direct assay:GO:0004042 L-glutamate N-acetyltransferase activity [PMID:11553611]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:205532]" /experiment="EXISTENCE:mutant phenotype:GO:0004042 L-glutamate N-acetyltransferase activity [PMID:11553611]" /experiment="EXISTENCE:mutant phenotype:GO:0006592 ornithine biosynthetic process [PMID:11553611]" /note="Acetylglutamate synthase (glutamate N-acetyltransferase); mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p" /db_xref="GeneID:853374" /db_xref="SGD:S000003607" ORIGIN 1 mwrrifahel kydqpnassk nlilsvlntt atkreakdyl skytndsgqh nhclffirdl 61 hkvapailsq fssvikrlgm lglrpmfvip pspthvniqa elldsivtea dlkplhlkeg 121 ltksrtglyh svfsqesrff dignsnfipi vkpyvyneet asefmtkdvv kfmdclcqgn 181 iphidkffil nnaggipsge rndnahvfin lsqelehlss slshnistlt kreprsqnll 241 hrmevyvkkd eissleceyh dhlenlllmd kvlsnlaata tglittvkaa alssdrknpl 301 vynlltdrsl issslprfkk kdgeidspan mfddhawyel psqqvnaaps nsdavlvttv 361 lkkgvhikty dyktltqfns iglpkkfhvp ekgakpssns pkldinkfks iidqsfkrsl 421 dlhdyikrin gkiatiivig dyegiailty egseensfvy ldkfavlphl kgslgisdii 481 fnlmfkkfpn eilwrsrkdn vvnkwyfqrs vavldlsidl dpehcdekqs qfklfyygnp 541 qyakralrdk krlrefmrsv rdikpswene knis // LOCUS NP_012465 888 aa linear PLN 30-JUN-2025 DEFINITION metallo-dependent hydrolase superfamily protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012465 VERSION NP_012465.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181503.3 REFERENCE 1 (residues 1 to 888) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 888) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 888) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 888) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08729. On Jul 30, 2012 this sequence version replaced NP_012465.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..888 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..888 /product="metallo-dependent hydrolase superfamily protein" /calculated_mol_wt="104133" Region 281..873 /region_name="metallo-dependent_hydrolases" /note="Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; cl00281" /db_xref="CDD:469705" Site order(344,346,640,663,772) /site_type="active" /db_xref="CDD:238617" CDS 1..888 /locus_tag="YJL070C" /coded_by="NM_001181503.3:1..2667" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="Putative metallo-dependent hydrolase superfamily protein; similar to AMP deaminases but lacks key catalytic residues and does not rescue purine nucleotide metabolic defect of quadruple aah1 ade8 amd1 his1 mutant; may regulate purine nucleotide homeostasis as overexpression in an AMD1 strain grown in adenine results in greatly reduced GDP and GTP intracellular levels; not an essential gene; YJL070C has a paralog, YBR284W, that arose from the whole genome duplication" /db_xref="GeneID:853375" /db_xref="SGD:S000003606" ORIGIN 1 mqaverrpsl lfdeyqnsvt kpnetknkea rvlsendgdv spsvlkqkei svddmdmisl 61 ptefdrqmvl gspmffdled eenkidplps vshhygnges dsfvssytps nlktgeetkd 121 lfinpfelvs qmrkryiaas kqdgisnikn dtekwflypk plpkfwrfed dkrfqdpsds 181 dlnddgdstg tgaatphrhg yyypsyftdh yyyytksglk gkgnikvpyt geyfdledyk 241 kqyiyhlsnq entqnplspy sskeesleee fltdvptfqe frddfayiie liqshkfnev 301 srkrlsylld kfelfqylns kkeilanknv pyrdfynsrk vdrdlslsgc isqrqlseyi 361 wekinleper ivyqdpetsr klslrdifqf gcssndqpia iglkliddef ldwyrniyli 421 dyhltpnkva klvgkemrfy llakvflefd nfiegeylae ifikyvihil ekskyqlaqv 481 svnfqfyssg edwykkfsqw llrwklvsyn irwniqiari fpklfkenvv snfqefldli 541 fnplftleke qlpidssvnt diiglqffls nvcsmdlvik esdeyywkef tdmnckpkfw 601 taqgdnptva hymyyiyksl akvnflrsqn lqntitlrny csplssrtsq fgvdlyftdq 661 veslvcnlll cnggllqvep lwdtatmiqy lfylfqipil aaplssvsll nsqkstflkn 721 knvllehdyl kdqetakinp srditvgeqr syetnpfmkm fkmglkisls sksilynssy 781 tleplieeys vaasiyllnp tdlcelsrts vlssgyegwy kahwigvgvk kapyfeenvg 841 gidnwydtak dtsikhnvpm irrryrketl dqewnfvrdh fgvinsiw // LOCUS NP_012466 594 aa linear PLN 30-JUN-2025 DEFINITION Utp18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012466 VERSION NP_012466.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181502.1 REFERENCE 1 (residues 1 to 594) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 594) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 594) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 594) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08730. Method: conceptual translation. FEATURES Location/Qualifiers source 1..594 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..594 /product="Utp18p" /calculated_mol_wt="66293" Region <236..592 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 251..287 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 296..347 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 350..401 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 409..448 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 473..512 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 519..556 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..594 /gene="UTP18" /locus_tag="YJL069C" /coded_by="NM_001181502.1:1..1785" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15590835|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0034388 Pwp2p-containing subcomplex of 90S preribosome [PMID:15231838|PMID:17515605]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /note="Small-subunit processome protein involved in pre-18S rRNA maturation; part of a subunit of the 90S preribosomal particle capable of interacting directly with the 5' ETS of the 35S pre-rRNA; contains WD40 repeats" /db_xref="GeneID:853376" /db_xref="SGD:S000003605" ORIGIN 1 mtmattamnv svpppdeeeq llakfvfgdt tdlqenlakf nadfifneqe mdvedqedeg 61 sesdnseede aqngeldhvn ndqlffvddg gnedsqdkne dtmdvddedd sssddyseds 121 eeaawidsdd ekikvpilvt nktkklrtsy neskingvhy inrlrsqfek iyprpkwvdd 181 esdselddee ddeeegsnnv ingdinaltk ilsttynykd tlsnskllpp kkldivrlkd 241 anashpshsa iqslsfhpsk pllltggydk tlriyhidgk tnhlvtslhl vgspiqtctf 301 ytslsnqnqq niftagrrry mhswdlslen lthsqtakie kfsrlyghes tqrsfenfkv 361 ahlqnsqtns vhgivllqgn ngwinilhst sglwlmgcki egvitdfcid yqpisrgkfr 421 tiliavnayg evwefdlnkn ghvirrwkdq ggvgitkiqv gggttttcpa lqiskikqnr 481 wlavgsesgf vnlydrnnam tsstptpvaa ldqltttisn lqfspdgqil cmasravkda 541 lrlvhlpscs vfsnwptsgt plgkvtsvaf spsggllavg neqgkvrlwk lnhy // LOCUS NP_012467 299 aa linear PLN 30-JUN-2025 DEFINITION S-formylglutathione hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012467 VERSION NP_012467.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181501.1 REFERENCE 1 (residues 1 to 299) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 299) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 299) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 299) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08731. Method: conceptual translation. FEATURES Location/Qualifiers source 1..299 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..299 /product="S-formylglutathione hydrolase" /EC_number="3.1.2.12" /calculated_mol_wt="33803" Region 2..296 /region_name="alpha/beta hydrolases" /note="A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a...; cl21494" /db_xref="CDD:473884" CDS 1..299 /locus_tag="YJL068C" /coded_by="NM_001181501.1:1..900" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10427036]" /experiment="EXISTENCE:direct assay:GO:0018738 S-formylglutathione hydrolase activity [PMID:10427036]" /experiment="EXISTENCE:mutant phenotype:GO:0046294 formaldehyde catabolic process [PMID:10427036]" /note="Esterase that can function as an S-formylglutathione hydrolase; non-essential intracellular esterase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D" /db_xref="GeneID:853377" /db_xref="SGD:S000003604" ORIGIN 1 mkvvkefsvc ggrliklshn snstktsmnv niylpkhyya qdfprnkrip tvfylsgltc 61 tpdnasekaf wqfqadkygf aivfpdtspr gdevandpeg swdfgqgagf ylnatqepya 121 qhyqmydyih kelpqtldsh fnkngdvkld fldnvaitgh smggygaicg ylkgysgkry 181 kscsafapiv npsnvpwgqk afkgylgeek aqweaydpcl liknirhvgd drilihvgds 241 dpfleehlkp ellleavkat swqdyveikk vhgfdhsyyf vstfvpehae fharnlgli // LOCUS NP_012469 252 aa linear PLN 30-JUN-2025 DEFINITION Mpm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012469 VERSION NP_012469.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181499.3 REFERENCE 1 (residues 1 to 252) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 252) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 252) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 252) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08732. On Jul 30, 2012 this sequence version replaced NP_012469.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..252 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..252 /product="Mpm1p" /calculated_mol_wt="28339" Region 70..226 /region_name="MPM1" /note="Mitochondrial peculiar membrane protein 1; pfam17234" /db_xref="CDD:435801" CDS 1..252 /gene="MPM1" /locus_tag="YJL066C" /coded_by="NM_001181499.3:1..759" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:9874242|PM ID:11791739]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289|PMID:22993211]" /note="Mitochondrial intermembrane space hypothetical protein" /db_xref="GeneID:853379" /db_xref="SGD:S000003602" ORIGIN 1 mgfyegddnd antkafndky ikdqkfatap fwnlfpklrd ideydnpllp lpfnfnfrdl 61 gdsalamasg iptvkqfdkc eelkgqsawt tqgiwkclvp skaipplpql dfllpleeik 121 sdkshshglf fndfnlflkw rshmnrlqkq riktrstave plartpedlm lnwddlhlgn 181 daeyasadgs kkivgraqsi sttkdsndak pstvktekiy fddgtvditt tttskgsspq 241 vkhkvvsvde dn // LOCUS NP_012470 167 aa linear PLN 30-JUN-2025 DEFINITION Dls1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012470 VERSION NP_012470.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181498.1 REFERENCE 1 (residues 1 to 167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 167) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08733. Method: conceptual translation. FEATURES Location/Qualifiers source 1..167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..167 /product="Dls1p" /calculated_mol_wt="18661" Region 17..106 /region_name="HFD_POLE4-like" /note="histone-fold domain found in DNA polymerase epsilon subunit 4 (POLE4) and similar proteins; cd22929" /db_xref="CDD:467054" Site order(17,24,28,31..32,34..39,41..42,44..46,48..59,80..84, 98,101..102,105) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467054" Site order(31,33,41,52,55..56,59,63,66..67,95..98,100..101, 104..105) /site_type="other" /note="catalytic subunit binding site [polypeptide binding]" /db_xref="CDD:467054" CDS 1..167 /gene="DLS1" /locus_tag="YJL065C" /coded_by="NM_001181498.1:1..504" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008623 CHRAC [PMID:15024052]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:14673157]" /experiment="EXISTENCE:mutant phenotype:GO:1903775 regulation of DNA double-strand break processing [PMID:34362907]" /note="Subunit of ISW2/yCHRAC chromatin accessibility complex; ISW2/yCHRAC also includes Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing; DLS1 has a paralog, DPB3, that arose from the whole genome duplication" /db_xref="GeneID:853381" /db_xref="SGD:S000003601" ORIGIN 1 mnnetsgket asaplcspkl pvekvqriak ndpeymdtsd dafvatafat effvqvlthe 61 slhrqqqqqq qqvpplpdel tlsyddisaa ivhssdghlq flndvipttk nlrllveenr 121 vryttsvmpp nevysayvvn dtapkpnive idldndeddd edvtdqe // LOCUS NP_012472 238 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL17m MRPL8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012472 VERSION NP_012472.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181496.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 238) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08734. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..238 /product="mitochondrial 54S ribosomal protein bL17m MRPL8" /calculated_mol_wt="26814" Region 7..127 /region_name="L17" /note="ribosomal protein L17; TIGR00059" /db_xref="CDD:272880" Region 129..238 /region_name="Mrpl_C" /note="54S ribosomal protein L8 C-terminal domain; pfam18502" /db_xref="CDD:436548" CDS 1..238 /gene="MRPL8" /locus_tag="YJL063C" /gene_synonym="bL17m; HRD238" /coded_by="NM_001181496.1:1..717" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:853382" /db_xref="SGD:S000003599" ORIGIN 1 mtvgiarkls rdkahrdall knlacqlfqh esivsthakc keasrvaeri itwtkraitt 61 snsvaqaelk sqiqsqlfla gdnrklmkrl fseiapryle rpggytrvlr leprandsap 121 qsvlelvdsp vmseshtvnr gnlkmwllvk svinddanql phnpltlqnl hkvakfkaea 181 qlhgeimlik qvllkemslp ydealenert qallkevyss slpkktkkps syvmvprp // LOCUS NP_076894 85 aa linear PLN 30-JUN-2025 DEFINITION Coa3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_076894 VERSION NP_076894.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184477.3 REFERENCE 1 (residues 1 to 85) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 85) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 85) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 85) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08735. On Jul 30, 2012 this sequence version replaced NP_076894.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..85 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..85 /product="Coa3p" /calculated_mol_wt="9750" CDS 1..85 /gene="COA3" /locus_tag="YJL062W-A" /gene_synonym="COX25; RRG10" /coded_by="NM_001184477.3:1..258" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:21068384|PMID:20876281]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:21068384|PMID:20876281]" /experiment="EXISTENCE:mutant phenotype:GO:0070130 negative regulation of mitochondrial translation [PMID:21068384|PMID:20876281]" /note="Mitochondrial protein required for cytochrome c oxidase assembly; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; located in the mitochondrial inner membrane" /db_xref="GeneID:853383" /db_xref="SGD:S000007611" ORIGIN 1 mvlnpskyqd trtwkmtpam irarkpffkg nmlgltlllg vtgsvyyyty hflhkdndfa 61 dvpippidpq elealkkeye akkka // LOCUS NP_012473 830 aa linear PLN 30-JUN-2025 DEFINITION mannose-ethanolamine phosphotransferase LAS21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012473 VERSION NP_012473.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181495.1 REFERENCE 1 (residues 1 to 830) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 830) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 830) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 830) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08736. Method: conceptual translation. FEATURES Location/Qualifiers source 1..830 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..830 /product="mannose-ethanolamine phosphotransferase LAS21" /calculated_mol_wt="94720" Region 48..343 /region_name="GPI_EPT_2" /note="GPI ethanolamine phosphate transferase 2; PIG-G; cd16024" /db_xref="CDD:293748" Site order(60..61,100,212,259..260) /site_type="active" /note="putative active site [active]" /db_xref="CDD:293748" Site order(60,100,212,260) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:293748" Region 399..820 /region_name="PIGO_PIGG" /note="GPI ethanolamine phosphate transferase membrane region; pfam19316" /db_xref="CDD:437148" CDS 1..830 /gene="LAS21" /locus_tag="YJL062W" /gene_synonym="GPI7" /coded_by="NM_001181495.1:1..2493" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10329735]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10329735]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:15452134|PMID:10329735]" /experiment="EXISTENCE:mutant phenotype:GO:0051267 CP2 mannose-ethanolamine phosphotransferase activity [PMID:15452134|PMID:10329735]" /note="Mannose-ethanolamine phosphotransferase; involved in biosynthesis of the glycosylphosphatidylinositol (GPI) core structure, catalyzing the addition of a side chain ethanolamine phosphate to the alpha1,6-linked second mannose residue of the GPI lipid precursor; integral component of endoplasmic reticulum membrane; mutations affect cell wall integrity; homolog of human PIGG" /db_xref="GeneID:853384" /db_xref="SGD:S000003598" ORIGIN 1 mnlkqftcls caqllaillf ifaffprkiv ltgiskqdpd qdrdlqrdrp fqklvfviid 61 alrsdflfds qishfnnvhq wlntgeawgy tsfanpptvt lprlksittg stpsfidlll 121 nvaqdidsnd lsehdswlqq fiqhnntirf mgddtwlklf pqqwfdfadp thsffvsdft 181 qvdnnvtrnl pgklfqewaq wdvailhylg ldhighkdgp hskfmaakhq emdsilksiy 241 devleheddd dtlicvlgdh gmnelgnhgg ssagetsagl lflspklaqf arpesqvnyt 301 lpinaspdwn fqyletvqqi divptiaalf gmpipmnsvg iiipdflqll pnklasmken 361 fmhlwklsdh hgevalddft aediytkmyt iqetltksat nynyplltla fvgfliitii 421 aiyvllrysg pdfwqlrvss lsvllvsiil gvstfassfi eeehqlwwwi vtafsavplf 481 vyrlnvliiv rwfimmacvr sikfwnnsgq kfiysnvmsn llnqnpswkw clnmltflvl 541 imasagfqvl hfivttilvg lcftykiswe ivngnqaeip lfmhdllaki dfaptesnli 601 vlarvffqaw aivvisrlvl tklkvlnkny likdmkvyit illmfqtssq nigqflvfqi 661 lesqifyffq niptasltst skiyfsnlvs lilqnftffq fggtnsisti dlgnayhgvs 721 sdyniyvvgi lmsvanfapa iywsmlpwsi nyasipaqvk lqtfirsklp aftyhcifgt 781 clmtacvvlr fhlfiwsvfs pklcyflgwn fvmgllngwl pelallcald // LOCUS NP_012474 713 aa linear PLN 30-JUN-2025 DEFINITION linker nucleoporin NUP82 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012474 VERSION NP_012474.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181494.1 REFERENCE 1 (residues 1 to 713) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 713) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 713) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 713) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08737. Method: conceptual translation. FEATURES Location/Qualifiers source 1..713 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..713 /product="linker nucleoporin NUP82" /calculated_mol_wt="81955" Region 546..>708 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" CDS 1..713 /gene="NUP82" /locus_tag="YJL061W" /gene_synonym="HRB187" /coded_by="NM_001181494.1:1..2142" /experiment="EXISTENCE:curator inference:GO:0017056 structural constituent of nuclear pore [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:7559751]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0044612 nuclear pore linkers [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:9736720|PMID:10684247]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11739405|PMID:11071906]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:11739405|PMID:10465789]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:7559750|PMID:7559751]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:15294903]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:17347149|PMID:15294903]" /note="Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup159p, and Nup116p); relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:853385" /db_xref="SGD:S000003597" ORIGIN 1 msqssrlsal pifqaslsas qspryifssq ngtrivfiqd niirwynvlt dslyhslnfs 61 rhlvlddtfh visstsgdll clfndneifv mevpwgysnv edvsiqdafq ifhysideee 121 vgpkssikkv lfhpksyrds civvlkeddt itmfdilnsq ekpivlnkpn nsfgldarvn 181 ditdlefskd gltlyclntt eggdifafyp flpsvlllne kdlnlilnks lvmyesldst 241 tdvivkrnvi kqlqfvsklh enwnsrfgkv diqkeyrlak vqgpftinpf pgelydytat 301 niatilidng qneivcvsfd dgslillfkd lemsmswdvd nyvynnslvl iervklqrei 361 kslitlpeql gklyvisdni iqqvnfmswa stlskcines dlnplaglkf esklediati 421 eripnlayin wndqsnlalm snktltfqni ssdmkpqsta aetsisteks dtvgdgfkms 481 ftqpineili lndnfqkaci spceriipsa drqiplknea senqleiftd iskeflqriv 541 kaqtlgvsih nriheqqfel trqlqstcki iskdddlrrk feaqnkkwda qlsrqselme 601 rfsklskkls qiaesnkfke kkishgemkw fkeirnqilq fnsfvhsqks lqqdlsylks 661 eltrieaeti kvdkksqnew delrkmleid skiikecnee llqvsqeftt ktq // LOCUS NP_012475 444 aa linear PLN 30-JUN-2025 DEFINITION kynurenine--oxoglutarate transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012475 VERSION NP_012475.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181493.3 REFERENCE 1 (residues 1 to 444) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 444) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 444) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 444) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08738. On Jul 30, 2012 this sequence version replaced NP_012475.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..444 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..444 /product="kynurenine--oxoglutarate transaminase" /EC_number="2.6.1.7" /calculated_mol_wt="49951" Region 52..443 /region_name="AspB" /note="Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; COG0436" /db_xref="CDD:440205" CDS 1..444 /gene="BNA3" /locus_tag="YJL060W" /coded_by="NM_001181493.3:1..1335" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:17034789]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17034789|PMID:14562095|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0016212 kynurenine-oxoglutarate transaminase activity [PMID:18205391]" /experiment="EXISTENCE:direct assay:GO:0034276 kynurenic acid biosynthetic process [PMID:18205391]" /experiment="EXISTENCE:direct assay:GO:0047536 2-aminoadipate transaminase activity [PMID:19342587]" /note="Kynurenine aminotransferase; catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate" /db_xref="GeneID:853386" /db_xref="SGD:S000003596" ORIGIN 1 mkqrfirqft nlmstsrpkv vankyftsnt akdvwsltne aaakaannsk nqgrelinlg 61 qgffsysppq faikeaqkal dipmvnqysp trgrpslins liklyspiyn telkaenvtv 121 ttganegils clmgllnagd evivfepffd qyipnielcg gkvvyvpinp pkeldqrntr 181 geewtidfeq fekaitsktk aviintphnp igkvftreel ttlgnicvkh nvviisdevy 241 ehlyftdsft riatlspeig qltltvgsag ksfaatgwri gwvlslnael lsyaakahtr 301 icfaspsplq eacansinda lkigyfekmr qeyinkfkif tsifdelglp ytapegtyfv 361 lvdfskvkip edypypeeil nkgkdfrish wlinelgvva ipptefyike hekaaenllr 421 favckddayl enaverlkll kdyl // LOCUS NP_012476 408 aa linear PLN 30-JUN-2025 DEFINITION amino acid transporter YHC3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012476 VERSION NP_012476.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181492.1 REFERENCE 1 (residues 1 to 408) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 408) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 408) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 408) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08739. Method: conceptual translation. FEATURES Location/Qualifiers source 1..408 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..408 /product="amino acid transporter YHC3" /calculated_mol_wt="46252" Region 11..396 /region_name="CLN3" /note="CLN3 protein; pfam02487" /db_xref="CDD:460570" CDS 1..408 /gene="YHC3" /locus_tag="YJL059W" /gene_synonym="BTN1" /coded_by="NM_001181492.1:1..1227" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:9753630|PMID:10319861]" /experiment="EXISTENCE:mutant phenotype:GO:0015819 lysine transport [PMID:14660799]" /experiment="EXISTENCE:mutant phenotype:GO:0051453 regulation of intracellular pH [PMID:10319861|PMID:10191121|PMID:16423829]" /experiment="EXISTENCE:mutant phenotype:GO:1903826 L-arginine transmembrane transport [PMID:14660799]" /note="Protein required for the ATP-dependent transport of arginine; vacuolar membrane protein; involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; human homolog CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) can complement yeast null mutant" /db_xref="GeneID:853387" /db_xref="SGD:S000003595" ORIGIN 1 msdkshqiyc yfwlfglinn vlyvvilsaa vdivgptlpk slvlladifp slaiklcspf 61 fidrikysyr iwslitmscl gmflvsfknl fvcllgisfa sissgfgevt flqlthyykq 121 islngwssgt ggagiiggas ymfltsifkv pvkltllvfs llpfaflfyf klesndtnlt 181 yqslqqidea eddqlvpfpv afthtnasqs lystrqhilq tvkrlrrlvf pymvplttvy 241 lfeylinqav aptllfping dersksmpff fhkyrdiyvt ygtlyqlgvf isrsfghlmr 301 mrslyilafl qgvnlcitvl qswfyvthsp wavmilifye gflggasyvn tflnileqed 361 pdetefamga vsiadsfgvf laallglgle pklcrhqiad drpwcrme // LOCUS NP_012477 543 aa linear PLN 30-JUN-2025 DEFINITION Bit61p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012477 VERSION NP_012477.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181491.1 REFERENCE 1 (residues 1 to 543) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 543) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 543) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 543) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08740. Method: conceptual translation. FEATURES Location/Qualifiers source 1..543 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..543 /product="Bit61p" /calculated_mol_wt="60710" Region 319..480 /region_name="HbrB" /note="HbrB-like; pfam08539" /db_xref="CDD:430059" CDS 1..543 /gene="BIT61" /locus_tag="YJL058C" /coded_by="NM_001181491.1:1..1632" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19144819]" /experiment="EXISTENCE:direct assay:GO:0031932 TORC2 complex [PMID:14736892]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:14736892]" /experiment="EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:14736892]" /experiment="EXISTENCE:physical interaction:GO:0031505 fungal-type cell wall organization [PMID:14736892]" /note="Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p; BIT61 has a paralog, BIT2, that arose from the whole genome duplication" /db_xref="GeneID:853388" /db_xref="SGD:S000003594" ORIGIN 1 mtaedillre rtstttqrpv nseqylnvql atapvknfqt tseisrqtlv dtsnddvysi 61 knlkgsrnpi spsvsnvgfq sifhtvdhpr skvsvasnhs lrsndnasaa tsksgssqig 121 eshsvdtvec snnlskklss daisitqksl hstpsgrymk gkasgffnrr nrahttissd 181 pasfltdsst lhnsshsfrn viknffqnks hrhigqdaie paipnslskf lhssygrhks 241 psqfihtnag qlvdsgtsvy slnvnpsgvn pntivedpls gtdpaspnpv smlhdllrnl 301 psleanykhf nsqelttltn niwnifcsnv aelfrtqriw klrakienfn evlefycilk 361 tdprvthsgm nriisdlkef lvsslynlen qivfnysned tinnalkrlg viwrifyqev 421 yydlaavllp ldqsiredgn stvlksgnes rthingnysi gflllmcfrd sivlpcyenf 481 vnsndgisks fqlyifnqee esnvtetdkl tllqcfgils tiqsndrnqr iieellagir 541 msi // LOCUS NP_012478 667 aa linear PLN 30-JUN-2025 DEFINITION protein kinase IKS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012478 VERSION NP_012478.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181490.3 REFERENCE 1 (residues 1 to 667) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 667) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 667) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 667) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08741. On Jul 30, 2012 this sequence version replaced NP_012478.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..667 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..667 /product="protein kinase IKS1" /EC_number="2.7.11.1" /calculated_mol_wt="75196" Region 173..522 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(179..183,187,203,205,237,274..277,281,283,350,352, 354..355,357,389,392) /site_type="active" /db_xref="CDD:270622" Site order(179..183,187,203,205,237,274..277,281,350,352, 354..355,357,389) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270622" Site order(183,281,283,350,352,354,392) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270622" Site 388..394 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270622" CDS 1..667 /gene="IKS1" /locus_tag="YJL057C" /coded_by="NM_001181490.3:1..2004" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894]" /note="Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p" /db_xref="GeneID:853389" /db_xref="SGD:S000003593" ORIGIN 1 mslvpyeegs lilddpnsks vvvvnptsgt lsffqqdnsn ndselnedqt aslsaldfps 61 gihqykspia syvcpqcgte inpdiinrrq lhrrasagve sessrlsipe ntvplgfefa 121 nssfsrryfq slernhrhya lqndsnnkqg qfsknkyfip ddlfipgyfr kffkilsllg 181 ngargsvykv vhtigntelg vfalkkipig ndmewfnkci revkalsslt hksanlityn 241 hvwlemdssv gfvrsidgsq sdsqeevpci filqqycsgg nledcilrkv fnrfsdtesp 301 eerkkkfrtr kknhgksgev glsteqlvsi irdiarglhe lhsiglihrd lkpsnclllt 361 pfksdnendn vydrehnsde ffpsivigdl gesqlegesr lgtgctgtle ftapdliiqg 421 rpvssstlps rsshtyneyt fasdmyslgm icyfivfgel pfepqldivd lkvriknfrf 481 dtegmiekhq amklkpidrr ifhlmdallq pnndarptak tveetldeml inskpgkkfw 541 kenvdstlnf stisevnent nsftddyidg dnvtlslpap eenlstvstq nlqkysalnr 601 tiqvcyklvs miltiiifkc tktgswlsym slillgmvfk spadergkha ralvllafia 661 ackkyiy // LOCUS NP_012479 880 aa linear PLN 30-JUN-2025 DEFINITION Zap1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012479 VERSION NP_012479.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181489.1 REFERENCE 1 (residues 1 to 880) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 880) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 880) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 880) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08742. Method: conceptual translation. FEATURES Location/Qualifiers source 1..880 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..880 /product="Zap1p" /calculated_mol_wt="98736" Region 292..761 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 743..762 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 766..>814 /region_name="SUF4-like" /note="N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; cd20908" /db_xref="CDD:411020" Region 770..795 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:411020" Region 770..790 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(775,777,779,781..782,785..786,789,803,805,809..810, 813..814,817,831,833,835,837..838,841..842,845) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Site order(775,781,788,794,797,804) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:411020" Region 798..818 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 810..834 /region_name="zf-H2C2_2" /note="Zinc-finger double domain; pfam13465" /db_xref="CDD:463886" Region 826..846 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..880 /gene="ZAP1" /locus_tag="YJL056C" /gene_synonym="ZRG10" /coded_by="NM_001181489.1:1..2643" /experiment="EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:9786867]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:22128164]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10899124]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:16720702|PMID:14517251]" /experiment="EXISTENCE:direct assay:GO:0034224 cellular response to zinc ion starvation [PMID:22128164]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22128164]" /experiment="EXISTENCE:mutant phenotype:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:9786867|PMID:12549926]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9786867|PMID:9271382]" /experiment="EXISTENCE:mutant phenotype:GO:0008270 zinc ion binding [PMID:16720702]" /experiment="EXISTENCE:mutant phenotype:GO:0034224 cellular response to zinc ion starvation [PMID:9271382|PMID:12095998|PMID:9786867]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12095998]" /note="Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains" /db_xref="GeneID:853390" /db_xref="SGD:S000003592" ORIGIN 1 mdaltprdsp krddsmatsa ataasakpda ltigkegivh ghihnynnlt yihghlhhsa 61 pvndssasat paaaavadaa tsafasgash dmggdchvne kckeytdcqh feflnyhnnp 121 sltkyndtat ynsnnhsfan nfhsvasdpt spqqnsksdl prrkdswfnd dlillpsskk 181 nkpnpppgsd dcyctpkile iccdethpks eanikqgesd qptkkdisen gndvaiftdv 241 kndhlmpnfn lhdqycnstn hdshnhnntv pdsfsqlmsh lseidcdltc dtpctastsa 301 tsghkfvqdh qssnnddvfh kyckfceest dnqpcskhmh leskppqlpp kcsslrkptn 361 tlqgtnhayh ehilntdmdl kiledlcnis slyevpfgkh inhhdhnnag ngcdgsstgn 421 nengnqtmnl llssinrcnp knnlngsnnn tagatstdhq hhhhriqfhs hkpnrnnivn 481 nsgisaantt adltnndlnd lisreysyer frnqseppsl pkvthqnqkn rrswptkdle 541 stdfssleds lpssisppiq ttstinfnwc fkeeknndlk ckwkecpesc sslfdlqrhl 601 lkdhvsqdfk hpmeplacnw edcdflgddt csivnhincq hginfdiqfa npdsflpgsi 661 skekhhllhc pnpqthevsk adgapdmtsa ndvsnippik qpeqvicqwd gcnksfssaq 721 elndhleavh ltrgkseyqc lwhdchrtfp qrqklirhlk vhskykpykc ktckrcfsse 781 etlvqhtrth sgekpykchi cnkkfaisss lkihirthtg ekplqckicg krfnessnls 841 khikthqkky kcsdcsksfd dlgklnsqkv kcalerkpyl // LOCUS NP_012480 245 aa linear PLN 30-JUN-2025 DEFINITION Log1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012480 VERSION NP_012480.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181488.1 REFERENCE 1 (residues 1 to 245) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 245) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 245) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 245) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08743. Method: conceptual translation. FEATURES Location/Qualifiers source 1..245 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..245 /product="Log1p" /calculated_mol_wt="26733" Region 19..222 /region_name="TIGR00730" /note="TIGR00730 family protein" /db_xref="CDD:129813" CDS 1..245 /gene="LOG1" /locus_tag="YJL055W" /coded_by="NM_001181488.1:1..738" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0014074 response to purine-containing compound [PMID:15932646]" /note="hypothetical protein; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA" /db_xref="GeneID:853391" /db_xref="SGD:S000003591" ORIGIN 1 mtmeknggns srggqvggks vcvycgssfg akalysesae elgalfhklg wklvygggtt 61 glmgkiarst mgpdlsgqvh giipnalvsk ertdedkedv nkallesven hkgatpisee 121 ygettivpdm htrkrmmanl sdafvampgg ygtfeeimec itwsqlgihn kpiilfnidg 181 fydklleflk hsiqerfisv kngeiiqvas tpqevvdkie kyvvpegrfn lnwsdeghah 241 edcak // LOCUS NP_012481 478 aa linear PLN 30-JUN-2025 DEFINITION Tim22-complex subunit TIM54 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012481 VERSION NP_012481.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181487.3 REFERENCE 1 (residues 1 to 478) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 478) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 478) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08744. On Jul 30, 2012 this sequence version replaced NP_012481.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..478 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..478 /product="Tim22-complex subunit TIM54" /calculated_mol_wt="54052" Region 20..466 /region_name="Tim54" /note="Inner membrane protein import complex subunit Tim54; pfam11711" /db_xref="CDD:463328" CDS 1..478 /gene="TIM54" /locus_tag="YJL054W" /coded_by="NM_001181487.3:1..1437" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:12637749]" /experiment="EXISTENCE:direct assay:GO:0042721 TIM22 mitochondrial import inner membrane insertion complex [PMID:10648604|PMID:10637294]" /experiment="EXISTENCE:genetic interaction:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:10637294|PMID:9412462]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:9412462|PMID:17893242]" /note="Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane" /db_xref="GeneID:853392" /db_xref="SGD:S000003590" ORIGIN 1 mssesgkpia kpirkpgytn palkalgipa lrlpsrnwmi fwsvltvsig giaydkykqr 61 qilshatdlv kplaeesmev dkvprkitvf iapppndyle sslkvwrryv kpvlyyagld 121 yelvqedrqg iirtnvanri relrkeilas tdgqpvkepn qtvakpsgss tskissllpf 181 nkiiqdpaee ddsfdpeigk kfkenfdwrn vigifytmpk pkhiisedal tkdpilsggv 241 iclgrgayke yiagihegll gpiektektg stepkmtgvv eanqieskvs esgatelvda 301 eketaleeak vqddlkvdee nssedsqkfl kpfissdqyp dlqiaselqt pngefirnpn 361 tnipllinqp llvipipnli gfttiprrih rfyqkrfyve dvcssvvncv rqtrirpfdi 421 akdidlakde ekdwpqnwvk qgkeknsewt qelvcdprit khmfvyekpp keepesdi // LOCUS NP_012482 379 aa linear PLN 30-JUN-2025 DEFINITION retromer subunit PEP8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012482 VERSION NP_012482.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181486.1 REFERENCE 1 (residues 1 to 379) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 379) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 379) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 379) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08745. Method: conceptual translation. FEATURES Location/Qualifiers source 1..379 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..379 /product="retromer subunit PEP8" /calculated_mol_wt="42416" Region 5..364 /region_name="Vps26" /note="Vacuolar protein sorting-associated protein 26; pfam03643" /db_xref="CDD:397622" CDS 1..379 /gene="PEP8" /locus_tag="YJL053W" /gene_synonym="GRD6; VPS26; VPT4" /coded_by="NM_001181486.1:1..1140" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0030906 retromer, cargo-selective complex [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0140318 protein transporter activity [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0140318 protein transporter activity [PMID:9700157]" /note="Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853393" /db_xref="SGD:S000003589" ORIGIN 1 msiffkppid ieilfdnees rkhvdiatrs snssyksmke slpvyedges lggivtlrvr 61 dskkvdhlgi kvsvigsidm lkshgsgnss skkvtsstss sssngsvdvr knsvdqflcq 121 sydlcpagel qhsqsfpflf rdlskryesy kgknvdvayy vkvtvmrkst diskikrfwv 181 ylynsvttap ntlsanetka ttndiaggny aadnasdntq tkstqgeaad vnqvlpishs 241 nnepkpvrld igienclhie feyaksqysl kevivgriyf lltrlrikhm elslitress 301 glqtsnvmtd stairyeimd gssvkgetip irlflsgydl tpnmscnyfn vknylslvii 361 dedgrryfkq seitlyrtr // LOCUS NP_076895 39 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL052C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_076895 VERSION NP_076895.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184476.1 REFERENCE 1 (residues 1 to 39) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 39) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 39) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 39) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08746. Method: conceptual translation. FEATURES Location/Qualifiers source 1..39 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..39 /product="uncharacterized protein" /calculated_mol_wt="4420" CDS 1..39 /locus_tag="YJL052C-A" /coded_by="NM_001184476.1:1..120" /note="hypothetical protein; identified based on comparison to related yeast species; mCherry fusion protein localizes to the vacuole" /db_xref="GeneID:853394" /db_xref="SGD:S000007610" ORIGIN 1 mhlrsrwwla llyckdpvsr sattpkvetr ascllsraf // LOCUS NP_012483 332 aa linear PLN 30-JUN-2025 DEFINITION glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012483 VERSION NP_012483.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181485.3 REFERENCE 1 (residues 1 to 332) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 332) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 332) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 332) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08747. On Jul 30, 2012 this sequence version replaced NP_012483.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..332 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..332 /product="glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1" /EC_number="1.2.1.12" /calculated_mol_wt="35619" Region 2..332 /region_name="GapA" /note="Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; COG0057" /db_xref="CDD:439827" CDS 1..332 /gene="TDH1" /locus_tag="YJL052W" /gene_synonym="GLD3" /coded_by="NM_001181485.3:1..999" /experiment="EXISTENCE:direct assay:GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [PMID:3905788]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:11158358]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11158358]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:expression pattern:GO:0006094 gluconeogenesis [PMID:3905788]" /experiment="EXISTENCE:expression pattern:GO:0006096 glycolytic process [PMID:3905788]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1; involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides secreted by S. cerevisiae are active against a wide variety of wine-related yeasts and bacteria" /db_xref="GeneID:853395" /db_xref="SGD:S000003588" ORIGIN 1 miriaingfg rigrlvlrla lqrkdievva vndpfisndy aaymvkydst hgrykgtvsh 61 ddkhiiidgv kiatyqerdp anlpwgslki dvavdstgvf keldtaqkhi dagakkvvit 121 apsssapmfv vgvnhtkytp dkkivsnasc ttnclaplak vindafgiee glmttvhsmt 181 atqktvdgps hkdwrggrta sgniipsstg aakavgkvlp elqgkltgma frvptvdvsv 241 vdltvkleke atydqikkav kaaaegpmkg vlgytedavv ssdflgdtha sifdasagiq 301 lspkfvklis wydneygysa rvvdlieyva ka // LOCUS NP_012484 822 aa linear PLN 30-JUN-2025 DEFINITION Irc8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012484 VERSION NP_012484.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181484.1 REFERENCE 1 (residues 1 to 822) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 822) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 822) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 822) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 822) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 822) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 822) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08748. Method: conceptual translation. FEATURES Location/Qualifiers source 1..822 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..822 /product="Irc8p" /calculated_mol_wt="91126" CDS 1..822 /gene="IRC8" /locus_tag="YJL051W" /coded_by="NM_001181484.1:1..2469" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /note="Bud tip localized hypothetical protein; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc" /db_xref="GeneID:853396" /db_xref="SGD:S000003587" ORIGIN 1 mchnsvrsgn kagflgikfg sallsiatga iaiallckfh dheavliviv cstllygips 61 lisfitetvf apskfhigyf ynvlnfalpl itmgctvdyf hntlrspisv qseshrvyit 121 tldslliftl fingiqlgff lkdgnannfg sssnnistdq ydkeanaven grfvplknss 181 qtltpdlell hgspksmngv awlinelstn sntnanktis sdensnssvi rhklgpists 241 kcpkkpshsh fsklkkynsf flgpkenryk rntqqatkvp tekksnhrss qyvsrlstis 301 disksflnfl alnekngnst startpsegr vsiiinegnn tlkyktphds htidspnlel 361 ereaigrins allpaclrvt dkmispqqst qnedsyqatp lipqvevddd fyvgdilmtn 421 elqdipqvpr issdieddfe qqytkhvdlp arvtlemwek dqekilqkvt tnrdkskllp 481 pfrftsesdm dpststelev elhaqnnfsf pfksaglqia tsdqfnqqef ktsdtiseld 541 eylhdpsiqe edasqliess lnqnnlsstt idngpkdmsr fstrhsptks iismisgsgs 601 vkhqhshstl snfftghsrn nsqinqllqg sssnmmsnts phssptkslr mrfgkklsls 661 nisdtmspye gsttdpinys fghghnknqs idfsyvrtlq sshsptksts gnsrrdslnn 721 drtqstvner alrtastlfy lqhnnatctl ngeepvldtp qsiqssssgs eqesagsgsg 781 ypevvfseyd rekwnvlrnl keiapektie sgpveelvsp sk // LOCUS NP_012485 1073 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase MTR4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012485 VERSION NP_012485.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181483.1 REFERENCE 1 (residues 1 to 1073) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1073) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1073) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1073) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1073) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1073) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1073) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08749. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1073 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1073 /product="ATP-dependent RNA helicase MTR4" /EC_number="3.6.4.13" /calculated_mol_wt="121924" Region 143..1068 /region_name="Dob10" /note="Superfamily II RNA helicase [Replication, recombination and repair]; COG4581" /db_xref="CDD:443638" CDS 1..1073 /gene="MTR4" /locus_tag="YJL050W" /gene_synonym="DOB1" /coded_by="NM_001181483.1:1..3222" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8756671|PMID:15226447]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16541108]" /experiment="EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:18096702]" /experiment="EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:15935758|PMID:15935759|PMID:15828860]" /experiment="EXISTENCE:direct assay:GO:0034458 3'-5' RNA helicase activity [PMID:18096702|PMID:18000032]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15935758|PMID:15828860|PMID:17643380]" /experiment="EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:11586364]" /experiment="EXISTENCE:genetic interaction:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:18000032]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10508172|PMID:9463390]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:27385342]" /experiment="EXISTENCE:mutant phenotype:GO:0016075 rRNA catabolic process [PMID:9463390|PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034458 3'-5' RNA helicase activity [PMID:18000032]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10508172|PMID:10611222]" /experiment="EXISTENCE:mutant phenotype:GO:0034476 U5 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing [PMID:17410208]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16374505|PMID:18940861]" /experiment="EXISTENCE:mutant phenotype:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:19369424]" /experiment="EXISTENCE:mutant phenotype:GO:0071051 poly(A)-dependent snoRNA 3'-end processing [PMID:10611222]" /experiment="EXISTENCE:physical interaction:GO:0031499 TRAMP complex [PMID:15935759]" /note="RNA duplex-sensing translocase; ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing" /db_xref="GeneID:853397" /db_xref="SGD:S000003586" ORIGIN 1 mdstdlfdvf eetpvelptd sngeknadtn vgdtpdhtqd kkhgleeeke eheennsenk 61 kiksnkskte dknkkvvvpv ladsfeqeas revdaskglt nsetlqveqd gkvrlshqvr 121 hqvalppnyd ytpiaehkrv neartypftl dpfqdtaisc idrgesvlvs ahtsagktvv 181 aeyaiaqslk nkqrviytsp ikalsnqkyr ellaefgdvg lmtgditinp dagclvmtte 241 ilrsmlyrgs evmrevawvi fdevhymrdk ergvvweeti illpdkvryv flsatipnam 301 efaewickih sqpchivytn frptplqhyl fpahgdgiyl vvdekstfre enfqkamasi 361 snqigddpns tdsrgkkgqt ykggsakgda kgdiykivkm iwkkkynpvi vfsfskrdce 421 elalkmskld fnsddekeal tkifnnaial lpetdrelpq ikhilpllrr gigihhsgll 481 pilkevieil fqegflkvlf atetfsigln mpaktvvfts vrkwdgqqfr wvsggeyiqm 541 sgragrrgld drgivimmid ekmepqvakg mvkgqadrld safhlgynmi lnlmrvegis 601 pefmlehsff qfqnvisvpv mekklaelkk dfdgievede envkeyheie qaikgyredv 661 rqvvthpana lsflqpgrlv eisvngkdny gwgavvdfak rinkrnpsav ytdhesyivn 721 vvvntmyids pvnllkpfnp tlpegirpae egeksicavi pitldsiksi gnlrlympkd 781 irasgqketv gkslrevnrr fpdgipvldp vknmkieded flklmkkidv lntklssnpl 841 tnsmrleely gkysrkhdlh edmkqlkrki sesqaviqld dlrrrkrvlr rlgfctpndi 901 ielkgrvace issgdelllt elifngnfne lkpeqaaall scfafqerck eaprlkpela 961 eplkamreia akiakimkds kievvekdyv esfrhelmev vyewcrgatf tqickmtdvy 1021 egslirmfkr leelvkelvd vantignssl kekmeavlkl ihrdivsags lyl // LOCUS NP_012486 450 aa linear PLN 30-JUN-2025 DEFINITION phosphatidic acid-binding protein CHM7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012486 VERSION NP_012486.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181482.3 REFERENCE 1 (residues 1 to 450) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 450) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 450) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 450) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08750. On Jul 30, 2012 this sequence version replaced NP_012486.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..450 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..450 /product="phosphatidic acid-binding protein CHM7" /calculated_mol_wt="52718" Region 247..381 /region_name="Snf7" /note="pfam03357" /db_xref="CDD:460896" CDS 1..450 /gene="CHM7" /locus_tag="YJL049W" /coded_by="NM_001181482.3:1..1353" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:33464310]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:33464310]" /experiment="EXISTENCE:mutant phenotype:GO:0051292 nuclear pore complex assembly [PMID:33464310]" /note="Phosphatidic acid (PA)-binding nuclear envelope (NE)-specific ESCRT; homolog of human CHMP7, localizes to the endoplasmic reticulum presumably as part of ESCRT-III like complex" /db_xref="GeneID:853398" /db_xref="SGD:S000003585" ORIGIN 1 mkvdlpesrl pslyrdfrpl kdlnpdgyea nistwrdffl qqyisnsnri iftigtrtlq 61 elthevygvp ksidiaidvl vnegnlipme lfnlggmytd nsrkgfwkwv rswkestnmy 121 ksrkdetnfy lredkfiika nlekeyqrfh ellkrsvfme assitdlvft rnefvttesl 181 qsffstydee tknvflhfie nykhiivskd nvikviaaev editsrfskg itendlrias 241 vkvgiinink qitrlrkein esniklrgpe fnelpkriri eykqarllse khlsrllkfq 301 nnlaqvrtqi dtsatnavli qtlsesnevi ksingyigst ekvedlldei keghdrteev 361 ndllahynkg qdeeaeeeie releqlelde knnnkeenkn qdlhepkess sedllkrlnn 421 lkintnegpv qdnenhdnei rkimmeeqpr // LOCUS NP_012487 396 aa linear PLN 30-JUN-2025 DEFINITION Ubx6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012487 VERSION NP_012487.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181481.1 REFERENCE 1 (residues 1 to 396) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 396) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 396) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 396) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08751. Method: conceptual translation. FEATURES Location/Qualifiers source 1..396 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..396 /product="Ubx6p" /calculated_mol_wt="44885" Region 190..266 /region_name="UBX" /note="Domain present in ubiquitin-regulatory proteins; smart00166" /db_xref="CDD:197552" CDS 1..396 /gene="UBX6" /locus_tag="YJL048C" /gene_synonym="CUI2" /coded_by="NM_001181481.1:1..1191" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14755638]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:14755638]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:14755638]" /note="UBX (ubiquitin regulatory X) domain-containing protein; interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline; UBX6 has a paralog, UBX7, that arose from the whole genome duplication" /db_xref="GeneID:853399" /db_xref="SGD:S000003584" ORIGIN 1 myemsgidsl fhdrvvhdys htseqvivvy issaagdnsw lhqwfkpgnl sdeerenilw 61 vrlvngtkec llfksifpss sapsinilqn gllecsiqgn slsreqdpwe tfinglqsvf 121 kgqvtkrklf sksneeyqrv krmiqndkle rkyvfqntnd pqrkpqkwkq ltvtdnvsyk 181 sqkgflaqny ctlqlklpng ytisntfppq tklhkvrmwl dyncyddgtp ylfhrniprv 241 tltrndelks lqeldllprs tlileplean nktfdymeqs sllhkvysgl tsfwakepev 301 dasssrlgyq rlgtnvsnsa nyslqklssl dmvsdggggg ggdsmtpsay ttprmypsng 361 tsqlrqnvse lnlssnnsas ntkvrtlgys nnngnn // LOCUS NP_878105 44 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL047C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878105 VERSION NP_878105.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184635.1 REFERENCE 1 (residues 1 to 44) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 44) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 44) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 44) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08752. Method: conceptual translation. FEATURES Location/Qualifiers source 1..44 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..44 /product="uncharacterized protein" /calculated_mol_wt="4918" CDS 1..44 /locus_tag="YJL047C-A" /coded_by="NM_001184635.1:1..135" /note="hypothetical protein" /db_xref="GeneID:1466468" /db_xref="SGD:S000028804" ORIGIN 1 mkikisieis lsllsehykr nencisnmlv igegprgeti verf // LOCUS NP_012488 842 aa linear PLN 30-JUN-2025 DEFINITION cullin RTT101 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012488 VERSION NP_012488.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181480.3 REFERENCE 1 (residues 1 to 842) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 842) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 842) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 842) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08753. On Jul 30, 2012 this sequence version replaced NP_012488.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..842 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..842 /product="cullin RTT101" /calculated_mol_wt="99195" Region <519..842 /region_name="COG5647" /note="Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]" /db_xref="CDD:227934" CDS 1..842 /gene="RTT101" /locus_tag="YJL047C" /gene_synonym="CUL8" /coded_by="NM_001181480.3:1..2529" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:12676951]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0035361 Cul8-RING ubiquitin ligase complex [PMID:20139071]" /experiment="EXISTENCE:mutant phenotype:GO:0007088 regulation of mitotic nuclear division [PMID:12676951]" /experiment="EXISTENCE:mutant phenotype:GO:0010526 transposable element silencing [PMID:11779788]" /experiment="EXISTENCE:mutant phenotype:GO:0031297 replication fork processing [PMID:18704118]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19390089|PMID:22505030]" /note="Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex; role in anaphase progression; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for recovery after DSB repair; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p" /db_xref="GeneID:853400" /db_xref="SGD:S000003583" ORIGIN 1 minesvskre gfhesisret sasnalglyn kfndernpry rtmiaelhef fhltlaetit 61 etdvkelecn kekaakfrkl mpkmlnncre ltqrksyipy nsefngndek qkkfqllhqh 121 qivlsfqefc delakliida hvlsfltrcd ysyeiipknw tsfyklfqyv mgavgpiisy 181 vpvnypmirk elgfetltif qyydsklfec mkshfgrefs tlvsatihhy ihmfpitntm 241 lekevpmlri msncnfsieg lspkdfymkt lrqyyceesn lrprletfkn fkvlltrnal 301 laslfspewv sdandlfish lllnkksise yieigkdtyd eekeryfkte thfsllmfrn 361 afeaknmlsk fkefcddavs eklkaaygsn hdterlfdev vqlanvdhlk iysdsieyhl 421 cnllgstska ieqyvkyfes hlfiivrkik ttkkdlprdm kikylnenlp ilrlkfvnlp 481 tfpnffersi frktilqsdq nssfikdilp vykdslmelf kqriitnvsq edemryrdqy 541 qpylsqffqp vevmadlrik yasflsfyen ieaavkfgkt ynennsksff plifdrerip 601 kvfqqsnevk knfvlpqemd dtwnqflrny heqnkvedsd askkelypmw nlhhcevesp 661 yiiqdgtnli feltlfqtcv ltlfnesdhl tlqviseqtk laykdlalvl ksfcnykilt 721 rdidntysin esfkpdmkkv kngklrvvlp rtaslqssnt ggertssahh egsnsqwtqe 781 llkacitrsv kserngldyd hlfetvkqqi kgfsvgefkd alakllrdkf itrdestaty 841 ky // LOCUS NP_012489 409 aa linear PLN 30-JUN-2025 DEFINITION putative lipoate--protein ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012489 VERSION NP_012489.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181479.1 REFERENCE 1 (residues 1 to 409) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 409) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 409) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 409) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08754. On Dec 12, 2005 this sequence version replaced NP_012489.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..409 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..409 /product="putative lipoate--protein ligase" /EC_number="6.3.1.20" /calculated_mol_wt="46872" Region 117..409 /region_name="BPL_LplA_LipB" /note="biotin-lipoate ligase family; cl14057" /db_xref="CDD:449326" Site order(155,188,193..197,201,203,240,249..253,265..267,269) /site_type="active" /db_xref="CDD:319742" CDS 1..409 /gene="AIM22" /locus_tag="YJL046W" /gene_synonym="LIP3; RRG3" /coded_by="NM_001181479.1:1..1230" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19570983]" /experiment="EXISTENCE:mutant phenotype:GO:0009249 protein lipoylation [PMID:19570983]" /note="Lipoate-protein ligase; octanoyl-CoA: protein transferase required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss" /db_xref="GeneID:853401" /db_xref="SGD:S000003582" ORIGIN 1 msmmlsnwal spryvgqrnl ihcttlfhtl trwakdaddk yhdinsmyen mftpsndnvs 61 ilqdegksdy dttkassmee disafnkdly nfynigyakq imsasqleni vkakgrfviq 121 slstspyynl alenyvfknt prakrgpdnc rllfyindrc avigknqnlw qevdlaklks 181 knfellrrfs gggtvlhdlg nvnysyltsr ekfetkffnk miikwlnsln pelrldlner 241 gdiiqdgfki sgsaykiagg kayhhatmll nadleqfsgl lepslpnnme wessgvhsvk 301 skiknvgiit pnqfiavvse rfqktfkvdg eipiyycdef ksindeikda mntlqseqwk 361 yfsgpkfsvk ikdkgltikv ekgmiydcdr ndliglefkg flenidsyt // LOCUS NP_012490 634 aa linear PLN 30-JUN-2025 DEFINITION succinate dehydrogenase SDH9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012490 VERSION NP_012490.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181478.1 REFERENCE 1 (residues 1 to 634) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 634) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 634) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 634) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 634) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 634) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 634) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08755. Method: conceptual translation. FEATURES Location/Qualifiers source 1..634 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..634 /product="succinate dehydrogenase SDH9" /EC_number="1.3.5.1" /calculated_mol_wt="69252" Region 5..634 /region_name="FAD_binding_2" /note="FAD binding domain; cl46878" /db_xref="CDD:481218" CDS 1..634 /gene="SDH9" /locus_tag="YJL045W" /coded_by="NM_001181478.1:1..1905" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:16232921|PMID:9730279]" /experiment="EXISTENCE:genetic interaction:GO:0045333 cellular respiration [PMID:9730279|PMID:16232921]" /experiment="EXISTENCE:mutant phenotype:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:16232921]" /experiment="EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:16232921]" /note="Minor succinate dehydrogenase isozyme; participates in oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner; YJL045W has a paralog, SDH1, that arose from the whole genome duplication" /db_xref="GeneID:853405" /db_xref="SGD:S000003581" ORIGIN 1 mlslkkgitk syilqrtfts ssvvrqigev kseskppaky hiidheydcv vvgaggaglr 61 aafglaeagy ktaclsklfp trshtvaaqg ginaalgnmh pddwkshmyd tvkgsdwlgd 121 qdaihymtre apksvieleh ygmpfsrted griyqrafgg qskdfgkggq ayrtcavadr 181 tghamlhtly gqalknnthf fieyfamdll thngevvgvi aynqedgtih rfrahktvia 241 tggygrayfs ctsahtctgd gnamvsragf pledlefvqf hpsgiygsgc litegargeg 301 gfllnseger fmeryaptak dlasrdvvsr aitmeiragr gvgknkdhil lqlshlppev 361 lkerlpgise taavfagvdv tqepipvlpt vhynmggipt kwtgealtid eetgedkvip 421 glmacgeaac vsvhganrlg anslldlvvf gravantiad tlqpglphkp lasnighesi 481 anldkvrnar gslktsqirl nmqrtmqkdv svfrtqdtld egvrnitevd ktfedvhvsd 541 ksmiwnsdlv etlelqnllt catqtavsas krkesrgaha redyakrddv nwrkhtlswq 601 kgtstpvkik yrnviahtld enecapvppa vrsy // LOCUS NP_012491 458 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein GYP6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012491 VERSION NP_012491.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181477.3 REFERENCE 1 (residues 1 to 458) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 458) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 458) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 458) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08756. On Jul 30, 2012 this sequence version replaced NP_012491.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..458 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..458 /product="GTPase-activating protein GYP6" /calculated_mol_wt="53684" Region <145..336 /region_name="TBC" /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; smart00164" /db_xref="CDD:214540" CDS 1..458 /gene="GYP6" /locus_tag="YJL044C" /coded_by="NM_001181477.3:1..1377" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:8441469]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:35134079]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14610088]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:24924636]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0090630 activation of GTPase activity [PMID:8441469]" /note="GTPase-activating protein (GAP) for yeast Rab family member Ypt6p; involved in vesicle mediated protein transport" /db_xref="GeneID:853406" /db_xref="SGD:S000003580" ORIGIN 1 mkdvlqwaid hyetrdqlvq kgiwkgelyh dsifkensrg wlwkalllcd ennnclltdn 61 fkgldlnqfg lvpvpmladg dnydenhnan vpkrvlhsnv sssvgirrlt pveavekhpl 121 sddndktkgs lskgsdekpl tlretleiid ldlsrimldd ifqepkvhaq mrqllynyll 181 ihqsehlqyk qgfheilsvi ylqlyhgtdl dntdlqnvli ifnklmnqie pifyneenli 241 nwdkrvftki friclpdlfs kvfyqppktg sgkkknvdhl ihsnliwlir wtrllflrel 301 plkyvlivwd hvltfnypld ifiactiitl llsiydelhe lvsqgdyeht nnndefveli 361 lhfkkifeke daskddekfl dlckvtgnlc elwygknydd mrlicdtfin akfgiktsdv 421 lsmetaklti dpnrqslenk lrervrqtil knkkkisq // LOCUS NP_012492 257 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL043W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012492 VERSION NP_012492.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181476.1 REFERENCE 1 (residues 1 to 257) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 257) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 257) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 257) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08757. Method: conceptual translation. FEATURES Location/Qualifiers source 1..257 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..257 /product="uncharacterized protein" /calculated_mol_wt="29107" CDS 1..257 /locus_tag="YJL043W" /coded_by="NM_001181476.1:1..774" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="hypothetical protein; YJL043W is a non-essential gene" /db_xref="GeneID:853407" /db_xref="SGD:S000003579" ORIGIN 1 mfvdysgler ytdinasfgk lvntyccfqr ceaiseqlei lkslvpkchd ivaltdedfa 61 sgrtagltqk lfamamtlhq itdcidllqk cntiipieia npasfesgaa taplrqsyar 121 llddwshymg pstvkhtgct nrpkwrfpwq qsrtiiipml figetamstr dlrsvlhdce 181 irhasemplq llwtsspelv yatphvddyd iwsrygsdyn mqiededeas kgrqrkcvvq 241 leallgalpt tdplfqw // LOCUS NP_012493 1398 aa linear PLN 30-JUN-2025 DEFINITION Mhp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012493 VERSION NP_012493.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181475.1 REFERENCE 1 (residues 1 to 1398) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1398) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1398) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1398) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08758. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1398 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1398 /product="Mhp1p" /calculated_mol_wt="155077" Region <832..1015 /region_name="PPP1R42" /note="protein phosphatase 1 regulatory subunit 42; cl42388" /db_xref="CDD:455733" CDS 1..1398 /gene="MHP1" /locus_tag="YJL042W" /coded_by="NM_001181475.1:1..4197" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:9855114]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:8947554]" /experiment="EXISTENCE:mutant phenotype:GO:0007026 negative regulation of microtubule depolymerization [PMID:9855114]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:9090049]" /note="Microtubule-associated protein involved in microtubule organization; involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins" /db_xref="GeneID:853408" /db_xref="SGD:S000003578" ORIGIN 1 mdskdtqkll kehripcidv gwlvrpsast skssrpgkse skansvapdi qmdtarppvf 61 etsvdssssi lssndkgrrh svaasllmdn qranagstsv ptnippprgr sksvvetnls 121 nveadsghhh hhrhhhhted apapkkvgff kslfghrkkd qeqqekerer kerspspthv 181 drgaairrer tatisaespp plqynappsy ndtvvpltrs ktesevyyen hpqsyyhgrm 241 rtyhspeegk vdgtspaddh nyggsrpdpr lmdflryyks kdyklaafke gnfikssasp 301 ttkknrrasf slhndkpqpa kslahqkfda kgrpipphpd apklpsafrk khpsnasivd 361 tvdsnsdvss saqnnnqtps shkfgaflrk vtsygnnnnn stnasslsan vnnpdtssts 421 lwssssmefd pskittvpgl enirplkhvs fatntyfndp pqqicsknpr kgevevkpng 481 svvihrltpq erkkimests lgvvvggtgq lkllnpeedd anakskeema pqkqneveah 541 deednnsqrr nivmaaaeaa aearakeapn elkrivtnne eevtvsktas hltidkpmis 601 rrgastssla smvssdtngt naddegeilp ppslkiphdi vytrcchlre ilpipatlkq 661 lkkgstdpip ilqlrnprps mveiwsfsdf lsiapvlcls ldgvqltvqm lriilsslvy 721 kqhfqklslr ntpldeegwk vlcyfvskak slhsidltmv psiktnvqkp sksslkskil 781 rmqcnlenrs dmnwdlltas ialmggleei visgakmnsa qfknfilvac iaterlglay 841 nglsksqcdd lakwmvqskv tgldvgfndl ngklssftda vlgkiqkane knvfkflsln 901 gtnlrvnehd tfennevlkl isvlcylenl kfldisnnpa ifphcvptli dflpvfvnlv 961 rlhidynnls stsvvmlaei lpmcsrlnyf smlgteldla sskalaeavr kssslmtldv 1021 dyvympenik ekislyalrn iqgelkrvns ddkdikdsqf sslqdqlsll ltekadnseh 1081 ynkmvenfma kialarikis kvvhdlfdlk lngqlnlegk ealirlcfie aslergcdll 1141 kqrhnntlks peavsksrkg gnqaqpnses cqrmllsssi lqnsdhialm pfgsaiveks 1201 spdaedavef regddsnvnh edvpandqqf rdevdiknky siikrelehe klvgggdlpv 1261 dkeilnraaq sldsdqikef llkndvstil gvidelhsqg yhlhhifkkq gnqeetafrt 1321 kdeqqssqsn dssanasptt dpistgsnts rtndnahipp tdapgfdkfm nnaeenaida 1381 ayddvldkiq darnsstk // LOCUS NP_012494 823 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin NSP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012494 VERSION NP_012494.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181474.3 REFERENCE 1 (residues 1 to 823) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 823) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 823) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 823) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 823) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 823) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 823) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08759. On Jul 30, 2012 this sequence version replaced NP_012494.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..823 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..823 /product="FG-nucleoporin NSP1" /calculated_mol_wt="86385" Region 61..>214 /region_name="PHA03255" /note="BDLF3; Provisional" /db_xref="CDD:165513" Region <289..>602 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" Region 620..731 /region_name="Nsp1_C" /note="Nsp1-like C-terminal region; pfam05064" /db_xref="CDD:461540" CDS 1..823 /gene="NSP1" /locus_tag="YJL041W" /coded_by="NM_001181474.3:1..2472" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17897934]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:2112428]" /experiment="EXISTENCE:direct assay:GO:0017056 structural constituent of nuclear pore [PMID:19098896|PMID:19680227]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406|PMID:9813081|PMID:24574455]" /experiment="EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:9813081]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]" /experiment="EXISTENCE:genetic interaction:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:10952996]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906|PMID:9971735|PMID:11739405]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:11739405]" /experiment="EXISTENCE:mutant phenotype:GO:0006405 RNA export from nucleus [PMID:11352936]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:8524308]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220|PMID:2112428]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:19098896|PMID:17418788|PMID:12169684]" /note="FG-nucleoporin component of central core of the nuclear pore complex; also part of the nuclear pore complex (NPC) nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p)" /db_xref="GeneID:853409" /db_xref="SGD:S000003577" ORIGIN 1 mnfntpqqnk tpfsfgtann nsnttnqnss tgagafgtgq stfgfnnsap nntnnanssi 61 tpafgsnntg ntafgnsnpt snvfgsnnst tntfgsnsag tslfgsssaq qtksngtagg 121 ntfgssslfn nstnsnttkp afgglnfggg nnttpsstgn antsnnlfga tanankpafs 181 fgattnddkk tepdkpafsf nssvgnktda qapttgfsfg sqlggnktvn eaakpslsfg 241 sgsaganpag asqpepttne pakpalsfgt atsdnkttnt tpsfsfgaks denkagatsk 301 pafsfgakpe ekkddnsskp afsfgaksne dkqdgtakpa fsfgakpaek nnnetskpaf 361 sfgaksdekk dgdaskpafs fgakpdenka satskpafsf gakpeekkdd nsskpafsfg 421 aksnedkqdg takpafsfga kpaeknnnet skpafsfgak sdekkdgdas kpafsfgaks 481 dekkdsdssk pafsfgtksn ekkdsgsskp afsfgakpde kkndevskpa fsfgakanek 541 kesdesksaf sfgskptgke egdgakaais fgakpeeqks sdtskpaftf gaqkdnekkt 601 eesstgksta dvkssdslkl nskpvelkpv sldnktlddl vtkwtnqlte sashfeqytk 661 kinswdqvlv kggeqisqly sdavmaehsq nkidqslqyi erqqdelenf ldnfetktea 721 llsdvvstss gaaannndqk rqqayktaqt ldenlnslss nlsslivein nvsntfnktt 781 nidinneden iqlikilnsh fdalrslddn stslekqins ikk // LOCUS NP_012495 1683 aa linear PLN 30-JUN-2025 DEFINITION Nup192p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012495 VERSION NP_012495.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181473.1 REFERENCE 1 (residues 1 to 1683) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1683) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1683) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1683) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08760. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1683 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1683 /product="Nup192p" /calculated_mol_wt="191405" Region 134..1677 /region_name="Nup192" /note="Nuclear pore complex scaffold, nucleoporins 186/192/205; pfam11894" /db_xref="CDD:463387" CDS 1..1683 /gene="NUP192" /locus_tag="YJL039C" /coded_by="NM_001181473.1:1..5052" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0044611 nuclear pore inner ring [PMID:18046406]" /experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:10428845|PMID:11121302]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:10428845]" /experiment="EXISTENCE:mutant phenotype:GO:0046822 regulation of nucleocytoplasmic transport [PMID:23499021]" /note="Essential subunit of inner ring of nuclear pore complex (NPC); plays a role in modulating transport through the NPC; homologous to human NUP205" /db_xref="GeneID:853410" /db_xref="SGD:S000003576" ORIGIN 1 mkwsaipfqt lyrsiesgef dfdlfkevlp dlqnlnlntd klknnasrsq lekgeielsd 61 gstfkvnqef ifeaislsde lnldeivace lilsgdttan ngkvqyflrr qyilqivsfi 121 vncfhedtel yqelikngal vsnilsafkf ihtqlseikq qinkaqilen ynalfqqnik 181 frrdfllrey dilsqilygl vdkgaimknk dfilsllhhv seldsndffi iyytpaffhl 241 faslrvlpda dvkllhsqfm kdlkddsiyt kpvkvalifi ffayfigwck edpkrradtm 301 dfktdvdepm tsavelgaie qilifaadts iveqdksmel fydirsller hiprlipkql 361 lddekifsqt tnstynpasa tdnmsgrglw npsypgmmst tgtarlnsmp nnvneysytt 421 ivlsdqtqef flssfddvlq tiitdcafll tkikdaeeds llsgedltld dislkadler 481 fflsiyffya srpeysctfw sdkesnaygf iewcsrcndn lmrscfylmv sslsfgpena 541 lnvyhyfgen ssiswkniaq clsdytkkis nfnsslhkrq qfsesthndi dstavaleeg 601 lneeavifls slltlvgsvt yqvdedvkss lskvfsdvlf eftkintplv gaafkvisnl 661 vpklessrtk fwsfldslif kdsslnysse syrnaftnvl tkysdvlgfl qlfhnlisih 721 srennseymv fgklafptrl gqgyrkvgiw pyfdyifndi lahvdqivdi rnkravqlpi 781 lkiiytglcs fdysvilnsi paaanldalv dcenffnyvq ecpaipifny iftekiyksi 841 fnvvdvgvdq lsieleggkn qaellqlavk iinkvldyqe tyveelfpiv kkhgktdyfl 901 pknyslhglr sfydaiffni plvahlglyv gvddqilatn slrilaklse rsngsvasls 961 krnklltifd svdesarikd afitqlessi tdagvlalkl elldfltsnl snysrtmtis 1021 hlllgfqvsn vislgpnlat fissgtslld slisvleasl nsitkdnidy apmrlataal 1081 eiilklcrnp ltsgllysyl ikenfferim ildpqvtrft twngspfdns teekcknfie 1141 sesvgaflsf layrnywtqy lglfihkisf sgtksevlty vnylisntmy svrlfsfldp 1201 lnygnicepk etlsiftnvp lnleqvtlnk ycsgniydfh kmenlmrlik rvraeslhsn 1261 sfsltvskeq flkdadveci kakshftnii srnkalelnl svlhswvqlv qiivtdgkle 1321 pstrsnfile vfgtiipkis dyiefnitfs eelvslavfl fdiynrdrkl itdkgtvdgr 1381 lyqlfktciq ginsplssva lrsdfyilan hylsrvlsdq vgsekvlqdl rlgskklvei 1441 iwndvvygeg tsrvtgilll dsliqlanrs kenfildslm kttrllliir slkntdalln 1501 sttehinidd llyeltafka tvfflirvae trggasalie nnlfriiael sflkvdpdlg 1561 ldlmfdevyv qnskflkvnv tldnpllvdk dangvslfel ivpifqlisa vlvsmgssnk 1621 avvqtvkgll ntykrlvigi fkrdllreke dkknssdpnn qslnemvkli vmlctltgyq 1681 nnd // LOCUS NP_012496 219 aa linear PLN 30-JUN-2025 DEFINITION Loh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012496 VERSION NP_012496.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181472.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 219) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08761. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..219 /product="Loh1p" /calculated_mol_wt="24712" CDS 1..219 /gene="LOH1" /locus_tag="YJL038C" /gene_synonym="OSW4" /coded_by="NM_001181472.1:1..660" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18562670]" /note="Protein involved in outer spore wall assembly; likely involved directly in dityrosine layer assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to adjacent ORF, IRC18/YJL037W, and the irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to the single mutants; SWAT-GFP and mCherry fusion proteins localize to the cytosol; proposed role in maintenance of genome integrity" /db_xref="GeneID:853413" /db_xref="SGD:S000003575" ORIGIN 1 mrfqlfiyfy ftivviagtn tiqqfsdagd rlitslrnld nngtyetlta ekvpiiegqi 61 qnisakyeqh tfilkgleav lnykvksldn neresleiey ekvekaldaa lnvspfeyik 121 kfkevsrgkv vnalenlsre qnritinggr edekekeare kkkrldrikr iltvsllelg 181 laqgvadlca vapfacllgv tvgsigfifw laliynaiq // LOCUS NP_012497 224 aa linear PLN 30-JUN-2025 DEFINITION Irc18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012497 VERSION NP_012497.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181471.3 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 224) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08762. On Jul 30, 2012 this sequence version replaced NP_012497.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..224 /product="Irc18p" /calculated_mol_wt="24615" CDS 1..224 /gene="IRC18" /locus_tag="YJL037W" /gene_synonym="OSW6" /coded_by="NM_001181471.3:1..675" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]" /note="Protein involved in outer spore wall assembly; possible role in assembly of the dityrosine layer; similar to adjacent ORF, LOH1; irc18 loh1 double mutant exhibits reduced dityrosine fluorescence relative to single mutants; SWAT-GFP fusion protein localizes to the ER and vacuole, while mCherry fusion localizes to the vacuole; expression induced in respiratory-deficient cells and carbon-limited chemostat culture; null mutant displays increased levels of spontaneous Rad52p foci" /db_xref="GeneID:853414" /db_xref="SGD:S000003574" ORIGIN 1 mkvqmierif liqlclltvv lassravvef estgtklvns lrvlaaysqs svcvdekisg 61 ierqieevkd mygnhsfilk glngilnnkv nmltreiqme tvgnntfete tgkltkglnr 121 avnispfkyi kkfktvstkk fesllnkydl vakkggelte eqkkkkevls risrvvaatt 181 ieaglaqgvv dlcitvttsl clvsasiggv gfliwltiiy qalt // LOCUS NP_012498 423 aa linear PLN 30-JUN-2025 DEFINITION Snx4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012498 VERSION NP_012498.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181470.1 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 423) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08763. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..423 /product="Snx4p" /calculated_mol_wt="48871" Region 1..423 /region_name="COG5391" /note="Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]" /db_xref="CDD:227680" CDS 1..423 /gene="SNX4" /locus_tag="YJL036W" /gene_synonym="ATG24; CVT13" /coded_by="NM_001181470.1:1..1272" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:12048214|PMID:18497569]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:17420293]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12048214|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:12554655|PMID:11557775]" /experiment="EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:33678121]" /experiment="EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:12554655]" /experiment="EXISTENCE:genetic interaction:GO:0036010 protein localization to endosome [PMID:29511122]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12554655]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:38832010]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:12048214|PMID:12554655]" /experiment="EXISTENCE:mutant phenotype:GO:0032456 endocytic recycling [PMID:32074001]" /experiment="EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:12554655]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0061723 glycophagy [PMID:38832010]" /experiment="EXISTENCE:physical interaction:GO:0034498 early endosome to Golgi transport [PMID:12554655]" /note="Sorting nexin; involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p" /db_xref="GeneID:853416" /db_xref="SGD:S000003573" ORIGIN 1 mtdkgkndlt skakdkargn pekppywfei ivsdpqkrtg dpgsssgyvs yqistktnnt 61 sfydnrgdpe siivvhrrys dllllhdill nrfptciipp lpdkkvfqyi agdrfsqrft 121 qkrchslqnf lrrvslhpdl sqskvfktfl vskdweshrk vlqdslqpnk devtdafmna 181 fktvhkqnee fteireksdk ldrtvtkidk lfhkvvkknd smsedytklg snlqelqelv 241 tgeneelaak lkifnegvtq lsyglqdltk yldyeyivdl kdlehyidsm rqliklkdqk 301 qidyeelsdy ltrsikeknn lisgyggsnf fankleelag inqeasrrek inklegkits 361 ltgelenakk vadgfeqecl keidhfesvk taeikkslgs ladhhiefye rileawekvd 421 dsl // LOCUS NP_012499 250 aa linear PLN 30-JUN-2025 DEFINITION tRNA(adenine34) deaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012499 VERSION NP_012499.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181469.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 250) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08764. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..250 /product="tRNA(adenine34) deaminase" /EC_number="3.5.4.33" /calculated_mol_wt="28121" Region 7..120 /region_name="nucleoside_deaminase" /note="Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; cd01285" /db_xref="CDD:238612" Site order(25,43,54..56,88,91) /site_type="active" /note="nucleoside/Zn binding site [active]" /db_xref="CDD:238612" Site order(52,57,61,89..90,93..94,97..98) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238612" Site order(54..56,87..88,91) /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:238612" CDS 1..250 /gene="TAD2" /locus_tag="YJL035C" /coded_by="NM_001181469.1:1..753" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:10550050]" /experiment="EXISTENCE:direct assay:GO:0008251 tRNA-specific adenosine deaminase activity [PMID:10550050]" /note="Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs" /db_xref="GeneID:853417" /db_xref="SGD:S000003572" ORIGIN 1 mqhikhmrta vrlaryaldh detpvacifv htptgqvmay gmndtnkslt gvahaefmgi 61 dqikamlgsr gvvdvfkdit lyvtvepcim casalkqldi gkvvfgcgne rfggngtvls 121 vnhdtctlvp knnsaagyes ipgilrkeai mllryfyvrq nerapkprsk sdrvldkntf 181 ppmewskyln eeafietfgd dyrtcfankv dlssnsvdwd lidshqdnii qeleeqckmf 241 kfnvhkkskv // LOCUS NP_012500 682 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family ATPase KAR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012500 VERSION NP_012500.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181468.3 REFERENCE 1 (residues 1 to 682) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 682) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 682) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 682) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08765. On Jul 30, 2012 this sequence version replaced NP_012500.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..682 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..682 /product="Hsp70 family ATPase KAR2" /EC_number="3.6.4.10" /calculated_mol_wt="74337" Region 52..654 /region_name="HSP70" /note="Hsp70 protein; pfam00012" /db_xref="CDD:394970" CDS 1..682 /gene="KAR2" /locus_tag="YJL034W" /gene_synonym="GRP78" /coded_by="NM_001181468.3:1..2049" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:2661018]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:1325440]" /experiment="EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:10367885]" /experiment="EXISTENCE:direct assay:GO:0034099 luminal surveillance complex [PMID:16873065]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:23704572]" /experiment="EXISTENCE:genetic interaction:GO:0070880 fungal-type cell wall beta-glucan biosynthetic process [PMID:9430631]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:10069807]" /experiment="EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:7568189]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:12808051]" /experiment="EXISTENCE:mutant phenotype:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7568189]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11381090]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:12808051]" /experiment="EXISTENCE:mutant phenotype:GO:0070972 protein localization to endoplasmic reticulum [PMID:1996357]" /note="ATPase involved in protein import into the ER; also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p" /db_xref="GeneID:853418" /db_xref="SGD:S000003571" ORIGIN 1 mffnrlsagk llvplsvvly alfvvilplq nsfhssnvlv rgaddvenyg tvigidlgtt 61 yscvavmkng kteilaneqg nritpsyvaf tdderligda aknqvaanpq ntifdikrli 121 glkyndrsvq kdikhlpfnv vnkdgkpave vsvkgekkvf tpeeisgmil gkmkqiaedy 181 lgtkvthavv tvpayfndaq rqatkdagti aglnvlrivn eptaaaiayg ldksdkehqi 241 ivydlgggtf dvsllsieng vfevqatsgd thlggedfdy kivrqlikaf kkkhgidvsd 301 nnkalaklkr eaekakrals sqmstrieid sfvdgidlse tltrakfeel nldlfkktlk 361 pvekvlqdsg lekkdvddiv lvggstripk vqqllesyfd gkkaskginp deavaygaav 421 qagvlsgeeg vedivlldvn altlgiettg gvmtplikrn taiptkksqi fstavdnqpt 481 vmikvyeger amskdnnllg kfeltgippa prgvpqievt faldangilk vsatdkgtgk 541 sesititndk grltqeeidr mveeaekfas edasikakve srnklenyah slknqvngdl 601 gekleeedke tlldaandvl ewlddnfeta iaedfdekfe slskvaypit sklyggadgs 661 gaadyddede dddgdyfehd el // LOCUS NP_012501 770 aa linear PLN 30-JUN-2025 DEFINITION RNA-dependent ATPase HCA4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012501 VERSION NP_012501.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181467.1 REFERENCE 1 (residues 1 to 770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 770) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08766. Method: conceptual translation. FEATURES Location/Qualifiers source 1..770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..770 /product="RNA-dependent ATPase HCA4" /EC_number="3.6.4.13" /calculated_mol_wt="87062" Region 52..249 /region_name="DEADc_DDX10" /note="DEAD-box helicase domain of DEAD box protein 10; cd17941" /db_xref="CDD:350699" Site order(61,63,65,68,86..93,195) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350699" Region 266..397 /region_name="SF2_C_DEAD" /note="C-terminal helicase domain of the DEAD box helicases; cd18787" /db_xref="CDD:350174" Site order(356,358,383,386..387) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350174" Region 431..488 /region_name="DUF4217" /note="Domain of unknown function (DUF4217); pfam13959" /db_xref="CDD:464056" CDS 1..770 /gene="HCA4" /locus_tag="YJL033W" /gene_synonym="DBP4; ECM24" /coded_by="NM_001181467.1:1..2313" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23153376]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:18975973|PMID:23153376]" /experiment="EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:16209945]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:16209945]" /experiment="EXISTENCE:mutant phenotype:GO:0032040 small-subunit processome [PMID:24357410]" /note="DEAD box RNA helicase; component of the SSU; interacts with Bfr2p and Enp2p; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis" /db_xref="GeneID:853419" /db_xref="SGD:S000003570" ORIGIN 1 makknrlntt qrktlrqked eyienlktki deydpkitka kffkdlpisd ptlkglress 61 fiklteiqad sipvslqghd vlaaaktgsg ktlaflvpvi eklyrekwte fdglgaliis 121 ptrelamqiy evltkigsht sfsaglvigg kdvkfeleri sriniligtp grilqhldqa 181 vglntsnlqm lvldeadrcl dmgfkktlda ivstlspsrq tllfsatqsq svadlarlsl 241 tdyktvgthd vmdgsvnkea stpetlqqfy ievpladkld ilfsfikshl kckmivflss 301 skqvhfvyet frkmqpgisl mhlhgrqkqr artetldkfn raqqvclfat dvvargidfp 361 avdwvvqvdc pedvdtyihr vgrcarygkk gkslimltpq eqeaflkrln arkiepgkln 421 ikqskkksik pqlqsllfkd pelkylgqka fisyvrsiyv qkdkqvfkfd elpteefays 481 lglpgapkik mkgmktieqa kerknaprql aflskanedg eviedkskqp rtkydkmfer 541 knqtilsehy lnitkaqaqe dedddfisvk rkdheineae lpaltlptsr raqkkalskk 601 aslaskgnas klifddegea hpvyeledee efhkrgdaev qktefltkes avmadidnid 661 kqvakekkqe kkrkrleamr remeaameee isgdeeegkt vaylgtgnls ddmsdgdmpd 721 seghlkkkar tvdyshghnp snsvdddiie veepqtledl esltakliqg // LOCUS NP_012503 327 aa linear PLN 30-JUN-2025 DEFINITION Rab geranylgeranyltransferase BET4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012503 VERSION NP_012503.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181465.1 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 327) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08767. On Feb 2, 2004 this sequence version replaced NP_012503.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..327 /product="Rab geranylgeranyltransferase BET4" /EC_number="2.5.1.60" /calculated_mol_wt="39544" Region 1..327 /region_name="BET4" /note="Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]; COG5536" /db_xref="CDD:227823" CDS 1..327 /gene="BET4" /locus_tag="YJL031C" /coded_by="NM_001181465.1:1..984" /experiment="EXISTENCE:direct assay:GO:0004663 Rab geranylgeranyltransferase activity [PMID:8756702]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27663510]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005968 Rab-protein geranylgeranyltransferase complex [PMID:8756702]" /experiment="EXISTENCE:direct assay:GO:0018344 protein geranylgeranylation [PMID:8756702]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:8232541]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8232541]" /experiment="EXISTENCE:mutant phenotype:GO:0018344 protein geranylgeranylation [PMID:8232541]" /experiment="EXISTENCE:physical interaction:GO:0005968 Rab-protein geranylgeranyltransferase complex [PMID:8232542]" /note="Alpha subunit of Type II geranylgeranyltransferase; required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p" /db_xref="GeneID:853421" /db_xref="SGD:S000003568" ORIGIN 1 mhgikrkqwt kellrqkrvq dekkiydyrs ltenvlnmrd ekiysiealk ktselleknp 61 efnaiwnyrr diiaslasel eipfwdkelv fvmmllkdyp kvywiwnhrl wvlkhyptss 121 pkvwqtelav vnklleqdar nyhgwhyrri vvgniesitn ksldkeefey ttikinnnis 181 nysawhqrvq iisrmfqkge vgnqkeyirt eisyiinamf tdaedqsvwf yikwfikndi 241 vcktldeqey lkmlkdlren illinndeie fsgkqniwcl killvledil eekealters 301 seqylvqlid adplrknryl hlleqhk // LOCUS NP_012504 196 aa linear PLN 30-JUN-2025 DEFINITION spindle checkpoint protein MAD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012504 VERSION NP_012504.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181464.3 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 196) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08768. On Jul 30, 2012 this sequence version replaced NP_012504.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..196 /product="spindle checkpoint protein MAD2" /calculated_mol_wt="22153" Region 10..186 /region_name="HORMA" /note="HORMA domain; pfam02301" /db_xref="CDD:460526" CDS 1..196 /gene="MAD2" /locus_tag="YJL030W" /coded_by="NM_001181464.3:1..591" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:27170178]" /experiment="EXISTENCE:direct assay:GO:0033597 mitotic checkpoint complex [PMID:11726501]" /experiment="EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:22940250]" /experiment="EXISTENCE:genetic interaction:GO:0044774 mitotic DNA integrity checkpoint signaling [PMID:16651657]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:10704439]" /experiment="EXISTENCE:physical interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:9461437]" /experiment="EXISTENCE:physical interaction:GO:0033597 mitotic checkpoint complex [PMID:10704439|PMID:11726501]" /note="Component of the spindle-assembly checkpoint complex; delays onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I; gene dosage imbalance between MAD1 and MAD2 leads to chromosome instability" /db_xref="GeneID:853422" /db_xref="SGD:S000003567" ORIGIN 1 msqsislkgs trtvteffey sinsilyqrg vypaedfvtv kkydltllkt hddelkdyir 61 killqvhrwl lggkcnqlvl civdkdegev verwsfnvqh isgnsngqdd vvdlnttqsq 121 iralirqits svtflpeltk eggytftvla ytdadakvpl ewadsnskei pdgevvqfkt 181 fstndhkvga qvsyky // LOCUS NP_012505 822 aa linear PLN 30-JUN-2025 DEFINITION Vps53p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012505 VERSION NP_012505.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181463.1 REFERENCE 1 (residues 1 to 822) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 822) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 822) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 822) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 822) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 822) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 822) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08769. Method: conceptual translation. FEATURES Location/Qualifiers source 1..822 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..822 /product="Vps53p" /calculated_mol_wt="95318" Region 6..368 /region_name="Vps53_N" /note="Vps53-like, N-terminal; pfam04100" /db_xref="CDD:427710" Region 575..779 /region_name="VPS53_C" /note="Vacuolar protein sorting-associated protein 53 C-terminus; pfam16854" /db_xref="CDD:407097" CDS 1..822 /gene="VPS53" /locus_tag="YJL029C" /coded_by="NM_001181463.1:1..2469" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:10637310]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042147 retrograde transport, endosome to Golgi [PMID:12686613]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:10637310]" /experiment="EXISTENCE:mutant phenotype:GO:0090156 intracellular sphingolipid homeostasis [PMID:26357016]" /experiment="EXISTENCE:physical interaction:GO:0000938 GARP complex [PMID:10637310]" /note="Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; required for vacuolar protein sorting; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p; human ortholog is implicated in progressive cerebello-cerebral atrophy type 2 (PCCA2)" /db_xref="GeneID:853423" /db_xref="SGD:S000003566" ORIGIN 1 mlegtvdydp leditnilfs keslnnidel isitrsykkq lqedilkeen elkehpknsa 61 eieaslrkvf qdfketqdvs asteltisnl tegisyldia kknlthsltl fqnlkiltds 121 yiqcnellsq gsfkkmvspy kimcslaent fisyksldei nyllssisrl kgdtlskikq 181 nynalfsggn isehdtaltm elregacell dcdtstraqm idwcldkllf emkeifrvdd 241 eagslenlsr ryiyfkkiln nfnskfadyf lkdwemavrl tttfyhithk dlqtllkref 301 kdknpsidlf mtalqstldf ekyidvrfsk kikepklssc fepyltlwvs hqnqmmekkf 361 lsymsepkyp sneteslvlp ssadlfrtyr svltqtleli dnnandsilt slanffsrwl 421 qtysqkillp lllpdnievq dkleaakytv llintadyca ttidqledkl sefsgnrekl 481 ansftktkni yddllakgts fllnrvipld lnfvwrefin ndwsnaaied ysrymvtlks 541 vlkmpaltda sikqqqeqps tlafilsqfn rdvykwnfld kvidiittnf vsntirllqp 601 vppfslagsk rkfetrtvvn igeqllldle llkeifhtlp esvsndsdlr entsykrvkr 661 hadnnidqll kfikllmapl dsaddyyety skltnnnpds avwsfvlalk gipwdlalwk 721 klwsaynlet ddtdegsrpd snrdlfifkw dkvllgqfen nlarmqdpnw skfvrqdlki 781 sppvmkrivs tpqiqqqkee qkkqslsvkd fvshsrffnr gt // LOCUS NP_012506 111 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL028W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012506 VERSION NP_012506.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181462.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 111) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08770. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..111 /product="uncharacterized protein" /calculated_mol_wt="12766" CDS 1..111 /locus_tag="YJL028W" /coded_by="NM_001181462.1:1..336" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments" /db_xref="GeneID:853425" /db_xref="SGD:S000003565" ORIGIN 1 malwgrsayr qktvtsrltk hrhtsplnll nffiffslhl calflatavh yacfacfvlf 61 rhailllfyl largrasqiq arqkvrctga tfyrfliisl sqrawatkkp i // LOCUS NP_012507 138 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL027C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012507 VERSION NP_012507.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181461.3 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 138) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08771. On Jul 30, 2012 this sequence version replaced NP_012507.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..138 /product="uncharacterized protein" /calculated_mol_wt="15583" CDS 1..138 /locus_tag="YJL027C" /coded_by="NM_001181461.3:1..417" /note="hypothetical protein" /db_xref="GeneID:853426" /db_xref="SGD:S000003564" ORIGIN 1 mmvtrkhyry iylqnshsli scfvhfefpr vwygaicpcf psfallrkif fcqqqqhatl 61 cavlrsglcg ngdivpmpar revwvwgvcd lvamaiargc glspngcpll rishscrvnk 121 khergrtaln sgrsrdvk // LOCUS NP_012508 399 aa linear PLN 30-JUN-2025 DEFINITION ribonucleotide-diphosphate reductase subunit RNR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012508 VERSION NP_012508.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181460.1 REFERENCE 1 (residues 1 to 399) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 399) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 399) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 399) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08772. Method: conceptual translation. FEATURES Location/Qualifiers source 1..399 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..399 /product="ribonucleotide-diphosphate reductase subunit RNR2" /EC_number="1.17.4.1" /calculated_mol_wt="46016" Region 76..399 /region_name="Ferritin_like" /note="Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; cl00264" /db_xref="CDD:469698" Site order(97,104,170..171,174,177..178,181,184,201..202,205) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153108" Site order(108,145,176,179,183,271..272,276) /site_type="active" /note="putative radical transfer pathway [active]" /db_xref="CDD:153108" Site order(145,176,179,239,273,276) /site_type="other" /note="diiron center [ion binding]" /db_xref="CDD:153108" Site 183 /site_type="other" /note="tyrosyl radical" /db_xref="CDD:153108" CDS 1..399 /gene="RNR2" /locus_tag="YJL026W" /gene_synonym="CRT6" /coded_by="NM_001181460.1:1..1200" /experiment="EXISTENCE:direct assay:GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor [PMID:10716984|PMID:10535923]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12732713]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9315670|PMID:12732713]" /experiment="EXISTENCE:direct assay:GO:0005971 ribonucleoside-diphosphate reductase complex [PMID:10716984]" /experiment="EXISTENCE:direct assay:GO:0009263 deoxyribonucleotide biosynthetic process [PMID:10535923|PMID:5459124]" /note="Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits; RNR2 has a paralog, RNR4, that arose from the whole genome duplication" /db_xref="GeneID:853427" /db_xref="SGD:S000003563" ORIGIN 1 mpketpskaa adalsdleik dsksnlnkel etlreenrvk sdmlkeklsk daenhkaylk 61 shqvhrhklk emekeeplln edkertvlfp ikyheiwqay kraeasfwta eeidlskdih 121 dwnnrmnene rffisrvlaf faasdgivne nlvenfstev qipeaksfyg fqimienihs 181 etysllidty ikdpkesefl fnaihtipei gekaewalrw iqdadalfge rlvafasieg 241 vffsgsfasi fwlkkrgmmp gltfsnelic rdeglhtdfa cllfahlknk pdpaivekiv 301 teaveieqry fldalpvall gmnadlmnqy vefvadrllv afgnkkyykv enpfdfmeni 361 slagktnffe krvsdyqkag vmskstkqea gaftfnedf // LOCUS NP_012509 514 aa linear PLN 30-JUN-2025 DEFINITION Rrn7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012509 VERSION NP_012509.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181459.1 REFERENCE 1 (residues 1 to 514) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 514) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 514) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 514) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08773. Method: conceptual translation. FEATURES Location/Qualifiers source 1..514 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..514 /product="Rrn7p" /calculated_mol_wt="60226" Region 4..37 /region_name="zf-RRN7" /note="Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7; pfam11781" /db_xref="CDD:463348" Region 363..>399 /region_name="SAM_superfamily" /note="SAM (Sterile alpha motif); cl15755" /db_xref="CDD:472832" CDS 1..514 /gene="RRN7" /locus_tag="YJL025W" /coded_by="NM_001181459.1:1..1545" /experiment="EXISTENCE:direct assay:GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding [PMID:18451108]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22362748]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:8702872]" /experiment="EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:7958901]" /experiment="EXISTENCE:direct assay:GO:0070860 RNA polymerase I core factor complex [PMID:7958901|PMID:8702872|PMID:8887672]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:7958901]" /experiment="EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:8702872]" /note="Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p" /db_xref="GeneID:853428" /db_xref="SGD:S000003562" ORIGIN 1 mstfirgpic gtdncpsrlw riidgrrtcq yghvmegdve fnddeddlng lgagvitrrl 61 nlttnatgsf qssqltnsql lqqqqrqshk kfkklighea kllflksfqf ilkrqirwli 121 temrfpkefe hvakiiwlki lktindqpqe elklqlhmts tisilylast hlslpvytcd 181 yikwictakm pyfqaseilp kswriqlpny yvsilegsis pfngqlynki altcgmihfk 241 effnseiscq glllklvmqc alppefyfyt kqviefeetd irnltlwert derhtgrvsn 301 haelrvlsyf mltinwmlsf drdrqyplkw ilsltesltq rtttsesigr nivkvvypdk 361 ptssdyfqws eeetleflkw mekqflptqt kslhnengsm emtidqkiar rklykifpld 421 reanhdgefn dsthqltfie dlqeryakqt pffesnkird slnyqeanpp arkeaigrll 481 thiasqllvd faiskeqlkd cisriknacl hrmn // LOCUS NP_012510 194 aa linear PLN 30-JUN-2025 DEFINITION Aps3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012510 VERSION NP_012510.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181458.3 REFERENCE 1 (residues 1 to 194) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 194) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 194) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 194) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08774. On Jul 30, 2012 this sequence version replaced NP_012510.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..194 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..194 /product="Aps3p" /calculated_mol_wt="21807" Region 1..172 /region_name="APS2" /note="Clathrin adaptor complex, small subunit [Intracellular trafficking and secretion]; COG5030" /db_xref="CDD:227363" CDS 1..194 /gene="APS3" /locus_tag="YJL024C" /gene_synonym="YKS7" /coded_by="NM_001181458.3:1..585" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:17895371]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:9335339]" /experiment="EXISTENCE:mutant phenotype:GO:0030123 AP-3 adaptor complex [PMID:9250663]" /note="Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853429" /db_xref="SGD:S000003561" ORIGIN 1 mihavlifnk kcqprlvkfy tpvdlpkqkl lleqvyelis qrnsdfqssf lvtppsllls 61 nennndevnn ediqiiykny atlyftfivd dqeselaild liqtfvesld rcftevneld 121 lifnwqtles vleeivqggm vietnvnriv asvdelnkaa estdskigrl tstgfgsalq 181 afaqggfaqw atgq // LOCUS NP_012511 347 aa linear PLN 30-JUN-2025 DEFINITION Pet130p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012511 VERSION NP_012511.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181457.1 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 347) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08775. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..347 /product="Pet130p" /calculated_mol_wt="39682" CDS 1..347 /gene="PET130" /locus_tag="YJL023C" /coded_by="NM_001181457.1:1..1044" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0099617 matrix side of mitochondrial inner membrane [PMID:30759361]" /experiment="EXISTENCE:mutant phenotype:GO:0097745 mitochondrial tRNA 5'-end processing [PMID:30759361]" /note="hypothetical protein; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; localizes to the matrix side of the inner mitochondrial membrane" /db_xref="GeneID:853432" /db_xref="SGD:S000003560" ORIGIN 1 mkifstllsq kpkgklvirp sttihssdpf skfivtknte plslgdlrks dsgnsavcln 61 aentilstlt dlqkeeernw dpvkfvagkl rgvispiqay vtigkkfspn slvytsrffq 121 lhyfpedhfm scfrkskpai tvksnkkfyl ngkvfnkdke yfnetriska nevelskiqt 181 amtrltnrhr nsipsefayl rrdlklkvkt tfikewckln gdkaireyvn lnrspninpa 241 smkgkpkksf ldnlgrstvg takdgyylyi vsifpdkdml gefndevnrs vqkvanldwd 301 gfltpkkgtk gknwvesfnd sinvqtinki leinkfpfel rreqteg // LOCUS NP_012514 1157 aa linear PLN 30-JUN-2025 DEFINITION Bbc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012514 VERSION NP_012514.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181454.1 REFERENCE 1 (residues 1 to 1157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1157) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08776. On Jul 9, 2001 this sequence version replaced NP_012514.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1157 /product="Bbc1p" /calculated_mol_wt="128166" Region 7..66 /region_name="SH3_Bbc1" /note="Src Homology 3 domain of Bbc1 and similar domains; cd11887" /db_xref="CDD:212820" Site order(14,16,19,23,41..42,60,62..63) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212820" Region <212..>425 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" CDS 1..1157 /gene="BBC1" /locus_tag="YJL020C" /gene_synonym="MTI1; YJL021C" /coded_by="NM_001181454.1:1..3474" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:16824951|PMID:11743162]" /experiment="EXISTENCE:direct assay:GO:0032032 myosin I tail binding [PMID:11901111]" /experiment="EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:12814545]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:11901111]" /experiment="EXISTENCE:physical interaction:GO:0032032 myosin I tail binding [PMID:11901111]" /note="Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches" /db_xref="GeneID:853433" /db_xref="SGD:S000003557" ORIGIN 1 msepevpfkv vaqfpyksdy eddlnfekdq eiivtsveda ewyfgeyqds ngdviegifp 61 ksfvavqgse vgkeaesspn tgsteqrtiq peveqkdlpe pispetkket lsgpvpvpaa 121 tvpvpaatvp vpaatavsaq vqhdsssgng erkvpmdspk lkarlsmfnq diteqvplpk 181 sthldlenip vkktivadap kyyvppgipt ndtsnlerkk slkenekkiv pepinraqve 241 sgrietendq lkkdlpqmsl keriallqeq qrlqaareee llrkkakleq ehersavnkn 301 epyteteeae enektepkpe ftpetehnee pqmellahke itktsreade gtndiekeqf 361 ldeytkenqk veesqadear genvaeesei gyghedregd ndeekeeeds eenrraalre 421 rmaklsgasr fgapvgfnpf gmasgvgnkp seepkkkqhk ekeeeepeql qelpraipvm 481 pfvdpssnpf frksnlsekn qptetktldp hatteheqkq ehgthayhnl aavdnahpey 541 sdhdsdedtd dhefedandg lrkhsmveqa fqignnesen vnsgekiypq eppishrtae 601 vshdienssq nttgnvlpvs spqtrvarng sinsltksis genrrksine yhdtvstnss 661 altetaqdis maapaapvls kvshpedkvp phpvpsapsa ppvpsapsvp sappvppapp 721 alsapsvppv ppvppvssap palsapsipp vpptppappa ppaplalpkh neveehvkss 781 aplppvseey hpmpntappl prappvppat fefdseptat hshtapsppp hqnvtastps 841 mmstqqrvpt svlsgaekes rtlpphvpsl tnrpvdsfhe sdttpkvasi rrstthdvge 901 isnnvkiefn aqerwwinks appaisnlkl nflmeiddhf iskrlhqkwv vrdfyflfen 961 ysqlrfsltf nstspektvt tlqerfpspv etqsarilde yaqrfnakvv ekshslinsh 1021 igaknfvsqi vsefkdeviq pigartfgat ilsykpeegi eqlmkslqki kpgdilvirk 1081 akfeahkkig kneiinvgmd saapyssvvt dydftknkfr vienhegkii qnsyklshmk 1141 sgklkvfriv argyvgw // LOCUS NP_012515 682 aa linear PLN 30-JUN-2025 DEFINITION Mps3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012515 VERSION NP_012515.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181453.3 REFERENCE 1 (residues 1 to 682) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 682) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 682) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 682) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 682) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08777. On Jul 30, 2012 this sequence version replaced NP_012515.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..682 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..682 /product="Mps3p" /calculated_mol_wt="79044" Region 478..615 /region_name="Sad1_UNC" /note="Sad1 / UNC-like C-terminal; cl23730" /db_xref="CDD:474037" CDS 1..682 /gene="MPS3" /locus_tag="YJL019W" /gene_synonym="NEP98; YJL018W" /coded_by="NM_001181453.3:1..2049" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:17495028]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:17495028]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:16923827]" /experiment="EXISTENCE:direct assay:GO:0005825 half bridge of spindle pole body [PMID:12486115]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:12493774|PMID:12486115]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:18039933|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0007129 homologous chromosome pairing at meiosis [PMID:17495028]" /experiment="EXISTENCE:genetic interaction:GO:0045141 meiotic telomere clustering [PMID:17495028]" /experiment="EXISTENCE:mutant phenotype:GO:0000741 karyogamy [PMID:16923827]" /experiment="EXISTENCE:mutant phenotype:GO:0000743 nuclear migration involved in conjugation with cellular fusion [PMID:12493774]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:15355977]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:17495028]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:16923827|PMID:12486115]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:22593213]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:22593213]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:18039933|PMID:22593213]" /experiment="EXISTENCE:mutant phenotype:GO:0045141 meiotic telomere clustering [PMID:17495028]" /note="Nuclear envelope protein; required for SPB insertion, SPB duplication, Kar5p localization near the SPB and nuclear fusion; interacts with Mps2p to tether half-bridge to core SPB; N-terminal acetylation by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; member of the SUN protein family (Sad1-UNC-84 homology)" /db_xref="GeneID:853434" /db_xref="SGD:S000003556" ORIGIN 1 mnnsnehrre eagaaneqmp ynkavksaya dvlkdkmnre qeislraikk giytdggetd 61 nydmdkends ayemfkknld fpldqhnddd dddpyiedng qetdgysded ytdeadksfi 121 edsdsdsydl esnsdfeenl essgeakklk wrtyifyggl ffvfyffgsf lmttvknndl 181 eshssgatss pgksfsnlqk qvnhlysels krdekhssel dktvkiivsq feknikrllp 241 snlvnfendi nsltkqveti stsmselqrr nhkftvenvt qwqdqlvkql dthlpqeipv 301 vinnssslli ipelhnylsa lisdviespg igtagsaesr weydlnryvk eilsnelqyi 361 dkdyfiqemn rrlqsnkqei weeitnrlet qqqqqqqqvq qdysnvpqqy ssilmkrlih 421 qiynsnqhqw eddldfatyv qgtkllnhlt sptwrqgsgv qpielltdsk qssstywqce 481 nepgcswair fktplyltki symhgrftnn lhimnsaprl islyvklsqt keikalqtla 541 nqygfgqhhk rdrnyikiak feyrltdsri rqqmylppwf iqlkplvrsi vfqvdenygn 601 kkfislrkfi ingvtpqdlq iiennefpvl lgdtpeygvt qntdegkrkv llskppyass 661 ststkfhpas nvpsfgqdel dq // LOCUS NP_012518 561 aa linear PLN 30-JUN-2025 DEFINITION Tph3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012518 VERSION NP_012518.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181450.1 REFERENCE 1 (residues 1 to 561) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 561) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 561) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 561) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08778. On Oct 2, 2003 this sequence version replaced NP_012518.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..561 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..561 /product="Tph3p" /calculated_mol_wt="63076" CDS 1..561 /gene="TPH3" /locus_tag="YJL016W" /gene_synonym="YJL017W" /coded_by="NM_001181450.1:1..1686" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; GFP-fusion protein localizes to the cytoplasm; contains two adjacent PH-like domains; conserved in closely related Saccharomyces species" /db_xref="GeneID:853436" /db_xref="SGD:S000003553" ORIGIN 1 mgildslkkp vniksslpkf srsatsinls shpvssrsfl elppelfsit kpifkllqah 61 ankiyfqssd aeavwnvkds sghvfeaesi sllgshiiit nssvqvadva iidspsninq 121 ceissvgefl qfnngqlsit cndfgllekf krlcmisife fisiykaltg tvissyglrm 181 sdmhiilnsp fnfkdwcevy ldgqgwvkvw chidkvsktn nsksssdnda kgkyqirfyr 241 ddkstssknc vffipdneyv qdiffynina aepsknmndf fqglqmiklv gnvrfcsdtd 301 fndvvdsgsi yssanngsgd ssstalnnes pnttpksrtf fspkghrrns shvssltsrs 361 tkkpitnftt rtngllirpl phhgvhhlea mirfiiplmd carlygrpvq fktertdins 421 lmfglpklps vdyfaeeeia hlmtqefnpl kekdtddtma ltmsrfssyl qermtkvskr 481 ntelnfrtfs dvmgmynttr dhsklncmsd kdnsvkefsl sdksnvsset tnmmnqlqvn 541 aheykssmce rpivastspi a // LOCUS NP_012520 534 aa linear PLN 30-JUN-2025 DEFINITION chaperonin-containing T-complex subunit CCT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012520 VERSION NP_012520.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181448.1 REFERENCE 1 (residues 1 to 534) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 534) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 534) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 534) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08779. Method: conceptual translation. FEATURES Location/Qualifiers source 1..534 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..534 /product="chaperonin-containing T-complex subunit CCT3" /calculated_mol_wt="58683" Region 4..533 /region_name="chap_CCT_gamma" /note="T-complex protein 1, gamma subunit; TIGR02344" /db_xref="CDD:274085" CDS 1..534 /gene="CCT3" /locus_tag="YJL014W" /gene_synonym="BIN2; TCP3" /coded_by="NM_001181448.1:1..1605" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo; capable of binding Q/N rich proteins and mediating their folding" /db_xref="GeneID:853438" /db_xref="SGD:S000003551" ORIGIN 1 mqapvvfmna sqerttgrqa qisnitaaka vadvirtclg pkamlkmlld pmgglvltnd 61 ghailreidv ahpaaksmle lsrtqdeevg dgtttviila geilaqcapy lieknihpvi 121 iiqalkkalt dalevikqvs kpvdvendaa mkkliqasig tkyvihwsek mcelaldavk 181 tvrkdlgqtv egepnfeidi kryvrvekip ggdvldsrvl kgvllnkdvv hpkmsrhien 241 prvvlldcpl eykkgesqtn ieiekeedwn rilqieeeqv qlmceqilav rptlvitekg 301 vsdlaqhyll kggcsvlrrv kksdnnriar vtgativnrv edlkesdvgt ncglfkvemi 361 gdeyfsfldn ckepkactim lrggskdiln eidrnlqdam avarnvmlsp slspgggate 421 mavsvklaek akqlegiqqw pyqavadame ciprtliqna ggdpirllsq lrakhaqgnf 481 ttgidgdkgk ivdmvsygiw epevikqqsv ktaiesacll lrvddivsgv rkqe // LOCUS NP_012521 515 aa linear PLN 30-JUN-2025 DEFINITION Mad3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012521 VERSION NP_012521.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181447.3 REFERENCE 1 (residues 1 to 515) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 515) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 515) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 515) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08780. On Jul 30, 2012 this sequence version replaced NP_012521.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..515 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..515 /product="Mad3p" /calculated_mol_wt="59390" Region 57..188 /region_name="Mad3_BUB1_I" /note="Mad3/BUB1 hoMad3/BUB1 homology region 1; smart00777" /db_xref="CDD:214817" Region 330..397 /region_name="Mad3_BUB1_II" /note="Mad3/BUB1 homology region 2; pfam08171" /db_xref="CDD:400476" CDS 1..515 /gene="MAD3" /locus_tag="YJL013C" /coded_by="NM_001181447.3:1..1548" /experiment="EXISTENCE:direct assay:GO:0033597 mitotic checkpoint complex [PMID:11726501]" /experiment="EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:22940250]" /experiment="EXISTENCE:genetic interaction:GO:0044774 mitotic DNA integrity checkpoint signaling [PMID:16651657]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:10704439]" /experiment="EXISTENCE:mutant phenotype:GO:0032837 distributive segregation [PMID:15951820]" /experiment="EXISTENCE:mutant phenotype:GO:0033597 mitotic checkpoint complex [PMID:10704439]" /experiment="EXISTENCE:physical interaction:GO:0033597 mitotic checkpoint complex [PMID:10704439|PMID:11726501]" /note="Subunit of spindle-assembly checkpoint complex; involved in delaying anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover; MAD3 has a paralog, BUB1, that arose from the whole genome duplication" /db_xref="GeneID:853439" /db_xref="SGD:S000003550" ORIGIN 1 mkayakkris ympsspsqnv infeeietqk enilplkegr saaalskaih qplveinqvk 61 ssfeqrlide lpalsdpitl yleyikwlnn aypqggnskq sgmltllerc lshlkdlery 121 rndvrflkiw fwyielftrn sfmesrdifm ymlrngigse lasfyeeftn lliqkekfqy 181 avkilqlgik nkarpnkvle drlnhllrel genniqlgne ismdslestv lgktrsefvn 241 rlelanqngt ssdvnltknn vfvdgeesdv elfetpnrgv yrdgwenfdl kaernkennl 301 rislleantn lgelkqheml sqkkrpydek lpifrdsigr sdpvyqmint kdqkpekidc 361 nfkliycede eskggrlefs leevlaisrn vykrvrtnrk hpreanlgqe esanqkeaea 421 qskrpkisrk alvsksltps nqgrmfsgee yincpmtpkg rstetsdiis avkprqltpi 481 lemresnsfs qsknseiisd ddkssssfis yppqr // LOCUS NP_012522 721 aa linear PLN 30-JUN-2025 DEFINITION Vtc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012522 VERSION NP_012522.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181446.1 REFERENCE 1 (residues 1 to 721) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 721) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 721) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 721) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 721) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 721) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 721) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08781. On Feb 23, 2004 this sequence version replaced NP_012522.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..721 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..721 /product="Vtc4p" /EC_number="2.7.4.1" /calculated_mol_wt="83024" Region 2..136 /region_name="SPX_VTC2_like" /note="SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; cd14480" /db_xref="CDD:269901" Region 191..478 /region_name="PolyPPase_VTC4_like" /note="Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) protein VTC4, and similar proteins; cd07751" /db_xref="CDD:143623" Site order(195,197,255,258,285..289,435..437,442,446,476) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:143623" Site order(196,200,241,264,266,281,294,359,361,377,426,428, 456..459) /site_type="active" /db_xref="CDD:143623" Site order(196,426,428) /site_type="other" /note="putative metal binding residues [ion binding]" /db_xref="CDD:143623" Site order(196,198,200) /site_type="active" /note="signature motif [active]" /db_xref="CDD:143623" Site order(200,241,253,256,264,266,281,283,291..292,294,359,361, 373,426,428,455..459) /site_type="active" /note="polyP binding site [active]" /db_xref="CDD:143623" Site order(200,241,264,266,281,294,359,361,377,426,456..458) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:143623" Site order(241,264,281,457..459) /site_type="active" /note="acceptor-phosphate pocket [active]" /db_xref="CDD:143623" Region 593..721 /region_name="DUF202" /note="Domain of unknown function (DUF202); cl09954" /db_xref="CDD:447870" CDS 1..721 /gene="VTC4" /locus_tag="YJL012C" /gene_synonym="PHM3; YJL012C-A" /coded_by="NM_001181446.1:1..2166" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000822 inositol hexakisphosphate binding [PMID:27080106]" /experiment="EXISTENCE:direct assay:GO:0005516 calmodulin binding [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:12584253]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0008976 polyphosphate kinase activity [PMID:19390046]" /experiment="EXISTENCE:direct assay:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:11102525|PMID:19390046]" /experiment="EXISTENCE:mutant phenotype:GO:0006799 polyphosphate biosynthetic process [PMID:27252384|PMID:27080106]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:physical interaction:GO:0033254 vacuolar transporter chaperone complex [PMID:11823419]" /note="Vacuolar membrane polyphosphate polymerase; subunit of vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853441" /db_xref="SGD:S000003549" ORIGIN 1 mkfgehlsks lirqysyyyi syddlktele dnlsknngqw tqeletdfle sleieldkvy 61 tfckvkhsev frrvkevqeq vqhtvrllds nnpptqldfe ileeelsdii advhdlakfs 121 rlnytgfqki ikkhdkktgf ilkpvfqvrl dskpffkeny delvvkisql ydiartsgrp 181 ikgdssaggk qqnfvrqttk ywvhpdnite lkliilkhlp vlvfntnkef eredsaitsi 241 yfdnenldly ygrlrkdega eahrlrwygg mstdtifver kthredwtge ksvkarfalk 301 erhvndflkg kytvdqvfak mrkegkkpmn eienlealas eiqyvmlkkk lrpvvrsfyn 361 rtafqlpgda rvrisldtel tmvrednfdg vdrthknwrr tdigvdwpfk qlddkdicrf 421 pyavlevklq tqlgqeppew vrelvgshlv epvpkfskfi hgvatllndk vdsipfwlpq 481 mdvdirkppl ptnieitrpg rsdnedndfd eddeddaalv aamtnapgns ldieesvgyg 541 atsaptsntn hvvesanaay yqrkirnaen piskkyyeiv affdhyfngd qiskipkgtt 601 fdtqirappg kticvpvrve pkvyfatert ylswlsisil lggvsttllt ygsptamigs 661 igffitslav lirtvmvyak rvvnirlkra vdyedkigpg mvsvflilsi lfsffcnlva 721 k // LOCUS NP_012523 161 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase III subunit RPC17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012523 VERSION NP_012523.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181445.2 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 161) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08782. On Apr 26, 2011 this sequence version replaced NP_012523.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..161 /product="DNA-directed RNA polymerase III subunit RPC17" /calculated_mol_wt="18465" Region 10..160 /region_name="RNA_pol_Rpb4" /note="RNA polymerase Rpb4; pfam03874" /db_xref="CDD:461080" CDS 1..161 /gene="RPC17" /locus_tag="YJL011C" /coded_by="NM_001181445.2:1..486" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:10611227|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:10611227]" /experiment="EXISTENCE:physical interaction:GO:0006384 transcription initiation at RNA polymerase III promoter [PMID:10611227]" /note="RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:853442" /db_xref="SGD:S000003548" ORIGIN 1 mkvleernaf lsdyevlkfl tdlekkhlwd qkslaalkks rskgkqnrpy nhpelqgitr 61 nvvnylsink nfinqedege eressgakda eksgiskmsd esfaelmtkl nsfklfkaek 121 lqivnqlpan mvhlysivee cdarfdekti eemleiisgy a // LOCUS NP_012524 666 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding RNA processing protein NOP9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012524 VERSION NP_012524.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181444.3 REFERENCE 1 (residues 1 to 666) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 666) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 666) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 666) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 666) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08783. On Jul 30, 2012 this sequence version replaced NP_012524.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..666 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..666 /product="RNA-binding RNA processing protein NOP9" /calculated_mol_wt="77591" Region <89..205 /region_name="Pumilio" /note="Pumilio-family RNA binding domain; cl46378" /db_xref="CDD:480718" Region <341..571 /region_name="Pumilio" /note="Pumilio-family RNA binding domain; cl46378" /db_xref="CDD:480718" CDS 1..666 /gene="NOP9" /locus_tag="YJL010C" /coded_by="NM_001181444.3:1..2001" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:17956976]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:17956976|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:17956976]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:17956976]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:17956976]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17956976]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17956976]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17956976]" /note="Essential subunit of U3-containing 90S preribosome; involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain" /db_xref="GeneID:853445" /db_xref="SGD:S000003547" ORIGIN 1 mgktktrgrr hqdkqrkdef epssnsakeh iqqeestynd eaeiketqpq mffgvldree 61 leyfkqaest lqldafeape ekfqfvtsii eeakgkelkl vtsqitsklm ervilecdet 121 qlkdifqsfn gvffglschk yashvletlf vrsaalvere lltpsfdnne kegpyvtmen 181 mflfmlnelk phlktmmnhq yashvlrlli lilssktlpn stkanstlrs kkskiarkmi 241 dikdnddfnk vyqtpesfks elrdiittly kgftngaesr sdisqstitk freysvdkva 301 spviqliiqv egifdrdrsf wrlvfntade kdpkeesfle yllsdpvgsh flenvigsar 361 lkyverlyrl ymkdrivkla krdttgafvv rallehlkek dvkqildavv pelsmllnsn 421 mdfgtaiina snkqggylrd dviaqliqky ypeksdakni lesclllsas tlgntrddwp 481 taeerrrsvf leqlidyddk flnitidsml alpeerliqm cyhgvfshvv ehvlqttrvd 541 iikrkmllni lskesvnlac nvygshimdk lweftakltl ykeriaralv letekvknsi 601 ygrqvwknwk lelyvrkmwd wkklikeqef eifpnskplq pkpekhsrer nnskegsafk 661 kqkhyr // LOCUS NP_012526 568 aa linear PLN 30-JUN-2025 DEFINITION chaperonin-containing T-complex subunit CCT8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012526 VERSION NP_012526.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181442.2 REFERENCE 1 (residues 1 to 568) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 568) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 568) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 568) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08784. Method: conceptual translation. FEATURES Location/Qualifiers source 1..568 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..568 /product="chaperonin-containing T-complex subunit CCT8" /calculated_mol_wt="61531" Region 9..559 /region_name="chap_CCT_theta" /note="T-complex protein 1, theta subunit; TIGR02346" /db_xref="CDD:274087" Site order(19,23,51..54,56,74,76,80,84,87,391,540..546) /site_type="other" /note="ring oligomerisation interface [polypeptide binding]" /db_xref="CDD:239457" Site order(46..48,98,102,165,403,423,463,517,519) /site_type="other" /note="ATP/Mg binding site [chemical binding]" /db_xref="CDD:239457" Site order(443,461,470,472..473,476) /site_type="active" /note="stacking interactions [active]" /db_xref="CDD:239457" CDS 1..568 /gene="CCT8" /locus_tag="YJL008C" /coded_by="NM_001181442.2:1..1707" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo" /db_xref="GeneID:853447" /db_xref="SGD:S000003545" ORIGIN 1 mslrlpqnpn aglfkqgyns ysnadgqiik siaairelhq mcltsmgpcg rnkiivnhlg 61 kiiitndaat mlreldivhp avkvlvmate qqkidmgdgt nlvmilagel lnvseklism 121 glsaveiiqg ynmarkftlk eldemvvgei tdkndknell kmikpvissk kygsedilse 181 lvseavshvl pvaqqageip yfnvdsirvv kimggslsns tvikgmvfnr epeghvksls 241 edkkhkvavf tcpldiante tkgtvllhna qemldfskge ekqidammke iadmgveciv 301 agagvgelal hylnrygilv lkvpskfelr rlcrvcgatp lprlgaptpe elglvetvkt 361 meiggdrvtv fkqeqgeisr tstiilrgat qnnlddiera iddgvaavkg lmkpsggkll 421 pgagateiel isritkyger tpgllqlaik qfavafevvp rtlaetagld vnevlpnlya 481 ahnvtepgav ktdhlykgvd idgesdegvk direeniydm latkkfainv ateaattvls 541 idqiimakka ggprapqgpr pgnwdqed // LOCUS NP_001335787 104 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJL007C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335787 VERSION NP_001335787.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348847.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 104) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80307. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..104 /product="uncharacterized protein" /calculated_mol_wt="11725" CDS 1..104 /locus_tag="YJL007C" /coded_by="NM_001348847.1:1..315" /note="hypothetical protein; conserved among S. cerevisiae strains" /db_xref="GeneID:853449" /db_xref="SGD:S000003544" ORIGIN 1 mcsrggsnsr psdyetdalp tellkhtkdv geekqtlhqi fadsmvikgy stgytghtrs 61 spgdlvihkr elifshnivi ivspiymisf iillhyqswh fsiy // LOCUS NP_012528 323 aa linear PLN 30-JUN-2025 DEFINITION Ctk2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012528 VERSION NP_012528.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181440.1 REFERENCE 1 (residues 1 to 323) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 323) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 323) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 323) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08785. Method: conceptual translation. FEATURES Location/Qualifiers source 1..323 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..323 /product="Ctk2p" /calculated_mol_wt="37774" Region 1..299 /region_name="CCL1" /note="Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]; COG5333" /db_xref="CDD:227640" CDS 1..323 /gene="CTK2" /locus_tag="YJL006C" /coded_by="NM_001181440.1:1..972" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15520468]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15520468]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:11118453]" /experiment="EXISTENCE:direct assay:GO:0032786 positive regulation of DNA-templated transcription, elongation [PMID:9110987]" /experiment="EXISTENCE:direct assay:GO:0070692 CTDK-1 complex [PMID:7565723]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15520468]" /experiment="EXISTENCE:physical interaction:GO:0045903 positive regulation of translational fidelity [PMID:17545469]" /note="Beta subunit of C-terminal domain kinase I (CTDK-I); which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:853450" /db_xref="SGD:S000003543" ORIGIN 1 mpstfesqlf fsrpflskrq iqraqkntis dyrnynqkkl avfkflsdlc vqlkfprktl 61 etavyfyqry hlfnrfetev cytvatsclt lgckevetik ktndictlsl rlrnvvkint 121 dilenfkkrv fqielriles csfdyrvnny vhideyviki grelsfdykl cnlawviayd 181 alkletilvi pqhsialail kiayelldnk nwsskryslf etdeksvnea yfdivnfyin 241 sfdmcdlqrh lpadllpigv erfmelkkna gpesglpqip dhllnadpyi titrdnnvqe 301 rryvlsleli ngessinsst rha // LOCUS NP_012529 2026 aa linear PLN 30-JUN-2025 DEFINITION adenylate cyclase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012529 VERSION NP_012529.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181439.3 REFERENCE 1 (residues 1 to 2026) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2026) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2026) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 2026) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2026) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2026) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2026) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08786. On Jul 30, 2012 this sequence version replaced NP_012529.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2026 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..2026 /product="adenylate cyclase" /EC_number="4.6.1.1" /calculated_mol_wt="227704" Region 188..>366 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" Region 368..418 /region_name="Ad_cyc_g-alpha" /note="Adenylate cyclase G-alpha binding domain; pfam08509" /db_xref="CDD:430040" Region 678..776 /region_name="RA_PHLPP_like" /note="Ras-associating (RA) domain found in PH domain leucine-rich repeat-containing protein phosphatases, fungal adenylate cyclase, and similar proteins; cd01775" /db_xref="CDD:340473" Region 796..817 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 818..1252 /region_name="LRR" /note="Leucine-rich repeat (LRR) protein [Transcription]; COG4886" /db_xref="CDD:443914" Region 818..839 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 840..864 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 865..887 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 888..910 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 911..933 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 934..956 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 957..978 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 979..1018 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 1019..1041 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 1042..1065 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 1066..1088 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 1089..1111 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 1167..1187 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 1191..1211 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 1236..1258 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 1259..1287 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Site order(1367,1368,1393..1395,1575,1615) /site_type="active" /db_xref="CDD:238083" Region 1374..1617 /region_name="PP2C" /note="Protein phosphatase 2C; pfam00481" /db_xref="CDD:395385" Region 1613..1825 /region_name="CYCc" /note="Adenylyl- / guanylyl cyclase, catalytic domain; smart00044" /db_xref="CDD:214485" Site order(1671,1673..1678,1712,1714..1716,1719,1794,1798..1799, 1802..1803,1835) /site_type="active" /note="nucleotidyl binding site [active]" /db_xref="CDD:143636" Site order(1673,1716) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:143636" Site order(1678,1689,1692..1693,1696,1700,1712..1713,1782,1785, 1794..1796,1799,1835) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:143636" CDS 1..2026 /gene="CYR1" /locus_tag="YJL005W" /gene_synonym="CDC35; FIL1; HSR1; SRA4; TSM0185" /coded_by="NM_001181439.3:1..6081" /experiment="EXISTENCE:direct assay:GO:0004016 adenylate cyclase activity [PMID:2934138]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:22575457|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:22575457]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:2196438]" /experiment="EXISTENCE:genetic interaction:GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway [PMID:2934138]" /experiment="EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:2934138]" /experiment="EXISTENCE:mutant phenotype:GO:0004016 adenylate cyclase activity [PMID:6360999]" /note="Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; scaffold protein for Ras2-Ira interaction; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation" /db_xref="GeneID:853452" /db_xref="SGD:S000003542" ORIGIN 1 msskpdtgse isgpqrqeeq eqqieqsspt eandrsihde vpkvkkrheq nsghksrrns 61 aysyysprsl smtksresit pngmddvsis nvehprptep kikrgpyllk ktlsslsmts 121 ansthddnkd hgyalnsskt hnytsthnhh dghhdhhhvq ffpnrkpsla etlfkrfsgs 181 nshdgnksgk eskvanlsls tvnpapanrk pskdstlsnh ladnvpstlr rkvsslvrgs 241 svhdinngia dkqirpkava qsentlhssd vpnskrshrk sfllgstsss ssrrgsnvss 301 mtnsdsasma tsgshvlqhn vsnvspttks kdsvnsesad htnnksekvt peynenipen 361 snsdnkreat tptietpisc kpslfrldtn ledvtditkt vpptavnstl nsthgtetas 421 pktvimpegp rksvsmadls vaaaapngef tstsndrsqw vapqswdvet krkktkpkgr 481 sksrrssida deldpmspgp pskkdsrhhh drkdnesmvt agdsnssfvd ickenvpnds 541 ktaldtksvn rlksnlamsp psiryapsnl dgdydtssts sslpsssiss edtsscsdss 601 sytnaymean reqdnktpil nktksytkkf tsssvnmnsp dgaqssglll qdekddevec 661 qlehyykdfs dldpkrhyai rifntddtft tlsctpattv eeiipalkrk fnitaqgnfq 721 islkvgklsk ilrptskpil ierkllllng yrksdplhim giedlsfvfk flfhpvtpsh 781 ftpeqeqrim rsefvhvdlr nmdlttppii fyqhtseies ldvsnnanif lplefiessi 841 kllslrmvni raskfpsnit kayklvslel qrnfirkvpn simklsnlti lnlqcneles 901 lpagfvelkn lqlldlssnk fmhypeviny ctnllqidls ynkiqslpqs tkylvklakm 961 nlshnklnfi gdlsemtdlr tlnlrynris siktnasnlq nlfltdnris nfedtlpklr 1021 aleiqenpit sisfkdfypk nmtsltlnka qlssipgell tklsflekle lnqnnltrlp 1081 qeiskltklv flsvarnkle yippelsqlk slrtldlhsn nirdfvdgme nleltslnis 1141 snafgnssle nsfyhnmsyg sklskslmff iaadnqfdda mwplfncfvn lkvlnlsynn 1201 fsdvshmkle sitelylsgn klttlsgdtv lkwsslktlm lnsnqmlslp aelsnlsqls 1261 vfdvganqlk ynisnyhydw nwrnnkelky lnfsgnrrfe iksfishdid adlsdltvlp 1321 qlkvlglmdv tlnttkvpde nvnfrlrtta siingmrygv adtlgqrdyv ssrdvtferf 1381 rgnddecllc lhdsknqnad yghnisrivr diydkilirq lerygdetdd niktalrfsf 1441 lqlnkeingm lnsvdngadv anlsyadlls gacstviyir gkklfaanlg dcmailsknn 1501 gdyqtltkqh lptkreeyer irisggyvnn gkldgvvdvs ravgffdllp hihaspdisv 1561 vtltkademl ivathklwey mdvdtvcdia renstdplra aaelkdhama ygctenitil 1621 clalyeniqq qnrftlnkns lmtrrstfed ttlrrlqpei spptgnlamv ftdiksstfl 1681 welfpnamrt aikthndimr rqlriyggye vktegdafmv afptptsglt wclsvqlkll 1741 daqwpeeits vqdgcqvtdr ngniiyqgls vrmgihwgcp vpeldlvtqr mdylgpmvnk 1801 aarvqgvadg gqiamssdfy sefnkimkyh ervvkgkesl kevygeeiig evlereiaml 1861 esigwaffdf gehklkglet kelvtiaypk ilasrhefas edeqskline tmlfrlrvis 1921 nrlesimsal sggfieldsr tegsyikfnp kvengimqsi sekdallffd hvitriessv 1981 allhlrqqrc sgleicrndk tsarsnifnv vdellqmvkn akdlst // LOCUS NP_012530 203 aa linear PLN 30-JUN-2025 DEFINITION Sys1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012530 VERSION NP_012530.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181438.1 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 203) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08787. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..203 /product="Sys1p" /calculated_mol_wt="23585" Region 20..163 /region_name="SYS1" /note="Integral membrane protein S linking to the trans Golgi network; pfam09801" /db_xref="CDD:370705" CDS 1..203 /gene="SYS1" /locus_tag="YJL004C" /coded_by="NM_001181438.1:1..612" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:11726510]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:15077113]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:8923208]" /experiment="EXISTENCE:mutant phenotype:GO:0034067 protein localization to Golgi apparatus [PMID:15077113|PMID:15077114]" /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:16926193]" /note="Integral membrane protein of the Golgi; required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation" /db_xref="GeneID:853453" /db_xref="SGD:S000003541" ORIGIN 1 mvsirrylrv pnelkpsqif kqdslspski glqivllqif yyttaivlfy cwaklagydl 61 nikewlfswe nidftnaygl sisllwllds licvffltvi vgrsklawdf aitihainfi 121 vvflytrkfp sfswfflqil ssliliflgt wttrwrelrd tffeglvdpn egevglvtps 181 qqhsnhsele qspiqlkdle sqi // LOCUS NP_012531 118 aa linear PLN 30-JUN-2025 DEFINITION Cox16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012531 VERSION NP_012531.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181437.1 REFERENCE 1 (residues 1 to 118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 118) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08788. Method: conceptual translation. FEATURES Location/Qualifiers source 1..118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..118 /product="Cox16p" /calculated_mol_wt="13946" Region 35..111 /region_name="COX16" /note="Cytochrome c oxidase assembly protein COX16; pfam14138" /db_xref="CDD:464091" CDS 1..118 /gene="COX16" /locus_tag="YJL003W" /coded_by="NM_001181437.1:1..357" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12446688]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:12446688]" /note="Mitochondrial inner membrane protein; required for assembly of cytochrome c oxidase" /db_xref="GeneID:853454" /db_xref="SGD:S000003540" ORIGIN 1 msfsgkkfrs rrqqlvyeas lagrykkals khpflffglp fcativlgsf wlssftaiky 61 eqgdrkvqei needilkirk nqrefdikee yyrlqglsee dwepvrvarl kdesenvw // LOCUS NP_012532 476 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012532 VERSION NP_012532.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181436.3 REFERENCE 1 (residues 1 to 476) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 476) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 476) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 476) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08789. On Jul 30, 2012 this sequence version replaced NP_012532.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..476 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..476 /product="dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1" /calculated_mol_wt="53941" Region 32..468 /region_name="Ribophorin_I" /note="Ribophorin I; pfam04597" /db_xref="CDD:428028" CDS 1..476 /gene="OST1" /locus_tag="YJL002C" /gene_synonym="NLT1" /coded_by="NM_001181436.3:1..1431" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:29301962]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:9015380]" /experiment="EXISTENCE:direct assay:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:29301962]" /experiment="EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]" /experiment="EXISTENCE:direct assay:GO:0018279 protein N-linked glycosylation via asparagine [PMID:9988747]" /experiment="EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]" /note="Alpha subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins" /db_xref="GeneID:853455" /db_xref="SGD:S000003539" ORIGIN 1 mrqvwfswiv glflcffnvs saaqyeppat wenvdykrti dvsnayiset ieitiknias 61 epateyftaf esgifskvsf fsayftneat flnsqllans ttapgddges eirygiiqfp 121 naispqeevs lviksfyntv gipypehvgm seeqhllwet nrlplsaydt kkasftligs 181 ssfeeyhppn desllgkang nsfefgpwed iprfssnetl aivyshnapl nqvvnlrrdi 241 wlshwastiq feeyyeltnk aaklskgfsr lelmkqiqtq nmrqthfvtv ldmllpegat 301 dhyftdlvgl vstshaerdh ffirprfpif ggwnynftvg wtnklsdflh vssgsdekfv 361 asipilngpp dtvydnvels vflpegaeif didspvpftn vsietqksyf dlnkghvklt 421 fsyrnlisqv angqvlikyd ypkssffkkp lsiacyifta lmgvfvlktl nmnvtn // LOCUS NP_012533 215 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit beta 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012533 VERSION NP_012533.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181435.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 215) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08790. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..215 /product="proteasome core particle subunit beta 1" /EC_number="3.4.25.1" /calculated_mol_wt="23417" Region 20..204 /region_name="proteasome_beta_type_6" /note="proteasome beta type-6 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03762" /db_xref="CDD:239731" Site order(20,36,38,52,148,185,188..189) /site_type="active" /db_xref="CDD:239731" Site order(38,41,43..48,68,70,85,96,99..100,102..103,106,109, 133,135,137..140,143,151..152,154..155,158..160,176, 183..186,189..190) /site_type="other" /note="beta subunit interaction site [polypeptide binding]" /db_xref="CDD:239731" CDS 1..215 /gene="PRE3" /locus_tag="YJL001W" /gene_synonym="CRL21" /coded_by="NM_001181435.1:1..648" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /experiment="EXISTENCE:mutant phenotype:GO:0004175 endopeptidase activity [PMID:9207060|PMID:9312134]" /note="Beta 1 subunit of the 20S proteasome; responsible for cleavage after acidic residues in peptides" /db_xref="GeneID:853456" /db_xref="SGD:S000003538" ORIGIN 1 mngiqvdinr lkkgevslgt simavtfkdg vilgadsrtt tgayianrvt dkltrvhdki 61 wccrsgsaad tqaiadivqy hlelytsqyg tpstetaasv fkelcyenkd nltagiivag 121 yddknkgevy tiplggsvhk lpyaiagsgs tfiygycdkn frenmskeet vdfikhslsq 181 aikwdgssgg virmvvltaa gverlifypd eyeql // LOCUS NP_012534 602 aa linear PLN 30-JUN-2025 DEFINITION Avt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012534 VERSION NP_012534.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181658.1 REFERENCE 1 (residues 1 to 602) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 602) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 602) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 602) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08791. Method: conceptual translation. FEATURES Location/Qualifiers source 1..602 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..602 /product="Avt1p" /calculated_mol_wt="65215" Region 206..601 /region_name="Aa_trans" /note="Transmembrane amino acid transporter protein; pfam01490" /db_xref="CDD:279788" CDS 1..602 /gene="AVT1" /locus_tag="YJR001W" /coded_by="NM_001181658.1:1..1809" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:27246536|PMID:11274162]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0003333 amino acid transmembrane transport [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0006865 amino acid transport [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015824 proline transport [PMID:27246536]" /note="Vacuolar transporter; imports large neutral amino acids into vacuole; targeted to vacuole via AP-3 pathway; member of family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" /db_xref="GeneID:853457" /db_xref="SGD:S000003761" ORIGIN 1 mpeqeplspn grkrsevhyi siplnrgsaf spddsvsqfq sdgfmtrrqs ildhpvgsfk 61 gvnslsrfat slrransfrn ielnadners ffkesndety dpdtlapald grrlsvtlnn 121 agrpritnla nndrvstasm aihdddygsi qnstigdsgs ilrptaslte mmsggagrrf 181 tnndmdsivv krvegvdgkv vtllagqsta pqtifnsinv ligigllalp lglkyagwvi 241 gltmlaifal atfctaells rcldtdptli syadlgyaaf gtkgralisa lftldllgsg 301 vslvilfgds lnalfpqyst tffkivsffi vtppvfipls vlsnisllgi lsttgtvlvi 361 cccglyksss pgslvnpmet smwpidlkhl clsigllsac wgghavfpnl ktdmrhpdkf 421 kdclkttyki tsvtdigtav igflmfgnlv kdeitknvll tegypkfvyg lisalmtiip 481 iaktplnarp ivsvldvlmn vqhideaasa ikrraakglq vfnrifinvv fvliainfpe 541 fdkiiaflga glcfticlil pcwfylrlck ttikpwerva chvticisvv lstlgvgaai 601 is // LOCUS NP_012535 593 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein MPP10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012535 VERSION NP_012535.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181659.3 REFERENCE 1 (residues 1 to 593) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 593) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 593) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 593) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08792. On Jul 30, 2012 this sequence version replaced NP_012535.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..593 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..593 /product="rRNA-processing protein MPP10" /calculated_mol_wt="66822" Region 1..593 /region_name="Mpp10" /note="U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and biogenesis]; COG5384" /db_xref="CDD:227674" CDS 1..593 /gene="MPP10" /locus_tag="YJR002W" /coded_by="NM_001181659.3:1..1782" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034457 Mpp10 complex [PMID:17515605]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9315638]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9315638]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9315638]" /experiment="EXISTENCE:mutant phenotype:GO:0032040 small-subunit processome [PMID:12242301]" /note="Component of the SSU processome and 90S preribosome; required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p" /db_xref="GeneID:853458" /db_xref="SGD:S000003762" ORIGIN 1 mselfgvlks nagriilkdp satskdvkay idsvintckn gsitkkaeld eitvdgldan 61 qvwwqvklvl dsidgdliqg iqelkdvvtp shnlsdgstl nsssgeesel eeaesvfkek 121 qmlsadvsei eeqsndslse ndeepsmdde ktsaeaaree faeekrissg qderhsspdp 181 ygindkffdl ekfnrdtlaa edsneasegs ededidyfqd mpsddeeeea iyyedffdkp 241 tkepvkkhsd vkdpkedeel deeehdsamd kvkldlfade edepnaegvg easdknlssf 301 ekqqieirkq ieqleneava ekkwslkgev kakdrpedal lteelefdrt akpvpvitse 361 vtesledmir rriqdsnfdd lqrrtlldit rksqrpqfel sdvkssksla eiyeddytra 421 edesalseel qkahseisel yanlvykldv lssvhfvpkp astsleirve tptismedaq 481 plymsnassl apqeiynvgk aekdgeirlk ngvamskeel tredknrlrr alkrkrskan 541 lpnvnkrskr ndvvdtlska knitvinqkg ekkdvsgktk ksrsgpdstn ikl // LOCUS NP_012536 519 aa linear PLN 30-JUN-2025 DEFINITION Mrx12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012536 VERSION NP_012536.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181660.1 REFERENCE 1 (residues 1 to 519) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 519) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 519) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 519) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08793. On May 22, 2006 this sequence version replaced NP_012536.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..519 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..519 /product="Mrx12p" /calculated_mol_wt="59635" CDS 1..519 /gene="MRX12" /locus_tag="YJR003C" /coded_by="NM_001181660.1:1..1560" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961]" /note="Protein that associates with mitochondrial ribosome; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis" /db_xref="GeneID:853459" /db_xref="SGD:S000003763" ORIGIN 1 mlrslhsaat lsnkrfysli shsnrkniik kllrhpsfdp irhhlpedit tidpyslsqn 61 vieslnklev pkkdaamvhn mmienlsdld ygvatihsnn lrdldlkpsl paikqiirnn 121 pgrvqsswel ftqykasmen vpdelmevvl ekiikfdkae kvdgkkslty qdlvrclyli 181 nhfssnynlp selvepiliy ivdngipnvl gsvlkykipl sffdkyvsem tqyqicelyd 241 fysldnivad plvlhkcltv lgenekiqqt eeekeiiskl eeeidivksq chdnwslefp 301 nwsvrktats feelfleiqk rnidkkdfel ahkllrliga fkgkvslffk lydeyllkfk 361 nneddlmfea fltlccqgyk ssnekmlqya eafikedfds kleskiqsvl ivanakanid 421 lslkiynsni stakrekdky tdlaesdvlt eslilaflsr ddadfarvif dgalgeklis 481 gptaakkikn llaqygeale tktskqvmqt kiehymesi // LOCUS NP_012537 650 aa linear PLN 30-JUN-2025 DEFINITION Sag1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012537 VERSION NP_012537.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181661.1 REFERENCE 1 (residues 1 to 650) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 650) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 650) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 650) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08794. Method: conceptual translation. FEATURES Location/Qualifiers source 1..650 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..650 /product="Sag1p" /calculated_mol_wt="70209" Region 50..300 /region_name="Candida_ALS_N" /note="Cell-wall agglutinin N-terminal ligand-sugar binding; smart01056" /db_xref="CDD:198124" Region 329..>497 /region_name="DUF5585" /note="Family of unknown function (DUF5585); pfam17823" /db_xref="CDD:465521" CDS 1..650 /gene="SAG1" /locus_tag="YJR004C" /gene_synonym="AG(ALPHA)1" /coded_by="NM_001181661.1:1..1953" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000752 agglutination involved in conjugation with cellular fusion [PMID:2677666|PMID:2673555]" /experiment="EXISTENCE:mutant phenotype:GO:0050839 cell adhesion molecule binding [PMID:2673555|PMID:2677666|PMID:11369849]" /note="Alpha-agglutinin of alpha-cells; binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor" /db_xref="GeneID:853460" /db_xref="SGD:S000003764" ORIGIN 1 mftflkiilw lfslalasai ninditfsnl eitpltankq pdqgwtatfd fsiadassir 61 egdeftlsmp hvyrikllns sqtatislad gteafkcyvs qqaaylyent tftctaqndl 121 ssyntidgsi tfslnfsdgg ssyeyelena kffksgpmlv klgnqmsdvv nfdpaaften 181 vfhsgrstgy gsfesyhlgm ycpngyflgg tekidydssn nnvdldcssv qvyssndfnd 241 wwfpqsyndt nadvtcfgsn lwitldekly dgemlwvnal qslpanvnti dhalefqytc 301 ldtianttya tqfsttrefi vyqgrnlgta sakssfistt ttdltsints aystgsistv 361 etgnrttsev ishvvttstk lsptattslt iaqtsiystd snitvgtdih ttsevisdve 421 tisretastv vaaptsttgw tgamntyisq ftsssfatin stpiisssav fetsdasivn 481 vhtenitnta avpseeptfv natrnslnsf csskqpssps sytssplvss lsvsktllst 541 sftpsvptsn tyiktkntgy fehtalttss vglnsfseta vssqgtkidt flvssliayp 601 ssasgsqlsg iqqnftstsl mistyegkas iffsaelgsi iflllsyllf // LOCUS NP_012538 700 aa linear PLN 30-JUN-2025 DEFINITION Apl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012538 VERSION NP_012538.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181662.3 REFERENCE 1 (residues 1 to 700) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 700) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 700) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 700) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08795. On Jul 30, 2012 this sequence version replaced NP_012538.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..700 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..700 /product="Apl1p" /calculated_mol_wt="80323" Region 1..700 /region_name="COG5096" /note="Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]" /db_xref="CDD:227427" CDS 1..700 /gene="APL1" /locus_tag="YJR005W" /gene_synonym="YAP80" /coded_by="NM_001181662.3:1..2103" /experiment="EXISTENCE:curator inference:GO:0016192 vesicle-mediated transport [PMID:22190733]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030122 AP-2 adaptor complex [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0030139 endocytic vesicle [PMID:22190733]" /note="Beta-adaptin; large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex" /db_xref="GeneID:853461" /db_xref="SGD:S000003765" ORIGIN 1 msdqkvfary kaneivtdlq hfgvkkfksn itrrknalrk iianlvlgny gemsvlfsel 61 lkfwqieddl evkricheyi rvigalkpqq arealpfimd dfksrdeklq imalrtlvlv 121 pvkelsdqaf dciislvnhk sppeqvtrta iyalldldei dhervlglss ilhdivkaqs 181 sspevivaal htlysihekn anmepfripl elafdmlell pelnewnkat vlevlttsvv 241 pqhyldthem ielalpylqq vntyvvlnsl kfimyllnyv dviketlaek lsnsvialld 301 kppelqflvl rnvillllsr essllrldis yffieyndpi yikdtklecl yllanketlp 361 rileeleqya tdidiqmsrk svraignlav kldedsvhdc vavlldllef gvdyvvqeii 421 svfrnilrky pnnfkanvte lvkhtevvqe pesknamiwi itqysdvipn ylelfrvfss 481 nmfsetlevq fsilnsaikf firsptkete elcmdllkgc idhennpdlr dktlmywrll 541 sltktsrisn aitfeslksv ldgelpliem ntkldptvle elelnigtiv siylkpvshi 601 frlnktkllp qspilnpnkd llpvvgnsfp ptganrdrqn sesqsstksr ktammddydk 661 paekinqlkg krksssnnps klsrkpstll rklsmkrpfs // LOCUS NP_878106 93 aa linear PLN 30-JUN-2025 DEFINITION Lso1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878106 VERSION NP_878106.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184533.1 REFERENCE 1 (residues 1 to 93) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 93) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 93) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 93) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08796. Method: conceptual translation. FEATURES Location/Qualifiers source 1..93 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..93 /product="Lso1p" /calculated_mol_wt="10738" CDS 1..93 /gene="LSO1" /locus_tag="YJR005C-A" /coded_by="NM_001184533.1:1..282" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26450372]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26450372]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:26450372]" /note="Protein with a potential role in response to iron deprivation; transcription increases during iron deprivation and during treatment with 2-(6-benzyl-2-pyridyl)quinazoline (BPQ) and copper; regulated by Aft1p and, to a lesser extent, by Aft2p; originally identified as a syntenic homolog of an Ashbya gossypii gene; localizes to nucleus and cytoplasm, and nuclear localization is enhanced under iron-replete conditions" /db_xref="GeneID:1466469" /db_xref="SGD:S000028523" ORIGIN 1 mhntgkryse takkvaagra rkrrqayekd qlekqqleaq eaqrweegar tpnqkklime 61 qkkteklrak kerdqllaae eealgkggrg kry // LOCUS NP_012539 487 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed DNA polymerase delta subunit POL31 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012539 VERSION NP_012539.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181663.1 REFERENCE 1 (residues 1 to 487) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 487) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 487) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 487) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08797. Method: conceptual translation. FEATURES Location/Qualifiers source 1..487 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..487 /product="DNA-directed DNA polymerase delta subunit POL31" /EC_number="2.7.7.7" /calculated_mol_wt="55165" Region 52..190 /region_name="DNA_pol_D_N" /note="DNA polymerase delta subunit OB-fold domain; pfam18018" /db_xref="CDD:436215" Region 213..485 /region_name="MPP_PolD2_C" /note="PolD2 (DNA polymerase delta, subunit 2), C-terminal domain; cd07387" /db_xref="CDD:277333" Site order(219,221,262,302..303,356,440) /site_type="active" /note="putative active site [active]" /db_xref="CDD:277333" Site order(219,221,262,302,356,440) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:277333" Site order(230..231,234,238,240..245,281,285,288..289,292..293, 481..485) /site_type="other" /note="PolD3 binding site [polypeptide binding]" /db_xref="CDD:277333" CDS 1..487 /gene="POL31" /locus_tag="YJR006W" /gene_synonym="HUS2; HYS2; SDP5" /coded_by="NM_001181663.1:1..1464" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:18635534]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006278 RNA-templated DNA biosynthetic process [PMID:17429354]" /experiment="EXISTENCE:direct assay:GO:0016035 zeta DNA polymerase complex [PMID:22711820|PMID:23066099]" /experiment="EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:16837458]" /note="Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair; forms a complex with Rev3p, Rev7p and Pol32p; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:853462" /db_xref="SGD:S000003766" ORIGIN 1 mdalltkfne drslqdenls qprtrvrivd dnlynksnpf qlcykkrdyg sqyyhiyqyr 61 lktfrervlk ecdkrwdagf tlngqlvlkk dkvldiqgnq pcwcvgsiyc emkykpnvld 121 evindtygap dltksytdke ggsdeimled esgrvllvgd firstpfitg vvvgilgmea 181 eagtfqvldi cyptplpqnp fpapiatcpt rgkialvsgl nlnntspdrl lrleilrefl 241 mgrinnkidd isligrllic gnsvdfdiks vnkdelmisl tefskflhni lpsisvdimp 301 gtndpsdksl pqqpfhkslf dkslesyfng snkeilnlvt npyefsyngv dvlavsgkni 361 ndickyvips ndngesenkv eegesndfkd diehrldlme ctmkwqniap tapdtlwcyp 421 ytdkdpfvld kwphvyivan qpyfgtrvve iggknikiis vpefsstgmi illdletlea 481 etvkidi // LOCUS NP_012540 304 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF2 subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_012540 VERSION NP_012540.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181664.3 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 304) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08798. On Jul 30, 2012 this sequence version replaced NP_012540.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..304 /product="translation initiation factor eIF2 subunit alpha" /calculated_mol_wt="34587" Region 5..290 /region_name="PTZ00248" /note="eukaryotic translation initiation factor 2 subunit 1; Provisional" /db_xref="CDD:240329" CDS 1..304 /gene="SUI2" /locus_tag="YJR007W" /coded_by="NM_001181664.3:1..915" /experiment="EXISTENCE:direct assay:GO:0001731 formation of translation preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:16565414]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:16246727|PMID:14698289]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:8947054]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:11018020|PMID:15838098]" /experiment="EXISTENCE:direct assay:GO:1990856 methionyl-initiator methionine tRNA binding [PMID:16565414]" /experiment="EXISTENCE:mutant phenotype:GO:0005850 eukaryotic translation initiation factor 2 complex [PMID:2649894]" /note="Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853463" /db_xref="SGD:S000003767" ORIGIN 1 mstshcrfye nkypeiddiv mvnvqqiaem gayvklleyd niegmillse lsrrrirsiq 61 klirvgkndv avvlrvdkek gyidlskrrv ssediikcee kyqksktvhs ilrycaekfq 121 ipleelykti awplsrkfgh ayeafklsii detvwegiep pskdvldelk nyiskrltpq 181 avkiradvev scfsyegida ikdalksaed msteqmqvkv klvaaplyvl ttqaldkqkg 241 ieqlesaiek itevitkygg vcnitmppka vtatedaelq alleskeldn rsdseddede 301 sdde // LOCUS NP_012541 338 aa linear PLN 30-JUN-2025 DEFINITION Mho1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012541 VERSION NP_012541.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181665.1 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 338) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08799. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..338 /product="Mho1p" /calculated_mol_wt="38351" Region 5..334 /region_name="Memo" /note="Memo-like protein; pfam01875" /db_xref="CDD:280116" Site order(12,47,80,138,199,202,284) /site_type="active" /note="putative ligand binding pocket/active site [active]" /db_xref="CDD:153373" Site order(47,80) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:153373" CDS 1..338 /gene="MHO1" /locus_tag="YJR008W" /coded_by="NM_001181665.1:1..1017" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22412880]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22412880|PMID:14562095]" /note="hypothetical protein; inhibits haploid invasive growth when overexpressed; synthetically lethal with phospholipase C (PLC1); expression induced by mild heat-stress on a non-fermentable carbon source, upon entry into stationary phase and upon nitrogen deprivation; repressed by inosine and choline in an Opi1p-dependent manner; highly conserved from bacteria to human; Memo, the human homolog, is an ErbB2 interacting protein with an essential function in cell motility" /db_xref="GeneID:853464" /db_xref="SGD:S000003768" ORIGIN 1 msirpathag swysnraqel sqqlhtylik stlkgpihna riiicphagy rycgptmays 61 yasldlnrnv krifilgpsh hiyfknqilv safseletpl gnlkvdtdlc ktliqkeype 121 ngkklfkpmd hdtdmaehsl emqlpmlvet lkwreisldt vkvfpmmvsh nsvdvdrcig 181 nilseyikdp nnlfivssdf chwgrrfqyt gyvgskeeln daiqeeteve mltarsklsh 241 hqvpiwqsie imdryamktl sdtpngeryd awkqyleitg nticgekpis vilsalskir 301 dagpsgikfq wpnysqsshv tsiddssvsy asgyvtig // LOCUS NP_012542 332 aa linear PLN 30-JUN-2025 DEFINITION glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012542 VERSION NP_012542.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181666.1 REFERENCE 1 (residues 1 to 332) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 332) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 332) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 332) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08800. Method: conceptual translation. FEATURES Location/Qualifiers source 1..332 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..332 /product="glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2" /EC_number="1.2.1.12" /calculated_mol_wt="35716" Region 2..332 /region_name="GapA" /note="Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; COG0057" /db_xref="CDD:439827" CDS 1..332 /gene="TDH2" /locus_tag="YJR009C" /gene_synonym="GLD2" /coded_by="NM_001181666.1:1..999" /experiment="EXISTENCE:direct assay:GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity [PMID:3905788]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11158358|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11158358]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:27184763]" /experiment="EXISTENCE:expression pattern:GO:0006094 gluconeogenesis [PMID:3905788]" /experiment="EXISTENCE:expression pattern:GO:0006096 glycolytic process [PMID:3905788]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17726063]" /experiment="EXISTENCE:mutant phenotype:GO:0072593 reactive oxygen species metabolic process [PMID:17726063]" /note="Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2; involved in glycolysis and gluconeogenesis; tetramer that catalyzes reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in cytoplasm and cell wall; protein abundance increases in response to DNA replication stress; GAPDH-derived antimicrobial peptides are active against a wide variety of wine-related yeasts and bateria; TDH2 has a paralog, TDH3, that arose from the whole genome duplication" /db_xref="GeneID:853465" /db_xref="SGD:S000003769" ORIGIN 1 mvrvaingfg rigrlvmria lqrknvevva lndpfisndy saymfkydst hgryagevsh 61 ddkhiivdgh kiatfqerdp anlpwaslni diaidstgvf keldtaqkhi dagakkvvit 121 apsstapmfv mgvneekyts dlkivsnasc ttnclaplak vindafgiee glmttvhsmt 181 atqktvdgps hkdwrggrta sgniipsstg aakavgkvlp elqgkltgma frvptvdvsv 241 vdltvklnke ttydeikkvv kaaaegklkg vlgytedavv ssdflgdsns sifdaaagiq 301 lspkfvklvs wydneygyst rvvdlvehva ka // LOCUS NP_012543 511 aa linear PLN 30-JUN-2025 DEFINITION sulfate adenylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012543 VERSION NP_012543.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181668.3 REFERENCE 1 (residues 1 to 511) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 511) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 511) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 511) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08801. On Jul 30, 2012 this sequence version replaced NP_012543.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..511 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..511 /product="sulfate adenylyltransferase" /EC_number="2.7.7.4" /calculated_mol_wt="57594" Region 4..386 /region_name="sopT" /note="ATP sulphurylase; TIGR00339" /db_xref="CDD:273023" CDS 1..511 /gene="MET3" /locus_tag="YJR010W" /coded_by="NM_001181668.3:1..1536" /experiment="EXISTENCE:direct assay:GO:0004781 sulfate adenylyltransferase (ATP) activity [PMID:10092498]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:1101032]" /experiment="EXISTENCE:mutant phenotype:GO:0004781 sulfate adenylyltransferase (ATP) activity [PMID:197388]" /experiment="EXISTENCE:mutant phenotype:GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [PMID:197388]" /note="ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant" /db_xref="GeneID:853466" /db_xref="SGD:S000003771" ORIGIN 1 mpaphggilq dliardalkk nellseaqss dilvwnltpr qlcdieliln ggfspltgfl 61 nendyssvvt dsrladgtlw tipitldvde afanqikpdt rialfqddei piailtvqdv 121 ykpnktieae kvfrgdpehp aisylfnvag dyyvggslea iqlpqhydyp glrktpaqlr 181 lefqsrqwdr vvafqtrnpm hrahreltvr aareanakvl ihpvvgltkp gdidhhtrvr 241 vyqeiikryp ngiaflsllp lamrmsgdre avwhaiirkn ygashfivgr dhagpgknsk 301 gvdfygpyda qelvesykhe ldievvpfrm vtylpdedry apidqidttk trtlnisgte 361 lrrrlrvgge ipewfsypev vkilresnpp rpkqgfsivl gnsltvsreq lsiallstfl 421 qfgggryyki fehnnktell sliqdfigsg sgliipnqwe ddkdsvvgkq nvylldtsss 481 adiqlesade pishivqkvv lfledngffv f // LOCUS NP_012544 94 aa linear PLN 30-JUN-2025 DEFINITION signal peptidase complex subunit SPC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012544 VERSION NP_012544.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181667.1 REFERENCE 1 (residues 1 to 94) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 94) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 94) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 94) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08802. Method: conceptual translation. FEATURES Location/Qualifiers source 1..94 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..94 /product="signal peptidase complex subunit SPC1" /calculated_mol_wt="10688" Region 16..86 /region_name="SPC12" /note="Microsomal signal peptidase 12 kDa subunit (SPC12); pfam06645" /db_xref="CDD:461973" CDS 1..94 /gene="SPC1" /locus_tag="YJR010C-A" /coded_by="NM_001181667.1:1..285" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005787 signal peptidase complex [PMID:1846444|PMID:8910564]" /experiment="EXISTENCE:genetic interaction:GO:0006465 signal peptide processing [PMID:8663399]" /experiment="EXISTENCE:genetic interaction:GO:0045047 protein targeting to ER [PMID:8663399]" /experiment="EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:8663399]" /experiment="EXISTENCE:physical interaction:GO:0045047 protein targeting to ER [PMID:8663399]" /note="Subunit of the signal peptidase complex (SPC); SPC cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER); regulates cellular levels of membrane proteins; homolog of the SPC12 subunit of mammalian signal peptidase complex; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853467" /db_xref="SGD:S000003770" ORIGIN 1 mseilqdvqr klvfpidfps qrktekfqql slmigalvac ilgfaqqslk vlltaygisc 61 vitlicvlpa ypwynkqklr waqpkieinv dqyd // LOCUS NP_012545 261 aa linear PLN 30-JUN-2025 DEFINITION Cal4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012545 VERSION NP_012545.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181669.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 261) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08803. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..261 /product="Cal4p" /calculated_mol_wt="30342" CDS 1..261 /gene="CAL4" /locus_tag="YJR011C" /coded_by="NM_001181669.1:1..786" /note="Accessory component of the Ccr4-NOT complex; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:853468" /db_xref="SGD:S000003772" ORIGIN 1 msetresnes tvsslqtkll lndgisennk knvillnqiv pfilntshym tdlmyvlyyl 61 aqkqedevln hsgtfishkk ellalksdic eliydlrtgf rllldsceld hfetpgkcrh 121 liekvlvtsi ygvnryifqe lnrlnvdfkd efilqmqncl sgfvnlykfl nkipmskqqs 181 qmndlqmkil vnvlqnellp iwkfqldlln cklfnelskd kgliniyrka tndsvidvsk 241 gepfiryvnw lkdqiigemt v // LOCUS NP_012546 132 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR012C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012546 VERSION NP_012546.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181670.4 REFERENCE 1 (residues 1 to 132) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 132) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 132) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 132) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08804. On May 27, 2021 this sequence version replaced NP_012546.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..132 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..132 /product="uncharacterized protein" /calculated_mol_wt="14435" Region 7..51 /region_name="DUF5572" /note="Family of unknown function (DUF5572); pfam17733" /db_xref="CDD:436001" CDS 1..132 /locus_tag="YJR012C" /coded_by="NM_001181670.4:1..399" /note="hypothetical protein; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; null mutant is viable" /db_xref="GeneID:853469" /db_xref="SGD:S000003773" ORIGIN 1 maaggelsye elldhilnnk pipnivevpn vtldeglast pslrprprpw egqlqhqshq 61 gsldkpnisl didqeslegm tsltrlsecy diqsklqind sdndnddnnn dnnkgdgndd 121 dnntvtanpt ar // LOCUS NP_012547 403 aa linear PLN 30-JUN-2025 DEFINITION glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I [Saccharomyces cerevisiae S288C]. ACCESSION NP_012547 VERSION NP_012547.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181671.1 REFERENCE 1 (residues 1 to 403) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 403) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 403) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 403) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08805. On Feb 23, 2004 this sequence version replaced NP_012547.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..403 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..403 /product="glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I" /calculated_mol_wt="47035" Region 127..386 /region_name="Mannosyl_trans" /note="Mannosyltransferase (PIG-M); pfam05007" /db_xref="CDD:252941" CDS 1..403 /gene="GPI14" /locus_tag="YJR013W" /gene_synonym="PMH1" /coded_by="NM_001181671.1:1..1212" /experiment="EXISTENCE:direct assay:GO:0000030 mannosyltransferase activity [PMID:15635094]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:16134120]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:16134120]" /experiment="EXISTENCE:physical interaction:GO:0006506 GPI anchor biosynthetic process [PMID:15635094]" /experiment="EXISTENCE:physical interaction:GO:1990529 glycosylphosphatidylinositol-mannosyltransferase I complex [PMID:15635094]" /note="Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I; involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M" /db_xref="GeneID:853470" /db_xref="SGD:S000003774" ORIGIN 1 mtgeewgltv lsflvrvgff lfgiyqdanf kvrytdidyf vfhdaakyvy egkspyardt 61 yrytpllswl lvpnhyfgwf hlgkvifvif dlvtgliimk llnqaisrkr alilesiwll 121 npmvitistr gnaesvlccl imftlfflqk srytlagily glsihfkiyp iiycipiaif 181 iyynkrnqgp rtqltsllni glstlttllg cgwamykiyg yefldqayly hlyrtdhrhn 241 fsvwnmllyl dsankenges nlsryafvpq lllvlvtgcl ewwnptfdnl lrvlfvqtfa 301 fvtynkvcts qyfvwylifl pfylsrthig wkkgllmatl wvgtqgiwls qgyylefegk 361 nvfypglfia svlffvtnvw llgqfitdik iptqptvsnk knn // LOCUS NP_012548 198 aa linear PLN 30-JUN-2025 DEFINITION Tma22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012548 VERSION NP_012548.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181672.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 198) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08806. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..198 /product="Tma22p" /calculated_mol_wt="22364" Region 2..181 /region_name="DRP1" /note="density-regulated protein DRP1; TIGR01159" /db_xref="CDD:273472" Site order(106,109..110,112,130,133..135,137..139,141,155,158) /site_type="other" /note="putative rRNA binding site [nucleotide binding]" /db_xref="CDD:211320" CDS 1..198 /gene="TMA22" /locus_tag="YJR014W" /coded_by="NM_001181672.1:1..597" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:38198768]" /experiment="EXISTENCE:mutant phenotype:GO:0032790 ribosome disassembly [PMID:34016977]" /note="Ribosome-associated protein; involved along with heterodimeric partner Tma20p in recycling of 40S ribosomal subunits; involved in nonsense-mediated mRNA decay (NMD); contains a putative RNA binding domain; localizes to the cytoplasm in HTP studies; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853471" /db_xref="SGD:S000003775" ORIGIN 1 mlreviycgi csyppeycef sgklkrckvw lsenhadlya klygtddntq eveavtnkla 61 essigearee klekdllkiq kkqenreqre lakklsskvi ikreartkrk fivaisglev 121 fdidmkklak tfasrfatgc svsknaekke evviqgdvmd evetyihsll eekglkdvkv 181 etidakkkkk paaegaak // LOCUS NP_012549 510 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR015W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012549 VERSION NP_012549.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181673.3 REFERENCE 1 (residues 1 to 510) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 510) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 510) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 510) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08807. On Jul 30, 2012 this sequence version replaced NP_012549.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..510 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..510 /product="uncharacterized protein" /calculated_mol_wt="57986" Region 96..486 /region_name="DUF3533" /note="Protein of unknown function (DUF3533); pfam12051" /db_xref="CDD:432289" CDS 1..510 /locus_tag="YJR015W" /coded_by="NM_001181673.3:1..1533" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /note="hypothetical protein; localizes to endoplasmic reticulum and cytoplasm; null mutant exhibits abnormal lipid metabolic phenotype; predicted to encode a membrane transporter based on phylogenetic analysis; not an essential gene; YJR015W has a paralog, SNG1, that arose from the whole genome duplication" /db_xref="GeneID:853472" /db_xref="SGD:S000003776" ORIGIN 1 mtsslddiep taynnmeade eycrrndihd lssvvgdavs qgvpdmdgqt tdsskdpepn 61 sedkkafpps sgsffspnlq gqrkkvllkf vftncllaii cftmfvlfwg alydtskylh 121 kvkllvviqe ppvvildnns smvvpsisya lptfinkipc dwdiynsptf qakfdvntpq 181 qvndkvvdlv ydekywfain ikpnatetlf eslindtapl fnstlfnqvv yetgrdptnl 241 kstilpvaqt ieeyyhtfyt lnylpplltn itqvyryalt nnaryiaaag kynyeyydhr 301 pftdrillap tqigvvycll ltffqfllyg plhvemakvl rpangliyri amswftfffa 361 slffctttai fqvdftksfg rggfvvywms twlfmlaagg anenavmlvi tlgpqylgfw 421 ilsfvilnia psffplalnn nvyrygymmp vhnvidiyrv iffdvtrrkm grnygilval 481 ialntallpf vgkyasrklk qkalvaakqs // LOCUS NP_012550 585 aa linear PLN 30-JUN-2025 DEFINITION dihydroxy-acid dehydratase ILV3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012550 VERSION NP_012550.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181674.1 REFERENCE 1 (residues 1 to 585) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 585) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 585) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 585) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08808. Method: conceptual translation. FEATURES Location/Qualifiers source 1..585 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..585 /product="dihydroxy-acid dehydratase ILV3" /EC_number="4.2.1.9" /calculated_mol_wt="62730" Region 45..584 /region_name="ilvD" /note="dihydroxy-acid dehydratase; TIGR00110" /db_xref="CDD:272910" CDS 1..585 /gene="ILV3" /locus_tag="YJR016C" /coded_by="NM_001181674.1:1..1758" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0004160 dihydroxy-acid dehydratase activity [PMID:14124940]" /experiment="EXISTENCE:mutant phenotype:GO:0009082 branched-chain amino acid biosynthetic process [PMID:14124940]" /note="Dihydroxyacid dehydratase; putative 2Fe-2S protein; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids" /db_xref="GeneID:853473" /db_xref="SGD:S000003777" ORIGIN 1 mglltkvats rqfsttrcva kklnkysyii tepkgqgasq amlyatgfkk edfkkpqvgv 61 gscwwsgnpc nmhlldlnnr csqsiekagl kamqfntigv sdgismgtkg mryslqsrei 121 iadsfetimm aqhydaniai pscdknmpgv mmamgrhnrp simvyggtil pghptcgssk 181 isknidivsa fqsygeyisk qfteeeredv vehacpgpgs cggmytantm asaaevlglt 241 ipnsssfpav skeklaecdn igeyikktme lgilprdilt keafenaity vvatggstna 301 vlhlvavahs agvklspddf qrisdttpli gdfkpsgkyv madlinvggt qsvikylyen 361 nmlhgntmtv tgdtlaerak kapslpegqe iikplshpik anghlqilyg slapggavgk 421 itgkegtyfk grarvfeeeg afiealerge ikkgektvvv iryegprgap gmpemlkpss 481 almgyglgkd valltdgrfs ggshgfligh ivpeaaeggp iglvrdgdei iidadnnkid 541 llvsdkemaq rkqswvappp rytrgtlsky aklvsnasng cvlda // LOCUS NP_012551 170 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase ESS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012551 VERSION NP_012551.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181675.1 REFERENCE 1 (residues 1 to 170) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 170) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 170) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 170) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08809. On Oct 2, 2003 this sequence version replaced NP_012551.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..170 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..170 /product="peptidylprolyl isomerase ESS1" /EC_number="5.2.1.8" /calculated_mol_wt="19274" Region 10..43 /region_name="WW" /note="Domain with 2 conserved Trp (W) residues; smart00456" /db_xref="CDD:197736" Site order(27,38) /site_type="active" /note="binding pocket [active]" /db_xref="CDD:238122" Region 59..170 /region_name="Rotamase_2" /note="PPIC-type PPIASE domain; cl29122" /db_xref="CDD:452928" CDS 1..170 /gene="ESS1" /locus_tag="YJR017C" /gene_synonym="PIN1; PTF1" /coded_by="NM_001181675.1:1..513" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10899126|PMID:14704159|PMID:10531363]" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:15728580|PMID:9867817]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:14704159]" /experiment="EXISTENCE:genetic interaction:GO:0006369 termination of RNA polymerase II transcription [PMID:19854134]" /experiment="EXISTENCE:genetic interaction:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:15166139]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10899126]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:14704159]" /experiment="EXISTENCE:mutant phenotype:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:15728580]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:22778132|PMID:14704159|PMID:19854134]" /experiment="EXISTENCE:mutant phenotype:GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process [PMID:19597489]" /experiment="EXISTENCE:mutant phenotype:GO:2000749 positive regulation of rDNA heterochromatin formation [PMID:10899127]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:10531363|PMID:10899126]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10899126]" /note="Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated S/T residues N-terminal to proline; regulates phosphorylation of RNAPII large subunit (Rpo21p) C-terminal domain (CTD) at Ser7; associates with phospho-Ser5 form of RNAPII in vivo; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription, trimethylation of histone H3; human ortholog PIN1 can complement yeast null and ts mutants" /db_xref="GeneID:853475" /db_xref="SGD:S000003778" ORIGIN 1 mpsdvasrtg lptpwtvrys kskkreyffn petkhsqwee pegtnkdqlh khlrdhpvrv 61 rclhilikhk dsrrpashrs enitiskqda tdelktlitr ldddsktnsf ealakersdc 121 ssykrggdlg wfgrgemqps fedaafqlkv gevsdivesg sgvhvikrvg // LOCUS NP_012553 349 aa linear PLN 30-JUN-2025 DEFINITION palmitoyl-CoA hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012553 VERSION NP_012553.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181677.3 REFERENCE 1 (residues 1 to 349) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 349) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 349) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 349) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08810. On Jul 30, 2012 this sequence version replaced NP_012553.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..349 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..349 /product="palmitoyl-CoA hydrolase" /EC_number="3.1.2.2" /calculated_mol_wt="40129" Region 18..338 /region_name="tesB" /note="acyl-CoA thioesterase II; TIGR00189" /db_xref="CDD:272951" CDS 1..349 /gene="TES1" /locus_tag="YJR019C" /gene_synonym="PTE1" /coded_by="NM_001181677.3:1..1050" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:10092594]" /experiment="EXISTENCE:direct assay:GO:0008474 palmitoyl-(protein) hydrolase activity [PMID:10092594]" /experiment="EXISTENCE:direct assay:GO:0047617 fatty acyl-CoA hydrolase activity [PMID:10092594]" /experiment="EXISTENCE:direct assay:GO:0052816 long-chain fatty acyl-CoA hydrolase activity [PMID:10092594]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:19830908]" /experiment="EXISTENCE:mutant phenotype:GO:0019395 fatty acid oxidation [PMID:10092594]" /note="Peroxisomal acyl-CoA thioesterase; likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids" /db_xref="GeneID:853477" /db_xref="SGD:S000003780" ORIGIN 1 msaskmamsn lekilelvpl sptsfvtkyl paapvgskgt fggtlvsqsl laslhtvpln 61 ffptslhsyf ikggdprtki tyhvqnlrng rnfihkqvsa yqhdklifts milfavqrsk 121 ehdslqhwet ipglqgkqpd phryeeatsl fqkevldpqk lsryaslsdr fqdatsmsky 181 vdafqygvme yqfpkdmfys arhtdeldyf vkvrppittv ehagdesslh khhpyripks 241 itpendaryn yvafaylsds yllltipyfh nlplychsfs vsldhtiyfh qlphvnnwiy 301 lkisnprshw dkhlvqgkyf dtqsgrimas vsqegyvvyg serdirakf // LOCUS NP_012555 314 aa linear PLN 30-JUN-2025 DEFINITION Rec107p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012555 VERSION NP_012555.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181679.1 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 314) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08811. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..314 /product="Rec107p" /calculated_mol_wt="35552" Region 26..214 /region_name="Mer2" /note="pfam09074" /db_xref="CDD:401133" CDS 1..314 /gene="REC107" /locus_tag="YJR021C" /gene_synonym="MER2" /coded_by="NM_001181679.1:1..945" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16783010]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:8536989]" /note="Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation" /db_xref="GeneID:853478" /db_xref="SGD:S000003782" ORIGIN 1 mvargrtdei stdvseanse hslmitetss pfrsifshsg kvanagalee sdkqilewag 61 klelesmelr ensdklikvl nensktlcks lnkfnqlleq daatngnvkt likdlasqie 121 nqldkvstam lskgdekktk sdssyrqvlv eeisrynski trhvtnkqhe teksmrctqe 181 mlfnvgsqle dvhkvllsls kdmhslqtrq talemafrek adhaydrpdv slngttllhd 241 mdeahdkqrk ksvppprmmv trsmkrrrss sptlstsqnh nsednddash rlkraartii 301 pweelrpdtl esel // LOCUS NP_012556 109 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit LSM8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012556 VERSION NP_012556.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181680.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 109) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08812. On Oct 2, 2003 this sequence version replaced NP_012556.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..109 /product="U4/U6-U5 snRNP complex subunit LSM8" /calculated_mol_wt="12254" Region 2..85 /region_name="LSm8" /note="Like-Sm protein 8; cd01727" /db_xref="CDD:212474" Site order(5,8..9,14,16..18,21,23,28..31,34..35,37,53..65) /site_type="other" /note="putative oligomer interface [polypeptide binding]" /db_xref="CDD:212474" Site order(13..19,21..33,35..39) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212474" Site order(31,33,57) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:212474" Site 53..64 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212474" CDS 1..109 /gene="LSM8" /locus_tag="YJR022W" /coded_by="NM_001181680.1:1..330" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10369684|PMID:15075370]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12730603]" /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:11720284|PMID:10369684]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:18029398]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970]" /note="Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA" /db_xref="GeneID:853479" /db_xref="SGD:S000003783" ORIGIN 1 msatlkdyln krvviikvdg ecliaslngf dkntnlfitn vfnriskefi ckaqllrgse 61 ialvglidae nddslapide kkvpmlkdtk nkienehviw ekvyesktk // LOCUS NP_012558 244 aa linear PLN 30-JUN-2025 DEFINITION methylthioribulose 1-phosphate dehydratase MDE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012558 VERSION NP_012558.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181682.3 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 244) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08813. On Jul 30, 2012 this sequence version replaced NP_012558.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..244 /product="methylthioribulose 1-phosphate dehydratase MDE1" /EC_number="4.2.1.109" /calculated_mol_wt="27296" Region 14..238 /region_name="Aldolase_II" /note="Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); cd00398" /db_xref="CDD:238232" Site order(22,26,34,58,60..61,109,111..112,117..119,138, 140..141,163,191,202,209,213,220,234) /site_type="other" /note="intersubunit interface [polypeptide binding]" /db_xref="CDD:238232" Site order(39,55..56,87..89,107,109,192) /site_type="active" /db_xref="CDD:238232" Site order(107,109,192) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238232" CDS 1..244 /gene="MDE1" /locus_tag="YJR024C" /coded_by="NM_001181682.3:1..735" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:18625006]" /experiment="EXISTENCE:mutant phenotype:GO:0046570 methylthioribulose 1-phosphate dehydratase activity [PMID:18625006]" /note="5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant" /db_xref="GeneID:853481" /db_xref="SGD:S000003785" ORIGIN 1 mssqdvlihs ddpchpanli ctlckqffhn nwctgtgggi sikdpntnyy ylapsgvqke 61 kmipedlfvm daqtleylrs pklykpsact plflacyqkk nagaiihths qnavicsllf 121 gdefrianie qikaipsgkv dpvtkkpmal sffdtlkipi ienmahedel iddlhktfkd 181 ypdtcavivr rhgifvwgpt idkakifnea idylmelaik myqmgippdc gigeekkhlk 241 masp // LOCUS NP_012559 177 aa linear PLN 30-JUN-2025 DEFINITION 3-hydroxyanthranilate 3,4-dioxygenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012559 VERSION NP_012559.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181683.1 REFERENCE 1 (residues 1 to 177) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 177) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 177) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 177) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08814. Method: conceptual translation. FEATURES Location/Qualifiers source 1..177 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..177 /product="3-hydroxyanthranilate 3,4-dioxygenase" /EC_number="1.13.11.6" /calculated_mol_wt="20104" Region 1..155 /region_name="cupin_RmlC-like" /note="RmlC-like cupin superfamily; cl40423" /db_xref="CDD:477354" Site order(30,34,54,56,82,85..89,110,112) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:380378" Site order(49,55,97,111) /site_type="active" /db_xref="CDD:380378" CDS 1..177 /gene="BNA1" /locus_tag="YJR025C" /gene_synonym="HAD1" /coded_by="NM_001181683.1:1..534" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11901108]" /experiment="EXISTENCE:genetic interaction:GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan [PMID:12062417]" /experiment="EXISTENCE:mutant phenotype:GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity [PMID:9539135]" /note="3-hydroxyanthranilic acid dioxygenase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p" /db_xref="GeneID:853482" /db_xref="SGD:S000003786" ORIGIN 1 mfnttpinid kwlkenegll kppvnnyclh kggftvmivg gpnertgyhi nptpewfyqk 61 kgsmllkvvd etdaepkfid iiinegdsyl lpgnvphspv rfadtvgivv eqdrpggend 121 kirwycshcr qvvheselqm ldlgtqvkea ildfendvek rtcfhcktln yarpqsn // LOCUS NP_012561 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012561 VERSION NP_012561.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181684.3 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 440) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08816. On Jul 30, 2012 this sequence version replaced NP_012561.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..440 /product="gag protein" /calculated_mol_wt="48862" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YJR026W" /coded_by="NM_001181684.3:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:853483" /db_xref="SGD:S000003787" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_012560 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012560 VERSION NP_012560.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181685.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1755) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08815. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198522" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YJR027W" /coded_by="join(NM_001181685.2:1..1302, NM_001181685.2:1304..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:853484" /db_xref="SGD:S000003788" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivqy gdfywvskry llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyqsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd eyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydtgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 hyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniflln gkviggkstk asltctstte aeihaisesv pllnnlsyli qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_012563 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012563 VERSION NP_012563.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181686.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 440) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08818. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..440 /product="gag protein" /calculated_mol_wt="48981" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YJR028W" /coded_by="NM_001181686.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:853485" /db_xref="SGD:S000003789" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqtaqshsp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_012562 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012562 VERSION NP_012562.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181687.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1755) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08817. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198487" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YJR029W" /coded_by="join(NM_001181687.2:1..1301, NM_001181687.2:1303..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:853486" /db_xref="SGD:S000003790" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqtaqshsp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsd dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd eyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli qqcgmeevrg wscvfknsqv ticlfvddmv lfsknlnsnk 1441 riieklkmqy dtkiinlges deeiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqq eleleeddyk mkvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsk qvldmtyeli qfiwntrdkq liwhkskpvk ptnklvvisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qeldkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_012564 745 aa linear PLN 30-JUN-2025 DEFINITION Rbh2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012564 VERSION NP_012564.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181688.3 REFERENCE 1 (residues 1 to 745) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 745) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 745) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 745) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 745) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 745) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 745) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08819. On Jul 30, 2012 this sequence version replaced NP_012564.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..745 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..745 /product="Rbh2p" /calculated_mol_wt="84159" CDS 1..745 /gene="RBH2" /locus_tag="YJR030C" /coded_by="NM_001181688.3:1..2238" /experiment="EXISTENCE:mutant phenotype:GO:0019320 hexose catabolic process [PMID:23185390]" /note="hypothetical protein; expression repressed in carbon limited vs carbon replete chemostat cultures; non-essential gene; contains a PH-like domain; RBH2 has a paralog, RBH1, that arose from the whole genome duplication" /db_xref="GeneID:853487" /db_xref="SGD:S000003791" ORIGIN 1 melfnkeeas fetllkrllv vceshsryhg ssldpmvkvg hemrkisgyl rcilrkhaan 61 hddmsltqsi vnsykslfkd aqildlyhnl lfgcmhllld anmsyfrmds qklfavllfk 121 vyyklrdify vtnevrlgsl isafvykfks cydfiscnsl kygsvrdvis gevslinlpp 181 idsnkvinra yyrldvkkla innklveile ldngeiaife vlsekmpytl qtidnlfqsl 241 algnhdlmnv grsllfrpfr sgdldlirld dsgaklkvpi nnsivlrltc kdpiqwqeyw 301 khvirklfds tatkeykrsg skisqqvyvr snnpdytspk rnddmpissv kisdtihngr 361 tlhrsiplpg slsslietsn eypdeeslsi mseratvsed sdldtslkdi eslsceklie 421 ldksiqvpls pkymdtptlk nirtasqtfs lesvspelie svaseiddse siisedgkdk 481 rdkdlfdpdi dfykptlyrr ksssllsifs knkknltidi pknhsrslfs lpgnqqsvtp 541 vsatphddnv detyvsfpls intsggavyf endsvkvslw ngkswvplsk dmlclslils 601 gdnetllivy kdfekekckl vvkleptwky nrstaqdvql ripssdfkas vfgtlhdltl 661 sircaqaakl vnvlqyqlqs sqtsslspst ttgtlstvss sscfsrnvtr sstenselan 721 mkdsseyiss slllssvkvr qlrnm // LOCUS NP_012565 1408 aa linear PLN 30-JUN-2025 DEFINITION Arf family guanine nucleotide exchange factor GEA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012565 VERSION NP_012565.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181689.1 REFERENCE 1 (residues 1 to 1408) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1408) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1408) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1408) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08820. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1408 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1408 /product="Arf family guanine nucleotide exchange factor GEA1" /calculated_mol_wt="159307" Region 328..471 /region_name="Sec7_N" /note="Guanine nucleotide exchange factor in Golgi transport N-terminal; pfam12783" /db_xref="CDD:463703" Region 541..748 /region_name="Sec7" /note="Sec7 domain; pfam01369" /db_xref="CDD:460178" CDS 1..1408 /gene="GEA1" /locus_tag="YJR031C" /coded_by="NM_001181689.1:1..4227" /experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:11294905]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10430582]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11294905]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:14668359]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8945477|PMID:11493664]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11493664]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20444982]" /note="Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA1 has a paralog, GEA2, that arose from the whole genome duplication" /db_xref="GeneID:853488" /db_xref="SGD:S000003792" ORIGIN 1 mhdvpmetvl avnpatmivk ecinlcsamn kqsrdksqts vaallgggsd iflsqsdsfv 61 dsfhnlptss yhdplisglv qlrlkindlk gldslnalel lkpfleivsa ssvsgyttsl 121 aldslqkvft lkiinktfnd iqiavretvv althcrfeas kqisddsvll kvvtllrdii 181 tssfgdylsd tiiydvlqtt lslacntqrs evlrktaevt iagitvklft klklldpptk 241 tekyindesy tdnnlkddii gtttsdndls stdddsavad dnknekpvqq vireqendee 301 taekaenvep nygitvikdy lglllslvmp enrmkhttsa mklslqlina aieisgdkfp 361 lyprlfslis dpifksvlfi iqsstqysll qatlqlftsl vvilgdylpm qieltlrrif 421 eiledttisg dvskqkppai reliieqlsi lwihspaffl qlfvnfdcnl drsdlsidfi 481 keltkfslpa aavntsnnip piclegvlsl ieniyndlqr fdraefvknq keidilkqrd 541 rktefilcve tfnekakkgi qmliekgfid sdsnrdiasf lflnngrlnk ktiglllcdp 601 kktsllkefi dlfdfkglrv deairilltk frlpgesqqi eriveafssk ysadqsndkv 661 eledkkagkn gsesmteddi ihvqpdadsv fvlsysiiml ntdshnpqvk dhmtfddysn 721 nlrgcyngkd fprwylhkiy tsikvkeivm peehhgnerw fedawnnlis stsvmtemqr 781 dftnpiskla qidilqyeka ifsnvrdiil ktlfkiftva ssdqislril daiskctfin 841 yyfsfdqsyn dtvlhlgemt tlaqssakav eldvdsiplv eifvedtgsk isvsnqsirl 901 gqnfkaqlct vlyfqiikei sdpsivstrl wnqivqlilk lfenllmepn lpfftnfhsl 961 lklpelplpd pdisirkakm srsllstfas ylkgdeepse edidfsikaf ecvkashpls 1021 svfennqlvs pkmietllss lviektsens pyfeqellfl leisiilise asygqefgal 1081 iadhminisn ldglskeaia rlasykmflv srfdnprdil sdliehdflv kneifntkyy 1141 esewgkqvin dlfthlndvk yneralknvk fwnflrilis akdrqfavyt flekyiqngd 1201 ifvddgnfmn ilslldemsc agavgtkweq nyensvedgc eapesnpyrs iidlssrsin 1261 itadllstvg rsnsalnkne iiaaiqglah qclnpcdelg mqalqaleni llsrasqlrt 1321 ekvavdnlle tgllpifeld eiqdvkmkri tsilsvlski flgqlvegvt snetflrvln 1381 vfnkyvddpt verqlqelii skreieke // LOCUS NP_012566 393 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase CPR7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012566 VERSION NP_012566.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181690.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 393) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08821. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..393 /product="peptidylprolyl isomerase CPR7" /EC_number="5.2.1.8" /calculated_mol_wt="45003" Region 5..195 /region_name="cyclophilin" /note="cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug...; cl00197" /db_xref="CDD:469651" Site order(64,66,69..70,72,132..133,143,145,153..154,158) /site_type="active" /db_xref="CDD:238194" Region 247..>382 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" Site order(248..249,251,276,296..297,300..301,303..304,331, 334..335,338..339,342) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 274..321 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 330..353 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..393 /gene="CPR7" /locus_tag="YJR032W" /coded_by="NM_001181690.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:10942767]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:10942767]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:10942767]" /experiment="EXISTENCE:physical interaction:GO:0005829 cytosol [PMID:10942767]" /note="Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity; plays a role in determining prion variants" /db_xref="GeneID:853489" /db_xref="SGD:S000003793" ORIGIN 1 miqdplvyld isidkkpigr ivcklfreka pkttenfykl cagdvksplk dqqylsykgn 61 gfhrvvknfm iqagdivfgt qkdsssssvg kggcsiyadk eevktddesf cygnfedenl 121 gefvepftlg manlgspntn nsqffittya aphlngkhsi fgqvvhgksv vrtiencrvd 181 sdgvpesdvr isdcgvwekt mgvplynasn dqiggdvyee ypdddthfgd ddfgkaleaa 241 niikesgtll fkkkdysnaf fkyrkslnyi neympepdvd kerniqfinl kmkiylnlsl 301 vlfnlerydd aimyatylle mdnvpnrdqa kayyrrgnsy lkkkrldeal qdyifckekn 361 pddevieqri eyvnrlieen kektrknisk ffs // LOCUS NP_012567 1357 aa linear PLN 30-JUN-2025 DEFINITION Rav1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012567 VERSION NP_012567.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181691.3 REFERENCE 1 (residues 1 to 1357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1357) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08822. On Jul 30, 2012 this sequence version replaced NP_012567.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1357 /product="Rav1p" /calculated_mol_wt="154803" Region <23..230 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 573..1190 /region_name="Rav1p_C" /note="RAVE protein 1 C terminal; pfam12234" /db_xref="CDD:432413" CDS 1..1357 /gene="RAV1" /locus_tag="YJR033C" /gene_synonym="SOI3" /coded_by="NM_001181691.3:1..4074" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11283612]" /experiment="EXISTENCE:genetic interaction:GO:0007035 vacuolar acidification [PMID:11844802|PMID:11283612]" /experiment="EXISTENCE:genetic interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:11844802]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:11283612|PMID:11844802]" /experiment="EXISTENCE:mutant phenotype:GO:0043254 regulation of protein-containing complex assembly [PMID:11844802|PMID:11283612]" /experiment="EXISTENCE:mutant phenotype:GO:0045022 early endosome to late endosome transport [PMID:15090613]" /experiment="EXISTENCE:physical interaction:GO:0043254 regulation of protein-containing complex assembly [PMID:11283612]" /experiment="EXISTENCE:physical interaction:GO:0043291 RAVE complex [PMID:11844802|PMID:11283612]" /note="Subunit of RAVE complex (Rav1p, Rav2p, Skp1p); the RAVE complex promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate" /db_xref="GeneID:853490" /db_xref="SGD:S000003794" ORIGIN 1 mslnflpgrp natpqtacqa twqnhtifay csgnnliilt nkftrlqtiy tqsdctavdi 61 nsqngfials fhnrvliykp ihqimqnpkw tqccqlfhdd tpvnclrwss dnelaigsdf 121 lsfwkikdnf gvyqpilqwn qkqpkpvynv iisqdsqliv sigkydcnak lwkrvsivge 181 qaifnltmlp hpkpitamrw kkepdqvskn ntashalytl cedkvlriws cfemeknhtv 241 qiwgevplsp tqkfcviidn wiirqtlsvk dseifdisds divilgsmtg emevlalnnl 301 sqdppkpmtk ktishkkvkk atmlndtryl ylpeiqpydn vkgklsflvh dlqgvirhll 361 idilqlinnk tedlsaaleh kftghnksvq klvrssdgea llttsrfsen gvwypqklnh 421 gvslrlqnti qtespikfav vhelgkqvic llengalqaw ecptnrkeds eqkqsylrve 481 trlkeekkih pivmlntpep khsherhfta lifsdgsika fevsltrgif evksdsldid 541 gddiykisii dpvhqtfvsn rplislitkk gltrtykaiv nyndrhvqwi kaceintgim 601 nctcirgsst gklcivnstg kvmslwdlnr gvleyeetfh npiedidwts teygqsivsi 661 gftgyallyt qlrydytnnt psylpiekid itahtahnig dsvwmkngtf vvasgnqfyi 721 kdksldltdp ftyqsigsrk ilsndilhls svlngplpvy hpqfliqaiy anklqlvkel 781 llrlflalrk ldfesqdvsn ldsnlgmdpl kyfiakdrdy pvesfpdpyp cfnktvslal 841 teqltkttlp yltrhqqitl itvieavdev tknenivdyn gvrfllgvkl flshkniqks 901 ilmrdvswal hsdnkeills sidrhitswn rareyriayw ikeqdlvkkf ediakyefsk 961 ddkrdpsrca ifylalkkkq illslwkmai ghpeqqkmvr fisndftvpr wrtaalknaf 1021 vllskhrymd aavfflltds lkdcvnvlck qvhdmdlaig vcrvyegdng pvlgelltaq 1081 mlpetikend rwkasfiywk lrkqevaika lltapidlen nssivdkevc vnrsflvedp 1141 allylynhlr nrnlkyfigs lnveakiect lilrvtdilc rmgcnylavs lvknwkfier 1201 nsipvqkllk sptkdraysa igamasepis tarmrpslfd kfgspsasdi espnpklpns 1261 llddflqppp nstssnslaq ssssaprsil defvspsysq hkenltpkap ndsvgetdns 1321 enrkdklskd ilddlssqkp qkpkksaitk nllddfv // LOCUS NP_012568 108 aa linear PLN 30-JUN-2025 DEFINITION Pet191p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012568 VERSION NP_012568.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181692.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 108) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08823. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..108 /product="Pet191p" /calculated_mol_wt="12263" Region 4..70 /region_name="Pet191_N" /note="Cytochrome c oxidase assembly protein PET191; pfam10203" /db_xref="CDD:402002" CDS 1..108 /gene="PET191" /locus_tag="YJR034W" /coded_by="NM_001181692.1:1..327" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:18503002]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:8381337|PMID:18503002]" /note="Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery" /db_xref="GeneID:853491" /db_xref="SGD:S000003795" ORIGIN 1 mvasckdqkk avaiclqrsp cvmierhnpq ecldnpelnk dlpelciaqm kafldckrgi 61 vdmtkrftgn aplstgkydq qyenlckgkf dpreemeklk llnsqqkd // LOCUS NP_012569 1085 aa linear PLN 30-JUN-2025 DEFINITION DNA-dependent ATPase RAD26 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012569 VERSION NP_012569.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181693.1 REFERENCE 1 (residues 1 to 1085) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1085) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1085) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1085) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1085) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1085) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1085) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08824. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1085 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1085 /product="DNA-dependent ATPase RAD26" /EC_number="3.6.4.12" /calculated_mol_wt="124397" Region <222..792 /region_name="HepA" /note="Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair]; COG0553" /db_xref="CDD:440319" Region 1019..1080 /region_name="CSB_WHD" /note="winged-helix domain (WHD) found in cockayne syndrome group B (CSB) and similar proteins; cd22254" /db_xref="CDD:439329" CDS 1..1085 /gene="RAD26" /locus_tag="YJR035W" /coded_by="NM_001181693.1:1..3258" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:8702468]" /experiment="EXISTENCE:genetic interaction:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17023424]" /experiment="EXISTENCE:genetic interaction:GO:0006289 nucleotide-excision repair [PMID:17023424]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:32690696]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:32690696|PMID:7957102]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:23991048]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:23991048]" /note="Protein involved in transcription-coupled nucleotide excision repair; repairs UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein" /db_xref="GeneID:853492" /db_xref="SGD:S000003796" ORIGIN 1 medkeqqdna klenneslkd lgvnvlsqss leekiandvt nfsnlqslqq eetrlerskt 61 alqryvnkkn hltrklnntt risvkqnlrd qiknlqsddi ervlkdiddi qsrikelkeq 121 vdqgaenkgs keglqrpget ekeflirtgk itafghkagf sldtanreya kndeqkdedf 181 emateqmven ltdeddnlsd qdyqmsgkes eddeeeendd kilkeledlr frgqpgeakd 241 dgdelyyqer lkkwvkqrsc gsqrssdlpe wrrphpnipd aklnsqfkip geiysllfny 301 qktcvqwlye lyqqncggii gdemglgkti qviafiaalh hsglltgpvl ivcpatvmkq 361 wcnefqhwwp plrtvilhsm gsgmasdqkf kmdendlenl imnskpsdfs yedwknstrt 421 kkalessyhl dklidkvvtd ghilittyvg lrihsdkllk vkwqyavlde ghkirnpdse 481 isltckklkt hnriilsgtp iqnnltelws lfdfifpgkl gtlpvfqqqf vipiniggya 541 natniqvqtg ykcavalrdl ispyllrrvk advakdlpqk kemvlfcklt kyqrskylef 601 lhssdlnqiq ngkrnvlfgi dilrkicnhp dlldrdtkrh npdygdpkrs gkmqvvkqll 661 llwhkqgyka llftqsrqml dileefistk dpdlshlnyl rmdgttnikg rqslvdrfnn 721 esfdvflltt rvgglgvnlt ganriiifdp dwnpstdmqa rerawrigqk revsiyrlmv 781 ggsieekiyh rqifkqfltn riltdpkqkr ffkihelhdl fslggengys teelneevqk 841 htenlknsks eesddfeqlv nlsgvskles fyngkekken skteddrlie gllggesnle 901 tvmshdsvvn shagssssni itkeasrvai eavnalrksr kkitkqyeig tptwtgrfgk 961 agkirkrdpl knkltgsaai lgnitksqke askearqeny ddgitfarsk einsntktle 1021 niraylqkqn nffsssvsil nsigvslsdk edvikvrall ktiaqfdker kgwvldeefr 1081 nnnas // LOCUS NP_012570 892 aa linear PLN 30-JUN-2025 DEFINITION putative E3 ubiquitin-protein ligase HUL4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012570 VERSION NP_012570.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181694.3 REFERENCE 1 (residues 1 to 892) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 892) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 892) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 892) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 892) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 892) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 892) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08825. On Jul 30, 2012 this sequence version replaced NP_012570.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..892 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..892 /product="putative E3 ubiquitin-protein ligase HUL4" /EC_number="2.3.2.26" /calculated_mol_wt="103326" Region 1..892 /region_name="HUL4" /note="Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; COG5021" /db_xref="CDD:227354" CDS 1..892 /gene="HUL4" /locus_tag="YJR036C" /coded_by="NM_001181694.3:1..2679" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:15828860]" /note="Protein with similarity to hect domain E3 ubiquitin-protein ligases; not essential for viability; found in association with Trf4 in TRAMP complex" /db_xref="GeneID:853494" /db_xref="SGD:S000003797" ORIGIN 1 mvslfdklna kkdgrdgsvs kellshsvah tknrlpksgr rtserslaas vkdgscsnsk 61 snkrnssasv sgeedkscli slnclccgvp lrfpasitkf rcsacqvtvi vkepeinsnl 121 essthisctl eglqmvvrrc hddlqrlkkt gildkerkgl ifqpvityll drfhdvsiln 181 rsflvhdggk nikmlnyevl qrfysilsnl ptrkpyysml cccndllkri tinkgenlqi 241 lqyrwlliil niptirtcli rdrksknvfe tqqiravsye lakrcigyls nlstktsqql 301 iqslrrtptd nfsyqveiln lyinfqfsrl lsnelsnrta knnvkpedem rsrlrrhhtt 361 gheflstrpi saqsndkqgs gfthpvnnkm kfkffqyeed whihsaaklt fiyyvantrr 421 ngrgalsiqs fynitldfid ykqdfdhwrg vaqktkmnql ieewgnsttk kcfsfckypf 481 ilslgikisi meyeirrime heaeqaflis ldkgksvdvy fkikvrrdvi shdslrcike 541 hqgdllkslr iefvnepgid agglrkewff lltkslfnpm nglfiyikes srswfaidpp 601 nfdkskgkns qlelyylfgv vmglaifnst ildlqfpkal ykklcsepls fedyselfpe 661 tsrnlikmln ytednfedvf sltfettyrn nnwilndsks skeyvtvelc engrnvpitq 721 snkhefvmkw vefyleksie pqynkfvsgf krvfaecnsi klfnseeler lvcgdeeqtk 781 fdfkslrsvt kyvggfsdds ravcwfweii eswdyplqkk llqfvtasdr ipatgistip 841 fkisllgshd sddlplahtc fneiclwnys skkklelkll wainesegyg fr // LOCUS NP_012573 1121 aa linear PLN 30-JUN-2025 DEFINITION Mlo127p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012573 VERSION NP_012573.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181697.1 REFERENCE 1 (residues 1 to 1121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1121) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08826. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1121 /product="Mlo127p" /calculated_mol_wt="127309" CDS 1..1121 /gene="MLO127" /locus_tag="YJR039W" /coded_by="NM_001181697.1:1..3366" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="Mitochondrial hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:853495" /db_xref="SGD:S000003800" ORIGIN 1 mpagririam tdniivsevd gppdvvkcfi reedglegqs relvvigley idvfegveqd 61 earkklrlrt vgytmaafyf kdhtapnrrf yillkatgrl dfvnldykiv ksletgidqv 121 rsepkfmfqd plrtalvfnl scteiyeist edifcleetd vklsyvtssp ivsidacinf 181 ndfldkdvft lsiltrahne vaykleacvc vfeskpakgt kwqrttnltf veeatvsqvl 241 lksvtnighf vftpwktyfi khalsskqti dgktvdkiyq gpgafgsdnm eriellqpil 301 adttlnhltf tfmtstaili tcrmnailss feddtyiwek alferlping gsshdhylaa 361 ffnekcwilv spkghltvys vrneghsnfv hlgsflckst lysdlignyt kshlscgslh 421 cgqgylclkf rscgdifast cmkllfkskd svprqvystr kgiywadvnn nvyrdserid 481 feingsfiat kdgtllkdnt ivtlvpiqrd necnyayvtk qgylrwsfsk vyyriqntgv 541 dltidncfls aisskgsflt vlvlndeitv fdhcnrlksq kvvfhrlsdl asiflyeyes 601 tvyifmsdte gnlcvmklat feiveevkic kkklqfcevp nsdyffiyta dtiiffkpsk 661 ikgrfkiqev yapcpiscli pgekdgsvvm vtsqgqfydv lvpgdagrat lcskfekvlk 721 tclkfitles ssryvivaal pvanplqdky seiyvydikq fknisafnfs nlnndiesik 781 yenamisdii avpmlkrtet lgkrktsely kevifnscil vslnldsidg idsknmnnll 841 lfsfdeesgf iefvfgintg fsisglhnyy ngcvlvygef vqayqlnysv hdnkfsieqv 901 snrlnisgit itssiffdkr kakmarkqqn igtwvyleem illdvrkgvm rfnvihttdg 961 niekvqlqvq plnlferdli nsitdtgkmf tgaaaitfkn iryllisygd qkltlfslkl 1021 dgeeeiderv yhvaeqvtti nsvrttdsrm stflgestfm plflvstlsn gcyvigilhe 1081 esdislhils ekkavfakrs vqkflgfldp qmddhtvise i // LOCUS NP_012574 779 aa linear PLN 30-JUN-2025 DEFINITION Gef1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012574 VERSION NP_012574.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181698.1 REFERENCE 1 (residues 1 to 779) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 779) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 779) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 779) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08827. Method: conceptual translation. FEATURES Location/Qualifiers source 1..779 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..779 /product="Gef1p" /calculated_mol_wt="87461" Region 83..569 /region_name="ClC_3_like" /note="ClC-3-like chloride channel proteins. This CD includes ClC-3, ClC-4, ClC-5 and ClC-Y1. ClC-3 was initially cloned from rat kidney. Expression of ClC-3 produces outwardly-rectifying Cl currents that are inhibited by protein kinase C activation. It has...; cd03684" /db_xref="CDD:239656" Site order(185..189,228..232,466..470,558) /site_type="active" /note="putative Cl- selectivity filter [active]" /db_xref="CDD:239656" Site 230 /site_type="active" /note="putative pore gating glutamate residue [active]" /db_xref="CDD:239656" Site 287 /site_type="active" /note="putative H+/Cl- coupling transport residue [active]" /db_xref="CDD:239656" Region 586..736 /region_name="CBS_pair_voltage-gated_CLC_euk_bac" /note="Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the voltage gated CLC (chloride channel) in eukaryotes and bacteria; cd04591" /db_xref="CDD:341367" Site order(592,594..596,622..624,715,727,729,731..732,735) /site_type="other" /note="ligand binding site II [chemical binding]" /db_xref="CDD:341367" Region 592..687 /region_name="CBS repeat" /note="CBS repeat [structural motif]" /db_xref="CDD:341367" Site order(622,641,645..646,649,693,715..717,731) /site_type="other" /note="putative ligand binding site I [chemical binding]" /db_xref="CDD:341367" Region 693..735 /region_name="CBS repeat" /note="CBS repeat [structural motif]" /db_xref="CDD:341367" CDS 1..779 /gene="GEF1" /locus_tag="YJR040W" /gene_synonym="CLC" /coded_by="NM_001181698.1:1..2340" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:17662057]" /experiment="EXISTENCE:direct assay:GO:0005247 voltage-gated chloride channel activity [PMID:12074596]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:15710404]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17662057]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15710404]" /experiment="EXISTENCE:direct assay:GO:0005797 Golgi medial cisterna [PMID:9614122]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17662057]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:9614122|PMID:9520490]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9520490]" /note="Voltage-gated chloride channel; localized to the golgi, the endosomal system, and plasma membrane; involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism" /db_xref="GeneID:853497" /db_xref="SGD:S000003801" ORIGIN 1 mpttyvpinq pigdgedvid tnrftnipet qnfdqfvtid kiaeenrpls vdsdreflns 61 kyrhyreviw draktfitls staivigcia gflqvftetl vnwktghcqr nwllnksfcc 121 ngvvnevtst snlllkrqef eceaqglwia wkghvspfii fmllsvlfal istllvkyva 181 pmatgsgise ikvwvsgfey nkeflgfltl viksvalpla issglsvgke gpsvhyatcc 241 gylltkwllr dtltyssqye yitaasgagv avafgapigg vlfgleeias anrfnsstlw 301 ksyyvalvai ttlkyidpfr ngrvilfnvt ydrdwkvqei pifialgifg glygkyiskw 361 ninfihfrkm ylsswpvqev lflatltali syfneflkld mtesmgilfh ecvkndntst 421 fshrlcqlde nthafeflki ftslcfatvi rallvvvsyg arvpagifvp smavgatfgr 481 avsllverfi sgpsvitpga yaflgaaatl sgitnltltv vvimfeltga fmyiiplmiv 541 vaitriilst sgisggiadq mimvngfpyl edeqdeeeee tlekytaeql mssklitine 601 tiylselesl lydsaseysv hgfpitkded kfekekrcig yvlkrhlask immqsvnstk 661 aqttlvyfnk sneelghren cigfkdimne spisvkkavp vtllfrmfke lgcktiivee 721 sgilkglvta kdilrfkrik yrevhgakft ynealdrrcw svihfiikrf ttnrngnvi // LOCUS NP_012575 1174 aa linear PLN 30-JUN-2025 DEFINITION ribosome biogenesis protein URB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012575 VERSION NP_012575.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181699.3 REFERENCE 1 (residues 1 to 1174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1174) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08828. On Jul 30, 2012 this sequence version replaced NP_012575.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1174 /product="ribosome biogenesis protein URB2" /calculated_mol_wt="134987" Region 964..1174 /region_name="Urb2" /note="Urb2/Npa2 family; pfam10441" /db_xref="CDD:431289" CDS 1..1174 /gene="URB2" /locus_tag="YJR041C" /gene_synonym="NPA2" /coded_by="NM_001181699.3:1..3525" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15226434|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0016072 rRNA metabolic process [PMID:15242642]" /experiment="EXISTENCE:physical interaction:GO:0042254 ribosome biogenesis [PMID:15226434]" /note="Protein required for normal metabolism of the rRNA primary transcript; nucleolar protein; proposed to be involved in ribosome biogenesis" /db_xref="GeneID:853498" /db_xref="SGD:S000003802" ORIGIN 1 mgdlteelsi pdnaqdlskl lrststkphq iaeivskfdk letyfpkkei fvldllidrl 61 nngnlddfkt sehtwiiftr lldaindpis ikkllkklkt vpvmirtffl wpkdklltrs 121 vsfikaffai ndylivnfsv eesfqlleha inglsscptt dfalsylqda cnlthvdnit 181 ttdnkiatcy ckhmllpslr yfaqtknsas snqsfirlsh fmgkfllqpr idymklnkkf 241 vqenaseitd dmayyyfatf vtflskdnfa qleviftilg akkpslecrf lnllseskkt 301 vsqefleall lemlastdes gvlslipiil kldievaikh ifrlleliql enlndplfss 361 hiwdliiqsh anarelsdff akineycsrk gpdsyflinh payvksitkq lftlsslqwk 421 nllqalldqv nhdstnrvpl yliriclegl segasratld evkpilsqvf tlesfnnslq 481 wdlkyhimev yddivpaeel ekidyvlssn ifdttsadve elffycfklr eyisfdlsda 541 kkkfmrhfei ldeerksnls ysvvskfatl vnnnftreqi sslidsllln stnlssllkn 601 ddifeetnit yalinklass yhqtfaleal iqipiqcink nvrvalinnl tcesfcldsa 661 trecllhlls sptfksniet nfyelcekti mspemaiset gdekkeiedk isifekvwtn 721 hlsqakepvs ekflesgydi vkqsmslsng dskliiagft iakflkpdnk hrdiqgmais 781 yavkilenys enfesetipl frismstlyk iittgqgdis khksrildif skimlryhsk 841 kvyhapeeqe mflvhsllte nkleyifaey lniehtdkcd salgfclees lkqgpdafnr 901 llwnsaksfs tisqpcaekf vrvfiimskr iardnnlghh lfvialleay tycdiekfgy 961 ksylllfnai keflvskpwl fsqyciemll pfclktlafi vnhestdein egfiniievi 1021 dhmllvhrfk fsnrhhlfns vlcqileiia ihdgtlcans adavarlitn ycepynvsna 1081 qngqknnlss kislikqsir knvlvvltky iqlsittqfs lnikkslqpg ihaifdilsq 1141 nelnqlnafl dtpgkqyfka lylqykkvgk wred // LOCUS NP_012576 744 aa linear PLN 30-JUN-2025 DEFINITION Nup85p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012576 VERSION NP_012576.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181700.1 REFERENCE 1 (residues 1 to 744) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 744) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 744) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 744) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 744) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08829. Method: conceptual translation. FEATURES Location/Qualifiers source 1..744 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..744 /product="Nup85p" /calculated_mol_wt="84767" Region 89..697 /region_name="Nucleopor_Nup85" /note="Nup85 Nucleoporin; pfam07575" /db_xref="CDD:400113" CDS 1..744 /gene="NUP85" /locus_tag="YJR042W" /gene_synonym="RAT9" /coded_by="NM_001181700.1:1..2235" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:11823431|PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:8816998|PMID:8565072]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:22331846]" /experiment="EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:8816998|PMID:8565072]" /note="Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP85 aka NUP75" /db_xref="GeneID:853499" /db_xref="SGD:S000003803" ORIGIN 1 mtiddsnrll mdvdqfdfld dgtaqlsnnk tdeeeqlykr dpvsgailvp mtvndqpiek 61 ngdkmplkfk lgplsyqnma fitakdkykl ypvriprldt skefsayvsg lfeiyrdlgd 121 drvfnvptig vvnsnfakeh natvnlamea ilnelevfig rvkdqdgrvn rfyeleeslt 181 vlnclrtmyf ildgqdveen rsefieslln winrsdgepd eeyieqvfsv kdstagkkvf 241 etqyfwklln qlvlrgllsq aigciersdl lpylsdtcav sfdavsdsie llkqypkdss 301 stfrewknlv lklsqafgss atdisgelrd yiedfllvig gnqrkilqys rtwyesfcgf 361 llyyipslel saeylqmsle anvvditndw eqpcvdiisg kihsilpvme sldsctaaft 421 amiceakgli enifegekns ddysnednem ledlfsyrng masymlnsfa felcslgdke 481 lwpvaiglia lsatgtrsak kmviaellph ypfvtnddie wmlsicvewr lpeiakeiyt 541 tlgnqmlsah niiesianfs ragkyelvks yswllfeasc megqklddpv lnaivsknsp 601 aeddviipqd ildcvvtnsm rqtlapyavl sqfyelrdre dwgqalrlll lliefpylpk 661 hylvllvakf lypifllddk klmdedsvat vievietkwd dadekssnly etiieadksl 721 pssmatllkn lrkklnfklc qafm // LOCUS NP_012577 350 aa linear PLN 30-JUN-2025 DEFINITION DNA polymerase delta subunit POL32 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012577 VERSION NP_012577.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181701.1 REFERENCE 1 (residues 1 to 350) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 350) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 350) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 350) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08830. Method: conceptual translation. FEATURES Location/Qualifiers source 1..350 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..350 /product="DNA polymerase delta subunit POL32" /calculated_mol_wt="40179" Region <125..348 /region_name="CDC27" /note="DNA polymerase subunit Cdc27; pfam09507" /db_xref="CDD:462819" CDS 1..350 /gene="POL32" /locus_tag="YJR043C" /gene_synonym="REV5" /coded_by="NM_001181701.1:1..1053" /experiment="EXISTENCE:direct assay:GO:0000510 H3-H4 histone complex chaperone activity [PMID:38713623]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:18635534]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006278 RNA-templated DNA biosynthetic process [PMID:17429354]" /experiment="EXISTENCE:direct assay:GO:0016035 zeta DNA polymerase complex [PMID:23066099|PMID:22711820]" /experiment="EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:16837458]" /experiment="EXISTENCE:mutant phenotype:GO:0000510 H3-H4 histone complex chaperone activity [PMID:38713623]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:17671506]" /experiment="EXISTENCE:mutant phenotype:GO:0006277 DNA amplification [PMID:23271978]" /experiment="EXISTENCE:mutant phenotype:GO:0042276 error-prone translesion synthesis [PMID:17681555]" /note="Third subunit of DNA polymerase delta; involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; parental H3-H4 histone chaperone that mediates transfer of parental histones to the lagging strand via Pol1p during DNA replication; forms a complex with Rev3p, Rev7p and Pol31p; interacts with Hys2p, PCNA (Pol30p), and Pol1p" /db_xref="GeneID:853500" /db_xref="SGD:S000003804" ORIGIN 1 mdqkasyfin eklftevkpv lftdlihhlk igpsmakklm fdyykqttna kyncvviccy 61 kdqtikiihd lsnipqqdsi idcfiyafnp mdsfipyydi idqkdcltik nsyelkvses 121 skiiertktl eekskplvrp tarskttpee ttgrkskskd mglrstalla kmkkdrddke 181 tsrqnelrkr keenlqkink qnpereaqmk elnnlfvedd ldteevnggs kpnspketds 241 ndkdknnddl edllettaed slmdvpkiqq tkpsetehsk epkseeepss fidedgyivt 301 krpatstppr kpspvvkral ssskkqetps snkrlkkqgt lesffkrkak // LOCUS NP_012578 140 aa linear PLN 30-JUN-2025 DEFINITION Vps55p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012578 VERSION NP_012578.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181702.3 REFERENCE 1 (residues 1 to 140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 140) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08831. On Jul 30, 2012 this sequence version replaced NP_012578.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..140 /product="Vps55p" /calculated_mol_wt="15532" Region 12..131 /region_name="Vps55" /note="Vacuolar protein sorting 55; pfam04133" /db_xref="CDD:461188" CDS 1..140 /gene="VPS55" /locus_tag="YJR044C" /coded_by="NM_001181702.3:1..423" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:12006663]" /experiment="EXISTENCE:direct assay:GO:0034424 Vps55/Vps68 complex [PMID:18216282]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18216282]" /experiment="EXISTENCE:physical interaction:GO:0034424 Vps55/Vps68 complex [PMID:18216282]" /note="Late endosomal protein involved in late endosome to vacuole transport; functional homolog of human obesity receptor gene-related protein (OB-RGRP)" /db_xref="GeneID:853502" /db_xref="SGD:S000003805" ORIGIN 1 mmefkvsplt kiislsgfla lgfllvilsc alfhnyyplf dilifllapi pntifnagnk 61 yhtsdfmsds sntgqdlahf ltgmlvtsgi alpvvfyhcq lighlscimc miggliiyss 121 ivifkwffkk dfneddslfg // LOCUS NP_012579 654 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family ATPase SSC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012579 VERSION NP_012579.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181703.1 REFERENCE 1 (residues 1 to 654) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 654) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 654) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 654) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08832. Method: conceptual translation. FEATURES Location/Qualifiers source 1..654 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..654 /product="Hsp70 family ATPase SSC1" /EC_number="3.6.4.10" /calculated_mol_wt="70497" Region 30..633 /region_name="dnaK" /note="molecular chaperone DnaK; Provisional; PRK00290" /db_xref="CDD:234715" CDS 1..654 /gene="SSC1" /locus_tag="YJR045C" /gene_synonym="ENS1" /coded_by="NM_001181703.1:1..1965" /experiment="EXISTENCE:direct assay:GO:0001405 PAM complex, Tim23 associated import motor [PMID:14638855|PMID:14517234]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:11914276|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7935837]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:11096111]" /experiment="EXISTENCE:direct assay:GO:0030150 protein import into mitochondrial matrix [PMID:8654364]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:10464305]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9973563]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:10779357]" /experiment="EXISTENCE:mutant phenotype:GO:0042026 protein refolding [PMID:16460754]" /experiment="EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:8408192]" /note="Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication" /db_xref="GeneID:853503" /db_xref="SGD:S000003806" ORIGIN 1 mlaaknilnr sslsssfria trlqstkvqg svigidlgtt nsavaimegk vpkiienaeg 61 srttpsvvaf tkegerlvgi pakrqavvnp entlfatkrl igrrfedaev qrdikqvpyk 121 ivkhsngdaw veargqtysp aqiggfvlnk mketaeaylg kpvknavvtv payfndsqrq 181 atkdagqivg lnvlrvvnep taaalaygle ksdskvvavf dlgggtfdis ildidngvfe 241 vkstngdthl ggedfdiyll reivsrfkte tgidlendrm aiqrireaae kakielsstv 301 steinlpfit adasgpkhin mkfsraqfet ltaplvkrtv dpvkkalkda glstsdisev 361 llvggmsrmp kvvetvkslf gkdpskavnp deavaigaav qgavlsgevt dvllldvtpl 421 slgietlggv ftrliprntt iptkksqifs taaagqtsve irvfqgerel vrdnklignf 481 tlagippapk gvpqievtfd idadgiinvs ardkatnkds sitvagssgl seneieqmvn 541 daekfksqde arkqaietan kadqlandte nslkefegkv dkaeaqkvrd qitslkelva 601 rvqggeevna eelktkteel qtssmklfeq lykndsnnnn nnngnnaesg etkq // LOCUS NP_012580 604 aa linear PLN 30-JUN-2025 DEFINITION Tah11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012580 VERSION NP_012580.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181704.1 REFERENCE 1 (residues 1 to 604) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 604) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 604) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 604) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08833. Method: conceptual translation. FEATURES Location/Qualifiers source 1..604 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..604 /product="Tah11p" /calculated_mol_wt="68274" Region 482..575 /region_name="Cdt1_c" /note="The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase; cl14631" /db_xref="CDD:472696" CDS 1..604 /gene="TAH11" /locus_tag="YJR046W" /gene_synonym="CDT1; SID2" /coded_by="NM_001181704.1:1..1815" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11836525]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11836525]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:11967159]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0005656 nuclear pre-replicative complex [PMID:11967159]" /note="DNA replication licensing factor; required for pre-replication complex assembly" /db_xref="GeneID:853504" /db_xref="SGD:S000003807" ORIGIN 1 msgtansrrk evlrvpvidl nrvsdeeqll pvvraillqh dtfllknyan kavldallag 61 lttkdlpdts qgfdanftgt lpleddvwle qyifdtdpql rfdrkcrnes lcsiysrlfk 121 lglffaqlcv ksvvssaelq dcistshyat kltryfndng sthdgadaga tvlptgddfq 181 ylferdyvtf lptgvltifp cakairykps tmattdnswv sidepdcllf htgtllarws 241 qgmhttsplq idpranivsl tiwpplttpi sskgegtian hlleqqikaf pkvaqqyypr 301 elsilrlqda mkfvkelftv cetvlslnal srstgvppel hvllpqissm mkrkivqddi 361 lklltiwsda yvvelnsrge ltmnlpkrdn lttltnksrt lafveraesw yqqviaskde 421 imtdvpafki nkrrsssnsk tvlsskvqtk ssnanalnns rylanskenf mykekmpdsq 481 anlmdrlrer errsaallsq rqkryqqfla mkmtqvfdil fsltrgqpyt etylsslivd 541 slqdsnnpig tkeaseilag lqgilpmdis vhqvdgglkv yrwnsldknr fskllqihks 601 kqqd // LOCUS NP_012581 157 aa linear PLN 30-JUN-2025 DEFINITION translation elongation factor eIF-5A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012581 VERSION NP_012581.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181705.3 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 157) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08834. On Jul 30, 2012 this sequence version replaced NP_012581.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..157 /product="translation elongation factor eIF-5A" /calculated_mol_wt="17000" Region 1..154 /region_name="PLN03107" /note="eukaryotic translation initiation factor 5A; Provisional" /db_xref="CDD:215580" CDS 1..157 /gene="ANB1" /locus_tag="YJR047C" /gene_synonym="HYP1; TIF51B" /coded_by="NM_001181705.3:1..474" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:27196944]" /experiment="EXISTENCE:genetic interaction:GO:0006452 translational frameshifting [PMID:19424157]" /experiment="EXISTENCE:genetic interaction:GO:0045901 positive regulation of translational elongation [PMID:19424157]" /note="Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant" /db_xref="GeneID:853506" /db_xref="SGD:S000003808" ORIGIN 1 msdeehtfen adagasatyp mqcsalrkng fvvikgrpck ivdmstsktg khghakvhlv 61 tldiftgkkl edlspsthnl evpfvkrsey qlldiddgyl slmtmdgetk ddvkapegel 121 gdsmqaafde gkdlmvtiis amgeeaaisf keaprsd // LOCUS NP_012582 109 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c isoform 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012582 VERSION NP_012582.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181706.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 109) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08835. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..109 /product="cytochrome c isoform 1" /calculated_mol_wt="12051" Region 7..105 /region_name="Cyc7" /note="Cytochrome c2 [Energy production and conversion]; COG3474" /db_xref="CDD:442697" CDS 1..109 /gene="CYC1" /locus_tag="YJR048W" /coded_by="NM_001181706.1:1..330" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:9866716]" /experiment="EXISTENCE:direct assay:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:7851399]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:7851399]" /experiment="EXISTENCE:direct assay:GO:0009055 electron transfer activity [PMID:18975895|PMID:7851399]" /experiment="EXISTENCE:direct assay:GO:1901612 cardiolipin binding [PMID:30182710]" /note="Cytochrome c, isoform 1; also known as iso-1-cytochrome c; electron carrier of mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration; CYC1 has a paralog, CYC7, that arose from the whole genome duplication; human homolog CYC1 can complement yeast null mutant; mutations in human CYC1 cause insulin-responsive hyperglycemia" /db_xref="GeneID:853507" /db_xref="SGD:S000003809" ORIGIN 1 mtefkagsak kgatlfktrc lqchtvekgg phkvgpnlhg ifgrhsgqae gysytdanik 61 knvlwdennm seyltnpkky ipgtkmafgg lkkekdrndl itylkkace // LOCUS NP_012583 530 aa linear PLN 30-JUN-2025 DEFINITION NADH/NAD(+) kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012583 VERSION NP_012583.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181707.1 REFERENCE 1 (residues 1 to 530) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 530) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 530) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 530) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08836. Method: conceptual translation. FEATURES Location/Qualifiers source 1..530 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..530 /product="NADH/NAD(+) kinase" /EC_number="2.7.1.23" /calculated_mol_wt="59338" Region <115..451 /region_name="DAGK_cat" /note="Diacylglycerol kinase catalytic domain; cl01255" /db_xref="CDD:445337" CDS 1..530 /gene="UTR1" /locus_tag="YJR049C" /coded_by="NM_001181707.1:1..1593" /experiment="EXISTENCE:direct assay:GO:0003951 NAD+ kinase activity [PMID:11425472]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006741 NADP+ biosynthetic process [PMID:15978040|PMID:11425472]" /experiment="EXISTENCE:direct assay:GO:0042736 NADH kinase activity [PMID:15978040]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:8662826]" /note="ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication" /db_xref="GeneID:853508" /db_xref="SGD:S000003810" ORIGIN 1 mkendmnngv dkwvneedgr ndhhnnnnnl mkkammnneq idrtqdidna kemlrkisse 61 sssrrsslln kdsslvngna nsgggtsing trgsskssnt hfqyastayg vrmlskdisn 121 tkveldvenl mivtklndvs lyfltrelve wvlvhfprvt vyvdselkns kkfaagelce 181 dskcresrik ywtkdfireh dvffdlvvtl ggdgtvlfvs sifqrhvppv msfslgslgf 241 ltnfkfehfr edlprimnhk iktnlrlrle ctiyrrhrpe vdpntgkkic vveklsthhi 301 lnevtidrgp spflsmlely gdgslmtvaq adgliaatpt gstayslsag gslvcptvna 361 ialtpicpha lsfrpiilpe sinlkvkvsm ksrapawaaf dgkdrielqk gdfiticasp 421 yafptveasp definsisrq lnwnvreqqk sfthilsqkn qekyaheank vrnqaeplev 481 irdkyslead atkennngsd desddesvnc eacklkpssv pkpsqarfsv // LOCUS NP_012584 235 aa linear PLN 30-JUN-2025 DEFINITION Isy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012584 VERSION NP_012584.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181708.3 REFERENCE 1 (residues 1 to 235) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 235) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 235) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 235) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 235) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08837. On Jul 30, 2012 this sequence version replaced NP_012584.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..235 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..235 /product="Isy1p" /calculated_mol_wt="27893" Region 1..232 /region_name="Isy1" /note="Isy1-like splicing family; pfam06246" /db_xref="CDD:461860" CDS 1..235 /gene="ISY1" /locus_tag="YJR050W" /gene_synonym="NTC30; UTR3" /coded_by="NM_001181708.3:1..708" /experiment="EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:11018040]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:10094305|PMID:11018040]" /experiment="EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:10094305]" /experiment="EXISTENCE:direct assay:GO:0071014 post-mRNA release spliceosomal complex [PMID:10094305]" /experiment="EXISTENCE:direct assay:GO:0071020 post-spliceosomal complex [PMID:10094305]" /experiment="EXISTENCE:genetic interaction:GO:0000384 first spliceosomal transesterification activity [PMID:16103217]" /experiment="EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:10094305]" /experiment="EXISTENCE:mutant phenotype:GO:0000389 mRNA 3'-splice site recognition [PMID:16103217]" /note="Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs; interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles" /db_xref="GeneID:853509" /db_xref="SGD:S000003811" ORIGIN 1 msrnvdkans vlvrfqeqqa esaggykdys ryqrprnvsk vksikeanew krqvskeikq 61 kstriydpsl nemqiaelnd elnnlfkewk rwqwhidhtl mekktkrkrl edshvlmnsg 121 klingkryfg ralelpevke wlkqsqrqnd ggsintkcip kdrndfyyhg kvtaaltefe 181 anwtsilkah ynvpvnedee emsrqtqeih vptladmehw lvqrrkkklm delnl // LOCUS NP_012585 501 aa linear PLN 30-JUN-2025 DEFINITION fumarate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012585 VERSION NP_012585.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181709.1 REFERENCE 1 (residues 1 to 501) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 501) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 501) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 501) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08838. Method: conceptual translation. FEATURES Location/Qualifiers source 1..501 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..501 /product="fumarate reductase" /EC_number="1.3.1.6" /calculated_mol_wt="54934" Region 36..495 /region_name="flavo_cyto_c" /note="flavocytochrome c; TIGR01813" /db_xref="CDD:273816" CDS 1..501 /gene="OSM1" /locus_tag="YJR051W" /coded_by="NM_001181709.1:1..1506" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:9587404|PMID:25378625|PM ID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:25378625]" /experiment="EXISTENCE:direct assay:GO:0016156 fumarate reductase (NADH) activity [PMID:9587404]" /experiment="EXISTENCE:mutant phenotype:GO:0034975 protein folding in endoplasmic reticulum [PMID:25378625]" /experiment="EXISTENCE:mutant phenotype:GO:0046443 FAD metabolic process [PMID:17345583]" /note="Fumarate reductase, catalyzes the reduction of fumarate to succinate; required for the reoxidation of intracellular NADH under anaerobic conditions; acts as electron acceptor in mitochondrial intermembrane space; has two translation start sites, one at the annotated start codon which produces an ER-targeted form required for anaerobic growth, and one at codon 32 which produces a mitochondrially-targeted form; OSM1 has a paralog, FRD1, that arose from the whole genome duplication" /db_xref="GeneID:853510" /db_xref="SGD:S000003812" ORIGIN 1 mirsvrrvfi yvsifvliiv lkrtlsgtdq tsmkqpvvvi gsglagltts nrliskyrip 61 vvlldkaasi ggnsikassg ingahtdtqq nlkvmdtpel flkdtlhsak grgvpslmdk 121 ltkesksair wlqtefdlkl dllaqlgghs vprthrssgk lppgfeivqa lskklkdiss 181 kdsnlvqiml nsevvdield nqghvtgvvy mdengnrkim kshhvvfcsg gfgyskemlk 241 eyspnlihlp ttngkqttgd gqkilsklga elidmdqvqv hptgfidpnd rennwkflaa 301 ealrglggil lhpttgrrft nelstrdtvt meiqskcpkn dnrallvmsd kvyenytnni 361 nfymsknlik kvsindlirq ydlqttasel vtelksysdv ntkdtfdrpl iinafdkdis 421 testvyvgev tpvvhftmgg vkineksqvi kknsesvlsn gifaagevsg gvhganrlgg 481 ssllecvvfg ktaadniakl y // LOCUS NP_012586 565 aa linear PLN 30-JUN-2025 DEFINITION UV-damaged DNA-binding protein RAD7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012586 VERSION NP_012586.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181710.1 REFERENCE 1 (residues 1 to 565) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 565) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 565) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 565) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08839. Method: conceptual translation. FEATURES Location/Qualifiers source 1..565 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..565 /product="UV-damaged DNA-binding protein RAD7" /calculated_mol_wt="63647" Region 228..440 /region_name="AMN1" /note="Antagonist of mitotic exit network protein 1; cd09293" /db_xref="CDD:187754" Region 236..261 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 262..287 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 288..340 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 342..365 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 368..397 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 398..426 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 428..455 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 456..475 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 484..507 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 508..533 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" CDS 1..565 /gene="RAD7" /locus_tag="YJR052W" /coded_by="NM_001181710.1:1..1698" /experiment="EXISTENCE:direct assay:GO:0000113 nucleotide-excision repair factor 4 complex [PMID:9497356]" /experiment="EXISTENCE:direct assay:GO:0000715 nucleotide-excision repair, DNA damage recognition [PMID:15177043]" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:9497356]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:16675952]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:9497356]" /experiment="EXISTENCE:direct assay:GO:0008104 intracellular protein localization [PMID:15226437]" /experiment="EXISTENCE:direct assay:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:16675952]" /experiment="EXISTENCE:mutant phenotype:GO:0000715 nucleotide-excision repair, DNA damage recognition [PMID:15177043]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:16675952]" /note="Nucleotide excision repair (NER) protein; binds damaged DNA during NER; binds DNA in an ATP-dependent manner (with Rad16p) during NER; required for repair of non-transcribed chromatin; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex" /db_xref="GeneID:853512" /db_xref="SGD:S000003813" ORIGIN 1 myrsrnrpkr ggenevkgpn saltqflree gisaenikqk wyqrqskkqe datdekkgka 61 eddsftaeis rvvedeeide igtgsgtete raqvsydarm klvpadsdee eyetshisdt 121 pvslssandr esltkkrqnt akiiqnrrrk rkraadlldr rvnkvsslqs lcitkiseni 181 skwqkeades sklvfnklrd vlggvstanl nnlakalskn ralndhtlql flktdlkrlt 241 fsdcskisfd gyktlaifsp hltelslqmc gqlnheslly iaeklpnlks lnldgpflin 301 edtwekffvi mkgrleefhi snthrftdks lsnllincgs tlvslglsrl dsisnyallp 361 qylvndefhs lcieypfnee dvndeiiinl lgqigrtlrk lvlngcidlt dsmiinglta 421 fipekcplev lsleesdqit tdslsyffsk velnnliecs frrclqlgdm aiielllnga 481 rdslrslnln slkeltkeaf valacpnlty ldlgfvrcvd dsviqmlgeq npnltvidvf 541 gdnlvtekat mrpgltligr qsdsi // LOCUS NP_012587 574 aa linear PLN 30-JUN-2025 DEFINITION Bfa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012587 VERSION NP_012587.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181711.3 REFERENCE 1 (residues 1 to 574) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 574) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 574) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 574) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08840. On Jul 30, 2012 this sequence version replaced NP_012587.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..574 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..574 /product="Bfa1p" /calculated_mol_wt="65956" CDS 1..574 /gene="BFA1" /locus_tag="YJR053W" /gene_synonym="IBD1" /coded_by="NM_001181711.3:1..1725" /experiment="EXISTENCE:direct assay:GO:0005092 GDP-dissociation inhibitor activity [PMID:19948498]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:18667533|PMID:12048186|PMID:16682821]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10220406|PMID:15147270]" /experiment="EXISTENCE:direct assay:GO:1990334 Bfa1-Bub2 complex [PMID:25658911]" /experiment="EXISTENCE:mutant phenotype:GO:0001100 negative regulation of exit from mitosis [PMID:18667533|PMID:15147270]" /experiment="EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:16039591]" /experiment="EXISTENCE:physical interaction:GO:1990334 Bfa1-Bub2 complex [PMID:11493673]" /note="Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p; contributes to GAP activity, inactivating Tem1 by stimulating GTP hydrolysis following damage or misalignment of the mitotic spindle; functions as a guanine-nucleotide exchange inhibitor (GDI) for Tem1p; involved in multiple cell cycle checkpoint pathways that control mitotic exit; required when telomeres are damaged, but not for all types of chromosomal DNA damage; phosphorylated by the Polo-like kinase Cdc5p" /db_xref="GeneID:853513" /db_xref="SGD:S000003814" ORIGIN 1 msirpltlng ldepetsfee lnttlprfqs hetltleenv pplststyip ppssvgtsdt 61 gtvfsnstsa fwsnkqaddd qdmevdqdde flndfqefqn kkddfddaik tnfhlrngcr 121 tgpfkndifa eefdrklsle dkprlkqprs mmelkpkrkl snsvtsrnlr sgnsvrfkks 181 mpnlalvnpa ireeeedeer eredqrefny kidndtqdti lakfssddeg dfltgfeele 241 geaidetiss ndkesadhpr flkksssslp lkispaqydi vkhdelltpg lhrrqrdwnt 301 qqeldsfkek rsvrhcsnqn vqlngpakik tikqqidhnt pmkkgsmiyn pktmkwegne 361 nvlskfsdvd tanrkallik nklqrdadsk kqkysdlqha ratsrnqkvi gnmildeqnl 421 rwvsvseeea dpfagipein lppvgksmkk rssspflrsk sqvntpfvsn dndgvyqsta 481 aqarlrkyhs mrtlngttet peisstfhls sralekfyhe enrwckklas wfiprdetii 541 svdeetimde stvnskrksy myeirnmvin stkd // LOCUS NP_012588 497 aa linear PLN 30-JUN-2025 DEFINITION Kch1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012588 VERSION NP_012588.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181712.1 REFERENCE 1 (residues 1 to 497) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 497) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 497) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 497) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08841. Method: conceptual translation. FEATURES Location/Qualifiers source 1..497 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..497 /product="Kch1p" /calculated_mol_wt="57386" Region 14..266 /region_name="KCH" /note="Fungal potassium channel; pfam16944" /db_xref="CDD:435670" CDS 1..497 /gene="KCH1" /locus_tag="YJR054W" /coded_by="NM_001181712.1:1..1494" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23204190]" /experiment="EXISTENCE:direct assay:GO:0005937 mating projection [PMID:23204190]" /experiment="EXISTENCE:direct assay:GO:0015079 potassium ion transmembrane transporter activity [PMID:23204190]" /experiment="EXISTENCE:direct assay:GO:0071805 potassium ion transmembrane transport [PMID:23204190]" /note="Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; localized to sites of polarized growth; member of a fungal-specific gene family; potential Cdc28p substrate; KCH1 has a paralog, PRM6, that arose from the whole genome duplication" /db_xref="GeneID:853514" /db_xref="SGD:S000003815" ORIGIN 1 mfnhdwkysi nsktfadlni elfrnhkfkt vlnyiigvvg wnglklalfv sdiytcikll 61 afnswsnnii kpylpfkisk wlfsgcilas ivlliweaia gmriyktgni sltyvnnfsr 121 nlnsvlnysk fcvynmierk gfrqkmtfft ffqlkdcirl iftdtprqvi ngltlwsvlv 181 tvnknedlgd lesftglink iknigqtnhe eavilslmlf sfiiwalfvf kfllavicsi 241 fvyykiindq eysglreyic vtvsenvdel verqrkkend dtiyktglle sqtfddfkev 301 enkietsfnd tsyasnndsm ielierrpey ksqdvcgpip tmkktetmes fvdngnpqyt 361 trfsaildsp yinsyesndi kkakiqsrsv ntpkyedlss sdifnkihsa gqlksttsme 421 fhgpldsmpn ttnnirnfns nssrprpppl qtkssinska dsndngriyt pmkayfrepd 481 lprkgllede drtynyt // LOCUS NP_012589 164 aa linear PLN 30-JUN-2025 DEFINITION Hit1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012589 VERSION NP_012589.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181713.1 REFERENCE 1 (residues 1 to 164) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 164) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 164) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 164) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08842. Method: conceptual translation. FEATURES Location/Qualifiers source 1..164 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..164 /product="Hit1p" /calculated_mol_wt="18245" Region 7..44 /region_name="zf-HIT_ZNHIT2-3" /note="zinc finger HIT (zf-HIT) found in zinc finger HIT domain-containing protein 2 (ZNHIT2), 3 (ZNHIT3) and similar proteins; cd23024" /db_xref="CDD:467796" Site order(8,11,20,23,28,32,41) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:467796" Region 79..159 /region_name="Hit1_C" /note="Hit1 C-terminal; pfam18268" /db_xref="CDD:408083" CDS 1..164 /gene="HIT1" /locus_tag="YJR055W" /coded_by="NM_001181713.1:1..495" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:25170085]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:25170085]" /note="Protein involved in C/D snoRNP assembly; critical for formation of small nucleolar ribonucleoprotein complexes that are required for rRNA processing and 2'-O-methylation; regulates abundance of Rsa1p; required for growth at high temperature; mutations in human homolog ZNHIT3 cause PEHO syndrome, a ribosomopathy characterized by extreme cerebellar atrophy" /db_xref="GeneID:853516" /db_xref="SGD:S000003816" ORIGIN 1 mvssavkcgi crgvdgkykc pkcgvrycsl kcykdaakhv hkeseqprag teanvevvnn 61 dkiinsslam nktlktkafd diyqnsaelq ellkyntvkf hlakvyrils stvndgssgk 121 mnsdlqkela vnylntlryg gihyneaiee fcqilldkln avkk // LOCUS NP_012590 236 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR056C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012590 VERSION NP_012590.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181714.3 REFERENCE 1 (residues 1 to 236) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 236) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 236) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 236) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08843. On Jul 30, 2012 this sequence version replaced NP_012590.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..236 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..236 /product="uncharacterized protein" /calculated_mol_wt="27230" Region <27..212 /region_name="DUF4588" /note="Domain of unknown function (DUF4588); pfam15251" /db_xref="CDD:464591" CDS 1..236 /locus_tag="YJR056C" /coded_by="NM_001181714.3:1..711" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:853518" /db_xref="SGD:S000003817" ORIGIN 1 meqmhsless lppeqpptkq aieslnlels qefklaanav trlyrvanek nsltkhqgyl 61 tclddilcal dsnvtadelr awcykrrndi lsnsqdksln pvkererkln kfsenqhren 121 eahkepfekd savkynfsfn esngdlsnin eniapkfrls mpplsvehpp rnasrikswk 181 artinhgrgd trnlnditgl ghererdren thyekkpkld sdsevdirsf rqdmdl // LOCUS NP_012591 216 aa linear PLN 30-JUN-2025 DEFINITION bifunctional thymidylate/uridylate kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012591 VERSION NP_012591.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181715.1 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 216) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08844. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..216 /product="bifunctional thymidylate/uridylate kinase" /EC_number="2.7.4.9" /calculated_mol_wt="24556" Region 3..206 /region_name="NK" /note="Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; cl17190" /db_xref="CDD:450170" Site order(19,69,73,93..94,102,144) /site_type="active" /note="TMP-binding site [active]" /db_xref="CDD:238835" Site order(20,140,185) /site_type="other" /note="ATP-binding site [chemical binding]" /db_xref="CDD:238835" CDS 1..216 /gene="CDC8" /locus_tag="YJR057W" /coded_by="NM_001181715.1:1..651" /experiment="EXISTENCE:direct assay:GO:0004550 nucleoside diphosphate kinase activity [PMID:19540237]" /experiment="EXISTENCE:direct assay:GO:0004798 dTMP kinase activity [PMID:19540237|PMID:6094555|PMID:6088527]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:6094555]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:6094555]" /experiment="EXISTENCE:direct assay:GO:0006227 dUDP biosynthetic process [PMID:6094555]" /experiment="EXISTENCE:direct assay:GO:0006233 dTDP biosynthetic process [PMID:6094555|PMID:6088527|PMID:19540237]" /experiment="EXISTENCE:direct assay:GO:0006235 dTTP biosynthetic process [PMID:19540237]" /experiment="EXISTENCE:direct assay:GO:0120136 dUMP kinase activity [PMID:6094555]" /experiment="EXISTENCE:genetic interaction:GO:0004798 dTMP kinase activity [PMID:6091111]" /experiment="EXISTENCE:genetic interaction:GO:0006233 dTDP biosynthetic process [PMID:6091111]" /experiment="EXISTENCE:mutant phenotype:GO:0004550 nucleoside diphosphate kinase activity [PMID:19540237]" /experiment="EXISTENCE:mutant phenotype:GO:0004798 dTMP kinase activity [PMID:6088527|PMID:6091111|PMID:19540237]" /experiment="EXISTENCE:mutant phenotype:GO:0006233 dTDP biosynthetic process [PMID:6088527|PMID:19540237|PMID:6091111]" /experiment="EXISTENCE:mutant phenotype:GO:0006235 dTTP biosynthetic process [PMID:19540237]" /note="Nucleoside monophosphate and nucleoside diphosphate kinase; functions in the de novo biosynthesis of pyrimidine deoxyribonucleotides; thymidylate/uridylate kinase that converts nucleoside monophosphates, dTMP and dUMP to nucleoside diphosphates, dTDP and dUDP; nucleoside diphosphate kinase that converts nucleoside diphosphates, dTDP and dUDP to dTTP and dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe tmp1; human homolog DTYMK can complement the cdc8 null mutant" /db_xref="GeneID:853520" /db_xref="SGD:S000003818" ORIGIN 1 mmgrgklili egldrtgktt qcnilykklq pnckllkfpe rstrigglin eyltddsfql 61 sdqaihllfs anrweivdki kkdllegkni vmdryvysgv aysaakgtng mdldwclqpd 121 vgllkpdltl flstqdvdnn aeksgfgder yetvkfqekv kqtfmklldk eirkgdesit 181 ivdvtnkgiq evealiwqiv epvlsthidh dkfsff // LOCUS NP_012592 147 aa linear PLN 30-JUN-2025 DEFINITION Aps2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012592 VERSION NP_012592.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181716.1 REFERENCE 1 (residues 1 to 147) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 147) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 147) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 147) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08845. Method: conceptual translation. FEATURES Location/Qualifiers source 1..147 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..147 /product="Aps2p" /calculated_mol_wt="17242" Region 3..146 /region_name="longin-like" /note="Longin-like domains; cl38905" /db_xref="CDD:365781" CDS 1..147 /gene="APS2" /locus_tag="YJR058C" /gene_synonym="YAP17" /coded_by="NM_001181716.1:1..444" /experiment="EXISTENCE:curator inference:GO:0006886 intracellular protein transport [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030122 AP-2 adaptor complex [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:8157009]" /experiment="EXISTENCE:physical interaction:GO:0030122 AP-2 adaptor complex [PMID:10564262]" /note="Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex" /db_xref="GeneID:853521" /db_xref="SGD:S000003819" ORIGIN 1 mavqfilcfn kqgvvrlvrw fdvhssdpqr sqdaiaqiyr lissrdhkhq snfvefsdst 61 kliyrryagl yfvmgvdlld depiylchih lfvevldaff gnvceldivf nfykvymimd 121 emfiggeiqe iskdmllerl sildrld // LOCUS NP_012593 818 aa linear PLN 30-JUN-2025 DEFINITION protein kinase PTK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012593 VERSION NP_012593.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181717.3 REFERENCE 1 (residues 1 to 818) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 818) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 818) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 818) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08846. On Jul 30, 2012 this sequence version replaced NP_012593.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..818 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..818 /product="protein kinase PTK2" /EC_number="2.7.11.1" /calculated_mol_wt="91270" Region 261..562 /region_name="STKc_HAL4_like" /note="Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; cd13994" /db_xref="CDD:270896" Site order(261..265,269,283,285,319,341..344,347,349,388,390, 392..393,395,406,409,432..435) /site_type="active" /db_xref="CDD:270896" Site order(261..265,269,283,285,319,341..344,347,388,390, 392..393,395,406) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270896" Site order(265,347,349,388,390,392,409,432..435) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270896" Site order(405..413,418..423,429..435) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270896" CDS 1..818 /gene="PTK2" /locus_tag="YJR059W" /gene_synonym="STK2" /coded_by="NM_001181717.3:1..2457" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894|PMID:16510118]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16510118]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12518319]" /experiment="EXISTENCE:mutant phenotype:GO:0000296 spermine transport [PMID:8920934]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:11003661]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0015847 putrescine transport [PMID:9154797]" /experiment="EXISTENCE:mutant phenotype:GO:0015848 spermidine transport [PMID:9154797]" /note="Serine/threonine protein kinase; involved in regulation of ion transport across plasma membrane; carboxyl terminus is essential for glucose-dependent Pma1p activation via phosphorylation of Pma1p-Ser899; enhances spermine uptake; PTK2 has a paralog, PTK1, that arose from the whole genome duplication" /db_xref="GeneID:853522" /db_xref="SGD:S000003820" ORIGIN 1 magngkdkev dkspsvstlk llgkrlfnss shtdnsslll saeqlgngrs lrkrptspsi 61 sgsgsggnsp sssagarqrs aslhrrknna svgfsngsvs shkssvalqd likhnnnpyl 121 nspsdilgtg tgiastrdrd ravldrekek erarnkernt hhaglpqrsn smashhfpne 181 nivynpygis pnharpdtaf adtlntnken dlsfymhdgn skirmlplpi anpndflped 241 mkqysvhltd nfvfdtdnkp igsggssevr kvkssyrqkd vyalkklnmi yhespekfyk 301 rcskefiiak hlshnvhitn tfyllkvptt tyttrgwgfi melgvkdlfq lmertgwknv 361 pfnekyclfk qvaqgikfch dngiahrdlk penvliskeg ickltdfgis dwyhviphdy 421 tspvktcqgm igsppytppe vmyfdakkhy pekfqkpynp lamdsyalgi mlitminnii 481 pfidscntda rfrefevsyd nfinhqnphf rdkgchkpgp gseyslarnf kntdatriaw 541 rladpnpatr ytmddlfndp ffqqietcve pndddlvrvp elrkststnd fsensldaph 601 dqevihtsnp flkketltsk prsmleiaes pslkqkskvk dsaktkthdv gdeggnestk 661 pkqqdkkenl kkdevkngdk dkvieeattt nvdsilekpt ptstkvednl seddstmkel 721 ksmlnstptt pthngptplp akagtqldkr msdlslkset pastknfsap nvssssnslr 781 slgspsvsss kkkkvihhhl ditnsvtnms svsafisr // LOCUS NP_012594 351 aa linear PLN 30-JUN-2025 DEFINITION Cbf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012594 VERSION NP_012594.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181718.1 REFERENCE 1 (residues 1 to 351) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 351) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 351) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 351) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08847. Method: conceptual translation. FEATURES Location/Qualifiers source 1..351 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..351 /product="Cbf1p" /calculated_mol_wt="39257" Region 217..303 /region_name="bHLHzip_scCBP1" /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; cd11398" /db_xref="CDD:381404" Site order(227..228,230..231,234..235,239,255..256) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:381404" Site order(237..238,241..242,244,248,256,260..261,264,266..268, 270..271,273..274) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:381404" CDS 1..351 /gene="CBF1" /locus_tag="YJR060W" /gene_synonym="CEP1; CPF1" /coded_by="NM_001181718.1:1..1056" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:9407032]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8665859|PMID:7891681|PMID:9894911]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:15302821]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:7891681]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:15111622]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:11222754|PMID:9407032|PMID:2249662|PMID:2057354]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12820973]" /experiment="EXISTENCE:direct assay:GO:0089713 Cbf1-Met4-Met28 complex [PMID:8665859|PMID:9171357]" /experiment="EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:9584087]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10921921|PMID:15302821|PMID:22696683]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:21131275|PMID:7891681|PMID:2249662]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:7891681]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:2185892|PMID:2057354|PMID:2188087]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17351075|PMID:7891681|PMID:22696683|PMID:20935143|PM ID:7601277]" /experiment="EXISTENCE:mutant phenotype:GO:0061431 cellular response to methionine [PMID:7891681]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20935143]" /experiment="EXISTENCE:mutant phenotype:GO:1900059 positive regulation of sulfate assimilation [PMID:7601277|PMID:7891681]" /experiment="EXISTENCE:mutant phenotype:GO:1900060 negative regulation of ceramide biosynthetic process [PMID:15302821]" /experiment="EXISTENCE:mutant phenotype:GO:1900090 positive regulation of inositol biosynthetic process [PMID:17351075|PMID:20935143]" /experiment="EXISTENCE:physical interaction:GO:0000776 kinetochore [PMID:11070082]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:8665859]" /note="Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853523" /db_xref="SGD:S000003821" ORIGIN 1 mnslannnkl stedeeihsa rkrgyneeqn ysearkkqrd qgllsqesnd gnidsallse 61 gatlkgtqsq yesgltsnkd ekgsddedas vaeaavaatv nytdliqgqe dssdahtsnq 121 tnangehkds lngeraitps negvkpntsl egmtsspmes tqqskndmli plaehdrgpe 181 hqqddedndd adidlkkdis mqpgrrgrkp ttlattdewk kqrkdshkev errrrenint 241 ainvlsdllp vresskaail acaaeyiqkl ketdeaniek wtlqkllseq nasqlasane 301 klqeelgnay keieymkrvl rkegieyedm hthkkqener kstrsdnphe a // LOCUS NP_012595 935 aa linear PLN 30-JUN-2025 DEFINITION Mnn14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012595 VERSION NP_012595.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181719.1 REFERENCE 1 (residues 1 to 935) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 935) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 935) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 935) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 935) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 935) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 935) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08848. Method: conceptual translation. FEATURES Location/Qualifiers source 1..935 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..935 /product="Mnn14p" /calculated_mol_wt="108297" Region 470..720 /region_name="LicD" /note="LicD family; pfam04991" /db_xref="CDD:428243" CDS 1..935 /gene="MNN14" /locus_tag="YJR061W" /coded_by="NM_001181719.1:1..2808" /experiment="EXISTENCE:genetic interaction:GO:0006491 N-glycan processing [PMID:28101612]" /note="Protein required for N-glycan mannosylphosphorylation; non-essential gene; transcription repressed by Rm101p; MNN14 has a paralog, MNN4, that arose from the whole genome duplication" /db_xref="GeneID:853524" /db_xref="SGD:S000003822" ORIGIN 1 mmlslrrfsm yvlrslrlhf kkiiitllti qllfitifvl ggrssiidgn wksfmalffk 61 playtnrnnn hasfdlrskd nvaklyekmn fdtsgkwidt ytlknnlltv kmgpekgqvl 121 dsvdelryyd ndprlvwsvl ldhllesdsn eyafswydwa nfdstnklia lrhtniscqf 181 vcegafdknv lemvesevqe plfvtnrnky deslwynrvr kvvdsnsvqq aihdhcmnnd 241 aysngtpfel pfiiseiser lrpevydlqa knhllysnft plsltvldsd kdayrinlkt 301 tdssksnivq tnllqnyikr hrnemvngdl ifnhtsmfek flhhgstkkr kldvealdkt 361 iyageylels psdfqfnake riieletrlr seglpshdth ylrslktsvn tspalqqkyf 421 aeasditdat adghhrdrrf fsighnllnd pqefearlns lirnfqkfvk angliswlsh 481 gtlygylydg lkfpwdvdhd lqmpikhlhy lsqyfnqsli ledpregngr flldvgsait 541 vgvhgngenn idarfidids giyiditgls vssdaakqym skfveeessg esfsaliedy 601 kfdendyfde vdgreglaky tihelmewvn shpddftdae knlvtktykk elaisrsdya 661 ekdlspkqry lvnekynlyn crnqhfssln iisplrntmf sgvsafvpnr piatlnneyk 721 vpakygllsf qgkvylpefr ywfsfadmkk fanlqlkepk itrlesplnd lkfsdislli 781 tnilkcgfhs vfaslfnsfd stvyrlkele iqydpslsee ekssllktlr rgmskkiksp 841 ekdpiiyiye rklwenvekl lnasniynia sqvekekgke fversqqvye rnfdgfrlpd 901 ggnsktvndl nskglnlfgd nkktsnnifg sdqky // LOCUS NP_012596 457 aa linear PLN 30-JUN-2025 DEFINITION amidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012596 VERSION NP_012596.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181720.3 REFERENCE 1 (residues 1 to 457) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 457) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 457) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 457) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08849. On Jul 30, 2012 this sequence version replaced NP_012596.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..457 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..457 /product="amidase" /calculated_mol_wt="51766" Region 20..315 /region_name="ScNTA1_like" /note="Saccharomyces cerevisiae N-terminal amidase NTA1, and related proteins (class 3 nitrilases); cd07566" /db_xref="CDD:143590" Site order(63,136,140,143,187..188,190..191,217) /site_type="active" /note="putative active site [active]" /db_xref="CDD:143590" Site order(63,136,187) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:143590" Site order(137..140,142,149..151,188,190..194,197..198,228..229, 231..233,235..236,260..261,309..313) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:143590" CDS 1..457 /gene="NTA1" /locus_tag="YJR062C" /gene_synonym="DEA1" /coded_by="NM_001181720.3:1..1374" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008418 protein-N-terminal asparagine amidohydrolase activity [PMID:7744855|PMID:23218487]" /experiment="EXISTENCE:direct assay:GO:0070773 protein-N-terminal glutamine amidohydrolase activity [PMID:23218487]" /experiment="EXISTENCE:mutant phenotype:GO:0008418 protein-N-terminal asparagine amidohydrolase activity [PMID:7744855]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:7744855]" /experiment="EXISTENCE:mutant phenotype:GO:0031365 N-terminal protein amino acid modification [PMID:7744855]" /experiment="EXISTENCE:mutant phenotype:GO:0070773 protein-N-terminal glutamine amidohydrolase activity [PMID:7744855]" /note="Amidase; removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation" /db_xref="GeneID:853525" /db_xref="SGD:S000003823" ORIGIN 1 mlidaihgak mstkllvslk vlviqlnpqi gqvdqtikrt wsildkvtks atyvkpdiil 61 fpefaltgys fharkdilpy vtkkdegpsf elaksisekf qcytiigype dddeqklyns 121 alvvnpqgeq ifnyrktfly dtemnwdcee npegfqtfpm dfskcaklsn edsynrdvtl 181 kasigicmdl spykfmapfn hfefssfcvd nnvelilcpm awlnstsitd kqtlhnnsll 241 eaaknkiafa lkeqglplag sqgiyqlkig dsqrtprvps ddstseykdm depdmsnvny 301 wilrffpfly fksrinwfkn ssliesilgk trmpldheyy kdgkhkedti dlldseevik 361 dtvlektflg tslgqpwkfq gknailvlan rcgtedgtti fagssgiykf ngkkpkgsqd 421 ddessldsln esvellgnlg kglegailre vqfevfr // LOCUS NP_012597 125 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase I core subunit RPA12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012597 VERSION NP_012597.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181721.1 REFERENCE 1 (residues 1 to 125) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 125) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 125) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 125) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08850. Method: conceptual translation. FEATURES Location/Qualifiers source 1..125 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..125 /product="DNA-directed RNA polymerase I core subunit RPA12" /calculated_mol_wt="13529" Region 9..122 /region_name="RPB9" /note="DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]; COG1594" /db_xref="CDD:441202" Region 78..124 /region_name="Zn-ribbon_RPA12" /note="C-terminal zinc ribbon domain of RPA12 subunit of RNA polymerase I; cd10507" /db_xref="CDD:259792" Site order(86,89,114,117) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:259792" CDS 1..125 /gene="RPA12" /locus_tag="YJR063W" /gene_synonym="RRN4" /coded_by="NM_001181721.1:1..378" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969|PMID:8417319]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:9121426|PMID:1871118]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27637775]" /experiment="EXISTENCE:mutant phenotype:GO:0006363 termination of RNA polymerase I transcription [PMID:18413718|PMID:15073335]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:27637775]" /note="RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex; physically interacts with transcriptional activator Msn4p, to regulate transcription of AYR1, a gene involved in lipid metabolism" /db_xref="GeneID:853526" /db_xref="SGD:S000003824" ORIGIN 1 msvvgslifc ldcgdllenp navlgsnvec sqckaiypks qfsnlkvvtt taddafpssl 61 rakksvvkts lkknelkdga tikekcpqcg neemnyhtlq lrsadegatv fytctscgyk 121 frtnn // LOCUS NP_012598 562 aa linear PLN 30-JUN-2025 DEFINITION chaperonin-containing T-complex subunit CCT5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012598 VERSION NP_012598.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181722.1 REFERENCE 1 (residues 1 to 562) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 562) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 562) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 562) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08851. Method: conceptual translation. FEATURES Location/Qualifiers source 1..562 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..562 /product="chaperonin-containing T-complex subunit CCT5" /calculated_mol_wt="61783" Region 23..555 /region_name="TCP1_epsilon" /note="TCP-1 (CTT or eukaryotic type II) chaperonin family, epsilon subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins...; cd03339" /db_xref="CDD:239455" Site order(38,42,70..73,75,93,95,99,103,106,413,550..555) /site_type="other" /note="ring oligomerisation interface [polypeptide binding]" /db_xref="CDD:239455" Site order(65..67,117,121,186,425,443,483,527,529) /site_type="other" /note="ATP/Mg binding site [chemical binding]" /db_xref="CDD:239455" Site order(463,481,490,492..493,496) /site_type="active" /note="stacking interactions [active]" /db_xref="CDD:239455" CDS 1..562 /gene="CCT5" /locus_tag="YJR064W" /gene_synonym="TCP5" /coded_by="NM_001181722.1:1..1689" /experiment="EXISTENCE:direct assay:GO:0005832 chaperonin-containing T-complex [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:16762366]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16762366]" /experiment="EXISTENCE:physical interaction:GO:0005832 chaperonin-containing T-complex [PMID:15704212]" /note="Subunit of the cytosolic chaperonin Cct ring complex; related to Tcp1p, required for the assembly of actin and tubulins in vivo" /db_xref="GeneID:853527" /db_xref="SGD:S000003825" ORIGIN 1 maarpqqppm empdlsnaiv aqdemgrpfi ivkdqgnkkr qhgleakksh ilaarsvasi 61 iktslgprgl dkilispdge ititndgati lsqmeldnei akllvqlsks qddeigdgtt 121 gvvvlasall dqaleliqkg ihpikiangf deaaklaisk leetcddisa sndelfrdfl 181 lraaktslgs kivskdhdrf aemaveavin vmdkdrkdvd fdlikmqgrv ggsisdskli 241 ngvildkdfs hpqmpkcvlp kegsdgvkla iltcpfeppk pktkhkldis sveeyqklqt 301 yeqdkfkemi ddvkkagadv vicqwgfdde anhlllqndl pavrwvggqe lehiaistng 361 rivprfqdls kdklgtcsri yeqefgttkd rmliieqske tktvtcfvrg snkmivdeae 421 ralhdslcvv rnlvkdsrvv ygggaaevtm slavseeadk qrgidqyafr gfaqaldtip 481 mtlaensgld pigtlstlks kqlkekisni gvdclgygsn dmkelfvvdp figkkqqill 541 atqlcrmilk idnviisgkd ey // LOCUS NP_012599 449 aa linear PLN 30-JUN-2025 DEFINITION actin-related protein 3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012599 VERSION NP_012599.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181723.3 REFERENCE 1 (residues 1 to 449) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 449) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 449) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 449) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08852. On Jul 30, 2012 this sequence version replaced NP_012599.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..449 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..449 /product="actin-related protein 3" /calculated_mol_wt="49411" Region 8..441 /region_name="ASKHA_NBD_Arp3-like" /note="nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; cd10221" /db_xref="CDD:466822" CDS 1..449 /gene="ARP3" /locus_tag="YJR065C" /gene_synonym="ACT4" /coded_by="NM_001181723.3:1..1350" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:15657399]" /experiment="EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:10377407]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:9210376]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:15657399]" /experiment="EXISTENCE:mutant phenotype:GO:0034314 Arp2/3 complex-mediated actin nucleation [PMID:16862144]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:15534003|PMID:10377407]" /note="Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity" /db_xref="GeneID:853528" /db_xref="SGD:S000003826" ORIGIN 1 msylnnpavv mdngtgltkl gfagndspsw vfptaiataa psntkkssgv gapsavsnea 61 syfgnstsat nfngatggll snnlsgkrgt edldfyigne alvasqgpsy slsypirhgq 121 venwdhmerf wensifkylr tepedhffll tepplnppen reqvaeiffe sfncaglyia 181 vqavlalaas wtsskvtdrs ltgtvidsgd gvthvipvae gyvigsaikn ipiagrditl 241 fiqsllrerg eadtslrtae kikqeycyvc pdivkefnkf dkdpskfaqf vvenqektrr 301 kvvdigyerf lapeiffnpe iassdfltpl ptvvdqtiqa cpidvrkgly nnivlsggst 361 mfkdfgrrlq rdlksivnnr iaqsellsgt kstgvdvsvi shrkqrnavw fggsllaqta 421 efkgychtkk dyeeygpeiv rnfslfnmv // LOCUS NP_012600 2470 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol kinase-related protein kinase TOR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012600 VERSION NP_012600.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181724.1 REFERENCE 1 (residues 1 to 2470) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2470) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2470) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 2470) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08853. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2470 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..2470 /product="phosphatidylinositol kinase-related protein kinase TOR1" /EC_number="2.7.11.1" /calculated_mol_wt="281010" Region 229..279 /region_name="HEAT_EZ" /note="HEAT-like repeat; pfam13513" /db_xref="CDD:463906" Region 279..2470 /region_name="TEL1" /note="Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032" /db_xref="CDD:227365" Region 588..620 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(602..603,606,619..620,650..651,654..655,658,686..687, 690,693..694,697,728..729,732,735..736,769..770,773, 776..777) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 632..658 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 668..698 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 706..736 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 749..778 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 792..827 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..2470 /gene="TOR1" /locus_tag="YJR066W" /gene_synonym="DRR1" /coded_by="NM_001181724.1:1..7413" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12719473]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:18723607|PMID:25046117|PMID:19748353|PMID:12719473|P MID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:38127619|PMID:26582391]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16900101]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18723607|PMID:16900101]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10973982]" /experiment="EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:12719473]" /experiment="EXISTENCE:direct assay:GO:0018105 peptidyl-serine phosphorylation [PMID:26582391]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:9461583]" /experiment="EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:9461583]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:27922823]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:27922823]" /experiment="EXISTENCE:genetic interaction:GO:1905356 regulation of snRNA pseudouridine synthesis [PMID:27268497]" /experiment="EXISTENCE:mutant phenotype:GO:0004672 protein kinase activity [PMID:10329624]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:8741837]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:17698581]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:14736892]" /experiment="EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:8186460|PMID:12719473]" /experiment="EXISTENCE:mutant phenotype:GO:0031930 mitochondria-nucleus signaling pathway [PMID:11997479]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:31144305]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:10198052]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:16900101]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:9096347]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:8741837]" /experiment="EXISTENCE:mutant phenotype:GO:0090153 regulation of sphingolipid biosynthetic process [PMID:23363605]" /experiment="EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:12408816]" /note="PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; indole-3-acetic acid, an ATP-competitive TORC1 inhibitor, accumulates upon entry into stationary phase; malonyl-CoA is a direct ATP-competitive inhibitor of TORC1; TOR1 has a paralog, TOR2, that arose from the whole genome duplication" /db_xref="GeneID:853529" /db_xref="SGD:S000003827" ORIGIN 1 mepheeqiwk skllkaannd mdmdrnvpla pnlnvnmnmk mnasrngdef gltssrfdgv 61 vigsngdvnf kpilekifre ltsdykeerk lasislfdll vslehelsie efqavsndin 121 nkilelvhtk ktstrvgavl sidtlisfya yterlpnets rlagylrgli psndvevmrl 181 aaktlgklav pggtytsdfv efeiksclew ltasteknsf ssskpdhakh aalliitala 241 encpyllyqy lnsildniwr alrdphlvir idasitlakc lstlrnrdpq ltsqwvqrla 301 tsceygfqvn tlecihasll vykeilflkd pflnqvfdqm clnciayenh kakmirekiy 361 qivpllasfn pqlfagkylh qimdnyleil tnapankiph lkddkpqili sigdiayevg 421 pdiapyvkqi ldyiehdlqt kfkfrkkfen eifycigrla vplgpvlgkl lnrnildlmf 481 kcplsdymqe tfqilterip slgpkindel lnlvcstlsg tpfiqpgspm eipsfsrera 541 rewrnknilq ktgesnddnn dikiiiqafr mlkniksrfs lvefvrival syiehtdprv 601 rklaaltsce iyvkdnickq tslhslntvs evlskllait iadplqdirl evlknlnpcf 661 dpqlaqpdnl rllftalhde sfniqsvame lvgrlssvnp ayvipsirki llelltklkf 721 stssrekeet asllctlirs skdvakpyie pllnvllpkf qdtsstvast alrtigelsv 781 vggedmkiyl kdlfpliikt fqdqsnsfkr eaalkalgql aassgyvidp lldypellgi 841 lvnilktens qnirrqtvtl igilgaidpy rqkerevtst tdisteqnap pidiallmqg 901 mspsndeyyt tvvihcllki lkdpslssyh taviqaimhi fqtlglkcvs fldqiiptil 961 dvmrtcsqsl lefyfqqlcs liiivrqhir phvdsifqai kdfssvaklq itlvsvieai 1021 skalegefkr lvpltltlfl vilendkssd kvlsrrvlrl lesfgpnleg yshlitpkiv 1081 qmaeftsgnl qrsaiitigk lakdvdlfem ssrivhsllr vlssttsdel skvimntlsl 1141 lliqmgtsfa ifipvinevl mkkhiqhtiy ddltnrilnn dvlptkilea nttdykpaeq 1201 meaadagvak lpinqsvlks awnssqqrtk edwqewskrl siqllkesps halracsnla 1261 smyyplakel fntafacvwt elysqyqedl igslcialss plnppeihqt llnlvefmeh 1321 ddkalpiptq slgeyaerch ayakalhyke ikfikepens tieslisinn qlnqtdaaig 1381 ilkhaqqhhs lqlketwfek lerwedalha ynerekagdt svsvtlgkmr slhalgeweq 1441 lsqlaarkwk vsklqtkkli aplaagaawg lgewdmleqy isvmkpkspd keffdailyl 1501 hkndydnask hilnardllv teisalines ynraysvivr tqiitefeei ikykqlppns 1561 ekklhyqnlw tkrllgcqkn vdlwqrvlrv rslvikpkqd lqiwikfanl crksgrmrla 1621 nkalnmlleg gndpslpntf kapppvvyaq lkyiwatgay kealnhligf tsrlahdlgl 1681 dpnnmiaqsv klssastapy veeytkllar cflkqgewri atqpnwrntn pdailgsyll 1741 athfdknwyk awhnwalanf evismvqeet klnggknddd ddtavnndnv ridgsilgsg 1801 sltingnryp leliqrhvvp aikgffhsis lletsclqdt lrlltllfnf ggikevsqam 1861 yegfnlmkie nwlevlpqli srihqpdptv snsllsllsd lgkahpqalv ypltvaikse 1921 svsrqkaals iiekirihsp vlvnqaelvs helirvavlw helwyegled asrqffvehn 1981 iekmfstlep lhkhlgnepq tlsevsfqks fgrdlndaye wlnnykkskd innlnqawdi 2041 yynvfrkitr qipqlqtldl qhvspqllat hdlelavpgt yfpgkptiri akfeplfsvi 2101 sskqrprkfs ikgsdgkdyk yvlkghedir qdslvmqlfg lvntllknds ecfkrhldiq 2161 qypaiplspk sgllgwvpns dtfhvlireh rdakkiplni ehwvmlqmap dyenltllqk 2221 ievftyaldn tkgqdlykil wlksrssetw lerrttytrs lavmsmtgyi lglgdrhpsn 2281 lmldritgkv ihidfgdcfe aailrekype kvpfrltrml tyamevsgie gsfritcenv 2341 mrvlrdnkes lmaileafal dplihwgfdl ppqklteqtg iplplinpse llrkgaitve 2401 eaanmeaeqq netknaraml vlrritdklt gndikrfnel dvpeqvdkli qqatsierlc 2461 qhyigwcpfw // LOCUS NP_012601 141 aa linear PLN 30-JUN-2025 DEFINITION Yae1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012601 VERSION NP_012601.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181725.1 REFERENCE 1 (residues 1 to 141) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 141) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 141) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 141) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08854. Method: conceptual translation. FEATURES Location/Qualifiers source 1..141 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..141 /product="Yae1p" /calculated_mol_wt="15945" Region 34..72 /region_name="Yae1_N" /note="Essential protein Yae1, N terminal; pfam09811" /db_xref="CDD:430844" CDS 1..141 /gene="YAE1" /locus_tag="YJR067C" /coded_by="NM_001181725.1:1..426" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:26182403]" /experiment="EXISTENCE:direct assay:GO:0062092 Yae1-Lto1 complex [PMID:26182403]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:26182403]" /note="Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human YAE1D1, which is overexpressed in oral cancers; co-expression of YAE1D1 and LTO1 homolog ORAOV1 restores growth and Rli1p maturation after YAE1 depletion" /db_xref="GeneID:853530" /db_xref="SGD:S000003828" ORIGIN 1 msntwddvwa sdsdveters pdlvklrenh skrgyldgiv sskeeklqeg fndgfptgak 61 lgkqvgiimg illglrtrfg dededlskay idaqkelrin kvlsksifdp nfdlqekhpl 121 itkwtdiant ycekyhvpsi q // LOCUS NP_012602 353 aa linear PLN 30-JUN-2025 DEFINITION replication factor C subunit 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012602 VERSION NP_012602.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181726.3 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 353) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08855. On Jul 30, 2012 this sequence version replaced NP_012602.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..353 /product="replication factor C subunit 2" /calculated_mol_wt="39611" Region 23..353 /region_name="rfc" /note="replication factor C small subunit; Reviewed; PRK00440" /db_xref="CDD:234763" CDS 1..353 /gene="RFC2" /locus_tag="YJR068W" /coded_by="NM_001181726.3:1..1062" /experiment="EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:8995429|PMID:12604797]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23613772]" /experiment="EXISTENCE:direct assay:GO:0005663 DNA replication factor C complex [PMID:8202350]" /experiment="EXISTENCE:direct assay:GO:0006272 leading strand elongation [PMID:1346062]" /experiment="EXISTENCE:direct assay:GO:0031389 Rad17 RFC-like complex [PMID:12604797|PMID:10660302]" /experiment="EXISTENCE:mutant phenotype:GO:0000076 DNA replication checkpoint signaling [PMID:9671499]" /experiment="EXISTENCE:physical interaction:GO:0007062 sister chromatid cohesion [PMID:11389843]" /experiment="EXISTENCE:physical interaction:GO:0031389 Rad17 RFC-like complex [PMID:10660302]" /experiment="EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]" /experiment="EXISTENCE:physical interaction:GO:0031391 Elg1 RFC-like complex [PMID:12912927]" /note="Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon" /db_xref="GeneID:853531" /db_xref="SGD:S000003829" ORIGIN 1 mfegfgpnkk rkisklaaeq slaqqpwvek yrpknldevt aqdhavtvlk ktlksanlph 61 mlfygppgtg ktstilaltk elygpdlmks rilelnasde rgisivrekv knfarltvsk 121 pskhdlenyp cppykiiild eadsmtadaq salrrtmety sgvtrfclic nyvtriidpl 181 asrcskfrfk aldasnaidr lrfiseqenv kcddgvleri ldisagdlrr gitllqsask 241 gaqylgdgkn itstqveela gvvphdilie ivekvksgdf deikkyvntf mksgwsaasv 301 vnqlheyyit ndnfdtnfkn qiswllfttd srlnngtneh iqllnllvki sql // LOCUS NP_012603 197 aa linear PLN 30-JUN-2025 DEFINITION nucleoside triphosphate pyrophosphohydrolase HAM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012603 VERSION NP_012603.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181727.1 REFERENCE 1 (residues 1 to 197) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 197) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 197) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08856. Method: conceptual translation. FEATURES Location/Qualifiers source 1..197 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..197 /product="nucleoside triphosphate pyrophosphohydrolase HAM1" /EC_number="3.6.1.9" /calculated_mol_wt="21962" Region 5..193 /region_name="TIGR00042" /note="non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family" /db_xref="CDD:272870" Site order(12,14..15,18,77..79,92..93,118,151,153..154,180..181) /site_type="active" /db_xref="CDD:238285" Site order(45..47,84..85,88,91,94) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:238285" CDS 1..197 /gene="HAM1" /locus_tag="YJR069C" /coded_by="NM_001181727.1:1..594" /experiment="EXISTENCE:direct assay:GO:0004170 dUTP diphosphatase activity [PMID:17899088]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008828 dATP diphosphatase activity [PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0009213 pyrimidine deoxyribonucleoside triphosphate catabolic process [PMID:22531138|PMID:17899088]" /experiment="EXISTENCE:direct assay:GO:0009217 purine deoxyribonucleoside triphosphate catabolic process [PMID:17090528|PMID:17899088|PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0035870 dITP diphosphatase activity [PMID:17090528|PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0036217 dGTP diphosphatase activity [PMID:22531138|PMID:17090528]" /experiment="EXISTENCE:direct assay:GO:0036218 dTTP diphosphatase activity [PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0036219 GTP diphosphatase activity [PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0036220 ITP diphosphatase activity [PMID:22531138|PMID:17899088]" /experiment="EXISTENCE:direct assay:GO:0036221 UTP diphosphatase activity [PMID:17899088]" /experiment="EXISTENCE:direct assay:GO:0036222 XTP diphosphatase activity [PMID:22531138]" /experiment="EXISTENCE:direct assay:GO:0047840 dCTP diphosphatase activity [PMID:22531138]" /experiment="EXISTENCE:mutant phenotype:GO:0009213 pyrimidine deoxyribonucleoside triphosphate catabolic process [PMID:17899088]" /experiment="EXISTENCE:mutant phenotype:GO:0009217 purine deoxyribonucleoside triphosphate catabolic process [PMID:22308425]" /note="Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA" /db_xref="GeneID:853532" /db_xref="SGD:S000003830" ORIGIN 1 msnneivfvt gnanklkevq siltqevdnn nktihlinea ldleelqdtd lnaialakgk 61 qavaalgkgk pvfvedtalr fdefnglpga yikwflksmg lekivkmlep fenknaeavt 121 ticfadsrge yhffqgitrg kivpsrgptt fgwdsifepf dshgltyaem skdaknaish 181 rgkafaqfke ylyqndf // LOCUS NP_012604 325 aa linear PLN 30-JUN-2025 DEFINITION deoxyhypusine monooxygenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012604 VERSION NP_012604.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181728.1 REFERENCE 1 (residues 1 to 325) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 325) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 325) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 325) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08857. Method: conceptual translation. FEATURES Location/Qualifiers source 1..325 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..325 /product="deoxyhypusine monooxygenase" /EC_number="1.14.99.29" /calculated_mol_wt="36034" Region 62..150 /region_name="HEAT_2" /note="HEAT repeats; pfam13646" /db_xref="CDD:433376" Region 182..307 /region_name="HEAT" /note="HEAT repeat [General function prediction only]; COG1413" /db_xref="CDD:441023" Region 187..241 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 250..281 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 283..309 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..325 /gene="LIA1" /locus_tag="YJR070C" /gene_synonym="MMD1" /coded_by="NM_001181728.1:1..978" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008612 peptidyl-lysine modification to peptidyl-hypusine [PMID:16371467]" /experiment="EXISTENCE:direct assay:GO:0019135 deoxyhypusine monooxygenase activity [PMID:16371467]" /experiment="EXISTENCE:mutant phenotype:GO:0000226 microtubule cytoskeleton organization [PMID:14767070]" /experiment="EXISTENCE:mutant phenotype:GO:0008612 peptidyl-lysine modification to peptidyl-hypusine [PMID:16371467]" /experiment="EXISTENCE:mutant phenotype:GO:0019135 deoxyhypusine monooxygenase activity [PMID:16371467]" /note="Deoxyhypusine hydroxylase; HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853534" /db_xref="SGD:S000003831" ORIGIN 1 mstnfekhfq envdectleq lrdilvnksg ktvlanrfra lfnlktvaee fatkpeeakk 61 aieyiaesfv ndksellkhe vayvlgqtkn ldaaptlrhv mldqnqepmv rheaaealga 121 lgdkdslddl nkaakedphv avretcelai nrinwthgga kdkenlqqsl yssidpappl 181 plekdatipe lqallndpkq plfqryramf rlrdigtdea ilalatgfsa esslfkheia 241 yvfgqigspa avpslievlg rkeeapmvrh eaaealgaia spevvdvlks ylndevdvvr 301 escivaldmy dyensneley aptan // LOCUS NP_012606 385 aa linear PLN 30-JUN-2025 DEFINITION GTPase NPA3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012606 VERSION NP_012606.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181730.3 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 385) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08858. On Jul 30, 2012 this sequence version replaced NP_012606.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..385 /product="GTPase NPA3" /calculated_mol_wt="43064" Region 5..254 /region_name="GPN1" /note="GPN-loop GTPase 1; cd17870" /db_xref="CDD:349779" Site order(11..18,173..174,176..177,238..240) /site_type="active" /db_xref="CDD:349779" CDS 1..385 /gene="NPA3" /locus_tag="YJR072C" /gene_synonym="EPA1; GPN1" /coded_by="NM_001181730.3:1..1158" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:21844196]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006913 nucleocytoplasmic transport [PMID:21844196]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:15082539]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:21844196]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:21532343]" /note="Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853535" /db_xref="SGD:S000003833" ORIGIN 1 mslstiicig magsgkttfm qrlnshlrae ktppyvinld pavlrvpyga nidirdsiky 61 kkvmenyqlg pngaivtsln lfstkidqvi rlveqkkdkf qnciidtpgq iecfvwsasg 121 aiitesfass fptviayivd tprnsspttf msnmlyacsi lyktklpmiv vfnktdvcka 181 dfakewmtdf esfqaaiked qdlngdnglg sgymsslvns mslmleefys qldvvgvssf 241 tgdgfdefmq cvdkkvdeyd qyykqereka lnlkkkkeem rkqkslnglm kdlglnekss 301 aaasdndsid aisdleedan dglvdrdede gvereytfpg eertkgevne nsapdlqrry 361 qeamqqvgkt assetaenia kyirn // LOCUS NP_012607 206 aa linear PLN 30-JUN-2025 DEFINITION bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012607 VERSION NP_012607.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181731.1 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 206) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08859. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..206 /product="bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase" /EC_number="2.1.1.17" /EC_number="2.1.1.71" /calculated_mol_wt="23019" Region 100..199 /region_name="PEMT" /note="Phospholipid methyltransferase; pfam04191" /db_xref="CDD:461218" CDS 1..206 /gene="OPI3" /locus_tag="YJR073C" /gene_synonym="PEM2" /coded_by="NM_001181731.1:1..621" /experiment="EXISTENCE:direct assay:GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity [PMID:2445736]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:2445736]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity [PMID:2445736]" /experiment="EXISTENCE:genetic interaction:GO:0006656 phosphatidylcholine biosynthetic process [PMID:2445736]" /experiment="EXISTENCE:mutant phenotype:GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity [PMID:2684666]" /experiment="EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:23000174|PMID:6337128]" /note="Methylene-fatty-acyl-phospholipid synthase; catalyzes the last two steps in phosphatidylcholine biosynthesis; also known as phospholipid methyltransferase" /db_xref="GeneID:853536" /db_xref="SGD:S000003834" ORIGIN 1 mkesvqeiiq qlihsvdlqs skfqlaivct mfnpifwniv armeyhkhsl tkmcggarkg 61 cymlaatifs lgivrdmvye salreqptcs litgenwtkl gvalfglgqv lvlssmyklg 121 itgtylgdyf gilmdervtg fpfnvsnnpm yqgstlsflg ialykgkpag lvvsavvyfm 181 ykialrweep ftamiyanrd kakknm // LOCUS NP_012608 218 aa linear PLN 30-JUN-2025 DEFINITION Ran GTPase-binding protein MOG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012608 VERSION NP_012608.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181732.1 REFERENCE 1 (residues 1 to 218) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 218) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 218) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 218) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08860. Method: conceptual translation. FEATURES Location/Qualifiers source 1..218 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..218 /product="Ran GTPase-binding protein MOG1" /calculated_mol_wt="24176" Region 36..218 /region_name="Mog1" /note="homolog to Ran-Binding Protein Mog1p; binds to the small GTPase Ran, which plays an important role in nuclear import. Binding is independent of Ran's nucleotide state (RanGTP/RanGDP); cd00224" /db_xref="CDD:238137" Site order(38,41..42,57..58,64..65) /site_type="other" /note="putative Ran binding site [polypeptide binding]" /db_xref="CDD:238137" CDS 1..218 /gene="MOG1" /locus_tag="YJR074W" /coded_by="NM_001181732.1:1..657" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9860978]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:9860978|PMID:11509570]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:9860978|PMID:11024003]" /note="Conserved nuclear protein that interacts with GTP-Gsp1p; stimulates nucleotide release from Gsp1p; involved in nuclear protein import; nucleotide release is inhibited by Yrb1p" /db_xref="GeneID:853537" /db_xref="SGD:S000003835" ORIGIN 1 mkiekashis qpvqlstctl idtypghqgs mnnkevelyg gaittvvppg fidastlrev 61 pdtqevyvns rrdeeefedg latnesiivd lletvdksdl keawqfhved ltelngttkw 121 ealqedtvqq gtkftglvme vankwgkpdl aqtvvigval irltqfdtdv visinvpltk 181 eeasqasnke lparchavyq llqemvrkfh vvdtslfa // LOCUS NP_012609 396 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012609 VERSION NP_012609.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181733.3 REFERENCE 1 (residues 1 to 396) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 396) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 396) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 396) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08861. On Jul 30, 2012 this sequence version replaced NP_012609.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..396 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..396 /product="alpha-1,6-mannosyltransferase" /calculated_mol_wt="46166" Region 12..>119 /region_name="EnvC" /note="Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]; COG4942" /db_xref="CDD:443969" Region 144..235 /region_name="Gly_transf_sug" /note="Glycosyltransferase sugar-binding region containing DXD motif; pfam04488" /db_xref="CDD:398274" CDS 1..396 /gene="HOC1" /locus_tag="YJR075W" /coded_by="NM_001181733.3:1..1191" /experiment="EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:10037752]" /experiment="EXISTENCE:direct assay:GO:0000136 mannan polymerase complex [PMID:10037752]" /experiment="EXISTENCE:physical interaction:GO:0000136 mannan polymerase complex [PMID:9430634]" /note="Alpha-1,6-mannosyltransferase; involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele" /db_xref="GeneID:853538" /db_xref="SGD:S000003836" ORIGIN 1 makttkrass frrlmifaii alislafgvr ylfhnsnatd lqkilqnlpk eisqsinsan 61 niqssdsdlv qhfeslaqei rhqqevqakq fdkqrkilek kiqdlkqtpp eatlreriam 121 tfpydshvkf pafiwqtwsn degpervqdi kgmwesknpg fahevlnhdv inalvhhyfy 181 sipeiletye alpsiilkid ffkylillvh ggvyadidtf pvqpipnwip eelspsdigl 241 ivgveedaqr adwrtkyirr lqfgtwiiqa kpghpvlrei isriiettlq rkrddqlnvn 301 lrndlnimsw tgsglwtdti ftyfndfmrs gvrekvtwkl fhnlnqpkll sdvlvfpkfs 361 fncpnqidnd dphkkfyfit hlasqfwknt pkveqk // LOCUS NP_012610 415 aa linear PLN 30-JUN-2025 DEFINITION septin CDC11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012610 VERSION NP_012610.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181734.1 REFERENCE 1 (residues 1 to 415) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 415) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 415) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 415) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08862. Method: conceptual translation. FEATURES Location/Qualifiers source 1..415 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..415 /product="septin CDC11" /calculated_mol_wt="47518" Region 5..413 /region_name="CDC3" /note="Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5019" /db_xref="CDD:227352" CDS 1..415 /gene="CDC11" /locus_tag="YJR076C" /gene_synonym="PSL9" /coded_by="NM_001181734.1:1..1248" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:1934633]" /experiment="EXISTENCE:direct assay:GO:0001400 mating projection base [PMID:8791410]" /experiment="EXISTENCE:direct assay:GO:0001934 positive regulation of protein phosphorylation [PMID:14527412]" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:22144691|PMID:18550837|PMID:29321251]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:8636217]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18826657|PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:18826657]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:18826657]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0031105 septin complex [PMID:18550837]" /experiment="EXISTENCE:direct assay:GO:0032160 septin filament array [PMID:15282341]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0072687 meiotic spindle [PMID:18826657]" /experiment="EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:25971666]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:4950437]" /experiment="EXISTENCE:mutant phenotype:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:physical interaction:GO:0031105 septin complex [PMID:9813094]" /note="Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells" /db_xref="GeneID:853539" /db_xref="SGD:S000003837" ORIGIN 1 msgiidassa lrkrkhlkrg itftvmivgq sgsgrstfin tlcgqqvvdt sttillptdt 61 steidlqlre etveleddeg vkiqlniidt pgfgdsldns psfeiisdyi rhqydeille 121 esrvrrnprf kdgrvhccly linptghglk eidvefirql gslvniipvi sksdsltrde 181 lklnkklime didrwnlpiy nfpfdedeis dedyetnmyl rtllpfaiig snevyemggd 241 vgtirgrkyp wgildvedss isdfvilrna llishlhdlk nytheilyer yrtealsges 301 vaaesirpnl tklngsssss tttrrntnpf kqsnninndv lnpasdmhgq stgennetym 361 treeqirlee erlkafeerv qqelllkrqe llqrekelre iearlekeak ikqee // LOCUS NP_012611 311 aa linear PLN 30-JUN-2025 DEFINITION Mir1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012611 VERSION NP_012611.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181735.1 REFERENCE 1 (residues 1 to 311) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 311) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 311) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 311) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08863. Method: conceptual translation. FEATURES Location/Qualifiers source 1..311 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..311 /product="Mir1p" /calculated_mol_wt="32681" Region 22..105 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 111..200 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 210..299 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..311 /gene="MIR1" /locus_tag="YJR077C" /coded_by="NM_001181735.1:1..936" /experiment="EXISTENCE:direct assay:GO:0005315 phosphate transmembrane transporter activity [PMID:9099701]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:11914276|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8245029]" /experiment="EXISTENCE:direct assay:GO:0035435 phosphate ion transmembrane transport [PMID:9099701]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="Mitochondrial phosphate carrier; imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated" /db_xref="GeneID:853540" /db_xref="SGD:S000003838" ORIGIN 1 msvsaapaip qysvsdymkf alagaigcgs thssmvpidv vktriqlept vynkgmvgsf 61 kqiiagegag alltgfgptl lgysiqgafk fggyevfkkf fidnlgydta sryknsvymg 121 saamaeflad ialcpleatr irlvsqpqfa nglvggfsri lkeegigsfy sgftpilfkq 181 ipyniakflv ferasefyyg fagpkeklss tsttllnlls gltaglaaai vsqpadtlls 241 kvnktkkapg qstvgllaql akqlgffgsf aglptrlvmv gtltslqfgi ygslkstlgc 301 pptieigggg h // LOCUS NP_012612 453 aa linear PLN 30-JUN-2025 DEFINITION dioxygenase BNA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012612 VERSION NP_012612.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181736.3 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 453) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08864. On Jul 30, 2012 this sequence version replaced NP_012612.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..453 /product="dioxygenase BNA2" /EC_number="1.13.11.52" /calculated_mol_wt="50644" Region 23..444 /region_name="IDO" /note="Indoleamine 2,3-dioxygenase; pfam01231" /db_xref="CDD:460123" CDS 1..453 /gene="BNA2" /locus_tag="YJR078W" /coded_by="NM_001181736.3:1..1362" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0033754 indoleamine 2,3-dioxygenase activity [PMID:21170645]" /experiment="EXISTENCE:genetic interaction:GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan [PMID:12062417]" /note="Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD+ from tryptophan via kynurenine; up-regulated by telomere uncapping, and interacts genetically with capping gene CDC13; overexpression reduces lipid droplet accumulation by skewing glycolytic flux towards biosynthesis of shikimate, aromatic amino acids, and NAD+ during aging and extends lifespan; regulated by Hst1p and Aftp" /db_xref="GeneID:853541" /db_xref="SGD:S000003839" ORIGIN 1 mnntsitgpq vlhrtkmrpl pvlekycisp hhgflddrlp ltrlsskkym kweeivadlp 61 sllqednkvr svidgldvld ldetilgdvr elrraysilg fmahayiwas gtprdvlpec 121 iarplletah ilgvpplaty sslvlwnfkv tdeckktetg cldlenitti ntftgtvdes 181 wfylvsvrfe kigsaclnhg lqilrairsg dkgdanvidg leglaatier lskalmemel 241 kcepnvfyfk irpflagwtn mshmglpqgv rygaegqyri fsggsnaqss liqtldillg 301 vkhtanaahs sqgdskinyl demkkympre hreflyhles vcnireyvsr nasnralqea 361 ygrcismlki frdnhiqivt kyiilpsnsk qhgsnkpnvl spiepntkas gclghkvass 421 ktigtggtrl mpflkqcrde tvatadikne dkn // LOCUS NP_012613 109 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR079W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012613 VERSION NP_012613.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181737.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 109) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08865. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..109 /product="uncharacterized protein" /calculated_mol_wt="12465" CDS 1..109 /locus_tag="YJR079W" /coded_by="NM_001181737.1:1..330" /note="hypothetical protein; mutation results in impaired mitochondrial respiration" /db_xref="GeneID:853542" /db_xref="SGD:S000003840" ORIGIN 1 mkikidiihf inappfffff vdaeasqlka fqlfllghif ytyihtyicd fdefetkdla 61 egkigdlisr lefcsnaiie slpntfqsfv pvkfstdkll eeskglldv // LOCUS NP_012614 394 aa linear PLN 30-JUN-2025 DEFINITION Aim24p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012614 VERSION NP_012614.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181738.1 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 394) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08866. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..394 /product="Aim24p" /calculated_mol_wt="44297" Region 49..322 /region_name="AIM24" /note="Mitochondrial biogenesis AIM24; pfam01987" /db_xref="CDD:460407" CDS 1..394 /gene="AIM24" /locus_tag="YJR080C" /gene_synonym="FMP26" /coded_by="NM_001181738.1:1..1185" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:24714493]" /experiment="EXISTENCE:mutant phenotype:GO:0007007 inner mitochondrial membrane organization [PMID:24714493]" /note="Protein with a role in determining mitochondrial architecture; inner membrane protein that interacts physically and genetically with the MICOS complex and is required for its integrity" /db_xref="GeneID:853543" /db_xref="SGD:S000003841" ORIGIN 1 misprvntrv wqrsisllsp qaaktesnvv tkertyienl skdiatsrfr lvdengkias 61 itvqpdipic ikkdclvsih nlnhlslsyk wlnfwsnlik frsfksslfh riigssvlei 121 laapnfqtsr rpfdssrsls vlnltgtkdw nvfgkdsiia feqnssleik spifpsarsl 181 vsnssksqlp rkfqilngrg nvlvcggglv ysielidesd kilvnsrnil aingqsqldi 241 ansverqelh vegayvgdss ndtvapkfik nqtlksaygh tvqffkrmrs wirnqyekry 301 iygvdsyfmk ikgprtiliq themttskdn iltkltskgh vkksnvndng vnlekqvand 361 vnskiielan rpslfiatvs qdgrvdfqst skft // LOCUS NP_012615 113 aa linear PLN 30-JUN-2025 DEFINITION Eaf6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012615 VERSION NP_012615.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181739.3 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 113) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08867. On Jul 30, 2012 this sequence version replaced NP_012615.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..113 /product="Eaf6p" /calculated_mol_wt="12764" Region 14..103 /region_name="NuA4" /note="Histone acetyltransferase subunit NuA4; pfam09340" /db_xref="CDD:462763" CDS 1..113 /gene="EAF6" /locus_tag="YJR082C" /coded_by="NM_001181739.3:1..342" /experiment="EXISTENCE:curator inference:GO:0004402 histone acetyltransferase activity [PMID:17157260]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0033100 NuA3 histone acetyltransferase complex [PMID:17157260]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]" /experiment="EXISTENCE:direct assay:GO:1990467 NuA3a histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:direct assay:GO:1990468 NuA3b histone acetyltransferase complex [PMID:25104842]" /note="Subunit of the NuA4 acetyltransferase complex; this complex acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3" /db_xref="GeneID:853544" /db_xref="SGD:S000003842" ORIGIN 1 mtdelksyea lkaelkkslq drreqedtfd nlqqeiydke teyfshnsnn nhsghggahg 61 skshysgnii kgfdtfsksh hshadsafnn ndrifslssa tyvkqqhgqs qnd // LOCUS NP_012616 309 aa linear PLN 30-JUN-2025 DEFINITION Acf4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012616 VERSION NP_012616.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181740.1 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 309) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08868. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..309 /product="Acf4p" /calculated_mol_wt="35390" CDS 1..309 /gene="ACF4" /locus_tag="YJR083C" /coded_by="NM_001181740.1:1..930" /note="hypothetical protein; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate" /db_xref="GeneID:853545" /db_xref="SGD:S000003843" ORIGIN 1 msedqrvisq pielhklsiv dkhsqgqqqq phqkqhevqp esksprvttp lkpkrlaipi 61 sspqrsttnq spvsdhaspi stdqdliykl aakhreinel sfklevaqke lkqlelqfkd 121 tlprngqqkl gnqnpseyls tftkriqqtf vdvnnspnml kgkksindff skpnnnvnsn 181 inntlpnrkp npppnrsqrm qniapsrsse stptsgppll pprntmknan ttatagentp 241 flqrilnkfn qmnmeedefd dllekrkskk dhyyikenlg yeydevrsed eddeefepmg 301 dipvhlfkr // LOCUS NP_012617 423 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR084W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012617 VERSION NP_012617.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181741.1 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 423) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08869. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..423 /product="uncharacterized protein" /calculated_mol_wt="49351" Region 1..423 /region_name="COG5600" /note="Transcription-associated recombination protein [DNA replication, recombination, and repair]" /db_xref="CDD:227887" CDS 1..423 /locus_tag="YJR084W" /gene_synonym="CSN12" /coded_by="NM_001181741.1:1..1272" /experiment="EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:21149575]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:19061648]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:12446563]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:12446563]" /note="Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome" /db_xref="GeneID:853546" /db_xref="SGD:S000003844" ORIGIN 1 mdvdigcyfe ekryddklld firydvktpk ktkyilqrpt atdeesvrlq rfyqlgvdlk 61 lkyskrrslk kqgriknate ellrlaneql klfnrivere tnwiiyplwv makqlirlan 121 esselnkdsi eecgrtihrs fticlndrnp rlnenkkigc ymfanlefsi yhrlsnkdmi 181 knlvkvlesr vnardippln kslamehksq vvlynyylgq yygclendhe rgffhlneal 241 lqcpmlyves tgkfvlqgqm ekimillvpl alltkrlyph wdhpviagvi trskrlsqvy 301 ptlvrsvisg nlslyeataa sherfflsqg lhvvitllre vvftrlvqrc wqwgndrksi 361 mplkillatk qhdssanede eeqldalecr lasaiasgll raylshsnrc ivfskkepfp 421 hsk // LOCUS NP_012618 105 aa linear PLN 30-JUN-2025 DEFINITION Tmh11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012618 VERSION NP_012618.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181742.3 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 105) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08870. On Jul 30, 2012 this sequence version replaced NP_012618.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..105 /product="Tmh11p" /calculated_mol_wt="11119" Region 4..93 /region_name="Tmemb_14" /note="Transmembrane proteins 14C; pfam03647" /db_xref="CDD:461004" CDS 1..105 /gene="TMH11" /locus_tag="YJR085C" /coded_by="NM_001181742.3:1..318" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="Mitochondrial hypothetical protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853547" /db_xref="SGD:S000003845" ORIGIN 1 mehpaytlsl lttagglmgy yrkgsipslv sglvfgsvyg iagyllhmnr dgglemalga 61 stlllgagvi rgmpsrftkp vpvvltalgg lgsyyyynky kefyp // LOCUS NP_012619 110 aa linear PLN 30-JUN-2025 DEFINITION Ste18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012619 VERSION NP_012619.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181743.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 110) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08871. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..110 /product="Ste18p" /calculated_mol_wt="12494" Region 28..110 /region_name="G-gamma" /note="GGL domain; pfam00631" /db_xref="CDD:459879" CDS 1..110 /gene="STE18" /locus_tag="YJR086W" /coded_by="NM_001181743.1:1..333" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8995254]" /experiment="EXISTENCE:direct assay:GO:0005834 heterotrimeric G-protein complex [PMID:8995254]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8995254]" /experiment="EXISTENCE:direct assay:GO:0031680 G-protein beta/gamma-subunit complex [PMID:8417317|PMID:8995254]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0120171 Cdc24p-Far1p-Gbetagamma complex [PMID:10087263]" /experiment="EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:2107073]" /experiment="EXISTENCE:genetic interaction:GO:0031680 G-protein beta/gamma-subunit complex [PMID:8417317]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3151178]" /experiment="EXISTENCE:mutant phenotype:GO:0005834 heterotrimeric G-protein complex [PMID:2105453]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:8649369]" /experiment="EXISTENCE:physical interaction:GO:0031680 G-protein beta/gamma-subunit complex [PMID:8649369]" /experiment="EXISTENCE:physical interaction:GO:0031681 G-protein beta-subunit binding [PMID:8649369|PMID:8417317]" /note="G protein gamma subunit; forms dimer with Ste4p to activate mating signaling pathway, heterotrimer with Gpa1p, Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling; N-terminal phosphorylation of Ste18p functions synergistically with Fus3p docking site on Ste5p to restrict Ste5p plasma membrane recruitment and signaling; combinatorial phosphorylation at S3 and S7, by pheromone and pH stress, modulates Ste18p structure, Fus3p activation" /db_xref="GeneID:853548" /db_xref="SGD:S000003846" ORIGIN 1 mtsvqnsprl qqpqeqqqqq qqlslkikql klkrinelnn klrkelsrer itasnaclti 61 inytsntkdy tlpelwgypv agsnhfiegl knaqknsqms nsnsvcctlm // LOCUS NP_012621 292 aa linear PLN 30-JUN-2025 DEFINITION Emc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012621 VERSION NP_012621.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181745.1 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 292) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08872. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..292 /product="Emc2p" /calculated_mol_wt="33724" Region 160..>246 /region_name="NrfG" /note="Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]; COG4235" /db_xref="CDD:443378" Region 163..191 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 196..236 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..292 /gene="EMC2" /locus_tag="YJR088C" /coded_by="NM_001181745.1:1..879" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0072546 EMC complex [PMID:19325107]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]" /note="Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm Y57G7A.10/EMC-2, fly CG17556, human TTC35" /db_xref="GeneID:853550" /db_xref="SGD:S000003848" ORIGIN 1 mlkdlvrekl ltimntkayt qfnpeqllql enemkiymks gdsaltegny fflmemlfyv 61 lvyrnqdvda qvvyntlrdr lgensykmvi mkatllqing ndkgaieyle nllnddleye 121 tdfvtyvsia kkliaiktts knlsqesvlk evvaltdkfp ldaelwwyas eiyfemgqfe 181 kacycleqvl citpfnyacf grlsetlyye alrskkqtkt ellekalkna lrsvelsely 241 lkgwalvnii srelgrnkqn dliklsaskl keisaksnnk dkitaeliln ki // LOCUS NP_012622 954 aa linear PLN 30-JUN-2025 DEFINITION survivin [Saccharomyces cerevisiae S288C]. ACCESSION NP_012622 VERSION NP_012622.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181746.3 REFERENCE 1 (residues 1 to 954) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 954) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 954) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 954) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 954) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 954) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 954) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08873. On Jul 30, 2012 this sequence version replaced NP_012622.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..954 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..954 /product="survivin" /calculated_mol_wt="108537" Region 18..>76 /region_name="BIR" /note="Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes; cl00035" /db_xref="CDD:469588" Region 151..241 /region_name="BIR" /note="Baculoviral inhibition of apoptosis protein repeat; smart00238" /db_xref="CDD:197595" Site order(185,205,207,214..216,218,222,227,231..232) /site_type="active" /note="peptide binding groove [active]" /db_xref="CDD:237989" Site order(208,211,228,237) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:237989" CDS 1..954 /gene="BIR1" /locus_tag="YJR089W" /coded_by="NM_001181746.3:1..2865" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16608876]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16608876]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:16381814]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0032133 chromosome passenger complex [PMID:19158380]" /experiment="EXISTENCE:direct assay:GO:0051233 spindle midzone [PMID:16381814]" /experiment="EXISTENCE:genetic interaction:GO:0000776 kinetochore [PMID:10557299]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:16381814]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:16608876]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:10557299]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:22908045]" /experiment="EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:19528231]" /note="Subunit of chromosomal passenger complex (CPC); CPC is comprised of Ipl1p-Sli15p-Bir1p-Nbl1p and regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension; relative distribution to shortened microtubules increases upon DNA replication stress; sumoylated in an Mms21p-dependent manner; human survivin homolog" /db_xref="GeneID:853551" /db_xref="SGD:S000003849" ORIGIN 1 mdgqidkmek rysmtklenr lrtfqdgval ekkklkwsfk vipyqamakl gfyfdpvidp 61 ktsklkkdsv rccychrqty nvrdcrskrk dvletlsnim rqhltvtdnk qvclliylrn 121 klltdysfhm gvsdwkndky fsnpddenvi nlrkftfqdn wphsgsqneh plgiekmvna 181 glmrydssie glgdpsmdkt lmndtcyciy ckqllqgwsi nddpmsrhyk vsqngncyff 241 qtrnrferik ndndsitknc evsptlgeng krevintkta sqrqcplfes ppsstgpqld 301 dynektdisv iqhnisvldg aqgenvkrns veekeqinme ngsttleegn inrdvladkk 361 evistptake ikrpnvqltq ssspikkkrk fkrisprkif deedsehsln nnsangdnkd 421 kdlvidftsh iiknrdvgrk nailddstde fsfsnqghnt fdipiptssh llkgidsdnd 481 nvireddtgi ntdtkgassk hekfsvnsee dlnfsevklt grdsstnili rtqivdqnlg 541 didrdkvpng gspevpkthe lirdnsekre aqngefrhqk dstvrqspdi lhsnksgdns 601 snitaipkee qrrgnsktss ipadihpkpr knlqeprsls isgkvvpter kldninidln 661 fsasdfspss qseqssksss vistpvaspk inltrslhav kelsglkket ddgkyftnkq 721 etikiledvs vknetpnnem llfetgtpia sqenksrklf deefsgkeld ipidsstvei 781 kkvikpefep vpsvarnlvs gtssyprnsr leeqrketst sladnskkgs sfnegnneke 841 pnaaewfkid enrhlvknyf hdllkyinnn datlandkdg dlaflikqmp aeeldmtfnn 901 wvnlkvqsik refiddcdkk ldilrrdyyt atnfietled dnqlidiakk mgil // LOCUS NP_012623 1151 aa linear PLN 30-JUN-2025 DEFINITION SCF ubiquitin ligase complex subunit GRR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012623 VERSION NP_012623.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181747.1 REFERENCE 1 (residues 1 to 1151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1151) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08874. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1151 /product="SCF ubiquitin ligase complex subunit GRR1" /calculated_mol_wt="132603" Region 320..361 /region_name="F-box-like" /note="pfam12937" /db_xref="CDD:463757" Region 404..559 /region_name="AMN1" /note="Antagonist of mitotic exit network protein 1; cd09293" /db_xref="CDD:187754" Region 416..441 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 442..467 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 494..519 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 520..545 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 546..574 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region <574..737 /region_name="AMN1" /note="Antagonist of mitotic exit network protein 1; cd09293" /db_xref="CDD:187754" Region 575..600 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 601..626 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 627..652 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 653..677 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 678..704 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 707..732 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" CDS 1..1151 /gene="GRR1" /locus_tag="YJR090C" /gene_synonym="CAT80; COT2; RMR3; SDC1; SSU2" /coded_by="NM_001181747.1:1..3456" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:15775961|PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:10213692]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:9819356|PMID:9346238|PMID:11259599]" /experiment="EXISTENCE:genetic interaction:GO:0000209 protein polyubiquitination [PMID:9499404]" /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:16093347]" /experiment="EXISTENCE:mutant phenotype:GO:0000751 mitotic cell cycle G1 arrest in response to pheromone [PMID:15942932]" /experiment="EXISTENCE:mutant phenotype:GO:0019005 SCF ubiquitin ligase complex [PMID:9736614]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:9819356]" /experiment="EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:29212878]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:29212878]" /experiment="EXISTENCE:mutant phenotype:GO:0071406 cellular response to methylmercury [PMID:17141224]" /experiment="EXISTENCE:physical interaction:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:10213692]" /note="F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF(Grr1) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as: Gic2p, Mks1p, Mth1p, Cln1p, Cln2p and Cln3p; involved in carbon catabolite repression, glucose-dependent divalent cation transport, glucose transport, morphogenesis, and sulfite detoxification" /db_xref="GeneID:853552" /db_xref="SGD:S000003850" ORIGIN 1 mdqdnnnhnd snrlhppdih pnlgpqlwln ssgdfddnnn nnnnnnnnns trpqmpsrtr 61 etatsernas evrdatlnni frfdsiqret llptnngqpl nqnfsltfqp qqqtnalngi 121 dintvntnlm ngvnvqidql nrllpnlpee erkqihefkl ivgkkiqefl vviekrrkki 181 lneieldnlk lkelridnsp qaisylhklq rmrlralete nmeirnlrlk iltiieeykk 241 slyaychskl rgqqvenptd nfiiwinsid ttessdlkeg lqdlsrysrq finnvlsnps 301 nqnictsvtr rspvfalnml pseilhlild klnqkydivk fltvsklwae iivkilyyrp 361 hinkksqldl flrtmkltse etvfnyrlmi krlnfsfvgd ymhdtelnyf vgcknlerlt 421 lvfckhitsv pisavlrgck flqsvditgi rdvsddvfdt latycprvqg fyvpqarnvt 481 fdslrnfivh spmlkrikit annnmndelv ellankcpll vevditlspn vtdssllkll 541 trlvqlrefr ithntnitdn lfqelskvvd dmpslrlidl sgcenitdkt iesivnlapk 601 lrnvflgkcs ritdaslfql sklgknlqtv hfghcfnitd ngvralfhsc triqyvdfac 661 ctnltnrtly eladlpklkr iglvkctqmt degllnmvsl rgrndtlerv hlsycsnlti 721 ypiyellmsc prlshlslta vpsflrpdit mycrpapsdf senqrqifcv fsgkgvhklr 781 hylvnltspa fgphvdvndv ltkyirsknl ifngetleda lrriitdlnq dsaaiiaatg 841 lnqinglnnd flfqninfer idevfswyln tfdgirmsse evnslllqvn ktfcedpfsd 901 vdddqdyvva pgvnreinse mchivrkfhe lndhiddfev nvaslvrvqf qftgfllhem 961 tqtymqmiel nrqiclvqkt vqesgnidyq kglliwrllf idkfimvvqk yklstvvlrl 1021 ylkdnitllt rqrelliahq rsawnnnndn danrnanniv nivsdagand tsnnetnngn 1081 ddnetenpnf wrqfgnrmqi spdqmrnlqm glrnqnmvrn nnnntidesm pdtaidsqmd 1141 easgtpdedm l // LOCUS NP_012624 1091 aa linear PLN 30-JUN-2025 DEFINITION Jsn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012624 VERSION NP_012624.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181748.1 REFERENCE 1 (residues 1 to 1091) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1091) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1091) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1091) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1091) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08875. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1091 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1091 /product="Jsn1p" /calculated_mol_wt="120244" Region 58..920 /region_name="COG5099" /note="RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]" /db_xref="CDD:227430" CDS 1..1091 /gene="JSN1" /locus_tag="YJR091C" /gene_synonym="PUF1" /coded_by="NM_001181748.1:1..3276" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21685478|PMID:15024427|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0032473 cytoplasmic side of mitochondrial outer membrane [PMID:16107558]" /experiment="EXISTENCE:genetic interaction:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11101532]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:16107558]" /experiment="EXISTENCE:mutant phenotype:GO:0051654 establishment of mitochondrion localization [PMID:16107558]" /note="Member of the Puf family of RNA-binding proteins; interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl; JSN1 has a paralog, PUF2, that arose from the whole genome duplication" /db_xref="GeneID:853553" /db_xref="SGD:S000003851" ORIGIN 1 mdkskqmnin nlsnipevid pgitipiyee eyenngesns qlqqqpqklg syrsragkfs 61 ntlsnllpsi saklhhskkn shgkngaefs ssnnssqstv asktprasps rskmmessid 121 gvtmdrpgsl tppqdmeklv hfpdssnnfl ipaprgssds fnlphqisrt rnntmssqit 181 sissiapkpr tssgiwssna sandpmqqhl lqqlqpttsn nttnsntlnd ystktayfdn 241 mvstsgsqma dnkmntnnla ipnsvwsntr qrsqsnassi ytdaplyeqp arasisshyt 301 iptqesplia deidpqsinw vtmdptvpsi nqisnllptn tisisnvfpl qhqqpqlnna 361 inltstslat lcskygevis artlrnlnma lvefssvesa vkaldslqgk evsmigapsk 421 isfakilpmh qqppqfllns qglplglenn nlqpqpllqe qlfngavtfq qqgnvsipvf 481 nqqsqqsqhq nhssgsagfs nvlhgynnnn smhgnnnnsa nekeqcpfpl pppnvneked 541 llreiielfe ansdeyqins likkslnhkg tsdtqnfgpl peplsgrefd ppklrelrks 601 idsnafsdle ieqlaiamld elpelssdyl gntivqklfe hssdiikdim lrktskylts 661 mgvhkngtwa cqkmitmaht prqimqvtqg vkdyctplin dqfgnyviqc vlkfgfpwnq 721 fifesiianf wvivqnryga ravracleah divtpeqsiv lsamivtyae ylstnsngal 781 lvtwfldtsv lpnrhsilap rltkrivelc ghrlasltil kvlnyrgddn arkiildslf 841 gnvnahdssp pkeltkllce tnygptfvhk vlamplledd lrahiikqvr kvltdstqiq 901 psrrlleevg laspssthnk tkqqqqqhhn ssishmfatp dtsgqhmrgl svssvksggs 961 khttmntttt ngssastlsp gqplnansns smgyfsypgv fpvsgfsgna sngyamnndd 1021 lssqfdmlnf nngtrlslpq lsltnhnntt melvnnvgss qphtnnnnnn nntnynddnt 1081 vfetltlhsa n // LOCUS NP_012625 1447 aa linear PLN 30-JUN-2025 DEFINITION Bud4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012625 VERSION NP_012625.5 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181749.3 REFERENCE 1 (residues 1 to 1447) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1447) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1447) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1447) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08876. On Jul 30, 2012 this sequence version replaced NP_012625.4. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1447 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1447 /product="Bud4p" /calculated_mol_wt="164356" Region 1285..1424 /region_name="PH_Bud4" /note="Bud4 Pleckstrin homology (PH) domain; cd13278" /db_xref="CDD:241432" CDS 1..1447 /gene="BUD4" /locus_tag="YJR092W" /coded_by="NM_001181749.3:1..4344" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:22553209]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:22553209]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:23345395]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:27385335|PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0005525 GTP binding [PMID:22553209]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:22553209]" /experiment="EXISTENCE:mutant phenotype:GO:0031106 septin ring organization [PMID:23345395]" /experiment="EXISTENCE:mutant phenotype:GO:0097271 protein localization to bud neck [PMID:22553209]" /note="Anillin-like protein involved in bud-site selection; required for the axial budding pattern; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; functions as a platform linking the cytokinesis tag septins to the axial landmark through its multiple domains; in vivo substrate of Cdc28p/Clb2p" /db_xref="GeneID:853554" /db_xref="SGD:S000003852" ORIGIN 1 mhdaestvds llkeidneme qtksnitqng sedtphnwkl plqeigddtm emlvkhntrs 61 natensrgrs pskmstisne slnlgllrvn seleespaav hqeriknsva ngalghansp 121 kvlnnlknma qdidklarde ekpvklsssp lkftlkstqp llsypespih rssieietny 181 ddedeeeeda ytcltqspqi lhspsripit navsinklnl dftlnpnesd kslvsdtsvd 241 stgreldtkt ipelpfcmss tpemtpvdek cnlpskllnt snnshsdsrs ptasvedlni 301 stnlpgadss qnnpvttdad aliendvvrd lqqnmehidd afdekkvlde gcsnepvtfl 361 gendtrsivy snkgtnanvq efsqedslah sepkfkdlna tsddvwnedk etdanistst 421 kseesyiady kvtrqedwdt kklhqeseha neqpaiipqk dsseetftel nnesefqrnf 481 kdgeeyrivq heeslygqrt kspeeniing seigvdhgea aevneplakt saeehdlsss 541 cedqsvsear nkdrieekev etkdeniete kdeseyhkve eneepehvpl lpplprweei 601 qfnepfiden dtsndsidlt rsmkpsdyis iwhiqeeeik snspesians qfsqqssitt 661 astvdskkdn gstsfkfkpr ivsrsriynp ksrvsslnyy dnedyilsns ewnaldpmrr 721 ntliskriqd nirtqkghap lirpsimkln gedsgfqnhf leveqpqehe niplsthlse 781 qdittnvgld eqklptntqd eaeisireie sagditfnrg dllslsfdee lgqdfanfld 841 aldhdstsfn hgpddsssfq rdsskksfns lwessyelkp ppsirkqpia pdvlqklles 901 dtkddadlek ireeritepr tglgigmlkt pvkdvsiala asikgyeasf sdtdsrpegm 961 nnsdaitlnm fddfeedkmt pstpvrsisp ikrhvsspfk vvkagnkqen neinikaeee 1021 iepmtqqetd glkqdippll aqtkdnveak eetitqleep qdveqefpdm gtlylsikai 1081 stlalygtks hratyaivfd ngenvvqtpw eslpydgnir inkefelpid fkgkaetssa 1141 sserdsykkc vitlkckyek prhelveivd kvpvgksffg ktkykfekky vqkkpkqdew 1201 dylfaqdgsf arceieinee flknvafnts hmhynminkw sriadkihgs krlyelprka 1261 phkvasldve acflertsaf eqfpkqfslv nkivskyklq qniykegyll qdggdlkgki 1321 enrffklhgs qlsgyheisr kakidinllk vtkvlrnedi qadnggqrnf tdwvlfnecf 1381 qlvfddgeri tfnaecsnee ksdwynklqe vvelnvfhqp wvkkycekla eeektrttgh 1441 nlkqdfn // LOCUS NP_012626 327 aa linear PLN 30-JUN-2025 DEFINITION cleavage polyadenylation factor subunit FIP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012626 VERSION NP_012626.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181750.1 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 327) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08877. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..327 /product="cleavage polyadenylation factor subunit FIP1" /calculated_mol_wt="35646" Region 8..301 /region_name="FIP1" /note="Polyadenylation factor I complex, subunit FIP1 [RNA processing and modification]; COG5213" /db_xref="CDD:227538" CDS 1..327 /gene="FIP1" /locus_tag="YJR093C" /coded_by="NM_001181750.1:1..984" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11344258]" /experiment="EXISTENCE:genetic interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:21282348]" /experiment="EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:11238938]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:21282348]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:7736590]" /note="Subunit of cleavage polyadenylation factor (CPF); interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p" /db_xref="GeneID:853555" /db_xref="SGD:S000003853" ORIGIN 1 msssededdk flygsdsela lpsskrsrdd eadagassnp divkrqkfds pveetpatar 61 ddrsdediys dssdddsdsd leviislgpd ptrldaklld systaatsss kdvisvatdv 121 sntitktsde rlitegeanq gvtattvkat esdgnvpkam tgsidldkeg ifdsvgitti 181 dpevlkekpw rqpganlsdy fnygfneftw meylhrqekl qqdynprril mgllslqqqg 241 klnsandtds nlgniidnnn nvnnanmsnl nsnmgnsmsg tpnppappmh psfpplpmfg 301 sfppfpmpgm mppmnqqpnq nqnqnsk // LOCUS NP_012627 360 aa linear PLN 30-JUN-2025 DEFINITION transcription factor IME1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012627 VERSION NP_012627.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181751.1 REFERENCE 1 (residues 1 to 360) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 360) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 360) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 360) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08878. Method: conceptual translation. FEATURES Location/Qualifiers source 1..360 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..360 /product="transcription factor IME1" /calculated_mol_wt="41727" CDS 1..360 /gene="IME1" /locus_tag="YJR094C" /coded_by="NM_001181751.1:1..1083" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8462841]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:29472539]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:8205723]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:20876298]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:8205723]" /experiment="EXISTENCE:mutant phenotype:GO:0043934 sporulation [PMID:9660952]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9660952]" /experiment="EXISTENCE:physical interaction:GO:0008134 transcription factor binding [PMID:8628320]" /note="Master meiotic regulator active only during meiotic events; activates transcription of early meiotic genes through interaction with Ume6p; regulator of meiotic commitment; phosphorylated by Rim11p; degraded by the 26S proteasome following phosphorylation by Ime2p; transcription is negatively regulated in cis by the IRT1 long noncoding antisense RNA" /db_xref="GeneID:853556" /db_xref="SGD:S000003854" ORIGIN 1 mqadmhgklh aaledgfflf pfeqqqqpni yydtttdqed rpcfsfgsti sprswhfeks 61 dkiassqlqn lvhtqpihli npqilfneef lnlenidsqp isketkttkd ctmatgperg 121 kkssestrss slsslfsnde sastfhssfn nhdnfqksnr ngddidisdt ikyetntnaq 181 kdikifqenf efnefpytqd fypyttnyty skptnihesi nskntdsysq yqdqfpphtd 241 nihsfnnrhy snhkstncny ynntsnnnna sdnvyeadpf idepqvpsyy ypleiafdve 301 kspppslqkl nskeleflkk lnsklsryaa aysfsssndq dyydkvrfqe isykfsktys // LOCUS NP_012628 92 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL43 RPL43B [Saccharomyces cerevisiae S288C]. ACCESSION NP_012628 VERSION NP_012628.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181752.3 REFERENCE 1 (residues 1 to 92) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 92) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 92) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 92) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08879. On Jul 30, 2012 this sequence version replaced NP_012628.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..92 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..92 /product="60S ribosomal protein eL43 RPL43B" /calculated_mol_wt="9960" Region 1..88 /region_name="PTZ00255" /note="60S ribosomal protein L37a; Provisional" /db_xref="CDD:240332" CDS 1..92 /gene="RPL43B" /locus_tag="YJR094W-A" /coded_by="NM_001181752.3:1..279" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853557" /db_xref="SGD:S000003855" ORIGIN 1 makrtkkvgi tgkygvrygs slrrqvkkle iqqharydcs fcgkktvkrg aagiwtcscc 61 kktvaggayt vstaaaatvr stirrlremv ea // LOCUS NP_012629 322 aa linear PLN 30-JUN-2025 DEFINITION Sfc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012629 VERSION NP_012629.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181753.1 REFERENCE 1 (residues 1 to 322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 322) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08880. Method: conceptual translation. FEATURES Location/Qualifiers source 1..322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..322 /product="Sfc1p" /calculated_mol_wt="35209" Region 6..103 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 108..206 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 210..304 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..322 /gene="SFC1" /locus_tag="YJR095W" /gene_synonym="ACR1" /coded_by="NM_001181753.1:1..969" /experiment="EXISTENCE:direct assay:GO:0005469 succinate:fumarate antiporter activity [PMID:9395087]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015741 fumarate transport [PMID:9395087]" /experiment="EXISTENCE:direct assay:GO:0015744 succinate transport [PMID:9395087]" /note="Mitochondrial succinate-fumarate transporter; transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization" /db_xref="GeneID:853558" /db_xref="SGD:S000003856" ORIGIN 1 msqkkkashp ainlmaggta glfealcchp ldtikvrmqi yrrvagiehv kppgfiktgr 61 tiyqkegfla lykglgavvi giipkmairf ssyefyrtll vnkesgivst gntfvagvga 121 giteavlvvn pmevvkirlq aqhltpsepn agpkynnaih aaytivkeeg vsalyrgvsl 181 taarqatnqg anftvysklk eflqnyhqmd vlpswetsci glisgaigpf snapldtikt 241 rlqkdksisl ekqsgmkkii tigaqllkee gfralykgit prvmrvapgq avtftvyeyv 301 rehlenlgif kkndtpkpkp lk // LOCUS NP_012630 282 aa linear PLN 30-JUN-2025 DEFINITION aldo-keto reductase superfamily protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012630 VERSION NP_012630.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181754.1 REFERENCE 1 (residues 1 to 282) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 282) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 282) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 282) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08881. Method: conceptual translation. FEATURES Location/Qualifiers source 1..282 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..282 /product="aldo-keto reductase superfamily protein" /calculated_mol_wt="32213" Region 14..266 /region_name="AKR_AKR1-5-like" /note="AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; cd19071" /db_xref="CDD:381297" Site order(20..22,45,50,81,115..116,146..147,170,196..202,222, 237..240,245,248..249) /site_type="active" /db_xref="CDD:381297" Site order(45,50,81,115) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381297" CDS 1..282 /locus_tag="YJR096W" /coded_by="NM_001181754.1:1..849" /experiment="EXISTENCE:direct assay:GO:0004032 aldose reductase (NADPH) activity [PMID:11306085|PMID:12271459]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0008106 alcohol dehydrogenase (NADP+) activity [PMID:17140678]" /experiment="EXISTENCE:direct assay:GO:0019568 arabinose catabolic process [PMID:12271459]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:17919749]" /experiment="EXISTENCE:mutant phenotype:GO:0019568 arabinose catabolic process [PMID:12271459]" /experiment="EXISTENCE:mutant phenotype:GO:0042843 D-xylose catabolic process [PMID:12271459]" /note="Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:853559" /db_xref="SGD:S000003857" ORIGIN 1 mvpkfyklsn gfkipsialg tydiprsqta eivyegvkcg yrhfdtavly gnekevgdgi 61 ikwlnedpgn hkreeifytt klwnsqngyk rakaairqcl nevsglqyid lllihspleg 121 sklrletwra mqeavdeglv ksigvsnygk khidellnwp elkhkpvvnq ieispwimrq 181 eladyckskg lvveafaplc hgykmtnpdl lkvckevdrn pgqvlirwsl qhgylplpkt 241 ktvkrlegnl aaynfelsde qmkfldhpda yeptdwectd ap // LOCUS NP_012631 172 aa linear PLN 30-JUN-2025 DEFINITION Jjj3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012631 VERSION NP_012631.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181755.3 REFERENCE 1 (residues 1 to 172) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 172) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 172) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 172) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08882. On Jul 30, 2012 this sequence version replaced NP_012631.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..172 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..172 /product="Jjj3p" /calculated_mol_wt="19896" Region 8..73 /region_name="DnaJ" /note="DnaJ domain; pfam00226" /db_xref="CDD:395170" Site order(36..38,50,53..54,57..58) /site_type="other" /note="HSP70 interaction site [polypeptide binding]" /db_xref="CDD:99751" Region 93..164 /region_name="zf-CSL" /note="CSL zinc finger; pfam05207" /db_xref="CDD:398744" CDS 1..172 /gene="JJJ3" /locus_tag="YJR097W" /gene_synonym="DPH4" /coded_by="NM_001181755.3:1..519" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008198 ferrous iron binding [PMID:22367199]" /experiment="EXISTENCE:mutant phenotype:GO:0017183 protein histidyl modification to diphthamide [PMID:15485916]" /note="Iron-binding protein; involved in targeting cytoplasmic SRP-independent proteins to the ER; contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4" /db_xref="GeneID:853560" /db_xref="SGD:S000003858" ORIGIN 1 mslvnslthy eilripsdat qdeikkayrn rllnthpdkl sksihdtvsn vtinkiqday 61 kilsniktrr eydrlileny krqgfhncgd gldefslddf sfdedklefm mncprcqfvg 121 gfhfseslld ecidnvdame rshsgyqllt qcsacslwlk vnfdieeeqe gq // LOCUS NP_012632 656 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR098C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012632 VERSION NP_012632.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181756.2 REFERENCE 1 (residues 1 to 656) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 656) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 656) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 656) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08883. On Apr 26, 2011 this sequence version replaced NP_012632.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..656 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..656 /product="uncharacterized protein" /calculated_mol_wt="74104" Region 308..389 /region_name="EstA" /note="Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism]; COG1075" /db_xref="CDD:440693" CDS 1..656 /locus_tag="YJR098C" /coded_by="NM_001181756.2:1..1971" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:853561" /db_xref="SGD:S000003859" ORIGIN 1 mmatpatdli sdndkynkqc lsdssdsgsd vsffsvnese geldtmekvd tliggarvis 61 nkvekdsdse qrgrkkettg pnnyhnleek qasaisldad dedldeiisy shdgnydssh 121 ktfsfslpfg ntnfrssspl aiiktvlpkt pdefikknlr kneikqklkk stsissleei 181 elfkyergid nsrlravkes lemdalknsi kqitadpfdk thdgyyrsrl esiwnelegd 241 vvimggyrgs vlrdatthkr iwiplkagln mtkvdlligp ndedelktqk eivpdgmlth 301 igpvdiskrl ikrldanpnl nvqqfgydwr lsldisakhl ttkleeiynk qknkkgiyii 361 ahsmgglvah kvlqdcthli rgiiyvgsps qcpnilgpir fgddvmwnkt iftketnffm 421 rssfyflpld grcfvdkitl erydfdffdt dvwktlglsp lvnekreesa hekskllprk 481 tksalslkat lnattkfvln apvvrnvagn nkqvprdvpf devfhtsyed sceylartlk 541 rtknyldsld ydpnkeyppl amvygnkvpt vrgakvngiq dikdgnyedf yygpgdgvvh 601 hkwllpeqrg fpvvckiass sghvslmtdl ksmakafisi vdsekegrrs rtrtss // LOCUS NP_012633 236 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease YUH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012633 VERSION NP_012633.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181757.1 REFERENCE 1 (residues 1 to 236) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 236) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 236) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 236) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08884. Method: conceptual translation. FEATURES Location/Qualifiers source 1..236 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..236 /product="ubiquitin-specific protease YUH1" /EC_number="3.4.19.12" /calculated_mol_wt="26254" Region 8..231 /region_name="Peptidase_C12" /note="Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1; cl08306" /db_xref="CDD:471809" Site order(84,90,166,181) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:187736" CDS 1..236 /gene="YUH1" /locus_tag="YJR099W" /coded_by="NM_001181757.1:1..711" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:1429680]" /experiment="EXISTENCE:curator inference:GO:0010992 ubiquitin recycling [PMID:1429680]" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:1429680]" /note="Ubiquitin C-terminal hydrolase; cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p" /db_xref="GeneID:853562" /db_xref="SGD:S000003860" ORIGIN 1 msgenravvp iesnpevftn fahklglkne wayfdiyslt epellaflpr pvkaivllfp 61 inedrkssts qqitssydvi wfkqsvknac glyailhsls nnqsllepgs dldnflksqs 121 dtsssknrfd dvttdqfvln vikenvqtfs tgqseapeat adtnlhyity veenggifel 181 dgrnlsgply lgksdptatd lieqelvrvr vasymenane edvlnfamlg lgpnwe // LOCUS NP_012634 327 aa linear PLN 30-JUN-2025 DEFINITION Aim25p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012634 VERSION NP_012634.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181758.3 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 327) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08885. On Jul 30, 2012 this sequence version replaced NP_012634.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..327 /product="Aim25p" /calculated_mol_wt="37349" Region 59..310 /region_name="Scramblase" /note="pfam03803" /db_xref="CDD:252175" CDS 1..327 /gene="AIM25" /locus_tag="YJR100C" /gene_synonym="SLM35" /coded_by="NM_001181758.3:1..984" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:27922823]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:27922823]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:27922823]" /experiment="EXISTENCE:mutant phenotype:GO:1903147 negative regulation of autophagy of mitochondrion [PMID:27922823]" /note="Mitochondria hypothetical protein; interacts genetically with TOR1 to regulate chronological lifespan, and the response to both heat shock and oxidative stress; involved in maintaining the integrity of the mitochondrial network; negative regulator of mitophagy flux; non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant is viable and displays an elevated frequency of mitochondrial genome loss; similar to murine NOR1" /db_xref="GeneID:853563" /db_xref="SGD:S000003861" ORIGIN 1 mhrtaiflty rscmrnfstl sktltvssgk virngpfrrv ireknqitka psvkafkens 61 nsgiikvhdp iattilnept viierqiefm nvflgfeqan ryaimdvngn kiasmmerdf 121 sitkaimrqf yrlhrpflvd vfdnwgnvim tikrpfsfin shiktiipps ayvdngsdst 181 hyhdgkegtt vgetiqnwhl wrrryelfqk dgvegstfdq fgkidapfls fdfpvtdadg 241 kimasvdrnw vglgremftd tgvyvvrfds qrcfdniypt emlssqvltl dqravllana 301 vsidfdyfsr hsrqtggfls fgggyde // LOCUS NP_012635 266 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS42 RSM26 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012635 VERSION NP_012635.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181759.1 REFERENCE 1 (residues 1 to 266) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 266) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 266) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 266) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08886. Method: conceptual translation. FEATURES Location/Qualifiers source 1..266 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..266 /product="mitochondrial 37S ribosomal protein mS42 RSM26" /calculated_mol_wt="30092" Region 115..259 /region_name="Sod_Fe_C" /note="Iron/manganese superoxide dismutases, C-terminal domain; pfam02777" /db_xref="CDD:460691" CDS 1..266 /gene="RSM26" /locus_tag="YJR101W" /gene_synonym="mS42" /coded_by="NM_001181759.1:1..801" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:853565" /db_xref="SGD:S000003862" ORIGIN 1 mlvfkrgihv vpklpnskal lqngvpnils ssgfktvwfd yqrylcdklt latagqsles 61 yypfhillkt agnplqsnif nlassihnnh lfvenilpsa vehgtnsnav vktepsrlfl 121 skikdsfngs dwevvkeemi yraenevlgq gwlflvenne kklfiltsnn ngtpyyfprn 181 qsfdlnsais idefatlkqm keligkstkl ngkvqdwtmp iicvnlwdha ylhdygvgnr 241 skyvknvldn lnwsvvnnri fsgisk // LOCUS NP_012636 202 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-II subunit protein VPS25 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012636 VERSION NP_012636.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181760.1 REFERENCE 1 (residues 1 to 202) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 202) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 202) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 202) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08887. Method: conceptual translation. FEATURES Location/Qualifiers source 1..202 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..202 /product="ESCRT-II subunit protein VPS25" /calculated_mol_wt="23427" Region 7..163 /region_name="ESCRT-II" /note="ESCRT-II complex subunit; pfam05871" /db_xref="CDD:461763" CDS 1..202 /gene="VPS25" /locus_tag="YJR102C" /gene_synonym="VPL12; VPT25" /coded_by="NM_001181760.1:1..609" /experiment="EXISTENCE:direct assay:GO:0000814 ESCRT II complex [PMID:12194858]" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:15329733|PMID:15469844]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11278625]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:15469844|PMID:15329733]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12194858]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /note="Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome" /db_xref="GeneID:853566" /db_xref="SGD:S000003863" ORIGIN 1 msalppvysf pplytrqpns ltrrqqistw idiisqyckt kkiwymsvdg tvindnelds 61 gstdnddskk isknlfnned iqrsvsqvfi deiwsqmtke gkclpidqsg rrssnttttr 121 yfilwkslds waslilqwfe dsgklnqvit lyelsegdet vnwefhrmpe sllyyclkpl 181 cdrnratmlk dendkviaik vv // LOCUS NP_012637 578 aa linear PLN 30-JUN-2025 DEFINITION CTP synthase URA8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012637 VERSION NP_012637.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181761.4 REFERENCE 1 (residues 1 to 578) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 578) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 578) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 578) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08888. On Jul 30, 2012 this sequence version replaced NP_012637.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..578 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..578 /product="CTP synthase URA8" /EC_number="6.3.4.2" /calculated_mol_wt="64380" Region 1..557 /region_name="PyrG" /note="CTP synthase; TIGR00337" /db_xref="CDD:273021" CDS 1..578 /gene="URA8" /locus_tag="YJR103W" /coded_by="NM_001181761.4:1..1737" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003883 CTP synthase activity [PMID:7559626]" /experiment="EXISTENCE:direct assay:GO:0006241 CTP biosynthetic process [PMID:7559626]" /experiment="EXISTENCE:direct assay:GO:0097268 cytoophidium [PMID:20713603]" /experiment="EXISTENCE:mutant phenotype:GO:0003883 CTP synthase activity [PMID:8121398]" /note="Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication" /db_xref="GeneID:853567" /db_xref="SGD:S000003864" ORIGIN 1 mkyvvvsggv isgigkgvla sstgmllktl glkvtsikid pymnidagtm splehgecfv 61 lddggetdld lgnyerylgi tlsrdhnitt gkiyshvisr errgdylgkt vqivphltna 121 iqdwiqrvsk ipvddtglep dvciielggt vgdiesapfv ealrqfqfev grenfalihv 181 slvpvihgeq ktkptqaaik dlrslglipd miacrcseel nrstidkiam fchvgpeqvv 241 nvhdvnstyh vpllllkqhm idylhsrlkl gevpltledk ergsqlltnw enmtknldds 301 ddvvkialvg kytnlkdsyl svtkslehas mkcrrqleil wveasnlepe tqevdknkfh 361 dswnklssad gilvpggfgt rgiegmilaa kwaresgvpf lgvclglqva aiefarnvig 421 rpnssstefl detllapedq vviympeidk ehmggtmrlg lrptifqpns ewsnirklyg 481 evnevherhr hryeinpkiv ndmesrgfif vgkdetgqrc eifelkghpy yvgtqyhpey 541 tskvlepsrp fwglvaaasg tlgevikdin lsegnene // LOCUS NP_012638 154 aa linear PLN 30-JUN-2025 DEFINITION superoxide dismutase SOD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012638 VERSION NP_012638.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181762.1 REFERENCE 1 (residues 1 to 154) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 154) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 154) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 154) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08889. Method: conceptual translation. FEATURES Location/Qualifiers source 1..154 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..154 /product="superoxide dismutase SOD1" /EC_number="1.15.1.1" /calculated_mol_wt="15723" Region 14..150 /region_name="Sod_Cu" /note="Copper/zinc superoxide dismutase (SODC); pfam00080" /db_xref="CDD:459663" CDS 1..154 /gene="SOD1" /locus_tag="YJR104C" /gene_synonym="CRS4" /coded_by="NM_001181762.1:1..465" /experiment="EXISTENCE:direct assay:GO:0004784 superoxide dismutase activity [PMID:3290902]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18977757|PMID:24647101]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:11500508]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:36630448|PMID:11500508]" /experiment="EXISTENCE:direct assay:GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [PMID:36630448]" /experiment="EXISTENCE:mutant phenotype:GO:0006801 superoxide metabolic process [PMID:3290902]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:8530401]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:11581253]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:20176017]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:24647101]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:24647101]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:23332757]" /experiment="EXISTENCE:mutant phenotype:GO:1901856 negative regulation of cellular respiration [PMID:23332757]" /experiment="EXISTENCE:mutant phenotype:GO:1990748 cellular detoxification [PMID:36630448]" /experiment="EXISTENCE:physical interaction:GO:0050821 protein stabilization [PMID:23332757]" /note="Cytosolic copper-zinc superoxide dismutase; also sulfide oxidase; detoxifies superoxide and hydrogen sulfide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; abundance increases under DNA replication stress; localization to mitochondrial intermembrane space is modulated by MICOS complex; human ortholog SOD1 implicated in ALS complements a null allele" /db_xref="GeneID:853568" /db_xref="SGD:S000003865" ORIGIN 1 mvqavavlkg dagvsgvvkf eqaseseptt vsyeiagnsp naergfhihe fgdatngcvs 61 agphfnpfkk thgaptdevr hvgdmgnvkt dengvakgsf kdslikligp tsvvgrsvvi 121 hagqddlgkg dteeslktgn agprpacgvi gltn // LOCUS NP_012639 340 aa linear PLN 30-JUN-2025 DEFINITION adenosine kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012639 VERSION NP_012639.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181763.1 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 340) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08890. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..340 /product="adenosine kinase" /EC_number="2.7.1.20" /calculated_mol_wt="36241" Region 5..332 /region_name="adenosine_kinase" /note="Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; cd01168" /db_xref="CDD:238573" Site order(10,12,14,34,63..65,68,121,132,134,136,165,196, 289..290,293) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238573" Site order(258,260..261,264,277,279,285,288,291..292,295,320, 324) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238573" CDS 1..340 /gene="ADO1" /locus_tag="YJR105W" /coded_by="NM_001181763.1:1..1023" /experiment="EXISTENCE:direct assay:GO:0004001 adenosine kinase activity [PMID:11223943]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004001 adenosine kinase activity [PMID:11223943]" /experiment="EXISTENCE:mutant phenotype:GO:0006144 purine nucleobase metabolic process [PMID:11223943]" /note="Adenosine kinase; required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle" /db_xref="GeneID:853569" /db_xref="SGD:S000003866" ORIGIN 1 mtaplvvlgn plldfqadvt aeylakyslk endailvdak sgdakmaifd ellqmpetkl 61 vaggaaqnta rgaayvlgag qvvyfgsvgk dkfserllne nekagvksmy qvqndigtgk 121 caalitghnr slvtdlgaan fftpdhldkh wdlveaaklf yiggfhltvs pdaivklgqh 181 akenskpfvl nfsapfiphv fkdalarvlp yatviianes eaeafcdafq ldcantdlea 241 iaqrivkdsp vektvifthg veptvvvssk gtstypvkpl dsskivdtng agdafaggfm 301 agltkgedle tsidmgqwla alsiqevgps ypsekisysk // LOCUS NP_012640 725 aa linear PLN 30-JUN-2025 DEFINITION Ecm27p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012640 VERSION NP_012640.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181764.4 REFERENCE 1 (residues 1 to 725) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 725) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 725) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 725) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08891. On Jul 30, 2012 this sequence version replaced NP_012640.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..725 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..725 /product="Ecm27p" /calculated_mol_wt="80526" Region 27..196 /region_name="Na_Ca_ex" /note="Sodium/calcium exchanger protein; pfam01699" /db_xref="CDD:426387" Region <544..637 /region_name="PLN03151" /note="cation/calcium exchanger; Provisional" /db_xref="CDD:215604" CDS 1..725 /gene="ECM27" /locus_tag="YJR106W" /coded_by="NM_001181764.4:1..2178" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:27242146]" /experiment="EXISTENCE:mutant phenotype:GO:0070316 regulation of G0 to G1 transition [PMID:27242146]" /note="Protein involved in calcium homeostasis and exit from quiescence; required for proper trehalose levels during quiescence; may play a role in cell wall biosynthesis, mutants are hypersensitive to antifungal, Papulacandin B; null mutants have increased plasmid loss; interacts with Pdr5p" /db_xref="GeneID:853570" /db_xref="SGD:S000003867" ORIGIN 1 mdwainvahp rllykdpkls vtfivpslfh iiiafvllgi casdflcpnv ahisdpnslr 61 sngslvskta shashtgalm avllswcnss pdlfsnlmsw atstretrst svslsigevl 121 gacgiilciv egsifiimsr thieisqiqk lsimrdllfs laamcvmsyv slmnqvtvln 181 cllmaflyaf ylvvkltfkl nhsaetpdet aadtslrens vspflddslm asgllppiqp 241 gfdisnsith gikpsllsam dfnsflsmle nssleeddsr nemaelntlr smtpgqhwsa 301 satvageats agrpfseptn afteyrdser ainsspavfa pyrdnpddee sqeqvllett 361 thghfgaqem rrfskrslgw iikifiphls nfsqksisda ifsiitvpff iifklscpqp 421 psdilsydpt lnryslttlp iillfiqsit apfllcsils vlltyhlgyl vylfplilam 481 alillltafi tkvnlhnkft lsldssnilq eklqkrklle rlntsiqiif laigiiniii 541 wisllansli emmeiyqkil glskailglt ifawgnsvgd lisnismcrl yktqthyqdr 601 vrlatkffmi scasclggvm lnsmggigfs glvsmlfiga fndnewwflr kvklqetsql 661 dntlnykfiv scvfiilqii llllffggpn nikrrltkem klvgismcgl walatlinil 721 lelfs // LOCUS NP_012641 328 aa linear PLN 30-JUN-2025 DEFINITION putative lipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012641 VERSION NP_012641.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181765.2 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 328) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08892. On Apr 26, 2011 this sequence version replaced NP_012641.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..328 /product="putative lipase" /EC_number="3.1.1.3" /calculated_mol_wt="37074" Region 17..272 /region_name="Lipase_3" /note="Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; cd00519" /db_xref="CDD:238287" Site order(102..103,105..113) /site_type="active" /note="active site flap/lid [active]" /db_xref="CDD:238287" Site 179..183 /site_type="active" /note="nucleophilic elbow [active]" /db_xref="CDD:238287" CDS 1..328 /gene="LIH1" /locus_tag="YJR107W" /coded_by="NM_001181765.2:1..987" /note="Putative lipase" /db_xref="GeneID:853571" /db_xref="SGD:S000003868" ORIGIN 1 mpvvhcssnl pitpyiyerl vyfikassis scisdnlllv nktfndggcp phinfcndei 61 inptagqtvv elvlnakkge lgsgylavdh gkkvvilafr gsttrqdwfs dfeiypvnys 121 plcvkeyrkl ieegkirece gckmhrgflr ftetlgmdvf kkmesilesf peyrivvtgh 181 slgaalasla gielkirgfd plvltfatpk ifnsemkqwv delfetdaie kesilkdeiq 241 frkgyfrvvh tgdyipmvpp fyhpaglemf inkvglpqna edieyrgknn rltlkdgfre 301 gmsglvedwl hvyehrayfi dvvgcsgl // LOCUS NP_001381966 78 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR107C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381966 VERSION NP_001381966.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395036.1 REFERENCE 1 (residues 1 to 78) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 78) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 78) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 78) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54807. Method: conceptual translation. FEATURES Location/Qualifiers source 1..78 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..78 /product="uncharacterized protein" /calculated_mol_wt="8824" Region 1..76 /region_name="DUF5137" /note="Protein of unknown function (DUF5137); pfam17220" /db_xref="CDD:375058" CDS 1..78 /locus_tag="YJR107C-A" /coded_by="NM_001395036.1:1..237" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:26554900]" /note="hypothetical protein; encodes new type of domain, which ab initio modeling suggests is predominantly alpha-helical; nonessential for growth, deletion increases sensitivity to osmostress; expressed at moderate to high abundance; ORF also present in strains EC1118, YJM789, RM11-1a, and AWRI1631; Gln24 in S288C reference is substituted with Arg in wine strain EC1118; predicted S-palmitoylation site on Cys2, suggesting membrane association; transcript previously mischaracterized as SUT646" /db_xref="GeneID:65052910" /db_xref="SGD:S000303810" ORIGIN 1 mcddsydave eyyfnksvag isgqenwnkq latqvysrsl qpeilptlkp lscnkerana 61 gkrvseeeqi ngkrkrkd // LOCUS NP_012642 123 aa linear PLN 30-JUN-2025 DEFINITION Abm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012642 VERSION NP_012642.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181766.1 REFERENCE 1 (residues 1 to 123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 123) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08893. Method: conceptual translation. FEATURES Location/Qualifiers source 1..123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..123 /product="Abm1p" /calculated_mol_wt="14073" CDS 1..123 /gene="ABM1" /locus_tag="YJR108W" /coded_by="NM_001181766.1:1..372" /experiment="EXISTENCE:mutant phenotype:GO:0000226 microtubule cytoskeleton organization [PMID:10628851]" /note="hypothetical protein; required for normal microtubule organization" /db_xref="GeneID:853572" /db_xref="SGD:S000003869" ORIGIN 1 mswrysiltv dgsfkifipw eifltwnfls aawlnstesn tyihystcwg tsdytlnisv 61 ieatteklvd trllttlena tawinsnsid ededdmphat nvadrldgls lskrvysich 121 yef // LOCUS NP_012643 1118 aa linear PLN 30-JUN-2025 DEFINITION carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012643 VERSION NP_012643.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181767.3 REFERENCE 1 (residues 1 to 1118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1118) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08894. On Jul 30, 2012 this sequence version replaced NP_012643.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1118 /product="carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2" /EC_number="6.3.5.5" /EC_number="6.3.4.16" /calculated_mol_wt="123785" Region 23..1084 /region_name="CPSaseII_lrg" /note="carbamoyl-phosphate synthase, large subunit; TIGR01369" /db_xref="CDD:273581" CDS 1..1118 /gene="CPA2" /locus_tag="YJR109C" /coded_by="NM_001181767.3:1..3357" /experiment="EXISTENCE:direct assay:GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [PMID:8626695]" /experiment="EXISTENCE:direct assay:GO:0005951 carbamoyl-phosphate synthase complex [PMID:206535]" /experiment="EXISTENCE:mutant phenotype:GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [PMID:6358221]" /experiment="EXISTENCE:mutant phenotype:GO:0006526 L-arginine biosynthetic process [PMID:8626695]" /note="Large subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor" /db_xref="GeneID:853573" /db_xref="SGD:S000003870" ORIGIN 1 mtsiytstep tnsafttedy kpqlvegvns vlvigsggls igqagefdys gsqaikalke 61 dnkftilvnp niatnqtshs ladkiyylpv tpeyityiie lerpdaillt fggqtglncg 121 valdesgvla kynvkvlgtp iktlitsedr dlfasalkdi nipiaesfac etvdealeaa 181 ervkypvivr sayalgglgs gfannasemk elaaqslsla pqilvekslk gwkeveyevv 241 rdrvgncitv cnmenfdplg vhtgdsmvfa psqtlsdeef hmlrsaaiki irhlgvigec 301 nvqyalqpdg ldyrvievna rlsrssalas katgyplayt aakiglgytl pelpnpitkt 361 tvanfepsld yivakipkwd lskfqyvdrs igssmksvge vmaigrnyee afqkalrqvd 421 psllgfqgst efgdqldeal rtptdrrvla igqaliheny tvervnelsk idkwflykcm 481 nivniykele svkslsdlsk dllqrakklg fsdkqiavti nkhastnine leirslrktl 541 giipfvkrid tlaaefpaqt nylyttynat kndvefneng mlvlgsgvyr igssvefdwc 601 avntaktlrd qgkktiminy npetvstdfd evdrlyfeel syervmdiye leqsegciis 661 vggqlpqnia lklydngcni mgtnpndidr aenrhkfssi ldsidvdqpe wseltsveea 721 klfaskvnyp vlirpsyvls gaamsvvnne eelkakltla sdvspdhpvv mskfiegaqe 781 idvdavayng nvlvhaiseh venagvhsgd aslvlppqhl sddvkialkd iadkvakawk 841 itgpfnmqii kdgehtlkvi ecnirasrsf pfvskvlgvn fieiavkafl ggdivpkpvd 901 lmlnkkydyv atkvpqfsft rlagadpflg vemastgeva sfgrdliesy wtaiqstmnf 961 hvplppsgil fggdtsreyl gqvasivati gyriyttnet tktylqehik eknakvslik 1021 fpkndkrklr elfqeydika vfnlaskrae stddvdyimr rnaidfaipl fnepqtallf 1081 akclkakiae kikileshdv ivppevrswd efigfkay // LOCUS NP_012644 688 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol-3-phosphatase YMR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012644 VERSION NP_012644.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181768.1 REFERENCE 1 (residues 1 to 688) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 688) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 688) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 688) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08895. Method: conceptual translation. FEATURES Location/Qualifiers source 1..688 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..688 /product="phosphatidylinositol-3-phosphatase YMR1" /EC_number="3.1.3.64" /calculated_mol_wt="80021" Region 1..>44 /region_name="PH-like" /note="Pleckstrin homology-like domain; cl17171" /db_xref="CDD:473070" Region 152..570 /region_name="Myotub-related" /note="Myotubularin-like phosphatase domain; pfam06602" /db_xref="CDD:461958" CDS 1..688 /gene="YMR1" /locus_tag="YJR110W" /coded_by="NM_001181768.1:1..2067" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0046856 phosphatidylinositol dephosphorylation [PMID:15169871]" /experiment="EXISTENCE:mutant phenotype:GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity [PMID:15169871]" /experiment="EXISTENCE:mutant phenotype:GO:0046856 phosphatidylinositol dephosphorylation [PMID:15169871]" /note="Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family" /db_xref="GeneID:853574" /db_xref="SGD:S000003871" ORIGIN 1 meyikiakvs nvvlhrrgta tqgtlhltth hlifespqls tefwfpypli ygvhknpgst 61 llskltstnq iqlegtdsqn yklyqgkdlw sfvnikvigk dyavfsldfg gdlhlqarkv 121 ydsilnltvl snitqlyafi yisnnlerkl pspdswdiyd pikefrrqgl dskdetcpwr 181 lstvnehyef cptypsklfv prstsdillk haskfrsqkr ipvltyhhka tdcnilrssq 241 plpglinqrs iqdeklvwes fnsfcnkdir rtkhvivdar prtnalaqma lgggtenmdn 301 ynffladnnm gvdkslklpt vtrlflgidn ihivsntaay mtevicqggd lnlpleqnli 361 rsqkfsnwlk lntlilksvd mllksiifnh snvlvhcsdg wdrtsqvvsl leicldpfyr 421 tfegfmilve kdwcsfghrf lersghlnsd irfhdntmhs nfndvdtngd dldigvntqd 481 dyaeddegge detnlinlsr iskkfnenfk lnkkslkfvs pvfqqfldcv yqlltqnpdl 541 fefnerflrr lvyhlyscqy gtflsnseke kfqqnlpnkt ksvwdyfrsr rkqfinpnfi 601 qrkrsgmneh dqnleeeekv ewispdlkkv qwwwqlygrk dsemndelrh krdsvpisvd 661 kkskehsnsd ggkglnlsif gfdmfnrk // LOCUS NP_012645 283 aa linear PLN 30-JUN-2025 DEFINITION Pxp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012645 VERSION NP_012645.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181769.1 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 283) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08896. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..283 /product="Pxp2p" /calculated_mol_wt="32077" Region 214..282 /region_name="CMD" /note="Carboxymuconolactone decarboxylase family; pfam02627" /db_xref="CDD:460628" CDS 1..283 /gene="PXP2" /locus_tag="YJR111C" /coded_by="NM_001181769.1:1..852" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27392156]" /note="Peroxisomal matrix protein with naturally active promoter; well-conserved in fungi; localized to peroxisomes under physiological growth conditions; levels of some amino acids are altered upon both knockout and overexpression, suggesting potential involvement of Pxp2p in amino acid metabolism or related cellular metabolic processes (needs further study); GFP-fusion protein displays inherent dual localization with large proportion localizing to cytosol" /db_xref="GeneID:853575" /db_xref="SGD:S000003872" ORIGIN 1 mnqilnaqrl iqlsqfhpkl kniwylvaaa tfsvcnepqe ipklyhyaml lsndnahmyr 61 ftlasqtidl lrselpmrkt linenyqqpt ffqkqltakf revilktgpl aglpraingl 121 tmlkettpdi lvphldpidp weaamgnssp lsetsmrrkh dktiqerdht iqnglrhwns 181 iynkvstrvv nnlnssypdl wyytlvhvyg plfafdeils aqetslviia slvpqdvnpq 241 lrghlkgaln igcdketvea vrglailisq wcgvswksgv vkl // LOCUS NP_012646 201 aa linear PLN 30-JUN-2025 DEFINITION MIND complex subunit NNF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012646 VERSION NP_012646.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181770.3 REFERENCE 1 (residues 1 to 201) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 201) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 201) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 201) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08897. On Jul 30, 2012 this sequence version replaced NP_012646.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..201 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..201 /product="MIND complex subunit NNF1" /calculated_mol_wt="23508" Region 49..155 /region_name="Nnf1" /note="pfam03980" /db_xref="CDD:461118" CDS 1..201 /gene="NNF1" /locus_tag="YJR112W" /coded_by="NM_001181770.3:1..606" /experiment="EXISTENCE:direct assay:GO:0000444 MIS12/MIND type complex [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:14657030]" /experiment="EXISTENCE:direct assay:GO:0007059 chromosome segregation [PMID:12455957]" /note="Essential component of the outer kinetochore MIND complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for kinetochore bi-orientation and accurate chromosome segregation; complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; homologous to metazoan CENP-H proteins" /db_xref="GeneID:853576" /db_xref="SGD:S000003873" ORIGIN 1 mvnshgiryi rlkqvfnral dqsisklqsw dkvsscfpqy vnskqgainv ancqrqltef 61 wtelcqrefk eimeernveq klneldelil eakerytdrd qdevnkgpai delsskelve 121 chlysqrmha iheiderlak vnemndqlaq elkdletqve vekneigkmy deylgshtdq 181 panvllvqsl ndmvlelken y // LOCUS NP_878107 109 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR112W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878107 VERSION NP_878107.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184523.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 109) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08898. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..109 /product="uncharacterized protein" /calculated_mol_wt="12349" Region <22..105 /region_name="VanZ" /note="VanZ-like family protein (function unknown) [Function unknown]; cl42358" /db_xref="CDD:478153" CDS 1..109 /locus_tag="YJR112W-A" /coded_by="NM_001184523.1:1..330" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; identified based on homology to Ashbya gossypii" /db_xref="GeneID:1466470" /db_xref="SGD:S000028513" ORIGIN 1 mvqlrrtitt nkvfqaitst ndkvahfvvf mweswlfvkm faedivtfrk lqankyvlgv 61 licslcasvt sefaqsvvsr gqrvfdvkdi icnfwgsllg vgiafyqdr // LOCUS NP_012647 247 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS7m RSM7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012647 VERSION NP_012647.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181771.1 REFERENCE 1 (residues 1 to 247) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 247) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 247) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 247) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08899. Method: conceptual translation. FEATURES Location/Qualifiers source 1..247 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..247 /product="mitochondrial 37S ribosomal protein uS7m RSM7" /calculated_mol_wt="27685" Region 82..241 /region_name="uS7_Mitochondria_Fungi" /note="Fungal Mitochondrial homolog of Ribosomal Protein S7; cd14868" /db_xref="CDD:271247" Site order(119..121,125..129,132..133,167,177,186..187,190,194, 201,207..208,211) /site_type="other" /note="rRNA binding site [nucleotide binding]" /db_xref="CDD:271247" Site order(128,131..132,135,241) /site_type="other" /note="S11 interface [polypeptide binding]" /db_xref="CDD:271247" Site order(128,131..132,135) /site_type="other" /note="S9 interface [polypeptide binding]" /db_xref="CDD:271247" CDS 1..247 /gene="RSM7" /locus_tag="YJR113C" /gene_synonym="uS7m" /coded_by="NM_001181771.1:1..744" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S7 ribosomal protein" /db_xref="GeneID:853578" /db_xref="SGD:S000003874" ORIGIN 1 mlhcarryml vrprllwqsg tcvarfqssv rtpasepsae kgvdewleai nelreefsak 61 eylpetslap pgqskvdllq gsqagskikp taeqlaqwea lksvpipprk natldhitnm 121 imrhgkkeka qtilsralyl vycqtrqdpi qaleksldel aplmmtktfn tgvakasvip 181 vplnkrqrnr iawnwivqsa nqrvssdfav rlgeeltaia kgtssafekr dqihktaiah 241 rayiqlk // LOCUS NP_012649 169 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR115W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012649 VERSION NP_012649.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181773.3 REFERENCE 1 (residues 1 to 169) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 169) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 169) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 169) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08900. On Jul 30, 2012 this sequence version replaced NP_012649.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..169 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..169 /product="uncharacterized protein" /calculated_mol_wt="18918" CDS 1..169 /locus_tag="YJR115W" /coded_by="NM_001181773.3:1..510" /note="hypothetical protein; YJR115W has a paralog, ECM13, that arose from the whole genome duplication" /db_xref="GeneID:853579" /db_xref="SGD:S000003876" ORIGIN 1 mftntrtili ynskvmntht hththththi yiytgdqvsv rgrllslkff kvlklffpsp 61 tslatshppl ssmspymtip qqylyiskir sklsqcaltr hhhreldlrk mvghanmldr 121 ildeideids evvlcdaadg sstaeahsas passdssplt nnirpisim // LOCUS NP_012650 279 aa linear PLN 30-JUN-2025 DEFINITION Tda4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012650 VERSION NP_012650.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181774.1 REFERENCE 1 (residues 1 to 279) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 279) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 279) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 279) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08901. Method: conceptual translation. FEATURES Location/Qualifiers source 1..279 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..279 /product="Tda4p" /calculated_mol_wt="31880" Region 72..271 /region_name="TLC" /note="TRAM, LAG1 and CLN8 homology domains; smart00724" /db_xref="CDD:214789" CDS 1..279 /gene="TDA4" /locus_tag="YJR116W" /coded_by="NM_001181774.1:1..840" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Protein distantly similar to ceramide synthases, Lag1p and Lac1p; null mutant is sensitive to expression of the top1-T722A allele; mutation confers sensitivity to copper" /db_xref="GeneID:853580" /db_xref="SGD:S000003877" ORIGIN 1 mnanstttai gltspfekls ffphssnlil ahlheiifsf vfyqlafsvv apflnkvvfr 61 khyttirdpl lkidfnvhtv smiqavvsnt vllptlttpm hynvvtytds yssmvsslsa 121 gyfiwdltmc vryfklygle ftghaigsvy vmllslrpfc qpwigrfliy eastpfvnin 181 wfimqcnaks knsiplwfnv vnglllmtvf fvvricwgsi asallfrqmw kvrdelpkfs 241 avtmmslnif mnllnvlwfk kmiriakkla kpaptskld // LOCUS NP_012651 453 aa linear PLN 30-JUN-2025 DEFINITION zinc metalloprotease [Saccharomyces cerevisiae S288C]. ACCESSION NP_012651 VERSION NP_012651.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181775.1 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 453) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08902. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..453 /product="zinc metalloprotease" /EC_number="3.4.24.84" /calculated_mol_wt="52193" Region 17..446 /region_name="M48A_Zmpste24p_like" /note="Peptidase M48 subfamily A, a type 1 CaaX endopeptidase; cd07343" /db_xref="CDD:320702" Site order(297..298,301,390,394,434) /site_type="active" /db_xref="CDD:320702" Site order(297,301,390,434) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:320702" CDS 1..453 /gene="STE24" /locus_tag="YJR117W" /gene_synonym="AFC1; PIO2" /coded_by="NM_001181775.1:1..1362" /experiment="EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:11581258|PMID:27129777]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11581258]" /experiment="EXISTENCE:direct assay:GO:0016485 protein processing [PMID:27129777]" /experiment="EXISTENCE:direct assay:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:11581258]" /experiment="EXISTENCE:genetic interaction:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:26771486]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:26771486]" /experiment="EXISTENCE:genetic interaction:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:10825201|PMID:9065405|PMID:11581258]" /experiment="EXISTENCE:genetic interaction:GO:0071586 CAAX-box protein processing [PMID:9065405]" /experiment="EXISTENCE:mutant phenotype:GO:0005637 nuclear inner membrane [PMID:18923140]" /experiment="EXISTENCE:mutant phenotype:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:26771486]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:26771486]" /experiment="EXISTENCE:mutant phenotype:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:10825201|PMID:9065405]" /experiment="EXISTENCE:mutant phenotype:GO:0071586 CAAX-box protein processing [PMID:9065405]" /experiment="EXISTENCE:mutant phenotype:GO:0120236 negative regulation of post-translational protein targeting to membrane, translocation [PMID:32513868]" /note="Highly conserved zinc metalloprotease; component of the ER quality control mechanism that removes faulty proteins clogging translocation channels; inhibits SRP-independent translocation into the ER; has two roles in a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; cleaves isoprenylated and non-prenylated oligopeptides; human homolog ZMPSTE24 implicated in mandibuloacral dysplasia (MAD), and complements the null mutant" /db_xref="GeneID:853581" /db_xref="SGD:S000003878" ORIGIN 1 mfdlktildh pnipwkliis gfsiaqfsfe syltyrqyqk lsetklppvl edeiddetfh 61 ksrnysraka kfsifgdvyn laqklvfiky dlfpkiwhma vsllnavlpv rfhmvstvaq 121 slcflgllss lstlvdlpls yyshfvleek fgfnkltvql witdmikslt layaiggpil 181 ylflkifdkf ptdflwyimv flfvvqilam tiipvfimpm fnkftpledg elkksiesla 241 drvgfpldki fvidgskrss hsnayftglp ftskrivlfd tlvnsnstde itavlaheig 301 hwqknhivnm vifsqlhtfl ifslftsiyr ntsfyntfgf flekstgsfv dpvitkefpi 361 iigfmlfndl ltplecamqf vmslisrthe yqadayakkl gykqnlcral idlqiknlst 421 mnvdplyssy hyshptlaer ltaldyvsek kkn // LOCUS NP_012652 203 aa linear PLN 30-JUN-2025 DEFINITION Ilm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012652 VERSION NP_012652.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181776.3 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 203) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08903. On Jul 30, 2012 this sequence version replaced NP_012652.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..203 /product="Ilm1p" /calculated_mol_wt="23514" Region 17..141 /region_name="Ilm1" /note="Increased loss of mitochondrial DNA protein 1; pfam10311" /db_xref="CDD:431212" CDS 1..203 /gene="ILM1" /locus_tag="YJR118C" /coded_by="NM_001181776.3:1..612" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:10628851]" /note="hypothetical protein; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth" /db_xref="GeneID:853582" /db_xref="SGD:S000003879" ORIGIN 1 maqalnstni affrvaflft iaffclknvn silqntyfiv ltqamnlpql tlsrysgqlg 61 lfallftlng vhdlipllen nvkyfqsvvp vrlliffilt sisylwesnf yvhnnsvfiy 121 cfaevwinfl lynaireekn eefkrlnqfm vndedieepq pftvktette iieiindeen 181 ddedgkdndd nnekgnddsd akk // LOCUS NP_012653 728 aa linear PLN 30-JUN-2025 DEFINITION histone demethylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012653 VERSION NP_012653.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181777.1 REFERENCE 1 (residues 1 to 728) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 728) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 728) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 728) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 728) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 728) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 728) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08904. Method: conceptual translation. FEATURES Location/Qualifiers source 1..728 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..728 /product="histone demethylase" /EC_number="1.14.11.67" /calculated_mol_wt="84853" Region 3..46 /region_name="JmjN" /note="Small domain found in the jumonji family of transcription factors; smart00545" /db_xref="CDD:128818" Region 237..282 /region_name="PHD_BAZ1A_like" /note="PHD finger found in bromodomain adjacent to zinc finger domain protein BAZ1A and BAZ1B; cd15544" /db_xref="CDD:277019" Site order(237,249..253,257,277) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:277019" Region 260..>320 /region_name="BAH" /note="or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in...; cl02608" /db_xref="CDD:470629" Region 414..532 /region_name="JmjC" /note="JmjC domain, hydroxylase; pfam02373" /db_xref="CDD:396791" CDS 1..728 /gene="JHD2" /locus_tag="YJR119C" /gene_synonym="KDM5" /coded_by="NM_001181777.1:1..2187" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032453 histone H3K4 demethylase activity [PMID:17310254]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27325136]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:25248920]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:25248920]" /experiment="EXISTENCE:mutant phenotype:GO:0032453 histone H3K4 demethylase activity [PMID:17369256|PMID:17310254]" /experiment="EXISTENCE:mutant phenotype:GO:0043934 sporulation [PMID:23123093]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27325136|PMID:23123093]" /experiment="EXISTENCE:mutant phenotype:GO:0060623 regulation of chromosome condensation [PMID:25248920]" /experiment="EXISTENCE:mutant phenotype:GO:0071041 antisense RNA transcript catabolic process [PMID:23123093]" /experiment="EXISTENCE:mutant phenotype:GO:1902275 regulation of chromatin organization [PMID:27325136]" /experiment="EXISTENCE:mutant phenotype:GO:1903047 mitotic cell cycle process [PMID:25248920]" /note="JmjC domain family histone demethylase; promotes global demethylation of H3K4 and represses noncoding intergenic transcription during sporulation; removes methyl groups added by Set1p; phosphorylation by Tpk2p during glycolysis inhibits activity, nuclear localization, chromatin binding and promotes Not4p Ub-mediated degradation; negatively regulated by H3K14 acetylation; regulates sporulation timing by extending period of active transcription; regulates rDNA silencing; human homolog is JARID1C" /db_xref="GeneID:853583" /db_xref="SGD:S000003880" ORIGIN 1 meeipalypt eqefknpidy lsnphikrlg vrygmvkvvp pngfcpplsi dmenftfqpr 61 iqnlenldlk nrcrlffmkq lnnfkrsvkd psklilrepy tiveysdsth aseilkkkvy 121 fydvfselik dnrtltdttq sfrrklkfrd isqlrgdisl wrtiskkfnv pigllkeife 181 kyiasyyifl hslnenvhta lhadqypksl lsddeddfdl gpdsnsgsdf eeddddaciv 241 crktndpkrt ilcdscdkpf hiyclspple rvpsgdwicn tcivgngyyg ftqdthdysl 301 pefqeyckrq nsrllparkl sideleemfw slvtknrrss lttvkygadi hnelpgqitg 361 fptrefipkn ingdelidyl kycdhpmnlt nlpmahnsll plfkrnisgm tipwiyigsl 421 fstfcwhmed qytlsanyqh egdpkvwysi pesgctkfnd llndmspdlf ikqpdllhql 481 vtlispydpn fkksgipvyk avqkpneyii tfpkcyhagf ntgynfneav nftidfwlpy 541 gfgaitdykl tqkacvfdmf dlminvldky nkdtllfnda fvrqcyssli vfyntelkri 601 rkiqaivprt tllevhtdpn dedeeydifc sqckticsia fvlrknnyds irtykrhkkn 661 hlsirqwnel sttdskvsil ctqdylksiq nlnnsdgeep yiddelyftk slkdidslik 721 qvgvkldr // LOCUS NP_012654 116 aa linear PLN 30-JUN-2025 DEFINITION Dmo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012654 VERSION NP_012654.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181778.1 REFERENCE 1 (residues 1 to 116) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 116) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 116) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 116) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08905. Method: conceptual translation. FEATURES Location/Qualifiers source 1..116 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..116 /product="Dmo1p" /calculated_mol_wt="13279" CDS 1..116 /gene="DMO1" /locus_tag="YJR120W" /coded_by="NM_001181778.1:1..351" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:10628851]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:16251356]" /experiment="EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:10628851]" /note="hypothetical protein; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p" /db_xref="GeneID:853584" /db_xref="SGD:S000003881" ORIGIN 1 mrwdviilya isrpyatrrt gshthprdsr yiaanqrrpp sacrvgpspa kqrkdipife 61 lldttlikna lfaltsflyy rtniltcpfl nflylsrtgq ldkfckdqtv tqilat // LOCUS NP_012655 511 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_012655 VERSION NP_012655.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181779.3 REFERENCE 1 (residues 1 to 511) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 511) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 511) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 511) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08906. On Jul 30, 2012 this sequence version replaced NP_012655.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..511 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..511 /product="F1F0 ATP synthase subunit beta" /EC_number="7.1.2.2" /calculated_mol_wt="54663" Region 39..500 /region_name="AtpD" /note="FoF1-type ATP synthase, beta subunit [Energy production and conversion]; COG0055" /db_xref="CDD:439825" CDS 1..511 /gene="ATP2" /locus_tag="YJR121W" /coded_by="NM_001181779.3:1..1536" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:18722382|PMID:15294286]" /experiment="EXISTENCE:direct assay:GO:0045259 proton-transporting ATP synthase complex [PMID:15294286|PMID:17082766]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:2529856|PMID:6225776]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:6225776]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:6225776]" /experiment="EXISTENCE:mutant phenotype:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:2529856]" /note="Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated" /db_xref="GeneID:853585" /db_xref="SGD:S000003882" ORIGIN 1 mvlprlytat sraafkaakq sapllstswk rcmasaaqst pitgkvtavi gaivdvhfeq 61 selpailnal eiktpqgklv levaqhlgen tvrtiamdgt eglvrgekvl dtggpisvpv 121 gretlgriin vigepiderg piksklrkpi hadppsfaeq stsaeiletg ikvvdllapy 181 arggkiglfg gagvgktvfi qelinniaka hggfsvftgv gertregndl yremketgvi 241 nlegeskval vfgqmneppg ararvaltgl tiaeyfrdee gqdvllfidn ifrftqagse 301 vsallgrips avgyqptlat dmgllqerit ttkkgsvtsv qavyvpaddl tdpapattfa 361 hldattvlsr giselgiypa vdpldsksrl ldaavvgqeh ydvaskvqet lqtykslqdi 421 iailgmdels eqdkltvera rkiqrflsqp favaevftgi pgklvrlkdt vasfkavleg 481 kydnipehaf ymvggiedvv akaeklaaea n // LOCUS NP_012656 497 aa linear PLN 30-JUN-2025 DEFINITION Iba57p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012656 VERSION NP_012656.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181780.1 REFERENCE 1 (residues 1 to 497) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 497) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 497) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 497) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08907. Method: conceptual translation. FEATURES Location/Qualifiers source 1..497 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..497 /product="Iba57p" /calculated_mol_wt="56924" Region 50..>383 /region_name="YgfZ" /note="Folate-binding protein YgfZ, synthesis and repair of Fe-S clusters [Posttranslational modification, protein turnover, chaperones]; COG0354" /db_xref="CDD:440123" Region 320..382 /region_name="ygfZ_signature" /note="folate-binding protein YgfZ; TIGR03317" /db_xref="CDD:274518" CDS 1..497 /gene="IBA57" /locus_tag="YJR122W" /gene_synonym="CAF17" /coded_by="NM_001181780.1:1..1494" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:18086897]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:29343425|PMID:18086897]" /note="Protein involved in incorporating iron-sulfur clusters into proteins; mitochondrial matrix protein; involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system" /db_xref="GeneID:853586" /db_xref="SGD:S000003883" ORIGIN 1 mfisrrcrik gftlknllwf rssstrfvst espdasaitk pdgifnysll enrtyirirg 61 pdtvkflngl vtskllphfi kknlttveen evpteegttk vdpiipvpef darlgnwgly 121 nekgiqgpyi srfglysafl ngkgklitdt iiyptpvtvs eqisnypeyl lelhgnvvdk 181 ilhvlqthkl ankikfekid hsslktwdve vqfpnlpkdi enpwfdnlld pmalpknsid 241 annfavnvln slfnsdpril giyverrtes msrhystfpq sfrvvtseqv ddlsklfnfn 301 vfdfpfqvnk kasvqvreir fqkglidste dyisetllpl elnfdffpnt istnkgcyvg 361 qeltartyat gilrkrlvpv kldnyqlldt dperkyaefh idnvveksla eneptlnpft 421 nkppertkrk qrpagllisn eglygvallr tehfsaafss depvefyitt tkgenikitp 481 qkpfwfsdwk nnngphk // LOCUS NP_012657 225 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS7 RPS5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012657 VERSION NP_012657.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181781.1 REFERENCE 1 (residues 1 to 225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 225) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08908. Method: conceptual translation. FEATURES Location/Qualifiers source 1..225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..225 /product="40S ribosomal protein uS7 RPS5" /calculated_mol_wt="24908" Region 41..225 /region_name="uS7_Eukaryote" /note="Eukaryota homolog of Ribosomal Protein S7; cd14867" /db_xref="CDD:271246" Site order(41,68..70,72..75,108,112) /site_type="other" /note="S9 interface [polypeptide binding]" /db_xref="CDD:271246" Site order(72,74,78..81,84,92,95,97..101,105..109,112,152..154, 156,166,173,180,183,189..190) /site_type="other" /note="rRNA binding site [nucleotide binding]" /db_xref="CDD:271246" Site order(116,119..120,123,189,191..192) /site_type="other" /note="S25 interface [polypeptide binding]" /db_xref="CDD:271246" Site order(151,154,156,225) /site_type="other" /note="S11 interface [polypeptide binding]" /db_xref="CDD:271246" CDS 1..225 /gene="RPS5" /locus_tag="YJR123W" /coded_by="NM_001181781.1:1..678" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480|PMID:385049]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:20419091]" /note="Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7" /db_xref="GeneID:853587" /db_xref="SGD:S000003884" ORIGIN 1 msdteapvev qedfevveef tpvvlatpip eevqqaqtei klfnkwsfee vevkdaslvd 61 yvqvrqpifv ahtagryank rfrkaqcpii erltnslmmn grnngkklka vriikhtldi 121 invltdqnpi qvvvdaitnt gpredttrvg gggaarrqav dvsplrrvnq aialltigar 181 eaafrnikti aetlaeelin aakgsstsya ikkkdelerv aksnr // LOCUS NP_012658 448 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR124C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012658 VERSION NP_012658.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181782.3 REFERENCE 1 (residues 1 to 448) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 448) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 448) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 448) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08909. On Jul 30, 2012 this sequence version replaced NP_012658.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..448 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..448 /product="uncharacterized protein" /calculated_mol_wt="49533" Region 19..431 /region_name="MFS" /note="Major Facilitator Superfamily; cl28910" /db_xref="CDD:475125" Site order(26..27,30..31,34,66,121..122,124..126,129,149, 152..153,156,265,268..269,272..274,277,306,310,360..361, 365,369,385,388..389,392..393,396) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340883" CDS 1..448 /locus_tag="YJR124C" /coded_by="NM_001181782.3:1..1347" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347|PMID:26928762]" /note="hypothetical protein; expression induced under calcium shortage" /db_xref="GeneID:853588" /db_xref="SGD:S000003885" ORIGIN 1 mapeifvkfk casrdikllw asvflrllsy gltnqvltlf lnainmtedk iglfmsltla 61 gdvicsyilt wyadswgrrr vlvygcamml lsglvfsfse nftlllvfai fgvispssde 121 vgpfksieea miahlsphna rpeiyaihal vgtigsalga iicgifvdll krtglaatdl 181 qcyklvflly affafckmvi mlllsdatel dghyehtdcn eetaepldvn detaplmrqa 241 thpeersnkl sketvsvlmk llvifmvdsl gsgfmtsgwm vyyyskqflm gslalgtlff 301 itqlvmasst ipssiiarcf gpvratllvq ipsgifsili pmaknylpls ilflnlhfat 361 tamdvtprqi lltniikprd ltkvmgvvni gktfarcvgp iftgilannn ylwlcyiisg 421 slvitadlil acmflgvdak ikkqmnrh // LOCUS NP_012659 408 aa linear PLN 30-JUN-2025 DEFINITION Ent3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012659 VERSION NP_012659.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181783.1 REFERENCE 1 (residues 1 to 408) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 408) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 408) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 408) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08910. Method: conceptual translation. FEATURES Location/Qualifiers source 1..408 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..408 /product="Ent3p" /calculated_mol_wt="44960" Region 32..152 /region_name="ENTH_Ent3" /note="Epsin N-Terminal Homology (ENTH) domain of Yeast Ent3 and similar proteins; cd16992" /db_xref="CDD:340789" Site order(37,41..42,75,82,86) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:340789" Site order(60..62,102..104,150..151) /site_type="other" /note="putative SNARE interaction site [polypeptide binding]" /db_xref="CDD:340789" CDS 1..408 /gene="ENT3" /locus_tag="YJR125C" /coded_by="NM_001181783.1:1..1227" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:12967568]" /experiment="EXISTENCE:direct assay:GO:0030125 clathrin vesicle coat [PMID:12483220]" /experiment="EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:12967568]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:14630930]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:14630930]" /experiment="EXISTENCE:genetic interaction:GO:0034498 early endosome to Golgi transport [PMID:20658963]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:12483220]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:12967568]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:15107463]" /experiment="EXISTENCE:mutant phenotype:GO:0071985 multivesicular body sorting pathway [PMID:12967568]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12483220]" /note="Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p" /db_xref="GeneID:853589" /db_xref="SGD:S000003886" ORIGIN 1 msledtlanm slydakkyfr kaqnvvfnyt emegkvreat nnepwgasst lmdqisqgty 61 nfrereeils mifrrfteka gsewrqiyka lqlldylikh gserfiddtr nsinlirile 121 tfhyidsqgr dqginvrtrv kaliellsdd nkiraerkka retakkykgv aggsasadgs 181 lnskagftst kvhgisvsad fdsdnedned gsfsqngynd nasratstpg qgkqepedfv 241 dffssesskp skeliqedek kadeeedddd efsefqsavp vtnpansfnl lntspiegmp 301 attssmpfyn ssttdqgkit paiaepkkvd pfsslfstak asaeapsapk asqakaaasn 361 pvsnsttals tdqddddefg emhggavqqe qntnnnhtss keidllsf // LOCUS NP_012660 811 aa linear PLN 30-JUN-2025 DEFINITION putative zinc metalloprotease [Saccharomyces cerevisiae S288C]. ACCESSION NP_012660 VERSION NP_012660.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181784.1 REFERENCE 1 (residues 1 to 811) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 811) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 811) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 811) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08911. Method: conceptual translation. FEATURES Location/Qualifiers source 1..811 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..811 /product="putative zinc metalloprotease" /calculated_mol_wt="91887" Region 135..>187 /region_name="Zinc_peptidase_like" /note="Zinc peptidases M18, M20, M28, and M42; cl14876" /db_xref="CDD:472712" Region 187..413 /region_name="PA_GCPII_like" /note="Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase...; cd02121" /db_xref="CDD:239036" Site order(234,326..328,330,337..340,343) /site_type="other" /note="apical/protease domain interface [polypeptide binding]" /db_xref="CDD:239036" Site order(279,330) /site_type="other" /note="substrate binding [chemical binding]" /db_xref="CDD:239036" Site order(346..347,349,351) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:239036" Region 419..649 /region_name="M28_PMSA_TfR_like" /note="M28 Zn-peptidase Transferrin Receptor-like family; cd03874" /db_xref="CDD:349871" Site order(436..437,439,484,486,505..506,508,510..513,647) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:349871" Region <725..799 /region_name="TFR_dimer" /note="Transferrin receptor-like dimerization domain; pfam04253" /db_xref="CDD:461238" CDS 1..811 /gene="VPS70" /locus_tag="YJR126C" /coded_by="NM_001181784.1:1..2436" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /note="hypothetical protein involved in vacuolar protein sorting; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum" /db_xref="GeneID:853590" /db_xref="SGD:S000003887" ORIGIN 1 mrmiqrerkr ekeegqlker tvvnmadpdd neaeatglqq ysgettrddn eesmndsftl 61 tsrnrgrsnt issivsgyei mkehmdkekf mylilaslll ymgfvaafap rtslsrdfrr 121 fhssrltnae vyriylnslq qenrakehvy kyagymsnga sdsstfkytl defldmgykp 181 kvekyypwig epvdtnvapl engkvvyeas miedrvkgdp asharkrqkg fhqyskngsv 241 taryvfcnyg sisdyklllk knidiedkih ivrsgkilpg lkvknaelyg assviiytdp 301 fddgkvteen gflhypygpa rnpsyirrds vnyfsdtpgd pttpgypskd sdtehmspvg 361 rvpripsvpm sardvqpile rlngrgfqig pgsnikdfgs ftgpsssidk vhlhneltyn 421 ikemssvevs ipgiftegei iigahrdsla sssagdansg sailleiarg mskllkhgwk 481 plrpiklisw dgersgllgs tdyaeahaai lrrralvyln ldnaisgtnf hckanpllqd 541 viyeaaklte fnghedwslf dhwkytsnat islldglssy tsfqyhlgvp aahfqfnand 601 tsgavyhsns vfdsptwlek ftnsdyklhn tmamfvgltt lmlsenelar fnthvylkki 661 ynwyiawhsn lssafpqdde vnslakrvld llkvatqeds iqfdqqngil ykecrealpv 721 wafykkiksy iklqrsnsks kqidqlfith rglkdrewmk ysllapskfe gsvgevlpgl 781 hegladidrn eviqwltill sqfsnvryll q // LOCUS NP_012661 1380 aa linear PLN 30-JUN-2025 DEFINITION Rsf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012661 VERSION NP_012661.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181785.3 REFERENCE 1 (residues 1 to 1380) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1380) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1380) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1380) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08912. On Jul 30, 2012 this sequence version replaced NP_012661.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1380 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1380 /product="Rsf2p" /calculated_mol_wt="154933" Region 153..173 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 165..190 /region_name="zf-H2C2_2" /note="Zinc-finger double domain; pfam13465" /db_xref="CDD:463886" Region 181..202 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 450..990 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" CDS 1..1380 /gene="RSF2" /locus_tag="YJR127C" /gene_synonym="ZMS1" /coded_by="NM_001181785.3:1..4143" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:16208474]" /note="Zinc-finger protein; involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions; RSF2 has a paralog, TDA9, that arose from the whole genome duplication; relocalizes from nucleus to cytoplasm upon DNA replication stress" /db_xref="GeneID:853592" /db_xref="SGD:S000003888" ORIGIN 1 mepfafgrga palciltaaa rinldnfvpc cwalfrlsff fpldpayirn enketrtswi 61 sieffffvkh clsqhtffsk tlapkrnfra kklkdigdtr idradkdfll vpepsmfvng 121 nqsnfakpag qgilpipkks riiktdkprp flcptctrgf vrqehlkrhq hshtrekpyl 181 cifcgrcfar rdlvlrhqqk lhaalvgtgd prrmtpapns tssfaskrrh svaaddptdl 241 hiikiagnke tilptpknla gktseelkea vvalaksnnv elpvsapvmn dkrektppsk 301 agslgfrefk fstkgvpvhs assdavidra ntpssmhktk rhasfsassa mtymsssnsp 361 hhsitnfelv edaphqvgfs tpqmtakqlm esvseldlpp ltldeppqai kfnlnlfnnd 421 psgqqqqqqq qqqnstssti vnsnngstva tpgvyllssg psltdlltmn sahagaggym 481 sshhspfdlg cfshdkptvs efnlpssfpn tipsnsttas nsysnlanqt yrqmsneqpl 541 mslspknppt tvsdssstin fnpgtnnlle psmepndkds nidpaaiddk wlsefinnsd 601 pkstfkinfn hfndigfiys ppssrssipn ksppnhsats lnhekaslsp rlnlslngst 661 dlpstpqnql kepsysdpis hsshkrrrds vmmdydlsnf fssrqldisk vlngteqnns 721 hvnddvltls fpgetdsnat qkqlpvltps dllspfsvps vsqvlftnel rsmmladnni 781 dsgafpttsq lndyvtyyke efhpffsfih lpsiipnmds yplllsismv galygfhsth 841 akvlanaast qirkslkvse knpettelwv iqtlvlltfy cifnkntavi kgmhgqltti 901 irllkasrln lpleslcqpp iesdhimeye nsphmfskir eqynapnqmn knyqyfvlaq 961 srirtchavl lisnlfsslv gadccfhsvd lkcgvpcyke elyqcrnsde wsdllcqyki 1021 tldskfslie lsngneayen clrflstgds ffygnarvsl stclsllisi hekiliernn 1081 arisnnntns nnielddiew kmtsrqridt mlkywenlyl knggiltpte nsmstinanp 1141 amrliipvyl fakmrrcldl ahviekiwlk dwsnmnkale evcydmgslr eateyalnmv 1201 dawtsfftyi kqgkrrifnt pvfattcmft avlviseymk cvedwargyn annpnsalld 1261 fsdrvlwlka erilrrlqmn lipkecdvlk sytdflrwqd kdaldlsaln eeqaqramdp 1321 ntdinetiql ivaaslsskc lylgvqilgd apiwpiilsf ahglqsraiy svtkkrntri // LOCUS NP_001335788 119 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR128W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335788 VERSION NP_001335788.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348848.1 REFERENCE 1 (residues 1 to 119) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 119) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 119) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 119) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80308. Method: conceptual translation. FEATURES Location/Qualifiers source 1..119 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..119 /product="uncharacterized protein" /calculated_mol_wt="13366" CDS 1..119 /locus_tag="YJR128W" /coded_by="NM_001348848.1:1..360" /note="hypothetical protein; conserved among S. cerevisiae strains; partially overlaps the verified ORF RSF2" /db_xref="GeneID:853591" /db_xref="SGD:S000003889" ORIGIN 1 mqgqagkrkt dgkvpsnteq ncpdlferpr lvcimqaplv qmrtvpsetg hfpkiislnr 61 scsrsyllsm phtqlpyplp ygefprcstv rrdhnfpctl ysapgvvhpr lcvfscmmi // LOCUS NP_012663 339 aa linear PLN 30-JUN-2025 DEFINITION protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012663 VERSION NP_012663.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181787.2 REFERENCE 1 (residues 1 to 339) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 339) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 339) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 339) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08913. On Apr 26, 2011 this sequence version replaced NP_012663.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..339 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..339 /product="protein-lysine N-methyltransferase" /calculated_mol_wt="38893" Region 137..286 /region_name="AdoMet_MTases" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl17173" /db_xref="CDD:473071" CDS 1..339 /gene="EFM3" /locus_tag="YJR129C" /coded_by="NM_001181787.2:1..1020" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016279 protein-lysine N-methyltransferase activity [PMID:25086354]" /experiment="EXISTENCE:direct assay:GO:0018023 peptidyl-lysine trimethylation [PMID:25086354]" /experiment="EXISTENCE:mutant phenotype:GO:0018023 peptidyl-lysine trimethylation [PMID:25231983|PMID:25086354]" /note="S-adenosylmethionine-dependent methyltransferase; seven-beta-strand lysine methyltransferase which trimethylates translation elongation factor EF2 (Eft1p and Eft2p) at lysine 509; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; ortholog of human gene FAM86A" /db_xref="GeneID:853593" /db_xref="SGD:S000003890" ORIGIN 1 mnedlfydrl hqrcpgkyll eeletsksnd vlhasrfvce melvqktnay ycktivkmll 61 dhewifakaf tivndgedei eiydylyeky ikllstgkpd pmmkdvvryr fdedvkikie 121 etpnlisaas ttgfrtweaa lymgdflihk plqelapvqg qddgkkklnv levgagtgiv 181 slvilqkyhe fvnkmyvtdg dsnlvetqlk rnfelnnevr enepdiklqr lwwgsdrvpe 241 didlvvgadv tydptilpdl ceclaeclal drcklcllsa tirsestvql fsqecnklgl 301 kctivtstey danneiramk alqfkpliap iriykitkq // LOCUS NP_012664 639 aa linear PLN 30-JUN-2025 DEFINITION cystathionine gamma-synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012664 VERSION NP_012664.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181788.1 REFERENCE 1 (residues 1 to 639) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 639) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 639) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 639) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08914. Method: conceptual translation. FEATURES Location/Qualifiers source 1..639 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..639 /product="cystathionine gamma-synthase" /EC_number="2.5.1.48" /calculated_mol_wt="72220" Region 290..636 /region_name="MetC" /note="Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; COG0626" /db_xref="CDD:440391" CDS 1..639 /gene="STR2" /locus_tag="YJR130C" /coded_by="NM_001181788.1:1..1920" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0003962 cystathionine gamma-synthase activity [PMID:10821189]" /experiment="EXISTENCE:mutant phenotype:GO:0006790 sulfur compound metabolic process [PMID:10821189]" /experiment="EXISTENCE:mutant phenotype:GO:0019346 transsulfuration [PMID:10821189]" /note="Cystathionine gamma-synthase, converts cysteine into cystathionine; STR2 has a paralog, YML082W, that arose from the whole genome duplication" /db_xref="GeneID:853594" /db_xref="SGD:S000003891" ORIGIN 1 misrtigesi ppntkhavsv clptweatvg yeegessiin slttgyprff ihksikklce 61 ilsakysmed eaclcfpsyk vanrcrefik vktglstkvr ilqlctpkpm nqeeklwrre 121 ckitvvfvdq eifpvmkqyw qhsgeivssr maeyilhelq vkdnlkkmet vdngkkfmte 181 denrvneeyi etrfgrnlnf laadkakyli rkriatkvve kidseglsdl fsfehynesn 241 gpfnvgsgea ldddqlnsdi paetitsmge sgsnstfent atddlkfhvn pntdvylfps 301 gmasiftahr lllnfdakrl srsssrqdkl igygppfkkt vmfgfpytdt lsilrkfnht 361 hflgqgdsts mnalknilhs geqilavfie apsnpllkmg dlqelkrlsd lysfyivvde 421 tvggfvnidv lpyadivcss ltkifsgdsn viagslvlnp rgkiyefark fmktedgyed 481 clwcedalcl ernsrdfver tikvntntdi llkrvllpqv gklfkkiyyp sltsedtkrn 541 ydsvmstkdg gygglfsltf fnieeakkff nnlelckgps lgtnftlacp yaiiahyqel 601 devaqygvet nlvrvsvgle nsdvlcnvfq raiekalge // LOCUS NP_012665 549 aa linear PLN 30-JUN-2025 DEFINITION mannosyl-oligosaccharide 1,2-alpha-mannosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012665 VERSION NP_012665.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181789.3 REFERENCE 1 (residues 1 to 549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 549) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08915. On Jul 30, 2012 this sequence version replaced NP_012665.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..549 /product="mannosyl-oligosaccharide 1,2-alpha-mannosidase" /EC_number="3.2.1.113" /calculated_mol_wt="62926" Region 45..532 /region_name="Glyco_hydro_47" /note="Glycosyl hydrolase family 47; pfam01532" /db_xref="CDD:460241" CDS 1..549 /gene="MNS1" /locus_tag="YJR131W" /coded_by="NM_001181789.3:1..1650" /experiment="EXISTENCE:direct assay:GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [PMID:8910350]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8864657]" /experiment="EXISTENCE:mutant phenotype:GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity [PMID:8439291|PMID:1714453]" /experiment="EXISTENCE:mutant phenotype:GO:0035977 protein deglycosylation involved in glycoprotein catabolic process [PMID:9732283]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:8905927]" /note="Alpha-1,2-mannosidase; involved in ER-associated protein degradation (ERAD); catalyzes the removal of one mannose residue from a glycosylated protein, converting the modification from Man9GlcNAc to Man8GlcNAc; catalyzes the last step in glycoprotein maturation in the ER and is critical for ER protein degradation" /db_xref="GeneID:853595" /db_xref="SGD:S000003892" ORIGIN 1 mknsvgisia tivaiiaaiy yvpwyehfer kspgagemrd riesmflesw rdyskhgwgy 61 dvygpiehts hnmprgnqpl gwiivdsvdt lmlmynsstl yksefeaeiq rsehwindvl 121 dfdidaevnv fettirmlgg llsayhlsdv levgnktvyl nkaidlgdrl alaflstqtg 181 ipyssinlhs gqavknhadg gasstaeftt lqmefkylay ltgnrtywel vervyeplyk 241 nndllntydg lvpiytfpdt gkfgastirf gsrgdsfyey llkqyllthe tlyydlyrks 301 megmkkhlla qskpsslwyi gereqglhgq lspkmdhlvc fmggllasgs teglsihear 361 rrpffslsle rksdwdlakg itdtcyqmyk qsssglapei vvfndgnikq dgwwrssvgd 421 ffvkpldrhn lqrpetvesi mfmyhlshdh kyrewgaeia tsffentcvd cndpklrrft 481 slsdcitlpt kksnnmesfw laetlkylyi lfldefdltk vvfnteahpf pvldeeilks 541 qslttgwsl // LOCUS NP_012666 1048 aa linear PLN 30-JUN-2025 DEFINITION Nmd5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012666 VERSION NP_012666.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181790.2 REFERENCE 1 (residues 1 to 1048) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1048) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1048) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1048) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1048) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1048) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1048) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08916. On Apr 26, 2011 this sequence version replaced NP_012666.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1048 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1048 /product="Nmd5p" /calculated_mol_wt="119837" Region 2..1048 /region_name="SXM1" /note="Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]; COG5656" /db_xref="CDD:227943" CDS 1..1048 /gene="NMD5" /locus_tag="YJR132W" /gene_synonym="KAP119" /coded_by="NM_001181790.2:1..3147" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9852143]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:9852143]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:9852143]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:9755161]" /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:9755161]" /note="Karyopherin; a carrier protein involved in nuclear import of proteins; importin beta homolog" /db_xref="GeneID:853596" /db_xref="SGD:S000003893" ORIGIN 1 mditellqcf actldhnaav rtnaethlkn askvpgflga cldiiaadev peniklsasl 61 yfknkitygw sagarqgsne lldshvdpde kpvvkdmlik tmvsvsktsp rcirvlksal 121 tviisedyps kkwgnllpns lellanedit vtyvgllcla eifrtyrwkn nderqdleel 181 ilnyfpalln yganvlfqdg kymnneqige lvkliikiyk fvsyhdlpft lqrsesftpw 241 acffvsiiqq plpqevlais dievrsknpw vkckkwalan lyrlfqryas tsltrkfqyd 301 efkqmyceef ltqflqvvfd qiekwgtgql wlsdeclyyi lnfveqcvvq kttwklvgph 361 ynvilqhvif pllkptaetl eafdndpqey inrnmdfwdv gyspdlaala llttcvtkrg 421 kttlqptlef mvstlqsavg dynnimldna lqiesclrif ssiidrlitk dspfasemek 481 filtyvlpff ksqygflqsr vcdicsklgs mdfkdpvits tiyegvmncl nnssnslpve 541 ltaalalqtf isddqfnmkl sehvvptmqk llslsndfes dvisgvmqdf veqfaeqlqp 601 fgvelmntlv qqflklaidl hetsnldpds ftnvdsipde sdkqmaalgi lsttisills 661 fenspeilkn leqsfypaae filkndiedf yreccefven stfllrditp iswkilelig 721 ecnrkpdsmv syylsdfmla lnniliygrn elkknefytk iifeiyqkav taednslddl 781 rvvfdlsqel vlalddslpq qyrerlladv vgsiltqkne lktnvvfsvt afnvvisnmi 841 teplitlqyl kqqgcleiff qtwitdyipn ykrcydikls vlallkiilk lesndysvln 901 lenlvpqlgs ivtqlasrlp talrqlanqr kefsssgfee dtkwdenfld vgdddendde 961 gdltekylel iknradsldf vdgydaketf ddleedpltg sildtvdvyk vfkesianlq 1021 hvdsnryqgi lrhltpadqe lfmgimna // LOCUS NP_012667 209 aa linear PLN 30-JUN-2025 DEFINITION xanthine phosphoribosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012667 VERSION NP_012667.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181791.1 REFERENCE 1 (residues 1 to 209) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 209) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 209) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 209) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08917. Method: conceptual translation. FEATURES Location/Qualifiers source 1..209 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..209 /product="xanthine phosphoribosyltransferase" /calculated_mol_wt="23540" Region 1..195 /region_name="Hpt1" /note="Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; COG2236" /db_xref="CDD:441837" CDS 1..209 /gene="XPT1" /locus_tag="YJR133W" /coded_by="NM_001181791.1:1..630" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004422 hypoxanthine phosphoribosyltransferase activity [PMID:10217799]" /experiment="EXISTENCE:genetic interaction:GO:0046100 hypoxanthine metabolic process [PMID:10217799]" /experiment="EXISTENCE:mutant phenotype:GO:0000310 xanthine phosphoribosyltransferase activity [PMID:10217799]" /experiment="EXISTENCE:mutant phenotype:GO:0032265 XMP salvage [PMID:10217799]" /note="Xanthine-guanine phosphoribosyl transferase; required for xanthine utilization and for optimal utilization of guanine" /db_xref="GeneID:853597" /db_xref="SGD:S000003894" ORIGIN 1 maenermyis ynnihklcqg vakhilarne rpdiiiaitg ggmipariir sflktkgqkn 61 ipiqaiglsl yedlgldnsv etigkevirt qwldfgalnq hfdsligkkv livdevddtr 121 ttlhyavsel ekeiaeqqkv lnrmseetvi sifvlhnkdk pkraglpdsm mnsgryiaaq 181 tvpdkwlcyp wdaedieeht mlakaqghd // LOCUS NP_012668 707 aa linear PLN 30-JUN-2025 DEFINITION Sgm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012668 VERSION NP_012668.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181792.3 REFERENCE 1 (residues 1 to 707) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 707) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 707) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 707) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 707) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08918. On Jul 30, 2012 this sequence version replaced NP_012668.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..707 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..707 /product="Sgm1p" /calculated_mol_wt="81040" Region 122..>438 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 585..693 /region_name="TMF_TATA_bd" /note="TATA element modulatory factor 1 TATA binding; pfam12325" /db_xref="CDD:432481" CDS 1..707 /gene="SGM1" /locus_tag="YJR134C" /coded_by="NM_001181792.3:1..2124" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /note="hypothetical protein; required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus" /db_xref="GeneID:853598" /db_xref="SGD:S000003895" ORIGIN 1 mskklsleer lslatkkgrk knkrstsnls spspvvlsnn eqesartsid daaagvvsid 61 naeniddpav rsestvegdt gkadsiavdd vvhpdhnrtd cfddtmvslp twlpknytef 121 tveelvkeis peylrlnkqi ddltnelnrk sqiettdssf fklikekddl idqlrkegak 181 laetelrqsn qikalrtkvk dleyevseln dssaqsveny nelqslyhni qgqlaeatnk 241 lkdadkqkes letleknike kddlitilqq sldnmrtlle keksefqtek kalqeatvdq 301 vttletkleq lrieldsstq nldaksnrdf vddqqsyeek qhasfqynrl keqlesskan 361 wdsieyalnt kivnlenrfe stmkekndie ekyqtalrss etlgkqleke kenhskavle 421 vkdlerraet lksslqsisd dynllkkkye iqrsqleqke nelkphqens nekiidkipv 481 eltdslnsme gniedewtlp qensmlslsm sklgelesdp slkpiynesh eticseesqh 541 fdrknvdfsi ddipeeaaal qairegesmn slnntsipyr rasvqlsnsn ghisahlvnk 601 lstelkrleg elsaskelyd nllkektkan deilrlleen dkfnevnkqk ddllkrveqm 661 qskletslql lgekteqvee lendvsdlke mmhqqvqqmv emqgkmr // LOCUS NP_012669 239 aa linear PLN 30-JUN-2025 DEFINITION Mcm22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012669 VERSION NP_012669.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181793.1 REFERENCE 1 (residues 1 to 239) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 239) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 239) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 239) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08919. Method: conceptual translation. FEATURES Location/Qualifiers source 1..239 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..239 /product="Mcm22p" /calculated_mol_wt="27436" Region 137..234 /region_name="MCM22_CTD" /note="C-terminal domain of inner kinetochore subunit MCM22 and similar proteins; cd22646" /db_xref="CDD:439351" Site order(138,141,144..145,148..149,151..152,155,159..160,163, 182,186,203,205..207,209..213,232..234) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:439351" CDS 1..239 /gene="MCM22" /locus_tag="YJR135C" /coded_by="NM_001181793.1:1..720" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11782448]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11782448]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /note="Outer kinetochore protein and component of the Ctf3 subcomplex; binds to centromeric DNA in a Ctf19p-dependent manner; involved in chromosome segregation and minichromosome maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-K and fission yeast sim4" /db_xref="GeneID:853599" /db_xref="SGD:S000003896" ORIGIN 1 mdvekdvldv yiknlenqig nkryflkqaq gaideitkrs ldtegkpvns evftellrkp 61 mffseradpi gfsltsnfls lraqsssewl slmndqsvdq kamlllqnni nsdlkellrk 121 lqhqmtimds kkqdhahirt rkarnkelwd sladflkgyl vpnlddndes idsltnevml 181 lmkrliehdl nltlndfssk tipiyrlllr aniitviegs tnpgtkyikl idfnetslt // LOCUS NP_058168 87 aa linear PLN 30-JUN-2025 DEFINITION protein transporter TIM8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_058168 VERSION NP_058168.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184382.1 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 87) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08920. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..87 /product="protein transporter TIM8" /calculated_mol_wt="9633" Region 23..85 /region_name="zf-Tim10_DDP" /note="Tim10/DDP family zinc finger; pfam02953" /db_xref="CDD:460764" CDS 1..87 /gene="TIM8" /locus_tag="YJR135W-A" /coded_by="NM_001184382.1:1..264" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0042719 mitochondrial intermembrane space protein transporter complex [PMID:12221072]" /experiment="EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:10051608|PMID:10469659]" /experiment="EXISTENCE:direct assay:GO:0140318 protein transporter activity [PMID:10469659|PMID:10051608]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:10469659]" /experiment="EXISTENCE:mutant phenotype:GO:0140318 protein transporter activity [PMID:10469659]" /experiment="EXISTENCE:physical interaction:GO:0042719 mitochondrial intermembrane space protein transporter complex [PMID:10051608]" /note="Mitochondrial intermembrane space protein; forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome, also known as deafness-dystonia-optic neuronopathy (DDON) syndrome; human TIMM8A can complement yeast null mutant" /db_xref="GeneID:853600" /db_xref="SGD:S000007348" ORIGIN 1 msslstsdla slddtskkei atflegensk qkvqmsihqf tnicfkkcve svndsnlssq 61 eeqclsncvn rfldtniriv nglqntr // LOCUS NP_012670 421 aa linear PLN 30-JUN-2025 DEFINITION Tti2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012670 VERSION NP_012670.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181794.3 REFERENCE 1 (residues 1 to 421) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 421) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 421) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 421) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08921. On Jul 30, 2012 this sequence version replaced NP_012670.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..421 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..421 /product="Tti2p" /calculated_mol_wt="48518" Region 46..331 /region_name="Tti2" /note="Tti2 family; pfam10521" /db_xref="CDD:431336" CDS 1..421 /gene="TTI2" /locus_tag="YJR136C" /coded_by="NM_001181794.3:1..1266" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0110078 TTT Hsp90 cochaperone complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:27172216]" /experiment="EXISTENCE:mutant phenotype:GO:0031669 cellular response to nutrient levels [PMID:27172216]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:27172216]" /experiment="EXISTENCE:mutant phenotype:GO:0071472 cellular response to salt stress [PMID:27172216]" /note="Subunit of the TTT complex and regulator of telomere length; subunit of the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; involved in the cellular stress response; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm; similar to S. pombe Tti2p" /db_xref="GeneID:853601" /db_xref="SGD:S000003897" ORIGIN 1 mtavtdiide lndsslsstr lrelclqlrk ktdtgcaitv sdevnliesl syhsispgvd 61 iqintdvlqt idyyfqrnks ehdeimcvli sklqplllkr ksnfelkeqr nlglkptlgm 121 slkednlmqa wvsqgglkgi plfyvillhl krrdistnls wiipgilnil ddttdirrik 181 lrgvlllqtl lnhtfmnetn dskwiqfsst glfplfektl inmcyflpps ynadetiaiw 241 rvvfptiqsl ykvefldnyt kyqyhlekfm seiilqniip raslayenlt lyalectmni 301 lrlqregsvv hlqrlifvlg eyivrnpfyt tfpklisktl svvstlikvc pnerivahrf 361 dilslilvty dkcsqedaln esilqqcket iswllncdca mgeqlstlsk qprfqllfef 421 s // LOCUS NP_116579 1442 aa linear PLN 30-JUN-2025 DEFINITION sulfite reductase (NADPH) subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_116579 VERSION NP_116579.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181795.1 REFERENCE 1 (residues 1 to 1442) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1442) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1442) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1442) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08922. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1442 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1442 /product="sulfite reductase (NADPH) subunit beta" /EC_number="1.8.1.2" /calculated_mol_wt="161089" Region 347..664 /region_name="TPP_enzymes" /note="Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; cl01629" /db_xref="CDD:470272" Site order(482..485,511,513) /site_type="other" /note="TPP-binding site [chemical binding]" /db_xref="CDD:239472" Region 678..>874 /region_name="CysJ" /note="Flavoprotein (flavin reductase) subunit CysJ of sulfite and N-hydroxylaminopurine reductases [Nucleotide transport and metabolism, Inorganic ion transport and metabolism]; COG0369" /db_xref="CDD:440138" Region 843..1434 /region_name="PRK13504" /note="NADPH-dependent assimilatory sulfite reductase hemoprotein subunit" /db_xref="CDD:237402" CDS 1..1442 /gene="MET5" /locus_tag="YJR137C" /gene_synonym="ECM17" /coded_by="NM_001181795.1:1..4329" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004783 sulfite reductase (NADPH) activity [PMID:6751400]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009337 sulfite reductase complex (NADPH) [PMID:6751400|PMID:9003798]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000097 sulfur amino acid biosynthetic process [PMID:1479340]" /experiment="EXISTENCE:mutant phenotype:GO:0000103 sulfate assimilation [PMID:19236486]" /note="Sulfite reductase beta subunit; involved in amino acid biosynthesis, transcription repressed by methionine" /db_xref="GeneID:853602" /db_xref="SGD:S000003898" ORIGIN 1 mtasdlltlp qllaqysssa pqnkvfytts tknshssfkg lesvatdath llnnqdplnt 61 ikdqlskdil ttvftdettl vksihhlysl pnklplvitv dlnlqdysai palkdlsfpi 121 lissdlqtai snadssykia tssltpvfhf lnlekigtst aieqdidfpt leianeetkv 181 alseatdslt nfelvkgkes ittvivnlsp ydaefssvlp snvglikirv yrpwnfskfl 241 eilpssvtki avlqgvskks qsnefqpfll dffgnfnelv srnieqvvlt nignvndygn 301 vintvisnin kkepdnnlfl gesnekaeeq aevtqlissv kkvvnleday ikvlkqlfss 361 nlqilnqfss etiepsnpef gfgrflkqea qreelislak tsldpslyls edankivqll 421 skwlsfngrd ldeaqlqean atgleifqll qsnqdsstvl kflkiaptsd sfifksswli 481 gsdawsydlg hsgiqqvlss rkninvllid sepydhrkqn qdrkkdvgly amnyysayva 541 svavyasytq lltaiieask yngpsivlay lpynsendtp levlketkna vesgywplyr 601 fnpvyddpst dkeafsldss virkqlqdfl drenkltllt rkdpslsrnl kqsagdaltr 661 kqekrskaaf dqlleglsgp plhvyyasdg gnaanlakrl aarasarglk atvlsmddii 721 leelpgeenv vfitstagqg efpqdgksfw ealkndtdld laslnvavfg lgdseywprk 781 edkhyfnkps qdlfkrlell sakaliplgl gddqdadgfq taysewepkl wealgvsgaa 841 vddepkpvtn edikresnfl rgtisenlkd tssggvthan eqlmkfhgiy tqddrdirei 901 rksqglepyy mfmararlpg gkttpqqwla ldhlsdtsgn gtlklttrat fqihgvlkkn 961 lkhtlrgmna vlmdtlaaag dvnrnvmvsa lptnakvhqq iadmgklisd hflpkttayh 1021 evwlegpeeq dddpswpsif enrkdgprkk ktlvsgnalv diepiygpty lprkfkfnia 1081 vppyndvdvl sidvglvaiv npetqivegy nvfvgggmgt thnnkktypr lgsclgfvkt 1141 ediipplegi vivqrdhgdr kdrkharlky tvddmgvegf kqkveeywgk kfeperpfef 1201 ksnidyfgwi kdetglnhft afiengrved tpdlpqktgi rkvaeymlkt nsghfrltgn 1261 qhlvisnitd ehvagiksil ktykldntdf sglrlssssc vglptcglaf aeserflpdi 1321 itqledclee yglrhdsiim rmtgcpngcs rpwlgelalv gkaphtynlm lgggylgqrl 1381 nklykanvkd eeivdyikpl fkryaleree gehfgdfcir vgiikptteg kyfhedvsed 1441 ay // LOCUS NP_012672 1584 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein IML1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012672 VERSION NP_012672.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181796.2 REFERENCE 1 (residues 1 to 1584) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1584) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1584) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1584) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08923. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1584 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1584 /product="GTPase-activating protein IML1" /calculated_mol_wt="181819" Region 208..484 /region_name="IML1" /note="Vacuolar membrane-associated protein Iml1; pfam12257" /db_xref="CDD:463510" Region 1188..1271 /region_name="DEP_DEPDC5-like" /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC5-like proteins. DEPDC5, in human also known as KIAA0645, is a DEP domain containing protein of unknown function; cd04449" /db_xref="CDD:239896" Region <1346..>1506 /region_name="DEPDC5_CTD" /note="DEPDC5 protein C-terminal region; pfam19418" /db_xref="CDD:466071" CDS 1..1584 /gene="IML1" /locus_tag="YJR138W" /gene_synonym="SEA1" /coded_by="NM_001181796.2:1..4755" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:23716719]" /experiment="EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]" /experiment="EXISTENCE:direct assay:GO:1990130 GATOR1 complex [PMID:21900499]" /experiment="EXISTENCE:genetic interaction:GO:0032007 negative regulation of TOR signaling [PMID:23716719]" /experiment="EXISTENCE:genetic interaction:GO:0051058 negative regulation of small GTPase mediated signal transduction [PMID:23716719]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:23716719]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0032007 negative regulation of TOR signaling [PMID:23974112]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:35158208]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:23716719]" /experiment="EXISTENCE:mutant phenotype:GO:2000785 regulation of autophagosome assembly [PMID:21900499]" /note="GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex; SEACIT (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy, and is a subcomplex of the SEA, a coatomer-related complex that associates with the vacuole; Iml1p functions as a GAP for the Rag family GTPase Gtr1p (EGOC subunit) in SEACIT, resulting in the inhibition of TORC1 signaling in response to amino acid deprivation; role in the oxidative stress response" /db_xref="GeneID:853603" /db_xref="SGD:S000003899" ORIGIN 1 mfaklhgkkq rpissinsqt prtsntthan sislssgnli vgsnrnlrqk keqfgsqqra 61 sgrklisnke nddnvnnggd nnydngervh rhhipglkik ayqaelgyhe srfsenlvml 121 nlvefpdikp gdlvelktyh knpsasngdk kiyfiakdfd getkrrakts nvsilsgqlq 181 tlldlpsrsr iwiklkpnkf dlqadvvefn ikdcllnrgd mwvlssklvd tcvfmdqrla 241 fldsirgtik giyrngkkiv sgyigeqtri ifrsesarli fliqitdemw nfeetgeqlf 301 qkmvnsffpk ifkkwkdvdt hhtitiafai smdlsdtsfk dltpgeslkn sqdyfrivvd 361 qvsiihwvdi metlreefme irkdllnkqt dkgysvangr fspviksnfl elvnfattil 421 tdpfkqldlr httthvmiis pgsglfdvdy sllrltgkkl lslemtmdli clskaplhiv 481 plfryrdfen klhhcvplwl svffwndhdk ksnsewtprc kiydlqmmgi tenelirevd 541 veylqlnkkv kslsefmndy dknafevkil cagsntkqsk klnskfdtvf endvvvkark 601 ipatattthg ntkfiwrgpk valpaikdiq kpnvipdlsi ktieasfydd cnttndkist 661 pttsnndnle mndslvsvrs adnqntslal dslkglskrn slkdftqrvi tkfisnidts 721 knkkikstll rddvdnsplg sntplpsses kisglklqqk gladenvisk rgnliikknl 781 sifglpsnei msgspssylg sshtrtsskl snmsdkaafi tegqkskhdd sntysltqql 841 khrisetwvd ikspsipvss efanellpir wkdvwpkyva rkyskwrsft tpaelpitis 901 dfpskddfdr nfifrnhsvt lntdqeqynq tykdllrdmi ymrlltgfqi cvgrqvekie 961 lsresgeset vvnkyldfnq ndafklylmi dseihritcs ssgiidvery lrkdeanlfd 1021 qvpsyiplvk tryessfrda midplhvkre slnwnqidqv lagygdnlid rkwhgfraky 1081 vvlptdippn tysmvingks etlnpeeirv eglrrligsi trsrlrteke kkgrktkree 1141 iqpevmfytg plynfineqq tslessainf kdsifvndnn llnrnvelsk layqiqrged 1201 ritlvnrkwh wkkhekcfvg semvnwlirn fsdidtreda ikygqkvmke glfvhvlnkh 1261 nfldghyfyq fspeyvmdtn klektnshrs tlsdpkqmlr kastgssndp samtpfssvv 1321 paisasnasv adakepsrpi lmlsnslvid vdpagksskq esctvhydrv hnpdhcfhir 1381 lewltttpkl iddlvgnwsr lceryglkmi eipweelcti psvnpfhsfv eiklainpwe 1441 dpefkdrelf akskfyyhvy llkasgflld nraskflqnq diefdimysw gkpqfkyvqy 1501 ihhtgayvae lrengclfla pnniyisrvn pgniigkihs assssldaqk vilnfkstcl 1561 dyqklrsifl dakemwitgk ived // LOCUS NP_012673 359 aa linear PLN 30-JUN-2025 DEFINITION homoserine dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012673 VERSION NP_012673.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181797.3 REFERENCE 1 (residues 1 to 359) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 359) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 359) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 359) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08924. On Jul 30, 2012 this sequence version replaced NP_012673.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..359 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..359 /product="homoserine dehydrogenase" /EC_number="1.1.1.3" /calculated_mol_wt="38371" Region <2..335 /region_name="thrA" /note="bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; PRK09436" /db_xref="CDD:181856" CDS 1..359 /gene="HOM6" /locus_tag="YJR139C" /gene_synonym="THR6" /coded_by="NM_001181797.3:1..1080" /experiment="EXISTENCE:direct assay:GO:0004412 homoserine dehydrogenase activity [PMID:11341915]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:4380684]" /experiment="EXISTENCE:mutant phenotype:GO:0009088 threonine biosynthetic process [PMID:4380684]" /experiment="EXISTENCE:mutant phenotype:GO:0009090 homoserine biosynthetic process [PMID:4380684]" /note="Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase); dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions" /db_xref="GeneID:853604" /db_xref="SGD:S000003900" ORIGIN 1 mstkvvnvav igagvvgsaf ldqllamkst itynlvllae aersliskdf splnvgsdwk 61 aalaasttkt lplddliahl ktspkpvilv dntssayiag fytkfvengi siatpnkkaf 121 ssdlatwkal fsnkptngfv yheatvgagl piisflreii qtgdevekie gifsgtlsyi 181 fnefstsqan dvkfsdvvkv akklgytepd prddlngldv arkvtivgri sgvevespts 241 fpvqslipkp lesvksadef leklsdydkd ltqlkkeaat enkvlrfigk vdvatksvsv 301 giekydyshp faslkgsdnv isiktkrytn pvviqgagag aavtaagvlg dvikiaqrl // LOCUS NP_012674 1648 aa linear PLN 30-JUN-2025 DEFINITION Hir3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012674 VERSION NP_012674.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181798.1 REFERENCE 1 (residues 1 to 1648) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1648) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1648) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1648) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08925. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1648 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1648 /product="Hir3p" /calculated_mol_wt="191550" CDS 1..1648 /gene="HIR3" /locus_tag="YJR140C" /gene_synonym="HPC1" /coded_by="NM_001181798.1:1..4947" /experiment="EXISTENCE:direct assay:GO:0000417 HIR complex [PMID:16264190|PMID:16303565]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16264190]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9001207]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:16264190|PMID:16303565]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:16449659]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:1406694]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:1406694]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:9001207]" /experiment="EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:16264190]" /experiment="EXISTENCE:physical interaction:GO:0000417 HIR complex [PMID:16264190]" /note="Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein" /db_xref="GeneID:853605" /db_xref="SGD:S000003901" ORIGIN 1 msmfnalnsn iegeqyeaee hsrelqieqs fnilqdalid lknkdfeksd skfqelfqid 61 vvkpdrwgmy rnssptldnl rylcyrnrgm yyhlylenny erlnsqelvn cilkavenlv 121 esiqhsdadf avtdllarif ksfnsvkler liseyeftkq enlslllgrh rkfllndltl 181 mmnnyveltn kllvpnlsdn tiferyhlek ykdikpepla fgpilsrise mkkqdeeimk 241 kldvfnvtln eeswdevaka lknllpsvkt ssligrnmdp yneieepiea vkfelseain 301 ntpsldrese rqeeeqdnes vraddksgnl apsdiqtnee arpnkrtdeh idstkplqrs 361 skrfkereqe nskelvmdvh krffgefntl lsyihilpfc dfdtfaskfi igssdkqpek 421 fipytdlyec lkswssrytd ifnqndylss gsneneelfq lnallksnaf ddkesfpryl 481 ndldsdhirs fisevnagnl hfhqvrlkll fkllgtydeg ngrrliidyl wesqllkivl 541 wfvfgiesni falinknkrq ckylalsiye llvnhlgniv eeitnkriqg hksadlksqr 601 nkvekrirsw htlleqiade kdkelyvhfq wthycflqyt cdivdsrlse tltslentik 661 dsdssldiay pnyrhipaln lntvqsqkrk iriiqnitve disedtnsdt hsenhletle 721 kvllhilhps tnhsnideem vsfifnspfl lkirlwgvlf ssyvkkssiq dvqriyfhvl 781 dfmkgaltsp vykesnphgr hqmlltvlta igylssqlta ilnsnrwess dfvledymfe 841 kllqtffffy tvlfyessav ndvsnksffk raskssgkmk dimidlatli lyyydlqakl 901 rtpaeqgiet teliwslhtl fghfhfcdas ngkfldlaek llcqfinnds flqlkqilwc 961 ryhyaiasdn fspdlhdtka vemekihslp lgtyliklqy qnknpylsss kttlkqimdn 1021 iiekigdpst ldnhiisrns fllneylsrp itadllkhtf sgatslylts pndelqqgmt 1081 aglfyvsslq slglykmrkk smqarpseld siirmlkndi iyntnrfesw illgkcysyi 1141 veddliwtsd kitvpekkdv ialtqrkail cylmaisiyy skldrtiddk kiilealddl 1201 gsmlisgyyn pmnklcfswk ssaentmrls etgevvmekt kkittisdfn ieqsiflcfn 1261 racslsgdik sqddvfvlnw ssfynlakff fktdggnnck lvakyitqgc qiayesspak 1321 dpiiephyll vnacykwvkr gvigvnealt llskdnqffq eqeefwvnde glawdyqekf 1381 ffdkiirllr hllsvdkkkw qhrpryriar ilfddlgdvn galeemdsli saksinknlv 1441 niwkpdferp gkhfiytyqy lvlyldllfa ikdfnttglv ikklrrfgsg tvnvneller 1501 ainvytqsak iklqlqdksy veqilptlny qeflkiseql nqvfdqgkyp eeissglkla 1561 fqlkkghsgi afdsvclgiy feylyfplar qdqsltdvnd ennpalpssg svtskstpdp 1621 tskpsaikkr vtkkevfdrv rllvdkit // LOCUS NP_012675 347 aa linear PLN 30-JUN-2025 DEFINITION putative polyadenylation protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012675 VERSION NP_012675.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181799.1 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 347) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08926. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..347 /product="putative polyadenylation protein" /calculated_mol_wt="39771" Region 4..347 /region_name="COG5629" /note="Predicted metal-binding protein [Function unknown]" /db_xref="CDD:227916" CDS 1..347 /gene="IPA1" /locus_tag="YJR141W" /coded_by="NM_001181799.1:1..1044" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:29519818]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:29519818]" /experiment="EXISTENCE:mutant phenotype:GO:0031397 negative regulation of protein ubiquitination [PMID:32009536]" /experiment="EXISTENCE:mutant phenotype:GO:0031442 positive regulation of mRNA 3'-end processing [PMID:32009536]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:29519818]" /experiment="EXISTENCE:physical interaction:GO:0031624 ubiquitin conjugating enzyme binding [PMID:29519818]" /note="Protein implicated in pre-mRNA processing and proteasomal degradation; interacts physically and genetically with mRNA cleavage and polyadenylation factors; mutant is impaired in pre-mRNA cleavage and polyadenylation; associates with several Ub-conjugating enzymes and alters Ub-mediated proteasome activity; localizes to both the nucleus and cytosol; contains a HECT_2 domain; homologous to human ubiquitin-protein ligase, UBE3D, a gene implicated in age-related macular degeneration" /db_xref="GeneID:853606" /db_xref="SGD:S000003902" ORIGIN 1 mvqyvvewlp riqsisvvve gwkqveiknl kdtlmsisgd eeqvedillp veveekvdas 61 ykfknrgkdl ewmtklrsks skiydssims lpdgrwtkee lrsdsdfsie clnckqkiis 121 kdncqvlndm psefwfelmd ywhchkpdvk edkssytrfe tlkpskneil igssyfqgtp 181 atfenvattk endnvlcikc savlgqvtag slyklhkwkl qlirsgntyk fppecditis 241 linvvkansc ryvlvkckte sllvwifsvd igvtltgnks fkramkllyt nsvttinrcl 301 nrqvveeldf qetsfnafys alqhtnallp ssmkkigewt isytsli // LOCUS NP_012676 342 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR142W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012676 VERSION NP_012676.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181800.3 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 342) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08927. On Jul 30, 2012 this sequence version replaced NP_012676.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..342 /product="uncharacterized protein" /calculated_mol_wt="39559" Region <80..153 /region_name="DUF4743" /note="Domain of unknown function (DUF4743); pfam15916" /db_xref="CDD:406365" Region 150..314 /region_name="NUDIX_Tnr3_like" /note="thiamine diphosphokinase Tnr3 from Schizosaccharomyces pombe and similar proteins; cd03676" /db_xref="CDD:467544" CDS 1..342 /locus_tag="YJR142W" /coded_by="NM_001181800.3:1..1029" /experiment="EXISTENCE:direct assay:GO:0044715 8-oxo-dGDP phosphatase activity [PMID:23834287]" /note="8-oxo-dGTP diphosphatase of the Nudix hydrolase family; converts diphosphates of damaged forms of thiamin to monophosphates; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition" /db_xref="GeneID:853607" /db_xref="SGD:S000003903" ORIGIN 1 mkveksskgl evlvrtqedd legfsfleim drvdplpldf enyknfkegi yymcthdgtk 61 igfvlkfain emetvcseif eetfqldesr helrfksedf dhrnnlidql arkmylessl 121 sgvkgwrnek yavwvnkkpy vlveravagv lgiitygihi ngyvldpksk kvqfwvprrs 181 ktkqtwplml dniiagglgy pygiyetvlk esmeeanlek sviednikat gsvsylyftg 241 disvtkfnke sdfivgevqy vydlklsedi ipkpndgeve sfnlfslqet inalrkkefk 301 pncalvmvdf lirhgyitpe nepnylelvt rmhrrlpfpt ln // LOCUS NP_012677 762 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-phosphate-mannose-protein mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012677 VERSION NP_012677.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181801.1 REFERENCE 1 (residues 1 to 762) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 762) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 762) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 762) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 762) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08928. Method: conceptual translation. FEATURES Location/Qualifiers source 1..762 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..762 /product="dolichyl-phosphate-mannose-protein mannosyltransferase" /EC_number="2.4.1.109" /calculated_mol_wt="87836" Region 58..305 /region_name="PMT" /note="Dolichyl-phosphate-mannose-protein mannosyltransferase; pfam02366" /db_xref="CDD:396786" Region 334..521 /region_name="beta-trefoil_MIR_PMT4-like" /note="MIR domain, beta-trefoil fold, found in Saccharomyces cerevisiae dolichyl-phosphate-mannose--protein mannosyltransferase 4 (PMT4) and similar proteins; cd23285" /db_xref="CDD:467756" Site order(431,486,488,508,513) /site_type="other" /note="putative heterodimer interface [polypeptide binding]" /db_xref="CDD:467756" Region 543..755 /region_name="PMT_4TMC" /note="C-terminal four TMM region of protein-O-mannosyltransferase; pfam16192" /db_xref="CDD:465056" CDS 1..762 /gene="PMT4" /locus_tag="YJR143C" /coded_by="NM_001181801.1:1..2289" /experiment="EXISTENCE:direct assay:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:21956107]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:21231968]" /experiment="EXISTENCE:mutant phenotype:GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity [PMID:8585318|PMID:21956107]" /experiment="EXISTENCE:mutant phenotype:GO:0006493 protein O-linked glycosylation [PMID:8585318]" /experiment="EXISTENCE:mutant phenotype:GO:0035269 protein O-linked mannosylation [PMID:21231968|PMID:18182384]" /experiment="EXISTENCE:physical interaction:GO:0097586 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex [PMID:12551906]" /note="Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals" /db_xref="GeneID:853608" /db_xref="SGD:S000003904" ORIGIN 1 msvpkkrnhg klppstkdvd dpslkytkaa pkceqvaehw llqplpepes rysfwvtivt 61 llafaarfyk iwypkevvfd evhfgkfasy ylersyffdv hppfakmmia figwlcgydg 121 sfkfdeigys yethpapyia yrsfnailgt ltvpimfntl kelnfraitc afasllvaid 181 tahvtetrli lldailiisi aatmycyvrf ykcqlrqpft wswyiwlhat glslsfvist 241 kyvgvmtysa igfaavvnlw qlldikagls lrqfmrhfsk rlnglvlipf viylfwfwvh 301 ftvlntsgpg dafmsaefqe tlkdsplsvd sktvnyfdii tikhqdtdaf lhshlarypq 361 ryedgrissa gqqvtgythp dfnnqwevlp phgsdvgkgq avllnqhirl rhvatdtyll 421 ahdvaspfyp tneeittvtl eegdgelype tlfafqplkk sdeghvlksk tvsfrlfhvd 481 tsvalwthnd ellpdwgfqq qeingnkkvi dpsnnwvvde ivnldevrkv yipkvvkplp 541 flkkwietqk smfehnnkls sehpfasepy swpgslsgvs fwtngdekkq iyfigniigw 601 wfqvislavf vgiivadlit rhrgyyalnk mtreklygpl mfffvswcch yfpfflmarq 661 kflhhylpah liaclfsgal wevifsdcks ldlekdedis gasyernpkv yvkpytvflv 721 cvscavawff vyfsplvygd vslspsevvs rewfdielnf sk // LOCUS NP_012678 269 aa linear PLN 30-JUN-2025 DEFINITION Mgm101p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012678 VERSION NP_012678.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181802.1 REFERENCE 1 (residues 1 to 269) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 269) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 269) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 269) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08929. Method: conceptual translation. FEATURES Location/Qualifiers source 1..269 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..269 /product="Mgm101p" /calculated_mol_wt="29959" Region 100..269 /region_name="Mgm101p" /note="Mitochondrial genome maintenance MGM101; pfam06420" /db_xref="CDD:428931" CDS 1..269 /gene="MGM101" /locus_tag="YJR144W" /gene_synonym="MGM9" /coded_by="NM_001181802.1:1..810" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:22948312]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10209025|PMID:10869431]" /experiment="EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:23536705]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:22027892]" /experiment="EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:22948312]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:10209025]" /note="Protein with a role in mitochondrial DNA recombinational repair; also involved in interstrand cross-link repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity but sharing conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage and mitochondrial genome maintenance" /db_xref="GeneID:853609" /db_xref="SGD:S000003905" ORIGIN 1 mksifkvrgc vshaaqfcqk rtvvstgtsn tatagavrks fnstetkpvf atkseagngs 61 hmkeyssgin sklggtplet rstaddslnn sykqvkgdid wytswyglgm kpfeakvqkd 121 liepldpkdi eikpdgliyl peikyrriln kafgaggwgl vprsqtivts klvtreygli 181 chgqlisvar geqdyfneag iptategcks nalmrcckdl gvgselwdpv fikkfkvdhc 241 tekfvehvtt krkkkiwlrk drqveypyk // LOCUS NP_012679 261 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS4 RPS4A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012679 VERSION NP_012679.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181803.3 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 261) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08930. On Jul 30, 2012 this sequence version replaced NP_012679.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..261 /product="40S ribosomal protein eS4 RPS4A" /calculated_mol_wt="29279" Region 1..259 /region_name="PLN00036" /note="40S ribosomal protein S4; Provisional" /db_xref="CDD:177670" CDS 1..261 /gene="RPS4A" /locus_tag="YJR145C" /coded_by="NM_001181803.3:1..786" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /note="Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication" /db_xref="GeneID:853610" /db_xref="SGD:S000003906" ORIGIN 1 margpkkhlk rlaaphhwll dklsgcyapr psagphklre slplivflrn rlkyalngre 61 vkailmqrhv kvdgkvrtdt typagfmdvi tldatnenfr lvydvkgrfa vhritdeeas 121 yklgkvkkvq lgkkgvpyvv thdgrtiryp dpnikvndtv kidlasgkit dfikfdagkl 181 vyvtggrnlg rigtivhker hdggfdlvhi kdsldntfvt rlnnvfvige qgkpyislpk 241 gkgiklsiae erdrrraqqg l // LOCUS NP_001257683 117 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR146W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257683 VERSION NP_001257683.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270754.1 REFERENCE 1 (residues 1 to 117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 117) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35121. Method: conceptual translation. FEATURES Location/Qualifiers source 1..117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..117 /product="uncharacterized protein" /calculated_mol_wt="13040" CDS 1..117 /locus_tag="YJR146W" /coded_by="NM_001270754.1:1..354" /note="hypothetical protein; expressed at both mRNA and protein levels; partially overlaps HMS2" /db_xref="GeneID:853611" /db_xref="SGD:S000003907" ORIGIN 1 mkvgkakkkp eifsahcsva tafldpsffy pnfvaqkash yndktgsani wtyisrtgsl 61 llftqvvyrk skwthqsatf adciycqsgq spsvslscsd arqtwmqhrg wsslmsl // LOCUS NP_012681 358 aa linear PLN 30-JUN-2025 DEFINITION Hms2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012681 VERSION NP_012681.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181805.1 REFERENCE 1 (residues 1 to 358) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 358) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 358) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 358) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08931. Method: conceptual translation. FEATURES Location/Qualifiers source 1..358 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..358 /product="Hms2p" /calculated_mol_wt="41061" Region 1..279 /region_name="HSF1" /note="Heat shock transcription factor [Transcription]; COG5169" /db_xref="CDD:227497" CDS 1..358 /gene="HMS2" /locus_tag="YJR147W" /coded_by="NM_001181805.1:1..1077" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:9832522]" /note="Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; HMS2 has a paralog, SKN7, that arose from the whole genome duplication" /db_xref="GeneID:853612" /db_xref="SGD:S000003908" ORIGIN 1 mdatsrmeqp dvfvsklyhl lqgnaysnii qwstdgsklv iwnpdqftkv ilerffgiht 61 faafvkqlsk ynfqkagrpd cvefsnihfq kdninslslv kahqsaatpn vaavnnmnkq 121 ctfhwdpfkv nsilskaigk psfeklvknv drlqgnldel kstnadslri ireinaslqt 181 isyhqfhayq tanflqenfe aikkvvcpds clqhqqrqpk rpkrysllll ipnaselset 241 plmrfagvfe fmncsldtat qwhpqlhpea ydllfvtvsp nmqqehliyf krlrnllpsf 301 pviaiinrpv spqdtsiaps nysryyfhhf lqlgfsdilv spftptqlit llskhlrt // LOCUS NP_012682 376 aa linear PLN 30-JUN-2025 DEFINITION branched-chain-amino-acid transaminase BAT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012682 VERSION NP_012682.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181806.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 376) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08932. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..376 /product="branched-chain-amino-acid transaminase BAT2" /EC_number="2.6.1.42" /calculated_mol_wt="41494" Region 61..361 /region_name="BCAT_beta_family" /note="Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The...; cd01557" /db_xref="CDD:238798" Site order(61..65,68..72,74,76,107,144,146,152..154,158,165,204, 209,211,215,229) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:238798" Site order(71,76,100,156,202,207,237,270..271,317) /site_type="active" /note="substrate-cofactor binding pocket [active]" /db_xref="CDD:238798" Site 202 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:238798" CDS 1..376 /gene="BAT2" /locus_tag="YJR148W" /gene_synonym="ECA40; TWT2" /coded_by="NM_001181806.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0004084 branched-chain-amino-acid transaminase activity [PMID:8798704]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:21267457|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009082 branched-chain amino acid biosynthetic process [PMID:8798704]" /experiment="EXISTENCE:mutant phenotype:GO:0009082 branched-chain amino acid biosynthetic process [PMID:8798704]" /experiment="EXISTENCE:mutant phenotype:GO:0009083 branched-chain amino acid catabolic process [PMID:8702755]" /note="Cytosolic branched-chain amino acid (BCAA) aminotransferase; preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase; BAT2 has a paralog, BAT1, that arose from the whole genome duplication" /db_xref="GeneID:853613" /db_xref="SGD:S000003909" ORIGIN 1 mtlapldask vkitttqhas kpkpnselvf gksftdhmlt aewtaekgwg tpeikpyqnl 61 sldpsavvfh yafelfegmk ayrtvdnkit mfrpdmnmkr mnksaqricl ptfdpeelit 121 ligkliqqdk clvpegkgys lyirptligt taglgvstpd rallyviccp vgpyyktgfk 181 avrleatdya trawpggcgd kklganyapc vlpqlqaasr gyqqnlwlfg pnnnitevgt 241 mnaffvfkds ktgkkelvta pldgtilegv trdsilnlak erlepsewti seryftigev 301 terskngell eafgsgtaai vspikeigwk geqinipllp geqtgplake vaqwingiqy 361 getehgnwsr vvtdln // LOCUS NP_012683 404 aa linear PLN 30-JUN-2025 DEFINITION putative nitronate monooxygenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012683 VERSION NP_012683.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181807.4 REFERENCE 1 (residues 1 to 404) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 404) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 404) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 404) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08933. On Jul 30, 2012 this sequence version replaced NP_012683.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..404 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..404 /product="putative nitronate monooxygenase" /EC_number="1.13.12.16" /calculated_mol_wt="45028" Region 33..332 /region_name="NPD_like" /note="2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; cd04730" /db_xref="CDD:240081" Site order(41..42,104,174,196,217,221..222,270..272,291..294) /site_type="other" /note="FMN binding site [chemical binding]" /db_xref="CDD:240081" Site 224 /site_type="active" /note="putative catalytic residue [active]" /db_xref="CDD:240081" CDS 1..404 /locus_tag="YJR149W" /coded_by="NM_001181807.4:1..1215" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:853614" /db_xref="SGD:S000003910" ORIGIN 1 myflnqlifq dvsvmsvdkr edmsrsfqkc lnlrypiiqa pmagvttiem aakaciagai 61 aslplshldf rkvndieklk lmvsqfrdqv adeslegnln lnffchdivd kptdlqtanw 121 aklyrksmnv pidmneikfd ngnvsfkafe kenalqdffq ylsdgfrpki isfhfghpsk 181 stieylqkig ilifvtatsv revrllarlg ingivcqgye agghrgnflv ndpkddenls 241 tvqlvkrtvd elaemknkgl ihatpfviaa ggimdskdis ymlsqqadav qvgtaflgcs 301 esnasknfss pftretttkm vniisgkpar tistpfiekv ianfqgeelp pygymysafk 361 qvrkkypela nfilagqgfq nvqsgittdk kietmgarlk idgk // LOCUS NP_012684 298 aa linear PLN 30-JUN-2025 DEFINITION Dan1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012684 VERSION NP_012684.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181808.4 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 298) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08934. On Jul 30, 2012 this sequence version replaced NP_012684.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..298 /product="Dan1p" /calculated_mol_wt="29475" Region 25..117 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..298 /gene="DAN1" /locus_tag="YJR150C" /gene_synonym="CCW13" /coded_by="NM_001181808.4:1..897" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10322008]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:12077145]" /note="Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth" /db_xref="GeneID:853615" /db_xref="SGD:S000003911" ORIGIN 1 msrisilava aalvasataa svtttlspyd ervnlielav yvsdigahls eyyafqalhk 61 tetyppeiak avfaggdftt mltgisgdev trmitgvpwy strlmgaise alanegiata 121 vpastteass tstseassaa tesssssess aetssnaast qatvssesss aastiassae 181 ssvassvass vassasfant tapvsstssi svtpvvqngt dstvtktqas tvettitscs 241 nnvcstvtkp vsskaqstat svtssasrvi dvttngankf nngvfgaaai agaaalll // LOCUS NP_012685 1161 aa linear PLN 30-JUN-2025 DEFINITION Dan4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012685 VERSION NP_012685.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181809.2 REFERENCE 1 (residues 1 to 1161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1161) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 1161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08935. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..1161 /product="Dan4p" /calculated_mol_wt="118229" Region 28..117 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" Region <375..544 /region_name="rne" /note="ribonuclease E; Reviewed; PRK10811" /db_xref="CDD:236766" CDS 1..1161 /gene="DAN4" /locus_tag="YJR151C" /coded_by="NM_001181809.2:1..3486" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth" /db_xref="GeneID:853616" /db_xref="SGD:S000003912" ORIGIN 1 mvnisivagi valatsaaai tatttlspyd ervnlielav yvsdirahif qyysfrnhhk 61 tetypseiaa avfdygdftt rltgisgdev trmitgvpwy strlkpaiss alskdgiyta 121 iptststttt ksststtptt titsttstts ttpttsttst tpttsttstt pttsttsttp 181 ttsttsttpt tsttsttptt sttsttptts ttsttpttst tsttpttstt pttsttstts 241 qtstksttpt tsststtptt sttpttstts tapttsttst tsttstista pttsttsstf 301 stssasassv isttattstt faslttpats tastdhttss vsttnaftts atttttsdty 361 isssspsqvt ssaepttvse vtssveptrs sqvtssaept tvseftssve ptrssqvtss 421 aepttvseft ssveptrssq vtssaepttv seftssvept rssqvtssae pttvseftss 481 veptrssqvt ssaepttvse ftssvepirs sqvtssaept tvsevtssve pirssqvttt 541 epvssfgstf seitssaepl sfskattsae sissnqitis selivssvit ssseipssie 601 vltssgisss veptslvgps sdesisstes lsatstftsa vvssskaadf ftrstvsaks 661 dvsgnsstqs ttffatpstp lavsstvvts stdsvspnip fseissspes staitststs 721 fiaertssly lsssnmssft lstftvsqsi vssfsmepts svasfasssp llvssrsncs 781 darssntiss glfstienvr natstftnls tdeivitsck ssctnedsvl tktqvstvet 841 titscsggic ttlmspvtti nakantlttt etstvettit tcpggvcstl tvpvttitse 901 atttatisce dneeditste telltletti tscsggictt lmspvttina kantltttet 961 stvettittc sggvcstltv pvttitseat ttatiscedn eedvastkte lltmettits 1021 csggicttlm spvssfnska ttsnnaesti pkaikvscsa gacttlttvd agismftrtg 1081 lsitqttvtn csggtctmlt apiatatskv ispipkassa tsiahssasy tvsintngay 1141 nfdkdnifgt aivavvalll l // LOCUS NP_878108 16 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR151W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878108 VERSION NP_878108.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184556.1 REFERENCE 1 (residues 1 to 16) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 16) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 16) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 16) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 16) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 16) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 16) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08936. Method: conceptual translation. FEATURES Location/Qualifiers source 1..16 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..16 /product="uncharacterized protein" /calculated_mol_wt="1845" CDS 1..16 /locus_tag="YJR151W-A" /coded_by="NM_001184556.1:1..51" /note="hypothetical protein; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational 'guilt by association' analysis" /db_xref="GeneID:1466471" /db_xref="SGD:S000028557" ORIGIN 1 mlslifylrf psyirg // LOCUS NP_012686 543 aa linear PLN 30-JUN-2025 DEFINITION allantoate permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_012686 VERSION NP_012686.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181810.3 REFERENCE 1 (residues 1 to 543) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 543) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 543) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 543) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08937. On Jul 30, 2012 this sequence version replaced NP_012686.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..543 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..543 /product="allantoate permease" /calculated_mol_wt="60719" Region 80..496 /region_name="MFS_FEN2_like" /note="Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; cd17327" /db_xref="CDD:340885" Site order(96..97,100..101,104,137,190..191,193..195,198,218, 221..222,225,324,327..328,331..333,336,364,368,426..427, 431,435,452,455..456,459..460,463) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340885" CDS 1..543 /gene="DAL5" /locus_tag="YJR152W" /gene_synonym="UREP1" /coded_by="NM_001181810.3:1..1632" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0042938 dipeptide transport [PMID:17693598]" /experiment="EXISTENCE:genetic interaction:GO:0071916 dipeptide transmembrane transporter activity [PMID:17693598]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:3275614]" /experiment="EXISTENCE:mutant phenotype:GO:0015124 allantoate transmembrane transporter activity [PMID:3275614]" /experiment="EXISTENCE:mutant phenotype:GO:0015719 allantoate transport [PMID:3275614]" /experiment="EXISTENCE:mutant phenotype:GO:0042938 dipeptide transport [PMID:17693598|PMID:16429164]" /experiment="EXISTENCE:mutant phenotype:GO:0042939 tripeptide transport [PMID:16429164]" /experiment="EXISTENCE:mutant phenotype:GO:0071916 dipeptide transmembrane transporter activity [PMID:17693598|PMID:16429164]" /note="Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression" /db_xref="GeneID:853617" /db_xref="SGD:S000003913" ORIGIN 1 msadastnsn asldeknlni tseaeikned vtaepvlstv lspngkivyi sdkvdeamkl 61 aeeakeievt peedrklrwk idycmfplmc ilyavqfmdk istssaavmg lrtdlkmhgd 121 qyswvtsafy fgylfmnlgp vqfifqrtsh mskmlavfiv iwgmllalha aptvkypsfi 181 vlrvllgcae svvtpcftii taqywkteeq ftrvsiwfgm nglgsilina iaygvyihqd 241 syaikgwrtl fvitgvitif igiliflwip ddpskarfls kreklmvvqr irsnqqgfgn 301 heikkyqiie alkdvrtwly flftvssnip nggissfmsi llnsdfgyss ketllmglpt 361 gavelvgcpl fgilavyaan kkipfwkykl swaifaavla liascmlgfa tnskkarlag 421 aylwyispvs ficvlsnisa nssgyskkwt vssinlvaya aanlagpqtf iakqapkyhg 481 akvamvvcya vmivllsill ivnlrenkrr dkiaaergfp eetenlefsd ltdfenpnfr 541 ytl // LOCUS NP_012687 361 aa linear PLN 30-JUN-2025 DEFINITION endo-polygalacturonase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012687 VERSION NP_012687.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181811.3 REFERENCE 1 (residues 1 to 361) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 361) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 361) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 361) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08938. On Jul 30, 2012 this sequence version replaced NP_012687.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..361 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..361 /product="endo-polygalacturonase" /EC_number="3.2.1.15" /calculated_mol_wt="37156" Region 45..361 /region_name="Glyco_hydro_28" /note="Glycosyl hydrolases family 28; pfam00295" /db_xref="CDD:425588" CDS 1..361 /gene="PGU1" /locus_tag="YJR153W" /gene_synonym="PGL1; PSM1" /coded_by="NM_001181811.3:1..1086" /experiment="EXISTENCE:direct assay:GO:0004650 polygalacturonase activity [PMID:10650215]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:10028181|PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0045490 pectin catabolic process [PMID:10028181]" /note="Endo-polygalacturonase; pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins" /db_xref="GeneID:853618" /db_xref="SGD:S000003914" ORIGIN 1 misansllis tlcafaiatp lskrdsctlt gsslsslstv kkcssivikd ltvpagqtld 61 ltglssgttv tfegtttfqy kewsgplisi sgskisvvga sghtidgqga kwwdglgdsg 121 kvkpkfvkla ltgtskvtgl niknaphqvf sinkcsdlti sditidirdg dsagghntdg 181 fdvgsssnvl iqgctvynqd dciavnsgst ikfmnnycyn ghgisvgsvg grsdntvngf 241 waennhvins dnglriktve gatgtvtnvn fisnkisgik sygiviegdy lnskttgtat 301 ggvpisnlvm kditgsvnst akrvkilvkn atnwqwsgvs itggssysgc sgipsgsgas 361 c // LOCUS NP_012688 346 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YJR154W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012688 VERSION NP_012688.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181812.1 REFERENCE 1 (residues 1 to 346) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 346) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 346) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 346) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08939. Method: conceptual translation. FEATURES Location/Qualifiers source 1..346 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..346 /product="uncharacterized protein" /calculated_mol_wt="38841" Region 55..263 /region_name="PhyH" /note="Phytanoyl-CoA dioxygenase (PhyH); pfam05721" /db_xref="CDD:399029" CDS 1..346 /locus_tag="YJR154W" /coded_by="NM_001181812.1:1..1041" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:853619" /db_xref="SGD:S000003915" ORIGIN 1 mntdshnlse pyniggqkyi nmkkkedlgv cqpgltqkaf tvedkfdyka iiekmevygl 61 cvvknfiets rcdeilkeie phfyryeswq gspfpkettv atrsvlhsst vlkdvvcdrm 121 fcdiskhfln eenyfaagkv inkctsdiql nsgivykvga gasdqgyhre divhhtthqa 181 cerfqygtet mvglgvaftd mnkengstrm ivgshlwgph dscgnfdkrm efhvnvakgd 241 avlflgslyh aasanrtsqd rvagyffmtk sylkpeenlh lgtdlrvfkg lplealqllg 301 lgisepfcgh idykspghli ssslfendie kgyygetirv nygstq // LOCUS NP_012689 288 aa linear PLN 30-JUN-2025 DEFINITION putative aryl-alcohol dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012689 VERSION NP_012689.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181813.1 REFERENCE 1 (residues 1 to 288) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 288) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 288) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 288) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08940. Method: conceptual translation. FEATURES Location/Qualifiers source 1..288 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..288 /product="putative aryl-alcohol dehydrogenase" /calculated_mol_wt="32439" Region <1..250 /region_name="AKR_SF" /note="Aldo-keto reductase (AKR) superfamily; cl00470" /db_xref="CDD:444925" Site order(15,63,93..94,119,147..153,204,221..224,229,232..233) /site_type="active" /db_xref="CDD:381296" CDS 1..288 /gene="AAD10" /locus_tag="YJR155W" /coded_by="NM_001181813.1:1..867" /note="Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" /db_xref="GeneID:853620" /db_xref="SGD:S000003916" ORIGIN 1 masrklrdqi viatkfttdy kgydvgkgks anfcgnhkrs lhvsvrdslr klqtdwidil 61 yvhwwdymss ieevmdslhi lvqqgkvlyl gvsdtpawvv saanyyatsh gktpfsiyqg 121 kwnvlnrdfe rdiipmarhf gmalapwdvm gggrfqskka veerkkkgeg lrtffgtseq 181 tdmevkisea llkvaeehgt esvtaiaiay vrskakhvfp lvggrkiehl kqniealsik 241 ltpeqikyle sivpfdvgfp tnfigddpav tkkpsfltem sakisfed // LOCUS NP_012690 340 aa linear PLN 30-JUN-2025 DEFINITION 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012690 VERSION NP_012690.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181814.3 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 340) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08941. On Jul 30, 2012 this sequence version replaced NP_012690.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..340 /product="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" /calculated_mol_wt="38501" Region 5..255 /region_name="PBP2_THI5" /note="Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily; cd13650" /db_xref="CDD:270368" Site order(12,44,89,114,118,159..160,167,201) /site_type="other" /note="putative chemical substrate binding site [chemical binding]" /db_xref="CDD:270368" CDS 1..340 /gene="THI11" /locus_tag="YJR156C" /coded_by="NM_001181814.3:1..1023" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:12777485]" /note="Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" /db_xref="GeneID:853621" /db_xref="SGD:S000003917" ORIGIN 1 mstdkitfll nwqptpyhip iflaqtkgyf keqgldiail eptnpsdvte ligsgkvdmg 61 lkamihtlaa kargfpvtsv aslldepftg vlylkgsgit edfqslkgkk igyvgefgki 121 qideltkhyg mkpedytavr cgmnvakyii edkidagigi ecmqqvelee ylakqgrpas 181 dakmlridkl aclgcccfct vlyicndefl kknpekvrkf lkaikkatdy vladpvkawk 241 eyidfkpqln ndlsykqyqr cyayfsssly nvhrdwkkvt gygkrlailp pdyvsnytne 301 ylswpepeev sdpleaqrlm aihqekcrqe gtfkrlalpa // LOCUS NP_012692 567 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012692 VERSION NP_012692.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181816.3 REFERENCE 1 (residues 1 to 567) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 567) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 567) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 567) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08942. On Jul 30, 2012 this sequence version replaced NP_012692.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..567 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..567 /product="hexose transporter HXT16" /calculated_mol_wt="62790" Region 62..524 /region_name="MFS_HXT" /note="Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; cd17356" /db_xref="CDD:340914" Site order(74,78,205,208..209,212,331..332,336..337,340..341, 366,436..437,440..441,445,468..469,472) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..567 /gene="HXT16" /locus_tag="YJR158W" /gene_synonym="HLT3" /coded_by="NM_001181816.3:1..1704" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015795 sorbitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:genetic interaction:GO:0015797 mannitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose" /db_xref="GeneID:853623" /db_xref="SGD:S000003919" ORIGIN 1 maseqsspei nadnlnssaa dvhvqppgek ewsdgfydke vingntpdap krgflgylii 61 yllcypvsfg gflpgwdsgi tagfinmdnf kmnfgsykhs tgeyylsnvr mgllvamfsv 121 gcsiggvafa rladtlgrrl aivivvlvym vgaiiqissn hkwyqyfvgk iiyglgaggc 181 svlcpmllse iaptdlrggl vslyqlnmtf giflgycsvy gtrkysntaq wripvglcfl 241 waliiivgml lvpespryli ecerheeacv siakidkvsp edpwvlkqad einagvlaqr 301 elgeaswkel fsvktkvlqr litgilvqtf lqltgenyff fygttifksv gltdgfetsi 361 vlgtvnffst iiavmvvdki grrkcllfga asmmacmvif asigvkclyp hgqdgpsskg 421 agnamivftc fyifcfattw apvayivvae sfpskvkska msistafnwl wqfligfftp 481 fitgsihfyy gyvfvgclva mflyvffflp etiglsleet qllyeegikp wksaswvpps 541 rrgassrete akkkswkevl kfpksfn // LOCUS NP_012693 357 aa linear PLN 30-JUN-2025 DEFINITION L-iditol 2-dehydrogenase SOR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012693 VERSION NP_012693.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181817.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 357) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08943. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..357 /product="L-iditol 2-dehydrogenase SOR1" /EC_number="1.1.1.9" /calculated_mol_wt="38035" Region 8..353 /region_name="sorbitol_DH" /note="Sorbitol dehydrogenase; cd05285" /db_xref="CDD:176188" Site order(43,45,49,55,58,68,117,120,154,277,300..301) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:176188" Site order(43,45,68..69,154) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176188" Site order(98,101,104,112) /site_type="other" /note="structural Zn binding site [ion binding]" /db_xref="CDD:176188" Site order(158,180..182,201..203,207,222,252..253,255,275..277, 299..301) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:176188" Site order(160,171,173,189,192..194,196,205,221,239,309, 312..313,316) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:176188" CDS 1..357 /gene="SOR1" /locus_tag="YJR159W" /gene_synonym="SDH1" /coded_by="NM_001181817.1:1..1074" /experiment="EXISTENCE:direct assay:GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity [PMID:8125328]" /experiment="EXISTENCE:expression pattern:GO:0019318 hexose metabolic process [PMID:8125328]" /experiment="EXISTENCE:mutant phenotype:GO:0003939 L-iditol 2-dehydrogenase (NAD+) activity [PMID:26996892]" /note="Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose" /db_xref="GeneID:853624" /db_xref="SGD:S000003920" ORIGIN 1 msqnsnpavv lekvgdiaie qrpiptikdp hyvklaikat gicgsdihyy rsggigkyil 61 kapmvlghes sgqvvevgda vtrvkvgdrv aiepgvpsry sdetkegryn lcphmafaat 121 ppidgtlvky ylspedflvk lpegvsyeeg acveplsvgv hsnklagvrf gtkvvvfgag 181 pvglltgava rafgatdvif vdvfdnklqr akdfgatntf nssqfstdka qdladgvqkl 241 lggnhadvvf ecsgadvcid aavkttkvgg tmvqvgmgkn ytnfpiaevs gkemkligcf 301 rysfgdyrda vnlvatgkvn vkplithkfk fedaakaydy niahggevvk tiifgpe // LOCUS NP_012694 602 aa linear PLN 30-JUN-2025 DEFINITION alpha-glucoside permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_012694 VERSION NP_012694.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181818.1 REFERENCE 1 (residues 1 to 602) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 602) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 602) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 602) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08944. Method: conceptual translation. FEATURES Location/Qualifiers source 1..602 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..602 /product="alpha-glucoside permease" /calculated_mol_wt="67126" Region 72..556 /region_name="SP" /note="MFS transporter, sugar porter (SP) family; TIGR00879" /db_xref="CDD:273317" Site order(111..112,115..116,119,163,213..214,216..218,221,241, 244..245,248,368,371..372,375..377,380,408,412,468..469, 473,477,493,496..497,500..501,504) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:349949" CDS 1..602 /gene="MPH3" /locus_tag="YJR160C" /coded_by="NM_001181818.1:1..1809" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008643 carbohydrate transport [PMID:12210897]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Alpha-glucoside permease; transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication" /db_xref="GeneID:853625" /db_xref="SGD:S000003921" ORIGIN 1 mknlsflinr rkentsdsnv ypgkakshep swiemddqtk kdgldivhve fspdtrapsd 61 snkviteifd atedakeade sergmplata lntypkaaaw sllvsttlim egydtailga 121 fyalpifqrk fgsqndktge weisaswqig ltlcymagei vglqltgpsv dlvgnrytli 181 ialfflaaft filyfcnslg miavgqalcg mpwgcfqclt vsyaseicpl alryylttys 241 nlcwlfgqlf aagimknsqk kyadselgyk lpfalqwilp vplalgiffa pespwwlvkk 301 grfdearrsl rrtlsgkgpe keilvtlevd kikvtidkek rltskegsys dcfedkinrr 361 rtritclcwa gqatcgsili gystyfyeka gvstemsftf siiqyclgic atflswwask 421 yfgrydlyaf glafqtivff iigglgcsst hgskmgsgsl lmavaffynl giapvvfclv 481 sempssrlrt ktiilarnty nvvsiicsvl ilyqlnskkw nwgaksgffw gvlcfctliw 541 avvdlpetag ktfveinelf klgvsarkfk stkvdpfvvk tppkdvshnd pkgdieasia 601 ee // LOCUS NP_012695 383 aa linear PLN 30-JUN-2025 DEFINITION Cos5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012695 VERSION NP_012695.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181819.3 REFERENCE 1 (residues 1 to 383) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 383) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 383) AUTHORS Galibert,F., Alexandraki,D., Baur,A., Boles,E., Chalwatzis,N., Chuat,J.C., Coster,F., Cziepluch,C., De Haan,M., Domdey,H., Durand,P., Entian,K.D., Gatius,M., Goffeau,A., Grivell,L.A., Hennemann,A., Herbert,C.J., Heumann,K., Hilger,F., Hollenberg,C.P., Huang,M.E., Jacq,C., Jauniaux,J.C., Katsoulou,C., Karpfinger-Hartl,L. et al. TITLE Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X JOURNAL EMBO J. 15 (9), 2031-2049 (1996) PUBMED 8641269 REFERENCE 4 (residues 1 to 383) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (12-APR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08945. On Jul 30, 2012 this sequence version replaced NP_012695.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..383 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="X" Protein 1..383 /product="Cos5p" /calculated_mol_wt="45578" Region 73..167 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 261..353 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..383 /gene="COS5" /locus_tag="YJR161C" /coded_by="NM_001181819.3:1..1152" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:25942624]" /experiment="EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:25942624]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /db_xref="GeneID:853626" /db_xref="SGD:S000003922" ORIGIN 1 mkenelknek svdvlsfkql esqkivlpqd lfrssftwfc yeiykslafp iwmllwlpls 61 vwwklsnnci yplivsllvl flgpifvlvi cglsrkrsls kqliqfckev tentpssdph 121 dwevvaanln sylyenkawn tryfffnamg cqeafrttll epfslkkdea akvksfkdsv 181 pyieealgvy frevekqwkl fntekswspv gledvqlpkd ihrskltwfl kriftiyslp 241 lwlaflncic vsqhfclafr ilcpglfflm mvwlfqnmrt tallvkmehk mqflltiine 301 qesgangwde iarkmnrylf ekkawkneef ffegidcewf fshffyrlls akksmwllpl 361 nvelwpyike aqlsrneesl mkk // LOCUS NP_012698 123 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012698 VERSION NP_012698.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179789.1 REFERENCE 1 (residues 1 to 123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 123) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08946. Method: conceptual translation. FEATURES Location/Qualifiers source 1..123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..123 /product="seripauperin PAU16" /calculated_mol_wt="12917" Region 26..118 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..123 /gene="PAU16" /locus_tag="YKL224C" /coded_by="NM_001179789.1:1..372" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole" /db_xref="GeneID:853656" /db_xref="SGD:S000001707" ORIGIN 1 mvkltsiaag vaaiaagvaa apatttlsps dervnlvelg vyvsdirahl aqyylfqaah 61 psetypveia eavfnygdft tmltgipaeq vtrvitgvpw ystrlrpais salskdgiyt 121 ian // LOCUS NP_012700 705 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKL222C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012700 VERSION NP_012700.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179787.1 REFERENCE 1 (residues 1 to 705) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 705) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 705) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 705) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08947. Method: conceptual translation. FEATURES Location/Qualifiers source 1..705 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..705 /product="uncharacterized protein" /calculated_mol_wt="82117" Region 18..59 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(19,23,28..31,33,36,46) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(24,27,34,41,44,52) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 200..463 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..705 /locus_tag="YKL222C" /coded_by="NM_001179787.1:1..2118" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21777356]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0072686 mitotic spindle [PMID:21777356]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine" /db_xref="GeneID:853658" /db_xref="SGD:S000001705" ORIGIN 1 mkntelsqkk kldrqsrrkp akschfcrvr klkcdrvrpf cgscssrnrk qceykentsa 61 medqlrkkyr rcsklemarr ieelesqltk qsqpnihegq nplsnmryls skhnrhilyg 121 ptsyrailat qtdtfakyre eiwqvlklsr nnwkrehhys tlseissiet apphsgspsv 181 ieylceslpn yevlceyltd ffasdfydsy qivhkekvlr dlqdcfvkgp rshktgqhti 241 islnldskkn yykvgvmtai mclashpkev peaievfhkv ltsfvsakvf ytervqflfl 301 rylyinvagl dggdqshcif ihgltidtai hmglnedlrr lylsknhpie eipylerlwl 361 wilftdvkis lstgipvrin ddfvnkvrle nysssgdill ykttlrlrni mkqiharekp 421 pdipliiedl kkftikmfkp ldfylnasnl ngneftelql whatlhmigs lsnlytlthq 481 dfdarifnfs vlaplnslhl cfnvletyfe ldnsklssks lclskkwphl nnalfliyvn 541 afraliqiyt iflqymenkd iqlfiqrnss altysicpgd fegphnkcis lkiafkemen 601 ifdhihqekl kpltqiwqns yyfsiiisme kigrrafnkg mknidegpet endatenslt 661 tilndlegpl edfsenfidd ilgspsaffd taisgwsnfe dffsr // LOCUS NP_012701 473 aa linear PLN 30-JUN-2025 DEFINITION Mch2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012701 VERSION NP_012701.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179786.2 REFERENCE 1 (residues 1 to 473) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 473) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 473) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 473) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08948. On Apr 26, 2011 this sequence version replaced NP_012701.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..473 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..473 /product="Mch2p" /calculated_mol_wt="52126" Region 41..428 /region_name="MFS_MCT_SLC16" /note="Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; cd17352" /db_xref="CDD:340910" Site order(52..53,56..57,60,98,149..150,152..154,157,176, 179..180,183,257,260..261,264..266,269,296,300,350..351, 355,359,375,378..379,382..383,386) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340910" CDS 1..473 /gene="MCH2" /locus_tag="YKL221W" /coded_by="NM_001179786.2:1..1422" /note="Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport" /db_xref="GeneID:853659" /db_xref="SGD:S000001704" ORIGIN 1 mseerhedhh rdvenklnln gkddingnts isievpdggy gwfillafil ynfstwgans 61 gyaiylahyl enntfaggsk ldyasiggla fscglffapv itwlyhifsi qfiiglgilf 121 qgaalllaaf svtlweiylt qgvligfgla fifipsvtli plwfrnkrsl asgigtagsg 181 lggivfnlgm qsilqkrgvk waliaqciic tslstialml trtthqglrq hkrsykfell 241 dydvlsnfav wllfgfvsfa mlgyvvllys lsdftvslgy tskqgsyvsc mvsvgsllgr 301 pivghiadky gsltvgmilh lvmailcwam wipcknlata iafgllvgsi mgtiwptias 361 ivtrivglqk lpgtfgstwi fmaafalvap iiglelrstd tngndyyrta ifvgfayfgv 421 slcqwllrgf iiardeiavr eaysadqnel hlnvklshms kclfrykqlp rrv // LOCUS NP_012702 711 aa linear PLN 30-JUN-2025 DEFINITION ferric/cupric-chelate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012702 VERSION NP_012702.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179785.1 REFERENCE 1 (residues 1 to 711) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 711) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 711) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 711) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08949. Method: conceptual translation. FEATURES Location/Qualifiers source 1..711 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..711 /product="ferric/cupric-chelate reductase" /EC_number="1.16.1.9" /calculated_mol_wt="79941" Region 280..397 /region_name="Ferric_reduct" /note="Ferric reductase like transmembrane component; pfam01794" /db_xref="CDD:426438" Region 435..605 /region_name="NOX_Duox_like_FAD_NADP" /note="NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; cd06186" /db_xref="CDD:99783" Site order(464,479..482,496..498,502..504,547) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(479,481..482) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99783" Region 537..690 /region_name="NAD_binding_6" /note="Ferric reductase NAD binding domain; pfam08030" /db_xref="CDD:429792" Site 542..552 /site_type="other" /note="NAD pyrophosphate binding region [chemical binding]" /db_xref="CDD:99783" Site order(542,546..549,551) /site_type="other" /note="beta-alpha-beta stucture motif" /db_xref="CDD:99783" Site order(574..575,578) /site_type="other" /note="NADP ribose binding motif [chemical binding]" /db_xref="CDD:99783" CDS 1..711 /gene="FRE2" /locus_tag="YKL220C" /coded_by="NM_001179785.1:1..2136" /experiment="EXISTENCE:direct assay:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:31322728]" /experiment="EXISTENCE:direct assay:GO:0000293 ferric-chelate reductase activity [PMID:8164662]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8164662]" /experiment="EXISTENCE:direct assay:GO:0006826 iron ion transport [PMID:8164662]" /experiment="EXISTENCE:direct assay:GO:0015677 copper ion import [PMID:9153234]" /note="Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels" /db_xref="GeneID:853660" /db_xref="SGD:S000001703" ORIGIN 1 mhwtsilsai llfclsgara spaktvirnk vpllvtnact rifqkvtwey tskskrsspv 61 csyepafqsm lyciyetlde kgysnktlek tfstikknca sysdalqnmt nsefydvlnn 121 gtrhmtpyvk gsanltypve mdtqlrkayy halhgfyanl dvgniyggii cayfvaimaf 181 agvlhcmnyt pfktvllkqk lvgyvrgylt lptigskhas dfsyfriftg ylptrlegii 241 ilgylvlhtv flaygyeydp eniifksrrv qvaryvadrs gvlafahfpl ivlfagrnnf 301 leyisgvkyt sfimfhkwlg rmmfldamih gsaytsytva nktwatsknr lywqfgvaal 361 clagtmvffs favfrkyfye aflflhivlg amffyacweh vvslsgiewi ytaiaiwivd 421 riiriikasy fgfpkaslql igddlirltv kkparpwrak pgqyvfvsfl hplyfwqshp 481 ftvldsvskn gelviilkek kgvtrlvkky vcrnggktsm rlaiegpygs sspvnnynnv 541 llltggtglp gpiahaiklg ktsaaagkqs vklviavrgf dvleaykpel mclenlnvql 601 hiyntmevps ltpsdsldis qqdekadekg tvvattleks anplgfdgvv fhcgrpnvke 661 llheaaelsg slsvvccgpp ifvdkvrnet akivldksak aieyfeeyqc w // LOCUS NP_012703 407 aa linear PLN 30-JUN-2025 DEFINITION Cos9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012703 VERSION NP_012703.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179784.1 REFERENCE 1 (residues 1 to 407) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 407) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 407) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08950. Method: conceptual translation. FEATURES Location/Qualifiers source 1..407 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..407 /product="Cos9p" /calculated_mol_wt="48414" Region 109..195 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 289..379 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..407 /gene="COS9" /locus_tag="YKL219W" /coded_by="NM_001179784.1:1..1224" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /db_xref="GeneID:853661" /db_xref="SGD:S000001702" ORIGIN 1 mqivrscnsn nkplipssnw hiairmrgdg vkdrsidvls lkhfesqkvv lpqdlfmdnf 61 twmfyeffkc ftfrtwllll llmwlpgfls qiksinrifp fklcilvscl vgiflpniys 121 fshksvltnq ltqfskeive hapgtdthdw etvaanlnsy fyenkawnte yfffnaaecq 181 kafrkvllep fsvkkdessk iksfgdsvpy ieealqvyst efdkkwklfn tekvwspdnl 241 ehvqlpkkty rykftwvlkr ifnlwlfpaf ilflaciyvs wdkghlfril ccgggfllmv 301 rvfqnmrpfs mhmedkmqfl stiineqesg angwdeiakk mnrylfekkv wtseefffdg 361 idcewffnhf fyrllstkkp mfdrplnvel wpyikeaqlt rkqappv // LOCUS NP_012704 326 aa linear PLN 30-JUN-2025 DEFINITION threo-3-hydroxy-L-aspartate ammonia-lyase SRY1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012704 VERSION NP_012704.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179783.1 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 326) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08951. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..326 /product="threo-3-hydroxy-L-aspartate ammonia-lyase SRY1" /EC_number="4.3.1.16" /calculated_mol_wt="34768" Region 4..319 /region_name="PRK07048" /note="threo-3-hydroxy-L-aspartate ammonia-lyase" /db_xref="CDD:235918" Site order(6..7,10,13..14,45..46,192..193,262,265..266,269, 273..275,306..309) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:107205" Site order(53,80,179..183,304) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:107205" Site 53 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:107205" CDS 1..326 /gene="SRY1" /locus_tag="YKL218C" /coded_by="NM_001179783.1:1..981" /experiment="EXISTENCE:direct assay:GO:0030848 threo-3-hydroxyaspartate ammonia-lyase activity [PMID:12951240]" /experiment="EXISTENCE:direct assay:GO:0042219 modified amino acid catabolic process [PMID:12951240]" /experiment="EXISTENCE:mutant phenotype:GO:0030848 threo-3-hydroxyaspartate ammonia-lyase activity [PMID:12951240]" /experiment="EXISTENCE:mutant phenotype:GO:0042219 modified amino acid catabolic process [PMID:12951240]" /note="3-hydroxyaspartate dehydratase; deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity" /db_xref="GeneID:853662" /db_xref="SGD:S000001701" ORIGIN 1 mivptygdvl dasnrikeyv nktpvltsrm lndrlgaqiy fkgenfqrvg afkfrgamna 61 vsklsdekrs kgviafssgn haqaialsak llnvpativm pedapalkva atagygahii 121 rynrytedre qigrqlaaeh gfalippydh pdviagqgts akelleevgq ldalfvplgg 181 ggllsgsala arslspgcki fgvepeagnd gqqsfrsgsi vhintpktia dgaqtqhlge 241 ytfaiirenv ddiltvsdqe lvkcmhflae rmkvvvepta clgfagallk keelvgkkvg 301 iilsggnvdm kryatlisgk edgpti // LOCUS NP_012705 616 aa linear PLN 30-JUN-2025 DEFINITION monocarboxylate/H+ symporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_012705 VERSION NP_012705.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179782.1 REFERENCE 1 (residues 1 to 616) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 616) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 616) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 616) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08952. Method: conceptual translation. FEATURES Location/Qualifiers source 1..616 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..616 /product="monocarboxylate/H+ symporter" /calculated_mol_wt="69245" Region 129..544 /region_name="2A0112" /note="putative sialic acid transporter; TIGR00891" /db_xref="CDD:273324" CDS 1..616 /gene="JEN1" /locus_tag="YKL217W" /coded_by="NM_001179782.1:1..1851" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17710650]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006849 plasma membrane pyruvate transport [PMID:17710650]" /experiment="EXISTENCE:mutant phenotype:GO:0035879 plasma membrane lactate transport [PMID:10198029|PMID:17710650]" /experiment="EXISTENCE:mutant phenotype:GO:0097079 selenite:proton symporter activity [PMID:20861301]" /experiment="EXISTENCE:mutant phenotype:GO:0097080 plasma membrane selenite transport [PMID:20861301]" /note="Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose" /db_xref="GeneID:853663" /db_xref="SGD:S000001700" ORIGIN 1 msssitdeki sgeqqqpagr klyyntstfa epplvdgegn pinyepevyn pdheklyhnp 61 slpaqsiqdt rddellervy sqdqgveyee deedkpnlsa asiksyaltr ftsllhihef 121 swenvnpipe lrkmtwqnwn yffmgyfawl saawaffcvs vsvaplaely drptkditwg 181 lglvlfvrsa gavifglwtd kssrkwpyit clflfviaql ctpwcdtyek flgvrwitgi 241 amggiygcas ataiedapvk arsflsglff sayamgfifa iifyrafgyf rddgwkilfw 301 fsiflpilli fwrllwpetk yftkvlkark lilsdavkan ggeplpkanf kqkmvsmkrt 361 vqkywllfay lvvllvgpny lthasqdllp tmlraqlgls kdavtvivvv tnigaicggm 421 ifgqfmevtg rrlglliact mggcftypaf mlrsekailg agfmlyfcvf gvwgilpihl 481 aelapadara lvaglsyqlg nlasaaasti etqladrypl erdasgavik edyakvmail 541 tgsvfiftfa cvfvghekfh rdlsspvmkk yinqveeyea dglsisdive qktecasvkm 601 idsnvsktye ehietv // LOCUS NP_012706 314 aa linear PLN 30-JUN-2025 DEFINITION dihydroorotate dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012706 VERSION NP_012706.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179781.1 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 314) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08953. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..314 /product="dihydroorotate dehydrogenase" /EC_number="1.3.98.1" /calculated_mol_wt="34670" Region 4..314 /region_name="PRK02506" /note="dihydroorotate dehydrogenase 1A; Reviewed" /db_xref="CDD:235045" Site order(22,46..47,70,72..74,130,133,135,167,195..197,224,253, 274..275) /site_type="active" /db_xref="CDD:240092" Site order(22,46..47,70,72,130,167,195,224,253,274..275) /site_type="other" /note="FMN binding site [chemical binding]" /db_xref="CDD:240092" Site order(46,70,72..74,130,133,135,196..197) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:240092" Site order(46,133,167) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:240092" Site order(140..141,172..173,175,198,200,202,204,206,208..211, 214,219,226,229,233,266) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:240092" CDS 1..314 /gene="URA1" /locus_tag="YKL216W" /coded_by="NM_001179781.1:1..945" /experiment="EXISTENCE:direct assay:GO:0004152 dihydroorotate dehydrogenase activity [PMID:1511880]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:1409592]" /experiment="EXISTENCE:direct assay:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:10871048]" /experiment="EXISTENCE:mutant phenotype:GO:0004152 dihydroorotate dehydrogenase activity [PMID:4550660]" /experiment="EXISTENCE:mutant phenotype:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:5651325|PMID:4550660]" /note="Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid" /db_xref="GeneID:853664" /db_xref="SGD:S000001699" ORIGIN 1 mtaslttkfl nntyenpfmn asgvhcmttq eldelanska gafitksatt leregnpepr 61 yisvplgsin smglpnegid yylsyvlnrq knypdapaif fsvagmside nlnllrkiqd 121 sefngiteln lscpnvpgkp qvaydfdltk etlekvfaff kkplgvklpp yfdfahfdim 181 akilnefpla yvnsinsign glfidvekes vvvkpkngfg giggeyvkpt alanvrafyt 241 rlrpeikvig tggiksgkda fehllcgasm lqigtelqke gvkiferiek elkdimeakg 301 ytsidqfrgk lnsi // LOCUS NP_012707 1286 aa linear PLN 30-JUN-2025 DEFINITION 5-oxoprolinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012707 VERSION NP_012707.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179780.1 REFERENCE 1 (residues 1 to 1286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1286) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08954. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1286 /product="5-oxoprolinase" /EC_number="3.5.2.9" /calculated_mol_wt="140297" Region 4..1282 /region_name="PLN02666" /note="5-oxoprolinase" /db_xref="CDD:215358" CDS 1..1286 /gene="OXP1" /locus_tag="YKL215C" /coded_by="NM_001179780.1:1..3861" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity [PMID:20402795]" /experiment="EXISTENCE:mutant phenotype:GO:0006749 glutathione metabolic process [PMID:20349993]" /experiment="EXISTENCE:mutant phenotype:GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity [PMID:20402795]" /note="5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853665" /db_xref="SGD:S000001698" ORIGIN 1 mqkgniriai dkggtftdcv gnigtgkqeh dtvikllsvd pknypdaple girrllevle 61 hktiprgipl disnvrslrm gttlatncal erngercafi ttkgfkdsll igdqtrpdif 121 nlnikkvvpl ydtvveider vtledfsedp yftksspneq egilegnsge mvrvikkpde 181 ssvrsilkvl yasgiksiai aflhsytfpd herivgniar eigfshvsls sevspmikfl 241 prahssvada yltpvikkyl nsisaglsha edthiqfmqs dgglvdggkf sglksilsgp 301 aggvigysst cydknnnipl igfdmggtst dvsrygdgrl ehvfetvtag iiiqspqldi 361 htvaaggssi lswknglfrv gpdsaaadpg paayrkggpl titdanlflg rlvpeffpki 421 fgpnedesld letttlkfre ltdvinkdln snltmeevay gfikvanecm arpvraitea 481 kghvvsqhrl vsfggaggqh aiavadslgi dtvlihryss ilsaygifla dvieenqepc 541 sfilgepeti lkvkkrflel sknsiknlls qsfsredivl erylnlryeg tetslmilqk 601 yddqwnfrew fseahkkefg fsfddkriii ddiriraigk sgvrkektvd eqlieishfk 661 kadvskdasf tqkayfdnkw vdtavfkidd lpagtiiegp ailadgtqtn iilpnsqati 721 lnshifikin qkaaktlsks gyeldidpil lsifshrfmd ialqmgtqlr ktsvstnvke 781 rldfscalfd skgnlvanap hvpvhlgsms tcisaqaklw egklkpgdvl itnhpdiggt 841 hlpditvitp sfsstgelif yvasrahhad iggilpgsvp pnskelyeeg taiyselvvk 901 egifqeeliy klfvedpgky pgcsgsrrfs dnisdlkaqv aantkgiqli gsltkeydla 961 tilkymaaiq tnasesikkm lakmvehfgt tkfsgedrld dgsliklqvi irpekeeyif 1021 nfdgtspqvy gnlnapeait nsailyclrc lvgediplnq gclkpltiki pagsllsprs 1081 gaavvggnvl tsqrvtdvil ktfnvmadsq gdcnnftfgt ggnsgnktdk qikgfgyyet 1141 icggsgagad swrgsgwngs davhtnmtnt rmtdtevfer rypvllkefs irrgsggkgk 1201 ytggngvvrd vqfrkavtas ilserrvigp hgikggqdgs rgenlwvrhs tgalinvggk 1261 ntiyaqpgdr fiiktpgggg fgqykd // LOCUS NP_012708 203 aa linear PLN 30-JUN-2025 DEFINITION Yra2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012708 VERSION NP_012708.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179779.1 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 203) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08955. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..203 /product="Yra2p" /calculated_mol_wt="23647" Region 64..137 /region_name="RRM_YRA2" /note="RNA recognition motif in yeast RNA annealing protein YRA2 (Yra2p) and similar proteins; cd12295" /db_xref="CDD:409736" Region 150..>201 /region_name="FoP_duplication" /note="C-terminal duplication domain of Friend of PRMT1; pfam13865" /db_xref="CDD:464005" CDS 1..203 /gene="YRA2" /locus_tag="YKL214C" /coded_by="NM_001179779.1:1..612" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:11390651]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11390651]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:11390651]" /note="Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus" /db_xref="GeneID:853666" /db_xref="SGD:S000001697" ORIGIN 1 mdkafdeiig nshtdsssnh kvtryrrrdl rnelgprlgf apsdaasrsk drlyrereep 61 plpkririsk ipldvsdytl ddmikefgsp ifskifdnke drtciyefed pevlekiver 121 ynghelhnak ieveiyqpqr khsrmnahnr rkqtaqehgr grpgshyrqk pnrvskknkg 181 reknntptsv ealdaelday mkg // LOCUS NP_012709 715 aa linear PLN 30-JUN-2025 DEFINITION Doa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012709 VERSION NP_012709.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179778.1 REFERENCE 1 (residues 1 to 715) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 715) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 715) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 715) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08956. Method: conceptual translation. FEATURES Location/Qualifiers source 1..715 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..715 /product="Doa1p" /calculated_mol_wt="79375" Region 5..288 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(12,29,33,39..40,52..53,71,75,84..85,97..98,113,118, 124,136,159,165,176,178,195,199,205..206,218..219,240, 246..247,259..260,277,281,287..288) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 58..97 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 102..134 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 142..175 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 182..217 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 223..260 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 267..287 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 333..443 /region_name="PFU" /note="PFU (PLAA family ubiquitin binding); pfam09070" /db_xref="CDD:462670" Region 468..712 /region_name="PUL" /note="PUL domain; pfam08324" /db_xref="CDD:462428" CDS 1..715 /gene="DOA1" /locus_tag="YKL213C" /gene_synonym="UFD3; ZZZ4" /coded_by="NM_001179778.1:1..2148" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:16428438|PMID:21070969]" /experiment="EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:23525333]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380]" /experiment="EXISTENCE:mutant phenotype:GO:0010992 ubiquitin recycling [PMID:7615550|PMID:19805280|PMID:18508771]" /experiment="EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:20508643]" /experiment="EXISTENCE:mutant phenotype:GO:0043130 ubiquitin binding [PMID:16428438]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:23525333|PMID:2111732]" /experiment="EXISTENCE:mutant phenotype:GO:0070314 G1 to G0 transition [PMID:12399380]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:21070972|PMID:32118579]" /note="WD-repeat protein involved in Ub-mediated proteolysis; K48-, K29-specific Ub chain binding protein involved in Ub homeostasis; substrate-recruiting adaptor for Cdc48p in mitochondria-associated degradation; inhibits degradation of Ufd2p-dependent substrates; facilitates proteolysis of Cse4p, a centromeric H3-like protein; required for ribophagy; promotes NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon replication stress" /db_xref="GeneID:853667" /db_xref="SGD:S000001696" ORIGIN 1 mgyqlsatlk ghdqdvrdvv avddskvasv srdgtvrlws kddqwlgtvv ytgqgflnsv 61 cydsekelll fggkdtming vplfatsged plytlighqg nvcslsfqdg vvisgswdkt 121 akvwkegslv ynlqahnasv wdakvvsfse nkfltasadk tiklwqndkv iktfsgihnd 181 vvrhlavvdd ghfiscsndg liklvdmhtg dvlrtyeghe sfvycikllp ngdivscged 241 rtvriwsken gslkqvitlp aisiwsvdcm sngdiivgss dnlvrifsqe ksrwasedei 301 nelstqveks tissktiefd esklspyeil qspgrkegqi vvvkspqgti eahqfsnssw 361 kkvgdvvgag atgndkkief egktydyvfd vdiedgkppl klpinvsdnp ytaadnflar 421 yelpmsyrdq vvqfilkntn gisldqpndn asssavspsk tsvmkvlpvk qylimenynp 481 dtifngivki nsnektfdde ilaqiggalh dideswelll sfantirsnw eiktpaydiv 541 rlivkklpys sdikdyieeg lgnknitltm ltvrilvncf nnenwgvkll esnqvyksif 601 etidtefsqa sakqsqnlai avstlifnys alvtkgnsdl ellpivadai ntkygpleey 661 qeceeaayrl tvaygnlatv eptlrqfans vtwlanikrs ygnvprfkdi fddls // LOCUS NP_012710 623 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol-3-phosphatase SAC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012710 VERSION NP_012710.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179777.1 REFERENCE 1 (residues 1 to 623) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 623) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 623) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 623) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08957. Method: conceptual translation. FEATURES Location/Qualifiers source 1..623 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..623 /product="phosphatidylinositol-3-phosphatase SAC1" /EC_number="3.1.3.64" /calculated_mol_wt="70994" Region 3..578 /region_name="COG5329" /note="Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]" /db_xref="CDD:227637" CDS 1..623 /gene="SAC1" /locus_tag="YKL212W" /gene_synonym="RSD1" /coded_by="NM_001179777.1:1..1872" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:15657391|PMID:8314848]" /experiment="EXISTENCE:direct assay:GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity [PMID:10625610]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11514624|PMID:8314848|PMID:15657391]" /experiment="EXISTENCE:direct assay:GO:0005797 Golgi medial cisterna [PMID:22553352]" /experiment="EXISTENCE:direct assay:GO:0017059 serine palmitoyltransferase complex [PMID:20182505]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:30785834]" /experiment="EXISTENCE:direct assay:GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity [PMID:10625610]" /experiment="EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10625610]" /experiment="EXISTENCE:direct assay:GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity [PMID:10625610]" /experiment="EXISTENCE:genetic interaction:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10625610]" /experiment="EXISTENCE:mutant phenotype:GO:0000139 Golgi membrane [PMID:15657391]" /experiment="EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:11792713|PMID:15657391|PMID:11514624]" /experiment="EXISTENCE:mutant phenotype:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10625610|PMID:22553352]" /experiment="EXISTENCE:mutant phenotype:GO:0061909 autophagosome-lysosome fusion [PMID:32693712]" /experiment="EXISTENCE:mutant phenotype:GO:0072517 host cell viral assembly compartment [PMID:32269127]" /note="Phosphatidylinositol phosphate phosphatase; role in early and medial Golgi PtdIns4P hydrolysis; regulated by Vps74p interaction; ER localized transmembrane protein which cycles through the Golgi; role in protein trafficking, processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis by modulating PtdIns(4)P metabolism; PtdIns4P PPase activity is crucial for autophagosome-vacuole fusion during autophagy; human homolog SACM1L complements autophagy defects of the null" /db_xref="GeneID:853668" /db_xref="SGD:S000001695" ORIGIN 1 mtgpivyvqn adgiffklae gkgtndavih lanqdqgvrv lgaeefpvqg evvkiaslmg 61 fiklklnrya iiantveetg rfnghvfyrv lqhsivstkf nsridseeae yikllelhlk 121 nstfyfsyty dltnslqrne kvgpaaswkt aderffwnhy ltedlrnfah qdpridsfiq 181 pviygyaktv davlnatpiv lglitrrsif ragtryfrrg vdkdgnvgnf neteqillae 241 npesekihvf sflqtrgsvp iywaeinnlk ykpnlvlgen sldatkkhfd qqkelygdny 301 lvnlvnqkgh elpvkegyes vvhalndpki hyvyfdfhhe crkmqwhrvk llidhleklg 361 lsnedffhkv idsngntvei vneqhsvvrt ncmdcldrtn vvqsvlaqwv lqkefesadv 421 vatgstwedn aplltsyqnl wadnadavsv aysgtgalkt dftrtgkrtr lgafndflns 481 asryyqnnwt dgprqdsydl flggfrphta sikspfpdrr pvyiqlipmi icaaltvlga 541 tiffpkdrft ssknllyfag asivlalstk fmfkngiqfv nwpklvdvgf lvvhqthdke 601 qqfkglkyaq spkfskpdpl krd // LOCUS NP_012711 484 aa linear PLN 30-JUN-2025 DEFINITION bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012711 VERSION NP_012711.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179776.1 REFERENCE 1 (residues 1 to 484) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 484) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 484) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 484) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08958. Method: conceptual translation. FEATURES Location/Qualifiers source 1..484 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..484 /product="bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase" /EC_number="4.1.1.48" /EC_number="4.1.3.27" /calculated_mol_wt="53358" Region 14..203 /region_name="PabA" /note="Anthranilate/para-aminobenzoate synthase component II (glutamine amidotransferase) [Amino acid transport and metabolism, Coenzyme transport and metabolism]; COG0512" /db_xref="CDD:440278" Region 217..481 /region_name="IGPS" /note="Indole-3-glycerol phosphate synthase; pfam00218" /db_xref="CDD:395163" Site order(273,275,278..280,314,343,345,366,392,413,415,417, 444..445,466..467) /site_type="active" /db_xref="CDD:238203" Site order(273,275,343,392,413) /site_type="other" /note="ribulose/triose binding site [chemical binding]" /db_xref="CDD:238203" Site order(275,445,466..467) /site_type="other" /note="phosphate binding site [ion binding]" /db_xref="CDD:238203" Site order(279,314,415,417) /site_type="other" /note="substrate (anthranilate) binding pocket [chemical binding]" /db_xref="CDD:238203" Site order(314,343,345,366,417) /site_type="other" /note="product (indole) binding pocket [chemical binding]" /db_xref="CDD:238203" CDS 1..484 /gene="TRP3" /locus_tag="YKL211C" /coded_by="NM_001179776.1:1..1455" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004049 anthranilate synthase activity [PMID:3881257]" /experiment="EXISTENCE:genetic interaction:GO:0004425 indole-3-glycerol-phosphate synthase activity [PMID:6323449]" /experiment="EXISTENCE:mutant phenotype:GO:0000162 L-tryptophan biosynthetic process [PMID:10790693]" /experiment="EXISTENCE:mutant phenotype:GO:0004425 indole-3-glycerol-phosphate synthase activity [PMID:3881257]" /experiment="EXISTENCE:physical interaction:GO:0005950 anthranilate synthase complex [PMID:3881257]" /note="Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p" /db_xref="GeneID:853669" /db_xref="SGD:S000001694" ORIGIN 1 msvhaatnpi nkhvvlidny dsftwnvyey lcqegakvsv yrndaitvpe iaalnpdtll 61 ispgpghpkt dsgisrdcir yftgkipvfg icmgqqcmfd vfggevayag eivhgktspi 121 shdncgifkn vpqgiavtry hslagtessl psclkvtast engiimgvrh kkytvegvqf 181 hpesilteeg hlmirnilnv sggtweenks spsnsildri yarrkidvne qskipgftfq 241 dlqsnydlgl applqdfytv lssshkravv laevkrasps kgpiclkava aeqalkyaea 301 gasaisvlte phwfhgslqd lvnvrkildl kfppkerpcv lrkefifsky qilearlaga 361 dtvllivkml sqpllkelys yskdlnmepl vevnskeelq raleigakvv gvnnrdlhsf 421 nvdlnttsnl vesipkdvll ialsgittrd daekykkegv hgflvgealm kstdvkkfih 481 elce // LOCUS NP_012712 1024 aa linear PLN 30-JUN-2025 DEFINITION E1 ubiquitin-activating protein UBA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012712 VERSION NP_012712.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179775.1 REFERENCE 1 (residues 1 to 1024) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1024) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1024) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1024) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1024) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1024) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1024) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08959. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1024 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1024 /product="E1 ubiquitin-activating protein UBA1" /EC_number="6.2.1.45" /calculated_mol_wt="114136" Region 13..1023 /region_name="Ube1" /note="ubiquitin-activating enzyme E1; TIGR01408" /db_xref="CDD:273603" CDS 1..1024 /gene="UBA1" /locus_tag="YKL210W" /coded_by="NM_001179775.1:1..3075" /experiment="EXISTENCE:direct assay:GO:0004839 ubiquitin activating enzyme activity [PMID:1989885]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:7629121]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:7629121]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:1989885]" /note="Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853670" /db_xref="SGD:S000001693" ORIGIN 1 mssnnsglsa ageideslys rqlyvlgkea mlkmqtsnvl ilglkglgve iaknvvlagv 61 ksmtvfdpep vqladlstqf fltekdigqk rgdvtrakla elnayvpvnv ldslddvtql 121 sqfqvvvatd tvsledkvki nefchssgir fissetrglf gntfvdlgde ftvldptgee 181 prtgmvsdie pdgtvtmldd nrhgledgnf vrfsevegld klndgtlfkv evlgpfafri 241 gsvkeygeyk kggiftevkv prkisfkslk qqlsnpefvf sdfakfdraa qlhlgfqalh 301 qfavrhngel prtmndedan eliklvtdls vqqpevlgeg vdvnedlike lsyqargdip 361 gvvaffgglv aqevlkacsg kftplkqfmy fdsleslpdp knfprnektt qpvnsrydnq 421 iavfgldfqk kianskvflv gsgaigceml knwallglgs gsdgyivvtd ndsieksnln 481 rqflfrpkdv gknksevaae avcamnpdlk gkinakidkv gpeteeifnd sfwesldfvt 541 naldnvdart yvdrrcvfyr kpllesgtlg tkgntqviip rltesysssr dppeksiplc 601 tlrsfpnkid htiawakslf qgyftdsaen vnmyltqpnf veqtlkqsgd vkgvlesisd 661 slsskphnfe dcikwarlef ekkfnhdikq llfnfpkdak tsngepfwsg akraptplef 721 diynndhfhf vvagaslray nygiksddsn skpnvdeyks vidhmiipef tpnanlkiqv 781 ndddpdpnan aangsdeidq lvsslpdpst lagfklepvd fekdddtnhh iefitacsnc 841 raqnyfieta drqktkfiag riipaiattt slvtglvnle lyklidnktd ieqykngfvn 901 lalpffgfse piaspkgeyn nkkydkiwdr fdikgdikls dliehfekde gleitmlsyg 961 vsllyasffp pkklkerlnl pitqlvklvt kkdipahvst mileicaddk egedvevpfi 1021 tihl // LOCUS NP_012713 1290 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette a-factor transporter STE6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012713 VERSION NP_012713.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179774.1 REFERENCE 1 (residues 1 to 1290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1290) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08960. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1290 /product="ATP-binding cassette a-factor transporter STE6" /EC_number="7.4.2.7" /calculated_mol_wt="144635" Region 1..592 /region_name="MdlB" /note="ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; COG1132" /db_xref="CDD:440747" Region 702..1290 /region_name="MdlB" /note="ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; COG1132" /db_xref="CDD:440747" CDS 1..1290 /gene="STE6" /locus_tag="YKL209C" /coded_by="NM_001179774.1:1..3873" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8045256]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:7679674]" /experiment="EXISTENCE:direct assay:GO:0015440 ABC-type peptide transporter activity [PMID:8626301|PMID:11389139]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:7679674|PMID:12374868]" /experiment="EXISTENCE:mutant phenotype:GO:0000770 peptide pheromone export [PMID:2569166]" /experiment="EXISTENCE:mutant phenotype:GO:0015440 ABC-type peptide transporter activity [PMID:11389139|PMID:8626301]" /note="Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; human homolog ABCB1 mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell" /db_xref="GeneID:853671" /db_xref="SGD:S000001692" ORIGIN 1 mnflsfkttk hyhifryvni rndyrllmim iigtvatglv paitsiltgr vfdllsvfva 61 ngshqglysq lvqrsmavma lgaasvpvmw lsltswmhig erqgfrirsq ileayleekp 121 mewydnnekl lgdftqinrc veelrsssae asaitfqnlv aicallgtsf yyswsltlii 181 lcsspiitff avvfsrmihv ysekensets kaaqlltwsm naaqlvrlyc tqrlerkkfk 241 eiilncntff ikscffvaan agilrfltlt mfvqgfwfgs amikkgklni ndvitcfhsc 301 imlgstlnnt lhqivvlqkg gvamekimtl lkdgskrnpl nktvahqfpl dyatsdltfa 361 nvsfsypsrp seavlknvsl nfsagqftfi vgksgsgkst lsnlllrfyd gyngsising 421 hniqtidqkl lienitvveq rctlfndtlr knillgstds vrnadcstne nrhlikdacq 481 malldrfild lpdgletlig tggvtlsggq qqrvaiaraf irdtpilfld eavsaldivh 541 rnllmkairh wrkgkttiil thelsqiesd dylylmkege vvesgtqsel ladptttfst 601 wyhlqndysd aktivdtete eksihtvesf nsqletpklg sclsnlgyde tdqlsfyeai 661 yqkrsnvrtr rvkveeenig yalkqqknte sstgpqllsi iqiikrmiks irykkililg 721 llcsliagat npvfsytfsf llegivpstd gktgsshyla kwsllvlgva aadgifnfak 781 gflldccsey wvmdlrnevm ekltrknmdw fsgennkase isalvlndlr dlrslvsefl 841 samtsfvtvs tigliwalvs gwklslvcis mfpliiifsa iyggilqkce tdyktsvaql 901 enclyqivtn iktikclqae fhfqltyhdl kikmqqiask raiatgfgis mtnmivmciq 961 aiiyyyglkl vmiheytske mfttftlllf timsctslvs qipdisrgqr aaswiyrild 1021 ekhntleven nnartvgiag htyhgkekkp ivsiqnltfa ypsaptafvy knmnfdmfcg 1081 qtlgiigesg tgkstlvlll tklyncevgk ikidgtdvnd wnltslrkei svveqkpllf 1141 ngtirdnlty glqdeileie mydalkyvgi hdfvisspqg ldtridttll sggqaqrlci 1201 arallrkski lildectsal dsvsssiine ivkkgppall tmvithseqm mrscnsiavl 1261 kdgkvvergn fdtlynnrge lfqivsnqss // LOCUS NP_012714 271 aa linear PLN 30-JUN-2025 DEFINITION Cbt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012714 VERSION NP_012714.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179773.1 REFERENCE 1 (residues 1 to 271) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 271) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 271) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 271) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08961. Method: conceptual translation. FEATURES Location/Qualifiers source 1..271 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..271 /product="Cbt1p" /calculated_mol_wt="31026" CDS 1..271 /gene="CBT1" /locus_tag="YKL208W" /gene_synonym="SOC1" /coded_by="NM_001179773.1:1..816" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:9339340]" /experiment="EXISTENCE:direct assay:GO:0017004 cytochrome complex assembly [PMID:9339340]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:9339340|PMID:16118200]" /experiment="EXISTENCE:mutant phenotype:GO:0017004 cytochrome complex assembly [PMID:9339340]" /experiment="EXISTENCE:mutant phenotype:GO:0048255 mRNA stabilization [PMID:16118200]" /note="Protein involved in 5' RNA end processing; substrates include mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p" /db_xref="GeneID:853673" /db_xref="SGD:S000001691" ORIGIN 1 mvsygshsse vskvlktpkf vlrygnvssk qrfalkrkin yklreskyqe ylneyntfvl 61 ydwensgags lvdssynlps lwkefitegi skgaindklp tvfmkrkltn salghclgld 121 fltdpseseh eyrcmfqtvq dipslsqlil fnsmpnvpvr lklhtigini nfgckrslis 181 nggdqdtems eavsyiqpll eessrmyrnl nywkllkiar nnkkdepldq striksqvkl 241 llsqlatnri tspsvtdhgg hnwliftrrr l // LOCUS NP_012715 253 aa linear PLN 30-JUN-2025 DEFINITION ER membrane complex subunit EMC3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012715 VERSION NP_012715.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179772.1 REFERENCE 1 (residues 1 to 253) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 253) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 253) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 253) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08962. On May 22, 2006 this sequence version replaced NP_012715.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..253 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..253 /product="ER membrane complex subunit EMC3" /calculated_mol_wt="28221" Region 2..194 /region_name="EMC3_TMCO1" /note="Integral membrane protein EMC3/TMCO1-like; pfam01956" /db_xref="CDD:396507" CDS 1..253 /gene="EMC3" /locus_tag="YKL207W" /gene_synonym="AIM27" /coded_by="NM_001179772.1:1..762" /experiment="EXISTENCE:direct assay:GO:0072546 EMC complex [PMID:19325107]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]" /note="Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response; homologous to worm Y62E10A.10/EMC-3, fly CG6750, human TMEM111" /db_xref="GeneID:853628" /db_xref="SGD:S000001690" ORIGIN 1 mllddqlkyw vllpisivmv ltgvlkqyim tlitgssane aqprvkltew qylqwaqlli 61 gnggnlssda faakkeflvk dlteerhlak akqqdgsqag evpnpfndps msnammnmak 121 gnmasfipqt iimwwvnhff agfilmqlpf pltakfkeml qtgiicqdld vrwvssiswy 181 fisvlglnpv ynliglndqd mgiqagiggp qgpqgppqsq vdkamhaman dltiiqhetc 241 ldnveqrvlk qym // LOCUS NP_012716 267 aa linear PLN 30-JUN-2025 DEFINITION Add66p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012716 VERSION NP_012716.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179771.1 REFERENCE 1 (residues 1 to 267) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 267) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 267) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 267) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08963. Method: conceptual translation. FEATURES Location/Qualifiers source 1..267 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..267 /product="Add66p" /calculated_mol_wt="30608" Region 4..>127 /region_name="PAC2" /note="PAC2 family; cl42033" /db_xref="CDD:477913" CDS 1..267 /gene="ADD66" /locus_tag="YKL206C" /gene_synonym="PBA2; POC2" /coded_by="NM_001179771.1:1..804" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:17634286]" /experiment="EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:17431397]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:17634286]" /note="Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly" /db_xref="GeneID:853629" /db_xref="SGD:S000001689" ORIGIN 1 msclvlplvs vgnipqlsid wllnsqanew eylealdsky lvefvgpldr pedgsdslyk 61 dadmkyssal evfynkkrgl faiqqrtplv svnylnnfiv eiilpflsky niseiciwds 121 lyamedengv ivrpqevysl gefyfddeae llsnlhlndq esmvnnwlhf tptsfqdkis 181 vdqpifkilf qilnasqrpk alrsikycsc lanegdnsld sqqflqwiis qkviknappi 241 vkfvrpiswq gaygmadard kfvdlyn // LOCUS NP_012717 1100 aa linear PLN 30-JUN-2025 DEFINITION Ran GTPase-binding protein LOS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012717 VERSION NP_012717.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179770.1 REFERENCE 1 (residues 1 to 1100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1100) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08964. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1100 /product="Ran GTPase-binding protein LOS1" /calculated_mol_wt="126689" Region 2..>379 /region_name="CRM1" /note="Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]; COG5101" /db_xref="CDD:227432" Region 102..274 /region_name="Xpo1" /note="Exportin 1-like protein; pfam08389" /db_xref="CDD:462459" Region 365..1097 /region_name="Exportin-T" /note="pfam19282" /db_xref="CDD:437114" CDS 1..1100 /gene="LOS1" /locus_tag="YKL205W" /coded_by="NM_001179770.1:1..3303" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18045534]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0016363 nuclear matrix [PMID:8366091]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:9774653]" /experiment="EXISTENCE:genetic interaction:GO:0071528 tRNA re-export from nucleus [PMID:20032305]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:9802895]" /note="Nuclear pore protein; involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm; deletion mutation extends replicative lifespan, as does exclusion of Los1p from the nucleus in response to caloric restriction" /db_xref="GeneID:853630" /db_xref="SGD:S000001688" ORIGIN 1 mleriqqlvn avndprsdva tkrqaielln gikssenale ifislvinen sndllkfygl 61 stlielmteg vnanpnglnl vkfeitkwlk fqvlgnkqtk lpdflmnkis evlttlfmlm 121 ysdcngnqwn sffddlmslf qvdsaisnts pstdgnillg leffnklclm inseiadqsf 181 irskesqlkn nnikdwmrdn dimklsnvwf qclkldeqiv sqcpglinst ldcigsfisw 241 idinliidan nyylqliykf lnlketkisc yncilaiisk kmkpmdklaf lnminltnel 301 tyyhqaismn pqiitfdnle vwesltklit sfgieftiii eqvnddqkld tlykqsvisn 361 vdsillekii pillefmnne fdsitaktfp fwsnylaflk kykasspnfv plhkdfldnf 421 qqicfkrmkf sddevtqddf eefnetvrfk lknfqeiivv idpslflnni sqeisanlmn 481 ckneswqife ltiyqifnls ectknnyfgl nkneimtsqp sltlvrflne llmmkdflla 541 idneqiqilf melivknynf ifstsantan atdddekyll ilnifmssfa mfnkrenvrl 601 rswylftrfl kltrinlkki lfanknlvne itnkispllh ikvtsinaqg tddndtifdn 661 qlyifegigf iitlnnssqe ltaatantpi dydildqilt plftqlegci tqgaspvvil 721 echhilmaig tlarglhigl vpenqvnnmv vnkklindsl ihkfsniaev ilvtfsffnk 781 fenirdasrf tfarlipils nkilpfinkl ielilsstdl kswemidflg flsqlihmfh 841 tdtdcyqlfn qlltplinkv hsiieeideq hdqqsssnkp idtavtatsv nknivvtdsy 901 rdkillkkay ctflqsftnn svtsillsdi nrailpviln dlvtytpqei qetsmmkvsl 961 nvlcnfikcf gngtcldndd inkdpnlkid glneyfimkc vpiifeipfn piykfnikeg 1021 nfktmaydla rllrelfivs snpttnenec vkyltqiylp qiqlpqelti qlvnmlttmg 1081 qkqfekwfvd nfisvlkqgq // LOCUS NP_012718 632 aa linear PLN 30-JUN-2025 DEFINITION Eap1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012718 VERSION NP_012718.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179769.1 REFERENCE 1 (residues 1 to 632) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 632) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 632) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 632) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08965. Method: conceptual translation. FEATURES Location/Qualifiers source 1..632 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..632 /product="Eap1p" /calculated_mol_wt="69631" Region 103..252 /region_name="Eap1" /note="eIF4E-associated protein; pfam20566" /db_xref="CDD:466715" Region <555..622 /region_name="PABP-1234" /note="polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628" /db_xref="CDD:130689" CDS 1..632 /gene="EAP1" /locus_tag="YKL204W" /coded_by="NM_001179769.1:1..1899" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0008190 eukaryotic initiation factor 4E binding [PMID:10848587]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:10848587]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:22890846]" /experiment="EXISTENCE:mutant phenotype:GO:0006402 mRNA catabolic process [PMID:22890846]" /experiment="EXISTENCE:mutant phenotype:GO:0017148 negative regulation of translation [PMID:10848587]" /note="eIF4E-associated protein, competes with eIF4G for binding to eIF4E; accelerates mRNA degradation by promoting decapping, facilitated by interaction with eIF4E; essential for Puf5p mediated repression; associates with Puf5p and Dhh1p; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade" /db_xref="GeneID:853631" /db_xref="SGD:S000001687" ORIGIN 1 melndpsiis ssqfsgelsd sdtaaathks qqaisnlfqk lakkgreekp igsvesstds 61 snisvatsgn nkesnkkknk ktamlnfssl tdpitnykpm dlqyktyays mnelyhlkps 121 lasasyeedp liselvrslp krkfwrlrmg ppdqkhannh hfngnngggs wkagykngkn 181 derrmsrtkn mqggkrrsqq ddeekkidqe mlemdknlql ggdvghsiad fedwkakmke 241 lelkklsksk gisnstaiap resashetpt dlrpviprgp ssitdflnlk rqdkkeessq 301 qtpgipvgqp slsktsieqv neletnsdlg kssssrfssf fnksatslps ldnnnqvpss 361 nvsvvnndgn stphqsgsrl msffkesrss tpnaesqlls asdkdngkmq tlpqfqqqpq 421 qmqpmaftqh ppnnnaffng llnkgksets tppppppgli ahqgpqfpvm gvppnfpqrm 481 mppppglvqf qkdskdvnkk edrqlrqnkn pngtrnskgk qeetatpdlp qqqymppppp 541 pgffpmhpnf pngpmpplpq gfpippngml pvtgqqpqpp ypnmmlqgnf ppnfqqgfgs 601 nspmpipsii nangknvtnq lppglnskkn ik // LOCUS NP_012719 2474 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol kinase-related protein kinase TOR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012719 VERSION NP_012719.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179768.1 REFERENCE 1 (residues 1 to 2474) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2474) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2474) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 2474) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08966. On Feb 23, 2004 this sequence version replaced NP_012719.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2474 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..2474 /product="phosphatidylinositol kinase-related protein kinase TOR2" /EC_number="2.7.1.67" /EC_number="2.7.11.1" /calculated_mol_wt="281438" Region 290..2474 /region_name="TEL1" /note="Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032" /db_xref="CDD:227365" Region 599..620 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(612..613,616,619..620,660,663..664,667,695..696,699, 702..703,706,740..741,744,747..748,778..779,782,785..786) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 642..667 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 677..707 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 715..748 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 758..787 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 801..828 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 843..873 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..2474 /gene="TOR2" /locus_tag="YKL203C" /gene_synonym="DRR2" /coded_by="NM_001179768.1:1..7425" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:8846782]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:22307609|PMID:16055732]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10973982]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:9461583]" /experiment="EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:9461583]" /experiment="EXISTENCE:genetic interaction:GO:0035025 positive regulation of Rho protein signal transduction [PMID:9038344]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:16055732]" /experiment="EXISTENCE:mutant phenotype:GO:0007010 cytoskeleton organization [PMID:9475724]" /experiment="EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]" /experiment="EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:8186460|PMID:12719473]" /experiment="EXISTENCE:mutant phenotype:GO:0035025 positive regulation of Rho protein signal transduction [PMID:9038344]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:10198052]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:14593073]" /experiment="EXISTENCE:mutant phenotype:GO:1905356 regulation of snRNA pseudouridine synthesis [PMID:27268497]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12631735]" /experiment="EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]" /note="PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates homeostasis of plasma membrane (PM) tension and cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; PM retention is dependent on Avo3p; malonyl-CoA is a direct ATP-competitive inhibitor of TORC1; TOR2 has a paralog, TOR1, that arose from the whole genome duplication" /db_xref="GeneID:853632" /db_xref="SGD:S000001686" ORIGIN 1 mnkyinkytt ppnllslrqr aegkhrtrkk lthkshshdd emsttsntds nhngpndsgr 61 vitgsaghig kisfvdseld ttfstlnlif dklksdvpqe rasganelst tltslarevs 121 aeqfqrfsns lnnkifelih gftssekigg ilavdtlisf ylsteelpnq tsrlanylrv 181 lipssdievm rlaantlgrl tvpggtltsd fvefevrtci dwltltadnn sssskleyrr 241 haalliikal adnspyllyp yvnsildniw vplrdaklii rldaavalgk cltiiqdrdp 301 algkqwfqrl fqgcthglsl ntndsvhatl lvfrellslk apylrdkydd iykstmkyke 361 ykfdvirrev yailpllaaf dpaiftkkyl drimvhylry lknidmnaan nsdkpfilvs 421 igdiafevgs sispymtlil dnireglrtk fkvrkqfekd lfycigklac algpafakhl 481 nkdllnlmln cpmsdhmqet lmilnekips lestvnsril nllsislsge kfiqsnqydf 541 nnqfsiekar ksrnqsfmkk tgesndditd aqiliqcfkm lqlihhqysl tefvrlitis 601 yiehedssvr klaaltscdl fikddickqt svhalhsvse vlskllmiai tdpvaeirle 661 ilqhlgsnfd pqlaqpdnlr llfmalndei fgiqleaiki igrlssvnpa yvvpslrktl 721 lelltqlkfs nmpkkkeesa tllctlinss devakpyidp ildvilpkcq dassavasta 781 lkvlgelsvv ggkemtrylk elmpliintf qdqsnsfkrd aalttlgqla assgyvvgpl 841 ldypellgil inilktennp hirrgtvrli gilgaldpyk hreievtsns kssveqnaps 901 idiallmqgv spsndeyypt vvihnlmkil ndpslsihht aaiqaimhif qnlglrcvsf 961 ldqiipgiil vmrscppsql dfyfqqlgsl isivkqhirp hvekiygvir effpiiklqi 1021 tiisviesis kalegefkrf vpetltffld ilendqsnkr ivpirilksl vtfgpnledy 1081 shlimpivvr mteysagslk kisiitlgrl akninlsems srivqalvri lnngdreltk 1141 atmntlslll lqlgtdfvvf vpvinkallr nriqhsvydq lvnkllnnec lptniifdke 1201 nevperknye demqvtklpv nqnilknawy csqqktkedw qewirrlsiq llkespsacl 1261 rscsslvsvy yplarelfna sfsscwvelq tsyqedliqa lckalsssen ppeiyqmlln 1321 lvefmehddk plpipihtlg kyaqkchafa kalhykevef leepknstie alisinnqlh 1381 qtdsaigilk haqqhnelql ketwyeklqr wedalaayne keaagedsve vmmgklrsly 1441 algeweelsk lasekwgtak pevkkamapl aagaawgleq wdeiaqytsv mksqspdkef 1501 ydailclhrn nfkkaevhif nardllvtel salvnesynr aynvvvraqi iaeleeiiky 1561 kklpqnsdkr ltmretwntr llgcqknidv wqrilrvrsl vikpkedaqv rikfanlcrk 1621 sgrmalakkv lntlleetdd pdhpntakas ppvvyaqlky lwatglqdea lkqlinftsr 1681 mahdlgldpn nmiaqsvpqq skrvprhved ytkllarcfl kqgewrvclq pkwrlsnpds 1741 ilgsyllath fdntwykawh nwalanfevi smltsvskkk qegsdassvt dinefdngmi 1801 gvntfdakev hyssnlihrh vipaikgffh sislsesssl qdalrlltlw ftfggipeat 1861 qamhegfnli qigtwlevlp qlisrihqpn qivsrsllsl lsdlgkahpq alvyplmvai 1921 kseslsrqka alsiiekmri hspvlvdqae lvshelirma vlwheqwyeg lddasrqffg 1981 ehntekmfaa leplyemlkr gpetlreisf qnsfgrdlnd ayewlmnykk skdvsnlnqa 2041 wdiyynvfrk igkqlpqlqt lelqhvspkl lsahdlelav pgtrasggkp ivkiskfepv 2101 fsvisskqrp rkfcikgsdg kdykyvlkgh edirqdslvm qlfglvntll qndaecfrrh 2161 ldiqqypaip lspksgllgw vpnsdtfhvl irehreakki plniehwvml qmapdydnlt 2221 llqkvevfty alnntegqdl ykvlwlksrs setwlerrtt ytrslavmsm tgyilglgdr 2281 hpsnlmldri tgkvihidfg dcfeaailre kfpekvpfrl trmltyamev sgiegsfrit 2341 cenvmkvlrd nkgslmaile afafdplinw gfdlptkkie eetgiqlpvm nanellsnga 2401 iteeevqrve nehknairna ramlvlkrit dkltgndirr fndldvpeqv dkliqqatsv 2461 enlcqhyigw cpfw // LOCUS NP_012721 1178 aa linear PLN 30-JUN-2025 DEFINITION Mnn4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012721 VERSION NP_012721.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179766.1 REFERENCE 1 (residues 1 to 1178) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1178) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1178) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1178) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08967. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1178 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1178 /product="Mnn4p" /calculated_mol_wt="139250" Region 490..746 /region_name="LicD" /note="LicD family; pfam04991" /db_xref="CDD:428243" CDS 1..1178 /gene="MNN4" /locus_tag="YKL201C" /gene_synonym="YKL200C" /coded_by="NM_001179766.1:1..3537" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:30842360]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9023541]" /experiment="EXISTENCE:mutant phenotype:GO:0006493 protein O-linked glycosylation [PMID:9813355]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:9459307]" /note="Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; may also function as a mannosylphosphate transferase; expression increases in late-logarithmic and stationary growth phases; coding sequence contains length polymorphisms in different strains; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication" /db_xref="GeneID:853634" /db_xref="SGD:S000001684" ORIGIN 1 mlqrissklh rrflsgllrv khyplrrill plillqiiii tfiwsnspqr nglgrdadyl 61 lpnyneldsd ddswysilts sfkndrkiqf aktlyenlkf gtnpkwvney tlqndllsvk 121 mgprkgskle svdelkfydf dprltwsvvl nhlqnndadq peklpfswyd wttfhelnkl 181 isidktvlpc nflfqsafdk esleaietel geplflyerp kyaqklwyka arnqdrikds 241 kelkkhcskl ftpdghgspk glrfntqfqi kelydkvrpe vyqlqarnyi lttqshplsi 301 siiesdnsty qvplqteksk nlvqsgllqe yindninstn krkknkqdve fnhnrlfqef 361 vnndqvnsly kleieetdkf tfdkdlvyls psdfkfdask kieeleeqkk lypdkfsahn 421 enylnslkns vktspalqrk ffyeagavkq ykgmgfhrdk rffnvdtlin dkqeyqarln 481 smirtfqkft kangiiswls hgtlygylyn gmafpwdndf dlqmpikhlq llsqyfnqsl 541 iledprqgng ryfldvsdsl tvringngkn nidarfidvd tglyiditgl astsapsrdy 601 lnsyieerlq eehldinnip esngetatlp dkvddglvnm atlnitelrd yitsdenknh 661 krvptdtdlk dllkkeleel pksktienkl npkqryflne klklyncrnn hfnsfeelsp 721 lintvfhgvp aliphrhtyc lhneyhvpdr yafdayknta ylpefrfwfd ydglkkcsni 781 nswypnipsi nswnpnllke isstkfeskl fdsnkvseys fknlsmddvr liyknipkag 841 fievftnlyn sfnvtayrqk eleiqycqnl tfiekkkllh qlrinvapkl sspakdpflf 901 gyekamwkdl sksmnqttld qvtkivheey vgkiidlses lkyrnfslfn itfdetgttl 961 ddntedytpa ntvevnpvdf ksnlnfssns fldlnsygld lfaptlsdvn rkgiqmfdkd 1021 piivyedyay aklleerkrr ekkkkeeeek kkkeeeekkk keeeekkkke eeekkkkeee 1081 ekkkkeeeek kkqeeeekkk keeeekkkqe egekmknede enkknedeek kkneeeekkk 1141 qeeknkkned eekkkqeeee kkkneeeekk kqeeghsn // LOCUS NP_012723 662 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase PTK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012723 VERSION NP_012723.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179764.2 REFERENCE 1 (residues 1 to 662) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 662) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 662) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 662) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 662) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08968. On Apr 26, 2011 this sequence version replaced NP_012723.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..662 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..662 /product="putative serine/threonine protein kinase PTK1" /EC_number="2.7.11.1" /calculated_mol_wt="73372" Region 202..503 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(202..205,208,210,224,226,260,282..285,329,333..334, 336,346..347) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270896" CDS 1..662 /gene="PTK1" /locus_tag="YKL198C" /gene_synonym="KKT8; POT1; STK1; YKL199C; YKT9" /coded_by="NM_001179764.2:1..1989" /experiment="EXISTENCE:genetic interaction:GO:0000296 spermine transport [PMID:7488221]" /note="Putative serine/threonine protein kinase; regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein; PTK1 has a paralog, PTK2, that arose from the whole genome duplication" /db_xref="GeneID:853635" /db_xref="SGD:S000001681" ORIGIN 1 mtvshnhstk isqqpissvs afkffgkkll ssshgnklkk kaslppdfhs tstndsesss 61 pklpnslkts rransfahtt nskrslssas tkilppagss tsisrgnrhs stsrnlsnsk 121 fsserlvynp ygvstpstsl ssvstsmkkd pdlgfylhdg dskirmlpip ivdpneylpd 181 emkeasiqls dnfvfddenk tigwggscev rkirskyrkk dvfalkklnm iynetpekfy 241 krcskefiia kqlshhvhit ntfllvkvpt tvyttrgwgf vmelglrdlf amiqksgwrs 301 valaekfcif kqvacgvkfc hdqgiahrdl kpenvllspd gvckltdfgi sdwyhtdphd 361 lsspvkkcag migsppyapp evmfydskkh ydtelqqpyd praldcyglg iilmtlvnnv 421 ipflescsfd tgfrdycday enfirlhdra frnrgnyrpg pgmeyhlarn fknghasrva 481 wrladpeaat rytiddlfed pwfqgietcv dandkyvckk piiktttyen prgfhiatdv 541 aattptsnpf lknrvpirsm vdiaahpspt atvlassppp pppathvpae alftlretpp 601 pqlatltlse eppatpapsa psapsarvrg hsphrvvhhh lnivnslvhs ssaassqvpa 661 st // LOCUS NP_012724 1043 aa linear PLN 30-JUN-2025 DEFINITION AAA family ATPase peroxin 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012724 VERSION NP_012724.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179763.1 REFERENCE 1 (residues 1 to 1043) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1043) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1043) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1043) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1043) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1043) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1043) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08969. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1043 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1043 /product="AAA family ATPase peroxin 1" /calculated_mol_wt="117145" Region 108..183 /region_name="PEX-1N" /note="Peroxisome biogenesis factor 1, N-terminal; pfam09262" /db_xref="CDD:462729" Region <401..1023 /region_name="CDC48" /note="AAA family ATPase, CDC48 subfamily; TIGR01243" /db_xref="CDD:273521" Region 705..862 /region_name="RecA-like_PEX1_r2" /note="second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); cd19526" /db_xref="CDD:410934" Site order(739..746,841) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:410934" CDS 1..1043 /gene="PEX1" /locus_tag="YKL197C" /gene_synonym="PAS1" /coded_by="NM_001179763.1:1..3132" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:16911527]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016558 protein import into peroxisome matrix [PMID:29321502]" /experiment="EXISTENCE:direct assay:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:0043335 protein unfolding [PMID:29321502]" /experiment="EXISTENCE:direct assay:GO:1904949 ATPase complex [PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:1990351 transporter complex [PMID:16007078]" /experiment="EXISTENCE:genetic interaction:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]" /experiment="EXISTENCE:mutant phenotype:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:15634331]" /note="AAA-peroxin; heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis; mutations in human PEX1 can lead to severe peroxisomal disorders and early death" /db_xref="GeneID:853636" /db_xref="SGD:S000001680" ORIGIN 1 mtttkrlkfe nlriqfsnai vgnflrlphs iinvlestny aiqefgiavh shnsdipivh 61 lgwdghdsgs senvvlinpv latvydlnqk splvdlyiqr ydhthlatev yvtpetsddw 121 eiidanamrf qngeilhqtr ivtpgetlic ylegivtkfk idrvepsmks aritdgslvv 181 vapkvnktrl vkaeyghsnk tilkngaiql lkkvilrstv ckmdfpkdnl fvvyisdgaq 241 lpsqkgyasi vkcslrqskk sdsdnksvgi pskkigvfik cdsqipenhi alsshlwdaf 301 fthpmngaki kleflqmnqa niisgrnatv nikyfgkdvp tksgdqyskl lggslltnnl 361 ilpteqiiie ikkgeseqql cnlneisnes vqwkvtqmgk eevkdiierh lpkhyhvket 421 gevsrtskde ddfitvnsik kemvnyltsp iiatpaiild gkqgigktrl lkelinevek 481 dhhifvkyad cetlhetsnl dktqklimew csfcywygps livldnveal fgkpqandgd 541 psnngqwdna skllnffinq vtkifnkdnk rirvlfsgkq ktqinpllfd khfvsetwsl 601 rapdkharak lleyffsknq imklnrdlqf sdlsletegf spldleifte kifydlqler 661 dcdnvvtrel fskslsaftp salrgvkltk etnikwgdig alanakdvll etlewptkye 721 pifvncplrl rsgillygyp gcgktllasa vaqqcglnfi svkgpeilnk figaseqnir 781 elferaqsvk pcilffdefd siapkrghds tgvtdrvvnq lltqmdgaeg ldgvyilaat 841 srpdlidsal lrpgrldksv icnipteser ldilqaivns kdkdtgqkkf aleknadlkl 901 iaektagfsg adlqglcyna ylksvhrwls aadqsevvpg ndnieyfsin ehgrreenrl 961 rlktllqqdv vhetktstsa aseltavvti ndlleacqet kpsistselv klrgiydrfq 1021 kdrngempng ensidigsrl slm // LOCUS NP_012725 200 aa linear PLN 30-JUN-2025 DEFINITION palmitoyltransferase YKT6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012725 VERSION NP_012725.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179762.1 REFERENCE 1 (residues 1 to 200) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 200) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 200) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 200) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08970. Method: conceptual translation. FEATURES Location/Qualifiers source 1..200 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..200 /product="palmitoyltransferase YKT6" /calculated_mol_wt="22576" Region 3..200 /region_name="SNC1" /note="Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]; COG5143" /db_xref="CDD:227472" CDS 1..200 /gene="YKT6" /locus_tag="YKL196C" /coded_by="NM_001179762.1:1..603" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:15723044]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:40049413]" /experiment="EXISTENCE:direct assay:GO:0000421 autophagosome membrane [PMID:33025734]" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:33025734|PMID:11959998]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:18541004]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:40049413]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:18541004]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11959998]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9211930]" /experiment="EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:14685280]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11959998]" /experiment="EXISTENCE:direct assay:GO:0033106 cis-Golgi network membrane [PMID:40049413]" /experiment="EXISTENCE:direct assay:GO:0061909 autophagosome-lysosome fusion [PMID:33025734]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9211930]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:10591633]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10385523]" /note="Vesicle membrane protein and R class v-SNARE; contains SNAP receptor and acyltransferase activities; subunit of multiple SNARE complexes involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and autophagosome-vacuolar fusion; C-terminal farnesylation and geranylgeranylation are essential for membrane localization and for function in cell wall integrity and autophagy; targeted to the vacuole via the AP-3 pathway; human homolog YKT6 complements a yeast ykt6 mutant" /db_xref="GeneID:853638" /db_xref="SGD:S000001679" ORIGIN 1 mriyyigvfr sggekalels evkdlsqfgf ferssvgqfm tffaetvasr tgagqrqsie 61 egnyighvya rsegicgvli tdkeypvrpa ytllnkilde ylvahpkeew advtetndal 121 kmkqldtyis kyqdpsqada imkvqqelde tkivlhktie nvlqrgekld nlvdkseslt 181 asskmfykqa kksnscciim // LOCUS NP_012726 403 aa linear PLN 30-JUN-2025 DEFINITION Mia40p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012726 VERSION NP_012726.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179761.1 REFERENCE 1 (residues 1 to 403) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 403) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 403) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 403) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08971. On Oct 2, 2003 this sequence version replaced NP_012726.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..403 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..403 /product="Mia40p" /calculated_mol_wt="44406" Region <68..282 /region_name="2A1904" /note="K+-dependent Na+/Ca+ exchanger; TIGR00927" /db_xref="CDD:273344" Region 307..343 /region_name="CHCH" /note="CHCH domain; pfam06747" /db_xref="CDD:429096" CDS 1..403 /gene="MIA40" /locus_tag="YKL195W" /gene_synonym="FMP15; TIM40" /coded_by="NM_001179761.1:1..1212" /experiment="EXISTENCE:direct assay:GO:0003756 protein disulfide isomerase activity [PMID:25451030]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:14690591|PMID:24769239|P MID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15620710|PMID:15364952]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:25451030|PMID:15359280]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:22990235|PMID:25451030]" /experiment="EXISTENCE:direct assay:GO:0016972 thiol oxidase activity [PMID:25451030]" /experiment="EXISTENCE:direct assay:GO:0051537 2 iron, 2 sulfur cluster binding [PMID:23834247]" /experiment="EXISTENCE:mutant phenotype:GO:0016491 oxidoreductase activity [PMID:22990235]" /experiment="EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:17336303|PMID:27343349|PMID:15359280|PMID:15364952]" /experiment="EXISTENCE:physical interaction:GO:0045041 protein import into mitochondrial intermembrane space [PMID:15989955]" /note="Import and assembly protein in mitochondrial intermembrane space; component of MIA pathway which mediates import and oxidative folding of substrates including small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p via a chaperone-like activity; forms a dimer that binds iron-sulfur cluster in vitro" /db_xref="GeneID:853639" /db_xref="SGD:S000001678" ORIGIN 1 mlrnlvvrna crnrpsiqva rglcrhqtrr lmasspqfgr nsnqektagf imgilsmaga 61 lyfiapnrkp lfasrkvesd ktaeeelssg geqspenedd nnsksdengd dndskndete 121 agpqlggdki gaskvaedge lvvlaeednk ssedkdtdes kvstkddeqs nednatannq 181 kdenissens eentsdktld nnagssekkd pehsddeksq qgqsddkttt ednngeeess 241 kktvsdsens akqsessdee keelrkqeek qmgpteeevq hegaynpdtg einwdcpclg 301 gmahgpcgee fksafscfvy seaepkgidc vekfqhmqdc frkypehyae qlketsddee 361 pqdkvkvnti esapnvssak enaakkaeqs dvkkeplnee skp // LOCUS NP_012727 462 aa linear PLN 30-JUN-2025 DEFINITION threonine--tRNA ligase MST1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012727 VERSION NP_012727.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179760.1 REFERENCE 1 (residues 1 to 462) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 462) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 462) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 462) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08972. Method: conceptual translation. FEATURES Location/Qualifiers source 1..462 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..462 /product="threonine--tRNA ligase MST1" /EC_number="6.1.1.3" /calculated_mol_wt="53961" Region <47..457 /region_name="ThrS" /note="Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; COG0441" /db_xref="CDD:440210" CDS 1..462 /gene="MST1" /locus_tag="YKL194C" /coded_by="NM_001179760.1:1..1389" /experiment="EXISTENCE:direct assay:GO:0004829 threonine-tRNA ligase activity [PMID:21321019]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:2999113|PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0070159 mitochondrial threonyl-tRNA aminoacylation [PMID:21321019]" /experiment="EXISTENCE:mutant phenotype:GO:0004829 threonine-tRNA ligase activity [PMID:2999113]" /note="Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(UAG)Q2 in vitro; lacks a typical editing domain, but has pre-transfer editing activity stimulated by the unusual tRNA-Thr" /db_xref="GeneID:853640" /db_xref="SGD:S000001677" ORIGIN 1 mkiqlvrwhc srnalwnraf ystrkatkna ssatpatmts mvsqrqdlfm tdplspgsmf 61 flpngakifn kliefmklqq kfkfgfnevv tpliykktlw eksghwenya ddmfkvettd 121 eekeeyglkp mncpghclif gkkdrsynel plrfsdfspl hrneasgals gltrlrkfhq 181 ddghifctps qvkseifnsl klidivynki fpfvkggsga esnyfinfst rpdhfigdlk 241 vwnhaeqvlk eileesgkpw klnpgdgafy gpkldimvtd hlrkthqvat iqldfqlper 301 fdlkfkdqdn sykrpimihr atfgsierfm allidsnegr wpfwlnpyqa viipvntknv 361 qqldmctalq kklrnelead dmepvplndw hfnvdldirn epvgyriksa ilknysylii 421 vgdeevqlqk ynirerdnrk sfekltmsqi wekfielekn yk // LOCUS NP_012728 338 aa linear PLN 30-JUN-2025 DEFINITION type 1 protein phosphatase-activating protein SDS22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012728 VERSION NP_012728.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179759.1 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 338) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08973. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..338 /product="type 1 protein phosphatase-activating protein SDS22" /calculated_mol_wt="38756" Region 44..67 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region <49..169 /region_name="PPP1R42" /note="protein phosphatase 1 regulatory subunit 42; cl42388" /db_xref="CDD:455733" Region 68..91 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 92..114 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 112..332 /region_name="PPP1R42" /note="protein phosphatase 1 regulatory subunit 42; cl42388" /db_xref="CDD:455733" Region 115..136 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 137..158 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 159..182 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 183..204 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 205..248 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 249..270 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 271..294 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" CDS 1..338 /gene="SDS22" /locus_tag="YKL193C" /gene_synonym="EGP1" /coded_by="NM_001179759.1:1..1017" /experiment="EXISTENCE:direct assay:GO:0000164 protein phosphatase type 1 complex [PMID:10775415]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:11801737|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:17142459]" /experiment="EXISTENCE:genetic interaction:GO:0072542 protein phosphatase activator activity [PMID:18172024|PMID:11801737]" /experiment="EXISTENCE:mutant phenotype:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:17142459]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11801737]" /experiment="EXISTENCE:mutant phenotype:GO:0051457 maintenance of protein location in nucleus [PMID:11801737]" /note="Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p; whether it functions as a positive or negative regulator of Glc7p is controversial; involved in the regulation of Glc7p nuclear localization and function" /db_xref="GeneID:853641" /db_xref="SGD:S000001676" ORIGIN 1 mdknsvnkds eekderhkie vvddtnpdfi tadseltqdl pddvevidlv hlkiksledl 61 nlyrfknlkq lclrqnlies isevevlphd kivdldfydn kikhissnvn kltkltsldl 121 sfnkikhikn lenltdlenl yfvqnsiski enlstlkslk nlelggnkvh siepdsfegl 181 snleeiwlgk nsiprlinlh plknlkilsi qsnklkkien leeltnleel ylshnfitki 241 egleknlklt tldvtsnkit slenlnhlsn ltdiwasfnk idqsfeslge nlsalsrlet 301 iylegnpiql enktsyrrkl tmnlppslqk idatyirg // LOCUS NP_012729 125 aa linear PLN 30-JUN-2025 DEFINITION acyl carrier protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012729 VERSION NP_012729.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179758.1 REFERENCE 1 (residues 1 to 125) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 125) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 125) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 125) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08974. Method: conceptual translation. FEATURES Location/Qualifiers source 1..125 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..125 /product="acyl carrier protein" /calculated_mol_wt="13812" Region 46..122 /region_name="acyl_carrier" /note="acyl carrier protein; TIGR00517" /db_xref="CDD:213536" CDS 1..125 /gene="ACP1" /locus_tag="YKL192C" /coded_by="NM_001179758.1:1..378" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0009107 lipoate biosynthetic process [PMID:9187370]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:27540631]" /experiment="EXISTENCE:physical interaction:GO:0099128 mitochondrial [2Fe-2S] assembly complex [PMID:27540631]" /note="Mitochondrial matrix acyl carrier protein; involved in biosynthesis of octanoate, which is a precursor to lipoic acid; coordinates mitochondrial fatty acid and iron sulfur cluster metabolism; activated by phosphopantetheinylation catalyzed by Ppt2p" /db_xref="GeneID:853642" /db_xref="SGD:S000001675" ORIGIN 1 mfrsvcriss rvapsayrti mgrsvmsnti laqrfysanl skdqvsqrvi dvikafdkns 61 pniankqiss dtqfhkdlgl dsldtvellv aieeefdiei pdkvadelrs vgetvdyias 121 npdan // LOCUS NP_012730 534 aa linear PLN 30-JUN-2025 DEFINITION 2-(3-amino-3-carboxypropyl)histidine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012730 VERSION NP_012730.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179757.1 REFERENCE 1 (residues 1 to 534) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 534) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 534) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 534) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08975. Method: conceptual translation. FEATURES Location/Qualifiers source 1..534 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..534 /product="2-(3-amino-3-carboxypropyl)histidine synthase" /calculated_mol_wt="59645" Region 11..524 /region_name="DPH2" /note="diphthamide biosynthesis protein 2; TIGR00272" /db_xref="CDD:272990" CDS 1..534 /gene="DPH2" /locus_tag="YKL191W" /coded_by="NM_001179757.1:1..1605" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0017183 protein histidyl modification to diphthamide [PMID:15485916|PMID:8406038]" /note="Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph1p that catalyzes the first step of diphthamide biosynthesis" /db_xref="GeneID:853643" /db_xref="SGD:S000001674" ORIGIN 1 mevapalstt qsdvafqkve theidrssyl gpcynsdelm qlisayynve plvgyleqhp 61 eyqnvtlqfp ddlikdssli vrllqskfph gkikfwvlad taysaccvde vaaehvhaev 121 vvhfgdacln aiqnlpvvys fgtpfldlal vvenfqrafp dlsskiclma napfskhlsq 181 lynilkgdlh ytniiysqvn tsaveekfvt ildtfhvped vdqvgvfekn svlfgqhdka 241 dnispedyhl fhlttpqdpr llylstvfqs vhifdpalpg mvtgpfpslm rrykymhvar 301 tagcigilvn tlslrntret inelvklikt rekkhylfvv gkpnvaklan fedidiwcil 361 gcsqsgiivd qfnefykpii tpyelnlals eevtwtgkwv vdfrdaidei eqnlggqdti 421 sasttsdepe fdvvrgryts tsrplralth leleaadddd skqlttrhta sgavikgtvs 481 tsasalqnrs wkglgsdfds tevdntgadi eegisgvarg ygfdredamk kenk // LOCUS NP_012731 175 aa linear PLN 30-JUN-2025 DEFINITION calcineurin regulatory subunit B [Saccharomyces cerevisiae S288C]. ACCESSION NP_012731 VERSION NP_012731.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179756.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 175) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08976. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..175 /product="calcineurin regulatory subunit B" /calculated_mol_wt="19508" Region 23..161 /region_name="FRQ1" /note="Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; COG5126" /db_xref="CDD:444056" CDS 1..175 /gene="CNB1" /locus_tag="YKL190W" /gene_synonym="CRV1; YCN2" /coded_by="NM_001179756.1:1..528" /experiment="EXISTENCE:direct assay:GO:0004723 calcium-dependent protein serine/threonine phosphatase activity [PMID:1321337]" /experiment="EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:1321337]" /experiment="EXISTENCE:direct assay:GO:0005955 calcineurin complex [PMID:1321337]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:1321337]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:8798496]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:1321337]" /note="Calcineurin B; regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (stress-response transcription factor); other calcineurin subunit encoded by CNA1 and/or CMP1; regulates function of Aly1p alpha-arrestin; myristoylation by Nmt1p reduces calcineurin activity in response to submaximal Ca signals, is needed to prevent constitutive phosphatase activity; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853644" /db_xref="SGD:S000001673" ORIGIN 1 mgaapskivd glledtnfdr deierlrkrf mkldrdssgs idknefmsip gvssnplagr 61 imevfdadns gdvdfqefit glsifsgrgs kdeklrfafk iydidkdgfi sngelfivlk 121 imvgsnldde qlqqivdrti vendsdgdgr lsfeefknai ettevakslt lqydv // LOCUS NP_012732 399 aa linear PLN 30-JUN-2025 DEFINITION Hym1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012732 VERSION NP_012732.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179755.1 REFERENCE 1 (residues 1 to 399) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 399) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 399) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 399) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08977. Method: conceptual translation. FEATURES Location/Qualifiers source 1..399 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..399 /product="Hym1p" /calculated_mol_wt="45722" Region 14..354 /region_name="Mo25" /note="Mo25-like; pfam08569" /db_xref="CDD:462522" CDS 1..399 /gene="HYM1" /locus_tag="YKL189W" /coded_by="NM_001179755.1:1..1200" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12972564]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12972564]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12972564]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:11259593]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:12972564]" /note="Component of the RAM signaling network; is involved in regulation of Ace2p activity and cellular morphogenesis; interacts with Sog2p; allosterically activates Kic1p; localizes to sites of polarized growth during budding and during the mating response" /db_xref="GeneID:853646" /db_xref="SGD:S000001672" ORIGIN 1 mfkkyknqdl dmafwwkknp ktpsdyarli ieqlnkfssp sltqdnkrkv qeectkylig 61 tkhfivgdtd phptpeaide lytamhradv fyelllhfvd lefearrecm lifsiclgys 121 kdnkfvtvdy lvsqpktisl mlrtaevalq qkgcqdiflt vgnmiiecik yeqlcriilk 181 dpqlwkffef aklgnfeist eslqilsaaf tahpklvske ffsneiniir fikcinklma 241 hgsyvtkrqs tkllaslivi rsnnalmniy inspenlkli mtlmtdkskn lqleafnvfk 301 vmvanprksk pvfdilvknr dklltyfktf gldsqdstfl derefivqei dslpriisst 361 tevsnnnass snvasitsps svmnnqssil thstspdsr // LOCUS NP_012733 853 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette long-chain fatty acid transporter PXA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012733 VERSION NP_012733.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179754.1 REFERENCE 1 (residues 1 to 853) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 853) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 853) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 853) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08978. Method: conceptual translation. FEATURES Location/Qualifiers source 1..853 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..853 /product="ATP-binding cassette long-chain fatty acid transporter PXA2" /calculated_mol_wt="96996" Region 24..728 /region_name="3a01203" /note="Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein; TIGR00954" /db_xref="CDD:273360" CDS 1..853 /gene="PXA2" /locus_tag="YKL188C" /gene_synonym="PAT1" /coded_by="NM_001179754.1:1..2562" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27663510]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:35127709|PMID:9395310]" /experiment="EXISTENCE:direct assay:GO:0015867 ATP transport [PMID:35127709]" /experiment="EXISTENCE:direct assay:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:35127709|PMID:9395310]" /experiment="EXISTENCE:direct assay:GO:1902001 fatty acid transmembrane transport [PMID:9395310]" /note="Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transportesr ABCD1 and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" /db_xref="GeneID:853647" /db_xref="SGD:S000001671" ORIGIN 1 mistasafyq khrvnllrss yiilllatly nsnssssnnk tdkkdsestv lenkkieegk 61 etavdreede sskeeltivs khstdsedga iiidkesktn hkggerkgkv dflfklllhd 121 kkclilfitq aillnirtll slrvatldgq lvstlvraqy anftkillgk wmilgipasf 181 inslisyttk lcavtinrkv sdfllskyls nhhtfysvas aesvseiqdn ltkdiytfsm 241 nsslllnqll kpmldlilcs fklltsntsv mgegtlalgl ivyasnsllk liqpnftrlt 301 masasleswf rslhsnlhss neeiallrgq krelenvdys fyrlvlflnr eikaraiydv 361 atafvikytw gaaglvlcsi piffknkpse dtlqlkepgn dmtadfitnr rllvtasssi 421 grfvelkrni qqlrgirlrl nkfndlldan kgddekeprd erciveydds rikfenipli 481 tpanqvlvpe lsfdlkhgnh lliigpngcg ksslfrilgg lwpiratpnk nhqsklimpr 541 rtvdrdcaif ylpqrpymgn rstfreqiiy pdsieqfker yhndydlgda dlikilqlld 601 ledlvtenms lllaqrtskn dsqqlstedn qspcaikvrd afsivrnwse eltigvqqrl 661 amarmyyhkp kfavldects avapemeqrm yenaqnfgis lisvchrtsl whfhnyllkf 721 dgkggyqfgp fnpkerlcne ekllelnail dqqvplwerk lkdltiakes niirksetnl 781 nlfekiedpk tsksnalfna nkgqritspt gqetskrlpl fsqpsssass nllrnnksln 841 kkvktkkeeg ker // LOCUS NP_012734 750 aa linear PLN 30-JUN-2025 DEFINITION Fat3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012734 VERSION NP_012734.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179753.1 REFERENCE 1 (residues 1 to 750) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 750) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 750) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 750) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08979. Method: conceptual translation. FEATURES Location/Qualifiers source 1..750 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..750 /product="Fat3p" /calculated_mol_wt="80902" Region <465..640 /region_name="SUR7" /note="SUR7/PalI family; cl24030" /db_xref="CDD:420163" CDS 1..750 /gene="FAT3" /locus_tag="YKL187C" /coded_by="NM_001179753.1:1..2253" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015909 long-chain fatty acid transport [PMID:23349476]" /note="Protein required for fatty acid uptake; protein abundance increases in cortical patches in response to oleate exposure; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; FAT3 has a paralog, YLR413W, that arose from the whole genome duplication" /db_xref="GeneID:853648" /db_xref="SGD:S000001670" ORIGIN 1 mriekhrtpl skgiiwtils vcllfmfttl ilvivatags tanykpltni yigeadikhi 61 nvskvipqig piltilgsal tapnsslddi fgamkniadt paltplltll snadnttvti 121 esltelapla isgnpasstr qlteingllk ysdnatetld glsrlvsasl ssassnsssd 181 sttlvldllk dsdnpqnstd alltlnnltm sekaqllpvf rlfafstnqt atmtalatlm 241 nttissslaq tlltqlqnti snggslnntf stlqplvpqa sapafdavel llnqttstnq 301 tlstlsdlle qnltqsssak kafaaltqlm ensdnstmvv tsvqslaavt nttqstqqli 361 glddvissss ntnetlsils elqsglsgns ssvqyipylf sllgastdpk ttfsslvtlt 421 swaqenpqtf lpildilada ksvqpisaee lnamtpnile ylkipiyyrl siftlchanl 481 enkildcnsp havqnldfrs iiydalvtsd fqpylnalni sandlylegk llhrehqyvp 541 avrsvlalnl laiifsfftm ifiillyfnr ymfkqplwli alalhvcvgv atvlaaiiis 601 vmiaiiksgt addkygvvfk agpaytgliw tafalsfiat gliiytwwrn rrsgrymsgs 661 vtnrkgeiyt ygdgsaisad rfgdhnlgdd ddadfekqvn rneitaidns ssanntdvtg 721 stsnrtelsh pdvtpkdsng pvnnnahlva // LOCUS NP_012735 184 aa linear PLN 30-JUN-2025 DEFINITION Mtr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012735 VERSION NP_012735.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179752.1 REFERENCE 1 (residues 1 to 184) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 184) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 184) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 184) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08980. Method: conceptual translation. FEATURES Location/Qualifiers source 1..184 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..184 /product="Mtr2p" /calculated_mol_wt="20652" Region 13..184 /region_name="Mtr2" /note="Nuclear pore RNA shuttling protein Mtr2; pfam10429" /db_xref="CDD:402175" CDS 1..184 /gene="MTR2" /locus_tag="YKL186C" /coded_by="NM_001179752.1:1..555" /experiment="EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:17434126]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:17434126|PMID:31439809]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:22956913]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:29212662]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:29212662]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:9774696|PMID:7865887]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10952996]" /experiment="EXISTENCE:physical interaction:GO:0042272 nuclear RNA export factor complex [PMID:9774696]" /note="mRNA transport regulator; essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA" /db_xref="GeneID:853649" /db_xref="SGD:S000001669" ORIGIN 1 mntnsntmvm ndanqaqita tftkkilahl ddpdsnklaq fvqlfnpnnc riifnatpfa 61 qatvflqmwq nqvvqtqhal tgvdyhaipg sgtlicnvnc kvrfdesgrd kmgqdatvpi 121 qpnntgnrnr pndmnkprpl wgpyfgislq liiddrifrn dfngvisgfn ynmvykpeds 181 llki // LOCUS NP_012736 588 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcription repressor ASH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012736 VERSION NP_012736.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179751.1 REFERENCE 1 (residues 1 to 588) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 588) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 588) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 588) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08981. Method: conceptual translation. FEATURES Location/Qualifiers source 1..588 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..588 /product="DNA-binding transcription repressor ASH1" /calculated_mol_wt="65554" Region 494..548 /region_name="ZnF_GATA" /note="zinc finger binding to DNA consensus sequence [AT]GATA[AG]; smart00401" /db_xref="CDD:214648" CDS 1..588 /gene="ASH1" /locus_tag="YKL185W" /coded_by="NM_001179751.1:1..1767" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:11171979]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:19841732]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9566907|PMID:8625408|PMID:8625409]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:8625408|PMID:8625409]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:19040720|PMID:16314178|PMID:16286007]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8625409|PMID:8625408]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:11171979]" /experiment="EXISTENCE:mutant phenotype:GO:0031495 negative regulation of mating type switching [PMID:8625408|PMID:8625409]" /experiment="EXISTENCE:mutant phenotype:GO:1900461 positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter [PMID:11046133]" /note="Component of the Rpd3L histone deacetylase complex; zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate" /db_xref="GeneID:853650" /db_xref="SGD:S000001668" ORIGIN 1 msslyiktpl halsagpdsh anssyydnll lpsfsnlssn isrnnittdn ninsasprky 61 sfhslnvspi lspislanei lgkksntapa sphhmdynpi ssltpgnspe fnkaslsqis 121 ftnplnygsg lgfssnsqpr lplldrlssv slskrperpq qslpslrhlq llpspllqen 181 aarfpdtskr tsnwktdlth wckdtnyqdy vkireevahf kplsipnltn nqnndsfnyg 241 kelestrssk fhspskesfd rtklipsile akdqfkdlsn nawsitppvt ppmspptnrt 301 merttlrgve asffegkssn ndsifnpiis eklvqevkhq rqlrgnsfpm pnashkktns 361 fkalqikkll anrdilsnns ksnvrkpskn kiskqasnvf gntarqlvmk ldnasyssvs 421 assspspstp tksgkmrsrs sspvrpkayt psprspnyhr faldsppqsp rrssnssitk 481 kgsrrssgss ptrhttrvcv schssdspcw rpswsprkqd qlcnscglry kkthtrclnd 541 lcrkiptkge inimksngid kefvpernce iegyrclfcn yitetven // LOCUS NP_012737 466 aa linear PLN 30-JUN-2025 DEFINITION ornithine decarboxylase SPE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012737 VERSION NP_012737.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179750.1 REFERENCE 1 (residues 1 to 466) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 466) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 466) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 466) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08982. Method: conceptual translation. FEATURES Location/Qualifiers source 1..466 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..466 /product="ornithine decarboxylase SPE1" /EC_number="4.1.1.17" /calculated_mol_wt="52154" Region 84..460 /region_name="PLPDE_III_ODC" /note="Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; cd00622" /db_xref="CDD:143482" Site order(85,116,137..138,140..141,163,168,181,184,188, 215..217,335,337..338,346,348,350,353..354,362,364,408,410, 412,415,445,447,449..451,453) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:143482" Site order(114,116,135,201,244,247,285..286,318..321,363,411, 441) /site_type="active" /db_xref="CDD:143482" Site order(114,116,135,201,244,247,285..286,318..321,411,441) /site_type="other" /note="pyridoxal 5'-phosphate (PLP) binding site [chemical binding]" /db_xref="CDD:143482" Site order(116,411) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:143482" Site order(362..363,411..412,441,449) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:143482" CDS 1..466 /gene="SPE1" /locus_tag="YKL184W" /gene_synonym="ORD1; SPE10" /coded_by="NM_001179750.1:1..1401" /experiment="EXISTENCE:direct assay:GO:0004586 ornithine decarboxylase activity [PMID:2681188]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0009446 putrescine biosynthetic process [PMID:7929015]" /experiment="EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]" /note="Ornithine decarboxylase; catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation" /db_xref="GeneID:853651" /db_xref="SGD:S000001667" ORIGIN 1 msstqvgnal ssstttlvdl snstvtqkkq yykdgetlhn lllelknnqd lellpheqah 61 pkifqalkar igrinnetcd pgeensffic dlgevkrlfn nwvkelprik pfyavkcnpd 121 tkvlsllael gvnfdcaskv eidrvlsmni spdrivyanp ckvasfirya asknvmkstf 181 dnveelhkik kfhpesqlll riatddstaq crlstkygce menvdvllka ikelglnlag 241 vsfhvgsgas dftslykavr dartvfdkaa neyglpplki ldvgggfqfe sfkestavlr 301 laleeffpvg cgvdiiaepg ryfvataftl ashviakrkl seneamiytn dgvygnmnci 361 lfdhqephpr tlyhnlefhy ddfesttavl dsinktrsey pykvsiwgpt cdgldciake 421 yymkhdvivg dwfyfpalga ytssaatqfn gfeqtadivy idseld // LOCUS NP_878109 70 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKL183C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878109 VERSION NP_878109.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184557.1 REFERENCE 1 (residues 1 to 70) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 70) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 70) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 70) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08983. Method: conceptual translation. FEATURES Location/Qualifiers source 1..70 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..70 /product="uncharacterized protein" /calculated_mol_wt="8227" CDS 1..70 /locus_tag="YKL183C-A" /coded_by="NM_001184557.1:1..213" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1500485" /db_xref="SGD:S000028558" ORIGIN 1 myskillyrs nvlfmnffsv fvctigtlfl vfadvyvlas affqskkeke tkfkhlhyqk 61 rscfflanih // LOCUS NP_012738 306 aa linear PLN 30-JUN-2025 DEFINITION Lot5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012738 VERSION NP_012738.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179749.1 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 306) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08984. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..306 /product="Lot5p" /calculated_mol_wt="34195" Region 83..>216 /region_name="Voldacs" /note="Regulator of volume decrease after cellular swelling; pfam03517" /db_xref="CDD:427344" CDS 1..306 /gene="LOT5" /locus_tag="YKL183W" /coded_by="NM_001179749.1:1..921" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; gene expression increases in cultures shifted to a lower temperature; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853652" /db_xref="SGD:S000001666" ORIGIN 1 mmkkkpkcqi artkpsvenv ipynqfkktq prfngnfsal nneeyiilfg ggrdlilgsl 61 tpcssshlsn qanpqdtsey gtdlfilnsc iiiwfnglgy gleipyssvl yhasrrlpdg 121 reglqleill tlerdevldm lyqslapqac efdgeeahaf tvrsveltir pkysiydrhy 181 nneietlftf enfgvnrgdd lvnncneala vcmdlhgedv qdqdqeqyqd psmafegaqd 241 lnatysglgd tlhgppvyqn dgladdldgd lvmdnvvsrg gpeasmsmef yanqnlagrk 301 nsrdne // LOCUS NP_012739 2051 aa linear PLN 30-JUN-2025 DEFINITION tetrafunctional fatty acid synthase subunit FAS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012739 VERSION NP_012739.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179748.1 REFERENCE 1 (residues 1 to 2051) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2051) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 2051) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 2051) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2051) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2051) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2051) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08985. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2051 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..2051 /product="tetrafunctional fatty acid synthase subunit FAS1" /EC_number="1.3.1.9" /EC_number="2.3.1.38" /EC_number="2.3.1.39" /EC_number="2.3.1.86" /EC_number="3.1.2.14" /EC_number="4.2.1.59" /calculated_mol_wt="228561" Region 5..131 /region_name="FAS_N" /note="N-terminal domain in fatty acid synthase subunit beta; pfam17828" /db_xref="CDD:407694" Region 158..413 /region_name="SAT" /note="Starter unit:ACP transacylase in aflatoxin biosynthesis; pfam16073" /db_xref="CDD:465005" Region <335..493 /region_name="Acyl_transf_1" /note="Acyl transferase domain; cl08282" /db_xref="CDD:471802" Region 590..>821 /region_name="NMO" /note="Nitronate monooxygenase; pfam03060" /db_xref="CDD:367316" Region 727..1074 /region_name="DUF1729" /note="Domain of unknown function (DUF1729); pfam08354" /db_xref="CDD:369827" Region 1134..1271 /region_name="FAS_meander" /note="Fatty acid synthase meander beta sheet domain; pfam17951" /db_xref="CDD:407799" Region 1284..1406 /region_name="hot_dog" /note="The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; cl00509" /db_xref="CDD:469797" Region 1536..1660 /region_name="FAS_MaoC" /note="the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); cd03447" /db_xref="CDD:239531" Site order(1554,1559,1561,1564,1579,1582..1583) /site_type="active" /note="putative active site [active]" /db_xref="CDD:239531" Site order(1559,1561,1564,1582) /site_type="active" /note="putative catalytic site [active]" /db_xref="CDD:239531" Region 1663..2037 /region_name="Acyl_transf_1" /note="Acyl transferase domain; pfam00698" /db_xref="CDD:395567" CDS 1..2051 /gene="FAS1" /locus_tag="YKL182W" /coded_by="NM_001179748.1:1..6156" /experiment="EXISTENCE:direct assay:GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity [PMID:374077]" /experiment="EXISTENCE:direct assay:GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity [PMID:365179|PMID:374077]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:17803462]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:6025308]" /experiment="EXISTENCE:direct assay:GO:0005835 fatty acid synthase complex [PMID:65153]" /experiment="EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:365179]" /experiment="EXISTENCE:direct assay:GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [PMID:374077]" /experiment="EXISTENCE:direct assay:GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity [PMID:374077]" /experiment="EXISTENCE:mutant phenotype:GO:0004312 fatty acid synthase activity [PMID:65153|PMID:1100391]" /experiment="EXISTENCE:mutant phenotype:GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity [PMID:1100391]" /experiment="EXISTENCE:mutant phenotype:GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity [PMID:1100391]" /experiment="EXISTENCE:mutant phenotype:GO:0016409 palmitoyltransferase activity [PMID:1100391]" /experiment="EXISTENCE:mutant phenotype:GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [PMID:1100391]" /experiment="EXISTENCE:mutant phenotype:GO:0042759 long-chain fatty acid biosynthetic process [PMID:4127627|PMID:1735446]" /experiment="EXISTENCE:mutant phenotype:GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity [PMID:1100391]" /note="Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities; specific target of the broad-spectrum antifungal NPD6433" /db_xref="GeneID:853653" /db_xref="SGD:S000001665" ORIGIN 1 mdaystrplt lshgslehvl lvptasffia sqlqeqfnki lpeptegfaa ddepttpael 61 vgkflgyvss lvepskvgqf dqvlnlclte fencylegnd ihalaakllq endttlvktk 121 eliknyitar imakrpfdkk snsalfravg egnaqlvaif ggqgntddyf eelrdlyqty 181 hvlvgdlikf saetlselir ttldaekvft qglnilewle npsntpdkdy llsipiscpl 241 igviqlahyv vtakllgftp gelrsylkga tghsqglvta vaiaetdswe sffvsvrkai 301 tvlffigvrc yeaypntslp psiledslen negvpspmls isnltqeqvq dyvnktnshl 361 pagkqveisl vngaknlvvs gppqslygln ltlrkakaps gldqsripfs erklkfsnrf 421 lpvaspfhsh llvpasdlin kdlvknnvsf nakdiqipvy dtfdgsdlrv lsgsiseriv 481 dciirlpvkw etttqfkath ildfgpggas glgvlthrnk dgtgvrviva gtldinpddd 541 ygfkqeifdv tsnglkknpn wleeyhpkli knksgkifve tkfskligrp pllvpgmtpc 601 tvspdfvaat tnagytiela gggyfsaagm taaidsvvsq iekgstfgin liyvnpfmlq 661 wgiplikelr skgypiqflt igagvpslev aseyietlgl kylglkpgsi daisqvinia 721 kahpnfpial qwtggrgggh hsfedahtpm lqmyskirrh pnimlifgsg fgsaddtypy 781 ltgewstkfd yppmpfdgfl fgsrvmiake vktspdakkc iaactgvpdd kweqtykkpt 841 ggivtvrsem gepihkiatr gvmlwkefde tifnlpknkl vptleakrdy iisrlnadfq 901 kpwfatvngq ardlatmtye evakrlvelm firstnswfd vtwrtftgdf lrrveerftk 961 sktlsliqsy slldkpdeai ekvfnaypaa reqflnaqdi dhflsmcqnp mqkpvpfvpv 1021 ldrrfeiffk kdslwqsehl eavvdqdvqr tcilhgpvaa qftkvidepi ksimdgihdg 1081 hikkllhqyy gddeskipav eyfggespvd vqsqvdsssv sedsavfkat sstdeeswfk 1141 alagseinwr hasflcsfit qdkmfvsnpi rkvfkpsqgm vveisngnts sktvvtlsep 1201 vqgelkptvi lkllkeniiq memienrtmd gkpvslplly nfnpdngfap isevmedrnq 1261 rikemywklw idepfnldfd prdvikgkdf eitakevydf thavgnnced fvsrpdrtml 1321 apmdfaivvg wraiikaifp ntvdgdllkl vhlsngykmi pgakplqvgd vvsttavies 1381 vvnqptgkiv dvvgtlsrng kpvmevtssf fyrgnytdfe ntfqktvepv yqmhiktskd 1441 iavlrskewf qlddedfdll nktltfetet evtfknanif ssvkcfgpik velptketve 1501 igivdyeaga shgnpvvdfl krngstleqk vnlenpipia vldsytpstn epyarvsgdl 1561 npihvsrhfa syanlpgtit hgmfssasvr alienwaads vssrvrgytc qfvdmvlpnt 1621 alktsiqhvg mingrklikf etrneddvvv ltgeaeieqp vttfvftgqg sqeqgmgmdl 1681 yktskaaqdv wnradnhfkd tygfsildiv innpvnltih fggekgkrir enysamifet 1741 ivdgklktek ifkeinehst sytfrsekgl lsatqftqpa ltlmekaafe dlkskglipa 1801 datfaghslg eyaalaslad vmsieslvev vfyrgmtmqv avprdelgrs nygmiainpg 1861 rvaasfsqea lqyvvervgk rtgwlveivn ynvenqqyva agdlraldtv tnvlnfiklq 1921 kidiielqks lsleeveghl feiideaskk savkprplkl ergfaciplv gisvpfhsty 1981 lmngvkpfks flkkniiken vkvarlagky ipnltakpfq vtkeyfqdvy dltgsepike 2041 iidnwekyeq s // LOCUS NP_012740 427 aa linear PLN 30-JUN-2025 DEFINITION ribose phosphate diphosphokinase subunit PRS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012740 VERSION NP_012740.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179747.1 REFERENCE 1 (residues 1 to 427) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 427) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 427) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 427) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08986. Method: conceptual translation. FEATURES Location/Qualifiers source 1..427 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..427 /product="ribose phosphate diphosphokinase subunit PRS1" /EC_number="2.7.6.1" /calculated_mol_wt="46917" Region 1..422 /region_name="PrsA" /note="Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; COG0462" /db_xref="CDD:440230" CDS 1..427 /gene="PRS1" /locus_tag="YKL181W" /gene_synonym="PRP1" /coded_by="NM_001179747.1:1..1284" /experiment="EXISTENCE:direct assay:GO:0002189 ribose phosphate diphosphokinase complex [PMID:15280369]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11101685]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0004749 ribose phosphate diphosphokinase activity [PMID:15280369]" /experiment="EXISTENCE:genetic interaction:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:15280369]" /experiment="EXISTENCE:mutant phenotype:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:10212224]" /note="5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; plays a key role in cell wall integrity (CWI) pathway; one of five related enzymes, which are active as heteromultimeric complexes; missense mutations in human homolog PRPS1 are associated with neuropathic Arts syndrome and Charcot-Marie Tooth (CMTX5) disease" /db_xref="GeneID:853654" /db_xref="SGD:S000001664" ORIGIN 1 mrkckifvgn shpelgnmvc qrlgiepapc tlkkfanget svqigvsvrd edvyviqsgs 61 psinddimel lilvsacrgg sarkitavip qfpyskqckm krhrgaitar mlanllvmag 121 adhvvsmdlh asqmqgfftk pvdnlyggps lakwirenve dyedavvvsk npggtkrvta 181 ladslkinfa mihtdrrrsk dlysqnkdlq qlklrkqsml rknrpiirqg dhpneeenii 241 lsngiqtari rnghvigdde adddedaile sdselhsidg ldshglggty davdsedeee 301 ipvlyreqli tlvgnvrgrs aiilddmidr pgsfisaaeh lvqncgakkv yvvathgift 361 gdcleeleks daidtivvtn typisgeria gskklvtidv spifaecirr dhygesisvl 421 fdslaal // LOCUS NP_012741 184 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL22 RPL17A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012741 VERSION NP_012741.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179746.1 REFERENCE 1 (residues 1 to 184) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 184) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 184) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 184) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08987. Method: conceptual translation. FEATURES Location/Qualifiers source 1..184 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..184 /product="60S ribosomal protein uL22 RPL17A" /calculated_mol_wt="20418" Region 1..178 /region_name="PTZ00178" /note="60S ribosomal protein L17; Provisional" /db_xref="CDD:240306" Site order(15..16,38..40,42..43,45..46,99..104,112..117, 149..150) /site_type="active" /note="putative translocon binding site [active]" /db_xref="CDD:238205" Site order(18,20,23,25..27,30,34,37,97,101,104,116,118..120,122, 125,137..142) /site_type="other" /note="protein-rRNA interface [nucleotide binding]" /db_xref="CDD:238205" CDS 1..184 /gene="RPL17A" /locus_tag="YKL180W" /gene_synonym="RPL17" /coded_by="NM_001179746.1:1..555" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23268442]" /experiment="EXISTENCE:genetic interaction:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23268442]" /note="Ribosomal 60S subunit protein L17A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; copurifies with the Dam1 complex (aka DASH complex); homologous to mammalian ribosomal protein L17 and bacterial L22; RPL17A has a paralog, RPL17B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853674" /db_xref="SGD:S000001663" ORIGIN 1 marygatstn paksasargs ylrvsfkntr etaqaingwe ltkaqkyleq vldhqraipf 61 rrfnssigrt aqgkefgvtk arwpaksvkf vqgllqnaaa naeakgldat klyvshiqvn 121 qapkqrrrty rahgrinkye sspshielvv tekeeavaka aekkvvrlts rqrgriaaqk 181 riaa // LOCUS NP_012742 679 aa linear PLN 30-JUN-2025 DEFINITION CCAAT displacement transcription factor COY1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012742 VERSION NP_012742.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179745.1 REFERENCE 1 (residues 1 to 679) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 679) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 679) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 679) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08988. Method: conceptual translation. FEATURES Location/Qualifiers source 1..679 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..679 /product="CCAAT displacement transcription factor COY1" /calculated_mol_wt="77383" Region <16..335 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 225..>436 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 409..638 /region_name="CASP_C" /note="CASP C terminal; pfam08172" /db_xref="CDD:462392" CDS 1..679 /gene="COY1" /locus_tag="YKL179C" /coded_by="NM_001179745.1:1..2040" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:31073031]" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:31073031]" /experiment="EXISTENCE:direct assay:GO:0048211 Golgi vesicle docking [PMID:31073031]" /experiment="EXISTENCE:genetic interaction:GO:0000139 Golgi membrane [PMID:12429822]" /experiment="EXISTENCE:genetic interaction:GO:0048193 Golgi vesicle transport [PMID:12429822]" /note="Golgi membrane protein with similarity to mammalian CASP; packaged into COPII vesicles for trafficking between ER and Golgi; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function" /db_xref="GeneID:853675" /db_xref="SGD:S000001662" ORIGIN 1 mdtsvyshal diwakadltn lqreldadvi eikdketlsl nsrkslatet kkfkklepee 61 klnnvnkiik qyqreidnlt qrskfsekvl fdvyeklsea pdpqpllqss leklgkidds 121 kelkekisyl edklakyady etlksrlldl eqssaktlak rltaktqein stweekgrnw 181 kereadllkq ltnvqeqnka leakisknid iegngnedgd qennqkevst riaeynlvtq 241 elettqariy qlekrneels galakatsea eketelhake lklnqlesen allsasyeqe 301 rkstshaine lkeqlnsvva esesyksele tvrrklnnys dynkikeels alkkiefgvn 361 eddsdndirs edkndntfes sllsankklq atlaeyrsks taqeeernel kksvdqlkqq 421 iatlkeanek letdlekven vsphfnetas mmsgvtrqmn nrtshkmspt ssiigipedg 481 elsgnqstil pivtkqrdrf rsrnmdlekq lrqgnsekgk lkleisklkg dntklyerir 541 ylqsynnnna pvnqsterid vesqysrvyd eslhpmanfr qnelnhyknk klsaleklfs 601 sfakvilqnk mtrmvflfyc iglhglvfmm smyvinisgy mtpevgivqs aksssnlngg 661 lggaekvaag vgsvhginr // LOCUS NP_012743 470 aa linear PLN 30-JUN-2025 DEFINITION Ste3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012743 VERSION NP_012743.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179744.1 REFERENCE 1 (residues 1 to 470) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 470) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 470) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 470) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08989. Method: conceptual translation. FEATURES Location/Qualifiers source 1..470 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..470 /product="Ste3p" /calculated_mol_wt="53577" Region 10..289 /region_name="STE3" /note="Pheromone A receptor; pfam02076" /db_xref="CDD:460437" CDS 1..470 /gene="STE3" /locus_tag="YKL178C" /gene_synonym="DAF2" /coded_by="NM_001179744.1:1..1413" /experiment="EXISTENCE:direct assay:GO:0000755 cytogamy [PMID:17369365]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:3006051]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3006051]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:17369365]" /experiment="EXISTENCE:mutant phenotype:GO:0004933 mating-type a-factor pheromone receptor activity [PMID:3006051]" /note="Receptor for a factor pheromone; couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR" /db_xref="GeneID:853677" /db_xref="SGD:S000001661" ORIGIN 1 msyksaiigl cllavillap plawhshtkn ipaiilitwl ltmnltcivd aaiwsdddfl 61 trwdgkgwcd iviklqvgan igiscavtni iynlhtilka dsvlpdlssw tkivkdlvis 121 lftpvmvmgf syllqvfryg iaryngcqnl lsptwittvl ytmwmliwsf vgavyatlvl 181 fvfykkrkdv rdilhctnsg lnltrfarll ifcfiiilvm fpfsvytfvq dlqqveghyt 241 fknthsstiw ntiikfdpgr piyniwlyvl msylvflifg lgsdalhmys kflrsiklgf 301 vldmwkrfid knkekrvgil lnklssrkes rnpfstdsen yistctenys pcvgtpisqa 361 hfyvdyripd dprksqnksk kylfadketd dildeidlke srhipyvtqg qsfddeislg 421 gfskvtldys eklhnsassn fegeslcysp askeensssn ehssentagp // LOCUS NP_012745 828 aa linear PLN 30-JUN-2025 DEFINITION Lst4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012745 VERSION NP_012745.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179742.1 REFERENCE 1 (residues 1 to 828) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 828) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 828) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 828) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 828) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 828) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 828) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08990. Method: conceptual translation. FEATURES Location/Qualifiers source 1..828 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..828 /product="Lst4p" /calculated_mol_wt="93228" Region 118..288 /region_name="Longin_2" /note="Yeast longin domain; pfam18639" /db_xref="CDD:436639" CDS 1..828 /gene="LST4" /locus_tag="YKL176C" /coded_by="NM_001179742.1:1..2487" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:26387955]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26387955]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:26387955]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990877 FNIP-folliculin RagC/D GAP [PMID:26387955]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:26387955]" /experiment="EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:26387955]" /note="Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface" /db_xref="GeneID:853678" /db_xref="SGD:S000001659" ORIGIN 1 mlgnllrnkt sssgfeksse hsdfssvvpn vpvyckaast gttktaagal ldtavnvekp 61 semlsttspp ildhisddlk lklfgsrdip ysrpidtlqn ngglgtdkit sinektyafr 121 iliieeagqm acrnnyrdif dyttskisns meqirpselk eyifgspvrs sdltqcdkir 181 tipnsdlvli trifyythqy nriaislcip rillpvvaes wssisswltq tqkmligflt 241 knrimqentg nysnnsvikl snidirthyp keieimvqtl qkrvipglrs mseiprlfly 301 petfkefvhv wfksifnwie ikdgpklgfl pllmamiisd yrhtirelkt skivilsgnm 361 vvankllfil sallepkykg qitirrenir sdssavsrnk snnnfvdkpe telstltstd 421 nllsrtenns nhnynnsnvs snsigspnfh slrkgwqipn rrnsntsvsv ssseslaevi 481 qpssfksgss slhylsssis sqpgsygswf nkrptisqff qpspslkhne swerlqttag 541 nmqrtsssss lqqatsrlsl ttpqqspsis eydeypwmgt pgspnvgdvs happlvknis 601 ykfplknvel krdcqrisqd dlldeaferi cqpsladlns tyeifpgnss yadilttdsd 661 iddglmnkpl ellpkytmyl thfnnffqlq acpagqeses ritnsmkidl lkadytrsll 721 vslrsrdird valkreftgn nnnnsnqniy denfvgkrky vlkqktrkif scgkigklst 781 slencvnfve nsiksammly ddngidselr dsealrifss lvhycnag // LOCUS NP_012746 503 aa linear PLN 30-JUN-2025 DEFINITION Zn(2+) transporter ZRT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012746 VERSION NP_012746.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179741.1 REFERENCE 1 (residues 1 to 503) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 503) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 503) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 503) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08991. Method: conceptual translation. FEATURES Location/Qualifiers source 1..503 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..503 /product="Zn(2+) transporter ZRT3" /calculated_mol_wt="55272" Region 8..>93 /region_name="ZupT" /note="Zinc transporter ZupT [Inorganic ion transport and metabolism]; COG0428" /db_xref="CDD:440197" Region <321..451 /region_name="ZupT" /note="Zinc transporter ZupT [Inorganic ion transport and metabolism]; COG0428" /db_xref="CDD:440197" CDS 1..503 /gene="ZRT3" /locus_tag="YKL175W" /coded_by="NM_001179741.1:1..1512" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:10856230]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005385 zinc ion transmembrane transporter activity [PMID:10856230]" /experiment="EXISTENCE:mutant phenotype:GO:0006829 zinc ion transport [PMID:10856230]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:10856230]" /note="Vacuolar membrane zinc transporter; transports zinc from storage in vacuole to cytoplasm when needed; transcription induced under conditions of zinc deficiency; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:853679" /db_xref="SGD:S000001658" ORIGIN 1 mekiprwllf slissvlcil galcvpllsv afdskrnsqs klvnyglsls agsmittsly 61 mllprieksn rfkvfpglll giclsfflny lvhafasesl vhcadsgdha tgshihsksh 121 shshshshad shsnfsndhd lenapsehgy atssssvsen dplitkdsdr pqmkkkmsli 181 dlltrrkseg eccdlnkctp llqseqpeyi acvppvikss qsernvphgc egsedngqsd 241 dkdhrglvcv ennigydlen lslyrknfls srhhhssesp enygsnqlsh sfssplgndv 301 tenpaaladt qyhpengsly phhhhletpf skllsigmqt clvlalhkfp egfiifytnr 361 sdsskslgfs iflsltihnf vegfamtlpf ytvfeskwva ilitavlggg sqplgaligy 421 fifkgstprd hepnmdflls vtagfllvig lqmfqtgigf sdghhhhqge gdeemkqshs 481 sgttclkwcc tgvllilasa lft // LOCUS NP_012747 618 aa linear PLN 30-JUN-2025 DEFINITION Tpo5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012747 VERSION NP_012747.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179740.1 REFERENCE 1 (residues 1 to 618) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 618) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 618) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 618) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08992. Method: conceptual translation. FEATURES Location/Qualifiers source 1..618 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..618 /product="Tpo5p" /calculated_mol_wt="69112" Region 59..531 /region_name="AA_permease" /note="Amino acid permease; pfam00324" /db_xref="CDD:366028" CDS 1..618 /gene="TPO5" /locus_tag="YKL174C" /coded_by="NM_001179740.1:1..1857" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15668236]" /experiment="EXISTENCE:mutant phenotype:GO:0015203 polyamine transmembrane transporter activity [PMID:15668236]" /experiment="EXISTENCE:mutant phenotype:GO:0015846 polyamine transport [PMID:15668236]" /note="Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles" /db_xref="GeneID:853680" /db_xref="SGD:S000001657" ORIGIN 1 mpeytlladn irenivhfdp nglfdnlhti vheddsqene eaehfnydqv ldksllsrgs 61 ivglglglms pvlgmctsma iglinggplt imlgflisgv ciwfsslslg eivskfpmel 121 hvgsamlape klklvcswyt gwlmlignwt mstsitfaga qltislilmt nsnliseahl 181 ifytvivfyl vvtvvglvnl kfarfietin kvcvywiiya iifidilllv fhkgkfrslk 241 yalfhfdnnl sgyksaflsf iigfqqsnft lqgfsmlpal adevkvpekd iprgmsnavl 301 lsafsgvifl ipimlilpdn dllftnhkvl pivniftkst dsvvlsfflv llilgnllfs 361 gigsittssr avysfsrdqa ipyydkwtyv epdsqskvpk nsvvlsmiis yflgllalis 421 taafnafiga avlclcsatf iplvlvlftr rrairsapvk irykfgwfin ivsivwllls 481 mvsvclptqv pvtfktmnya lmvyvfcilv itglyfkwgk ynfrlpladd ikapipsdae 541 etvfeledsn vehtlnsgtt vkesvennse egfikvhpks stenpfeene envitdygde 601 hhtaeqefdl addrrydi // LOCUS NP_012748 1008 aa linear PLN 30-JUN-2025 DEFINITION U5 snRNP GTPase SNU114 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012748 VERSION NP_012748.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179739.1 REFERENCE 1 (residues 1 to 1008) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1008) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1008) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1008) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1008) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1008) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1008) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08993. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1008 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1008 /product="U5 snRNP GTPase SNU114" /calculated_mol_wt="113911" Region 121..992 /region_name="PRK13351" /note="elongation factor G-like protein; cl46912" /db_xref="CDD:481252" CDS 1..1008 /gene="SNU114" /locus_tag="YKL173W" /gene_synonym="GIN10" /coded_by="NM_001179739.1:1..3027" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720285|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0030623 U5 snRNA binding [PMID:9848662]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:genetic interaction:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:15911574]" /experiment="EXISTENCE:mutant phenotype:GO:0000244 spliceosomal tri-snRNP complex assembly [PMID:16540695]" /experiment="EXISTENCE:mutant phenotype:GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) [PMID:16540695]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9233818]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:9233818]" /note="GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2" /db_xref="GeneID:853681" /db_xref="SGD:S000001656" ORIGIN 1 megddlfdef gnligvdpfd sdeeesvlde qeqyqtntfe gsgnnneies rqltslgskk 61 elgislehpy gkevevlmet kntqspqtpl vepvtertkl qehtiftqlk knipktrynr 121 dymlsmanip eriinvgvig plhsgktslm dllvidshkr ipdmsknvel gwkplryldn 181 lkqeidrgls iklngstllc tdlesksrmi nfldapghvn fmdetavala asdlvlivid 241 vvegvtfvve qlikqsiknn vamcfvinkl drlildlklp pmdaylklnh iianinsftk 301 gnvfspidnn iifastklgf tftikefvsy yyahsipssk iddfttrlwg svyyhkgnfr 361 tkpfenveky ptfvefilip lykifsyals mekdklknll rsnfrvnlsq ealqydpqpf 421 lkhvlqlifr qqtglvdait rcyqpfelfd nktahlsipg kstpegtlwa hvlktvdygg 481 aewslvriys gllkrgdtvr ildtsqsesr qkrqlhdisk tetsnedede ddetpsceve 541 eigllggryv ypvheahkgq ivlikgissa yiksatlysv kskedmkqlk ffkpldyite 601 avfkivlqpl lprelpklld alnkiskyyp gviikveesg ehvilgngel ymdcllydlr 661 asyakieiki sdpltvfses csnesfasip vsnsisrlge enlpglsisv aaepmdskmi 721 qdlsrntlgk gqncldidgi mdnprklski lrteygwdsl asrnvwsfyn gnvlindtlp 781 deispellsk ykeqiiqgfy wavkegplae epiygvqykl lsisvpsdvn idvmksqiip 841 lmkkacyvgl ltaipillep iyevditvha pllpiveelm kkrrgsriyk tikvagtpll 901 evrgqvpvie sagfetdlrl stnglgmcql yfwhkiwrkv pgdvldkdaf ipklkpapin 961 slsrdfvmkt rrrkgistgg fmsndgptle kyisaelyaq lrenglvp // LOCUS NP_012749 427 aa linear PLN 30-JUN-2025 DEFINITION Ebp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012749 VERSION NP_012749.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179738.1 REFERENCE 1 (residues 1 to 427) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 427) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 427) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 427) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08994. Method: conceptual translation. FEATURES Location/Qualifiers source 1..427 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..427 /product="Ebp2p" /calculated_mol_wt="49603" Region 195..422 /region_name="Ebp2" /note="Eukaryotic rRNA processing protein EBP2; pfam05890" /db_xref="CDD:461770" CDS 1..427 /gene="EBP2" /locus_tag="YKL172W" /coded_by="NM_001179738.1:1..1284" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10849420]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:11583614]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:21822217]" /experiment="EXISTENCE:mutant phenotype:GO:0000280 nuclear division [PMID:15515129]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:10849420]" /note="Protein required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering" /db_xref="GeneID:853682" /db_xref="SGD:S000001655" ORIGIN 1 makgfklkel lshqkeieka eklendlkkk ksqelkkeep tivtasnlkk lekkekkadv 61 kkevaadtee yqsqalskke krklkkelkk mqeqdateaq khmsgdedes gddreeeeee 121 eeeeegrldl eklaksdses eddsesends eededvvake eseekeeqee eqdvplsdve 181 fdsdadvvph hkltvnntka mkhalervql pwkkhsfqeh qsvtsetntd ehikdiyddt 241 erelafykqs ldavlvarde lkrlkvpfkr pldyfaemvk sdehmdkikg klieeasdkk 301 areearrqrq lkkfgkqvqn atlqkrqlek retlekiksl knkrkhneid hsefnvgvee 361 evegkrfdrg rpngkraakn akygqggmkr fkrkndatss advsgfssrk mkgktnrpgk 421 srrarrf // LOCUS NP_012750 928 aa linear PLN 30-JUN-2025 DEFINITION protein kinase NNK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012750 VERSION NP_012750.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179737.1 REFERENCE 1 (residues 1 to 928) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 928) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 928) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 928) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 928) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08995. Method: conceptual translation. FEATURES Location/Qualifiers source 1..928 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..928 /product="protein kinase NNK1" /EC_number="2.7.11.1" /calculated_mol_wt="103826" Region 455..>613 /region_name="PKc" /note="Catalytic domain of Protein Kinases; cd00180" /db_xref="CDD:270622" Site order(455..459,463,476,478,508,525..528,532,534,580,582, 584..585,587,603,606) /site_type="active" /db_xref="CDD:270622" Site order(455..459,463,476,478,508,525..528,532,580,582, 584..585,587,603) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270622" Site order(459,532,534,580,582,584,606) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270622" Site 602..608 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270622" Region <817..864 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Region <821..913 /region_name="Pkinase" /note="Protein kinase domain; pfam00069" /db_xref="CDD:459660" CDS 1..928 /gene="NNK1" /locus_tag="YKL171W" /coded_by="NM_001179737.1:1..2787" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22289182]" /experiment="EXISTENCE:mutant phenotype:GO:0006508 proteolysis [PMID:11595789]" /note="Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm" /db_xref="GeneID:853683" /db_xref="SGD:S000001654" ORIGIN 1 mftsqrqlrq ngspmsssrs sqhssgtasp isdspasnrs ygrdlrglmg idipanepaf 61 nranssdtiy frpkkiykme hehpsrstlv qlqtrsqpdd vassqvnpeg gtddlelgdp 121 cgnqslytig aeyvpdldft klvnewqkst edlyefrssa tpqvqikdsg kgnyelwssp 181 dailtqnklr rdsfsqensd slspedsils rnlhskvkpi plprnsqqif tplsnleaer 241 rssyttssnn nsitqnnkfs faklkyslpt qssavpasfd snasslnflp tttlstlsel 301 qispndmmdl iqklprnfln lpytqrkkvi iehapshdyk ammslvkkfm ltssrsnfsl 361 agfannasvs qatanddnin srntpnnsnd tyvntrplqr srhgsiasqf lssfspsmts 421 iakmnsnpls gsaggsarpd dkgmeilghr lgkiigfgaw giirecfdie tgvgrvikiv 481 kfkghqnikk hvlrevaiwr tlkhnrilpl ldwklddnya myclterind gtlydlvisw 541 defkrskipf aercrltifl slqllsalky mhsktivhgd iklencllqk egkksdwkvf 601 lcdfgmschf dekhvyrndt fdenlssgns hrkrksieqt nlikypttnf lpddrtndfd 661 asenlkyqfe nrkhqpftpk gmvsssshsl khlnqpssss ssnlfhkpas qpqpqhrspf 721 hgrhkttdfs nlepepskyi gslpyaspel lrysdarrsk svemhiydsp dssqseisaa 781 sssssnlssl ssstkasavt nsgvttssps gsstdfpciv splgpasdiw algvmlytml 841 vgklpfnhef eprlrslikv gefdrfslaq vckfdrkkne gtigqglydt vigcltidld 901 krwklkriee vlqnemnlse aihdnngs // LOCUS NP_012751 138 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL14m MRPL38 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012751 VERSION NP_012751.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179736.1 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 138) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08996. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..138 /product="mitochondrial 54S ribosomal protein uL14m MRPL38" /calculated_mol_wt="14773" Region 1..138 /region_name="rplN_bact" /note="ribosomal protein L14, bacterial/organelle; TIGR01067" /db_xref="CDD:273426" CDS 1..138 /gene="MRPL38" /locus_tag="YKL170W" /gene_synonym="uL14m" /coded_by="NM_001179736.1:1..417" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552|PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853684" /db_xref="SGD:S000001653" ORIGIN 1 miflksvikv idnsgaqlae cikvirkgsp kspamvgdri vcviqkakpl tqnitgtant 61 nrvkkgdich aivvrskqrn mcrkdgstva fgdtacvlin kntgeplgtr imandgcvdr 121 tlkdkgynki cslasrvi // LOCUS NP_012753 724 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase KKQ8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012753 VERSION NP_012753.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179734.1 REFERENCE 1 (residues 1 to 724) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 724) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 724) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 724) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08997. On May 22, 2006 this sequence version replaced NP_012753.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..724 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..724 /product="putative serine/threonine protein kinase KKQ8" /EC_number="2.7.11.1" /calculated_mol_wt="82459" Region 418..712 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(418..421,424,426,453,455,497,513..516,563,567..568, 570,580..581) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..724 /gene="KKQ8" /locus_tag="YKL168C" /coded_by="NM_001179734.1:1..2175" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22289182]" /note="Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication" /db_xref="GeneID:853686" /db_xref="SGD:S000001651" ORIGIN 1 mvmqeekkrq qpvtrrvrsf sesfknlfrp prsrdsspin vtripyrsss tspkrssepp 61 rrstvsaqil dpknspirqr sytlkcctpg lshpfrqtgs gasnsptrhr sisgeeqeiv 121 nslpeykrsa shtfhgirrp rsrsssvssc dssngttsss dsqwamdsll ddsdndltpy 181 rgsnkdilks kdrapynyid dynkkalrra tsypnplpsk qfynerlytr rshpdeesle 241 slprfagadv qciieqngfk vyedgshehn iklsgviakl ekgnslpahr qgslsrprlg 301 itlsglfkhh knecdienal sllpnveksq tnhekrtgqs pndsnrsspt qgredylkiv 361 npdaslgsde lklinslssr ihkslqnylq eknlkpaeci geqaptfqdn yghpvglvga 421 gaygevklca rlrnekdspp fetyhdskyi yyavkelkpk pdsdlekfct kitsefiigh 481 slshyhkngk kpapnilnvf diledsssfi evmefcpagd lygmlvgksk lkgrlhplea 541 dcfmkqllhg vkfmhdhgia hcdlkpenil fyphgllkic dfgtssvfqt awerrvhaqk 601 giigsepyva peefvdgeyy dprlidcwsc gvvyitmilg hylwkvasre kdmsydefyk 661 emqrknqfrv feelkhvnse latnrkialy rifqweprkr isvgklldmq wmkstnccli 721 ydst // LOCUS NP_012754 137 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL61 MRP49 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012754 VERSION NP_012754.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179733.1 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 137) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08998. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..137 /product="mitochondrial 54S ribosomal protein mL61 MRP49" /calculated_mol_wt="15890" Region 43..119 /region_name="L51_S25_CI-B8" /note="Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; smart00916" /db_xref="CDD:197984" CDS 1..137 /gene="MRP49" /locus_tag="YKL167C" /gene_synonym="mL61" /coded_by="NM_001179733.1:1..414" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:1544898]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:1544898]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:1544898]" /note="Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation" /db_xref="GeneID:853687" /db_xref="SGD:S000001650" ORIGIN 1 mskvaqqlkf lnkisattrl pqilvdpkky sglrltfqtk nhnghmgarv fwhnylptlq 61 fynprmkfdv iriknedkqk svpckleils hegsvvetid mrnkmhedim kdlldkiehv 121 plpeneiirv gpqesii // LOCUS NP_012755 398 aa linear PLN 30-JUN-2025 DEFINITION cAMP-dependent protein kinase catalytic subunit TPK3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012755 VERSION NP_012755.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179732.1 REFERENCE 1 (residues 1 to 398) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 398) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 398) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 398) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA08999. Method: conceptual translation. FEATURES Location/Qualifiers source 1..398 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..398 /product="cAMP-dependent protein kinase catalytic subunit TPK3" /EC_number="2.7.11.11" /calculated_mol_wt="45846" Region 86..376 /region_name="STKc_PKA_like" /note="Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; cd05580" /db_xref="CDD:270732" Site order(94..100,102,115,117,149,165..168,172,211,213, 215..216,218,228..229,373) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270732" Site order(95..100,102,115,117,127,149,165..166,168,172,174,178, 211,213..216,218,228..229,232,243,245..248,275,279..281, 284..286,288,291,373,376) /site_type="active" /db_xref="CDD:270732" Site order(96,98..99,127..129,172,174,178,211,213..215,232, 243..248,275,279..281,284..286,288,291..292,376) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270732" Site order(98,128..129,131..132,172,174,178,213..215,232, 241..246,249,256..257,275,288..289,292..293,296,376) /site_type="other" /note="regulatory subunit interface [polypeptide binding]" /db_xref="CDD:270732" Site order(228..236,240..248) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270732" CDS 1..398 /gene="TPK3" /locus_tag="YKL166C" /coded_by="NM_001179732.1:1..1197" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:22899713]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:19804918]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:19804918]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:22899713]" /experiment="EXISTENCE:genetic interaction:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0005952 cAMP-dependent protein kinase complex [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:19897478]" /experiment="EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly [PMID:21925385]" /experiment="EXISTENCE:genetic interaction:GO:0010737 protein kinase A signaling [PMID:20133652]" /experiment="EXISTENCE:mutant phenotype:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:19897478]" /experiment="EXISTENCE:mutant phenotype:GO:0070314 G1 to G0 transition [PMID:22899713]" /experiment="EXISTENCE:mutant phenotype:GO:2000766 negative regulation of cytoplasmic translation [PMID:22899713]" /note="cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication" /db_xref="GeneID:853688" /db_xref="SGD:S000001649" ORIGIN 1 myvdpmnnne irklsitakt ettpdnvgqd ipvnahsvhe ecssntpvei ngrnsgklke 61 easagiclvk kpmlqyrdts gkyslsdfqi lrtlgtgsfg rvhlirsnhn grfyalktlk 121 khtivklkqv ehtnderrml sivshpfiir mwgtfqdsqq vfmvmdyieg gelfsllrks 181 qrfpnpvakf yaaevclale ylhskdiiyr dlkpenilld knghikitdf gfakyvpdvt 241 ytlcgtpdyi apevvstkpy nksvdwwsfg vliyemlagy tpfynsntmk tyenilnael 301 kfppffhpda qdllkklitr dlserlgnlq ngsedvknhp wfneviwekl laryietpye 361 ppiqqgqgdt sqfdrypeee fnygiqgedp ymdlmkef // LOCUS NP_012756 919 aa linear PLN 30-JUN-2025 DEFINITION mannose-ethanolamine phosphotransferase MCD4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012756 VERSION NP_012756.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179731.1 REFERENCE 1 (residues 1 to 919) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 919) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 919) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 919) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 919) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 919) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 919) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09000. Method: conceptual translation. FEATURES Location/Qualifiers source 1..919 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..919 /product="mannose-ethanolamine phosphotransferase MCD4" /calculated_mol_wt="105563" Region 46..353 /region_name="GPI_EPT_1" /note="GPI ethanolamine phosphate transferase 1; PIG-N; cd16020" /db_xref="CDD:293744" Site order(57..58,104,224,271..272) /site_type="active" /note="putative active site [active]" /db_xref="CDD:293744" Site order(57,104,224,272) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:293744" Region 442..874 /region_name="PigN" /note="Phosphatidylinositolglycan class N (PIG-N); pfam04987" /db_xref="CDD:461508" CDS 1..919 /gene="MCD4" /locus_tag="YKL165C" /gene_synonym="FSR2; SSU21; ZRG16" /coded_by="NM_001179731.1:1..2760" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:10514566]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10069808|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006506 GPI anchor biosynthetic process [PMID:12023081]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:12023081]" /experiment="EXISTENCE:direct assay:GO:0015867 ATP transport [PMID:12807869]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:16704983|PMID:17311586]" /experiment="EXISTENCE:mutant phenotype:GO:0051377 mannose-ethanolamine phosphotransferase activity [PMID:16704983|PMID:17311586]" /note="Protein involved in GPI anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes; GPI stands for glycosylphosphatidylinositol" /db_xref="GeneID:853690" /db_xref="SGD:S000001648" ORIGIN 1 mwnktrttll avgvlfhlfy lwsifdiyfi splvhgmspy qstptppakr lflivgdglr 61 adttfdkvth pvsgktefla pfirslvmnn atygishtrm ptesrpghva miagfyedvs 121 avtkgwksnp vnfdsffnqs thtysfgspd ilpmfkdgas dpnkvdtwmy dhtfedftqs 181 sieldafvfr hldqlfhnst lnstldyeir qdgnvfflhl lgcdtaghsy rpysaeyydn 241 vkyiddqipi lidkvnkffa ddktafifta dhgmsafgsh gdghpnntrt plvawgagln 301 kpvhnpfpvs dnytenwels sikrndvkqa diaslmsyli gvnypknsvg elpiayidgk 361 esdklaalyn narsileqyl vkqdevidsq ffykeyfkfv ekshshylee ietliqrise 421 genyleqeai tlteelmqit leglhyltty nwrfirtivt fgfvgwiffs fiiflksfil 481 enviddqkas plshavfgsi gillnwilfy qhspfnfymy llfplyfwsy iftnrsvlrs 541 gikeffkgts pwkrvlitis iisvyegivy gffhrwtftl itnilafypf icgvrelsvn 601 ilwiitsvll stftlfdavk iedlnqihla glliilsafy alykihsrin sytraifaiq 661 islvaamlav thrsvislql rqglpresqv agwiiffvsl fvmpilhyrk pnndykvrll 721 iiyltfapsf iiltisfesl fyflftsymv qwieienkik emktqkdenw lqvlrvsvig 781 ffllqvaffg tgnvasissf slesvcrllp ifdpflmgal lmlkliipyg llstclgiln 841 lklnfkdyti ssliismsdi lslnffyllr tegswldigi tisnyclail sslfmlilev 901 lghvllknvi iqdktkktq // LOCUS NP_012757 341 aa linear PLN 30-JUN-2025 DEFINITION beta-1,3-glucan linked protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012757 VERSION NP_012757.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179730.1 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 341) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09001. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..341 /product="beta-1,3-glucan linked protein" /calculated_mol_wt="34491" CDS 1..341 /gene="PIR1" /locus_tag="YKL164C" /gene_synonym="CCW6" /coded_by="NM_001179730.1:1..1026" /experiment="EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:9301021]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:16278454]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460|PMID:9192695]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:11238901]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10407261]" /note="O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle; PIR1 has a paralog, YJL160C, that arose from the whole genome duplication" /db_xref="GeneID:853692" /db_xref="SGD:S000001647" ORIGIN 1 mqykkslvas alvatslaay apkdpwstlt psatykggit dysstfgiav epiattassk 61 akraaaisqi gdgqiqattk ttaaavsqig dgqiqattkt kaaavsqigd gqiqattktt 121 sakttaaavs qigdgqiqat tktkaaavsq igdgqiqatt kttaaavsqi gdgqiqattk 181 ttaaavsqig dgqiqattnt tvapvsqitd gqiqattlts atiipspapa pitngtdpvt 241 aetckssgtl emnlkggilt dgkgrigsiv anrqfqfdgp ppqagaiyaa gwsitpegnl 301 aigdqdtfyq clsgnfynly dehigtqcna vhlqaidlln c // LOCUS NP_012758 325 aa linear PLN 30-JUN-2025 DEFINITION beta-1,3-glucan linked protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012758 VERSION NP_012758.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179729.1 REFERENCE 1 (residues 1 to 325) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 325) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 325) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 325) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09002. Method: conceptual translation. FEATURES Location/Qualifiers source 1..325 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..325 /product="beta-1,3-glucan linked protein" /calculated_mol_wt="32873" CDS 1..325 /gene="PIR3" /locus_tag="YKL163W" /gene_synonym="CCW8" /coded_by="NM_001179729.1:1..978" /experiment="EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:10407261]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9192695|PMID:15781460]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10407261]" /note="O-glycosylated covalently-bound cell wall protein; required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway; coding sequence contains length polymorphisms in different strains; PIR3 has a paralog, HSP150, that arose from the whole genome duplication" /db_xref="GeneID:853693" /db_xref="SGD:S000001646" ORIGIN 1 mqykkplvvs alaatslaay apkdpwstlt psatykggit dysssfgiai eavatsassv 61 asskakraas qigdgqvqaa tttaavskks taaavsqitd gqvqaaksta aavsqitdgq 121 vqaakstaaa vsqitdgqvq aakstaaavs qitdgqvqaa kstaaaasqi sdgqvqatts 181 tkaaasqitd gqiqasktts gasqvsdgqv qataevkdan dpvdvvscnn nstlsmslsk 241 giltdrkgri gsivanrqfq fdgpppqaga iyaagwsitp egnlalgdqd tfyqclsgdf 301 ynlydkhigs qchevylqai dlidc // LOCUS NP_012760 402 aa linear PLN 30-JUN-2025 DEFINITION type II protein arginine methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012760 VERSION NP_012760.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179728.1 REFERENCE 1 (residues 1 to 402) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 402) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 402) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 402) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 402) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09003. Method: conceptual translation. FEATURES Location/Qualifiers source 1..402 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..402 /product="type II protein arginine methyltransferase" /EC_number="2.1.1.320" /calculated_mol_wt="46378" Region 91..352 /region_name="Methyltransf_28" /note="Putative S-adenosyl-L-methionine-dependent methyltransferase; pfam02636" /db_xref="CDD:460634" CDS 1..402 /locus_tag="YKL162C" /coded_by="NM_001179728.1:1..1209" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion" /db_xref="GeneID:853695" /db_xref="SGD:S000001645" ORIGIN 1 mmkrlhplri qvhlksdypl ftfeqllstn girrgqtari slkdyiewqn fpnimkrenf 61 ftqrkpvttt akeepfsfdn ildcepqfsk clakwllvny klndypyydl nivniytdlp 121 qaiqicknlm sylkstlsdn mfqkikyfmv plykcdkips klldgipgsv slvqdypvsp 181 yflqkkfhie dpiqilmlnd vikytthdlv ryssddkgwq qcfvdinkng qksksfdsai 241 dyscelaleq mfndrshvsp gkelyiptkl ieilmtiknn ipehrlfivd tpqrssptii 301 sllkslispr ptgssqivqp ysdsifsdkr sgricfmtdf lqlqniyngi nsssssceve 361 dvadfvekwi spserstlss qngnrpqled iknsslavlh st // LOCUS NP_012761 433 aa linear PLN 30-JUN-2025 DEFINITION putative protein kinase KDX1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012761 VERSION NP_012761.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179727.1 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 433) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09004. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..433 /product="putative protein kinase KDX1" /EC_number="2.7.11.1" /calculated_mol_wt="49502" Region 22..355 /region_name="STKc_MPK1" /note="Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; cd07857" /db_xref="CDD:173750" Site order(29..32,34..35,37,52,54,71,86,108..111,114,116..117, 153,155,157..158,160,170..171,174,190,192..195,197,235) /site_type="active" /db_xref="CDD:173750" Site order(29..32,34..35,37,52,54,86,108..111,114,117,155, 157..158,160,170..171) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:173750" Site order(71,116,153,155,174,190,192..195,197,235) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:173750" Site order(83,112..113,118,129,132,139,161..165,321,323,326) /site_type="other" /note="KIM docking site [polypeptide binding]" /db_xref="CDD:173750" Site 170..197 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:173750" CDS 1..433 /gene="KDX1" /locus_tag="YKL161C" /gene_synonym="MLP1" /coded_by="NM_001179727.1:1..1302" /note="Protein kinase; implicated in Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p; KDX1 has a paralog, SLT2, that arose from the whole genome duplication" /db_xref="GeneID:853696" /db_xref="SGD:S000001644" ORIGIN 1 matdtercif rafgqdfiln khfhltgkig rgshslicss tytesneeth vairkipnaf 61 gnklsckrtl relkllrhlr ghpnivwlfd tdivfypnga lngvylyeel mecdlsqiir 121 seqrledahf qsfiyqilca lkyihsanvl hcdlkpknll vnsdcqlkic nfglscsyse 181 nhkvndgfik gyitsiwyka peillnyqec tkavdiwstg cilaellgrk pmfegkdyvd 241 hlnhilqilg tppeetlqei asqkvynyif qfgnipgrsf esilpganpe alellkkmle 301 fdpkkritve dalehpylsm whdideefsc qktfrfefeh iesmaelgne vikevfdfrk 361 vvrkhpisgd spssslsled aipqevvqvh psrkvlpsys pefsyvsqlp sltttqpyqn 421 lmgissnsfq gvn // LOCUS NP_012762 145 aa linear PLN 30-JUN-2025 DEFINITION Elf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012762 VERSION NP_012762.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179726.1 REFERENCE 1 (residues 1 to 145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 145) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09005. Method: conceptual translation. FEATURES Location/Qualifiers source 1..145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..145 /product="Elf1p" /calculated_mol_wt="16026" Region 2..79 /region_name="Elf1" /note="Transcription elongation factor Elf1 like; pfam05129" /db_xref="CDD:461556" CDS 1..145 /gene="ELF1" /locus_tag="YKL160W" /coded_by="NM_001179726.1:1..438" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:20818391]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:19159085]" /experiment="EXISTENCE:direct assay:GO:0008023 transcription elongation factor complex [PMID:20818391]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:16260625]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:16260625]" /experiment="EXISTENCE:mutant phenotype:GO:0045815 transcription initiation-coupled chromatin remodeling [PMID:16260625]" /note="Transcription elongation factor with a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression" /db_xref="GeneID:853697" /db_xref="SGD:S000001643" ORIGIN 1 mgkrkkstrk ptkrlvqkld tkfnclfcnh eksvsctldk knsigtlsck icgqsfqtri 61 nslsqpvdvy sdwfdaveev nsgrgsdtdd gdegsdsdye sdseqdaktq ndgeidsdee 121 evdsdeerig qvkrgrgalv dsdde // LOCUS NP_012763 211 aa linear PLN 30-JUN-2025 DEFINITION Rcn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012763 VERSION NP_012763.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179725.1 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 211) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09006. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..211 /product="Rcn1p" /calculated_mol_wt="24004" Region 17..201 /region_name="Calcipressin" /note="pfam04847" /db_xref="CDD:282674" CDS 1..211 /gene="RCN1" /locus_tag="YKL159C" /coded_by="NM_001179725.1:1..636" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:10887154]" /experiment="EXISTENCE:direct assay:GO:0030346 protein phosphatase 2B binding [PMID:10887154]" /experiment="EXISTENCE:mutant phenotype:GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity [PMID:10887154]" /experiment="EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:17954914]" /note="Noncompetitive calcineurin inhibitor involved in calcium-mediated signaling; homolog of human DSCR1, a regulator of calcineurin (RCAN) located in the Down Syndrome candidate region on chromosome 21" /db_xref="GeneID:853698" /db_xref="SGD:S000001642" ORIGIN 1 mgniitdtii itsdkcdivd ndnveriqvw lsknilrkfq ineneplqli ilkrfkrill 61 icpshdisqh vmdasralem enfnfsyslq dgqrnltkqy lkvpesekmf lisppasppp 121 efdfskceda pqrhiqshiq qdqqqrleas qllpnnpdkn nngtftllks kvgaitidrc 181 ptndgngqmq ladhvktafp pksifdtddd d // LOCUS NP_012765 952 aa linear PLN 30-JUN-2025 DEFINITION metallo-aminopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012765 VERSION NP_012765.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179723.2 REFERENCE 1 (residues 1 to 952) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 952) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 952) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 952) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 952) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 952) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 952) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09007. On Apr 26, 2011 this sequence version replaced NP_012765.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..952 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..952 /product="metallo-aminopeptidase" /calculated_mol_wt="107624" Region 109..543 /region_name="M1_APN-Q_like" /note="Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1); cd09601" /db_xref="CDD:341064" Site order(226,228,360..363,396..397,400,419,423,477,482) /site_type="active" /db_xref="CDD:341064" Region 614..928 /region_name="ERAP1_C" /note="ERAP1-like C-terminal domain; pfam11838" /db_xref="CDD:463368" CDS 1..952 /gene="APE2" /locus_tag="YKL157W" /gene_synonym="LAP1; YKL158W" /coded_by="NM_001179723.2:1..2859" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:383482]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:383482]" /experiment="EXISTENCE:direct assay:GO:0043171 peptide catabolic process [PMID:6352682]" /experiment="EXISTENCE:direct assay:GO:0070006 metalloaminopeptidase activity [PMID:6352682]" /experiment="EXISTENCE:mutant phenotype:GO:0043171 peptide catabolic process [PMID:3286257]" /note="Aminopeptidase yscII; may have role in obtaining leucine from dipeptide substrates; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; APE2 has a paralog, AAP1, that arose from the whole genome duplication" /db_xref="GeneID:853699" /db_xref="SGD:S000001640" ORIGIN 1 mpivrwlllk savrgsslig kahpclrsia ahprylsnvy sppagvsrsl rinvmwkqsk 61 ltpprfvkim nrrplftets hacakcqkts qllnktpnre ilpdnvvplh ydltvepdfk 121 tfkfegsvki elkinnpaid tvtlntvdtd ihsakigdvt sseiiseeeq qvttfafpkg 181 tmssfkgnaf ldikftgiln dnmagfyrak yedkltgetk ymattqmept darrafpcfd 241 epnlkasfai tlvsdpslth lsnmdvkney vkdgkkvtlf nttpkmstyl vafivaelky 301 vesknfripv rvyatpgnek hgqfaadlta ktlaffektf giqyplpkmd nvavhefsag 361 amenwglvty rvvdllldkd nstldriqrv aevvqhelah qwfgnlvtmd wweglwlneg 421 fatwmswysc nefqpewkvw eqyvtdtlqh alsldslrss hpievpvkka deinqifdai 481 syskgasllr miskwlgeet fikgvsqyln kfkygnakte dlwdaladas gkdvrsvmni 541 wtkkvgfpvi svsedgngki tfrqnrylst advkpdedkt iypvflalkt kngvdssvvl 601 sersktiele dptffkvnse qsgiyitsyt derwaklgqq adllsvedrv glvadvktls 661 asgytsttnf lnlvskwnne ksfvvwdqii nsissmkstw lfepketqda ldnftkqlis 721 gmthhlgwef kssdsfstqr lkvtmfgaac aardadveka alkmftdycs gnkeaipali 781 kpivfntvar vggaenyekv ykiyldpisn deklaalrsl grfkepklle rtlgylfdgt 841 vlnqdiyipm qgmrahqegv ealwnwvkkn wdelvkrlpp glsmlgsvvt lgtsgftsmq 901 kideikkffa tkstkgfdqs laqsldtits kaqwvnrdrd vvnkylkeng yy // LOCUS NP_012766 82 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS27 RPS27A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012766 VERSION NP_012766.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179722.1 REFERENCE 1 (residues 1 to 82) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 82) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 82) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 82) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 82) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09008. Method: conceptual translation. FEATURES Location/Qualifiers source 1..82 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..82 /product="40S ribosomal protein eS27 RPS27A" /calculated_mol_wt="8748" Region 5..82 /region_name="Ribosomal_S27e" /note="Ribosomal protein S27; cl00897" /db_xref="CDD:445165" CDS 1..82 /gene="RPS27A" /locus_tag="YKL156W" /coded_by="NM_001179722.1:1..249" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:9271380]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S27, no bacterial homolog; RPS27A has a paralog, RPS27B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853700" /db_xref="SGD:S000001639" ORIGIN 1 mvlvqdllhp taasearkhk lktlvqgprs yfldvkcpgc lnittvfsha qtavtcescs 61 tilctptggk aklsegtsfr rk // LOCUS NP_012767 628 aa linear PLN 30-JUN-2025 DEFINITION tRNA methyltransferase RSM22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012767 VERSION NP_012767.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179721.1 REFERENCE 1 (residues 1 to 628) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 628) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 628) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 628) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09009. Method: conceptual translation. FEATURES Location/Qualifiers source 1..628 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..628 /product="tRNA methyltransferase RSM22" /calculated_mol_wt="72059" Region 127..545 /region_name="AdoMet_MTases" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl17173" /db_xref="CDD:473071" CDS 1..628 /gene="RSM22" /locus_tag="YKL155C" /coded_by="NM_001179721.1:1..1887" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent RNA methyltransferase" /db_xref="GeneID:853701" /db_xref="SGD:S000001638" ORIGIN 1 mmkrcfsilp qnvrfsskft slnlpkldla dfidsnkrgi nvlpsyrdet asttqatnsk 61 elrllsktlq gqsyrdqlel npdvskainn nimavhipnn lrrvatnyyk eiqepnslhr 121 pcrtkmevda hiasiflqny gsifqslkel qkrvgpdnfk pqrildvgyg patgivalnd 181 ilgpnyrpdl kdavilgnae mqerakiils rqlnevvdtv eenvstekeq etdrrnknfq 241 edehigevmt kkinimtnlr ssipaskeyd liilthqllh dgnqfpiqvd eniehylnil 301 apgghiviie rgnpmgfeii ararqitlrp enfpdefgki prpwsrgvtv rgkkdaelgn 361 issnyflkvi apcphqrkcp lqvgnpnfyt hkegkdlkfc nfqksikrpk fsielkkgkl 421 latswdgsqg nasrlkgtgr rngrdyeiln ysylifersh kdentlkeik klrnenvngk 481 ydigslgddt qnswpriind pvkrkghvmm dlcapsgele kwtvsrsfsk qiyhdarksk 541 kgdlwasaak tqikglgdln vkkfhkleke rikqlkkeer qkarkamesy neledslqfd 601 dhqfsnfevm kklstfhgnd flqhvnrk // LOCUS NP_012768 244 aa linear PLN 30-JUN-2025 DEFINITION Signal recognition particle receptor subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_012768 VERSION NP_012768.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179720.1 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 244) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09010. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..244 /product="Signal recognition particle receptor subunit beta" /calculated_mol_wt="26843" Region 36..221 /region_name="SRPRB" /note="Signal recognition particle receptor beta subunit; pfam09439" /db_xref="CDD:462797" CDS 1..244 /gene="SRP102" /locus_tag="YKL154W" /coded_by="NM_001179720.1:1..735" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9679135]" /experiment="EXISTENCE:mutant phenotype:GO:0005047 signal recognition particle binding [PMID:9679135]" /experiment="EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:9679135]" /experiment="EXISTENCE:physical interaction:GO:0005785 signal recognition particle receptor complex [PMID:9679135]" /note="Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane" /db_xref="GeneID:853702" /db_xref="SGD:S000001637" ORIGIN 1 mlsntliiac llvigttial iavqkasskt gikqksyqps iiiagpqnsg ktslltlltt 61 dsvrptvvsq eplsaadydg sgvtlvdfpg hvklryklsd ylktrakfvk glifmvdstv 121 dpkkltttae flvdilsite sscengidil iacnkselft arppskikda leseiqkvie 181 rrkkslneve rkineedyae ntldvlqstd gfkfanleas vvafegsink rkisqwrewi 241 dekl // LOCUS NP_012770 247 aa linear PLN 30-JUN-2025 DEFINITION phosphoglycerate mutase GPM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012770 VERSION NP_012770.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179718.1 REFERENCE 1 (residues 1 to 247) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 247) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 247) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 247) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09011. Method: conceptual translation. FEATURES Location/Qualifiers source 1..247 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..247 /product="phosphoglycerate mutase GPM1" /EC_number="5.4.2.11" /calculated_mol_wt="27477" Region 2..231 /region_name="GpmA" /note="Phosphoglycerate mutase (BPG-dependent) [Carbohydrate transport and metabolism]; COG0588" /db_xref="CDD:440353" CDS 1..247 /gene="GPM1" /locus_tag="YKL152C" /coded_by="NM_001179718.1:1..744" /experiment="EXISTENCE:direct assay:GO:0004619 phosphoglycerate mutase activity [PMID:1386023]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:3332961]" /experiment="EXISTENCE:mutant phenotype:GO:0004619 phosphoglycerate mutase activity [PMID:3033435]" /experiment="EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:3033435]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:11015729]" /note="Tetrameric phosphoglycerate mutase; mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis" /db_xref="GeneID:853705" /db_xref="SGD:S000001635" ORIGIN 1 mpklvlvrhg qsewneknlf tgwvdvklsa kgqqeaarag ellkekkvyp dvlytsklsr 61 aiqtaniale kadrlwipvn rswrlnerhy gdlqgkdkae tlkkfgeekf ntyrrsfdvp 121 pppidasspf sqkgderyky vdpnvlpete slalvidrll pywqdviakd llsgktvmia 181 ahgnslrglv khlegisdad iaklniptgi plvfeldenl kpskpsyyld peaaaagaaa 241 vanqgkk // LOCUS NP_012771 337 aa linear PLN 30-JUN-2025 DEFINITION NADHX dehydratase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012771 VERSION NP_012771.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179717.1 REFERENCE 1 (residues 1 to 337) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 337) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 337) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 337) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09012. Method: conceptual translation. FEATURES Location/Qualifiers source 1..337 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..337 /product="NADHX dehydratase" /EC_number="4.2.1.93" /calculated_mol_wt="37226" Region 8..309 /region_name="yjeF_cterm" /note="yjeF C-terminal region, hydroxyethylthiazole kinase-related; TIGR00196" /db_xref="CDD:272955" Site order(50,247,250) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:238576" Site order(182,218,248..249,252,305) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:238576" CDS 1..337 /gene="NNR2" /locus_tag="YKL151C" /coded_by="NM_001179717.1:1..1014" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0046496 nicotinamide nucleotide metabolic process [PMID:21994945]" /experiment="EXISTENCE:direct assay:GO:0047453 ATP-dependent NAD(P)H-hydrate dehydratase activity [PMID:21994945]" /note="Widely-conserved NADHX dehydratase; converts (S)-NADHX to NADH in ATP-dependent manner; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; downstream intergenic region drives antisense expression and mediates coordinated regulation of YKL151C and GPM1 phosphoglycerate mutase; protein abundance increases in response to DNA replication stress; homolog of Carkd in mammals and C-terminus of YjeF in E.coli" /db_xref="GeneID:853706" /db_xref="SGD:S000001634" ORIGIN 1 mlaelshrel iklaqkrcip pllpkfhkgq sggrvciigg cedytgapyf sanatalmgc 61 dlthviceyn agtviksytp nlmvhpylrm sntkldvdmd eqrkkinsll drihvvvigp 121 glgrdplmlk sikdiiryil ekhegkiplv idadglflvt qdsevkemlk sypkgrvilt 181 pnvvefkrlc daigkkgdsh semgsliaqe lncivvekgq sdkifspdse kdmltnseeg 241 snkrvggqgd tltgaiscml afsramydfk iceqeekges sndkplknwv dyamlscyag 301 ctitrecsrl gfkakgramq ttdlndrvge vfaklfg // LOCUS NP_012772 302 aa linear PLN 30-JUN-2025 DEFINITION cytochrome-b5 reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012772 VERSION NP_012772.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179716.1 REFERENCE 1 (residues 1 to 302) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 302) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 302) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 302) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09013. Method: conceptual translation. FEATURES Location/Qualifiers source 1..302 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..302 /product="cytochrome-b5 reductase" /EC_number="1.6.2.2" /calculated_mol_wt="34007" Region 56..302 /region_name="cyt_b5_reduct_like" /note="Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a...; cd06183" /db_xref="CDD:99780" Site order(89,104..107,121..123,125,127..131,169,172..173,302) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99780" Site order(104,106..107) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99780" Site order(123,125,169..170,196..198,229,241,264..268) /site_type="other" /note="NAD binding pocket [chemical binding]" /db_xref="CDD:99780" Site order(128,131,134,140,148,150) /site_type="other" /note="phosphate binding motif [ion binding]" /db_xref="CDD:99780" Site order(164,168..171,173) /site_type="other" /note="beta-alpha-beta structure motif" /db_xref="CDD:99780" CDS 1..302 /gene="MCR1" /locus_tag="YKL150W" /coded_by="NM_001179716.1:1..909" /experiment="EXISTENCE:direct assay:GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H [PMID:8001120]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:16689936|PMID:8001120]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:8001120]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:10622712]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11420140]" /note="Mitochondrial NADH-cytochrome b5 reductase; involved in ergosterol biosynthesis" /db_xref="GeneID:853707" /db_xref="SGD:S000001633" ORIGIN 1 mfsrlsrshs kalpialgtv aiaaatafyf anrnqhsfvf nesnkvfkgd dkwidlpisk 61 ieeeshdtrr ftfklpteds emglvlasal fakfvtpkgs nvvrpytpvs dlsqkghfql 121 vvkhyeggkm tshlfglkpn dtvsfkgpim kwkwqpnqfk sitllgagtg inplyqlahh 181 ivenpndktk vnllygnktp qdillrkeld alkekypdkf nvtyfvddkq ddqdfdgeis 241 fiskdfiqeh vpgpkesthl fvcgpppfmn aysgekkspk dqgeligiln nlgyskdqvf 301 kf // LOCUS NP_012773 405 aa linear PLN 30-JUN-2025 DEFINITION RNA lariat debranching enzyme [Saccharomyces cerevisiae S288C]. ACCESSION NP_012773 VERSION NP_012773.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179715.1 REFERENCE 1 (residues 1 to 405) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 405) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 405) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 405) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09014. Method: conceptual translation. FEATURES Location/Qualifiers source 1..405 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..405 /product="RNA lariat debranching enzyme" /calculated_mol_wt="47610" Region 6..309 /region_name="MPP_Dbr1_N" /note="Dbr1 RNA lariat debranching enzyme, N-terminal metallophosphatase domain; cd00844" /db_xref="CDD:277322" Site order(11,13,40,85..86,179,231,233,251) /site_type="active" /db_xref="CDD:277322" Site order(40,85,179,231) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277322" Region 293..>354 /region_name="DBR1" /note="Lariat debranching enzyme, C-terminal domain; pfam05011" /db_xref="CDD:461518" CDS 1..405 /gene="DBR1" /locus_tag="YKL149C" /gene_synonym="PRP26" /coded_by="NM_001179715.1:1..1218" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:1850323]" /experiment="EXISTENCE:direct assay:GO:0006401 RNA catabolic process [PMID:1850323]" /experiment="EXISTENCE:direct assay:GO:0008419 RNA lariat debranching enzyme activity [PMID:1850323]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:24919400]" /experiment="EXISTENCE:mutant phenotype:GO:0006401 RNA catabolic process [PMID:1850323]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]" /experiment="EXISTENCE:mutant phenotype:GO:0008419 RNA lariat debranching enzyme activity [PMID:1850323]" /experiment="EXISTENCE:mutant phenotype:GO:0016074 sno(s)RNA metabolic process [PMID:9740128]" /experiment="EXISTENCE:mutant phenotype:GO:0032197 retrotransposition [PMID:10652222]" /note="RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant" /db_xref="GeneID:853708" /db_xref="SGD:S000001632" ORIGIN 1 mtklriavqg cchgqlnqiy kevsrihakt pidlliilgd fqsirdgqdf ksiaippkyq 61 rlgdfisyyn neieapvpti figgnhesmr hlmllphggy vaknifymgy snviwfkgir 121 igslsgiwke wdfnkqrpdw ndlennnwka nirnlyhvri sdiaplfmik hridimlshd 181 wpngvvyhgd tkhllklkpf feqdikegkl gspvtwqllr dlrpqwwlsa hlhvrfmasi 241 khnkrshepp nkstsktkkn nneidldlss dedersgimn cqeeneydsk ygetrflald 301 kclprrrwle ileiepdtsh aswkdenhrm fwdpefinnl vicqknknll snkpfnsvnw 361 ielsqsnree grdidwenya ipaytldiqk devrqtkafi skfmt // LOCUS NP_012774 640 aa linear PLN 30-JUN-2025 DEFINITION succinate dehydrogenase flavoprotein subunit SDH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012774 VERSION NP_012774.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179714.1 REFERENCE 1 (residues 1 to 640) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 640) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 640) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 640) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09015. Method: conceptual translation. FEATURES Location/Qualifiers source 1..640 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..640 /product="succinate dehydrogenase flavoprotein subunit SDH1" /EC_number="1.3.5.1" /calculated_mol_wt="70099" Region 21..640 /region_name="FAD_binding_2" /note="FAD binding domain; cl46878" /db_xref="CDD:481218" CDS 1..640 /gene="SDH1" /locus_tag="YKL148C" /coded_by="NM_001179714.1:1..1923" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:2826438|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006121 mitochondrial electron transport, succinate to ubiquinone [PMID:2826438]" /experiment="EXISTENCE:direct assay:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:13445213]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:1939170]" /experiment="EXISTENCE:direct assay:GO:0045273 respiratory chain complex II (succinate dehydrogenase) [PMID:9822678]" /experiment="EXISTENCE:direct assay:GO:0050660 flavin adenine dinucleotide binding [PMID:18279395]" /experiment="EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:16232921]" /experiment="EXISTENCE:genetic interaction:GO:0045333 cellular respiration [PMID:9730279|PMID:16232921]" /experiment="EXISTENCE:mutant phenotype:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:9730279|PMID:197391|PMID:16232921]" /experiment="EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:9730279|PMID:16232921]" /experiment="EXISTENCE:mutant phenotype:GO:0050660 flavin adenine dinucleotide binding [PMID:1939170]" /note="Flavoprotein subunit of succinate dehydrogenase; couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; FAD binding to Sdh1p is required for the assembly of the succinate dehydrogenase subunits; mutations in human ortholog SDHA are associated with Leigh syndrome and predisposition to several cancers" /db_xref="GeneID:853709" /db_xref="SGD:S000001631" ORIGIN 1 mlslkksals kltllrntrt ftssalvrqt qgsvngsasr sadgkyhiid heydcvviga 61 ggaglraafg laeagyktac isklfptrsh tvaaqggina algnmhkdnw kwhmydtvkg 121 sdwlgdqdsi hymtreapks iielehygvp fsrtengkiy qrafggqtke ygkgaqayrt 181 cavadrtgha llhtlygqal rhdthffiey faldllthng evvgviaynq edgtihrfra 241 hktiiatggy grayfsctsa htctgdgnam vsragfplqd lefvqfhpsg iygsgclite 301 gargeggflv nsegerfmer yaptakdlac rdvvsraitm eiregrgvgk kkdhmylqls 361 hlppevlker lpgisetaai fagvdvtkep ipiiptvhyn mggiptkwng ealtideetg 421 edkvipglma cgeaacvsvh ganrlgansl ldlvvfgrav ahtvadtlqp glphkplpsd 481 lgkesianld klrnangsrs taeirmnmkq tmqkdvsvfr tqssldegvr nitavektfd 541 dvkttdrsmi wnsdlvetle lqnlltcasq tavsaanrke srgaharedy pnrddehwmk 601 htlswqkdva apvtlkyrrv idhtldekec psvpptvray // LOCUS NP_012776 692 aa linear PLN 30-JUN-2025 DEFINITION Avt3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012776 VERSION NP_012776.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179712.1 REFERENCE 1 (residues 1 to 692) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 692) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 692) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 692) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09016. Method: conceptual translation. FEATURES Location/Qualifiers source 1..692 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..692 /product="Avt3p" /calculated_mol_wt="75329" Region 295..687 /region_name="Aa_trans" /note="Transmembrane amino acid transporter protein; pfam01490" /db_xref="CDD:279788" CDS 1..692 /gene="AVT3" /locus_tag="YKL146W" /coded_by="NM_001179712.1:1..2079" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:27246536]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:genetic interaction:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:genetic interaction:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:genetic interaction:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015824 proline transport [PMID:27246536]" /experiment="EXISTENCE:mutant phenotype:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]" /note="Vacuolar transporter; exports large neutral amino acids from vacuole; targeted to vacuole via AP-3 pathway; member of family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters" /db_xref="GeneID:853710" /db_xref="SGD:S000001629" ORIGIN 1 mngkevssgs grtqsnnnkk nnnggstgis hasgspltdg nggnsngnsr srsrsrkssg 61 ttggllkkpp llvnneavha svpdashtsc nngtlevsin npephvvdav arhlirnpsn 121 slqlqggdit rdlykwtndh psspsqyqyp sqpalstsip sqapsfsnrk rsmsfsaasi 181 assshlnnns eangnplaai glapapmthe eirapggfrr sfiiqkrrkh nvdapipnff 241 trnfiefltl yghfagedls eeeeeeeete eepeeealet estqlvsreh grhphksstv 301 kavllllksf vgtgvlflpk afhnggwgfs alcllscali sygcfvslit tkdkvgvdgy 361 gdmgrilygp kmkfailssi alsqigfsaa ytvftatnlq vfsenffhlk pgsislatyi 421 faqvlifvpl sltrniakls gtaliadlfi llglvyvyvy siyyiavngv asdtmlmfnk 481 adwslfigta iftfegigll ipiqesmkhp khfrpslsav mcivavifis cgllcyaafg 541 sdvktvvlln fpqdtsytlt vqllyalail lstplqlfpa irilenwtfp snasgkynpk 601 vkwlknyfrc aivvltsila wvgandldkf vslvgsfaci pliyiyppll hykasilsgt 661 srarllldli vivfgvavma ytswqtikmw sq // LOCUS NP_012777 467 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle base subunit RPT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012777 VERSION NP_012777.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179711.1 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 467) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09017. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..467 /product="proteasome regulatory particle base subunit RPT1" /calculated_mol_wt="51852" Region 154..466 /region_name="PRK03992" /note="proteasome-activating nucleotidase; Provisional" /db_xref="CDD:179699" CDS 1..467 /gene="RPT1" /locus_tag="YKL145W" /gene_synonym="CIM5; YTA3" /coded_by="NM_001179711.1:1..1404" /experiment="EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626]" /experiment="EXISTENCE:direct assay:GO:0045732 positive regulation of protein catabolic process [PMID:15135049]" /experiment="EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:19843524]" /experiment="EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19412160]" /experiment="EXISTENCE:physical interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15135049]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:10688918]" /note="ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance" /db_xref="GeneID:853712" /db_xref="SGD:S000001628" ORIGIN 1 mppkedweky kapledddkk pdddkivplt egdiqvlksy gaapyaaklk qtendlkdie 61 arikekagvk esdtglapsh lwdimgdrqr lgeehplqva rctkiikgng esdetttdnn 121 nsgnsnsnsn qqstdadedd edakyvinlk qiakfvvglg ervsptdiee gmrvgvdrsk 181 ynielplppr idpsvtmmtv eekpdvtysd vggckdqiek lrevvelpll sperfatlgi 241 dppkgillyg ppgtgktlca ravanrtdat firvigselv qkyvgegarm vrelfemart 301 kkaciiffde idavggarfd dgaggdnevq rtmlelitql dgfdprgnik vmfatnrpnt 361 ldpallrpgr idrkvefslp dlegranifr ihsksmsver girwelisrl cpnstgaelr 421 svcteagmfa irarrkvate kdflkavdkv isgykkfsst srymqyn // LOCUS NP_012778 212 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase III subunit RPC25 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012778 VERSION NP_012778.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179710.1 REFERENCE 1 (residues 1 to 212) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 212) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 212) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 212) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09018. Method: conceptual translation. FEATURES Location/Qualifiers source 1..212 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..212 /product="DNA-directed RNA polymerase III subunit RPC25" /calculated_mol_wt="24195" Region 1..184 /region_name="rpoE" /note="DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form; TIGR00448" /db_xref="CDD:129540" CDS 1..212 /gene="RPC25" /locus_tag="YKL144C" /gene_synonym="YKL1" /coded_by="NM_001179710.1:1..639" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0006384 transcription initiation at RNA polymerase III promoter [PMID:15612920]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:15612920|PMID:8065349]" /note="RNA polymerase III subunit C25; required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p" /db_xref="GeneID:853713" /db_xref="SGD:S000001627" ORIGIN 1 mfilskiadl vrippdqfhr dtisaithql nnkfankiip nvglcitiyd lltveegqlk 61 pgdgssyinv tfravvfkpf lgeivtgwis kctaegikvs llgifddifi pqnmlfegcy 121 ytpeesawiw pmdeetklyf dvnekirfri erevfvdvkp kspkerelee raqleneieg 181 kneetpqnek ppayallgsc qtdgmglvsw we // LOCUS NP_012779 463 aa linear PLN 30-JUN-2025 DEFINITION ribosome biogenesis protein LTV1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012779 VERSION NP_012779.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179709.1 REFERENCE 1 (residues 1 to 463) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 463) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 463) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 463) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09019. Method: conceptual translation. FEATURES Location/Qualifiers source 1..463 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..463 /product="ribosome biogenesis protein LTV1" /calculated_mol_wt="53259" Region 8..408 /region_name="LTV" /note="Low temperature viability protein; pfam04180" /db_xref="CDD:461211" CDS 1..463 /gene="LTV1" /locus_tag="YKL143W" /gene_synonym="YKL2" /coded_by="NM_001179709.1:1..1392" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16888326]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:16888326]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:16738661]" /experiment="EXISTENCE:direct assay:GO:0031902 late endosome membrane [PMID:16732272]" /experiment="EXISTENCE:direct assay:GO:0071986 Ragulator complex [PMID:16732272]" /experiment="EXISTENCE:genetic interaction:GO:0000056 ribosomal small subunit export from nucleus [PMID:16888326]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:16888326]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /note="Subunit of the EGO/GSE complex; the vacuolar/endosomal membrane associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from the endosome to the plasma membrane; required for ribosomal small subunit export from nucleus; required for growth at low temperature" /db_xref="GeneID:853714" /db_xref="SGD:S000001626" ORIGIN 1 mskkfsskns qryvvvhrph ddpsfydtda sahvlvpvsn pnktspeadl rkkdvsstkp 61 kgrrahvgea alyginfdds eydytqhlkp igldpensif iaskgneqkv ekkniedlfi 121 epkyrrdeie kddalpvfqr gmakpeyllh qqdttdeirg fkpdmnpalr evlealedea 181 yvvnddvvve diskktqlqg dnygeeeked difaqllgsg eakdedefed efdewdidnv 241 enfedenyvk emaqfdnien ledlenidyq advrrfqkdn silekhnsdd efsnagldsv 301 npseeedvlg elpsiqdksk tgkkkrksrq kkgamsdvsg fsmsssaiar tetmtvlddq 361 ydqiingyen yeeeleedee qnyqpfdmsa ersdfesmld dfldnyeles ggrklakkdk 421 eierlkeaad evskgklsqr rnrerqekkk lekvtntlss lkf // LOCUS NP_012780 219 aa linear PLN 30-JUN-2025 DEFINITION Mrp8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012780 VERSION NP_012780.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179708.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 219) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09020. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..219 /product="Mrp8p" /calculated_mol_wt="24966" Region 1..219 /region_name="DUF3294" /note="Protein of unknown function (DUF3294); pfam07957" /db_xref="CDD:400351" CDS 1..219 /gene="MRP8" /locus_tag="YKL142W" /gene_synonym="YKL3" /coded_by="NM_001179708.1:1..660" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis" /db_xref="GeneID:853715" /db_xref="SGD:S000001625" ORIGIN 1 msneiellqk qvselqdlvk kqsliisktg ervlelqldk qkhdvtdfds kfsksiskks 61 gsatqfdatd fatnedlvel vkelqgelnf ieersirrlv nslkkddddv iaplpnadgd 121 ipaisdgvfp kslkefkdip dlklvrlakf yerlpptlke qedfenfleg kveafhinet 181 tdeeiskele kfskdeldda fndvarylgl slrrgteiw // LOCUS NP_012781 198 aa linear PLN 30-JUN-2025 DEFINITION succinate dehydrogenase cytochrome b subunit SDH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012781 VERSION NP_012781.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179707.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 198) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09021. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..198 /product="succinate dehydrogenase cytochrome b subunit SDH3" /calculated_mol_wt="21937" Region 12..116 /region_name="PLN00126" /note="succinate dehydrogenase, cytochrome b subunit family; Provisional" /db_xref="CDD:165695" Region 75..196 /region_name="SQR_TypeC_SdhC" /note="Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; cd03499" /db_xref="CDD:239579" Site order(75..78,83..85,87,90,97,163,166,168) /site_type="active" /note="Iron-sulfur protein interface [active]" /db_xref="CDD:239579" Site order(86,93..94,97) /site_type="other" /note="proximal quinone binding site [chemical binding]" /db_xref="CDD:239579" Site order(97,108,111,114..115,124,146,167,195) /site_type="other" /note="SdhD (CybS) interface [polypeptide binding]" /db_xref="CDD:239579" Site order(97,103..104,156..157) /site_type="other" /note="proximal heme binding site [chemical binding]" /db_xref="CDD:239579" CDS 1..198 /gene="SDH3" /locus_tag="YKL141W" /gene_synonym="CYB3; YKL4" /coded_by="NM_001179707.1:1..597" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0042721 TIM22 mitochondrial import inner membrane insertion complex [PMID:22152483]" /experiment="EXISTENCE:direct assay:GO:0045273 respiratory chain complex II (succinate dehydrogenase) [PMID:22152483|PMID:9822678]" /experiment="EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:18028869]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:22152483]" /experiment="EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:16232921]" /note="Subunit of succinate dehydrogenase and of TIM22 translocase; functions as cytochrome b subunit of succinate dehydrogenase, which couples oxidation of succinate to transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; also required for mitochondrial inner membrane protein import as part of the TIM22 complex; SDH3 has a paralog, SHH3, that arose from the whole genome duplication" /db_xref="GeneID:853716" /db_xref="SGD:S000001624" ORIGIN 1 msammvklgl nksalllkps afsraaalss srrllfntar tnflstsplk nvasemntka 61 aiaeeqilnk qrakrpisph ltiyqpqltw ylsslhrisl vlmglgfylf tilfgvsgll 121 glglttekvs nwyhqkfski tewsikgsfa ylfaihygga irhliwdtak eltlkgvyrt 181 gyaligftav lgtylltl // LOCUS NP_012782 548 aa linear PLN 30-JUN-2025 DEFINITION sterol esterase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012782 VERSION NP_012782.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179706.1 REFERENCE 1 (residues 1 to 548) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 548) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 548) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 548) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09022. Method: conceptual translation. FEATURES Location/Qualifiers source 1..548 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..548 /product="sterol esterase" /EC_number="3.1.1.13" /calculated_mol_wt="62848" Region 66..124 /region_name="Abhydro_lipase" /note="Partial alpha/beta-hydrolase lipase region; pfam04083" /db_xref="CDD:461162" Region 106..402 /region_name="Abhydrolase_1" /note="alpha/beta hydrolase fold; pfam00561" /db_xref="CDD:395444" CDS 1..548 /gene="TGL1" /locus_tag="YKL140W" /gene_synonym="YKL5" /coded_by="NM_001179706.1:1..1647" /experiment="EXISTENCE:direct assay:GO:0004771 sterol ester esterase activity [PMID:15713625]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:15713625|PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15713625]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:10515935]" /experiment="EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:15713625]" /note="Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes" /db_xref="GeneID:853717" /db_xref="SGD:S000001623" ORIGIN 1 myfpflgrls itdyiivvlv yiesiissvl klipqpminl fewlinfsts sddntieekl 61 rsaptihemc aifdisvedh lvrtednyil tlhrippisk nrfnnkvvyl hhgllmcsdv 121 wccnierhkn lpfvlhdlgy dvwmgnnrgn kystahlnkp pksnkfwdfs idefaffdip 181 nsiefildit kvdkvicigf sqgsaqmfaa fslseklnrk vshfiaiapa mtpkglhnri 241 vdtlaksspg fmylffgrki vlpsaviwqr tlhptlfnlc idiankilfn wksfnilprq 301 kiasyaklys ttsvksivhw fqilrsqkfq mfeesdnmln sltrpyqian fptrtnikip 361 illiyggids lvdidvmkkn lpfnsvfdvk vdnyehldli wgkdadtlvi akvlrfieff 421 npgnvsvktn qllpsaslve elpsttwktt hpthglsyrt hsadrsplsv qadeadevhn 481 adnsrflrrv fstsaidedn enehqddted qihkeqqrrl saylesskdl rqldansstt 541 aldalnke // LOCUS NP_012783 528 aa linear PLN 30-JUN-2025 DEFINITION cyclin-dependent serine/threonine protein kinase CTK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012783 VERSION NP_012783.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179705.1 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 528) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09023. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..528 /product="cyclin-dependent serine/threonine protein kinase CTK1" /EC_number="2.7.11.23" /calculated_mol_wt="60370" Region 183..469 /region_name="STKc_CDK9_like" /note="Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; cd07840" /db_xref="CDD:270832" Site order(189..192,197,210,212,229,243,260..263,266,268..269, 306,308,310..311,313,324,327,338,340..343,345,383..384) /site_type="active" /db_xref="CDD:270832" Site order(189..192,197,210,212,243,260..263,266,269,310..311, 313,324) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270832" Site order(221..223,225,228,232,235,245..248,250,256) /site_type="other" /note="CDK/cyclin interface [polypeptide binding]" /db_xref="CDD:270832" Site order(229,268,306,308,327,338,340..343,345,383..384) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270832" Site order(323..334,337..345) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270832" CDS 1..528 /gene="CTK1" /locus_tag="YKL139W" /coded_by="NM_001179705.1:1..1587" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:7565723]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9110987]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15520468]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15520468]" /experiment="EXISTENCE:direct assay:GO:0032786 positive regulation of DNA-templated transcription, elongation [PMID:9110987]" /experiment="EXISTENCE:direct assay:GO:0070692 CTDK-1 complex [PMID:7565723]" /experiment="EXISTENCE:genetic interaction:GO:0031124 mRNA 3'-end processing [PMID:12504017]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:25416238]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:12504017]" /experiment="EXISTENCE:mutant phenotype:GO:0045903 positive regulation of translational fidelity [PMID:17545469]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15520468]" /note="Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13" /db_xref="GeneID:853718" /db_xref="SGD:S000001622" ORIGIN 1 msynngntys ksysrnnkrp lfgkrspnpq slarppppkr irtdsgyqsn mdnisshrvn 61 sndqpghtks rgnnnlsryn dtsfqtssry qgsrynnnnt syenrpksik rdetkaefls 121 hlpkgpksve ksrynnssnt sndikngyha skyynhkgqe grsviakkvp vsvltqqrst 181 svylrimqvg egtygkvyka kntnteklva lkklrlqger egfpitsire ikllqsfdhp 241 nvstikeimv esqktvymif eyadndlsgl llnkevqish sqckhlfkql llgmeylhdn 301 kilhrdvkgs nilidnqgnl kitdfglark mnsradytnr vitlwyrppe lllgttnygt 361 evdmwgcgcl lvelfnktai fqgsneleqi esifkimgtp tinswptlyd mpwffmimpq 421 qttkyvnnfs ekfksvlpss kclqlainll cydqtkrfsa tealqsdyfk eepkpeplvl 481 dglvscheye vklarkqkrp nilstntnnk gngnsnnnnn nnnddddk // LOCUS NP_690844 69 aa linear PLN 30-JUN-2025 DEFINITION Hsk3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_690844 VERSION NP_690844.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184513.1 REFERENCE 1 (residues 1 to 69) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 69) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 69) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 69) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09024. Method: conceptual translation. FEATURES Location/Qualifiers source 1..69 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..69 /product="Hsk3p" /calculated_mol_wt="7957" Region 6..52 /region_name="DASH_Hsk3" /note="DASH complex subunit Hsk3 like; pfam08227" /db_xref="CDD:429874" CDS 1..69 /gene="HSK3" /locus_tag="YKL138C-A" /coded_by="NM_001184513.1:1..210" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15664196|PMID:15640796]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]" /experiment="EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479468|PMID:20479465]" /note="Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" /db_xref="GeneID:853719" /db_xref="SGD:S000028421" ORIGIN 1 mnankqrqyn qlahelrelq tnlqettkql dimskqcnen lvgqlgkvhg swligsyiyy 61 meqmlgktq // LOCUS NP_012784 131 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL60 MRPL31 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012784 VERSION NP_012784.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179704.1 REFERENCE 1 (residues 1 to 131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 131) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09025. Method: conceptual translation. FEATURES Location/Qualifiers source 1..131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..131 /product="mitochondrial 54S ribosomal protein mL60 MRPL31" /calculated_mol_wt="15389" Region 9..131 /region_name="L31" /note="Mitochondrial ribosomal protein L31; pfam09784" /db_xref="CDD:401656" CDS 1..131 /gene="MRPL31" /locus_tag="YKL138C" /gene_synonym="mL60" /coded_by="NM_001179704.1:1..396" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:853720" /db_xref="SGD:S000001621" ORIGIN 1 mfgpfkltsp vaggllwkip wrmsthqktr qrerlrnvdq vikqltlglh vqrcqdkglt 61 yqeameskkk ykprskslrl lnkpsvfpke nqmsskdkyw tfdkkavgyr kgihkvpkwt 121 kisirkapkf f // LOCUS NP_012785 111 aa linear PLN 30-JUN-2025 DEFINITION Cmc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012785 VERSION NP_012785.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179703.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 111) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09026. On Dec 19, 2005 this sequence version replaced NP_012785.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..111 /product="Cmc1p" /calculated_mol_wt="12876" Region 30..97 /region_name="Cmc1" /note="Cytochrome c oxidase biogenesis protein Cmc1 like; pfam08583" /db_xref="CDD:400756" CDS 1..111 /gene="CMC1" /locus_tag="YKL137W" /coded_by="NM_001179703.1:1..336" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:18443040]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:19703468]" /experiment="EXISTENCE:genetic interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:23198688]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:18443040|PMID:23198688]" /note="Copper-binding protein of the mitochondrial intermembrane space; evolutionarily conserved; may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif" /db_xref="GeneID:853721" /db_xref="SGD:S000001620" ORIGIN 1 meqnkdpqmi skhssrlpiw vlspreeqqa rknlktetyk kcanfvqama dcakangmkv 61 fptcdkqrde mkscllfyqt dekyldgerd kivlekinkl eklcqkqsst k // LOCUS NP_012787 726 aa linear PLN 30-JUN-2025 DEFINITION Apl2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012787 VERSION NP_012787.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179701.1 REFERENCE 1 (residues 1 to 726) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 726) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 726) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 726) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09027. Method: conceptual translation. FEATURES Location/Qualifiers source 1..726 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..726 /product="Apl2p" /calculated_mol_wt="81738" Region 6..726 /region_name="COG5096" /note="Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]" /db_xref="CDD:227427" Region 64..88 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(80..81,84,87..88,117..118,121,124..125,152..153,156, 159..160,163,191..192,195,198..199,234..235,238,241..242) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 100..127 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 134..164 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 173..199 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 214..242 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..726 /gene="APL2" /locus_tag="YKL135C" /coded_by="NM_001179701.1:1..2181" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030121 AP-1 adaptor complex [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:10564262]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:17003107]" /note="Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853723" /db_xref="SGD:S000001618" ORIGIN 1 mppldkrikk flkdsiriap kisgkgelse lrtglvsqyp qtrkdaikkt iqqmtlgkdv 61 sslfpdvlkn iatidveqkk lvylyvmnya ethpelcila vntfitdaqd pnplircmai 121 rtmsmirvdk ileyietplr rtlhddnayv rktavicvak lfqlnkdlcv elgvvedlvn 181 alddsnplvi anataaliei hnmdmdavdl ssliqshvsq fllalnecte wariiilgtl 241 seysakdsle aqdiidrvta hlqhvnpavv latikvivrn lpqieyssns limkrlssaf 301 vslmstppem qyvalkniri ilekypellt kelrifyvkf ndplyvklek idilvrlvdp 361 snlkqctlll telkeyamey epefvsraiq alsqlgikya qesfvskvld illellerqd 421 tikddccisl cdllrhcpgn dkmakqvcav fntwsnpevl lqsdiakcny vwllgqhpnn 481 fsdleskini fienfvqeea ltqmsllmti vrlhatltgs mlqsvlelat qqtheldvrd 541 mammywrcls mpnneslvnd lcqnklpmis ntlekfspev lekllmelgt issiyfkpds 601 nrrkgkkyvq nivkgkhiee lesmakneis skanddvlld fderddvtnt nagmlntltt 661 lgdlddlfdf gpsedatqin tndtkavqgl kelklggdsn gissggknnp dvsggnivsq 721 dlldlf // LOCUS NP_012788 772 aa linear PLN 30-JUN-2025 DEFINITION metalloendopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012788 VERSION NP_012788.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179700.2 REFERENCE 1 (residues 1 to 772) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 772) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 772) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 772) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 772) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 772) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 772) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09028. On Apr 26, 2011 this sequence version replaced NP_012788.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..772 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..772 /product="metalloendopeptidase" /EC_number="3.4.24.59" /calculated_mol_wt="88052" Region 76..763 /region_name="M3A_MIP" /note="Peptidase M3 mitochondrial intermediate peptidase (MIP); cd06457" /db_xref="CDD:341052" Site order(490..492,558..559,562,587,590,639,689..690,694..695, 697..698,701) /site_type="active" /db_xref="CDD:341052" CDS 1..772 /gene="OCT1" /locus_tag="YKL134C" /coded_by="NM_001179700.2:1..2319" /experiment="EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:8831696]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8035833]" /experiment="EXISTENCE:genetic interaction:GO:0006879 intracellular iron ion homeostasis [PMID:10332043]" /experiment="EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:8831696]" /experiment="EXISTENCE:mutant phenotype:GO:0006627 protein processing involved in protein targeting to mitochondrion [PMID:8035833]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:10332043]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:21525245]" /note="Mitochondrial intermediate peptidase; cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis" /db_xref="GeneID:853724" /db_xref="SGD:S000001617" ORIGIN 1 mlrtiilkag snasipspsr qnkllrffat agavsrtspg sikkifddns ywrningqda 61 nnskisqylf kknktglfkn pyltspdglr kfsqvslqqa qelldkmrnd fsesgkltyi 121 mnldrlsdtl crvidlcefi rsthpddafv raaqdcheqm fefmnvlntd vslcnilksv 181 lnnpevsskl saeelkvgki llddfeksgi ymnpdvrekf iqlsqeislv gqefinhtdy 241 pgsnsvkipc kdldnskvst fllkqlnkdv kgqnykvptf gyaayallks cenemvrkkl 301 wtalhscsdk qvkrlshlik lrailanlmh ktsyaeyqle gkmaknpkdv qdfiltlmnn 361 tiektanelk fiaelkakdl kkplttntde ilklvrpwdr dyytgkyfql npsnspnake 421 isyyftlgnv iqglsdlfqq iygirlepai tdegetwspd vrrlnvisee egiigiiycd 481 lferngktsn pahftvccsr qiypsetdfs tiqvgenpdg tyfqlpvisl vcnfspilia 541 skkslcflql sevetlfhem ghamhsmlgr thmqnisgtr catdfvelps ilmehfakdi 601 riltkigkhy gtgetiqadm lqrfmkstnf lqncetysqa kmamldqsfh dekiisdidn 661 fdvvenyqal errlkvlvdd qsnwcgrfgh lfgygatyys ylfdrtiask iwyalfeddp 721 ysrkngdkfk khllkwgglk dpwkciadvl ecpmlekggs damefiaqsh ks // LOCUS NP_012789 463 aa linear PLN 30-JUN-2025 DEFINITION Rci50p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012789 VERSION NP_012789.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179699.2 REFERENCE 1 (residues 1 to 463) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 463) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 463) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 463) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 463) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09029. On Apr 26, 2011 this sequence version replaced NP_012789.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..463 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..463 /product="Rci50p" /calculated_mol_wt="54357" Region 76..457 /region_name="Mgr3-like" /note="Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; cd24145" /db_xref="CDD:467945" CDS 1..463 /gene="RCI50" /locus_tag="YKL133C" /coded_by="NM_001179699.2:1..1392" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /note="Mitochondrial hypothetical protein; not required for growth of cells lacking the mitochondrial genome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; YKL133C has a paralog, MGR3, that arose from the whole genome duplication" /db_xref="GeneID:853725" /db_xref="SGD:S000001616" ORIGIN 1 mwkylhrsvk negtverltn lnlftnhrfk fystlkeqsf wripfkrrsk lqkwvlstgi 61 vsfiafniww vywphhtfpk pvakilrkgl hseikkegan yqksleyyle aleeckaenv 121 dllsdeytgi eikigemyek lhmyndatal ygdmlkkfyn elskttdkst krkffllkrd 181 lqilvrfnei nkdsetnatl limhlllaqr eflenspefk nvlskselln nqqldwknfk 241 glpfigkskp dyqmhlnskr kqelkikepe seqcvfmkel ltardlytry clnrsnlsga 301 lnskittlew mlladspldd illaqaelgs ifylnsekfe gslyaidnep ykksepleli 361 rsrlqenqns clqysadcyk siisfanenq ypkvamesem dqrilkalsl ahygigvinl 421 hkgrlraskk elkkairise mirfneliee aqrelkkvdg tpi // LOCUS NP_012790 430 aa linear PLN 30-JUN-2025 DEFINITION putative tetrahydrofolate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012790 VERSION NP_012790.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179698.1 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 430) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09030. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..430 /product="putative tetrahydrofolate synthase" /EC_number="6.3.2.17" /calculated_mol_wt="48012" Region 10..424 /region_name="PLN02881" /note="tetrahydrofolylpolyglutamate synthase; cl47075" /db_xref="CDD:481415" CDS 1..430 /gene="RMA1" /locus_tag="YKL132C" /coded_by="NM_001179698.1:1..1293" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="Putative dihydrofolate synthetase; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; RMA1 has a paralog, FOL3, that arose from the whole genome duplication" /db_xref="GeneID:853727" /db_xref="SGD:S000001615" ORIGIN 1 mddisgrqtl prinrllehv gnpqdslsil hiagtngket vskfltsilq hpgqqrqrvl 61 igryttssll nakeedisin neaislieys riekeliead sslklqcnnl elltsvalvy 121 fakkncqwci ietglagkqd pgsiiagqsr vccaitnvgi sdeaflckfl sqitesstnk 181 aiflldgsnd efvrntitkr chdvgcplei tdpslrdynv htdtwgtlev rlpyseeeyq 241 ifnlrvaiav ldflskekkv ciskdqlsqg lisvdwprsl hrldycyest sgkkiallld 301 nannakaarn lachlrttyg dtpltfviai ttgkkvspll dplirpqdyv ivtrfgsvvg 361 mpwiqslepv nllafiknry trnvnmqpdl qsvwtflets glktivpviv cgslyickel 421 lrlhnchlpv // LOCUS NP_012792 246 aa linear PLN 30-JUN-2025 DEFINITION She2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012792 VERSION NP_012792.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179696.1 REFERENCE 1 (residues 1 to 246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 246) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09031. Method: conceptual translation. FEATURES Location/Qualifiers source 1..246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..246 /product="She2p" /calculated_mol_wt="28120" Region 18..222 /region_name="She2p" /note="RNA binding protein She2p; pfam11435" /db_xref="CDD:402856" CDS 1..246 /gene="SHE2" /locus_tag="YKL130C" /coded_by="NM_001179696.1:1..741" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11101531]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8625407]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11032818]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:24056370]" /experiment="EXISTENCE:direct assay:GO:0008298 intracellular mRNA localization [PMID:24056370|PMID:11032818]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:28092367]" /experiment="EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:8625407]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:28092367]" /note="RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; binds to ER-derived membranes and targets mRNAs to cortical ER" /db_xref="GeneID:853728" /db_xref="SGD:S000001613" ORIGIN 1 mskdkdikvt pgtcelveqi lallsrylss yihvlnkfis hlrrvatlrf erttlikfvk 61 klrfyndcvl synasefine gkneldpead sfdkvilpia smfvkcvetf dllnyyltqs 121 lqkeilsktl nedltltaes ilaiddtynh fvkfsqwmie slrigsnlld levvqfaikc 181 adedgtnige tdniflqeil pvnseeefqt lsaawhsild gklsaldeef dvvatkwhdk 241 fgklkn // LOCUS NP_012793 1272 aa linear PLN 30-JUN-2025 DEFINITION myosin 3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012793 VERSION NP_012793.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179695.2 REFERENCE 1 (residues 1 to 1272) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1272) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1272) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1272) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09032. On Apr 26, 2011 this sequence version replaced NP_012793.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1272 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1272 /product="myosin 3" /calculated_mol_wt="142321" Region 1..1258 /region_name="COG5022" /note="Myosin heavy chain [General function prediction only]" /db_xref="CDD:227355" CDS 1..1272 /gene="MYO3" /locus_tag="YKL129C" /coded_by="NM_001179695.2:1..3819" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:11604421]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:18177206]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]" /note="One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication" /db_xref="GeneID:853729" /db_xref="SGD:S000001612" ORIGIN 1 mavikkgarr kdvkepkkrs akikkatfda nkkkevgisd ltllskisde sinenlkkrf 61 kngiiytyig hvlisvnpfr dlgiytnavl esykgknrle vpphvfaiae smyynlksyn 121 enqcviisge sgagkteaak rimqyiaaas nshsesigki kdmvlatnpl lesfgcaktl 181 rnnnssrhgk yleikfnsqf epcagnitny llekqrvvgq iknernfhif yqftkgasdt 241 ykqmfgvqmp eqyiytaaag cttadtiddv kdyegtleam rtiglvqeeq dqifrmlaai 301 lwignisfie neegnaqvgd tsvtdfvayl lqvdasllvk clverimqts hgmkrgsvyh 361 vplnpvqata vrdalakaiy nnlfdwivdr vnvslqafpg adksigildi ygfeifehns 421 feqicinyvn eklqqifiql tlkaeqetye rekikwtpik yfdnkvvcdl ieaknppgil 481 aamndsiata hadsnaadqa faqrlnlfns npyfelrank fvikhyagdv tydingitdk 541 nkdqlqkdli eligtttntf lstifpddvd kdskrrppta gdkiiksane lvetlskaep 601 syirtikpnq tkspndyddh qvlhqvkylg lqenvrirra gfayrqtfek fverfyllsp 661 dcsyagdytw dgdtleavkl ilrdamipek efqlgvtsvf iktpeslfal edmrdkywyn 721 maariqrawr rflqrridaa ikiqrtirek kggnkyvklr dygtkllagk kerrsmsllg 781 yrafmgdyls cnesktkgsy irrqvgikdk vvfsikgecl hskfgrsaqr lkkvfiltkk 841 tfyiigqtre qnamkytqdy kidvgkikqv sltnlqddwm gvilvnstqs dplintpfkt 901 elmtrlkkln ekimikvgpt ieyhkqpnkl htvrskisds apkygdiyks stiyvrrghp 961 ansksnkkpk npgglsgkpi kskkskhkst hkhthshrsh rdaakkqplp sqkpvnplsl 1021 aataaqaayn pkpdktvpik ssaipaakvs skhsskpssk ekvavkkass shksssakqn 1081 qvsmppskgv eknkeplket tatatanipi ppppppmgqp kdpkfeaayd fpgsgsssel 1141 plkkgdivfi srdepsgwsl aklldgskeg wvptaymtpy kdtrntvpva atgavndvtn 1201 qkssqidnti ssaqegvqfg satvgptsdn qsnpvgtfsd glasalaara nkmraesadd 1261 ddnddgdddd dw // LOCUS NP_012794 295 aa linear PLN 30-JUN-2025 DEFINITION putative phosphomutase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012794 VERSION NP_012794.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179694.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 295) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09033. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..295 /product="putative phosphomutase" /calculated_mol_wt="33645" Region 56..>170 /region_name="HP_PGM_like" /note="Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; cd07067" /db_xref="CDD:132718" CDS 1..295 /gene="PMU1" /locus_tag="YKL128C" /coded_by="NM_001179694.1:1..888" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /note="Putative phosphomutase; contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant; localizes to cytosol an peroxisomes" /db_xref="GeneID:853730" /db_xref="SGD:S000001611" ORIGIN 1 mslravpgyf aaypsegfqg ldstkydhle linhknwkel yhaiprntkn rhykllilar 61 hgqgyhnaai lrygmekwda ywsllsgdeh gewldskltp lgkdqvrrtg snvllpmakq 121 lgmlphvffs spmrrcletf ieswtpvlae tqelpagtki striieglre tlgshtcdkr 181 vahsmavdey qdfstesght vhwqyvpdyp eddelwlpdh retcaemdkr tlnglfelfn 241 qlsseekfis ltchsgviqs vlrnlqhppi ynldtgkvva vvvevpvnta drgrl // LOCUS NP_012795 570 aa linear PLN 30-JUN-2025 DEFINITION phosphoglucomutase PGM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012795 VERSION NP_012795.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179693.1 REFERENCE 1 (residues 1 to 570) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 570) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 570) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 570) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09034. Method: conceptual translation. FEATURES Location/Qualifiers source 1..570 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..570 /product="phosphoglucomutase PGM1" /EC_number="5.4.2.2" /calculated_mol_wt="62981" Region 8..570 /region_name="phosphohexomutase" /note="The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; cl38939" /db_xref="CDD:476822" Site order(19,21,24,120..122,133,291,293,295..296,339,360..362, 379,381,383,511,513..515,523) /site_type="active" /db_xref="CDD:100086" Site order(21,120,296,339,360,362,379,381,383,511,513..515,523) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:100086" Site order(120,291,293,295) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:100086" CDS 1..570 /gene="PGM1" /locus_tag="YKL127W" /coded_by="NM_001179693.1:1..1713" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8385141]" /experiment="EXISTENCE:genetic interaction:GO:0004614 phosphoglucomutase activity [PMID:8119301]" /experiment="EXISTENCE:genetic interaction:GO:0005978 glycogen biosynthetic process [PMID:9252577]" /experiment="EXISTENCE:genetic interaction:GO:0005992 trehalose biosynthetic process [PMID:9252577]" /experiment="EXISTENCE:genetic interaction:GO:0006011 UDP-alpha-D-glucose metabolic process [PMID:9252577]" /experiment="EXISTENCE:genetic interaction:GO:0019255 glucose 1-phosphate metabolic process [PMID:8119301]" /experiment="EXISTENCE:genetic interaction:GO:0019388 galactose catabolic process [PMID:8119301]" /experiment="EXISTENCE:genetic interaction:GO:0051156 glucose 6-phosphate metabolic process [PMID:8119301]" /note="Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; PGM1 has a paralog, PGM2, that arose from the whole genome duplication" /db_xref="GeneID:853732" /db_xref="SGD:S000001610" ORIGIN 1 msllidsvpt vaykdqkpgt sglrkktkvf mdephytenf iqatmqsipn gsegttlvvg 61 gdgrfyndvi mnkiaavgaa ngvrklvigq ggllstpaas hiirtyeekc tgggiiltas 121 hnpggpendl gikynlpngg papesvtnai weaskklthy kiiknfpkln lnklgknqky 181 gpllvdiidp akayvqflke ifdfdliksf lakqrkdkgw kllfdslngi tgpygkaifv 241 defglpaeev lqnwhplpdf gglhpdpnlt yartlvdrvd rekiafgaas dgdgdrnmiy 301 gygpafvspg dsvaiiaeya peipyfakqg iyglarsfpt ssaidrvaak kglrcyevpt 361 gwkffcalfd akklsicgee sfgtgsnhir ekdglwaiia wlnilaiyhr rnpekeasik 421 tiqdefwney grtfftrydy ehieceqaek vvallsefvs rpnvcgshfp adesltvidc 481 gdfsyrdldg sisenqglfv kfsngtkfvl rlsgtgssga tirlyvekyt dkkenygqta 541 dvflkpvins ivkflrfkei lgtdeptvrt // LOCUS NP_012796 680 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase YPK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012796 VERSION NP_012796.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179692.1 REFERENCE 1 (residues 1 to 680) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 680) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 680) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 680) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 680) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 680) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 680) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09035. Method: conceptual translation. FEATURES Location/Qualifiers source 1..680 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..680 /product="serine/threonine protein kinase YPK1" /EC_number="2.7.11.1" /calculated_mol_wt="76349" Region 116..342 /region_name="YPK1_N_like" /note="Fungal protein kinase domain similar to the N-terminus of YPK1; cd11651" /db_xref="CDD:212165" Region 352..663 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(353..356,359,361,374,376,408,424..427,470,474..475, 477,487..488) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..680 /gene="YPK1" /locus_tag="YKL126W" /gene_synonym="SLI2" /coded_by="NM_001179692.1:1..2043" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:22080611|PMID:19966303|PMID:29352143]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12221112|PMID:10825204]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10825204]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10825204]" /experiment="EXISTENCE:genetic interaction:GO:0006650 glycerophospholipid metabolic process [PMID:25258318]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:12221112]" /experiment="EXISTENCE:genetic interaction:GO:0070941 eisosome assembly [PMID:18296441]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:10825204|PMID:26274562]" /experiment="EXISTENCE:mutant phenotype:GO:0006650 glycerophospholipid metabolic process [PMID:25258318]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:12221112]" /experiment="EXISTENCE:mutant phenotype:GO:0061093 negative regulation of phospholipid translocation [PMID:19966303]" /experiment="EXISTENCE:mutant phenotype:GO:0071311 cellular response to acetate [PMID:27671892]" /experiment="EXISTENCE:mutant phenotype:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:22080611]" /note="S/T protein kinase; required for PM lipid and protein homeostasis; involved in sphingolipid-mediated and cell integrity signaling pathways and endocytosis; phosphorylates and downregulates Fpk1p; phosphorylates and inactivates Orm1p/2p when sphingolipid synthesis is compromised; role in TORC1/2-dependent Rps6a/b phosphorylation; phosphorylated and activated by TORC2 and by Pkh1/2p in the presence of phytosphingosine; human homolog SGK1 complements the null and inviability of a ypk1 ypk2 mutant" /db_xref="GeneID:853733" /db_xref="SGD:S000001609" ORIGIN 1 myswkskfkf gkskeekeak hsgffhsskk eeqqnnqata gehdasitrs sldrkgtinp 61 snssvvpvrv sydassstst vrdsnggnse ntnssqnlde tanigstgtp ndatsssgmm 121 tikvyngddf ilpfpitsse qilnkllasg vppphkeisk evdaliaqls rvqiknqgpa 181 dedlissesa akfipstiml pgsstlnpll yftiefdntv atieaeygti akpgfnkist 241 fdvtrklpyl kidvfarips illpsktwqq emglqdeklq tifdkinsnq dihldsfhlp 301 inlsfdsaas irlynhhwit ldnglgkini sidykpsrnk plsiddfdll kvigkgsfgk 361 vmqvrkkdtq kvyalkairk syivsksevt htlaertvla rvdcpfivpl kfsfqspekl 421 yfvlafingg elfyhlqkeg rfdlsrarfy taellcaldn lhkldvvyrd lkpenilldy 481 qghialcdfg lcklnmkddd ktdtfcgtpe ylapelllgl gytkavdwwt lgvllyemlt 541 glppyydedv pkmykkilqe plvfpdgfdr dakdlligll srdptrrlgy ngadeirnhp 601 ffsqlswkrl lmkgyippyk pavsnsmdts nfdeeftrek pidsvvdeyl sesvqkqfgg 661 wtyvgneqlg ssmvqgrsir // LOCUS NP_012797 627 aa linear PLN 30-JUN-2025 DEFINITION rDNA-binding RNA polymerase I transcriptional factor [Saccharomyces cerevisiae S288C]. ACCESSION NP_012797 VERSION NP_012797.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179691.1 REFERENCE 1 (residues 1 to 627) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 627) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 627) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 627) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09036. Method: conceptual translation. FEATURES Location/Qualifiers source 1..627 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..627 /product="rDNA-binding RNA polymerase I transcriptional factor" /calculated_mol_wt="72257" Region 47..618 /region_name="RRN3" /note="RNA polymerase I specific transcription initiation factor RRN3; pfam05327" /db_xref="CDD:461623" CDS 1..627 /gene="RRN3" /locus_tag="YKL125W" /coded_by="NM_001179691.1:1..1884" /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:23393135]" /experiment="EXISTENCE:direct assay:GO:0001042 RNA polymerase I core binding [PMID:11032814]" /experiment="EXISTENCE:direct assay:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:11032814]" /experiment="EXISTENCE:direct assay:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:11032814]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19416370]" /experiment="EXISTENCE:genetic interaction:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:11032814]" /experiment="EXISTENCE:mutant phenotype:GO:0006361 transcription initiation at RNA polymerase I promoter [PMID:8670901]" /experiment="EXISTENCE:physical interaction:GO:0001042 RNA polymerase I core binding [PMID:11032814]" /experiment="EXISTENCE:physical interaction:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:11032814]" /experiment="EXISTENCE:physical interaction:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:11032814]" /note="Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylation of serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo" /db_xref="GeneID:853734" /db_xref="SGD:S000001608" ORIGIN 1 mmafentskr ppqdfvapid qkkrkvqfsd stglvtlqpe eikdevfsaa mysrfvksal 61 ddldkndstq igiianqval psknperind knlnilldil ssninriess rgtfliqsii 121 nfekwwelpp htlskyiyfi kilcssipkw wqdvsmilvs cfilpikqtv chhdmlkyfl 181 rmipssmgfi dtylakffpn kndtrrklvn ytsnllklrg ycselgfqiw slliekiisi 241 dvelqnelde ldddvddddl eevdledddd ldddsgdddd encgnsneel rsgaadgsqs 301 dsedmdiieg mdgteeynve ltqgikelst kldsiltlvs thveeqvtpe slesgegvgv 361 fntlttlfkt hvlptyytrs iqyimfhvsq qqlelmdsfl vtlidisfav neaaekkiks 421 lqylgsyiar akklsrtqii fvasyltswl nryviereee vdqrggmerf khfyaafqal 481 cyifcfrhni frdtdgnwec eldkffqrmv iskfnplkfc nenvmlmfar iaqqesvayc 541 fsiiennnne rlrgiigkad sdkkensaqa nttssswsla trqqfidlqs yfpydplflk 601 nykilmkeyy iewseasgey esdgsdd // LOCUS NP_012798 579 aa linear PLN 30-JUN-2025 DEFINITION Ssh4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012798 VERSION NP_012798.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179690.1 REFERENCE 1 (residues 1 to 579) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 579) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 579) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 579) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09037. Method: conceptual translation. FEATURES Location/Qualifiers source 1..579 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..579 /product="Ssh4p" /calculated_mol_wt="64930" Region 199..341 /region_name="SPRY" /note="SPRY domain; cl02614" /db_xref="CDD:470632" CDS 1..579 /gene="SSH4" /locus_tag="YKL124W" /gene_synonym="MLF4" /coded_by="NM_001179690.1:1..1740" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:17287526]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17287526]" /experiment="EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:30361468|PMID:18367543]" /experiment="EXISTENCE:mutant phenotype:GO:1990756 ubiquitin-like ligase-substrate adaptor activity [PMID:30361468]" /note="Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases" /db_xref="GeneID:853735" /db_xref="SGD:S000001607" ORIGIN 1 myvtfneald ssfgnlespn hdfkvgdpnm vptppmdsds aaislaflis lsitfailml 61 ilvviaayvt fcgddeseyd eenalgtrts gtlhslfgkk hsgilldssf aspggfddei 121 vlqereleel pkmsayevel yirakefqmm sppmvkdfgt yldsddqqfi kdrgiqsyfl 181 lpsindnide ygnflpsfiv qdkldiqfsk fnkssstvmn yplphnrkda vyfevkifrh 241 iqksnsifsi glttvpypyf rvpgmakysi ayestgklri nnpftastll pkleegdtvg 301 fgyryktgti fithngkklm dvtqnigidl figigafnaa ytrtytrdgl ledpdnvsfr 361 ealsegkdie vakdlqrvhd phdesdemts develhvnlg qvgfvfiean vkkyafgsvy 421 gqigippayn gteikkdtil qkgeelppry adtdnffgsm kvkegsssri taqtskplws 481 vgtyerissn fdrennvyhd sletddnntd nnvnnndena gcnensplle ddgnkrpens 541 ntprevsdga inknprnkst kkrqrnrgks skkknrsrk // LOCUS NP_012800 167 aa linear PLN 30-JUN-2025 DEFINITION signal recognition particle subunit SRP21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012800 VERSION NP_012800.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179688.1 REFERENCE 1 (residues 1 to 167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 167) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09038. Method: conceptual translation. FEATURES Location/Qualifiers source 1..167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..167 /product="signal recognition particle subunit SRP21" /calculated_mol_wt="18294" Region 3..78 /region_name="SRP9-21" /note="Signal recognition particle 9 kDa protein (SRP9); pfam05486" /db_xref="CDD:428490" CDS 1..167 /gene="SRP21" /locus_tag="YKL122C" /coded_by="NM_001179688.1:1..504" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]" /experiment="EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]" /note="Subunit of the signal recognition particle (SRP); SRP functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm" /db_xref="GeneID:853737" /db_xref="SGD:S000001605" ORIGIN 1 msvkpidnyi tnsvrlfevn psqtlfsisy kpptqktdtk vsfrthnshl slnykfttnk 61 skdvsrllsa lgprgvsitp gkiekiaqsk kknnkikess kkikgksiqd ivglatlivn 121 tdveksdpaa kktatepkqk anavqnnngn saaskkkknk nkgkkkr // LOCUS NP_012801 852 aa linear PLN 30-JUN-2025 DEFINITION Dgr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012801 VERSION NP_012801.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179687.1 REFERENCE 1 (residues 1 to 852) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 852) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 852) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 852) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 852) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09039. Method: conceptual translation. FEATURES Location/Qualifiers source 1..852 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..852 /product="Dgr2p" /calculated_mol_wt="95891" Region 173..506 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 176..238 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Site order(190,194,200..201,213..214,235,240,246..247,278..279, 296,300,306..307,319,337,342,348..349,361,380,384,390..391, 403..404,448,453,459..460,472..473,495,499,505..506) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 244..278 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 283..317 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 324..360 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 365..414 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 422..476 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..852 /gene="DGR2" /locus_tag="YKL121W" /coded_by="NM_001179687.1:1..2559" /note="hypothetical protein; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds; DGR2 has a paralog, YMR102C, that arose from the whole genome duplication" /db_xref="GeneID:853738" /db_xref="SGD:S000001604" ORIGIN 1 mfksktstls ydetpnsneg drnatpvnpk eksqtkhlni pgdrsrhssi adskrsssry 61 dggysadiip aqlrfidnid ygtrlrktlh rnsvvsngyn klsendrwyf dlfdrkyfen 121 yleeptyiki fkkkegleqf drmflaqelk ipdvykstty qgepavanse lfknsiccct 181 fshdgkymvi gckdgslhlw kvinspvkrs emgrseksvs asranslkiq rhlasisshn 241 gsissndlkp sdqfegpskq lhlyapvfys dvfrvfmeha ldildanwsk ngflitasmd 301 ktaklwhper kyslktfvhp dfvtsaiffp nddrfiitgc ldhrcrlwsi ldnevsyafd 361 ckdlitsltl sppggeytii gtfngyiyvl lthglkfvss fhvsdkstqg ttknsfhpss 421 eygkvqhgpr itglqcffsk vdknlrlivt tndskiqifd lnekkplelf kgfqsgssrh 481 rgqflmmkne pvvftgsddh wfytwkmqsf nlsaemncta phrkkrlsgs mslkgllriv 541 snkstndecl tetsnqsssh tftnssknvl qtqtvgsqai knnhyisfha hnspvtcasi 601 apdvaiknls lsndlifelt sqyfkemgqn ysesketcdn kpnhpvtetg gfssnlsnvv 661 nnvgtilitt dsqglirvfr tdilpeirkk iiekfheynl fhleaagkin nhnndsilen 721 rmderssted nefsttppsn thnsrpshdf celhpnnspv isgmpsrasa ifknsifnks 781 ngsfislksr sestsstvfg phdiprvstt ypklkcdvcn gsnfecaskn piaggdsgft 841 cadcgtilnn fr // LOCUS NP_012802 324 aa linear PLN 30-JUN-2025 DEFINITION Oac1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012802 VERSION NP_012802.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179686.1 REFERENCE 1 (residues 1 to 324) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 324) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 324) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 324) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09040. Method: conceptual translation. FEATURES Location/Qualifiers source 1..324 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..324 /product="Oac1p" /calculated_mol_wt="35022" Region 26..294 /region_name="PTZ00169" /note="ADP/ATP transporter on adenylate translocase; Provisional" /db_xref="CDD:240302" CDS 1..324 /gene="OAC1" /locus_tag="YKL120W" /coded_by="NM_001179686.1:1..975" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10428783]" /experiment="EXISTENCE:direct assay:GO:0015116 sulfate transmembrane transporter activity [PMID:10428783]" /experiment="EXISTENCE:direct assay:GO:0015131 oxaloacetate transmembrane transporter activity [PMID:10428783]" /experiment="EXISTENCE:direct assay:GO:0015729 oxaloacetate transport [PMID:10428783]" /experiment="EXISTENCE:direct assay:GO:0034658 isopropylmalate transmembrane transporter activity [PMID:18682385]" /experiment="EXISTENCE:direct assay:GO:0034659 isopropylmalate transport [PMID:18682385]" /experiment="EXISTENCE:direct assay:GO:1901239 malonate(1-) transmembrane transporter activity [PMID:10428783]" /experiment="EXISTENCE:direct assay:GO:1902358 sulfate transmembrane transport [PMID:10428783]" /note="Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family" /db_xref="GeneID:853739" /db_xref="SGD:S000001603" ORIGIN 1 mssdnskqdk qiektaaqki skfgsfvagg laaciavtvt npielikirm qlqgemsasa 61 akvyknpiqg mavifknegi kglqkglnaa yiyqiglngs rlgfyepirs slnqlffpdq 121 ephkvqsvgv nvfsgaasgi igavigsplf lvktrlqsys efikigeqth ytgvwnglvt 181 ifktegvkgl frgidaailr tgagssvqlp iyntaknilv kndlmkdgpa lhltastisg 241 lgvavvmnpw dviltriynq kgdlykgpid clvktvrieg vtalykgfaa qvfriaphti 301 mcltfmeqtm klvysiesrv lghn // LOCUS NP_012803 215 aa linear PLN 30-JUN-2025 DEFINITION Vph2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012803 VERSION NP_012803.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179685.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 215) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09041. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..215 /product="Vph2p" /calculated_mol_wt="25156" Region 64..196 /region_name="Vma12" /note="Endoplasmic reticulum-based factor for assembly of V-ATPase; pfam11712" /db_xref="CDD:463329" CDS 1..215 /gene="VPH2" /locus_tag="YKL119C" /gene_synonym="CLS10; VMA12" /coded_by="NM_001179685.1:1..648" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9325326]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:1628805]" /experiment="EXISTENCE:mutant phenotype:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:9325326]" /experiment="EXISTENCE:physical interaction:GO:1990871 Vma12-Vma22 assembly complex [PMID:9660861]" /note="Integral membrane protein required for V-ATPase function; not an actual component of the vacuolar H+-ATPase (V-ATPase) complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER); involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner" /db_xref="GeneID:853741" /db_xref="SGD:S000001602" ORIGIN 1 mfeiklndri teflrkfkns aksnegided idlflkrhai pmqsllfyvk eyrkdsdlqc 61 sikellkple fefkpkavrg lhysedfkkk leflkyqeqe leyqsmvkrs ksvfslqedd 121 eltpsqinkq ikeqvttvfn vlvsvisvvv aiwywtgsst nfpvhvrlll clffgilvlv 181 advvvynsyl kkleeakvke ktkvekkkvl skitl // LOCUS NP_012805 216 aa linear PLN 30-JUN-2025 DEFINITION Hsp90 cochaperone SBA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012805 VERSION NP_012805.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179683.1 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 216) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09042. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..216 /product="Hsp90 cochaperone SBA1" /calculated_mol_wt="23951" Region 8..129 /region_name="p23_hB-ind1_like" /note="p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF)...; cd06465" /db_xref="CDD:107222" Site order(14,33..34,83,89,105,116,118..119,121..122,124) /site_type="active" /note="Hsp90 binding site [active]" /db_xref="CDD:107222" CDS 1..216 /gene="SBA1" /locus_tag="YKL117W" /gene_synonym="CST18" /coded_by="NM_001179683.1:1..651" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10207098]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10207098]" /experiment="EXISTENCE:direct assay:GO:0032212 positive regulation of telomere maintenance via telomerase [PMID:17389357]" /experiment="EXISTENCE:direct assay:GO:0043392 negative regulation of DNA binding [PMID:23022381]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9632755]" /experiment="EXISTENCE:mutant phenotype:GO:0032212 positive regulation of telomere maintenance via telomerase [PMID:17389357]" /experiment="EXISTENCE:mutant phenotype:GO:0051087 protein-folding chaperone binding [PMID:9632755]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:9632755]" /experiment="EXISTENCE:physical interaction:GO:0051087 protein-folding chaperone binding [PMID:9632755]" /note="Co-chaperone that binds and regulates Hsp90 family chaperones; plays a role in determining prion variants; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins, and like p23 can regulate telomerase activity; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853743" /db_xref="SGD:S000001600" ORIGIN 1 msdkvinpqv awaqrssttd pernyvlitv siadcdapel tikpsyielk aqskphvgde 61 nvhhyqlhid lykeiipekt mhkvangqhy flklykkdle seywprltke kvkypyiktd 121 fdkwvdedeq deveaegnda aqgmdfsqmm ggaggaggag gmdfsqmmgg aggagspdma 181 qlqqllaqsg gnldmgdfke ndeedeeeei epevka // LOCUS NP_012806 518 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase PRR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012806 VERSION NP_012806.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179682.1 REFERENCE 1 (residues 1 to 518) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 518) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 518) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 518) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09043. Method: conceptual translation. FEATURES Location/Qualifiers source 1..518 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..518 /product="serine/threonine protein kinase PRR1" /EC_number="2.7.11.1" /calculated_mol_wt="58825" Region 192..508 /region_name="S_TKc" /note="Serine/Threonine protein kinases, catalytic domain; smart00220" /db_xref="CDD:214567" Site order(198..201,204,206,223,225,272,307..310,354,358..359, 361,387..388) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..518 /gene="PRR1" /locus_tag="YKL116C" /coded_by="NM_001179682.1:1..1557" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11337509]" /experiment="EXISTENCE:genetic interaction:GO:0031138 negative regulation of conjugation with cellular fusion [PMID:11337509]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11337509]" /experiment="EXISTENCE:mutant phenotype:GO:0031138 negative regulation of conjugation with cellular fusion [PMID:11337509]" /note="Serine/threonine protein kinase; inhibits pheromone induced signaling downstream of MAPK, possibly at the level of the Ste12p transcription factor" /db_xref="GeneID:853744" /db_xref="SGD:S000001599" ORIGIN 1 mdeyssiysq pktprlkqeg fpdsigdqhe kalidengee dkkmastegt tgdsrstplt 61 vsiptfenvq alptpmtytp lspgnlsmsp idqsslnipk rrsharlldd mlsvtqpnqr 121 vvseliapan lspqrvvslp tvteealvnd svdsdnytke pyfpesssst ekcdddifqg 181 flldhwdrpl lwkkvrpigs gnfstvllye lmdqsnpklk qvavkrlkyp eelsnveqin 241 tslryketls rlensltrel qvlkslnhpc ivkllginnp ifvtskkplc dliiktpral 301 ppcdmimsyc pagdllaavm arngrleawl iqriftevvl avkylhensi ihrdlkleni 361 llkysfddin sfrdspiyck qnfieladfg lckkiennem ctarcgsedy vspeilmgvp 421 ydghlsdtwa lgvilyslfe drlpfdpppn asarqrsrat shriarfdwr wyrlsdyktn 481 vgkqiventl trknqrwsin eiyespfvkt iadtlsfs // LOCUS NP_012808 367 aa linear PLN 30-JUN-2025 DEFINITION DNA-(apurinic or apyrimidinic site) lyase APN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012808 VERSION NP_012808.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179680.1 REFERENCE 1 (residues 1 to 367) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 367) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 367) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 367) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09044. Method: conceptual translation. FEATURES Location/Qualifiers source 1..367 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..367 /product="DNA-(apurinic or apyrimidinic site) lyase APN1" /calculated_mol_wt="41308" Region 15..290 /region_name="nfo" /note="apurinic endonuclease (APN1); TIGR00587" /db_xref="CDD:273156" Site order(20,45,86,274,283) /site_type="active" /note="AP (apurinic/apyrimidinic) site pocket [active]" /db_xref="CDD:237986" Site order(48..52,86..87,89,92) /site_type="other" /note="DNA interaction" /db_xref="CDD:237986" Site order(83,123,158,192,195,229,242,244,274) /site_type="metal-binding" /note="Metal-binding active site" /db_xref="CDD:237986" CDS 1..367 /gene="APN1" /locus_tag="YKL114C" /coded_by="NM_001179680.1:1..1104" /experiment="EXISTENCE:direct assay:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:12767225]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7690756]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11238901]" /experiment="EXISTENCE:direct assay:GO:0006284 base-excision repair [PMID:9295360]" /experiment="EXISTENCE:direct assay:GO:0008081 phosphoric diester hydrolase activity [PMID:3056935]" /experiment="EXISTENCE:direct assay:GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity [PMID:16024777]" /experiment="EXISTENCE:direct assay:GO:0017005 3'-tyrosyl-DNA phosphodiesterase activity [PMID:12397185]" /experiment="EXISTENCE:mutant phenotype:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:1693433]" /note="Major apurinic/apyrimidinic endonuclease; 3'-repair diesterase; involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine; genetically interacts with NTG1 to maintain mitochondrial genome integrity" /db_xref="GeneID:853746" /db_xref="SGD:S000001597" ORIGIN 1 mpstpsfvrs avskykfgah msgaggisns vtnafntgcn sfamflkspr kwvspqytqe 61 eidkfkknca tynynpltdv lphgqyfinl anpdrekaek syesfmddln rceqlgigly 121 nlhpgstlkg dhqlqlkqla sylnkaiket kfvkivlenm agtgnlvgss lvdlkevigm 181 iedksrigvc idtchtfaag ydisttetfn nfwkefndvi gfkylsavhl ndskaplgan 241 rdlherlgqg ylgidvfrmi ahseylqgip ivletpyend egygneiklm ewlesksese 301 lledkeykek ndtlqklgak srkeqldkfe vkqkkraggt krkkataeps dndilsqmtk 361 krktkke // LOCUS NP_012809 382 aa linear PLN 30-JUN-2025 DEFINITION multifunctional nuclease RAD27 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012809 VERSION NP_012809.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179679.1 REFERENCE 1 (residues 1 to 382) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 382) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 382) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 382) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09045. Method: conceptual translation. FEATURES Location/Qualifiers source 1..382 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..382 /product="multifunctional nuclease RAD27" /calculated_mol_wt="43148" Region 1..364 /region_name="PIN_SF" /note="PIN (PilT N terminus) domain: Superfamily; cl28905" /db_xref="CDD:475124" Site order(7,34,36..37,40,42,44..48,54..55,62,66,70..71,74,87, 94,101,126,131,156,158,177,179,190,193,317..320,323) /site_type="active" /db_xref="CDD:350215" Site order(28..30,81,165..167,206,208..209,300..301,303) /site_type="other" /note="FEN1-PCNA interface [polypeptide binding]" /db_xref="CDD:350215" Site order(45..48,62,66,70..71,74,193,317,319..320,323,326,330) /site_type="other" /note="3' dsDNA binding site [nucleotide binding]" /db_xref="CDD:350215" Site order(93..98,130..133) /site_type="other" /note="helical arch" /db_xref="CDD:350215" CDS 1..382 /gene="RAD27" /locus_tag="YKL113C" /gene_synonym="ERC11; FEN1; RTH1" /coded_by="NM_001179679.1:1..1149" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:36672839|PMID:19699691|PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19699691]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15342630]" /experiment="EXISTENCE:direct assay:GO:0008409 5'-3' exonuclease activity [PMID:9166764]" /experiment="EXISTENCE:direct assay:GO:0017108 5'-flap endonuclease activity [PMID:36672839|PMID:11825897]" /experiment="EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:36672839|PMID:16837458]" /experiment="EXISTENCE:genetic interaction:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:16079237]" /experiment="EXISTENCE:mutant phenotype:GO:0007534 gene conversion at mating-type locus [PMID:10025407]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:16079237]" /note="5' to 3' exonuclease, 5' flap endonuclease; required for Okazaki fragment processing and maturation, for long-patch base-excision repair and large loop repair (LLR), ribonucleotide excision repair; cleaves off RNA flap in a RNA:DNA hybrid intermediate during processing of DNA lagging strand; relocalizes to the cytosol in response to hypoxia; member of the S. pombe RAD2/FEN1 family" /db_xref="GeneID:853747" /db_xref="SGD:S000001596" ORIGIN 1 mgikglnaii sehvpsairk sdiksffgrk vaidasmsly qfliavrqqd ggqltneage 61 ttshlmgmfy rtlrmidngi kpcyvfdgkp pdlksheltk rssrrvetek klaeattele 121 kmkqerrlvk vskehneeaq kllglmgipy iiapteaeaq caelakkgkv yaaasedmdt 181 lcyrtpfllr hltfseakke piheidtelv lrgldltieq fvdlcimlgc dycesirgvg 241 pvtalklikt hgsiekivef iesgesnntk wkipedwpyk qarmlfldpe vidgneinlk 301 wsppkekeli eylcddkkfs eervksgisr lkkglksgiq grldgffqvv pktkeqlaaa 361 akraqenkkl nknknkvtkg rr // LOCUS NP_012810 731 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding protein ABF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012810 VERSION NP_012810.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179678.1 REFERENCE 1 (residues 1 to 731) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 731) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 731) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 731) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 731) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09046. Method: conceptual translation. FEATURES Location/Qualifiers source 1..731 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..731 /product="DNA-binding protein ABF1" /calculated_mol_wt="81622" Region 7..731 /region_name="BAF1_ABF1" /note="BAF1 / ABF1 chromatin reorganizing factor; pfam04684" /db_xref="CDD:398385" CDS 1..731 /gene="ABF1" /locus_tag="YKL112W" /gene_synonym="BAF1; EBF2; OBF1; REB2; SBF1" /coded_by="NM_001179678.1:1..2196" /experiment="EXISTENCE:direct assay:GO:0000113 nucleotide-excision repair factor 4 complex [PMID:10601031]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:7663308|PMID:27016735]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:7663308]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194|PMID:3281162]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15522095]" /experiment="EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:11756546]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:11713306|PMID:10684934]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:7663308|PMID:3275867]" /experiment="EXISTENCE:direct assay:GO:0044374 sequence-specific DNA binding, bending [PMID:8206955]" /experiment="EXISTENCE:direct assay:GO:0070911 global genome nucleotide-excision repair [PMID:15177043]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:10684934|PMID:11713306]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15192094]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:15522095]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:8582634|PMID:16908533]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15192094]" /experiment="EXISTENCE:mutant phenotype:GO:0070911 global genome nucleotide-excision repair [PMID:10601031]" /note="DNA binding protein with possible chromatin-reorganizing activity; involved in transcriptional activation, gene silencing, and DNA replication and repair" /db_xref="GeneID:853748" /db_xref="SGD:S000001595" ORIGIN 1 mdklvvnyye ykhpiinkdl aigahggkkf ptlgawydvi neyefqtrcp iilknshrnk 61 hftfachlkn cpfkvllsya gnaassetss psannntnpp gtpdhihhhs nnmnnedndn 121 nngsnnkvsn dskldfvtdd leyhlanthp ddtndkvesr snevngnndd dadannifkq 181 qgvtikndte ddsinkasid rglddesgpt hgndsgnhrh needdvhtqm tknysdvvnd 241 edinvaiana vanvdsqsnn khdgkdddat nnndgqdnnt nndhnnnsni nnnnvgshgi 301 sshspssird tsmnldvfns atddipgpfv vtkiepyhsh plednlslgk filtkipkil 361 qndlkfdqil essynnsnht vskfkvshyv eesglldilm qrygltaedf ekrllsqiar 421 rittykarfv lkkkkmgeyn dlqpssssnn nnnndgelsg tnlrsnsidy akhqeissag 481 tssnttknvn nnkndsnddn ngnnnndasn lmesvldkts shryqpkkmp svnkwskpdq 541 ithsdvsmvg ldesndggne nvhptlaevd aqearetaql aidkinsykr siddkngdgh 601 nnssrnvvde nlindmdsed ahkskrqhls ditleerned dklphevaeq lrllsshlke 661 venlhqnndd dvddvmvdvd vesqynkntt hhnnhhsqph hdeedvagli gkaddeedls 721 deniqpelrg q // LOCUS NP_012812 313 aa linear PLN 30-JUN-2025 DEFINITION Kti12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012812 VERSION NP_012812.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179676.1 REFERENCE 1 (residues 1 to 313) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 313) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 313) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 313) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09047. Method: conceptual translation. FEATURES Location/Qualifiers source 1..313 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..313 /product="Kti12p" /calculated_mol_wt="35191" Region 3..309 /region_name="KTI12" /note="Chromatin associated protein KTI12; pfam08433" /db_xref="CDD:400643" CDS 1..313 /gene="KTI12" /locus_tag="YKL110C" /gene_synonym="TOT4" /coded_by="NM_001179676.1:1..942" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:15772087]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12139626]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15772087]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /note="Protein that plays a role in modification of tRNA wobble nucleosides; protein plays role in tRNA wobble nucleoside modification with Elongator complex; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p" /db_xref="GeneID:853750" /db_xref="SGD:S000001593" ORIGIN 1 mplvlftgyp csgkttlakh lvqllqskid atpslskysi tyhsdeslgi khsdyitsqd 61 erklrseiis avkrdlsknk ivivdslnyi kgfryqlhce vknlsttfcv iqtlcppeti 121 fewnktsnpn pwepellnql iqryeepnss nrwdsplfai ltpqdnitdy iddickvvfq 181 tsksaknsgh ndplskglqk pnsatvlkpa sqsnfiqvld ietskiikti mnhiksltsi 241 ggvsngtrvi vsegitdind dgcffvdlpi gnvvtlaqlq rlkrqfinfn klrdidqdri 301 gplfadylnk nln // LOCUS NP_012813 554 aa linear PLN 30-JUN-2025 DEFINITION transcription factor HAP4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012813 VERSION NP_012813.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179675.1 REFERENCE 1 (residues 1 to 554) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 554) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 554) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09048. Method: conceptual translation. FEATURES Location/Qualifiers source 1..554 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..554 /product="transcription factor HAP4" /calculated_mol_wt="62281" CDS 1..554 /gene="HAP4" /locus_tag="YKL109W" /coded_by="NM_001179675.1:1..1665" /experiment="EXISTENCE:direct assay:GO:0016602 CCAAT-binding factor complex [PMID:2676721]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11423663]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:2123465]" /experiment="EXISTENCE:mutant phenotype:GO:0043457 regulation of cellular respiration [PMID:2676721]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2676721]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11423663]" /note="Transcription factor; subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex; involved in diauxic shift" /db_xref="GeneID:853751" /db_xref="SGD:S000001592" ORIGIN 1 mtaktfllqa sasrprsnhf knehnnipla pvpiapntnh hnnsslefen dgskkkkkss 61 lvvrtskhwv lpprprpgrr ssshntlpan ntnnilnvgp nsrnssnnnn nnniisnrkq 121 askekrkipr hiqtidekli ndsnylaflk fddlenekfh ssassissps ysspsfssyr 181 nrkksefmdd esctdvetia ahnslltknh hidsssnvha pptkksklnd fdllslssts 241 ssatpvpqlt kdlnmnlnfh kiphkasfpd spadfspads vslirnhslp tnlqvkdkie 301 dlneikffnd fekleffnky akvntnndvn enndlwnsyl qsmddttgkn sgnyqqvdnd 361 dnmsllnlpi leetvssgqd dkvepdeedi wnylpssssq qedssralkk ntnsekaniq 421 akndetylfl qdqdesadsh hhdelgseit ladnkfsylp ptleelmeeq dcnngrsfkn 481 fmfsndtgid gsagtdddyt kvlkskkist sksnanlydl ndnnndatat neldqssfid 541 dldedvdflk vqvf // LOCUS NP_012814 453 aa linear PLN 30-JUN-2025 DEFINITION Sld2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012814 VERSION NP_012814.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179674.1 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 453) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09049. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..453 /product="Sld2p" /calculated_mol_wt="52141" Region 9..453 /region_name="Drc1-Sld2" /note="DNA replication and checkpoint protein; pfam11719" /db_xref="CDD:371692" CDS 1..453 /gene="SLD2" /locus_tag="YKL108W" /gene_synonym="DRC1" /coded_by="NM_001179674.1:1..1362" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:21109535]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:21109535]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:20231317]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:17167417|PMID:17167415]" /experiment="EXISTENCE:genetic interaction:GO:0031261 DNA replication preinitiation complex [PMID:20231317]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0003688 DNA replication origin binding [PMID:21109535]" /experiment="EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:21109535]" /experiment="EXISTENCE:mutant phenotype:GO:0031333 negative regulation of protein-containing complex assembly [PMID:24307213]" /experiment="EXISTENCE:mutant phenotype:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:10097122]" /experiment="EXISTENCE:mutant phenotype:GO:0071163 DNA replication preinitiation complex assembly [PMID:20231317]" /note="Single-stranded DNA origin-binding and annealing protein; required for initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component of the preloading complex; binds the Mcm2-7p complex to prevent inappropriate Mcm2-7p interaction with the GINS complex in G1; required for S phase checkpoint; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:853752" /db_xref="SGD:S000001591" ORIGIN 1 mysfeldklk ielktwehdf idknkreptr ddikslrtvr qmykqystlk kkqslqrqkv 61 dtqesvelpa hkkdhdevve igptpqvygk aisifdmnls pikpiymtft nnidvnndns 121 ktisnesspr ktillksspa drtlvaepis svkrqlnfqm lnasstrtpt sspcknrngk 181 lveikkcspt inpplesgkp sgyygpnspl kldeenihln islnsstkrr lqiaypslqk 241 tpskdqadis tsfspsplir rpltksliel arehteivke fgvlqeedie eeeegeegen 301 gydeknhedd fgledelirp kvvkdifqed ddnddsqare dtfirkrpkr rkvirrlrdn 361 dpetetagfe rdvhkelvkl krrkvaeflg stsqisdtef ehdpeassgv vsseqkptak 421 rkgrkkynlv snnfrrlklp kknrfsngrw grr // LOCUS NP_012815 309 aa linear PLN 30-JUN-2025 DEFINITION putative short-chain dehydrogenase/reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012815 VERSION NP_012815.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179673.1 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 309) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09050. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..309 /product="putative short-chain dehydrogenase/reductase" /calculated_mol_wt="34393" Region 26..285 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" Site order(30,32..33,35,54..56,99..101,161,180,184,208..211) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:187535" CDS 1..309 /locus_tag="YKL107W" /coded_by="NM_001179673.1:1..930" /experiment="EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:31115629]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:31115629]" /experiment="EXISTENCE:mutant phenotype:GO:1901426 response to furfural [PMID:31115629]" /note="NADH-dependent aldehyde reductase; involved in the detoxification of acetaldehyde, glycolaldehyde, furfural, formaldehyde and propionaldehyde; localizes to the endoplasmic reticulum; member of the classical short-chain dehydrogenase/reductase (SDR) family" /db_xref="GeneID:853753" /db_xref="SGD:S000001590" ORIGIN 1 mfwkkdptvs werknindid fsrfnvaiig gtgglgrais relaqrnarv tvvgqtfrde 61 dlkdkinfvk adlslvseck rishsdeipy eelthliftt gifasrqrqa tseglekdma 121 vsylsryiif hdvakrlgis rtkkddlpkv fiagfpgngq vgdpddlnsd ekkysayath 181 mntvaanesl vidakdrytn idtfglnpgl iktnirnnll gsdtylsrit ewiiswtcqs 241 aetyaktict liaspaiesr sgtmfsnkgd ailpspgltk dvvekfmens ellvekalrn 301 qspftssne // LOCUS NP_076898 39 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKL106C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_076898 VERSION NP_076898.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184482.1 REFERENCE 1 (residues 1 to 39) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 39) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 39) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 39) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 39) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09051. Method: conceptual translation. FEATURES Location/Qualifiers source 1..39 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..39 /product="uncharacterized protein" /calculated_mol_wt="4546" CDS 1..39 /locus_tag="YKL106C-A" /coded_by="NM_001184482.1:1..120" /note="hypothetical protein; identified by homology to uncharacterized proteins in other fungi" /db_xref="GeneID:853754" /db_xref="SGD:S000007616" ORIGIN 1 mpfpsilhlt igryasydsn nhmrrraklm eaifrirti // LOCUS NP_012816 451 aa linear PLN 30-JUN-2025 DEFINITION aspartate transaminase AAT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012816 VERSION NP_012816.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179672.1 REFERENCE 1 (residues 1 to 451) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 451) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 451) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 451) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09052. Method: conceptual translation. FEATURES Location/Qualifiers source 1..451 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..451 /product="aspartate transaminase AAT1" /EC_number="2.6.1.1" /calculated_mol_wt="51665" Region 16..446 /region_name="AAT_I" /note="Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl18945" /db_xref="CDD:450240" Site order(128..130,155,216,247,283,285..286,294) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99734" Site order(131,165,240,292..294,343,346) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:99734" Site 286 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99734" CDS 1..451 /gene="AAT1" /locus_tag="YKL106W" /coded_by="NM_001179672.1:1..1356" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:22010850|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:1901605 alpha-amino acid metabolic process [PMID:33397945]" /note="Mitochondrial aspartate aminotransferase; catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis" /db_xref="GeneID:853755" /db_xref="SGD:S000001589" ORIGIN 1 mlrtrltncs lwrpyytssl srvprappdk vlglsehfkk vknvnkidlt vgiykdgwgk 61 vttfpsvaka qklieshlel nknlsylpit gskefqenvm kflfkescpq fgpfylahdr 121 isfvqtlsgt galavaakfl alfisrdiwi pdpswanhkn ifqnngfeni yrysyykdgq 181 ididgwieql ktfaynnqqe nnknppciil hacchnptgl dptkeqweki idtiyelkmv 241 pivdmayqgl esgnllkday llrlclnvnk ypnwsngifl cqsfaknmgl ygervgslsv 301 itpatanngk fnplqqknsl qqnidsqlkk ivrgmysspp gygsrvvnvv lsdfklkqqw 361 fkdvdfmvqr lhhvrqemfd rlgwpdlvnf aqqhgmfyyt rfspkqveil rnnyfvyltg 421 dgrlslsgvn dsnvdylces leavskmdkl a // LOCUS NP_012817 1132 aa linear PLN 30-JUN-2025 DEFINITION Seg2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012817 VERSION NP_012817.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179671.1 REFERENCE 1 (residues 1 to 1132) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1132) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1132) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1132) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09053. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1132 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1132 /product="Seg2p" /calculated_mol_wt="125463" Region <293..>383 /region_name="PRK03918" /note="DNA double-strand break repair ATPase Rad50" /db_xref="CDD:235175" CDS 1..1132 /gene="SEG2" /locus_tag="YKL105C" /coded_by="NM_001179671.1:1..3399" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Eisosome component; likely plays only a minor role in eisosome assembly; shown to interact with Seg1p by affinity purification and mass spec; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; similar to A. gossypii SEG gene which is important for stabilizing eisosomes; SEG2 has a paralog, SEG1, that arose from the whole genome duplication" /db_xref="GeneID:853756" /db_xref="SGD:S000001588" ORIGIN 1 miqesspdal aaaaaignal syngrtvdks kipqynqsft srttsiagin rytmlsnsrt 61 nsrmllmngn vrqyskrtss lpnqghknts nnsagrrqhr ahedaettfr efggkqsskv 121 lnissstgqn sksrttslgn sgstirtikk yipgprglma vevpvevepp ryslsnrsnq 181 rggrayslpt rnnktslmhr nkttkkagsq ekksesggks kndyhgkvls kmhttslkqr 241 hnnvpliptt mneeteqelq edlhdplefk pmiisddens fiepsvldrs ipkkdksgls 301 grekkeeiet llkevhslee kisnieiakl neeereqsli lelrkvklde errmellkre 361 lnivkenadl eaqelklies krkqhfhkgq evasevksit irqptlsepk payvppedve 421 kepstlsnqt qnienaenid svdaegnlvd pillgslnns nfhmnsdnev rciadsnslt 481 gselsdynyi egsatdlrat aktsveseig gnqvglkipq dddsekqeer tkgkksglvd 541 tncflvqked qeealsdnep essekfpsts gienvklede tgsvmdknng pnndkddddd 601 kdndnddddd kdddvndddk denvdddenv dddddddddd ddeyhdsydv imrdpvqieq 661 disdvpslkh pseysteted nkkkeqnsen aevsqsgtnm akylrganpy ltntssdtfs 721 ldsenvnsks stdttrvapd llksslqpql rsdlkqsavp sstsssiysi etspnidsst 781 gktasntktn shgpptsisk qkydqssshq ipvmspkrld dkrkitnrsc lrtlrgssne 841 atlshnivyp asdssssppy hskkpsnpps sgnlasheas kcfpkapqas ttsrrlpdhv 901 plyidknnsa lypkeppark ssfekerpak dnlgfrsmsl replitknat ataaenldve 961 ekkekgghvs rkswtfglps plkrrtshst httneteivn pmtnfknktn endmpilank 1021 kscnnddssp ytassmntnd vseagteghr fslfgnksql snrnisggta tlessnpdlp 1081 talplsvpvt iidkngeihk lhnddaaikd kshdrhghsk fgrklkkifg rk // LOCUS NP_012818 717 aa linear PLN 30-JUN-2025 DEFINITION glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012818 VERSION NP_012818.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179670.1 REFERENCE 1 (residues 1 to 717) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 717) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 717) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 717) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09054. Method: conceptual translation. FEATURES Location/Qualifiers source 1..717 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..717 /product="glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1" /EC_number="2.6.1.16" /calculated_mol_wt="79916" Region 1..717 /region_name="PLN02981" /note="glucosamine:fructose-6-phosphate aminotransferase" /db_xref="CDD:215531" CDS 1..717 /gene="GFA1" /locus_tag="YKL104C" /coded_by="NM_001179670.1:1..2154" /experiment="EXISTENCE:direct assay:GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity [PMID:2656689]" /experiment="EXISTENCE:genetic interaction:GO:0006031 chitin biosynthetic process [PMID:11895440]" /note="Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication" /db_xref="GeneID:853757" /db_xref="SGD:S000001587" ORIGIN 1 mcgifgycny lversrgeii dtlvdglqrl eyrgydstgi aidgdeadst fiykqigkvs 61 alkeeitkqn pnrdvtfvsh cgiahtrwat hgrpeqvnch pqrsdpedqf vvvhngiitn 121 frelktllin kgykfesdtd teciaklylh lyntnlqngh dldfheltkl vllelegsyg 181 llckschypn eviatrkgsp lligvksekk lkvdfvdvef peenagqpei plksnnksfg 241 lgpkkarefe agsqnanllp iaanefnlrh sqsraflsed gsptpveffv ssdaasvvkh 301 tkkvlfledd dlahiydgel hihrsrrevg asmtrsiqtl emelaqimkg pydhfmqkei 361 yeqpestfnt mrgridyenn kvilgglkaw lpvvrrarrl imiacgtsyh sclatraife 421 elsdipvsve lasdfldrkc pvfrddvcvf vsqsgetadt mlalnycler galtvgivns 481 vgssisrvth cgvhinagpe igvastkayt sqyialvmfa lslsddrvsk idrrieiiqg 541 lklipgqikq vlkleprikk lcatelkdqk sllllgrgyq faaalegalk ikeisymhse 601 gvlagelkhg vlalvdenlp iiafgtrdsl fpkvvssieq vtarkghpii icnendevwa 661 qksksidlqt levpqtvdcl qgliniiplq lmsywlavnk gidvdfprnl aksvtve // LOCUS NP_001381967 84 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKL104W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381967 VERSION NP_001381967.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395037.1 REFERENCE 1 (residues 1 to 84) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 84) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 84) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 84) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54808. Method: conceptual translation. FEATURES Location/Qualifiers source 1..84 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..84 /product="uncharacterized protein" /calculated_mol_wt="9435" CDS 1..84 /locus_tag="YKL104W-A" /coded_by="NM_001395037.1:1..255" /note="Novel ORF identified by enrichment-based proteomics" /db_xref="GeneID:65052911" /db_xref="SGD:S000303811" ORIGIN 1 mndhklvfwv rslrvtvnlf wstvsspssm rnttmrdksn vsvrillsnl lfqsthftdl 61 lidesrisfv tidsntggii asif // LOCUS NP_012819 514 aa linear PLN 30-JUN-2025 DEFINITION metalloaminopeptidase APE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012819 VERSION NP_012819.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179669.1 REFERENCE 1 (residues 1 to 514) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 514) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 514) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 514) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09055. Method: conceptual translation. FEATURES Location/Qualifiers source 1..514 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..514 /product="metalloaminopeptidase APE1" /EC_number="3.4.11.22" /calculated_mol_wt="56962" Region 53..502 /region_name="M18" /note="M18 peptidase aminopeptidase family; cd05639" /db_xref="CDD:349892" Site order(132,303..304,339..340,385..386,388,413,420,453..454, 478..479) /site_type="active" /db_xref="CDD:349892" CDS 1..514 /gene="APE1" /locus_tag="YKL103C" /gene_synonym="API; LAP4; YSC1" /coded_by="NM_001179669.1:1..1545" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:1400574]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0034270 Cvt complex [PMID:20659891|PMID:9412464|PMID:9151668]" /experiment="EXISTENCE:direct assay:GO:0070006 metalloaminopeptidase activity [PMID:3882418]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:18725539]" /note="Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to peptidase family M18; often used as marker in studies of autophagy and cytosol to vacuole targeting (CVT) pathway; protein increases in abundance and relative distribution to cytoplasmic foci increases upon DNA replication stress; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway and via CVT pathway" /db_xref="GeneID:853758" /db_xref="SGD:S000001586" ORIGIN 1 meeqreileq lkktlqmltv epsknnqian eekekkenen swcilehnye diaqefidfi 61 yknpttyhvv sffaelldkh nfkylseksn wqdsigedgg kfytirngtn lsafilgknw 121 raekgvgvig shvdaltvkl kpvsfkdtae gygriavapy ggtlnelwld rdlgiggrll 181 ykkkgtneik salvdstplp vcripslaph fgkpaegpfd kedqtipvig fptpdeegne 241 pptddekksp lfgkhcihll ryvaklagve vseliqmdld lfdvqkgtig gigkhflfap 301 rlddrlcsfa amialicyak dvnteesdlf stvtlydnee igsltrqgak ggllesvver 361 sssaftkkpv dlhtvwansi ilsadvnhly npnfpevylk nhfpvpnvgi tlsldpnghm 421 atdvvgtalv eelarrngdk vqyfqiknns rsggtigpsl asqtgartid lgiaqlsmhs 481 iraatgskdv glgvkffngf fkhwrsvyde fgel // LOCUS NP_001335789 101 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKL102C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335789 VERSION NP_001335789.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348849.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 101) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80309. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..101 /product="uncharacterized protein" /calculated_mol_wt="11292" CDS 1..101 /locus_tag="YKL102C" /coded_by="NM_001348849.1:1..306" /note="hypothetical protein; conserved across S. cerevisiae strains; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site" /db_xref="GeneID:853759" /db_xref="SGD:S000001585" ORIGIN 1 mcalfaevss taaascsfgv llcsgsncgr lvgserrkvl yvfnvnvckk mssyyflrhd 61 nivipyllrl lvsdkeasnk npllpflmdk ershhfvrnm n // LOCUS NP_012821 1518 aa linear PLN 30-JUN-2025 DEFINITION protein kinase HSL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012821 VERSION NP_012821.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179667.2 REFERENCE 1 (residues 1 to 1518) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1518) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1518) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1518) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09056. On Apr 26, 2011 this sequence version replaced NP_012821.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1518 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1518 /product="protein kinase HSL1" /EC_number="2.7.11.1" /calculated_mol_wt="169476" Region 79..369 /region_name="STKc_BRSK1_2" /note="Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; cd14081" /db_xref="CDD:270983" Site order(87..91,95,108,110,177,193..196,200,202..203,205, 238..239,241,243..244,246,257..258,261,275..279,281, 311..314) /site_type="active" /db_xref="CDD:270983" Site order(87..90,95,108,110,177,193..196,200,243..244,246, 257..258) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270983" Site order(200,202..203,205,239,241,243,261,275..279,281, 311..314) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270983" Site order(257..268,270..279) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270983" Region 1347..1517 /region_name="AMPKA_C_like" /note="C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains; cl17070" /db_xref="CDD:473060" CDS 1..1518 /gene="HSL1" /locus_tag="YKL101W" /gene_synonym="ELM2; NIK1" /coded_by="NM_001179667.2:1..4557" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:27053666|PMID:9925642]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:9925642|PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:11408575|PMID:39009344]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10805747|PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0006651 diacylglycerol biosynthetic process [PMID:39009344]" /experiment="EXISTENCE:direct assay:GO:1900481 negative regulation of diacylglycerol biosynthetic process [PMID:39009344]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10490630]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:11408575]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:23042131]" /experiment="EXISTENCE:mutant phenotype:GO:0044879 mitotic morphogenesis checkpoint signaling [PMID:9925642]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:8647431]" /experiment="EXISTENCE:mutant phenotype:GO:1902935 protein localization to septin ring [PMID:27053666]" /experiment="EXISTENCE:physical interaction:GO:0000144 cellular bud neck septin ring [PMID:9925642]" /note="Nim1p-related protein kinase; septin-binding kinase that localizes to the bud neck septin ring and regulates the morphogenesis checkpoint; phosphorylates Hsl7p and cooperates with Elm1p to recruit Hsl7p to the mother-bud neck, as a prerequisite for the subsequent recruitment, phosphorylation, and degradation of Swe1p; phosphorylates and inhibits Pah1p, a phosphatidate phosphatase to regulate lipid synthesis; autophosphorylation enhances interactions with Hsl7p" /db_xref="GeneID:853760" /db_xref="SGD:S000001584" ORIGIN 1 mtghvsktsh vpkgrpssla kkaakramak vnsnpkrasg hlervvqsvn datkrlsqpd 61 stvsvatkss krksrdtvgp wklgktlgkg ssgrvrlakn metgqlaaik ivpkkkafvh 121 csnngtvpns ysssmvtsnv sspsiasreh snhsqtnpyg iereivimkl ishtnvmalf 181 evwenksely lvleyvdgge lfdylvskgk lpereaihyf kqivegvsyc hsfnichrdl 241 kpenllldkk nrrikiadfg maalelpnkl lktscgsphy aspeivmgrp yhggpsdvws 301 cgivlfallt ghlpfnddni kklllkvqsg kyqmpsnlss eardliskil vidpekritt 361 qeilkhplik kyddlpvnkv lrkmrkdnma rgksnsdlhl lnnvspsivt lhskgeides 421 ilrslqilwh gvsrelitak llqkpmseek lfyslllqyk qrhsislsss senkksates 481 svneprieya sktanntglr senndvktlh sleihsedts tvnqnnaitg vnteinapvl 541 aqksqfsint lsqpesdkae aeavtlppai pifnasssri frnsytsiss rsrrslrlsn 601 srlslsasts retvhdnemp lpqlpkspsr yslsrraiha spstksihks lsrkniaatv 661 aarrtlqnsa skrslyslqs iskrslnlnd llvfddplps kkpasenvnk sephslesds 721 dfeilcdqil fgnaldrile eeednekerd tqrqrqndtk ssadtftisg vstnkenegp 781 eyptkieknq fnmsykpsen msglssfpif ekentlsssy leeqkpkraa lsditnsfnk 841 mnkqegmrie kkiqreqlqk kndrpsplkp iqhqelrvns lpndqgkpsl sldprrnisq 901 pvnskvesll qglkfkkepa shwthergsl fmsehvedek pvkasdvsie ssyvplttva 961 tssrdpsvla esstiqkpml slpssflnts mtfknlsqil addgddkhls vpqnqsrsva 1021 mshplrkqsa kisltprsnl nanlsvkrnq gspgsylsnd ldgisdmtfa meiptntfta 1081 qaiqlmnndt dnnkintspk assftkekvi ksaayiskek epdnsdtnyi pdytipntyd 1141 ekainifeda psdegslnts ssesdsrasv hrkavsidtm attnvltpat nvrvslywnn 1201 nssgiprett eeilsklrls penpsnthmq krfsstrgsr dsnalgisqs lqsmfkdlee 1261 dqdghtsqad ilessmsysk rrpseesvnp kqrvtmlfde eeeeskkvgg gkikeehtkl 1321 dnkiseessq lvlpvvekke nanntennys kipkpstikv tkdtamesnt qthtkkpilk 1381 svqnveveea pssdkknwfv klfqnfsshn natkasknhv tnisfddahm ltlnefnkns 1441 idyqlknldh kfgrkvveyd ckfvkgnfkf kikitstpna stvitvkkrs khsntssnka 1501 fekfnddver virnagrs // LOCUS NP_012822 587 aa linear PLN 30-JUN-2025 DEFINITION aspartic endopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012822 VERSION NP_012822.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179666.1 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 587) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09057. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..587 /product="aspartic endopeptidase" /calculated_mol_wt="67394" Region 148..510 /region_name="Peptidase_A22B" /note="Signal peptide peptidase; pfam04258" /db_xref="CDD:282158" CDS 1..587 /gene="YPF1" /locus_tag="YKL100C" /coded_by="NM_001179666.1:1..1764" /experiment="EXISTENCE:direct assay:GO:1990578 perinuclear endoplasmic reticulum membrane [PMID:25454947]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:25454947]" /experiment="EXISTENCE:mutant phenotype:GO:0042500 aspartic endopeptidase activity, intramembrane cleaving [PMID:25454947]" /experiment="EXISTENCE:mutant phenotype:GO:0051603 proteolysis involved in protein catabolic process [PMID:25454947]" /note="Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters, such as Ctr1p and Zrt1p, during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase (SPP)" /db_xref="GeneID:853761" /db_xref="SGD:S000001583" ORIGIN 1 mdkylnsfvd hlsewssraf rnnsssanqs asnkeleqvf eqinaivenh nnklttafdk 61 isyrvahkit hlveshslvf nyatlvlias alvvigsfts issipftalp ptrehslfdp 121 tdfdvdhdch viyrendedk kkkkkskrff dmmdekhaii lpltsgctll alyfvikklh 181 lnwlkyvvki lnfnitllni pagtfvysyf lnslfrnlsh laswnplvvl pryrvtiadd 241 nedlnkiggf vtnlnykdgl tnsvvhkktl deiekdhwmk hfyrrelvep kdikskrqis 301 nmylnsaliv sfvlsivstv yfylspndwl isnavsmnma iwsiaqlklk nlksgalili 361 alffydicfv fgtdvmvtva tnldipvkls lpvkfntaqn nfnfsilglg dialpgmfia 421 mcykydiwkw hldhddtefh flnwsyvgky fitamvsyva slvsamvsls ifntaqpall 481 yivpsllist ilvacwnkdf kqfwnfqydt ievdkslkka iekkensity stfilseyyn 541 dadkyallgd dvnenfddde efvqeedlsd sseeelseed llddess // LOCUS NP_012823 250 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein UTP11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012823 VERSION NP_012823.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179665.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 250) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09058. On Dec 19, 2005 this sequence version replaced NP_012823.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..250 /product="rRNA-processing protein UTP11" /calculated_mol_wt="29604" Region 1..250 /region_name="COG5223" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227548" CDS 1..250 /gene="UTP11" /locus_tag="YKL099C" /coded_by="NM_001179665.1:1..753" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /note="Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit" /db_xref="GeneID:853762" /db_xref="SGD:S000001582" ORIGIN 1 maklvhdvqk kqhrersqlt srsrygflek hkdyvkraqd fhrkqstlkv lrekakernp 61 deyyhamhsr ktdakgllis srhgdeedes lsmdqvkllk tqdsnyvrtl rqielkklek 121 gakqlmfkss gnhtifvdsr ekmneftpek ffnttsemvn rsenrltkdq laqdisnnrn 181 assimpkesl dkkklkkfkq vkqhlqretq lkqvqqrmda qrellkkgsk kkivdssgki 241 sfkwkkqrkr // LOCUS NP_012824 357 aa linear PLN 30-JUN-2025 DEFINITION Mtc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012824 VERSION NP_012824.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179664.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 357) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09059. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..357 /product="Mtc2p" /calculated_mol_wt="39711" CDS 1..357 /gene="MTC2" /locus_tag="YKL098W" /coded_by="NM_001179664.1:1..1074" /note="hypothetical protein; mtc2 is synthetically sick with cdc13-1" /db_xref="GeneID:853763" /db_xref="SGD:S000001581" ORIGIN 1 mgdhnlpdfq tclkfsvtak ksflcmyrds vskeklassm pstcdiqlkr aindaypggg 61 ikvtvlnstt asldslatth vkefeiviip dinsllqpdq aklvkimrdc tvaiekaqst 121 rifigvvhwn npvqpsgaak dgdeagkpap ktriflptsf rmgawlkhkf wfacappyld 181 fesstessin trannsigma eeekqepesk rsiilneean lndvfvgstv rryildimvh 241 lrthrltyna kaggvytnsl ddvvllsrli glhsgkmfvs pshvkeasrw yfpmhlelvq 301 rssmdsslly gsdpnlvdem leklakikce evnefenplf leslvvknvl skvvppv // LOCUS NP_001335790 136 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKL097C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335790 VERSION NP_001335790.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348850.1 REFERENCE 1 (residues 1 to 136) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 136) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 136) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 136) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80310. Method: conceptual translation. FEATURES Location/Qualifiers source 1..136 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..136 /product="uncharacterized protein" /calculated_mol_wt="15311" CDS 1..136 /locus_tag="YKL097C" /coded_by="NM_001348850.1:1..411" /note="hypothetical protein; conserved across S. cerevisiae strains; not conserved in closely related Saccharomyces species" /db_xref="GeneID:853764" /db_xref="SGD:S000001580" ORIGIN 1 mflftftile sekliiwpvp avvlgvmapk raystpfgpw pgpaeclwnc pselrqfssc 61 clplpklrpp rptfaslwrv vaaiaalfqv pwrrktgvgk aifcigcccl ayqwrrtryf 121 aykimtgtcf mtdlap // LOCUS NP_878110 49 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKL096C-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878110 VERSION NP_878110.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184604.1 REFERENCE 1 (residues 1 to 49) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 49) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 49) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 49) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09060. Method: conceptual translation. FEATURES Location/Qualifiers source 1..49 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..49 /product="uncharacterized protein" /calculated_mol_wt="5857" CDS 1..49 /locus_tag="YKL096C-B" /coded_by="NM_001184604.1:1..150" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1500486" /db_xref="SGD:S000028667" ORIGIN 1 mklfildyek krtkigkgma rrelkmmnkk pdlytiivsy fsifslfff // LOCUS NP_012826 92 aa linear PLN 30-JUN-2025 DEFINITION Cwp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012826 VERSION NP_012826.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180025.1 REFERENCE 1 (residues 1 to 92) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 92) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 92) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 92) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09061. Method: conceptual translation. FEATURES Location/Qualifiers source 1..92 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..92 /product="Cwp2p" /calculated_mol_wt="8780" CDS 1..92 /gene="CWP2" /locus_tag="YKL096W-A" /gene_synonym="LPR1; YKL097W-A" /coded_by="NM_001180025.1:1..279" /experiment="EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:7768807]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11956747]" /experiment="EXISTENCE:direct assay:GO:0031505 fungal-type cell wall organization [PMID:7768807]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:7768807|PMID:31537451]" /note="Covalently linked cell wall mannoprotein; major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored" /db_xref="GeneID:853765" /db_xref="SGD:S000001956" ORIGIN 1 mqfstvasva fvalanfvaa esaaaisqit dgqiqattta tteatttaap sstvetvsps 61 stetisqqte ngaakaavgm gagalaaaam ll // LOCUS NP_012827 239 aa linear PLN 30-JUN-2025 DEFINITION Cwp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012827 VERSION NP_012827.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179662.1 REFERENCE 1 (residues 1 to 239) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 239) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 239) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 239) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09062. Method: conceptual translation. FEATURES Location/Qualifiers source 1..239 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..239 /product="Cwp1p" /calculated_mol_wt="24137" CDS 1..239 /gene="CWP1" /locus_tag="YKL096W" /gene_synonym="YJU1" /coded_by="NM_001179662.1:1..720" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:7768807]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18756268]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9335273|PMID:15781460]" /experiment="EXISTENCE:direct assay:GO:0031505 fungal-type cell wall organization [PMID:7768807]" /experiment="EXISTENCE:direct assay:GO:0071597 cellular birth scar [PMID:16672383]" /experiment="EXISTENCE:genetic interaction:GO:0032120 ascospore-type prospore membrane formation [PMID:18756268]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:7768807]" /note="Cell wall mannoprotein that localizes to birth scars of daughter cells; linked to beta-1,3- and beta-1,6-glucan heteropolymer through phosphodiester bond; required for propionic acid resistance; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:853766" /db_xref="SGD:S000001579" ORIGIN 1 mkfstalsva lfalakmvia dseefglvsi rsgsdlqyls vysdngtlkl gsgsgsfeat 61 itddgklkfd ddkyavvned gsfkegsesd aatgfsikdg hlnyksssgf yaikdgssyi 121 fsskqsddat gvairptsks gsvaadfsps dssssssasa ssasassstk hsssiesvet 181 sttvetssas sptasvisqi tdgqiqapnt vyeqtenaga kaavgmgaga lavaaayll // LOCUS NP_012828 278 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein YJU2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012828 VERSION NP_012828.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179661.1 REFERENCE 1 (residues 1 to 278) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 278) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 278) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 278) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09063. Method: conceptual translation. FEATURES Location/Qualifiers source 1..278 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..278 /product="mRNA splicing protein YJU2" /calculated_mol_wt="32181" Region 7..278 /region_name="COG5134" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227463" CDS 1..278 /gene="YJU2" /locus_tag="YKL095W" /gene_synonym="CWC16" /coded_by="NM_001179661.1:1..837" /experiment="EXISTENCE:direct assay:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:17515604]" /experiment="EXISTENCE:direct assay:GO:0000384 first spliceosomal transesterification activity [PMID:17515604]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:17515604]" /note="Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC ('nineteen complex') and acts after Prp2p to promote the first catalytic reaction of splicing" /db_xref="GeneID:853767" /db_xref="SGD:S000001578" ORIGIN 1 mserkainky yppdynplea eklsrkmakk lktmnkshas irlmtpfsmr clecneyipk 61 srkfngkkel lkekyldsik iyrltiscpr cansiafrtd pgnsdyvmev ggvrnyvpqk 121 pnddlnakta vesidetlqr lvrekemeqn ekmgikeqad dkmdllekrl akiqqeqedd 181 eelenlrkkn lemsqraemi nrskhaqqek avttddldnl vdqvfdnhrq rtnkpgnnnd 241 ekrtplfnpt stkgkiqkks svrtnplgiv ikrgkslk // LOCUS NP_012829 313 aa linear PLN 30-JUN-2025 DEFINITION acylglycerol lipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012829 VERSION NP_012829.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179660.1 REFERENCE 1 (residues 1 to 313) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 313) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 313) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 313) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09064. Method: conceptual translation. FEATURES Location/Qualifiers source 1..313 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..313 /product="acylglycerol lipase" /EC_number="3.1.1.23" /calculated_mol_wt="35432" Region 38..289 /region_name="Hydrolase_4" /note="Serine aminopeptidase, S33; pfam12146" /db_xref="CDD:463473" CDS 1..313 /gene="YJU3" /locus_tag="YKL094W" /coded_by="NM_001179660.1:1..942" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:20554061|PMID:24868093|PMID:10515935]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:20554061]" /experiment="EXISTENCE:direct assay:GO:0017171 serine hydrolase activity [PMID:14645503]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006641 triglyceride metabolic process [PMID:20554061]" /experiment="EXISTENCE:mutant phenotype:GO:0047372 monoacylglycerol lipase activity [PMID:20554061]" /note="Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters; required for removal of toxic metabolites in ethanol producing yeast cells; localizes to lipid particles and membranes; member of the eukaryotic serine hydrolase family; functional ortholog of mammalian MGL" /db_xref="GeneID:853768" /db_xref="SGD:S000001577" ORIGIN 1 mapypykvqt tvpelqyenf dgakfgymfw pvqngtnevr grvllihgfg eytkiqfrlm 61 dhlslngyes ftfdqrgagv tspgrskgvt deyhvfndle hfveknlsec kakgiplfmw 121 ghsmgggicl nyacqgkhkn eisgyigsgp liilhphtmy nkptqiiapl lakflprvri 181 dtgldlkgit sdkayraflg sdpmsvplyg sfrqihdfmq rgaklyknen nyiqknfakd 241 kpviimhgqd dtindpkgse kfiqdcpsad kelklypgar hsifsletdk vfntvfndmk 301 qwldkhttte akp // LOCUS NP_012830 339 aa linear PLN 30-JUN-2025 DEFINITION Mbr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012830 VERSION NP_012830.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179659.1 REFERENCE 1 (residues 1 to 339) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 339) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 339) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 339) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09065. Method: conceptual translation. FEATURES Location/Qualifiers source 1..339 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..339 /product="Mbr1p" /calculated_mol_wt="36804" Region 29..248 /region_name="MBR1" /note="Mitochondrial biogenesis regulation protein 1; pfam17058" /db_xref="CDD:435712" CDS 1..339 /gene="MBR1" /locus_tag="YKL093W" /coded_by="NM_001179659.1:1..1020" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8208248]" /note="Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; MBR1 has a paralog, ISF1, that arose from the whole genome duplication" /db_xref="GeneID:853769" /db_xref="SGD:S000001576" ORIGIN 1 mrmekttdkp lsagdmndey srgpiddidc lnfferavqd pcceacdted adeelrakls 61 sfnfqpdssp cnakcqqtln plckidealp aeselapsrn gsvseansdt nsiastvhdp 121 vdskyggmps lrkakttsyf tssssnnttm rnplkkcntn ingllvngrs ssssrqsipe 181 lfsgactkkk nnvllksetp nsefssnslq hcnsrsfslp rsrsrssaia ipthlyglek 241 yvspgldtlt adpeesierf snnrpreiss ccpndtgdts sslshsntss slnfplgtnt 301 nqfhqprqpv qqqqsskpnf gagrkksfie mslassfag // LOCUS NP_012831 1104 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein BUD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012831 VERSION NP_012831.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179658.1 REFERENCE 1 (residues 1 to 1104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1104) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09066. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1104 /product="GTPase-activating protein BUD2" /calculated_mol_wt="126533" Region 337..444 /region_name="C2" /note="C2 domain; cd00030" /db_xref="CDD:175973" Region 460..819 /region_name="RasGAP_CLA2_BUD2" /note="Ras-GTPase Activating Domain of CLA2/BUD2; cd05137" /db_xref="CDD:213339" Site order(506,557,559,561..562,564,567,571,673,681..682, 685..686,689,710,713..714,717,721,723,728..729) /site_type="other" /note="putative RAS interface [polypeptide binding]" /db_xref="CDD:213339" CDS 1..1104 /gene="BUD2" /locus_tag="YKL092C" /gene_synonym="CLA2; ERC25" /coded_by="NM_001179658.1:1..3315" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10444589]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:8371782]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10444589|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:23783029]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:22558355|PMID:2065354]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:2065354]" /experiment="EXISTENCE:mutant phenotype:GO:0007163 establishment or maintenance of cell polarity [PMID:23783029]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:15645503]" /experiment="EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:22558355]" /experiment="EXISTENCE:mutant phenotype:GO:0036267 invasive filamentous growth [PMID:23783029]" /note="GTPase activating factor for Rsr1p/Bud1p; plays a role in spindle position checkpoint distinct from its role in bud site selection; required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types; contains two PH-like domains" /db_xref="GeneID:853770" /db_xref="SGD:S000001575" ORIGIN 1 mssnnepaqs rtsyfklnef lsnvkhyknt fkgeiqwcnn lslndwkthy lqitstgalt 61 hsideltads tniqpiikhl qqcrieiikd khssfkdina ncnfiiqvnt sgkdnkvylr 121 vkswsdfkkl ltcliwwssm ktngifnkfq vsrplefksk kmakpesllv yklnvfgpiv 181 knivlppatn ilespdiinn ddnsvgwfsa mgvlksngml dlllqsdgsl iyslnisqll 241 rseirildss vlqsenslfl gelpllrsql glekfrieni asaatnssdi sqeiivefpl 301 ridledcfia lqsfarseyl sitgsdksnd mkisnsfkis ileanfqsin lndknntpws 361 iftditawgh twartsmvsn ssnpfwreef qfnellrltn syleikqlfh dlnnkkrlrl 421 igkikitqei indtrynket rlpimdvdnk nfqigticik issnlnfilp stnfvklekl 481 lmnanlsmvs nliykssssm endnkltqts iifldifqsl srieewfhvl idkelakidg 541 tvsrinqknl dskhvfnslf rgnsiltksi eqyffrvgne ylskalsail keiiesnksc 601 eldparvkek devkkrkiia dnykrlyswv tkiwkrlyat sndlpieirn vlkifrqkle 661 iiciddtlqi ilngisgllf lrffcpviln pklfkyvsqn lnetarrnlt liskvllnls 721 tltqfankep wlmkmnnfid krhndlldyi dkmtqkkldf nskilnlsst isrpklaieq 781 tmlddlpqip ylldknlret efvnlivnfs qedmtkmeky nhmdnggkge lieeegllsg 841 sslnlsvdkk dldspievkp eigelefeki tennteifgd dlmnllksdd vgsrsrdldn 901 gansgikfns iipkaeeekh amkeleqesc llynrinhir krlsgyecas stlfedkkys 961 islshkifye eikegkeivl kllnkptnen ssarlqkfft kgvssksnnt vgdsyckflt 1021 idvsdenpks snktsvhgts sengakddyl tlpnsqgkgn lgnrfsptkl srimrkppna 1081 dvpkeqnsrk ltrwfkkkke tggs // LOCUS NP_012832 310 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol/phosphatidylcholine-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012832 VERSION NP_012832.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179657.1 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 310) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09067. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..310 /product="phosphatidylinositol/phosphatidylcholine-binding protein" /calculated_mol_wt="35942" Region 30..75 /region_name="CRAL_TRIO_N" /note="CRAL/TRIO, N-terminal domain; smart01100" /db_xref="CDD:215024" Region 101..271 /region_name="SEC14" /note="Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); smart00516" /db_xref="CDD:214706" CDS 1..310 /locus_tag="YKL091C" /gene_synonym="SFH1" /coded_by="NM_001179657.1:1..933" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12869188]" /experiment="EXISTENCE:direct assay:GO:0031210 phosphatidylcholine binding [PMID:18243114]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:18243114]" /note="Putative phosphatidylinositol/phosphatidylcholine transfer protein; possibly involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study; YKL091C has a paralog, SEC14, that arose from the whole genome duplication" /db_xref="GeneID:853771" /db_xref="SGD:S000001574" ORIGIN 1 mttsildtyp qicspnalpg tpgnltkeqe eallqfrsil leknykerld dstllrflra 61 rkfdinasve mfveterwre eygantiied yennkeaedk eriklakmyp qyyhhvdkdg 121 rplyfeelgg inlkkmykit tekqmlrnlv keyelfatyr vpacsrragy lietsctvld 181 lkgislsnay hvlsyikdva disqnyyper mgkfyiihsp fgfstmfkmv kpfldpvtvs 241 kifilgssyk kellkqipie nlpvkyggts vlhnpndkfy ysdigpwrdp ryigpegeip 301 nifgkftvts // LOCUS NP_012833 443 aa linear PLN 30-JUN-2025 DEFINITION Cue2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012833 VERSION NP_012833.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179656.1 REFERENCE 1 (residues 1 to 443) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 443) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 443) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 443) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09068. Method: conceptual translation. FEATURES Location/Qualifiers source 1..443 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..443 /product="Cue2p" /calculated_mol_wt="50743" Region 10..51 /region_name="CUE1_Cue2p_like" /note="CUE1 domain found in yeast ubiquitin-binding protein CUE2 (Cue2p) and similar proteins; cd14374" /db_xref="CDD:270557" Site order(15,18..21,38..41,43,47..48,50..51) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270557" Region 57..94 /region_name="CUE2_Cue2p_like" /note="CUE2 domain found in yeast ubiquitin-binding protein CUE2 (Cue2p) and similar proteins; cd14375" /db_xref="CDD:270558" Region 344..440 /region_name="SMR" /note="Small MutS-related domain; smart00463" /db_xref="CDD:214676" CDS 1..443 /gene="CUE2" /locus_tag="YKL090W" /coded_by="NM_001179656.1:1..1332" /experiment="EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:31219035]" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:31219035]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:31219035]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12787503|PMID:12628920]" /experiment="EXISTENCE:direct assay:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:31219035]" /note="Ubiquitin-binding endonuclease involved in mRNA decay; recruited to stalled ribosomes to promote breakdown of transcript body of nuclear-transcribed mRNA with stalls in translation elongation; cleaves mRNA within A site of colliding ribosome; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination" /db_xref="GeneID:853772" /db_xref="SGD:S000001573" ORIGIN 1 msmdnnddhe sklsilmdmf paisksklqv hllennndld ltiglllken ddkstvdnel 61 hqlydmfpql dcsvikdqfv ineksvesti sdllnyetlq klkdnqansp dsvkrnekkn 121 nwestndhie siikftdapk niaqeylaen gfdtvkaiik iildyydkrd fkkdvdtfkv 181 krspnttvrg grvqsstgla hvlkkgkesa nvaqeslkrp rsykhsldsp qmvelnelva 241 dnrdlkainh eflqkclqfy dgdvvkvlni ssllieddkn itktwnfdeg ftltsrdnck 301 qhlpkfstpq isrrnevgnt yklplhdket pegavpvinn lfqtyrldfh gflpseavst 361 lklalnkwws kevaerelns hninsygskv qfvsplivvt grgihsiggi skvrlqvksf 421 leknhyifwe essyfriegk kkk // LOCUS NP_012834 549 aa linear PLN 30-JUN-2025 DEFINITION Mif2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012834 VERSION NP_012834.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179655.1 REFERENCE 1 (residues 1 to 549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 549) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09069. Method: conceptual translation. FEATURES Location/Qualifiers source 1..549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..549 /product="Mif2p" /calculated_mol_wt="62342" Region 3..>35 /region_name="Mif2_N" /note="Kinetochore CENP-C fungal homolog, Mif2, N-terminal; pfam15624" /db_xref="CDD:434820" Region 439..526 /region_name="CENP-C_C" /note="Mif2/CENP-C like; pfam11699" /db_xref="CDD:403028" Site order(450..452,475..477,479,481,501,503,523,525,527) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:380398" CDS 1..549 /gene="MIF2" /locus_tag="YKL089W" /coded_by="NM_001179655.1:1..1650" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:9407032]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:18701705|PMID:9407032]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:14581449]" /experiment="EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:22561346]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:8408221]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:8408221]" /experiment="EXISTENCE:mutant phenotype:GO:0051382 kinetochore assembly [PMID:18701705]" /note="Centromeric CDEIII region binding protein; nucleates kinetochore assembly; required for the structural integrity of elongating spindles; copurifies with subunits of the MIND complex and centromeric nucleosome components (Cse4p and histones H2A, H2B, and H4); phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3; localizes to the kinetochore" /db_xref="GeneID:853773" /db_xref="SGD:S000001572" ORIGIN 1 mdymklglks rktgidvkqd ipkdeysmen iddffkddet slismrrksr rksslflpst 61 lngdtknvlp pflqsyksqd devvqspsgk gdgsrrssll shqsnflspa ndfepieeep 121 eqeendirgn dfatpitqkl skptykrkys trysldtses psvrltpdri tnknvysdvp 181 dlvadedddd rvntslntsd nalledeled dgfipeseed gdyiesdssl dsgsdsasds 241 dgdntyqeve eeaevntndn eddyirrqas dvvrtdsiid rnglrkstrv kvaplqywrn 301 ekivykrksn kpvldidkiv tydesedeee ilaaqrrkkq kkkptptrpy nyvptgrprg 361 rpkkdpnake nlipedpned iieriesggi engewlkhgi leanvkisdt keetkdeiia 421 fapnlsqteq vkdtkdenfa leimfdkhke yfasgilklp aisgqkklsn sfrtyitfhv 481 iqgivevtvc knkflsvkgs tfqipafney aianrgndea kmffvqvtvs edanddndke 541 ldstfdtfg // LOCUS NP_012835 571 aa linear PLN 30-JUN-2025 DEFINITION phosphopantothenoylcysteine decarboxylase complex subunit CAB3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012835 VERSION NP_012835.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179654.1 REFERENCE 1 (residues 1 to 571) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 571) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 571) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 571) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09070. Method: conceptual translation. FEATURES Location/Qualifiers source 1..571 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..571 /product="phosphopantothenoylcysteine decarboxylase complex subunit CAB3" /calculated_mol_wt="65107" Region 264..497 /region_name="Flavoprotein" /note="cl19190" /db_xref="CDD:450266" CDS 1..571 /gene="CAB3" /locus_tag="YKL088W" /coded_by="NM_001179654.1:1..1716" /experiment="EXISTENCE:direct assay:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071513 phosphopantothenoylcysteine decarboxylase complex [PMID:19915539]" /experiment="EXISTENCE:direct assay:GO:1990143 CoA-synthesizing protein complex [PMID:23789928]" /experiment="EXISTENCE:genetic interaction:GO:0015937 coenzyme A biosynthetic process [PMID:19915539|PMID:19266201]" /experiment="EXISTENCE:mutant phenotype:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]" /note="Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis; subunits of the phosphopantothenoylcysteine decarboxylase (PPCDC) complex are: Cab3p, Sis2p, Vhs3p, while the subunits of the CoA-synthesizing protein complex (CoA-SPC) are: Cab2p, Cab3p, Cab4p, and Cab5p as well as Sis2p and Vhs3p; null mutant lethality is complemented by E. coli coaBC" /db_xref="GeneID:853774" /db_xref="SGD:S000001571" ORIGIN 1 mtdekvnsdq nmngkqgvnl isslpttqvp vsiltnkerr ksihdesnfe rsdshedqsk 61 snsnrrniyk ndystnlrdf sfanlkqnse rnkdgheiqi ntsmpantng qqkrfspslp 121 savsftvpev erlpyhrysi snkpgkqqqq qeqlqqnqqq eeqqkaqlqe qnqrakqqee 181 vkqiqeqvqk kqterqqlid ekerianaif kenttndgtd irkhsvssgt snsedevdsp 241 smeknsivhm pgdfiyfnpk snaskpitak aaplsannst hknkevitap tgprvpftef 301 fqkeddkkfh iligatgsva tikvpliidk lfkiygpeki siqlivtkpa ehflkglkms 361 thvkiwreed awvfdavnkn dtslslnlil hhelrkwadi fliaplsant laklangicn 421 nlltsvmrdw spltpvliap amntfmyinp mtkkhltslv qdypfiqvlk pvekvlicgd 481 igmggmrewt diveivrrri neirkardee tgdkeqeqee qegadneddd deddeedeed 541 eeeeealnet asdesndeed eedeedvkte v // LOCUS NP_012836 224 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c1 heme lyase CYT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012836 VERSION NP_012836.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179653.1 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 224) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09071. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..224 /product="cytochrome c1 heme lyase CYT2" /EC_number="4.4.1.17" /calculated_mol_wt="25945" Region <57..218 /region_name="Cyto_heme_lyase" /note="Cytochrome c/c1 heme lyase; pfam01265" /db_xref="CDD:426167" CDS 1..224 /gene="CYT2" /locus_tag="YKL087C" /coded_by="NM_001179653.1:1..675" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:7559417]" /experiment="EXISTENCE:mutant phenotype:GO:0004408 holocytochrome-c synthase activity [PMID:1499554]" /experiment="EXISTENCE:mutant phenotype:GO:0018063 cytochrome c-heme linkage [PMID:1499554]" /note="Cytochrome c1 heme lyase; involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1; human homolog HCCS can complement yeast cyt2 null mutant" /db_xref="GeneID:853775" /db_xref="SGD:S000001570" ORIGIN 1 mmssdqqgkc pvdeetkklw lrehgneahp gatapgnqle csanpqdndk tpeyhttvdl 61 sqsrevstip rtnsdrnwiy psekqfyeam mkknwdpnsd dmkvvvplhn sinervwnyi 121 kswedkqgge acggikltnf kgdskkltpr awfrsrilhl akpfdrhdwq idrcgktvdy 181 vidfystdln dansqqqpli yldvrpklns fegfrlrfwk slgf // LOCUS NP_012837 127 aa linear PLN 30-JUN-2025 DEFINITION sulfiredoxin [Saccharomyces cerevisiae S288C]. ACCESSION NP_012837 VERSION NP_012837.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179652.1 REFERENCE 1 (residues 1 to 127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 127) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09072. Method: conceptual translation. FEATURES Location/Qualifiers source 1..127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..127 /product="sulfiredoxin" /EC_number="1.8.98.2" /calculated_mol_wt="13723" Region 11..121 /region_name="Srx" /note="Sulfiredoxin reactivates peroxiredoxins after oxidative inactivation; cd16395" /db_xref="CDD:319253" Site order(11..14,19..23,66,68..69,76..78,81..82,105,108..109, 114,117..118) /site_type="other" /note="peroxiredoxin binding site [polypeptide binding]" /db_xref="CDD:319253" Site order(30,33..34,37,61,63,82..86) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:319253" CDS 1..127 /gene="SRX1" /locus_tag="YKL086W" /coded_by="NM_001179652.1:1..384" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032542 sulfiredoxin activity [PMID:14586471]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:14586471]" /note="Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853776" /db_xref="SGD:S000001569" ORIGIN 1 mslqsnsvkp teiplseirr plapvldpqk idamvatmkg iptasktcsl eqaeaaasag 61 elppvdvlgv rvkgqtlyya fggchrlqay drraretqna afpvrcrvlp atprqirmyl 121 gssldie // LOCUS NP_012838 334 aa linear PLN 30-JUN-2025 DEFINITION malate dehydrogenase MDH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012838 VERSION NP_012838.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179651.1 REFERENCE 1 (residues 1 to 334) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 334) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 334) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 334) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09073. Method: conceptual translation. FEATURES Location/Qualifiers source 1..334 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..334 /product="malate dehydrogenase MDH1" /EC_number="1.1.1.37" /calculated_mol_wt="35519" Region 18..331 /region_name="MDH_glyoxysomal_mitochondrial" /note="Glyoxysomal and mitochondrial malate dehydrogenases; cd01337" /db_xref="CDD:133422" Site order(26..29,50,94,96..97,108,112,115,135,137,164,167,195, 241,245) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:133422" Site order(31,59..60,62..64,170..171,174,227,230,234..235, 241..244,247) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:133422" Site order(99,105,137,171,195,228) /site_type="other" /note="Substrate binding site [chemical binding]" /db_xref="CDD:133422" CDS 1..334 /gene="MDH1" /locus_tag="YKL085W" /coded_by="NM_001179651.1:1..1005" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:11502169|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:9774331]" /experiment="EXISTENCE:direct assay:GO:0030060 L-malate dehydrogenase (NAD+) activity [PMID:1898005]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:10777592]" /experiment="EXISTENCE:mutant phenotype:GO:0006099 tricarboxylic acid cycle [PMID:3312168]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:3312168]" /experiment="EXISTENCE:mutant phenotype:GO:0030060 L-malate dehydrogenase (NAD+) activity [PMID:10777592]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="Mitochondrial malate dehydrogenase; catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated; mutation in human homolog MDH2 causes early-onset severe encephalopathy" /db_xref="GeneID:853777" /db_xref="SGD:S000001568" ORIGIN 1 mlsrvakraf sstvanpykv tvlgagggig qplslllkln hkvtdlrlyd lkgakgvatd 61 lshiptnsvv kgftpeepdg lnnalkdtdm vlipagvprk pgmtrddlfa inasivrdla 121 aataesapna ailvisnpvn stvpivaqvl knkgvynpkk lfgvttldsi raarfiseve 181 ntdptqervn vigghsgiti iplisqtnhk lmsddkrhel ihriqfggde vvkakngags 241 atlsmahaga kfanavlsgf kgerdvieps fvdsplfkse gieffaspvt lgpdgiekih 301 pigelsseee emlqkcketl kkniekgvnf vask // LOCUS NP_012839 116 aa linear PLN 30-JUN-2025 DEFINITION Hot13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012839 VERSION NP_012839.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179650.1 REFERENCE 1 (residues 1 to 116) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 116) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 116) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 116) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09074. Method: conceptual translation. FEATURES Location/Qualifiers source 1..116 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..116 /product="Hot13p" /calculated_mol_wt="13510" Region 1..109 /region_name="COG4357" /note="Uncharacterized conserved protein, contains Zn-finger domain of CHY type [Function unknown]" /db_xref="CDD:443492" CDS 1..116 /gene="HOT13" /locus_tag="YKL084W" /coded_by="NM_001179650.1:1..351" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:15294910]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:18787558]" /experiment="EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:15294910]" /note="Zinc-binding mitochondrial intermembrane space (IMS) protein; involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc" /db_xref="GeneID:853778" /db_xref="SGD:S000001567" ORIGIN 1 mietaiygkt vddqsrcvhw hlpkdviair fkccdkyyac fechqelssh plekydlldd 61 ankhliicgv crhemtfaey ydynsnlicp ncrspfnpgc klhyhlyfqn pppamc // LOCUS NP_012841 434 aa linear PLN 30-JUN-2025 DEFINITION ribosome biosynthesis protein RRP14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012841 VERSION NP_012841.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179648.1 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 434) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09075. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..434 /product="ribosome biosynthesis protein RRP14" /calculated_mol_wt="50351" Region 8..58 /region_name="RRP14" /note="60S ribosome biogenesis protein Rrp14; pfam15459" /db_xref="CDD:464729" Region 221..400 /region_name="SURF6" /note="Surfeit locus protein 6; pfam04935" /db_xref="CDD:461491" CDS 1..434 /gene="RRP14" /locus_tag="YKL082C" /coded_by="NM_001179648.1:1..1305" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:17804645|PMID:11489916]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:17804645|PMID:17272295]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:17272295]" /note="Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family" /db_xref="GeneID:853780" /db_xref="SGD:S000001565" ORIGIN 1 msnsleerlr anssafdgll alipakyyyd eksqeqwkak kktkeqsknd klkkldpeqr 61 ddetsstlev mkkkekdakp vvlpgekfkh mkmqkqkeat skvegdsdln vevndpmiia 121 pdedeeeeed ikvifddegn eipleskkdt tepdrsvekk siteeeklqr kknlealrsk 181 lqakisdmks krkapgsrea ilaqrkrkee lkkrkrlese qeqdqdeias dsdmedidsd 241 lennskkrfk kgkkdseina dgvmfqniif ddgaratsdl qrlrkagrtk gpakndvksh 301 lklleakknk meakdeleqi kqkekekwqk amlqaegiki rddekllrka ikrkeaqkrk 361 saiewserkr vvedtiserq krreenlrir kdnkgkkrnk qekmkrkyvg savpkkragf 421 egrlktgkkk ggpk // LOCUS NP_012842 412 aa linear PLN 30-JUN-2025 DEFINITION translation elongation factor EF1B gamma [Saccharomyces cerevisiae S288C]. ACCESSION NP_012842 VERSION NP_012842.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179647.1 REFERENCE 1 (residues 1 to 412) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 412) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 412) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 412) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09076. Method: conceptual translation. FEATURES Location/Qualifiers source 1..412 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..412 /product="translation elongation factor EF1B gamma" /calculated_mol_wt="46389" Region 4..72 /region_name="GST_N_EF1Bgamma" /note="GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of...; cd03044" /db_xref="CDD:239342" Site order(12,15,18..19,22,63) /site_type="other" /note="C-terminal domain interface [polypeptide binding]" /db_xref="CDD:239342" Site order(13,47..49,61..62) /site_type="other" /note="putative GSH binding site (G-site) [chemical binding]" /db_xref="CDD:239342" Site order(47,60..61,63..64,67) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:239342" Region 89..211 /region_name="GST_C_EF1Bgamma_like" /note="Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins; cd03181" /db_xref="CDD:198290" Site order(94..95,98..99,102,139) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:198290" Site order(101,164,168,197,200..202) /site_type="other" /note="N-terminal domain interface [polypeptide binding]" /db_xref="CDD:198290" Region 253..356 /region_name="EF1G" /note="Elongation factor 1 gamma, conserved domain; pfam00647" /db_xref="CDD:459888" CDS 1..412 /gene="TEF4" /locus_tag="YKL081W" /gene_synonym="EFC1" /coded_by="NM_001179647.1:1..1239" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:3528160]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006414 translational elongation [PMID:3528160]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:23451152]" /note="Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex" /db_xref="GeneID:853781" /db_xref="SGD:S000001564" ORIGIN 1 msqgtlyinr sprnyaseal isyfkldvki vdleqssefa slfplkqapa flgpkglklt 61 ealaiqfyla nqvadekera rllgsdviek sqilrwasla nsdvmsniar pflsfkglip 121 ynkkdvdacf vkidnlaavf darlrdytfv atenislgdl haagswafgl atilgpewra 181 khphlmrwfn tvaaspivkt pfaevklaek altytppkkq kaekpkaeks kaekkkdeak 241 paddaapakk pkhplealgk stfvlddwkr kysnddtrpv alpwfwehyn peeysiwkvg 301 ykyndeltlt fmsnnlvggf fnrlsastky mfgclvvyge nnnngivgav mvrgqdfapa 361 fdvapdwesy eytkldptke edkefvnnmw awdkpvvvng edkeivdgkv lk // LOCUS NP_012843 392 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V1 sector ATPase subunit C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012843 VERSION NP_012843.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179646.1 REFERENCE 1 (residues 1 to 392) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 392) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 392) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 392) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09077. Method: conceptual translation. FEATURES Location/Qualifiers source 1..392 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..392 /product="H(+)-transporting V1 sector ATPase subunit C" /calculated_mol_wt="44058" Region 6..392 /region_name="COG5127" /note="Vacuolar H+-ATPase V1 sector, subunit C [Energy production and conversion]" /db_xref="CDD:227456" Region 66..86 /region_name="3-helical coiled coil" /note="3-helical coiled coil [structural motif]" /db_xref="CDD:270211" Region 130..156 /region_name="3-helical coiled coil" /note="3-helical coiled coil [structural motif]" /db_xref="CDD:270211" Region 284..315 /region_name="3-helical coiled coil" /note="3-helical coiled coil [structural motif]" /db_xref="CDD:270211" CDS 1..392 /gene="VMA5" /locus_tag="YKL080W" /gene_synonym="CSL5; VAT3" /coded_by="NM_001179646.1:1..1179" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /note="Subunit C of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane; the V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase) has eight subunits" /db_xref="GeneID:853782" /db_xref="SGD:S000001563" ORIGIN 1 matalytand filislpqna qpvtapgskt dswfnetlig grafvsdfki pefkigsldt 61 liveseelsk vdnqigasig kiieilqgln etstnayrtl pinnmpvpey lenfqwqtrk 121 fkldksikdl itlisnessq ldadvratya nynsaktnla aaerkktgdl svrslhdivk 181 pedfvlnseh lttvlvavpk slksdfeksy etlsknvvpa sasviaedae yvlfnvhlfk 241 knvqefttaa rekkfipref nyseelidql kkehdsaasl eqslrvqlvr laktayvdvf 301 inwfhikalr vyvesvlryg lpphfnikii avppknlskc kselidafgf lggnafmkdk 361 kgkinkqdts lhqyaslvdt eyepfvmyii nl // LOCUS NP_012844 656 aa linear PLN 30-JUN-2025 DEFINITION Smy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012844 VERSION NP_012844.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179645.1 REFERENCE 1 (residues 1 to 656) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 656) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 656) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 656) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09078. Method: conceptual translation. FEATURES Location/Qualifiers source 1..656 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..656 /product="Smy1p" /calculated_mol_wt="73668" Region 25..364 /region_name="KISc_KHC_KIF5" /note="Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup; cd01369" /db_xref="CDD:276820" Site order(35,114,117,119..122,262) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:276820" Site order(186..188,191,315,319..320) /site_type="other" /note="beta tubulin interaction site [polypeptide binding]" /db_xref="CDD:276820" Site order(187..189,191,268..270,279,283,287,315,320) /site_type="other" /note="microtubule interaction site [polypeptide binding]" /db_xref="CDD:276820" Site order(266,268..269,283,286..287,290) /site_type="other" /note="alpha tubulin interaction site [polypeptide binding]" /db_xref="CDD:276820" Region <402..568 /region_name="COG2433" /note="Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only]" /db_xref="CDD:441980" CDS 1..656 /gene="SMY1" /locus_tag="YKL079W" /coded_by="NM_001179645.1:1..1971" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:8188749]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:8188749|PMID:9472039]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:8188749]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807|PMID:8188749]" /experiment="EXISTENCE:genetic interaction:GO:0006904 vesicle docking involved in exocytosis [PMID:27307583]" /experiment="EXISTENCE:mutant phenotype:GO:0003774 cytoskeletal motor activity [PMID:9472039]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27307583]" /note="Kinesin-like myosin passenger-protein; interacts with Myo2p and enhances its interaction with Sec4p during transport of secretory vesicles; controls actin cable structure and dynamics" /db_xref="GeneID:853783" /db_xref="SGD:S000001562" ORIGIN 1 mhwniiskeq ssssvslptl dssepchiev ilraipekgl qnnestfkid pyentvlfrt 61 nnplhettke thstfqfdkv fdanatqedv qkflvhpiin dvlngyngtv itygpsfsgk 121 sysligskes egilpnickt lfdtleknee tkgdsfsvsv lafeiymekt ydllvplper 181 kplklhrsss kmdleikdic pahvgsyedl rsyiqavqnv gnrmacgdkt ersrshlvfq 241 lhveqrnrkd dilknsslyl vdlhgaekfd krtestlsqd alkklnqsie alkntvrsls 301 mkerdsaysa kgshssayre sqltevlkds lggnrktkvi ltcflsnvpt tlstlefgds 361 irqinnkvtd nttglnlkkk mdlfiqdmki kddnyvaqin ilkaeidslk slhnkslped 421 dekkmlentk keniklklql dsitqllsss tnedpnnrid eevseiltkr ceqiaqlels 481 fdrqmnsnsk lqqeleykks keealesmnv rlleqiqlqe reiqellttn ailkgeleth 541 tkltetrser ikslessvke lslnksaips prrgsmssss gntmlhieeg seisnspwsa 601 ntsskplvwg arkvssssia ttgsqesfva rpfkkglnlh sikvtsstpk spssgs // LOCUS NP_012845 735 aa linear PLN 30-JUN-2025 DEFINITION RNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012845 VERSION NP_012845.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179644.1 REFERENCE 1 (residues 1 to 735) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 735) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 735) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 735) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 735) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 735) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 735) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09079. Method: conceptual translation. FEATURES Location/Qualifiers source 1..735 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..735 /product="RNA helicase" /EC_number="3.6.4.13" /calculated_mol_wt="82583" Region 79..>534 /region_name="HrpA" /note="HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; COG1643" /db_xref="CDD:441249" Region 645..722 /region_name="OB_NTP_bind" /note="Oligonucleotide/oligosaccharide-binding (OB)-fold; pfam07717" /db_xref="CDD:400182" CDS 1..735 /gene="DHR2" /locus_tag="YKL078W" /coded_by="NM_001179644.1:1..2208" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:10982841]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10982841]" /experiment="EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:10982841]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16449634]" /note="Predominantly nucleolar DEAH-box ATP-dependent RNA helicase; required for 18S rRNA synthesis" /db_xref="GeneID:853784" /db_xref="SGD:S000001561" ORIGIN 1 maansnsrva snhtskkqkv rrnihpftnn trikraskiv kfndsgegdh vsdqrsnken 61 vltykslksr asdllkmret lpvyqhkrei msyiesnpvt vligetgsgk stqipqfvle 121 klydtkkhgs iavtqprrva ainlatrvaq ehgcklgeqv gysvrfdntt ttrtrlkylt 181 dgmllrelmm nsdlreysvi videahertv ltdlilgflk sliqgprpdl riivmsatlq 241 aekfseffnn apilfvegrk fdvkqyylka ptddivdavi rcciqinqge elgdilcflp 301 gqeeidkavt imekiakyvs deapvplivp yplyaalpav qqslvfapik gfkrkvvfst 361 niaetsvtis gvkfvvdsgl rkvkvwrhql glatlltvpi sqasamqrsg ragresegks 421 frlycesdyv klpkqsepei arsdvtspvl mlkrygvddl lnwtwfenpg keaivmglqe 481 lyelgaldtr gkitkrgqqm allplqphls svlikasevg clsqvidivs clsvenllln 541 pspeerdevn errlslcnag krygdlimlk elfdiyfyel gksqdasser ndwckglcis 601 irgfknvirv rdqlrvyckr lfssiseede eskkigedge liskilkcfl tgfikntaig 661 mpdrsyrtvs tgepisihps smlfmnkscp gimyteyvft tkgyarnvsr ielswlqevv 721 tnaaavakqk vsdsk // LOCUS NP_012846 392 aa linear PLN 30-JUN-2025 DEFINITION Psg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012846 VERSION NP_012846.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179643.1 REFERENCE 1 (residues 1 to 392) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 392) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 392) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 392) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09080. Method: conceptual translation. FEATURES Location/Qualifiers source 1..392 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..392 /product="Psg1p" /calculated_mol_wt="45905" Region 143..325 /region_name="Psg1" /note="Ykl077w/Psg1 (Pma1 Stabilization in Golgi); pfam14610" /db_xref="CDD:464218" CDS 1..392 /gene="PSG1" /locus_tag="YKL077W" /coded_by="NM_001179643.1:1..1179" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:28727280]" /experiment="EXISTENCE:mutant phenotype:GO:0006605 protein targeting [PMID:28727280]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:28727280]" /note="Protein that promotes the transport and maturation of Pma1 with Exp1; cleaved specifically by Kex2p; localizes to the Golgi apparatus and to the endoplasmic reticulum in HTP studies" /db_xref="GeneID:853785" /db_xref="SGD:S000001560" ORIGIN 1 mrfhdsilif fslaslyqhv hgarqvvrpk ekmttseevk pwlrtvygsq kelvtptvia 61 gvtfsekpee tpnplkpwvs lehdgrpkti kpeinkgrtk kgrpdystyf ktvsshtysy 121 eelkahnmgp nevfveeeyi deddtyvsln pivrctpnly fnkglakdir sepfctpyen 181 srwkvdktyf vtwytrfftd ensgkvadkv rvhlsyvken pvekgnykrd ipatffssew 241 idndnglmpv evrdewlqdq fdrrivvsvq piyisdedfd plqygillyi tkgskvfkpt 301 keqlalddag itndqwyyva lsiptvvvvf fvfmyfflyv ngknrdftdv trkalnkkrr 361 vlgkfsemkk fknmknhkyt elpsykktsk qn // LOCUS NP_012848 450 aa linear PLN 30-JUN-2025 DEFINITION Aan1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012848 VERSION NP_012848.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179641.1 REFERENCE 1 (residues 1 to 450) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 450) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 450) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 450) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09081. Method: conceptual translation. FEATURES Location/Qualifiers source 1..450 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..450 /product="Aan1p" /calculated_mol_wt="51957" CDS 1..450 /gene="AAN1" /locus_tag="YKL075C" /coded_by="NM_001179641.1:1..1353" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:35577788]" /experiment="EXISTENCE:mutant phenotype:GO:0009081 branched-chain amino acid metabolic process [PMID:35577788]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:16121259]" /note="hypothetical protein; regulates actin cable stability and branched-chain amino acid (BCAA) metabolism; involved in mitochondrial quality control and longevity; proposed to be involved in resistance to streptozotocin and camptothecin; localizes to punctate cytosolic structures" /db_xref="GeneID:853787" /db_xref="SGD:S000001558" ORIGIN 1 makdllpkqa anepslkdct ckrclklgas kekkirrkkk geekrerhyg nrrkltfnfl 61 khtnmentny dvitsvgyln ekyglkkshy iekfikcihr kinidvskit dayvnslnpw 121 vkvklflllv tlsekggpey wldktdgekn seasstdnsl enstkgadsa gstalrdemv 181 kshknlfptl teqiiqhnin qdftestyde dyvfssiwan fmeglinhyl ekvivpysem 241 kvcqqlykpm mkiislyney nelmvksekn gflpslqdse nvqgdkgeke skddavsqer 301 leraqkllwq aredipktis keltllsemy stlsadeqdy eldefvccae eyieleylpa 361 lvdvlfancg tnnfwkimlv lepffyyied vggdddeded nvdnsegdee sllsrnvegd 421 dnvverhfkp dprvitleki cevaarqkwi // LOCUS NP_012849 527 aa linear PLN 30-JUN-2025 DEFINITION Mud2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012849 VERSION NP_012849.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179640.1 REFERENCE 1 (residues 1 to 527) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 527) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 527) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 527) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 527) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09082. Method: conceptual translation. FEATURES Location/Qualifiers source 1..527 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..527 /product="Mud2p" /calculated_mol_wt="60329" Region <46..>156 /region_name="PRK12678" /note="transcription termination factor Rho; Provisional" /db_xref="CDD:237171" Region 436..511 /region_name="RRM_1" /note="RNA recognition motif; smart00361" /db_xref="CDD:214637" Site order(439..440,442..444,446..448,450..451,498,500..504,508) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:409679" CDS 1..527 /gene="MUD2" /locus_tag="YKL074C" /coded_by="NM_001179640.1:1..1584" /experiment="EXISTENCE:direct assay:GO:0000243 commitment complex [PMID:7926772]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0045131 pre-mRNA branch point binding [PMID:7926772]" /experiment="EXISTENCE:genetic interaction:GO:0000348 mRNA branch site recognition [PMID:18375978]" /experiment="EXISTENCE:mutant phenotype:GO:0000243 commitment complex [PMID:7926772]" /experiment="EXISTENCE:mutant phenotype:GO:0000348 mRNA branch site recognition [PMID:9130720]" /note="Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65" /db_xref="GeneID:853788" /db_xref="SGD:S000001557" ORIGIN 1 madekrledl rskimesigk sekdvvpien krfntdnavi dthfkrqksd gelpkapksr 61 nvshsnnrgp ssiitmstnr ttyeqtragp hrqsyrdasg rsynrenrys shntgpqwnn 121 npynrqrder rgrnerfdrr grngngnydr fnyqrknegs kfngdrdkrq lqtnkydmny 181 nsqnvmypgs sfdspayynm asskansrlv isglsqssdp sivarlkdll enfisglqkt 241 esnaedfkis nfyigegrpd hiivefssqi cstmvlacrs ffnaklgtfd lkwrrpndyv 301 qqldhlvdfc rgtvialenl enigegedyr mkelfsslnv tngtakplfy kcssntnntg 361 keseftkcil lsfevvtqdi ldklkpykwf kpndgkisqv tswitfqslp nlvtqsvrve 421 srvllllncl dpldlkdetf iteiketlky siagadtiki cqpgvdyrln fenlasgagn 481 iyikfktlea akhameelpg tqfndrtvlc tyideddfdm meatqls // LOCUS NP_012850 881 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family chaperone LHS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012850 VERSION NP_012850.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179639.1 REFERENCE 1 (residues 1 to 881) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 881) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 881) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 881) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09083. Method: conceptual translation. FEATURES Location/Qualifiers source 1..881 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..881 /product="Hsp70 family chaperone LHS1" /calculated_mol_wt="99441" Region 21..431 /region_name="ASKHA_NBD_HSP70_HYOU1" /note="nucleotide-binding domain (NBD) of hypoxia up-regulated protein 1 (HYOU1) and similar proteins; cd10230" /db_xref="CDD:466828" CDS 1..881 /gene="LHS1" /locus_tag="YKL073W" /gene_synonym="CER1; SSI1" /coded_by="NM_001179639.1:1..2646" /experiment="EXISTENCE:direct assay:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:14704430]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:19759005]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:8887673|PMID:8654361]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:19759005]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:8654361|PMID:8887673]" /experiment="EXISTENCE:mutant phenotype:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:8887673|PMID:8654361]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:10409721|PMID:8887673|PMID:8654361]" /note="Molecular chaperone of the endoplasmic reticulum lumen; involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway" /db_xref="GeneID:853789" /db_xref="SGD:S000001556" ORIGIN 1 mrnvlrllfl tafvaigsla avlgvdygqq nikaivvspq aplelvltpe akrkeisgls 61 ikrlpgygkd dpngieriyg savgslatrf pqntllhlkp llgksledet tvtlyskqhp 121 glemvstnrs tiaflvdnve ypleelvamn vqeianrans llkdrdarte dfvnkmsfti 181 pdffdqhqrk alldassitt gieetylvse gmsvavnfvl kqrqfppgeq qhyivydmgs 241 gsikasmfsi lqpedttqpv tiefegygyn phlggakftm digslienkf lethpairtd 301 elhanpkala kinqaaekak lilsanseas inieslindi dfrtsitrqe feefiadsll 361 divkpindav tkqfggygtn lpeingvila ggssripivq dqliklvsee kvlrnvnade 421 savngvvmrg iklsnsfktk plnvvdrsvn tysfklsnes elydvftrgs aypnktsilt 481 nttdsipnnf tidlfengkl fetitvnsga iknsyssdkc ssgvaynitf dlssdrlfsi 541 qevncicqse ndignskqik nkgsrlafts edveikrlsp sersrlhehi klldkqdker 601 fqfqenlnvl esnlydarnl lmddevmqng pksqveelse mvkvyldwle dasfdtdped 661 ivsrireigi lkkkielymd sakeplnsqq fkgmleeghk llqaiethkn tveeflsqfe 721 tefadtidnv reefkkikqp ayvskalstw eetltsfkns iseiekflak nlfgedlreh 781 lfeiklqfdm yrtkleeklr liksgdesrl neikklhlrn frlqkrkeek lkrkleqeks 841 rnnnetestv insaddktti vndkttesnp sseedilhde l // LOCUS NP_012851 766 aa linear PLN 30-JUN-2025 DEFINITION Stb6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012851 VERSION NP_012851.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179638.1 REFERENCE 1 (residues 1 to 766) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 766) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 766) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 766) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09084. Method: conceptual translation. FEATURES Location/Qualifiers source 1..766 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..766 /product="Stb6p" /calculated_mol_wt="88705" Region 601..>687 /region_name="Sds3" /note="Sds3-like; pfam08598" /db_xref="CDD:430099" CDS 1..766 /gene="STB6" /locus_tag="YKL072W" /coded_by="NM_001179638.1:1..2301" /note="Protein that binds Sin3p in a two-hybrid assay; STB6 has a paralog, STB2, that arose from the whole genome duplication" /db_xref="GeneID:853790" /db_xref="SGD:S000001555" ORIGIN 1 mqleathqke nhlsplasfi fpdfralfni gfnlysniny kevdingfei yiveqwaaqr 61 kistlitsyt gnlqdtisav evalpedpee wpcclkkyhe ellkfsspkk takgtlfvtn 121 lssfkstlnl lhvecgnlkk iwknfktnyd lkrlhcggrs aqllkktpsa siakfaqlyk 181 fpnsafshei tsdfqqpslq ndnssissie nipvnhcpvv elttlvqisl syfalfeykk 241 erdgllcngt kqslekwwei ygkryhgidk pknetilgpt tvasllslvl tcyfklmved 301 cmsakdpfde eefysglyaf qkkyglsknn kqtsldelti dklfevsskt snkdifkfkk 361 vvkstvqdmt gkgnfmhlsn eilttdldtl vknihggslg klwkgrsasr ketcmvwerk 421 tflsfkferg dpslqlenne lfygtsvpse qlttsnkeds dtqptkrnsi ydiangskss 481 lsissmfcny detrykstnn lnrayrgeyf rrnsipfcnd gihdtkkisa dlnkidglyr 541 cnsysevqna ielwslpfds svirlardll kiqslmsvqr qldeirdgyl gknsqrsyqn 601 dlmfrqslnk lqemcerckr gsnefhweyg nmqnkqqile sekkdmksls sklkynvril 661 drrvrdveas vdhfdrkled vrkklleqnn skdismales pcdkfefdsf mdsivqsqqt 721 kyeglcfkil dkkslrklkk efwkwstwtf dtflyknrpn kekdtl // LOCUS NP_012852 256 aa linear PLN 30-JUN-2025 DEFINITION Osi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012852 VERSION NP_012852.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179637.1 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 256) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09085. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..256 /product="Osi1p" /calculated_mol_wt="27908" Region 9..253 /region_name="carb_red_sniffer_like_SDR_c" /note="carbonyl reductase sniffer-like, classical (c) SDRs; cd05325" /db_xref="CDD:187586" Site order(13,15..18,39,66..67,95..98,119,146..148,164,168, 193..197,199,201..202) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:187586" Site order(67,77,113,118,121..123,126,129..130,150..156,162, 165..166,169..170,173..174,176..177,180..181) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:187586" Site order(120,148,164,168) /site_type="active" /db_xref="CDD:187586" CDS 1..256 /gene="OSI1" /locus_tag="YKL071W" /coded_by="NM_001179637.1:1..771" /experiment="EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:29034432]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0110095 cellular detoxification of aldehyde [PMID:19854918]" /note="NADH-dependent short-chain aldehyde reductase; involved in detoxification of furfural; expression is upregulated in cells treated with the aldehydes furfural and glycolaldehyde, the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:853792" /db_xref="SGD:S000001554" ORIGIN 1 mntssrityf iiggsrgigf nlvkilsast gntvitsirg spslpknkqv edlakirkni 61 hivqldltkd esigniadei kktpfflgid ifiacsavsd syykvletpk svwlnhystn 121 algpilalqk vypllllkkt rkiffissva gsinafvpls vsaygqskaa lnyavktlsf 181 elkpegftvv afhpgmvstd mgqygldhfk eknidisgvn iitpeesasa lidvfrkilp 241 edngkffnyd gsegvf // LOCUS NP_012853 169 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKL070W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012853 VERSION NP_012853.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179636.1 REFERENCE 1 (residues 1 to 169) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 169) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 169) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 169) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09086. Method: conceptual translation. FEATURES Location/Qualifiers source 1..169 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..169 /product="uncharacterized protein" /calculated_mol_wt="19697" Region 2..158 /region_name="FMN_bind_2" /note="Putative FMN-binding domain; pfam04299" /db_xref="CDD:461254" CDS 1..169 /locus_tag="YKL070W" /coded_by="NM_001179636.1:1..510" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="hypothetical protein; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:853793" /db_xref="SGD:S000001553" ORIGIN 1 myipkhfesm elsryklskk pplgtlfssk asrqgffgwr tssnkddpdf gmcashipfv 61 fvefdngehk liahlarknk hvemlervqk clvvfqsvds yispawfpmk kkthkfvptw 121 dfaavhvygt priirddkdw linmlstltd qeeekrpege nvrskverf // LOCUS NP_012854 180 aa linear PLN 30-JUN-2025 DEFINITION L-methionine (R)-S-oxide reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012854 VERSION NP_012854.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179635.1 REFERENCE 1 (residues 1 to 180) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 180) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 180) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 180) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09087. Method: conceptual translation. FEATURES Location/Qualifiers source 1..180 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..180 /product="L-methionine (R)-S-oxide reductase" /EC_number="1.8.4.14" /calculated_mol_wt="19603" Region 17..173 /region_name="MsrC" /note="GAF domain-containing protein, putative methionine-R-sulfoxide reductase [Defense mechanisms, Signal transduction mechanisms]; COG1956" /db_xref="CDD:441559" CDS 1..180 /locus_tag="YKL069W" /gene_synonym="YKG9" /coded_by="NM_001179635.1:1..543" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0033745 L-methionine-(R)-S-oxide reductase activity [PMID:19049972]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:19049972]" /note="Methionine-R-sulfoxide reductase; reduces the R enantiomer of free Met-SO, in contrast to Mxr2p which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress; binds and degrades patulin, a polyketide mycotoxin, forming E-ascladiol; strong substrate specificity towards patulin but not other mycotoxins; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:853794" /db_xref="SGD:S000001552" ORIGIN 1 mgsstgfhha dhvnyssnln keeileqlll syeglsdgqv nwvcnlsnas sliwhayksl 61 avdinwagfy vtqaseentl ilgpfqgkva cqmiqfgkgv cgtaastket qivpdvnkyp 121 ghiacdgetk seivvpiisn dgktlgvidi dcldyegfdh vdkeflekla klinkscvfk // LOCUS NP_878111 78 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKL068W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878111 VERSION NP_878111.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184534.1 REFERENCE 1 (residues 1 to 78) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 78) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 78) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 78) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09088. Method: conceptual translation. FEATURES Location/Qualifiers source 1..78 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..78 /product="uncharacterized protein" /calculated_mol_wt="8727" CDS 1..78 /locus_tag="YKL068W-A" /coded_by="NM_001184534.1:1..237" /note="hypothetical protein; identified by homology to Ashbya gossypii" /db_xref="GeneID:1500487" /db_xref="SGD:S000028524" ORIGIN 1 mqanhsvsyl yesstskrsn glfsqtqkqg sfqkalsqtq eeiededlmv dlntgsltpv 61 klkywtqmsa mtekfgkl // LOCUS NP_012855 959 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin NUP100 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012855 VERSION NP_012855.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179634.1 REFERENCE 1 (residues 1 to 959) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 959) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 959) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 959) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 959) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 959) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 959) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09089. Method: conceptual translation. FEATURES Location/Qualifiers source 1..959 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..959 /product="FG-nucleoporin NUP100" /calculated_mol_wt="99857" Region <54..647 /region_name="FhaB" /note="Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]; COG3210" /db_xref="CDD:442443" Region 814..955 /region_name="Nucleoporin2" /note="Nucleoporin autopeptidase; pfam04096" /db_xref="CDD:461171" CDS 1..959 /gene="NUP100" /locus_tag="YKL068W" /gene_synonym="NSP100" /coded_by="NM_001179634.1:1..2880" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:8195299]" /experiment="EXISTENCE:direct assay:GO:0017056 structural constituent of nuclear pore [PMID:19098896]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]" /experiment="EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:20647373]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:20647373]" /experiment="EXISTENCE:genetic interaction:GO:0036228 protein localization to nuclear inner membrane [PMID:21659568]" /experiment="EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:17418788]" /experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]" /experiment="EXISTENCE:mutant phenotype:GO:2000238 regulation of tRNA export from nucleus [PMID:27932586]" /experiment="EXISTENCE:physical interaction:GO:0006406 mRNA export from nucleus [PMID:11104765]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17803941|PMID:17418788|PMID:19098896|PMID:12917401]" /note="FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; NUP100 has a paralog, NUP116, that arose from the whole genome duplication" /db_xref="GeneID:853796" /db_xref="SGD:S000001551" ORIGIN 1 mfgnnrpmfg gsnlsfgsnt ssfggqqsqq pnslfgnsnn nnnstsnnaq sgfggftsaa 61 gsnsnslfgn nntqnngafg qsmgatqnsp fgslnssnas ngntfggsss mgsfggntnn 121 afnnnsnstn spfgfnkpnt ggtlfgsqnn nsagtsslfg gqststtgtf gntgssfgtg 181 lngngsnifg agnnsqsntt gslfgnqqss afgtnnqqgs lfgqqsqntn nafgnqnqlg 241 gssfgskpvg sgslfgqsnn tlgnttnnrn glfgqmnssn qgssnsglfg qnsmnsstqg 301 vfgqnnnqmq ingnnnnslf gkantfsnsa sgglfgqnnq qqgsglfgqn sqtsgssglf 361 gqnnqkqpnt ftqsntgigl fgqnnnqqqq stglfgakpa gttgslfggn sstqpnslfg 421 ttnvptsntq sqqgnslfga tkltnmpfgg nptanqsgsg nslfgtkpas ttgslfgnnt 481 asttvpstng lfgnnannst sttntglfga kpdsqskpal ggglfgnsns nsstigqnkp 541 vfggttqntg lfgatgtnss avgstgklfg qnnntlnvgt qnvppvnntt qnallgttav 601 pslqqapvtn eqlfskisip nsitnpvkat tskvnadmkr nssltsayrl apkplfapss 661 ngdakfqkwg ktlersdrgs stsnsitdpe ssylnsndll fdpdrrylkh lviknnknln 721 vinhnddeas kvklvtftte saskddqass siaaskltek ahspqtdlkd dhdestpdpq 781 skspngstsi pmienekiss kvpgllsndv tffknnyyis psietlgnks lielrkinnl 841 vighrnygkv eflepvdlln tpldtlcgdl vtfgpkscsi yencsikpek geginvrcrv 901 tlyscfpidk etrkpiknit hpllkrsiak lkenpvykfe sydpvtgtys ytidhpvlt // LOCUS NP_012856 153 aa linear PLN 30-JUN-2025 DEFINITION nucleoside diphosphate kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012856 VERSION NP_012856.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179633.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 153) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09090. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..153 /product="nucleoside diphosphate kinase" /EC_number="2.7.4.6" /calculated_mol_wt="17036" Region 4..152 /region_name="NDPk" /note="Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; cl00335" /db_xref="CDD:469726" Site order(13,53,61,89,95,106,116,119,121..122,130) /site_type="active" /db_xref="CDD:239876" Site order(17,22..24,27,30,39..41) /site_type="other" /note="multimer interface [polypeptide binding]" /db_xref="CDD:239876" CDS 1..153 /gene="YNK1" /locus_tag="YKL067W" /gene_synonym="NDK1" /coded_by="NM_001179633.1:1..462" /experiment="EXISTENCE:direct assay:GO:0004550 nucleoside diphosphate kinase activity [PMID:12472466]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:12472466]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12472466]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:18983998]" /note="Nucleoside diphosphate kinase; catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853798" /db_xref="SGD:S000001550" ORIGIN 1 mssqtertfi avkpdgvqrg lvsqilsrfe kkgyklvaik lvkaddklle qhyaehvgkp 61 ffpkmvsfmk sgpilatvwe gkdvvrqgrt ilgatnplgs apgtirgdfg idlgrnvchg 121 sdsvdsaere inlwfkkeel vdwesnqakw iye // LOCUS NP_001032580 73 aa linear PLN 30-JUN-2025 DEFINITION Dpc7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032580 VERSION NP_001032580.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184684.1 REFERENCE 1 (residues 1 to 73) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 73) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 73) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 73) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09091. Method: conceptual translation. FEATURES Location/Qualifiers source 1..73 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..73 /product="Dpc7p" /calculated_mol_wt="8400" CDS 1..73 /gene="DPC7" /locus_tag="YKL065W-A" /coded_by="NM_001184684.1:1..222" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; SWAT-GFP fusion protein localizes to endoplasmic reticulum (ER) while mCherry fusion localizes to both ER and vacuole" /db_xref="GeneID:3799975" /db_xref="SGD:S000113563" ORIGIN 1 mrsnilkllq rtsrryvssk dfepvigsnp kkqtsrlmvg svgvmipvll ylfykndskh 61 seikkiyqne kki // LOCUS NP_012858 206 aa linear PLN 30-JUN-2025 DEFINITION Yet1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012858 VERSION NP_012858.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179631.2 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 206) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09092. On Apr 26, 2011 this sequence version replaced NP_012858.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..206 /product="Yet1p" /calculated_mol_wt="23328" Region 14..206 /region_name="COG5374" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227666" CDS 1..206 /gene="YET1" /locus_tag="YKL065C" /coded_by="NM_001179631.2:1..621" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20378542|PMID:26928762|PMID:14562095]" /note="Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein; YET1 has a paralog, YET2, that arose from the whole genome duplication" /db_xref="GeneID:853800" /db_xref="SGD:S000001548" ORIGIN 1 mslyfttlfl lltvemvmlf ifvlplpfri rrgifstynq ltakqqikti ifitgclvgl 61 lfidswkrsq irvslyhndn sgsigssavt piqalasray nqrnmyisgf ilyfsicipt 121 vmsivkrlvk yqglineqek qklnkpssns kkdsneadst klqeelrkkq isleglqkqv 181 knlekyfdek nqpgnvaaae askkgn // LOCUS NP_012859 969 aa linear PLN 30-JUN-2025 DEFINITION putative Mg(2+) transporter MNR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012859 VERSION NP_012859.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179630.1 REFERENCE 1 (residues 1 to 969) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 969) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 969) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 969) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 969) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 969) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 969) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09093. Method: conceptual translation. FEATURES Location/Qualifiers source 1..969 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..969 /product="putative Mg(2+) transporter MNR2" /calculated_mol_wt="109606" Region 500..965 /region_name="Alr1p-like" /note="Saccharomyces cerevisiae Alr1p-like subfamily; cd12829" /db_xref="CDD:213363" Site order(523,526..527,536,538,692,696,710,713,721,724,728, 734..735,738,814..815,818,821..822,825,829,859..860, 862..863,866..867,869..870,873..874,876..877,879..881, 891..898,900..912,914..916,918..923,925..932,942..943,948, 960,963) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:213363" Site order(696,710) /site_type="other" /note="putative Cl binding site [ion binding]" /db_xref="CDD:213363" Site order(908,911) /site_type="other" /note="hydrophobic gate" /db_xref="CDD:213363" Site order(926,928..929) /site_type="other" /note="periplasmic entrance" /db_xref="CDD:213363" CDS 1..969 /gene="MNR2" /locus_tag="YKL064W" /coded_by="NM_001179630.1:1..2910" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:19001347|PMID:19720860]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:mutant phenotype:GO:0010961 intracellular magnesium ion homeostasis [PMID:19720860]" /experiment="EXISTENCE:mutant phenotype:GO:0015095 magnesium ion transmembrane transporter activity [PMID:19720860]" /note="Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)" /db_xref="GeneID:853801" /db_xref="SGD:S000001547" ORIGIN 1 mstdnsqkde gvpllspyss spqlrkkkrn qkrrkdkfvg hlksdsrrpt qllhdnlqhn 61 hgqitdfdqi dswgmlhesd stsndiikse dpslkgafid hrpsmsqpre gpqsvsstvq 121 pqpimkfstp sykkpaglrp sdqnrslvsd lspseleswl krrksvhksf vdensptdrr 181 qsnanndvvi dvdalmnhvn nnastgvndn skrrkkkrgs ddssnknsks tssdsndeed 241 eynsrpsssl ssnnsslddv clvlddegse vpkawpdctv leefskeete rlrsqaiqda 301 eafhfqyded eedgtsnedg ilfskpivtn idvpelgnrr vnetenlkng rlrpkriapw 361 hliqrpmvlg snstkdsksr iqsglqdnll vgrniqypph iisnnpehfr ftyfrvdlds 421 tvhsptisgl lqpgqkfqdl fvasiysqdn saghikthpn sptpgikaet vsqlqgltak 481 npstlssmsv aniedvppfw ldvsnpteee mkilskafgi hplttedifl gevrekvelf 541 rdyylicfrs fdivaekhvr rrrkekqesa tldhesisrr ksqaygatms nesnannnns 601 tsnasrskwl psilrarrrs sanrttntss ssykrrvkse kkkmeenekf krksgdrhkp 661 regeleplnv yiivfrtgvl tfhfaptphp invrrrarll kdylnvtsdw iayaliddit 721 dafapmieli edevyeieda ilkmhqsdds sdsdssdsds dsgasdedaf pfdvyskkts 781 yssakssvss rsmstseasf nanligwkrk gdmlrrigec rkrvmsilrl lgskadvikg 841 fakryneqwe aspqseiamy lgdiqdhivt mvsslnhyek llsrshsnyl aqinidmtkv 901 nndmndvlgk itilgtivlp mnvitglwgm nvivpgqyrd sltwfigivl fmcmlacsay 961 mytkrrfgf // LOCUS NP_012860 167 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKL063C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012860 VERSION NP_012860.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179629.1 REFERENCE 1 (residues 1 to 167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 167) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09094. Method: conceptual translation. FEATURES Location/Qualifiers source 1..167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..167 /product="uncharacterized protein" /calculated_mol_wt="18872" CDS 1..167 /locus_tag="YKL063C" /coded_by="NM_001179629.1:1..504" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the Golgi" /db_xref="GeneID:853802" /db_xref="SGD:S000001546" ORIGIN 1 mqgdirrkkd llpryktgsk ynsrrrggyl ttpmkkiivy iillcgvyfv ikvaysdlnk 61 eteikleshs sdvsasasdh tniaaggaad atnnkqpqqa kvpkekfnne vakqqevknl 121 endlkpqids ekqkqinkdk keqkqqlqke kqdlakenla nneildn // LOCUS NP_012861 630 aa linear PLN 30-JUN-2025 DEFINITION stress-responsive transcriptional activator MSN4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012861 VERSION NP_012861.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179628.1 REFERENCE 1 (residues 1 to 630) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 630) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 630) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 630) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 630) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09095. Method: conceptual translation. FEATURES Location/Qualifiers source 1..630 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..630 /product="stress-responsive transcriptional activator MSN4" /calculated_mol_wt="69592" Region 57..622 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 575..596 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 604..624 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..630 /gene="MSN4" /locus_tag="YKL062W" /coded_by="NM_001179628.1:1..1893" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:23435728|PMID:27637775]" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:8321194|PMID:8641288]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9472026|PMID:12732613]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12732613|PMID:9472026]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:18070923]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:26947009]" /experiment="EXISTENCE:genetic interaction:GO:0034198 cellular response to amino acid starvation [PMID:17914901]" /experiment="EXISTENCE:genetic interaction:GO:0034224 cellular response to zinc ion starvation [PMID:19702872]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:11102521|PMID:8641288|PMID:20398213|PMID:10652100]" /experiment="EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:26947009|PMID:8641288]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17914901|PMID:8641288|PMID:11102521|PMID:20398213|PM ID:15922872|PMID:21749328|PMID:27637775|PMID:26947009|PMID :10652100|PMID:17150183|PMID:19702872|PMID:19073887|PMID:1 7055490|PMID:16710843|PMID:15053871|PMID:11179418|PMID:154 83057]" /experiment="EXISTENCE:genetic interaction:GO:0070301 cellular response to hydrogen peroxide [PMID:8641288|PMID:11102521|PMID:10652100]" /experiment="EXISTENCE:genetic interaction:GO:0070417 cellular response to cold [PMID:15053871|PMID:15483057]" /experiment="EXISTENCE:genetic interaction:GO:0071243 cellular response to arsenic-containing substance [PMID:19073887|PMID:10652100]" /experiment="EXISTENCE:genetic interaction:GO:0071361 cellular response to ethanol [PMID:8641288]" /experiment="EXISTENCE:genetic interaction:GO:0071464 cellular response to hydrostatic pressure [PMID:17055490]" /experiment="EXISTENCE:genetic interaction:GO:0071469 cellular response to alkaline pH [PMID:21749328]" /experiment="EXISTENCE:genetic interaction:GO:0071476 cellular hypotonic response [PMID:8641288|PMID:17914901]" /experiment="EXISTENCE:genetic interaction:GO:0071497 cellular response to freezing [PMID:17150183]" /experiment="EXISTENCE:genetic interaction:GO:0071500 cellular response to nitrosative stress [PMID:16710843]" /experiment="EXISTENCE:genetic interaction:GO:1902075 cellular response to salt [PMID:17914901|PMID:8641288|PMID:10652100]" /experiment="EXISTENCE:genetic interaction:GO:1990451 cellular stress response to acidic pH [PMID:15922872|PMID:8641288|PMID:11179418]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8650168|PMID:27637775]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:11102521]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11102521|PMID:15922872]" /experiment="EXISTENCE:mutant phenotype:GO:0070301 cellular response to hydrogen peroxide [PMID:11102521]" /experiment="EXISTENCE:mutant phenotype:GO:1990451 cellular stress response to acidic pH [PMID:15922872]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27637775]" /note="Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift" /db_xref="GeneID:853803" /db_xref="SGD:S000001545" ORIGIN 1 mlvfgpnssf vrhankkqed ssimnepngl mdpvlsttnv satssndnsa nnsisspeyt 61 fgqfsmdsph rtdatntpil tattnttann slmnlkdtas latnwkwkns nnaqfvndge 121 kqssnangkk nggdkiyssv atpqalndel knleqlekvf spmnpindsh fnenielsph 181 qhatspktnl leaepsiysn lfldarlpnn ansttglndn dynlddtnnd ntnsmqsile 241 dfvsseealk fmpdagrdar rysevvtssf psmtdsrnsi shsiefwnln hknssnskpt 301 qqiipegtat terrgstisp tttinnsnpn fklldhdvsq alsgysmdfs kdsgitkpks 361 issslnrish sssttrqqra slplihdies fandsvmanp lsdsasflse eneddafgal 421 nynsldattm safdnnvdpf nilksspaqd qqfikpsmml sdnasaaakl atsgvdnitp 481 tpafqrrsyd ismnssfkil ptsqahhaaq hhqqqptkqa tvspntrrrk sssvtlspti 541 shnnnngkvp vqprkrksit tidpnnydkn kpfkckdcek afrrsehlkr hirsvhster 601 pfacmfcekk fsrsdnlsqh lkthkkhgdf // LOCUS NP_012862 113 aa linear PLN 30-JUN-2025 DEFINITION Bli1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012862 VERSION NP_012862.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179627.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 113) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09096. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..113 /product="Bli1p" /calculated_mol_wt="13390" Region 2..110 /region_name="BLI1" /note="BLOC-1 interactor 1; pfam17324" /db_xref="CDD:340040" CDS 1..113 /gene="BLI1" /locus_tag="YKL061W" /coded_by="NM_001179627.1:1..342" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]" /note="Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to the endosome" /db_xref="GeneID:853804" /db_xref="SGD:S000001544" ORIGIN 1 mgeqnklyyd veklvnslqe sfdldcaqsv slftsksrsn eawleelenk fklkddveld 61 dvenlraeid mklnmledkv syyerlykel eefqneikik tvvnnrrqsr tpk // LOCUS NP_012863 359 aa linear PLN 30-JUN-2025 DEFINITION fructose-bisphosphate aldolase FBA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012863 VERSION NP_012863.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179626.1 REFERENCE 1 (residues 1 to 359) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 359) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 359) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 359) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09097. Method: conceptual translation. FEATURES Location/Qualifiers source 1..359 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..359 /product="fructose-bisphosphate aldolase FBA1" /EC_number="4.1.2.13" /calculated_mol_wt="39490" Region 3..359 /region_name="FruBisAldo_II_A" /note="fructose-bisphosphate aldolase, class II, yeast/E. coli subtype; TIGR01520" /db_xref="CDD:130583" Site order(37,110..111,145,175,177,180..183,226..228,230, 265..266,268,287,289..290) /site_type="active" /db_xref="CDD:238476" Site order(40..42,45,66,69..71,89,93,96..97,183,290..291, 293..294,297,301,304) /site_type="other" /note="intersubunit interface [polypeptide binding]" /db_xref="CDD:238476" Site order(111,145,175,182,227,265) /site_type="other" /note="zinc binding site [ion binding]" /db_xref="CDD:238476" Site order(226,228,230,266,268) /site_type="other" /note="Na+ binding site [ion binding]" /db_xref="CDD:238476" CDS 1..359 /gene="FBA1" /locus_tag="YKL060C" /gene_synonym="LOT1" /coded_by="NM_001179626.1:1..1080" /experiment="EXISTENCE:direct assay:GO:0004332 fructose-bisphosphate aldolase activity [PMID:2647491]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16962558|PMID:16806052]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16806052]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:mutant phenotype:GO:0004332 fructose-bisphosphate aldolase activity [PMID:2647491]" /experiment="EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:6384192]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:6384192]" /note="Fructose 1,6-bisphosphate aldolase; required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress; N-terminally propionylated in vivo" /db_xref="GeneID:853805" /db_xref="SGD:S000001543" ORIGIN 1 mgveqilkrk tgvivgedvh nlftyakehk faipainvts sstavaalea ardskspiil 61 qtsnggaayf agkgisnegq nasikgaiaa ahyirsiapa ygipvvlhsd hcakkllpwf 121 dgmleadeay fkehgeplfs shmldlseet deenistcvk yfkrmaamdq wlemeigitg 181 geedgvnnen adkedlytkp eqvynvykal hpispnfsia aafgnchgly agdialrpei 241 laehqkytre qvgckeekpl flvfhggsgs tvqefhtgid ngvvkvnldt dcqyayltgi 301 rdyvlnkkdy imspvgnpeg pekpnkkffd prvwvregek tmgakitksl etfrttntl // LOCUS NP_012864 441 aa linear PLN 30-JUN-2025 DEFINITION cleavage polyadenylation factor subunit MPE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012864 VERSION NP_012864.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179625.1 REFERENCE 1 (residues 1 to 441) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 441) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 441) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 441) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09098. Method: conceptual translation. FEATURES Location/Qualifiers source 1..441 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..441 /product="cleavage polyadenylation factor subunit MPE1" /calculated_mol_wt="49516" Region 1..441 /region_name="COG5222" /note="Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]" /db_xref="CDD:227547" CDS 1..441 /gene="MPE1" /locus_tag="YKL059C" /coded_by="NM_001179625.1:1..1326" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:35584695|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0006369 termination of RNA polymerase II transcription [PMID:35584695]" /experiment="EXISTENCE:direct assay:GO:0036002 pre-mRNA binding [PMID:35584695|PMID:25135474]" /experiment="EXISTENCE:genetic interaction:GO:0016567 protein ubiquitination [PMID:25135474]" /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:32009536]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:25135474]" /experiment="EXISTENCE:mutant phenotype:GO:0036002 pre-mRNA binding [PMID:25135474]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:32009536]" /note="Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase; detects polyadenylation signal in nascent pre-mRNA and triggers 3' end formation of mRNA via cleavage and polyadenylation; binds pre-mRNA via zinc knuckle and RING finger; E3 ubiquitin ligase involved in polyubiquitination of endonuclease Ysh1p; contains a ubiquitin-like (UBL) domain, a RNA-binding zinc knuckle motif and a RING finger domain; relocalizes to cytosol in response to hypoxia; homolog of human RBBP6" /db_xref="GeneID:853806" /db_xref="SGD:S000001542" ORIGIN 1 msstifyrfk sqrntsrilf dgtgltvfdl kreiiqenkl gdgtdfqlki ynpdteeeyd 61 ddafviprst svivkrspai ksfsvhsrlk gnvgaaalgn atryvtgrpr vlqkrqhtat 121 ttanvsgtte eeriasmfat qenqweqtqe emsaatpvff ksqtnknsaq enegppppgy 181 mcyrcggrdh wikncptnsd pnfegkrirr ttgipkkflk sieidpetmt peemaqrkim 241 itdegkfvvq vedkqswedy qrkrenrqid gdetiwrkgh fkdlpddlkc pltggllrqp 301 vktskccnid fskealenal vesdfvcpnc etrdilldsl vpdqdkekev etflkkqeel 361 hgsskdgnqp etkkmklmdp tgtaglnnnt slptsvnngg tpvppvplpf gippfpmfpm 421 pfmpptatit nphqadaspk k // LOCUS NP_012865 122 aa linear PLN 30-JUN-2025 DEFINITION transcription initiation factor IIA subunit gamma [Saccharomyces cerevisiae S288C]. ACCESSION NP_012865 VERSION NP_012865.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179624.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 122) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09099. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..122 /product="transcription initiation factor IIA subunit gamma" /calculated_mol_wt="13327" Region 3..122 /region_name="TOA2" /note="Transcription initiation factor IIA, gamma subunit [Transcription]; COG5123" /db_xref="CDD:227452" CDS 1..122 /gene="TOA2" /locus_tag="YKL058W" /coded_by="NM_001179624.1:1..369" /experiment="EXISTENCE:direct assay:GO:0005672 transcription factor TFIIA complex [PMID:7862117]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:7862117]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:7604282]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:15132995]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:15132995]" /note="TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa1p, for ribosomal protein gene transcription in vivo; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853807" /db_xref="SGD:S000001541" ORIGIN 1 mavpgyyely rrstignslv daldtlisdg rieaslamrv letfdkvvae tlkdntqskl 61 tvkgnldtyg fcddvwtfiv kncqvtveds hrdasqngsg dsqsvisvdk lrivacnskk 121 se // LOCUS NP_012866 1037 aa linear PLN 30-JUN-2025 DEFINITION Nup120p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012866 VERSION NP_012866.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179623.1 REFERENCE 1 (residues 1 to 1037) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1037) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1037) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1037) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09100. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1037 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1037 /product="Nup120p" /calculated_mol_wt="120317" Region 91..495 /region_name="Nup160" /note="Nucleoporin Nup120/160; pfam11715" /db_xref="CDD:432020" CDS 1..1037 /gene="NUP120" /locus_tag="YKL057C" /gene_synonym="RAT2" /coded_by="NM_001179623.1:1..3114" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:11823431]" /experiment="EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:15725626]" /experiment="EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:22110603]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:17538013|PMID:16418532]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:8557736|PMID:8565072|PMID:8557737]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:8557736]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:22331846]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16418532]" /experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16418532]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22110603]" /experiment="EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:8557737|PMID:8565072|PMID:9725905|PMID:8557736|PMID: 22331846]" /note="Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP160" /db_xref="GeneID:853808" /db_xref="SGD:S000001540" ORIGIN 1 maclsridan llqyyekpep nntvdlyvsn nsnnnglkeg dksistpvpq pygseysncl 61 llsnseyicy hfssrstllt fyplsdayhg ktinihlpna smnqrytlti qeveqqllvn 121 vilkdgsflt lqlplsflfs santlngewf hlqnpydftv rvphflfyvs pqfsvvfled 181 ggllglkkvd gvhyepllfn dnsylksltr ffsrssksdy dsviscklfh erylivltqn 241 chlkiwdlts ftliqdydmv sqsdsdpshf rkveavgeyl slynntlvtl lplenglfqm 301 gtllvdssgi ltytfqnnip tnlsasaiws ivdlvltrpl elnveasyln livlwksgta 361 sklqilnvnd esfknyewie svnkslvdlq sehdldivtk tgdvergfcn lksrygtqif 421 eraqqilsen kiimahnede eylanletil rdvktafnea ssitlygdei ilvncfqpyn 481 hslyklnttv enwfynmhse tdgselfkyl rtlngfastl sndvlrsisk kfldiitgel 541 pdsmttvekf tdifknclen qfeitnlkil fdelnsfdip vvlndlinnq mkpgifwkkd 601 fisaikfdgf tsiisleslh qllsihyrit lqvlltfvlf dldteifgqh istlldlhyk 661 qflllnlyrq dkcllaevll kdssefsfgv kffnygqlia yidslnsnvy nasitensff 721 mtffrsyiie ntshknirff lenvecpfyl rhnevqefmf amtlfscgnf dqsyeifqlh 781 dypeaindkl ptfledlkse nyhgdsiwkd llctftvpyr hsafyyqlsl lfdrnnsqef 841 alkcisksae yslkeiqiee lqdfkekqhi hylnllihfr mfeevldvlr lgheclsdtv 901 rtnflqlllq ediysrdffs tllrlcnahs dngelylrtv dikivdsils qnlrsgdwec 961 fkklycfrml nkseraaaev lyqyilmqad ldvirkrkcy lmvinvlssf dsaydqwiln 1021 gskvvtltdl rdelrgl // LOCUS NP_012867 167 aa linear PLN 30-JUN-2025 DEFINITION Tma19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012867 VERSION NP_012867.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179622.1 REFERENCE 1 (residues 1 to 167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 167) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09101. Method: conceptual translation. FEATURES Location/Qualifiers source 1..167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..167 /product="Tma19p" /calculated_mol_wt="18610" Region 1..161 /region_name="TCTP" /note="Translationally controlled tumour protein; pfam00838" /db_xref="CDD:459957" CDS 1..167 /gene="TMA19" /locus_tag="YKL056C" /gene_synonym="MMI1" /coded_by="NM_001179622.1:1..504" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16806052]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16806052]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:16702403]" /experiment="EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:31936125]" /note="Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress; homolog of human TPT1" /db_xref="GeneID:853809" /db_xref="SGD:S000001539" ORIGIN 1 miiykdifsn dellsdayda klvddviyea dcamvnvggd nidiganpsa eggdddveeg 61 aemvnnvvhs frlqqtafdk ksfltyikgy mkavkaklqe tnpeevpkfe kgaqtyvkkv 121 igsfkdweff tgesmdpdam vvmlnyredg ttpfvaiwkh giveeki // LOCUS NP_012868 278 aa linear PLN 30-JUN-2025 DEFINITION 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) [Saccharomyces cerevisiae S288C]. ACCESSION NP_012868 VERSION NP_012868.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179621.2 REFERENCE 1 (residues 1 to 278) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 278) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 278) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 278) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09102. Method: conceptual translation. FEATURES Location/Qualifiers source 1..278 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..278 /product="3-oxoacyl-[acyl-carrier-protein] reductase (NADPH)" /EC_number="1.1.1.100" /calculated_mol_wt="31053" Region 7..275 /region_name="SDR_c" /note="classical (c) SDRs; cd05233" /db_xref="CDD:212491" Site order(11,13..16,35..37,74..76,120..122,143,181..183,198, 202,228..231,234..235) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:212491" Site order(144,183,198,202) /site_type="active" /db_xref="CDD:212491" CDS 1..278 /gene="OAR1" /locus_tag="YKL055C" /coded_by="NM_001179621.2:1..837" /experiment="EXISTENCE:direct assay:GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [PMID:19571038]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [PMID:9388293]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9388293]" /experiment="EXISTENCE:mutant phenotype:GO:0006631 fatty acid metabolic process [PMID:9388293]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:9388293]" /note="Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase; may comprise a type II mitochondrial fatty acid synthase along with Mct1p; human homolog CBR4 complements yeast null mutant" /db_xref="GeneID:853810" /db_xref="SGD:S000001538" ORIGIN 1 mhylpvaivt gatrgigkai cqklfqkgls ciilgstkes iertaidrgq lqsglsyqrq 61 caiaidfkkw phwldyesyd gieyfkdrpp lkqkystlfd pcnkwsnner ryyvnllinc 121 agltqeslsv rttasqiqdi mnvnfmspvt mtnicikymm ksqrrwpels gqsarptivn 181 issilhsgkm kvpgtsvysa skaalsrfte vlaaemeprn ircftispgl vkgtdmiqnl 241 pveakemler tigasgtsap aeiaeevwsl ysrtalet // LOCUS NP_012869 738 aa linear PLN 30-JUN-2025 DEFINITION DNA damage-responsive RNA polymerase-degradation factor DEF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012869 VERSION NP_012869.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179620.1 REFERENCE 1 (residues 1 to 738) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 738) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 738) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 738) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 738) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 738) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 738) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09103. Method: conceptual translation. FEATURES Location/Qualifiers source 1..738 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..738 /product="DNA damage-responsive RNA polymerase-degradation factor DEF1" /calculated_mol_wt="83842" Region 23..61 /region_name="CUE_DEF1_like" /note="CUE domain found in fungal RNA polymerase II degradation factor 1 (DEF1) and similar proteins; cd14368" /db_xref="CDD:270551" CDS 1..738 /gene="DEF1" /locus_tag="YKL054C" /gene_synonym="VID31" /coded_by="NM_001179620.1:1..2217" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11859374]" /experiment="EXISTENCE:direct assay:GO:0062058 transcription factor TFIIH holo complex binding [PMID:29180430]" /experiment="EXISTENCE:genetic interaction:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:15863512]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:11859374]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11859374]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:11859374]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:24465179]" /experiment="EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:29180430]" /note="RNAPII degradation factor; forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; interacts with general transcription factor TFIIH; mutant is deficient in Zip1p loading onto chromosomes during meiosis; null mutant is prone to self-diploidization; null mutation can be functionally complemented by human UBAP2 and UBAP2" /db_xref="GeneID:853811" /db_xref="SGD:S000001537" ORIGIN 1 mstqfrksnh nshsskklnp alkskidtlt elfpdwtsdd lidivqeydd letiidkits 61 gavtrwdevk kpakkekyek keqqhsyvpq qhlpnpeddi tykssnnsns ftstkhnssn 121 nytqarnkkk vqtprahttg khvnldkgkh vpskpvsntt swaaavsvdt khdvpqdsnd 181 nnneeleaqg qqaqeknqek eqeeqqqqeg hnnkeehkqi eqpslsskkt tsrtsasqpk 241 kmswaaiatp kpkavkktes plenvaelkk eisdikkddq kseaseekvn eqetsaqeqe 301 eetaepseen edrvpevdge evqeeaekke qvkeeeqtae eleqeqdnva apeeevtvve 361 ekveisavis eppedqantv pqpqqqsqqp qqpqqpqqpq qpqqpqqqqq pqqpqqpqqq 421 lqqqqqqqqq pvqaqaqaqe eqlsqnyytq qqqqqyaqqq hqlqqqylsq qqqyaqqqqq 481 hpqpqsqqpq sqqspqsqkq gnnvaaqqyy myqnqfpgys ypgmfdsqgy aygqqyqqla 541 qnnaqtsgna nqynfqqgyg qagantaaan ltsaaaaaaa spatahaqpq qqqpyggsfm 601 pyyahfyqqs fpygqpqygv agqypyqlpk nnynyyqtqn gqeqqspnqg vaqhsedsqq 661 kqsqqqqqqq pqgqpqpevq mqngqpvnpq qqmqfqqyyq fqqqqqqaaa aaaaaaqqgv 721 pygyngydyn sknsrgfy // LOCUS NP_012870 86 aa linear PLN 30-JUN-2025 DEFINITION Mdm35p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012870 VERSION NP_012870.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184336.1 REFERENCE 1 (residues 1 to 86) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 86) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 86) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 86) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09104. Method: conceptual translation. FEATURES Location/Qualifiers source 1..86 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..86 /product="Mdm35p" /calculated_mol_wt="9581" Region 7..75 /region_name="UPF0203" /note="Uncharacterized protein family (UPF0203); pfam05254" /db_xref="CDD:461604" CDS 1..86 /gene="MDM35" /locus_tag="YKL053C-A" /coded_by="NM_001184336.1:1..261" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:17095012]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:27354379]" /experiment="EXISTENCE:direct assay:GO:0045332 phospholipid translocation [PMID:26235513]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266]" /experiment="EXISTENCE:mutant phenotype:GO:0033108 mitochondrial respiratory chain complex assembly [PMID:19703468]" /note="Mitochondrial intermembrane space protein; forms complex with Ups2p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853812" /db_xref="SGD:S000007243" ORIGIN 1 mgnimsasfa pectdlktky dscfnewyse kflkgksven ecskqwyayt tcvnaalvkq 61 gikpaldear eeapfenggk lkevdk // LOCUS NP_012872 292 aa linear PLN 30-JUN-2025 DEFINITION Ask1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012872 VERSION NP_012872.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179618.1 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 292) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09105. On Nov 27, 2009 this sequence version replaced NP_012872.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..292 /product="Ask1p" /calculated_mol_wt="31941" Region 10..73 /region_name="DASH_Ask1" /note="DASH complex subunit Ask1; pfam08655" /db_xref="CDD:430135" CDS 1..292 /gene="ASK1" /locus_tag="YKL052C" /coded_by="NM_001179618.1:1..879" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:16777964|PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15664196|PMID:15640796]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:20479465|PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479468|PMID:20479465]" /note="Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; sumoylated in an Mms21p-dependent manner; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853814" /db_xref="SGD:S000001535" ORIGIN 1 mdsaskeetl ekldqeitvn lqkidsnlsf cfhkitqdii phvatyseic erimdstewl 61 gtmfqetglv nlqanaaapv gnapvkslvs nnvgifptsa eeasrqsqtd ngpneadsav 121 hvnrdvhsmf nndsiddfht anitstgqil klpdssdedt gseavpsreq tdltgeghgg 181 addeqdesti qrqsrkrkis lllqqqygss ssmvpspivp nkmrkqlahe ehinndgdnd 241 densnniess plkqghhhpk gqaddnnegp deeestkevp kpgtiihfst nr // LOCUS NP_012873 353 aa linear PLN 30-JUN-2025 DEFINITION Sfk1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012873 VERSION NP_012873.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179617.1 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 353) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09106. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..353 /product="Sfk1p" /calculated_mol_wt="40332" Region 10..285 /region_name="Frag1" /note="Frag1/DRAM/Sfk1 family; pfam10277" /db_xref="CDD:431193" CDS 1..353 /gene="SFK1" /locus_tag="YKL051W" /coded_by="NM_001179617.1:1..1062" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12015967]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0007033 vacuole organization [PMID:12015967]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:12015967]" /experiment="EXISTENCE:genetic interaction:GO:0061093 negative regulation of phospholipid translocation [PMID:29540528]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:12015967]" /experiment="EXISTENCE:mutant phenotype:GO:0061093 negative regulation of phospholipid translocation [PMID:29540528]" /note="Protein that regulates phospholipid asymmetry at plasma membrane; may act to generate normal levels of PI4P; may act together with or upstream of Stt4p; at least partially mediates proper localization of Stt4p to the plasma membrane" /db_xref="GeneID:853815" /db_xref="SGD:S000001534" ORIGIN 1 miqfkspgnw lfivpwiafi pwygmliaml icwasqghpi ywfmhseqfp vyisdigatn 61 lrplfiscag wqglgyvitv aleffqrsgy lpfqlkkkdp sisdstsyae klhsgkylmp 121 pyytkdernl ifaafvlgsi gelallfssi fstalyhrvh iamvsvfvvf mflstcclia 181 eyflmgrhya svhplasphf npqsseksfn qdyntvdelp wykwkghvwn kftisatlkv 241 iwltlavvwa icfgaindrs ksacfewlla fwfgiifmil sadfylggry rqsryfnhve 301 sfsgyykydk alglyhsedv lpsddnagvi atetassniy nnsssnesiq vvv // LOCUS NP_012874 922 aa linear PLN 30-JUN-2025 DEFINITION Lpx2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012874 VERSION NP_012874.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179616.1 REFERENCE 1 (residues 1 to 922) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 922) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 922) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 922) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 922) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 922) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 922) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09107. Method: conceptual translation. FEATURES Location/Qualifiers source 1..922 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..922 /product="Lpx2p" /calculated_mol_wt="103013" Region 347..466 /region_name="Eisosome1" /note="Eisosome protein 1; pfam12757" /db_xref="CDD:432763" Region 396..>603 /region_name="YhaN" /note="Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; COG4717" /db_xref="CDD:443752" CDS 1..922 /gene="LPX2" /locus_tag="YKL050C" /coded_by="NM_001179616.1:1..2769" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /note="Peroxisomal matrix-localized lipase; target of SCFCdc4 ubiquitin ligase complex; peroxisomal, nuclear and cytosolic localization is dependent on the presence of oleate; transcription is regulated by Azf1p; LPX2 has a paralog, EIS1, that arose from the whole genome duplication" /db_xref="GeneID:853816" /db_xref="SGD:S000001533" ORIGIN 1 mslisalqtt dvesvqtspe qiterkavrv stlqeslhss emhraapetp rsisnsvhkl 61 ktiystyqqs gqplskeaif rakqkygiln tpanyktlgl gdsksesvdl aarlaskrtk 121 vspddcveta ieqkargeaf kvtfskiplt ppedvpitvn lglkgrrdfl trlaaqkala 181 fspsldnsmk gtsdsssvkk krfsgapign efdanlvnpq hpagfksldl skvldgaerr 241 aisrvndrly pqkvnfkngl qssdqsgvsk ankevfkkgt leklehsaeq fleshagner 301 qrlsdqqymc akgaadavkd ldpktledpd faareaqkkl yikqvaspvv lneaqklanr 361 klqdidsrdt ymllfgnqay nklavnialq hysvkqeekk kiylggglwm tpeevnavak 421 klispvvnei derasrqrdv dkdierrsrv ldqeyedgns merakeqndg qlllamaskq 481 qqekeakkae egqrydqfvq kmniklqqke kelenarenr enlrnelqer lsknlsgend 541 elndwndace rdlknssieh yyavrshfdn lgnsergyde lleerskiqv eierlvasia 601 ehktaihgfg etadaggaip avqkqkiptr kdlldatvnd plvisaemak eeaemateec 661 mlkelqvdem iiirnimlre cekkleeeke takrsrrgte esknnsnfsr dvimstpdnn 721 ekvtpigksa spkdvvksrf lstyntgkdi dssasarsit gvsgvlddgp ktptsnkene 781 liddevksyk vhqavdgtge dsiankrdks srpaansggs itieqflfnk nadkqglskt 841 esvtmkrepv vdqmdskkgh dfthcndngr rsfsgfsqgs iendysnevt ddqddqegse 901 irvrdsndsn tspkesffke vi // LOCUS NP_012875 229 aa linear PLN 30-JUN-2025 DEFINITION centromeric DNA-binding histone H3-like protein CSE4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012875 VERSION NP_012875.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179615.1 REFERENCE 1 (residues 1 to 229) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 229) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 229) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 229) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09108. On Jan 21, 2003 this sequence version replaced NP_012875.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..229 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..229 /product="centromeric DNA-binding histone H3-like protein CSE4" /calculated_mol_wt="26710" Region 124..229 /region_name="H3" /note="Histone H3; smart00428" /db_xref="CDD:128705" Site order(130..138,140,154..157,160,163,177..180,210..212,214) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:467036" Site order(135,138,141..142,145..146,148,150,152..153,157..158, 160..162,164..165,167,169,173,176..179,181..182,185..186, 189..191,193..195,197..199,202,211..215,219,222) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467036" Site order(139,142..143,146..147,149,188,192,195,202,206,211) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467036" Site order(200,203..204,207..208,210,216..217,220..221,223..225) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:467036" CDS 1..229 /gene="CSE4" /locus_tag="YKL049C" /gene_synonym="CSL2" /coded_by="NM_001179615.1:1..690" /experiment="EXISTENCE:direct assay:GO:0000278 mitotic cell cycle [PMID:23623551]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:37436802]" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:16207811|PMID:23623551]" /experiment="EXISTENCE:direct assay:GO:0005729 2-micrometer circle DNA [PMID:16966420]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:23623551|PMID:11063678]" /experiment="EXISTENCE:direct assay:GO:0043505 CENP-A containing nucleosome [PMID:11063678|PMID:19782029]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:16966420]" /experiment="EXISTENCE:genetic interaction:GO:0000779 condensed chromosome, centromeric region [PMID:11063678]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:7698647]" /experiment="EXISTENCE:mutant phenotype:GO:0030543 2-micrometer plasmid partitioning [PMID:16966420]" /experiment="EXISTENCE:mutant phenotype:GO:0051382 kinetochore assembly [PMID:16207811]" /experiment="EXISTENCE:mutant phenotype:GO:0061644 protein localization to CENP-A containing chromatin [PMID:28980861]" /note="Centromeric histone H3-like protein; associates with promoters, accessible chromatin and RNAPII-bound regions; centromeric association promotes kinetochore assembly and Sgo1p association with CEN chromatin; Ipl1p-dependent phosphorylation destabilizes defective kinetochores promoting biorientation; phosphorylation by Cdc7p maintains Cse4p at kinetochores and promotes chromosome segregation; R37 methylation regulates kinetochore function and chromosome segregation; complements human homolog CENPA" /db_xref="GeneID:853817" /db_xref="SGD:S000001532" ORIGIN 1 msskqqwvss aiqsdssgrs lsnvnrlagd qqsindrals llqrtratkn lfprreerrr 61 yessksdldi etdyedqagn leieteneee aemetevpap vrthsyaldr yvrqkrrekq 121 rkqslkrvek kytpselaly eirkyqrstd lliskipfar lvkevtdeft tkdqdlrwqs 181 maimalqeas eaylvglleh tnllalhakr itimkkdmql arrirgqfi // LOCUS NP_012876 640 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase ELM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012876 VERSION NP_012876.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179614.1 REFERENCE 1 (residues 1 to 640) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 640) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 640) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 640) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09109. Method: conceptual translation. FEATURES Location/Qualifiers source 1..640 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..640 /product="serine/threonine protein kinase ELM1" /EC_number="2.7.11.1" /calculated_mol_wt="72019" Region 95..402 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(95..97,100,102,115,117,182,200..203,259,263..264,266, 277..278) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270910" CDS 1..640 /gene="ELM1" /locus_tag="YKL048C" /gene_synonym="LDB9" /coded_by="NM_001179614.1:1..1923" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:27053666]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:9180279|PMID:12847291|PMID:16201971]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000023 maltose metabolic process [PMID:34140941]" /experiment="EXISTENCE:mutant phenotype:GO:0000144 cellular bud neck septin ring [PMID:27053666]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:10725226]" /experiment="EXISTENCE:mutant phenotype:GO:0000902 cell morphogenesis [PMID:9427410|PMID:16607009]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:10725226]" /experiment="EXISTENCE:mutant phenotype:GO:0007117 budding cell bud growth [PMID:10234786]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9891070]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:15340085]" /experiment="EXISTENCE:mutant phenotype:GO:1902935 protein localization to septin ring [PMID:27053666]" /note="Serine/threonine protein kinase; regulates the orientation checkpoint, the morphogenesis checkpoint and the metabolic switch from fermentative to oxidative metabolism by phosphorylating the activation loop of Kin4p, Hsl1p and Snf1p respectively; cooperates with Hsl7p in recruiting Hsl1p to the septin ring, a prerequisite for subsequent recruitment, phosphorylation, and degradation of Swe1p; forms part of the bud neck ring; regulates cytokinesis" /db_xref="GeneID:853818" /db_xref="SGD:S000001531" ORIGIN 1 msprqliptl ipewaplsqq sciredelds ppitptsqts sfgssfsqqk ptystiigen 61 ihtildeirp yvkkitvsdq dkktinqytl gvsagsgqfg yvrkaysstl gkvvavkiip 121 kkpwnaqqys vnqvmrqiql wkskgkittn msgneamrlm niekcrweif aasrlrnnvh 181 ivrlieclds pfsesiwivt nwcslgelqw krdddedilp qwkkivisnc svstfakkil 241 edmtkgleyl hsqgcihrdi kpsnilldee ekvaklsdfg sciftpqslp fsdanfedcf 301 qrelnkivgt pafiapelch lgnskrdfvt dgfkldiwsl gvtlycllyn elpffgenef 361 etyhkiievs lsskingntl ndlvikrlle kdvtlrisiq dlvkvlsrdq pidsrnhsqi 421 ssssvnpvrn egpvrrffgr lltkkgkkkt sgkgkdkvlv satskvtpsi hideepdkec 481 fsttvlrssp dssdycsslg eeaiqvtdfl dtfcrsnesl pnltvnndkq nsdmktdrse 541 ssshsslkip tpikamirlk sspkengnrt hincsqdkps splmdrtvgk rtvnnsgark 601 lahssnilnf kayinsedsd iretvedvkt ylnfadngqi // LOCUS NP_012877 516 aa linear PLN 30-JUN-2025 DEFINITION Anr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012877 VERSION NP_012877.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179613.1 REFERENCE 1 (residues 1 to 516) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 516) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 516) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 516) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09110. Method: conceptual translation. FEATURES Location/Qualifiers source 1..516 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..516 /product="Anr2p" /calculated_mol_wt="58764" Region 33..335 /region_name="DENND11" /note="DENN domain-containing protein 11; pfam09804" /db_xref="CDD:430838" CDS 1..516 /gene="ANR2" /locus_tag="YKL047W" /coded_by="NM_001179613.1:1..1551" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093]" /note="hypothetical protein; may have a role in lipid metabolism, based on localization to lipid droplets; predicted to be palmitoylated" /db_xref="GeneID:853819" /db_xref="SGD:S000001530" ORIGIN 1 mnsggeepti kpnvfnitql lnsngekpgi aciflskfdm kkgniiiwsk singaaidls 61 niefkslpag iheqtddvvn fvvpkeldvc qtaktttydy giayfkqnsf diiendnrid 121 rskvqmfslg viidvqnass dskkhfykei yhayaanrys sylesllgqw irqrdldkfd 181 ifekffdenn qghmaensve vfehspkerr hlveylpywt rklgplifpl wkasllqsri 241 lilvpqgesf elcnslaycv flismlpknl ignhvsdeyi kpiftvstsd ipflesfkkg 301 ngyvattsee illykpeiyd ivvkltssst ieespekeve iltasgeqnk atpldlevye 361 klilgelqed astnatcrhh evtepiswlq flidgffllt tagylvapyh lannfkiprh 421 vsgpepnnse iqiaenlvry fhrrtsnlyn dlkdviqkse nidseqpiti aasfltklnl 481 dcfskqdhqf vkdialkwfq rsidisnlpe clgnlc // LOCUS NP_012878 449 aa linear PLN 30-JUN-2025 DEFINITION putative mannan endo-1,6-alpha-mannosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012878 VERSION NP_012878.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179612.1 REFERENCE 1 (residues 1 to 449) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 449) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 449) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 449) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09111. Method: conceptual translation. FEATURES Location/Qualifiers source 1..449 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..449 /product="putative mannan endo-1,6-alpha-mannosidase" /EC_number="3.2.1.101" /calculated_mol_wt="49434" Region 31..378 /region_name="Glyco_hydro_76" /note="Glycosyl hydrolase family 76; pfam03663" /db_xref="CDD:397638" CDS 1..449 /gene="DCW1" /locus_tag="YKL046C" /coded_by="NM_001179612.1:1..1350" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12421307]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009272 fungal-type cell wall biogenesis [PMID:12421307]" /experiment="EXISTENCE:genetic interaction:GO:0007117 budding cell bud growth [PMID:15470258]" /note="Putative mannosidase; GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p" /db_xref="GeneID:853820" /db_xref="SGD:S000001529" ORIGIN 1 mlvnkvigll gvlfatrftn aveldldnye slqnatslia yglmdyytgn qygktvgmfs 61 dpyywweagg awgcmldywf fmdndtynde iiaamihqag ddndyiplnq sttegnddqa 121 fwgiaamtaa ernftnppen epqwlylaqa vfntmalrwd adscggglrw qifvwnsgyd 181 ykntvsngal fhiaarlary tgnqtyvdwa ekvyewmvgv nlisngtyky vydgvsiddn 241 ctkvtsyqwt ynqglllags aylynftgsd lwhtrtkefl nasqvffhdg ivyeaacqgp 301 nscntdqrsf kayfarflgv taqlvpetrn qimswlntsa iaaakscsgg tdghtcglnw 361 fngtwdgmyg lgeqmsalev mvntraldkp apytaenggs svgdgaagtq aqptnlapln 421 itkgskagag iitavigisi vacalwlvf // LOCUS NP_012879 528 aa linear PLN 30-JUN-2025 DEFINITION DNA primase subunit PRI2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012879 VERSION NP_012879.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179611.1 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 528) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09112. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..528 /product="DNA primase subunit PRI2" /calculated_mol_wt="62132" Region 61..507 /region_name="PriL_PriS_Eukaryotic" /note="Eukaryotic core primase: Large subunit, PriL; cd07322" /db_xref="CDD:143474" Site order(229..230,233,237,242..247) /site_type="other" /note="PriL_PriS interface [polypeptide binding]" /db_xref="CDD:143474" CDS 1..528 /gene="PRI2" /locus_tag="YKL045W" /coded_by="NM_001179611.1:1..1587" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:20404922]" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3888995|PMID:3061469]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005658 alpha DNA polymerase:primase complex [PMID:22593576|PMID:3888995]" /experiment="EXISTENCE:direct assay:GO:0006269 DNA replication, synthesis of primer [PMID:2644256]" /experiment="EXISTENCE:genetic interaction:GO:0003899 DNA-directed RNA polymerase activity [PMID:8436268]" /experiment="EXISTENCE:mutant phenotype:GO:0003899 DNA-directed RNA polymerase activity [PMID:8436268]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:2023935]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:10025407]" /note="Subunit of DNA primase; DNA primase is required for DNA synthesis and double-strand break repair" /db_xref="GeneID:853821" /db_xref="SGD:S000001528" ORIGIN 1 mfrqskrria srknfssydd ivkseldvgn tnaanqiils sssseeekkl yarlyeskls 61 fydlppqgei tleqfeiwai drlkilleie sclsrnksik eietiikpqf qkllpfntes 121 ledrkkdyys hfilrlcfcr skelrekfvr aetflfkirf nmltstdqtk fvqsldlpll 181 qfisneekae lshqlyqtvs aslqfqlnln eehqrkqyfq qekfiklpfe nvielvgnrl 241 vflkdgyayl pqfqqlnlls nefasklnqe liktyqylpr lneddrllpi lnhlssgyti 301 adfnqqkanq fsenvddein aqsvwseeis snyplciknl meglkknhhl ryygrqqlsl 361 flkgiglsad ealkfwseaf trngnmtmek fnkeyrysfr hnyglegnri nykpwdchti 421 lskprpgrgd yhgcpfrdws herlsaelrs mkltqaqiis vldscqkgey tiactkvfem 481 thnsasadle igeqthiahp nlyfersrql qkkqqkleke klfnngnh // LOCUS NP_001257684 106 aa linear PLN 30-JUN-2025 DEFINITION Mmo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257684 VERSION NP_001257684.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270755.1 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 106) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35123. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..106 /product="Mmo1p" /calculated_mol_wt="12317" CDS 1..106 /gene="MMO1" /locus_tag="YKL044W" /coded_by="NM_001270755.1:1..321" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /note="hypothetical protein; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the mitochondria; mRNA identified as translated by ribosome profiling data; MMO1 is a non-essential gene" /db_xref="GeneID:853822" /db_xref="SGD:S000001527" ORIGIN 1 mgyvimtfss armserrari iyiwmhlsay kinfpfvqfp tffslfrlqk kaailiknps 61 pfflfflfpy rknstartih qinqavalvl lcvshhltyl psvpsl // LOCUS NP_012881 366 aa linear PLN 30-JUN-2025 DEFINITION Phd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012881 VERSION NP_012881.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179609.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 366) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09113. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..366 /product="Phd1p" /calculated_mol_wt="40515" Region 205..285 /region_name="KilA-N" /note="KilA-N domain; pfam04383" /db_xref="CDD:367917" CDS 1..366 /gene="PHD1" /locus_tag="YKL043W" /coded_by="NM_001179609.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8114741]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:16449570]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8114741]" /experiment="EXISTENCE:mutant phenotype:GO:2000222 positive regulation of pseudohyphal growth [PMID:8114741]" /note="Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication" /db_xref="GeneID:853823" /db_xref="SGD:S000001526" ORIGIN 1 myhvpemrlh yplvntqsna aitptrsydn tlpsfnelsh qstinlpfvq retpnayanv 61 aqlatsptqa ksgyycryya vpfptypqqp qspyqqavlp yatipnsnfq pssfpvmavm 121 ppevqfdgsf lntlhphtel ppiiqntndt svarpnnlks iaaasptvta ttrtpgvsst 181 svlkprvitt mwedenticy qveangisvv rradnnming tkllnvtkmt rgrrdgilrs 241 ekvrevvkig smhlkgvwip ferayilaqr eqildhlypl fvkdiesivd arkpsnkasl 301 tpksspapik qepsdnkhei ateikpksid alsngastqg agelphlkin hidteaqtsr 361 aknels // LOCUS NP_012882 363 aa linear PLN 30-JUN-2025 DEFINITION Spc42p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012882 VERSION NP_012882.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179608.3 REFERENCE 1 (residues 1 to 363) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 363) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 363) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 363) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09114. On Jul 30, 2012 this sequence version replaced NP_012882.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..363 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..363 /product="Spc42p" /calculated_mol_wt="42140" Region 63..129 /region_name="Spc42p" /note="Spindle pole body component Spc42p; pfam11544" /db_xref="CDD:402925" CDS 1..363 /gene="SPC42" /locus_tag="YKL042W" /coded_by="NM_001179608.3:1..1092" /experiment="EXISTENCE:direct assay:GO:0005821 intermediate layer of spindle pole body [PMID:9215630]" /experiment="EXISTENCE:direct assay:GO:0005823 central plaque of spindle pole body [PMID:9215630]" /experiment="EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:9215630]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:9153752]" /note="Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane" /db_xref="GeneID:853824" /db_xref="SGD:S000001525" ORIGIN 1 mngsptpkry sskssrlydd yynipyqysn ptpmnrdynd vgsrinadkl vpeeykrnte 61 finkavqqnk elnfklrekq neifelkkia etlrskleky vditkkledq nlnlqikisd 121 lekklsdans tfkemrfpkv kdpmvdddpv senydqinvp khrapdatgn prttnkvsnt 181 sdqdsrlkai ertlsvltny vmrsedgnnd rmsplpspln tilpinnrln fqepkrynpt 241 vkvnpsdddi mmyesaelkr veeeieelkr kilvrkkhdl rklslnnqlq elqsmmdgdd 301 nikldnvskh nhathrhssq ssrdyspssd aclecsndly eknrvkpenn msetfatptp 361 nnr // LOCUS NP_012883 224 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-III subunit protein VPS24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012883 VERSION NP_012883.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179607.1 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 224) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09115. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..224 /product="ESCRT-III subunit protein VPS24" /calculated_mol_wt="26111" Region 19..189 /region_name="Snf7" /note="pfam03357" /db_xref="CDD:460896" CDS 1..224 /gene="VPS24" /locus_tag="YKL041W" /gene_synonym="DID3; VPL26" /coded_by="NM_001179607.1:1..675" /experiment="EXISTENCE:direct assay:GO:0000815 ESCRT III complex [PMID:12194857]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9606181]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:9606181]" /experiment="EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:19234443]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /note="One of four subunits of the ESCRT-III complex; forms an endosomal sorting complex required for transport III (ESCRT-III) subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway" /db_xref="GeneID:853825" /db_xref="SGD:S000001524" ORIGIN 1 mdyikkaiwg pdpkeqqrri rsvlrkngrn iekslreltv lqnktqqlik ksakkndvrt 61 vrlyakelyq inkqydrmyt sraqldsvrm kideairmnt lsnqmadsag lmrevnslvr 121 lpqlrntmie lekelmksgi isemvddtme svgdvgeemd eavdeevnki veqytnekfk 181 nvdqvptvel aaneeeqeip dekvdeeadr mvnemrerlr alqn // LOCUS NP_012884 256 aa linear PLN 30-JUN-2025 DEFINITION Nfu1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012884 VERSION NP_012884.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179606.3 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 256) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09116. On Jul 30, 2012 this sequence version replaced NP_012884.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..256 /product="Nfu1p" /calculated_mol_wt="29043" Region 24..117 /region_name="Nfu_N" /note="Scaffold protein Nfu/NifU N terminal; smart00932" /db_xref="CDD:214919" Region 157..225 /region_name="NifU" /note="NifU-like domain; pfam01106" /db_xref="CDD:460066" CDS 1..256 /gene="NFU1" /locus_tag="YKL040C" /gene_synonym="NUB1" /coded_by="NM_001179606.3:1..771" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10468587]" /experiment="EXISTENCE:genetic interaction:GO:0044572 [4Fe-4S] cluster assembly [PMID:27532773]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:10588895|PMID:10468587|PMID:12065597]" /experiment="EXISTENCE:mutant phenotype:GO:0044572 [4Fe-4S] cluster assembly [PMID:27532773]" /experiment="EXISTENCE:physical interaction:GO:0044572 [4Fe-4S] cluster assembly [PMID:27532773]" /note="Protein involved in Fe-S cluster transfer to mitochondrial clients; protects [4Fe-4S] clusters from damage due to oxidative stress; acts along with Bol3 at a late step in the transfer of [4Fe-4S] clusters from the ISA complex to client proteins; Fe-S loaded homodimer at steady state; similar to NifU, a bacterial protein required for Fe/S cluster maturation; ortholog of the human NFU1, mutations of which are associated with Multiple Mitochondria Dysfunctions Syndrome (MMDS1)" /db_xref="GeneID:853826" /db_xref="SGD:S000001523" ORIGIN 1 mfksvaklgk spifylnsqr lihiktlttp nenalkflst dgemlqtrgs ksivikntde 61 nlinhsklaq qiflqcpgve slmigddflt inkdrmvhwn sikpeiidll tkqlaygedv 121 iskefhavqe eegeggykin mpkfelteed eevselieel idtrirpail edggdidyrg 181 wdpktgtvyl rlqgactscs ssevtlkygi esmlkhyvde vkeviqimdp eqeialkefd 241 klekklessk ntshek // LOCUS NP_012885 523 aa linear PLN 30-JUN-2025 DEFINITION Ptm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012885 VERSION NP_012885.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179605.1 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 523) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09117. On Dec 19, 2005 this sequence version replaced NP_012885.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..523 /product="Ptm1p" /calculated_mol_wt="59888" Region 157..447 /region_name="Lung_7-TM_R" /note="Lung seven transmembrane receptor; pfam06814" /db_xref="CDD:369089" CDS 1..523 /gene="PTM1" /locus_tag="YKL039W" /coded_by="NM_001179605.1:1..1572" /note="hypothetical protein; copurifies with late Golgi vesicles containing the v-SNARE Tlg2p; PTM1 has a paralog, YHL017W, that arose from the whole genome duplication" /db_xref="GeneID:853827" /db_xref="SGD:S000001522" ORIGIN 1 mrvyqfcrpf qlftcflcyl lvfvkankek isqknyqvca gmyskedwkg kidpfisfnl 61 kkisglsdes dpglvvaiyd fqdfehlgvq lpdeemyyic ddyaidigic eeenrdefiv 121 qdvvydpyts tnrslanpim tfsqnevglh dtrypiketg fycvtafrss tstkfnavvn 181 frnaygqlag teinklplyg llavayvvam alysfafwkh khellplqky llaffvflta 241 etifvwayyd lknekgdtag ikvymvflsi ltagkvtfsf fllliialgy givypklnkt 301 lmrrcqmyga ltyaicigfl iqsyltdmea psplilitli pmalaliify ymiirsmtkt 361 viylkeqrqi vklnmykkll yiiyasflsv lagsivssfi yvgmntidmi eknwrsrffv 421 tdfwptlvyf ivfvtiaflw rptdtsymla asqqlptdpe nvadfdlgdl qsfddqddas 481 iitgergide ddlnlnftdd eeghdnvnnh sqghgpvsps ptk // LOCUS NP_012886 1170 aa linear PLN 30-JUN-2025 DEFINITION Rgt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012886 VERSION NP_012886.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179604.3 REFERENCE 1 (residues 1 to 1170) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1170) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1170) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1170) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09118. On Jul 30, 2012 this sequence version replaced NP_012886.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1170 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1170 /product="Rgt1p" /calculated_mol_wt="128110" Region 41..85 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(42,46,51..54,56,59,71) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(47,50,57,66,69,76) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..1170 /gene="RGT1" /locus_tag="YKL038W" /coded_by="NM_001179604.3:1..3513" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12861007]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12861007|PMID:8887670|PMID:12239282]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8887670]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12861007]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12861007]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8887670]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8887670]" /experiment="EXISTENCE:genetic interaction:GO:0006006 glucose metabolic process [PMID:8013905]" /note="Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; recruits Tup1p/Cyc8p to target gene promoters; RGT1 has a paralog, EDS1, that arose from the whole genome duplication" /db_xref="GeneID:853828" /db_xref="SGD:S000001521" ORIGIN 1 mnelntvstn ssdstknggt snspddmdsa aaashaikkr tkasracdqc rkkkikcdyk 61 dekgvcsncq rngdrcsfdr vplkrgpskg ytrstshprt neiqdhnnsr syntfdnsnn 121 tlnnntgnsg dnginsntvp stpsrsnsvl lppltqyipq aggippsfqn paiqstmpag 181 nigqqqfwkv pyhefqhqrk gsidslqsdi svrtlnpneq lsyntvqqsp itnkhtndsg 241 nangsvtgsg sasgsggyws firtsgllap tddhngeqtr rsssipsllr ntsnslllgg 301 qpqlpppqqq sqpqahqqkl qqgqnlysys qfsqqqpynp sissfgqfaa ngfhsrqgsv 361 aseamspsap amftststnp vnvaqqtqrp qgqqvpqfss eldgnkrrqs apvsvtlstd 421 rlngnennng einnnngsnn sgsskdtsqh sqesvttpaa leasspgstp qrstkkrrks 481 yvskktkpkr dssisitskd sahpmttsst iaygqisdvd lidtyyefih vgfpiiplnk 541 ttltsdlllv ntqpisnihe vnsyvilwfr nslellvrva lkqkpggkff dnivgvalsp 601 sndnnkagft tatarddaek trrdshnevq dtlevqsvfi aalnecfqki vdihpkfren 661 ndqispkikv iylstfilln yilafvgydn sfvlgmsvti fnefklykll lfpepdindv 721 kppvdeevst gngntktsef eigsesaghm npsnspnsmd enishysvlf krlyvllsvf 781 dslqscafgg pkllnisiqg sterffsndl gskwcleqsq lrlksvlqsl klgelmselt 841 rnrismngnr kpgfditnss sllseyvetq plsvaqlfck lligkhnfin cllslydsea 901 gvysdltldl sskiadslcs lisiilqvlt lilrlnptns idfnyrppnp pannptvqeg 961 psamgsspva gnlsaappse gnpdfykkll glkqdtgtil sdlcrgiisp faiailhevy 1021 nitelvkqmp tslisimmta tttqntqdtk ksqdlvmkls nsmnevvqit svltmikpfk 1081 ifehelnkpi msltgglsst trndvmwpks gqglressvm ktllderrts gtqpttapva 1141 aeeprlenva lenfvsigwk llddselgwy // LOCUS NP_012887 118 aa linear PLN 30-JUN-2025 DEFINITION Aim26p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012887 VERSION NP_012887.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179603.1 REFERENCE 1 (residues 1 to 118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 118) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09119. Method: conceptual translation. FEATURES Location/Qualifiers source 1..118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..118 /product="Aim26p" /calculated_mol_wt="12805" CDS 1..118 /gene="AIM26" /locus_tag="YKL037W" /coded_by="NM_001179603.1:1..357" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /note="hypothetical protein; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT" /db_xref="GeneID:853829" /db_xref="SGD:S000001520" ORIGIN 1 mqtmggehll lsqlkgsffl lllayffrgr spyyarcyrr lavtpgaiti aiaiatdsip 61 alakskvlvs vcshtdpcta scnlipfprp fsnsltrflf clgsarfcis fpcfglsi // LOCUS NP_012889 499 aa linear PLN 30-JUN-2025 DEFINITION UTP glucose-1-phosphate uridylyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012889 VERSION NP_012889.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179601.3 REFERENCE 1 (residues 1 to 499) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 499) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 499) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 499) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09120. On Jul 30, 2012 this sequence version replaced NP_012889.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..499 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..499 /product="UTP glucose-1-phosphate uridylyltransferase" /EC_number="2.7.7.9" /calculated_mol_wt="55857" Region 52..464 /region_name="UDPGP" /note="UTP--glucose-1-phosphate uridylyltransferase; pfam01704" /db_xref="CDD:460300" CDS 1..499 /gene="UGP1" /locus_tag="YKL035W" /coded_by="NM_001179601.3:1..1500" /experiment="EXISTENCE:direct assay:GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity [PMID:40178507]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0070569 uridylyltransferase activity [PMID:22580055]" /experiment="EXISTENCE:genetic interaction:GO:0005978 glycogen biosynthetic process [PMID:9252577]" /experiment="EXISTENCE:genetic interaction:GO:0005992 trehalose biosynthetic process [PMID:9252577]" /experiment="EXISTENCE:genetic interaction:GO:0006011 UDP-alpha-D-glucose metabolic process [PMID:9252577]" /experiment="EXISTENCE:mutant phenotype:GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity [PMID:7588797]" /experiment="EXISTENCE:mutant phenotype:GO:0005978 glycogen biosynthetic process [PMID:9252577]" /experiment="EXISTENCE:mutant phenotype:GO:0006011 UDP-alpha-D-glucose metabolic process [PMID:9252577|PMID:7588797]" /experiment="EXISTENCE:mutant phenotype:GO:0006078 (1->6)-beta-D-glucan biosynthetic process [PMID:17531808]" /note="UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; involved in PKA-mediated oxidative stress resistance and long-term survival in stationary phase; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication" /db_xref="GeneID:853830" /db_xref="SGD:S000001518" ORIGIN 1 mstkkhtkth styafesntn svaasqmrna lnkladsskl ddaarakfen eldsfftlfr 61 rylvekssrt tlewdkiksp npdevvkyei isqqpenvsn lsklavlkln gglgtsmgcv 121 gpksvievre gntfldlsvr qieylnrqyd sdvplllmns fntdkdtehl ikkysanrir 181 irsfnqsrfp rvykdsllpv pteydsplda wyppghgdlf eslhvsgeld aliaqgreil 241 fvsngdnlga tvdlkilnhm ietgaeyime ltdktradvk ggtlisydgq vrllevaqvp 301 kehidefkni rkftnfntnn lwinlkavkr liessnleme iipnqktitr dgheinvlql 361 etacgaairh fdgahgvvvp rsrflpvktc sdlllvksdl frlehgslkl dpsrfgpnpl 421 iklgshfkkv sgfnariphi pkiveldhlt itgnvflgkd vtlrgtviiv csdghkidip 481 ngsilenvvv tgnlqileh // LOCUS NP_012890 758 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein ligase TUL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012890 VERSION NP_012890.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179600.1 REFERENCE 1 (residues 1 to 758) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 758) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 758) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 758) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09121. Method: conceptual translation. FEATURES Location/Qualifiers source 1..758 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..758 /product="ubiquitin-protein ligase TUL1" /EC_number="2.3.2.27" /calculated_mol_wt="87749" Region 320..758 /region_name="COG5540" /note="RING-finger-containing ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]" /db_xref="CDD:227827" CDS 1..758 /gene="TUL1" /locus_tag="YKL034W" /coded_by="NM_001179600.1:1..2277" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:11788821]" /experiment="EXISTENCE:direct assay:GO:0044695 Dsc E3 ubiquitin ligase complex [PMID:22681890]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:11788821]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:11788821]" /experiment="EXISTENCE:mutant phenotype:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:11788821]" /experiment="EXISTENCE:mutant phenotype:GO:0090156 intracellular sphingolipid homeostasis [PMID:31368600]" /experiment="EXISTENCE:mutant phenotype:GO:0140624 EGAD pathway [PMID:31368600]" /note="Subunit of the DSC ubiquitin ligase complex; golgi-localized RING-finger ubiquitin ligase (E3) involved in sorting polar transmembrane domain containing membrane proteins to multivesicular bodies for delivery to the vacuole; involved in the endosome and Golgi-associated degradation pathway (EGAD), contributing to proteostasis and lipid homeostasis; proposed involvement in the quality control of misfolded TMD containing proteins; ortholog of fission yeast dsc1" /db_xref="GeneID:853832" /db_xref="SGD:S000001517" ORIGIN 1 meidgntlvf iivilflffs spggdgvssq yefnqlqrlk qqfrtehntf vnmtytdsfr 61 nitglklsyq dmlnnplqna typlpgkdyd rwfpnqnymv lpndvieain tevwntsndd 121 asnlfppnit stllgkidlv snnkyekirm pvprfyepat dfsedippeg etywsewpsy 181 gelhnvsfqh geiaiqishm snlqdnnnyl rrnfinkknd rwkllnlqid fsdkaekekh 241 siyskavydi qrgrilsisq sskfhslfal phymsfqndy nekifndvke lvdefwnftd 301 ytdvmtmkdv qdaynnanfk ceyliflqle pwnqytrdqi kliddelnwp lgrpanlssl 361 ppinvvsgll yspdcgvrlg lhnvkgtrye lkimsirkhl lfgialfaaq iyllltqmhh 421 tntpsmvnki sfycfsminl vdgslatlyf vaasvvpely lplvisafsc filasifeir 481 ylisiyasqv neqnvgiinl lrgntgtyde nrprpafipd egsiggslyg rfffmliift 541 flilsstswp rqlrmvfeyi lifilnsywi pqifrnavkg ipsrrerars siggnrsqnk 601 mpllwsfvig ttiirslpvv yvftyssnvf rhhkdvhfvv flslwllfqi silysqdvlg 661 srwflpkhti pdgysyfkpl sneyisehgg gtaehtvdca icmsdvpiyi eeipethkvd 721 qhsymvtpcn hvfhtsclen wmnyklqcpv crsplppl // LOCUS NP_012891 236 aa linear PLN 30-JUN-2025 DEFINITION haloacid dehalogenase superfamily protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012891 VERSION NP_012891.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184335.3 REFERENCE 1 (residues 1 to 236) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 236) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 236) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 236) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09122. On Jul 30, 2012 this sequence version replaced NP_012891.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..236 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..236 /product="haloacid dehalogenase superfamily protein" /EC_number="3.1.3.96" /calculated_mol_wt="26039" Region 7..202 /region_name="HAD_AtGPP-like" /note="subfamily of beta-phosphoglucomutase-like family, similar to Arabidopsis thaliana Gpp1 and Gpp2; cd07529" /db_xref="CDD:319831" Site order(13..17,113..114,151,181..182,185..186) /site_type="active" /db_xref="CDD:319831" CDS 1..236 /locus_tag="YKL033W-A" /coded_by="NM_001184335.3:1..711" /experiment="EXISTENCE:direct assay:GO:0008253 5'-nucleotidase activity [PMID:26071590]" /experiment="EXISTENCE:direct assay:GO:1990738 pseudouridine 5'-phosphatase activity [PMID:26071590]" /note="hypothetical protein; similar to uncharacterized proteins from other fungi" /db_xref="GeneID:853833" /db_xref="SGD:S000007242" ORIGIN 1 mthpvavkac lfdmdgllin tediytetln etlaefgkgp ltwdvkiklq glpgpeagkr 61 viehyklpit ldeydernva lqslkwgtce flpgalnllk ylklknipia lctssnktkf 121 rgktshleeg fdlfdtivtg ddpriakgrg kpfpdiwqlg lkelnekfht dikpdecivf 181 edgipgvksa kafgahviwv phpeahavlg dteallagkg ellsslekle mskygl // LOCUS NP_012892 1038 aa linear PLN 30-JUN-2025 DEFINITION Tti1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012892 VERSION NP_012892.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179599.1 REFERENCE 1 (residues 1 to 1038) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1038) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1038) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1038) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1038) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1038) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1038) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09123. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1038 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1038 /product="Tti1p" /calculated_mol_wt="118758" CDS 1..1038 /gene="TTI1" /locus_tag="YKL033W" /coded_by="NM_001179599.1:1..3117" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0110078 TTT Hsp90 cochaperone complex [PMID:19040720]" /note="Subunit of the TTT complex and regulator of telomere length; subunit of the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; detected in mitochondria and the cytoplasm in high-throughput studies; similar to S. pombe Tti1p" /db_xref="GeneID:853834" /db_xref="SGD:S000001516" ORIGIN 1 mnsdtnafkd iriscvelsr iaflptesfd pnsltllacl kkveeklsay eddslspkfa 61 dyvfvpiasl lkqpalgesq teyvlliifh llrtcwssng kfseqlgqql fplitflvss 121 dkdnqklitr sdefkyagcl vlhqffksvr sqryhkeffs nskpnllpal ghsvtillki 181 leqspqnnel qfkalaslev lfqdiisdge mlsfilpgnv svfakiltkp grqihykvcv 241 rtlevlakll vlvyddfsld ikvnkltdir elsdtklkhe inqsfmfngp ivllrtdgkt 301 hrdtswltat sgqinialea fipkllkrnn esidealatf vsilltrcen slnncekvlv 361 stlvhlerdp msklpshlvk lkevvnedlh klsdiirfen adrlsslsfa itileknner 421 dtminevvrc lfeslnesie ppslinhker iieqssqltt tvnfenlest nalialprls 481 edmslklkkf tyhmgsllle rhilndvvte liseqvdspr tqkivalwls tnfikamekq 541 pkeeevylqf esdanysssm veevclivle fcnelsqdis meiegkgikk sdefavctvl 601 fsieticavm reefqpelid yiytvvdala spseairyvs qscalriadt lyhgsipnmi 661 lsnvdylves issrlnsgmt ervsqilmvi cqlagyetie nfkdvietif klldyyhgys 721 dlclqffqlf kiiilemkkk yinddemilk ianqhisqst fspwgmtdfq qvlnildket 781 qvkdditden dvdflkddne psnfqeyfds klrepdsddd eeereeeveg sskeytdqwt 841 spipsdsyki llqilgyger llthpskrlr vqilivmrli fpllstqhnl lirevastwd 901 siiqcvlcsd ysivqpacsc veqmikysgd fvakrfielw qklcqdsfil kelridptvh 961 nhekksiskh vkfppvtena lvsmvhmvle gvkiteylis eavleqiiyc ciqvvpveki 1021 ssmslivgdi vwkirnin // LOCUS NP_012893 597 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcription repressor IXR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012893 VERSION NP_012893.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179598.3 REFERENCE 1 (residues 1 to 597) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 597) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 597) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 597) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 597) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 597) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 597) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09124. On Jul 30, 2012 this sequence version replaced NP_012893.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..597 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..597 /product="DNA-binding transcription repressor IXR1" /calculated_mol_wt="67725" Region <338..501 /region_name="NHP6B" /note="Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]; COG5648" /db_xref="CDD:227935" CDS 1..597 /gene="IXR1" /locus_tag="YKL032C" /gene_synonym="ORD1" /coded_by="NM_001179598.3:1..1794" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:19807692]" /experiment="EXISTENCE:direct assay:GO:0001046 core promoter sequence-specific DNA binding [PMID:29449612]" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:8634251]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:11115121|PMID:19807692]" /experiment="EXISTENCE:genetic interaction:GO:0071456 cellular response to hypoxia [PMID:19807692]" /experiment="EXISTENCE:genetic interaction:GO:2000819 regulation of nucleotide-excision repair [PMID:8538651]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11115121]" /experiment="EXISTENCE:mutant phenotype:GO:0071456 cellular response to hypoxia [PMID:19807692]" /experiment="EXISTENCE:mutant phenotype:GO:0090069 regulation of ribosome biogenesis [PMID:29449612]" /note="Transcriptional repressor that regulates hypoxic genes during normoxia; involved in the aerobic repression of genes such as COX5b, TIR1, and HEM13; binds DNA intrastrand cross-links formed by cisplatin; HMG (high mobility group box) domain containing protein which binds and bends cisplatin-modified DNA, blocking excision repair; IXR1 has a paralog, ABF2, that arose from the whole genome duplication" /db_xref="GeneID:853836" /db_xref="SGD:S000001515" ORIGIN 1 mntgispkqd dasnsnllni gqdhslqyqg lehndsqyrd ashqtphqyl nqfqaqpqqq 61 qqqqqqqqqq qqqapyqghf qqspqqqqqn vyyplppqsl tqptsqsqqq qqqqqqqqya 121 nsnsnsnnnv nvnalpqdfg ymqqtgsgqn yptinqqqfs efynsflshl tqkqtnpsvt 181 gtgassnnns nnnnvssgnn stssnpaqla asqlnpataa aaaannaagp asylsqlpqv 241 qryypnnmna lsslldpssa gnaagnanta thpgllppnl qpqlthhqqq mqqqlqlqqq 301 qqlqqqqqlq qqhqlqqqqq lqqqhhhlqq qqqqqqhpvv kklsstqsri errkqlkkqg 361 pkrpssayfl fsmsirnell qqfpeakvpe lsklasarwk eltddqkkpf yeefrtnwek 421 yrvvrdayek tlppkrpsgp fiqftqeirp tvvkenpdkg lieitkiige rwreldpakk 481 aeytetykkr lkewescypd endpngnptg hshkamnmnl nmdtkimenq dsiehitana 541 idsvtgsnsn stnpntpvsp pislqqqplq qqqqqqqqqq hmlladpttn gsiikne // LOCUS NP_012896 669 aa linear PLN 30-JUN-2025 DEFINITION malate dehydrogenase (oxaloacetate-decarboxylating) [Saccharomyces cerevisiae S288C]. ACCESSION NP_012896 VERSION NP_012896.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179595.1 REFERENCE 1 (residues 1 to 669) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 669) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 669) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 669) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09125. Method: conceptual translation. FEATURES Location/Qualifiers source 1..669 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..669 /product="malate dehydrogenase (oxaloacetate-decarboxylating)" /EC_number="1.1.1.38" /calculated_mol_wt="74245" Region 91..658 /region_name="PRK13529" /note="oxaloacetate-decarboxylating malate dehydrogenase" /db_xref="CDD:237414" CDS 1..669 /gene="MAE1" /locus_tag="YKL029C" /coded_by="NM_001179595.1:1..2010" /experiment="EXISTENCE:direct assay:GO:0004470 malic enzyme activity [PMID:9603875]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:9603875]" /experiment="EXISTENCE:mutant phenotype:GO:0006090 pyruvate metabolic process [PMID:9603875]" /experiment="EXISTENCE:mutant phenotype:GO:0006520 amino acid metabolic process [PMID:9603875]" /note="Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids" /db_xref="GeneID:853839" /db_xref="SGD:S000001512" ORIGIN 1 mlrtrlsvsv aarsqltrsl tasrtaplrr wpiqqsrlys sntrshkatt trentfqkpy 61 sdeevtktpv gsrarkifea phphatrltv egaiecples fqllnsplfn kgsaftqeer 121 eafnleallp pqvntldeql ersykqlcyl ktplakndfm tslrvqnkvl yfalirrhik 181 elvpiiytpt egdaiaaysh rfrkpegvfl ditepdsiec rlatyggdkd vdyivvsdse 241 gilgigdqgi ggvriaiskl almtlcggih pgrvlpvcld vgtnnkklar delymgnkfs 301 rirgkqyddf lekfikavkk vypsavlhfe dfgvknarrl lekyryelps fnddiqgtga 361 vvmasliaal khtnrdlkdt rvliygagsa glgiadqivn hmvthgvdke earkkiflmd 421 rrglilqsye anstpaqhvy aksdaewagi ntrslhdvve nvkptclvgc stqagaftqd 481 vveemhkhnp rpiifplsnp trlheavpad lmkwtnnnal vatgspfppv dgyrisennn 541 cysfpgiglg avlsrattit dkmisaavdq laelsplreg dsrpgllpgl dtitntsarl 601 atavilqale egtarieqeq vpggapgetv kvprdfdecl qwvkaqmwep vyrpmikvqh 661 dpsvhtnql // LOCUS NP_012897 482 aa linear PLN 30-JUN-2025 DEFINITION transcription factor TFIIE subunit TFA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012897 VERSION NP_012897.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179594.3 REFERENCE 1 (residues 1 to 482) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 482) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 482) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 482) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09126. On Jul 30, 2012 this sequence version replaced NP_012897.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..482 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..482 /product="transcription factor TFIIE subunit TFA1" /calculated_mol_wt="54611" Region 23..170 /region_name="TFIIE" /note="Transcription initiation factor IIE; smart00531" /db_xref="CDD:128804" CDS 1..482 /gene="TFA1" /locus_tag="YKL028W" /coded_by="NM_001179594.3:1..1449" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:8702741]" /experiment="EXISTENCE:direct assay:GO:0001097 TFIIH-class transcription factor complex binding [PMID:8702741]" /experiment="EXISTENCE:direct assay:GO:0001113 transcription open complex formation at RNA polymerase II promoter [PMID:10973956]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:9271406]" /experiment="EXISTENCE:direct assay:GO:0005673 transcription factor TFIIE complex [PMID:1429681|PMID:7961670]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:1429681|PMID:7961670|PMID:1331084]" /experiment="EXISTENCE:direct assay:GO:0097550 transcription preinitiation complex [PMID:22751016]" /experiment="EXISTENCE:genetic interaction:GO:0001113 transcription open complex formation at RNA polymerase II promoter [PMID:10973956]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:9271406|PMID:9188494]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:11779853]" /note="TFIIE large subunit; involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening" /db_xref="GeneID:853840" /db_xref="SGD:S000001511" ORIGIN 1 mdrpiddivk nllkfvvrgf yggsfvlvld ailfhsvlae ddlkqllsin ktelgpliar 61 lrsdrlisih kqreyppnsk svervyyyvk yphaidaikw kvhqvvqrlk ddldknsepn 121 gymcpicltk ytqleavqll nfdrteflcs lcdeplvedd sgkknkekqd klnrlmdqiq 181 piidslkkid dsrieentfe ialarlippq nqshaaytyn pkkgstmfrp gdsaplpnlm 241 gtalgndssr ragansqatl hinittasde vaqrelqerq aeekrkqnav pewhkqstig 301 ktalgrldne eefdpvvtas amdsinpdne paqetsyqnn rtlteqemee renektlndy 361 yaalakkqak lnkeeeeeee eeedeeeeee eemedvmddn detarenale defedvtdta 421 gtaktesnts ndvkqesind ktedavnata tasgpsanak pndgdddddd dddemdiefe 481 dv // LOCUS NP_012898 447 aa linear PLN 30-JUN-2025 DEFINITION tRNA threonylcarbamoyladenosine dehydratase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012898 VERSION NP_012898.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179593.1 REFERENCE 1 (residues 1 to 447) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 447) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 447) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 447) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09127. Method: conceptual translation. FEATURES Location/Qualifiers source 1..447 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..447 /product="tRNA threonylcarbamoyladenosine dehydratase" /calculated_mol_wt="50135" Region 76..314 /region_name="YgdL_like" /note="Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; cd00755" /db_xref="CDD:238384" Site order(93,95,97,117,119,128,141,186,192) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:238384" Site order(97,193,211..212,218) /site_type="other" /note="putative substrate interface [chemical binding]" /db_xref="CDD:238384" CDS 1..447 /gene="TCD2" /locus_tag="YKL027W" /coded_by="NM_001179593.1:1..1344" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0061503 tRNA threonylcarbamoyladenosine dehydratase [PMID:23242255]" /experiment="EXISTENCE:mutant phenotype:GO:0061504 cyclic threonylcarbamoyladenosine biosynthetic process [PMID:23242255]" /note="tRNA threonylcarbamoyladenosine dehydratase; required for the ct6A tRNA base modification, where an adenosine at position 37 is modified to form a cyclized active ester with an oxazolone ring; localized to the mitochondrial outer membrane; TCD2 has a paralog, TCD1, that arose from the whole genome duplication" /db_xref="GeneID:853841" /db_xref="SGD:S000001510" ORIGIN 1 mvekdtwkli tatalftvav ttitdyawts wqaqkqviaq qknknkggqt ksdtdkyhqy 61 deqfirqslk nnveflgedt ieklsnqyvv vvgaggvgsw vvnslvrsgc rkirvvdfdq 121 vslsslnrhs cailndvgtp kveclrrhmr eiapwceidp inelwtlqng erltlgngtp 181 dfivdcidni dtkvdllefa ynhgikviss mgasaksdpt klnvgdlatt eedplarvvr 241 rklkkrgils gipvvfsaek pdpkkakllp lpdeeyergk vdelsalkdf rvrilpvlgt 301 mpslfgltit twilsnisdk plepvegknr ikvydgiyqs lagqmsrvgi psqriplalk 361 dvsylveevf kgkspisgis trltltkwdp skpislqnvv vltkneqkvh edrvlkgkes 421 lqdvydakvl klvsqrfree ayysqfr // LOCUS NP_012899 167 aa linear PLN 30-JUN-2025 DEFINITION glutathione peroxidase GPX1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012899 VERSION NP_012899.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179592.3 REFERENCE 1 (residues 1 to 167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 167) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09128. On Jul 30, 2012 this sequence version replaced NP_012899.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..167 /product="glutathione peroxidase GPX1" /EC_number="1.11.1.9" /EC_number="1.11.1.24" /calculated_mol_wt="19353" Region 4..155 /region_name="GSH_Peroxidase" /note="Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; cd00340" /db_xref="CDD:238207" Site order(36,70,125) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:238207" Site order(69,72,74,77,80,84) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238207" CDS 1..167 /gene="GPX1" /locus_tag="YKL026C" /coded_by="NM_001179592.3:1..504" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:22659048]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity [PMID:11445588]" /experiment="EXISTENCE:mutant phenotype:GO:0004602 glutathione peroxidase activity [PMID:10480913]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:22659048]" /experiment="EXISTENCE:mutant phenotype:GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity [PMID:11445588]" /note="Phospholipid hydroperoxide glutathione peroxidase; induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress; glutathione peroxidase activity is neuroprotective in models of Huntington's disease; GPX1 has a paralog, HYR1, that arose from the whole genome duplication" /db_xref="GeneID:853842" /db_xref="SGD:S000001509" ORIGIN 1 mqefysfspi dengnpfpfn slrnkvvliv nvashcaftp qykeleylye kykshglviv 61 afpcgqfgnq efekdkeink fcqdkygvtf pilhkircng qkqdpvykfl knsvsgksgi 121 kmikwnfekf vvdrngkvvk rfscmtrple lcpiieelln qppeeqi // LOCUS NP_012900 679 aa linear PLN 30-JUN-2025 DEFINITION PAN-complex poly(A)-binding subunit PAN3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012900 VERSION NP_012900.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179591.1 REFERENCE 1 (residues 1 to 679) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 679) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 679) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 679) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09129. Method: conceptual translation. FEATURES Location/Qualifiers source 1..679 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..679 /product="PAN-complex poly(A)-binding subunit PAN3" /calculated_mol_wt="76324" Region 311..>419 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Region 540..675 /region_name="Pan3_PK" /note="Pan3 Pseudokinase domain; pfam18101" /db_xref="CDD:465649" CDS 1..679 /gene="PAN3" /locus_tag="YKL025C" /gene_synonym="ECM35" /coded_by="NM_001179591.1:1..2040" /experiment="EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:8816488]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:24872509]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:11953437]" /experiment="EXISTENCE:direct assay:GO:0008143 poly(A) binding [PMID:24872509]" /experiment="EXISTENCE:direct assay:GO:0031251 PAN complex [PMID:8816488]" /experiment="EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:11953437]" /experiment="EXISTENCE:mutant phenotype:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:8816488]" /experiment="EXISTENCE:mutant phenotype:GO:0003723 RNA binding [PMID:24872509]" /experiment="EXISTENCE:mutant phenotype:GO:0008143 poly(A) binding [PMID:24872509]" /experiment="EXISTENCE:physical interaction:GO:0006301 postreplication repair [PMID:11953437]" /note="Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex; poly (A) mRNA binding subunit which recruits mRNA to the complex; the Pan2p-Pan3p complex controls poly(A) tail length and regulates the stoichiometry and activity of postreplication repair complexes" /db_xref="GeneID:853843" /db_xref="SGD:S000001508" ORIGIN 1 mdkinpdwak dipcrnitiy gyckkekegc pfkhsdntta ttindvpppi dvgeattptm 61 tsvpkfnakv sasftpmtvg sdslttvtnt tsaatnatgn iamaatsata stvnpminpi 121 vnsslvnnnn nnsnisisip ttasssnydp fnapiftpss tssihtnana hsfpfpsian 181 sggininatd dnsnnmsman nvpppmqppp iessnlkypr iyppphsllq yhlyapeqps 241 slksllkpne rsadqlfipn niredltkkn lsilqvfpss gkvipsivqd yfnlvplnfn 301 nndflnkttl fkvfsnydgk ayvlkrlpni dksmnpnkis kiyqiwskin ctnlikfrdi 361 fqttkfgdls iclvfdyypn slslydyhfv nfpkfpitnn ylwiylvqlt nvinsihsqn 421 lsigntlnwr kvlitgdpgr iklshcnfmd llfnddtdtv vssggstieg qqqldykylg 481 ellfnlsini ensnnntapk eyrleeitpq siddmrqidd kfkdvlkyli sdngdskksi 541 hdltshfydk mfmvlessqt yteymesvls relengrlfr lvnklncifg riesridinw 601 sesgtkfpii lfydyvfhqv dsngkpimdl thvlrclnkl dagiqeklml vtpdelncii 661 isykelkdli estfrsitq // LOCUS NP_012901 204 aa linear PLN 30-JUN-2025 DEFINITION bifunctional uridylate/adenylate kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012901 VERSION NP_012901.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179590.3 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 204) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09130. On Jul 30, 2012 this sequence version replaced NP_012901.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..204 /product="bifunctional uridylate/adenylate kinase" /EC_number="2.7.4.14" /calculated_mol_wt="22802" Region 18..196 /region_name="UMP_CMP_kin_fam" /note="UMP-CMP kinase family; TIGR01359" /db_xref="CDD:273576" CDS 1..204 /gene="URA6" /locus_tag="YKL024C" /gene_synonym="SOC8" /coded_by="NM_001179590.3:1..615" /experiment="EXISTENCE:direct assay:GO:0004017 AMP kinase activity [PMID:1333436]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8391780]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8391780]" /experiment="EXISTENCE:direct assay:GO:0006139 nucleobase-containing compound metabolic process [PMID:2549068]" /experiment="EXISTENCE:direct assay:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:8391780]" /experiment="EXISTENCE:direct assay:GO:0033862 UMP kinase activity [PMID:2549068|PMID:1655742]" /experiment="EXISTENCE:genetic interaction:GO:0004017 AMP kinase activity [PMID:1333436]" /experiment="EXISTENCE:mutant phenotype:GO:0033862 UMP kinase activity [PMID:1655742]" /note="Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)" /db_xref="GeneID:853844" /db_xref="SGD:S000001507" ORIGIN 1 mtaattsqpa fspdqvsvif vlggpgagkg tqceklvkdy sfvhlsagdl lraeqgrags 61 qygeliknci kegqivpqei tlallrnais dnvkankhkf lidgfprkmd qaisferdiv 121 eskfilffdc pedimlerll ergktsgrsd dniesikkrf ntfketsmpv ieyfetkskv 181 vrvrcdrsve dvykdvqdai rdsl // LOCUS NP_001032581 75 aa linear PLN 30-JUN-2025 DEFINITION Min9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032581 VERSION NP_001032581.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184683.1 REFERENCE 1 (residues 1 to 75) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 75) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 75) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 75) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09131. Method: conceptual translation. FEATURES Location/Qualifiers source 1..75 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..75 /product="Min9p" /calculated_mol_wt="8388" CDS 1..75 /gene="MIN9" /locus_tag="YKL023C-A" /coded_by="NM_001184683.1:1..228" /note="Mitochondrial hypothetical protein" /db_xref="GeneID:3799976" /db_xref="SGD:S000113559" ORIGIN 1 mnpryrfilr fysskkptfh ntapsktnvn vpranksqsk gkhkgkllvl vgtlalvtsv 61 isvnyqknep vefle // LOCUS NP_012902 277 aa linear PLN 30-JUN-2025 DEFINITION Ska1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012902 VERSION NP_012902.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179589.4 REFERENCE 1 (residues 1 to 277) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 277) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 277) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 277) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09132. On Jul 30, 2012 this sequence version replaced NP_012902.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..277 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..277 /product="Ska1p" /calculated_mol_wt="32162" CDS 1..277 /gene="SKA1" /locus_tag="YKL023W" /coded_by="NM_001179589.4:1..834" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:31304628]" /note="SKI complex-associated protein; involved in 3'-5' degradation of long 3'UTR-containing mRNA, poorly translated mRNA, and other RNA regions devoid of ribosomes; proposed to assist the cytoplasmic exosome in a Ska1-SKI complex when a direct interaction between the ribosome and the SKI complex is absent" /db_xref="GeneID:853845" /db_xref="SGD:S000001506" ORIGIN 1 mnkeellgfl lddsidsqkr cvtdqqaysn wlkndndert aheesssqst iaalnkkkqt 61 eaaqedieel lnglegiigg adprnlksks krktkkggsk preenvntek hivmlevedf 121 sdmsthedvn gaspspnldr skknekrrkn akelsydelk dklevttrks rleckdlkkk 181 vhglerrnle leqrleelki enqtlieinn kllkntnede inksqrnkek drkrrerrta 241 rrkderkqek kqekkqdnkt sqsfpsstdm ngqpief // LOCUS NP_012903 840 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit CDC16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012903 VERSION NP_012903.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179588.1 REFERENCE 1 (residues 1 to 840) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 840) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 840) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 840) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09133. Method: conceptual translation. FEATURES Location/Qualifiers source 1..840 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..840 /product="anaphase promoting complex subunit CDC16" /calculated_mol_wt="94862" Region 242..322 /region_name="ANAPC3" /note="Anaphase-promoting complex, cyclosome, subunit 3; pfam12895" /db_xref="CDD:463743" Site order(271..272,274,297,300..301,304..305,307..308,328, 363..364,367..368,371) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 295..322 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 327..386 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 361..389 /region_name="TPR_2" /note="Tetratricopeptide repeat; pfam07719" /db_xref="CDD:429619" Site order(503,506..507,509,532,535..536,539..540,542..543,566, 569..570,573..574,577) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 530..560 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 531..753 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 565..591 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 598..628 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 633..665 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(678..679,682..683,685,709,712..713,716..717,719..720, 743,746..747,750..751) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 678..702 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 707..737 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..840 /gene="CDC16" /locus_tag="YKL022C" /coded_by="NM_001179588.1:1..2523" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:direct assay:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:8895471]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0032297 negative regulation of DNA-templated DNA replication initiation [PMID:9660930]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29883473]" /note="Subunit of the anaphase-promoting complex/cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:853846" /db_xref="SGD:S000001505" ORIGIN 1 mkfclycchc yivicgkath yyksskatsn lkssnrvlmr npmspseqhs qhnstlaasp 61 fvsnvsaart qqslptdaqn drlqqpwnrt ntatspyqsl anspliqklq animtphqps 121 ansnsnsnsi tgnvvndnnl lasmsknsmf gstipstlrk vslqreykds vdgvvrdedn 181 dedvhnngda aananndres klghngpltt ttltttttat qldvselsai erlrlwrfda 241 lmqhmyrtae yiadkvynis ndpddafwlg qvyynnnqyv ravelitrnn ldgvnilcry 301 llglsfvklq rfddaldvig eynpfsedps ttaantmsnn gnnsntsqpv tdggikmess 361 lcflrgkiyf aqnnfnkard afreailvdi knfeafemll sknlltpqee wdlfdsldfk 421 efgedkeimk nlykinlsky inteditksn eilakdykla dnvdvvrskv dicytqckfn 481 eclelcetvl endefntnil payigclyel snknklflls hrlaetfpks aitwfsvaty 541 ymsldrisea qkyyskssil dpsfaaawlg fahtyalege qdqaltayst asrffpgmhl 601 pklflgmqfm amnslnlaes yfvlaydicp ndplvlnemg vmyfkknefv kakkylkkal 661 evvkdldpss rttisiqlnl ghtyrklnen eiaikcfrcv lekndknsei hcslgylylk 721 tkklqkaidh lhkslylkpn nssatallkn alelnvtlsl dashplidks nlmsqaskdk 781 aslnkkrssl tydpvnmakr lrtqkeifdq nnkalrkggh dsktgsnnad ddfdadmele // LOCUS NP_012904 468 aa linear PLN 30-JUN-2025 DEFINITION Mak11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012904 VERSION NP_012904.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179587.3 REFERENCE 1 (residues 1 to 468) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 468) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 468) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 468) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09134. On Jul 30, 2012 this sequence version replaced NP_012904.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..468 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..468 /product="Mak11p" /calculated_mol_wt="53541" Region <98..394 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 109..144 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 150..201 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 206..242 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 251..286 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 293..351 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 359..385 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..468 /gene="MAK11" /locus_tag="YKL021C" /coded_by="NM_001179587.3:1..1407" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:2826479]" /experiment="EXISTENCE:genetic interaction:GO:0000027 ribosomal large subunit assembly [PMID:17308036]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:17308036]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17308036]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:17308036]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:7739558]" /experiment="EXISTENCE:physical interaction:GO:0000027 ribosomal large subunit assembly [PMID:17308036]" /note="Protein involved in an early step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats" /db_xref="GeneID:853847" /db_xref="SGD:S000001504" ORIGIN 1 mllnttytvf iffllriikf kikaenfleh eklkthgtss rkdpkgqvkn scrkmsaigd 61 knqfriivgs yehnilclsl dipnqkenda aktphfmpif hfqahslsik clavsrrylv 121 sgsndehiri ydlqkrkelg tllshqgsit alqfshpass sedaavskgs knskwllsas 181 edhkimvwrv kdwetvgtlk ghtarvndvd ihptnriais vsddhsirlw nlmtlrnaav 241 lklrkyntng tcvrwlgakg dyfavglrdr vliyetgsak vfkeivfqrk tlmhiethil 301 pfdnkeylsv gisdgnvhfy pceelfekve enekqedddd kedispafsl lghtnrikdf 361 kfytnefgty lvtigsdgki vvwdmstkeq vavydcgerl ncltlcdesi ekyntmkkrd 421 aetadigdqs evesdteelk kimfgekkkl nkkkrkqlkk skvsvele // LOCUS NP_012905 1082 aa linear PLN 30-JUN-2025 DEFINITION Spt23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012905 VERSION NP_012905.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179586.1 REFERENCE 1 (residues 1 to 1082) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1082) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1082) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1082) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1082) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1082) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1082) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09135. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1082 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1082 /product="Spt23p" /calculated_mol_wt="121207" Region 508..578 /region_name="IPT" /note="Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; cd00102" /db_xref="CDD:238050" Region 598..>779 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 709..740 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 742..767 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..1082 /gene="SPT23" /locus_tag="YKL020C" /coded_by="NM_001179586.1:1..3249" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11007476]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11007476]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11063674]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9927444]" /experiment="EXISTENCE:genetic interaction:GO:0070417 cellular response to cold [PMID:11855848]" /experiment="EXISTENCE:genetic interaction:GO:2001280 positive regulation of unsaturated fatty acid biosynthetic process [PMID:9927444]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11557770]" /note="ER membrane protein involved in regulation of OLE1 transcription; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting; SPT23 has a paralog, MGA2, that arose from the whole genome duplication" /db_xref="GeneID:853848" /db_xref="SGD:S000001503" ORIGIN 1 mmsgtgnvss mlhsysaniq hndgspdldl leselldial lnsgsslqdp gllslnqekm 61 itagtttpgk edegelrddi aslqglldrh vqfgrklplr tpyanpldfi ninpqslpls 121 leiiglpkvs rvetqmklsf rirnaharkn ffihlpsdci akdkfftssd dptnltipnr 181 dinertlfld afllcasnnn snnfkqtyvc nrcinrekrr asrrksglnd nsiwqnnenk 241 raiifnskql fiisnnglsg nsncinfdlp trivcycrhh katngfvvlf llrdhngdil 301 aktitdpimi mdkknasntt tptstsnaqv spmtndtrsf sspqsdlnfp sefplpsnsk 361 nfvistncml dsncnnnnnd ndnknniktn tammnnnrhf pspnssseds nhsfsdihfs 421 nnndnnlhrs ldswsstgfn sssnpalttl tsdfsaasar htgkrqrsvn epfmstpntf 481 srlpqkfids skdisnhnsv pvalnnkpsi qrvipaqgsi nggievtllg skfkqgliik 541 fgenialssq cwnestmvty lppsskpgpv lvtivdpset smrnnsnssv stsnstndil 601 hlnkytgeka iftyvddtdr qlielalqiv glkmngkled arniakrivg sdsspsnnna 661 glhsqnssln sytnmmrnin deqlitevik sfkrnnnlst vnlsmcdvrg rtllhlaafn 721 nwyslvslli kygshlndqd lfgftplhma cingdlriir lllecnvnim kktrngfiak 781 qfflmnytvn ktrysnyets lfddiltrlt knttgssdtq pfernvsqss fnsslfdddd 841 adhdyvqerk ylladsaala peqsncndnt sfsildsdsg ydisdcesss deialeffnt 901 hkikdfsskp neipkttkts iepdgslwnr mltrlndelp kyedlfpkkp knwelgsksv 961 eigpdnsaqm tvddsqtsse ddelealqvg fntifskkqn fqndkmllff wipltlvlll 1021 cftlsnlgkd ddmfhnlski vqeylrigla kvllgnermk tsfkmqlskf qnnnilndmr 1081 vn // LOCUS NP_012906 316 aa linear PLN 30-JUN-2025 DEFINITION bifunctional protein farnesyltransferase/protein geranylgeranyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012906 VERSION NP_012906.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179585.3 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 316) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09136. On Jul 30, 2012 this sequence version replaced NP_012906.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..316 /product="bifunctional protein farnesyltransferase/protein geranylgeranyltransferase" /EC_number="2.5.1.58" /EC_number="2.5.1.59" /calculated_mol_wt="37377" Region 1..316 /region_name="BET4" /note="Protein prenyltransferase, alpha subunit [Posttranslational modification, protein turnover, chaperones]; COG5536" /db_xref="CDD:227823" CDS 1..316 /gene="RAM2" /locus_tag="YKL019W" /coded_by="NM_001179585.3:1..951" /experiment="EXISTENCE:direct assay:GO:0004660 protein farnesyltransferase activity [PMID:1763050]" /experiment="EXISTENCE:direct assay:GO:0004661 protein geranylgeranyltransferase activity [PMID:2034682]" /experiment="EXISTENCE:direct assay:GO:0004662 CAAX-protein geranylgeranyltransferase activity [PMID:1400380]" /experiment="EXISTENCE:direct assay:GO:0005953 CAAX-protein geranylgeranyltransferase complex [PMID:1400380]" /experiment="EXISTENCE:direct assay:GO:0005965 protein farnesyltransferase complex [PMID:1763050]" /experiment="EXISTENCE:direct assay:GO:0007323 peptide pheromone maturation [PMID:1763050]" /experiment="EXISTENCE:direct assay:GO:0018343 protein farnesylation [PMID:1763050]" /experiment="EXISTENCE:direct assay:GO:0018344 protein geranylgeranylation [PMID:1400380]" /note="Alpha subunit of farnesyltransferase and geranylgeranyltransferase-I; farnesyltransferase (Ram2p-Ram1p heterodimer) catalyzes the addition of 15-carbon isoprenoid farnesyl to substrate proteins containing a CAAX consensus motif; type I geranylgeranyltransferase (Ram2p-Cdc43p heterodimer) catalyzes the addition of the 20-carbon isoprenoid geranylgeranyl to substrate proteins containing a CaaL consensus motif; required for membrane localization of Ras proteins and a-factor" /db_xref="GeneID:853849" /db_xref="SGD:S000001502" ORIGIN 1 meeydysdvk plpietdlqd elcrimyted ykrlmglara lislnelspr alqltaeiid 61 vapafytiwn yrfnivrhmm sesedtvlyl nkeldwldev tlnnpknyqi wsyrqsllkl 121 hpspsfkrel pilklmiddd sknyhvwsyr kwcclffsdf qhelayasdl ietdiynnsa 181 wthrmfywvn akdviskvel adelqfimdk iqlvpqnisp wtylrgfqel fhdrlqwdsk 241 vvdfattfig dvlslpigsp edlpeiessy aleflayhwg adpctrdnav kaysllaiky 301 dpirknlwhh kinnln // LOCUS NP_076899 99 aa linear PLN 30-JUN-2025 DEFINITION Mco12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_076899 VERSION NP_076899.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184481.1 REFERENCE 1 (residues 1 to 99) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 99) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 99) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 99) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09137. Method: conceptual translation. FEATURES Location/Qualifiers source 1..99 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..99 /product="Mco12p" /calculated_mol_wt="11680" Region 4..66 /region_name="DUF1748" /note="Fungal protein of unknown function (DUF1748); pfam08520" /db_xref="CDD:430050" CDS 1..99 /gene="MCO12" /locus_tag="YKL018C-A" /coded_by="NM_001184481.1:1..300" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative mitochondrial hypothetical protein; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:853850" /db_xref="SGD:S000007615" ORIGIN 1 mlgmirwvve gtlvamllsa irretgmiff ynqyqlggwi hrylswgemc ytrtlkmvkr 61 skffrkqlne dgfgrindsg pkrrgrdqsq yssrfveld // LOCUS NP_012907 329 aa linear PLN 30-JUN-2025 DEFINITION WD-repeat containing protein SWD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012907 VERSION NP_012907.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179584.3 REFERENCE 1 (residues 1 to 329) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 329) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 329) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 329) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09138. On Jul 30, 2012 this sequence version replaced NP_012907.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..329 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..329 /product="WD-repeat containing protein SWD2" /calculated_mol_wt="36991" Region <28..322 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 30..72 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 78..111 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 116..152 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 157..197 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 204..240 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 247..294 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..329 /gene="SWD2" /locus_tag="YKL018W" /gene_synonym="CPS35; SAF37" /coded_by="NM_001179584.3:1..990" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11742990|PMID:11805083]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:15146080]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:15146080]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:15146080]" /experiment="EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11752412|PMID:11687631|PMID:11742990]" /note="Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination" /db_xref="GeneID:853851" /db_xref="SGD:S000001501" ORIGIN 1 mttvsinkpn llkfkhvksf qpqekdcgpv tslnfddngq flltsssndt mqlysatnck 61 fldtiaskky gchsaiftha qneciysstm knfdikylnl etnqylryfs ghgalvndlk 121 mnpvndtfls ssydesvrlw dlkiskpqvi ipslvpncia ydpsglvfal gnpenfeigl 181 ynlkkiqegp fliikindat fsqwnklefs nngkyllvgs sigkhlifda ftgqqlfeli 241 gtrafpmref ldsgsacftp dgefvlgtdy dgriaiwnhs dsisnkvlrp qgfipcvshe 301 tcprsiafnp kysmfvtade tvdfyvyde // LOCUS NP_012908 683 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent 5'-3' DNA helicase HCS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012908 VERSION NP_012908.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179583.1 REFERENCE 1 (residues 1 to 683) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 683) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 683) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 683) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09139. Method: conceptual translation. FEATURES Location/Qualifiers source 1..683 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..683 /product="ATP-dependent 5'-3' DNA helicase HCS1" /EC_number="3.6.4.12" /calculated_mol_wt="78142" Region 15..679 /region_name="TIGR00376" /note="DNA helicase, putative" /db_xref="CDD:273041" CDS 1..683 /gene="HCS1" /locus_tag="YKL017C" /gene_synonym="DIP1" /coded_by="NM_001179583.1:1..2052" /experiment="EXISTENCE:direct assay:GO:0033203 DNA helicase A complex [PMID:9341218]" /experiment="EXISTENCE:direct assay:GO:0043139 5'-3' DNA helicase activity [PMID:9341218|PMID:8257676]" /experiment="EXISTENCE:direct assay:GO:0043601 nuclear replisome [PMID:8257676]" /experiment="EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:20463880]" /experiment="EXISTENCE:mutant phenotype:GO:0006301 postreplication repair [PMID:20463880]" /note="Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities" /db_xref="GeneID:853852" /db_xref="SGD:S000001500" ORIGIN 1 mnkelaskfl ssikhereqd iqttsrlltt lsiqqlvqng lainnihlen irsgligkly 61 melgpnlavn dkiqrgdikv gdivlvrpak tkvntktkpk vkkvsedsng eqaecsgvvy 121 kmsdtqitia leesqdviat tfysysklyi lkttnvvtyn rmestmrkls eisspiqdki 181 iqylvnerpf ipntnsfqni ksflnpnlnd sqktainfai nndltiihgp pgtgktftli 241 eliqqllikn peerilicgp snisvdtile rltplvpnnl llrighparl ldsnkrhsld 301 ilskkntivk disqeidkli qenkklknyk qrkenwneik llrkdlkkre fktikdliiq 361 srivvttlhg sssrelcsly rddpnfqlfd tliidevsqa mepqcwipli ahqnqfhklv 421 lagdnkqlpp tikteddknv ihnlettlfd riikifpkrd mvkflnvqyr mnqkimefps 481 hsmyngklla datvanrlli dlptvdatps eddddtkipl iwydtqgdef qetadeatil 541 gskynegeia ivkehienlr sfnvpensig vispynaqvs hlkklihdel kltdieistv 601 dgfqgrekdv iilslvrsne kfevgflkee rrlnvamtrp rrqlvvvgni evlqrcgnky 661 lkswsewcee nadvrypnid dyl // LOCUS NP_012909 174 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit d [Saccharomyces cerevisiae S288C]. ACCESSION NP_012909 VERSION NP_012909.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179582.3 REFERENCE 1 (residues 1 to 174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 174) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09140. On Jul 30, 2012 this sequence version replaced NP_012909.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..174 /product="F1F0 ATP synthase subunit d" /calculated_mol_wt="19678" Region 5..145 /region_name="Mt_ATP-synt_D" /note="ATP synthase D chain, mitochondrial (ATP5H); pfam05873" /db_xref="CDD:461764" CDS 1..174 /gene="ATP7" /locus_tag="YKL016C" /coded_by="NM_001179582.3:1..525" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0045259 proton-transporting ATP synthase complex [PMID:18937496]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:1832157]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:1832157]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:1832157]" /note="Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis" /db_xref="GeneID:853853" /db_xref="SGD:S000001499" ORIGIN 1 mslaksaank ldwakvissl ritgstatql ssfkkrndea rrqllelqsq ptevdfshyr 61 svlkntsvid kiesyvkqyk pvkidaskql qviesfekha mtnaketesl vskelkdlqs 121 tldniqsarp fdeltvddlt kikpeidakv eemvkkgkwd vpgykdrfgn lnvm // LOCUS NP_012910 979 aa linear PLN 30-JUN-2025 DEFINITION Put3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012910 VERSION NP_012910.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179581.1 REFERENCE 1 (residues 1 to 979) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 979) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 979) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 979) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 979) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 979) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 979) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09141. Method: conceptual translation. FEATURES Location/Qualifiers source 1..979 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..979 /product="Put3p" /calculated_mol_wt="111284" Site order(29,33,38..41,43,46,55) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Region 32..68 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(34,37,44,50,53,60) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 70..100 /region_name="ZIP_Put3" /note="Leucine zipper Dimerization domain of transcription factor Put3; cd14651" /db_xref="CDD:271236" Site order(70..73,75..76,79..80,82..83,86..87,89..90,93..94, 97..98,100) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:271236" Site order(70,73,76..77,80) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:271236" Region 73..100 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:271236" Region 335..773 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..979 /gene="PUT3" /locus_tag="YKL015W" /coded_by="NM_001179581.1:1..2940" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:1986247|PMID:8846888]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363|PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:22579222]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8846888]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8846888|PMID:2689862]" /experiment="EXISTENCE:mutant phenotype:GO:2001158 positive regulation of proline catabolic process to glutamate [PMID:2689862]" /note="Transcriptional activator; binds specific gene recruitment sequences and is required for DNA zip code-mediated targeting of genes to nuclear periphery; regulates proline utilization genes, constitutively binds PUT1 and PUT2 promoters as a dimer, undergoes conformational change to form active state; binds other promoters only under activating conditions; differentially phosphorylated in presence of different nitrogen sources; has a Zn(2)-Cys(6) binuclear cluster domain" /db_xref="GeneID:853854" /db_xref="SGD:S000001498" ORIGIN 1 mvtdqgsrhs iqskqpayvn kqpqkrqqrs svaclscrkr hikcpggnpc qkcvtsnaic 61 eylepskkiv vstkylqqlq kdlndkteen nrlkalller pvsvrgkdns ddderhinna 121 pssdtlevss apaapifdlm snsntasdnd ndddnsnrit nnrsydhsle kyykkaisif 181 kqpanangen gnganghedd deddeeistn faqrsgrlie shngfhyfvg sssmtlfgle 241 iqslvtkyis vknfrplpin tknkilnsnl npaissfins nnylfssynf lnpistivnl 301 nsindnlspl mfkiilksdt dgssgqeevi qfqlpsynyt kllidcfiny ndgcfyffne 361 glvkcginkl ylenkwlyyd ntkkaldnen dpilqavwfc killilavge mylgsinnem 421 lknysnqpkl pgskffqmgs kifnclfsse rlenvtkkgg ievlllyaff lqvadytlas 481 yfyfgqalrt clilglhvds qsdtlsryei ehhrrlwwtv ymfermlssk aglplsftdy 541 tistalpadi ddetieekns hyvfrkaeli sncvtivkin aqilsklyqr qpetniiitl 601 kvvikqllew rnnlsdslqv dftqkdedfk isrlstnmft eyfqginlav rpllfhfasi 661 qlkrfktsnt fvnlqnysat isslltcslh asvntirslw sllqnsmlam fsymdreylf 721 tssctlllfn tafgiheqtl yhldhsleif tqmrnlgnip aglrraqllt lmanldfhgi 781 mndlitkynd ilkfdsmnce ndnivedsne pkretekckp hkdgdridps iidcdksntn 841 tnmiknesis nivsilpega kptltdysng nndvndinvn nsepstffdi itaslensyq 901 ttltekgsqv meknmdqlds vhnlndddlq qlledlgnid hsdeklwkei tdqamwlgnt 961 mdptaaagse idftdylgp // LOCUS NP_012911 1764 aa linear PLN 30-JUN-2025 DEFINITION Urb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012911 VERSION NP_012911.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179580.3 REFERENCE 1 (residues 1 to 1764) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1764) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1764) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1764) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09142. On Jul 30, 2012 this sequence version replaced NP_012911.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1764 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1764 /product="Urb1p" /calculated_mol_wt="203157" Region 61..390 /region_name="Npa1" /note="Ribosome 60S biogenesis N-terminal; pfam11707" /db_xref="CDD:463325" Region 1460..1684 /region_name="NopRA1" /note="Nucleolar pre-ribosomal-associated protein 1; pfam16201" /db_xref="CDD:465063" CDS 1..1764 /gene="URB1" /locus_tag="YKL014C" /gene_synonym="NPA1" /coded_by="NM_001179580.3:1..5295" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15208443|PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15208443]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15208443]" /note="Protein required for the normal accumulation of 25S and 5.8S rRNAs; nucleolar protein; associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit" /db_xref="GeneID:853855" /db_xref="SGD:S000001497" ORIGIN 1 msnhseaygs rdqrrekytq gkefedgtle tlesiisave detlskdyqp livffqrgfg 61 aqlvqtwsyy aqvnnhgkfs kttslltktl rvlssdtstv tigsglirli ltdytkvlyr 121 glnnmraqlt npilrllkqi vnfnngqhie elvsyfdfsl pilprllvps kselangnss 181 adsskhdslr ftfikfwltl isnaspfvrk elltenfkim snlfkfmnka dsdklsehil 241 svfindilke ksfkrttktk ilnelaaski hhfyyssnkn lvkkaneffl tfgasrdfsv 301 afpdncvwfk nsvadgashg apitvnqvef qihnkllfnt lrlfkpwedt lqlgtlikil 361 envpelvapy siflttngny dpkmtsywfg itllinkiin lkipqfmekv dsnippatsl 421 vienilpsll tksslvkslq fetpiirqla cqsivlalkk lekvstfydq kgwrnektil 481 lnefhtripd lpifvstlsn slasnkdnri lplsisiifn yyskmfpnlf sinlpssniy 541 tdimqkskis giefaildny lqfqefnstq trwwnpssgg nslftlllkl assknasnvi 601 ttrisnllde ltrtnvifni slispvmalv nslqglslqv seidnmeqvw kwfdetisrv 661 vktpykyvdm akeynyispf imclseqwky vdksgnpefl ikwlilflrn mifigedhig 721 idklvknvfp evsdhdvniy lkldsfeeni kktnssnsli ssmksssffq yisalpsknl 781 mnisrlpvnk ldaagilfrv qllveddsvv ydnwfeatac eltgkiasym vtdtefpiik 841 vleryinfal pklaiekrna llmkksrfmc nligavcfet ghqlvefrei iqkvvfsgen 901 veeyanynel yqkedvnafl tsvseylsts altsllmcst klestrnilq klfnegktik 961 islvknilnk aanedpasik evnislakff eenkvcvdas sdpmgklsls ettslinsfv 1021 ssdlnylvlk afyrwehfsf psfipsiwri kdspllsivt taalfkhmqd kdfsafahet 1081 iskygneiak styttsksei fdeilnmitt yidfydetkr neilkcvlsq sdhkyhaatv 1141 ryiaahnnft ypgvetwlhk tllyltkyls erkvisnsff ellramaell kleevpnkln 1201 vkiinsqlea ilgsewikqi kvleyvivli fcvskksiqs qrmvqlllsn dsyssimikd 1261 ndedssyrkf lstmilfslf sidpvvnstp ivqeklltfy sgtissndkl ilkileties 1321 htatswtnmi fswefikdee eeileaigdt rlitkeregl iltlqknmik ksidryvler 1381 pqvpelytds ntnnydattr cdlvkkyydd tersgvdmyd plflllliih nkelvkmvkd 1441 degnvtyrye fenfldckif qfiicslsdc htvanisyeh lsnlasslek ktaqmnlekq 1501 itskdnerke sdsdlikyns iyqvlikril yqrqqnqdpi npliwfsisr ivdllgspta 1561 plhekayrwv lsnstirswd ipmvsdvmms ynkrqqddnk keidmeiyyg elswvlttic 1621 kgiktdedyk mlekkgvfew llnlinmpyl kerlreliyf ifykvqrvad dgglnlisrn 1681 givsffevln nniksrlpqd dilnnigtlr nenrgtlntt lrlaqeqngi eklllgynel 1741 vksqkrlilw tegdsdnvvk rlrk // LOCUS NP_012912 171 aa linear PLN 30-JUN-2025 DEFINITION Arc19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012912 VERSION NP_012912.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179579.1 REFERENCE 1 (residues 1 to 171) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 171) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 171) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 171) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09143. Method: conceptual translation. FEATURES Location/Qualifiers source 1..171 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..171 /product="Arc19p" /calculated_mol_wt="19785" Region 1..166 /region_name="ARPC4" /note="ARP2/3 complex 20 kDa subunit (ARPC4); pfam05856" /db_xref="CDD:461760" CDS 1..171 /gene="ARC19" /locus_tag="YKL013C" /coded_by="NM_001179579.1:1..516" /experiment="EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:9210376|PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:10377407]" /note="Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; mutation is functionally complemented by human ARPC4" /db_xref="GeneID:853856" /db_xref="SGD:S000001496" ORIGIN 1 msqslrpylt avrysleaal tlsnfssqev erhnrpevev pntsaelllq pmhisrnene 61 qvliepsvns vrmslmvkqa deieqilvhk ftrfleqrae afyilrrvpi pgysisflit 121 nkhtesmktg klvdfiiefm edvdkeisei klflnararf vaeayldefv y // LOCUS NP_012913 583 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-splicing protein PRP40 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012913 VERSION NP_012913.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179578.3 REFERENCE 1 (residues 1 to 583) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 583) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 583) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 583) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09144. On Jul 30, 2012 this sequence version replaced NP_012913.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..583 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..583 /product="snoRNA-splicing protein PRP40" /calculated_mol_wt="68934" Region 1..583 /region_name="PRP40" /note="Splicing factor [RNA processing and modification]; COG5104" /db_xref="CDD:227435" CDS 1..583 /gene="PRP40" /locus_tag="YKL012W" /coded_by="NM_001179578.3:1..1752" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:8622699]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8622699]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:15020406]" /note="U1 snRNP protein involved in splicing; interacts with the branchpoint-binding protein during the formation of the second commitment complex" /db_xref="GeneID:853857" /db_xref="SGD:S000001495" ORIGIN 1 msiwkeakda sgriyyyntl tkkstwekpk elisqeelll rengwkaakt adgkvyyynp 61 ttretswtip afekkvepia eqkhdtvsha qvngnrialt agekqepgrt ineeesqyan 121 nskllnvrrr tkeeaekefi tmlkenqvds twsfsriise lgtrdprywm vdddplwkke 181 mfekylsnrs adqllkehne tskfkeafqk mlqnnshiky ytrwptakrl iadepiykhs 241 vvnektkrqt fqdyidtlid tqkeskkklk tqalkelrey lngiittsss etfitwqqll 301 nhyvfdkskr ymanrhfkvl thedvlneyl kivntiendl qnklnelrlr nytrdriard 361 nfksllrevp ikikantrws diyphiksdp rflhmlgrng sscldlfldf vdeqrmyifa 421 qrsiaqqtli dqnfewndad sdeitkqnie kvlendrkfd kvdkedisli vdglikqrne 481 kiqqklqner rileqkkhyf wlllqrtytk tgkpkpstwd laskelgesl eykalgdedn 541 irrqifedfk pessaptaes atanltltas kkrhltpave ldy // LOCUS NP_012914 353 aa linear PLN 30-JUN-2025 DEFINITION cruciform cutting endonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_012914 VERSION NP_012914.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179577.1 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 353) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09145. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..353 /product="cruciform cutting endonuclease" /EC_number="3.1.21.10" /calculated_mol_wt="40869" Region 22..318 /region_name="CCE1" /note="fungal mitochondrial Holliday junction resolvases similar to Saccharomyces cerevisiae CCE1; cd16963" /db_xref="CDD:438563" Site order(75..77,102,105,120,147..149,151,153,160,163..164,201, 291) /site_type="other" /note="putative nucleic acid substrate binding site [nucleotide binding]" /db_xref="CDD:438563" Site order(118..119,122,126,161,165..166,168..170,172..174, 176..177) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:438563" CDS 1..353 /gene="CCE1" /locus_tag="YKL011C" /gene_synonym="MGT1" /coded_by="NM_001179577.1:1..1062" /experiment="EXISTENCE:direct assay:GO:0004520 DNA endonuclease activity [PMID:8413191]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8413191]" /experiment="EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:12198175]" /note="Mitochondrial cruciform cutting endonuclease; cleaves Holliday junctions formed during recombination of mitochondrial DNA; CCE1 has a paralog, MRS1, that arose from the whole genome duplication" /db_xref="GeneID:853858" /db_xref="SGD:S000001494" ORIGIN 1 mstaqkakil qlidsccqna kstqlkslsf vigavngttk eakrtyiqeq cefleklrqq 61 kiregrinil smdagvsnfa fskmqllnnd plpkvldwqk inleekffqn lkklslnpae 121 tselvfnlte ylfesmpipd mftierqrtr tmssrhildp ilkvnileqi lfsnlenkmk 181 ytnkipntsk lrymvcssdp hrmtsywcip reetptsskk lksnkhskds riklvkkils 241 tsilegnsts stklvefigv wnnrirnalt kkksfklcdi leiqdnsgvr kdddladsfl 301 hclswmewlk nyesitelln sktlvktqfg qvfefcenkv qklkflqnty nnd // LOCUS NP_012915 1483 aa linear PLN 30-JUN-2025 DEFINITION putative ubiquitin-protein ligase UFD4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012915 VERSION NP_012915.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179576.3 REFERENCE 1 (residues 1 to 1483) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1483) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1483) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1483) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09146. On Jul 30, 2012 this sequence version replaced NP_012915.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1483 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1483 /product="putative ubiquitin-protein ligase UFD4" /EC_number="2.3.2.26" /calculated_mol_wt="167713" Region 581..1482 /region_name="HUL4" /note="Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]; COG5021" /db_xref="CDD:227354" CDS 1..1483 /gene="UFD4" /locus_tag="YKL010C" /coded_by="NM_001179576.3:1..4452" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0035519 protein K29-linked ubiquitination [PMID:28165462]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:10089879]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10089879]" /experiment="EXISTENCE:mutant phenotype:GO:0010994 free ubiquitin chain polymerization [PMID:22497224]" /experiment="EXISTENCE:physical interaction:GO:1904855 proteasome regulatory particle binding [PMID:12447385|PMID:10688918]" /note="Ubiquitin-protein ligase (E3); interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; involved in K29-linked ubiquitin-dependent protein catabolism, including ubiquitin fusion proteins; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:853859" /db_xref="SGD:S000001493" ORIGIN 1 msennshnld eheshsensd ymmdtqvedd ydedghvqge ysyypdeded ehmlssvgsf 61 eaddgedddn dyhheddsgl lygyhrtqng sdedrneeed glershdnne fgsnplhlpd 121 iletfaqrle qrrqtseglg qhpvgrtlpe ilsmiggrme rsaessarne risklientg 181 nasedpyiam eslkelseni lmmnqmvvdr iipmetlign iaailsdkil reelelqmqa 241 crcmynlfev cpesisiavd ehvipilqgk lveisyidla eqvletveyi srvhgrdilk 301 tgqlsiyvqf fdfltihaqr kaiaivsnac ssirtddfkt ivevlptlkp ifsnatdqpi 361 ltrlvnamyg icgalhgvdk fetlfsldli erivqlvsiq dtplenklkc ldiltvlams 421 sdvlsrelre ktdivdmatr sfqhyskspn aglhetliyv pnsllisisr fivvlfpped 481 erilsadkyt gnsdrgvisn qekfdslvqc lipilveiyt naadfdvrry vliallrvvs 541 cinnstakai ndqlikligs ilaqketasn angtysseag tllvgglsll dlickkfsel 601 ffpsikregi fdlvkdlsvd fnnidlkedg nenislsdee gdlhssieec degdeeydye 661 ftdmeipdsv kpkkisihif rtlslayikn kgvnlvnrvl sqmnveqeai teelhqiegv 721 vsilenpstp dkteedwkgi wsvlkkcifh edfdvsgfef tstglassit kritsstvsh 781 filaksflev fedcidrfle ilqsaltrle nfsivdcglh dgggvsslak eikiklvydg 841 daskdnigtd lsstivsvhc iasftslnef lrhrmvrmrf lnslipnlts ssteadreee 901 encldhmrkk nfdffydnek vdmestvfgv ifntfvrrnr dlktlwddth tikfcksleg 961 nnreseaaee anegkklrdf ykkrefaqvd tgssadiltl ldflhscgvk sdsfinskls 1021 aklarqldep lvvasgalpd wslfltrrfp flfpfdtrml flqctsfgyg rliqlwknks 1081 kgskdlrnde alqqlgritr rklrisrkti fatglkilsk ygsspdvlei eyqeeagtgl 1141 gptlefysvv skyfarksln mwrcnsysyr semdvdttdd yittllfpep lnpfsnnekv 1201 ielfgylgtf varslldnri ldfrfskvff ellhrmstpn vttvpsdvet cllmielvdp 1261 llakslkyiv ankddnmtle slsltftvpg nddielipgg cnkslnssnv eeyihgvidq 1321 ilgkgiekql kafiegfskv fsyermlilf pdelvdifgr veedwsmatl ytnlnaehgy 1381 tmdssiihdf isiisafgkh errlflqflt gspklpiggf kslnpkftvv lkhaedglta 1441 deylpsvmtc anylklpkyt skdimrsrlc qaieegagaf lls // LOCUS NP_012916 236 aa linear PLN 30-JUN-2025 DEFINITION ribosome assembly factor MRT4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012916 VERSION NP_012916.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179575.1 REFERENCE 1 (residues 1 to 236) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 236) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 236) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 236) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09147. Method: conceptual translation. FEATURES Location/Qualifiers source 1..236 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..236 /product="ribosome assembly factor MRT4" /calculated_mol_wt="26927" Region 21..196 /region_name="Ribosomal_P0_like" /note="Ribosomal protein L10 family, P0-like protein subfamily; composed of uncharacterized eukaryotic proteins with similarity to the 60S ribosomal protein P0, including the Saccharomyces cerevisiae protein called mRNA turnover protein 4 (MRT4). MRT4 may be...; cd05796" /db_xref="CDD:240222" Site order(23..24,27,69..72,75) /site_type="other" /note="23S rRNA interface [nucleotide binding]" /db_xref="CDD:240222" Site order(110,130,134,164,168..169,172..173,175..178,181..183, 186..187,189..190,192) /site_type="other" /note="putative Interface with L7/L12 ribosomal proteins [polypeptide binding]" /db_xref="CDD:240222" CDS 1..236 /gene="MRT4" /locus_tag="YKL009W" /coded_by="NM_001179575.1:1..711" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:19797079]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19797079|PMID:19797078|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:11583614|PMID:23212245]" /experiment="EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:19797079]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:19797079]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:10471698]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12837249]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]" /note="Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus" /db_xref="GeneID:853860" /db_xref="SGD:S000001492" ORIGIN 1 mprskrsklv tlaqtdkkgr enkerifdev realdtyryv wvlhlddvrt pvlqeirtsw 61 agsklimgkr kvlqkalgek reeeykenly qlsklcsgvt gllftdedvn tvkeyfksyv 121 rsdysrpntk apltftipeg ivysrggqip aeedvpmihs leptmrnkfe iptkikagki 181 tidspylvct egekldvrqa lilkqfgiaa sefkvkvsay ydndsstves tninme // LOCUS NP_012917 418 aa linear PLN 30-JUN-2025 DEFINITION sphingosine N-acyltransferase LAC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012917 VERSION NP_012917.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179574.3 REFERENCE 1 (residues 1 to 418) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 418) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 418) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 418) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09148. On Jul 30, 2012 this sequence version replaced NP_012917.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..418 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..418 /product="sphingosine N-acyltransferase LAC1" /EC_number="2.3.1.297" /calculated_mol_wt="48861" Region 9..389 /region_name="LAG1" /note="Protein transporter of the TRAM (translocating chain-associating membrane) superfamily, longevity assurance factor [Intracellular trafficking and secretion]; COG5058" /db_xref="CDD:227391" CDS 1..418 /gene="LAC1" /locus_tag="YKL008C" /gene_synonym="DGT1" /coded_by="NM_001179574.3:1..1257" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10198056]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0046513 ceramide biosynthetic process [PMID:15692566]" /experiment="EXISTENCE:direct assay:GO:0050291 sphingosine N-acyltransferase activity [PMID:15692566]" /experiment="EXISTENCE:direct assay:GO:0061576 acyl-CoA ceramide synthase complex [PMID:15692566]" /experiment="EXISTENCE:mutant phenotype:GO:0046513 ceramide biosynthetic process [PMID:11694577]" /experiment="EXISTENCE:mutant phenotype:GO:0050291 sphingosine N-acyltransferase activity [PMID:11387200|PMID:11694577]" /note="Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p; LAC1 has a paralog, LAG1, that arose from the whole genome duplication" /db_xref="GeneID:853861" /db_xref="SGD:S000001491" ORIGIN 1 mstikpspsn nnlkvrsrpr rkssigkidl gdtvpslgtm fetkesktaa krrmqrlsea 61 tkndsdlvkk iwfsfreisy rhawiaplmi liavysayft sgnttktnvl hrfvavsyqi 121 gdtnaygkgi ndlcfvfyym ifftflrefl mdvvirpfai rlhvtskhri krimeqmyai 181 fytgvsgpfg iycmyhsdlw ffntkamyrt ypdftnpflf kvfylgqaaf waqqacilvl 241 qlekprkdhn eltfhhivtl lliwssyvfh ftkmglpiyi tmdvsdflls fsktlnylds 301 glaffsfaif vvawiylrhy inlkilwsvl tqfrtegnyv lnfatqqykc wislpivfvl 361 igalqlvnly wlflifrvly rilwrgilkd drsdsesdee sdessttptd stptkkdi // LOCUS NP_012918 268 aa linear PLN 30-JUN-2025 DEFINITION Cap1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012918 VERSION NP_012918.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179573.1 REFERENCE 1 (residues 1 to 268) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 268) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 268) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 268) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09149. Method: conceptual translation. FEATURES Location/Qualifiers source 1..268 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..268 /product="Cap1p" /calculated_mol_wt="30568" Region 10..263 /region_name="F-actin_cap_A" /note="F-actin capping protein alpha subunit; pfam01267" /db_xref="CDD:460142" CDS 1..268 /gene="CAP1" /locus_tag="YKL007W" /coded_by="NM_001179573.1:1..807" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:1315784]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922|PMID:1315784]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008290 F-actin capping protein complex [PMID:14769858]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:38088874|PMID:14769858]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051016 barbed-end actin filament capping [PMID:14769858|PMID:1315784]" /experiment="EXISTENCE:direct assay:GO:0110085 mitotic actomyosin contractile ring [PMID:38088874]" /experiment="EXISTENCE:mutant phenotype:GO:0008290 F-actin capping protein complex [PMID:14769858]" /experiment="EXISTENCE:mutant phenotype:GO:0051015 actin filament binding [PMID:14769858]" /note="Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress" /db_xref="GeneID:853862" /db_xref="SGD:S000001490" ORIGIN 1 mssskfeevi nkiindsppg elrevyddli kitsensknt ildaienynv qncipievng 61 nsviiskynk egakffdpvn svifsvnhle rkgldiepye fthakiekgq lkelhdklhe 121 yllqsfpgdv sfavypvpee iskisiiivs tkynpnnfwn ghwrssyiyd letrelsgqi 181 stqvhyyedg nvsfqsgkdi nqsnvddvvc tirdietnfe ndldlsffdl nekqfkalrr 241 rlpvtrskin wgsaigsyrl gknaaegk // LOCUS NP_012919 97 aa linear PLN 30-JUN-2025 DEFINITION Sft1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012919 VERSION NP_012919.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001180028.3 REFERENCE 1 (residues 1 to 97) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 97) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 97) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 97) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 97) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09150. On Jul 30, 2012 this sequence version replaced NP_012919.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..97 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..97 /product="Sft1p" /calculated_mol_wt="10829" Region 10..68 /region_name="SNARE_Bet1" /note="SNARE motif of Bet1; cd15853" /db_xref="CDD:277206" Site order(14..17,19..21,23..25,27..28,30..35,37..38,40..41, 44..45,47..49,51..53,55..56,58..59,62..63,65..66,68) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277206" Site 41 /site_type="other" /note="zero layer" /db_xref="CDD:277206" CDS 1..97 /gene="SFT1" /locus_tag="YKL006C-A" /coded_by="NM_001180028.3:1..294" /experiment="EXISTENCE:direct assay:GO:0000138 Golgi trans cisterna [PMID:7596416]" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11959998]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11959998]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11959998]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:10591633|PMID:7596416]" /note="Intra-Golgi v-SNARE; required for transport of proteins between an early and a later Golgi compartment" /db_xref="GeneID:853863" /db_xref="SGD:S000002101" ORIGIN 1 msnsrysqte snndrklegl anklatfrni nqeigdravs dssvinqmtd slgsmftdik 61 nsssrltrsl kagnsiwrmv glalliffil ytlfklf // LOCUS NP_012920 138 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL14 RPL14A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012920 VERSION NP_012920.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179572.1 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 138) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09151. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..138 /product="60S ribosomal protein eL14 RPL14A" /calculated_mol_wt="15036" Region 13..131 /region_name="eL14" /note="Vairimorpha necatrix ribosomal protein eL14 and similar proteins; cd23702" /db_xref="CDD:467915" Region 55..128 /region_name="Ribosomal_L14e" /note="Ribosomal protein L14; pfam01929" /db_xref="CDD:460388" CDS 1..138 /gene="RPL14A" /locus_tag="YKL006W" /coded_by="NM_001179572.1:1..417" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:29788267]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:29788267]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:29788267]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /note="Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication" /db_xref="GeneID:853864" /db_xref="SGD:S000001489" ORIGIN 1 mstdsivkas nwrlvevgrv vlikkgqsag klaaiveiid qkkvlidgpk agvprqainl 61 gqvvltpltf alprgartat vskkwaaaav cekwaasswa kkiaqrerra altdferfqv 121 mvlrkqkryt vkkalaka // LOCUS NP_012921 594 aa linear PLN 30-JUN-2025 DEFINITION Bye1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012921 VERSION NP_012921.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179571.3 REFERENCE 1 (residues 1 to 594) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 594) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 594) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 594) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09152. On Jul 30, 2012 this sequence version replaced NP_012921.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..594 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..594 /product="Bye1p" /calculated_mol_wt="67770" Region 74..131 /region_name="PHD_Bye1p_SIZ1_like" /note="PHD domain found in Saccharomyces cerevisiae bypass of ESS1 protein 1 (Bye1p), the E3 Sumo Ligase SIZ1, and similar proteins; cd15570" /db_xref="CDD:277045" Site order(74,93..97,101,126) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:277045" Region 235..354 /region_name="TFS2M" /note="Domain in the central regions of transcription elongation factor S-II (and elsewhere); smart00510" /db_xref="CDD:128786" Region 436..589 /region_name="SPOC_Bye1p-like" /note="SPOC (Spen paralog and ortholog C-terminal) domain found in Saccharomyces cerevisiae bypass of ESS1 protein 1 (Bye1p) and similar proteins; cd21542" /db_xref="CDD:439205" CDS 1..594 /gene="BYE1" /locus_tag="YKL005C" /coded_by="NM_001179571.3:1..1785" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:14704159]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:24003114]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:17142463]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:14704159]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:14704159]" /note="Negative regulator of transcription elongation; contains a TFIIS-like domain that associates with chromatin and a PHD domain that interacts with H3K4me3; multicopy suppressor of temperature-sensitive ess1 mutations, binds RNA polymerase II large subunit" /db_xref="GeneID:853865" /db_xref="SGD:S000001488" ORIGIN 1 msvrtssrsn kgqnkyieyl lqeeteapkk krtkkkvdsa ieknkksdss qeprkdtenv 61 rtdevdeade gyvrclcgan nenydaaeys hgdmvqcdgc dtwqhikcmt dgkdtidglm 121 sedskyycel cdpslyahle tskeaevsed edyhddvykp vndhddndad vfldeesprk 181 rkrspdsakg ihikskqvkk sngskkrnks idaaksdtae nemptrkdfe sekehklryn 241 aekmfstlfs kfivpetiea klyelpdgkd visisqefah nleeelykac lnvefgtldk 301 iytekvrsly snlkdkknle lkahvvegkl plnklvnmna selanpdlqe fkekrdkiil 361 enfivevpdk pmyvkthkgd eliediaepq edilyskdsi rlhnidsids dkskieqtha 421 iskepspsti ineeslncaf lypglgleft gylnyigasq klrrdifkea igdgklyveg 481 rlptttaapy lkeiscsrai lvyqlfpsnd seskttfadv vdslenkgri agikpktrye 541 kdfyivpskg geipeilkdi lgshnderse rfsrmksder tlfafvvvkq efih // LOCUS NP_012922 401 aa linear PLN 30-JUN-2025 DEFINITION inositol phosphorylceramide synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012922 VERSION NP_012922.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179570.1 REFERENCE 1 (residues 1 to 401) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 401) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 401) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 401) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09153. Method: conceptual translation. FEATURES Location/Qualifiers source 1..401 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..401 /product="inositol phosphorylceramide synthase" /EC_number="2.7.1.227" /calculated_mol_wt="45062" Region 122..317 /region_name="PAP2_Aur1_like" /note="PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; cd03386" /db_xref="CDD:239481" Site order(194,202,253..255,288,294,298) /site_type="active" /db_xref="CDD:239481" CDS 1..401 /gene="AUR1" /locus_tag="YKL004W" /coded_by="NM_001179570.1:1..1206" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:10888667]" /experiment="EXISTENCE:direct assay:GO:0006673 inositol phosphoceramide metabolic process [PMID:19726565]" /experiment="EXISTENCE:direct assay:GO:0045140 inositol phosphoceramide synthase activity [PMID:19047657]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:9092515]" /experiment="EXISTENCE:mutant phenotype:GO:0045140 inositol phosphoceramide synthase activity [PMID:9092515]" /experiment="EXISTENCE:physical interaction:GO:0070916 inositol phosphoceramide synthase complex [PMID:19726565]" /note="Phosphatidylinositol:ceramide phosphoinositol transferase; required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance; also known as IPC synthase" /db_xref="GeneID:853866" /db_xref="SGD:S000001487" ORIGIN 1 manpfsrwfl serppnchva dletsldphq tllkvqkykp alsdwvhyif lgsimlfvfi 61 tnpapwifki lfycflgtlf iipatsqfff nalpiltwva lyftssyfpd drrppitvkv 121 lpavetilyg dnlsdilats tnsfldilaw lpyglfhfga pfvvaailfv fgpptvlqgy 181 afafgymnlf gvimqnvfpa appwykilyg lqsanydmhg spgglaridk llginmytta 241 fsnssvifga fpslhsgcat mealffcycf pklkplfiay vcwlwwstmy lthhyfvdlm 301 agsvlsyvif qytkythlpi vdtslfcrws ytsiekydis ksdplaadsn diesvplsnl 361 eldfdlnmtd epsvspslfd gstsvsrssa tsitslgvkr a // LOCUS NP_012923 131 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein bS6m MRP17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012923 VERSION NP_012923.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179569.3 REFERENCE 1 (residues 1 to 131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 131) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09154. On Jul 30, 2012 this sequence version replaced NP_012923.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..131 /product="mitochondrial 37S ribosomal protein bS6m MRP17" /calculated_mol_wt="14890" Region 2..99 /region_name="bS6_mito" /note="Mitochondrial Ribosomal Protein (MRP) S6; cd15465" /db_xref="CDD:275386" Site order(3,52,56,75,78..79,86,93,96..98) /site_type="other" /note="rRNA binding site [nucleotide binding]" /db_xref="CDD:275386" Site order(4,6,48,50..52,66,68,93,97) /site_type="other" /note="S18 interface [polypeptide binding]" /db_xref="CDD:275386" CDS 1..131 /gene="MRP17" /locus_tag="YKL003C" /gene_synonym="bS6m" /coded_by="NM_001179569.3:1..396" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552|PMID:9151978]" /note="Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator" /db_xref="GeneID:853867" /db_xref="SGD:S000001486" ORIGIN 1 mlyeliglvr itnsnapkle akelsstigk liiqnrgvvr divpmgiryl pkimkkdqek 61 hfrayhflml fdssaavqse ilrtlkkdpr virssivkvd ldkqldrass lhrslgkksi 121 lelvnedyqs i // LOCUS NP_012924 232 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-III subunit protein DID4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012924 VERSION NP_012924.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179568.1 REFERENCE 1 (residues 1 to 232) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 232) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 232) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 232) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09155. On Aug 9, 2000 this sequence version replaced NP_012924.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..232 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..232 /product="ESCRT-III subunit protein DID4" /calculated_mol_wt="26160" Region 20..187 /region_name="Snf7" /note="pfam03357" /db_xref="CDD:460896" CDS 1..232 /gene="DID4" /locus_tag="YKL002W" /gene_synonym="CHM2; GRD7; REN1; VPL2; VPS14; VPS2; VPT14" /coded_by="NM_001179568.1:1..699" /experiment="EXISTENCE:direct assay:GO:0000815 ESCRT III complex [PMID:12194857]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12194857]" /experiment="EXISTENCE:direct assay:GO:0045324 late endosome to vacuole transport [PMID:12194857]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:19234443]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /note="Class E Vps protein of the ESCRT-III complex; required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis" /db_xref="GeneID:853868" /db_xref="SGD:S000001485" ORIGIN 1 mslfewvfgk nvtpqerlkk nqralertqr elerekrkle lqdkklvsei kksakngqva 61 aakvqakdlv rtrnyiqkfd nmkaqlqais lriqavrssd qmtrsmseat gllagmnrtm 121 nlpqlqrism efekqsdlmg qrqefmdeai dnvmgdevde deeadeivnk vldeigvdln 181 sqlqstpqnl vsnapiaeta mgipepigag sefhgnpddd lqarlntlkk qt // LOCUS NP_012925 202 aa linear PLN 30-JUN-2025 DEFINITION adenylyl-sulfate kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012925 VERSION NP_012925.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179567.3 REFERENCE 1 (residues 1 to 202) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 202) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 202) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 202) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09156. On Jul 30, 2012 this sequence version replaced NP_012925.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..202 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..202 /product="adenylyl-sulfate kinase" /EC_number="2.7.1.25" /calculated_mol_wt="22929" Region 7..192 /region_name="apsK" /note="adenylyl-sulfate kinase; TIGR00455" /db_xref="CDD:129547" Site order(33..34,36..39,64,73,78,81,104..106,140,157..158) /site_type="other" /note="ligand-binding site [chemical binding]" /db_xref="CDD:238985" CDS 1..202 /gene="MET14" /locus_tag="YKL001C" /coded_by="NM_001179567.3:1..609" /experiment="EXISTENCE:direct assay:GO:0004020 adenylylsulfate kinase activity [PMID:3019265]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:1101032]" /experiment="EXISTENCE:mutant phenotype:GO:0004020 adenylylsulfate kinase activity [PMID:197388]" /experiment="EXISTENCE:mutant phenotype:GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [PMID:197388]" /note="Adenylylsulfate kinase; required for sulfate assimilation and involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant" /db_xref="GeneID:853869" /db_xref="SGD:S000001484" ORIGIN 1 matnitwhpn ltyderkalr kqdgctiwlt glsasgksti acaleqlllq knlsayrldg 61 dnirfglnkd lgfsekdrne nirrisevsk lfadscaisi tsfispyrvd rdrarelhke 121 aglkfieifv dvplevaeqr dpkglykkar egvikeftgi sapyeapkap elhlrtdqkt 181 veecatiiye ylisekiirk hl // LOCUS NP_012926 704 aa linear PLN 30-JUN-2025 DEFINITION dynamin-like GTPase VPS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012926 VERSION NP_012926.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179791.1 REFERENCE 1 (residues 1 to 704) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 704) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 704) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 704) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09157. Method: conceptual translation. FEATURES Location/Qualifiers source 1..704 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..704 /product="dynamin-like GTPase VPS1" /calculated_mol_wt="78606" Region 27..336 /region_name="DLP_1" /note="Dynamin_like protein family includes dynamins and Mx proteins; cd08771" /db_xref="CDD:206738" Site 36..43 /site_type="other" /note="G1 box" /db_xref="CDD:206738" Site order(37,39..44,57..58,63,178,248,250..251,277..281,284) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206738" Site order(38..39,182,195,220,222,224..227,229..230,251, 253..256,280..282) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:206738" Site 63 /site_type="other" /note="G2 box" /db_xref="CDD:206738" Site 67..69 /site_type="other" /note="Switch I region" /db_xref="CDD:206738" Site 178..181 /site_type="other" /note="G3 box" /db_xref="CDD:206738" Site order(180..181,211..212) /site_type="other" /note="Switch II region" /db_xref="CDD:206738" Site 247..250 /site_type="other" /note="G4 box" /db_xref="CDD:206738" Region 257..541 /region_name="Dynamin_M" /note="Dynamin central region; pfam01031" /db_xref="CDD:460033" Site 277..279 /site_type="other" /note="G5 box" /db_xref="CDD:206738" Region 614..704 /region_name="GED" /note="Dynamin GTPase effector domain; pfam02212" /db_xref="CDD:460495" CDS 1..704 /gene="VPS1" /locus_tag="YKR001C" /gene_synonym="GRD1; LAM1; SPO15; VPL1; VPT26" /coded_by="NM_001179791.1:1..2115" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:15550248]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8299420]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:23385815]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:16520372]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0007031 peroxisome organization [PMID:12707309]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:20841380]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:25772449]" /experiment="EXISTENCE:direct assay:GO:0060988 lipid tube assembly [PMID:20841380]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:20841380]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:37060997]" /experiment="EXISTENCE:mutant phenotype:GO:0000407 phagophore assembly site [PMID:37060997]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8299420]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:26478779|PMID:20841380]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:37060997]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:12707309]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:8299420]" /experiment="EXISTENCE:mutant phenotype:GO:0016559 peroxisome fission [PMID:18445678]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:15265985]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:37060997]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0051017 actin filament bundle assembly [PMID:26478779|PMID:25772449]" /note="Dynamin-like GTPase required for vacuolar sorting; promotes fission of retrograde transport carriers from endosome; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis" /db_xref="GeneID:853870" /db_xref="SGD:S000001709" ORIGIN 1 mdehlistin klqdalaplg ggsqspidlp qitvvgsqss gkssvleniv grdflprgtg 61 ivtrrplvlq linrrpkkse hakvnqtane lidlninddd kkkdesgkhq negqsednke 121 ewgeflhlpg kkfynfdeir keivketdkv tgansgissv pinlriysph vltltlvdlp 181 gltkvpvgdq ppdierqikd mllkyiskpn aiilsvnaan tdlansdglk larevdpegt 241 rtigvltkvd lmdqgtdvid ilagrviplr ygyipvinrg qkdiehkkti realenerkf 301 fenhpsyssk ahycgtpyla kklnsillhh irqtlpeika kieatlkkyq nelinlgpet 361 mdsassvvls mitdfsneya gildgeakel ssqelsggar isyvfhetfk ngvdsldpfd 421 qikdsdirti mynssgsaps lfvgteafev lvkqqirrfe epslrlvtlv fdelvrmlkq 481 iisqpkysry palreaisnq fiqflkdati ptnefvvdii kaeqtyinta hpdllkgsqa 541 mvmveeklhp rqvavdpktg kplptqpsss kapvmeeksg ffggffstkn kkklaalesp 601 ppvlkatgqm teretmetev ikllissyfs ivkrtiadii pkalmlkliv ksktdiqkvl 661 leklygkqdi eeltkendit iqrrkeckkm veilrnasqi vssv // LOCUS NP_012927 568 aa linear PLN 30-JUN-2025 DEFINITION polynucleotide adenylyltransferase PAP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012927 VERSION NP_012927.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179792.3 REFERENCE 1 (residues 1 to 568) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 568) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 568) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 568) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09158. On Jul 30, 2012 this sequence version replaced NP_012927.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..568 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..568 /product="polynucleotide adenylyltransferase PAP1" /EC_number="2.7.7.19" /calculated_mol_wt="64421" Region 8..351 /region_name="PAP_central" /note="Poly(A) polymerase central domain; pfam04928" /db_xref="CDD:461486" Region 353..526 /region_name="PAP_RNA-bind" /note="Poly(A) polymerase predicted RNA binding domain; pfam04926" /db_xref="CDD:461484" CDS 1..568 /gene="PAP1" /locus_tag="YKR002W" /coded_by="NM_001179792.3:1..1707" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0031124 mRNA 3'-end processing [PMID:1840648]" /experiment="EXISTENCE:direct assay:GO:1990817 poly(A) RNA polymerase activity [PMID:1840648]" /experiment="EXISTENCE:genetic interaction:GO:0031126 sno(s)RNA 3'-end processing [PMID:18951092]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:8524265]" /note="Poly(A) polymerase; one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping" /db_xref="GeneID:853871" /db_xref="SGD:S000001710" ORIGIN 1 mssqkvfgit gpvstvgata aenklndsli qelkkegsfe teqetanrvq vlkilqelaq 61 rfvyevskkk nmsdgmarda ggkiftygsy rlgvhgpgsd idtlvvvpkh vtredfftvf 121 dsllrerkel deiapvpdaf vpiikikfsg isidlicarl dqpqvplslt lsdknllrnl 181 dekdlralng trvtdeilel vpkpnvfria lraiklwaqr ravyanifgf pggvawamlv 241 aricqlypna csavilnrff iilsewnwpq pvilkpiedg plqvrvwnpk iyaqdrshrm 301 pvitpaypsm cathnitest kkvilqefvr gvqitndifs nkkswanlfe kndfffrykf 361 yleitaytrg sdeqhlkwsg lveskvrllv mklevlagik iahpftkpfe ssyccptedd 421 yemiqdkygs hktetalnal klvtdenkee esikdapkay lstmyigldf nienkkekvd 481 ihipctefvn lcrsfnedyg dhkvfnlalr fvkgydlpde vfdenekrps kkskrknlda 541 rhetvkrsks daasgdning ttaavdvn // LOCUS NP_012928 448 aa linear PLN 30-JUN-2025 DEFINITION oxysterol-binding protein OSH6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012928 VERSION NP_012928.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179793.1 REFERENCE 1 (residues 1 to 448) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 448) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 448) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 448) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09159. Method: conceptual translation. FEATURES Location/Qualifiers source 1..448 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..448 /product="oxysterol-binding protein OSH6" /calculated_mol_wt="51457" Region 53..393 /region_name="Oxysterol_BP" /note="Oxysterol-binding protein; pfam01237" /db_xref="CDD:460126" CDS 1..448 /gene="OSH6" /locus_tag="YKR003W" /coded_by="NM_001179793.1:1..1347" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16096648]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:16156791]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0043325 phosphatidylinositol-3,4-bisphosphate binding [PMID:16156791]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:16156791]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:16156791]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:16156791]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:29487131]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]" /experiment="EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:16585271]" /experiment="EXISTENCE:genetic interaction:GO:0016125 sterol metabolic process [PMID:16096648]" /experiment="EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]" /experiment="EXISTENCE:mutant phenotype:GO:0055092 sterol homeostasis [PMID:16156791]" /note="Oxysterol-binding phosphatidylserine transferase; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery; overexpression extends lifespan by promoting vacuolar fusion; OSH6 has a paralog, OSH7, that arose from the whole genome duplication" /db_xref="GeneID:853872" /db_xref="SGD:S000001711" ORIGIN 1 mgskkltvgs dshrlskssf ssnksshsat kdqpidtddi deddesghni ilniisqlrp 61 gcdltritlp tfilekksml ervtnqlqfp efllqahsek dplkrflyvm kwylagwhia 121 pkavkkplnp vlgeyftayw dlpnkqqayy iseqtshhpp ecayfymipe ssirvdgvvi 181 pksrflgnss aammdgstvl qfldikdgng kpekyvltqp nvyvrgilfg kmrielgdhm 241 iikspnfqad iefktkgyvf gtydaiegtv kdydgnayye isgkwndvmy lkdlkqprss 301 pkvfldthke splrpkvrpl seqgeyesrk lwkkvtdala vrnhpvatee kfqiedhqrq 361 lakkriedgv efhpklfrrs kpgedldyci yknipvdedp ekqirsilqi apilpgqqft 421 dkffipafek iksqkkmien ekqnpakq // LOCUS NP_012929 377 aa linear PLN 30-JUN-2025 DEFINITION Ecm9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012929 VERSION NP_012929.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179794.3 REFERENCE 1 (residues 1 to 377) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 377) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 377) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 377) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09160. On Jul 30, 2012 this sequence version replaced NP_012929.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..377 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..377 /product="Ecm9p" /calculated_mol_wt="44452" CDS 1..377 /gene="ECM9" /locus_tag="YKR004C" /gene_synonym="YKR004C-A" /coded_by="NM_001179794.3:1..1134" /experiment="EXISTENCE:direct assay:GO:0170069 geranylgeranyltransferase-III complex [PMID:40049413]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:40049413]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:40049413]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:40049413]" /experiment="EXISTENCE:mutant phenotype:GO:0051302 regulation of cell division [PMID:39415825]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:39415825]" /experiment="EXISTENCE:mutant phenotype:GO:0071555 cell wall organization [PMID:39415825]" /experiment="EXISTENCE:mutant phenotype:GO:0170068 geranylgeranyltransferase type III activity [PMID:40049413]" /note="Alpha-subunit of geranylgeranyltransferase type III; required with beta subunit Bet2p to transfer a geranylgeranyl group to mono-farnsylated Ykt6p, regulating membrane localization and its function in cell wall integrity and autophagy; involved in cell wall maintenance; functions in a regulatory pathway determining cell division readiness under stress; null is sensitive to osmotic stress and resistant to calcofluor white; structural and functional homolog of human GGTase-III alpha subunit PTAR1" /db_xref="GeneID:853873" /db_xref="SGD:S000001712" ORIGIN 1 mqsslplcre ffekitayld yhdfrltita nqpsitlpyy vdekahsiel iifkttflsl 61 fqeahtyfnk tfsdqsgisn eniyymtvgf llttpenktv ynvhedllkr yfqdnsvlvi 121 pdllvkevrl iqrllcssnn rinkssslwi lyrklfvlsl dantlvlpdi lfvfhssgsq 181 hfsnyycwnt arwfydnlpy nkrielfnlt krfcfqnvkd csswsalaym vcqqeekktd 241 nirdfqrlts sfnvpfkink vdlnfqvqpa daftqelvkw idrtyaadwp pylcllqitk 301 fnitlriemd svlltwrnei lnfeensghi kminntpivp ekfsndllts vnfahfgykk 361 lflnkfldkn kkeqsds // LOCUS NP_012930 525 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKR005C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012930 VERSION NP_012930.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179795.1 REFERENCE 1 (residues 1 to 525) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 525) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 525) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 525) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09161. On Sep 17, 2007 this sequence version replaced NP_012930.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..525 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..525 /product="uncharacterized protein" /calculated_mol_wt="58579" CDS 1..525 /locus_tag="YKR005C" /coded_by="NM_001179795.1:1..1578" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24390141]" /note="hypothetical protein" /db_xref="GeneID:853874" /db_xref="SGD:S000001713" ORIGIN 1 mleclsallv lfaggggsvl aavqsktvad pnlcpgynsq lispflssck rnlsecvsry 61 fdeqyafcrs cvtvnnetme dldnckclqc alsslnnscf hdyctskdey dklqivveqf 121 qltngvlddg eilkprgnkf ssrklsyfvg qnntlfrnpl qfeknqlisa lltsltnnqk 181 tissvdmfev vdannevqyl rertisgktl spatgyeeen dgdcsvkdkk wegkieyhen 241 kkvssencsk dtddksgskk erntkaplfh tateihmtrw sswrpkkift rylvneyqsp 301 kiittvnrfy rtktdtetgt tlitstkakr rwfprtkivt statstflsi ttttttnaia 361 tkslvavlnp dglnkkagin fglfsangel aspdeggtpt vvrrdkisdp gaaneqatlf 421 sttfsqvphl peldsgefis aasqldkrif iftaitvsit tlmmlgfsyr srvsfrdhsi 481 ddsdddndws ddevefdeey fyslpvsipe kgisldkmaq qlgve // LOCUS NP_012931 264 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL50 MRPL13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012931 VERSION NP_012931.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179796.3 REFERENCE 1 (residues 1 to 264) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 264) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 264) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 264) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09162. On Jul 30, 2012 this sequence version replaced NP_012931.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..264 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..264 /product="mitochondrial 54S ribosomal protein mL50 MRPL13" /calculated_mol_wt="30140" Region 124..229 /region_name="Ribosomal_L50" /note="Ribosomal subunit 39S; pfam10501" /db_xref="CDD:402226" CDS 1..264 /gene="MRPL13" /locus_tag="YKR006C" /gene_synonym="mL50; YK105" /coded_by="NM_001179796.3:1..795" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:2060626]" /note="Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation" /db_xref="GeneID:853875" /db_xref="SGD:S000001714" ORIGIN 1 mssllklhci rplpqrsvwl sgykqkarci hssaangdfm swfkrkkqee hqepvkdtkq 61 likdieegtn eassqsssnn knrlelipen figegsrrck rqkelklavs sapfnqwlsr 121 dkitsdnqld dmilqatekt lgkvdqdvqf sdlvakfqft kflqsksgyl ipdyelttls 181 tplqfkryik ekilpsandp klaykeaepn aihpfsdnya spniyvvndv tskeqkskyd 241 timkeiqkle ddatrkalet arsa // LOCUS NP_012932 184 aa linear PLN 30-JUN-2025 DEFINITION Meh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012932 VERSION NP_012932.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179797.1 REFERENCE 1 (residues 1 to 184) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 184) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 184) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 184) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09163. Method: conceptual translation. FEATURES Location/Qualifiers source 1..184 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..184 /product="Meh1p" /calculated_mol_wt="20111" Region 19..92 /region_name="LAMTOR" /note="Late endosomal/lysosomal adaptor and MAPK and MTOR activator; pfam15454" /db_xref="CDD:464726" CDS 1..184 /gene="MEH1" /locus_tag="YKR007W" /gene_synonym="EGO1; GSE2" /coded_by="NM_001179797.1:1..555" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:15989961|PMID:15885099|PMID:19748353|PMID:16301533|P MID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0031902 late endosome membrane [PMID:16732272]" /experiment="EXISTENCE:direct assay:GO:0071986 Ragulator complex [PMID:16732272]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:15885099]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:15989961]" /experiment="EXISTENCE:mutant phenotype:GO:0072665 protein localization to vacuole [PMID:26206314]" /experiment="EXISTENCE:physical interaction:GO:0071986 Ragulator complex [PMID:15989961]" /note="Subunit of EGO/GSE complex; vacuolar/endosomal membrane-associated EGO/GSE complex regulates exit from rapamycin-induced growth arrest, stimulating microautophagy and sorting of Gap1p from endosome to plasma membrane; targeted to vacuole via AP-3 pathway; loss results in defect in vacuolar acidification" /db_xref="GeneID:853876" /db_xref="SGD:S000001715" ORIGIN 1 mgavlsccrn hsgeeneall reqqagygsq gnandeydae qmrlkehehe qkllareqel 61 rdivantndk lidisminns giviqgtdlq ealdkrqqee ggdsreders agddnlsghs 121 vpssgsaqat thqtaprtnt ftlltspdsa kiskeqlkkl hsnilneifs qsqvnkpgpl 181 tvpf // LOCUS NP_012933 625 aa linear PLN 30-JUN-2025 DEFINITION Rsc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012933 VERSION NP_012933.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179798.4 REFERENCE 1 (residues 1 to 625) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 625) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 625) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 625) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 625) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09164. On Jul 30, 2012 this sequence version replaced NP_012933.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..625 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..625 /product="Rsc4p" /calculated_mol_wt="72160" Region 40..423 /region_name="COG5076" /note="Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]" /db_xref="CDD:227408" CDS 1..625 /gene="RSC4" /locus_tag="YKR008W" /coded_by="NM_001179798.4:1..1878" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019|PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0140006 histone H3 reader activity [PMID:20126658]" /note="Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p" /db_xref="GeneID:853877" /db_xref="SGD:S000001716" ORIGIN 1 mvvkkrklat eaggsderpk ylpgkhpknq ektphvdyna plnpkselfl ddwhipkfnr 61 fisftldvli dkykdifkdf iklpsrkfhp qyyykiqqpm sineiksrdy eyedgpsnfl 121 ldvelltknc qayneydsli vknsmqvvml iefevlkakn lkrnylinse vkakllhyln 181 klvdatekki nqallgassp knlddkvkls epfmelvdkd elpeyyeivh spmalsivkq 241 nleigqyski ydfiidmllv fqnahifndp saliykdatt ltnyfnyliq keffpelqdl 301 nergeinlef dkfefenyla iggggpaaag alaisaldnd iepesnredl idqadydfnh 361 feglgngynr slltedylln pnnfkkliak petvqsevkn ersttsdiek tnslesehlk 421 ipkynviksm qkemqslseq htmeykpykl iqqiyifssk nlysqatkpl lgsrpscnqn 481 wveyifngne lsqnenafsf mlqpmqtflt lqshltsslk dtetlltink epvksrtsnv 541 nsnlsqpqqq endvigndtk qdienltigg gnnndivgnd ndkrnnitei fdirlsegln 601 hlmfrcedki shetefmnfw invlp // LOCUS NP_012934 900 aa linear PLN 30-JUN-2025 DEFINITION bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012934 VERSION NP_012934.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179799.1 REFERENCE 1 (residues 1 to 900) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 900) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 900) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 900) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09165. Method: conceptual translation. FEATURES Location/Qualifiers source 1..900 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..900 /product="bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2" /EC_number="1.1.1.n12" /EC_number="4.2.1.119" /calculated_mol_wt="98572" Region 5..255 /region_name="hydroxyacyl-CoA-like_DH_SDR_c-like" /note="(3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; cd05353" /db_xref="CDD:187611" Site order(5,32,108..110,112..114,117..118,121,125..126,129, 132..133,136..137,153..161,163,166..167,170..171,173..175, 177..179,181..182,184..185,187,210,213..214,218,221..222, 224..226,233,237..239,241..255) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:187611" Site order(16,19..21,39..41,43,75..76,100..103,123..124, 150..152,165,169,195..197,199..202) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:187611" Site order(124,152,165,169) /site_type="active" /db_xref="CDD:187611" Region 336..566 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" Site order(428,456,469,473) /site_type="active" /db_xref="CDD:187611" Region 613..886 /region_name="PLN02864" /note="enoyl-CoA hydratase" /db_xref="CDD:178455" Region 782..894 /region_name="HDE_HSD" /note="HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; cd03448" /db_xref="CDD:239532" Site order(793,796,799..800,804,806,810) /site_type="other" /note="dimer interaction site [polypeptide binding]" /db_xref="CDD:239532" Site order(797,803,805,808,825,827,830,833,837,847,849,851,865, 874,876,885,891) /site_type="active" /note="substrate-binding tunnel [active]" /db_xref="CDD:239532" Site order(798,802..803,805,808,823,826..827) /site_type="active" /db_xref="CDD:239532" Site order(803,805,808,826) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:239532" CDS 1..900 /gene="FOX2" /locus_tag="YKR009C" /gene_synonym="POX2" /coded_by="NM_001179799.1:1..2703" /experiment="EXISTENCE:direct assay:GO:0003857 3-hydroxyacyl-CoA dehydrogenase (NAD+) activity [PMID:1551874]" /experiment="EXISTENCE:direct assay:GO:0004300 enoyl-CoA hydratase activity [PMID:1551874]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:30131444]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:10497229|PMID:1551874]" /note="3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; mutation is functionally complemented by human HSD17B4" /db_xref="GeneID:853878" /db_xref="SGD:S000001717" ORIGIN 1 mpgnlsfkdr vvvitgaggg lgkvyalaya srgakvvvnd lggtlggsgh nskaadlvvd 61 eikkaggiav anydsvneng ekiietaike fgrvdvlinn agilrdvsfa kmterefasv 121 vdvhltggyk lsraawpymr sqkfgriint aspaglfgnf gqanysaakm glvglaetla 181 kegakyninv nsiaplarsr mtenvlpphi lkqlgpekiv plvlylthes tkvsnsifel 241 aagffgqlrw erssgqifnp dpktytpeai lnkwkeitdy rdkpfnktqh pyqlsdyndl 301 itkakklppn eqgsvkiksl cnkvvvvtga ggglgkshai wfarygakvv vndikdpfsv 361 veeinklyge gtaipdshdv vteapliiqt aiskfqrvdi lvnnagilrd ksflkmkdee 421 wfavlkvhlf stfslskavw piftkqksgf iinttstsgi ygnfgqanya aakaailgfs 481 ktialegakr giivnviaph aetamtktif sekelsnhfd asqvsplvvl laseelqkys 541 grrvigqlfe vgggwcgqtr wqrssgyvsi ketiepeeik enwnhitdfs rntinpsste 601 essmatlqav qkahsskeld dglfkyttkd cilynlglgc tskelkytye ndpdfqvlpt 661 favipfmqat atlamdnlvd nfnyamllhg eqyfklctpt mpsngtlktl akplqvldkn 721 gkaalvvggf etydiktkkl iaynegsffi rgahvppeke vrdgkrakfa vqnfevphgk 781 vpdfeaeist nkdqaalyrl sgdfnplhid ptlakavkfp tpilhglctl gisakalfeh 841 ygpyeelkvr ftnvvfpgdt lkvkawkqgs vvvfqtidtt rnvivldnaa vklsqakskl // LOCUS NP_012935 771 aa linear PLN 30-JUN-2025 DEFINITION Tof2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012935 VERSION NP_012935.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179800.3 REFERENCE 1 (residues 1 to 771) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 771) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 771) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 771) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 771) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 771) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 771) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09166. On Jul 30, 2012 this sequence version replaced NP_012935.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..771 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..771 /product="Tof2p" /calculated_mol_wt="86235" Region 83..153 /region_name="Cytokin_check_N" /note="Cdc14 phosphatase binding protein N-terminus; pfam10407" /db_xref="CDD:431263" CDS 1..771 /gene="TOF2" /locus_tag="YKR010C" /coded_by="NM_001179800.3:1..2316" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:18595708]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0019211 phosphatase activator activity [PMID:18595708]" /experiment="EXISTENCE:genetic interaction:GO:0007000 nucleolus organization [PMID:18595708]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:17043313]" /experiment="EXISTENCE:mutant phenotype:GO:0007000 nucleolus organization [PMID:18595708]" /experiment="EXISTENCE:mutant phenotype:GO:0034503 protein localization to nucleolar rDNA repeats [PMID:19362534|PMID:18595708]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:18923139]" /note="Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication" /db_xref="GeneID:853880" /db_xref="SGD:S000001718" ORIGIN 1 mikmwrlqiv lvppsaqdii tflearlntp qsvspmvqyn ediithnnsi nncsdpspts 61 pssqnsiqsn rssdfinylp nckkflhftd gdntllqlsn eiltkfdrly pnfkesieiv 121 slqdrhgcdl dsefiikdvf endgvvlvil kdeldwsrnq hisllqlarq rrrqdnkpst 181 ksivtekrkk iskedlssis nkdtmhliak sslknnfink srvstplmne ilplaskyda 241 lnkekcpmpl tstvvasnvh kdvkdharak egvvtqgsdn nkenipsstq qqkndgakra 301 eskdldllrn ssedadyepa denspqisfd sidtdfqlst tshtnsdmhi qysnpssgah 361 sprkssleik vqnkkgddlp lndkdigenc rrieafsdee dfnetdndra dsfinnskka 421 smgfrdinsd ldsvsfnsdi enavqstqst knvvsppffp ekelnnrlhq sqgkealfrl 481 vekefpdksl gaasstshak dvkiqetirk lnrfkptget kvqkrnsite pyygkfgimk 541 kdkpksitsk gvsletkhfd dpntiisgek fakfgkikvk rktddvgskv iefkrkrnmg 601 nrslkdifan agkppnaast ikvvklmrdp vdnskdkvea tsnstaqeqe qvspklpvmn 661 stpgkrkngq aipsslertp qlkkvkvtrs hsspsssssm slessldsss sddsdddsds 721 rnvqvkkinf ktshgpagns ngkpmldvdd neintkkyqt pkyvesdedd q // LOCUS NP_012936 353 aa linear PLN 30-JUN-2025 DEFINITION chromatin-associated RNAPIII regulator FPT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012936 VERSION NP_012936.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179801.1 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 353) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09167. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..353 /product="chromatin-associated RNAPIII regulator FPT1" /calculated_mol_wt="41169" CDS 1..353 /gene="FPT1" /locus_tag="YKR011C" /coded_by="NM_001179801.1:1..1062" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031669 cellular response to nutrient levels [PMID:37995691]" /experiment="EXISTENCE:direct assay:GO:0071443 tDNA binding [PMID:37995691]" /note="Chromatin-associated negative regulator of RNA polymerase III assembly; differentially and dynamically occupies RNA polymerase III-transcribed genes; promotes eviction of RNAPIII; occupancy depends on TFIIIB and TFIIIC, not RNAPIII; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853881" /db_xref="SGD:S000001719" ORIGIN 1 mskletvyly ageeqprvkl tcikegltlt qvikfvhsiq elygielqts etitenlkid 61 capaylkpnc iphfyileye eisdtffiwk sdgrwqlnkl sallyvdnda nvvkntswke 121 vfqndqrfkn ydkrawlqnc lekmnrdlsk lnveqfwsqy dkicqsiakq kkkqeqfnme 181 vfdnfknivs iaiiktkvls nkrlltttlk nyhnsmkkky niqeqnlken slascsnnep 241 saslesesrh fspvnslsps slstddeavs tdyiykgpes kpnvnfmhss atndliksnf 301 esyfklmaed yetfdlraws rqrprkfqlv ekkkitknpp nshhphkngk isf // LOCUS NP_012938 329 aa linear PLN 30-JUN-2025 DEFINITION sterol-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012938 VERSION NP_012938.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179803.3 REFERENCE 1 (residues 1 to 329) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 329) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 329) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 329) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09168. On Jul 30, 2012 this sequence version replaced NP_012938.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..329 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..329 /product="sterol-binding protein" /calculated_mol_wt="33649" Region 191..319 /region_name="CAP_PRY1-like" /note="CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins; cd05384" /db_xref="CDD:349403" CDS 1..329 /gene="PRY2" /locus_tag="YKR013W" /gene_synonym="YFW12" /coded_by="NM_001179803.3:1..990" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:23027975]" /experiment="EXISTENCE:genetic interaction:GO:0015908 fatty acid transport [PMID:28365570]" /experiment="EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:23027975]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:23027975]" /note="Sterol binding protein involved in the export of acetylated sterols; role in sterol export is redundant with that of PRY1; redundant role with PRY1 and PRY3 in the export of free fatty acids; may be involved in detoxification of hydrophobic compounds; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins)" /db_xref="GeneID:853882" /db_xref="SGD:S000001721" ORIGIN 1 mkfskvslla asasvalsap vavtvtqhvh qaatvvvqgi vrvengqtlt tfitkgtqta 61 saspvattsa pivvanaqvd siatsviqes avvaesatfe esstetseaf statatiqav 121 qtsasatqdd vtttltsstq ptstttpttt ttspttttsp tttaspttta spttatttqs 181 tasstqssss dfstsmvneh ntkralhkdt gsltwsdtla tyaqnyadsy dcsgnlvhsg 241 gpygenlalg ygttgsvdaw yneitsydys npgfsesagh ftqvvwkgts evgcglkscg 301 gewgdyiics ykaagnvige fadnvmpla // LOCUS NP_012939 234 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase YPT52 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012939 VERSION NP_012939.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179804.1 REFERENCE 1 (residues 1 to 234) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 234) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 234) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 234) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09169. Method: conceptual translation. FEATURES Location/Qualifiers source 1..234 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..234 /product="Rab family GTPase YPT52" /calculated_mol_wt="26001" Region 3..194 /region_name="Rab5_related" /note="Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion; cd01860" /db_xref="CDD:206653" Site 3..5 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206653" Site 10..17 /site_type="other" /note="G1 box" /db_xref="CDD:206653" Site order(12..18,28..29,34..35,69,125..126,128,175..177) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206653" Site order(18..29,33..34) /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206653" Site order(28,33..41) /site_type="other" /note="Switch I region" /db_xref="CDD:206653" Site order(33,37..44,59,61) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206653" Site 35 /site_type="other" /note="G2 box" /db_xref="CDD:206653" Site order(36..37,39,65..66,73,75,77..79) /site_type="other" /note="putative GDI interaction site [polypeptide binding]" /db_xref="CDD:206653" Site 36..40 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206653" Site order(38..40,42,72,79..80) /site_type="active" /note="effector interaction site [active]" /db_xref="CDD:206653" Site 61..65 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206653" Site 66..69 /site_type="other" /note="G3 box" /db_xref="CDD:206653" Site order(69,71..81) /site_type="other" /note="Switch II region" /db_xref="CDD:206653" Site 72..77 /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206653" Site 80..81 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206653" Site 89..94 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206653" Site 117..122 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206653" Site 125..128 /site_type="other" /note="G4 box" /db_xref="CDD:206653" Site 175..177 /site_type="other" /note="G5 box" /db_xref="CDD:206653" Site 191..193 /site_type="other" /note="Rab subfamily motif 4 (RabSF4)" /db_xref="CDD:206653" CDS 1..234 /gene="YPT52" /locus_tag="YKR014C" /coded_by="NM_001179804.1:1..705" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:23612966|PMID:22748138]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:22748138]" /experiment="EXISTENCE:genetic interaction:GO:0036010 protein localization to endosome [PMID:23264632]" /experiment="EXISTENCE:genetic interaction:GO:0036258 multivesicular body assembly [PMID:22748138]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:8163546]" /experiment="EXISTENCE:mutant phenotype:GO:0005770 late endosome [PMID:11872141]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8163546]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:22748138]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8163546]" /note="Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853884" /db_xref="SGD:S000001722" ORIGIN 1 mlqfklvllg dssvgkssiv hrfvkdtfde lrestigaaf lsqsitihpn dgnetkdvvi 61 kfeiwdtagq erykslapmy yrnanaalvv yditqedslq karnwvdelk nkvgdddlvi 121 yllgnkvdlc qetpstetsp dsneggdeeq kvraisteea kqyaqeqgll frevsaktge 181 gvkeifqdig eklydlkkde ilskqnrqig ggnngqvdin lqrpstndpt sccs // LOCUS NP_012940 568 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKR015C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012940 VERSION NP_012940.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179805.3 REFERENCE 1 (residues 1 to 568) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 568) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 568) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 568) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 568) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09170. On Jul 30, 2012 this sequence version replaced NP_012940.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..568 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..568 /product="uncharacterized protein" /calculated_mol_wt="66453" CDS 1..568 /locus_tag="YKR015C" /coded_by="NM_001179805.3:1..1707" /note="hypothetical protein" /db_xref="GeneID:853885" /db_xref="SGD:S000001723" ORIGIN 1 mfldysgyea lteinssfgk yvlllqqfeg crslkdrlqm lkdlgrefmi fenlnvedfr 61 esknmihrfy tmvislrqim eigplvrrsp avlvvefdcp vedcldeldp lhplnrafif 121 ihkqwtyyhq yyivekvkkv ildmapvked dwsilhkvvy segfverryk kkkylgdiyi 181 pqplmksnki ttisnfsqlt kisnvrvyrf nataacdpqn lnkknlsike lkdkdlpnli 241 wtlepekfyv dmrpykehee rkkrreeeak vrmqgeeqen imierkkmds ieveassglk 301 niiktplanr vvntfnncaa vvigyvtevd kvkddneekn ndrpkiandg iaqksrsese 361 dnagtpmena yfqpepqdnd qnniswnttm kdidpiymse rcarvwrkeq qmlglekaqt 421 fekkyckdqm vmdenqveep gkhserhtkn qvvrprtkia ssaskndnsn nknskscknc 481 hkeeahglvr eylkiklnis phgernqrtk dkrkcimkyn assnninkmp gesevlgsti 541 ltdihfkdvv tvkfrdfkak frkvkina // LOCUS NP_012941 540 aa linear PLN 30-JUN-2025 DEFINITION Mic60p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012941 VERSION NP_012941.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179806.1 REFERENCE 1 (residues 1 to 540) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 540) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 540) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 540) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09171. Method: conceptual translation. FEATURES Location/Qualifiers source 1..540 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..540 /product="Mic60p" /calculated_mol_wt="60951" Region <130..533 /region_name="Mitofilin" /note="Mitochondrial inner membrane protein; pfam09731" /db_xref="CDD:430783" CDS 1..540 /gene="MIC60" /locus_tag="YKR016W" /gene_synonym="AIM28; FCJ1; FMP13" /coded_by="NM_001179806.1:1..1623" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:19528297]" /experiment="EXISTENCE:direct assay:GO:0030061 mitochondrial crista [PMID:19528297]" /experiment="EXISTENCE:direct assay:GO:0044284 mitochondrial crista junction [PMID:22009199]" /experiment="EXISTENCE:direct assay:GO:0061617 MICOS complex [PMID:21987634|PMID:22009199|PMID:21944719]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:22009199|PMID:21944719|PMID:21987634|PMID:19528297]" /experiment="EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:21944719]" /experiment="EXISTENCE:physical interaction:GO:0045041 protein import into mitochondrial intermembrane space [PMID:21944719]" /note="Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic60p is also involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; ortholog of mammalian mitofilin" /db_xref="GeneID:853886" /db_xref="SGD:S000001724" ORIGIN 1 mmlrttasrk ivlrrglasi ntgttvaskk ashkfrntlw tialsatafy aggiiysqkn 61 dkfgdffsnn vpfaedllet yehyhdrptl fledswdglk aksndllsgl tgssqtrrsn 121 renievkkil sleplniete nsdpqlkeii gslndlinsl ndsnlsipes efnsikksnq 181 nmltnlsqln etlkealsny miqrtsevit elntqyensk refeknlqkn llqevdefke 241 nltkqkdkel eeklkaneel lqakhanevg llsitqvkef nkiikdkiek erngrlahle 301 einsevndls ksidrsskil sknealvqlt fqvdeiksri nnnnlpdvni dkelsrlkll 361 snllstfnkk sccddgdccs ckkgnknegk egkisckckp ktnppsllsv aldelestcs 421 gkkilsneqi ynrwnlladd fktasllppn sgilgqltak vfslflftkt gnpsnatdfd 481 svyarvgdnl rvsnlndave evvslkgwph kvceswieda rrklevqrlv eildceirtl // LOCUS NP_012942 551 aa linear PLN 30-JUN-2025 DEFINITION E3 ubiquitin-protein ligase HEL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012942 VERSION NP_012942.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179807.3 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 551) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09172. On Jul 30, 2012 this sequence version replaced NP_012942.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..551 /product="E3 ubiquitin-protein ligase HEL1" /EC_number="2.3.2.31" /calculated_mol_wt="63438" Region 177..228 /region_name="RING-HC_RBR_HEL2-like" /note="RING finger, HC subclass, found in Saccharomyces cerevisiae histone E3 ligase 2 (HEL2) and similar proteins; cd16625" /db_xref="CDD:438287" Region 249..323 /region_name="BRcat_RBR_ANKIB1" /note="BRcat domain found in ankyrin repeat and IBR domain-containing protein 1 (ANKIB1) and similar proteins; cd20346" /db_xref="CDD:439007" Region 333..388 /region_name="Rcat_RBR_HHARI-like" /note="Rcat domain found in human homolog of Drosophila Ariadne (HHARI) and similar proteins; cd20356" /db_xref="CDD:439017" CDS 1..551 /gene="HEL1" /locus_tag="YKR017C" /coded_by="NM_001179807.3:1..1656" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:22570702]" /experiment="EXISTENCE:mutant phenotype:GO:0036205 histone catabolic process [PMID:22570702]" /note="RING finger ubiquitin ligase (E3); involved in ubiquitination and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU)" /db_xref="GeneID:853887" /db_xref="SGD:S000001725" ORIGIN 1 mssgtendqf ysfdesdsss ielyeshnts eftihglvfp klisvtsqds efdinededg 61 vdtiyegmld apltknnkri lcegsvpnls yeclttkgif ermlqrvdhl qpifaipsad 121 ilillqhydw neerllevwt ekmdellvel glsttanikk dndynshfre vefkndftci 181 iccdkkdtet falecgheyc incyrhyikd klhegniitc mdcslalkne didkvmghps 241 ssklmdssik sfvqkhnrny kwcpfadcks ivhlrdtssl peytrlhysp fvkcnsfhrf 301 cfncgfevhs padckittaw vkkarkesei lnwvlshtke cpkcsvniek nggcnhmvcs 361 sckyefcwic egpwaphgkn ffqctmyknn ednksknpqd anktlkkytf yyrlfnehev 421 sakldwnlgq tlgtkvhalq erigiswidg qflseslkvl negrtvlkws favayysdas 481 hnltkifvdn qmllanaves lsellqiktp evimkrrpef ynkagyvenr ttalmecgre 541 llckgickaa e // LOCUS NP_012943 725 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKR018C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012943 VERSION NP_012943.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179808.1 REFERENCE 1 (residues 1 to 725) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 725) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 725) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 725) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09173. Method: conceptual translation. FEATURES Location/Qualifiers source 1..725 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..725 /product="uncharacterized protein" /calculated_mol_wt="81623" Region 36..629 /region_name="Iml2-TPR_39" /note="Iml2/Tetratricopeptide repeat protein 39; pfam10300" /db_xref="CDD:463047" CDS 1..725 /locus_tag="YKR018C" /coded_by="NM_001179808.1:1..2178" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication" /db_xref="GeneID:853888" /db_xref="SGD:S000001726" ORIGIN 1 mfkvfgfgak eeipelsqee ktkailkqah dfeqalramd yvlddnadeg lalldesdak 61 easdqtinal argvieflea tlgfeaeemk kasatlakae alslksrera qkiglksssl 121 yppgtvyavt ytescllhal lmifsesmme aakailklrk syymlqeile tikaankakk 181 lkitsgsedk estpatfitg gdafnsvdip yeltpeeqkd kdllqfaeqi hsmrterlsg 241 ahignspain rlrgelglqa medlpeeeit dhkvlsddid lsqatidefv hsgvnlcfgi 301 lqvvisllpp aigavlsvvg frgsreeglr lvwkatkqrn vhgcigllal mfyydgpfqf 361 tdddfdipaa vkdssnseds edeemdgptl lhpgkileda llqsralfpn salwllnear 421 mlsgkgrlee avalmdsidv skirmrqvks lmifdraitl ihlhqydraa edilslldis 481 dwshafytyf agccylenwr mcemglmksd kkdeyqkkae eliftsvnll gkktfksknl 541 pldrfilrkv eqfkakkeel gvenpldgia tspvheiayf yngynrmsee hleltkkmlt 601 eyrnpaieal dsdqelikdl lvsltlrrlg hiqegcdild ekvlpkffsi qngkvkyikk 661 tedpwaypta lyeralftwk legmdglpes kewllraqgy addyelstrv gmkikaaidr 721 vdhsl // LOCUS NP_012944 615 aa linear PLN 30-JUN-2025 DEFINITION Irs4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012944 VERSION NP_012944.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179809.3 REFERENCE 1 (residues 1 to 615) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 615) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 615) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 615) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09174. On Jul 30, 2012 this sequence version replaced NP_012944.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..615 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..615 /product="Irs4p" /calculated_mol_wt="68749" Region <498..570 /region_name="EH" /note="Eps15 homology domain; smart00027" /db_xref="CDD:197477" CDS 1..615 /gene="IRS4" /locus_tag="YKR019C" /coded_by="NM_001179809.3:1..1848" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18298591]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:genetic interaction:GO:0006914 autophagy [PMID:18298591]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:15265867]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:10082585]" /note="EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication" /db_xref="GeneID:853889" /db_xref="SGD:S000001727" ORIGIN 1 mrlsfgkqry hggttvtlte qgasdslraa qaifqnhsne vsspcppvtv srnpqtrlse 61 pslqksgrkq eqkkarirtk qvpkikttap ndvelskkhr sspagkdnvs staqmaaala 121 hsqsklssdn nsshssaldt lkvletpnln gllgihsrss srngsneslt pgqrtpdnrs 181 qenlltsfss grrlssssme patnkdsnka lpkrrpsppl qsslvgsgql henenlssis 241 idsrhslnpd tsdvisnrsq tslsqtinql slcesepsia ssntttttsn qgsglpnlvp 301 nyssdmrkkk lvnkfkrkvf gskpkhlssq yemdasseel gqheqqpsmr fkttlrktsv 361 stnaendhas slhegnlryk ynpsndtydv yddtdsdses dqnqdaltkp rkrdrikrki 421 rnsanktahh rpihrtrdrk fnedkpwksh tditfvtdne rkryesmwvs nrhrhlnlls 481 wwpsitgdsg aintlpedgl ilgiivrdiw krsnlpnsll aeiytkvdtr kdgtldrksf 541 ivgmwlvdqc lygrklpnvv eqcvwdsvdr yasttvvpvs tlkamakqkr kqmkeeikni 601 kkenrvvlvd hnsss // LOCUS NP_012945 164 aa linear PLN 30-JUN-2025 DEFINITION Vps51p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012945 VERSION NP_012945.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179810.1 REFERENCE 1 (residues 1 to 164) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 164) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 164) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 164) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09175. Method: conceptual translation. FEATURES Location/Qualifiers source 1..164 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..164 /product="Vps51p" /calculated_mol_wt="18781" Region 84..164 /region_name="Vps51" /note="Vps51/Vps67; cl46298" /db_xref="CDD:480638" CDS 1..164 /gene="VPS51" /locus_tag="YKR020W" /gene_synonym="API3; VPS67; WHI6" /coded_by="NM_001179810.1:1..495" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:12377769]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0007118 budding cell apical bud growth [PMID:11957109]" /experiment="EXISTENCE:direct assay:GO:0042147 retrograde transport, endosome to Golgi [PMID:12686613]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:12446664]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:12446664]" /experiment="EXISTENCE:mutant phenotype:GO:0090156 intracellular sphingolipid homeostasis [PMID:26357016]" /experiment="EXISTENCE:physical interaction:GO:0000938 GARP complex [PMID:12446664|PMID:12377769]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12377769]" /note="Component of the GARP (Golgi-associated retrograde protein) complex; GARP is required for the recycling of proteins from endosomes to the late Golgi, and for mitosis after DNA damage induced checkpoint arrest; links the (VFT/GARP) complex to the SNARE Tlg1p; members of the GARP complex are Vps51p-Vps52p-Vps53p-Vps54p" /db_xref="GeneID:853890" /db_xref="SGD:S000001728" ORIGIN 1 maeqishkks lrvsslnkdr rlllrefynl enepnkgrqe arigekasea hsgeeqvtdv 61 nidteantek pvkddelsat eedlkegsed aeeeiknlpf krlvqihnkl lgketetnns 121 ikntiyenyy dlikvndllk eitnanedqi nklkqtvesl ikel // LOCUS NP_012946 915 aa linear PLN 30-JUN-2025 DEFINITION Aly1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012946 VERSION NP_012946.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179811.4 REFERENCE 1 (residues 1 to 915) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 915) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 915) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 915) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 915) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 915) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 915) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09176. On Jul 30, 2012 this sequence version replaced NP_012946.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..915 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..915 /product="Aly1p" /calculated_mol_wt="102410" Region 347..517 /region_name="Arrestin_C" /note="Arrestin (or S-antigen), C-terminal domain; smart01017" /db_xref="CDD:214976" CDS 1..915 /gene="ALY1" /locus_tag="YKR021W" /gene_synonym="ART6" /coded_by="NM_001179811.4:1..2748" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:20739461]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:20739461]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0051453 regulation of intracellular pH [PMID:38248315]" /experiment="EXISTENCE:genetic interaction:GO:2000397 positive regulation of ubiquitin-dependent endocytosis [PMID:20956561]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:23824189]" /experiment="EXISTENCE:mutant phenotype:GO:0032386 regulation of intracellular transport [PMID:20739461]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]" /note="Alpha arrestin, substrate of calcineurin; controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; dephosphorylation of Aly1p required for the endocytosis of Dip5p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets; regulates intracellular pH; ALY1 has a paralog, ALY2, that arose from the whole genome duplication" /db_xref="GeneID:853891" /db_xref="SGD:S000001729" ORIGIN 1 mlqfntendt vapvfpmeqd inaapdavpl vqtttlqvfv klaepivflk gfetnglsei 61 apsilrgsli vrvlkpnklk sisitfkgis rtewpegipp kreefsdvet vvnhtwpfyq 121 addgmnsftl ehhssnnssn rpsmsdedyl leksgasvyi pptaeppkdn snlsldayer 181 nslssdnlsn kpvssdvshd dskllaiqkt plpsssrrgs vpanfhgnsl sphtfisdlf 241 tktfsnsgat pspeqednyl tpskdskevf ifrpgdyiyt feqpisqsyp esikanfgsv 301 eyklsidier fgafkstiht qlpikvvrlp sdgsveetea iaiskdwkdl lhydvvifsk 361 eivlnaflpi dfhfapldkv tlhririylt esmeytcnsn gnhekarrle ptkkfllaeh 421 ngpklphipa gsnplkaknr gnilldeksg dlvnkdfqfe vfvpskftns irlhpdtnyd 481 kikahhwiki clrlskkygd nrkhfeisid spihilnqlc shantllpsy eshfqycded 541 gnfapaadqq nyashhdsni ffpkevlssp vlspnvqkmn iripsdlpvv rnraesvkks 601 ksdntskknd qssnvfaskq lvaniykpnq ipreltspqa lplspitspi lnyqplsnsp 661 ppdfdfdlak rgaadshaip vdppsyfdvl kadgielpyy dtssskipel klnksretla 721 sieedsfngw sqiddlsded dndgdiasgf nfklstsaps envnshtpil qslnmsldgr 781 kknraslhat svlpstirqn nqhfndinqm lgssdedafp ksqslnfnkk lpilkindnv 841 iqsnsnsnnr vdnpedtvds svditafydp rmssdskfdw evsknhvdpa aysvnvasen 901 rvlddfkkaf rekrk // LOCUS NP_012947 322 aa linear PLN 30-JUN-2025 DEFINITION Ntr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012947 VERSION NP_012947.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179812.1 REFERENCE 1 (residues 1 to 322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 322) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09177. Method: conceptual translation. FEATURES Location/Qualifiers source 1..322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..322 /product="Ntr2p" /calculated_mol_wt="36516" Region 76..313 /region_name="NTR2" /note="Nineteen complex-related protein 2; pfam15458" /db_xref="CDD:464728" CDS 1..322 /gene="NTR2" /locus_tag="YKR022C" /coded_by="NM_001179812.1:1..969" /experiment="EXISTENCE:direct assay:GO:0000390 spliceosomal complex disassembly [PMID:16357217|PMID:16880513]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005681 spliceosomal complex [PMID:16880513]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071008 U2-type post-mRNA release spliceosomal complex [PMID:16357217]" /experiment="EXISTENCE:mutant phenotype:GO:0000390 spliceosomal complex disassembly [PMID:16880513]" /note="Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly" /db_xref="GeneID:853892" /db_xref="SGD:S000001730" ORIGIN 1 maikkrnkir lpsgspeevg idgsahkpmq qikplvsnds edddndicvl qpikfkkvpk 61 rditfdgeqa ikednshyed lyhskkntna strnkddlli lnmedlmegn hhllsdssea 121 gsssegehis siptrgeiak lkaqkslsrr kisesdvtte rdyvklldse dkreimetir 181 lngglkrnne keitnfsdde mqgfqdemla ltdnqiaiqk dskrkiieka inevpyrtne 241 ewetqllskg ninksnekii tplpvlfpdd desgnsieri nemvskiclq rkkvemrlqa 301 lektkidlek skaslinkli gn // LOCUS NP_012948 530 aa linear PLN 30-JUN-2025 DEFINITION Rqt4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012948 VERSION NP_012948.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179813.3 REFERENCE 1 (residues 1 to 530) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 530) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 530) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 530) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09178. On Jul 30, 2012 this sequence version replaced NP_012948.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..530 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..530 /product="Rqt4p" /calculated_mol_wt="60668" Region 173..227 /region_name="zf-C2HC5" /note="Putative zinc finger motif, C2HC5-type; pfam06221" /db_xref="CDD:428833" CDS 1..530 /gene="RQT4" /locus_tag="YKR023W" /coded_by="NM_001179813.3:1..1593" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:36627279]" /experiment="EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:36627279]" /experiment="EXISTENCE:direct assay:GO:0072344 rescue of stalled ribosome [PMID:36627279|PMID:30893611]" /experiment="EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:28757607]" /note="Subunit of ribosome-associated quality control trigger complex (RQT); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:853893" /db_xref="SGD:S000001731" ORIGIN 1 mtrkqaidya ikqvpqilpl eesdvkalce qvlstssddp eqiaskflef lghedlsfef 61 vmkfnellnq ndkkeekktk nvhlehtapt swkneskqpt nnyinkkgde kpkklkdekk 121 ssttrptvqp snqstqsnpi kekkehrskg klqslqeide aikmlelrds gsskncncqg 181 trhpvfdiap nclhcgkvvc vieglnkgkc ghcheqlisd nertqmveil nqeknelngs 241 ssslsnasng anvpkkktkt ykitsgmgkn lfaeqdklfd fierkrerer krnevlklqe 301 ekeeseaker qasehdhkae enpellaaqe rldrllyfqd tsaertkiid nasdfdmnqe 361 vglwgsarer alalkkqqrn lrkwekveke rngrrekyvv smnigsngkv tmtevpkdte 421 nviagsdddi sdisdeedis dlkhihalks einttkslen lhlqskawdy erdkkqfdrp 481 tyvkknsdta qqnrkteeka hdmqaydlks rvqvdqnada sveqnilavl // LOCUS NP_012949 742 aa linear PLN 30-JUN-2025 DEFINITION putative ATP-dependent RNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012949 VERSION NP_012949.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179814.1 REFERENCE 1 (residues 1 to 742) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 742) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 742) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 742) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09179. Method: conceptual translation. FEATURES Location/Qualifiers source 1..742 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..742 /product="putative ATP-dependent RNA helicase" /EC_number="3.6.4.13" /calculated_mol_wt="83177" Region 145..626 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" Region 154..373 /region_name="DEADc_DDX31" /note="DEAD-box helicase domain of DEAD box protein 31; cd17949" /db_xref="CDD:350707" Site order(163..164,166..168,171,192..199) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350707" Region 640..700 /region_name="DUF4217" /note="Domain of unknown function (DUF4217); pfam13959" /db_xref="CDD:464056" CDS 1..742 /gene="DBP7" /locus_tag="YKR024C" /coded_by="NM_001179814.1:1..2229" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9582098]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9582098]" /experiment="EXISTENCE:mutant phenotype:GO:0000464 endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:34686661]" /note="Putative ATP-dependent RNA helicase of the DEAD-box family; involved in ribosomal biogenesis; required at post-transcriptional step for efficient retrotransposition; essential for growth under anaerobic conditions" /db_xref="GeneID:853894" /db_xref="SGD:S000001732" ORIGIN 1 msdedsmlln fttnedtags sykqaakvtg grwkdrrrmk mklegktvsr krkanttgde 61 giipgrgens ikklhkessy sseeqekykg rnahntqgrt lpadsqfvss lftsnreitt 121 avntnihden vainpsnapl kgdqfaslgv ssllvshleq kmrikkptsi qkqaipqiig 181 nagkndffih aqtgsgktls yllpiistil nmdthvdrts gafalviapt relasqiyhv 241 cstlvscchy lvpclligge rkksekarlr kgcnfiigtp grvldhlqnt kvikeqlsqs 301 lryivldegd klmelgfdet iseiikivhd ipinsekfpk lphklvhmlc satltdgvnr 361 lrnvalkdyk lisngtkkds divtvapdql lqritivppk lrlvtlaatl nnitkdfias 421 gqqsktlrti vfvscsdsve fhydafsgsd ghhknltgds vrlltkgntm fpcfsdsrdp 481 dvviyklhgs lsqqmrtstl qhfardneat kgkhlimfct dvasrgldlp hvgsvieldp 541 pfavedhlhr vgrtaragek gesllfllpg eeekymdyiq pyhpmgwell kfdkeilmpa 601 fkdvnvnrnd kfirkdekss knkdvgdkey ewdtnattwh lnierrvvgd safknlavkg 661 fishvrayat hisqekkffn vkflhlghla ksfglrerpk amglqsskdg nsekkptken 721 sknkmfrmar maekqiasef ny // LOCUS NP_012950 282 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase III subunit C37 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012950 VERSION NP_012950.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179815.3 REFERENCE 1 (residues 1 to 282) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 282) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 282) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 282) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09180. On Jul 30, 2012 this sequence version replaced NP_012950.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..282 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..282 /product="DNA-directed RNA polymerase III subunit C37" /calculated_mol_wt="32011" Region 69..>282 /region_name="RPC5" /note="RPC5 protein; pfam04801" /db_xref="CDD:461434" CDS 1..282 /gene="RPC37" /locus_tag="YKR025W" /coded_by="NM_001179815.3:1..849" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /note="RNA polymerase III subunit C37" /db_xref="GeneID:853895" /db_xref="SGD:S000001733" ORIGIN 1 msidnklfvt eedeedrtqd radvedesnd idmiadengt nsaianeqee kseevkaedd 61 tgeeeeddpv ieefplkisg eeeslhvfqy anrprlvgrk paehpfisaa rykpkshlwe 121 idipldeqaf ynkdkaesew ngvnvqtlkg vgvenngqya afvkdmqvyl vpiervaqlk 181 pffkyiddan vtrkqedarr npnpssqraq vvtmsvksvn dpsqnrltgs llahkvadee 241 anieltwaeg tfeqfkdtiv keaedktlva lekqedyidn lv // LOCUS NP_012951 305 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF2B subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_012951 VERSION NP_012951.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179816.1 REFERENCE 1 (residues 1 to 305) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 305) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 305) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 305) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09181. Method: conceptual translation. FEATURES Location/Qualifiers source 1..305 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..305 /product="translation initiation factor eIF2B subunit alpha" /calculated_mol_wt="33894" Region 15..292 /region_name="IF-2B" /note="Initiation factor 2 subunit family; pfam01008" /db_xref="CDD:395798" CDS 1..305 /gene="GCN3" /locus_tag="YKR026C" /gene_synonym="AAS2" /coded_by="NM_001179816.1:1..918" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:8336705]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8506384|PMID:8336705]" /experiment="EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:8506384]" /experiment="EXISTENCE:genetic interaction:GO:0006446 regulation of translational initiation [PMID:8887689]" /experiment="EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:8887689]" /experiment="EXISTENCE:genetic interaction:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:6351059]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:34223816|PMID:8099443]" /experiment="EXISTENCE:mutant phenotype:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8099443]" /experiment="EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:9032257|PMID:8099443]" /experiment="EXISTENCE:mutant phenotype:GO:0030234 enzyme regulator activity [PMID:8887689|PMID:8099443|PMID:9032257]" /experiment="EXISTENCE:mutant phenotype:GO:0045948 positive regulation of translational initiation [PMID:34223816]" /experiment="EXISTENCE:mutant phenotype:GO:1900036 positive regulation of cellular response to heat [PMID:34223816]" /experiment="EXISTENCE:mutant phenotype:GO:1903833 positive regulation of cellular response to amino acid starvation [PMID:6351059]" /experiment="EXISTENCE:physical interaction:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8506384]" /experiment="EXISTENCE:physical interaction:GO:0006446 regulation of translational initiation [PMID:8887689]" /note="Alpha subunit of translation initiation factor eIF2B (eIF2Balpha); guanine-nucleotide exchange factor for eIF2; mutations in eIF2Balpha alter localization of eIF2B; activity regulated by phosphorylated eIF2; positive regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog EIF2B1 can complement yeast null mutant" /db_xref="GeneID:853896" /db_xref="SGD:S000001734" ORIGIN 1 msefnitety lrfleedtem tmpiaaieal vtllriktpe taaemintik ssteeliksi 61 pnsvslragc difmrfvlrn lhlygdwenc kqhliengql fvsrakksrn kiaeigvdfi 121 adddiilvhg ysravfslln haankfirfr cvvtesrpsk qgnqlytlle qkgipvtliv 181 dsavgavidk vdkvfvgaeg vaesggiinl vgtysvgvla hnarkpfyvv teshkfvrmf 241 plssddlpma gppldftrrt ddledalrgp tidytaqeyi talitdlgvl tpsavseeli 301 kmwyd // LOCUS NP_012952 765 aa linear PLN 30-JUN-2025 DEFINITION Bch2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012952 VERSION NP_012952.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179817.3 REFERENCE 1 (residues 1 to 765) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 765) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 765) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 765) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 765) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 765) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 765) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09182. On Jul 30, 2012 this sequence version replaced NP_012952.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..765 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..765 /product="Bch2p" /calculated_mol_wt="87913" Region 92..564 /region_name="ChAPs" /note="ChAPs (Chs5p-Arf1p-binding proteins); pfam09295" /db_xref="CDD:401292" CDS 1..765 /gene="BCH2" /locus_tag="YKR027W" /gene_synonym="FMP50" /coded_by="NM_001179817.3:1..2298" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0030140 trans-Golgi network transport vesicle [PMID:16498409]" /experiment="EXISTENCE:direct assay:GO:0034044 exomer complex [PMID:17000877]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]" /experiment="EXISTENCE:physical interaction:GO:0006031 chitin biosynthetic process [PMID:16498409]" /note="Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BCH2 has a paralog, CHS6, that arose from the whole genome duplication" /db_xref="GeneID:853898" /db_xref="SGD:S000001735" ORIGIN 1 msflwgstks kkgknkkaag slpsgvvpqq rvkptrknvp idyprtlekv hgeslifrts 61 llselvstgk sgigppdlih cteldkfhde kigeffyitg idassvsmpi aflklikwnd 121 gkklksaslk nddittyctf nifqkldirl ryesedvyqv nivdclngnn eiplsdliwe 181 etfvsccirs viinsdferk ipglvelpfv fenrcasdyk rvidslckfl prflecgwds 241 tksvyatiln nyltesllvf lsitpefitd yaiqvldnlm tndpsnsryy aiviisimer 301 sndrdvemik riheildlll pvlyglpsde pyisdlinci tdvlsiqarf llnnndyels 361 lsistlatnl ssdnfeswyl lskgyifsqq ydkallsins mpclaeydiv kqaqinafkf 421 ymnyykaplc hsrehctmts helnhlmnim hyenelelkt iifgrtvmpn eskygcieei 481 wnksclelgp icgpqsdnli nfvsqqevnt vgdmlllkrs ketrqeswfi kqvrlllmel 541 varigwnall qlrsdvfvme skfkmiessd klstelrqkr lcqrwfdamf ldvyedlsis 601 tssqenkata kysglewell gltllrvsdl pdavaclrts ilarfdpisc hhllnfyltm 661 dfndefmrrf dvdiildllv klisfrirfy drfqifslqv lrklegqlgs eiiknkiins 721 pygqagitsv idymleclsk nrneaclaye rplpdlpsti kplad // LOCUS NP_012953 1033 aa linear PLN 30-JUN-2025 DEFINITION Sap190p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012953 VERSION NP_012953.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179818.2 REFERENCE 1 (residues 1 to 1033) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1033) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1033) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1033) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1033) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1033) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1033) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09183. On Apr 26, 2011 this sequence version replaced NP_012953.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1033 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1033 /product="Sap190p" /calculated_mol_wt="116968" Region 266..762 /region_name="SAPS" /note="SIT4 phosphatase-associated protein; pfam04499" /db_xref="CDD:398279" CDS 1..1033 /gene="SAP190" /locus_tag="YKR028W" /coded_by="NM_001179818.2:1..3102" /experiment="EXISTENCE:genetic interaction:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8649382]" /experiment="EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:15367655]" /note="Protein that forms a complex with the Sit4p protein phosphatase; required for Sit4p function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p; SAP190 has a paralog, SAP185, that arose from the whole genome duplication" /db_xref="GeneID:853899" /db_xref="SGD:S000001736" ORIGIN 1 msgsfwkfgq dysiespvsk ilnsafikin kdqdddvptg tceeniadde dnsshdyaas 61 ednvvnenee keeentlptt eseyenyrpn ldvlddlldd delytelmcs nfklliflky 121 pdvlskliey vtnekildee tdsakkpeii egvndhpili erdrkdkked aeeggdseet 181 tndsdhdsgd ersvdseets itlppeseeq vetrrariaa eilsadvwpi saaimqnkdl 241 lgrlwsildh paplpipast yfmkinerll dmditgmlef ilsrdslvar flthvdnpsl 301 mdfllkvist dkpdsptgvi kilksqelip klldhlnpey gistqsaagd fikafvtlst 361 nssnelasgi gpneltrqlv seemieklik imlkggtsls ngvgiiieli rknnsdydfi 421 qlvyttlesh pptdrdpihl ihlvklfakh mpdfadmldk tklplmempf gnieplgfer 481 fkiceliael lhcsnmtlln epngemiaqe rdierakele tstekenita ivdnkssyyd 541 kdcvekdite nlgalqinnq gseedelndt gvssvkldvk sdakvvegle ndasgvelyd 601 etlsdtesvr eclrekplvg drlkialedt kilisildmf tefpwnnflh nvifdiaqqi 661 fngplktgyn rfllkdylvd ayltkkivda dkacqdyekk tglrygymgh ltlvaeeisk 721 fkeyidemkl tfcntavsdr leepfwkeys etiladtrek yntvlgdfgn dqesdddvir 781 nsdsediigd tegnenygng endellsngh dsgnmdlyyn fnnneneene edyaeysdvd 841 nknyynnvet ndddydsddg ksksaeseft dkisehrdgn slynednden gsdkwtsgts 901 lfppdhfpsr sqpsdpklqd qnifhhqfdf egvgddddym dpnddgqsya rpgnplyttp 961 ktpprpktil fnslsaldnn gedeevalgt svddrmdnei ssdeedsede deendmgnee 1021 gyslyrsrsk eaf // LOCUS NP_012954 751 aa linear PLN 30-JUN-2025 DEFINITION histone-binding protein SET3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012954 VERSION NP_012954.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179819.3 REFERENCE 1 (residues 1 to 751) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 751) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 751) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 751) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 751) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09184. On Jul 30, 2012 this sequence version replaced NP_012954.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..751 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..751 /product="histone-binding protein SET3" /calculated_mol_wt="85349" Region 119..163 /region_name="PHD_MLL5" /note="PHD finger found in mixed lineage leukemia 5 (MLL5); cd15550" /db_xref="CDD:277025" Site order(127,129..133,135,140,154..158) /site_type="other" /note="histone H3 binding site [polypeptide binding]" /db_xref="CDD:277025" Region 321..507 /region_name="SET_SpSET3-like" /note="SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; cd19183" /db_xref="CDD:380960" Site order(334..335,352,362,376..383,400..404,412,442,453..459) /site_type="active" /note="putative active site [active]" /db_xref="CDD:380960" Site order(334..335,376..379,400..404,455) /site_type="other" /note="putative SAM binding site" /db_xref="CDD:380960" CDS 1..751 /gene="SET3" /locus_tag="YKR029C" /coded_by="NM_001179819.3:1..2256" /experiment="EXISTENCE:direct assay:GO:0034967 Set3 complex [PMID:11711434]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:17142463]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:19379692]" /experiment="EXISTENCE:mutant phenotype:GO:0006479 protein methylation [PMID:31960028]" /experiment="EXISTENCE:mutant phenotype:GO:0045815 transcription initiation-coupled chromatin remodeling [PMID:35579426]" /experiment="EXISTENCE:mutant phenotype:GO:0045835 negative regulation of meiotic nuclear division [PMID:11711434]" /note="Defining member of the SET3 histone deacetylase complex; which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication" /db_xref="GeneID:853900" /db_xref="SGD:S000001737" ORIGIN 1 msvpnskeqs llddastlll fskgkkraee askigsktdt iehdeshere kkgaiemaaa 61 alatastvsl plkkateqsa aeaatstaak eetenqpqkq pqwpvpdsyi vdpdagiitc 121 icdlndddgf tiqcdhcnrw qhaicygikd igmapddylc nscdprevdi nlarkiqqer 181 invktvepss snnsasnknn grdrasstti sdvgdsfstd qdntnhrdkr rkrnpsnnsi 241 dsknesasvn ssdgltsmpk kkehflsakd aygaiylplk dnvfksdlie pflnkhmddn 301 wviqyphktf ksvsievkpy adiaysrtyp gftklgvylk kdcikgdfiq eilgeldfyk 361 nyltdprnhy riwgtakrrv ifhshwpiyi darlsgnstr ylrrscqpnv elvtiklqdt 421 dnrndkssgr kssrikfvlr alrdisedee lyikwqwdsk hpilklikgm tidslddler 481 yglinsveti lsngecgcgn nskdcyllkv kryaqslyks vksrgkmnnr yklneilnqy 541 nckkrreppi lhrleekaqn tierapilln nfyrqkflnr nngpkipqkn tidstnnpdd 601 iakpfkfalf aqhssnisvp kknetsekpl iitkstdyde shitnieelp ipvllpinkt 661 srqtandvee sqsknehkls rtpslsnfnk elskeaqhsq aktkeimtea svnsrrestp 721 esimhlsdfs ssqlhskkkl sfadyrkkll k // LOCUS NP_012955 273 aa linear PLN 30-JUN-2025 DEFINITION Gmh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012955 VERSION NP_012955.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179820.1 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 273) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09185. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..273 /product="Gmh1p" /calculated_mol_wt="31862" Region 41..273 /region_name="UNC-50" /note="UNC-50 family; pfam05216" /db_xref="CDD:461592" CDS 1..273 /gene="GMH1" /locus_tag="YKR030W" /gene_synonym="MSG1" /coded_by="NM_001179820.1:1..822" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12808035]" /experiment="EXISTENCE:physical interaction:GO:0016192 vesicle-mediated transport [PMID:12808035]" /note="Golgi membrane hypothetical protein; interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting; conserved from yeast to human" /db_xref="GeneID:853901" /db_xref="SGD:S000001738" ORIGIN 1 msylptysnd lpagpqgqrr rnngnendar qgygqqsvpm virrlfktpk nldletaswe 61 mfhlifhprk ayrsiyyqrq tknqwarddp sffifqiali slssiiwsiy nsgfnndsdm 121 galsiighff kslvmmvild ffifgfimat ifylllnrsh fkfkssqnsv vewaycfdvh 181 cnsfliillc lyfiqflllp iinlqnwisl lignslycfa ighyfiltfy gynqlpflkn 241 lnfillptlg lsiiylislf gidlskklsf yny // LOCUS NP_012956 1683 aa linear PLN 30-JUN-2025 DEFINITION phospholipase D [Saccharomyces cerevisiae S288C]. ACCESSION NP_012956 VERSION NP_012956.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179821.3 REFERENCE 1 (residues 1 to 1683) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1683) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1683) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1683) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09186. On Jul 30, 2012 this sequence version replaced NP_012956.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1683 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1683 /product="phospholipase D" /EC_number="3.1.4.4" /calculated_mol_wt="195074" Region 300..>390 /region_name="PX_domain" /note="The Phox Homology domain, a phosphoinositide binding module; cl02563" /db_xref="CDD:470617" Region 473..660 /region_name="PH_PLD" /note="Phospholipase D pleckstrin homology (PH) domain; cd01254" /db_xref="CDD:269956" Region <638..1165 /region_name="PLN02866" /note="phospholipase D" /db_xref="CDD:215467" CDS 1..1683 /gene="SPO14" /locus_tag="YKR031C" /gene_synonym="PLD1" /coded_by="NM_001179821.3:1..5052" /experiment="EXISTENCE:direct assay:GO:0004630 phospholipase D activity [PMID:11514437]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:9693364]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21954159]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0006644 phospholipid metabolic process [PMID:8576189]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:genetic interaction:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:18036176]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:12702348]" /experiment="EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:8576189]" /experiment="EXISTENCE:mutant phenotype:GO:0031321 ascospore-type prospore assembly [PMID:16554438]" /note="Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions" /db_xref="GeneID:853902" /db_xref="SGD:S000001739" ORIGIN 1 msnvstasgt hfappqadrs vteevdrvns rpdelenqev lrqlpengnl tsslqrekrr 61 tpngkeaerk halpksfvdr nlsdvspnhs ldhimhsneh dprrgsdeen mhrlynnlhs 121 snnnvhskrn skreeerapq rrsssvaytq qqfngwkkef ghafkkisai grlkssvnsp 181 tpagsghrhn qhqhqqvnee dlytqrlasd lldsllagcp aslfastqfl rdehgkrrap 241 lllakldvrv splkndnnil ditnsnhnhr gnnnnntgen sdrrpsiprs ssiisissnv 301 aefmysrnen slfrihleyg idedrlkwsi irsykdiksl hhklkivafq qltisklysd 361 nnryhslqlp hfphykemvk ernvmekkae nkpssaasap htsennnndn gsnitsletl 421 ssseisefni dnvkmkhlqd lidepddfsq pihlrleryl rllnialclr phanrlfefy 481 elsplgnlls resgfqgkqg ylvirstaka qgwrvshfgk hafkdmidrh ttkwflvrns 541 yltyvsdlss ttpldvflid wkfkvrfsgn knnildnene inwiihdpnl eindeleefg 601 iendannild kngkskthqk ksnissklll ltlenserkl kiicksessl kqwmssiikm 661 ststpwskpn rfgsfapvrt nsfckflvdg rdyfwslsea llmakdviyi hdwwlspely 721 lrrpvkgnqg fridrmlksc aekgikifiv iyrnvgnivg tdslwtkhsm lnlhpnihii 781 rspnqwlqnt yfwahhekfv videtfafig gtdlcygryd tfehvlrdda eslldqnfpg 841 kdysnariad fhdldkpfes mydrkviprm pwhdvqmmtl gepardlarh fvqrwnyllr 901 akrpsrltpl ltppsdltae elkslpmfei lrekstcetq ilrsagnwsl glketecsiq 961 naylklieqs ehfiyienqf fitstvwngt cvlnkigdal vdrivkanqe kkpwkafili 1021 plmpgfdspv dtaeasslrl imqfqyqsis rgehstfskl kklnidpaqy iqffslrkws 1081 tfapnerlit eqlyvhakil iaddrrciig saninersql gnrdsevail irdtdliktk 1141 mngddyyagk fpwelrqrlm rehlgcdvdl vefvekkfer fekfaaknye klhtlskegd 1201 sgnnwsdrem idsamielgy reifgckfsp qwksghgnsv ddgstqcgin ekevgreden 1261 vyekffnsvd ygkssrkrtp lpkhnfaslg ltfnhragie nvgirdhkvl stdprlrknd 1321 ehkkevdgyg pdcwkkesnk kfkadateql kewalnslas kvlddkemik seipegfsny 1381 lpnekdlemy ltdktvtnrn kwsmlkricy lqylshklde rktqrlkkik dmrrhlssst 1441 estrngsnsl plneksnege stnvdqdieg deyhrlhedi lknqelddgs lddllsqiip 1501 kitnfnsgei ddakkeellk lnfidpysfe dplissfseg lwftialrnt llyklvfhcq 1561 pdnavqnwke ygefteleqe fqinqeklid leaeninstt tnvvdkdrek ekmrkaaelr 1621 mklsgsllyg fnqkvfdkht aqrilerihg hlvifptewl akevesrnwi fnsdrlspme 1681 iyn // LOCUS NP_001335791 104 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKR032W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335791 VERSION NP_001335791.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348851.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 104) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80311. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..104 /product="uncharacterized protein" /calculated_mol_wt="12283" CDS 1..104 /locus_tag="YKR032W" /coded_by="NM_001348851.1:1..315" /note="hypothetical protein; conserved among S. cerevisiae strains" /db_xref="GeneID:853903" /db_xref="SGD:S000001740" ORIGIN 1 maysslclcl lfnpkgcsnl hpfvvdnefp pyhlslvlik qqrmldrnrs waylaalwrh 61 pwtviskccl vyiyiqrqle fgysycffdf llvilsetvv ilyy // LOCUS NP_012959 269 aa linear PLN 30-JUN-2025 DEFINITION Dal80p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012959 VERSION NP_012959.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179824.1 REFERENCE 1 (residues 1 to 269) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 269) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 269) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 269) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09187. Method: conceptual translation. FEATURES Location/Qualifiers source 1..269 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..269 /product="Dal80p" /calculated_mol_wt="30035" Region <1..269 /region_name="GAT1" /note="GATA Zn-finger-containing transcription factor [Transcription]; COG5641" /db_xref="CDD:227928" CDS 1..269 /gene="DAL80" /locus_tag="YKR034W" /gene_synonym="UGA43" /coded_by="NM_001179824.1:1..810" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8045902]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11443099]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:8376332]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:7899075|PMID:8045902|PMID:8416910]" /experiment="EXISTENCE:mutant phenotype:GO:0090295 nitrogen catabolite repression of transcription [PMID:6757722|PMID:7899075|PMID:1944286]" /note="Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication" /db_xref="GeneID:853904" /db_xref="SGD:S000001742" ORIGIN 1 mvlsdslklp sptlsaaagv ddcdgedhpt cqncftvktp lwrrdehgtv lcnacglflk 61 lhgeprpisl ktdtiksrnr kklnnnnvnt nanthsndpn kifkrkkrll ttgggslptn 121 npkvsilekf mvsgsikpll kpketvpntk ecstqrgkfs ldpcepsgkn ylyqingsdi 181 ytsnieltrl pnlstlleps pfsdsavpei eltwklhnee eviklktkis elelvtdlyk 241 khifqlnekc kqlevelhsr asvqshpqh // LOCUS NP_012961 204 aa linear PLN 30-JUN-2025 DEFINITION Did2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012961 VERSION NP_012961.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184309.3 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 204) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09188. On Jul 30, 2012 this sequence version replaced NP_012961.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..204 /product="Did2p" /calculated_mol_wt="22960" Region 15..181 /region_name="Snf7" /note="pfam03357" /db_xref="CDD:460896" CDS 1..204 /gene="DID2" /locus_tag="YKR035W-A" /gene_synonym="CHM1; FTI1; VPL30; VPS46" /coded_by="NM_001184309.3:1..615" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11029042]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:11029042]" /experiment="EXISTENCE:direct assay:GO:1904902 ESCRT III complex assembly [PMID:31273031]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:11029042]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:17130288]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12194857]" /note="Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors" /db_xref="GeneID:853906" /db_xref="SGD:S000006435" ORIGIN 1 msrnsaagle ntlfqlkfts kqlqkqanka skeekqetnk lkralnened isriyasnai 61 rkknerlqll klasrvdsva srvqtavtmr qvsasmgqvc kgmdkalqnm nlqqitmimd 121 kfeqqfedld tsvnvyedmg vnsdamlvdn dkvdelmskv adengmelkq sakldnvpei 181 kakevnvdde kedklaqrlr alrg // LOCUS NP_012962 643 aa linear PLN 30-JUN-2025 DEFINITION Caf4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012962 VERSION NP_012962.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179826.2 REFERENCE 1 (residues 1 to 643) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 643) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 643) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 643) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09189. On Apr 26, 2011 this sequence version replaced NP_012962.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..643 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..643 /product="Caf4p" /calculated_mol_wt="72701" Region 83..233 /region_name="Mdv1_N" /note="N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division protein 1 (Mdv1) and similar proteins; cd22881" /db_xref="CDD:467856" Region 318..641 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(318,336,341,347..348,360..361,380,384,390..391, 422..423,438,443,449..450,468,503,508,514..515,527..528, 544,548,554..555,567..568,582,587,593..594,631,635,641) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 322..360 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 366..422 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 427..461 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 472..526 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 532..563 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 571..611 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 617..641 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..643 /gene="CAF4" /locus_tag="YKR036C" /coded_by="NM_001179826.2:1..1932" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16009724|PMID:16823961|PMID:14576278|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030014 CCR4-NOT complex [PMID:11113136]" /experiment="EXISTENCE:genetic interaction:GO:0016559 peroxisome fission [PMID:18445678]" /experiment="EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:16009724]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11113136]" /experiment="EXISTENCE:physical interaction:GO:0000266 mitochondrial fission [PMID:16009724]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11113136]" /note="WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication" /db_xref="GeneID:853908" /db_xref="SGD:S000001744" ORIGIN 1 mgsgdtrges slvakpieii lnklphaila qqqfqkyits piyrylskll lfrevawpes 61 tkdtqkgqvg ifsfqnnyad sattfrilah ldeqryplpn gaaeknlpsl fegfkatvsi 121 iqqrllldnv dgatnsdkek yvqlpdintg fvnktysrid lthlledvet nvenlsinkt 181 lemdeltrld sminelesrk lkilervkhi dskstnlend vtlikdrinf ieeynleadr 241 eqslrkqmee ersseassft qneeaisslc dveskdtrlk dfykmpheks hdknrqiise 301 tysrnttafr mtiphgehgn sitaldfdtp wgtlcsssyq drivkvwdln hgiqvgelpg 361 hlatvncmqi dkknynmlit gskdatlklw dlnlsreiyl dhsplkekte eivtpcihnf 421 elhkdeital sfdsealvsg srdkkifhwd lttgkciqql dliftpthsd ikmparslnn 481 gacllgteap migalqcyns alatgtkdgi vrlwdlrvgk pvrlleghtd gitslkfdse 541 klvtgsmdns vriwdlrtss ildviaydlp vssldfdgkl itvganeggv nvfnmerdeh 601 wmtpepphsl dgdelsrria ivkykdgfli nghndgdinv wtl // LOCUS NP_012963 295 aa linear PLN 30-JUN-2025 DEFINITION Spc34p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012963 VERSION NP_012963.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179827.3 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 295) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09190. On Jul 30, 2012 this sequence version replaced NP_012963.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..295 /product="Spc34p" /calculated_mol_wt="33947" Region 5..293 /region_name="DASH_Spc34" /note="DASH complex subunit Spc34; pfam08657" /db_xref="CDD:400819" CDS 1..295 /gene="SPC34" /locus_tag="YKR037C" /coded_by="NM_001179827.3:1..888" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15664196|PMID:15640796]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:17620411|PMID:20479465]" /experiment="EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479465|PMID:20479468]" /note="Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body" /db_xref="GeneID:853909" /db_xref="SGD:S000001745" ORIGIN 1 mgesldrcid dinravdsms tlyfkppgif hnailqgasn kasirkditr likdcnhdea 61 yllfkvnpek qsvsrrdgke gvfdyvikrd tdmkrnrrlg rpgekpiihv pkevylnkdr 121 ldlnnkrrrt attsggglng fifdtdligs svisnsssgt fkalsavfkd dpqiqrllya 181 lengsvlmee esnnqrrkti fvedfptdli lkvmaevtdl wpltefkqdy dqlyhnyeql 241 ssklrfikke vllqddrlkt msqyhpsssh dvakiirkek deirrlemei anlqe // LOCUS NP_012964 386 aa linear PLN 30-JUN-2025 DEFINITION tRNA N6-adenosine threonylcarbamoyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012964 VERSION NP_012964.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179828.1 REFERENCE 1 (residues 1 to 386) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 386) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 386) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 386) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09191. On Oct 2, 2003 this sequence version replaced NP_012964.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..386 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..386 /product="tRNA N6-adenosine threonylcarbamoyltransferase" /EC_number="2.3.1.234" /calculated_mol_wt="42617" Region 17..360 /region_name="ASKHA_NBD_OSGEP_like_euk" /note="nucleotide-binding domain (NBD) of O-sialoglycoprotein endopeptidase (OSGEP) and similar proteins mainly from eukaryotes; cd24132" /db_xref="CDD:466982" CDS 1..386 /gene="KAE1" /locus_tag="YKR038C" /coded_by="NM_001179828.1:1..1161" /experiment="EXISTENCE:direct assay:GO:0000408 EKC/KEOPS complex [PMID:16874308|PMID:16564010]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16874308]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:23620299]" /experiment="EXISTENCE:direct assay:GO:0008252 nucleotidase activity [PMID:36416748]" /experiment="EXISTENCE:direct assay:GO:0031490 chromatin DNA binding [PMID:16874308]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:36416748]" /experiment="EXISTENCE:mutant phenotype:GO:0008252 nucleotidase activity [PMID:36416748]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18439903]" /experiment="EXISTENCE:mutant phenotype:GO:0070525 tRNA threonylcarbamoyladenosine metabolic process [PMID:21459853|PMID:21183954]" /experiment="EXISTENCE:physical interaction:GO:0000723 telomere maintenance [PMID:16564010]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16874308]" /note="ADP/GDP nucleotidase, essential functional component of KEOPS complex, with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; homolog of human OSGEP" /db_xref="GeneID:853910" /db_xref="SGD:S000001746" ORIGIN 1 mvnlntippk ngrdyyialg legsanklgv givkhpllpk hansdlsydc eaemlsnird 61 tyvtppgegf lprdtarhhr nwcirlikqa laeadikspt ldidvicftk gpgmgaplhs 121 vviaartcsl lwdvplvgvn hcighiemgr eitkaqnpvv lyvsggntqv iaysekryri 181 fgetldiaig ncldrfartl kipnepspgy nieqlakkap hkenlvelpy tvkgmdlsms 241 gilasidlla kdlfkgnkkn kilfdkttge qkvtvedlcy slqenlfaml veiteramah 301 vnsnqvlivg gvgcnvrlqe mmaqmckdra ngqvhatdnr fcidngvmia qaglleyrmg 361 givkdfsetv vtqkfrtdev yaawrd // LOCUS NP_012965 602 aa linear PLN 30-JUN-2025 DEFINITION amino acid permease GAP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012965 VERSION NP_012965.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179829.3 REFERENCE 1 (residues 1 to 602) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 602) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 602) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 602) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09192. On Jul 30, 2012 this sequence version replaced NP_012965.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..602 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..602 /product="amino acid permease GAP1" /calculated_mol_wt="65525" Region 87..566 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..602 /gene="GAP1" /locus_tag="YKR039W" /coded_by="NM_001179829.3:1..1809" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:15039776]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:15039776]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15707981|PMID:15623581|PMID:9199164]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:12499351]" /experiment="EXISTENCE:genetic interaction:GO:0015193 L-proline transmembrane transporter activity [PMID:14968425]" /experiment="EXISTENCE:mutant phenotype:GO:0001761 beta-alanine transmembrane transporter activity [PMID:29570051]" /experiment="EXISTENCE:mutant phenotype:GO:0005771 multivesicular body [PMID:14523026]" /experiment="EXISTENCE:mutant phenotype:GO:0006865 amino acid transport [PMID:6759873]" /experiment="EXISTENCE:mutant phenotype:GO:0015171 amino acid transmembrane transporter activity [PMID:6759873]" /experiment="EXISTENCE:mutant phenotype:GO:0015203 polyamine transmembrane transporter activity [PMID:15707981]" /experiment="EXISTENCE:mutant phenotype:GO:0015846 polyamine transport [PMID:15707981]" /note="General amino acid permease; involved in uptake of all L-amino acids, some D-amino acids, related compounds, toxic analogs and polyamines; regulated by nitrogen source; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; essential for invasive growth" /db_xref="GeneID:853912" /db_xref="SGD:S000001747" ORIGIN 1 msntssyekn npdnlkhngi tidsefltqe pitipsngsa vsidetgsgs kwqdfkdsfk 61 rvkpievdpn lseaekvaii taqtplkhhl knrhlqmiai ggaigtgllv gsgtalrtgg 121 paslligwgs tgtmiyamvm algelavifp isggfttyat rfidesfgya nnfnymlqwl 181 vvlpleivsa sitvnfwgtd pkyrdgfval fwlaiviinm fgvkgygeae fvfsfikvit 241 vvgfiilgii lncgggptgg yiggkywhdp gafagdtpga kfkgvcsvfv taafsfagse 301 lvglaasesv eprksvpkaa kqvfwritlf yilsllmigl lvpyndksli gassvdaaas 361 pfviaikthg ikglpsvvnv viliavlsvg nsaiyacsrt mvalaeqrfl peifsyvdrk 421 grplvgiavt safgliafva askkegevfn wllalsglss lftwggicic hirfrkalaa 481 qgrgldelsf ksptgvwgsy wglfmviimf iaqfyvavfp vgdspsaegf feaylsfplv 541 mvmyighkiy krnwklfipa ekmdidtgrr evdldllkqe iaeekaimat kprwyriwnf 601 wc // LOCUS NP_012967 250 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKR041W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012967 VERSION NP_012967.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179831.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 250) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09193. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..250 /product="uncharacterized protein" /calculated_mol_wt="29077" CDS 1..250 /locus_tag="YKR041W" /coded_by="NM_001179831.1:1..753" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:21777356]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0072686 mitotic spindle [PMID:21777356]" /note="hypothetical protein; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking" /db_xref="GeneID:853914" /db_xref="SGD:S000001749" ORIGIN 1 msdddymnsd ddndaekryv rpifvrkrrr eedyvatskd nihhhpcdws akpsqrqnen 61 eqkstirlvp vamntpkcqe kkkkrkgvgt tsheatlfey gesiagykcv tteserdrlk 121 rshesessse sevdvfafdq akgisskvea eeryaravrq ywrmtkdepa tlplpgtptl 181 aavsldmidd ksveqfytms salmdanrld lirrdrirwh pdkhryhksk vtklfqaing 241 lweqektekr // LOCUS NP_012968 365 aa linear PLN 30-JUN-2025 DEFINITION SUN family protein UTH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012968 VERSION NP_012968.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179832.3 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 365) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09194. On Jul 30, 2012 this sequence version replaced NP_012968.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..365 /product="SUN family protein UTH1" /calculated_mol_wt="36824" Region 111..352 /region_name="SUN" /note="Beta-glucosidase (SUN family); pfam03856" /db_xref="CDD:427547" CDS 1..365 /gene="UTH1" /locus_tag="YKR042W" /coded_by="NM_001179832.3:1..1098" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:23910823]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:15247238]" /experiment="EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:20070376]" /note="Mitochondrial inner membrane protein; role in mitophagy is disputed; implicated in cell wall biogenesis, the oxidative stress response, life span during starvation, and cell death; SUN family member; UTH1 has a paralog, NCA3, that arose from the whole genome duplication" /db_xref="GeneID:853916" /db_xref="SGD:S000001750" ORIGIN 1 mklsallals astavlaapa vhhsdnhhhn dkravvtvtq yvnadgavvi paattatsaa 61 adgkvesvaa atttlsstaa aattsaaass ssssssssss sssvgsgdfe dgtiscsdfp 121 sgqgavsldw lglggwasim dmngntatsc qdgyycsyac spgyaktqwp seqpsdgrsv 181 gglyckngkl yrsntdtnsl cvegqgsaqa vnkvsgsiai cgtdypgsen mvvptvvgag 241 ssqpinvike dsyyqwqgkk tsaqyyvnna gvsvedgciw gtegsgvgnw apvvlgagyt 301 dgitylsiip npnnkeapnf nikivatdgs tvngacsyen gvysgsgsdg ctvsvtsgsa 361 nfvfy // LOCUS NP_012969 271 aa linear PLN 30-JUN-2025 DEFINITION sedoheptulose-bisphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012969 VERSION NP_012969.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179833.1 REFERENCE 1 (residues 1 to 271) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 271) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 271) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 271) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09195. Method: conceptual translation. FEATURES Location/Qualifiers source 1..271 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..271 /product="sedoheptulose-bisphosphatase" /EC_number="3.1.3.37" /calculated_mol_wt="30891" Region 9..192 /region_name="His_Phos_1" /note="Histidine phosphatase superfamily (branch 1); pfam00300" /db_xref="CDD:459751" CDS 1..271 /gene="SHB17" /locus_tag="YKR043C" /coded_by="NM_001179833.1:1..816" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0046390 ribose phosphate biosynthetic process [PMID:21663798]" /experiment="EXISTENCE:direct assay:GO:0050278 sedoheptulose-bisphosphatase activity [PMID:21663798]" /experiment="EXISTENCE:mutant phenotype:GO:0046390 ribose phosphate biosynthetic process [PMID:21663798]" /experiment="EXISTENCE:mutant phenotype:GO:0050278 sedoheptulose-bisphosphatase activity [PMID:21663798]" /note="Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates to pentose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus" /db_xref="GeneID:853917" /db_xref="SGD:S000001751" ORIGIN 1 mpsltprcii vrhgqtewsk sgqytgltdl pltpygegqm lrtgesvfrn nqflnpdnit 61 yiftsprlra rqtvdlvlkp lsdeqrakir vvvdddlrew eygdyegmlt reiielrksr 121 gldkerpwni wrdgcenget tqqiglrlsr aiariqnlhr khqsegrasd imvfahghal 181 ryfaaiwfgl gvqkkcetie eiqnvksydd dtvpyvkles yrhlvdnpcf lldaggigvl 241 syahhnidep alelagpfvs ppeeesqhgd v // LOCUS NP_012970 443 aa linear PLN 30-JUN-2025 DEFINITION Uip5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012970 VERSION NP_012970.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179834.3 REFERENCE 1 (residues 1 to 443) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 443) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 443) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 443) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09196. On Jul 30, 2012 this sequence version replaced NP_012970.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..443 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..443 /product="Uip5p" /calculated_mol_wt="50850" Region 55..320 /region_name="lectin_leg-like" /note="legume-like lectins: ERGIC-53, ERGL, VIP36, VIPL, EMP46, and EMP47; cd07308" /db_xref="CDD:173892" Site order(133,304) /site_type="other" /note="carbohydrate binding site [chemical binding]" /db_xref="CDD:173892" Site 188 /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:173892" CDS 1..443 /gene="UIP5" /locus_tag="YKR044W" /coded_by="NM_001179834.3:1..1332" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11056382]" /note="hypothetical protein that interacts with Ulp1p; a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates" /db_xref="GeneID:853918" /db_xref="SGD:S000001752" ORIGIN 1 msrdvraekl aisllilslf lifqlvaeiy lnngdqyhte tspftrgrsh vtrvpnhdas 61 lsipfldkin qfwhvggatq irniqsiklt qdrdqdkhgl vlsngigdnt indfeivftf 121 rishdpttql tgdgmcfait pengfltqnl qssyakkqym mnsqgviadn tdlmgfpknl 181 pglfivldty rnqghdhkev pfmdvfinva pesdwydins dgelstslrl nsrghiklkk 241 nalwnrvtkl riiylesisf lkidvqyake gnywielfqt tenlylpknm htgqryigcs 301 alngqltetv elldvstsef hwndmdasie dtydyakeae lfleqefgev ldrepdeftk 361 wkmikaqpni ktgsqsaeqk tsnnphsrlf kvvltiwhys eilllimgiy lfsacirvfq 421 rrfkkirsrr kragshsvgl lpm // LOCUS NP_012971 183 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKR045C [Saccharomyces cerevisiae S288C]. ACCESSION NP_012971 VERSION NP_012971.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179835.1 REFERENCE 1 (residues 1 to 183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 183) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09197. On Oct 2, 2003 this sequence version replaced NP_012971.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..183 /product="uncharacterized protein" /calculated_mol_wt="20095" CDS 1..183 /locus_tag="YKR045C" /coded_by="NM_001179835.1:1..552" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /note="hypothetical protein; epitope-tagged protein localizes to the cytoplasm" /db_xref="GeneID:853919" /db_xref="SGD:S000001753" ORIGIN 1 msnshhtsqg rrnklsvwvk kiintttttn asvssskprr gtragptrvk raeldpdgtt 61 issslrplvd rnslhssesd degdrrvawd epptgkvrqq qqqqqqqqnd nasviplvsf 121 csssvksstf sdihsiqstr ptifsnrtfe tnssvlaipp qsildrsrtl ppsnasnttt 181 rrp // LOCUS NP_012972 283 aa linear PLN 30-JUN-2025 DEFINITION Pln1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012972 VERSION NP_012972.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179836.3 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 283) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09198. On Jul 30, 2012 this sequence version replaced NP_012972.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..283 /product="Pln1p" /calculated_mol_wt="31115" Region 18..266 /region_name="Perilipin_2" /note="Perilipin protein; pfam17316" /db_xref="CDD:465405" CDS 1..283 /gene="PLN1" /locus_tag="YKR046C" /gene_synonym="PET10" /coded_by="NM_001179836.3:1..852" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093|PMID:10515935]" /experiment="EXISTENCE:expression pattern:GO:0009060 aerobic respiration [PMID:10618406]" /note="Perilipin, involved in formation and stability of lipid droplets; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange" /db_xref="GeneID:853920" /db_xref="SGD:S000001754" ORIGIN 1 msessisssk psvelpqatw shlqrypals kfikyaeslp pverlisfnl vvlgsvnqwv 61 sessssprlv kqvvaagkeg afkldelvnl lvfkegvdgl lynwkshsnt pgiwlvwffv 121 dyvanisntl lreflikplh lqgstaskei gssgeenkvt dasslphvae lssttrgmsq 181 eiqskvksny idptkdlake kydaivkptt dklqsvyidp tktklnetyq rfttvyennl 241 sksesvpkai vstgldlgna tieklkasre dqtnskpaav stn // LOCUS NP_012974 417 aa linear PLN 30-JUN-2025 DEFINITION histone chaperone NAP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012974 VERSION NP_012974.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179838.1 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 417) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09199. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..417 /product="histone chaperone NAP1" /calculated_mol_wt="47754" Region 95..362 /region_name="NAP" /note="Nucleosome assembly protein (NAP); pfam00956" /db_xref="CDD:460010" CDS 1..417 /gene="NAP1" /locus_tag="YKR048C" /coded_by="NM_001179838.1:1..1254" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:30341817|PMID:7622566]" /experiment="EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:1400414|PMID:2016313]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:22308335]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:25416945]" /experiment="EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:30341817]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:22308335]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:17289584|PMID:21348863]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:31062022]" /experiment="EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:31062022]" /experiment="EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:12456659]" /experiment="EXISTENCE:mutant phenotype:GO:0007117 budding cell bud growth [PMID:13680156]" /experiment="EXISTENCE:mutant phenotype:GO:0031116 positive regulation of microtubule polymerization [PMID:7622567]" /experiment="EXISTENCE:mutant phenotype:GO:0098841 protein localization to cell division site after cytokinesis [PMID:25416945]" /experiment="EXISTENCE:physical interaction:GO:0030332 cyclin binding [PMID:7622566]" /note="Histone chaperone and assembly chaperone for Rps6a/b; involved in histone exchange, replacing histone H2A-H2B dimers or histone variant dimers from assembled nucleosomes; promotes solubility of Rps6a, and 40S ribosomal subunit biogenesis; role in transport of H2A and H2B histones to the nucleus; regulates microtubule dynamics during mitosis; interacts with mitotic cyclin Clb2p; controls bud morphogenesis; phosphorylated by CK2; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853922" /db_xref="SGD:S000001756" ORIGIN 1 msdpirtkpk ssmqidnapt phntpasvln psylkngnpv raqaqeqddk igtineedil 61 anqplllqsi qdrlgslvgq dsgyvgglpk nvkekllslk tlqselfeve kefqvemfel 121 enkflqkykp iweqrsriis gqeqpkpeqi akgqeivesl netellvdee ekaqndseee 181 qvkgipsfwl talenlpivc dtitdrdaev leylqdigle yltdgrpgfk llfrfdssan 241 pfftndilck tyfyqkelgy sgdfiydhae gceiswkdna hnvtvdlemr kqrnkttkqv 301 rtiekitpie sffnffdppk iqnedqdeel eedleerlal dysigeqlkd klipravdwf 361 tgaalefefe edeeeadede deeedddhgl edddgesaee qddfagrpeq apeckqs // LOCUS NP_012975 133 aa linear PLN 30-JUN-2025 DEFINITION putative redox protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_012975 VERSION NP_012975.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179839.3 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 133) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09200. On Jul 30, 2012 this sequence version replaced NP_012975.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..133 /product="putative redox protein" /calculated_mol_wt="15519" Region 4..121 /region_name="DUF1687" /note="Protein of unknown function (DUF1687); pfam07955" /db_xref="CDD:400349" CDS 1..133 /gene="FMP46" /locus_tag="YKR049C" /coded_by="NM_001179839.3:1..402" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0051051 negative regulation of transport [PMID:21912684]" /note="Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:853923" /db_xref="SGD:S000001757" ORIGIN 1 msfwktlqrq prtislftnd iasniksqkc lqllkgdvsh rfdveianrf ptwdqlqymr 61 tscpqgpvsl qrqipkldsv lkykhtdptf gmdlqkcvqr glwnpkealw vdwenklvgn 121 epadidkyii qrk // LOCUS NP_012976 889 aa linear PLN 30-JUN-2025 DEFINITION Trk2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012976 VERSION NP_012976.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179840.1 REFERENCE 1 (residues 1 to 889) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 889) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 889) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 889) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09201. Method: conceptual translation. FEATURES Location/Qualifiers source 1..889 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..889 /product="Trk2p" /calculated_mol_wt="100956" Region 4..839 /region_name="2a38euk" /note="potassium uptake protein, Trk family; TIGR00934" /db_xref="CDD:130009" CDS 1..889 /gene="TRK2" /locus_tag="YKR050W" /gene_synonym="RPD2" /coded_by="NM_001179840.1:1..2670" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:14570869]" /experiment="EXISTENCE:direct assay:GO:0015079 potassium ion transmembrane transporter activity [PMID:2072919]" /experiment="EXISTENCE:direct assay:GO:0030007 intracellular potassium ion homeostasis [PMID:2072919]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:33640956]" /experiment="EXISTENCE:mutant phenotype:GO:0042391 regulation of membrane potential [PMID:21424545]" /note="Component of the Trk1p-Trk2p potassium transport system; contributes to K(+) supply and maintenance of plasma-membrane potential; TRK2 has a paralog, TRK1, that arose from the whole genome duplication" /db_xref="GeneID:853924" /db_xref="SGD:S000001758" ORIGIN 1 mptakrtssr aslalpfqlr lvhkkswghr lrdfisgflk scrpiakyvf pnfivvhyiy 61 litlsiigsi llypckntaf idvlflaaga stqgglatks tndfnlyqqi vvyvitllst 121 pilihgflaf vrlywferyf dnirdiskqn fklrrtmtlq qrelsgssgn aarsrsfkdn 181 lfrgkfvsre dprqsasdvp mdspdtsals sisplnvsss keessdtqss ppnfsskrqp 241 sdvdprdiyk simmlqkqqe ksnanstdsf ssetngpafi vqerherrap hcslkrhsvl 301 pssqelnkla qtksfqkllg lrrdegdhdy fdgaphkymv tkkkkisrtq scniptytas 361 pspktsgqvv enhrnlaksa pssfvdeems fspqeslnlq fqahppkpkr regdighpft 421 rtmstnylsw qptfgrnsvf igltkqqkee lggveyralr llccilmvyy igfnilafvt 481 ivpwactrhh yseiirrngv sptwwgffta msafsnlgls ltadsmvsfd tapyplifmm 541 ffiiigntgf pimlrfiiwi mfktsrdlsq fkeslgflld hprrcftllf psgptwwlft 601 tlvvlnatdw ilfiildfns avvrqvakgy ralmglfqsv ctrtagfnvv dlsklhpsiq 661 vsymlmmyvs vlplaisirr tnvyeeqslg lydsgqdden itheddiket dhdgeseerd 721 tvstkskpkk qspksfvgah lrrqlsfdlw ylflglfiic icegrkiedv nkpdfnvfai 781 lfevvsaygt vglslgypnt ntslsaqftv lsklviiaml irgrnrglpy tldraimlps 841 dkleqidrlq dmkakgklla kvgedpmtty vkkrshklkk iatkfwgkh // LOCUS NP_012977 418 aa linear PLN 30-JUN-2025 DEFINITION Hfl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012977 VERSION NP_012977.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179841.3 REFERENCE 1 (residues 1 to 418) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 418) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 418) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 418) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09202. On Jul 30, 2012 this sequence version replaced NP_012977.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..418 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..418 /product="Hfl1p" /calculated_mol_wt="48626" Region 14..270 /region_name="Solute_trans_a" /note="Organic solute transporter Ostalpha; pfam03619" /db_xref="CDD:460991" CDS 1..418 /gene="HFL1" /locus_tag="YKR051W" /coded_by="NM_001179841.3:1..1257" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:34088313]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0044395 protein targeting to vacuolar membrane [PMID:34088313]" /note="Vacuole membrane protein that interacts with Atg8p; functions in the vacuolar membrane recruitment of Atg8p to facilitate the degradation of vacuolar integral membrane proteins during early-stationary vacuole turnover (EVT), a general degradation process for vacuolar integral membrane proteins when cells enter stationary phase; null mutant is defective in stationary phase-induced vacuolar microdomain formation; homolog of S. pombe hfl1; homolog of human TMEM184" /db_xref="GeneID:853925" /db_xref="SGD:S000001759" ORIGIN 1 menkllcwwl ywpcvyssii atiisfytit rhllnyrkpy eqrlsirill lvpifsvsca 61 sgiikpeaaq fyvdpirefy eafviytfft fltlllgger niitvlslnh aptrhpipli 121 gkickpidls dpfdflfvkk gilqyvwfkp fycfgtlics awklpkfeif lnvfynisvt 181 wslyslalfw kclypeltpy kpwlkflcvk liifasywqs iiiqglvvtg klgtgnqdrt 241 sgyvykngll ciemvpfail havafpwnky tafsipygar mkfiyalkdf lgcgdliwdf 301 kqtlfagply ynyrnfdpea mdllstrqqs gatmerlkhg lrftdngrns ywvaygsidn 361 nlvpesiees weddiagqrt fpedpnypvv hdytmghrys rsmndlrrdv qsrssmac // LOCUS NP_012978 304 aa linear PLN 30-JUN-2025 DEFINITION Fe(2+) transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_012978 VERSION NP_012978.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179842.1 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 304) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09203. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..304 /product="Fe(2+) transporter" /calculated_mol_wt="33177" Region 27..252 /region_name="PTZ00168" /note="mitochondrial carrier protein; Provisional" /db_xref="CDD:185494" Region 205..304 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..304 /gene="MRS4" /locus_tag="YKR052C" /coded_by="NM_001179842.1:1..915" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:1703236]" /experiment="EXISTENCE:direct assay:GO:0048250 iron import into the mitochondrion [PMID:12902335]" /experiment="EXISTENCE:mutant phenotype:GO:0005381 iron ion transmembrane transporter activity [PMID:12902335]" /note="Iron transporter of the mitochondrial carrier family; mediates Fe2+ transport across the inner mitochondrial membrane; active under low-iron conditions; may transport other cations; protein abundance increases in response to DNA replication stress; MRS4 has a paralog, MRS3, that arose from the whole genome duplication" /db_xref="GeneID:853926" /db_xref="SGD:S000001760" ORIGIN 1 mntselsiae eidyealpsh aplhsqllag afagimehsl mfpidalktr vqaaglnkaa 61 stgmisqisk istmegsmal wkgvqsvilg agpahavyfg tyefckarli spedmqthqp 121 mktalsgtia tiaadalmnp fdtvkqrlql dtnlrvwnvt kqiyqnegfa afyysypttl 181 amnipfaafn fmiyesaskf fnpqnsynpl ihclcggisg atcaalttpl dciktvlqvr 241 gsetvsieim kdantfgras railevhgwk gfwrglkpri vanipatais wtayecakhf 301 lmkn // LOCUS NP_012979 404 aa linear PLN 30-JUN-2025 DEFINITION sphinganine kinase YSR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012979 VERSION NP_012979.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179843.3 REFERENCE 1 (residues 1 to 404) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 404) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 404) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 404) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09204. On Jul 30, 2012 this sequence version replaced NP_012979.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..404 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..404 /product="sphinganine kinase YSR3" /calculated_mol_wt="46357" Region 77..231 /region_name="PAP2_SPPase1" /note="PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second...; cd03388" /db_xref="CDD:239482" Site order(129,136,159..161,205,211,215) /site_type="active" /db_xref="CDD:239482" CDS 1..404 /gene="YSR3" /locus_tag="YKR053C" /gene_synonym="LBP2" /coded_by="NM_001179843.3:1..1215" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10477278|PMID:10531356]" /experiment="EXISTENCE:direct assay:GO:0042392 sphingosine-1-phosphate phosphatase activity [PMID:10856228]" /experiment="EXISTENCE:direct assay:GO:0046839 phospholipid dephosphorylation [PMID:10856228]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:9353337]" /note="Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication" /db_xref="GeneID:853927" /db_xref="SGD:S000001761" ORIGIN 1 mtiiqtvtel gvtedtikvq mapsggkhll adpgnhpaeh fesqmswlrf qtrqyltrft 61 dnqsdfvhsl qkkhrtpfrd vyfkytslmg shmfyvivlp mpvwlgyrdl trdmiyvlgy 121 siylsgylkd ywclprpksp pvdritlsey ttkeygapss hsanatavsl lffwriclsd 181 tlvwptklll lslvifyylt lvfgrvycgm hgmldlfsga avgaicffir iwvvhalrnf 241 qigehlwfpl lsvawglfil fnhvrpidec pcfedsvafi gvvsgldcsd wlterygwnl 301 vcsryascgs kvflrplvgv asvivwkdvi sktavytlli kllrfhddrs ekvhfhnets 361 eeeecllysg vskveivgrf liyagipttv fllcpvfftw tnlr // LOCUS NP_012980 4092 aa linear PLN 30-JUN-2025 DEFINITION dynein heavy chain [Saccharomyces cerevisiae S288C]. ACCESSION NP_012980 VERSION NP_012980.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179844.1 REFERENCE 1 (residues 1 to 4092) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 4092) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 4092) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 4092) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 4092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 4092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 4092) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09205. Method: conceptual translation. FEATURES Location/Qualifiers source 1..4092 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..4092 /product="dynein heavy chain" /calculated_mol_wt="471219" Region 219..763 /region_name="DHC_N1" /note="Dynein heavy chain, N-terminal region 1; pfam08385" /db_xref="CDD:462457" Region 774..4083 /region_name="DYN1" /note="Dynein, heavy chain [Cytoskeleton]; COG5245" /db_xref="CDD:227570" CDS 1..4092 /gene="DYN1" /locus_tag="YKR054C" /gene_synonym="DHC1; PAC6" /coded_by="NM_001179844.1:1..12279" /experiment="EXISTENCE:direct assay:GO:0000235 astral microtubule [PMID:16580990]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:25941405]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:16580990]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:15965467|PMID:12566428]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:15642746]" /experiment="EXISTENCE:direct assay:GO:0008569 minus-end-directed microtubule motor activity [PMID:25941405|PMID:16873064]" /experiment="EXISTENCE:genetic interaction:GO:0000070 mitotic sister chromatid segregation [PMID:7860634]" /experiment="EXISTENCE:genetic interaction:GO:0030473 nuclear migration along microtubule [PMID:9201714]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:9281582]" /experiment="EXISTENCE:mutant phenotype:GO:0008569 minus-end-directed microtubule motor activity [PMID:25941405]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:9201714]" /experiment="EXISTENCE:mutant phenotype:GO:0040001 establishment of mitotic spindle localization [PMID:21633107]" /experiment="EXISTENCE:physical interaction:GO:0005868 cytoplasmic dynein complex [PMID:9658168]" /note="Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p" /db_xref="GeneID:853928" /db_xref="SGD:S000001762" ORIGIN 1 mcknearlan eliefvaatv tgiknspken eqafidylhc qylerfqffl glldgrefdt 61 lfvflfeeld rtivtidige eaiydanlan kkystlliik srsvivdaep iatqisaiyl 121 pgpvnagnla siithgvssv fgqliksdtk tysvetidkt rrklddiskq fqqlhtsiet 181 pdllamvpsi iklavskgat shdyanylps ndlesmrfln ilqsiankwf lvlkqtlaid 241 rdikngsfld evefwsnfye vlkslieqtq sqefqvclsv ltnakrfhnl tnllnegsls 301 dkfkladkyn qflssipide vrqasnledl qelfpvlass lkkfrysgyp vqrfvvlmdk 361 isqevmdail snlsdlfqle ygsflglyek sagmieewdd ivqdvnllir edlrkrapqe 421 lliqkltfts asvkatldei lstrkrffsl aetiksisps tyheeiqrly hpfeqihdis 481 vnfrlkleqa esefsknmld lekklqntla sfmdsdhcpt eklsylvkfk plmelcprik 541 vkvlenqqil lleikkdirq letglellpk ilhvealnni ppisarisyf lnvqsridni 601 vqylealfgs nwndtlegrs istsivqlrk etnphdvflh wlgnfpekat anllttpilk 661 lirnneddye lkvnfdfala aayselrslt ymafqvpshi vriartymyl yprainlvel 721 iqtffslsks lsytfytnif lkrnvqtvwl llqqilitpw eslqeessem scsvhslarl 781 eksidgilsd yqilknsepq fakefsglks fdgtaddlhe veeiisniqa ifenlftkgl 841 tnvsdhistf nnliisiile kvrlnlkkmh fpkhvlklsf negritssps laamkrsllk 901 dieallnkvv linflhdpdh plsttltfns lviklkddiq ncieqvqnlh ckinsyvkew 961 qkmeflwqit eeaflevvdn stqrcfgilk glldsqskfd liisrnnfsk nlvlhtedaq 1021 rhirskmdsw ilyvskhllt iyerdarklh edmnrdreav edmdinftsl knitviieav 1081 nvnkrhlter diqikllgsv mraltklkvr fpshfvyidq ldndfsslrq slsyveqelq 1141 khrvviaksl eegveninnl sqslneswsv rkpisptltp pealkileff nesitklkkk 1201 mhsvaaaakm llipvvlndq lthvveevkt ydlvwrsikn lwedvqrtfe tpwcrvdvll 1261 lqsdlanflr radelpravk qfemykslfs qvnmltsvnk ilvelkdgal kprhwnmifr 1321 digkrqiqkn lldklefslk dvmvlnltln eilltkiier aqkefvieks lnrikkfwke 1381 aqyeviehss glklvrewdv leqackedle elvsmkasny ykifeqdcld leskltklse 1441 iqvnwvevqf ywldlygilg enldiqnflp letskfkslt seykmittra fqldttievi 1501 hipnfdttlk ltidslkmik sslstflerq rrqfprfyfl gnddllkiig sgkhhdqvsk 1561 fmkkmfgsie siifledfit gvrsvegevl nlnekielkd siqaqewlni ldteiklsvf 1621 tqfrdclgql kdgtdievvv skyifqaill saqvmwtelv ekclqtnqfs kywkevdmki 1681 kglldklnks sdnvkkkiea llveylhfnn vigqlkncst keearllwak vqkfyqkndt 1741 lddlnsvfis qsgyllqykf eyigiperli ytpllligfa tltdslhqky ggcffgpagt 1801 gktetvkafg qnlgrvvvvf ncddsfdyqv lsrllvgitq igawgcfdef nrldekvlsa 1861 vsaniqqiqn glqvgkshit lleeetplsp htavfitlnp gyngrselpe nlkksfrefs 1921 mkspqsgtia emilqimgfe dskslaskiv hflellsskc ssmnhyhfgl rtlkgvlrnc 1981 splisefgeg ektvveslkr vilpslgdtd elvfkdelsk ifdsagtpln skaivqclkd 2041 agqrsgfsms eeflkkcmqf yymqktqqal ilvgkagcgk tatwktvida maifdghanv 2101 vyvidtkvlt keslygsmlk atlewrdglf tsilrrvndd itgtfknsri wvvfdsdldp 2161 eyveamnsvl ddnkiltlpn gerlpippnf rilfetdnld httpatitrc gllwfstdvc 2221 sisskidhll nksyealdnk lsmfeldklk dlisdsfdma sltniftcsn dlvhilgvrt 2281 fnkletavql avhlissyrq wfqnlddksl kdvitllikr sllyalagds tgesqrafiq 2341 tintyfghds qelsdystiv iandklsfss fcseipsvsl eahevmrpdi viptidtikh 2401 ekifydllns krgiilcgpp gsgktmimnn alrnsslydv vginfskdtt tehilsalhr 2461 htnyvttskg ltllpksdik nlvlfcdein lpkldkygsq nvvlflrqlm ekqgfwktpe 2521 nkwvtierih ivgacnpptd pgripmserf trhaailylg ypsgkslsqi yeiyykaifk 2581 lvpefrsyte pfarasvhly neckarystg lqshylfspr eltrlvrgvy taintgprqt 2641 lrslirlway eawrifadrl vgvkeknsfe qllyetvdky lpnqdlgnis stsllfsgll 2701 sldfkevnkt dlvnfieerf ktfcdeelev pmvihesmvd hilridralk qvqghmmlig 2761 asrtgktilt rfvawlnglk ivqpkihrhs nlsdfdmilk kaisdcslke srtcliides 2821 niletafler mntllanadi pdlfqgeeyd kllnnlrnkt rslgllldte qelydwfvge 2881 iaknlhvvft icdptnnkss amisspalfn rciinwmgdw dtktmsqvan nmvdvipmef 2941 tdfivpevnk elvftepiqt irdavvnili hfdrnfyqkm kvgvnprspg yfidglralv 3001 klvtakyqdl qenqrfvnvg leklnesvlk vnelnktlsk ksteltekek earstldkml 3061 meqneserkq eateeikkil kvqeedirkr kevvmksiqd ieptileaqr gvknikkqql 3121 teirsmvnpp sgvkivmeav cailgyqfsn wrdiqqfirk ddfihnivhy dttlhmkpqi 3181 rkymeeefls dpnftyetin raskacgply qwvnaqinfs kvlenvdplr qemkriefes 3241 lktkanllaa eemtqdleas ievskrkysl lirdveaikt emsnvqanld rsislvkslt 3301 fekerwlntt kqfsktsqel ignciissiy etyfghlner eradmlvilk rllgkfavky 3361 dvnyrfidyl vtldekmkwl ecgldkndyf lenmsivmns qdavpflldp sshmitvisn 3421 yygnktvlls fleegfvkrl enairfgsvv iiqdgeffdp iisrlisref nhagnrvtve 3481 igdhevdvsg dfklfihscd psgdipiflr srvrlvhfvt nkesietrif ditlteenae 3541 mqrkredlik lnteyklklk nlekrlleel nnsqgnmlen delmvtlnnl kkeamniekk 3601 lseseeffpq fdnlveeysi igkhsvkifs mlekfgqfhw fygisigqfl scfkrvfikk 3661 sretraartr vdeilwllyq evycqfstal dkkfkmimam tmfclykfdi eseqykeavl 3721 tmigvlsess dgvpkltvdt nndlrylwdy vttksyisal nwfkneffvd ewniadvvan 3781 sennyftmas erdvdgtfkl ielakaskes lkiiplgsie nlnyaqeeis kskieggwil 3841 lqniqmslsw vktylhkhve etkaaeehek fkmfmtchlt gdklpapllq rtdrfvyedi 3901 pgildtvkdl wgsqfftgki sgvwsvyctf llswfhalit artrlvphgf skkyyfndcd 3961 fqfasvylen vlatnstnni pwaqvrdhia tivyggkide ekdlevvakl cahvfcgsdn 4021 lqivpgvrip qpllqqseee erarltails ntiepadsls swlqlpresi lnyerlqake 4081 vassteqllq em // LOCUS NP_012981 291 aa linear PLN 30-JUN-2025 DEFINITION Rho family GTPase RHO4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012981 VERSION NP_012981.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179845.3 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 291) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09206. On Jul 30, 2012 this sequence version replaced NP_012981.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..291 /product="Rho family GTPase RHO4" /EC_number="3.6.5.2" /calculated_mol_wt="32055" Region 70..248 /region_name="Rho4_like" /note="Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like; cd04132" /db_xref="CDD:206704" Site order(74,104..105,108..109,111,113,122,126..127,129..131, 137,140) /site_type="other" /note="putative GEF (guanine nucleotide exchange factor) interaction site [polypeptide binding]" /db_xref="CDD:206704" Site 79..86 /site_type="other" /note="G1 box" /db_xref="CDD:206704" Site order(82..87,127..128,130,186,188,221..222) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206704" Site 103..109 /site_type="other" /note="Switch I region" /db_xref="CDD:206704" Site 104 /site_type="other" /note="G2 box" /db_xref="CDD:206704" Site order(105,129,137,139) /site_type="active" /note="putative GDI (guanine nucleotide dissociation inhibitor) interaction [active]" /db_xref="CDD:206704" Site order(105..106,131,137) /site_type="other" /note="putative GAP (GTPase-activating protein) interaction site [polypeptide binding]" /db_xref="CDD:206704" Site order(106..107,137,140) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206704" Site 127..130 /site_type="other" /note="G3 box" /db_xref="CDD:206704" Site order(130..131,137..140,145..147) /site_type="other" /note="Switch II region" /db_xref="CDD:206704" Site 185..188 /site_type="other" /note="G4 box" /db_xref="CDD:206704" Site 220..222 /site_type="other" /note="G5 box" /db_xref="CDD:206704" CDS 1..291 /gene="RHO4" /locus_tag="YKR055W" /coded_by="NM_001179845.3:1..876" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:18417612]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:10526184]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18417612]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:18417612]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:1448099]" /experiment="EXISTENCE:genetic interaction:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:12810699]" /experiment="EXISTENCE:physical interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:9184220]" /note="Non-essential small GTPase; member of the Rho/Rac subfamily of Ras-like proteins; likely to be involved in the establishment of cell polarity; has long N-terminal extension that plays an important role in Rho4p function and is shared with Rho4 homologs in other yeasts and filamentous fungi" /db_xref="GeneID:853929" /db_xref="SGD:S000001763" ORIGIN 1 mntllfkrkg gncgnesniv sqgspsssnl pespgtldek nlprlptpfa rslstipsye 61 qmkrtnklpd yhlkivvvgd gavgktclli syvqgtfptd yiptifenyv tniegpngqi 121 ielalwdtag qeeysrlrpl sytnadvlmv cysvgsktsl knvedlwfpe vkhfcpstpi 181 mlvglksdly eadnlsdlve pssaeslakr lgafahiqcs arlkenidev fetaihtlls 241 dslyaprept htiknpfkrn ttrsdidsst gdtsvsisgt krlrknkcii m // LOCUS NP_012982 639 aa linear PLN 30-JUN-2025 DEFINITION tRNA (uracil(54)-C(5))-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012982 VERSION NP_012982.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179846.1 REFERENCE 1 (residues 1 to 639) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 639) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 639) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 639) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09207. On Feb 23, 2004 this sequence version replaced NP_012982.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..639 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..639 /product="tRNA (uracil(54)-C(5))-methyltransferase" /EC_number="2.1.1.35" /calculated_mol_wt="72722" Region 171..637 /region_name="TrmA" /note="tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; COG2265" /db_xref="CDD:441866" CDS 1..639 /gene="TRM2" /locus_tag="YKR056W" /gene_synonym="NUC2; NUD1; RNC1" /coded_by="NM_001179846.1:1..1920" /experiment="EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:17205207]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:10864043]" /experiment="EXISTENCE:direct assay:GO:0030697 tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent [PMID:10864043]" /experiment="EXISTENCE:direct assay:GO:0051908 double-stranded DNA 5'-3' DNA exonuclease activity [PMID:17205207]" /experiment="EXISTENCE:mutant phenotype:GO:0030697 tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent [PMID:10864043]" /note="tRNA methyltransferase; 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; endo-exonuclease with a role in DNA repair" /db_xref="GeneID:853930" /db_xref="SGD:S000001764" ORIGIN 1 myeqfefsff ffensdnkvk ykahlissik rwsiitcmrc fwtvqksifk arffacrnfv 61 kkhnyklist mtgstemvpp tmkhtvdnkr lsspltdsgn rrtkkpklrk ykakkvetts 121 pmgvlefevn dllksqnlsr eqvlndvtsi lndksstdgp ivlqyhrevk nvkvleitsn 181 gnglalidnp vetekkqvvi ipfglpgdvv nikvfkthpy yvesdlldvv ekspmrrddl 241 irdkyfgkss gsqlefltyd dqlelkrkti mnaykffapr lvaekllppf dttvasplqf 301 gyrtkitphf dmpkrkqkel svrpplgfgq kgrpqwrkdt ldigghgsil didecvlate 361 vlnkgltner rkfeqefkny kkgatillre nttildpskp tleqlteeas rdengdisyv 421 evedkknnvr laktcvtnpr qivteyvdgy tfnfsageff qnnnsilpiv tkyvrdnlqa 481 pakgddnktk flvdaycgsg lfsicsskgv dkvigveisa dsvsfaekna kangvencrf 541 ivgkaeklfe sidtpsents vildpprkgc delflkqlaa ynpakiiyis cnvhsqardv 601 eyflketeng sahqiesirg fdffpqthhv esvcimkri // LOCUS NP_012983 87 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS21 RPS21A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012983 VERSION NP_012983.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179847.3 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 87) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09208. On Jul 30, 2012 this sequence version replaced NP_012983.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..87 /product="40S ribosomal protein eS21 RPS21A" /calculated_mol_wt="9615" Region 1..80 /region_name="Ribosomal_S21e" /note="Ribosomal protein S21e; pfam01249" /db_xref="CDD:460133" CDS 1..87 /gene="RPS21A" /locus_tag="YKR057W" /gene_synonym="RPS25" /coded_by="NM_001179847.3:1..264" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /experiment="EXISTENCE:mutant phenotype:GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication" /db_xref="GeneID:853931" /db_xref="SGD:S000001765" ORIGIN 1 mendkgqlve lyvprkcsat nriikaddha svqinvakvd eegraipgey vtyalsgyvr 61 srgesddsln rlaqndgllk nvwsysr // LOCUS NP_012984 616 aa linear PLN 30-JUN-2025 DEFINITION glycogenin glucosyltransferase GLG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012984 VERSION NP_012984.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179848.1 REFERENCE 1 (residues 1 to 616) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 616) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 616) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 616) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09209. On Dec 12, 2005 this sequence version replaced NP_012984.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..616 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..616 /product="glycogenin glucosyltransferase GLG1" /EC_number="2.4.1.186" /calculated_mol_wt="69593" Region 6..279 /region_name="GT8_Glycogenin" /note="Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen; cd02537" /db_xref="CDD:133018" Site order(100..101,104,118,120..122,150,158..160,188..189, 225..226,247,249..250,253) /site_type="active" /note="substrate binding site [active]" /db_xref="CDD:133018" Site order(120,122,247) /site_type="active" /note="Manganese binding site [active]" /db_xref="CDD:133018" Site order(149..150,189,216,218..219,223,227) /site_type="active" /note="dimer interface [active]" /db_xref="CDD:133018" Region <291..>424 /region_name="PRK13914" /note="invasion associated endopeptidase" /db_xref="CDD:237555" CDS 1..616 /gene="GLG1" /locus_tag="YKR058W" /coded_by="NM_001179848.1:1..1851" /experiment="EXISTENCE:genetic interaction:GO:0005978 glycogen biosynthetic process [PMID:8524228]" /experiment="EXISTENCE:genetic interaction:GO:0008466 glycogenin glucosyltransferase activity [PMID:8524228]" /note="Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole respectively; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication" /db_xref="GeneID:853932" /db_xref="SGD:S000001766" ORIGIN 1 mykklaiatl lysadylpgv falghqvnkl leeagkkgdi etclivttsl fngtlselak 61 nilqsiytki vlveplncqe esiqknsenl allerpelsf alikarlwel tqfeqvlyld 121 sdtlplnkef lklfdimskq ttsqvgaiad igwpdmfnsg vmmlipdadt asvlqnyife 181 ntsidgsdqg ilnqffnqnc ctdelvkdsf srewvqlsft ynvtipnlgy qsspamnyfk 241 psiklihfig khkpwslwsq knfikneyhd qwnevyeefk eehqlnnevs kpkisdsdkt 301 etpetitpvd appsnepttn qeidtistve envdnqnaep vpnsdhspap npvpldftkw 361 lttfinkdhl tnqpvnesre yskendnnii nsssnrdqes ppnstqelns sysvvstqad 421 sdehqnaeee dsttdnasns geeshlddis taassnnnvs nqpdgknfsn skennisves 481 spsnpeqkrs tdniqkpsvs tndlpddvep htsvddniqy lekdkegyee flpdvyesna 541 idneeeffdd dardateget ktsavadkqe dmkltaeetn qpqqempnfk fdwedsdyls 601 kvercfpddi feyave // LOCUS NP_012985 395 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF4A [Saccharomyces cerevisiae S288C]. ACCESSION NP_012985 VERSION NP_012985.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179849.3 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 395) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09210. On Jul 30, 2012 this sequence version replaced NP_012985.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..395 /product="translation initiation factor eIF4A" /calculated_mol_wt="44566" Region 10..394 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Site order(24,42,44,49,68..74) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350804" Site order(25,35,38,43) /site_type="other" /note="eIF4G interface [polypeptide binding]" /db_xref="CDD:350804" CDS 1..395 /gene="TIF1" /locus_tag="YKR059W" /coded_by="NM_001179849.3:1..1188" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:1502180]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:1502180]" /note="Translation initiation factor eIF4A; DEAD-box RNA helicase that couples ATPase activity to mRNA binding and unwinding; ATP hydrolysis accelerates the recruitment of mRNA during 48S preinitiation complex (PIC) assembly; ATPase activity stimulated by either eIF4G1 or by the PIC in an eIF3g and eIFGi subunit-dependent manner, independent of eIF4E and eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) with eIF4E and eIF4G; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853933" /db_xref="SGD:S000001767" ORIGIN 1 msegitdiee sqiqtnydkv vykfddmeld enllrgvfgy gfeepsaiqq raimpiiegh 61 dvlaqaqsgt gktgtfsiaa lqridtsvka pqalmlaptr elalqiqkvv malafhmdik 121 vhaciggtsf vedaeglrda qivvgtpgrv fdniqrrrfr tdkikmfild eademlssgf 181 keqiyqiftl lppttqvvll satmpndvle vttkfmrnpv rilvkkdelt legikqfyvn 241 veeeeykyec ltdlydsisv tqavifcntr rkveelttkl rndkftvsai ysdlpqqerd 301 timkefrsgs srilistdll argidvqqvs lvinydlpan kenyihrigr ggrfgrkgva 361 infvtnedvg amrelekfys tqieelpsdi atlln // LOCUS NP_012986 274 aa linear PLN 30-JUN-2025 DEFINITION Utp30p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012986 VERSION NP_012986.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179850.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 274) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09211. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..274 /product="Utp30p" /calculated_mol_wt="31485" Region 31..249 /region_name="Ribosomal_L1" /note="Ribosomal protein L1p/L10e family; pfam00687" /db_xref="CDD:459905" CDS 1..274 /gene="UTP30" /locus_tag="YKR060W" /coded_by="NM_001179850.1:1..825" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:physical interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:21724601]" /note="Subunit of U3-containing 90S preribosome complex; complex is involved in production of 18S rRNA and assembly of small ribosomal subunit; Utp30p is peripherally associated with 90S preribosome and appears partially redundant with its paralog Cic1p" /db_xref="GeneID:853934" /db_xref="SGD:S000001768" ORIGIN 1 mvesndiiks glaekalkal ilqceenpsl kndkdihiii ntgkkmginr dnipriiplt 61 kyklfkprdl nillitkdps alyretltkd ehtselfkei isvknlrrrf kgskltqlyk 121 dfdlvvadyr vhhllpevlg srfyhgskkl pymirmskev klkrqqmvek cdpiyvraql 181 rsickntsyi pnndnclsvr vgyiqkhsip eilqniqdti nfltdkskrp qggvikggii 241 sifvktsnst slpiyqfsea renqknedls dikl // LOCUS NP_012987 425 aa linear PLN 30-JUN-2025 DEFINITION mannosyltransferase KTR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012987 VERSION NP_012987.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179851.3 REFERENCE 1 (residues 1 to 425) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 425) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 425) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 425) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09212. On Jul 30, 2012 this sequence version replaced NP_012987.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..425 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..425 /product="mannosyltransferase KTR2" /calculated_mol_wt="50520" Region 6..424 /region_name="KTR1" /note="Mannosyltransferase [Carbohydrate transport and metabolism]; COG5020" /db_xref="CDD:227353" CDS 1..425 /gene="KTR2" /locus_tag="YKR061W" /coded_by="NM_001179851.3:1..1278" /experiment="EXISTENCE:direct assay:GO:0000030 mannosyltransferase activity [PMID:8631921]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8631921]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:8631921]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:8631921]" /note="Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication" /db_xref="GeneID:853935" /db_xref="SGD:S000001769" ORIGIN 1 mqickvfltq vkkllfvsll fcliaqtcwl alvpyqrqls ldsyffrrsr evssrydftr 61 rrhmnqtlkl ssntyndepl nktkgiknqr enatllmlvr nwelsgalrs mrsledrfnk 121 nyqydwtfln dvpfdqefie attamasgrt qyalipaedw nrpswinetl feealqlmee 181 knilyggsks yrnmcrfnsg fffrqkildp ydfyfrvepd veyfcdfpyd pfkvmrqnnk 241 kygfvitmye yedtipslwe aveeyleete sadidmesna fgfvsnfdfi gksfgvidsn 301 sgynlchfwt nfeigdlnff rsekyirffe yldskggfyy erwgdapvhs iaaslllkkd 361 eiihfdelgy khmpfgtcps ayylrlqqrc lcdsnhpdni dlnvisclrr wwkdgsgkyf 421 lkhds // LOCUS NP_012988 328 aa linear PLN 30-JUN-2025 DEFINITION transcription factor TFIIE subunit TFA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012988 VERSION NP_012988.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179852.1 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 328) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09213. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..328 /product="transcription factor TFIIE subunit TFA2" /calculated_mol_wt="36854" Region 1..328 /region_name="TFA2" /note="Transcription initiation factor IIE, beta subunit [Transcription]; COG5174" /db_xref="CDD:227501" CDS 1..328 /gene="TFA2" /locus_tag="YKR062W" /coded_by="NM_001179852.1:1..987" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:8702741]" /experiment="EXISTENCE:direct assay:GO:0001097 TFIIH-class transcription factor complex binding [PMID:8702741]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:9271406]" /experiment="EXISTENCE:direct assay:GO:0005673 transcription factor TFIIE complex [PMID:1429681|PMID:7961670]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:7961670|PMID:1429681|PMID:1331084]" /experiment="EXISTENCE:direct assay:GO:0097550 transcription preinitiation complex [PMID:22751016]" /experiment="EXISTENCE:genetic interaction:GO:0006366 transcription by RNA polymerase II [PMID:9405484]" /experiment="EXISTENCE:physical interaction:GO:0005673 transcription factor TFIIE complex [PMID:9188494]" /note="TFIIE small subunit; involved in RNA polymerase II transcription initiation" /db_xref="GeneID:853936" /db_xref="SGD:S000001770" ORIGIN 1 msknrdplla nlnafkskvk sapviapakv gqkktndtvi tidgntrkrt aseraqentl 61 nsaknpvlvd ikkeagsnss naislddddd dedfgsspsk kvrpgsiaaa alqanqtdis 121 kshdsskllw ateyiqkkgk pvlvnelldy lsmkkddkvi ellkkldrie fdpkkgtfky 181 lstydvhsps ellkllrsqv tfkgisckdl kdgwpqcdet inqleedski lvlrtkkdkt 241 pryvwynsgg nlkcideefv kmwenvqlpq faelprklqd lglkpasvdp atikrqtkrv 301 evkkkrqrkg kitnthmtgi lkdyshrv // LOCUS NP_012989 502 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein LAS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012989 VERSION NP_012989.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179853.3 REFERENCE 1 (residues 1 to 502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 502) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09214. On Jul 30, 2012 this sequence version replaced NP_012989.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..502 /product="rRNA-processing protein LAS1" /calculated_mol_wt="59221" Region 7..161 /region_name="Las1" /note="Las1-like; pfam04031" /db_xref="CDD:461138" CDS 1..502 /gene="LAS1" /locus_tag="YKR063C" /coded_by="NM_001179853.3:1..1509" /experiment="EXISTENCE:direct assay:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:26638174]" /experiment="EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:26638174]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8582632|PMID:22083961]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:23175604]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22083961]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23175604]" /experiment="EXISTENCE:mutant phenotype:GO:0000460 maturation of 5.8S rRNA [PMID:22083961]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22083961]" /experiment="EXISTENCE:physical interaction:GO:0030687 preribosome, large subunit precursor [PMID:23175604]" /note="Endonuclease involved in pre-rRNA processing at both ends of ITS2; functions with Grc3p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S cell cycle transition; human ortholog is Las1L; mutants require the SSD1-v allele for viability" /db_xref="GeneID:853937" /db_xref="SGD:S000001771" ORIGIN 1 mipprivpwr dfaeleelkl wfypkskgti edkrqravqr vqsyrlkgsq ylphvvdsta 61 qitcavllde keaclgvhqd sipirlsyvm alirfvngll dptqqsqfai plhtlaakig 121 lpswfvdlrh wgtherdlpg lemlrwaane alswlydhyw ndeeleddrd dddddddtgy 181 gyrrndklek ymesltktld kwkrlrnefl eykwvwenan dslitssnfs gdnlvnydae 241 krksshasss etmirenlrq wqelwklsiy hnvvlekffn nydplllkvl mlnlnnfdwk 301 viewvarnyr tqqddsnitt ilkrkfnawk elqkrlldvi innlnnknfk nkwqnwekli 361 denasylily fcqsmlakle tekitgnswr nkkrrkqids tveieaklke nidnlslrfn 421 egeiklydfi paekdsvplk kevspalkad tndilgdlas lkqrmssfgt vgkknkqeen 481 ratpvknwsr vqnwkpkpfg vl // LOCUS NP_012990 863 aa linear PLN 30-JUN-2025 DEFINITION Oaf3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012990 VERSION NP_012990.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179854.1 REFERENCE 1 (residues 1 to 863) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 863) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 863) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 863) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 863) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 863) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 863) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09215. Method: conceptual translation. FEATURES Location/Qualifiers source 1..863 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..863 /product="Oaf3p" /calculated_mol_wt="101695" Region 13..54 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(14,18,23..26,28,31,40) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(19,22,29,35,38,47) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..863 /gene="OAF3" /locus_tag="YKR064W" /coded_by="NM_001179854.1:1..2592" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17551510]" /experiment="EXISTENCE:mutant phenotype:GO:0071400 cellular response to oleic acid [PMID:17551510]" /note="Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:853938" /db_xref="SGD:S000001772" ORIGIN 1 mgydsqvrtk krhritvvct nckkrkskcd rtkpcgtcvr lgdvdscvyl tdssgqpess 61 pslndadplr kqstpaeris pgfikkrrss qtrqdedhwq rvrelenqss lyylpiheet 121 pffidlipng fyletkrsad nlfglftdra ienrdpylqa mvtfrsiaik kmmdklgsng 181 nnvkngslpk sfealstfda dderhisddv vgkgnnfrmh qtihkslfnk faqyrennak 241 kfssetilak dylpplkile sevlalfeek iynmipifdm kvlrheitif yqnivekgnp 301 isikhydhmv fciilliiki crlsvqfskl tpyiypvlqe idtskflalv khylfetkvl 361 rkcnllqlqc lillrflhwc apedgdgpet qycqilmgti issckemgin wycfshpeky 421 sfkinrhtrp sydimkpsdy isvfrkiwsy vlfwdrkmcf isgeecqigk tlqchfkeea 481 dtptwyirml tldnlmkkin dtlnddpgkv dlnllhrlin dlkrnfhilk slskneketm 541 rhfdfemewi idlfslsllh gemifyeydc nitkfyksfq dlwdmvihis ekcynyffns 601 dalevdsltk fytnriveiv ankvlvivpa filrgdrfkt iqyadkkkmi eflygvssvy 661 fnefgfeyyr cfrkmftaki aykilnrsce kdawriilkf llnelkledn gdsyidyndm 721 rlndicpiil efqetvqkyd gyrpdilsiw nnefypigky nddmtgfkfq mrikemqefl 781 dmekysdrfn ifssfydhas sqlakhtevd tnisitneqv aeipqkellq qplapalpvn 841 dlivsefdvi edifdpvdfv sff // LOCUS NP_012991 197 aa linear PLN 30-JUN-2025 DEFINITION Pam17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_012991 VERSION NP_012991.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179855.3 REFERENCE 1 (residues 1 to 197) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 197) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 197) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09216. On Jul 30, 2012 this sequence version replaced NP_012991.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..197 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..197 /product="Pam17p" /calculated_mol_wt="21837" Region 38..195 /region_name="Pam17" /note="Mitochondrial import protein Pam17; pfam08566" /db_xref="CDD:400743" CDS 1..197 /gene="PAM17" /locus_tag="YKR065C" /gene_synonym="FMP18" /coded_by="NM_001179855.3:1..594" /experiment="EXISTENCE:direct assay:GO:0001405 PAM complex, Tim23 associated import motor [PMID:16107694]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:16107694]" /note="Constituent of the TIM23 complex; proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 (Translocase of the Inner mitochondrial Membrane) complex; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:853939" /db_xref="SGD:S000001773" ORIGIN 1 mftsairlss qrlfasqpsv taaalrstat tlplrsysqp aslqdssilt wsdffklrkq 61 qrrinvgssl ftallgcnvs waylstmeid ptqmlfgfdp ltvisagiia sgalgyllgp 121 ivgsqvfkls hnqqlaqfnn knkeflkhii nnrvdassqs fsnpvpdyyg ekigslkeyk 181 qwlrdchaya kkakefl // LOCUS NP_012992 361 aa linear PLN 30-JUN-2025 DEFINITION cytochrome-c peroxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012992 VERSION NP_012992.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179856.1 REFERENCE 1 (residues 1 to 361) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 361) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 361) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 361) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09217. Method: conceptual translation. FEATURES Location/Qualifiers source 1..361 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..361 /product="cytochrome-c peroxidase" /EC_number="1.11.1.5" /calculated_mol_wt="40222" Region 74..344 /region_name="ascorbate_peroxidase" /note="Ascorbate peroxidases and cytochrome C peroxidases; cd00691" /db_xref="CDD:173825" Site order(111..112,115,118,212..214,225,238..239,241..242, 244..248,251..252,258,299,301,329,333) /site_type="other" /note="heme binding site [chemical binding]" /db_xref="CDD:173825" Site order(189,242,244..245,247,272,296..297) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:173825" Site order(243,259,261,264,266,268) /site_type="other" /note="K+ binding site [ion binding]" /db_xref="CDD:173825" CDS 1..361 /gene="CCP1" /locus_tag="YKR066C" /coded_by="NM_001179856.1:1..1086" /experiment="EXISTENCE:direct assay:GO:0004130 cytochrome-c peroxidase activity [PMID:21334283|PMID:17580971]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:6290489]" /experiment="EXISTENCE:mutant phenotype:GO:0004130 cytochrome-c peroxidase activity [PMID:10589830|PMID:21334283]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10589830]" /note="Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria; acts as hydrogen peroxide sensor in mitochondria, involved in the response to oxidative stress" /db_xref="GeneID:853940" /db_xref="SGD:S000001774" ORIGIN 1 mttavrllps lgrtahkrsl ylfsaaaaaa aaatfaysqs qkrsssspgg gsnhgwnnwg 61 kaaalasttp lvhvasvekg rsyedfqkvy naialklred deydnyigyg pvlvrlawht 121 sgtwdkhdnt ggsyggtyrf kkefndpsna glqngfkfle pihkefpwis sgdlfslggv 181 tavqemqgpk ipwrcgrvdt pedttpdngr lpdadkdady vrtffqrlnm ndrevvalmg 241 ahalgkthlk nsgyegpwga annvftnefy lnllnedwkl ekndanneqw dsksgymmlp 301 tdysliqdpk ylsivkeyan dqdkffkdfs kafeklleng itfpkdapsp fifktleeqg 361 l // LOCUS NP_012993 743 aa linear PLN 30-JUN-2025 DEFINITION bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012993 VERSION NP_012993.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179857.3 REFERENCE 1 (residues 1 to 743) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 743) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 743) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 743) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 743) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09218. On Jul 30, 2012 this sequence version replaced NP_012993.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..743 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..743 /product="bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2" /EC_number="2.3.1.15" /EC_number="2.3.1.42" /calculated_mol_wt="83514" Region 45..348 /region_name="LPLAT" /note="Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; cl17185" /db_xref="CDD:473073" Site order(80,83,86,113..116,261..263) /site_type="active" /note="putative acyl-acceptor binding pocket [active]" /db_xref="CDD:153244" CDS 1..743 /gene="GPT2" /locus_tag="YKR067W" /gene_synonym="GAT1" /coded_by="NM_001179857.3:1..2232" /experiment="EXISTENCE:direct assay:GO:0004366 glycerol-3-phosphate O-acyltransferase activity [PMID:11544256]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:19525420|PMID:22267742|PMID:11914276|PMID:9401016|PM ID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:22267742|PMID:9401016]" /experiment="EXISTENCE:direct assay:GO:0008654 phospholipid biosynthetic process [PMID:11544256]" /experiment="EXISTENCE:direct assay:GO:0016287 glycerone-phosphate O-acyltransferase activity [PMID:11544256]" /experiment="EXISTENCE:mutant phenotype:GO:0004366 glycerol-3-phosphate O-acyltransferase activity [PMID:11544256]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:11544256]" /experiment="EXISTENCE:mutant phenotype:GO:0090207 regulation of triglyceride metabolic process [PMID:31421179]" /note="Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen" /db_xref="GeneID:853941" /db_xref="SGD:S000001775" ORIGIN 1 msapaadhna akpiphvpqa srryknsyng fvynihtwly dvsvflfnil ftiffreikv 61 rgaynvpevg vptilvcaph anqfidpalv msqtrllkts agksrsrmpc fvtaessfkk 121 rfisffgham ggipvpriqd nlkpvdenle iyapdlknhp eiikgrsknp qttpvnftkr 181 fsaksllglp dylsnaqike ipddetiils spfrtskskv velltngtnf kyaekidnte 241 tfqsvfdhlh tkgcvgifpe ggshdrpsll pikagvaima lgavaadptm kvavvpcglh 301 yfhrnkfrsr avleygepiv vdgkygemyk dspretvskl lkkitnslfs vtenapdydt 361 lmviqaarrl yqpvkvrlpl paiveinrrl lfgyskfkdd priihlkklv ydynrkldsv 421 glkdhqvmql kttklealrc fvtlivrlik fsvfailslp gsilftpifi icrvysekka 481 keglkkslvk ikgtdllatw klivalilap ilyvtysill iilarkqhyc riwvpsnnaf 541 iqfvyfyall vfttysslkt geigvdlfks lrplfvsivy pgkkieeiqt trknlslelt 601 avcndlgplv fpdydklate ifskrdgydv ssdaessisr msvqsrsrss sihsigslas 661 nalsrvnsrg sltdipifsd akqgqwkseg etsededefd eknpaivqta rssdlnkens 721 rntnisskia slvrqkrehe kke // LOCUS NP_012994 193 aa linear PLN 30-JUN-2025 DEFINITION TRAPP complex core subunit BET3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012994 VERSION NP_012994.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179858.1 REFERENCE 1 (residues 1 to 193) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 193) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 193) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 193) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09219. Method: conceptual translation. FEATURES Location/Qualifiers source 1..193 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..193 /product="TRAPP complex core subunit BET3" /calculated_mol_wt="21998" Region 26..182 /region_name="TRAPPC3_bet3" /note="Bet3-TRAPPC3 subunit of the TRAPP complex; cd14942" /db_xref="CDD:271345" Site order(26..30,32..34,36..37,40,55,59,62..63,66..67,70, 97..98,100,121,143) /site_type="other" /note="TRS31 interface [polypeptide binding]" /db_xref="CDD:271345" Site order(30,67..68,71,77..81,85..86,89..90,94..95,98..99, 143..144,147..148,151..152,157) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:271345" Site order(65..66,69..70,72..75,77,79,154) /site_type="other" /note="TRS23 interface [polypeptide binding]" /db_xref="CDD:271345" CDS 1..193 /gene="BET3" /locus_tag="YKR068C" /coded_by="NM_001179858.1:1..582" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17110339]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0033106 cis-Golgi network membrane [PMID:9564032]" /experiment="EXISTENCE:direct assay:GO:1990070 TRAPPI protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990072 TRAPPIII protein complex [PMID:20375281]" /experiment="EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17041589|PMID:8590804|PMID:11102533]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8590804]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:25581738]" /experiment="EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:25581738]" /experiment="EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17287728]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11239471|PMID:8590804]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11239471]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:25581738]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:25581738]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:25581738]" /note="Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); hydrophilic homodimeric protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles" /db_xref="GeneID:853942" /db_xref="SGD:S000001776" ORIGIN 1 mvsttqsrsl kamgeeiwkn ktekintelf tltygsivaq lcqdyerdfn kvndhlysmg 61 ynigcrlied flartalprc enlvktsevl skcafkifln itpnitnwsh nkdtfslild 121 enpladfvel pmdamkslwy snilcgvlkg slemvqldcd vwfvsdilrg dsqteikvkl 181 nrilkdeipi ged // LOCUS NP_012995 593 aa linear PLN 30-JUN-2025 DEFINITION uroporphyrinogen-III C-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_012995 VERSION NP_012995.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179859.3 REFERENCE 1 (residues 1 to 593) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 593) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 593) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 593) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09220. On Jul 30, 2012 this sequence version replaced NP_012995.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..593 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..593 /product="uroporphyrinogen-III C-methyltransferase" /EC_number="2.1.1.107" /calculated_mol_wt="65994" Region 26..209 /region_name="CysG2" /note="Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme transport and metabolism]; COG1648" /db_xref="CDD:441254" Region 331..556 /region_name="SUMT" /note="Uroporphyrin-III C-methyltransferase (also known as S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); cd11642" /db_xref="CDD:381169" Site order(335,358..360,411..413,416..419,441..442,446,467, 469..471,489..494,517,519..520,522,546..549) /site_type="active" /db_xref="CDD:381169" Site order(335,360,411..413,416..418,441..442,446,489..491,517, 519..520,522,547..549) /site_type="other" /note="SAM binding site [chemical binding]" /db_xref="CDD:381169" Site order(339..344,346..347,350..351,372,374,413,415..416, 421..422,424..425,428,435,436,438..441,444,448,453..457, 461..467,485,523) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:381169" Site order(358..360,417..419,467,469..471,491..494,546) /site_type="other" /note="chemical substrate binding site [chemical binding]" /db_xref="CDD:381169" CDS 1..593 /gene="MET1" /locus_tag="YKR069W" /gene_synonym="MET20" /coded_by="NM_001179859.3:1..1782" /experiment="EXISTENCE:direct assay:GO:0004851 uroporphyrin-III C-methyltransferase activity [PMID:10051442]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0019354 siroheme biosynthetic process [PMID:9003798]" /note="S-adenosyl-L-methionine uroporphyrinogen III transmethylase; involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis" /db_xref="GeneID:853943" /db_xref="SGD:S000001777" ORIGIN 1 mvrdlvtlps slplitagfa tdqvhlligt gstdsvsvck nrihsilnag gnpivvnpss 61 pshtkqlqle fgkfakfeiv erefrlsdlt tlgrvlvckv vdrvfvdlpi tqsrlceeif 121 wqcqklripi ntfhkpefst fnmiptwvdp kgsglqisvt tngngyilan rikrdiishl 181 ppnisevvin mgylkdriin edhkalleek yyqtdmslpg fgygldedgw eshkfnklir 241 efemtsreqr lkrtrwlsqi meyypmnkls dikledfets sspnkktkqe tvtegvvppt 301 deniengtkq lqlsevkkee gpkklgkisl vgsgpgsvsm ltigalqeik sadiiladkl 361 vpqaildlip pktetfiakk fpgnaeraqq ellakglesl dnglkvvrlk qgdpyifgrg 421 geefnffkdh gyipvvlpgi ssslactvla qipatqrdia dqvlictgtg rkgalpiipe 481 fvesrttvfl malhranvli tgllkhgwdg dvpaaiverg scpdqrvtrt llkwvpevve 541 eigsrppgvl vvgkavnalv ekdlinfdes rkfvidegfr efevdvdslf kly // LOCUS NP_012996 352 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKR070W [Saccharomyces cerevisiae S288C]. ACCESSION NP_012996 VERSION NP_012996.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179860.1 REFERENCE 1 (residues 1 to 352) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 352) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 352) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 352) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09221. Method: conceptual translation. FEATURES Location/Qualifiers source 1..352 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..352 /product="uncharacterized protein" /calculated_mol_wt="39275" Region 14..348 /region_name="CECR5" /note="HAD-superfamily class IIA hydrolase, TIGR01456, CECR5" /db_xref="CDD:200106" CDS 1..352 /locus_tag="YKR070W" /coded_by="NM_001179860.1:1..1059" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14562095|PMID:16823961]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:853944" /db_xref="SGD:S000001778" ORIGIN 1 migkrffqtt skkiafafdi dgvlfrgkkp iagasdalkl lnrnkipyil ltngggfser 61 artefisskl dvdvsplqii qshtpykslv nkysrilavg tpsvrgvaeg ygfqdvvhqt 121 divrynrdia pfsglsdeqv meysrdipdl ttkkfdavlv fndphdwaad iqiisdains 181 engmlntlrn eksgkpsipi yfsnqdllwa npyklnrfgq gafrllvrrl ylelngeplq 241 dytlgkptkl tydfahhvli dwekrlsgki gqsvkqklpl lgtkpstspf havfmvgdnp 301 asdiigaqny gwnsclvktg vynegddlke ckptlivndv fdavtktlek ya // LOCUS NP_012997 348 aa linear PLN 30-JUN-2025 DEFINITION electron carrier DRE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012997 VERSION NP_012997.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179861.3 REFERENCE 1 (residues 1 to 348) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 348) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 348) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 348) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09222. On Jul 30, 2012 this sequence version replaced NP_012997.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..348 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..348 /product="electron carrier DRE2" /calculated_mol_wt="38412" Region 56..348 /region_name="COG5636" /note="Uncharacterized conserved protein, contains Zn-ribbon-like motif [Function unknown]" /db_xref="CDD:227923" CDS 1..348 /gene="DRE2" /locus_tag="YKR071C" /coded_by="NM_001179861.3:1..1047" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:18625724]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18625724]" /experiment="EXISTENCE:direct assay:GO:0051537 2 iron, 2 sulfur cluster binding [PMID:27166425]" /experiment="EXISTENCE:direct assay:GO:0051539 4 iron, 4 sulfur cluster binding [PMID:27166425]" /experiment="EXISTENCE:mutant phenotype:GO:0009055 electron transfer activity [PMID:20802492]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:20802492|PMID:18625724]" /experiment="EXISTENCE:mutant phenotype:GO:0045019 negative regulation of nitric oxide biosynthetic process [PMID:27178802]" /experiment="EXISTENCE:mutant phenotype:GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death [PMID:27178802]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27178802]" /note="Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p in an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress; inviability of the null mutant is functionally complemented by human CIAPIN1" /db_xref="GeneID:853945" /db_xref="SGD:S000001779" ORIGIN 1 msqyktglll ihpavtttpe lventkaqaa skkvkfvdqf linklndgsi tlenakyetv 61 hyltpeaqtd ikfpkklisv ladslkpngs liglsdiykv dalingfeii nepdycwikm 121 dssklnqtvs iplkkkktnn tklqsgsklp tfkkasssts nlpsfkkadh srqpivketd 181 sfkppsfkmt tepkvyrvvd dliedsdddd fssdsskaqy fdqvdtsdds ieeeelided 241 gsgksmitmi tcgksktkkk kackdctcgm keqeeneind irsqqdkvvk ftedelteid 301 ftidgkkvgg cgscslgdaf rcsgcpylgl pafkpgqpin ldsisddl // LOCUS NP_012998 562 aa linear PLN 30-JUN-2025 DEFINITION phosphopantothenoylcysteine decarboxylase complex subunit SIS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_012998 VERSION NP_012998.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179862.1 REFERENCE 1 (residues 1 to 562) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 562) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 562) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 562) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09223. Method: conceptual translation. FEATURES Location/Qualifiers source 1..562 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..562 /product="phosphopantothenoylcysteine decarboxylase complex subunit SIS2" /calculated_mol_wt="62347" Region 205..>489 /region_name="PRK13982" /note="bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional" /db_xref="CDD:172484" Region <353..474 /region_name="Flavoprotein" /note="cl19190" /db_xref="CDD:450266" CDS 1..562 /gene="SIS2" /locus_tag="YKR072C" /gene_synonym="HAL3" /coded_by="NM_001179862.1:1..1689" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:7705654]" /experiment="EXISTENCE:direct assay:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]" /experiment="EXISTENCE:direct assay:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:9636153]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7705654]" /experiment="EXISTENCE:direct assay:GO:0071513 phosphopantothenoylcysteine decarboxylase complex [PMID:19915539]" /experiment="EXISTENCE:direct assay:GO:1990143 CoA-synthesizing protein complex [PMID:23789928]" /experiment="EXISTENCE:genetic interaction:GO:0007346 regulation of mitotic cell cycle [PMID:10022927]" /experiment="EXISTENCE:genetic interaction:GO:0015937 coenzyme A biosynthetic process [PMID:19915539]" /experiment="EXISTENCE:mutant phenotype:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:9636153]" /note="Negative regulatory subunit of protein phosphatase 1 (Ppz1p); involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC: Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p); dose-dependent regulator of replicative lifespan; SIS2 has a paralog, VHS3, that arose from the whole genome duplication" /db_xref="GeneID:853946" /db_xref="SGD:S000001780" ORIGIN 1 mtavastsgk qdadhnqsie cprfsrgqke illdhedakg kdsiinspvs grqsisptls 61 natttttksi mnatgtsgav vsntpepglk rvpavtfsdl kqqqkqdslt qlkndsertk 121 spnsnpapvs nsipgnhavi pnhtntsrtt qlsgsplvne mkdydpkkkd salkivdtmk 181 pdkimatstp isrennkvta kaptsitlrk edaqdqannv sgqinvrstp eetpvkqsvi 241 psiipkrens knldprlpqd dgklhvlfga tgslsvfkik pmikkleeiy grdrisiqvi 301 ltqsatqffe qrytkkiiks seklnkmsqy estpatpvtp tpgqcnmaqv velpphiqlw 361 tdqdewdawk qrtdpvlhie lrrwadilvv apltantlsk ialglcdnll tsvirawnps 421 ypillapsmv sstfnsmmtk kqlqtikeem swvtvfkpse kvmdingdig lggmmdwnei 481 vnkivmklgg ypknneeedd dedeeeddde eedtedknen nndddddddd dddddddddd 541 ddddddeded eaetpgiidk hq // LOCUS NP_001335792 106 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKR073C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335792 VERSION NP_001335792.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348852.1 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 106) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80312. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..106 /product="uncharacterized protein" /calculated_mol_wt="11843" CDS 1..106 /locus_tag="YKR073C" /coded_by="NM_001348852.1:1..321" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:853947" /db_xref="SGD:S000001781" ORIGIN 1 mivfdvslmi iiifsfafnm sqsnilmlyn sphvlvgsda rnffsckkwh rcfsgevile 61 ekksqsalgs rsltctcpli savqlhlers ffslaffavi llyipg // LOCUS NP_013000 155 aa linear PLN 30-JUN-2025 DEFINITION Aim29p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013000 VERSION NP_013000.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179864.3 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 155) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09224. On Jul 30, 2012 this sequence version replaced NP_013000.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..155 /product="Aim29p" /calculated_mol_wt="18305" Region 34..155 /region_name="DUF2340" /note="Uncharacterized conserved protein (DUF2340); pfam10209" /db_xref="CDD:462998" CDS 1..155 /gene="AIM29" /locus_tag="YKR074W" /coded_by="NM_001179864.3:1..468" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /note="Zpr1p co-chaperone; recognizes eEF1A in GTP-bound, pre-hydrolysis conformation, dampens folding complex GTPase activity to drive client release from Zpr1p" /db_xref="GeneID:853949" /db_xref="SGD:S000001782" ORIGIN 1 mnstkrlkms ttfhdydlee pltsnarplk nsvitirvik sfpyrnvkni vlhdydladk 61 takdlfndvl nkiqnegsfr pfrnvkfdtl kiythahgsk tvnlvinfdh dddwtldien 121 dkkklfeygi eneteislfn kedylrfken peekw // LOCUS NP_013001 307 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKR075C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013001 VERSION NP_013001.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179865.1 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 307) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09225. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..307 /product="uncharacterized protein" /calculated_mol_wt="35982" CDS 1..307 /locus_tag="YKR075C" /coded_by="NM_001179865.1:1..924" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /note="hypothetical protein; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YKR075C has a paralog, YOR062C, that arose from the whole genome duplication" /db_xref="GeneID:853950" /db_xref="SGD:S000001783" ORIGIN 1 mtslddtiis yqnimlldnm tnynkpaidy fhhefndasl eisaswtlll kmrkhkllrl 61 pscssedvld ynmylvrlhh clwrrwsinh yglqnsksnp lsinwnketd vtvlygpdlt 121 nidsneneis pvqnqidqkq tknlksalkk ntecwvteev deinasiesn dnalvkledi 181 scpssvdsht ssifdqhstc tkissideds edlmnekkeq fprklkfnqa vmkreidskg 241 tireslinin diqhsrhhrr hhrrhhhhhh qnsshsdeti keahyefsny tfgtmeedif 301 yrnqvvf // LOCUS NP_013002 370 aa linear PLN 30-JUN-2025 DEFINITION S-glutathionyl-(chloro)hydroquinone reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013002 VERSION NP_013002.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179866.3 REFERENCE 1 (residues 1 to 370) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 370) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 370) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 370) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09226. On Jul 30, 2012 this sequence version replaced NP_013002.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..370 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..370 /product="S-glutathionyl-(chloro)hydroquinone reductase" /EC_number="1.8.5.1" /EC_number="2.5.1.18" /calculated_mol_wt="43143" Region 4..366 /region_name="ECM4" /note="Glutathionyl-hydroquinone reductase [Energy production and conversion]; COG0435" /db_xref="CDD:440204" CDS 1..370 /gene="ECM4" /locus_tag="YKR076W" /gene_synonym="GTO2" /coded_by="NM_001179866.3:1..1113" /experiment="EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:20388120|PMID:16709151|PMID:22686328]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16936141|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006749 glutathione metabolic process [PMID:22686328|PMID:20388120]" /note="S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm" /db_xref="GeneID:853951" /db_xref="SGD:S000001784" ORIGIN 1 mskqwasgtn gafkrqvssf retiskqhpi ykpakgrywl yvslacpwah rtlitralkg 61 ltsvigcsvv hwhldekgwr fldmekqled sedflehwhd vaggirtake dssksfaeik 121 ndsqrfmvda tnephygykr isdlyyksdp qysarftvpv lwdletqtiv nnesseiiri 181 lnssafdefv dddhkktdlv paqlktqidd fnswvydsin ngvyktgfae kaevyesevn 241 nvfehldkve kilsdkyskl kakygeedrq kilgefftvg dqlteadirl yttvirfdpv 301 yvqhfkcnft siragypfih lwvrnlywny dafryttdfd hiklhytrsh trinplgitp 361 lgpkpdirpl // LOCUS NP_013003 363 aa linear PLN 30-JUN-2025 DEFINITION Msa2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013003 VERSION NP_013003.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179867.1 REFERENCE 1 (residues 1 to 363) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 363) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 363) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 363) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09227. Method: conceptual translation. FEATURES Location/Qualifiers source 1..363 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..363 /product="Msa2p" /calculated_mol_wt="39731" CDS 1..363 /gene="MSA2" /locus_tag="YKR077W" /coded_by="NM_001179867.1:1..1092" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:physical interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:18160399]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:18160399]" /note="Putative transcriptional activator; interacts with G1-specific transcription factor MBF and G1-specific promoters; MSA2 has a paralog, MSA1, that arose from the whole genome duplication" /db_xref="GeneID:853952" /db_xref="SGD:S000001785" ORIGIN 1 mvyttpqqqq rfsstpqssh tlifspirap smqtpssldy qspsivvsss smkvhgrsss 61 fgkfslsigq ngkatilgpi nvlptdtskm ekpvpkkkpv tsdrvektri lsllkkmrnk 121 sstvnkkysk vplksttslq paatapsplv sniikpspkk lasprtpnan snlnlnftsf 181 qiktgftpnl dgillenfts pnttadsqgn sasniinnnh gsanntnqfl fnlplqsspr 241 qfrsparlid plpisdwnts llmspprttn fesannhfns nfaqasmlrr pslphidevi 301 pqdsnpanys drsdylsvdq nannhngals eqtynnimks smislpiekd datmalrklv 361 sre // LOCUS NP_013004 585 aa linear PLN 30-JUN-2025 DEFINITION sorting nexin family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013004 VERSION NP_013004.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179868.3 REFERENCE 1 (residues 1 to 585) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 585) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 585) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 585) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09228. On Jul 30, 2012 this sequence version replaced NP_013004.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..585 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..585 /product="sorting nexin family protein" /calculated_mol_wt="68151" Region 136..243 /region_name="PX_domain" /note="The Phox Homology domain, a phosphoinositide binding module; cl02563" /db_xref="CDD:470617" Site order(152..154,184..185) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:132771" Region 361..580 /region_name="BAR_SNX" /note="The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins; cd07596" /db_xref="CDD:153280" Site order(372,375..376,380..381,383..384,387,390..391,394, 401..402,404..405,408,411..412,415..416,432,542,545..546, 548..550,553,556..557,559..561,563..564,567..568,570..571, 574..575,577..578) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153280" CDS 1..585 /gene="VPS501" /locus_tag="YKR078W" /gene_synonym="VIN1" /coded_by="NM_001179868.3:1..1758" /experiment="EXISTENCE:direct assay:GO:0001786 phosphatidylserine binding [PMID:35098628]" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:35098628]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:35098628]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:35098628|PMID:11557775]" /experiment="EXISTENCE:mutant phenotype:GO:1903432 regulation of TORC1 signaling [PMID:35098628]" /note="Vacuolar SNX-BAR protein, regulates TORC1 signaling during autophagy induction; binds phosphatidylinositol-3-phosphate; vacuolar localization of Vps501p is dependent upon direct interaction with Iml1p and a unique lipid binding specificity that is also required for its function; VPS501 has paralog VPS5 that arose from the whole genome duplication" /db_xref="GeneID:853953" /db_xref="SGD:S000001786" ORIGIN 1 mendkashas psigvnefvv qgeisiddse rsvksvsvsi sddedsktdv qdnmatpstr 61 skfqtdlaid nrllekdpky kklftekrrr rrpescinlm tkgkgtgqkd nindqifslr 121 ilpgsdlnsl kdslwiikis tqpdvektia rafsdfywly hqlqnnhwgk tippptrsni 181 lvekdefain hlfmirnnek ydpifnfkpe yiislqlmam ikhifndkvl rldsnfidfi 241 swdddlpesl qivvddstft gdkilmtssq frelkefhkq skkvesitns haslipvtel 301 teiyisptkl fsrkdyqrlf qpqstdntfn nndpliqewi pksktlftsl sfgssaptyq 361 easteiqach dwvsiskeqw kqllyhvlqy ivdeavkvns vinefteclk qisldevira 421 nselflkfsk lnesflkkfk gasrqdilkl iilfdenvrf cesfesilnq rlklgkilsi 481 ievdldkkkn fldklspgnn nsnnedlkir taedeyrivl krynrvkqsw ekimedilne 541 rkefekreaa evnsclksir dlnmdekkhy lqlwqdfvpd ehisq // LOCUS NP_013005 838 aa linear PLN 30-JUN-2025 DEFINITION tRNase Z [Saccharomyces cerevisiae S288C]. ACCESSION NP_013005 VERSION NP_013005.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179869.1 REFERENCE 1 (residues 1 to 838) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 838) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 838) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 838) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 838) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 838) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 838) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09229. Method: conceptual translation. FEATURES Location/Qualifiers source 1..838 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..838 /product="tRNase Z" /EC_number="3.1.26.11" /calculated_mol_wt="96685" Region 6..68 /region_name="Lactamase_B_4" /note="tRNase Z endonuclease; pfam13691" /db_xref="CDD:404562" Region 35..>132 /region_name="ElaC" /note="Ribonuclease BN, tRNA processing enzyme [Translation, ribosomal structure and biogenesis]; COG1234" /db_xref="CDD:440847" Region <145..250 /region_name="tRNA_deacylase" /note="D-aminoacyl-tRNA deacylase; cl00716" /db_xref="CDD:469887" Region 468..723 /region_name="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold" /note="Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain; cd07718" /db_xref="CDD:293804" Site order(508,539..540,542,544..545,670..671,699,721) /site_type="active" /note="putative active site [active]" /db_xref="CDD:293804" CDS 1..838 /gene="TRZ1" /locus_tag="YKR079C" /coded_by="NM_001179869.1:1..2517" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:24249226]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14690591|PMID:24249226]" /experiment="EXISTENCE:direct assay:GO:0042780 tRNA 3'-end processing [PMID:12711671|PMID:24249226]" /experiment="EXISTENCE:direct assay:GO:0042781 3'-tRNA processing endoribonuclease activity [PMID:24249226|PMID:12711671]" /experiment="EXISTENCE:direct assay:GO:1990180 mitochondrial tRNA 3'-end processing [PMID:24249226]" /experiment="EXISTENCE:mutant phenotype:GO:0042780 tRNA 3'-end processing [PMID:24249226]" /experiment="EXISTENCE:mutant phenotype:GO:1990180 mitochondrial tRNA 3'-end processing [PMID:24249226]" /note="tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2" /db_xref="GeneID:853954" /db_xref="SGD:S000001787" ORIGIN 1 mftfipithp tsdtkhplll vqsahgekyf fgkigegsqr sltenkiris klkdifltge 61 lnwsdigglp gmiltiadqg ksnlvlhygn dilnyivstw ryfvfrfgid lndhimkdke 121 vykdkiiavk sfnvlkngge drlgvfdsfq kgvlrsivak mfpkhaptdr ydpssdphln 181 velpdldakv evstnyeisf spvrgkfkve eaiklgvpkg plfakltkgq titldngivv 241 tpeqvlener hfakvlildi pddlylnafv ekfkdydcae lgmvyyflgd evtindnlfa 301 fidifeknny gkvnhmishn kispntisff gsalttlklk alqvnnynlp ktdrvfskdf 361 ydrfdtplsr gtsmcksqee plntiiekdn ihifsqnktv tfepfrmnee pmkcningev 421 adfswqeife ehvkplefpl advdtvinnq lhvdnfnnsa ekkkhveiit lgtgsalpsk 481 yrnvvstlvk vpftdadgnt inrnimldag entlgtihrm fsqlavksif qdlkmiylsh 541 lhadhhlgii svlnewykyn kddetsyiyv vtpwqyhkfv newlvlenke ilkrikyisc 601 ehfindsfvr mqtqsvplae fneilkensn qesnrkleld rdssyrdvdl irqmyedlsi 661 eyfqtcraih cdwaysnsit frmdennehn tfkvsysgdt rpniekfsle igynsdllih 721 eatlenqlle davkkkhcti neaigvsnkm narklilthf sqrypklpql dnnidvmare 781 fcfafdsmiv dyekigeqqr ifpllnkafv eekeeeedvd dvesvqdlev klkkhkkn // LOCUS NP_013006 320 aa linear PLN 30-JUN-2025 DEFINITION methylenetetrahydrofolate dehydrogenase (NAD(+)) [Saccharomyces cerevisiae S288C]. ACCESSION NP_013006 VERSION NP_013006.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179870.3 REFERENCE 1 (residues 1 to 320) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 320) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 320) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 320) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09230. On Jul 30, 2012 this sequence version replaced NP_013006.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..320 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..320 /product="methylenetetrahydrofolate dehydrogenase (NAD(+))" /EC_number="1.5.1.15" /calculated_mol_wt="36109" Region 8..121 /region_name="THF_DHG_CYH" /note="Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; pfam00763" /db_xref="CDD:459930" Region 116..316 /region_name="NAD_bind_m-THF_DH" /note="NAD binding domain of methylene-tetrahydrofolate dehydrogenase; cd01079" /db_xref="CDD:133447" Site order(184..186,208..209,252..254,274,276,295) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:133447" Site order(211..216,226..230) /site_type="other" /note="putative homodimer interface [polypeptide binding]" /db_xref="CDD:133447" CDS 1..320 /gene="MTD1" /locus_tag="YKR080W" /coded_by="NM_001179870.3:1..963" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:8608153]" /experiment="EXISTENCE:direct assay:GO:0006730 one-carbon metabolic process [PMID:8608153]" /experiment="EXISTENCE:direct assay:GO:0009113 purine nucleobase biosynthetic process [PMID:8608153]" /experiment="EXISTENCE:mutant phenotype:GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity [PMID:8416923]" /experiment="EXISTENCE:mutant phenotype:GO:0006730 one-carbon metabolic process [PMID:8608153]" /experiment="EXISTENCE:mutant phenotype:GO:0009113 purine nucleobase biosynthetic process [PMID:8608153]" /experiment="EXISTENCE:mutant phenotype:GO:0009396 folic acid-containing compound biosynthetic process [PMID:8608153]" /note="NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase; plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline" /db_xref="GeneID:853955" /db_xref="SGD:S000001788" ORIGIN 1 mskpgrtila skvaetfnte iinnveeykk thngqgpllv gflanndpaa kmyatwtqkt 61 sesmgfrydl rviedkdfle eaiiqangdd svngimvyfp vfgnaqdqyl qqvvckekdv 121 eglnhvyyqn lyhnvryldk enrlksilpc tplaivkile flkiynnllp egnrlygkkc 181 ivinrseivg rplaalland gatvysvdvn niqkftrges lklnkhhved lgeysedllk 241 kcsldsdvvi tgvpsenykf pteyikegav cinfactknf sddvkekasl yvpmtgkvti 301 amllrnmlrl vrnvelskek // LOCUS NP_013007 344 aa linear PLN 30-JUN-2025 DEFINITION rRNA-binding ribosome biosynthesis protein RPF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013007 VERSION NP_013007.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179871.1 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 344) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09231. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..344 /product="rRNA-binding ribosome biosynthesis protein RPF2" /calculated_mol_wt="39468" Region 1..324 /region_name="RPF2" /note="Uncharacterized conserved protein [Function unknown]; COG5106" /db_xref="CDD:227437" CDS 1..344 /gene="RPF2" /locus_tag="YKR081C" /coded_by="NM_001179871.1:1..1035" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11864606]" /experiment="EXISTENCE:direct assay:GO:0008097 5S rRNA binding [PMID:11864606|PMID:25855814]" /experiment="EXISTENCE:direct assay:GO:0008312 7S RNA binding [PMID:11864606]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:11864606]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:11864606]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11864606]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11864606]" /experiment="EXISTENCE:mutant phenotype:GO:0008097 5S rRNA binding [PMID:25855814]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]" /note="Essential protein involved in rRNA maturation and ribosomal assembly; involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles" /db_xref="GeneID:853956" /db_xref="SGD:S000001789" ORIGIN 1 mirtvkpkna rakralvkre aklvenvkqa lfipgqscnk nlhdimvdls alkkpdmkrf 61 nrkndihpfe dmspleffse kndcslmvlm tsskkrknnm tfirtfgyki ydmielmvad 121 nfkllsdfkk ltftvglkpm ftfqgaafdt hpvykqiksl fldffrgest dlqdvaglqh 181 vismtiqgdf qdgeplpnvl frvyklksyk sdqggkrlpr ielveigprl dfkigrihtp 241 spdmvteahk kpkqlemktk knveldimgd klgrihmgkq dlgklqtrkm kglkskfdqg 301 teegdgevde dyedeasysd dgqeyeeefv satdiepsak rqkk // LOCUS NP_013008 1157 aa linear PLN 30-JUN-2025 DEFINITION Nup133p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013008 VERSION NP_013008.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179872.3 REFERENCE 1 (residues 1 to 1157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1157) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09232. On Jul 30, 2012 this sequence version replaced NP_013008.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1157 /product="Nup133p" /calculated_mol_wt="133190" Region 62..475 /region_name="Nucleoporin_N" /note="Nup133 N terminal like; pfam08801" /db_xref="CDD:400932" Region <759..1049 /region_name="Nucleoporin_C" /note="Non-repetitive/WGA-negative nucleoporin C-terminal; pfam03177" /db_xref="CDD:427181" CDS 1..1157 /gene="NUP133" /locus_tag="YKR082W" /gene_synonym="RAT3" /coded_by="NM_001179872.3:1..3474" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:21818277]" /experiment="EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:18046406|PMID:11823431]" /experiment="EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:15725626]" /experiment="EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:22110603]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16418532|PMID:17538013]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:8524308]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:7813444|PMID:21036941]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:22331846]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16418532]" /experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16418532]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:12730220]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22110603]" /experiment="EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:7862658|PMID:22331846|PMID:9725905|PMID:7813444]" /note="Subunit of Nup84p subcomplex of nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis; is involved in establishment of a normal nucleocytoplasmic concentration gradient of GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at nuclear periphery, including double-strand break repair, transcription and chromatin silencing; relocalizes to cytosol in response to hypoxia; homolog of human NUP133" /db_xref="GeneID:853957" /db_xref="SGD:S000001790" ORIGIN 1 msekkvhlrl rkelsvpiav veneslaqls yeeesqaslm dismeqqqlr lhshfdnskv 61 ftennryivk tlqtdyssgf snddelngyi dmqigyglvn dhkkvyiwni hstqkdtpyi 121 tvpfrsddnd eiavaprcil tfpatmdesp lalnpndqde tggliiikgs kaiyyedins 181 innlnfklse kfshelelpi nssggekcdl mlncepagiv lstnmgriff itirnsmgkp 241 qlklgkllnk pfklgiwski fntnssvvsl rngpilgkgt rlvyittnkg ifqtwqlsat 301 nshptklidv niyeailesl qdlypfahgt lkiwdshplq dessqlflss iydsscnety 361 yilstiifds ssnsftifst yrlntfmesi tdtkfkpkif ipqmenandt nevtsilvmf 421 pnavvitqvn skldssysmr rkwedivslr ndidiigsgy dskslyvltk qmgvlqffvk 481 eneetnskpe vgfvkshvdq avyfskinan pidfnlppei sldqesiehd lkltseeifh 541 sngkyippml ntlgqhlsvr keffqnfltf vaknfnykis pelkldliek feilnccikf 601 nsiirqsdvl ndiwektlsn ynltqnehlt tktvvinspd vfpvifkqfl nhvvfvlfps 661 qnqnfklnvt nlinlcfydg ileegektir yelleldpme vdtsklpwfi nfdylncinq 721 cffdftface eegsldsyke gllkivkily yqfnqfkiwi ntqpvksvna ndnfininnl 781 yddnhldwnh vlckvnlkeq ciqiaefykd lsglvqtlqt ldqndsttvs lyetffnefp 841 kefsftlfey likhkklndl ifrfpqqhdv liqffqesap kyghvawiqq ildgsyadam 901 ntlknitvdd skkgeslsec elhlnvakls sllvekdnld intlrkiqyn ldtidaekni 961 snklkkgevq ickrfkngsi revfnilvee lksttvvnls dlvelysmld deeslfiplr 1021 llsvdgnlln fevkkflnal vwrrivllna snegdkllqh ivkrvfdeel pknndfplps 1081 vdllcdksll tpeyisetyg rfpidqnair eeiyeeisqv etlnsdnsle iklhstigsv 1141 akeknytiny etntvey // LOCUS NP_013009 133 aa linear PLN 30-JUN-2025 DEFINITION Dad2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013009 VERSION NP_013009.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179873.1 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 133) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09233. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..133 /product="Dad2p" /calculated_mol_wt="14940" Region 6..129 /region_name="DASH_Dad2" /note="DASH complex subunit Dad2; pfam08654" /db_xref="CDD:430134" CDS 1..133 /gene="DAD2" /locus_tag="YKR083C" /gene_synonym="HSK1" /coded_by="NM_001179873.1:1..402" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:15664196|PMID:16777964]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0031116 positive regulation of microtubule polymerization [PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0042729 DASH complex [PMID:15640796|PMID:15664196]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:20479465|PMID:17620411]" /experiment="EXISTENCE:direct assay:GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore [PMID:20479468|PMID:20479465]" /note="Essential subunit of the Dam1 complex (aka DASH complex); complex couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis" /db_xref="GeneID:853958" /db_xref="SGD:S000001791" ORIGIN 1 mdsideqiai krkelqslqk itsltdglki qltelneqik emgmnadsva qlmnnwdsii 61 nnisqaslgl lqyaegdyei gpwkdskkke seqsnetgle aqendknded ndededlvpl 121 petmvrirvd gne // LOCUS NP_013010 611 aa linear PLN 30-JUN-2025 DEFINITION ribosome dissociation factor GTPase HBS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013010 VERSION NP_013010.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179874.3 REFERENCE 1 (residues 1 to 611) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 611) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 611) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 611) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09234. On Jul 30, 2012 this sequence version replaced NP_013010.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..611 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..611 /product="ribosome dissociation factor GTPase HBS1" /calculated_mol_wt="68599" Region 5..73 /region_name="HBS1_N" /note="HBS1 N-terminus; pfam08938" /db_xref="CDD:462642" Region 166..611 /region_name="TEF1" /note="Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]; COG5256" /db_xref="CDD:444074" Region 169..383 /region_name="EF1_alpha" /note="Elongation Factor 1-alpha (EF1-alpha) protein family; cd01883" /db_xref="CDD:206670" Site 174..181 /site_type="other" /note="G1 box" /db_xref="CDD:206670" Site order(175,177,181..182,185,188..189,236..237,255..256, 279..280,327,331) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206670" Site order(177,179..182,313..314,316,352..354) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206670" Site order(181,224,227..228,230,232,234..236,238,249,251, 253..255,257,260) /site_type="other" /note="EF1Balpha binding site [polypeptide binding]" /db_xref="CDD:206670" Site 226..236 /site_type="other" /note="Switch I region" /db_xref="CDD:206670" Site 232 /site_type="other" /note="G2 box" /db_xref="CDD:206670" Site 251..254 /site_type="other" /note="G3 box" /db_xref="CDD:206670" Site 253..271 /site_type="other" /note="Switch II region" /db_xref="CDD:206670" Site 313..316 /site_type="other" /note="G4 box" /db_xref="CDD:206670" Site 352..354 /site_type="other" /note="G5 box" /db_xref="CDD:206670" CDS 1..611 /gene="HBS1" /locus_tag="YKR084C" /coded_by="NM_001179874.3:1..1836" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:20947765]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:20947765]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:21623367]" /experiment="EXISTENCE:direct assay:GO:1990533 Dom34-Hbs1 complex [PMID:21623367]" /experiment="EXISTENCE:genetic interaction:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:16554824]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:24424461]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]" /note="GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, particularly in 3' UTRs; genetically implicated in mRNA no-go decay; HBS1 has a paralog, SKI7, that arose from the whole genome duplication" /db_xref="GeneID:853959" /db_xref="SGD:S000001792" ORIGIN 1 maysdysdga ddmpdfhdeg efddylndde ydlmnevfpt lkaqlqdyqg wdnlslklal 61 fdnnfdlest laelkktlkk kktpkkpiaa angsanvtqk lanisisqqr pndrlpdwld 121 eeesegerng eeandektvq ryykttvptk pkkphdisaf vksalphlsf vvlghvdagk 181 stlmgrllyd lnivnqsqlr klqresetmg kssfkfawim dqtneererg vtvsictshf 241 sthranftiv dapghrdfvp naimgisqad mailcvdcst nafesgfdld gqtkehmlla 301 sslgihnlii amnkmdnvdw sqqrfeeiks kllpylvdig ffedninwvp isgfsgegvy 361 kieytdevrq wyngpnlmst lenaafkisk eneginkddp flfsvleiip skktsndlal 421 vsgklesgsi qpgesltiyp seqscivdki qvgsqqgqst nheetdvaik gdfvtlklrk 481 aypediqngd laasvdyssi hsaqcfvlel ttfdmnrpll pgtpfilfig vkeqparikr 541 lisfidkgnt askkkirhlg skqrafveie lievkrwipl ltahendrlg rvvlrkdgrt 601 iaagkiseit q // LOCUS NP_013011 195 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL58 MRPL20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013011 VERSION NP_013011.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179875.1 REFERENCE 1 (residues 1 to 195) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 195) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 195) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 195) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09235. Method: conceptual translation. FEATURES Location/Qualifiers source 1..195 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..195 /product="mitochondrial 54S ribosomal protein mL58 MRPL20" /calculated_mol_wt="22261" Region 32..192 /region_name="MRP-L20" /note="Mitochondrial ribosomal protein subunit L20; pfam12824" /db_xref="CDD:432810" CDS 1..195 /gene="MRPL20" /locus_tag="YKR085C" /gene_synonym="mL58" /coded_by="NM_001179875.1:1..588" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:853960" /db_xref="SGD:S000001793" ORIGIN 1 migrgvccrs fhtagsawkq fgfpktqvtt iynktksasn ykgylkhrda pgmyyqpses 61 iatgsvnset iprsfmaasd prrgldmpvq stkakqcpnv lvgkstvngk tyhlgpqeid 121 eirklrldnp qkytrkflaa kygisplfvs mvskpseqhv qimesrlqei qsrwkekrri 181 aredrkrrkl lwyqa // LOCUS NP_013012 1071 aa linear PLN 30-JUN-2025 DEFINITION DEAH-box RNA helicase PRP16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013012 VERSION NP_013012.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179876.3 REFERENCE 1 (residues 1 to 1071) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1071) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1071) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1071) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1071) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09236. On Jul 30, 2012 this sequence version replaced NP_013012.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1071 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1071 /product="DEAH-box RNA helicase PRP16" /EC_number="3.6.4.13" /calculated_mol_wt="121522" Region 348..>980 /region_name="HrpA" /note="HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; COG1643" /db_xref="CDD:441249" CDS 1..1071 /gene="PRP16" /locus_tag="YKR086W" /gene_synonym="PRP23; RNA16" /coded_by="NM_001179876.3:1..3216" /experiment="EXISTENCE:direct assay:GO:0000378 RNA exon ligation [PMID:23685439]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:1825134]" /experiment="EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:1825134]" /experiment="EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:16103217|PMID:1825134]" /experiment="EXISTENCE:mutant phenotype:GO:0000386 second spliceosomal transesterification activity [PMID:1825134]" /experiment="EXISTENCE:mutant phenotype:GO:0016073 snRNA metabolic process [PMID:19458033]" /experiment="EXISTENCE:mutant phenotype:GO:0040031 snRNA modification [PMID:19458033]" /note="DEAH-box RNA helicase; involved in the second catalytic step of splicing and in exon ligation; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceosome in the first catalytic step; missense mutation in human ortholog DHX38 associated with early-onset retinitis pigmentosa" /db_xref="GeneID:853961" /db_xref="SGD:S000001794" ORIGIN 1 mghsgreeri kdifkeltsk eltpgllltl qklaqkpntn leqfiascka ltklssnnpi 61 ifnellellk nkseedstgp kkiapsinkr kkfkiqldld dnedeldspv qkkpaptrtl 121 fkridklkak qlrqysptvk dpspnseqqt qnghaetkdy eptrsevvee drewydnddd 181 ygnlvpepls elpeeakllp virnidndda lrntvqlypi plkqrmewip pflskfalen 241 kvptsiiigs isetssqvsa lsmvnpfrnp dsefsanakr gsklvalrri nmehiqqsrd 301 nttvlntamg evlglennnk akdksnqkic ddtalftpsk ddikhtkeql pvfrcrsqll 361 slirenqvvv iigetgsgkt tqlaqylyee gyandrgksi vvtqprrvaa isvakrvame 421 mqvplgkevg ysirfedvtd sectklkfvt dgillretll ddtldkyscv iideahersl 481 ntdillgffk illarrrdlk liitsatmna kkfsaffgna pqftipgrtf pvqtiytsnp 541 vqdyveaavs qavkihland cssgdilifm tgqediettf dtlqekflqv yskkfgtanf 601 eeindieilp iysalpadlq fkifqdlhgt krkiiiatni aetsltikgi ryvidcgysk 661 lkvynpkigl dslvitpisk anadqrsgra grtapgtayr lytedtfked mylqtipeiq 721 rtnlsntlll lksldvtdel skfpfidkpp lqtflsslye lwfigaidts gqltplglqm 781 akfplqpsls killiavrng csdemltivs mlsvpqvfyr pkerqkeadi arnkffiaks 841 dhltllnvfe qwrannfssh wcnkhfvqyk slvrardird qlltilksqk ipvissgkdw 901 diikkcicsg fahqaakitg lrnyvhlktg vsvqlhptsa lhglgdlppy vvyhellmts 961 keyiccvtsv dpfwlmeygg llydikrikn dqeatttglf gehyehtldk veddidinir 1021 rckdmrdsvi qelkmtdnsn kedkkqktkk qnilngkens mkpfkrrkpf f // LOCUS NP_013013 345 aa linear PLN 30-JUN-2025 DEFINITION metalloendopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013013 VERSION NP_013013.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179877.1 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 345) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09237. On Jul 26, 2004 this sequence version replaced NP_013013.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..345 /product="metalloendopeptidase" /calculated_mol_wt="39197" Region 132..323 /region_name="M48C_Oma1_like" /note="Peptidase M48C, integral membrane endopeptidase; cd07331" /db_xref="CDD:320690" Site order(203..204,207,257,261,306) /site_type="active" /note="putative active site [active]" /db_xref="CDD:320690" Site order(203,207,257,306) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:320690" CDS 1..345 /gene="OMA1" /locus_tag="YKR087C" /coded_by="NM_001179877.1:1..1038" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12963738]" /experiment="EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:12963738]" /experiment="EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:27325672]" /experiment="EXISTENCE:mutant phenotype:GO:0035694 mitochondrial protein catabolic process [PMID:27325672]" /experiment="EXISTENCE:mutant phenotype:GO:0141164 mitochondrial protein quality control [PMID:12963738]" /note="Metalloendopeptidase of the mitochondrial inner membrane; important for adaptive responses to various homeostatic insults, preservation of normal mitochondrial function under damage-eliciting conditions, and stability of respiratory supercomplexes; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; zebrafish ortholog has a role in organ development and mouse ortholog is also required for respiratory supercomplex stability" /db_xref="GeneID:853962" /db_xref="SGD:S000001795" ORIGIN 1 mlrniirfkg fgkgtsggfl kpvsfrvqlt rcyrydngps yrrfnngeys qkssfksill 61 dkssrkylal lfggcslfyy thldkapvsd rsrfiwvsrp leltignyty ksiwrqtqqe 121 ilppqhplsi kienifmkiv eaaykdpsvd nslldgikwe ihvvndptas pnafvlpggk 181 vfifssilpi canddgiatv lahefahqla rhtaenlska piysllglvl ytvtgahain 241 nilldgflrm pasrqmetea dyiglmimsr acfqpqesik vwermanfek qmnrggvvnm 301 eflsthpast rrienmskwl pkaneiyeqs dcssmgnyyk sffsm // LOCUS NP_013014 337 aa linear PLN 30-JUN-2025 DEFINITION Tvp38p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013014 VERSION NP_013014.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179878.3 REFERENCE 1 (residues 1 to 337) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 337) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 337) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 337) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09238. On Jul 30, 2012 this sequence version replaced NP_013014.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..337 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..337 /product="Tvp38p" /calculated_mol_wt="38180" Region <27..>59 /region_name="DUF5828" /note="Family of unknown function (DUF5828); pfam19146" /db_xref="CDD:437006" Region <138..278 /region_name="TVP38" /note="Uncharacterized membrane protein YdjX, related to fungal oxalate transporter, TVP38/TMEM64 family [Function unknown]; COG0398" /db_xref="CDD:440167" CDS 1..337 /gene="TVP38" /locus_tag="YKR088C" /coded_by="NM_001179878.3:1..1014" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17178117]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:18194531]" /note="Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern" /db_xref="GeneID:853963" /db_xref="SGD:S000001796" ORIGIN 1 msqsyeagna nmgqgeddef dgyfedfdnd impnsnngqr vgtnaglsfn devnvndddf 61 ldiynmspre rlmhnirknv qklqfyfysl rlwqqiiivl lgimlmimgi lllvfhnail 121 hkvvvtsndl rekmsthfil mvliffvafp pmigysllst ttgliygvsf egwvtlalgs 181 vtgsiasfvv fktilhsrae klvhlnrrfe alasilqenn sywilallrl cpfpysltng 241 aiagvygisv rnfsianiit tpklfiylfi gsrvkslaes estgsrvfdl vsiiitllil 301 sltawllyfk tkkrylelqn rdrqvstdql pelsfev // LOCUS NP_013015 910 aa linear PLN 30-JUN-2025 DEFINITION triacylglycerol lipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013015 VERSION NP_013015.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179879.1 REFERENCE 1 (residues 1 to 910) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 910) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 910) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 910) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09239. Method: conceptual translation. FEATURES Location/Qualifiers source 1..910 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..910 /product="triacylglycerol lipase" /EC_number="3.1.1.3" /calculated_mol_wt="102586" Region 139..275 /region_name="DUF3336" /note="Domain of unknown function (DUF3336); pfam11815" /db_xref="CDD:432096" Region 210..632 /region_name="Pat_TGL4-5_like" /note="Triacylglycerol lipase 4 and 5; cd07230" /db_xref="CDD:132868" Site order(287..288,290,315,470) /site_type="active" /db_xref="CDD:132868" Site 313..317 /site_type="other" /note="nucleophile elbow" /db_xref="CDD:132868" CDS 1..910 /gene="TGL4" /locus_tag="YKR089C" /gene_synonym="STC1" /coded_by="NM_001179879.1:1..2733" /experiment="EXISTENCE:direct assay:GO:0004771 sterol ester esterase activity [PMID:20332534]" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:16135509|PMID:20332534]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:16267052|PMID:24868093|PMID:14562095|PMID:16135509|P MID:24390141]" /experiment="EXISTENCE:direct assay:GO:0006642 triglyceride mobilization [PMID:16135509]" /experiment="EXISTENCE:direct assay:GO:0042171 lysophosphatidic acid acyltransferase activity [PMID:20332534]" /experiment="EXISTENCE:direct assay:GO:0047499 calcium-independent phospholipase A2 activity [PMID:20332534]" /experiment="EXISTENCE:genetic interaction:GO:0007114 cell budding [PMID:19150427]" /experiment="EXISTENCE:genetic interaction:GO:0019433 triglyceride catabolic process [PMID:16267052]" /experiment="EXISTENCE:mutant phenotype:GO:0004771 sterol ester esterase activity [PMID:20332534]" /experiment="EXISTENCE:mutant phenotype:GO:0004806 triacylglycerol lipase activity [PMID:20332534|PMID:16135509]" /experiment="EXISTENCE:mutant phenotype:GO:0006642 triglyceride mobilization [PMID:16135509]" /experiment="EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:20332534]" /experiment="EXISTENCE:mutant phenotype:GO:0007114 cell budding [PMID:19150427]" /experiment="EXISTENCE:mutant phenotype:GO:0019433 triglyceride catabolic process [PMID:16267052]" /experiment="EXISTENCE:mutant phenotype:GO:0047499 calcium-independent phospholipase A2 activity [PMID:20332534]" /note="Multifunctional lipase/hydrolase/phospholipase; triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p; TGL4 has a paralog, TGL5, that arose from the whole genome duplication" /db_xref="GeneID:853964" /db_xref="SGD:S000001797" ORIGIN 1 msskisdlts tqnkpllvtq qliekyyeqi lgtsqniipi lnpknkfirp skdnsdverv 61 eedagkrlqt gknkttnkvn fnldtgnedk ldddqetvte nenndiemve tdegederqg 121 sslaskcksf lynvfvgnye rdilidkvcs qkqhamsfee wcsagarldd ltgktewkqk 181 lesplydykl ikdltsrmre erlnrnyaql lyiirtnwvr nlgnmgnvnl yrhshvgtky 241 lideymmesr laleslmesd lddsyllgil qqtrrnigrt alvlsgggtf glfhigvlgt 301 lfeldllprv isgssagaiv asilsvhhke eipvllnhil dkefnifkdd kqksesenll 361 ikisrffkng twfdnkhlvn tmieflgdlt freaynrtgk ilnitvspas lfeqprllnn 421 ltapnvliws avcascslpg ifpssplyek dpktgerkpw tgsssvkfvd gsvdndlpis 481 rlsemfnvdh iiacqvnihv fpflklslsc vggeiedefs arlkqnlssi ynfmaneaih 541 ileigsemgi aknaltklrs vlsqqysgdi tilpdmcmlf rikellsnpt kefllreitn 601 gakatwpkvs iiqnhcgqef aldkaisyik grmivtsslk tpfqfadsvi glikapeqts 661 desknpenst lltrtptkgd nhisnvlddn llesestnsl lllrenasty grspsgfrpr 721 ysitsaslnp rhqrrksdti stsrrpaksf sfsvasptsr mlrqssking hpppilqkkt 781 smgrlmfpmd aktydpeshe liphsasiet pamvdkklhf grksrylrhm nkkwvsssni 841 lytdsdkedh ptlrlisnfd sdamihsdla gnfrrhsidg rppsqatkss pfrsrpssst 901 qhksttsftq // LOCUS NP_013016 706 aa linear PLN 30-JUN-2025 DEFINITION Pxl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013016 VERSION NP_013016.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179880.4 REFERENCE 1 (residues 1 to 706) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 706) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 706) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 706) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09240. On Jul 30, 2012 this sequence version replaced NP_013016.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..706 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..706 /product="Pxl1p" /calculated_mol_wt="79303" Region 556..614 /region_name="LIM1_UF1" /note="LIM domain in proteins of unknown function; cd09397" /db_xref="CDD:188783" Site order(556,559,581,584,587,590,609,612) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:188783" Region 621..672 /region_name="LIM" /note="LIM is a small protein-protein interaction domain, containing two zinc fingers; cd08368" /db_xref="CDD:259829" Site order(621,624,642,645,648,651,669,672) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:259829" CDS 1..706 /gene="PXL1" /locus_tag="YKR090W" /coded_by="NM_001179880.4:1..2121" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:14767053]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23613772|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15282802|PMID:22842922|PMID:14767053]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095|PMID:14767053|PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:23613772]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:14767053]" /experiment="EXISTENCE:genetic interaction:GO:0005094 Rho GDP-dissociation inhibitor activity [PMID:15215315]" /experiment="EXISTENCE:genetic interaction:GO:0035023 regulation of Rho protein signal transduction [PMID:15215315]" /experiment="EXISTENCE:mutant phenotype:GO:0030011 maintenance of cell polarity [PMID:14767053]" /experiment="EXISTENCE:physical interaction:GO:0035023 regulation of Rho protein signal transduction [PMID:15215315]" /note="Protein that localizes to sites of polarized growth; required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; contains LIM domains and has similarity to metazoan paxillin; relocalizes from bud neck to cytoplasm upon DNA replication stress" /db_xref="GeneID:853965" /db_xref="SGD:S000001798" ORIGIN 1 mynsiygspf pkinpkvryk taleragfdt kprnpfssqr nastgslqas vksppitrqr 61 nvsaapsvpv tmksaytass ksayssvkge sdiypppvle nserrsvtpp knsnftssrp 121 sdisrsisrp serasqedpf rferdldrqa eqyaasrhtc kspankefqa adnfpfnfeq 181 edagntereq dlspiersfm mltqndtasv vnsmnqtdnr gvldqklgke qqkeessiey 241 esegqqeden dieslnfepd pklqmnlene plqddfpeak qeekntepki peinvtresn 301 tpsltmnald skiypddnfs glesskeqks pgvsssstkv edlsldglne krlsitssen 361 vetpytatnl qveqliaqld dvslsrnakl dmngnclnav drkasrfkks saylsgypsm 421 dipvtqqtsi vqnsntnlsr qtilvdkgdv dedapsestt nggtpifykf kqsnveysnn 481 egmgsqetfr tklptiealq lqhkrnitdl reeidnsksn dshvlpnggt tryssdadyk 541 etepiefkyp pgegpcracg levtgkrmfs kkenelsgqw hrecfkciec gikfnkhvpc 601 yilgdepycq khyheenhsi ckvcsnfieg eclendkver fhvdclncfl cktaitndyy 661 ifngeiplcg nhdmeallke gidnatssnd knntlskrrt rlinfn // LOCUS NP_013017 246 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding protein SRL3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013017 VERSION NP_013017.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179881.1 REFERENCE 1 (residues 1 to 246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 246) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09241. On Jul 26, 2004 this sequence version replaced NP_013017.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..246 /product="DNA-binding protein SRL3" /calculated_mol_wt="27335" CDS 1..246 /gene="SRL3" /locus_tag="YKR091W" /gene_synonym="WHI7" /coded_by="NM_001179881.1:1..741" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:23382076]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:39819572]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0006139 nucleobase-containing compound metabolic process [PMID:9744871]" /note="START transcriptional repressor; binds SBF (Swi4p-Swi6p) at SCB promoter elements in G1 to repress transcription; retains Cdc28-Cln3 at the ER and acts with Ydj1p to release Cln3p from the ER at critical size in a positive feedback loop to trigger START; unstable and degraded by SCF-Grr1 after hyperphosphorylation; contains a G1/S transcription factor binding (GTB) motif; binds SBF-regulated promoters in HU-treated cells; cell wall stress enhances repressor function; Cdc28p and Pho85p substrate" /db_xref="GeneID:853966" /db_xref="SGD:S000001799" ORIGIN 1 mflktpnwet vnetpksrvl tinelispnl dtesnsllat parkyfktsi seaqdsptsa 61 pspdgnedpt yqynvqfhfp gpitpttprs knaemfpspt pplvsptavi eeenddsvre 121 fsrtlksrln camvklskeh eqvalipppp tekirkgsys nkfaakhrrc hsldeskkfl 181 ssledssaha aflkaisskh aksnrvdnvn vsplrwsshr rtqstqensl qevvaidtll 241 kmsssd // LOCUS NP_013018 406 aa linear PLN 30-JUN-2025 DEFINITION Srp40p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013018 VERSION NP_013018.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179882.3 REFERENCE 1 (residues 1 to 406) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 406) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 406) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 406) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09242. On Jul 30, 2012 this sequence version replaced NP_013018.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..406 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..406 /product="Srp40p" /calculated_mol_wt="40884" Region 334..404 /region_name="SRP40_C" /note="SRP40, C-terminal domain; pfam05022" /db_xref="CDD:461525" CDS 1..406 /gene="SRP40" /locus_tag="YKR092C" /coded_by="NM_001179882.3:1..1221" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:8702624]" /note="Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140" /db_xref="GeneID:853967" /db_xref="SGD:S000001800" ORIGIN 1 maskkikvde vpklsvkeke ieekssssss ssssssssss sssssssssg esssssssss 61 sssssdssds sdsessssss ssssssssss dsesssesds sssgssssss sssdessses 121 esedetkkra resdnedake tkkaktepes ssssessssg sssssesesg sesdsdssss 181 sssssdsesd sesdsqssss ssssdsssds dssssdsssd sdssssssss ssdsdsdsds 241 ssdsdssgss dsssssdsss destssdssd sdsdsdsgss seletkeata deskaeetpa 301 ssnestpsas ssssanklni pagtdeikeg qrkhfsrvdr skinfeawel tdntykgaag 361 twgekanekl grvrgkdftk nknkmkrgsy rggsitlesg sykfqd // LOCUS NP_013019 601 aa linear PLN 30-JUN-2025 DEFINITION Ptr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013019 VERSION NP_013019.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179883.1 REFERENCE 1 (residues 1 to 601) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 601) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 601) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 601) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 601) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 601) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 601) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09243. Method: conceptual translation. FEATURES Location/Qualifiers source 1..601 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..601 /product="Ptr2p" /calculated_mol_wt="67913" Region 79..554 /region_name="MFS_PTR2" /note="Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; cd17350" /db_xref="CDD:340908" Site order(92..93,96..97,100,141,201..202,204..206,209,248, 251..252,255,358,361..362,365..367,370,397,401,479..480, 484,488,504,507..508,511..512,515) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340908" CDS 1..601 /gene="PTR2" /locus_tag="YKR093W" /coded_by="NM_001179883.1:1..1806" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340|PMID:17507646]" /experiment="EXISTENCE:direct assay:GO:0042937 tripeptide transmembrane transporter activity [PMID:16096264]" /experiment="EXISTENCE:direct assay:GO:0042938 dipeptide transport [PMID:16096264]" /experiment="EXISTENCE:direct assay:GO:0042939 tripeptide transport [PMID:16096264]" /experiment="EXISTENCE:direct assay:GO:0071916 dipeptide transmembrane transporter activity [PMID:16096264]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015833 peptide transport [PMID:8264579]" /experiment="EXISTENCE:mutant phenotype:GO:1904680 peptide transmembrane transporter activity [PMID:8264579]" /note="Integral membrane peptide transporter; mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by N-end rule pathway via repression by Cup9p; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:853968" /db_xref="SGD:S000001801" ORIGIN 1 mlnhpsqgsd daqdekqgdf pvieeektqa vtlkdsyvsd dvansteryn lspspededf 61 egpteeemqt lrhvggkipm rcwliaivel serfsyygls apfqnymeyg pndspkgvls 121 lnsqgatgls yffqfwcyvt pvfggyvadt fwgkynticc gtaiyiagif ilfitsipsv 181 gnrdsaiggf iaaiiligia tgmikanlsv liadqlpkrk psikvlksge rvivdsnitl 241 qnvfmffyfm invgslslma tteleyhkgf waayllpfcf fwiavvtlif gkkqyiqrpi 301 gdkviaksfk vcwiltknkf dfnaakpsvh peknypwndk fvdeikrala ackvfifypi 361 ywtqygtmis sfitqasmme lhgipndflq afdsialiif ipifekfvyp firrytplkp 421 itkiffgfmf gsfamtwaav lqsfvykagp wyneplghnt pnhvhvcwqi payvlisfse 481 ifasitgley ayskapasmk sfimsifllt nafgsaigca lspvtvdpkf twlftglava 541 cfisgclfwl cfrkyndtee emnamdyeee defdlnpisa pkandieile pmeslrsttk 601 y // LOCUS NP_013020 128 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-60S ribosomal protein eL40 RPL40B fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013020 VERSION NP_013020.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179884.3 REFERENCE 1 (residues 1 to 128) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 128) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 128) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 128) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09244. On Jul 30, 2012 this sequence version replaced NP_013020.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..128 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..128 /product="ubiquitin-60S ribosomal protein eL40 RPL40B fusion protein" /calculated_mol_wt="14423" Region 1..76 /region_name="Ubl_ubiquitin" /note="ubiquitin-like (Ubl) domain found in ubiquitin; cd01803" /db_xref="CDD:340501" Site order(6..9,11,34..37,40,42,44,46..49,68..76) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:340501" Site order(8..12,31..35,40,42,44,46..49,68,70..76) /site_type="other" /note="E1 interaction site [polypeptide binding]" /db_xref="CDD:340501" Region 79..126 /region_name="Ribosomal_L40e" /note="Ribosomal L40e family; pfam01020" /db_xref="CDD:395807" CDS 1..128 /gene="RPL40B" /locus_tag="YKR094C" /gene_synonym="CEP52B; UB12; UBI2" /coded_by="NM_001179884.3:1..387" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:22096102]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:2538753]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:22995916]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:22995916]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:8035826]" /note="Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication" /db_xref="GeneID:853969" /db_xref="SGD:S000001802" ORIGIN 1 mqifvktltg ktitlevess dtidnvkski qdkegippdq qrlifagkql edgrtlsdyn 61 iqkestlhlv lrlrggiiep slkalaskyn cdksvcrkcy arlppratnc rkrkcghtnq 121 lrpkkklk // LOCUS NP_013021 1875 aa linear PLN 30-JUN-2025 DEFINITION Mlp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013021 VERSION NP_013021.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179885.1 REFERENCE 1 (residues 1 to 1875) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1875) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1875) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1875) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09245. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1875 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1875 /product="Mlp1p" /calculated_mol_wt="218326" Region 111..>335 /region_name="EnvC" /note="Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]; COG4942" /db_xref="CDD:443969" Region 238..984 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 753..>1496 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 1001..1125 /region_name="TPR_MLP1_2" /note="TPR/MLP1/MLP2-like protein; pfam07926" /db_xref="CDD:462316" Region <1526..1838 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" CDS 1..1875 /gene="MLP1" /locus_tag="YKR095W" /gene_synonym="MPL1" /coded_by="NM_001179885.1:1..5628" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:10085285]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:10085285]" /experiment="EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:24152732]" /experiment="EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:10085285]" /experiment="EXISTENCE:genetic interaction:GO:0034398 telomere tethering at nuclear periphery [PMID:10638763]" /experiment="EXISTENCE:genetic interaction:GO:0043021 ribonucleoprotein complex binding [PMID:15692572]" /experiment="EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:14718167]" /experiment="EXISTENCE:genetic interaction:GO:1901925 negative regulation of protein import into nucleus during spindle assembly checkpoint [PMID:23177738]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:21036941]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:14718167]" /experiment="EXISTENCE:mutant phenotype:GO:0090204 protein localization to nuclear pore [PMID:19933151]" /experiment="EXISTENCE:mutant phenotype:GO:0140586 promoter-terminator loop anchoring activity [PMID:19933151]" /experiment="EXISTENCE:physical interaction:GO:0043021 ribonucleoprotein complex binding [PMID:15692572]" /note="Myosin-like protein associated with the nuclear envelope; nuclear basket protein that connects the nuclear pore complex (NPC) with the nuclear interior; involved with Tel1p in telomere length control; forms a coiled-coil parallel homodimer; recruitment and docking of Mlp1p filaments onto the NPC Y-complex involves Nup60p; involved along with Pml1p and Pml39p in nuclear retention of unspliced mRNAs; MLP1 has a paralog, MLP2, that arose from the whole genome duplication" /db_xref="GeneID:853970" /db_xref="SGD:S000001803" ORIGIN 1 msdhdtpmes iqngensder lnaiasffgc sleqvksfdg dvvkhlndkl lqfnelksen 61 lkvtvsfdel kasslkkidg lktemenvir endkirkern dtfvkfesve nekmklssel 121 efvkrklddl teekketqsn qqrtlkilde rlkeielvrv ennrsnseck klrstimdle 181 tkqqgyitnd lnsrtelerk tqeltllqsn ndwlekelrs kneqylsyrq ktdkvildir 241 nelnrlrndf qmertnndvl kqknnelsks lqeklleikg lsdslnsekq efsaemslkq 301 rlvdllesql navkeelnsi relntakvia ddskkqtpen edllkelqlt keklaqceke 361 clrlssitde adednenlsa ksssdfiflk kqlikerrtk ehlqnqietf ivelehkvpi 421 insfkertdm lenelnnaal llehtsnekn akvkelnakn qklvecendl qtltkqrldl 481 crqiqyllit nsvsndskgp lrkeeiqfiq nimqeddsti tesdsqkvvt erlvefknii 541 qlqeknaell kvvrnladkl eskekkskqs lqkiesetvn eakeaiitlk sekmdlesri 601 eelqkeleel ktsvpnedas ysnvtikqlt etkrdlesqv qdlqtrisqi trestenmsl 661 lnkeiqdlyd sksdisiklg kekssrilae erfkllsntl dltkaendql rkrfdylqnt 721 ilkqdskthe tlneyvscks klsivetell nlkeeqklrv hleknlkqel nklspekdsl 781 rimvtqlqtl qkeredllee trkscqkkid eledalselk ketsqkdhhi kqleednnsn 841 iewyqnkiea lkkdyesvit svdskqtdie klqykvksle keieedkirl htynvmdeti 901 nddslrkele kskinltday sqikeykdly ettsqslqqt nskldesfkd ftnqiknltd 961 ektsledkis llkeqmfnln neldlqkkgm ekekadfkkr isilqnnnke veavkseyes 1021 klskiqndld qqtiyantaq nnyeqelqkh advsktisel reqlhtykgq vktlnlsrdq 1081 lenalkenek swssqkesll eqldlsnsri edlssqnkll ydqiqiytaa dkevnnstng 1141 pglnnilitl rrerdildtk vtvaerdakm lrqkislmdv elqdartkld nsrvekenhs 1201 siiqqhddim eklnqlnllr esnitlrnel ennnnkkkel qseldklkqn vapieselta 1261 lkysmqekeq elklakeevh rwkkrsqdil ekheqlsssd yekleseien lkeelenker 1321 qgaeaeekfn rlrrqaqerl ktsklsqdsl teqvnslrda knvlenslse anarieelqn 1381 akvaqgnnql eairklqeda ekasrelqak leesttsyes tinglneeit tlkeeiekqr 1441 qiqqqlqats aneqndlsni vesmkksfee dkikfikekt qevnekilea qerlnqpsni 1501 nmeeikkkwe seheqevsqk ireaeealkk rirlpteeki nkiierkkee lekefeekve 1561 eriksmeqsg eidvvlrkql eakvqekqke leneynkklq eelkdvphss hisdderdkl 1621 raeiesrlre efnnelqaik kksfdegkqq ammkttller klakmesqls etkqsaespp 1681 ksvnnvqnpl lglprkieen snspfnplls gekllklnsk sssggfnpft spspnkhlqn 1741 dndkreslan ktdppthlep sfnipasrgl isssstlstd tndeeltsnn paqkdssnrn 1801 vqseedtekk kegepvkrge aieeqtksnk rpidevgelk ndeddtteni neskkikted 1861 eeeketdkvn densi // LOCUS NP_878113 88 aa linear PLN 30-JUN-2025 DEFINITION chromatin DNA-binding EKC/KEOPS complex subunit PCC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_878113 VERSION NP_878113.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184522.3 REFERENCE 1 (residues 1 to 88) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 88) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 88) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 88) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09246. On Jul 30, 2012 this sequence version replaced NP_878113.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..88 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..88 /product="chromatin DNA-binding EKC/KEOPS complex subunit PCC1" /calculated_mol_wt="9861" Region 12..85 /region_name="Pcc1" /note="Transcription factor Pcc1; pfam09341" /db_xref="CDD:462764" CDS 1..88 /gene="PCC1" /locus_tag="YKR095W-A" /coded_by="NM_001184522.3:1..267" /experiment="EXISTENCE:direct assay:GO:0000408 EKC/KEOPS complex [PMID:16874308]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16874308]" /experiment="EXISTENCE:direct assay:GO:0031490 chromatin DNA binding [PMID:16874308]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16874308]" /experiment="EXISTENCE:mutant phenotype:GO:0070525 tRNA threonylcarbamoyladenosine metabolic process [PMID:21459853|PMID:21183954]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:16874308]" /note="Component of the EKC/KEOPS protein complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; other complex members are Kae1p, Gon7p, Bud32p, and Cgi121p; ortholog of human LAGE3" /db_xref="GeneID:1500489" /db_xref="SGD:S000028512" ORIGIN 1 mtskreksld htlelkipfe terqatiatk vlspdpilkp qdfqvdysse knvmlvqfrs 61 iddrvlrvgv ssiidsikti veamdvls // LOCUS NP_013022 1195 aa linear PLN 30-JUN-2025 DEFINITION Esl2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013022 VERSION NP_013022.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179886.1 REFERENCE 1 (residues 1 to 1195) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1195) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1195) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1195) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09247. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1195 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1195 /product="Esl2p" /calculated_mol_wt="137361" Region 1027..1159 /region_name="PIN_SF" /note="PIN (PilT N terminus) domain: Superfamily; cl28905" /db_xref="CDD:475124" CDS 1..1195 /gene="ESL2" /locus_tag="YKR096W" /coded_by="NM_001179886.1:1..3588" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:22375831]" /note="hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl2p and Esl1p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; ESL2 has a paralog, ESL1, that arose from the whole genome duplication" /db_xref="GeneID:853971" /db_xref="SGD:S000001804" ORIGIN 1 mpetsvqnpl rlsenentrs mflsasqqqr psatpsfprl vrnttanlsl sdfqvlnpss 61 krqnsnsvyd dinsskrris rprfsdiegk nndhtypert tvkeseknps pryvssskra 121 lkrensvgit qssalisksf senggsiahe kwspenmikp lnvsqnslaf vdagsdeqsk 181 seivggfqrk snnsqeindk dnsardqdfn nsgnnnnnnn hssnnndnnn nnnddnnnnn 241 nsnsrdnnnn sddsnereen dsckpasnkr sgialiqklq elykvivkqe ielqercsql 301 tnsqttelks lwtiykintd lvnnyvtfit tallpsqpph dlvigqeive iyrierrlwv 361 ygtitfldvl knfsnfmdpe vccqfithvf vslstmisdi pskysitwlq rlgdlsrmai 421 alypssfidw klsaehwyte amkyiynhgk lyyhmstvqq ntleafvnlg ksvfcqetft 481 pspqymqlvi dniyqrafve rnngnlrnsl lieylkhsea mllpsflesp dlqnvvlsyf 541 iekfgidang cnifnaedmf vqnpdffkyf frhgpsfaqs hilqivgfge pknpfailfe 601 lpkylkerkd kkerkkssnn dssvtesstg nsrndneddd eimssttsis dhdllaeffn 661 didtlrrpil psmltneawl etlkflnmts lkcgiivlrk flhgplgial philpwiyfi 721 isiclkssql sdpvskefwm iivkrafpwd tmvtfmnvli vylldnqtsn siigdlcddy 781 dklslselle lfnegeelpe ilgcwgtlwf dticeknths issednfqei gikdymalds 841 ptdgiifdek dengekfwkr acrtiflfre lsrsfpigvi irndpliyrs sfqntnilgs 901 lvfkleplcn ihnnipvlga lesiidisea rsenntdlha vpelsvnegd nifhyvgykk 961 lradytcfdk ngeflsasly ttwyvpnsnn tniedninyn sekeneglfl eciksdypei 1021 dfkttyfvfd atswlrhsar ifklaqnrll rfaiclttfq elrflrkskd envmeaatrg 1081 iitirqlyye nkvlplrftg nvathieenl efeeqitwrt hvdefviesv mkaqeklesa 1141 seprlsprrf nyvvlisddd amkkkaeeke iktlstrfvf slctklgeqr hlctd // LOCUS NP_013023 549 aa linear PLN 30-JUN-2025 DEFINITION phosphoenolpyruvate carboxykinase PCK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013023 VERSION NP_013023.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179887.3 REFERENCE 1 (residues 1 to 549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 549) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09248. On Jul 30, 2012 this sequence version replaced NP_013023.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..549 /product="phosphoenolpyruvate carboxykinase PCK1" /EC_number="4.1.1.49" /calculated_mol_wt="60852" Region 31..545 /region_name="PEPCK_ATP" /note="Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; cd00484" /db_xref="CDD:238270" Site order(70,207,209,212..213,233,252..258,270..271,288,290, 299,336,457,460,463) /site_type="active" /db_xref="CDD:238270" Site order(70,207,209,212..213,288,336) /site_type="other" /note="substrate-binding site [chemical binding]" /db_xref="CDD:238270" Site order(213,233,257,270..271,288) /site_type="metal-binding" /note="metal-binding site [ion binding]" /db_xref="CDD:238270" Site order(252..258,299,457,463) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238270" CDS 1..549 /gene="PCK1" /locus_tag="YKR097W" /gene_synonym="JPM2; PPC1" /coded_by="NM_001179887.3:1..1650" /experiment="EXISTENCE:direct assay:GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity [PMID:16330239]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:196563]" /experiment="EXISTENCE:expression pattern:GO:0006094 gluconeogenesis [PMID:2689220]" /experiment="EXISTENCE:mutant phenotype:GO:0004612 phosphoenolpyruvate carboxykinase (ATP) activity [PMID:2689220]" /note="Phosphoenolpyruvate carboxykinase; key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol" /db_xref="GeneID:853972" /db_xref="SGD:S000001805" ORIGIN 1 mspskmnatv gstseveqki rqelalsdev ttirrnapaa vlyedglken ktvisssgal 61 iaysgvktgr spkdkrivee ptskdeiwwg pvnkpcsert wsinreraad ylrtrdhiyi 121 vdafagwdpk yrikvrvvca rayhalfmtn mlirpteeel ahfgepdftv wnagqfpanl 181 htqdmsskst ieinfkamem iilgteyage mkkgiftvmf ylmpvhhnvl tlhssanqgi 241 qngdvtlffg lsgtgkttls adphrlligd dehcwsdhgv fnieggcyak cinlsaekep 301 eifdaikfgs vlenviydek shvvdyddss itentrcayp idyipsakip cladshpkni 361 illtcdasgv lppvskltpe qvmyhfisgy tskmagteqg vtepeptfss cfgqpflalh 421 piryatmlat kmsqhkanay lintgwtgss yvsggkrcpl kytraildsi hdgslanety 481 etlpifnlqv ptkvngvpae llnpaknwsq geskyrgavt nlanlfvqnf kiyqdratpd 541 vlaagpqfe // LOCUS NP_013024 717 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease UBP11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013024 VERSION NP_013024.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179888.1 REFERENCE 1 (residues 1 to 717) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 717) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 717) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 717) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09249. Method: conceptual translation. FEATURES Location/Qualifiers source 1..717 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..717 /product="ubiquitin-specific protease UBP11" /EC_number="3.4.19.12" /calculated_mol_wt="82572" Region 298..704 /region_name="UCH" /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443" /db_xref="CDD:425685" Site order(302,307,649,674) /site_type="active" /db_xref="CDD:239072" CDS 1..717 /gene="UBP11" /locus_tag="YKR098C" /coded_by="NM_001179888.1:1..2154" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:10527495]" /note="Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication" /db_xref="GeneID:853973" /db_xref="SGD:S000001806" ORIGIN 1 mllnpdqiln lvrkvyevdi kqfysqlrlk nlrglldhaa hlfnvylrdl einqemealt 61 afiigcyyly liipqslqfq trnnlyssya klkndyqdeh vmgyvlkvvr destvivdry 121 laesngicrt ikrkrayslp lrplpvhmas lsihnkfdgs lheipneltk ptndnskedi 181 vresnqiass nkleagseva yytskealsk psylklstgk dalfktlssp atappvhsle 241 vssqirdssq dsssslskve kpkeeegkie aiessapkay nlpviedsnd llselsitgl 301 qnpcntcyin siiqclfgtt lfrdlfltkk yrlflntnky pkevqlsrsi yvlfkkmyln 361 ggraiipnrf lkmckklrpd lnipddqqdt qefllivlar iheelsnenv vkyypdlvsy 421 danalqvnps kyekwyernv itdglspidh iyrgqlenil kcqrcgnssy systfyvlsl 481 aipklslysf tsksrkikle dcinlftgde elsgdnawdc pncritdsks kkeeitsqkk 541 kstifgfhsr srsksphhhh hhhhssddst knakkrnskk lttiksldfi vlppilvihl 601 srfyydltkk nstvitypli lniilkngkv iryklygtvn hsgnlinghy tsvvnkeksh 661 eiglnrqvwv tfdddyiqqh rkdrnnfeag ktemssdevy vlfyermdee nyeeefc // LOCUS NP_013025 811 aa linear PLN 30-JUN-2025 DEFINITION Bas1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013025 VERSION NP_013025.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179889.3 REFERENCE 1 (residues 1 to 811) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 811) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 811) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 811) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09250. On Jul 30, 2012 this sequence version replaced NP_013025.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..811 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..811 /product="Bas1p" /calculated_mol_wt="89473" Region 17..585 /region_name="REB1" /note="Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]; COG5147" /db_xref="CDD:227476" CDS 1..811 /gene="BAS1" /locus_tag="YKR099W" /coded_by="NM_001179889.3:1..2436" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:2683089|PMID:1495962]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:1495962]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9705508]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1495962]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3303332]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:1495962]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1495962|PMID:3303332]" /note="Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; controls cellular ATP levels; also involved in regulation of meiotic recombination at specific genes" /db_xref="GeneID:853974" /db_xref="SGD:S000001807" ORIGIN 1 msnistkdir kskpkrgsgf dllevteslg yqthrkngrn swskdddnml rslvnesake 61 lgyengledv ktiqqsnhls kciawdvlat rfkhtvrtsk dvrkrwtgsl dpnlkkgkwt 121 qeedeqllka yeehgphwls ismdipgrte dqcakryiev lgpgskgrlr ewtleedlnl 181 iskvkaygtk wrkissemef rpsltcrnrw rkiitmvvrg qasevitkai kenknidmtd 241 gklrqhpiad sdirsdstpn keeqlqlsqq nnpslikqdi lnvkenessk lprlkdndgp 301 ilndskpqal pplkeisapp pirmtqvgqt htsgsirskv slpieglsqm nkqspggisd 361 spqtslppaf npasldehmm nsnsisdspk haystvktre pnssstqwkf tlkdgqglsi 421 sngtidstkl vkelvdqakk yslkisihqh ihnhyvtstd hpvssntgls nigningnpl 481 lmdsfphmgr qlgnglpgln snsdtfnpey rtsldnmdsd flsrtpnyna fsleatshnp 541 adnanelgsq snretnspsv fypqantlip tnstatnnei iqgnvsansm spnfngtngk 601 apsstasytt sgsemppdvg pnriahfnyl pptirphlgs sdatrgadln kllnpspnsv 661 rsngsktkkk ekrksessqh hssssvttnk fnhidqseis rttsrsdtpl rdedgldfwe 721 tlrslattnp nppveksaen dgakpqvvhq gigshtedss lgshsggydf fnelldkkad 781 tlhneakkts ehdmtsggst dngsvlplnp s // LOCUS NP_013026 355 aa linear PLN 30-JUN-2025 DEFINITION Skg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013026 VERSION NP_013026.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179890.1 REFERENCE 1 (residues 1 to 355) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 355) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 355) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 355) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09251. On Feb 23, 2004 this sequence version replaced NP_013026.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..355 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..355 /product="Skg1p" /calculated_mol_wt="39698" Region 3..>42 /region_name="SKG6" /note="SKG6 family; pfam08693" /db_xref="CDD:462564" CDS 1..355 /gene="SKG1" /locus_tag="YKR100C" /gene_synonym="YKR099C-A" /coded_by="NM_001179890.1:1..1068" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15645486]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15645486]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:15645486]" /note="Transmembrane protein with a role in cell wall polymer composition; localizes on inner surface of plasma membrane at bud and in daughter cell; SKG1 has a paralog, AIM20, that arose from the whole genome duplication" /db_xref="GeneID:853975" /db_xref="SGD:S000001808" ORIGIN 1 mtastsvavg cavgipvgvg iiiavcfwfn lqkrykreeq ddreleraiy desgfvsfdn 61 fgplrdskde aalasselkn pdhtsgsseg sahpeekdgk srdqekplgk knskyyvpay 121 rrkinllqvr nnnygnnarq ksvvdlpsin nssnvslsss qrhitkrqis vydqmvpvis 181 degpnffadp ssdtntsndq nkasmielkh ntrqssnenl irnlqnqdfg syyprrasss 241 flngnisnas fhtrnssits vnkrdaledv fatpksaaqs qlpntfdkdn egmdadhsvk 301 dsrsaitdkd kdlyklqnny dvgnigeiae edqyeneftn ysqskrefie slrpk // LOCUS NP_013027 654 aa linear PLN 30-JUN-2025 DEFINITION Sir1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013027 VERSION NP_013027.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179891.3 REFERENCE 1 (residues 1 to 654) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 654) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 654) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 654) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09252. On Jul 30, 2012 this sequence version replaced NP_013027.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..654 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..654 /product="Sir1p" /calculated_mol_wt="76803" Region 3..125 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 157..>228 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 465..585 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" CDS 1..654 /gene="SIR1" /locus_tag="YKR101W" /coded_by="NM_001179891.3:1..1965" /experiment="EXISTENCE:direct assay:GO:0005677 chromatin silencing complex [PMID:8622770]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:3297920]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:2684414]" /note="Protein involved in silencing at mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin" /db_xref="GeneID:853976" /db_xref="SGD:S000001809" ORIGIN 1 mlqinsrlav idgwlvdtvk rkpinfrspe vrlllpnddd ykklsqqnlv dwtrlkkdsn 61 svlvgvksme lfkhiklvlr efflledgri ilkrirsklr ykvvkkltck ccrlylpkwg 121 tvyihpmlkd kekplagvce fsldvnpdre yplieinvsh qyiiiegfll ylnerrlyrw 181 ndnnlrsqvg ltkwahlrkt ynpvsldily slnsnfyfvk ddllfqllgk rvfvkfckvm 241 engkcgkapl wyrvkrttta kathiayais nstapdsfks knndyrfivr ekpiventis 301 nldysdikkq qfteaevvkr kisadisqie nvhtqfnsqk eknnirvnkv ssevldqisk 361 fpvsrvtlll msagqdknyi elveelarrl ekiciekttq sleeirdtfq anpemqasfd 421 keyyqsieey kitleliked llitlikqme nmwaaekkfs teeeyvsprf lvadgflidl 481 aeekpinpkd prlltllkdh qramidqmnl vkwndfkkyq dpiplkaktl fkfckqikkk 541 flrgadfklh tlpteanlky epermtvlcs cvpillddqt vqylyddsii pefeatssya 601 tkqskcgrkm slqmepdllf qeairrmrhl taydvlrrny iaafeelymg ncnd // LOCUS NP_013028 1169 aa linear PLN 30-JUN-2025 DEFINITION Flo10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013028 VERSION NP_013028.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179892.1 REFERENCE 1 (residues 1 to 1169) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1169) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1169) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1169) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09253. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1169 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1169 /product="Flo10p" /calculated_mol_wt="122034" Region 135..271 /region_name="PA14" /note="PA14 domain; pfam07691" /db_xref="CDD:400161" Region 937..980 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" Region 996..1037 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" CDS 1..1169 /gene="FLO10" /locus_tag="YKR102W" /coded_by="NM_001179892.1:1..3510" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000128 flocculation [PMID:19087208|PMID:19420680|PMID:11027318]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:11027318|PMID:19087208]" /experiment="EXISTENCE:mutant phenotype:GO:0044182 filamentous growth of a population of unicellular organisms [PMID:11027318]" /note="Member of the FLO family of cell wall flocculation proteins; not expressed in most lab strains; overproduction induces flocculation that can be inhibited by mannose, sucrose, or glucose; overproduction also promotes haploid invasive growth and diploid filamentous growth" /db_xref="GeneID:853977" /db_xref="SGD:S000001810" ORIGIN 1 mpvaaryifl tglfllsvan valgtteacl pagekkngmt infyqyslkd sstysnpsym 61 aygyadaekl gsvsgqtkls idysipcnga sdtcacsddd ateysasqvv pvkrgvklcs 121 dnttlsskte krenddcdqg aaywssdlfg fyttptnvtv emtgyflppk tgtytfgfat 181 vddsailsvg gnvafecckq eqppitstdf tingikpwna daptdikgst ymyagyyypi 241 kivysnavsw gtlpvsvvlp dgtevnddfe gyvfsfddna tqahcsvpnp aehartcvss 301 atsswsssev ctectetest syvtpyvtss swsssevcte cteteststs tpyvtsssss 361 ssevctecte testsyvtpy vssstaaany tssfssssev ctectetest ststpyvtss 421 swsssevcte ctetestsyv tpyvssstaa anytssfsss sevctectet estststpyv 481 tsssssssev ctectetest syvtpyvsss taaanytssf ssssevctec teteststst 541 pyvtssswss sevctectet estsyvtpyv ssstaaanyt ssfssssevc tectetests 601 tstpyatsst gtatsftast sntmtslvqt dttvsfslss tvsehtnapt ssvesnastf 661 issnkgsvks yvtssihsit pmypsnqtvt sssvvstpit sessessasv tilpstitse 721 fkpstmktkv vsisssptnl itsydttskd stvgsstssv slissislps sysasseqif 781 hssivssngq altsfsstkv sssesseshr tspttssesg ikssgveies tstssfsfhe 841 tstastsvqi ssqfvtpssp istvaprstg lnsqtestns sketmssens asvmpsssat 901 spktgkvtsd etssgfsrdr ttvyrmtset pstneqttli tvsscesnsc sntvssavvs 961 tatttingit teyttwcpls atelttvskl eseekttlit vtscesgvcs etaspaivst 1021 atatvndvvt vystwspqat nklavssdie nsaskasfvs eaaetksisr nnnfvptsgt 1081 tsiethtttt snasensdnv saseavssks vtnpvlisvs qqprgtpass migsstasle 1141 mssylgianh lltnsgisif iaslllaiv // LOCUS NP_013029 1218 aa linear PLN 30-JUN-2025 DEFINITION putative multidrug transporter NFT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013029 VERSION NP_013029.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179893.3 REFERENCE 1 (residues 1 to 1218) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1218) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 1218) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 1218) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09254. On Jul 30, 2012 this sequence version replaced NP_013029.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1218 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..1218 /product="putative multidrug transporter NFT1" /calculated_mol_wt="137866" Region 252..>1218 /region_name="MRP_assoc_pro" /note="multi drug resistance-associated protein (MRP); TIGR00957" /db_xref="CDD:188098" CDS 1..1218 /gene="NFT1" /locus_tag="YKR103W" /coded_by="NM_001179893.3:1..3657" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23658021]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /note="Putative transporter of the MRP subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein" /db_xref="GeneID:853978" /db_xref="SGD:S000001811" ORIGIN 1 mikngtcpyw erddlsecar reyiefkfpl filltgmiya fckvfrafyl rgknhtneap 61 efeeqgngnh eyarfsvlrl ksawesrsfc nvnnrstfdk fkkfiegafi vlqltihlyi 121 lssmpmdnkk ffhqgflvqm flwilllvvi tlrlisasqs frwvlackrd lwavsfysya 181 slftlsilpl rsvfigkikd kimvkyiise tfidlallll lstssiegtr ysflvenenk 241 klppaptvfg lltfsridrl iwkaykhclg nadiwdldin nksiailanf emsskkgrll 301 pniicyfkav fisqlflafv ssflnfvpsl lmprilsyvn dpkskswnlv slyvssmlvs 361 kiiattcrgq glflgekgtm qlrtvlisni ysktlrrtil kdsttslqkn astsfeenpd 421 sseaeprkks srkdnsvnnv msidafkvse amntfylace avfmtvtalm ilysllgwsa 481 fagtfallam iplnfwcatf ygnyqadqli ltdkrtsgis ealnsirvik llawenlfyq 541 kiinvrdgei rllkkkatif flnhliwffg ptlvsaitfs vfikfqnqtl tptiaftals 601 lfailrtpmd qiastvslli qsfisleriq dylnesetrk yeileqsntk fgfedasmew 661 eaaetsfklk nisidfklns lnaiigptgs gksslllgll gelnllsgki yvptvesrdd 721 leigkdgmtn smaycsqtpw lisgtikdnv vfgeifnkqk fddvmksccl dkdikamtag 781 irtdvgdggf slsggqqqri alaraiysss rylilddcls avdpetalyi yeeclcgpmm 841 kgrtciitsh nislvtkrad wlvildrgev ksqgkpsdli ksneflresi nndskntthn 901 qidlkrstts kktkngdpeg gnsqdevcae venfeetkme gsvkfsaykw ladyfgglgv 961 vfvftsssil ihgitlsqgf wlrywldtgs sgskstwlyr iveghsniyf lltyiiiglv 1021 ssfltsgkvw iaiisgtnvt kkifakllss ilyaklrfhn vtptgrimnr fskdmdiidq 1081 qlipnfegls ysvvvclwii lligyvtpqf llfaiplcal yytvctlylr asrelkridn 1141 inispihqlf aeaikgvtti raladerrfi tqslvaidrs napffylnma tewityrvdi 1201 igtlvlfsss vmiimkas // LOCUS NP_013030 306 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YKR104W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013030 VERSION NP_013030.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179894.1 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 306) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09255. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..306 /product="uncharacterized protein" /calculated_mol_wt="34521" Region 27..270 /region_name="ABCC_NFT1" /note="ATP-binding cassette domain 2 of NFT1, subfamily C; cd03369" /db_xref="CDD:213269" CDS 1..306 /locus_tag="YKR104W" /gene_synonym="NFT1" /coded_by="NM_001179894.1:1..921" /note="Putative transporter of the MRP subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein" /db_xref="GeneID:853979" /db_xref="SGD:S000001812" ORIGIN 1 mssverikey tdipsesngy isppanwpqt gdvelknlsl rysphsskal dnvsfkvkag 61 tkvgivgrtg agkssiiaai yrlsdwengt itidnkdikh iplerlrnsi scipqdptlf 121 dgtvrsnldp fdrysdvqiy gvlskvglie ecdelclife qeqpnfsshk lrnrfidlnt 181 vvksggsnls qgqrqllcla rsmlgarnim lideatasid yisdakiqkt iretmkntti 241 ltiahrlrsv idydkilvme mgrvkeydhp ytlisdrnti fyrlcrqsge fenlfelakv 301 sfdnkr // LOCUS NP_013031 582 aa linear PLN 30-JUN-2025 DEFINITION basic amino acid transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_013031 VERSION NP_013031.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179895.3 REFERENCE 1 (residues 1 to 582) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 582) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 582) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 582) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09256. On Jul 30, 2012 this sequence version replaced NP_013031.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..582 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..582 /product="basic amino acid transporter" /calculated_mol_wt="63230" Region 43..493 /region_name="MFS_Azr1_MDR_like" /note="Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17502" /db_xref="CDD:341045" Site order(50..51,54..55,58,89,139..140,142..144,147,167, 170..171,174,343,346..347,350..352,355,383,387,440..441, 445,449,471,474..475,478..479,482) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:341045" CDS 1..582 /gene="VBA5" /locus_tag="YKR105C" /coded_by="NM_001179895.3:1..1749" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23047103]" /experiment="EXISTENCE:genetic interaction:GO:1903826 L-arginine transmembrane transport [PMID:23047103]" /experiment="EXISTENCE:mutant phenotype:GO:1903826 L-arginine transmembrane transport [PMID:23047103]" /note="Plasma membrane protein of the Major Facilitator Superfamily (MFS); involved in amino acid uptake and drug sensitivity; VBA5 has a paralog, VBA3, that arose from a segmental duplication" /db_xref="GeneID:853980" /db_xref="SGD:S000001813" ORIGIN 1 meetkyssqq eiegacgsda slnargsnds pmglslylcl asltlvlfit aldilivgti 61 idvvaeqfgn ysktgwlvtg yslpnailsl iwgrfasiig fqhslilail ifeagsliaa 121 lassmnmlif grvvagvggs glqtlcfvig ctmvgersrp lvisilscaf avaaivgpii 181 ggaftthvtw rwcfyinlpi gglaiimfll tykaenkgil qqikdaigti ssftfskfrh 241 qvnfkrlmng iifkfdffgf alcsaglvlf llgltfggnk yswnsgqvit ylvlgvllfi 301 fslvydfflf dkfnpepdni syrplllrrl vakpaiiivn mvtfllctgy ngqmiysvqf 361 fqlifassaw kaglhlipiv itnviaaias gvitkklglv kpllifggvl gvigaglmtl 421 mtntstkstq igvlllpgfs lgfalqaslm saqlqitkdr peaamdfiev tafntfmksl 481 gttlggvlst tvfsasfhnk vsrahlepye gktvddmily rlqnydgshs tignilsdsi 541 knvfwmdlgf yalgflfcsf ssnkkliipk kddtpednle dk // LOCUS NP_013032 615 aa linear PLN 30-JUN-2025 DEFINITION glutathione exchanger [Saccharomyces cerevisiae S288C]. ACCESSION NP_013032 VERSION NP_013032.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001179896.1 REFERENCE 1 (residues 1 to 615) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 615) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 3 (residues 1 to 615) AUTHORS Dujon,B., Alexandraki,D., Andre,B., Ansorge,W., Baladron,V., Ballesta,J.P., Banrevi,A., Bolle,P.A., Bolotin-Fukuhara,M., Bossier,P. et al. TITLE Complete DNA sequence of yeast chromosome XI JOURNAL Nature 369 (6479), 371-378 (1994) PUBMED 8196765 REFERENCE 4 (residues 1 to 615) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09257. Method: conceptual translation. FEATURES Location/Qualifiers source 1..615 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XI" Protein 1..615 /product="glutathione exchanger" /calculated_mol_wt="68823" Region 59..571 /region_name="MFS_ARN_like" /note="Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; cd17322" /db_xref="CDD:340880" Site order(73..74,77..78,81,112,162..163,165..167,170,186, 189..190,193,352,355..356,359..361,364,392,396,450..451, 455,459,475,478..479,482..483,486) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340880" CDS 1..615 /gene="GEX2" /locus_tag="YKR106W" /coded_by="NM_001179896.1:1..1848" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:21490148]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21490148]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Proton:glutathione antiporter; localized to the vacuolar and plasma membranes; expressed at a very low level; potential role in resistance to oxidative stress and modulation of the PKA pathway; GEX2 has a paralog, GEX1, that arose from a segmental duplication" /db_xref="GeneID:853981" /db_xref="SGD:S000001814" ORIGIN 1 msssvvgass nkksgirqsc eiiererhsn ddtysmtstf fklkeneims aqfdslkyki 61 llistafvcg fgisldytlr stytgyatns ysehsllstv qvinavvsvg sqvvysrlsd 121 hfgrlrlflv atifyimgti iqsqatrltm yaagsvfync gyvgtnlllt lilsdfsslk 181 wrmfyqyasy wpyiiipwis gniitaanpq knwswniamw afiyplstlp iiflilymky 241 kssktaewrs lkeqarkert gglfenlvfl fwkldivgil litvslgcil vpltlanets 301 qkwhnskiia tlvsggclff iflyweakfa kspllpfkll sdrgiwaplg vtffnfftff 361 iscdylypvl lvsmkessts aarivnlpdf vaataspfys llvaktrklk lsviggcaaw 421 mvcmglfyky rggsgshegv iaasvimgls gllcsnsviv ilqamtthsr mavitgiqyt 481 fsklgaaiga svsgaiwtqt mpnqlyknlg ndtlaeiaya spytfisdyp wgsperdavv 541 esyryvqrii mtvglactvp fftftmfmrn pelidkathe eftedglvvl pdeenifsqi 601 kalfrhnrsn kksgc // LOCUS NP_013033 1205 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013033 VERSION NP_013033.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181887.1 REFERENCE 1 (residues 1 to 1205) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1205) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1205) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1205) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09258. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1205 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1205 /product="Y' element ATP-dependent helicase" /EC_number="3.6.4.12" /calculated_mol_wt="135106" Region 199..371 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Region 446..541 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1205 /locus_tag="YLL067C" /coded_by="NM_001181887.1:1..3618" /note="Putative Y' element ATP-dependent helicase" /db_xref="GeneID:850659" /db_xref="SGD:S000003990" ORIGIN 1 mrtftdfvsg apivrslqks tirrygynla phmflllhvd elsifsayqa slpgekkvdt 61 erlkrdlcpr kpieikyfsq icndmmnkkd rlgdvlataq rirrrynkng sseprlktld 121 gltserwiqw lglesdyhcs fsstrnaedv vageaassdh dqkisrvtrk rprepkstnd 181 ilvagqklfg ssfefrdlhq lrlcheiyma dtpsvavqap pgygktelfh lplialaskg 241 dvkyvsflfv pytvllancm irlgrcgcln vapvrnfiee gcdgvtdlyv giyddlastn 301 ftdriaawen ivectfrtnn vklgylivde fhnfetevyr qsqfggitnl dfdafekaif 361 lsgtapeava daalqriglt glakksmdin elkrsedlsr glssyptrmf nlikeksevp 421 lghvhkiwkk vesqpeealk lllalfeiep eskaivvast tneveelacs wrkyfrvvwi 481 hgklgaaekv srtkefvtdg smrvligtkl vtegidikql mmvimldnrl niieliqgvg 541 rlrdgglcyl lsrknswaar nrkgelppik egciteqvre fygleskkgk kgqhvgccgs 601 rtdlsadtve liermdrlae kqatasmsiv alpssfqesn ssdrcrkycs sdedsntcih 661 gsanastnat tnsstnattt astnvrtsat ttasinvrts atttestnss tnatttastn 721 vrtsatttas invrtsattt estnsntsat ttestdsnts atttestdss tnatttasin 781 vrtsatttes tnsntnattt estnsstnat ttegtnsnts atttastnss tnatttestn 841 asakedankd gnaednrfhp vtdinkesyk rkgsqmvlle rkklkaqfpn tsenmnvlqf 901 lgfrsdeikh lflygidvyf cpegvftqyg lckgcqkmfe lcvcwagqkv syrrmaweal 961 avermlrnde eykeyledie pyhgdpvgyl kffsvkrgei ysqiqrnyaw ylaitrrret 1021 isvldstrgk qgsqvfrmsg rqikelyykv wsnlreskte vlqyflnwde kkcreeweak 1081 ddtvfveale kvgvfqrlrs mtsaglqgpq yvklqfsrhh rqlrsryels lgmhlrdqla 1141 lgvtpskvph wtaflsmlig lfynktfrqk leylleqise vwllphwvdl anvevlaadn 1201 trvpc // LOCUS NP_878115 56 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLL066W-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878115 VERSION NP_878115.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184605.1 REFERENCE 1 (residues 1 to 56) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 56) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 56) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 56) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09259. Method: conceptual translation. FEATURES Location/Qualifiers source 1..56 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..56 /product="uncharacterized protein" /calculated_mol_wt="6280" CDS 1..56 /locus_tag="YLL066W-B" /coded_by="NM_001184605.1:1..171" /note="hypothetical protein; overexpression causes a cell cycle delay or arrest" /db_xref="GeneID:1466404" /db_xref="SGD:S000028672" ORIGIN 1 mslrpcltps smqysdiyih hthtphphht hththhtpth sltstftlav tpypaf // LOCUS NP_013034 1205 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013034 VERSION NP_013034.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181886.1 REFERENCE 1 (residues 1 to 1205) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1205) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1205) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1205) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09260. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1205 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1205 /product="Y' element ATP-dependent helicase" /EC_number="3.6.4.12" /calculated_mol_wt="135516" Region 199..371 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Region 446..541 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1205 /locus_tag="YLL066C" /coded_by="NM_001181886.1:1..3618" /note="Putative Y' element ATP-dependent helicase; YLL066C is not an essential gene" /db_xref="GeneID:850660" /db_xref="SGD:S000003989" ORIGIN 1 mrtftdfvsg apivrslqks tirrygynla phmflllhvd elsifsayqa slpgekkvdt 61 erlkrdlcpr kpieikyfsq icndmmnkkd rlgdvlataq rirrrynkng sseprlktld 121 gltserwiqw lglesdyhcs fsstrnaedv vageaassdh dqkisrvtrk rprepkstnd 181 ilvagqklfg ssfefrdlhq lrlcheiyma dtpsvavqap pgygktelfh lplialaskg 241 dvkyvsflfv pytvllancm irlgrcgcln vapvrnfiee gcdgvtdlyv giyddlastn 301 ftdriaawen ivectfrtnn vklgylivde fhnfetevyr qsqfggitnl dfdafekaif 361 lsgtapeava daalqriglt glakksmdin elkrsedlsr glssyptrmf nlikeksevp 421 lghvhkiwkk vesqpeealk lllalfeiep eskaivvast tneveelacs wrkyfrvvwi 481 hgklgaaekv srtkefvtdg smrvligtkl vtegidikql mmvimldnrl niieliqgvg 541 rlrdgglcyl lsrknswaar nrkgelppik egciteqvre fygleskkgk kgqhvgccgs 601 rtdlsadtve liermdrlae kqatasmsiv alpssfqesn ssdrcrkycs sdedsntcih 661 gsanastnat tnsstnattt astnvrtsat ttasinvrts atttestnss tnatttastn 721 vrtsatttas invrtsattt estnsntsat ttestdsnts atttestdsn tsatttastn 781 sstnatttas tnsstnattt estnasaked ankdgnaedn rfhpvtdink esykrkgsqm 841 vllerkklka qfpntsenmn vlqflgfrsd eikhlflygi diyfcpegvf tqyglckgcq 901 kmfglcvcwa gqkvsyrrma wealaverml rndeeykeyl ediepyhgdp vgylkffsvk 961 rgeiysqiqr nyawylaitr rretisvlds trgkqgsqvf rmsgrqikel yykvwsnlre 1021 sktevlqyfl nwdekkcree weakddtvfv ealekvgvfq rlrsmtsagl qgpqyvklqf 1081 srhhrqlrsr yelslgmhlr dqlalgvtps kvphwtafls mliglfynkt frqkleylle 1141 qisevwllph wvdlanvevl aadntrvply mlmvavhkel dsddvpdgrf diillcrdss 1201 revge // LOCUS NP_013036 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU18 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013036 VERSION NP_013036.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181884.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09261. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..120 /product="seripauperin PAU18" /calculated_mol_wt="12774" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU18" /locus_tag="YLL064C" /coded_by="NM_001181884.1:1..363" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p" /db_xref="GeneID:850662" /db_xref="SGD:S000003987" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ymfqaahpte 61 typvevaeav fnygdfttml tgiapdqvtr mitgvpwyst rlkpaiskal skdgiytian // LOCUS NP_013037 474 aa linear PLN 30-JUN-2025 DEFINITION acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013037 VERSION NP_013037.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181883.1 REFERENCE 1 (residues 1 to 474) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 474) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 474) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 474) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09262. Method: conceptual translation. FEATURES Location/Qualifiers source 1..474 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..474 /product="acetyltransferase" /calculated_mol_wt="52706" Region 2..452 /region_name="Transferase" /note="Transferase family; pfam02458" /db_xref="CDD:460564" CDS 1..474 /gene="AYT1" /locus_tag="YLL063C" /coded_by="NM_001181883.1:1..1425" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:mutant phenotype:GO:0043387 mycotoxin catabolic process [PMID:12478589]" /experiment="EXISTENCE:mutant phenotype:GO:0045462 trichothecene 3-O-acetyltransferase activity [PMID:12478589]" /note="Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis; localized to peroxisomes" /db_xref="GeneID:850663" /db_xref="SGD:S000003986" ORIGIN 1 mfrvkiisqk rtksvqmlen dqldilgqqp slyklytqic siyrvpdpsa hdhivntltr 61 gletlaknfq wlagnvvneg adegntgtyr ivpsdkipli vqdlredlsa ptmdslekad 121 fpiymldekt fapcmtinpp gntigmaaks gpvfavqanf isgglvltiv gqhnimditg 181 qesiinllnk schqkpfsde ellignidks ksiplfdetw epdttlvhei vetsrntsge 241 ekeqscssns twayvefsai slqnlrilam qtctsgtkfv stddivtafi wksvsrarls 301 rlkpetksnl gravdvrkrl glpetypgll vnmtfntgsl ksldhkslgv lasqirrkld 361 pkvfdlaynt calatllsrc pdktkvsipq pidtlsgimv sswakvslyd vdfnlglgkp 421 ksvrrprfis lesliyfmpr ssrgemvval clrdkdwecl nadkewtnya thig // LOCUS NP_013038 324 aa linear PLN 30-JUN-2025 DEFINITION S-adenosylmethionine-homocysteine S-methyltransferase MHT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013038 VERSION NP_013038.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181882.1 REFERENCE 1 (residues 1 to 324) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 324) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 324) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 324) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 324) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09263. Method: conceptual translation. FEATURES Location/Qualifiers source 1..324 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..324 /product="S-adenosylmethionine-homocysteine S-methyltransferase MHT1" /EC_number="2.1.1.10" /calculated_mol_wt="36584" Region 18..320 /region_name="S-methyl_trans" /note="Homocysteine S-methyltransferase; pfam02574" /db_xref="CDD:460598" CDS 1..324 /gene="MHT1" /locus_tag="YLL062C" /coded_by="NM_001181882.1:1..975" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity [PMID:11013242]" /experiment="EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:11013242]" /note="S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio" /db_xref="GeneID:850664" /db_xref="SGD:S000003985" ORIGIN 1 mkripikeli vehpgkvlil dggqgtelen rgininspvw saapftsesf wepssqerkv 61 veemyrdfmi aganilmtit yqanfqsise ntsiktlaay krfldkivsf trefigeery 121 ligsigpwaa hvsceytgdy gphpenidyy gffkpqlenf nqnrdidlig fetipnfhel 181 kailswdedi iskpfyigls vddnsllrdg ttleeisvhi kglgnkinkn lllmgvncvs 241 fnqsalilkm lhehlpgmpl lvypnsgeiy npkektwhrp tnklddwett vkkfvdngar 301 iiggccrtsp kdiaeiasav dkys // LOCUS NP_013039 583 aa linear PLN 30-JUN-2025 DEFINITION S-methylmethionine permease MMP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013039 VERSION NP_013039.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181881.1 REFERENCE 1 (residues 1 to 583) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 583) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 583) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 583) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09264. Method: conceptual translation. FEATURES Location/Qualifiers source 1..583 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..583 /product="S-methylmethionine permease MMP1" /calculated_mol_wt="64087" Region 70..547 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..583 /gene="MMP1" /locus_tag="YLL061W" /coded_by="NM_001181881.1:1..1752" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000100 S-methylmethionine transmembrane transporter activity [PMID:10497160]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:10497160]" /experiment="EXISTENCE:mutant phenotype:GO:0015806 S-methylmethionine transport [PMID:10497160]" /note="High-affinity S-methylmethionine permease; required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p" /db_xref="GeneID:850665" /db_xref="SGD:S000003984" ORIGIN 1 mdefestkls kvqfstsvls tpsnegnnli hrfknsfkrn dspaiqegll yselseeeki 61 qwdlanqpyk kvldqrhltm iaiggtlgtg lfiglgesla sgpaslligf llvgasmlcv 121 vqcgaelscq ypvsgsyalh asrfidpsvg fsiginyllm wlisypselv gcsltisywa 181 psvnpaawva iafvlsmlln lfgargfaes efymsifkiv alfifiiigi vliagggpds 241 tgyigtkywh dpgsfavpvf knlcntfvsa aysfsgtemv vltstearsv ssvsraakgt 301 fwriiifyiv tviiigclvp yndprlisgs sseditaspf vialsntgam gtrvshfmna 361 viliavfsvc nscvyassrl iqglatagql pkicaymdrn grplvgmaic gafgllgflv 421 vsknqgtvft wlfalcsisf fttwfcicfc qvrfrmamka qgrskddiiy rstlgiyggi 481 fgcilnvllv igeiyvsaap vgspssaanf feycmsipim iavyighriy rrdwrhwyik 541 rmdidldsgh sledfeatkl erdedkkyvs skplyyriyr ffc // LOCUS NP_013040 233 aa linear PLN 30-JUN-2025 DEFINITION glutathione transferase GTT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013040 VERSION NP_013040.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181880.1 REFERENCE 1 (residues 1 to 233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 233) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09265. Method: conceptual translation. FEATURES Location/Qualifiers source 1..233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..233 /product="glutathione transferase GTT2" /EC_number="2.5.1.18" /calculated_mol_wt="26209" Region 19..94 /region_name="GST_N_GTT2_like" /note="GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; cd03051" /db_xref="CDD:239349" Site order(29,31..32,34..35,38..39,87,90..91) /site_type="other" /note="putative C-terminal domain interface [polypeptide binding]" /db_xref="CDD:239349" Site order(29,71..73,85..86) /site_type="other" /note="putative GSH binding site (G-site) [chemical binding]" /db_xref="CDD:239349" Site order(71,84..85,87..88,91) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:239349" Region 106..222 /region_name="GST_C_GTT2_like" /note="C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; cd03182" /db_xref="CDD:198291" Site order(114,121,183,186..187,190,194) /site_type="other" /note="putative N-terminal domain interface [polypeptide binding]" /db_xref="CDD:198291" Site order(114..115,118..119,122,165) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:198291" Site order(121,125..126,129..130,191,194) /site_type="other" /note="putative substrate binding pocket (H-site) [chemical binding]" /db_xref="CDD:198291" CDS 1..233 /gene="GTT2" /locus_tag="YLL060C" /coded_by="NM_001181880.1:1..702" /experiment="EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:9792709]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006749 glutathione metabolic process [PMID:9792709]" /note="Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850666" /db_xref="SGD:S000003983" ORIGIN 1 mngrgfliyn ggekmkqkmi iydtpagpyp arvrialaek nmlssvqfvr inlwkgehkk 61 peflaknysg tvpvlelddg tliaectait eyidaldgtp tltgktplek gvihmmnkra 121 elelldpvsv yfhhatpglg pevelyqnke wglrqrdkal hgmhyfdtvl rerpyvagds 181 fsmaditvia glifaaivkl qvpeecealr awykrmqqrp svkklleirs kss // LOCUS NP_013042 575 aa linear PLN 30-JUN-2025 DEFINITION cystathionine gamma-synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013042 VERSION NP_013042.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181878.1 REFERENCE 1 (residues 1 to 575) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 575) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 575) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 575) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09266. Method: conceptual translation. FEATURES Location/Qualifiers source 1..575 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..575 /product="cystathionine gamma-synthase" /EC_number="2.5.1.47" /EC_number="2.5.1.49" /calculated_mol_wt="64092" Region 213..565 /region_name="AAT_I" /note="Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl18945" /db_xref="CDD:450240" Site order(232..233,236,324,353,356,373,376) /site_type="other" /note="pyridoxal 5'-phosphate binding pocket [chemical binding]" /db_xref="CDD:99738" Site 376 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99738" CDS 1..575 /gene="HSU1" /locus_tag="YLL058W" /coded_by="NM_001181878.1:1..1728" /experiment="EXISTENCE:direct assay:GO:0051009 O-acetylhomoserine sulfhydrylase activity [PMID:36379252]" /experiment="EXISTENCE:mutant phenotype:GO:0006790 sulfur compound metabolic process [PMID:36379252]" /note="Inefficient homocysteine synthase; catalyzes de novo homocysteine biosynthesis; capable of catalyzing same reaction as Met17p; affects S-methylmethionine metabolism; similar to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; HSU1 is not an essential gene" /db_xref="GeneID:850668" /db_xref="SGD:S000003981" ORIGIN 1 mteiefgqpl psnldyavsf giptwdsaig yaekvpevig kmatgypryf pqppvqrlca 61 yfvkkfgrgs encrpfpsvn lglkcfeyvk svsgpeskah levetvtikn rgaktskepa 121 elvltiaavl aseeefetvk eywklrgecv ssrlalsvnq lldcanhgse qvlreleagv 181 faakkgeeka knlikgrive nrfrpfglek ktpnweglnl npnedvylvs sgmsaistar 241 nlltfweekk nsgdslnktt sdqkkkpllc dtvgifgfpf kdtqvimtkf gkckffgfgn 301 srdvvelqkf letskqrila vfvetpsnpl lnmpdlkklr sladqygffi viddtiggln 361 vdilpyadiv stsltklfng asnvmggsvv lnpksslypy areyfrsanf edllwcedai 421 vlernsrdfe drtlranant gillndlllp eegkickkiy yptvtsketf enyesvrner 481 ggygclfsva ffnegdakaf ydslkvfkgp sngtnftlac pyvhlahhse leevskfgad 541 pniirvsvgl ediqwllkvf ssaldvvksr gskhs // LOCUS NP_013043 412 aa linear PLN 30-JUN-2025 DEFINITION sulfonate dioxygenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013043 VERSION NP_013043.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181877.1 REFERENCE 1 (residues 1 to 412) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 412) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 412) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 412) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09267. Method: conceptual translation. FEATURES Location/Qualifiers source 1..412 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..412 /product="sulfonate dioxygenase" /calculated_mol_wt="46852" Region 112..391 /region_name="TauD" /note="Taurine dioxygenase, alpha-ketoglutarate-dependent [Secondary metabolites biosynthesis, transport and catabolism]; COG2175" /db_xref="CDD:441778" CDS 1..412 /gene="JLP1" /locus_tag="YLL057C" /coded_by="NM_001181877.1:1..1239" /experiment="EXISTENCE:direct assay:GO:0000907 sulfonate dioxygenase activity [PMID:10482536]" /experiment="EXISTENCE:mutant phenotype:GO:0044273 sulfur compound catabolic process [PMID:10482536]" /note="Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase; involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation" /db_xref="GeneID:850669" /db_xref="SGD:S000003980" ORIGIN 1 mspaaaqtai plpstdlpvk iitnglknln ytskqgygnf dthfydgqde vspsgllkir 61 ksyrekskyp dylptwdpte kygplefhey hdpalradgn fsnlfakenv gqlkvkkitp 121 klgleingiq ltdlsdaakd elallvaqkg vvvfrnqnfa degpdyvtey grhfgklhih 181 qtsghpqnnp elhitfrrpd aeefarvfdd stssggwhtd vsyelqppsy tffsvvegpd 241 gggdtlfadt ieafdrlskp lqdflstlhv ihsskeqaen sqrqggikrr apvthihplv 301 rvhpvlkkkc lyvnrafsrk ivelkrqese sllnflynlv esshdlqlra kwephsvviw 361 dnrrvqhsav idweepihrh afritpqaer pvedlkflnd enyypssltl di // LOCUS NP_013044 298 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLL056C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013044 VERSION NP_013044.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181876.1 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09268. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..298 /product="uncharacterized protein" /calculated_mol_wt="32017" Region 1..291 /region_name="SDR_a7" /note="atypical (a) SDRs, subgroup 7; cd05262" /db_xref="CDD:187572" Site order(7,9..12,31..33,73..75,88,110..112,132,136,159..162) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:187572" CDS 1..298 /locus_tag="YLL056C" /coded_by="NM_001181876.1:1..897" /experiment="EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:28265724]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:28265724]" /note="NADH-dependent aldehyde reductase; reduces many aldehyde compounds including glycolaldehyde, formaldehyde and furfural; transcription unregulated by furfural, 5-hydroxymethylfurfural (HMF) and the mycotoxin patulin; expression increased by multidrug resistance transcription factors Yrm1p and Yrr1p; member of atypical subgroup 7 of the short-chain dehydrogenase/reductase (SDR) family; localizes to the cytoplasm; SWAT-GFP and mCherry fusion proteins localize to the ER and vacuole respectively" /db_xref="GeneID:850670" /db_xref="SGD:S000003979" ORIGIN 1 mkvfitgasg figsavlsel issghevvgl arsdeaaaki ksidpaakil rgdlkdleil 61 kkgatesdgv ihlgfvhdfk nfeqcceidr qatvamlesl kgsnkpflyt ngtlslrpnk 121 vaneqdgide dskilravte qvalsykdkg vsarivrlpf svhgkgdkaf vpilmniaka 181 agksgyvgqg tnawaavhrl dtaplfrlvl ekgktgqvyh cvgeqgipfk diarvigeil 241 nvpvasipvd daeshfgflt cfvtrdgpvs segtrkelgw qpqqiglled iranysln // LOCUS NP_013045 531 aa linear PLN 30-JUN-2025 DEFINITION Yct1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013045 VERSION NP_013045.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181875.1 REFERENCE 1 (residues 1 to 531) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 531) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 531) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 531) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 531) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 531) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 531) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 531) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 531) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09269. Method: conceptual translation. FEATURES Location/Qualifiers source 1..531 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..531 /product="Yct1p" /calculated_mol_wt="58774" Region 54..462 /region_name="MFS_FEN2_like" /note="Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; cd17327" /db_xref="CDD:340885" Site order(70..71,74..75,78,111,161..162,164..166,169,189, 192..193,196,295,298..299,302..304,307,334,338,391..392, 396,400,417,420..421,424..425,428) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340885" CDS 1..531 /gene="YCT1" /locus_tag="YLL055W" /coded_by="NM_001181875.1:1..1596" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0033229 cysteine transmembrane transporter activity [PMID:17435223]" /experiment="EXISTENCE:direct assay:GO:0042883 cysteine transport [PMID:17435223]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0033229 cysteine transmembrane transporter activity [PMID:17435223]" /experiment="EXISTENCE:mutant phenotype:GO:0042883 cysteine transport [PMID:17435223]" /note="High-affinity cysteine-specific transporter; has similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene" /db_xref="GeneID:850671" /db_xref="SGD:S000003978" ORIGIN 1 mskvdvkiga dsisssdeil vpsrladvtl afmeendaav peitpeqekk lkrklfltif 61 tfvsainlll ymdkatlsyd silgffedtg ltqntyntvn tlfyvgfaig qfpgqylaqk 121 lplgkflggl latwtilifl sctaynfsgv valrfflglt esvvipilit tmgmffdase 181 raaaqpfffa acmgspiptg fiaygvlhit npsislwkif tiiiggltfi mtvvvilwfp 241 nnpadvkffs iqervwiirr vqastgssie qkvfkksqfr eamkdyitwl fglffllqql 301 annlpyqqnl lfegmggvda lgstlvsvag agfavvcafi atlmlakwkn isaltaifwt 361 lpalvgsiaa aalpwdnkig ilanicmagq ifgipfiial swasssasgy tkkltrssvs 421 lfamgianii spqiwrekds prflpawivq ivlsfslapa illlihfilk rrnnqrlkny 481 denlqnyldr iqliesenps sieegkvvth ennlavfdlt dlenetfiyp l // LOCUS NP_013046 843 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLL054C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013046 VERSION NP_013046.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181874.2 REFERENCE 1 (residues 1 to 843) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 843) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 843) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 843) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09270. On Apr 26, 2011 this sequence version replaced NP_013046.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..843 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..843 /product="uncharacterized protein" /calculated_mol_wt="97480" Region 9..50 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(10,14,19..22,24,27,37) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(15,18,25,32,35,42) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 231..687 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..843 /locus_tag="YLL054C" /coded_by="NM_001181874.2:1..2532" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="hypothetical protein with similarity to Pip2p; an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene" /db_xref="GeneID:850672" /db_xref="SGD:S000003977" ORIGIN 1 msiasqkkvk psfvclrckq rkikcdklwp tcskckasss icsyevepgr inksptiena 61 phrdirnitp asmsasgsft silnpstkdw emknfamnls nahdklvvmn nttivdspfa 121 fhsilqhdly akalttcihe rilidverhr envsannkkr elnltigdig plffidkaal 181 kfientskts klyppidfly ntydyeqahp eenndkisin illeelskyf lnknevdgli 241 vdfyktiypv yplleislfe dnirellqln efngynivfa gkdsrrklet itlltiilaf 301 syrrlslsts hsfkesfgvk snnltllahk llalmnvfqy vnehtlccll yffilrylnp 361 dqadmypths dilnlkflen vaiklglnee pfqytryvse sddyprlfnl rrklwlgvqf 421 lkfgilipeg dsdilsleyl rsfmktdesl pelfernyas tnnldlslma taeniyhlhl 481 slqvlltscf pingpsylke vldnidktkd flnqkfplil sslgeprmks lhinvpssla 541 neesfdfstf eenetfianv isytctmniy dslslhfenq cfknaleykt yyhrftftai 601 qdyltllkli seyfngsllh lrepfgfatq kvvrfsihrl lifqatllvr lfykkdtcdr 661 ssaamgmlnd rngrlsrvie kmiklmsyhm kllveivisk leksylgsfi svsifryiiy 721 lvdtdalsaf isdywksdav mderysrihr ivglkwgmgr dksfsftskl nnpqflgsld 781 leileelekl isaqefsrnf tedvdeslqs eidlmnydne alnqlmaidl dkllgifpnl 841 snf // LOCUS NP_013047 152 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLL053C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013047 VERSION NP_013047.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181873.1 REFERENCE 1 (residues 1 to 152) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 152) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 152) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 152) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09271. Method: conceptual translation. FEATURES Location/Qualifiers source 1..152 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..152 /product="uncharacterized protein" /calculated_mol_wt="16325" Region <20..128 /region_name="MIP" /note="Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; cl00200" /db_xref="CDD:444743" CDS 1..152 /locus_tag="YLL053C" /coded_by="NM_001181873.1:1..459" /note="Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin" /db_xref="GeneID:850673" /db_xref="SGD:S000003976" ORIGIN 1 mwfpqiiagm aaggaasamt pgkvlftnal glgcsrsrgl flemfgtavl cltvlmtave 61 kretnfmaal pigislfmah maltgytgtg vnparslgaa vaaryfphyh wiywispllg 121 aflawsvwql lqildyttyv naekaagqkk ed // LOCUS NP_013048 149 aa linear PLN 30-JUN-2025 DEFINITION Aqy2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013048 VERSION NP_013048.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181872.1 REFERENCE 1 (residues 1 to 149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 149) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09272. Method: conceptual translation. FEATURES Location/Qualifiers source 1..149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..149 /product="Aqy2p" /calculated_mol_wt="16893" Region 53..>109 /region_name="MIP" /note="Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; cl00200" /db_xref="CDD:444743" CDS 1..149 /gene="AQY2" /locus_tag="YLL052C" /coded_by="NM_001181872.1:1..450" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11168368]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11168368]" /experiment="EXISTENCE:direct assay:GO:0006833 water transport [PMID:11158584]" /experiment="EXISTENCE:direct assay:GO:0015250 water channel activity [PMID:11158584]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:11158584]" /experiment="EXISTENCE:genetic interaction:GO:0055085 transmembrane transport [PMID:11158584]" /note="Water channel that mediates water transport across cell membranes; only expressed in proliferating cells; controlled by osmotic signals; may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains" /db_xref="GeneID:850674" /db_xref="SGD:S000003975" ORIGIN 1 msnesndlek nishldptgv dnayippeqp etkhsrfnid rdtlrnhfia avgefcgtfm 61 flwcayvicn vanhdvaltt epegshpgql imialgfgfs vmfsiwcfww gfepsrfslf 121 vfgqshltsq mcsdvvssdh cwdgcwwcr // LOCUS NP_013049 712 aa linear PLN 30-JUN-2025 DEFINITION putative ferric-chelate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013049 VERSION NP_013049.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181871.1 REFERENCE 1 (residues 1 to 712) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 712) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 712) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 712) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09273. Method: conceptual translation. FEATURES Location/Qualifiers source 1..712 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..712 /product="putative ferric-chelate reductase" /EC_number="1.16.1.9" /calculated_mol_wt="81858" Region 287..404 /region_name="Ferric_reduct" /note="Ferric reductase like transmembrane component; pfam01794" /db_xref="CDD:426438" Region 438..544 /region_name="FAD_binding_8" /note="FAD-binding domain; pfam08022" /db_xref="CDD:285293" Site order(478,493..496,507..509,513..516) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(493,495..496) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99783" Region 564..691 /region_name="NAD_binding_6" /note="Ferric reductase NAD binding domain; pfam08030" /db_xref="CDD:429792" Site order(585..586,589) /site_type="other" /note="NADP ribose binding motif [chemical binding]" /db_xref="CDD:99783" CDS 1..712 /gene="FRE6" /locus_tag="YLL051C" /coded_by="NM_001181871.1:1..2139" /experiment="EXISTENCE:direct assay:GO:0000293 ferric-chelate reductase activity [PMID:17681937]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:17681937|PMID:17553781]" /experiment="EXISTENCE:genetic interaction:GO:0015677 copper ion import [PMID:17553781]" /experiment="EXISTENCE:mutant phenotype:GO:0000293 ferric-chelate reductase activity [PMID:17681937]" /note="Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:850675" /db_xref="SGD:S000003974" ORIGIN 1 mhrtllfltw lisltkafni klphtekkdh lesnavlaca syintlkwsf dssvvpgfys 61 ticsyspafd twslcifnsl tdqiipmdnt sfeeslgnvr ktcsfvdkkf snisleqyys 121 slnnasshal edygsiesls tsirvdretr srwirafhah aynldissvy gayltyyfvi 181 vgiiavffhm shynglnral fasrfvnyir ghfvlptflv dkhanhfkfl nvevftglmp 241 nsleawiifg ytlaniifls isyiidpynl ifnshlsqft rlladrsgil aftqfpliii 301 ftarnsflef ltgvkfnsfi sfhkwigrim vlnatihsls yslfaiinha fkisnkqlyw 361 kfgiasitvl cvllvlslgi vrkrhyeffl ythiilallf fyccwqhvki fngwkewivv 421 slliwglekl friwnilqfr fpkatlinln tsnnphdemf kviipkynrr whskpgqycf 481 iyflhplvfw qchpftiide gekcvlvikp ksgltrfiyn hilqslngkl qlrvaiegpy 541 gpsnlhldkf dhllllsggt glpgpldhai klsrnpdkpk sidlimaikn psflngykse 601 ilelknsrsh vnvqvyltqk tavtkaanar dqlihfddim teltsfahig narpnfsnvi 661 enaikstppg dslavvccgp pvlvddvrnt vsqkllgype riieyfeeyq cw // LOCUS NP_013050 143 aa linear PLN 30-JUN-2025 DEFINITION cofilin [Saccharomyces cerevisiae S288C]. ACCESSION NP_013050 VERSION NP_013050.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181870.1 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09274. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..143 /product="cofilin" /calculated_mol_wt="15770" Region 4..136 /region_name="ADF_cofilin_like" /note="Cofilin, Destrin, and related actin depolymerizing factors; cd11286" /db_xref="CDD:200442" Site 4..5 /site_type="other" /note="putative G-actin interface [polypeptide binding]" /db_xref="CDD:200442" Site order(80,82,96,123,126) /site_type="other" /note="putative F-actin interface [polypeptide binding]" /db_xref="CDD:200442" CDS 1..143 /gene="COF1" /locus_tag="YLL050C" /coded_by="NM_001181870.1:1..432" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0007015 actin filament organization [PMID:16569665]" /experiment="EXISTENCE:direct assay:GO:0030042 actin filament depolymerization [PMID:8421056|PMID:16569665|PMID:8440472]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:8163554|PMID:8421056]" /experiment="EXISTENCE:direct assay:GO:0051014 actin filament severing [PMID:14680631|PMID:8421056]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:16569665|PMID:8421056|PMID:8440472]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:22553351]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:17875745|PMID:16569665]" /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:22553351]" /note="Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes" /db_xref="GeneID:850676" /db_xref="SGD:S000003973" ORIGIN 1 msrsgvavad esltafndlk lgkkykfilf glndakteiv vketstdpsy dafleklpen 61 dclyaiydfe yeingnegkr skivfftwsp dtapvrskmv yasskdalrr alngvstdvq 121 gtdfsevsyd svlervsrga gsh // LOCUS NP_013051 179 aa linear PLN 30-JUN-2025 DEFINITION Ldb18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013051 VERSION NP_013051.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181869.1 REFERENCE 1 (residues 1 to 179) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 179) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 179) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 179) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09275. Method: conceptual translation. FEATURES Location/Qualifiers source 1..179 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..179 /product="Ldb18p" /calculated_mol_wt="20716" CDS 1..179 /gene="LDB18" /locus_tag="YLL049W" /coded_by="NM_001181869.1:1..540" /experiment="EXISTENCE:direct assay:GO:0005869 dynactin complex [PMID:18245366]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:18245366]" /note="Component of the dynactin complex; dynactin is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24" /db_xref="GeneID:850677" /db_xref="SGD:S000003972" ORIGIN 1 mpglklveal eyrcdrlerl igagysansd vsvqldelyn qlhrlyfqgl kysqdllqlf 61 ntfmaedien vgapddicif ascfddiytl ysafdelnsq ymefcqisks sldqisfkda 121 nietkqlkkl pelvdncnim ilrsiailnr fidwnievng ffqfqkkrll nlqkviyst // LOCUS NP_013052 1661 aa linear PLN 30-JUN-2025 DEFINITION bile acid-transporting ATPase YBT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013052 VERSION NP_013052.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181868.1 REFERENCE 1 (residues 1 to 1661) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1661) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1661) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1661) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09276. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1661 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1661 /product="bile acid-transporting ATPase YBT1" /calculated_mol_wt="189032" Region <353..1639 /region_name="MRP_assoc_pro" /note="multi drug resistance-associated protein (MRP); TIGR00957" /db_xref="CDD:188098" CDS 1..1661 /gene="YBT1" /locus_tag="YLL048C" /gene_synonym="BAT1" /coded_by="NM_001181868.1:1..4986" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:9182565]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:mutant phenotype:GO:0015718 monocarboxylic acid transport [PMID:9182565]" /experiment="EXISTENCE:mutant phenotype:GO:0033285 ATPase-coupled monocarboxylic acid transmembrane transporter activity [PMID:9182565]" /note="Transporter of ATP-binding cassette (ABC) family; targeted to vacuole via AP-3 pathway; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication" /db_xref="GeneID:850678" /db_xref="SGD:S000003971" ORIGIN 1 mhhvlnstrp dhrfwfyddv tqygrtkyln yytplvllif tvlfityniw khyyyydvlh 61 lkqknpidel lysstdedeq splinnntit tnyvdnnctk dalknrhfsl eklksvkvng 121 ephgtpeivr rgfieksrii lefflvlsqv iihsfillhy vnknpeftqq gtitglvewc 181 alfiivslrl anvnqnfkfi nkypgnlwsv sfinylalfi smilpfrsif ihhinspisr 241 kyyisqisin lalflllffa rirnnfaiiy ktdswitpsp epvtsiagfi cwawldsfvw 301 kahkvsikvk diwglmmqdy sffvvkkfry fvdhkvkrkr ifslnlffff snylvlqcfw 361 aflgsvlsfi ptvllkrile yvedqssaps nlawfyvtvm fvgrilvaic qaqalffgrr 421 vcirmksiii seiytkalrr kistnktkps nedpqeindq ksingdeest ssanlgaiin 481 lmaidafkvs eicgylhsfl eafvmtvval allyrllgfa aivgvliiva mlplnyklak 541 yigdlqkknl avtdnriqkl neafqairii kyfsweenfe kdintirene lslllmrsiv 601 wsissflwfv tptivtaasf ayyiyvqgev lttpvaftal slftllrdpl drlsdmlsfv 661 vqskvsldrv qdflnendtk kydqltidpn gnrfafenst iswdkdnqdf klkdlniefk 721 tgklnvvigp tgsgktsllm allgemylln gkvvvpalep rqelivdang ttnsiaycsq 781 aawllndtvk nnilfnspfn earykavvea cglkrdfeil kagdlteige kgitlsggqk 841 qrvslaraly snarhvlldd clsavdshta swiydncitg plmedrtcil vshnialtlr 901 naelvvlled grvkdqgdpi dmlqkglfge delvkssils ranssanlaa ksstslsnlp 961 avkeqqvsvn nnsshfeakk lqkslrteae rtedgklike etkeegvvgl dvykwylkif 1021 ggwkivsfla slfliaqlly igqswwvraw ashnviakii praqraiafi skkashlidw 1081 rgssqismas aenqpssghs tmyylvlyli igfaqallga gktilnfvag inasrkifnm 1141 ilnkvlhski rffdatptgr imnrfskdie aidqeltpyi qgafysliec lstvilitfi 1201 tpqflsvaiv vsilyyfvgy fymagsrelk rfesisrspi yqhfsetlvg vttirafgde 1261 grfmqenlhk idennkpffy lwvanrwlaf ridmigslvi fgaglfilfn innldsgmag 1321 isltyaisft egalwlvrly sevemnmnsv ervkeymeie qepynehkei pppqwpqdgk 1381 ievndlslry apnlprvikn vsfsvdaqsk igivgrtgag kstiitalfr flepetghik 1441 idnidisgvd lqrlrrsiti ipqdptlfsg tiktnldpyd efsdrqifea lkrvnlisee 1501 qlqqgatret sneasstnse nvnkfldlss eiseggsnls qgqrqlmcla rsllrspkii 1561 lldeatasid yssdakiqet irkefqgsti ltiahrlrsv idydkilvmd agevkeydhp 1621 yslllnkqsa fysmcehsge ldilielakk afveklnskk d // LOCUS NP_013054 249 aa linear PLN 30-JUN-2025 DEFINITION Rnp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013054 VERSION NP_013054.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181866.1 REFERENCE 1 (residues 1 to 249) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 249) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 249) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 249) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09277. Method: conceptual translation. FEATURES Location/Qualifiers source 1..249 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..249 /product="Rnp1p" /calculated_mol_wt="28731" Region 36..109 /region_name="RRM" /note="RNA recognition motif; smart00360" /db_xref="CDD:214636" Region <37..>238 /region_name="PABP-1234" /note="polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628" /db_xref="CDD:130689" CDS 1..249 /gene="RNP1" /locus_tag="YLL046C" /coded_by="NM_001181866.1:1..750" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8341595]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:8341595]" /note="Ribonucleoprotein that contains two RNA recognition motifs (RRM); RNP1 has a paralog, SBP1, that arose from the whole genome duplication" /db_xref="GeneID:850680" /db_xref="SGD:S000003969" ORIGIN 1 mlieeiefyn vngkktttvv pentkikkrv lndrrtlyvg nlpkncrkqd lrdlfepnyg 61 kitinmlkkk plkkplkrfa fiefqegvnl kkvkekmngk ifmnekivie niltkeeksf 121 eknqksnkkt apdlkplstn tlyvknipmk stnedlakif gvdpkninfv rrelvdlrtn 181 kvffsdefht geafikfdnl gtgdsiqkkc refkgrkasn grvllvkias akkneqkqeg 241 gdntkikqn // LOCUS NP_013055 256 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL8 RPL8B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013055 VERSION NP_013055.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181865.1 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09278. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..256 /product="60S ribosomal protein eL8 RPL8B" /calculated_mol_wt="27981" Region 2..251 /region_name="SNU13" /note="U4/U6.U5 small nuclear ribonucleoprotein SNU13; cl42391" /db_xref="CDD:455736" Site order(137,140..141,144,159,161..162,164..165,168) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:411046" CDS 1..256 /gene="RPL8B" /locus_tag="YLL045C" /gene_synonym="KRB1; SCL41" /coded_by="NM_001181865.1:1..771" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22893726]" /note="Ribosomal 60S subunit protein L8A; required for processing of 27SA3 pre-rRNA to 27SB during assembly of large subunit; binds Domain I of 25S, 5.8 S rRNAs; mutation results in decreased amounts of free 60S subunits; RPL8B has paralog RPL8A from whole genome duplication; RPL8A or RPL8B ribosomes not functionally interchangeable; proportions of Rpl8ap, Rpl8bp in 80S ribosome differ in glucose and glycerol; homologous to mammalian ribosomal protein L7A, no bacterial homolog" /db_xref="GeneID:850682" /db_xref="SGD:S000003968" ORIGIN 1 mapgkkvapa pfgakstksn kaknplthst pknfgigqav qpkrnlsryv kwpeyvrlqr 61 qkkilsirlk vpptiaqfqy tldrntaaet fklfnkyrpe taaekkerlt keaaaiaegk 121 skqdaspkpy avkyglnhvv slienkkakl vliandvdpi elvvflpalc kkmgvpyaii 181 kgkarlgtlv nqktsavaal tevraedeaa laklvstida nfadkydevk khwgggilgn 241 kaqakmdkra ktsdsa // LOCUS NP_013057 669 aa linear PLN 30-JUN-2025 DEFINITION Fps1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013057 VERSION NP_013057.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181863.1 REFERENCE 1 (residues 1 to 669) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 669) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 669) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 669) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09279. Method: conceptual translation. FEATURES Location/Qualifiers source 1..669 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..669 /product="Fps1p" /calculated_mol_wt="73747" Region 244..527 /region_name="MIP" /note="Major intrinsic protein; pfam00230" /db_xref="CDD:395174" Site order(330,350..352,476..477,480,483) /site_type="active" /note="amphipathic channel [active]" /db_xref="CDD:238204" Site order(352..354,480..482) /site_type="other" /note="Asn-Pro-Ala signature motifs" /db_xref="CDD:238204" CDS 1..669 /gene="FPS1" /locus_tag="YLL043W" /coded_by="NM_001181863.1:1..2010" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11914276|PMID:20026328]" /experiment="EXISTENCE:direct assay:GO:0015168 glycerol transmembrane transporter activity [PMID:8550015|PMID:7729414|PMID:12486125]" /experiment="EXISTENCE:direct assay:GO:0015793 glycerol transmembrane transport [PMID:12486125]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:9281576]" /experiment="EXISTENCE:mutant phenotype:GO:0006846 acetate transport [PMID:17620418]" /experiment="EXISTENCE:mutant phenotype:GO:0015168 glycerol transmembrane transporter activity [PMID:7729414|PMID:8550015]" /experiment="EXISTENCE:mutant phenotype:GO:0015254 glycerol channel activity [PMID:22593571]" /experiment="EXISTENCE:mutant phenotype:GO:0015700 arsenite transport [PMID:20026328]" /experiment="EXISTENCE:mutant phenotype:GO:0015791 polyol transmembrane transport [PMID:23475614]" /experiment="EXISTENCE:mutant phenotype:GO:0015793 glycerol transmembrane transport [PMID:23475614|PMID:22593571]" /note="Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in transport of acetate, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p and Slt2p MAPK; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state" /db_xref="GeneID:850683" /db_xref="SGD:S000003966" ORIGIN 1 msnpqkalnd flssesvhth dssrkqsnkq ssdegrsssq pshhhsggtn nnnnnnnnnn 61 nsnnnnngnd ggndddydye mqdyrpspqs arptptyvpq ysvesgtafp iqevipsayi 121 ntqdinhkdn gppsassnra frprgqttvs anvlniedfy knaddahtip eshlsrrrsr 181 sratsnaghs antgatngrt tgaqtnmesn esprnvpimv kpktlyqnpq tptvlpstyh 241 pinkwssvkn tylkeflaef mgtmvmiifg savvcqvnva gkiqqdnfnv aldnlnvtgs 301 saetidamks ltslvssvag gtfddvalgw aaavvmgyfc aggsaisgah lnpsitlanl 361 vyrgfplkkv pyyfagqlig aftgalilfi wykrvlqeay sdwwmnesva gmfcvfpkpy 421 lssgrqffse flcgamlqag tfaltdpytc lssdvfplmm filifiinas mayqtgtamn 481 lardlgprla lyavgfdhkm lwvhhhhffw vpmvgpfiga lmgglvydvc iyqghespvn 541 wslpvykemi mrawfrrpgw kkrnrarrts dlsdfsynnd ddeefgerma lqktktkssi 601 sdneneagek kvqfksvqrg krtfggipti leeedsieta slgatttdsi glsdtsseds 661 hygnakkvt // LOCUS NP_013058 167 aa linear PLN 30-JUN-2025 DEFINITION E2-like conjugating enzyme [Saccharomyces cerevisiae S288C]. ACCESSION NP_013058 VERSION NP_013058.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181862.1 REFERENCE 1 (residues 1 to 167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 167) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09280. Method: conceptual translation. FEATURES Location/Qualifiers source 1..167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..167 /product="E2-like conjugating enzyme" /calculated_mol_wt="19629" Region <62..157 /region_name="Autophagy_act_C" /note="Autophagocytosis associated protein, active-site domain; pfam03987" /db_xref="CDD:461120" CDS 1..167 /gene="ATG10" /locus_tag="YLL042C" /gene_synonym="APG10" /coded_by="NM_001181862.1:1..504" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:10508157]" /experiment="EXISTENCE:mutant phenotype:GO:0019777 Atg12 transferase activity [PMID:10508157]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:10508157]" /experiment="EXISTENCE:mutant phenotype:GO:0032446 protein modification by small protein conjugation [PMID:9759731|PMID:10508157]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:physical interaction:GO:0032446 protein modification by small protein conjugation [PMID:10508157]" /note="Conserved E2-like conjugating enzyme; mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy" /db_xref="GeneID:850684" /db_xref="SGD:S000003965" ORIGIN 1 mipyqewhsq lqslydsqif hnwalcqdvh lndekdglll rliptrqlqk nterienkll 61 nhielyltys kvynepllll riweeksidg ipmtklmlpt dieslldvqg kfqlgldtii 121 nlegsvwysf hpcdtscivg dqaefmstyl rrwvsififs wlgyeds // LOCUS NP_013059 266 aa linear PLN 30-JUN-2025 DEFINITION succinate dehydrogenase iron-sulfur protein subunit SDH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013059 VERSION NP_013059.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181861.1 REFERENCE 1 (residues 1 to 266) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 266) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 266) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 266) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09281. Method: conceptual translation. FEATURES Location/Qualifiers source 1..266 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..266 /product="succinate dehydrogenase iron-sulfur protein subunit SDH2" /EC_number="1.3.5.1" /calculated_mol_wt="30100" Region 31..264 /region_name="PLN00129" /note="succinate dehydrogenase [ubiquinone] iron-sulfur subunit" /db_xref="CDD:215067" CDS 1..266 /gene="SDH2" /locus_tag="YLL041C" /gene_synonym="ACN17" /coded_by="NM_001181861.1:1..801" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:13445213]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:1939170]" /experiment="EXISTENCE:direct assay:GO:0045273 respiratory chain complex II (succinate dehydrogenase) [PMID:9822678]" /experiment="EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:16232921]" /experiment="EXISTENCE:genetic interaction:GO:0045333 cellular respiration [PMID:16232921]" /experiment="EXISTENCE:mutant phenotype:GO:0006099 tricarboxylic acid cycle [PMID:10224250]" /experiment="EXISTENCE:mutant phenotype:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:16232921]" /experiment="EXISTENCE:mutant phenotype:GO:0045333 cellular respiration [PMID:16232921]" /note="Iron-sulfur protein subunit of succinate dehydrogenase; the complex couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain; other members are Sdh1p, Sdh3p, and Sdh4p" /db_xref="GeneID:850685" /db_xref="SGD:S000003964" ORIGIN 1 mlnvllrrka fclvtkkgma tattaaatht prlktfkvyr wnpdepsakp hlqsyqvdln 61 dcgpmvldal lkikdeqdst ltfrrscreg icgscamnig grntlacick idqneskqlk 121 iyplphmfiv kdlvpdltnf yqqyksiqpy lqrssfpkdg tevlqsiedr kkldglyeci 181 lcaccstscp sywwnqeqyl gpavlmqayr wlidsrdqat ktrkamlnns mslyrchtim 241 nctrtcpkgl npglaiaeik kslafa // LOCUS NP_013060 3144 aa linear PLN 30-JUN-2025 DEFINITION membrane morphogenesis protein VPS13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013060 VERSION NP_013060.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181860.1 REFERENCE 1 (residues 1 to 3144) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 3144) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 3144) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 3144) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 3144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 3144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 3144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 3144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 3144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09282. Method: conceptual translation. FEATURES Location/Qualifiers source 1..3144 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..3144 /product="membrane morphogenesis protein VPS13" /calculated_mol_wt="357720" Region 1..2294 /region_name="MRS6" /note="Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]; COG5043" /db_xref="CDD:227376" Region <2356..3144 /region_name="MRS6" /note="Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]; COG5043" /db_xref="CDD:227376" CDS 1..3144 /gene="VPS13" /locus_tag="YLL040C" /gene_synonym="SOI1; VPT2; YME3" /coded_by="NM_001181860.1:1..9435" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:28122955]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:22442115|PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:32690699]" /experiment="EXISTENCE:direct assay:GO:0006895 Golgi to endosome transport [PMID:28122955]" /experiment="EXISTENCE:direct assay:GO:0044232 organelle membrane contact site [PMID:27280386]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:26370498]" /experiment="EXISTENCE:direct assay:GO:0090083 regulation of inclusion body assembly [PMID:31433985]" /experiment="EXISTENCE:direct assay:GO:0120009 intermembrane lipid transfer [PMID:30093493]" /experiment="EXISTENCE:direct assay:GO:0120014 phospholipid transfer activity [PMID:30093493]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:26370498]" /experiment="EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:26370498]" /experiment="EXISTENCE:genetic interaction:GO:0036258 multivesicular body assembly [PMID:40047640]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8887651]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:32690699]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:22442115|PMID:26605945]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:9314526]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:9265642]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:32690699]" /note="Lipid transport protein; involved in vacuolar protein sorting, protein retention in the Golgi, and prospore membrane formation; required for mitochondrial integrity and ER packaging into autophagosomes during cortical reticulophagy; role in membrane remodeling for MVB biogenesis with phospholipid scramblase Any1p; peripheral membrane protein of the prospore membrane and membrane contact sites; homolog of human VPS13A and VPS13B, involved in Chorea-acanthocytosis and Cohen syndrome, respectively" /db_xref="GeneID:850619" /db_xref="SGD:S000003963" ORIGIN 1 mleslaanll nrllgsyven fdpnqlnvgi wsgdvklknl klrkdcldsl nlpidvksgi 61 lgdlvltvpw sslknkpvki iiedcyllcs prsedhende emikrafrlk mrkvsewelt 121 nqarilstqs enktssssse knnagfmqsl ttkiidnlqv tiknihlrye dmdgifttgp 181 ssvgltlnel savstdsnwa psfiditqni thklltlnsl clywntdspp lisdddqdrs 241 lenfvrgfkd miasknstap khqyilkpvs glgklsinkl gsteeqphid lqmfydefgl 301 elddteyndi lhvlssiqlr qitkkfkkar psfavsenpt ewfkyiaacv ineiheknkm 361 wtwesmkekc eqrrlytklw veklklknle aplrdpiqea qlselhkdlt ydeiilfrsv 421 akrqyaqykl gmtedsptpt assniepqts nksatknngs wlsswwngkp teevdedlim 481 teeqrqelyd aiefdenedk gpvlqvprer velrvtsllk kgsftirkkk qnlnlgsiif 541 enckvdfaqr pdsflssfql nkfsledgsp nalykhiisv rnsskdqssi dnhatgeeee 601 edepllrasf elnpldglad snlnikllgm tvfyhvhfit evhkffkasn qhmetigniv 661 naaeatvegw ttqtrmgies lledhktvnv sldlqaplii lpldphdwdt pcaiidaghm 721 silsdlvpke kikeikelsp eeydkidgne inrlmfdrfq ilsqdtqifv gpdiqstigk 781 intasstndf rildkmklel tvdlsilpka yklptirvfg hlprlslsin diqyktimnl 841 iansipsmid deenngdyvn yssgsekemk kqiqlqlknt lkalenmqpl qieqkflelh 901 fdidqakiaf fqcikndsrn seklvdilcq rlnfnfdkra kemnldlrvh sldvedyiel 961 tdnkefknli ssgvekvtrs qkdlftlkyk rvqrivphnd tlielfdqdi vmhmselqlv 1021 ltprsvltlm nyamltftdp napempadvl rhnkedrdda pqkinmkikm eavnvifndd 1081 siklatlvls ageftmvllp eryninlklg gleltdetne sfsrdsvfrk iiqmkgqelv 1141 elsyesfdpa tntkdydsfl kystgsmhvn fiesavnrmv nffakfqksk vsfdrarlaa 1201 ynqapsidav nnmkmdivik apiiqfpklv gtqennydtm rfylgeffie nkfsvidesh 1261 kinhiklgvr egqlssnlnf dgssqqlylv enigllfnid rdplpqddtp elkvtsnfes 1321 faldltenql tylleisnkv ssafnitden sgesggkgei kspspdpasl ssesertatp 1381 qslqgsnksn iknpeqkyld fsfkapkial tlynktkgvt slndcgltri mfqdigcslg 1441 lkndgtvdgq ahvaafried vrnikdnkht elipksknke yqfvanisrk nlevgrllni 1501 smtmdspkmi lamdylvslk effdaimsks hennlyypen tnqkpenkai vesvqeggdv 1561 tkiqysvnii etalilladp cdmnseaisf kigqflvtdq nimtvaannv giflfkmnss 1621 eeklrllddf sssltidkrn stpqtlmtni qlsvqpllmr islrdirlam lifkrvttll 1681 nkmtekedng eeeestdkiq fsheferkla vldpsilger srasqssdse sievptailk 1741 netfnadlgg lrfiligdvh empildmnvn eitasakdws tdfealasle tyvnifnysr 1801 sswepllemi pitfhlskgh semdpafsfd iltqriaeit lsarsiamls hipaslteel 1861 plasrvsqkp yqlvndteld fdvwiqdktt ednknevvll kantslpwef edwrsirekl 1921 didksknilg vcvsgqnykt imnidatteg enlhvlsppr nnvhnrivce arcdennvki 1981 itfrstlvie nttsteiell vdskdpnkps lkyaikphqs ksvpveyayd sdirirpase 2041 diydwsqqtl swksllsnqm sifcsskeds nqrfhfeiga kydereplak ifphmkivvs 2101 asmtienllp adinfsifdk reekrtdflk tgesmevhhi sldsfllmsv qplqdeasas 2161 kpsivntphk splnpedsls ltlsggqnll lkldyknidg trskviriys pyiimnstdr 2221 elyiqsslln iaqskillen ekrytipkmf sfdkeddksn rarirfkese wssklsfdai 2281 gqsfdasvri knkeqesnlg inisegkgky llskvieiap ryiisntldi pievcetgsm 2341 dvqqiesnit kplyrmrniv dkqlvlkflg gdsnwsqpff iknvgvtylk vlknsrhkll 2401 kieilldkat ifirikdggd rwpfsirnfs dhdfifyqrd prkvsdpykd dqsnesssrs 2461 fkpifyrips ksimpyawdf ptakekylvl esgtrtrevr laeigelppl rldkrskdkp 2521 apivglhvva dddmqalviv nykanvglyk lktasattts svsvnssvtd gfvqkdedek 2581 vntqivvsfk gvgislingr lqellyinmr gielrynesk ayqtfswkmk wmqidnqlfs 2641 gnysnilypt eipytekeie nhpvisgsis kvndslqavp yfkhvtlliq efsiqldedm 2701 lyammdfikf pgspwimdsr dykydeeiql pdvselktag diyfeifhiq ptvlhlsfir 2761 sdeispglae eteesfsssl yyvhmfamtl gnineapvkv nslfmdnvrv plpilmdhie 2821 rhyttqfvyq ihkilgsadc fgnpvglfnt issgvwdlfy epyqgymmnd rpqeigihla 2881 kgglsfakkt vfglsdsmsk ftgsmakgls vtqdlefqrv rrlqqrinkn nrnalansaq 2941 sfastlgsgl sgialdpyka mqkegaagfl kglgkgivgl ptktaigfld ltsnlsqgvk 3001 stttvldmqk gcrvrlpryv dhdqiikpyd lreaqgqywl ktvnggvfmn deylshvilp 3061 gkelavivsm qhiaevqmat qelmwstgyp siqgitlers glqiklksqs eyfipisdpe 3121 errslyrnia iavreynkyc eail // LOCUS NP_013061 381 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin [Saccharomyces cerevisiae S288C]. ACCESSION NP_013061 VERSION NP_013061.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181859.1 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09283. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..381 /product="ubiquitin" /calculated_mol_wt="42695" Region 1..76 /region_name="Ubl_ubiquitin" /note="ubiquitin-like (Ubl) domain found in ubiquitin; cd01803" /db_xref="CDD:340501" Site order(6..9,11,34..37,40,42,44,46..49,68..76) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:340501" Site order(8..12,31..35,40,42,44,46..49,68,70..76) /site_type="other" /note="E1 interaction site [polypeptide binding]" /db_xref="CDD:340501" Region 77..152 /region_name="Ubl_ubiquitin" /note="ubiquitin-like (Ubl) domain found in ubiquitin; cd01803" /db_xref="CDD:340501" Site order(82..85,87,110..113,116,118,120,122..125,144..152) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:340501" Site order(84..88,107..111,116,118,120,122..125,144,146..152) /site_type="other" /note="E1 interaction site [polypeptide binding]" /db_xref="CDD:340501" Region 153..228 /region_name="Ubl_ubiquitin" /note="ubiquitin-like (Ubl) domain found in ubiquitin; cd01803" /db_xref="CDD:340501" Site order(158..161,163,186..189,192,194,196,198..201,220..228) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:340501" Site order(160..164,183..187,192,194,196,198..201,220,222..228) /site_type="other" /note="E1 interaction site [polypeptide binding]" /db_xref="CDD:340501" Region 229..304 /region_name="Ubl_ubiquitin" /note="ubiquitin-like (Ubl) domain found in ubiquitin; cd01803" /db_xref="CDD:340501" Site order(234..237,239,262..265,268,270,272,274..277,296..304) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:340501" Site order(236..240,259..263,268,270,272,274..277,296,298..304) /site_type="other" /note="E1 interaction site [polypeptide binding]" /db_xref="CDD:340501" Region 305..380 /region_name="Ubl_ubiquitin" /note="ubiquitin-like (Ubl) domain found in ubiquitin; cd01803" /db_xref="CDD:340501" Site order(310..313,315,338..341,344,346,348,350..353,372..380) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:340501" Site order(312..316,335..339,344,346,348,350..353,372,374..380) /site_type="other" /note="E1 interaction site [polypeptide binding]" /db_xref="CDD:340501" CDS 1..381 /gene="UBI4" /locus_tag="YLL039C" /gene_synonym="SCD2; UB14" /coded_by="NM_001181859.1:1..1146" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:22375831]" /experiment="EXISTENCE:direct assay:GO:0031386 protein tag activity [PMID:3038523]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:8035826]" /note="Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via ubiquitin-26S proteasome system; essential for cellular stress response; encoded as polyubiquitin precursor comprised of 5 head-to-tail repeats; number of repeats is evolutionarily unstable within and between yeast species; protein abundance increases in response to DNA replication stress; implicated as modulator of replicative lifespan and meiotic recombination" /db_xref="GeneID:850620" /db_xref="SGD:S000003962" ORIGIN 1 mqifvktltg ktitlevess dtidnvkski qdkegippdq qrlifagkql edgrtlsdyn 61 iqkestlhlv lrlrggmqif vktltgktit levessdtid nvkskiqdke gippdqqrli 121 fagkqledgr tlsdyniqke stlhlvlrlr ggmqifvktl tgktitleve ssdtidnvks 181 kiqdkegipp dqqrlifagk qledgrtlsd yniqkestlh lvlrlrggmq ifvktltgkt 241 itlevessdt idnvkskiqd kegippdqqr lifagkqled grtlsdyniq kestlhlvlr 301 lrggmqifvk tltgktitle vessdtidnv kskiqdkegi ppdqqrlifa gkqledgrtl 361 sdyniqkest lhlvlrlrgg n // LOCUS NP_013062 247 aa linear PLN 30-JUN-2025 DEFINITION Ent4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013062 VERSION NP_013062.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181858.1 REFERENCE 1 (residues 1 to 247) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 247) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 247) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 247) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09284. Method: conceptual translation. FEATURES Location/Qualifiers source 1..247 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..247 /product="Ent4p" /calculated_mol_wt="28140" Region 15..132 /region_name="ENTH_Ent4" /note="Epsin N-Terminal Homology (ENTH) domain of Yeast Ent4 and similar proteins; cd16994" /db_xref="CDD:340791" Site order(20,24..25,59,71,75) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:340791" CDS 1..247 /gene="ENT4" /locus_tag="YLL038C" /coded_by="NM_001181858.1:1..744" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0072659 protein localization to plasma membrane [PMID:19574226]" /note="hypothetical protein; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome" /db_xref="GeneID:850621" /db_xref="SGD:S000003961" ORIGIN 1 mplldtfksf iqspteskvk qatnedetsg atgtlmneis iltyspktvr eiiqvirkrl 61 llgqnrrnsh rnciqvmktl tlvsylmnng snefikwlkg nmilieiled fqvqdprder 121 kaediqklsr nvlgllqddg llekqrkdvi qfrssistpg rkstdnshlk leemrseltr 181 qslekkakpp ttstsldfqr qrtrntheya rfsldplaee dsedtpgvag gisklsfrpk 241 ssnnpfr // LOCUS NP_013064 503 aa linear PLN 30-JUN-2025 DEFINITION E3 ubiquitin-protein ligase PRP19 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013064 VERSION NP_013064.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181856.1 REFERENCE 1 (residues 1 to 503) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 503) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 503) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 503) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09285. Method: conceptual translation. FEATURES Location/Qualifiers source 1..503 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..503 /product="E3 ubiquitin-protein ligase PRP19" /EC_number="2.3.2.27" /calculated_mol_wt="56439" Region 1..53 /region_name="RING-Ubox_PRP19" /note="U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins; cd16656" /db_xref="CDD:438318" Site order(1,13,15,19..20,22,51..53) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:438318" Region 75..132 /region_name="Prp19" /note="Prp19/Pso4-like; pfam08606" /db_xref="CDD:400774" Region <385..459 /region_name="PRK11028" /note="6-phosphogluconolactonase; Provisional" /db_xref="CDD:182912" CDS 1..503 /gene="PRP19" /locus_tag="YLL036C" /gene_synonym="PSO4" /coded_by="NM_001181856.1:1..1512" /experiment="EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:8194532]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:12627222]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:8248176]" /experiment="EXISTENCE:mutant phenotype:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:12970570]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:12627222]" /note="Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:850623" /db_xref="SGD:S000003959" ORIGIN 1 mlcaisgkvp rrpvlspksr tifekslleq yvkdtgndpi tneplsieei veivpsaqqa 61 sltestnsat lkanysipnl ltslqnewda imlenfklrs tldsltkkls tvmyerdaak 121 lvaaqllmek nedskdlpks sqqavaitre eflqgllqss rdfvargklk apkwpilknl 181 ellqaqnysr niktfpykel nksmyydkwv cmcrcedgal hftqlkdskt ittittpnpr 241 tggehpaiis rgpcnrllll ypgnqitild sktnkvlrei evdsaneiiy myghnevnte 301 yfiwadnrgt igfqsyedds qyivhsaksd veyssgvlhk dslllalysp dgildvynls 361 spdqassrfp vdeeakikev kfadngywmv vecdqtvvcf dlrkdvgtla yptytipefk 421 tgtvtydidd sgknmiaysn esnsltiykf dkktknwtkd eesalclqsd tadftdmdvv 481 cgdggiaail ktndsfniva ltp // LOCUS NP_013065 632 aa linear PLN 30-JUN-2025 DEFINITION polynucleotide 5'-hydroxyl-kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013065 VERSION NP_013065.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181855.1 REFERENCE 1 (residues 1 to 632) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 632) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 632) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 632) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 632) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09286. Method: conceptual translation. FEATURES Location/Qualifiers source 1..632 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..632 /product="polynucleotide 5'-hydroxyl-kinase" /calculated_mol_wt="72127" Region 246..449 /region_name="CLP1_P" /note="mRNA cleavage and polyadenylation factor CLP1 P-loop; pfam16575" /db_xref="CDD:406878" CDS 1..632 /gene="GRC3" /locus_tag="YLL035W" /coded_by="NM_001181855.1:1..1899" /experiment="EXISTENCE:direct assay:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:26638174]" /experiment="EXISTENCE:direct assay:GO:0051731 polynucleotide 5'-hydroxyl-kinase activity [PMID:20814424]" /experiment="EXISTENCE:mutant phenotype:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23175604]" /experiment="EXISTENCE:mutant phenotype:GO:0006363 termination of RNA polymerase I transcription [PMID:20814424]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12837249]" /experiment="EXISTENCE:physical interaction:GO:0030874 nucleolar chromatin [PMID:20814424]" /note="Polynucleotide kinase present on rDNA; required for efficient transcription termination by RNA polymerase I; functions with Las1p in a conserved mechanism to cleave pre-rRNA at a specific site during rRNA processing and ribosome biogenesis; required for cell growth; mRNA is cell-cycle regulated" /db_xref="GeneID:850624" /db_xref="SGD:S000003958" ORIGIN 1 mvidskqdlp qytkdsgses dsdssnnfiv espsipssks atvvlnseey eddegddlng 61 ldaelidnit yegdedetmf vglkekqklh lsgvfrlqvv kggivynnvh ynasreiltf 121 whplsqsipt idfshfagwq dtffmprnnr fkirdeefks fpcvlrvfns nhtglleagh 181 lyrdvnylwk pkepyfplne rttyhllhes driqslsvpg ywstplekly lshknaaydt 241 rimviggkns gkstflrlll ekftqdirds ttsqeelvyl dldpgqpeys lpdsislnki 301 lsspislgqh lcqgsnfqtl lqfyagsssp qdeptsylnc adklidhlee qaffgtslln 361 lpgwikgfgm qilnhiirky kpthllflet anskrhldel tipqsfstsl rdayapevvr 421 vpahslnhtl ssrfhasqlr tfkilalfhk itqfdydfap llksaplqis ygkgksgikg 481 iqfpmefqdl npqdiksale gtvigiytys gedslevksl ntfpilqsct sssknfitlg 541 lihsidtsqq imniyvppch tqildkqped aqwiivrnkt etpfcdflps prtitwddni 601 qipfatferr kklehvwkvr knvmrrgqfm kr // LOCUS NP_013066 837 aa linear PLN 30-JUN-2025 DEFINITION putative AAA family ATPase RIX7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013066 VERSION NP_013066.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181854.1 REFERENCE 1 (residues 1 to 837) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 837) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 837) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 837) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09287. Method: conceptual translation. FEATURES Location/Qualifiers source 1..837 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..837 /product="putative AAA family ATPase RIX7" /calculated_mol_wt="92939" Region <192..824 /region_name="CDC48" /note="AAA family ATPase, CDC48 subfamily; TIGR01243" /db_xref="CDD:273521" CDS 1..837 /gene="RIX7" /locus_tag="YLL034C" /coded_by="NM_001181854.1:1..2514" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11447111|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11447111|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:18559667]" /experiment="EXISTENCE:genetic interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:18559667]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11447111]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:18559667]" /note="Putative ATPase of the AAA family; required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions" /db_xref="GeneID:850625" /db_xref="SGD:S000003957" ORIGIN 1 mvkvkskkns ltssldnkiv dliyrlleek tldrkrslrq esqgeegenn egeededife 61 smffakdlta geiftfcltk dlslqrvkkv vlqktidrml kdvieselee fgsypgynne 121 eeekpsleee lakknmmier dtnemnkrit stwsksgsvs esitetddpk teevkkskkr 181 skegtckvkr qkikedrspp nsslkslggm ddvvaqlmel iglpilhpei flstgveppr 241 gvllhgppgc gktsianala gelqvpfisi sapsvvsgms gesekkirdl fdearslapc 301 lvffdeidai tpkrdggaqr emerrivaql ltsmdeltme ktngkpviii gatnrpdsld 361 aalrragrfd reiclnvpne vsrlhilkkm sdnlkidgai dfaklakltp gfvgadlkal 421 vtaagtcaik rifqtyanik stpttatdss ednmeideta ngdesslknt anmidplpls 481 vvqqfirnyp eplsgeqlsl lsikyedflk alptiqptak regfatvpdv twanvgalqr 541 vrlelnmaiv qpikrpelye kvgisapggv llwgppgcgk tllakavane sranfisikg 601 pellnkyvge sersirqvft rarasvpcvi ffdeldalvp rrdtslsess srvvntllte 661 ldglndrrgi fvigatnrpd midpamlrpg rldkslfiel pnteekldii ktltkshgtp 721 lssdvdfeei irnekcnnfs gadlaalvre ssvlalkrkf fqseeiqsvl dndldkefed 781 lsvgvsgeei ivtmsdfrsa lrkikpsvsd kdrlkydrln kkmglteemk daeemkq // LOCUS NP_013067 230 aa linear PLN 30-JUN-2025 DEFINITION Irc19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013067 VERSION NP_013067.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181853.1 REFERENCE 1 (residues 1 to 230) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 230) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 230) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 230) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09288. Method: conceptual translation. FEATURES Location/Qualifiers source 1..230 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..230 /product="Irc19p" /calculated_mol_wt="27247" CDS 1..230 /gene="IRC19" /locus_tag="YLL033W" /gene_synonym="RRG4" /coded_by="NM_001181853.1:1..693" /experiment="EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:38995433]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:38995433]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:12432101]" /note="Protein involved in DNA double-strand break repair; synergistic defect in DSB repair via single-strand annealing with the RAD52 null mutant; possible role in the end resection process; non-essential gene; null mutant has a sporulation defect, displays increased levels of spontaneous Rad52p foci and has a respiratory growth defect" /db_xref="GeneID:850626" /db_xref="SGD:S000003956" ORIGIN 1 mrkpsititt akaiitpdyt likshskyql psrfqkldad sperstvvkl fyrrfmrlkp 61 fisnvkmvkd tyrdyvrykf mkenyelkry lvfnpdglrs kinlellsnt kccerilpvt 121 emqrtlefvl kscsylpetk vqkwdiardn tycrqilknl ltmqyekyrs ilhrgighde 181 ldvkfshlkt tsspltklnk tekkkiplfk vfsdfdttli ylnetlgtrl // LOCUS NP_013068 825 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLL032C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013068 VERSION NP_013068.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181852.1 REFERENCE 1 (residues 1 to 825) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 825) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 825) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 825) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09289. Method: conceptual translation. FEATURES Location/Qualifiers source 1..825 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..825 /product="uncharacterized protein" /calculated_mol_wt="94467" Region 2..704 /region_name="COG5166" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227495" CDS 1..825 /locus_tag="YLL032C" /coded_by="NM_001181852.1:1..2478" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640|PMID:14562095]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene" /db_xref="GeneID:850627" /db_xref="SGD:S000003955" ORIGIN 1 mdnfkiystv ittaflqvph lyttnrlwkp ieapflvefl qkrisskelk ntkaichidp 61 swvnlnasfi rddmisikat tddmdldaic rislplpmnt ndltaelekm krilldlsek 121 fnleliitke payftpeqtg eskelciyvh algfrsnlme cepqllafvd likkngmtlp 181 pqhyiiepme lnsysvlply mgvdmenfkh israfktsiy apslitlsrd lkanpqiffs 241 gavhslslla rktlresisv nsksffyrrl tnitpgkllf irkyyqqkvn qlilkyqsli 301 rvtneyiefq sistnllemv iknftiqvlh eivevqisln encamspeli idsffghtgn 361 qivvitpked sfnqlivvgn qsstdeasdt silhylsdfi mgsnqvinpn lrqikaifei 421 hpdfedfisg kkngkltrim elsacliqle meeeddnlyl nlvsdsfpdf kesfknvine 481 fpaeesffip evchrpiigt ggsliqatmr khnvfiqfsn sfnlpqnkis mirydnviir 541 cprknkanic lakndlkqiv qeydslqskt lirfssgqyr hilhvngqkn iigqieknen 601 vyimiplkep ldgtsqlsiq gndenasraa nelvnsafgy eyefkidqei dpnkeyefyn 661 livvpflqim niivtfekdl itftfekdtn entltkaiel lsnyletqkt kiifkkiikk 721 fvlgsassks ntsnsntngn frsmnnaksr ttidntsqsg aspqrhkmpv ittvggaqai 781 kgyipntyyn gygygygyty eydynyansn kaqtnnrhky qngrk // LOCUS NP_013069 1017 aa linear PLN 30-JUN-2025 DEFINITION mannose-ethanolamine phosphotransferase GPI13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013069 VERSION NP_013069.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181851.1 REFERENCE 1 (residues 1 to 1017) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1017) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1017) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1017) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1017) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09290. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1017 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1017 /product="mannose-ethanolamine phosphotransferase GPI13" /calculated_mol_wt="115504" Region 77..367 /region_name="GPI_EPT_3" /note="GPI ethanolamine phosphate transferase 3, PIG-O; cd16023" /db_xref="CDD:293747" Site order(89,142,248,290..291) /site_type="active" /note="putative active site [active]" /db_xref="CDD:293747" Site order(89,142,248,291) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:293747" CDS 1..1017 /gene="GPI13" /locus_tag="YLL031C" /gene_synonym="MPC1" /coded_by="NM_001181851.1:1..3054" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:12441642|PMID:10793139]" /experiment="EXISTENCE:mutant phenotype:GO:0016772 transferase activity, transferring phosphorus-containing groups [PMID:10793139]" /experiment="EXISTENCE:mutant phenotype:GO:0051377 mannose-ethanolamine phosphotransferase activity [PMID:12441642]" /note="ER membrane localized phosphoryltransferase; adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein" /db_xref="GeneID:850628" /db_xref="SGD:S000003954" ORIGIN 1 mdektikksi lsssndekii yksrikkfqk nhkfyiillv fiailqfisi afftrgflls 61 rhvldnissq netsklpprf nkavilvida lrfdfaipvn eshsnynlny hnnilslyds 121 fasdkdassl llkfiadppt ttlqrlkglt tgslptfida gsnfdgtvie ednflkqlhl 181 anktvkfagd dtwmalfhpf lsndsfples lnvwdldtvd ngvmdyfhdh lqqdkewdvm 241 ighmlgidhv ghkygpdhft mrekqiqvdq fidwilksid ddtllvilgd hgmdhtgnhg 301 gdsidelest lflyskkpdm wrlketsnyn idnlghdyrs vrqidlvssl allmgqpipf 361 nnlgwpidei arndrewsqf vnsaisqlql ykdtmqihhg ndeileplak nisntpptsd 421 pekfvklghk yqkvflqtce elwakfdyys iatgitllat slvllisitk lipsivvnqm 481 vpefvpgiii mvlvtnlcfh gifyvyqqps fvdqfwgtll ataigiiigc yitifdrynf 541 iwiamrlget ladywsriav mfmiihallf tsnsftiwed rivafllstf gmltlyefvf 601 lpkrqsttal ltatisekeg ttsgvnpsta nsnylpltrf arllggyhsa vliiftrlas 661 miticreeqg eyciptfnnq nnsswwvlgl cflmifilpa citgyynlts syqaaapiwi 721 nvflkgilgl nfvywsltsl ennsaviaip flrdvtifkf tlariiagfs liasnvgwlm 781 gplciklnih ntdvksheat ilgytniygs effllvinvl isillfnkpl aqlsyflmcn 841 qllsileiid llklkeniig pialgllsyq hffttghqat ipsvqwdigf mlsekvtfpf 901 tqiaiilntf gphilvslsv alltlwsqpp dvlkpqtllg rivsncgill tyntilclss 961 fiwvthfrrh lmvwkifcpr fifaslsliv tqlvvtfgti afasgrlikh indifwk // LOCUS NP_001335793 113 aa linear PLN 30-JUN-2025 DEFINITION Rrt7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335793 VERSION NP_001335793.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348853.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80313. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..113 /product="Rrt7p" /calculated_mol_wt="13220" CDS 1..113 /gene="RRT7" /locus_tag="YLL030C" /coded_by="NM_001348853.1:1..342" /note="hypothetical protein; conserved across S. cerevisiae strains; identified in a screen for mutants with increased levels of rDNA transcription" /db_xref="GeneID:850629" /db_xref="SGD:S000003953" ORIGIN 1 myfafkglcg rrflpiasfl tilnrilfqy wlfynslkee ktfqkiffsm nlkcrkkkep 61 nhiiysqppf llgfmvqlqs cvkllplyll fllqgngahy asamtskvls ffl // LOCUS NP_013071 749 aa linear PLN 30-JUN-2025 DEFINITION aminopeptidase P [Saccharomyces cerevisiae S288C]. ACCESSION NP_013071 VERSION NP_013071.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181849.1 REFERENCE 1 (residues 1 to 749) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 749) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 749) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 749) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09291. Method: conceptual translation. FEATURES Location/Qualifiers source 1..749 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..749 /product="aminopeptidase P" /EC_number="3.4.11.9" /calculated_mol_wt="84794" Region 108..274 /region_name="Creatinase_N" /note="Creatinase/Prolidase N-terminal domain; cl46291" /db_xref="CDD:480631" Region 282..460 /region_name="Creatinase_N_2" /note="Creatinase/Prolidase N-terminal domain; pfam16189" /db_xref="CDD:465053" Region 463..688 /region_name="APP" /note="X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; cd01085" /db_xref="CDD:238518" Site order(531,551,562,629,660,674) /site_type="active" /db_xref="CDD:238518" Region 687..749 /region_name="Peptidase_M24_C" /note="C-terminal region of peptidase_M24; pfam16188" /db_xref="CDD:465052" CDS 1..749 /gene="FRA1" /locus_tag="YLL029W" /coded_by="NM_001181849.1:1..2250" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18281282]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18281282]" /experiment="EXISTENCE:genetic interaction:GO:0071281 cellular response to iron ion [PMID:18281282]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18281282]" /experiment="EXISTENCE:mutant phenotype:GO:0071281 cellular response to iron ion [PMID:18281282]" /note="Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation" /db_xref="GeneID:850630" /db_xref="SGD:S000003952" ORIGIN 1 mtskpstsdg rahsishvpg thmrgtsash sprpfrpcad ctcspgllsr qgrraslflr 61 qlensrrsss mllnelkgag ggssagngsv yscdslcavn revnttdrll klrqemkkhd 121 lccyivpscd ehqseyvslr dqrrafisgf sgsagvacit rdllnfnddh pdgksilstd 181 gryfnqarqe ldynwtllrq nedpitwqew cvrealemak glgnkegmvl kigidpklit 241 fndyvsfrkm idtkydakgk velvpveenl vdsiwpdfet lperpcndll llkyefhgee 301 fkdkkekllk klndkassat tgrntfivva ldeicwllnl rgsdidynpv ffsyvained 361 etilftnnpf nddiseyfki ngievrpyeq iwehltkits qassaehefl ipdsaswqmv 421 rclntstnan gaiakkmtaq nfaiihspid vlksikndie iknahkaqvk davclvqyfa 481 wleqqlvgre alideyraae klteirktqr nfmgnsfeti sstgsnaaii hysppvenss 541 midptkiylc dsgsqflegt tditrtihlt kptkeemdny tlvlkgglal erlifpentp 601 gfnidaiarq flwsrgldyk hgtghgigsf lnvhegpmgv gfrphlmnfp lragniisne 661 pgyykdgeyg iriesdmlik katekgnflk fenmtvvpyc rklintklln eeektqiney 721 harvwrtivh flqpqsisyk wlkretspl // LOCUS NP_013072 586 aa linear PLN 30-JUN-2025 DEFINITION polyamine transporter TPO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013072 VERSION NP_013072.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181848.1 REFERENCE 1 (residues 1 to 586) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 586) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 586) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 586) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09292. Method: conceptual translation. FEATURES Location/Qualifiers source 1..586 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..586 /product="polyamine transporter TPO1" /calculated_mol_wt="64141" Region 156..577 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(159..160,163..164,167,199,249..250,252..254,257,277, 280..281,284,386,389..390,393..395,398,421,425,497..498, 502,506,521,524..525,528..529,532) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..586 /gene="TPO1" /locus_tag="YLL028W" /coded_by="NM_001181848.1:1..1761" /experiment="EXISTENCE:direct assay:GO:0000296 spermine transport [PMID:15637075]" /experiment="EXISTENCE:direct assay:GO:0000297 spermine transmembrane transporter activity [PMID:15637075]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15637075|PMID:12562762]" /experiment="EXISTENCE:direct assay:GO:0015606 spermidine transmembrane transporter activity [PMID:15637075]" /experiment="EXISTENCE:direct assay:GO:0015848 spermidine transport [PMID:15637075]" /experiment="EXISTENCE:direct assay:GO:0033101 cellular bud membrane [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000296 spermine transport [PMID:11171066|PMID:15637075|PMID:9920864]" /experiment="EXISTENCE:mutant phenotype:GO:0000297 spermine transmembrane transporter activity [PMID:11171066|PMID:9920864|PMID:15637075]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:15637075]" /experiment="EXISTENCE:mutant phenotype:GO:0015606 spermidine transmembrane transporter activity [PMID:11171066|PMID:15637075]" /experiment="EXISTENCE:mutant phenotype:GO:0015847 putrescine transport [PMID:9920864]" /experiment="EXISTENCE:mutant phenotype:GO:0015848 spermidine transport [PMID:11171066|PMID:15637075|PMID:9920864]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:24136413]" /experiment="EXISTENCE:mutant phenotype:GO:1902047 polyamine transmembrane transport [PMID:24136413]" /note="Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane" /db_xref="GeneID:850631" /db_xref="SGD:S000003951" ORIGIN 1 msdhspisnk enhllpsdss rssssdmhst gttgttgvep vdftgegaky ttategngga 61 dlaiqrtttm nsaaesevni trrltkiltg svnepdrvev dytncapmgg drpyppslps 121 rdlyevtfdg pndplhpfnw pmkkkvllcl vlcldsiaia mcssifasav pqiceiyhvi 181 evvailgitl fvlgfaaspv iyaplselyg rkgvlvlsaf gfalfqfava taenlqtifi 241 crffggfiga apmavvpaaf admfdtnvrg kaialfslgv fvgpilspvm gsyiaqrttw 301 rwleyvvgcf asavfvaivl ffeethhpti lvnkakqmrk qsnnwgihaa hedvelsikd 361 ivqktvtrpi imlfveplll fvtiynsfvy gilyllleay plvfvegygf tengelpyia 421 liigmmvcaa fiwymdndyl krcrakgklv pearlyamvi agtvfpigil wfcwtgyyph 481 kihwmvptvg gafigfglmg iflpclnyii esylllaasa vaantfmrsa fgacfplfag 541 ymfrgmgigw aglllglfaa amipvpllfl kygesirkks kyayaa // LOCUS NP_013073 250 aa linear PLN 30-JUN-2025 DEFINITION Fe-binding Fe/S cluster assembly protein ISA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013073 VERSION NP_013073.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181847.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09293. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..250 /product="Fe-binding Fe/S cluster assembly protein ISA1" /calculated_mol_wt="27544" Region 148..250 /region_name="TIGR00049" /note="Iron-sulfur cluster assembly accessory protein" /db_xref="CDD:272875" CDS 1..250 /gene="ISA1" /locus_tag="YLL027W" /coded_by="NM_001181847.1:1..753" /experiment="EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:21987576]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10805735]" /experiment="EXISTENCE:genetic interaction:GO:0009102 biotin biosynthetic process [PMID:17259550]" /experiment="EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:10805735]" /experiment="EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:17259550]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:10805735|PMID:10748136]" /experiment="EXISTENCE:mutant phenotype:GO:0044572 [4Fe-4S] cluster assembly [PMID:21987576]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:12065597]" /note="Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources; functional ortholog of bacterial A-type ISC proteins; human ISCA1 can complement isa1 null mutant" /db_xref="GeneID:850632" /db_xref="SGD:S000003950" ORIGIN 1 mintgrsrns vllahrflst ggfwrggtng tmsrtinnvn pfklkfipkt vpaaadsvsp 61 dsqrpgkkpf kfivsnqsks skaskspkws syafpsreti ksheeaikkq nkaideqiaa 121 avskndcsct eppkkrkrkl rprkalitls pkaikhlral laqpepklir vsarnrgcsg 181 ltydlqyite pgkfdevveq dgvkividsk alfsiigsem dwiddklask fvfknpnskg 241 tcgcgesfmv // LOCUS NP_013074 908 aa linear PLN 30-JUN-2025 DEFINITION chaperone ATPase HSP104 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013074 VERSION NP_013074.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181846.1 REFERENCE 1 (residues 1 to 908) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 908) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 908) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 908) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 908) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 908) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 908) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 908) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 908) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09294. Method: conceptual translation. FEATURES Location/Qualifiers source 1..908 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..908 /product="chaperone ATPase HSP104" /calculated_mol_wt="101904" Region 1..863 /region_name="ClpA" /note="ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones]; COG0542" /db_xref="CDD:440308" CDS 1..908 /gene="HSP104" /locus_tag="YLL026W" /coded_by="NM_001181846.1:1..2727" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10467108]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10467108|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:9674429]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:16135516]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:24291094]" /experiment="EXISTENCE:direct assay:GO:0035617 stress granule disassembly [PMID:24291094]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:16135516]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:9674429]" /experiment="EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:11867765]" /experiment="EXISTENCE:mutant phenotype:GO:0005991 trehalose metabolic process [PMID:9797333]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:9674429|PMID:16135516]" /experiment="EXISTENCE:mutant phenotype:GO:0034975 protein folding in endoplasmic reticulum [PMID:10931304]" /experiment="EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:7984243]" /experiment="EXISTENCE:mutant phenotype:GO:0043531 ADP binding [PMID:11867765]" /experiment="EXISTENCE:mutant phenotype:GO:0070370 cellular heat acclimation [PMID:2188365]" /note="Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate denatured, protein aggregates; responds to stresses (heat, ethanol, and sodium arsenite); required for the protein aggregate solid-to-liquid phase transition and dispersal of liquid condensates; involved in [PSI+] propagation; potentiated variants eliminate TDP-43 cytoplasmic aggregates to reduce proteotoxicity; becomes more abundant and forms cytoplasmic foci during replication stress" /db_xref="GeneID:850633" /db_xref="SGD:S000003949" ORIGIN 1 mndqtqfter altiltlaqk lasdhqhpql qpihilaafi etpedgsvpy lqnliekgry 61 dydlfkkvvn rnlvripqqq papaeitpsy algkvlqdaa kiqkqqkdsf iaqdhilfal 121 fndssiqqif keaqvdieai kqqalelrgn tridsrgadt ntpleylsky aidmteqarq 181 gkldpvigre eeirstirvl arriksnpcl igepgigkta iiegvaqrii dddvptilqg 241 aklfsldlaa ltagakykgd feerfkgvlk eieesktliv lfideihmlm gngkddaani 301 lkpalsrgql kvigattnne yrsivekdga ferrfqkiev aepsvrqtva ilrglqpkye 361 ihhgvrilds alvtaaqlak rylpyrrlpd saldlvdisc agvavardsk peeldskerq 421 lqliqveika lerdedadst tkdrlklarq keaslqeele plrqryneek hgheeltqak 481 kkldelenka ldaerrydta taadlryfai pdikkqiekl edqvaeeerr agansmiqnv 541 vdsdtiseta arltgipvkk lsesenekli hmerdlssev vgqmdaikav snavrlsrsg 601 lanprqpasf lflglsgsgk telakkvagf lfndedmmir vdcselseky avskllgtta 661 gyvgydeggf ltnqlqykpy svllfdevek ahpdvltvml qmlddgrits gqgktidcsn 721 civimtsnlg aefinsqqgs kiqestknlv mgavrqhfrp eflnrissiv ifnklsrkai 781 hkivdirlke ieerfeqndk hyklnltqea kdflakygys ddmgarplnr liqneilnkl 841 alrilkneik dketvnvvlk kgksrdenvp eeaeeclevl pnheatigad tlgdddneds 901 meidddld // LOCUS NP_013075 124 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013075 VERSION NP_013075.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181845.1 REFERENCE 1 (residues 1 to 124) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 124) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 124) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 124) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09295. Method: conceptual translation. FEATURES Location/Qualifiers source 1..124 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..124 /product="seripauperin PAU17" /calculated_mol_wt="12962" Region 26..118 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..124 /gene="PAU17" /locus_tag="YLL025W" /coded_by="NM_001181845.1:1..375" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; YLL025W is not an essential gene" /db_xref="GeneID:850635" /db_xref="SGD:S000003948" ORIGIN 1 mvkltsiaag vaaiaagvaa apatttlsps dervnlvelg vyvsdirahl aeyymfqaah 61 ptetypveia eavfnygdft tmltgipadq vtrvitgvpw ystrlrpais salsadgiyt 121 avpn // LOCUS NP_013076 639 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family chaperone SSA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013076 VERSION NP_013076.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181844.1 REFERENCE 1 (residues 1 to 639) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 639) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 639) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 639) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 639) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09296. Method: conceptual translation. FEATURES Location/Qualifiers source 1..639 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..639 /product="Hsp70 family chaperone SSA2" /calculated_mol_wt="69339" Region 4..639 /region_name="PTZ00009" /note="heat shock 70 kDa protein; Provisional" /db_xref="CDD:240227" CDS 1..639 /gene="SSA2" /locus_tag="YLL024C" /gene_synonym="YG102" /coded_by="NM_001181844.1:1..1920" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:25853343]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:10745074]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:10893257]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8755907]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16806052|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16806052]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:7867784]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:8755907]" /experiment="EXISTENCE:direct assay:GO:1903561 extracellular vesicle [PMID:38711329]" /experiment="EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:27178214]" /experiment="EXISTENCE:genetic interaction:GO:0051082 unfolded protein binding [PMID:9789005]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9448096]" /experiment="EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:8754838]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:25853343]" /experiment="EXISTENCE:mutant phenotype:GO:0035719 tRNA import into nucleus [PMID:33074312|PMID:25853343]" /note="HSP70 family ATP-binding protein; role in protein folding and vacuolar protein import; required for Ub-dependent degradation of short-lived proteins; associated with the chaperonin-containing T-complex; unique specificity in propagation of [URE3] prions and vacuolar degradation of gluconeogenic enzymes; contributes to tRNA nuclear import during starvation; targeted to vacuoles via the AP-3 pathway; localizes to exosomes during heat stress with a role in thermotolerance; 98% identity with Ssa1p" /db_xref="GeneID:850636" /db_xref="SGD:S000003947" ORIGIN 1 mskavgidlg ttyscvahfs ndrvdiiand qgnrttpsfv gftdterlig daaknqaamn 61 pantvfdakr ligrnfndpe vqgdmkhfpf klidvdgkpq iqvefkgetk nftpeqissm 121 vlgkmketae sylgakvnda vvtvpayfnd sqrqatkdag tiaglnvlri ineptaaaia 181 ygldkkgkee hvlifdlggg tfdvsllsie dgifevkata gdthlggedf dnrlvnhfiq 241 efkrknkkdl stnqralrrl rtacerakrt lsssaqtsve idslfegidf ytsitrarfe 301 elcadlfrst ldpvekvlrd akldksqvde ivlvggstri pkvqklvtdy fngkepnrsi 361 npdeavayga avqaailtgd essktqdlll ldvaplslgi etaggvmtkl iprnstiptk 421 ksevfstyad nqpgvliqvf egeraktkdn nllgkfelsg ippaprgvpq ievtfdvdsn 481 gilnvsavek gtgksnkiti tndkgrlske diekmvaeae kfkeedekes qriasknqle 541 siayslknti seagdkleqa dkdavtkkae etiawldsnt tatkeefddq lkelqevanp 601 imsklyqagg apegaapggf pggappapea egptveevd // LOCUS NP_013077 279 aa linear PLN 30-JUN-2025 DEFINITION nucleoporin POM33 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013077 VERSION NP_013077.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181843.1 REFERENCE 1 (residues 1 to 279) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 279) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 279) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 279) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09297. Method: conceptual translation. FEATURES Location/Qualifiers source 1..279 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..279 /product="nucleoporin POM33" /calculated_mol_wt="32055" Region 19..264 /region_name="TMEM33_Pom33" /note="Transmembrane protein 33/Nucleoporin POM33; pfam03661" /db_xref="CDD:461009" CDS 1..279 /gene="POM33" /locus_tag="YLL023C" /coded_by="NM_001181843.1:1..840" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:20498018]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:20498018]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20498018|PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:20498018]" /experiment="EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:20498018]" /note="Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850637" /db_xref="SGD:S000003946" ORIGIN 1 mssrpannqg ppnlpardks lvqrfmavak slqfawftgh svvlissily llkmsefyyr 61 saylgviesf giiiyqqfft rneplqtqda aatkasiksr vagllksedv lylvlanfwl 121 ftprfsfsli pffafavfhv liyvekvllp kvfhlsskds skilsfidkf vvqyndlcmh 181 wvgtaellif ilvlfrailc fqrswiilvv yaifiklrye nskymkaafa qwrvrmdgii 241 shpsippfvk raynaikmsl irlseyrlsg apqvtkkqn // LOCUS NP_013078 385 aa linear PLN 30-JUN-2025 DEFINITION Hif1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013078 VERSION NP_013078.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181842.1 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09298. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..385 /product="Hif1p" /calculated_mol_wt="43297" Region 237..273 /region_name="SHNi-TPR" /note="pfam10516" /db_xref="CDD:402238" CDS 1..385 /gene="HIF1" /locus_tag="YLL022C" /coded_by="NM_001181842.1:1..1158" /experiment="EXISTENCE:direct assay:GO:0000123 histone acetyltransferase complex [PMID:14761951|PMID:15099519]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:14761951]" /experiment="EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:15099519]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:15099519]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:14761951|PMID:15099519]" /experiment="EXISTENCE:mutant phenotype:GO:0000123 histone acetyltransferase complex [PMID:14761951]" /experiment="EXISTENCE:physical interaction:GO:0000123 histone acetyltransferase complex [PMID:14761951]" /note="Non-essential component of the HAT-B histone acetyltransferase complex; localized to the nucleus; has a role in telomeric silencing; other members are Hat1p and Hat2p" /db_xref="GeneID:850638" /db_xref="SGD:S000003945" ORIGIN 1 mklraedvla ngtsrhkvqi dmerqvqiak dllaqkkfle aakrcqqtld slpkdgllpd 61 pelftifaqa vynmevqnsg nlfgdallag ddgsgseses epesdvsnge egnengqtei 121 pnsrmfqfdq eeedltgdvd sgdsedsgeg seeeeenvek eeerlalhel anfspanehd 181 deiedvsqlr ksgfhiyfen dlyenaldll aqalmllgrp tadgqslten srlrigdvyi 241 lmgdiereae mfsraihhyl kalgyyktlk paeqvtekvi qaeflvcdal rwvdqvpakd 301 klkrfkhaka llekhmttrp kdselqqarl aqiqddidev qenqqhgskr plsqpttsig 361 fpalekplgd fndlsqlvkk kprrh // LOCUS NP_013079 1466 aa linear PLN 30-JUN-2025 DEFINITION Spa2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013079 VERSION NP_013079.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181841.1 REFERENCE 1 (residues 1 to 1466) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1466) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1466) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1466) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1466) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09299. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1466 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1466 /product="Spa2p" /calculated_mol_wt="163012" Region 44..71 /region_name="GIT_SHD" /note="Spa2 homology domain (SHD) of GIT; pfam08518" /db_xref="CDD:462506" Region 94..122 /region_name="GIT_SHD" /note="Spa2 homology domain (SHD) of GIT; pfam08518" /db_xref="CDD:462506" Region 876..1042 /region_name="DUF4573" /note="Domain of unknown function (DUF4573); pfam15140" /db_xref="CDD:434493" Region 1324..1450 /region_name="GIT1_C" /note="G protein-coupled receptor kinase-interacting protein 1 C term; pfam12205" /db_xref="CDD:463492" CDS 1..1466 /gene="SPA2" /locus_tag="YLL021W" /gene_synonym="FUS6; PEA1; PPF1" /coded_by="NM_001181841.1:1..4401" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9214378]" /experiment="EXISTENCE:direct assay:GO:0000133 polarisome [PMID:9632790]" /experiment="EXISTENCE:direct assay:GO:0005078 MAP-kinase scaffold activity [PMID:12361575]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12361575|PMID:2647769]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9214378]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:23673619]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9214378|PMID:2647769]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:12857882]" /experiment="EXISTENCE:genetic interaction:GO:0036267 invasive filamentous growth [PMID:9443897]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:12857882]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:8909546|PMID:8013906]" /experiment="EXISTENCE:mutant phenotype:GO:0005078 MAP-kinase scaffold activity [PMID:12361575]" /experiment="EXISTENCE:mutant phenotype:GO:0005934 cellular bud tip [PMID:16166638]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:8909546]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9443897|PMID:9055077]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:8909546|PMID:8013906]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:12857882|PMID:10085294|PMID:16166638|PMID:8909546|PM ID:9571251|PMID:11740491|PMID:9632790]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:12857882|PMID:19633059]" /experiment="EXISTENCE:mutant phenotype:GO:0071468 cellular response to acidic pH [PMID:19633059]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:12857882]" /note="Component of the polarisome; functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate; coding sequence contains length polymorphisms in different strains; SPA2 has a paralog, SPH1, that arose from the whole genome duplication" /db_xref="GeneID:850639" /db_xref="SGD:S000003944" ORIGIN 1 mgtssevsla hhrdifhyyv slktffevtg enrdrsnstr aqkarakllk lsssqfyels 61 tdvsdelqrr igedanqpdy llpkanfhmk rnqarqklan lsqtrfndll ddilfeikrr 121 gfdkdldapr pplpqpmkqe vskdsddtar tstnsssvtq vapnvsvqps lvipkmasid 181 wsseeeeeeq vkekpnepeg kqtsmdekke akpalnpivt dsdlpdsqvl arditsmart 241 pttthknywd vndspiikvd kdidnekgpe qlkspevqra ennnpnseme dkvkeltdln 301 sdlhlqiedl naklasltse kekekkeeke ekekeknlki nytidesfqk ellslnsqig 361 elsienenlk qkisefelhq kkndnhndlk itdgfiskys sadglipaqy ilnannliiq 421 fttrlsavpi gdstaishqi geelfqilsq lsnlisqlll sadllqykdq villkaslsh 481 aitsiryfsv ygpvlipkit vqaavsevcf amcnlidsak iksdsngest tsnegnrqvl 541 eyssptattp mtptfpstsg inmkkgfinp rkpasflndv eeeespvkpl kitqkainsp 601 iirpsssngv pttsrkpsgt glfslmidss iaknsshked ndkyvspika vtsasnsass 661 niseipkltl ppqakigtvi ppsenqvpni kienteednk rsditneisv kptssiadkl 721 kqfeqssekk sspkenpiak eemdskpkls nkfitsmndv stddsssdgn enddaddddd 781 ftymalkqtm kregskiekn ndsklpaniv eldlhespes vkiespesik eitssemsse 841 mpssslpkrl vedvepsemp ekgasvesvr kknfqeplgn vespdmtqkv kslgmtgkav 901 gpesdsrves pgmtgqiksl nmagkvvgpe adsrvespgm keqikslgmt gkitaqesik 961 speaarklas sgevdkiesp rmvresesle avgntipsnm tvkmespnlk gntvsepqei 1021 rrdiassepi envdppkvlk kivfpkavnr tgspksvekt pssatlkksg lpepnsqivs 1081 pelaknspla pikknvelre tnkphtetit sveptnkdan tswrdadlnr tikreeeded 1141 fdrvnhniqi tgaytktgki dyhkipvdrk akseaevhts eedidesnnv ngkradaqih 1201 iterkhafvn ptensqvkkt shspflnskp vqyensesng ginnhikikn tgettahdek 1261 hysddddssy qfvpmkheeq eqeqnrseee esedddeeee dsdfdvdtfd ienpdntlse 1321 lllylehqtm dvistiqsll tsikkpqvtk gnlrgesnai nqvigqmvda tsismeqsrn 1381 anlkkhgdwv vqslrdcsrr mtilcqltgd gilakeksdq dyadknfkqr lagiafdvak 1441 ctkelvktve easlkdeiny lnsklk // LOCUS NP_013081 737 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase KNS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013081 VERSION NP_013081.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181839.1 REFERENCE 1 (residues 1 to 737) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 737) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 737) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 737) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09300. Method: conceptual translation. FEATURES Location/Qualifiers source 1..737 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..737 /product="serine/threonine protein kinase KNS1" /EC_number="2.7.12.1" /calculated_mol_wt="83712" Region 298..720 /region_name="PKc_CLK" /note="Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; cd14134" /db_xref="CDD:271036" Site order(319..323,327,341,343,357,377,393..396,399,401..402, 440,442,444..445,447,490,493,502,504..507,509,546) /site_type="active" /db_xref="CDD:271036" Site order(319..322,327,341,343,377,393..396,399,402,444..445, 447,489..490) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271036" Site order(357,401,440,442,493,502,504..507,509,546) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271036" Site 489..509 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271036" CDS 1..737 /gene="KNS1" /locus_tag="YLL019C" /coded_by="NM_001181839.1:1..2214" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:25631054|PMID:8910305]" /experiment="EXISTENCE:direct assay:GO:0004713 protein tyrosine kinase activity [PMID:8910305]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22364741]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22364741]" /experiment="EXISTENCE:direct assay:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:22364741]" /experiment="EXISTENCE:genetic interaction:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:22364741]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:8910305]" /experiment="EXISTENCE:mutant phenotype:GO:0004713 protein tyrosine kinase activity [PMID:8910305]" /experiment="EXISTENCE:mutant phenotype:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:22364741]" /note="Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation" /db_xref="GeneID:850641" /db_xref="SGD:S000003942" ORIGIN 1 msqniqigtr krsranmnns tttgpannts snktfldnfe etrtnkllde mfarqnsflt 61 dnlrnsldln qadnplrprq hqhqlfldne naieldeepr iinttinnsn nhnssrvded 121 adddiifike qpiqfsspli lpssssinnn nnivtsnnpg cgtaatsnst yittpkkfkk 181 qrtislpqlp lsklsyqsny fnvpdqtnai vprvtqtene llhltgscak tlegnkavnl 241 tiahstspfs nppaqiaslp qsnlkkqigs slrkftsngs sesassnksn fktdkdghyv 301 yqendifgsg grfvvkdllg qgtfgkvlkc idnkyepnyv avkviravdr yreaaktelr 361 ilqtilnndp qgqfqclllr ecfdyknhic lvtdlygrsi ydfmcsngia rfpgshiqai 421 arqlirsvcf lhdlgiihtd lkpenilicd ethiaqklpl ktvqslskrr reaskgkrki 481 lknpeikiid fgsaifhyey hppvistrhy rapeivlglg wsfpcdiwsi acvlvelvig 541 eslypihenl ehmammqrin gtpfptdiid kmfykskhkl gnspsdlnst vikhfdrktl 601 slqwpeknkr gdtitteksm krvlqscdrl diyiskvlkq dygdslsinw nlppeknwsl 661 insklawkrq thsssssttd eldketflfw ywfidllrkm fefdptkrit akdaldhewf 721 nlgilddgia tynntqg // LOCUS NP_013082 98 aa linear PLN 30-JUN-2025 DEFINITION Cox19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013082 VERSION NP_013082.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184338.1 REFERENCE 1 (residues 1 to 98) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 98) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 98) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 98) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09301. Method: conceptual translation. FEATURES Location/Qualifiers source 1..98 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..98 /product="Cox19p" /calculated_mol_wt="10974" CDS 1..98 /gene="COX19" /locus_tag="YLL018C-A" /coded_by="NM_001184338.1:1..297" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:17237235]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:12171940]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12171940]" /experiment="EXISTENCE:direct assay:GO:0030001 metal ion transport [PMID:12171940]" /experiment="EXISTENCE:direct assay:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:12171940]" /note="Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs" /db_xref="GeneID:850642" /db_xref="SGD:S000007245" ORIGIN 1 msgnpgssls alrptpperg sfpldhdgec tkymqeylkc mqlvqnenam ncrllakdyl 61 rcrmdhqlmd ydewshlglp edapgnngkt ikdatdnk // LOCUS NP_013083 557 aa linear PLN 30-JUN-2025 DEFINITION aspartate--tRNA ligase DPS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013083 VERSION NP_013083.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181838.1 REFERENCE 1 (residues 1 to 557) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 557) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 557) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 557) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09302. Method: conceptual translation. FEATURES Location/Qualifiers source 1..557 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..557 /product="aspartate--tRNA ligase DPS1" /EC_number="6.1.1.12" /calculated_mol_wt="63385" Region 19..557 /region_name="PLN02850" /note="aspartate-tRNA ligase" /db_xref="CDD:215456" CDS 1..557 /gene="DPS1" /locus_tag="YLL018C" /coded_by="NM_001181838.1:1..1674" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:12888345]" /experiment="EXISTENCE:direct assay:GO:0004815 aspartate-tRNA ligase activity [PMID:8263943]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16113655]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16113655]" /experiment="EXISTENCE:direct assay:GO:0006422 aspartyl-tRNA aminoacylation [PMID:8263943]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation; shares five highly conserved amino acids with human that when mutated cause leukoencephalopathy characterized by hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL)" /db_xref="GeneID:850643" /db_xref="SGD:S000003941" ORIGIN 1 msqdenivka veesaepaqv ilgedgkpls kkalkklqke qekqrkkeer alqleaerea 61 rekkaaaedt akdnygklpl iqsrdsdrtg qkrvkfvdld eakdsdkevl frarvhntrq 121 qgatlafltl rqqasliqgl vkankegtis knmvkwagsl nlesivlvrg ivkkvdepik 181 satvqnleih itkiytiset pealpilled asrseaeaea aglpvvnldt rldyrvidlr 241 tvtnqaifri qagvcelfre ylatkkftev htpkllgaps eggssvfevt yfkgkaylaq 301 spqfnkqqli vadfervyei gpvfraensn thrhmteftg ldmemafeeh yhevldtlse 361 lfvfifselp krfaheielv rkqypveefk lpkdgkmvrl tykegiemlr aagkeigdfe 421 dlstenekfl gklvrdkydt dfyildkfpl eirpfytmpd panpkysnsy dffmrgeeil 481 sgaqrihdha llqermkahg lspedpglkd ycdgfsygcp phagggigle rvvmfyldlk 541 nirraslfpr dpkrlrp // LOCUS NP_013086 1559 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette bilirubin transporter BPT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013086 VERSION NP_013086.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181835.1 REFERENCE 1 (residues 1 to 1559) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1559) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1559) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1559) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09303. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1559 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1559 /product="ATP-binding cassette bilirubin transporter BPT1" /calculated_mol_wt="176744" Region 222..1556 /region_name="MRP_assoc_pro" /note="multi drug resistance-associated protein (MRP); TIGR00957" /db_xref="CDD:188098" CDS 1..1559 /gene="BPT1" /locus_tag="YLL015W" /coded_by="NM_001181835.1:1..4680" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:12455987|PMID:23658021]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015086 cadmium ion transmembrane transporter activity [PMID:12455987]" /experiment="EXISTENCE:direct assay:GO:0015691 cadmium ion transport [PMID:12455987]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:23658021]" /note="ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p" /db_xref="GeneID:850645" /db_xref="SGD:S000003938" ORIGIN 1 msslevvdgc pygyrpypds gtnalnpcfi svisawqavf flligsyqlw klyknnkvpp 61 rfknfptlps kinsrhlthl tnvcfqstli icelalvsqs sdrvypfilk kalylnllfn 121 lgislptqyl ayfkstfsmg nqlfyymfqi llqlflilqr yyhgssnerl tvisgqtami 181 levlllfnsv aifiydlcif epinelseyy kkngwyppvh vlsyitfiwm nklivetyrn 241 kkikdpnqlp lppvdlniks iskefkanwe lekwlnrnsl wraiwksfgr tisvamlyet 301 tsdllsvvqp qflrifidgl npetsskypp lngvfialtl fvisvvsvfl tnqfyigife 361 aglgirgsla slvyqkslrl tlaernekst gdilnlmsvd vlriqrffen aqtiigapiq 421 iivvltslyw llgkaviggl vtmaimmpin aflsrkvkkl sktqmkykdm riktitelln 481 aiksiklyaw eepmmarlnh vrndmelknf rkigivsnli yfawncvplm vtcstfglfs 541 lfsdsplspa ivfpslslfn ilnsaiysvp smintiiets vsmerlksfl lsdeiddsfi 601 eridpsader alpaiemnni tflwkskevl tssqsgdnlr tdeesiigss qialknidhf 661 eakrgdlvcv vgrvgagkst flkailgqlp cmsgsrdsip pkliirsssv aycsqeswim 721 nasvrenilf ghkfdqdyyd ltikacqllp dlkilpdgde tlvgekgisl sggqkarlsl 781 aravysradi yllddilsav daevskniie yvligktall knktiilttn tvsilkhsqm 841 iyalengeiv eqgnyedvmn rknntsklkk lleefdspid ngnesdvqte hrsesevdep 901 lqlkvteset edevvtesel elikansrra slatlrprpf vgaqldsvkk taqkaektev 961 grvktkiyla yikacgvlgv vlfflfmilt rvfdlaenfw lkywsesnek ngsnervwmf 1021 vgvysligva saafnnlrsi mmllycsirg skklhesmak svirspmtff ettpvgriin 1081 rfssdmdavd snlqyifsff fksiltylvt vilvgynmpw flvfnmflvv iyiyyqtfyi 1141 vlsrelkrli sisyspimsl mseslngysi idaydhferf iylnyekiqy nvdfvfnfrs 1201 tnrwlsvrlq tigativlat ailalatmnt krqlssgmvg llmsyslevt gsltwivrtt 1261 vtietnivsv eriveycelp peaqsinpek rpdenwpskg giefknystk yrenldpvln 1321 ninvkiepce kvgivgrtga gkstlslalf rileptegki iidgidisdi glfdlrshla 1381 iipqdaqafe gtvktnldpf nrysedelkr aveqahlkph lekmlhskpr gddsneedgn 1441 vndildvkin engsnlsvgq rqllclaral lnrskilvld eatasvdmet dkiiqdtirr 1501 efkdrtilti ahridtvlds dkiivldqgs vrefdspskl lsdktsifys lcekggylk // LOCUS NP_013087 108 aa linear PLN 30-JUN-2025 DEFINITION Emc6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013087 VERSION NP_013087.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181834.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09304. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..108 /product="Emc6p" /calculated_mol_wt="12273" Region 24..101 /region_name="EMC6" /note="pfam07019" /db_xref="CDD:462067" CDS 1..108 /gene="EMC6" /locus_tag="YLL014W" /coded_by="NM_001181834.1:1..327" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0072546 EMC complex [PMID:19325107]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]" /note="Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93" /db_xref="GeneID:850646" /db_xref="SGD:S000003937" ORIGIN 1 mssneevftq inatanvvdn kkrllfvqds salvlglvag flqiesvhgf iwflilynli 61 nviyivwicq lqpgkfyqsp lhdiffesff reitgfvmaw tfgyalig // LOCUS NP_013088 879 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding protein PUF3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013088 VERSION NP_013088.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181833.1 REFERENCE 1 (residues 1 to 879) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 879) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 879) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 879) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 879) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 879) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 879) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 879) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 879) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09305. Method: conceptual translation. FEATURES Location/Qualifiers source 1..879 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..879 /product="mRNA-binding protein PUF3" /calculated_mol_wt="97937" Region 54..876 /region_name="COG5099" /note="RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]" /db_xref="CDD:227430" CDS 1..879 /gene="PUF3" /locus_tag="YLL013C" /coded_by="NM_001181833.1:1..2640" /experiment="EXISTENCE:direct assay:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:16317069]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640|PMID:11101532]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12730603]" /experiment="EXISTENCE:direct assay:GO:0032473 cytoplasmic side of mitochondrial outer membrane [PMID:17210948]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11101532]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:17210948]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:18523582]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:17210948]" /experiment="EXISTENCE:mutant phenotype:GO:0010795 regulation of ubiquinone biosynthetic process [PMID:29248374]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:26051939]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:26051939]" /experiment="EXISTENCE:mutant phenotype:GO:0051646 mitochondrion localization [PMID:17210948]" /note="Protein of the mitochondrial outer surface; links the Arp2/3 complex with the mitochondria during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins; translationally represses oxidative stress-linked genes; regulates CoQ biosynthesis" /db_xref="GeneID:850647" /db_xref="SGD:S000003936" ORIGIN 1 memnmdmdmd melasivssl salshsnnng gqaaaagivn ggaagsqqig gfrrssftta 61 nevdseilll hgssesspif kktalsvgta ppfstnskkf fgnggnyyqy rstdtaslss 121 asynnyhthh taanlgknnk vnhllgqysa siagpvyyng ndnnnsggeg ffekfgksli 181 dgtrelesqd rpdavntqsq fisksvsnas ldtqntfeqn vesdknfnkl nrnttnsgsl 241 yhsssnsgss aslesenahy pkrniwnvan tpvfrpsnnp aavgatnval pnqqdgpann 301 nfppymngfp pnqfhqgphy qnfpnyligs psnfisqmis vqipanedte dsngkkkkka 361 nrpssvssps sppnnspfpf aypnpmmfmp ppplsapqqq qqqqqqqqqe dqqqqqqqen 421 pyiyyptpnp ipvkmpkdek tfkkrnnknh pannsnnank qanpylensi ptkntskkna 481 ssksnestan nhkshshshp hsqslqqqqq tyhrsplleq lrnsssdkns nsnmslkdif 541 ghslefckdq hgsrfiqrel atspasekev ifneirddai elsndvfgny viqkffefgs 601 kiqkntlvdq fkgnmkqlsl qmyacrviqk aleyidsnqr ielvlelsds vlqmikdqng 661 nhviqkaiet ipieklpfil ssltghiyhl sthsygcrvi qrllefgsse dqesilnelk 721 dfipyliqdq ygnyviqyvl qqdqftnkem vdikqeiiet vannvveysk hkfasnvvek 781 silygsknqk dliiskilpr dknhalnled dspmilmikd qfanyviqkl vnvsegegkk 841 liviairayl dklnksnslg nrhlasvekl aalvenaev // LOCUS NP_013089 573 aa linear PLN 30-JUN-2025 DEFINITION sterol esterase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013089 VERSION NP_013089.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181832.1 REFERENCE 1 (residues 1 to 573) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 573) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 573) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 573) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09306. Method: conceptual translation. FEATURES Location/Qualifiers source 1..573 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..573 /product="sterol esterase" /EC_number="3.1.1.13" /calculated_mol_wt="66377" Region 169..>326 /region_name="PLN02872" /note="triacylglycerol lipase" /db_xref="CDD:215470" Region 178..241 /region_name="Abhydro_lipase" /note="Partial alpha/beta-hydrolase lipase region; pfam04083" /db_xref="CDD:461162" CDS 1..573 /gene="YEH1" /locus_tag="YLL012W" /coded_by="NM_001181832.1:1..1722" /experiment="EXISTENCE:direct assay:GO:0004771 sterol ester esterase activity [PMID:15713625]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:14562095|PMID:15713625]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15713625]" /experiment="EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:15713625]" /note="Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes; YEH1 has a paralog, YEH2, that arose from the whole genome duplication" /db_xref="GeneID:850648" /db_xref="SGD:S000003935" ORIGIN 1 mgvsavlkra rnllatfivc cfmavvlvla lahhfinehr dtrssstqie vddeskrnvh 61 hdhvltrtna yatpyldleh dkkngivydh trtvvrkknh evgssslhkn lfhkfltkli 121 frfiekekvt egvtqgkfnn ssneianhep vfekipvqcd nplqnlilse dltlvadlny 181 yfnqyniqie efrletedgf vidlwhlipk yrttdsdkkk rppilmlhgl lqssgsfasn 241 grkslayfly qsgydiwlgn nrcgfrpewn eakvptlasr wdwdlremvk ydltllidtv 301 laktqfeklt lishsqgttq gfmglvnedk ffppgsgske sfftskiany ialapavypg 361 pllneklfvk lmtkeienpw ffgetsffei mmivrnlcvg eslfsfvcyt ifnylfdwnd 421 tlwdtalrdr hflfspvhvs vklmqwwlsp dpnkvsfkfg shkmfpdnvk wfsdaskapn 481 iylfvpkqdr lvdgerlinh fvnvesnvny kiwyideyah idvlwahdvi erigkpilqn 541 lnnyyskkps safesdcsdt evetelemva eka // LOCUS NP_013090 489 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein SOF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013090 VERSION NP_013090.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181831.1 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09307. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..489 /product="rRNA-processing protein SOF1" /calculated_mol_wt="56658" Region <65..376 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 114..178 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 182..215 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 223..259 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 264..302 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 308..344 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 351..375 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 377..461 /region_name="Sof1" /note="Sof1-like domain; pfam04158" /db_xref="CDD:427753" CDS 1..489 /gene="SOF1" /locus_tag="YLL011W" /coded_by="NM_001181831.1:1..1470" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:8508778|PMID:15367670]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8508778]" /note="Protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p; essential gene" /db_xref="GeneID:850649" /db_xref="SGD:S000003934" ORIGIN 1 mkiktikrsa ddyvpvkstq esqmprnlnp elhpferare ytkalnatkl ermfakpfvg 61 qlgyghrdgv yaiaknygsl nklatgsadg vikywnmstr eefvsfkahy glvtglcvtq 121 prfhdkkpdl ksqnfmlscs ddktvklwsi nvddysnkns sdndsvtnee glirtfdges 181 afqgidshre nstfatggak ihlwdvnrlk pvsdlswgad nitslkfnqn etdilastgs 241 dnsivlydlr tnsptqkivq tmrtnaicwn pmeafnfvta nedhnayyyd mrnlsrslnv 301 fkdhvsavmd vdfsptgdei vtgsydksir iyktnhghsr eiyhtkrmqh vfqvkysmds 361 kyiisgsddg nvrlwrskaw ersnvkttre knkleydekl kerfrhmpei krisrhrhvp 421 qvikkaqeik nielssikrr eanerrtrkd mpyiserkkq ivgtvhkyed sgrdrkrrke 481 ddkrdtqek // LOCUS NP_013091 427 aa linear PLN 30-JUN-2025 DEFINITION phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013091 VERSION NP_013091.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181830.1 REFERENCE 1 (residues 1 to 427) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 427) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 427) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 427) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09308. Method: conceptual translation. FEATURES Location/Qualifiers source 1..427 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..427 /product="phosphatase" /calculated_mol_wt="47800" Region 257..412 /region_name="HIF-SF_euk" /note="Dullard-like phosphatase domain; TIGR02251" /db_xref="CDD:274055" Site order(263..267,271..272,318..321,325,357,373..374,376..378) /site_type="active" /db_xref="CDD:319823" Site 263..267 /site_type="other" /note="HAD signature motif I" /db_xref="CDD:319823" CDS 1..427 /gene="PSR1" /locus_tag="YLL010C" /coded_by="NM_001181830.1:1..1284" /experiment="EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:10777497]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10777497]" /experiment="EXISTENCE:genetic interaction:GO:0034198 cellular response to amino acid starvation [PMID:30142151]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:12090248]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12090248]" /experiment="EXISTENCE:genetic interaction:GO:1904262 negative regulation of TORC1 signaling [PMID:30142151]" /experiment="EXISTENCE:mutant phenotype:GO:0034198 cellular response to amino acid starvation [PMID:30142151]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:30142151]" /note="Plasma membrane-associated protein phosphatase; involved in the general stress response and the inactivating dephosphorylation of Mep2p; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr2p; member of the HAD family of protein phosphatases" /db_xref="GeneID:850650" /db_xref="SGD:S000003933" ORIGIN 1 mgfissilcc ssettqsnsn sayrqqqsss lnknrsvkhs ntksrtrgvh qtnsppsktn 61 saatfsster stgksgistn dnekkkpssp taavtatttn nmtkvekris kddlyeekye 121 vdedeeidde dnrrsrgivq ekgdavkdts rqkkqqqqqq qqsqpqpqpq sqsqsqsqsq 181 sqqrgptvqv ssdhliqdmn lsrvssssqa setsndadde ddedeeyidl tllqqgqyha 241 pgyntllppq destkgkkcl ildldetlvh ssfkylrsad fvlsveiddq vhnvyvikrp 301 gveeflervg klfevvvfta svsrygdpll dildtdkvih hrlfreacyn yegnyiknls 361 qigrplsdii ildnspasyi fhpqhaipis swfsdthdne lldiiplled lsvktsldvg 421 kildvti // LOCUS NP_013092 69 aa linear PLN 30-JUN-2025 DEFINITION copper metallochaperone COX17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013092 VERSION NP_013092.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181829.1 REFERENCE 1 (residues 1 to 69) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 69) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 69) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 69) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09309. Method: conceptual translation. FEATURES Location/Qualifiers source 1..69 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..69 /product="copper metallochaperone COX17" /calculated_mol_wt="7925" Region 18..65 /region_name="COX17" /note="Cytochrome C oxidase copper chaperone (COX17); pfam05051" /db_xref="CDD:428283" CDS 1..69 /gene="COX17" /locus_tag="YLL009C" /coded_by="NM_001181829.1:1..210" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:9407107]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9407107]" /experiment="EXISTENCE:direct assay:GO:0006825 copper ion transport [PMID:15199057]" /experiment="EXISTENCE:direct assay:GO:0016531 copper chaperone activity [PMID:15199057]" /experiment="EXISTENCE:direct assay:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:15199057]" /experiment="EXISTENCE:mutant phenotype:GO:0016531 copper chaperone activity [PMID:9585572]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:8662933]" /note="Copper metallochaperone that transfers copper to Sco1p and Cox11p; eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs; interacts with the MICOS complex, and interaction is promoted by copper ions; human homolog COX17 partially complements yeast null mutant" /db_xref="GeneID:850651" /db_xref="SGD:S000003932" ORIGIN 1 mtetdkkqeq enhaecedkp kpccvckpek eerdtcilfn gqdsekckef iekykecmkg 61 ygfevpsan // LOCUS NP_013093 752 aa linear PLN 30-JUN-2025 DEFINITION putative ATP-dependent RNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013093 VERSION NP_013093.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181828.1 REFERENCE 1 (residues 1 to 752) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 752) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 752) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 752) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 752) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09310. Method: conceptual translation. FEATURES Location/Qualifiers source 1..752 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..752 /product="putative ATP-dependent RNA helicase" /EC_number="3.6.4.13" /calculated_mol_wt="84712" Region 232..674 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..752 /gene="DRS1" /locus_tag="YLL008W" /coded_by="NM_001181828.1:1..2259" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:1454790]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:1454790]" /note="Nucleolar DEAD-box protein required for ribosome assembly and function; including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles" /db_xref="GeneID:850652" /db_xref="SGD:S000003931" ORIGIN 1 mvvgtkkysn ldfvptisds eddvpildss ddekveakkt tkkrkgknnk kkvsegdnld 61 edvhedldag fkfdldaddt tsnfqgwnfl aegesnkdda eafvkkdvdl dkiirrkggl 121 vkmahidskq eeetekekve kendsddeel amdgfgmgap mnngdenqse eeeeeeekee 181 eeeeeeeqee mtlekggkdd eideeddsee akadfyapet egdeakkqmy enfnslslsr 241 pvlkglaslg yvkpspiqsa tipiallgkd iiagavtgsg ktaafmipii erllykpaki 301 astrvivllp trelaiqvad vgkqiarfvs gitfglavgg lnlrqqeqml ksrpdiviat 361 pgrfidhirn sasfnvdsve ilvmdeadrm leegfqdeln eimgllpsnr qnllfsatmn 421 skikslvsls lkkpvrimid ppkkaatklt qefvrirkrd hlkpallfnl irkldptgqk 481 rivvfvarke tahrlriimg llgmsvgelh gsltqeqrld svnkfknlev pvlictdlas 541 rgldipkiev vinydmpksy eiylhrvgrt aragregrsv tfvgessqdr sivraaiksv 601 eenksltqgk algrnvdwvq ieetnklves mndtiedilv eekeekeilr aemqlrkgen 661 mlkhkkeiqa rprrtwfqse sdkknskvlg alsrnkkvtn skkrkreeak adgngarsyr 721 ktktdriadq ertfkkqkst nsnkkkgfks rr // LOCUS NP_013094 665 aa linear PLN 30-JUN-2025 DEFINITION Lmo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013094 VERSION NP_013094.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181827.1 REFERENCE 1 (residues 1 to 665) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 665) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 665) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 665) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 665) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 665) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 665) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 665) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 665) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09311. Method: conceptual translation. FEATURES Location/Qualifiers source 1..665 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..665 /product="Lmo1p" /calculated_mol_wt="76491" Region 450..594 /region_name="PH_12" /note="Pleckstrin homology domain; pfam16457" /db_xref="CDD:465123" CDS 1..665 /gene="LMO1" /locus_tag="YLL007C" /coded_by="NM_001181827.1:1..1998" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25598154]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25598154]" /experiment="EXISTENCE:genetic interaction:GO:0035556 intracellular signal transduction [PMID:25598154]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:25598154]" /experiment="EXISTENCE:mutant phenotype:GO:0035556 intracellular signal transduction [PMID:25598154]" /note="Homolog of mammalian ELMO (Engulfment and celL MOtility); upstream component for regulation through the small GTPase Rho5p; may form a complex with Dck1p that acts as a GEF for Rho5p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein" /db_xref="GeneID:850653" /db_xref="SGD:S000003930" ORIGIN 1 mkhnrqmpde slenikvlln pklgkpvksl tsaqskacyh tlisnknlnk tsdeyeklla 61 nyillcdeky lcktvipdsr fwailcdncq klrsetlvan lirifnvalk cqdsnknevi 121 vsichisren sqligillql lsqrpihipl ftdtilcitl flkcsltlce tslshavefv 181 prilillfqy nfpasmsell yiedlqplil eefvplkqrl inflssvsid dyscslkadl 241 ltaikdnsvf qkglememgd lpsinllnay dtftflnspn gsfkrlyteq llfgendfpl 301 yeaifklsdq frrlfnlsgk kenqysdser dlklqiatav lnrqtcfykt lelflrfwie 361 slaksqsdlv sllnlaiitl kyvclsssdl eaaiqtksll ktqvvaldsm rykfartlql 421 dsikkeqyrt wsssiasfdt mlsgqvrdyv rhqrllqlqk gtwvyaenpl npeagtpkvy 481 flivsdnhan llarefetqt ndlpylfdnk iltspgseal angrtkvvvl khitsfksie 541 lttpsrrtss nvyikldean vytgvelkdr ndrtvlkfyl dteegryiwl dglklispfq 601 hedisedtke qidtlfdlrk nvqminlnvr qdiivpppep sdededeefy nletlkkvtq 661 nfyfd // LOCUS NP_878116 58 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLL006W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878116 VERSION NP_878116.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184559.1 REFERENCE 1 (residues 1 to 58) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 58) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 58) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 58) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 58) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09312. Method: conceptual translation. FEATURES Location/Qualifiers source 1..58 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..58 /product="uncharacterized protein" /calculated_mol_wt="6621" CDS 1..58 /locus_tag="YLL006W-A" /coded_by="NM_001184559.1:1..177" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466403" /db_xref="SGD:S000028560" ORIGIN 1 mtqlsqsnve rvalvyisvy ffscislivy fftfclsvsi pknrqhpiki iynnkcps // LOCUS NP_013095 426 aa linear PLN 30-JUN-2025 DEFINITION ERMES complex subunit MMM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013095 VERSION NP_013095.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181826.1 REFERENCE 1 (residues 1 to 426) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 426) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 426) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 426) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09313. Method: conceptual translation. FEATURES Location/Qualifiers source 1..426 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..426 /product="ERMES complex subunit MMM1" /calculated_mol_wt="48529" Region 95..418 /region_name="MMM1" /note="Maintenance of mitochondrial morphology protein 1; pfam10296" /db_xref="CDD:431202" CDS 1..426 /gene="MMM1" /locus_tag="YLL006W" /gene_synonym="YME6" /coded_by="NM_001181826.1:1..1281" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:11266455|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:19556461]" /experiment="EXISTENCE:direct assay:GO:0032865 ERMES complex [PMID:19556461|PMID:17410204]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:37366411]" /experiment="EXISTENCE:direct assay:GO:0120013 lipid transfer activity [PMID:29279306]" /experiment="EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:19556461]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:11266455]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:8089172]" /experiment="EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:19556461]" /experiment="EXISTENCE:mutant phenotype:GO:0015917 aminophospholipid transport [PMID:27469264]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:17410204]" /experiment="EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:17410204]" /experiment="EXISTENCE:mutant phenotype:GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering [PMID:19556461]" /experiment="EXISTENCE:physical interaction:GO:0032865 ERMES complex [PMID:13679517]" /note="ER integral membrane protein, ERMES complex subunit; ERMES links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; required for mitophagy; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase; localizes to the peroxisome in glucose" /db_xref="GeneID:850654" /db_xref="SGD:S000003929" ORIGIN 1 mtdseneste tdslmtfddy iskelpehlq rlimenlkgs ttndlkqtsn nsefnvskng 61 sfkglddaiq alqmqsvlhp sslgslatss kfsgwsfaqg ffvgqlsivl lfifflkffi 121 fsdepskskn pkpaasrhrs kfkeypfisr efltslvrkg akqhyelnee aenehlqela 181 lilektyynv dvhpaesldw fnvlvaqiiq qfrseawhrd nilhslndfi grkspdlpey 241 ldtikiteld tgddfpifsn criqyspnsg nkkleakidi dlndhltlgv etklllnypk 301 pgiaalpinl vvsivrfqac ltvsltnaee fastsngsss engmegnsgy flmfsfspey 361 rmefeiksli gsrsklenip kigsvieyqi kkwfvercve prfqfvrlps mwprskntre 421 ekptel // LOCUS NP_013096 868 aa linear PLN 30-JUN-2025 DEFINITION Spo75p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013096 VERSION NP_013096.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181825.1 REFERENCE 1 (residues 1 to 868) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 868) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 868) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 868) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09314. Method: conceptual translation. FEATURES Location/Qualifiers source 1..868 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..868 /product="Spo75p" /calculated_mol_wt="102039" Region 1..868 /region_name="COG5594" /note="Uncharacterized integral membrane protein [Function unknown]" /db_xref="CDD:227881" CDS 1..868 /gene="SPO75" /locus_tag="YLL005C" /coded_by="NM_001181825.1:1..2607" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]" /note="Meiosis-specific hypothetical protein; required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis" /db_xref="GeneID:850655" /db_xref="SGD:S000003928" ORIGIN 1 mnatkeltfn llnkfqdker fgsaqrhagi slkgfisgil fsflyflfql slfiilrsrf 61 ktiyqanvvl kihpgskvcf akkkiknyws lfaflkqlpg rmldpmekfe rnerygldny 121 lflrflklli fffavlsiin ipilipihyf srdilkeneg eryeqsfrtt skldkwtmsn 181 lspnssntli chlflsifvv lwfhfilsse lrfvnrlgys vltkskyqni lylegfsskl 241 vtqsisletf fqplhsdcfg vthfipknlk kvhkleikln klqkskeqii feiilekyfr 301 rvsihrhlia nhkrfffskl knhllfqykk lvfltqfris yyctkirlrw kkssifplyy 361 pklyvnteti lerkyrildk iirkeklikf qvnslkatse tkqalpddls sgtdiymdkm 421 fitfkstlls nvigellsyr lptqnlkvii gpnvndiiwr nildssplwk sakyfsanil 481 rifviigwil pvaflglisq ipnisslipf tkiihfqspf irevaknlip ivtliiiiei 541 vpyffrwlsy lrglktgaqi eadvqnwyfv fvfihlfvvv tissgfsiii erllnnpvsi 601 pallandlpk canffcsfvl irgmayaggn llrikellfe lfyykwkrst phaqfkrlkt 661 slffqlgsiy pifsvlgcig iiysvvapii lllccisfsm vffsfsylfk yqynkenyse 721 tfgklyiqal mqlyagiyfm efcllglftl fdqytlstim lvvfaltvit hskiskqiks 781 kpqriptley lsnlteerkd qfcqesytfh difsicrnsd eiwlprdklg iseeeqsfle 841 ksyhlkfdln mysmnlfgdc hlenshlh // LOCUS NP_013097 616 aa linear PLN 30-JUN-2025 DEFINITION origin recognition complex subunit 3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013097 VERSION NP_013097.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181824.1 REFERENCE 1 (residues 1 to 616) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 616) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 616) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 616) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09315. Method: conceptual translation. FEATURES Location/Qualifiers source 1..616 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..616 /product="origin recognition complex subunit 3" /calculated_mol_wt="71946" Region 57..613 /region_name="Orc3" /note="Origin recognition complex subunit 3; cd20704" /db_xref="CDD:412052" Site order(58,61..62,65,135,144..145,148,309,315,319,323,326, 330,477..479,483..484,486..488,490..491,494,497,519,521, 529..533,536..539,578..579,581..583,585..586,588..589, 592..596,599,606..607,609..613) /site_type="other" /note="Orc2 interface [polypeptide binding]" /db_xref="CDD:412052" Site order(106,140,143,209..210,222,225,230,242..244,246,248, 253,256..257,263,305,307..308,479,484..485,598,611,613) /site_type="other" /note="Orc5 interface [polypeptide binding]" /db_xref="CDD:412052" Site order(134,140..141,144..145,601..602) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:412052" Site order(138,249,252..253,257) /site_type="other" /note="Orc4 interface [polypeptide binding]" /db_xref="CDD:412052" Site order(144,148,175) /site_type="other" /note="Orc1 interface [polypeptide binding]" /db_xref="CDD:412052" Site order(327,330,464,469,474,490,492,494..497,526,529) /site_type="other" /note="Orc6 interface [polypeptide binding]" /db_xref="CDD:412052" CDS 1..616 /gene="ORC3" /locus_tag="YLL004W" /coded_by="NM_001181824.1:1..1851" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10783164|PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]" /experiment="EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16716188]" /note="Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" /db_xref="GeneID:850656" /db_xref="SGD:S000003927" ORIGIN 1 msdlnqskkm nvsefadaqr shytvypslp qsnkndkhip fvkllsgkes evnvekrwel 61 yhqlhshfhd qvdhiidnie adlkaeisdl lysettqkrr cfntifllgs dsttkielkd 121 essrynvlie ltpkespnvr mmlrrsmykl ysaadaeehp tikyedinde dgdfteqnnd 181 vsydlslven fkrlfgkdla mvfnfkdvds infntldnfi illksafkyd hvkislifni 241 ntnlsniekn lrqstirllk rnyhkldvss nkgfkygnqi fqsfldtvdg klnlsdrfve 301 filskmannt nhnlqlltkm ldyslmsyff qnafsvfidp vnvdflnddy lkilsrcptf 361 mffveglikq hapadeilsl ltnknrglee ffveflvren pinghakfva rfleeelnit 421 nfnlielyhn lligkldsyl drwsackeyk drlhfepidt ifqelftldn rsglltqsif 481 psyksniedn llsweqvlps ldkenydtls gdldkimapv lgqlfklyre anmtiniydf 541 yiafretlpk eeilnfirkd psntkllela etpdafdkva lilfmqaifa fenmglikfq 601 stksydlvek cvwrgi // LOCUS NP_013098 946 aa linear PLN 30-JUN-2025 DEFINITION Sfi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013098 VERSION NP_013098.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181823.1 REFERENCE 1 (residues 1 to 946) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 946) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 946) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 946) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 946) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09316. Method: conceptual translation. FEATURES Location/Qualifiers source 1..946 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..946 /product="Sfi1p" /calculated_mol_wt="112848" Region 218..306 /region_name="Sfi1p_helix" /note="Helix located at the middle N-terminal region of Sfi1p; cd23506" /db_xref="CDD:439387" Site order(218,221..222,224,229,232..234,236..241,244..245, 247..248,252,255,258..260,262..271,274..275,278,281..283, 285..287,289..290,292..294) /site_type="other" /note="centrin binding site [polypeptide binding]" /db_xref="CDD:439387" Region 259..794 /region_name="Sfi1" /note="Sfi1 spindle body protein; pfam08457" /db_xref="CDD:430007" Region 812..913 /region_name="Sfi1_C" /note="Spindle body associated protein C-terminus; pfam10638" /db_xref="CDD:402327" CDS 1..946 /gene="SFI1" /locus_tag="YLL003W" /coded_by="NM_001181823.1:1..2841" /experiment="EXISTENCE:direct assay:GO:0005825 half bridge of spindle pole body [PMID:14504268]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10455233]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:14504268]" /experiment="EXISTENCE:mutant phenotype:GO:0051225 spindle assembly [PMID:17392514]" /note="Centrin (Cdc31p)-binding protein required for SPB duplication; localizes to the half-bridge of the spindle pole body (SPB); required for progression through G(2)-M transition; phosphorylated by Cdc28p-Clb2p and by Cdc5p; dephosphorylated by Cdc14p; has similarity to Xenopus laevis XCAP-C" /db_xref="GeneID:850657" /db_xref="SGD:S000003926" ORIGIN 1 mgkfgttnks tenllrdkfv petsptnipt dvlikqgqit dsteslihgg aeryivnalk 61 pielnktegf fedppfhlps ppvdstnley edvtdlpkng lrydlndisv eviedlyrqi 121 eaflvhfkls rsflqifkny vniliqegin plrdeyftil edelkgfftf nsvieeilei 181 flihprnkfi alslaeytya knkirrhfnh wktvcelnee anrfanqakl rvqeavfyiw 241 sdktlkysqm andeaesfrn twllfrsfqq witltqtlke qsrladqafl nkmfrkilka 301 qehwkhletv ntdnikkifl rttfhiwklr hkeinyhgle rriferikqk vinyeynksi 361 aekvrsfslq rkylnkwekk nienedklga lyelenkfik qkffrklnrs fqhsqqeaia 421 ksklnqtllr cvfekmwlkr fedhlhlysi vslkeanlvk rifhswkkll yidlkasdys 481 rtnllksslr swklevklki feqkckksiq asayrtwrkr iqygkisseh vktafcakyl 541 gvwkrrmlqm nsmndeaskf yeeglvnecl aiwkerlikt keledrynfl ckthailtvk 601 rtlmhidnvh llytklapsm drvklskafl kwrkatrfkv rhklndilhv yekskerelq 661 sqlfnawrnr fcfyteecni qaiskrnyql ekmvlkkfre rlleivksee ladevreefv 721 lvktfyiwkt hldeifymst lleqseankq fiitskflkm wslrflkikr ndetvevfrh 781 rwdratvrgl lllwknrsds spkrrkdfnl khelktpirs dsqnastipg serikqhrme 841 amkshysrar raipspvkss svldstakkq inlesttgln gsptrgkplr ysprrttrnm 901 pskvdhidfg ripavpfsls anspkidqdm dyirehdksp lsrkrq // LOCUS NP_013099 436 aa linear PLN 30-JUN-2025 DEFINITION H3 histone acetyltransferase RTT109 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013099 VERSION NP_013099.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181822.1 REFERENCE 1 (residues 1 to 436) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 436) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 436) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 436) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09317. Method: conceptual translation. FEATURES Location/Qualifiers source 1..436 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..436 /product="H3 histone acetyltransferase RTT109" /EC_number="2.3.1.48" /calculated_mol_wt="49965" Region 3..432 /region_name="RTT109" /note="Uncharacterized conserved protein [Function unknown]; COG5087" /db_xref="CDD:227419" CDS 1..436 /gene="RTT109" /locus_tag="YLL002W" /gene_synonym="KAT11; KIM2; REM50" /coded_by="NM_001181822.1:1..1311" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0010484 histone H3 acetyltransferase activity [PMID:17272723|PMID:17272722]" /experiment="EXISTENCE:genetic interaction:GO:0010484 histone H3 acetyltransferase activity [PMID:18458063]" /experiment="EXISTENCE:genetic interaction:GO:0043007 maintenance of rDNA [PMID:23593017]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19620280]" /experiment="EXISTENCE:mutant phenotype:GO:0010468 regulation of gene expression [PMID:26941319]" /experiment="EXISTENCE:mutant phenotype:GO:0010484 histone H3 acetyltransferase activity [PMID:18458063|PMID:17046836|PMID:17272723|PMID:17272722]" /experiment="EXISTENCE:mutant phenotype:GO:0010526 transposable element silencing [PMID:11779788]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:19620280]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /experiment="EXISTENCE:mutant phenotype:GO:2001032 regulation of double-strand break repair via nonhomologous end joining [PMID:27222517|PMID:18036332]" /note="Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p" /db_xref="GeneID:850658" /db_xref="SGD:S000003925" ORIGIN 1 mslndflssv lpvseqfeyl slqsipleth avvtpnkddk rvpkstiktq hffslfhqgk 61 vffslevyvy vtlwdeadae rlifvskadt ngycntrvsv rditkiilef ilsidpnyyl 121 qkvkpairsy kkispelisa astpartlri larrlkqsgs tvlkeiespr fqqdlylsft 181 cpreiltkic lftrpasqyl fpdssknskk hilngeelmk wwgfildrll iecfqndtqa 241 klripgedpa rvrsylrgmk yplwqvgdif tskenslavy niplfpddpk arfihqlaee 301 drllkvslss fwielqerqe fklsvtssvm gisgyslatp slfpssadvi vpksrkqfra 361 ikkyitgeey dteegaieaf tnirdflllr matnlqsltg krehrernqp vpasnintla 421 itmlkprkka kalpkt // LOCUS NP_013100 757 aa linear PLN 30-JUN-2025 DEFINITION dynamin-related GTPase DNM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013100 VERSION NP_013100.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181821.1 REFERENCE 1 (residues 1 to 757) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 757) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 757) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 757) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 757) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 757) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 757) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 757) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 757) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09318. Method: conceptual translation. FEATURES Location/Qualifiers source 1..757 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..757 /product="dynamin-related GTPase DNM1" /EC_number="3.6.5.5" /calculated_mol_wt="84841" Region 26..333 /region_name="DLP_1" /note="Dynamin_like protein family includes dynamins and Mx proteins; cd08771" /db_xref="CDD:206738" Site 35..42 /site_type="other" /note="G1 box" /db_xref="CDD:206738" Site order(36,38..43,56..57,62,175,245,247..248,274..278,281) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206738" Site order(37..38,179,192,217,219,221..224,226..227,248, 250..253,277..279) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:206738" Site 62 /site_type="other" /note="G2 box" /db_xref="CDD:206738" Site 66..68 /site_type="other" /note="Switch I region" /db_xref="CDD:206738" Site 175..178 /site_type="other" /note="G3 box" /db_xref="CDD:206738" Site order(177..178,208..209) /site_type="other" /note="Switch II region" /db_xref="CDD:206738" Site 244..247 /site_type="other" /note="G4 box" /db_xref="CDD:206738" Region 254..540 /region_name="Dynamin_M" /note="Dynamin central region; pfam01031" /db_xref="CDD:460033" Site 274..276 /site_type="other" /note="G5 box" /db_xref="CDD:206738" Region 665..756 /region_name="GED" /note="Dynamin GTPase effector domain; smart00302" /db_xref="CDD:128597" CDS 1..757 /gene="DNM1" /locus_tag="YLL001W" /gene_synonym="DRP1" /coded_by="NM_001181821.1:1..2274" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16186251|PMID:11553714]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:10559943|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:11038182]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:16968746]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16272155]" /experiment="EXISTENCE:direct assay:GO:0042802 identical protein binding [PMID:16186251]" /experiment="EXISTENCE:direct assay:GO:0090149 mitochondrial membrane fission [PMID:29202017]" /experiment="EXISTENCE:direct assay:GO:0097753 membrane bending [PMID:29202017]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:23341591|PMID:17336903]" /experiment="EXISTENCE:genetic interaction:GO:0000266 mitochondrial fission [PMID:10559943]" /experiment="EXISTENCE:genetic interaction:GO:0007031 peroxisome organization [PMID:16968746]" /experiment="EXISTENCE:genetic interaction:GO:0016559 peroxisome fission [PMID:18445678]" /experiment="EXISTENCE:genetic interaction:GO:0044804 nucleophagy [PMID:39920277]" /experiment="EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:23341591]" /experiment="EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:10559943]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:16272155]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:9786946]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:16968746]" /experiment="EXISTENCE:mutant phenotype:GO:0015886 heme transport [PMID:32265272]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:39920277]" /experiment="EXISTENCE:mutant phenotype:GO:0090148 membrane fission [PMID:39920277]" /note="Dynamin-related GTPase involved in mitochondrial organization; required for mitochondrial fission and inheritance; self assembles on mitochondrial tubules at incipient division sites; involved in endocytosis; regulates peroxisome fission with Vps1p; role in nuclear envelope remodeling during nucleophagy; mutants in human ortholog DNM1L, which mediates mitochondrial fission, peroxisomal division, autophagy, and mitophagy, are associated with slowly progressive infantile encephalopathy" /db_xref="GeneID:850686" /db_xref="SGD:S000003924" ORIGIN 1 masledlipt vnklqdvmyd sgidtldlpi lavvgsqssg kssiletlvg rdflprgtgi 61 vtrrplvlql nnispnspli eeddnsvnph devtkisgfe agtkpleyrg kernhadewg 121 eflhipgkrf ydfddikrei enetariagk dkgiskipin lkvfsphvln ltlvdlpgit 181 kvpigeqppd iekqiknlil dyiatpncli lavspanvdl vnseslklar evdpqgkrti 241 gvitkldlmd sgtnaldils gkmyplklgf vgvvnrsqqd iqlnktvees ldkeedyfrk 301 hpvyrtistk cgtrylakll nqtllshird klpdiktkln tlisqteqel aryggvgatt 361 nesraslvlq lmnkfstnfi ssidgtssdi ntkelcggar iyyiynnvfg nslksidpts 421 nlsvldvrta irnstgprpt lfvpelafdl lvkpqiklll epsqrcvelv yeelmkichk 481 cgsaelaryp klksmlievi sellrerlqp trsyveslid ihrayintnh pnflsateam 541 ddimktrrkr nqellkskls qqengqtngi ngtssissni dqdsaknsdy dddgidaesk 601 qtkdkflnyf fgkdkkgqpv fdasdkkrsi agdgniedfr nlqisdfslg diddlenaep 661 pltereelec elikrlivsy fdiiremied qvpkavmcll vnyckdsvqn rlvtklyket 721 lfeellvedq tlaqdrelcv kslgvykkaa tlisnil // LOCUS NP_013101 862 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR001C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013101 VERSION NP_013101.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181888.1 REFERENCE 1 (residues 1 to 862) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 862) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 862) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 862) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09319. Method: conceptual translation. FEATURES Location/Qualifiers source 1..862 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..862 /product="uncharacterized protein" /calculated_mol_wt="97488" Region 36..>79 /region_name="FAS1" /note="Uncaracterized surface protein containing fasciclin (FAS1) repeats [General function prediction only]; COG2335" /db_xref="CDD:441906" Region 46..163 /region_name="Fasciclin" /note="Fasciclin domain; cl02663" /db_xref="CDD:470649" Region 493..603 /region_name="Fasciclin" /note="Fasciclin domain; cl02663" /db_xref="CDD:470649" CDS 1..862 /locus_tag="YLR001C" /coded_by="NM_001181888.1:1..2589" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated" /db_xref="GeneID:850687" /db_xref="SGD:S000003991" ORIGIN 1 mnmaiqtiky ifwllpilgl tqallqnpgd dfpfstvidi lsenvefstf lriiqktghv 61 qylnelqnft lfapinsafi kgdqttdqfe ehfhiedfli hdrvlqvrdl engtylekra 121 akaplllrkh erhcfvneia vvepdllpsf qnaslqginn llliqpqine llvqldeetq 181 dlkifsdfis sfsnynaytn sstvlvpldv nfrkffntie inylldkynk lgksntisqa 241 kwaadrtsll qeliiddvyg gilpkelile nknnrklfmk snsegtsvsv nnsdyspisn 301 rifeigvvhg fsdldflrth iqfdaekylh glncsefvke lyfrdlekfi qngrkitifv 361 pqasfnedrg ytkpsllyhf vegkidleqd fsslrpiqya ptqiydsafc ssakrlgghc 421 qkfkitrsnk gyyingrfki lntkpyeign tsiysidddl qlpgdlvlsl apenhcsisl 481 mllkelnlld lpsnhkgyti llpcmnswdn ndltidylrs nktalnllmr nlifedliys 541 nnysisttvk nlygnsvsig vqkivgsqnl tkisvstike siiieessdi ffnqgvihpi 601 dqldfpvdle islkeliett gtkeifdffn lfydlssiiw nneeysllvp tassiplsgi 661 tanstnlrkf lelhlipanv tqnlldcngs istklgtkln crkdhldnvf vsiqgdwtke 721 vrvlktgctt nlksscifli dkpislswln sekyhlrlpg iavgfgviig vtiaisllfc 781 iiitrggkvk dknqrgrndr attpliqhsp iihnpsysat ahlsplsqpt fegsysvnai 841 qtprdirrvg sdqkggrsvs ts // LOCUS NP_013102 663 aa linear PLN 30-JUN-2025 DEFINITION Noc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013102 VERSION NP_013102.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181889.1 REFERENCE 1 (residues 1 to 663) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 663) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 663) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 663) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09320. Method: conceptual translation. FEATURES Location/Qualifiers source 1..663 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..663 /product="Noc3p" /calculated_mol_wt="75451" Region 1..660 /region_name="NOC3" /note="Protein involved in the nuclear export of pre-ribosomes [Translation, ribosomal structure and biogenesis / Intracellular trafficking and secretion]; COG5117" /db_xref="CDD:227447" CDS 1..663 /gene="NOC3" /locus_tag="YLR002C" /coded_by="NM_001181889.1:1..1992" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12110182]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12110182]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:11371346]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:22421151]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11371346]" /experiment="EXISTENCE:direct assay:GO:0006270 DNA replication initiation [PMID:12110182]" /experiment="EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:12110182]" /experiment="EXISTENCE:direct assay:GO:0030691 Noc2p-Noc3p complex [PMID:11371346]" /experiment="EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:22421151]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11371346]" /note="Subunit of a nuclear complex with Noc2p and pre-replicative complexes; the Noc2p-Noc3p complex binds to 66S ribosomal precursors to mediate their maturation and intranuclear transport; binds to chromatin at active replication origins, and is required for pre-RC formation and maintenance during DNA replication licensing" /db_xref="GeneID:850688" /db_xref="SGD:S000003992" ORIGIN 1 makrnrsqfr iqertakkrk hedsllegnv fqnapedmde ntiysakgss wdeeeqdyem 61 vprknrsdts nlveglpikv ngkverklhk aqekpkddde ededsndsse ddegpneeqe 121 aeakedepdt eekilqlked iadlvtkvme epeentaalg rlckmveskn pntckfsmla 181 lvpvfksiip gyrirpltet ekkekvskev sklrnfeqal vynyknyvgr lqslsktpsn 241 aapiqvslgi latqaakeli stashfnfrt diftlllrri ckpristdpt siqiiqtfet 301 llnedeegsi sfeilrifnk ilktrnfnie esvlnmllsl dvlhdydpnt klkgnvsapk 361 lkkkdrvhls kkqrkarkem qqieeemrna eqavsaeere rnqseilkiv ftiylnilkn 421 naktligsvl egltkfgnma nfdllgdfle vmkelisdte fdnlssaevr kallcivsaf 481 slisntqymk vnvdlskfvd glyallpyic ldadielsyr slrladplnn eiikpsvnvs 541 tkaelllkal dhvffrsksg tkerataftk rlymcishtp ektsiailkf idklmnrype 601 isglyssedr ignghfimea dnpsrsnpea atlwdnalle khycpvvtkg lrslssrske 661 csk // LOCUS NP_013103 291 aa linear PLN 30-JUN-2025 DEFINITION Cms1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013103 VERSION NP_013103.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181890.1 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09321. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..291 /product="Cms1p" /calculated_mol_wt="33263" Region <102..264 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" CDS 1..291 /gene="CMS1" /locus_tag="YLR003C" /coded_by="NM_001181890.1:1..876" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /note="Putative subunit of the 90S preribosome processome complex; overexpression rescues supressor mutant of mcm10; null mutant is viable; relocalizes from nucleus to cytoplasm upon DNA replication stress" /db_xref="GeneID:850689" /db_xref="SGD:S000003993" ORIGIN 1 msnpddlddg laydfdaehe vifdakdgsp ptkkvqkrsi eqddddvddi dgkkeernse 61 ddsnrpiskr qkklqkkskl iekkkeesqy ivsqrkalpa sspekiieyl ttlireknpd 121 lsvleleely fkrndflste kfdaerrlsn fpafiqkfsv apkkivfsms nirvadvyrs 181 lnggkncvkl fsksklkddi atverlltds skksnknkds lyfiatptrm qkiieatdll 241 fqgkekldii ldasyldpkd ntilsfenaa vlcqvlktfl nkkssvkill y // LOCUS NP_013104 523 aa linear PLN 30-JUN-2025 DEFINITION Thi73p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013104 VERSION NP_013104.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181891.1 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09322. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..523 /product="Thi73p" /calculated_mol_wt="58401" Region 77..481 /region_name="MFS_FEN2_like" /note="Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; cd17327" /db_xref="CDD:340885" Site order(93..94,97..98,101,132,182..183,185..187,190,210, 213..214,217,316,319..320,323..325,328,355,359,411..412, 416,420,436,439..440,443..444,447) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340885" CDS 1..523 /gene="THI73" /locus_tag="YLR004C" /coded_by="NM_001181891.1:1..1572" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16850348]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Putative plasma membrane permease; proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs" /db_xref="GeneID:850690" /db_xref="SGD:S000003994" ORIGIN 1 mknmsqrsmd vekkaanads csvstssinv ddadvalrfl kqngldesst aneddvvage 61 eanfygshel spkvlrkvdl filpflccty llmfldkall nyaasmgikd hlkgnefsnl 121 gtifsaayif mepvvtyliq kfpiskilgt fitvwgivla chaacktyas lmvvrtllgl 181 fesssavgci aisgmyytks eqsarigfwa tqagtgyivg glisfgflhy hgtaftswqi 241 mflvvglvtv afgvltflyl pdnvtnawfl nkeekiqvve hiranqtgle tkkfkkqqvk 301 elflhdkftw pmllltacsq istgaigtfs vtitgtfgfd kyetallqlp igaitamiil 361 ittqmlsrwg hitlittsmy ipaiigcivl islplshkig nlfslyllys gscvitniyi 421 wnscntsgyt krvfrnaitm ivynvsciia pqmfraysap ryipakiall vtqcvcvplq 481 lyigyickke nekrdkeqeg qerkkyqfld ltdienrnfr yiy // LOCUS NP_013105 461 aa linear PLN 30-JUN-2025 DEFINITION TFIIH/NER complex subunit SSL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013105 VERSION NP_013105.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181892.1 REFERENCE 1 (residues 1 to 461) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 461) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 461) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 461) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09323. Method: conceptual translation. FEATURES Location/Qualifiers source 1..461 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..461 /product="TFIIH/NER complex subunit SSL1" /calculated_mol_wt="52159" Region 21..459 /region_name="SSL1" /note="RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]; COG5151" /db_xref="CDD:227480" CDS 1..461 /gene="SSL1" /locus_tag="YLR005W" /coded_by="NM_001181892.1:1..1386" /experiment="EXISTENCE:direct assay:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:8855246]" /experiment="EXISTENCE:direct assay:GO:0000439 transcription factor TFIIH core complex [PMID:14500720|PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:15837426]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:7891722]" /note="Subunit of the core form of RNA polymerase transcription factor TFIIH; has both protein kinase and DNA-dependent ATPase/helicase activities; essential for transcription and nucleotide excision repair; interacts with Tfb4p" /db_xref="GeneID:850691" /db_xref="SGD:S000003995" ORIGIN 1 mapvvisese ededrvaitr rtkrqvhfdg egddrvdqqq qqhssshrdr dkhvqrkkkk 61 rlsnrnlqgs nggyawedei krswdlvkvd degdmaslva sivearkkrt akknitpyqr 121 giirsliltl dcseamlekd lrpnrhamii qyaidfvhef fdqnpisqmg iiimrnglaq 181 lvsqvsgnpq dhidalksir kqepkgnpsl qnalemargl llpvpahctr evlivfgsls 241 ttdpgdihqt idslvsekir vkvlglsaqv aickelckat nygdesfyki lldethlkel 301 fneavtplpv nkinkgftlv kmgfptrife dtptfcschs klvyggyfcp nchskvcslp 361 tvcpccdlml ilsthlarsy hhlmplktfa evpttekfrs edcfscqsrf pilknhkngk 421 lltssryrce dckqefcvdc dvfiheilhn cpgceskpvi t // LOCUS NP_013106 712 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase kinase kinase SSK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013106 VERSION NP_013106.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181893.1 REFERENCE 1 (residues 1 to 712) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 712) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 712) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 712) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 712) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09324. Method: conceptual translation. FEATURES Location/Qualifiers source 1..712 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..712 /product="mitogen-activated protein kinase kinase kinase SSK1" /calculated_mol_wt="78398" Region 506..643 /region_name="REC_hyHK_CKI1_RcsC-like" /note="phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; cd17546" /db_xref="CDD:381099" Site order(512,514..515,517..518,521..522,525,611,633,635..636) /site_type="other" /note="Hpt domain binding site [polypeptide binding]" /db_xref="CDD:381099" CDS 1..712 /gene="SSK1" /locus_tag="YLR006C" /coded_by="NM_001181893.1:1..2139" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14665464]" /experiment="EXISTENCE:direct assay:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:8808622]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:9482735]" /experiment="EXISTENCE:direct assay:GO:0071474 cellular hyperosmotic response [PMID:9482735]" /experiment="EXISTENCE:direct assay:GO:1900744 regulation of p38MAPK cascade [PMID:9482735]" /experiment="EXISTENCE:genetic interaction:GO:1900744 regulation of p38MAPK cascade [PMID:9482735]" /experiment="EXISTENCE:mutant phenotype:GO:0000156 phosphorelay response regulator activity [PMID:8183345]" /experiment="EXISTENCE:mutant phenotype:GO:0030295 protein kinase activator activity [PMID:9482735]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:19633059]" /experiment="EXISTENCE:mutant phenotype:GO:0071468 cellular response to acidic pH [PMID:19633059]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:18573873]" /experiment="EXISTENCE:mutant phenotype:GO:1900744 regulation of p38MAPK cascade [PMID:18573873]" /experiment="EXISTENCE:physical interaction:GO:0031435 mitogen-activated protein kinase kinase kinase binding [PMID:9482735]" /note="Cytoplasmic phosphorelay intermediate osmosensor and regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate" /db_xref="GeneID:850692" /db_xref="SGD:S000003996" ORIGIN 1 mlnsallwkv wlridnstde vnqpiavqfd eidtvddlks rffqklsstr wreindnasi 61 aiglyapkfd nqadntssnn tndnscrsks ngagsganls vnsntkssvs ptagsfglsk 121 dlakdrnvlq hpkptqkrga lydafaavpt vaattnvdfp pneapmlspq rpystspkqf 181 pattkspllr fasvspypkf hsdnqimasa gltyvsphnk nkytrplirk glnfttesvn 241 dctykiifep delainiyke lfgtmgsqpa sqpllifsnv nlrqdvppld ilnvvdyvpt 301 neeisqqktq ptdhgavgvf hlddhispge qglkqtigdk adlkgkdgns spqefklitd 361 eeqlrrasqe lkdeekdaes pwqailllpk gykggvdfrn kpvahtdssf nnedtithse 421 levntgspsq esgslneagi gitqpmsevq rrkedvtpas piltssqtph ysnslynapf 481 avssppdplp nlftttsekv fpkinvlive dnvinqailg sflrkhkisy klakngqeav 541 niwkegglhl ifmdlqlpvl sgieaakqir dfekqngigi qkslnnshsn lekgtskrfs 601 qapviivalt asnsqmdkrk allsgcndyl tkpvnlhwls kkitewgcmq alidfdswkq 661 gesrmtdsvl vkspqkpiap snphsfkqat smtpthspvr knsnlsptqi el // LOCUS NP_013107 336 aa linear PLN 30-JUN-2025 DEFINITION Smc5-Smc6 complex subunit NSE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013107 VERSION NP_013107.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181894.1 REFERENCE 1 (residues 1 to 336) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 336) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 336) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 336) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09325. Method: conceptual translation. FEATURES Location/Qualifiers source 1..336 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..336 /product="Smc5-Smc6 complex subunit NSE1" /EC_number="2.3.2.27" /calculated_mol_wt="38204" Region 19..257 /region_name="SMC_Nse1" /note="Nse1 non-SMC component of SMC5-6 complex; pfam07574" /db_xref="CDD:462214" Region 270..328 /region_name="RING-CH-C4HC3_NSE1" /note="RING-CH finger, H2 subclass (C4HC3-type), found in non-structural maintenance of chromosomes (SMC) element 1 homolog (NSE1) and similar proteins; cd16493" /db_xref="CDD:438156" CDS 1..336 /gene="NSE1" /locus_tag="YLR007W" /coded_by="NM_001181894.1:1..1011" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11927594]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:11927594]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]" /experiment="EXISTENCE:genetic interaction:GO:0006301 postreplication repair [PMID:17923688]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391]" /note="Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair" /db_xref="GeneID:850693" /db_xref="SGD:S000003997" ORIGIN 1 mevheeqvsa pvtgdataky llqyilsarg ichenalila lmrletdast lntewsiqqw 61 vdklndyina invklnllgy kiirinhgig rnavtlkakq nfesfednta irahnndyav 121 lqsivlpesn rffvyvnlas teetklatrf nqneiefmkw aieqfmisge tivegpalet 181 siivkevnri lvaatgdsnl akwrkfstft vgstnlfqfq eltatdiedl llrlcelkwf 241 yrtqegkfgi dlrciaelee yltsmynlnt cqnchklaiq gvrcgnescr eeneetgens 301 lsqiwhvdcf khyithvskn cdrcgsslit egvyvi // LOCUS NP_013108 168 aa linear PLN 30-JUN-2025 DEFINITION Pam18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013108 VERSION NP_013108.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181895.1 REFERENCE 1 (residues 1 to 168) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 168) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 168) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 168) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09326. Method: conceptual translation. FEATURES Location/Qualifiers source 1..168 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..168 /product="Pam18p" /calculated_mol_wt="17779" Region <103..163 /region_name="DnaJ" /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cl02542" /db_xref="CDD:413365" CDS 1..168 /gene="PAM18" /locus_tag="YLR008C" /gene_synonym="TIM14" /coded_by="NM_001181895.1:1..507" /experiment="EXISTENCE:direct assay:GO:0001405 PAM complex, Tim23 associated import motor [PMID:14638855]" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:16027163]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:14517234]" /experiment="EXISTENCE:mutant phenotype:GO:0001671 ATPase activator activity [PMID:14605210|PMID:14638855]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:14517234|PMID:14605210|PMID:14638855]" /note="Subunit of the import motor (PAM complex); the PAM complex is a component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p" /db_xref="GeneID:850694" /db_xref="SGD:S000003998" ORIGIN 1 mssqsntgns ieapqlpipg qtngsanvtv dgagvnvgiq ngsqgqktgm dlyfdqalny 61 mgehpvitgf gafltlyfta gayksiskgl nggksttafl kggfdpkmns kealqilnlt 121 entltkkklk evhrkimlan hpdkggspfl atkineakdf lekrgisk // LOCUS NP_013109 199 aa linear PLN 30-JUN-2025 DEFINITION ATPase-activating ribosome biosynthesis protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013109 VERSION NP_013109.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181896.1 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09327. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..199 /product="ATPase-activating ribosome biosynthesis protein" /calculated_mol_wt="23844" Region 2..64 /region_name="Ribosomal_L24e" /note="Ribosomal protein L24e; pfam01246" /db_xref="CDD:460131" CDS 1..199 /gene="RLP24" /locus_tag="YLR009W" /coded_by="NM_001181896.1:1..600" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:23185031]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:20670889]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:11583614|PMID:23212245]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]" /note="Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp" /db_xref="GeneID:850695" /db_xref="SGD:S000003999" ORIGIN 1 mriyqchfcs spcypghgim fvrndakefr fcrskchkaf kqrrnprklk wtkafrkaag 61 kelavdstlt faqrrnvpvr ynrelvattl kamarieeir qkrerafykn rmrgnkekdf 121 lrdkklvesn pellrireve iarklakeqe raesvseqee seeeeedmei dsdeeeeeql 181 ekqkillknr rrntkkiaf // LOCUS NP_013110 160 aa linear PLN 30-JUN-2025 DEFINITION Ten1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013110 VERSION NP_013110.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181897.1 REFERENCE 1 (residues 1 to 160) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 160) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 160) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09328. Method: conceptual translation. FEATURES Location/Qualifiers source 1..160 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..160 /product="Ten1p" /calculated_mol_wt="18473" Region 1..151 /region_name="Ten1_OBF" /note="telomere regulation protein Ten1 and similar proteins, with an oligonucleotide/oligosaccharide-binding (OB) fold; cd23707" /db_xref="CDD:467920" Site order(2..4,41,43,45,112,132,138,141..142,145,148) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467920" CDS 1..160 /gene="TEN1" /locus_tag="YLR010C" /coded_by="NM_001181897.1:1..483" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17293872]" /experiment="EXISTENCE:direct assay:GO:0061770 translation elongation factor binding [PMID:31006804]" /experiment="EXISTENCE:genetic interaction:GO:0007004 telomere maintenance via telomerase [PMID:11230140]" /experiment="EXISTENCE:genetic interaction:GO:0016233 telomere capping [PMID:11230140]" /experiment="EXISTENCE:mutant phenotype:GO:0003711 transcription elongation factor activity [PMID:31006804]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:31006804]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:11230140]" /experiment="EXISTENCE:mutant phenotype:GO:0016233 telomere capping [PMID:11230140]" /experiment="EXISTENCE:mutant phenotype:GO:0032205 negative regulation of telomere maintenance [PMID:19532124]" /experiment="EXISTENCE:physical interaction:GO:1990879 CST complex [PMID:11230140]" /note="Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p; similar to human Ten1 which is critical for the telomeric function of the CST (Cdc13p-Stn1p-Ten1p) complex" /db_xref="GeneID:850696" /db_xref="SGD:S000004000" ORIGIN 1 msqlvldlkc lkdkiatnyd ihnnvyggng mepniihpsk rfrivvrlvd flfcksdeef 61 ikgffcqmiv rnlhclnstn gaeemrlyms erlfsahkdd lrlingqvld vrigvwygih 121 qsppifeiid fkilsrndvr dfcefvkspl gekflnisns // LOCUS NP_013111 191 aa linear PLN 30-JUN-2025 DEFINITION flavin-dependent quinone reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013111 VERSION NP_013111.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181898.1 REFERENCE 1 (residues 1 to 191) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 191) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 191) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 191) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09329. Method: conceptual translation. FEATURES Location/Qualifiers source 1..191 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..191 /product="flavin-dependent quinone reductase" /EC_number="1.5.1.39" /calculated_mol_wt="21150" Region 1..159 /region_name="FMN_red" /note="NADPH-dependent FMN reductase; pfam03358" /db_xref="CDD:427259" CDS 1..191 /gene="LOT6" /locus_tag="YLR011W" /coded_by="NM_001181898.1:1..576" /experiment="EXISTENCE:direct assay:GO:0003955 NAD(P)H dehydrogenase (quinone) activity [PMID:17298444]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17298444|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:17298444]" /experiment="EXISTENCE:mutant phenotype:GO:0003955 NAD(P)H dehydrogenase (quinone) activity [PMID:17298444]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:19709309]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17298444]" /note="FMN-dependent NAD(P)H:quinone reductase; role in apoptosis-like cell death; may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions" /db_xref="GeneID:850698" /db_xref="SGD:S000004001" ORIGIN 1 mkvgiimgsv rakrvcpeia ayvkrtiens eelidqklki qvvdlqqial plyedddeli 61 paqiksvdey adsktrswsr ivnaldiivf vtpqynwgyp aalknaidrl yhewhgkpal 121 vvsygghggs kcndqlqevl hglkmnvigg vavkipvgti plpedivpql svhneeilql 181 lasciettrn k // LOCUS NP_013112 99 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR012C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013112 VERSION NP_013112.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181899.1 REFERENCE 1 (residues 1 to 99) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 99) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 99) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 99) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09330. On Oct 2, 2003 this sequence version replaced NP_013112.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..99 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..99 /product="uncharacterized protein" /calculated_mol_wt="11948" CDS 1..99 /locus_tag="YLR012C" /coded_by="NM_001181899.1:1..300" /note="hypothetical protein; YLR012C is not an essential gene" /db_xref="GeneID:850699" /db_xref="SGD:S000004002" ORIGIN 1 mktvyykeit yqqylqlqpe qqekylalcq kdfeqeteri afdrqggvpg iarkfaqeev 61 awfdrvttws ymnayipsyr rrrnllkidm lkmsnaeey // LOCUS NP_013113 141 aa linear PLN 30-JUN-2025 DEFINITION Gat3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013113 VERSION NP_013113.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181900.1 REFERENCE 1 (residues 1 to 141) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 141) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 141) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 141) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 141) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09331. Method: conceptual translation. FEATURES Location/Qualifiers source 1..141 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..141 /product="Gat3p" /calculated_mol_wt="15880" Region <1..>141 /region_name="GAT1" /note="GATA Zn-finger-containing transcription factor [Transcription]; COG5641" /db_xref="CDD:227928" CDS 1..141 /gene="GAT3" /locus_tag="YLR013W" /coded_by="NM_001181900.1:1..426" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]" /note="Protein containing GATA family zinc finger motifs; involved in spore wall assembly; sequence similarity to GAT4, and the double mutant gat3 gat4 exhibits reduced dityrosine fluorescence relative to the single mutants" /db_xref="GeneID:850700" /db_xref="SGD:S000004003" ORIGIN 1 mniktlchpe ykrisvesll npveetidce kphsqtkint akpisaslyv ttnntavvqh 61 nvqkrkgvtr rcpqcavikt spqwregpdg evtlcnacgl fyrkiflvfg kdlakryfne 121 ikgvsvkrkv pkslygvtrt r // LOCUS NP_013114 904 aa linear PLN 30-JUN-2025 DEFINITION Ppr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013114 VERSION NP_013114.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181901.1 REFERENCE 1 (residues 1 to 904) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 904) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 904) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 904) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09332. Method: conceptual translation. FEATURES Location/Qualifiers source 1..904 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..904 /product="Ppr1p" /calculated_mol_wt="102593" Region 28..70 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(29,33,38..41,43,46,56) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(34,37,44,51,54,61) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 72..96 /region_name="ZIP_Ppr1" /note="Leucine zipper Dimerization coil of Ppr1-like transcription factors; cd14723" /db_xref="CDD:271240" Site order(72,76..77,80..81,83..84,86..88,90..91,94,96) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:271240" Region 75..94 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:271240" Region 278..744 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..904 /gene="PPR1" /locus_tag="YLR014C" /coded_by="NM_001181901.1:1..2715" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9858611]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9858611]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:7843415]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:7958913]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2204810]" /experiment="EXISTENCE:mutant phenotype:GO:1900399 positive regulation of pyrimidine nucleotide biosynthetic process [PMID:24189721]" /note="Zinc finger transcription factor; contains a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p" /db_xref="GeneID:850701" /db_xref="SGD:S000004004" ORIGIN 1 mkqkkfnskk snrtdlskrg dspnigisks rtackrcrlk kikcdqefps ckrcaklevp 61 cvsldpatgk dvprsyvffl edrlavmmrv lkeygvdptk irgnipatsd depfdlkkys 121 svsslgeegi lphngllady lvqkgnsmas saitsksmas pqtinvqrke flvnskkqdg 181 sallpetgsp mtsdaraeel rrcnkeisal gtmressfns flgdssgisf aklvftatnf 241 rqdsgddvld edikqreqky ngyaeaennp hfdplelppr haaevmisrf fvdtnsqlpl 301 lhrelflkky fepiygpwnp nialasdqtg insafeipit safsahtepk renvtekidv 361 cssvdvpwyd twetsqkvnm rpivelptkf hipyfflnii faighatqvl ksdittvaty 421 krratkyias lfsssdrlea lagtllmviy simrpnvpgv wytmgsvlrl tvdlglhsek 481 inknydaftr eirrrlfwcv ysldrqicsy fgrpfgipee sittrypsll ddsfitltnr 541 eiddysdlps pnpsskvial amykirriqa sivrilyapg aelprrfmdl eswrietyne 601 lerwfqvdvp knfemmnckf nsiwfdlnyh ysksilygls pkfptlndta fkivldstkg 661 tidvfynlcv nkkigytwva vhnmfmtgmt ylyvnfyskn nindcqekvs eytekvlivl 721 knligfcesa ktcytsykil ssvviklkfm qindakgifs dsnpltsqan rmssydkktn 781 vlgfddgtfd nkvfnrtnfe ekapfdipld efftelekhs nvsqfntldv segnqvines 841 astntssaln cqsytnnqdi mdilfqvtsg svwdeffvrs gngnegessy diskgknses 901 ggif // LOCUS NP_013115 505 aa linear PLN 30-JUN-2025 DEFINITION Bre2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013115 VERSION NP_013115.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181902.1 REFERENCE 1 (residues 1 to 505) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 505) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 505) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 505) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09333. Method: conceptual translation. FEATURES Location/Qualifiers source 1..505 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..505 /product="Bre2p" /calculated_mol_wt="58217" Region 101..>244 /region_name="SPRY_Ash2" /note="SPRY domain in Ash2; cd12872" /db_xref="CDD:293932" CDS 1..505 /gene="BRE2" /locus_tag="YLR015W" /gene_synonym="CPS60" /coded_by="NM_001181902.1:1..1518" /experiment="EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11805083|PMID:11742990]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:11742990]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11805083|PMID:11687631]" /experiment="EXISTENCE:mutant phenotype:GO:0042800 histone H3K4 methyltransferase activity [PMID:11752412|PMID:11805083]" /experiment="EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11752412|PMID:11687631|PMID:11742990]" /note="Subunit of COMPASS (Set1C) complex; COMPASS methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L" /db_xref="GeneID:850702" /db_xref="SGD:S000004005" ORIGIN 1 mklgiipyqe gtdivyknal qgqqegkrpn lpqmeathqi kssvqgtsye fvrtedipln 61 rrhfvyrpcs anpfftilgy gcteypfdhs gmsvmdrseg lsisrdgndl vsvpdqygwr 121 tarsdvcike gmtywevevi rggnkkfadg vnnkenadds vdevqsgiye kmhkqvndtp 181 hlrfgvcrre asleapvgfd vygygirdis lesihegkln cvlengsplk egdkigflls 241 lpsihtqikq akeftkrrif alnshmdtmn epwredaeng psrkklkqet tnkefqrall 301 edieyndvvr dqiairyknq lffeatdyvk ttkpeyyssd krerqdyyql edsylaifqn 361 gkylgkafen lkpllppfse lqynekfylg ywqhgearde sndknttsak kkkqqqkkkk 421 glilrnkyvn nnklgyypti scfnggtari iseedkleyl dqirsaycvd gnskvntldt 481 lykeqiaedi vwdiideleq ialqq // LOCUS NP_013116 204 aa linear PLN 30-JUN-2025 DEFINITION Pml1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013116 VERSION NP_013116.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181903.1 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09334. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..204 /product="Pml1p" /calculated_mol_wt="23523" Region 60..202 /region_name="FHA_PML1-like" /note="forkhead associated (FHA) domain found in Saccharomyces cerevisiae pre-mRNA leakage protein 1 (PML1) and similar proteins; cd22681" /db_xref="CDD:438733" Site order(107..109,135..138,140,161,163..164) /site_type="other" /note="putative phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438733" CDS 1..204 /gene="PML1" /locus_tag="YLR016C" /coded_by="NM_001181903.1:1..615" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:15565172]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0070274 RES complex [PMID:15565172]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:15565172]" /experiment="EXISTENCE:mutant phenotype:GO:0051237 maintenance of RNA location [PMID:16162818]" /note="Subunit of the RES complex; RES complex is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p" /db_xref="GeneID:850703" /db_xref="SGD:S000004006" ORIGIN 1 mfhrrkrpyn trnyghddkk fksqyidimp dfspsgllel esnnkegial khvepqdais 61 pdnymdmlgl eardrtmyel viyrkndkdk gpwkrydlng rscylvgrel ghsldtdldd 121 rteivvadig ipeetsskqh cviqfrnvrg ilkcyvmdld ssngtclnnv vipgaryiel 181 rsgdvltlse feedndyeli fmnv // LOCUS NP_013117 337 aa linear PLN 30-JUN-2025 DEFINITION S-methyl-5-thioadenosine phosphorylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013117 VERSION NP_013117.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181904.1 REFERENCE 1 (residues 1 to 337) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 337) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 337) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 337) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09335. Method: conceptual translation. FEATURES Location/Qualifiers source 1..337 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..337 /product="S-methyl-5-thioadenosine phosphorylase" /EC_number="2.4.2.28" /calculated_mol_wt="37726" Region 35..289 /region_name="MTAP_SsMTAPII_like_MTIP" /note="5'-deoxy-5'-methylthioadenosine phosphorylases (MTAP) similar to Sulfolobus solfataricus MTAPII and Pseudomonas aeruginosa PAO1 5'-methylthioinosine phosphorylase (MTIP); cd09010" /db_xref="CDD:350161" Site order(40,88..89,97,121..124,162,206,211,228..231,253..254, 256,267,270) /site_type="active" /db_xref="CDD:350161" Site order(40,88..89,121..122,231) /site_type="other" /note="phosphate binding site [ion binding]" /db_xref="CDD:350161" Site order(95..99,140..144,151..152,154,156,162..166,209..216, 219,223..224,230,237,257,267) /site_type="other" /note="homohexamer interface [polypeptide binding]" /db_xref="CDD:350161" CDS 1..337 /gene="MEU1" /locus_tag="YLR017W" /coded_by="NM_001181904.1:1..1014" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8807288]" /experiment="EXISTENCE:direct assay:GO:0017061 S-methyl-5-thioadenosine phosphorylase activity [PMID:14506228]" /experiment="EXISTENCE:direct assay:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:14506228]" /experiment="EXISTENCE:mutant phenotype:GO:0006537 glutamate biosynthetic process [PMID:8807288]" /experiment="EXISTENCE:mutant phenotype:GO:0017061 S-methyl-5-thioadenosine phosphorylase activity [PMID:14506228]" /experiment="EXISTENCE:mutant phenotype:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:18625006|PMID:14506228]" /note="Methylthioadenosine phosphorylase (MTAP); catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression" /db_xref="GeneID:850704" /db_xref="SGD:S000004007" ORIGIN 1 mnrikntfsv akrlklskvm tnselpsife gtvdlgiigg tglynldcle piallppmvt 61 pwgttsspvt isqfvgtnsh fhvafiarhg inheypptkv pfranmaalk nlnckavlsf 121 savgslqphi kprdfvlpqq iidrtkgirh ssyfndeglv ghvgfgqpfs qkfaeyiyqf 181 kneitnpese epchlhydkd mtvvcmegpq fstraeskmy rmfgghvinm svipeaklar 241 ecelpyqmic mstdydawrd eaepvtvetv ignltnngrn anilaskiiv smakeipefm 301 htgdglrgsi kksistkpea msketlerlr ylfpnyw // LOCUS NP_013118 299 aa linear PLN 30-JUN-2025 DEFINITION Pom34p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013118 VERSION NP_013118.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181905.1 REFERENCE 1 (residues 1 to 299) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 299) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 299) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 299) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09336. Method: conceptual translation. FEATURES Location/Qualifiers source 1..299 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..299 /product="Pom34p" /calculated_mol_wt="34101" Region 40..188 /region_name="NPCC" /note="Nuclear pore complex component; pfam08058" /db_xref="CDD:400412" CDS 1..299 /gene="POM34" /locus_tag="YLR018C" /coded_by="NM_001181905.1:1..900" /experiment="EXISTENCE:curator inference:GO:0017056 structural constituent of nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005640 nuclear outer membrane [PMID:16361228]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0070762 nuclear pore transmembrane ring [PMID:10684247|PMID:19414609]" /experiment="EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:16361228]" /experiment="EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:19414609]" /experiment="EXISTENCE:genetic interaction:GO:0030474 spindle pole body duplication [PMID:19571182|PMID:20713690]" /experiment="EXISTENCE:mutant phenotype:GO:0006913 nucleocytoplasmic transport [PMID:16361228]" /experiment="EXISTENCE:physical interaction:GO:0070762 nuclear pore transmembrane ring [PMID:19414609]" /note="Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication" /db_xref="GeneID:850705" /db_xref="SGD:S000004008" ORIGIN 1 mkiqagqlgl ddndvpgplp dtdskpssqs qndtpmfklg nfespvlkel srrtvnkeme 61 tqrimtnvia fafwnllvkf ikffwnnthv grqfcnrlsr ihlymltfht lkkaniiyht 121 tfswlnaell dylfhllisl nilfslwkll stvkvsdlnl tdrqkkllgv dmqssvdtgl 181 qpqhphyvst skisqmaqnk thipqtnlkn hpaylfkgle tplkarqrem aeeqtklqsq 241 slhtknvfgt lqrhsgisst lvsanndnns phtpvtrkgy ipsskyaymm nsqsprgki // LOCUS NP_013119 397 aa linear PLN 30-JUN-2025 DEFINITION putative phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013119 VERSION NP_013119.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181906.1 REFERENCE 1 (residues 1 to 397) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 397) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 397) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 397) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09337. Method: conceptual translation. FEATURES Location/Qualifiers source 1..397 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..397 /product="putative phosphatase" /calculated_mol_wt="44641" Region 200..>239 /region_name="YqeG" /note="Predicted phosphohydrolase YqeG, HAD superfamily [General function prediction only]; COG2179" /db_xref="CDD:441782" Region 228..383 /region_name="NIF" /note="NLI interacting factor-like phosphatase; pfam03031" /db_xref="CDD:397254" Site order(233..237,241..242,288..291,295,327,343..344,346..348) /site_type="active" /db_xref="CDD:319823" CDS 1..397 /gene="PSR2" /locus_tag="YLR019W" /coded_by="NM_001181906.1:1..1194" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0034198 cellular response to amino acid starvation [PMID:30142151]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:12090248]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12090248]" /experiment="EXISTENCE:genetic interaction:GO:1904262 negative regulation of TORC1 signaling [PMID:30142151]" /note="Putative plasma membrane phosphatase; involved in the general stress response and inactivating dephosphorylation of Mep2p; required along with Psr1p and binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr1p; member of the HAD family of protein phosphatases" /db_xref="GeneID:850706" /db_xref="SGD:S000004009" ORIGIN 1 mgfianilcc ssdtskthrq rqppetnhnr nrnrkhssnk aqtqgrkqka tpngdkmqys 61 tpeillsssd sgsnagsktm qengnsgngk laplsrdhsn nsydeekeye dynegdvemt 121 evnnageeee eddeakekqd hvvheynvda drnssindea ppqqglyqvg qedmnpqyva 181 sspdndlnli ptteedfsdl thlqpdqyha pgydtllppk lqefqqkkcl ildldetlvh 241 ssfkymhsad fvlpveiddq vhnvyvikrp gvdeflnrvs qlyevvvfta svsryanpll 301 dtldpngtih hrlfreacyn yegnyiknls qigrplseti ildnspasyi fhpqhavpis 361 swfsdthdne lldiiplled lssgnvldvg svldvti // LOCUS NP_013120 538 aa linear PLN 30-JUN-2025 DEFINITION sterol esterase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013120 VERSION NP_013120.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181907.1 REFERENCE 1 (residues 1 to 538) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 538) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 538) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 538) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09338. Method: conceptual translation. FEATURES Location/Qualifiers source 1..538 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..538 /product="sterol esterase" /EC_number="3.1.1.13" /calculated_mol_wt="62316" Region 163..>298 /region_name="PLN02872" /note="triacylglycerol lipase" /db_xref="CDD:215470" Region 194..435 /region_name="alpha/beta hydrolases" /note="A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a...; cl21494" /db_xref="CDD:473884" CDS 1..538 /gene="YEH2" /locus_tag="YLR020C" /coded_by="NM_001181907.1:1..1617" /experiment="EXISTENCE:direct assay:GO:0004771 sterol ester esterase activity [PMID:15713625|PMID:15632184]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15632184]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15713625]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:14587103]" /experiment="EXISTENCE:mutant phenotype:GO:0004771 sterol ester esterase activity [PMID:15632184]" /experiment="EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:15713625|PMID:15632184]" /note="Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication" /db_xref="GeneID:850707" /db_xref="SGD:S000004010" ORIGIN 1 mvnkvvdevq rlvsaiilts fmtglfilsl wknyvtvhfq hkndprdtrs srtkiqpndk 61 kkkrparhsr plsissttpl dlqrdqenni eydrtvtskl smtsnaslse ngdgnanikm 121 etnvnqapya aenpfqnial aedtklvpdl kyyykeygid ieefevetdd gfiidlwhfk 181 srlndgveev krepilllhg llqscgafas sgrkslayfl yesgfdvwlg nnrcglnakw 241 nmkklgndhs kkwdwdmhqm vqydlkalin yvldstgyak lslvahsqgt tqgfmglvng 301 eklyasdfkl vdklenfval apavypgpll dekafvrlma kgidspwyfg rrsfiplmmt 361 mrklmvgtki fsflsyimfn ylfdwndvlw drvlrdrnfl fspvhisvkl mqwwlsplpn 421 klsfkkgaek ifpdkktwfp iakndddsgn nldnnklhln pkrqnseefp hiimfipkqd 481 rlvdgerlin hfinheanav ykiwyideys hldvlwahdv idrigkpmie nlrfpnar // LOCUS NP_013121 179 aa linear PLN 30-JUN-2025 DEFINITION Irc25p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013121 VERSION NP_013121.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181908.1 REFERENCE 1 (residues 1 to 179) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 179) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 179) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 179) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09339. Method: conceptual translation. FEATURES Location/Qualifiers source 1..179 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..179 /product="Irc25p" /calculated_mol_wt="19930" Region 1..174 /region_name="POC3_POC4" /note="20S proteasome chaperone assembly proteins 3 and 4; pfam10448" /db_xref="CDD:402192" CDS 1..179 /gene="IRC25" /locus_tag="YLR021W" /gene_synonym="DMP2; PBA3; POC3" /coded_by="NM_001181908.1:1..540" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17707236]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17707236]" /experiment="EXISTENCE:genetic interaction:GO:0051131 chaperone-mediated protein complex assembly [PMID:17707236]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:18278055|PMID:18260085]" /experiment="EXISTENCE:mutant phenotype:GO:0051131 chaperone-mediated protein complex assembly [PMID:17707236]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:17660569]" /experiment="EXISTENCE:physical interaction:GO:0051131 chaperone-mediated protein complex assembly [PMID:18278055]" /note="Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)" /db_xref="GeneID:850708" /db_xref="SGD:S000004011" ORIGIN 1 misyefqthl pkgkdsslna ssenkelyvq athfnntill qirlngemds tyevsskgln 61 pildinvpla gnlgntggdy ddeeeefvrd hlsdyqvvtk lgdsadpkvp vvcvqiaely 121 rrvilpevsg tmaqdnmqfs llismsskiw ratkeqsadd ndfgklvfvl kcikdmyak // LOCUS NP_013122 250 aa linear PLN 30-JUN-2025 DEFINITION guanine nucleotide exchange factor SDO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013122 VERSION NP_013122.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181909.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09340. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..250 /product="guanine nucleotide exchange factor SDO1" /calculated_mol_wt="28152" Region 9..244 /region_name="RNA_SBDS" /note="rRNA metabolism protein, SBDS family; TIGR00291" /db_xref="CDD:129392" CDS 1..250 /gene="SDO1" /locus_tag="YLR022C" /coded_by="NM_001181909.1:1..753" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:23831625]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:19350533]" /experiment="EXISTENCE:direct assay:GO:0070180 large ribosomal subunit rRNA binding [PMID:19350533]" /experiment="EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:19350533]" /experiment="EXISTENCE:direct assay:GO:1990932 5.8S rRNA binding [PMID:19350533]" /experiment="EXISTENCE:mutant phenotype:GO:0042256 cytosolic ribosome assembly [PMID:17353896]" /note="Guanine nucleotide exchange factor (GEF) for Ria1p; essential protein involved in ribosome maturation; with Ria1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archaea and eukaryotes" /db_xref="GeneID:850709" /db_xref="SGD:S000004012" ORIGIN 1 mpinqpsgqi kltnvslvrl kkarkrfeva cyqnkvqdyr kgiekdldev lqihqvfmnv 61 skglvanked lqkcfgttnv ddvieeimhk geiqlseker qlmlnkvnne mltivsakci 121 npvskkrypp tmihkalqel kfspvinkpa klqaleaikl lvskqiipiv rakmkvkvai 181 sepsrqpeli ekiskliass pgestkpeld pwtctglidp vnyrdlmtlc dkkgtvqvld 241 mavidntthn // LOCUS NP_013123 543 aa linear PLN 30-JUN-2025 DEFINITION Izh3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013123 VERSION NP_013123.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181910.1 REFERENCE 1 (residues 1 to 543) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 543) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 543) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 543) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09341. Method: conceptual translation. FEATURES Location/Qualifiers source 1..543 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..543 /product="Izh3p" /calculated_mol_wt="62440" Region 252..529 /region_name="HlyIII" /note="Haemolysin-III related; pfam03006" /db_xref="CDD:427098" CDS 1..543 /gene="IZH3" /locus_tag="YLR023C" /coded_by="NM_001181910.1:1..1632" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:15060275]" /note="Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity" /db_xref="GeneID:850710" /db_xref="SGD:S000004013" ORIGIN 1 mmdssskslt qyipspmgsl srlkqkgvdn fqkvkksgks iynynyskfv phpfstides 61 vkhsesgryd dleiirptke kevtssvykr nsgkslntes qfslgdsdaa tlvnsvatfk 121 lnnaststsl vsssstvcsq aksslrspts rlndtkikee nnyissvkdy cgpmrksmvk 181 teilieepln pttdiksfin synhgkaysl getqhlhyyq lpfpwrenry iihgyrfynt 241 hsksllsifn wygwhnetsn iwshllgaiy iiylaiydfp qsevwrnsqv ppqarwivfm 301 flaaalkcml ssvfwhtfng tsflklrskf acvdysgiti litasiltte fvtmyscywa 361 mytymsisla lgvfgvfmnw sprfdrpear plrirffill atmgvlsflh lifltdlhya 421 atlfspvtyk svvwylvgvv fygsfiperf rsdvqvdkti ptnyelstdl eiitkqreih 481 frevptahsk csscpshaks fkslwwvdyf gcshtfwhff vvlgvighyr aildmfakrw 541 ils // LOCUS NP_013124 1872 aa linear PLN 30-JUN-2025 DEFINITION putative ubiquitin-protein ligase UBR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013124 VERSION NP_013124.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181911.2 REFERENCE 1 (residues 1 to 1872) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1872) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1872) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1872) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1872) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1872) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1872) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1872) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1872) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09342. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1872 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1872 /product="putative ubiquitin-protein ligase UBR2" /EC_number="2.3.2.27" /calculated_mol_wt="216648" Region 96..171 /region_name="ZnF_UBR1" /note="Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway; smart00396" /db_xref="CDD:197698" Region <1319..1369 /region_name="RING_Ubox" /note="RING finger (Really Interesting New Gene) domain and U-box domain superfamily; cl17238" /db_xref="CDD:473075" Region 1434..1842 /region_name="PRT6_C" /note="Proteolysis_6 C-terminal; pfam18995" /db_xref="CDD:465944" CDS 1..1872 /gene="UBR2" /locus_tag="YLR024C" /coded_by="NM_001181911.2:1..5619" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:15504724]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:15504724]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15504724]" /experiment="EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15504724]" /experiment="EXISTENCE:genetic interaction:GO:0034620 cellular response to unfolded protein [PMID:20462952]" /experiment="EXISTENCE:genetic interaction:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:20462952]" /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:15504724]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:15504724]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:15504724|PMID:18070918]" /experiment="EXISTENCE:physical interaction:GO:1990304 MUB1-RAD6-UBR2 ubiquitin ligase complex [PMID:18070918]" /note="Cytoplasmic ubiquitin-protein ligase (E3); component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex required for the ubiquitination and degradation of Rpn4p; mediates formation of the ternary complex" /db_xref="GeneID:850711" /db_xref="SGD:S000004014" ORIGIN 1 medsdlsitn irdfltelpk lakceysett syllwktlnl rlkhsdndin wrslvsilns 61 eawenekyrd ilngrkwrtl efendhhsvg nmhigtactr lcfpsetiyy cftcstnply 121 eicelcfdke khvnhsyvak vvmrpegric hcgdpfafnd psdafkckne lnnipisndn 181 snvtddenvi sllnyvldfl idvtvsykee aeahsserka sslmhpnqns itddimekhe 241 ceplvndenf vffdnnwsnt rkeahmewai qieeeecnvh ymdlastitr ilntpveyai 301 sitkaledsh dvvtvlqsen ffeidqiake fqkenivvhv rkaddifkrk ltddltdwly 361 slcfkaatsl qnkyalrism ldvwyshfsk mrvsptntnp dfskinllgg flisnedsde 421 swfkpwslen iederiskil tnynerlira hspntvshfy nfygsrfqyi iinsinilsk 481 kskfkmlkim aslfslrdes rkflaaqyid vylsvlydav asdakecqvt lmsilgqytf 541 qdpsianmti ssgfiertir faftlmafnp edlmsylpis lyngfklpte tirnrrtiic 601 fkdlctimsa ntvpeellsn eaifnaiies fsefsnvlpl kretkehvev enfdfsafyf 661 ffssilimtd gytrsislvk daafrkqivl klldvaqtre fesltnsrka ispdnastne 721 ndsnkatlst vreticnyva etinfqvgvn tqyffnpmsy lfkfviqwsq cgryepipas 781 ltnyinlfev fqdkqkalyi sesalstlvl igqinvgfwv rngtpithqa rmytkysmre 841 ftyisdifnv qfsmamcnpd elmvtylsrw glkhwangvp mydypdtett vavvnecill 901 liqlltevrs lvmksskegf ertfkseiih alcfdtcsya qivncipehi tkhpsfdiyl 961 ekyanytspv sltdngifvl kekykdeidp yyiglsssrr ydveknirln manlkkmkye 1021 dtfvpakkvk dllkntlfsg lysissvntf glflkntldh iikydydnll prvvhlihlc 1081 vvnnlnefmg ilwheyaivd tefchyhsig silyycllkd nfseshgkir eifrylmeta 1141 phvnvnsylr eqttsytpgi lwptkedksh kdkeferkkh larlrkkklm kklaqqqmkf 1201 mennsvdtsd istprttsps lsptrinaen ssntinsccd ddcvfckmpk dddvfvyfsy 1261 qernicdhgi dftnptdvnr inslfsgkqt kdsaiqenpq dddgtrlkft scepvlracg 1321 hgshtkclsg hmksirgiqn qttkniplsy gsgliycpvc nslsnsflpk tndidkrtss 1381 qffmciekrs eaeenldpms sicikaamil gdlqgkkvtt iedaykvvns vfintisnte 1441 lrlrshkkeg kivnmeriss qciltlhlvc elksfiykkf vnsktfssei srkiwnwnef 1501 likgnnvnll lymsqnfdni dggktpqppn lciyemfkrr fhqlllllar dmmrvnfykd 1561 crnkikissn gseepstsfs ylfntfkkyv dlfkpddvrf dftslekikd ficslllesl 1621 sifcrrtfll fniqydddgd gdnnnnrsnn fmdvkqreie lifryfklpn lthflkdffy 1681 neltqniery ndgndnlriq qviydmvqni ntraypspeh iqlielplnl skfsldndei 1741 snkcdkyeia vcllcgqkch iqksialqgy lqgectdhmr ngceitsayg vflmtgtnai 1801 ylsygkrgtf yaapylskyg etnedykfgt pvylnrarya nlaneivfgn miphivfrlt 1861 dgsadlggwe tm // LOCUS NP_013125 240 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-III subunit protein SNF7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013125 VERSION NP_013125.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181912.1 REFERENCE 1 (residues 1 to 240) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 240) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 240) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 240) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09343. Method: conceptual translation. FEATURES Location/Qualifiers source 1..240 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..240 /product="ESCRT-III subunit protein SNF7" /calculated_mol_wt="26856" Region 21..181 /region_name="Snf7" /note="pfam03357" /db_xref="CDD:460896" CDS 1..240 /gene="SNF7" /locus_tag="YLR025W" /gene_synonym="DID1; RNS4; VPL5; VPS32" /coded_by="NM_001181912.1:1..723" /experiment="EXISTENCE:direct assay:GO:0000815 ESCRT III complex [PMID:12194857]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9606181]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:29588378]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27803246]" /experiment="EXISTENCE:direct assay:GO:0061709 reticulophagy [PMID:31802527]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:29588378]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:9606181]" /experiment="EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:19234443]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15086794]" /note="One of four core subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; subunit of the endosomal sorting complex required for transport III (ESCRT-III) that forms flat spirals on lipid monolayers as part of the complexes role in driving membrane abscission" /db_xref="GeneID:850712" /db_xref="SGD:S000004015" ORIGIN 1 mwsslfgwts snaknkespt kaivrlrehi nllskkqshl rtqitnqene arifltkgnk 61 vmaknalkkk ktieqllskv egtmesmeqq lfsiesanln letmramqeg akamktihsg 121 ldidkvdetm deireqvelg deisdaisrp litganevde deldeeldml aqenanqets 181 kivnnnvnaa pisenkvslp svpsnkikqs ensvkdgeee edeededeka lrelqaemgl // LOCUS NP_013126 340 aa linear PLN 30-JUN-2025 DEFINITION t-SNARE syntaxin [Saccharomyces cerevisiae S288C]. ACCESSION NP_013126 VERSION NP_013126.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181913.1 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09344. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..340 /product="t-SNARE syntaxin" /calculated_mol_wt="38676" Region 1..20 /region_name="Syntaxin-5_N" /note="Syntaxin-5 N-terminal, Sly1p-binding domain; pfam11416" /db_xref="CDD:463276" Region 252..324 /region_name="SNARE_syntaxin5" /note="SNARE motif of syntaxin 5; cd15844" /db_xref="CDD:277197" Site order(253,255..256,258..263,265..267,269..270,272..274, 276..277,279..281,283..284,286..291,293..298,300..305, 307..309) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277197" Site 283 /site_type="other" /note="zero layer" /db_xref="CDD:277197" CDS 1..340 /gene="SED5" /locus_tag="YLR026C" /coded_by="NM_001181913.1:1..1023" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11959998|PMID:11001058]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:9725919]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:1400588]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11001058|PMID:11959998]" /experiment="EXISTENCE:direct assay:GO:0090083 regulation of inclusion body assembly [PMID:31433985]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9545229]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:7596416]" /experiment="EXISTENCE:mutant phenotype:GO:0048280 vesicle fusion with Golgi apparatus [PMID:9545229]" /note="cis-Golgi t-SNARE syntaxin; required for vesicular transport between the ER and the Golgi complex; binds at least 9 SNARE proteins; plays a role in autophagy by regulating formation of autophagic vesicles in Golgi" /db_xref="GeneID:850713" /db_xref="SGD:S000004016" ORIGIN 1 mnikdrtsef qqsvlsykkr nknfreqqre rlqekesenf annttgngks vsefqkkasg 61 iaheisstaq llsklavlak rkpmfndnpv eiaelsflik rkiyaieqsl vqlsqlkktd 121 vngntsnqss kqpsavqhsk nvvnllntqm knisgsfkdv leerqrlema nkdrwqkltt 181 dtghapaddq tqsnhaadlt tynnsnpfmt slldessekn nnssnqgels fpqndsqlml 241 meegqlsnnv ylqernrave tiestiqevg nlfqqlasmv qeqgeviqri danvddidln 301 isgaqrellk yfdriksnrw laakvffiif vffviwvlvn // LOCUS NP_013127 418 aa linear PLN 30-JUN-2025 DEFINITION aspartate transaminase AAT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013127 VERSION NP_013127.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181914.1 REFERENCE 1 (residues 1 to 418) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 418) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 418) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 418) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09345. On Oct 2, 2003 this sequence version replaced NP_013127.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..418 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..418 /product="aspartate transaminase AAT2" /EC_number="2.6.1.1" /calculated_mol_wt="45927" Region 2..410 /region_name="AAT_I" /note="Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl18945" /db_xref="CDD:450240" Site order(107..109,135,188,219,252,254..255,263) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99734" Site order(110,145,212,261..263,303,306) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:99734" Site 255 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99734" CDS 1..418 /gene="AAT2" /locus_tag="YLR027C" /gene_synonym="ASP5; THR5" /coded_by="NM_001181914.1:1..1257" /experiment="EXISTENCE:direct assay:GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity [PMID:1859361]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:9288922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9288922]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:35621265]" /experiment="EXISTENCE:mutant phenotype:GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity [PMID:9288922]" /experiment="EXISTENCE:mutant phenotype:GO:0005777 peroxisome [PMID:9288922]" /experiment="EXISTENCE:mutant phenotype:GO:0006532 aspartate biosynthetic process [PMID:15780654|PMID:9288922]" /experiment="EXISTENCE:mutant phenotype:GO:0032938 negative regulation of translation in response to oxidative stress [PMID:35621265]" /note="Cytosolic aspartate aminotransferase involved in the metabolism of nitrogen and amino acids such as aspartate; localizes to and functions in peroxisomes in oleate-grown cells; moonlighting role as a ribosome-associated protein that modulates translation in response to stress" /db_xref="GeneID:850714" /db_xref="SGD:S000004017" ORIGIN 1 msatlfnnie llppdalfgi kqrygqdqra tkvdlgigay rddngkpwvl psvkaaekli 61 hndssynhey lgitglpslt snaakiifgt qsdafqedrv isvqslsgtg alhisakffs 121 kffpdklvyl skptwanhma ifenqglkta typywanetk sldlngflna iqkapegsif 181 vlhscahnpt gldptseqwv qivdaiaskn hialfdtayq gfatgdldkd ayavrlgvek 241 lstvspvfvc qsfaknagmy gervgcfhla ltkqaqnkti kpavtsqlak iirsevsnpp 301 aygakivakl letpelteqw hkdmvtmssr itkmrhalrd hlvklgtpgn wdhivnqcgm 361 fsftgltpqm vkrleethav ylvasgrasi aglnqgnvey vakaidevvr fytieakl // LOCUS NP_013128 591 aa linear PLN 30-JUN-2025 DEFINITION bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013128 VERSION NP_013128.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181915.1 REFERENCE 1 (residues 1 to 591) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 591) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 591) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 591) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09346. Method: conceptual translation. FEATURES Location/Qualifiers source 1..591 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..591 /product="bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE16" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /calculated_mol_wt="65152" Region 6..545 /region_name="purH" /note="phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGR00355" /db_xref="CDD:273032" CDS 1..591 /gene="ADE16" /locus_tag="YLR028C" /coded_by="NM_001181915.1:1..1776" /experiment="EXISTENCE:direct assay:GO:0003937 IMP cyclohydrolase activity [PMID:10877846]" /experiment="EXISTENCE:direct assay:GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity [PMID:10877846]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10877846]" /experiment="EXISTENCE:direct assay:GO:0006164 purine nucleotide biosynthetic process [PMID:10877846]" /experiment="EXISTENCE:direct assay:GO:0006189 'de novo' IMP biosynthetic process [PMID:10877846]" /experiment="EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:10877846]" /experiment="EXISTENCE:mutant phenotype:GO:0006189 'de novo' IMP biosynthetic process [PMID:10877846]" /note="Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine" /db_xref="GeneID:850715" /db_xref="SGD:S000004018" ORIGIN 1 mgkytktail svydktglld lakglvennv rilasggtan mvreagfpvd dvssithape 61 mlggrvktlh pavhagilar nlegdekdlk eqhidkvdfv vcnlypfket vakigvtvqe 121 aveeidiggv tllraaaknh srvtilsdpn dysiflqdls kdgeisqdlr nrfalkafeh 181 tadydaaisd ffrkqysegk aqlplrygcn phqrpaqayi tqqeelpfkv lcgtpgyinl 241 ldalnswplv kelsaslnlp aaasfkhvsp agaavglpls dverqvyfvn dmedlsplac 301 ayarargadr mssfgdfial snivdvatak iiskevsdgv iapgyepeal nilskkkngk 361 ycilqidpny vpgqmesrev fgvtlqqkrn daiinqstfk eivsknkalt eqavidltva 421 tlvlkytqsn svcyakngmv vglgagqqsr ihctrlagdk tdnwwlrqhp kvlnmkwakg 481 ikradksnai dlfvtgqrie gpekvdyesk feevpepftk eerlewlskl nnvslssdaf 541 fpfpdnvyra vqsgvkfita psgsvmdkvv fqaadsfdiv yvenpirlfh h // LOCUS NP_013129 204 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL15 RPL15A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013129 VERSION NP_013129.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181916.1 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09347. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..204 /product="60S ribosomal protein eL15 RPL15A" /calculated_mol_wt="24291" Region 2..189 /region_name="Ribosomal_L15e" /note="Ribosomal L15; pfam00827" /db_xref="CDD:459950" CDS 1..204 /gene="RPL15A" /locus_tag="YLR029C" /gene_synonym="RPL10A" /coded_by="NM_001181916.1:1..615" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:6814480]" /note="Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication" /db_xref="GeneID:850716" /db_xref="SGD:S000004019" ORIGIN 1 mgaykyleel qrkkqsdvlr flqrvrvwey rqknvihraa rptrpdkarr lgykakqgfv 61 iyrvrvrrgn rkrpvpkgat ygkptnqgvn elkyqrslra taeervgrra anlrvlnsyw 121 vnqdstykyf evilvdpqhk airrdarynw icdpvhkhre argltatgkk srginkghkf 181 nntkagrrkt wkrqntlslw ryrk // LOCUS NP_013130 263 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR030W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013130 VERSION NP_013130.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181917.1 REFERENCE 1 (residues 1 to 263) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 263) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 263) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 263) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09348. Method: conceptual translation. FEATURES Location/Qualifiers source 1..263 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..263 /product="uncharacterized protein" /calculated_mol_wt="29854" CDS 1..263 /locus_tag="YLR030W" /coded_by="NM_001181917.1:1..792" /note="hypothetical protein; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W" /db_xref="GeneID:850717" /db_xref="SGD:S000004020" ORIGIN 1 megeqimeyv qetpiipkri ihysipkqmi tkpaphvemt lvantfrdmd lpqhpvihdc 61 wqnkeystqr ysgnvaqqrl sfeehpneec qnsvglikrv stffkkrpls rknsiksigd 121 vksearnrge gllgevdnln eqnvrenlts ehekspegds kryglfsfee tppiqvleqg 181 ninselssfk ntslaenkrs sdsfvslkpg edehspleis tcgnltered lqsgeerfds 241 aaqnikvasm kekkkifkgn ktd // LOCUS NP_013131 186 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR031W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013131 VERSION NP_013131.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181918.1 REFERENCE 1 (residues 1 to 186) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 186) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 186) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 186) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09349. Method: conceptual translation. FEATURES Location/Qualifiers source 1..186 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..186 /product="uncharacterized protein" /calculated_mol_wt="21715" CDS 1..186 /locus_tag="YLR031W" /coded_by="NM_001181918.1:1..561" /note="hypothetical protein; S288C contains an in-frame stop codon between ORFs YLR030W and YLR031W; YLR031W has a paralog, YMR124W, that arose from the whole genome duplication" /db_xref="GeneID:850718" /db_xref="SGD:S000004021" ORIGIN 1 mpvlntrtsy pnidfhgtkv sdvldafefe khddplrdkw ntlqfleksf eskfesasel 61 iqggelaaik ernfqlakln nlcfrvresi krrqdlekkl rtlsqdtdne llflmlener 121 rkkssviief lseiireksk rltaeeqgfv nqnevkplil dlsarinrln siletkntci 181 rrlsnq // LOCUS NP_013132 1169 aa linear PLN 30-JUN-2025 DEFINITION DNA helicase RAD5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013132 VERSION NP_013132.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181919.1 REFERENCE 1 (residues 1 to 1169) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1169) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1169) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1169) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09350. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1169 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1169 /product="DNA helicase RAD5" /calculated_mol_wt="133872" Region 176..284 /region_name="HIRAN" /note="HIRAN domain; pfam08797" /db_xref="CDD:400928" Region <527..1143 /region_name="HepA" /note="Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair]; COG0553" /db_xref="CDD:440319" Region 909..973 /region_name="RING-HC_RAD5" /note="RING finger, HC subclass, found in radiation sensitivity protein 5 (RAD5) and similar proteins; cd23131" /db_xref="CDD:438493" CDS 1..1169 /gene="RAD5" /locus_tag="YLR032W" /gene_synonym="REV2; SNM2" /coded_by="NM_001181919.1:1..3510" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:19706603]" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:17936713]" /experiment="EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:17936713]" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:24393774]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10880451]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006301 postreplication repair [PMID:17936713]" /experiment="EXISTENCE:direct assay:GO:0008094 ATP-dependent activity, acting on DNA [PMID:17936713]" /experiment="EXISTENCE:direct assay:GO:0009378 four-way junction helicase activity [PMID:17936713]" /experiment="EXISTENCE:direct assay:GO:0010994 free ubiquitin chain polymerization [PMID:19706603]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:18757916]" /experiment="EXISTENCE:direct assay:GO:0070987 error-free translesion synthesis [PMID:18757916]" /experiment="EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:16224103]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16224103]" /experiment="EXISTENCE:mutant phenotype:GO:0042275 error-free postreplication DNA repair [PMID:19079240]" /experiment="EXISTENCE:mutant phenotype:GO:0042276 error-prone translesion synthesis [PMID:18757916|PMID:23142547]" /experiment="EXISTENCE:mutant phenotype:GO:0070987 error-free translesion synthesis [PMID:18757916]" /note="DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, and error-prone translesion synthesis; required for UV and MMS-associated unequal sister chromatid exchange (SCE) but not for double-strand break associated unequal SCE; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; human homolog HLTF can complement yeast null mutant" /db_xref="GeneID:850719" /db_xref="SGD:S000004022" ORIGIN 1 mshieqeerk rffnddldts etslnfksen kesflfansh ndddddvvvs vsdttegegd 61 rsivpvrrei eeegqnqfit ellriipemp kdlvmelnek fgsqeeglsl alshyfdhns 121 gtsiskipss pnqlntlsdt snstlspssf hpkrrriygf rnqtrledkv twkrfigalq 181 vtgmatrptv rplkygsqmk lkrsseeisa tkvydsrgrk kasmaslvri fdiqydreig 241 rvsediaqil ypllssheis fevtlifcdn krlsigdsfi lqldcfltsl ifeerndges 301 lmkrrrtegg nkrekdngnf grtltetdee lesrskrlal lklfdklrlk pildeqkale 361 khkielnsdp eiidldndei csnqvtevhn nlrdtqheee tmnlnqlktf ykaaqssesl 421 kslpetepsr dvfklelrny qkqgltwmlr reqefakaas dgeasetgan minplwkqfk 481 wpndmswaaq nlqqdhvnve dgiffyanlh sgefslakpi lktmikggil sdemglgktv 541 aayslvlscp hdsdvvdkkl fdientavsd nlpstwqdnk kpyaskttli vvpmslltqw 601 sneftkanns pdmyhevyyg gnvsslktll tktktpptvv lttygivqne wtkhskgrmt 661 dedvnissgl fsvnfyriii deghnirnrt tvtskavmal qgkckwvltg tpiinrlddl 721 yslvkfleld pwrqinywkt fvstpfeskn ykqafdvvna ilepvllrrt kqmkdkdgkp 781 lvelppkevv ikrlpfsksq dllykflldk aevsvksgia rgdllkkyst ilvhilrlrq 841 vcchpgligs qdendedlsk nnklvteqtv eldslmrvvs erfdnsfske eldamiqrlk 901 vkypdnksfq slecsictte pmdldkalft ecghsfcekc lfeyiefqns knlglkcpnc 961 rnqidacrll alvqtnsnsk nlefkpyspa sksskitall kelqllqdss ageqvvifsq 1021 fstyldilek elthtfskdv akiykfdgrl slkertsvla dfavkdysrq killlslkag 1081 gvglnltcas haymmdpwws psmedqaidr lhrigqtnsv kvmrfiiqds ieekmlriqe 1141 kkrtigeamd tdederrkrr ieeiqmlfe // LOCUS NP_013133 502 aa linear PLN 30-JUN-2025 DEFINITION Rsc58p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013133 VERSION NP_013133.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181920.1 REFERENCE 1 (residues 1 to 502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 502) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09351. Method: conceptual translation. FEATURES Location/Qualifiers source 1..502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..502 /product="Rsc58p" /calculated_mol_wt="57664" Region 39..122 /region_name="Bromodomain" /note="Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; cl02556" /db_xref="CDD:445827" CDS 1..502 /gene="RSC58" /locus_tag="YLR033W" /coded_by="NM_001181920.1:1..1509" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12052880]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:12052880]" /note="Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance" /db_xref="GeneID:850720" /db_xref="SGD:S000004023" ORIGIN 1 mtesvggnkl vdflvnvqsi lnaasvkchv vdesfpakff eknpdkiyes yckfiknrsn 61 seglirnedk lvlttinkrf engeyepiqg gfyklyhdik lvctilihfy pqgtrnyqlv 121 dkfykfssel llreccrigi altqtnniks rsgkllsgne mdeyddddat eldkiisydf 181 ikismnytvp isqtyqirtk dmdlfssiis ksnldkrphe lpntnfkinn vlpqtdiene 241 aprlgfvgan tsnipdptlp ptemmtrflh pnwyalpttv wlkygnynsw apsfnengtv 301 vdsttrgliw lerigymdly eknekkvkqe ellntneegi nrkqndennk nvdgksngvq 361 ddggdndnda tiasansest enkeqfiikl qnlynwtpsn yigddeienf rngtpdklvs 421 dsllklkrlr kerilnkvlk ptteerelyf kvkrilkevi lakkvskvpi nnvrafpvlq 481 tnyngsipvv raqpgrkrkh kk // LOCUS NP_013134 473 aa linear PLN 30-JUN-2025 DEFINITION putative divalent metal ion transporter SMF3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013134 VERSION NP_013134.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181921.2 REFERENCE 1 (residues 1 to 473) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 473) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 473) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 473) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09352. Method: conceptual translation. FEATURES Location/Qualifiers source 1..473 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..473 /product="putative divalent metal ion transporter SMF3" /calculated_mol_wt="51645" Region 10..402 /region_name="SLC5-6-like_sbd" /note="Solute carrier families 5 and 6-like; solute binding domain; cl00456" /db_xref="CDD:444915" CDS 1..473 /gene="SMF3" /locus_tag="YLR034C" /coded_by="NM_001181921.2:1..1422" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:11027260]" /experiment="EXISTENCE:mutant phenotype:GO:0006826 iron ion transport [PMID:17681937]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:11027260]" /note="Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of Nramp family of metal transport proteins; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850721" /db_xref="SGD:S000004024" ORIGIN 1 mrsymqilqk fakfigpgil vsvaymdpgn yatsvsggaq ykytllfsif isnifavllq 61 clcvklgtit gydlaencrh nlpkklnytl ylfaevaiia tdlaevvgta ialqilfkip 121 ltwgvlltvl dvlvilmfyt pngqslkkvr vfefgvgilv igtcicfvle lfkvsipdka 181 elfkgflpsn iifkeqqaly islgilgatv mphslylgss ivkprlhdyd lkkygkvnar 241 pslsaikytl nyayaeliis lfliatfvns ailivagatl sgqpeaedad llsiykllvh 301 yispaaglif alamlcsgqs agiictlagq ivsegflqws lppwatrlct rliaivpclf 361 vtltmgekgi sdilnfsqvv lslilpivsa pliyftanrk lmvvhdengv vrapadvnai 421 adettplnsk hskivdftns rlltytsvfv waligslncy lvisyllgad ihf // LOCUS NP_013135 695 aa linear PLN 30-JUN-2025 DEFINITION mismatch repair protein MLH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013135 VERSION NP_013135.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181922.1 REFERENCE 1 (residues 1 to 695) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 695) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 695) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 695) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09353. Method: conceptual translation. FEATURES Location/Qualifiers source 1..695 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..695 /product="mismatch repair protein MLH2" /calculated_mol_wt="78118" Region 1..338 /region_name="mutl" /note="DNA mismatch repair protein MutL; TIGR00585" /db_xref="CDD:273155" CDS 1..695 /gene="MLH2" /locus_tag="YLR035C" /coded_by="NM_001181922.1:1..2088" /experiment="EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:28051769]" /experiment="EXISTENCE:direct assay:GO:0000405 bubble DNA binding [PMID:28051769]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:10679328]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15467363]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:10570173]" /experiment="EXISTENCE:physical interaction:GO:0032390 MutLbeta complex [PMID:10570173]" /note="Protein involved in mismatch repair and meiotic recombination; only certain frameshift intermediates are mismatch repair substrates; forms a complex with Mlh1p, plays accessory role in stimulating activity of MLH1/PMS1 complex" /db_xref="GeneID:850722" /db_xref="SGD:S000004025" ORIGIN 1 mtihqlspes qwkivsssfi ygpvaavrel ldnsidsgak kvfidvdstt ggceyisvkd 61 dgsgvdiidr psmcleytts kmsslgdisi lttlgfrgea lfllsnlcnq kgsmqvetkt 121 addvigekwl vdskggitng krykvscpvg ttvilrkllg glraryleis srprktfdel 181 iylinhysli hrnirfyfsl vslqkngaie rkqmqetldp kisrarslsl larlkkpvpl 241 nfiveenfvi dekinldlil prmvpesdvi nikrrfkfls vneralslnl etgktiskll 301 ssiyrdfsll dpmvwfinln cdtklldvni epekndvmik sfevifkkie nklkllleer 361 igietnmlgd khvqpsinek tspalviptp daeneiskgc gavsgkdktd ipqknsdliv 421 ptfydeanle nttivaatps ptkfsedkal deqtqltiss yrssssgsma sedstnwrhn 481 fqqelsense vagagsstlp ssltynyiet ipenedlels kdasisnpfm itkirnvnkk 541 lsenlleakr tscgdankrg mpnerqlsnt ekkeliklqq tygkrnntvd mtiprnskkk 601 vtdnyikkas cmhktrpklm hfseytnnyv ytlknekivk hdsdnfaket lwlrsrddat 661 spsssllqal rahvkkpghi eattnewclf tpdsp // LOCUS NP_013136 1155 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013136 VERSION NP_013136.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184318.1 REFERENCE 1 (residues 1 to 1155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1155) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09354. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1155 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="131486" Region 64..165 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region <307..563 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" Region 665..898 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1006..1142 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1010..1013,1047..1049,1052,1085,1112,1139) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1155 /locus_tag="YLR035C-A" /coded_by="NM_001184318.1:1..3468" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /note="Retrotransposon TYA Gag and TYB Pol genes; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); YLR035C-A is part of a mutant retrotransposon" /db_xref="GeneID:850724" /db_xref="SGD:S000007225" ORIGIN 1 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 61 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 121 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 181 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 241 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 301 ydaltfdedl nrltasyqsf iasneiqqsd dlniesdhdf qsdielhpeq prnvlskavs 361 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis diestgsggm 421 hrldvpllap msqsnthess haskskdfrh sdsysdnetn htnvpisstg gtnnktvpqt 481 seqetekrii hrspsidtss sesnslhhvv piktsdtcpk enteesiiad lplpdlppep 541 ptelsdsfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 601 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky iqayhkevnq 661 llkmktwdtd ryydrkeidp krvinsmfif nrkrggthka rfvargdiqh pdtydpgmqs 721 ntvhhyalmt slslasdnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 781 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 841 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 901 npkgrklsap gqpglyidqq eleleeddyk mkvhemqkli glasyvgykf rfdllyyint 961 laqhilfpsk qvldmtyeli qfiwntrdkq liwhkskpvk ptnklvvisd asygnqpyyk 1021 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlshlv qelnkkpitk 1081 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1141 lpiktfkllt nkwih // LOCUS NP_013137 203 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR036C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013137 VERSION NP_013137.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181923.1 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09355. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..203 /product="uncharacterized protein" /calculated_mol_wt="23247" Region 25..185 /region_name="DUF4668" /note="Domain of unknown function (DUF4668); pfam15701" /db_xref="CDD:406192" CDS 1..203 /locus_tag="YLR036C" /coded_by="NM_001181923.1:1..612" /note="Putative protein predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein" /db_xref="GeneID:850725" /db_xref="SGD:S000004026" ORIGIN 1 mkeaelsate sqdeipksns lliiekltka vcslyfincf mvpsvdnlie kypkaiiiki 61 idmilgavti slviivffly rknghfknen ktkpkrcskv vcpscaarkk ypkwfqlkyl 121 llvsmtafsf yfctkirfff ktdqtinlhr lsqlfrlqlg wicttallfy fydalilhsg 181 fiegyrcvng kgamsegktg qln // LOCUS NP_013138 124 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU23 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013138 VERSION NP_013138.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181924.1 REFERENCE 1 (residues 1 to 124) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 124) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 124) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 124) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09356. Method: conceptual translation. FEATURES Location/Qualifiers source 1..124 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..124 /product="seripauperin PAU23" /calculated_mol_wt="13047" Region 26..118 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..124 /gene="PAU23" /locus_tag="YLR037C" /gene_synonym="DAN2" /coded_by="NM_001181924.1:1..375" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Cell wall mannoprotein; has similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth" /db_xref="GeneID:850726" /db_xref="SGD:S000004027" ORIGIN 1 mvkltsivag vaaiaagvaa apatttlsps dervnlvelg vyvsdirahl aeyymfqaah 61 ptetypveia eavfnygdft tmltgipadq vtrvitgvpw ystrlrpais salskdgiyt 121 avpn // LOCUS NP_013139 83 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c oxidase subunit VIb [Saccharomyces cerevisiae S288C]. ACCESSION NP_013139 VERSION NP_013139.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181925.1 REFERENCE 1 (residues 1 to 83) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 83) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 83) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 83) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 83) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 83) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 83) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 83) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 83) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09357. Method: conceptual translation. FEATURES Location/Qualifiers source 1..83 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..83 /product="cytochrome c oxidase subunit VIb" /calculated_mol_wt="9657" Region 5..79 /region_name="Cyt_c_Oxidase_VIb" /note="Cytochrome c oxidase subunit VIb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cd00926" /db_xref="CDD:238466" Site order(9..12,21..24,53,56..62) /site_type="other" /note="Subunit VIb/II interface [polypeptide binding]" /db_xref="CDD:238466" Site 21 /site_type="other" /note="Subunit VIb/I interface [polypeptide binding]" /db_xref="CDD:238466" Site order(25,28,77) /site_type="other" /note="Subunit VIb/III interface [polypeptide binding]" /db_xref="CDD:238466" Site order(41,43..48) /site_type="other" /note="Subunit VIb/VIb interface [polypeptide binding]" /db_xref="CDD:238466" Site order(70,73..75) /site_type="other" /note="Subunit VIb/VIa interface [polypeptide binding]" /db_xref="CDD:238466" CDS 1..83 /gene="COX12" /locus_tag="YLR038C" /coded_by="NM_001181925.1:1..252" /experiment="EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0045277 respiratory chain complex IV [PMID:1331058]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:1331058]" /note="Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly and activity of cytochrome c oxidase; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV" /db_xref="GeneID:850727" /db_xref="SGD:S000004028" ORIGIN 1 madqensplh tvgfdarfpq qnqtkhcwqs yvdyhkcvnm kgedfapckv fwktynalcp 61 ldwiekwddq rekgifagdi nsd // LOCUS NP_013140 1056 aa linear PLN 30-JUN-2025 DEFINITION Ric1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013140 VERSION NP_013140.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181926.1 REFERENCE 1 (residues 1 to 1056) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1056) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1056) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1056) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1056) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1056) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1056) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1056) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1056) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09358. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1056 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1056 /product="Ric1p" /calculated_mol_wt="121519" Region <820..1043 /region_name="RIC1" /note="pfam07064" /db_xref="CDD:462078" CDS 1..1056 /gene="RIC1" /locus_tag="YLR039C" /coded_by="NM_001181926.1:1..3171" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:10990452]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10990452]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:24924636]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:10990452]" /experiment="EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10990452]" /experiment="EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:10990452]" /experiment="EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:11160819]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:10990452]" /experiment="EXISTENCE:physical interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10990452]" /experiment="EXISTENCE:physical interaction:GO:0034066 Ric1-Rgp1 guanyl-nucleotide exchange factor complex [PMID:10990452]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:10990452]" /note="Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes" /db_xref="GeneID:850728" /db_xref="SGD:S000004029" ORIGIN 1 mfikqseknt pkclykkkgk vrvlltgsck klntwkmhlw pvsppqllri pprnaelgeg 61 tkiddcnilq smtlpqanvl imltptrvli ynfkpmalva shertmaslk efgdnrsmkr 121 sapyndiieg liskkdsqyl lwhqgklify vmtdknfllt yqilknctne iifkeygipv 181 iepllmseee ansaeydynn dddtltvfdk nsssriiqng fgitkekgfl hflsnqenid 241 elpvkklelr lkvvlkfdye iidmigiktf skvgdgryee vlivlfphgl qiltisdfkv 301 sksslvevkk gsktivcnkq lmvlshdsve kqtivsiidi ekqaveaipl tdtpdelltc 361 levngylvvv ykekiicfdt rikkvshswk ppfviklcdk indkilllvs edsvnihfyt 421 efgnllfaty fdeddyngdn nndnskdkne kkaaeykisd fvcldkslit vshsgkyqvw 481 klweeikqtq fdfrnpkcyv ltntnndvii yspvtsssin ndnlqviklp tktfnnhiaf 541 vkinsslrlf atyvsnknil lihnletnmw ssfadqnvld lhwlgdnylv chmknddgst 601 nlkclqiplq eanpdvelsd yvmweynvpe ntivfslhvn tlsrykllkm ksknhnasek 661 qpdallktae iilvtdtqti vfdvistvhp cglniikkfy qylkinipid vlpnkiewii 721 nmkegllffa drkfiklgkv dgggwqtltl ldniekiidv irdeifvvqg hnyvvysled 781 lwddkkplvs ipieedlypi sttpetatth tlhcifnarf sklvvkhqiy ldqlilakle 841 dntdledish nyrflkpykf alekilstki lrsdslddil klikmydntd pehnisppth 901 sgmleiisnc lrkietkywn hlftnlkmtp rdllalciee neakmlgvll lvflnydekd 961 lgddlhfkks dlgteeskal ndnstkksek svtnllkdee lmlkvlellv tsaanatdpi 1021 katdswdmcf qlirllkeld renntqlvqk alerfk // LOCUS NP_013141 224 aa linear PLN 30-JUN-2025 DEFINITION Afb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013141 VERSION NP_013141.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181927.1 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09359. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..224 /product="Afb1p" /calculated_mol_wt="24331" CDS 1..224 /gene="AFB1" /locus_tag="YLR040C" /coded_by="NM_001181927.1:1..675" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:24121774]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:24121774]" /note="MATalpha-specific a-factor blocker; contributes to mating efficiency under certain conditions; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W" /db_xref="GeneID:850730" /db_xref="SGD:S000004030" ORIGIN 1 mifapsfsli knillvsfli shsfaaktlt sssnddtlar saaadadmaf fmeflndfdt 61 afpqytsymm qnhltlpqpv adyyyhmvdl astadlqsdi aqsfpftqfq tfitafpwyt 121 sllnkasatt iylpqhfitg eteatmtnss yasqknsvsn svpfstanag qsmismanee 181 nsttalisas nssstsrtsq sqngahaksl yfpmalfgif aval // LOCUS NP_013143 161 aa linear PLN 30-JUN-2025 DEFINITION Nfg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013143 VERSION NP_013143.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181929.1 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09360. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..161 /product="Nfg1p" /calculated_mol_wt="16819" CDS 1..161 /gene="NFG1" /locus_tag="YLR042C" /coded_by="NM_001181929.1:1..486" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0060258 negative regulation of filamentous growth [PMID:32665277]" /note="Negative regulator of the filamentous growth pathway; inhibits invasive growth by dampening the activity of the filamentous MAPK pathway; localizes to the cell wall and to the vacuole and cell periphery in HTP studies; deletion improves xylose fermentation in industrially engineered strains; nonessential gene" /db_xref="GeneID:850731" /db_xref="SGD:S000004032" ORIGIN 1 mkisqfgsla fapivllqlf ivqaqlltds naqdlntalg qkvqytfldt gnsndqllhl 61 psttsssiit gslaaanftg ssssssipkv tssvitsiny qssnstvvtq ftplpsssrn 121 etkssqttnt issststggv gsvkpclyfv lmletiaylf s // LOCUS NP_013144 103 aa linear PLN 30-JUN-2025 DEFINITION thioredoxin TRX1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013144 VERSION NP_013144.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181930.1 REFERENCE 1 (residues 1 to 103) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 103) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 103) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 103) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09361. Method: conceptual translation. FEATURES Location/Qualifiers source 1..103 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..103 /product="thioredoxin TRX1" /calculated_mol_wt="11104" Region 6..103 /region_name="thioredoxin" /note="TIGR01068" /db_xref="CDD:200072" Site order(30,33) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239245" CDS 1..103 /gene="TRX1" /locus_tag="YLR043C" /gene_synonym="LMA1" /coded_by="NM_001181930.1:1..312" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:8603912]" /experiment="EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9813082]" /experiment="EXISTENCE:direct assay:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9813082]" /experiment="EXISTENCE:direct assay:GO:0015036 disulfide oxidoreductase activity [PMID:19362171]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:9657146]" /experiment="EXISTENCE:direct assay:GO:0080058 protein deglutathionylation [PMID:20074363]" /experiment="EXISTENCE:genetic interaction:GO:0045454 cell redox homeostasis [PMID:22561702]" /experiment="EXISTENCE:genetic interaction:GO:0080058 protein deglutathionylation [PMID:20074363]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:9015301|PMID:8603912]" /experiment="EXISTENCE:physical interaction:GO:0005829 cytosol [PMID:9159115]" /note="Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system that protects cells from oxidative and reductive stress; subunit of the LMA1 complex, with Pbi2p, that promotes vacuole inheritance; cofactor for Tsa1p; required for ER-Golgi transport; facilitates mitochondrial import of small Tims (Tim9p, Tim10p, Tim13p) by maintaining them in reduced form along with Trx2p; component of a signal transduction redox relay in a light sensing pathway; abundance increases under DNA replication stress" /db_xref="GeneID:850732" /db_xref="SGD:S000004033" ORIGIN 1 mvtqfktase fdsaiaqdkl vvvdfyatwc gpckmiapmi ekfseqypqa dfykldvdel 61 gdvaqknevs amptlllfkn gkevakvvga npaaikqaia ana // LOCUS NP_013145 563 aa linear PLN 30-JUN-2025 DEFINITION indolepyruvate decarboxylase 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013145 VERSION NP_013145.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181931.1 REFERENCE 1 (residues 1 to 563) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 563) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 563) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 563) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09362. Method: conceptual translation. FEATURES Location/Qualifiers source 1..563 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..563 /product="indolepyruvate decarboxylase 1" /EC_number="4.1.1.43" /EC_number="4.1.1.72" /EC_number="4.1.1.74" /calculated_mol_wt="61364" Region 1..554 /region_name="PDC1" /note="TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]; COG3961" /db_xref="CDD:443161" CDS 1..563 /gene="PDC1" /locus_tag="YLR044C" /coded_by="NM_001181931.1:1..1692" /experiment="EXISTENCE:direct assay:GO:0004737 pyruvate decarboxylase activity [PMID:2404950|PMID:23423327]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:16850348]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:2665820]" /experiment="EXISTENCE:direct assay:GO:0019655 glycolytic fermentation to ethanol [PMID:2404950]" /experiment="EXISTENCE:genetic interaction:GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0006559 L-phenylalanine catabolic process [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0006569 L-tryptophan catabolic process [PMID:12499363]" /experiment="EXISTENCE:mutant phenotype:GO:0047433 branched-chain-2-oxoacid decarboxylase activity [PMID:9546164]" /note="Major of three pyruvate decarboxylase isozymes; key enzyme in alcoholic fermentation; decarboxylates pyruvate to acetaldehyde; involved in amino acid catabolism; subject to glucose-, ethanol-, and autoregulation; activated by phosphorylation in response to glucose levels; N-terminally propionylated in vivo; protein tyrosine nitration on Tyr157 or Tyr344 inhibits activity and impairs fermentation" /db_xref="GeneID:850733" /db_xref="SGD:S000004034" ORIGIN 1 mseitlgkyl ferlkqvnvn tvfglpgdfn lslldkiyev egmrwagnan elnaayaadg 61 yarikgmsci ittfgvgels alngiagsya ehvgvlhvvg vpsisaqakq lllhhtlgng 121 dftvfhrmsa nisettamit diatapaeid rcirttyvtq rpvylglpan lvdlnvpakl 181 lqtpidmslk pndaesekev idtilalvkd aknpvilada ccsrhdvkae tkklidltqf 241 pafvtpmgkg sideqhpryg gvyvgtlskp evkeavesad lilsvgalls dfntgsfsys 301 yktknivefh sdhmkirnat fpgvqmkfvl qkllttiada akgykpvavp artpanaavp 361 astplkqewm wnqlgnflqe gdvviaetgt safginqttf pnntygisqv lwgsigfttg 421 atlgaafaae eidpkkrvil figdgslqlt vqeistmirw glkpylfvln ndgytiekli 481 hgpkaqynei qgwdhlsllp tfgakdyeth rvattgewdk ltqdksfndn skirmieiml 541 pvfdapqnlv eqakltaatn akq // LOCUS NP_013146 888 aa linear PLN 30-JUN-2025 DEFINITION Stu2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013146 VERSION NP_013146.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181932.1 REFERENCE 1 (residues 1 to 888) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 888) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 888) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 888) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09363. Method: conceptual translation. FEATURES Location/Qualifiers source 1..888 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..888 /product="Stu2p" /calculated_mol_wt="100788" Region <655..888 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" CDS 1..888 /gene="STU2" /locus_tag="YLR045C" /coded_by="NM_001181932.1:1..2667" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11511347|PMID:11553724]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:9606209]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:11511347]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11511347]" /experiment="EXISTENCE:direct assay:GO:0046785 microtubule polymerization [PMID:25172511]" /experiment="EXISTENCE:direct assay:GO:0061863 microtubule plus end polymerase [PMID:25172511]" /experiment="EXISTENCE:genetic interaction:GO:0007052 mitotic spindle organization [PMID:11756468]" /experiment="EXISTENCE:mutant phenotype:GO:0007020 microtubule nucleation [PMID:33752231]" /experiment="EXISTENCE:mutant phenotype:GO:0007080 mitotic metaphase chromosome alignment [PMID:40385370]" /experiment="EXISTENCE:mutant phenotype:GO:0008017 microtubule binding [PMID:11553724]" /experiment="EXISTENCE:mutant phenotype:GO:0099606 microtubule plus-end directed mitotic chromosome migration [PMID:40385370]" /note="Microtubule polymerase of the XMAP215/Dis1 family; required for elongation of the mitotic spindle during anaphase, for spindle orientation and metaphase chromosome alignment; required for plus-end directed kinetochore movement along metaphase microtubules enabling chromosome biorientation and congression; stabilizes or destabilizes kinetochore-microtubule attachment depending on kinetochore tension; interacts with spindle pole body component Spc72p; metazoan ch-TOG/XMAP215 family member" /db_xref="GeneID:850734" /db_xref="SGD:S000004035" ORIGIN 1 msgeeevdyt tlpleerlty klwkarleay kelnqlfrns vgdisrddni qiywrdptlf 61 aqyitdsnvv aqeqaivaln slidafasss lknahnitli stwtpllvek gltssrattk 121 tqsmscilsl cgldtsitqs velvipffek klpkliaaaa ncvyelmaaf gltnvnvqtf 181 lpellkhvpq laghgdrnvr sqtmnlivei ykvtgnnsdl leeilfkklk piqvkdlhkl 241 fakvgdepss skmlfewekr elekkrsqee earkrksils ndegeyqidk dgdtlmgmet 301 dmppskqqsg vqidtfsmlp eetildklpk dfqeritssk wkdrvealee fwdsvlsqtk 361 klkstsqnys nllgiyghii qkdaniqava laaqsvelic dklktpgfsk dyvslvftpl 421 ldrtkekkps vieairkall tickyydpla ssgrnedmlk dilehmkhkt pqirmectql 481 fnasmkeekd gystlqrylk devvpiviqi vndtqpairt igfesfaili kifgmntfvk 541 tlehldnlkr kkieetvktl pnfsiasgst hstietnkqt gpmenkfllk kssvlpskrv 601 assplrndnk skvnpigsva saskpsmvaa nnksrvllts kslatpknvv anstdknekl 661 ieeykyrlqk lqndemiwtk erqsllekmn ntenykiemi kenemlreql keaqsklnek 721 niqlrskeid vnklsdrvls lenelrnmei eldrnkkrnd tnlqsmgtis sysipsstvs 781 snygvkslss alpfkeeedv rrkedvnyer rssesigdlp hrvnslnirp yrkngtgvss 841 vsddldidfn dsfaseesyk raaavtstlk ariekmkaks rregttrt // LOCUS NP_013147 270 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR046C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013147 VERSION NP_013147.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181933.1 REFERENCE 1 (residues 1 to 270) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 270) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 270) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 270) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09364. Method: conceptual translation. FEATURES Location/Qualifiers source 1..270 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..270 /product="uncharacterized protein" /calculated_mol_wt="30923" Region 40..250 /region_name="RTA1" /note="RTA1 like protein; pfam04479" /db_xref="CDD:461325" CDS 1..270 /locus_tag="YLR046C" /coded_by="NM_001181933.1:1..813" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; YLR046C has a paralog, RTA1, that arose from the whole genome duplication" /db_xref="GeneID:850735" /db_xref="SGD:S000004036" ORIGIN 1 mathtskrri hrwennelse enstiiyfpa rglmwthfpf vlgiclefvg yvlkivfins 61 psistfiaqs vllliapsly alsifmlfsk marlilmeay mlipakfstv sfvvadmigr 121 vlqavgggll sswnsrntgr iliivglfiq ifcytfltfs qlflhykmka tpskivrdsn 181 ewfqynfill agillvngrt ivrvvqflmg lqsyigqhew clyvfdtvlm fllpliflat 241 frarnlfklq dksvniqlnk lldkesvsed // LOCUS NP_013148 686 aa linear PLN 30-JUN-2025 DEFINITION putative ferric-chelate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013148 VERSION NP_013148.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181934.1 REFERENCE 1 (residues 1 to 686) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 686) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 686) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 686) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09365. Method: conceptual translation. FEATURES Location/Qualifiers source 1..686 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..686 /product="putative ferric-chelate reductase" /EC_number="1.16.1.7" /calculated_mol_wt="78818" Region 120..233 /region_name="Ferric_reduct" /note="Ferric reductase like transmembrane component; pfam01794" /db_xref="CDD:426438" Region 265..459 /region_name="NOX_Duox_like_FAD_NADP" /note="NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; cd06186" /db_xref="CDD:99783" Site order(297,320..323,336..338,342..343,346..347,409) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(320,322..323) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99783" Site 404..414 /site_type="other" /note="NAD pyrophosphate binding region [chemical binding]" /db_xref="CDD:99783" Site order(404,408..411,413) /site_type="other" /note="beta-alpha-beta stucture motif" /db_xref="CDD:99783" Site order(431..432,435) /site_type="other" /note="NADP ribose binding motif [chemical binding]" /db_xref="CDD:99783" CDS 1..686 /gene="FRE8" /locus_tag="YLR047C" /coded_by="NM_001181934.1:1..2061" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0016722 oxidoreductase activity, acting on metal ions [PMID:14534306]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:14534306]" /note="Protein with sequence similarity to iron/copper reductases; involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p" /db_xref="GeneID:850736" /db_xref="SGD:S000004037" ORIGIN 1 mnlksivswf kehlpsfdvd vdkhfrtlrv rkysqiclli sfiiicviip lmnyllltdk 61 ffkichhlkh hvfnrrswvh kthmyhkqsl qlclicfvft sffviqgang dlleitkrmg 121 risvalmppl lfltlrpspl phtlylallp lhkwisrivv lesilhtwfy lyymyindtl 181 yvkmrklpni ygvialglfl liaitsvrya rrwsyrvfyy vhyvstwlil vflhyharpg 241 isyyttlnvl iltgqivyrl hitnvtrvti vpissslsll efpltdlpkk pilpgghlri 301 niyhrnflrr ffshlipfqh pftiasipsd nlvrliirng hfplrtneky yitgafepel 361 sfiskptvpf nittkssknp frnnssalin splnflikaq rvfmcvggsg isfglpllri 421 lnfngvnvrl lwvsrdykdl evlnhfknnf egmeiyisgt egneqdieid yidyhdcaad 481 indevrsiss sgrvselgdn smlsdgnpqp tepnentall skkstlrnhh ppktsdipdi 541 naddeidfty afsrsksrkn taqgtltths sfngssvfrq pkiieppaqd pcleaapkki 601 ripagvkvff grptlgdkdy ewclqtecda etdsiqccrw anqgrdhaey lsqvwvlaag 661 prgliestkr watdgglhfh gesfal // LOCUS NP_013149 252 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS2 RPS0B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013149 VERSION NP_013149.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181935.1 REFERENCE 1 (residues 1 to 252) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 252) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 252) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 252) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09366. Method: conceptual translation. FEATURES Location/Qualifiers source 1..252 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..252 /product="40S ribosomal protein uS2 RPS0B" /calculated_mol_wt="27831" Region 1..252 /region_name="PTZ00254" /note="40S ribosomal protein SA; Provisional" /db_xref="CDD:240331" CDS 1..252 /gene="RPS0B" /locus_tag="YLR048W" /gene_synonym="NAB1B; YST2" /coded_by="NM_001181935.1:1..759" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:8626693]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:8626693]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:8626693]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /experiment="EXISTENCE:mutant phenotype:GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:8626693]" /note="Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2" /db_xref="GeneID:850737" /db_xref="SGD:S000004038" ORIGIN 1 mslpatfdlt pedaqlllaa nthlgarnvq vhqepyvfna rpdgvhvinv gktweklvla 61 ariiaaipnp edvvaissrt ygqravlkfa ahtgatpiag rftpgsftny itrsfkeprl 121 vivtdprlda qaikeasyvn ipvialtdld spsefvdvai pcnnrgkhsi gliwyllare 181 vlrlrgalvd rtqpwsimpd lyfyrnpeev eqvaeeaaaa eegeeeevke evtegqaeat 241 ewaeenadnv ew // LOCUS NP_013150 428 aa linear PLN 30-JUN-2025 DEFINITION Mlo50p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013150 VERSION NP_013150.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181936.1 REFERENCE 1 (residues 1 to 428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 428) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09367. Method: conceptual translation. FEATURES Location/Qualifiers source 1..428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..428 /product="Mlo50p" /calculated_mol_wt="49362" CDS 1..428 /gene="MLO50" /locus_tag="YLR049C" /coded_by="NM_001181936.1:1..1287" /note="Mitochondrial hypothetical protein" /db_xref="GeneID:850738" /db_xref="SGD:S000004039" ORIGIN 1 mvnnimheyv ppsqrlfhsr hritrndlke ealhsgttdw ttildttidk dtnlisyavp 61 iidnfaipra nsqgspvaps pnhrstmyss ssssassvfs dglftpnnnr nssgssslvi 121 rpqknlsvds liqenkrkin sekeslslia nnndetlcth tdpsiqnlik setkrnilnl 181 kfqnrnlfrr elklekfwsn lrschtsgde tdlllviskh nlywfgipnd frlpiykrcl 241 yhyseldeag ffsqyannsl ylairkccnn eeqetlsrsi finltknvtw lnsrfddnkd 301 nknsytvteg kfyqdfpnly yhlkdklkln vimdfikpvi rnfmtnalnk hkldgiglel 361 ldilivttyy gpnkinaflm dtfilnllkq chykffvsni selviqiski dcdlvilled 421 lrsridld // LOCUS NP_013151 161 aa linear PLN 30-JUN-2025 DEFINITION Ema19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013151 VERSION NP_013151.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181937.1 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09368. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..161 /product="Ema19p" /calculated_mol_wt="18958" Region 39..156 /region_name="EBP" /note="EXPERA (EXPanded EBP superfamily); pfam05241" /db_xref="CDD:461600" CDS 1..161 /gene="EMA19" /locus_tag="YLR050C" /coded_by="NM_001181937.1:1..486" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:30213914|PMID:33596095]" /note="Integral ER membrane protein involved in protein sorting; component of ER-SURF, a pathway involved in retrieving mitochondrial membrane protein precursors and rerouting them to the mitochondrial translocation system; promotes the proteolytic degradation of non-productive mitochondrial precursor proteins suggesting involvement in quality control during protein import; GFP-fusion protein localizes to the ER; member of a conserved family of ER proteins including human homolog TMEM97" /db_xref="GeneID:850739" /db_xref="SGD:S000004040" ORIGIN 1 mklghreqqf ylwyfivhip itifidssvv ipakwqlgia qkvvsdhiak qhdfllsekp 61 ewlywfvvle lvlqlplfvy fvnkfwnsse lqvntnsrlk kwlriygwna slttlicivv 121 ifkrgyipyd vlktslsmtq kcqlasvylp tfliplrlcf v // LOCUS NP_013152 217 aa linear PLN 30-JUN-2025 DEFINITION Fcf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013152 VERSION NP_013152.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181938.1 REFERENCE 1 (residues 1 to 217) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 217) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 217) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 217) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09369. Method: conceptual translation. FEATURES Location/Qualifiers source 1..217 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..217 /product="Fcf2p" /calculated_mol_wt="25505" Region 102..190 /region_name="Fcf2" /note="Fcf2 pre-rRNA processing; pfam08698" /db_xref="CDD:462566" CDS 1..217 /gene="FCF2" /locus_tag="YLR051C" /coded_by="NM_001181938.1:1..654" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:14690591]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16762320]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16762320]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16762320]" /note="Nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon; essential gene" /db_xref="GeneID:850740" /db_xref="SGD:S000004041" ORIGIN 1 mdqsvedlfg alrdasasle vknsakeqvs lqqedvlqig nnddeveies kfqeietnlk 61 klpkletgfd alankkkkkn vlpsvetedk rkpnksdknd ndwftlpkpd dnmrrevqrd 121 lllikhraal dpkrhykkqr wevperfaig tiiedksefy ssrmnrkerk stiletlmgd 181 easnkyfkrk yneiqeksts grkahykkmk emrkkrr // LOCUS NP_013153 250 aa linear PLN 30-JUN-2025 DEFINITION Ies3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013153 VERSION NP_013153.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181939.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09370. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..250 /product="Ies3p" /calculated_mol_wt="28112" CDS 1..250 /gene="IES3" /locus_tag="YLR052W" /coded_by="NM_001181939.1:1..753" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12887900]" /experiment="EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:12887900]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:17562861]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:17562861]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Subunit of the INO80 chromatin remodeling complex" /db_xref="GeneID:850741" /db_xref="SGD:S000004042" ORIGIN 1 mkfedllatn kqvqfahaat qhyksvktpd flekdphhkk fhnadglnqq gsstpstatd 61 anaastasth tntttfkrhi vavddiskmn yemiknspgn vitnanqdei distlktrly 121 kdnlyamndn flqavndqiv tlnaaeqdqe tedpdlsdde kidiltkiqe nlleeyqkls 181 qkerkwfilk ellldanvel dlfsnrgrka shpiafgava iptnvnansl afnrtkrrki 241 nkngllenil // LOCUS NP_013154 108 aa linear PLN 30-JUN-2025 DEFINITION Nrs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013154 VERSION NP_013154.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181940.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09371. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..108 /product="Nrs1p" /calculated_mol_wt="12562" CDS 1..108 /gene="NRS1" /locus_tag="YLR053C" /coded_by="NM_001181940.1:1..327" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:35239649]" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:35239649]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:35239649]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:35239649]" /experiment="EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:35239649]" /experiment="EXISTENCE:expression pattern:GO:0006995 cellular response to nitrogen starvation [PMID:35239649]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:35239649]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:35239649]" /experiment="EXISTENCE:physical interaction:GO:0044877 protein-containing complex binding [PMID:35239649]" /note="Nitrogen-responsive activator of Start; nuclear microprotein with transcriptional activator activity; bypasses Start arrest in a cln3 bck2 double mutant when overexpressed; interacts with subunits of the SBF complex (Swi4p-Swi6p); induced by nitrogen limitation and rapamycin with peak abundance at Start; proposed to promote the G1/S transition by rewiring the G1/S transcriptional machinery under poor nitrogen conditions upstream of the Whi5-inhibited form of SBF and independent of Cln3 and Bck2" /db_xref="GeneID:850742" /db_xref="SGD:S000004043" ORIGIN 1 mdmlhnkcsd aikstsnsnl snevdkqklq yddlgntgfs elfemesqdn ndsiedflff 61 ninltqevef enqrqyehtk ktkkhnpfyv psevvremvk khalngri // LOCUS NP_013155 724 aa linear PLN 30-JUN-2025 DEFINITION Osw2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013155 VERSION NP_013155.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181941.1 REFERENCE 1 (residues 1 to 724) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 724) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 724) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 724) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09372. On Oct 2, 2003 this sequence version replaced NP_013155.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..724 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..724 /product="Osw2p" /calculated_mol_wt="82197" CDS 1..724 /gene="OSW2" /locus_tag="YLR054C" /coded_by="NM_001181941.1:1..2175" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:15590821]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141|PMID:15590821]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]" /note="hypothetical protein reputedly involved in spore wall assembly" /db_xref="GeneID:850743" /db_xref="SGD:S000004044" ORIGIN 1 meenqltcli vgetpaaqfl gwrlslsnsf iilvsqyvss delvawkstk lganfytpni 61 ltkdikelhh klkhnganty sidivlvsai slqsfettcr llsdytndnt tvlistdfgc 121 elepiaisyf ggkckcvisi scevecrqls lgsyalvndd qcvitlglty cdanfeaspt 181 ilentkaasl elqgikgsnv rrfllgltva kwmksklild pkqmalkmwe llipkislni 241 lsiiyeqfdy ekmlenkste iifkdlvkel lgicfaqcgs kiarfllvks qgeeeinfgk 301 iveyckgkkl qlinstaneh peylslpfep ycfyhrfeyp aqillhqpii lakkygvscs 361 nlnflygfyt rlltlsglsi nggrcehals mldsrigggi nvasginsgq dftdgdnedq 421 dkgknrvdkn vkegsfislt qrftmtsplg vndpalpadl eklylgaeyi sncdantsgg 481 qkrvksptka dtgyddkhlp ddtihtfede yladeddfsc lgidkrsstk ptkplekfgv 541 vavphfirrf sikrsskdks ndmkrpytts slelqlrsnh fmfakeyqdl hrqlyyevkp 601 rtqseldarr rnyselesqm wkikhrfnih rgalprprtn pyellldhid vlnrgntgdi 661 lrfttsrygg vdtydsilrd qstimelldk rcaysppvlf dneakerdhd rdcyqdynhd 721 hrsh // LOCUS NP_013156 602 aa linear PLN 30-JUN-2025 DEFINITION SAGA complex subunit SPT8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013156 VERSION NP_013156.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181942.1 REFERENCE 1 (residues 1 to 602) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 602) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 602) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 602) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09373. Method: conceptual translation. FEATURES Location/Qualifiers source 1..602 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..602 /product="SAGA complex subunit SPT8" /calculated_mol_wt="66059" Region 178..>355 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 180..218 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 264..302 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 304..593 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(306,324,328,334..335,347..348,372,381,387,407, 419..420,433,438,444..445,460,479,484,490..491,504..505, 525,529,534..535,559..560,578,583,586..587) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 310..346 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 353..408 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 362..457 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 464..503 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 511..558 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..602 /gene="SPT8" /locus_tag="YLR055C" /coded_by="NM_001181942.1:1..1809" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10611242]" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:15132995]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10611242]" /experiment="EXISTENCE:mutant phenotype:GO:0003712 transcription coregulator activity [PMID:9858534]" /experiment="EXISTENCE:mutant phenotype:GO:0017025 TBP-class protein binding [PMID:9858534]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12370284]" /note="Subunit of the SAGA transcriptional regulatory complex; not present in SAGA-like complex SLIK/SALSA; required for SAGA-mediated inhibition at some promoters" /db_xref="GeneID:850744" /db_xref="SGD:S000004045" ORIGIN 1 mdevddilin nqvvddeedd eemlsglend skqdlegndd ggedeedddd ddeddddded 61 eredddeqed ddgeddaarm dktatptneh qhdeqkaaaa gaggagdsgd avtkigsedv 121 klsdvdggvg sreasssthe asangevyey ykhmlnaaqi adsyniypta aipiqthvna 181 lavsrglkyl flggsdgyir kydllntleg klsltilqkh slaesiqnag ilqsywenei 241 pqkksemkls anktdyepkv spvhslevqs eclfilsglq nggitmqgvr ymegsiahyf 301 kgrnghtqiv nilrlngqed rflsgswdkr llewdlqtgd ivnefkksrs elsslemrpl 361 yssvdvsgnv nsgkenenad ddmdslfgde dedekqdagn epvetgdgsn geenkeqise 421 eslnivydes vfmtsglngs vhiwdrrmtq spalslerga gvppwclsac wgvdgdhvya 481 grrnacveqf dlkmpskpih nlklpsisgp vscvkampnn khllcasrdn irlynveiav 541 dasnsttkss kvpflivpgh hggiisnlyl dptsrfiist sgnrgwqgns tdttliydid 601 le // LOCUS NP_013157 365 aa linear PLN 30-JUN-2025 DEFINITION C-5 sterol desaturase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013157 VERSION NP_013157.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181943.1 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09374. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..365 /product="C-5 sterol desaturase" /EC_number="1.14.19.20" /calculated_mol_wt="42599" Region 188..312 /region_name="FA_hydroxylase" /note="Fatty acid hydroxylase; pfam04116" /db_xref="CDD:397991" CDS 1..365 /gene="ERG3" /locus_tag="YLR056W" /gene_synonym="PSO6; SYR1" /coded_by="NM_001181943.1:1..1098" /experiment="EXISTENCE:direct assay:GO:0000248 C-5 sterol desaturase activity [PMID:34600]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:21737688]" /experiment="EXISTENCE:mutant phenotype:GO:0000248 C-5 sterol desaturase activity [PMID:1864507]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:1864507]" /note="C-5 sterol desaturase; glycoprotein that catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutants are viable, but cannot grow on non-fermentable carbon sources; substrate of HRD ubiquitin ligase; mutation is functionally complemented by human SC5D" /db_xref="GeneID:850745" /db_xref="SGD:S000004046" ORIGIN 1 mdlvlevadh yvlddlyakv lpaslaanip vkwqkllgln sgfsnstilq etlnsknavk 61 ecrrfygqvp flfdmsttsf asllprssil reflslwviv tifglllylf taslsyvfvf 121 dksifnhpry lknqmameik lavsaipwms mltvpwfvme lnghsklymk idyenhgvrk 181 liieyftfif ftdcgvylah rwlhwprvyr alhkphhkwl vctpfashsf hpvdgflqsi 241 syhiyplilp lhkvsylilf tfvnfwtvmi hdgqylsnnp avngtachtv hhlyfnynyg 301 qfttlwdrlg gsyrrpddsl fdpklrdake twdaqvkeve hfikevegdd ndriyendpn 361 tkknn // LOCUS NP_013158 849 aa linear PLN 30-JUN-2025 DEFINITION putative mannosidase MNL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013158 VERSION NP_013158.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181944.1 REFERENCE 1 (residues 1 to 849) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 849) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 849) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 849) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09375. Method: conceptual translation. FEATURES Location/Qualifiers source 1..849 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..849 /product="putative mannosidase MNL2" /calculated_mol_wt="96867" Region 197..848 /region_name="Glyco_hydro_47" /note="Glycosyl hydrolase family 47; pfam01532" /db_xref="CDD:460241" CDS 1..849 /gene="MNL2" /locus_tag="YLR057W" /coded_by="NM_001181944.1:1..2550" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:21971548]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:21971548]" /note="Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene" /db_xref="GeneID:850746" /db_xref="SGD:S000004047" ORIGIN 1 msiarlvysl frrvrsvlll fitisllfyy tfqneidiln syalndslps innyehnteg 61 sskldppdls stgsdriatd kengnvavdl sdpatlrekn kyfplllkgs shqigsnlpi 121 sslltykeky pvlfeyssps ltsisqndvh kiqpamqlpp dvdmikqikd ifmkswnqeq 181 lllksnlrre stwpidlids ldtlylcget klfqdsvnii edfdfrvppl amevidipdi 241 ttrvleglls ayelsmdkrl lnkakhvadf ilrsfdtpnr ipilkyfwks dlrnrfpdrt 301 vpsgqlttma lafirlsqlt rlnkyfdave rvfttirqsy nefdmefmlp dvvdasgcql 361 ltqeeienga hlkgssimks inenfkfvhc qqlgkflnpp iddnslqeqs qyqayrinek 421 tvpilenlfk indlfqssyd ildgssknan aatmdpsigs eveavdeiie krnfkdgtkk 481 dstkntvgdk slidsqtflt nsisnifkfm tfrpmlpkqt enkkfnflns iltksqfmpt 541 tneldvtirk sydvslyscr lggilglssr vphrggvntk yilpssllem seiitescfm 601 lmeefdgllp qkfeldpctd etngncefng etksrmiang eyetfendld vgikvsnygk 661 ggndqkakrn vlskdgitet qnikgdtvgs sksiaeidgd evtqirrvft lgkdikphit 721 tddtmgsqwk nhpdwpfwvn kvesrrllds niiesifymy risgeqkwrs mgkqsfgilm 781 qelmelnsga kglwqikefy engekvnndl psywfsrtlk yylllfsdgd kvsldkhilt 841 qgghiikkk // LOCUS NP_013159 469 aa linear PLN 30-JUN-2025 DEFINITION glycine hydroxymethyltransferase SHM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013159 VERSION NP_013159.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181945.1 REFERENCE 1 (residues 1 to 469) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 469) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 469) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 469) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09376. Method: conceptual translation. FEATURES Location/Qualifiers source 1..469 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..469 /product="glycine hydroxymethyltransferase SHM2" /EC_number="2.1.2.1" /calculated_mol_wt="52088" Region 17..416 /region_name="SHMT" /note="Serine hydroxymethyltransferase; pfam00464" /db_xref="CDD:395372" Site order(21,23,30..31,40,45,63,81..82,90,109,116,156..157,296, 314) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:99733" Site order(44,64,74,111..112,139,194,219,222,247..248,254,393) /site_type="other" /note="glycine-pyridoxal phosphate binding site [chemical binding]" /db_xref="CDD:99733" Site order(44,139,248,393) /site_type="active" /db_xref="CDD:99733" Site order(66,73,134,138,140,288,378) /site_type="other" /note="folate binding site [chemical binding]" /db_xref="CDD:99733" CDS 1..469 /gene="SHM2" /locus_tag="YLR058C" /gene_synonym="SHMT2" /coded_by="NM_001181945.1:1..1410" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12700234]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:mutant phenotype:GO:0004372 glycine hydroxymethyltransferase activity [PMID:8132653|PMID:9398220]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:8132653]" /experiment="EXISTENCE:mutant phenotype:GO:0006730 one-carbon metabolic process [PMID:9398220|PMID:8132653]" /note="Cytosolic serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis" /db_xref="GeneID:850747" /db_xref="SGD:S000004048" ORIGIN 1 mpytlsdahh klitshlvdt dpevdsiikd eierqkhsid liasenftst svfdalgtpl 61 snkysegypg aryyggnehi drmeilcqqr alkafhvtpd kwgvnvqtls gspanlqvyq 121 aimkpherlm glylpdgghl shgyatenrk isavstyfes fpyrvnpetg iidydtlekn 181 ailyrpkvlv agtsaycrli dykrmreiad kcgaylmvdm ahisgliaag vipspfeyad 241 ivtttthksl rgprgamiff rrgvrsinpk tgkevlydle npinfsvfpg hqggphnhti 301 aalatalkqa atpefkeyqt qvlknakale sefknlgyrl vsngtdshmv lvslrekgvd 361 garveyicek inialnknsi pgdksalvpg gvrigapamt trgmgeedfh rivqyinkav 421 efaqqvqqsl pkdacrlkdf kakvdegsdv lntwkkeiyd wageyplav // LOCUS NP_013160 269 aa linear PLN 30-JUN-2025 DEFINITION Rex2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013160 VERSION NP_013160.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181946.1 REFERENCE 1 (residues 1 to 269) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 269) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 269) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 269) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09377. Method: conceptual translation. FEATURES Location/Qualifiers source 1..269 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..269 /product="Rex2p" /calculated_mol_wt="30739" Region 55..235 /region_name="Orn" /note="DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; cd06135" /db_xref="CDD:99838" Site order(59..62,64,162..163,165..167,214,219) /site_type="active" /note="putative active site [active]" /db_xref="CDD:99838" Site order(59..62,64,162..163,165..166,214,219) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:99838" Site order(59,61,167,214,219) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:99838" Site order(82,165..166,169,172,185..186,188,191,194,199..200, 232,234..235) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:99838" CDS 1..269 /gene="REX2" /locus_tag="YLR059C" /gene_synonym="YNT20" /coded_by="NM_001181946.1:1..810" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:9933355|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:9933355]" /experiment="EXISTENCE:genetic interaction:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10716935]" /experiment="EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:10716935]" /experiment="EXISTENCE:genetic interaction:GO:0034476 U5 snRNA 3'-end processing [PMID:10716935]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:9933355]" /experiment="EXISTENCE:mutant phenotype:GO:0000175 3'-5'-RNA exonuclease activity [PMID:10716935]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9933355]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10716935]" /note="3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease; role in preventing L-A mycovirus pathogenesis" /db_xref="GeneID:850748" /db_xref="SGD:S000004049" ORIGIN 1 mkwllfpari vartrpnlfs lyrrsvsqyl rprtiqnlqs maqtpelktk lfkplvwidc 61 emtgldhvnd riieicciit dghlapvkaa dgqgdshyes vihygpevmn kmnewciehh 121 gnsgltakvl asektlaqve delleyiqry ipdknvgvla gnsvhmdrlf mvrefpkvid 181 hlfyrivdvs simevarrhn palqarnpkk eaahtaysdi kesiaqlqwy mdnylkppqe 241 tesvesigse qpespsssts slkrqrtdf // LOCUS NP_013161 595 aa linear PLN 30-JUN-2025 DEFINITION phenylalanine--tRNA ligase subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_013161 VERSION NP_013161.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181947.1 REFERENCE 1 (residues 1 to 595) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 595) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 595) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 595) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 595) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 595) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 595) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 595) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 595) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09378. Method: conceptual translation. FEATURES Location/Qualifiers source 1..595 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..595 /product="phenylalanine--tRNA ligase subunit beta" /EC_number="6.1.1.20" /calculated_mol_wt="67234" Region 1..595 /region_name="pheT_arch" /note="phenylalanyl-tRNA synthetase, beta subunit; TIGR00471" /db_xref="CDD:273096" CDS 1..595 /gene="FRS1" /locus_tag="YLR060W" /coded_by="NM_001181947.1:1..1788" /experiment="EXISTENCE:direct assay:GO:0004826 phenylalanine-tRNA ligase activity [PMID:16162501|PMID:166841]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006432 phenylalanyl-tRNA aminoacylation [PMID:16162501|PMID:166841]" /experiment="EXISTENCE:direct assay:GO:0009328 phenylalanine-tRNA ligase complex [PMID:3049607]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase; forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control" /db_xref="GeneID:850749" /db_xref="SGD:S000004050" ORIGIN 1 mptvsvnkqq lfdllgknyt sqefdelcfe fgmemdedtt eealktgeep elkldisanr 61 ydllciegis qslneylerk erpdyklskp ttkliidkst eqirpfataa vlrniklnek 121 syasfialqd klhanlcrnr slvamgthdl dsiegpfhyr alppkdikfv plnqtqeftg 181 dkliefyksp eqknnigryv hiiedspvfp vimdskdrvc slpplinseh skisvntrni 241 liditatdkt kaeivlnilt tmfsrycdep ftvepveivs ehngqsrlap nfndrimdvs 301 ikyinsclgl dqsadeiahc lkkmslhavq skedkdilhv dipvtrpdil hacdimedaa 361 vgygfnnlpk geklsnanfi akplpinkvs difrvassqa twvevlpltl cshdenfkfl 421 rqsdngdlav klanpktley qvvrttllpg ilktvkenrk hslpikvfet gdvvfkddkl 481 erkaynerhw aaiyvgknsg feiiqgllgk imqtfrtewi adygaaasgr gywieeddsv 541 ktyfpgrgak vmfrskegae pkqighlgvl hpevmmnfdv pfaasfvevn aevfl // LOCUS NP_013162 121 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL22 RPL22A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013162 VERSION NP_013162.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181948.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09379. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..121 /product="60S ribosomal protein eL22 RPL22A" /calculated_mol_wt="13562" Region 15..110 /region_name="Ribosomal_L22e" /note="Ribosomal L22e protein family; pfam01776" /db_xref="CDD:460321" CDS 1..121 /gene="RPL22A" /locus_tag="YLR061W" /coded_by="NM_001181948.1:1..366" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:27478489]" /note="Ribosomal 60S subunit protein L22A; required for translation of long 5' UTR of IME1 mRNA and meiotic entry; required for the oxidative stress response, pseudohyphal and invasive growth; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication" /db_xref="GeneID:850750" /db_xref="SGD:S000004051" ORIGIN 1 mapntsrkqk iaktftvdvs sptengvfdp asyakylidh ikvegavgnl gnavtvtedg 61 tvvtvvstak fsgkylkylt kkylkknqlr dwirfvstkt neyrlafyqv tpeedeeede 121 e // LOCUS NP_013164 365 aa linear PLN 30-JUN-2025 DEFINITION 25S rRNA (uracil2843-N3)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013164 VERSION NP_013164.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181950.1 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09380. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..365 /product="25S rRNA (uracil2843-N3)-methyltransferase" /EC_number="2.1.1.312" /calculated_mol_wt="41910" Region 76..362 /region_name="Methyltransf_34" /note="Putative SAM-dependent methyltransferase; pfam11312" /db_xref="CDD:431804" CDS 1..365 /gene="BMT6" /locus_tag="YLR063W" /coded_by="NM_001181950.1:1..1098" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:24335083]" /experiment="EXISTENCE:mutant phenotype:GO:0070042 rRNA (uridine-N3-)-methyltransferase activity [PMID:24335083]" /experiment="EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:24335083]" /note="Methyltransferase required for m3U2843 methylation of the 25S rRNA; S-adenosylmethionine-dependent; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene" /db_xref="GeneID:850752" /db_xref="SGD:S000004053" ORIGIN 1 mllmrrfafl tssvyfkyip iysqyhyssq fpinmnpkkv aqlpvhnkst lppqeiidlf 61 kitfleelyp kdqdnekspl teqiqavksd lynrdynaaf nndskriayc crwspsrats 121 yasvfahfpe llkiirceid dkdsnvlcig ggaggelval asiftlsrdf sskfasalki 181 dnevnkkprn lniqlvdiad wstvveklta tikskwlygd seaesfnvnf thkdclqmte 241 pqdikiyqgl dlitllfttn elftqkkves ikflqrlnen capgchllil esagsyshit 301 innkkfpiqf lidtilvgnr kdkgttgpws lvsendsiwy rmdpkldysi plenmrffyr 361 lyvkn // LOCUS NP_013165 273 aa linear PLN 30-JUN-2025 DEFINITION Per33p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013165 VERSION NP_013165.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181951.1 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09381. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..273 /product="Per33p" /calculated_mol_wt="32506" Region 24..264 /region_name="TMEM33_Pom33" /note="Transmembrane protein 33/Nucleoporin POM33; pfam03661" /db_xref="CDD:461009" CDS 1..273 /gene="PER33" /locus_tag="YLR064W" /coded_by="NM_001181951.1:1..822" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:20498018]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20498018|PMID:14562095|PMID:26928762]" /note="Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850753" /db_xref="SGD:S000004054" ORIGIN 1 mtvprnrpma pfgtiiksri kqpqfywfig hfltifnfiq fhlsitskqn qlscyrrslf 61 yisvtyaivl yqffksdqlk fnftllrqem kkldnlqyfa mlfilfllsq fniiisgsly 121 spvifsifhf lnyfkenllp flpliplnlk nllnskitvf iqnyngfflq maqvfeiicg 181 lrvglflvpf nfflllvrra nvsfevvgtm lagltyvwff klrylqsesm rqifkqyvlr 241 ldayvsrtlp pycsrlwngy knfvmtvfwk ipv // LOCUS NP_013166 181 aa linear PLN 30-JUN-2025 DEFINITION Snd2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013166 VERSION NP_013166.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181952.1 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09382. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..181 /product="Snd2p" /calculated_mol_wt="20610" Region 1..171 /region_name="TMEM208_SND2" /note="SRP-independent targeting protein 2/TMEM208; pfam05620" /db_xref="CDD:428546" CDS 1..181 /gene="SND2" /locus_tag="YLR065C" /gene_synonym="ENV10" /coded_by="NM_001181952.1:1..546" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:21912603]" /note="Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Pho88p/Snd3p and Sec61p-translocon subunits; can compensate for loss of SRP; role in the late endosome-vacuole interface; putative role in secretory protein quality control" /db_xref="GeneID:850754" /db_xref="SGD:S000004055" ORIGIN 1 magkagrkqa ssnakiiqgl ykqvslflgm aivrlfisrk vtigqwiklv alnvpmfval 61 yiivlsgkpk ydgnrvvkqg idlndntnli syffdliyls lfgnigiiaf rtfkfwwcll 121 lcpiyagykl yglknmfmpg aqqtqadnrs knanegqsks krqmkrerrg etdskikyky 181 r // LOCUS NP_013167 184 aa linear PLN 30-JUN-2025 DEFINITION signal peptidase complex subunit SPC3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013167 VERSION NP_013167.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181953.1 REFERENCE 1 (residues 1 to 184) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 184) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 184) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 184) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09383. Method: conceptual translation. FEATURES Location/Qualifiers source 1..184 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..184 /product="signal peptidase complex subunit SPC3" /calculated_mol_wt="21218" Region 1..177 /region_name="SPC22" /note="Signal peptidase subunit; pfam04573" /db_xref="CDD:461357" CDS 1..184 /gene="SPC3" /locus_tag="YLR066W" /coded_by="NM_001181953.1:1..555" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005787 signal peptidase complex [PMID:8910564|PMID:1846444]" /experiment="EXISTENCE:direct assay:GO:0006465 signal peptide processing [PMID:9148931]" /experiment="EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:9148930|PMID:9148931]" /experiment="EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:9148931]" /note="Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23; other members of the complex are Spc1p, Spc2p, and Sec11p" /db_xref="GeneID:850755" /db_xref="SGD:S000004056" ORIGIN 1 mfsfvqrfqn vsnqafsmgi vmvvfimass yyqlinnnaf svpsnidnvk tlinvrtsry 61 fgsqrgkake nmkikfdlnt dltplfnwnt kqvfvyltae ynstekitse vtfwdkiiks 121 kddavidvnd lrskysiwdi edgkfegkdl vfklhwnvqp wvglltyget vgnytltven 181 knkv // LOCUS NP_013168 965 aa linear PLN 30-JUN-2025 DEFINITION Pet309p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013168 VERSION NP_013168.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181954.1 REFERENCE 1 (residues 1 to 965) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 965) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 965) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 965) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 965) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 965) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 965) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 965) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 965) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09384. Method: conceptual translation. FEATURES Location/Qualifiers source 1..965 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..965 /product="Pet309p" /calculated_mol_wt="112515" Region 317..340 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region <345..465 /region_name="PPR_long" /note="Pentacotripeptide-repeat region of PRORP; pfam17177" /db_xref="CDD:407303" Region 348..375 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 386..410 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 416..445 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 452..480 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 488..513 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 527..554 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 560..590 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 597..623 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" CDS 1..965 /gene="PET309" /locus_tag="YLR067C" /coded_by="NM_001181954.1:1..2898" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:25181249]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9692914]" /experiment="EXISTENCE:mutant phenotype:GO:0008494 translation activator activity [PMID:7664742]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:7664742]" /experiment="EXISTENCE:mutant phenotype:GO:0070134 positive regulation of mitochondrial translational initiation [PMID:7664742]" /note="Specific translational activator for the COX1 mRNA; binds to the COX1 mRNA; also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains 12 pentatricopeptide repeats (PPRs)" /db_xref="GeneID:850756" /db_xref="SGD:S000004057" ORIGIN 1 mkrcapavlr nynykkgiws tgvpdhirkl lrdkstsplc sqdernlvsy fmargsvplk 61 svgsgltkka ttsitsnsat ttferqylik ylyrhqaygn vikiaqkfly ttigsqrllk 121 qdaslpelkk fllsllilqr giqldqaisd iiqrflltqk tmvidlinsi fsrmvimnmh 181 eeavykwvkw mklvnghcef tnymenkivl rnflsfmrqs nvrpdylsyl kaiqltqgpa 241 iasqfattll flltyirkfs saeavwnykc ehnlpivssd ltcilktych mqkfnlvsst 301 ywkypdaqhd qnqfdyllva hsrlhnwdal qqqfnalfgi gklpsiqhyg ilmytmarig 361 eldsvnklyt qllrrgmipt yavlqsllya hykvgdfaac fshfelfkky ditpstatht 421 imlkvyrgln dldgafrilk rlsedpsvei teghfalliq mcckttnhli aqelfnlmte 481 hyniqhtgks isalmdvyie snrpteaial fekhsknlsw rdglisvynk aikayiglrn 541 ankceelfdk ittsklavns efykmmikfl vtlnedceta lsiidqlikh svikvdathf 601 eiimeaydke gyrdgiinly ktmsqnkvpa nskilyyilk avakkslqnn eeiketinmv 661 edimenaang tldvtynklh psvmawpmrm ivkhdspqra lelynrynel ffkkhdwisn 721 nnkfvmmrsl lvllaqieqw kdfetlfaky mdrienienl pssttpnikl rsifsglfpy 781 kvsqliamnk idelpllwkk lrekgfildn iswnsaveal fkdprtlsyg mkivddtlih 841 gynlihkfrl ltklsedktq ssdkswptlk mkekepnkfq prlylksdty nsimrqldty 901 ldgiddlktl edqvrdfisn ykyfmkdyll mprskinkwe qiemrhlsyf kelrkskrvl 961 pvskf // LOCUS NP_013169 151 aa linear PLN 30-JUN-2025 DEFINITION Fyv7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013169 VERSION NP_013169.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181955.1 REFERENCE 1 (residues 1 to 151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 151) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09385. Method: conceptual translation. FEATURES Location/Qualifiers source 1..151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..151 /product="Fyv7p" /calculated_mol_wt="18059" Region 8..146 /region_name="rRNA_processing" /note="rRNA processing; pfam08524" /db_xref="CDD:400708" CDS 1..151 /gene="FYV7" /locus_tag="YLR068W" /coded_by="NM_001181955.1:1..456" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12837249]" /note="Nucleolar protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin" /db_xref="GeneID:850757" /db_xref="SGD:S000004058" ORIGIN 1 mgtakqnqnr kkftreykvk eiqrsitkkt rlrkeylkal kdegyavpek epktvakesv 61 rkikearaie gkkkldekke ikkqrkrmqk delnkqrneq lerirvskek fqrredrkkk 121 ltqrtrtgqp lmgpkiedll dkiktddtyt s // LOCUS NP_013170 761 aa linear PLN 30-JUN-2025 DEFINITION Mef1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013170 VERSION NP_013170.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181956.1 REFERENCE 1 (residues 1 to 761) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 761) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 761) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 761) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09386. Method: conceptual translation. FEATURES Location/Qualifiers source 1..761 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..761 /product="Mef1p" /calculated_mol_wt="84443" Region 68..759 /region_name="FusA" /note="Translation elongation factor EF-G, a GTPase [Translation, ribosomal structure and biogenesis]; COG0480" /db_xref="CDD:440248" CDS 1..761 /gene="MEF1" /locus_tag="YLR069C" /coded_by="NM_001181956.1:1..2286" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:1935960]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:1935960]" /note="Mitochondrial elongation factor involved in translational elongation" /db_xref="GeneID:850758" /db_xref="SGD:S000004059" ORIGIN 1 msvqkmmwvp rkmvggripf ftcskvfsgf srrsfhespl arstyeeekv lvdeikqklt 61 pddigrcnkl rnigisahid sgkttfterv lyytkrikai hevrgrdnvg akmdsmdler 121 ekgitiqsaa tycswdkegk nyhfnlidtp ghidftieve ralrvldgav lvvcavsgvq 181 sqtvtvdrqm rrynvprvtf inkmdrmgsd pfraieqlns klkipaaavq ipigsessls 241 gvvdlinrva iynkgdngei iekgpvpenl kplmeekrql lietladvdd emaemfleek 301 epttqqikda irrstiarsf tpvlmgsala ntgiqpvlda ivdylpnpse vlntaldvsn 361 neakvnlvpa vqqpfvglaf kleegkygql tyvrvyqgrl rkgnyitnvk tgkkvkvarl 421 vrmhssemed vdevgsgeic atfgidcasg dtftdgsvqy smssmyvpda vvslsitpns 481 kdasnfskal nrfqkedptf rvkfdpeske tiisgmgelh leiyvermrr eynvdcvtgk 541 pqvsyresit ipadfdythk kqsggagqyg rvigtlspvd ditkgnifet aivggripdk 601 ylaacgkgfe evcekgplig hrvldvkmli ndgaihavds nelsfktatm safrdaflra 661 qpvimepimn vsvtspnefq gnvigllnkl qaviqdteng hdeftlkaec alstmfgfat 721 slrastqgkg efslefshya ptaphvqkel isefqkkqak k // LOCUS NP_013171 356 aa linear PLN 30-JUN-2025 DEFINITION D-xylulose reductase XYL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013171 VERSION NP_013171.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181957.1 REFERENCE 1 (residues 1 to 356) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 356) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 356) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 356) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09387. Method: conceptual translation. FEATURES Location/Qualifiers source 1..356 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..356 /product="D-xylulose reductase XYL2" /EC_number="1.1.1.9" /calculated_mol_wt="38469" Region 9..354 /region_name="sorbitol_DH" /note="Sorbitol dehydrogenase; cd05285" /db_xref="CDD:176188" Site order(44,46,50,56,59,69,118,121,155,276,299..300) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:176188" Site order(44,46,69..70,155) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176188" Site order(99,102,105,113) /site_type="other" /note="structural Zn binding site [ion binding]" /db_xref="CDD:176188" Site order(159,181..183,202..204,208,223,251..252,254,274..276, 298..300) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:176188" Site order(161,172,174,190,193..195,197,206,222,238,308, 311..312,315) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:176188" CDS 1..356 /gene="XYL2" /locus_tag="YLR070C" /coded_by="NM_001181957.1:1..1071" /experiment="EXISTENCE:direct assay:GO:0005999 xylulose biosynthetic process [PMID:10486580]" /experiment="EXISTENCE:direct assay:GO:0046526 D-xylulose reductase activity [PMID:10486580]" /note="Xylitol dehydrogenase; converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect" /db_xref="GeneID:850759" /db_xref="SGD:S000004060" ORIGIN 1 mtdlttqeai vlerpgkitl tnvsipkisd pneviiqika tgicgsdihy ythgrianyv 61 vespmvlghe ssgivalige nvktlkvgdr valepgipdr fspemkegry nldpnlkfaa 121 tppfdgtltk yyktmkdfvy klpddvsfee galieplsva ihanklakik fgarcvvfga 181 gpigllagkv asvfgaadvv fvdllenkle tarqfgathi vnsgdlphgv tvdsvikkai 241 gkkgadvvfe csgaepcvra gievckaggt ivqvgmgqee iqfpisiipt keltfqgcfr 301 ycqgdysdsi elvssrklsl kpfithrysf kdaveafeet shhplnnikt iiegpe // LOCUS NP_013172 1082 aa linear PLN 30-JUN-2025 DEFINITION Rgr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013172 VERSION NP_013172.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181958.1 REFERENCE 1 (residues 1 to 1082) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1082) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1082) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1082) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1082) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1082) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1082) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1082) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1082) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09388. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1082 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1082 /product="Rgr1p" /calculated_mol_wt="123228" Region 89..292 /region_name="Med14" /note="Mediator complex subunit MED14; pfam08638" /db_xref="CDD:462543" CDS 1..1082 /gene="RGR1" /locus_tag="YLR071C" /gene_synonym="MED14" /coded_by="NM_001181958.1:1..3249" /experiment="EXISTENCE:direct assay:GO:0001093 TFIIB-class transcription factor binding [PMID:27688401]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16452140]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11470794]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation" /db_xref="GeneID:850760" /db_xref="SGD:S000004061" ORIGIN 1 mtttigspqm laneerlsne mhalknrseq ngqeqqgpvk ntqlhgpsat dpettatqke 61 slemvpkdts aatmtsappp alphveinqv slalvirnlt vftmkelaqy mktnvhtqan 121 epnsakkirf lqliiflrtq flklyvlvkw trtikqnnfh vlidllnwfr ttnmnvnnci 181 walksslnsm tnaklpnvdl vtalevlslg rpnlpthnfk lsgvsnsmdm vdgmakvpig 241 lilqrlkdln ltvsikialm nipkplnsyh ikngriyftv pnefeiqlst vnrqsplffv 301 dlkllfntea eqtvsavtea tstngdsenn eensssngnn lplnkprlek lineillksn 361 dpllslynfl hkyvltlqly mvhreflkla nggkfsksnl ihnydskkst itvrywlngk 421 mdskgkitig iqrtteslil kwdnqsasra knmpviynni vsniegilde imfnhariir 481 sellardifq edeensdvll fqlpttcvsm apiqlkidll sgqfyfrnpt pllsnyaski 541 nraegpeela rilqqlkldk iihvlttmfe ntgwscsrii kidkpirtqv ntggesvvkk 601 ednkyaiagn sttnsdvsll lqrdlfirlp hwplnwylil siissktscv vekrigkivs 661 qrgkwnlkyl dnsnvmtvkl esityqkimi lqrtilnrii nhmlidslnq leirnkicss 721 emineqklpq yiiqgsntnd nisiitlele sflegskaln silessmflr idysnsqirl 781 yakfkrntmm iqcqidklyi hfvqeeplaf yleesftnlg iivqyltkfr qklmqlvvlt 841 dvverlhknf esenfkiial qpneisfkyl snndeddkdc tikistndds iknltvqlsp 901 snpqhiiqpf ldnskmdyhf ifsylqftss lfkalkviln erggkfhesg sqystmvnig 961 lhnlneyqiv yynpqagtki ticielktvl hngrdkiqfh ihfadvahit tkspaypmmh 1021 qvrnqvfmld tkrlgtpesv kpanashair lgngvacdps eiepilmeih nilkvdsnss 1081 ss // LOCUS NP_013173 693 aa linear PLN 30-JUN-2025 DEFINITION Lam6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013173 VERSION NP_013173.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181959.1 REFERENCE 1 (residues 1 to 693) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 693) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 693) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 693) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09389. Method: conceptual translation. FEATURES Location/Qualifiers source 1..693 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..693 /product="Lam6p" /calculated_mol_wt="78081" Region 175..265 /region_name="PH-GRAM_GRAMDC" /note="GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; cd13220" /db_xref="CDD:275406" Region 406..556 /region_name="VASt" /note="VAD1 Analog of StAR-related lipid transfer domain; pfam16016" /db_xref="CDD:464975" CDS 1..693 /gene="LAM6" /locus_tag="YLR072W" /gene_synonym="LTC1" /coded_by="NM_001181959.1:1..2082" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032366 intracellular sterol transport [PMID:25987606]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:26119743|PMID:26001273|PMID:25987606]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:26001273|PMID:25987606|PMID:26119743]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:25987606]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:26119743]" /note="Sterol transporter that transfers sterols between membranes; may regulate and coordinate formation of contact sites between organelles; localizes to ER-mitochondrial contact sites in a Tom70p- and Tom71p-dependent manner; mitochondrial localization requires GRAM domain; also localizes to ER-vacuole contact sites, in a Vac8p-dependent manner; has GRAM and StART-like (VASt) domains; one of six StART-like domain-containing proteins in yeast; conserved across eukaryotes" /db_xref="GeneID:850761" /db_xref="SGD:S000004062" ORIGIN 1 mwgdsmrelg damdnelnav kpvveeggmd garkfikgks fqksstehml ispgrdgsvp 61 lnglksspad phlsdvnsil dnhrgggeta ltsvnniima tstngdsdgv dgdakrpsis 121 ncssrssffd tvlstfslks nsqdtvtnev knievqfase eankkfrqmf kplapntrli 181 tdyfcyfhre fpyqgriyls nthlcfnstv lnwmaklqip lneikyldkv ttnssaisve 241 tvtnrytfsg fiardevfql itrvwskenl tnindvlevd ervskkkgis stpssifnnv 301 stnayndfis tttteptsra symsendmli eeairsvddy mgtpraspss ssssssssss 361 lgssttyycr pvyrlkpnap fqyegpfhvq etmdfpykpe anneyvller qfsvppgllf 421 immfnednpv felsflktqd ssnishigtf ekvnkdgqhy refqytkqlh fpvgpkstnc 481 evaeillhcd weryinvlsi trtpnvpsgt sfstrtrymf rwddqgqgci lkisfwvdwn 541 asswikpmve snckngqisa tkdlvklvee fvekyvelsk ekadtlkplp svtsfgsprk 601 vaapeltmvq peskpeaeae iseigsdrwr fnwvniiilv llvlnllylm klnkkmdklt 661 nlmthkdevv ahatlldipa kvqwsrprrg dvl // LOCUS NP_013174 200 aa linear PLN 30-JUN-2025 DEFINITION Rfu1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013174 VERSION NP_013174.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181960.1 REFERENCE 1 (residues 1 to 200) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 200) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 200) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 200) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09390. Method: conceptual translation. FEATURES Location/Qualifiers source 1..200 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..200 /product="Rfu1p" /calculated_mol_wt="22719" CDS 1..200 /gene="RFU1" /locus_tag="YLR073C" /coded_by="NM_001181960.1:1..603" /experiment="EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:19410548]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095|PMID:24962567]" /experiment="EXISTENCE:mutant phenotype:GO:0010992 ubiquitin recycling [PMID:19410548]" /note="Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes" /db_xref="GeneID:850762" /db_xref="SGD:S000004063" ORIGIN 1 mksskqlvqd akdyrfnpai plriylktci gilekaqcaf qandlslsfi yyfryvdllt 61 nklsrhpell rmdassssss syihkreylq liklevpavc kiieslrtqi dsqysklqts 121 lanniakpni nanttpvqve qqplpkksfd eysfnqsisf fqkisnaqln tgassqsqat 181 ardeayrlny pelprltfst // LOCUS NP_013175 166 aa linear PLN 30-JUN-2025 DEFINITION Bud20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013175 VERSION NP_013175.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181961.1 REFERENCE 1 (residues 1 to 166) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 166) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 166) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 166) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 166) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09391. Method: conceptual translation. FEATURES Location/Qualifiers source 1..166 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..166 /product="Bud20p" /calculated_mol_wt="18386" Region 1..133 /region_name="UFD2" /note="U1-like Zn-finger-containing protein [General function prediction only]; COG5112" /db_xref="CDD:227443" CDS 1..166 /gene="BUD20" /locus_tag="YLR074C" /coded_by="NM_001181961.1:1..501" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23212245|PMID:11452010]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23045392|PMID:23212245]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23045392|PMID:23212245]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:23045392]" /experiment="EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:23212245|PMID:23045392]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:23212245|PMID:23045392]" /note="C2H2-type zinc finger protein required for ribosome assembly; shuttling factor which associates with pre-60S particles in the nucleus, accompanying them to the cytoplasm; cytoplasmic dissociation of Bud20p requires Drg1p; N-terminus harbors a nuclear localization signal (NLS) and a nuclear export signal (NES); cytoplasmic Bud20p is reimported by Kap123-dependent pathway; involved in bud-site selection; diploid mutants display a random budding pattern; similar to human ZNF593" /db_xref="GeneID:850763" /db_xref="SGD:S000004064" ORIGIN 1 mgrysvkryk tkrrtrdldl iyndlstkes vqkllnqpld etkpglgqhy cihcakymet 61 aialkthlkg kvhkrrvkel rgvpytqevs daaagynlnk flnrvqeitq svgpekesne 121 allkehldst lanvkttept lpwaaadaea ntaavteaes tasast // LOCUS NP_013176 221 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL16 RPL10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013176 VERSION NP_013176.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181962.1 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09392. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..221 /product="60S ribosomal protein uL16 RPL10" /calculated_mol_wt="25230" Region 1..206 /region_name="PTZ00173" /note="60S ribosomal protein L10; Provisional" /db_xref="CDD:185498" Site order(43..44,47,63..64,67,70,74,77,88..90,92,94,98..99, 115..119,133,153..154,157..158) /site_type="other" /note="23S rRNA interface [nucleotide binding]" /db_xref="CDD:238714" Site 56..57 /site_type="other" /note="5S rRNA interface [nucleotide binding]" /db_xref="CDD:238714" Site order(68..70,73..74) /site_type="other" /note="putative antibiotic binding site [chemical binding]" /db_xref="CDD:238714" Site order(77,85..86,88,139) /site_type="other" /note="L25 interface [polypeptide binding]" /db_xref="CDD:238714" Site order(113..114,117..118) /site_type="other" /note="L27 interface [polypeptide binding]" /db_xref="CDD:238714" CDS 1..221 /gene="RPL10" /locus_tag="YLR075W" /gene_synonym="GRC5; QSR1" /coded_by="NM_001181962.1:1..666" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:18824477|PMID:9580698]" /experiment="EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:18824477]" /note="Ribosomal 60S subunit protein L10; homologous to mammalian ribosomal protein L10 and bacterial L16; responsible for joining the 40S and 60S subunits; regulates translation initiation; similar to members of the QM gene family; protein abundance increases under DNA replication stress; mutations in human homolog implicated in T-cell acute lymphoblastic leukemia and also autism spectrum disorders (ASD); human RPL10 can complement yeast null mutant" /db_xref="GeneID:850764" /db_xref="SGD:S000004065" ORIGIN 1 marrparcyr yqknkpypks rynravpdsk iriydlgkkk atvdefplcv hlvsneleql 61 ssealeaari cankymttvs grdafhlrvr vhpfhvlrin kmlscagadr lqqgmrgawg 121 kphglaarvd igqiifsvrt kdsnkdvvve glrrarykfp gqqkiilskk wgftnldrpe 181 ylkkreagev kddgafvkfl skkgslenni refpeyfaaq a // LOCUS NP_013178 583 aa linear PLN 30-JUN-2025 DEFINITION Fmp25p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013178 VERSION NP_013178.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181964.1 REFERENCE 1 (residues 1 to 583) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 583) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 583) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 583) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09393. Method: conceptual translation. FEATURES Location/Qualifiers source 1..583 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..583 /product="Fmp25p" /calculated_mol_wt="66559" Region <293..532 /region_name="ATS1" /note="Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5184" /db_xref="CDD:444065" CDS 1..583 /gene="FMP25" /locus_tag="YLR077W" /gene_synonym="BCA1" /coded_by="NM_001181964.1:1..1752" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:21168530]" /experiment="EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:21168530]" /note="Protein required for assembly of respiratory complex III; mitochondrial inner membrane protein; required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria" /db_xref="GeneID:850766" /db_xref="SGD:S000004067" ORIGIN 1 msfrlftrts qrlprlnwvs pirryakqpq ydeaelfaen inhgaykakk rpsdehfqwp 61 ekspdqitke selqwermak lsavgqgili lvvvgglgta ylrwpelksw wlikmnggri 121 natqeqsgqd sleklirqka knllreipqv pafqlgidhp gvyiwgrchs kdslfpvrvp 181 nldgrkfrdi llapsddfnt nfaidekgdl iswddlgqtk tilpdqdlts mkysshflya 241 lnkkgeilvi pirtpdlias qvssrrskll pwktklrydw klqtnqifng kegekrvvqf 301 dagshhlvll snlgkaycca tgndqkqaqv skgqfgiptf sqfdefppnn qlfeiellnk 361 fkhegedvvr kreikkiacg syhtlaidkt geiyafgwnr fgqlalpisy nleyvsfprs 421 vthafkphfp gmtnwkcvdi hcddetsfvt irkpgstsdh hyfafgnglf gelgnntfkn 481 sqcdpikiks ddkkltnwsc gshcvftete qeneviawgn ndhgqlgigk ktmkcakpmn 541 ipevlkpgqd ttdldsiyns klhlkkeqrv vtngnkscly wrv // LOCUS NP_013179 244 aa linear PLN 30-JUN-2025 DEFINITION Bos1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013179 VERSION NP_013179.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181965.1 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09394. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..244 /product="Bos1p" /calculated_mol_wt="27369" Region 152..217 /region_name="SNARE_GS27" /note="SNARE motif of GS27; cd15863" /db_xref="CDD:277216" Site order(157..159,161..166,168..169,172..173,175..180, 182..183,185..187,189..194,196..197,199..201,203..204, 206..208,210..211,213) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277216" Site 186 /site_type="other" /note="zero layer" /db_xref="CDD:277216" CDS 1..244 /gene="BOS1" /locus_tag="YLR078C" /gene_synonym="SEC32" /coded_by="NM_001181965.1:1..735" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11001058]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:1396561]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0012507 ER to Golgi transport vesicle membrane [PMID:8500167]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:1396561]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11001058]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8500167]" /experiment="EXISTENCE:mutant phenotype:GO:0048280 vesicle fusion with Golgi apparatus [PMID:8500167]" /note="v-SNARE (vesicle specific SNAP receptor); localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi; required for efficient nuclear fusion during mating" /db_xref="GeneID:850767" /db_xref="SGD:S000004068" ORIGIN 1 mnalynhavk qknqlqqela rfeknsvtap islqgsisat lvslektvkq yaehlnryke 61 dtnaeeidpk fanrlatltq dlhdftakfk dlkqsynenn srtqlfgsga shvmdsdnpf 121 stsetimnkr nvggasangk egssnggglp lyqglqkeqs vfergnaqld yilemgqqsf 181 eniveqnkil skvqdrmsng lrtlgvseqt itsinkrvfk dklvfwiali lliigiyyvl 241 kwlr // LOCUS NP_013180 284 aa linear PLN 30-JUN-2025 DEFINITION cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013180 VERSION NP_013180.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181966.1 REFERENCE 1 (residues 1 to 284) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 284) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 284) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 284) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09395. Method: conceptual translation. FEATURES Location/Qualifiers source 1..284 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..284 /product="cyclin-dependent protein serine/threonine kinase inhibiting protein SIC1" /calculated_mol_wt="32092" CDS 1..284 /gene="SIC1" /locus_tag="YLR079W" /gene_synonym="BYC1; SDB25" /coded_by="NM_001181966.1:1..855" /experiment="EXISTENCE:direct assay:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:7954792|PMID:8421781]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16294029|PMID:11792824|PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11792824]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:7954792]" /experiment="EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:20417603]" /note="Cyclin-dependent kinase inhibitor (CKI); inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylated by Clb5/6-Cdk1 and Cln1/2-Cdk1 kinase which regulate timing of Sic1p degradation; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1" /db_xref="GeneID:850768" /db_xref="SGD:S000004069" ORIGIN 1 mtpstpprsr gtrylaqpsg ntsssalmqg qktpqkpsqn lvpvtpsttk sfknapllap 61 pnsnmgmtsp fngltspqrs pfpkssvkrt lfqfeshdng tvreeqeplg rvnrilfptq 121 qnvdidaaee eeegevllpp srptsarqlh lslerdefdq thrkkiikdv pgtpsdkvit 181 felaknwnnn spkndarsqe sedeediiin pvrvgknpfa sdelvtqeir nerkramlre 241 npdiedvity vnkkgevvek rrltdeekrr fkpkalfqsr dqeh // LOCUS NP_013181 444 aa linear PLN 30-JUN-2025 DEFINITION Emp46p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013181 VERSION NP_013181.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181967.1 REFERENCE 1 (residues 1 to 444) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 444) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 444) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 444) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09396. Method: conceptual translation. FEATURES Location/Qualifiers source 1..444 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..444 /product="Emp46p" /calculated_mol_wt="50816" Region 56..270 /region_name="lectin_EMP46_EMP47" /note="EMP46 and EMP47 type 1 transmembrane proteins, N-terminal lectin domain; cd06903" /db_xref="CDD:173891" Site order(132,253) /site_type="other" /note="carbohydrate binding site [chemical binding]" /db_xref="CDD:173891" Site order(177,187..188,190) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:173891" CDS 1..444 /gene="EMP46" /locus_tag="YLR080W" /coded_by="NM_001181967.1:1..1335" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12134087]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030246 carbohydrate binding [PMID:16439369]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:12134087]" /experiment="EXISTENCE:physical interaction:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:12857885]" /note="Integral membrane component of ER-derived COPII-coated vesicles; functions in ER to Golgi transport; EMP46 has a paralog, EMP47, that arose from the whole genome duplication" /db_xref="GeneID:850769" /db_xref="SGD:S000004070" ORIGIN 1 mttrktassl qllgkitgtk agtkqkkmnf ingliwlymc vwmvhgkvtq kdelkwnkgy 61 slpnllevtd qqkelsqwtl gdkvkleegr fvltpgkntk gslwlkpeys ikdamtiewt 121 frsfgfrgst kgglafwlkq gnegdstelf ggsskkfngl millrlddkl gesvtaylnd 181 gtkdldiess pyfasclfqy qdsmvpstlr ltynpldnhl lklqmdnrvc fqtrkvkfmg 241 sspfrigtsa indaskesfe ilkmklydgv iedslipnvn pmgqprvvtk vinsqtgees 301 frekmpfsdk eesitsnelf ekmnklegki mandidpllr kmnkivener eliqrlrpll 361 dlkktaisdd sfqdflsmna nldrlikeqe kirqdaklyg kqtkghdeif skisvwlall 421 ifimitlayy mfrinqdikk vkll // LOCUS NP_013182 574 aa linear PLN 30-JUN-2025 DEFINITION galactose permease GAL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013182 VERSION NP_013182.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181968.1 REFERENCE 1 (residues 1 to 574) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 574) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 574) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 574) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09397. Method: conceptual translation. FEATURES Location/Qualifiers source 1..574 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..574 /product="galactose permease GAL2" /calculated_mol_wt="63495" Region 74..534 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(85,89,215,218..219,222,341..342,346..347,350..351, 376,446..447,450..451,455,478..479,482) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..574 /gene="GAL2" /locus_tag="YLR081W" /coded_by="NM_001181968.1:1..1725" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9045811]" /experiment="EXISTENCE:direct assay:GO:0055056 D-glucose transmembrane transporter activity [PMID:12702270]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005354 galactose transmembrane transporter activity [PMID:3082856]" /experiment="EXISTENCE:mutant phenotype:GO:0006012 galactose metabolic process [PMID:3082856]" /experiment="EXISTENCE:mutant phenotype:GO:0015757 galactose transmembrane transport [PMID:3082856]" /note="Galactose permease; required for utilization of galactose; also able to transport glucose" /db_xref="GeneID:850770" /db_xref="SGD:S000004071" ORIGIN 1 maveennmpv vsqqpqaged visslskdsh lsaqsqkysn delkagesgs egsqsvpiei 61 pkkpmseyvt vsllclcvaf ggfmfgwdtg tisgfvvqtd flrrfgmkhk dgthylsnvr 121 tglivaifni gcafggiils kggdmygrkk glsivvsvyi vgiiiqiasi nkwyqyfigr 181 iisglgvggi avlcpmlise iapkhlrgtl vscyqlmita giflgyctny gtksysnsvq 241 wrvplglcfa wslfmigalt lvpesprylc evnkvedakr siaksnkvsp edpavqaeld 301 limagieaek lagnaswgel fstktkvfqr llmgvfvqmf qqltgnnyff yygtvifksv 361 glddsfetsi vigvvnfast ffslwtvenl ghrkclllga atmmacmviy asvgvtrlyp 421 hgksqpsskg agncmivftc fyifcyattw apvawvitae sfplrvkskc malasasnwv 481 wgfliafftp fitsainfyy gyvfmgclva mffyvfffvp etkglsleei qelweegvlp 541 wksegwipss rrgnnydled lqhddkpwyk amle // LOCUS NP_013183 392 aa linear PLN 30-JUN-2025 DEFINITION Srl2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013183 VERSION NP_013183.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181969.1 REFERENCE 1 (residues 1 to 392) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 392) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 392) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 392) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09398. Method: conceptual translation. FEATURES Location/Qualifiers source 1..392 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..392 /product="Srl2p" /calculated_mol_wt="45009" CDS 1..392 /gene="SRL2" /locus_tag="YLR082C" /coded_by="NM_001181969.1:1..1179" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006139 nucleobase-containing compound metabolic process [PMID:9744871]" /note="hypothetical protein; overexpression suppresses the lethality caused by a rad53 null mutation" /db_xref="GeneID:850771" /db_xref="SGD:S000004072" ORIGIN 1 msnfknftln sfedyygkps etpkmeeekl evtnvnasss kkvhkskkst skydqknvfr 61 nsmtgiaqil ptkpvkiieq nidfanpksf dllqsthtic fnkrinttnt klnvethtss 121 didndilhvg aptdlggnsn deaetrqlrk frwsnnkeks lcekltviyw alllhttkra 181 skrrpilchq miaeffnrvy keksrvpits ryirdnlvaw vtqgkelhek gwvgdaktgd 241 lqeqfniatv klyesaedgr lsigkdkpfr eentgsdslv raeedstavt nenghissek 301 nlkkdrresi rnqiltldln dedffqnvmk vlsaidepel rqyvivisel vsmemddgkt 361 vreklrdvel ninrlqvdik eikemlvtli nk // LOCUS NP_013184 667 aa linear PLN 30-JUN-2025 DEFINITION Emp70p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013184 VERSION NP_013184.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181970.1 REFERENCE 1 (residues 1 to 667) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 667) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 667) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 667) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 667) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09399. Method: conceptual translation. FEATURES Location/Qualifiers source 1..667 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..667 /product="Emp70p" /calculated_mol_wt="75832" Region 72..624 /region_name="EMP70" /note="Endomembrane protein 70; pfam02990" /db_xref="CDD:460774" CDS 1..667 /gene="EMP70" /locus_tag="YLR083C" /gene_synonym="TMN1" /coded_by="NM_001181970.1:1..2004" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20681974]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:8314797]" /experiment="EXISTENCE:genetic interaction:GO:0006878 intracellular copper ion homeostasis [PMID:20681974]" /experiment="EXISTENCE:genetic interaction:GO:0007034 vacuolar transport [PMID:20526336]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:18178563]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:18178563]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:20681974]" /experiment="EXISTENCE:mutant phenotype:GO:0016197 endosomal transport [PMID:20526336]" /note="Protein with a role in cellular adhesion and filamentous growth; also endosome-to-vacuole sorting; similar to Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; EMP70 has a paralog, TMN2, that arose from the whole genome duplication" /db_xref="GeneID:850772" /db_xref="SGD:S000004073" ORIGIN 1 miykmahvql lllyffvstv kafylpgvap ttyrendnip llvnhltpsm nyqhkdedgn 61 nvsgdkenfl ysydyyynrf hfcqpekvek qpeslgsvif gdriynspfq lnmlqekece 121 slcktvipgd dakfinklik ngffqnwlid glpaarevyd grtktsfyga gfnlgfvqvt 181 qgtdieatpk gaettdkdve letrndrnmv ktyelpyfan hfdimieyhd rgegnyrvvg 241 vivepvsikr sspgtcettg splmldegnd nevyftysvk fnesatswat rwdkylhvyd 301 psiqwfslin fslvvvllss vvihsllral ksdfarynel nldddfqeds gwklnhgdvf 361 rspsqsltls ilvgsgvqlf lmvtcsiffa algflspssr gslatvmfil yalfgfvgsy 421 tsmgiykffn gpywkanlil tpllvpgail liiialnffl mfvhssgvip astlffmvfl 481 wflfsiplsf agsliarkrc hwdehptktn qiarqipfqp wylktipatl iagifpfgsi 541 avelyfiyts lwfnkifymf gflffsflll tltsslvtil ityhslclen wkwqwrgfii 601 ggagcalyvf ihsilftkfk lggfttivly vgyssvisll cclvtgsigf issmlfvrki 661 yssikvd // LOCUS NP_013185 1220 aa linear PLN 30-JUN-2025 DEFINITION Rax2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013185 VERSION NP_013185.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181971.1 REFERENCE 1 (residues 1 to 1220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1220) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09400. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1220 /product="Rax2p" /calculated_mol_wt="133828" Region 976..1111 /region_name="Rax2" /note="Cortical protein marker for cell polarity; pfam12768" /db_xref="CDD:463693" CDS 1..1220 /gene="RAX2" /locus_tag="YLR084C" /coded_by="NM_001181971.1:1..3663" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:11110666|PMID:25416945|PMID:15356260]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:11110666|PMID:15356260]" /experiment="EXISTENCE:genetic interaction:GO:0007121 bipolar cellular bud site selection [PMID:11110666]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:29074565]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:11110666]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:25416945]" /note="Protein required for the maintenance of bud site selection; localizes; localization to the bud neck and previous sites of cell division (bud scars; cytokinesis remnants (CRMs)) is interdependent with Rax2p; required with Rax1p to anchor both Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established preventing repolarization of cells at previous division sites; RAX2 mRNA stability is regulated by Mpt5p; predicted type I membrane-spanning protein; N-glycosylated" /db_xref="GeneID:850773" /db_xref="SGD:S000004074" ORIGIN 1 mfvhrlwtla fpflveiska sqleniksll diednvlpnl nisqnnsnav qilggvdals 61 fyeytgqqnf tkeigpetss hglvyysnnt yiqledasdd tridkitpfg vdsfilsgsg 121 tinnisvgnq ilynlstlsm tpifnqslga vqavladnss iyfggnfsyn ngsmtgysal 181 iwdsisnttq llpfggfgen ssvnsivkln ndnilfagqf ytlddpsali sssnngtnst 241 sslnattlel gqriplryas wdsqgsttfa sdslvcpntn edawlypdts gslvcnlpye 301 vsptkirlyn sqrsdseisv fqiltdpsss imnltyldpl sgelkncgef cplysratll 361 sasqnvsssm dmitfidnnk tdvkwtsdfq dfafvnelpv sslkfvalns yggsvglsgl 421 elyqdtfsty andslneygc saltndssss tlssndwyng ltgesyiaak yvpdqnepip 481 rvkfypniih pghytinmyt pgclqdntcs argivnvtmw nqqnntimkt yliyqnndnl 541 kydqiysgyl dfspeivley vsgiyttnta tvvvadqvnv itvsldafnt lsdssnakke 601 tllngilqyq ksnftstrln etkvgnttln lfpvknypkn sslyadiydn klviggvsnr 661 isivdlnddf evtssknqti qgdvhgitkt nqgllifgdi lssnnqsavf lfngsfenvf 721 nqsrtvnsal nislanndfi vldndyvvna ssnalirnss sfslslwaag nngdgdvlfs 781 gavshmqygn lngsvrflne neieplnleg givpylgayl nesatayaye vdslnkiyfs 841 nevypswnws sgitqmlyad nqtllavsag ssttaelsif dlrnltmian etlgsnarin 901 alvnfekncs mlvggdfqmt epnctglcly nyesktwstf lnntifgeit qlsftnssel 961 iisglfetke yqsirlgsfn ltnstmipll sgsegklnsf tvtedsivaw ndtslfiyrn 1021 qewnitslpg nassissvsa iytdiesntl nkrginnvnn gsilllngnf nisqygylqs 1081 llfdfqkwtp yfisettnts nynpiifinr dvstefnsqs planvnitvt spqstssqpp 1141 sssassesks kskkkkigrg fvvliglala lgtvsvlgia gvilayvfkd pegdykpikp 1201 ridenemldt vppeklmkfv // LOCUS NP_013186 438 aa linear PLN 30-JUN-2025 DEFINITION Arp6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013186 VERSION NP_013186.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181972.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09401. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..438 /product="Arp6p" /calculated_mol_wt="49913" Region 6..423 /region_name="ASKHA_NBD_Arp6" /note="nucleotide-binding domain (NBD) of actin-related protein6 (Arp6) and similar proteins; cd10210" /db_xref="CDD:466816" CDS 1..438 /gene="ARP6" /locus_tag="YLR085C" /coded_by="NM_001181972.1:1..1317" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14690608|PMID:14645854|PMID:16299513]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11011149]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:14690608]" /experiment="EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:16299513]" /note="Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A" /db_xref="GeneID:850774" /db_xref="SGD:S000004075" ORIGIN 1 metppividn gsyeikfgps tnkkpfraln alakdkfgts ylsnhiknik dissitfrrp 61 helgqltlwe lesciwdycl fnpsefdgfd lkegkghhlv asescmtlpe lskhadqvif 121 eeyefdslfk spvavfvpft ksykgemrti sgkdedidiv rgnsdstnst ssesknaqds 181 gsdyhdfqlv idsgfnctwi ipvlkgipyy kavkkldigg rfltgllket lsfrhynmmd 241 etilvnnike qclfvspvsy fdsfktkdkh aleyvlpdfq tsflgyvrnp rkenvplped 301 aqiitltdel ftipetffhp eisqitkpgi veaileslsm lpeivrplmv gnivctggnf 361 nlpnfaqrla aelqrqlptd wtchvsvpeg dcalfgwevm sqfaktdsyr karvtreeyy 421 ehgpdwctkh rfgyqnwi // LOCUS NP_013187 1418 aa linear PLN 30-JUN-2025 DEFINITION condensin subunit SMC4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013187 VERSION NP_013187.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181973.1 REFERENCE 1 (residues 1 to 1418) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1418) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1418) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1418) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09402. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1418 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1418 /product="condensin subunit SMC4" /calculated_mol_wt="162059" Region 155..1406 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; pfam02463" /db_xref="CDD:426784" CDS 1..1418 /gene="SMC4" /locus_tag="YLR086W" /coded_by="NM_001181973.1:1..4257" /experiment="EXISTENCE:direct assay:GO:0000796 condensin complex [PMID:10811823]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11864994]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12719426]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:10811823]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:10811823]" /experiment="EXISTENCE:mutant phenotype:GO:0070058 tRNA gene clustering [PMID:18708579]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:10811823]" /note="Subunit of the condensin complex; condensin reorganizes chromosomes during both mitosis and meiosis; forms a subcomplex with Smc2p that has ATP-hydrolyzing and DNA-binding activity, but other condensin subunits are required for chromatin binding; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate" /db_xref="GeneID:850775" /db_xref="SGD:S000004076" ORIGIN 1 msdsplskrq krksaqepel sldqgdaeed sqvenrvnls entpepdlpa leasysksyt 61 prklvlssge nryafsqptn stttslhvpn lqppktssrg rdhksysqsp prspgrsptr 121 rlellqlspv knsrvelqki ydrhqssskq qsrlfinelv lenfksyagk qvvgpfhtsf 181 savvgpngsg ksnvidsmlf vfgfrankmr qdrlsdlihk seafpslqsc svavhfqyvi 241 dessgtsrid eekpgliitr kafknnssky yinekessyt evtkllkneg idldhkrfli 301 lqgeveniaq mkpkaekesd dglleyledi igtanykpli eermgqienl nevclekenr 361 feivdrekns lesgketale flekekqltl lrsklfqfkl lqsnsklast lekisssnkd 421 ledekmkfqe slkkvdeika qrkeikdris scsskektlv lerrelegtr vsleertknl 481 vskmekaekt lkstkhsise aenmleelrg qqteheteik dltqlleker silddiklsl 541 kdktknisae iirhekelep wdlqlqekes qiqlaesels lleetqaklk knvetleeki 601 lakkthkqel qdlildlkkk lnslkdersq geknftsahl klkemqkvln ahrqramear 661 sslskaqnks kvltalsrlq ksgringfhg rlgdlgvidd sfdvaistac prlddvvvdt 721 vecaqhcidy lrknklgyar filldrlrqf nlqpistpen vprlfdlvkp knpkfsnafy 781 svlrdtlvaq nlkqannvay gkkrfrvvtv dgklidisgt msgggnhvak glmklgtnqs 841 dkvddytpee vdkierelse rennfrvasd tvhemeeelk klrdhepdle sqiskaemea 901 dslaseltla eqqvkeaema yvkavsdkaq lnvvmknler lrgeyndlqs etktkkekik 961 glqdeimkig giklqmqnsk vesvcqkldi lvaklkkvks askksggdvv kfqkllqnse 1021 rdvelssdel kvieeqlkht klalaendtn mnetlnlkve lkeqseqlke qmedmeesin 1081 efksieiemk nkleklnsll tyikseitqq ekglnelsir dvthtlgmld dnkmdsvked 1141 vknnqeldqe yrscetqdes eikdaetscd nyhpmnidet sdevsrgipr lsedelreld 1201 velieskine lsyyveetnv digvleeyar rlaefkrrkl dlnnavqkrd evkeqlgilk 1261 kkrfdefmag fniismtlke myqmitmggn aelelvdsld pfsegvtfsv mppkkswrni 1321 tnlsggektl sslalvfalh kykptplyvm deidaaldfr nvsivanyik ertknaqfiv 1381 islrnnmfel aqqlvgvykr dnrtksttik nidilnrt // LOCUS NP_013188 2958 aa linear PLN 30-JUN-2025 DEFINITION Csf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013188 VERSION NP_013188.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181974.1 REFERENCE 1 (residues 1 to 2958) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2958) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 2958) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2958) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 2958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 2958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09403. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2958 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..2958 /product="Csf1p" /calculated_mol_wt="338128" Region 39..1056 /region_name="Kiaa1109_N" /note="Kiaa1109 N-terminal region; pfam20413" /db_xref="CDD:466562" CDS 1..2958 /gene="CSF1" /locus_tag="YLR087C" /coded_by="NM_001181974.1:1..8877" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0006113 fermentation [PMID:10781556]" /experiment="EXISTENCE:mutant phenotype:GO:0009631 cold acclimation [PMID:35188676]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:19433630]" /experiment="EXISTENCE:mutant phenotype:GO:0055091 phospholipid homeostasis [PMID:35188676]" /note="Protein with structural similarity to lipid transport protein Vps13p; localizes to multiple membrane contact sites between organelles; role in phospholipid homeostasis and lipidomic adaptation to cold; required for fermentation at low temperature; plays a role in phosphatidylethanolamine metabolism and secretory protein maturation; non-tagged protein is detected in highly purified mitochondria in HTP studies" /db_xref="GeneID:850776" /db_xref="SGD:S000004077" ORIGIN 1 meaisqlrgv plthqkdfsw vflvdwiltv vvcltmifym griyaylvsf ilewllwkra 61 kikinvetlr vsllggrihf knlsvihkdy tisvlegslt wkywllncrk aeliennkss 121 sgkkaklpck isveceglei fiynrtvayd nvinllskde rdkfekylne hsfpepfsdg 181 ssadkldedl sesayttnsd asivndrdyq etdigkhpkl lmflpielkf srgslllgnk 241 ftpsvmilsy esgkgiidvl ppkerldlyr nktqmefknf eisikqnigy ddaiglkfki 301 drgkvsklwk tfvrvfqivt kpvvpkktkk sagtsddnfy hkwkglslyk asagdakasd 361 lddvefdltn heyakftsil kcpkvtiayd vdvpgvvphg ahptipdidg pdvgnngapp 421 dfaldvqihg gsicygpwaq rqvshlqrvl spvvsrtakp ikklppgsrr iytlfrmnis 481 imedttwrip tresskdpef lkhyketnee yrpfgwmdlr fckdtyanfn isvcptvqgf 541 qnnfhvhfle teirssvnhd illkskvfdi dgdigyplgw nskaiwiinm kseqleafll 601 rehitlvadt lsdfsagdpt pyelfrpfvy kvnwemegys iylnvndhni vnnpldfnen 661 cylslhgdkl sidvtvpres ilgtytdmsy eistpmfrmm lntppwntln efmkhkevgr 721 aydftikgsy llyseldidn vdtlviecns kstvlhcygf vmryltnvkm nyfgeffnfv 781 tseeytgvlg arevgdvttk ssvadlastv dsgyqnsslk nesedkgpmk rsdlkrttne 841 tdiwftfsvw dgalilpeti ysfdpcialh faelvvdfrs cnyymdimav lngtsikrhv 901 skqinevfdf irrnngadeq ehgllsdlti hghrmyglpp teptyfcqwd inlgdlcids 961 diefikgffn sfykigfgyn dlenillydt etindmtslt vhvekirigl kdpvmksqsv 1021 isaesilftl idfenekysq ridvkipklt islncvmgdg vdtsflkfet klrftnfeqy 1081 kdidkkrseq rryitihdsp yhrcpfllpl fyqdsdtyqn lygaiapsss iptlplptlp 1141 dtidyiiedi vgeyatllet tnpfknifae tpstmepsra sfseddndee adpssfkpva 1201 ftedrnherd nyvvdvsyil ldvdpllfif akslleqlys enmvqvlddi eigivkrlsn 1261 lqegitsisn idihiaylnl iwqetgeegf elyldridyq mseksleknr tnkllevaal 1321 akvktvrvtv nqkknpdlse drppalslgi egfevwsste drqvnslnlt ssditidesq 1381 mewlfeycsd qgnliqevct sfnsiqntrs nskteliskl taaseyyqis hdpyvitkpa 1441 fimrlskghv renrswkiit rlrhiltylp ddwqsnidev lkekkytsak daknifmsvf 1501 stwrnwefsd varsyiygkl ftaenekhkq nlikkllkct mgsfyltvyg egyevehnfv 1561 vadanlvvdl tppvtslpsn reetieitgr vgsvkgkfsd rllklqdlip liaavgeddk 1621 sdpkkelskq fkmntvllvd kselqlvmdq tklmsrtvgg rvsllwenlk dstsqagslv 1681 ifsqksevwl khtsvilgea qlrdfsvlat teawshkpti linnqcadlh framssteql 1741 vtaiteires lmmikerikf kpkskkksqf vdqkintvls cyfsnvssev mplspfyirh 1801 eakqldiyfn kfgsneills iwdtdffmts hqtkeqylrf sfgdieikgg isregyslin 1861 vdisismikl tfseprrivn sflqdeklas qginllyslk plffssnlpk kekqapsimi 1921 nwtldtsity fgvlvpvast yfvfelhmll lsltntnngm lpeetkvtgq fsienilfli 1981 kerslpigls klldfsikvs tlqrtvdteq sfqvesshfr vclspdsllr lmwgahklld 2041 lshyysrrha pniwntkmft gksdkskemp infrsihils ykfcigwifq ygagsnpglm 2101 lgynrlfsay ekdfgkftvv daffsvangn tsstffsegn ekdkynrsfl pnmqisywfk 2161 rcgelkdwff rfhgealdvn fvpsfmdvie stlqsmrafq elkknildvs eslraendns 2221 yastsvesas sslapfldni rsvnsnfkyd ggvfrvytye dietksepsf eikspvvtin 2281 ctykhdedkv kphkfrtlit vdpthntlya gcapllmefs eslqkmikkh stdekpnftk 2341 pssqnvdykr lldqfdvavk ltsakqqlsl scepkakvqa dvgfesflfs matnefdseq 2401 plefsltleh tkasikhifs revstsfevg fmdltllfth pdvismygtg lvsdlsvffn 2461 vkqlqnlylf ldiwrfssil htrpvqrtvn keiemsslts tnyadagtei pwcftliftn 2521 vsgdvdlgps lgmislrtqr twlatdhyne krqllhaftd gisltsegrl sglfevanas 2581 wlsevkwppe ksknthplvs tslniddiav kaafdyhmfl igtisnihfh lhnekdakgv 2641 lpdllqvsfs sdeiilssta lvvanildiy ntivrmrqdn kisymetlrd snpgesrqpi 2701 lykdilrslk llrtdlsvni ssskvqispi slfdvevlvi ridkvsirse thsgkklktd 2761 lqlqvldvsa alstskeeld eevgasiaid dymhyaskiv ggtiidipkl avhmttlqee 2821 ktnnleylfa csfsdkisvr wnlgpvdfik emwtthvkal avrrsqvani sfgqteeele 2881 esikkeeaas kfnyialeep qievpqirdl gdatppmewf gvnrkkfpkf thqtavipvq 2941 klvylaekqy vkilddth // LOCUS NP_013189 614 aa linear PLN 30-JUN-2025 DEFINITION GPI-anchor transamidase subunit GAA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013189 VERSION NP_013189.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181975.1 REFERENCE 1 (residues 1 to 614) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 614) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 614) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 614) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 614) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09404. Method: conceptual translation. FEATURES Location/Qualifiers source 1..614 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..614 /product="GPI-anchor transamidase subunit GAA1" /calculated_mol_wt="69090" Region 117..595 /region_name="Gaa1" /note="Gaa1-like, GPI transamidase component; pfam04114" /db_xref="CDD:461181" CDS 1..614 /gene="GAA1" /locus_tag="YLR088W" /gene_synonym="END2" /coded_by="NM_001181975.1:1..1845" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042765 GPI-anchor transamidase complex [PMID:11598210]" /experiment="EXISTENCE:mutant phenotype:GO:0016255 attachment of GPI anchor to protein [PMID:7730400|PMID:11598210]" /note="Subunit of the GPI:protein transamidase complex; removes the GPI-anchoring signal and attaches GPI (glycosylphosphatidylinositol) to proteins in the ER; human homolog GPAA1 can complement growth defects of yeast thermosensitive mutant at restrictive temperature" /db_xref="GeneID:850777" /db_xref="SGD:S000004078" ORIGIN 1 malleklhrr ivdmglvpri iallpvisml calfgfisia ilpmdgqyrr tyisenalmp 61 sqaysyfres ewnilrgyrs qikemvnmts mernnlmgsw lqefgtktai yeneqygetl 121 ygvmhaprgd gteamvlavp wfnsddefni ggaalgvsla rffsrwpvws kniivvfsen 181 praalrswve ayhtsldltg gsieaavvld ysstedffey veisydglng elpnldlvni 241 aisitehegm kvslhglpsd qltnnnfwsr lkilclgird walsgvkkph gneafsgwri 301 qsvtlkahgn sghdittfgr ipeamfrsin nllekfhqsf ffylllaprq fvsissylps 361 avalsiafai sslnafinna yanislfsey nlvallvwfv slvisfvvsq afllipssgl 421 lmtismascf lplilsrkih iseplsyrlk nvaflyfslv stsllminfa malligtlaf 481 pmtfvktive sssehevttq ssnpiktepk deielvenhm dttpatpqqq kqklknlvll 541 iltnpfisit lfglffddef hgfdiinklv sawldlkcws wfvlcigwlp cwllilassf 601 esksvvvrsk ekqs // LOCUS NP_013190 592 aa linear PLN 30-JUN-2025 DEFINITION alanine transaminase ALT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013190 VERSION NP_013190.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181976.1 REFERENCE 1 (residues 1 to 592) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 592) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 592) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 592) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09405. Method: conceptual translation. FEATURES Location/Qualifiers source 1..592 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..592 /product="alanine transaminase ALT1" /EC_number="2.6.1.2" /calculated_mol_wt="66291" Region 111..590 /region_name="PTZ00377" /note="alanine aminotransferase; Provisional" /db_xref="CDD:240391" CDS 1..592 /gene="ALT1" /locus_tag="YLR089C" /coded_by="NM_001181976.1:1..1779" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14576278|PMID:11502169]" /experiment="EXISTENCE:direct assay:GO:0030170 pyridoxal phosphate binding [PMID:29867852]" /experiment="EXISTENCE:mutant phenotype:GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity [PMID:19396236]" /experiment="EXISTENCE:mutant phenotype:GO:0006523 alanine biosynthetic process [PMID:19396236]" /experiment="EXISTENCE:mutant phenotype:GO:0006524 alanine catabolic process [PMID:19396236]" /note="Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthesis and catabolism; TOR1-independent role in determining chronological lifespan; expression is induced in the presence of alanine; repression is mediated by Nrg1p; ALT1 has a paralog, ALT2, that arose from the whole genome duplication; Alt2p is catalytically inactive" /db_xref="GeneID:850778" /db_xref="SGD:S000004079" ORIGIN 1 mlslsaknhf tvsnsithvi ksyhirtlts saekmphitt pfstsasstk lkafrkvrpv 61 lqrhssswiv aqnhrrslsg qsslndlrhl nrfphhtlkt snnefypaeq ltledvnenv 121 lkakyavrga ipmraeelka qlekdpqslp fdriinanig npqqlqqkpl tyyrqvlsll 181 qypellnqne qqlvdsklfk ldaikraksl mediggsvga ysssqgvegi rksvaefitk 241 rdegeisype difltagasa avnyllsifc rgpetgvlip ipqyplytat lalnnsqalp 301 yyldensgws tnpeeietvv keaiqneikp tvlvvinpgn ptgavlspes iaqifevaak 361 ygtvviadev yqenifpgtk fhsmkkilrh lqrehpgkfd nvqlaslhst skgvsgecgq 421 rggymeltgf shemrqvilk lasislcpvv tgqalvdlmv rppvegeesf esdqaernsi 481 heklitramt lyetfnsleg iecqkpqgam ylfpkidlpf kavqearhle ltpdefyckk 541 llestgictv pgsgfgqepg tyhlrttfla pglewikkwe sfhkeffdqy rd // LOCUS NP_013191 459 aa linear PLN 30-JUN-2025 DEFINITION Xdj1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013191 VERSION NP_013191.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181977.1 REFERENCE 1 (residues 1 to 459) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 459) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 459) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 459) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09406. Method: conceptual translation. FEATURES Location/Qualifiers source 1..459 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..459 /product="Xdj1p" /calculated_mol_wt="51216" Region 8..412 /region_name="PTZ00037" /note="DnaJ_C chaperone protein; Provisional" /db_xref="CDD:240236" CDS 1..459 /gene="XDJ1" /locus_tag="YLR090W" /coded_by="NM_001181977.1:1..1380" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:23329686]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:23329686]" /note="Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:850779" /db_xref="SGD:S000004080" ORIGIN 1 msgsdrgdrl ydvlgvtrda tvqeiktayr klalkhhpdk yvdqdskevn eikfkeitaa 61 yeilsdpekk shydlygddn gaassggang fgdedfmnff nnffnngshd gnnfpgeyda 121 yeegnstssk dididisltl kdlymgkklk fdlkrqvici kchgsgwkpk rkihvthdve 181 cescagkgsk erlkrfgpgl vasqwvvcek cngkgkytkr pknpknfcpd caglgllskk 241 eiitvnvapg hhfndvitvk gmadeeidkt tcgdlkfhlt ekqenleqkq iflknfddga 301 gedlytsiti slsealtgfe kfltktfddr lltlsvkpgr vvrpgdtiki anegwpildn 361 phgrcgdlyv fvhiefppdn wfneksella iktnlpssss cashatvnte ddsnltnnet 421 isnfriihtd dlpegirpfk peaqdsahqk arssycciq // LOCUS NP_013192 293 aa linear PLN 30-JUN-2025 DEFINITION Gep5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013192 VERSION NP_013192.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181978.1 REFERENCE 1 (residues 1 to 293) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 293) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 293) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 293) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09407. Method: conceptual translation. FEATURES Location/Qualifiers source 1..293 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..293 /product="Gep5p" /calculated_mol_wt="33737" Region 9..249 /region_name="GEP5" /note="Genetic interactor of prohibitin 5; pfam17053" /db_xref="CDD:407225" CDS 1..293 /gene="GEP5" /locus_tag="YLR091W" /gene_synonym="RRG5" /coded_by="NM_001181978.1:1..882" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0099617 matrix side of mitochondrial inner membrane [PMID:30759361]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:19751518]" /experiment="EXISTENCE:mutant phenotype:GO:0097745 mitochondrial tRNA 5'-end processing [PMID:30759361]" /note="hypothetical protein; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine; localizes to the matrix side of the inner mitochondrial membrane" /db_xref="GeneID:850780" /db_xref="SGD:S000004081" ORIGIN 1 masqvnalll pviestplhq itkvaltttl tskqsdykfk eiavpltksl qlyekaqrrq 61 dlraslkale siiyqthfqw nnplprhahl fqkhyhfllt hwpfenhrdl vdsiavnngk 121 lnstssrsvw lkadwitlfn vknpwvqtpp slmrlsgtdl dtftperifl inslgnhykf 181 lianshlsyn hkkypspgvq ipvrnalgev spakqiaqlf arqlshiyks lfienpplsp 241 enelaltavf ydetverrlr rlymracara ytttnadstt eplmfhctrw evd // LOCUS NP_013193 893 aa linear PLN 30-JUN-2025 DEFINITION sulfate permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_013193 VERSION NP_013193.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181979.1 REFERENCE 1 (residues 1 to 893) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 893) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 893) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 893) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09408. Method: conceptual translation. FEATURES Location/Qualifiers source 1..893 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..893 /product="sulfate permease" /calculated_mol_wt="99520" Region 137..544 /region_name="Sulfate_transp" /note="Sulfate permease family; pfam00916" /db_xref="CDD:459995" Region <772..835 /region_name="STAS" /note="Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; cl00604" /db_xref="CDD:445002" CDS 1..893 /gene="SUL2" /locus_tag="YLR092W" /coded_by="NM_001181979.1:1..2682" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:9055073]" /experiment="EXISTENCE:mutant phenotype:GO:0015116 sulfate transmembrane transporter activity [PMID:9055073]" /experiment="EXISTENCE:mutant phenotype:GO:1902358 sulfate transmembrane transport [PMID:9055073]" /note="High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates" /db_xref="GeneID:850781" /db_xref="SGD:S000004082" ORIGIN 1 msregypnfe eveipdfqet nntvpdlddl eleydqyknn enndtfndkd lesnsvakhn 61 avnsskgvkg skidyfnpsd vslydnsvsq feettvslke yydhsirshl tvkgacsylk 121 svfpiinwlp hynfswftad liagitigcv lvpqsmsyaq vatlpaqygl yssfigaysy 181 sffatskdvc igpvavmslq takviadvta kypdgdsait gpviattlal lcgiisaavg 241 flrlgflvel islnavagfm tgsafnilwg qvpalmgyns lvntraatyk vvietlkhlp 301 dtkldavfgl iplfllyvwk wwcgtygprl ndrynsknpr lhkiikwtyf yaqasrngii 361 iivftcigwa itrgkskser pisilgsvps glkevgvfhv ppglmsklgp nlpasiivll 421 lehiaisksf grindykvvp dqeliaigvs nllgtffnay patgsfsrsa lkakcnvrtp 481 lsglfsgscv llalycltga ffyipkatls aviihavsdl lasyqttwnf wkmnpldfic 541 fivtvlitvf asiedgiyfa mcwscamlil kvafpagkfl grvevaevtd ayvrpdsdvv 601 syvsennngi stledggedd kesstkyvtn sskkietnvq tkgfdspsss isqprikyht 661 kwipfdhkyt relnpdvqil pppdgvlvyr lsesytylnc srhyniitee vkkvtrrgql 721 irhrkksdrp wndpgpweap aflknlkfwk krendpesme napstsvdve rddrpllkil 781 cldfsqvaqt datalqslvd lrkainqyad rqvefhfvgi ispwvkrgli srgfgtlnee 841 ysdesivagh tsyhvarvpq geenpekysv ytasgtnlpf fhidipdfak wdi // LOCUS NP_013194 253 aa linear PLN 30-JUN-2025 DEFINITION Nyv1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013194 VERSION NP_013194.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181980.1 REFERENCE 1 (residues 1 to 253) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 253) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 253) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 253) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09409. On Aug 9, 2000 this sequence version replaced NP_013194.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..253 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..253 /product="Nyv1p" /calculated_mol_wt="28833" Region 6..144 /region_name="Nyv1_longin" /note="Vacuolar R-SNARE Nyv1, longin domain; pfam09426" /db_xref="CDD:401399" Region 165..250 /region_name="Synaptobrevin" /note="pfam00957" /db_xref="CDD:395764" CDS 1..253 /gene="NYV1" /locus_tag="YLR093C" /gene_synonym="MAM2" /coded_by="NM_001181980.1:1..762" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:16855025|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:19805279]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9425154]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:17400548|PMID:9685264]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:12730205]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:17400548]" /note="v-SNARE component of vacuolar SNARE complex; involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in vacuolar membrane; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:850782" /db_xref="SGD:S000004083" ORIGIN 1 mkrfnvsyve vikngetiss cfqpfqknen ygtitsaneq itpvifhnli mdmvlpkvvp 61 ikgnkvtkms mnlidgfdcf ystddhdpkt vyvcftlvdm pkilpirils glqeyesnat 121 nellsshvgq ildsfheelv eyrnqtlnss gngqssngng qntisdigda tedqikdviq 181 imndnidkfl erqervsllv dktsqlnsss nkfrrkavni keimwwqkvk nitlltftii 241 lfvsaafmff ylw // LOCUS NP_013195 502 aa linear PLN 30-JUN-2025 DEFINITION Gis3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013195 VERSION NP_013195.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181981.1 REFERENCE 1 (residues 1 to 502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 502) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09410. Method: conceptual translation. FEATURES Location/Qualifiers source 1..502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..502 /product="Gis3p" /calculated_mol_wt="56226" CDS 1..502 /gene="GIS3" /locus_tag="YLR094C" /coded_by="NM_001181981.1:1..1509" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0035556 intracellular signal transduction [PMID:10628841]" /note="hypothetical protein" /db_xref="GeneID:850783" /db_xref="SGD:S000004084" ORIGIN 1 mlldvntnht lmhdahvheh cliksirddg alhswsdssk vfypksfyat atnkknnkla 61 sasmnktats nrtvsdeiyf hstkpqfdgq gsaertrtlt krnsfkrtri lkarddsell 121 nenrsslmtp slssvmsqvr ktnsaktlsg ecpiheghlt qsikrkfsee aqsdcsslss 181 sklhpltddi adavdlqtpa igdevlaepv vpkmkiinin dldlfddwev kdlvdifppv 241 yerrprsssa lslvsassda klrptsvdfq iidkkggkts rrksrskstt enmiyendlv 301 eleqwpsasp spetdgsias sellpnkrir qkslntnflk lysietsckr ksilpevevd 361 dhllkqltys eirsleikke pnvstndikl alitrkklws dmvhetrndl fgdstpwnlh 421 fvattsntep sqgresaseh atadlksslv rvhsdvkpwf nnggtmlkpc gklnlgkvtn 481 ktsaptreiq yvvkgwcdsr fl // LOCUS NP_013196 812 aa linear PLN 30-JUN-2025 DEFINITION Ioc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013196 VERSION NP_013196.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181982.1 REFERENCE 1 (residues 1 to 812) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 812) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 812) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 812) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 812) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 812) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 812) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 812) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 812) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09411. Method: conceptual translation. FEATURES Location/Qualifiers source 1..812 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..812 /product="Ioc2p" /calculated_mol_wt="93315" Region 556..>584 /region_name="PHD_SF" /note="PHD finger superfamily; cl22851" /db_xref="CDD:473978" CDS 1..812 /gene="IOC2" /locus_tag="YLR095C" /coded_by="NM_001181982.1:1..2439" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0036437 Isw1b complex [PMID:12482963]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12482963]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:12482963]" /note="Subunit of the Isw1b complex; exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing; contains a PHD finger motif; other complex members are Isw1p and Ioc4p" /db_xref="GeneID:850784" /db_xref="SGD:S000004085" ORIGIN 1 mrtkrtrgtr nvgasmpaga anadsedwke yvsediiaql nkhqlpysei ldekiadlan 61 hwhfqyvmaw lsnvcesytt ttfntdqygg sstkclwkni kfdegvfvtd vfskidgkds 121 nyyndevdvd egsqnlydri rlqllhqlag nksgqlkdwn vivnhhlqns saysdlvtdl 181 pfleleiarq fdiiysiikl iemknmifkn ylannlhlft fsevildddn sggeemkslf 241 alpnvgvlvk ktihrvkegs ssqvsqtlni piklqnctik esdpdipdsv elihleyshd 301 idaylqsiti dydvittnwg smleywsenk sskaidefit nlipvyaehr lysakllanr 361 ekeraiaelm trrkrssrlv akeeenkkkd lesewfekld ereqfirhrn klvskeikki 421 kdllwnqlwq lydqdyrdek ltrrnelkdr sgsgtpffet slgreednpl neidigvldh 481 gpnfqssiip veppipgtvg plqtgdvpel psdfcitkee ldelanygif tpqqepdnqd 541 svfqcpgepe lapmiitedt etdlfnnrpl iccdhcyrwq hwecqppkii elissttksp 601 qhtlsqrdfg viimgnshgn rrssrrpqst lepstkssrp tdkrkplsec stficawcir 661 dlelelrnif vpelkiirak qrkqqedrer rkkmkeekkr leelakkrel tesvsppvfn 721 nafanmssst tpsiaayekt npainpapnv naahpiitys qqtgsktvpq apqapqtsqa 781 siqpqqqqqq qqqqqplhpk eqnfhfqfpp tn // LOCUS NP_013197 1147 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase KIN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013197 VERSION NP_013197.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181983.1 REFERENCE 1 (residues 1 to 1147) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1147) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1147) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1147) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1147) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09412. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1147 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1147 /product="serine/threonine protein kinase KIN2" /EC_number="2.7.11.1" /calculated_mol_wt="128208" Region 97..377 /region_name="STKc_Kin1_2" /note="Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; cd14077" /db_xref="CDD:270979" Site order(105..109,113,126,128,186,202..205,209,211..212,214, 247..248,250,252..253,255,265..266,269,283..287,289, 319..322) /site_type="active" /db_xref="CDD:270979" Site order(105..108,113,126,128,186,202..205,209,252..253,255, 265..266) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270979" Site order(209,211..212,214,248,250,252,269,283..287,289, 319..322) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270979" Site 265..287 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270979" Region 1104..1147 /region_name="KA1" /note="Kinase associated domain 1; pfam02149" /db_xref="CDD:460465" CDS 1..1147 /gene="KIN2" /locus_tag="YLR096W" /coded_by="NM_001181983.1:1..3444" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8203145]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8020610]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:27096577]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:27096577]" /experiment="EXISTENCE:genetic interaction:GO:0045921 positive regulation of exocytosis [PMID:15563607]" /experiment="EXISTENCE:genetic interaction:GO:1903896 positive regulation of IRE1-mediated unfolded protein response [PMID:25348718]" /experiment="EXISTENCE:physical interaction:GO:0005886 plasma membrane [PMID:15563607]" /experiment="EXISTENCE:physical interaction:GO:0045921 positive regulation of exocytosis [PMID:15563607]" /note="S/T protein kinase; regulates polarized exocytosis and the Ire1p-mediated UPR; regulates HAC1 mRNA translocation, splicing and translation with KIN1 during ER stress; direct phosphorylation of Sec9p (S190) is enhanced by prior substrate priming (S192); localizes to the cytoplasmic face of the PM and sites of polarized growth; may regulate septin and cell wall organization; activation loop phosphorylation (T281) required for full kinase activity; orthologous to MARK/PAR-1, AMPK family members" /db_xref="GeneID:850785" /db_xref="SGD:S000004086" ORIGIN 1 mpnpntadyl vnpnfrtskg gslsptpeaf ndtrvaapat lrmmgkqsgp rndqqqaplm 61 ppadikqgke qaaqrqndas rpngavelrq fhrrslgdwe fletvgagsm gkvklvkhrq 121 tkeicvikiv nraskaylhk qhslpspkne seilerqkrl ekeiardkrt vreaslgqil 181 yhphicrlfe mctmsnhfym lfeyvsggql ldyiiqhgsl kehharkfar giasalqylh 241 annivhrdlk ienimisssg eikiidfgls nifdyrkqlh tfcgslyfaa pellkaqpyt 301 gpevdiwsfg ivlyvlvcgk vpfddenssi lhekikkgkv dypshlsiev islltrmivv 361 dplrratlkn vvehpwmnrg ydfkapsyvp nrvpltpemi dsqvlkemyr lefiddiedt 421 rrslirlvte keyiqlsqey wdklsnakgl ssslnnnyln staqqtliqn hitsnpsqsg 481 ynepdsnfed ptlayhplls iyhlvsemva rklaklqrrq alalqaqaqq rqqqqqvalg 541 tkvalnnnsp dimtkmrspq kevvpnpgif qvpaigtsgt snntntsnkp plhvmvppkl 601 tipeqahtsp tsrkssdiht elngvlkstp vpvsgeyqqr saspvvgehq ekntiggifr 661 risqsgqsqh ptrqqeplpe repptymsks neisikvpks hsrtisdyip sarrypsyvp 721 nsvdvkqkpa knttiappir svsqkqnsdl palpqnaeli vqkqrqkllq enldklqind 781 ndnnnvnavv dginndnsdh ylsvpkgrkl hpsaraksvg harreslkft rppipaalpp 841 sdmtndngfl geankerynp vssnfstvpe dsttysndtn nrltsvysqe ltekqileea 901 skappgsmps idypksmflk gffsvqttss kplpivrhni isvltrmnid fkevkggfic 961 vqqrpsieta avpvitttgv gldsgkamdl qnsldsqlss syhstassas rnssikrqgs 1021 ykrgqnnipl tplatnthqr nssipmspny gnqsngtsge lssmsldyvq qqddilttsr 1081 aqninnvngq teqtntsgik erppikfeih ivkvrivgla gvhfkkvsgn twlykelasy 1141 ilkelnl // LOCUS NP_013198 344 aa linear PLN 30-JUN-2025 DEFINITION SCF ubiquitin ligase complex subunit HRT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013198 VERSION NP_013198.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181984.1 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09413. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..344 /product="SCF ubiquitin ligase complex subunit HRT3" /calculated_mol_wt="40344" Region 100..142 /region_name="F-box_SF" /note="F-box domain superfamily; cl45894" /db_xref="CDD:459239" Site order(103..104,106..108,111..112,118,129..131,133,136) /site_type="other" /note="F-box motif" /db_xref="CDD:438852" Site order(103,107,110..111,117..118,122,124..125,129..131,133) /site_type="other" /note="Skp1 binding site [polypeptide binding]" /db_xref="CDD:438852" Region 178..>252 /region_name="FBO_C" /note="F-box only protein C-terminal region; pfam19270" /db_xref="CDD:466021" CDS 1..344 /gene="HRT3" /locus_tag="YLR097C" /coded_by="NM_001181984.1:1..1035" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:10582239|PMID:14747994]" /experiment="EXISTENCE:genetic interaction:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:10582239]" /experiment="EXISTENCE:mutant phenotype:GO:0071406 cellular response to methylmercury [PMID:17141224]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994|PMID:17141224]" /note="Putative SCF-ubiquitin ligase F-box protein; based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies" /db_xref="GeneID:850786" /db_xref="SGD:S000004087" ORIGIN 1 mivdyekdpr akeaiaiwek gvlkekdgsm sdainfyrsa lkihdnvesl yrkkildewm 61 lhkklsglsm ttdapdeqne tgkddlsvee naelqpcwil eilpddillr iikkvilmsg 121 eswvnlsmtc stfsklcfhd svpfktfaky iyskqiydkm amdlngitdi ntfekeiwrg 181 ddyrmlrerp yikfegvyis vvnyvrygsn aesslsllkp vhmityyryf rfyengqclr 241 llstdepsav vkhfskenkp rhshmcywsl gfdydfghlk itrsdekytf ieefqiknqg 301 nkryqrlkwl ssivvdkegn asncslrnek sfffsrvksf kdpg // LOCUS NP_013199 648 aa linear PLN 30-JUN-2025 DEFINITION Cha4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013199 VERSION NP_013199.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181985.1 REFERENCE 1 (residues 1 to 648) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 648) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 648) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 648) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09414. Method: conceptual translation. FEATURES Location/Qualifiers source 1..648 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..648 /product="Cha4p" /calculated_mol_wt="74262" Site order(39,43,48..51,53,56,65) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Region 43..78 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(44,47,54,60,63,70) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 214..473 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..648 /gene="CHA4" /locus_tag="YLR098C" /gene_synonym="SIL2; SIL3" /coded_by="NM_001181985.1:1..1947" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:30520011]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:8889513]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0009063 amino acid catabolic process [PMID:8889513]" /experiment="EXISTENCE:mutant phenotype:GO:0045893 positive regulation of DNA-templated transcription [PMID:8889513]" /note="DNA binding transcriptional activator; mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain" /db_xref="GeneID:850787" /db_xref="SGD:S000004088" ORIGIN 1 mmlepspppl tttvtpslps slkksvtdnd qnnnnvprkr klacqncrrr rrkcnmekpc 61 sncikfrtec vftqqdlrnk rysttyveal qsqirslkeq lqilssssst iasnalsslk 121 nnsdhgdapn ekilkygeta qsalpssesn denesdaftk kmpsespppv gtnsiypsns 181 lsiikkktdg stryqqqqvs lknlsrspli lrslslffkw lypghylfih retflsaffg 241 dtntksyycs eelvfaiaal gslisykset elfqqsevfy qraktivlkk ifqledssla 301 esssssklai iqtllclafy digsgenpma wylsglafri aheiglhlnp eawsnvyede 361 lsimdfevrs riywgcyiad hliailfgrs tslrlsnstv petdelpeie tgieeyiydp 421 kvilstanpl kklivlsrit eifaskifsp netllqrsey lakfnlevyn wrrdlppelq 481 wtkrslmemt dfnptiayvw fhyyivlisy nkpfiyeikq srelvegyvd elyyllkvwk 541 nkfktfekat iymiysaila iqcmksnlik kdrkqdflnf lsaptlnyel arkfiensed 601 alhnsetmdl lgtlshgndf aleynfdftl lneidmligg ntndglsk // LOCUS NP_013200 394 aa linear PLN 30-JUN-2025 DEFINITION lysophosphatidic acid acyltransferase ICT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013200 VERSION NP_013200.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181986.1 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09415. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..394 /product="lysophosphatidic acid acyltransferase ICT1" /EC_number="2.3.1.51" /calculated_mol_wt="45010" Region <53..388 /region_name="PLN02894" /note="hydrolase, alpha/beta fold family protein" /db_xref="CDD:215484" CDS 1..394 /gene="ICT1" /locus_tag="YLR099C" /coded_by="NM_001181986.1:1..1185" /experiment="EXISTENCE:direct assay:GO:0042171 lysophosphatidic acid acyltransferase activity [PMID:18252723]" /experiment="EXISTENCE:mutant phenotype:GO:0006654 phosphatidic acid biosynthetic process [PMID:18252723]" /note="Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication; human ABHD5 can complement ict1 null mutant" /db_xref="GeneID:850788" /db_xref="SGD:S000004089" ORIGIN 1 mwtntfkwcs kteketttad akvcasvqgl kalqqqimds ttvrgsvnnt mtpgginqwh 61 fhnkrankvc tptvlihgya assmafyrtf enlsdnikdl yaidlpanga seapalqvnk 121 tkkikslrfk hieddvvipv iekrppaedi kshleqyesy fvdrieqwrk dnklrkinvv 181 ghsfggyisf kyalkypdsi eklclisplg vensihaith kwepnttypl tftdpssryy 241 trklnvprfi fenqlnvlkw mgpigsklcs nyistayvkv pdqiykdyll hsfvgknqtv 301 qpqtikvfth lfernliard piinnvrfln patpvmfmyg ehdwmdkyag ylttesmlkn 361 kakasyvevp daghnlfldn pqhfasslvs flsk // LOCUS NP_076901 87 aa linear PLN 30-JUN-2025 DEFINITION Mim2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_076901 VERSION NP_076901.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184484.1 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09416. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..87 /product="Mim2p" /calculated_mol_wt="9854" Region 41..84 /region_name="Mim2" /note="Mitochondrial import 2; pfam19117" /db_xref="CDD:436982" CDS 1..87 /gene="MIM2" /locus_tag="YLR099W-A" /coded_by="NM_001184484.1:1..264" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:22467864]" /experiment="EXISTENCE:direct assay:GO:0140595 MIM complex [PMID:22467864]" /experiment="EXISTENCE:genetic interaction:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:22467864]" /experiment="EXISTENCE:genetic interaction:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:22467864]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:22467864]" /experiment="EXISTENCE:physical interaction:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:22467864]" /experiment="EXISTENCE:physical interaction:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:22467864]" /experiment="EXISTENCE:physical interaction:GO:0140595 MIM complex [PMID:22467864]" /note="Mitochondrial protein required for outer membrane protein import; involved in import of the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and Fzo1p; component of a large protein complex in the outer membrane that includes Mim1p and functions as cation-selective channel for translocation of positively charged precursor segments; not essential in W303 strain background" /db_xref="GeneID:850789" /db_xref="SGD:S000007618" ORIGIN 1 madsedtsvi lqgidtinsv egleedgyls dedtslsnel adaqrqwees lqqlnkllnw 61 vllpllgkyi grrmaktlws rfiehfv // LOCUS NP_013201 347 aa linear PLN 30-JUN-2025 DEFINITION 3-keto-steroid reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013201 VERSION NP_013201.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181987.1 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09417. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..347 /product="3-keto-steroid reductase" /EC_number="1.1.1.270" /calculated_mol_wt="39594" Region 3..293 /region_name="3KS_SDR_c" /note="3-keto steroid reductase, classical (c) SDRs; cd08941" /db_xref="CDD:187645" Site order(10,12..15,39..41,54..56,102..104,152,178..180,202, 206,232..235,237..238) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:187645" Site order(153,180,202,206) /site_type="active" /db_xref="CDD:187645" CDS 1..347 /gene="ERG27" /locus_tag="YLR100W" /coded_by="NM_001181987.1:1..1044" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12119386|PMID:26928762|PMID:11279045]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12119386]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093]" /experiment="EXISTENCE:mutant phenotype:GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity [PMID:10535978]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:10535978]" /note="3-keto sterol reductase; catalyzes last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; Erg27 protein is mainly ER-localized in strains devoid of mtDNA (rho cells); mutants are sterol auxotrophs; mutation is functionally complemented by human HSD17B7" /db_xref="GeneID:850790" /db_xref="SGD:S000004090" ORIGIN 1 mnrkvaivtg tnsnlglniv frlietedtn vrltivvtsr tlprvqevin qikdfynksg 61 rvedleidfd yllvdftnmv svlnayydin kkyrainylf vnaaqgifdg idwigavkev 121 ftnpleavtn ptykiqlvgv kskddmglif qanvfgpyyf iskilpqltr gkayivwiss 181 imsdpkylsl ndiellktna syegskrlvd llhlatykdl kklginqyvv qpgiftshsf 241 seylnfftyf gmlclfylar llgspwhnid gykaanapvy vtrlanpnfe kqdvkygsat 301 srdgmpyikt qeidptgmsd vfayiqkkkl ewdeklkdqi vetrtpi // LOCUS NP_013203 265 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit 9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013203 VERSION NP_013203.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181989.1 REFERENCE 1 (residues 1 to 265) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 265) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 265) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 265) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09418. Method: conceptual translation. FEATURES Location/Qualifiers source 1..265 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..265 /product="anaphase promoting complex subunit 9" /calculated_mol_wt="30725" Region <91..170 /region_name="ANAPC9" /note="Anaphase-promoting complex subunit 9; pfam12856" /db_xref="CDD:403916" CDS 1..265 /gene="APC9" /locus_tag="YLR102C" /coded_by="NM_001181989.1:1..798" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:12574115]" /experiment="EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:12399376]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:12574115]" /note="Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition" /db_xref="GeneID:850792" /db_xref="SGD:S000004092" ORIGIN 1 mnqngdkneg klfqlpslpp wktprfnkan fnnfttplrk rstrvindds mpitgevlee 61 rtaddlygin mdvdevdyln tlshieeekq ydyspfcern tlresridsf lkaeraahcl 121 vfhkvghldg idsyrpdidi mcgeeankyd sanpegngsm llesvpgcnk edlerlsrre 181 fvtnskpnmr rlddiinhet nalksfwnds glvnslqshh lheeylllqe elknvykikc 241 hdrvpieslr dkcrrhysne dssfl // LOCUS NP_013204 650 aa linear PLN 30-JUN-2025 DEFINITION DNA replication initiation factor CDC45 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013204 VERSION NP_013204.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181990.1 REFERENCE 1 (residues 1 to 650) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 650) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 650) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 650) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09419. Method: conceptual translation. FEATURES Location/Qualifiers source 1..650 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..650 /product="DNA replication initiation factor CDC45" /calculated_mol_wt="74118" Region 28..644 /region_name="CDC45" /note="CDC45-like protein; pfam02724" /db_xref="CDD:460663" CDS 1..650 /gene="CDC45" /locus_tag="YLR103C" /gene_synonym="SLD4" /coded_by="NM_001181990.1:1..1953" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:15494305|PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:12019222]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:23382391]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8901577]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851|PMID:9335335]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:2044962]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:23382391]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:2044962]" /note="DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; binds tightly to ssDNA, which disrupts interaction with the MCM helicase and stalls it during replication stress; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes" /db_xref="GeneID:850793" /db_xref="SGD:S000004093" ORIGIN 1 myygisqfse aynkilrnss shsscqlvif vsclnidalc atkmlsllfk kqlvqsqivp 61 ifgyselrrh ysqlddnins lllvgfggvi dleafleidp qeyvidtdek sgeqsfrrdi 121 yvldahrpwn ldnifgsqii qcfddgtvdd tlgeqkeayy klleldeesg ddelsgdend 181 nnggddeatd adevtdedee dedetisnkr gnssigpndl skrkqrkkqi heyegvleey 241 ysqgttvvns isaqiyslls aigetnlsnl wlnilgttsl diayaqvynr lypllqdevk 301 rltpssrnsv ktpdtltlni qpdyylfllr hsslydsfyy snyvnaklsl wnengkkrlh 361 kmfarmgipl staqetwlym dhsikrelgi ifdknldryg lqdiirdgfv rtlgyrgsis 421 asefvealta llevgnstdk dsvkinndnn ddtdgeeeed nsaqkltnlr krwvsnfwls 481 wdalddrkve llnrgiqlaq dlqraifntg vailekklik hlriyrlcvl qdgpdldlyr 541 npltllrlgn wlieccaese dkqllpmvla sidentdtyl vagltprypr gldtihtkkp 601 ilnnfsmafq qitaetdakv ridnfessii eirredlspf lekltlsgll // LOCUS NP_013205 131 aa linear PLN 30-JUN-2025 DEFINITION Lcl2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013205 VERSION NP_013205.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181991.1 REFERENCE 1 (residues 1 to 131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 131) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09420. Method: conceptual translation. FEATURES Location/Qualifiers source 1..131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..131 /product="Lcl2p" /calculated_mol_wt="14791" Region 41..99 /region_name="LCL2-like" /note="Long chronological lifespan protein 2 and similar proteins; cd23996" /db_xref="CDD:467939" CDS 1..131 /gene="LCL2" /locus_tag="YLR104W" /coded_by="NM_001181991.1:1..396" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:19325107]" /note="hypothetical protein; mutant is deficient in cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD); SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole" /db_xref="GeneID:850794" /db_xref="SGD:S000004094" ORIGIN 1 msqsrwsivl ifalfifgst gvnaffnfgh hqqqqqqqqq syedqvlnnp cdgylcpdtl 61 tcvaqqkdcp cpfpksqlkc vlpdnkfvci skpathnekf raiyddpvkg pkaknkgfrd 121 cgwvsdaykn h // LOCUS NP_013206 377 aa linear PLN 30-JUN-2025 DEFINITION tRNA splicing endonuclease subunit SEN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013206 VERSION NP_013206.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181992.1 REFERENCE 1 (residues 1 to 377) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 377) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 377) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 377) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09421. Method: conceptual translation. FEATURES Location/Qualifiers source 1..377 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..377 /product="tRNA splicing endonuclease subunit SEN2" /EC_number="4.6.1.16" /calculated_mol_wt="43978" Region 137..>185 /region_name="BAR" /note="The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; cl12013" /db_xref="CDD:472257" Region 171..343 /region_name="endA" /note="tRNA-intron lyase; TIGR00324" /db_xref="CDD:129424" CDS 1..377 /gene="SEN2" /locus_tag="YLR105C" /coded_by="NM_001181992.1:1..1134" /experiment="EXISTENCE:direct assay:GO:0000213 tRNA-intron lyase activity [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0000214 tRNA-intron endonuclease complex [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0000379 tRNA-type intron splice site recognition and cleavage [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:12925762|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:mutant phenotype:GO:0000213 tRNA-intron lyase activity [PMID:2182322]" /experiment="EXISTENCE:mutant phenotype:GO:0000379 tRNA-type intron splice site recognition and cleavage [PMID:2182322]" /experiment="EXISTENCE:mutant phenotype:GO:0005741 mitochondrial outer membrane [PMID:12925762]" /note="Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease; localizes to the peroxisome in a Pex5p-dependent manner in oleate" /db_xref="GeneID:850795" /db_xref="SGD:S000004095" ORIGIN 1 mskgrvnqkr ykyplpihpv ddlpelilhn plswlywayr yykstnalnd kvhvdfigdt 61 tlhitvqddk qmlylwnngf fgtgqfsrse ptwkartear lglndtplhn rggtksntet 121 emtlekvtqq rrlqrlefkk eraklerell elrkkgghid eenillekqr eslrkfklkq 181 tedvgivaqq qdisesnlrd ednnlldeng dllpleslel mpveamfltf alpvldispa 241 clagklfqfd akykdihsfv rsyviyhhyr shgwcvrsgi kfgcdyllyk rgppfqhaef 301 cvmgldhdvs kdytwyssia rvvggakktf vlcyverlis eqeaialwks nnftklfnsf 361 qvgevlykrw vpgrnrd // LOCUS NP_013207 4910 aa linear PLN 30-JUN-2025 DEFINITION AAA family ATPase midasin [Saccharomyces cerevisiae S288C]. ACCESSION NP_013207 VERSION NP_013207.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181993.1 REFERENCE 1 (residues 1 to 4910) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 4910) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 4910) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 4910) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 4910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 4910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 4910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 4910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 4910) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09422. Method: conceptual translation. FEATURES Location/Qualifiers source 1..4910 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..4910 /product="AAA family ATPase midasin" /calculated_mol_wt="559179" Region 310..427 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site order(320..322,340,342..343,385..386) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:410865" Region 465..579 /region_name="AAA_lid_7" /note="Midasin AAA lid domain; pfam17867" /db_xref="CDD:465540" Region 648..>703 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Region <811..896 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Region 910..1015 /region_name="AAA_lid_5" /note="Midasin AAA lid domain; pfam17865" /db_xref="CDD:407722" Region 1078..1214 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site 1083..1090 /site_type="other" /note="Walker A motif" /db_xref="CDD:99707" Site order(1084..1091,1150,1194) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:99707" Site 1146..1151 /site_type="other" /note="Walker B motif" /db_xref="CDD:99707" Site 1213 /site_type="other" /note="arginine finger" /db_xref="CDD:99707" Region 1226..1320 /region_name="AAA_lid_7" /note="Midasin AAA lid domain; pfam17867" /db_xref="CDD:465540" Region 1363..1558 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site 1368..1375 /site_type="other" /note="Walker A motif" /db_xref="CDD:99707" Site 1369..1376 /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:99707" Region 1742..1879 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site 1747..1754 /site_type="other" /note="Walker A motif" /db_xref="CDD:99707" Site order(1748..1755,1815,1860) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:99707" Site 1811..1816 /site_type="other" /note="Walker B motif" /db_xref="CDD:99707" Site 1874 /site_type="other" /note="arginine finger" /db_xref="CDD:99707" Region 1891..1990 /region_name="AAA_lid_7" /note="Midasin AAA lid domain; pfam17867" /db_xref="CDD:465540" Region <2190..2276 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Region <4046..4671 /region_name="MDN1" /note="Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]; COG5271" /db_xref="CDD:444083" Region 4643..4910 /region_name="vWA_midasin" /note="VWA_Midasin: Midasin is a member of the AAA ATPase family. The proteins of this family are unified by their common archetectural organization that is based upon a conserved ATPase domain. The AAA domain of midasin contains six tandem AAA protomers. The...; cd01460" /db_xref="CDD:238737" Site order(4710,4712,4714,4781,4814) /site_type="active" /note="metal ion dependent adhesion site (MIDAS) [active]" /db_xref="CDD:238737" CDS 1..4910 /gene="REA1" /locus_tag="YLR106C" /gene_synonym="MDN1" /coded_by="NM_001181993.1:1..14733" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12102729]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15528184]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:30460895]" /experiment="EXISTENCE:direct assay:GO:0110136 protein-RNA complex remodeling [PMID:20542003]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15528184]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12837249]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:30460895]" /experiment="EXISTENCE:mutant phenotype:GO:0110136 protein-RNA complex remodeling [PMID:20542003|PMID:24240281]" /experiment="EXISTENCE:mutant phenotype:GO:2000200 regulation of ribosomal subunit export from nucleus [PMID:24240281]" /note="Huge dynein-related AAA-type ATPase (midasin); forms extended pre-60S particle with the Rix1 complex; involved with interaction partners Rsa4p and Ytm1p, in the ATP-dependent remodeling of the pre-60S particle at successive maturation steps during ribosomal biogenesis; involved in the removal of biogenesis factors including GTPase Nog2p prior to nuclear export; contains a hexameric AAA-motor head domain and a long flexible tail with a MIDAS (metal ion-dependent adhesion site) domain" /db_xref="GeneID:850796" /db_xref="SGD:S000004096" ORIGIN 1 msqdrilldl dvvnqrlilf nsafpsdaie apfhfsnkes tsenldnlag tilhsrsitg 61 hvflykhifl eivarwikds kkkdyvlvie klasiitifp vampliedyl dkendhfiti 121 lqnpstqkds dmfkillayy rllyhnkevf arfiqpdily qlvdlltkeq enqvviflal 181 kvlslyldmg ektlndmldt yiksrdsllg hfegdsgidy sflelneakr canfsklpsv 241 pecftiekks syfiiepqdl stkvasicgv ivpkvhtihd kvfypltfvp thktvsslrq 301 lgrkiqnstp imligkagsg ktflinelsk ymgchdsivk ihlgeqtdak lligtytsgd 361 kpgtfewrag vlatavkegr wvliedidka ptdvlsills llekreltip srgetvkaan 421 gfqlistvri nedhqkdssn kiynlnmigm riwnvielee pseedlthil aqkfpiltnl 481 ipklidsykn vksiymntkf islnkgahtr vvsvrdlikl cerldilfkn nginkpdqli 541 qssvydsifs eaadcfagai gefkalepii qaigesldia ssrislfltq hvptlenldd 601 sikigravll keklniqkks mnstlfaftn hslrlmeqis vciqmtepvl lvgetgtgkt 661 tvvqqlakml akkltvinvs qqtetgdllg gykpvnsktv avpiqenfet lfnatfslkk 721 nekfhkmlhr cfnknqwknv vklwneaykm aqsilkitnt enenenakkk krrlnthekk 781 llldkwadfn dsvkkfeaqs ssiensfvfn fvegslvkti ragewlllde vnlatadtle 841 sisdlltepd srsillsekg daepikahpd frifacmnpa tdvgkrdlpm girsrfteiy 901 vhsperditd llsiidkyig kysvsdewvg ndiaelylea kklsdnntiv dgsnqkphfs 961 irtltrtlly vtdiihiygl rrslydgfcm sfltlldqks eailkpviek ftlgrlknvk 1021 simsqtppsp gpdyvqfkhy wmkkgpntiq eqahyiitpf veknmmnlvr atsgkrfpvl 1081 iqgptssgkt smikyladit ghkfvrinnh ehtdlqeylg tyvtddtgkl sfkegvlvea 1141 lrkgywivld elnlaptdvl ealnrllddn relfipetqe vvhphpdfll fatqnppgiy 1201 ggrkilsraf rnrflelhfd dipqdeleii lrercqiaps yakkivevyr qlsiersasr 1261 lfeqknsfat lrdlfrwalr davgyeqlaa sgymllaerc rtpqekvtvk ktlekvmkvk 1321 ldmdqyyasl edksleaigs vtwtkgmrrl svlvssclkn kepvllvget gcgktticql 1381 laqfmgreli tlnahqntet gdilgaqrpv rnrseiqykl ikslktalni andqdvdlke 1441 llqlysksdn kniaedvqle iqklrdslnv lfewsdgpli qamrtgnffl ldeisladds 1501 vlerlnsvle perslllaeq gssdslvtas enfqffatmn pggdygkkel spalrnrfte 1561 iwvpsmedfn dvnmivssrl ledlkdlanp ivkfsewfgk klgggnatsg vislrdilaw 1621 vefinkvfpk iqnkstaliq gasmvfidal gtnntaylae nendlkslrt eciiqllklc 1681 gddlelqqie tneiivtqde lqvgmfkipr fpdaqsssfn ltapttasnl vrvvramqvh 1741 kpillegspg vgktslital anitgnkltr inlseqtdlv dlfgadapge rsgeflwhda 1801 pflramkkge wvlldemnla sqsvleglna cldhrgeayi peldisfsch pnflvfaaqn 1861 pqyqgggrkg lpksfvnrfs vvfidmltsd dllliakhly psiepdiiak miklmstled 1921 qvckrklwgn sgspwefnlr dtlrwlklln qysicedvdv fdfvdiivkq rfrtisdknk 1981 aqlliedifg kfstkenffk ltedyvqinn evalrnphyr ypitqnlfpl ecnvavyesv 2041 lkainnnwpl vlvgpsnsgk tetirflasi lgprvdvfsm nsdidsmdil ggyeqvdltr 2101 qisyiteelt nivreiismn mklspnatai meglnllkyl lnnivtpekf qdfrnrfnrf 2161 fshleghpll ktmsmniekm teiitkeasv kfewfdgmlv kavekghwli ldnanlcsps 2221 vldrlnslle idgsllinec sqedgqprvl kphpnfrlfl tmdpkygels ramrnrgvei 2281 yidelhsrst afdrltlgfe lgenidfvsi ddgikkikln epdmsiplkh yvpsylsrpc 2341 ifaqvhdill lsdeepiees laavipishl gevgkwannv lncteysekk iaerlyvfit 2401 fltdmgvlek innlykpanl kfqkalglhd kqlteetvsl tlneyvlptv skysdkiksp 2461 eslyllsslr lllnslnalk lineksthgk ideltyiels aaafngrhlk nipripifci 2521 lyniltvmse nlkteslfcg snqyqyywdl lviviaalet avtkdearlr vykelidswi 2581 asvksksdie itpflninle ftdvlqlsrg hsitllwdif rknypttsns wlafeklinl 2641 sekfdkvrll qfsesynsik dlmdvfrlln ddvlnnklse fnlllskled ginelelisn 2701 kflnkrkhyf adefdnliry tfsvdtaeli kelapassla tqkltklitn kynyppifdv 2761 lwteknaklt sftstifssq fledvvrksn nlksfsgnqi kqsisdaell lsstikcspn 2821 llksqmeyyk nmllswlrkv idihvggdcl kltlkelcsl ieektasetr vtfaeyifpa 2881 ldlaessksl eelgeawitf gtgllllfvp dspydpaihd yvlydlflkt ktfsqnlmks 2941 wrnvrkvisg deeiftekli ntisdddapq sprvyrtgms idslfdewma flsstmssrq 3001 ikelvssykc nsdqsdrrle mlqqnsahfl nrlesgyskf adlndilagy iysinfgfdl 3061 lklqkskdra sfqisplwsm dpiniscaen vlsayhelsr ffkkgdmedt siekvlmyfl 3121 tlfkfhkrdt nlleifeaal ytlysrwsvr rfrqeqeene ksnmfkfndn sddyeadfrk 3181 lfpdyedtal vtnekdissp enlddiyfkl adtyisvfdk dhdanfssel ksgaiittil 3241 sedlkntrie elksgslsav intldaetqs fkntevfgni dfyhdfsipe fqkagdiiet 3301 vlksvlkllk qwpehatlke lyrvsqefln ypiktplarq lqkieqiyty laewekyass 3361 evslnntvkl itdlivswrk lelrtwkglf nsedaktrks igkwwfylye sivisnfvse 3421 kketapnatl lvsslnlffs kstlgefnar ldlvkafykh iqliglrssk iagllhntik 3481 fyyqfkplid eritngkksl ekeiddiill aswkdvnvda lkqssrkshn nlykivrkyr 3541 dllngdakti ieagllysne nklklptlkq hfyedpnlea sknlvkeist wsmraaplrn 3601 idtvasnmds ylekissqef pnfadlasdf yaeaerlrke tpnvytkenk krlaylktqk 3661 skllgdalke lrriglkvnf rediqkvqss tttilaniap fnneylnssd afffkildll 3721 pklrsaasnp sddipvaaie rgmalaqslm fslitvrhpl seftndycki ngmmldlehf 3781 tclkgdivhs slkanvdnvr lfekwlpsll dyaaqtlsvi skysatseqq killdakstl 3841 ssffvhfnss rifdssfies ysrfelfine llkklenake tgnafvfdii iewikankgg 3901 pikkeqkrgp svedveqafr rtftsiilsf qkvigdgies isetddnwls asfkkvmvnv 3961 kllrssvvsk nietalsllk dfdftttesi yvksvisftl pvitryynam tvvlersriy 4021 ytntsrgmyi lstilhslak ngfcspqpps eevddknlqe gtglgdgega qnnnkdveqd 4081 edltedaqne nkeqqdkder ddeneddave megdmagele dlsngeendd edtdseeeel 4141 deeiddlned dpnaiddkmw ddkasdnske kdtdqnldgk nqeedvqaae ndeqqrdnke 4201 ggdedpnape dgdeeiende naeeendvge qedevkdeeg edleanvpei etldlpedmn 4261 ldseheesde dvdmsdgmpd dlnkeevgne deevkqesgi esdnendepg peedagetet 4321 aldeeegaee dvdmtndegk edeengpeeq amsdeeelkq daameenkek ggeqntegld 4381 gveekadted idqeaavqqd sgskgagada tdtqeqddvg gsgttqntye edqedvtknn 4441 eesreeataa lkqlgdsmke yhrrrqdike aqtngeeden leknnerpde fehvegante 4501 tdtqalgsat qdqlqtided maidddreeq evdqkelved addekmdide eemlsdidah 4561 danndvdskk sgfigkrkse edfenelsne hfsadqedds eiqslienie dnppdasasl 4621 tpersleesr elwhkseist adlvsrlgeq lrlileptla tklkgdyktg krlnmkriip 4681 yiasqfrkdk iwlrrtkpsk rqyqimiald dsksmseskc vklafdslcl vsktltqlea 4741 gglsivkfge nikevhsfdq qfsnesgara fqwfgfqetk tdvkklvaes tkiferaram 4801 vhndqwqlei visdgicedh etiqklvrra renkimlvfv iidgitsnes ildmsqvnyi 4861 pdqygnpqlk itkyldtfpf efyvvvhdis elpemlslil rqyftdlass // LOCUS NP_013208 404 aa linear PLN 30-JUN-2025 DEFINITION RNA exonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_013208 VERSION NP_013208.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181994.1 REFERENCE 1 (residues 1 to 404) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 404) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 404) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 404) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09423. Method: conceptual translation. FEATURES Location/Qualifiers source 1..404 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..404 /product="RNA exonuclease" /calculated_mol_wt="45749" Region 244..390 /region_name="REX1_like" /note="DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins; cd06145" /db_xref="CDD:99848" Site order(247..250,252,327..328,330..332,376,381) /site_type="active" /db_xref="CDD:99848" Site order(247..250,252,327..328,330..331,376,381) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:99848" Site order(247,249,332,376,381) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:99848" CDS 1..404 /gene="REX3" /locus_tag="YLR107W" /coded_by="NM_001181994.1:1..1215" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10716935]" /experiment="EXISTENCE:genetic interaction:GO:0034476 U5 snRNA 3'-end processing [PMID:10716935]" /experiment="EXISTENCE:mutant phenotype:GO:0000175 3'-5'-RNA exonuclease activity [PMID:10716935]" /experiment="EXISTENCE:mutant phenotype:GO:0043628 regulatory ncRNA 3'-end processing [PMID:10716935]" /note="RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases" /db_xref="GeneID:850797" /db_xref="SGD:S000004097" ORIGIN 1 mgsllrpvdl vnqplgfqer ykilqklfkq lqkayahtkg tnidlerlat rlevhvakns 61 lsgqsykfnm sillrdvlky kgdlskikin grplkgakph lssignansi ttkskameal 121 kalildskvl ekngyivkem qnktnddnst qlyapclrcs snfkktdime ktlcryhplk 181 riynrdtknh qypccgettd svsflrlgck tffhhvfrge sydelckisk fsstddidgv 241 envlsldcem aftslgyemi rltivdfftg ktlfdhviqp igdivdlnsd fsgvheidrt 301 ncptykeald vflsenlink nsilighgle ndlnvmrlfh nkvidtaily srtkfkvslk 361 nlafevlsrk iqngehdssq daiatmdvvk vkigispsqn kwek // LOCUS NP_013209 485 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR108C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013209 VERSION NP_013209.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181995.1 REFERENCE 1 (residues 1 to 485) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 485) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 485) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 485) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 485) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 485) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 485) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 485) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 485) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09424. Method: conceptual translation. FEATURES Location/Qualifiers source 1..485 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..485 /product="uncharacterized protein" /calculated_mol_wt="55470" Region 28..104 /region_name="BTB_POZ_KCTD-like" /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; cd18316" /db_xref="CDD:349625" Region 122..212 /region_name="BTB_POZ" /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; cl38908" /db_xref="CDD:453885" CDS 1..485 /locus_tag="YLR108C" /coded_by="NM_001181995.1:1..1458" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene; protein abundance increases in response to DNA replication stress; YLR108C has a paralog, YDR132C, that arose from the whole genome duplication" /db_xref="GeneID:850798" /db_xref="SGD:S000004098" ORIGIN 1 msgqkgeivv ytkelettpe llpnhevfki rigqklfeis gatlnsdapn fftqffnthd 61 kntilfvdrs edvfiiiyrh lqgyfpdikn evqftclfad alyfqlpklv klikeydyhf 121 tniggvpfkv pkslfheegn rlnyfetisr isyeeiekwe snkkpgfppl lppsyiarsp 181 effrdilsll ggsklelsee rtaslikecr yyrlnrleqe lvrakiiynp ltncqevcia 241 ldsvskkgvt ierltslhtg nqslavsscl ngtegekaat gfhktetdsg nndeyepptk 301 kvkhcierhw smlkyqrpyi dtvshdlifq lhsnqckiif nkknktvhvd lsreaavlfe 361 nkfsdvllen pdfkidlsey kvklrdsqmq veshliipac vsicdltvng akccnifslv 421 ndskckgrvl dctnlkvlnc vhglklhlsk smwklgtnng riilvavkae tfsgtkeyck 481 midfl // LOCUS NP_013210 176 aa linear PLN 30-JUN-2025 DEFINITION thioredoxin peroxidase AHP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013210 VERSION NP_013210.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181996.1 REFERENCE 1 (residues 1 to 176) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 176) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 176) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 176) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09425. Method: conceptual translation. FEATURES Location/Qualifiers source 1..176 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..176 /product="thioredoxin peroxidase AHP1" /EC_number="1.11.1.24" /calculated_mol_wt="18984" Region 5..174 /region_name="PRX5_like" /note="Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; cd03013" /db_xref="CDD:239311" Site order(59,62,141) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:239311" Site order(60,93,95,118..119,138) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:239311" CDS 1..176 /gene="AHP1" /locus_tag="YLR109W" /coded_by="NM_001181996.1:1..531" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10681558]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0008379 thioredoxin peroxidase activity [PMID:10681558]" /experiment="EXISTENCE:direct assay:GO:0045454 cell redox homeostasis [PMID:10681558]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:15051715]" /experiment="EXISTENCE:mutant phenotype:GO:0008379 thioredoxin peroxidase activity [PMID:10681558]" /experiment="EXISTENCE:mutant phenotype:GO:0010038 response to metal ion [PMID:12270680]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:10681558]" /note="Thiol-specific peroxiredoxin; reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p" /db_xref="GeneID:850799" /db_xref="SGD:S000004099" ORIGIN 1 msdlvnkkfp agdykfqyia isqsdadses ckmpqtvews klisenkkvi itgapaafsp 61 tctvshipgy inyldelvke kevdqvivvt vdnpfanqaw akslgvkdtt hikfasdpgc 121 aftksigfel avgdgvywsg rwamvvengi vtyaaketnp gtdvtvssve svlahl // LOCUS NP_013211 133 aa linear PLN 30-JUN-2025 DEFINITION Ccw12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013211 VERSION NP_013211.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001181997.1 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09426. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..133 /product="Ccw12p" /calculated_mol_wt="12926" Region 32..75 /region_name="Flocculin_t3" /note="Flocculin type 3 repeat; pfam13928" /db_xref="CDD:464047" CDS 1..133 /gene="CCW12" /locus_tag="YLR110C" /coded_by="NM_001181997.1:1..402" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:21320323]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:21320323]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:10322008|PMID:21320323]" /experiment="EXISTENCE:mutant phenotype:GO:0000752 agglutination involved in conjugation with cellular fusion [PMID:10322008]" /experiment="EXISTENCE:mutant phenotype:GO:0005199 structural constituent of cell wall [PMID:17315267|PMID:21320323]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10322008|PMID:15972461|PMID:21320323]" /note="Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication" /db_xref="GeneID:850800" /db_xref="SGD:S000004100" ORIGIN 1 mqfstvasia avaavasaaa nvttatvsqe sttlvtitsc edhvcsetvs palvstatvt 61 vddvitqytt wcpltteapk ngtstaapvt steapkntts aapthsvtsy tgaaakalpa 121 agallagaaa lll // LOCUS NP_001335794 110 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR111W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335794 VERSION NP_001335794.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348854.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80314. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..110 /product="uncharacterized protein" /calculated_mol_wt="12524" CDS 1..110 /locus_tag="YLR111W" /coded_by="NM_001348854.1:1..333" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:850801" /db_xref="SGD:S000004101" ORIGIN 1 mgnsktngff tpekylygii qglpptlrgl afiffflvaf yffpafwdlc gvlrgargkg 61 fpkrksdans qhskqfwths dfpiwflrvl iptrasinsm kyphtaalvr // LOCUS NP_001335795 139 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR112W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335795 VERSION NP_001335795.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348855.1 REFERENCE 1 (residues 1 to 139) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 139) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 139) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 139) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80315. Method: conceptual translation. FEATURES Location/Qualifiers source 1..139 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..139 /product="uncharacterized protein" /calculated_mol_wt="15788" CDS 1..139 /locus_tag="YLR112W" /coded_by="NM_001348855.1:1..420" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:850802" /db_xref="SGD:S000004102" ORIGIN 1 mggrsaqprr fsfacrilhp avahdamags ryilrapasi irlaqhgwlh cclhfflfpa 61 mndvcfvakg salylftvei ivfgspslrh nvlsffyfal pwfkrqcrlk vnfnrlkeir 121 giaqvvrkaf fisktlpci // LOCUS NP_013214 435 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase HOG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013214 VERSION NP_013214.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182000.1 REFERENCE 1 (residues 1 to 435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 435) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09427. Method: conceptual translation. FEATURES Location/Qualifiers source 1..435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..435 /product="mitogen-activated protein kinase HOG1" /EC_number="2.7.11.24" /calculated_mol_wt="48727" Region 12..339 /region_name="STKc_Sty1_Hog1" /note="Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1; cd07856" /db_xref="CDD:270843" Site order(29..32,34..35,37,50,52,69,83,100..103,106,108..109, 144,146,148..149,151,161..162,165,174,176..179,181,219) /site_type="active" /db_xref="CDD:270843" Site order(29..32,34..35,37,50,52,83,100..103,106,109,146, 148..149,151,161..162) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270843" Site order(69,108,144,146,165,174,176..179,181,219) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270843" Site order(80,104..105,110,120,123,130,152..156,305,307,310) /site_type="other" /note="KIM docking site [polypeptide binding]" /db_xref="CDD:270843" Site 161..181 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270843" CDS 1..435 /gene="HOG1" /locus_tag="YLR113W" /gene_synonym="SSK3" /coded_by="NM_001182000.1:1..1308" /experiment="EXISTENCE:direct assay:GO:0001100 negative regulation of exit from mitosis [PMID:32265285]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:24508389]" /experiment="EXISTENCE:direct assay:GO:0004707 MAP kinase activity [PMID:10805732|PMID:32265285]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10817757]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:10817757]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:23178807]" /experiment="EXISTENCE:direct assay:GO:0033262 regulation of nuclear cell cycle DNA replication [PMID:23178807]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12743037]" /experiment="EXISTENCE:direct assay:GO:0071470 cellular response to osmotic stress [PMID:23178807|PMID:24508389|PMID:12743037|PMID:10805732]" /experiment="EXISTENCE:direct assay:GO:0071474 cellular hyperosmotic response [PMID:32265285]" /experiment="EXISTENCE:mutant phenotype:GO:0006972 hyperosmotic response [PMID:7681220]" /experiment="EXISTENCE:mutant phenotype:GO:0007231 osmosensory signaling pathway [PMID:7681220]" /experiment="EXISTENCE:mutant phenotype:GO:0016241 regulation of macroautophagy [PMID:16874103]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:23435728|PMID:24508389]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:23435728|PMID:24508389|PMID:16874103]" /experiment="EXISTENCE:physical interaction:GO:0005516 calmodulin binding [PMID:27421986]" /experiment="EXISTENCE:physical interaction:GO:0071474 cellular hyperosmotic response [PMID:27421986]" /note="Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress" /db_xref="GeneID:850803" /db_xref="SGD:S000004103" ORIGIN 1 mttneefirt qifgtvfeit nryndlnpvg mgafglvcsa tdtltsqpva ikkimkpfst 61 avlakrtyre lkllkhlrhe nliclqdifl splediyfvt elqgtdlhrl lqtrplekqf 121 vqyflyqilr glkyvhsagv ihrdlkpsni linencdlki cdfglariqd pqmtgyvstr 181 yyrapeimlt wqkydvevdi wsagcifaem iegkplfpgk dhvhqfsiit dllgsppkdv 241 inticsentl kfvtslphrd pipfserfkt vepdavdlle kmlvfdpkkr itaadalahp 301 ysapyhdptd epvadakfdw hfndadlpvd twrvmmysei ldfhkiggsd gqidisatfd 361 dqvaaataaa aqaqaqaqaq vqlnmaahsh ngagttgndh sdiaggnkvs dhvaandtit 421 dygnqaiqya nefqq // LOCUS NP_013215 764 aa linear PLN 30-JUN-2025 DEFINITION Avl9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013215 VERSION NP_013215.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182001.1 REFERENCE 1 (residues 1 to 764) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 764) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 764) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 764) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 764) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09428. Method: conceptual translation. FEATURES Location/Qualifiers source 1..764 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..764 /product="Avl9p" /calculated_mol_wt="86295" Region 9..401 /region_name="Avl9" /note="Transport protein Avl9; pfam09794" /db_xref="CDD:430832" CDS 1..764 /gene="AVL9" /locus_tag="YLR114C" /coded_by="NM_001182001.1:1..2295" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006892 post-Golgi vesicle-mediated transport [PMID:17229886]" /note="Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms; relocalizes from bud neck to cytoplasm upon DNA replication stress" /db_xref="GeneID:850805" /db_xref="SGD:S000004104" ORIGIN 1 mdeheeavif giclvdfhhk rgpeieywyg lpegtqsael wpnlpfqalp dgshsfeetf 61 tyftllyder rqrsppngat dlsddsindn ttlfaiscsr qiksdelvtk dkdvtrstvq 121 kaivvisrqp ifgqikdkls ivtnafflqh dfgdrkiiqs lyenlksiyt paslvrnaen 181 rlyiglclrk ilhdfkrnal vllkaimlek kiivygndve alcnlqfgli slipdlmsnl 241 qdsgspqlfq disklnvvds fkssnresvl rflgfplpif ekgglfspyt plqqmndirs 301 ertlffmigs sntllaeqke elchifvntd nstvdildkt lnpvlqlssh dkkwiesisg 361 ivsdtwnend detpknsqfe gsedfirwqf edyltgllss vklsdyldlh kendqalkti 421 pedmlnsnpv hlfnlnwvqs wketqnflif nsrtddrlfd lfppkhiyng adtlsllqqr 481 flatfhnlkr sssnsssnkn ghqseedikd qesieskksv sqisvnpgkn tdkpaanlwn 541 swkeyfnkpk ntanedvtes tedlknrskt snaiqkammg lglhykpdae tdqqseevgn 601 sednedddtd edsedddddg gddddseddd ddddgegden gddgegdeng ddgegdengd 661 kedsqdfsng ftdvtnintd hdkeneqnfe gnaenfnede tvadkdiegg pesnknsdsk 721 tdiyendrnv edssktrntv kksneeggan daaigncvqd eekl // LOCUS NP_013216 859 aa linear PLN 30-JUN-2025 DEFINITION cleavage polyadenylation factor subunit CFT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013216 VERSION NP_013216.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182002.1 REFERENCE 1 (residues 1 to 859) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 859) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 859) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 859) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09429. Method: conceptual translation. FEATURES Location/Qualifiers source 1..859 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..859 /product="cleavage polyadenylation factor subunit CFT2" /calculated_mol_wt="96123" Site order(13,61,63,65..66,158,179) /site_type="active" /db_xref="CDD:293851" Region 19..211 /region_name="Lactamase_B_6" /note="Metallo-beta-lactamase superfamily domain; pfam16661" /db_xref="CDD:406948" Site order(139..141,150,166,168,173,196) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:293851" Region 254..372 /region_name="Beta-Casp" /note="Beta-Casp domain; smart01027" /db_xref="CDD:214983" Region 732..856 /region_name="CPSF100_C" /note="Cleavage and polyadenylation factor 2 C-terminal; pfam13299" /db_xref="CDD:463836" CDS 1..859 /gene="CFT2" /locus_tag="YLR115W" /gene_synonym="YDH1" /coded_by="NM_001182002.1:1..2580" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9099738]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204|PMID:10523662]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11344258]" /note="Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein." /db_xref="GeneID:850806" /db_xref="SGD:S000004105" ORIGIN 1 mtykynccdd gsgttvgsvv rfdnvtllid pgwnpskvsy eqcikywekv ipeidviils 61 qptieclgah sllyynftsh fisriqvyat lpvinlgrvs tidsyasagv igpydtnkld 121 ledieisfdh ivplkysqlv dlrsrydglt llaynagvcp ggsiwcisty seklvyakrw 181 nhtrdnilna asildatgkp lstlmrpsai ittldrfgss qpfkkrskif kdtlkkglss 241 dgsviipvdm sgkfldlftq vhellfestk inahtqvpvl ilsyargrtl tyaksmlewl 301 spsllktwen rnntspfeig srikiiapne lskypgskic fvsevgalin eviikvgnse 361 kttliltkps fecassldki leiveqdern wktfpedgks flcdnyisid tikeeplske 421 eteafkvqlk ekkrdrnkki llvkreskkl angnaiiddt ngeramrnqd ilvenvngvp 481 pidhimggde dddeeeendn llnllkdnse ksaakkntev pvdiiiqpsa askhkmfpfn 541 pakikkddyg tvvdftmflp ddsdnvnqns rkrplkdgak ttspvneedn kneeedgynm 601 sdpiskrskh rasrysgfsg tgeaenfdnl dylkidktls krtistvnvq lkcsvvilnl 661 qslvdqrsas iiwpslksrk ivlsapkqiq neeitaklik knievvnmpl nkivefstti 721 ktldisidsn ldnllkwqri sdsytvatvv grlvkeslpq vnnhqktasr sklvlkplhg 781 ssrshktgal sigdvrlaql kkllteknyi aefkgegtlv inekvavrki ndaetiidgt 841 pselfdtvkk lvtdmlaki // LOCUS NP_013217 476 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein MSL5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013217 VERSION NP_013217.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182003.1 REFERENCE 1 (residues 1 to 476) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 476) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 476) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 476) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09430. Method: conceptual translation. FEATURES Location/Qualifiers source 1..476 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..476 /product="mRNA splicing protein MSL5" /calculated_mol_wt="52903" Region 1..269 /region_name="MSL5" /note="Splicing factor (branch point binding protein) [RNA processing and modification]; COG5176" /db_xref="CDD:227503" Region <267..386 /region_name="AIR1" /note="Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; COG5082" /db_xref="CDD:227414" Region <363..435 /region_name="PHA03247" /note="large tegument protein UL36; Provisional" /db_xref="CDD:223021" CDS 1..476 /gene="MSL5" /locus_tag="YLR116W" /coded_by="NM_001182003.1:1..1431" /experiment="EXISTENCE:direct assay:GO:0000243 commitment complex [PMID:10376880|PMID:9150140]" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:9182766]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0045131 pre-mRNA branch point binding [PMID:9182766]" /note="Component of commitment complex; which defines first step in splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:850807" /db_xref="SGD:S000004106" ORIGIN 1 msfrrinsry fenrkgssme ekkakvppnv nlslwrkntv esdvhrfnsl pskisgaltr 61 eqiysyqvmf riqeitiklr tndfvppsrk nrspspppvy daqgkrtntr eqryrkkled 121 eriklveial ktipyfvppd dykrptkfqd kyyipvdqyp dvnfvglllg prgrtlrklq 181 edsnckiair grgsvkegkn asdlppgamn fedplhclii adsedkiqkg ikvcqnivik 241 avtspegqnd lkrgqlrela elngtlredn rpcpicglkd hkrydcpnrk ipniqgivck 301 icgqtghfsr dcnsssqrms rfdrnatvnn sapiqsndvh ynsnthpiqa pkrsrydnns 361 tepplkfpas sryapspspp ashisrqaqn vtptpppglt sssfssgvpg iappplqspp 421 eseqpkfslp pppgmttvqs siapppglsg ppgfsnnmgn dinkptppgl qgppgl // LOCUS NP_013218 687 aa linear PLN 30-JUN-2025 DEFINITION Clf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013218 VERSION NP_013218.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182004.1 REFERENCE 1 (residues 1 to 687) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 687) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 687) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 687) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09431. Method: conceptual translation. FEATURES Location/Qualifiers source 1..687 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..687 /product="Clf1p" /calculated_mol_wt="82314" Region <15..196 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 186..211 /region_name="HAT" /note="HAT (Half-A-TPR) repeat; pfam02184" /db_xref="CDD:111114" Region 404..432 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(405,408..409,412..413,415,438,441..442,445..446, 448..449,472,475..476,479..480,483) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 407..>623 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 437..466 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 471..499 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 511..539 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..687 /gene="CLF1" /locus_tag="YLR117C" /gene_synonym="NTC77; SYF3" /coded_by="NM_001182004.1:1..2064" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:11973290]" /experiment="EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:11842115]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11973290]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:11973290]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:11842115|PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0071007 U2-type catalytic step 2 spliceosome [PMID:11105756]" /experiment="EXISTENCE:direct assay:GO:0071008 U2-type post-mRNA release spliceosomal complex [PMID:11105756]" /experiment="EXISTENCE:mutant phenotype:GO:0000354 cis assembly of pre-catalytic spliceosome [PMID:10445879|PMID:12509417]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:11973290]" /experiment="EXISTENCE:physical interaction:GO:0000354 cis assembly of pre-catalytic spliceosome [PMID:10445879]" /experiment="EXISTENCE:physical interaction:GO:0006270 DNA replication initiation [PMID:11973290]" /note="Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins" /db_xref="GeneID:850808" /db_xref="SGD:S000004107" ORIGIN 1 mdtleptavd thvsaeqilr dvykkgqkar gstnidildl eelreyqrrk rteyegylkr 61 nrldmgqwir yaqfeieqhd mrrarsifer allvdssfip lwiryidael kvkcinharn 121 lmnraistlp rvdklwykyl iveeslnnve ivrslytkwc slepgvnawn sfvdfeirqk 181 nwngvreiys kyvmahpqmq twlkwvrfen rhgnteftrs vyslaidtva nlqnlqiwsd 241 mevaklvnsf ahweaaqqey erssalyqia iekwpsnqll kaglldfekq fgdinsieet 301 isykrkmeye tilsnnaydy dtwwlyldli sesfpkqimq tfekaivdsr pkelsknvqw 361 kryiylwmry icyvelelen slleeelfqr liddiiphkh ftfskiwlmy akflirhddv 421 pkarkilgka iglcpkaktf kgyielevkl kefdrvrkiy ekfiefqpsd lqiwsqygel 481 eenlgdwdrv rgiytialde nsdfltkeak ivllqkyitf etesqefeka rklyrrylel 541 nqyspqswie famyqtstpt eqqlldlakl qsenvdedie feitdenkle arkvfeeaiv 601 ffkekddkqg rlsilealkd yeetygteld qetvkkrfpk vikkvrlqng veeefvdyif 661 pddidddkpk pskflelakk wkqeqal // LOCUS NP_013219 227 aa linear PLN 30-JUN-2025 DEFINITION palmitoyl-(protein) hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013219 VERSION NP_013219.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182005.1 REFERENCE 1 (residues 1 to 227) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 227) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 227) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 227) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09432. Method: conceptual translation. FEATURES Location/Qualifiers source 1..227 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..227 /product="palmitoyl-(protein) hydrolase" /EC_number="3.1.2.22" /calculated_mol_wt="24569" Region 1..225 /region_name="Abhydrolase_2" /note="Phospholipase/Carboxylesterase; pfam02230" /db_xref="CDD:396693" Site 117..121 /site_type="active" /note="nucleophilic elbow [active]" /db_xref="CDD:238287" CDS 1..227 /gene="TML25" /locus_tag="YLR118C" /gene_synonym="APT1" /coded_by="NM_001182005.1:1..684" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008474 palmitoyl-(protein) hydrolase activity [PMID:12080046]" /experiment="EXISTENCE:direct assay:GO:0035601 protein deacylation [PMID:12080046]" /experiment="EXISTENCE:mutant phenotype:GO:0008474 palmitoyl-(protein) hydrolase activity [PMID:12080046]" /experiment="EXISTENCE:mutant phenotype:GO:0035601 protein deacylation [PMID:12080046]" /note="Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:850809" /db_xref="SGD:S000004108" ORIGIN 1 mnglrvaaki qparqtiifl hglgdtgsgw gflaqylqqr dpaafqhtnf vfpnapelhv 61 tanggalmpa wfdilewdps fskvdsdgfm nslnsiektv kqeidkgikp eqiiiggfsq 121 gaalalatsv tlpwkiggiv alsgfcsipg ilkqhkngin vktpifhghg dmdpvvpigl 181 gikakqfyqd sceiqnyefk vykgmahstv pdeledlasf ikkslss // LOCUS NP_013220 213 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-I subunit protein SRN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013220 VERSION NP_013220.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182006.1 REFERENCE 1 (residues 1 to 213) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 213) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 213) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 213) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09433. Method: conceptual translation. FEATURES Location/Qualifiers source 1..213 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..213 /product="ESCRT-I subunit protein SRN2" /calculated_mol_wt="24970" Region 57..202 /region_name="Mod_r" /note="Modifier of rudimentary (Mod(r)) protein; pfam07200" /db_xref="CDD:462117" CDS 1..213 /gene="SRN2" /locus_tag="YLR119W" /gene_synonym="SRN10; VPL16; VPS37" /coded_by="NM_001182006.1:1..642" /experiment="EXISTENCE:direct assay:GO:0000813 ESCRT I complex [PMID:15044434]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:11511343]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:11511343]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:11511343]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0000813 ESCRT I complex [PMID:11511343|PMID:16615894]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15086794|PMID:11511343]" /note="Component of the ESCRT-I complex; ESCRT-I is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus" /db_xref="GeneID:850810" /db_xref="SGD:S000004109" ORIGIN 1 mkvkatklri kqrrknkgln isrldiirae mdvvpspglp ekvnekskni plpeginlls 61 skeiidliqt hrhqlelyvt kfnpltdfag kihafrdqfk qleenfedlh eqkdkvqall 121 encrilesky vaswqdyhse fskkygdial kkkleqntkk ldeessqlet ttrsidsadd 181 ldqfiknyld irtqyhlrre klatwdkqgn lky // LOCUS NP_013221 569 aa linear PLN 30-JUN-2025 DEFINITION aspartyl protease [Saccharomyces cerevisiae S288C]. ACCESSION NP_013221 VERSION NP_013221.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182007.1 REFERENCE 1 (residues 1 to 569) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 569) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 569) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 569) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09434. Method: conceptual translation. FEATURES Location/Qualifiers source 1..569 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..569 /product="aspartyl protease" /EC_number="3.4.23.41" /calculated_mol_wt="59879" Region 81..477 /region_name="SAP_like" /note="SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins; cd05474" /db_xref="CDD:133141" Site order(82,207,210,215,221,256,443,450) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:133141" Site order(101..104,371..374) /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:133141" Site order(101,371) /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:133141" Site order(208..213,215..219) /site_type="active" /note="Active site flap [active]" /db_xref="CDD:133141" CDS 1..569 /gene="YPS1" /locus_tag="YLR120C" /gene_synonym="YAP3" /coded_by="NM_001182007.1:1..1710" /experiment="EXISTENCE:direct assay:GO:0004190 aspartic-type endopeptidase activity [PMID:8626758|PMID:8389368]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:7657670]" /experiment="EXISTENCE:genetic interaction:GO:0016485 protein processing [PMID:18591427]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:16087741]" /experiment="EXISTENCE:genetic interaction:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:2183521]" /experiment="EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:18591427]" /experiment="EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:18591427]" /note="Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor" /db_xref="GeneID:850811" /db_xref="SGD:S000004110" ORIGIN 1 mklktvrsav lsslfasqvl gkiipaankr dddsnskfvk lpfhklygds lenvgsdkkp 61 evrllkradg yeeiiitnqq sfysvdlevg tppqnvtvlv dtgssdlwim gsdnpycssn 121 smgssrrrvi dkrddsssgg slindinpfg wltgtgsaig ptatglgggs gtatqsvpas 181 eatmdcqqyg tfstsgsstf rsnntyfsis ygdgtfasgt fgtdvldlsd lnvtglsfav 241 anetnstmgv lgiglpelev tysgstashs gkaykydnfp ivlknsgaik sntyslylnd 301 sdamhgtilf gavdhskytg tlytipivnt lsasgfsspi qfdvtingig isdsgssnkt 361 ltttkipall dsgttltylp qtvvsmiate lgaqyssrig yyvldcpsdd smeivfdfgg 421 fhinaplssf ilstgttcll giiptsddtg tilgdsfltn ayvvydlenl eismaqaryn 481 ttsenieiit ssvpsavkap gytntwstsa sivtggnift vnssqtasfs gnlttstasa 541 tstsskrnvg dhivpslplt lisllfafi // LOCUS NP_013222 508 aa linear PLN 30-JUN-2025 DEFINITION aspartyl protease [Saccharomyces cerevisiae S288C]. ACCESSION NP_013222 VERSION NP_013222.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182008.1 REFERENCE 1 (residues 1 to 508) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 508) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 508) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 508) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09435. Method: conceptual translation. FEATURES Location/Qualifiers source 1..508 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..508 /product="aspartyl protease" /calculated_mol_wt="54439" Region 61..396 /region_name="SAP_like" /note="SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins; cd05474" /db_xref="CDD:133141" Site order(62,125,128,133,139,174,362,369) /site_type="active" /note="inhibitor binding site [active]" /db_xref="CDD:133141" Site order(81..84,288..291) /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:133141" Site order(81,288) /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:133141" Site order(126..131,133..137) /site_type="active" /note="Active site flap [active]" /db_xref="CDD:133141" CDS 1..508 /gene="YPS3" /locus_tag="YLR121C" /gene_synonym="YPS4" /coded_by="NM_001182008.1:1..1527" /experiment="EXISTENCE:direct assay:GO:0004190 aspartic-type endopeptidase activity [PMID:10191273]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11016834]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:16087741]" /note="Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor" /db_xref="GeneID:850812" /db_xref="SGD:S000004111" ORIGIN 1 mklqlaavat lavltspafg rvlpdgkyvk ipftkkkngd ngelskrsng hekfvlaneq 61 sfysvelaig tpsqnltvll dtgsadlwvp gkgnpycgsv mdcdqygvfd ktksstfkan 121 ksspfyaayg dgtyaegafg qdklkyneld lsglsfavan esnstfgvlg iglstlevty 181 sgkvaimdkr syeydnfplf lkhsgaidat ayslflndes qssgsilfga vdhskyegql 241 ytiplvnlyk sqgyqhpvaf dvtlqglglq tdkrnitltt tklpalldsg ttltylpsqa 301 vallakslna sysktlgyye ytcpssdnkt svafdfggfr inaplsdftm qtsvgtcvla 361 iipqagnata ilgdsflrna yvvydldnye islaqakygt gkenveviks tvpsairaps 421 ynntwsnyas atsggniftt vrtfngtsta tttrstttkk tnstttakst hkskralqra 481 atnsassirs tlglllvpsl lilsvffs // LOCUS NP_001335796 125 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR122C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335796 VERSION NP_001335796.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348856.1 REFERENCE 1 (residues 1 to 125) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 125) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 125) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 125) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80316. Method: conceptual translation. FEATURES Location/Qualifiers source 1..125 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..125 /product="uncharacterized protein" /calculated_mol_wt="14232" CDS 1..125 /locus_tag="YLR122C" /coded_by="NM_001348856.1:1..378" /note="hypothetical protein; conserved among S. cerevisiae strains; partially overlaps dubious ORF YLR123C" /db_xref="GeneID:850813" /db_xref="SGD:S000004112" ORIGIN 1 mnrlyqncmf lyvytdvcvr lcasifyiml eakfalripa lrpsytwgqw rsfiqssfyg 61 rtfvafsgps mknyiticfl lksievsvdr talhgtsaea sasnfqriqt knlskyncni 121 paccv // LOCUS NP_013226 136 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR125W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013226 VERSION NP_013226.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182012.1 REFERENCE 1 (residues 1 to 136) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 136) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 136) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 136) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09436. Method: conceptual translation. FEATURES Location/Qualifiers source 1..136 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..136 /product="uncharacterized protein" /calculated_mol_wt="15067" Region <96..>127 /region_name="RSF" /note="Respiratory growth transcriptional regulator; pfam14876" /db_xref="CDD:464354" CDS 1..136 /locus_tag="YLR125W" /coded_by="NM_001182012.1:1..411" /note="hypothetical protein; mutant has decreased Ty3 transposition; YLR125W is not an essential gene" /db_xref="GeneID:850816" /db_xref="SGD:S000004115" ORIGIN 1 mgeileltnk nfmshlkkdi tsqeslksri edkngdvasp kednypllne taawpdgvit 61 seegcsssge kensglcsee sseedpeeae eesarafgel vavlrdkdip lnvldepqmk 121 dwlekytgvy rsswhg // LOCUS NP_013227 251 aa linear PLN 30-JUN-2025 DEFINITION putative amidotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013227 VERSION NP_013227.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182013.1 REFERENCE 1 (residues 1 to 251) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 251) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 251) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 251) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09437. Method: conceptual translation. FEATURES Location/Qualifiers source 1..251 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..251 /product="putative amidotransferase" /calculated_mol_wt="28695" Region 5..200 /region_name="GATase1_1" /note="Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; cd01741" /db_xref="CDD:153212" Site order(112,198,200) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:153212" CDS 1..251 /locus_tag="YLR126C" /coded_by="NM_001182013.1:1..756" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /note="Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:850817" /db_xref="SGD:S000004116" ORIGIN 1 mtvkkiaily tdednewskp wgnfvdmaik lleqtrklec iaedveyevf hvqknvfpql 61 sdlqkdeylg iyitgskyds fdneiewimk lrsflnemlt skteyppvag icfghqviaa 121 algssvgrnp kgfeggvvsl klnsvgqklf gaqelnlsev hsdcvfdvpe gyqnwassek 181 cqnqgfyrqn rvltfqghpe fnsdvaqkgl lksqdkltle efnryerqcq eldnngiqaa 241 rniwrlflqk i // LOCUS NP_013228 853 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013228 VERSION NP_013228.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182014.1 REFERENCE 1 (residues 1 to 853) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 853) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 853) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 853) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 853) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09438. Method: conceptual translation. FEATURES Location/Qualifiers source 1..853 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..853 /product="anaphase promoting complex subunit 2" /calculated_mol_wt="99847" Region <628..732 /region_name="Cullin" /note="Cullin family; pfam00888" /db_xref="CDD:459983" Region 784..845 /region_name="APC2" /note="Anaphase promoting complex (APC) subunit 2; smart01013" /db_xref="CDD:198081" CDS 1..853 /gene="APC2" /locus_tag="YLR127C" /gene_synonym="RSI1; TID2" /coded_by="NM_001182014.1:1..2562" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:genetic interaction:GO:0007091 metaphase/anaphase transition of mitotic cell cycle [PMID:9430641]" /experiment="EXISTENCE:genetic interaction:GO:0010458 exit from mitosis [PMID:9430641]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473|PMID:9430641]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:1903473 positive regulation of mitotic actomyosin contractile ring contraction [PMID:19109423]" /note="Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p" /db_xref="GeneID:850818" /db_xref="SGD:S000004117" ORIGIN 1 msfqitptrd lkvitdelqt lssyifhtni vddlnslltw mspndaksnh qlrppslrik 61 niikvlfpnn attspysmin tsqannsivn egntnkelql qlfstlkefy ifqvryhffl 121 hfnninylkd iqrwenyyef plryvpifdv nvndwaleln slrhyllnrn ikfknnlrtr 181 ldklimdddf dladnliqwl ksangslsst elivnalysk inkfcednms rvwnkrfmim 241 etfnkfinqy wsqfsklvgc peddhelttt vfncfesnfl rirtneifdi cvlaypdskv 301 tllelrkimk dfkdytnivt tflsdfkkyi lnpsvttvda llryvktika flvldptgrc 361 lhsittfvkp yfqerkhlvn vllyamldlp eeelkekinf nvdmkallsl vdtlhdsdin 421 qdtnitkrdk nkkspflwnl kvkgkrelnk dlpirhamly ehilnyyiaw vpepndmipg 481 nikssyiktn lfevlldlfe sreffisefr nlltdrlftl kfytldekwt rclklireki 541 vkftetshsn yitngilgll ettapaadad qsnlnsidvm lwdikcseel crkmhevagl 601 dpiifpkfis llywkyncdt qgsndlafhl pidlerelqk ysdiysqlkp grklqlckdk 661 gkveiqlafk dgrklvldvs leqcsvinqf dspndepicl sleqlsesln iapprlthll 721 dfwiqkgvll kengtysvie hsemdfdqaq ktapmeiens nyelhndsei erkyeltlqr 781 slpfiegmlt nlgamklhki hsflkitvpk dwgynritlq qlegylntla degrlkyian 841 gsyeivkngh kns // LOCUS NP_013229 269 aa linear PLN 30-JUN-2025 DEFINITION NEDD8 ligase DCN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013229 VERSION NP_013229.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182015.1 REFERENCE 1 (residues 1 to 269) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 269) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 269) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 269) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 269) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09439. Method: conceptual translation. FEATURES Location/Qualifiers source 1..269 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..269 /product="NEDD8 ligase DCN1" /calculated_mol_wt="32072" Region 16..51 /region_name="UBA_DCN1" /note="UBA-like domain found in yeast defective in cullin neddylation protein 1 (DCN1) and similar proteins; cd14352" /db_xref="CDD:270537" Region 144..264 /region_name="Cullin_binding" /note="Cullin binding; pfam03556" /db_xref="CDD:460971" CDS 1..269 /gene="DCN1" /locus_tag="YLR128W" /coded_by="NM_001182015.1:1..810" /experiment="EXISTENCE:direct assay:GO:0031624 ubiquitin conjugating enzyme binding [PMID:18206966]" /experiment="EXISTENCE:direct assay:GO:0032182 ubiquitin-like protein binding [PMID:15988528]" /experiment="EXISTENCE:direct assay:GO:0045116 protein neddylation [PMID:18206966|PMID:15988528]" /experiment="EXISTENCE:genetic interaction:GO:0045116 protein neddylation [PMID:15988528]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:18206966]" /experiment="EXISTENCE:mutant phenotype:GO:0045116 protein neddylation [PMID:15988528|PMID:18206966]" /experiment="EXISTENCE:mutant phenotype:GO:0097602 cullin family protein binding [PMID:18206966]" /note="Scaffold-type E3 ligase; required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation" /db_xref="GeneID:850819" /db_xref="SGD:S000004118" ORIGIN 1 msnnkikrkd aspeqeaies ftsltkcdpk vsrkylqrnh wninyalndy ydkeigtftd 61 evstvahppv ypkeltqvfe hyinnnlfdi dslvkfieel gynledlatl clahllgykk 121 leeplkredf lstwfmqgcs tisdmqecik tldvklhedl qyftqiynya fnlildpnrk 181 didtdegiqy wklffqpeyp vrmepdllea wfrflrdegk ttiskdtwrm lllffkrypt 241 iqkiisdyde taawpfiide fyeclqdqq // LOCUS NP_013230 943 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-binding rRNA-processing protein DIP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013230 VERSION NP_013230.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182016.1 REFERENCE 1 (residues 1 to 943) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 943) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 943) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 943) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 943) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 943) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 943) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 943) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 943) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09440. Method: conceptual translation. FEATURES Location/Qualifiers source 1..943 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..943 /product="snoRNA-binding rRNA-processing protein DIP2" /calculated_mol_wt="106212" Region <36..501 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 83..118 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 124..160 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 168..201 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 207..229 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 256..284 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 332..382 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 383..685 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(390,408,411,417..418,431..432,447,451,457..458, 471..472,489,494,500..501,523,547,552,558..559,571..572, 590,594,600..601,613..614,631,636,642..643,655..656,674, 678,684..685) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 396..430 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 434..470 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 476..521 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 535..570 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 577..613 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 618..654 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 660..684 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 801..910 /region_name="Utp12" /note="Dip2/Utp12 Family; pfam04003" /db_xref="CDD:461125" CDS 1..943 /gene="DIP2" /locus_tag="YLR129W" /gene_synonym="UTP12" /coded_by="NM_001182016.1:1..2832" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034388 Pwp2p-containing subcomplex of 90S preribosome [PMID:17515605|PMID:15231838]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /note="Nucleolar protein; specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex" /db_xref="GeneID:850820" /db_xref="SGD:S000004119" ORIGIN 1 mvksyqrfeq aaafgviasn ancvwipass gnsngsgpgq litsaledvn iwdiktgdlv 61 sklsdglppg asdargakpa ectyleahkd tdllavgyad gvikvwdlms ktvllnfngh 121 kaaitllqfd gtgtrlisgs kdsniivwdl vgevglyklr shkdsitgfw cqgedwlist 181 skdgmiklwd lkthqcieth iahtgecwgl avkddllitt gtdsqvkiwk ldiendkmgg 241 kltemgifek qskqrglkie fitnssdkts ffyiqnadkt ietfrirkee eiarglkkre 301 krlkekglte eeiaksikes yssfilhpfq tirslykiks aswttvsssk lelvlttssn 361 tieyysipye krdptspapl kthtielqgq rtdvrsidis ddnkllatas ngslkiwnik 421 thkcirtfec gyaltckflp ggllvilgtr ngelqlfdla ssslldtied ahdaaiwsld 481 ltsdgkrlvt gsadktvkfw dfkvenslvp gtknkflpvl klhhdttlel tddilcvrvs 541 pddrylaisl ldntvkvffl dsmkfylsly ghklpvlsid isfdskmiit ssadknikiw 601 gldfgdchks lfahqdsimn vkflpqshnf fscskdavvk ywdgekfeci qklyahqsev 661 walavatdgg fvvssshdhs iriweetedq vfleeekeke leeqyedtll tsleegngdd 721 afkadasgeg vedeasgvhk qtleslkage rlmealdlgi aeiegleayn rdmklwqrkk 781 lgeapikpqg navliavnkt peqyimdtll rirmsqleda lmvmpfsyvl kflkfidtvm 841 qnktllhshl plicknlffi ikfnhkelvs qkneelklqi nrvktelrsa lksteddlgf 901 nvqglkfvkq qwnlrhnyef vdeydqqeke snsarkrvfg tvi // LOCUS NP_013231 422 aa linear PLN 30-JUN-2025 DEFINITION low-affinity Zn(2+) transporter ZRT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013231 VERSION NP_013231.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182017.1 REFERENCE 1 (residues 1 to 422) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 422) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 422) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 422) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09441. Method: conceptual translation. FEATURES Location/Qualifiers source 1..422 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..422 /product="low-affinity Zn(2+) transporter ZRT2" /calculated_mol_wt="46232" Region 24..419 /region_name="Zip" /note="ZIP Zinc transporter; pfam02535" /db_xref="CDD:396884" CDS 1..422 /gene="ZRT2" /locus_tag="YLR130C" /coded_by="NM_001182017.1:1..1269" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000007 low-affinity zinc ion transmembrane transporter activity [PMID:8798516]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:8798516]" /experiment="EXISTENCE:mutant phenotype:GO:0071578 zinc ion import across plasma membrane [PMID:8798516]" /note="Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor" /db_xref="GeneID:850821" /db_xref="SGD:S000004120" ORIGIN 1 mvdliardds vdtcqasngy nghaglrila vfiilissgl gvyfpilssr ysfirlpnwc 61 ffiakffgsg vivatafvhl lqpaaealgd eclggtfaey pwafgiclms lfllffteii 121 thyfvaktlg hdhgdhgevt sidvdapssg fvirnmdsdp vsfnneaays ihndktpytt 181 rneeivatpi kekepgsnvt nydlepgkte slanelvpts shatnlasvp gkdhyshend 241 hqdvsqlatr ieeedkeqyl nqilavfile fgiifhsvfv glslsvagee fetlfivltf 301 hqmfeglglg trvaetnwpe skkympwlmg laftltspia vavgigvrhs wipgsrrali 361 angvfdsiss giliytglve lmaheflysn qfkgpdglkk mlsaylimcc gaalmallgk 421 wa // LOCUS NP_013232 770 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcription factor ACE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013232 VERSION NP_013232.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182018.1 REFERENCE 1 (residues 1 to 770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 770) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09442. Method: conceptual translation. FEATURES Location/Qualifiers source 1..770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..770 /product="DNA-binding transcription factor ACE2" /calculated_mol_wt="86503" Region 176..683 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 605..627 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(612,614,616,618..619,622..623,626,642,644,648..649, 652..653,656,668,670,672,674..675,678..679) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 635..657 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 664..680 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..770 /gene="ACE2" /locus_tag="YLR131C" /coded_by="NM_001182018.1:1..2313" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:8657150]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15200949|PMID:22842922|PMID:1730413]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15200949|PMID:1730413]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10409653|PMID:1730413]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8657150]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10409653|PMID:1730413]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:0060196 positive regulation of antisense RNA transcription [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:2001043 positive regulation of septum digestion after cytokinesis [PMID:11259593]" /note="Transcription factor required for septum destruction after cytokinesis; part of the RAM network that regulates polarity and morphogenesis; NES phosphorylation by RAM network kinase Cbk1p blocks nuclear exit in mother cells during the M/G1 transition, causing asymmetric localization to daughter cell nuclei, and increased Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; Spt16p is required for nuclear exclusion during G1" /db_xref="GeneID:850822" /db_xref="SGD:S000004121" ORIGIN 1 mdnvvdpwyi npsgfakdtq deeyvqhhdn vnptipppdn yilnnenddg ldnllgmdyy 61 niddlltqel rdldiplvps pktgdgssdk knidrtwnlg dennkvshys kksmsshkrg 121 lsgtaifgfl ghnktlsiss lqqsilnmsk dpqpmeline lgnhntvknn nddfdhiren 181 dgensylsqv llkqqeelri alekqkevne klekqlrdnq iqqeklrkvl eeqeevaqkl 241 vsgatnsnsk pgspvilktp amqngrmkdn aiivttnsan ggyqfppptl isprmsntsi 301 ngspsrkyhr qrypnkspes nglnlfssns gylrdsells fspqnynlnl dgltyndhnn 361 tsdknnndkk nstgdnifrl fektspggls ispringnsl rspflvgtdk srddryaagt 421 ftprtqlspi hkkresvvst vstisqlqdd tepihmrntq nptlrnanal asssvlppip 481 gssnntpikn slpqkhvfqh tpvkappkng snlapllnap dltdhqleik tpirnnshce 541 vesypqvppv thdihksptl hstsplpdei iprttpmkit kkpttlppgt idqyvkelpd 601 klfeclypnc nkvfkrryni rshiqthlqd rpyscdfpgc tkafvrnhdl irhkishnak 661 kyicpcgkrf nredalmvhr srmictggkk lehsinkklt spkkslldsp hdtspvketi 721 ardkdgsvlm kmeeqlrddm rkhglldppp staaheqnsn rtlsnetdal // LOCUS NP_013233 290 aa linear PLN 30-JUN-2025 DEFINITION phosphoric diester hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013233 VERSION NP_013233.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182019.1 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09443. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..290 /product="phosphoric diester hydrolase" /calculated_mol_wt="33563" Region 45..278 /region_name="HVSL" /note="Uncharacterized conserved protein; pfam09749" /db_xref="CDD:462880" CDS 1..290 /gene="USB1" /locus_tag="YLR132C" /coded_by="NM_001182019.1:1..873" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:22027258|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14690591|PMID:14562095|PMID:22027258]" /experiment="EXISTENCE:genetic interaction:GO:0034477 U6 snRNA 3'-end processing [PMID:22899009]" /experiment="EXISTENCE:mutant phenotype:GO:0034477 U6 snRNA 3'-end processing [PMID:22899009]" /note="Putative poly(U)-specific 3'-to-5' RNA exonuclease; involved in 3'-end processing of U6 snRNA removing uridines and generating a terminal 2',3' cyclic phosphate; essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants; homolog of S.pombe gene, mpn1 and human gene, hUSB1; mutations in hUSB1 are associated with a rare genodermatosis, poikiloderma with neutropenia (OMIM 604173)" /db_xref="GeneID:850823" /db_xref="SGD:S000004122" ORIGIN 1 mefisadyss sdgsdteses snksevqiey tektciqkad stdlpaipds iilkyhippn 61 lqkyehqdmn msrfwrsfty fewrptpaih rqlqkiicky ketfmkqeyt npyqlvdfdp 121 lfishlgapk plhvsltrsl lfeteeqrhv fiqemrnglr nneitpfklq icsypklyis 181 erantlylgl pvsecpnkaq ispfktiiae alqksgisny qdlivsrqnl hvsiaiasnp 241 skatlkryqq lnetmgalll lnndfaykle flvnsiycde nrhsiripfn // LOCUS NP_013234 582 aa linear PLN 30-JUN-2025 DEFINITION bifunctional choline kinase/ethanolamine kinase CKI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013234 VERSION NP_013234.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182020.1 REFERENCE 1 (residues 1 to 582) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 582) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 582) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 582) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 582) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09444. Method: conceptual translation. FEATURES Location/Qualifiers source 1..582 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..582 /product="bifunctional choline kinase/ethanolamine kinase CKI1" /EC_number="2.7.1.32" /calculated_mol_wt="66186" Region 94..144 /region_name="Choline_kin_N" /note="Choline kinase N terminus; pfam04428" /db_xref="CDD:367938" Region 148..556 /region_name="ETNK_euk" /note="Euykaryotic Ethanolamine kinase; cd05157" /db_xref="CDD:270706" Site order(154,156,158..159,161,173,175,204,216..219,222..224, 330,332,334..335,337,393..394,397,413,418) /site_type="active" /note="putative active site [active]" /db_xref="CDD:270706" Site order(154,159,161,173,175,204,216..219,222..224,334,337, 393..394) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270706" Site order(156,158,330,332,335,397,413,418) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:270706" Site order(292..295,298..299,305,309,473,543..544,547,550..551, 554..556) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:270706" CDS 1..582 /gene="CKI1" /locus_tag="YLR133W" /coded_by="NM_001182020.1:1..1749" /experiment="EXISTENCE:direct assay:GO:0004103 choline kinase activity [PMID:2536698]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004103 choline kinase activity [PMID:10329685]" /experiment="EXISTENCE:genetic interaction:GO:0004305 ethanolamine kinase activity [PMID:10329685]" /experiment="EXISTENCE:genetic interaction:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:10329685]" /experiment="EXISTENCE:genetic interaction:GO:0006656 phosphatidylcholine biosynthetic process [PMID:10329685]" /experiment="EXISTENCE:mutant phenotype:GO:0004103 choline kinase activity [PMID:10329685]" /experiment="EXISTENCE:mutant phenotype:GO:0004305 ethanolamine kinase activity [PMID:10329685]" /experiment="EXISTENCE:mutant phenotype:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:10329685]" /experiment="EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:10329685]" /note="Choline kinase; catalyzes the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; CKI1 has a paralog, EKI1, that arose from the whole genome duplication" /db_xref="GeneID:850824" /db_xref="SGD:S000004123" ORIGIN 1 mvqesrpgsv rsysvgyqar srsssqrrhs ltrqrssqrl irtisiesdv snitddddlr 61 avnegvagvq ldvsetankg prrasatdvt dslgstssey ieipfvketl daslpsdylk 121 qdilnliqsl kiskwynnkk iqpvaqdmnl vkisgamtna ifkveypklp slllriygpn 181 idniidreye lqilarlslk nigpslygcf vngrfeqfle nsktltkddi rnwknsqria 241 rrmkelhvgv pllsserkng sacwqkinqw lrtiekvdqw vgdpkniens llcenwskfm 301 divdryhkwl isqeqgieqv nknlifchnd aqygnllfta pvmntpslyt apsstsltsq 361 ssslfpsssn vivddiinpp kqeqsqdskl vvidfeyaga npaaydlanh lsewmydynn 421 akaphqchad rypdkeqvln flysyvshlr ggakepidee vqrlyksiiq wrptvqlfws 481 lwailqsgkl ekkeastait reeigpngkk yiiktepesp eedfvendde peagvsidtf 541 dymaygrdki avfwgdligl giiteeeckn fssfkfldts yl // LOCUS NP_013235 563 aa linear PLN 30-JUN-2025 DEFINITION indolepyruvate decarboxylase 5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013235 VERSION NP_013235.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182021.1 REFERENCE 1 (residues 1 to 563) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 563) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 563) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 563) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09445. Method: conceptual translation. FEATURES Location/Qualifiers source 1..563 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..563 /product="indolepyruvate decarboxylase 5" /EC_number="4.1.1.43" /EC_number="4.1.1.72" /EC_number="4.1.1.74" /calculated_mol_wt="61781" Region 1..551 /region_name="PDC1" /note="TPP-dependent 2-oxoacid decarboxylase, includes indolepyruvate decarboxylase [Carbohydrate transport and metabolism, Coenzyme transport and metabolism, General function prediction only]; COG3961" /db_xref="CDD:443161" CDS 1..563 /gene="PDC5" /locus_tag="YLR134W" /coded_by="NM_001182021.1:1..1692" /experiment="EXISTENCE:direct assay:GO:0004737 pyruvate decarboxylase activity [PMID:2185016|PMID:23423327]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16850348|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019655 glycolytic fermentation to ethanol [PMID:2185016]" /experiment="EXISTENCE:genetic interaction:GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0004737 pyruvate decarboxylase activity [PMID:2185016]" /experiment="EXISTENCE:genetic interaction:GO:0006559 L-phenylalanine catabolic process [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0006569 L-tryptophan catabolic process [PMID:12499363]" /experiment="EXISTENCE:genetic interaction:GO:0019655 glycolytic fermentation to ethanol [PMID:2185016]" /experiment="EXISTENCE:mutant phenotype:GO:0047433 branched-chain-2-oxoacid decarboxylase activity [PMID:9546164]" /note="Minor isoform of pyruvate decarboxylase; key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism" /db_xref="GeneID:850825" /db_xref="SGD:S000004124" ORIGIN 1 mseitlgkyl ferlsqvncn tvfglpgdfn lslldklyev kgmrwagnan elnaayaadg 61 yarikgmsci ittfgvgels alngiagsya ehvgvlhvvg vpsissqakq lllhhtlgng 121 dftvfhrmsa nisettamit dianapaeid rcirttyttq rpvylglpan lvdlnvpakl 181 letpidlslk pndaeaeaev vrtvvelikd aknpvilada casrhdvkae tkklmdltqf 241 pvyvtpmgkg aideqhpryg gvyvgtlsrp evkkavesad lilsigalls dfntgsfsys 301 yktknivefh sdhikirnat fpgvqmkfal qklldaipev vkdykpvavp arvpitkstp 361 antpmkqewm wnhlgnflre gdiviaetgt safginqttf ptdvyaivqv lwgsigftvg 421 allgatmaae eldpkkrvil figdgslqlt vqeistmirw glkpyifvln nngytiekli 481 hgphaeynei qgwdhlallp tfgarnyeth rvattgewek ltqdkdfqdn skirmievml 541 pvfdapqnlv kqaqltaatn akq // LOCUS NP_013236 748 aa linear PLN 30-JUN-2025 DEFINITION Slx4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013236 VERSION NP_013236.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182022.1 REFERENCE 1 (residues 1 to 748) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 748) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 748) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 748) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09446. Method: conceptual translation. FEATURES Location/Qualifiers source 1..748 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..748 /product="Slx4p" /calculated_mol_wt="84231" Region 535..587 /region_name="SLX4_RIM2" /note="second RIM (Rtt107 interaction motif) of Saccharomyces cerevisiae structure-specific endonuclease subunit SLX4 and similar proteins; cd22869" /db_xref="CDD:439372" Site order(536..542,546,548..551,554..572,574,580,584..586) /site_type="other" /note="RTT107 binding site [polypeptide binding]" /db_xref="CDD:439372" Region 585..>692 /region_name="PLN02698" /note="Probable pectinesterase/pectinesterase inhibitor" /db_xref="CDD:178301" Region 685..745 /region_name="Slx4" /note="Slx4 endonuclease; pfam09494" /db_xref="CDD:430644" CDS 1..748 /gene="SLX4" /locus_tag="YLR135W" /coded_by="NM_001182022.1:1..2247" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0017108 5'-flap endonuclease activity [PMID:12832395]" /experiment="EXISTENCE:genetic interaction:GO:0000727 double-strand break repair via break-induced replication [PMID:23071463]" /experiment="EXISTENCE:genetic interaction:GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends [PMID:18471978]" /experiment="EXISTENCE:genetic interaction:GO:0006261 DNA-templated DNA replication [PMID:12832395]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:11139495]" /experiment="EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]" /experiment="EXISTENCE:mutant phenotype:GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends [PMID:18471978]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:12228808]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:12228808]" /experiment="EXISTENCE:mutant phenotype:GO:1903775 regulation of DNA double-strand break processing [PMID:26490958]" /experiment="EXISTENCE:mutant phenotype:GO:1905261 regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination [PMID:27172214]" /experiment="EXISTENCE:mutant phenotype:GO:2000001 regulation of DNA damage checkpoint [PMID:26490958]" /experiment="EXISTENCE:physical interaction:GO:0033557 Slx1-Slx4 complex [PMID:12832395]" /note="Endonuclease involved in processing DNA; acts during recombination, repair; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); cleaves branched structures in complex with Slx1p; involved in interstrand cross-link repair, Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress; FANCP-related factor" /db_xref="GeneID:850826" /db_xref="SGD:S000004125" ORIGIN 1 melqraqrnl kflqnedyvn vtdqtnlnge sqnayslgme tqvpemqfsl ssdddsigtq 61 vksvtaqksp mtqettkndt ernkdvdksc npvstshpdl ggsnieenif intqiqsrld 121 daeeetnlkl klekfkysfk ssnaddthsn anvtakrrpa irkansklkt kpktkrdpki 181 iknitdfnin nyersrtasl lkqlsgkhkk vldiiktqne gnsdkpprar nnkgekatfd 241 tyseqewkdi mklllqkfpq seetdlnevq kflygsekss nsldnqessq qrlwtasqlp 301 pelpdeaiqp eqeerirdtq savnflslsq vmddkseimk deesiiisrg dstssqeygn 361 glepqqpvgn vvgedielav gtrinafslt dykackpmsv evsrrcenst dndydnisiv 421 sdttdetstl fpldqyryvf ienderppla tdtigstqff tpntspldgi idltqesfka 481 vrslisplkv ennktgvtsq asnqvqvpat rtptiipqkn ltttlkteee knnigssirv 541 kllqesvvkl npklvkhnfy rveandseee etefddqfci adiqlvdssk istkdstqnp 601 ttsndiidts aassiaspek fceimmsqsm kelrqslktv glkpmrtkve iiqslqtasq 661 ilstanpdnk gehggvanfs kieifdhlte lieafpdfle riytfepipl nelieklfsa 721 epfvsqidem tirewadvqg iclrndkk // LOCUS NP_013237 285 aa linear PLN 30-JUN-2025 DEFINITION Tis11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013237 VERSION NP_013237.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182023.1 REFERENCE 1 (residues 1 to 285) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 285) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 285) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 285) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09447. Method: conceptual translation. FEATURES Location/Qualifiers source 1..285 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..285 /product="Tis11p" /calculated_mol_wt="32183" Region 2..283 /region_name="CTH1" /note="CCCH-type Zn-finger protein [General function prediction only]; COG5063" /db_xref="CDD:227395" CDS 1..285 /gene="TIS11" /locus_tag="YLR136C" /gene_synonym="CTH2" /coded_by="NM_001182023.1:1..858" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:35858543|PMID:15652485]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18923425|PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21135132|PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:35858543]" /experiment="EXISTENCE:direct assay:GO:0015990 electron transport coupled proton transport [PMID:35858543]" /experiment="EXISTENCE:direct assay:GO:0030371 translation repressor activity [PMID:29912874]" /experiment="EXISTENCE:direct assay:GO:1990641 response to iron ion starvation [PMID:29912874]" /experiment="EXISTENCE:direct assay:GO:2000766 negative regulation of cytoplasmic translation [PMID:35858543]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:15652485]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:15652485]" /note="mRNA-binding protein expressed during iron starvation; binds to sequence element in 3'-untranslated regions of specific mRNAs to mediate degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to nucleus increases upon DNA replication stress; represses translation in response to iron limitation, downregulating multiple transcripts required for mitochondrial translation and heme biosynthesis; inhibits iron-dependent ribosome recycling factor Rli1p" /db_xref="GeneID:850827" /db_xref="SGD:S000004126" ORIGIN 1 mwaqlsytrp esqktdltsl fstdqeqnpl ndyqyqinir eleeyynkti lnedniqets 61 seissavsfs ppkntnaiqp gllydpqlmn pflpsahlns tapttfkkkl evqinpdyvp 121 kssqlpltsq nlqqlsqqkp kndasfssek essaqpkvks qvqetpkqly ktelcesftl 181 kgscpygskc qfahglgelk vkkscknfrt kpcvnweklg ycpygrrccf khgddndiav 241 yvkagtycnv sstskqsdek rsngrgsakk knlnvkvkal qrmtw // LOCUS NP_013238 367 aa linear PLN 30-JUN-2025 DEFINITION S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013238 VERSION NP_013238.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182024.1 REFERENCE 1 (residues 1 to 367) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 367) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 367) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 367) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09448. Method: conceptual translation. FEATURES Location/Qualifiers source 1..367 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..367 /product="S-adenosylmethionine-dependent methyltransferase" /calculated_mol_wt="41261" CDS 1..367 /gene="RKM5" /locus_tag="YLR137W" /coded_by="NM_001182024.1:1..1104" /experiment="EXISTENCE:direct assay:GO:0006479 protein methylation [PMID:21460220]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:21460220]" /note="Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species" /db_xref="GeneID:850828" /db_xref="SGD:S000004127" ORIGIN 1 mafklwllde etiyehvfer ytqlegqsgk laqdlgiqdr rggvleitfe psgleggrkk 61 krvrrrnkas sveedqnvav dsyhvsvgqs isslrssrdn gnsttgyvlw sttpffinwl 121 lystsaapfr lgsqvevtcg ssceghklel prlvdltgad rgkrgilelg agisgilpvi 181 lgnfvdtyvs tdqkgilnkl kdnimenlsq ltrkrcisrs lrlelptvep vgdaditaas 241 lpskstlhle vaaldwekin lqdkkthslh pelsligetc ssvyviamdv iyneylidpf 301 lktlkqlkhw lqttynlqfh vlvgihlrsq evttlfleka iieydftvyd ivdqviqesr 361 fnfylit // LOCUS NP_013239 985 aa linear PLN 30-JUN-2025 DEFINITION Nha1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013239 VERSION NP_013239.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182025.1 REFERENCE 1 (residues 1 to 985) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 985) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 985) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 985) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 985) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 985) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 985) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 985) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 985) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09449. Method: conceptual translation. FEATURES Location/Qualifiers source 1..985 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..985 /product="Nha1p" /calculated_mol_wt="109238" Region 2..923 /region_name="c_cpa1" /note="na(+)/h(+) antiporter; TIGR00844" /db_xref="CDD:273295" CDS 1..985 /gene="NHA1" /locus_tag="YLR138W" /coded_by="NM_001182025.1:1..2958" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9802016|PMID:15950597]" /experiment="EXISTENCE:direct assay:GO:0015385 sodium:proton antiporter activity [PMID:15950597]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:19254924]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:16402204]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:9802016]" /experiment="EXISTENCE:mutant phenotype:GO:0030007 intracellular potassium ion homeostasis [PMID:16402204]" /experiment="EXISTENCE:mutant phenotype:GO:0036376 sodium ion export across plasma membrane [PMID:9802016]" /experiment="EXISTENCE:mutant phenotype:GO:0097623 potassium ion export across plasma membrane [PMID:9802016]" /note="Na+/H+ antiporter; involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH" /db_xref="GeneID:850829" /db_xref="SGD:S000004128" ORIGIN 1 maiweqlevs kahvayacvg vfssifslvs lyvkeklyig estvagifgl ivgpvclnwf 61 nplkwgnsds itleitrivl clqifavave lprkymlkhw vsvtmlllpv mtagwliigl 121 fvwilipgln fsasllisac itatdpilaq svvsgkfaqr vpghlrnlls aesgcndgma 181 fpflflsmnl ilhpgngrei vkdwicvtil yeclfgcllg cfigyvgrit irfaekknii 241 dresflafyv vlafmcagfg silgvddllv sfaagatfaw dgwfsqktqe snvstvidll 301 lnyayfiyfg aiipwsqfnn geigtnvwrl iilsivvifl rripavmilr plipdikswr 361 ealfvghfgp igvgaifaai largelestf sdeptplnvv pskeeskhwq liaciwpitc 421 ffivtsiivh gssvaiitlg rhlntitltk tftthttngd ngksswmqrl psldkagrsf 481 slhrmdtqmt lsgdegeaee gggrkglagg edeeglnndq igsvatsgip arpaggmprr 541 rklsrkekrl nrrqklrnkg reifssrskn emydddelnd lgrerlqkek earaatfals 601 tavntqrnee igmggdeeed eytpekeysd nynntpsfes serssslrgr tyvprnrydg 661 eeteseiese demenesers masseerrir kmkeeemkpg tayldgnrmi ienkqgeiln 721 qvdiedrnea rddevsvdst ahssltttmt nlssssggrl kriltptslg kihslvdkgk 781 dknknskyha fkidnlliie nedgdvikry kinphksddd ksknrprnds vvsraltavg 841 lkskansgvp ppvdeekaie gpsrkgpgml kkrtltpapp rgvqdsldle depsseedlg 901 dsynmddsed yddnayeset eferqrrlna lgemtapadq ddeelpplpv eaqtgndgpg 961 taegkkkqks aavksalskt lglnk // LOCUS NP_013240 643 aa linear PLN 30-JUN-2025 DEFINITION Sls1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013240 VERSION NP_013240.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182026.1 REFERENCE 1 (residues 1 to 643) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 643) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 643) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 643) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 643) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09450. Method: conceptual translation. FEATURES Location/Qualifiers source 1..643 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..643 /product="Sls1p" /calculated_mol_wt="73126" Region 146..343 /region_name="SLS" /note="Mitochondrial inner-membrane-bound regulator; pfam14611" /db_xref="CDD:434070" CDS 1..643 /gene="SLS1" /locus_tag="YLR139C" /coded_by="NM_001182026.1:1..1932" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8917313]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:8917313]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:12637560|PMID:15692048]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8917313]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:12637560]" /note="Mitochondrial membrane protein; coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery" /db_xref="GeneID:850830" /db_xref="SGD:S000004129" ORIGIN 1 mwkfnkklar ltyrlysssg pssplhgkkk lpqnlkfvvl nptqsglvkn dqkqprhrps 61 kkrshketgd nnldfgskll vfekqnslds alnsirlkkp tsaslpsley nallqsltss 121 ynryqlrefi sthqpdsssh lthwkkskls qyiiekiwnc qpistpttpt gikstsltfq 181 fdspreifll litqngkilt nfnklgltfi isiqdneltv kgspsllkya eislnkiwsn 241 ithenvrmys lmpskdvinl iqkethtffe ylpdlqmyki salstkkism akvfllnava 301 snpnttqhhh tiaspalkte lypfnntlen ldwlnksqdw arlqsvvpkn ctdlmtpten 361 atpeltdaqv sqfesslskn ipslspsdsi sqslsitlgh slqsasfssi fqplihksfi 421 skllnlpmyk essssavpvp vpldqhlitn ahqsfiqlnf tpvpptsgss sspflqiwfe 481 idefdnivtt smrpllklqe nsvilrtpqc qtdykitsdy iqdllpdfdq tnpdawlseq 541 kglqefllks hwklnkyqnl mkkinislpd nliqqyqltd vlthrvlnlr fptntaqddk 601 yiiqysdisr gflnngsyrq ldfinvnpse tslktfindv lsf // LOCUS NP_013242 363 aa linear PLN 30-JUN-2025 DEFINITION Rrn5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013242 VERSION NP_013242.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182028.1 REFERENCE 1 (residues 1 to 363) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 363) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 363) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 363) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09451. Method: conceptual translation. FEATURES Location/Qualifiers source 1..363 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..363 /product="Rrn5p" /calculated_mol_wt="41590" CDS 1..363 /gene="RRN5" /locus_tag="YLR141W" /coded_by="NM_001182028.1:1..1092" /experiment="EXISTENCE:direct assay:GO:0000500 RNA polymerase I upstream activating factor complex [PMID:8846924]" /experiment="EXISTENCE:direct assay:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:8846924]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22362748]" /experiment="EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8846924]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:20154141]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8846924]" /note="Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p" /db_xref="GeneID:850832" /db_xref="SGD:S000004131" ORIGIN 1 mehqqlrkyv elynkeveef yngaasgrpa efhpskvhvk sihekagtan agveissvgv 61 dwdseekntf fwclsrysih rvdewrsllp rksameilgy yrllrrasas arsrkagddg 121 apiayemsae wvaletklse tvmaitegaa evadeeghce glidyeswkr rwvaiyshsr 181 iaeirplprh alplsrsatq tlercvsryt rtllwctala gmasrsvsar aaesrghksl 241 ptvvtrrqve ralctearsr dlhvlprriv ltlrkweldy pregklfrtk emahlflqsq 301 lsrrdappvh qdenqenqen qenqeqdnta segeseaerd eideadlfrs alhenqllkw 361 lsk // LOCUS NP_013243 476 aa linear PLN 30-JUN-2025 DEFINITION proline dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013243 VERSION NP_013243.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182029.1 REFERENCE 1 (residues 1 to 476) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 476) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 476) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 476) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09452. Method: conceptual translation. FEATURES Location/Qualifiers source 1..476 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..476 /product="proline dehydrogenase" /EC_number="1.5.5.2" /calculated_mol_wt="53141" Region 176..454 /region_name="Pro_dh" /note="Proline dehydrogenase; pfam01619" /db_xref="CDD:426348" CDS 1..476 /gene="PUT1" /locus_tag="YLR142W" /coded_by="NM_001182029.1:1..1431" /experiment="EXISTENCE:direct assay:GO:0004657 proline dehydrogenase activity [PMID:20450881]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:3125423|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0010133 L-proline catabolic process to L-glutamate [PMID:20450881]" /experiment="EXISTENCE:mutant phenotype:GO:0004657 proline dehydrogenase activity [PMID:387737]" /experiment="EXISTENCE:mutant phenotype:GO:0010133 L-proline catabolic process to L-glutamate [PMID:387737]" /note="Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source" /db_xref="GeneID:850833" /db_xref="SGD:S000004132" ORIGIN 1 miaskssllv tksripslcf plikrsyvsk tpthsntaan lmvetpaana ngnsvmappn 61 sinflqtlpk kelfqlgfig iatlnsffln tiiklfpyip ipvikffvss lycggenfke 121 viecgkrlqk rgisnmmlsl tiensegtks lsstpvdqiv ketissvhni llpniigqle 181 skpindiapg yialkpsalv dnphevlynf snpaykaqrd qliencskit keifelnqsl 241 lkkyperkap fmvstidaek ydlqengvye lqrilfqkfn ptsskliscv gtwqlylrds 301 gdhilhelkl aqengyklgl klvrgayihs eknrnqiifg dktgtdenyd riitqvvndl 361 iingedsyfg hlvvashnyq sqmlvtnllk stqdnsyaks nivlgqllgm adnvtydlit 421 nhgakniiky vpwgppletk dyllrrlqen gdavrsdngw plikaiaksi pkrvgl // LOCUS NP_013244 685 aa linear PLN 30-JUN-2025 DEFINITION diphthine--ammonia ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013244 VERSION NP_013244.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182030.1 REFERENCE 1 (residues 1 to 685) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 685) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 685) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 685) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09453. Method: conceptual translation. FEATURES Location/Qualifiers source 1..685 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..685 /product="diphthine--ammonia ligase" /EC_number="6.3.1.14" /calculated_mol_wt="77810" Region 1..264 /region_name="MJ0570_dom" /note="MJ0570-related uncharacterized domain; TIGR00290" /db_xref="CDD:273000" Region 313..417 /region_name="eu_AANH_C_1" /note="A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the first of these...; cd06155" /db_xref="CDD:100012" Site order(313,373,377,396,411) /site_type="active" /note="putative active site [active]" /db_xref="CDD:100012" Site order(314..315,318,320..321,323,325..326,359,361..362,364, 366,377,380,384,393..401,411,413,415) /site_type="other" /note="homotrimer interaction site [polypeptide binding]" /db_xref="CDD:100012" Region 449..571 /region_name="eu_AANH_C_2" /note="A group of hypothetical eukaryotic proteins, characterized by the presence of an adenine nucleotide alpha hydrolase (AANH)-like domain located N-terminal to two distinctly different YjgF-YER057c-UK114-like domains. This CD contains the second of these...; cd06156" /db_xref="CDD:100013" Site order(449..450,453,455,462,464,466..467,505,507..508,510, 512,523,526,549..556,566,568,570) /site_type="other" /note="homotrimer interaction site [polypeptide binding]" /db_xref="CDD:100013" Site order(449,519,523,551,566) /site_type="active" /note="putative active site [active]" /db_xref="CDD:100013" CDS 1..685 /gene="DPH6" /locus_tag="YLR143W" /coded_by="NM_001182030.1:1..2058" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0017178 diphthine-ammonia ligase activity [PMID:23169644]" /experiment="EXISTENCE:direct assay:GO:0017183 protein histidyl modification to diphthamide [PMID:23169644]" /experiment="EXISTENCE:mutant phenotype:GO:0017178 diphthine-ammonia ligase activity [PMID:23169644]" /experiment="EXISTENCE:mutant phenotype:GO:0017183 protein histidyl modification to diphthamide [PMID:23169644|PMID:23468660]" /note="Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene" /db_xref="GeneID:850835" /db_xref="SGD:S000004133" ORIGIN 1 mkfialisgg kdsfynifhc lknnhelial gniypkesee qeldsfmfqt vghdlidyys 61 kcigvplfrr silrntsnnv elnytatqdd eieelfellr tvkdkipdle avsvgailss 121 yqrtrvenvc srlglvvlsy lwqrdqaelm gemclmskdv nnvendtnsg nkfdariikv 181 aaiglnekhl gmslpmmqpv lqklnqlyqv hicgeggefe tmvldapffq hgylelidiv 241 kcsdgevhna rlkvkfqprn lsksfllnql dqlpvpsifg nnwqdltqnl pkqqaktgeq 301 rfenhmsnal pqttinktnd klyisnlqsr ksetvekqse difteladil hsnqiprnhi 361 lsasllirdm snfgkinkiy nefldlskyg plppsracvg skclpedchv qlsvvvdvkn 421 tgkekinknk gglhvqgrsy wapcnigpys qstwlnddan qvsfisgqig lvpqsmeilg 481 tpltdqivla lqhfdtlcet igaqekllmt cyisdesvld sviktwafyc snmnhrsdlw 541 mdksddvekc lvlvkiselp rgavaefggv tckrlivddn dsdkkereen ddvstvfqkl 601 nlniegfhnt tvsafgynrn fitgfvdsre elelilektp ksaqitlyyn pkeiitfhhh 661 igyypveklf dyrgkehrfg lhirs // LOCUS NP_013245 779 aa linear PLN 30-JUN-2025 DEFINITION endo-1,3(4)-beta-glucanase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013245 VERSION NP_013245.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182031.1 REFERENCE 1 (residues 1 to 779) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 779) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 779) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 779) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09454. Method: conceptual translation. FEATURES Location/Qualifiers source 1..779 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..779 /product="endo-1,3(4)-beta-glucanase" /EC_number="3.2.1.39" /calculated_mol_wt="88272" Region 96..409 /region_name="Glyco_hydro_81" /note="Glycosyl hydrolase family 81 N-terminal domain; pfam03639" /db_xref="CDD:427418" Region 420..772 /region_name="Glyco_hydro81C" /note="Glycosyl hydrolase family 81 C-terminal domain; pfam17652" /db_xref="CDD:435946" CDS 1..779 /gene="ACF2" /locus_tag="YLR144C" /gene_synonym="ENG2; PCA1" /coded_by="NM_001182031.1:1..2340" /experiment="EXISTENCE:direct assay:GO:0030036 actin cytoskeleton organization [PMID:9214384]" /experiment="EXISTENCE:direct assay:GO:0042973 glucan endo-1,3-beta-D-glucosidase activity [PMID:17933563]" /experiment="EXISTENCE:genetic interaction:GO:0042973 glucan endo-1,3-beta-D-glucosidase activity [PMID:12455695]" /note="Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850836" /db_xref="SGD:S000004134" ORIGIN 1 mcysrqaipp pvpnrpggtt nrgppplppr anvqppvcss ensskprenr vageslrtps 61 ssnpladsqv nsdnifqspv lsnlkappsv fnkvqhpvpk pniddqsvdp letnkfytnm 121 llddntqpiw thpysiwfsr dpelfglaan htlasqrvfd tttnpprfyf nptniksfvf 181 karefvssnd iklefrdmkh msmcllmsls ssqfiefplv qgmgfvtaiy hdlgfelrsa 241 vgfrsleris vnerygkyni qlennrnwil yltspdysfp qdfqisllds ntiisshkin 301 glicqlsads vpsidmaagc ypvycdlsgq tvdehftnyr fnytvagysq sgttlmyalp 361 hhkaaftpem qereiassld stvkglmtgy ltnsfdmqvq vpqelgfepv alslnkkady 421 sqeklskire aavqevqlsd pqqesnidsm yfsgkilaky awilyvthyi lhdenltkel 481 lskltiamer fisnqqvlpl nydvswkgii ssgsssqdfg nsyyndhhfh ysyhvitaai 541 islvdsdlsg vtnnswlenn rdwveclird ysgvdnddpy fpqfrsfdwf nghswakglf 601 psgdgkdees tsedvnscya iklwglvtgn skltdianlq lgimrnvfqs yflyesnntv 661 qpkefignkv sgilfenkid hatyfgmepq yihmihaipi tsasswvrtp nfvkeeweek 721 mqpiidqvnd gwkgiimlnm alldpkfsyd ffsqpdfnrn fldngqsltw slaysgafs // LOCUS NP_013246 201 aa linear PLN 30-JUN-2025 DEFINITION Rmp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013246 VERSION NP_013246.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182032.1 REFERENCE 1 (residues 1 to 201) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 201) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 201) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 201) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09455. Method: conceptual translation. FEATURES Location/Qualifiers source 1..201 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..201 /product="Rmp1p" /calculated_mol_wt="23488" Region 10..119 /region_name="RMP1_RBD" /note="RNA binding domain of Saccharomyces cerevisiae RNase MRP protein 1 (RMP1) and similar proteins; cd22573" /db_xref="CDD:439340" Site order(23..24,26..27,30,36,39..40,42..43,47,83..84,87..88) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:439340" CDS 1..201 /gene="RMP1" /locus_tag="YLR145W" /coded_by="NM_001182032.1:1..606" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:15637077]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:17881380]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15637077]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]" /note="Ribonuclease MRP complex-specific subunit; ribonuclease (RNase) MRP processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P; structural similarity but limited sequence homology with human RMP64 (NEPRO)" /db_xref="GeneID:850837" /db_xref="SGD:S000004135" ORIGIN 1 mdemdnvirs leqeyrlill lnhrnknqhr aaswygsfne mkrncgqiit lfssrrlqak 61 rlkdvewvkl hrllqralfr qlkrwywqfn gvialgqfvt lgctlvtlla nvralymrlw 121 einetefirc gcliknlprt kaksvvndve elgeiidedi gnnvqenelv itsipkplte 181 nckkkkkrkk knksaidgif g // LOCUS NP_013247 300 aa linear PLN 30-JUN-2025 DEFINITION spermine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013247 VERSION NP_013247.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182033.1 REFERENCE 1 (residues 1 to 300) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 300) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 300) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 300) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09456. Method: conceptual translation. FEATURES Location/Qualifiers source 1..300 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..300 /product="spermine synthase" /EC_number="2.5.1.22" /calculated_mol_wt="33960" Region 14..293 /region_name="speE" /note="spermidine synthase; TIGR00417" /db_xref="CDD:188048" Site order(95..101,119..120,150..152,177) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..300 /gene="SPE4" /locus_tag="YLR146C" /coded_by="NM_001182033.1:1..903" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006597 spermine biosynthetic process [PMID:9573363]" /experiment="EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]" /experiment="EXISTENCE:mutant phenotype:GO:0016768 spermine synthase activity [PMID:9573363]" /note="Spermine synthase; required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid" /db_xref="GeneID:850838" /db_xref="SGD:S000004136" ORIGIN 1 mvnnsqhpyi kdgwfreind ksfpgqaftm tvdsilyear sefqdilifr nkvygtvlvl 61 dgivqctefd efayqemith iamfahsnpk rvliigggdg gvlrevakhs cveditmvei 121 dssvielsrk flptlsngaf dderldlklc dgfkflqdig asdvhkkfdv iitdssdpeg 181 paeaffqery fellkdalnp ngvvimqsse nfwlnlkylh dlkntakkvf pnteycytmv 241 ptytsgqlgl ivcsnnanip lnipqrkise qeqgklkyyn pqihssafvl ptwadkvine // LOCUS NP_001032582 62 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR146W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032582 VERSION NP_001032582.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184685.1 REFERENCE 1 (residues 1 to 62) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 62) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 62) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 62) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09457. Method: conceptual translation. FEATURES Location/Qualifiers source 1..62 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..62 /product="uncharacterized protein" /calculated_mol_wt="6947" CDS 1..62 /locus_tag="YLR146W-A" /coded_by="NM_001184685.1:1..189" /note="hypothetical protein" /db_xref="GeneID:3799977" /db_xref="SGD:S000113566" ORIGIN 1 mdteekkktt asveharmlq neiqqlfaql rdtnsqircd lnefeqikes sttadsttns 61 an // LOCUS NP_013248 101 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SMD3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013248 VERSION NP_013248.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182034.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09458. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..101 /product="mRNA splicing protein SMD3" /calculated_mol_wt="11093" Region 7..76 /region_name="Sm_D3" /note="Sm protein D3; cd01721" /db_xref="CDD:212468" Site order(19..25,27..39,41..45) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212468" Site order(22..25,27,29,35..36,41,43,61..71) /site_type="other" /note="putative hexamer interface [polypeptide binding]" /db_xref="CDD:212468" Site order(27,29,37,40,43,51,59,61..74) /site_type="other" /note="heptamer interface [polypeptide binding]" /db_xref="CDD:212468" Site order(39,41,52,65..67) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:212468" Site 61..72 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212468" CDS 1..101 /gene="SMD3" /locus_tag="YLR147C" /gene_synonym="SLT16" /coded_by="NM_001182034.1:1..306" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284|PMID:11720285]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9012791|PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:physical interaction:GO:0000243 commitment complex [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0003729 mRNA binding [PMID:10072386]" /note="Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3" /db_xref="GeneID:850839" /db_xref="SGD:S000004137" ORIGIN 1 mtmngipvkl lneaqghivs lelttgatyr gklvesedsm nvqlrdviat epqgavthmd 61 qifvrgsqik fivvpdllkn aplfkknssr pmppirgpkr r // LOCUS NP_013249 918 aa linear PLN 30-JUN-2025 DEFINITION tethering complex subunit PEP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013249 VERSION NP_013249.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182035.1 REFERENCE 1 (residues 1 to 918) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 918) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 918) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 918) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 918) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09459. Method: conceptual translation. FEATURES Location/Qualifiers source 1..918 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..918 /product="tethering complex subunit PEP3" /calculated_mol_wt="107268" Region 214..378 /region_name="Pep3_Vps18" /note="Pep3/Vps18/deep orange family; pfam05131" /db_xref="CDD:461557" Region 585..737 /region_name="CLH" /note="Clathrin heavy chain repeat homology; smart00299" /db_xref="CDD:128594" Region 824..899 /region_name="RING-H2_Pep3p-like" /note="RING finger, H2 subclass, found in Saccharomyces cerevisiae vacuolar membrane protein PEP3 (Pep3p) and similar proteins; cd16462" /db_xref="CDD:438125" CDS 1..918 /gene="PEP3" /locus_tag="YLR148W" /gene_synonym="VAM8; VPS18; VPT18" /coded_by="NM_001182035.1:1..2757" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:10944212]" /experiment="EXISTENCE:direct assay:GO:0033263 CORVET complex [PMID:17488625]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:16601699]" /experiment="EXISTENCE:direct assay:GO:0035542 regulation of SNARE complex assembly [PMID:18385512]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:direct assay:GO:0099022 vesicle tethering [PMID:27307091]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:11422941]" /experiment="EXISTENCE:genetic interaction:GO:0045324 late endosome to vacuole transport [PMID:11422941]" /experiment="EXISTENCE:mutant phenotype:GO:0006904 vesicle docking involved in exocytosis [PMID:10978279]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:11030345]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:physical interaction:GO:0030897 HOPS complex [PMID:10944212]" /note="Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis" /db_xref="GeneID:850840" /db_xref="SGD:S000004138" ORIGIN 1 miktrieevq lqfltgntel thlkvsndql ivttqrtiyr inlqdpaivn hfdcplskel 61 etimnvhvsp mgsvilirtn fgrymllkdg eftqlnkikn ldlsslhwin ettflmgikk 121 tpklyrvelt gkdittklwy enkklsggid giaywegsll ltikdnilyw rdvtnmkfpl 181 vlpdeseqfe rlkhhaikkf dsynglfawv tsngivfgdl kekqmekdpa snnfgkflss 241 skvllnfelp dyqndkdhli kdivltafhi lllrkntvtm vsqlnndvvf hetiprhqlt 301 gsntdsnekf lglvrdsvke tfwcfsninv feiiienepn svwnllvrdn kfdkalslkg 361 ltvreiesvk lskamylfht akdfhsaaqt lgsmkdlshf geialnflqi kdyndlnvil 421 ikqldnvpwk stqvvlsswi iwnfmkqlnd ielkinttkp astdednlln wnlnlkeksn 481 eltkfleshl ekldnetvyq imskqnrqne llifaslind mkfllsfwid qgnwyeslki 541 lltinnhdlv ykyslillln speatvstwm kikdldpnkl iptilkfftn wqnnsklitn 601 iseypenysl tylkwcvrev pkmcnpivyn silymmitdp rndmilendi ikfmksnenk 661 ydlnfqlrls lkfkktktsi flltrlnlfe daidlalknn liddckvivn deiliedykl 721 rkrlwlkiak hlllsmkdid ikqlirtiln dsneiltikd llpffneytt ianlkeelik 781 flenhnmkmn eisediinsk nlkveintei skfneiyril epgkscdecg kflqikkfiv 841 fpcghcfhwn ciirvilnsn dynlrqkten flkakskhnl ndleniivek cglcsdinin 901 kidqpiside telakwne // LOCUS NP_013250 730 aa linear PLN 30-JUN-2025 DEFINITION Gid11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013250 VERSION NP_013250.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182036.1 REFERENCE 1 (residues 1 to 730) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 730) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 730) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 730) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09460. Method: conceptual translation. FEATURES Location/Qualifiers source 1..730 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..730 /product="Gid11p" /calculated_mol_wt="82669" Region 270..308 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 349..383 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 392..431 /region_name="DUF2415" /note="Uncharacterized protein domain (DUF2415); pfam10313" /db_xref="CDD:402091" CDS 1..730 /gene="GID11" /locus_tag="YLR149C" /coded_by="NM_001182036.1:1..2193" /note="Substrate receptor of the glucose-induced degradation-deficient (GID) complex that targets gluconeogenic enzymes for proteasomal degradation upon switch from ethanol to glucose as a carbon source; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850841" /db_xref="SGD:S000004139" ORIGIN 1 mtidgtgqsk ealqderlnt gsdkvyqnym mpalelydak vsinhwqlrd cikpgsmnqs 61 klyyiydhsi rvldtdssvl rspvrrhnsi qpsnsgknst ektstkgsrt tgsyisknlh 121 vpseklvefn fkprcfteln gltvcgglig sddkgfpsnw nrlaqdanis lpppsqpini 181 sknisfpins hysnpniwkg ivefynqetd tmmtftlgqf inncvtlydr asmqfdlfac 241 nndghlyqcd vsnrdvtlvk ryadlkfpln naslshdgqt mvvsgdsnkf avynqneltn 301 qfslhydnhp swgssvnrvr riprfalpde seyieniyea pnsdhgfyns fsendlqfat 361 vfqngtcaiy dirnmatpma eisstrphsh ngafrvcrfs yglddllfis ehqgrvhvvd 421 trnyvnhqvi vipdkvnmey inerkhntnh nfttnnnnen esndsknelq gadyrslsrr 481 rfslpsmpnv ttepwitmaq ripkkylepq ilpfpkvmdk isnesvlfst kgssssdvah 541 pykrrcsfrv rrvstsapta dysnnnvnas lgtpaadsia tsssnsapqn lidplilshq 601 qasndvfedd eyyeayndvh styrvssdyh gvsarafesf lrppstpdlp sdddnfaans 661 rnnrgtsnfl rrpvittqes nefseennis gidwvedrng ssliigtdyg imrwninswa 721 rrsfssydlc // LOCUS NP_013251 273 aa linear PLN 30-JUN-2025 DEFINITION Stm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013251 VERSION NP_013251.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182037.1 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09461. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..273 /product="Stm1p" /calculated_mol_wt="29864" Region 3..56 /region_name="Stm1_N" /note="pfam09598" /db_xref="CDD:430706" CDS 1..273 /gene="STM1" /locus_tag="YLR150W" /gene_synonym="MPT4" /coded_by="NM_001182037.1:1..822" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:15654430]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15044472|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:15044472]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:15044472]" /experiment="EXISTENCE:direct assay:GO:0043066 negative regulation of apoptotic process [PMID:11514626]" /experiment="EXISTENCE:direct assay:GO:0045142 triplex DNA binding [PMID:18029617]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:12207228]" /experiment="EXISTENCE:genetic interaction:GO:0006414 translational elongation [PMID:19666721]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:19666721]" /experiment="EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:16580682]" /experiment="EXISTENCE:mutant phenotype:GO:0043558 regulation of translational initiation in response to stress [PMID:16580682]" /note="Ribosome hibernation factor; regulates ribosome homeostasis by coupling ribosome biosynthesis and degradation in response to nutrient availability; has nucleolar role promoting ribosome biogenesis during exponential growth, distinct from cytosolic role during nutrient starvation when it forms dormant 80S ribosomes protecting them from proteasomal degradation; perturbs association of Yef3p with ribosomes; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure" /db_xref="GeneID:850843" /db_xref="SGD:S000004140" ORIGIN 1 msnpfdllgn dvedadvvvl ppkeivksnt sskkadvppp sadpskarkn rprpsgnega 61 irdktagrrn nrskdvtdsa ttkksntrra tdrhsrtgkt dtkkkvnqgw gddkkelsae 121 keaqadaaae iaedaaeaed agkpktaqls lqdylnqqan nqfnkvpeak kveldaerie 181 taekeayvpa tkvknvkskq lktkeylefd atfvesntrk nfgdrnnnsr nnfnnrrggr 241 garkgnntan atnsantvqk nrnidvsnlp sla // LOCUS NP_013252 340 aa linear PLN 30-JUN-2025 DEFINITION 8-oxo-dGTP diphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013252 VERSION NP_013252.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182038.1 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09462. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..340 /product="8-oxo-dGTP diphosphatase" /EC_number="3.6.1.56" /EC_number="3.6.1.77" /calculated_mol_wt="39624" Region 38..211 /region_name="NUDIX_CoAse_Nudt7" /note="coenzyme A pyrophosphatase and similar proteins; cd03426" /db_xref="CDD:467532" CDS 1..340 /gene="PCD1" /locus_tag="YLR151C" /coded_by="NM_001182038.1:1..1023" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:10922370]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [PMID:15475388]" /experiment="EXISTENCE:direct assay:GO:0010945 coenzyme A diphosphatase activity [PMID:10922370]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15475388]" /experiment="EXISTENCE:mutant phenotype:GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity [PMID:15475388]" /note="8-oxo-dGTP diphosphatase; prevents spontaneous mutagenesis via sanitization of oxidized purine nucleoside triphosphates; can also act as peroxisomal pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids; nudix hydrolase family member; similar E. coli MutT and human, rat and mouse MTH1" /db_xref="GeneID:850844" /db_xref="SGD:S000004141" ORIGIN 1 milsqrrmls skqlienlir ykfhktpytr ssiwpfkrns aviillfigm kgelrvlltk 61 rsrtlrsfsg dvsfpggkad yfqetfesva rreaeeeigl phdpevlhke fgmkldnlvm 121 dmpcylsrtf lsvkpmvcfl ykdklekhed kykvpldirk ffgklnpget sslfsvplnd 181 lvihllpead edvksyqaey ferkeyklnw ggikwlimhy hfhvannnem pwlqtiedls 241 ssdedgvdgg ifrfrdlwgl tckilfdvsc ianglmdekl kgelghedli vglhdygnqm 301 qpngrsewei gmingdrnlk ysdvipeyym khllecrslw // LOCUS NP_013253 576 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR152C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013253 VERSION NP_013253.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182039.1 REFERENCE 1 (residues 1 to 576) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 576) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 576) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 576) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09463. Method: conceptual translation. FEATURES Location/Qualifiers source 1..576 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..576 /product="uncharacterized protein" /calculated_mol_wt="63901" Region 11..>194 /region_name="Mem_trans" /note="Membrane transport protein; cl22894" /db_xref="CDD:451441" CDS 1..576 /locus_tag="YLR152C" /coded_by="NM_001182039.1:1..1731" /note="hypothetical protein; YLR152C is not an essential gene" /db_xref="GeneID:850845" /db_xref="SGD:S000004142" ORIGIN 1 mslslgaaiy ialkpifkiy timlvgylva kfdivsmena kgisnmvvna ilpcltfnki 61 vsniswrdik eigviilsaf ilfvlgatga lfttfattvp kkffwglifa gffpnisdlp 121 iayiqsmgng siftaeeadk gvaysciflf iqsflmmnfg mwrvvgldfr dtkepdseni 181 tpsvspaidd rklteitklp nitrptnayq sedarsnsdl scnsittnem tpqafyegft 241 gyikpykesn gashkfesdl phaeiyrvss tysspgalef sridgsslsy srisknsdgr 301 syrrkrkadm neliskysaa ekirqgeldl srplslteev gsrnasignv htgytdessi 361 eeenctnmat dgrgslsffi erhnlkwlqy fiinclrpas lgailgiica lipwvkacfv 421 ttyvhvhkap dgepvlnflm dfteyignac vplgllllgg tlarleiksl ppgfiksall 481 mtcfrlivip iigvlwvnkl ysidwldtgi gkfdmiltws mpsataqvyf tafytpacgd 541 hiqmnclsvl fvmqyailfi tvafvvtytl kvdlkv // LOCUS NP_013254 683 aa linear PLN 30-JUN-2025 DEFINITION acetate--CoA ligase ACS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013254 VERSION NP_013254.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182040.1 REFERENCE 1 (residues 1 to 683) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 683) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 683) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 683) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09464. Method: conceptual translation. FEATURES Location/Qualifiers source 1..683 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..683 /product="acetate--CoA ligase ACS2" /EC_number="6.2.1.1" /calculated_mol_wt="75361" Region 38..662 /region_name="ACS" /note="Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); cd05966" /db_xref="CDD:341270" Site order(178..180,206,209,211,319,324..325,347..349,373..374, 377,400..403,425..430,516,528,531,539..542,612,617..618) /site_type="active" /db_xref="CDD:341270" Site order(178..180,206,209,211,319,325,347..349,373..374,377, 539..541,612,617) /site_type="other" /note="CoA binding site [chemical binding]" /db_xref="CDD:341270" Site order(275,278..283,285..286) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341270" Site order(324..325,400..403,425..430,516,528,531,542) /site_type="other" /note="AMP binding site [chemical binding]" /db_xref="CDD:341270" Site order(324..325,400..401,428) /site_type="other" /note="acetate binding site [chemical binding]" /db_xref="CDD:341270" CDS 1..683 /gene="ACS2" /locus_tag="YLR153C" /coded_by="NM_001182040.1:1..2052" /experiment="EXISTENCE:direct assay:GO:0003987 acetate-CoA ligase activity [PMID:8910545]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16857587|PMID:19618123]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19618123]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16857587|PMID:9711835]" /experiment="EXISTENCE:direct assay:GO:0006085 acetyl-CoA biosynthetic process [PMID:8910545]" /experiment="EXISTENCE:direct assay:GO:0016880 acid-ammonia (or amide) ligase activity [PMID:18305111]" /note="Acetyl-coA synthetase isoform; along with Acs1p, acetyl-coA synthetase isoform is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions" /db_xref="GeneID:850846" /db_xref="SGD:S000004143" ORIGIN 1 mtikehkvvy eahnvkalka pqhfynsqpg kgyvtdmqhy qemyqqsine pekffdkmak 61 eylhwdapyt kvqsgslnng dvawflngkl nasyncvdrh afanpdkpal iyeaddesdn 121 kiitfgellr kvsqiagvlk swgvkkgdtv aiylpmipea viamlavari gaihsvvfag 181 fsagslkdrv vdanskvvit cdegkrggkt intkkivdeg lngvdlvsri lvfqrtgteg 241 ipmkagrdyw wheeaakqrt ylppvscdae dplfllytsg stgspkgvvh ttggyllgaa 301 lttryvfdih pedvlftagd vgwitghtya lygpltlgta siifestpay pdygrywrii 361 qrhkathfyv aptalrlikr vgeaeiakyd tsslrvlgsv gepispdlwe wyhekvgnkn 421 cvicdtmwqt esgshliapl agavptkpgs atvpffgina ciidpvtgve legndvegvl 481 avkspwpsma rsvwnhhdry mdtylkpypg hyftgdgagr dhdgyywirg rvddvvnvsg 541 hrlstseiea sisnhenvse aavvgipdel tgqtvvayvs lkdgylqnna tegdaehitp 601 dnlrrelilq vrgeigpfas pktiilvrdl prtrsgkimr rvlrkvasne aeqlgdlttl 661 anpevvpaii savenqffsq kkk // LOCUS NP_013255 110 aa linear PLN 30-JUN-2025 DEFINITION Rnh203p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013255 VERSION NP_013255.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182041.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09465. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..110 /product="Rnh203p" /calculated_mol_wt="12351" Region 14..90 /region_name="RNase_H2-C" /note="Ribonuclease H2-C is a subunit of the eukaryotic RNase H complex which cleaves RNA-DNA hybrids; cl07291" /db_xref="CDD:415133" Site order(14..18,34,37,39..44,67..70) /site_type="other" /note="heterotrimeric interface" /db_xref="CDD:187752" CDS 1..110 /gene="RNH203" /locus_tag="YLR154C" /coded_by="NM_001182041.1:1..333" /experiment="EXISTENCE:direct assay:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006401 RNA catabolic process [PMID:14734815]" /experiment="EXISTENCE:direct assay:GO:0032299 ribonuclease H2 complex [PMID:14734815]" /experiment="EXISTENCE:genetic interaction:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]" /note="Ribonuclease H2 subunit; required for RNase H2 activity; role in ribonucleotide excision repair; related to human AGS3 that causes Aicardi-Goutieres syndrome" /db_xref="GeneID:850847" /db_xref="SGD:S000004144" ORIGIN 1 mtkdavnlda ytvsfmpfyt eyqgpteefk dykfedtiyf rgkelkreks atpsssdntt 61 sntfsngail sgntitgkiv svnnyeregt drnelarlqe lislidvinq // LOCUS NP_690845 124 aa linear PLN 30-JUN-2025 DEFINITION Tar1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_690845 VERSION NP_690845.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184514.1 REFERENCE 1 (residues 1 to 124) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 124) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 124) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 124) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09466. Method: conceptual translation. FEATURES Location/Qualifiers source 1..124 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..124 /product="Tar1p" /calculated_mol_wt="14214" CDS 1..124 /gene="TAR1" /locus_tag="YLR154W-C" /gene_synonym="YLR154W-A" /coded_by="NM_001184514.1:1..375" /experiment="EXISTENCE:genetic interaction:GO:0043457 regulation of cellular respiration [PMID:18622616]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:12414727]" /note="Protein potentially involved in regulation of respiratory metabolism; located in the mitochondria; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand" /db_xref="GeneID:850849" /db_xref="SGD:S000028422" ORIGIN 1 mrdspthkeq raqntmsdqm pfpfnnftyf ftlfskffss fhhctcslsv srqylaldgi 61 yhplraafpn nstlrrhftk nrtprhtgfs psmtscskeh rqgtapklps pnynsgtegt 121 rfqi // LOCUS NP_878121 49 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR154C-G [Saccharomyces cerevisiae S288C]. ACCESSION NP_878121 VERSION NP_878121.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184560.1 REFERENCE 1 (residues 1 to 49) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 49) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 49) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 49) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09467. Method: conceptual translation. FEATURES Location/Qualifiers source 1..49 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..49 /product="uncharacterized protein" /calculated_mol_wt="5914" CDS 1..49 /locus_tag="YLR154C-G" /coded_by="NM_001184560.1:1..150" /note="hypothetical protein; identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2" /db_xref="GeneID:1466409" /db_xref="SGD:S000028561" ORIGIN 1 mwrrrrepwe elsfllnsls prnwfirrwg lmagrgqhlc wlrcacdgp // LOCUS NP_878126 43 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR154C-H [Saccharomyces cerevisiae S288C]. ACCESSION NP_878126 VERSION NP_878126.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184564.1 REFERENCE 1 (residues 1 to 43) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 43) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 43) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 43) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09477. Method: conceptual translation. FEATURES Location/Qualifiers source 1..43 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..43 /product="uncharacterized protein" /calculated_mol_wt="4576" CDS 1..43 /locus_tag="YLR154C-H" /coded_by="NM_001184564.1:1..132" /note="hypothetical protein; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-2; YLR154C-H has a paralog, YLR157C-C, that arose from a segmental duplication" /db_xref="GeneID:1466410" /db_xref="SGD:S000028562" ORIGIN 1 myscakkktt aapefrvwsp ttllgqalts lttvdrtgng afw // LOCUS NP_013256 362 aa linear PLN 30-JUN-2025 DEFINITION asparaginase ASP3-1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013256 VERSION NP_013256.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182042.1 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09469. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..362 /product="asparaginase ASP3-1" /EC_number="3.5.1.1" /calculated_mol_wt="38556" Region 9..359 /region_name="asnASE_II" /note="L-asparaginase, type II; TIGR00520" /db_xref="CDD:273115" Site order(42..43,88..90,121..123,147,195,284) /site_type="active" /db_xref="CDD:199208" Site order(43,90..94,97,123,127,149,154..156,159..160,184..185, 189,191,195..198,200,210..212,214,216,221,223..225, 227..228,251,253,255,259,261,270,272,280..282,284,286, 308..309,316..317) /site_type="other" /note="homotetramer interface [polypeptide binding]" /db_xref="CDD:199208" Site order(90..94,97,123..124,126..128,195..199,249..251,253, 255,259,261..262,266..267,270,272,280..282,284..286, 308..310,313..314,332..333,336) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:199208" CDS 1..362 /gene="ASP3-1" /locus_tag="YLR155C" /gene_synonym="ASP3" /coded_by="NM_001182042.1:1..1089" /experiment="EXISTENCE:direct assay:GO:0004067 asparaginase activity [PMID:238936]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006530 L-asparagine catabolic process [PMID:3042786]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:3042786]" /experiment="EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:238936]" /note="Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from wine yeast Wickerhamomyces anomalus or close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-1 has paralog ASP3-3 that arose from a segmental duplication" /db_xref="GeneID:850850" /db_xref="SGD:S000004145" ORIGIN 1 mrslntllls lfvamssgap llkireekns slpsikifgt ggtiaskgst sattagysvg 61 ltvndlieav pslaekanld ylqvsnvgsn slnythlipl yhgisealas ddyagavvth 121 gtdtmeetaf fldltinsek pvciagamrp atatsadgpm nlyqavsiaa sekslgrgtm 181 itlndriasg fwttkmnans ldtfradeqg ylgyfsnddv efyyppvkpn gwqffdisnl 241 tdpseipevi ilysyqglnp elivkavkdl gakgivlags gagswtatgs ivneqlyeey 301 gipivhsrrt adgtvppdda peyaigsgyl npqksrillq lclysgygmd qirsvfsgvy 361 gg // LOCUS NP_757337 114 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR156W [Saccharomyces cerevisiae S288C]. ACCESSION NP_757337 VERSION NP_757337.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182043.1 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09470. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..114 /product="uncharacterized protein" /calculated_mol_wt="13007" CDS 1..114 /locus_tag="YLR156W" /coded_by="NM_001182043.1:1..345" /note="hypothetical protein; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis; YLR156W has a paralog, YLR159W, that arose from a segmental duplication" /db_xref="GeneID:850851" /db_xref="SGD:S000004146" ORIGIN 1 mkfqyalake qlgsnsrsgv kkliskhhwl peyyfsdlsf svvqqwdsra iekttiiscm 61 rpanqeiypl rhcetlrsqp cslfsslyar sfqssctlhv aepspgfhmy gcht // LOCUS NP_878123 43 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR156C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878123 VERSION NP_878123.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184563.1 REFERENCE 1 (residues 1 to 43) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 43) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 43) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 43) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09471. Method: conceptual translation. FEATURES Location/Qualifiers source 1..43 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..43 /product="uncharacterized protein" /calculated_mol_wt="4576" CDS 1..43 /locus_tag="YLR156C-A" /coded_by="NM_001184563.1:1..132" /note="hypothetical protein; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-3; YLR156C-A has a paralog, YLR159C-A, that arose from a segmental duplication" /db_xref="GeneID:1466411" /db_xref="SGD:S000028564" ORIGIN 1 myscakkktt aapefrvwsp ttllgqalts lttvdrtgng afw // LOCUS NP_013258 362 aa linear PLN 30-JUN-2025 DEFINITION asparaginase ASP3-2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013258 VERSION NP_013258.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182044.1 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09472. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..362 /product="asparaginase ASP3-2" /EC_number="3.5.1.1" /calculated_mol_wt="38556" Region 9..359 /region_name="asnASE_II" /note="L-asparaginase, type II; TIGR00520" /db_xref="CDD:273115" Site order(42..43,88..90,121..123,147,195,284) /site_type="active" /db_xref="CDD:199208" Site order(43,90..94,97,123,127,149,154..156,159..160,184..185, 189,191,195..198,200,210..212,214,216,221,223..225, 227..228,251,253,255,259,261,270,272,280..282,284,286, 308..309,316..317) /site_type="other" /note="homotetramer interface [polypeptide binding]" /db_xref="CDD:199208" Site order(90..94,97,123..124,126..128,195..199,249..251,253, 255,259,261..262,266..267,270,272,280..282,284..286, 308..310,313..314,332..333,336) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:199208" CDS 1..362 /gene="ASP3-2" /locus_tag="YLR157C" /gene_synonym="ASP3" /coded_by="NM_001182044.1:1..1089" /experiment="EXISTENCE:direct assay:GO:0004067 asparaginase activity [PMID:238936]" /experiment="EXISTENCE:direct assay:GO:0006530 L-asparagine catabolic process [PMID:3042786]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:3042786]" /experiment="EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:238936]" /note="Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-2 has a paralog, ASP3-4, that arose from a segmental duplication" /db_xref="GeneID:850852" /db_xref="SGD:S000004147" ORIGIN 1 mrslntllls lfvamssgap llkireekns slpsikifgt ggtiaskgst sattagysvg 61 ltvndlieav pslaekanld ylqvsnvgsn slnythlipl yhgisealas ddyagavvth 121 gtdtmeetaf fldltinsek pvciagamrp atatsadgpm nlyqavsiaa sekslgrgtm 181 itlndriasg fwttkmnans ldtfradeqg ylgyfsnddv efyyppvkpn gwqffdisnl 241 tdpseipevi ilysyqglnp elivkavkdl gakgivlags gagswtatgs ivneqlyeey 301 gipivhsrrt adgtvppdda peyaigsgyl npqksrillq lclysgygmd qirsvfsgvy 361 gg // LOCUS NP_878124 70 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR157W-D [Saccharomyces cerevisiae S288C]. ACCESSION NP_878124 VERSION NP_878124.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184608.1 REFERENCE 1 (residues 1 to 70) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 70) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 70) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 70) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09473. Method: conceptual translation. FEATURES Location/Qualifiers source 1..70 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..70 /product="uncharacterized protein" /calculated_mol_wt="8064" CDS 1..70 /locus_tag="YLR157W-D" /gene_synonym="YLR157W-A" /coded_by="NM_001184608.1:1..213" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; YLR157W-D has a paralog, YLR161W, that arose from a segmental duplication" /db_xref="GeneID:1466412" /db_xref="SGD:S000028677" ORIGIN 1 mkfqyalake qlgsnsrsgv kkliskhhwl peyyfsdlsf svvqqwdsra iekttiiscm 61 rpanqeiypl // LOCUS NP_058169 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058169 VERSION NP_058169.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184406.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09474. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198415" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YLR157C-B" /coded_by="join(NM_001184406.2:1..1305, NM_001184406.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:850853" /db_xref="SGD:S000007374" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanapti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp nsapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd eyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_058170 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058170 VERSION NP_058170.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184405.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09475. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..440 /product="gag protein" /calculated_mol_wt="48822" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YLR157C-A" /coded_by="NM_001184405.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:850854" /db_xref="SGD:S000007373" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_878125 54 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR157W-E [Saccharomyces cerevisiae S288C]. ACCESSION NP_878125 VERSION NP_878125.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184609.1 REFERENCE 1 (residues 1 to 54) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 54) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 54) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 54) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 54) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09476. Method: conceptual translation. FEATURES Location/Qualifiers source 1..54 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..54 /product="uncharacterized protein" /calculated_mol_wt="6014" CDS 1..54 /locus_tag="YLR157W-E" /gene_synonym="YLR157W-B; YLR157W-C" /coded_by="NM_001184609.1:1..165" /note="hypothetical protein identified by gene-trapping; microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element" /db_xref="GeneID:1466413" /db_xref="SGD:S000028678" ORIGIN 1 mivdfysntl rhcetlrsqp cslfsslyar sfqssctlhv aepspgfhmy gcht // LOCUS NP_878122 43 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR157C-C [Saccharomyces cerevisiae S288C]. ACCESSION NP_878122 VERSION NP_878122.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184561.1 REFERENCE 1 (residues 1 to 43) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 43) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 43) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 43) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09468. Method: conceptual translation. FEATURES Location/Qualifiers source 1..43 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..43 /product="uncharacterized protein" /calculated_mol_wt="4576" CDS 1..43 /locus_tag="YLR157C-C" /coded_by="NM_001184561.1:1..132" /note="hypothetical protein; identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RDN5-4; YLR157C-C has a paralog, YLR154C-H, that arose from a segmental duplication" /db_xref="GeneID:1466414" /db_xref="SGD:S000028565" ORIGIN 1 myscakkktt aapefrvwsp ttllgqalts lttvdrtgng afw // LOCUS NP_013259 362 aa linear PLN 30-JUN-2025 DEFINITION asparaginase ASP3-3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013259 VERSION NP_013259.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182045.1 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09478. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..362 /product="asparaginase ASP3-3" /EC_number="3.5.1.1" /calculated_mol_wt="38556" Region 9..359 /region_name="asnASE_II" /note="L-asparaginase, type II; TIGR00520" /db_xref="CDD:273115" Site order(42..43,88..90,121..123,147,195,284) /site_type="active" /db_xref="CDD:199208" Site order(43,90..94,97,123,127,149,154..156,159..160,184..185, 189,191,195..198,200,210..212,214,216,221,223..225, 227..228,251,253,255,259,261,270,272,280..282,284,286, 308..309,316..317) /site_type="other" /note="homotetramer interface [polypeptide binding]" /db_xref="CDD:199208" Site order(90..94,97,123..124,126..128,195..199,249..251,253, 255,259,261..262,266..267,270,272,280..282,284..286, 308..310,313..314,332..333,336) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:199208" CDS 1..362 /gene="ASP3-3" /locus_tag="YLR158C" /gene_synonym="ASP3" /coded_by="NM_001182045.1:1..1089" /experiment="EXISTENCE:direct assay:GO:0004067 asparaginase activity [PMID:238936]" /experiment="EXISTENCE:direct assay:GO:0006530 L-asparagine catabolic process [PMID:3042786]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:3042786]" /experiment="EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:238936]" /note="Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-3 has a paralog, ASP3-1, that arose from a segmental duplication" /db_xref="GeneID:850855" /db_xref="SGD:S000004148" ORIGIN 1 mrslntllls lfvamssgap llkireekns slpsikifgt ggtiaskgst sattagysvg 61 ltvndlieav pslaekanld ylqvsnvgsn slnythlipl yhgisealas ddyagavvth 121 gtdtmeetaf fldltinsek pvciagamrp atatsadgpm nlyqavsiaa sekslgrgtm 181 itlndriasg fwttkmnans ldtfradeqg ylgyfsnddv efyyppvkpn gwqffdisnl 241 tdpseipevi ilysyqglnp elivkavkdl gakgivlags gagswtatgs ivneqlyeey 301 gipivhsrrt adgtvppdda peyaigsgyl npqksrillq lclysgygmd qirsvfsgvy 361 gg // LOCUS NP_757338 114 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR159W [Saccharomyces cerevisiae S288C]. ACCESSION NP_757338 VERSION NP_757338.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182046.1 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09479. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..114 /product="uncharacterized protein" /calculated_mol_wt="13007" CDS 1..114 /locus_tag="YLR159W" /coded_by="NM_001182046.1:1..345" /note="hypothetical protein; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR159W has a paralog, YLR156W, that arose from a segmental duplication" /db_xref="GeneID:850856" /db_xref="SGD:S000004149" ORIGIN 1 mkfqyalake qlgsnsrsgv kkliskhhwl peyyfsdlsf svvqqwdsra iekttiiscm 61 rpanqeiypl rhcetlrsqp cslfsslyar sfqssctlhv aepspgfhmy gcht // LOCUS NP_878127 43 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR159C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878127 VERSION NP_878127.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184565.1 REFERENCE 1 (residues 1 to 43) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 43) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 43) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 43) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 43) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09480. Method: conceptual translation. FEATURES Location/Qualifiers source 1..43 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..43 /product="uncharacterized protein" /calculated_mol_wt="4576" CDS 1..43 /locus_tag="YLR159C-A" /coded_by="NM_001184565.1:1..132" /note="hypothetical protein; identified by fungal homology comparisons and RT-PCR; partially overlaps RND5-5; YLR159C-A has a paralog, YLR156C-A, that arose from a segmental duplication" /db_xref="GeneID:1466415" /db_xref="SGD:S000028566" ORIGIN 1 myscakkktt aapefrvwsp ttllgqalts lttvdrtgng afw // LOCUS NP_013261 362 aa linear PLN 30-JUN-2025 DEFINITION asparaginase ASP3-4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013261 VERSION NP_013261.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182047.1 REFERENCE 1 (residues 1 to 362) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 362) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 362) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 362) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 362) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09481. Method: conceptual translation. FEATURES Location/Qualifiers source 1..362 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..362 /product="asparaginase ASP3-4" /EC_number="3.5.1.1" /calculated_mol_wt="38556" Region 9..359 /region_name="asnASE_II" /note="L-asparaginase, type II; TIGR00520" /db_xref="CDD:273115" Site order(42..43,88..90,121..123,147,195,284) /site_type="active" /db_xref="CDD:199208" Site order(43,90..94,97,123,127,149,154..156,159..160,184..185, 189,191,195..198,200,210..212,214,216,221,223..225, 227..228,251,253,255,259,261,270,272,280..282,284,286, 308..309,316..317) /site_type="other" /note="homotetramer interface [polypeptide binding]" /db_xref="CDD:199208" Site order(90..94,97,123..124,126..128,195..199,249..251,253, 255,259,261..262,266..267,270,272,280..282,284..286, 308..310,313..314,332..333,336) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:199208" CDS 1..362 /gene="ASP3-4" /locus_tag="YLR160C" /gene_synonym="ASP3" /coded_by="NM_001182047.1:1..1089" /experiment="EXISTENCE:direct assay:GO:0004067 asparaginase activity [PMID:238936]" /experiment="EXISTENCE:direct assay:GO:0006530 L-asparagine catabolic process [PMID:3042786]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:3042786]" /experiment="EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:238936]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; likely arose in via horizontal gene transfer from the wine yeast Wickerhamomyces anomalus or a close relative; enzyme preparation shows antitumor activity; reference strain S288C has four copies of ASP3; ASP3-4 has a paralog, ASP3-2, that arose from a segmental duplication" /db_xref="GeneID:850857" /db_xref="SGD:S000004150" ORIGIN 1 mrslntllls lfvamssgap llkireekns slpsikifgt ggtiaskgst sattagysvg 61 ltvndlieav pslaekanld ylqvsnvgsn slnythlipl yhgisealas ddyagavvth 121 gtdtmeetaf fldltinsek pvciagamrp atatsadgpm nlyqavsiaa sekslgrgtm 181 itlndriasg fwttkmnans ldtfradeqg ylgyfsnddv efyyppvkpn gwqffdisnl 241 tdpseipevi ilysyqglnp elivkavkdl gakgivlags gagswtatgs ivneqlyeey 301 gipivhsrrt adgtvppdda peyaigsgyl npqksrillq lclysgygmd qirsvfsgvy 361 gg // LOCUS NP_757339 114 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR161W [Saccharomyces cerevisiae S288C]. ACCESSION NP_757339 VERSION NP_757339.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182048.1 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09482. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..114 /product="uncharacterized protein" /calculated_mol_wt="13007" CDS 1..114 /locus_tag="YLR161W" /coded_by="NM_001182048.1:1..345" /note="hypothetical protein; YLR156W, YLR159W, and YLR161W are three identical open reading frames in S288C encoded near the ribosomal DNA region of chromosome 12; YLR161W has a paralog, YLR157W-D, that arose from a segmental duplication" /db_xref="GeneID:850858" /db_xref="SGD:S000004151" ORIGIN 1 mkfqyalake qlgsnsrsgv kkliskhhwl peyyfsdlsf svvqqwdsra iekttiiscm 61 rpanqeiypl rhcetlrsqp cslfsslyar sfqssctlhv aepspgfhmy gcht // LOCUS NP_013263 118 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR162W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013263 VERSION NP_013263.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182049.1 REFERENCE 1 (residues 1 to 118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 118) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09483. Method: conceptual translation. FEATURES Location/Qualifiers source 1..118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..118 /product="uncharacterized protein" /calculated_mol_wt="12924" CDS 1..118 /locus_tag="YLR162W" /coded_by="NM_001182049.1:1..357" /note="hypothetical protein; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride" /db_xref="GeneID:850859" /db_xref="SGD:S000004152" ORIGIN 1 mqhtltrtas lpersssahs aatalpalrr ppdscetlvp llcifwfvfv smsplppara 61 nksdnkglis adrnnkatll ltiprctsks ytndlsplkm tllsagkhpr pfrqehrc // LOCUS NP_878128 62 aa linear PLN 30-JUN-2025 DEFINITION Rrt15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878128 VERSION NP_878128.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184566.1 REFERENCE 1 (residues 1 to 62) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 62) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 62) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 62) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09484. Method: conceptual translation. FEATURES Location/Qualifiers source 1..62 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..62 /product="Rrt15p" /calculated_mol_wt="7149" CDS 1..62 /gene="RRT15" /locus_tag="YLR162W-A" /coded_by="NM_001184566.1:1..189" /note="hypothetical protein; identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription" /db_xref="GeneID:1466416" /db_xref="SGD:S000028567" ORIGIN 1 mvcihtenqn qgdfypfvll eisvlhespl ghlryrltdv ppqpnspgei ycfyincimn 61 rr // LOCUS NP_013264 462 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial processing peptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013264 VERSION NP_013264.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182050.1 REFERENCE 1 (residues 1 to 462) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 462) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 462) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 462) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09485. Method: conceptual translation. FEATURES Location/Qualifiers source 1..462 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..462 /product="mitochondrial processing peptidase" /EC_number="3.4.24.64" /calculated_mol_wt="50953" Region 18..451 /region_name="PqqL" /note="Predicted Zn-dependent peptidase, M16 family [General function prediction only]; COG0612" /db_xref="CDD:440377" CDS 1..462 /gene="MAS1" /locus_tag="YLR163C" /gene_synonym="MIF1" /coded_by="NM_001182050.1:1..1389" /experiment="EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:2905264]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006627 protein processing involved in protein targeting to mitochondrion [PMID:2007593]" /experiment="EXISTENCE:direct assay:GO:0017087 mitochondrial processing peptidase complex [PMID:2905264]" /note="Beta subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" /db_xref="GeneID:850860" /db_xref="SGD:S000004153" ORIGIN 1 mfsrtaskfr ntrrllstis sqipgtrtsk lpngltiate yipntssatv gifvdagsra 61 envknngtah flehlafkgt qnrsqqgiel eienigshln aytsrentvy yakslqedip 121 kavdilsdil tksvldnsai ererdviire seevdkmyde vvfdhlheit ykdqplgrti 181 lgpikniksi trtdlkdyit knykgdrmvl agagavdhek lvqyaqkyfg hvpksespvp 241 lgsprgplpv fcrgerfike ntlptthiai alegvswsap dyfvalatqa ivgnwdraig 301 tgtnspspla vaasqngsla nsymsfstsy adsglwgmyi vtdsnehnvq livneilkew 361 kriksgkisd aevnrakaql kaalllsldg staivedigr qvvttgkrls peevfeqvdk 421 itkddiimwa nyrlqnkpvs mvalgntstv pnvsyieekl nq // LOCUS NP_013265 168 aa linear PLN 30-JUN-2025 DEFINITION protein SHH4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013265 VERSION NP_013265.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182051.1 REFERENCE 1 (residues 1 to 168) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 168) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 168) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 168) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09486. Method: conceptual translation. FEATURES Location/Qualifiers source 1..168 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..168 /product="protein SHH4" /calculated_mol_wt="18501" Region 28..159 /region_name="CybS" /note="succinate dehydrogenase cytochrome B small subunit; pfam05328" /db_xref="CDD:461624" CDS 1..168 /gene="SHH4" /locus_tag="YLR164W" /coded_by="NM_001182051.1:1..507" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10637294]" /experiment="EXISTENCE:genetic interaction:GO:0006121 mitochondrial electron transport, succinate to ubiquinone [PMID:25328978]" /experiment="EXISTENCE:genetic interaction:GO:0008177 succinate dehydrogenase (quinone) activity [PMID:25328978]" /experiment="EXISTENCE:genetic interaction:GO:0045273 respiratory chain complex II (succinate dehydrogenase) [PMID:25328978]" /note="Putative alternate subunit of succinate dehydrogenase (SDH); mitochondrial inner membrane protein; genetic interaction with SDH4 suggests that Shh4p can function as a functional SDH subunit; a fraction copurifies with SDH subunit Sdh3p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner; Shh4p has greater similarity to human SDHD (subunit D of SDH, implicated in paraganglioma) than does its paralog Sdh4p" /db_xref="GeneID:850861" /db_xref="SGD:S000004154" ORIGIN 1 msstkflkpl crirafhtsi arsftipflp kipqkpggvs gtandssymp pesraqgsyh 61 wiverglsla vlpliavplv ttgpistftd tflslvllgh chigfqscii dyiservygk 121 vhhyamylls lgsflsfvgi yklesqeagl iaslkslwdn kpvekkrq // LOCUS NP_013266 254 aa linear PLN 30-JUN-2025 DEFINITION pseudouridine synthase PUS5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013266 VERSION NP_013266.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182052.1 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09487. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..254 /product="pseudouridine synthase PUS5" /EC_number="5.4.99.43" /calculated_mol_wt="29228" Region 16..205 /region_name="PseudoU_synth_RluA_like" /note="Pseudouridine synthase, RluA family; cd02869" /db_xref="CDD:211346" Site order(68..71,167) /site_type="active" /db_xref="CDD:211346" CDS 1..254 /gene="PUS5" /locus_tag="YLR165C" /coded_by="NM_001182052.1:1..765" /experiment="EXISTENCE:mutant phenotype:GO:0000154 rRNA modification [PMID:10756195]" /experiment="EXISTENCE:mutant phenotype:GO:0001522 pseudouridine synthesis [PMID:10756195]" /experiment="EXISTENCE:mutant phenotype:GO:0004730 pseudouridylate synthase activity [PMID:10756195]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:10756195]" /note="Pseudouridine synthase; catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability" /db_xref="GeneID:850862" /db_xref="SGD:S000004155" ORIGIN 1 mslkkqipii fenthyfivn kppgipsqpp dcrtwgrthp nldptpller fkaiyyshre 61 velcrtvhrl dhcvtggmli aktkdgsvkf srflqkggnn gyklqrkyva ivessgrfnk 121 pnnyeikygp kynflishgg reitkfkevd encivlqlvt gkkhqirnhv sqilnqpiln 181 dkrhgstvnf pelfndqial hsaciitkig lqtkthlipm ehnntgqlws rkyvneegef 241 tlpikevlle nwdq // LOCUS NP_013267 871 aa linear PLN 30-JUN-2025 DEFINITION exocyst subunit SEC10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013267 VERSION NP_013267.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182053.1 REFERENCE 1 (residues 1 to 871) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 871) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 871) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 871) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 871) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 871) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 871) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 871) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 871) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09488. Method: conceptual translation. FEATURES Location/Qualifiers source 1..871 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..871 /product="exocyst subunit SEC10" /calculated_mol_wt="100211" Region 120..858 /region_name="Sec10" /note="Exocyst complex component Sec10; pfam07393" /db_xref="CDD:399988" CDS 1..871 /gene="SEC10" /locus_tag="YLR166C" /coded_by="NM_001182053.1:1..2616" /experiment="EXISTENCE:direct assay:GO:0000145 exocyst [PMID:8978675]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:6996832]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /note="Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion" /db_xref="GeneID:850863" /db_xref="SGD:S000004156" ORIGIN 1 mnslyeldpk wkkllktdnf lggltvnefv qelskdhrnd vlidantknl ptnekdqdai 61 reaiwkqldp kpyirtfest lkelknlnee tlnkrqyfse qvatqevihs enviklskdl 121 httlltfdkl ddrltnvtqv vsplgdklet aikkkqnyiq svelirrynd fysmgksdiv 181 eqlrlsknwk lnlksvklmk nllilsskle tssipktint klviekysem menellenfn 241 sayrennftk lneiaiilnn fnggvnviqs finqhdyfid tkqidlenef envfiknvkf 301 keqlidfenh sviietsmqn lindvetvik neskivkrvf eekathviql fiqrvfaqki 361 eprfevllrn slsisnlayv rilhglftlf gkftkslidy fqlleiddsn qilsttleqc 421 fadlfshyly drskyfgiek rsleailvdm tskftvnydk einkrvlldk ykeklstnvd 481 afmhsprgnt hsrqdstsrs klsqfnsflk thldkdhlsl nrtntlsdsf nnsssstqyd 541 vannssslvn ssftasdidn spnspanysl ndvdsmlkcv vestarvmel ipnkahlyil 601 eilkimflgi vdsymeiale vaywkickvd inktagvvnl nflkfismst eildllsisi 661 ksiflpllnn speikaqiie mtnsqiqkme iliniilqet itvistkfsa ilckqkkkdf 721 vpksqelldq dtlpaieivn ilnlifeqss kflkgknlqt fltligeely glllshyshf 781 qvnsiggvvv tkdiigyqta iedwgvasli dkfatlrela nlftvqpell esltkeghla 841 digrdiiqsy isnredfnhd nfinsvklnf r // LOCUS NP_013268 152 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-40S ribosomal protein eS31 RPS31 fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013268 VERSION NP_013268.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182054.1 REFERENCE 1 (residues 1 to 152) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 152) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 152) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 152) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09489. Method: conceptual translation. FEATURES Location/Qualifiers source 1..152 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..152 /product="ubiquitin-40S ribosomal protein eS31 RPS31 fusion protein" /calculated_mol_wt="17085" Region 1..76 /region_name="Ubl_ubiquitin" /note="ubiquitin-like (Ubl) domain found in ubiquitin; cd01803" /db_xref="CDD:340501" Site order(6..9,11,34..37,40,42,44,46..49,68..76) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:340501" Site order(8..12,31..35,40,42,44,46..49,68,70..76) /site_type="other" /note="E1 interaction site [polypeptide binding]" /db_xref="CDD:340501" Region 103..146 /region_name="Ribosomal_S27" /note="Ribosomal protein S27a; pfam01599" /db_xref="CDD:460261" CDS 1..152 /gene="RPS31" /locus_tag="YLR167W" /gene_synonym="RPS37; UBI3" /coded_by="NM_001182054.1:1..459" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:385049|PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:18782943|PMID:385049]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:9830035]" /experiment="EXISTENCE:mutant phenotype:GO:0002109 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [PMID:2538753]" /experiment="EXISTENCE:mutant phenotype:GO:0031386 protein tag activity [PMID:2538753]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:32408794]" /note="Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog" /db_xref="GeneID:850864" /db_xref="SGD:S000004157" ORIGIN 1 mqifvktltg ktitlevess dtidnvkski qdkegippdq qrlifagkql edgrtlsdyn 61 iqkestlhlv lrlrgggkkr kkkvyttpkk ikhkhkkvkl avlsyykvda egkvtklrre 121 csnptcgagv flanhkdrly cgkchsvykv na // LOCUS NP_013269 230 aa linear PLN 30-JUN-2025 DEFINITION Ups2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013269 VERSION NP_013269.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182055.1 REFERENCE 1 (residues 1 to 230) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 230) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 230) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 230) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09490. Method: conceptual translation. FEATURES Location/Qualifiers source 1..230 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..230 /product="Ups2p" /calculated_mol_wt="26375" Region 15..172 /region_name="PRELI" /note="PRELI-like family; pfam04707" /db_xref="CDD:398400" CDS 1..230 /gene="UPS2" /locus_tag="YLR168C" /gene_synonym="AIM30; GEP1; MSF1; MSF1'" /coded_by="NM_001182055.1:1..693" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:19506038]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:27354379]" /experiment="EXISTENCE:genetic interaction:GO:0032048 cardiolipin metabolic process [PMID:19506038]" /experiment="EXISTENCE:genetic interaction:GO:0042407 cristae formation [PMID:19221197]" /experiment="EXISTENCE:genetic interaction:GO:0046337 phosphatidylethanolamine metabolic process [PMID:19221197]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:19221197]" /experiment="EXISTENCE:mutant phenotype:GO:0046337 phosphatidylethanolamine metabolic process [PMID:19221197]" /experiment="EXISTENCE:mutant phenotype:GO:2001246 negative regulation of phosphatidylcholine biosynthetic process [PMID:22403410]" /note="Mitochondrial intermembrane space protein; involved in phospholipid metabolism; forms complex with Mdm35p that transfers phosphatidylserine from outer membrane to inner membrane for phosphatidylethanolamine synthesis; null mutant has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI; UPS2 has a paralog, UPS3, that arose from the whole genome duplication" /db_xref="GeneID:850865" /db_xref="SGD:S000004158" ORIGIN 1 mklfqnsydf nypwdqvtaa nwkkypneis thviavdvlr relkdqgkvl vterlitvkq 61 gvpkwimmml ggtnmshvre vsvvdlnkks ltmrscnltm cnllkvyetv tysphpddsa 121 nktlfqqeaq itaygsirkl cnkmedwsvq rfcenakkgk mgfdavlqvf senwekhvdd 181 lsnqlvskvn etmedvkisa gtllkgters grtilqqnid lfrdaynhen // LOCUS NP_013271 156 aa linear PLN 30-JUN-2025 DEFINITION Aps1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013271 VERSION NP_013271.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182057.1 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09491. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..156 /product="Aps1p" /calculated_mol_wt="18021" Region 5..149 /region_name="AP1_sigma" /note="AP-1 complex subunit sigma; cd14831" /db_xref="CDD:341435" Site order(11..12,17,64..67,91..92,95,100..104) /site_type="other" /note="dileucine motif interface [polypeptide binding]" /db_xref="CDD:341435" Site order(16..19,21..22,47..51,78..82,84..86,89,100,107..110, 114..115,118..119,122..123,125..130,132..134,141..143, 145..146,149) /site_type="other" /note="AP-1 gamma interface [polypeptide binding]" /db_xref="CDD:341435" Site order(28,32,36,39,53..56) /site_type="other" /note="AP-1 mu interface [polypeptide binding]" /db_xref="CDD:341435" CDS 1..156 /gene="APS1" /locus_tag="YLR170C" /gene_synonym="YAP19" /coded_by="NM_001182057.1:1..471" /experiment="EXISTENCE:direct assay:GO:0030121 AP-1 adaptor complex [PMID:10564262]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:17003107]" /note="Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex" /db_xref="GeneID:850868" /db_xref="SGD:S000004160" ORIGIN 1 mtqlkylllv srqgkirlkk wytamsagek akivkdltpt ilarkpkmcn iieyndhkvv 61 ykryaslyfi vgmtpdvdne lltleiihrf vetmdtyfgn vceldiifnf skvydilnem 121 imcdgsiaes srkevlhhvt vmdtmesndn lervls // LOCUS NP_013273 300 aa linear PLN 30-JUN-2025 DEFINITION diphthine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013273 VERSION NP_013273.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182059.1 REFERENCE 1 (residues 1 to 300) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 300) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 300) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 300) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09492. Method: conceptual translation. FEATURES Location/Qualifiers source 1..300 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..300 /product="diphthine synthase" /EC_number="2.1.1.314" /calculated_mol_wt="33716" Region 1..257 /region_name="PTZ00175" /note="diphthine synthase; Provisional" /db_xref="CDD:185500" Site order(9,35,84..85,88..90,113..114,163..164,219,221..222, 246..248) /site_type="other" /note="SAM binding site [chemical binding]" /db_xref="CDD:381174" Site order(9,65,83..85,88..90,113..114,118,133,162..163, 219..222,246..248) /site_type="active" /note="putative active site [active]" /db_xref="CDD:381174" Site order(9,11,13..18,20..21,85,87..88,90,93..94,96..97, 100..101,107..113,115..117,119..120,122,124..126,128..131, 152..153,155,158,223,226) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:381174" CDS 1..300 /gene="DPH5" /locus_tag="YLR172C" /coded_by="NM_001182059.1:1..903" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0017183 protein histidyl modification to diphthamide [PMID:3042777]" /experiment="EXISTENCE:direct assay:GO:0141133 diphthine methyl ester synthase activity [PMID:3042777]" /experiment="EXISTENCE:mutant phenotype:GO:0017183 protein histidyl modification to diphthamide [PMID:1508200]" /experiment="EXISTENCE:mutant phenotype:GO:0141133 diphthine methyl ester synthase activity [PMID:1508200]" /note="Methyltransferase required for synthesis of diphthamide; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm" /db_xref="GeneID:850869" /db_xref="SGD:S000004162" ORIGIN 1 mlyliglgls yksditvrgl eaikkcsrvy lehytsilma asqeelesyy gkeiiladre 61 lvetgskqil nnadkedvaf lvvgdpfgat thtdlvlrak reaipveiih nasvmnavga 121 cglqlynfgq tvsmvfftdn wrpdswydki wenrkiglht lvlldikvke qsienmargr 181 liyeppryms iaqcceqlle ieekrgtkay tpdtpavais rlgsssqsfk sgtiselany 241 dsgeplhslv ilgrqchele leyllefadd kekfgkdvan dqeyfkpaaw vppteddsde // LOCUS NP_013274 608 aa linear PLN 30-JUN-2025 DEFINITION Tag1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013274 VERSION NP_013274.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182060.1 REFERENCE 1 (residues 1 to 608) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 608) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 608) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 608) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09493. Method: conceptual translation. FEATURES Location/Qualifiers source 1..608 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..608 /product="Tag1p" /calculated_mol_wt="69475" CDS 1..608 /gene="TAG1" /locus_tag="YLR173W" /coded_by="NM_001182060.1:1..1827" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:33536246|PMID:19001347|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:33536246]" /experiment="EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:33536246]" /experiment="EXISTENCE:mutant phenotype:GO:0018105 peptidyl-serine phosphorylation [PMID:33536246]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:33536246]" /note="Vacuolar membrane protein involved in termination of autophagy; regulates autophagy termination during persistent nitrogen starvation through Atg1p-mediated re-phosphorylation of Atg13p and PAS disassembly; type II membrane protein containing hydrophobic transmembrane region with N-terminal region oriented toward cytosol and C-terminus inside lumen; luminal domain is glycosylated; forms foci in vacuole membrane during starvation; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:850870" /db_xref="SGD:S000004163" ORIGIN 1 mhtnsplrad nqdletqpll rpnteesqll ndevrinvan etliksrwrs ikcliiyllg 61 ivllsffgvs ivqyirghvp ptdvieknlv qvtnfklvef qldgwkdnmg sdlnndtgky 121 lqvsihsqiw fdydkwpgte ndsdarsqrd wiryinekvl kticidlnnv ttfdgdlvfk 181 nklgdvvgme picfnlahrq innlqfkilv kpsiwkivkv lkkfwnrdfe slniksnldm 241 tifkrkfgtr fnllklndei ldwkdiidwe kisatplrmi qnmidgislq gftlrdsssd 301 gfhadmrlnp itilggvdwl hlppgtsipf inweiklpdc ngepaiaipt lscfnepinl 361 hhdkdnivvc lqneiegplp dellyqecpq nsltpmsqiv navlnqnetv tfaarghvle 421 dgidnnslip admledifqe asfipittna tfnsseliqe fqindlqlrw aarkklslvg 481 tflgffdlsf yethqqdrvr idtirgqidl yhndinflnl pmkqwinsss hilhdedtgn 541 tqmklqfdle nddmevvnsl eltrtlneil fqgftvihfn atidasltta lgpwvltgla 601 gegdtlvt // LOCUS NP_013275 412 aa linear PLN 30-JUN-2025 DEFINITION isocitrate dehydrogenase (NADP(+)) IDP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013275 VERSION NP_013275.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182061.1 REFERENCE 1 (residues 1 to 412) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 412) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 412) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 412) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09494. Method: conceptual translation. FEATURES Location/Qualifiers source 1..412 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..412 /product="isocitrate dehydrogenase (NADP(+)) IDP2" /EC_number="1.1.1.42" /calculated_mol_wt="46431" Region 2..409 /region_name="nadp_idh_euk" /note="isocitrate dehydrogenase, NADP-dependent, eukaryotic type; TIGR00127" /db_xref="CDD:129233" CDS 1..412 /gene="IDP2" /locus_tag="YLR174W" /coded_by="NM_001182061.1:1..1239" /experiment="EXISTENCE:direct assay:GO:0004450 isocitrate dehydrogenase (NADP+) activity [PMID:15574419]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15001388|PMID:19854152]" /experiment="EXISTENCE:genetic interaction:GO:0006102 isocitrate metabolic process [PMID:15574419]" /experiment="EXISTENCE:mutant phenotype:GO:0006102 isocitrate metabolic process [PMID:15574419]" /note="Cytosolic NADP-specific isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose; IDP2 has a paralog, IDP3, that arose from the whole genome duplication; mutation in human homolog IDH1 is associated with low-grade gliomas and secondary glioblastomas" /db_xref="GeneID:850871" /db_xref="SGD:S000004164" ORIGIN 1 mtkikvanpi vemdgdeqtr iiwhlirdkl vlpyldvdlk yydlsveyrd qtndqvtvds 61 atatlkygva vkcatitpde arveefhlkk mwkspngtir nilggtvfre piiipriprl 121 vpqwekpiii grhafgdqyk atdvivpeeg elrlvyksks gthdvdlkvf dypehggvam 181 mmynttdsie gfakasfela ierklplyst tkntilkkyd gkfkdvfeam yarsykekfe 241 slgiwyehrl iddmvaqmlk skggyiiamk nydgdvesdi vaqgfgslgl mtsvlitpdg 301 ktfeseaahg tvtrhfrqhq qgketstnsi asifawtrgi iqrgkldntp dvvkfgqile 361 satvntvqed gimtkdlali lgksersayv tteefidave srlkkefeaa al // LOCUS NP_013276 483 aa linear PLN 30-JUN-2025 DEFINITION pseudouridine synthase CBF5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013276 VERSION NP_013276.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182062.1 REFERENCE 1 (residues 1 to 483) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 483) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 483) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 483) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09495. Method: conceptual translation. FEATURES Location/Qualifiers source 1..483 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..483 /product="pseudouridine synthase CBF5" /calculated_mol_wt="54574" Region 26..351 /region_name="CBF5" /note="rRNA pseudouridine synthase, putative; TIGR00425" /db_xref="CDD:273073" CDS 1..483 /gene="CBF5" /locus_tag="YLR175W" /coded_by="NM_001182062.1:1..1452" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:15962000]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]" /experiment="EXISTENCE:mutant phenotype:GO:0000495 box H/ACA sno(s)RNA 3'-end processing [PMID:15964797]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9472021]" /experiment="EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:9472021]" /experiment="EXISTENCE:mutant phenotype:GO:0031118 rRNA pseudouridine synthesis [PMID:9472021]" /experiment="EXISTENCE:mutant phenotype:GO:0031120 snRNA pseudouridine synthesis [PMID:15962000]" /experiment="EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25219674|PMID:25192136]" /experiment="EXISTENCE:physical interaction:GO:0031429 box H/ACA snoRNP complex [PMID:9472021]" /note="Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs; acts on large and small rRNAs, on snRNA U2, and on some mRNAs; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita; small nucleolar ribonucleoprotein particles are also known as snoRNPs" /db_xref="GeneID:850872" /db_xref="SGD:S000004165" ORIGIN 1 mskedfvikp eaagastdts ewplllknfd kllvrsghyt pipagssplk rdlksyissg 61 vinldkpsnp sshevvawik rilrcektgh sgtldpkvtg clivcidrat rlvksqqgag 121 keyvcivrlh dalkdekdlg rslenltgal fqrpplisav krqlrvrtiy esnliefdnk 181 rnlgvfwasc eagtymrtlc vhlgmllgvg ghmqelrrvr sgalsendnm vtlhdvmdaq 241 wvydntrdes ylrsiiqple tllvgykriv vkdsavnavc ygaklmipgl lryeegiely 301 deivlittkg eaiavaiaqm stvdlascdh gvvasvkrci merdlyprrw glgpvaqkkk 361 qmkadgkldk ygrvnentpe qwkkeyvpld naeqstsssq etketeeepk kakedslike 421 vetekeevke ddskkekkek kdkkekkekk ekkdkkekke kkekkrksed gdseekkskk 481 skk // LOCUS NP_013277 811 aa linear PLN 30-JUN-2025 DEFINITION Rfx1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013277 VERSION NP_013277.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182063.1 REFERENCE 1 (residues 1 to 811) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 811) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 811) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 811) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 811) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09496. Method: conceptual translation. FEATURES Location/Qualifiers source 1..811 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..811 /product="Rfx1p" /calculated_mol_wt="90453" Region 282..358 /region_name="RFX_DNA_binding" /note="RFX DNA-binding domain; pfam02257" /db_xref="CDD:460512" CDS 1..811 /gene="RFX1" /locus_tag="YLR176C" /gene_synonym="CRT1" /coded_by="NM_001182063.1:1..2436" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9741624]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9741624]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16835445]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16835445]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16107689]" /note="Major transcriptional repressor of DNA-damage-regulated genes; recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins" /db_xref="GeneID:850873" /db_xref="SGD:S000004166" ORIGIN 1 mvifkerkpt enlftrkipa kyfifspsfl svhyfefylp msgdnniept srgsndnsng 61 psngssvnsn ryslnapkys sqpppashty lppmsvnipp iasksssiys llhqssprpe 121 tpnpilppli gsgpgshkps ptptqppaqp atqrqpatys vypasislnr snssayplsf 181 kseetlnnnp ptaakrtntf psipsstkkq ktsqekriss isrrntqeii akqiaennks 241 ktieeyaqiv khaeikvlsm dsqntskaal qlaeqnrere rqvfallwlm kncksqhdsy 301 vprgkifaqy asscsqnnlk plsqaslgkl irtvfpdltt rrlgmrgqsk yhycglkltv 361 nesgsvslnn nnaslslvhn ndpisplssp spsspspqvp nvsspfslnr kslsrtgspv 421 kqssndnpne pelesqhpne teankldslp paannptgtl ssdeltfthd liekvfncnd 481 klsdnyntqi lsntehpllt sykldfpkip agvlptdtds dvisslesly hihcnsvyec 541 ikflksdnis nalffsnsns isptmfnlfi seplidwvtk cdlitytgli kffsqfiihs 601 neisdsiiqk lesmikllpe qinkavlelp kalvqrklsi innftklvkk likllkfiln 661 flksfpifks gmnndwkniv nlddilemmi neddtnsetn timqhlqgfc qvfvtkflns 721 smsvsndpsv sieckslnem ikdfcsfisl qskfsclkli dcstrfrnai igdislksne 781 nllswlflnn vmgqllnycf evmkfvnglk v // LOCUS NP_013278 628 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR177W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013278 VERSION NP_013278.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182064.1 REFERENCE 1 (residues 1 to 628) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 628) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 628) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 628) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09497. Method: conceptual translation. FEATURES Location/Qualifiers source 1..628 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..628 /product="uncharacterized protein" /calculated_mol_wt="71135" Region 472..565 /region_name="PSP1" /note="PSP1 C-terminal conserved region; pfam04468" /db_xref="CDD:461321" CDS 1..628 /locus_tag="YLR177W" /coded_by="NM_001182064.1:1..1887" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; not an essential gene; YLR177W has a paralog, PSP1, that arose from the whole genome duplication" /db_xref="GeneID:850874" /db_xref="SGD:S000004167" ORIGIN 1 melpsinstt sisdnqelrn yydkllfknn sgksladlpg kmadfndnsa aahprsrvdf 61 ingyigfred kqsllgqknt krasfsafad egrkqsemsi ngkspnlslf sfefngtptq 121 drkpykqdyl nvmntspnni lsplnnssqk yypqkqqqqq qqqqqqqqqs ifdpgrrssy 181 isdalihgna atqqpqysqp vyinnnpslq vpytapseyt qqqqysspfn arrntqpvln 241 lhpaaaptnd aglavvdgkn ltsskelhdl yldcgsnyfa sdkvykfids ikgtlrgdnv 301 sasssriief ldflkncnln ynpqsdafis tavsnasstg aaksknstsm hlhykplvlv 361 slkngklell skpqtatlil krgdlviidg drgkdlvlvv epvvdinlal finflkkkih 421 fdslitnsqq hfpndqfikt lvdttngkpv ahelnpklyd iieltqliip skqvlrfatp 481 wesstnlhnk fqdelkalhi aqlklrslnn nnsggglnik ilnaefqfdr kkltfyyicq 541 erndfrdlik elfkfyktri wlcaipnnls idskfydsnk fewemyqdmm shysmdntgi 601 vvapelnrlk lddfqigvym elvkvlfg // LOCUS NP_013279 219 aa linear PLN 30-JUN-2025 DEFINITION Tfs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013279 VERSION NP_013279.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182065.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09498. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..219 /product="Tfs1p" /calculated_mol_wt="24226" Region 36..216 /region_name="PEBP_euk" /note="PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; cd00866" /db_xref="CDD:176644" Site order(95,109,111,152..155,161,163) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:176644" CDS 1..219 /gene="TFS1" /locus_tag="YLR178C" /gene_synonym="DKA1; NSP1" /coded_by="NM_001182065.1:1..660" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:17317927]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:17317927]" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17076703]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17317927]" /experiment="EXISTENCE:direct assay:GO:0030162 regulation of proteolysis [PMID:9521655]" /experiment="EXISTENCE:direct assay:GO:0030414 peptidase inhibitor activity [PMID:9521655]" /experiment="EXISTENCE:mutant phenotype:GO:0046578 regulation of Ras protein signal transduction [PMID:15075275]" /experiment="EXISTENCE:physical interaction:GO:0046578 regulation of Ras protein signal transduction [PMID:15075275]" /note="Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p); phosphatidylethanolamine-binding protein (PEBP) family member and ortholog of hPEBP1/RKIP, a natural metastasis suppressor; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850875" /db_xref="SGD:S000004168" ORIGIN 1 mnqaidfaqa sidsykkhgi ledvihdtsf qpsgilavey sssapvamgn tlptekarsk 61 pqfqftfnkq mqksvpqana yvpqdddlft lvmtdpdaps ktdhkwsefc hlvecdlkll 121 neathetsga teffasefnt kgsntlieym gpappkgsgp hryvfllykq pkgvdsskfs 181 kikdrpnwgy gtpatgvgkw akennlqlva snffyaetk // LOCUS NP_013280 201 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR179C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013280 VERSION NP_013280.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182066.1 REFERENCE 1 (residues 1 to 201) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 201) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 201) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 201) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09499. Method: conceptual translation. FEATURES Location/Qualifiers source 1..201 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..201 /product="uncharacterized protein" /calculated_mol_wt="22020" Region 30..190 /region_name="PEBP_euk" /note="PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes; cd00866" /db_xref="CDD:176644" Site order(79,93,95,126..129,135,137) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:176644" CDS 1..201 /locus_tag="YLR179C" /coded_by="NM_001182066.1:1..606" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095|PMID:17317927]" /note="hypothetical protein with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus" /db_xref="GeneID:850876" /db_xref="SGD:S000004169" ORIGIN 1 mssaivakln kediikdtvk dlafeilgel svsyvdsddi klgnpmpmea tqaaptikft 61 pfdksqlsae dklallmtdp dapsrtehkw sevchyiitd ipveygpggd iaisgkgvvr 121 nnyigpgppk nsgyhryvff lckqpkgads stftkvenii swgygtpgag aydyikennl 181 qlvganyymv enttvdfnyd m // LOCUS NP_013281 382 aa linear PLN 30-JUN-2025 DEFINITION methionine adenosyltransferase SAM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013281 VERSION NP_013281.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182067.1 REFERENCE 1 (residues 1 to 382) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 382) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 382) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 382) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09500. Method: conceptual translation. FEATURES Location/Qualifiers source 1..382 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..382 /product="methionine adenosyltransferase SAM1" /EC_number="2.5.1.6" /calculated_mol_wt="41687" Region 6..378 /region_name="S-AdoMet_synt" /note="S-adenosylmethionine synthetase; cd18079" /db_xref="CDD:350837" Site order(6..8,10,44,46,48,53,55..57,121..124,126,168,170,172, 189,191,230,233,244..246,248..251,254,259..266,268,272,304, 306..310,315..316,318) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:350837" Site order(10,16..18,42,57,100,103..104,120..121,166,168,193, 234,236..237,239,245,251..252,266..268,272,276,278,309) /site_type="active" /db_xref="CDD:350837" Site order(10,16..17,166,168,252) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350837" CDS 1..382 /gene="SAM1" /locus_tag="YLR180W" /gene_synonym="ETH10" /coded_by="NM_001182067.1:1..1149" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0004478 methionine adenosyltransferase activity [PMID:3316224]" /experiment="EXISTENCE:mutant phenotype:GO:0006555 methionine metabolic process [PMID:4580557]" /experiment="EXISTENCE:mutant phenotype:GO:0006556 S-adenosylmethionine biosynthetic process [PMID:17426150]" /experiment="EXISTENCE:mutant phenotype:GO:0062030 negative regulation of stress granule assembly [PMID:32609300]" /note="S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication" /db_xref="GeneID:850877" /db_xref="SGD:S000004170" ORIGIN 1 magtflftse svgeghpdki cdqvsdaild aclaedphsk vacetaaktg mimvfgeitt 61 kaqldyqkiv rdtikkigyd dsakgfdykt cnvlvaieqq spdiaqgvhe ekdledigag 121 dqgimfgyat detpeglplt illahklnma madarrdgsl awlrpdtktq vtveykddhg 181 rwvpqridtv vvsaqhadei ttedlraqlk seiiekvipr dmldentkyf iqpsgrfvig 241 gpqgdagltg rkiivdaygg assvgggafs gkdyskvdrs aayaarwvak slvaaglckr 301 vqvqfsyaig iaeplslhvd tygtatksde eiidiisknf dlrpgvlvke ldlarpiylp 361 tasyghftnq eypwekpktl kf // LOCUS NP_013282 330 aa linear PLN 30-JUN-2025 DEFINITION Vta1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013282 VERSION NP_013282.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182068.1 REFERENCE 1 (residues 1 to 330) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 330) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 330) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 330) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09501. Method: conceptual translation. FEATURES Location/Qualifiers source 1..330 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..330 /product="Vta1p" /calculated_mol_wt="37185" Region 10..161 /region_name="Vta1" /note="Vta1 like; pfam04652" /db_xref="CDD:461380" Region 294..328 /region_name="Vta1_C" /note="Vta1 C-terminal domain; pfam18097" /db_xref="CDD:465647" CDS 1..330 /gene="VTA1" /locus_tag="YLR181C" /coded_by="NM_001182068.1:1..993" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:16505166|PMID:16601096]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005771 multivesicular body [PMID:14701806]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:16505166]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:16505166]" /experiment="EXISTENCE:mutant phenotype:GO:0001671 ATPase activator activity [PMID:16505166]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12953057]" /note="Multivesicular body (MVB) protein; involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain" /db_xref="GeneID:850878" /db_xref="SGD:S000004171" ORIGIN 1 masnaarvva takdfdkvgl giigyylqly avelilseed rsqemtalat elldtieafk 61 keiggeseae dsdkslhvmn tlihdqekak iymlnftmsl yneklkqlkd gpwdvmlkrs 121 lwccidlfsc ilhlwkenis etstnslqkr ikyckiylsk lakgeigssd ektldyadfa 181 ddseeikded vdhqtsdlen nnndkvegla pkdqttsyep vdevpefidd adsvneeeqt 241 vdknedaitk deqqvvkkev dltrpsapse paaaehksyt kdeltkimdr askieqiqkl 301 akyaisalny edlptakdel tkaldllnsi // LOCUS NP_013283 803 aa linear PLN 30-JUN-2025 DEFINITION transcriptional regulator SWI6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013283 VERSION NP_013283.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182069.1 REFERENCE 1 (residues 1 to 803) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 803) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 803) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 803) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 803) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 803) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 803) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 803) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 803) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09502. Method: conceptual translation. FEATURES Location/Qualifiers source 1..803 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..803 /product="transcriptional regulator SWI6" /calculated_mol_wt="90429" Region 4..106 /region_name="Swi6_N" /note="Swi6 N-terminal domain; pfam18530" /db_xref="CDD:408317" Region <305..>511 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Site order(317,319,323..324,327..329,331..332,336,339,348,350, 352,356..357,360,402..403,405..406,410,441,467,469,471, 475..476,479..481,483..484,488,491,500) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 317..348 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 350..467 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 469..500 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..803 /gene="SWI6" /locus_tag="YLR182W" /gene_synonym="PSL8; SDS11" /coded_by="NM_001182069.1:1..2412" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:9719633]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12697814|PMID:8590795|PMID:24470217]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12697814|PMID:8590795]" /experiment="EXISTENCE:direct assay:GO:0030907 MBF transcription complex [PMID:8372350]" /experiment="EXISTENCE:direct assay:GO:0033309 SBF transcription complex [PMID:8423776|PMID:1832338]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9719633]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:2649246|PMID:3542227]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:9719633]" /experiment="EXISTENCE:mutant phenotype:GO:0010845 positive regulation of reciprocal meiotic recombination [PMID:9628912]" /experiment="EXISTENCE:mutant phenotype:GO:0033309 SBF transcription complex [PMID:8423776]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20641022]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3542227|PMID:2649246|PMID:20641022]" /experiment="EXISTENCE:physical interaction:GO:0033309 SBF transcription complex [PMID:1465410]" /note="Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators" /db_xref="GeneID:850879" /db_xref="SGD:S000004172" ORIGIN 1 maleevvryl gphneipltl trdsetghfl lkhflpilqq yhdtgninet npdsfptdee 61 rnkllahygi avntddrgel wielekclql lnmlnlfglf qdafefeepe tdqdeedpsh 121 sklpenktks enskdnissk rinnlqdmsl dsdahrelgs plkklkidts vidaesdstp 181 ntargkpndd inkgpsgdne nngtddndrt agpiitfthd ltsdflsspl kimkalpspv 241 vndneqkmkl eaflqrllfp eiqemptsln ndssnrnseg gssnqqqqhv sfdsllqevn 301 dafpntqlnl nipvdehgnt plhwltsian lelvkhlvkh gsnrlygdnm gesclvkavk 361 svnnydsgtf ealldylypc liledsmnrt ilhhiiitsg mtgcsaaaky yldilmgwiv 421 kkqnrpiqsg tnekeskpnd kngerkdsil enldlkwiia nmlnaqdsng dtclniaarl 481 gnisivdall dygadpfian ksglrpvdfg agtsklqntn ggdenskmvs kgdydgqkng 541 kakkirsqll knppettsli ndvqnllnsi skdyenetvq ynekleklhk elneqreela 601 nsreqlanvk qlkdeyslmq eqltnlkagi eeeeesfree skklgiiade ssgidwdsse 661 ydadepfkve flsdfledkl qknyegdisk lleaeskeqi meqirnqlpa ekiqsmlppt 721 vllkarinay krndkhltnv ldtistkqse lenkfrrvls lclkidenkv dnmldgllqa 781 issedpqdid tdemqdflkk has // LOCUS NP_013284 489 aa linear PLN 30-JUN-2025 DEFINITION Tos4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013284 VERSION NP_013284.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182070.1 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09503. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..489 /product="Tos4p" /calculated_mol_wt="55337" Region 96..230 /region_name="FHA_PLM2-like" /note="forkhead associated (FHA) domain found in Saccharomyces cerevisiae plasmid maintenance protein 2 (PLM2) and similar proteins; cd22699" /db_xref="CDD:438751" Site order(121..122,138..139,141,159,161..162) /site_type="other" /note="putative phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438751" CDS 1..489 /gene="TOS4" /locus_tag="YLR183C" /coded_by="NM_001182070.1:1..1470" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:15282802|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:22333912|PMID:12760057]" /experiment="EXISTENCE:mutant phenotype:GO:0010468 regulation of gene expression [PMID:26941319]" /note="Putative transcription factor, contains Forkhead Associated domain; binds chromatin; involved in expression homeostasis, buffering of mRNA synthesis rate against gene dosage changes during S phase; target of SBF transcription factor; expression is periodic and peaks in G1; involved in DNA replication checkpoint response; interacts with Rpd3 and Set3 histone deacetylase complexes; APCC(Cdh1) substrate; relative distribution to nucleus increases upon DNA replication stress" /db_xref="GeneID:850880" /db_xref="SGD:S000004173" ORIGIN 1 mssqfpsspy rtvdpysppn ykqqpncpss nyekagktas esignfgkgd yptpfpsssi 61 grvsspvrsn kvdaipsspa fpgqlaetsp kfssklssps rhtrvinael dpskistitv 121 grnssqcdva lcknkfisrv hasitylpqt nevkihcfsm nglivtyrkq fdcyqlkdtm 181 nnnnrayrlv prfsnekcvk eiqdeggfin ftleegdtvy mtyykgimld frqvllrisl 241 keknsssepl rfekkaefes esetkhmgsi rkhpliftdt smdrpkkilk dsnkisigsd 301 sgvaermlnh flnsksspls svssvdheeq tlrqdslssd knpmtmkkpk lnkrvlpskp 361 kksvkenlde lsrrnidvmh lqhiltnhla fanvqqtplf qlqqvnsqis elsrdelrsi 421 lsdakcvgvi yrhgkdaagk pldeeyfydl endddyerrn lvsslkggrt glrscrrthk 481 qyfwkkpak // LOCUS NP_013286 88 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL37 RPL37A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013286 VERSION NP_013286.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182072.1 REFERENCE 1 (residues 1 to 88) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 88) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 88) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 88) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 88) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09504. Method: conceptual translation. FEATURES Location/Qualifiers source 1..88 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..88 /product="60S ribosomal protein eL37 RPL37A" /calculated_mol_wt="9719" Region 1..85 /region_name="PTZ00073" /note="60S ribosomal protein L37; Provisional" /db_xref="CDD:240257" CDS 1..88 /gene="RPL37A" /locus_tag="YLR185W" /coded_by="NM_001182072.1:1..267" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23268442]" /experiment="EXISTENCE:genetic interaction:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23268442]" /note="Ribosomal 60S subunit protein L37A; required for processing of 27SB pre-rRNA and formation of stable 66S assembly intermediates; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37A has a paralog, RPL37B, that arose from the whole genome duplication" /db_xref="GeneID:850882" /db_xref="SGD:S000004175" ORIGIN 1 mgkgtpsfgk rhnkshtlcn rcgrrsfhvq kktcsscgyp aaktrsynwg akakrrhttg 61 tgrmrylkhv srrfkngfqt gsaskasa // LOCUS NP_013287 252 aa linear PLN 30-JUN-2025 DEFINITION 18S rRNA pseudouridine methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013287 VERSION NP_013287.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182073.1 REFERENCE 1 (residues 1 to 252) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 252) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 252) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 252) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09505. Method: conceptual translation. FEATURES Location/Qualifiers source 1..252 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..252 /product="18S rRNA pseudouridine methyltransferase" /EC_number="2.1.1.260" /calculated_mol_wt="27764" Region 41..246 /region_name="Nep1-like" /note="18S rRNA (pseudouridine(1248)-N1)-methyltransferase Nep1; cd18088" /db_xref="CDD:349961" Site order(71..72,88,90,94,97..98,101,103,136,188,228,230, 232..233,235..236,239..240,243) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:349961" Site order(180..182,206..207,209..210,212,225..228,230..232,234, 237) /site_type="other" /note="SAM binding site [chemical binding]" /db_xref="CDD:349961" CDS 1..252 /gene="EMG1" /locus_tag="YLR186W" /gene_synonym="NEP1" /coded_by="NM_001182073.1:1..759" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11694595|PMID:11935223]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:11694595]" /experiment="EXISTENCE:direct assay:GO:0005880 nuclear microtubule [PMID:11935223]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:16721597]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11694595]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:11694595]" /experiment="EXISTENCE:mutant phenotype:GO:0070037 rRNA (pseudouridine) methyltransferase activity [PMID:20972225]" /experiment="EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:20972225]" /note="Methyltransferase for rRNA; methylates pseudouridine 18S rRNA residue 1191; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independent of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and equivalent yeast mutation affects Emg1p dimerization and localization but not methyltransferase activity; human EMG1 complements lethality of null and ts mutant" /db_xref="GeneID:850883" /db_xref="SGD:S000004176" ORIGIN 1 mvedsrvrda lkggdqkalp aslvpqappv ltskdkitkr mivvlamasl ethkissngp 61 ggdkyvllnc ddhqgllkkm grdisearpd ithqclltll dspinkagkl qvyiqtsrgi 121 lievnptvri prtfkrfsgl mvqllhklsi rsvnseekll kviknpitdh lptkcrkvtl 181 sfdapvirvq dyieklddde sicvfvgama rgkdnfadey vdekvglsny plsasvacsk 241 fchgaedawn il // LOCUS NP_013288 1026 aa linear PLN 30-JUN-2025 DEFINITION Skg3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013288 VERSION NP_013288.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182074.1 REFERENCE 1 (residues 1 to 1026) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1026) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1026) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1026) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1026) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1026) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1026) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1026) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1026) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09506. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1026 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1026 /product="Skg3p" /calculated_mol_wt="113980" Region 103..220 /region_name="PH" /note="PH domain; pfam00169" /db_xref="CDD:459697" CDS 1..1026 /gene="SKG3" /locus_tag="YLR187W" /coded_by="NM_001182074.1:1..3081" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication" /db_xref="GeneID:850884" /db_xref="SGD:S000004177" ORIGIN 1 mkrifsgvks pklsappkvf kndespstps spkfdqglrs lsasasrlfs nsistpgspt 61 ldlpqehsin gdispelvpi vtllsaqahr ryhygiflil hdlktdgtpa arqweecygv 121 llgtqlalwd akelsdsknn kntstmkkaa srpsfinftd asvrsldand qviiasenek 181 tkkdldnvlv vsttlknryf lkfknsksfk twnaairlsl feftalqeay tgsflssrgv 241 klgdikvvma dtkftyedwv svrfgtgmpw krcyavispq sgkkkknskg sicfyennkk 301 tkksnimttv vdaralyavy psspilidts tiiklegfvs fdkseepqet nlfimpekhq 361 gvpgydtiir flipamnafy lygrpkglia nrtdpdsllf alptlphiyy lqvddvlslt 421 kdknyihwsa adwrnnivqv lqkklskgyk gcgnktvsvs sgmmkspais saelfegyds 481 lperqmespq kskmksptla stddinsasa svnshatsvk qtelfvtdns skindsvsaq 541 ssvttnfkdt fttpmtsgml nhensersfg sglklkitds nlenmedvea ksanefsttp 601 edkhihlana aelsalydky stspfgksea nsspkpqkle vkdrsknenr spyeryvgts 661 aesktfeign vreskstint slssplrved srrsknedlg slkefeelsq kisnmgmani 721 ssealsdtae nssfvtdlnl ninnsssvnl neeqrvpdfg eenvfdpdym eqnqmletes 781 ryttdefdfs dnqdaassny sngqtnrtvt etlsasdrnd kiphsslftn lnqltsnggn 841 yqdredfsgd qinkpqqsqp lhvkgpqtss fgyrnssans sqpqapypvg rplgkirtgp 901 ltvqpmqqgg nssmysfqss qhrfhssqqr qnqslsfrnn tygsgnnqnt fhpspqlqqq 961 pqnmrylnnk lpindrspip qtqhhvpdgr pslhinttnr tnpltaqsgf sqfmppnsts 1021 tnpyss // LOCUS NP_013289 695 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette permease MDL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013289 VERSION NP_013289.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182075.1 REFERENCE 1 (residues 1 to 695) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 695) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 695) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 695) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09507. Method: conceptual translation. FEATURES Location/Qualifiers source 1..695 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..695 /product="ATP-binding cassette permease MDL1" /calculated_mol_wt="75819" Region 82..679 /region_name="MdlB" /note="ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]; COG1132" /db_xref="CDD:440747" CDS 1..695 /gene="MDL1" /locus_tag="YLR188W" /coded_by="NM_001182075.1:1..2088" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11251115]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12746444]" /experiment="EXISTENCE:mutant phenotype:GO:0015421 ABC-type oligopeptide transporter activity [PMID:11251115]" /experiment="EXISTENCE:mutant phenotype:GO:0090374 oligopeptide export from mitochondrion [PMID:11251115]" /note="Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; may function as an influxer or possibly antiporter; plays a role in the regulation of cellular resistance to oxidative stress; ortholog of human ABCB10" /db_xref="GeneID:850885" /db_xref="SGD:S000004178" ORIGIN 1 mivrmirlck gpkllrsqfa sasalystks lfkppmyqka einliiphrk hfllrsirlq 61 sdiaqgkkst kptlklsnan skssgfkdik rlfvlskpes kyiglallli lisssvsmav 121 psvigklldl asesdgedee gsksnklygf tkkqfftalg avfiigavan asriiilkvt 181 gerlvarlrt rtmkaaldqd atfldtnrvg dlisrlssda sivaksvtqn vsdgtraiiq 241 gfvgfgmmsf lswkltcvmm ilapplgama liygrkirnl srqlqtsvgg ltkvaeeqln 301 atrtiqaygg eknevrryak evrnvfhigl keavtsglff gstglvgnta mlslllvgts 361 miqsgsmtvg elssfmmyav ytgsslfgls sfyselmkga gaaarvfeln drkplirpti 421 gkdpvslaqk pivfknvsft yptrpkhqif kdlnitikpg ehvcavgpsg sgkstiasll 481 lryydvnsgs iefgdedirn fnlrkyrrli gyvqqepllf ngtildnily cippeiaeqd 541 drirraigka nctkflanfp dglqtmvgar gaqlsggqkq rialarafll dpavlildea 601 tsaldsqsee ivaknlqrrv ergfttisia hrlstikhst rvivlgkhgs vvetgsfrdl 661 iaipnselna llaeqqdeeg kggvidldns varev // LOCUS NP_013290 1198 aa linear PLN 30-JUN-2025 DEFINITION sterol 3-beta-glucosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013290 VERSION NP_013290.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182076.1 REFERENCE 1 (residues 1 to 1198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1198) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09508. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1198 /product="sterol 3-beta-glucosyltransferase" /EC_number="2.4.1.173" /calculated_mol_wt="135924" Region 194..>239 /region_name="GRAM" /note="domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins; smart00568" /db_xref="CDD:214725" Region 219..335 /region_name="PH-GRAM1_AGT26" /note="Autophagy-related protein 26/Sterol 3-beta-glucosyltransferase Pleckstrin homology (PH) domain, repeat 1; cd13215" /db_xref="CDD:275402" Site order(247,257..259) /site_type="active" /note="putative lipid binding motif [active]" /db_xref="CDD:275402" Region 581..673 /region_name="PH-GRAM2_AGT26" /note="Autophagy-related protein 26/Sterol 3-beta-glucosyltransferase Pleckstrin homology (PH) domain, repeat 2; cd13216" /db_xref="CDD:275403" Site 600..602 /site_type="active" /note="putative lipid binding motif [active]" /db_xref="CDD:275403" Region 744..1155 /region_name="GT1_Gtf-like" /note="UDP-glycosyltransferases and similar proteins; cd03784" /db_xref="CDD:340817" Site order(751..752,754,902,905..906,910,937,998,1069,1071, 1073..1074,1077) /site_type="active" /db_xref="CDD:340817" Site order(751,998,1069,1071,1073..1074) /site_type="active" /note="TDP-binding site [active]" /db_xref="CDD:340817" Site 752 /site_type="active" /note="acceptor substrate-binding pocket [active]" /db_xref="CDD:340817" CDS 1..1198 /gene="ATG26" /locus_tag="YLR189C" /gene_synonym="UGT51" /coded_by="NM_001182076.1:1..3597" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016906 sterol 3-beta-glucosyltransferase activity [PMID:10224056]" /experiment="EXISTENCE:genetic interaction:GO:0032120 ascospore-type prospore membrane formation [PMID:18756268]" /experiment="EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:10224056]" /note="UDP-glucose:sterol glucosyltransferase; conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy" /db_xref="GeneID:850886" /db_xref="SGD:S000004179" ORIGIN 1 mpitqiisas dseagpkpsi slvpdkpsep etsprhhrls rslskfkrwr grsnsslsmg 61 sseqqelqds pnearsddde ngynndnadd lakskymmks iagllttasv yagmnnaqem 121 nvlsqvdsee sdssdsfqen igrnevkskk enlktkshpe vprldkrkpt lfdfsitrek 181 lskdnvaklr qrfcldeqep flndfpawll kdvlvqghif ittkhflffa ylpknprsvk 241 msgnlnirtk lirstrywcv lknhlfsmyt sstelyfpvl tidlrevqki etqkhtlngs 301 atktfklytd estfkfnads efsakswvna lkkeqfaaqn sennsislki plpniieidd 361 qpivnkaltl rlralessqt yaiddfmfvf mdgsgsqvke slgeqlailq ksgvntlyyd 421 ipakkskssf gketpatveq knngedskyl nvptsavpss engkksrfrf rersnswfrr 481 akpledsqve dveeiykdaa ndidssvhst ihiheqedsq eqtvawkpsh lknfaemwaa 541 kpihyrnkfi pfqkddtyli keteevsane rfryhfkfnk ekslistyyt ylnrnvpvyg 601 kiyvsndtvc frsllpgsnt ymvlplvdve tcykekgfrf gyfvlvivih gheelffefs 661 tevarddier illklldniy assaegsnis saslgdvqhn pdsaklklfe dkinaegfev 721 plmidenphy ktsikpnksy kfglltigsr gdvqpyialg kglikeghqv viithsefrd 781 fveshgiqfe eiagnpvelm slmvenesmn vkmlreassk frgwidallq tswevcnrrk 841 fdiliespsa mvgihiteal qipyfraftm pwtrtrayph afivpdqkrg gnynylthvl 901 fenvfwkgis gqvnkwrvet lglgktnlfl lqqnnvpfly nvsptifpps idfsewvrvt 961 gywflddkst fkppaelqef isearskgkk lvyigfgsiv vsnakemtea lveavmeadv 1021 ycilnkgwse rlgdkaakkt evdlprniln ignvphdwlf pqvdaavhhg gsgttgaslr 1081 aglptvikpf fgdqffyagr vedigvgial kklnaqtlad alkvattnki mkdraglikk 1141 kiskedgikt aisaiynele yarsvtlsrv ktprkkeenv datkltpaet tdegwtmi // LOCUS NP_013291 491 aa linear PLN 30-JUN-2025 DEFINITION Mmr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013291 VERSION NP_013291.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182077.1 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09509. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..491 /product="Mmr1p" /calculated_mol_wt="54686" Region 60..281 /region_name="MMR1" /note="Mitochondrial Myo2 receptor-related protein; pfam08505" /db_xref="CDD:400692" CDS 1..491 /gene="MMR1" /locus_tag="YLR190W" /coded_by="NM_001182077.1:1..1476" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:30044712]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:15201867]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:22119524]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:18245340|PMID:15201867]" /experiment="EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:15201867]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:18245340|PMID:15201867|PMID:35281729|PMID:22119524]" /experiment="EXISTENCE:mutant phenotype:GO:0048312 intracellular distribution of mitochondria [PMID:35281729|PMID:15201867|PMID:22119524]" /note="Phospholipid binding protein; interacts with mitochondria and with Myo2p, functioning as an adaptor that recruits Myo2p and facilitates actin-based transport of mitochondria to the bud; mediates mitochondria anchorage at the bud tip; phosphorylated protein that localizes to the mitochondrial outer membrane; mRNA is targeted to the bud via the transport system involving She2p; member of the DSL1 family of tethering proteins" /db_xref="GeneID:850887" /db_xref="SGD:S000004180" ORIGIN 1 mnsptmkseq ltpklspmsf clddqrnags fqnllnsptk lkldtgpign sllyptslsk 61 lselsrggrs kqrrgsdtmr svspirfqfl nntpkmlkpe ylsqttsnlp llsallknsk 121 kttsegqnsn pdplniekni ikqsikdkle qlrssesvaq vqkkernpps feakvcaeep 181 ilrknaegll psyvpvpatp ledpenhgvr kvedkglrvv sggstqclst evnelpkdln 241 ldnlptdnng fvqyglkgnn nnnrysfiss tstdyepewc dgqqhismqm asmanaeean 301 sreksnldik ikqleleite lklqneklvh smttnryiee rfmlevmkdp siqaqrsqrd 361 ierkvkqlek kffnckkvlk kltessavva tstsktegns aripcpktrl arvsvldlkk 421 ieeqpdsssg tsseedhltn ddtdantsed lnvafeeept saisttasvq sgeskrgfql 481 nlpvqvekke k // LOCUS NP_013292 386 aa linear PLN 30-JUN-2025 DEFINITION peroxin PEX13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013292 VERSION NP_013292.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182078.1 REFERENCE 1 (residues 1 to 386) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 386) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 386) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 386) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09510. Method: conceptual translation. FEATURES Location/Qualifiers source 1..386 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..386 /product="peroxin PEX13" /calculated_mol_wt="42575" Region 136..283 /region_name="Peroxin-13_N" /note="Peroxin 13, N-terminal region; pfam04088" /db_xref="CDD:461167" Region 310..369 /region_name="SH3_Pex13p_fungal" /note="Src Homology 3 domain of fungal peroxisomal membrane protein Pex13p; cd11771" /db_xref="CDD:212705" Site order(310,333,335,353,355) /site_type="other" /note="putative Pex5p binding site [polypeptide binding]" /db_xref="CDD:212705" Site order(315,320..321,324..325,345,348..349,361,363,365..366) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212705" CDS 1..386 /gene="PEX13" /locus_tag="YLR191W" /gene_synonym="PAS20" /coded_by="NM_001182078.1:1..1161" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:8858166|PMID:8858167]" /experiment="EXISTENCE:direct assay:GO:1902495 transmembrane transporter complex [PMID:20154681]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:20154681|PMID:22375831|PMID:12667447]" /experiment="EXISTENCE:genetic interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:10087260]" /experiment="EXISTENCE:physical interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:12595255|PMID:10087260|PMID:15798189]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:10087260|PMID:12595255]" /note="Peroxisomal importomer complex component; integral peroxisomal membrane protein required for docking and translocation of peroxisomal matrix proteins; interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p; forms a complex with Pex14p and Pex17p; human homolog PEX13 complements yeast null mutant" /db_xref="GeneID:850888" /db_xref="SGD:S000004181" ORIGIN 1 msstavprpk pwetsaslee pqrnaqslsa mmtsnqqdsr pteesnnsns asesapevlp 61 rpaalnssgt ygesntipgi ygnsnygipy dnnpysmnsi ygnsigrygy ggsyygnnyg 121 sfygggygag agygmnngsg lgestkatfq liesligavt gfaqmlesty mathnsfftm 181 isvaeqfgnl kemlgsffgi faimkflkki lyratkgrlg ippknfaese gsknkliedf 241 qkfndsgtin snekatrrki swkpllfflm avfgfpylln kfitklqtsg tirasqgngs 301 epidpsklef aralydfvpe npemevalkk gdlmailskk dplgrdsdww kvrtkngnig 361 yipynyieii krrkkiehvd detrth // LOCUS NP_013293 265 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF3 core subunit j [Saccharomyces cerevisiae S288C]. ACCESSION NP_013293 VERSION NP_013293.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182079.1 REFERENCE 1 (residues 1 to 265) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 265) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 265) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 265) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09511. Method: conceptual translation. FEATURES Location/Qualifiers source 1..265 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..265 /product="translation initiation factor eIF3 core subunit j" /calculated_mol_wt="29433" Region 2..215 /region_name="eIF3_subunit" /note="Translation initiation factor eIF3 subunit; pfam08597" /db_xref="CDD:462530" CDS 1..265 /gene="HCR1" /locus_tag="YLR192C" /coded_by="NM_001182079.1:1..798" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:38198768]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11560931]" /experiment="EXISTENCE:physical interaction:GO:0002181 cytoplasmic translation [PMID:11179233]" /experiment="EXISTENCE:physical interaction:GO:0003743 translation initiation factor activity [PMID:11179233]" /experiment="EXISTENCE:physical interaction:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:11179233]" /note="eIF3j component of translation initiation factor 3 (eIF3); role in initiation as a substoichiometric component of eIF3; 60S ribosomal subunit recycling accessory factor; involved in nonsense-mediated mRNA decay (NMD); required for 20S pre-rRNA processing; post-transcriptional role in retrotransposition; absence decreases Ty1 Gag protein levels; binds eIF3 subunits Rpg1p, Prt1p and 18S rRNA; eIF3 promotes programmed stop codon readthrough; human homolog EIF3J can complement a yeast null mutant" /db_xref="GeneID:850889" /db_xref="SGD:S000004182" ORIGIN 1 mswddeaing smgnddavlm dswdaeigdd epvmqswdae eeekkpapkp kkeqpkkvkk 61 gkessadral ldidtldekt rkelikkaem esdlnnaadl faglgvaeeh praralqkeq 121 eeqalkrpaf tkdtpiethp lfnaetkrey qdlrkaltaa itpmnkkspl nyssslaidl 181 irdvakpmsi esirqtvatl nvlikdkere erqarlarvr ggtatggagk kkvkgktnlg 241 gafkkdqdfd ldgpddfefg dddfm // LOCUS NP_013294 175 aa linear PLN 30-JUN-2025 DEFINITION Ups1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013294 VERSION NP_013294.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182080.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09512. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..175 /product="Ups1p" /calculated_mol_wt="19977" Region 16..170 /region_name="PRELI" /note="PRELI-like family; pfam04707" /db_xref="CDD:398400" CDS 1..175 /gene="UPS1" /locus_tag="YLR193C" /coded_by="NM_001182080.1:1..528" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:26235513]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:16754953|PMID:19506038]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:23042293]" /experiment="EXISTENCE:direct assay:GO:0045332 phospholipid translocation [PMID:26235513]" /experiment="EXISTENCE:direct assay:GO:1990050 phosphatidic acid transfer activity [PMID:23042293]" /experiment="EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:23042293]" /experiment="EXISTENCE:mutant phenotype:GO:0032048 cardiolipin metabolic process [PMID:19506038|PMID:19221197]" /experiment="EXISTENCE:mutant phenotype:GO:1990050 phosphatidic acid transfer activity [PMID:23042293]" /experiment="EXISTENCE:mutant phenotype:GO:2001247 positive regulation of phosphatidylcholine biosynthetic process [PMID:22403410]" /note="Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI" /db_xref="GeneID:850890" /db_xref="SGD:S000004183" ORIGIN 1 mvllhksthi fptdfasvsr affnrypnpy sphvlsidti srnvdqegnl rttrllkksg 61 klptwvkpfl rgitetwiie vsvvnpanst mktytrnldh tgimkveeyt tyqfdsatss 121 tiadsrvkfs sgfnmgiksk vedwsrtkfd envkksrmgm afviqkleea rnpqf // LOCUS NP_013295 254 aa linear PLN 30-JUN-2025 DEFINITION Ncw2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013295 VERSION NP_013295.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182081.1 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09513. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..254 /product="Ncw2p" /calculated_mol_wt="25631" CDS 1..254 /gene="NCW2" /locus_tag="YLR194C" /coded_by="NM_001182081.1:1..765" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:11016834]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11016834]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:mutant phenotype:GO:0006033 chitin localization [PMID:33945065]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:27246500]" /note="GPI-anchored protein involved in cell wall remodeling; involved in the assembly of the cell wall chitin-glucan structure and repair of damage caused by the antifungal agent polyhexamethylene biguanide; role in the cell wall integrity pathway; expression is upregulated in response to cell wall stress; transported to the cell surface after Pmt1p-Pmt2p-mediated O-mannosylation, colocalizing with bud scars" /db_xref="GeneID:850891" /db_xref="SGD:S000004184" ORIGIN 1 mkacsilftt litlaaaqkd sgsldgqnse dssqkessns qeitptttke aqesastvvs 61 tgkslvqtsn vvsntyavap sttvvttdaq gktttqylww vaesnsavst tstasvqptg 121 etssgitnsa sssttststd gpvtivtttn slgetytstv wwlpssattd ntasssksss 181 gssskpesst kvvstiksty tttsgstvet ltttykstvn gkvasvmsns tngafagthi 241 aygagafavg alll // LOCUS NP_013296 455 aa linear PLN 30-JUN-2025 DEFINITION glycylpeptide N-tetradecanoyltransferase NMT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013296 VERSION NP_013296.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182082.1 REFERENCE 1 (residues 1 to 455) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 455) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 455) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 455) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09514. Method: conceptual translation. FEATURES Location/Qualifiers source 1..455 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..455 /product="glycylpeptide N-tetradecanoyltransferase NMT1" /EC_number="2.3.1.97" /calculated_mol_wt="52707" Region 1..455 /region_name="NMT1" /note="N-myristoyl transferase [Lipid metabolism]; COG5092" /db_xref="CDD:227423" CDS 1..455 /gene="NMT1" /locus_tag="YLR195C" /gene_synonym="CDC72" /coded_by="NM_001182082.1:1..1368" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:1544917]" /experiment="EXISTENCE:mutant phenotype:GO:0004379 glycylpeptide N-tetradecanoyltransferase activity [PMID:8955162]" /note="N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction" /db_xref="GeneID:850892" /db_xref="SGD:S000004185" ORIGIN 1 mseedkakkl enllkllqln nddtskftqe qkkamkdhkf wrtqpvkdfd ekvveegpid 61 kpktpedisd kplpllssfe wcsidvdnkk qledvfvlln enyvedrdag frfnytkeff 121 nwalkspgwk kdwhigvrvk etqklvafis aipvtlgvrg kqvpsveinf lcvhkqlrsk 181 rltpvlikei trrvnkcdiw halytagivl papvstcryt hrplnwkkly evdftglpdg 241 hteedmiaen alpaktktag lrklkkedid qvfelfkryq srfeliqift keefehnfig 301 eeslpldkqv ifsyvveqpd gkitdffsfy slpftilnnt kykdlgigyl yyyatdadfq 361 fkdrfdpkat kalktrlcel iydacilakn anmdvfnalt sqdntlfldd lkfgpgdgfl 421 nfylfnyrak pitgglnpdn sndikrrsnv gvvml // LOCUS NP_013297 576 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein PWP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013297 VERSION NP_013297.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182083.1 REFERENCE 1 (residues 1 to 576) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 576) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 576) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 576) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09515. Method: conceptual translation. FEATURES Location/Qualifiers source 1..576 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..576 /product="rRNA-processing protein PWP1" /calculated_mol_wt="63672" Region <280..513 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 289..327 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 335..374 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 381..419 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 425..473 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 477..504 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..576 /gene="PWP1" /locus_tag="YLR196W" /coded_by="NM_001182083.1:1..1731" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:15588312]" /note="Protein with WD-40 repeats involved in rRNA processing; associates with rDNA chromatin in H4-tail-dependent manner; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily" /db_xref="GeneID:850893" /db_xref="SGD:S000004186" ORIGIN 1 misatnwvpr gfssefpeky vlddeeveri nqlaqlnldd akatleeaeg esgveddaat 61 gssnklkdql didddlkeyn leeyddeeia dneggkdvsm fpglsndsdv kfhegekged 121 pyislpnqed sqeekqelqv ypsdnlvlaa rteddvsyld iyvyddgagf hssdipveeg 181 deadpdvarg lvrdpalyvh hdlmlpafpl cvewldykvg snseeaanya aigtfdpqie 241 iwnldcvdka fpdmilgepl dnsmvslksk kkkkksktgh itthhtdavl smahnkyfrs 301 vlastsadht vklwdlnsgn aarslasihs nknvsssewh mlngsilltg gydsrvaltd 361 vrisdesqms kywsamagee ietvtfasen iilcgtdsgn vysfdirnne nrkpvwtlka 421 hdagistlcs nkfipgmmst gamgektvkl wkfplddatn tkgpsmvlsr dfdvgnvlts 481 sfapdievag tmviggvnkv lklwdvftnr svrksfksel envqarakee aqkigkssri 541 arkytsndnp dtvitiddqg edeeereggd ehddma // LOCUS NP_013298 504 aa linear PLN 30-JUN-2025 DEFINITION snoRNP complex protein NOP56 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013298 VERSION NP_013298.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182084.1 REFERENCE 1 (residues 1 to 504) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 504) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 504) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 504) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09516. Method: conceptual translation. FEATURES Location/Qualifiers source 1..504 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..504 /product="snoRNP complex protein NOP56" /calculated_mol_wt="56733" Region 6..72 /region_name="NOP5NT" /note="NOP5NT (NUC127) domain; pfam08156" /db_xref="CDD:462382" Region 181..413 /region_name="Nop" /note="snoRNA binding domain, fibrillarin; pfam01798" /db_xref="CDD:460335" CDS 1..504 /gene="NOP56" /locus_tag="YLR197W" /gene_synonym="SIK1" /coded_by="NM_001182084.1:1..1515" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11914276|PMID:9372940]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0031428 box C/D methylation guide snoRNP complex [PMID:11081632]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:10733567]" /experiment="EXISTENCE:physical interaction:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10733567]" /note="Essential evolutionarily-conserved nucleolar protein; component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects" /db_xref="GeneID:850894" /db_xref="SGD:S000004187" ORIGIN 1 mapieyllfe eptgyavfkv klqqddigsr lkevqeqind fgaftkliel vsfapfkgaa 61 ealenandis eglvseslka ildlnlpkas skkknitlai sdknlgpsik eefpyvdcis 121 nelaqdlirg vrlhgeklfk glqsgdlera qlglghaysr akvkfsvqkn dnhiiqaial 181 ldqldkdint famrvkewyg whfpelaklv pdnytfaklv lfikdkasln ddslhdlaal 241 lnedsgiaqr vidnarismg qdisetdmen vcvfaqrvas ladyrrqlyd ylcekmhtva 301 pnlseligev igarlishag sltnlskqaa stvqilgaek alfralktkg ntpkygliyh 361 sgfiskasak nkgrisryla nkcsmasrid nyseepsnvf gsvlkkqveq rlefyntgkp 421 tlknelaiqe amelynkdkp aaeveetkek esskkrkled ddeekkekke kkskkekkek 481 kekkdkkekk dkkekkdkkk kskd // LOCUS NP_013300 276 aa linear PLN 30-JUN-2025 DEFINITION Pba1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013300 VERSION NP_013300.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182086.1 REFERENCE 1 (residues 1 to 276) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 276) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 276) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 276) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09517. On Oct 2, 2003 this sequence version replaced NP_013300.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..276 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..276 /product="Pba1p" /calculated_mol_wt="30564" Region 1..276 /region_name="POC1" /note="POC1 chaperone; pfam10450" /db_xref="CDD:402193" CDS 1..276 /gene="PBA1" /locus_tag="YLR199C" /gene_synonym="POC1" /coded_by="NM_001182086.1:1..831" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0043248 proteasome assembly [PMID:17431397]" /note="Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; interaction with Pba1p-Add66p may affect function of the mature proteasome and its role in maintaining respiratory metabolism; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly" /db_xref="GeneID:850896" /db_xref="SGD:S000004189" ORIGIN 1 mlfkqwndlp epkhlldlpe isknlqslev cpvpkvefpq dldvpqysta vittkimnpl 61 fpknllqlts igeikttltv kspslpqssg khswnydenf pnevdpdqkn dtadetvygf 121 sfpiysfgkt llfsmeenfi sispifgnmi srsiisqlaq fspdiivigt sdkiasmkvm 181 tenectlqpp efitgfigsv ltqlivgpsk glkfkclvap segpngfekl slsdmgslvd 241 lcgqwlgfep sryseecyrl wrcdsaaiga qsglyi // LOCUS NP_013301 114 aa linear PLN 30-JUN-2025 DEFINITION tubulin-binding prefolding complex subunit YKE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013301 VERSION NP_013301.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182087.1 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09518. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..114 /product="tubulin-binding prefolding complex subunit YKE2" /calculated_mol_wt="13153" Region 6..103 /region_name="Prefoldin_6" /note="Prefoldin subunit 6; cd23161" /db_xref="CDD:467477" Region 6..42 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467477" Site order(8,16..22,24,52,62..63,65..67,69..71,73..74,76..78, 80..82,84..85,100..103) /site_type="other" /note="prefoldin beta subunit /TRiC interface [polypeptide binding]" /db_xref="CDD:467477" Site order(28,31..32,34..35,37..39,41,45..60,63..64,71,75) /site_type="other" /note="prefoldin oligomer interface [polypeptide binding]" /db_xref="CDD:467477" Region 62..103 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467477" CDS 1..114 /gene="YKE2" /locus_tag="YLR200W" /gene_synonym="GIM1; PFD6" /coded_by="NM_001182087.1:1..345" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9463374]" /experiment="EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:9463374]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9463374]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9463374]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:physical interaction:GO:0016272 prefoldin complex [PMID:9463374]" /note="Subunit of the heterohexameric Gim/prefoldin protein complex; involved in the folding of alpha-tubulin, beta-tubulin, and actin; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation" /db_xref="GeneID:850897" /db_xref="SGD:S000004190" ORIGIN 1 mselgakyqq lqneleefiv arqkletqlq enkivneefd qleedtpvyk ltgnvllpve 61 qseartnvdk rlefieteit rceknirdkq eelekmrsel iklnntaast gpgr // LOCUS NP_013302 260 aa linear PLN 30-JUN-2025 DEFINITION ubiquinone biosynthesis protein COQ9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013302 VERSION NP_013302.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182088.1 REFERENCE 1 (residues 1 to 260) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 260) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 260) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 260) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09519. Method: conceptual translation. FEATURES Location/Qualifiers source 1..260 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..260 /product="ubiquinone biosynthesis protein COQ9" /calculated_mol_wt="29827" Region 162..230 /region_name="COQ9" /note="pfam08511" /db_xref="CDD:462499" CDS 1..260 /gene="COQ9" /locus_tag="YLR201C" /coded_by="NM_001182088.1:1..783" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:17391640|PMID:16027161]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:16027161]" /experiment="EXISTENCE:physical interaction:GO:0006744 ubiquinone biosynthetic process [PMID:17391640]" /note="Protein required for ubiquinone biosynthesis and respiratory growth; localizes to matrix face of mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; ubiquinone is also known as coenzyme Q; human homolog COQ9 can complement yeast coq9 null mutant" /db_xref="GeneID:850898" /db_xref="SGD:S000004191" ORIGIN 1 mlcrntartg ckffrlyhsn piehvkpihi kpltygkesp qykvlslalq kfvpehgfse 61 rsiveslnel gypssmissi gapnspsffh sstavmelik fqlvdkryrl teginpdvtp 121 qyklpslehl llkrlemdkp igghlselms qlaipsaflf etaipelhrl sddmiyfsne 181 kdhhdsawya krlavsstyi gsklfmaqdk shnyketftf akdklhrvmr lgeyynntee 241 fawytlmstv nliksqlvrg // LOCUS NP_013304 436 aa linear PLN 30-JUN-2025 DEFINITION Mss51p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013304 VERSION NP_013304.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182090.1 REFERENCE 1 (residues 1 to 436) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 436) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 436) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 436) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09520. Method: conceptual translation. FEATURES Location/Qualifiers source 1..436 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..436 /product="Mss51p" /calculated_mol_wt="50749" Region 85..135 /region_name="zf-Mss51" /note="Zinc-finger of mitochondrial splicing suppressor 51; pfam13824" /db_xref="CDD:433505" Region 224..409 /region_name="MSS51_C" /note="MSS51 C-terminal domain; pfam20179" /db_xref="CDD:466330" CDS 1..436 /gene="MSS51" /locus_tag="YLR203C" /coded_by="NM_001182090.1:1..1311" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0070131 positive regulation of mitochondrial translation [PMID:15306853]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:15306853]" /experiment="EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:19710419]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:19710419|PMID:15306853]" /experiment="EXISTENCE:physical interaction:GO:0070131 positive regulation of mitochondrial translation [PMID:15306853]" /note="Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; localizes to vacuole membrane in response to H2O2; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase; binds to heme B, which may be a mechanism for sensing oxygen levels in order to regulate cytochrome c oxidase biogenesis" /db_xref="GeneID:850900" /db_xref="SGD:S000004193" ORIGIN 1 mtvlyapsga tqlyfhllrk sphnrlvvsh qtrrhlmgfv rnalgldppp spedptpenr 61 fhpwdqspsv dlreraakir tlahcpvtgk dinytcplsg ipthhsreaw emdkayhdsk 121 kyeilkkvni yehdlrsgrp fpefdfpqqq gydkavnltn wdlffytrsf ysmdtefqla 181 avtkmlsypi tigsllhkfs pyslnpkgpi tleglkslaa lrytlyplen rslptttknr 241 amrifilgar aeaqlpghvw kqlqflfpeq sfeihfigpe clykrdkqey vksttpvvqr 301 vdetlkfiyr tnffevfhea qdffpydpym dvfftfhpgy aspeshgswm getmkallet 361 kcaifttgfn kkdltddinl vkskygkemd vlmepvrnvf gstkwelndm npqevyqfnm 421 yiagfrgkry htikrq // LOCUS NP_013305 111 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS38 QRI5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013305 VERSION NP_013305.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182091.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09521. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..111 /product="mitochondrial 37S ribosomal protein mS38 QRI5" /calculated_mol_wt="12641" CDS 1..111 /gene="QRI5" /locus_tag="YLR204W" /gene_synonym="COX24; mS38" /coded_by="NM_001182091.1:1..336" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16339141]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:16339141]" /experiment="EXISTENCE:mutant phenotype:GO:0061668 mitochondrial ribosome assembly [PMID:30968120]" /experiment="EXISTENCE:mutant phenotype:GO:0070124 mitochondrial translational initiation [PMID:30968120]" /note="Mitochondrial inner membrane protein; required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA" /db_xref="GeneID:850901" /db_xref="SGD:S000004194" ORIGIN 1 mlgralrpgw lgitrtvvkk pscgsyfnrt fqtainttmp pmqegmlstm mmmtatatri 61 tgtvseplng snivmqldsv mrkrkkkmkk hklrkrrkre kaerrklsqg r // LOCUS NP_013306 317 aa linear PLN 30-JUN-2025 DEFINITION Hmx1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013306 VERSION NP_013306.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182092.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09522. On Feb 23, 2004 this sequence version replaced NP_013306.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..317 /product="Hmx1p" /calculated_mol_wt="37048" Region 17..254 /region_name="HemeO" /note="heme oxygenase in eukaryotes and some bacteria; cd19165" /db_xref="CDD:350856" Site order(23,30,33..34,39,43,156..158,164..165,169,213,217,244, 247,251) /site_type="other" /note="heme binding site [chemical binding]" /db_xref="CDD:350856" Region 149..176 /region_name="kinked helix" /note="kinked helix [structural motif]" /db_xref="CDD:350856" CDS 1..317 /gene="HMX1" /locus_tag="YLR205C" /coded_by="NM_001182092.1:1..954" /experiment="EXISTENCE:direct assay:GO:0004392 heme oxygenase (decyclizing) activity [PMID:17144670]" /experiment="EXISTENCE:direct assay:GO:0005640 nuclear outer membrane [PMID:21081499]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12840010]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11566881]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:12840010]" /experiment="EXISTENCE:mutant phenotype:GO:0006979 response to oxidative stress [PMID:21081499]" /experiment="EXISTENCE:mutant phenotype:GO:0042167 heme catabolic process [PMID:12840010]" /note="ER localized heme oxygenase; involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants" /db_xref="GeneID:850902" /db_xref="SGD:S000004195" ORIGIN 1 medssntiip sptdvgalan rinfqtrdah nkintfmgik maiamrhgfi yrqgilayyy 61 vfdaieqeid rllndpvtee elqtstilkq fwledfrrst qiykdlklly sntfkstesl 121 neflatfqkp pllqqfinni henihkepct ilsychvlyl alfaggklir snlyrrlglf 181 pnfeklsqke lvkkgtnfft fsdlgpteet rlkweykkny elatrtelte aqklqiisva 241 egifdwnfni vaeigelnrr elmgkfsfkc itylyeewmf nkdsatrral htvmllvlsi 301 iaiwvlyflv ksflsiv // LOCUS NP_013307 613 aa linear PLN 30-JUN-2025 DEFINITION epsin [Saccharomyces cerevisiae S288C]. ACCESSION NP_013307 VERSION NP_013307.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182093.1 REFERENCE 1 (residues 1 to 613) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 613) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 613) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 613) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09523. Method: conceptual translation. FEATURES Location/Qualifiers source 1..613 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..613 /product="epsin" /calculated_mol_wt="71676" Region 15..145 /region_name="ENTH_Ent1_Ent2" /note="Epsin N-Terminal Homology (ENTH) domain of Yeast Ent1, Ent2, and similar proteins; cd16991" /db_xref="CDD:340788" Site order(24,28..29,62,68,72) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:340788" Site order(60,63..64,100..101,103..110,123,127) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:340788" CDS 1..613 /gene="ENT2" /locus_tag="YLR206W" /coded_by="NM_001182093.1:1..1842" /experiment="EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:10449404]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:10449404]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10449404]" /note="Epsin-like protein required for endocytosis and actin patch assembly; K48-, K63-specific Ub chain binding protein that functions as an endocytic adaptor; contains clathrin-binding motif at C-terminus; functionally redundant with Ent1p; ENT2 has a paralog, ENT1, that arose from the whole genome duplication" /db_xref="GeneID:850903" /db_xref="SGD:S000004196" ORIGIN 1 mskqfvrsak nmmkgysstq vlvrdatand srtpsidtld dlaqrsydsv dffeimdmld 61 krlndkgkyw rhvaksltvl dylvrfgsen cvlwcrenfy viktlrefrh enesgfdegq 121 iirvkakelv sllndeerlr eersmntrnr ranraarprp rrqrtrsnph dsspsyqddl 181 ekaleesrit aqedeqrrre laqyddedpd fqaalqlske eeelkqlqel qrlqkqqqsl 241 sqfqaplqqq qpqqqpayyd ifgnpisqde ylqyqyqqdq eqamaqqrwl dqqqeqqqla 301 eqqyfqqqqq aaaaasalqq qqtaanmqqq qqqpadfqqp lptgsnnpfs mdnlerqkqe 361 qqhaqlqrqq eearqqqeql klqqlqrqqq eeaqlhqkrq eeaqlqqqqa qllqqqaqfq 421 qqqplkqtrt gnqsisdkys dlntllatgt gidtfgntge aripaqhtkt gtfinsqgtg 481 ykqvtnepkn npflsnqytg lpstnivptq tgygfgnqpq spptnspqqn ptgisysqpq 541 qqqqpqqqpq ymqnfqqqqp qyaqnfqqqp qytqnyqqqp qyiqphqqqq qqqqqqqqqq 601 gytpdqgvsl idl // LOCUS NP_013308 833 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin ligase complex subunit HRD3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013308 VERSION NP_013308.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182094.1 REFERENCE 1 (residues 1 to 833) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 833) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 833) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 833) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 833) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09524. Method: conceptual translation. FEATURES Location/Qualifiers source 1..833 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..833 /product="ubiquitin ligase complex subunit HRD3" /calculated_mol_wt="95350" Region 90..115 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region <104..>220 /region_name="TPR" /note="TPR repeat [General function prediction only]; COG0790" /db_xref="CDD:440553" Region 123..155 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 170..199 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region <534..664 /region_name="TPR" /note="TPR repeat [General function prediction only]; COG0790" /db_xref="CDD:440553" Region 537..564 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 579..608 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" Region 611..640 /region_name="SLR repeat" /note="SLR repeat [structural motif]" /db_xref="CDD:276807" CDS 1..833 /gene="HRD3" /locus_tag="YLR207W" /coded_by="NM_001182094.1:1..2502" /experiment="EXISTENCE:direct assay:GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:11390656]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0034099 luminal surveillance complex [PMID:16873065]" /experiment="EXISTENCE:direct assay:GO:0036503 ERAD pathway [PMID:12105183]" /experiment="EXISTENCE:direct assay:GO:1905524 negative regulation of protein autoubiquitination [PMID:31713515]" /experiment="EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:24292014]" /experiment="EXISTENCE:physical interaction:GO:0005789 endoplasmic reticulum membrane [PMID:16619026]" /note="ER membrane protein that plays a central role in ERAD; forms HRD complex with Hrd1p and ER-associated protein degradation (ERAD) determinants that engages in lumen to cytosol communication and coordination of ERAD events" /db_xref="GeneID:850904" /db_xref="SGD:S000004197" ORIGIN 1 mitlllylcv icnaivlira dsiadpwpea rhllntiaks rdpmkeaame pnadefvgfy 61 vpmdysprne eknyqsiwqn eitdsqrhiy ellvqsseqf nnseatytls qihlwsqynf 121 phnmtlahky lekfndlthf tnhsaifdla vmyatggcas gndqtvipqd sakallyyqr 181 aaqlgnlkak qvlaykyysg fnvprnfhks lvlyrdiaeq lrksysrdew divfpywesy 241 nvrisdfesg llgkglnsvp sstvrkrttr pdigspfiaq vngvqmtlqi epmgrfafng 301 ndgningded dedaserrii riyyaalndy kgtysqsrnc eraknllelt ykefqphvdn 361 ldplqvfyyv rclqllghmy ftgegsskpn ihmaeeiltt sleisrraqg pigracidlg 421 linqyitnni sqaisyymka mktqanngiv efqlsklats fpeekigdpf nlmetaylng 481 fipaiyefav miesgmnsks sventaylfk tfvdkneaim apklrtafaa lindrseval 541 waysqlaeqg yetaqvsaay lmyqlpyefe dpprttdqrk tlaisyytra fkqgnidagv 601 vagdiyfqmq nyskamalyq gaalkysiqa iwnlgymheh glgvnrdfhl akryydqvse 661 hdhrfylask lsvlklhlks wltwitrekv nywkpsspln pnedtqhskt swykqltkil 721 qrmrhkedsd kaaedshkhr tvvqnganhr gddqeeasei lgfqmedlvt mgcilgifll 781 silmstlaar rgwnvrfnga qlnangnrqq eqqqqqqaqg ppgwdfnvqi fai // LOCUS NP_013309 297 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein SEC13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013309 VERSION NP_013309.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182095.1 REFERENCE 1 (residues 1 to 297) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 297) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 297) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 297) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09525. Method: conceptual translation. FEATURES Location/Qualifiers source 1..297 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..297 /product="GTPase-activating protein SEC13" /calculated_mol_wt="32912" Region <21..281 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 57..97 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 102..141 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 149..197 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 207..249 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 257..283 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..297 /gene="SEC13" /locus_tag="YLR208W" /gene_synonym="ANU3" /coded_by="NM_001182095.1:1..894" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12671686|PMID:17604721]" /experiment="EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:11717432|PMID:8004676]" /experiment="EXISTENCE:direct assay:GO:0031080 nuclear pore outer ring [PMID:11823431|PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]" /experiment="EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:22300850]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:12538638]" /experiment="EXISTENCE:mutant phenotype:GO:0051664 nuclear pore localization [PMID:10747086]" /experiment="EXISTENCE:mutant phenotype:GO:0090114 COPII-coated vesicle budding [PMID:8223424|PMID:8432727]" /experiment="EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:23974112]" /note="Structural component of 3 complexes; subunit of the Nup84p nuclear pore subcomplex that contributes to nucleocytoplasmic transport and NPC biogenesis; subunit of the COPII vesicle coat required for ER-to-Golgi transport; subunit of SEACAT, a subcomplex of the coatomer-related, vacuolar-associated SEA complex, that inhibits the TORC1 inhibitory role of SEACIT (Iml1p-Npr2p-Npr3p), a GAP for Gtr1p, thereby resulting in activation of TORC1 signaling; human SEC13 homolog" /db_xref="GeneID:850905" /db_xref="SGD:S000004198" ORIGIN 1 mvvianahne lihdavldyy gkrlatcssd ktikifeveg ethklidtlt ghegpvwrvd 61 wahpkfgtil ascsydgkvl iwkeengrws qiavhavhsa svnsvqwaph eygplllvas 121 sdgkvsvvef kengttspii idahaigvns aswapatiee dgehngtkes rkfvtggadn 181 lvkiwkynsd aqtyvlestl eghsdwvrdv awsptvllrs ylasvsqdrt ciiwtqdneq 241 gpwkktllke ekfpdvlwra swslsgnvla lsggdnkvtl wkenlegkwe pagevhq // LOCUS NP_013310 311 aa linear PLN 30-JUN-2025 DEFINITION purine-nucleoside phosphorylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013310 VERSION NP_013310.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182096.1 REFERENCE 1 (residues 1 to 311) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 311) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 311) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 311) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09526. Method: conceptual translation. FEATURES Location/Qualifiers source 1..311 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..311 /product="purine-nucleoside phosphorylase" /EC_number="2.4.2.1" /calculated_mol_wt="33624" Region 12..307 /region_name="PNP-EcPNPII_like" /note="purine nucleoside phosphorylases similar to human PNP and Escherichia coli PNP-II (XapA); cd09009" /db_xref="CDD:350160" Site order(45..46,101,103,105,132..136,213,218..219,224, 235..238,260..263,284,286,289) /site_type="active" /db_xref="CDD:350160" Site order(45..46,81,101,103,133..134,238) /site_type="other" /note="phosphate binding site [ion binding]" /db_xref="CDD:350160" Site order(46,103,105,134..136,218..219,235..237,260..261,286, 289) /site_type="other" /note="purine nucleoside binding site [chemical binding]" /db_xref="CDD:350160" Site order(104..108,151..155,159..160,162..163,165..166, 177..183,186,189,193,209,212..223,225..226,228..230,237, 244,264,269,283..284,286) /site_type="other" /note="homotrimer interface [polypeptide binding]" /db_xref="CDD:350160" CDS 1..311 /gene="PNP1" /locus_tag="YLR209C" /coded_by="NM_001182096.1:1..936" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:17482543]" /experiment="EXISTENCE:direct assay:GO:0004731 purine-nucleoside phosphorylase activity [PMID:11466296]" /experiment="EXISTENCE:direct assay:GO:0047724 inosine nucleosidase activity [PMID:19001417]" /experiment="EXISTENCE:direct assay:GO:0070635 nicotinamide riboside hydrolase activity [PMID:19001417]" /experiment="EXISTENCE:genetic interaction:GO:0019358 nicotinate nucleotide salvage [PMID:17482543]" /experiment="EXISTENCE:genetic interaction:GO:0034355 NAD+ biosynthetic process via the salvage pathway [PMID:19001417]" /experiment="EXISTENCE:mutant phenotype:GO:0004731 purine-nucleoside phosphorylase activity [PMID:11466296]" /experiment="EXISTENCE:mutant phenotype:GO:0006148 inosine catabolic process [PMID:23670538|PMID:11466296]" /experiment="EXISTENCE:mutant phenotype:GO:0046115 guanosine catabolic process [PMID:23670538|PMID:11466296]" /note="Purine nucleoside phosphorylase; specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway" /db_xref="GeneID:850906" /db_xref="SGD:S000004199" ORIGIN 1 msdilnvsqq reaitkaaay isailephfk nttnfepprt liicgsglgg istklsrdnp 61 ppvtvpyqdi pgfkkstvpg hsgtlmfgsm ngspvvlmng rlhgyegntl fettfpirvl 121 nhmghvrnli vtnaaggina kyqacdlmci ydhlnipgla gqhplrgpnl dedgprflal 181 sdaydlelrk llfkkwkelk iqrplhegty tfvsgptfet raeskmirml ggdavgmstv 241 pevivarhcg wrvlalslit ntcvvdspas aldespvple kgkathaevl engkiasndv 301 qnliaavmge l // LOCUS NP_013311 460 aa linear PLN 30-JUN-2025 DEFINITION B-type cyclin CLB4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013311 VERSION NP_013311.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182097.1 REFERENCE 1 (residues 1 to 460) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 460) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 460) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 460) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09527. Method: conceptual translation. FEATURES Location/Qualifiers source 1..460 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..460 /product="B-type cyclin CLB4" /calculated_mol_wt="53722" Region 10..459 /region_name="COG5024" /note="Cyclin [Cell division and chromosome partitioning]" /db_xref="CDD:227357" Site order(206..207,210..211,214..215,218,291..292,295..299, 302..304,321,324..325,328..329,332..333) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410271" CDS 1..460 /gene="CLB4" /locus_tag="YLR210W" /coded_by="NM_001182097.1:1..1383" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12972503|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12972503]" /experiment="EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:16688214|PMID:1387566|PMID:11438663]" /experiment="EXISTENCE:genetic interaction:GO:1901673 regulation of mitotic spindle assembly [PMID:8319908]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:1427070]" /experiment="EXISTENCE:mutant phenotype:GO:0001932 regulation of protein phosphorylation [PMID:8455600]" /experiment="EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:8455600]" /note="B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; prevents premature sister centromere separation during meiosis I in Y55 and SK1 but not W303; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; CLB4 has a paralog, CLB3, that arose from the whole genome duplication" /db_xref="GeneID:850907" /db_xref="SGD:S000004200" ORIGIN 1 mmlegytvqp pqstligdie iqdenanqev knvlyqgvqk gikrlekrqr rvalgdvtsq 61 kankihnaih nkfhqtknnf eienirssal vkeqqrdvrh edsdyflids segsstddeq 121 vnedaiddll srrvndqqiq adevyedfdg emqdvieedv dsqieplspi nndeiqteld 181 rafekyfrsv pnpldddthd vvmvveyasd ifyylrelev kyrpnpyymq nqveltwpfr 241 rtmidwlvql hfrfqllpet lyltinivdr flskktvtln rfqlvgvsal fiaakfeein 301 cptlddlvym lentytrddi iraeqymidt lefeigwpgp mpflrriska ddydfeprtl 361 akyllettiv epklvaaaps wlaagayfls rtilgsndws lkhvfysgyt ssqiiplasl 421 ilencknasr rhhsiwkkyf dqkhyrcsqi veewivstea // LOCUS NP_013312 226 aa linear PLN 30-JUN-2025 DEFINITION Atg38p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013312 VERSION NP_013312.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182098.1 REFERENCE 1 (residues 1 to 226) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 226) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 226) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09528. On Aug 9, 2000 this sequence version replaced NP_013312.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..226 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..226 /product="Atg38p" /calculated_mol_wt="25844" CDS 1..226 /gene="ATG38" /locus_tag="YLR211C" /coded_by="NM_001182098.1:1..681" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:24165940]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:24165940]" /experiment="EXISTENCE:direct assay:GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I [PMID:24165940]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:24165940]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:24165940]" /note="Homodimeric subunit of autophagy-specific PtdIns-3-kinase complex I; required for the integrity of the active PtdIns-3-kinase complex I by maintaining an association between Vps15p-Vps34p and Atg14p-Vps30p subcomplexes; localizes to the pre-autophagosomal structure (PAS) in an Atg14p-dependent manner; ATG38 is non-essential but is required for macroautophagy" /db_xref="GeneID:850908" /db_xref="SGD:S000004201" ORIGIN 1 mstlaevyti iedaeqecrk gdftnakaky qeaievlgpq nenlsqnkls sdvtqaidll 61 kqditakiqe lelliekqss eennigmvnn nmligsviln nkspingisn arnwdnpayq 121 dtlspindpl lmsilnrlqf nlnndiqlkt eggknsknse mkinlrleqf kkelvlyeqk 181 kfkeygmkid eitkenkkla neigrlrerw dslvesakqr rdkqkn // LOCUS NP_013313 473 aa linear PLN 30-JUN-2025 DEFINITION gamma-tubulin [Saccharomyces cerevisiae S288C]. ACCESSION NP_013313 VERSION NP_013313.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182099.1 REFERENCE 1 (residues 1 to 473) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 473) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 473) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 473) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 473) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09529. Method: conceptual translation. FEATURES Location/Qualifiers source 1..473 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..473 /product="gamma-tubulin" /calculated_mol_wt="52497" Region 3..437 /region_name="gamma_tubulin" /note="The gamma-tubulin family; cd02188" /db_xref="CDD:276957" Site order(3,49,134,251,253,257,260..261,263..264,328..329, 331..332,335..336,339,349..350,353..354,432,435..436) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:276957" Site order(11..13,16,103,141,143..147,172,174,206,224,227..228) /site_type="other" /note="nucleotide binding site [chemical binding]" /db_xref="CDD:276957" CDS 1..473 /gene="TUB4" /locus_tag="YLR212C" /coded_by="NM_001182099.1:1..1422" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005822 inner plaque of spindle pole body [PMID:9215630]" /experiment="EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:9215630]" /experiment="EXISTENCE:direct assay:GO:0007020 microtubule nucleation [PMID:24842996|PMID:11950928]" /experiment="EXISTENCE:direct assay:GO:0008275 gamma-tubulin small complex [PMID:9384578|PMID:25599398|PMID:9130700]" /experiment="EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:8557744]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:9153752]" /experiment="EXISTENCE:mutant phenotype:GO:0051417 microtubule nucleation by spindle pole body [PMID:8707828]" /experiment="EXISTENCE:mutant phenotype:GO:2000767 positive regulation of cytoplasmic translation [PMID:26310304]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9130700|PMID:8670895]" /experiment="EXISTENCE:physical interaction:GO:0008275 gamma-tubulin small complex [PMID:9130700]" /note="Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress; null mutation is complemented by human TUBG1" /db_xref="GeneID:850909" /db_xref="SGD:S000004202" ORIGIN 1 mggeiitlqa gqcgnhvgkf lwsqlakeha igtdglsqlp dssterdddt kpffrensrn 61 kftpraimmd sepsviadve ntfrgffdpr ntwvasdgas agnswangyd igtrnqddil 121 nkidkeidst dnfegfqllh svaggtgsgl gsnllealcd rypkkiltty svfparssev 181 vvqsyntila lrrliedsda tvvfdnasll nisgkvfrnp nidlqhtnql istiissvtn 241 sirfpsymys smssiystli pspelhflsp sftpftsdyi hddiahkghs sydvmldlld 301 psnslvstam nnptyfnvyn tiignveprq isramtklqq rikfpswsss amhvnigrrs 361 pylplqpnen evsgmmlsnm stvvnvfena cntfdkvfak gaflnnynvg dlfqsmqnvq 421 defaesrevv qslmedyvaa eqdsylddvl vddenmvgel eedldadgdh klv // LOCUS NP_013314 422 aa linear PLN 30-JUN-2025 DEFINITION putative glycosylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013314 VERSION NP_013314.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182100.1 REFERENCE 1 (residues 1 to 422) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 422) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 422) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 422) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09530. Method: conceptual translation. FEATURES Location/Qualifiers source 1..422 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..422 /product="putative glycosylase" /calculated_mol_wt="47225" Region 29..75 /region_name="ChtBD1_GH16" /note="Hevein or Type 1 chitin binding domain subfamily that co-occurs with family 16 glycosyl hydrolases; cd06923" /db_xref="CDD:211314" Site order(45,47..49,51,55) /site_type="other" /note="carbohydrate binding site [chemical binding]" /db_xref="CDD:211314" Region 143..354 /region_name="GH16_fungal_CRH1_transglycosylase" /note="glycosylphosphatidylinositol-glucanosyltransferase; cd02183" /db_xref="CDD:185692" Site order(177,205,207,209,217,219,221,231,233,246,307,309) /site_type="active" /db_xref="CDD:185692" Site order(217,219,221) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:185692" CDS 1..422 /gene="CRR1" /locus_tag="YLR213C" /coded_by="NM_001182100.1:1..1269" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:15470107]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15470107]" /note="Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation" /db_xref="GeneID:850910" /db_xref="SGD:S000004203" ORIGIN 1 mrisilqlvp vvgyigfalg elykpknsis cspnnpcpae wpccspynec gagpicvggc 61 nvrssfdees capipalvas qklefvstpk vpkfivnyqp kppiregngp nkantkvgvv 121 egelnskrii hyakflvtpd skeaekmled fdfthsgyts ieassgnivl ampkkttgsl 181 itstrsflyg kasvrmktar srgvvtafdl tsaigdeidf ewlggdlmta qsnyysqghl 241 dytrmqrfpv gadtwatyht yeidwdpdri iwyvdgkiar tvlkkdtwdp iskeyrypqt 301 pmrleiavwp ggsetngpgt inwagglidw enspdiiekg qftahveqit vtpyqnkfte 361 qvqfcikakk kaptfsqkdl srvvvsynrq drlnhhdegs lkwdcfvtpk indwlsswkr 421 sk // LOCUS NP_013315 686 aa linear PLN 30-JUN-2025 DEFINITION ferric/cupric-chelate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013315 VERSION NP_013315.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182101.1 REFERENCE 1 (residues 1 to 686) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 686) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 686) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 686) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09531. Method: conceptual translation. FEATURES Location/Qualifiers source 1..686 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..686 /product="ferric/cupric-chelate reductase" /EC_number="1.16.1.9" /calculated_mol_wt="78723" Region 26..84 /region_name="CFEM" /note="CFEM domain; pfam05730" /db_xref="CDD:399033" Region 260..375 /region_name="Ferric_reduct" /note="Ferric reductase like transmembrane component; pfam01794" /db_xref="CDD:426438" Region 414..684 /region_name="NOX_Duox_like_FAD_NADP" /note="NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; cd06186" /db_xref="CDD:99783" Site order(443,462..465,483..485,489..492,537) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(462,464..465) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99783" Site 532..542 /site_type="other" /note="NAD pyrophosphate binding region [chemical binding]" /db_xref="CDD:99783" Site order(532,536..539,541) /site_type="other" /note="beta-alpha-beta stucture motif" /db_xref="CDD:99783" Site order(537..538,565..567,653..654) /site_type="other" /note="NAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(563..564,567) /site_type="other" /note="NADP ribose binding motif [chemical binding]" /db_xref="CDD:99783" CDS 1..686 /gene="FRE1" /locus_tag="YLR214W" /coded_by="NM_001182101.1:1..2061" /experiment="EXISTENCE:direct assay:GO:0000293 ferric-chelate reductase activity [PMID:8164662]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8164662|PMID:17507646]" /experiment="EXISTENCE:direct assay:GO:0006826 iron ion transport [PMID:8164662]" /experiment="EXISTENCE:direct assay:GO:0015677 copper ion import [PMID:7814363]" /note="Ferric reductase and cupric reductase; reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels" /db_xref="GeneID:850911" /db_xref="SGD:S000004204" ORIGIN 1 mvrtrvlfcl fisffatvqs satlistsci sqaalyqfgc sskskscyck ninwlgsvta 61 cayensksnk tldsalmkla sqcssikvyt ledmkniyln asnylrapek sdkktvvsqp 121 lmanetayhy yyeenygihl nlmrsqwcaw glvffwvavl taatilnilk rvfgkniman 181 svkksliyps vykdynertf ylwkrlpfnf ttrgkglvvl ifviltilsl sfghniklph 241 pydrprwrrs mafvsrradl maialfpvvy lfgirnnpfi pitglsfstf nfyhkwsayv 301 cfmlavvhsi vmtasgvkrg vfqslvrkfy frwgivatil msiiifqsek vfrnrgyeif 361 llihkamnim fiiamyyhch tlgwmgwiws magilcfdrf crivriimng glktatlstt 421 ddsnvikisv kkpkffkyqv gafaymyfls pksawfysfq shpftvlser hrdpnnpdql 481 tmyvkankgi trvllskvls apnhtvdcki flegpygvtv phiaklkrnl vgvaaglgva 541 aiyphfvecl rlpstdqlqh kfywivndls hlkwfenelq wlkekscevs viytgssved 601 tnsdestkgf ddkeeseitv eclnkrpdlk elvrseikls elennnitfy scgpatfndd 661 frnavvqgid sslkidvele eesftw // LOCUS NP_013316 360 aa linear PLN 30-JUN-2025 DEFINITION cell proliferation protein CDC123 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013316 VERSION NP_013316.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182102.1 REFERENCE 1 (residues 1 to 360) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 360) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 360) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 360) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09532. Method: conceptual translation. FEATURES Location/Qualifiers source 1..360 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..360 /product="cell proliferation protein CDC123" /calculated_mol_wt="41721" Region 27..328 /region_name="D123" /note="pfam07065" /db_xref="CDD:462079" CDS 1..360 /gene="CDC123" /locus_tag="YLR215C" /coded_by="NM_001182102.1:1..1083" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0002183 cytoplasmic translational initiation [PMID:23775072]" /experiment="EXISTENCE:mutant phenotype:GO:1905143 eukaryotic translation initiation factor 2 complex assembly [PMID:23775072|PMID:26211610]" /note="Assembly factor for the eIF2 translation initiation factor complex; regulates translational initiation; conserved residues of this ATP-Grasp protein that bind to ATP-Mg2+ in the pombe ortholog are required for complex assembly in budding yeast; interaction with eIF2 subunit Gcd11p facilitates complex assembly and activity; required for the START transition and timely progression through G2; regulated by nutrient availability; human ortholog complements the yeast mutant" /db_xref="GeneID:850912" /db_xref="SGD:S000004205" ORIGIN 1 mssqeyttfi dipvtraqve hcsysfwssl ypkyvpksiv lkslpkkfiq yleqdgiklp 61 qeensrsvyt eeiirnednd ysdweddedt atefvqevep lidfpelhqk lkdalnelga 121 vapklnwsap rdatwilpnn tmkcnevnel ylllnasnyi mhdlqrafkg cvdgddikgl 181 kfdlvlrqwc dmnpalefrv fvknahivga tqrdlnyydy ldelsdtfkd lideivhdvv 241 lpkfpdksfv ldvyiprpfn kifivdinpf arktdsllfs wneiaaiapp kndvedyelr 301 lvtrhntgrf askehsenhv pqdlveasln peaireltqk wkellsqqak eessdsenet // LOCUS NP_013317 371 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase CPR6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013317 VERSION NP_013317.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182103.1 REFERENCE 1 (residues 1 to 371) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 371) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 371) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 371) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09533. Method: conceptual translation. FEATURES Location/Qualifiers source 1..371 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..371 /product="peptidylprolyl isomerase CPR6" /EC_number="5.2.1.8" /calculated_mol_wt="41941" Region 4..173 /region_name="cyclophilin_ABH_like" /note="Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding...; cd01926" /db_xref="CDD:238907" Site order(63..64,69,120,122,130) /site_type="active" /db_xref="CDD:238907" Region 219..264 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(220,223..224,227..228,230,271,274..275,278..279, 281..282,309,312..313,316..317,320) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 269..303 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 275..>368 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" Region 308..334 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 342..368 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..371 /gene="CPR6" /locus_tag="YLR216C" /gene_synonym="CYP40" /coded_by="NM_001182103.1:1..1116" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:9191025|PMID:10942767]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095|PMID:9191025]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:9927435]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:10942767]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:25380751]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:10942767]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:9927435]" /note="Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; plays a role in determining prion variants; binds to Hsp82p and contributes to chaperone activity; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850914" /db_xref="SGD:S000004206" ORIGIN 1 mtrpktffdi siggkpqgri vfelyndivp ktaenflklc egnagmaktk pdvplsykgs 61 ifhrvikdfm cqfgdftnfn gtggesiyde kfedenftvk hdkpfllsma nagpntngsq 121 afitcvptph ldgkhvvfge viqgkrivrl ienqqcdqen nkplrdvkid dcgvlpddyq 181 vpenaeatpt deygdnyedv lkqdekvdlk nfdtvlkaie tvknigteqf kkqnysvale 241 kyvkcdkflk eyfpedleke qiekinqlkv siplniaica lklkdykqvl vassevlyae 301 aadekakaka lyrrglayyh vndtdmalnd lemattfqpn daailkaihn tklkrkqqne 361 kakkslskmf s // LOCUS NP_013319 150 aa linear PLN 30-JUN-2025 DEFINITION Coa4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013319 VERSION NP_013319.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182105.1 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09534. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..150 /product="Coa4p" /calculated_mol_wt="17121" Region 93..126 /region_name="CHCH" /note="CHCH domain; pfam06747" /db_xref="CDD:429096" CDS 1..150 /gene="COA4" /locus_tag="YLR218C" /gene_synonym="CMC3" /coded_by="NM_001182105.1:1..453" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:20624914|PMID:19703468]" /experiment="EXISTENCE:genetic interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:23198688|PMID:20624914]" /experiment="EXISTENCE:mutant phenotype:GO:0033108 mitochondrial respiratory chain complex assembly [PMID:19703468]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:20624914|PMID:23198688]" /note="Twin Cx(9)C protein involved in cytochrome c oxidase organization; organization includes assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors; mutation can be complemented by human COA4" /db_xref="GeneID:850915" /db_xref="SGD:S000004208" ORIGIN 1 mllfssffsh nkcpkqkkgp qplkvvkgts kscakqgkik gkeklwqakt grlvmsetge 61 tseyykqale eykevqeded pdvwdtrisk tgcyvenlal qlchaetgdw rqcfnemalf 121 rkcwekngnr ervstvdvdg ttskdsekkk // LOCUS NP_013320 728 aa linear PLN 30-JUN-2025 DEFINITION Msc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013320 VERSION NP_013320.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182106.1 REFERENCE 1 (residues 1 to 728) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 728) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 728) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 728) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 728) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 728) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 728) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 728) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 728) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09535. Method: conceptual translation. FEATURES Location/Qualifiers source 1..728 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..728 /product="Msc3p" /calculated_mol_wt="80399" Region 207..>384 /region_name="Mpp10" /note="U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and biogenesis]; COG5384" /db_xref="CDD:227674" Region 573..>718 /region_name="PHA03255" /note="BDLF3; Provisional" /db_xref="CDD:165513" CDS 1..728 /gene="MSC3" /locus_tag="YLR219W" /coded_by="NM_001182106.1:1..2187" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511544]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850916" /db_xref="SGD:S000004209" ORIGIN 1 mvfgftkrdr rvpdlsrydy yyqnhedynk spqlsaaaas aasaaspdrt nysrshslvs 61 hapsiprqrs svkspgrrls tssaapptsr aaakqysqkt yslrsqrsge yhlhppgytt 121 ngsrmnsmts ganvrrnygk nkstagnnnd sransitvkt tqvtdpsgrt qsitkktirk 181 ingyeyvett tttknlvplg dsqrhfdefs enymlqdddi leeqasdnih diieenetdn 241 ekpyspvses hlqddselnv ekpdfplgsy fhhkystdvm pleeesslsn fsdaldyipp 301 thqtsskyih nkrkqasttr rkkrppavkn aeaeakkplt eaemylkale vakrnvyhtd 361 aasdnasapl gsnksrksrm gqkmtlrsss dsptatanlv ksnvevqpkr ftssffsrnt 421 ksaphevhnh svsthfksnk avdpvpepks antgltdkem ydqalkiaqa ryynshgiqp 481 eavdnsttaa kprqvgvshl gstgsippne qhylgdseip vqsevheyep iplqktkttg 541 ssknkfktmf dkvlqfsqen ygyqhkkeqg eqtpvtrnae esfpaasise gvttakpssn 601 egvmtnpvvt dspsplqqqi dsttassngq sqgnvptsav asttrtrspe lqdnlkssss 661 llqdqtpqrq edatdpttss tnelsaaept mvtsthatkt iqaqtqdppt khkkssfftk 721 lfkkkssr // LOCUS NP_013321 322 aa linear PLN 30-JUN-2025 DEFINITION Ccc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013321 VERSION NP_013321.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182107.1 REFERENCE 1 (residues 1 to 322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 322) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09536. Method: conceptual translation. FEATURES Location/Qualifiers source 1..322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..322 /product="Ccc1p" /calculated_mol_wt="34119" Region 74..295 /region_name="CCC1" /note="cd02435" /db_xref="CDD:153126" CDS 1..322 /gene="CCC1" /locus_tag="YLR220W" /coded_by="NM_001182107.1:1..969" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:34203091|PMID:23708375]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11390404|PMID:26928762|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8866476]" /experiment="EXISTENCE:mutant phenotype:GO:0005384 manganese ion transmembrane transporter activity [PMID:11390404]" /experiment="EXISTENCE:mutant phenotype:GO:0006826 iron ion transport [PMID:11390404]" /experiment="EXISTENCE:mutant phenotype:GO:0006828 manganese ion transport [PMID:11390404]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:7941738]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:34203091|PMID:10713071]" /experiment="EXISTENCE:mutant phenotype:GO:0015093 ferrous iron transmembrane transporter activity [PMID:34203091|PMID:11390404]" /experiment="EXISTENCE:mutant phenotype:GO:0030026 intracellular manganese ion homeostasis [PMID:8866476]" /experiment="EXISTENCE:mutant phenotype:GO:1990461 detoxification of iron ion [PMID:34203091]" /note="Vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to vacuole decreases upon DNA replication stress; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:850917" /db_xref="SGD:S000004210" ORIGIN 1 msivalknav vtliqkakgs ggtselggse stpllrgsns nssrhdnlss sssdiiygrn 61 saqdlenspm svgkdnrngd ngsdnekanl gffqsvdprv isdliiglsd gltvpfalta 121 glsslgdakl vitggfaeli sgaismglgg ylgaksesdy yhaevkkekr kfydnsnlin 181 reiedillei npnfsdetiv sfikdlqrtp elmvdfiiry grgldepaen relisavtig 241 ggyllgglvp lvpyffvsdv gtgliysiiv mvvtlfwfgy vktklsmgsg sstskkvteg 301 vemvvvggva agaawffvkl lg // LOCUS NP_013322 220 aa linear PLN 30-JUN-2025 DEFINITION Rsa3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013322 VERSION NP_013322.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182108.1 REFERENCE 1 (residues 1 to 220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 220) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09537. Method: conceptual translation. FEATURES Location/Qualifiers source 1..220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..220 /product="Rsa3p" /calculated_mol_wt="24525" Region 160..205 /region_name="Rsa3" /note="Ribosome-assembly protein 3; pfam14615" /db_xref="CDD:434072" CDS 1..220 /gene="RSA3" /locus_tag="YLR221C" /coded_by="NM_001182108.1:1..663" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:15126390]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15126390]" /note="Protein with a likely role in ribosomal maturation; required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus" /db_xref="GeneID:850918" /db_xref="SGD:S000004211" ORIGIN 1 msagdisain iksvkknrrr kkrrtadvss sdssssdpss esekeeiqng aieehvgeng 61 ksdhvfskgn dedkqediai evsdveltde eskdlklnsk eviddltkis lskipeptks 121 qnkegfmnas kiaeniklar eeynelaenf vpkgkdktkl reeylnllfe nygddinrlr 181 aapdftnksl siladalqeg igmfdigele lvlknkemen // LOCUS NP_013323 817 aa linear PLN 30-JUN-2025 DEFINITION U3 snoRNA-associated protein UTP13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013323 VERSION NP_013323.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182109.1 REFERENCE 1 (residues 1 to 817) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 817) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 817) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 817) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09538. Method: conceptual translation. FEATURES Location/Qualifiers source 1..817 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..817 /product="U3 snoRNA-associated protein UTP13" /calculated_mol_wt="90901" Region <2..280 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 19..59 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 65..101 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 106..141 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 148..187 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 196..236 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 243..272 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 290..330 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 340..365 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 384..648 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(387,405,409,415..416,432..433,456,460,466..467, 489..490,507,512,518..519,532,549,554,560..561,573..574, 592,596,602..603,615..616,633,638,644..645) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 392..432 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 437..487 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 495..530 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 536..572 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 578..614 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 620..644 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 666..810 /region_name="Utp13" /note="Utp13 specific WD40 associated domain; pfam08625" /db_xref="CDD:462540" CDS 1..817 /gene="UTP13" /locus_tag="YLR222C" /coded_by="NM_001182109.1:1..2454" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034388 Pwp2p-containing subcomplex of 90S preribosome [PMID:15231838|PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /note="Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" /db_xref="GeneID:850919" /db_xref="SGD:S000004212" ORIGIN 1 mdlktsykgi slnpiyagss avatvsengk ilatpvldei niidltpgsr kilhkisned 61 eqeitalklt pdgqyltyvs qaqllkifhl ktgkvvrsmk isspsyilda dststllavg 121 gtdgsiivvd iengyithsf kghggtissl kfygqlnski wllasgdtng mvkvwdlvkr 181 kclhtlqeht savrgldiie vpdndepsln llsggrddii nlwdfnmkkk ckllktlpvn 241 qqvescgflk dgdgkriiyt aggdaifqli dsesgsvlkr tnkpieelfi igvlpilsns 301 qmflvlsdqt lqlinveedl kndedtiqvt ssiagnhgii admryvgpel nklalatnsp 361 slriipvpdl sgpeaslpld veiyeghedl lnsldatedg lwiataskdn taivwrynen 421 sckfdiyaky ighsaavtav glpnivskgy peflltasnd ltikkwiipk ptasmdvqii 481 kvseytrhah ekdinalsvs pndsifatas ydktckiwnl engeleatla nhkrglwdvs 541 fcqydkllat ssgdktvkiw sldtfsvmkt leghtnavqr csfinkqkql iscgadglik 601 iwdcssgecl ktldghnnrl walstmndgd mivsadadgv fqfwkdcteq eieeeqekak 661 lqveqeqslq nymskgdwtn afllamtldh pmrlfnvlkr algesrsrqd teegkievif 721 neeldqaisi lndeqlillm krcrdwntna kthtiaqrti rcilmhhnia klseipgmvk 781 ivdaiipytq rhftrvdnlv eqsyildyal vemdklf // LOCUS NP_013324 1085 aa linear PLN 30-JUN-2025 DEFINITION Ifh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013324 VERSION NP_013324.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182110.1 REFERENCE 1 (residues 1 to 1085) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1085) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1085) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1085) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1085) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1085) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1085) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1085) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1085) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09539. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1085 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1085 /product="Ifh1p" /calculated_mol_wt="122361" Region 678..788 /region_name="CRF1" /note="Transcription factor CRF1; pfam10380" /db_xref="CDD:371017" CDS 1..1085 /gene="IFH1" /locus_tag="YLR223C" /coded_by="NM_001182110.1:1..3258" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:15620355]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15466158|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15466158]" /experiment="EXISTENCE:direct assay:GO:0032545 CURI complex [PMID:17452446]" /experiment="EXISTENCE:genetic interaction:GO:0003713 transcription coactivator activity [PMID:15620355]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15620355]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:9755194]" /experiment="EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15616569]" /note="Coactivator, regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing; regulated by acetylation and phosphorylation at different growth states via TORC1 signaling; IFH1 has a paralog, CRF1, that arose from the whole genome duplication" /db_xref="GeneID:850920" /db_xref="SGD:S000004213" ORIGIN 1 magkksprks tinhsthsgk lpanikrlik kgesdtksrq spptlsttrp rrfsliysse 61 sslsdvsdsd knkstnphki krkaknisnn sqgkkskliq rqidnddegt essdyqavtd 121 geeseneeee seeeeeddde ddddddddgs dsdsdsetss ddenidfvkl taqrkkramk 181 alsamntnsn tlyssrensn knksvklspk keneeeqkee kekekeeqqk qqesnkkevn 241 gsgttttqqa lsfkfkkedd gisfgngneg ynedigeevl dlknkenngn eedkldskvm 301 lgnndelrfp nisesdesey didqdayfdv innedshgei gtdletgedd lpileeeeqn 361 ivselqndde lsfdgsihee gsdpvedaen kflqneynqe ngydeeddee deimsdfdmp 421 fyedpkfanl yyygdgsepk lslstslplm lndeklsklk kkeakkreqe erkqrrklyk 481 ktqkpstrtt snvdndeyif nvffqsdden sghkskkgrh ksgkshiehk nkgsnliksn 541 ddlepsthst vlnsgkydss ddeydnilld vahmpsddec sesetshdad tdeelralds 601 dsldigteld ddyeddddds svtnvfidid dldpdsfyfh ydsdgsssli ssnsdkensd 661 gskdckhdll etvvyvddes tdeddnlppp ssrsknigsk akeivssnvv glrppklgtw 721 etdnkpfsii dglstkslya liqehqqlre qhqraqtpdv kregssngnn gdeltlnell 781 nmseleddsp shtddmenny ndainskstn ghaadwyevp kvplsafrnk ginayeedey 841 mipansnrkv pigyignert rkkidkmkel qrkktekkrq lkkkkkllki rkqrqkaike 901 qetmnlqlgi ngheiignnn shsdintgtd fttnentpmn elpshapeda sliphnsdla 961 vdsntrknst ksvgldeihe ilgkdendll svgdingyda qeghviedtd adilasltap 1021 vqfdntlshe nsnsmwrrrq smveaaaenl rftknglfse saladiegim gndvnhsfef 1081 ndvlq // LOCUS NP_013325 369 aa linear PLN 30-JUN-2025 DEFINITION Ucc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013325 VERSION NP_013325.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182111.1 REFERENCE 1 (residues 1 to 369) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 369) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 369) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 369) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09540. Method: conceptual translation. FEATURES Location/Qualifiers source 1..369 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..369 /product="Ucc1p" /calculated_mol_wt="42623" CDS 1..369 /gene="UCC1" /locus_tag="YLR224W" /coded_by="NM_001182111.1:1..1110" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /experiment="EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:25982115]" /experiment="EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:25982115]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /note="F-box protein and component of SCF ubiquitin ligase complexes; involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; SCF-Ucc1 regulates level of Cit2 citrate synthase protein to maintain citrate homeostasis, acts as metabolic switch for glyoxylate cycle; UCC1 transcription is downregulated in cells grown on C2-compounds" /db_xref="GeneID:850921" /db_xref="SGD:S000004214" ORIGIN 1 mnqsdsslmd lpleihlsll eyvpnelrav nkyfyvlhnh sykekslawi aednyiwavv 61 khslclyvks ldplrqhare iiqetkepgf nvplcmtkyi adswyivyna lqypgkiinm 121 gwdkytksqd sngsdstsnf nsrpkertlm qsltalpvnf wsrrkdeptp vnvwfyvkna 181 hvaryipkii teigicnygp kqivasagyi nelitsegiy cvnlghlprl ydeqifegtg 241 tthlplelka idrtdsdvci ngdlvllgyd fipyqiskpw llfriepvns ieaifnysec 301 sfsyqfawsl aclqseekis fprdtiighg lpykpsklir ifvykhpeqk qdlgqeialp 361 nwntpylrr // LOCUS NP_013326 407 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR225C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013326 VERSION NP_013326.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182112.1 REFERENCE 1 (residues 1 to 407) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 407) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 407) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09541. Method: conceptual translation. FEATURES Location/Qualifiers source 1..407 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..407 /product="uncharacterized protein" /calculated_mol_wt="46292" Region 65..261 /region_name="Svf1" /note="Svf1-like N-terminal lipocalin domain; pfam08622" /db_xref="CDD:430110" Region 265..406 /region_name="Svf1_C" /note="Svf1-like C-terminal lipocalin-like domain; pfam17187" /db_xref="CDD:465375" CDS 1..407 /locus_tag="YLR225C" /coded_by="NM_001182112.1:1..1224" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YLR225C has a paralog, YDR222W, that arose from the whole genome duplication" /db_xref="GeneID:850922" /db_xref="SGD:S000004215" ORIGIN 1 mavaikkekt kfapvkevls ekdhanytkf qdtsklewfc rtsnhkkfks hsllkavrnp 61 tetrietqtl yftdltngkc gliqllyssv mggiykgfql nfkifkasse enseedidiw 121 esfkidnikd fdtlkvesdn vtfhfvplen ssssgfaqll ikidipkgst scllkdlkvd 181 itvnlqegfi inpdgsnyyl dksisleela krdssstsrk mirhvfvprg fcngtisykk 241 ndkpvkldlk dtpmlyldav qglipnkaas kwnflcfnge krsmmcieft ttkeygsttv 301 tiwavsdkdk ilevgssvnd havkfpstke dkqngwkypt sisfprgfee snlrlvnryd 361 imselpafir siaenlanmk pfiyqfcqks kfdddegvsi iestfin // LOCUS NP_013327 395 aa linear PLN 30-JUN-2025 DEFINITION Bur2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013327 VERSION NP_013327.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182113.1 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09542. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..395 /product="Bur2p" /calculated_mol_wt="45590" CDS 1..395 /gene="BUR2" /locus_tag="YLR226W" /gene_synonym="CST4" /coded_by="NM_001182113.1:1..1188" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:10982824]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:10982824]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:10982824]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:23109428]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:10982824]" /note="Cyclin for the Sgv1p (Bur1p) protein kinase; subunit of the CDK-cyclin BUR kinase complex with Sgv1p (Bur1p); regulates Set2p-dependent H3K36 trimethylation; regulates transcriptional elongation through the phosphorylation of the carboxy-terminal domain (CTD) of Rpo21p; involved in the recruitment of Spt6p to the CTD at the onset of transcription; regulates telomere elongation" /db_xref="GeneID:850923" /db_xref="SGD:S000004216" ORIGIN 1 msatsssgdv kkfqavpkpt snaspppass gfnartlwpd lietpenqwv feckdiieki 61 gtngpiavei kknmekclmy fytlkkklnl fdhtytasci lfyrywfiyg iptaitecih 121 isqgilvtac ktmennrpie ayikatcefl mqnipslksr tnidklkwef rdklvtnekk 181 ilclfgfdln isnpkeliee vfsgyyrfnr dhnlpenfkk afpkilqesr nfmvqavtqp 241 vsllcdgytf ivlsliycgl eykklvdkdf rypknffkdr fpievtpenf aniftdykll 301 eenffnlksn kgaklqidss midsvidesg dvenevseis dpfnyeliks gevkeeflnh 361 ietrvkdlld kakqesmkrk akdpirtpda kkpki // LOCUS NP_013328 493 aa linear PLN 30-JUN-2025 DEFINITION Ady4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013328 VERSION NP_013328.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182114.1 REFERENCE 1 (residues 1 to 493) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 493) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 493) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 493) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09543. Method: conceptual translation. FEATURES Location/Qualifiers source 1..493 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..493 /product="Ady4p" /calculated_mol_wt="57702" CDS 1..493 /gene="ADY4" /locus_tag="YLR227C" /coded_by="NM_001182114.1:1..1482" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12796288]" /experiment="EXISTENCE:direct assay:GO:0035974 meiotic spindle pole body [PMID:12796288]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12796288]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0035974 meiotic spindle pole body [PMID:12796288]" /note="Structural component of the meiotic outer plaque; outer plaque is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane" /db_xref="GeneID:850924" /db_xref="SGD:S000004217" ORIGIN 1 mnkdvdyqtf kkslrkefkk avktilnlqa yngdlirdfl alyipyhvvf ynlsimkkgs 61 plriqtnnll kealakilnf nlamgpkhii kimkkdkadp etmnklklvl yiklfqgvfg 121 hvdknynlaf qsfrwclqfi ayskrtrlfa siadeqigaf yelcelfism lcchcflidl 181 kenealvgnn lknfikrqnp nyshgfdlne etkslqwhws ldevdvieal ycvafdamdk 241 itlkfskvne nfvfsqffqy caeieemlai lrgkiwecec dvfgprigll vdsnhmneti 301 qknilsitfk lkndpqiicc lnkileglll ssgvqfkviq ffyvlklyym qdneytfeas 361 semdkltiec lciieniida cdnpdevtdy qlpkvlltam egkllvaeki sedndcsesl 421 ddyhprtyqf rhpriiidkm ktklkqklrf dspkdpetdd hwieywkycy qdnignlpdi 481 lsriyqtftd psn // LOCUS NP_058172 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058172 VERSION NP_058172.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184407.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09545. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..440 /product="gag protein" /calculated_mol_wt="48862" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YLR227W-A" /coded_by="NM_001184407.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:850926" /db_xref="SGD:S000007375" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_058171 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058171 VERSION NP_058171.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184408.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09544. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198275" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YLR227W-B" /coded_by="join(NM_001184408.2:1..1305, NM_001184408.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:850927" /db_xref="SGD:S000007376" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivqy gdfywvskry llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksas qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskpisei nlraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysnnetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdpppep 1141 ptelsdsfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaaak avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmntwdtd kyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydtgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 hyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniflln gkviggkstk asltctstte aeihavseai pllnnlshlv qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_013329 814 aa linear PLN 30-JUN-2025 DEFINITION Ecm22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013329 VERSION NP_013329.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182115.1 REFERENCE 1 (residues 1 to 814) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 814) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 814) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 814) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 814) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 814) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 814) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 814) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 814) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09546. Method: conceptual translation. FEATURES Location/Qualifiers source 1..814 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..814 /product="Ecm22p" /calculated_mol_wt="89155" Region 39..80 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(39,43,48..51,53,56,66) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(44,47,54,61,64,71) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 508..>638 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cl23766" /db_xref="CDD:419994" CDS 1..814 /gene="ECM22" /locus_tag="YLR228C" /coded_by="NM_001182115.1:1..2445" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11533229]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11533229]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:18675371]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:18675371]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:26448198|PMID:11208779]" /experiment="EXISTENCE:genetic interaction:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:26448198]" /experiment="EXISTENCE:genetic interaction:GO:2000911 positive regulation of sterol import [PMID:11208779]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:16055745]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:26448198|PMID:11533229|PMID:16055745]" /experiment="EXISTENCE:mutant phenotype:GO:0070452 positive regulation of ergosterol biosynthetic process [PMID:11533229|PMID:16055745]" /experiment="EXISTENCE:mutant phenotype:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:26448198]" /note="Sterol regulatory element binding protein; regulates transcription of sterol biosynthetic genes upon sterol depletion, after relocating from intracellular membranes to perinuclear foci; redundant activator of filamentation with UPC2, up-regulating the expression of genes involved in filamentous growth; contains Zn[2]-Cys[6] binuclear cluster; ECM22 has a paralog, UPC2, that arose from the whole genome duplication" /db_xref="GeneID:850928" /db_xref="SGD:S000004218" ORIGIN 1 mtsddgnagq erekdaelie vggkkvskts tgkrkfhnks ktgcdnckrr rvkcdegkpf 61 ckkctnmkld cvyspiqprr rkdsssskfa savhdrvgkk nlsdnaimlq qqqqqlhhqq 121 eqqfrqqqqv qlqqqllphv gtdeqsnspn svppsvsnnm enlllphlla slvnntsnst 181 nssangaeah nnitqtapss minnnhpnma lpgnsplsip itpsfqstam nlssslngll 241 spgrlnsvtn glqqpqlqqq nqqipqqqgt qspfsnipfd qlaqlnkmgl nfnmksfntl 301 fpygaangma sefqelfglg kfatsnnrai kvstaeeala nmqqeqedkn kqftknpldn 361 tktdavnsgn nplngnenkv tasdilshnk nliidntglt ispphtlskp sidqniasps 421 tgvsnvtstk sllsipdnrt algnsptlkt spmgdllsns ealsprssns htqqqssphs 481 nassasrlvp elvglsrksn lnlidlklfh hyctdvwhti teagisgpev wstyipdlaf 541 hfpflmhtil afsathlsrt eagldnyvss hrlealrllr eavleisddn tdalvasali 601 lildslanas sssptawifh vkgavtilta vwplsetskf ynlisvdlsd lgeavinqsn 661 hnndndnsnn gdgnnnntis elvcfdesia dlypveidsp ylitlayldk lhreknqldf 721 mlrvfsfpal ldrtflallm tgdlgamrim rsyytllrgy tteikdkvwf ldsvsqvlpq 781 dvdeysgggg mhmmldflgg glpsmtttnf safm // LOCUS NP_013330 191 aa linear PLN 30-JUN-2025 DEFINITION Rho family GTPase CDC42 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013330 VERSION NP_013330.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182116.1 REFERENCE 1 (residues 1 to 191) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 191) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 191) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 191) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09547. Method: conceptual translation. FEATURES Location/Qualifiers source 1..191 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..191 /product="Rho family GTPase CDC42" /EC_number="3.6.5.2" /calculated_mol_wt="21192" Region 3..177 /region_name="Cdc42" /note="cell division cycle 42 (Cdc42) is a small GTPase of the Rho family; cd01874" /db_xref="CDD:206664" Site order(3,5,31..32,35..36,38..39,41,43,52,56..61,64..67, 70..71,73..74,103..104) /site_type="other" /note="GEF (guanine nucleotide exchange factor) interaction site [polypeptide binding]" /db_xref="CDD:206664" Site order(4,7..13,16,20..21,23,28,30..48,52..53,57..63,67..68, 70,116,120,166,170,173..174,177) /site_type="active" /note="ACK tyrosine kinase interaction site [active]" /db_xref="CDD:206664" Site 10..17 /site_type="other" /note="G1 box" /db_xref="CDD:206664" Site order(13..18,29,32..33,35,57..58,60,116,118,159..160) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206664" Site order(20..21,36,38,40,46,67,70,173..174,177) /site_type="active" /note="CRIB effector interaction site [active]" /db_xref="CDD:206664" Site order(23..25,37,39..41,43,45..47,64,166) /site_type="active" /note="Par6 cell polarity protein interaction site [active]" /db_xref="CDD:206664" Site 25..40 /site_type="other" /note="Switch I region" /db_xref="CDD:206664" Site order(32,34,36..37,61..64,67,70) /site_type="other" /note="GAP (GTPase-activating protein) interaction site [polypeptide binding]" /db_xref="CDD:206664" Site order(35..36,59,64,66..67,69..70,73,103..104,106) /site_type="other" /note="GDI (guanine nucleotide dissociation inhibitor) interaction site [polypeptide binding]" /db_xref="CDD:206664" Site 35 /site_type="other" /note="G2 box" /db_xref="CDD:206664" Site 57..60 /site_type="other" /note="G3 box" /db_xref="CDD:206664" Site 59..77 /site_type="other" /note="Switch II region" /db_xref="CDD:206664" Site 115..118 /site_type="other" /note="G4 box" /db_xref="CDD:206664" Site 158..160 /site_type="other" /note="G5 box" /db_xref="CDD:206664" CDS 1..191 /gene="CDC42" /locus_tag="YLR229C" /coded_by="NM_001182116.1:1..576" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12455994|PMID:8167411]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:12455994|PMID:11598008]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11591390]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:32556066]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8167411|PMID:12455994]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:8167411|PMID:12455994]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12455994]" /experiment="EXISTENCE:direct assay:GO:0005940 septin ring [PMID:23906065]" /experiment="EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:12455994]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:22832273|PMID:8167411]" /experiment="EXISTENCE:direct assay:GO:0071763 nuclear membrane organization [PMID:32556066]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0045921 positive regulation of exocytosis [PMID:19955214]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:22323294]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:11003652]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:10066831]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:12234925]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10066831]" /experiment="EXISTENCE:mutant phenotype:GO:0007119 budding cell isotropic bud growth [PMID:10066831]" /experiment="EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:1904541]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:23468594]" /experiment="EXISTENCE:mutant phenotype:GO:0031106 septin ring organization [PMID:16371506|PMID:14517318]" /experiment="EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:11598008]" /experiment="EXISTENCE:mutant phenotype:GO:0045921 positive regulation of exocytosis [PMID:11595741]" /experiment="EXISTENCE:mutant phenotype:GO:0060178 regulation of exocyst localization [PMID:11595741]" /experiment="EXISTENCE:mutant phenotype:GO:2000222 positive regulation of pseudohyphal growth [PMID:8643578]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9367979|PMID:9367980]" /experiment="EXISTENCE:physical interaction:GO:0045921 positive regulation of exocytosis [PMID:19955214]" /note="Small rho-like GTPase; essential for establishment and maintenance of cell polarity; plays a role late in cell fusion via activation of key cell fusion regulator Fus2p; acts with ESCRT proteins at sites of nuclear envelope and ER fission; mutants have defects in the organization of actin and septins; human homolog CDC42 can complement yeast cdc42 mutant" /db_xref="GeneID:850930" /db_xref="SGD:S000004219" ORIGIN 1 mqtlkcvvvg dgavgktcll isyttnqfpa dyvptvfdny avtvmigdep ytlglfdtag 61 qedydrlrpl sypstdvflv cfsvisppsf envkekwfpe vhhhcpgvpc lvvgtqidlr 121 ddkviieklq rqrlrpitse qgsrlarelk avkyvecsal tqrglknvfd eaivaalepp 181 vikkskkcai l // LOCUS NP_013332 453 aa linear PLN 30-JUN-2025 DEFINITION kynureninase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013332 VERSION NP_013332.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182118.1 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09548. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..453 /product="kynureninase" /EC_number="3.7.1.3" /calculated_mol_wt="50901" Region 4..451 /region_name="kynureninase" /note="TIGR01814" /db_xref="CDD:130873" CDS 1..453 /gene="BNA5" /locus_tag="YLR231C" /coded_by="NM_001182118.1:1..1362" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan [PMID:12062417]" /experiment="EXISTENCE:mutant phenotype:GO:0030429 kynureninase activity [PMID:12062417]" /note="Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p" /db_xref="GeneID:850933" /db_xref="SGD:S000004221" ORIGIN 1 mekaleldge ypeslrdefn iptfksmgls sddkpvtylc gnslglmpks trnsinaeld 61 awsdcavesh fkhpeeargk vpwvsidlpi lpllapivga qenevavmns ltanlnslli 121 tfykptekrf kilfekgsfp sdyyafynqc kihgisepen vfiqiepreg etyirtqdil 181 dtievnqdel alvclsgvqy ytgqyfdigr itsfahqfpd ilvgwdlaha vgnvplqlhd 241 wgvdfacwcs ykylnagpgg igglfvhskh tkpdpakesl prlagwwgnd pakrfqmlev 301 fepipgalgf rqsnpsvidt valrsslelf akfnginevr krsllltnym telleaskyy 361 khplrieklp cfftiltpts tdeehgaqls lyfdsdtgke dimpkvfqyl hdhgvigdar 421 rpnvirlapa plyntfsdvy iavnalneam dkl // LOCUS NP_013334 699 aa linear PLN 30-JUN-2025 DEFINITION Est1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013334 VERSION NP_013334.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182120.1 REFERENCE 1 (residues 1 to 699) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 699) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 699) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 699) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 699) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09549. Method: conceptual translation. FEATURES Location/Qualifiers source 1..699 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..699 /product="Est1p" /calculated_mol_wt="81669" Region 81..209 /region_name="EST1" /note="Telomerase activating protein Est1; pfam10374" /db_xref="CDD:463062" Region 224..508 /region_name="EST1_DNA_bind" /note="Est1 DNA/RNA binding domain; pfam10373" /db_xref="CDD:431239" CDS 1..699 /gene="EST1" /locus_tag="YLR233C" /coded_by="NM_001182120.1:1..2100" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:8985179]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12101098]" /experiment="EXISTENCE:direct assay:GO:0005697 telomerase holoenzyme complex [PMID:10898986]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12101098]" /experiment="EXISTENCE:direct assay:GO:0007004 telomere maintenance via telomerase [PMID:10898986]" /experiment="EXISTENCE:direct assay:GO:0032210 regulation of telomere maintenance via telomerase [PMID:27659693]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:17656141]" /experiment="EXISTENCE:direct assay:GO:0071919 G-quadruplex DNA formation [PMID:20098422|PMID:23376615]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:2655926]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:8978029|PMID:10898986]" /experiment="EXISTENCE:physical interaction:GO:0003723 RNA binding [PMID:12414733]" /note="TLC1 RNA-associated factor involved in telomere length regulation; recruitment subunit of telomerase; has G-quadruplex promoting activity required for telomere elongation; role in activating telomere-bound Est2p-TLC1-RNA; EST1 has a paralog, EBS1, that arose from the whole genome duplication" /db_xref="GeneID:850934" /db_xref="SGD:S000004223" ORIGIN 1 mdneevneec mrlffknara hldkhltsrl tcdenayitf rcfldgihrk strfleelll 61 kqenmyhnnn yerindsvip lvlkllwlqi heptlqwfeh wfhdimrlsn rrkfrvfrif 121 qkkmiqffki thryyydiie hlcakydmns visnalfakl nlmqytdgls thekiilnts 181 npltfsivis lqrcvinlgs thfyktllnk psnkpksveg feksirylni aslylpavgd 241 tyfqrakiyl itgkfslyff elvrgalvri pskcalnnlk dfiltpdfpe rrrlmkklai 301 lvskdlkgek sffegqivlq flsivehtlv pqswnasras ncwllkehlq maalkyhsgn 361 invilenlaa tmgsfdlmft trkskeqknk lkyadlserq vffldlsfdf ianiidvvik 421 pswqknmedf rylaiirllm cwiksyrsil qythrhrkfc tsfalllndl insplncsgn 481 iyshrpkrsy lfrediifre fscinfaltd fnddyvydsp dminniigcp tltkvlspke 541 ecvlrirsii fsgmkflekn dtgviwnask ykfdlispni kikrqialse isskinvktq 601 qervvssrkv eakrdeqqrk ragkiavtel ekqfanvrrt kklsplpekd gvsselvkha 661 asrgrktitg plssdflsyp deaidadedi tvqvpdtpt // LOCUS NP_013335 656 aa linear PLN 30-JUN-2025 DEFINITION DNA topoisomerase 3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013335 VERSION NP_013335.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182121.1 REFERENCE 1 (residues 1 to 656) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 656) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 656) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 656) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09550. Method: conceptual translation. FEATURES Location/Qualifiers source 1..656 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..656 /product="DNA topoisomerase 3" /EC_number="5.6.2.1" /calculated_mol_wt="74240" Region 2..168 /region_name="TOPRIM_TopoIA_TopoIII" /note="The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA...; cd03362" /db_xref="CDD:173782" Site order(8..9,12,120,122,124) /site_type="active" /db_xref="CDD:173782" Site order(15,121,123,130..131,133..134) /site_type="other" /note="putative interdomain interaction site [polypeptide binding]" /db_xref="CDD:173782" Site order(120,122) /site_type="other" /note="putative metal-binding site [ion binding]" /db_xref="CDD:173782" Site 123 /site_type="other" /note="putative nucleotide binding site [chemical binding]" /db_xref="CDD:173782" Region 173..635 /region_name="TOP1Ac" /note="DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; cd00186" /db_xref="CDD:238110" Site order(173..200,229..249) /site_type="active" /note="domain I [active]" /db_xref="CDD:238110" Site order(182..183,186,190,194,346,350,358,549..550,553..554, 556,560..561) /site_type="DNA binding" /note="DNA binding groove [nucleotide binding]" /db_xref="CDD:238110" Site order(240,244,589) /site_type="other" /note="phosphate binding site [ion binding]" /db_xref="CDD:238110" Site order(254..261,302..316,459..473,475..493,516..526) /site_type="active" /note="domain II [active]" /db_xref="CDD:238110" Site order(317..323,325..380,422..428,438..458) /site_type="active" /note="domain III [active]" /db_xref="CDD:238110" Site order(328,332..334,423,444,447,451,547,549,575) /site_type="other" /note="nucleotide binding site [chemical binding]" /db_xref="CDD:238110" Site order(356,358,423) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:238110" Site order(527..567,575..589,597..635) /site_type="active" /note="domain IV [active]" /db_xref="CDD:238110" CDS 1..656 /gene="TOP3" /locus_tag="YLR234W" /gene_synonym="EDR1" /coded_by="NM_001182121.1:1..1971" /experiment="EXISTENCE:direct assay:GO:0003916 DNA topoisomerase activity [PMID:22885009]" /experiment="EXISTENCE:direct assay:GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity [PMID:1324925]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]" /experiment="EXISTENCE:direct assay:GO:0031422 RecQ family helicase-topoisomerase III complex [PMID:15899853]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:16546998]" /experiment="EXISTENCE:mutant phenotype:GO:0000018 regulation of DNA recombination [PMID:1328869]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:7708702]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:17571075]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:1328869]" /experiment="EXISTENCE:physical interaction:GO:0031422 RecQ family helicase-topoisomerase III complex [PMID:15889139]" /note="DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity is stimulated by RPA and Sgs1p-Top3p-Rmi1p; involved in telomere stability and regulation of mitotic recombination" /db_xref="GeneID:850935" /db_xref="SGD:S000004224" ORIGIN 1 mkvlcvaekn siakavsqil gggrstsrds gymyvknydf mfsgfpfarn gancevtmts 61 vaghltgidf shdshgwgkc aiqelfdapl neimnnnqkk iasnikrear nadylmiwtd 121 cdregeyigw eiwqeakrgn rliqndqvyr avfshlerqh ilnaarnpsr ldmksvhavg 181 trieidlrag vtftrlltet lrnklrnqat mtkdgakhrg gnkndsqvvs ygtcqfptlg 241 fvvdrferir nfvpeefwyi qlvvenkdng gtttfqwdrg hlfdrlsvlt fyetcietag 301 nvaqvvdlks kpttkyrplp lttvelqknc arylrlnakq sldaaeklyq kgfisyprte 361 tdtfphamdl kslvekqaql dqlaaggrta wasyaasllq pentsnnnkf kfprsgshdd 421 kahppihpiv slgpeanvsp verrvyeyva rhflaccsed akgqsmtlvl dwaverfsas 481 glvvlernfl dvypwarwet tkqlprlemn alvdiakaem kagttappkp mteselillm 541 dtngigtdat iaehidkiqv rnyvrsekvg ketylqpttl gvslvhgfea igledsfakp 601 fqrremeqdl kkiceghask tdvvkdivek yrkywhktna ckntllqvyd rvkasm // LOCUS NP_001335797 107 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR236C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335797 VERSION NP_001335797.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348857.1 REFERENCE 1 (residues 1 to 107) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 107) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 107) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 107) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80317. Method: conceptual translation. FEATURES Location/Qualifiers source 1..107 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..107 /product="uncharacterized protein" /calculated_mol_wt="11465" CDS 1..107 /locus_tag="YLR236C" /coded_by="NM_001348857.1:1..324" /note="hypothetical protein; conserved across S. cerevisiae strains; overlaps ORF YLR235C" /db_xref="GeneID:850937" /db_xref="SGD:S000004226" ORIGIN 1 mhticlrspi dessplpyks irqplenahs cqalcslmav lcasaahrls etfpmrlvva 61 reyanwgafq haftrragas vaatsawfda vaagtenahm qsaescn // LOCUS NP_013338 598 aa linear PLN 30-JUN-2025 DEFINITION thiamine transporter THI7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013338 VERSION NP_013338.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182124.1 REFERENCE 1 (residues 1 to 598) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 598) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 598) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 598) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09551. Method: conceptual translation. FEATURES Location/Qualifiers source 1..598 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..598 /product="thiamine transporter THI7" /calculated_mol_wt="66773" Region 27..505 /region_name="SLC-NCS1sbd_NRT1-like" /note="nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain; cd11482" /db_xref="CDD:271375" Site order(53,56,342,345..346) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271375" Site order(57,133,137,254..255,257,347,351) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:271375" CDS 1..598 /gene="THI7" /locus_tag="YLR237W" /gene_synonym="THI10" /coded_by="NM_001182124.1:1..1797" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16850348|PMID:9235906]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015234 thiamine transmembrane transporter activity [PMID:9358046]" /experiment="EXISTENCE:genetic interaction:GO:0015888 thiamine transport [PMID:9358046|PMID:16850348]" /experiment="EXISTENCE:genetic interaction:GO:1903088 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport [PMID:24778186]" /experiment="EXISTENCE:genetic interaction:GO:1903089 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity [PMID:24778186]" /experiment="EXISTENCE:mutant phenotype:GO:0015234 thiamine transmembrane transporter activity [PMID:9235906|PMID:9358046]" /experiment="EXISTENCE:mutant phenotype:GO:0015888 thiamine transport [PMID:9358046|PMID:16850348|PMID:9235906]" /note="Plasma membrane transporter responsible for the uptake of thiamine; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia" /db_xref="GeneID:850938" /db_xref="SGD:S000004227" ORIGIN 1 msfgskvsra lrfleipvkd rasvsflknp dlqpiksanq twgfwsnfay wgvmsfsvgt 61 wmsassalgv glsypetigt fivgdvltii ftlanscpgy dwkvgftlaq rfvfgiygsa 121 fgiiirilms ivnygsnawv gglcinmild swshhylhlp ntlsskvamt tkeligfiif 181 hvltafcylm kpyhmnyili wscvatffsm lgmviylakq ahgvgelfts tkstatgstk 241 awawvymisy wfgsvspgst nqsdysrfgs snwaiwagti callipttli pvfgvigast 301 cdklygeqyw mpmdifnhwl ttnysagara gaffcglsfv lsqmsytisn cgfasgmdla 361 gllpkyvdik rgalfaacvs waclpwnfyn ssstfltvms sfgvvmtpii svmicdnfli 421 rkrqysitna filkgeyyft kgvnwraiva wvcgmtpglp giawevnndy fhntgivnff 481 ygdsffsfli sffvywglcl lfpfkitvkh ddkdyygaft deearkkgmv pyseiseeei 541 raytlgegyt tgheyrpegs ddeipelvkt ssentnefei vhhknnekqs stasekaa // LOCUS NP_013339 478 aa linear PLN 30-JUN-2025 DEFINITION Far10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013339 VERSION NP_013339.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182125.1 REFERENCE 1 (residues 1 to 478) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 478) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 478) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09552. Method: conceptual translation. FEATURES Location/Qualifiers source 1..478 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..478 /product="Far10p" /calculated_mol_wt="53961" Region 73..210 /region_name="FHA_VPS64-like" /note="forkhead associated (FHA) domain found in Saccharomyces cerevisiae vacuolar protein sorting-associated protein 64 (VPS64) and similar proteins; cd22695" /db_xref="CDD:438747" Site order(102..103,143..144,146,165,167..168) /site_type="other" /note="putative phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438747" Region <316..432 /region_name="PLN00040" /note="Protein MAK16 homolog; Provisional" /db_xref="CDD:215038" CDS 1..478 /gene="FAR10" /locus_tag="YLR238W" /coded_by="NM_001182125.1:1..1437" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12514182|PMID:23625923]" /experiment="EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]" /note="Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate; FAR10 has a paralog, VPS64, that arose from the whole genome duplication" /db_xref="GeneID:850939" /db_xref="SGD:S000004228" ORIGIN 1 mtgpgpeink eehpsspgkk qitynsipkn anlidgstns skrpiekydk riadptksyf 61 phsisrtprr kytyilvlts lngtfeskhv vipfkpdglk lgrpvansns ssssslrggk 121 rvdshtfsqv rsdngnfdsr vlsrnhalls cdpltgkvyi rdlkssngtf ingqrigsnd 181 veikvgdvid lgtdidtkie hrkisatvee lfvqpllesp ifenedsddc htitekeeaa 241 aitshiygds nnleleevil gsdteilsgi finncigtsp tlsniiktla meipfskcdn 301 fklqsmenfl inytthleyt nkllvekndq qlvklqnglr rklsgkyeki ieqnrnqvkq 361 lerdhmffkk sfevkkrrnn ekqksmerei edlktrleve ryknsqmmkk nkqkeqelst 421 askkkttehd trgvpgmnpk gtdkfsiknt lcnhftlltf gtisigiiai vfkilspn // LOCUS NP_013340 328 aa linear PLN 30-JUN-2025 DEFINITION lipoyl(octanoyl) transferase LIP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013340 VERSION NP_013340.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182126.1 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09553. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..328 /product="lipoyl(octanoyl) transferase LIP2" /EC_number="2.3.1.181" /calculated_mol_wt="37106" Region 90..309 /region_name="BPL_LplA_LipB" /note="biotin-lipoate ligase family; cl14057" /db_xref="CDD:449326" Site order(162,164..167,169,177,238,241..243,254..256) /site_type="active" /db_xref="CDD:319743" CDS 1..328 /gene="LIP2" /locus_tag="YLR239C" /coded_by="NM_001182126.1:1..987" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0009249 protein lipoylation [PMID:19570983|PMID:11356580]" /experiment="EXISTENCE:mutant phenotype:GO:0016874 ligase activity [PMID:11356580]" /note="Lipoyl ligase; involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups" /db_xref="GeneID:850940" /db_xref="SGD:S000004229" ORIGIN 1 msrcirqsvc tnfnvcrrqc fstyasalke mthpikpsaq tlrhlqftqr ipfqkgleiq 61 etlvranldi kdiqskierk liqldeeykg tatindnekr ildkvmamkp npiiltfefe 121 ptytggkrik ktmtpdqiaa yesfipetqk dnprpkfvqv erggqvtfhg pgqiviyiil 181 dlktfqsfpa kclvscieqa tirtlkntkm cddtdkplnl damttkdtgv wvengkkkva 241 svgihvrrsi tshgvainvn tdlsymnsfe mcglkntltt simeqrpdav vnvqsvaisf 301 vkemtkllgi ktlermqidd vnilkknp // LOCUS NP_013341 875 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol 3-kinase VPS34 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013341 VERSION NP_013341.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182127.1 REFERENCE 1 (residues 1 to 875) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 875) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 875) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 875) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09554. Method: conceptual translation. FEATURES Location/Qualifiers source 1..875 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..875 /product="phosphatidylinositol 3-kinase VPS34" /EC_number="2.7.1.137" /calculated_mol_wt="100791" Region <1..872 /region_name="TEL1" /note="Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032" /db_xref="CDD:227365" Region 528..871 /region_name="PI3Kc_III" /note="Catalytic domain of Class III Phosphoinositide 3-kinase; cd00896" /db_xref="CDD:270628" Site order(600,602..604,606,622,624,627,658,670..673,677,680, 736,738,748..749) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270628" Site 728..736 /site_type="active" /note="catalytic loop [active]" /db_xref="CDD:270628" Site 749..768 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270628" CDS 1..875 /gene="VPS34" /locus_tag="YLR240W" /gene_synonym="END12; PEP15; STT8; VPL7; VPS7; VPT29" /coded_by="NM_001182127.1:1..2628" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347|PMID:16421251]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:16421251]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:7989323]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:16421251]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:21121900]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016303 1-phosphatidylinositol-3-kinase activity [PMID:8385367|PMID:7989323]" /experiment="EXISTENCE:direct assay:GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I [PMID:11157979]" /experiment="EXISTENCE:direct assay:GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II [PMID:11157979]" /experiment="EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:8385367|PMID:7989323]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:23335340]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:21121900]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:32788210]" /experiment="EXISTENCE:mutant phenotype:GO:0016303 1-phosphatidylinositol-3-kinase activity [PMID:8385367]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:23335340]" /experiment="EXISTENCE:mutant phenotype:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:8385367]" /experiment="EXISTENCE:mutant phenotype:GO:0051365 cellular response to potassium ion starvation [PMID:32788210]" /note="Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery" /db_xref="GeneID:850941" /db_xref="SGD:S000004230" ORIGIN 1 mslnnitfcv sqdldvplkv kiksleghkp llkpsqkiln pelmligsnv fpssdlivsl 61 qvfdkernrn ltlpiytpyi pfrnsrtwdy wltlpirikq ltfsshlrii lweyngskqi 121 pffnletsif nlkdctlkrg feslkfrydv idhcevvtdn kdqenlnkyf qgeftrlpwl 181 deitisklrk qrenrtwpqg tfvlnlefpm lelpvvfier eimntqmnip tlknnpglst 241 dlrepnrndp qikislgdky hstlkfydpd qpnndpieek yrrleraskn anldkqvkpd 301 ikkrdylnki inyppgtklt ahekgsiwky ryylmnnkka ltkllqstnl reeservevl 361 elmdswaeid iddalellgs tfknlsvrsy avnrlkkasd kelelyllql veavcfenls 421 tfsdksnsef tivdavssqk lsgdsmllst shanqkllks issesetsgt eslpivispl 481 aeflirralv nprlgsffyw ylksesedkp yldqilssfw srldkksrni lndqvrlinv 541 lreccetikr lkdttakkme llvhlletkv rplvkvrpia lpldpdvlic dvcpetskvf 601 ksslsplkit fkttlnqpyh lmfkvgddlr qdqlvvqiis lmnellknen vdlkltpyki 661 latgpqegai efipndtlas ilskyhgilg ylklhypden atlgvqgwvl dnfvkscagy 721 cvityilgvg drhldnllvt pdghffhadf gyilgqdpkp fpplmklppq iieafggaes 781 snydkfrsyc fvaysilrrn aglilnlfel mktsnipdir idpngailrv rerfnlnmse 841 edatvhfqnl indsvnallp ividhlhnla qywrt // LOCUS NP_013342 782 aa linear PLN 30-JUN-2025 DEFINITION Csc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013342 VERSION NP_013342.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182128.1 REFERENCE 1 (residues 1 to 782) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 782) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 782) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 782) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09555. Method: conceptual translation. FEATURES Location/Qualifiers source 1..782 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..782 /product="Csc1p" /calculated_mol_wt="89213" Region 1..782 /region_name="COG5594" /note="Uncharacterized integral membrane protein [Function unknown]" /db_xref="CDD:227881" CDS 1..782 /gene="CSC1" /locus_tag="YLR241W" /coded_by="NM_001182128.1:1..2349" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0005227 calcium-activated cation channel activity [PMID:24503647]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006812 monoatomic cation transport [PMID:24503647]" /note="Calcium permeable gated cation channel; functions as an osmosensitive, calcium-permeable cation channel when expressed in a heterologous system; may be involved in detoxification; similar to Arabidopsis CSC1" /db_xref="GeneID:850942" /db_xref="SGD:S000004231" ORIGIN 1 mtsyierlks aasyldtvpd ehhdfrkpta kvvttqltia tslgifalls fsillkkwpr 61 lyasrrykdd gnlrlpswnq sslfgwltvl ykirdeqile yagldayvfl sffkmcikll 121 sifcffsvcv ispvryhftg kiddgndddd sesslihlvk rivegsgdgd nhsapertnv 181 ylwmyvlfty fftfiaikma vaetkhvvst rqaylgkqnt itdrtirlsg ipielrdsea 241 lktrieqlki gtvssiticr ewgplnklfh crkkilknle lkysecprel rtrqpyseny 301 hllgneqsga vthgenvpss nnndedtily sqislgerpk mkigyrgifg kevdaieyle 361 qqlkfidaei iearkqhysa tptafvtmds vanaqmaaqa vldprvhyfi trlapaphdi 421 kwdhvclsrk drltkvystt vfiglsslfl vipvsylatl lnlktlskfw psvgqllkdh 481 qwaanivtgl lptylftlln fgipyfyeyl tsyqglvsys eeeislvskn ffyifvnlfl 541 vftlagtasn ywaylsdttk iayqlatsvk efslfyvdli ilqgigmfpf klllvgslig 601 fplvkikakt prqrnelynp pifnfglqlp qpililiitl iysvmstkil tsglayfiig 661 fyvykyqlif atdhlphstg kvwplifrri ivglllfqlt mtgtlagfeg gwvlssclfp 721 lpvvtlcfly dfeknylpls kyialssire yerdnstvns aneeesyayp yavselegpm 781 ld // LOCUS NP_013343 321 aa linear PLN 30-JUN-2025 DEFINITION sterol homeostasis protein ARV1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013343 VERSION NP_013343.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182129.1 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09556. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..321 /product="sterol homeostasis protein ARV1" /calculated_mol_wt="38063" Region 1..287 /region_name="Arv1" /note="Arv1-like family; cl21705" /db_xref="CDD:473938" CDS 1..321 /gene="ARV1" /locus_tag="YLR242C" /coded_by="NM_001182129.1:1..966" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:12145310]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:12145310]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:23668914]" /experiment="EXISTENCE:genetic interaction:GO:0035376 sterol import [PMID:11063737]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:18287539]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:15173322]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:18287539]" /experiment="EXISTENCE:mutant phenotype:GO:0032366 intracellular sterol transport [PMID:15173322]" /experiment="EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:11063737]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:18287539]" /experiment="EXISTENCE:mutant phenotype:GO:0097036 regulation of plasma membrane sterol distribution [PMID:23668914]" /note="Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution; human ARV1, required for normal cholesterol and bile acid homeostasis, can complement yeast arv1 null mutant; human variant causing early onset epileptic encephalopathy is unable to rescue the yeast null" /db_xref="GeneID:850943" /db_xref="SGD:S000004232" ORIGIN 1 micitcmrpv dslytvysnd hiqltdcpyc qetvdkyvei dnvllfidll llkagayrhl 61 vfnalelhls kypkrkalnd cqclrdytqa llfnvknwfc kydrlnrlwl lllsfeiylt 121 wvteeskyiy ylnrnnndgk limlskklpe sfkwdsaimr ntitskvftw sppiqylyfa 181 sycildvslf htftqyfilk klhwkhysvs skdvisytil lsygakifpi lmliwpydtl 241 ismsiikwva nlyiieslki vtnlsywnii kifisvsllr yfmvkpiliv fvakfnfsvi 301 knlihqefil llqksgtyll l // LOCUS NP_013344 272 aa linear PLN 30-JUN-2025 DEFINITION putative signal sequence-binding GTPase GPN3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013344 VERSION NP_013344.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182130.1 REFERENCE 1 (residues 1 to 272) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 272) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 272) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 272) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09557. Method: conceptual translation. FEATURES Location/Qualifiers source 1..272 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..272 /product="putative signal sequence-binding GTPase GPN3" /calculated_mol_wt="30522" Region 5..251 /region_name="GPN3" /note="GPN-loop GTPase 3; cd17872" /db_xref="CDD:349781" Site order(11..18,173..174,176..177,235..237) /site_type="active" /note="putative active site [active]" /db_xref="CDD:349781" CDS 1..272 /gene="GPN3" /locus_tag="YLR243W" /coded_by="NM_001182130.1:1..819" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:23267056]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:23324351]" /note="Putative GTPase with a role in biogenesis of RNA pol II and polIII; may be involved in assembly of RNA polymerases II and III and in their transport into the nucleus; may have a role in sister chromatid cohesion; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn2p" /db_xref="GeneID:850944" /db_xref="SGD:S000004233" ORIGIN 1 msrvgvmvlg pagagkstfc nsiishmqtv grrahivnld paaeatkyef tidirdlisl 61 ddvmeemdlg pngaliycfe yllknldwld eeigdfndey lifdcpgqie lythipvlpn 121 ivrhltqqln fnlcatylle apfvidsskf fsgalsamsa millelphin vlskldlikg 181 dinkkklkrf lnpdamllme tegmnqasnp kflrlnqcia nlvddfgmvq flplesnnpd 241 sietilsyvd ditqwaegqe qkepndqidv ee // LOCUS NP_013345 387 aa linear PLN 30-JUN-2025 DEFINITION methionine aminopeptidase MAP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013345 VERSION NP_013345.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182131.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09558. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..387 /product="methionine aminopeptidase MAP1" /EC_number="3.4.11.18" /calculated_mol_wt="43242" Region 23..379 /region_name="APP_MetAP" /note="A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; cl00279" /db_xref="CDD:469704" Site order(202,219,230,294,327,358) /site_type="active" /db_xref="CDD:238519" CDS 1..387 /gene="MAP1" /locus_tag="YLR244C" /coded_by="NM_001182131.1:1..1164" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:11968008]" /experiment="EXISTENCE:direct assay:GO:0070006 metalloaminopeptidase activity [PMID:2246265]" /experiment="EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:21124907]" /note="Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; apo-Map1p is activated by the GTP-dependent zinc transferase Zng1p, especially during zinc starvation; interacts with Zng1p via an N-terminal Zn finger domain" /db_xref="GeneID:850945" /db_xref="SGD:S000004234" ORIGIN 1 mstatttvtt sdqashptki ycsglqcgre tssqmkcpvc lkqgivsifc dtscyennyk 61 ahkalhnakd glegaydpfp kfkysgkvka sypltprryv pedipkpdwa anglpvseqr 121 ndrlnnipiy kkdqikkirk acmlgrevld iaaahvrpgi ttdeldeivh netikrgayp 181 splnyynfpk slctsvnevi chgvpdktvl kegdivnldv slyyqgyhad lnetyyvgen 241 iskealntte tsreclklai kmckpgttfq elgdhiekha tenkcsvvrt ycghgvgeff 301 hcspniphya knrtpgvmkp gmvftiepmi negtwkdmtw pddwtsttqd gklsaqfeht 361 llvtehgvei ltarnkkspg gprqrik // LOCUS NP_013346 142 aa linear PLN 30-JUN-2025 DEFINITION cytidine deaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013346 VERSION NP_013346.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182132.1 REFERENCE 1 (residues 1 to 142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 142) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09559. Method: conceptual translation. FEATURES Location/Qualifiers source 1..142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..142 /product="cytidine deaminase" /EC_number="3.5.4.5" /calculated_mol_wt="15405" Region 12..141 /region_name="cyt_deam_tetra" /note="cytidine deaminase, homotetrameric; TIGR01354" /db_xref="CDD:273572" CDS 1..142 /gene="CDD1" /locus_tag="YLR245C" /coded_by="NM_001182132.1:1..429" /experiment="EXISTENCE:direct assay:GO:0004126 cytidine deaminase activity [PMID:10501935]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:11292850]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11292850|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006216 cytidine catabolic process [PMID:10501935]" /experiment="EXISTENCE:direct assay:GO:0006217 deoxycytidine catabolic process [PMID:10501935]" /experiment="EXISTENCE:direct assay:GO:0008655 pyrimidine-containing compound salvage [PMID:10501935]" /note="Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm" /db_xref="GeneID:850946" /db_xref="SGD:S000004235" ORIGIN 1 mkvggiedrq lealkraalk acelsyspys hfrvgcsilt nndviftgan venasysnci 61 caersamiqv lmaghrsgwk cmvicgdsed qcvspcgvcr qfinefvvkd fpivmlnstg 121 srskvmtmge llpmafgpsh ln // LOCUS NP_013347 359 aa linear PLN 30-JUN-2025 DEFINITION palmitoyltransferase ERF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013347 VERSION NP_013347.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182133.1 REFERENCE 1 (residues 1 to 359) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 359) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 359) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 359) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09560. Method: conceptual translation. FEATURES Location/Qualifiers source 1..359 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..359 /product="palmitoyltransferase ERF2" /EC_number="2.3.1.225" /calculated_mol_wt="40968" Region 47..359 /region_name="COG5273" /note="Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]" /db_xref="CDD:227598" CDS 1..359 /gene="ERF2" /locus_tag="YLR246W" /coded_by="NM_001182133.1:1..1080" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10490616]" /experiment="EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:12193598]" /experiment="EXISTENCE:direct assay:GO:0018345 protein palmitoylation [PMID:12193598]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:10490616]" /experiment="EXISTENCE:mutant phenotype:GO:0016409 palmitoyltransferase activity [PMID:12193598]" /experiment="EXISTENCE:mutant phenotype:GO:0018345 protein palmitoylation [PMID:16751107|PMID:10490616]" /experiment="EXISTENCE:physical interaction:GO:0031211 endoplasmic reticulum palmitoyltransferase complex [PMID:12193598]" /note="Subunit of a palmitoyltransferase; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole; palmitoyltransferase is composed of Erf2p and Shr5p" /db_xref="GeneID:850947" /db_xref="SGD:S000004236" ORIGIN 1 malvsrrstr sestsitkee htgegsltkl ffrwlvtleg dqdindgkgy islpnvsnyi 61 fflggrfrtv kgakplwlgv llaivcpmvl fsifeahklw htqngykvlv iffyyfwvit 121 lasfirtats dpgvlprnih lsqlrnnyqi pqeyynlitl pthssiskdi tikycpscri 181 wrpprsshcs tcnvcvmvhd hhciwvnnci gkrnyrffli fllgailssv illtncaihi 241 aresggprdc pvailllcya gltlwypail ftyhifmagn qqttreflkg igskknpvfh 301 rvvkeeniyn kgsflknmgh lmleprgpsf vsarkpheag dwrfmdlspa hsfekiqki // LOCUS NP_013348 1556 aa linear PLN 30-JUN-2025 DEFINITION E3 ubiquitin-protein ligase IRC20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013348 VERSION NP_013348.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182134.1 REFERENCE 1 (residues 1 to 1556) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1556) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1556) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1556) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09561. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1556 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1556 /product="E3 ubiquitin-protein ligase IRC20" /calculated_mol_wt="180214" Region 383..602 /region_name="DEXQc_SHPRH" /note="DEXQ-box helicase domain of SHPRH; cd18070" /db_xref="CDD:350828" Site order(393..399,448,534..535) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350828" Region 1234..>1327 /region_name="RAD18" /note="RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]; COG5432" /db_xref="CDD:227719" Region 1234..1277 /region_name="RING-HC_IRC20-like" /note="RING finger, HC subclass, found in Saccharomyces cerevisiae increased recombination centers protein 20 (IRC20) and similar proteins; cd23135" /db_xref="CDD:438497" Region 1356..1485 /region_name="SF2_C_SNF" /note="C-terminal helicase domain of the SNF family helicases; cd18793" /db_xref="CDD:350180" Site order(1388..1389,1397,1437,1458..1459) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:350180" Site order(1443..1444,1446,1469,1472) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350180" CDS 1..1556 /gene="IRC20" /locus_tag="YLR247C" /coded_by="NM_001182134.1:1..4671" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:24155900]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:22367032]" /experiment="EXISTENCE:genetic interaction:GO:0045003 double-strand break repair via synthesis-dependent strand annealing [PMID:22367032]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:24155900]" /experiment="EXISTENCE:mutant phenotype:GO:0045003 double-strand break repair via synthesis-dependent strand annealing [PMID:22367032]" /note="E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent NHEJ pathway; controls 2-micron plasmid copy number by regulating the levels of the Flp1p recombinase; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; null mutant displays increased levels of spontaneous Rad52p foci" /db_xref="GeneID:850949" /db_xref="SGD:S000004237" ORIGIN 1 msavgallar eynvtaekcd fflengsfds viaalpalnq eqetvtqkvs kngkelinva 61 svnieiperi slsnngrqlf kfivdieilp cendneatlv vssdsvslfq igfkmennsk 121 iavdkqlpli ldicahknqe ralrnqlenr kslerkpsrk rrkknsnvnd pekllksrih 181 elslsykdfe cspvvfrynd ssltwvlsfn lklkflnnkf nrfsveanqi ldltfsnrde 241 neferyhkhs hihsnfiqkq fisqileysk drlskikpfl pqsipdlkvn llpfqresve 301 wmlikeghgn slsdtptvid evglidfmne yyaygyelia rspdevgpsl lwnkltgyil 361 ttedaahlyn qyrkerlsgd ypvcakgvla eemglgktie ilslillnrr klkdseatfi 421 ddenrtitkt kttliicpna ilkqwleeie lhanslkwyt yrgyneimkd cktvdeavqq 481 lcqydiivts yniiatevhh aefnrsirsr rlkspkydys splalmqfyr iildevqmlr 541 ssstysakct sllhrihtwg vsgtpiqniy nfrmimsylk lhpfcdevdf irtlqeeikl 601 rneakdytsn dfvcqlkgvr fsikdcmnif yrydlcirhs kanvasqihi prqhnfiipl 661 efapiewdny lnlwnnflel sgynsdgsgs prvsnaflne wlsrlryicc halfpeilst 721 rqkrlhghls risniddili smrmdafdsl igyyrerfhl sikqaqyele isntpakale 781 sfikirddlm ihirqkfnve dpfdkslnls ededehmder fgeketssgd esdreingak 841 nhdnhnndgm lsnhlkkkgl rammnllhdc yfflgsvyyn lgtrkleead dkhrkektee 901 vvysdvfpkn eleeieenrl leqenyanae ilrksilsse arkvdmtikm artkfapmts 961 niplrlinie fdhkndyssn lavsrcfksl sklieglneq tknfnellde lliiiyepvh 1021 rtedddstnk iigneeysts idsqdkifsl lgcleiilqn rdniltsese vkipkhlvpe 1081 gsiiskyqkq llnslrlisg tplrtvfdel knsrivrris ssnesestiq nfedyllqye 1141 veskslfkyn kqvreslkil gsiynaktey ysqlqrisds lvslhslsap qlshlirtin 1201 kslggtldak inniesrliy lknlsrlkdt lndnqilscs iclgeveiga iikcghyfck 1261 sciltwlrah skcpickgfc sisevynfkf knstekreke iqeprregad ssqdnsnens 1321 iisnmsevek lfgnkyeqfh qinevhqihi kesfgakidf viklisylrl kseqenadpp 1381 qvilysqkte ylkvigkvlk lyhiehlacl sntanvgeti nnfkrqpsvt clllnvktlg 1441 aglnlinakh iflldpilnn sdelqamgrn nrigqdeetf vwnfmirntv eenilrykci 1501 leerkrkeks kkgdkydeaq detdneesdd akfeisvvdq evsnehlwnc ffhgsd // LOCUS NP_013349 610 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase RCK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013349 VERSION NP_013349.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182135.1 REFERENCE 1 (residues 1 to 610) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 610) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 610) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 610) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 610) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09562. Method: conceptual translation. FEATURES Location/Qualifiers source 1..610 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..610 /product="serine/threonine protein kinase RCK2" /EC_number="2.7.11.1" /calculated_mol_wt="67931" Region 161..478 /region_name="STKc_RCK1-like" /note="Catalytic domain of RCK1-like Serine/Threonine Kinases; cd14096" /db_xref="CDD:270998" Site order(169..173,177,199,201,251,267..270,274,276,312..313, 315,317..318,320,364..365,368,381..385,387) /site_type="active" /db_xref="CDD:270998" Site order(169..172,177,199,201,251,267..270,274,317..318,320, 364..365) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270998" Site order(173,274,276,312..313,315,317,368,381..385,387) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270998" Site 364..385 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270998" CDS 1..610 /gene="RCK2" /locus_tag="YLR248W" /gene_synonym="CLK1; CMK3" /coded_by="NM_001182135.1:1..1833" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:11344302]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:8939941]" /experiment="EXISTENCE:genetic interaction:GO:0007231 osmosensory signaling pathway [PMID:11344302]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:15341652]" /experiment="EXISTENCE:mutant phenotype:GO:0007231 osmosensory signaling pathway [PMID:11344302]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:16381815|PMID:15341652]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:10778743]" /experiment="EXISTENCE:physical interaction:GO:0007231 osmosensory signaling pathway [PMID:11344302]" /note="Protein kinase involved in response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases; RCK2 has a paralog, RCK1, that arose from the whole genome duplication" /db_xref="GeneID:850950" /db_xref="SGD:S000004238" ORIGIN 1 mlkikalfsk kkpdqadlsq eskkpfkgkt rssgtnnkdv sqitsspkks fqdknivqyp 61 svvaddhhmk sltdelvtti dsdsspsdni ttenvetvts vpaidvhess egqlssdpli 121 sdeslseqse iisdiqddst dddnmedeip eksfleqkel igyklinkig egafskvfra 181 ipaknssnef ltknykavai kvikkadlss ingdhrkkdk gkdstktssr dqvlkevalh 241 ktvsagcsqi vafidfqetd syyyiiqell tggeifgeiv rltyfsedls rhvikqlala 301 vkhmhslgvv hrdikpenll fepieftrsi kpklrksddp qtkadegift pgvggggigi 361 vkladfglsk qifskntktp cgtvgytape vvkdehysmk vdmwgigcvl ytmlcgfppf 421 ydekidtlte kisrgeytfl kpwwdeisag aknavaklle lepskrydid qflddpwlnt 481 fdclpkeges sqkkagtser rhphkkqfql fqrdssllfs paavamrdaf dignavkrte 541 edrmgtrggl gslaedeele dsysgaqgde qleqnmfqlt ldtstilqrr kkvqendvgp 601 tipisatire // LOCUS NP_013350 1044 aa linear PLN 30-JUN-2025 DEFINITION translation elongation factor EF-3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013350 VERSION NP_013350.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182136.1 REFERENCE 1 (residues 1 to 1044) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1044) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1044) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1044) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1044) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1044) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1044) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1044) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1044) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09563. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1044 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1044 /product="translation elongation factor EF-3" /calculated_mol_wt="115814" Site order(112,115..116,147..148,151,154..155,158,188..189,192, 195..196,199,224..225,228,231..232,264..265,268,271..272) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 129..158 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 170..200 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 208..232 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 244..273 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 336..411 /region_name="4HB" /note="Four helical bundle domain; pfam17947" /db_xref="CDD:407796" Region 437..973 /region_name="Uup" /note="ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; COG0488" /db_xref="CDD:440254" Region 794..861 /region_name="CD_eEF3" /note="chromodomain-like insertion in an ATPase domain of elongation factor eEF3; cd18626" /db_xref="CDD:349276" Site order(795..799,814,829..832,836,838..841,843..844,852, 855..856) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:349276" Site 813 /site_type="other" /note="ABC2 interface [polypeptide binding]" /db_xref="CDD:349276" CDS 1..1044 /gene="YEF3" /locus_tag="YLR249W" /gene_synonym="TEF3" /coded_by="NM_001182136.1:1..3135" /experiment="EXISTENCE:direct assay:GO:0003746 translation elongation factor activity [PMID:2670939]" /experiment="EXISTENCE:direct assay:GO:0005840 ribosome [PMID:9553076]" /experiment="EXISTENCE:direct assay:GO:0006415 translational termination [PMID:20534490]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:23451152]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:19666721]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:34916334]" /experiment="EXISTENCE:genetic interaction:GO:0006414 translational elongation [PMID:19666721]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:34916334|PMID:19666721]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:16954224]" /note="Translation elongation factor 3; contains two ABC cassettes; binds and hydrolyzes ATP; interacts with mRNA independently of translation; involved in frameshifting at stalled ribosomes; YEF3 has a paralog, HEF3, that arose from the whole genome duplication" /db_xref="GeneID:850951" /db_xref="SGD:S000004239" ORIGIN 1 msdsqqsikv leelfqklsv atadnrheia sevasflngn iiehdvpehf fgelakgikd 61 kktaanamqa vahianqsnl spsvepyivq lvpaictnag nkdkeiqsva setlisivna 121 vnpvaikall phltnaivet nkwqekiail aaisamvdaa kdqvalrmpe lipvlsetmw 181 dtkkevkaaa taamtkatet vdnkdierfi psliqciadp tevpetvhll gattfvaevt 241 patlsimvpl lsrglneret gikrksavii dnmcklvedp qviapflgkl lpglksnfat 301 iadpearevt lralktlrrv gnvgeddaip evshagdvst tlqvvnellk detvaprfki 361 vveyiaaiga dlideriidq qawfthitpy mtiflhekka kdildefrkr avdnipvgpn 421 fddeedeged lcncefslay gakillnktq lrlkrarryg icgpngcgks tlmraiangq 481 vdgfptqeec rtvyvehdid gthsdtsvld fvfesgvgtk eaikdklief gftdemiamp 541 isalsggwkm klalaravlr nadillldep tnhldtvnva wlvnylntcg itsitishds 601 vfldnvceyi inyeglklrk ykgnftefvk kcpaakayee lsntdlefkf pepgylegvk 661 tkqkaivkvt nmefqypgts kpqitdinfq cslssriavi gpngagkstl invltgellp 721 tsgevythen criayikqha fahieshldk tpseyiqwrf qtgedretmd ranrqinend 781 aeamnkifki egtprriagi hsrrkfknty eyecsfllge nigmkserwv pmmsvdnawi 841 prgelveshs kmvaevdmke alasgqfrpl trkeieehcs mlgldpeivs hsrirglsgg 901 qkvklvlaag twqrphlivl deptnyldrd slgalskalk efeggviiit hsaeftknlt 961 eevwavkdgr mtpsghnwvs gqgagpriek kedeedkfda mgnkiaggkk kkklssaelr 1021 kkkkermkkk kelgdayvss deef // LOCUS NP_013351 234 aa linear PLN 30-JUN-2025 DEFINITION nucleobindin SSP120 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013351 VERSION NP_013351.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182137.1 REFERENCE 1 (residues 1 to 234) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 234) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 234) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 234) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09564. Method: conceptual translation. FEATURES Location/Qualifiers source 1..234 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..234 /product="nucleobindin SSP120" /calculated_mol_wt="27158" CDS 1..234 /gene="SSP120" /locus_tag="YLR250W" /coded_by="NM_001182137.1:1..705" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Protein packaged into COPII vesicles for ER to Golgi trafficking; forms a complex with Emp47p that may function in trafficking plasma membrane glycoproteins through early secretory pathway; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" /db_xref="GeneID:850952" /db_xref="SGD:S000004240" ORIGIN 1 mrflrgfvfs laftlykvta taeigseinv eneappdgls weewhmdheh qlkdytpetf 61 falhdikkkg fldendilsl yglnreeivg agdgmgqhde sekidnemak rvvslimrll 121 dvddntkitk eeylqfakrg nkfpdlgvgv ghhsdfeley eihhwnkfhk dkdpdvkvvh 181 kediehellh heheieheee iqrgasratv itddelesri elknipekfk ngif // LOCUS NP_013352 197 aa linear PLN 30-JUN-2025 DEFINITION ethanol metabolism protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013352 VERSION NP_013352.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182138.1 REFERENCE 1 (residues 1 to 197) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 197) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 197) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09565. Method: conceptual translation. FEATURES Location/Qualifiers source 1..197 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..197 /product="ethanol metabolism protein" /calculated_mol_wt="22784" Region 115..176 /region_name="Mpv17_PMP22" /note="Mpv17 / PMP22 family; pfam04117" /db_xref="CDD:461182" CDS 1..197 /gene="SYM1" /locus_tag="YLR251W" /coded_by="NM_001182138.1:1..594" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15189984|PMID:23045398]" /experiment="EXISTENCE:mutant phenotype:GO:0006067 ethanol metabolic process [PMID:15189984]" /note="Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; lysine auxotroph proposed to function in pyrimidine metabolism; homologous to mammalian peroxisomal membrane protein Mpv17; human homolog MPV17 is implicated in hepatocerebral mtDNA depletion syndromes (MDDS), and complements yeast null mutant" /db_xref="GeneID:850953" /db_xref="SGD:S000004241" ORIGIN 1 mkllhlyeas lkrrpkttna imtgalfgig dvsaqllfpt skvnkgydyk rtaraviygs 61 lifsfigdkw ykilnnkiym rnrpqyhwsn mvlrvavdql afaplglpfy ftcmsimegr 121 sfdvaklkik eqwwptlltn wavwplfqai nfsvvplqhr llavnvvaif wntylsykns 181 kvmekdkvpv hyppvve // LOCUS NP_013354 569 aa linear PLN 30-JUN-2025 DEFINITION Cqd2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013354 VERSION NP_013354.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182140.1 REFERENCE 1 (residues 1 to 569) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 569) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 569) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 569) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09566. Method: conceptual translation. FEATURES Location/Qualifiers source 1..569 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..569 /product="Cqd2p" /calculated_mol_wt="65786" Region 147..408 /region_name="ADCK1-like" /note="aarF domain containing kinase 1 and similar proteins; cd13969" /db_xref="CDD:270871" Site order(197..199,204..205,207,217,219,278,298..301,344, 348..349,351,371..372) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:270871" CDS 1..569 /gene="CQD2" /locus_tag="YLR253W" /gene_synonym="MCP2; MRX13" /coded_by="NM_001182140.1:1..1710" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:23781023]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:23781023]" /experiment="EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:23781023]" /experiment="EXISTENCE:genetic interaction:GO:0055088 lipid homeostasis [PMID:23781023]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:23781023]" /note="Mitochondrial protein involved in lipid homeostasis; involved in mobilization of CoQ from its site of synthesis on the inner mitochondrial membrane to other sites of action; associates with mitochondrial ribosome; involved in mitochondrial morphology; non-essential gene which interacts genetically with MDM10, and other members of ERMES complex; transcription is periodic during metabolic cycle; homologous to human aarF domain containing kinase, ADCK1" /db_xref="GeneID:850955" /db_xref="SGD:S000004243" ORIGIN 1 mmtkaffnkl pfevfrryvr tgksipqrsp rtrksllvgg tiasavvlyn fndtfhdsvk 61 htalttkria vvtqattrcf yhykralnks yenkkereva lnkchkmcal itlhalrsng 121 giyiklgqhi gamtyllpke wtdtmiplqd hcpestyeei delfkedlgt siedmflefn 181 ktpigvasla qvhvaklkns dgkgssvavk cqhpslkefi pldvmltrtv felldvffpd 241 ypltwlgdel qssiyvelnf tkeaenaekt rhyfskfkkq talkipkvie shkrilimey 301 vggkrlddle yidshgisrs evssclshif nnmiftpnvg ihcdphggnl airsvkpakd 361 ngyhnfeivl fdhglyryps trtrrlyakf wlsllfdkdq tkmkkyakgf anitdeqfpl 421 laaaitgrsi daalnydist srtqeemdvm angilegtll sdlmsilsri prvvllilkt 481 ndltrhldec lqnplgpert flimtqycak tvydekveri nseyarwsik wmwenltnwi 541 vyerrinqly fydfvlwwkk fipktwlss // LOCUS NP_013355 189 aa linear PLN 30-JUN-2025 DEFINITION Ndl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013355 VERSION NP_013355.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182141.1 REFERENCE 1 (residues 1 to 189) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 189) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 189) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 189) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09567. Method: conceptual translation. FEATURES Location/Qualifiers source 1..189 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..189 /product="Ndl1p" /calculated_mol_wt="21399" Region <35..>117 /region_name="COG2433" /note="Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only]" /db_xref="CDD:441980" CDS 1..189 /gene="NDL1" /locus_tag="YLR254C" /coded_by="NM_001182141.1:1..570" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:15965467]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:15965467]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:15965467]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:15965467]" /experiment="EXISTENCE:physical interaction:GO:0030473 nuclear migration along microtubule [PMID:15965467]" /note="Homolog of nuclear distribution factor NudE; NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends; localizes to cytosol, nucleus and peroxisomes" /db_xref="GeneID:850956" /db_xref="SGD:S000004244" ORIGIN 1 mvpnldleta iqiissletq lselegatke yendleqvis klksdllesq qqnkcnkkqi 61 tdleiqvdel eneniqlrnk ietlqlesdr rlernvlleh elldtkealq klrvskeeat 121 sgetrrntrs lpsqnkkmkl fkdtikvstt sstlylqnma ktnnaarshc nipntqitqs 181 tviattssv // LOCUS NP_001335798 117 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR255C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335798 VERSION NP_001335798.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348858.1 REFERENCE 1 (residues 1 to 117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 117) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80318. Method: conceptual translation. FEATURES Location/Qualifiers source 1..117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..117 /product="uncharacterized protein" /calculated_mol_wt="13431" CDS 1..117 /locus_tag="YLR255C" /coded_by="NM_001348858.1:1..354" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:850957" /db_xref="SGD:S000004245" ORIGIN 1 mgvggtrivs frqpnyypvt qqkgasqtga vaqpyssycg llmrwavvei rrrgkgkgrk 61 rkrerekght kfrirrrsyl yfirsclvrp yssgnkknsc sfhkmlaiei vlclkar // LOCUS NP_013357 1502 aa linear PLN 30-JUN-2025 DEFINITION Hap1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013357 VERSION NP_013357.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182143.1 REFERENCE 1 (residues 1 to 1502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1502) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09568. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1502 /product="Hap1p" /calculated_mol_wt="165978" Region 59..99 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(59,63,68..71,73,76,86) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(64,67,74,81,84,93) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 99..130 /region_name="ZIP_Hap1" /note="Leucine zipper Dimerization domain of transcription factor Hap1 and similar fungal proteins; cd14655" /db_xref="CDD:271239" Region 100..130 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:271239" Site 100 /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:271239" Site order(107,110..111,113..114,117..118,120..121,124..125, 127..128) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:271239" Region 476..>814 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..1502 /gene="HAP1" /locus_tag="YLR256W" /gene_synonym="CYP1" /coded_by="NM_001182143.1:1..4509" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9118994|PMID:3030565]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:2823123]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8182072|PMID:25378625]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25378625]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:genetic interaction:GO:0043457 regulation of cellular respiration [PMID:2851658]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17785431]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:2823123]" /experiment="EXISTENCE:mutant phenotype:GO:0043457 regulation of cellular respiration [PMID:2182199]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2823123]" /experiment="EXISTENCE:mutant phenotype:GO:0071169 establishment of protein localization to chromatin [PMID:17785431]" /experiment="EXISTENCE:mutant phenotype:GO:0071456 cellular response to hypoxia [PMID:17785431]" /note="Zinc finger transcription factor; involved in the complex regulation of gene expression in response to levels of heme and oxygen; localizes to the mitochondrion as well as to the nucleus; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus" /db_xref="GeneID:850958" /db_xref="SGD:S000004246" ORIGIN 1 msntpynssv psiasmtqss vsrspnmhta ttpgantssn spplhmssds skikrkrnri 61 plscticrkr kvkcdklrph cqqctktgva hlchymeqtw aeeaekellk dnelkklrer 121 vkslektlsk vhsspssnsl ksyntpessn lfmgsdehtt lvnantgsas sashmhqqqq 181 qqqqqeqqqd fsrsananan ssslsisnky dndeldltkd fdllhiksng tihlgathwl 241 simkgdpylk llwghifamr eklnewyyqk nsysklkssk cpinhaqapp saaaaatrkc 301 pvdhsafssg mvapkeetpl prkcpvdhtm fssgmippre dtssqkrcpv dhtmysagmm 361 ppkdetpspf stkamidhnk htmnppqskc pvdhrnymkd ypsdmansss npasrcpidh 421 ssmkntaalp asthntiphh qpqsgshars hpaqsrkhds ymtesevlat lcemlppkrv 481 ialfiekffk hlypaipild eqnfknhvnq mlslssmnpt vnnfgmsmps sstlenqpit 541 qinlpklsds cnlgiliiil rltwlsipsn scevdlgees gsflvpness nmsasaltsm 601 akeeslllkh etpvealelc qkylikfdel ssisnnnvnl ttvqfaifyn fymksasndl 661 ttltntnntg manpghdses hqillsnitq mafscglhrd pdnfpqlnat ipatsqdvsn 721 ngskkanpst nptlnnnmsa attnsssrsg sadsrsgsnp vnkkenqvsi erfkhtwrki 781 wyyivsmdvn qslslgsprl lrnlrdfsdt klpsasridy vrdikeliiv knftlffqid 841 lciiavlnhi lnvslarsvr kfeldslinl lknltygten vndvvsslin kgllptsegg 901 svdsnndeiy glpklpdiln hgqhnqnlya dgrntsssdi dkkldlphes ttralffskh 961 mtirmllyll nyilfthyep mgsedpgtni lakeyaqeal nfamdgyrnc miffnnirnt 1021 nslfdymnvi lsypcldigh rslqfivcli lrakcgpltg mressiitng tssgfnssve 1081 dedvkvkqes sdelkkddfm kdvnldsgds laeilmsrml lfqkltkqls kkynyairmn 1141 kstgffvsll dtpskksdsk sggssfmlgn wkhpkvsnms gflagdkdql qkcpvyqdal 1201 gfvsptgane gsapmqgmsl qgstarmggt qlppirsykp itytssnlrr mnetgeaeak 1261 rrrfndgyid nnsnndiprg ispkpsngls svqpllssfs mnqlnggtip tvpsltnits 1321 qmgalpsldr ittnqinlpd psrdeafdns ikqmtpmtsa fmnanttips stlngnmnmn 1381 gagtantdts angsalstlt spqgsdlasn satqykpdle dflmqnsnfn glminpsslv 1441 evvggyndpn nlgrndavdf lpvdnveidg vgikinyhll tsiyvtsils ytvleddand 1501 ek // LOCUS NP_058173 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058173 VERSION NP_058173.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184409.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09569. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..440 /product="gag protein" /calculated_mol_wt="48872" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YLR256W-A" /coded_by="NM_001184409.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:850959" /db_xref="SGD:S000007377" ORIGIN 1 mesqqlsqhp hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_013358 321 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR257W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013358 VERSION NP_013358.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182144.1 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09570. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..321 /product="uncharacterized protein" /calculated_mol_wt="35867" CDS 1..321 /locus_tag="YLR257W" /coded_by="NM_001182144.1:1..966" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /note="hypothetical protein; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850961" /db_xref="SGD:S000004247" ORIGIN 1 mvdargstpc ligdsirnvn dgnsldfqyt nqfneeseas rlltpqtssn halskmqkdd 61 dirdrsytsv aelnregall tdevdlenvd askvrsnrdd leaeekrkkl lllkkkqrnk 121 sinsesfssp slrasksnsl itstdpvedh iskysssgtp enitgeadde dediirnsyg 181 qmiknnsnrp hlakgesyqs aeqeidhtap eksekrqers grsfdrqkss aeflrslsrs 241 isrgptknkt vspskgedsr mystsnysis lvdlengpki ipetleeeqe daekegvlme 301 degneeytkd leeaankaqp q // LOCUS NP_013359 705 aa linear PLN 30-JUN-2025 DEFINITION glycogen (starch) synthase GSY2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013359 VERSION NP_013359.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182145.1 REFERENCE 1 (residues 1 to 705) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 705) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 705) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 705) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09571. Method: conceptual translation. FEATURES Location/Qualifiers source 1..705 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..705 /product="glycogen (starch) synthase GSY2" /EC_number="2.4.1.11" /calculated_mol_wt="79948" Region 7..616 /region_name="GT3_GSY2-like" /note="glycogen synthase GSY2 and similar proteins; cd03793" /db_xref="CDD:340824" CDS 1..705 /gene="GSY2" /locus_tag="YLR258W" /coded_by="NM_001182145.1:1..2118" /experiment="EXISTENCE:direct assay:GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity [PMID:21835915]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922|PMID:20555403|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:2001069 glycogen binding [PMID:38832010]" /experiment="EXISTENCE:mutant phenotype:GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity [PMID:1908457]" /experiment="EXISTENCE:mutant phenotype:GO:0005978 glycogen biosynthetic process [PMID:1908457]" /note="Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress" /db_xref="GeneID:850962" /db_xref="SGD:S000004248" ORIGIN 1 msrdlqnhll fetatevanr vggiysvlks kapitvaqyk dhyhligpln katyqnevdi 61 ldwkkpeafs demrpvqhal qtmesrgvhf vygrwliega pkvilfdlds vrgysnewkg 121 dlwslvgips pendfetnda illgytvawf lgevahldsq haivahfhew lagvalplcr 181 krridvvtif tthatllgry lcasgsfdfy nclesvdvdh eagrfgiyhr ycieraaahs 241 advfttvsqi tafeaehllk rkpdgilpng lnvikfqafh efqnlhalkk ekindfvrgh 301 fhgcfdfdld ntlyffiagr yeyknkgadm fiealarlny rlkvsgskkt vvafivmpak 361 nnsftvealk gqaevralen tvhevttsig krifdhairy phnglttelp tdlgellkss 421 dkvmlkrril alrrpegqlp pivthnmvdd andlilnkir qvqlfnspsd rvkmifhpef 481 lnannpilgl dydefvrgch lgvfpsyyep wgytpaectv mgvpsittnv sgfgaymedl 541 ietnqakdyg iyivdrrfka pdesveqlvd ymeefvkktr rqrinqrnrt erlsdlldwk 601 rmgleyvkar qlalrrgypd qfrelvgeel ndsnmdalag gkklkvarpl svpgsprdlr 661 snstvymtpg dlgtlqevnn addyfslgvn paadddddgp yadds // LOCUS NP_013360 572 aa linear PLN 30-JUN-2025 DEFINITION chaperone ATPase HSP60 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013360 VERSION NP_013360.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182146.1 REFERENCE 1 (residues 1 to 572) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 572) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 572) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 572) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09572. Method: conceptual translation. FEATURES Location/Qualifiers source 1..572 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..572 /product="chaperone ATPase HSP60" /calculated_mol_wt="60621" Region 25..548 /region_name="GroEL" /note="GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; cd03344" /db_xref="CDD:239460" Site order(25,29,46,57..60,62,67..68,70,80,82,90,94,97,218,250, 278,406,408,481,538,541..547) /site_type="other" /note="ring oligomerisation interface [polypeptide binding]" /db_xref="CDD:239460" Site order(52..54,108,112,171,420,437,476,518,520) /site_type="other" /note="ATP/Mg binding site [chemical binding]" /db_xref="CDD:239460" Site order(130,456,474,483,485..486,489) /site_type="active" /note="stacking interactions [active]" /db_xref="CDD:239460" Site order(162,207,214,397,431..432) /site_type="other" /note="hinge regions" /db_xref="CDD:239460" CDS 1..572 /gene="HSP60" /locus_tag="YLR259C" /gene_synonym="CPN60; MIF4; MNA2" /coded_by="NM_001182146.1:1..1719" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:10869431]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:10869431]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:11502169|PMID:8097278|PMID:14576278|PM ID:24769239]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:7902576|PMID:9256426]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9256426]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:14597775|PMID:10869431]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:14597775]" /experiment="EXISTENCE:mutant phenotype:GO:0006458 'de novo' protein folding [PMID:1978929]" /experiment="EXISTENCE:mutant phenotype:GO:0042026 protein refolding [PMID:1359644]" /experiment="EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:1347713]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:1359644]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:1359644]" /experiment="EXISTENCE:mutant phenotype:GO:0051131 chaperone-mediated protein complex assembly [PMID:2645524]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:8097278]" /experiment="EXISTENCE:physical interaction:GO:0051087 protein-folding chaperone binding [PMID:9256426]" /note="Tetradecameric mitochondrial chaperonin; required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated" /db_xref="GeneID:850963" /db_xref="SGD:S000004249" ORIGIN 1 mlrssvvrsr atlrpllrra ysshkelkfg vegrasllkg vetlaeavaa tlgpkgrnvl 61 ieqpfgppki tkdgvtvaks ivlkdkfenm gakllqevas ktneaagdgt tsatvlgrai 121 ftesvknvaa gcnpmdlrrg sqvavekvie flsankkeit tseeiaqvat isangdshvg 181 kllasamekv gkegvitire grtledelev tegmrfdrgf ispyfitdpk sskvefekpl 241 lllsekkiss iqdilpalei snqsrrplli iaedvdgeal aacilnklrg qvkvcavkap 301 gfgdnrknti gdiavltggt vfteeldlkp eqctienlgs cdsitvtked tvilngsgpk 361 eaiqerieqi kgsiditttn syekeklqer laklsggvav irvggaseve vgekkdrydd 421 alnatraave egilpgggta lvkasrvlde vvvdnfdqkl gvdiirkait rpakqiiena 481 geegsviigk lideygddfa kgydasksey tdmlatgiid pfkvvrsglv dasgvaslla 541 ttevaivdap eppaaagagg mpggmpgmpg mm // LOCUS NP_013361 687 aa linear PLN 30-JUN-2025 DEFINITION sphinganine kinase LCB5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013361 VERSION NP_013361.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182147.1 REFERENCE 1 (residues 1 to 687) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 687) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 687) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 687) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09573. Method: conceptual translation. FEATURES Location/Qualifiers source 1..687 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..687 /product="sphinganine kinase LCB5" /EC_number="2.7.1.91" /calculated_mol_wt="77435" Region <267..>455 /region_name="PLN02958" /note="diacylglycerol kinase/D-erythro-sphingosine kinase" /db_xref="CDD:215517" CDS 1..687 /gene="LCB5" /locus_tag="YLR260W" /coded_by="NM_001182147.1:1..2064" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:12493772]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006665 sphingolipid metabolic process [PMID:9677363]" /experiment="EXISTENCE:direct assay:GO:0008481 sphingosine kinase activity [PMID:9677363]" /experiment="EXISTENCE:direct assay:GO:0009408 response to heat [PMID:11967828]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:12493772]" /experiment="EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:11278643]" /note="Minor sphingoid long-chain base kinase; possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules; LCB5 has a paralog, LCB4, that arose from the whole genome duplication" /db_xref="GeneID:850964" /db_xref="SGD:S000004250" ORIGIN 1 mtlkpskrrk grsrhsrkkq itsailteeg imikakpssp ytyanrmadk rsrssidnis 61 rtsfqsnisr tsfqsnsdnn sifetaslis cvtclsdtdt idrsetsttd tskddlsanp 121 klhypsvngq lpantvipyg rildaryiek eplhyydans spssplsssm snisekcdld 181 elessqkker kgnslsrgsn sssslltsrs pftklvevif arprrhdvvp krvslyidyk 241 phssshlkee ddlveeilkr sykntrrnks ifviinpfgg kgkakklfmt kakplllasr 301 csievvytky pghaieiare mdidkydtia casgdgiphe vinglyqrpd hvkafnniai 361 teipcgsgna msvschwtnn psystlclik sietridlmc csqpsyareh pklsflsqty 421 gliaetdint efirwmgpar felgvafnii qkkkypceiy vkyaakskne lknhylehkn 481 kgslefqhit mnkdnedcdn ynyeneyete nedededada ddedshlisr dladssadqi 541 keedfkikyp ldegipsdwe rldpnisnnl gifytgkmpy vaadtkffpa alpsdgtmdm 601 vitdartslt rmapillgld kgshvlqpev lhskilayki ipklgnglfs vdgekfplep 661 lqveimprlc ktllrngryv dtdfdsm // LOCUS NP_013362 108 aa linear PLN 30-JUN-2025 DEFINITION Vps63p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013362 VERSION NP_013362.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182148.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA64694. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..108 /product="Vps63p" /calculated_mol_wt="12787" CDS 1..108 /gene="VPS63" /locus_tag="YLR261C" /coded_by="NM_001182148.1:1..327" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /note="hypothetical protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect; decreased levels of protein in enolase deficient mutant" /db_xref="GeneID:850965" /db_xref="SGD:S000004251" ORIGIN 1 mkevtkmlyc allvtkviyq mkgksqpkre rkkqnywvlk slwkrpqrqa imsklyskrl 61 pnrclnfkta sqllwiakmq ivqtkinres liflqqrsrn kalvsvst // LOCUS NP_013363 215 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase YPT6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013363 VERSION NP_013363.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182149.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09574. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..215 /product="Rab family GTPase YPT6" /calculated_mol_wt="24282" Region 11..173 /region_name="Rab6" /note="Rab GTPase family 6 (Rab6); cd01861" /db_xref="CDD:206654" Site 11..12 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206654" Site 17..24 /site_type="other" /note="G1 box" /db_xref="CDD:206654" Site order(19..25,39,41,124..125,127,155..157) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206654" Site order(25..36,40..41) /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206654" Site order(35,40..48) /site_type="other" /note="Switch I region" /db_xref="CDD:206654" Site order(40,44..51,58,60) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206654" Site 42 /site_type="other" /note="G2 box" /db_xref="CDD:206654" Site order(43,45..47,62,64,71..72,75,79,81..84,173) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206654" Site order(43..44,46,64..65,72,74,76..78) /site_type="other" /note="putative GDI interaction site [polypeptide binding]" /db_xref="CDD:206654" Site 43..47 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206654" Site 60..64 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206654" Site 65..68 /site_type="other" /note="G3 box" /db_xref="CDD:206654" Site order(68,70..80) /site_type="other" /note="Switch II region" /db_xref="CDD:206654" Site 71..76 /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206654" Site 79..83 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206654" Site 88..93 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206654" Site 117..121 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206654" Site 124..127 /site_type="other" /note="G4 box" /db_xref="CDD:206654" Site 155..157 /site_type="other" /note="G5 box" /db_xref="CDD:206654" Site 171..173 /site_type="other" /note="Rab subfamily motif 4 (RabSF4)" /db_xref="CDD:206654" CDS 1..215 /gene="YPT6" /locus_tag="YLR262C" /coded_by="NM_001182149.1:1..648" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:24194547]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:24924636]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:24924636]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:12401784]" /experiment="EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:27462928]" /experiment="EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:12401784|PMID:9880327]" /experiment="EXISTENCE:mutant phenotype:GO:0000301 retrograde transport, vesicle recycling within Golgi [PMID:12401784]" /experiment="EXISTENCE:mutant phenotype:GO:0000407 phagophore assembly site [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:12401784]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:8923208]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:27462928]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:10990452|PMID:9880327|PMID:11160819]" /note="Rab family GTPase; required for endosome-to-Golgi, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; GTP-bound Ypt6p temporarily localizes to the Golgi, and dissociates from the membrane into its GDP-bound cytosolic form after Gyp6p GAP is recruited by Ypt32p, a late Golgi GTPase; required for anterograde trafficking of Atg9p to the PAS during starvation-induced autophagy under heat stress, and for the CVT pathway; activated by the Ric1-Rgp1 GEF complex; homolog of mammalian Rab6" /db_xref="GeneID:850966" /db_xref="SGD:S000004252" ORIGIN 1 msrsgksltk ykivflgeqg vgktslitrf mydtfddhyq atigidflsk tmylddktir 61 lqlwdtagqe rfrslipsyi rdsrvaiivy ditkrksfey idkwiedvkn ergdenvilc 121 ivgnksdlsd erqisteege kkakllgaki fmetstkagy nvkalfkkia kslpefqnse 181 stpldsenan sanqnkpgvi distaeeqeq sacqc // LOCUS NP_013364 64 aa linear PLN 30-JUN-2025 DEFINITION Tma7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013364 VERSION NP_013364.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184339.1 REFERENCE 1 (residues 1 to 64) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 64) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 64) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 64) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09575. Method: conceptual translation. FEATURES Location/Qualifiers source 1..64 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..64 /product="Tma7p" /calculated_mol_wt="6810" Region 3..59 /region_name="TMA7" /note="Translation machinery associated TMA7; pfam09072" /db_xref="CDD:462671" CDS 1..64 /gene="TMA7" /locus_tag="YLR262C-A" /coded_by="NM_001184339.1:1..195" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:16702403]" /note="hypothetical protein that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:850967" /db_xref="SGD:S000007246" ORIGIN 1 mssrqggkmk plkqkkkqqq dldpediafk ekqkadaaak kalmanmksg kplvgggikk 61 sgkk // LOCUS NP_013365 827 aa linear PLN 30-JUN-2025 DEFINITION Red1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013365 VERSION NP_013365.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182150.1 REFERENCE 1 (residues 1 to 827) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 827) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 827) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 827) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09576. Method: conceptual translation. FEATURES Location/Qualifiers source 1..827 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..827 /product="Red1p" /calculated_mol_wt="95408" Region 124..822 /region_name="Red1" /note="Rec10 / Red1; pfam07964" /db_xref="CDD:369621" CDS 1..827 /gene="RED1" /locus_tag="YLR263W" /coded_by="NM_001182150.1:1..2484" /experiment="EXISTENCE:direct assay:GO:0000800 lateral element [PMID:9060462]" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:11779793]" /experiment="EXISTENCE:direct assay:GO:0031490 chromatin DNA binding [PMID:12526806]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:9880561]" /experiment="EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:10848609]" /note="Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; promotes interhomolog recombination by phosphorylating Hop1p; also interacts with Mec3p and Ddc1p" /db_xref="GeneID:850968" /db_xref="SGD:S000004253" ORIGIN 1 meglkkkifg vclkndlaqt rnetkgihyg lmtletskql qeflhllvik reviqnfell 61 fhiinvavki tdsnlpsddi whfilklrfs seinidedsk vlnylletgi amenpvswkc 121 lavissilss vpqskkiitn lietehakki gqlfdniqdl qqgnflveil sncfkksasn 181 skkvekipql wqsrsknkff fenefypfss kngslqtcqf lcnnfmstls ftgilrqvsy 241 sgsetlknlr ifkkkddens yfiqciynki ylwldekapl eferkkirit knlknkiqik 301 lrqpfhecvr ttadktallf nktkgfqlef edeklgetff hnvnnipkis evqnflvldy 361 ieeepenege eeeqigrade qkedeeeesl delstpmvyp ikssiphnhn ekvqlvtpdr 421 svsirsdewd lksntedeeg nvladlkiss tketkrqtdy vhidsedqsp vvsaqmrkmr 481 restktleil rqefkdkdvq nkedqseqiq npfvntsslv vgksclvnpk ekpnidqtvv 541 gitelksnss ikkrdinild tifgqppskk qkqfhkkekk kqqkkltnfk piidvpsqdk 601 rnlrsnaptk pksikvsklr tdkkvtgeks spetaaekvd dqtvrsndeq amsratkekc 661 fpdvnegkei tkddakvsle skknnetfvd ssvvekhtpp dkdcnncnit dilesttvid 721 lqsphglsap gqntftnklq eqiyssinhf snelvrkisi inqelnkkil kelsekyqkl 781 fselqdnfqn dtnemlkfmg eikdmmnlpe dqlvhairtr kfdnnkr // LOCUS NP_013366 67 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS28 RPS28B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013366 VERSION NP_013366.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182151.1 REFERENCE 1 (residues 1 to 67) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 67) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 67) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 67) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09577. Method: conceptual translation. FEATURES Location/Qualifiers source 1..67 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..67 /product="40S ribosomal protein eS28 RPS28B" /calculated_mol_wt="7434" Region 8..67 /region_name="S1_S28E" /note="S28E, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. S28E protein is a component of the 30S ribosomal subunit. S28E is highly conserved among archaea and eukaryotes. S28E may control...; cd04457" /db_xref="CDD:239904" Site order(13,29,41,43) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:239904" CDS 1..67 /gene="RPS28B" /locus_tag="YLR264W" /gene_synonym="RPS33B" /coded_by="NM_001182151.1:1..204" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:24492965]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S28, no bacterial homolog; has an extraribosomal function in autoregulation, in which Rps28Bp binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; RPS28B has a paralog, RPS28A, that arose from the whole genome duplication" /db_xref="GeneID:850969" /db_xref="SGD:S000004254" ORIGIN 1 mdsktpvtla kvikvlgrtg srggvtqvrv efledtsrti vrnvkgpvre ndilvlmese 61 rearrlr // LOCUS NP_878129 38 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR264C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878129 VERSION NP_878129.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184638.1 REFERENCE 1 (residues 1 to 38) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 38) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 38) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 38) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 38) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 38) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 38) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 38) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 38) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09578. Method: conceptual translation. FEATURES Location/Qualifiers source 1..38 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..38 /product="uncharacterized protein" /calculated_mol_wt="4390" CDS 1..38 /locus_tag="YLR264C-A" /coded_by="NM_001184638.1:1..117" /note="hypothetical protein" /db_xref="GeneID:1466417" /db_xref="SGD:S000028808" ORIGIN 1 mnvifklylt idapkkkkvt vrdflsirys mpyrlasn // LOCUS NP_013367 342 aa linear PLN 30-JUN-2025 DEFINITION Nej1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013367 VERSION NP_013367.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182152.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09579. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..342 /product="Nej1p" /calculated_mol_wt="38985" Region 14..183 /region_name="XLF" /note="XLF-Cernunnos, XRcc4-like factor, NHEJ component; pfam09302" /db_xref="CDD:462749" CDS 1..342 /gene="NEJ1" /locus_tag="YLR265C" /gene_synonym="LIF2" /coded_by="NM_001182152.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11676923]" /experiment="EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:21149442]" /experiment="EXISTENCE:direct assay:GO:0035861 site of double-strand break [PMID:21149442]" /experiment="EXISTENCE:direct assay:GO:0045027 DNA end binding [PMID:21149442]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:11676923|PMID:18245831|PMID:31390569]" /experiment="EXISTENCE:mutant phenotype:GO:0035825 homologous recombination [PMID:31390569]" /experiment="EXISTENCE:mutant phenotype:GO:0045002 double-strand break repair via single-strand annealing [PMID:19571008]" /experiment="EXISTENCE:mutant phenotype:GO:0045027 DNA end binding [PMID:31390569]" /experiment="EXISTENCE:physical interaction:GO:0032807 DNA ligase IV complex [PMID:17567543]" /note="DNA end-binding protein required for nonhomologous end joining (NHEJ); subunit of the DNA ligase IV complex involved in initial end binding, intermolecular ligation, and DNA ligase reactivation after completion of repair; phosphorylation by Tpk1p is required for DNA damage induced NHEJ and for nuclear targeting of Nej1p and Lif1p; human homolog NHEJ1 is phosphorylated by human Tpk1p homolog PRKACB, regulating NHEJ; transcriptionally repressed by MAT heterozygosity" /db_xref="GeneID:850970" /db_xref="SGD:S000004255" ORIGIN 1 mdselkgqql sdaewcvkki ngegnclllf lpmsspttiv mivlvslerl vpyvfklsqt 61 qlsqqcqsqg ftdsislnli klklmdilqa pqeinqiglv dsnlvfsfdv saditvsins 121 vpshvtkdmf ymilqslcml llklvnlstq yhyvqrdiln ekqkcldfll islrdldggs 181 kvisqwapen sknyeslqqc tdddiikkll hkgkfqhqef ladslktlls lrnkfqdvsr 241 feesgelnkk ervrfpavnh fynddfelqa dptnearpns rgkikpktdf kpksressts 301 sqlrlenfse seatpektks ssslveeypq kkrkfgkvri kn // LOCUS NP_013368 701 aa linear PLN 30-JUN-2025 DEFINITION Pdr8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013368 VERSION NP_013368.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182153.1 REFERENCE 1 (residues 1 to 701) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 701) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 701) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 701) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 701) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09580. Method: conceptual translation. FEATURES Location/Qualifiers source 1..701 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..701 /product="Pdr8p" /calculated_mol_wt="81143" Region 25..68 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(26,30,35..38,40,43,53) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(31,34,41,48,51,59) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 188..459 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..701 /gene="PDR8" /locus_tag="YLR266C" /coded_by="NM_001182153.1:1..2106" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12529331]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12529331]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:12529331]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12529331]" /note="Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon; PDR8 has a paralog, YRR1, that arose from the whole genome duplication" /db_xref="GeneID:850971" /db_xref="SGD:S000004256" ORIGIN 1 mdgshfpmks ttgepvssgk kgkrrkviks cafcrkrklk csqarpmcqq cvirklpqcv 61 yteefnypls ntelfeqvpn valvqkienl qtllkendnn nakpvycrss enplrslrts 121 vlgdngsryv fgptswktls lfeqnkfqte fqnlwkvlkp lpectksqln endvvadlps 181 fpqmesciks ffagplfgil hifnqddils lldrlfirdt tdknlvilld lqgnakdkyn 241 lgivlqilcl gyynqdipss vshflhtlsa aslsssssnf veklqfflls yisvminctd 301 gvwdatqgvd linelcqgci slglndidkw ylneseetkq nlrciwfwal fldvstsydi 361 gnppsisddl ldlsiftaqn fqspsidfrr vklmhdfldv srfttreihk remneklttf 421 slrliefiqs nfspiehytn svyysdidpf dililsrsls ivasiyniem iiaqqsriid 481 knrmvqflli sisvcvntmv fhfkepindq envlteglkl siilinplli rivsqvysla 541 fnrlifreka flflidldtg kkiqfikyee enfdelltgf dvrtdkflsf sgtiirfyei 601 idsifavner nkrllkavsn fyqltstlaf ervsrvlfdk asqarietek iwlkkginme 661 hfsdlmiedf indvwktfke iskdlwsidk kkfykqyhfd l // LOCUS NP_013369 570 aa linear PLN 30-JUN-2025 DEFINITION Bop2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013369 VERSION NP_013369.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182154.1 REFERENCE 1 (residues 1 to 570) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 570) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 570) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 570) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 570) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09581. Method: conceptual translation. FEATURES Location/Qualifiers source 1..570 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..570 /product="Bop2p" /calculated_mol_wt="66213" CDS 1..570 /gene="BOP2" /locus_tag="YLR267W" /coded_by="NM_001182154.1:1..1713" /note="hypothetical protein" /db_xref="GeneID:850972" /db_xref="SGD:S000004257" ORIGIN 1 mvaaltylpt eliqrifeft vvetdsqywl ynlvalidfs vssrgggsit edfltnyvrk 61 nlmvldltce atqdsilrae ygflkrllpy idmdaqyirv vdletnadka qnlkaekliv 121 ifdefsdlkl ietffplans nsniiefvfc vrnikssfys pleklhiani vadidintly 181 ldfvdsniys dqnffgifdp difqlinkny rnffsktnek gkkrppickk icfpfvetln 241 ldymaldsff nsilhklttk iktfernnef dvdknlnlns tttvaaliik silqqffnnf 301 hisfpnlvtl nfikmstypn nneitqccnf idlssyvlnk clsenisinf lfqlhslknw 361 smpkikeftg hkfkydettf sgsperyiks lrgnikilqe mainetndgt cyfrvklipe 421 gvektqiinw ipftssfsdd tfkqrhhlkr pmiclknnsl rsltvkiiri ekcssiriqg 481 fylpnlqelf inntlcdttq hqkqasndms cieftswnel pqckklgfaq leddsnyvln 541 isnlqdhlpn ldlresfptf fdirqkfvvv // LOCUS NP_013370 214 aa linear PLN 30-JUN-2025 DEFINITION SNAP receptor SEC22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013370 VERSION NP_013370.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182155.1 REFERENCE 1 (residues 1 to 214) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 214) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 214) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 214) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09582. Method: conceptual translation. FEATURES Location/Qualifiers source 1..214 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..214 /product="SNAP receptor SEC22" /calculated_mol_wt="24927" Region 2..192 /region_name="SNC1" /note="Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]; COG5143" /db_xref="CDD:227472" CDS 1..214 /gene="SEC22" /locus_tag="YLR268W" /gene_synonym="SLY2; TS26; TSL26" /coded_by="NM_001182155.1:1..645" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11001058]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:9580559]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:9580559]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0012507 ER to Golgi transport vesicle membrane [PMID:8500167]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:1903839]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:11001058]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:12221135]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:9813082]" /experiment="EXISTENCE:mutant phenotype:GO:0048280 vesicle fusion with Golgi apparatus [PMID:12221135]" /experiment="EXISTENCE:physical interaction:GO:0005484 SNAP receptor activity [PMID:12853481]" /note="R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog" /db_xref="GeneID:850973" /db_xref="SGD:S000004258" ORIGIN 1 mikstliyre dglplctsvd nendpslfeq kqkvkivvsr ltpqsateat lesgsfeihy 61 lkksmvyyfv icesgyprnl afsylndiaq efehsfaney pkptvrpyqf vnfdnflqmt 121 kksysdkkvq dnldqlnqel vgvkqimskn iedllyrgds ldkmsdmsss lketskryrk 181 saqkinfdll isqyapiviv afffvflfww iflk // LOCUS NP_013372 350 aa linear PLN 30-JUN-2025 DEFINITION 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013372 VERSION NP_013372.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182157.1 REFERENCE 1 (residues 1 to 350) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 350) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 350) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 350) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09583. Method: conceptual translation. FEATURES Location/Qualifiers source 1..350 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..350 /product="5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase" /EC_number="3.6.1.59" /calculated_mol_wt="40639" Region 1..330 /region_name="COG5075" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227407" CDS 1..350 /gene="DCS1" /locus_tag="YLR270W" /coded_by="NM_001182157.1:1..1053" /experiment="EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:12198172]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:16963086]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [PMID:12198172]" /experiment="EXISTENCE:direct assay:GO:0044692 exoribonuclease activator activity [PMID:22570495]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:15240832]" /experiment="EXISTENCE:genetic interaction:GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [PMID:16260594]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:12198172]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:15240832]" /experiment="EXISTENCE:mutant phenotype:GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [PMID:12198172]" /experiment="EXISTENCE:mutant phenotype:GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [PMID:16260594]" /note="Non-essential hydrolase involved in mRNA decapping; activates Xrn1p; may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; acts as inhibitor of neutral trehalase Nth1p; required for growth on glycerol medium; protein abundance increases in response to DNA replication stress; DCS1 has a paralog, DCS2, that arose from the whole genome duplication" /db_xref="GeneID:850974" /db_xref="SGD:S000004260" ORIGIN 1 msqlptdfas likrfqfvsv ldsnpqtkvm sllgtidnkd aiitaekthf lfdetvrrps 61 qdgrstpvly nceneyscin giqelkeits ndiyywglsv ikqdmesnpt aklnliwpat 121 pihikkyeqq nfhlvretpe mykrivqpyi eemcnngrlk wvnnilyega eservvykdf 181 seenkddgfl ilpdmkwdgm nldslylvai vyrtdiktir dlrysdrqwl inlnnkirsi 241 vpgcynyavh pdelrilvhy qpsyyhfhih ivnikhpglg nsiaagkail lediiemlny 301 lgpegymnkt ityaigenhd lwkrgleeel tkqlerdgip kipkivngfk // LOCUS NP_013373 274 aa linear PLN 30-JUN-2025 DEFINITION Cmg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013373 VERSION NP_013373.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182158.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09584. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..274 /product="Cmg1p" /calculated_mol_wt="31873" Region 42..85 /region_name="G-patch" /note="G-patch domain; pfam01585" /db_xref="CDD:396249" Region 224..273 /region_name="DUF4187" /note="Domain of unknown function (DUF4187); pfam13821" /db_xref="CDD:463989" CDS 1..274 /gene="CMG1" /locus_tag="YLR271W" /coded_by="NM_001182158.1:1..825" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:850976" /db_xref="SGD:S000004261" ORIGIN 1 meesktkrke dridlkntpp qkkskrdstn detartslrs imprgykmme nmgykegetl 61 gsnesalkep ikveintkrr giraekpdps tmndmqmseq rfikresemk nnkrlkkiwy 121 riqkvafemm gdsdlynpge dprdfnvlwr syvmqlneev akndlnnhsn ndnedknnmi 181 pmvnesleas paikgekfgr pstlidcdts iigsritkdt elaeleelsi ekritklnif 241 lrsekyycff cgikykdegd lyehcpgvne ddhk // LOCUS NP_013374 1176 aa linear PLN 30-JUN-2025 DEFINITION condensin subunit YCS4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013374 VERSION NP_013374.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182159.1 REFERENCE 1 (residues 1 to 1176) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1176) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1176) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1176) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09585. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1176 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1176 /product="condensin subunit YCS4" /calculated_mol_wt="132837" Region 1..1171 /region_name="COG5098" /note="Chromosome condensation complex Condensin, subunit D2 [Chromatin structure and dynamics / Cell division and chromosome partitioning]" /db_xref="CDD:227429" Region 313..342 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 351..384 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 943..965 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 977..1006 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..1176 /gene="YCS4" /locus_tag="YLR272C" /gene_synonym="LOC7" /coded_by="NM_001182159.1:1..3531" /experiment="EXISTENCE:direct assay:GO:0000796 condensin complex [PMID:10811823]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11854418]" /experiment="EXISTENCE:genetic interaction:GO:0003682 chromatin binding [PMID:11864994]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:11854418|PMID:11864994]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:11864994|PMID:11854418]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:14662740]" /experiment="EXISTENCE:mutant phenotype:GO:0010032 meiotic chromosome condensation [PMID:14662740]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11854418]" /experiment="EXISTENCE:mutant phenotype:GO:0043007 maintenance of rDNA [PMID:17203076]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:31553911]" /experiment="EXISTENCE:mutant phenotype:GO:0051307 meiotic chromosome separation [PMID:14662740]" /experiment="EXISTENCE:mutant phenotype:GO:0070058 tRNA gene clustering [PMID:18708579]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:31553911]" /experiment="EXISTENCE:mutant phenotype:GO:1903342 negative regulation of meiotic DNA double-strand break formation [PMID:25103240]" /note="Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus; required for replication slow zone (RSZ) breakage following Mec1p inactivation" /db_xref="GeneID:850977" /db_xref="SGD:S000004262" ORIGIN 1 msgfslseyl tkfqttdres yprlqdpsre lnviidqlav speqidaspd slealidlch 61 dfphltpklq tqlsylisss lsnlskdika nlssnvnfte igglipqwkr hleeygyliq 121 vlltflqdel hkvssqstnl nrsaknsknd sanvelfkrd cnqmenlles itklleinls 181 kifqttpekd lfiglftrpl fvlleiepvt kvsslkmfiq rilamcvknh gqsssiqssl 241 mtnltyflhl svfnaellkl lndeynypql tedilkeist rvfnakdttg pkaisnflik 301 lselspgiml rqmnlvitll nnssitlrcs vveacgniva elaqdpqtme hykqqiavli 361 elleerfqds npyvrtkaiq gcskicdlss kfnkskakft slavrslqdr sslvrrnsvk 421 llsklllkhp fkaihgsqlr lseweeylkg sesqlnstlk kvesqetlnd tierslieee 481 veqdegqcrt elegsfnksa elsrieneve ninatntsvl mklklmivyy kdaisfikei 541 hksielisnl lfsknrnevl esmdflvlad afdielsefg ikkmlhlvwm kgtndegtsi 601 svhliecykq lfltapdscn mqekaahiak nlinlsigas iadlasleql lgmmyeqkli 661 dqhvinilwa iynsaskasm qkeqnvnnrd sekgfskeqi hgsiiilgml sladneialk 721 glesllnigl gavglkdltl crysclaler mvpkrstiit kainqeledv avkklyaiii 781 nytkdneyyp mceqalsalf tisskpdila tdlirektmm tfgkpeeeds ilsleqssrv 841 vslsqllfiv gqvaiktlvy lekceaefkk rkieaetrng kvknqgadvt nttqdnggdk 901 elemiggtne ddftdaiqfv kenellfgek silgkfcpiv eeivsnssrf sdpmlqrtat 961 lcleklmcls skycekslpl litvmekspd ptirsnavlg lgdmavcfnn lvdentdyly 1021 rrlhdenlmv qrtclmtvtf lilagqvkvk gqlgemakcl dnpdqgisdm crlfftelas 1081 kdnaiyngfi difsnlssdd llgkesfkki ikflltfidk erhqkqlnek lvgrlrkcet 1141 qkqwddiafv lnnlpykned vtalleqgfk vvsake // LOCUS NP_013375 648 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase regulator PIG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013375 VERSION NP_013375.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182160.1 REFERENCE 1 (residues 1 to 648) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 648) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 648) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 648) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09586. Method: conceptual translation. FEATURES Location/Qualifiers source 1..648 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..648 /product="protein phosphatase regulator PIG1" /calculated_mol_wt="74015" Region 192..330 /region_name="CBM_21" /note="Carbohydrate/starch-binding module (family 21); pfam03370" /db_xref="CDD:427265" CDS 1..648 /gene="PIG1" /locus_tag="YLR273C" /coded_by="NM_001182160.1:1..1947" /experiment="EXISTENCE:genetic interaction:GO:0005979 regulation of glycogen biosynthetic process [PMID:9046081]" /experiment="EXISTENCE:genetic interaction:GO:0019888 protein phosphatase regulator activity [PMID:9046081]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:9046081]" /note="Putative targeting subunit for type-1 protein phosphatase Glc7p; tethers Glc7p to Gsy2p glycogen synthase; PIG1 has a paralog, GAC1, that arose from the whole genome duplication" /db_xref="GeneID:850979" /db_xref="SGD:S000004263" ORIGIN 1 mpyshgkklk pslklaktis tssfvsstts nsfspledst sassstssss sgksvrfaah 61 lytvkkfntk lapisiseka asnltrnlhn naipltfpfi ggedhrysld ildysdleyd 121 nkdveydnes dvednamlmh drsmfiekei lcfgeeetfd madwklvsnn lnpfksdykv 181 dvtgledkif kylngqnikv hslelsdpvs yedicsnnfg ncqiwglifv nnlnfekkie 241 ikftlnnwad ihyinahynk svtphvdefk fiidisalkl nlisknliyt nfferkttcl 301 lnlqfccryd vngfeyrsfy dnndyknyei tislsainln ravsnssifn snlgpskmga 361 snaevtmskn nenskkplrk fikdtdyynd splkhkfyqs fetkaackte pvsqtfkaet 421 idceiepfny ffeppdsqtn edmsdssydl slqdfnywef snhglgkala dsdilqfkny 481 pkpepfsrpp iiddtftlnt ddrtlgsktq klednlakew ksaktrttln etplhddehr 541 tsftyttwnn stdtlmkrke erpvesascs qlsiatikae edllyqdyin sgressspei 601 splntttslp ffpgdnmsds sgeyeertsl spnkihifrd yfykspsp // LOCUS NP_013376 775 aa linear PLN 30-JUN-2025 DEFINITION MCM DNA helicase complex subunit MCM5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013376 VERSION NP_013376.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182161.1 REFERENCE 1 (residues 1 to 775) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 775) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 775) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 775) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 775) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 775) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 775) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 775) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 775) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09587. Method: conceptual translation. FEATURES Location/Qualifiers source 1..775 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..775 /product="MCM DNA helicase complex subunit MCM5" /EC_number="3.6.4.12" /calculated_mol_wt="86280" Region 29..102 /region_name="MCM_N" /note="MCM N-terminal domain; pfam14551" /db_xref="CDD:464206" Region 144..689 /region_name="MCM" /note="minichromosome maintenance proteins; smart00350" /db_xref="CDD:214631" Site order(377,398,400..404,406,417..419,423..424,427,438,440, 444..447,455..457,461..467,470..471,481,488,495,499,501, 503,505..507,510..512,528,542,545,549,558,560,565,569, 573..574,576..578,596,614,619..620,623,626..627,630..631, 650,653,657) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:350662" Site order(377..379,418..424,499,549,568,575,650..651) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350662" Site order(453,455,506..507) /site_type="other" /note="nucleic acid binding site [nucleotide binding]" /db_xref="CDD:350662" CDS 1..775 /gene="MCM5" /locus_tag="YLR274W" /gene_synonym="BOB1; CDC46" /coded_by="NM_001182161.1:1..2328" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:19005221]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10075735|PMID:9159120]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:11756674|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:2279699]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:9335335|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:2279699]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:19318354]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:18657510]" /experiment="EXISTENCE:direct assay:GO:0042555 MCM complex [PMID:12480933]" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:17895243]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:2279699]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:9990508]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:12750362]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16980387]" /experiment="EXISTENCE:mutant phenotype:GO:0033260 nuclear DNA replication [PMID:2044962]" /experiment="EXISTENCE:physical interaction:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /note="Component of the Mcm2-7 hexameric helicase complex; MCM complex is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase" /db_xref="GeneID:850980" /db_xref="SGD:S000004264" ORIGIN 1 msfdrpeiys apvlqgespn dddnteiiks fknfilefrl dsqfiyrdql rnnilvknys 61 ltvnmehlig ynediykkls depsdiiplf etaitqvakr isilsraqsa nnndkdpent 121 smdtdsllln slptfqliln snanqiplrd ldsehvskiv rlsgiiists vlssratyls 181 imcrncrhtt sitinnfnsi tgntvslprs clstiesess manesnigde stkkncgpdp 241 yiiihesskf idqqflklqe ipelvpvgem prnltmtcdr yltnkvipgt rvtivgiysi 301 ynskngagsg rsgggnggsg vairtpyiki lgiqsdvets siwnsvtmft eeeeeeflql 361 srnpklyeil tnsiapsifg nedikkaivc llmggskkil pdgmrlrgdi nvlllgdpgt 421 aksqllkfve kvspiavyts gkgssaaglt asvqrdpmtr efyleggamv ladggvvcid 481 efdkmrdedr vaiheameqq tisiakagit tvlnsrtsvl aaanpiygry ddlkspgdni 541 dfqttilsrf dmifivkddh neerdisian hvinihtgna namqnqqeen gseisiekmk 601 ryitycrlkc aprlspqaae klssnfvtir kqllineles terssipiti rqleaiirit 661 eslaklelsp iaqerhvdea irlfqastmd aasqdpiggl nqasgtslse irrfeqelkr 721 rlpigwstsy qtlrrefvdt hrfsqlaldk alyalekhet iqlrhqgqni yrsgv // LOCUS NP_013377 110 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SMD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013377 VERSION NP_013377.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182162.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09588. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..110 /product="mRNA splicing protein SMD2" /calculated_mol_wt="12722" Region 27..108 /region_name="Sm_D2" /note="Sm protein D2; cd01720" /db_xref="CDD:212467" Site order(27,30..31,49..51,63..64,66,97,99) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:212467" Site order(33,41,47..51,58..59,62..66,70..71,74..75,87..89,91, 93..99,101..107) /site_type="other" /note="heptamer interface [polypeptide binding]" /db_xref="CDD:212467" Site order(44..50,52..64,66..70) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212467" Site 93..104 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212467" CDS 1..110 /gene="SMD2" /locus_tag="YLR275W" /coded_by="NM_001182162.1:1..333" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720285|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9012791|PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /note="Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2" /db_xref="GeneID:850981" /db_xref="SGD:S000004265" ORIGIN 1 mssqiidrpk helsraelee leefefkhgp mslindamvt rtpviislrn nhkiiarvka 61 fdrhcnmvle nvkelwtekk gknvinrerf isklflrgds vivvlktpve // LOCUS NP_013378 594 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent DNA/RNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013378 VERSION NP_013378.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182163.1 REFERENCE 1 (residues 1 to 594) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 594) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 594) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 594) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09589. Method: conceptual translation. FEATURES Location/Qualifiers source 1..594 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..594 /product="ATP-dependent DNA/RNA helicase" /EC_number="3.6.4.13" /calculated_mol_wt="67929" Region 24..235 /region_name="DEADc_DDX56" /note="DEAD-box helicase domain of DEAD box protein 56; cd17961" /db_xref="CDD:350719" Site order(36..37,39..41,44,63..70) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350719" Region 247..427 /region_name="SF2_C_DEAD" /note="C-terminal helicase domain of the DEAD box helicases; cd18787" /db_xref="CDD:350174" Site order(386,388,413,416..417) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350174" CDS 1..594 /gene="DBP9" /locus_tag="YLR276C" /coded_by="NM_001182163.1:1..1785" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:15028736]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:15028736]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11565753]" /experiment="EXISTENCE:direct assay:GO:0033677 DNA/RNA helicase activity [PMID:15028736]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11565753]" /note="DEAD-box protein required for 27S rRNA processing; exhibits DNA, RNA and DNA/RNA helicase activities; ATPase activity shows preference for DNA over RNA; DNA helicase activity abolished by mutation in RNA-binding domain" /db_xref="GeneID:850982" /db_xref="SGD:S000004266" ORIGIN 1 msyekksveg ayiddsttfe afhldsrllq aiknigfqyp tliqshaipl alqqkrdiia 61 kaatgsgktl aylipvieti leykktidng eengtlgiil vptrelaqqv ynvleklvly 121 cskdirtlni ssdmsdsvls tllmdqpeii vgtpgklldl lqtkinsisl nelkflvvde 181 vdlvltfgyq ddlnkigeyl plkknlqtfl msatlnddiq alkqkfcrsp ailkfndeei 241 nknqnkllqy yvkvsefdkf llcyvifkln likgktlifv nnidrgyrlk lvmeqfgiks 301 cilnselpvn srqhivdqfn knvyqlliat ddteyikeed deieeghnte nqeekslege 361 pendkkpskk kkvqvkkdke ygvsrgvdfk nvacvlnfdl pttaksyvhr vgrtarggkt 421 gtaisfvvpl kefgkhkpsm lqtakkderi lsriikqqsk lglelqpykf dqkqveafry 481 rmedgfravt qvairearvk elkqellase klkrhfeenp kelqslrhdk elhparvqqh 541 lkrvpdyllp esargngtkv kfvpfhnakk rhshkkgrvs kpkngkvdpl knfk // LOCUS NP_013379 779 aa linear PLN 30-JUN-2025 DEFINITION cleavage polyadenylation factor subunit YSH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013379 VERSION NP_013379.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182164.1 REFERENCE 1 (residues 1 to 779) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 779) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 779) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 779) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 779) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09590. Method: conceptual translation. FEATURES Location/Qualifiers source 1..779 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..779 /product="cleavage polyadenylation factor subunit YSH1" /calculated_mol_wt="87543" Region 9..210 /region_name="CPSF3-like_MBL-fold" /note="cleavage and polyadenylation specificity factor (CPSF) subunit 3 and related proteins; MBL-fold metallo-hydrolase domain; cd16292" /db_xref="CDD:293850" Region 14..432 /region_name="YSH1" /note="RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]; COG1236" /db_xref="CDD:440849" Site order(68,70,72..73,163,184) /site_type="active" /db_xref="CDD:293850" Region 533..777 /region_name="CPSF73-100_C" /note="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term; pfam11718" /db_xref="CDD:463330" CDS 1..779 /gene="YSH1" /locus_tag="YLR277C" /gene_synonym="BRR5" /coded_by="NM_001182164.1:1..2340" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:10523662|PMID:12819204]" /experiment="EXISTENCE:mutant phenotype:GO:0004521 RNA endonuclease activity [PMID:15037765]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:18971324]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:18971324]" /experiment="EXISTENCE:mutant phenotype:GO:0008380 RNA splicing [PMID:18971324]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:18971324]" /experiment="EXISTENCE:mutant phenotype:GO:0034247 snoRNA splicing [PMID:18971324]" /note="Endoribonuclease; subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs; protein abundance increases in response to DNA replication stress; YSH1 has a paralog, SYC1, that arose from the whole genome duplication" /db_xref="GeneID:850983" /db_xref="SGD:S000004267" ORIGIN 1 mertntttfk ffslggsnev grschilqyk gktvmldagi hpayqglasl pfydefdlsk 61 vdillishfh ldhaaslpyv mqrtnfqgrv fmthptkaiy rwllrdfvrv tsigsssssm 121 gtkdeglfsd edlvdsfdki etvdyhstvd vngikftafh aghvlgaamf qieiaglrvl 181 ftgdysrevd rhlnsaevpp lssnvlives tfgtathepr lnrerkltql ihstvmrggr 241 vllpvfalgr aqeimlilde ywsqhadelg ggqvpifyas nlakkcmsvf qtyvnmmndd 301 irkkfrdsqt npfifknisy lrnledfqdf gpsvmlaspg mlqsglsrdl lerwcpedkn 361 lvlitgysie gtmakfimle pdtipsinnp eitiprrcqv eeisfaahvd fqenlefiek 421 isapniilvh geanpmgrlk sallsnfasl kgtdnevhvf nprncvevdl efqgvkvaka 481 vgnivneiyk eenveikeei aakiepikee nednldsqae kglvdeeehk divvsgilvs 541 ddknfeldfl slsdlrehhp dlsttilrer qsvrvnckke liywhilqmf geaevlqddd 601 rvtnqepkvk eeskdnltnt gklilqimgd ikltivntla vvewtqdlmn dtvadsiiai 661 lmnvdsapas vklsshscdd hdhnnvqsna qgkideverv kqisrlfkeq fgdcftlfln 721 kdeyasnkee titgvvtigk stakidfnnm kilecnsnpl kgrvesllni ggnlvtplc // LOCUS NP_013380 1341 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR278C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013380 VERSION NP_013380.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182165.1 REFERENCE 1 (residues 1 to 1341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1341) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09591. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1341 /product="uncharacterized protein" /calculated_mol_wt="151148" Region 35..>69 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(40,45..48,50,53,63) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(41,44,51,58,61,68) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 308..730 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..1341 /locus_tag="YLR278C" /coded_by="NM_001182165.1:1..4026" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /note="Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; associates with rDNA chromatin in vivo; YLR278C is not an essential gene" /db_xref="GeneID:850984" /db_xref="SGD:S000004268" ORIGIN 1 mgrprknvsq ekiqqlkrel elagnrtdvl lqdkkgrsrs cllcrrrkqr cdhklpscta 61 clkagikcvq pskyssstsn sntnnntpta gtvpptphpv ikrelqdssi gagagaatsl 121 ndmtiikpis tsnsnvdagd anefrktiks vttnsnpnlm rqdkdqytif lekklkslet 181 lldlspgcnq ynyelsqykk vshlfsnnts dysrpnssnm vilplpspsn kplentnnng 241 snvnaatndt sastnninnn naicqsasll ndpletldft kcifakynlk keflmydpif 301 elneklsrsf ldtfftrlqf kypildeqei ytfydhylhn kilippsspa tssaappsns 361 hsyseiefhf lsgrmwlvfs isayllmttg kykgfpphry fstairhitk cglhlnyvqq 421 ielltllvly iirtdrdsli lydiikdvmg iskkklhlnq wypndpfank klrlfwcvyl 481 lermicvavg kpytikesei nlplfnndsf ytkgvhaaap stndhgvqfi nqslklrrie 541 sqfvetlqll kndsrsvkqs idqlplvrkf fedlevwrks ystldvknfe netlklyyyr 601 svrlliqpyl effapedrlf recqaaagqi cqlykifhqk tlnghstpav htvfvagvtl 661 iycmwlarnf ddqrrkklgd askhtrplis aslfstmddl racsvclyvm tersnfartf 721 rdtfdqlmna tvgnliercg pdsselifma ssvakrtepk nindeankai ssgdtlhdsn 781 sanaanlsns ndknishngg mppavarifg kgqaeehagf vensqvdlae qekfkkkqgv 841 lektsvpksl ahlltkmddr srisnssmsy ttssssssss ssssstlsfp ssqeknlkin 901 vnndnngmti ssvnrehnnn hnnnndnnnn nnnnnnnsnn nnnvnnndne snsrsttnns 961 cnngnnsqyv rnnnvtmend verpiqdqyi vkkptnqtef dwqvfqqqaf lqqqlaqhnl 1021 qaylsslntd tmtnrspsks ssistasshs dpipiamtqs ptpypqtsnm lpqqhvsrpl 1081 pqqqreqpqq hitspqrfse snftnqlnng minsnplqsa ifsnhtsenk qlrdveesnf 1141 stsplradyg nniissipas ftsnsipvsv kqarngsssg dilfsngahd minnistwtn 1201 nsvldalnsk silqtifpqs qepsslsmdk qqqqhqqqnm csennvtann fqqtqndpsy 1261 nrnlfmmsnq egvqynldet ekngpktqve antsanlhfd nviptvtnad irkkrsnwdn 1321 mmtsgpvedf wtinddygfl t // LOCUS NP_013383 155 aa linear PLN 30-JUN-2025 DEFINITION Rso55p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013383 VERSION NP_013383.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182168.1 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09592. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..155 /product="Rso55p" /calculated_mol_wt="18066" Region 47..>95 /region_name="RF-1" /note="RF-1 domain; pfam00472" /db_xref="CDD:459823" CDS 1..155 /gene="RSO55" /locus_tag="YLR281C" /gene_synonym="PTH3" /coded_by="NM_001182168.1:1..468" /experiment="EXISTENCE:direct assay:GO:0004045 peptidyl-tRNA hydrolase activity [PMID:33686140]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:33686140]" /note="Stalled-ribosome rescue factor srRF2; mitochondrial protein required for respiratory growth in presence of bacteriostatic ribosome-binding antibiotics; not an essential gene" /db_xref="GeneID:850987" /db_xref="SGD:S000004271" ORIGIN 1 mmrgaskrsi ssaavllikk nklpprpkft pemeaqctek flhggrgpgg qkinkcnskv 61 qlrheptgiv vecqetrsre qnrklarlkl arelaasydt mpsreeallq whrqqkrsqr 121 rrsvakyeqr eeaarvekee reardremvr elfrr // LOCUS NP_013385 314 aa linear PLN 30-JUN-2025 DEFINITION Put7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013385 VERSION NP_013385.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182170.1 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09593. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..314 /product="Put7p" /calculated_mol_wt="36443" Region 103..270 /region_name="CCDC90-like" /note="Coiled-coil domain-containing protein 90-like; pfam07798" /db_xref="CDD:462268" CDS 1..314 /gene="PUT7" /locus_tag="YLR283W" /coded_by="NM_001182170.1:1..945" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:32978391]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:2000214 regulation of proline metabolic process [PMID:32978391]" /note="Regulator of mitochondrial proline metabolism; tethered with Fmp32p to inner mitochondrial membrane in large hetero-oligomeric complex, abundance of which is regulated by proline; involved in mitochondrial proline homeostasis and cellular redox balance; null exhibits pronounced defect in proline utilization, and can be functionally complemented by expression of human homolog MCUR1" /db_xref="GeneID:850988" /db_xref="SGD:S000004273" ORIGIN 1 mmrlirtlpl rcfktrirrq gsllclrcfs syskpllqks mslkniqlsd lsssplsknk 61 ekqekpeken egkhsiglld rfsedfitqg nglkpttsqn qldtikfyqm lrergnfsde 121 qckiiialll qllndqfysc yndlflrdme lnkqshlfss letelkfaiq nsrdtqlneh 181 hlqllklkre lnsihdelne iiidllqkda klefnnqkle ntllyrqlnl klndcsnkiq 241 tkilgdirsh ienlrwqttr sgllvilvlv csimigvsas kkerpglqep eepeilapke 301 didttfpqdq hdid // LOCUS NP_013386 280 aa linear PLN 30-JUN-2025 DEFINITION dodecenoyl-CoA isomerase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013386 VERSION NP_013386.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182171.1 REFERENCE 1 (residues 1 to 280) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 280) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 280) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 280) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09594. Method: conceptual translation. FEATURES Location/Qualifiers source 1..280 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..280 /product="dodecenoyl-CoA isomerase" /EC_number="5.3.3.8" /calculated_mol_wt="31567" Region 11..219 /region_name="crotonase-like" /note="Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558" /db_xref="CDD:119339" Site order(30,32,64,68..72,122,124..126,149..150,153) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:119339" Site order(70,126) /site_type="active" /note="oxyanion hole (OAH) forming residues [active]" /db_xref="CDD:119339" Site order(106,114,135..138,151..154,160,162..164,166..167, 172..173,175..176,178..179,182,193,196,216,219) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:119339" CDS 1..280 /gene="ECI1" /locus_tag="YLR284C" /coded_by="NM_001182171.1:1..843" /experiment="EXISTENCE:direct assay:GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity [PMID:9813046|PMID:9837886]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:9813046|PMID:9837886]" /experiment="EXISTENCE:direct assay:GO:0006635 fatty acid beta-oxidation [PMID:9813046|PMID:9837886]" /experiment="EXISTENCE:mutant phenotype:GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity [PMID:9837886|PMID:9813046]" /note="Peroxisomal delta3,delta2-enoyl-CoA isomerase; hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced; ECI1 has a paralog, DCI1, that arose from the whole genome duplication" /db_xref="GeneID:850990" /db_xref="SGD:S000004274" ORIGIN 1 msqeirqnek isyriegpff iihlmnpdnl nalegedyiy lgelleladr nrdvyftiiq 61 ssgrffssga dfkgiakaqg ddtnkypset skwvsnfvar nvyvtdafik hskvliccln 121 gpaiglsaal valcdivysi ndkvyllypf anlglitegg ttvslplkfg tnttyeclmf 181 nkpfkydimc engfisknfn mpssnaeafn akvleelrek vkglylpscl gmkkllksnh 241 idafnkansv evneslkywv dgeplkrfrq lgskqrkhrl // LOCUS NP_013387 261 aa linear PLN 30-JUN-2025 DEFINITION S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013387 VERSION NP_013387.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182172.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09595. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..261 /product="S-adenosylmethionine-dependent methyltransferase" /calculated_mol_wt="29502" Region <56..231 /region_name="Nnt1" /note="Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones]; COG3897" /db_xref="CDD:443104" CDS 1..261 /gene="NNT1" /locus_tag="YLR285W" /gene_synonym="EFM7" /coded_by="NM_001182172.1:1..786" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:21858014]" /experiment="EXISTENCE:direct assay:GO:0016279 protein-lysine N-methyltransferase activity [PMID:26545399]" /experiment="EXISTENCE:direct assay:GO:0071885 N-terminal protein N-methyltransferase activity [PMID:26545399]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:12736687]" /note="S-adenosylmethionine-dependent methyltransferase; novel N-terminal protein methyltransferase that trimethylates the N-terminal glycine residue (G2) and also dimethylates lysine (K3) on elongation factor eEF1A (Tef1p/Tef2p); has a role in rDNA silencing and in lifespan determination" /db_xref="GeneID:850991" /db_xref="SGD:S000004275" ORIGIN 1 msdieslgea aglfeepedf lppppkphfa eyqrshitke sksdvkdikl rlvgtsplwg 61 hllwnagiyt anhldshpel ikgktvlelg aaaalpsvic alngaqmvvs tdypdpdlmq 121 nidyniksnv pedfnnvste gyiwgndysp llahiekign nngkfdliil sdlvfnhteh 181 hkllqttkdl laekgqalvv fsphrpklle kdleffelak nefhlvpqli emvnwkpmfd 241 edeetievrs rvyayylthe k // LOCUS NP_878130 56 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR285C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878130 VERSION NP_878130.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184567.1 REFERENCE 1 (residues 1 to 56) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 56) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 56) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 56) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09596. Method: conceptual translation. FEATURES Location/Qualifiers source 1..56 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..56 /product="uncharacterized protein" /calculated_mol_wt="7032" CDS 1..56 /locus_tag="YLR285C-A" /coded_by="NM_001184567.1:1..171" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466418" /db_xref="SGD:S000028569" ORIGIN 1 mflrfynrll yiynelfnfl rftvflpfce fvphhdlfyl ivtyqrtlvy khkndc // LOCUS NP_013388 562 aa linear PLN 30-JUN-2025 DEFINITION chitinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013388 VERSION NP_013388.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182173.1 REFERENCE 1 (residues 1 to 562) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 562) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 562) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 562) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09597. Method: conceptual translation. FEATURES Location/Qualifiers source 1..562 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..562 /product="chitinase" /EC_number="3.2.1.14" /calculated_mol_wt="58884" Region 27..306 /region_name="GH18_hevamine_XipI_class_III" /note="This conserved domain family includes xylanase inhibitor Xip-I, and the class III plant chitinases such as hevamine, concanavalin B, and PPL2, all of which have a glycosyl hydrolase family 18 (GH18) domain. Hevamine is a class III endochitinase that...; cd02877" /db_xref="CDD:119356" Site order(32,60,155,157,189,212,214,285) /site_type="active" /db_xref="CDD:119356" Site order(35..36,60,62,70,72..73,109..111,285,289) /site_type="other" /note="substrate-binding cleft [chemical binding]" /db_xref="CDD:119356" Site 157 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:119356" Region <503..539 /region_name="CBM_19" /note="Carbohydrate binding domain (family 19); pfam03427" /db_xref="CDD:112252" CDS 1..562 /gene="CTS1" /locus_tag="YLR286C" /gene_synonym="SCW2" /coded_by="NM_001182173.1:1..1689" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:1918080|PMID:19129178]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11747810]" /experiment="EXISTENCE:direct assay:GO:0008843 endochitinase activity [PMID:6799506]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:1918080|PMID:11747810]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:1918080]" /note="Endochitinase; required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p" /db_xref="GeneID:850992" /db_xref="SGD:S000004276" ORIGIN 1 msllyiillf tqflllptda fdrsantnia vywgqnsagt qeslatyces sdadifllsf 61 lnqfptlgln fanacsdtfs dgllhctqia edietcqslg kkvllslgga sgsylfsdds 121 qaetfaqtlw dtfgegtgas erpfdsavvd gfdfdiennn evgysalatk lrtlfaegtk 181 qyylsaapqc pypdasvgdl lenadidfaf iqfynnycsv sgqfnwdtwl tyaqtvspnk 241 niklflglpg sasaagsgyi sdtsllesti adiassssfg gialwdasqa fsnelngepy 301 veilknllts asqtatttva tsktsaasts sastssasts qkkttqstts tqskskvtls 361 ptassaikts itqttktlts stktksslgt tttestlnsv aitsmkttls sqitsaalvt 421 pqttttsivs sapiqtaits tlspatksss vvslqtatts tlsptttsts sgstssgsts 481 sdstartlak elnaqyaagk lngkstcteg eiacsadgkf avcdhsawvy mecasgttcy 541 aydsgdsvyt qcnfsylesn yf // LOCUS NP_013389 355 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR287C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013389 VERSION NP_013389.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182174.1 REFERENCE 1 (residues 1 to 355) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 355) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 355) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 355) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09598. Method: conceptual translation. FEATURES Location/Qualifiers source 1..355 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..355 /product="uncharacterized protein" /calculated_mol_wt="40797" Region 52..327 /region_name="GCIP" /note="Grap2 and cyclin-D-interacting; pfam13324" /db_xref="CDD:463844" CDS 1..355 /locus_tag="YLR287C" /coded_by="NM_001182174.1:1..1068" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene" /db_xref="GeneID:850993" /db_xref="SGD:S000004277" ORIGIN 1 mstgssdrkd dvkllellns ideqflvpyk kpedlrkiss ttklqgstpt keldklasvl 61 kahctkigiv ckpgtfdnnh kvviteiqnf srplfyllsl fplfynnkdc pkyftdqlde 121 stlqlldglr dfiaelqerl kndenasldk erltsvgkif nacdslsncs kagpygilan 181 ilkdnvaimd dtmneikewl eepdfsansd difldfedse sesdsqkeef dqekvyenik 241 lffdgftrki klikllvstf rktlvskdft pkrnqaetld sihtylkeiq llldevvstv 301 qfepknftne evkeeqaalv avtkkvliqm sklyegdpkr kkwidtweik fnelf // LOCUS NP_013390 63 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS30 RPS30A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013390 VERSION NP_013390.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182175.1 REFERENCE 1 (residues 1 to 63) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 63) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 63) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 63) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09599. Method: conceptual translation. FEATURES Location/Qualifiers source 1..63 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..63 /product="40S ribosomal protein eS30 RPS30A" /calculated_mol_wt="6987" Region 3..60 /region_name="Ribosomal_S30" /note="Ribosomal protein S30; pfam04758" /db_xref="CDD:398432" CDS 1..63 /gene="RPS30A" /locus_tag="YLR287C-A" /coded_by="NM_001182175.1:1..192" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:19470581]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30A has a paralog, RPS30B, that arose from the whole genome duplication" /db_xref="GeneID:850994" /db_xref="SGD:S000004278" ORIGIN 1 makvhgslar agkvksqtpk vektekpkkp kgraykrlly trrfvnvtlv ngkrrmnpgp 61 svq // LOCUS NP_013391 474 aa linear PLN 30-JUN-2025 DEFINITION Mec3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013391 VERSION NP_013391.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182176.1 REFERENCE 1 (residues 1 to 474) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 474) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 474) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 474) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 474) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09600. Method: conceptual translation. FEATURES Location/Qualifiers source 1..474 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..474 /product="Mec3p" /calculated_mol_wt="53015" Region 1..468 /region_name="Hus1" /note="Hus1-like protein; pfam04005" /db_xref="CDD:461127" CDS 1..474 /gene="MEC3" /locus_tag="YLR288C" /gene_synonym="PIP3; PSO9" /coded_by="NM_001182176.1:1..1425" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:10915872]" /experiment="EXISTENCE:direct assay:GO:0030896 checkpoint clamp complex [PMID:12604797|PMID:9670034|PMID:9891048]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:17202155]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:9725831]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:9988274]" /note="DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1" /db_xref="GeneID:850995" /db_xref="SGD:S000004279" ORIGIN 1 mklklivngc eapddykllr ttintvaslr ktailrfnse rltiistpks slnssnngti 61 lrgdtgqlwc tiphdvfrly tvisarelnt itmecncdsl lsvfkrydrv mnqgsssnmt 121 iklqsmpewn tnngtlsggt aggvdttskp npicalgitf eeivhtsgpn daivmnggvd 181 ehnglpttvg tgnllasnkv imhsfkvpvk llfraqdtri qepminyiql mmyklppisg 241 efgsafhgfi rrverysnvn hihlmgvkkk ehgnegddve lkiivneldw hleicwngpl 301 dsviqrqegl tdnpsqnqhi dtdgrqeegs lpiieadkpm sslytntrdr emeeniryde 361 dllriedssi adtrgniyta dtsgdtefnd isvmvekaeq esssthevii rckdwkvcsk 421 lyaafeevvl aishdescvf hcsldrgsle dsedvekpre rgqiiyyiar skgl // LOCUS NP_013392 645 aa linear PLN 30-JUN-2025 DEFINITION GTPase GUF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013392 VERSION NP_013392.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182177.1 REFERENCE 1 (residues 1 to 645) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 645) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 645) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 645) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09601. Method: conceptual translation. FEATURES Location/Qualifiers source 1..645 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..645 /product="GTPase GUF1" /calculated_mol_wt="73058" Region 41..644 /region_name="LepA" /note="Translation elongation factor EF-4, membrane-bound GTPase [Translation, ribosomal structure and biogenesis]; COG0481" /db_xref="CDD:440249" CDS 1..645 /gene="GUF1" /locus_tag="YLR289W" /coded_by="NM_001182177.1:1..1938" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16415861]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:18442968]" /experiment="EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:18442968]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:18442968]" /note="Mitochondrial matrix GTPase; associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor" /db_xref="GeneID:850996" /db_xref="SGD:S000004280" ORIGIN 1 mlkfrirpvr hircykrhay flrynhtttp aqklqaqieq iplenyrnfs ivahvdhgks 61 tlsdrlleit hvidpnarnk qvldklever ergitikaqt csmfykdkrt gknyllhlid 121 tpghvdfrge vsrsyascgg aillvdasqg iqaqtvanfy lafslglkli pvinkidlnf 181 tdvkqvkdqi vnnfelpeed iigvsaktgl nveelllpai idrippptgr pdkpfrallv 241 dswydaylga vllvnivdgs vrkndkvica qtkekyevkd igimypdrts tgtlktgqvg 301 ylvlgmkdsk eakigdtimh lskvnetevl pgfeeqkpmv fvgafpadgi efkamdddms 361 rlvlndrsvt leretsnalg qgwrlgflgs lhasvfrerl ekeygsklii tqptvpylve 421 ftdgkkklit npdefpdgat krvnvaafhe pfieavmtlp qeylgsvirl cdsnrgeqid 481 itylntngqv mlkyylplsh lvddffgklk svsrgfasld yedagyrisd vvklqllvng 541 naidalsrvl hksevervgr ewvkkfkeyv ksqlyevviq arannkiiar etikarrkdv 601 lqklhasdvs rrkkllakqk egkkhmktvg niqinqeayq aflrr // LOCUS NP_013393 277 aa linear PLN 30-JUN-2025 DEFINITION ubiquinone biosynthesis protein COQ11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013393 VERSION NP_013393.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182178.1 REFERENCE 1 (residues 1 to 277) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 277) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 277) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 277) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09602. Method: conceptual translation. FEATURES Location/Qualifiers source 1..277 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..277 /product="ubiquinone biosynthesis protein COQ11" /calculated_mol_wt="31393" Region 7..>204 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" Site order(9,11..12,14,33..35,79..81,162..164,175,179,200..203) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:187535" Site order(128,164,175,179) /site_type="active" /db_xref="CDD:187535" CDS 1..277 /gene="COQ11" /locus_tag="YLR290C" /gene_synonym="MRX2" /coded_by="NM_001182178.1:1..834" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961|PMID:17054397]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:25631044]" /note="Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes; required for synthesis of wild-type levels of Coenzyme Q (ubiquinone); member of the short-chain dehydrogenase/reductase (SDR) superfamily; orthologous gene in some other fungi is fused to the COQ10 ortholog" /db_xref="GeneID:850997" /db_xref="SGD:S000004281" ORIGIN 1 mipklivfgg ngflgkricq eavtsgyqvv svsrsgkaph snelndkqwm qevqwtaadi 61 fkpdsyhell nnatnvvhsl gillenenyk qtlsksptyd sksrllsfga gpnplkkssp 121 yftyemmnkq saiiladtfk qkilkkskke qekanqrsft yisadkgfpl ipsgyinskr 181 eaeielekmq ryfrpiivrp gfmfdehrna igprsfihta lellycgnkf llrnklqlln 241 dlirptvstq qvsksvlkni enpdfkgvvt leeilka // LOCUS NP_013394 381 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF2B subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_013394 VERSION NP_013394.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182179.1 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09603. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..381 /product="translation initiation factor eIF2B subunit beta" /calculated_mol_wt="42439" Region 33..358 /region_name="IF-2B" /note="Initiation factor 2 subunit family; pfam01008" /db_xref="CDD:395798" CDS 1..381 /gene="GCD7" /locus_tag="YLR291C" /coded_by="NM_001182179.1:1..1146" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8506384|PMID:8336705]" /experiment="EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:8506384]" /experiment="EXISTENCE:genetic interaction:GO:0003743 translation initiation factor activity [PMID:8336705]" /experiment="EXISTENCE:genetic interaction:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8336705]" /experiment="EXISTENCE:genetic interaction:GO:0006446 regulation of translational initiation [PMID:8164676|PMID:8887689]" /experiment="EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:8887689|PMID:8164676]" /experiment="EXISTENCE:mutant phenotype:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8441423]" /experiment="EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:9032257]" /experiment="EXISTENCE:mutant phenotype:GO:0030234 enzyme regulator activity [PMID:9032257]" /experiment="EXISTENCE:physical interaction:GO:0003743 translation initiation factor activity [PMID:8336705]" /experiment="EXISTENCE:physical interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8336705]" /experiment="EXISTENCE:physical interaction:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8336705|PMID:8506384]" /experiment="EXISTENCE:physical interaction:GO:0006446 regulation of translational initiation [PMID:8887689]" /experiment="EXISTENCE:physical interaction:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:8336705]" /note="Beta subunit of translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as negative regulator of GCN4 expression; mutations in human ortholog EIF2B2 cause fatal brain disease childhood ataxia with central nervous system hypomyelination (CACH); human ortholog can complement yeast mutant, allows growth down-regulation of yeast gene" /db_xref="GeneID:850998" /db_xref="SGD:S000004282" ORIGIN 1 mssqaftsvh pnaatsdvnv tidtfvaklk rrqvqgsyai aletlqllmr fisaarwnhv 61 ndlieqirdl gnslekahpt afscgnvirr ilavlrdeve edtmsttvts tsvaepliss 121 mfnllqkpeq phqnrknssg sssmktktdy rqvaiqgikd lideiknide giqqiaidli 181 hdheilltpt pdsktvlkfl itarersnrt ftvlvtegfp nntknahefa kklaqhniet 241 lvvpdsavfa lmsrvgkvii gtkavfvngg tissnsgvss vcecarefrt pvfavaglyk 301 lsplypfdve kfvefggsqr ilprmdprkr ldtvnqitdy vppenidiyi tnvggfnpsf 361 iyriawdnyk qidvhldknk a // LOCUS NP_013395 193 aa linear PLN 30-JUN-2025 DEFINITION Sec63 complex subunit SEC72 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013395 VERSION NP_013395.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182180.1 REFERENCE 1 (residues 1 to 193) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 193) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 193) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 193) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09604. Method: conceptual translation. FEATURES Location/Qualifiers source 1..193 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..193 /product="Sec63 complex subunit SEC72" /calculated_mol_wt="21476" Region 69..>180 /region_name="Spy" /note="Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; COG3914" /db_xref="CDD:443119" Region 139..169 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..193 /gene="SEC72" /locus_tag="YLR292C" /gene_synonym="SEC67; SIM2" /coded_by="NM_001182180.1:1..582" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9252322]" /experiment="EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7758110]" /experiment="EXISTENCE:genetic interaction:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:32513868]" /experiment="EXISTENCE:mutant phenotype:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:32513868]" /experiment="EXISTENCE:physical interaction:GO:0031207 Sec62/Sec63 complex [PMID:8051213]" /note="Non-essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and translocation into the ER; other members are Sec63p, Sec62p, and Sec66p" /db_xref="GeneID:850999" /db_xref="SGD:S000004283" ORIGIN 1 mvtleynans klitasdavv alstetnidq invlttslig etnpnftpqp nealskmikg 61 lfesgmknlq qkklnealkn vslaiemaqr krapweafai qlpelhfmlr skidlclilg 121 khlealqdld fllgtgliqp dvfvrkadcl lklrqweear atcerglala pedmklrall 181 ietarnlaey nge // LOCUS NP_013396 219 aa linear PLN 30-JUN-2025 DEFINITION Ran GTPase GSP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013396 VERSION NP_013396.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182181.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09605. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..219 /product="Ran GTPase GSP1" /calculated_mol_wt="24679" Region 4..216 /region_name="PTZ00132" /note="GTP-binding nuclear protein Ran; Provisional" /db_xref="CDD:240284" CDS 1..219 /gene="GSP1" /locus_tag="YLR293C" /gene_synonym="CNR1; CST17" /coded_by="NM_001182181.1:1..660" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:9305944|PMID:7816822|PMID:7744835]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11024003|PMID:8455603]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11024003]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0046822 regulation of nucleocytoplasmic transport [PMID:29146254]" /experiment="EXISTENCE:direct assay:GO:1901987 regulation of cell cycle phase transition [PMID:29146254]" /experiment="EXISTENCE:genetic interaction:GO:0006997 nucleus organization [PMID:8455603]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11404326]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:7816822]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:7816822]" /note="Ran GTPase; GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; GSP1 has a paralog, GSP2, that arose from the whole genome duplication" /db_xref="GeneID:851000" /db_xref="SGD:S000004284" ORIGIN 1 msapaangev ptfklvlvgd ggtgkttfvk rhltgefekk yiatigvevh plsfytnfge 61 ikfdvwdtag qekfgglrdg yyinaqcaii mfdvtsrity knvpnwhrdl vrvcenipiv 121 lcgnkvdvke rkvkaktitf hrkknlqyyd isaksnynfe kpflwlarkl agnpqlefva 181 spalappevq vdeqlmqqyq qemeqatalp lpdeddadl // LOCUS NP_013398 124 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit h [Saccharomyces cerevisiae S288C]. ACCESSION NP_013398 VERSION NP_013398.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182183.1 REFERENCE 1 (residues 1 to 124) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 124) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 124) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 124) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09606. Method: conceptual translation. FEATURES Location/Qualifiers source 1..124 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..124 /product="F1F0 ATP synthase subunit h" /calculated_mol_wt="13997" Region 26..90 /region_name="ATP_sub_h" /note="ATP synthase complex subunit h; pfam10775" /db_xref="CDD:431488" CDS 1..124 /gene="ATP14" /locus_tag="YLR295C" /coded_by="NM_001182183.1:1..375" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:8702761]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:18252710]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:18252710]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:8702761]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:8702761]" /note="Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851002" /db_xref="SGD:S000004286" ORIGIN 1 mfpiasrril lnasvlplrl cnrnftttri synviqdlyl relkdtklap stlqdaegnv 61 kpwnppqkpn lpelelqgpe alkayteqnv etahvakese egesepieed wlvlddaeet 121 kesh // LOCUS NP_001335799 108 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR296W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335799 VERSION NP_001335799.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348859.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80319. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..108 /product="uncharacterized protein" /calculated_mol_wt="12049" CDS 1..108 /locus_tag="YLR296W" /coded_by="NM_001348859.1:1..327" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:851003" /db_xref="SGD:S000004287" ORIGIN 1 mgssrvirhq asnyaqsayq chikepllsl fgnekqhssg ttaaaaitfp qkliidqltr 61 krktkkkkir klglhtsvff flrivcmssa asvftgircv fmfrtnak // LOCUS NP_013400 129 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR297W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013400 VERSION NP_013400.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182185.1 REFERENCE 1 (residues 1 to 129) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 129) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 129) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 129) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09607. Method: conceptual translation. FEATURES Location/Qualifiers source 1..129 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..129 /product="uncharacterized protein" /calculated_mol_wt="13816" CDS 1..129 /locus_tag="YLR297W" /coded_by="NM_001182185.1:1..390" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from nucleus to vacuole upon DNA replication stress; YLR297W has a paralog, YOR186W, that arose from the whole genome duplication" /db_xref="GeneID:851004" /db_xref="SGD:S000004288" ORIGIN 1 mvegdfvdeq sniallssks mcgdhhsvkn sigdeifkll tkilnsdeka sgdvhtlvsg 61 tpdlsnfnld neplenilav fiisfiivvv gvlllgligm ifislrsgss ndkklqsnde 121 ekqalaeka // LOCUS NP_013401 231 aa linear PLN 30-JUN-2025 DEFINITION Yhc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013401 VERSION NP_013401.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182186.1 REFERENCE 1 (residues 1 to 231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 231) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09608. Method: conceptual translation. FEATURES Location/Qualifiers source 1..231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..231 /product="Yhc1p" /calculated_mol_wt="26914" Region 1..217 /region_name="COG5136" /note="U1 snRNP-specific protein C [RNA processing and modification]" /db_xref="CDD:227465" CDS 1..231 /gene="YHC1" /locus_tag="YLR298C" /coded_by="NM_001182186.1:1..696" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0030627 pre-mRNA 5'-splice site binding [PMID:12214237]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:direct assay:GO:1905216 positive regulation of RNA binding [PMID:28829039]" /experiment="EXISTENCE:mutant phenotype:GO:0000395 mRNA 5'-splice site recognition [PMID:12214237]" /experiment="EXISTENCE:physical interaction:GO:0000243 commitment complex [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0003729 mRNA binding [PMID:10072386]" /note="Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site" /db_xref="GeneID:851005" /db_xref="SGD:S000004289" ORIGIN 1 mtryyceych sylthdtlsv rkshlvgknh lritadyyrn kardiinkhn hkrrhigkrg 61 rkerenssqn etlkvtclsn kekrhimhvk kmnqkelaqt sidtlkllyd gspgyskvfv 121 danrfdigdl vkasklpqra neksahhsfk qtsrsrdetc esnpfprlnn pkkleppkil 181 sqwsntipkt sifysvdilq ttikeskkrm hsdgirkpss angykrrryg n // LOCUS NP_013402 660 aa linear PLN 30-JUN-2025 DEFINITION gamma-glutamyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013402 VERSION NP_013402.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182187.1 REFERENCE 1 (residues 1 to 660) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 660) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 660) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 660) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 660) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 660) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 660) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 660) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 660) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09609. Method: conceptual translation. FEATURES Location/Qualifiers source 1..660 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..660 /product="gamma-glutamyltransferase" /EC_number="2.3.2.2" /EC_number="3.4.19.13" /calculated_mol_wt="73050" Region 101..652 /region_name="G_glu_transpept" /note="Gamma-glutamyltranspeptidase; cl19223" /db_xref="CDD:450276" CDS 1..660 /gene="ECM38" /locus_tag="YLR299W" /gene_synonym="CIS2" /coded_by="NM_001182187.1:1..1983" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:6143574]" /experiment="EXISTENCE:mutant phenotype:GO:0006751 glutathione catabolic process [PMID:11672438]" /experiment="EXISTENCE:mutant phenotype:GO:0006805 xenobiotic metabolic process [PMID:16857395]" /experiment="EXISTENCE:mutant phenotype:GO:0036374 glutathione hydrolase activity [PMID:11672438]" /note="Gamma-glutamyltranspeptidase; major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation" /db_xref="GeneID:851006" /db_xref="SGD:S000004290" ORIGIN 1 mllcnrkvpk tlntcfilhi ftlltlgvlv sgmpskmvsf asqetlqrin nllrgsanrd 61 vdiiaeylkk dddddggdkd hhnididplp rrpsltpdrq llkvglhgai ssdlevcsnl 121 tinevllkfp gsnaadaavt qalckgmvnf fnsgiggggy vvfsgkdded hlsidfreka 181 pmdshkfmfe ncslcskigg lavgvpgelm glyrlfkerg sgqvdwrdli epvaklgsvg 241 wqigealgat lelyedvflt lkedwsfvln sthdgvlkeg dwikrpalsn mlmelakngs 301 vapfydpdhw iaksmidtva kyngimnlqd vssydvhvtk plsmkirkga nfipdndmtv 361 ltssgsssga allaalrimd nfqnqeggdy ekettyhlle smkwmasars rlgdfegeal 421 pkhieevldp ewalkavksi krnsqdgnfk tlenwtlydp aydinnphgt ahfsivdshg 481 navsltttin llfgslvhdp ktgvifnnem ddfaqfnksn sfelapsiyn fpepgkrpls 541 staptivlse lgipdlvvga sggsrittsv lqtivrtywy nmpiletiay prihhqllpd 601 rielesfpmi gkavlstlke mgytmkevfp ksvvnairnv rgewhavsdy wrkrgissvy // LOCUS NP_013403 448 aa linear PLN 30-JUN-2025 DEFINITION glucan 1,3-beta-glucosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013403 VERSION NP_013403.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182188.1 REFERENCE 1 (residues 1 to 448) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 448) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 448) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 448) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09610. Method: conceptual translation. FEATURES Location/Qualifiers source 1..448 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..448 /product="glucan 1,3-beta-glucosidase" /EC_number="3.2.1.58" /calculated_mol_wt="51180" Region 105..349 /region_name="BglC" /note="Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism]; COG2730" /db_xref="CDD:442036" CDS 1..448 /gene="EXG1" /locus_tag="YLR300W" /gene_synonym="BGL1; SCW6" /coded_by="NM_001182188.1:1..1347" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:19129178]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9748433]" /experiment="EXISTENCE:mutant phenotype:GO:0044042 glucan metabolic process [PMID:7565587]" /note="Major exo-1,3-beta-glucanase of the cell wall; involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes; EXG1 has a paralog, SPR1, that arose from the whole genome duplication" /db_xref="GeneID:851007" /db_xref="SGD:S000004291" ORIGIN 1 mlslktllct lltvssvlat pvpardpssi qfvheenkkr yydydhgslg epirgvnigg 61 wlllepyitp slfeafrtnd dndegipvde yhfcqylgkd laksrlqshw stfyqeqdfa 121 niasqgfnlv ripigywafq tldddpyvsg lqesyldqai gwarnnslkv wvdlhgaags 181 qngfdnsglr dsykfledsn lavttnvlny ilkkysaeey ldtvigieli neplgpvldm 241 dkmkndylap ayeylrnnik sdqviiihda fqpynywddf mtendgywgv tidhhhyqvf 301 asdqlersid ehikvacewg tgvlneshwt vcgefaaalt dctkwlnsvg fgarydgswv 361 ngdqtssyig scannddiay wsderkentr ryveaqldaf emrggwiiwc yktesslewd 421 aqrlmfnglf pqpltdrkyp nqcgtisn // LOCUS NP_013404 244 aa linear PLN 30-JUN-2025 DEFINITION Hri1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013404 VERSION NP_013404.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182189.1 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09611. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..244 /product="Hri1p" /calculated_mol_wt="27370" Region 3..241 /region_name="HRI1" /note="Protein HRI1; pfam16815" /db_xref="CDD:407068" CDS 1..244 /gene="HRI1" /locus_tag="YLR301W" /coded_by="NM_001182189.1:1..735" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:physical interaction:GO:0005789 endoplasmic reticulum membrane [PMID:12518317]" /experiment="EXISTENCE:physical interaction:GO:0006612 protein targeting to membrane [PMID:12518317]" /note="hypothetical protein that interacts with Sec72p and Hrr25p" /db_xref="GeneID:851008" /db_xref="SGD:S000004292" ORIGIN 1 mpallkrllf qvgphpnert ftlssvstdg hyislrpfvk psgdelsfpf ewafagtnet 61 vkandqgngv vtqdfnfwld tnvylnvpnt hrgevnttwk nwdsgcveet gavypfgadk 121 esvsfrelwq pvdpsredlv ivspnnekfs snarsivlkv tdeaydglvi vigrwiqgfl 181 sqknnntieg lnfirllekd sgksefllsy gkevnkipqs yenlkkgstv tsnglnwevi 241 eyha // LOCUS NP_001335800 120 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR302C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335800 VERSION NP_001335800.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348860.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80320. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..120 /product="uncharacterized protein" /calculated_mol_wt="13959" CDS 1..120 /locus_tag="YLR302C" /coded_by="NM_001348860.1:1..363" /note="hypothetical protein; conserved among S. cerevisiae strains" /db_xref="GeneID:851011" /db_xref="SGD:S000004293" ORIGIN 1 mrwhcmdggn rivsmylttl yytkeivdek treqekgkts fltdallnli yilffsssvf 61 nwtrchlfdt svimlhsfhe dgaltnlish lptttvpqyr qlhvpfailr scdlkrkskk // LOCUS NP_013406 444 aa linear PLN 30-JUN-2025 DEFINITION bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013406 VERSION NP_013406.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182191.1 REFERENCE 1 (residues 1 to 444) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 444) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 444) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 444) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09612. Method: conceptual translation. FEATURES Location/Qualifiers source 1..444 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..444 /product="bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17" /EC_number="2.5.1.47" /EC_number="2.5.1.49" /calculated_mol_wt="48541" Region 4..436 /region_name="OAH_OAS_sulfhy" /note="OAH/OAS sulfhydrylase; TIGR01326" /db_xref="CDD:273555" Site order(31..34,36..37,56,58,84..85,87..88,111,116,119,208, 267,278,280..281,371) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:99738" Site order(85..87,111,154,183,206,208..209) /site_type="active" /note="substrate-cofactor binding pocket [active]" /db_xref="CDD:99738" Site order(85..87,111,183,186,206,208..209) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99738" Site 209 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99738" CDS 1..444 /gene="MET17" /locus_tag="YLR303W" /gene_synonym="MET15; MET25" /coded_by="NM_001182191.1:1..1335" /experiment="EXISTENCE:direct assay:GO:0004124 cysteine synthase activity [PMID:7765825]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0051009 O-acetylhomoserine sulfhydrylase activity [PMID:7765825|PMID:36379252]" /experiment="EXISTENCE:mutant phenotype:GO:0006555 methionine metabolic process [PMID:1101032]" /note="O-acetyl homoserine-O-acetyl serine sulfhydrylase; involved in methionine and cysteine biosynthesis; long considered essential for inorganic sulfur assimilation, but inefficient homocysteine synthase Hsu1p enables met17 null cells to assimilate enough inorganic sulfur for survival and proliferation; growth failure of met17 null can be explained by toxic accumulation of H2S gas due to a metabolic bottleneck" /db_xref="GeneID:851010" /db_xref="SGD:S000004294" ORIGIN 1 mpshfdtvql hagqenpgdn ahrsravpiy attsyvfens khgsqlfgle vpgyvysrfq 61 nptsnvleer iaaleggaaa lavssgqaaq tlaiqglaht gdnivstsyl yggtynqfki 121 sfkrfgiear fvegdnpeef ekvfdertka vyletignpk ynvpdfekiv aiahkhgipv 181 vvdntfgagg yfcqpikyga divthsatkw igghgttigg iivdsgkfpw kdypekfpqf 241 sqpaegyhgt iyneaygnla yivhvrtell rdlgplmnpf asflllqgve tlslraerhg 301 enalklakwl eqspyvswvs ypglashshh enakkylsng fggvlsfgvk dlpnadketd 361 pfklsgaqvv dnlklasnla nvgdaktlvi apyftthkql ndkeklasgv tkdlirvsvg 421 iefiddiiad fqqsfetvfa gqkp // LOCUS NP_013407 778 aa linear PLN 30-JUN-2025 DEFINITION aconitate hydratase ACO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013407 VERSION NP_013407.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182192.1 REFERENCE 1 (residues 1 to 778) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 778) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 778) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 778) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 778) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 778) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 778) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 778) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 778) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09613. Method: conceptual translation. FEATURES Location/Qualifiers source 1..778 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..778 /product="aconitate hydratase ACO1" /EC_number="4.2.1.3" /calculated_mol_wt="85237" Region 41..772 /region_name="aconitase_mito" /note="aconitate hydratase, mitochondrial; TIGR01340" /db_xref="CDD:273561" CDS 1..778 /gene="ACO1" /locus_tag="YLR304C" /gene_synonym="GLU1" /coded_by="NM_001182192.1:1..2337" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:17698960]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:17698960]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:18959479]" /experiment="EXISTENCE:direct assay:GO:0003994 aconitate hydratase activity [PMID:1972545]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:15692048]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15975908]" /experiment="EXISTENCE:direct assay:GO:0006099 tricarboxylic acid cycle [PMID:1972545]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10869431]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:15692048]" /experiment="EXISTENCE:mutant phenotype:GO:0003994 aconitate hydratase activity [PMID:1972545]" /note="Aconitase; required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy; mutation in human homolog ACO2 is associated with dominant optic nerve atrophy; human homolog ACO2 can complement yeast null mutant" /db_xref="GeneID:851013" /db_xref="SGD:S000004295" ORIGIN 1 mlsarsaikr pivrglatvs nltrdskvnq nlledhsfin ykqnvetldi vrkrlnrpft 61 yaekilyghl ddphgqdiqr gvsylklrpd rvacqdataq mailqfmsag lpqvakpvtv 121 hcdhliqaqv ggekdlkrai dlnkevydfl asatakynmg fwkpgsgiih qivlenyafp 181 galiigtdsh tpnagglgql aigvggadav dvmagrpwel kapkilgvkl tgkmngwtsp 241 kdiilklagi ttvkggtgki veyfgdgvdt fsatgmgtic nmgaeigatt svfpfnksmi 301 eyleatgrgk iadfaklyhk dllsadkdae ydevveidln tlepyingpf tpdlatpvsk 361 mkevavannw pldvrvglig sctnssyedm srsasivkda aahglkskti ftvtpgseqi 421 ratierdgql etfkefggiv lanacgpcig qwdrrdikkg dkntivssyn rnftsrndgn 481 pqthafvasp elvtafaiag dlrfnpltdk lkdkdgnefm lkpphgdglp qrgydagent 541 yqappadrst vevkvsptsd rlqllkpfkp wdgkdakdmp ilikavgktt tdhismagpw 601 lkyrghleni snnymigain aenkkancvk nvytgeykgv pdtardyrdq gikwvvigde 661 nfgegssreh aaleprflgg faiitksfar ihetnlkkqg llplnfknpa dydkinpddr 721 idilglaela pgkpvtmrvh pkngkpwdav lthtfndeqi ewfkygsaln kikadekk // LOCUS NP_013408 1900 aa linear PLN 30-JUN-2025 DEFINITION 1-phosphatidylinositol 4-kinase STT4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013408 VERSION NP_013408.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182193.1 REFERENCE 1 (residues 1 to 1900) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1900) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1900) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1900) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1900) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09614. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1900 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1900 /product="1-phosphatidylinositol 4-kinase STT4" /EC_number="2.7.1.67" /calculated_mol_wt="214477" Region 1..1900 /region_name="TEL1" /note="Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032" /db_xref="CDD:227365" CDS 1..1900 /gene="STT4" /locus_tag="YLR305C" /coded_by="NM_001182193.1:1..5703" /experiment="EXISTENCE:direct assay:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:9346907]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19075114|PMID:12015967]" /experiment="EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:9346907]" /experiment="EXISTENCE:genetic interaction:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:10930462]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:22977244]" /experiment="EXISTENCE:mutant phenotype:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:8288577]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:32726584]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:22977244]" /experiment="EXISTENCE:mutant phenotype:GO:0061909 autophagosome-lysosome fusion [PMID:31125705]" /experiment="EXISTENCE:mutant phenotype:GO:0140504 microlipophagy [PMID:32726584]" /note="Phosphatidylinositol-4-kinase; functions in Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization; required for autophagosome-vacuole fusion during autophagy and for lipophagy in stationary phase cells and during nitrogen starvation; localizes to plasma membrane and mitochondria in HTP studies" /db_xref="GeneID:851014" /db_xref="SGD:S000004296" ORIGIN 1 mrftrglkas sslrakaigr ltklstgapn dqnsngttld lithtlpify stntskiyti 61 pltlsewevl tslcvaiptt ldlvetmlke iiapyfletp rqrisdvlss kfkleqmrnp 121 ielltfqltk fmiqaceqyp vlyeniggii styfervlki ftikqsglls lvgfinafiq 181 fpnsteltkf twkklaklvl rgsflnevdk ilnssatftn dsivqyydag nelssaylle 241 lisrlqvsli shllntshvg anlsefllnq qyqfykfdqe vadenddtkc iddfffnvrs 301 nkqfftdmck islqfcsesh ildlstdnra rfsfdtrahy lqtlclipfi edteselfes 361 ftnvvsesid kfflsdvvtp slikaivasa sllnfftekl sltlirmfpl lvasphitte 421 tvndvakift tglyplneda ivstiysmnn llavsedgsp vpvlrerqlt itsgkniekd 481 yfplrnssas ldgtgallgn ttvgqlsshd vnsgatmtyh aslisncvaa tttiasyynt 541 qsitaltisi ltqkvnsmsk eldgvilnsl arlapntslt efslllkffk srtviatkid 601 dsallkniik akcviskell arhfssdlyf mylhdlldsi iasgeverle hhrpqteisr 661 vadqiatyle plaallpvpg dtpldinkde vttnkfrnaw fnfvihgyhl ggpivkrnfs 721 flltiaynsp plasefpann kelslemnti lrrgssneni kqqkqqitey fntnivqyrt 781 tssskimfla aavlletirc eagdcsktll yfsdpsilsg siekciavls vsmirkyarl 841 iqkgndaifn skmiaqqlnn lllclshrep tlqdaafhac eifirsipss lchhlslytl 901 ldmltalfds ildseahkfe pryefklkhs kttilvpsss swrattlsrl hksakewvri 961 llnrsnqdtk illqsyisdl geysrlnsve fgvsfamdma glilpadkel srltyygpek 1021 pntisgfisl hswrskylfd taitsspedi krqigistqn irknltlgnk iitkdvtdfl 1081 dmatallilg ngapasliyd ivhipfevft saslkiatnv wltiitekpe vahlllvevc 1141 ycwmrsiddn iglysrdhdl kgeeyqkmey spydkaginr daknasqamq phlhvikffa 1201 shfegtlfqs dfllkiftkc alygiknlyk aslhpfarmi rhelllfatl vlnasykqgs 1261 kymgrlsqei tngalswfkr pvawpfgsne lkikadlsvt rdlflqlnkl sslmsrhcgk 1321 dykilnyfla seiqqiqtwl tptekiegad sneltsdive atfakdptla inllqrcysk 1381 kaedvlvglv akhalmcvgs psaldlfikg shlsskkdlh atlywapvsp lksinlflpe 1441 wqgnsfilqf siyslesqdv nlaffyvpqi vqclrydktg yverlildta kisvlfshqi 1501 iwnmlancyk ddegiqedei kptldrirer mvssfsqshr dfyerefeff devtgisgkl 1561 kpyikkskae kkhkideems kievkpdvyl psnpdgvvid idrksgkplq shakapfmat 1621 fkikkdvkdp ltgknkevek wqaaifkvgd dcrqdvlalq lislfrtiws sigldvyvfp 1681 yrvtatapgc gvidvlpnsv srdmlgreav nglyeyftsk fgnestiefq narnnfvksl 1741 agysvisyll qfkdrhngni myddqghclh idfgfifdiv pggikfeavp fkltkemvkv 1801 mggspqtpay ldfeelcika ylaarphvea iiecvnpmlg sglpcfkghk tirnlrarfq 1861 pqktdheaal ymkalirksy esiftkgyde fqrltngipy // LOCUS NP_013409 188 aa linear PLN 30-JUN-2025 DEFINITION NEDD8-conjugating protein UBC12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013409 VERSION NP_013409.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182194.1 REFERENCE 1 (residues 1 to 188) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 188) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 188) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 188) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09615. Method: conceptual translation. FEATURES Location/Qualifiers source 1..188 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..188 /product="NEDD8-conjugating protein UBC12" /EC_number="2.3.2.34" /calculated_mol_wt="21072" Region 27..169 /region_name="UBCc_UBE2F_UBE2M" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin conjugating enzymes E2 F, E2 M and related proteins; cd23794" /db_xref="CDD:467414" CDS 1..188 /gene="UBC12" /locus_tag="YLR306W" /coded_by="NM_001182194.1:1..567" /experiment="EXISTENCE:direct assay:GO:0019788 NEDD8 transferase activity [PMID:9545234]" /experiment="EXISTENCE:direct assay:GO:0045116 protein neddylation [PMID:9545234]" /experiment="EXISTENCE:mutant phenotype:GO:0019788 NEDD8 transferase activity [PMID:9545234]" /experiment="EXISTENCE:mutant phenotype:GO:0045116 protein neddylation [PMID:9545234]" /note="Enzyme that mediates the conjugation of Rub1p; a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes" /db_xref="GeneID:851015" /db_xref="SGD:S000004297" ORIGIN 1 mlklrqlqkk kqkenensss iqpnlsaari rlkrdldsld lpptvtlnvi tspdsadrsq 61 spklevivrp degyynygsi nfnldfnevy pieppkvvcl kkifhpnidl kgnvclnilr 121 edwspaldlq siitgllflf lepnpndpln kdaakllceg ekefaeavrl tmsggsiehv 181 kydnivsp // LOCUS NP_013410 301 aa linear PLN 30-JUN-2025 DEFINITION chitin deacetylase CDA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013410 VERSION NP_013410.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182195.1 REFERENCE 1 (residues 1 to 301) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 301) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 301) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 301) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09616. Method: conceptual translation. FEATURES Location/Qualifiers source 1..301 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..301 /product="chitin deacetylase CDA1" /EC_number="3.5.1.41" /calculated_mol_wt="34511" Region 108..281 /region_name="CE4_MrCDA_like" /note="Catalytic NodB homology domain of Mucor rouxii chitin deacetylase and similar proteins; cd10952" /db_xref="CDD:200576" Site order(113..116,162..167,200,202..203,224,230..231,261,263) /site_type="other" /note="NodB motif" /db_xref="CDD:200576" Site order(115..116,162,166,202..204,263) /site_type="active" /note="putative active site [active]" /db_xref="CDD:200576" CDS 1..301 /gene="CDA1" /locus_tag="YLR307W" /coded_by="NM_001182195.1:1..906" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:genetic interaction:GO:0004099 chitin deacetylase activity [PMID:8940152]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:10544249|PMID:8940152]" /experiment="EXISTENCE:mutant phenotype:GO:0004099 chitin deacetylase activity [PMID:9133736|PMID:8940152]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:10544249]" /note="Chitin deacetylase; together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall" /db_xref="GeneID:851016" /db_xref="SGD:S000004298" ORIGIN 1 mkifntiqsv lfaafflkqg nclasngsta lmgevdmqtp fpewlteftn ltqwpgidpp 61 yipldyinlt evpeldryyp gqcpkisreq csfdcyncid vddvtscfkl sqtfddgpap 121 ateallkklr qrttffvlgi ntvnypdiye hilerghlig thtwsheflp slsneeivaq 181 iewsiwamna tgkhfpkyfr ppygaidnrv raivkqfglt vvlwdldtfd wklitnddfr 241 teeeilmdin twkgkrkgli lehdgarrtv evaikineli gsdqltiaec igdtdyiery 301 d // LOCUS NP_878131 87 aa linear PLN 30-JUN-2025 DEFINITION Dpa10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878131 VERSION NP_878131.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184535.1 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09617. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..87 /product="Dpa10p" /calculated_mol_wt="9502" CDS 1..87 /gene="DPA10" /locus_tag="YLR307C-A" /coded_by="NM_001184535.1:1..264" /note="Putative mitochondrial hypothetical protein" /db_xref="GeneID:1466419" /db_xref="SGD:S000028525" ORIGIN 1 mslrnismit knlqttakcy vpkssptstt ipvirdastt qcrrittvin itslkgysps 61 prtvhdkpiv ictdneevet vsehvkv // LOCUS NP_013411 312 aa linear PLN 30-JUN-2025 DEFINITION chitin deacetylase CDA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013411 VERSION NP_013411.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182196.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09618. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..312 /product="chitin deacetylase CDA2" /EC_number="3.5.1.41" /calculated_mol_wt="35562" Region 119..291 /region_name="CE4_SF" /note="Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; cl15692" /db_xref="CDD:472828" CDS 1..312 /gene="CDA2" /locus_tag="YLR308W" /coded_by="NM_001182196.1:1..939" /experiment="EXISTENCE:genetic interaction:GO:0004099 chitin deacetylase activity [PMID:8940152]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:10544249|PMID:8940152]" /experiment="EXISTENCE:mutant phenotype:GO:0004099 chitin deacetylase activity [PMID:9133736|PMID:8940152]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:10544249]" /note="Chitin deacetylase; together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall" /db_xref="GeneID:851017" /db_xref="SGD:S000004299" ORIGIN 1 mriqlntidl qciialsclg qfvhaeanre dlkqidfqfp vleraatktp fpdwlsaftg 61 lkewpgldpp yipldfidfs qipdykeydq nhcdsvprds csfdchhcte hddvytcskl 121 sqtfddgpsa sttklldrlk hnstffnlgv nivqhpdiyq rmqkeghlig shtwshvylp 181 nvsnekiiaq iewsiwamna tgnhtpkwfr ppyggidnrv raitrqfglq avlwdhdtfd 241 wslllndsvi teqeilqnvi nwnksgtgli lehdstektv dlaikinkli gddqstvshc 301 vggidyikef ls // LOCUS NP_013412 911 aa linear PLN 30-JUN-2025 DEFINITION Imh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013412 VERSION NP_013412.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182197.2 REFERENCE 1 (residues 1 to 911) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 911) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 911) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 911) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 911) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 911) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 911) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 911) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 911) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09619. Method: conceptual translation. FEATURES Location/Qualifiers source 1..911 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..911 /product="Imh1p" /calculated_mol_wt="105094" Region 42..>734 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 865..906 /region_name="GRIP" /note="GRIP domain; pfam01465" /db_xref="CDD:460221" CDS 1..911 /gene="IMH1" /locus_tag="YLR309C" /gene_synonym="SYS3" /coded_by="NM_001182197.2:1..2736" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15077113]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9880327]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:9880327]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:26966233]" /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:16926193]" /note="Protein involved in vesicular transport; mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi" /db_xref="GeneID:851018" /db_xref="SGD:S000004300" ORIGIN 1 mfkqlsqigk nltdelakgl addmsptpse qqieddksgl pkeiqaklrk fekyeqkypl 61 llsayknekl ksekleavek ilaentpisn iddavdtlpa ffqdlnnknn llndeikrlt 121 kqnseipesa ssetlkdkee eflkkeqnyk ndiddlkkkm ealnieldtv qkekndtvsg 181 lrekivalen ilkeereakk qkeevsisel keelaiknhs ledsrmkite leqnlsskst 241 imeekssela elnitlkeke rklselekkm kelpkaishq nvgnnnrrkk nrnkgkknkg 301 gittgdisee etvdnsinte eydklkenlq elqekykdce dwkqkyedie aelkdakele 361 nsqleksake letlntelid tkkslkekns eleevrdmlr tvgnelvdak deikessskq 421 neevktvkle lddlrhknat mieayeaknt elrskiells kkvehlknlc tekekeqtts 481 qnkvaklnee isqltyeksn itkeltslrt sykqkektvs yleeqvkqfs eqkdvaekst 541 eqlrkdhaki snrldllkke netlhndiak nsnsyeeylk engklserln ilqekyntlq 601 nvksnsnehi dsikrqceel nvklkestkk ilsledelne yanivqdktr eantlrrlvs 661 dsqtddsskq kelenklayl tdeknkleae ldlqtsrkat elqewkhtvt elkseihalk 721 lreeglksev dalkhvnndi krktqatsdd sdqleqitsn lklslskade knfelqsane 781 kllnlnneln kkfdrllkny rslssqlnal kerqysdksg rvsrsgsigt lananidssp 841 annsnptkle kirsssslel dseknekiay iknvllgfle hkeqrnqllp vismllqlds 901 tdekrlvmsl k // LOCUS NP_013413 1589 aa linear PLN 30-JUN-2025 DEFINITION Ras family guanine nucleotide exchange factor CDC25 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013413 VERSION NP_013413.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182198.1 REFERENCE 1 (residues 1 to 1589) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1589) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1589) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1589) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09620. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1589 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1589 /product="Ras family guanine nucleotide exchange factor CDC25" /calculated_mol_wt="178962" Region 62..122 /region_name="SH3_Sdc25" /note="Src Homology 3 domain of Sdc25/Cdc25 guanine nucleotide exchange factors; cd11883" /db_xref="CDD:212816" Site order(67,69,77,81,99..100,119,121..122) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212816" Region 1117..1246 /region_name="RasGEFN" /note="Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; smart00229" /db_xref="CDD:214571" Site order(1136,1190,1194..1195,1198,1201..1202,1234..1235,1238, 1245) /site_type="other" /note="GTPase interaction site [polypeptide binding]" /db_xref="CDD:100121" Region 1301..1543 /region_name="RasGEF" /note="Guanine nucleotide exchange factor for Ras-like small GTPases; smart00147" /db_xref="CDD:214539" Site order(1334..1336,1347..1348,1350..1352,1354..1355, 1358..1359,1362,1395,1398..1399,1401..1403,1405..1408, 1410..1411,1431,1434,1439..1441,1444,1458..1460,1463..1465, 1467..1469,1471..1474,1491,1495,1530,1533..1534) /site_type="other" /note="Ras interaction site [polypeptide binding]" /db_xref="CDD:238087" CDS 1..1589 /gene="CDC25" /locus_tag="YLR310C" /gene_synonym="CTN1" /coded_by="NM_001182198.1:1..4770" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:1569942|PMID:9047390|PMID:21073870|PMID:8206969]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18930081]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:1334534]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:22575457]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18930081]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8893498]" /experiment="EXISTENCE:direct assay:GO:0007265 Ras protein signal transduction [PMID:9047390]" /experiment="EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9047390|PMID:8206969]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:3021894]" /experiment="EXISTENCE:mutant phenotype:GO:0007265 Ras protein signal transduction [PMID:9047390|PMID:1849965]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:3021894]" /note="Membrane bound guanine nucleotide exchange factor; also known as a GEF or GDP-release factor; indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1; thermosensitivity of the cdc25-5 mutant is functionally complemented by human RASGRF1 or by a fragment of human SOS1 comprising the CDC25-related catalytic domain" /db_xref="GeneID:851019" /db_xref="SGD:S000004301" ORIGIN 1 msdtntsipn tssareagna sqtpsissss ntstttntes ssaslsssps tseltsirpi 61 givvaaydfn ypikkdsssq llsvqqgeti yilnknssgw wdglviddsn gkvnrgwfpq 121 nfgrplrdsh lrkhshpmkk yssskssrrs slnslgnsay lhvprnpsks rrgsstlsas 181 lsnahnaets sghnntvsmn nspfsapnda shitpqssnf nsnaslsqdm tksadgssem 241 ntnaimnnne tnlqtsgeka gpplvaeeti kilpleeiem iingirsnia stwspiplit 301 ktsdyklvyy nkdldiycse lplisnsime sddicdsepk fppndhlvnl ytrdlrknan 361 iedsstrskq seseqnrssl lmekqdsket dgnnnsindd dnnnennkne fneagpssln 421 slsapdltqn iqsrvvapsr ssilaksdif yhysrdiklw telqdltvyy tktahkmflk 481 enrlnftkyf dlisdsivft qlgcrlmqhe ikakscskei kkifkgliss lsrisinshl 541 yfdsafhrkk mdtmndkdnd nqenncsrte gddgkievds vhdlvsvpls gkrnvststt 601 dtltpmrssf stvnendmen fsvlgprnsv nsvvtprtsi qnstledfsp snknfksaks 661 iyemvdvefs kflrhvqlly fvlqssvfsd dntlpqllpr ffkgsfsggs wtnpfstfit 721 defgnatknk avtsnevtas ssknssisri ppkmadaias asgysanset nsqidlkass 781 aasgsvftpf nrpshnrtfs rarvskrkkk ypltvdtlnt mkkkssqife klnnatgehl 841 kiiskpksri rnleinssty eqinqnvlll eilenldlsi finlknlikt psilldlese 901 eflvhamssv ssvlteffdi kqafhdivir limttqqttl ddpylfssmr snfpvghhep 961 fknisntplv kgpfhkkneq lalslfhvlv sqdvefnnle flnnsddfkd acekyveisn 1021 laciivdqli eerenllnya armmknnlta ellkgeqekw fdiysedysd ddsendeaii 1081 ddelgsedyi erkaaniekn lpwfltsdye tslvydsrgk irggtkeali ehltshelvd 1141 aafnvtmlit frsilttref fyaliyrynl yppeglsydd yniwiekksn pikcrvvnim 1201 rtfltqywtr nyyepgipli lnfakmvvse kipgaedllq kineklinen ekepvdpkqq 1261 dsvsavvqtt krdnkspihm sssslpssas saffrlkklk lldidpytya tqltvlehdl 1321 ylritmfecl drawgtkycn mggspnitkf ianantltnf vshtivkqad vktrskltqy 1381 fvtvaqhcke lnnfssmtai vsalysspiy rlkktwdlvs teskdllknl nnlmdskrnf 1441 vkyrellrsv tdvacvpffg vylsdltftf vgnpdflhns tniinfskrt kianiveeii 1501 sfkrfhyklk rlddiqtvie aslenvphie kqyqlslqve prsgntkgst hassasgtkt 1561 akflseftdd kngnflklgk kkppsrlfr // LOCUS NP_013415 398 aa linear PLN 30-JUN-2025 DEFINITION Atg39p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013415 VERSION NP_013415.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182200.1 REFERENCE 1 (residues 1 to 398) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 398) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 398) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 398) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09621. Method: conceptual translation. FEATURES Location/Qualifiers source 1..398 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..398 /product="Atg39p" /calculated_mol_wt="46497" CDS 1..398 /gene="ATG39" /locus_tag="YLR312C" /coded_by="NM_001182200.1:1..1197" /experiment="EXISTENCE:direct assay:GO:0005640 nuclear outer membrane [PMID:35061008]" /experiment="EXISTENCE:direct assay:GO:0097038 perinuclear endoplasmic reticulum [PMID:26040717]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:26040717]" /experiment="EXISTENCE:genetic interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:26040717]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:26040717]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:26040717]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:26040717]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:26040717]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26040717]" /note="Transmembrane receptor with a role in nucleophagy; involved in selective autophagy of the endoplasmic reticulum and nucleus in response to nitrogen starvation or rapamycin treatment; role in nuclear envelope deformation to generate nucleus-derived double-membrane vesicles (NDVs), interacting with Atg8p to target these NDVs to forming autophagosomal membranes; anchored in the outer nuclear membrane, associating with the inner nuclear membrane via amphipathic helices" /db_xref="GeneID:851021" /db_xref="SGD:S000004303" ORIGIN 1 mseeddhwnl vrlrrlrkgr egeeqsskse isldslhess fageddedfd advlsntsse 61 esaqmnriyd frtsnefsna gvnidqtgvp tisesfdtls gsnvggtvlp smegsklkds 121 tirnsstlsd hiidksegks aklkmwhvim lssllsmtfs ylaleysltg dvlagfksqq 181 slrnnerkll ygnidfvdkk sydsssdsls qwapsgkyyv dfdnhiaypl kdddlmgwrr 241 yktdlvilwy ttkarmkdgw hkrinkingg riklhlflkn sfksaqeslr vlhkeqkrrw 301 krlfvllhnk yrqfsphikr yfdhscqkak qcwsgsrlql rklrfksmkp frvfqfkvrk 361 dtnwfvkqlk rfglklqhsr mykamsecrk knyfkckh // LOCUS NP_013416 253 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL57 MRPL15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013416 VERSION NP_013416.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182201.1 REFERENCE 1 (residues 1 to 253) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 253) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 253) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 253) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09622. On Oct 10, 2006 this sequence version replaced NP_013416.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..253 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..253 /product="mitochondrial 54S ribosomal protein mL57 MRPL15" /calculated_mol_wt="28036" Region 85..221 /region_name="RIBOc" /note="Ribonuclease III family; smart00535" /db_xref="CDD:197778" Site order(105..106,109..110,113,116..117,120..121,123..125,138, 204,213) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:238333" Site order(105,108,112,194,197) /site_type="active" /db_xref="CDD:238333" Site order(108,194,197) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:238333" CDS 1..253 /gene="MRPL15" /locus_tag="YLR312W-A" /gene_synonym="mL57" /coded_by="NM_001182201.1:1..762" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:851022" /db_xref="SGD:S000004304" ORIGIN 1 mensmmfisr slrrpvtaln cnlqsvrtvi ylhkgpring lrrdpesylr npsgvlftev 61 nakecqdkvr silqlpkygi nlsnelilqc lthksfahgs kpyneklnll gaqflklqtc 121 ihslkngspa escengqlsl qfsnlgtkfa keltskntac tfvklhnldp fifwkmrdpi 181 kdghingett ifasvlnafi gailstngse kaakfiqgsl ldkedlhslv nianenvasa 241 kakisdkenk afl // LOCUS NP_013417 530 aa linear PLN 30-JUN-2025 DEFINITION Sph1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013417 VERSION NP_013417.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182202.2 REFERENCE 1 (residues 1 to 530) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 530) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 530) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 530) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 530) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09623. On Apr 26, 2011 this sequence version replaced NP_013417.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..530 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..530 /product="Sph1p" /calculated_mol_wt="58875" Region 45..73 /region_name="GIT" /note="Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins; smart00555" /db_xref="CDD:128828" Region 89..119 /region_name="GIT" /note="Helical motif in the GIT family of ADP-ribosylation factor GTPase-activating proteins; smart00555" /db_xref="CDD:128828" CDS 1..530 /gene="SPH1" /locus_tag="YLR313C" /gene_synonym="YLR312C-B" /coded_by="NM_001182202.2:1..1593" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9214378|PMID:9443897]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15282802|PMID:9214378|PMID:9443897]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9443897|PMID:9214378|PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005937 mating projection [PMID:9214378|PMID:11923536]" /experiment="EXISTENCE:genetic interaction:GO:0036267 invasive filamentous growth [PMID:9443897]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:9214378]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9443897]" /note="Protein involved in shmoo formation and bipolar bud site selection; localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p; SPH1 has a paralog, SPA2, that arose from the whole genome duplication" /db_xref="GeneID:851023" /db_xref="SGD:S000004305" ORIGIN 1 misseltndq iidlisdykn fkriieasvp eddrrrnqnr qnrnkdltkl snvqfwqltt 61 dvndelmkrl tdsgadasln dldlkrgkaq sklsrlkdak fhklildift eierrnlhhl 121 dmgthnngld egdlnfylnd tlfesfkind dfmsvngiis ievfrelktq ftlyfqntlh 181 ridpvdtttt rlpilletii kiakligdll pvlssvslqs sleneivylk salshaitst 241 ryfltygdli privaqssis evifafcnia qivkikstsr ddisrnegel sdieagmkpl 301 kiiekvknek ngkdisslgd sgstavsfps sgkpitkksd mpvvvaspsi siieksessi 361 resgkvrnnt sgetnlasvs plkntknssr itsepspreg lplkvvsnsr spspqgntlp 421 ligkfrqdyq asppkkvitk pvaetakpya nippaadvly sptvtkmrkf rekvqkfapn 481 sglglrists eenlnnsdvn stthnaninn lvefvesksm vvlpmagraf // LOCUS NP_013418 520 aa linear PLN 30-JUN-2025 DEFINITION septin CDC3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013418 VERSION NP_013418.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182203.2 REFERENCE 1 (residues 1 to 520) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 520) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 520) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 520) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 520) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09624. On Apr 26, 2011 this sequence version replaced NP_013418.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..520 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..520 /product="septin CDC3" /calculated_mol_wt="59923" Region 97..503 /region_name="CDC3" /note="Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]; COG5019" /db_xref="CDD:227352" CDS 1..520 /gene="CDC3" /locus_tag="YLR314C" /coded_by="NM_001182203.2:1..1563" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:1993729]" /experiment="EXISTENCE:direct assay:GO:0000281 mitotic cytokinesis [PMID:12636916]" /experiment="EXISTENCE:direct assay:GO:0001400 mating projection base [PMID:8791410]" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:18550837|PMID:29321251|PMID:22144691]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:14597621]" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:8636217]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18826657]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010314 phosphatidylinositol-5-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:direct assay:GO:0031105 septin complex [PMID:18550837]" /experiment="EXISTENCE:direct assay:GO:0032160 septin filament array [PMID:15282341]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:12665577]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:4950437]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:15282341]" /experiment="EXISTENCE:mutant phenotype:GO:0031107 septin ring disassembly [PMID:12429908]" /experiment="EXISTENCE:physical interaction:GO:0031105 septin complex [PMID:9813094]" /note="Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud neck act as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells" /db_xref="GeneID:851024" /db_xref="SGD:S000004306" ORIGIN 1 mslkeeqvsi kqdpeqeerq hdqfndvqik qesqdhdgvd sqytngtqnd dserfeaaes 61 dvkvepglgm gitssqsekg qvlpdqpeik firrqingyv gfanlpkqwh rrsikngfsf 121 nllcvgpdgi gkttlmktlf nnddieanlv kdyeeeland qeeeegqgeg henqsqeqrh 181 kvkiksyesv ieengvklnl nvidtegfgd flnndqkswd piikeidsrf dqyldaenki 241 nrhsindkri haclyfiept ghylkpldlk fmqsvyekcn lipviaksdi ltdeeilsfk 301 ktimnqliqs nielfkppiy snddaenshl serlfsslpy avigsndive nysgnqvrgr 361 sypwgvievd ndnhsdfnll knllikqfme elkertskil yenyrsskla klgikqdnsv 421 fkefdpiskq qeektlheak lakleiemkt vfqqkvseke kklqksetel farhkemkek 481 ltkqlkaled kkkqlelsin saspnvnhsp vptkkkgflr // LOCUS NP_013419 153 aa linear PLN 30-JUN-2025 DEFINITION Nkp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013419 VERSION NP_013419.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182204.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09625. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..153 /product="Nkp2p" /calculated_mol_wt="17731" Region 3..66 /region_name="Cnl2_NKP2" /note="Cnl2/NKP2 family protein; pfam09447" /db_xref="CDD:430618" CDS 1..153 /gene="NKP2" /locus_tag="YLR315W" /coded_by="NM_001182204.1:1..462" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:12408861]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:24385296]" /note="Central kinetochore protein and subunit of the Ctf19 complex; mutants have elevated rates of chromosome loss; orthologous to fission yeast kinetochore protein cnl2" /db_xref="GeneID:851025" /db_xref="SGD:S000004307" ORIGIN 1 mnseqllhny vsdsllttli sfqefkqqlq sytsdeqqlq hwyellqard arvtselear 61 ikqffitlrs rllrfleseq lshslsletl idalykindl lqqrlqildd aiqektsela 121 efenmvrsps agdnaipgll qiiqsyinll een // LOCUS NP_013420 322 aa linear PLN 30-JUN-2025 DEFINITION Tad3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013420 VERSION NP_013420.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182205.1 REFERENCE 1 (residues 1 to 322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 322) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09626. On Aug 9, 2000 this sequence version replaced NP_013420.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..322 /product="Tad3p" /calculated_mol_wt="36976" Region 169..279 /region_name="nucleoside_deaminase" /note="Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; cd01285" /db_xref="CDD:238612" Site order(186,207,216..218,254,257) /site_type="active" /note="nucleoside/Zn binding site [active]" /db_xref="CDD:238612" Site order(214,219,223,255..256,259..260,263..264) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238612" Site order(216..218,253..254,257) /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:238612" CDS 1..322 /gene="TAD3" /locus_tag="YLR316C" /coded_by="NM_001182205.1:1..969" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:10550050]" /experiment="EXISTENCE:direct assay:GO:0008251 tRNA-specific adenosine deaminase activity [PMID:10550050]" /note="Subunit of tRNA-specific adenosine-34 deaminase; forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs; localizes to cytosol, nucleus and peroxisomes" /db_xref="GeneID:851027" /db_xref="SGD:S000004308" ORIGIN 1 mvkkvnnplk idyqngiien rllqirnfkd vntpklinvw siridprdsk kvielirndf 61 qkndpvslrh lkrirkdiet stlevvlcsk eyicdegein nklksiwvgt kkyelsddie 121 vpefapstke lnnawsvkyw pliwngnpnd qilndykidm qevrnelsra stlsvkmata 181 gkqfpmvsvf vdpsrkkdkv vaedgrncen slpidhsvmv giravgerlr egvdedansy 241 lcldydvylt hepcsmcsma lihsrvrrvv fltemqrtgs lkltsgdgyc mndnkqlnst 301 yeafqwigee ypvgqvdrdv cc // LOCUS NP_013422 884 aa linear PLN 30-JUN-2025 DEFINITION telomerase reverse transcriptase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013422 VERSION NP_013422.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182207.2 REFERENCE 1 (residues 1 to 884) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 884) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 884) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 884) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 884) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09627. On Apr 26, 2011 this sequence version replaced NP_013422.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..884 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..884 /product="telomerase reverse transcriptase" /EC_number="2.7.7.49" /calculated_mol_wt="102505" Region 282..413 /region_name="Telomerase_RBD" /note="Telomerase ribonucleoprotein complex - RNA binding domain; smart00975" /db_xref="CDD:214948" Region 623..725 /region_name="TERT" /note="Telomerase reverse transcriptase (TERT). Telomerase is a ribonucleoprotein (RNP) that synthesizes telomeric DNA repeats. The telomerase RNA subunit provides the template for synthesis of these repeats. The catalytic subunit of RNP is known as telomerase...; cd01648" /db_xref="CDD:238826" Site 633 /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:238826" CDS 1..884 /gene="EST2" /locus_tag="YLR318W" /coded_by="NM_001182207.2:1..2655" /experiment="EXISTENCE:direct assay:GO:0000333 telomerase catalytic core complex [PMID:15813705]" /experiment="EXISTENCE:direct assay:GO:0003720 telomerase activity [PMID:15813705]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12101098]" /experiment="EXISTENCE:direct assay:GO:0005697 telomerase holoenzyme complex [PMID:10898986]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12101098]" /experiment="EXISTENCE:direct assay:GO:0007004 telomere maintenance via telomerase [PMID:10898986|PMID:15813705]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:17656141]" /experiment="EXISTENCE:mutant phenotype:GO:0003720 telomerase activity [PMID:9110970]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:15813705|PMID:8978029]" /note="Reverse transcriptase subunit of the telomerase holoenzyme; essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia" /db_xref="GeneID:851028" /db_xref="SGD:S000004310" ORIGIN 1 mkilfefiqd kldidlqtns tykenlkcgh fngldeiltt cfalpnsrki alpclpgdls 61 hkavidhcii ylltgelynn vltfgykiar nedvnnslfc hsanvnvtll kgaawkmfhs 121 lvgtyafvdl linytviqfn gqfftqivgn rcnephlppk waqrsssssa taaqikqlte 181 pvtnkqflhk lninsssffp yskilpssss ikkltdlrea ifptnlvkip qrlkvrinlt 241 lqkllkrhkr lnyvsilnsi cpplegtvld lshlsrqspk ervlkfiivi lqkllpqemf 301 gskknkgkii knlnlllslp lngylpfdsl lkklrlkdfr wlfisdiwft khnfenlnql 361 aicfiswlfr qlipkiiqtf fycteisstv tivyfrhdtw nklitpfive yfktylvenn 421 vcrnhnsytl snfnhskmri ipkksnnefr iiaipcrgad eeeftiyken hknaiqptqk 481 ileylrnkrp tsftkiyspt qiadrikefk qrllkkfnnv lpelyfmkfd vkscydsipr 541 mecmrilkda lknengffvr sqyffntntg vlklfnvvna srvpkpyely idnvrtvhls 601 nqdvinvvem eifktalwve dkcyiredgl fqgsslsapi vdlvyddlle fysefkasps 661 qdtlilklad dfliistdqq qvinikklam ggfqkynaka nrdkilavss qsdddtviqf 721 camhifvkel evwkhsstmn nfhirskssk gifrslialf ntrisyktid tnlnstntvl 781 mqidhvvkni secyksafkd lsinvtqnmq fhsflqriie mtvsgcpitk cdplieyevr 841 ftilngfles lssntskfkd niillrkeiq hlqayiyiyi hivn // LOCUS NP_013423 788 aa linear PLN 30-JUN-2025 DEFINITION formin-mediated actin nucleation enhancer [Saccharomyces cerevisiae S288C]. ACCESSION NP_013423 VERSION NP_013423.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182208.1 REFERENCE 1 (residues 1 to 788) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 788) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 788) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 788) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 788) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09628. Method: conceptual translation. FEATURES Location/Qualifiers source 1..788 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..788 /product="formin-mediated actin nucleation enhancer" /calculated_mol_wt="88686" Region 365..776 /region_name="AIP3" /note="Actin interacting protein 3; smart00806" /db_xref="CDD:214826" CDS 1..788 /gene="BUD6" /locus_tag="YLR319C" /gene_synonym="AIP3" /coded_by="NM_001182208.1:1..2367" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11071900|PMID:9247651]" /experiment="EXISTENCE:direct assay:GO:0000133 polarisome [PMID:9632790]" /experiment="EXISTENCE:direct assay:GO:0003779 actin binding [PMID:9247651|PMID:7719850]" /experiment="EXISTENCE:direct assay:GO:0005519 cytoskeletal regulatory protein binding [PMID:9082982]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:17416900]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:9247651|PMID:23671312|PMID:11071900]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:23671312|PMID:9247651|PMID:11071900]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807|PMID:9082982]" /experiment="EXISTENCE:direct assay:GO:0051127 positive regulation of actin nucleation [PMID:30076201]" /experiment="EXISTENCE:direct assay:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:14657240|PMID:15923184]" /experiment="EXISTENCE:direct assay:GO:0099503 secretory vesicle [PMID:30076201]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:17237521]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:23671312]" /experiment="EXISTENCE:genetic interaction:GO:0051127 positive regulation of actin nucleation [PMID:30076201]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:17237521]" /experiment="EXISTENCE:genetic interaction:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:14657240]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:9247651|PMID:8657162]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:24603354]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:23671312]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:9247651]" /experiment="EXISTENCE:mutant phenotype:GO:0030953 astral microtubule organization [PMID:22608510]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:10085294]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:17237521]" /experiment="EXISTENCE:mutant phenotype:GO:0051017 actin filament bundle assembly [PMID:23671312]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:17237521]" /experiment="EXISTENCE:physical interaction:GO:0005519 cytoskeletal regulatory protein binding [PMID:15923184]" /note="Actin- and formin-interacting protein; nucleation-promoting factor (NPF) for Bni1p and Bnr1p during actin cable assembly and organization; enhances Bnr1p-mediated actin nucleation, alleviating Hof1p inhibition through competitive binding; interacts with Bni1p via a C-terminal triple helical coiled-coil domain; role in polarized cell growth; isolated as a bipolar budding mutant; localizes to the presumptive bud site, small bud tips, the bud neck and secretory vesicles; potential Cdc28p substrate" /db_xref="GeneID:851029" /db_xref="SGD:S000004311" ORIGIN 1 mkmavddpty gtpkikrtas ssssiettvt kllmstkhll qvltqwskgt tsgrlvsday 61 vqlgndfkvv skffmhakvd msdvgdvpma lrrvlevtlr eppsdetlnk hlpkireiiv 121 tlldklkvkq ailknmqqeh risvkshhqq npsftsnlsl gsegtregtp lssrkssivr 181 dqrqsdsven sygekvnsts tgtpsaqsae atltkprtni kqnlksnnap nasddddals 241 qlkkgtnlqr raskrysayh makltnqstt eaaaaaglmt tpspsmlhle etvrksklyg 301 nnnndddrni nsaenkgksi ddvskaspla ktplpienvr asprrlssvv ttspdkamng 361 tcpvflrigd ktkkchvqlp ttknalrllf ierfayspga nsfpdiyimd pqygvfyele 421 elnlldikeg fvielkleen pnntikefid tvkmeisnsq ndiirhlkem sfgsaisgkq 481 tevlpqpgle ankhdlvgqn kkdddktikd iqyelgkikq vhninrsnin etifnilrkv 541 dnfkslsfsa knssnrmyme ksqtelgdls dtllskvddl qdvieimrkd vaerrsqpak 601 kkletvskdl enaqadvlkl qefidtekph wkktweaeld kvceeqqflt lqeelildlk 661 edlgkaletf dliklcceeq eknpsrsksn pilpimrpgt fnqvreqvmv avqslnpdhd 721 srveaidkae kmwemerklk asnefddele nfvgnsnlkk sggfeeveri rkqkdeanlr 781 ayfgpgft // LOCUS NP_013424 1454 aa linear PLN 30-JUN-2025 DEFINITION Mms22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013424 VERSION NP_013424.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182209.1 REFERENCE 1 (residues 1 to 1454) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1454) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1454) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1454) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09629. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1454 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1454 /product="Mms22p" /calculated_mol_wt="167553" Region 758..1218 /region_name="Mus7" /note="Mus7/MMS22 family; pfam09462" /db_xref="CDD:370511" CDS 1..1454 /gene="MMS22" /locus_tag="YLR320W" /gene_synonym="SLM2" /coded_by="NM_001182209.1:1..4365" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15718301]" /experiment="EXISTENCE:direct assay:GO:0035361 Cul8-RING ubiquitin ligase complex [PMID:20139071]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:18321796]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:20174551]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:20174551]" /experiment="EXISTENCE:mutant phenotype:GO:0031297 replication fork processing [PMID:18704118]" /experiment="EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:18069899]" /note="Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of replication fork, such as fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; Rtt101p-Mms22p ligase associates with replisome complex during S phase via Ctf4p; required for accurate meiotic chromosome segregation" /db_xref="GeneID:851030" /db_xref="SGD:S000004312" ORIGIN 1 mdvdepnpiv isdseatdee isiiyepefn enylwaeenv qeasrsqkiv terlsldsta 61 gesctpsvvt dtqvttglrw slrkrkaiqk mpyslerikh rqllegydis sfdsisnqlt 121 lpknastvih sndilltkrt gkpldeqkdv tidsikpens svqsqrydsd eeipkkrhrt 181 fkdldqdivf qsgdstedeq dlastnlqnt qndevifrgr vlnvrtgyrg vlprvaweks 241 lqkqqsskvt krktqllnhk gvakrkmnrs ahiedeeqnl lndliapdde ldieenappd 301 iylgnlpedr eanekelkel qeyyeskyse daqsagtsgf nlneeyrnep vyeleydgpg 361 scishvsykd qpiiylnsrh sdsgfseqyn isaednqsvi sldaaeehnd giidkmlvkp 421 krikatndan flntkskrvr rykykyrnsc lapstkaikv gkrsahkshl aannpvsfvs 481 kknhviddyf feelesqsle qddssslkpq kkrrkkkapi yssfsadles rrkpvfntvv 541 evptnryaft kpnvrnrdsi nhdmefeeed snqelgpimv vldsillkkp feppnffkiq 601 lsdksfllsk lnpadiatsl qkifrviidk gitdtelvhf nesliaflvh ldmpelfdli 661 gefhrefrsk vnslrkkakp ihffqiaacq lmfleisryn kisaaakfdm dvklldhivs 721 ffkllsvcyd svmknpmqyl ytsyyilsav vdvihkkeal wdlfqkhpfs phislllvni 781 fptkvcrwqv lrldsefqpl ssafrfinyc ietcnwnvtn slilsldrif krrrfsdfee 841 esdlsqnnki iypptnqlts rlmfnrylhl ltlcelsssd tqrvipmgdi smndslsvlk 901 nrlnllivla trfdlnlekr fqeltrplys keylnlhtqn tvrtittlim qaslsfleis 961 riknhpfsgk fiaslfdklv lqqpsisgvt enflkeftnl vskmkrksvs mlkflypslv 1021 amsqenifes sfflllqvyl ksldvlgptw vqnylfqfik skaqenerwi ecycqigkfl 1081 vdsgiftwwt fftyngldaa lhfqlafhsl iidfcdtdsf ellkkplysi asdllliskd 1141 dafyhflsnl lkrahiivad lkpvsdenel lrlayifska lkknayqdll avflslakkh 1201 ydegdisrnf lakyleflnk ncltelrnnq lfislrrelg issdedekca fwdsfneagd 1261 ilskaafvet givqacctgn eidgyldnls tlftstmles pfaffsdlvi ahifenrpff 1321 dvniknflls hfidlfnkvl kmkfeqvspd efaelckvyr alciecatdd tfnsnsdlia 1381 akdaflvsvl riadgfwehd kllqlrmlds nmnipnqiph ttlqsslsai vikiiesnig 1441 kieasepfkt fknt // LOCUS NP_013425 426 aa linear PLN 30-JUN-2025 DEFINITION Sfh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013425 VERSION NP_013425.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182210.1 REFERENCE 1 (residues 1 to 426) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 426) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 426) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 426) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09630. Method: conceptual translation. FEATURES Location/Qualifiers source 1..426 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..426 /product="Sfh1p" /calculated_mol_wt="48646" Region 204..391 /region_name="SNF5" /note="SNF5 / SMARCB1 / INI1; pfam04855" /db_xref="CDD:428158" CDS 1..426 /gene="SFH1" /locus_tag="YLR321C" /coded_by="NM_001182210.1:1..1281" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:31672915]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:31672915|PMID:10619019|PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:31672915]" /experiment="EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:12697820]" /experiment="EXISTENCE:genetic interaction:GO:0033262 regulation of nuclear cell cycle DNA replication [PMID:17542652]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16024655]" /experiment="EXISTENCE:mutant phenotype:GO:0031055 chromatin remodeling at centromere [PMID:12697820]" /note="Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog; hSNF5 tumor suppressor ortholog" /db_xref="GeneID:851032" /db_xref="SGD:S000004313" ORIGIN 1 mshqnqlipq ayisnfhnrl tneddgipif tmaqqtrqhk rakvvnyaey dndlfdefnm 61 ngsnfnnadt hykdnavshe ntpaltngvt mdgseynvle nmngadsiis nnkydagsnm 121 vveslsglns nnnasngpsn kaqaqdigna vlpdlqdqhh npfnilrypk irdtfingkv 181 vspyrlntdq etkanansge aimipitldi ehmghtikdq flwnynddsi speefasiyc 241 kdldmtsatl qtqianiike qlkdleniaa teimsdlhvi inltcnlqdr ffednfqwnl 301 ndksltperf atsivqdlgl trefiplisq slhetilkik kdwvdghliq dhvpndaafg 361 ylsgirldid elgsnwcprv eiltkeeiqk reiekernlr rlkretdrls rrgrrrlddl 421 ettmrm // LOCUS NP_013427 259 aa linear PLN 30-JUN-2025 DEFINITION U2-type spliceosomal complex subunit CWC24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013427 VERSION NP_013427.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182212.1 REFERENCE 1 (residues 1 to 259) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 259) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 259) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 259) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09631. Method: conceptual translation. FEATURES Location/Qualifiers source 1..259 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..259 /product="U2-type spliceosomal complex subunit CWC24" /calculated_mol_wt="29610" Region 1..259 /region_name="COG5152" /note="Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers [General function prediction only]" /db_xref="CDD:227481" CDS 1..259 /gene="CWC24" /locus_tag="YLR323C" /coded_by="NM_001182212.1:1..780" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17974558]" /experiment="EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]" /experiment="EXISTENCE:mutant phenotype:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:22535589]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:23029180]" /experiment="EXISTENCE:mutant phenotype:GO:0034247 snoRNA splicing [PMID:17974558|PMID:23029180]" /experiment="EXISTENCE:physical interaction:GO:0005681 spliceosomal complex [PMID:23029180]" /note="General splicing factor; required for stable U2 snRNP binding to primary transcripts; essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; similar to S. pombe Cwf24p" /db_xref="GeneID:851033" /db_xref="SGD:S000004315" ORIGIN 1 mfrkrlvnks ssdeknqkkr qkinfseekl vasdeekgss dlmslaksgn srtlqlshen 61 egklqkkged ldkytltvnd dstkedllnf erkelaekak krrpsddnel vlnmsgknkr 121 ltkqinqptn irttvlmdfq pdvckdykqt gycgygdsck flhsrddfkt gwklnqewna 181 dkedskavtl dlekipfkct lckedykspv vtncghyfcg scfakdmkkg tkcfichket 241 hgsakvasdl qkmlnkrks // LOCUS NP_013428 523 aa linear PLN 30-JUN-2025 DEFINITION peroxisome biogenesis protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013428 VERSION NP_013428.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182213.1 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09632. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..523 /product="peroxisome biogenesis protein" /calculated_mol_wt="59331" Region 61..403 /region_name="Pex24p" /note="Integral peroxisomal membrane peroxin; pfam06398" /db_xref="CDD:399414" CDS 1..523 /gene="PEX30" /locus_tag="YLR324W" /coded_by="NM_001182213.1:1..1572" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27129769|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:14617799]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:27129769|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071782 endoplasmic reticulum tubular network [PMID:27872254]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0032581 ER-dependent peroxisome organization [PMID:27129769]" /experiment="EXISTENCE:genetic interaction:GO:1900063 regulation of peroxisome organization [PMID:27872254]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:14617799]" /note="ER-resident protein involved in peroxisomal biogenesis; ER-localized protein that associates with peroxisomes; interacts with Pex29p and reticulons Rtn1p and Yop1p to regulate peroxisome biogenesis from the ER; role in peroxisomal-destined vesicular flow from the ER; partially redundant with Pex31p; may function at a step downstream of steps mediated by Pex28p and Pex29p; PEX30 has a paralog, PEX31, that arose from the whole genome duplication" /db_xref="GeneID:851034" /db_xref="SGD:S000004316" ORIGIN 1 msgnttnvhe trakfaetlq priggnttkv iraaleknea esgvsedndn gslekvnvat 61 splltstppt iskalvklyp ylilidefln vvtwtgkniw ssvlmlclfi ttveyfetlv 121 kyfghlaiia ilwgyslldn yiegtlsssp tlediallmn rvslksdill spmvnlgtqd 181 iqrllyttvi lspiyvmitw lllpprslml mvgmflltyh spwskvarrl lwkfkivrll 241 vfyvtgldlg ginkdqgifa tvqkqvkkla stensngvls dskpirftyv lyenqrrwlg 301 igwkpsmlsy ertpwtdefl neapspenfh lpeetntmvw rwvdktwrld mtndgaiqvp 361 nskartsadp spdegfiyyd ntwkkpsked sfskytrrrr wvrtaelvkt sdfdesvins 421 nrnsaieqkv eenstnglta eqelgsnkqe kdnakkvgep tteetkefae asninegefe 481 risstdeevl ksrardrlak vlddteekeq snptigrdsk kav // LOCUS NP_013429 78 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL38 RPL38 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013429 VERSION NP_013429.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182214.1 REFERENCE 1 (residues 1 to 78) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 78) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 78) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 78) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09633. Method: conceptual translation. FEATURES Location/Qualifiers source 1..78 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..78 /product="60S ribosomal protein eL38 RPL38" /calculated_mol_wt="8695" Region 3..75 /region_name="Ribosomal_L38e" /note="Ribosomal L38e protein family; pfam01781" /db_xref="CDD:460326" CDS 1..78 /gene="RPL38" /locus_tag="YLR325C" /coded_by="NM_001182214.1:1..237" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L38; homologous to mammalian ribosomal protein L38, no bacterial homolog" /db_xref="GeneID:851035" /db_xref="SGD:S000004317" ORIGIN 1 mareitdikq fleltrradv ktatvkinkk lnkagkpfrq tkfkvrgsss lytlvindag 61 kakkliqslp ptlkvnrl // LOCUS NP_013430 240 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR326W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013430 VERSION NP_013430.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182215.1 REFERENCE 1 (residues 1 to 240) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 240) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 240) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 240) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09634. Method: conceptual translation. FEATURES Location/Qualifiers source 1..240 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..240 /product="uncharacterized protein" /calculated_mol_wt="27292" Region 62..166 /region_name="DUF4112" /note="Domain of unknown function (DUF4112); pfam13430" /db_xref="CDD:433200" CDS 1..240 /locus_tag="YLR326W" /coded_by="NM_001182215.1:1..723" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the cell periphery; predicted to be palmitoylated" /db_xref="GeneID:851036" /db_xref="SGD:S000004318" ORIGIN 1 msgfikstll glgqdyledq yqefaeqhfq ptrdpfyetn kdgkkhrrrl pyyctkdesk 61 awkkvqnkaw lhdkslcgcc cwtntigwap llallpvigp llmywvhdkl ieladdrykl 121 paeikvkmhg nividllisl vpilgsvfaw lhacstrnaa ivynfvgkra lerkqaelmh 181 qkeenekhsn antappvvgg nknvngnrnn skmynrppvt appapaytrs tngrpqrgyr // LOCUS NP_013431 86 aa linear PLN 30-JUN-2025 DEFINITION Tma10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013431 VERSION NP_013431.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182216.1 REFERENCE 1 (residues 1 to 86) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 86) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 86) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 86) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09635. Method: conceptual translation. FEATURES Location/Qualifiers source 1..86 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..86 /product="Tma10p" /calculated_mol_wt="9703" Region 30..>51 /region_name="HABP4_PAI-RBP1" /note="Hyaluronan / mRNA binding family; pfam04774" /db_xref="CDD:461421" CDS 1..86 /gene="TMA10" /locus_tag="YLR327C" /gene_synonym="SFL2" /coded_by="NM_001182216.1:1..261" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein that associates with ribosomes; protein abundance increases in response to DNA replication stress; TMA10 has a paralog, STF2, that arose from the whole genome duplication" /db_xref="GeneID:851037" /db_xref="SGD:S000004319" ORIGIN 1 mtrtskwtvh eaksnpkyft hngnfgespn hvkrggygkg nwgkpgdein dlidsgeikt 61 vfnktrrgsn sqnnerrlsd lqqyhi // LOCUS NP_013432 401 aa linear PLN 30-JUN-2025 DEFINITION nicotinamide-nucleotide adenylyltransferase NMA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013432 VERSION NP_013432.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182217.1 REFERENCE 1 (residues 1 to 401) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 401) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 401) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 401) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09636. Method: conceptual translation. FEATURES Location/Qualifiers source 1..401 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..401 /product="nicotinamide-nucleotide adenylyltransferase NMA1" /EC_number="2.7.7.1" /EC_number="2.7.7.18" /calculated_mol_wt="45728" Region 166..386 /region_name="NMNAT_Eukarya" /note="Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic; cd09286" /db_xref="CDD:185681" Site order(170..174,178,180..181,184,285,287..288,290,353) /site_type="active" /db_xref="CDD:185681" Site 178..181 /site_type="other" /note="(T/H)XGH motif" /db_xref="CDD:185681" CDS 1..401 /gene="NMA1" /locus_tag="YLR328W" /coded_by="NM_001182217.1:1..1206" /experiment="EXISTENCE:direct assay:GO:0000309 nicotinamide-nucleotide adenylyltransferase activity [PMID:10428462]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009435 NAD+ biosynthetic process [PMID:10428462]" /note="Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways; homolog of human NMNAT; NMA1 has a paralog, NMA2, that arose from the whole genome duplication" /db_xref="GeneID:851039" /db_xref="SGD:S000004320" ORIGIN 1 mdptrapdfk ppsadeelip ppdpeskipk sipiipyvla danssidapf nikrkkkhpk 61 hhhhhhhsrk egndkkhqhi plnqddfqpl saevsseddd adfrskeryg sdsttesetr 121 gvqkyqiadl eevphgivrq artledyefp shrlskklld pnklplviva cgsfspityl 181 hlrmfemald aiseqtrfev iggyyspvsd nyqkqglaps yhrvrmcela certsswlmv 241 daweslqpsy trtakvldhf nheinikrgg vatvtgekig vkimllaggd liesmgepnv 301 wadadlhhil gnygcliver tgsdvrsfll shdimyehrr niliikqliy ndisstkvrl 361 firramsvqy llpnsviryi qehrlyvdqt epvkqvlgnk e // LOCUS NP_013433 264 aa linear PLN 30-JUN-2025 DEFINITION Rec102p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013433 VERSION NP_013433.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182218.1 REFERENCE 1 (residues 1 to 264) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 264) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 264) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 264) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09637. On Jan 23, 2006 this sequence version replaced NP_013433.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..264 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..264 /product="Rec102p" /calculated_mol_wt="30106" CDS 1..264 /gene="REC102" /locus_tag="YLR329W" /coded_by="NM_001182218.1:1..795" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:15044957]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:1732169]" /note="Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination" /db_xref="GeneID:851040" /db_xref="SGD:S000004321" ORIGIN 1 marditfltv flescgavnn deagkllsaw tstvriegpe stdsnslyip llppgmlkik 61 lnfkmndrlv teeqelftkl reivgssirf weeqlfyqvq dvstienhvi lslkctiltd 121 aqistfiskp relhthakgy peiyylsels ttvnffskeg nyveisqvip hfneyfssli 181 vsqlefeypm vfsmisrlrl kwqqsslapi syaltsnsvl lpimlnmiaq dkssttayqi 241 lcrrrgppiq nfqifslpav tynk // LOCUS NP_013434 671 aa linear PLN 30-JUN-2025 DEFINITION Chs5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013434 VERSION NP_013434.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182219.1 REFERENCE 1 (residues 1 to 671) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 671) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 671) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 671) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09638. Method: conceptual translation. FEATURES Location/Qualifiers source 1..671 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..671 /product="Chs5p" /calculated_mol_wt="73508" Region 4..76 /region_name="Chs5_N" /note="N-terminal dimerization domain of Chs5 and similar proteins; cd13945" /db_xref="CDD:260117" Site order(4,6..7,26,28..31,33..34,36,43..52,55..56) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:260117" Site order(11..13,19,21,25..27,33,59,62..63,66..67,70..71, 73..76) /site_type="other" /note="Bch1 interaction interface [polypeptide binding]" /db_xref="CDD:260117" Site order(11..12,21,25..26,40..42,56,60,63..64,66..67,70..71, 73..76) /site_type="other" /note="Chs6 interaction interface [polypeptide binding]" /db_xref="CDD:260117" Region 77..165 /region_name="fn3_2" /note="Fibronectin type III domain; pfam16893" /db_xref="CDD:435634" Site order(79,139,154) /site_type="active" /note="Interdomain contacts [active]" /db_xref="CDD:238020" Region 172..255 /region_name="BRCT_CHS5_like" /note="BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; cd17742" /db_xref="CDD:349373" Region 290..>599 /region_name="PRK08581" /note="amidase domain-containing protein" /db_xref="CDD:236304" Region <446..618 /region_name="rne" /note="ribonuclease E; Reviewed; PRK10811" /db_xref="CDD:236766" CDS 1..671 /gene="CHS5" /locus_tag="YLR330W" /gene_synonym="CAL3" /coded_by="NM_001182219.1:1..2016" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141|PMID:9008706]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006355 regulation of DNA-templated transcription [PMID:17000877]" /experiment="EXISTENCE:direct assay:GO:0034044 exomer complex [PMID:23000721|PMID:17000877]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:16498409]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:9111317]" /experiment="EXISTENCE:mutant phenotype:GO:0006032 chitin catabolic process [PMID:9111317]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:11879634|PMID:16498409]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:9111317]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:16498409]" /note="Component of the exomer complex; the exomer which also contains Csh6p, Bch1p, Bch2p, and Bud7, is involved in the export of select proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; Chs5p is the only protein with a BRCT domain that is not localized to the nucleus" /db_xref="GeneID:851041" /db_xref="SGD:S000004322" ORIGIN 1 mssvdvlltv gkldaslall ttqdhhvief ptvllpenvk agsiikmqvs qnleeekkqr 61 nhfksiqaki lekygthkpe spvlkivnvt qtscvlawdp lklgsaklks lilyrkgirs 121 mvipnpfkvt ttkisglsvd tpyefqlkli ttsgtlwsek vilrthkmtd msgitvclgp 181 ldplkeisdl qisqclshig arplqrhvai dtthfvcndl dneesneeli rakhnnipiv 241 rpewvracev ekrivgvrgf yldadqsilk nytfppvnee elsyskenep vaevadenkm 301 pedttdveqv aspndnesnp seakeqgeks ghetapvspv edplhastal enettietvn 361 psvrslksep vgtpnieenk adssaeavve epneavaess pneeatgqks edtdthsneq 421 adngfvqtee vaennittes agennepadd aamefgrpea eietpevnes iedanepaed 481 snepvedsnk pvkdsnkpve dsnkpvedsn kpvedsnkpv edanepvedt sepvedagep 541 vqetnefttd iasprhqeed ieleaepkda tesvavepsn edvkpeekgs eaeddinnvs 601 keaasgestt hqkteasasl essavteeqe tteaevntdd vlstkeakkn tgnsnsnkkk 661 nkknkkkgkk k // LOCUS NP_001335801 125 aa linear PLN 30-JUN-2025 DEFINITION Jip3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335801 VERSION NP_001335801.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348861.1 REFERENCE 1 (residues 1 to 125) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 125) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 125) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 125) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 125) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80321. Method: conceptual translation. FEATURES Location/Qualifiers source 1..125 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..125 /product="Jip3p" /calculated_mol_wt="14414" CDS 1..125 /gene="JIP3" /locus_tag="YLR331C" /coded_by="NM_001348861.1:1..378" /note="hypothetical protein; conserved among S. cerevisiae strains; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2" /db_xref="GeneID:851043" /db_xref="SGD:S000004323" ORIGIN 1 mekdeedees eeaeeellvl esdeklndvn dmeamlvdel vcdtrdlldv devredesal 61 eeetilddkm eleeltllte eravdtaeef edddctknca rivdmhdsik snkrklflvv 121 kdnil // LOCUS NP_013436 376 aa linear PLN 30-JUN-2025 DEFINITION Mid2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013436 VERSION NP_013436.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182221.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09639. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..376 /product="Mid2p" /calculated_mol_wt="39015" Region 179..312 /region_name="Mid2" /note="Mid2 like cell wall stress sensor; pfam04478" /db_xref="CDD:398266" CDS 1..376 /gene="MID2" /locus_tag="YLR332W" /gene_synonym="KAI1" /coded_by="NM_001182221.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10348843]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006970 response to osmotic stress [PMID:14871941]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:10348843]" /experiment="EXISTENCE:genetic interaction:GO:1903139 positive regulation of cell integrity MAPK cascade [PMID:12949174]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20385774]" /experiment="EXISTENCE:mutant phenotype:GO:0004888 transmembrane signaling receptor activity [PMID:10330137]" /experiment="EXISTENCE:mutant phenotype:GO:0010447 response to acidic pH [PMID:16087742]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:11014808]" /experiment="EXISTENCE:mutant phenotype:GO:0036498 IRE1-mediated unfolded protein response [PMID:18971375]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:24460703]" /note="O-glycosylated plasma membrane protein; acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p; MID2 has a paralog, MTL1, that arose from the whole genome duplication" /db_xref="GeneID:851042" /db_xref="SGD:S000004324" ORIGIN 1 mlsfttknsf rllllilsci stiraqffvq ssssnssavs tarssvsrvs ssssilsssm 61 vssssadsss ltsstssrsl vshtssstsi asisftsfsf ssdsstssss sassdsssss 121 sfsisstsat sesstsstqt stssssslss tpssssspst itsapstsst psttaynqgs 181 titsiingkt ilsnhyttvt ytpsatadss nkskssglsk knrnivigcv vgigvplilv 241 ilaliymfci qssrtdfids dgkvvtayra nkftkwwyml lgkkvsdeyh sdsplggsas 301 saggldldea ddvmeqsslf dvrirdsdsv lpnantadhn ntnsggepin ssvasndiie 361 ekfydeqgne lsprny // LOCUS NP_013437 108 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS25 RPS25B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013437 VERSION NP_013437.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182222.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09640. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..108 /product="40S ribosomal protein eS25 RPS25B" /calculated_mol_wt="11878" Region <25..103 /region_name="Ribosomal_S25" /note="S25 ribosomal protein; pfam03297" /db_xref="CDD:460876" CDS 1..108 /gene="RPS25B" /locus_tag="YLR333C" /coded_by="NM_001182222.1:1..327" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S25, no bacterial homolog; RPS25B has a paralog, RPS25A, that arose from the whole genome duplication" /db_xref="GeneID:851045" /db_xref="SGD:S000004325" ORIGIN 1 mppkqqlska akaaaalagg kkskkkwskk smkdraqhav ildqekydri lkevptyryv 61 svsvlvdrlk iggslarial rhlekegiik piskhskqai ytraaase // LOCUS NP_013439 720 aa linear PLN 30-JUN-2025 DEFINITION nucleoporin NUP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013439 VERSION NP_013439.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182224.1 REFERENCE 1 (residues 1 to 720) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 720) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 720) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 720) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09641. Method: conceptual translation. FEATURES Location/Qualifiers source 1..720 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..720 /product="nucleoporin NUP2" /calculated_mol_wt="77750" Region 2..71 /region_name="NUP50" /note="NUP50 (Nucleoporin 50 kDa); pfam08911" /db_xref="CDD:462629" Region 233..>486 /region_name="PRK08581" /note="amidase domain-containing protein" /db_xref="CDD:236304" Region 588..715 /region_name="RanBD" /note="Ran-binding domain; smart00160" /db_xref="CDD:197549" CDS 1..720 /gene="NUP2" /locus_tag="YLR335W" /coded_by="NM_001182224.1:1..2163" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006607 NLS-bearing protein import into nucleus [PMID:11046143|PMID:11867631]" /experiment="EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:11425876]" /experiment="EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:10725229|PMID:11425876]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]" /experiment="EXISTENCE:genetic interaction:GO:0006611 protein export from nucleus [PMID:10542277]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:11387327]" /experiment="EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20932479]" /experiment="EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:11046143]" /experiment="EXISTENCE:mutant phenotype:GO:0006611 protein export from nucleus [PMID:11046143|PMID:10542277|PMID:10725229]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:21036941]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:21818277]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:16365162]" /experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]" /experiment="EXISTENCE:mutant phenotype:GO:0036228 protein localization to nuclear inner membrane [PMID:16929305]" /experiment="EXISTENCE:physical interaction:GO:0006611 protein export from nucleus [PMID:10725229]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:10525531|PMID:11046143|PMID:12917401|PMID:17418788]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:7638224]" /note="Nucleoporin involved in nucleocytoplasmic transport; binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization; involved with Nup60p in nuclear basket remodeling during meiosis; Cdc5p-mediated phosphorylation of Nup60p leads to detachment and reattachment of nuclear basket" /db_xref="GeneID:851048" /db_xref="SGD:S000004327" ORIGIN 1 makrvadaqi qretydsnes dddvtpstkv assavmnrrk iampkrrmaf kpfgsaksde 61 tkqassfsfl nradgtgeaq vdnspttesn srlkalnlqf kakvddlvlg kpladlrplf 121 tryelyikni leapvksien ptqtkgndak pakvedvqks sdsssedevk vegpkftida 181 kppisdsvfs fgpkkenrkk desdsendie ikgpefkfsg tvssdvfkln pstdknekkt 241 etnakpfsfs satstteqtk sknplsltea tktnvdnnsk aeasftfgtk haadsqnnkp 301 sfvfgqaaak pslekssftf gsttiekknd enstsnskpe kssdsndsnp sfsfsipskn 361 tpdaskpsfs fgvpnsskne tskpvfsfga atpsakeasq eddnnnvekp sskpafnlis 421 nagtekekes kkdskpafsf gisngseskd sdkpslpsav dgendkkeat kpafsfgint 481 nttktadtka ptftfgssal adnkedvkkp fsfgtsqpnn tpsfsfgktt anlpanssts 541 papsipstgf kfslpfeqkg sqtttndske estteatgne sqdatkvdat peeskpinlq 601 ngeedevalf sqkaklmtfn aetksydsrg vgemkllkkk ddpskvrllc rsdgmgnvll 661 natvvdsfky eplapgndnl ikaptvaadg klvtyivkfk qkeegrsftk aiedakkemk // LOCUS NP_013440 899 aa linear PLN 30-JUN-2025 DEFINITION Sgd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013440 VERSION NP_013440.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182225.1 REFERENCE 1 (residues 1 to 899) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 899) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 899) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 899) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09642. Method: conceptual translation. FEATURES Location/Qualifiers source 1..899 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..899 /product="Sgd1p" /calculated_mol_wt="102722" Region <23..337 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" Region 336..540 /region_name="MIF4G" /note="MIF4G domain; pfam02854" /db_xref="CDD:397130" Region 645..771 /region_name="MA3" /note="MA3 domain; pfam02847" /db_xref="CDD:397128" CDS 1..899 /gene="SGD1" /locus_tag="YLR336C" /coded_by="NM_001182225.1:1..2700" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11042259]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11042259]" /experiment="EXISTENCE:genetic interaction:GO:0006972 hyperosmotic response [PMID:11042259|PMID:12073033]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:19806183]" /experiment="EXISTENCE:physical interaction:GO:0097078 FAL1-SGD1 complex [PMID:21576267]" /note="Essential nuclear protein; required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia" /db_xref="GeneID:851049" /db_xref="SGD:S000004328" ORIGIN 1 mqktdgirip gvildelktl dysqderfsi segkkrrrgn gkhlsrkekr kmeradkkrk 61 iistreinss rlksaptsek rsanagvknv gkqangknpi ssdesesnen wdsdevltde 121 vaeesgeqam saeetmkkle slkrkakgiq gaensgeikg nsyekkhirn rdtnenfvsy 181 plapsdrsaf erdemdmqyy akklglkger kaihakdefd aiggllegle yfenygksde 241 eygdfatetn smrkddease kafssdddls asdfedsdgl sesdndsvad sddnyrreke 301 npyvaptqsv esyvppslrk klddsennst lseiskkvns slnklsdsni tiiitdlnrl 361 ydslprqyvt esltkgilni isqnqklldg fimnyaalay tlsklrgiev gaffiqktve 421 aflhhyeeem enilkdqqsk isskicinia tllsycynfg fvscrliydi irifvadpne 481 fttelllrii sisgqlirgd dpsalrdirs ellknaknlk eqsprlrflm dtmsdlknnr 541 lkpsilatdh hplkknlqsi lnsssswepl qvsledikni dskgkwwlvg aswrgnmena 601 fevsinnend askskkskis ieddllddip dwniiarqqr mntdirraif isimsaqdyl 661 dafsklekls lknkqvleip rivlhcllad sgsngynhyy alvankicer yshlsksfqf 721 lfwdvikkfe dkefdsesdt deeddlddke kllrisnqgr ffgsllandi lkldvfkhvp 781 fmgglntegm lfmeillfql fltvakksek klkmdesgnk riiysddylr dvltknvkse 841 nmlfilkglk wfinkkfryh nflagkkgdk afdrderrla waskaaksii dkelenids // LOCUS NP_013441 817 aa linear PLN 30-JUN-2025 DEFINITION Vrp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013441 VERSION NP_013441.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182226.1 REFERENCE 1 (residues 1 to 817) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 817) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 817) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 817) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 817) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09643. Method: conceptual translation. FEATURES Location/Qualifiers source 1..817 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..817 /product="Vrp1p" /calculated_mol_wt="82463" Region 27..55 /region_name="WH2_WAS_WASL" /note="Wiskott Aldrich syndrome homology region 2 (WH2 motif) in WAS/WASL-interacting protein (WIP); cd22064" /db_xref="CDD:409207" Site order(27..31,33..35,37..39,44..48,50..55) /site_type="other" /note="actin-binding motif [polypeptide binding]" /db_xref="CDD:409207" Region 44..47 /region_name="actin-binding sequence" /note="actin-binding sequence [structural motif]" /db_xref="CDD:409207" Region <109..>240 /region_name="PRK12323" /note="DNA polymerase III subunit gamma/tau; cl46901" /db_xref="CDD:481241" CDS 1..817 /gene="VRP1" /locus_tag="YLR337C" /gene_synonym="END5; MDP2; YLR337W" /coded_by="NM_001182226.1:1..2454" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9412475]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:9412475]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:9412475|PMID:16824951]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:11604421|PMID:16824951]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8590801|PMID:9742397]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:9412475]" /experiment="EXISTENCE:mutant phenotype:GO:0032465 regulation of cytokinesis [PMID:15941409]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:8590801]" /experiment="EXISTENCE:physical interaction:GO:0003779 actin binding [PMID:9412475]" /note="Verprolin, proline-rich actin-associated protein; involved in cytoskeletal organization and cytokinesis; promotes actin nucleation and endocytosis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP)" /db_xref="GeneID:851051" /db_xref="SGD:S000004329" ORIGIN 1 magapapppp ppppalggsa pkpaksvmqg rdallgdirk gmklkkaetn drsapivggg 61 vvssasgssg tvsskgpsms appipgmgap qlgdilaggi pklkhinnna stkpspsasa 121 ppipgavpsv aappipnapl spapavpsip sssappipdi pssaappipi vpsspapplp 181 lsgasapkvp qnrphmpsvr pahrshqrks snislpsvsa pplpsaslpt hvsnppqapp 241 ppptptigld sknikptdna vsppssevpa gglpflaein arrsergave gvsstkiqte 301 nhkspsqppl pssappipts happlpptap pppslpnvts apkkatsapa ppppplpaam 361 ssastnsvka tpvpptlapp lpnttsvppn kassmpappp ppppppgafs tssalsassi 421 plaplppppp psvatsvpsa ppppptlttn kpsasskqsk isssssssav tpggplpfla 481 eiqkkrddrf vvggdtgytt qdkqedvigs skddnvrpsp ispsinppkq ssqngmsfld 541 eiesklhkqt ssnafnappp htdamapplp psappppits lptptasgdd htndksetvl 601 gmkkakapal pghvppppvp pvlsddsknn vpaasllhdv lpssnlekpp sppvaaappl 661 ptfsapslpq qsvstsipsp ppvaptlsvr tetesisknp tkspppppsp stmdtgtsns 721 psknlkqrlf stggstlqhk hnthtnqpdv dvgrytiggs nsivgaksgn erividdsrf 781 kwtnvsqmpk prpfqnktkl ypsgkgssvp ldltlft // LOCUS NP_013444 312 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL10 RPP0 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013444 VERSION NP_013444.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182229.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09644. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..312 /product="60S ribosomal protein uL10 RPP0" /calculated_mol_wt="33586" Region 5..312 /region_name="Ribosomal_L10_P0" /note="Ribosomal protein L10 family; composed of the large subunit ribosomal protein called L10 in bacteria, P0 in eukaryotes, and L10e in archaea, as well as uncharacterized P0-like eukaryotic proteins. In all three kingdoms, L10 forms a tight complex with...; cl00376" /db_xref="CDD:469747" Site order(8..9,12,55..58,61) /site_type="other" /note="23S rRNA interface [nucleotide binding]" /db_xref="CDD:240221" Site order(94,114,118,137,140..141,144..145,147..150,168..170, 173..174,176..177,179) /site_type="other" /note="putative Interface with L7/L12 ribosomal proteins [polypeptide binding]" /db_xref="CDD:240221" CDS 1..312 /gene="RPP0" /locus_tag="YLR340W" /gene_synonym="RPL10E" /coded_by="NM_001182229.1:1..939" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19797078]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0070180 large ribosomal subunit rRNA binding [PMID:16164560]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:8195220]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:8195220]" /note="Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10" /db_xref="GeneID:851052" /db_xref="SGD:S000004332" ORIGIN 1 mggirekkae yfaklreyle eykslfvvgv dnvssqqmhe vrkelrgrav vlmgkntmvr 61 rairgflsdl pdfekllpfv kgnvgfvftn eplteiknvi vsnrvaapar agavapediw 121 vravntgmep gktsffqalg vptkiargti eivsdvkvvd agnkvgqsea sllnllnisp 181 ftfgltvvqv ydngqvfpss ilditdeelv shfvsavsti asislaigyp tlpsvghtli 241 nnykdllava iaasyhypei edlvdrienp ekyaaaapaa tsaasgdaap aeeaaaeeee 301 esdddmgfgl fd // LOCUS NP_013445 477 aa linear PLN 30-JUN-2025 DEFINITION Spo77p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013445 VERSION NP_013445.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182230.1 REFERENCE 1 (residues 1 to 477) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 477) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 477) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 477) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09645. Method: conceptual translation. FEATURES Location/Qualifiers source 1..477 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..477 /product="Spo77p" /calculated_mol_wt="55007" CDS 1..477 /gene="SPO77" /locus_tag="YLR341W" /coded_by="NM_001182230.1:1..1434" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15590821]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]" /experiment="EXISTENCE:mutant phenotype:GO:1903024 positive regulation of ascospore-type prospore membrane formation [PMID:27182947]" /note="Meiosis-specific hypothetical protein; required for spore wall formation during sporulation and for timely prospore membrane closure along with SPS1; required with Sps1p for phosphorylation and turnover of Ssp1p; dispensable for both nuclear divisions during meiosis" /db_xref="GeneID:851054" /db_xref="SGD:S000004333" ORIGIN 1 mfrrgdnsnf nvqnsfflpl eyeytvkdnv pskkkssigf fplddslfts knnsghhkse 61 qlhrgnaeti rsqfgtdavp iridekegkw driqddnssn lnyqinnsnd passgkytqs 121 idcnhiaesk fskkngnids lrsnsatfml ntadedvief sfddnvpyae llsgatlekc 181 sltlneinkk lfntlydfrv skdnpeenlv elilpncvvl lnffediell adssdeafek 241 stfintiefi vhdiwvetli kninllqmfd adlkcyndky iicklkgqyp stnivdimcr 301 lkhfsnsile tfkfgielke qdqchnrnti inyvlfsrvf stivleiqkc filivkfmys 361 vnflekfsde vflsfieili kivfehqipq lflgideiiq lwlknnegkr qqllsawcng 421 tvqdmkqsqq ressnaeses itssteedee glqfnkwdvi epfidnikal nqskshm // LOCUS NP_013446 1876 aa linear PLN 30-JUN-2025 DEFINITION 1,3-beta-D-glucan synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013446 VERSION NP_013446.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182231.1 REFERENCE 1 (residues 1 to 1876) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1876) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1876) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1876) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09646. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1876 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1876 /product="1,3-beta-D-glucan synthase" /EC_number="2.4.1.34" /calculated_mol_wt="214721" Region <18..80 /region_name="RCR" /note="Chitin synthesis regulation, resistance to Congo red; pfam12273" /db_xref="CDD:432443" Region 300..409 /region_name="FKS1_dom1" /note="1,3-beta-glucan synthase subunit FKS1, domain-1; pfam14288" /db_xref="CDD:464126" Region 808..1631 /region_name="Glucan_synthase" /note="1,3-beta-glucan synthase component; pfam02364" /db_xref="CDD:426739" CDS 1..1876 /gene="FKS1" /locus_tag="YLR342W" /gene_synonym="CND1; CWH53; ETG1; GSC1; PBR1" /coded_by="NM_001182231.1:1..5631" /experiment="EXISTENCE:direct assay:GO:0000148 1,3-beta-D-glucan synthase complex [PMID:7983071]" /experiment="EXISTENCE:direct assay:GO:0003843 1,3-beta-D-glucan synthase activity [PMID:7649185|PMID:7528927]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17507646|PMID:11856368]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11856368|PMID:8602515]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:8602515|PMID:11856368]" /experiment="EXISTENCE:direct assay:GO:0006075 (1->3)-beta-D-glucan biosynthetic process [PMID:7528927]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:11856368]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0003843 1,3-beta-D-glucan synthase activity [PMID:7528927]" /experiment="EXISTENCE:mutant phenotype:GO:0006075 (1->3)-beta-D-glucan biosynthetic process [PMID:7528927]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:17302939]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:14593073]" /note="Catalytic subunit of 1,3-beta-D-glucan synthase; transfers glucose from UDP-glucose to growing chains of glucan via beta-1,3-glycosidic linkages, translocating polymerized beta-1,3-glucan to the extracellular space; role in cell wall synthesis and maintenance; functionally redundant with alternate catalytic subunit Gsc2p; activity regulated by Rho1p, a subunit of the synthase complex; localizes to sites of cell wall remodeling; contains a cellulose-synthase-like fold; antifungal drug target" /db_xref="GeneID:851055" /db_xref="SGD:S000004334" ORIGIN 1 mntdqqpyqg qtdytqgpgn gqsqeqdydq ygqplypsqa dgyydpnvaa gteadmygqq 61 ppnesydqdy tngeyygqpp nmaaqdgenf sdfssygppg tpgydsyggq ytasqmsyge 121 pnssgtstpi ygnydpnaia malpnepypa wtadsqspvs ieqiedifid ltnrlgfqrd 181 smrnmfdhfm vlldsrssrm spdqallslh adyiggdtan ykkwyfaaql dmddeigfrn 241 mslgklsrka rkakkknkka meeanpedte etlnkiegdn sleaadfrwk akmnqlsple 301 rvrhialyll cwgeanqvrf taeclcfiyk caldyldspl cqqrqepmpe gdflnrvitp 361 iyhfirnqvy eivdgrfvkr erdhnkivgy ddlnqlfwyp egiakivled gtklielple 421 erylrlgdvv wddvffktyk etrtwlhlvt nfnriwvmhi sifwmyfayn sptfythnyq 481 qlvdnqplaa ykwascalgg tvasliqiva tlcewsfvpr kwagaqhlsr rfwflciifg 541 inlgpiifvf aydkdtvyst aahvvaavmf fvavatiiff simplgglft symkkstrry 601 vasqtftaaf aplhgldrwm sylvwvtvfa akysesyyfl vlslrdpiri lsttamrctg 661 eywwgavlck vqpkivlglv iatdfilffl dtylwyiivn tifsvgksfy lgisiltpwr 721 niftrlpkri yskilattdm eikykpkvli sqvwnaiiis myrehllaid hvqkllyhqv 781 pseiegkrtl raptffvsqd dnnfeteffp rdseaerris ffaqslstpi peplpvdnmp 841 tftvltphya erillslrei ireddqfsrv tlleylkqlh pvewecfvkd tkilaeetaa 901 yegneneaek edalksqidd lpfycigfks aapeytlrtr iwaslrsqtl yrtisgfmny 961 sraikllyrv enpeivqmfg gnaeglerel ekmarrkfkf lvsmqrlakf kphelenaef 1021 llraypdlqi ayldeepplt egeepriysa lidghceild ngrrrpkfrv qlsgnpilgd 1081 gksdnqnhal ifyrgeyiql idanqdnyle eclkirsvla efeelnveqv npyapglrye 1141 eqttnhpvai vgareyifse nsgvlgdvaa gkeqtfgtlf artlsqiggk lhyghpdfin 1201 atfmttrggv skaqkglhln ediyagmnam lrggrikhce yyqcgkgrdl gfgtilnftt 1261 kigagmgeqm lsreyyylgt qlpvdrfltf yyahpgfhln nlfiqlslqm fmltlvnlss 1321 lahesimciy drnkpktdvl vpigcynfqp avdwvrrytl sifivfwiaf vpivvqelie 1381 rglwkatqrf fchllslspm fevfagqiys sallsdlaig garyistgrg fatsripfsi 1441 lysrfagsai ymgarsmlml lfgtvahwqa pllwfwasls slifapfvfn phqfawedff 1501 ldyrdyirwl srgnnqyhrn swigyvrmsr aritgfkrkl vgdesekaag dasrahrtnl 1561 imaeiipcai yaagcfiaft finaqtgvkt tdddrvnsvl riiictlapi avnlgvlffc 1621 mgmsccsgpl fgmcckktgs vmagiahgva vivhiaffiv mwvlesfnfv rmligvvtci 1681 qcqrlifhcm talmltrefk ndhantafwt gkwygkgmgy mawtqpsrel takvielsef 1741 aadfvlghvi licqlpliii pkidkfhsim lfwlkpsrqi rppiyslkqt rlrkrmvkky 1801 cslyflvlai fagciigpav asakihkhig dsldgvvhnl fqpinttnnd tgsqmstyqs 1861 hyythtpslk twstik // LOCUS NP_878133 57 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR342W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878133 VERSION NP_878133.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184569.1 REFERENCE 1 (residues 1 to 57) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 57) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 57) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 57) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09647. Method: conceptual translation. FEATURES Location/Qualifiers source 1..57 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..57 /product="uncharacterized protein" /calculated_mol_wt="6428" CDS 1..57 /locus_tag="YLR342W-A" /coded_by="NM_001184569.1:1..174" /note="hypothetical protein" /db_xref="GeneID:1466421" /db_xref="SGD:S000028571" ORIGIN 1 mnvfmpirvf lysyviinsl lssffhqyrp lfikngaafg vsnsekicvt livneli // LOCUS NP_013447 555 aa linear PLN 30-JUN-2025 DEFINITION 1,3-beta-glucanosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013447 VERSION NP_013447.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182232.1 REFERENCE 1 (residues 1 to 555) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 555) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 555) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 555) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09648. Method: conceptual translation. FEATURES Location/Qualifiers source 1..555 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..555 /product="1,3-beta-glucanosyltransferase" /calculated_mol_wt="62231" Region 25..344 /region_name="Glyco_hydro_72" /note="Glucanosyltransferase; pfam03198" /db_xref="CDD:397351" Region 397..473 /region_name="X8" /note="X8 domain; pfam07983" /db_xref="CDD:400371" CDS 1..555 /gene="GAS2" /locus_tag="YLR343W" /coded_by="NM_001182232.1:1..1668" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0042124 1,3-beta-glucanosyltransferase activity [PMID:17397106]" /experiment="EXISTENCE:direct assay:GO:0070880 fungal-type cell wall beta-glucan biosynthetic process [PMID:19097997]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:17189486]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:17189486]" /note="1,3-beta-glucanosyltransferase; involved with Gas4p in spore wall assembly; has similarity to Gas1p" /db_xref="GeneID:851056" /db_xref="SGD:S000004335" ORIGIN 1 mnkkqnfyaa iivaiflclq lshgssgvsf ektpaikivg nkffdsesge qffikgiayq 61 lqrseeelsn angafetsyi daladpkicl rdipflkmlg vntlrvyaid ptkshdicme 121 alsaegmyvl ldlsepdisi nrenpswdvh iferyksvid amssfpnllg yfagnevtnd 181 htntfaspfv kaairdakey ishsnhrkip vgystnddam trdnlaryfv cgdvkadfyg 241 inmyewcgys tygtsgyrer tkefegypip vffsefgcnl vrprpftevs alygnkmssv 301 wsgglaymyf eeeneygvvk indndgvdil pdfknlkkef akadpkgite eeyltakept 361 evesvecphi avgvweanek lpetpdrskc acldeilpce ivpfgaesgk yeeyfsylcs 421 kvdcsdilan gktgeygefs dcsveqklsl qlsklyckig andrhcplnd knvyfnlesl 481 qpltsesick nvfdsirnit ynhgdysksn psrskeslnv kypsseeren dgtiafktsg 541 fvillismia agill // LOCUS NP_013448 127 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL24 RPL26A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013448 VERSION NP_013448.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182233.1 REFERENCE 1 (residues 1 to 127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 127) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09649. Method: conceptual translation. FEATURES Location/Qualifiers source 1..127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..127 /product="60S ribosomal protein uL24 RPL26A" /calculated_mol_wt="14103" Region 9..122 /region_name="Ribosomal_L26" /note="Ribosomal proteins L26 eukaryotic, L24P archaeal; pfam16906" /db_xref="CDD:465307" CDS 1..127 /gene="RPL26A" /locus_tag="YLR344W" /coded_by="NM_001182233.1:1..384" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:9672752|PMID:18782943]" /note="Ribosomal 60S subunit protein L26A; binds to 5.8S rRNA; non-essential even when paralog is also deleted; deletion has minimal affections on ribosome biosynthesis; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26A has a paralog, RPL26B, that arose from the whole genome duplication" /db_xref="GeneID:851058" /db_xref="SGD:S000004336" ORIGIN 1 makqsldvss drrkarkayf tapssqrrvl lsaplskelr aqygikalpi rrddevlvvr 61 gskkgqegki ssvyrlkfav qvdkvtkekv ngasvpinlh psklvitklh ldkdrkaliq 121 rkggkle // LOCUS NP_013449 509 aa linear PLN 30-JUN-2025 DEFINITION bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013449 VERSION NP_013449.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182234.1 REFERENCE 1 (residues 1 to 509) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 509) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 509) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 509) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 509) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 509) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 509) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 509) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 509) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09650. Method: conceptual translation. FEATURES Location/Qualifiers source 1..509 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..509 /product="bifunctional fructose-2,6-bisphosphate 2-phosphatase/6-phosphofructo-2-kinase" /EC_number="2.7.1.105" /EC_number="3.1.3.46" /calculated_mol_wt="58255" Region 71..291 /region_name="6PF2K" /note="6-phosphofructo-2-kinase; pfam01591" /db_xref="CDD:396253" Region 294..466 /region_name="PGAM" /note="Phosphoglycerate mutase family; smart00855" /db_xref="CDD:214859" Site order(298..299,370,459..460) /site_type="active" /note="catalytic core [active]" /db_xref="CDD:132718" CDS 1..509 /locus_tag="YLR345W" /coded_by="NM_001182234.1:1..1530" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Similar to 6-phosphofructo-2-kinase enzymes; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene" /db_xref="GeneID:851059" /db_xref="SGD:S000004337" ORIGIN 1 mpnvlsddee llnglgseim kpsrqgnhma rtvkrwvnke rattadlknv nidgvhgpvn 61 tesyispgql ystdsgnlfh agrilvvlvg lpatsktlls vaitrytrwl gvrtksfhfs 121 eykesaknip sdyfcvvpts kegvafvekl rmqmlndila ffndlsgqla iydalnirki 181 drknlettfs eigvkvlfie sivsdqeimn rnialalesn dykglstdea ideymrrlsv 241 nepyyemmth deelsyikyi nlgkqiivkd nihgylvnki vfflmnlrqk kgcvyfarcg 301 tsdkdnyihd eelneegihy sqvlkdfvlq rikqkrqakk nsdslvevid gshdedlkts 361 livwtgprkr thdtalffsk egikvqqrse lrqlnpgsia dltdqqimdk fpseykeslk 421 dpyhfrfpra esyhdlavrm eplllemeht skdiliiahe stlrvlygyl mactcvelpn 481 lnftrdklve isfspfcntv ellniplts // LOCUS NP_013450 101 aa linear PLN 30-JUN-2025 DEFINITION Cis1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013450 VERSION NP_013450.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182235.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09651. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..101 /product="Cis1p" /calculated_mol_wt="11217" CDS 1..101 /gene="CIS1" /locus_tag="YLR346C" /coded_by="NM_001182235.1:1..306" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="hypothetical protein found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; not an essential gene; YLR346C has a paralog, YGR035C, that arose from the whole genome duplication" /db_xref="GeneID:851060" /db_xref="SGD:S000004338" ORIGIN 1 mqsisncpig lvskntinsa stiaewvacp wkyinvvgsg ryvsnkpdki trydllkaaq 61 eaemqelltr ndmkgrhkrn kkskialeti aeensstesl f // LOCUS NP_013451 861 aa linear PLN 30-JUN-2025 DEFINITION karyopherin beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_013451 VERSION NP_013451.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182236.1 REFERENCE 1 (residues 1 to 861) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 861) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 861) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 861) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09652. Method: conceptual translation. FEATURES Location/Qualifiers source 1..861 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..861 /product="karyopherin beta" /calculated_mol_wt="94645" Region 1..861 /region_name="KAP95" /note="Karyopherin (importin) beta [Intracellular trafficking and secretion]; COG5215" /db_xref="CDD:227540" Region 135..164 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(153..154,157,160..161,164,199..200,203,206..207,214, 242..243,246,252..253,284..285,288,291..292) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 180..215 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 224..253 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 264..293 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 326..357 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(349..350,353,356..357,387..388,391,394..395,398, 429..430,433,436..437,440,471..472,475,478..479,518..519, 522,525..526) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 370..398 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 411..441 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 454..479 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 496..527 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..861 /gene="KAP95" /locus_tag="YLR347C" /gene_synonym="RSL1" /coded_by="NM_001182236.1:1..2586" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:19549784]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0042564 NLS-dependent protein nuclear import complex [PMID:19141610]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0046822 regulation of nucleocytoplasmic transport [PMID:29146254]" /experiment="EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:7622450]" /experiment="EXISTENCE:genetic interaction:GO:0006656 phosphatidylcholine biosynthetic process [PMID:19141610]" /experiment="EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:23131016|PMID:19141610]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:16929305]" /experiment="EXISTENCE:mutant phenotype:GO:0006656 phosphatidylcholine biosynthetic process [PMID:19141610]" /experiment="EXISTENCE:mutant phenotype:GO:0051292 nuclear pore complex assembly [PMID:17182855]" /experiment="EXISTENCE:mutant phenotype:GO:0060188 regulation of protein desumoylation [PMID:17403926]" /note="Karyopherin beta; forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p" /db_xref="GeneID:851061" /db_xref="SGD:S000004339" ORIGIN 1 mstaefaqll ensilspdqn irltsetqlk klsndnflqf aglssqvlid entklegril 61 aaltlknelv skdsvktqqf aqrwitqvsp eaknqiktna ltalvsiepr ianaaaqlia 121 aiadielphg awpelmkimv dntgaeqpen vkrasllalg ymcesadpqs qalvsssnni 181 liaivqgaqs tetskavrla alnaladsli fiknnmereg ernylmqvvc eatqaediev 241 qaaafgclck imslyytfmk pymeqalyal tiatmkspnd kvasmtvefw sticeeeidi 301 ayelaqfpqs plqsynfals sikdvvpnll nlltrqnedp edddwnvsms agaclqlfaq 361 ncgnhilepv lefveqnita dnwrnreaav mafgsimdgp dkvqrtyyvh qalpsilnlm 421 ndqslqvket tawcigriad svaesidpqq hlpgvvqacl iglqdhpkva tncswtiinl 481 veqlaeatps piynfypalv dgligaanri dnefnarasa fsalttmvey atdtvaetsa 541 sistfvmdkl gqtmsvdenq ltledaqslq elqsniltvl aavirkspss vepvadmlmg 601 lffrllekkd safieddvfy aisalaaslg kgfekyletf spyllkalnq vdspvsitav 661 gfiadisnsl eedfrrysda mmnvlaqmis npnarrelkp avlsvfgdia snigadfipy 721 lndimalcva aqntkpengt lealdyqikv leavldayvg ivaglhdkpe alfpyvgtif 781 qfiaqvaedp qlysedatsr aavgligdia amfpdgsikq fygqdwvidy ikrtrsgqlf 841 sqatkdtarw areqqkrqls l // LOCUS NP_013452 298 aa linear PLN 30-JUN-2025 DEFINITION Dic1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013452 VERSION NP_013452.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182237.1 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09653. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..298 /product="Dic1p" /calculated_mol_wt="32861" Region 20..94 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 100..200 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 203..289 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..298 /gene="DIC1" /locus_tag="YLR348C" /coded_by="NM_001182237.1:1..897" /experiment="EXISTENCE:direct assay:GO:0005310 dicarboxylic acid transmembrane transporter activity [PMID:9020177|PMID:9559855]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:15591051]" /experiment="EXISTENCE:direct assay:GO:0006835 dicarboxylic acid transport [PMID:9020177|PMID:9559855]" /note="Mitochondrial dicarboxylate carrier; integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix" /db_xref="GeneID:851063" /db_xref="SGD:S000004340" ORIGIN 1 mstnakesag knikypwwyg gaagifatmv thpldlakvr lqaapmpkpt lfrmlesila 61 negvvglysg lsaavlrqct yttvrfgayd llkenvipre qltnmayllp csmfsgaigg 121 lagnfadvvn irmqndsale aakrrnykna idgvykiyry egglktlftg wkpnmvrgil 181 mtasqvvtyd vfknylvtkl dfdasknyth ltasllaglv attvcspadv mktrimngsg 241 dhqpalkila davrkegpsf mfrgwlpsft rlgpftmlif faieqlkkhr vgmpkedk // LOCUS NP_013454 216 aa linear PLN 30-JUN-2025 DEFINITION sphingolipid homeostasis protein ORM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013454 VERSION NP_013454.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182239.1 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09654. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..216 /product="sphingolipid homeostasis protein ORM2" /calculated_mol_wt="24724" Region 37..216 /region_name="COG5081" /note="Predicted membrane protein [Function unknown]" /db_xref="CDD:227413" CDS 1..216 /gene="ORM2" /locus_tag="YLR350W" /coded_by="NM_001182239.1:1..651" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20182505|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0017059 serine palmitoyltransferase complex [PMID:20182505]" /experiment="EXISTENCE:genetic interaction:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:20182505]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:12093374]" /experiment="EXISTENCE:mutant phenotype:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:20182505]" /experiment="EXISTENCE:mutant phenotype:GO:0090156 intracellular sphingolipid homeostasis [PMID:31368600]" /note="Protein that mediates sphingolipid homeostasis; evolutionarily conserved, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress; ORM2 has a paralog, ORM1, that arose from the whole genome duplication" /db_xref="GeneID:851064" /db_xref="SGD:S000004342" ORIGIN 1 midrtknesp afeespltpn vsnlkpfpsq snkistpvtd hrrrrsssvi shveqetfed 61 endqqmlpnm natwvdqrga wlihivvivl lrlfyslfgs tpkwtwtltn mtyiigfyim 121 fhlvkgtpfd fnggaydnlt mweqindetl ytptrkflli vpivlflisn qyyrndmtlf 181 lsnlavtvli gvvpklgith rlrisipgit graqis // LOCUS NP_013455 291 aa linear PLN 30-JUN-2025 DEFINITION putative hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013455 VERSION NP_013455.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182240.1 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09655. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..291 /product="putative hydrolase" /EC_number="3.5.1.3" /calculated_mol_wt="32418" Region 12..281 /region_name="nit" /note="Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); cd07572" /db_xref="CDD:143596" Site order(53,111,128,132,144,169..170,172..173,194) /site_type="active" /note="putative active site [active]" /db_xref="CDD:143596" Site order(53,128,169) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:143596" Site order(129..130,150..152,170,173..177,179..180,202..203, 206..207,209..211,213..214,244,274..275,278..279,281) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:143596" CDS 1..291 /gene="NIT3" /locus_tag="YLR351C" /coded_by="NM_001182240.1:1..876" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [PMID:28373563]" /experiment="EXISTENCE:direct assay:GO:0043605 amide catabolic process [PMID:28373563]" /note="Nit protein; one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member" /db_xref="GeneID:851065" /db_xref="SGD:S000004343" ORIGIN 1 msaskilsqk ikvalvqlsg sspdkmanlq raatfieram keqpdtklvv lpecfnspys 61 tdqfrkysev inpkepstsv qflsnlankf kiilvggtip eldpktdkiy ntsiifnedg 121 klidkhrkvh lfdvdipngi sfhesetlsp geksttidtk ygkfgvgicy dmrfpelaml 181 sarkgafami ypsafntvtg plhwhllars ravdnqvyvm lcsparnlqs syhayghsiv 241 vdprgkivae agegeeiiya eldpeviesf rqavpltkqr rfdvysdvna h // LOCUS NP_013456 807 aa linear PLN 30-JUN-2025 DEFINITION Lug1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013456 VERSION NP_013456.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182241.1 REFERENCE 1 (residues 1 to 807) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 807) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 807) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 807) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09656. Method: conceptual translation. FEATURES Location/Qualifiers source 1..807 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..807 /product="Lug1p" /calculated_mol_wt="92992" Region 171..198 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 215..240 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 241..265 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 266..300 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 301..333 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 336..379 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" CDS 1..807 /gene="LUG1" /locus_tag="YLR352W" /coded_by="NM_001182241.1:1..2424" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:11283612]" /note="hypothetical protein with similarity to F-box proteins; interacts with the core SCF ubiquitin ligase complex subunits Skp1p and Cdc53p; LUG1 deletion prevents cells containing the [URE3] prion or lacking Ure2p from growing on glycerol" /db_xref="GeneID:851066" /db_xref="SGD:S000004344" ORIGIN 1 mpdlksktls sqslgaaipp eivyqiltyq frdllrndhp gtaekfnenl ttfvksnltv 61 nktfshicqv liyrycnltt akrfhgllqt lkgnrclcnk ievadfqelt siglgrssem 121 nkmiknltne tlleflmltk anlreflace niqddlddni ikyilspgkv lsvvdfcgcs 181 gttftesfik aldkyypnks idqyrlepiq qnyqitclgl ndcidlpshv lwkilkmlpe 241 lqkldlshts iddstlyhgi phwknlthls latclqvtpr avleffshhp titdpdntst 301 lewlnvsvia hssswnevht mfllkklcqh ghnktlqyln igglplhvap sfgedpises 361 tyyyqcrdsl qfikwnfpkl kslsikgnsi pistlveflt pidqdhpnca qklkflnisg 421 nsyvnkwtiq dsllytcsps lvalevsfds wqqieklndr heiiayrykn pnsvikdist 481 aeqvkwkcyi dssygrrywl yktdpflnrd dldsksnltr ydfeghkiie iinqpdflkf 541 aqskimlgcg lvpqsgirrk lcyrdlkppv sqflnrkgai slgdtplpii tptlprggwr 601 iihneddnns hvedsqnhvn aiprrnslls rptlrsnngs ssanpfainv spasqirdgl 661 ywdrsvhdlr elslqeqriq eladeqqelr tianfeetdd eylhdpdlqr rrsqlhlfes 721 srsrsgnktr psltgehsss asflsfshfn hlhkrknyyf thpdefvydp kdplttqryr 781 lhfeivneyq vfgciergmy ryyslka // LOCUS NP_013457 603 aa linear PLN 30-JUN-2025 DEFINITION Bud8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013457 VERSION NP_013457.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182242.1 REFERENCE 1 (residues 1 to 603) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 603) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 603) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 603) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09657. Method: conceptual translation. FEATURES Location/Qualifiers source 1..603 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..603 /product="Bud8p" /calculated_mol_wt="66158" CDS 1..603 /gene="BUD8" /locus_tag="YLR353W" /coded_by="NM_001182242.1:1..1812" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11514631]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11514631]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:8657162]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:17581861]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]" /note="Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole; BUD8 has a paralog, BUD9, that arose from the whole genome duplication" /db_xref="GeneID:851067" /db_xref="SGD:S000004345" ORIGIN 1 miqsdednld ssettastsy sgtssvssrl qlrtslffen lngahgnpda etematvaye 61 ttsrgqgfav yinnerfsqi mgastsssss snsssitqfh dtqdnnipsn ttvrptslrr 121 dnedtvplrn vtpsqnaavr peravnspss qrlscaltis tsvlmgedve gspieqehsr 181 vvsslyssla nrgndeskng tpprptsiep nettehsffs yhyddtlepd veeavrltkn 241 ktsnvnfiss tgskgegete devidqyepv neskfiphkl kipekagsik sstsddshsp 301 gapgtsarki kipqspslig nilipshnsd ssnesspkdh ighnneekfs skstrkpsts 361 leeegppigl psipvlrsvs gpskwtktpl rlesgnstks dpfsryeghk tpspltkmnk 421 kknktlpehg qplvlapiks qssesdtgqn siiekparsi rrkqqektdn rkedrhdaen 481 idlearmpiq hidtasihsf dsgqngfrdv ysieniivil lccsivpplf fiigcssrrk 541 lvsdyrlmrl lmnkehraal lqgfiwdvdl rwfrmfclil gaaetvivma giaigfgvgi 601 tre // LOCUS NP_013458 335 aa linear PLN 30-JUN-2025 DEFINITION sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013458 VERSION NP_013458.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182243.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09658. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..335 /product="sedoheptulose-7-phosphate:D-glyceraldehyde-3- phosphate transaldolase TAL1" /EC_number="2.2.1.2" /calculated_mol_wt="36905" Region 14..333 /region_name="talAB" /note="transaldolase; TIGR00874" /db_xref="CDD:162081" Site order(29,45,47..48,106,108,144,167,169,189,194) /site_type="active" /db_xref="CDD:188644" Site order(116,295,298,302..303,309,312,316) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:188644" Site 144 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:188644" CDS 1..335 /gene="TAL1" /locus_tag="YLR354C" /coded_by="NM_001182243.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0004801 transaldolase activity [PMID:2185015]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17397208]" /experiment="EXISTENCE:mutant phenotype:GO:0006098 pentose-phosphate shunt [PMID:8299150]" /note="Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate; TAL1 has a paralog, NQM1, that arose from the whole genome duplication" /db_xref="GeneID:851068" /db_xref="SGD:S000004346" ORIGIN 1 msepaqkkqk vannsleqlk asgtvvvadt gdfgsiakfq pqdsttnpsl ilaaakqpty 61 aklidvavey gkkhgkttee qvenavdrll vefgkeilki vpgrvstevd arlsfdtqat 121 iekarhiikl feqegvsker vlikiastwe giqaakelee kdgihcnltl lfsfvqavac 181 aeaqvtlisp fvgrildwyk sstgkdykge adpgvisvkk iynyykkygy ktivmgasfr 241 stdeiknlag vdyltispal ldklmnstep fprvldpvsa kkeagdkisy isdeskfrfd 301 lnedamatek lsegirkfsa divtlfdlie kkvta // LOCUS NP_013459 395 aa linear PLN 30-JUN-2025 DEFINITION ketol-acid reductoisomerase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013459 VERSION NP_013459.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182244.1 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09659. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..395 /product="ketol-acid reductoisomerase" /EC_number="1.1.1.86" /calculated_mol_wt="44237" Region 75..395 /region_name="ilvC" /note="ketol-acid reductoisomerase; TIGR00465" /db_xref="CDD:273093" CDS 1..395 /gene="ILV5" /locus_tag="YLR355C" /coded_by="NM_001182244.1:1..1188" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:18023287]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:18193418|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10869431]" /experiment="EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:18826960]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:7621838]" /experiment="EXISTENCE:mutant phenotype:GO:0004455 ketol-acid reductoisomerase activity [PMID:14124940|PMID:3027658]" /experiment="EXISTENCE:mutant phenotype:GO:0009082 branched-chain amino acid biosynthetic process [PMID:14124940]" /note="Acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids" /db_xref="GeneID:851069" /db_xref="SGD:S000004347" ORIGIN 1 mlrtqaarli cnsrvitakr tfalatraaa ysrpaarfvk pmittrglkq infggtvetv 61 yeradwprek lldyfkndtf aligygsqgy gqglnlrdng lnviigvrkd gaswkaaied 121 gwvpgknlft vedaikrgsy vmnllsdaaq setwpaikpl ltkgktlyfs hgfspvfkdl 181 thveppkdld vilvapkgsg rtvrslfkeg rginssyavw ndvtgkahek aqalavaigs 241 gyvyqttfer evnsdlyger gclmggihgm flaqydvlre nghspseafn etveeatqsl 301 ypligkygmd ymydacstta rrgaldwypi fknalkpvfq dlyestkngt etkrslefns 361 qpdyreklek eldtirnmei wkvgkevrkl rpenq // LOCUS NP_013460 197 aa linear PLN 30-JUN-2025 DEFINITION Atg33p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013460 VERSION NP_013460.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182245.1 REFERENCE 1 (residues 1 to 197) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 197) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 197) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09660. Method: conceptual translation. FEATURES Location/Qualifiers source 1..197 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..197 /product="Atg33p" /calculated_mol_wt="20269" CDS 1..197 /gene="ATG33" /locus_tag="YLR356W" /coded_by="NM_001182245.1:1..594" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762|PMID:24769239|PMID:14562095|PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /note="Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes; ATG33 has a paralog, SCM4, that arose from the whole genome duplication" /db_xref="GeneID:851070" /db_xref="SGD:S000004348" ORIGIN 1 msvclaitkg iavssiglys gllasaslit sttplevltg sltptlttlk naatalgafa 61 stffcvsffg appslrhpyl lygmlvapls sfvlgcasny qsrkyskvsk esslfpedsk 121 laaselsdsi idlgednhas entprdgkpa attvskpaea lhtgppihtk nliaataiai 181 vgfvqavigv ygegqfi // LOCUS NP_013461 889 aa linear PLN 30-JUN-2025 DEFINITION Rsc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013461 VERSION NP_013461.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182246.1 REFERENCE 1 (residues 1 to 889) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 889) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 889) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 889) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 889) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09661. Method: conceptual translation. FEATURES Location/Qualifiers source 1..889 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..889 /product="Rsc2p" /calculated_mol_wt="102169" Region 17..121 /region_name="Bromo_Rsc1_2_I" /note="Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two...; cd05521" /db_xref="CDD:99952" Site order(47,52,55,92,96,102) /site_type="other" /note="putative acetyllysine binding site [chemical binding]" /db_xref="CDD:99952" Region 123..503 /region_name="COG5076" /note="Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]" /db_xref="CDD:227408" CDS 1..889 /gene="RSC2" /locus_tag="YLR357W" /coded_by="NM_001182246.1:1..2670" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23907388]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:12183366|PMID:10619019]" /experiment="EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:14729968]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:16024655]" /experiment="EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:14729968]" /experiment="EXISTENCE:mutant phenotype:GO:0070914 UV-damage excision repair [PMID:24360959]" /experiment="EXISTENCE:physical interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15870268]" /note="Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance; RSC2 has a paralog, RSC1, that arose from the whole genome duplication" /db_xref="GeneID:851071" /db_xref="SGD:S000004349" ORIGIN 1 mmpddnsnss tqnssalykd lrkeyeslft lkedsgleis pifnvlppkk dypdyyavik 61 npvsfntlkk riphytdaqq fmndvvqipw naktyntrds giykyalvle kylkdtiypn 121 lkekypqlvy pdlgplpdep gyeefqqklr ekaeevaran aaraessssm nsteaarrlr 181 ktrtsvkres epgtdtnnde dyeatdmdid npkdadfpdl irkplininp ytrkplrdnr 241 sttpshsgtp qplgprhrqv srtqvkrgrp piidlpyiqr mknvmkvlkk evldsgiglt 301 dlferlpdrh rdanyyimia npislqdink kvktrryktf qefqndfnlm ltnfrishrg 361 dpesikisni lektftslar felskpdrsf ipegelrypl devivnnisy hvgdwallrn 421 qndpqkpivg qifrlwktpd gkqwlnacwy yrpeqtvhrv drlfyknevm ktgqyrdhlv 481 snlvgkcyvi hftryqrgnp dmklegplfv cefrynesdk ifnkirtwka clpeeirdld 541 eatipvngrk ffkypspirh llpanatphd rvpeptmgsp dapplvgavy mrpkmqrddl 601 geyatsddcp ryiirpndsp eegqvdietg tittntptan alpktgysss klsslrynrs 661 smslenqnai gqqqiplsrv gspgaggplt vqglkqhqlq rlqqqqhqyq qqkrsqasry 721 niptiiddlt sqasrgnlgn imidaassfv lpisitknvd vlqrtdlhsq tkrsgreemf 781 pwkktkgeil wfrgpsvivn eriinsgdph lslplnrwft tnkkrkleye eveetmedvt 841 gkdkdddgle pdvenekesl pgpfvlglrp sakftahrls mlrppssss // LOCUS NP_001257685 187 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR358C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257685 VERSION NP_001257685.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270756.1 REFERENCE 1 (residues 1 to 187) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 187) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 187) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 187) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35125. Method: conceptual translation. FEATURES Location/Qualifiers source 1..187 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..187 /product="uncharacterized protein" /calculated_mol_wt="20152" CDS 1..187 /locus_tag="YLR358C" /coded_by="NM_001270756.1:1..564" /note="hypothetical protein; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W" /db_xref="GeneID:851072" /db_xref="SGD:S000004350" ORIGIN 1 mrngkilcch cfynkgdhed deggrsiesl cavnlaegln prtngpgkds fsfstsgskp 61 ssslsfpvts smvsstssys sflfllvvnh lfsgrlrcgs pefiirsfti tlgplnhnis 121 pfvffhgnis slpdllvwlc rsvrcktstf lvieigktne eaasiiilpk lpldacdvks 181 siivgil // LOCUS NP_013463 482 aa linear PLN 30-JUN-2025 DEFINITION adenylosuccinase ADE13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013463 VERSION NP_013463.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182248.1 REFERENCE 1 (residues 1 to 482) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 482) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 482) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 482) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09662. Method: conceptual translation. FEATURES Location/Qualifiers source 1..482 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..482 /product="adenylosuccinase ADE13" /EC_number="4.3.2.2" /calculated_mol_wt="54380" Region 11..449 /region_name="Adenylsuccinate_lyase_2" /note="Adenylsuccinate lyase (ASL)_subgroup 2; cd03302" /db_xref="CDD:176471" Site order(25..26,84,93,102..103,105..106,154..159,161,167..168, 171,174..175,181..182,198..201,204,233,235..236,243,247, 254,261,265,267..268,270..271,293..294,299,303,306..307, 309..310,313..314,317..318,322..328,332..333,335,340,380, 384,387,393..394,447,449) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:176471" Site order(83,104,156,238,292,294,299) /site_type="active" /db_xref="CDD:176471" CDS 1..482 /gene="ADE13" /locus_tag="YLR359W" /gene_synonym="BRA1; BRA8" /coded_by="NM_001182248.1:1..1449" /experiment="EXISTENCE:genetic interaction:GO:0006189 'de novo' IMP biosynthetic process [PMID:7896125]" /experiment="EXISTENCE:mutant phenotype:GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [PMID:7896125|PMID:5807803]" /experiment="EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:5807803]" /experiment="EXISTENCE:mutant phenotype:GO:0006189 'de novo' IMP biosynthetic process [PMID:5807803]" /note="Adenylosuccinate lyase; catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency; human ADSL can complement yeast ADE13 null mutant" /db_xref="GeneID:851073" /db_xref="SGD:S000004351" ORIGIN 1 mpdydnyttp lssryaskem satfslrnrf stwrklwlnl aiaekelglt vvtdeaieqm 61 rkhveitdde iakasaqeai vrhdvmahvh tfgetcpaaa giihlgatsc fvtdnadlif 121 irdaydiiip klvnvinrla kfameykdlp vlgwthfqpa qlttlgkrat lwiqellwdl 181 rnferarndi glrgvkgttg tqasflalfh gnhdkveald ervtellgfd kvypvtgqty 241 srkididvla plssfaatah kmatdirlla nlkeveepfe ksqigssama ykrnpmrcer 301 vcslarhlgs lfsdavqtas vqwfertldd sairrislps afltadills tllnissglv 361 vypkvierri kgelpfmate niimamvekn asrqevheri rvlshqaaav vkeeggendl 421 iervkrdeff kpiweeldsl lepstfvgra pqqvekfvqk dvnnalqpfq kylndeqvkl 481 nv // LOCUS NP_013464 439 aa linear PLN 30-JUN-2025 DEFINITION Vps38p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013464 VERSION NP_013464.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182249.3 REFERENCE 1 (residues 1 to 439) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 439) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 439) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 439) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09663. On Jul 30, 2012 this sequence version replaced NP_013464.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..439 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..439 /product="Vps38p" /calculated_mol_wt="50729" Region 1..436 /region_name="VPS38" /note="Vacuolar protein sorting 38; pfam17649" /db_xref="CDD:435943" CDS 1..439 /gene="VPS38" /locus_tag="YLR360W" /gene_synonym="VPL17" /coded_by="NM_001182249.3:1..1320" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II [PMID:11157979]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:32788210]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:11157979|PMID:9265642]" /experiment="EXISTENCE:mutant phenotype:GO:0051365 cellular response to potassium ion starvation [PMID:32788210]" /note="Part of a Vps34p phosphatidylinositol 3-kinase complex; functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:851074" /db_xref="SGD:S000004352" ORIGIN 1 mkrfllsrrq rhlrmicfhn islfrangds klikeygdgf ipcffilesi rgellyvsev 61 qsgslrklsf qelpkltgas tmivlklvgl vpsdilctis sdkngiiddk wcvlctytid 121 lnklqpined tvlitgtnap vldlidgsyt laaekikplk glvsshkrni sqvkikfsla 181 yssllklnkl leyssqvhee ineisskied dflslknqnh wymrtvqksi etlekevlqr 241 kkskkniema qlesndtinh sktelslmsq desinddygs iysrfvqikd rldqlrfkkl 301 yqligifhst dlfnsdrgyi yfekpssvnd vinrlklkpl nieillrqag estkhreyvn 361 sqlgyyllfl hltaiqifka plpyrlmyyg stsvidsqyp lyftdqmisk hqaklikaih 421 yfnadilqfk qilenyrpt // LOCUS NP_013465 578 aa linear PLN 30-JUN-2025 DEFINITION phosphoprotein phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013465 VERSION NP_013465.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182250.1 REFERENCE 1 (residues 1 to 578) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 578) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 578) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 578) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09664. Method: conceptual translation. FEATURES Location/Qualifiers source 1..578 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..578 /product="phosphoprotein phosphatase" /calculated_mol_wt="66332" Region 246..518 /region_name="MPP_Dcr2" /note="Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; cd07383" /db_xref="CDD:277329" Site order(255,257,302,337..338,444,498,500) /site_type="active" /note="putative active site [active]" /db_xref="CDD:277329" Site order(255,257,302,337,444,498,500) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:277329" CDS 1..578 /gene="DCR2" /locus_tag="YLR361C" /coded_by="NM_001182250.1:1..1737" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:17673172|PMID:16990850]" /experiment="EXISTENCE:genetic interaction:GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response [PMID:16990850]" /experiment="EXISTENCE:mutant phenotype:GO:0004721 phosphoprotein phosphatase activity [PMID:17673172]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:15590836]" /experiment="EXISTENCE:mutant phenotype:GO:0016788 hydrolase activity, acting on ester bonds [PMID:15590836]" /experiment="EXISTENCE:mutant phenotype:GO:1900102 negative regulation of endoplasmic reticulum unfolded protein response [PMID:16990850]" /note="Protein phosphatase; involved in downregulation of the unfolded protein response (UPR), at least in part through dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START; physically interacts with, dephosphorylates and destabilizes Sic1p; SWAT-GFP and mCherry fusion proteins localize to the vacuole" /db_xref="GeneID:851075" /db_xref="SGD:S000004353" ORIGIN 1 mirlprlyqr yllylvvfvv ialfyflqap rveehigfdl alpishvdnl wfqnkglegf 61 snddklvvni gydecfhigr fyegcfnrhe lkstltdghq ylqrkrihkd lrgsfgrrwf 121 gkseylyydv lypalvdyfg snleklnvea vtgiskypkd kslpfmdvsi tfepisiell 181 qkrsyisdin ilfgvdciqp ianwtlqkef plvkyrysep ayltykfvgt rpvdtgaqrl 241 qetdegkfki vqladlhlgv gesecideyp kheackadpk tetfvqqvld iekpqlvvft 301 gdqimgdrsi qdsetvllka vapviarkip wamvwgnhdd egsltrwqls eiasvlpysl 361 fkfsphdthd ntfgvgnyiy qifsnndtev pvgtlyflds hkystvgkiy pgydwikesq 421 wkyiedyhdv nlkfktglsm affhiplpey lnieskthpg eknpligmyk egvtapkyns 481 egittldrls vdvvscghdh cndyclrdds tpnkiwlcyg ggggeggyag yggterriri 541 yeinvnenni htwkrlngsp keifdfqsml dgnspesv // LOCUS NP_878134 98 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR361C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878134 VERSION NP_878134.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184659.3 REFERENCE 1 (residues 1 to 98) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 98) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 98) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 98) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09665. On Jul 30, 2012 this sequence version replaced NP_878134.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..98 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..98 /product="uncharacterized protein" /calculated_mol_wt="10919" CDS 1..98 /locus_tag="YLR361C-A" /coded_by="NM_001184659.3:1..297" /note="hypothetical protein" /db_xref="GeneID:1466422" /db_xref="SGD:S000028845" ORIGIN 1 mavsnnnnnn nskertqnik eveeklgenp kitlkgggkt kimdfeqlrk phcvrpsarf 61 pvedtaggll rtgghrpqis deevskrhhe qshgqedh // LOCUS NP_013466 717 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase kinase kinase STE11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013466 VERSION NP_013466.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182251.1 REFERENCE 1 (residues 1 to 717) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 717) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 717) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 717) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 717) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09666. Method: conceptual translation. FEATURES Location/Qualifiers source 1..717 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..717 /product="mitogen-activated protein kinase kinase kinase STE11" /EC_number="2.7.11.25" /calculated_mol_wt="80590" Region 20..82 /region_name="SAM_Ste11_fungal" /note="SAM domain of Ste11_fungal subfamily; cd09534" /db_xref="CDD:188933" Site order(24,27,38,42,47,76..82) /site_type="other" /note="putative heterodimer interface [polypeptide binding]" /db_xref="CDD:188933" Site order(54,56..59,61..62,68..69,71..72,75..76) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:188933" Site order(54,59,62) /site_type="other" /note="heterodimer interface ML [polypeptide binding]" /db_xref="CDD:188933" Region 121..224 /region_name="Ras_bdg_2" /note="Ras-binding domain of Byr2; pfam14847" /db_xref="CDD:434263" Region 415..712 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(421..424,427,429,442,444,517,533..536,579,583..584, 586,596..597) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270798" CDS 1..717 /gene="STE11" /locus_tag="YLR362W" /coded_by="NM_001182251.1:1..2154" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004709 MAP kinase kinase kinase activity [PMID:8159759]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9755161]" /experiment="EXISTENCE:direct assay:GO:0032093 SAM domain binding [PMID:16337230]" /experiment="EXISTENCE:direct assay:GO:0071507 pheromone response MAPK cascade [PMID:8159759]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:10880465]" /experiment="EXISTENCE:genetic interaction:GO:0007232 osmosensory signaling pathway via Sho1 osmosensor [PMID:9180081]" /experiment="EXISTENCE:genetic interaction:GO:0038066 p38MAPK cascade [PMID:9180081]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:9180081]" /experiment="EXISTENCE:genetic interaction:GO:0071507 pheromone response MAPK cascade [PMID:8455599]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8455599]" /experiment="EXISTENCE:mutant phenotype:GO:0001402 signal transduction involved in filamentous growth [PMID:8259520]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:8001818]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:8259520]" /experiment="EXISTENCE:mutant phenotype:GO:0038066 p38MAPK cascade [PMID:9180081]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:9180081]" /experiment="EXISTENCE:mutant phenotype:GO:0071507 pheromone response MAPK cascade [PMID:8159759]" /note="Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851076" /db_xref="SGD:S000004354" ORIGIN 1 meqtqtaegt dlligdektn dlpfvqlfle eigctqylds fiqcnlvtee eikyldkdil 61 ialgvnkigd rlkilrksks fqrdkrieqv nrlknlmekv sslstatlsm nselipekhc 121 vifilndgsa kkvnvngcfn adsikkrlir rlphellatn sngevtkmvq dydvfvldyt 181 knvlhllydv elvtichand rveknrlifv skdqtpsdka istskklylr tlsalsqvgp 241 sssnllaqnk gishnnaegk lridntekdr irqifnqrpp sefistnlag yfphtdmkrl 301 qktmresfrh sarlsiaqrr plsaesnnig dillkhsnav dmallqgldq trlsskldtt 361 kipklahkrp edndaisnql ellsvesgee edhdffgeds divslptkia tpknwlkgac 421 igsgsfgsvy lgmnahtgel mavkqveikn nnigvptdnn kqansdenne qeeqqekied 481 vgavshpktn qnihrkmvda lqhemnllke lhhenivtyy gasqeggnln ifleyvpggs 541 vssmlnnygp feeslitnft rqiligvayl hkkniihrdi kganilidik gcvkitdfgi 601 skklsplnkk qnkraslqgs vfwmspevvk qtattakadi wstgcvviem ftgkhpfpdf 661 sqmqaifkig tnttpeipsw atsegknflr kafeldyqyr psalellqhp wldahii // LOCUS NP_013467 218 aa linear PLN 30-JUN-2025 DEFINITION Nmd4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013467 VERSION NP_013467.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182252.3 REFERENCE 1 (residues 1 to 218) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 218) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 218) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 218) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09667. On Jul 30, 2012 this sequence version replaced NP_013467.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..218 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..218 /product="Nmd4p" /calculated_mol_wt="25155" Region 7..155 /region_name="PIN_ScNmd4p-like" /note="VapC-like PIN domain of Saccharomyces cerevisiae Nmd4p and related proteins; cd18717" /db_xref="CDD:350284" CDS 1..218 /gene="NMD4" /locus_tag="YLR363C" /coded_by="NM_001182252.3:1..657" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:physical interaction:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:7883168]" /note="Protein that may be involved in nonsense-mediated mRNA decay; interacts with Nam7p, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:851077" /db_xref="SGD:S000004355" ORIGIN 1 mtqynfiida safekglgni krwcsdctea vtlnfyiptf tlneldflqq rrksfaares 61 lkfidrldds kfanlkvfie fpevldiilw sdvmehndss gkiniaklpk rlknllksci 121 ykcylegneg lhwflisedp qiremamqcn ipscsivdvd silskdmndk sfresekfnn 181 mmlkngtkee sengreiirt nfnktvyasr gtgelwsp // LOCUS NP_076903 85 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR363W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_076903 VERSION NP_076903.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184486.1 REFERENCE 1 (residues 1 to 85) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 85) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 85) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 85) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09668. Method: conceptual translation. FEATURES Location/Qualifiers source 1..85 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..85 /product="uncharacterized protein" /calculated_mol_wt="9607" Region 1..74 /region_name="DUF2462" /note="Protein of unknown function (DUF2462); pfam09495" /db_xref="CDD:462817" CDS 1..85 /locus_tag="YLR363W-A" /coded_by="NM_001184486.1:1..258" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; relocalizes from nucleus to nucleolus upon DNA replication stress" /db_xref="GeneID:851078" /db_xref="SGD:S000007620" ORIGIN 1 mpqkplkvtk kakdprrvtk kqknlrkaap lqlkskkksl qhlkklkkss sltetterlv 61 askvghlell rgtrkelekg kknsk // LOCUS NP_013468 109 aa linear PLN 30-JUN-2025 DEFINITION glutathione-disulfide reductase GRX8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013468 VERSION NP_013468.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182253.3 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09669. On Jul 30, 2012 this sequence version replaced NP_013468.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..109 /product="glutathione-disulfide reductase GRX8" /calculated_mol_wt="12388" Region 21..84 /region_name="GrxC" /note="Glutaredoxin [Posttranslational modification, protein turnover, chaperones]; COG0695" /db_xref="CDD:440459" CDS 1..109 /gene="GRX8" /locus_tag="YLR364W" /coded_by="NM_001182253.3:1..330" /experiment="EXISTENCE:direct assay:GO:0004362 glutathione-disulfide reductase (NADPH) activity [PMID:19166312]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic" /db_xref="GeneID:851079" /db_xref="SGD:S000004356" ORIGIN 1 msafvtkaee mikshpyfql saswcpdcvy ansiwnklnv qdkvfvfdig slprneqekw 61 riafqkvvgs rnlptivvng kfwgtesqlh rfeakgtlee eltkigllp // LOCUS NP_001335802 110 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR365W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335802 VERSION NP_001335802.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348862.1 REFERENCE 1 (residues 1 to 110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 110) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80322. Method: conceptual translation. FEATURES Location/Qualifiers source 1..110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..110 /product="uncharacterized protein" /calculated_mol_wt="12558" CDS 1..110 /locus_tag="YLR365W" /coded_by="NM_001348862.1:1..333" /note="hypothetical protein; conserved among S. cerevisiae strains; YLR365W is not an essential gene" /db_xref="GeneID:851080" /db_xref="SGD:S000004357" ORIGIN 1 mvkgrhskrk gnfhiilrna sllqrqkldk srstgslles rrqpcvllsf aklfllcivf 61 spkldytkkk tkilklhqsf gtatiltifh lhgsrsvaaq nfilfhdylh // LOCUS NP_013471 130 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS8 RPS22B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013471 VERSION NP_013471.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182256.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09670. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..130 /product="40S ribosomal protein uS8 RPS22B" /calculated_mol_wt="14495" Region 1..130 /region_name="PTZ00158" /note="40S ribosomal protein S15A; Provisional" /db_xref="CDD:185487" CDS 1..130 /gene="RPS22B" /locus_tag="YLR367W" /coded_by="NM_001182256.1:1..393" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication" /db_xref="GeneID:851082" /db_xref="SGD:S000004359" ORIGIN 1 mtrssvlada lnainnaekt gkrqvllrps skviikflqv mqkhgyigef eyiddhrsgk 61 ivvqlngrln kcgvisprfn vkigdiekwt anllparqfg yvilttsagi mdheearrkh 121 vsgkilgfvy // LOCUS NP_013472 598 aa linear PLN 30-JUN-2025 DEFINITION SCF ubiquitin ligase complex subunit MDM30 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013472 VERSION NP_013472.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182257.3 REFERENCE 1 (residues 1 to 598) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 598) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 598) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 598) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09671. On Jul 30, 2012 this sequence version replaced NP_013472.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..598 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..598 /product="SCF ubiquitin ligase complex subunit MDM30" /calculated_mol_wt="70398" Region 15..59 /region_name="F-box_ScMDM30-like" /note="F-box domain found in Saccharomyces cerevisiae mitochondrial distribution and morphology protein 30 (ScMDM30) and similar proteins; cd22143" /db_xref="CDD:438915" Site order(19,23,26..27,30..31,35,37..38,42..44,46) /site_type="other" /note="putative Skp1 binding site [polypeptide binding]" /db_xref="CDD:438915" CDS 1..598 /gene="MDM30" /locus_tag="YLR368W" /gene_synonym="DSG1" /coded_by="NM_001182257.3:1..1797" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /experiment="EXISTENCE:direct assay:GO:0051603 proteolysis involved in protein catabolic process [PMID:16735578]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:18353967]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:18353967]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266]" /experiment="EXISTENCE:mutant phenotype:GO:0008053 mitochondrial fusion [PMID:16790496|PMID:12808031]" /experiment="EXISTENCE:mutant phenotype:GO:0010793 regulation of mRNA export from nucleus [PMID:19376128]" /experiment="EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:18353967]" /experiment="EXISTENCE:mutant phenotype:GO:0051603 proteolysis involved in protein catabolic process [PMID:16735578]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:18353967|PMID:14747994]" /experiment="EXISTENCE:physical interaction:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:18353967]" /note="F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains" /db_xref="GeneID:851083" /db_xref="SGD:S000004360" ORIGIN 1 mtkrrnlfmv gssftidhlp peiwlciskl vgtsdlhnlc linrrlylti tsdeiwkrrc 61 ydrwinresl diltgndyds ipvsqwysyy lrrakwenki fcllwgltee tnpqhfreky 121 lhilqfrhyk latflhriik qgyipdkrpl dlityanyll knvrhkyvfp lfyptnaael 181 knlnnmasrd aemiylrlsa idtsfddlld arefilngic sdllqkykki eeflklrpvt 241 rvsklisist dyldcftqph dsvgqtndra tgrelhredf mllrvysreg rgyktiilai 301 iqaitkrynv dsylardhlv vsepdfpdgr afvtvnedfq pyifdkedll svwsnnfhna 361 enfestvlpa llepisiqhl lteffrellr ckprpfegyp nrahglrdmf pygkvevprd 421 vtmyfafiyd lfdgmfesgm tslrgqmlrd llnyvnannf gdlniiigqn alkepndcws 481 nkrdyvlldd nnkigyfytd ietedtlcal nqyevdgkvf ittidilgdi rvrlaegltp 541 fqgdndklwe sfssvvprtd wglffkgydk errrmqlnpy ieeklsnlan deqplhnl // LOCUS NP_013473 657 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family ATPase SSQ1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013473 VERSION NP_013473.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182258.1 REFERENCE 1 (residues 1 to 657) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 657) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 657) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 657) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09672. Method: conceptual translation. FEATURES Location/Qualifiers source 1..657 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..657 /product="Hsp70 family ATPase SSQ1" /EC_number="3.6.4.10" /calculated_mol_wt="72234" Region 29..656 /region_name="ASKHA_ATPase-like" /note="ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; cl49607" /db_xref="CDD:483947" CDS 1..657 /gene="SSQ1" /locus_tag="YLR369W" /gene_synonym="SSC2; SSH1" /coded_by="NM_001182258.1:1..1974" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8707841]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12756240]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:11601843]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:11273703]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9660806]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:9813017|PMID:11171977]" /experiment="EXISTENCE:mutant phenotype:GO:0044571 [2Fe-2S] cluster assembly [PMID:11273703]" /note="Mitochondrial hsp70-type molecular chaperone; required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis; involved in maturation of Grx5p and Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia" /db_xref="GeneID:851084" /db_xref="SGD:S000004361" ORIGIN 1 mlksgrlnfl klninsrlly stnpqltkkv igidlgttns avayirdsnd kksatiiend 61 egqrttpsiv afdvksspqn kdqmktlvgm aakrqnains entffatkrl igrafndkev 121 qrdmavmpyk ivkcesngqa ylstsngliq spsqiasill kylkqtseey lgekvnlavi 181 tvpayfndsq rqatkdagkl aglnvlrvin eptaaalsfg iddkrnngli avydlgggtf 241 disildiedg vfevratngd thlggedfdn vivnyiidtf ihenpeitre eitknretmq 301 rlkdvserak idlshvkktf ielpfvyksk hlrvpmteee ldnmtlslin rtippvkqal 361 kdadiepedi devilvggmt rmpkirsvvk dlfgkspnss vnpdetvalg aaiqggilsg 421 eiknvllldv tpltlgietf ggafsplipr nttvpvkkte ifstgvdgqa gvdikvfqge 481 rglvrnnkli gdlkltgitp lpkgipqiyv tfdidadgii nvsaaekssg kqqsitvipn 541 sglseeeiak lieeananra qdnlirqrle liskadimis dtenlfkrye klissekeys 601 nivedikalr qaiknfkane ndmsidvngi kkatdalqgr alklfqsatk nqqnqgk // LOCUS NP_013474 178 aa linear PLN 30-JUN-2025 DEFINITION Arc18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013474 VERSION NP_013474.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182259.3 REFERENCE 1 (residues 1 to 178) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 178) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 178) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 178) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09673. On Jul 30, 2012 this sequence version replaced NP_013474.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..178 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..178 /product="Arc18p" /calculated_mol_wt="20447" Region 1..178 /region_name="P21-Arc" /note="ARP2/3 complex ARPC3 (21 kDa) subunit; pfam04062" /db_xref="CDD:461152" CDS 1..178 /gene="ARC18" /locus_tag="YLR370C" /coded_by="NM_001182259.3:1..537" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16107558]" /experiment="EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0051654 establishment of mitochondrion localization [PMID:16107558]" /note="Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches" /db_xref="GeneID:851085" /db_xref="SGD:S000004362" ORIGIN 1 mpayhstfpv dpntdrmvgn fallplntkf rgpaypsnsd ydiidecldl fransffknf 61 eikspadrvl iygilfindc lahlkittsf neavkvltnv aldnftlpgt pgfplnnvyq 121 vpvqdhnsmd llktyiqqfr qelamrller vysstdskey pskfwlaftr rrfmnksl // LOCUS NP_013475 1356 aa linear PLN 30-JUN-2025 DEFINITION Rho family guanine nucleotide exchange factor ROM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013475 VERSION NP_013475.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182260.1 REFERENCE 1 (residues 1 to 1356) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1356) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1356) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1356) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09674. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1356 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1356 /product="Rho family guanine nucleotide exchange factor ROM2" /calculated_mol_wt="152466" Region 4..1356 /region_name="ROM1" /note="RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]; COG5422" /db_xref="CDD:227709" CDS 1..1356 /gene="ROM2" /locus_tag="YLR371W" /coded_by="NM_001182260.1:1..4071" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9348527]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8641285]" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:12015967]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:9348527]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9348527]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:9545237]" /experiment="EXISTENCE:genetic interaction:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:16763112]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:9348527]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:14593073]" /experiment="EXISTENCE:physical interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8641285]" /experiment="EXISTENCE:physical interaction:GO:0007264 small GTPase-mediated signal transduction [PMID:8641285]" /note="Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p; ROM2 has a paralog, ROM1, that arose from the whole genome duplication" /db_xref="GeneID:851086" /db_xref="SGD:S000004363" ORIGIN 1 msetnvdslg drndiysqif gverrpdsfa tfdsdshgdi ssqllpnrie niqnlnvlls 61 ediandiiia kqrrrsgvea aiddsdipnn emkgkssnyi lsqqtnikev pdtqslssad 121 ntpvsspkka rdatsshpiv haksmshiys tsnsasrqak hyndhplppm sprnevyqkn 181 ksttafvpkr kpslpqlala glkkqssfst gsasttptqa rksplqgfgf fsrpsskdlh 241 eqhqhhqhiq hnninnhnnn ntnnngahyq vgssnsnypq hshsissrsm slnsstlkni 301 assfqsktsn srkatqkydi tsnpfsdphh hhhhhhssns hsslnnvhgs gnsssvmgss 361 sniglglktr vsstslalkr ytsvsgtsls sprrssmtpl sasrpvmsas skkpqvypal 421 lsrvatkfks siqlgehkkd glvyrdaftg qqavdvicai irtsdrnlal lfgrsldaqk 481 lfhdvvyehr lrdsphevye ftdnsrftgt gstnahdplm llpnsssfns gnhsypnsgm 541 vpssstssln sdqatltgsr lhmssslsqq knpaaihnvn gvftllaecy sptctrdalc 601 ysiscprrle qqarlnlkpn gglkrnisma lddddeekps wtssvskedw enlpkkeikr 661 qeaiyevyit eknfvkslei trdtfmktla etniisadir knfikhvfah indiysvnrr 721 flkaltdrqr sspvvrgigd ivlrfipffe pfvsyvasrp yakylietqr svnpyfarfd 781 ddmmssslrh gidsflsqgv srpgrymllv keimkstdpe kdksdyedls kamdalrdfm 841 kridqasgaa qdrhdvkllk qkilfkneyv nlglnderrk ikhegilsrk elsksdgtvv 901 gdiqfylldn mllflkakav nkwhqhkvfq rpiplpllfa cpgedmpalr kyigdhpdcs 961 gtviqpeynt snpknaitfl yygakqryqv tlyaaqyagl qtllekikqg qaaiisktem 1021 fnvtkmsdrf fdytnkinsv tscdggrkll iatnsglyms nikrqqnkdh rhkssaffst 1081 piqlvqrnni tqiavleefk siillidkkl yscplsliea egngtsffkk hhkelinhvs 1141 ffaegdcngk rlivtahsss hsikyfeheh pllaekngsg sgnkkslkkk itevifdsep 1201 vsisflkanl cigckkgfqi vsisqnahes lldpadtsle falrdtlkpm aiyrvgnmfl 1261 lcytefaffv nnqgwrkkes hiihwegepq kfaiwypyil afdsnfieir kietgelirc 1321 vladkirllq tstqeilycy edyrgydtva sldfwg // LOCUS NP_013476 345 aa linear PLN 30-JUN-2025 DEFINITION fatty acid elongase ELO3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013476 VERSION NP_013476.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182261.3 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09675. On Jul 30, 2012 this sequence version replaced NP_013476.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..345 /product="fatty acid elongase ELO3" /EC_number="2.3.1.199" /calculated_mol_wt="39334" Region 88..307 /region_name="ELO" /note="GNS1/SUR4 family; pfam01151" /db_xref="CDD:460083" CDS 1..345 /gene="ELO3" /locus_tag="YLR372W" /gene_synonym="APA1; SRE1; SUR4; VBM1" /coded_by="NM_001182261.3:1..1038" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12087109]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:23325927]" /experiment="EXISTENCE:mutant phenotype:GO:0006633 fatty acid biosynthetic process [PMID:9211877]" /experiment="EXISTENCE:mutant phenotype:GO:0006892 post-Golgi vesicle-mediated transport [PMID:9832547]" /experiment="EXISTENCE:mutant phenotype:GO:0009922 fatty acid elongase activity [PMID:12684876]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:9211877]" /experiment="EXISTENCE:mutant phenotype:GO:0030497 fatty acid elongation [PMID:9211877]" /experiment="EXISTENCE:mutant phenotype:GO:0042761 very long-chain fatty acid biosynthetic process [PMID:23325927]" /note="Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7" /db_xref="GeneID:851087" /db_xref="SGD:S000004364" ORIGIN 1 mntttstvia avadqfqsln sssscflkvh vpsienpfgi elwpifskvf eyfsgypaeq 61 fefihnktfl angyhavsii ivyyiiifgg qailralnas plkfkllfei hnlfltsisl 121 vlwllmleql vpmvyhnglf wsicskeafa pklvtlyyln yltkfvelid tvflvlrrkk 181 llflhtyhhg atallcytql igrtsvewvv illnlgvhvi mywyyflssc girvwwkqwv 241 trfqiiqfli dlvfvyfaty tfyahkyldg ilpnkgtcyg tqaaaaygyl iltsylllfi 301 sfyiqsykkg gkktvkkese vsgsvasgss tgvktsntkv ssrka // LOCUS NP_013477 901 aa linear PLN 30-JUN-2025 DEFINITION Vid22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013477 VERSION NP_013477.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182262.1 REFERENCE 1 (residues 1 to 901) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 901) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 901) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 901) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09676. Method: conceptual translation. FEATURES Location/Qualifiers source 1..901 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..901 /product="Vid22p" /calculated_mol_wt="102369" CDS 1..901 /gene="VID22" /locus_tag="YLR373C" /coded_by="NM_001182262.1:1..2706" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26443863|PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11861771]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:34871443]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:23222485]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:23222485]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:23222485]" /experiment="EXISTENCE:mutant phenotype:GO:0007039 protein catabolic process in the vacuole [PMID:11861771]" /note="G-quadruplex (G4) DNA binding protein; maintains genome integrity by promoting the stability of G4-DNA regions; involved in nucleosome displacement during double-strand break repair; involved in fructose-1,6-bisphosphatase (FBPase) transport from the cytosol to Vid (vacuole import and degradation) vesicles during degradation; glycosylated integral membrane protein of the plasma membrane; localizes to the nucleus; contains a BED-type zinc finger domain and a RNase H-like domain" /db_xref="GeneID:851088" /db_xref="SGD:S000004365" ORIGIN 1 mramdtqvqs aerglvlppm nstvssataa ttatntdtdt dgdrdeeres laedgsewvp 61 aymltrdrsr ylghflgvdk mleavkckyc gviirrqgns ismaeasqth lwsthkidpn 121 anyysgwtgv eagstfmvrp plknhqggsa ttnsianlle idedflkrtr ekemalplvq 181 slaiiiasen lplsfvdnta vrllinqnan slsfidhdli lnairsiayn ldriiqrtal 241 rnnsdlslii dknyllmdpt drsnqlsnrl knqlfemqki nffslshsvw nntisilsiq 301 yyddfhsqvk tlpliiqnlh eynndpklsi paqllkisqe lpglqntvis itlprsqivd 361 llnvmdsqpf fpntytnakn yyhnciisii nsailplfgt pksadithpr qssfskeplt 421 lldslidlsn idisnsifsr insflddlqs nswqldkfrs lcekfgfefv cskfdlsrys 481 tatvslqtfl nlrpiieeyq ssiqiekfne idfqiidyll itlnsinril kfftssksln 541 ftyvlfaims iekhllstlg slqfqrliap fetflskiqe fktilfsddm nllamflcpa 601 ilferevley sfhtislsei vdklstsifs llkrflnlht ignvnnshnt snhsnmniht 661 dnqtnninnr sgnnsdnndn ehdndndnhs nsntpasrid idptggensv lpeqqpqnsn 721 nnlsfgslsd thhlsdstis keidsiflqi iqedlydyls tvnsivpisy rsyceqsnfi 781 rdsgrfkkri itedsiigel eqpmnfieel ldihvpvcna fwsqyldnda gpiirilfki 841 mqcqssssir geysflndfi prvhpdltqe iikiklfndq fvaskvdydl dtlqtasqyl 901 p // LOCUS NP_013479 343 aa linear PLN 30-JUN-2025 DEFINITION Stp3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013479 VERSION NP_013479.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182264.3 REFERENCE 1 (residues 1 to 343) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 343) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 343) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 343) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09677. On Jul 30, 2012 this sequence version replaced NP_013479.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..343 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..343 /product="Stp3p" /calculated_mol_wt="37587" Region <137..295 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 144..161 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 171..191 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..343 /gene="STP3" /locus_tag="YLR375W" /coded_by="NM_001182264.3:1..1032" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Zinc-finger hypothetical protein; possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids; STP3 has a paralog, STP4, that arose from the whole genome duplication" /db_xref="GeneID:851089" /db_xref="SGD:S000004367" ORIGIN 1 msnannsamn hitlppissf dnlikaaerq yngeassast hptlpnmnis ngsgsagass 61 smlsyqllph sndvsrsnss ssflpsvqqp tegsasaset sssaspsrsi spilkvagps 121 svggagvstp hstkinkprk kkqcpicrnf yanltthkat hltpedrphk cpichrgfar 181 nndllrhkkr hwkdeilsqs gvlsnhndgk ggsvspnddd thekmtpmns vtdyaqlksl 241 hqikgtfkcp fnstliqldm dmypyklkpl nfetsnchqt gvfsrcdtfk nhlkalhfey 301 ppgtkkkdrn vvpgrckhcg lkfenvdvwl nehvgkqcgy kyh // LOCUS NP_013480 242 aa linear PLN 30-JUN-2025 DEFINITION Psy3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013480 VERSION NP_013480.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182265.1 REFERENCE 1 (residues 1 to 242) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 242) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 242) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 242) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09678. Method: conceptual translation. FEATURES Location/Qualifiers source 1..242 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..242 /product="Psy3p" /calculated_mol_wt="28120" Region 2..226 /region_name="Psy3" /note="Shu complex subunit Psy3; cd19480" /db_xref="CDD:410888" Site order(51..52,76..78,93,95,98,140,180,184,187..189) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:410888" CDS 1..242 /gene="PSY3" /locus_tag="YLR376C" /coded_by="NM_001182265.1:1..729" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15654096|PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0097196 Shu complex [PMID:23575680]" /experiment="EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:15654096]" /experiment="EXISTENCE:genetic interaction:GO:0070987 error-free translesion synthesis [PMID:19496932]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:23575680]" /experiment="EXISTENCE:mutant phenotype:GO:0000730 DNA recombinase assembly [PMID:23575680]" /experiment="EXISTENCE:mutant phenotype:GO:0035861 site of double-strand break [PMID:23575680]" /experiment="EXISTENCE:physical interaction:GO:0097196 Shu complex [PMID:15654096]" /note="Component of Shu complex (aka PCSS complex); Shu complex also includes Shu1, Csm2, Shu2, and promotes error-free DNA repair; promotes Rad51p filament assembly; Shu complex mediates inhibition of Srs2p function; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C" /db_xref="GeneID:851091" /db_xref="SGD:S000004368" ORIGIN 1 mevlkniriy plsnfitstk nyinlpnelr nliseeqesk lgflhiiesd fkpsvalqkl 61 vncttgdeki liidivsiws qqkqrqhgai ymnslscini tglivflell ydspmdalrr 121 cqvdnfnfql rgividnlsf lnfesdknyd vinlskfekl fkilrklref lgcwiitksf 181 ptdfyngien tlvdkwsikr ksgvtlyptk lpdsymkgmd liiyrevvdg rpqyrriaal 241 ee // LOCUS NP_013481 348 aa linear PLN 30-JUN-2025 DEFINITION fructose 1,6-bisphosphate 1-phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013481 VERSION NP_013481.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182266.3 REFERENCE 1 (residues 1 to 348) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 348) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 348) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 348) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09679. On Jul 30, 2012 this sequence version replaced NP_013481.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..348 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..348 /product="fructose 1,6-bisphosphate 1-phosphatase" /EC_number="3.1.3.11" /calculated_mol_wt="38132" Region 27..344 /region_name="FBPase" /note="Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; cd00354" /db_xref="CDD:238214" Site order(27,30,38,40..42,122..123,150) /site_type="other" /note="AMP binding site [chemical binding]" /db_xref="CDD:238214" Site order(85,108..109,128,130,292) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:238214" Site order(131,133..134,225,255..256,260,276,286) /site_type="active" /db_xref="CDD:238214" CDS 1..348 /gene="FBP1" /locus_tag="YLR377C" /gene_synonym="ACN8" /coded_by="NM_001182266.3:1..1047" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12686616|PMID:196563]" /experiment="EXISTENCE:direct assay:GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity [PMID:6304022]" /experiment="EXISTENCE:direct assay:GO:0042597 periplasmic space [PMID:22833678]" /experiment="EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:6321183]" /experiment="EXISTENCE:mutant phenotype:GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity [PMID:2841162]" /experiment="EXISTENCE:mutant phenotype:GO:0072593 reactive oxygen species metabolic process [PMID:16199065]" /note="Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p" /db_xref="GeneID:851092" /db_xref="SGD:S000004369" ORIGIN 1 mptlvngprr dstegfdtdi itlprfiieh qkqfknatgd ftlvlnalqf afkfvshtir 61 raelvnlvgl agasnftgdq qkkldvlgde ifinamrasg iikvlvseeq edlivfptnt 121 gsyavccdpi dgssnldagv svgtiasifr llpdssgtin dvlrcgkemv aacyamygss 181 thlvltlgdg vdgftldtnl gefilthpnl rippqkaiys inegntlywn etirtfiekv 241 kqpqadnnnk pfsaryvgsm vadvhrtfly gglfaypcdk kspngklrll yeafpmaflm 301 eqaggkavnd rgerildlvp shihdkssiw lgssgeidkf ldhigksq // LOCUS NP_013482 480 aa linear PLN 30-JUN-2025 DEFINITION translocon subunit SEC61 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013482 VERSION NP_013482.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182267.1 REFERENCE 1 (residues 1 to 480) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 480) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 480) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 480) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09680. Method: conceptual translation. FEATURES Location/Qualifiers source 1..480 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..480 /product="translocon subunit SEC61" /calculated_mol_wt="52806" Region 1..466 /region_name="PTZ00219" /note="Sec61 alpha subunit; Provisional" /db_xref="CDD:185519" CDS 1..480 /gene="SEC61" /locus_tag="YLR378C" /coded_by="NM_001182267.1:1..1443" /experiment="EXISTENCE:direct assay:GO:0005048 signal sequence binding [PMID:12134063]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005784 Sec61 translocon complex [PMID:8612571|PMID:9252322]" /experiment="EXISTENCE:direct assay:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:11076036]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9252322]" /experiment="EXISTENCE:direct assay:GO:0015450 protein-transporting ATPase activity [PMID:9252322]" /experiment="EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:9252322|PMID:7758110]" /experiment="EXISTENCE:mutant phenotype:GO:0015450 protein-transporting ATPase activity [PMID:1550957]" /experiment="EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:10635318|PMID:9303298]" /experiment="EXISTENCE:mutant phenotype:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:9843581|PMID:32513868]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:24314051]" /experiment="EXISTENCE:mutant phenotype:GO:0070843 misfolded protein transport [PMID:24314051]" /experiment="EXISTENCE:mutant phenotype:GO:1904680 peptide transmembrane transporter activity [PMID:10758167]" /experiment="EXISTENCE:physical interaction:GO:0036503 ERAD pathway [PMID:19696741]" /note="Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex is required for SRP-independent protein translocation into the ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER" /db_xref="GeneID:851095" /db_xref="SGD:S000004370" ORIGIN 1 mssnrvldlf kpfesflpev iaperkvpyn qkliwtgvsl liflilgqip lygivssets 61 dplywlraml asnrgtllel gvspiitssm ifqflqgtql lqirpeskqd relfqiaqkv 121 caiililgqa lvvvmtgnyg apsdlglpic lllifqlmfa slivmlldel lskgyglgsg 181 islftatnia eqifwrafap ttvnsgrgke fegaviaffh llavrkdkkr alveafyrtn 241 lpnmfqvlmt vaiflfvlyl qgfryelpir stkvrgqigi ypiklfytsn tpimlqsalt 301 sniflisqil fqkyptnpli rligvwgirp gtqgpqmals glayyiqplm slsealldpi 361 ktivyitfvl gscavfsktw ieisgtsprd iakqfkdqgm vingkretsi yrelkkiipt 421 aaafggatig alsvgsdllg tlgsgasilm atttiygyye aaakeggftk nlvpgfsdlm // LOCUS NP_001381968 90 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR379W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381968 VERSION NP_001381968.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395038.1 REFERENCE 1 (residues 1 to 90) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 90) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 90) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 90) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54809. Method: conceptual translation. FEATURES Location/Qualifiers source 1..90 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..90 /product="uncharacterized protein" /calculated_mol_wt="10250" CDS 1..90 /locus_tag="YLR379W-A" /coded_by="NM_001395038.1:1..273" /note="Novel ORF identified via pan-genome analysis; conserved in other strains of S. cerevisiae" /db_xref="GeneID:65052912" /db_xref="SGD:S000303812" ORIGIN 1 mlvvwqklpk ermrendken erehvkrkiw saaapgnkce ererckedey iqyilayskl 61 sagsiaysgi tatrvkinmv tndgfgstvl // LOCUS NP_013484 408 aa linear PLN 30-JUN-2025 DEFINITION Csr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013484 VERSION NP_013484.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182269.3 REFERENCE 1 (residues 1 to 408) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 408) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 408) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 408) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09681. On Jul 30, 2012 this sequence version replaced NP_013484.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..408 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..408 /product="Csr1p" /calculated_mol_wt="47332" Region 82..130 /region_name="CRAL_TRIO_N" /note="CRAL/TRIO, N-terminal domain; pfam03765" /db_xref="CDD:461043" Region 168..311 /region_name="CRAL_TRIO" /note="CRAL/TRIO domain; pfam00650" /db_xref="CDD:459890" CDS 1..408 /gene="CSR1" /locus_tag="YLR380W" /gene_synonym="SFH2" /coded_by="NM_001182269.3:1..1227" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:10848624|PMID:12869188]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:17803462]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:12869188]" /experiment="EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10848624|PMID:31690622]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0045717 negative regulation of fatty acid biosynthetic process [PMID:17803462]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16126894]" /experiment="EXISTENCE:genetic interaction:GO:0043001 Golgi to plasma membrane protein transport [PMID:10848624]" /experiment="EXISTENCE:genetic interaction:GO:0045717 negative regulation of fatty acid biosynthetic process [PMID:17803462]" /experiment="EXISTENCE:genetic interaction:GO:0046488 phosphatidylinositol metabolic process [PMID:16262726]" /experiment="EXISTENCE:genetic interaction:GO:1901352 negative regulation of phosphatidylglycerol biosynthetic process [PMID:12869188]" /experiment="EXISTENCE:genetic interaction:GO:2001247 positive regulation of phosphatidylcholine biosynthetic process [PMID:12869188]" /experiment="EXISTENCE:mutant phenotype:GO:0045717 negative regulation of fatty acid biosynthetic process [PMID:17803462]" /note="Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851096" /db_xref="SGD:S000004372" ORIGIN 1 msfdrqlted qevvlkqiwt hlfhlwqvpv dgthifpnns lhssstpakk kksswfsklq 61 ssdhtqdsse aaeaahlyek gkihkalanl dpqttkkqfw hdiknetpda tilkfirark 121 wnadktiaml ghdlywrkdt inkiingger avyennetgv iknlelqkat iqgydndmrp 181 vilvrprlhh ssdqteqele kfsllvieqs klffkenypa sttilfdlng fsmsnmdyap 241 vkflitcfea hypeslghll ihkapwifnp iwniiknwld pvvaskivft knidelhkfi 301 qpqyiprylg gendndldhy tppdgsldvh lkdtetrami ekereelveq fltvtaqwie 361 hqplndpayi qlqekrvqls talcenyskl dpyirsrsvy dyngslkv // LOCUS NP_013485 733 aa linear PLN 30-JUN-2025 DEFINITION Ctf3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013485 VERSION NP_013485.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182270.1 REFERENCE 1 (residues 1 to 733) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 733) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 733) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 733) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09682. Method: conceptual translation. FEATURES Location/Qualifiers source 1..733 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..733 /product="Ctf3p" /calculated_mol_wt="84121" Region 5..240 /region_name="CTF3_NTD_HEAT" /note="N-terminal HEAT repeat domain of inner kinetochore subunit CTF3 and similar proteins; cd22647" /db_xref="CDD:439352" Site order(79,83,87,125,128,131,134..135,138,141..144,164..166, 170,173,176..181,203) /site_type="other" /note="pentamer interface [polypeptide binding]" /db_xref="CDD:439352" CDS 1..733 /gene="CTF3" /locus_tag="YLR381W" /gene_synonym="CHL3" /coded_by="NM_001182270.1:1..2202" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11782448]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:20980819]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11782448]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:22426531]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /note="Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6" /db_xref="GeneID:851097" /db_xref="SGD:S000004373" ORIGIN 1 mslilddiil sltnanertp pqalkttlsl lyekskqygl sspqlqalvr llcetsiidt 61 vtkvyivenc flpdgyltke llleiinhlg tptvfsryri qtppvlqsal ckwlvhvyfl 121 fpvhserehn isssiwlhlw qfsflqkwit plviwqattp vdvkpwklsi ikrcamhpgy 181 rdapgsatli lqrfqclvga ssqitesiit incnrktlks hrnlkldahf lsilkrilsr 241 ahpanfpadt vqntidmyls eihqlgadsi yplrlqslpe yvpsdstvsl wdvtsleqla 301 qnwpqlhipn dvdymmkpsl nsnvllprkv msrdslkhly ssiiliknsr dessspyewc 361 iwqlkrcfah qietpqevip iiisvssmdn klssriiqtf cnlkylklde ltlkkvcggi 421 lplwkpelis gtreffvkfm asifmwstrd ghdnnctfse tcfyvlqmit nwvlddklia 481 lgltllhdmq slltldkifn natsnrfstm afissldilt qlskqtksdy aiqylivgpd 541 imnkvfssdd plllsaacry lvatknklmq ypstnkfvrm qnqyimdltn ylyrnkvlss 601 kslfgvspdf fkqilenlyi ptadfknakf ftitgipals yiciiilrrl etaentkikf 661 tsgiineetf nnffrvhhde igqhgwikgv nnihdlrvki lmhlsntanp yrdiaaflft 721 ylkslskysv qns // LOCUS NP_013486 894 aa linear PLN 30-JUN-2025 DEFINITION leucine--tRNA ligase NAM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013486 VERSION NP_013486.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182271.3 REFERENCE 1 (residues 1 to 894) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 894) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 894) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 894) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09683. On Jul 30, 2012 this sequence version replaced NP_013486.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..894 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..894 /product="leucine--tRNA ligase NAM2" /EC_number="6.1.1.4" /calculated_mol_wt="101790" Region 21..893 /region_name="leuS_bact" /note="leucyl-tRNA synthetase, eubacterial and mitochondrial family; TIGR00396" /db_xref="CDD:273057" Site order(55,57,63,66,94,102,557,559..560,564,597,600,647,649) /site_type="active" /db_xref="CDD:173906" Site 63..66 /site_type="other" /note="HIGH motif" /db_xref="CDD:173906" Site 646..650 /site_type="other" /note="KMSKS motif" /db_xref="CDD:173906" CDS 1..894 /gene="NAM2" /locus_tag="YLR382C" /gene_synonym="MSL1" /coded_by="NM_001182271.3:1..2685" /experiment="EXISTENCE:direct assay:GO:0004823 leucine-tRNA ligase activity [PMID:1990003]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:1990003|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006429 leucyl-tRNA aminoacylation [PMID:1990003]" /experiment="EXISTENCE:genetic interaction:GO:0032543 mitochondrial translation [PMID:16777356]" /experiment="EXISTENCE:mutant phenotype:GO:0000372 Group I intron splicing [PMID:12486008|PMID:2277640]" /experiment="EXISTENCE:physical interaction:GO:0097157 pre-mRNA intronic binding [PMID:11142386]" /note="Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; human homolog LARS2 can complement yeast null mutant, and is implicated in Perrault syndrome" /db_xref="GeneID:851098" /db_xref="SGD:S000004374" ORIGIN 1 mlsrpssrfl stkrgpgpav kkliaigekw kqkttrglpk qdtlnsgsky ilcqfpypsg 61 alhighlrvy visdslnrfy kqkgynvihp mgwdafglpa enaaiersin paiwtrdnia 121 kmkqqmqsml anfdwdreit tcdpeyykft qwiflklfen glayrkeaei nwdpvdmtvl 181 aneqvdaqgr swrsgaivek kqlkqwflgi tkfapklkkh lnqlkdwpsn vkqmqknwig 241 esvgaelvfk vadpkfenli vfttrpetlf avqyvalald hpivqkycee mpdlkefiqk 301 sdqlpndtke gfqlpnikav npltkeevpi faapyvvssy gsapsavmgc pghdnrdfef 361 wqtncpgehi ktciapffdd askvteqerq riidtvpfts tdgvltkecg ehsgvltvva 421 rksimgmlns eglsksvvry kirdwlisrq rywgtpipii hcdncgpvpv pesdlpvklp 481 elegldtkgn plstidefvn vacpscgspa kretdtmdtf idsswyyfrf ldpkntskpf 541 dreiasknmp vdiyiggveh ailhllysrf iakflgsina wsdpagifep fkklvtqgmv 601 qgktyvdpds gkflkpdelt fvndspdgnt viiksngkvp vvsyekmsks kyngadpnec 661 ilrhgpdatr ahilfqspia dalnwdeski vgierwlqkv lhltknilsl ekdlaiskdy 721 ktptdlndae vkfhndfqrf lksitesfev nlslntvisd ymkltniles alkkgevrne 781 mivqnlqklv tviypavpsi seeaaemins qmewnqyrwp evertteskf kkfqivvngr 841 vkfmytadkn flklgrdavi etlmnlpegr mylmnkkikk fvmkfnvisf lfhk // LOCUS NP_013487 1114 aa linear PLN 30-JUN-2025 DEFINITION DNA repair protein SMC6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013487 VERSION NP_013487.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182272.1 REFERENCE 1 (residues 1 to 1114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1114) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09684. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1114 /product="DNA repair protein SMC6" /calculated_mol_wt="127878" Region 82..>237 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Region 107..953 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Site 109..116 /site_type="other" /note="Walker A/P-loop" /db_xref="CDD:213179" Site 221..224 /site_type="other" /note="Q-loop/lid" /db_xref="CDD:213179" Region <1006..1108 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site 1019..1028 /site_type="other" /note="ABC transporter signature motif" /db_xref="CDD:213179" Site 1043..1048 /site_type="other" /note="Walker B" /db_xref="CDD:213179" Site 1051..1054 /site_type="other" /note="D-loop" /db_xref="CDD:213179" Site 1078..1084 /site_type="other" /note="H-loop/switch region" /db_xref="CDD:213179" CDS 1..1114 /gene="SMC6" /locus_tag="YLR383W" /gene_synonym="RHC18" /coded_by="NM_001182272.1:1..3345" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:16793545]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11927594]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:11927594]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0035861 site of double-strand break [PMID:16892052]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:16892052]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391]" /experiment="EXISTENCE:mutant phenotype:GO:0051304 chromosome separation [PMID:15793567]" /experiment="EXISTENCE:mutant phenotype:GO:0071139 resolution of DNA recombination intermediates [PMID:20159973]" /experiment="EXISTENCE:mutant phenotype:GO:1990683 DNA double-strand break attachment to nuclear envelope [PMID:27056668]" /note="Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18" /db_xref="GeneID:851099" /db_xref="SGD:S000004375" ORIGIN 1 misttisgkr pieqvddell sltaqqenee qqqqrkrrrh qfapmtqfns ntldedsgfr 61 sssdvatadq dnfleespsg yikkvilrnf mchehfelel gsrlnfivgn ngsgksailt 121 aitiglgaka setnrgsslk dliregcysa kiilhldnsk ygayqqgifg neiiveriik 181 rdgpasfslr sengkeisnk kkdiqtvvdy fsvpvsnpmc flsqdaarsf ltastsqdky 241 shfmkgtllq eitenllyas aihdsaqenm alhlenlksl kaeyedakkl lrelnqtsdl 301 nerkmllqak slwidvahnt dacknlenei sgiqqkvdev tekirnrqek ierytsdgtt 361 ieaqidakvi yvnekdsehq narellrdvk srfekeksnq aeaqsnidqg rkkvdalnkt 421 iahleeeltk emggdkdqmr qeleqlekan eklrevnnsl vvslqdvkne erdiqheres 481 elrtisrsiq nkkvelqnia kgndtflmnf drnmdrllrt ieqrknefet paigplgslv 541 tirkgfekwt rsiqraisss lnafvvsnpk dnrlfrdimr scgirsnipi vtyclsqfdy 601 skgrahgnyp tivdalefsk peieclfvdl srierivlie dknearnflq rnpvnvnmal 661 slrdrrsgfq lsggyrldtv tyqdkirlkv nsssdngtqy lkdlieqetk elqnirdrye 721 eklsevrsrl keidgrlkst knemrktnfr mtelkmnvgk vvdtgilnsk inerknqeqa 781 iasyeaakee lglkieqiaq eaqpikeqyd stklalveaq delqqlkedi nsrqskiqky 841 kddtiyyedk kkvylenikk ievnvaalke giqrqiqnac afcskerien vdlpdtqeei 901 kreldkvsrm iqkaekslgl sqeevialfe kcrnkykegq kkymeideal nrlhnslkar 961 dqnyknaekg tcfdadmdfr aslkvrkfsg nlsfikdtks leiyilttnd ekarnvdtls 1021 ggeksfsqma lllatwkpmr sriialdefd vfmdqvnrki gttlivkklk diartqtiii 1081 tpqdigkiad idssgvsihr mrdperqnns nfyn // LOCUS NP_013488 1349 aa linear PLN 30-JUN-2025 DEFINITION Elongator subunit IKI3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013488 VERSION NP_013488.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182273.3 REFERENCE 1 (residues 1 to 1349) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1349) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1349) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1349) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09685. On Jul 30, 2012 this sequence version replaced NP_013488.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1349 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1349 /product="Elongator subunit IKI3" /calculated_mol_wt="152860" Region 18..1348 /region_name="COG5290" /note="IkappaB kinase complex, IKAP component [Transcription]" /db_xref="CDD:227610" Region 1004..1034 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 1039..1063 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..1349 /gene="IKI3" /locus_tag="YLR384C" /gene_synonym="ELP1; KTI7; TOT1" /coded_by="NM_001182273.3:1..4050" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:24750273]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0033588 elongator holoenzyme complex [PMID:11689709]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11689709]" /note="Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)" /db_xref="GeneID:851100" /db_xref="SGD:S000004376" ORIGIN 1 mvehdksgsk rqelrsnmrn litlnkgkfk ptastaegde ddlsftllds vfdtlsdsit 61 cvlgstdiga ievqqfmkdg srnvlasfni qtfddkllsf vhfadinqlv fvfeqgdiit 121 atydpvsldp aetlieimgt idngiaaaqw sydeetlamv tkdrnvvvls klfepiseyh 181 levddlkisk hvtvgwgkke tqfrgkgara merealaslk asglvgnqlr dptmpymvdt 241 gdvtaldshe itiswrgdcd yfavssveev pdeddetksi krrafrvfsr egqldsasep 301 vtgmehqlsw kpqgsliasi qrktdlgeed svdviffern glrhgefdtr lpldekvesv 361 cwnsnseala vvlanriqlw tsknyhwylk qelyasdisy vkwhpekdft lmfsdagfin 421 ivdfaykmaq gptlepfdng tslvvdgrtv nitplalanv pppmyyrdfe tpgnvldvac 481 sfsneiyaai nkdvlifaav psieemkkgk hpsivcefpk seftsevdsl rqvafindsi 541 vgvlldtdnl srialldiqd itqptlitiv evydkivllr sdfdynhlvy etrdgtvcql 601 daegqlmeit kfpqlvrdfr vkrvhntsae dddnwsaess elvafgitnn gklfanqvll 661 asavtsleit dsfllfttaq hnlqfvhlns tdfkplplve egvedervra iergsilvsv 721 ipskssvvlq atrgnletiy primvlaevr knimakryke afivcrthri nldilhdyap 781 elfienlevf inqigrvdyl nlfisclsed dvtktkyket lysgisksfg mepapltemq 841 iymkkkmfdp ktskvnkicd avlnvllsnp eykkkylqti itayasqnpq nlsaalklis 901 elenseekds cvtylcflqd vnvvyksals lydvslallv aqksqmdpre ylpflqelqd 961 neplrrkfli ddylgnyeka lehlseidkd gnvseevidy veshdlykhg lalyrydsek 1021 qnviyniyak hlssnqmytd aavayemlgk lkeamgayqs akrwreamsi avqkfpeeve 1081 svaeelissl tfehryvdaa diqleyldnv keavalycka yrydiaslva ikakkdelle 1141 evvdpglgeg fgiiaellad ckgqinsqlr rlrelrakke enpyafygqe teqaddvsva 1201 psetstqesf ftrytgktgg taktgasrrt aknkrreerk rargkkgtiy eeeylvqsvg 1261 rlierlnqtk pdavrvvegl crrnmreqah qiqknfvevl dllkanvkei ysisekdrer 1321 vnengevyyi peipvpeihd fpkshivdf // LOCUS NP_013489 132 aa linear PLN 30-JUN-2025 DEFINITION Swc7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013489 VERSION NP_013489.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182274.1 REFERENCE 1 (residues 1 to 132) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 132) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 132) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 132) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09686. Method: conceptual translation. FEATURES Location/Qualifiers source 1..132 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..132 /product="Swc7p" /calculated_mol_wt="14989" Region 26..128 /region_name="SWC7" /note="SWR1 chromatin-remodelling complex, sub-unit Swc7; pfam17330" /db_xref="CDD:435869" CDS 1..132 /gene="SWC7" /locus_tag="YLR385C" /gene_synonym="AWS1" /coded_by="NM_001182274.1:1..399" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14690608]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:14690608]" /note="hypothetical protein; component of the Swr1p complex that incorporates Htz1p into chromatin" /db_xref="GeneID:851101" /db_xref="SGD:S000004377" ORIGIN 1 mdcpsnvvll llqlvlqrqq tlahrdksvd lqtllkdpvi dndvlvefkt hklvqlygpq 61 ycrdislrgl ktmvtdifan gipknaqssg ndqpvtvvdl anyyymqrin elqntelpql 121 kealltrleh mi // LOCUS NP_013490 880 aa linear PLN 30-JUN-2025 DEFINITION Vac14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013490 VERSION NP_013490.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182275.3 REFERENCE 1 (residues 1 to 880) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 880) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 880) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 880) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09687. On Jul 30, 2012 this sequence version replaced NP_013490.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..880 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..880 /product="Vac14p" /calculated_mol_wt="99642" Region 59..156 /region_name="Vac14_Fab1_bd" /note="Vacuolar 14 Fab1-binding region; pfam12755" /db_xref="CDD:403838" Region 87..115 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 127..156 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 573..746 /region_name="Vac14_Fig4_bd" /note="Vacuolar protein 14 C-terminal Fig4p binding; pfam11916" /db_xref="CDD:463395" CDS 1..880 /gene="VAC14" /locus_tag="YLR386W" /coded_by="NM_001182275.3:1..2643" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11889142|PMID:23708375|PMID:14528018]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:19037259]" /experiment="EXISTENCE:direct assay:GO:0070772 PAS complex [PMID:19037259]" /experiment="EXISTENCE:genetic interaction:GO:0006661 phosphatidylinositol biosynthetic process [PMID:11889142]" /experiment="EXISTENCE:genetic interaction:GO:0042327 positive regulation of phosphorylation [PMID:11889142|PMID:14528018]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:11889142]" /experiment="EXISTENCE:mutant phenotype:GO:0006661 phosphatidylinositol biosynthetic process [PMID:11889142]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:19037259]" /experiment="EXISTENCE:mutant phenotype:GO:0042327 positive regulation of phosphorylation [PMID:11889142]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:11889142]" /experiment="EXISTENCE:mutant phenotype:GO:1903778 protein localization to vacuolar membrane [PMID:14528018]" /experiment="EXISTENCE:physical interaction:GO:0070772 PAS complex [PMID:19037259]" /note="Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(2) to control endolysosome function; similar to mammalian Vac14p" /db_xref="GeneID:851102" /db_xref="SGD:S000004378" ORIGIN 1 meksiakgls dklyekrkaa aleleklvkq cvlegdydri dkiidelcrd yayalhqpma 61 rnaglmglaa taialgindv grylrnilpp vlacfgdqnd qvrfyacesl yniakiakge 121 ilvyfneifd vlckisadte nsvrgaaell drlikdivae rasnyisivn ngshgllpai 181 ktdpisgdvy qeeyeqdnql afslpkfipl lteriyainp dtrvflvdwl kvllntpgle 241 lisylpsflg glftflgdsh kdvrtvthtl mdsllhevdr isklqteikm krlerlkmle 301 dkynnsstpt kkadgaliae kkktlmtalg glskplsmet ddtklsntne tdderhltsq 361 eqlldseats qeplrdgeey ipgqdinlnf pevitvlvnn lasseaeiql ialhwiqvil 421 sispnvfipf lskilsvllk llsdsdphit eiaqlvngql lslcssyvgk etdgkiaygp 481 ivnsltlqff dsridakiac ldwliliyhk apnqilkhnd smfltllksl snrdsvliek 541 alsllqslcs dsndnylrqf lqdlltlfkr dtklvktran fimrqissrl spervykvis 601 sildnyndtt fvkmmiqils tnlitspems slrnklrtce dgmffnslfk swcpnpvsvi 661 slcfvaenye laytvlqtya nyelklndlv qldiliqlfe spvftrmrlq lleqqkhpfl 721 hkclfgilmi ipqskafetl nrrlnslniw tsqsyvmnny irqrensnfc dsnsdisqrs 781 vsqsklhfqe linhfkavse edeyssdmir ldhgannksl llgsfldgid edkqeivtpi 841 spmneainee mespndnssv ilkdsgslpf nrnvsdklkk // LOCUS NP_013491 432 aa linear PLN 30-JUN-2025 DEFINITION Reh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013491 VERSION NP_013491.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182276.1 REFERENCE 1 (residues 1 to 432) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 432) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 432) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 432) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09688. Method: conceptual translation. FEATURES Location/Qualifiers source 1..432 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..432 /product="Reh1p" /calculated_mol_wt="49559" Region <1..54 /region_name="PTZ00448" /note="hypothetical protein; Provisional" /db_xref="CDD:185627" Region 8..30 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275371" Region 188..282 /region_name="zf-C2H2_2" /note="C2H2 type zinc-finger (2 copies); pfam12756" /db_xref="CDD:463690" CDS 1..432 /gene="REH1" /locus_tag="YLR387C" /coded_by="NM_001182276.1:1..1299" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:19433447]" /note="Cytoplasmic 60S subunit biogenesis factor; associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains" /db_xref="GeneID:851103" /db_xref="SGD:S000004379" ORIGIN 1 msstfftcnc cviqfktsdl qryhmktewh rynlkrrian lppigaeqfa eklqisekeq 61 aenqvdefgf pvlkpvmnqs nalpqkqkkp ikskrgrkvg tnllkrkdrd iakekqnrsv 121 spsgsissql snltvgtent ntdygedtvs eygftsdsny eyatsdeeld iadkpsdken 181 ekititeciy cgkdnkever nvkhmfsehg lfipersyli dlngllefli kmividhncl 241 ccnfhgsgle sirahmaskr hcrlpyetke erqlfapfyd ftyddhsisk nlqndraits 301 klssvygakn deedgevdit lvssendina nyttvsides gleltlptga rlghragqry 361 yrqnlpsqpn pnesrrtita adrrmvsgvt ekqykkgmkk mqqleknain tqirreikrv 421 nfqthyrdel lq // LOCUS NP_013492 56 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS14 RPS29A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013492 VERSION NP_013492.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182277.3 REFERENCE 1 (residues 1 to 56) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 56) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 56) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 56) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 56) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09689. On Jul 30, 2012 this sequence version replaced NP_013492.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..56 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..56 /product="40S ribosomal protein uS14 RPS29A" /calculated_mol_wt="6530" Region 5..56 /region_name="PTZ00218" /note="40S ribosomal protein S29; Provisional" /db_xref="CDD:185518" CDS 1..56 /gene="RPS29A" /locus_tag="YLR388W" /coded_by="NM_001182277.3:1..171" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:6814480|PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943|PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480|PMID:18782943]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29A has a paralog, RPS29B, that arose from the whole genome duplication" /db_xref="GeneID:851104" /db_xref="SGD:S000004380" ORIGIN 1 mahenvwfsh prrygkgsrq crvcsshtgl irkyglnicr qcfrekandi gfnkfr // LOCUS NP_013493 1027 aa linear PLN 30-JUN-2025 DEFINITION metalloendopeptidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013493 VERSION NP_013493.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182278.1 REFERENCE 1 (residues 1 to 1027) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1027) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1027) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1027) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1027) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1027) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1027) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1027) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1027) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09690. On Feb 23, 2004 this sequence version replaced NP_013493.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1027 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1027 /product="metalloendopeptidase" /calculated_mol_wt="117448" Region 66..1000 /region_name="Ptr" /note="Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; COG1025" /db_xref="CDD:440648" CDS 1..1027 /gene="STE23" /locus_tag="YLR389C" /coded_by="NM_001182278.1:1..3084" /experiment="EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:19750477]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:28228553]" /experiment="EXISTENCE:genetic interaction:GO:0034982 mitochondrial protein processing [PMID:28228553]" /experiment="EXISTENCE:genetic interaction:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:7569998]" /note="Metalloprotease; involved in N-terminal processing of pro-a-factor to mature form; expressed in both haploids and diploids; one of two yeast homologs of human insulin-degrading enzyme (hIDE); homolog Axl1p is also involved in processing of pro-a-factor" /db_xref="GeneID:851105" /db_xref="SGD:S000004381" ORIGIN 1 mgvsllasss afvtkplltq lvhlspisln ftvrrfkpft clsryyttnp ynmtsnfktf 61 nldflkpdld ersyrfielp nklkalliqd pkadkaaasl dvnigafedp knlpglahfc 121 ehllfmgsek fpdeneyssy lskhggssna ytasqntnyf fevnhqhlfg aldrfsgffs 181 cplfnkdstd keinavnsen kknlqndiwr iyqldksltn tkhpyhkfst gnietlgtlp 241 kenglnvrde llkfhknfys anlmklcilg redldtlsdw tydlfkdvan ngrevplyae 301 pimqpehlqk iiqvrpvkdl kkleisftvp dmeehweskp prilshligh egsgsllahl 361 kklgwanels agghtvskgn affavdidlt dnglthyrdv ivlifqyiem lknslpqkwi 421 fnelqdisna tfkfkqagsp sstvsslakc lekdyipvsr ilamglltky epdlltqytd 481 alvpensrvt lisrsletds aekwygtayk vvdypadlik nmkspglnpa ltlprpnefv 541 stnfkvdkid gikpldepvl llsddvsklw ykkddrfwqp rgyiylsfkl phthasiins 601 mlstlytqla ndalkdvqyd aacadlrisf nktnqglait asgfneklii lltrflqgvn 661 sfepkkdrfe ilkdktirhl knllyevpys qmsnyynaii nerswstaek lqvfekltfe 721 qlinfiptiy egvyfetlih gnikheeale vdslikslip nnihnlqvsn nrlrsyllpk 781 gktfryetal kdsqnvnsci qhvtqldvys edlsalsglf aqlihepcfd tlrtkeqlgy 841 vvfssslnnh gtaniriliq sehttpylew rinnfyetfg qvlrdmpeed fekhkealcn 901 sllqkfknma eesarytaai ylgdynfthr qkkaklvani tkqqmidfye nyimsenask 961 lilhlksqve nkelneneld takyptgqli edvgafkstl fvapvrqpmk dfeisappkl 1021 nnssese // LOCUS NP_013494 112 aa linear PLN 30-JUN-2025 DEFINITION Ecm19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013494 VERSION NP_013494.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182279.3 REFERENCE 1 (residues 1 to 112) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 112) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 112) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 112) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09691. On Jul 30, 2012 this sequence version replaced NP_013494.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..112 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..112 /product="Ecm19p" /calculated_mol_wt="12384" CDS 1..112 /gene="ECM19" /locus_tag="YLR390W" /coded_by="NM_001182279.3:1..339" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:851106" /db_xref="SGD:S000004382" ORIGIN 1 mdwlknttiv vlfshstdks nkhkkrqvqc nmrkntldmv tigiaclvgv ytgtrffepi 61 vidrlrkdgn lrtdipipey dedgnllkvt pslsstpaap ptpptpptpp qq // LOCUS NP_013495 238 aa linear PLN 30-JUN-2025 DEFINITION Ccw14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013495 VERSION NP_013495.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184303.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09692. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..238 /product="Ccw14p" /calculated_mol_wt="23137" Region 20..84 /region_name="CFEM" /note="eight cysteine-containing domain present in fungal extracellular membrane proteins; smart00747" /db_xref="CDD:128986" CDS 1..238 /gene="CCW14" /locus_tag="YLR390W-A" /gene_synonym="SSR1; YLR391W; YLR391W-A" /coded_by="NM_001184303.1:1..717" /experiment="EXISTENCE:direct assay:GO:0005199 structural constituent of cell wall [PMID:9079899]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460|PMID:9079899|PMID:9301021]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:9079899]" /note="Covalently linked cell wall glycoprotein; present in the inner layer of the cell wall" /db_xref="GeneID:851107" /db_xref="SGD:S000006429" ORIGIN 1 mrattllssv vslallskev latppaclla cvaqvgksss tcdslnqvtc ycehensavk 61 kcldsicpnn dadaaysafk sscseqnasl gdssssasss asssskasss tkassssass 121 stkassssas sstkassssa apssskasst esssssssst kapsseesss tyvssskqas 181 stseahsssa asstvsqetv ssalptstav istfsegsgn vleagksvfi aavaamli // LOCUS NP_013496 518 aa linear PLN 30-JUN-2025 DEFINITION Art10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013496 VERSION NP_013496.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182280.3 REFERENCE 1 (residues 1 to 518) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 518) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 518) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 518) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09693. On Jul 30, 2012 this sequence version replaced NP_013496.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..518 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..518 /product="Art10p" /calculated_mol_wt="59627" Region 6..514 /region_name="ART10-like" /note="Arrestin-related trafficking adapter 10 and similar proteins; cd22952" /db_xref="CDD:438568" CDS 1..518 /gene="ART10" /locus_tag="YLR392C" /coded_by="NM_001182280.3:1..1557" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein that contains 2 PY motifs; ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene" /db_xref="GeneID:851108" /db_xref="SGD:S000004384" ORIGIN 1 mapkisisln ppyngefyss ndqmsgivsl qltkalsirk isvilkgfse tltkidqeym 61 fqqngmmmpg qdnksfhtlm kfeqrvfppd nvwnaldgss kpfkvkpgsy nysfqfdkfp 121 rkpeclknht aktvafvtrs narlpptfns hwqefnkidn ldlyfysfgk viymvqvqle 181 lgkssswfkp fhklireiet fefipepkdl iiepdeddne elnafsnnsr gnsmvtnnef 241 fnssnlkvps kdvkvvngvg yiksdrnfsq ansiliengd irsrpvssvt strqstrlvn 301 gmkvfpstyk mglpdgesnm rievrsrdlk qiyrkdylfr sgsqnfdkvy vvmegniasl 361 skmqitplkl qlnllettty lsqgiangny sslklieidl nqlksnkpll dlneirenfd 421 gsmfecelrl kdhpilrklv fneedyrhrg nrlysfktct ikrtfslqll iewgingirk 481 qsevnidpvq ifcqvrehve aealpryvpp ptytemas // LOCUS NP_013497 279 aa linear PLN 30-JUN-2025 DEFINITION Atp10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013497 VERSION NP_013497.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182281.1 REFERENCE 1 (residues 1 to 279) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 279) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 279) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 279) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09694. Method: conceptual translation. FEATURES Location/Qualifiers source 1..279 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..279 /product="Atp10p" /calculated_mol_wt="31963" Region 25..274 /region_name="ATP-synt_10" /note="ATP10 protein; pfam05176" /db_xref="CDD:398716" CDS 1..279 /gene="ATP10" /locus_tag="YLR393W" /coded_by="NM_001182281.1:1..840" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22842922|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:2141026]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:14998992]" /experiment="EXISTENCE:physical interaction:GO:0005743 mitochondrial inner membrane [PMID:14998992]" /experiment="EXISTENCE:physical interaction:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:14998992]" /experiment="EXISTENCE:physical interaction:GO:0051082 unfolded protein binding [PMID:14998992]" /note="Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase; mitochondrial inner membrane protein; interacts genetically with ATP6" /db_xref="GeneID:851109" /db_xref="SGD:S000004385" ORIGIN 1 mqgtfkrfyh ptltrmsfld kflkpmmata spkeyqikql vkpigltqap rkstkysqgn 61 slrdmfdsek tnhrvkelav efsksglydv qvfqktkgkl fiapvsywke dkalffphli 121 gtamdgtkqq niedmlrgkt sivrlfstas gdklsssyfq givddnkktd ylteadarls 181 lndsnvqiie vnlvenavks alvktlarwa nrvpswrqpf yfecsrgqwp fsvreelfcn 241 nvfsgyvflv dqqlkirwaa cgeatpseke alwkfakrl // LOCUS NP_013498 482 aa linear PLN 30-JUN-2025 DEFINITION SUMO ligase CST9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013498 VERSION NP_013498.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182282.3 REFERENCE 1 (residues 1 to 482) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 482) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 482) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 482) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09695. On Jul 30, 2012 this sequence version replaced NP_013498.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..482 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..482 /product="SUMO ligase CST9" /calculated_mol_wt="53732" Region 54..93 /region_name="zf-RING_5" /note="zinc-RING finger domain; pfam14634" /db_xref="CDD:434085" Site order(54,57,72,74,77,88,91) /site_type="other" /note="cross-brace motif" /db_xref="CDD:438111" CDS 1..482 /gene="CST9" /locus_tag="YLR394W" /gene_synonym="ZIP3" /coded_by="NM_001182282.3:1..1449" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:10943844]" /experiment="EXISTENCE:direct assay:GO:0000724 double-strand break repair via homologous recombination [PMID:23593021]" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:19056898|PMID:23593021]" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16782016]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23593021]" /experiment="EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:16847351]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:16847351]" /experiment="EXISTENCE:direct assay:GO:0035861 site of double-strand break [PMID:23593021]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:23593021]" /experiment="EXISTENCE:mutant phenotype:GO:0000775 chromosome, centromeric region [PMID:23593021]" /experiment="EXISTENCE:mutant phenotype:GO:0003682 chromatin binding [PMID:23593021]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:10943844|PMID:15805472]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:16847351|PMID:10943844]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15066280|PMID:23593021]" /experiment="EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:16847351]" /experiment="EXISTENCE:mutant phenotype:GO:0019789 SUMO transferase activity [PMID:16847351]" /experiment="EXISTENCE:mutant phenotype:GO:0035861 site of double-strand break [PMID:23593021]" /note="SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; associates with centromeres early in meiosis, then with chromosome axes and finally with double-strand break sites that are engaged in repair by crossovers; potential Cdc28p substrate" /db_xref="GeneID:851110" /db_xref="SGD:S000004386" ORIGIN 1 mggylaivfi pqtntksmre kkqkclkqvr rlslispkky impdsifeqp fvycgvchrr 61 tshgdplrlt scahilcsqh spltskvcpi crssdisiin lveskqlptd iriffeplpp 121 lleslynvsq fqlnglskqc qyyqnhclkl rekcarqqql lyqakields mailkkriqe 181 lesvlnhnnv ssmsvgvlpt rnshqnhyqp pptvdltvdd nsleefeaks fikklkknss 241 lrnssknnng tvtpstsgrv nknqplfmet lnnpnrnsip ppgmnpnans nlpnistiae 301 stnlnrfsfs pvrvakgfdg klpnldiltn ngsvssknis rlssaslqps splssssnrl 361 ilpnsnlkel hhsntpltst stqfpsalek lkitrkrnnt isgsnrithn lsshvrssgl 421 afssssnslq qsklpksnil krsnstqqlt nthlksdnhl pprssntvlg sskknnkfrr 481 ir // LOCUS NP_013499 78 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c oxidase subunit VIII [Saccharomyces cerevisiae S288C]. ACCESSION NP_013499 VERSION NP_013499.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182283.1 REFERENCE 1 (residues 1 to 78) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 78) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 78) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 78) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09696. Method: conceptual translation. FEATURES Location/Qualifiers source 1..78 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..78 /product="cytochrome c oxidase subunit VIII" /calculated_mol_wt="8776" Region 26..74 /region_name="COX7C" /note="Cytochrome c oxidase subunit VIIc; pfam02935" /db_xref="CDD:427065" Site order(30..32,34,36..37,39,42..43,45,56,59..61,64..65,67, 70..71,74) /site_type="other" /note="Subunit VIIc/I interface [polypeptide binding]" /db_xref="CDD:238469" Site order(45,61,65,69) /site_type="other" /note="Subunit VIIc/VIIIb interface [polypeptide binding]" /db_xref="CDD:238469" Site order(70,74) /site_type="other" /note="Subunit VIIc/VIIa interface [polypeptide binding]" /db_xref="CDD:238469" CDS 1..78 /gene="COX8" /locus_tag="YLR395C" /coded_by="NM_001182283.1:1..237" /experiment="EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:7851399|PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0045277 respiratory chain complex IV [PMID:1331058]" /note="Subunit VIII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain" /db_xref="GeneID:851111" /db_xref="SGD:S000004387" ORIGIN 1 mlcqqmirtt akrssnimtr piimkrsvhf kdgvyenipf kvkgrktpya lshfgffaig 61 favpfvacyv qlkksgaf // LOCUS NP_013500 691 aa linear PLN 30-JUN-2025 DEFINITION tethering complex ATP-binding subunit VPS33 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013500 VERSION NP_013500.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182284.3 REFERENCE 1 (residues 1 to 691) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 691) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 691) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 691) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 691) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09697. On Jul 30, 2012 this sequence version replaced NP_013500.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..691 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..691 /product="tethering complex ATP-binding subunit VPS33" /calculated_mol_wt="79141" Region 14..651 /region_name="SEC1" /note="Proteins involved in synaptic transmission and general secretion, Sec1 family [Intracellular trafficking and secretion]; COG5158" /db_xref="CDD:227487" CDS 1..691 /gene="VPS33" /locus_tag="YLR396C" /gene_synonym="CLS14; MET27; PEP14; SLP1; VAM5; VPL25; VPT33" /coded_by="NM_001182284.3:1..2076" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11853670]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:9624182]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:9624182]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9624182]" /experiment="EXISTENCE:direct assay:GO:0033263 CORVET complex [PMID:17488625]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:16601699]" /experiment="EXISTENCE:direct assay:GO:0035542 regulation of SNARE complex assembly [PMID:18385512]" /experiment="EXISTENCE:direct assay:GO:0099022 vesicle tethering [PMID:27307091]" /experiment="EXISTENCE:genetic interaction:GO:0048278 vesicle docking [PMID:9245783]" /experiment="EXISTENCE:genetic interaction:GO:0051469 vesicle fusion with vacuole [PMID:9245783]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:9624182]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:3062374]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:15047864|PMID:2183024]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:15047864]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:2183024]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:physical interaction:GO:0000329 fungal-type vacuole membrane [PMID:10944212]" /experiment="EXISTENCE:physical interaction:GO:0030897 HOPS complex [PMID:10944212]" /note="ATP-binding protein that is a subunit of the HOPS and CORVET complexes; essential for protein sorting, vesicle docking, and fusion at the vacuole; binds to SNARE domains" /db_xref="GeneID:851112" /db_xref="SGD:S000004388" ORIGIN 1 mnrfwntkkf sltnadglca tlneisqnde vlvvqpsvlp vlnslltfqd ltqstpvrki 61 tllddqlsdd lpsalgsvpq mdliflidvr tslrlppqll daaqkhnlss lhiiycrwkp 121 sfqntledte qwqkdgfdln skkthfpnvi esqlkelsne ytlypwdllp fpqidenvll 181 thslynmenv nmyypnlrsl qsatesilvd dmvnslqsli fetnsiitnv vsignlskrc 241 shllkkride hqtendlfik gtlygertnc glemdliile rntdpitpll tqltyagild 301 dlyefnsgik ikekdmnfny kedkiwndlk flnfgsigpq lnklakelqt qydtrhkaes 361 vheikefvds lgslqqrqaf lknhttlssd vlkvveteey gsfnkilele leilmgntln 421 ndiediilel qyqyevdqkk ilrlicllsl cknslrekdy eylrtfmids wgiekcfqle 481 slaelgffts ktgktdlhit tskstrlqke yryisqwfnt vpiedehaad kitnenddfs 541 eatfaysgvv pltmrlvqml ydrsilfhny ssqqpfilsr eprvsqtedl ieqlygdsha 601 ieesiwvpgt itkkinasik snnrrsidgs ngtfhaaedi alvvflggvt mgeiaimkhl 661 qkilgkkgin krfiiiadgl ingtrimnsi s // LOCUS NP_013501 780 aa linear PLN 30-JUN-2025 DEFINITION AAA family ATPase AFG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013501 VERSION NP_013501.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182285.1 REFERENCE 1 (residues 1 to 780) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 780) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 780) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 780) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 780) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 780) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 780) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 780) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 780) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09698. Method: conceptual translation. FEATURES Location/Qualifiers source 1..780 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..780 /product="AAA family ATPase AFG2" /EC_number="3.6.4.10" /calculated_mol_wt="84617" Region 51..773 /region_name="CDC48" /note="AAA family ATPase, CDC48 subfamily; TIGR01243" /db_xref="CDD:273521" CDS 1..780 /gene="AFG2" /locus_tag="YLR397C" /gene_synonym="DRG1" /coded_by="NM_001182285.1:1..2343" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12006565]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17646390]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:9341149]" /experiment="EXISTENCE:mutant phenotype:GO:0030687 preribosome, large subunit precursor [PMID:17646390]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:17646390]" /note="ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; releases Rlp24p from purified pre-60S particles in vitro; target of the ribosomal biosynthesis inhibitor diazaborine; may be involved in degradation of aberrant mRNAs" /db_xref="GeneID:851113" /db_xref="SGD:S000004389" ORIGIN 1 mapkssssgs kkkssassns adakaskfkl paefitrphp skdhgketct ayihpnvlss 61 leinpgsfct vgkigengil viaragdeev hpvnvitlst tirsvgnlil gdrlelkkaq 121 vqppyatkvt vgslqgynil ecmeekviqk llddsgvimp gmifqnlktk agdesidvvi 181 tdasddslpd vsqldlnmdd myggldnlfy lsppfifrkg sthitfsket qanrkynlpe 241 plsyaavggl dkeieslksa ieiplhqptl fssfgvsppr gillhgppgt gktmllrvva 301 ntsnahvlti ngpsivskyl geteaalrdi fnearkyqps iifideidsi apnranddsg 361 evesrvvatl ltlmdgmgaa gkvvviaatn rpnsvdpalr rpgrfdqeve igipdvdarf 421 diltkqfsrm ssdrhvldse aikyiaskth gyvgadltal cresvmktiq rglgtdanid 481 kfslkvtlkd vesamvdirp samreiflem pkvywsdigg qeelktkmke miqlplease 541 tfarlgisap kgvllygppg csktltakal atesginfla vkgpeifnky vgeseraire 601 ifrkarsaap siiffdeida lspdrdgsst saanhvltsl lneidgveel kgvvivaatn 661 rpdeidaall rpgrldrhiy vgppdvnarl eilkkctkkf nteesgvdlh eladrtegys 721 gaevvllcqe aglaaimedl dvakvelrhf ekafkgiarg itpemlsyye efalrsgsss // LOCUS NP_013502 1287 aa linear PLN 30-JUN-2025 DEFINITION SKI complex RNA helicase subunit SKI2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013502 VERSION NP_013502.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182286.3 REFERENCE 1 (residues 1 to 1287) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1287) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1287) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1287) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09699. On Jul 30, 2012 this sequence version replaced NP_013502.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1287 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1287 /product="SKI complex RNA helicase subunit SKI2" /EC_number="3.6.4.13" /calculated_mol_wt="145928" Region 85..216 /region_name="Ski2_N" /note="Ski2 N-terminal region; pfam17911" /db_xref="CDD:465562" Region 327..>857 /region_name="Dob10" /note="Superfamily II RNA helicase [Replication, recombination and repair]; COG4581" /db_xref="CDD:443638" Region 555..>593 /region_name="FoP_duplication" /note="C-terminal duplication domain of Friend of PRMT1; pfam13865" /db_xref="CDD:464005" Region 823..1083 /region_name="rRNA_proc-arch" /note="rRNA-processing arch domain; pfam13234" /db_xref="CDD:463813" Region 1109..1280 /region_name="DSHCT" /note="DSHCT (NUC185) domain; pfam08148" /db_xref="CDD:462374" CDS 1..1287 /gene="SKI2" /locus_tag="YLR398C" /coded_by="NM_001182286.3:1..3864" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0055087 Ski complex [PMID:18042677|PMID:10744028]" /experiment="EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12769863|PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:10611222|PMID:9482746]" /experiment="EXISTENCE:mutant phenotype:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:17660569|PMID:11910110]" /experiment="EXISTENCE:physical interaction:GO:0055087 Ski complex [PMID:18042677]" /note="Ski complex component and putative RNA helicase; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; mutations in the human ortholog, SKIV2L, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome" /db_xref="GeneID:851114" /db_xref="SGD:S000004390" ORIGIN 1 msegfssssi qelyqslkei tnnadvelfe dritkldfes tdepkhandi ikdrflrpsn 61 alpwslldmv qdvphtsspe dcsgkldyke llkvpdpinr tsyqfkrtgl egkisgykee 121 vdlkevanan asnslsitrs inhnqnsvrg staqlpftpg gipmksvktd seqngsstma 181 natkllhkdg qglfdipegm nrgikpmdsp aenedqngqf kelkqlneid neldiriean 241 eaklkeeeks aksiseeime eateettadn addaeidell pigidfgrtk pvsksvpvkk 301 ewahvvdlnh kienfdelip nparswpfel dtfqkeavyh leqgdsvfva ahtsagktvv 361 aeyaiamahr nmtktiytsp ikalsnqkfr dfketfddvn iglitgdvqi npdanclimt 421 teilrsmlyr gadlirdvef vifdevhyvn dqdrgvvwee viimlpqhvk fillsatvpn 481 tyefanwigr tkqkniyvis tpkrpvplei niwakkelip vinqnsefle anfrkhkeil 541 ngesakgaps ktdngrggst arggrggsnt rdgrggrgns trgganrggs rgagaigsnk 601 rkfftqdgps kktwpeivny lrkrellpmv vfvfskkrce eyadwlegin fcnnkeksqi 661 hmfieksitr lkkedrdlpq ilktrsller giavhhggll pivkelieil fskgfikvlf 721 atetfamgln lptrtvifss irkhdgnglr eltpgeftqm agragrrgld stgtvivmay 781 nsplsiatfk evtmgvptrl qsqfrltynm ilnllrieal rveemikysf senaketlqp 841 ehekqikvlq eelqtieyks ceicdndiek flelmlayke atvnlmqemv kspsilhilk 901 egrlvafrdp ndclklgfvf kvslkdavcv imtftkpykl pngepnhliy fpkadgyrrr 961 nfpkfqktdf ymeevpvtai evitkrkfaa plgkvikkdv aalnefnaet nnildgktlk 1021 eainiekqgl kihqilldrt nirdeifklk sikcpnlsqh ivpkfkahvi kkkieelyhl 1081 msdqnlsllp dyekrlavlk dtefidqnhn vllkgrvace insgyelvlt elildnflgs 1141 fepeeivall svfvyegktr eeeppivtpr lakgkqriee iykkmlcvfn thqipltqde 1201 aefldrkrfa mmnvvyewar glsfkeimem speaegtvvr vitwldeicr evktasiiig 1261 nstlhmkmsr aqelikrdiv faaslyl // LOCUS NP_013503 686 aa linear PLN 30-JUN-2025 DEFINITION chromatin-binding protein BDF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013503 VERSION NP_013503.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182287.1 REFERENCE 1 (residues 1 to 686) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 686) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 686) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 686) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09700. Method: conceptual translation. FEATURES Location/Qualifiers source 1..686 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..686 /product="chromatin-binding protein BDF1" /calculated_mol_wt="76847" Region 1..373 /region_name="COG5076" /note="Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]" /db_xref="CDD:227408" Region <339..417 /region_name="Bromodomain" /note="Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; cl02556" /db_xref="CDD:445827" Site order(344,348,354,393,397,403) /site_type="active" /note="acetyllysine binding site [active]" /db_xref="CDD:99922" Region <386..647 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" Region 527..589 /region_name="BET" /note="Bromodomain extra-terminal - transcription regulation; pfam17035" /db_xref="CDD:435704" CDS 1..686 /gene="BDF1" /locus_tag="YLR399C" /coded_by="NM_001182287.1:1..2061" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:34056863|PMID:7791775]" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:19088068]" /experiment="EXISTENCE:direct assay:GO:0001046 core promoter sequence-specific DNA binding [PMID:17526728|PMID:12620225]" /experiment="EXISTENCE:direct assay:GO:0001094 TFIID-class transcription factor complex binding [PMID:10783167]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12620225]" /experiment="EXISTENCE:direct assay:GO:0140006 histone H3 reader activity [PMID:12620224]" /experiment="EXISTENCE:direct assay:GO:0140008 histone H4 reader activity [PMID:34056863]" /experiment="EXISTENCE:genetic interaction:GO:0031452 negative regulation of heterochromatin formation [PMID:16239142]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:7791775]" /experiment="EXISTENCE:mutant phenotype:GO:0009301 snRNA transcription [PMID:7816623]" /experiment="EXISTENCE:mutant phenotype:GO:0031452 negative regulation of heterochromatin formation [PMID:16239142]" /experiment="EXISTENCE:mutant phenotype:GO:0090054 regulation of silent mating-type cassette heterochromatin formation [PMID:12620225]" /experiment="EXISTENCE:mutant phenotype:GO:0140008 histone H4 reader activity [PMID:34056863]" /experiment="EXISTENCE:mutant phenotype:GO:1905168 positive regulation of double-strand break repair via homologous recombination [PMID:34056863]" /experiment="EXISTENCE:physical interaction:GO:0001094 TFIID-class transcription factor complex binding [PMID:10783167]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:14690608]" /note="BET family transcriptional regulator; associates with TFIID, and is involved in transcription initiation at TATA-containing promoters; essential for meiosis and expression of meiosis-specific genes; binds acetylated histone H4 at double-strand break (DSB) sites, and promotes end resection, loading of RPA and Rad51p and ds break repair by homologous recombination; contains two bromodomains that correspond to the C-terminal region of mammalian TAF1; partially redundant with paralog Bdf2p" /db_xref="GeneID:851115" /db_xref="SGD:S000004391" ORIGIN 1 mtditpvqnd vdvngnnvnd dvssnlkrpi dqgdpsngla eeenpannql hlkkarldgd 61 altsspagla engiegatla angengynat gsgaedeqqg lkkeeggqgt kqedldensk 121 qelpmevpke papapppepd mnnlpqnpip khqqkhalla ikavkrlkda rpflqpvdpv 181 kldipfyfny ikrpmdlsti erklnvgaye vpeqitedfn lmvnnsikfn gpnagisqma 241 rniqasfekh mlnmpakdap pviakgrrss aqedapivir raqthngrpk rtihppkskd 301 iypyeskkpk skrlqqamkf cqsvlkelma kkhasynypf lepvdpvsmn lptyfdyvke 361 pmdlgtiakk lndwqyqtme dferdvrlvf kncytfnpdg tivnmmghrl eevfnskwad 421 rpnlddydsd edsrtqgdyd dyeseysesd idetiitnpa iqyleeqlar mkvelqqlkk 481 qelekirker rlargskkrg krskgrsgsk nasskgrrdk knklktvvty dmkriiteri 541 ndlptskler aidiikksmp niseddevel dldtldnhti ltlyntffrq yesssgasng 601 ldgtsgvtrd asslsptsag srkrrskals qeeqsrqiek iknklailds asplsqngsp 661 gqiqsaahng fssssdddvs seseee // LOCUS NP_013505 668 aa linear PLN 30-JUN-2025 DEFINITION tRNA dihydrouridine synthase DUS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013505 VERSION NP_013505.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182289.3 REFERENCE 1 (residues 1 to 668) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 668) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 668) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 668) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09701. On Jul 30, 2012 this sequence version replaced NP_013505.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..668 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..668 /product="tRNA dihydrouridine synthase DUS3" /EC_number="1.3.1.89" /calculated_mol_wt="76465" Region 96..120 /region_name="zf-CCCH_4" /note="CCCH-type zinc finger; pfam18044" /db_xref="CDD:465626" Region 294..552 /region_name="DUS_like_FMN" /note="Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; cd02801" /db_xref="CDD:239200" Site order(298..300,324,354,383,426,457,509,511,534..535) /site_type="other" /note="FMN binding site [chemical binding]" /db_xref="CDD:239200" Site order(354,386..387,426,428,456..457,459..460,510..511,535) /site_type="active" /db_xref="CDD:239200" Site order(386,428,457,459) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239200" Site order(387,426,456,460,510..511) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:239200" CDS 1..668 /gene="DUS3" /locus_tag="YLR401C" /coded_by="NM_001182289.3:1..2007" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:14970222]" /experiment="EXISTENCE:mutant phenotype:GO:0017150 tRNA dihydrouridine synthase activity [PMID:14970222]" /note="Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; modifies pre-tRNAs at U47 of the variable arm; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:851117" /db_xref="SGD:S000004393" ORIGIN 1 meqnaekrsi vgddnstvkr qdtspskgia hikpeyivpl kqnenqkvai ydeemssdrm 61 tnefaggtnk knkngrgkkr gqnknrdnrq vkeqnvlcpr lihgdiskcs fgdncrfvhd 121 inlylstkkp evesnifpsc pvfnslgfcp mgfkcrflss hlnkednili skkeidpdaq 181 tiwsvkgevn hisperkldl ikrrfpftks neileiidsf qqecrdsmkp eeevestpql 241 kkqdpdveqp vapqveqrnk elsehrmkqr evylkykdtr yfaqekkpld lyhkkivspl 301 ttvgnlpyrr lmrklgadvt ysemalavpl iqgtnsewal pkahtsefpg fgvqvacska 361 wqaakaaeal ansvseisei nlnsgcpidl lyrqgsgsal ldnparmirc lnamnyvskd 421 ipitvkirtg tkeghpiaeg lvkrlvnetd vaaitlhgrs rqqrytksad wdyvsqvadt 481 lrsaeadfie teqgkegrds knriqfvgng dvnnfedwyr ylngnenids vmvargalik 541 pwifeevesq qyldktster ldilrdyaqf smehwgtdey gisqcrrffc efmsffhryv 601 pmgicerypv klnerppnwc grdeletlmg stdvndwikl sdlffgktde nfvfvpkhks 661 ssyanrds // LOCUS NP_013507 683 aa linear PLN 30-JUN-2025 DEFINITION zinc-coordinating transcription factor SFP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013507 VERSION NP_013507.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182291.1 REFERENCE 1 (residues 1 to 683) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 683) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 683) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 683) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 683) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09702. Method: conceptual translation. FEATURES Location/Qualifiers source 1..683 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..683 /product="zinc-coordinating transcription factor SFP1" /calculated_mol_wt="74654" Region 43..683 /region_name="SFP1" /note="Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]; COG5189" /db_xref="CDD:227516" Region 600..629 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 661..683 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..683 /gene="SFP1" /locus_tag="YLR403W" /coded_by="NM_001182291.1:1..2052" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:15353587]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15466158|PMID:26928762|PMID:9832520|PMID:15353587]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15353587|PMID:15466158]" /experiment="EXISTENCE:genetic interaction:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15466158]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:15353587]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:15806610|PMID:15466158]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12089449|PMID:9832520]" /experiment="EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15353587|PMID:15466158|PMID:14555489]" /note="Regulates transcription of ribosomal protein and biogenesis genes; regulates response to nutrients and stress, G2/M transitions during mitotic cell cycle and DNA-damage response, and modulates cell size; regulated by TORC1 and Mrs6p; sequence of zinc finger, ChIP localization data, and protein-binding microarray (PBM) data, and computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p at others; can form the [ISP+] prion" /db_xref="GeneID:851119" /db_xref="SGD:S000004395" ORIGIN 1 mdfttmtmas nmatstttta tsahasinss snfnididsn qntpsilinn nsdssngknt 61 dfngvnnihq knimnntnnv hlyspnimdq tlltpqdiak lrresiahsq gmggvswgsi 121 svgswlrdei isrrnsivpa sangaasaaa satttatntl qiqqptkrps vsnppyhrgy 181 sispqiayta ylpnlekqyc kdysccglsl pglhdllrhy eeahistspn ttnmsqipmn 241 sagntsssvr mtnntssany nlqnnmaant knaghktntm qahssnatnn tsinnmhanl 301 qsnmdsnsti rqsqhphhqq niiqqqlqsn svnhtsgavp tpsvmgsata ssttanpnvi 361 sitgapnsgl smanhsqqlh lngnlvdavs tndvflrtsn spsrhvphnk qinsnnnsgi 421 ninnntshns ninmgsknam vnrphtfnny slnktsrnpi qhqsrkidph qtdlsplvlv 481 qdidlsfmdd dilgpsnhns mnsvvnpttg shnyntfhss vhakssqnmv edqdiddidd 541 dddvdddddd dddddtengs ssngksvhnn nykmpqqayi ddparrlyvm dheeqkpfkc 601 pvigcektyk nqnglkyhrl hghqnqklhe npdgtfsvid pdstdsfgdg mgsakdkpyr 661 cevcgkrykn lnglkyhrgh sth // LOCUS NP_013508 285 aa linear PLN 30-JUN-2025 DEFINITION seipin [Saccharomyces cerevisiae S288C]. ACCESSION NP_013508 VERSION NP_013508.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182292.3 REFERENCE 1 (residues 1 to 285) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 285) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 285) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 285) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09703. On Jul 30, 2012 this sequence version replaced NP_013508.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..285 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..285 /product="seipin" /calculated_mol_wt="32459" Region 48..232 /region_name="Seipin_Sei1_like" /note="Saccharomyces cerevisiae Seipin and similar proteins; cd23994" /db_xref="CDD:467828" CDS 1..285 /gene="SEI1" /locus_tag="YLR404W" /gene_synonym="FLD1" /coded_by="NM_001182292.3:1..858" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:31594806|PMID:18093937]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:24434579]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:18250201]" /experiment="EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:39622802]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:32349126]" /experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:18093937|PMID:18250201|PMID:26572621|PMID:25540432]" /experiment="EXISTENCE:mutant phenotype:GO:0046889 positive regulation of lipid biosynthetic process [PMID:32349126]" /experiment="EXISTENCE:mutant phenotype:GO:0055090 acylglycerol homeostasis [PMID:39622802]" /experiment="EXISTENCE:mutant phenotype:GO:0055091 phospholipid homeostasis [PMID:39622802]" /experiment="EXISTENCE:mutant phenotype:GO:0090155 negative regulation of sphingolipid biosynthetic process [PMID:31594806]" /experiment="EXISTENCE:mutant phenotype:GO:0140042 lipid droplet formation [PMID:32349126]" /note="Seipin involved in lipid droplet (LD) assembly; controls lipid particle morphology, number, and size; promotes initiation of LD formation on the ER; ensures that LDs bud from the ER towards the cytosolic side of the membrane; stabilizes ER-LD contact sites in complex with Ldb16p; regulates phosphatidic acid and diacylglycerol homeostasis at the inner nuclear membrane to preserve nuclear envelope integrity; BSCL2, human homolog implicated in congenital lipodystrophy, complements yeast null mutant" /db_xref="GeneID:851120" /db_xref="SGD:S000004396" ORIGIN 1 mkinvsrplq flqwssyivv afliqlliil plsiliyhdf ylrllpadss nvvplntfni 61 lngvqfgtkf fqsiksipvg tdlpqtidng lsqlipmrdn meykldlnlq lycqsktdhl 121 nldnllidvy rgpgpllgap ggsnskdeki fhtsrpivcl altdsmspqe ieqlgpsrld 181 vydeewlnti riedkisles syetisvflk teiaqrnlii hpesgikfrm nfeqglrnlm 241 lrkrflsyii gisifhciic vlffitgcta fifvrkgqek skkhs // LOCUS NP_013509 367 aa linear PLN 30-JUN-2025 DEFINITION tRNA dihydrouridine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013509 VERSION NP_013509.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182293.1 REFERENCE 1 (residues 1 to 367) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 367) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 367) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 367) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09704. Method: conceptual translation. FEATURES Location/Qualifiers source 1..367 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..367 /product="tRNA dihydrouridine synthase" /EC_number="1.3.1.90" /calculated_mol_wt="41566" Region 45..361 /region_name="Dus" /note="Dihydrouridine synthase (Dus); pfam01207" /db_xref="CDD:426126" CDS 1..367 /gene="DUS4" /locus_tag="YLR405W" /coded_by="NM_001182293.1:1..1104" /experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:14970222]" /experiment="EXISTENCE:mutant phenotype:GO:0017150 tRNA dihydrouridine synthase activity [PMID:14970222]" /note="Dihydrouridine synthase; modifies pre-tRNAs at U20a and U20b of the D loop; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p" /db_xref="GeneID:851121" /db_xref="SGD:S000004397" ORIGIN 1 mhtmhipsgd vlipkpklit eetdplhiik trqkthgrpv tiagpmvrys klpfrqlcre 61 ynvdivyspm ilareyvrne harisdlstn nedtplivqv gvnnvadllk fvemvapycd 121 gigincgcpi keqiregigc aliynsdllc smvhavkdky gdklrietki rihealdetv 181 elcrklcdag vdwitihgrt rrtrssqpan ldaikyiien isdknvpvia ngdcfklsdl 241 eritkytgah gvmavrglls npalfagytt cpwgciekfc ywalefgglp fqlaqhhlyc 301 mlenmelkks llkkmmnlkn yislidwfnk tfefkryged gfgmgveipy kanscvqrsa 361 svverqe // LOCUS NP_013510 113 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL31 RPL31B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013510 VERSION NP_013510.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182294.3 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09705. On Jul 30, 2012 this sequence version replaced NP_013510.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..113 /product="60S ribosomal protein eL31 RPL31B" /calculated_mol_wt="12836" Region 6..87 /region_name="Ribosomal_L31e" /note="Ribosomal protein L31e; pfam01198" /db_xref="CDD:460108" CDS 1..113 /gene="RPL31B" /locus_tag="YLR406C" /coded_by="NM_001182294.3:1..342" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:18829863]" /note="Ribosomal 60S subunit protein L31B; associates with karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality; homologous to mammalian ribosomal protein L31, no bacterial homolog; RPL31B has a paralog, RPL31A, that arose from the whole genome duplication" /db_xref="GeneID:851122" /db_xref="SGD:S000004398" ORIGIN 1 maglkdvvtr eytinlhkrl hgvsfkkrap ravkeikkfa klhmgtedvr lapelnqaiw 61 krgvkgveyr lrlrisrkrn eeedaknplf syvepvlvas akglqtvvve eda // LOCUS NP_878135 49 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR406C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878135 VERSION NP_878135.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184610.1 REFERENCE 1 (residues 1 to 49) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 49) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 49) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 49) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09706. Method: conceptual translation. FEATURES Location/Qualifiers source 1..49 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..49 /product="uncharacterized protein" /calculated_mol_wt="5679" CDS 1..49 /locus_tag="YLR406C-A" /coded_by="NM_001184610.1:1..150" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole" /db_xref="GeneID:1466423" /db_xref="SGD:S000028683" ORIGIN 1 miqkpillss flflyirall hsihpyirts vhlytkkits ynflgvpfk // LOCUS NP_013511 228 aa linear PLN 30-JUN-2025 DEFINITION Gag1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013511 VERSION NP_013511.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182295.4 REFERENCE 1 (residues 1 to 228) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 228) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 228) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 228) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09707. On Jul 30, 2012 this sequence version replaced NP_013511.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..228 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..228 /product="Gag1p" /calculated_mol_wt="25415" Region <144..220 /region_name="DUF4050" /note="Protein of unknown function (DUF4050); pfam13259" /db_xref="CDD:463820" CDS 1..228 /gene="GAG1" /locus_tag="YLR407W" /coded_by="NM_001182295.4:1..687" /note="hypothetical protein; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus; Interacts with CKA2 in a potentially competitive mode with the CK2 holoenzyme. Structural prediction analysis reveals a clamp-domain (rear, hinge, front), an unstructured gag region, and a lock-domain" /db_xref="GeneID:851123" /db_xref="SGD:S000004399" ORIGIN 1 mtvstsktpk knikytltht lqkwketlkk ithetlssid dssgsdekie alftvsqpav 61 vaskgidrds gasmsqvggg vnstlemklt deseesssan nttttashtl snskkstqnf 121 enynvveeri klaqkskapf cnaekiwkrr rqlwtqpteq sesanndgvt rreifqaipq 181 eyyarvykkl vvddkplrep lnledalqvi nagwtetrkw anaakgmp // LOCUS NP_013512 122 aa linear PLN 30-JUN-2025 DEFINITION Bls1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013512 VERSION NP_013512.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182296.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09708. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..122 /product="Bls1p" /calculated_mol_wt="14418" CDS 1..122 /gene="BLS1" /locus_tag="YLR408C" /coded_by="NM_001182296.1:1..369" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]" /note="Subunit of the BLOC-1 complex involved in endosomal maturation; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene" /db_xref="GeneID:851124" /db_xref="SGD:S000004400" ORIGIN 1 mfltfsmcvn wiivkmpnrs eeldrlldki insphrteas ktlqeiennq syilnvqlkk 61 llrlhddsfk nkcvspinym lekytpymgh tealqkeael vdrdlrilem tyqlieknrn 121 sk // LOCUS NP_013513 939 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein UTP21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013513 VERSION NP_013513.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182297.3 REFERENCE 1 (residues 1 to 939) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 939) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 939) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 939) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 939) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 939) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 939) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 939) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 939) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09709. On Jul 30, 2012 this sequence version replaced NP_013513.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..939 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..939 /product="rRNA-processing protein UTP21" /calculated_mol_wt="104660" Region 81..377 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(92,96,112..113,130,134,140..141,164,184,191..192,205, 222,227,233..234,246..247,265,270,276..277,290..291,311, 316,324..325,348..349,368,372,376..377) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 167..202 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 210..245 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 251..293 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 284..613 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(291,312,316,324..325,348..349,368,372,378..379,391, 394,432,437,443..444,458,476,481,487..488,500..501,519,523, 529..530,542,559,564,570..571,583..584,602,606,612..613) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 299..348 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 353..408 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 464..500 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 505..541 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 547..582 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 588..624 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 714..937 /region_name="Utp21" /note="Utp21 specific WD40 associated putative domain; pfam04192" /db_xref="CDD:461219" CDS 1..939 /gene="UTP21" /locus_tag="YLR409C" /coded_by="NM_001182297.3:1..2820" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922|PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0034388 Pwp2p-containing subcomplex of 90S preribosome [PMID:15231838|PMID:17515605]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:19150991]" /note="Subunit of U3-containing 90S preribosome and SSU processome complexes; involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma; Small Subunit processome is also known as SSU processome" /db_xref="GeneID:851125" /db_xref="SGD:S000004401" ORIGIN 1 msidlkkrkv eedvrsrgkn skifspfrii gnvsngvpfa tgtlgstfyi vtcvgktfqi 61 ydantlhllf vseketpssi valsahfhyv yaayenkvgi ykrgieehll eletdanveh 121 lcifgdylca stddnsifiy kksdpqdkyp sefytkltvt eiqggeivsl qhlatylnkl 181 tvvtksnvll fnvrtgklvf tsnefpdqit taepapvldi ialgtvtgev imfnmrkgkr 241 irtikipqsr isslsfrtdg sshlsvgtss gdlifydldr rsrihvlkni hresyggvtq 301 atflngqpii vtsggdnslk eyvfdpslsq gsgdvvvqpp rylrsrgghs qppsyiafad 361 sqshfmlsas kdrslwsfsl rkdaqsqems qrlhkkqdgg rvggstiksk fpeivalaie 421 narigeweni itahkdekfa rtwdmrnkrv grwtfdttdd gfvksvamsq cgnfgfigss 481 ngsitiynmq sgilrkkykl hkravtgisl dgmnrkmvsc gldgivgfyd fnkstllgkl 541 kldapitamv yhrssdlfal alddlsivvi davtqrvvrq lwghsnrita fdfspegrwi 601 vsasldstir twdlptggci dgiivdnvat nvkfspngdl latthvtgng iciwtnraqf 661 ktvstrtide sefarmalps tsvrgndsml sgalesngge dlndidfnty tsleqidkel 721 ltlsigprsk mntllhldvi rkrskpkeap kkseklpffl qlsgekvgde asvregiahe 781 tpeeihrrdq eaqkkldaee qmnkfkvtgr lgfeshftkq lregsqskdy ssllatlinf 841 spaavdleir slnsfepfde ivwfidaltq glksnknfel yetfmsllfk ahgdvihann 901 knqdiasalq nwedvhkked rlddlvkfcm gvaafvtta // LOCUS NP_013514 1146 aa linear PLN 30-JUN-2025 DEFINITION inositol polyphosphate kinase VIP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013514 VERSION NP_013514.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182298.1 REFERENCE 1 (residues 1 to 1146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1146) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09710. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1146 /product="inositol polyphosphate kinase VIP1" /EC_number="2.7.4.24" /calculated_mol_wt="129625" Region 189..277 /region_name="PPIP5K2_N" /note="Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain; pfam18086" /db_xref="CDD:465643" Region <264..492 /region_name="LysX" /note="Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; COG0189" /db_xref="CDD:439959" Region 538..1047 /region_name="His_Phos_2" /note="Histidine phosphatase superfamily (branch 2); pfam00328" /db_xref="CDD:395259" CDS 1..1146 /gene="VIP1" /locus_tag="YLR410W" /coded_by="NM_001182298.1:1..3441" /experiment="EXISTENCE:direct assay:GO:0000829 diphosphoinositol pentakisphosphate kinase activity [PMID:17412958]" /experiment="EXISTENCE:direct assay:GO:0000830 inositol hexakisphosphate 4-kinase activity [PMID:17412958]" /experiment="EXISTENCE:direct assay:GO:0000831 inositol hexakisphosphate 6-kinase activity [PMID:17412958]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032958 inositol phosphate biosynthetic process [PMID:17412958]" /experiment="EXISTENCE:direct assay:GO:0052723 inositol hexakisphosphate 1-kinase activity [PMID:18981179]" /experiment="EXISTENCE:direct assay:GO:0052724 inositol hexakisphosphate 3-kinase activity [PMID:18981179]" /experiment="EXISTENCE:direct assay:GO:0052841 inositol bisdiphosphate tetrakisphosphate diphosphatase activity [PMID:39966396]" /experiment="EXISTENCE:direct assay:GO:0052843 inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity [PMID:31436531]" /experiment="EXISTENCE:direct assay:GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [PMID:31436531]" /experiment="EXISTENCE:mutant phenotype:GO:0030643 intracellular phosphate ion homeostasis [PMID:17412959]" /experiment="EXISTENCE:mutant phenotype:GO:0052841 inositol bisdiphosphate tetrakisphosphate diphosphatase activity [PMID:39966396]" /note="Bifunctional inositol pyrophosphate kinase and phosphatase; contains two conserved catalytic motifs, a PPIP5K kinase domain that phosphorylates inositol hexakis- and heptakisphosphate, and a PPIP5K phosphatase domain that preferentially hydrolyzes, 1PP-InsP5 and 1,5-InsP8; unique GAF domain channels PPase substrates to the active site; IP7 levels decrease during starvation, suggesting a role in Pi homeostasis; may regulate the dimorphic switch and function of the cortical actin cytoskeleton" /db_xref="GeneID:851126" /db_xref="SGD:S000004402" ORIGIN 1 msgikkepie sdevpqqetk nnlpsapsem splflnkntq kamqsiapil egfspktsas 61 enmslklppp giqddhseen ltvhdtlqrt istalgngnn tntvttsglk kadsesksea 121 dpeglsnsni vndadninsi sktgsphlpq gtmdaeqtnm gtnsvptssa ssrksstshp 181 kprlpkvgki gvcamdakvl skpmrhilnr liehgefetv ifgdkvilde rienwptcdf 241 lisffssgfp ldkaikyvkl rkpfiindli mqkilwdrrl clqvleaynv ptpprleisr 301 dggpraneel raklrehgve vkpveepewk mvdddtlevd gktmtkpfve kpvdgedhni 361 yiyyhskngg ggrrlfrkvg nkssefdptl vhprtegsyi yeqfmdtdnf edvkaytige 421 nfchaetrks pvvdgivrrn thgkevryit elsdeektia gkvskafsqm icgfdllrvs 481 gksyvidvng fsfvkdnkay ydscanilrs tfieakkkmd mekknlpiir eekeqkwvfk 541 glaiiirhad rtpkqkfkhs ftspifisll kghkeevvir nvndlkivlq alrialdeka 601 gnpakikvla nalekklnfp gtkiqlkpvl nkenevekvq filkwggept hsakyqatel 661 geqmrqdfdl lnksilqnik ifssserrvl htaqywtral fgadelgsde isirkdlldd 721 snaakdlmdk vkkklkpllr egkeappqfa wpskmpepyl vikrvvelmn yhkkimdnnf 781 akkdvnsmqt rwctsedpsl fkerwdklfk efnnaekvdp skiselydtm kydalhnrqf 841 lenifdpglp neaiadelgs hslvdrypin vlaknnfkii dshsmnnsgk nssnsvgslg 901 wvlesgktst arnpksssqf deprfmqlre lyklakvlfd ficpkeygis daekldigll 961 tslplakqil ndigdmknre tpacvayftk eshiytllni iyesgipmri arnalpeldy 1021 lsqitfelye stdasgqksh sirlkmspgc htqdpldvql ddrhyiscip kisltkhldm 1081 dyvqqklrnk ftrvimppkf tpvnitspnl sfqkrktrrk svsveklkrp assgssssts 1141 vnktld // LOCUS NP_058174 1770 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058174 VERSION NP_058174.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184411.4 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09711. On Jul 30, 2012 this sequence version replaced NP_058174.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1770 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="201992" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 574..641 /region_name="gag_pre-integrs" /note="GAG-pre-integrase domain; pfam13976" /db_xref="CDD:372857" Region 660..761 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1285..>1468 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1621..1757 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1625..1628,1662..1664,1667,1700,1727,1754) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1770 /locus_tag="YLR410W-B" /coded_by="join(NM_001184411.4:1..1293, NM_001184411.4:1295..5314)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:851128" /db_xref="SGD:S000007380" ORIGIN 1 mesqqlhqnp hslhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidlknq hseipqaktk vgnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lgqqqkeskp thtidsndel pdhllidsga sqtlvrsahy lhhatpnsei 481 nivdaqkqdi pinaignlhf nfqngtktsi kalhtpniay dllslselan qnitacftrn 541 tlersdgtvl apivkhgdfy wlskkylips hiskltinnv nksksvnkyp yplihrmlgh 601 anfrsiqksl kknavtylke sdiewsnast yqcpdcligk stkhrhvkgs rlkyqesyep 661 fqylhtdifg pvhhlpksap syfisftdek trfqwvyplh drreesilnv ftsilafikn 721 qfnarvlviq mdrgseytnk tlhkfftnrg itacytttad srahgvaerl nrtllndcrt 781 llhcsglpnh lwfsavefst iirnslvspk ndksarqhag lagldittil pfgqpvivnn 841 hnpdskihpr gipgyalhps rnsygyiiyl pslkktvdtt nyvilqdnqs kldqfnydtl 901 tfdddlnrlt ahnqsfieqn eteqsydqnt esdhdyqsei einsdplvnd fssqsmnplq 961 ldhepvqkvr apkevdadis eynilpspvr srtphiinke stemggties dttsprhsst 1021 ftarnqkrpg spndmidlts qdrvnyglen ikttrlggte epyiqrnsdt nikyrttnst 1081 psiddrssns esttpiisie tkavcdntps idtdppeyrs sdhatpnimp dkssknvtad 1141 silddlplpd lthksptdts dvskdiphih srqtnsslgg mddsnvlttt kskkrsledn 1201 eteievsrdt wnnknmrsle pprskkrinl iaaikgvksi kpvrttlryd eaitynkdnk 1261 ekdryveayh keisqllkmn twdtnkyydr ndidpkkvin smfifnkkrd gthkarfvar 1321 gdiqhpdtyd sdmqsntvhh yalmtslsia ldndyyitql dissaylyad ikeelyirpp 1381 phlglndkll rlrkslyglk qsganwyeti ksylinccdm qevrgwscvf knsqvticlf 1441 vddmilfskd lnankkiitt lkkqydtkii nlgerdneiq ydilgleiky qrskymklgm 1501 ekslteklpk lnvplnpkgk klrapgqpgh yidqdeleid edeykekvhe mqkliglasy 1561 vgykfrfdll yyintlaqhi lfpsrqvldm tyeliqfmwd trdkqliwhk nkptkpdnkl 1621 vaisdasygn qpyyksqign ifllngkvig gkstkasltc tstteaeiha vseaipllnn 1681 lshlvqelnk kpiikglltd srstisiiks tneekfrnrf fgtkamrlrd evsgnnlyvy 1741 yietkkniad vmtkplpikt fklltnkwih // LOCUS NP_058175 438 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058175 VERSION NP_058175.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184410.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09712. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..438 /product="gag protein" /calculated_mol_wt="49641" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..438 /locus_tag="YLR410W-A" /coded_by="NM_001184410.1:1..1317" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:851127" /db_xref="SGD:S000007379" ORIGIN 1 mesqqlhqnp hslhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidlknq hseipqaktk vgnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 yadiltvlck svskmqtnnq elkdwialan leydgstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lrpateri // LOCUS NP_013515 241 aa linear PLN 30-JUN-2025 DEFINITION high-affinity Cu transporter CTR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013515 VERSION NP_013515.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182299.3 REFERENCE 1 (residues 1 to 241) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 241) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 241) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 241) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09713. On Jul 30, 2012 this sequence version replaced NP_013515.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..241 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..241 /product="high-affinity Cu transporter CTR3" /calculated_mol_wt="27403" Region 20..210 /region_name="Ctr" /note="Ctr copper transporter family; pfam04145" /db_xref="CDD:461194" CDS 1..241 /gene="CTR3" /locus_tag="YLR411W" /coded_by="NM_001182299.3:1..726" /experiment="EXISTENCE:direct assay:GO:0005375 copper ion transmembrane transporter activity [PMID:10924521]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10924521]" /experiment="EXISTENCE:direct assay:GO:0015677 copper ion import [PMID:10924521]" /note="High-affinity copper transporter of the plasma membrane; acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae" /db_xref="GeneID:851129" /db_xref="SGD:S000004403" ORIGIN 1 mnmggsssta akkatckism lwnwytidtc fiarswrndt kgkfagscig cfalvvvaqw 61 ltrfsrqfdv ellkrqkikh lasyspeeyv vkcgeedaks dieelqgfyn epswkttlis 121 lqksfiysfy vwgprrlnep eddllkkvls cctlitpvdl yptfldhmir vtifvlqwgl 181 syiimllfmy yngyiiiscl igaivgrfif cyeplgslga ngsaqgtvsy dkesddrkcc 241 l // LOCUS NP_013516 274 aa linear PLN 30-JUN-2025 DEFINITION Ber1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013516 VERSION NP_013516.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182300.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09714. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..274 /product="Ber1p" /calculated_mol_wt="31576" Region 40..209 /region_name="SRR1" /note="SRR1 domain; pfam07985" /db_xref="CDD:462330" CDS 1..274 /gene="BER1" /locus_tag="YLR412W" /coded_by="NM_001182300.1:1..825" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0007017 microtubule-based process [PMID:18064466]" /note="Protein involved in microtubule-related processes; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene" /db_xref="GeneID:851130" /db_xref="SGD:S000004404" ORIGIN 1 mdfkasgtkf kktgkkvvpa kafeeivqtn rdvlkksafl sdllenlqph lnnikkircv 61 aignfkedfp atyqfallle itdyiksede rdvvvslydp iftkeeiqyl kslgskwlie 121 eefsendaid yesvlyflph apldltenil ssqrphlwla nnmishtdry tkaklcenyp 181 nlsklvhylq tnappevkka hdvdgfatfi pkrkrknrnn ssklkvtpsd idydsiapkf 241 kscqiltdfd egkylkekpw insfsdltlh aiey // LOCUS NP_878136 68 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR412C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878136 VERSION NP_878136.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184570.3 REFERENCE 1 (residues 1 to 68) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 68) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 68) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 68) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09715. On Jul 30, 2012 this sequence version replaced NP_878136.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..68 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..68 /product="uncharacterized protein" /calculated_mol_wt="7868" CDS 1..68 /locus_tag="YLR412C-A" /coded_by="NM_001184570.3:1..207" /note="hypothetical protein" /db_xref="GeneID:1466424" /db_xref="SGD:S000028572" ORIGIN 1 mhlcqnghyy kphrasaekv pylkkkkkns rnegkakkkn ekkkigtvef fqqkkkekkr 61 vlnavcgl // LOCUS NP_013517 675 aa linear PLN 30-JUN-2025 DEFINITION Ina1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013517 VERSION NP_013517.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182301.1 REFERENCE 1 (residues 1 to 675) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 675) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 675) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 675) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09716. Method: conceptual translation. FEATURES Location/Qualifiers source 1..675 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..675 /product="Ina1p" /calculated_mol_wt="72567" CDS 1..675 /gene="INA1" /locus_tag="YLR413W" /coded_by="NM_001182301.1:1..2028" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:24379413]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; not an essential gene; YLR413W has a paralog, FAT3, that arose from the whole genome duplication" /db_xref="GeneID:851131" /db_xref="SGD:S000004405" ORIGIN 1 mnfkillpic alltlttfll tiiatagsts nykpitniyi gdadiskinv tkvmpqvgpi 61 ltvlgsalta pnttvdtifg alkaiastea lspllhllsn aantsatlss ltqlapmall 121 gtntattttf saldelltts knttelldgf stlmssmstn tsstsaslen tvltllvdst 181 npigttesli tlnnmtteek tklspvfelf assknitatc daletimnst iptstvsslf 241 sslktslaeg gnatetimql gslvpsslkp avqavvtlfd ettsqnvtls vlstmiaeni 301 tqsssakaam galtdllnyt tnqtelltsv eslalskeaa sstnqlvald eilsasanas 361 tvvsiiptle sqlanntvll kyvpylfsll aassdpvssf sslvnitkwa etnaatfmpm 421 lkilnsavnm ttitpeqlke mtpsileylh ipviyrlsif tmcrahlnrt myscskshav 481 qnmdfrsivy nniegsdfkp ymdalnigkd dlhldgelqd rqhmyvpavk aalamnlmci 541 itsfflmvfl lllsrrsvvs qklwlalgfi scwicifsgl gstifsviln mmksgskkdn 601 ydviisgssp fyglmwsgfv favlvflcia ycwwssrkga aiveaekavq esdsttsrii 661 eehespidae knfar // LOCUS NP_013518 263 aa linear PLN 30-JUN-2025 DEFINITION Pun1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013518 VERSION NP_013518.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182302.3 REFERENCE 1 (residues 1 to 263) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 263) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 263) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 263) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 263) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09717. On Jul 30, 2012 this sequence version replaced NP_013518.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..263 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..263 /product="Pun1p" /calculated_mol_wt="29120" Region 6..240 /region_name="SUR7" /note="SUR7/PalI family; pfam06687" /db_xref="CDD:399580" CDS 1..263 /gene="PUN1" /locus_tag="YLR414C" /coded_by="NM_001182302.3:1..792" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18799621]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:21223946]" /note="Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress" /db_xref="GeneID:851132" /db_xref="SGD:S000004406" ORIGIN 1 mrnfftlffa aifslgalil aivacagstk nyspinkiyc aeldlsqmkv stvlpslssa 61 tlsslglpsy iniglwsyct vdsshniqsc ssphgiqnfn lsslvydnin nnealelmds 121 vasvvlpekl kskmtyynnl vkcmfitili givltfvnlv fnvlrwiihi rpltwfgaff 181 sffafaallv sigsclgtys yikyilkhny sdygismsig rnyqglmwga vvgallnfil 241 wcsvrsrptv iyanapieek pli // LOCUS NP_013519 112 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR415C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013519 VERSION NP_013519.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182303.1 REFERENCE 1 (residues 1 to 112) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 112) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 112) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 112) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 112) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09718. Method: conceptual translation. FEATURES Location/Qualifiers source 1..112 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..112 /product="uncharacterized protein" /calculated_mol_wt="12214" CDS 1..112 /locus_tag="YLR415C" /coded_by="NM_001182303.1:1..339" /note="hypothetical protein; YLR415C is not an essential gene" /db_xref="GeneID:851133" /db_xref="SGD:S000004407" ORIGIN 1 mylsaqlmrt vtashltlra lstpplfqhr qiaavewcgt trpglarqkr tqhassvisk 61 sgvlsakpss vflallagkl aekyiyarml lfhvsvvnec pvvfhsgpvv wk // LOCUS NP_013521 566 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-II subunit protein VPS36 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013521 VERSION NP_013521.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182305.3 REFERENCE 1 (residues 1 to 566) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 566) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 566) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 566) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09719. On Jul 30, 2012 this sequence version replaced NP_013521.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..566 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..566 /product="ESCRT-II subunit protein VPS36" /calculated_mol_wt="63887" Region 4..122 /region_name="PH-GRAM-like_Vps36" /note="Pleckstrin homology-like domain or GLUE (GRAM-like ubiquitin-binding in Eap45) domain of Vps36; cd13227" /db_xref="CDD:275409" Site order(38,86,89) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:275409" Region 109..164 /region_name="Vps36-NZF-N" /note="Vacuolar protein sorting 36 NZF-N zinc-finger domain; pfam16988" /db_xref="CDD:407195" Region 118..146 /region_name="RanBP2-type Zn finger" /note="RanBP2-type Zn finger [structural motif]" /db_xref="CDD:275376" Region 179..203 /region_name="ZnF_RBZ" /note="Zinc finger domain; smart00547" /db_xref="CDD:197784" Region 181..200 /region_name="RanBP2-type Zn finger" /note="RanBP2-type Zn finger [structural motif]" /db_xref="CDD:275376" Region 323..548 /region_name="EAP30" /note="EAP30/Vps36 family; pfam04157" /db_xref="CDD:461201" CDS 1..566 /gene="VPS36" /locus_tag="YLR417W" /gene_synonym="GRD12; VAC3; VPL11" /coded_by="NM_001182305.3:1..1701" /experiment="EXISTENCE:direct assay:GO:0000814 ESCRT II complex [PMID:12194858]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:19380877|PMID:15029239]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11278625]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12194858]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:17428789|PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /note="Component of ESCRT-II complex; contains GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into endosome; plays role in lager yeast flocculation under brewing conditions; plays role in formation of mutant huntingtin (Htt) aggregates in yeast" /db_xref="GeneID:851135" /db_xref="SGD:S000004409" ORIGIN 1 meywhyvett ssgqpllreg ekdifidqsv glyhgkskil qrqrgriflt sqriiyidda 61 kptqnslgle lddlayvnys sgfltrsprl ilffkdpssk delgksaeta sadvvstwvc 121 picmvsnetq geftkdtlpt picincgvpa dyeltkssin csnaidpnan pqnqfgvnse 181 nicpactfan hpqignceic ghrlpnaskv rsklnrlnfh dsrvhielek nslarnkssh 241 salssssstg sstefvqlsf rksdgvlfsq ateralenil teknkhifnq nvvsvngvdm 301 rkgassheyn nevpfietkl srigisslek srenqllnnd ilfnnaltdl nklmslatsi 361 erlyknsnit mktktlnlqd estvnepktr rpllildrek flnkelflde iareiyeftl 421 sefkdlnsdt nymiitlvdl yamynksmri gtglispmem reacerfehl glnelklvkv 481 nkrilcvtse kfdvvkeklv dligdnpgsd llrltqilss nnsksnwtlg ilmevlqncv 541 degdllidkq lsgiyyykns ywpshi // LOCUS NP_013522 393 aa linear PLN 30-JUN-2025 DEFINITION Cdc73p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013522 VERSION NP_013522.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182306.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09720. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..393 /product="Cdc73p" /calculated_mol_wt="44325" Region 1..393 /region_name="CDC73" /note="RNA polymerase II assessory factor [Transcription]; COG5157" /db_xref="CDD:227486" CDS 1..393 /gene="CDC73" /locus_tag="YLR418C" /coded_by="NM_001182306.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:11983171]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11983171]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15643076]" /experiment="EXISTENCE:direct assay:GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding [PMID:22796944]" /experiment="EXISTENCE:direct assay:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:20299458]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:11927560]" /experiment="EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:21737840]" /experiment="EXISTENCE:mutant phenotype:GO:0006362 transcription elongation by RNA polymerase I [PMID:19164765]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:15149594]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:14710186]" /experiment="EXISTENCE:mutant phenotype:GO:0045910 negative regulation of DNA recombination [PMID:9891041]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:9032243|PMID:11884586]" /experiment="EXISTENCE:physical interaction:GO:0016593 Cdc73/Paf1 complex [PMID:11927560|PMID:9032243|PMID:11884586]" /note="Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay; role in preventing L-A mycovirus pathogenesis; protein abundance increases in response to DNA replication stress; human homolog, parafibromin, is a tumour suppressor linked to breast, renal and gastric cancers" /db_xref="GeneID:851136" /db_xref="SGD:S000004410" ORIGIN 1 mansldrlre hlkngdklvl knnegqstdd itkatmvetl ssdgstqdsf plneeteiei 61 dgslvqlrii vhcwmnkdss aadyladcqn kqltnvsflq rtdlinwlsg ntessqylka 121 pgqkgetsdk vdienktlag elstvkstts aslendsevs dpvvvetmkh erilvdhnsa 181 lrgakpinfg ylikdaelkl vqsikgslrg sklppghkga hgrisktngs sggprkdpii 241 lipsaassil tvanikqfll eskyvnprnl psvpnglvni eknferisrp irfiivdntr 301 mftkpeywdr vvaifttght wqfnnyqwns pqelfqrckg yyfhfagdsv pqhvqqwnve 361 kveldknkrf kdvevvryfw hslekelisr gyr // LOCUS NP_013523 1435 aa linear PLN 30-JUN-2025 DEFINITION RNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013523 VERSION NP_013523.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182307.3 REFERENCE 1 (residues 1 to 1435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1435) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09721. On Jul 30, 2012 this sequence version replaced NP_013523.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1435 /product="RNA helicase" /EC_number="3.6.4.13" /calculated_mol_wt="162914" Region 369..409 /region_name="UBA_YLR419W_like" /note="UBA domain found in Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and similar proteins; cd14271" /db_xref="CDD:270457" Region 428..532 /region_name="RWD_YLR419W-like" /note="RWD domain of Saccharomyces cerevisiae putative ATP-dependent RNA helicase YLR419W and related proteins; cd23827" /db_xref="CDD:467662" Region 600..>1219 /region_name="HrpA" /note="HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; COG1643" /db_xref="CDD:441249" Region 1205..>1342 /region_name="OB_NTP_bind" /note="Oligonucleotide/oligosaccharide-binding (OB)-fold; pfam07717" /db_xref="CDD:400182" CDS 1..1435 /locus_tag="YLR419W" /coded_by="NM_001182307.3:1..4308" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="Predicted RNA helicase of the DEAH-box family; the authentic, non-tagged protein is detected in highly purified mitochondria in HTP studies and sediments with the 40S ribosomal subunit; crosslinks with 18S rRNA; non-essential gene; contains a ubiquitin-associated domain, an RWD domain, a helicase ATP-binding DEAD-like domain, a helicase C terminal domain and a helicase associated domain; does not contain a Rb-like A/B pocket structure; homolog of mammalian translation initiation factor DHX29" /db_xref="GeneID:851137" /db_xref="SGD:S000004411" ORIGIN 1 makktknnsk sstpvndvpt tagkkkakgk kgqepepedd krakqqsnra kvtstaswtg 61 klphtilhet cqkrkwnkve ydmkkigdkg fiaiavlsft dpktketlta rmndptydka 121 sgkglvipqe tpiearhmas tialyriayn tnlhmmlppn hrktwyaldd frkdnlktde 181 krinklfdld pfktmvedrk lkaqrekeqv aqnnqaqkeq vartilsshg gisssgkdrq 241 erkvashkns hnpslvrfpk kvwensifvd ldessrqlie tslkekidwq akkishknet 301 iaenredlka klltlqfrpk hveeamlykd plsfllfnlp eddlppffhk kkgdtknkve 361 itnlplstrm iverlteigv ssdeallalq qndmneneaa gfltreilpt lnsntnepvs 421 etesiecwnq eleslesiye gcvmdakeds hytlnliekl kiklkvyrtk nypaslpgiv 481 vstfdknykl pdyikkqilt rllhylqegn ligdmlvyhi yewlkenisk iidnpgplip 541 dsdskgaink rnisngkrsi nnsssrkftk ttisedtlsv lreeytkrik sseyksmqlv 601 reqlpawkkq kviidiinkn evvlitgetg sgkstqvvqf ildflqkekg dfgktkivct 661 qprrisaigl aervsdercv tcgeevgyvi rgvnktkast rikfmttgvl vrllqnartm 721 lentivvide vhersidtdl ivtlmknllh rvrgmkivlm satvnvdlfk kffpglatch 781 iegrtfpitd yfledilsdl dfkikrekal sydddsvder nnddqylkpr adskfftsgq 841 inydllcqvv eyvhkrlkaa ndngsiivfl pgvgeinkcc nllanksnea dfmvlplhsa 901 ltpedqkrvf kkyhgkrkvv vstniaetsi tiddcvatid tgraksmfyn pkdnttklie 961 sfiskaevkq rrgragrvre glsyklfskn lyendmismp ipeikriple slylsvkamg 1021 ikdvkaflst aldapplpal qkaeriltti glvdesdksl tqlgqfislm pvmdskhgkl 1081 liygilfgct disvllvsil gigvlpfigg fenrekikkl lckyesrgdl favleivrdy 1141 fkikdssikr kylrdnllsy nkineiksst aqyysilkdv gflpmdykvg sisdlnrner 1201 nfdilrailt gafyphiarv qlpdvkylst ssgavekdpe akmikywirs eeyqdkleey 1261 ktkisqetqk vdledlplpa trafihpssv lfstnsvnle dakllsevdg pisrqskipt 1321 vvkypfvlft tsqvtnklyl rdltptttls lllfggaisy diggtihspg ivvdnwlpir 1381 twckngvlik elrtqldeai rkklespdya kksqidnsga dktlkiveki iaseq // LOCUS NP_013524 364 aa linear PLN 30-JUN-2025 DEFINITION dihydroorotase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013524 VERSION NP_013524.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182308.1 REFERENCE 1 (residues 1 to 364) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 364) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 364) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 364) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09722. Method: conceptual translation. FEATURES Location/Qualifiers source 1..364 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..364 /product="dihydroorotase" /EC_number="3.5.2.3" /calculated_mol_wt="40182" Region 4..360 /region_name="pyrC_dimer" /note="dihydroorotase, homodimeric type; TIGR00856" /db_xref="CDD:129935" Site order(14,16,98,137,180,258) /site_type="active" /db_xref="CDD:238619" Site order(18,229..230,260,262,275..276) /site_type="other" /note="substrate binding pocket [chemical binding]" /db_xref="CDD:238619" Site order(153..156,218..219,228,235,271..273) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238619" CDS 1..364 /gene="URA4" /locus_tag="YLR420W" /coded_by="NM_001182308.1:1..1095" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004151 dihydroorotase activity [PMID:2897615|PMID:4550660]" /experiment="EXISTENCE:mutant phenotype:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:4550660]" /experiment="EXISTENCE:mutant phenotype:GO:0006221 pyrimidine nucleotide biosynthetic process [PMID:2897615]" /note="Dihydroorotase; catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate" /db_xref="GeneID:851139" /db_xref="SGD:S000004412" ORIGIN 1 mvqeidlglt cdmhvhvreg amcelvtpki rdggvsiayi mpnlqppitt ldrvieykkt 61 lqklapkttf lmsfylskdl tpdliheaaq qhairgvkcy pagvttnsaa gvdpndfsaf 121 ypifkamqee nlvlnlhgek psvhdgdkep ihvlnaeeaf lpalkklhnd fpnlkiileh 181 ctsesaikti edinknvkka tdvkvaatlt ahhlfltidd wagnpvnfck pvaklpndkk 241 alvkaavsgk pyfffgsdsa phpvqnkany egvcagvysq sfaipyiaqv feeqnalenl 301 kgfvsdfgis fyevkdseva ssdkailfkk eqvipqvisd gkdisiipfk agdklswsvr 361 wepr // LOCUS NP_013525 156 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle lid subunit RPN13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013525 VERSION NP_013525.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182309.3 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09723. On Jul 30, 2012 this sequence version replaced NP_013525.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..156 /product="proteasome regulatory particle lid subunit RPN13" /calculated_mol_wt="17771" Region 13..103 /region_name="Proteasom_Rpn13" /note="Proteasome complex subunit Rpn13 ubiquitin receptor; pfam04683" /db_xref="CDD:461390" CDS 1..156 /gene="RPN13" /locus_tag="YLR421C" /coded_by="NM_001182309.3:1..471" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:11029046]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:18497817]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11029046|PMID:17499717]" /note="Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:851140" /db_xref="SGD:S000004413" ORIGIN 1 msmsstvikf ragvceyned srlctpipvq geieikpnee eelgfwdfew rptekpvgre 61 ldpislilip getmwvpiks sksgrifalv fssneryffw lqeknsgnlp lnelsakdke 121 iynkmigvln nssesdeees ndekqkaqdv dvsmqd // LOCUS NP_013526 1932 aa linear PLN 30-JUN-2025 DEFINITION guanine nucleotide exchange factor DCK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013526 VERSION NP_013526.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182310.1 REFERENCE 1 (residues 1 to 1932) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1932) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1932) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1932) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1932) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1932) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1932) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1932) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1932) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09724. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1932 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1932 /product="guanine nucleotide exchange factor DCK1" /calculated_mol_wt="221433" Region 1417..1815 /region_name="DHR2_DOCK" /note="Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins; cd11684" /db_xref="CDD:212566" Site order(1500,1511,1513..1514,1516..1517,1520..1521, 1523..1524,1527..1528) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:212566" Site order(1539,1541,1565,1568..1571,1573..1574,1587..1589, 1607..1609,1647..1650,1656..1657,1660,1662,1699..1700,1703, 1729..1730,1732..1733,1736..1738,1741..1743,1746..1747, 1749,1777,1799..1800,1803) /site_type="other" /note="Rac/Cdc42 binding site [polypeptide binding]" /db_xref="CDD:212566" Site order(1741..1743,1746) /site_type="other" /note="nucleotide sensor" /db_xref="CDD:212566" CDS 1..1932 /gene="DCK1" /locus_tag="YLR422W" /coded_by="NM_001182310.1:1..5799" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25598154]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25598154]" /experiment="EXISTENCE:genetic interaction:GO:0035556 intracellular signal transduction [PMID:25598154]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:25598154]" /experiment="EXISTENCE:mutant phenotype:GO:0035556 intracellular signal transduction [PMID:25598154]" /note="Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1; upstream component for regulation through the small GTPase Rho5p; may form a complex with Lmo1p that acts as a GEF for Rho5p; interacts with Ino4p; cytoplasmic protein that relocates to mitochondria under oxidative stress; implicated in mitophagy; not an essential protein; DOCK proteins act as guanine nucleotide exchange factors" /db_xref="GeneID:851141" /db_xref="SGD:S000004414" ORIGIN 1 msqqdsqrwl ptdrliygvl vksflplqry pelvyensny anvyvgaevy vfeesvdkkw 61 crayqclrpf peefisnmns andvlpdvkp kvvifprkyv hfeaekavst mpffkapsae 121 dfkpliskec esrsfcdsly vsstddistg kprktprppf pffryqkrsf kdemgpilsl 181 isshvysmys igefsiyrkm iklyydldti rfrlsmnltt eaekinlira atslrtkiak 241 flsstyrknk lianstprnp dpygfegifa rdidtgells yeidklrtlv sssmlcgltn 301 nfptvpvves ddesssnglf gtvrssilvn lkdlawdpsi sdpkyqdlsi cvylrtkdev 361 ltesftmtks snmesaldei pamlfknile tivhknkvyl vvvlketiai ttetapeiss 421 ynisteesss hspfspfnss tenkidhvkk glaagvinis pvfkfyngls vankaqrfnl 481 ylyssdssds qnfnsskdad lgwgglinki ikdssegvsv npravslsvt vkeiigkqea 541 ekvlstslvp irsiptyfyd tmfsqaeriy lnlgrvslyg lpaadtnien vtvqiscrnk 601 avkfcknkle ersgdwkfvs vrpnesiges iriegvenmn edetlrvlvy lngflmaksn 661 ihikkkneii eyrkgtvfqi mssksvplih leleasyfgr ryninpaitn flvlqtknve 721 fdqqlkehys vtlkqlnnvs fkdllkhfdt ilahylllle svneatdkkg pssslpnivf 781 sefvkflnlm lthqensryw fnrlykkvms kelecpnvap ilikhmttif drshsswtrt 841 gtaicrtily iivlaigssh sdempnfshf frslhkflml adepimadqi lliesipsml 901 etmtnhckve dlvrfaiglf eccqekemnq kmysrplsvr eeeylntkfn cllklinkkv 961 lqnyltntes vdklrlqfls ktlewlltpy tpgddkcfhv eslrlvnsvf itiiedykfd 1021 mlqrnlirll pylcksfvhl rryckkarlm rprrvftmlf preipcnyip vdsivndevv 1081 vevllelaii iceitkiass rfpsyqsfse iinlcdkdtl fqsnfysrqi tnenvytitk 1141 tvflffkqdw fpgmkwlgvs allgrsslil lslckdyiie nnspspskes ekrvdmrlwa 1201 eyvkvillvs nhksasltkl aitprkavyl isgdlkkisa yilnecwdal atghynitya 1261 kkyglgalsd cqfelfvhnq flireififa fhrhidatri cckilwglgl nfwrifgslq 1321 pavnacipel fsayqigklr lndyelerfv sclffmmhvp dsdtffpacm dflrdllgfl 1381 hivneiykip nqeefdddrt arhiemfeyl leanrpelfh kmiydlfihf iqkkdfvqaa 1441 lslellagty awdsndtlea isfpplpeqs sferkeyllk esarnfsrgq kpekalavyk 1501 dlikaydein ydlnglafvh dqiagiytrl qsidrlvpty fkvsfmgfgf pkslrnksfv 1561 feglpfehit smhdrllrsy hgsnivhsqe evdmllmnpp mgkyihvasv epclsisdny 1621 nssdkkssin nkvrmyienr dlrtfsnsrr lpgakgvtdl wveeytyhtm ntfptlmnrs 1681 eivkvtkskl splenairsl qvkiqelygl enmcnktlkd hgdvndlfte lstnitgtis 1741 apvnggisqy kaflepstsk qfstddlgrl tlafdelvav lgrcltlhae llpskdlkps 1801 hdllvrlfee nfaeeierys rtlseanrsr nnmitariis hknpnkkasf sgrdhhtsgs 1861 nhsqfvlehs dsfgpnsllf gkyltrtlsh ssttssldks givsgtsstf lagsqpntnt 1921 dsqhkhdysh sg // LOCUS NP_013527 417 aa linear PLN 30-JUN-2025 DEFINITION protein kinase regulatory subunit ATG17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013527 VERSION NP_013527.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182311.3 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09725. On Jul 30, 2012 this sequence version replaced NP_013527.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..417 /product="protein kinase regulatory subunit ATG17" /calculated_mol_wt="48525" Region 16..392 /region_name="ATG17_like" /note="Autophagy protein ATG17-like domain; pfam04108" /db_xref="CDD:427715" CDS 1..417 /gene="ATG17" /locus_tag="YLR423C" /gene_synonym="APG17" /coded_by="NM_001182311.3:1..1254" /experiment="EXISTENCE:direct assay:GO:0000045 autophagosome assembly [PMID:18725539]" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:15901835]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18725539]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:18725539|PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0034497 protein localization to phagophore assembly site [PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:1990316 Atg1/ULK1 kinase complex [PMID:26753620]" /experiment="EXISTENCE:genetic interaction:GO:0060090 molecular adaptor activity [PMID:17295840]" /experiment="EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:18077553]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:15743910]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:15901835]" /experiment="EXISTENCE:mutant phenotype:GO:0030295 protein kinase activator activity [PMID:10995454]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0045772 positive regulation of autophagosome size [PMID:18077553]" /experiment="EXISTENCE:physical interaction:GO:1990316 Atg1/ULK1 kinase complex [PMID:15743910]" /note="Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhibits autophagy in human cells" /db_xref="GeneID:851142" /db_xref="SGD:S000004415" ORIGIN 1 mneadvtkfv nnarktltda qllcssanlr ivdikkklss wqlsisklnf livglrqqgk 61 flytilkegi gtkliqkqwn qavlvvlvde mkywqyeits kvqrldgivn elsisekddt 121 dpsklgdyis rdnvnllndk lkevpvierq ieniklqyen mvrkvnkeli dtkltdvtqk 181 fqskfgidnl metnvaeqfs reltdlekdl aeimnsltqh fdktlllqdk kidndereel 241 fkvvqgddke lynifktlhe viddvdktil nlgqflqaki kektelhsev seiindfnrn 301 leyllifkdi snlidsfkns ctqdiqttke lcefydnfee sygnlvleak rrkdvanrmk 361 tilkdcekql qnldaqdqee rqnfiaengt ylpetiwpgk iddfsslytl nynvknp // LOCUS NP_013528 708 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SPP382 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013528 VERSION NP_013528.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182312.1 REFERENCE 1 (residues 1 to 708) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 708) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 708) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 708) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 708) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09726. Method: conceptual translation. FEATURES Location/Qualifiers source 1..708 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..708 /product="mRNA splicing protein SPP382" /calculated_mol_wt="82918" Region 61..104 /region_name="G-patch" /note="G-patch domain; pfam01585" /db_xref="CDD:396249" CDS 1..708 /gene="SPP382" /locus_tag="YLR424W" /gene_synonym="CCF8; NTR1" /coded_by="NM_001182312.1:1..2127" /experiment="EXISTENCE:direct assay:GO:0000390 spliceosomal complex disassembly [PMID:16357217|PMID:16880513]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:17875666]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0071008 U2-type post-mRNA release spliceosomal complex [PMID:16357217]" /experiment="EXISTENCE:genetic interaction:GO:0000390 spliceosomal complex disassembly [PMID:17875666]" /experiment="EXISTENCE:mutant phenotype:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:16945917]" /experiment="EXISTENCE:mutant phenotype:GO:0000390 spliceosomal complex disassembly [PMID:16880513]" /experiment="EXISTENCE:mutant phenotype:GO:0071008 U2-type post-mRNA release spliceosomal complex [PMID:16357217]" /note="Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation" /db_xref="GeneID:851143" /db_xref="SGD:S000004416" ORIGIN 1 medsdsntdk kfffkkrrid synysdeedn nssmnsdmty tndalktssg naptiskltk 61 tygigaklls smgyvagkgl gkdgsgittp ietqsrpmhn aglgmfsntn ssnyhsened 121 ylssedevve gieqvkfnkt stevlgeall ndsgdmtivr tlrelrlagv qlpesilkel 181 dplnavpkpk kdvvveilqe llgiekslea irqrtsplev qvkeyygqer llselevtlr 241 deskhvslyd kigailklsd delidrltsc llrkellief dldhlekpnd ildeltqiie 301 llayrmdtts kflnrtqtti fkviypklkk fwegfdmtks kidsaitlll dfqqvlsfig 361 ckehimeefv ypkllqeldn welhdevdhv spriwvldfm vliddkikdt ivdkieakff 421 aycknwyhre sfcitnsdii fikelicerr yykilckefl pkfldelwer hndpiyeled 481 wkekqewkek dsgffyfmkk lrsythyfhp kqyelmmrgt fnninkilyq whlystvedl 541 hkskwwlnwl mntvfehslp teielseirk synifamshr yhldkstlde dfdlrqglrn 601 lmetqviddi sqseqeptyt vqniplgkvs ssfkdvvedy clekgylisk ipnrytqlpy 661 grdqdcivpl feirngkkkm evalkhdilw vedssgtfkp iylwaldl // LOCUS NP_013529 1307 aa linear PLN 30-JUN-2025 DEFINITION Rho family guanine nucleotide exchange factor TUS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013529 VERSION NP_013529.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182313.3 REFERENCE 1 (residues 1 to 1307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1307) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09727. On Jul 30, 2012 this sequence version replaced NP_013529.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1307 /product="Rho family guanine nucleotide exchange factor TUS1" /calculated_mol_wt="148982" Region 469..655 /region_name="RhoGEF" /note="Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cd00160" /db_xref="CDD:238091" Site order(475,479,575,606..607,610..611,613..614,617..618, 621..622,625,651,655) /site_type="other" /note="GTPase interaction site [polypeptide binding]" /db_xref="CDD:238091" Region 939..1287 /region_name="CNH" /note="Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2; smart00036" /db_xref="CDD:214481" CDS 1..1307 /gene="TUS1" /locus_tag="YLR425W" /gene_synonym="SOP10" /coded_by="NM_001182313.3:1..3924" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:18256282]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:11839800]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:16763112]" /experiment="EXISTENCE:genetic interaction:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:16763112]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:11839800]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:11839800]" /experiment="EXISTENCE:mutant phenotype:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:16763112]" /note="Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate" /db_xref="GeneID:851145" /db_xref="SGD:S000004417" ORIGIN 1 myrynrsspf ertpekrvsr qesqrksiel pklpplntrn sflddsdngt dnisigwtpi 61 sdtqqfqspv pqaftftskh sargngtsss estpkstkyv kerrpppppp llystesiri 121 dspmvspssq srerspnkls fignseerhh meyisnhsri lkspfangfs pnspksprds 181 skqqahfsde sdlrcherek alppipfttt lllspfdded sefftkpppp lstsrnvsgn 241 srvsealesv ysdsdytfnn snarqssfns llgakplela psitaptqpf siqsidehkl 301 yqcdnvykls aiyewilkvy fewfnecvft kidlfqivql llefqmptnf dqdtidsnvd 361 nimasfisqk avrfdiinde evavvvggld itgvftellp cysfidntyg stnslicysn 421 vcthgqssgf rkeiklseii nksvglwtey whltpddlae inprevqrqs fifdliilee 481 rslnmataav eiygkrfdks llpdepefka lafdifepli qlhteflltp ifwklktrgk 541 fidgvgkiys kwcgeakniy lnyakamatv heiimwekkn ktkfvtwlke idnsveitrs 601 kmyhdviffg gffkslqnmp vtlrsilknt dpsmedyeyl kivikevekl nfevnqvhgl 661 aidhrklvrf skqlvlstns snatsyvnvg gstnanddda iqdklalglt yperklvlsg 721 tvykkrdlwl dptpvyiall dnclliteei skgetqkykl ierpipidyl slekrkipgt 781 skqplrnysq kehkspmhnf stpinsmrpl lkssgnhmst aygdrktsnt eisnanpntd 841 efsfkirnta tgesfkffte saevlnqwid aimesfkrna enhdlnafef tvlssefayf 901 dkdapvnlpv apegseidva lkayaqkank dscswskttr ilccedvkfe griylfvatt 961 dgiyvkyrdd ygsgfvkile lndvkrmean vklgllfvld nrklcyfnis tvvsrylaqg 1021 ntldencivg tvirdkvrff kiaddfgnsk hlfferkgki viltpefdql tnqvkyfkfy 1081 keyklpsssn nilnneiedi aifrksfavc tkktvilyqd sfedngivlp sflndkdmma 1141 hlrhphlnsl pfksatdskk rpsiesltee akkdiatcka ipvnffqisq ssffalvyde 1201 avvkincyge msdwrkdill ldfcctgasf hgnhlilvgd nliqiydlkn veqnlgelvp 1261 vqiikgkkik lasserrekt ilvlshpnil nrqllvacnp vamadhq // LOCUS NP_013530 326 aa linear PLN 30-JUN-2025 DEFINITION Tda5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013530 VERSION NP_013530.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182314.1 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09728. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..326 /product="Tda5p" /calculated_mol_wt="36546" Region 72..309 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" Site order(77,79..80,82,101..103,148..150,199..201,214,218, 247..250) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:187598" Site order(173,201,214,218) /site_type="active" /db_xref="CDD:187598" CDS 1..326 /gene="TDA5" /locus_tag="YLR426W" /coded_by="NM_001182314.1:1..981" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:16121259]" /note="hypothetical protein; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele" /db_xref="GeneID:851146" /db_xref="SGD:S000004418" ORIGIN 1 mnidclcrwv vlpllrypll valvlrwsls dsisicltiy tllinaflia nsyikrsgqv 61 awkslrefkn givlitggsk glgraivsql lqdysnltil nvdicpssvr ntrvkdlicd 121 lsddeevaal lnllkrkykn eirlivnnag vranftgfng merdnldkif kintfaplqf 181 iqelapsrhs trqcyivnia silgiltpak vaayaaskaa liafhqsysf elqnegvrni 241 rtllvtpgql ntemfagfkp prqffapvid ittlaakivr ycelgqrgql nepfycsfah 301 llmcvpyslq rivrsfsrid cclpde // LOCUS NP_013531 670 aa linear PLN 30-JUN-2025 DEFINITION RING-type E3 ubiquitin transferase MAG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013531 VERSION NP_013531.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182315.3 REFERENCE 1 (residues 1 to 670) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 670) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 670) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 670) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09729. On Jul 30, 2012 this sequence version replaced NP_013531.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..670 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..670 /product="RING-type E3 ubiquitin transferase MAG2" /EC_number="2.3.2.27" /calculated_mol_wt="76187" Region 193..259 /region_name="RING-HC_RNF10" /note="RING finger, HC subclass, found in RING finger protein 10 (RNF10) and similar proteins; cd16536" /db_xref="CDD:438198" CDS 1..670 /gene="MAG2" /locus_tag="YLR427W" /coded_by="NM_001182315.3:1..2013" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006513 protein monoubiquitination [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0070534 protein K63-linked ubiquitination [PMID:30893611]" /experiment="EXISTENCE:direct assay:GO:0070651 nonfunctional rRNA decay [PMID:30893611]" /note="Cytoplasmic RING-finger type E3 ubiquitin ligase; involved in monoubiquitination of Rps3p, a 40S subunit from decoding-defective ribosomes, leading to Fap1p-mediated K63-linked polyubiquitination, followed by dissociation of non-functional 80S ribosomes and non-functional rRNA decay (NRD) of 18S rRNA; ubiquitinated; induced in response to mycotoxin patulin; predicted to be involved in repair of alkylated DNA due to interaction with MAG1; similar to the human ring finger motif protein RNF10" /db_xref="GeneID:851147" /db_xref="SGD:S000004419" ORIGIN 1 mvepdmqkka sggsggsemd tlnatsnssk qgvsnnkrnp vskkkpgnkv sdgrdnahny 61 hgegrrkssk qqrsrtpyke tstrindqdi dlsiqeeilg gnfklrgrkt qvsinhllnf 121 qlpevereks rsssskksnr rrdehvhlhg dtfvnvnyrl lvddrfdype qncnpnvpvd 181 qekilrvivp kgqncsicls eepvaprmvt cghifclscl lnffsieetv knketgyskk 241 kkykecplcg siigpkrvkp vlyeddfdvt rlnqkpepga tvhlqlmckp hgsllplpva 301 lhldplkcgn fppanlgsik hyahimkcgv syslelyqkd ivaiqeqyei dkaiyndsgk 361 fvkqsienin dqistllaat tdlsplsndi nngldnfhfd ddlltkydds sayffyqtlv 421 asstkyflsp ldvkilltif hyyskfpesi ettvenihyd tvvteqlirr ykyighlpig 481 teialldldw rkipflpkei yeqfahelkq rrrkftmkkq kedkekklye krleqehaef 541 yrkengnslk fedsvqmath yesivsssip lnslgismlg pptnscstpq kqapshtkrt 601 iwgtsiavte dekaskenke fqdmllqrir qedssdvtds tdspptsngk rgrkkkgkvm 661 lfssnhqalg // LOCUS NP_013533 651 aa linear PLN 30-JUN-2025 DEFINITION coronin [Saccharomyces cerevisiae S288C]. ACCESSION NP_013533 VERSION NP_013533.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182317.1 REFERENCE 1 (residues 1 to 651) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 651) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 651) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 651) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09730. Method: conceptual translation. FEATURES Location/Qualifiers source 1..651 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..651 /product="coronin" /calculated_mol_wt="72422" Region 9..424 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 85..138 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 143..179 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 186..221 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 228..270 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 278..315 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <422..>603 /region_name="PTZ00449" /note="104 kDa microneme/rhoptry antigen; Provisional" /db_xref="CDD:185628" CDS 1..651 /gene="CRN1" /locus_tag="YLR429W" /coded_by="NM_001182317.1:1..1956" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:9885246]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:9822583]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:9885246]" /experiment="EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:12499356|PMID:21454476]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:9885246]" /experiment="EXISTENCE:direct assay:GO:0071846 actin filament debranching [PMID:39826693]" /experiment="EXISTENCE:direct assay:GO:0071933 Arp2/3 complex binding [PMID:39826693|PMID:12499356]" /experiment="EXISTENCE:direct assay:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:21454476]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:9885246]" /experiment="EXISTENCE:mutant phenotype:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:12499356]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:18177206]" /experiment="EXISTENCE:mutant phenotype:GO:0071846 actin filament debranching [PMID:39826693]" /experiment="EXISTENCE:mutant phenotype:GO:0071933 Arp2/3 complex binding [PMID:39826693]" /experiment="EXISTENCE:mutant phenotype:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:21454476]" /experiment="EXISTENCE:physical interaction:GO:0007015 actin filament organization [PMID:9885246]" /experiment="EXISTENCE:physical interaction:GO:0007017 microtubule-based process [PMID:9885246]" /note="Coronin; cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly; binds directly to Aim7p, forms a high affinity ternary Crn1-Gmf1-Arp2/3 complex, and binds to F-actin branch junctions to synergistically enhance Aim7p-mediated actin filament debranching" /db_xref="GeneID:851148" /db_xref="SGD:S000004421" ORIGIN 1 msgkfvrask yrhvfgqaak kelqyeklkv tnnawdsnll ktngkfiavn wnasgggafa 61 vipieevgka pdqvplfrgh taqvldtdfd pfndhriasg sddskigiwd ipenykfhdh 121 vdedgepidi kpvkfltgha rkvghvlyhp vaenvlasss gdytvklwnv etgkdmitlk 181 hpdmvtsmsf sydgnylatv ardkklrvwn ireekivseg pahtgaknqr vvwlgnsdrl 241 attgfsklsd rqigiwdafn iekgdlggfy tvdqssgilm pfydegnkil ylvgkgdgni 301 ryyefqndel felsefqste aqrgfavapk rmvnvkenev lkgfktvvdq riepvsffvp 361 rrseefqedi ypdapsnkpa ltaeewfsgk svegpilvsm rsiydgsaps fheakrpqqp 421 ttqetaleek keqpkvekpi sesekevkqe apkspsplks asssstinhv lkednsinkl 481 lkkssdidqv nnaedpsrdt sgweeaddep apikietpvt ptetkkdrtp kvepskelkp 541 epvsiatdrk qeqslpqeek ssektkspeq eksatppssi taaktaitas skeepsaart 601 spkslglkks veklstlvlq ledvvdkltk anldkderll kleqkigels k // LOCUS NP_013534 2231 aa linear PLN 30-JUN-2025 DEFINITION DNA/RNA helicase SEN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013534 VERSION NP_013534.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182318.3 REFERENCE 1 (residues 1 to 2231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2231) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 2231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 2231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 2231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09731. On Jul 30, 2012 this sequence version replaced NP_013534.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..2231 /product="DNA/RNA helicase SEN1" /calculated_mol_wt="252367" Region 106..859 /region_name="SEN1_N" /note="SEN1 N terminal; pfam12726" /db_xref="CDD:432746" Region 1179..1284 /region_name="1B_Sen1p-like" /note="1B domain of Saccharomyces cerevisiae Sen1p RNA helicase and related proteins; cd21408" /db_xref="CDD:394816" Site order(1216,1218,1246) /site_type="other" /note="putative nucleic acid substrate binding site [nucleotide binding]" /db_xref="CDD:394816" Region 1335..1656 /region_name="DEXXQc_SETX" /note="DEXXQ-box helicase domain of SETX; cd18042" /db_xref="CDD:438712" Site order(1339,1360..1365,1619,1655..1656) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:438712" Region 1634..1830 /region_name="AAA_12" /note="AAA domain; pfam13087" /db_xref="CDD:463780" CDS 1..2231 /gene="SEN1" /locus_tag="YLR430W" /gene_synonym="CIK3; NRD2" /coded_by="NM_001182318.3:1..6696" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:35857496]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:35857496|PMID:23222640|PMID:8544822]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:23141540]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0006386 termination of RNA polymerase III transcription [PMID:35857496]" /experiment="EXISTENCE:direct assay:GO:0019904 protein domain specific binding [PMID:22286094]" /experiment="EXISTENCE:direct assay:GO:0033678 5'-3' DNA/RNA helicase activity [PMID:26198638]" /experiment="EXISTENCE:direct assay:GO:0035649 Nrd1 complex [PMID:16427013]" /experiment="EXISTENCE:direct assay:GO:0043139 5'-3' DNA helicase activity [PMID:26198638]" /experiment="EXISTENCE:genetic interaction:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:27179024]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23748379]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:23741394]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9365256]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:17157256]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:23741394]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9365256]" /experiment="EXISTENCE:mutant phenotype:GO:0016180 snRNA processing [PMID:9365256]" /experiment="EXISTENCE:mutant phenotype:GO:0019904 protein domain specific binding [PMID:22286094]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0045005 DNA-templated DNA replication maintenance of fidelity [PMID:23141540]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:27718307]" /note="ATP-dependent 5' to 3' RNA/DNA and DNA helicase; subunit of the exosome-associated Nrd1p complex that mediates 3' end formation of snRNAs, snoRNAs, CUTs and some mRNAs; helicase-independent role in transcription-coupled repair; coordinates replication with transcription, associating with moving forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of juvenile ALS" /db_xref="GeneID:851150" /db_xref="SGD:S000004422" ORIGIN 1 mnsnnpdnnn snninnnnkd kdiapnsdvq latvytkaks yipqieqvyq gtnpniqeak 61 llgellqvla evpkgthlfc dpilepisif sltifsfnee atatwlknhf npilsvcdkc 121 ilnfargkck mlqhfaiqrh vphehvakfn divcqwrvea vfpilrnisv ndntginitn 181 eietamyecl cnphmlrlnk qlkatfeaif kffydtkhrl ldvtnplsik tfisgvifcw 241 cegskeenew sraflkdlys rnfhinlsnl tpdiieevyi hilflqnpan wteivvsqfw 301 srllpvfnlf dkdvfieyfq vpknveslkk tfkfplepif kmwynhlsks yhdkpldfll 361 rgltmflnkf gsefwskiep ftfhsildii fnrdsfpikl ikiqdnpive hqtevyfqlt 421 gsvtdllswt lpfyhalsps kriqmvrkvs maflriiany pslksipkac lmnsatallr 481 avltikener amlykndefe tvlltktdsr allnnpliqd iiirsasnpn dfypglgaas 541 asvatstmmv laecidfdil llchrtfkly sgkpiseipi stnvlenvtn kidlrsfhdg 601 pllakqllvs lkninglliv psntavaeah nalnqkflll strlmekfad ilpgqlskil 661 adedasqgfw scifssdkhl yqaatnilyn tfdvegrleg ilailnsnlt vnlkninvml 721 qrlincefye pcpravrvlm dvvsafvdpi sgvfanfqtl ksqntekefl kfwescwlfl 781 dtiykftlkw askydysele nftkdtldls rslvdsfref sdilhdqtkn lllnvletfk 841 nmlywlrlsd evllescvrl iistsdlahe khvkvddslv emmakyaska krfsnklteq 901 qaseilqkak ifnkalteev ateaenyrke kelsrlgkvi dltdsvpasp slspslssti 961 asssaesrad ylqrkalsss itgrprvaqp kitsfgtfqs sanaklhrtk pvkplskmel 1021 armqllnnrv vhppsapafh tksrglsnkn ddssseesdn diesarelfa iakakgkgiq 1081 tvdingkvvk rqtaaelakq elehmrkrln vdmnplyeii lqwdytrnse ypddepigny 1141 sdvkdffnsp adyqkvmkpl llleswqglc ssrdredykp fsiivgnrta vsdfydvyas 1201 vakqviqdcg isesdlivma ylpdfrpdkr lssddfkkaq htclakvrtl kntkggnvdv 1261 tlrihrnhsf skfltlrsei ycvkvmqmtt iereystleg leyydlvgqi lqakpsppvn 1321 vdaaeietvk ksyklntsqa eaivnsvske gfsliqgppg tgktktilgi igyflstkna 1381 sssnvikvpl eknssnteql lkkqkilica psnaavdeic lrlksgvydk qghqfkpqlv 1441 rvgrsdvvnv aikdltleel vdkrigerny eirtdpeler kfnnavtkrr elrgkldses 1501 gnpespmste disklqlkir elskiinelg rdrdemrekn svnyrnrdld rrnaqahila 1561 vsdiicstls gsahdvlatm gikfdtviid eacqctelss iiplryggkr cimvgdpnql 1621 pptvlsgaas nfkynqslfv rmeknsspyl ldvqyrmhps iskfpssefy qgrlkdgpgm 1681 dilnkrpwhq leplapykff diisgrqeqn aktmsytnme eirvaielvd ylfrkfdnki 1741 dftgkigiis pyreqmqkmr kefaryfggm inksidfnti dgfqgqekei iliscvradd 1801 tkssvgflkd frrmnvaltr aktsiwvlgh qrslaksklw rdliedakdr sclayacsgf 1861 ldprnnraqs ilrkfnvpvp seqeddyklp meyitqgpde vksnkdtkkr rvvdegeead 1921 kavkkkkkek kkekkkskad dkkknnkkae spstssgtkk kssifggmsv psavvpktfp 1981 dvdsnkkaaa vvgkkknnkh vcfsddvsfi prndepeikv trslssvlke kqlglketrt 2041 isppeisnne ddddeddytp sisdsslmks eangrnnrva shnqnfsasi yddpqvsqak 2101 qtqvpaaitk hrssnsvlsg gssriltasd ygepnqngqn ganrtlsqhv gnanqystap 2161 vgtgelhetl pahpqdsypa eaedpydlnp hpqpqssafk gpgsgptgtr nssrrnasss 2221 pfipkkrkpr s // LOCUS NP_013535 453 aa linear PLN 30-JUN-2025 DEFINITION Atg23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013535 VERSION NP_013535.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182319.1 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09732. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..453 /product="Atg23p" /calculated_mol_wt="51409" Region <149..>329 /region_name="DUF3584" /note="Protein of unknown function (DUF3584); pfam12128" /db_xref="CDD:432349" CDS 1..453 /gene="ATG23" /locus_tag="YLR431C" /gene_synonym="CVT23" /coded_by="NM_001182319.1:1..1362" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569|PMID:14504273]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:14734026]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:14504273]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:17135291]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /note="Peripheral membrane protein required for autophagy and CVT; required for cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p" /db_xref="GeneID:851151" /db_xref="SGD:S000004423" ORIGIN 1 melnqvlekk eqilqylgtl vglhekalsd vnsasqvtsi rkditiclnd lcrindllvs 61 hdgllkreig sllrdkqell elnereqllw kerkswhikq etdaapadyv idkdaiitis 121 shhrtslnky iesvgaenti lsntddsdam ieevqnaess adqmirnykl lqlshkqaks 181 eiirletllr dfkkdnkfie eelkrqsgri rsemgnidfh lskieeskhq lmkrigfesp 241 ltqekslsek ifnlrlssad edynerqtin mknfvhmkdl ielkiedlqe qlmrnkness 301 tvltqrelwl dcqkkvgdle sklitklrss snskippnem seminstiqy lnnlldssde 361 kltttlisne rdvlskacee lhsesttaqd gssalpskpi dihkshkgsn assnlkqpst 421 psflvasksp pkigisesvv nankndaisk kve // LOCUS NP_013536 523 aa linear PLN 30-JUN-2025 DEFINITION IMP dehydrogenase IMD3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013536 VERSION NP_013536.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182320.3 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09733. On Jul 30, 2012 this sequence version replaced NP_013536.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..523 /product="IMP dehydrogenase IMD3" /EC_number="1.1.1.205" /calculated_mol_wt="56454" Region 21..518 /region_name="PTZ00314" /note="inosine-5'-monophosphate dehydrogenase; Provisional" /db_xref="CDD:240355" CDS 1..523 /gene="IMD3" /locus_tag="YLR432W" /coded_by="NM_001182320.3:1..1572" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /note="Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD3 has a paralog, IMD4, that arose from the whole genome duplication" /db_xref="GeneID:851152" /db_xref="SGD:S000004424" ORIGIN 1 maavrdykta lefakslprl dglsvqelmd sktrggltyn dflvlpglvd fpssevslqt 61 kltrnitlnt pfvsspmdtv tesemaifma llggigfihh nctpedqadm vrrvknyeng 121 finnpivisp tttvgeaksm kerfgfsgfp vtedgkrngk lmgivtsrdi qfvednsllv 181 qdvmtknpvt gaqgitlseg neilkkikkg kllivddngn lvsmlsrtdl mknqnyplas 241 ksattkqllc gaaigtidad kerlrllvea gldvvildss qgnsifqlnm ikwiketfpd 301 leiiagnvat reqaanliaa gadglrigmg sgsicitqev macgrpqgta vynvcefanq 361 fgipcmadgg vqnighitka lalgsstvmm ggmlagttes pgeyfyqdgk rlkayrgmgs 421 idamqktgtk gnastsryfs esdsvlvaqg vsgavvdkgs ikkfipylyn glqhscqdig 481 yksltllken vqsgkvrfef rtasaqlegg vhnlhsyekr lhn // LOCUS NP_013537 553 aa linear PLN 30-JUN-2025 DEFINITION calcineurin catalytic subunit A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013537 VERSION NP_013537.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182321.1 REFERENCE 1 (residues 1 to 553) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 553) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 553) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 553) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09734. Method: conceptual translation. FEATURES Location/Qualifiers source 1..553 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..553 /product="calcineurin catalytic subunit A" /EC_number="3.1.3.16" /calculated_mol_wt="62871" Region 70..381 /region_name="MPP_PP2B" /note="PP2B, metallophosphatase domain; cd07416" /db_xref="CDD:277361" Site order(82,84,119,121,147,179,188,228,317,350,377) /site_type="other" /note="CN-CyPA-CsA complex [polypeptide binding]" /db_xref="CDD:277361" Site order(119,121,147,151,179..180,228,261,290,317,319) /site_type="active" /db_xref="CDD:277361" Site order(119,121,147,179,228,317) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277361" CDS 1..553 /gene="CNA1" /locus_tag="YLR433C" /gene_synonym="CMP1" /coded_by="NM_001182321.1:1..1662" /experiment="EXISTENCE:direct assay:GO:0004723 calcium-dependent protein serine/threonine phosphatase activity [PMID:1321337]" /experiment="EXISTENCE:direct assay:GO:0005955 calcineurin complex [PMID:1321337]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:1651503]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:8798496]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:1651503]" /note="Calcineurin A; one isoform (the other is Cmp2p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CNA1 has a paralog, CMP2, that arose from the whole genome duplication" /db_xref="GeneID:851153" /db_xref="SGD:S000004425" ORIGIN 1 mskdlnssri kiikpndsyi kvdrkkdltk yelengkvis tkdrpiasvp aitgkipsde 61 evfdsktglp nhsflrehff hegrlskeqa ikilnmstva lskepnllkl kapiticgdi 121 hgqyydllkl fevggdpaei dylflgdyvd rgafsfecli ylyslklnnl grfwmlrgnh 181 eckhltsyft fknemlhkyd mevydaccrs fnvlplaalm ngqyfcvhgg ispelksved 241 vnkinrfrei psrglmcdll wadpvenydd ardgsefdqs edefvpnslr gcsfaftfka 301 sckflkangl lsiiraheaq dagyrmyknn kvtgfpslit mfsapnyldt yhnkaavlky 361 eenvmnirqf hmsphpywlp dfmdvftwsl pfvgekvtsm lvsilnicse qeldpesepk 421 aaeetvkara natketgtps dekassaile detrrkalrn kilaiakvsr mfsvlreese 481 kveylktmna gvlprgalar gteglnetls tfekarkedl ineklppsls eveqekikyy 541 ekilkgaekk pql // LOCUS NP_013539 205 aa linear PLN 30-JUN-2025 DEFINITION Tsr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013539 VERSION NP_013539.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182323.3 REFERENCE 1 (residues 1 to 205) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 205) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 205) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 205) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 205) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09735. On Jul 30, 2012 this sequence version replaced NP_013539.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..205 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..205 /product="Tsr2p" /calculated_mol_wt="23582" Region 32..110 /region_name="WGG" /note="Pre-rRNA-processing protein TSR2; pfam10273" /db_xref="CDD:463040" CDS 1..205 /gene="TSR2" /locus_tag="YLR435W" /coded_by="NM_001182323.3:1..618" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25144938|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:25144938]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12837249]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:25144938]" /note="Protein with a potential role in pre-rRNA processing" /db_xref="GeneID:851154" /db_xref="SGD:S000004427" ORIGIN 1 mstqyideta fvqaeqgktn lmfsdekqqa rfelgvsmvi ykwdaldvav enswggpdsa 61 ekrdwitgiv vdlfknekvv daalieetll yamidefetn veddsalpia veviniyndc 121 fnlnynkvek lylewqekqr tkkskrvvhi egdddedded vedyddeded eemdevvpdl 181 vsskpepivd edgfelvqpk grrkh // LOCUS NP_013540 1274 aa linear PLN 30-JUN-2025 DEFINITION Ecm30p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013540 VERSION NP_013540.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182324.1 REFERENCE 1 (residues 1 to 1274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1274) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09736. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1274 /product="Ecm30p" /calculated_mol_wt="144922" Region 110..1001 /region_name="Hid1" /note="High-temperature-induced dauer-formation protein; pfam12722" /db_xref="CDD:463680" CDS 1..1274 /gene="ECM30" /locus_tag="YLR436C" /coded_by="NM_001182324.1:1..3825" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:851156" /db_xref="SGD:S000004428" ORIGIN 1 mgntdsksss illnhcialv rpedadassp srtsspspsl svdadplsln lsifkldsgp 61 dvealfsdkp nvpldtvfnd fyldfisvdv qdfsinssfk kilhiissln ppnfnnlivf 121 lslyiilsan slpasrtglh ssrlinaikt lsilipiyfd rvksstqdhy dvfwatqhei 181 eglplqnipl gerlllailk lafqdnftta vtahpselwe igiltnsnky rsllnmhhqw 241 hlfanrllll rllaalfssd lytsggkqdi nmflvywctq mpkdksiqft ssllnctmrf 301 ilnnnkdfqs lkanffssda tasnwqtlyf qfvqsclhvl nlsmsykaqd nvitifltql 361 qreydlklil ssfikifkyp idlaieqesn ifnftnnkhi dasrrravst sshdnssssh 421 aslpssssaa yhtkpqtkpq lpeihpllip mtilmtnlid cnkcfqnyfa dkfasrfiif 481 siyylkyydy sslssssstt rsnssttsng tsndtsners ivelnensvs qillpllnhl 541 lliltskklv lfkmlqtfnl nyytnnlpnf yklsningdi nnltfrdftv iqlsnlildn 601 ikfnlqpnpi fyeliynllp indeiltssh knddshddli llsakkksas psaatsshts 661 ssklsynaam sllyvlskss nkvylttyat pvfktkdipy mispgfkmdl lalllrsiti 721 fftlyfddae nllfamvrhq sithqindsi nsiskaldmn pnlnshimtl kqmgfnrkvq 781 wkdfyqfeei tdlpqvnlys sanqqhqnqq qgqndnrgqn qnedpgqene sptpyllfnp 841 aslenetpgt vkhfsstnhd knyqviafid fksdsnlnlq hqleywphrp qwptpltfth 901 kcknpkyenf nevwsgtvyl qillrvikqi lskvpeipri ksvqyfetls klsalrsdil 961 ttihprlpld vrrlttfqpl smhtndkllm wfhiatwani ftqtsfkyee tfshelrqfe 1021 slldisidec egntiskptt drlgyirrsr gqssvslert isagsgvstp tmalnrtksn 1081 gsgnlmnyff qntaqnhfqh lrsssssssi tlekttsnss sirtrpnshh vapetnnnns 1141 tngnsnnssn ggfsffkwkw ggnnsnggsd dtkasqrdpn vstsiitdnl nsymfeeeis 1201 pgvvnniien niwvgtdirl fkianfrkes fsflemtssf fkkfkfinsd ndnynnnefd 1261 dntqlrytsr glyr // LOCUS NP_013541 133 aa linear PLN 30-JUN-2025 DEFINITION Dif1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013541 VERSION NP_013541.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182325.3 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09737. On Jul 30, 2012 this sequence version replaced NP_013541.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..133 /product="Dif1p" /calculated_mol_wt="15034" Region 38..>66 /region_name="RNR_inhib" /note="Ribonucleotide reductase inhibitor; pfam08591" /db_xref="CDD:430095" CDS 1..133 /gene="DIF1" /locus_tag="YLR437C" /gene_synonym="SDH1" /coded_by="NM_001182325.3:1..402" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18838542|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:18838542]" /note="Protein that regulates nuclear import of Rnr2p and Rnr4p; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half shows similarity to S. pombe Spd1 protein; DIF1 has a paralog, SML1, that arose from the whole genome duplication" /db_xref="GeneID:851157" /db_xref="SGD:S000004429" ORIGIN 1 mdaqlewass lvpkrqlqqq qqqqeqqqqq qqdfhkdqlm tvgmrirqrv dqgyasrtps 61 tsdaslqpgv irdyssvivp qftrsplpta nslppmlinq rtmsteassl ekwdvaepaa 121 ehetmvngsk rrl // LOCUS NP_013542 424 aa linear PLN 30-JUN-2025 DEFINITION ornithine-oxo-acid transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013542 VERSION NP_013542.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182326.1 REFERENCE 1 (residues 1 to 424) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 424) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 424) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 424) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 424) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09738. Method: conceptual translation. FEATURES Location/Qualifiers source 1..424 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..424 /product="ornithine-oxo-acid transaminase" /EC_number="2.6.1.13" /calculated_mol_wt="45955" Region 8..422 /region_name="Orn_aminotrans" /note="ornithine aminotransferase; TIGR01885" /db_xref="CDD:273853" Site order(109..111,145..146,148,208,241,243..244,272) /site_type="active" /note="inhibitor-cofactor binding pocket [active]" /db_xref="CDD:99735" Site order(110..111,145..146,208,241,244,272) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99735" Site 272 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99735" CDS 1..424 /gene="CAR2" /locus_tag="YLR438W" /coded_by="NM_001182326.1:1..1275" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:205532]" /experiment="EXISTENCE:mutant phenotype:GO:0004587 ornithine aminotransferase activity [PMID:3036506]" /experiment="EXISTENCE:mutant phenotype:GO:0006591 ornithine metabolic process [PMID:3036506]" /note="L-ornithine transaminase (OTAse); catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive; protein abundance increases in response to DNA replication stress; human homolog OAT complements yeast null mutant" /db_xref="GeneID:851158" /db_xref="SGD:S000004430" ORIGIN 1 mseatlsskq tiewenkysa hnyhplpvvf hkakgahvwd pegklyldfl saysavnqgh 61 chphiikalt eqaqtltlss rafhndvyaq fakfvteffg fetvlpmntg aeavetalkl 121 arrwgymkkn ipqdkaiilg aegnfhgrtf gaislstdye dsklhfgpfv pnvasghsvh 181 kiryghaedf vpilespegk nvaaiilepi qgeagivvpp adyfpkvsal crkhnvlliv 241 deiqtgigrt gellcydhyk aeakpdivll gkalsggvlp vscvlsshdi mscftpgshg 301 stfggnplas rvaiaalevi rdeklcqraa qlgssfiaql kalqaksngi isevrgmgll 361 taividpska ngktawdlcl lmkdhgllak pthdhiirla pplviseedl qtgvetiakc 421 idll // LOCUS NP_013543 89 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit LSM3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013543 VERSION NP_013543.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184308.3 REFERENCE 1 (residues 1 to 89) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 89) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 89) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 89) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 89) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09739. On Jul 30, 2012 this sequence version replaced NP_013543.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..89 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..89 /product="U4/U6-U5 snRNP complex subunit LSM3" /calculated_mol_wt="9899" Region 4..78 /region_name="LSm3" /note="Like-Sm protein 3; cd01730" /db_xref="CDD:212477" Site order(8,11..12,17,19..21,24,26,31..34,37..38,40,65..77) /site_type="other" /note="putative oligomer interface [polypeptide binding]" /db_xref="CDD:212477" Site order(16..22,24..36,38..42) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212477" Site order(34,36,69) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:212477" Site 65..76 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212477" CDS 1..89 /gene="LSM3" /locus_tag="YLR438C-A" /gene_synonym="SMX4; USS2" /coded_by="NM_001184308.3:1..270" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10369684]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:10369684|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15075370]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419]" /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970]" /experiment="EXISTENCE:physical interaction:GO:0005732 sno(s)RNA-containing ribonucleoprotein complex [PMID:15075370]" /note="Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:851159" /db_xref="SGD:S000006434" ORIGIN 1 metpldllkl nldervyikl rgartlvgtl qafdshcniv lsdavetiyq lnneelsese 61 rrcemvfirg dtvtlistps edddgavei // LOCUS NP_013544 319 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL29m MRPL4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013544 VERSION NP_013544.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182327.1 REFERENCE 1 (residues 1 to 319) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 319) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 319) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 319) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09740. Method: conceptual translation. FEATURES Location/Qualifiers source 1..319 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..319 /product="mitochondrial 54S ribosomal protein uL29m MRPL4" /calculated_mol_wt="36834" Region 68..159 /region_name="MRP-L47" /note="Mitochondrial 39-S ribosomal protein L47 (MRP-L47); pfam06984" /db_xref="CDD:369158" CDS 1..319 /gene="MRPL4" /locus_tag="YLR439W" /gene_synonym="uL29m" /coded_by="NM_001182327.1:1..960" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:20404317|PMID:3060376]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:20404317|PMID:3060376]" /experiment="EXISTENCE:genetic interaction:GO:1902775 mitochondrial large ribosomal subunit assembly [PMID:31053642]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:7828914]" /note="Mitochondrial ribosomal large subunit of the polypeptide tunnel exit; required for mitochondrial ribosome large subunit assembly; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit" /db_xref="GeneID:851160" /db_xref="SGD:S000004431" ORIGIN 1 mwkrsfhsqg gplrartkft kpkpkqpvlp kdkirpptql thhsnnlrit epippttsnl 61 rcpddhplwq ffsnkkfirs addlppsshi rpwsipelrh ksfndlhslw ynclreqnvl 121 arenhllkni vgsthdefse lsnsirttmw qirhvlnere laysasrefl qdeserkkfl 181 dtlandyfln kdipddevas mltrfqlaif gisetiqdnt vdinfidgik flanlklqrf 241 kdsndlisei sqepitdvge sfilftsdfe phavqeacva ikdlrkspdn kvpkldelpt 301 vrkylkqlih assveqata // LOCUS NP_013545 709 aa linear PLN 30-JUN-2025 DEFINITION Sec39p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013545 VERSION NP_013545.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182328.3 REFERENCE 1 (residues 1 to 709) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 709) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 709) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 709) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09741. On Jul 30, 2012 this sequence version replaced NP_013545.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..709 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..709 /product="Sec39p" /calculated_mol_wt="82265" Region 7..688 /region_name="Sec39" /note="Secretory pathway protein Sec39; pfam08314" /db_xref="CDD:429913" CDS 1..709 /gene="SEC39" /locus_tag="YLR440C" /gene_synonym="DSL3" /coded_by="NM_001182328.3:1..2130" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591|PMID:15942868]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15942868|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:15958492]" /experiment="EXISTENCE:direct assay:GO:0070939 Dsl1/NZR complex [PMID:19151722]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:15958492]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:15242642]" /experiment="EXISTENCE:mutant phenotype:GO:0032581 ER-dependent peroxisome organization [PMID:19346454]" /experiment="EXISTENCE:physical interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:15958492]" /experiment="EXISTENCE:physical interaction:GO:0070939 Dsl1/NZR complex [PMID:15958492]" /note="Component of the Dsl1p tethering complex; this complex interacts with ER SNAREs Sec20p and Use1p; mediates Sey1p-independent homotypic ER fusion; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope" /db_xref="GeneID:851161" /db_xref="SGD:S000004432" ORIGIN 1 mleeqlylla cifasradtr nikklstrlg sqskyleilc vlwpelddpk nllflrelee 61 evqspegeet tdedvivell esdsslipli esdtttrsnr yhelqefisk klnnktlenf 121 eewlrerili cnemipetpl lysvlwetak skvlstkfig wvegvlkpld hlnkrlhlif 181 kinewekmpd selfkiifdg vedmqgyigi adviedelap tlsygkkwet fiteffnkqq 241 fslksdtnyq lfiklyysle kgvkdnseas rklqsnvvdi lfhnsenlfn lsslthklde 301 lwsilsgfpd eitieeqkti talemkqfme ffikcstkfs fkeifaitqe eesaqlahfs 361 slcheefnka neissflqam yetvldiskd dkiftrismd eklysileil lqmnefayie 421 aiierfdysn ntqiyellvk ffwhffnnas nglrkepemk kasqtlqiiq khmsqragtn 481 ltklevllei sdklshysin lnkshngard tafkpsnile yrdcpldiis nllelnprly 541 kdlpttksll fgiydslsin regqtgkvev dlmvlhidya lvnldfgtay elgkqvfeic 601 qeagqhmmka lgdehwltfy qmgkfvdpnw vdneipteii vlqmsilgrl levcpleeve 661 ivtsqwstle lelsardlvk dkyaldgqnd nkskvggiar eifhnvtnf // LOCUS NP_013546 255 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS1 RPS1A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013546 VERSION NP_013546.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182329.1 REFERENCE 1 (residues 1 to 255) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 255) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 255) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 255) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09742. Method: conceptual translation. FEATURES Location/Qualifiers source 1..255 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..255 /product="40S ribosomal protein eS1 RPS1A" /calculated_mol_wt="28612" Region 15..221 /region_name="Ribosomal_S3Ae" /note="Ribosomal S3Ae family; pfam01015" /db_xref="CDD:425987" CDS 1..255 /gene="RPS1A" /locus_tag="YLR441C" /gene_synonym="RP10A" /coded_by="NM_001182329.1:1..768" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Ribosomal protein of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1A has a paralog, RPS1B, that arose from the whole genome duplication" /db_xref="GeneID:851162" /db_xref="SGD:S000004433" ORIGIN 1 mavgknkrls kgkkgqkkrv vdpftrkewf dikapstfen rnvgktlvnk stglksasda 61 lkgrvvevcl adlqgsedhs frkiklrvde vqgknlltnf hgmdfttdkl rsmvrkwqtl 121 ieanvtvkts ddyvlrifai aftrkqanqv krhsyaqssh irairkvise iltkevqgst 181 laqltsklip evinkeiena tkdifplqni hvrkvkllkq pkfdvgalma lhgegsgeek 241 gkkvtgfkde vletv // LOCUS NP_013547 978 aa linear PLN 30-JUN-2025 DEFINITION chromatin-silencing protein SIR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013547 VERSION NP_013547.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182330.3 REFERENCE 1 (residues 1 to 978) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 978) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 978) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 978) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 978) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 978) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 978) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 978) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 978) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09743. On Jul 30, 2012 this sequence version replaced NP_013547.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..978 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..978 /product="chromatin-silencing protein SIR3" /calculated_mol_wt="111229" Region 5..189 /region_name="BAH_Orc1p_Yeast" /note="BAH, or Bromo Adjacent Homology domain, as present in Orc1p, which again is part of the Saccharomyces cerevisiae Sir1-origin recognition complex, and as present in Sir3p. The Orc1p BAH doman functions in epigenetic silencing. BAH domains are found in a...; cd04720" /db_xref="CDD:240071" Site order(61,64..65,93) /site_type="active" /note="Sir1p binding site [active]" /db_xref="CDD:240071" Region <569..887 /region_name="PTZ00112" /note="origin recognition complex 1 protein; Provisional" /db_xref="CDD:240274" Region 737..833 /region_name="AAA_lid_10" /note="AAA lid domain; pfam17872" /db_xref="CDD:407729" CDS 1..978 /gene="SIR3" /locus_tag="YLR442C" /gene_synonym="CMT1; MAR2; STE8" /coded_by="NM_001182330.3:1..2937" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:16956377|PMID:9710643]" /experiment="EXISTENCE:direct assay:GO:0000792 heterochromatin [PMID:20176978]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18195043]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:29795547]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:19099415]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:19099415]" /experiment="EXISTENCE:direct assay:GO:0005677 chromatin silencing complex [PMID:9122169]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9150138]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:19217406]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16581798]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:27122604]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0008156 negative regulation of DNA replication [PMID:29795547]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:3297920|PMID:16581798]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:16908543]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:1913809|PMID:31599702|PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:26399229|PMID:27122604]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:17660569]" /experiment="EXISTENCE:mutant phenotype:GO:0097695 establishment of protein-containing complex localization to telomere [PMID:26218225]" /note="Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication" /db_xref="GeneID:851163" /db_xref="SGD:S000004434" ORIGIN 1 maktlkdldg wqviitddqg rviddnnrrr srkrggenvf lkrisdglsf gkgesvifnd 61 nvtetysvyl iheirlntln nvveiwvfsy lrwfelkpkl yyeqfrpdli kedhplefyk 121 dkffnevnks elyltaelse iwlkdfiavg qilpesqwnd ssidkiedrd flvryacept 181 aekfvpidif qiirrvkeme pkqsdeylkr vsvpvsgqkt nrqvmhkmgv ersskrlakk 241 psmkkikiep sadddvnngn ipsqrgtstt hgsispqees vspnissasp saltsptdss 301 kilqkrsisk elivseeipi nsseqesdye pnnetsvlss kpgskpekts telvdgrenf 361 vyannpevsd dggleeetde vssessdeai ipvnkrrgah gselsskirk ihiqetqefs 421 knyttetdne mngngkpgip rgntkihsmn enptpekgna kmidfatlsk lkkkyqiild 481 rfapdnqvtd ssqlnkltde qssldvagle dkfrkacsss gretilsnfn adinleesir 541 eslqkrellk sqvedftrif lpiydslmss qnklfyitna ddstkfqlvn dvmdelitss 601 arkelpifdy ihidalelag mdalyekiwf aiskenlcgd islealnfyi tnvpkakkrk 661 tliliqnpen llsekilqyf ekwissknsk lsiicvgghn vtireqinim pslkahftei 721 klnkvdknel qqmiitrlks llkpfhvkvn dkkemtiynn iregqnqkip dnvivinhki 781 nnkitqliak nvanvsgste kafkiceaav eiskkdfvrk gglqkgklvv sqemvpryfs 841 eaingfkdet iskkiigmsl lmrtflytla qetegtnrht laletvlikm vkmlrdnpgy 901 kaskeikkvi cgawepaiti eklkqfswis vvndlvgekl vvvvleepsa simvelklpl 961 einyafsmde efknmdci // LOCUS NP_013548 448 aa linear PLN 30-JUN-2025 DEFINITION Ecm7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013548 VERSION NP_013548.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182331.1 REFERENCE 1 (residues 1 to 448) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 448) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 448) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 448) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09744. Method: conceptual translation. FEATURES Location/Qualifiers source 1..448 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..448 /product="Ecm7p" /calculated_mol_wt="50197" Region 96..308 /region_name="SUR7" /note="SUR7/PalI family; cl24030" /db_xref="CDD:420163" CDS 1..448 /gene="ECM7" /locus_tag="YLR443W" /gene_synonym="ZRG15" /coded_by="NM_001182331.1:1..1347" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006816 calcium ion transport [PMID:21252230]" /note="Putative integral membrane protein with a role in calcium uptake; non-essential protein; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency" /db_xref="GeneID:851164" /db_xref="SGD:S000004435" ORIGIN 1 mvmsrirdti arpfqnltal ekvvqwlrlg ttlliisfgl altvgplssp rtlymsrldt 61 ysadittglf tvlresmeqs tsteenngvg lttselyilt aytesqiknv pqyitvslyg 121 rcdstytmve vfdsegnmhs vknsttkstc ssigtdylfd yrevleslgl diildyaynk 181 igsqqaessa yttymrslkh kkanvlhlly avisfqvcml ffmiwyyyik grfmnalker 241 alvhinslls lvvfigglis sislawvnyt iqsrintele afgfsyhlgv twfallwcfa 301 glisvsclaw sglewcisdn gtsygggidd kflgyqagvf tdadlddets ysqrypqrqs 361 tsgeaelmrn sdtmatirkt sdvdlnsend antsldhgnp tanisnggkh epfatreefe 421 lqdirfrssn dseesmqrvi kpssalqf // LOCUS NP_013550 188 aa linear PLN 30-JUN-2025 DEFINITION Gmc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013550 VERSION NP_013550.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182333.3 REFERENCE 1 (residues 1 to 188) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 188) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 188) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 188) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09745. On Jul 30, 2012 this sequence version replaced NP_013550.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..188 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..188 /product="Gmc2p" /calculated_mol_wt="22234" CDS 1..188 /gene="GMC2" /locus_tag="YLR445W" /coded_by="NM_001182333.3:1..567" /experiment="EXISTENCE:direct assay:GO:0000795 synaptonemal complex [PMID:23326245]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:genetic interaction:GO:0051321 meiotic cell cycle [PMID:22194413]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:23326245]" /experiment="EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:23326245]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:22194413]" /experiment="EXISTENCE:mutant phenotype:GO:0070193 synaptonemal complex organization [PMID:23326245|PMID:22194413]" /note="Protein involved in meiotic crossing over; component of the Synaptonemal Complex (SC) along with Ecm11p; required for the efficient loading of the SC transverse filament protein, Zip1p; promotes SUMOylation of Ecm11p; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor; also detected in peroxisomes" /db_xref="GeneID:851166" /db_xref="SGD:S000004437" ORIGIN 1 msdttevprq ssendqdnnl ertnslkspd vtnnipslfk laaewqinnp qetfqnhile 61 ndvlkkinei thliresykd lssqdgmmsk qqqekmdwdl fctvpvniie qytkdmdeiy 121 ekmerlakqq rlwcesafqi dvercgdsil naetwmkkke rhleykniem ersaneiket 181 iqrltddr // LOCUS NP_013551 433 aa linear PLN 30-JUN-2025 DEFINITION hexokinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013551 VERSION NP_013551.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182334.1 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09746. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..433 /product="hexokinase" /EC_number="2.7.1.59" /calculated_mol_wt="48838" Region 19..423 /region_name="ASKHA_NBD_HK" /note="nucleotide-binding domain (NBD) of the hexokinase (HK) domain family; cd24000" /db_xref="CDD:466850" CDS 1..433 /gene="NGK1" /locus_tag="YLR446W" /coded_by="NM_001182334.1:1..1302" /experiment="EXISTENCE:direct assay:GO:0045127 N-acetylglucosamine kinase activity [PMID:36216916]" /experiment="EXISTENCE:genetic interaction:GO:0006048 UDP-N-acetylglucosamine biosynthetic process [PMID:38622055]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:38622055]" /experiment="EXISTENCE:mutant phenotype:GO:0006048 UDP-N-acetylglucosamine biosynthetic process [PMID:38622055]" /experiment="EXISTENCE:mutant phenotype:GO:0045127 N-acetylglucosamine kinase activity [PMID:36216916]" /note="N-acetylglucosamine (GlcNAc) kinase; requires a divalent cation and a broad range of NTPs as phosphoryl donor to generate GlcNAc-6-phosphate, a substrate for glycan biosynthesis; promotes UDP-GlcNAc biosynthesis a precursor for chitin production; phylogenically distinct from known GlcNAc kinases and hexokinases; transcript is upregulated during sporulation and the unfolded protein response; contains a hexokinase-like ATPase domain; non-essential gene" /db_xref="GeneID:851167" /db_xref="SGD:S000004438" ORIGIN 1 mtiestlare leslilpads ivnvvdqfqe ellsrlqtnt ismlpqclvp dkrsrwnped 61 kiltidfggt rlkfaiislp qivieyndaf eltynivdsn ffnqiiytic trlaangyik 121 kknesseask ffvsvtfsfp lnpegevvam gkgfvmtdtl qgstvkqliq ssfhriisen 181 ieeffctmnv chvindaiav sltskficen dsisliigtg tnacfevpyg ylppfkrdal 241 retlpssynk etlnfkhvli nseigfigkn vialqpfdih gaisyemple cvtsgkwlpl 301 slknillqyn iipknfpvef ngelvcqlae dctnawfene hyalicqiar llikraafyv 361 aaivqaidii tgcknynfih igyvgsflhn snfyreqiky yssihiklqf lnhsnllgaa 421 iatylnksdn qvq // LOCUS NP_013552 345 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V0 sector ATPase subunit d [Saccharomyces cerevisiae S288C]. ACCESSION NP_013552 VERSION NP_013552.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182335.3 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09747. On Jul 30, 2012 this sequence version replaced NP_013552.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..345 /product="H(+)-transporting V0 sector ATPase subunit d" /calculated_mol_wt="39660" Region 13..338 /region_name="vATP-synt_AC39" /note="ATP synthase (C/AC39) subunit; pfam01992" /db_xref="CDD:426553" CDS 1..345 /gene="VMA6" /locus_tag="YLR447C" /coded_by="NM_001182335.3:1..1038" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:8509410|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0007034 vacuolar transport [PMID:8509410]" /experiment="EXISTENCE:direct assay:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:8509410]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:8509410]" /experiment="EXISTENCE:mutant phenotype:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:8509410]" /note="Subunit d of the V0 integral membrane domain of V-ATPase; part of the electrogenic proton pump found in the endomembrane system; required for V1 domain assembly on the vacuolar membrane; the V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase) has five subunits" /db_xref="GeneID:851168" /db_xref="SGD:S000004439" ORIGIN 1 megvyfnidn gfiegvvrgy rngllsnnqy inltqcdtle dlklqlsstd ygnflssvss 61 eslttsliqe yassklyhef nyirdqssgs trkfmdyity gymidnvalm itgtihdrdk 121 geilqrchpl gwfdtlptls vatdleslye tvlvdtplap yfkncfdtae elddmnieii 181 rnklykayle dfynfvteei pepakecmqt llgfeadrrs inialnslqs sdidpdlksd 241 llpnigklyp latfhlaqaq dfegvraala nvyeyrgfle tgnledhfyq lemelcrdaf 301 tqqfaistvw awmkskeqev rnitwiaeci aqnqrerinn yisvy // LOCUS NP_013553 176 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL6 RPL6B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013553 VERSION NP_013553.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182336.1 REFERENCE 1 (residues 1 to 176) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 176) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 176) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 176) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09748. Method: conceptual translation. FEATURES Location/Qualifiers source 1..176 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..176 /product="60S ribosomal protein eL6 RPL6B" /calculated_mol_wt="19855" Region 26..176 /region_name="KOW_RPL6" /note="KOW motif of Ribosomal Protein L6; cd13156" /db_xref="CDD:240520" Site order(26,28,44..48,50,61..62,69..73,75,77..80,82..83,108, 131,134..135,157,160..162,166..167) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240520" CDS 1..176 /gene="RPL6B" /locus_tag="YLR448W" /coded_by="NM_001182336.1:1..531" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:3282992]" /note="Ribosomal 60S subunit protein L6B; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6B has a paralog, RPL6A, that arose from the whole genome duplication" /db_xref="GeneID:851169" /db_xref="SGD:S000004440" ORIGIN 1 mtaqqapkwy psedvaapkk trkavrpqkl raslvpgtvl illagrfrgk rvvylkhled 61 ntllvtgpfk vngvplrrvn aryviatstk vsvegvnvek fnveyfakek ltkkekkean 121 lfpeqqtkei ktervedqkv vdkallaeik ktpllkqyls asfslkngdk phllkf // LOCUS NP_013554 392 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase FPR4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013554 VERSION NP_013554.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182337.3 REFERENCE 1 (residues 1 to 392) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 392) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 392) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 392) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09749. On Jul 30, 2012 this sequence version replaced NP_013554.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..392 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..392 /product="peptidylprolyl isomerase FPR4" /EC_number="5.2.1.8" /calculated_mol_wt="43772" Region 10..164 /region_name="NPL" /note="Nucleoplasmin-like domain; pfam17800" /db_xref="CDD:465511" Region 302..389 /region_name="FKBP_C" /note="FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254" /db_xref="CDD:459735" CDS 1..392 /gene="FPR4" /locus_tag="YLR449W" /coded_by="NM_001182337.3:1..1179" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:14981505|PMID:16959570]" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:14981505|PMID:16959570]" /experiment="EXISTENCE:direct assay:GO:0005527 macrolide binding [PMID:9371805]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14981505|PMID:9371805]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:24297734|PMID:16846601]" /experiment="EXISTENCE:mutant phenotype:GO:0043007 maintenance of rDNA [PMID:38058218]" /note="Nuclear peptidyl-prolyl cis-trans isomerase (PPIase); impacts expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; role in rDNA maintenance; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers" /db_xref="GeneID:851170" /db_xref="SGD:S000004441" ORIGIN 1 msdmlplaty slnvepyspt palnfkipvt iritmaaidp epfdddkkps tlriikrnpe 61 ltrgeyynqd nndgleedes eseqeadvpk rsvkskkgka veqsesedse deneiddefe 121 ecvlltlspk gqyqqaldit iapeedvqfv vtgsytislt gnyvkhpfdn ssdsdedeed 181 yysdeessng eeeeeeeeed deelssgddd lddlvdasdi esrldelvkk dekkknnkkd 241 skrkheedee esakpaekkq ttkkdkkaek vkdseeskpk pktklleggi iiedrvtgkg 301 phakkgtrvg mryvgklkng kvfdkntkgk pfvfklgqge vikgwdigva gmavggerri 361 vipapyaygk qalpgipans eltfdvklvs mk // LOCUS NP_013555 1045 aa linear PLN 30-JUN-2025 DEFINITION hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013555 VERSION NP_013555.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182338.1 REFERENCE 1 (residues 1 to 1045) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1045) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1045) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1045) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1045) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1045) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1045) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1045) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1045) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09750. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1045 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1045 /product="hydroxymethylglutaryl-CoA reductase (NADPH) HMG2" /EC_number="1.1.1.34" /calculated_mol_wt="115561" Region 10..159 /region_name="HPIH" /note="N-terminal domain with HPIH motif; pfam13323" /db_xref="CDD:404239" Region 195..1030 /region_name="2A060605" /note="3-hydroxy-3-methylglutaryl-coenzyme A reductase; TIGR00920" /db_xref="CDD:273339" Region 612..1021 /region_name="HMG_CoA_R_NADP" /note="3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP); TIGR00533" /db_xref="CDD:129624" Site order(656..657,662..663,668,673,676..691,703,708..715,731, 733,735,746,754,786,789,791..793,795,834,836..840,842, 844..849,851..853,860,862,864,883..884,886..895,901..904, 907..908,911,915..916,920..922,924..925,933,935,942,944, 946,958,963..964,966..967,969..970,1007) /site_type="other" /note="tetramerization interface [polypeptide binding]" /db_xref="CDD:153081" Site order(710,712..713,715..716,718..719,722,875,905,908, 1002..1003,1006,1012,1015..1016,1019) /site_type="other" /note="substrate binding pocket [chemical binding]" /db_xref="CDD:153081" Site order(710,844,920,1016) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:153081" Site order(710,713,716,888,904..905,908,1003,1007) /site_type="active" /note="inhibitor binding sites [active]" /db_xref="CDD:153081" Site order(741,777..779,802..810,812,843..844,920,955..957) /site_type="other" /note="NADP(H) binding site [chemical binding]" /db_xref="CDD:153081" CDS 1..1045 /gene="HMG2" /locus_tag="YLR450W" /coded_by="NM_001182338.1:1..3138" /experiment="EXISTENCE:direct assay:GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity [PMID:3526336]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:8744950]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8744950|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8744950]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:3526336]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /experiment="EXISTENCE:genetic interaction:GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity [PMID:2828155]" /experiment="EXISTENCE:physical interaction:GO:0000502 proteasome complex [PMID:27226596]" /note="HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; primarily expressed on the peri-membrane side of the ER; human homolog HMGCR can complement yeast hmg2 mutant" /db_xref="GeneID:851171" /db_xref="SGD:S000004442" ORIGIN 1 mslplktivh lvkpfactar fsarypihvi vvavllsaaa ylsvtqsyln ewkldsnqys 61 tylsikpdel fekcthyyrs pvsdtwklls skeaadiytp fhyylstisf qskdnsttlp 121 slddviysvd htryllseep kiptelvsen gtkwrlrnns nfildlhniy rnmvkqfsnk 181 tsefdqfdlf iilaayltlf ytlcclfndm rkigskfwls fsalsnsaca lylslytths 241 llkkpaslls lviglpfivv iigfkhkvrl aafslqkfhr isidkkitvs niiyeamfqe 301 gaylirdylf yissfigcai yarhlpglvn fcilstfmlv fdlllsatfy sailsmklei 361 niihrstvir qtleedgvvp ttadiiykde tasephflrs nvaiilgkas vigllllinl 421 yvftdklnat ilntvyfdst iyslpnfiny kdignlsnqv iisvlpkqyy tplkkyhqie 481 dsvlliidsv snairdqfis kllffafavs isinvyllna akihtgymnf qpqsnkiddl 541 vvqqksatie fsetrsmpas sgletpvtak diiiseeiqn necvyalssq depirplsnl 601 velmekeqlk nmnntevsnl vvngklplys lekkledttr avlvrrkals tlaespilvs 661 eklpfrnydy drvfgaccen vigympipvg vigpliidgt syhipmatte gclvasamrg 721 ckainaggga ttvltkdgmt rgpvvrfptl irsgackiwl dseegqnsik kafnstsrfa 781 rlqhiqtcla gdllfmrfrt ttgdamgmnm iskgveyslk qmveeygwed mevvsvsgny 841 ctdkkpaain wiegrgksvv aeatipgdvv ksvlksdvsa lvelnisknl vgsamagsvg 901 gfnahaanlv talflalgqd paqnvessnc itlmkevdgd lrisvsmpsi evgtigggtv 961 lepqgamldl lgvrgphpte pganarqlar iiacavlage lslcsalaag hlvqshmthn 1021 rktnkanelp qpsnkgppck tsall // LOCUS NP_013556 886 aa linear PLN 30-JUN-2025 DEFINITION leucine-responsive transcriptional regulator LEU3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013556 VERSION NP_013556.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182339.3 REFERENCE 1 (residues 1 to 886) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 886) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 886) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 886) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 886) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 886) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 886) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 886) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 886) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09751. On Jul 30, 2012 this sequence version replaced NP_013556.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..886 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..886 /product="leucine-responsive transcriptional regulator LEU3" /calculated_mol_wt="100023" Region 31..76 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(32,36,41..44,46,49,62) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(37,40,47,57,60,67) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 201..620 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..886 /gene="LEU3" /locus_tag="YLR451W" /coded_by="NM_001182339.3:1..2661" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:1439822]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:1439822]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:1439822]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7623798]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2183176|PMID:1439822]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2823102]" /experiment="EXISTENCE:mutant phenotype:GO:2001278 positive regulation of L-leucine biosynthetic process [PMID:2823102]" /note="Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation" /db_xref="GeneID:851172" /db_xref="SGD:S000004443" ORIGIN 1 megrsdfvat sqsgsemshs etrnrtgmna rkrkfacvec rqqkskcdah erapepctkc 61 akknvpcilk rdfrrtykra rneaiekrfk eltrtltnlt sdeilkkiee eqeivldnsn 121 ftkekvkqlr ksafetteie prsyktlrge pisystnrrh tdsspltlls sstnfdpvhs 181 tnvmtddqlk clpkslgdvy lsssdiaelf qefatkyhqf lpvvdlskga eriyhlspcl 241 fwvilliglr rkfgatdlmt rlsvlvksvl seitispiir ytpsdkdepv lnvasvysvq 301 afllytfwpp ltsslsadts wntigtamfq alrvglncag fskeyasans elvneqirtw 361 iccnvvsqtv assfgfpayv sfdylvissi rvpnsksqvd ipnelrqmaq iarfenqivn 421 tmnstpasvt gmvsqeekqp llhvlnqqls qleisleenn lddirkflll vakvhlltyy 481 ftdvtsqsag ksngniyegs ysimeldtsf etkrglvkvy naavnfliha nsmwehdpti 541 ikyfpglfvl niwqsaciis klihsslhsm ldvnsgkkay nnaisltfna svlkydmayr 601 ssgimrsiws lfanmydawk ndqkegggrl nndfnlgiti ksrmsvnvff dclyilkekc 661 gmakleretk vstaynvdee eeededeege eeeeeeelss kvpenmdsqq lrtrkftnvr 721 hpekkarkii etipldpnpi nagstssgss lttpnsqvan tisyrgilnk mspreqlnha 781 nldssvstdi kdteavnepl pigrnaehpa nqpplsitqm qentlpatqa nsslletypi 841 vqsnpvttti kespnsimag wdnwesdmvw rdvdilmnef afnpkv // LOCUS NP_013557 698 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein SST2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013557 VERSION NP_013557.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182340.1 REFERENCE 1 (residues 1 to 698) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 698) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 698) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 698) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 698) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09752. Method: conceptual translation. FEATURES Location/Qualifiers source 1..698 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..698 /product="GTPase-activating protein SST2" /calculated_mol_wt="79586" Region 57..135 /region_name="DEP" /note="DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; cl02442" /db_xref="CDD:470580" Region 265..353 /region_name="DEP_RGS7-like" /note="DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain; cd04450" /db_xref="CDD:239897" Region 420..>537 /region_name="RGS" /note="Regulator of G protein signaling (RGS) domain superfamily; cl02565" /db_xref="CDD:470619" CDS 1..698 /gene="SST2" /locus_tag="YLR452C" /gene_synonym="SSL2" /coded_by="NM_001182340.1:1..2097" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:9537998]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8756677]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:2830483]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:9537998]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:2830483]" /note="GTPase-activating protein for Gpa1p; regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family" /db_xref="GeneID:851173" /db_xref="SGD:S000004444" ORIGIN 1 mvdknrtlhe lssknfsrtp ngliftndlk tvysiflicl dlkekkhssd tksflltaft 61 khfhftftyq eaikamgqle lkvdmnttci nvsynikpsl arhlltlfms skllhtpqdr 121 trgepkekvl fqptpkgvav lqkyvrdigl ktmpdillss fnsmklftfe rssvtdsiih 181 sdylihilfi kmmgakpnvw sptnaddplp clsslleytn nddtftfeks kpeqgwqaqi 241 gnidindler vsplahrfft npdseshtqy yvsnagirlf enktfgtskk ivikytfttk 301 aiwqwimdct dimhvkeavs laalflktgl ivpvllqpsr tdkkkfqisr ssfftlskrg 361 wdlvswtgck snnirapngs tidldftlrg hmtvrdekkt lddsegfsqd mlisssnlnk 421 ldyvltdpgm rylfrrhlek elcvenldvf ieikrflkkm tilkklidsk hcdkksntst 481 sknnivktid salmkqanec lemayhiyss yimigspyql nihhnlrqni sdimlhphsp 541 lsehfptnly dpspasaesa assisstead tlgeppevsl kpsknlsnen csfkkqgfkh 601 qlkeykpapl tlaethspna svenshtivr ygmdntqndt ksvesfpatl kvlrklyplf 661 eivsnemyrl mnndsfqkft qsdvykdasa lieiqekc // LOCUS NP_013558 395 aa linear PLN 30-JUN-2025 DEFINITION Rif2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013558 VERSION NP_013558.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182341.3 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09753. On Jul 30, 2012 this sequence version replaced NP_013558.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..395 /product="Rif2p" /calculated_mol_wt="45512" CDS 1..395 /gene="RIF2" /locus_tag="YLR453C" /coded_by="NM_001182341.3:1..1188" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:9710643]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:17656141|PMID:9710643]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:9087429]" /experiment="EXISTENCE:mutant phenotype:GO:0016233 telomere capping [PMID:20523746]" /experiment="EXISTENCE:physical interaction:GO:0070187 shelterin complex [PMID:23746845]" /note="Protein that binds to the Rap1p C-terminus; inhibits MRX-dependent Tel1p activity by acting directly on Rad50p and discharging its activated ATP-bound state, thereby rendering the MRX complex incompetent for Tel1p activation; acts synergistically with Rif1p to help control telomere length, establish telomeric silencing; deletion results in telomere elongation; RIF2 has paralog ORC4 that arose from the whole genome duplication" /db_xref="GeneID:851174" /db_xref="SGD:S000004445" ORIGIN 1 mehvdsdfap irrskkvvds dkivkaisdd leqknftvlr klnlvpikks vsspkvckps 61 pvkervdhvf yqkfksmalq elgtnylsis yvpslskfls knlrsmknci vffdkvehih 121 qyagidravs etlslvdinv viiemndylm kegiqssksk eciesmgqas ysgqldfeas 181 ekpsnhtsdl mmmvmrkinn desidhivyf kfeqldklst stiiepsklt efinvlsvle 241 ksnniafkvl iysnnvsiss llstslkkkl ntkytvfemp iltcaqeqey lkkmikftfd 301 sgskllqsyn slvtcqlnnk esnlaiffef lkvfphpfty lfnayteiiv qsrtfdelld 361 kirnrltikn yphsaynfkk nqrlplkltr kvhdr // LOCUS NP_013559 2628 aa linear PLN 30-JUN-2025 DEFINITION Fmp27p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013559 VERSION NP_013559.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182342.1 REFERENCE 1 (residues 1 to 2628) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2628) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 2628) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2628) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 2628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 2628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 2628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09754. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2628 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..2628 /product="Fmp27p" /calculated_mol_wt="303350" Region 26..921 /region_name="Fmp27" /note="Mitochondrial protein from FMP27; pfam10344" /db_xref="CDD:431223" Region 938..1100 /region_name="DUF2405" /note="Domain of unknown function (DUF2405); pfam10293" /db_xref="CDD:431201" Region 1178..1278 /region_name="Fmp27_SW" /note="RNA pol II promoter Fmp27 protein domain; pfam10305" /db_xref="CDD:431207" Region 1298..1456 /region_name="Fmp27_GFWDK" /note="RNA pol II promoter Fmp27 protein domain; pfam10347" /db_xref="CDD:402113" Region 1717..2173 /region_name="Fmp27_WPPW" /note="RNA pol II promoter Fmp27 protein domain; pfam10359" /db_xref="CDD:431231" Region 2185..2588 /region_name="Apt1" /note="Golgi-body localization protein domain; pfam10351" /db_xref="CDD:463055" CDS 1..2628 /gene="FMP27" /locus_tag="YLR454W" /gene_synonym="HOB1" /coded_by="NM_001182342.1:1..7887" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:37366411]" /note="Protein with structural similarity to lipid transport protein Vps13p; localizes to multiple membrane contact sites between organelles including mitochondria-ER contact sites; non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:851175" /db_xref="SGD:S000004446" ORIGIN 1 mmfpinvlly kwlifavtfl wsckillrkl lginitwinl fkleicglsl edgtvrlksv 61 rfavferklf ikglridskk sstndlhkel preeertfie tpedngggfi skilslsqyw 121 lngvtiiled tqlvnnditi ekfgfflsid nskhikslrf dsflrkllwn gqtiiadaif 181 ivntnllige imnplkdglq vgldlklgdl nipmnllnlf inkenvdlms nekllqrlad 241 ttkaneelkd ediakmkddl vyamekfvdr ikplkemnvt vdklqikdfp ltnhpellgm 301 nkyisynvlv sninfntnrf rnempgytli feerdspfkf siimarfniy lnlnrkhqsh 361 akqlkiieip nvsifgetnl fsqkfrlsnn lhakelenai fnikgnissl tidmdpvnis 421 fikcflsnik vftsscpknk ilkenshvkf ltrrrvlfdy fkcflplinm kftlddpkfv 481 indkddliig kfsvfmishh skrytlgnnl meekeetqhi fyeshwnvel ldmklqhiik 541 hqkyehtilr vdsiaieekv qllpdilcsa nadidtlmld lselptmvml selvhnldsq 601 lanveenyfk efyekfasnl qnmkaecsnm akclrqkeil psdfmfqqlp dffdyikini 661 rdisstlgar svfmprdvfs svdsqsskdl idgklrkycn tveklqialf gdktqwhnki 721 gsnhatmvrs gqltnfskdn kqnpnhkssi adlddistsd atevnhlwni nllvnditts 781 iigetpevse elstktvskv snlsiklfpd tesfssnesd skiilqinhs rgtsvvslms 841 iflavsgiht lnqifghcih qkmrqsktkq yflalseskk ksciksikwg qlkelleinf 901 sseyisqiia lpnglrtkfe ptstfitvkn cntisvsgqy frmmvesptq pnfwermici 961 ngfkvmihid llkqqmkkln slqnweklps aitlendswh fsiphhfemf kiidsiptif 1021 ksikqmlysl ktskddliif phkietplsl pkiklkskrw lfsisddple aelntifqig 1081 lqeqrerlak lqefnkrise dliksqknak emkddfeaid nailkhrtgl wakdgkkrlr 1141 ksatdseipl tpaalningk rddrpdrtqf ispeienayn tllanfsdsw ikrvkeykvk 1201 errefdknfs flwgfidytk lpkdinkkvl pfstnpflmn liienididi irpscgieni 1261 pnfihdvgkg vpknteysim ipmhldakfs evrwhlrdyp lpfvsippls stqsketipm 1321 riygdfmite dmlqsdrelr tlfvplipsv tventdryys lfvprtmtsa kiftdlnfei 1381 nsnhttrvtw ggsyqpaiqq tmqcldnfsk ppldpsvklg fwdktrylfh gkinivwkkr 1441 gkfeislkga kspymlgges agfivgfdgn vnlkcnednd pkkflscsad kvhfsipnyf 1501 akpllvwsrp stntmfipnq ddtnmqryas fyyllnttss knekadkeim gksfiektgi 1561 klsggmtldm gilferlgps lnertfeskk hyltrlcnpi yvqdlskhds yagfrsdfih 1621 msfglssnsn saynamqlsp ngfkaffvww ksfsgnfpvr rgplfglqsi spkfgehlyt 1681 isyhadvspl finymyhnad adqilrknyl evaefaglka ksshfimdlh qrkevlteyq 1741 aglnvrrrvm klkflagdvv cqdvdirtvs gefsklnyie ekedaeydif dndmswldit 1801 dfqdaffinp dnylpkikim pfafspqfay qkrasygdky qvdpktckpi tpfdnrvshg 1861 ctlghnvslr tdlvekrvtv lkkfreklqe girknksagv seenlndlls kanssvenae 1921 lllkdfqkif kqheagqteq pfhfdslnll kntkktlkqf ehrffifnvl lkwnedarsa 1981 ifkffyyanl snefaslasg kglrefedvi kqremtddtt smeaipegtd kanttkqchs 2041 cddteftten llnifeknit qlscdiknki hhkffvqfit pqiqltslen peacvlvssp 2101 ffmlktlefd anttsntymq diflkrhgil fgnanaflfn kkdyqeffel yfgsssygqd 2161 kkeqwppwlg lelgfepsal kkkavvrnis allhhqklap fsakydslkd kiednicgyv 2221 pqvnvqvnsd eylmltkmal klflyveped eelkkyiekl iigydiydta qtrkfvndlh 2281 dseqilavve kellfkrsll ddigkldlsn ihnermhqll rlyilrkvft sngnnyinrt 2341 lvwnikvnet ilhlldkidk pfldiavakl nfqriqhtmg lrkntvtvkm mqifdlgenv 2401 nyhcilgpli tssgndtvgl asdvplvqit wdvdkpvggi kvvknvettl ssltikleed 2461 rlnklfewls lkeliydgng ddddgassif dmvsseseeg kiefsediss dfnemlkrss 2521 dymivedlkl nsfklcisyk gkgkmrlanv tnfvfnfptl rlsnqtlrvt dlllalkkvl 2581 ikvlikhtgr fignklkrns kenkiaddts plkqlttyns ytepeelr // LOCUS NP_013560 304 aa linear PLN 30-JUN-2025 DEFINITION Pdp3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013560 VERSION NP_013560.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182343.3 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09755. On Jul 30, 2012 this sequence version replaced NP_013560.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..304 /product="Pdp3p" /calculated_mol_wt="35377" Region 8..95 /region_name="PWWP_ScIOC4-like" /note="PWWP domain found in Saccharomyces cerevisiae ISWI one complex protein 4 (ScIOC4) and similar proteins; cd05840" /db_xref="CDD:438965" Site order(18,21,48) /site_type="other" /note="putative methyl-histone binding site [polypeptide binding]" /db_xref="CDD:438965" Site 19..22 /site_type="other" /note="PWWP sequence motif" /db_xref="CDD:438965" CDS 1..304 /gene="PDP3" /locus_tag="YLR455W" /coded_by="NM_001182343.3:1..915" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:35273076]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:25104842]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:35273076]" /experiment="EXISTENCE:direct assay:GO:0033100 NuA3 histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:direct assay:GO:1990468 NuA3b histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:25104842]" /note="Component of the NuA3b histone acetyltransferase complex; binds to Pol II and stimulates elongation; regulates interaction between NuA3b and H3K36me3 at transcribed regions of genes; contains PWWP domain; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia; extensive sequence similarity (; 25% identity; 39% similarity) to the N-terminal region of human NDF" /db_xref="GeneID:851177" /db_xref="SGD:S000004447" ORIGIN 1 mtkdirtgdl vlckvgsfpp wpavvfpqrl lrndvyrkrk sncvavcffn dptyyweqps 61 rlkeldqdsi hnfilehskn anqrelvnay keaknfddfn vflqekfeee nrlsdlkafe 121 ksegskivag edpfvgrtkv vnkrkknsis ikedpednqk sneeeskpni kpskkkrpta 181 nsggksnsgn kkkvkldysr rveisqlfrr riqrnliqre tppteheike thellnriye 241 nsdtkrpffd lkalresklh kllkaivndp dlgefhplck eillswadli telkkeklqa 301 lptp // LOCUS NP_013561 204 aa linear PLN 30-JUN-2025 DEFINITION pyridoxal 5'-phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013561 VERSION NP_013561.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182344.1 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09756. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..204 /product="pyridoxal 5'-phosphate synthase" /calculated_mol_wt="23162" Region 7..>90 /region_name="Putative_PNPOx" /note="Pyridoxamine 5'-phosphate oxidase; pfam01243" /db_xref="CDD:426149" CDS 1..204 /locus_tag="YLR456W" /coded_by="NM_001182344.1:1..615" /note="hypothetical protein; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2; YLR456W has a paralog, YPR172W, that arose from the whole genome duplication" /db_xref="GeneID:851178" /db_xref="SGD:S000004448" ORIGIN 1 mklneqipkd llrlikssky vhvatcssnc ipsvslmhyi fvssaetfhk heysieidcn 61 dyiiftvfek svtfrnvmsn pnvallfhdw itaknltlrk ksvhskddfs fvesestkfn 121 nflrdlnqse lnqvsating iadivnpnse estyyrrlll tvnpdadifi lgedtaiikv 181 niqkikvsdm enntstygqt vqpv // LOCUS NP_013562 319 aa linear PLN 30-JUN-2025 DEFINITION Nbp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013562 VERSION NP_013562.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182345.3 REFERENCE 1 (residues 1 to 319) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 319) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 319) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 319) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09757. On Jul 30, 2012 this sequence version replaced NP_013562.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..319 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..319 /product="Nbp1p" /calculated_mol_wt="37223" Region 1..319 /region_name="NBP1" /note="Fungal Nap binding protein NBP1; pfam08537" /db_xref="CDD:400720" CDS 1..319 /gene="NBP1" /locus_tag="YLR457C" /coded_by="NM_001182345.3:1..960" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:21785410]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:21785410|PMID:16436507]" /experiment="EXISTENCE:direct assay:GO:0005823 central plaque of spindle pole body [PMID:16436507]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:21785410]" /experiment="EXISTENCE:genetic interaction:GO:0030474 spindle pole body duplication [PMID:16436507]" /experiment="EXISTENCE:mutant phenotype:GO:0005637 nuclear inner membrane [PMID:21785410]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:16436507]" /experiment="EXISTENCE:mutant phenotype:GO:0070631 spindle pole body localization [PMID:21785410]" /experiment="EXISTENCE:physical interaction:GO:0030474 spindle pole body duplication [PMID:16436507]" /note="Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication" /db_xref="GeneID:851180" /db_xref="SGD:S000004449" ORIGIN 1 mlksvqglwk dffgirddgr kreygsldev rkrsalrsrr kqmrptgksv lkrprkvtdr 61 kteekirtnr rktpkrrltk ifqtirdvfs ndnenmskmq nvcgdmtril kkrsqgrpsy 121 mdtdtaksri lrsdafkrki selkynkqri selrsgssdg ssgkdrnqsl yldreillqr 181 qikkrdekik alesklqslq ealnysneky riledlldss nihpsytksr rtmsnlaren 241 deikplkidl spspirrtns lftsspmkty nrdgnipemq plqenispac ptppyrsret 301 ekedetlspi svdfssyls // LOCUS NP_013564 394 aa linear PLN 30-JUN-2025 DEFINITION GPI-anchor transamidase subunit GAB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013564 VERSION NP_013564.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182347.1 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09758. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..394 /product="GPI-anchor transamidase subunit GAB1" /calculated_mol_wt="44610" Region 10..360 /region_name="PIG-U" /note="GPI transamidase subunit PIG-U; pfam06728" /db_xref="CDD:429085" CDS 1..394 /gene="GAB1" /locus_tag="YLR459W" /gene_synonym="CDC91" /coded_by="NM_001182347.1:1..1185" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0016255 attachment of GPI anchor to protein [PMID:15075373]" /experiment="EXISTENCE:mutant phenotype:GO:0042765 GPI-anchor transamidase complex [PMID:15075373]" /experiment="EXISTENCE:physical interaction:GO:0042765 GPI-anchor transamidase complex [PMID:15075373]" /note="Subunit of the glycosylphosphatidylinositol transamidase complex; involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or the lipid portion of GPI; ortholog of human PIGU; partially complements a class U CHO cell line with a mutation in the PIGU ortholog" /db_xref="GeneID:851181" /db_xref="SGD:S000004451" ORIGIN 1 mdstalkval gciairlavn slfpslqqql dqsvefstpv tsfrslqegi yllrnniqvy 61 nhgvvhhppi lifflslfns drlisliyal idgliayqlt evtkafknlk lkvwlpglly 121 avnpltllsc isrssiiftn faissslyci laegnvllss vmisisgyls vypilllipl 181 lgmlkswrqr ilsaivsils llilllfsys ilgsqswsfl tqvygsiitf ekvfpnlglw 241 wyffiemfdt fipffkavfn ifiavfitpf tlryhkqpfy afilcigwiv ltkpypslgd 301 agfffsflpf ftplfgylry piisallflh aivlapifyh lwvvlgsgns nffyaislvy 361 alaiasilvd lnwamlriey dngipnfklk vtqi // LOCUS NP_013565 376 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR460C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013565 VERSION NP_013565.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182348.3 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09759. On Jul 30, 2012 this sequence version replaced NP_013565.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..376 /product="uncharacterized protein" /calculated_mol_wt="40996" Region 9..375 /region_name="enoyl_reductase_like" /note="cd08249" /db_xref="CDD:176211" Site order(46..47,152,184..187,208..209,211..212,227,249..250, 274..275,296,298,367..368) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:176211" CDS 1..376 /locus_tag="YLR460C" /coded_by="NM_001182348.3:1..1131" /note="Member of the quinone oxidoreductase family; up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine" /db_xref="GeneID:851182" /db_xref="SGD:S000004452" ORIGIN 1 mqvaipetmk avviedgkav vkegipipel eegfvliktl avagnptdwa hidykigpqg 61 silgcdaagq ivklgpavnp kdfsigdyiy gfihgssvrf psngafaeys aistvvayks 121 pnelkflged vlpagpvrsl egvatipvsl ttaglvltyn lgldlkweps tpqrkgpill 181 wggatavgqs liqlanklng ftkiivvasr khekllkeyg adelfdyhdi dvveqikhky 241 nnisylvdcv anqdtlqqvy kcaadkqdat ivelknltee nvkkenrrqn vtidiirlys 301 igghevpfgn itlpadsear kaaikfikfi npkindgqir hipvrvykng lcdvphilkd 361 ikygknsgek lvavln // LOCUS NP_013566 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013566 VERSION NP_013566.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182349.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09760. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..120 /product="seripauperin PAU4" /calculated_mol_wt="12760" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU4" /locus_tag="YLR461W" /coded_by="NM_001182349.1:1..363" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme" /db_xref="GeneID:851183" /db_xref="SGD:S000004453" ORIGIN 1 mvkltsiaag vaaiaatasa tttiaqsder vnlvelgvyv sdirahlaqy ymfqaahpte 61 typvevaeav fnygdfttml tgiapdqvtr mitgvpwyss rlkpaiskal skdgiytian // LOCUS NP_013567 202 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR462W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013567 VERSION NP_013567.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182350.3 REFERENCE 1 (residues 1 to 202) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 202) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 202) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 202) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09761. On Jul 30, 2012 this sequence version replaced NP_013567.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..202 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..202 /product="uncharacterized protein" /calculated_mol_wt="23363" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" CDS 1..202 /locus_tag="YLR462W" /coded_by="NM_001182350.3:1..609" /note="hypothetical protein with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII" /db_xref="GeneID:851184" /db_xref="SGD:S000004454" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekvvisvmv gknvkkfltf vedepdfqgg pipskylvpk kinlmvytlf 121 qvhtlkfnrk dydtlslfyl nrgyynelsf rvlercheia sarpndsstm rtftdfvsga 181 pivrslqkst irkygynlaa yt // LOCUS NP_013569 216 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YLR464W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013569 VERSION NP_013569.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182352.1 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09762. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..216 /product="uncharacterized protein" /calculated_mol_wt="24040" CDS 1..216 /locus_tag="YLR464W" /coded_by="NM_001182352.1:1..651" /note="hypothetical protein; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C" /db_xref="GeneID:851185" /db_xref="SGD:S000004456" ORIGIN 1 mqaslpgekk vdterlkrdl cprkpieiky fsqicndmmn kkdrlgdilh iilracalnf 61 gagprggagd eedrsitnee piipsvdehg lkvcklrspn tprrlrktld avkallvssc 121 actardldif ddnngvamwk wikilyheva qettlkdsyr itlvpssdgi sdtltviqsf 181 sysllpvlsa tytsmiqqda snctlittrt vhrsld // LOCUS NP_013571 1382 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase protein 1 copy 4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013571 VERSION NP_013571.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182354.3 REFERENCE 1 (residues 1 to 1382) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1382) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1382) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1382) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09763. On Jul 30, 2012 this sequence version replaced NP_013571.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1382 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1382 /product="Y' element ATP-dependent helicase protein 1 copy 4" /EC_number="3.6.4.12" /calculated_mol_wt="156237" Region 376..548 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" Region 623..718 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1382 /gene="YRF1-4" /locus_tag="YLR466W" /gene_synonym="YRF1" /coded_by="NM_001182354.3:1..4149" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9837911]" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:9837911]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]" /note="Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" /db_xref="GeneID:851187" /db_xref="SGD:S000004458" ORIGIN 1 mwktlgrveq llpyaslilr nrevlfrepk rgideylend sffqmipvky reivlpklrr 61 dtnkmtaalk nkvavaidel tvplmwmihf avgypyrype lqllafagpq rnvyvddttr 121 riqlytdynk ngsseprlkt ldgltsdyvf yfvtvlrqmq icalgnsyda fnhdpwmdvv 181 gfedpdqvtn rdisrivlys ymflntakgc lveyatfrqy mrelpknapq klnfremrqg 241 lialgrhcvg srfetdlyes atselmanhs vqtgrniygv dsfsltsvsg ttatllqera 301 serwiqwlgl esdyhcsfss trnaedvvag eaassdhhqk isrvtrkrpr epkstndilv 361 agrklfgssf efrdlhqlrl cheiymadtp svavqappgy gktelfhlpl ialaskgdvk 421 yvsflfvpyt vllancmirl srcgclnvap vrnfieegcd gvtdlyvgiy ddlastnftd 481 riaawenive ctfrtnnvkl gylivdefhn fetevyrqsq fggitnldfd afekaiflsg 541 tapeavadaa lqrigltgla kksmdinelk rsedlsrgls syptrmfnli keksevplgh 601 vhkiwkkves qpeealklll alfeiepesk aivvasttne veelacswrk yfrvvwihgk 661 lgaaekvsrt kefvtdgsmr vligtklvte gidikqlmmv imldnrlnii eliqgvgrlr 721 dgglcyllsr knswaarnrk gelppikegc iteqvrefyg leskkgkkgq hvgccgsrtd 781 lsadtvelie rmdrlaekqa tasmsiialp ssfqesnssd rcrkycssde dsdtcihgsa 841 nastnattns stnatttast nvrtsattta sinvrtsait testnsstna tttastnvrt 901 satttasinv rtsatttest nsntsattte stdsntsatt testdsntsa tttastnsst 961 natttastns stnatttest nasakedank dgnaednrfh pvtdinkesy krkgsqmvll 1021 erkklkaqfp ntsenmnvlq flgfrsdeik hlflygidvy fcpegvftqy glckgcqkmf 1081 elcvcwagqk vsyrrmawea lavermlrnd eeykeyledi epyhgdpvgy lkyfsvkrge 1141 iysqiqrnya wylaitrrre tisvldstrg kqgsqvfrms grqikelyyk vwsnlreskt 1201 evlqyflnwd ekkcreewea kddtvfveal ekvgvfqrlr smtsaglqgp qyvklqfsrh 1261 hrqlrsryel slgmhlrdql algvtpskvp hwtaflsmli glfynktfrq kleylleqis 1321 evwllphwld lanvevlaad ntrvplymlm vavhkeldsd dvpdgrfdii llcrdssrev 1381 ge // LOCUS NP_013572 1796 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase protein 1 copy 5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013572 VERSION NP_013572.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182355.3 REFERENCE 1 (residues 1 to 1796) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1796) AUTHORS Johnston,M., Hillier,L., Riles,L., Albermann,K., Andre,B., Ansorge,W., Benes,V., Bruckner,M., Delius,H., Dubois,E., Dusterhoft,A., Entian,K.D., Floeth,M., Goffeau,A., Hebling,U., Heumann,K., Heuss-Neitzel,D., Hilbert,H., Hilger,F., Kleine,K., Kotter,P., Louis,E.J., Messenguy,F., Mewes,H.W., Hoheisel,J.D. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XII JOURNAL Nature 387 (6632 SUPPL), 87-90 (1997) PUBMED 9169871 REFERENCE 3 (residues 1 to 1796) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1796) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (06-FEB-2013) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Protein update by submitter REFERENCE 8 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA, USA REMARK Sequence update by submitter REFERENCE 9 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09765. On Jul 30, 2012 this sequence version replaced NP_013572.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1796 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XII" Protein 1..1796 /product="Y' element ATP-dependent helicase protein 1 copy 5" /EC_number="3.6.4.12" /calculated_mol_wt="203651" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 790..962 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" Region 1037..1132 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1796 /gene="YRF1-5" /locus_tag="YLR467W" /gene_synonym="YRF1" /coded_by="NM_001182355.3:1..5391" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9837911]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]" /note="Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" /db_xref="GeneID:851189" /db_xref="SGD:S000004459" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekivisvmv gknvqkfltf vedepdfqgg pipskylipk kinlmvytlf 121 qvhtlkfnrk dydtlslfyl nrgyynelsf rvlercheia sarpndsstm rtftdfvsga 181 pivrslqkst irkygynlap ymflllhvde lsifsayqas lpgekkvdte rlkrdlcprk 241 pieikyfsqi cndmmnkkdr lgdilhiilr acalnfgagp rggagdeedr sitneepiip 301 svdehglkvc klrspntprr lrktldavka llvsscacta rdldifddtn gvamwkwiki 361 lyhevaqett lkdsyritlv pssdgisvcg klfnreyvrg fyfackaqfd nlwgelnncf 421 ymptvvdias lilrnrevlf repkrgidey lendsflqmi pvkyreivlp klrrdtnkmt 481 aalknkvtva ideltvplmw mvhfavgypy rypelqllaf agpqrnvyvd dttrriqlyt 541 dynkngssep rlktldglts dyvfyfvtvl rqmqicalgn sydafnhdpw mdvvgfedpd 601 qvtnrdisri vlysymflnt akgclveyat frqymrelpk napqklnfre mrqglialgr 661 hcvgsrfetd lyesatselm anhsvqtgrn iygvdsfslt svsgttatll qeraserwiq 721 wlglesdyhc sfsstrnaed vvageaassd hdqkisrvtr krprepkstn dilvagqklf 781 gssfefrdlh qlrlcheiym adtpsvavqa ppgygktelf hlplialask gdvkyvsflf 841 vpytvllanc mirlsrcgcl nvapvrnfie egcdgvtdly vgiyddlast nftdriaawe 901 nivectfrtn nvklgylivd efhnfetevy rqsqfggitn ldfdafekai flsgtapeav 961 adaalqrigl tglakksmdi nelkrsedls rglssyptrm fnlikeksev plghvhkiwk 1021 kvesqpeeal klllalfeie peskaivvas ttneveelac swrkyfrvvw ihgklgaaek 1081 vsrtkefvtd gsmrvligtk lvtegidikq lmmvimldnr lniieliqgv grlrdgglcy 1141 llsrknswaa rnrkgelppi kegciteqvr efygleskkg kkgqhvgccg srtdlsadtv 1201 eliermdrla ekqatasmsi ialpssfqes nssdrcrkyc ssdedsdtci hgsanastna 1261 ttnsstnatt tastnvrtsa tttasinvrt saittestns stnatttast nvrtsattta 1321 sinvrtsatt testnsntsa tttestdsnt satttestds ntsatttast nsstnattta 1381 stnsstnatt testnasake dankdgnaed nrfhpvtdin kesykrkgsq mvllerkklk 1441 aqfpntsenm nvlqflgfrs deikhlflyg idvyfcpegv ftqyglckgc qkmfelcvcw 1501 agqkvsyrrm awealaverm lrndeeykey lediepyhgd pvgylkyfsv krgeiysqiq 1561 rnyawylait rrretisvld strgkqgsqv frmsgrqike lyykvwsnlr esktevlqyf 1621 lnwdekkcre eweakddtvf vealekvgvf qrlrsmtsag lqgpqyvklq fsrhhrqlrs 1681 ryelslgmhl rdqlalgvtp skvphwtafl smliglfynk tfrqkleyll eqisevwllp 1741 hwldlanvev laadntrvpl ymlmvavhke ldsddvpdgr fdiillcrds srevge // LOCUS NP_013573 1374 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013573 VERSION NP_013573.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182496.1 REFERENCE 1 (residues 1 to 1374) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1374) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1374) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1374) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09766. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1374 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1374 /product="Y' element ATP-dependent helicase" /EC_number="3.6.4.12" /calculated_mol_wt="155423" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 368..540 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" Region 615..710 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1374 /locus_tag="YML133C" /coded_by="NM_001182496.1:1..4125" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="Putative Y' element ATP-dependent helicase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron" /db_xref="GeneID:854906" /db_xref="SGD:S000004602" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekivvsvmv gknvqkfltf vedepdfqgg pipskylipk kinlmvytlf 121 qvhtlkfnrk dydtlslfyl nrgyynelsf rvlercheia sarpndsstm rtftdfvsga 181 pivrslqkst irrygynlap hmflllhvde lsifsayqas lpgekkvdte rlkrdlcprk 241 pieikyfsqi cndmmnkkdr lgdvlataqr irrrynknss seprlktldg ltserwiqwl 301 glesdyhcsf sstrnaedvv ageaassdhh qkisrvtrkr prepkstndi lvagqklfgs 361 sfefrdlhql rlcheiymad tpsvavqapp gygktelfhl plialaskgd vkyvsflfvp 421 ytvllancmi rlsrcgclnv apvrnfieeg cdgvtdlyvg iyddlastnf tdriaaweni 481 vectfrtnnv klgylivdef hnfetevyrq sqfggitnld fdafekaifl sgtapeavad 541 aalqrigltg lakksmdine lkrsedlsrg lssyptrmfn likeksevpl ghvhkiwkkv 601 esqpeealkl llalfeiepe skaivvastt neveelacsw rkyfrvvwih gklgaaekvs 661 rtkefvtdgs mrvligtklv tegidikqlm mvimldnrln iieliqgvgr lrdgglcyll 721 srknswaarn rkgelppike gciteqvref ygleskkgkk gqhvgccgsr tdlsadtvel 781 iermdrlaek qatasmsiva lpssfqesns sdrcrkycss dedsdtcihg sanastnatt 841 nsstnattta stnvrtsatt tasinvrtsa tttestnsst natttastnv rtsatttasi 901 nvrtsattte stnsntsatt testdsntsa tttestdsnt satttastns stnatttast 961 nsstnattte stnasakeda nkdgnaednr fhpvtdinke sykrkgsqmv llerkklkaq 1021 fpntsenmnv lqflgfrsde ikhlflygid iyfcpegvft qyglckgcqk mfelcvcwag 1081 qkvsyrrmaw ealavermlr ndeeykeyle diepyhgdpv gylkffsvkr geiysqiqrn 1141 yawylaitrr retisvldst rgkqgsqvfr msgrqikely ykvwsnlres ktevlqyfln 1201 wdekkcreew eakddtvfve alekvgvfqr lrsmtsaglq gpqyvklqfs rhhrqlrsry 1261 elslgmhlrd qlalgvtpsk vphwtaflsm liglfynktf rqkleylleq isevwllphw 1321 vdlanvevla adntrvplym lmvavhkeld sddvpdgrfd iillcrdssr evge // LOCUS NP_013574 379 aa linear PLN 30-JUN-2025 DEFINITION Cos3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013574 VERSION NP_013574.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182495.1 REFERENCE 1 (residues 1 to 379) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 379) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 379) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 379) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09767. Method: conceptual translation. FEATURES Location/Qualifiers source 1..379 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..379 /product="Cos3p" /calculated_mol_wt="45034" Region 73..167 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 262..351 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..379 /gene="COS3" /locus_tag="YML132W" /coded_by="NM_001182495.1:1..1140" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14718542|PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:25942624]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:14718542]" /experiment="EXISTENCE:mutant phenotype:GO:0006883 intracellular sodium ion homeostasis [PMID:14718542]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /db_xref="GeneID:854907" /db_xref="SGD:S000004601" ORIGIN 1 mkenelknek svdvlsfkql esqkivlpqd lfrssftwfc yeiykslafr iwmllwlpls 61 vwwklsnnci yplivsllvl flgpifvlvi cglsrkrsls kqliqfckei tentpssdph 121 dwevvaanln sylyennvwn tkyfffnamv cqeafrttll epfslkkdka akvksfkdsv 181 pyieealgvy ftevekqwkl fntekswspv gledaklpke ayrfkltwfl krisnifmli 241 pflnflcciy vsrgmclllr tlylgwilfm lvqgfqnirv limsmehkmq flstiineqe 301 sgangwdeia rkmnrylfek kawkneefff dgidcewffn hffyrvlsak ksmwplplnv 361 elwpyikeaq lsrsevllv // LOCUS NP_013575 365 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML131W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013575 VERSION NP_013575.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182494.1 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09768. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..365 /product="uncharacterized protein" /calculated_mol_wt="39845" Region 4..359 /region_name="PGDH" /note="Prostaglandin dehydrogenases; cd05288" /db_xref="CDD:176190" Site order(58,143,147,176..178,199..200,204,220,245..246, 267..271,273,297..299,348..349,351,353) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:176190" Site order(59,273,300) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:176190" Site order(62,66,261,266..269,272,287..288,291..298,301) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:176190" CDS 1..365 /locus_tag="YML131W" /coded_by="NM_001182494.1:1..1098" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; similar to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854908" /db_xref="SGD:S000004600" ORIGIN 1 mvlakqwvlk nlptpgepfn fhfhdpactf eliekelsse qlkdgellle ttylsndpaq 61 kfwissmdkn yakgvqpgei ipargigkvl asrnkafspg dyvsavtgwt thaiisqenv 121 qglrkldknk vgklwwylsv lggtsltayf ifftyaqlqe reedygkvyl isgaagavgt 181 vciqlalnvf kaskviaiag gpekvafves fgdnvvgvdy kdpsfkqkli eaaggentvd 241 yfidnvgsnv leagvlllkq ramliacgai sayndpskfv fkgysfiltk rlvvkgvlvt 301 dniddfpkal dklgslvkhg kidllksatl edgtgdkfkn vpliwkglfs gvnkgklitk 361 vnnee // LOCUS NP_013576 563 aa linear PLN 30-JUN-2025 DEFINITION ER oxidoreductin [Saccharomyces cerevisiae S288C]. ACCESSION NP_013576 VERSION NP_013576.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182493.1 REFERENCE 1 (residues 1 to 563) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 563) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 563) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 563) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 563) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09769. Method: conceptual translation. FEATURES Location/Qualifiers source 1..563 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..563 /product="ER oxidoreductin" /calculated_mol_wt="64902" Region 8..526 /region_name="ERO1" /note="Oxidoreductin, endoplasmic reticulum membrane-associated protein involved in disulfide bond formation [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; COG5061" /db_xref="CDD:227393" CDS 1..563 /gene="ERO1" /locus_tag="YML130C" /coded_by="NM_001182493.1:1..1692" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:9659914]" /experiment="EXISTENCE:direct assay:GO:0016972 thiol oxidase activity [PMID:16407158]" /experiment="EXISTENCE:mutant phenotype:GO:0034975 protein folding in endoplasmic reticulum [PMID:9659913]" /note="Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining ER redox balance; feedback regulated via reduction and oxidation of regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds; ero1-1 mutation complemented by human ERO1L" /db_xref="GeneID:854909" /db_xref="SGD:S000004599" ORIGIN 1 mrlrtaiatl cltaftsats nnsyiatdqt qnafndthfc kvdrndhvsp scnvtfneln 61 ainenirddl sallksdffk yfrldlykqc sfwdandglc lnracsvdvv edwdtlpeyw 121 qpeilgsfnn dtmkeaddsd deckfldqlc qtskkpvdie dtinycdvnd fngknavlid 181 ltanperftg yggkqagqiw stiyqdncft igetgeslak dafyrlvsgf hasigthlsk 241 eylntktgkw epnldlfmar ignfpdrvtn myfnyavvak alwkiqpylp efsfcdlvnk 301 eiknkmdnvi sqldtkifne dlvfandlsl tlkdefrsrf knvtkimdcv qcdrcrlwgk 361 iqttgyatal kilfeindad eftkqhivgk ltkyeliall qtfgrlsesi esvnmfekmy 421 gkrlngsenr lssffqnnff nilkeagksi rytieninst kegkkktnns qshvfddlkm 481 pkaeivprps ngtvnkwkka wntevnnvle afrfiyrsyl dlprniwels lmkvykfwnk 541 figvadyvse etrepisykl diq // LOCUS NP_013577 70 aa linear PLN 30-JUN-2025 DEFINITION Cox14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013577 VERSION NP_013577.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182492.1 REFERENCE 1 (residues 1 to 70) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 70) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 70) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 70) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09770. Method: conceptual translation. FEATURES Location/Qualifiers source 1..70 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..70 /product="Cox14p" /calculated_mol_wt="7828" Region 2..56 /region_name="COX14" /note="Cytochrome oxidase c assembly; pfam14880" /db_xref="CDD:434280" CDS 1..70 /gene="COX14" /locus_tag="YML129C" /coded_by="NM_001182492.1:1..213" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:7797555]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15306853]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:15306853]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:7797555|PMID:21068384]" /experiment="EXISTENCE:physical interaction:GO:0070130 negative regulation of mitochondrial translation [PMID:15306853]" /note="Mitochondrial cytochrome c oxidase (complex IV) assembly factor; also involved in translational regulation of Cox1p and prevention of Cox1p aggregation before assembly; associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; located in the mitochondrial membrane" /db_xref="GeneID:854910" /db_xref="SGD:S000004598" ORIGIN 1 mskyawytrv tdtlhrltvl tlvggtlyms gglaytlymn gkkyeqqvtq qkaleednqq 61 lqsptappte // LOCUS NP_013578 513 aa linear PLN 30-JUN-2025 DEFINITION double-strand break repair enhancer MSC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013578 VERSION NP_013578.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182491.1 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09771. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..513 /product="double-strand break repair enhancer MSC1" /calculated_mol_wt="59458" Region 109..145 /region_name="Ish1" /note="Putative nuclear envelope organization protein; pfam10281" /db_xref="CDD:431195" Region 165..201 /region_name="Ish1" /note="Putative nuclear envelope organization protein; pfam10281" /db_xref="CDD:431195" Region 239..276 /region_name="Ish1" /note="Putative nuclear envelope organization protein; pfam10281" /db_xref="CDD:431195" Region 447..482 /region_name="Ish1" /note="Putative nuclear envelope organization protein; pfam10281" /db_xref="CDD:431195" CDS 1..513 /gene="MSC1" /locus_tag="YML128C" /coded_by="NM_001182491.1:1..1542" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:39021806]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:11502169]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:39021806]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511544]" /experiment="EXISTENCE:mutant phenotype:GO:1990166 protein localization to site of double-strand break [PMID:39021806]" /note="Nuclear envelope protein involved in DSB repair during late mitosis; forms nuclear envelope patches associated with Rad52p-containing DNA repair foci, and accelerates homologous recombination downstream of DNA end resection; mutant is defective in directing meiotic recombination events to homologous chromatids; upregulated after DNA damage in late mitosis; null mutant is hypersensitive to DSBs; non-tagged protein is detected in highly purified mitochondria and is phosphorylated" /db_xref="GeneID:854911" /db_xref="SGD:S000004597" ORIGIN 1 mkqfklvnav sasfvliglv lansdsvfdk wtqedladyl rdnkksleky atdsiedlkt 61 easqvwdkha qpkpwwqvws sdsssvsnsn pgwfgytgss dhpvsdwlfd twstdslrnf 121 lkkngvdvdd akaskdslvk takenfnkis kslkssgyyp sssyfdswst kdlqnwlndn 181 gidydkavqs kdelvqkvke niyrtsekae qqrlgllesl dlahqqildt sgqikdtvfd 241 kwssdqltnw leshkvnidk nmakkhdylv rmakensanl kddiywyldy mkresspflt 301 ktpeyvgsvw dssknfltnl yskfrgktdn vindtflvgl dswpkdklkm fldargikys 361 mlstehqlre lvkksrnekl kilpkdyqky fdnsnwsldd ikgwfadkkd dfqdsqtyst 421 imqdfdkvsk ntndakdqia ktwsntfqsw sqedllqylk sfgvpvkqts tkddlinlak 481 qntqwlfgtv kepaykrylh nvknwsksil gfn // LOCUS NP_013579 581 aa linear PLN 30-JUN-2025 DEFINITION Rsc9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013579 VERSION NP_013579.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182490.1 REFERENCE 1 (residues 1 to 581) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 581) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 581) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 581) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09772. Method: conceptual translation. FEATURES Location/Qualifiers source 1..581 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..581 /product="Rsc9p" /calculated_mol_wt="65087" CDS 1..581 /gene="RSC9" /locus_tag="YML127W" /coded_by="NM_001182490.1:1..1746" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:11931764]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:11931764|PMID:10619019|PMID:12183366]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11931764]" /experiment="EXISTENCE:mutant phenotype:GO:0009303 rRNA transcription [PMID:11931764]" /note="Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway" /db_xref="GeneID:854912" /db_xref="SGD:S000004596" ORIGIN 1 mnslasntpl ngtpvseapa tssepvnmfe tmvanpikvs rlqsngvltg paantksihy 61 slanfnvfqs lpketargvd dltrmemall sgipeeikws lkkyltysnk apymislrtl 121 pdllplfktf ilpleriveg lnkssicdsk amdslqmgln allilrnlaq dtdsvqilvk 181 dreiksfilf ilkkfqcvat gdnkwqlyeg natffnelth ytldlmeais syiapamkdd 241 hyfqtlvsil nytkdrymvi silrslsrll vrskaneesa adnldhktls livsflllec 301 dseliiasld flyqyilpgs qritelfksk ecslileatl pnllsyniat pdyhllqkhk 361 irlikrlkpp apkeppnlse dlfqqlfkln eplrstawlr ccfepvqeae ftqislwrsy 421 eskfgqpvre sgrkllpave fiknvsnafn naaaivitdp vtgkkrfvik giqprfkalg 481 iadgeresqv pisalkskfl ndskeitpar qnsipevkfp qelsdvskva ctflcllsnd 541 tddgagsafc qrirplvlhk ladippltla lseymentsg l // LOCUS NP_013580 491 aa linear PLN 30-JUN-2025 DEFINITION hydroxymethylglutaryl-CoA synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013580 VERSION NP_013580.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182489.1 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09773. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..491 /product="hydroxymethylglutaryl-CoA synthase" /EC_number="2.3.3.10" /calculated_mol_wt="54883" Region 45..490 /region_name="HMG-CoA-S_euk" /note="3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade; TIGR01833" /db_xref="CDD:273826" CDS 1..491 /gene="ERG13" /locus_tag="YML126C" /gene_synonym="HMGS" /coded_by="NM_001182489.1:1..1476" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004421 hydroxymethylglutaryl-CoA synthase activity [PMID:12702274|PMID:6148937]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:12702274|PMID:6148937]" /note="3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis" /db_xref="GeneID:854913" /db_xref="SGD:S000004595" ORIGIN 1 mklstklcwc gikgrlrpqk qqqlhntnlq mtelkkqkta eqktrpqnvg ikgiqiyipt 61 qcvnqselek fdgvsqgkyt iglgqtnmsf vndrediysm sltvlsklik synidtnkig 121 rlevgtetli dksksvksvl mqlfgentdv egidtlnacy ggtnalfnsl nwiesnawdg 181 rdaivvcgdi aiydkgaarp tggagtvamw igpdapivfd svrasymeha ydfykpdfts 241 eypyvdghfs ltcyvkaldq vyksyskkai skglvsdpag sdalnvlkyf dynvfhvptc 301 klvtksygrl lyndfranpq lfpevdaela trdydesltd kniektfvnv akpfhkerva 361 qslivptntg nmytasvyaa fasllnyvgs ddlqgkrvgl fsygsglaas lysckivgdv 421 qhiikeldit nklakritet pkdyeaaiel renahlkknf kpqgsiehlq sgvyyltnid 481 dkfrrsydvk k // LOCUS NP_013581 312 aa linear PLN 30-JUN-2025 DEFINITION cytochrome-b5 reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013581 VERSION NP_013581.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182488.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09774. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..312 /product="cytochrome-b5 reductase" /EC_number="1.6.2.2" /calculated_mol_wt="35156" Region 75..312 /region_name="cyt_b5_reduct_like" /note="Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a...; cd06183" /db_xref="CDD:99780" Site order(108,122..125,139..141,143,145..149,187,190..191,312) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99780" Site order(122,124..125) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99780" Site order(141,143,187..188,214..216,244,256,279..283) /site_type="other" /note="NAD binding pocket [chemical binding]" /db_xref="CDD:99780" Site order(146,149,152,158,166,168) /site_type="other" /note="phosphate binding motif [ion binding]" /db_xref="CDD:99780" Site order(182,186..189,191) /site_type="other" /note="beta-alpha-beta structure motif" /db_xref="CDD:99780" CDS 1..312 /gene="PGA3" /locus_tag="YML125C" /gene_synonym="NQR1" /coded_by="NM_001182488.1:1..939" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19239415]" /experiment="EXISTENCE:mutant phenotype:GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H [PMID:19239415]" /experiment="EXISTENCE:mutant phenotype:GO:0015031 protein transport [PMID:16943325]" /note="Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication" /db_xref="GeneID:854914" /db_xref="SGD:S000004594" ORIGIN 1 mskediegtn ildepvhgiy ipaalfvvgv aittymsgel kilwslpilf miifvraysa 61 ykrrrslypd rwtsleledq tiiskntaly rfklktrles ldipaghhva vrvpidgkqe 121 vryynpissk lesgyldlvv kayvdgkvsk yfaglnsgdt vdfkgpigtl nyepnsskhl 181 givaggsgit pvlqilneii tvpedltkvs llyanetend illkdeldem aekyphfqvh 241 yvvhypsdrw tgdvgyitkd qmnrylpeys ednrllicgp dgmnnlalqy akelgwkvns 301 trssgddqvf vf // LOCUS NP_013582 445 aa linear PLN 30-JUN-2025 DEFINITION alpha-tubulin TUB3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013582 VERSION NP_013582.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182487.1 REFERENCE 1 (residues 1 to 445) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 445) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 445) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 445) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09775. Method: conceptual translation. FEATURES Location/Qualifiers source 1..445 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..445 /product="alpha-tubulin TUB3" /calculated_mol_wt="49563" Region 2..436 /region_name="alpha_tubulin" /note="The alpha-tubulin family; cd02186" /db_xref="CDD:276955" Site order(2,200,254..255,257..259,261..262,327,353) /site_type="other" /note="beta/alpha domain interface [polypeptide binding]" /db_xref="CDD:276955" Site order(11..12,15,72,102,144..147,172,207,225,229) /site_type="other" /note="nucleotide binding site [chemical binding]" /db_xref="CDD:276955" Site order(73..74,101..103,106,182,184,225) /site_type="other" /note="alpha/beta domain interface [polypeptide binding]" /db_xref="CDD:276955" CDS 1..445 /gene="TUB3" /locus_tag="YML124C" /coded_by="NM_001182487.1:1..1338" /experiment="EXISTENCE:curator inference:GO:0000070 mitotic sister chromatid segregation [PMID:3540600]" /experiment="EXISTENCE:curator inference:GO:0030473 nuclear migration along microtubule [PMID:3540600]" /experiment="EXISTENCE:curator inference:GO:0045143 homologous chromosome segregation [PMID:3540600]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:24390141]" /experiment="EXISTENCE:genetic interaction:GO:0045298 tubulin complex [PMID:3540600]" /experiment="EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:10793159]" /note="Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p; TUB3 has a paralog, TUB1, that arose from the whole genome duplication" /db_xref="GeneID:854915" /db_xref="SGD:S000004593" ORIGIN 1 mrevisinvg qagcqignac welyslehgi kedghledgl skpkggeegf stffhetgyg 61 kfvpraiyvd lepnvidevr tgrfkelfhp eqlingkeda annyarghyt vgreivdeve 121 erirkmadqc dglqgflfth slgggtgsgl gslllenlsy eygkksklef avypapqlst 181 svvepyntvl tthttlehad ctfmvdneai ydickrnlgi srpsfsnlng liaqvissvt 241 aslrfdgsln vdlnefqtnl vpyprihfpl vsyapilskk rathesnsvs eitnacfepg 301 nqmvkcdptk gkymanclly rgdvvtrdvq raveqvknkk tvqmvdwcpt gfkigicyep 361 psvipssela nvdravcmls nttaiadawk ridqkfdlmy akrafvhwyv gegmeegeft 421 earedlaale rdyievgads yaeef // LOCUS NP_013583 587 aa linear PLN 30-JUN-2025 DEFINITION phosphate transporter PHO84 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013583 VERSION NP_013583.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182486.1 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09776. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..587 /product="phosphate transporter PHO84" /calculated_mol_wt="64251" Region 49..554 /region_name="2A0109" /note="phosphate:H+ symporter; TIGR00887" /db_xref="CDD:129965" CDS 1..587 /gene="PHO84" /locus_tag="YML123C" /coded_by="NM_001182486.1:1..1764" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005315 phosphate transmembrane transporter activity [PMID:7851439]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:2038328]" /experiment="EXISTENCE:direct assay:GO:0006817 phosphate ion transport [PMID:7851439]" /experiment="EXISTENCE:direct assay:GO:0097079 selenite:proton symporter activity [PMID:20688911]" /experiment="EXISTENCE:mutant phenotype:GO:0005315 phosphate transmembrane transporter activity [PMID:2038328]" /experiment="EXISTENCE:mutant phenotype:GO:0005384 manganese ion transmembrane transporter activity [PMID:12923174]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:17804816]" /experiment="EXISTENCE:mutant phenotype:GO:0006817 phosphate ion transport [PMID:2038328]" /experiment="EXISTENCE:mutant phenotype:GO:0006828 manganese ion transport [PMID:12923174]" /experiment="EXISTENCE:mutant phenotype:GO:0097079 selenite:proton symporter activity [PMID:20688911]" /experiment="EXISTENCE:mutant phenotype:GO:0097080 plasma membrane selenite transport [PMID:20688911]" /note="High-affinity inorganic phosphate (Pi) transporter; also low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity" /db_xref="GeneID:854916" /db_xref="SGD:S000004592" ORIGIN 1 mssvnkdtih vaerslhkeh lteggnmafh nhlndfahie dplerrrlal esiddegfgw 61 qqvktisiag vgfltdsydi fainlgitmm syvywhgsmp gpsqtllkvs tsvgtvigqf 121 gfgtladivg rkriygmeli imivctilqt tvahspainf vavltfyriv mgigiggdyp 181 lssiitsefa ttkwrgaimg avfanqawgq isggiialil vaaykgeley ansgaecdar 241 cqkacdqmwr iliglgtvlg laclyfrlti pespryqldv naklelaaaa qeqdgekkih 301 dtsdedmain glerastave sldnhppkas fkdfcrhfgq wkygkillgt agswftldva 361 fyglslnsav ilqtigyags knvykklydt avgnlilica gslpgywvsv ftvdiigrkp 421 iqlagfiilt alfcvigfay hklgdhglla lyvicqffqn fgpntttfiv pgecfptryr 481 stahgisaas gkvgaiiaqt algtlidhnc ardgkptncw lphvmeifal fmllgifttl 541 lipetkrktl eeinelyhde idpatlnfrn knndiesssp sqlqhea // LOCUS NP_001335803 126 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML122C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335803 VERSION NP_001335803.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348863.1 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80323. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..126 /product="uncharacterized protein" /calculated_mol_wt="14342" CDS 1..126 /locus_tag="YML122C" /coded_by="NM_001348863.1:1..381" /note="hypothetical protein; conserved among S. cerevisiae strains; YML122C is not an essential gene" /db_xref="GeneID:854917" /db_xref="SGD:S000004591" ORIGIN 1 mprndsnqyy arwccyrrpi raafarkgpf nsssgyeenv arlkntrssh crtarcqfns 61 stwtcyfqhv grklataidy gspqsieise igavmhqmsc erlslslfsr facllarlkt 121 cvllin // LOCUS NP_013585 310 aa linear PLN 30-JUN-2025 DEFINITION Rag GTPase GTR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013585 VERSION NP_013585.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182484.1 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09777. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..310 /product="Rag GTPase GTR1" /calculated_mol_wt="35717" Region 8..304 /region_name="RagA_like" /note="Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins A and B; cd11384" /db_xref="CDD:206744" Site 13..20 /site_type="other" /note="G1 box" /db_xref="CDD:206744" Site order(18..21,64,126..127,129,165..167) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206744" Site 41 /site_type="other" /note="G2 box" /db_xref="CDD:206744" Site 45..47 /site_type="other" /note="Switch I region" /db_xref="CDD:206744" Site 61..64 /site_type="other" /note="G3 box" /db_xref="CDD:206744" Site order(63..64,85..86) /site_type="other" /note="Switch II region" /db_xref="CDD:206744" Site 126..129 /site_type="other" /note="G4 box" /db_xref="CDD:206744" Site 165..167 /site_type="other" /note="G5 box" /db_xref="CDD:206744" Site order(204,206,242,245..246,249..250,253,256..257,259, 262..269,273,285) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:206744" CDS 1..310 /gene="GTR1" /locus_tag="YML121W" /coded_by="NM_001182484.1:1..933" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:15885099|PMID:19748353]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:22726655|PMID:23716719]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10388807]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10388807]" /experiment="EXISTENCE:direct assay:GO:0031902 late endosome membrane [PMID:16732272]" /experiment="EXISTENCE:direct assay:GO:0071986 Ragulator complex [PMID:16732272]" /experiment="EXISTENCE:direct assay:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:25046117]" /experiment="EXISTENCE:genetic interaction:GO:0010507 negative regulation of autophagy [PMID:25046117]" /experiment="EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:19748353]" /experiment="EXISTENCE:mutant phenotype:GO:0006360 transcription by RNA polymerase I [PMID:15937128]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:15937128]" /experiment="EXISTENCE:mutant phenotype:GO:0006817 phosphate ion transport [PMID:1620108]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0010507 negative regulation of autophagy [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:18258182]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:35158208]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:26387955]" /experiment="EXISTENCE:mutant phenotype:GO:1903778 protein localization to vacuolar membrane [PMID:25046117]" /experiment="EXISTENCE:mutant phenotype:GO:1904263 positive regulation of TORC1 signaling [PMID:26387955|PMID:19748353]" /experiment="EXISTENCE:physical interaction:GO:0006360 transcription by RNA polymerase I [PMID:15937128]" /experiment="EXISTENCE:physical interaction:GO:0006383 transcription by RNA polymerase III [PMID:15937128]" /experiment="EXISTENCE:physical interaction:GO:1990131 Gtr1-Gtr2 GTPase complex [PMID:10388807|PMID:16143306]" /note="Subunit of TORC1-stimulating GTPase and EGO/GSE complex; subunit of Gtr1-Gtr2 GTPase that activates TORC1 in response to amino acid stimulation; subunit of EGO/GSE vacuolar membrane complex that regulates exit from rapamycin-induced growth arrest and sorting of Gap1p; involved in phosphate transport, telomeric chromatin silencing and oxidative stress response; activated by Iml1p (GAP) subunit of SEACIT complex; targeted to vacuole via AP-3 pathway; similar to human RagA and RagB" /db_xref="GeneID:854918" /db_xref="SGD:S000004590" ORIGIN 1 mssnnrkkll lmgrsgsgks smrsiifsny safdtrrlga tidvehshlr flgnmtlnlw 61 dcggqdvfme nyftkqkdhi fqmvqvlihv fdvestevlk dieifakalk qlrkyspdak 121 ifvllhkmdl vqldkreelf qimmknlset ssefgfpnli gfptsiwdes lykawsqivc 181 slipnmsnhq snlkkfkeim naleiilfer ttflvicssn gensnenhds sdnnnvlldp 241 krfekisnim knfkqsctkl ksgfktliln nniyvselss nmvcfivlkd mnipqelvle 301 nikkakeffq // LOCUS NP_013586 513 aa linear PLN 30-JUN-2025 DEFINITION NADH-ubiquinone reductase (H(+)-translocating) NDI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013586 VERSION NP_013586.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182483.1 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09778. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..513 /product="NADH-ubiquinone reductase (H(+)-translocating) NDI1" /EC_number="1.6.5.9" /calculated_mol_wt="57119" Region 53..508 /region_name="PTZ00318" /note="NADH dehydrogenase-like protein; Provisional" /db_xref="CDD:185553" CDS 1..513 /gene="NDI1" /locus_tag="YML120C" /coded_by="NM_001182483.1:1..1542" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:11502169]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:1900238]" /experiment="EXISTENCE:direct assay:GO:0006120 mitochondrial electron transport, NADH to ubiquinone [PMID:1900238]" /experiment="EXISTENCE:direct assay:GO:0008137 NADH dehydrogenase (ubiquinone) activity [PMID:3138118]" /experiment="EXISTENCE:mutant phenotype:GO:0005759 mitochondrial matrix [PMID:1900238]" /experiment="EXISTENCE:mutant phenotype:GO:0043065 positive regulation of apoptotic process [PMID:16436509]" /note="NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy" /db_xref="GeneID:854919" /db_xref="SGD:S000004589" ORIGIN 1 mlsknlysnk rlltstntlv rfastrstgv ensgagptsf ktmkvidpqh sdkpnvlilg 61 sgwgaisflk hidtkkynvs iisprsyflf tpllpsapvg tvdeksiiep ivnfalkkkg 121 nvtyyeaeat sinpdrntvt ikslsavsql yqpenhlglh qaepaeikyd ylisavgaep 181 ntfgipgvtd yghflkeipn sleirrtfaa nlekanllpk gdperrrlls ivvvgggptg 241 veaagelqdy vhqdlrkflp alaeevqihl vealpivlnm fekklssyaq shlentsikv 301 hlrtavakve ekqllaktkh edgkiteeti pygtliwatg nkarpvitdl fkkipeqnss 361 krglavndfl qvkgsnnifa igdnafaglp ptaqvahqea eylaknfdkm aqipnfqknl 421 ssrkdkidll feennfkpfk yndlgalayl gseraiatir sgkrtfytgg glmtfylwri 481 lylsmilsar srlkvffdwi klaffkrdff kgl // LOCUS NP_013587 357 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML119W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013587 VERSION NP_013587.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182482.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09779. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..357 /product="uncharacterized protein" /calculated_mol_wt="39929" CDS 1..357 /locus_tag="YML119W" /coded_by="NM_001182482.1:1..1074" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141]" /note="hypothetical protein; YML119W is not an essential gene; potential Cdc28p substrate" /db_xref="GeneID:854920" /db_xref="SGD:S000004588" ORIGIN 1 mspspsvspr rtlnnkssyi nnsgglvlpp tqfnlnqqpv lsfqqkatfd snqqffyype 61 sptknlrprf nsisqvnkgv nedhytgggs snnnrpsryt ntmgaantnv nshphhqsvs 121 hlnskslkfn qtkevssine iifpsrtctk kryftkpidl ygtrsstsva pkltnsptks 181 ktnfnikkci lprsvvttyk lpspvhetid diskkiiill islkfeknyh flqpiqlstn 241 sktrisksld elcgvqltst lrqqkqlqgn skpvknlpns nakqragasv stnanesfel 301 sfdgkamdrs difrmvdsfs iaisdedeed eeedsfqqrs annrilpaei lsneplk // LOCUS NP_013588 505 aa linear PLN 30-JUN-2025 DEFINITION 3'-5' poly(A) RNA exonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_013588 VERSION NP_013588.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182481.1 REFERENCE 1 (residues 1 to 505) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 505) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 505) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 505) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09780. Method: conceptual translation. FEATURES Location/Qualifiers source 1..505 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..505 /product="3'-5' poly(A) RNA exonuclease" /calculated_mol_wt="57611" Region 67..496 /region_name="CCR4" /note="mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]; COG5239" /db_xref="CDD:227564" CDS 1..505 /gene="NGL3" /locus_tag="YML118W" /coded_by="NM_001182481.1:1..1518" /experiment="EXISTENCE:direct assay:GO:0004535 poly(A)-specific ribonuclease activity [PMID:21965533]" /experiment="EXISTENCE:direct assay:GO:0043633 polyadenylation-dependent RNA catabolic process [PMID:21965533]" /note="3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication" /db_xref="GeneID:854921" /db_xref="SGD:S000004587" ORIGIN 1 mdsqvegkis psqkesssts glvspsedgp ahqkihrdql svdqikkire eraqkrqvrr 61 nslisqgkdp dfptpdlqfi erpflpinhd nskgltpati qvtqdsldvk imtyntlaqt 121 lirrdffpes gpalkwhkrs kvlvhelkky rpdvvslqev dynelnfwqe nfhklgfdvi 181 fkrhegkthg llvawnnkkf qldndwmldy dnilagnvis artrtknial iislyfkgit 241 dsssrgiiva nthlfwhpfg vferlrqsyl vlqkiqeika cskyngwhsl lmgdfntepe 301 eppylaitkr plilkgpira mvecslayry skkrngeesd qddeecdeks rgeghsdqpq 361 npkpesftat keekalvnql valhnslhvk gvslygigyg kvhpenangs hgepglsnwa 421 ntwcglldyi fyiegdhnqd trqkeplnaf egnnnvkiig ylrmpcaqem pkhsqpfege 481 yasdhislmc qirlffggek vhslk // LOCUS NP_013589 1134 aa linear PLN 30-JUN-2025 DEFINITION Nab6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013589 VERSION NP_013589.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182479.1 REFERENCE 1 (residues 1 to 1134) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1134) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1134) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1134) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09781. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1134 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1134 /product="Nab6p" /calculated_mol_wt="126008" Region 60..99 /region_name="RRM" /note="Putative RRM domain; pfam10378" /db_xref="CDD:402136" Region 200..560 /region_name="Nab6_mRNP_bdg" /note="RNA-recognition motif; pfam10567" /db_xref="CDD:431363" Region 652..725 /region_name="RRM3_MRN1" /note="RNA recognition motif 3 (RRM3) found in RNA-binding protein MRN1 and similar proteins; cd12521" /db_xref="CDD:240965" Region 741..860 /region_name="RRM_SF" /note="RNA recognition motif (RRM) superfamily; cl17169" /db_xref="CDD:473069" CDS 1..1134 /gene="NAB6" /locus_tag="YML117W" /coded_by="NM_001182479.1:1..3405" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003730 mRNA 3'-UTR binding [PMID:36862555]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:23222640]" /experiment="EXISTENCE:genetic interaction:GO:0070935 3'-UTR-mediated mRNA stabilization [PMID:36862555]" /experiment="EXISTENCE:genetic interaction:GO:1990394 cellular response to cell wall damage [PMID:36862555]" /experiment="EXISTENCE:mutant phenotype:GO:0070935 3'-UTR-mediated mRNA stabilization [PMID:36862555]" /experiment="EXISTENCE:mutant phenotype:GO:1990394 cellular response to cell wall damage [PMID:36862555]" /note="mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and stabilizes these mRNAs, acting in parallel to cell wall integrity signaling to maintain expression of cell wall genes during stress; acts antagonistically to Nab6p; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP" /db_xref="GeneID:854922" /db_xref="SGD:S000004585" ORIGIN 1 msnsnskkpv anyayrqqqd yngmnamvgn pmmyhpvdfv ngagqygpsq hpayytnspl 61 pnipptpfdt aygaslfpsh llmgspfvss pnmqsgynsa rssnlkrkay srpvsnhngy 121 ngnsnsnqnn tnngmvtpsn yyrmgrnsfs rnnnstrnvt hnnnkgcdtr nnsgrrtfar 181 nnifddilpe mllqrpfcin ykvlptgdda yrtrsllien vdhsidlhsi vknfvksntl 241 esaylieggk sddskdvetk nlsilisflt kgdclnfynn ilqrlsefkt flksealnlk 301 fvclnydpkc lptfieseal tenaeeadit ngstmisasl hhniankdat rsiiiefksp 361 veksdlfkkk lqfldrsknk ryilesidlv ntdvpsnqfp enyavltfln ismaievldy 421 lkkysknlgi skcfyvslap lvvssarssv aniyegktst hrlsvpsvta gnnndsnnng 481 nnnksnmsgi ttlnnnssig vsvyghsnms ltslsssvsl neeidmlatk lqgveldgty 541 leinyrdyqt ptieehsthl snvkisktte nsrqfsqdip splplnehmf mndsnqsnga 601 iipqqliatp spvspnlqmn qrvlpnpitq sleqnfnvsa kvassmgsdi gnrtiyigni 661 nprskaedic nvvrggilqs ikyipekkic fvtfieapsa vqfyansfid pivlhgnmlr 721 vgwghysgpl pklislavti gasrnvyvsl pefafkekfi hdpqykklhe tlslpdaeql 781 redfstygdi eqinylsdsh ccwinfmnis saislveemn kestvqnesg evtlkratee 841 kfggrykgll inygkdrcgn inknliagkn srfykkvkrp synirlskle ekrrqneide 901 kekafdkpln leslgislda hkdngggetg tanntghene seleaeneng netgsfgglg 961 lavassdvkr atsdetdyed ifnkssgssd sssdvevimh spsdpeyalk sqtlrsssqt 1021 vinskrpvki edeeeavgms qlnyrsslrq apprapstls ynhsknnetp mqdiftnget 1081 annrkkkrgs farhrtipgs dvmaqylaqv qhstfmyaan ilgasaednt hpde // LOCUS NP_013591 542 aa linear PLN 30-JUN-2025 DEFINITION borate transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_013591 VERSION NP_013591.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182478.1 REFERENCE 1 (residues 1 to 542) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 542) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 542) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 542) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09782. Method: conceptual translation. FEATURES Location/Qualifiers source 1..542 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..542 /product="borate transporter" /calculated_mol_wt="59852" Region 73..517 /region_name="MFS_Amf1_MDR_like" /note="Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; cd17476" /db_xref="CDD:341029" Site order(82..83,86..87,90,122,175..176,178..180,183,205, 208..209,212,338,341..342,345..347,350,381,385,438..439, 443,447,463,466..467,470..471,474) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:341029" CDS 1..542 /gene="ATR1" /locus_tag="YML116W" /gene_synonym="SNQ1" /coded_by="NM_001182478.1:1..1629" /experiment="EXISTENCE:direct assay:GO:0005773 vacuole [PMID:19414602]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19414602]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:2123132]" /experiment="EXISTENCE:mutant phenotype:GO:0046713 borate transport [PMID:19414602]" /experiment="EXISTENCE:mutant phenotype:GO:0080139 borate efflux transmembrane transporter activity [PMID:19414602]" /note="Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854924" /db_xref="SGD:S000004584" ORIGIN 1 mgnqslvvlt eskgeyenet elpvkkssrd nnigesltat aftqsedemv dsnqkwqnpn 61 yfkyawqeyl fiftcmisql lnqagttqtl simnilsdsf gsegnskswl masfplvsgs 121 filisgrlgd iyglkkmllv gyvlviiwsl icgitkysgs dtffiisraf qglgiafvlp 181 nvlgiigniy vggtfrkniv isfvgamapi gatlgclfag ligtedpkqw pwafyaysia 241 afinfvlsiy aipstiptni hhfsmdwigs vlgviglill nfvwnqapis gwnqayiivi 301 liisviflvv fiiyeirfak tpllpravik drhmiqimla lffgwgsfgi ftfyyfqfql 361 nirqytalwa ggtyfmfliw giiaallvgf tiknvspsvf lffsmvafnv gsimasvtpv 421 hetyfrtqlg tmiilsfgmd lsfpassiif sdnlpmeyqg magslvntvv nysmslclgm 481 gatvetqvns dgkhllkgyr gaqylgigla slacmisgly mvesfikgrr araaaeydct 541 va // LOCUS NP_013592 535 aa linear PLN 30-JUN-2025 DEFINITION Van1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013592 VERSION NP_013592.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182477.1 REFERENCE 1 (residues 1 to 535) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 535) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 535) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 535) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 535) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09783. Method: conceptual translation. FEATURES Location/Qualifiers source 1..535 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..535 /product="Van1p" /calculated_mol_wt="60961" Region 171..480 /region_name="Anp1" /note="pfam03452" /db_xref="CDD:427303" CDS 1..535 /gene="VAN1" /locus_tag="YML115C" /gene_synonym="LDB13; VRG7; VRG8" /coded_by="NM_001182477.1:1..1608" /experiment="EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:12235155]" /experiment="EXISTENCE:direct assay:GO:0000136 mannan polymerase complex [PMID:9430634]" /experiment="EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:9430634]" /experiment="EXISTENCE:mutant phenotype:GO:0000032 cell wall mannoprotein biosynthetic process [PMID:12235155]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9430634]" /note="Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant" /db_xref="GeneID:854925" /db_xref="SGD:S000004583" ORIGIN 1 mgmffnlrsn ikkkamdngl slpisrngss nnikdkrseh nsnslkgkyr yqprstpskf 61 qltvsitsli iiavlslylf isflsgmgig vstqngrsll gsskssenyk tidledeeyy 121 dydfedidpe viskfddgvq hylisqfgse vltpkddeky qrelnmlfds tveeydlsnf 181 egapngletr dhillciplr naadvlplmf khlmnltyph elidlaflvs dcsegdttld 241 aliaysrhlq ngtlsqifqe idavidsqtk gtdklylkym degyinrvhq afsppfheny 301 dkpfrsvqif qkdfgqvigq gfsdrhavkv qgirrklmgr arnwltanal kpyhswvywr 361 dadvelcpgs viqdlmskny dvivpnvwrp lptflgteqp ydlnswmesq ealalaktld 421 eddvivegya eyptwrvhla yirdaegdpn eavdldgvgg vsilakakif rngvqfpaft 481 fenhaeteaf gkmakkmgyr vgglphytiw hiyepsdddl keiasrerek rrqse // LOCUS NP_013593 510 aa linear PLN 30-JUN-2025 DEFINITION Taf8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013593 VERSION NP_013593.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182476.1 REFERENCE 1 (residues 1 to 510) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 510) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 510) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 510) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09784. Method: conceptual translation. FEATURES Location/Qualifiers source 1..510 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..510 /product="Taf8p" /calculated_mol_wt="57855" Region 175..222 /region_name="TAF8_C" /note="Transcription factor TFIID complex subunit 8 C-term; pfam10406" /db_xref="CDD:431262" CDS 1..510 /gene="TAF8" /locus_tag="YML114C" /gene_synonym="TAF65" /coded_by="NM_001182476.1:1..1533" /experiment="EXISTENCE:curator inference:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /note="TFIID subunit (65 kDa); involved in RNA polymerase II transcription initiation" /db_xref="GeneID:854926" /db_xref="SGD:S000004582" ORIGIN 1 mtsktsesgt gtqstivqlr nlpdlteish leidapvvei lkktvlfqln slnicisnfa 61 ldelvnlvtv qmdgmfrnlh nltllqrrsq asqadlklll refnldapsl yqqfqasefi 121 kskhsteyek lmswsslaal phneedeede lnnieeqqne invllppsnp lekqipswlp 181 nfppdhtykf tpefnhpitd lktikkeivk esqesekall nlnkslshis sasntpqppg 241 lddedaieqq leiwgnalee rkptiteksf nennieqyak yrvelarerv tkfevnqlkr 301 tknpflkise tlylpesphq shktiqktie lqfrksmtlf mhnlpkvqkl kkekirmake 361 erakslkrrq eelisqrtkr eqdeghdlel llnneharda addtttpnal nnstivintn 421 aededddinl fgilgssede nemssmpaen lvaesepptm taqdttnttp vahnttnida 481 ttshsphstp nenaptsppa diatdhditm // LOCUS NP_013594 248 aa linear PLN 30-JUN-2025 DEFINITION Dat1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013594 VERSION NP_013594.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182475.1 REFERENCE 1 (residues 1 to 248) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 248) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 248) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 248) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09785. Method: conceptual translation. FEATURES Location/Qualifiers source 1..248 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..248 /product="Dat1p" /calculated_mol_wt="26936" CDS 1..248 /gene="DAT1" /locus_tag="YML113W" /coded_by="NM_001182475.1:1..747" /experiment="EXISTENCE:direct assay:GO:0003680 minor groove of adenine-thymine-rich DNA binding [PMID:2670564]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:8248247]" /note="DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; relocalizes to the cytosol in response to hypoxia; not essential for viability" /db_xref="GeneID:854927" /db_xref="SGD:S000004581" ORIGIN 1 maktlaqgrk pgsgrkpgkg ktlregrkpg sgrrrrqdtg gketdgsqqd qesrlissrd 61 meavdalrel thspsshsah nssaapppha aaastslpps ldythqsfmd qqqqqqqqqq 121 qqllqqqrvd vvppkpfith killsstgns gghvnsnyna dhsinhnsnh nlnsnvnvnm 181 nftingsnqd psssflmgpy nylqrpfivk pyldlststa asnqprtqps paahitknsd 241 steknati // LOCUS NP_013595 296 aa linear PLN 30-JUN-2025 DEFINITION Ctk3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013595 VERSION NP_013595.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182474.1 REFERENCE 1 (residues 1 to 296) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 296) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 296) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 296) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 296) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09786. Method: conceptual translation. FEATURES Location/Qualifiers source 1..296 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..296 /product="Ctk3p" /calculated_mol_wt="34678" Region 225..284 /region_name="CTK3_C" /note="CTD kinase subunit gamma CTK3 C-terminus; pfam12350" /db_xref="CDD:432498" CDS 1..296 /gene="CTK3" /locus_tag="YML112W" /coded_by="NM_001182474.1:1..891" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15520468]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15520468]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:11118453]" /experiment="EXISTENCE:direct assay:GO:0032786 positive regulation of DNA-templated transcription, elongation [PMID:9110987]" /experiment="EXISTENCE:direct assay:GO:0070692 CTDK-1 complex [PMID:7565723]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15520468]" /experiment="EXISTENCE:physical interaction:GO:0045903 positive regulation of translational fidelity [PMID:17545469]" /note="Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854928" /db_xref="SGD:S000004580" ORIGIN 1 mdslearlqf iqvlknlqkt lhktrdsits sstttppssq qklnndpiqf ylrnyrhhye 61 dfhqclfdtt mkmdpldrld vviyyvriir nlyphshsnt nvtkvlnevl lmdidlvfel 121 clpcqdwksl tnqatckelf ldlsklihyd atsvthtpsd ttlidattwy svkterttkd 181 ykeslqrtes llkdrdlkkl affqqfnsdt tainpdlqtq ptnanillhr meadrelhkr 241 sketswyier psndildese fkslwthfet tdsgfdkddy knikalndia kasyiy // LOCUS NP_013596 920 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-ubiquitin ligase BUL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013596 VERSION NP_013596.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182473.1 REFERENCE 1 (residues 1 to 920) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 920) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 920) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 920) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 920) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 920) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 920) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09787. Method: conceptual translation. FEATURES Location/Qualifiers source 1..920 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..920 /product="ubiquitin-ubiquitin ligase BUL2" /calculated_mol_wt="104656" Region 87..525 /region_name="Bul1_N" /note="Bul1 N terminus; pfam04425" /db_xref="CDD:398229" Region 646..918 /region_name="Bul1_C" /note="Bul1 C terminus; pfam04426" /db_xref="CDD:367936" CDS 1..920 /gene="BUL2" /locus_tag="YML111W" /coded_by="NM_001182473.1:1..2763" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0034450 ubiquitin-ubiquitin ligase activity [PMID:11352928]" /experiment="EXISTENCE:mutant phenotype:GO:0000151 ubiquitin ligase complex [PMID:11352928]" /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:9931424]" /experiment="EXISTENCE:mutant phenotype:GO:0006513 protein monoubiquitination [PMID:9931424]" /note="Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex; ubiquitin-binding adaptor involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication" /db_xref="GeneID:854929" /db_xref="SGD:S000004579" ORIGIN 1 mtftfstssr kngrpplksv stednihllr krrqqqlssn stdnslhpns gqtprasdsq 61 dddirsastt nldrlrqere enslemdctq srlshranml vdvlpsfemy nalhrhipqg 121 nvdpdrhdfp psyqevrtqr mtilpsndns versqltavp gsenacnnat ahsltnlhpl 181 qtqhltinst rsggqslhss sdtnisqipf eddlndsdni fidklytlpk lstpieidir 241 itktasiphe rpeeqsilke ytsgdiihgy clienrssqp lkfemfyvtl eayisvidrq 301 kgkrtlkrfl rmvdlsasws ytnitpstgi nivpgerdfd daiiglsnsr elkpntkykk 361 ffmfklptql ldvtckqeqf shcllppsfg idkyknncky sgikvnsvlg cghlgtkgsp 421 iltldmaddn lsinytidak ivgkdkrtsk lnimkekeyn lrvmpfpfag vtnqqnektc 481 lrqlknlesl iedrfealnk ifkklelnea isnvdihdtd isgtldgned ldsdeilrrk 541 ldqlhinnri ddtasqspsy dsknmapken lvetelrykf knknksnssl fshflssset 601 gssstgphvy nsglivlsvk kpqstlpyws psllrktnkf eakseqeken wqrlmgmlpe 661 gvktpltkld vhltciqsnn saghkppeis svttefvvit aksdnsipik fctellmnen 721 rlnklktkfl tyqkkvheyr kkfeenhakl nelynrnrdh ftpkellftn fisdqinndi 781 dslaglkvni idlhdifkkq ihtfeeened iiskkgssnp psasssnnnf lqatfsngas 841 tatkftqqiv hewekvkplq ykrdvtvnlk lnpniketlv pnletclccr fycvrvnikf 901 dnhlgsmkvd ipvdvkklqi // LOCUS NP_013597 307 aa linear PLN 30-JUN-2025 DEFINITION 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013597 VERSION NP_013597.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182472.1 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09788. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..307 /product="2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase" /EC_number="2.1.1.201" /calculated_mol_wt="34554" Region 67..306 /region_name="Ubie_methyltran" /note="ubiE/COQ5 methyltransferase family; pfam01209" /db_xref="CDD:395966" Site order(118..124,148..149,178..180,196) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..307 /gene="COQ5" /locus_tag="YML110C" /gene_synonym="DBI56" /coded_by="NM_001182472.1:1..924" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:9083048]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:9083048]" /experiment="EXISTENCE:mutant phenotype:GO:0008425 2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity [PMID:9083049]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:9083049]" /note="2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; respiratory defect of the null mutant is partially complemented by human COQ5" /db_xref="GeneID:854930" /db_xref="SGD:S000004578" ORIGIN 1 mlissrivrs slvnvplrls rcftqahrac keeevnspls saaeqpeqky thfgsktvlk 61 stkqklvgdv fssvanrydl mndvmslgih rlwkdhfink ldagkrpnst tplnfidvag 121 gsgdiafgll dhaeskfgdt estmdivdin pdmlkegekr ameqgkyfkd prvrflvsng 181 ekleeidsds kdiytvsfgi rnftdiqkgl ntayrvlkpg gifyclefsk ienplmdfay 241 qqwakvlpvm gsmiandyds yqylvesier fpdqetfksm iekagfksag yesltfgica 301 ihwgikv // LOCUS NP_013598 942 aa linear PLN 30-JUN-2025 DEFINITION Zds2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013598 VERSION NP_013598.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182471.1 REFERENCE 1 (residues 1 to 942) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 942) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 942) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 942) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 942) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 942) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 942) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09789. Method: conceptual translation. FEATURES Location/Qualifiers source 1..942 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..942 /product="Zds2p" /calculated_mol_wt="105365" Region 856..904 /region_name="Zds_C" /note="Activator of mitotic machinery Cdc14 phosphatase activation C-term; pfam08632" /db_xref="CDD:370018" CDS 1..942 /gene="ZDS2" /locus_tag="YML109W" /gene_synonym="CES4" /coded_by="NM_001182471.1:1..2829" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21536748]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:20980617]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:21536748]" /experiment="EXISTENCE:genetic interaction:GO:0010971 positive regulation of G2/M transition of mitotic cell cycle [PMID:20980617]" /experiment="EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:8816439]" /experiment="EXISTENCE:genetic interaction:GO:0032880 regulation of protein localization [PMID:18762578]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:10662670]" /experiment="EXISTENCE:mutant phenotype:GO:0010971 positive regulation of G2/M transition of mitotic cell cycle [PMID:21536748]" /note="Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication" /db_xref="GeneID:854931" /db_xref="SGD:S000004577" ORIGIN 1 mvlmedmqnk dghntvenss ggtdsnnniq mrrmrktqls kkelfekrks dvliaaksld 61 teiqnvknlk rlsigsmdlv idpelefkvn srnsyssdss keslqeslhe eniirseqke 121 eqgsednday eegdatnvdd siditqteyl hdeetlekek iirnasssts ssarvtsrnr 181 rlsgvktlah dvvldvendh dskmvdltqn llwvpadqhp nvkpenylel iqdtlqniqi 241 stnqdidenk lelgnnhvis nrkrtgsvvr rpsrlktsyt kfddepplad kpqegeiqvd 301 krisssdikt irsvslkeit eeltkisnna gltdsdavtl arslsmsgsf tneslhlngn 361 htendnefas nmfnetglti persslrrsk fntykirleg sslpqavkln slmniqtndn 421 rrsasspasy tqvpqeqasl ndfheifdhy rrtstdwste nekyvdstny ysdeedltha 481 sisqesslls tdssnnsvli kphntgsmis ekldqhvsss eksntnnsea nhgwswlnss 541 ngslnaneqt yqqltddedd eecvdnekad fvnlsvsrra kstkraseri nhsknrhspi 601 fqihseeaks vvitpsvvss sesqpskpta pavvekkvel ptdtqasthk knslekrlak 661 lfkrkqhngt cksdvkvikk svkkelkkka shsslskfrk spkkkpqeae verpssptkt 721 ittedidtas viepevrssn astllpdsht shssefvvet iseldgddsf disggdvnyd 781 vevhssisrd ttagleedig aeredntspt apqistlppr kltfedvvkp dysnapikft 841 dsafgfplpm itnstvimfd hrlginvera iyrlshlkls dpgrelrqqv llsnfmysyl 901 nlvnhtlyme qvgtgdiafn gdsalgmmdk ndsdgtilip di // LOCUS NP_013599 105 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML108W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013599 VERSION NP_013599.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182470.1 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09790. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..105 /product="uncharacterized protein" /calculated_mol_wt="12208" Region 1..104 /region_name="DUF1892" /note="Protein of unknown function (DUF1892); pfam08987" /db_xref="CDD:370227" CDS 1..105 /locus_tag="YML108W" /coded_by="NM_001182470.1:1..318" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /note="hypothetical protein; structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:854863" /db_xref="SGD:S000004576" ORIGIN 1 msksntyrml vlleddtkin kedekflkgk pgkmhefvde lilpfnvdel delntwfdkf 61 daeicipneg hikyeissdg livlmldkei eevvekvkkf veenn // LOCUS NP_013600 334 aa linear PLN 30-JUN-2025 DEFINITION Pml39p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013600 VERSION NP_013600.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182469.1 REFERENCE 1 (residues 1 to 334) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 334) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 334) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 334) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09791. On Oct 2, 2003 this sequence version replaced NP_013600.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..334 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..334 /product="Pml39p" /calculated_mol_wt="39076" CDS 1..334 /gene="PML39" /locus_tag="YML107C" /coded_by="NM_001182469.1:1..1005" /experiment="EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:16162818]" /experiment="EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:36857168]" /experiment="EXISTENCE:mutant phenotype:GO:0051237 maintenance of RNA location [PMID:16162818]" /note="Protein required for nuclear retention of unspliced pre-mRNAs; required along with Mlp1p and Pml1p; anchored to the nuclear pore complex through an interaction between its bimodular nuclear basket-interaction domain (NuBaID) and Mlp1p and Mlp2p; localizes to the nuclear basket enables linkage between subpopulations of Mlp1p; associates with the subset of nuclear pores farthest from the nucleolus; homologous to human ZC3HC1, a NuBaID containing protein" /db_xref="GeneID:854864" /db_xref="SGD:S000004575" ORIGIN 1 mekdalevrl ksirhsldkn tkllpgkyrn tlgerlitkw rykkkshngs smlpekcksh 61 vqlyddlvqe sskhfvgfrl hdlrallkri csiqnytrhv liewdvrwvn pltlaskgwe 121 pyqsasqsqv pfkcccchai mtipllkngd dvadytmkln ekiwnsniig nhlqkcpwre 181 nqvdlnkeyy lssqnlirei erihteidri vsgsnefslk rnssrifhyl sekeiqklaf 241 ffdckdyslv gllllgytkf qkddlvqcta cfhraslkkl eytefnghal wcryynkell 301 ptmlleligk edklitklgv gerlnkleav lqtl // LOCUS NP_013601 226 aa linear PLN 30-JUN-2025 DEFINITION orotate phosphoribosyltransferase URA5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013601 VERSION NP_013601.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182468.1 REFERENCE 1 (residues 1 to 226) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 226) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 226) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09792. Method: conceptual translation. FEATURES Location/Qualifiers source 1..226 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..226 /product="orotate phosphoribosyltransferase URA5" /EC_number="2.4.2.10" /calculated_mol_wt="24533" Region 14..199 /region_name="pyrE" /note="orotate phosphoribosyltransferase; TIGR00336" /db_xref="CDD:129436" Site order(75,77,132..134,136..140,164) /site_type="active" /db_xref="CDD:206754" CDS 1..226 /gene="URA5" /locus_tag="YML106W" /gene_synonym="PYR5" /coded_by="NM_001182468.1:1..681" /experiment="EXISTENCE:direct assay:GO:0004588 orotate phosphoribosyltransferase activity [PMID:9882434]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0046132 pyrimidine ribonucleoside biosynthetic process [PMID:9882434]" /experiment="EXISTENCE:mutant phenotype:GO:0004588 orotate phosphoribosyltransferase activity [PMID:4550660]" /experiment="EXISTENCE:mutant phenotype:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:4550660]" /experiment="EXISTENCE:mutant phenotype:GO:0046132 pyrimidine ribonucleoside biosynthetic process [PMID:4550660]" /note="Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication" /db_xref="GeneID:854865" /db_xref="SGD:S000004574" ORIGIN 1 mpimledyqk nflelaiecq alrfgsfklk sgrespyffn lglfntgkll snlatayaia 61 iiqsdlkfdv ifgpaykgip laaivcvkla eiggskfqni qyafnrkeak dhgeggiivg 121 salenkrili iddvmtagta ineafeiisn akgqvvgsii aldrqevvst ddkeglsatq 181 tvskkygipv lsivslihii tylegritae ekskieqylq tygasa // LOCUS NP_013602 273 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding signal recognition particle subunit SEC65 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013602 VERSION NP_013602.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182467.1 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09793. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..273 /product="RNA-binding signal recognition particle subunit SEC65" /calculated_mol_wt="31039" Region 100..196 /region_name="SRP19" /note="SRP19 protein; pfam01922" /db_xref="CDD:460383" CDS 1..273 /gene="SEC65" /locus_tag="YML105C" /coded_by="NM_001182467.1:1..822" /experiment="EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282|PMID:1313947]" /experiment="EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]" /experiment="EXISTENCE:direct assay:GO:0008312 7S RNA binding [PMID:14681587]" /experiment="EXISTENCE:mutant phenotype:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:1313948]" /experiment="EXISTENCE:mutant phenotype:GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition [PMID:1313947]" /note="Subunit of the signal recognition particle (SRP); involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19" /db_xref="GeneID:854866" /db_xref="SGD:S000004573" ORIGIN 1 mprleeiddf ndiddldmel aeldpslrtp iapkitpkvv rsqdqenpaf lpgtnnnsns 61 nnnssnekeq lsfinpktgk verseaiskk dleevkrfqv lypcyfdinr shkegrrvpk 121 elavenplak tmadavrelg ilcifegekc hpqdfgnpgr irvlfkengq ligaatkfkg 181 gkrqlmkavg eymkrhptti eslreipygp dfdniefkki prvkgfkmne ivplhspflm 241 ghpmtksvye tpkitaaeks fkppknkykv vrr // LOCUS NP_013603 1127 aa linear PLN 30-JUN-2025 DEFINITION Mdm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013603 VERSION NP_013603.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182466.1 REFERENCE 1 (residues 1 to 1127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1127) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09794. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1127 /product="Mdm1p" /calculated_mol_wt="129850" Region 85..276 /region_name="PXA" /note="Domain associated with PX domains; smart00313" /db_xref="CDD:214611" Region 462..567 /region_name="RGS" /note="Regulator of G protein signaling (RGS) domain superfamily; cl02565" /db_xref="CDD:470619" Region 763..900 /region_name="PX_MDM1p" /note="The phosphoinositide binding Phox Homology domain of yeast MDM1p; cd06876" /db_xref="CDD:132786" Site order(824..826,853..854,871) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:132786" Region 993..1106 /region_name="Nexin_C" /note="Sorting nexin C terminal; pfam08628" /db_xref="CDD:462541" CDS 1..1127 /gene="MDM1" /locus_tag="YML104C" /coded_by="NM_001182466.1:1..3384" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:26283797]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:2202739|PMID:9245780]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:33740659]" /experiment="EXISTENCE:mutant phenotype:GO:1990854 vacuole-ER tethering [PMID:26283797]" /note="PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs; anchored in the ER membrane at nucleus-vacuole junctions and binds phosphatidylinositol 3-phosphate (PtdIns-3-P) in the vacuolar membrane via its Phox homology (PX) domain; expressed predominantly in late G1 to early S phase of the cell cycle; mutation affects nuclear and mitochondrial transmission to daughter buds; similar to 4 human genes, one of which (SNX14) is associated with neurological disease" /db_xref="GeneID:854867" /db_xref="SGD:S000004572" ORIGIN 1 mpkfpqfrli lvlfylismi qwsvitfslg fflnvcifay fvffkslpdl pkpqprfvdi 61 vpessntvdv dkelksvegl iqdgnaqigk elesivnlii kdfvqpwftk idknsdaefl 121 kvikwrllqt llvvkdklmk ndsaslivlk llpifnkhfs tfcdareavl sdltlerhks 181 anidlqiave fnknykihks lslkpnalqk eieksirktv igllphlfdn deldsllvft 241 lmtevlttci isplifkftd pdswnlrivs lsqnyfeekh kvhkirrmls kelqdhrkvm 301 ndvankdvge psseklelna eytgkqfehy lnqldslldl sdikyvaysl alkiyqlken 361 ehltkenlky kkrlllslnl iesklsfpgs eidtaskkla reanypdlnm dngivlkema 421 sfltsitlkd ivddseflpf fesflgsvpe tqgstfleys qtiesfknpl edatsediis 481 gysgistmql qeisskffhn nnlqnmklld eglvkniilf rnsfqinnde dtfilarksv 541 lllqteaiky lddrflplfk ktpsflkmls tshiistdiy ahflsriggv nnpeqnkiik 601 dnvktdfmnp vrifanpgit daldnivngs gskphksris snprysqlfg sendnifkdk 661 lfddendnts eisvvedqld hprnmekvsv ssgnsglnps qfygsnnfrd niasltisid 721 qiekelellr hlilkadltn nqmqlkilkk sqrtllkele mkellkqqym vqengnslfr 781 ktkiyirsyf senssnglke ityyiinihh fnngqvsswd marryneffe lntylkknfr 841 dlmrqlqdlf pskvkmslky hvtktllyee rkqklekylr ellsiseice dnifrrfltd 901 ptpfklnkey mhddileepl hepigssnst snsssvvdlq ssedggelnf yederhfftd 961 sgypfysqnk sfvkqicdlf islfalnkan agwlrgraii tvlqqllgst iekyikvsiq 1021 klrsedqvfe aivtfknmlw gdnglferkr netaeatrse gerlrteqla ltslqrlfad 1081 tcgrvvglrd sheaagrvha mlqnpylnas lllealdail ldiicnd // LOCUS NP_013604 1655 aa linear PLN 30-JUN-2025 DEFINITION Nup188p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013604 VERSION NP_013604.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182465.1 REFERENCE 1 (residues 1 to 1655) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1655) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1655) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1655) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09795. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1655 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1655 /product="Nup188p" /calculated_mol_wt="188447" Region 39..976 /region_name="Nup188" /note="Nucleoporin subcomplex protein binding to Pom34; pfam10487" /db_xref="CDD:463110" Region <1407..>1498 /region_name="Nup188_C" /note="Nuclear pore protein NUP188 C-terminal domain; pfam18378" /db_xref="CDD:436451" CDS 1..1655 /gene="NUP188" /locus_tag="YML103C" /coded_by="NM_001182465.1:1..4968" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0044611 nuclear pore inner ring [PMID:18046406]" /experiment="EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:16361228]" /experiment="EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:8682855]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:16361228|PMID:8682855]" /experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:8682855]" /experiment="EXISTENCE:mutant phenotype:GO:0031990 mRNA export from nucleus in response to heat stress [PMID:18258809]" /note="Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188" /db_xref="GeneID:854868" /db_xref="SGD:S000004571" ORIGIN 1 matpsfgnss pqltfthvan fmndaaadvs avdakqlaqi rqflkanktn lieslntirq 61 nvtssgdhnk lrstianllq invdndpffa qsedlshave ffmserssrl hivysllvnp 121 didletysfi dndrfnvvgk lisiissviq nydiitassl ahdynndqdm ftivslvqlk 181 kfsdlkfilq ilqilnlmil ntkvpvdivn qwflqyqnqf vefcrninst dksidtsslq 241 lykfqnfqdl sylsetlisr isslftitti lilglntsia qfdiqsplym dtetfdtvns 301 alendvatni vnedpifhpm ihyswsfily yrralqsses fddsditkfa lfaeshdvlq 361 klntlseils fdpvyttvit vflefslnfi pitastsrvf akiiskapeq fienfltndt 421 fekklsiika klpllnesli plinlalidt efanfelkdi csfavtkssl ndldydliad 481 titnsssssd iivpdlielk sdllvapple nensncllsi pkstkgkilt ikqqqqqqqq 541 qngqqpptts nliiflykfn gwslvgrilq nllhsymekg tqlddlqhel misiiklvtn 601 vvdpktsiek sseilsylsn sldtsastin gasiiqvife ifeislqrkd ytsivqccef 661 mtmltpnylh lvssylnksd lldkygktgl snmilgsvel stgdytftiq llkltkvfir 721 eslslknihi skrskidiin klilhaihif esyynwkynn flqkfeiafh ltlifydvlh 781 dvftinphqk dqliisssan kllqlfltpm dsidlapntl tnilisplnt ttkilgdkil 841 gnlyskvmnn sfklctllia irgsnrdlkp snlekllfin ssklvdvytl psyvhfkvqi 901 iellsylvea pwnddypfll sflgeaksma flkevlsdls spvqdwnllr slyiffttll 961 eskqdglsil fltgqfasnk kindessidk kssiltvlqk nsllldstpe evscklleti 1021 tyvlntwtns kifikdpkfv nsllaklkds kklfqkkenl trdetvslik kyklisrive 1081 ifalciynst dsnseilnfl nqedlfelvh hffqidgfnk tfhdelnlkf kekwpslelq 1141 sfqkiplsri nenenfgydi plldivlkad rswnepsksq tnfkeeitda slnlqyvnye 1201 istakawgal ittfvkrstv plndgfvdlv ehflklnidf gsdkqmftqi ylerielsfy 1261 ilysfklsgk llkeekiiel mnkiftifks geidfiknig kslknnfyrp llrsvlvlle 1321 lvssgdrfie lisdqlleff elvfskgvyl ilseilcqin kcstrglstd httqivnled 1381 ntqdllllls lfkkitnvnp sknfnvilas slnevgtlkv ilnlyssahl irindepilg 1441 qitltfisel csiepiaakl insglysvll esplsvaiqq gdikpefspr lhniwsngll 1501 sivllllsqf gikvlpetcl fvsyfgkqik stiynwgdnk lavssslike tnqlvllqkm 1561 lnllnyqelf iqpknsddqq eavelvigld sehdkkrlsa alskflthpk ylnsriiptt 1621 leeqqqlede ssrlefvkgi srdikalqds lfkdv // LOCUS NP_013605 468 aa linear PLN 30-JUN-2025 DEFINITION Cac2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013605 VERSION NP_013605.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182464.1 REFERENCE 1 (residues 1 to 468) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 468) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 468) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 468) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09796. Method: conceptual translation. FEATURES Location/Qualifiers source 1..468 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..468 /product="Cac2p" /calculated_mol_wt="51121" Region <13..214 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 17..69 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 70..395 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(70,88,92,98..99,138..139,162,166,172..173,185..186, 203,208,214..215,252,273,279..280,301,305,314..315,347,352, 357..358,370,372,390,394) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 74..141 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 149..184 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 190..252 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 335..368 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 376..402 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..468 /gene="CAC2" /locus_tag="YML102W" /coded_by="NM_001182464.1:1..1407" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:11782447]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006335 DNA replication-dependent chromatin assembly [PMID:9030687]" /experiment="EXISTENCE:direct assay:GO:0033186 CAF-1 complex [PMID:9030687]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:16503640]" /experiment="EXISTENCE:mutant phenotype:GO:0006335 DNA replication-dependent chromatin assembly [PMID:9030687]" /note="Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure, deactivation of the DNA damage checkpoint after DNA repair, chromatin dynamics during transcription; and repression of divergent transcription; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:854869" /db_xref="SGD:S000004570" ORIGIN 1 meashlqiyw hdsqpvyslt fqknsandkl ftaggdnkvr iwklnrdeng qnggvrkies 61 ldflgslthh eqainvirfn skgdvlasag ddgqvllwkq edpntqqesv vrpfgmdaet 121 seadenkekw vvwkrlrggs gataaaeiyd lawspdnrni vvacmdnsir lfdvgagmlv 181 cgqsdhghyv qgvawdplnq filsqsadrs lhvygvilss agvvtglklr skiakaelpc 241 pgdvlrtnyl fhnetlpsff rrcsispcgg lvvipsgvyk vagdevancv yvytrsgiln 301 saggvknrpa iripslkkpa lmaafspvfy etcqksvlkl pyklvfaiat tnevlvydtd 361 vleplcvvgn ihyspitdla wsedgstlli sstdgfcsyv sidtetqfgs rieppamhae 421 pldtdesava aknqreaggi vnmlpvkkip cnssdskkrr ihptpvdl // LOCUS NP_013607 117 aa linear PLN 30-JUN-2025 DEFINITION Cue4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013607 VERSION NP_013607.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182462.1 REFERENCE 1 (residues 1 to 117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 117) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09797. Method: conceptual translation. FEATURES Location/Qualifiers source 1..117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..117 /product="Cue4p" /calculated_mol_wt="12762" Region 77..112 /region_name="CUE_Cue1p_like" /note="CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar proteins; cd14424" /db_xref="CDD:270607" CDS 1..117 /gene="CUE4" /locus_tag="YML101C" /coded_by="NM_001182462.1:1..354" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /note="hypothetical protein; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication" /db_xref="GeneID:854871" /db_xref="SGD:S000004568" ORIGIN 1 mdgstivfil tmvclfvytv khrgakqvps rtvqdakpap svatndpspe pvpsapeerv 61 arlnrhgsdr kravnsdmve ivmtmaphvp qekvvqdlrn tgsiehtmen ifagkld // LOCUS NP_878138 57 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML100W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878138 VERSION NP_878138.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184612.1 REFERENCE 1 (residues 1 to 57) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 57) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 57) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 57) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 57) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09798. Method: conceptual translation. FEATURES Location/Qualifiers source 1..57 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..57 /product="uncharacterized protein" /calculated_mol_wt="6116" CDS 1..57 /locus_tag="YML100W-A" /coded_by="NM_001184612.1:1..174" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466496" /db_xref="SGD:S000028688" ORIGIN 1 mykcvpsyys kagtivvtyc eisallvslk nrvqgkrget egqieisrka ghpapaf // LOCUS NP_013608 1098 aa linear PLN 30-JUN-2025 DEFINITION trehalose 6-phosphate synthase/phosphatase complex subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_013608 VERSION NP_013608.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182460.1 REFERENCE 1 (residues 1 to 1098) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1098) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1098) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1098) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1098) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1098) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1098) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09799. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1098 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1098 /product="trehalose 6-phosphate synthase/phosphatase complex subunit" /calculated_mol_wt="122887" Region 317..798 /region_name="Glyco_transf_20" /note="Glycosyltransferase family 20; pfam00982" /db_xref="CDD:425972" Region 819..1054 /region_name="Trehalose_PPase" /note="Trehalose-phosphatase; pfam02358" /db_xref="CDD:426737" CDS 1..1098 /gene="TSL1" /locus_tag="YML100W" /coded_by="NM_001182460.1:1..3297" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:8404905]" /experiment="EXISTENCE:genetic interaction:GO:0004805 trehalose-phosphatase activity [PMID:9837904]" /experiment="EXISTENCE:mutant phenotype:GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [PMID:9837904]" /experiment="EXISTENCE:mutant phenotype:GO:0004805 trehalose-phosphatase activity [PMID:9837904]" /experiment="EXISTENCE:mutant phenotype:GO:0005992 trehalose biosynthetic process [PMID:9837904]" /experiment="EXISTENCE:physical interaction:GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [PMID:9837904]" /note="Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication" /db_xref="GeneID:854872" /db_xref="SGD:S000004566" ORIGIN 1 malivaslfl pyqpqfeldt slpensqvds slvniqaman dqqqqralsn nisqeslvap 61 apeqgvppai srsatrspsa fnrassttnt atlddlvssd ifmenltana ttshtptskt 121 mlkprkngsv erffspssni ptdriaspiq hehdsgsria spiqqqqqdp ttnllknvnk 181 sllvhsllnn tsqtslegpn nhivtpksra gnrptsaats lvnrtkqgsa ssgssgssap 241 psikritphl tasaakqrpl lakqpsnlky seladissse tssqhnesdp ddlttapdee 301 yvsdlemdda kqdykvpkfg gysnksklkk yallrssqel fsrlpwsivp sikgngamkn 361 aintavleni iphrhvkwvg tvgiptdeip enilanisds lkdkydsypv ltdddtfkaa 421 yknyckqilw ptlhyqipdn pnskafedhs wkfyrnlnqr fadaivkiyk kgdtiwihdy 481 hlmlvpqmvr dvlpfakigf tlhvsfpsse vfrclaqrek ilegltgadf vgfqtreyar 541 hflqtsnrll madvvhdeel kyngrvvsvr ftpvgidafd lqsqlkdgsv mqwrqlirer 601 wqgkklivcr dqfdrirgih kkllayekfl venpeyveks tliqicigss kdvelerqim 661 ivvdrinsls tnisisqpvv flhqdldfsq ylalsseadl fvvsslregm nltchefivc 721 sedknaplll seftgsasll ndgaiiinpw dtknfsqail kglempfdkr rpqwkklmkd 781 iinndstnwi ktslqdihis wqfnqegski fklntktlme dyqsskkrmf vfniaeppss 841 rmisilndmt skgnivyimn sfpkpilenl ysrvqnigli aengayvsln gvwynivdqv 901 dwrndvakil edkverlpgs yykinesmik fhtenaedqd rvasvigdai thintvfdhr 961 gihayvyknv vsvqqvglsl saaqflfrfy nsasdpldts sgqitniqtp sqqnpsdqeq 1021 qppasptvsm nhidfacvsg ssspvleplf klvndeaseg qvkaghaivy gdatstyake 1081 hvnglnelft iisriied // LOCUS NP_013610 880 aa linear PLN 30-JUN-2025 DEFINITION Arg81p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013610 VERSION NP_013610.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182459.1 REFERENCE 1 (residues 1 to 880) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 880) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 880) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 880) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 880) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09800. Method: conceptual translation. FEATURES Location/Qualifiers source 1..880 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..880 /product="Arg81p" /calculated_mol_wt="100151" Site order(16,20,25..28,30,33,43) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Region 19..58 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(21,24,31,38,41,48) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 395..878 /region_name="Fungal_trans_2" /note="Fungal specific transcription factor domain; pfam11951" /db_xref="CDD:403235" CDS 1..880 /gene="ARG81" /locus_tag="YML099C" /gene_synonym="ARGR2" /coded_by="NM_001182459.1:1..2643" /experiment="EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:10688655]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:3311884]" /experiment="EXISTENCE:mutant phenotype:GO:0000821 regulation of arginine metabolic process [PMID:10688655]" /note="Zinc finger transcription factor involved in arginine-responsive genes; Zn(2)-Cys(6) binuclear cluster domain type; involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p" /db_xref="GeneID:854874" /db_xref="SGD:S000004565" ORIGIN 1 mgisskngpk kmgraktftg cwtcrgrkvk cdlrhphcqr ceksnlpcgg ydiklrwskp 61 mqfdpygvpi pqnspatttn lsgsvdepqy qrrnidfvry deeyvyhedm ddeltmlhtp 121 piekisdnkt wiikkfgvfk gtdkidkqya prkkrnrkrv akslessasi slsslpssst 181 isfpirhied klrnkghvkt gilsandgvp ptpnlldydw nnlnitgyew isselrddal 241 lsavtlqghh lghtqpqeis leensnvvsg eehvnakehg cafeadnqgs stlpnkaasa 301 ndklyqqnlk llfqknssns eepdpqalid dvfvnieprs lpasdlnkit lappneesrm 361 pksmleltsy ssdlppelvd iipktdltvh glarfllnhy fnnvadkmtv vvleknpwkt 421 lyfpralmal gdlaglgqss nsrnallnal lavscfhlqs kyprnyklqk yflglgielr 481 nqasnflrlc lntkssipek ykdvltails mnsidvvwgt madcqdhlal cedfvesrmk 541 lrpnisektk tlhrifsflk liqdstaldk vrakeivilp seeddnykpl dtsnattsss 601 eprvdvvqeg lfrealnend gkihiefvke pitnvsadst pssttppift niatesyynk 661 sdisklvskt deniigtdsl yglpnslill fsdcvrivrh neyynltylp vprkfnelsl 721 nfekrllkwk sewnfhqens egksfinsta ealyhhtmsf yfsliiyyft marslncqfl 781 qnyvakvldh lnameelvdq kkvkivpliw qgfmagcact denrqqefrr waaklaesgv 841 gsywgarqvm levwrrrked epgdnwysvy kdwemnlmls // LOCUS NP_013611 167 aa linear PLN 30-JUN-2025 DEFINITION Taf13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013611 VERSION NP_013611.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182458.1 REFERENCE 1 (residues 1 to 167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 167) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09801. Method: conceptual translation. FEATURES Location/Qualifiers source 1..167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..167 /product="Taf13p" /calculated_mol_wt="19001" Region 1..133 /region_name="TAF19" /note="Transcription initiation factor TFIID, subunit TAF13 [Transcription]; COG5248" /db_xref="CDD:227573" Site order(11,14..15,17..24,28..29,31..32,35..36,38..49,52) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467023" CDS 1..167 /gene="TAF13" /locus_tag="YML098W" /gene_synonym="FUN81; TAF19" /coded_by="NM_001182458.1:1..504" /experiment="EXISTENCE:curator inference:GO:0016251 RNA polymerase II general transcription initiation factor activity []" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]" /note="TFIID subunit (19 kDa); involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors" /db_xref="GeneID:854875" /db_xref="SGD:S000004564" ORIGIN 1 msrklkktnl fnkdvsslly aygdvpqplq atvqcldelv sgylvdvctn afhtaqnsqr 61 nklrledfkf alrkdpiklg raeeliatnk liteakkqfn etdnqnslkr yreedeegde 121 meededeqqv tdddeeaagr nsakqstdsk atkirkqgpk nlkktkk // LOCUS NP_013612 451 aa linear PLN 30-JUN-2025 DEFINITION guanine nucleotide exchange factor VPS9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013612 VERSION NP_013612.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182457.1 REFERENCE 1 (residues 1 to 451) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 451) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 451) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 451) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09802. Method: conceptual translation. FEATURES Location/Qualifiers source 1..451 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..451 /product="guanine nucleotide exchange factor VPS9" /calculated_mol_wt="52352" Region 80..146 /region_name="DUF5601" /note="Domain of unknown function (DUF5601); pfam18151" /db_xref="CDD:465668" Region 205..321 /region_name="VPS9" /note="Domain present in VPS9; smart00167" /db_xref="CDD:128469" Region 408..449 /region_name="CUE_VPS9_like" /note="CUE domain found in vacuolar protein sorting-associated protein 9 (VPS9) and similar proteins; cd14369" /db_xref="CDD:270552" Site order(408,412,414..416,418..420,423,427,431..432,435..437, 441..443) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270552" CDS 1..451 /gene="VPS9" /locus_tag="YML097C" /gene_synonym="VPL31; VPT9" /coded_by="NM_001182457.1:1..1356" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:23612966|PMID:10329739]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:31754649]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:23612966|PMID:8628304|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12628920]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:23612966]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:23612966]" /experiment="EXISTENCE:genetic interaction:GO:0036010 protein localization to endosome [PMID:23264632]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8628304]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:23612966|PMID:22748138]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:23612966]" /note="Guanine nucleotide exchange factor (GEF) and ubiquitin receptor; involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF MUK1; required for localization of the CORVET complex to endosomes; similar to mammalian ras inhibitors; contains a Ub-interacting CUE domain" /db_xref="GeneID:854876" /db_xref="SGD:S000004563" ORIGIN 1 mtddekreil kefdpfsqle qangnpdkdv kfkkddpnra aaeetnrdis aqdkgdeepf 61 ydfqifikql qtpgadplvk ytksflrnfl aqrllwtvse eiklisdfkt fiydkftlye 121 pfrsldnskm rnakegmekl imgklysrcf spslyeilqk plddehmkdl tnddtlleki 181 rhyrfispim ldipdtmpna rlnkfvhlas kelgkinrfk sprdkmvcvl naskvifgll 241 khtkleqnga dsfipvliyc ilkgqvrylv snvnyierfr spdfirgeee yylsslqaal 301 nfimnlters ltiedhedfe eayqrnfkql aeekeeeekk kqleipdelq pngtllkpld 361 evtniviskf nelfspigep tqeealkseq snkeedvssl ikkieenerk dtlntlqnmf 421 pdmdpslied vciakksrig pcvdallsls e // LOCUS NP_013613 525 aa linear PLN 30-JUN-2025 DEFINITION putative asparagine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013613 VERSION NP_013613.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182456.1 REFERENCE 1 (residues 1 to 525) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 525) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 525) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 525) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09803. Method: conceptual translation. FEATURES Location/Qualifiers source 1..525 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..525 /product="putative asparagine synthase" /calculated_mol_wt="59339" Region 1..191 /region_name="Gn_AT_II_novel" /note="This asparagine synthase-related domain is present in eukaryotes but its function has not yet been determined. The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is...; cd03766" /db_xref="CDD:239735" Site order(2,72,94..96,108) /site_type="active" /db_xref="CDD:239735" Region 252..500 /region_name="Asn_synthase_B_C" /note="C-terminal domain of asparagine synthase B; cd01991" /db_xref="CDD:467495" CDS 1..525 /locus_tag="YML096W" /coded_by="NM_001182456.1:1..1578" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative protein with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10" /db_xref="GeneID:854877" /db_xref="SGD:S000004562" ORIGIN 1 mcgillhycp nnnylndeli efpegtefgd ttctnessif nkiipyiaar gpnysslrav 61 kayriswfss vlslrqpftk qsinvddryf lqfngelynk eisqgdndsl yiasmlqnlk 121 egmgvidvik slegeyayti ydvnssklyf grdpigrrsl sysvtpdnel yvasvtgsag 181 sfqdciggvi yeydtrtkll nsnqrshlpy evtseidlnf tslsevsknl yavlrdsvkk 241 rvesihprhi enspiavlfs ggidcsviva licevlqend ykcgkpviel lnvsfenprt 301 glfpsdtpdr klsinsaktl qnlypnvdik lvevdvpyde ylkwkpfvin lmypkqtemd 361 lsiaiafffa srgrgfltsl ngertpyqrh givlfsglga delyggyhkf ankpphelve 421 eltrqinniy drnlnrddkv iahngvevry pfldeyvikl staeipinfk vnklilrkva 481 sqylkldgis sepkraiqfg aksakmtkdg nkhgtdllke nrncs // LOCUS NP_013614 210 aa linear PLN 30-JUN-2025 DEFINITION DNA repair protein RAD10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013614 VERSION NP_013614.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182454.1 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09804. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..210 /product="DNA repair protein RAD10" /calculated_mol_wt="24180" Region 1..210 /region_name="RAD10" /note="Nucleotide excision repair endonuclease NEF1, RAD10 subunit [DNA replication, recombination, and repair]; COG5241" /db_xref="CDD:227566" CDS 1..210 /gene="RAD10" /locus_tag="YML095C" /coded_by="NM_001182454.1:1..633" /experiment="EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:8253764]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:1741062]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9852079]" /experiment="EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:7559571]" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:11514439]" /experiment="EXISTENCE:mutant phenotype:GO:0000735 removal of nonhomologous ends [PMID:7891718]" /experiment="EXISTENCE:mutant phenotype:GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends [PMID:7891718]" /experiment="EXISTENCE:mutant phenotype:GO:0006277 DNA amplification [PMID:23271978]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:2188090]" /experiment="EXISTENCE:physical interaction:GO:0000110 nucleotide-excision repair factor 1 complex [PMID:8621533]" /note="Single-stranded DNA endonuclease (with Rad1p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein" /db_xref="GeneID:854878" /db_xref="SGD:S000004560" ORIGIN 1 mnntdptsfe silagvaklr keksgadttg sqsleidask lqqqepqtsr rinsnqvina 61 fnqqkpeewt dskatddynr krpfrstrpg ktvlvnttqk enpllnhlks tnwryvsstg 121 inmiyydylv rgrsvlfltl tyhklyvdyi srrmqplsrn ennilifivd dnnsedtlnd 181 itklcmfngf tlllafnfeq aakyieylnl // LOCUS NP_013616 163 aa linear PLN 30-JUN-2025 DEFINITION Gim5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013616 VERSION NP_013616.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182453.1 REFERENCE 1 (residues 1 to 163) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 163) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 163) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 163) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09805. Method: conceptual translation. FEATURES Location/Qualifiers source 1..163 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..163 /product="Gim5p" /calculated_mol_wt="18225" Region 15..139 /region_name="Prefoldin_5" /note="Prefoldin subunit 5; cd23157" /db_xref="CDD:467473" Region 15..54 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467473" Site order(43,46..47,50..51,53..54,62..69,71..80,83..87,91..96, 105) /site_type="other" /note="prefoldin oligomer interface [polypeptide binding]" /db_xref="CDD:467473" Region 99..139 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467473" CDS 1..163 /gene="GIM5" /locus_tag="YML094W" /gene_synonym="PFD5" /coded_by="NM_001182453.1:1..492" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9463374]" /experiment="EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:9463374]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9463374]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:physical interaction:GO:0016272 prefoldin complex [PMID:9463374]" /note="Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation" /db_xref="GeneID:854879" /db_xref="SGD:S000004559" ORIGIN 1 mssqkidltk lnpeqlnavk qqfdqelqhf tqslqaltma kgkftecidd iktvsqagne 61 gqkllvpasa slyipgkivd nkkfmvdigt gyyveksaea aiafyqkkvd klnkesvqiq 121 diikektqys lsieaqirqa airqheamsk qqqqqqkkes sta // LOCUS NP_013617 899 aa linear PLN 30-JUN-2025 DEFINITION Utp14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013617 VERSION NP_013617.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182452.1 REFERENCE 1 (residues 1 to 899) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 899) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 899) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 899) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 899) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09806. Method: conceptual translation. FEATURES Location/Qualifiers source 1..899 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..899 /product="Utp14p" /calculated_mol_wt="102893" Region 1..898 /region_name="COG5644" /note="U3 small nucleolar RNA-associated protein 14 [Function unknown]" /db_xref="CDD:227931" CDS 1..899 /gene="UTP14" /locus_tag="YML093W" /coded_by="NM_001182452.1:1..2700" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:26729466]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:26729466]" /note="Subunit of U3-containing Small Subunit (SSU) processome complex; involved in production of 18S rRNA and assembly of small ribosomal subunit; activates the RNA helicase Ecm16p to dislodge the U3 snoRNA and along with Bud23p recruits the helicase to the assembling preribosome dislodging U3 snRNA" /db_xref="GeneID:854881" /db_xref="SGD:S000004558" ORIGIN 1 makkksksrs kssrrvldal qlaereinge fdnssdndkr hdarrngtvv nllkrskgdt 61 nsdeddidse sfedeelnsd ealgsdddyd ilnskfsqti rdkkenanyq eeedeggyts 121 ideedlmpls qvwdmdekta qsngnddeda spqlklqdtd issessssee seseseddee 181 eedpfdeise deedielnti tsklidetks kapkrldtyg sgeaneyvlp sanaasgasg 241 klsltdmmnv iddrqviena nllkgkssty evplpqriqq rhdrkaayei srqevskwnd 301 ivqqnrradh lifplnkpte hnhasaftrt qdvpqtelqe kvdqvlqesn lanpekdskf 361 eelstakmtp eemrkrttem rlmrelmfre erkarrlkki ksktyrkikk kelmknrela 421 avssdedned hdiarakerm tlkhktnskw akdmikhgmt ndaetreeme emlrqgerlk 481 akmldrnsdd eedgrvqtls dveneekeni dsealksklg ktgvmnmafm kngearerea 541 nketlrqlra vengddiklf esdeeetnge niqinkgrri ytpgslesnk dmnelndhtr 601 kenkvdesrs lenrlrakns gqsknartna egaiiveees dgeplqdgqn nqqdeeakdv 661 npwlanesde ehtvkkqssk vnvidkdssk nvkamnkmek aelkqkkkkk gksnddedll 721 ltaddstrlk ivdpyggsdd eqgdnvfmfk qqdviaeafa gddvvaefqe ekkrvidded 781 dkevdttlpg wgewagagsk pknkkrkfik kvkgvvnkdk rrdknlqnvi inekvnkknl 841 kyqssavpfp fenreqyers lrmpigqewt srashqelik primtkpgqv idplkapfk // LOCUS NP_013618 250 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit alpha 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013618 VERSION NP_013618.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182451.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09807. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..250 /product="proteasome core particle subunit alpha 2" /calculated_mol_wt="27031" Region 5..247 /region_name="proteasome_alpha_type_2" /note="The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming...; cd03750" /db_xref="CDD:239719" Site order(7..10,12..13,15..16,20,23,26..27,30,38,53,55..56, 79..81,83..84,116,119,122..123,126..130,148,153..154,156, 158..159,161) /site_type="other" /note="alpha subunit interaction site [polypeptide binding]" /db_xref="CDD:239719" Site order(32,48,50,63,166) /site_type="active" /db_xref="CDD:239719" CDS 1..250 /gene="PRE8" /locus_tag="YML092C" /coded_by="NM_001182451.1:1..753" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019773 proteasome core complex, alpha-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:19029916|PMID:11545745]" /note="Alpha 2 subunit of the 20S proteasome" /db_xref="GeneID:854882" /db_xref="SGD:S000004557" ORIGIN 1 mtdrysfslt tfspsgklgq idyaltavkq gvtslgikat ngvviatekk sssplamset 61 lskvslltpd igavysgmgp dyrvlvdksr kvahtsykri ygeypptkll vsevakimqe 121 atqsggvrpf gvslliaghd efngfslyqv dpsgsyfpwk ataigkgsva aktflekrwn 181 deleledaih ialltlkesv egefngdtie laiigdenpd llgytgiptd kgprfrklts 241 qeindrleal // LOCUS NP_013619 1202 aa linear PLN 30-JUN-2025 DEFINITION ribonuclease P [Saccharomyces cerevisiae S288C]. ACCESSION NP_013619 VERSION NP_013619.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182450.1 REFERENCE 1 (residues 1 to 1202) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1202) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1202) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1202) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09808. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1202 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1202 /product="ribonuclease P" /EC_number="3.1.26.5" /calculated_mol_wt="139218" Region 163..281 /region_name="RPM2" /note="Mitochondrial ribonuclease P subunit (RPM2); pfam08579" /db_xref="CDD:369970" Region 194..216 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 222..259 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" CDS 1..1202 /gene="RPM2" /locus_tag="YML091C" /coded_by="NM_001182450.1:1..3609" /experiment="EXISTENCE:direct assay:GO:0001682 tRNA 5'-leader removal [PMID:8366116]" /experiment="EXISTENCE:direct assay:GO:0004526 ribonuclease P activity [PMID:8366116]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16024791]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:7544434]" /experiment="EXISTENCE:direct assay:GO:0030677 ribonuclease P complex [PMID:8366116]" /experiment="EXISTENCE:direct assay:GO:0030678 mitochondrial ribonuclease P complex [PMID:3537697]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16024791]" /experiment="EXISTENCE:genetic interaction:GO:0006397 mRNA processing [PMID:17267405]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:11404323]" /experiment="EXISTENCE:mutant phenotype:GO:0006396 RNA processing [PMID:11522833]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11404323]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16024791]" /experiment="EXISTENCE:mutant phenotype:GO:0097745 mitochondrial tRNA 5'-end processing [PMID:30759361]" /experiment="EXISTENCE:physical interaction:GO:0006397 mRNA processing [PMID:17267405]" /note="Protein subunit of mitochondrial RNase P; has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus" /db_xref="GeneID:854883" /db_xref="SGD:S000004556" ORIGIN 1 mafksfiysk gyhrsaaqkk tatsffdssy qylrqnqglv nsdpvlhash lhphpvvvan 61 vnynnvddil hphdldssin ntnnplthee llynqnvslr slkqqqstny vnnnnnnqhr 121 yystgptlpt nqydplnfsn rnfqdlslkt sqpsvqqpqn eysllkdena pvwkedtepc 181 lnkstylqth ideinrcyeq knynkinsly qslkrndivp pleiftkvld slckrpldnn 241 dldnkmyell tcyqdminnr lkppdeiyni vllslfkgsi layqfenpng sdfykiaiel 301 fntttndpkq ksvvkfrnfs kdvldynlla mniypghitl skaqqvikss pafikdsfyf 361 iacfsyaklt ndkfaikely edfrlslssg spdqglfddq feiysvilss fietgevela 421 tnllddlvsk iqssnglasn islllssfli smskvdpska yeiwfkfhnl nwipefsyef 481 ylvfmansfq dwnltkkiyd yifpmernls plkkqklsdy llhpigvdsi ttslldyslq 541 lkdnevimki leesivknfs fdigiypfvf nylreiqcge dylmrfiesh aefikksnsi 601 nkfqflnmiv dnfqsqslln kishakffkn fvedfnlenc elvsynglis cinnfikipk 661 tikdfpyile ihailvtklf dfdtypilqn gnnevllkfr dqiehqfkml aqnfcrlnld 721 pnllagvvsq amkmvnlddt angqdllnff nhpgdwdksy plslgsfirn sprggireft 781 klskegycfd ydtykeliik rainkqiidk clevcpdsie lknivnlmis kipgrnltql 841 iinnpkfskv fvpnlrndsm lkliencesl snfiricdfp ekfksiaiqa enknaieliy 901 erlfdggkya dilrynnivp vlnlelllks cirsgefkky eslskkfndk isesskidiq 961 leylinkndl kgaftlfekt prelrtphkt mdlytfalfl dsfnrnityy espentlqfa 1021 nilssqtsfi nllstynlia hsdhlmnfnv ggmaakvkke ilnqmlnnly dsirllspsi 1081 endksmkekl rekvknycrf kaylkspeld mdelktlvsv esflnpftps mlfnnlieti 1141 yinehasslv lqngliyslq qkglnkilsy leesfitsgn daniekvref rsllrkskpl 1201 qa // LOCUS NP_013622 668 aa linear PLN 30-JUN-2025 DEFINITION SCF ubiquitin ligase complex subunit UFO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013622 VERSION NP_013622.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182447.1 REFERENCE 1 (residues 1 to 668) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 668) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 668) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 668) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 668) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09809. Method: conceptual translation. FEATURES Location/Qualifiers source 1..668 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..668 /product="SCF ubiquitin ligase complex subunit UFO1" /calculated_mol_wt="76729" Region 6..46 /region_name="F-box_ScUFO1-like" /note="F-box domain found in Saccharomyces cerevisiae ubiquitin ligase complex F-box protein UFO1 (ScUFO1) and similar proteins; cd22145" /db_xref="CDD:438916" Site order(11,15,18..19,22..23,27,29..30,34..36,38) /site_type="other" /note="putative Skp1 binding site [polypeptide binding]" /db_xref="CDD:438916" CDS 1..668 /gene="UFO1" /locus_tag="YML088W" /coded_by="NM_001182447.1:1..2007" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14506225]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:14506225]" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:11283612|PMID:14747994]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:10963670]" /experiment="EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:10963670]" /experiment="EXISTENCE:mutant phenotype:GO:0071406 cellular response to methylmercury [PMID:17141224]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994|PMID:14506225]" /experiment="EXISTENCE:physical interaction:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:14506225]" /note="F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitination by SCF and subsequent degradation" /db_xref="GeneID:854886" /db_xref="SGD:S000004553" ORIGIN 1 merpglvlqd lppeilinif shldekdlft lqelsthfrn lihdeelwkn lfksrvhtth 61 fptfsqsskf sveyiertrg lhhwqhnkai rtkytiiptr nwdqpsieri vfdyprvaay 121 ndgtitilql qnhkrqkkfk kliyipcttp qgcstmdfni naavfgrfdg rvfgkllsnk 181 syltpvmeft grhsagvtai cnseswdtsr edwsvsgsen geiiwwcenk lvkmwkvsnr 241 viwklaffkd wtlimddekl yiihqmqelh sidipkdlde qpmrvrffkm dfgsmtlvla 301 dlnnvytisv npngnfgnlr klempeqica veidektsqr eqnwqfagdd gcyisllttq 361 ntlyiinird lsssglkvqc kisfdeqvyv sqvtnlivvv alpnvlqiln amtgeliktv 421 lktekfpefl kvsqdkiimg sgnvlnylkf vssdskkhhh stkgkntvsn kwnetlntel 481 qyydededlr rkrqseisrl idayggdlel sgdtdeendi qlriallesq eaqarnqaea 541 gepvgddede qlrraleesq liyetqtnss anhgnntnde ideddeeflr airqsrvede 601 rrrhlrnhtt grrngplsdd nfatygaaes sertstenti gssvgvdasn nvdedlqlai 661 alslsein // LOCUS NP_013623 312 aa linear PLN 30-JUN-2025 DEFINITION cytochrome-b5 reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013623 VERSION NP_013623.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182446.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09810. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..312 /product="cytochrome-b5 reductase" /calculated_mol_wt="35633" Region 75..312 /region_name="cyt_b5_reduct_like" /note="Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a...; cd06183" /db_xref="CDD:99780" Site order(108,122..125,139..141,143,145..149,187,190..191,312) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99780" Site order(122,124..125) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99780" Site order(141,143,187..188,214..216,244,256,279..283) /site_type="other" /note="NAD binding pocket [chemical binding]" /db_xref="CDD:99780" Site order(146,149,152,158,166,168) /site_type="other" /note="phosphate binding motif [ion binding]" /db_xref="CDD:99780" Site order(182,186..189,191) /site_type="other" /note="beta-alpha-beta structure motif" /db_xref="CDD:99780" CDS 1..312 /gene="AIM33" /locus_tag="YML087C" /coded_by="NM_001182446.1:1..939" /note="hypothetical protein, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication" /db_xref="GeneID:854887" /db_xref="SGD:S000004552" ORIGIN 1 msivetcisf vstnpfypfc tglllncvvt plyfwktqng rivvvsllqf vvlyatafis 61 igtdkslyrn kwvalplskk trisrntsly cfklkypfer lhipmgyhla vrvtingerl 121 vryytpvnvp nteghlelvv ktykhgvvsk yfdklkirqy vefkgplgel eydqdtatel 181 giiaggsgit pvlqvlqeii pspedlthis liyanetedd ilmksqldhm akeyphfkvh 241 yvihkpngkw ngdvgyvtle emkrylpkqa edhrllicgp pkmnemvlny akelgwsngf 301 hkgngtdkvf vf // LOCUS NP_013624 526 aa linear PLN 30-JUN-2025 DEFINITION D-arabinono-1,4-lactone oxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013624 VERSION NP_013624.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182445.1 REFERENCE 1 (residues 1 to 526) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 526) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 526) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 526) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09811. Method: conceptual translation. FEATURES Location/Qualifiers source 1..526 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..526 /product="D-arabinono-1,4-lactone oxidase" /EC_number="1.1.3.37" /calculated_mol_wt="59363" Region 9..509 /region_name="FAD_lactone_ox" /note="sugar 1,4-lactone oxidases; TIGR01678" /db_xref="CDD:273751" CDS 1..526 /gene="ALO1" /locus_tag="YML086C" /coded_by="NM_001182445.1:1..1581" /experiment="EXISTENCE:direct assay:GO:0003885 D-arabinono-1,4-lactone oxidase activity [PMID:10094636]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:10094636|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16689936|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0032473 cytoplasmic side of mitochondrial outer membrane [PMID:39775849]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:39775849]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:39775849]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:39775849|PMID:10094636]" /experiment="EXISTENCE:mutant phenotype:GO:0070485 dehydro-D-arabinono-1,4-lactone biosynthetic process [PMID:10094636]" /experiment="EXISTENCE:physical interaction:GO:0031489 myosin V binding [PMID:39775849]" /note="D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress; putative adaptor protein that interacts with the cargo-binding domain of Myo2p and has a role in mitochondrial inheritance, especially under conditions of oxidative stress; localizes to the mitochondrial outer membrane; null mutant shows improved noncanonical amino acid incorporation efficiency in response to the amber (TAG) stop codon" /db_xref="GeneID:854888" /db_xref="SGD:S000004551" ORIGIN 1 mstipfrkny vfknwagiys akperyfqps sidevvelvk sarlaekslv tvgsghspsn 61 mcvtdewlvn ldrldkvqkf veypelhyad vtvdagmrly qlneflgakg ysiqnlgsis 121 eqsvagiist gshgsspyhg lissqyvnlt ivngkgelkf ldaendpevf kaallsvgki 181 giivsatirv vpgfnikstq evitfenllk qwdtlwtsse firvwwypyt rkcvlwrgnk 241 ttdaqngpak swwgtklgrf fyetllwist kiyapltpfv ekfvfnrqyg kleksstgdv 301 nvtdsisgfn mdclfsqfvd ewgcpmdngl evlrsldhsi aqaainkefy vhvpmevrcs 361 nttlpsepld tskrtntspg pvygnvcrpf ldntpshcrf aplenvtnsq ltlyinatiy 421 rpfgcntpih kwftlfentm mvaggkphwa knflgsttla agpvkkdtdy ddfemrgmal 481 kveewygedl kkfrkirkeq dpdnvflank qwaiingiid pselsd // LOCUS NP_013625 447 aa linear PLN 30-JUN-2025 DEFINITION alpha-tubulin TUB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013625 VERSION NP_013625.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182444.1 REFERENCE 1 (residues 1 to 447) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 447) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 447) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 447) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09812. Method: conceptual translation. FEATURES Location/Qualifiers source 1..447 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..447 /product="alpha-tubulin TUB1" /calculated_mol_wt="49669" Region 2..436 /region_name="alpha_tubulin" /note="The alpha-tubulin family; cd02186" /db_xref="CDD:276955" Site order(2,200,254..255,257..259,261..262,327,353) /site_type="other" /note="beta/alpha domain interface [polypeptide binding]" /db_xref="CDD:276955" Site order(11..12,15,72,102,144..147,172,207,225,229) /site_type="other" /note="nucleotide binding site [chemical binding]" /db_xref="CDD:276955" Site order(73..74,101..103,106,182,184,225) /site_type="other" /note="alpha/beta domain interface [polypeptide binding]" /db_xref="CDD:276955" CDS 1..447 /gene="TUB1" /locus_tag="YML085C" /coded_by="NM_001182444.1:1..1344" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0045298 tubulin complex [PMID:9488492]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:16582437]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:16582437]" /experiment="EXISTENCE:mutant phenotype:GO:0045143 homologous chromosome segregation [PMID:16582437]" /experiment="EXISTENCE:physical interaction:GO:0045298 tubulin complex [PMID:9488492]" /note="Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; relative distribution to nuclear foci increases upon DNA replication stress; TUB1 has a paralog, TUB3, that arose from the whole genome duplication" /db_xref="GeneID:854889" /db_xref="SGD:S000004550" ORIGIN 1 mrevisinvg qagcqignac welyslehgi kpdghledgl skpkggeegf stffhetgyg 61 kfvpraiyvd lepnvidevr ngpykdlfhp eqlisgkeda annyarghyt vgreilgdvl 121 drirkladqc dglqgflfth slgggtgsgl gsllleelsa eygkksklef avypapqvst 181 svvepyntvl tthttlehad ctfmvdneai ydmckrnldi prpsfanlnn liaqvvssvt 241 aslrfdgsln vdlnefqtnl vpyprihfpl vsyspvlsks kafhesnsvs eitnacfepg 301 nqmvkcdprd gkymatclly rgdvvtrdvq raveqvknkk tvqlvdwcpt gfkigicyep 361 ptatpnsqla tvdravcmls nttsiaeawk ridrkfdlmy akrafvhwyv gegmeegeft 421 earedlaale rdyievgads yaeeeef // LOCUS NP_013627 418 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML083C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013627 VERSION NP_013627.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182442.1 REFERENCE 1 (residues 1 to 418) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 418) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 418) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 418) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09813. Method: conceptual translation. FEATURES Location/Qualifiers source 1..418 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..418 /product="uncharacterized protein" /calculated_mol_wt="47219" Region <11..>135 /region_name="PHA03378" /note="EBNA-3B; Provisional" /db_xref="CDD:223065" CDS 1..418 /locus_tag="YML083C" /coded_by="NM_001182442.1:1..1257" /note="hypothetical protein; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions" /db_xref="GeneID:854891" /db_xref="SGD:S000004548" ORIGIN 1 mdylhvynnn qahvprtppg rqclspvlpp iilaldqqhs ltfgyssprc lptpilpsms 61 tntpvhwsqq vvtipvavrn haammpiitp mtsprpqfea tapspplapv aiklpdlklp 121 pspvpstved rvshpilpki vigngggrdv erdsteelir kipnyigcak tkaqlskvrs 181 gkqliacaqe yhhpvnkdei eninnilnfr dfifkhpkss feflctlsfe qfvrvysfis 241 fiyrtkkink nkyelvcemn vheqlsnkri qrtrtpekyk ihliceskli ltfnhctktv 301 kfesingghc hpisanhiik pslflthcin kcyqtvsdpt dlklalrdal ealdherigl 361 sflkrrhfkc shqasslsna satlkkqedh dtfgvhtgii htanffmfna ssdifqrn // LOCUS NP_013628 649 aa linear PLN 30-JUN-2025 DEFINITION putative cystathionine gamma-synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013628 VERSION NP_013628.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182441.1 REFERENCE 1 (residues 1 to 649) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 649) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 649) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 649) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 649) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09814. Method: conceptual translation. FEATURES Location/Qualifiers source 1..649 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..649 /product="putative cystathionine gamma-synthase" /EC_number="2.5.1.48" /calculated_mol_wt="74183" Region <310..>464 /region_name="AAT_I" /note="Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl18945" /db_xref="CDD:450240" Site order(311..312,315,398,427,430,448,451) /site_type="other" /note="pyridoxal 5'-phosphate binding pocket [chemical binding]" /db_xref="CDD:99738" Region <394..645 /region_name="AAT_I" /note="Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl18945" /db_xref="CDD:450240" Site 451 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99738" CDS 1..649 /locus_tag="YML082W" /coded_by="NM_001182441.1:1..1950" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; not an essential gene; YML082W has a paralog, STR2, that arose from the whole genome duplication" /db_xref="GeneID:854892" /db_xref="SGD:S000004547" ORIGIN 1 mvsaqvatel gqpipldtqh avsvcfptwk svisyvekdp kvlgclksgy prfwihpsiq 61 klrdilieky akenetcfcf psyrvakrcr eyvrrkcahr ngkvrilqla takpineeqk 121 twkreckiav vfvdgayeni lkqywqytge iissrlaeyv lhelfmvekk sspaeekeyi 181 emrygrnlnf afadrakeli kkriatkvid kdehdeeeny hflagnqdeq dfqdtfldss 241 lneanhgedh dggisgevds qeephnglvs tippepiems tieeeqsvee dagrcalrvc 301 perdvflfps gmasiftahr lllqwdslrl nrsrngsdvt ssppnkktvi fgfpyadtlh 361 vlqefnetyf lgegdessmk eltkilhsge qilavfietp snpllkmgnl lelkrlself 421 gffiiidetv ggivnidglp fadivcsslt ktfsgdsnvi ggsmvlnpqs rvyefasrfm 481 qledeyedll wcedaiyler nsrdfiarti rinysteyll dkilkphvge nklfkkiyyp 541 nltsketltn ydmvrckkeg gygglfsltf hdedhaaafy dnlklnkgps lgtnftlafp 601 ytlmtyyhel dmaekfgver nllrisvgle sqsilgkifq eaidktvei // LOCUS NP_013629 59 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit i [Saccharomyces cerevisiae S288C]. ACCESSION NP_013629 VERSION NP_013629.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184340.1 REFERENCE 1 (residues 1 to 59) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 59) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 59) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 59) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09815. Method: conceptual translation. FEATURES Location/Qualifiers source 1..59 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..59 /product="F1F0 ATP synthase subunit i" /calculated_mol_wt="6557" Region 4..54 /region_name="ATP-synt_J" /note="ATP synthase j chain; pfam04911" /db_xref="CDD:428192" CDS 1..59 /gene="ATP18" /locus_tag="YML081C-A" /coded_by="NM_001184340.1:1..180" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0045259 proton-transporting ATP synthase complex [PMID:20219971]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:9867807|PMID:9867878]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:20219971]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:9867807]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:9867807]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:20219971]" /note="Subunit of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms" /db_xref="GeneID:854893" /db_xref="SGD:S000007247" ORIGIN 1 mlkrfptpil kvywpffvag aavyygmska adlssntkef indprnprfa kggkfvevd // LOCUS NP_013630 1251 aa linear PLN 30-JUN-2025 DEFINITION Tda9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013630 VERSION NP_013630.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182440.1 REFERENCE 1 (residues 1 to 1251) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1251) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1251) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1251) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09816. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1251 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1251 /product="Tda9p" /calculated_mol_wt="141335" Region 29..>235 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 63..83 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 91..112 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 665..>783 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..1251 /gene="TDA9" /locus_tag="YML081W" /gene_synonym="AAF1" /coded_by="NM_001182440.1:1..3756" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363|PMID:16785442]" /experiment="EXISTENCE:mutant phenotype:GO:0019413 acetate biosynthetic process [PMID:23240040]" /note="Transcription factor that regulates acetate production; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; TDA9 has a paralog, RSF2, that arose from the whole genome duplication" /db_xref="GeneID:854894" /db_xref="SGD:S000004546" ORIGIN 1 msseefkglp ikrdisstiy adrppalsap pcvgatgndk iqvlpipkks rtiktdkprp 61 flchictrgf vrqehlkrhq rahtnekpfl cvfcgrcfar rdlvlrhqhk lhsalvskes 121 inskdkteid aindkniiqi qgnkqtilpt psnplaktav qlkkaakekk ngkqgkldls 181 psygannhst dvspsvgnss tpavieetds sshfplpdtn iptkskrhas fsassaftys 241 sdnfqklhqq aksdfdelqe siphqvgfst pqltaqqlie naiesgvvdl etldlppfls 301 ldglppasss aavaaseqid icpssatdti sganstpnqa atappfqlpi aressslfla 361 ntpylsdflt mgssyggsgg faksitadps ldyfnyknhs hpdsrhnnss sginysnnkn 421 nnesieksqn nsnvinetid htdihahhad ahddsfiese ewlskfimds qidndlklni 481 nhfndigfnn lhpqnptths eprnmhnenr dmhrsaskfq svsenispre qmslfktkqn 541 kaiskflsde kipstaspss saspvqfdkk nvdineflld esvsnlfttr qidlfkknvn 601 lysplfqnqk davsstsltp slttqtattq sgpgwtdssq kltffteqlr nliikennlk 661 snlfptvdel nhyvdlyqve fhkyfpfihl ysiipsseny plvisismig alygfhstha 721 lllskiartr vrmflentrs nhdktpiwlm qslvlltfts ifsndmnafr tvntqimilv 781 qlikisklny plenfikppi esdhvleyqd npavlnqfka qyntreqinr nfkyfilaqs 841 ririchivll isnlfkslvd fdccfhsidl kcgvpcynev lffcensrtw nenltrfniv 901 ldskfsliev sngesnyekc lmylsngnpy lyknakisfk tllsllisih ekinierdal 961 kdsyesdfha knvqwrmhsr plvatmlkhw ellyiknggi lalsdenlpi intnpsfrli 1021 iplyffaklr kcldiaptlr ciwnqdwnsm nsslekvcye reslreatey avsvitfwid 1081 tvsvmkgkst qtpiftitci fvsilviagy mrrledfaqn knsdcmigsl kstdrilwlk 1141 afktlkries hlsereyklq tfaeflrvpd ngsldiesld sslientlns hdvtnqaldi 1201 itrtrlssrt lycgarilgd tpvwpvsllf ahalqsraiy ninhrksvns v // LOCUS NP_013631 423 aa linear PLN 30-JUN-2025 DEFINITION tRNA dihydrouridine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013631 VERSION NP_013631.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182439.1 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09817. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..423 /product="tRNA dihydrouridine synthase" /EC_number="1.3.1.88" /calculated_mol_wt="48000" Region 32..358 /region_name="Dus" /note="Dihydrouridine synthase (Dus); pfam01207" /db_xref="CDD:426126" CDS 1..423 /gene="DUS1" /locus_tag="YML080W" /coded_by="NM_001182439.1:1..1272" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:12003496]" /experiment="EXISTENCE:direct assay:GO:0017150 tRNA dihydrouridine synthase activity [PMID:12003496]" /experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:14970222]" /experiment="EXISTENCE:mutant phenotype:GO:0017150 tRNA dihydrouridine synthase activity [PMID:14970222]" /note="Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNAs at U16 and U17 of the D loop" /db_xref="GeneID:854895" /db_xref="SGD:S000004545" ORIGIN 1 mtepalssan nalmqkltgr qlfdkigrpt rivapmvdqs elawrilsrr ygatlaytpm 61 lhaklfatsk kyrednwssl dgssvdrplv vqfcandpey llaaaklved kcdavdlnlg 121 cpqgiakkgh ygsflmeewd lihnlintlh knlkvpvtak irifddceks lnyakmvlda 181 gaqfltvhgr vreqkgqktg lanwetikyl rdnlpketvf fangnilype disrcmehig 241 adavmsaegn lynpgvfnvg qtknkekifp rvdkiireyf qivkecqesk asktamkshf 301 fkilrpflph htdirstlat mnakatweew eeqvvkpvek vvqeifeqpd iaikdeitig 361 ekqswggsyr tvpywrcqpy frpvngitgd krvmqglide svnkkrkadv plesadkkkd 421 vka // LOCUS NP_013632 201 aa linear PLN 30-JUN-2025 DEFINITION Cff1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013632 VERSION NP_013632.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182438.1 REFERENCE 1 (residues 1 to 201) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 201) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 201) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 201) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09818. Method: conceptual translation. FEATURES Location/Qualifiers source 1..201 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..201 /product="Cff1p" /calculated_mol_wt="22330" Region 31..178 /region_name="Cupin_5" /note="Cupin superfamily (DUF985); pfam06172" /db_xref="CDD:461843" CDS 1..201 /gene="CFF1" /locus_tag="YML079W" /coded_by="NM_001182438.1:1..606" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0072527 pyrimidine-containing compound metabolic process [PMID:36598488]" /note="Protein required for production of 4-hydroxy-5-methylfuran-3(2H)-one (MHF); cupin superfamily protein; has structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to nucleus and cytoplasm" /db_xref="GeneID:854896" /db_xref="SGD:S000004544" ORIGIN 1 msanvqeaan aaiepasfvk vpmpeppssl qqlindwqli khreggyfke tdrspytmev 61 ekpvnggsgn temvtrnqst liyylltpds pigkfhknin riihilqrgk gqyvlvypdg 121 qvksfkvgfd ykngevsqwv vpggvfkasf llpneefdng flisevvvpg fdfedhtflk 181 gedelkhlvg pekaaelafl a // LOCUS NP_013633 182 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase CPR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013633 VERSION NP_013633.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182437.1 REFERENCE 1 (residues 1 to 182) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 182) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 182) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 182) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09819. Method: conceptual translation. FEATURES Location/Qualifiers source 1..182 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..182 /product="peptidylprolyl isomerase CPR3" /EC_number="5.2.1.8" /calculated_mol_wt="19788" Region 23..180 /region_name="cyclophilin_ABH_like" /note="Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding...; cd01926" /db_xref="CDD:238907" Site order(72..73,78,129,131,139) /site_type="active" /db_xref="CDD:238907" CDS 1..182 /gene="CPR3" /locus_tag="YML078W" /gene_synonym="CYP3" /coded_by="NM_001182437.1:1..549" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:7603990]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:7603990]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:7603990]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17881727]" /note="Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria" /db_xref="GeneID:854897" /db_xref="SGD:S000004543" ORIGIN 1 mfkrsiiqqs rlfsnsasrl gkkvffdpav ngtkigrief elydnvvpkt aenfralctg 61 ekgwgykgvp fhriipdfmi qggdtdltng fggksiygsk fadenfvkkh dkagllsman 121 agpntngsqf fittvpcpwl dgkhvvfgev tkgmdivkai esygtasgkp raeivieeag 181 el // LOCUS NP_013634 159 aa linear PLN 30-JUN-2025 DEFINITION TRAPP subunit BET5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013634 VERSION NP_013634.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182436.1 REFERENCE 1 (residues 1 to 159) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 159) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 159) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 159) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09820. Method: conceptual translation. FEATURES Location/Qualifiers source 1..159 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..159 /product="TRAPP subunit BET5" /calculated_mol_wt="18303" Region 4..152 /region_name="TRAPPC1_MUM2" /note="Trafficking protein particle complex subunit 1; cd14855" /db_xref="CDD:341445" Site order(4,40,43..44,47,50..51,54..55,57..60,68..75,94) /site_type="other" /note="TRAPPC4 interface [polypeptide binding]" /db_xref="CDD:341445" Site order(11..13,45,52,80..81,83..84,86,104,107..108,112, 115..119) /site_type="other" /note="TRAPPC3 interface [polypeptide binding]" /db_xref="CDD:341445" Site order(42,46,50) /site_type="other" /note="GTPase interface [polypeptide binding]" /db_xref="CDD:341445" Site order(113..114,117..119,141..144) /site_type="other" /note="TRAPPC6 interface [polypeptide binding]" /db_xref="CDD:341445" CDS 1..159 /gene="BET5" /locus_tag="YML077W" /coded_by="NM_001182436.1:1..480" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17110339]" /experiment="EXISTENCE:direct assay:GO:1990070 TRAPPI protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990072 TRAPPIII protein complex [PMID:20375281]" /experiment="EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9611195]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9611195]" /experiment="EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17287728]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9611195|PMID:11239471]" /note="Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homology TRAPPC1 complements yeast null mutant" /db_xref="GeneID:854898" /db_xref="SGD:S000004542" ORIGIN 1 mgiysfwifd rhcncifdre wtlasnsasg tinskqneed akllygmifs lrsitqklsk 61 gsvkndirsi stgkyrvhty ctasglwfvl lsdfkqqsyt qvlqyiyshi yvkyvsnnll 121 spydfaenen emrgqgtrki tnrnfisvle sflapmvnq // LOCUS NP_013635 944 aa linear PLN 30-JUN-2025 DEFINITION War1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013635 VERSION NP_013635.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182435.1 REFERENCE 1 (residues 1 to 944) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 944) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 944) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 944) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09821. Method: conceptual translation. FEATURES Location/Qualifiers source 1..944 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..944 /product="War1p" /calculated_mol_wt="107430" Region 70..118 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(71,75,80..83,85,91,104) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(76,79,86,99,102,109) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..944 /gene="WAR1" /locus_tag="YML076C" /coded_by="NM_001182435.1:1..2835" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12588995]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:12588995]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12588995]" /experiment="EXISTENCE:direct assay:GO:0071468 cellular response to acidic pH [PMID:12588995]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:12588995]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12588995]" /experiment="EXISTENCE:mutant phenotype:GO:0071468 cellular response to acidic pH [PMID:12588995]" /note="Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively" /db_xref="GeneID:854899" /db_xref="SGD:S000004541" ORIGIN 1 mdtqiaitgv avgkeinndn sktdqkvslp kadvpcidka tqtiiegcsk ddprlsyptk 61 lettekgktk rnsfacvcch slkqkcepsd vndiyrkpcr rclkhkklck fdlskrtrkr 121 kprsrsptpf espmvnvstk skgptdsees slkdgtsyla sfpsdpnakq fpnsrtvlpg 181 lqqslsdlws tlsqppsyga reaettstge ittnnhtksn gsvptnpavl asndehtnis 241 dapviystyn spvpissapt sinsealfkh rpkivgdeet qnvkvkrqkk sysrhmtrsf 301 rkqlqsliis qkgkirdism kldtwskqwn dlveksmflp tiadpvsvgi isheeatlrl 361 hlykteisyl sklpfikvee nvsvdelrkk kpilfsvims cvsivltpkq ttrgtimkld 421 sfvlnlitnq ifkannksie iieslstlcl wynffewssk tryhifnyic ccltrdlgpt 481 yvnrsfgmfs dedpkrfksp lelysngasl tllvyisaln isiflrqsiq arwshvteka 541 cedlvketkk srhydndkll ldsaddpilv qfakmnhvle nihthlherd lnddefddpi 601 ftkkylnklm ekyhkqlqei ftkldrnrpr viafyysvea ylyqyklavf igemshtine 661 kvelpreimd dfvkcyhcck saleefskle pilitslplf htsriiytvg mlllklrysv 721 vaipsfhdlm pltddaialv igvnnllekt selypfnnsl ykfryvialf cqtyankvid 781 vadrynaere klkekqvide vsnghdgtkp inayvtesqk mpteedpiid nntnqnitav 841 pdemlpvysr vrddtaamnl ninstsymne sphehresmt gttllpppfi sndvtnsads 901 tnikpspsss vdnlndyltd inslawgvns lndefwtdlf mndi // LOCUS NP_013636 1054 aa linear PLN 30-JUN-2025 DEFINITION hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013636 VERSION NP_013636.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182434.1 REFERENCE 1 (residues 1 to 1054) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1054) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1054) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1054) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1054) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1054) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1054) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09822. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1054 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1054 /product="hydroxymethylglutaryl-CoA reductase (NADPH) HMG1" /EC_number="1.1.1.34" /calculated_mol_wt="115495" Region 10..161 /region_name="HPIH" /note="N-terminal domain with HPIH motif; pfam13323" /db_xref="CDD:404239" Region 189..1025 /region_name="2A060605" /note="3-hydroxy-3-methylglutaryl-coenzyme A reductase; TIGR00920" /db_xref="CDD:273339" Region 616..1025 /region_name="HMG_CoA_R_NADP" /note="3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP); TIGR00533" /db_xref="CDD:129624" Site order(663..664,666..667,672,677,680..695,707,712..719,735, 737,739,750,758,790,793,795..797,799,838,840..844,846, 848..853,855..857,864,866,868,887..888,890..899,905..908, 911..912,915,919..920,924..926,928..929,937,939,946,948, 950,962,967..968,970..971,973..974,1011) /site_type="other" /note="tetramerization interface [polypeptide binding]" /db_xref="CDD:153081" Site order(714,716..717,719..720,722..723,726,879,909,912, 1006..1007,1010,1016,1019..1020,1023) /site_type="other" /note="substrate binding pocket [chemical binding]" /db_xref="CDD:153081" Site order(714,848,924,1020) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:153081" Site order(714,717,720,892,908..909,912,1007,1011) /site_type="active" /note="inhibitor binding sites [active]" /db_xref="CDD:153081" Site order(745,781..783,806..814,816,847..848,924,959..961) /site_type="other" /note="NADP(H) binding site [chemical binding]" /db_xref="CDD:153081" CDS 1..1054 /gene="HMG1" /locus_tag="YML075C" /coded_by="NM_001182434.1:1..3165" /experiment="EXISTENCE:direct assay:GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity [PMID:3526336]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:8744950]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8744950]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:8744950]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:3526336]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762|PMID:22842922]" /experiment="EXISTENCE:genetic interaction:GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity [PMID:2828155]" /experiment="EXISTENCE:mutant phenotype:GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity [PMID:2828155]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:9292983]" /note="HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; expressed almost exclusively on the peri-nuclear side of the ER; human homolog HMGCR can complement yeast hmg1 mutant" /db_xref="GeneID:854900" /db_xref="SGD:S000004540" ORIGIN 1 mpplfkglkq makpiayvsr fsakrpihii lfsliisafa ylsviqyyfn gwqldsnsvf 61 etapnkdsnt lfqecshyyr dssldgwvsi taheaselpa phhyyllnln fnspnetdsi 121 pelantvfek dntkyilqed lsvskeisst dgtkwrlrsd rkslfdvktl ayslydvfse 181 nvtqadpfdv limvtaylmm fytifglfnd mrktgsnfwl sastvvnsas slflalyvtq 241 cilgkevsal tlfeglpfiv vvvgfkhkik iaqyalekfe rvglskritt deivfesvse 301 eggrliqdhl lcifafigcs myahqlktlt nfcilsafil ifeliltptf ysailalrle 361 mnvihrstii kqtleedgvv pstariiska ekksvssfln lsvvviimkl svillfvfin 421 fynfganwvn dafnslyfdk ervslpdfit snasenfkeq aivsvtplly ykpiksyqri 481 edmvllllrn vsvairdrfv sklvlsalvc savinvylln aarihtsyta dqlvktevtk 541 ksftapvqka stpvltnktv isgskvksls saqssssgps ssseeddsrd iesldkkirp 601 leeleallss gntkqlknke vaalvihgkl plyalekklg dttravavrr kalsilaeap 661 vlasdrlpyk nydydrvfga ccenvigymp lpvgvigplv idgtsyhipm attegclvas 721 amrgckaina gggattvltk dgmtrgpvvr fptlkrsgac kiwldseegq naikkafnst 781 srfarlqhiq tclagdllfm rfrtttgdam gmnmiskgve yslkqmveey gwedmevvsv 841 sgnyctdkkp aainwiegrg ksvvaeatip gdvvrkvlks dvsalvelni aknlvgsama 901 gsvggfnaha anlvtavfla lgqdpaqnve ssncitlmke vdgdlrisvs mpsievgtig 961 ggtvlepqga mldllgvrgp hatapgtnar qlarivacav lagelslcaa laaghlvqsh 1021 mthnrkpaep tkpnnldatd inrlkdgsvt ciks // LOCUS NP_013637 411 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase FPR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013637 VERSION NP_013637.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182433.1 REFERENCE 1 (residues 1 to 411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 411) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09823. Method: conceptual translation. FEATURES Location/Qualifiers source 1..411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..411 /product="peptidylprolyl isomerase FPR3" /EC_number="5.2.1.8" /calculated_mol_wt="46422" Region <118..162 /region_name="NPL" /note="Nucleoplasmin-like domain; pfam17800" /db_xref="CDD:465511" Region 320..407 /region_name="FKBP_C" /note="FKBP-type peptidyl-prolyl cis-trans isomerase; pfam00254" /db_xref="CDD:459735" CDS 1..411 /gene="FPR3" /locus_tag="YML074C" /gene_synonym="NPI46" /coded_by="NM_001182433.1:1..1236" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:7925954|PMID:8051210|PMID:7525596]" /experiment="EXISTENCE:direct assay:GO:0005527 macrolide binding [PMID:7925954]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26359986]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:7525596|PMID:8051210]" /experiment="EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:24297734]" /experiment="EXISTENCE:direct assay:GO:0051598 meiotic recombination checkpoint signaling [PMID:16179256]" /experiment="EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:16179256]" /note="Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication" /db_xref="GeneID:854901" /db_xref="SGD:S000004539" ORIGIN 1 msdllplaty slnvepytpv paidvtmpit vritmaalnp eaideenkps tlriikrnpd 61 fedddflggd fdedeidees seeeeeektq kkkkskgkka eseseddeed ddeddefqes 121 vlltlspeaq yqqsldltit peeevqfivt gsyaislsgn yvkhpfdtpm gvegededed 181 adiydsedyd ltpdedeiig ddmddlddee eeevrieevq eedeedndge eeqeeeeeee 241 qkeevkpepk kskkekkrkh eekeeekkak kvkkvefkkd leegptkpks kkeqdkhkpk 301 skvleggivi edrtigdgpq akrgarvgmr yigklkngkv fdkntsgkpf afklgrgevi 361 kgwdigvagm svggerriii papyaygkqa lpgipansel tfdvklvsmk n // LOCUS NP_013638 176 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL6 RPL6A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013638 VERSION NP_013638.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182432.1 REFERENCE 1 (residues 1 to 176) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 176) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 176) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 176) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09824. Method: conceptual translation. FEATURES Location/Qualifiers source 1..176 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..176 /product="60S ribosomal protein eL6 RPL6A" /calculated_mol_wt="19830" Region 26..176 /region_name="KOW_RPL6" /note="KOW motif of Ribosomal Protein L6; cd13156" /db_xref="CDD:240520" Site order(26,28,44..48,50,61..62,69..73,75,77..80,82..83,108, 131,134..135,157,160..162,166..167) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240520" CDS 1..176 /gene="RPL6A" /locus_tag="YML073C" /gene_synonym="YL16A" /coded_by="NM_001182432.1:1..531" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:3282992]" /note="Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication" /db_xref="GeneID:854902" /db_xref="SGD:S000004538" ORIGIN 1 msaqkapkwy psedvaalkk trkaarpqkl raslvpgtvl illagrfrgk rvvylkhled 61 ntllisgpfk vngvplrrvn aryviatstk vsvegvnvek fnveyfakek ltkkekkean 121 lfpeqqnkei kaervedqkv vdkaliaeik ktpllkqyls asfslkngdk phmlkf // LOCUS NP_013639 1545 aa linear PLN 30-JUN-2025 DEFINITION Tcb3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013639 VERSION NP_013639.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182431.1 REFERENCE 1 (residues 1 to 1545) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1545) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1545) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1545) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09825. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1545 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1545 /product="Tcb3p" /calculated_mol_wt="170945" Region 44..1335 /region_name="COG5038" /note="Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]" /db_xref="CDD:227371" CDS 1..1545 /gene="TCB3" /locus_tag="YML072C" /coded_by="NM_001182431.1:1..4638" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:33933446]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:15049706]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:23237950|PMID:22250200]" /experiment="EXISTENCE:direct assay:GO:0120010 intermembrane phospholipid transfer [PMID:33933446]" /experiment="EXISTENCE:genetic interaction:GO:0055091 phospholipid homeostasis [PMID:35440494]" /experiment="EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]" /experiment="EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:33205016]" /experiment="EXISTENCE:mutant phenotype:GO:0120010 intermembrane phospholipid transfer [PMID:33933446]" /note="Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane; regulates PI4P levels by controlling access of Sac1p to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; involved in intermembrane phospholipid transfer; also localizes to the mitochondria in a phosphorylated state and is enriched in bud membranes; mRNA is targeted to the bud tip" /db_xref="GeneID:854903" /db_xref="SGD:S000004537" ORIGIN 1 mtgikaqvhp ppdstlfhee ekkkvggnlp qkvinqqerg sdhapsghhq yhqlinhdan 61 dtktsnsvsd vskgqktads npegkkqssk difvassaqk tnqlpgpnpq gsigavpleg 121 lrpkefrsap srkpnkfdts itkpgvlddl gkldekdike kfhldsddkl fpwqnvgefh 181 asgkgspntk msrvikayil enfyndwycn iatvlgtcff swlfayigfs wwsmififlg 241 tatvynaeyt rfnrnirddl krvtveetls drvesttwln sflskfwviy mpvlsqqvkd 301 nvnpqlagva pgygidalai deftlgskap tikgiksytk tgkntvemdw sfaftpsdvs 361 dmtatearek inpkislgvt lgksfvsktm pilvedinva gkmrikvefg kafpnikivs 421 lqllepplid falkpiggdt lgldvmsflp glksfvknii nsnigpmlfp pnhldinved 481 imaaqskeai gvlavtiasa dslkgsdfit ntvdpyivmt tedavpgtde evrtsiksnv 541 knprwnetky lllntleqkl nlkcfdfndv rkdtvigdlq ldladllqnp vldnqtaelr 601 sgtkskgilh yslhwfpvke dkseekaver aeakakgkke denedtteke edeneessqt 661 dvgiakitlq kvkyldttss mtgslspcae lfidgqkvks yrtlrrinep swnetievlv 721 psksnskfvl kifddrmngk aliceysssl ddimttldta qefvkgspqg diyldvswks 781 iemtgafaaa nsvsepigci kldvkdaiik gdlsgvgdvd pyytvslnrr vlyksiyhsd 841 tdhpifdnst yvpifspnqi ltlefhdyqk igkdrfigsv qiptsnvfkk dpksgkyvgn 901 ngkeeisklk lkdhehkvte sivnvsttfi pinlvyspee lvnvekleke lkekkkkfea 961 tqeeneqeme knpkewevae iedpfdsdek kinrkaklsl nelikqksgi lsmqilegtl 1021 spssayleil addisypvfi cmkpsqgkln semanifird lnysklhfrv skkhiakdsd 1081 dvisetsyst lkllkqayee pmwlnfngsk mkvrflytpt svklpssesv edtgylnikl 1141 isghglksad rngysdpfvh ifvndkkvfk snikkktldp vwnedakipi lsrsknqvif 1201 nvldwdragd nddlgqasld vsslevgkty nwnlnlntqg siklqgsfnp eyikpsfdiv 1261 kggitdkpmk iasgaahatv giagtgigaa tgvatgglkk gghllkslgg npmkrskssn 1321 gnesngakks sekksfdrrs psnlnstsvt prasldydps vpntsyapvq saspvvkptd 1381 ntssssnkkd tpssnsrghs rassfartla phgtyngfit vvaaenvakh vqikisltqg 1441 grlkhiyktk sqkanndgva vfdeecsfka speanlvlga ishqrlsrdk dlgiaqinlg 1501 dpqiqqdgqi svklgdghli vkinygkdkn gqvppvpevp qeytq // LOCUS NP_013640 607 aa linear PLN 30-JUN-2025 DEFINITION Golgi transport complex subunit COG8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013640 VERSION NP_013640.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182430.1 REFERENCE 1 (residues 1 to 607) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 607) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 607) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 607) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09826. Method: conceptual translation. FEATURES Location/Qualifiers source 1..607 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..607 /product="Golgi transport complex subunit COG8" /calculated_mol_wt="69698" Region 28..360 /region_name="Dor1" /note="Dor1-like family; pfam04124" /db_xref="CDD:427729" Region <244..517 /region_name="PTZ00341" /note="Ring-infected erythrocyte surface antigen; Provisional" /db_xref="CDD:173534" CDS 1..607 /gene="COG8" /locus_tag="YML071C" /gene_synonym="DOR1" /coded_by="NM_001182430.1:1..1824" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /note="Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" /db_xref="GeneID:854904" /db_xref="SGD:S000004536" ORIGIN 1 melilnslis ddlteeqkrl sldflqdilq sntkdyesyf ssravpgsit ediaeidael 61 saldrkirkt lldntsqiig nilenddraq lddiaksleq lweldtnink aadrnvtndd 121 innesvsidd fleddkednd tgrimttesn nlarkkkede fhkalsrlrn ristkeddkd 181 dirsdtlvtv lenldsitdl melpflartc irtghyqeav mlythttslr srfpgstivd 241 evcekvlnei sttmlsglvk llstnvsvns lkkilqylns ippfdgktnk sllsvflamr 301 ykfitdeias ypldvessne sliemmvkrk ievlrehvym slnvflksfl ydtndleipf 361 peelestvlr ingtneekei eekeketkke eyqkqdsvan needvtenks iedvqeevqg 421 kvegeddgae rkteneiene tvnktedkae kekeeevntk dnkaekeeee inkvevtpee 481 psksidnkae keeeeinkve vtpeepskki rtskrenkip tnavmlqfvd kcityvlkdl 541 trglnsikls dsvclqlvyc sfrlcdlnrn yhhlflkkin dtslftteql araidkrael 601 askyiys // LOCUS NP_013641 584 aa linear PLN 30-JUN-2025 DEFINITION dihydroxyacetone kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013641 VERSION NP_013641.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182429.1 REFERENCE 1 (residues 1 to 584) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 584) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 584) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 584) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09827. Method: conceptual translation. FEATURES Location/Qualifiers source 1..584 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..584 /product="dihydroxyacetone kinase" /EC_number="2.7.1.28" /EC_number="2.7.1.29" /calculated_mol_wt="62076" Region 5..581 /region_name="dak_ATP" /note="dihydroxyacetone kinase, ATP-dependent; TIGR02361" /db_xref="CDD:274097" CDS 1..584 /gene="DAK1" /locus_tag="YML070W" /coded_by="NM_001182429.1:1..1755" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004371 glycerone kinase activity [PMID:12401799]" /experiment="EXISTENCE:genetic interaction:GO:0061610 glycerol to glycerone phosphate metabolic process [PMID:22979944]" /experiment="EXISTENCE:mutant phenotype:GO:0004371 glycerone kinase activity [PMID:12401799]" /note="Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation" /db_xref="GeneID:854932" /db_xref="SGD:S000004535" ORIGIN 1 msaksfevtd pvnsslkgfa lanpsitlvp eekilfrktd sdkialisgg gsghepthag 61 figkgmlsga vvgeifasps tkqilnairl vnenasgvll ivknytgdvl hfglsaerar 121 algincrvav igddvavgre kggmvgrral agtvlvhkiv gafaeeyssk ygldgtakva 181 kiindnlvti gssldhckvp grkfeselne kqmelgmgih nepgvkvldp ipstedlisk 241 ymlpklldpn dkdrafvkfd eddevvllvn nlggvsnfvi ssitskttdf lkenynitpv 301 qtiagtlmts fngngfsitl lnatkatkal qsdfeeiksv ldllnaftna pgwpiadfek 361 tsapsvnddl lhnevtakav gtydfdkfae wmksgaeqvi ksephiteld nqvgdgdcgy 421 tlvagvkgit enldklskds lsqavaqisd fiegsmggts gglysillsg fshgliqvck 481 skdepvtkei vakslgiald tlykytkark gsstmidale pfvkeftask dfnkavkaae 541 egakstatfe akfgrasyvg dssqvedpga vglceflkgv qsal // LOCUS NP_013642 552 aa linear PLN 30-JUN-2025 DEFINITION FACT complex subunit POB3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013642 VERSION NP_013642.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182428.1 REFERENCE 1 (residues 1 to 552) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 552) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 552) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 552) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09828. Method: conceptual translation. FEATURES Location/Qualifiers source 1..552 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..552 /product="FACT complex subunit POB3" /calculated_mol_wt="62863" Region 1..546 /region_name="POB3" /note="Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]; COG5165" /db_xref="CDD:227494" CDS 1..552 /gene="POB3" /locus_tag="YML069W" /coded_by="NM_001182428.1:1..1659" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10413469]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10413469]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:15082784|PMID:19683499]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:11432837]" /experiment="EXISTENCE:direct assay:GO:0035101 FACT complex [PMID:9705338]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:18089575]" /experiment="EXISTENCE:direct assay:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:15987999]" /experiment="EXISTENCE:genetic interaction:GO:0006261 DNA-templated DNA replication [PMID:10924459]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:10924459]" /experiment="EXISTENCE:physical interaction:GO:0006261 DNA-templated DNA replication [PMID:9199353]" /note="Subunit of the heterodimeric FACT complex (Spt16p-Pob3p); FACT associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854933" /db_xref="SGD:S000004534" ORIGIN 1 mstdfdriyl nqskfsgrfr iadsglgwki stsggsaanq arkpfllpat elstvqwsrg 61 crgydlkint knqgviqldg fsqddynlik ndfhrrfniq veqrehslrg wnwgktdlar 121 nemvfalngk ptfeipyari nntnltskne vgiefniqde eyqpagdelv emrfyipgvi 181 qtnvdenmtk keessnevvp kkedgaeged vqmaveeksm aeafyeelke kadigevagd 241 aivsfqdvff ttprgrydid iyknsirlrg ktyeyklqhr qiqrivslpk addihhllvl 301 aiepplrqgq ttypflvlqf qkdeetevql nlededyeen ykdklkkqyd akthivlshv 361 lkgltdrrvi vpgeykskyd qcavscsfka negylypldn afffltkptl yipfsdvsmv 421 nisragqtst ssrtfdlevv lrsnrgsttf aniskeeqql leqflksknl rvknedrevq 481 erlqtalgsd sdeedinmgs ageddesvde dfqvssdnda devaeefdsd aalsdaeggs 541 deerpskkpk ve // LOCUS NP_013643 464 aa linear PLN 30-JUN-2025 DEFINITION RBR-type E3 ubiquitin transferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013643 VERSION NP_013643.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182427.1 REFERENCE 1 (residues 1 to 464) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 464) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 464) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 464) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09829. Method: conceptual translation. FEATURES Location/Qualifiers source 1..464 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..464 /product="RBR-type E3 ubiquitin transferase" /EC_number="2.3.2.31" /calculated_mol_wt="53965" Region 3..145 /region_name="RWD_ScITT1-like" /note="RWD domain of Saccharomyces cerevisiae translation termination inhibitor protein ITT1 and related proteins; cd23783" /db_xref="CDD:467645" Region 174..236 /region_name="RING_Ubox" /note="RING finger (Really Interesting New Gene) domain and U-box domain superfamily; cl17238" /db_xref="CDD:473075" Site order(180,183,197,204,207,210,229,234) /site_type="other" /note="cross-brace motif" /db_xref="CDD:438496" Region 272..334 /region_name="IBR" /note="In Between Ring fingers; smart00647" /db_xref="CDD:214763" Region 397..454 /region_name="Rcat_RBR_RNF14" /note="Rcat domain found in RING finger protein 14 (RNF14); cd20354" /db_xref="CDD:439015" CDS 1..464 /gene="ITT1" /locus_tag="YML068W" /coded_by="NM_001182427.1:1..1395" /experiment="EXISTENCE:mutant phenotype:GO:0006449 regulation of translational termination [PMID:11570975]" /note="Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins" /db_xref="GeneID:854934" /db_xref="SGD:S000004533" ORIGIN 1 maltqfendl eilrdmypel emksvkveee gefpqringk llfkisllad vniefgeqhm 61 llsnlsnecv eftiyschyp dirrcvvmdi kslwistdek kmlidkalrl veetvdmsie 121 fadsftsili lifgfliddt aillfpngir kcltqdqydl fkqiseeatl qkvsrsnyhc 181 cicmemekgv rmiklpcena nvehylcrgc aksyftamiq enrissvrcp qceykelkle 241 dfksykkmlk alftplipvs flkevidtel ceryekmfyn qaatrlskyc pyacvtcrrc 301 dswctkedld damiqcqkch fvfcfdclha whgynnkcgk kvslstdiie eylddtvtsy 361 erkrkleaky grrvlelevn dylaekmldl aikkegsnlq rcpkckvvve rsegcnkmkc 421 evcgtlfcfi cgvllypedp yehfreaysg cygrlfegmp gtet // LOCUS NP_013644 352 aa linear PLN 30-JUN-2025 DEFINITION Erv41p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013644 VERSION NP_013644.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182426.1 REFERENCE 1 (residues 1 to 352) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 352) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 352) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 352) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09830. Method: conceptual translation. FEATURES Location/Qualifiers source 1..352 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..352 /product="Erv41p" /calculated_mol_wt="40575" Region 4..92 /region_name="ERGIC_N" /note="Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC); pfam13850" /db_xref="CDD:464000" Region <161..320 /region_name="COPIIcoated_ERV" /note="Endoplasmic reticulum vesicle transporter; pfam07970" /db_xref="CDD:462327" CDS 1..352 /gene="ERV41" /locus_tag="YML067C" /coded_by="NM_001182426.1:1..1059" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:11157978]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11157978]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11157978]" /note="Protein localized to COPII-coated vesicles; forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein" /db_xref="GeneID:854935" /db_xref="SGD:S000004532" ORIGIN 1 maglktfdaf pkteeqykkk stkggltsll tylfllfiaw tefgeyfggy idqqyvvdsq 61 vrdtvqinmd iyvntkcdwl qinvrdqtmd rklvleelql eempffipyd tkvndineii 121 tpeldeilge aipaefrekl dtrsffdesd pnkahlpefn gchvfgsipv nrvsgelqit 181 akslgyvasr kapleelkfn hvinefsfgd fypyidnpld ntaqfnqdep lttyvyytsv 241 vptlfkklga evdtnqysvn dyrylykdva akgdkmpgif fkynfeplsi vvsdvrlsfi 301 qflvrlvaic sflvycaswi ftlldmalit imgpkwslry qpddktkgil dr // LOCUS NP_013645 369 aa linear PLN 30-JUN-2025 DEFINITION Sma2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013645 VERSION NP_013645.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182425.1 REFERENCE 1 (residues 1 to 369) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 369) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 369) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 369) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09831. Method: conceptual translation. FEATURES Location/Qualifiers source 1..369 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..369 /product="Sma2p" /calculated_mol_wt="40741" CDS 1..369 /gene="SMA2" /locus_tag="YML066C" /coded_by="NM_001182425.1:1..1110" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18756268|PMID:24390141|PMID:17298976]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17298976]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0070583 spore membrane bending pathway [PMID:18756268]" /note="Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation" /db_xref="GeneID:854936" /db_xref="SGD:S000004531" ORIGIN 1 mlfpkrlivw gvllilslsq fvlylpattc tnskglrlca pqftitvigg sstanefias 61 vreflrlisy ltidmgwsne ftdpsvyede nlvdtfqpdk vfelnyfgfc krsnkskvyc 121 tsnenygmdv levlvrdvgi qlgnisttrs netkkfgdsl vltyrlalts irdflkhdkh 181 tgnalskali gspdpnvkgv sptknylkgv nlafilmmfn gmvfyfavle iivgflsicv 241 vsafggalsv gkrhrlfpml lkssssilvv iatltilcni vylialktle peevtdvgsd 301 naavhttgwe llkvnvgsgf imglaryaiq wvllvlafla anhykakpkk sdkytedtsn 361 spspdlmek // LOCUS NP_013646 914 aa linear PLN 30-JUN-2025 DEFINITION origin recognition complex subunit 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013646 VERSION NP_013646.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182424.1 REFERENCE 1 (residues 1 to 914) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 914) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 914) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 914) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09832. Method: conceptual translation. FEATURES Location/Qualifiers source 1..914 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..914 /product="origin recognition complex subunit 1" /calculated_mol_wt="104270" Region 5..189 /region_name="BAH_Orc1p_Yeast" /note="BAH, or Bromo Adjacent Homology domain, as present in Orc1p, which again is part of the Saccharomyces cerevisiae Sir1-origin recognition complex, and as present in Sir3p. The Orc1p BAH doman functions in epigenetic silencing. BAH domains are found in a...; cd04720" /db_xref="CDD:240071" Site order(61,64..65,93) /site_type="active" /note="Sir1p binding site [active]" /db_xref="CDD:240071" Region <448..715 /region_name="PTZ00112" /note="origin recognition complex 1 protein; Provisional" /db_xref="CDD:240274" Region 637..738 /region_name="AAA_lid_10" /note="AAA lid domain; pfam17872" /db_xref="CDD:407729" CDS 1..914 /gene="ORC1" /locus_tag="YML065W" /coded_by="NM_001182424.1:1..2745" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11168584]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:17825064]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11168584]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:9335335|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16581798|PMID:12897051]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:31263106]" /experiment="EXISTENCE:direct assay:GO:0043007 maintenance of rDNA [PMID:31263106]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16581798]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:9038340]" /experiment="EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:9335335]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:37020028|PMID:16716188]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:9038340]" /experiment="EXISTENCE:mutant phenotype:GO:0034728 nucleosome organization [PMID:37020028]" /note="Largest subunit of the origin recognition complex; involved in directing DNA replication by binding to replication origins; also involved in transcriptional silencing; exhibits ATPase activity; role in chromatin organization at replication origins, along with chromatin remodellers; ORC1 has a paralog, SIR3, that arose from the whole genome duplication" /db_xref="GeneID:854937" /db_xref="SGD:S000004530" ORIGIN 1 maktlkdlqg weiittdeqg niidggqkrl rrrgaktehy lkrssdgikl grgdsvvmhn 61 eaagtysvym iqelrlntln nvvelwalty lrwfevnpla hyrqfnpdan ilnrplnyyn 121 klfsetankn elyltaelae lqlfnfirva nvmdgskwev lkgnvdperd ftvryicept 181 gekfvdinie dvkayikkve preaqeylkd ltlpskkkei krgpqkkdka tqtaqisdae 241 tratditdne dgnedessdy espsdidvse dmdsgeisad eleeeedeee dedeeekear 301 htnsprkrgr kiklgkddid asvqpppkkr grkpkdpskp rqmllisscr anntpvirkf 361 tkknvarakk kytpfskrfk siaaipdlts lpefygnsse lmasrfenkl kttqkhqive 421 tifskvkkql nssyvkeeil ksanfqdylp arenefasiy lsaysaiesd sattiyvagt 481 pgvgktltvr evvkellsss aqreipdfly veinglkmvk ptdcyetlwn kvsgerltwa 541 asmeslefyf krvpknkkkt ivvlldelda mvtksqdimy nffnwttyen akliviavan 601 tmdlperqlg nkitsrigft rimftgythe elkniidlrl kglndsffyv dtktgnaili 661 daagndttvk qtlpedvrkv rlrmsadaie iasrkvasvs gdarralkvc kraaeiaekh 721 ymakhgygyd gktviedene eqiyddedkd liesnkakdd ndddddndgv qtvhithvmk 781 alnetlnshv itfmtrlsft aklfiyalln lmkkngsqeq elgdivdeik llievngsnk 841 fvmeiaktlf qqgsdniseq lriiswdfvl nqlldagilf kqtmkndric cvklnisvee 901 akramnedet lrnl // LOCUS NP_013647 245 aa linear PLN 30-JUN-2025 DEFINITION Ras family GTPase TEM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013647 VERSION NP_013647.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182423.1 REFERENCE 1 (residues 1 to 245) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 245) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 245) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 245) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09833. Method: conceptual translation. FEATURES Location/Qualifiers source 1..245 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..245 /product="Ras family GTPase TEM1" /calculated_mol_wt="27165" Region 21..202 /region_name="Spg1" /note="Septum-promoting GTPase (Spg1); cd04128" /db_xref="CDD:206701" Site 21..22 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206701" Site 27..34 /site_type="other" /note="G1 box" /db_xref="CDD:206701" Site order(29..35,45,51..52,78,132..133,135,167..169) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206701" Site order(35..46,50..51) /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206701" Site order(45,50..58) /site_type="other" /note="Switch I region" /db_xref="CDD:206701" Site order(50,54..61,68,70) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206701" Site 52 /site_type="other" /note="G2 box" /db_xref="CDD:206701" Site order(53,55..57,72,74,81..82,85,89,91..94) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206701" Site order(53..54,56,74..75,82,84,86..88) /site_type="other" /note="putative GDI interaction site [polypeptide binding]" /db_xref="CDD:206701" Site 53..57 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206701" Site 70..74 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206701" Site 75..78 /site_type="other" /note="G3 box" /db_xref="CDD:206701" Site order(78,80..90) /site_type="other" /note="Switch II region" /db_xref="CDD:206701" Site 81..86 /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206701" Site 89..93 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206701" Site 98..103 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206701" Site 121..129 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206701" Site 132..135 /site_type="other" /note="G4 box" /db_xref="CDD:206701" Site 167..169 /site_type="other" /note="G5 box" /db_xref="CDD:206701" Site 182..184 /site_type="other" /note="Rab subfamily motif 4 (RabSF4)" /db_xref="CDD:206701" CDS 1..245 /gene="TEM1" /locus_tag="YML064C" /coded_by="NM_001182423.1:1..738" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:12048186|PMID:25658911]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:19154724]" /experiment="EXISTENCE:direct assay:GO:0023056 positive regulation of signaling [PMID:32074005]" /experiment="EXISTENCE:mutant phenotype:GO:0031536 positive regulation of exit from mitosis [PMID:21321099]" /experiment="EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:25658911]" /experiment="EXISTENCE:mutant phenotype:GO:0040001 establishment of mitotic spindle localization [PMID:21937712]" /experiment="EXISTENCE:mutant phenotype:GO:1902542 regulation of protein localization to mitotic spindle pole body [PMID:25658911]" /experiment="EXISTENCE:mutant phenotype:GO:1904750 negative regulation of protein localization to nucleolus [PMID:10219244]" /note="GTPase involved in initiation of Mitotic Exit Network (MEN); GTP-binding protein of the Ras superfamily; accumulates at daughter spindle pole body and activates MEN kinase cascade; controls actomyosin and septin dynamics during cytokinesis" /db_xref="GeneID:854938" /db_xref="SGD:S000004529" ORIGIN 1 matpstgann sipavrnqve vqvglvgdaq vgktslmvky vqniydkeyt qtlgvnflkr 61 kvsirstdii fsimdlggqr efinmlpiat vgssviiflf dltrpetlss ikewyrqayg 121 lndsaipilv gtkydllidl dpeyqeqisr tsmkyaqvmn aplifcstak siniqkifki 181 alakifnltl tipeineigd plliykhlgg qqhrhhnksq drkshnirkp ssspsskaps 241 pgvnt // LOCUS NP_013648 255 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS1 RPS1B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013648 VERSION NP_013648.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182422.1 REFERENCE 1 (residues 1 to 255) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 255) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 255) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 255) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09834. Method: conceptual translation. FEATURES Location/Qualifiers source 1..255 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..255 /product="40S ribosomal protein eS1 RPS1B" /calculated_mol_wt="28681" Region 22..221 /region_name="Ribosomal_S3Ae" /note="Ribosomal S3Ae family; pfam01015" /db_xref="CDD:425987" CDS 1..255 /gene="RPS1B" /locus_tag="YML063W" /gene_synonym="PLC2; RP10B" /coded_by="NM_001182422.1:1..768" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Ribosomal protein of the small (40S) subunit; homologous to mammalian ribosomal protein S3A, no bacterial homolog; RPS1B has a paralog, RPS1A, that arose from the whole genome duplication" /db_xref="GeneID:854939" /db_xref="SGD:S000004528" ORIGIN 1 mavgknkrls rgkkglkkkv vdpftrkewf dikapstfen rnvgktlvnk stglknasda 61 lkgrvvevcl adlqgsedhs frkvklrvde vqgknlltnf hgmdfttdkl rsmvrkwqtl 121 ieanvtvkts ddyvlrifai aftrkqanqv krhsyaqssh irairkvise iltrevqnst 181 laqltsklip evinkeiena tkdifplqni hvrkvkllkq pkfdvgalma lhgegsgeek 241 gkkvsgfkde vletv // LOCUS NP_013649 392 aa linear PLN 30-JUN-2025 DEFINITION Mft1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013649 VERSION NP_013649.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182421.1 REFERENCE 1 (residues 1 to 392) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 392) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 392) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 392) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 392) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09835. Method: conceptual translation. FEATURES Location/Qualifiers source 1..392 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..392 /product="Mft1p" /calculated_mol_wt="44865" Region <57..159 /region_name="THOC7" /note="Tho complex subunit 7; pfam05615" /db_xref="CDD:461692" CDS 1..392 /gene="MFT1" /locus_tag="YML062C" /gene_synonym="MFT52" /coded_by="NM_001182421.1:1..1179" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:24084588]" /experiment="EXISTENCE:direct assay:GO:0003676 nucleic acid binding [PMID:12093753]" /experiment="EXISTENCE:mutant phenotype:GO:0000445 THO complex part of transcription export complex [PMID:11979277]" /experiment="EXISTENCE:mutant phenotype:GO:0000446 nucleoplasmic THO complex [PMID:11060033]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:11060033]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:12093753]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:11979277]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:16908536]" /note="Subunit of the THO complex; THO is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance" /db_xref="GeneID:854940" /db_xref="SGD:S000004527" ORIGIN 1 mplsqkqidq vrtkvhysev dtpfnkyldi lgkvtkltgs iingtlsndd skieklteqn 61 isqlkesahl rfldlqssid tkkvadenwe tcqqetlakl enlkdklpdi ksihsklllr 121 igklqglyds vqvinreveg lsegrtslvv traewekelg tdlvkfliek nylklvdpgl 181 kkdsseeryr iyddfskgpk elesinasmk sdienvrqev ssykekwlrd aeifgkitsi 241 fkeellkrdg llneaegdni dedyesdede erkerfkrqr smvevntien vdekeesdhe 301 yddqedeene eeddmevdve dikednevdg essqqednsr qgnneetdke tgvieepdav 361 ndaeeadsdh ssrklggtts dfsasssvee vk // LOCUS NP_013650 859 aa linear PLN 30-JUN-2025 DEFINITION DNA helicase PIF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013650 VERSION NP_013650.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182420.1 REFERENCE 1 (residues 1 to 859) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 859) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 859) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 859) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09836. Method: conceptual translation. FEATURES Location/Qualifiers source 1..859 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..859 /product="DNA helicase PIF1" /EC_number="3.6.4.12" /calculated_mol_wt="97551" Region 237..542 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Site order(241,259..266,341,381) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350795" Region <697..743 /region_name="SF1_C_RecD" /note="C-terminal helicase domain of RecD family helicases; cd18809" /db_xref="CDD:350196" Site 709 /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350196" CDS 1..859 /gene="PIF1" /locus_tag="YML061C" /gene_synonym="TST1" /coded_by="NM_001182420.1:1..2580" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:8253734]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:23596008]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:26411679]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:1849081|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006260 DNA replication [PMID:31744872]" /experiment="EXISTENCE:direct assay:GO:0010521 telomerase inhibitor activity [PMID:16121131]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:30442759]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:20655619]" /experiment="EXISTENCE:direct assay:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:16121131]" /experiment="EXISTENCE:direct assay:GO:0035861 site of double-strand break [PMID:33823531]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:30068549]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:26981397]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:23657261]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:genetic interaction:GO:0071932 replication fork reversal [PMID:26411679]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:15907372]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:10926538]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:24025772]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:1849081]" /experiment="EXISTENCE:mutant phenotype:GO:0010521 telomerase inhibitor activity [PMID:16121131]" /experiment="EXISTENCE:mutant phenotype:GO:0019985 translesion synthesis [PMID:30107417]" /experiment="EXISTENCE:mutant phenotype:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:16121131]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:8287473]" /note="DNA helicase, potent G-quadruplex DNA binder/unwinder; possesses strand annealing activity; promotes DNA synthesis during break-induced replication; involved in crossover recombination; works with Hrq1p to maintain telomere length homeostasis; translation from different start sites produces mitochondrial (DNA repair and recombination) and nuclear (catalytic inhibitor of telomerase) isoforms; mutations affect Zn, Fe homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells" /db_xref="GeneID:854941" /db_xref="SGD:S000004526" ORIGIN 1 mpkwirstln hiiprrpfic sfnsflllkn vshaklsfsm ssrgfrsnnf iqaqlkhpsi 61 lskedldlls dsddweepdc iqletekqek kiitdihked pvdkkpmrdk nvmnfinkds 121 plswndmfkp siiqppqlis ensfdqssqk ksrstgfknp lrpalkkess fdelqnnsis 181 qerslemine nekkkmqfge kiavltqrps ftelqndqdd snlnphngvk vkipiclske 241 qesiiklaen ghnifytgsa gtgksillre mikvlkgiyg renvavtast glaacniggi 301 tihsfagigl gkgdadklyk kvrrsrkhlr rwenigalvv deismldael ldkldfiark 361 irknhqpfgg iqlifcgdff qlppvskdpn rptkfafesk awkegvkmti mlqkvfrqrg 421 dvkfidmlnr mrlgniddet erefkklsrp lpddeiipae lystrmever annsrlsklp 481 gqvhifnaid ggaledeelk erllqnflap kelhlkvgaq vmmvknldat lvngslgkvi 541 efmdpetyfc yealtndpsm ppekletwae npsklkaame reqsdgeesa vasrkssvke 601 gfaksdigep vspldssvfd fmkrvktdde vvlenikrke qlmqtihqns agkrrlplvr 661 fkasdmstrm vlvepedwai edenekplvs rvqlplmlaw slsihksqgq tlpkvkvdlr 721 rvfekgqayv alsravsreg lqvlnfdrtr ikahqkvidf yltlssaesa ykqleadeqv 781 kkrkldyapg pkykaksksk snspapisat tqsnngiaam lqrhsrkrfq lkkesnsnqv 841 hslvsdeprg qdtedhile // LOCUS NP_013651 376 aa linear PLN 30-JUN-2025 DEFINITION 8-oxoguanine glycosylase OGG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013651 VERSION NP_013651.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182419.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09837. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..376 /product="8-oxoguanine glycosylase OGG1" /EC_number="4.2.99.18" /calculated_mol_wt="42650" Region 1..328 /region_name="ogg" /note="8-oxoguanine DNA-glycosylase (ogg); TIGR00588" /db_xref="CDD:211589" CDS 1..376 /gene="OGG1" /locus_tag="YML060W" /coded_by="NM_001182419.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11239005]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11239005]" /experiment="EXISTENCE:direct assay:GO:0006285 base-excision repair, AP site formation [PMID:8643552]" /experiment="EXISTENCE:direct assay:GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity [PMID:8643552]" /experiment="EXISTENCE:genetic interaction:GO:0070987 error-free translesion synthesis [PMID:19264809]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:11239005]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:19942858]" /note="Nuclear and mitochondrial glycosylase/lyase; specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance" /db_xref="GeneID:854942" /db_xref="SGD:S000004525" ORIGIN 1 msykfgklai nkselclanv lqagqsfrwi wdeklnqyst tmkigqqeky svvilrqdee 61 neilefvavg dcgnqdalkt hlmkyfrldv slkhlfdnvw ipsdkafakl spqgirilaq 121 epwetlisfi cssnnnisri trmcnslcsn fgnlittidg vayhsfptse eltsrateak 181 lrelgfgyra kyiietarkl vndkaeanit sdttylqsic kdaqyedvre hlmsyngvgp 241 kvadcvclmg lhmdgivpvd vhvsriakrd yqisanknhl kelrtkynal pisrkkinle 301 ldhirlmlfk kwgsyagwaq gvlfskeigg tsgstttgti kkrkwdmike teaivtkqmk 361 lkvelsdlhi keakid // LOCUS NP_013652 1679 aa linear PLN 30-JUN-2025 DEFINITION lysophospholipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013652 VERSION NP_013652.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182418.1 REFERENCE 1 (residues 1 to 1679) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1679) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1679) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1679) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1679) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09838. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1679 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1679 /product="lysophospholipase" /EC_number="3.1.1.5" /calculated_mol_wt="187003" Region 809..>944 /region_name="Crp" /note="cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; COG0664" /db_xref="CDD:440428" Region 957..1067 /region_name="CAP_ED" /note="effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; cd00038" /db_xref="CDD:237999" Site order(1023..1024,1033..1035) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:237999" Site order(1055..1057,1061..1063) /site_type="other" /note="flexible hinge region" /db_xref="CDD:237999" Region 1361..1629 /region_name="Pat_Fungal_NTE1" /note="Fungal patatin-like phospholipase domain containing protein 6; cd07227" /db_xref="CDD:132865" Site order(1378..1379,1381,1406,1524) /site_type="active" /db_xref="CDD:132865" Site 1404..1408 /site_type="other" /note="nucleophile elbow" /db_xref="CDD:132865" CDS 1..1679 /gene="NTE1" /locus_tag="YML059C" /coded_by="NM_001182418.1:1..5040" /experiment="EXISTENCE:direct assay:GO:0004622 phosphatidylcholine lysophospholipase activity [PMID:15044461]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:15044461|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0034638 phosphatidylcholine catabolic process [PMID:15044461]" /experiment="EXISTENCE:mutant phenotype:GO:0071071 regulation of phospholipid biosynthetic process [PMID:19841481]" /note="Serine esterase; homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes" /db_xref="GeneID:854943" /db_xref="SGD:S000004524" ORIGIN 1 mrsmncttnn tnntgqntkn slgssfnssn ytsyrfqtcl tdqiiseaqt wslsslfnfs 61 wvvsyfvmga srmifrygwy latlsllrip kwiffklhhv qftlsfwlil falavivfvt 121 ytimkerils qykrltpefl plentgksgs saninaastq sanappaigs sttgassiid 181 skkhslkdgn enetflssyl dqflsaikif gylekpvfhd ltknmktqkm degeilllds 241 tigfaivveg tlqlyhevdh sdkdhgdetd hsdtdglddq drdeedeeed ddidnydtks 301 cssnlideed esvgyihlkn glgnfqllnt vkpgnpltsl vsilnlfths mssygnsnfp 361 selsspidtt vsvnnmfcss eqnfsntdsm tnstnsfptf pssmpklvar aatdctigii 421 ppqsfaklta kyprsashii qmvltklyhv tfqtahdylg ltkeimdiev llnksivyel 481 pyylkeavir kfktvdkssg sadlepkpkn snassklkkp pkakpsdgii qslkianana 541 ntssnslslk pefthhpssr hvvlgsrdqf npgdllsnvp lsrtmdilsp npihnnnrnk 601 sngintstsn qhkrssrsss nnasvhskkf sslspelrna qlstsplsld ntsvhdhihp 661 spvhlkgrvs prpnllptts fsaaqeeted salrmalvea mltylgvnks nmsvssssia 721 nmsslnspql nemysrrpsn asflmsphct psdisvassf aspqtqptml rilpkeytis 781 nkrhnksksq dkkkprayke eltpnldfed vkkdfaqgiq lkffkkgtti veqnargkgl 841 fyiisgkvnv ttnssssvvs smskpeqvsa qsshkgenph htqhllysvg sggivgylss 901 ligyksfvni vaksdvyvgf lssatlerlf dkyfliylri sdsltkllss rllkldhale 961 wvhlrasetl fsqgdsangi yvvlngrlrq lqqqslsnsn tsseevetqn iilgelaqge 1021 sfgevevlta mnrystivav rdselaripr tlfellaleh psimirvsrl vakkivgdrt 1081 vpaltgdpls ikendftsli pptkasysss lshkpqnits gtitfrtiti lpitsglpve 1141 afamklvqaf kqvgrttigl nqrttlthlg rhafdrlskl kqsgyfaele emyqtvvyis 1201 dtpvksnwtr tciaqgdcil lladarspsa eigeyeklll nskttartel illhperyve 1261 pglthkwlry rpwvhshhhi qfsltgttlm negkmhvlnn galalmdkli qtefsrktqq 1321 niskllpdsi kntvenfssr fmkskrqyyt pvhrhkndfl rlarilsgqa iglvlgggga 1381 rgishlgviq aieeqgipvd viggtsigsf vgglyakdyd lvpiygrvkk fagrissiwr 1441 mltdltwpvt syttghefnr giwktfgdtr iedfwiqyyc nstnitdsvq eihsfgyawr 1501 yirasmslag llppleengs mlldggyvdn lpvtemrarg cqtifavdvg saddrtpmey 1561 gdslngfwii fnrwnpfssh pnipnmaeiq vrlgyvasvn alekakntpg vvyvrppiee 1621 yatldfskfe eiyhvgvdyg riflqglidd dkmpyipgsq ettlnsqvpe fllhrrnsi // LOCUS NP_219498 68 aa linear PLN 30-JUN-2025 DEFINITION Hug1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_219498 VERSION NP_219498.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184439.1 REFERENCE 1 (residues 1 to 68) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 68) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 68) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 68) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09839. Method: conceptual translation. FEATURES Location/Qualifiers source 1..68 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..68 /product="Hug1p" /calculated_mol_wt="7382" CDS 1..68 /gene="HUG1" /locus_tag="YML058W-A" /coded_by="NM_001184439.1:1..207" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:1990846 ribonucleoside-diphosphate reductase inhibitor activity [PMID:25378334]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:10490641]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:10490641]" /note="Ribonucleotide reductase inhibitor; intrinsically disordered protein that binds to and inhibits Rnr2p; involved in the Mec1p-mediated checkpoint pathway; transcription is induced by genotoxic stress and by activation of the Rad53p pathway; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854944" /db_xref="SGD:S000007472" ORIGIN 1 mtmdqglnpk qfflddvvlq dtlcsmsnrv nksvktgylf pkdhvpsani iaverrggls 61 digkntsn // LOCUS NP_013653 104 aa linear PLN 30-JUN-2025 DEFINITION ribonucleotide reductase inhibiting protein SML1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013653 VERSION NP_013653.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182417.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09840. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..104 /product="ribonucleotide reductase inhibiting protein SML1" /calculated_mol_wt="11703" CDS 1..104 /gene="SML1" /locus_tag="YML058W" /coded_by="NM_001182417.1:1..315" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:1990846 ribonucleoside-diphosphate reductase inhibitor activity [PMID:27155231|PMID:10593972]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:9774971]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:9774971]" /note="Ribonucleotide reductase inhibitor; involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase; SML1 has a paralog, DIF1, that arose from the whole genome duplication" /db_xref="GeneID:854945" /db_xref="SGD:S000004523" ORIGIN 1 mqnsqdyfya qnrcqqqqap stlrtvtmae frrvplppma evpmlstqns mgssasasas 61 slemwekdle erlnsidhdm nnnkfgsgel ksmfnqgkve emdf // LOCUS NP_013655 604 aa linear PLN 30-JUN-2025 DEFINITION calcineurin catalytic subunit A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013655 VERSION NP_013655.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182415.1 REFERENCE 1 (residues 1 to 604) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 604) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 604) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 604) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09841. Method: conceptual translation. FEATURES Location/Qualifiers source 1..604 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..604 /product="calcineurin catalytic subunit A" /EC_number="3.1.3.16" /calculated_mol_wt="68397" Region 95..423 /region_name="MPP_PP2B" /note="PP2B, metallophosphatase domain; cd07416" /db_xref="CDD:277361" Site order(107,109,144,146,172,204,213,253,359,392,419) /site_type="other" /note="CN-CyPA-CsA complex [polypeptide binding]" /db_xref="CDD:277361" Site order(144,146,172,176,204..205,253,286,332,359,361) /site_type="active" /db_xref="CDD:277361" Site order(144,146,172,204,253,359) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277361" CDS 1..604 /gene="CMP2" /locus_tag="YML057W" /gene_synonym="CNA2" /coded_by="NM_001182415.1:1..1815" /experiment="EXISTENCE:direct assay:GO:0004723 calcium-dependent protein serine/threonine phosphatase activity [PMID:1321337]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005955 calcineurin complex [PMID:1321337]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:1651503]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:8798496]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:1651503]" /note="Calcineurin A; one isoform (the other is Cna1p) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1; regulates the function of Aly1p alpha-arrestin; CMP2 has a paralog, CNA1, that arose from the whole genome duplication" /db_xref="GeneID:854946" /db_xref="SGD:S000004521" ORIGIN 1 mssdairnte qinaaikiie nkterpqsst tpidskastv aaanstatet srdltqytld 61 dgrvvstnrr imnkvpaits hvptdeelfq pngiprhefl rdhfkregkl saaqaarivt 121 latelfskep nlisvpapit vcgdihgqyf dllklfevgg dpattsylfl gdyvdrgsfs 181 fecliylysl klnfndhfwl lrgnheckhl tsyftfknem lhkynldiye kccesfnnlp 241 laalmngqyl cvhggispel nslqdinnln rfreipshgl mcdllwadpi eeydevldkd 301 lteedivnsk tmvphhgkma psrdmfvpns vrgcsyafty raachflqet gllsiirahe 361 aqdagyrmyk ntktlgfpsl ltlfsapnyl dtynnkaail kyennvmnir qfnmtphpyw 421 lpdfmdvftw slpfvgekvt emlvailnic tedelendtp vieelvgtdk klpqagksea 481 tpqpatsasp khasilddeh rrkalrnkil avakvsrmys vlreetnkvq flkdhnsgvl 541 prgalsngvk gldealstfe rarkhdline klppsldelk nenkkyyekv wqkvhehdak 601 ndsk // LOCUS NP_013656 524 aa linear PLN 30-JUN-2025 DEFINITION IMP dehydrogenase IMD4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013656 VERSION NP_013656.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182414.1 REFERENCE 1 (residues 1 to 524) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 524) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 524) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 524) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09842. Method: conceptual translation. FEATURES Location/Qualifiers source 1..524 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..524 /product="IMP dehydrogenase IMD4" /EC_number="1.1.1.205" /calculated_mol_wt="56263" Region 21..519 /region_name="PTZ00314" /note="inosine-5'-monophosphate dehydrogenase; Provisional" /db_xref="CDD:240355" CDS 1..524 /gene="IMD4" /locus_tag="YML056C" /coded_by="NM_001182414.1:1..1575" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:23222640]" /note="Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication" /db_xref="GeneID:854948" /db_xref="SGD:S000004520" ORIGIN 1 msaapldykk alehlktyss kdglsvqelm dsttrgglty ndflvlpglv nfpssavslq 61 tkltkkitln tpfvsspmdt vteadmaiym allggigfih hnctpkeqas mvkkvkmfen 121 gfinspivis ptttvgevkv mkrkfgfsgf pvtedgkcpg klvglvtsrd iqfleddslv 181 vsevmtknpv tgikgitlke gneilkqtkk gkllivddng nlvsmlsrad lmknqnypla 241 sksattkqll cgaaigtiea dkerlrllve agldvvilds sqgnsvfqln mikwiketfp 301 dleiiagnva treqaanlia agadglrigm gsgsicitqe vmacgrpqgt avynvcqfan 361 qfgvpcmadg gvqnighitk alalgsstvm mggmlagtte spgeyfykdg krlkayrgmg 421 sidamqktgn kgnastsryf sesdsvlvaq gvsgavvdkg sikkfipyly nglqhscqdi 481 gcesltslke nvqngevrfe frtasaqleg gvhnlhsyek rlyn // LOCUS NP_013657 178 aa linear PLN 30-JUN-2025 DEFINITION signal peptidase complex subunit SPC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013657 VERSION NP_013657.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182413.1 REFERENCE 1 (residues 1 to 178) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 178) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 178) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 178) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09843. Method: conceptual translation. FEATURES Location/Qualifiers source 1..178 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..178 /product="signal peptidase complex subunit SPC2" /calculated_mol_wt="20671" Region 20..170 /region_name="SPC25" /note="Microsomal signal peptidase 25 kDa subunit (SPC25); pfam06703" /db_xref="CDD:461993" CDS 1..178 /gene="SPC2" /locus_tag="YML055W" /gene_synonym="SPY1" /coded_by="NM_001182413.1:1..537" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005787 signal peptidase complex [PMID:8910564|PMID:1846444]" /experiment="EXISTENCE:genetic interaction:GO:0045047 protein targeting to ER [PMID:8910564]" /experiment="EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:10921929]" /experiment="EXISTENCE:mutant phenotype:GO:0008233 peptidase activity [PMID:10921929]" /experiment="EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:8910564]" /experiment="EXISTENCE:mutant phenotype:GO:0120236 negative regulation of post-translational protein targeting to membrane, translocation [PMID:32513868]" /experiment="EXISTENCE:physical interaction:GO:0045047 protein targeting to ER [PMID:8910564]" /note="Subunit of signal peptidase complex; complex catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; inhibits SRP-independent translocation into the ER with STE24; homologous to mammalian SPC25; other members of the complex are Spc1p, Spc1p, and Sec11p" /db_xref="GeneID:854949" /db_xref="SGD:S000004519" ORIGIN 1 mssakpinvy sipelnqald ealpsvfarl nyersyalld aklyigysia vvaglsffld 61 kkferdqivt yqkllvgayf vlsllfwyfs rfiekgtvyv gkrrgtkeei yvktkfekne 121 plylvelvqk kkgenskkel kaklevnkvf nesgylqnda yfkwfseqhn vldtkkne // LOCUS NP_013658 591 aa linear PLN 30-JUN-2025 DEFINITION L-lactate dehydrogenase (cytochrome) [Saccharomyces cerevisiae S288C]. ACCESSION NP_013658 VERSION NP_013658.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182412.1 REFERENCE 1 (residues 1 to 591) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 591) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 591) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 591) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09844. Method: conceptual translation. FEATURES Location/Qualifiers source 1..591 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..591 /product="L-lactate dehydrogenase (cytochrome)" /EC_number="1.1.2.3" /calculated_mol_wt="65409" Region 92..164 /region_name="Cyt-b5" /note="Cytochrome b5-like Heme/Steroid binding domain; pfam00173" /db_xref="CDD:459698" Region 206..555 /region_name="FCB2_FMN" /note="Flavocytochrome b2 (FCB2) FMN-binding domain. FCB2 (AKA L-lactate:cytochrome c oxidoreductase) is a respiratory enzyme located in the intermembrane space of fungal mitochondria which catalyzes the oxidation of L-lactate to pyruvate. FCB2 also...; cd02922" /db_xref="CDD:239238" Site order(206..207,210,214,229..230,361,365,370,410..411,430, 432..433,436,457..458,460,462) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:239238" Site order(223,275..276,278,308,332,360,429,453,456,489,493,513) /site_type="active" /db_xref="CDD:239238" Site order(223,334,362,369,453,456) /site_type="other" /note="substrate binding residues [chemical binding]" /db_xref="CDD:239238" Site order(275..276,308,332,360,429,489,493,513) /site_type="other" /note="FMN binding site [chemical binding]" /db_xref="CDD:239238" Site order(334,369,453) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239238" CDS 1..591 /gene="CYB2" /locus_tag="YML054C" /gene_synonym="FCB2" /coded_by="NM_001182412.1:1..1776" /experiment="EXISTENCE:direct assay:GO:0004460 L-lactate dehydrogenase (cytochrome) activity [PMID:3004948]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:11502169]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:3004948|PMID:6290489]" /experiment="EXISTENCE:mutant phenotype:GO:0006089 lactate metabolic process [PMID:8492799]" /note="Cytochrome b2 (L-lactate cytochrome-c oxidoreductase); component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions" /db_xref="GeneID:854950" /db_xref="SGD:S000004518" ORIGIN 1 mlkykpllki sknceaailr asktrlntir aygstvpksk sfeqdsrkrt qswtalrvga 61 ilaatssvay lnwhngqidn epkldmnkqk ispaevakhn kpddcwvvin gyvydltrfl 121 pnhpggqdvi kfnagkdvta ifeplhapnv idkyiapekk lgplqgsmpp elvcppyapg 181 etkediarke qlksllppld niinlydfey lasqtltkqa wayyssgand evthrenhna 241 yhriffkpki lvdvrkvdis tdmlgshvdv pfyvsatalc klgnplegek dvargcgqgv 301 tkvpqmistl ascspeeiie aapsdkqiqw yqlyvnsdrk itddlvknve klgvkalfvt 361 vdapslgqre kdmklkfsnt kagpkamkkt nveesqgasr alskfidpsl twkdieelkk 421 ktklpivikg vqrtedvika aeigvsgvvl snhggrqldf srapievlae tmpileqrnl 481 kdklevfvdg gvrrgtdvlk alclgakgvg lgrpflyans cygrngveka ieilrdeiem 541 smrllgvtsi aelkpdlldl stlkartvgv pndvlynevy egptltefed a // LOCUS NP_878139 52 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML054C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878139 VERSION NP_878139.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184571.1 REFERENCE 1 (residues 1 to 52) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 52) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 52) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 52) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 52) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09845. Method: conceptual translation. FEATURES Location/Qualifiers source 1..52 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..52 /product="uncharacterized protein" /calculated_mol_wt="5972" CDS 1..52 /locus_tag="YML054C-A" /coded_by="NM_001184571.1:1..159" /note="hypothetical protein" /db_xref="GeneID:1466497" /db_xref="SGD:S000028573" ORIGIN 1 mipfpaqhei fhayigritp hssrcianmw hsahffhens lsimktlvpw tl // LOCUS NP_013659 212 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML053C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013659 VERSION NP_013659.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182411.1 REFERENCE 1 (residues 1 to 212) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 212) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 212) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 212) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09846. Method: conceptual translation. FEATURES Location/Qualifiers source 1..212 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..212 /product="uncharacterized protein" /calculated_mol_wt="23812" CDS 1..212 /locus_tag="YML053C" /coded_by="NM_001182411.1:1..639" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene" /db_xref="GeneID:854952" /db_xref="SGD:S000004517" ORIGIN 1 mlsyyehnta fqtnncnsgs naattynsda nndtimnkrk ndhfefdtht fyqrskrtkr 61 dsvstkfsvg sgcanlnnnn nniiinnnnn nnnnnnnhnh nnsnntatyn nihykkniei 121 cplkpvsmhh tmnsrllnes efyseteeym ihgyfgntnr ditgtsptgs asiiqhqyhl 181 lpsqsiiasq apgtamaalt nnniandymd id // LOCUS NP_013660 302 aa linear PLN 30-JUN-2025 DEFINITION Sur7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013660 VERSION NP_013660.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182410.1 REFERENCE 1 (residues 1 to 302) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 302) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 302) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 302) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09847. Method: conceptual translation. FEATURES Location/Qualifiers source 1..302 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..302 /product="Sur7p" /calculated_mol_wt="33699" Region 18..206 /region_name="SUR7" /note="SUR7/PalI family; pfam06687" /db_xref="CDD:399580" CDS 1..302 /gene="SUR7" /locus_tag="YML052W" /coded_by="NM_001182410.1:1..909" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17507646|PMID:12469340]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:16496001|PMID:11784867]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:15536122]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:16496001]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11784867]" /experiment="EXISTENCE:mutant phenotype:GO:0097446 protein localization to eisosome filament [PMID:25811606]" /note="Plasma membrane protein, component of eisosomes; long-lived protein that remains stable in eisosomes of mother cells while other eisosome proteins, Pil1p and Lsp1p, turn over; may function to anchor the eisosome in place; sporulation and plasma membrane sphingolipid content are altered in mutants; localizes to furrow-like invaginations (MCC patches)" /db_xref="GeneID:854953" /db_xref="SGD:S000004516" ORIGIN 1 mvkvwnivlr lvvllflagn tlllilmiis gatdhypvnr fywvqgnttg ipnagdetrw 61 tfwgaclqdk dgsdtctsnl apaypispvd nfnthinvph qfiskrdafy yltrfsfcff 121 wialafvgvs filyvltwcs kmlsemvlil msfgfvfnta avvlqtaasa maknafhddh 181 rsaqlgasmm gmawasvflc ivefillvfw svrarlasty sidnsryrts srwnpfhrek 241 eqatdpilta tgpedmqqsa sivgpssnan pvtataaten qpkginffti rksherpddv 301 sv // LOCUS NP_013661 435 aa linear PLN 30-JUN-2025 DEFINITION transcription regulator GAL80 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013661 VERSION NP_013661.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182409.1 REFERENCE 1 (residues 1 to 435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 435) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09848. Method: conceptual translation. FEATURES Location/Qualifiers source 1..435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..435 /product="transcription regulator GAL80" /calculated_mol_wt="48192" Region 17..301 /region_name="MviM" /note="Predicted dehydrogenase [General function prediction only]; COG0673" /db_xref="CDD:440437" CDS 1..435 /gene="GAL80" /locus_tag="YML051W" /coded_by="NM_001182409.1:1..1308" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9811836]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10866670|PMID:18952899]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18952899|PMID:10866670]" /experiment="EXISTENCE:direct assay:GO:0019210 kinase inhibitor activity [PMID:18957435]" /experiment="EXISTENCE:direct assay:GO:0042326 negative regulation of phosphorylation [PMID:18957435]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:9811836]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:6092916]" /experiment="EXISTENCE:mutant phenotype:GO:0006012 galactose metabolic process [PMID:6092916]" /experiment="EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9811836]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:9811836]" /note="Transcriptional regulator involved in the repression of GAL genes; involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding" /db_xref="GeneID:854954" /db_xref="SGD:S000004515" ORIGIN 1 mdynkrssvs tvpnaapirv gfvglnaakg waikthypai lqlssqfqit alyspkiets 61 iatiqrlkls natafptles fassstidmi viaiqvashy evvmpllefs knnpnlkylf 121 vewalacsld qaesiykaaa ergvqtiisl qgrkspyilr akelisqgyi gdinsieiag 181 nggwygyerp vkspkyiyei gngvdlvttt fghtidilqy mtssyfsrin amvfnnipeq 241 elidergnrl gqrvpktvpd hllfqgtlln gnvpvscsfk ggkptkkftk nlvidihgtk 301 gdlklegdag faeisnlvly ysgtrandfp langqqapld pgydagkeim evyhlrnyna 361 ivgnihrlyq sisdfhfntk kipelpsqfv mqgfdfegfp tlmdalilhr liesvyksnm 421 mgstlnvsni shysl // LOCUS NP_013662 311 aa linear PLN 30-JUN-2025 DEFINITION Aim32p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013662 VERSION NP_013662.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182408.1 REFERENCE 1 (residues 1 to 311) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 311) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 311) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 311) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 311) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09849. Method: conceptual translation. FEATURES Location/Qualifiers source 1..311 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..311 /product="Aim32p" /calculated_mol_wt="35846" Region 60..306 /region_name="Suc_Fer-like" /note="Sucrase/ferredoxin-like; pfam06999" /db_xref="CDD:462062" CDS 1..311 /gene="AIM32" /locus_tag="YML050W" /coded_by="NM_001182408.1:1..936" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:34461091]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:30879301|PMID:34461091]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:34461091]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:34461091]" /note="2Fe-2S mitochondrial protein involved in redox quality control; may maintain protein redox status by targeting oxidation sensitive cysteine residues; bishistidinyl coordinated, non-Rieske [2Fe-2S] cluster containing thiredoxin-like ferredoxin; forms a functional complex with Osm1p and Erv1p in the IMS; required for assembly of numerous mitochondrial import complexes; essential for anaerobiosis; localizes to the mitochondrial matrix and intermembrane space (IMS); homologous to APD1" /db_xref="GeneID:854955" /db_xref="SGD:S000004514" ORIGIN 1 mlritvktlq qrasfhhsfk hisvpdlhtr aqndqtncyc qeinarlpsk tdpldphikl 61 phrtpnynkh vlllspgdrf aqpwkvawnh nldtntnrpy naisklrshl ggspgilina 121 vhlqnefipr pkqhdewlyf fvipdmklyv iketdieefa sfldegaiqa pklsfqdyls 181 gkakasqqvh evhhrkltrf qgetflrdwn lvcghykrda kcgemgpdii aafqdeklfp 241 ennlalishi gghifagnvi fyklfgrekm qnkldslwfg kvyphnlkll cenlengkii 301 demyrggism n // LOCUS NP_013663 1361 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit RSE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013663 VERSION NP_013663.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182407.1 REFERENCE 1 (residues 1 to 1361) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1361) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1361) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1361) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1361) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09850. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1361 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1361 /product="U2 snRNP complex subunit RSE1" /calculated_mol_wt="153654" Region 147..681 /region_name="MMS1_N" /note="Mono-functional DNA-alkylating methyl methanesulfonate N-term; pfam10433" /db_xref="CDD:463091" Region <1002..1328 /region_name="CPSF_A" /note="CPSF A subunit region; pfam03178" /db_xref="CDD:427182" CDS 1..1361 /gene="RSE1" /locus_tag="YML049C" /coded_by="NM_001182407.1:1..4086" /experiment="EXISTENCE:direct assay:GO:0000245 spliceosomal complex assembly [PMID:10369685]" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:15565172|PMID:16314500]" /experiment="EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:10369685]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9819400]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16314500]" /note="Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport" /db_xref="GeneID:854956" /db_xref="SGD:S000004513" ORIGIN 1 mwgggkmavv slsphtakmr klfgqasttm aydglkreae rrtrsdhnit mvakddelyl 61 yhltlkkqtn fvhscighfv dleagskreq sqlcvateth lelydtadge lkliakfqnl 121 fatitsmksl dlphsgsrak asnwptflal tsdsgnlsiv qiimhagalr lktlvnqplt 181 rttlrrvspi symeidpngr ciilssveqn klcflvdyaq klrissplei irphmvtldm 241 avvdvnfnnp cfvtleidna atqlsvhlif yvlelglnhi vkkadylvnp sanfvlslpd 301 lsrynittsl sdnnydadyd tlfnpfvvig fenhilvkdm ngffslkvei pkrsitnsrh 361 knvtiisgiv qklkndffvl lqsnhgdlfk ltvspdtndr nrplvqlsyf dtiqnshqlh 421 ifkngylfal semnnnflfq feklgveknd fsnvltskdp nkslvfepsi klqnlsilsq 481 qlnlnpsiks qivsdsplsi atkhftnnki itltnavnys nlistslppn atklwlipdp 541 attgdnntll fitfpkktmi lqidnesmee ltpdeatrsa fklsqdttih tclmgshsii 601 qvctaelrhi vptgksrysn kltwvppagi rivcatsskt qliislsnye lvyfkidvss 661 dslieltthp eldtmpskva ivqdtqhadl laiadnegmi kimslkdqke dfltvislql 721 vsekisdmim vrdssigqln lhvglengvy mkfhigdvdg sftdikrrfl glkpvslsyl 781 reisvslnne eeeeeeeddd dekeeeeins sgakwmscvv chssstwvsy twknvwtirq 841 lkdqnmlscs kfvnadvain gvcsisssgr lnigrvsnfp tldnwfhvhe ssvnkqengg 901 gdesneeeed emeeememlq istfrprtil sfpnnpksil fidnhsgkkq crislqidge 961 clkfgssdhl ykilddidcv saaiidftrq adhliicagd krlltykilv nkdklsfdie 1021 llhqteiisp ihamlkfknf lltamgstiv lyglgkkqll rrsvtqtpvs itkivsmhqw 1081 nyerlavgdi hesvtlfiwd pagnvfipyv ddsvkrhvtv lkfldeatvi gadrygnawt 1141 lrsppeceki msnhdpsels ngaikypldv itlqqklpnt ydckfkfqll nhffvndiit 1201 dfhildslsn sdrpgciymg lqgtvgcfip llskgnvfmm gnienimaea ddtfyldyes 1261 rkknnnmrke ddeeesgsvv lqgrhgiede iicegscsil grdhqeyrsy yapvrkvidg 1321 dlcenflrls lneqeflakn lksvqvedii qtinevrtny m // LOCUS NP_013664 403 aa linear PLN 30-JUN-2025 DEFINITION Gsf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013664 VERSION NP_013664.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182405.1 REFERENCE 1 (residues 1 to 403) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 403) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 403) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 403) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09851. Method: conceptual translation. FEATURES Location/Qualifiers source 1..403 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..403 /product="Gsf2p" /calculated_mol_wt="45739" Region 1..384 /region_name="Gsf2" /note="Glucose signalling factor 2; pfam11055" /db_xref="CDD:402576" CDS 1..403 /gene="GSF2" /locus_tag="YML048W" /gene_synonym="ECM6" /coded_by="NM_001182405.1:1..1212" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:10377429]" /experiment="EXISTENCE:genetic interaction:GO:0034394 protein localization to cell surface [PMID:10377429]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15623581]" /experiment="EXISTENCE:mutant phenotype:GO:0034394 protein localization to cell surface [PMID:10377429]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:15623581]" /note="Endoplasmic reticulum (ER) localized integral membrane protein; may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression" /db_xref="GeneID:854957" /db_xref="SGD:S000004511" ORIGIN 1 meiyirlnad vehdyafqvs nedtinnkik kifpsktgla dlmvlrpsif hekepvkfyk 61 sihpgylseg gclmfhyead neenleelnd skplidqlwp gqlvvpewkl skkniwvyti 121 imlawlytdl pdaisptpgi cltnqlsrll ipvakhmdlp eiaakleqev qanysslvaq 181 wlffvmhifk vgiitlflkl gianpisfnp yklwslrdlt spsangakns ggnnnttdlk 241 trlrslgwig akratyddyq tnyynyvidk mggavaayra gairkaaapg iqlvagegfq 301 spledrftas tftaikterk filseeyfve lennlkkile eydgdigkmn aeirrfrrfg 361 iyepdeklas lvklrreiad ekekasnnda tfgikkndlk ksn // LOCUS NP_013666 352 aa linear PLN 30-JUN-2025 DEFINITION pheromone-regulated K(+) transporter PRM6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013666 VERSION NP_013666.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182404.1 REFERENCE 1 (residues 1 to 352) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 352) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 352) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 352) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09852. Method: conceptual translation. FEATURES Location/Qualifiers source 1..352 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..352 /product="pheromone-regulated K(+) transporter PRM6" /calculated_mol_wt="41241" Region 9..231 /region_name="KCH" /note="Fungal potassium channel; pfam16944" /db_xref="CDD:435670" CDS 1..352 /gene="PRM6" /locus_tag="YML047C" /gene_synonym="KCH2" /coded_by="NM_001182404.1:1..1059" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23204190]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:23204190]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:23204190]" /experiment="EXISTENCE:genetic interaction:GO:0015079 potassium ion transmembrane transporter activity [PMID:23204190]" /experiment="EXISTENCE:genetic interaction:GO:0071805 potassium ion transmembrane transport [PMID:23204190]" /note="Potassium transporter that mediates K+ influx; activates high-affinity Ca2+ influx system (HACS) during mating pheromone response; expression up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; member of a fungal-specific gene family; PRM6 has a paralog, KCH1, that arose from the whole genome duplication" /db_xref="GeneID:854959" /db_xref="SGD:S000004510" ORIGIN 1 messlqklkf qdidinlipt akwttklqyi lytwcqsilh vamffsdiyt cikllafntw 61 snniiqpfle friskwlfsg cilcsslili welviglrvy rkkeitsnym ngisrlincl 121 fnfkkyqife livltdekkf skwlffsyfe isgclrllfg dsprqiingl tlwsvlltvs 181 netssgthst qslgnlddln giinkikhia ktnyeesvil sfmlfsfiiw vilisklils 241 iiifiifirp rflsskrkvk gyelklrkyv skvidenlsr tvyelgilid deeegticgd 301 nktqkkfdyd spdygdesti psyycysdve tyervytpik ayfpqkykhk yi // LOCUS NP_013667 629 aa linear PLN 30-JUN-2025 DEFINITION Prp39p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013667 VERSION NP_013667.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182403.1 REFERENCE 1 (residues 1 to 629) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 629) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 629) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 629) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09853. Method: conceptual translation. FEATURES Location/Qualifiers source 1..629 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..629 /product="Prp39p" /calculated_mol_wt="74617" Region 121..>217 /region_name="RNA14" /note="Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]; COG5107" /db_xref="CDD:227438" CDS 1..629 /gene="PRP39" /locus_tag="YML046W" /coded_by="NM_001182403.1:1..1890" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:8196608|PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:genetic interaction:GO:0000243 commitment complex [PMID:8196608]" /experiment="EXISTENCE:genetic interaction:GO:0000395 mRNA 5'-splice site recognition [PMID:8196608]" /experiment="EXISTENCE:genetic interaction:GO:0030627 pre-mRNA 5'-splice site binding [PMID:8196608]" /note="U1 snRNP protein involved in splicing; contains multiple tetriatricopeptide repeats" /db_xref="GeneID:854960" /db_xref="SGD:S000004509" ORIGIN 1 mpdetnftie dieprpdalr gldtqflqdn talvqayrgl dwsdissltq mvdvieqtvv 61 kygnpndsik laletilwqi lrkypllfgf wkrfatieyq lfglkksiav latsvkwfpt 121 slelwcdyln vlcvnnpnet dfirnnfeia kdligkqfls hpfwdkfief evgqknwhnv 181 qriyeyiiev plhqyarfft sykkflnekn lkttrnidiv lrktqttvne iwqfeskikq 241 pffnlgqvln ddlenwsryl kfvtdpsksl dkefvmsvfd rclipclyhe ntwmmyikwl 301 tkknisdevv vdiyqkantf lpldfktlry dflrflkrky rsnntlfnni fnetvsrylk 361 iwpndillmt eylcmlkrhs fknsldqspk eilekqtsft kiletsitny innqidakvh 421 lqtlindknl sivvvelikt twlvlknnmq trkyfnlyqk niliknsvpf wltyykfeks 481 nvnftklnkf irelgveiyl pttvmndilt dyktfylths nivtyessii dsntfdpily 541 pelkmsnpky dpvlnttanv dwhkktewke aghigitter pqisnsiiec nsgtliqkpi 601 slpnfrnlek inqvkindly teeflkegk // LOCUS NP_058176 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058176 VERSION NP_058176.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184412.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09855. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..440 /product="gag protein" /calculated_mol_wt="48991" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YML045W-A" /coded_by="NM_001184412.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:854962" /db_xref="SGD:S000007381" ORIGIN 1 mesqqlsnyp nishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenlhha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_013668 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013668 VERSION NP_013668.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182402.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09854. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198395" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YML045W" /coded_by="join(NM_001182402.2:1..1305, NM_001182402.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:854963" /db_xref="SGD:S000004508" ORIGIN 1 mesqqlsnyp nishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenlhha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsd dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmntwdtd kyydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlshlv qelnkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_013669 507 aa linear PLN 30-JUN-2025 DEFINITION Rrn11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013669 VERSION NP_013669.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182401.1 REFERENCE 1 (residues 1 to 507) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 507) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 507) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 507) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 507) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09856. Method: conceptual translation. FEATURES Location/Qualifiers source 1..507 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..507 /product="Rrn11p" /calculated_mol_wt="59123" Region 173..383 /region_name="RNA_pol_I_TF" /note="RNA polymerase I specific initiation factor; pfam04090" /db_xref="CDD:367807" CDS 1..507 /gene="RRN11" /locus_tag="YML043C" /coded_by="NM_001182401.1:1..1524" /experiment="EXISTENCE:direct assay:GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding [PMID:18451108]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:23613772]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:8702872]" /experiment="EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8887672]" /experiment="EXISTENCE:direct assay:GO:0070860 RNA polymerase I core factor complex [PMID:8887672|PMID:8702872]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8702872]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8702872]" /experiment="EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:8702872]" /note="Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p" /db_xref="GeneID:854964" /db_xref="SGD:S000004507" ORIGIN 1 mfevpitltn rkfaqrrklk yqyinyisrr fdriskkstt tdslptpens aaenndeeeg 61 qnseagtyrr svlqqkkrrr erhwrsvvge iysttesetd sqeeeteegg ehdtgidked 121 sdeerkfwkk yekpeksfei wrtvssqnkq pinkqkmtyh nfkkiekipl rkmeipllhc 181 tkenklyfqs isrgleplkt stsevrnyrt rhivtltdll hlnvsrhnws laykifatli 241 ripgvqiksl wgigveildn lsnsssgldf lqwmcqiyss ksrfvqniny rsivppfqtg 301 srthtakfai tylwsslinc qksmepssni idkpfdtend llqelidkis ewvltppfme 361 daevwfiyas chllkadtls rqfvndnknn dligldrdik inqvikhihy vrtflkicld 421 kggfavpsrl ienqlksfes rlygeaqdiq erdvanvyds idnssvensf gdvyetnaef 481 ldtqlmdlsp edngldemhy sdedsse // LOCUS NP_013670 670 aa linear PLN 30-JUN-2025 DEFINITION carnitine O-acetyltransferase CAT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013670 VERSION NP_013670.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182400.1 REFERENCE 1 (residues 1 to 670) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 670) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 670) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 670) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 670) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09857. Method: conceptual translation. FEATURES Location/Qualifiers source 1..670 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..670 /product="carnitine O-acetyltransferase CAT2" /EC_number="2.3.1.7" /calculated_mol_wt="77111" Region 77..651 /region_name="Carn_acyltransf" /note="Choline/Carnitine o-acyltransferase; pfam00755" /db_xref="CDD:459926" CDS 1..670 /gene="CAT2" /locus_tag="YML042W" /gene_synonym="YCAT" /coded_by="NM_001182400.1:1..2013" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:18427809|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:22375831|PMID:18427809]" /experiment="EXISTENCE:mutant phenotype:GO:0004092 carnitine O-acetyltransferase activity [PMID:8420957]" /experiment="EXISTENCE:mutant phenotype:GO:0009437 carnitine metabolic process [PMID:11329169]" /note="Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes" /db_xref="GeneID:854965" /db_xref="SGD:S000004506" ORIGIN 1 mrichsrtls nlkdlpitsr ramhsaivny stqkaqfpve tnngehywae kpnkfyqnkr 61 pnfqgitfak qqdlpslpvp elkstldkyl qtirpfcndv etferqqllc kdfsehmgpi 121 lqdrlkeyan dkrnwmakfw deqsylqynd pivpyvsyfy shmplpnhls kidndplika 181 taiistvvkf ieaikdeslp veiikgmpfc mnsfslmfnt srlpgkpedn qdtnifysvy 241 ennfvtiayk gkfyklmthd gndkplsene iwrqlysvvf qgsqsdpklg gigsltslpr 301 dqwrevhlel mkdpisqdsl etihkssfml cldldqspvt leeksrncwh gdginrfydk 361 slqflvtgng ssgflaehsk mdgtptlfln nyvcqqlnkl dvddfmrkvi tpsstvamkp 421 melpfiitpk ihkaiesaql qfketigehd lrvwhynkyg ktfikrhgms pdafiqqviq 481 lavfkylkrq lptyeaastr kyfkgrtetg rsvstaslef vskwqngdvp iaekiqalkh 541 sakehstylk naangngvdr hffglknmlk snddqipplf kdplfnysst wlistsqlss 601 eyfdgygwsq vndngfglay mlnnewlhin ivnkpaksga svnrlhyyls qaadeifdal 661 enenkrkakl // LOCUS NP_013671 280 aa linear PLN 30-JUN-2025 DEFINITION Vps71p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013671 VERSION NP_013671.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182399.1 REFERENCE 1 (residues 1 to 280) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 280) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 280) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 280) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09858. Method: conceptual translation. FEATURES Location/Qualifiers source 1..280 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..280 /product="Vps71p" /calculated_mol_wt="31890" Region 235..277 /region_name="zf-HIT_ZNHIT1_like" /note="HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; cd21437" /db_xref="CDD:467791" Site order(239..243,246..248,250,252..255,257,265..266) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467791" Site order(244,247,256,259,264,268,272,277) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:467791" CDS 1..280 /gene="VPS71" /locus_tag="YML041C" /gene_synonym="SWC6" /coded_by="NM_001182399.1:1..843" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14645854|PMID:14690608]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:14690608]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /experiment="EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:16299513]" /note="Nucleosome-binding component of the SWR1 complex; SWR1 exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting" /db_xref="GeneID:854966" /db_xref="SGD:S000004505" ORIGIN 1 mkalveeidk ktynpdiyft sldpqarryt skkinkqgti stsrpvkrin ysladlearl 61 ytsrsegdgn sisrqddrns knshsfeery tqqeilqsdr rfmelntenf sdlpnvptll 121 sdltgvprdr iesttkpisq tsdglsalmg gssfvkehsk yghgwvlkpe tlreiqlsyk 181 stklpkpkrk ntnrivalkk vlsskrnlhs fldsallnlm dknviyhnvy nkryfkvlpl 241 ittcsicggy dsisscvncg nkicsvscfk lhnetrcrnr // LOCUS NP_013673 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013673 VERSION NP_013673.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182398.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09860. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..440 /product="gag protein" /calculated_mol_wt="48862" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YML040W" /coded_by="NM_001182398.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:854968" /db_xref="SGD:S000004504" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_013672 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013672 VERSION NP_013672.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182397.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09859. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198442" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YML039W" /coded_by="join(NM_001182397.2:1..1305, NM_001182397.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:854969" /db_xref="SGD:S000004503" ORIGIN 1 mesqqlsqhs hishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdrs saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsd dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd eyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_013674 442 aa linear PLN 30-JUN-2025 DEFINITION Ymd8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013674 VERSION NP_013674.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182396.1 REFERENCE 1 (residues 1 to 442) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 442) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 442) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 442) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09861. Method: conceptual translation. FEATURES Location/Qualifiers source 1..442 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..442 /product="Ymd8p" /calculated_mol_wt="49484" Region 77..371 /region_name="TPT_S35C2" /note="solute carrier family 35 member C2, member of the triose-phosphate transporter family; cd21092" /db_xref="CDD:411044" CDS 1..442 /gene="YMD8" /locus_tag="YML038C" /coded_by="NM_001182396.1:1..1329" /experiment="EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0015786 UDP-glucose transmembrane transport [PMID:18693752]" /note="Putative nucleotide sugar transporter; has similarity to Vrg4p" /db_xref="GeneID:854970" /db_xref="SGD:S000004502" ORIGIN 1 mnrtvflafv fgwyfcsial siynrwmfdp kdglgigypv lvttfhqatl wllsgiyikl 61 rhkpvknvlr knngfnwsff lkfllptava sagdiglsnv sfqyvpltiy tiiksssiaf 121 vllfgcifkl ekfhwklals viimfvgval mvfkpsdsts tkndqalvif gsflvlassc 181 lsglrwvytq lmlrnnpiqt ntaaaveesd galftenedn vdnepvvnla nnkmlenfge 241 skphpihtih qlapimgitl lltsllvekp fpgifsssif rldtsnggvg tettvlsivr 301 givllilpgf avfllticef sileqtpvlt vsivgivkel ltvifgiiil serlsgfynw 361 lgmliimadv cyynyfrykq dllqkyhsvs tqdnrnelkg fqdfeqlgsk kiapysisvd 421 ltnqeyeldm iaqnvsrssq qv // LOCUS NP_013675 340 aa linear PLN 30-JUN-2025 DEFINITION Lft1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013675 VERSION NP_013675.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182395.1 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09862. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..340 /product="Lft1p" /calculated_mol_wt="37892" CDS 1..340 /gene="LFT1" /locus_tag="YML037C" /coded_by="NM_001182395.1:1..1023" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]" /note="hypothetical protein; binds HEATR5 protein Laa1p; has some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene" /db_xref="GeneID:854971" /db_xref="SGD:S000004501" ORIGIN 1 mdenkiidql fskeytpqdd seqakngdvs lyglldevan grrlmnclfh spmqmgnkls 61 tdkldgkcrq iqrdwideek titmnsgalq ldgpvlfsws hnvaptshqe tinttfkqgs 121 psrgsnkpki tttsqlfdra saeidkcikp nskswmveer ferneahtad gkkpstwans 181 dfkvdplqkf vvkelpkekk ksdgdktkkn kskrksffgf wghsgsksgs kkksekpiea 241 kneiqdevsq ksglspdddt tfsdkntiqs kqesmsdqqa epkvhepavt ntgcsehddg 301 dgfeqvpaqs syhpssepsi astpsltlds fiplqpkkki // LOCUS NP_013676 181 aa linear PLN 30-JUN-2025 DEFINITION Cgi121p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013676 VERSION NP_013676.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182394.1 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09863. On Jul 30, 2007 this sequence version replaced NP_013676.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..181 /product="Cgi121p" /calculated_mol_wt="20531" Region 19..180 /region_name="CGI-121" /note="Kinase binding protein CGI-121; pfam08617" /db_xref="CDD:462537" CDS 1..181 /gene="CGI121" /locus_tag="YML036W" /coded_by="NM_001182394.1:1..546" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:33277478]" /experiment="EXISTENCE:direct assay:GO:0000408 EKC/KEOPS complex [PMID:16564010|PMID:16874308]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:16564010]" /experiment="EXISTENCE:mutant phenotype:GO:0000049 tRNA binding [PMID:33277478]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:25822194]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:16564010]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:23390378]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16874308]" /note="Component of the EKC/KEOPS complex; EKC/KEOPS complex is required for t6A tRNA modification and telomeric TG1-3 recombination; may have role in transcription; Cgi121p is dispensable for tRNA modification; other complex members are Bud32p, Kae1p, Pcc1p, and Gon7p; ortholog of human TPRKB" /db_xref="GeneID:854972" /db_xref="SGD:S000004500" ORIGIN 1 mvvsiipqfp dikvslalfe qvknakeirs kmselstsfa fidprlvcsg eqmysaiykt 61 lievkynkmr trnlnsecvl clsptsnisd aflkfgikdd ssqliclkfh tntddvdkeq 121 lrtimtsivk gqeiefnddn lsrfydeali rkiyklsddf kpqdvnglsr alvdaiqlrg 181 v // LOCUS NP_013677 810 aa linear PLN 30-JUN-2025 DEFINITION AMP deaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013677 VERSION NP_013677.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182392.1 REFERENCE 1 (residues 1 to 810) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 810) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 810) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 810) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09864. Method: conceptual translation. FEATURES Location/Qualifiers source 1..810 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..810 /product="AMP deaminase" /EC_number="3.5.4.6" /calculated_mol_wt="93171" Region 160..803 /region_name="AMP_deaminase" /note="AMP deaminase; pfam19326" /db_xref="CDD:437158" CDS 1..810 /gene="AMD1" /locus_tag="YML035C" /gene_synonym="AMD3" /coded_by="NM_001182392.1:1..2433" /experiment="EXISTENCE:direct assay:GO:0003876 AMP deaminase activity [PMID:2690949]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006163 purine nucleotide metabolic process [PMID:19635936|PMID:18433446|PMID:15869715]" /experiment="EXISTENCE:genetic interaction:GO:0006178 guanine salvage [PMID:19635936]" /experiment="EXISTENCE:mutant phenotype:GO:0003876 AMP deaminase activity [PMID:2690949]" /experiment="EXISTENCE:mutant phenotype:GO:0006163 purine nucleotide metabolic process [PMID:19635936|PMID:20087341]" /experiment="EXISTENCE:mutant phenotype:GO:0006178 guanine salvage [PMID:19635936]" /note="AMP deaminase; tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; thought to be involved in regulation of intracellular purine (adenine, guanine, and inosine) nucleotide pools" /db_xref="GeneID:854973" /db_xref="SGD:S000004498" ORIGIN 1 mdnqatqrln dlslepapsh deqdgsglvi didqrkigde qagvvvddet ppleqqdshe 61 slaadsrnan fsyhenqqll engtkqlald ehdshsaile qpshstncss sniaamnkgh 121 dsadhasqns ggkprtlsas aqhilpetlk sfagapvvnk qvrtsasykm gmladdasqq 181 flddpsseli dlyskvaecr nlrakyqtis vqnddqnpkn kpgwvvyppp pkpsynsdtk 241 tvvpvtnkpd aevfdftkce ipgedpdwef tlndddsyvv hrsgktdeli aqiptlrdyy 301 ldlekmisis sdgpaksfay rrlqylearw nlyyllneyq etsvskrnph rdfynvrkvd 361 thvhhsacmn qkhllrfikh klrhskdekv ifrdgklltl devfrslhlt gydlsidtld 421 mhahkdtfhr fdkfnlkynp igesrlreif lktnnyikgt yladitkqvi fdlenskyqn 481 ceyrisvygr sldewdklas wvidnkvish nvrwlvqipr lydiykktgi vqsfqdickn 541 lfqplfevtk npqshpklhv flqrvigfds vddeskvdrr fhrkypkpsl weapqnppys 601 yylyylysnv aslnqwrakr gfntlvlrph cgeagdpehl vsayllahgi shgillrkvp 661 fvqylyyldq vgiamsplsn nalfltydkn pfpryfkrgl nvslstddpl qfsytrepli 721 eeysvaaqiy klsnvdmcel arnsvlqsgw eaqikkhwig kdfdksgveg ndvvrtnvpd 781 irinyrydtl stelelvnhf anfkrtieek // LOCUS NP_013679 834 aa linear PLN 30-JUN-2025 DEFINITION Src1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013679 VERSION NP_013679.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182391.1 REFERENCE 1 (residues 1 to 834) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 834) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 834) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 834) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 834) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 834) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 834) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09865. Method: conceptual translation. FEATURES Location/Qualifiers source 1..834 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..834 /product="Src1p" /calculated_mol_wt="95367" Region 14..48 /region_name="LEM_like" /note="LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; cd12935" /db_xref="CDD:240596" Region 464..820 /region_name="MSC" /note="Man1-Src1p-C-terminal domain; pfam09402" /db_xref="CDD:430586" CDS 1..834 /gene="SRC1" /locus_tag="YML034W" /gene_synonym="HEH1; YML033W" /coded_by="NM_001182391.1:1..2505" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:16929305]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000070 mitotic sister chromatid segregation [PMID:11754482]" /experiment="EXISTENCE:genetic interaction:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:11754482]" /experiment="EXISTENCE:mutant phenotype:GO:0043007 maintenance of rDNA [PMID:18997772]" /note="Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; enriched at telomeres and subtelomeric regions; associates with and regulates subtelomeric genes, interacting with TREX (transcription export) factors; produces two splice variants with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant is aneuploidy tolerant; SRC1 has a paralog, HEH2, that arose from the whole genome duplication" /db_xref="GeneID:854974" /db_xref="SGD:S000004497" ORIGIN 1 mnsdleyled gfdpnsmkva tlrrilvenn vdfpsnarkn alvglfdekv kpqipqlrkm 61 ylnvrpsdeg ivkmdrpsss psiasprrsr rarreksasp makqfkknri lddvsndddd 121 dddddddndk kddplivpsg tdtdevddee ddvitsssnk sdtndfqqns dtrkkrkdpd 181 sddwsesnsk enkidnkhln llssdseieq dyqkakkrkt sdlnqehgng sailgklsvk 241 tpikntnrkp vsmdnfndsl tssgtendpf vpnirhnpke lgtangtghs tplsklkvsa 301 sfadklpqke vpstilvpev eqqepsqser tpslfssegs gseseapllp eittpgphqp 361 mgntsnnvve midtdssnlv sdedevlvpt rietpqlpte kdvekcearv qelqeevneq 421 lehengsefd vkqgsgkvgn rhkfkralkf lsksllalfl fcifivipll fglwyreqrl 481 ligycghevp shrvsgnsfe fiqkldnllq dyrpkcipcp pngicypylk lkckpdykla 541 psrldfleii paqgkcvkdd kkqqlvsevv eksleflrak naqiscgdgk ddiesgmted 601 alyqifnear apwirddefe dlwiqvikdl teepeilwrq lsptdnnigg nsnniiktnd 661 vprqkrhlpe kfisktrnfr stskkyigmk crfereiyqt ykkfqrpiwl mflliviskv 721 ieiklknyyr kkarieelvt qtmeklkfqk iksmsdpken aylsivqlrd iflsdivdlk 781 yknqlwsevv kylehnnsni ksnlteirge imkcwewigp melnepkdsa enki // LOCUS NP_013680 471 aa linear PLN 30-JUN-2025 DEFINITION recombinase RAD52 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013680 VERSION NP_013680.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182390.1 REFERENCE 1 (residues 1 to 471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 471) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09866. On Jan 21, 2003 this sequence version replaced NP_013680.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..471 /product="recombinase RAD52" /calculated_mol_wt="52273" Region 20..180 /region_name="rad52" /note="recombination protein rad52; TIGR00607" /db_xref="CDD:129695" CDS 1..471 /gene="RAD52" /locus_tag="YML032C" /coded_by="NM_001182390.1:1..1416" /experiment="EXISTENCE:direct assay:GO:0000150 DNA strand exchange activity [PMID:15205482]" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:12766777]" /experiment="EXISTENCE:direct assay:GO:0000730 DNA recombinase assembly [PMID:11459983]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11459964|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:1990814 DNA/DNA annealing activity [PMID:27362509]" /experiment="EXISTENCE:genetic interaction:GO:0000709 meiotic joint molecule formation [PMID:18313389]" /experiment="EXISTENCE:genetic interaction:GO:0045002 double-strand break repair via single-strand annealing [PMID:11606529]" /experiment="EXISTENCE:mutant phenotype:GO:0000709 meiotic joint molecule formation [PMID:18313389]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:25822194|PMID:11238918]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:17096599|PMID:24190138]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:17096599]" /experiment="EXISTENCE:mutant phenotype:GO:0006277 DNA amplification [PMID:23271978]" /experiment="EXISTENCE:mutant phenotype:GO:0006301 postreplication repair [PMID:7038396]" /experiment="EXISTENCE:mutant phenotype:GO:0043504 mitochondrial DNA repair [PMID:26540255]" /note="Protein involved in homologous recombination; attenuates resection of DNA double-strand break ends and stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA (ssDNA); anneals complementary ssDNA; involved in the repair of double-strand breaks in DNA during vegetative growth, meiosis and UV induced sister chromatid recombination; forms a homodecameric ring; phosphorylation by Cdc28p in G2/M phase promotes Rad52p ring interaction that leads to superstructure formation" /db_xref="GeneID:854976" /db_xref="SGD:S000004494" ORIGIN 1 mneimdmdek kpvfgnhsed iqtkldkklg peyiskrvgf gtsriayieg wrvinlanqi 61 fgyngwstev ksvvidflde rqgkfsigct aivrvtltsg tyredigygt venerrkpaa 121 ferakksavt dalkrslrgf gnalgnclyd kdflakidkv kfdppdfden nlfrptdeis 181 essrtntlhe nqeqqqypnk rrqltkvtnt npdstknlvk ientvsrgtp mmaapaeans 241 knssnkdtdl ksldaskqdq ddllddslmf sddfqdddli nmgntnsnvl ttekdpvvak 301 qsptassnpe aeqitfvtak aatsvqnery igeesifdpk yqaqsirhtv dqttskhipa 361 svlkdktmtt ardsvyekfa pkgkqlsmkn ndkelgphml egagnqvpre ttpiktnata 421 fppaaaprfa ppskvvhpng ngavpavpqq rstrrevgrp kinplharkp t // LOCUS NP_013681 655 aa linear PLN 30-JUN-2025 DEFINITION Ndc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013681 VERSION NP_013681.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182389.1 REFERENCE 1 (residues 1 to 655) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 655) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 655) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 655) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09867. Method: conceptual translation. FEATURES Location/Qualifiers source 1..655 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..655 /product="Ndc1p" /calculated_mol_wt="74003" Region 21..640 /region_name="Ndc1_Nup" /note="Nucleoporin protein Ndc1-Nup; pfam09531" /db_xref="CDD:462824" CDS 1..655 /gene="NDC1" /locus_tag="YML031W" /coded_by="NM_001182389.1:1..1968" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:20498018]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:9864355]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:9864355]" /experiment="EXISTENCE:direct assay:GO:0070762 nuclear pore transmembrane ring [PMID:10684247|PMID:19414609]" /experiment="EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:16682526|PMID:15075274]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:16682526]" /experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:15075274|PMID:16682526]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:15075274|PMID:8349727]" /experiment="EXISTENCE:physical interaction:GO:0070762 nuclear pore transmembrane ring [PMID:19414609]" /note="Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1" /db_xref="GeneID:854977" /db_xref="SGD:S000004493" ORIGIN 1 miqtprelln prytyhtifs dvcktrfnhl vtrlfficsi iqtvvislla lphsplwela 61 lafipnilal nlvslliivt rknymhvknf gfansltfil gqllsvkflv yqgvysmgsi 121 llsfvlgvvf grggsgwkpy yklfiwlvvp tiynlqhhvt dadklsfnce nffqapqdyv 181 lervkrimek svilsvismf vlpifttvff srqksglfds ftngvlavtn lliisciifi 241 tfefiniafd ahmsigclhk gklisnlsst pmetllsgls adkpftrlta yqelayrats 301 ldpslrapiy hskfrsssgn twslilnecl ktiqinnekv vqylrsvqdl ggsatarhkk 361 kvenldymye ngkltsaner lfgnrpsmma plrdngllde spnrlrvrtd dsvllnrgnk 421 krhrssyydn dldettqtfn gsifthettf mtamrlmlkk lknsimsfif psyaerqssd 481 esdnyrllpn gsnkaqisii diwsiskkrq aeklvplpic hansvvaltg llirsktedp 541 kggiiasvgd ilktlersic algefadwdp esmaytafqt qrtaqdrvqq dsededsmkd 601 ttdmisvlyq lstsafmeiv leynvalndv yldadvakla nwflevyasg npnat // LOCUS NP_013682 159 aa linear PLN 30-JUN-2025 DEFINITION respiratory supercomplex assembly factor RCF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013682 VERSION NP_013682.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182388.1 REFERENCE 1 (residues 1 to 159) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 159) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 159) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 159) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 159) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09868. Method: conceptual translation. FEATURES Location/Qualifiers source 1..159 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..159 /product="respiratory supercomplex assembly factor RCF1" /calculated_mol_wt="18346" Region 30..81 /region_name="HIG_1_N" /note="Hypoxia induced protein conserved region; pfam04588" /db_xref="CDD:461361" CDS 1..159 /gene="RCF1" /locus_tag="YML030W" /gene_synonym="AIM31" /coded_by="NM_001182388.1:1..480" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14562095|PMID:14576278|PMID:24478450|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:22310663|PMID:22342701|PMID:22405070]" /experiment="EXISTENCE:direct assay:GO:0098803 respiratory chain complex [PMID:22405070|PMID:22310663|PMID:22342701]" /experiment="EXISTENCE:genetic interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:22310663]" /experiment="EXISTENCE:mutant phenotype:GO:0010155 regulation of proton transport [PMID:31591265]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:29746825]" /experiment="EXISTENCE:mutant phenotype:GO:0097250 mitochondrial respirasome assembly [PMID:22342701|PMID:22405070]" /note="Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast" /db_xref="GeneID:854978" /db_xref="SGD:S000004492" ORIGIN 1 msrmpssfdv terdlddmtf geriiyhckk qplvpigcll ttgavilaaq nvrlgnkwka 61 qyyfrwrvgl qaatlvalva gsfiygtsgk elkakeeqlk ekakmreklw iqelerreee 121 tearrkrael armktlenee eiknlekels dlenklgkk // LOCUS NP_013683 838 aa linear PLN 30-JUN-2025 DEFINITION Usa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013683 VERSION NP_013683.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182387.1 REFERENCE 1 (residues 1 to 838) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 838) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 838) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 838) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 838) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 838) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 838) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09869. Method: conceptual translation. FEATURES Location/Qualifiers source 1..838 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..838 /product="Usa1p" /calculated_mol_wt="96523" Region 276..341 /region_name="ubiquitin" /note="Ubiquitin family; pfam00240" /db_xref="CDD:459726" Region 741..789 /region_name="Usa1_DBD" /note="C-terminal Der1-binding domain of U1 SNP1-associating protein 1 (Usa1) and similar proteins; cd22577" /db_xref="CDD:439344" Site order(771,774..775,778,784) /site_type="other" /note="Der1 binding site [polypeptide binding]" /db_xref="CDD:439344" CDS 1..838 /gene="USA1" /locus_tag="YML029W" /coded_by="NM_001182387.1:1..2517" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:20005842]" /experiment="EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:31713515]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:16873066]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:16873066]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:11425851]" /experiment="EXISTENCE:physical interaction:GO:0005789 endoplasmic reticulum membrane [PMID:16873066]" /experiment="EXISTENCE:physical interaction:GO:0036503 ERAD pathway [PMID:16873066]" /note="Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p" /db_xref="GeneID:854979" /db_xref="SGD:S000004491" ORIGIN 1 mseylaqtpc kftiwsseid lirtnllvna hplstvgrll qyihyqiykq lraiyqpeeq 61 ctnseiphtp lnsintyfls yegrelsatc llkditsssh pdsnhfirlq lekrtspsgs 121 afdleydmeg efnsmniqfe intlssqrif nsmepnlpig ttlarlekla lerikdfeks 181 agnlcgiked hsvsdlqgfi ikgkqtpmfl nygsdsdyyk dlnlvdligi dfapahnsff 241 tflfkmnheq nshiandeer fvlefisdat lsitqmnvkp dttvkqvkdf icsvythsln 301 lrrndikliy kgqllhennf agnsskisey ikephevkvh vqinqeytes gpgfwnevfn 361 npnifqfmpp dtrsqspvsf aptqgrspaa irgeergipy vtesgndivp tdelyrkcii 421 ngdevvfipv selnpqssyl svikgdygei kipissndyr ingdnillsp saieqlesal 481 nfkierprds tllhpsgehv raadntssan dnntvendes awnrrvvrpl rnsfplllvl 541 irtfyligyn slvpffiile fgsflpwkyi illsllfifr tvwntqevwn lwrdylhlne 601 idevkfsqik efinsnsltl nfykkckdtq saidllmipn lheqrlsvys kydieydtnt 661 pdvgqlnllf ikvlsgeipk daldelfkef felyettrnm ntlypqdsln elllmiwkes 721 qkkdintlpk yrrwfqtlcs qiaehnvldv vlryiipdpv ndrvitavik nfvlfwvtll 781 pyvkeklddi vaqrardreq papsaqqqen edealiipde eeptatgaqp hlyipded // LOCUS NP_013684 196 aa linear PLN 30-JUN-2025 DEFINITION thioredoxin peroxidase TSA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013684 VERSION NP_013684.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182386.1 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09870. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..196 /product="thioredoxin peroxidase TSA1" /EC_number="1.11.1.24" /calculated_mol_wt="21459" Region 5..176 /region_name="PRX_Typ2cys" /note="Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; cd03015" /db_xref="CDD:239313" Site order(5,46..47,50,113,123,136..138,140..142,146..147,154, 169..172) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:239313" Site order(44,78..79,104,106,118) /site_type="other" /note="decamer (pentamer of dimers) interface [polypeptide binding]" /db_xref="CDD:239313" Site order(45,48,124) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:239313" Site order(48,169) /site_type="active" /note="peroxidatic and resolving cysteines [active]" /db_xref="CDD:239313" CDS 1..196 /gene="TSA1" /locus_tag="YML028W" /gene_synonym="TPX1; ZRG14" /coded_by="NM_001182386.1:1..591" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:8344960|PMID:10681558]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:18271751]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:15163410]" /experiment="EXISTENCE:direct assay:GO:0008379 thioredoxin peroxidase activity [PMID:9799566|PMID:7961686]" /experiment="EXISTENCE:direct assay:GO:0034599 cellular response to oxidative stress [PMID:15163410|PMID:8344960]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:15163410]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:18271751]" /experiment="EXISTENCE:direct assay:GO:0045454 cell redox homeostasis [PMID:8344960]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:15163410]" /experiment="EXISTENCE:direct assay:GO:0051920 peroxiredoxin activity [PMID:17210445]" /experiment="EXISTENCE:genetic interaction:GO:0000077 DNA damage checkpoint signaling [PMID:19851444]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:15051715]" /experiment="EXISTENCE:mutant phenotype:GO:0006111 regulation of gluconeogenesis [PMID:27634403]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:16251355|PMID:24022485]" /experiment="EXISTENCE:mutant phenotype:GO:0008379 thioredoxin peroxidase activity [PMID:7961686|PMID:9799566]" /experiment="EXISTENCE:mutant phenotype:GO:0019207 kinase regulator activity [PMID:27634403]" /experiment="EXISTENCE:mutant phenotype:GO:0033194 response to hydroperoxide [PMID:15210711]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:8344960|PMID:18271751]" /experiment="EXISTENCE:mutant phenotype:GO:0042262 DNA protection [PMID:19543365]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:9799566|PMID:8344960]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:16251355]" /experiment="EXISTENCE:mutant phenotype:GO:0072721 cellular response to dithiothreitol [PMID:16251355]" /note="Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form a HMW chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; hydrogen peroxide receptor and signal transducer in a light sensing pathway; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases and forms cytoplasmic foci during DNA replication stress" /db_xref="GeneID:854980" /db_xref="SGD:S000004490" ORIGIN 1 mvaqvqkqap tfkktavvdg vfdevsldky kgkyvvlafi plaftfvcpt eiiafseaak 61 kfeeqgaqvl fastdseysl lawtniprke gglgpinipl ladtnhslsr dygvlieeeg 121 valrglfiid pkgvirhiti ndlpvgrnvd ealrlveafq wtdkngtvlp cnwtpgaati 181 kptvedskey feaank // LOCUS NP_013685 385 aa linear PLN 30-JUN-2025 DEFINITION Yox1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013685 VERSION NP_013685.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182385.1 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09871. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..385 /product="Yox1p" /calculated_mol_wt="42608" Region 126..267 /region_name="COG5576" /note="Homeodomain-containing transcription factor [Transcription]" /db_xref="CDD:227863" CDS 1..385 /gene="YOX1" /locus_tag="YML027W" /coded_by="NM_001182385.1:1..1158" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:20385087|PMID:12464633]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:12464633]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12464633]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:17314407|PMID:12464633]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17314407|PMID:12464633]" /experiment="EXISTENCE:mutant phenotype:GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding [PMID:12464633]" /note="Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication" /db_xref="GeneID:854981" /db_xref="SGD:S000004489" ORIGIN 1 msqetkmlps lssllsgtei ssspvspsft nprtsfhldd rgtiklppln tsinrprsve 61 salrhtvtsl henssaygdd mlkhtqsdsa lssqlnssqe tvdeshenll ltplnskkrd 121 ysvsskkndi ltplsaaksi iipsaskekr rafafithsq etfpkkepki dnaplarrkr 181 rrtssqelsi lqaefekcpa pskekriela eschmtekav qiwfqnkrqa vkrqriatsk 241 sttiiqtvsp psppldvhat plasrvkadi lrdgsscsrs ssssplentp prphhslnrr 301 sstpsikrsq altfhlnpqk ktltpvktsp nsrvnklins idhspskakr pvsnpsgspk 361 rkrkfgfkiv dqqplkdldp nafrg // LOCUS NP_013686 146 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS13 RPS18B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013686 VERSION NP_013686.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182384.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09872. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..146 /product="40S ribosomal protein uS13 RPS18B" /calculated_mol_wt="16906" Region 1..144 /region_name="PTZ00134" /note="40S ribosomal protein S18; Provisional" /db_xref="CDD:185469" CDS 1..146 /gene="RPS18B" /locus_tag="YML026C" /coded_by="NM_001182384.1:1..441" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:14627813]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S18 and bacterial S13; RPS18B has a paralog, RPS18A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854982" /db_xref="SGD:S000004488" ORIGIN 1 mslvvqeqgs fqhilrllnt nvdgnikivy alttikgvgr rysnlvckka dvdlhkrage 61 ltqeeleriv qimqnpthyk ipawflnrqn ditdgkdyht lannvesklr ddlerlkkir 121 ahrgirhfwg lrvrgqhtkt tgrrra // LOCUS NP_013687 286 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL4m YML6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013687 VERSION NP_013687.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182383.1 REFERENCE 1 (residues 1 to 286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 286) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09873. Method: conceptual translation. FEATURES Location/Qualifiers source 1..286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..286 /product="mitochondrial 54S ribosomal protein uL4m YML6" /calculated_mol_wt="31839" Region 58..272 /region_name="Ribosomal_L4" /note="Ribosomal protein L4/L1 family; pfam00573" /db_xref="CDD:425758" CDS 1..286 /gene="YML6" /locus_tag="YML025C" /gene_synonym="uL4m" /coded_by="NM_001182383.1:1..861" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit; has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins" /db_xref="GeneID:854983" /db_xref="SGD:S000004487" ORIGIN 1 mtikrnlvkt lqsiryqatt atahaestln plpnaaippk yalvtvrsfp slepltfvpv 61 ptstvaaplr rdilwravvy endnrrvgas nppgrsengf srrklmpqkg sgrarvgdan 121 sptrhnggra lartapndyt telpskvysm afnnalshqy ksgklfvigg ekvdlisptp 181 eldlnrldlv ntntvegkei fegevifrkf leefqlkgkr llfitdktre glikssdpyk 241 qkvdviqkel vevndilraq avfieleale ylamahqkei lhsvsn // LOCUS NP_013688 136 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS17 RPS17A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013688 VERSION NP_013688.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182382.1 REFERENCE 1 (residues 1 to 136) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 136) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 136) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 136) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09874. Method: conceptual translation. FEATURES Location/Qualifiers source 1..136 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..136 /product="40S ribosomal protein eS17 RPS17A" /calculated_mol_wt="15657" Region 1..115 /region_name="Ribosomal_S17e" /note="Ribosomal S17; pfam00833" /db_xref="CDD:425895" CDS 1..136 /gene="RPS17A" /locus_tag="YML024W" /gene_synonym="RP51A; RPL51A" /coded_by="NM_001182382.1:1..411" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:3915776]" /note="Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication" /db_xref="GeneID:854984" /db_xref="SGD:S000004486" ORIGIN 1 mgrvrtktvk raskaliery ypkltldfqt nkrlcdeiat iqskrlrnki agytthlmkr 61 iqkgpvrgis fklqeeerer kdqyvpevsa ldlsrsngvl nvdnqtsdlv kslglklpls 121 vinvsaqrdr ryrkrv // LOCUS NP_013689 556 aa linear PLN 30-JUN-2025 DEFINITION Smc5-Smc6 complex subunit NSE5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013689 VERSION NP_013689.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182381.1 REFERENCE 1 (residues 1 to 556) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 556) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 556) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 556) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09875. Method: conceptual translation. FEATURES Location/Qualifiers source 1..556 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..556 /product="Smc5-Smc6 complex subunit NSE5" /calculated_mol_wt="63882" Region 1..517 /region_name="Nse5" /note="DNA repair proteins Nse5 and Nse6; pfam08691" /db_xref="CDD:462563" CDS 1..556 /gene="NSE5" /locus_tag="YML023C" /coded_by="NM_001182381.1:1..1671" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:34191293]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391]" /note="Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair" /db_xref="GeneID:854985" /db_xref="SGD:S000004485" ORIGIN 1 mdgalinsvl yvsprngahy fveltekhll afemlnsmcl lenydhvllf lecqfgkshn 61 lavipfdiil vlftlstlse yykepilran dpyntsretl srralkllqk ylailkefds 121 eqynlydlel lrcqfflaid tltpkkqkwg fdrfrrtkse sgvtyrqnas vdpeldqakt 181 fknpyrsyis cleqrntilg nrllnlklne pgefinmilw tlsnslqest plflssheiw 241 mplleilidl fscrqdyfiq hevaqnvsks lfvqrlsesp lavffeslnt rnfanrfsey 301 vflncdyklp sdnyatpvhp vyngentivd tyiptikcsp lyksqkslal rrkligscfk 361 lllrvpdghr litprivadd viqgisrtla sfndilqfkk ffmtenlsqe syfipllaeg 421 tlseilkdtq ecvviltlve nlsdgvsfcn eviglvkskc fafteqcsqa syeeavlnie 481 kcdvcllvll ryllhligte aildakeqle mlhaieknds grrqwakaln lgndppllyp 541 ivsqmfgvhd ksviie // LOCUS NP_013690 187 aa linear PLN 30-JUN-2025 DEFINITION adenine phosphoribosyltransferase APT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013690 VERSION NP_013690.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182380.1 REFERENCE 1 (residues 1 to 187) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 187) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 187) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 187) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09876. Method: conceptual translation. FEATURES Location/Qualifiers source 1..187 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..187 /product="adenine phosphoribosyltransferase APT1" /EC_number="2.4.2.7" /calculated_mol_wt="20456" Region 10..180 /region_name="apt" /note="adenine phosphoribosyltransferase; TIGR01090" /db_xref="CDD:273437" CDS 1..187 /gene="APT1" /locus_tag="YML022W" /coded_by="NM_001182380.1:1..564" /experiment="EXISTENCE:direct assay:GO:0003999 adenine phosphoribosyltransferase activity [PMID:9864350]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006168 adenine salvage [PMID:9864350]" /note="Adenine phosphoribosyltransferase; catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis; APT1 has a paralog, APT2, that arose from the whole genome duplication" /db_xref="GeneID:854986" /db_xref="SGD:S000004484" ORIGIN 1 msiasyaqel klalhqypnf psegilfedf lpifrnpglf qklidafklh leeafpevki 61 dyivglesrg flfgptlala lgvgfvpvrk agklpgecfk atyekeygsd lfeiqknaip 121 agsnviivdd iiatggsaaa agelveqlea nlleynfvme ldflkgrskl napvftllna 181 qkealkk // LOCUS NP_013691 359 aa linear PLN 30-JUN-2025 DEFINITION uracil-DNA glycosylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013691 VERSION NP_013691.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182379.1 REFERENCE 1 (residues 1 to 359) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 359) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 359) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 359) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 359) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09877. Method: conceptual translation. FEATURES Location/Qualifiers source 1..359 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..359 /product="uracil-DNA glycosylase" /EC_number="3.2.2.27" /calculated_mol_wt="40340" Region 103..328 /region_name="ung" /note="uracil-DNA glycosylase; TIGR00628" /db_xref="CDD:273182" Site order(160..163,165,174..175,186,222,300) /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:381678" Region 160..164 /region_name="motif A" /note="motif A [structural motif]" /db_xref="CDD:381678" Site order(161..162,164..165,184..186,268..269,299..300, 302..305) /site_type="active" /db_xref="CDD:381678" Site order(161,164..165,169,183..186,231..234,268..270,273,300, 302..305) /site_type="other" /note="UGI interface [polypeptide binding]" /db_xref="CDD:381678" Site order(162,300) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:381678" CDS 1..359 /gene="UNG1" /locus_tag="YML021C" /coded_by="NM_001182379.1:1..1080" /experiment="EXISTENCE:direct assay:GO:0004844 uracil DNA N-glycosylase activity [PMID:2644266]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11812822|PMID:24034606]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24034606|PMID:11812822]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:1938887]" /note="Uracil-DNA glycosylase; required for repair of uracil in DNA formed by spontaneous cytosine deamination; efficiently excises uracil from single-stranded DNA in vivo; not required for strand-specific mismatch repair; cell-cycle regulated, expressed in late G1; localizes to mitochondria and nucleus" /db_xref="GeneID:854987" /db_xref="SGD:S000004483" ORIGIN 1 mwcmrrlptn svmtvarkrk qttiedffgt kkstneapnk kgksgatfmt itngaaikte 61 tkavakeant dkypansnak dvysknlssn lrtllslele tiddswfphl mdefkkpyfv 121 klkqfvtkeq adhtvfppak diyswtrltp fnkvkvviig qdpyhnfnqa hglafsvkpp 181 tpappslkni ykelkqeypd fvednkvgdl thwasqgvll lntsltvrah nanshskhgw 241 etftkrvvql liqdreadgk slvfllwgnn aiklvesllg stsvgsgsky pnimvmksvh 301 psplsasrgf fgtnhfkmin dwlyntrgek midwsvvpgt slrevqeana rleseskdp // LOCUS NP_013692 664 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML020W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013692 VERSION NP_013692.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182378.1 REFERENCE 1 (residues 1 to 664) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 664) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 664) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 664) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09878. Method: conceptual translation. FEATURES Location/Qualifiers source 1..664 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..664 /product="uncharacterized protein" /calculated_mol_wt="76007" CDS 1..664 /locus_tag="YML020W" /coded_by="NM_001182378.1:1..1995" /note="hypothetical protein" /db_xref="GeneID:854988" /db_xref="SGD:S000004482" ORIGIN 1 mvttplhssp ksslksstts lrsvhtqsgr mgpsepkhrt tkswsiwggn deeepelsnk 61 nkgketaqdn sqendnvsne gtrlhdnqqt tilkettrie kgekdkkdrn aaivekntrp 121 rawpffwgrn kkdpepthni ptdadnntls rlanslnpap ltntyipykp dailirdkgv 181 ktakkltddi gnqfpnivvp sfdilpkqti wntvtstiwk wkteywdrrp ssrvregeeq 241 vqhsqnqlke etntvaneak deerlehnrg slfrvdpwkk inllsdyqsr pirvlivgvh 301 gffptkiirp figeptgtst kfvteaeeiv keyfdqhkvp ieiskialer egeifdrvdf 361 fyevmkhwsk einnsdfiyf vshsqgcpvt imllaklikn giinldnsqf fndeiqfcss 421 kkiisvlama ginngpfyga dqtlfvrayq tiekdslrel fefqkfdskq sqsfieglrt 481 iisnnvkitf vgsindqlvp lysstclfan hpnifraifi drgsqtpafi trivkiagsl 541 lnlgyndhgi ikeisgslag tltggghsti ynekqvyhlg ikfalettdl semypieysp 601 yklselganp yrlpwcmrgl myesnkhfsn eeikmlfkef eewepetkql kdiknrlngl 661 kyrl // LOCUS NP_013693 332 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-diphosphooligosaccharide--protein glycotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013693 VERSION NP_013693.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182377.1 REFERENCE 1 (residues 1 to 332) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 332) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 332) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 332) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09879. Method: conceptual translation. FEATURES Location/Qualifiers source 1..332 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..332 /product="dolichyl-diphosphooligosaccharide--protein glycotransferase" /calculated_mol_wt="37760" Region 37..329 /region_name="OST3_OST6" /note="OST3 / OST6 family, transporter family; pfam04756" /db_xref="CDD:461420" CDS 1..332 /gene="OST6" /locus_tag="YML019W" /coded_by="NM_001182377.1:1..999" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]" /experiment="EXISTENCE:direct assay:GO:0015035 protein-disulfide reductase activity [PMID:23416356]" /experiment="EXISTENCE:genetic interaction:GO:0006487 protein N-linked glycosylation [PMID:10358084]" /note="Subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p" /db_xref="GeneID:854989" /db_xref="SGD:S000004481" ORIGIN 1 mkwcstyiii wlaiifhkfq kstatashni ddilqlkddt gvitvtadny pllsrgvpgy 61 fnilyitmrg tnsngmscql chdfektyha vadvirsqap qslnlfftvd vnevpqlvkd 121 lklqnvphlv vyppaesnkq sqfewktspf yqyslvpena entlqfgdfl akilnisitv 181 pqafnvqefv yyfvacmvvf ifikkvilpk vtnkwklfsm ilslgillps itgykfvemn 241 aipfiardak nrimyfsggs gwqfgieifs vslmyivmsa lsvlliyvpk iscvsekmrg 301 llssflacvl fyffsyfisc yliknpgypi vf // LOCUS NP_013694 393 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML018C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013694 VERSION NP_013694.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182376.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09880. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..393 /product="uncharacterized protein" /calculated_mol_wt="43618" Region <138..369 /region_name="RhaT" /note="Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]; COG0697" /db_xref="CDD:440461" CDS 1..393 /locus_tag="YML018C" /coded_by="NM_001182376.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:22842922|PMID:26928762]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene; relative distribution to the vacuolar membrane decreases upon DNA replication stress; YML018C has a paralog, THI74, that arose from the whole genome duplication" /db_xref="GeneID:854990" /db_xref="SGD:S000004480" ORIGIN 1 mvskdqtsfn krwtlgllml glviilwvls sflinlifed dsyrkpffit ytntaafify 61 lfptakavvv nykdtgranv hrelimeeeg tgsdsnrsvd mtsplltnle agthanqkkr 121 ltlyetikls aefcilwfta nlvtnaslaf tsvasqtils ttssfftlfi gaichvesls 181 kskvlgsfis fvgiimvtks dshqryqrhi advsgddnda vqvlignlla lagavlygvy 241 stllkrevgd etrvnmkiff gfvglfnllf lwpslivldf fgwepfslpk dpkvvviifv 301 nclitfvsdf cwakamllts pltvtvglsi tiplamfgdv ifkhktmsal ylfgatlilg 361 sffiinksse eehfensita snyesvevpa ann // LOCUS NP_013695 593 aa linear PLN 30-JUN-2025 DEFINITION Psp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013695 VERSION NP_013695.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182375.1 REFERENCE 1 (residues 1 to 593) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 593) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 593) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 593) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 593) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09881. On Feb 2, 2004 this sequence version replaced NP_013695.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..593 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..593 /product="Psp2p" /calculated_mol_wt="65453" CDS 1..593 /gene="PSP2" /locus_tag="YML017W" /gene_synonym="MRS15" /coded_by="NM_001182375.1:1..1782" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Asn rich cytoplasmic protein with a role in clathrin suppresion; contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing" /db_xref="GeneID:854991" /db_xref="SGD:S000004479" ORIGIN 1 mgtnntsnnn gttkkmslee flgndtlges vwdeedinld aisnttnidi lkqtkagehq 61 rdghqqhphg ghgpmnrsrf snagpfgggs mgdfanhhhp lqhqqgppyi vkfsdlpprf 121 snfdiedlfq akftkfikfk lfweinknps istlksgsif dqnfkrdskv afvelytsrd 181 mdkilnywtt plkeiyhitt apaefedfkd ystkvklltd pkddagkpfi tktqrsksnp 241 fgsakpvdtq skildieekm enlhvedttt lraslipssd smattatgsk itilkkqtpt 301 eeeshsatpt pkplsysevv ersvvnetsk kgtplsklds palelqskpd ksdefkggde 361 qgfekggddk aqldvsndkd kgsetdvdkq ftfknvereh smsrtkyngn hnnnngnfrg 421 snryrggpng ssykgghnnr gnrggyrggs synnnnnntn dnnnnnnnss snnnngsryh 481 drqnneeglt sdssldasgn kkndftnsts ntqqysifkp asgflgqgnn dsirnngrgn 541 ynssgmnggs rgrgfgrgrg fgrgaynnrg srggrgssgn ysnynnrttd mpl // LOCUS NP_013696 692 aa linear PLN 30-JUN-2025 DEFINITION salt homeostasis regulator [Saccharomyces cerevisiae S288C]. ACCESSION NP_013696 VERSION NP_013696.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182374.1 REFERENCE 1 (residues 1 to 692) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 692) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 692) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 692) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09882. Method: conceptual translation. FEATURES Location/Qualifiers source 1..692 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..692 /product="salt homeostasis regulator" /EC_number="3.1.3.16" /calculated_mol_wt="77360" Region 362..653 /region_name="MPP_PP1_PPKL" /note="PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain; cd07414" /db_xref="CDD:277359" Site order(419,421,447,451,479..480,484..485,489,528,550..552, 561,575..577,603,627..631) /site_type="active" /db_xref="CDD:277359" Site order(419,421,447,479,528,603) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277359" Site order(451,484..485,489,550..552,561,575..577,627..631) /site_type="other" /note="natural toxin binding site [chemical binding]" /db_xref="CDD:277359" Site order(534,536,553,558,571,580,588..589,591..593,595..597, 612,616,643..644,646,648,650) /site_type="other" /note="MYPT1 binding site [polypeptide binding]" /db_xref="CDD:277359" CDS 1..692 /gene="PPZ1" /locus_tag="YML016C" /coded_by="NM_001182374.1:1..2079" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:7615085]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:8824289]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0006883 intracellular sodium ion homeostasis [PMID:7768897]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:21237705]" /note="Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance" /db_xref="GeneID:854992" /db_xref="SGD:S000004478" ORIGIN 1 mgnssskssk kdshsnsssr nprpqvsrte tshsvksaks nkssrsrrsl psssttntns 61 nvpdpstpsk pnlevnhqrh sshtnryhfp ssshshsnsq nellttpsss stkrpstsrr 121 ssyntkaaad lppsmiqmep kspilktnns sthvskhkss ysstyyenal tdddnddkdn 181 dishtkrfsr ssnsrpssir sgsvsrrksd vtheepnngs yssnnqenyl vqaltrsnsh 241 asslhsrkss fgsdgntays tplnspglsk ltdhsgeyft snstsslnhh ssrdiypskh 301 isndddiens sqlsnihasm envndknnni tdskkdpnee fndimqssgn knapkkfkkp 361 ididetiqkl ldagyaakrt knvclknnei lqicikarei flsqpsllel sppvkivgdv 421 hgqygdllrl ftkcgfppss nylflgdyvd rgkqsletil llfcykikyp enffllrgnh 481 ecanvtrvyg fydeckrrcn ikiwktfidt fntlplaaiv agkifcvhgg lspvlnsmde 541 irhvvrptdv pdfglindll wsdptdspne wednergvsy cynkvainkf lnkfgfdlvc 601 rahmvvedgy effndrslvt vfsapnycge fdnwgavmsv segllcsfel ldpldsaalk 661 qvmkkgrqer klanqqqqmm etsitndnes qq // LOCUS NP_013697 346 aa linear PLN 30-JUN-2025 DEFINITION TATA-binding protein-associated factor TAF11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013697 VERSION NP_013697.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182373.1 REFERENCE 1 (residues 1 to 346) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 346) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 346) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 346) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09883. Method: conceptual translation. FEATURES Location/Qualifiers source 1..346 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..346 /product="TATA-binding protein-associated factor TAF11" /calculated_mol_wt="40493" Region 31..230 /region_name="TAF40" /note="Transcription initiation factor TFIID, subunit TAF11 [Transcription]; COG5251" /db_xref="CDD:227576" CDS 1..346 /gene="TAF11" /locus_tag="YML015C" /gene_synonym="TAF40" /coded_by="NM_001182373.1:1..1041" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10818000]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:9083082]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]" /note="TFIID subunit (40 kDa); involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors" /db_xref="GeneID:854993" /db_xref="SGD:S000004477" ORIGIN 1 mtepqgpldt ipkvnyppil tianyfstkq midqvisedq dyvtwklqnl rtggtsinnq 61 lnkypkykyq ktrinqqdpd sinkvpenli fpqdilqqqt qnsnyedtnt nedeneklaq 121 deqfkllvtn ldkdqtnrfe vfhrtslnkt qvkklastva nqtisenirv flqavgkiya 181 geiielamiv knkwltsqmc iefdkrtkig yklkkylkkl tfsiienqqy kqdyqsdsvp 241 edepdfyfdd eevdkrettl gnsllqsksl qqsdhnsqdl klqlieqynk lvlqfnkldv 301 siekynnspl lpehireawr lyrlqsdtlp naywrtqgeg qgsmfr // LOCUS NP_013698 279 aa linear PLN 30-JUN-2025 DEFINITION tRNA (carboxymethyluridine(34)-5-O)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013698 VERSION NP_013698.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182372.1 REFERENCE 1 (residues 1 to 279) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 279) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 279) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 279) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09884. Method: conceptual translation. FEATURES Location/Qualifiers source 1..279 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..279 /product="tRNA (carboxymethyluridine(34)-5-O)-methyltransferase" /EC_number="2.1.1.229" /calculated_mol_wt="32308" Region 50..142 /region_name="Methyltransf_11" /note="Methyltransferase domain; pfam08241" /db_xref="CDD:462406" CDS 1..279 /gene="TRM9" /locus_tag="YML014W" /gene_synonym="KTI1" /coded_by="NM_001182372.1:1..840" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14645538]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:14645538]" /experiment="EXISTENCE:direct assay:GO:0016300 tRNA (uridine) methyltransferase activity [PMID:14645538]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:14645538]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0006448 regulation of translational elongation [PMID:27245397]" /note="tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses" /db_xref="GeneID:854994" /db_xref="SGD:S000004476" ORIGIN 1 meinqaaeke qeyvhkvyne iaphfsqtry kpwpivtqfl ktrpmgsigi dvgcgngkyl 61 gvnpdiyiig sdrsdgliec arginpsynl lvadglnlph knetfdfais iavvhhwstr 121 errvevirhv lsklrqggqa liycwaleqg ssrrgyhegm eqdvfvpwvl pkskskpktk 181 stppakvktr pkpnlmnipp kerseylqrw keeqqrsksl ddndekqqqd qeqereevky 241 ryyhlyrege laedcrqaga avhsegferd nwwvvaqkr // LOCUS NP_013699 584 aa linear PLN 30-JUN-2025 DEFINITION Ubx2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013699 VERSION NP_013699.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182371.1 REFERENCE 1 (residues 1 to 584) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 584) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 584) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 584) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09885. Method: conceptual translation. FEATURES Location/Qualifiers source 1..584 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..584 /product="Ubx2p" /calculated_mol_wt="66630" Region 18..58 /region_name="UBA_4" /note="UBA-like domain; pfam14555" /db_xref="CDD:464207" Region 431..570 /region_name="Ubl1_cv_Nsp3_N-like" /note="first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; cl28922" /db_xref="CDD:475130" CDS 1..584 /gene="UBX2" /locus_tag="YML013W" /gene_synonym="SEL1" /coded_by="NM_001182371.1:1..1755" /experiment="EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873065|PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:16179952]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:22454508|PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16179953]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:31118508]" /experiment="EXISTENCE:genetic interaction:GO:0034389 lipid droplet organization [PMID:22454508]" /experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:22454508]" /experiment="EXISTENCE:mutant phenotype:GO:0034982 mitochondrial protein processing [PMID:31118508]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:16179952]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:15258615]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:16179952]" /experiment="EXISTENCE:physical interaction:GO:0036503 ERAD pathway [PMID:16179952|PMID:16919153]" /note="Bridging factor involved in ER-associated protein degradation (ERAD); bridges the cytosolic Cdc48p-Npl1p-Ufd1p ATPase complex and the membrane associated Ssm4p and Hrd1p ubiquitin ligase complexes; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain; redistributes from the ER to lipid droplets during the diauxic shift and stationary phase; required for the maintenance of lipid homeostasis; required for mitochondrial protein translocation-associated degradation" /db_xref="GeneID:854995" /db_xref="SGD:S000004475" ORIGIN 1 mpvvnhedse fhlshteedk lnefqvitnf ppedlpdvvr llrnhgwqle palsryfdge 61 wkgepdqmge ptqtstpmae tlvppalgpr pllftaslpv vrplpanfrn dfrtiglngr 121 sntvwsmfes fsydgnpflf illlipriin rlsatiftff ctllslhsis gggnsgkpki 181 skvpkaptre thiplaeilg dtkdkdafce lksfkpdisf nealriakee fkfmllilvg 241 dtydtdtdtv dvnsklllek illnkktlqy lrkidndlii ylkcvhelep wlvarqlgvr 301 ntpeiflian vankashset lpsqrlsilg klkvnslnrf lqsltnvvek ytpelvvnkt 361 emhelrmsre ikklqedayk kslemdrika iekekslkha qdlklnstar qlkwlkacid 421 eiqpfettgk qatlqfrtss gkrfvkkfps mttlyqiyqs igchiylavy ssdpaewsna 481 lqdkirqlsa dddmlcfkeg qletatatti eelghiinne ltsfdlergk lefdfelvsp 541 fpkytvhpne hmsvdqvpql wpngsllvea ldeedeedee neeq // LOCUS NP_013701 211 aa linear PLN 30-JUN-2025 DEFINITION Erv25p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013701 VERSION NP_013701.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182369.1 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09886. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..211 /product="Erv25p" /calculated_mol_wt="23975" Region 20..206 /region_name="EMP24_GP25L" /note="emp24/gp25L/p24 family/GOLD; pfam01105" /db_xref="CDD:426051" CDS 1..211 /gene="ERV25" /locus_tag="YML012W" /coded_by="NM_001182369.1:1..636" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:physical interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:18283113]" /note="Member of the p24 family involved in ER to Golgi transport; role in misfolded protein quality control; forms a heterotrimeric complex with Erp1, Erp2p, and Emp24" /db_xref="GeneID:854997" /db_xref="SGD:S000004473" ORIGIN 1 mqvlqlwltt lislvvavqg lhfdiaastd peqvcirdfv tegqlvvadi hsdgsvgdgq 61 klnlfvrdsv gneyrrkrdf agdvrvafta psstafdvcf enqaqyrgrs lsraieldie 121 sgaeardwnk isaneklkpi evelrrveei tdeivdelty lknreerlrd tnestnrrvr 181 nfsilviivl sslgvwqvny lknyfktkhi i // LOCUS NP_013702 177 aa linear PLN 30-JUN-2025 DEFINITION Rad33p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013702 VERSION NP_013702.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182368.1 REFERENCE 1 (residues 1 to 177) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 177) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 177) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 177) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09887. Method: conceptual translation. FEATURES Location/Qualifiers source 1..177 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..177 /product="Rad33p" /calculated_mol_wt="20139" Region 18..141 /region_name="Rad33" /note="pfam08730" /db_xref="CDD:400876" CDS 1..177 /gene="RAD33" /locus_tag="YML011C" /coded_by="NM_001182368.1:1..534" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:16595192]" /note="Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus" /db_xref="GeneID:854998" /db_xref="SGD:S000004472" ORIGIN 1 mskstnvsye rvelfenpkv pievedeile kyaessldhd mtvnelprff kdlqleptiw 61 klvrnedvii egtdvidftk lvrctcqlli lmnnltvidd lwsmlirncg rdvdfpqval 121 rdhvlsvkdl qkisnligad qssgtiemis catdgkrlfm tyldfgcvlg klgylkm // LOCUS NP_013703 1063 aa linear PLN 30-JUN-2025 DEFINITION transcription elongation factor SPT5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013703 VERSION NP_013703.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182366.1 REFERENCE 1 (residues 1 to 1063) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1063) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1063) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1063) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1063) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1063) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1063) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09888. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1063 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1063 /product="transcription elongation factor SPT5" /calculated_mol_wt="115519" Region 2..>142 /region_name="PRK08581" /note="amidase domain-containing protein" /db_xref="CDD:236304" Region 180..280 /region_name="Spt5_N" /note="Spt5 transcription elongation factor, acidic N-terminal; pfam11942" /db_xref="CDD:463406" Region 287..373 /region_name="NGN_Euk" /note="Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1); cd09888" /db_xref="CDD:193577" Site order(298,301..302,304..306,308,312,322..327,338,340, 368..369,372) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:193577" Region 385..422 /region_name="KOW_Spt5_1" /note="KOW domain of Spt5, repeat 1; cd06081" /db_xref="CDD:240505" Region 534..582 /region_name="KOW_Spt5_2" /note="KOW domain of Spt5, repeat 2; cd06082" /db_xref="CDD:240506" Region 583..633 /region_name="KOW_Spt5_3" /note="KOW domain of Spt5, repeat 3; cd06083" /db_xref="CDD:240507" Region 708..748 /region_name="KOW_Spt5_4" /note="KOW domain of Spt5, repeat 4; cd06084" /db_xref="CDD:240508" Region 796..847 /region_name="KOW_Spt5_5" /note="KOW domain of Spt5, repeat 5; cd06085" /db_xref="CDD:240509" Region 902..1021 /region_name="CTD" /note="Spt5 C-terminal nonapeptide repeat binding Spt4; smart01104" /db_xref="CDD:215026" CDS 1..1063 /gene="SPT5" /locus_tag="YML010W" /coded_by="NM_001182366.1:1..3192" /experiment="EXISTENCE:direct assay:GO:0000245 spliceosomal complex assembly [PMID:31289129]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:35102600]" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:26945063]" /experiment="EXISTENCE:direct assay:GO:0001042 RNA polymerase I core binding [PMID:21467036]" /experiment="EXISTENCE:direct assay:GO:0001179 RNA polymerase I general transcription initiation factor binding [PMID:21467036]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:26945063]" /experiment="EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:27376968]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1840633]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:35102600]" /experiment="EXISTENCE:direct assay:GO:0010508 positive regulation of autophagy [PMID:31462158]" /experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:31289129]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:21467036]" /experiment="EXISTENCE:direct assay:GO:0030619 U1 snRNA binding [PMID:31289129]" /experiment="EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:31289129]" /experiment="EXISTENCE:direct assay:GO:0030621 U4 snRNA binding [PMID:31289129]" /experiment="EXISTENCE:direct assay:GO:0030623 U5 snRNA binding [PMID:31289129]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:26945063]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:16908835]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:35102600]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:26945063]" /experiment="EXISTENCE:direct assay:GO:0070990 snRNP binding [PMID:31289129]" /experiment="EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:20042611]" /experiment="EXISTENCE:genetic interaction:GO:2001208 negative regulation of transcription elongation by RNA polymerase I [PMID:21467039]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:20713510]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:19365074|PMID:26945063]" /experiment="EXISTENCE:mutant phenotype:GO:0044877 protein-containing complex binding [PMID:26945063]" /experiment="EXISTENCE:mutant phenotype:GO:2000232 regulation of rRNA processing [PMID:21949810]" /experiment="EXISTENCE:mutant phenotype:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:21467039]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:9450930]" /experiment="EXISTENCE:physical interaction:GO:0032044 DSIF complex [PMID:9450930]" /note="Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and in concert with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; interacts with DNA upstream of RNAPII and the non-template strand of the transcription bubble; Spt5p is the only transcription elongation factor conserved in all domains of life" /db_xref="GeneID:854999" /db_xref="SGD:S000004470" ORIGIN 1 msdnsdtnvs mqdhdqqfad pvvvpqstdt kdentsdkdt vdsgnvttte steraestsn 61 ippldgeeke aksepqqped naetaateqv sssngpatdd aqatlntdss eaneivkkee 121 gsderkrpre edtknsdgdt kdegdnkded ddeddddddd deddddeapt krrrqernrf 181 ldieaevsdd edededeeds elvregfith gddeddeasa pgarrddrlh rqldqdlnkt 241 seedaqrlak elrerygrss skqyraaaqd gyvpqrfllp svdtatiwgv rcrpgkekel 301 irkllkkkfn ldramgkkkl kilsifqrdn ytgriyieap kqsviekfcn gvpdiyisqk 361 llipvqelpl llkpnksddv aleegsyvri krgiykgdla mvdqisennl evmlkivprl 421 dygkfdeidp ttqqrksrrp tfahrappql fnptmalrld qanlykrddr hftyknedyi 481 dgylyksfri qhvetkniqp tveelarfgs kegavdltsv sqsikkaqaa kvtfqpgdri 541 evlngeqrgs kgivtrttkd iatiklngft tplefpistl rkifepgdhv tvingehqgd 601 aglvlmveqg qvtfmstqts revtitannl sksidttats seyalhdive lsaknvacii 661 qaghdifkvi detgkvstit kgsilskint ararvssvda ngneikigdt ivekvgsrre 721 gqvlyiqtqq ifvvskkive nagvfvvnps nveavaskdn mlsnkmdlsk mnpeiiskmg 781 ppssktfqqp iqsrggreva lgktvrirsa gykgqlgivk dvngdkatve lhsknkhiti 841 dkhkltyynr eggegityde lvnrrgrvpq armgpsyvsa prnmatggia agaaatssgl 901 sggmtpgwss fdggktpavn ahggsggggv sswggastwg gqgnggasaw ggagggasaw 961 ggqgtgatst wggasawgnk sswggastwa sggesngams twggtgdrsa yggastwggn 1021 nnnkstrdgg asawgnqddg nrsawnnqgn ksnyggnstw ggh // LOCUS NP_013705 70 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL33m MRPL39 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013705 VERSION NP_013705.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182364.1 REFERENCE 1 (residues 1 to 70) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 70) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 70) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 70) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09889. Method: conceptual translation. FEATURES Location/Qualifiers source 1..70 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..70 /product="mitochondrial 54S ribosomal protein bL33m MRPL39" /calculated_mol_wt="7841" Region 10..53 /region_name="Ribosomal_L33" /note="Ribosomal protein L33; cl00383" /db_xref="CDD:444877" CDS 1..70 /gene="MRPL39" /locus_tag="YML009C" /gene_synonym="bL33m" /coded_by="NM_001182364.1:1..213" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:2060626]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:855002" /db_xref="SGD:S000004468" ORIGIN 1 mvkvksknsv ikllstaasg ysryisikkg aplvtqvryd pvvkrhvlfk eakkrkvaer 61 kpldflrtak // LOCUS NP_013706 383 aa linear PLN 30-JUN-2025 DEFINITION sterol 24-C-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013706 VERSION NP_013706.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182363.1 REFERENCE 1 (residues 1 to 383) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 383) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 383) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 383) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09890. Method: conceptual translation. FEATURES Location/Qualifiers source 1..383 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..383 /product="sterol 24-C-methyltransferase" /EC_number="2.1.1.41" /calculated_mol_wt="43300" Region 72..222 /region_name="Cfa" /note="Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism]; COG2230" /db_xref="CDD:441831" Region 305..369 /region_name="Sterol_MT_C" /note="Sterol methyltransferase C-terminal; pfam08498" /db_xref="CDD:430034" CDS 1..383 /gene="ERG6" /locus_tag="YML008C" /gene_synonym="ISE1; LIS1; SED6; VID1" /coded_by="NM_001182363.1:1..1152" /experiment="EXISTENCE:direct assay:GO:0003838 sterol 24-C-methyltransferase activity [PMID:6363386|PMID:18563465]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:6363386|PMID:9450962|PMID:11298754]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:6363386]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:6363386|PMID:2677674]" /note="Delta(24)-sterol C-methyltransferase; converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to lipid particles, the plasma membrane-associated endoplasmic reticulum, and the mitochondrial outer membrane" /db_xref="GeneID:855003" /db_xref="SGD:S000004467" ORIGIN 1 msetelrkrq aqftrelhgd digkktglsa lmsknnsaqk eavqkylrnw dgrtdkdaee 61 rrledyneat hsyynvvtdf yeygwgssfh fsrfykgesf aasiarhehy laykagiqrg 121 dlvldvgcgv ggpareiarf tgcnviglnn ndyqiakaky yakkynlsdq mdfvkgdfmk 181 mdfeentfdk vyaieatcha pklegvysei ykvlkpggtf avyewvmtdk ydennpehrk 241 iayeielgdg ipkmfhvdva rkalkncgfe vlvsedladn ddeipwyypl tgewkyvqnl 301 anlatffrts ylgrqfttam vtvmeklgla pegskevtaa lenaavglva ggksklftpm 361 mlfvarkpen aetpsqtsqe atq // LOCUS NP_076904 36 aa linear PLN 30-JUN-2025 DEFINITION Min4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_076904 VERSION NP_076904.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184487.1 REFERENCE 1 (residues 1 to 36) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 36) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 36) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 36) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 36) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09891. Method: conceptual translation. FEATURES Location/Qualifiers source 1..36 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..36 /product="Min4p" /calculated_mol_wt="4279" CDS 1..36 /gene="MIN4" /locus_tag="YML007C-A" /coded_by="NM_001184487.1:1..111" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Mitochondrial hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to mitochondria" /db_xref="GeneID:855004" /db_xref="SGD:S000007621" ORIGIN 1 mvhfifialr smrfmrrlvr nlqylllpit ssllfi // LOCUS NP_013707 650 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcription factor YAP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013707 VERSION NP_013707.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182362.1 REFERENCE 1 (residues 1 to 650) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 650) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 650) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 650) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 650) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09892. Method: conceptual translation. FEATURES Location/Qualifiers source 1..650 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..650 /product="DNA-binding transcription factor YAP1" /calculated_mol_wt="72402" Region 65..126 /region_name="bZIP_YAP" /note="Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain; cd14688" /db_xref="CDD:269836" Site order(65..66,70..71,73..75,77..78,81..82,84..85) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269836" Region 69..126 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269836" Site order(88..89,92..93,95..96,99..100,102..103,106,109..110, 113..114,117,120..121,123..124) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269836" Region <587..647 /region_name="PAP1" /note="Transcription factor PAP1; pfam08601" /db_xref="CDD:369990" CDS 1..650 /gene="YAP1" /locus_tag="YML007W" /gene_synonym="PAR1; PDR4; SNQ3" /coded_by="NM_001182362.1:1..1953" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:11056165]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:27838435|PMID:12582119|PMID:11914276|PMID:24034606|P MID:22842922|PMID:9130715]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9130715|PMID:24034606|PMID:11914276|PMID:12582119|PM ID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11056165]" /experiment="EXISTENCE:direct assay:GO:0034599 cellular response to oxidative stress [PMID:11056165]" /experiment="EXISTENCE:mutant phenotype:GO:0000304 response to singlet oxygen [PMID:16862604]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10809786]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15575969]" /experiment="EXISTENCE:mutant phenotype:GO:0046685 response to arsenic-containing substance [PMID:15575969]" /experiment="EXISTENCE:mutant phenotype:GO:1900101 regulation of endoplasmic reticulum unfolded protein response [PMID:27373166]" /note="Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; relative distribution to the nucleus increases upon DNA replication stress; YAP1 has a paralog, CAD1, that arose from the whole genome duplication" /db_xref="GeneID:855005" /db_xref="SGD:S000004466" ORIGIN 1 msvstakrsl dvvspgslae fegsksrhde ienehrrtgt rdgedseqpk kkgsktskkq 61 dldpetkqkr taqnraaqra frerkerkmk elekkvqsle siqqqnevea tflrdqlitl 121 vnelkkyrpe trndskvley larrdpnlhf sknnvnhsns epidtpnddi qenvkqkmnf 181 tfqypldndn dndnsknvgk qlpspndpsh sapmpinqtq kklsdatdss satldslsns 241 ndvlnntpns stsmdwldnv iytnrfvsgd dgsnsktknl dsnmfsndfn fenqfdeqvs 301 efcskmnqvc gtrqcpipkk pisaldkevf asssilssns paltntwesh snitdntpan 361 viatdatkye nsfsgfgrlg fdmsanhyvv ndnstgstds tgstgnknkk nnnnsddvlp 421 fisespfdmn qvtnffspgs tgignnaasn tnpsllqssk edipfinanl afpddnstni 481 qlqpfsesqs qnkfdydmff rdsskegnnl fgefledddd dkkaanmsdd essliknqli 541 neepelpkqy lqsvpgnese isqkngsslq nadkinngnd ndndndvvps kegsllrcse 601 iwdritthpk ysdidvdglc selmakakcs ergvvinaed vqlalnkhmn // LOCUS NP_013708 774 aa linear PLN 30-JUN-2025 DEFINITION Gis4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013708 VERSION NP_013708.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182361.1 REFERENCE 1 (residues 1 to 774) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 774) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 774) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 774) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 774) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 774) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 774) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09893. Method: conceptual translation. FEATURES Location/Qualifiers source 1..774 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..774 /product="Gis4p" /calculated_mol_wt="87009" CDS 1..774 /gene="GIS4" /locus_tag="YML006C" /coded_by="NM_001182361.1:1..2325" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17030993]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0035556 intracellular signal transduction [PMID:10628841]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:17030993]" /note="CAAX box containing hypothetical protein; proposed to be involved in the RAS/cAMP signaling pathway" /db_xref="GeneID:855006" /db_xref="SGD:S000004465" ORIGIN 1 mqksvrvgdy fdnddnglws wyltnlrlgd feelignqlk ytllkrflns hfygdnnisa 61 rpnkkillvs ipenvhedis ileiflkdyf hleklehiqi sklthshcyn henhylltdn 121 lnnfqdptfl efastswqvq knskalnnnn rnsippptis sskasngkle snvsddqwsn 181 intqtstatr tntntrtlts pdtvdinvts vnsqsnnndt pqdnenevde edatssivln 241 fshsrtvdsk pnrlpkifps ytnedytpsh seimsidsfa gedvsstypg qdlslttarr 301 edesgqdeve dhysrvshdl gdesidqasy smessvsyts yssssnsssa hyslssssrg 361 npkrenidht natyvselss itssidnltt sttpeeednl ihhnydaqgy gsgeddgeev 421 yddedlsssd ysvlsilpsi sicdslgyfr lvlqsiliqd pdtkeiftai rqsnnkptma 481 svtddwllyd snfsmnnlqi ltlqdlldik rsfpkilfyt mvivtnsgkq veeefknpny 541 dnregiskeq pldselsltn dpqqyfptay nngyndyidd eddeddgdda slseqsgpqm 601 yiptrmesnv ttahrsirtv nsigewafnr hnsvtkidks nsneldnskt gestvlssep 661 hpmtqlsnsn ttssnfshsl ktknshkpns kgnnesnskn elkkikssin amsaversks 721 lplptllksl sgidnpthat nkdrkrwkfq mnrfknhkns gsagtdksqr caim // LOCUS NP_013709 462 aa linear PLN 30-JUN-2025 DEFINITION tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013709 VERSION NP_013709.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182360.1 REFERENCE 1 (residues 1 to 462) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 462) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 462) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 462) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09894. Method: conceptual translation. FEATURES Location/Qualifiers source 1..462 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..462 /product="tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase" /EC_number="2.5.1.114" /calculated_mol_wt="52596" Region <255..459 /region_name="Trm5" /note="tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; COG2520" /db_xref="CDD:442010" CDS 1..462 /gene="TRM12" /locus_tag="YML005W" /gene_synonym="TYW2" /coded_by="NM_001182360.1:1..1389" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:16005430]" /experiment="EXISTENCE:direct assay:GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups [PMID:16642040]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:16005430]" /experiment="EXISTENCE:mutant phenotype:GO:0031591 wybutosine biosynthetic process [PMID:16642040|PMID:17150819]" /note="S-adenosylmethionine-dependent methyltransferase; required for wybutosine formation in phenylalanine-accepting tRNA; member of the seven beta-strand family" /db_xref="GeneID:855008" /db_xref="SGD:S000004464" ORIGIN 1 msdetmpvef lvsdkrllkt ikvkletngl fvtpiysdnd nkvikssied lnhplavein 61 niagvkarfh esgnlerseg hlkhqsnsit eftksflkdh glandkifls hlldhlplky 121 tiyppvvlfn nstvrsfnhp iwqkafqlkl fdpneyyrel lcflspgkps kgtslhpnnr 181 llthlainnp iteadvlrrp fniqplygkl iddsilddnd ntlwenpsqe qlnssiwckv 241 iqngvtqiws pvftmfsrgn ikekkrvltt fpdicnndvv dlyagigyft fsyltkgart 301 lfafelnpws veglkrglka ngfnksgnch vfqesnemcv qrlteflsqn pgfrlrirhi 361 nlgllpsskq gwplaikliy lqgaslekvt mhihenvhid aiedgsfekn viveldaine 421 sialirnrgi klqfvrskle riktfapdiw hvcvdvdviv st // LOCUS NP_013710 326 aa linear PLN 30-JUN-2025 DEFINITION lactoylglutathione lyase GLO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013710 VERSION NP_013710.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182359.1 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09895. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..326 /product="lactoylglutathione lyase GLO1" /EC_number="4.4.1.5" /calculated_mol_wt="37078" Region 23..165 /region_name="GlxI_Zn" /note="Glyoxalase I that uses Zn(++) as cofactor; cd07233" /db_xref="CDD:319900" Site order(23..27,29,33..34,37..38,41..42,45,48,51..52,62,66,86, 88..89,93..94,114..123,131,160,163) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:319900" Site order(25,29,54,59,61,89,91,93,117,141,151,153,161,163) /site_type="active" /db_xref="CDD:319900" Site order(29,54,59,61,91,93,141,151,153,161) /site_type="other" /note="glutathione binding site [chemical binding]" /db_xref="CDD:319900" Region 183..320 /region_name="GlxI_Zn" /note="Glyoxalase I that uses Zn(++) as cofactor; cd07233" /db_xref="CDD:319900" Site order(183..187,189,193..194,197..198,201..202,205,208, 211..212,222,226,239,241..242,246..247,266..275,283,315, 318) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:319900" Site order(185,189,214,219,221,242,244,246,269,300,306,308,316, 318) /site_type="active" /db_xref="CDD:319900" Site order(189,214,219,221,244,246,300,306,308,316) /site_type="other" /note="glutathione binding site [chemical binding]" /db_xref="CDD:319900" CDS 1..326 /gene="GLO1" /locus_tag="YML004C" /coded_by="NM_001182359.1:1..981" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:8824231]" /experiment="EXISTENCE:mutant phenotype:GO:0004462 lactoylglutathione lyase activity [PMID:8824231]" /experiment="EXISTENCE:mutant phenotype:GO:0006749 glutathione metabolic process [PMID:8824231]" /note="Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; required for full activity of O-acetyl homoserine sulfhydrylase, Met17p; expression regulated by methylglyoxal levels and osmotic stress" /db_xref="GeneID:855009" /db_xref="SGD:S000004463" ORIGIN 1 mstdstrypi qiekasndpt lllnhtclrv kdpartvkfy tehfgmklls rkdfeeakfs 61 lyflsfpkdd ipknkngepd vfsahgvlel thnwgteknp dykinngnee phrgfghicf 121 svsdinktce elesqgvkfk krlsegrqkd iafalgpdgy wielitysre gqeypkgsvg 181 nkfnhtmiri knptrslefy qnvlgmkllr tsehesakft lyflgygvpk tdsvfscesv 241 lelthnwgte ndpnfhyhng nsepqgyghi ciscddagal ckeievkygd kiqwspkfnq 301 grmkniaflk dpdgysievv phglia // LOCUS NP_013711 290 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YML003W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013711 VERSION NP_013711.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182358.1 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09896. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..290 /product="uncharacterized protein" /calculated_mol_wt="33840" CDS 1..290 /locus_tag="YML003W" /gene_synonym="VRL1" /coded_by="NM_001182358.1:1..873" /note="Truncated 5' end of YML002W; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W" /db_xref="GeneID:855010" /db_xref="SGD:S000004462" ORIGIN 1 msvyhlptll nplvnaifnc pepersplkk lfanlktrrf illappseyl lnyhdvkskl 61 plhdlcynae finsyillmt ensyintnsr dshyetldgk tvviqwknnv ihalngfhir 121 rrlkiletki lpnfndyfeg aadfiilfid qplncefvpn dylqcfhnye kipknahamp 181 nlsidsfqqe rssfenilhi hparltqlgq lfssyrtlap gddpsrsife sivqqafdgm 241 ksdslfknfs nlydlihdyf elnlyddiws rltthfkghe vdtekinifq // LOCUS NP_013712 737 aa linear PLN 30-JUN-2025 DEFINITION Vrl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013712 VERSION NP_013712.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182357.1 REFERENCE 1 (residues 1 to 737) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 737) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 737) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 737) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09897. Method: conceptual translation. FEATURES Location/Qualifiers source 1..737 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..737 /product="Vrl1p" /calculated_mol_wt="84471" Region <8..79 /region_name="VPS9" /note="Vacuolar sorting protein 9 (VPS9) domain; cl19569" /db_xref="CDD:473191" Region 83..349 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" CDS 1..737 /gene="VRL1" /locus_tag="YML002W" /coded_by="NM_001182357.1:1..2214" /note="hypothetical protein; expression induced by heat and by calcium shortage; in many strains, YML002W is continuous with YML003W, and is predicted to encode a single protein of 1090 aa with a full-length VPS9 domain; in strains S288C, W303, and CEN.PK, a single thymine residue is deleted near the 3' end of YML003W at ChrXIII:264337, causing a frameshift and premature stop codon, truncating YML003W" /db_xref="GeneID:855011" /db_xref="SGD:S000004461" ORIGIN 1 mdshqlelpd glnnmtmdad tlislfvlvv crseqkhlks hlyylqnfsn nssstkfgil 61 gyavstleav vcyfedfnkn tgnvakantl cektknlldk lscenptnev edlatykdil 121 tyrneqgqsi lsicitnhkn yilldilsey endfpvedll edetidgstl liesikagnl 181 eaakvlikim lfncteeelv syinktdkya rtvahylthe mdilksigny idwkrknssg 241 qtplfsifrs ydqpnyeemv ktafdiantw yrkhnslfdy ldhtdnkgns llhvlktnip 301 illqltkldi neenykgltp lmvyvkykrl snidaitkdr rlilekvqns tfftcfdyak 361 dhsvlskige rgvkdslfgl iyfhslryhn lnattnitsv snaekpfatt vinmktiqgl 421 lrsilkdnpf tflplntyid eishlnrsdl tiigktdvts llhqltncfn vllflkkipe 481 nlftdeasil ywmrintskr nqkpsgkenp ktmepeeinm iqsflrfnfd eissfkasln 541 ilrkvlifin lksddfeday kglnemgrkl inseassafk giitnhnmfs elslaallen 601 vrfleqctiq lssfvqiilf ekipnwwkhy geflalhksy rkafpnmvkp ksasdtssra 661 plggfietkr eqseqrlavq ikasskmlke lgseifvahe rlaeelsnym efrkacldqr 721 slvafattni svlqecv // LOCUS NP_013713 208 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase YPT7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013713 VERSION NP_013713.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182356.1 REFERENCE 1 (residues 1 to 208) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 208) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 208) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 208) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09898. Method: conceptual translation. FEATURES Location/Qualifiers source 1..208 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..208 /product="Rab family GTPase YPT7" /calculated_mol_wt="22912" Region 9..182 /region_name="Rab7" /note="Rab GTPase family 7 (Rab7); cd01862" /db_xref="CDD:206655" Site 9..10 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206655" Site 15..22 /site_type="other" /note="G1 box" /db_xref="CDD:206655" Site order(17..23,33,35,40,67,126..127,129,158..160) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206655" Site order(17,42,44..45,64,68,70..73,76..77,80) /site_type="active" /note="GDI interaction site [active]" /db_xref="CDD:206655" Site order(23..34,36..39) /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206655" Site order(33,38..46) /site_type="other" /note="Switch I region" /db_xref="CDD:206655" Site order(38,42..49,57,59) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206655" Site 40 /site_type="other" /note="G2 box" /db_xref="CDD:206655" Site order(41,43..45,61,63,70..71,74,78,80..83,176) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206655" Site 41..45 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206655" Site 59..63 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206655" Site 64..67 /site_type="other" /note="G3 box" /db_xref="CDD:206655" Site order(67,69..79) /site_type="other" /note="Switch II region" /db_xref="CDD:206655" Site 70..75 /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206655" Site 78..82 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206655" Site 87..92 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206655" Site 118..123 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206655" Site 126..129 /site_type="other" /note="G4 box" /db_xref="CDD:206655" Site 158..160 /site_type="other" /note="G5 box" /db_xref="CDD:206655" Site 174..182 /site_type="other" /note="Rab subfamily motif 4 (RabSF4)" /db_xref="CDD:206655" CDS 1..208 /gene="YPT7" /locus_tag="YML001W" /gene_synonym="AST4; VAM4" /coded_by="NM_001182356.1:1..627" /experiment="EXISTENCE:direct assay:GO:0000011 vacuole inheritance [PMID:7489715]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11853670]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22593205|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005771 multivesicular body [PMID:38536036]" /experiment="EXISTENCE:direct assay:GO:0016192 vesicle-mediated transport [PMID:9015302]" /experiment="EXISTENCE:direct assay:GO:0043254 regulation of protein-containing complex assembly [PMID:32160129]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:22593205]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026035]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:1473149]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:11598008|PMID:7489715]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0072665 protein localization to vacuole [PMID:22593205]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:20604902|PMID:11062257|PMID:21325627|PMID:18809726]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:22593205]" /note="Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7" /db_xref="GeneID:855012" /db_xref="SGD:S000004460" ORIGIN 1 mssrkknilk viilgdsgvg ktslmhryvn dkysqqykat igadfltkev tvdgdkvatm 61 qvwdtagqer fqslgvafyr gadccvlvyd vtnassfeni kswrdeflvh anvnspetfp 121 fvilgnkida eeskkivsek saqelakslg diplfltsak nainvdtafe eiarsalqqn 181 qadteafedd yndainirld gennscsc // LOCUS NP_013714 705 aa linear PLN 30-JUN-2025 DEFINITION polo kinase CDC5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013714 VERSION NP_013714.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182497.1 REFERENCE 1 (residues 1 to 705) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 705) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 705) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 705) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09899. Method: conceptual translation. FEATURES Location/Qualifiers source 1..705 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..705 /product="polo kinase CDC5" /EC_number="2.7.11.21" /calculated_mol_wt="80900" Region 80..337 /region_name="STKc_PLK" /note="Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; cd14099" /db_xref="CDD:271001" Site order(88..92,96,108,110,142,158..161,165,167,204,206, 208..209,211,222,225,241..244) /site_type="active" /db_xref="CDD:271001" Site order(88..92,96,108,110,142,159..161,211,222) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271001" Site order(92,165,167,204,206,208,225,241..244) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271001" Site order(221..229,234..244) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271001" Region 510..601 /region_name="POLO_box_1" /note="First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; cd13118" /db_xref="CDD:240561" Site order(516..519,592,594..598) /site_type="other" /note="phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:240561" Region 613..698 /region_name="POLO_box_2" /note="Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5; cd13117" /db_xref="CDD:240560" Site order(620,639,641,643) /site_type="other" /note="phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:240560" CDS 1..705 /gene="CDC5" /locus_tag="YMR001C" /gene_synonym="MSD2; PKX2" /coded_by="NM_001182497.1:1..2118" /experiment="EXISTENCE:direct assay:GO:0000922 spindle pole [PMID:10594031]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:12637549|PMID:17122856|PMID:8321244|PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:21498574]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9819423]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10594031]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:27226485]" /experiment="EXISTENCE:direct assay:GO:0044732 mitotic spindle pole body [PMID:32553169]" /experiment="EXISTENCE:direct assay:GO:0051219 phosphoprotein binding [PMID:27325700]" /experiment="EXISTENCE:genetic interaction:GO:0010458 exit from mitosis [PMID:21937712]" /experiment="EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:18500339]" /experiment="EXISTENCE:genetic interaction:GO:0070194 synaptonemal complex disassembly [PMID:18832066]" /experiment="EXISTENCE:genetic interaction:GO:1902542 regulation of protein localization to mitotic spindle pole body [PMID:21937712]" /experiment="EXISTENCE:genetic interaction:GO:1904750 negative regulation of protein localization to nucleolus [PMID:14551257]" /experiment="EXISTENCE:mutant phenotype:GO:0000712 resolution of meiotic recombination intermediates [PMID:12717442]" /experiment="EXISTENCE:mutant phenotype:GO:0004672 protein kinase activity [PMID:8321244|PMID:17122856]" /experiment="EXISTENCE:mutant phenotype:GO:0005935 cellular bud neck [PMID:16763112]" /experiment="EXISTENCE:mutant phenotype:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:18500339]" /experiment="EXISTENCE:mutant phenotype:GO:0035025 positive regulation of Rho protein signal transduction [PMID:16763112]" /experiment="EXISTENCE:mutant phenotype:GO:0090306 meiotic spindle assembly [PMID:24386320|PMID:20237423]" /experiment="EXISTENCE:mutant phenotype:GO:0110083 positive regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly [PMID:16763112]" /experiment="EXISTENCE:mutant phenotype:GO:1903353 regulation of nucleus organization [PMID:25454593]" /experiment="EXISTENCE:mutant phenotype:GO:1904749 regulation of protein localization to nucleolus [PMID:33481703]" /experiment="EXISTENCE:mutant phenotype:GO:1904750 negative regulation of protein localization to nucleolus [PMID:14551257]" /experiment="EXISTENCE:physical interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:27325700]" /note="Polo-like kinase required for mitotic exit; regulates mitotic spindle assembly, nuclear shape, and protein localization to the nucleolus and SPBs; controls targeting and activation of Rho1p at the division site via Rho1p-GEFs; role in adaptation to DNA damage promotes genome instability during replicative senescence; regulates meiotic commitment, spindle assembly, chiasmata formation, recombination intermediate resolution and SC disassembly; human homologs PLK1 and PLK3 complement cdc5 mutants" /db_xref="GeneID:855013" /db_xref="SGD:S000004603" ORIGIN 1 mslgplkain dkqlntrskl vhtpikgnta dlvgkenhfk qtkrldpnnd hhhqpaqkkk 61 reklsalckt ppsliktrgk dyhrghflge ggfarcfqik ddsgeifaak tvakasikse 121 ktrkkllsei qihksmshpn ivqfidcfed dsnvyillei cpngslmell krrkvltepe 181 vrffttqicg aikymhsrrv ihrdlklgni ffdsnynlki gdfglaavla neserkytic 241 gtpnyiapev lmgkhsghsf evdiwslgvm lyalligkpp fqardvntiy erikcrdfsf 301 prdkpisdeg kilirdilsl dpierpslte imdyvwfrgt fppsipstvm seapnfedip 361 eeqslvnfkd cmeksllles mssdkiqrqk rdyissikss idkleeyhqn rpflphslsp 421 ggtkqkykev vdieaqrrln dlarearirr aqqavlrkel iatstnviks eislrilase 481 chltlngive aeaqykmggl pksrlpkikh pmivtkwvdy snkhgfsyql stedigvlfn 541 ngttvlrlad aeefwyisyd dregwvashy llsekprels rhlevvdffa kymkanlsrv 601 stfgreeyhk ddvflrrytr ykpfvmfels dgtfqfnfkd hhkmaisdgg klvtyispsh 661 esttyplvev lkygeipgyp esnfrekltl ikeglkqkst ivtvd // LOCUS NP_878140 76 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR001C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878140 VERSION NP_878140.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184613.1 REFERENCE 1 (residues 1 to 76) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 76) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 76) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 76) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09900. Method: conceptual translation. FEATURES Location/Qualifiers source 1..76 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..76 /product="uncharacterized protein" /calculated_mol_wt="8579" CDS 1..76 /locus_tag="YMR001C-A" /coded_by="NM_001184613.1:1..231" /note="hypothetical protein" /db_xref="GeneID:1466498" /db_xref="SGD:S000028691" ORIGIN 1 mifectsfet rhilnsysca tqlsyntyri tekvnpiqaa vsknnkpfvs nsdsaffpif 61 ssfnfvaytt ltfkkt // LOCUS NP_013715 156 aa linear PLN 30-JUN-2025 DEFINITION Mix17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013715 VERSION NP_013715.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182498.1 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09901. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..156 /product="Mix17p" /calculated_mol_wt="16538" Region <12..>87 /region_name="COG3416" /note="Uncharacterized conserved protein, DUF2076 domain [Function unknown]" /db_xref="CDD:442642" Region 118..152 /region_name="CHCH" /note="CHCH domain; pfam06747" /db_xref="CDD:429096" CDS 1..156 /gene="MIX17" /locus_tag="YMR002W" /gene_synonym="MIC17" /coded_by="NM_001182498.1:1..471" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:17095012]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:19703468]" /note="Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855014" /db_xref="SGD:S000004604" ORIGIN 1 marsrgssrp isrsrptqtr sastmaapvh pqqqqqpnay shppaagaqt rqpgmfaqma 61 staagvavgs tightlgagi tgmfsgsgsd sapveqqqqn mantsgqtqt dqqlgrtcei 121 darnftrcld enngnfqicd yylqqlkacq eaarqy // LOCUS NP_013716 198 aa linear PLN 30-JUN-2025 DEFINITION Aim34p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013716 VERSION NP_013716.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182499.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09902. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..198 /product="Aim34p" /calculated_mol_wt="22611" Region 69..103 /region_name="SAP" /note="SAP domain; pfam02037" /db_xref="CDD:460424" CDS 1..198 /gene="AIM34" /locus_tag="YMR003W" /coded_by="NM_001182499.1:1..597" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="hypothetical protein; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss" /db_xref="GeneID:855015" /db_xref="SGD:S000004605" ORIGIN 1 msisllgriv sqqfsgiraa epgrslylpf tlllkqpgay kvslhryvhs tqtkshlsfl 61 mnnnditpfq kftvkvlkeq cksrglklsg rksdllqrli thdscsnkks svkinepkkk 121 rilindpiki tkklvsdktf rtieknissl qntpvietpc dvhshlqprd rifllgffml 181 sclwwnlepq eskptidh // LOCUS NP_013717 511 aa linear PLN 30-JUN-2025 DEFINITION Mvp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013717 VERSION NP_013717.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182500.1 REFERENCE 1 (residues 1 to 511) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 511) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 511) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 511) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09903. Method: conceptual translation. FEATURES Location/Qualifiers source 1..511 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..511 /product="Mvp1p" /calculated_mol_wt="59526" Region 1..511 /region_name="COG5391" /note="Phox homology (PX) domain protein [Intracellular trafficking and secretion / General function prediction only]" /db_xref="CDD:227680" CDS 1..511 /gene="MVP1" /locus_tag="YMR004W" /coded_by="NM_001182500.1:1..1536" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21954159]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:7862158]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:24567361]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:direct assay:GO:0097320 plasma membrane tubulation [PMID:24567361]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:7862158]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:24567361]" /note="Protein required for sorting proteins to the vacuole; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or early elongation of specific genes; interacts with 'foot domain' of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855016" /db_xref="SGD:S000004606" ORIGIN 1 mdnyegsdpw ntssnawtkd ddhvvsttns epslngisge fntlnfstpl dtneedtgfl 61 ptndvleesi wddsrnplga tgmsqtpnia anetvidknd ardqnieese adlldwtnnv 121 rktyrpldad iiiieeiper egllfkhany lvkhlialps tspseertvv rrysdflwlr 181 eillkrypfr mipelppkri gsqnadqlfl kkrriglsrf inlvmkhpkl snddlvltfl 241 tvrtdltswr kqatydtsne fadkkisqef mkmwkkefae qwnqaascid tsmelwyrit 301 lllerhekri mqmvhernff etlvdnfsev tpklypvqqn dtildinnnl siikkhlett 361 ssickqetee isgtlspkfk iftdillslr slferykima annvvelqrh velnkekles 421 mkgkpdvsga eydrikkiiq kdrrsiieqs nrawlirqci leeftifqet qflitrafqd 481 waklnsnhag lklneweklv tsimdmpisr e // LOCUS NP_013718 388 aa linear PLN 30-JUN-2025 DEFINITION Taf4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013718 VERSION NP_013718.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182501.1 REFERENCE 1 (residues 1 to 388) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 388) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 388) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 388) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 388) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 388) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 388) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09904. Method: conceptual translation. FEATURES Location/Qualifiers source 1..388 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..388 /product="Taf4p" /calculated_mol_wt="42205" Region 144..383 /region_name="TAF4" /note="Transcription initiation factor TFIID component TAF4 family; pfam05236" /db_xref="CDD:461598" CDS 1..388 /gene="TAF4" /locus_tag="YMR005W" /gene_synonym="MPT1; TAF48; TSG2" /coded_by="NM_001182501.1:1..1167" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:12600943]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12501245]" /note="TFIID subunit (48 kDa); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate" /db_xref="GeneID:855017" /db_xref="SGD:S000004607" ORIGIN 1 manspkkpsd gtgvsasdtp kyqhtvpetk pafnlspgka selshslpsp sqikstahvs 61 sthndaagnt ddsvlpknvs pttnlrvesn gdtnnmfssp aglalpkkdd kkknkgtska 121 dskdgkasns sgqnaqqqsd pnkmqdvlfs agidvreeea llnssinask sqvqtnnvki 181 pnhlpflhpe qvsnymrkvg keqnfnltpt knpeildmms sacenymrdi ltnaivisrh 241 rrkavkinsg rrsevsaalr aialiqkkee errvkkrial glekedyenk idseetlhra 301 snvtaglrag skkqygwlts svnkptslga kssgkvasdi targesglkf reareepgiv 361 mrdllfalen rrnsvqtiis kgyakird // LOCUS NP_013719 706 aa linear PLN 30-JUN-2025 DEFINITION lysophospholipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013719 VERSION NP_013719.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182502.1 REFERENCE 1 (residues 1 to 706) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 706) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 706) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 706) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09905. Method: conceptual translation. FEATURES Location/Qualifiers source 1..706 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..706 /product="lysophospholipase" /EC_number="3.1.1.5" /calculated_mol_wt="75325" Region 17..582 /region_name="PLAc" /note="Cytoplasmic phospholipase A2, catalytic subunit; smart00022" /db_xref="CDD:214474" CDS 1..706 /gene="PLB2" /locus_tag="YMR006C" /coded_by="NM_001182502.1:1..2121" /experiment="EXISTENCE:direct assay:GO:0004622 phosphatidylcholine lysophospholipase activity [PMID:10497163]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:10497163]" /experiment="EXISTENCE:direct assay:GO:0006650 glycerophospholipid metabolic process [PMID:10497163]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953|PMID:15781460]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0004622 phosphatidylcholine lysophospholipase activity [PMID:10497163]" /experiment="EXISTENCE:mutant phenotype:GO:0006650 glycerophospholipid metabolic process [PMID:10497163]" /note="Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine" /db_xref="GeneID:855018" /db_xref="SGD:S000004608" ORIGIN 1 mqlrnilqas slisglslaa dsssttgdgy apsiipcpsd dtslvrnasg lstaetdwlk 61 krdaytkeal hsflsratsn fsdtsllstl fssnssnvpk igiacsgggy ramlggagmi 121 aamdnrtdga nehglggllq sstylsglsg gnwltgtlaw nnwtsvqeiv dhmsesdsiw 181 nitksivnpg gsnltytier wesivqevqa ksdagfnisl sdlwaralsy nffpslpdag 241 saltwsslrd vdvfkngemp lpitvadgry pgttvinlna tlfeftpfem gswdpslnaf 301 tdvkylgtnv tngkpvnkdq cvsgydnagf viatsaslfn efsleastst yykminsfan 361 kyvnnlsqdd ddiaiyaanp fkdtefvdrn ytssivdadd lflvdggedg qnlplvplik 421 kerdldvvfa ldisdntdes wpsgvcmtnt yerqyskqgk gmafpyvpdv ntflnlgltn 481 kptffgcdak nltdleyipp lvvyipntkh sfngnqstlk mnynvterlg mirngfeaat 541 mgnftddsnf lgcigcaiir rkqeslnatl ppectkcfad ycwngtlsts anpelsgnst 601 yqsgaiasai seatdgipit allgsstsgn ttsnsttsts snvtsnsnss snttlnsnss 661 sssissstar sssstankan aaaisyantn tlmsllgait alfgli // LOCUS NP_001335804 126 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR007W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335804 VERSION NP_001335804.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348864.1 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80324. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..126 /product="uncharacterized protein" /calculated_mol_wt="14399" CDS 1..126 /locus_tag="YMR007W" /coded_by="NM_001348864.1:1..381" /note="hypothetical protein; conserved among S. cerevisiae strains; YMR007W is not an essential gene" /db_xref="GeneID:855019" /db_xref="SGD:S000004609" ORIGIN 1 mrkkcpqgkk llkkatrpfv gafrrrirak knlisqfgqt gcigcdgkfs igitiekyvl 61 nlvvriiivf alcritelsv fdsslrcksr ktrlskaark ketdhfheqc ryvevkfglq 121 maylqs // LOCUS NP_013721 664 aa linear PLN 30-JUN-2025 DEFINITION lysophospholipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013721 VERSION NP_013721.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182504.1 REFERENCE 1 (residues 1 to 664) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 664) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 664) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 664) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09906. Method: conceptual translation. FEATURES Location/Qualifiers source 1..664 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..664 /product="lysophospholipase" /EC_number="3.1.1.5" /calculated_mol_wt="71537" Region 16..580 /region_name="PLAc" /note="Cytoplasmic phospholipase A2, catalytic subunit; smart00022" /db_xref="CDD:214474" CDS 1..664 /gene="PLB1" /locus_tag="YMR008C" /coded_by="NM_001182504.1:1..1995" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:25258318]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:8051052]" /experiment="EXISTENCE:direct assay:GO:0042597 periplasmic space [PMID:8051052]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0004622 phosphatidylcholine lysophospholipase activity [PMID:8051052]" /experiment="EXISTENCE:mutant phenotype:GO:0006650 glycerophospholipid metabolic process [PMID:8051052]" /experiment="EXISTENCE:mutant phenotype:GO:0036151 phosphatidylcholine acyl-chain remodeling [PMID:23501167]" /note="Phospholipase B (lysophospholipase) involved in lipid metabolism; required for efficient acyl chain remodeling of newly synthesized phosphatidylethanolamine-derived phosphatidylcholine; required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol; PLB1 has a paralog, PLB3, that arose from the whole genome duplication" /db_xref="GeneID:855020" /db_xref="SGD:S000004610" ORIGIN 1 mklqsllvsa avltsltenv nawspnnsyv panvtcdddi nlvreasgls dnetewlkkr 61 daytkealhs flnratsnfs dtsllstlfg snssnmpkia vacsgggyra mlsgagmlaa 121 mdnrtdgane hglggllqga tylaglsggn wltstlawnn wtsvqaivdn ttesnsiwdi 181 shsiltpdgi nifktgsrwd disddvqdkk dagfnislad vwgralaynf wpslhrggvg 241 ytwstlread vfkngempfp itvadgrypg ttvinlnatl fefnpfemgs wdptlnaftd 301 vkylgtnvtn gkpvnkgqci agfdntgfit atsstlfnqf llrlnstdlp sfianlatdf 361 ledlsdnsdd iaiyapnpfk eanflqknat ssiieseylf lvdggednqn iplvpllqke 421 reldvifald nsadtddywp dgaslvntyq rqfgsqglnl sfpyvpdvnt fvnlglnkkp 481 tffgcdarnl tdleyippli vyipnsrhsf ngnqstfkms ysdserlgmi kngfeaatmg 541 nftddsdflg cvgcaiirrk qqnlnatlps ecsqcftnyc wngtidsrsv sgvgnddyss 601 saslsasaaa asasasasas asasasgsst hkknagnalv nysnlntntf igvlsvisav 661 fgli // LOCUS NP_001381969 155 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR008C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381969 VERSION NP_001381969.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395039.1 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54810. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..155 /product="uncharacterized protein" /calculated_mol_wt="17234" CDS 1..155 /locus_tag="YMR008C-A" /coded_by="NM_001395039.1:1..468" /note="Novel ORF identified via pan-genome analysis; conserved in other strains of S. cerevisiae" /db_xref="GeneID:65052913" /db_xref="SGD:S000303813" ORIGIN 1 mydlleqkff vreikfasay ylrtgkalnn sktpifqrkh slpawlssav iitapvsndg 61 shsilfarkt lrmimpmfsp lfnrspddcp shltathifq qfsamldygq stkeatnkrr 121 likgsdllva ldrncipsap fvpeialrks gavgs // LOCUS NP_013722 179 aa linear PLN 30-JUN-2025 DEFINITION acireductone dioxygenase (Ni2+-requiring) [Saccharomyces cerevisiae S288C]. ACCESSION NP_013722 VERSION NP_013722.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182505.1 REFERENCE 1 (residues 1 to 179) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 179) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 179) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 179) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09907. Method: conceptual translation. FEATURES Location/Qualifiers source 1..179 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..179 /product="acireductone dioxygenase (Ni2+-requiring)" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /calculated_mol_wt="20748" Region 3..156 /region_name="ARD" /note="ARD/ARD' family; pfam03079" /db_xref="CDD:281122" Site order(81,85,87,91,93,132) /site_type="active" /db_xref="CDD:380360" CDS 1..179 /gene="ADI1" /locus_tag="YMR009W" /coded_by="NM_001182505.1:1..540" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:15938715]" /experiment="EXISTENCE:mutant phenotype:GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity [PMID:15938715]" /experiment="EXISTENCE:mutant phenotype:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:15938715|PMID:18625006]" /note="Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; human ortholog ADI1 can complement yeast adi1 mutant" /db_xref="GeneID:855021" /db_xref="SGD:S000004611" ORIGIN 1 mvkvyihdnk vdsdyraphn sgtelsldel aklgviykyc aneeevneia rqreyknrdv 61 vnicegsfks eaefneklat fyqehlhede eiryclegag yfdvrdastp enwirclves 121 gdllilppgi yhrftlttsn hikalrlfkd epkwqainrs nqadslpvrk dyialinqy // LOCUS NP_013723 405 aa linear PLN 30-JUN-2025 DEFINITION Any1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013723 VERSION NP_013723.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182506.1 REFERENCE 1 (residues 1 to 405) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 405) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 405) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 405) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09908. Method: conceptual translation. FEATURES Location/Qualifiers source 1..405 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..405 /product="Any1p" /calculated_mol_wt="46741" Region 252..311 /region_name="PQ-loop" /note="PQ loop repeat; pfam04193" /db_xref="CDD:461220" CDS 1..405 /gene="ANY1" /locus_tag="YMR010W" /gene_synonym="CFS1" /coded_by="NM_001182506.1:1..1218" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:40047640]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:28057802]" /experiment="EXISTENCE:direct assay:GO:0017128 phospholipid scramblase activity [PMID:40047640]" /experiment="EXISTENCE:direct assay:GO:0032588 trans-Golgi network membrane [PMID:28057802]" /experiment="EXISTENCE:direct assay:GO:0045332 phospholipid translocation [PMID:40047640]" /experiment="EXISTENCE:genetic interaction:GO:0036258 multivesicular body assembly [PMID:40047640]" /experiment="EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:28057802]" /experiment="EXISTENCE:genetic interaction:GO:0045332 phospholipid translocation [PMID:28057802]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:28057802]" /note="Phospholipid scramblase involved in endosome biogenesis; functions with Vps13p, a lipid transfer protein, the biogenesis of multivesicular bodies (MVBs); functions antagonistically to flippases, with the null suppressing growth and membrane trafficking defects of flippase null alleles; PQ loop family member; cycles between early endosomes and the trans-Golgi network; non-essential gene; orthogous to human SLC66A2" /db_xref="GeneID:855022" /db_xref="SGD:S000004612" ORIGIN 1 msttgpldat lirdvavata tkasydmsdt lysylpkvdq fyipewltmq fiannlisft 61 plfsygttii siekcktalg fsidicatml iasilrisyy litpyeitll rqslvmifiq 121 lillrtslky rpdeykyqnl tdveslshli hdiwfeffsc inrpkflsed wknlikslsf 181 tnllkfsfki flaffykilk ffdpnfkrig afwqwdddkn fwrflalfat vqilvtffis 241 nilnwdslaq glgsiigslg llvesllplp qiailyklks vqgfklillv swlcgdtlki 301 tylifgakni salfvifalf qmsldfyigg qyiyyryyyp klrhqhhpnd snspsdedes 361 emyeldlfnt lqkdvekalk qdsndtsdsp qddqvgksqa qavtl // LOCUS NP_013724 541 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013724 VERSION NP_013724.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182507.1 REFERENCE 1 (residues 1 to 541) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 541) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 541) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 541) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09909. Method: conceptual translation. FEATURES Location/Qualifiers source 1..541 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..541 /product="hexose transporter HXT2" /calculated_mol_wt="59710" Region 59..519 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(70,74,200,203..204,207,326..327,331..332,335..336, 361,431..432,435..436,440,463..464,467) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..541 /gene="HXT2" /locus_tag="YMR011W" /coded_by="NM_001182507.1:1..1626" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10191260|PMID:24124599|PMID:17507646]" /experiment="EXISTENCE:direct assay:GO:0055056 D-glucose transmembrane transporter activity [PMID:12702270]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015146 pentose transmembrane transporter activity [PMID:17180689]" /experiment="EXISTENCE:mutant phenotype:GO:1904659 D-glucose transmembrane transport [PMID:2233722]" /note="High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose" /db_xref="GeneID:855023" /db_xref="SGD:S000004613" ORIGIN 1 msefatsrve sgsqqtsihs tpivqkletd espiqtksey tnaelpakpi aaywtviclc 61 lmiafggfvf gwdtgtisgf vnqtdfkrrf gqmksdgtyy lsdvrtgliv gifnigcafg 121 gltlgrlgdm ygrriglmcv vlvyivgivi qiassdkwyq yfigriisgm gvggiavlsp 181 tlisetapkh irgtcvsfyq lmitlgiflg yctnygtkdy snsvqwrvpl glnfafaifm 241 iagmlmvpes prflvekgry edakrslaks nkvtiedpsi vaemdtiman veterlagna 301 swgelfsnkg ailprvimgi miqslqqltg nnyffyygtt ifnavgmkds fqtsivlgiv 361 nfastfvaly tvdkfgrrkc llggsasmai cfvifstvgv tslypngkdq psskaagnvm 421 ivftclfiff faiswapiay vivaesyplr vknramaiav ganwiwgfli gfftpfitsa 481 igfsygyvfm gclvfsffyv fffvcetkgl tleevnemyv egvkpwksgs wiskekrvse 541 e // LOCUS NP_013725 1277 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor 3 subunit CLU1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013725 VERSION NP_013725.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182508.1 REFERENCE 1 (residues 1 to 1277) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1277) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1277) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1277) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09910. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1277 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1277 /product="translation initiation factor 3 subunit CLU1" /calculated_mol_wt="145035" Region 49..124 /region_name="CLU_N" /note="Mitochondrial function, CLU-N-term; pfam15044" /db_xref="CDD:464466" Region 360..595 /region_name="CLU" /note="Clustered mitochondria; pfam13236" /db_xref="CDD:463814" Region 690..931 /region_name="CLU-central" /note="An uncharacterized central domain of CLU mitochondrial proteins; cd15466" /db_xref="CDD:271318" Region 1015..>1169 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" CDS 1..1277 /gene="CLU1" /locus_tag="YMR012W" /gene_synonym="TIF31" /coded_by="NM_001182508.1:1..3834" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:7798228]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /note="Subunit of the eukaryotic translation initiation factor 3 (eIF3); component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation; can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant; eIF3 is also involved in programmed stop codon readthrough" /db_xref="GeneID:855025" /db_xref="SGD:S000004614" ORIGIN 1 msekkeevkn atvkvtvklp kednhshntk hlkktqsskn ndisfeigke skiqtvldvl 61 amipsskylt nvglktiegd sqlsdemsik eivgekselk lqlilkpysa realkhvitv 121 rdfigfaqet sdglsefais tgssfsslpl gpikerskqe ekdeksdpee kkntfkdvtd 181 eeklkfnemv hevfssfkns sinklltses niitpcvrsl sfapynpvpp fyrskghlfy 241 lqivtleges fyitaipsgf yvnksnstkf dpspkentde nahssliyys lfdliasrsk 301 kfishvqafe kklsaldsts yvrpsntflh kpwfvsslpp nnpdylrlqt aaldttpern 361 fndefqaikd lttstlqdri emerlfskvv hefsvtaasg amsifysdfv amnpesptrd 421 qiflkdnify syvsdvsgny egkggdeaai aasnqdlkti nilnrlhmhe vryllttvve 481 fagrrilaqt pvpgllatmg nkivkdantg eevtedfvnd invkygldeg lgkivydadf 541 dsvlekkfvk afhlkkhkvn gtelafssqs kgivgfdkrr yildlantyp ldinfarqnf 601 dnieetgnry phrqtllrpe lvekwwnnkv ekegvefeka yeenlfsynp dayqvegied 661 anvdemsnyl qkevipsviq dylsgnlstp yngehladtl hknginmryl gkiielsqke 721 ldsqivhyeq nlkaveqdnk eyedweksyl qkienmiker qakinklvqe gkevpkelte 781 dlklndeeik kptdgkpvvv aydelvplik iseleivsrs lkhvlkdlsk dvpvflvpsl 841 vayvfnmlvg inynadpkpe pvdefypvnk csfakltrse lleavskqaf lrfrhqlpsn 901 wieaymenpf tlirsvsykf giqllnkeyf ftreqlesyk qsldkkirnk fveppttfsl 961 sdltiiprvk fseytssvse efwaqgasmi nedkqsaltl laqsitvled vnnilhpava 1021 ekylslsaiy nklalypeai afcrkactiy ervsgidsfe mmraltnlai lefsnespyn 1081 atvvynrlae ilkvyelpki hhpaptsifn hleqlalgvq dtklaievlg qlssyvvele 1141 gkdslaygyt esrlgnlfaa lkdfhraleh itvtqgiftk qlgmnhthsa qsrqwvngls 1201 slimdlkqkk qlaqdqmstt gsnsaghkkt nhrqkkddvk pelanksvde lltfiegdss 1261 nsksknktnn kkkhgkk // LOCUS NP_013726 519 aa linear PLN 30-JUN-2025 DEFINITION dolichol kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013726 VERSION NP_013726.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182509.1 REFERENCE 1 (residues 1 to 519) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 519) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 519) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 519) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09911. Method: conceptual translation. FEATURES Location/Qualifiers source 1..519 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..519 /product="dolichol kinase" /EC_number="2.7.1.108" /calculated_mol_wt="58775" Region 322..>470 /region_name="SEC59" /note="Dolichol kinase [Posttranslational modification, protein turnover, chaperones, Cell wall/membrane/envelope biogenesis]; COG0170" /db_xref="CDD:439940" CDS 1..519 /gene="SEC59" /locus_tag="YMR013C" /coded_by="NM_001182509.1:1..1560" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:2657387]" /experiment="EXISTENCE:genetic interaction:GO:0004168 dolichol kinase activity [PMID:12213788]" /experiment="EXISTENCE:genetic interaction:GO:0043048 dolichyl monophosphate biosynthetic process [PMID:12213788]" /experiment="EXISTENCE:mutant phenotype:GO:0004168 dolichol kinase activity [PMID:2657387|PMID:12213788]" /experiment="EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:2657387]" /experiment="EXISTENCE:mutant phenotype:GO:0043048 dolichyl monophosphate biosynthetic process [PMID:1323123|PMID:12213788]" /note="Dolichol kinase; catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation" /db_xref="GeneID:855026" /db_xref="SGD:S000004615" ORIGIN 1 mvaiiphasf ttikltqkte gsqmpteeic kinmrtrkfd vggnsrdfec fysnfvqtvi 61 llgtffycve rlqpwsivta disykqifvn vfvvclimvg liftkywqhg ykslpkfdti 121 yslylpfmvs llfdtsstvi ntililsvln syrwrtqlvv iilqlcliff nfeagdrlkn 181 iisivinsll slilkyigql ksldnidsnl fsilltnily vseagtvhfr ilkgiilalt 241 tiisinyvlk kvmhfkpfml sisfaiglpl fantfihled genpllwlvk yilestirqk 301 ilfawssili lsipsiliek dslslntsrk lwhfiiflli ipsfqmdsnf vkialsgtip 361 vflsieyirf qnlpplgsai elqlrrfadd rdhsgpliis ylyllfgist pllmnnspmg 421 liglgigdsl asiigkrygr irwkgtqktl egtlafivts fivclvllrf dkaaifnhlt 481 tlqlltlctl sgvlegnsvl ndnilipafm miceklitl // LOCUS NP_013727 519 aa linear PLN 30-JUN-2025 DEFINITION Bud22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013727 VERSION NP_013727.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182510.1 REFERENCE 1 (residues 1 to 519) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 519) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 519) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 519) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09912. Method: conceptual translation. FEATURES Location/Qualifiers source 1..519 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..519 /product="Bud22p" /calculated_mol_wt="59923" Region 84..519 /region_name="BUD22" /note="pfam09073" /db_xref="CDD:401132" CDS 1..519 /gene="BUD22" /locus_tag="YMR014W" /coded_by="NM_001182510.1:1..1560" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11452010]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:19806183]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:20498295]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:20498295|PMID:19806183]" /note="Protein required for rRNA maturation and ribosomal subunit biogenesis; required for 18S rRNA maturation; also required for small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern" /db_xref="GeneID:855028" /db_xref="SGD:S000004616" ORIGIN 1 mpsessvsiy kldqleyqyh yltkslqkfe prypktakly ncigkknkkk iekllnslel 61 ktldkeldes yskllnnkih yyethlskci keqiqkiskk nsskvkdaqk nkspsidiek 121 mlatqlsldd lalfmtrfrl ikilhqrikq kskkiegdtn nktwlnnndy sgyindktsk 181 wnpsniwnev itklpscekl naligqskiv qnltesfdls iclifgfdvs amkakkygar 241 ektananqth snidydtddg neknaidsks naigaqtqsn kettsdnedl likeyegmlg 301 ssgdegeggg ylnpninyne vtdeepseas sdeddsderf sdseeneprr kkpklhnlpe 361 lmagyysgnd teeesdednk nvkgkkkkrd taedrtareq msnepkrknr rgqrarrkiw 421 ekkygsqakh vqrelekeme drkqrqieye arvakreaka asleasrsre redrrtetnn 481 kkekesastg eehpswiakr laeeklqkak fegkkikfd // LOCUS NP_013728 538 aa linear PLN 30-JUN-2025 DEFINITION C-22 sterol desaturase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013728 VERSION NP_013728.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182511.1 REFERENCE 1 (residues 1 to 538) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 538) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 538) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 538) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 538) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09913. Method: conceptual translation. FEATURES Location/Qualifiers source 1..538 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..538 /product="C-22 sterol desaturase" /EC_number="1.14.19.41" /calculated_mol_wt="61204" Region 103..522 /region_name="CYP61_CYP710" /note="C-22 sterol desaturase subfamily, such as fungal cytochrome P450 61 and plant cytochrome P450 710; cd11082" /db_xref="CDD:410703" Site order(159,163,170,215,332..333,336..337,340..341,344,397, 406,408,432,468..470,474..478,481..482) /site_type="other" /note="heme binding site [chemical binding]" /db_xref="CDD:410703" Site order(246..247,332,335..336,340,404..407) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:410703" CDS 1..538 /gene="ERG5" /locus_tag="YMR015C" /gene_synonym="CYP61" /coded_by="NM_001182511.1:1..1617" /experiment="EXISTENCE:direct assay:GO:0000249 C-22 sterol desaturase (NADPH) activity [PMID:8543054]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:8543054]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:8635732]" /note="C-22 sterol desaturase; a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs" /db_xref="GeneID:855029" /db_xref="SGD:S000004617" ORIGIN 1 mssvaeniiq hathnstlhq lakdqpsvgv ttafsildtl ksmsylkifa tlicillvwd 61 qvayqikkgs iagpkfkfwp iigpflesld pkfeeykakw asgplscvsi fhkfvviast 121 rdlarkilqs skfvkpcvvd vavkilrpcn wvfldgkaht dyrkslnglf tkqalaqylp 181 sleqimdkym dkfvrlsken nyepqvffhe mreilcalsl nsfcgnyite dqvrkiaddy 241 ylvtaalelv nfpiiipytk twygkktadm amkifencaq makdhiaagg kpvcvmdawc 301 klmhdaknsn dddsriyhre ftnkeiseav ftflfasqda ssslacwlfq ivadrpdvla 361 kireeqlavr nndmstelnl dliekmkytn mviketlryr ppvlmvpyvv kknfpvspny 421 tapkgamlip tlypalhdpe vyenpdefip erwvegskas eakknwlvfg cgphvclgqt 481 yvmitfaall gkfalytdfh htvtplseki kvfatifpkd dllltfkkrd pitgevfe // LOCUS NP_013729 785 aa linear PLN 30-JUN-2025 DEFINITION Sok2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013729 VERSION NP_013729.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182512.1 REFERENCE 1 (residues 1 to 785) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 785) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 785) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 785) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09914. Method: conceptual translation. FEATURES Location/Qualifiers source 1..785 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..785 /product="Sok2p" /calculated_mol_wt="85512" Region 433..509 /region_name="KilA-N" /note="KilA-N domain; pfam04383" /db_xref="CDD:367917" CDS 1..785 /gene="SOK2" /locus_tag="YMR016C" /coded_by="NM_001182512.1:1..2358" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:11046133|PMID:8524252]" /note="Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; relocalizes to the cytosol in response to hypoxia; SOK2 has a paralog, PHD1, that arose from the whole genome duplication" /db_xref="GeneID:855030" /db_xref="SGD:S000004618" ORIGIN 1 mpignpintn diksnrmrqe snmsavsnse stigqstqqq qqqqqylgqs vqplmpvsyq 61 yvvpeqwpyp qyyqqpqsqs qqqlqsqpqm yqvqesfqss gsdsnasnpp stsvgvpsna 121 tatalpngsa ittkksnnst nisnnvpyyy yfpqmqaqqs maysypqayy yypangdgtt 181 ngatpsvtsn qvqnpnlekt ystfeqqqqh qqqqqlqaqt ypaqppkign afskfsksgp 241 psdsssgsms pnsnrtsrns nsisslaqqp pmsnypqpst yqypgfhkts sipnshspip 301 prslttptqg ptsqngplsy nlpqvgllpp qqqqqvsply dgnsitppvk pstdqetylt 361 anrhgvsdqq ydsmaktmns fqtttirhpm pliattnatg sntsgtsasi irprvtttmw 421 edektlcyqv eangisvvrr adndmvngtk llnvtkmtrg rrdgilkaek irhvvkigsm 481 hlkgvwipfe ralaiaqrek iadylyplfi rdiqsvlkqn npsndsssss sstgiksisp 541 rtyyqpinny qnpngpsnis aaqltyssmn lnnkiipnns ipavstiaag ekplkkctmp 601 nsnqleghti tnlqtlsatm pmkqqlmgni asplsyprna tmnsastlgi tpadskpltp 661 sptttntnqs sesnvgsiht gitlprvese sashskwske adsgntvpdn qtlkeprssq 721 lpisaltstd tdkiktstsd eatqpnepse aepvkesess ksqvdgagdv sneeiaaddt 781 kkqek // LOCUS NP_013730 397 aa linear PLN 30-JUN-2025 DEFINITION Spo20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013730 VERSION NP_013730.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182513.1 REFERENCE 1 (residues 1 to 397) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 397) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 397) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 397) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09915. Method: conceptual translation. FEATURES Location/Qualifiers source 1..397 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..397 /product="Spo20p" /calculated_mol_wt="46491" Region 176..245 /region_name="SNARE_SEC9N" /note="N-terminal SNARE motif of SEC9; cd15886" /db_xref="CDD:277239" Site order(178,181..186,188..193,195..196,199..200,202..207, 209..210,212..214,216..221,223..224,226..228,230..231, 233..235,237..238,240..242,244..245) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277239" Site 213 /site_type="active" /note="zero layer [active]" /db_xref="CDD:277239" Region 327..392 /region_name="t_SNARE" /note="Helical region found in SNAREs; smart00397" /db_xref="CDD:197699" Site order(361,368,371) /site_type="other" /note="flanking leucine-zipper layers" /db_xref="CDD:277192" Site 364 /site_type="active" /note="zero layer [active]" /db_xref="CDD:277192" CDS 1..397 /gene="SPO20" /locus_tag="YMR017W" /gene_synonym="DBI9" /coded_by="NM_001182513.1:1..1194" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:14742704]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:14742704]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14742704]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:14742704]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:10924463]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:14742704|PMID:27480805]" /experiment="EXISTENCE:mutant phenotype:GO:0005628 prospore membrane [PMID:9425151]" /experiment="EXISTENCE:mutant phenotype:GO:0031321 ascospore-type prospore assembly [PMID:9425151]" /experiment="EXISTENCE:physical interaction:GO:0005484 SNAP receptor activity [PMID:10924463]" /note="Meiosis-specific subunit of the t-SNARE complex; required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; binds to phosphatidic acid; SNAP-25 homolog" /db_xref="GeneID:855031" /db_xref="SGD:S000004619" ORIGIN 1 mgfrkilask shhsrhhnqh hknlklqnhr yvlisnitgs hetkylspfr mdncsgsrrr 61 drlhvklksl rnkihkqlhp ncrfddatkt sddkcvsyev perdglatis leevfpksnr 121 cqipeenlge tdsvihrdlg nfanendypq wrkvesqynl envqpeedei vdrlrseirs 181 tklksvktts rtlekaiear ctgkrvlqql scqsnqltki esncdmlkiq snvadrkide 241 lahenrslla lkspnpfrkk rerekrdqiy nlklkhrhlq qetmkraqds dknlainlss 301 eygrygqgve rqrilrdaqk yqfeadeedn qmeidlygnl eqikavsgdl kimahafgre 361 feaqntrmfd iennvqqadn alqakryrle kvigkrw // LOCUS NP_013731 514 aa linear PLN 30-JUN-2025 DEFINITION Pex9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013731 VERSION NP_013731.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182514.1 REFERENCE 1 (residues 1 to 514) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 514) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 514) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 514) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 514) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09916. Method: conceptual translation. FEATURES Location/Qualifiers source 1..514 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..514 /product="Pex9p" /calculated_mol_wt="58934" Region 189..455 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Site order(222..223,226..227,229,254,257..258,261..262,264..265, 288,291..292,295..296,299) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 222..247 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 252..282 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 287..314 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 360..388 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(361,364..365,368..369,371,395,398..399,402..403, 405..406,429,432..433,436..437,440) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 393..423 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 428..455 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..514 /gene="PEX9" /locus_tag="YMR018W" /coded_by="NM_001182514.1:1..1545" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27663510]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:27678487]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:27678487]" /experiment="EXISTENCE:genetic interaction:GO:0016558 protein import into peroxisome matrix [PMID:27678487|PMID:27663510]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:27663510]" /experiment="EXISTENCE:physical interaction:GO:0016558 protein import into peroxisome matrix [PMID:27678487]" /note="Peroxisomal membrane signal receptor for peroxisomal matrix proteins; oleate-inducible condition-specific import receptor for a subset of PTS1-containing matrix proteins; localizes to both the cytosol and the peroxisomal membrane; similar to human PEX5Rp, a peroxin protein 5 related protein; paralog of Pex5p" /db_xref="GeneID:855032" /db_xref="SGD:S000004620" ORIGIN 1 mnevtcsitg dnpihkinng lglkwnnlgk fsdfqtndsa ardartidyi ftncqtgssi 61 gkidfraalp adksqhsgvs ekefsrlenq wskefscfpk nknadvtkps rnkhekrsan 121 lhnryfaqyy stayqqnriy pcrisynehs svsngwefqf ksienqllne lkiennveek 181 tvgyeyvaey eetidfmhml ssvpqtyqfl ksniyiterd pykigcvlmd ngsnlnevvm 241 afeaaisqdp shinawlklg ivnfeneses ngelalrncl nldpnntial enlaihhinq 301 qneseslklf hkwilskfsk vfqpsagenk dsinkipkka hlahilesll nmgiekkdqy 361 diysvlsily ysdqkikqsq kcleflllek pnngtiwnry gailantksy hsainaynkc 421 kqlrpnftrv rynlaiaymn kgdyvkaskm lievillrsk gyehnkakmq nkfmqnlkna 481 liasknfdsl dlingshnte slistlkaiy nkmd // LOCUS NP_013732 949 aa linear PLN 30-JUN-2025 DEFINITION Stb4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013732 VERSION NP_013732.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182515.1 REFERENCE 1 (residues 1 to 949) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 949) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 949) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 949) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 949) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 949) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 949) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09917. Method: conceptual translation. FEATURES Location/Qualifiers source 1..949 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..949 /product="Stb4p" /calculated_mol_wt="109694" Region 82..122 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(82,86,91..94,96,99,108) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(87,90,97,103,106,113) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 401..661 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..949 /gene="STB4" /locus_tag="YMR019W" /coded_by="NM_001182515.1:1..2850" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay" /db_xref="GeneID:855033" /db_xref="SGD:S000004621" ORIGIN 1 msinheiyyi lvfehrsvai kliivvivll qfflarsrqi drtwahtnrk erfremtaig 61 ntddaldtst aaskengkgr lrvqkacelc kkrkvkcdgn npclncskhq kecrydfkat 121 nrkrrrrqva savrdvskty aetsesfprd llsksniiin apsdgvsssa snspnpnshy 181 hhisstlpfm sgrpnhtfhs gsnlngennn nsfpedhmak lllqlssklg nttkessirt 241 trtnasdvna nptvvnmkns qedcdtnhrs aicdsaealh nnninskenk iinsqitntv 301 ndhfespwqt fsldkyrfhr ryqnilpyyl gvsilkdlsp qtieyaklkr prvqnygwnl 361 sgghylkykg dfrsqeknir heskffdfdd pvhlslinkl lryyfdeinp vfsiiheatf 421 wqqynnkflr qgkqnnssan lftsmlylil sttlrfregh ldgqkgqgty sntslnitfe 481 eksilikkps ieenlfkyay liintltfew esfeliqswl litfyfrtcy rqtacwnals 541 qavnmcngms lylnkfpeih stydeskawh cfwccfimdk lisfqmgrfy qlslpasemc 601 eqmnlvkskk flqeeddwfh eetfqmldls iivtqflkrd aqdlnlnetv qlrsqlgqwy 661 dtfivgsqtn ayddnyryfy qvqpfmtyld irltfevrql fcliapssta nnksleyvvd 721 tellishcqm aienlaeitr snlffvpwwl nlsqlftvnl iciiylhagi avtqnkaimq 781 scqeiwrtle cskpknrpsm lpeclwclkm lnhmfcirlr dsalqleatl gtdhgddtpn 841 rnkfeqfkkv gdndadvevd agereenade rqenphnnsk rvplatrshn ttnfdgsiai 901 spesavanlg tdtglpsdvl dtvskignsp nvfdddlfsn llwfdqnfa // LOCUS NP_013733 508 aa linear PLN 30-JUN-2025 DEFINITION polyamine oxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013733 VERSION NP_013733.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182516.1 REFERENCE 1 (residues 1 to 508) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 508) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 508) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 508) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09918. Method: conceptual translation. FEATURES Location/Qualifiers source 1..508 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..508 /product="polyamine oxidase" /EC_number="1.5.3.17" /calculated_mol_wt="57675" Region 18..503 /region_name="Amino_oxidase" /note="Flavin containing amine oxidoreductase; pfam01593" /db_xref="CDD:396255" CDS 1..508 /gene="FMS1" /locus_tag="YMR020W" /coded_by="NM_001182516.1:1..1527" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0046592 polyamine oxidase activity [PMID:21067138]" /experiment="EXISTENCE:genetic interaction:GO:0046208 spermine catabolic process [PMID:12586697]" /experiment="EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]" /experiment="EXISTENCE:mutant phenotype:GO:0046208 spermine catabolic process [PMID:12586697]" /experiment="EXISTENCE:mutant phenotype:GO:0046592 polyamine oxidase activity [PMID:11154694]" /note="Polyamine oxidase; converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis" /db_xref="GeneID:855034" /db_xref="SGD:S000004622" ORIGIN 1 mntvspakkk viiigagiag lkaastlhqn giqdclvlea rdrvggrlqt vtgyqgrkyd 61 igaswhhdtl tnplfleeaq lslndgrtrf vfdddnfiyi deergrvdhd kellleivdn 121 emskfaelef hqhlgvsdcs ffqlvmkyll qrrqfltndq irylpqlcry lelwhgldwk 181 llsakdtyfg hqgrnafaln ydsvvqriaq sfpqnwlkls cevksitrep sknvtvnced 241 gtvynadyvi itvpqsvlnl svqpeknlrg riefqpplkp viqdafdkih fgalgkvife 301 feeccwsnes skivtlanst nefveivrna enldeldsml eredsqkhts vtcwsqplff 361 vnlskstgva sfmmlmqapl tnhiesired kerlfsffqp vlnkimkcld sedvidgmrp 421 ienianankp vlrniivsnw trdpysrgay sacfpgddpv dmvvamsngq dsrirfageh 481 timdgagcay gawesgrrea trisdllk // LOCUS NP_013734 417 aa linear PLN 30-JUN-2025 DEFINITION Mac1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013734 VERSION NP_013734.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182517.1 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09919. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..417 /product="Mac1p" /calculated_mol_wt="46386" Region 2..40 /region_name="Cu_FIST" /note="Copper-Fist; smart00412" /db_xref="CDD:128690" CDS 1..417 /gene="MAC1" /locus_tag="YMR021C" /gene_synonym="CUA1" /coded_by="NM_001182517.1:1..1254" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:9867833]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8262047]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9159110]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10887177]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:9211922|PMID:8262047]" /experiment="EXISTENCE:mutant phenotype:GO:0045732 positive regulation of protein catabolic process [PMID:12011036]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8262047]" /note="Copper-sensing transcription factor; involved in regulation of genes required for high affinity copper transport; required for regulation of yeast copper genes in response to DNA-damaging agents; undergoes changes in redox state in response to changing levels of copper or MMS" /db_xref="GeneID:855035" /db_xref="SGD:S000004623" ORIGIN 1 miifngnkya cascirghrs stcrhshrml ikvrtrgrps pmairdailv dstsqsteye 61 ngaqiegdcc samnqqpilf vrasavrkar mingklhilm eegftahepk distftddgn 121 kyiteteflr khspkapatg tispdstkss sssekkersr lqqepirhfs ncckkdksqn 181 pasngktnka psddiftpyg slestsafnd ilqenynssv pgahdssetl tpqstttiaa 241 phssdvaskv evlthkgifl stqcscedes cpcvnclihr seeelnsyiq qsgvpltnig 301 eaqitdkmmd ylddckctdk ecicppdnct cdgcfshstn iipfekfffy gilnarltrk 361 tqikfkgklv pskywwdflk lqvplmtdaq lelldihawf qklvsnyaph lsdatts // LOCUS NP_013735 165 aa linear PLN 30-JUN-2025 DEFINITION E2 ubiquitin-conjugating protein UBC7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013735 VERSION NP_013735.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182518.1 REFERENCE 1 (residues 1 to 165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 165) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09920. Method: conceptual translation. FEATURES Location/Qualifiers source 1..165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..165 /product="E2 ubiquitin-conjugating protein UBC7" /EC_number="2.3.2.23" /calculated_mol_wt="18389" Region 7..163 /region_name="UBCc_UBE2G2" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 G2 and related proteins; cd23796" /db_xref="CDD:467416" CDS 1..165 /gene="UBC7" /locus_tag="YMR022W" /gene_synonym="DER2; QRI8" /coded_by="NM_001182518.1:1..498" /experiment="EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873066|PMID:16873065]" /experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873065|PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:9172777]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9388185]" /experiment="EXISTENCE:direct assay:GO:0036503 ERAD pathway [PMID:12105183]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:18971375]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:8641272]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:15643069]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:8641272|PMID:8781238]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]" /note="Ubiquitin conjugating enzyme; involved in the ER-associated protein degradation (ERAD) pathway and in the inner nuclear membrane-associated degradation (INMAD) pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly" /db_xref="GeneID:855036" /db_xref="SGD:S000004624" ORIGIN 1 msktaqkrll kelqqlikds ppgivagpks ennifiwdcl iqgppdtpya dgvfnaklef 61 pkdyplsppk ltftpsilhp niypngevci silhspgddp nmyelaeerw spvqsvekil 121 lsvmsmlsep niesganida cilwrdnrpe ferqvklsil kslgf // LOCUS NP_013736 526 aa linear PLN 30-JUN-2025 DEFINITION Mss1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013736 VERSION NP_013736.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182519.1 REFERENCE 1 (residues 1 to 526) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 526) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 526) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 526) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09921. Method: conceptual translation. FEATURES Location/Qualifiers source 1..526 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..526 /product="Mss1p" /calculated_mol_wt="58221" Region 38..526 /region_name="trmE" /note="tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; PRK05291" /db_xref="CDD:235392" Site 281..288 /site_type="other" /note="G1 box" /db_xref="CDD:206727" Site order(284,286..289,394..395,397,425..427) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206727" Site 296..312 /site_type="other" /note="Switch I region" /db_xref="CDD:206727" Site 309 /site_type="other" /note="G2 box" /db_xref="CDD:206727" Site order(327..334,336..338,340..354) /site_type="other" /note="Switch II region" /db_xref="CDD:206727" Site 328..331 /site_type="other" /note="G3 box" /db_xref="CDD:206727" Site 394..397 /site_type="other" /note="G4 box" /db_xref="CDD:206727" Site 425..427 /site_type="other" /note="G5 box" /db_xref="CDD:206727" CDS 1..526 /gene="MSS1" /locus_tag="YMR023C" /gene_synonym="PET53" /coded_by="NM_001182519.1:1..1581" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11604502]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0070899 mitochondrial tRNA wobble uridine modification [PMID:15509579]" /note="Mitochondrial protein; forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3" /db_xref="GeneID:855037" /db_xref="SGD:S000004625" ORIGIN 1 mnsasflqsr lisrsflvrr slkrysglak pytfqqptiy alstpanqts aiaiirisgt 61 hakyiynrlv dsstvppirk ailrniysps scsvkphdqk eskilldtsl llyfqapysf 121 tgedvlelhv hggkavvnsi lkaigslhdr ssgkdirfal pgdfsrrafq ngkfdltqle 181 gikdlidset esqrrsalss fngdnkilfe nwretiienm aqltaiidfa ddnsqeiqnt 241 deifhnvekn iiclrdqivt fmqkveksti lqngiklvll gapnvgkssl vnsltnddis 301 ivsdipgttr dsidaminvn gykviicdta girekssdki emlgidrakk ksvqsdlclf 361 ivdptdlskl lpedilahls sktfgnkrii ivvnksdlvs ddemtkvlnk lqtrlgskyp 421 ilsvscktke gieslistlt snfeslsqss adaspvivsk rvseilkndv lygleeffks 481 kdfhndivla tenlryasdg iakitgqaig ieeildsvfs kfcigk // LOCUS NP_013737 390 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL44 MRPL3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013737 VERSION NP_013737.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182520.1 REFERENCE 1 (residues 1 to 390) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 390) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 390) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 390) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 390) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 390) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 390) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09922. Method: conceptual translation. FEATURES Location/Qualifiers source 1..390 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..390 /product="mitochondrial 54S ribosomal protein mL44 MRPL3" /calculated_mol_wt="43869" Region 114..288 /region_name="RIBOc" /note="Ribonuclease III family; smart00535" /db_xref="CDD:197778" Region 290..373 /region_name="DSRM_MRPL3_like" /note="double-stranded RNA binding motif of Saccharomyces cerevisiae mitochondrial 54S ribosomal protein L3 (MRPL3) and similar proteins; cd19873" /db_xref="CDD:380702" Site order(290..291,293,296,302,304..305,307..308,312,319..321, 328..329,331..334,336,340,353..356,359,363) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:380702" CDS 1..390 /gene="MRPL3" /locus_tag="YMR024W" /gene_synonym="mL44" /coded_by="NM_001182520.1:1..1173" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit; located in close proximity to the polypeptide exit channel of the ribosome; mutations in human homolog MRPL44 cause childhood cardiomyopathy; human MRPL44 deficiency results in inefficient assembly of the mitochondrial ribosome, and in tissue-specific respiratory chain deficiency, manifesting as either Complex I+Complex IV or Complex IV deficiency, depending on a cell type" /db_xref="GeneID:855039" /db_xref="SGD:S000004626" ORIGIN 1 mgivlkraia agmkpfpnst whwsrtirpf sqhlsstcfl qqssrftskr ylhlstltqq 61 ekrflpesel akykeyyqgl kstvneipes vaskspslrt lhkrlqlpne ltystlsrcl 121 tcpsaklpdk innptkgaaf vntvptnkyl dnhglnimgk nllsyhvtks iiqkyprlpt 181 vvlnaavnay iseavlahia kywgievett svlsrylkme pfeftlgrlk ffnnslnskd 241 gielitgknf setsalamsv rsiiaaiwav teqkdsqavy rfiddhimsr klditkmfqf 301 eqptrelaml crreglekpv sklvaesgrl skspvfivhv fsgeetlgeg ygsslkeaka 361 raatdalmkw ycyeplaqqe pvidpgtvvv // LOCUS NP_013738 295 aa linear PLN 30-JUN-2025 DEFINITION Csi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013738 VERSION NP_013738.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182521.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09923. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..295 /product="Csi1p" /calculated_mol_wt="34389" CDS 1..295 /gene="CSI1" /locus_tag="YMR025W" /coded_by="NM_001182521.1:1..888" /experiment="EXISTENCE:direct assay:GO:0008180 COP9 signalosome [PMID:12446563]" /experiment="EXISTENCE:mutant phenotype:GO:0000338 protein deneddylation [PMID:12446563|PMID:12186635]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:12446563]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:12446563]" /note="Subunit of the Cop9 signalosome; which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling; functional equivalent of canonical Csn6 subunit of the COP9 signalosome" /db_xref="GeneID:855040" /db_xref="SGD:S000004627" ORIGIN 1 mdllkfssla iseinflhes sfdsidhswf lligckldqd deiyipingn eaesqwyiek 61 viripmqend kinqerlerr inltkvtqkd icilgildlc qleedenitn kvtekvltql 121 talalkylik ynvfrqhtsf qeavnslkgy kiensvqiga eiildflqdk vqikdvndry 181 qiptpnntvd pgfdefqlid mkdkeiniqk ynnntirkll ekinrmiifl knydatdkpf 241 sstqdvilrk ismlvtqlqr ggtsdmnyll dnkineikll eisckqweis nmlkk // LOCUS NP_013739 399 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein ligase peroxin 12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013739 VERSION NP_013739.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182522.1 REFERENCE 1 (residues 1 to 399) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 399) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 399) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 399) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 399) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09924. Method: conceptual translation. FEATURES Location/Qualifiers source 1..399 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..399 /product="ubiquitin-protein ligase peroxin 12" /calculated_mol_wt="45861" Region 41..295 /region_name="Pex2_Pex12" /note="Pex2 / Pex12 amino terminal region; pfam04757" /db_xref="CDD:398431" Region 332..385 /region_name="RING_Ubox" /note="RING finger (Really Interesting New Gene) domain and U-box domain superfamily; cl17238" /db_xref="CDD:473075" Site order(334,337,349,351,354,357,369,372) /site_type="other" /note="cross-brace motif" /db_xref="CDD:438111" CDS 1..399 /gene="PEX12" /locus_tag="YMR026C" /gene_synonym="PAS11" /coded_by="NM_001182522.1:1..1200" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:35768507|PMID:11370741]" /experiment="EXISTENCE:direct assay:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:22471590|PMID:19687296]" /experiment="EXISTENCE:direct assay:GO:1902495 transmembrane transporter complex [PMID:35768507]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:35768507|PMID:22375831]" /experiment="EXISTENCE:direct assay:GO:1990757 ubiquitin ligase activator activity [PMID:35768507]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:11370741|PMID:15536088|PMID:9090384]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:12667447]" /note="C3HC4-type RING-finger peroxin and E3 ubiquitin ligase; required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder" /db_xref="GeneID:855041" /db_xref="SGD:S000004628" ORIGIN 1 msfysnlpsa gqssrgssts grngvglepl yptifeimss qeidsllpas iryllanhlv 61 anfpnrytlr lnkyffewfq aikgfvewyh lktynstfid rfyglqlfss rdrnlaltqc 121 lnpkgqsewp qglqlnqqqk sviflekiil pyitakldei lekismnnif ssdetenkwp 181 kraflriypf ikkllalsnl lvkllfltkr tgsvsllqyl fkieyttvrp lsselsglke 241 tkgmdnrlrk tnissifalm qgqlsiiprf ltfmgsqffp tfifvlrvyq wwttqdmttk 301 lqkrvndlde diprppfssh sdktedkegv seacpvcekt vqnpcvletg yvacypcais 361 ylvnneghcp vtnkkllgct ynkhtnkwev vtgirklli // LOCUS NP_013740 470 aa linear PLN 30-JUN-2025 DEFINITION putative methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013740 VERSION NP_013740.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182523.1 REFERENCE 1 (residues 1 to 470) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 470) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 470) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 470) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09925. Method: conceptual translation. FEATURES Location/Qualifiers source 1..470 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..470 /product="putative methyltransferase" /calculated_mol_wt="53998" Region 19..438 /region_name="ARMT1-like_dom" /note="Damage-control phosphatase ARMT1-like domain; pfam01937" /db_xref="CDD:396496" CDS 1..470 /locus_tag="YMR027W" /coded_by="NM_001182523.1:1..1413" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:27322068]" /note="A metal-dependent phosphatase, part of the DUF89 protein family; dephosphorylates fructose-1-phosphate; human ortholog, C6orf211 is involved in response to DNA damage; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene" /db_xref="GeneID:855042" /db_xref="SGD:S000004629" ORIGIN 1 mtipgrfmti dkgtfgeyta strwpiiiqn aiddlskhqe teksngtkfe qgevikkelk 61 efrqeiidrv plrpfteeei kianvplsfn eylkkhpevn wgavewlfse vylyrrvnvl 121 fqrqcewakf difnrlkqst fessfygvve lalryenllp qlremkqnpg neiddilkvl 181 fkefieislw gnatdlsllt natlediksi qgakaraase skivvndtek awevltkara 241 dansreirvd fvldnsgfel yadlmlaafl lqsglatkci fhakdipymv sdvmlkdfdi 301 lvhdlrdref fpsgepstke sraldlfage mekfvssgki efredsfwtt eldywnldan 361 etkyhgsilh kdlqksnlvi fkgdlnyrkl tgdrkwprtt kwetaigpla tngitslslr 421 tckadvqval pegldaklsq ewekenpgrg swwccsgkwa vicfcsgihk // LOCUS NP_013741 366 aa linear PLN 30-JUN-2025 DEFINITION Tap42p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013741 VERSION NP_013741.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182524.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09926. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..366 /product="Tap42p" /calculated_mol_wt="42437" Region 4..355 /region_name="TAP42" /note="TAP42-like family; pfam04177" /db_xref="CDD:461209" CDS 1..366 /gene="TAP42" /locus_tag="YMR028W" /coded_by="NM_001182524.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16874307]" /experiment="EXISTENCE:genetic interaction:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:19684113]" /experiment="EXISTENCE:genetic interaction:GO:1903432 regulation of TORC1 signaling [PMID:14551259|PMID:10329624]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:19684113]" /experiment="EXISTENCE:mutant phenotype:GO:1903432 regulation of TORC1 signaling [PMID:12820961|PMID:10604478]" /note="Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits" /db_xref="GeneID:855043" /db_xref="SGD:S000004630" ORIGIN 1 masvteqfnd iislystkle htslrqdspe yqglllstik kllnlktaif drlalfstne 61 tiddvstasi kflavdyylg llisrrqsnd sdvaqrqsmk liylkksves finfltllqd 121 yklldplvge klgnfkdryn pqlselyaqp knnkdlsgaq lkrkekielf qrnkeistkl 181 hclelelknn dedhdhdell relylmrlhh fsldtinnie qnlfecemls nflknsvhev 241 kssgtqirke sndddstgft dkleninkpl idkkgqvlrn ftlvdkrqql qqkvrgygqy 301 gptmsveefl dkefeegrvl qggeepeqap deenmdwqdr etykarewde fkeshakgsg 361 ntmnrg // LOCUS NP_013742 523 aa linear PLN 30-JUN-2025 DEFINITION Far8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013742 VERSION NP_013742.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182525.1 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09927. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..523 /product="Far8p" /calculated_mol_wt="59170" Region 14..101 /region_name="Striatin" /note="Striatin family; pfam08232" /db_xref="CDD:462401" CDS 1..523 /gene="FAR8" /locus_tag="YMR029C" /coded_by="NM_001182525.1:1..1572" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23625923]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]" /note="Protein involved in recovery from arrest in response to pheromone; acts in a cell cycle arrest recovery pathway independent from Far1p; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p" /db_xref="GeneID:855044" /db_xref="SGD:S000004631" ORIGIN 1 mainqahvhp hytlpgvmhy lqteftkner dritwelers emkariaele genrdlkhql 61 nqiqskavsp egekeekhvp dsllqsklav qenvkeiiyl lkgpntvnql eslnsreags 121 elhdleklnv ntpkeegsak tngmdilnna lldtkpnpkq gpsespsptk vkslfstank 181 rennetiski hselskvdii ssygdcmaly dadtksleih qvdanlnskl lkkislgqds 241 dimkffwvst skllvieksf hlklfsissa slisdvdllq dseqpfsssd iinidfknkw 301 lliasknksq iriweldnie apedvpinik etyeithdnd dddsndstni ldcilgitek 361 slillssnpy qltiydfegk llqkidlkid tilsgkpeee gyhlfldrkt sklliqlsne 421 rllvysfdkk kvvlkeqltp sstlpiqldl ndsiitvsys ngdfefrnle nlkpsidefv 481 vadinfserk epvvfssnli vdstpvlitv nknnevllhk iki // LOCUS NP_013743 376 aa linear PLN 30-JUN-2025 DEFINITION Rsf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013743 VERSION NP_013743.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182526.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09928. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..376 /product="Rsf1p" /calculated_mol_wt="43329" Region 133..348 /region_name="RSF" /note="Respiratory growth transcriptional regulator; pfam14876" /db_xref="CDD:464354" CDS 1..376 /gene="RSF1" /locus_tag="YMR030W" /coded_by="NM_001182526.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12734673]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:12734673]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:12734673]" /experiment="EXISTENCE:mutant phenotype:GO:0006390 mitochondrial transcription [PMID:12734673]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:12734673]" /note="Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes" /db_xref="GeneID:855045" /db_xref="SGD:S000004632" ORIGIN 1 mkdlnpemgk fattkgppqd nrgmvdiatl pnfpanrsgt preemylapn kmetprilnm 61 nmvpdylqke nfspdfssat vsaksspvnv thdeslplgt iesnstkdsk yavqrqqqqv 121 vdfiennmql lssetlnfrs dimktlelpi pkrrdikgnh lskllfaksp ltintycqfy 181 drrtkricnq emiwkdknsr ekhgsrkyqr hlskvhdvql tpnnfteffd hnsplfqecy 241 dyqsrlmrdl lvepdakfke kkkkkkgdvn gnhpetgssl inhqvqqqnv relqskiamn 301 dlieilidln ipfsvldyqp mrnwlikysi istdtlpdev yfktdpgvne lehnssnlnn 361 snsgtphnhn qnqhtn // LOCUS NP_013744 843 aa linear PLN 30-JUN-2025 DEFINITION Eis1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013744 VERSION NP_013744.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182527.1 REFERENCE 1 (residues 1 to 843) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 843) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 843) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 843) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 843) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09929. Method: conceptual translation. FEATURES Location/Qualifiers source 1..843 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..843 /product="Eis1p" /calculated_mol_wt="93214" Region 324..442 /region_name="Eisosome1" /note="Eisosome protein 1; pfam12757" /db_xref="CDD:432763" Region <506..>742 /region_name="Smc" /note="Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; COG1196" /db_xref="CDD:440809" CDS 1..843 /gene="EIS1" /locus_tag="YMR031C" /coded_by="NM_001182527.1:1..2532" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:19269952|PMID:20526336]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0032126 eisosome [PMID:20526336]" /experiment="EXISTENCE:mutant phenotype:GO:0070941 eisosome assembly [PMID:20526336]" /note="Component of the eisosome required for proper eisosome assembly; similar to Uso1p; authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress; EIS1 has a paralog, YKL050C, that arose from the whole genome duplication" /db_xref="GeneID:855047" /db_xref="SGD:S000004633" ORIGIN 1 mslisavedr dihnigktsg ggsrtssits skkslkhgsk slrkpkvyqt tgeplsreal 61 ykaklkygvy qspaqsysig vsdahaasdk aanlahdnqt tveaykrmfi dpnatkaask 121 mgpkvvrnns itsatsktsk esqtkrkske spgaaaskay smtmettsls sqtnsrsysi 181 tsassvlsga sgsfnstvnp kpktlnlekv lvgaekkaes rikerwepek tnfqygvktd 241 ehgnlnqfsf snemmnnima kvdapkaqdl qkvkkvsaek eaksmkfalg aanavkdmhp 301 gedidksial kaqkretyls qltsqqvltl aranvdrqld iieksdmhrk lftnmeynka 361 avavaqsnhq kktefhnkin mggglflspe ditkiasgli spvlgevser aeaqramdee 421 iaerteaynk ssnewetmer siisndakvl tttanrhqte kktsqekika sfdalvarmd 481 tkvaeretll edtkskeief kkqmqqelkd ekarldqdle ewgkkceqdi tearkeqeel 541 lkpyhddlan aeaehktlve erdeinaeis rlqdaivdhk rkisgygndl daqknrnire 601 ddkllelgqt kesleshlnd dviilankak eqaelstkea rlkqlevdsl inerkselna 661 teielkkekl nlleamkdva sargddkide ekvkkligmt seeyltqnks veknvedlpt 721 qlekieegde lkkeeivgae tknsggdgvp vstaakeate tssavqtkep eekisignks 781 sgkedandck saehskeisv sqkagnnksl gvspdsleht fsgfsqgssi eddqdaisnq 841 ekk // LOCUS NP_013746 669 aa linear PLN 30-JUN-2025 DEFINITION formin-binding protein HOF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013746 VERSION NP_013746.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182529.1 REFERENCE 1 (residues 1 to 669) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 669) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 669) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 669) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 669) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09930. Method: conceptual translation. FEATURES Location/Qualifiers source 1..669 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..669 /product="formin-binding protein HOF1" /calculated_mol_wt="76076" Region 8..92 /region_name="FCH" /note="Fes/CIP4 homology domain; smart00055" /db_xref="CDD:214492" Site order(16,19..20,24,26..27,30..31,33..34,44..45,47..48, 51..52,58..59,62,85,88..89,210,213..214,216,218,221..222, 224..225,228..229,232) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153271" Region <110..>233 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 600..663 /region_name="SH3" /note="Src homology 3 domains; smart00326" /db_xref="CDD:214620" Site order(608,610,613,617,636..637,658,660..661) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212690" CDS 1..669 /gene="HOF1" /locus_tag="YMR032W" /gene_synonym="CYK2" /coded_by="NM_001182529.1:1..2010" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:15775961|PMID:24451263|PMID:9864366|PMID:21498574|PM ID:23468521]" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:23468521|PMID:9864366|PMID:21498574|PMID:24451263]" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:25620000]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:23468521|PMID:27385335]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:23468521]" /experiment="EXISTENCE:direct assay:GO:0008092 cytoskeletal protein binding [PMID:18344988|PMID:9774458]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:23468521]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:23468521]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:32579428]" /experiment="EXISTENCE:direct assay:GO:0051017 actin filament bundle assembly [PMID:32579428]" /experiment="EXISTENCE:direct assay:GO:0051126 negative regulation of actin nucleation [PMID:30076201]" /experiment="EXISTENCE:direct assay:GO:0120155 MIH complex [PMID:24895401]" /experiment="EXISTENCE:genetic interaction:GO:0000281 mitotic cytokinesis [PMID:22623719]" /experiment="EXISTENCE:genetic interaction:GO:0072741 protein localization to cell division site [PMID:23469085]" /experiment="EXISTENCE:genetic interaction:GO:0090339 negative regulation of formin-nucleated actin cable assembly [PMID:24719456]" /experiment="EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:23469085]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:9774458]" /experiment="EXISTENCE:mutant phenotype:GO:0031671 primary cell septum biogenesis [PMID:21498574|PMID:29321253]" /experiment="EXISTENCE:mutant phenotype:GO:0090339 negative regulation of formin-nucleated actin cable assembly [PMID:24719456]" /experiment="EXISTENCE:mutant phenotype:GO:1902404 mitotic actomyosin contractile ring contraction [PMID:9864366]" /experiment="EXISTENCE:mutant phenotype:GO:1903471 regulation of mitotic actomyosin contractile ring contraction [PMID:24895401|PMID:21498574|PMID:23468521]" /experiment="EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:23469085]" /experiment="EXISTENCE:physical interaction:GO:0032038 myosin II heavy chain binding [PMID:23468521]" /experiment="EXISTENCE:physical interaction:GO:0044697 HICS complex [PMID:22623719]" /experiment="EXISTENCE:physical interaction:GO:0120155 MIH complex [PMID:24413167|PMID:24895401]" /note="F-BAR protein that regulates actin cytoskeleton organization; binds and bundles actin filaments, linking them to septins; required for cytokinesis, actin cable organization, and secretory vesicle trafficking; regulates actomyosin ring dynamics and septin localization; N-term. half controls cell size and actin cable levels, while the C-term. half controls actin cable organization, inhibiting Bnr1p-mediated actin nucleation; forms axial striations/pillars at the bud neck; phosphorylated by Dbf2p" /db_xref="GeneID:855048" /db_xref="SGD:S000004635" ORIGIN 1 msysyeacfw dpndngvnil lghisqgirs cdsmilffkq rselekdyar rlgaitgkld 61 kdigtnmdyg klnetfnvvl svekaraqsh skqseilfrq iytdtkafaa nlqaryttls 121 gkierlrmdk fnkkkgcevl qkklqdaqir frdlqlnenn migakrvehn krellkwesn 181 sqeykvqldv lkqeykasqk fwihewaqls celqemenar isflqsklqq fatssmetyi 241 leqtkmdmlt nhlnsftaad eistfskeng tgrlkhktsk gdmnssanwa qmssisttsk 301 ktesymdnir klssqlkete nkrklasidk yekplpspev tmatqfrnst pvirnetkvv 361 anptlslrss pvqlqsnvdd svlrqkpdkp rpivgeeqlk pdedsknpde kglmvhkrnq 421 slsspsesss snptdfshik krqsmesmtt svssmansid dsqrfakswn ssnrkrksms 481 hlqvpssass rsddggrtpn sahnlneddy ntrrdtstst ilfkppvavr gtsrghthrq 541 smimqdssnp iedalyemer iqssskpgtk tgnimdergv vrdrgitvtl pivtsegfpv 601 ieyakamypl igneapglan fhkgdyllit eivnkdwykg evydndridr nhriglipyn 661 fiqllhqgl // LOCUS NP_878141 96 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR030W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878141 VERSION NP_878141.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184572.1 REFERENCE 1 (residues 1 to 96) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 96) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 96) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 96) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 96) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09931. Method: conceptual translation. FEATURES Location/Qualifiers source 1..96 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..96 /product="uncharacterized protein" /calculated_mol_wt="11127" CDS 1..96 /locus_tag="YMR030W-A" /coded_by="NM_001184572.1:1..291" /note="hypothetical protein; mCherry fusion protein localizes to the cytosol" /db_xref="GeneID:1466499" /db_xref="SGD:S000028574" ORIGIN 1 myinftsfli kekkynvrfl lsrnrkiyaa vgeghlsgfv tknhkisrls fifskkkkvf 61 ftifdtiiti ivrsgipfpl lcsfgrnkiy ilfnvl // LOCUS NP_013747 467 aa linear PLN 30-JUN-2025 DEFINITION Arp9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013747 VERSION NP_013747.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182530.1 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09932. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..467 /product="Arp9p" /calculated_mol_wt="52943" Region 8..465 /region_name="ASKHA_NBD_ScArp9-like" /note="nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein 9 (Arp9) and similar proteins; cd10208" /db_xref="CDD:466814" CDS 1..467 /gene="ARP9" /locus_tag="YMR033W" /gene_synonym="RSC12; SWP59" /coded_by="NM_001182530.1:1..1404" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11011149]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:8127913|PMID:9726966|PMID:18644858]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:12183366|PMID:10619019]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12183366]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:12183366]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9726966]" /note="Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation" /db_xref="GeneID:855049" /db_xref="SGD:S000004636" ORIGIN 1 mapfrqdsil iiyprsqttl vqfglneetf tvpeleiptq iyrttrqdgs ytyhstnkdn 61 kaelikpiqn geiidisaft qflrlifvsi lsdranknqd afeaelsnip lllithhsws 121 qsdleiitqy vfesleinnl iqlpaslaat ysmislqncc iidvgthhtd iipivdyaql 181 dhlvssipmg gqsindslkk llpqwdddqi eslkkspife vlsddakkls sfdfgnened 241 edegtlnvae iitsgrdtre vleerergqk vknvknsdle fntfwdekgn eikvgkqrfq 301 gcnnliknis nrvgltldni ddinkakavw eniiivggtt sisgfkeall gqllkdhlii 361 epeeekskre eeaksvlpaa tkkkskfmtn stafvptiey vqcptvikla kypdyfpewk 421 ksgyseiifl gaqivskqif thpkdtfyit rekynmkgpa alwdvqf // LOCUS NP_013748 434 aa linear PLN 30-JUN-2025 DEFINITION Rch1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013748 VERSION NP_013748.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182531.1 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09933. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..434 /product="Rch1p" /calculated_mol_wt="48244" Region 23..385 /region_name="SBF_like" /note="SBF-like CPA transporter family (DUF4137); pfam13593" /db_xref="CDD:433336" CDS 1..434 /gene="RCH1" /locus_tag="YMR034C" /coded_by="NM_001182531.1:1..1305" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:26832117]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26832117]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0051481 negative regulation of cytosolic calcium ion concentration [PMID:26832117]" /note="Negative regulator of cytosolic calcium homeostasis; localizes to the plasma membrane, concentrating at the bud neck during cell division; regulated by Crz1p through a CDRE promoter element; non-essential gene; putative transporter with sequence similarity to human SLC10A7; functional homolog of C. albicans RCH1" /db_xref="GeneID:855050" /db_xref="SGD:S000004637" ORIGIN 1 mktqyslirk iwahsvtefl ksqwfficla iliviarfap nfardgglik gqysigygcv 61 awiflqsglg mksrslmanm lnwrahatil vlsflitssi vygfccavka andpkiddwv 121 ligliltatc pttvasnvim ttnaggnsll cvcevfignl lgafitpalv qmftnrapfa 181 ygnpatgngi galygrvmkq vglsvfvplf vgqviqncfp kgtayylgfl kkyhikigsy 241 mlllimfssf stafyqdaft svshvciifl cffnlgiyif ftglsylcar pwfilklfph 301 epiegkstrl yrysynifrp fyyskedaic imfcgpakta algvslitsq ygdkkehlgk 361 llvplvlyqv eqvmtanffv slfkrwiqkd aqadgsessc aneneevdle kiisigtgen 421 qsvlsnnvpy tqpr // LOCUS NP_013749 177 aa linear PLN 30-JUN-2025 DEFINITION endopeptidase catalytic subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_013749 VERSION NP_013749.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182532.1 REFERENCE 1 (residues 1 to 177) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 177) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 177) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 177) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09934. Method: conceptual translation. FEATURES Location/Qualifiers source 1..177 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..177 /product="endopeptidase catalytic subunit" /calculated_mol_wt="19799" Region 34..147 /region_name="S26_SPase_I" /note="The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; cd06530" /db_xref="CDD:119398" Site order(41,91) /site_type="active" /note="Catalytic site [active]" /db_xref="CDD:119398" CDS 1..177 /gene="IMP2" /locus_tag="YMR035W" /coded_by="NM_001182532.1:1..534" /experiment="EXISTENCE:direct assay:GO:0004175 endopeptidase activity [PMID:8132591]" /experiment="EXISTENCE:mutant phenotype:GO:0004175 endopeptidase activity [PMID:8266095]" /experiment="EXISTENCE:mutant phenotype:GO:0006627 protein processing involved in protein targeting to mitochondrion [PMID:8266095]" /experiment="EXISTENCE:physical interaction:GO:0042720 mitochondrial inner membrane peptidase complex [PMID:8132591|PMID:8266095]" /note="Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificity), and Som1p" /db_xref="GeneID:855051" /db_xref="SGD:S000004638" ORIGIN 1 mfragsskrf lrntliaisw vpvlltinnn vvhiaqvkgt smqptlnpqt etlatdwvll 61 wkfgvknpsn lsrddiilfk aptnprkvyc krvkglpfdt idtkfpypkp qvnlprghiw 121 vegdnyfhsi dsntfgpiss glvigkaiti vwppsrwgtd lklstgrdci skraile // LOCUS NP_013750 554 aa linear PLN 30-JUN-2025 DEFINITION putative tyrosine protein phosphatase MIH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013750 VERSION NP_013750.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182533.1 REFERENCE 1 (residues 1 to 554) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 554) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 554) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09935. Method: conceptual translation. FEATURES Location/Qualifiers source 1..554 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..554 /product="putative tyrosine protein phosphatase MIH1" /EC_number="3.1.3.48" /calculated_mol_wt="63227" Region 1..442 /region_name="MIH1" /note="Mitotic inducer, protein phosphatase [Cell division and chromosome partitioning]; COG5105" /db_xref="CDD:227436" CDS 1..554 /gene="MIH1" /locus_tag="YMR036C" /coded_by="NM_001182533.1:1..1665" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:2649252]" /experiment="EXISTENCE:mutant phenotype:GO:0051231 spindle elongation [PMID:30072442]" /note="Protein tyrosine phosphatase; involved in cell cycle control and retrograde protein transport; regulates the phosphorylation state of Cdc28p; modulates phosphorylation of retromer component Vps26p; homolog of S. pombe cdc25" /db_xref="GeneID:855052" /db_xref="SGD:S000004639" ORIGIN 1 mnnifhgted ecanedvlsf qkislkspfg kkknifrnvq tffkskskhs nvdddlinke 61 nlafdkspll tnhrskeidg pspnikqlgh rdeldenene nddivlsmhf asqtlqsptr 121 nssrrsltnn rdndllsrik ypgspqrsss fsrsrslsrk psmnsssnss rrvqrqdgki 181 prssrkssqk fsnitqntln ftsassspla pnsvgvkcfe sclaktqipy yyddrnsndf 241 fprispetlk nilqnnmces fynscriidc rfeyeytggh iinsvnihsr deleyefihk 301 vlhsdtsnnn tlptlliihc efsshrgpsl ashlrncdri inqdhypklf ypdilildgg 361 ykavfdnfpe lcyprqyvgm nsqenllnce qemdkfrres krfatknnsf rklaspsnpn 421 ffyrdshqss ttmassalsf rfepppklsl nhrrvssgss lnssestgde nffpilskss 481 mssnsnlsts hmllmdgldt psyfsfeder gnhqqvsgde eqdgdftfvg sdredlprpa 541 rrslfpslet edkk // LOCUS NP_013751 704 aa linear PLN 30-JUN-2025 DEFINITION stress-responsive transcriptional activator MSN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013751 VERSION NP_013751.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182534.1 REFERENCE 1 (residues 1 to 704) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 704) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 704) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 704) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 704) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09936. Method: conceptual translation. FEATURES Location/Qualifiers source 1..704 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..704 /product="stress-responsive transcriptional activator MSN2" /calculated_mol_wt="77730" Region 127..594 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 647..670 /region_name="zf-C2H2_4" /note="C2H2-type zinc finger; pfam13894" /db_xref="CDD:464025" Region 649..670 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 676..698 /region_name="zf-C2H2" /note="Zinc finger, C2H2 type; pfam00096" /db_xref="CDD:395048" Region 678..698 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..704 /gene="MSN2" /locus_tag="YMR037C" /coded_by="NM_001182534.1:1..2115" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8650168|PMID:23435728]" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:8321194|PMID:8641288|PMID:8650168]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9472026|PMID:22842922|PMID:12093809|PMID:12732613]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12732613|PMID:12093809|PMID:9472026]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:18070923]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:17914901]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:26947009]" /experiment="EXISTENCE:genetic interaction:GO:0034198 cellular response to amino acid starvation [PMID:17914901]" /experiment="EXISTENCE:genetic interaction:GO:0034224 cellular response to zinc ion starvation [PMID:19702872]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:26947009|PMID:8641288]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:21749328|PMID:17914901|PMID:26947009|PMID:15483057|P MID:20398213|PMID:8641288|PMID:17055490|PMID:11102521|PMID :11179418|PMID:15053871|PMID:16710843|PMID:19073887|PMID:1 5922872|PMID:17150183|PMID:10652100|PMID:27637775|PMID:197 02872]" /experiment="EXISTENCE:genetic interaction:GO:0061433 cellular response to caloric restriction [PMID:20398213]" /experiment="EXISTENCE:genetic interaction:GO:0070301 cellular response to hydrogen peroxide [PMID:10652100|PMID:11102521|PMID:8641288]" /experiment="EXISTENCE:genetic interaction:GO:0070417 cellular response to cold [PMID:15483057|PMID:15053871]" /experiment="EXISTENCE:genetic interaction:GO:0071243 cellular response to arsenic-containing substance [PMID:19073887|PMID:10652100]" /experiment="EXISTENCE:genetic interaction:GO:0071361 cellular response to ethanol [PMID:8641288]" /experiment="EXISTENCE:genetic interaction:GO:0071464 cellular response to hydrostatic pressure [PMID:17055490]" /experiment="EXISTENCE:genetic interaction:GO:0071468 cellular response to acidic pH [PMID:8641288|PMID:11179418|PMID:15922872]" /experiment="EXISTENCE:genetic interaction:GO:0071469 cellular response to alkaline pH [PMID:21749328]" /experiment="EXISTENCE:genetic interaction:GO:0071476 cellular hypotonic response [PMID:8641288|PMID:17914901]" /experiment="EXISTENCE:genetic interaction:GO:0071497 cellular response to freezing [PMID:17150183]" /experiment="EXISTENCE:genetic interaction:GO:0071500 cellular response to nitrosative stress [PMID:16710843]" /experiment="EXISTENCE:genetic interaction:GO:1902075 cellular response to salt [PMID:17914901|PMID:10652100|PMID:8641288]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8650168]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:8650168|PMID:11102521]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16980434|PMID:11102521|PMID:15922872|PMID:8650168]" /experiment="EXISTENCE:mutant phenotype:GO:0070301 cellular response to hydrogen peroxide [PMID:11102521]" /experiment="EXISTENCE:mutant phenotype:GO:0071468 cellular response to acidic pH [PMID:16980434|PMID:15922872]" /note="Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; light sensing pathway component that accumulates in the nucleus in response to blue light; relative distribution to nucleus increases upon DNA replication stress" /db_xref="GeneID:855053" /db_xref="SGD:S000004640" ORIGIN 1 mtvdhdfnse dilfpiesms siqyvennnp nninndvipy sldikntvld sadlndiqnq 61 etslnlglpp lsfdsplpvt etipsttdns lhlkadsnkn rdartiends eikstnnasg 121 sganqyttlt spypmndily nmnnplqsps pssvpqnpti nppintasne tnlspqtsng 181 netlispraq qhtsikdnrl slpngansnl fidtnpnnln eklrnqlnsd tnsysnsisn 241 snsnstgnln ssyfnslnid smlddyvssd lllndddddt nlsrrrfsdv itnqfpsmtn 301 srnsishsld lwnhpkinps nrntnlnitt nstsssnasp ntttmnanad sniagnpknn 361 datidneltq ilneynmnfn dnlgtstsgk nksacpssfd anamtkinps qqlqqqlnrv 421 qhkqltsshn nsstnmksfn sdlysrrqra slpiiddsls ydlvnkqded pkndmlpnsn 481 lsssqqfikp smilsdnasv iakvattgls ndmpflteeg eqnanstpnf dlsitqmnma 541 plspasssst slatnhfyhh fpqqghhtmn skigsslrrr ksavplmgtv pltnqqnnis 601 sssvnstgng agvtkerrps yrrksmtpsr rssvviestk eleekpfhch icpksfkrse 661 hlkrhvrsvh snerpfachi cdkkfsrsdn lsqhikthkk hgdi // LOCUS NP_013752 249 aa linear PLN 30-JUN-2025 DEFINITION copper chaperone CCS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013752 VERSION NP_013752.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182535.1 REFERENCE 1 (residues 1 to 249) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 249) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 249) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 249) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09937. Method: conceptual translation. FEATURES Location/Qualifiers source 1..249 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..249 /product="copper chaperone CCS1" /calculated_mol_wt="27199" Region 15..238 /region_name="PLN02957" /note="copper, zinc superoxide dismutase" /db_xref="CDD:215516" CDS 1..249 /gene="CCS1" /locus_tag="YMR038C" /gene_synonym="LYS7" /coded_by="NM_001182535.1:1..750" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18977757]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11500508]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9295278]" /experiment="EXISTENCE:genetic interaction:GO:0016532 superoxide dismutase copper chaperone activity [PMID:9295278]" /experiment="EXISTENCE:mutant phenotype:GO:0006825 copper ion transport [PMID:9295278]" /experiment="EXISTENCE:mutant phenotype:GO:0016532 superoxide dismutase copper chaperone activity [PMID:9295278]" /note="Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within N-terminus is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress; human homolog CCS can complement yeast ccs1 null mutant" /db_xref="GeneID:855054" /db_xref="SGD:S000004641" ORIGIN 1 mttndtyeat yaipmhcenc vndikaclkn vpginslnfd ieqqimsves svapstiint 61 lrncgkdaii rgagkpnssa vailetfqky tidqkkdtav rglarivqvg enktlfditv 121 ngvpeagnyh asihekgdvs kgvestgkvw hkfdepiecf nesdlgknly sgktflsapl 181 ptwqligrsf viskslnhpe nepssvkdys flgviarsag vwennkqvca ctgktvweer 241 kdalannik // LOCUS NP_013753 292 aa linear PLN 30-JUN-2025 DEFINITION chromatin-binding transcription coactivator SUB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013753 VERSION NP_013753.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182536.1 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09938. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..292 /product="chromatin-binding transcription coactivator SUB1" /calculated_mol_wt="32971" Region 41..94 /region_name="PC4" /note="Transcriptional Coactivator p15 (PC4); pfam02229" /db_xref="CDD:460501" CDS 1..292 /gene="SUB1" /locus_tag="YMR039C" /gene_synonym="TSP1" /coded_by="NM_001182536.1:1..879" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:26147804]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26147804|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19204085]" /experiment="EXISTENCE:direct assay:GO:0033554 cellular response to stress [PMID:19204085]" /experiment="EXISTENCE:direct assay:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:19204085|PMID:19706510]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:25813861]" /experiment="EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:19706510]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19204085]" /experiment="EXISTENCE:genetic interaction:GO:0006369 termination of RNA polymerase II transcription [PMID:11389848]" /experiment="EXISTENCE:genetic interaction:GO:0006972 hyperosmotic response [PMID:19204085]" /experiment="EXISTENCE:genetic interaction:GO:0033554 cellular response to stress [PMID:19204085]" /experiment="EXISTENCE:genetic interaction:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:19204085]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:23554872]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19204085]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:15692559]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:19204085]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:26837954]" /experiment="EXISTENCE:mutant phenotype:GO:0045945 positive regulation of transcription by RNA polymerase III [PMID:19706510|PMID:19204085]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:26837954]" /experiment="EXISTENCE:mutant phenotype:GO:0075297 negative regulation of ascospore formation [PMID:26147804]" /note="Transcriptional regulator; facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in nonhomologous end-joining (NHEJ) of ds breaks in plasmid DNA, but not chromosomal DNA; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes; negatively regulates sporulation; protein abundance increases in response to DNA replication stress; functionally complemented by human SUB1 (PC4)" /db_xref="GeneID:855055" /db_xref="SGD:S000004642" ORIGIN 1 msyynryrnk rrsdngggnl snsnnnnggm psglsasdai fdlgknkrvt vrqfrninli 61 direyyldss tgemkpgkkg isltedlyde llkhrlnide alrrlgskrp ktkmvrllsd 121 deyeddnnnd stnndkdkng kdknspkkrr edkskasnes hdleprskkk kpapptllph 181 eeniqnaere anatliipgq agrkqqeerk qkekeeaeea kakavaeqek eakakekiae 241 pepepvptlq akkedivsni neskdanssd eefaqsleae mnkaeddise ee // LOCUS NP_013754 160 aa linear PLN 30-JUN-2025 DEFINITION Yet2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013754 VERSION NP_013754.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182537.1 REFERENCE 1 (residues 1 to 160) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 160) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 160) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09939. Method: conceptual translation. FEATURES Location/Qualifiers source 1..160 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..160 /product="Yet2p" /calculated_mol_wt="19047" Region 1..160 /region_name="COG5374" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227666" CDS 1..160 /gene="YET2" /locus_tag="YMR040W" /coded_by="NM_001182537.1:1..483" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein that may interact with ribosomes; based on co-purification experiments; homolog of human BAP31 protein; YET2 has a paralog, YET1, that arose from the whole genome duplication" /db_xref="GeneID:855056" /db_xref="SGD:S000004643" ORIGIN 1 mgvylavlfs llviemailf ilvlplpqrm rrwlyirysi istnkkfrty mvgimifvgl 61 lfidswkrsq irvstyrnqk npyiinsvtp vdalasrayn qrnvyisgfi iyfyiciltv 121 msilrrivew ndkmkagddi lkeklrrkqk yleelqkkkf // LOCUS NP_013755 335 aa linear PLN 30-JUN-2025 DEFINITION D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013755 VERSION NP_013755.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182538.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09940. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..335 /product="D-arabinose 1-dehydrogenase (NAD(P)(+)) ARA2" /EC_number="1.1.1.116" /calculated_mol_wt="38089" Region 2..301 /region_name="AKR_ARA2" /note="D-arabinose 1-dehydrogenase (ARA2) and similar proteins; cd19164" /db_xref="CDD:381390" Site order(20..22,53,58,86,124..125,156..157,186,215..221,257, 275..278,283,286..287) /site_type="active" /note="putative active site [active]" /db_xref="CDD:381390" Site order(53,58,86,124) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381390" CDS 1..335 /gene="ARA2" /locus_tag="YMR041C" /coded_by="NM_001182538.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0045290 D-arabinose 1-dehydrogenase [NAD(P)+] activity [PMID:17097644]" /experiment="EXISTENCE:mutant phenotype:GO:0045290 D-arabinose 1-dehydrogenase [NAD(P)+] activity [PMID:17097644]" /experiment="EXISTENCE:mutant phenotype:GO:0070485 dehydro-D-arabinono-1,4-lactone biosynthetic process [PMID:17097644]" /note="NAD-dependent arabinose dehydrogenase; involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase" /db_xref="GeneID:855057" /db_xref="SGD:S000004644" ORIGIN 1 mvnekvnpfd lasvsplvlg gailnqqytd epesipledi ikyafshgin aidtspyygp 61 sevlygrals nlrnefprdt yfictkvgri gaeefnysrd fvrfsvhrsc erlhttyldl 121 vylhdvefvk fpdilealke lrtlknkgvi knfgisgypi dfitwlaeyc steesdigsl 181 davlsycnln lqnnkllnfr erllrnaklk mvcnasilsm sllrsqetrq fhpcshelre 241 casqaakycq eqnvdladla tryaisewvg kgpvvlgvss meelklaldn yeivksngnr 301 lsskdgqlve yiqknifkeh fneewssgip hpemi // LOCUS NP_013756 177 aa linear PLN 30-JUN-2025 DEFINITION Arg80p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013756 VERSION NP_013756.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182539.1 REFERENCE 1 (residues 1 to 177) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 177) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 177) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 177) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09941. Method: conceptual translation. FEATURES Location/Qualifiers source 1..177 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..177 /product="Arg80p" /calculated_mol_wt="19356" Region 1..>177 /region_name="ARG80" /note="Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]; COG5068" /db_xref="CDD:227400" CDS 1..177 /gene="ARG80" /locus_tag="YMR042W" /gene_synonym="ARGR1" /coded_by="NM_001182539.1:1..534" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:12138185]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:3311884]" /experiment="EXISTENCE:mutant phenotype:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:12138185]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8212891]" /experiment="EXISTENCE:mutant phenotype:GO:1900079 regulation of arginine biosynthetic process [PMID:5434281]" /experiment="EXISTENCE:mutant phenotype:GO:1900081 regulation of arginine catabolic process [PMID:12138185]" /note="Transcription factor involved in regulating arginine-responsive genes; acts with Arg81p and Arg82p" /db_xref="GeneID:855059" /db_xref="SGD:S000004645" ORIGIN 1 mtsnsdgsst spvekpitgd vetneptkpi rrlstpspeq dqegdfdeed dddkfsvsts 61 tptptitktk dssdtstvtr rkqpiryien ktrrhvtfsk rrhgimkkay elsvltgani 121 lllilansgl vytfttpkle pvvredegks liracinasd tpdatdtspa qeqspan // LOCUS NP_013757 286 aa linear PLN 30-JUN-2025 DEFINITION transcription factor MCM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013757 VERSION NP_013757.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182540.1 REFERENCE 1 (residues 1 to 286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 286) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09942. Method: conceptual translation. FEATURES Location/Qualifiers source 1..286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..286 /product="transcription factor MCM1" /calculated_mol_wt="32671" Region 18..286 /region_name="ARG80" /note="Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]; COG5068" /db_xref="CDD:227400" CDS 1..286 /gene="MCM1" /locus_tag="YMR043W" /gene_synonym="FUN80" /coded_by="NM_001182540.1:1..861" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9121436]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12473677]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:2673922|PMID:12738768|PMID:1752436]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:11562353]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9121436]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9121436|PMID:12052870]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:12473677]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0044377 RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending [PMID:7739902|PMID:9121436|PMID:9490409|PMID:12509445]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9121436|PMID:11060038|PMID:19233144]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:9490409]" /experiment="EXISTENCE:direct assay:GO:1900080 positive regulation of arginine biosynthetic process [PMID:19233144]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:7565744|PMID:9171372]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16278448|PMID:8455631|PMID:1961765]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10594003]" /experiment="EXISTENCE:mutant phenotype:GO:0031494 regulation of mating type switching [PMID:9620858]" /experiment="EXISTENCE:mutant phenotype:GO:0044377 RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending [PMID:12509445|PMID:15118075|PMID:10594003]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8455631|PMID:7565744|PMID:1961765|PMID:12738768|PMID :16278448|PMID:19233144|PMID:9171372]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12711672|PMID:12052870]" /experiment="EXISTENCE:mutant phenotype:GO:1900080 positive regulation of arginine biosynthetic process [PMID:8455631|PMID:19233144]" /experiment="EXISTENCE:mutant phenotype:GO:1900082 negative regulation of arginine catabolic process [PMID:8455631]" /experiment="EXISTENCE:physical interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:19233144]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12509445|PMID:12711672]" /note="Transcription factor; involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:855060" /db_xref="SGD:S000004646" ORIGIN 1 msdieegtpt nngqqkerrk ieikfienkt rrhvtfskrk hgimkkafel svltgtqvll 61 lvvsetglvy tfstpkfepi vtqqegrnli qaclnapdde eedeeedgdd dddddddgnd 121 mqrqqpqqqq pqqqqqvlna hanslghlnq dqvpagalkq evksqllgga npnqnsmiqq 181 qqhhtqnsqp qqqqqqqpqq qmsqqqmsqh prpqqgiphp qqsqpqqqqq qqqqlqqqqq 241 qqqqqpltgi hqphqqafan aaspylnaeq naayqqyfqe pqqgqy // LOCUS NP_013758 475 aa linear PLN 30-JUN-2025 DEFINITION Ioc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013758 VERSION NP_013758.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182541.1 REFERENCE 1 (residues 1 to 475) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 475) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 475) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 475) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09943. Method: conceptual translation. FEATURES Location/Qualifiers source 1..475 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..475 /product="Ioc4p" /calculated_mol_wt="55296" Region 10..162 /region_name="PWWP_ScIOC4-like" /note="PWWP domain found in Saccharomyces cerevisiae ISWI one complex protein 4 (ScIOC4) and similar proteins; cd05840" /db_xref="CDD:438965" Site order(19,22,115) /site_type="other" /note="putative methyl-histone binding site [polypeptide binding]" /db_xref="CDD:438965" Site 20..23 /site_type="other" /note="PWWP sequence motif" /db_xref="CDD:438965" CDS 1..475 /gene="IOC4" /locus_tag="YMR044W" /coded_by="NM_001182541.1:1..1428" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12482963]" /experiment="EXISTENCE:direct assay:GO:0036437 Isw1b complex [PMID:12482963]" /experiment="EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:27185881]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:12482963]" /note="Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing" /db_xref="GeneID:855061" /db_xref="SGD:S000004647" ORIGIN 1 mseaifqptd ivlakvkgfs awpamiipne lipdnilktk pvsvhkgksg sdkkanedid 61 admeseardr eqseeeedie dfgeseanpe kfiiytpvlk frkndtlkst ycvkffcdds 121 yiwvkpmdmk iltsedcrkw lsgkqrknkk lipayemamr gkngidiwef veygsygkpd 181 eeeyveeeee enepekkair ptrsssrqrq krasetekse ggnsnkrkrv trstrqqaid 241 aseeeeeeee ekvqeavrkr pqrtktkkvv vsktkpnpkt kakkekpkpp kpikyhfedd 301 edwsivglgp qdlsiektmd piakklsqkk nlekhveikl dledklagin kllcdvlcsa 361 inqavsikdd feiildelqi aldtrgsrne fitifqsnns lllnfrilfn lrkrelnkwd 421 lwdrfqdifk hiysyqfipd tedwqleqnm eieemdrekp sfsedvkeee skvga // LOCUS NP_013759 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013759 VERSION NP_013759.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182542.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09944. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198769" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region <907..1163 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YMR045C" /coded_by="join(NM_001182542.2:1..1305, NM_001182542.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:855062" /db_xref="SGD:S000004648" ORIGIN 1 mesqqlsqhs pishgsacas vtskevqttq dpldisaskt eecekvstqa nsqqpttpls 61 savpenhhha spqaaqvplp qngpypqqrm mntqqanisg wpvyghpslm pyppyqmspm 121 yappgaqsqf tqypqyvgth lntpspesgn sfpdsssaks nmtstnqhvr pppiltspnd 181 flnwvkiyik flqnsnlgdi iptatrkavr qmtddeltfl chtfqlfaps qflppwvkdi 241 lsvdytdimk ilsksinkmq sdtqevndit tlatlhyngs tpadafeaev tnildrlnnn 301 gipinnkvac qfimrglsge ykflryarhr cihmtvadlf sdihsmyeeq qeskrnksth 361 rrspsdekkd srtytnttkp ksitrnsqkp nnsqsrtara hnvstfnnsp gpdndlirgs 421 ttepiqlknt hdlhlgqelt estvnhtnhs ddklpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqqsn dlniesdhdf qsdielhpeq lrnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis diestgsggm 1021 hrldvpllap msqsnthess haskskdfrh sdsysdnetn htnvpisstg gtnnktvpqt 1081 seqetekrii hrspsidtss sesnslhhvv piktsdtcpk enteesiiad lplpdlppep 1141 ptelsdsfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd kyydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfensqv ticlfvddmv lfsknlnsnk 1441 riidklkmqy dtkiinlges deeiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqq eleleeddyk mkvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsk qvldmtyeli qfiwntrdkq liwhkskpvk ptnklvvisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qeldkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_013760 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013760 VERSION NP_013760.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182543.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09945. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..440 /product="gag protein" /calculated_mol_wt="49143" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YMR046C" /coded_by="NM_001182543.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:855063" /db_xref="SGD:S000004649" ORIGIN 1 mesqqlsqhs pishgsacas vtskevqttq dpldisaskt eecekvstqa nsqqpttpls 61 savpenhhha spqaaqvplp qngpypqqrm mntqqanisg wpvyghpslm pyppyqmspm 121 yappgaqsqf tqypqyvgth lntpspesgn sfpdsssaks nmtstnqhvr pppiltspnd 181 flnwvkiyik flqnsnlgdi iptatrkavr qmtddeltfl chtfqlfaps qflppwvkdi 241 lsvdytdimk ilsksinkmq sdtqevndit tlatlhyngs tpadafeaev tnildrlnnn 301 gipinnkvac qfimrglsge ykflryarhr cihmtvadlf sdihsmyeeq qeskrnksth 361 rrspsdekkd srtytnttkp ksitrnsqkp nnsqsrtara hnvstfnnsp gpdndlirgs 421 ttepiqlknt hdlhlrpgty // LOCUS NP_013762 1113 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin NUP116 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013762 VERSION NP_013762.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182544.1 REFERENCE 1 (residues 1 to 1113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1113) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09946. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1113 /product="FG-nucleoporin NUP116" /calculated_mol_wt="116104" Region <184..761 /region_name="FhaB" /note="Large exoprotein involved in heme utilization or adhesion [Intracellular trafficking, secretion, and vesicular transport]; COG3210" /db_xref="CDD:442443" Region 970..1108 /region_name="Nucleoporin2" /note="Nucleoporin autopeptidase; pfam04096" /db_xref="CDD:461171" CDS 1..1113 /gene="NUP116" /locus_tag="YMR047C" /gene_synonym="NSP116" /coded_by="NM_001182544.1:1..3342" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:1385442]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:14960378]" /experiment="EXISTENCE:genetic interaction:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:10952996]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:17875746|PMID:11387327]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:9802895|PMID:8524308]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:8557738]" /experiment="EXISTENCE:mutant phenotype:GO:0006999 nuclear pore organization [PMID:9463388]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:8557738|PMID:9802895]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:17418788]" /experiment="EXISTENCE:physical interaction:GO:0006406 mRNA export from nucleus [PMID:11104765]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788|PMID:17803941|PMID:12917401]" /note="FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup159p); NUP116 has a paralog, NUP100, that arose from the whole genome duplication" /db_xref="GeneID:855066" /db_xref="SGD:S000004650" ORIGIN 1 mfgvsrgafp sattqpfgst gstfggqqqq qqpvantsaf glsqqtnttq apafgnfgnq 61 tsnspfgmsg sttangtpfg qsqltnnnas gsifggmgnn talsagsasv vpnstagtsi 121 kpfttfeekd pttgvinvfq sitcmpeyrn fsfeelrfqd yqagrkfgts qngtgttfnn 181 pqgttntgfg imgnnnstts attgglfgqk patgmfgtgt gsgggfgsga tnstglfgss 241 tnlsgnsafg ankpatsggl fgnttnnptn gtnntglfgq qnsntngglf gqqqnsfgan 301 nvsnggafgq vnrgafpqqq tqqgsggifg qsnanangga fgqqqgtgal fgakpasggl 361 fgqsagskaf gmntnptgtt gglfgqtnqq qsggglfgqq qnsnagglfg qnnqsqnqsg 421 lfgqqnssna fgqpqqqggl fgskpagglf gqqqgastfa sgnaqnnsif gqnnqqqqst 481 gglfgqqnnq sqsqpgglfg qtnqnnnqpf gqnglqqpqq nnslfgakpt gfgntslfsn 541 sttnqsngis gnnlqqqsgg lfqnkqqpas gglfgskpsn tvggglfgnn qvanqnnpas 601 tsgglfgskp atgslfggtn stapnassgg ifgsnnasnt aattnstglf gnkpvgagas 661 tsagglfgnn nnsslnnsng stglfgsnnt sqstnagglf qnntstntsg gglfsqpsqs 721 maqsqnalqq qqqqqrlqiq nnnpygtnel fskatvtntv sypiqpsatk ikaderkkas 781 ltnaykmipk tlftaklktn nsvmdkaqik vdpklsisid kknnqiaisn qqeenldesi 841 lkasellfnp dkrsfknlin nrkmliasee knngsqnndm nfkskseeqe tilgkpkmde 901 ketanggerm vlsskndged satkhhsrnm deenkenvad lqkqeysedd kkavfadvae 961 kdasfineny yispsldtls sysllqlrkv phlvvghksy gkieflepvd lagipltslg 1021 gviitfepkt ciiyanlpnr pkrgeginvr aritcfncyp vdkstrkpik dpnhqlvkrh 1081 ierlkknpns kfesydadsg tyvfivnhaa eqt // LOCUS NP_013763 317 aa linear PLN 30-JUN-2025 DEFINITION Csm3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013763 VERSION NP_013763.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182545.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09947. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..317 /product="Csm3p" /calculated_mol_wt="36224" Region 53..137 /region_name="Swi3" /note="Replication Fork Protection Component Swi3; pfam07962" /db_xref="CDD:462324" CDS 1..317 /gene="CSM3" /locus_tag="YMR048W" /coded_by="NM_001182545.1:1..954" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:19819872]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:16219777]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:17483413|PMID:14742714]" /experiment="EXISTENCE:genetic interaction:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:16219777]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714|PMID:17483413]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /experiment="EXISTENCE:mutant phenotype:GO:0043111 replication fork arrest [PMID:16418273|PMID:16103218]" /experiment="EXISTENCE:mutant phenotype:GO:0043570 maintenance of DNA repeat elements [PMID:18321795]" /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:11470404]" /note="Subunit of a replication-pausing checkpoint complex; the replication fork protection complex (Tof1p-Mrc1p-Csm3p) acts at stalled replication forks and is required for rapid replication fork progression, replisome stabilization under stress, mediating DNA replication checkpoint signaling and promoting sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:855067" /db_xref="SGD:S000004651" ORIGIN 1 mdqdfdslll gfndsdsvqk dptvpngldg svvdptiadp taitarkrrp qvkltaekll 61 sdkglpyvlk nahkririss kknsydnlsn iiqfyqlwah elfpkakfkd fmkicqtvgk 121 tdpvlreyrv slfrdemgms fdvgtretgq dlerqspmve ehvtsaeerp ivadsfaqdk 181 rnvnnvdydn dedddiyhls yrnrrgrvld ergnnetvln nvvppkedld allktfrvqg 241 pvgleenekk lllgwldahr kmekgsmtee dvqliqslee wemndiegqh thydllpggd 301 efgvdqdeld amkemgf // LOCUS NP_013764 807 aa linear PLN 30-JUN-2025 DEFINITION ribosome biogenesis protein ERB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013764 VERSION NP_013764.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182546.1 REFERENCE 1 (residues 1 to 807) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 807) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 807) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 807) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 807) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09948. Method: conceptual translation. FEATURES Location/Qualifiers source 1..807 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..807 /product="ribosome biogenesis protein ERB1" /calculated_mol_wt="91574" Region 165..426 /region_name="BOP1NT" /note="BOP1NT (NUC169) domain; pfam08145" /db_xref="CDD:462371" Region 429..805 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(436,454,458,464..465,477,487,513,537,575..576,593, 610,615,624..625,638,655,665..666,678..679,697,701,706,708, 721..722,739,744,750,757,772..773,795,799,805) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 441..483 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 488..540 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 598..637 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 642..676 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 684..720 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 726..771 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..807 /gene="ERB1" /locus_tag="YMR049C" /coded_by="NM_001182546.1:1..2424" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350|PMID:23212245]" /experiment="EXISTENCE:direct assay:GO:0070545 PeBoW complex [PMID:16287855]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11522832]" /experiment="EXISTENCE:physical interaction:GO:0042273 ribosomal large subunit biogenesis [PMID:16287855]" /experiment="EXISTENCE:physical interaction:GO:0070545 PeBoW complex [PMID:16287855]" /note="Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; binds RNA via its C-terminal domain; homologous to mammalian Bop1" /db_xref="GeneID:855068" /db_xref="SGD:S000004652" ORIGIN 1 mmaknnktte akmskkraas eesdveeded kllsvdglid aeasesdedd deyesaveek 61 esssdkeaqd dsdddsdael nkllaeeegd geedydssef sddttsltdr lsgvklqtiv 121 dpniyskyad gsdriikpei npvydsddsd aetqntigni plsaydemph igydingkri 181 mrpakgsald qlldsielpe gwtglldkns gsslnltkee leliskiqrn eqtddsinpy 241 eplidwftrh eevmpltavp epkrrfvpsk neakrvmkiv rairegriip pkklkemkek 301 ekienyqydl wgdstetndh vmhlrapklp pptneesynp peeyllspee keawenteys 361 erernfipqk ysalrkvpgy gesirerfer sldlylaprv rknklnidpn slipelpspk 421 dlrpfpircs tiyaghkgkv rtlsidpsgl wlatgsddgt vrvweiltgr evyrttlidd 481 eenpdyhiec iewnpdanng ilavavgeni hlivppifgy dienngktki edgfgydtfg 541 tvkksnlevn engdgdedge nesaknavkk qvaqwnkpsq kqlekdicit isckktvkkl 601 swhrkgdyfv tvqpdsgnts vlihqvskhl tqspfkkskg iimdakfhpf kpqlfvcsqr 661 yvriydlsqq ilvkkllpga rwlskidihp rgdnliassf dkrvlwhdld lastpyktlr 721 yhekavrsvn fhkklplfss aaddgtihvf hatvyddmmk npmivplkkl tghkvinslg 781 vldaiwhpre awlfsagadn tarlwtt // LOCUS NP_013765 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013765 VERSION NP_013765.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182547.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09949. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198425" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YMR050C" /coded_by="join(NM_001182547.2:1..1305, NM_001182547.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:855070" /db_xref="SGD:S000004653" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsd dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky iqayhkevnq 1261 llkmktwdtd ryydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydpgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqq eleleeddyk mkvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsk qvldmtyeli qfiwntrdkq liwhkskpvk ptnklvvisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlshlv qelnkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_013766 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013766 VERSION NP_013766.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182548.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09950. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..440 /product="gag protein" /calculated_mol_wt="48998" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YMR051C" /coded_by="NM_001182548.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:855071" /db_xref="SGD:S000004654" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_013767 204 aa linear PLN 30-JUN-2025 DEFINITION Far3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013767 VERSION NP_013767.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182550.1 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09951. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..204 /product="Far3p" /calculated_mol_wt="23901" CDS 1..204 /gene="FAR3" /locus_tag="YMR052W" /coded_by="NM_001182550.1:1..615" /experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:22782902]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23625923|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]" /experiment="EXISTENCE:mutant phenotype:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]" /note="hypothetical protein; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855073" /db_xref="SGD:S000004656" ORIGIN 1 mnsggsdsfd yllqltkals aecranrqet drielllkrl akqsgisydn lskniipdsw 61 kdnasqkasp pteaqklise nfkliyeiek qeyfntkava linninehfs yiknfideqn 121 airerniatf ssekldernk slqqnyeslk teneetkkkl hsiikqfekl lkevdwdris 181 kdsrdysrfk kqleylqdty qvlk // LOCUS NP_013769 850 aa linear PLN 30-JUN-2025 DEFINITION Stb2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013769 VERSION NP_013769.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182551.1 REFERENCE 1 (residues 1 to 850) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 850) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 850) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 850) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 850) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 850) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 850) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09952. Method: conceptual translation. FEATURES Location/Qualifiers source 1..850 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..850 /product="Stb2p" /calculated_mol_wt="97697" CDS 1..850 /gene="STB2" /locus_tag="YMR053C" /coded_by="NM_001182551.1:1..2553" /experiment="EXISTENCE:direct assay:GO:0070822 Sin3-type complex [PMID:9393435]" /experiment="EXISTENCE:physical interaction:GO:0070822 Sin3-type complex [PMID:9393435]" /note="Protein that interacts with Sin3p in a two-hybrid assay; part of a large protein complex with Sin3p and Stb1p; STB2 has a paralog, STB6, that arose from the whole genome duplication" /db_xref="GeneID:855075" /db_xref="SGD:S000004657" ORIGIN 1 mvmadtiatg dktsqfdgkh mqdleriyst rdtlddnffg ergqkdangd yydelnneet 61 nysgssyygh sddsevvgli kndtvsqlpp ldsfifpdsr alflldlgny adltyeeiiv 121 hgfeiyiveq wvacrnlstl itsytgnsqd tisgvrvvlp kdtsmwpgrf rlyfeelmef 181 arpkftpkgt lfitnlsgvs fglnllhvec gdlrtiwkdf evnfdlknlh cggrsanllc 241 pptmasldkf sqlfkiptng fiaqypqmiq qqqprlpeee yktvgnskcr ntdskspvve 301 mvtliqisls yfnllsknyq tdgllcedtk raidewwety gklylgtekp rnectlgptt 361 vaglislilc cyfklmienc isskdpfdea gffqgiynfq kkhglnkrks rvyldprtle 421 klfevtakvs skdifklkkm vtstvqdiig kgnpinlshk ilttdldtli hnihggsvgl 481 lwkgkghprk cctdisneef lkfnyqrgdp dgqirereml lekfrleria yaqkhaskkv 541 ssssldtsed igrtnampss atvssmfpny dntkyaynfg inklyqgeyy rrnsfpyckd 601 rthdniyedl selkekssrl yrcnsssavq nivekwdlpf dpsvvriard llrmkydiqa 661 qqhiqemdeh ymgklnkegt vgqyskfner ykrlqelykk ysdgakvfeg rfedidnkqq 721 lllhemqeln slssrlkydm rilevrvrdi essvaqfdsk liglksslqg qgktgicsai 781 dpksdkdeyd rcvndlmttn nptyealclk mlsrryfkdl kndtvgwfrw lfgnnslhnn 841 aseddrgirv // LOCUS NP_013770 890 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V0 sector ATPase subunit a [Saccharomyces cerevisiae S288C]. ACCESSION NP_013770 VERSION NP_013770.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182552.1 REFERENCE 1 (residues 1 to 890) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 890) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 890) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 890) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 890) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 890) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 890) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09953. Method: conceptual translation. FEATURES Location/Qualifiers source 1..890 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..890 /product="H(+)-transporting V0 sector ATPase subunit a" /calculated_mol_wt="101530" Region 32..885 /region_name="V_ATPase_I" /note="V-type ATPase 116kDa subunit family; pfam01496" /db_xref="CDD:460232" CDS 1..890 /gene="STV1" /locus_tag="YMR054W" /coded_by="NM_001182552.1:1..2673" /experiment="EXISTENCE:direct assay:GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain [PMID:7514599]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:11592965]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:11948198|PMID:11592965]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:28720663]" /experiment="EXISTENCE:genetic interaction:GO:0007035 vacuolar acidification [PMID:11278748|PMID:7514599]" /experiment="EXISTENCE:genetic interaction:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:7514599]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:11278748]" /experiment="EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:28720663]" /note="Subunit a of vacuolar-ATPase V0 domain; encodes one of two isoforms, located in both Golgi and endosomal V-ATPase complexes while VPH1 encodes second isoform and is located in vacuolar V-ATPase complexes; interaction with PI(4)P is required for efficient localization and function of Stv1-containing V-ATPases; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:855076" /db_xref="SGD:S000004658" ORIGIN 1 mnqeeaifrs admtyvqlyi plevirevtf llgkmsvfmv mdlnkdltaf qrgyvnqlrr 61 fdevermvgf lnevvekhaa etwkyilhid degndiaqpd madlintmep lslenvndmv 121 keitdcesra rqldesldsl rsklndlleq rqvifecskf ievnpgiagr atnpeieqee 181 rdvdefrmtp ddisetlsda fsfddetpqd rgalgndltr nqsvedlsfl eqgyqhrymi 241 tgsirrtkvd ilnrilwrll rgnlifqnfp ieepllegke kvekdcfiif thgetllkkv 301 krvidslngk ivslntrsse lvdtlnrqid dlqrildtte qtlhtellvi hdqlpvwsam 361 tkrekyvytt lnkfqqesqg liaegwvpst elihlqdslk dyietlgsey stvfnviltn 421 klpptyhrtn kftqafqsiv daygiatyke inaglatvvt fpfmfaimfg dmghgfilfl 481 malflvlner kfgamhrdei fdmaftgryv lllmgafsvy tgllyndifs ksmtifksgw 541 qwpstfrkge sieakktgvy pfgldfawhg tdngllfsns ykmklsilmg yahmtysfmf 601 syinyrakns kvdiignfip glvfmqsifg ylswaivykw skdwikddkp apgllnmlin 661 mflapgtidd qlysgqaklq vvlllaalvc vpwlllykpl tlrrlnkngg ggrphgyqsv 721 gnieheeqia qqrhsaegfq gmiisdvasv adsinesvgg geqgpfnfgd vmihqvihti 781 efclncisht asylrlwals lahaqlssvl wdmtisnafs sknsgsplav mkvvflfamw 841 fvltvcilvf megtsamlha lrlhwveams kffegegyay epfsfraiie // LOCUS NP_013771 306 aa linear PLN 30-JUN-2025 DEFINITION Bub2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013771 VERSION NP_013771.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182553.1 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09954. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..306 /product="Bub2p" /calculated_mol_wt="34897" Region <1..304 /region_name="COG5210" /note="GTPase-activating protein [General function prediction only]" /db_xref="CDD:227535" CDS 1..306 /gene="BUB2" /locus_tag="YMR055C" /gene_synonym="PAC7" /coded_by="NM_001182553.1:1..921" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:18667533|PMID:25658911|PMID:12048186]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10220406|PMID:10352016]" /experiment="EXISTENCE:direct assay:GO:1990334 Bfa1-Bub2 complex [PMID:25658911]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:25658911]" /experiment="EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:25658911|PMID:16039591]" /experiment="EXISTENCE:mutant phenotype:GO:1902543 negative regulation of protein localization to mitotic spindle pole body [PMID:25658911]" /experiment="EXISTENCE:physical interaction:GO:1990334 Bfa1-Bub2 complex [PMID:11493673]" /note="Mitotic exit network regulator; forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage" /db_xref="GeneID:855077" /db_xref="SGD:S000004659" ORIGIN 1 mtsiedlisn pplllhssls qlrylilseg lpisedkqqq rtrcyvwtvl sqtsmeastq 61 rylallklgp psttiyqkik ndtsrtfqtd pnfrnrvsed alirclscfa wqtqqrrqkt 121 rfgripvsty vqgmnvllap llyscpsepm ayqlftklcy emiptyltkn lngaqngakl 181 ldislriidp klskflsdnl ltaeiygmps iltlsscnkp ldqviklwdf mfaygfhmni 241 lfvvaflvkm rskvfksdsp vnllrqfpdf dadeiirlgv gfiakipaqi ydllvdhltd 301 pdiyip // LOCUS NP_013772 309 aa linear PLN 30-JUN-2025 DEFINITION ADP/ATP carrier protein AAC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013772 VERSION NP_013772.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182554.1 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09955. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..309 /product="ADP/ATP carrier protein AAC1" /calculated_mol_wt="33990" Region 9..303 /region_name="PTZ00169" /note="ADP/ATP transporter on adenylate translocase; Provisional" /db_xref="CDD:240302" CDS 1..309 /gene="AAC1" /locus_tag="YMR056C" /coded_by="NM_001182554.1:1..930" /experiment="EXISTENCE:direct assay:GO:0005471 ATP:ADP antiporter activity [PMID:2167309]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12740376]" /experiment="EXISTENCE:genetic interaction:GO:0006783 heme biosynthetic process [PMID:18728780]" /experiment="EXISTENCE:genetic interaction:GO:0006839 mitochondrial transport [PMID:2167309]" /experiment="EXISTENCE:genetic interaction:GO:0009060 aerobic respiration [PMID:2167309]" /experiment="EXISTENCE:mutant phenotype:GO:0015886 heme transport [PMID:18728780]" /note="Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress" /db_xref="GeneID:855078" /db_xref="SGD:S000004660" ORIGIN 1 mshtetqtqq shfgvdflmg gvsaaiaktg aapiervkll mqnqeemlkq gsldtrykgi 61 ldcfkrtath egivsfwrgn tanvlryfpt qalnfafkdk iksllsydre rdgyakwfag 121 nlfsggaagg lsllfvysld yartrlaada rgskstsqrq fnglldvykk tlktdgllgl 181 yrgfvpsvlg iivyrglyfg lydsfkpvll tgalegsfva sfllgwvitm gastasypld 241 tvrrrmmmts gqtikydgal dclrkivqke gayslfkgcg anifrgvaaa gvislydqlq 301 limfgkkfk // LOCUS NP_013774 636 aa linear PLN 30-JUN-2025 DEFINITION ferroxidase FET3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013774 VERSION NP_013774.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182556.1 REFERENCE 1 (residues 1 to 636) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 636) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 636) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 636) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09956. Method: conceptual translation. FEATURES Location/Qualifiers source 1..636 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..636 /product="ferroxidase FET3" /EC_number="1.16.3.1" /EC_number="1.16.3.4" /calculated_mol_wt="72229" Region 24..144 /region_name="CuRO_1_Fet3p" /note="The first Cupredoxin domain of multicopper oxidase Fet3P; cd13851" /db_xref="CDD:259920" Site order(37..38,40,43,45,53,83,120..125,131,133..135,138,140, 142) /site_type="other" /note="Domain 2 interface [polypeptide binding]" /db_xref="CDD:259920" Site order(81,83..84,86,88..92,94,96,98..101,124,126,128, 130..131,133) /site_type="other" /note="Domain 3 interface [polypeptide binding]" /db_xref="CDD:259920" Region 154..301 /region_name="CuRO_2_Fet3p_like" /note="The second Cupredoxin domain of multicopper oxidase Fet3P; cd13877" /db_xref="CDD:259945" Site order(156..159,163,190,193..196,200,210,212,214,237..239, 254,256,293,295..296) /site_type="other" /note="Domain 1 interface [polypeptide binding]" /db_xref="CDD:259945" Site order(219,221,233..234,236..240,242..244,246,250,252..257) /site_type="other" /note="Domain 3 interface [polypeptide binding]" /db_xref="CDD:259945" Region 336..489 /region_name="CuRO_3_Fet3p" /note="The third Cupredoxin domain of multicopper oxidase Fet3p; cd13899" /db_xref="CDD:259966" Site order(347,351,353,412,414,455..459,461,485..489) /site_type="other" /note="Domain 2 interface [polypeptide binding]" /db_xref="CDD:259966" Site order(362,365,368..370,416,418..421,458..459,476,479..481, 483,485,487) /site_type="other" /note="Domain 1 interface [polypeptide binding]" /db_xref="CDD:259966" CDS 1..636 /gene="FET3" /locus_tag="YMR058W" /coded_by="NM_001182556.1:1..1911" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004322 ferroxidase activity [PMID:9722559|PMID:8599111]" /experiment="EXISTENCE:direct assay:GO:0005381 iron ion transmembrane transporter activity [PMID:16700543]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16700543|PMID:9162052]" /experiment="EXISTENCE:direct assay:GO:0033573 high-affinity iron permease complex [PMID:16522632]" /experiment="EXISTENCE:genetic interaction:GO:0034755 iron ion transmembrane transport [PMID:8599111]" /experiment="EXISTENCE:genetic interaction:GO:1901684 arsenate ion transmembrane transport [PMID:23295455]" /experiment="EXISTENCE:mutant phenotype:GO:0033215 reductive iron assimilation [PMID:16700543]" /experiment="EXISTENCE:mutant phenotype:GO:0034755 iron ion transmembrane transport [PMID:8293473|PMID:8599111|PMID:16700543]" /experiment="EXISTENCE:mutant phenotype:GO:0046688 response to copper ion [PMID:12954629]" /note="Ferro-O2-oxidoreductase; multicopper oxidase that oxidizes ferrous (Fe2+) to ferric iron (Fe3+) for subsequent cellular uptake by transmembrane permease Ftr1p; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855080" /db_xref="SGD:S000004662" ORIGIN 1 mtnallsiav llfsmlslaq aethtfnwtt gwdyrnvdgl ksrpvitcng qfpwpditvn 61 kgdrvqiylt ngmnntntsm hfhglfqngt asmdgvpflt qcpiapgstm lynftvdynv 121 gtywyhshtd gqyedgmkgl fiikddsfpy dydeelslsl sewyhdlvtd ltksfmsvyn 181 ptgaepipqn livnntmnlt wevqpdttyl lrivnvggfv sqyfwiedhe mtvveidgit 241 teknvtdmly itvaqrytvl vhtkndtdkn faimqkfddt mldvipsdlq lnatsymvyn 301 ktaalptqny vdsidnfldd fylqpyekea iygepdhvit vdvvmdnlkn gvnyaffnni 361 tytapkvptl mtvlssgdqa nnseiygsnt htfilekdei veivlnnqdt gthpfhlhgh 421 afqtiqrdrt yddalgevph sfdpdnhpaf peypmrrdtl yvrpqsnfvi rfkadnpgvw 481 ffhchiewhl lqglglvlve dpfgiqdahs qqlsenhlev cqscsvateg naaantldlt 541 dltgenvqha fiptgftkkg iiamtfscfa gilgiitiai ygmmdmedat ekvirdlhvd 601 pevllnevde neerqvnedr hstekhqflt kakrff // LOCUS NP_013775 128 aa linear PLN 30-JUN-2025 DEFINITION Sen15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013775 VERSION NP_013775.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182557.1 REFERENCE 1 (residues 1 to 128) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 128) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 128) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 128) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09957. On May 22, 2006 this sequence version replaced NP_013775.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..128 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..128 /product="Sen15p" /calculated_mol_wt="14759" Region 9..128 /region_name="Sen15" /note="Sen15 protein; pfam09631" /db_xref="CDD:462844" CDS 1..128 /gene="SEN15" /locus_tag="YMR059W" /coded_by="NM_001182557.1:1..387" /experiment="EXISTENCE:direct assay:GO:0000213 tRNA-intron lyase activity [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0000214 tRNA-intron endonuclease complex [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0000379 tRNA-type intron splice site recognition and cleavage [PMID:9200603]" /note="Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface" /db_xref="GeneID:855081" /db_xref="SGD:S000004663" ORIGIN 1 mattdiislv knnllyfqmw teveilqddl swkgnslrll rgrpphklsn dvdtehensl 61 ssprplefil pinmsqyken fltleclsqt fthlcspste rillaiindd gtivyyfvyk 121 gvrkpkrn // LOCUS NP_013776 327 aa linear PLN 30-JUN-2025 DEFINITION SAM complex subunit SAM37 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013776 VERSION NP_013776.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182558.1 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09958. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..327 /product="SAM complex subunit SAM37" /calculated_mol_wt="37362" Region 22..162 /region_name="Tom37" /note="Outer mitochondrial membrane transport complex protein; pfam10568" /db_xref="CDD:463150" Region 183..326 /region_name="Tom37_C" /note="Tom37 C-terminal domain; pfam11801" /db_xref="CDD:432084" CDS 1..327 /gene="SAM37" /locus_tag="YMR060C" /gene_synonym="MAS37; PET3027; TOM37" /coded_by="NM_001182558.1:1..984" /experiment="EXISTENCE:direct assay:GO:0001401 SAM complex [PMID:12891361]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:21299651]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:18039934]" /experiment="EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:18039934|PMID:12891361]" /note="Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability" /db_xref="GeneID:855082" /db_xref="SGD:S000004664" ORIGIN 1 mvkgsvhlwg kdgkaslisv dsialvwfik lctseeaksm vaglqivfsn ntdlssdgkl 61 pvlildngtk vsgyvnivqf lhknictsky ekgtdyeedl aivrkkdrll eysllnyvdv 121 eisrltdyql flntknyney tkklfsklly fpmwyntplq lrsqarence eiigsltled 181 deefveskam esasqlaqsk tfkiahknki kgkqelqqvk ynlqfdnrlq scvsnwlaar 241 kklddsvils sdllflanly vqlglpdgnr irskleqtfg sellnsmsnk iddfvhrpsn 301 nleqrdpqfr eqgnvvmsly nlackyi // LOCUS NP_013777 677 aa linear PLN 30-JUN-2025 DEFINITION cleavage polyadenylation factor subunit RNA14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013777 VERSION NP_013777.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182559.1 REFERENCE 1 (residues 1 to 677) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 677) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 677) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 677) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 677) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 677) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 677) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09959. Method: conceptual translation. FEATURES Location/Qualifiers source 1..677 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..677 /product="cleavage polyadenylation factor subunit RNA14" /calculated_mol_wt="79830" Region 1..677 /region_name="RNA14" /note="Pre-mRNA 3'-end processing (cleavage and polyadenylation) factor [RNA processing and modification]; COG5107" /db_xref="CDD:227438" CDS 1..677 /gene="RNA14" /locus_tag="YMR061W" /coded_by="NM_001182559.1:1..2034" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:15215336]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:10660071]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10660071]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11344258]" /experiment="EXISTENCE:mutant phenotype:GO:0072423 response to DNA damage checkpoint signaling [PMID:24603480]" /experiment="EXISTENCE:physical interaction:GO:0005848 mRNA cleavage stimulating factor complex [PMID:11344258]" /note="Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping and maintenance of genome stability; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:855083" /db_xref="SGD:S000004665" ORIGIN 1 msssttpdll ypsadkvaep sdnihgdelr lrerikdnpt nilsyfqliq yletqesyak 61 vrevyeqfhn tfpfyspawt lqlkgelard efetvekila qclsgklenn dlslwstyld 121 yirrknnlit ggqearaviv kafqlvmqkc aifepksssf wneylnfleq wkpfnkweeq 181 qridmlrefy kkmlcvpfdn lekmwnrytq weqeinslta rkfigelsae ymkarslyqe 241 wlnvtnglkr aspinlrtan kknipqpgts dsniqqlqiw lnwikweren klmlsedmls 301 qrisyvykqg iqymifsaem wydysmyise nsdrqnilyt allanpdsps ltfklsecye 361 ldndsesvsn cfdkctqtll sqykkiasdv nsgednntey eqellykqre kltfvfcvym 421 ntmkrisgls aartvfgkcr klkrilthdv yvenaylefq nqndyktafk vlelglkyfq 481 ndgvyinkyl dfliflnkds qiktlfetsv ekvqdltqlk eiykkmisye skfgnlnnvy 541 slekrfferf pqenlievft sryqiqnsnl ikkleltymy neeedsyfss gngdghhgsy 601 nmsssdrkrl meetgnngnf snkkfkrdse lptevldlls vipkrqyfnt nlldaqklvn 661 flndqveipt vestksg // LOCUS NP_013778 441 aa linear PLN 30-JUN-2025 DEFINITION glutamate N-acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013778 VERSION NP_013778.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182560.1 REFERENCE 1 (residues 1 to 441) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 441) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 441) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 441) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 441) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09960. Method: conceptual translation. FEATURES Location/Qualifiers source 1..441 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..441 /product="glutamate N-acetyltransferase" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /calculated_mol_wt="47718" Region 22..441 /region_name="ArgJ" /note="glutamate N-acetyltransferase/amino-acid acetyltransferase; TIGR00120" /db_xref="CDD:161718" Site order(69..73,105,139..140,208,212,249..252,330..332, 335..336,338..339,341,343..346,348..349,352..355,385, 428..430) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:239065" Site order(136..137,177..178,204,207,215,436,440..441) /site_type="active" /note="active site pocket [active]" /db_xref="CDD:239065" Site 214..215 /site_type="active" /note="cleavage site [active]" /db_xref="CDD:239065" CDS 1..441 /gene="ARG7" /locus_tag="YMR062C" /gene_synonym="ECM40" /coded_by="NM_001182560.1:1..1326" /experiment="EXISTENCE:direct assay:GO:0004042 L-glutamate N-acetyltransferase activity [PMID:9428669]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:205532]" /experiment="EXISTENCE:direct assay:GO:0006592 ornithine biosynthetic process [PMID:9428669]" /note="Mitochondrial ornithine acetyltransferase; catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine" /db_xref="GeneID:855084" /db_xref="SGD:S000004666" ORIGIN 1 mrisstllqr skqlidkyal yvpktgsfpk gfevgytasg vkkngsldlg vilntnksrp 61 staaavfttn kfkaapvlts kkvletargk ninaivvnsg cansvtgdlg mkdaqvmidl 121 vndkigqkns tlvmstgvig qrlqmdkist ginkifgeek fgsdfnswln vaksicttdt 181 fpklvtsrfk lpsgteytlt gmakgagmic pnmatllgfi vtdlpieska lqkmltfatt 241 rsfncisvdg dmstndticm langaidtke inedskdfeq vklqvtefaq rlaqlvvrdg 301 egstkfvtvn vknalhfeda kiiaesisns mlvktalygq danwgrilca igyaklndlk 361 sldvnkinvs fiatdnsepr elklvangvp qleidetras eilalndlev svdlgtgdqa 421 aqfwtcdlsh eyvtingdyr s // LOCUS NP_013779 239 aa linear PLN 30-JUN-2025 DEFINITION Rim9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013779 VERSION NP_013779.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182561.1 REFERENCE 1 (residues 1 to 239) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 239) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 239) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 239) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 239) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09961. Method: conceptual translation. FEATURES Location/Qualifiers source 1..239 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..239 /product="Rim9p" /calculated_mol_wt="26566" Region 7..169 /region_name="SUR7" /note="SUR7/PalI family; pfam06687" /db_xref="CDD:399580" CDS 1..239 /gene="RIM9" /locus_tag="YMR063W" /coded_by="NM_001182561.1:1..720" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:33002606]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23019326]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:8417990]" /note="Plasma membrane hypothetical protein; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI" /db_xref="GeneID:855085" /db_xref="SGD:S000004667" ORIGIN 1 mvsmihivvf llaittmfei lplitvpvtk ylslssfrnh yyglfgwcvr gqnqelmctk 61 mkigydstdv dssghvltlp snskvvvsnl lvvhpislaf tgtllilavi imvtplgdsp 121 emllftalfs lptfmlcllc flvdillfis kldwpgwlml aatisvalcc smlwvmrrvv 181 svkkyesqqs iahacsmeqy sisdiyqskq ngnsseyeva pthtdsliap evtyrgfie // LOCUS NP_013780 518 aa linear PLN 30-JUN-2025 DEFINITION Aep1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013780 VERSION NP_013780.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182562.1 REFERENCE 1 (residues 1 to 518) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 518) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 518) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 518) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 518) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09962. Method: conceptual translation. FEATURES Location/Qualifiers source 1..518 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..518 /product="Aep1p" /calculated_mol_wt="59617" Region 50..447 /region_name="AEP1" /note="ATPase expression protein 1; pfam17049" /db_xref="CDD:407222" CDS 1..518 /gene="AEP1" /locus_tag="YMR064W" /gene_synonym="NCA1" /coded_by="NM_001182562.1:1..1557" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006417 regulation of translation [PMID:21454598]" /experiment="EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:21454598]" /note="Protein required for expression of the mitochondrial OLI1 gene; mitochondrial OLI1 gene encodes subunit 9 of F1-F0 ATP synthase" /db_xref="GeneID:855086" /db_xref="SGD:S000004668" ORIGIN 1 mittvqeisk wrnlcfirmq srkwypvlkk tplvadgrki ikhadkvphp eeiihpfyqp 61 taieqftaca teynpslldg kkiapslikh pvslktilvd sklkfddirg vnkwlmefva 121 rrqhqrnivl tpasksvrsf hvlhlsstdi aklrglenil seientndlq srvesvnnel 181 qnifdrdskq trlfcenila yliknygnst eklillinvt emqlysrldq mkamniilyn 241 ilckveanen ppysptlvta lenllaainn rffpgrcens lhpivieqll syfiktgnln 301 esknflghli kkgilpeati inryleaidv hfdkstkifd irskfafiad lapiienygt 361 idlfkflipm crhfdelcsl lniirksnna kravdstlpi fikkvltftk dpminsgnls 421 tvfnivspiy gqnvpsefve kfilsfalqg nytmmahmid tykiklshky qlqiiralkn 481 sernhalknt gavgynkefk kyfiekylnc terealrp // LOCUS NP_013781 504 aa linear PLN 30-JUN-2025 DEFINITION Kar5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013781 VERSION NP_013781.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182563.1 REFERENCE 1 (residues 1 to 504) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 504) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 504) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 504) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09963. Method: conceptual translation. FEATURES Location/Qualifiers source 1..504 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..504 /product="Kar5p" /calculated_mol_wt="58309" Region 2..504 /region_name="Tht1" /note="Tht1-like nuclear fusion protein; pfam04163" /db_xref="CDD:282073" CDS 1..504 /gene="KAR5" /locus_tag="YMR065W" /gene_synonym="FIG3" /coded_by="NM_001182563.1:1..1515" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9382856]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:10069807]" /note="Protein required for nuclear membrane fusion during karyogamy; localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; similar to zebrafish Brambleberry protein; expression of the gene is regulated by pheromone" /db_xref="GeneID:855087" /db_xref="SGD:S000004669" ORIGIN 1 mfemryvylf aicikfvsss elgkinnllq grliytdnsv atnvleskfp flkstcvkda 61 lklflpqcia nglesidaet rvetaiklsi cefqasglge ipencmvddl gsmmdcmfel 121 esssqwwtty sgnyqrlssi cyenllpfek eqilklflni telydsfgdd vdtklnhlmf 181 qmeqdsqnfl ddlarmfrny dnelrnates nriilendls ffrnkvndvl yetseqlevq 241 iieknsqlmn evdtvhhims dladelaknd ikskindlkd dslnnlqdlv emsndvkeyy 301 srnnklvnte lenfsmglkk qlggmskdls esqmeaiell qgfnsilhds llpsmtdeiv 361 pemtnfkntl lqewtaitst lngdfalwne eifstfndis eklngtkkkl ddieirvslv 421 hknvmtmmrv ldfmwktskm iircgylavk nkyywllcsv vwiwskyrts rvnvkmipik 481 ryyqwaalll siylgaktgs lidf // LOCUS NP_013782 898 aa linear PLN 30-JUN-2025 DEFINITION Sov1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013782 VERSION NP_013782.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182564.1 REFERENCE 1 (residues 1 to 898) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 898) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 898) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 898) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 898) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09964. Method: conceptual translation. FEATURES Location/Qualifiers source 1..898 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..898 /product="Sov1p" /calculated_mol_wt="104617" CDS 1..898 /gene="SOV1" /locus_tag="YMR066W" /coded_by="NM_001182564.1:1..2697" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008494 translation activator activity [PMID:32449921]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:32449921]" /experiment="EXISTENCE:mutant phenotype:GO:0061668 mitochondrial ribosome assembly [PMID:32449921]" /note="Translational activator involved in mitochondrial translation; role in mitochondrial ribosome assembly" /db_xref="GeneID:855088" /db_xref="SGD:S000004670" ORIGIN 1 mfkynrslcs saliaksqir fyrlkrapln yashipevln ktiigpdepe kclilkgkts 61 eeiennllsn kkfqeinpld tiqetfiqyl kfcnetnfkr snknlnrlkk tleskdsnst 121 vkinavfnyl leecdleikr lnttgqtqvy neekgneddl eqsimndifr saqeqfedqe 181 ghiplrstsf lleilksfne rfngiikpke sitemvtfsq laqafevvkl ipvqemkekg 241 iylvgnllyg tgkvrldpin esfyiesllv fgnykaaysl fitnkdkvne rwwnelglmi 301 tlrsnhlrnf rkllaetdak ystkysylsp rvtklsirky lsignvtean iltdrfiklv 361 eevgiirmkd eqeelptgvk nfqnekhate flneleipsd hdyisivdfh lykrnipmaa 421 qliskymeip gttqedaafl lvktklnmlk dfeklrnifa qnkdyvvpen nvkmlqeafe 481 svitkyntns piynellfen vsaltksivl tdfleefitk qasgqwmeln svsrsrkfng 541 llnillgtge eekaynilkk leeaskkskt dpdllynqfy sevnayhyak fvefyslqiq 601 nmkaqntpsf rkkefkqkvk sllkrmqese vipnavflre ilnfydsmyd fnssfeiinp 661 lleskqqvss esslstsnpc rfynrriitk plyhkiwsvy chyyhvlqnn srilskkssi 721 vkklikrqik ihptchprvl fqmtaengei lpdktfskli vstfmksgdl eaipailtfl 781 tkkfdlnidy dlsmyilkgl krqylrdisn iskdaceykl rkaelmnnes ilknipqgtn 841 qentishlir eilifikwke ksdcstflmv edafkelgte ftlleelied vnklkika // LOCUS NP_013783 416 aa linear PLN 30-JUN-2025 DEFINITION Ubx4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013783 VERSION NP_013783.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182565.1 REFERENCE 1 (residues 1 to 416) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 416) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 416) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 416) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09965. Method: conceptual translation. FEATURES Location/Qualifiers source 1..416 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..416 /product="Ubx4p" /calculated_mol_wt="46834" Region 4..74 /region_name="Ubl_ASPSCR1_like" /note="Ubiquitin-like (Ubl) domain found at the N-terminus of mammalian ASPSCR1 (alveolar soft part sarcoma chromosomal region candidate gene 1 protein), Saccharomyces cerevisie Ubx4p, and similar proteins; cd16105" /db_xref="CDD:340522" Region 277..351 /region_name="UBX" /note="Domain present in ubiquitin-regulatory proteins; smart00166" /db_xref="CDD:197552" CDS 1..416 /gene="UBX4" /locus_tag="YMR067C" /gene_synonym="CUI1" /coded_by="NM_001182565.1:1..1251" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:14755638]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:19359248]" /experiment="EXISTENCE:genetic interaction:GO:0036503 ERAD pathway [PMID:21148305]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:14755638]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:19359248]" /note="UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the role of the Cdc48p-Nplp-Ufd1p AAA ATPase complex in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress; human ortholog ASPSCR1 partially complements the yeast null mutant" /db_xref="GeneID:855089" /db_xref="SGD:S000004671" ORIGIN 1 mpmvtvkynf qlfkckvsln stlndvlhqs iqffqlhtss ndwslihldk pvpldlpwrl 61 lnlptgvnle lskssnfpva nktnredipf ntikirfqip grdsvvkemp sdqpiapilr 121 qmsgaagddf kiqvfskiie fktikdenlt lenlgiqeps svrlifnnts hsegisansa 181 ihpkqtpptm tnpetvaslp phelhkpsvf lpsdeplavi kdqiedeedy eltveqakky 241 qkmlsskagt lggpiltkrl reqsannlpk knkaisecll rvkfpdrshi qiafkpnedm 301 rtvynvvsqf lidenmpftl nqshpfkpla kddkkllddl efgsktmllf etnsnsngpl 361 ikahlledaq kithetrttp svntinksnp qgpsdnatsi kktlnrvpkw mklskk // LOCUS NP_013784 426 aa linear PLN 30-JUN-2025 DEFINITION Avo2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013784 VERSION NP_013784.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182566.1 REFERENCE 1 (residues 1 to 426) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 426) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 426) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 426) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09966. Method: conceptual translation. FEATURES Location/Qualifiers source 1..426 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..426 /product="Avo2p" /calculated_mol_wt="47009" Region <9..185 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 9..37 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 39..72 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 75..106 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(76,80..81,84..86,88..89,93,96,106,108,110,114..115, 118..120,122..123,127,130,139,141,143,147..148,151..153, 155..156,160,163) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 108..139 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 141..165 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..426 /gene="AVO2" /locus_tag="YMR068W" /coded_by="NM_001182566.1:1..1281" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:30969890]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]" /note="Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; TORC2 also regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; PM retention is dependent on Avo3p" /db_xref="GeneID:855090" /db_xref="SGD:S000004672" ORIGIN 1 mlkepsvrlr eaiiegnlli vkrllrrnpd lltnidseng wsslhyasyh grylicvyli 61 qlghdkheli ktfkgntcvh lalmkgheqt lhlllqqfpr finhrgengr apihiacmnd 121 yyqclsllig vgadlwvmdt ngdtplhvcl eygsiscmkm llnegevsld dnvrdkgnwk 181 pidvaqtfev gniyskvlke vkkkgpplga gkkpssfrtp ilnakatfed gpspvlsmns 241 pyslysnnsp lpvlprrist httsgnggnr rssitnpvfn prkptlstds fssssnsssr 301 lrvnsinvkt pvgvspkkel vsesvrhsat ptsphnnial inryllpnks ndnvrgdsqt 361 atinddgggg nggdatigmg lrkdpddene nkykikvnng eprrrvslln ipisklrnsn 421 ntraed // LOCUS NP_013785 285 aa linear PLN 30-JUN-2025 DEFINITION N-terminal L-serine N(alpha)-acetyltransferase NatD [Saccharomyces cerevisiae S288C]. ACCESSION NP_013785 VERSION NP_013785.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182567.1 REFERENCE 1 (residues 1 to 285) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 285) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 285) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 285) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09967. Method: conceptual translation. FEATURES Location/Qualifiers source 1..285 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..285 /product="N-terminal L-serine N(alpha)-acetyltransferase NatD" /EC_number="2.3.1.257" /calculated_mol_wt="32203" Region 180..>245 /region_name="RimI" /note="Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]; COG0456" /db_xref="CDD:440224" CDS 1..285 /gene="NAT4" /locus_tag="YMR069W" /gene_synonym="NAA40" /coded_by="NM_001182567.1:1..858" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010485 histone H4 acetyltransferase activity [PMID:12915400]" /experiment="EXISTENCE:mutant phenotype:GO:0010485 histone H4 acetyltransferase activity [PMID:12915400]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:24068969]" /experiment="EXISTENCE:mutant phenotype:GO:0043998 histone H2A acetyltransferase activity [PMID:12915400]" /note="N alpha-acetyl-transferase; involved in acetylation of the N-terminal residues of histones H4 and H2A" /db_xref="GeneID:855091" /db_xref="SGD:S000004673" ORIGIN 1 mrssvysent yncirtskeh lterrrvama pmfqhflnlc vekfpesieh kdtdgngnft 61 tailereiiy ipeddtdsid svdslkciny klhksrgdqv ldacvqlidk hlgakyrras 121 rimygnrkpw kanklaemks aglvyvcywd ngvlgaftsf mlteetglve gdalhevsvp 181 viylyevhva sahrghgigr rllehalcdg varhtrrmcd nffgvaltvf sdntrarrly 241 ealgfyrapg spapasptir htrhgggrvv vpcdplyyvy clhmp // LOCUS NP_013786 490 aa linear PLN 30-JUN-2025 DEFINITION Mot3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013786 VERSION NP_013786.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182568.1 REFERENCE 1 (residues 1 to 490) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 490) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 490) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 490) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09968. Method: conceptual translation. FEATURES Location/Qualifiers source 1..490 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..490 /product="Mot3p" /calculated_mol_wt="54251" Region 61..>413 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 348..368 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275370" Site order(348,351,364,368) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:275370" Site order(353,355,357,359..360,363..364,367,381,383..385, 387..388,392) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275370" Region 376..394 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275370" CDS 1..490 /gene="MOT3" /locus_tag="YMR070W" /gene_synonym="ROX7" /coded_by="NM_001182568.1:1..1473" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9611199|PMID:10982825]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:23435728]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:22932476|PMID:14562095|PMID:9611199]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:21299653|PMID:10982825|PMID:12145211]" /experiment="EXISTENCE:mutant phenotype:GO:0010895 negative regulation of ergosterol biosynthetic process [PMID:21299653|PMID:12145211]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11292809|PMID:23435728]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14665463]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:23435728]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:21299653]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:16783004]" /note="Transcriptional repressor, activator; role in adjustment to osmotic stress including modulation of mating efficiency; involved in repression of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; relocalizes to cytosol under hypoxia; ethanol stress increases the frequency of [MOT3+] formation, while hypoxia eliminates [MOT3+]" /db_xref="GeneID:855092" /db_xref="SGD:S000004674" ORIGIN 1 mnadhhlqqq qqqrqqhqqq qhqqqqhqhq hqqqqhtilq nvsntnnigs dslasqpfnt 61 ttvssnkddv mvnsgarelp mplhqqqyiy pyyqytsnns nnnnvtagnn msaspivhnn 121 snnsnnsnis asdytvanns tsnnnnnnnn nnnnnnnihp nqftaaanmn snaaaaayys 181 fptanmpipq qdqqymfnpa syishyysav nsnnngnnaa nngsnnsshs apapapgpph 241 hhhhhsnthn nlnnggavnt nnapqhhpti itdqfqfqlq qnpspnlnln inpaqplhlp 301 pgwkintmpq prpttapnhp papvpssnpv asnlvpapss dhkyihqcqf ceksfkrksw 361 lkrhllshsq qrhflcpwcl srqkrkdnll qhmklkhtny lldelkknni ifnynnssss 421 nnnndnnnnn nsnsasgsgg agaaaaaata penedgngyd tniktlindg vlnkddvkrv 481 lnnlivshnk // LOCUS NP_013787 167 aa linear PLN 30-JUN-2025 DEFINITION Tvp18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013787 VERSION NP_013787.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182569.1 REFERENCE 1 (residues 1 to 167) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 167) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 167) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 167) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 167) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09969. Method: conceptual translation. FEATURES Location/Qualifiers source 1..167 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..167 /product="Tvp18p" /calculated_mol_wt="18562" Region 30..141 /region_name="Cg6151-P" /note="Uncharacterized conserved protein CG6151-P; pfam10233" /db_xref="CDD:431157" CDS 1..167 /gene="TVP18" /locus_tag="YMR071C" /coded_by="NM_001182569.1:1..504" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:16107716]" /experiment="EXISTENCE:genetic interaction:GO:0016192 vesicle-mediated transport [PMID:17178117]" /note="Integral membrane protein; localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments; may have a role in intracellular sterol transport" /db_xref="GeneID:855093" /db_xref="SGD:S000004675" ORIGIN 1 malslgqfin vggmvkdlks fnfsvygrwf gyiniilcia lgianlfhvs gviafgiisi 61 iqglvilfie ipfllkicpl sdnfiefikr fetngwrclf ylamaiiqyi siavmatsli 121 vvavgltiss isyavaytkh qefqntniik nptdddfphe avvreml // LOCUS NP_013788 183 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding protein ABF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013788 VERSION NP_013788.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182570.1 REFERENCE 1 (residues 1 to 183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 183) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09970. Method: conceptual translation. FEATURES Location/Qualifiers source 1..183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..183 /product="DNA-binding protein ABF2" /calculated_mol_wt="21431" Region 1..183 /region_name="NHP6B" /note="Chromatin-associated proteins containing the HMG domain [Chromatin structure and dynamics]; COG5648" /db_xref="CDD:227935" CDS 1..183 /gene="ABF2" /locus_tag="YMR072W" /coded_by="NM_001182570.1:1..552" /experiment="EXISTENCE:direct assay:GO:0000262 mitochondrial chromosome [PMID:9581629]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:9581629|PMID:27449618]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:1737790]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10869431|PMID:27371858]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:9581629]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:9581629]" /experiment="EXISTENCE:mutant phenotype:GO:0090139 mitochondrial chromosome packaging [PMID:21282901]" /note="Mitochondrial DNA-binding and packaging factor; mtDNA maintenance factor involved in mitochondrial DNA replication and recombination, regulating mtDNA copy number in opposition to DPI34; HMG1 DNA-binding protein family member containing two HMG-boxes; activity may be regulated by protein kinase A phosphorylation; ABF2 has a paralog, IXR1, that arose from the whole genome duplication; human homolog TFAM can complement yeast abf2 mutant, rescuing the loss-of-mitochondrial DNA phenotype" /db_xref="GeneID:855094" /db_xref="SGD:S000004676" ORIGIN 1 mnsyslltrs fhesskplfn lastllkask rtqlrnelik qgpkrptsay flylqdhrsq 61 fvkenptlrp aeiskiagek wqnleadike kyiserkkly seyqkakkef deklppkkpa 121 gpfikyanev rsqvfaqhpd ksqldlmkii gdkwqsldqs ikdkyiqeyk kaiqeynary 181 pln // LOCUS NP_013789 201 aa linear PLN 30-JUN-2025 DEFINITION Irc21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013789 VERSION NP_013789.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182571.1 REFERENCE 1 (residues 1 to 201) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 201) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 201) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 201) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09971. Method: conceptual translation. FEATURES Location/Qualifiers source 1..201 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..201 /product="Irc21p" /calculated_mol_wt="23051" Region 130..199 /region_name="Cyt-b5" /note="Cytochrome b5-like Heme/Steroid binding domain; pfam00173" /db_xref="CDD:459698" CDS 1..201 /gene="IRC21" /locus_tag="YMR073C" /coded_by="NM_001182571.1:1..606" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:23273983]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:16121259]" /note="hypothetical protein; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study" /db_xref="GeneID:855095" /db_xref="SGD:S000004677" ORIGIN 1 mssdgmnrdv snskpnvrfa apqrlsvahp aissplhmpm skssrkplvr tkirldpghs 61 aldwhsltsn panyytkfvs lqliqdlldd pvfqkdnfkf spsqlknqll vqkiplykim 121 pplrinrkiv kkhckgedel wcvingkvyd issylkfhpg gtdilikhrn sddlityfnk 181 yhqwvnyekl lqvcfigvvc e // LOCUS NP_013790 145 aa linear PLN 30-JUN-2025 DEFINITION Sdd2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013790 VERSION NP_013790.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182572.1 REFERENCE 1 (residues 1 to 145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 145) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09972. Method: conceptual translation. FEATURES Location/Qualifiers source 1..145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..145 /product="Sdd2p" /calculated_mol_wt="15846" Region 8..116 /region_name="dsDNA_bind" /note="Double-stranded DNA-binding domain; pfam01984" /db_xref="CDD:460404" CDS 1..145 /gene="SDD2" /locus_tag="YMR074C" /coded_by="NM_001182572.1:1..438" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:19469552]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:19469552]" /note="Protein with homology to human PDCD5; PDCD5 is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855096" /db_xref="SGD:S000004678" ORIGIN 1 mdpelqaire arlaqlknns ggtngdrnsg anngggensa pvgaaianfl epqalerlsr 61 valvrrdraq avetylkkli atnnvthkit eaeivsilng iakqqnsqnn skiiferkdf 121 sedlnsfdkq nakndddedd ddffd // LOCUS NP_013791 684 aa linear PLN 30-JUN-2025 DEFINITION Rco1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013791 VERSION NP_013791.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182574.1 REFERENCE 1 (residues 1 to 684) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 684) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 684) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 684) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 684) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09973. Method: conceptual translation. FEATURES Location/Qualifiers source 1..684 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..684 /product="Rco1p" /calculated_mol_wt="78706" Region 262..306 /region_name="PHD1_Rco1" /note="PHD finger 1 found in Saccharomyces cerevisiae transcriptional regulatory protein Rco1 and similar proteins; cd15535" /db_xref="CDD:277010" Site order(262,271..275,279,301) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:277010" Region 416..469 /region_name="PHD2_PHF12_Rco1" /note="PHD finger 2 found in PHD finger protein 12 (PHF12), yeast Rco1, and similar proteins; cd15534" /db_xref="CDD:277009" Site order(416,436..440,444,464) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:277009" CDS 1..684 /gene="RCO1" /locus_tag="YMR075W" /coded_by="NM_001182574.1:1..2055" /experiment="EXISTENCE:direct assay:GO:0000118 histone deacetylase complex [PMID:16286008]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032221 Rpd3S complex [PMID:16286007|PMID:16286008]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:19948887]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:19417103]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:24358376]" /experiment="EXISTENCE:mutant phenotype:GO:0060195 negative regulation of antisense RNA transcription [PMID:21248844]" /note="Essential component of the Rpd3S histone deacetylase complex; interacts with Eaf3p" /db_xref="GeneID:855097" /db_xref="SGD:S000004680" ORIGIN 1 mdtskkdttr spshsnsssp sssslsssss kekkrpkrls sqnvnydlkr rkiitsegie 61 rsfknehsnl avednipeee pkellekdsk gniiklneps tisedskvsv tglplnkgps 121 ekikreslwn yrknlggqsn nsemtlvpsk rftqvpknfq dlnrndlktf ltenmteesn 181 irstigwngd iinrtrdrep esdrdnkkls nirtkiilst natydskskl fgqnsiksts 241 nasekifrdk nnstidfene dfcsacnqsg sflccdtcpk sfhflcldpp idpnnlpkgd 301 whcneckfki finnsmatlk kiesnfikqn nnvkifakll fnidshnpkq fqlpnyiket 361 fpavktgsrg qysdendkip ltdrqlfnts ygqsitklds ynpdthidsn sgkflicykc 421 nqtrlgswsh pensrlimtc dycqtpwhld cvprasfknl gskwkcplhs ptkvykkihh 481 cqednsvnyk vwkkqrlink knqlyyeplq kigyqnngni qiipttshtd ydfnqdfkit 541 qidensikyd ffdkiykskm vqkrklfqfq eslidklvsn gsqngnsedn mvkdiasliy 601 fqvsnndkss nnksasksnn lrklwdlkel tnvvvpneld siqfndfssd eikhllylkk 661 iieskpkeel lkflnienpe nqse // LOCUS NP_001381970 121 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR075C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381970 VERSION NP_001381970.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395040.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54811. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..121 /product="uncharacterized protein" /calculated_mol_wt="13902" CDS 1..121 /locus_tag="YMR075C-A" /coded_by="NM_001395040.1:1..366" /note="hypothetical protein; almost completely overlaps verified ORF RCO1/YMR075W" /db_xref="GeneID:855098" /db_xref="SGD:S000004679" ORIGIN 1 myvrrfysdw fsgfsmfknf nsssfgldsi iffkynrcfi sslekslnci esssfgtttl 61 vssfkshnfl klllleadll llllsllltw kyikeamslt ilssllpfwd pfdtnlsikl 121 s // LOCUS NP_013793 1277 aa linear PLN 30-JUN-2025 DEFINITION sister chromatid cohesion factor PDS5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013793 VERSION NP_013793.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182575.1 REFERENCE 1 (residues 1 to 1277) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1277) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1277) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1277) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09974. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1277 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1277 /product="sister chromatid cohesion factor PDS5" /calculated_mol_wt="146911" Region 26..1148 /region_name="PDS5" /note="Sister chromatid cohesion protein PDS5 protein; pfam20168" /db_xref="CDD:466319" Site order(256..257,260,263..264,297..298,301,304..305,308, 339..340,343,346..347,376..377,380,383..384,416..417,420, 423..424) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 276..308 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 321..349 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 358..384 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 396..425 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..1277 /gene="PDS5" /locus_tag="YMR076C" /coded_by="NM_001182575.1:1..3834" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:11062262]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0035808 meiotic recombination initiation complex [PMID:31617566]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:11137006]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:11448778|PMID:19736318]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:11062262|PMID:14623866]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:11062262]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:19736318]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:35102525]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:31617566]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:15819623]" /experiment="EXISTENCE:mutant phenotype:GO:0140588 chromatin looping [PMID:32032532]" /note="Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; regulates homolog pairing and facilitates synaptonemal complex formation, axis formation, interhomolog recombination and synapsis during meiosis; relocalizes to the cytosol in response to hypoxia; scaffolding protein contains 26 HEAT repeats" /db_xref="GeneID:855099" /db_xref="SGD:S000004681" ORIGIN 1 makgavtklk fnspiistsd qlistnelld rlkalheela sldqdntdlt gldkyrdalv 61 srkllkhkdv giraftaccl sdilrlyapd apytdaqltd ifklvlsqfe qlgdqengyh 121 iqqtylitkl leyrsivlla dlpssnnlli elfhifydpn ksfparlfnv iggilgevis 181 efdsvplevl rlifnkflty npneipegln vtsdcgyevs lilcdtysnr msrhltkyys 241 eiiheatndd nnsrlltvvv klhklvlrlw etvpelinav igfiyhelss enelfrkeat 301 kligqiltsy sdlnfvsths dtfkawiski adispdvrve wtesipqiia trediskeln 361 qalaktfids dprvrrtsvm ifnkvpvtei wknitnkaiy tsllhlarek hkevrelcin 421 tmakfysnsl neiertyqnk eiweiidtip stlynlyyin dlnineqvds vifeyllpfe 481 pdndkrvhrl ltvlshfdkk aftsffafna rqikisfais kyidfskfln nqesmsssqg 541 pivmnkynqt lqwlasglsd stkaidalet ikqfnderif yllnacvtnd ipfltfkncy 601 nelvsklqtp glfkkynist gasimprdia kviqillfra spiiynvsni svllnlsnns 661 dakqldlkrr ilddiskvnp tlfkdqirtl ktiikdlddp daekndnlsl eealktlyka 721 sktlkdqvdf ddtffftkly dfaveskpei tkyatklial spkaeetlkk ikirilpldl 781 qkdkyftshi ivlmeifkkf phvlnddstd iisylikevl lsnqvvgdsk keidwvedsl 841 lsdtkysaig nkvftlklft nklrsiapdv prdelaesft ektmklffyl iasggelise 901 fnkefyptps nyqtklrcva giqvlklari snlnnfikps diiklinlve deslpvrktf 961 leqlkdyvan elisikflpl vfftayepdv elktttkiwi nftfglksfk kgtiferalp 1021 rlihaiahhp divggldseg daylnaltta idyllfyfds iaaqenfsll yylservkny 1081 qdklvedeid eeegpqkeea pkkhrpygqk myiigelsqm illnlkekkn wqhsaypgkl 1141 nlpsdlfkpf atvqeaqlsf ktyipeslte kiqnnikaki grilhtsqtq rqrlqkrlla 1201 hennesqkkk kkvhharsqa ddeegdgdre sdsdddsysp snknetkkgh enivmkklrv 1261 rkevdykdde dddiemt // LOCUS NP_013794 221 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-III subunit protein VPS20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013794 VERSION NP_013794.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182576.1 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09975. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..221 /product="ESCRT-III subunit protein VPS20" /calculated_mol_wt="25507" Region 15..186 /region_name="Snf7" /note="pfam03357" /db_xref="CDD:460896" CDS 1..221 /gene="VPS20" /locus_tag="YMR077C" /gene_synonym="CHM6; VPL10; VPT20" /coded_by="NM_001182576.1:1..666" /experiment="EXISTENCE:direct assay:GO:0000815 ESCRT III complex [PMID:12194857]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12194857]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:31273031]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:29588378|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0070676 intralumenal vesicle formation [PMID:23444383]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:29588378]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12953057]" /experiment="EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:19234443]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15086794]" /note="Myristoylated subunit of the ESCRT-III complex; the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes" /db_xref="GeneID:855101" /db_xref="SGD:S000004682" ORIGIN 1 mgqksskvhi tktdrailev krskdeihkf trrtdnlilv eksqlkdlir knpenyksnm 61 kvrfllkrih yqehllqqas dqlinlenmv stlefkmvek qfinglkngn eilkklnkef 121 snvdelmddv qdqiayqnei netlsrslvg tsnyeddldk eldaleseln pekmnnakva 181 nmpsteglps lpqgeqteqk ereefateer sdtkeplall s // LOCUS NP_013795 741 aa linear PLN 30-JUN-2025 DEFINITION Ctf18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013795 VERSION NP_013795.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182577.1 REFERENCE 1 (residues 1 to 741) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 741) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 741) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 741) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 741) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 741) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 741) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09976. Method: conceptual translation. FEATURES Location/Qualifiers source 1..741 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..741 /product="Ctf18p" /calculated_mol_wt="84243" Region 116..>422 /region_name="PRK04195" /note="replication factor C large subunit; Provisional" /db_xref="CDD:235250" CDS 1..741 /gene="CTF18" /locus_tag="YMR078C" /gene_synonym="CHL12" /coded_by="NM_001182577.1:1..2226" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16962805]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:17483413]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:17636314]" /experiment="EXISTENCE:mutant phenotype:GO:0003689 DNA clamp loader activity [PMID:32277910]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:20980819]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:11389843|PMID:11287619]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:16525505]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:21347277]" /experiment="EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]" /note="Subunit of a complex with Ctf8p; shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint" /db_xref="GeneID:855102" /db_xref="SGD:S000004683" ORIGIN 1 mvdtapyigs lgrsslfdtg dieqapgnna igineediha fvsstgetvq lkkkpaklat 61 gnislytnpd tvwrsddtyg ininylldki easgddrtna qktspitgki gsdtlwvekw 121 rpkkfldlvg nektnrrmlg wlrqwtpavf keqlpklpte kevsdmeldp lkrppkkill 181 lhgppgigkt svahviakqs gfsvseinas deragpmvke kiynllfnht fdtnpvclva 241 deidgsiesg firilvdimq sdikatnkll ygqpdkkdkk rkkkrskllt rpiicicnnl 301 yapsleklkp fceiiavkrp sdttllerln lichkenmni pikaindlid laqgdvrnci 361 nnlqflasnv dsrdssasdk pacakntwas snkdspiswf kivnqlfrkd phrdikeqfy 421 ellnqvelng nsdrilqgcf nifpyvkysd ngirkpanis dwlffhdlmy qsmyahngel 481 lrysalvplv ffqtfgdian kddirmknse yeqrelkran sdivslimrh isvqsplmas 541 ftdrkslife ilpyldsmis sdfnkirnlk lkqaimeelv qllksfqlnl iqnrsegfdv 601 rggltidppi devvllnpkh inevqhkran nlssllakie enrakkrhid qvtedrlqsq 661 emhskkvktg lnsssstidf fknqygllkq tqeleetqkt igsdetnqad dcnqtvkiwv 721 kynegfsnav rknvtwnnlw e // LOCUS NP_013796 304 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol/phosphatidylcholine transfer protein SEC14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013796 VERSION NP_013796.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182578.1 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09977. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..304 /product="phosphatidylinositol/phosphatidylcholine transfer protein SEC14" /calculated_mol_wt="34770" Region 34..79 /region_name="CRAL_TRIO_N" /note="CRAL/TRIO, N-terminal domain; smart01100" /db_xref="CDD:215024" Region 99..269 /region_name="SEC14" /note="Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p); smart00516" /db_xref="CDD:214706" CDS 1..304 /gene="SEC14" /locus_tag="YMR079W" /gene_synonym="PIT1" /coded_by="NM_001182578.1:1..915" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:7816798]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:1997207]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:1997207]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:2466847|PMID:12869188|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008525 phosphatidylcholine transporter activity [PMID:10488334|PMID:2407740|PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10848624|PMID:2215682|PMID:2407740]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10848624|PMID:2215682|PMID:2407740]" /experiment="EXISTENCE:direct assay:GO:0048194 Golgi vesicle budding [PMID:9553090|PMID:9736710]" /experiment="EXISTENCE:direct assay:GO:2001246 negative regulation of phosphatidylcholine biosynthetic process [PMID:7816798]" /experiment="EXISTENCE:genetic interaction:GO:0006896 Golgi to vacuole transport [PMID:18753406]" /experiment="EXISTENCE:genetic interaction:GO:0046488 phosphatidylinositol metabolic process [PMID:10567405]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:18753406]" /experiment="EXISTENCE:mutant phenotype:GO:0008525 phosphatidylcholine transporter activity [PMID:10488334]" /experiment="EXISTENCE:mutant phenotype:GO:0008526 phosphatidylinositol transfer activity [PMID:2215682|PMID:10848624]" /experiment="EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:2215682]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:14528019]" /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:10848624|PMID:19129178|PMID:6754086]" /experiment="EXISTENCE:mutant phenotype:GO:0046488 phosphatidylinositol metabolic process [PMID:10567405]" /experiment="EXISTENCE:mutant phenotype:GO:1901352 negative regulation of phosphatidylglycerol biosynthetic process [PMID:12869188]" /experiment="EXISTENCE:mutant phenotype:GO:2001246 negative regulation of phosphatidylcholine biosynthetic process [PMID:7816798]" /note="Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs; SEC14 has a paralog, YKL091C, that arose from the whole genome duplication" /db_xref="GeneID:855103" /db_xref="SGD:S000004684" ORIGIN 1 mvtqqekefl esypqncppd alpgtpgnld saqekalael rklledagfi erlddstllr 61 flrarkfdvq lakemfence kwrkdygtdt ilqdfhydek pliakfypqy yhktdkdgrp 121 vyfeelgavn lhemnkvtse ermlknlvwe yesvvqyrlp acsraaghlv etsctimdlk 181 gisissaysv msyvreasyi sqnyypermg kfyiinapfg fstafrlfkp fldpvtvski 241 filgssyqke llkqipaenl pvkfggksev deskgglyls digpwrdpky igpegeapea 301 fsmk // LOCUS NP_013797 971 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase NAM7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013797 VERSION NP_013797.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182579.1 REFERENCE 1 (residues 1 to 971) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 971) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 971) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 971) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09978. Method: conceptual translation. FEATURES Location/Qualifiers source 1..971 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..971 /product="ATP-dependent RNA helicase NAM7" /EC_number="3.6.4.12" /EC_number="3.6.4.13" /calculated_mol_wt="109300" Region 61..208 /region_name="UPF1_Zn_bind" /note="RNA helicase (UPF2 interacting domain); pfam09416" /db_xref="CDD:401391" Region 260..352 /region_name="UPF1_1B_dom" /note="RNA helicase UPF1, 1B domain; pfam18141" /db_xref="CDD:407973" Region 357..836 /region_name="TIGR00376" /note="DNA helicase, putative" /db_xref="CDD:273041" Region 408..639 /region_name="DEXXQc_UPF1" /note="DEXXQ-box helicase domain of UPF1; cd18039" /db_xref="CDD:350797" Site order(408..410,413,432..438,601,638..639) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350797" Site order(460..462,484..487,537,553,555,605,607) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:350797" CDS 1..971 /gene="NAM7" /locus_tag="YMR080C" /gene_synonym="IFS2; MOF4; SUP113; SUT2; UPF1" /coded_by="NM_001182579.1:1..2916" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:8816462]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:18676617]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:8816461|PMID:8816462]" /experiment="EXISTENCE:direct assay:GO:0043024 ribosomal small subunit binding [PMID:23801788]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16157874]" /experiment="EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429|PMID:12769863]" /experiment="EXISTENCE:mutant phenotype:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:8816461|PMID:8816462]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:16285926]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0006449 regulation of translational termination [PMID:8816461]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:16777600]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:18676617]" /experiment="EXISTENCE:mutant phenotype:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:physical interaction:GO:0016567 protein ubiquitination [PMID:18676617]" /note="ATP-dependent RNA helicase of the SFI superfamily; involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; binds to the small ribosomal subunit via an interaction with Rps26; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:855104" /db_xref="SGD:S000004685" ORIGIN 1 mvgsgshtpy disnspsdvn vqpatqlnst lvedddvdnq lfeeaqvtet gfrspsasdn 61 scaycgidsa kcvikcnsck kwfcntkngt ssshivnhlv lshhnvvslh pdsdlgdtvl 121 ecyncgrknv fllgfvsaks eavvvllcri pcaqtknanw dtdqwqplie drqllswvae 181 qpteeeklka rlitpsqisk leakwrsnkd atindidape eqeaipplll ryqdayeyqr 241 sygpliklea dydkqlkesq alehisvsws lalnnrhlas ftlstfesne lkvaigdemi 301 lwysgmqhpd wegrgyivrl pnsfqdtftl elkpsktppp thlttgftae fiwkgtsydr 361 mqdalkkfai dkksisgyly ykilghqvvd isfdvplpke fsipnfaqln ssqsnavshv 421 lqrplsliqg ppgtgktvts ativyhlski hkdrilvcap snvavdhlaa klrdlglkvv 481 rltaksredv essvsnlalh nlvgrgakge lknllklkde vgelsasdtk rfvklvrkte 541 aeilnkadvv cctcvgagdk rldtkfrtvl idestqasep eclipivkga kqvilvgdhq 601 qlgpvilerk aadaglkqsl ferlislghv pirlevqyrm npylsefpsn mfyegslqng 661 vtieqrtvpn skfpwpirgi pmmfwanygr eeisangtsf lnrieamnce riitklfrdg 721 vkpeqigvit pyegqrayil qymqmngsld kdlyikveva svdafqgrek dyiilscvra 781 neqqaigflr dprrlnvglt rakyglvilg nprslarntl wnhllihfre kgclvegtld 841 nlqlctvqlv rpqprkterp mnaqfnvese mgdfpkfqdf daqsmvsfsg qigdfgnafv 901 dntelssyin neywnfenfk safsqkqnrn eiddrnlyqe eashlnsnfa relqreeqkh 961 elskdfsnlg i // LOCUS NP_013798 338 aa linear PLN 30-JUN-2025 DEFINITION Isf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013798 VERSION NP_013798.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182580.1 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09979. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..338 /product="Isf1p" /calculated_mol_wt="36979" Region 6..178 /region_name="MBR1" /note="Mitochondrial biogenesis regulation protein 1; pfam17058" /db_xref="CDD:435712" CDS 1..338 /gene="ISF1" /locus_tag="YMR081C" /gene_synonym="MBR3" /coded_by="NM_001182580.1:1..1017" /experiment="EXISTENCE:genetic interaction:GO:0009060 aerobic respiration [PMID:8208248]" /note="Serine-rich, hydrophilic protein; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant; ISF1 has a paralog, MBR1, that arose from the whole genome duplication" /db_xref="GeneID:855105" /db_xref="SGD:S000004686" ORIGIN 1 miaseiferg vqdpfcqdcd yedetdvqsf lgsndlndfv nsklasfsfq nssksnnshh 61 ssstnagnts rhignhtigh hlrkiktaph hlygfvpans tnnsnepirp sprriranss 121 tlihqlsrqs trqsslgdaa dscfdhkcik prsrhsscyg ipthlyglek yvsseldsla 181 vandqsndlt spltsvstpa snsnsylnln sssaaypssy lsneknnrlk lishgkissn 241 nvpghsgnln hyhrertpsn lrresfslls ngssssplqt rnnsysnslv kspsnsslnt 301 svassneess phtsncleer nprrksfikl slassfsn // LOCUS NP_001335805 118 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR082C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335805 VERSION NP_001335805.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348865.1 REFERENCE 1 (residues 1 to 118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 118) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80325. Method: conceptual translation. FEATURES Location/Qualifiers source 1..118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..118 /product="uncharacterized protein" /calculated_mol_wt="13958" CDS 1..118 /locus_tag="YMR082C" /coded_by="NM_001348865.1:1..357" /note="hypothetical protein; conserved among S. cerevisiae strains; YMR082C is not an essential gene" /db_xref="GeneID:855106" /db_xref="SGD:S000004687" ORIGIN 1 mtiaeitirq kfsypflfgn vlghpwprnv prkeikmllf rtannsfpgf lliftrkrrn 61 lpkqrdneip rtraletylr vfsaarkqre adatasfwrl vtsasrshyh mwpikrii // LOCUS NP_013800 375 aa linear PLN 30-JUN-2025 DEFINITION alcohol dehydrogenase ADH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013800 VERSION NP_013800.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182582.1 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09980. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..375 /product="alcohol dehydrogenase ADH3" /EC_number="1.1.1.1" /calculated_mol_wt="40239" Region 34..372 /region_name="CAD3" /note="Cinnamyl alcohol dehydrogenases (CAD); cd08297" /db_xref="CDD:176257" Site order(71..73,76,181,185,205,207..208,210,228..229,234, 273..276,279,296..298,321..323,368) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:176257" Site order(71,73,82,94,120,181,298,323) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:176257" Site order(71,94,181) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176257" Site order(82,127,129..130,138..140,196..198,220..222,224,236, 239..240,280,288,290,295,297..298,308..309,314..322, 326..327,331,335,338) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:176257" Site order(125,128,131,139) /site_type="other" /note="structural Zn binding site [ion binding]" /db_xref="CDD:176257" CDS 1..375 /gene="ADH3" /locus_tag="YMR083W" /coded_by="NM_001182582.1:1..1128" /experiment="EXISTENCE:direct assay:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:3550419]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:3550419]" /experiment="EXISTENCE:genetic interaction:GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /note="Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production" /db_xref="GeneID:855107" /db_xref="SGD:S000004688" ORIGIN 1 mlrtstlftr rvqpslfsrn ilrlqstaai pktqkgvify enkgklhykd ipvpepkpne 61 ilinvkysgv chtdlhawhg dwplpvklpl vgghegagvv vklgsnvkgw kvgdlagikw 121 lngscmtcef cesghesncp dadlsgythd gsfqqfatad aiqaakiqqg tdlaevapil 181 cagvtvykal keadlkagdw vaisgaaggl gslavqyata mgyrvlgida geekeklfkk 241 lggevfidft ktknmvsdiq eatkggphgv invsvseaai slsteyvrpc gtvvlvglpa 301 nayvksevfs hvvksinikg syvgnradtr ealdffsrgl ikspikivgl selpkvydlm 361 ekgkilgryv vdtsk // LOCUS NP_013801 262 aa linear PLN 30-JUN-2025 DEFINITION putative glutamine--fructose-6-phosphate transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013801 VERSION NP_013801.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182583.1 REFERENCE 1 (residues 1 to 262) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 262) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 262) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 262) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 262) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 262) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 262) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09981. Method: conceptual translation. FEATURES Location/Qualifiers source 1..262 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..262 /product="putative glutamine--fructose-6-phosphate transaminase" /EC_number="2.6.1.16" /calculated_mol_wt="29141" Region 2..206 /region_name="GFAT" /note="Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; cd00714" /db_xref="CDD:238366" Site order(2,33,87..88,90..91,100,115..116,140..141) /site_type="active" /note="glutaminase active site [active]" /db_xref="CDD:238366" CDS 1..262 /locus_tag="YMR084W" /coded_by="NM_001182583.1:1..789" /note="hypothetical protein; YMR084W and adjacent ORF YMR085W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1" /db_xref="GeneID:855108" /db_xref="SGD:S000004689" ORIGIN 1 mcgifgycnf liektrgeii dtlieglqal eykeydssgi siqgdelesl niykqtgkis 61 slkeeidlyn lnknlpfish cgiahtrrat hgglrranch phnsdpsnef vvvhngvitn 121 fanlkallma kgyvfksdtd tecipklykh iydtsielgy nldfhvltnl vlkelegsyg 181 llctsshfpd evvaarkgsp lvigvkgktd mdvnfvevey ldqeedylkl ntqtkssgnv 241 laaapvkynt clrksppfvh nt // LOCUS NP_013802 432 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR085W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013802 VERSION NP_013802.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182584.1 REFERENCE 1 (residues 1 to 432) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 432) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 432) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 432) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09982. Method: conceptual translation. FEATURES Location/Qualifiers source 1..432 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..432 /product="uncharacterized protein" /calculated_mol_wt="48371" Region <1..428 /region_name="PLN02981" /note="glucosamine:fructose-6-phosphate aminotransferase" /db_xref="CDD:215531" CDS 1..432 /locus_tag="YMR085W" /coded_by="NM_001182584.1:1..1299" /note="hypothetical protein; YMR085W and adjacent ORF YMR084W are merged in related strains, and together are paralogous to glutamine-fructose-6-phosphate amidotransferase GFA1" /db_xref="GeneID:855109" /db_xref="SGD:S000004690" ORIGIN 1 mefylssdca slaryvskvv yledndiahi ydgelhihcs kigsedfsfr tvqklelels 61 kikkgpydnf mqkeiyeqce ttknvmrgrv daftnrvvlg glenwltelr rakriimias 121 kasfhsclaa rpifeelmev pvnvelaldf vdrnccifrn dvcifvsrsg ettdtinaln 181 ycikkeavti gvvncsgssi srfthcgvht ntgpekgiat tksytsqyia lvmialwmse 241 dlvskierrk eiiqaltivp sqikevlele pliielcdkk lkqhdtflll grgyqfasal 301 egaskmkeis yvhsesiltn elghrvlava sdnppiiafa tkdafspkia scidqiierk 361 gnpiiicnkg hkiweqdkqk gnvvtlevpq tvdclqgiln viplqlisyw laikkdigvd 421 lprdsamsap di // LOCUS NP_013803 960 aa linear PLN 30-JUN-2025 DEFINITION Seg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013803 VERSION NP_013803.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182586.1 REFERENCE 1 (residues 1 to 960) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 960) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 960) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 960) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 960) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 960) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 960) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09983. Method: conceptual translation. FEATURES Location/Qualifiers source 1..960 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..960 /product="Seg1p" /calculated_mol_wt="105743" Region <215..541 /region_name="PTZ00341" /note="Ring-infected erythrocyte surface antigen; Provisional" /db_xref="CDD:173534" CDS 1..960 /gene="SEG1" /locus_tag="YMR086W" /coded_by="NM_001182586.1:1..2883" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:22869600|PMID:19269952]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0070941 eisosome assembly [PMID:22869600]" /note="Component of eisosome required for proper eisosome assembly; precedes Pil1p/Lsp1p during eisosome formation, controls eisosome length and shape; diffusely distributed, forms heterogeneous patches at plasma membrane in small buds, also found in medium and large buds; expression repressed by cAMP; similar to A. gossypii SEG gene and to S. pombe Sle1p, important for generating eisosomes; SEG1 has a paralog, SEG2, that arose from the whole genome duplication" /db_xref="GeneID:855110" /db_xref="SGD:S000004692" ORIGIN 1 mfrrrttape meqadptava aaasigkllm kkgnqsdneq rptyrsasmt nlrkpsapkr 61 mssississe srrsdgkgrp gkinsltqrs smgkgdslns pltkepqhkt rshnrtsslp 121 nqrgqqsrns sglqrqkskt hqrisydeaq rtfkdfggpq argiltgqhr tenpsgsipl 181 rttrkyipgp nglvaievpv ekpsnantsk llrrsnsahs alnarngsll rkkvsqeslh 241 sqpkktsslg ntsstqakkg qkavqernla kkhpinsnvp lietqvreet dqelkldnsn 301 ssesetvvns ennlekpssl niekddlskl ihenielesf ieekgkekpl nsdqedvfis 361 ektvkgdvqw pknnrqastl ektfnydnee kregnkpvae hplpeaevdd ksveqlnnis 421 ssgsysaqgs venskpengn knlendttss ptqdldeksr sieekdtleg tesskkvekp 481 dnccekisga ntsskkgnvg dtkdeffdtv eesdqktsks nsskntdhsn qteptpslaq 541 ylrtsntyls rknqskqaeq ekfhkpeapm vpvtkvvtpi ksalkkssgs snhdssmysd 601 nspangayls lttaentrln aqmtmsdsvs rraslkrssi krpqsvgqfr sirsnspspp 661 ekinnkrhsa iplgtpekgk pkrnsvmasl sknsqqiqep asvyesngpn kpknqinkni 721 krgsqiaqnn kpstkdmnsi lypkeppprk ssfektrsne shlgfkklsl rngnfeeals 781 esyngqasqn stnvnrtdta qeffkylghs srfadsdsed esqffnqgps kyntetegnk 841 tsgnknsngg ngafslfksk skqkennvvs pgvsspnhtt tdpaitskkv dkkfsglslr 901 aaseaepakn snpsmtnrlr fssnpenges rlpqaqevsv tkekkgsfgk klkkifgrkk // LOCUS NP_013805 284 aa linear PLN 30-JUN-2025 DEFINITION putative ADP-ribose 1''-phosphate phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013805 VERSION NP_013805.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182587.1 REFERENCE 1 (residues 1 to 284) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 284) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 284) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 284) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09984. Method: conceptual translation. FEATURES Location/Qualifiers source 1..284 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..284 /product="putative ADP-ribose 1''-phosphate phosphatase" /EC_number="3.1.3.84" /calculated_mol_wt="31936" Region 1..280 /region_name="Macro_SF" /note="macrodomain superfamily; cl00019" /db_xref="CDD:469581" Site order(23,53..55,78..80,87..90,148..149,192,194..198) /site_type="other" /note="ADP-ribose binding site [chemical binding]" /db_xref="CDD:394872" Site order(80,82,84,107,111,114,116..118,150..152,168,171..172, 175..176) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:394872" CDS 1..284 /gene="PDL32" /locus_tag="YMR087W" /coded_by="NM_001182587.1:1..855" /note="Putative ADP-ribose-1''-monophosphatase; converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain" /db_xref="GeneID:855112" /db_xref="SGD:S000004693" ORIGIN 1 mtgslnrhsl lngvkkmrii lcdtnevvtn lwqesiphay iqndkylcih hghlqslmds 61 mrkgdaihhg hsyaivspgn sygylgggfd kalynyfggk pfetwfrnql ggryhtvgsa 121 tvvdlqrcle ektiecrdgi ryiihvptvv apsapifnpq nplktgfepv fnamwnalmh 181 spkdidglii pglctgyagv ppiiscksma falrlymagd hiskelknvl imyylqypfe 241 pffpesckie cqklgidiem lksfnvekda ielliprril tldl // LOCUS NP_013806 562 aa linear PLN 30-JUN-2025 DEFINITION Vba1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013806 VERSION NP_013806.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182588.1 REFERENCE 1 (residues 1 to 562) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 562) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 562) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 562) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09985. Method: conceptual translation. FEATURES Location/Qualifiers source 1..562 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..562 /product="Vba1p" /calculated_mol_wt="62509" Region 42..469 /region_name="MFS_Azr1_MDR_like" /note="Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17502" /db_xref="CDD:341045" Site order(49..50,53..54,57,88,138..139,141..143,146,166, 169..170,173,301,304..305,308..310,313,341,345,424..425, 429,433,449,452..453,456..457,460) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:341045" CDS 1..562 /gene="VBA1" /locus_tag="YMR088C" /coded_by="NM_001182588.1:1..1689" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:15572352]" /experiment="EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:15572352]" /experiment="EXISTENCE:mutant phenotype:GO:0015174 basic amino acid transmembrane transporter activity [PMID:15572352]" /experiment="EXISTENCE:mutant phenotype:GO:0015802 basic amino acid transport [PMID:15572352]" /note="Permease of basic amino acids in vacuolar membrane; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:855113" /db_xref="SGD:S000004694" ORIGIN 1 mqtldetsnl lpppeeaeap pleqkfheyn lalpkfpilf slwlgsflss ldstivanim 61 nrvaeefses skkqwiatsf lltntafqpl ygklsditgr ksalltaqff fglgclltcf 121 arnvtefsia raicgigagg lnaissiavs dictarergv yqgyanivfg fgqllgaplg 181 gvfietigwr alfgiqvpvi mlcsvlaikn iniklfhvpp mkerytlknl sridifgsls 241 lvatisgvlf lcssqlnkly lalftigsfi vfilveryya tekilpfell trsfclssav 301 tvissfvvfg eifrspiylq llqnisvtkt glflifpsis vavgslvtgw vlrntkinla 361 hcayqiifgg mimqllglgl gyfllshlnp dytiydmles itfrsnsiww kliyvfasvl 421 vsfgyacllv atlvsivftv eksqqgtmtg vfylwrsign vlgasltlvs yenslssmlw 481 nymfktkrdd eyhftkkqyy slindssylr gpnfptdifv rildvykkaf lisyipnial 541 aavgivlsly lvkhtykrss ss // LOCUS NP_013807 825 aa linear PLN 30-JUN-2025 DEFINITION m-AAA protease subunit YTA12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013807 VERSION NP_013807.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182589.1 REFERENCE 1 (residues 1 to 825) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 825) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 825) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 825) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09986. Method: conceptual translation. FEATURES Location/Qualifiers source 1..825 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..825 /product="m-AAA protease subunit YTA12" /calculated_mol_wt="93146" Region <205..282 /region_name="FtsH_ext" /note="FtsH Extracellular; pfam06480" /db_xref="CDD:377663" Region 290..784 /region_name="FtsH_fam" /note="ATP-dependent metalloprotease FtsH; TIGR01241" /db_xref="CDD:273520" CDS 1..825 /gene="YTA12" /locus_tag="YMR089C" /gene_synonym="RCA1" /coded_by="NM_001182589.1:1..2478" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:19748354]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:11914276|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7929327]" /experiment="EXISTENCE:direct assay:GO:0005745 m-AAA complex [PMID:8681382]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:19748354]" /experiment="EXISTENCE:direct assay:GO:0097002 mitochondrial inner boundary membrane [PMID:19019989]" /experiment="EXISTENCE:mutant phenotype:GO:0006465 signal peptide processing [PMID:12417197]" /experiment="EXISTENCE:mutant phenotype:GO:0008237 metallopeptidase activity [PMID:8681382]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:19748354]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:8681382]" /note="Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; overexpression of human AFG3L2 complements respiratory defect of yeast afg3 yta12 double null mutation, but overexpression of disease-associated AFG3L2 variants does not; expression of both human SPG7 (paraplegin) and AFG3L2 complements yeast yta12 afg3 double mutation" /db_xref="GeneID:855114" /db_xref="SGD:S000004695" ORIGIN 1 mlllswsria tkvvrrpvrf rsyyglthik slhtqyrlln rlqenksgnk nednnedakl 61 nkeiptdeev eairkqveky ieqtknntip anwkeqkrki desirrleda vlkqesnriq 121 eerkekeeen gpskaksnrt keqgyfegnn srnipppppp pppkpplndp snpvsknvnl 181 fqigltffll sflldllnsl eeqseitwqd frekllakgy vaklivvnks mvkvmlndng 241 knqadnygrn fyyftigsid sfehklqkaq deldidkdfr ipvlyvqegn wakamfqilp 301 tvlmiagiiw ltrrsaqaag gsrggifgls rskakkfnte tdvkikfkdv agcdeakeei 361 mefvsflkep sryekmgaki prgailsgpp gtgktllaka tageagvpfy fvsgsefvem 421 fvgvgaarvr dlfktarena psivfideid aigkarqkgn fsganderen tlnqmlvemd 481 gftpadhvvv lagtnrpdil dkallrpgrf drhinidkpe legrkaifav hlhhlklage 541 ifdlknrlaa ltpgfsgadi anvcneaali aarsdedavk lnhfeqaier viggverksk 601 llspeekkvv ayheaghavc gwylkyadpl lkvsiiprgq galgyaqylp gdifllteqq 661 lkdrmtmslg grvseelhfp svtsgasddf kkvtsmatam vtelgmsdki gwvnyqkrdd 721 sdltkpfsde tgdiidsevy rivqechdrc tkllkekaed vekiaqvllk kevltredmi 781 dllgkrpfpe rndafdkyln dyetekirke eeknekrnep kpstn // LOCUS NP_013808 227 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR090W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013808 VERSION NP_013808.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182590.1 REFERENCE 1 (residues 1 to 227) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 227) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 227) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 227) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09987. Method: conceptual translation. FEATURES Location/Qualifiers source 1..227 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..227 /product="uncharacterized protein" /calculated_mol_wt="24751" Region 5..217 /region_name="SDR_a5" /note="atypical (a) SDRs, subgroup 5; cd05243" /db_xref="CDD:187554" Site order(10,12..15,37,57..58,80..81,93,117..118,140,159..162) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:187554" Site order(94,118,136,140) /site_type="active" /note="putative active site [active]" /db_xref="CDD:187554" CDS 1..227 /locus_tag="YMR090W" /coded_by="NM_001182590.1:1..684" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; similar to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability" /db_xref="GeneID:855115" /db_xref="SGD:S000004696" ORIGIN 1 mspmkvavvg asgkvgrlli nqlkandsfs tplaivrtqd qvnyfknevg vdasltdien 61 asvseitdai kaydavvfsa gaggkgmeri ftvdldgcik vveacekagi krfvvvsalk 121 aedrdfwyni kglreyyiak rsadrevrns nldytilqpg slelnkgtgl lqpldkleek 181 asvnysinre dvasfivesl lhpnatvkkt islvngnepm ekfiqsl // LOCUS NP_013809 435 aa linear PLN 30-JUN-2025 DEFINITION Npl6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013809 VERSION NP_013809.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182591.1 REFERENCE 1 (residues 1 to 435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 435) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09988. Method: conceptual translation. FEATURES Location/Qualifiers source 1..435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..435 /product="Npl6p" /calculated_mol_wt="49520" Region 121..253 /region_name="CRC_subunit" /note="Chromatin remodelling complex Rsc7/Swp82 subunit; pfam08624" /db_xref="CDD:430112" CDS 1..435 /gene="NPL6" /locus_tag="YMR091C" /gene_synonym="RSC7" /coded_by="NM_001182591.1:1..1308" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019|PMID:12183366|PMID:14729968]" /note="Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions" /db_xref="GeneID:855116" /db_xref="SGD:S000004697" ORIGIN 1 msdsegglas evehekrsrs tsnrpnyaid tedldidend enedddyree eanegvneee 61 isdeeeqink sgrnkrrhvd eeedlsedkg vtrsrnrskf kkpvfpgidd aeenlnplkv 121 vneeyvlpdd pegetkitad gdllggrefl vrtftltekg nrkfmlatep arivgfrdsy 181 lffqthpnly kfilnqtqkn dlidrgvlpy syrnrqialv targvfkefg akiirggkhi 241 tddyyaselr tkgnviegkl agdpidksar aletmmypas enginpaknq veffehrphg 301 hmsnsniias gsklsstnwl yqhsaacsrf nsdlfydrvk vllvdqqglr daytnilhip 361 estqsttvlg wrrskndsps dtsivyetvi hdndlnkpkt glseipkeiy edvvdedvlr 421 aiteqqnfek cneyi // LOCUS NP_013810 615 aa linear PLN 30-JUN-2025 DEFINITION Aip1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013810 VERSION NP_013810.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182592.1 REFERENCE 1 (residues 1 to 615) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 615) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 615) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 615) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 615) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09989. Method: conceptual translation. FEATURES Location/Qualifiers source 1..615 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..615 /product="Aip1p" /calculated_mol_wt="67195" Region 58..363 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(62,83,87,93,98,114..115,133,137,146,158..159,176,182, 188..189,202,223,228,234..235,247..248,269,273,279..280, 294..295,318,324..325,337..338,352,356,362..363) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 67..114 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 120..158 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 163..199 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 200..612 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 210..246 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 256..291 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 387..442 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 449..482 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 490..531 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 534..568 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 587..612 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..615 /gene="AIP1" /locus_tag="YMR092C" /coded_by="NM_001182592.1:1..1848" /experiment="EXISTENCE:direct assay:GO:0003779 actin binding [PMID:10366597]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005884 actin filament [PMID:23333351]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10366597]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0030042 actin filament depolymerization [PMID:10366597]" /experiment="EXISTENCE:genetic interaction:GO:0032466 negative regulation of cytokinesis [PMID:25371407]" /experiment="EXISTENCE:mutant phenotype:GO:0051016 barbed-end actin filament capping [PMID:23333351]" /experiment="EXISTENCE:physical interaction:GO:0030042 actin filament depolymerization [PMID:10366597]" /note="Actin cortical patch component; interacts with the actin depolymerizing factor cofilin; inhibits elongation of aged ADP-actin filaments decorated with cofilin to maintain a high level of assembly-competent actin species; required to restrict cofilin localization to cortical patches; putative regulator of cytokinesis; contains WD repeats; mutations in human homolog WDR1 are associated with cardiac hypertrophy" /db_xref="GeneID:855117" /db_xref="SGD:S000004698" ORIGIN 1 mssislkeii ppqpstqrnf tthlsydptt naiaypcgks afvrclddgd skvppvvqft 61 ghgssvvttv kfspikgsqy lcsgdesgkv ivwgwtfdke snsvevnvks efqvlagpis 121 diswdfegrr lcvvgegrdn fgvfiswdsg nslgevsghs qrinachlkq srpmrsmtvg 181 ddgsvvfyqg ppfkfsasdr thhkqgsfvr dvefspdsge fvitvgsdrk iscfdgksge 241 flkyieddqe pvqggifals wldsqkfatv gadatirvwd vttskcvqkw tldkqqlgnq 301 qvgvvatgng riislsldgt lnfyelghde vlktisghnk gitaltvnpl isgsydgrim 361 ewssssmhqd hsnlivsldn skaqeyssis wddtlkvngi tkhefgsqpk vasanndgft 421 avltndddll ilqsftgdii ksvrlnspgs avslsqnyva vgleegntiq vfklsdlevs 481 fdlktplrak psyisispse tyiaagdvmg killydlqsr evktsrwafh tskinaiswk 541 paekganeee ieedlvatgs ldtnifiysv krpmkiikal nahkdgvnnl lwetpstlvs 601 sgadacikrw nvvle // LOCUS NP_013811 513 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-binding rRNA-processing protein UTP15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013811 VERSION NP_013811.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182593.1 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09990. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..513 /product="snoRNA-binding rRNA-processing protein UTP15" /calculated_mol_wt="57555" Region <33..321 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 43..79 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 84..122 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 128..166 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 171..208 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 216..248 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 255..294 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 365..511 /region_name="UTP15_C" /note="UTP15 C terminal; pfam09384" /db_xref="CDD:462782" CDS 1..513 /gene="UTP15" /locus_tag="YMR093W" /coded_by="NM_001182593.1:1..1542" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:15489292]" /experiment="EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]" /note="Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA" /db_xref="GeneID:855118" /db_xref="SGD:S000004699" ORIGIN 1 mstarpriit skapllpqqt tpeqrywrqy tsaqlvkehn svthisfnpq hphdfavtss 61 trvqifssrt rqviktfsrf kdvvysasfr sdgkllcagd atglvsvyds ynprtillsi 121 nasthpthvt kfhtqdnkil atasddrvtr lwdisnayep qleltgatdy vrtlsfipaa 181 phlvatgsyd glirlydtrs sgstpiysln hdqpvenvia vsptqivscg gnnfkvwdlt 241 snkklyergn fnkavtcldy venfdspmqs aliassldgh vkvfdpldnf qvkfgwkfsg 301 pvlscavsps taqgnrhlva glssgllair tkkkekrssd kenapasfnk naksnnfqrm 361 mrgseyqgdq ehiihndkvr sqrrmrafer ninqfkwsea ldnafvpgma keltltvlqe 421 lrkrgkvrva lygrdestle pllnwclkgi edvrsasiva dwvavvlely gntlesspvl 481 qelmidlktk vrheihkske aqriegmlql lts // LOCUS NP_013812 478 aa linear PLN 30-JUN-2025 DEFINITION Ctf13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013812 VERSION NP_013812.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182594.1 REFERENCE 1 (residues 1 to 478) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 478) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 478) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09991. Method: conceptual translation. FEATURES Location/Qualifiers source 1..478 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..478 /product="Ctf13p" /calculated_mol_wt="56205" Region 163..477 /region_name="Ctf13_LRR_LRR-insertion" /note="leucine-rich-repeat (LRR) domain and LRR insertion domain of centromere DNA-binding protein complex CBF3 subunit C (Ctf13); cd19611" /db_xref="CDD:381623" Region 164..191 /region_name="LRR1" /note="LRR1 [structural motif]" /db_xref="CDD:381623" Region 195..271 /region_name="LRR2" /note="LRR2 [structural motif]" /db_xref="CDD:381623" Site order(271,274,303,307..308,330,333,354..355) /site_type="other" /note="CDEIII binding site [nucleotide binding]" /db_xref="CDD:381623" Region 273..296 /region_name="LRR3" /note="LRR3 [structural motif]" /db_xref="CDD:381623" Region 309..333 /region_name="LRR4" /note="LRR4 [structural motif]" /db_xref="CDD:381623" Region 334..354 /region_name="LRR5" /note="LRR5 [structural motif]" /db_xref="CDD:381623" Region 356..376 /region_name="LRR6" /note="LRR6 [structural motif]" /db_xref="CDD:381623" Site order(362,404,406,443,467..468) /site_type="other" /note="Skp1 interface [polypeptide binding]" /db_xref="CDD:381623" Site order(398..399,402,421,424..425,428..429,431,435,438, 457..458,460..461,463) /site_type="other" /note="Cep3 interface [polypeptide binding]" /db_xref="CDD:381623" Region 437..457 /region_name="LRR7" /note="LRR7 [structural motif]" /db_xref="CDD:381623" Region 464..477 /region_name="LRR8" /note="LRR8 [structural motif]" /db_xref="CDD:381623" CDS 1..478 /gene="CTF13" /locus_tag="YMR094W" /coded_by="NM_001182594.1:1..1437" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:10097110]" /experiment="EXISTENCE:direct assay:GO:0031518 CBF3 complex [PMID:8706132|PMID:1997204|PMID:8670864]" /experiment="EXISTENCE:direct assay:GO:0051382 kinetochore assembly [PMID:12084919]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:16330709]" /note="Subunit of the CBF3 complex; F-box protein of the leucine-rich-repeat family; required for assembly of the complex; CBF3 binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis" /db_xref="GeneID:855119" /db_xref="SGD:S000004700" ORIGIN 1 mpsfnpvrfl elpidirkev yfhldgnfcg ahpypidily ksndvelpgk psykrskrsk 61 kllrymypvf atylnifeys pqliekwley afwlrydclv ldcfkvnhly dgtlidalew 121 tyldnelrla yfnkasmlev wytfkeykkw vidsvafdel dllnvsniqf nidnltpqlv 181 dkclsileqk dlfatigevq fgqdeevgee kdvdvsgans densspssti knkkrsaskr 241 shsdngnvga thnqltsisv irtirsmesm kslrkitvrg eklyellinf hgfrdnpgkt 301 isyivkrrin eirlsrmnqi srtgladftr wdnlqklvls rvayidlnsi vfpknfkslt 361 mkrvskikww nieenilkel kvdkrtfksl yikeddskft kffnlrhtri keldkseinq 421 itylrcqaiv wlsfrtlnhi klqnvsevfn niivpralfd skrveiyrce kisqvlvi // LOCUS NP_013813 224 aa linear PLN 30-JUN-2025 DEFINITION putative pyridoxal 5'-phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013813 VERSION NP_013813.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182595.1 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09992. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..224 /product="putative pyridoxal 5'-phosphate synthase" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /calculated_mol_wt="24776" Region 18..223 /region_name="SNO" /note="SNO glutamine amidotransferase family; pfam01174" /db_xref="CDD:334414" Site order(66..68,100,129,160..161,203,205) /site_type="active" /note="predicted active site [active]" /db_xref="CDD:153220" Site order(100,203,205) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:153220" CDS 1..224 /gene="SNO1" /locus_tag="YMR095C" /coded_by="NM_001182595.1:1..675" /experiment="EXISTENCE:direct assay:GO:0004359 glutaminase activity [PMID:14764090]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0008615 pyridoxine biosynthetic process [PMID:14764090]" /experiment="EXISTENCE:mutant phenotype:GO:0036001 'de novo' pyridoxal 5'-phosphate biosynthetic process [PMID:30498136]" /experiment="EXISTENCE:mutant phenotype:GO:0042819 vitamin B6 biosynthetic process [PMID:12271461]" /experiment="EXISTENCE:mutant phenotype:GO:0043066 negative regulation of apoptotic process [PMID:18355271]" /experiment="EXISTENCE:physical interaction:GO:1903600 glutaminase complex [PMID:14764090]" /note="Protein of unconfirmed function; involved in pyridoxine metabolism; expression is induced during stationary phase; forms putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase; sno1-delta affects abundance of mRNA from downstream gene CTF13" /db_xref="GeneID:855120" /db_xref="SGD:S000004701" ORIGIN 1 mhkthstmsg ksmkvigvla lqgaflehtn hlkrclaend ygikieiktv ktpedlaqcd 61 aliipggest smsliaqrtg lypclyefvh npekvvwgtc agliflsaql enesalvktl 121 gvlkvdvrrn afgrqaqsft qkcdfsnfip gcdnfpatfi rapvierild piavkslyel 181 pvngkdvvva atqnhnilvt sfhpeladsd trfhdwfirq fvsn // LOCUS NP_013814 297 aa linear PLN 30-JUN-2025 DEFINITION pyridoxine biosynthesis protein SNZ1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013814 VERSION NP_013814.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182596.1 REFERENCE 1 (residues 1 to 297) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 297) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 297) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 297) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09993. Method: conceptual translation. FEATURES Location/Qualifiers source 1..297 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..297 /product="pyridoxine biosynthesis protein SNZ1" /EC_number="4.3.3.6" /calculated_mol_wt="31686" Region 8..297 /region_name="TIGR00343" /note="pyridoxal 5'-phosphate synthase, synthase subunit Pdx1" /db_xref="CDD:129443" Site order(23,42,80,152..154,214,233) /site_type="active" /db_xref="CDD:240078" Site order(57,59,67,82,85..87,90,107..111,153..155,157,160..161, 164,216,219..220,261) /site_type="other" /note="multimer interface [polypeptide binding]" /db_xref="CDD:240078" CDS 1..297 /gene="SNZ1" /locus_tag="YMR096W" /coded_by="NM_001182596.1:1..894" /experiment="EXISTENCE:direct assay:GO:0036381 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity [PMID:19523954]" /experiment="EXISTENCE:genetic interaction:GO:0008615 pyridoxine biosynthetic process [PMID:14764090|PMID:30498136]" /experiment="EXISTENCE:mutant phenotype:GO:0008615 pyridoxine biosynthetic process [PMID:30498136]" /experiment="EXISTENCE:mutant phenotype:GO:0042819 vitamin B6 biosynthetic process [PMID:12271461]" /experiment="EXISTENCE:physical interaction:GO:1903600 glutaminase complex [PMID:14764090]" /note="Subunit of a two-component pyridoxal-5'-phosphate synthase; involved in pyridoxine (vitamin B6) biosynthesis from glyceraldehyde-3-phosphate, ribose-5-phosphate and ammonia liberated from glutamine by glutaminase; forms a complex with Sno1p that functions as an active glutaminase; member of a stationary phase-induced gene family where transcriptional induction occurs during the postdiauxic phase; co-regulated with SNO1; paralog of SNZ2 and SNZ3" /db_xref="GeneID:855121" /db_xref="SGD:S000004702" ORIGIN 1 mtgedfkiks glaqmlkggv imdvvtpeqa kiaeksgaca vmalesipad mrksgkvcrm 61 sdpkmikdim nsvsipvmak vrighfveaq iiealevdyi desevltpad wthhiekdkf 121 kvpfvcgakd lgealrrine gaamirtkge agtgdvseav khirriteei kacqqlksed 181 diakvaeemr vpvsllkdvl ekgklpvvnf aaggvatpad aallmqlgcd gvfvgsgifk 241 ssnpvrlata vveatthfdn pskllevssd lgelmggvsi esishasngv rlseigw // LOCUS NP_013815 367 aa linear PLN 30-JUN-2025 DEFINITION putative GTPase MTG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013815 VERSION NP_013815.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182597.1 REFERENCE 1 (residues 1 to 367) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 367) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 367) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 367) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09994. Method: conceptual translation. FEATURES Location/Qualifiers source 1..367 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..367 /product="putative GTPase MTG1" /calculated_mol_wt="42013" Region 34..225 /region_name="YlqF" /note="Circularly permuted YlqF GTPase; cd01856" /db_xref="CDD:206749" Site order(89..90,92..93,119..121,159..165,224) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206749" Site 89..92 /site_type="other" /note="G4 box" /db_xref="CDD:206749" Site 119..121 /site_type="other" /note="G5 box" /db_xref="CDD:206749" Region 155..321 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site 157..164 /site_type="other" /note="G1 box" /db_xref="CDD:206749" Site 157..164 /site_type="other" /note="G1 box" /db_xref="CDD:206648" Site order(194..199,201..202) /site_type="other" /note="Switch I region" /db_xref="CDD:206749" Site 197 /site_type="other" /note="G2 box" /db_xref="CDD:206749" Site 197 /site_type="other" /note="G2 box" /db_xref="CDD:206648" Site 200..202 /site_type="other" /note="Switch I region" /db_xref="CDD:206648" Site 221..224 /site_type="other" /note="G3 box" /db_xref="CDD:206749" Site 221..224 /site_type="other" /note="G3 box" /db_xref="CDD:206648" Site order(223..224,258..259) /site_type="other" /note="Switch II region" /db_xref="CDD:206648" Site 223..225 /site_type="other" /note="Switch II region" /db_xref="CDD:206749" Site 298..301 /site_type="other" /note="G4 box" /db_xref="CDD:206648" CDS 1..367 /gene="MTG1" /locus_tag="YMR097C" /coded_by="NM_001182597.1:1..1104" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:12808030]" /experiment="EXISTENCE:genetic interaction:GO:1902775 mitochondrial large ribosomal subunit assembly [PMID:12808030]" /experiment="EXISTENCE:mutant phenotype:GO:1902775 mitochondrial large ribosomal subunit assembly [PMID:12808030]" /note="Putative GTPase peripheral to the mitochondrial inner membrane; essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals" /db_xref="GeneID:855122" /db_xref="SGD:S000004703" ORIGIN 1 mhinvrgtrk iisnvssftp ryefpkysmp ltdfkghqvk alktfekllp qmnmiielrd 61 iraplstrnv vfdriarkeh dvmklvvytr kdlmpgnkpy igklknwhee lgekfilldc 121 rnktdvrnll kilewqnyel etnggylpmg yralitgmpn vgkstlinsl rtifhnqvnm 181 grkfkkvakt gaeagvtrat sevirvtsrn tesrneiyli dtpgigvpgr vsdhnrmlgl 241 alcgsvknnl vdpifqadyl lylmnlqnln dgrtelypgs tnsptndiyd vlrrlqvnks 301 qnekstaiew tnkwrlhgkg iifdpevlln ndefsyknyv ndqleklgdl syeglsnklk 361 gnpnqvf // LOCUS NP_013816 612 aa linear PLN 30-JUN-2025 DEFINITION Atp25p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013816 VERSION NP_013816.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182598.1 REFERENCE 1 (residues 1 to 612) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 612) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 612) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 612) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09995. Method: conceptual translation. FEATURES Location/Qualifiers source 1..612 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..612 /product="Atp25p" /calculated_mol_wt="70283" Region 105..246 /region_name="RsfS" /note="Ribosomal silencing factor during starvation; pfam02410" /db_xref="CDD:460550" Region 306..594 /region_name="mRNA_stabil" /note="mRNA stabilization; pfam13929" /db_xref="CDD:433586" CDS 1..612 /gene="ATP25" /locus_tag="YMR098C" /coded_by="NM_001182598.1:1..1839" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:18216280]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:18216280]" /experiment="EXISTENCE:mutant phenotype:GO:0048255 mRNA stabilization [PMID:18216280]" /note="Protein that associates with mitochondrial ribosome; required for the stability of Oli1p (Atp9p) mRNA; also required for the Oli1p ring formation; YMR098C is not an essential gene" /db_xref="GeneID:855123" /db_xref="SGD:S000004704" ORIGIN 1 mnkfcllpfh gkrigvanip ftilfkkgpy flhshitavy ystkgkndsh eqsrvskkst 61 ftpletpwyl rivdnekelm egkknnhhtm nkeleipkts pnslrkiadl ltgklglddf 121 lvfdlrkksp nsvsavnklg dfmvictars tkhchksfle lnkflkhefc ssayvegnfn 181 erqesrrkrr larksnlskl lgrssecsak dlnseawymi dcrvdgifvn iltqrrrnel 241 nleelyapen ekskfqnids gnvptisgvn eissnnnill glrrlaqqrr rystinpngl 301 snlryflqke dfkgankiiq sssgtethni rtlehvkntl kdlvgqerkv dvvqwkslfd 361 ehstfltinq saaywplrle yaillnkadp qfysdrvflk dylllkkslg qeliredlia 421 llemvlktqh sshsyfnlvk qnrviiraln lfkglqtedd gsvvydevvi slllnsmvad 481 ervklrslye tidhifqtfg dkltsgmivs ilqnlakikd wnkllqvwea itptegegqd 541 krpwnefinv inqsgdshvi skivnnghll wirrlnvnvt pelcnsikal lktagmenst 601 leeflvrgtn nq // LOCUS NP_013817 297 aa linear PLN 30-JUN-2025 DEFINITION glucose-6-phosphate 1-epimerase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013817 VERSION NP_013817.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182599.1 REFERENCE 1 (residues 1 to 297) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 297) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 297) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 297) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09996. Method: conceptual translation. FEATURES Location/Qualifiers source 1..297 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..297 /product="glucose-6-phosphate 1-epimerase" /EC_number="5.1.3.15" /calculated_mol_wt="33825" Region 10..286 /region_name="D-hex-6-P-epi_like" /note="D-hexose-6-phosphate epimerase-like; cd09020" /db_xref="CDD:185697" Site order(57,82,86,159,161,203,238,264) /site_type="active" /db_xref="CDD:185697" Site order(57,86) /site_type="other" /note="phosphate binding residues" /db_xref="CDD:185697" Site order(159,264) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:185697" CDS 1..297 /locus_tag="YMR099C" /coded_by="NM_001182599.1:1..894" /experiment="EXISTENCE:curator inference:GO:0005975 carbohydrate metabolic process [PMID:16857670]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0047938 glucose-6-phosphate 1-epimerase activity [PMID:16857670]" /note="Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase); likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:855125" /db_xref="SGD:S000004705" ORIGIN 1 mpiketdkev vlthpadett svhilkygat vyswklksee qlwlstaakl dgskpvrggi 61 plvfpvfgkn stdehlsklp qhglarnstw eflgqtkenp ptvqfglkpe ianpeltklw 121 pmdylliltv elgsdylkta ieventsssk elkfnwlfht yfriediegt mvsnlagmkl 181 ydqllkesyv dkhpvvtfnq etdviyqnvs aeraiqivdk gvqihtlkry nlpdtvvwnp 241 wieksqgmad fepktgyqqm iciepghvhd fislapgkkw nayqllckee lkyqaiq // LOCUS NP_013818 620 aa linear PLN 30-JUN-2025 DEFINITION MYND-type zinc finger protein MUB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013818 VERSION NP_013818.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182600.1 REFERENCE 1 (residues 1 to 620) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 620) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 620) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 620) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09997. Method: conceptual translation. FEATURES Location/Qualifiers source 1..620 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..620 /product="MYND-type zinc finger protein MUB1" /calculated_mol_wt="72120" Region 512..555 /region_name="zf-MYND" /note="MYND finger; pfam01753" /db_xref="CDD:460312" CDS 1..620 /gene="MUB1" /locus_tag="YMR100W" /coded_by="NM_001182600.1:1..1863" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:18070918]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:18070918]" /experiment="EXISTENCE:physical interaction:GO:1990304 MUB1-RAD6-UBR2 ubiquitin ligase complex [PMID:18070918]" /note="MYND domain-containing protein; component of the Mub1p-Ubr2p-Rad6p ubiquitin ligase complex, required for ubiquitination and degradation of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; proposed to function as both a partner and substrate of the Ubr2p/Rad6p ubiquitin ligase; similar to the A. nidulans samB gene" /db_xref="GeneID:855126" /db_xref="SGD:S000004706" ORIGIN 1 mrdsnhrslt snkpivtits tvydrraldi nssiplinsl nyltyltsns skvretvand 61 galerlvsil rschlslfel ldldlenfne henikdlwke krlalcawkw tltfqclvlt 121 gtrgteqirk kvvmsgvlsv lvtvldnyll yhknydfikd qtmtfdfkgi ttetmykfmr 181 kdenetyqqy iefitgqdkl klstdknfln erlvapsmti ptdfsdiwgr fadlasnfep 241 dqerhdddid idsevesenf dahknffsqp dinrptistp refflgrivp kqddviwslq 301 llafvskyty mkstlqnvel veslsfrsma ykikqrisee ndleeqerdv tvklsslypy 361 lsknpennsk vkaldtskmd pffkeleels nrcqqeeqne icnnhcpvln lferyrvpkp 421 sddnaygkdk erinlrkkis dnferrwsyd kmkkeltniv yknkvltnvv nifplvekyt 481 vsaenthdvi ywssvimrns crkneilgvr qcanfscgkw edfprqfakc rrckrtkycs 541 rkcqlkawgy hrywchevgs shmrstnttt gvntpnepss lnatattaad vsnststftp 601 nisttvpdei snrdensipe // LOCUS NP_013819 343 aa linear PLN 30-JUN-2025 DEFINITION ditrans,polycis-polyprenyl diphosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013819 VERSION NP_013819.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182601.1 REFERENCE 1 (residues 1 to 343) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 343) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 343) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 343) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09998. Method: conceptual translation. FEATURES Location/Qualifiers source 1..343 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..343 /product="ditrans,polycis-polyprenyl diphosphate synthase" /EC_number="2.5.1.87" /calculated_mol_wt="40069" Region 68..292 /region_name="uppS" /note="undecaprenyl diphosphate synthase; TIGR00055" /db_xref="CDD:129165" Site order(74..79,88,92,96,99,118,126,130,137..138,141,195,247, 253,255) /site_type="active" /db_xref="CDD:259850" Site order(202..203,205..206,209..210,224..226,229,241,252..256, 259..261,263..264,266..268,270) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:259850" CDS 1..343 /gene="SRT1" /locus_tag="YMR101C" /coded_by="NM_001182601.1:1..1032" /experiment="EXISTENCE:direct assay:GO:0004659 prenyltransferase activity [PMID:17345630]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24390141|PMID:11442630]" /experiment="EXISTENCE:direct assay:GO:0006486 protein glycosylation [PMID:11442630]" /experiment="EXISTENCE:direct assay:GO:0043048 dolichyl monophosphate biosynthetic process [PMID:25066056]" /experiment="EXISTENCE:direct assay:GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity [PMID:11442630|PMID:25066056]" /experiment="EXISTENCE:direct assay:GO:1904423 dehydrodolichyl diphosphate synthase complex [PMID:25066056]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:11442630]" /note="Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1; involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase" /db_xref="GeneID:855127" /db_xref="SGD:S000004707" ORIGIN 1 mkmpsiiqiq fvalkrllve tkeqmcfavk sifqrvfawv mslslfswfy vnlqnilika 61 lrvgpvpehv sfimdgnrry aksrrlpvkk gheaggltll tllyickrlg vkcvsayafs 121 ienfnrpkee vdtlmnlftv kldefakrak dykdplygsk irivgdqsll spemrkkikk 181 veeitqdgdd ftlficfpyt srndmlhtir dsvedhlenk sprinirkft nkmymgfhsn 241 kcellirtsg hrrlsdymlw qvhenatief sdtlwpnfsf famylmilkw sffstiqkyn 301 eknhslfeki hesvpsifkk kktamslynf pnppisvsvt gde // LOCUS NP_013820 834 aa linear PLN 30-JUN-2025 DEFINITION Laf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013820 VERSION NP_013820.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182602.1 REFERENCE 1 (residues 1 to 834) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 834) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 834) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 834) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 834) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 834) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 834) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA09999. Method: conceptual translation. FEATURES Location/Qualifiers source 1..834 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..834 /product="Laf1p" /calculated_mol_wt="94124" Region <170..506 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 176..221 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 234..276 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 281..315 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 322..358 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 363..400 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 430..472 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 480..502 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..834 /gene="LAF1" /locus_tag="YMR102C" /coded_by="NM_001182602.1:1..2505" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:33255682]" /note="Sterol-binding beta-propeller protein; physically associates with sterol-binding StARkin domain-containing proteins Ysp2/Lam2/Ltc4 and Lam4/Ltc3; essential for retrograde transport of ergosterol from the plasma membrane to the endoplasmic reticulum at ER-PM contact sites; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; non-essential gene; has a paralog, DGR2, that arose from the whole genome duplication" /db_xref="GeneID:855128" /db_xref="SGD:S000004708" ORIGIN 1 mtnmaedkts iskvhsefsn ssnttgseee srshqesfdg esssgesksk sklnleysad 61 ieplkfrmtk tnntndklky snngnatdsf mrlkehlqrg ntlnsnlrvn efypfnsidt 121 eqfenylrep kyikmlkrrk nlkqfrrlfl aqelmayege tvtstsksse ptskaiwstk 181 fsrdgkfmat gskdgkiriw kvigspvera eldssaesnk earaksmrik qqvsslnnpk 241 ekqfldsate kyeekeklln lyapvfhptp lrlykehvqd vldinwsknn filsasmdkt 301 vklwhpdrkn slktfihpdf vtcvefhptd drffisgcld hkcrlwsild devsfeydcq 361 dlitsvtlsp eegkytiigt fngyvhilmt rgltpvssfh vadrqtqeqn ahvmvtetds 421 kirhgprvtg lqafrsqldn sfrlvvtsnd sririfdleq rkllevlkgf hsgssqhkaq 481 lsiwhgqpiv vnssddhwvy gwrlkssdre ndqdepkrkp kglarsgslr sifsksmsrs 541 ssqnneekph hhlkltnllp lphhsndhyi kntdyisfha hnapvtcvsi appetsktls 601 lsndvicels leffqtsdsf dvlsrsnddg imsdvesslg ynskpgsisn asatsaipdv 661 vdaigtilis tdnvgtirvf radmpsvirk rvllkleeyn revrrrfnss dslhslsrsf 721 nsraksnlag qpaaaytntg kgyatgrgys nicpksstsl ktlgsnaqpr tpresmssif 781 snahgpttpt samnlpircn vcngsrfeaf sgandqqdrn yycvdcgtvv nnfr // LOCUS NP_001335806 120 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR103C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335806 VERSION NP_001335806.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348866.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80326. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..120 /product="uncharacterized protein" /calculated_mol_wt="13135" CDS 1..120 /locus_tag="YMR103C" /coded_by="NM_001348866.1:1..363" /note="hypothetical protein; conserved among S. cerevisiae strains; YMR103C is not an essential gene" /db_xref="GeneID:855129" /db_xref="SGD:S000004709" ORIGIN 1 mvrrgcalll atltrlmlli hffysiiril pstelrsktd llsaegrtli padvkakpag 61 rksrlpefak rqrtlalper kdslfcllpl flhslgreql issaddpgfp cagsamgslt // LOCUS NP_013822 677 aa linear PLN 30-JUN-2025 DEFINITION putative protein kinase YPK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013822 VERSION NP_013822.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182604.1 REFERENCE 1 (residues 1 to 677) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 677) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 677) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 677) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 677) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 677) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 677) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10000. Method: conceptual translation. FEATURES Location/Qualifiers source 1..677 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..677 /product="putative protein kinase YPK2" /EC_number="2.7.11.1" /calculated_mol_wt="76534" Region 114..339 /region_name="YPK1_N_like" /note="Fungal protein kinase domain similar to the N-terminus of YPK1; cd11651" /db_xref="CDD:212165" Region 349..660 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(350..353,356,358,371,373,405,421..424,467,471..472, 474,484..485) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270737" CDS 1..677 /gene="YPK2" /locus_tag="YMR104C" /gene_synonym="YKR2" /coded_by="NM_001182604.1:1..2034" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:16478726]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12221112]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:12221112]" /experiment="EXISTENCE:genetic interaction:GO:0070941 eisosome assembly [PMID:18296441]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:16478726]" /note="AGC-type S/T protein kinase; participates in the cell wall integrity signaling pathway; involved with Ypk1p in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6), and in the direct phosphorylation of the Myo5p motor domain TEDS site; phosphorylated and activated by Pkh1/2p in the presence of phytosphingosine; direct phosphorylation by Tor2p regulates actin polarization; genetically redundant with YPK1; human homolog SGK2 can complement the inviability of a ypk1 ypk2 mutant" /db_xref="GeneID:855130" /db_xref="SGD:S000004710" ORIGIN 1 mhswriskfk lgrskeddgs sedenekswg nglfhfhhge khhdgspknh nhehehhirk 61 intnetlpss lsspklrnda sfknpsgign dnskaserka sqsstetqgp ssesglmtvk 121 vysgkdftlp fpitsnstil qkllssgilt sssndaseva aimrqlpryk rvdqdsageg 181 lidrafatkf ipssillpgs tnsspllyft iefdnsitti spdmgtmeqp vfnkistfdv 241 trklrflkid vfaripslll psknwqqeig eqdevlkeil kkintnqdih ldsfhlplnl 301 kidsaaqirl ynhhwisler gygklnitvd ykpsknkpls iddfdllkvi gkgsfgkvmq 361 vrkkdtqkiy alkalrkayi vskcevthtl aertvlarvd cpfivplkfs fqspeklylv 421 lafinggelf yhlqhegrfs larsrfyiae llcaldslhk ldviyrdlkp enilldyqgh 481 ialcdfglck lnmkdndktd tfcgtpeyla peillgqgyt ktvdwwtlgi llyemmtglp 541 pyydenvpvm ykkilqqpll fpdgfdpaak dlligllsrd psrrlgvngt deirnhpffk 601 diswkklllk gyippykpiv kseidtanfd qeftkekpid svvdeylsas iqkqfggwty 661 igdeqlgdsp sqgrsis // LOCUS NP_013823 569 aa linear PLN 30-JUN-2025 DEFINITION phosphoglucomutase PGM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013823 VERSION NP_013823.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182605.1 REFERENCE 1 (residues 1 to 569) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 569) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 569) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 569) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 569) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10001. Method: conceptual translation. FEATURES Location/Qualifiers source 1..569 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..569 /product="phosphoglucomutase PGM2" /EC_number="5.4.2.2" /calculated_mol_wt="62958" Region 6..569 /region_name="PGM1" /note="Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; cd03085" /db_xref="CDD:100087" Site order(21,119,295,338,359,361,378,380,382,510,512..514,522) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:100087" Site order(48..49,53..54,107,135..137,369) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:100087" Site order(119..121,290,292,294..295,361,391,510,512..514,522) /site_type="active" /db_xref="CDD:100087" Site order(119,290,292,294) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:100087" CDS 1..569 /gene="PGM2" /locus_tag="YMR105C" /gene_synonym="GAL5" /coded_by="NM_001182605.1:1..1710" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8385141]" /experiment="EXISTENCE:genetic interaction:GO:0004614 phosphoglucomutase activity [PMID:8119301]" /experiment="EXISTENCE:genetic interaction:GO:0005978 glycogen biosynthetic process [PMID:9252577]" /experiment="EXISTENCE:genetic interaction:GO:0005992 trehalose biosynthetic process [PMID:9252577]" /experiment="EXISTENCE:genetic interaction:GO:0006011 UDP-alpha-D-glucose metabolic process [PMID:9252577]" /experiment="EXISTENCE:genetic interaction:GO:0006874 intracellular calcium ion homeostasis [PMID:15252028]" /experiment="EXISTENCE:genetic interaction:GO:0019255 glucose 1-phosphate metabolic process [PMID:8119301]" /experiment="EXISTENCE:genetic interaction:GO:0019388 galactose catabolic process [PMID:8119301]" /experiment="EXISTENCE:genetic interaction:GO:0051156 glucose 6-phosphate metabolic process [PMID:8119301]" /experiment="EXISTENCE:mutant phenotype:GO:0004614 phosphoglucomutase activity [PMID:13887540|PMID:8119301|PMID:2138705]" /experiment="EXISTENCE:mutant phenotype:GO:0006874 intracellular calcium ion homeostasis [PMID:15252028|PMID:10681519]" /experiment="EXISTENCE:mutant phenotype:GO:0019255 glucose 1-phosphate metabolic process [PMID:10681519|PMID:8119301]" /experiment="EXISTENCE:mutant phenotype:GO:0019388 galactose catabolic process [PMID:14264884|PMID:8119301|PMID:13887540]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:15164360]" /note="Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress; PGM2 has a paralog, PGM1, that arose from the whole genome duplication" /db_xref="GeneID:855131" /db_xref="SGD:S000004711" ORIGIN 1 msfqietvpt kpyedqkpgt sglrkktkvf kdepnytenf iqsimeaipe gskgatlvvg 61 gdgryyndvi lhkiaaigaa ngikklvigq hgllstpaas himrtyeekc tggiiltash 121 npggpendmg ikynlsnggp apesvtnaiw eiskkltsyk iikdfpeldl gtigknkkyg 181 pllvdiidit kdyvnflkei fdfdlikkfi dnqrstknwk llfdsmngvt gpygkaifvd 241 efglpadevl qnwhpspdfg gmhpdpnlty asslvkrvdr ekiefgaasd gdgdrnmiyg 301 ygpsfvspgd svaiiaeyaa eipyfakqgi yglarsfpts gaidrvakah glncyevptg 361 wkffcalfda kklsicgees fgtgsnhvre kdgvwaimaw lnilaiynkh hpeneasikt 421 iqnefwakyg rtfftrydfe kvetekanki vdqlrayvtk sgvvnsafpa deslkvtdcg 481 dfsytdldgs vsdhqglyvk lsngarfvlr lsgtgssgat irlyiekycd dksqyqktae 541 eylkpiinsv ikflnfkqvl gteeptvrt // LOCUS NP_878142 64 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR105W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878142 VERSION NP_878142.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184614.1 REFERENCE 1 (residues 1 to 64) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 64) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 64) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 64) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10002. Method: conceptual translation. FEATURES Location/Qualifiers source 1..64 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..64 /product="uncharacterized protein" /calculated_mol_wt="7097" CDS 1..64 /locus_tag="YMR105W-A" /coded_by="NM_001184614.1:1..195" /note="hypothetical protein" /db_xref="GeneID:1466500" /db_xref="SGD:S000028692" ORIGIN 1 milvhtgnvl yprfivvaft feqrqggrck ggkatcmasv qsykvtmqis smtiiyplfi 61 ffsl // LOCUS NP_013824 629 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent DNA helicase YKU80 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013824 VERSION NP_013824.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182606.1 REFERENCE 1 (residues 1 to 629) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 629) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 629) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 629) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10003. Method: conceptual translation. FEATURES Location/Qualifiers source 1..629 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..629 /product="ATP-dependent DNA helicase YKU80" /EC_number="3.6.4.12" /calculated_mol_wt="71110" Region 5..232 /region_name="Ku_N" /note="Ku70/Ku80 N-terminal alpha/beta domain; pfam03731" /db_xref="CDD:427470" Site order(44,47,49,77,79,207..208,210..212) /site_type="active" /note="interface residues [active]" /db_xref="CDD:238735" Region 244..583 /region_name="KU80" /note="Ku-core domain, Ku80 subfamily; Ku80 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the...; cd00873" /db_xref="CDD:238445" Site order(256,259,266,268..271,275,277..278,280,286,296..303, 308,312,314..316,318..322,333,335,345..348,352,355..356, 358..359,362,373,375,378,381,383,392,397,405,416,429,436, 439..441,443,446..449,475,479,481,483,502,505,507..509,519, 524,527..528,556,559..561,570,579..582) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:238445" Site order(266,276..277,299,328,340,361,400..405,443) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238445" CDS 1..629 /gene="YKU80" /locus_tag="YMR106C" /gene_synonym="HDF2" /coded_by="NM_001182606.1:1..1890" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16166630]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:11553718]" /experiment="EXISTENCE:direct assay:GO:0007535 donor selection [PMID:16166630]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:17656141]" /experiment="EXISTENCE:direct assay:GO:0043564 Ku70:Ku80 complex [PMID:8754818]" /experiment="EXISTENCE:direct assay:GO:0070034 telomerase RNA binding [PMID:12975323]" /experiment="EXISTENCE:genetic interaction:GO:0007535 donor selection [PMID:16809780]" /experiment="EXISTENCE:genetic interaction:GO:0034502 protein localization to chromosome [PMID:18716325]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:11016833]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:27122604]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0007535 donor selection [PMID:16809780|PMID:16166630]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0097695 establishment of protein-containing complex localization to telomere [PMID:15531893]" /note="Subunit of telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein via interaction with TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; colocalizes with quiescent cell telomere hyperclusters" /db_xref="GeneID:855132" /db_xref="SGD:S000004712" ORIGIN 1 mssesttfiv dvspsmmknn nvsksmayle ytllnkskks rktdwiscyl ancpvsensq 61 eipnvfqiqs flapvtttat igfikrlkqy cdqhshdssn eglqsmiqcl lvvsldikqq 121 fqarkilkqi vvftdnlddl ditdeeidll teelstriil idcgkdtqee rkksnwlklv 181 eaipnsriyn mnellveits patsvvkpvr vfsgelrlga dilstqtsnp sgsmqdencl 241 cikveafpat kavsglnrkt avevedsqkk eryvgvksii eyeihnegnk knvseddqsg 301 ssyipvtisk dsvtkayryg adyvvlpsvl vdqtvyesfp gldlrgflnr ealpryflts 361 essfitadtr lgcqsdlmaf salvdvmlen rkiavaryvs kkdsevnmca lcpvliehsn 421 insekkfvks ltlcrlpfae dervtdfpkl ldrtttsgvp lkketdghqi delmeqfvds 481 mdtdelpeip lgnyyqpige vttdttlplp slnkdqeenk kdplriptvf vyrqqqvlle 541 wihqlminds refeipelpd slknkispyt hkkfdstklv evlgikkvdk lkldselkte 601 lerekipdle tllkrgeqhs rgspnnsnn // LOCUS NP_001418070 87 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR106W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001418070 VERSION NP_001418070.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001431141.1 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DBA54441. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..87 /product="uncharacterized protein" /calculated_mol_wt="9472" CDS 1..87 /locus_tag="YMR106W-A" /coded_by="NM_001431141.1:1..264" /note="hypothetical protein; may have been brought into S. cerevisiae genome via horizontal transfer mediated by Ty1 retrotransposition" /db_xref="GeneID:91000624" /db_xref="SGD:S000350097" ORIGIN 1 mismeainnf iktapkhdyl tggvhhsgnv dvlqlsgnke dgslvwnhtf vdvdnnvvak 61 fedalekles lhrrsssstg neehanv // LOCUS NP_013825 115 aa linear PLN 30-JUN-2025 DEFINITION Spg4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013825 VERSION NP_013825.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182607.1 REFERENCE 1 (residues 1 to 115) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 115) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 115) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 115) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10004. Method: conceptual translation. FEATURES Location/Qualifiers source 1..115 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..115 /product="Spg4p" /calculated_mol_wt="13049" Region 3..114 /region_name="SPG4" /note="Stationary phase protein 4; pfam17325" /db_xref="CDD:407431" CDS 1..115 /gene="SPG4" /locus_tag="YMR107W" /coded_by="NM_001182607.1:1..348" /note="Protein required for high temperature survival during stationary phase; not required for growth on nonfermentable carbon sources" /db_xref="GeneID:855134" /db_xref="SGD:S000004713" ORIGIN 1 mgsfwdafav ydkkkhadps vyggnhnntg dsktqvmfsk eyrqprthqq enlqsmrrss 61 igsqdssdve dvkegrlpae veipknvdis nmsqgeflrl yeslrrgepd nkvnr // LOCUS NP_013826 687 aa linear PLN 30-JUN-2025 DEFINITION acetolactate synthase catalytic subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_013826 VERSION NP_013826.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182608.1 REFERENCE 1 (residues 1 to 687) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 687) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 687) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 687) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 687) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10005. Method: conceptual translation. FEATURES Location/Qualifiers source 1..687 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..687 /product="acetolactate synthase catalytic subunit" /EC_number="2.2.1.6" /calculated_mol_wt="74806" Region 92..668 /region_name="acolac_lg" /note="acetolactate synthase, large subunit, biosynthetic type; TIGR00118" /db_xref="CDD:272915" CDS 1..687 /gene="ILV2" /locus_tag="YMR108W" /gene_synonym="SMR1; THI1" /coded_by="NM_001182608.1:1..2064" /experiment="EXISTENCE:direct assay:GO:0003984 acetolactate synthase activity [PMID:10213630]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005948 acetolactate synthase complex [PMID:10213630]" /experiment="EXISTENCE:direct assay:GO:0009082 branched-chain amino acid biosynthetic process [PMID:2406721]" /experiment="EXISTENCE:direct assay:GO:0050660 flavin adenine dinucleotide binding [PMID:15709745]" /experiment="EXISTENCE:mutant phenotype:GO:0009082 branched-chain amino acid biosynthetic process [PMID:2406721]" /note="Acetolactate synthase; catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control" /db_xref="GeneID:855135" /db_xref="SGD:S000004714" ORIGIN 1 mirqstlknf aikrcfqhia yrntpamrsv alaqrfysss sryysasplp askrpepaps 61 fnvdpleqpa epsklakklr aepdmdtsfv gltggqifne mmsrqnvdtv fgypggailp 121 vydaihnsdk fnfvlpkheq gaghmaegya rasgkpgvvl vtsgpgatnv vtpmadafad 181 gipmvvftgq vptsaigtda fqeadvvgis rsctkwnvmv ksveelplri neafeiatsg 241 rpgpvlvdlp kdvtaailrn piptkttlps nalnqltsra qdefvmqsin kaadlinlak 301 kpvlyvgagi lnhadgprll kelsdraqip vtttlqglgs fdqedpksld mlgmhgcata 361 nlavqnadli iavgarfddr vtgniskfap earraaaegr ggiihfevsp kninkvvqtq 421 iavegdattn lgkmmskifp vkersewfaq inkwkkeypy aymeetpgsk ikpqtvikkl 481 skvandtgrh vivttgvgqh qmwaaqhwtw rnphtfitsg glgtmgyglp aaigaqvakp 541 eslvididgd asfnmtltel ssavqagtpv kililnneeq gmvtqwqslf yehryshthq 601 lnpdfiklae amglkglrvk kqeeldaklk efvstkgpvl levevdkkvp vlpmvaggsg 661 ldefinfdpe verqqtelrh krtggkh // LOCUS NP_013827 1219 aa linear PLN 30-JUN-2025 DEFINITION myosin 5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013827 VERSION NP_013827.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182609.1 REFERENCE 1 (residues 1 to 1219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1219) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10006. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1219 /product="myosin 5" /calculated_mol_wt="136769" Region 1..1186 /region_name="COG5022" /note="Myosin heavy chain [General function prediction only]" /db_xref="CDD:227355" CDS 1..1219 /gene="MYO5" /locus_tag="YMR109W" /coded_by="NM_001182609.1:1..3660" /experiment="EXISTENCE:direct assay:GO:0000146 microfilament motor activity [PMID:16824951]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:16824951|PMID:20647997]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:16824951]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0009651 response to salt stress [PMID:12391157]" /experiment="EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:18177206]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:16824951]" /experiment="EXISTENCE:mutant phenotype:GO:0006898 receptor-mediated endocytosis [PMID:8614799]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:18177206]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:35101986]" /experiment="EXISTENCE:mutant phenotype:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:16824951]" /experiment="EXISTENCE:physical interaction:GO:0009651 response to salt stress [PMID:12391157]" /note="One of two type I myosin motors; involved in clathrin-mediated endocytosis; activation by TEDS site phosphorylation increases actin gliding, motor activity and ligand-induced endocytosis; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO5 has a paralog, MYO3, that arose from the whole genome duplication" /db_xref="GeneID:855136" /db_xref="SGD:S000004715" ORIGIN 1 mailkrgark kvhqepakrs anikkatfds skkkevgvsd ltllskisde ainenlkkrf 61 lnatiytyig hvlisvnpfr dlgiytdavm neykgknrle vpphvfaiae smyynmksyn 121 enqcviisge sgagkteaak rimqyiaaas sthtesigki kdmvlatnpl lesfgcaktl 181 rnnnssrhgk yleikfnnqf epcagnitny llekqrvvsq iknernfhif yqftkgasda 241 yrqtfgvqkp eqyvytaaag cisaetiddl qdyqetlkam rviglgqeeq dqifrmlaai 301 lwignvsfie neegnaqvrd tsvtdfvayl lqidsqllik slverimetn hgmkrgsvyh 361 vplnivqada vrdalakaiy nnlfdwivsr vnkslqafpg aeksigildi ygfeifehns 421 feqicinyvn eklqqifiql tlkseqetye rekiqwtpik yfdnkvvcdl iearrppgif 481 aamndsvata hadsnaadqa faqrlnlftt nphfdlrsnk fvikhyagdv tydidgitdk 541 nkdqlqkdlv eligtttntf latifpdtvd reskrrppta gdkiiksand lvetlskaqp 601 syirtikpne tkspndyddr qvlhqikylg lqenvrirra gfayrqvfek fverfyllsp 661 hcsyagdytw qgdtldavky ilqdssipqq eyqlgvtsvf iktpetlfal ehmrdrywhn 721 maariqrawr rflqrridaa tkiqrtirer kegnkyeklr dygtkvlggr kerrsmsllg 781 yrafmgdyls cneskskgay ikrqvsikek vifsihgeal htkfgrsaqr lkktflltpt 841 tlyivgqtlv qnamtytqdy kidvrniqav sltnlqddwv aiklassgqp dplintyfkt 901 elithlkrln dkiqikigsa ieyqkkpgkl hsvkcqines apkygdiyks stisvrrgnp 961 pnsqvhkkpr kkssissgyh asssqatrrp vsiaaaqhvp tapasrhskk pappppgmqn 1021 kaatrrsvpn pastltasqs narpspptaa tratpaatpa aaamgsgrqa nipppppppp 1081 psskpkepmf eaaydfpgsg spselplkkg dviyitreep sgwslgklld gskegwvpta 1141 ymkphsgnnn iptppqnrdv pkpvlnsvqh dntsanvipa aaqaslgdgl analaarank 1201 mrlesddeea nedeeeddw // LOCUS NP_013828 532 aa linear PLN 30-JUN-2025 DEFINITION hexadecenal dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013828 VERSION NP_013828.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182610.1 REFERENCE 1 (residues 1 to 532) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 532) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 532) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 532) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10007. Method: conceptual translation. FEATURES Location/Qualifiers source 1..532 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..532 /product="hexadecenal dehydrogenase" /EC_number="1.2.1.3" /EC_number="1.2.1.64" /calculated_mol_wt="59848" Region 11..466 /region_name="ALDH-SF" /note="NAD(P)+-dependent aldehyde dehydrogenase superfamily; cl11961" /db_xref="CDD:448367" Site order(135..139,147,162,164..165,212..215,218,221..222, 236..238,273,369,371,398,438) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:143453" Site order(139,236,270,273) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:143453" CDS 1..532 /gene="HFD1" /locus_tag="YMR110C" /coded_by="NM_001182610.1:1..1599" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:16689936]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006081 aldehyde metabolic process [PMID:22633490]" /experiment="EXISTENCE:mutant phenotype:GO:0006665 sphingolipid metabolic process [PMID:22633490]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:33862086|PMID:27693056|PMID:27669165]" /experiment="EXISTENCE:mutant phenotype:GO:0018484 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity [PMID:33862086|PMID:27669165|PMID:27693056]" /experiment="EXISTENCE:mutant phenotype:GO:0046185 aldehyde catabolic process [PMID:25545362]" /experiment="EXISTENCE:mutant phenotype:GO:0047770 carboxylate reductase activity [PMID:22633490]" /note="Dehydrogenase involved in ubiquinone and sphingolipid metabolism; converts 4-hydroxybenzaldehyde into 4-hydroxybenzoate for ubiquinone anabolism, hexadecenal to hexadecenoic acid in sphingosine 1-phosphate catabolism; human homolog ALDH3A2, mutated in Sjogren-Larsson syndrome, can rescue yeast hfd1 mutant; human ALDH3A1, but not ALDH3A2, rescues pABA- respiratory growth phenotype of hfd1 null; data suggest that dual functions of Hfd1p have diverged in human ALDH3A1, ALDH3A2" /db_xref="GeneID:855137" /db_xref="SGD:S000004716" ORIGIN 1 msndgskiln ytpvskidei veisrnfffe kqlklshenn prkkdlefrq lqlkklyyav 61 kdheeelida mykdfhrnki esvlnettkl mndilhliei lpklikprrv sdssppfmfg 121 ktivekisrg svliiapfnf plllafapla aalaagntiv lkpseltpht avvmenlltt 181 agfpdgliqv vqgaidettr lldcgkfdli fytgsprvgs ivaekaaksl tpcvlelggk 241 sptfitenfk asnikialkr iffgafgnsg qicvspdyll vhksiypkvi kecesvlnef 301 ypsfdeqtdf trmihepayk kavasinstn gskivpskis insdtedlcl vpptivynig 361 wddplmkqen fapvlpiiey edldetinki ieehdtplvq yifsdsqtei nriltrlrsg 421 dcvvgdtvih vgitdapfgg igtsgygnyg gyygfntfsh ertifkqpyw ndftlfmryp 481 pnsaqkeklv rfamerkpwf drngnnkwgl rqyfslsaav ilistiyahc ss // LOCUS NP_013829 462 aa linear PLN 30-JUN-2025 DEFINITION Euc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013829 VERSION NP_013829.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182611.1 REFERENCE 1 (residues 1 to 462) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 462) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 462) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 462) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10008. Method: conceptual translation. FEATURES Location/Qualifiers source 1..462 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..462 /product="Euc1p" /calculated_mol_wt="52239" Region 296..385 /region_name="GCR1_C" /note="Transcriptional activator of glycolytic enzymes; pfam12550" /db_xref="CDD:432628" CDS 1..462 /gene="EUC1" /locus_tag="YMR111C" /coded_by="NM_001182611.1:1..1389" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:31015336]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:31015336]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:31015336]" /note="Sequence-specific DNA binding protein; binds to a sequence motif associated with distinct genomic hotspots of non-H2B protein ubiquitylation (ub-hotspots); interacts with Slx5p to recruit the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex to ub-hotspots; deletion prevents ub-hotspot formation and exacerbates heat sensitivity of cells deficient in Rpd3L histone deacetylase complex members; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:855138" /db_xref="SGD:S000004717" ORIGIN 1 mpareynyve gfggygsldd ddsdrdserr nhdlgqrtit tsptgvsrha alnrymipgr 61 inplfrptda aqppivstst sasateptnr igpgriketp etnfnaflia qltrmeeqna 121 nlkeeislmk keqelfflen qkklekgfkd inkyvedvsa mkevfkevvg imtgerirfi 181 dhtgenvtpq eaarvgnpst stqahqsqsr stnwqeysmh asilagdpri kpepglsdfe 241 ngeydgnesd enattrnlpl nnpdsvsnad dsnnqldgtg nendirnrrg cvgtsyklnr 301 aiqnvtdaar eyfeglpgqp svlslerryg stwrrsaker tlftkrmtii kriidikddp 361 skyglslpen kisrnqaikv venirlgnnt fkghhcrlsm sqlyeyfskk mdkledyslt 421 lkrrgkprri flleerearl slqqphsipn sstgtpehdq dt // LOCUS NP_013830 131 aa linear PLN 30-JUN-2025 DEFINITION Med11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013830 VERSION NP_013830.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182612.1 REFERENCE 1 (residues 1 to 131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 131) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10009. Method: conceptual translation. FEATURES Location/Qualifiers source 1..131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..131 /product="Med11p" /calculated_mol_wt="15038" Region 23..125 /region_name="Med11" /note="Mediator complex protein; pfam10280" /db_xref="CDD:463042" CDS 1..131 /gene="MED11" /locus_tag="YMR112C" /coded_by="NM_001182612.1:1..396" /experiment="EXISTENCE:direct assay:GO:0001097 TFIIH-class transcription factor complex binding [PMID:18691966]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:18691966]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:18691966]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein" /db_xref="GeneID:855139" /db_xref="SGD:S000004718" ORIGIN 1 mqvlntkset kqenetmqpp yiqerlksln dietqlcsml qeasqvtfif gelkrgnesv 61 kpqfenhvkq fyerldkstt qlrkeiqlld envgtrllpi nvnkkalgqd tekmeeqldl 121 lsaildpsks k // LOCUS NP_013831 427 aa linear PLN 30-JUN-2025 DEFINITION dihydrofolate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013831 VERSION NP_013831.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182613.1 REFERENCE 1 (residues 1 to 427) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 427) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 427) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 427) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 427) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10010. Method: conceptual translation. FEATURES Location/Qualifiers source 1..427 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..427 /product="dihydrofolate synthase" /EC_number="6.3.2.12" /calculated_mol_wt="47720" Region 7..421 /region_name="folC" /note="folylpolyglutamate synthase/dihydrofolate synthase; TIGR01499" /db_xref="CDD:273659" CDS 1..427 /gene="FOL3" /locus_tag="YMR113W" /coded_by="NM_001182613.1:1..1284" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008841 dihydrofolate synthase activity [PMID:11731153]" /experiment="EXISTENCE:mutant phenotype:GO:0009396 folic acid-containing compound biosynthetic process [PMID:11731153]" /note="Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis; FOL3 has a paralog, RMA1, that arose from the whole genome duplication" /db_xref="GeneID:855140" /db_xref="SGD:S000004719" ORIGIN 1 maielglsri tkllehlgnp qnslrvlhia gtngkgsvct ylssvlqqks yqigkfttph 61 lvhvtdsiti nnkpiplery qnirlqleal nkshslkcte felltctafk yfydvqcqwc 121 vievglggrl datnvipgan kaccgitkis ldhesflgnt lseiskekag iitegvpftv 181 idgtneasvi nvvkerckal gselsvtdsq lngnmidtns wgcfdlaklp lngeyqifnl 241 rvamgmldyl qmneliditk nevstrlakv dwpgrlyrmd yrfdkvsnrt vpilmdgahn 301 gsaavelvky lrkeygnqpl tfvmavthgk nlepllqpll rpidqviltr fnnvegmpwi 361 hatdpeeikd filtqgytke iviendlhqv lpslahvsde qrrpivvcgs lylcgellri 421 hnshlrn // LOCUS NP_013832 368 aa linear PLN 30-JUN-2025 DEFINITION putative peptide hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013832 VERSION NP_013832.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182614.1 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10011. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..368 /product="putative peptide hydrolase" /calculated_mol_wt="42770" Region 1..239 /region_name="SRAP" /note="SOS response associated peptidase (SRAP); pfam02586" /db_xref="CDD:460605" CDS 1..368 /locus_tag="YMR114C" /coded_by="NM_001182614.1:1..1107" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:24390141]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene" /db_xref="GeneID:855141" /db_xref="SGD:S000004720" ORIGIN 1 mcgrfalayd sgdlpqllrd wnlpvntpkd assnsqhphd eedtkdqptv skdifkasyn 61 isptnysavy rpdtkaiqfm rwglvpfwtk dvsqfktyrt fnarlenlqe skmwmrpcek 121 krcavlmsgy fewktvgkkk tpyfisrrdg rlmfvagmyd yvekddlytf tiitaqgpre 181 lewlhermpc vlepgteswd awmdvdkttw steelvkllk pdydesklqf yqvtddvgkt 241 tntgerlikp llkedsdmfs vkrekeeall endneqgidn rgvkgdkslk gedvfnqkks 301 lkrnsydglk kneeqeettl peegsigdrv kreeanlspk regnrekrni vnmlgnqkds 361 rgkkkikk // LOCUS NP_013833 501 aa linear PLN 30-JUN-2025 DEFINITION Mgr3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013833 VERSION NP_013833.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182615.1 REFERENCE 1 (residues 1 to 501) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 501) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 501) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 501) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10012. Method: conceptual translation. FEATURES Location/Qualifiers source 1..501 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..501 /product="Mgr3p" /calculated_mol_wt="57873" Region 102..488 /region_name="Mgr3-like" /note="Mitochondrial inner membrane i-AAA protease supercomplex subunit Mgr3 and similar proteins; cd24145" /db_xref="CDD:467945" CDS 1..501 /gene="MGR3" /locus_tag="YMR115W" /gene_synonym="FMP24" /coded_by="NM_001182615.1:1..1506" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:18843051]" /experiment="EXISTENCE:direct assay:GO:0031942 i-AAA complex [PMID:18843051]" /experiment="EXISTENCE:direct assay:GO:0051787 misfolded protein binding [PMID:18843051]" /experiment="EXISTENCE:mutant phenotype:GO:0141164 mitochondrial protein quality control [PMID:18843051]" /note="Subunit of the mitochondrial (mt) i-AAA protease supercomplex; i-AAA degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA" /db_xref="GeneID:855142" /db_xref="SGD:S000004721" ORIGIN 1 mllqgmrlsq rlhkrhlfas kiltwttnpa hirhlhdirp pasnfntqes apipespans 61 ptrpqmapkp nlkkknrslm ysiigvsivg lyfwfksnsr kqklplsaqk vwkeaiwqes 121 dkmdfnykea lrryiealde cdrshvdlls ddytrielki aemyeklnml eeaqnlyqel 181 lsrffealnv pgkvdeserg evlrkdlril iksleinkdi esgkrkllqh lllaqeeils 241 kspelkeffe nrkkklsmvk dinrdpnddf ktfvseenik fdeqgymild leknssawep 301 fkeefftard lytayclssk diaaalscki tsvewmvmad mppgqillsq anlgslfylq 361 aekleadlnq leqkkskesn qeldmgtyik avrfvrknrd lcleraqkcy dsviafakrn 421 rkirfhvkdq ldpsiaqsia lstygmgvls lhegvlakae klfkdsitma ketefnella 481 eaekelektt vlkaakkegl n // LOCUS NP_013834 319 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein RACK1 ASC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013834 VERSION NP_013834.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182616.1 REFERENCE 1 (residues 1 to 319) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 319) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 319) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 319) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10013. Method: conceptual translation. FEATURES Location/Qualifiers source 1..319 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..319 /product="40S ribosomal protein RACK1 ASC1" /calculated_mol_wt="34674" Region 9..314 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(16,35,39,45..46,63..64,82,86,92..93,105..106,123,128, 134,147,170,175,181..182,194..195,213,217,223..224, 236..237,253,258,263..264,284..285,303,307,313..314) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 20..63 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 69..105 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 110..145 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 152..193 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 199..235 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 240..283 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 290..313 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..319 /gene="ASC1" /locus_tag="YMR116C" /gene_synonym="ASU9; CPC2; NAD1" /coded_by="NM_001182616.1:1..960" /experiment="EXISTENCE:direct assay:GO:0005092 GDP-dissociation inhibitor activity [PMID:17591772]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:15340087]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:27821475]" /experiment="EXISTENCE:mutant phenotype:GO:0006521 regulation of amino acid metabolic process [PMID:34214075]" /experiment="EXISTENCE:mutant phenotype:GO:0007186 G protein-coupled receptor signaling pathway [PMID:17591772]" /experiment="EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:31532761]" /experiment="EXISTENCE:mutant phenotype:GO:0017148 negative regulation of translation [PMID:15340087]" /experiment="EXISTENCE:mutant phenotype:GO:0061157 mRNA destabilization [PMID:31532761]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:28956756]" /experiment="EXISTENCE:mutant phenotype:GO:1902660 negative regulation of glucose mediated signaling pathway [PMID:17591772]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:30465652]" /experiment="EXISTENCE:mutant phenotype:GO:2001125 negative regulation of translational frameshifting [PMID:25792604]" /experiment="EXISTENCE:physical interaction:GO:0001965 G-protein alpha-subunit binding [PMID:17591772]" /experiment="EXISTENCE:physical interaction:GO:0007186 G protein-coupled receptor signaling pathway [PMID:17591772]" /experiment="EXISTENCE:physical interaction:GO:1902660 negative regulation of glucose mediated signaling pathway [PMID:17591772]" /note="G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; required to prevent frameshifting at ribosomes stalled at repeated CGA codons; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; controls phosphorylation of multiple proteins" /db_xref="GeneID:855143" /db_xref="SGD:S000004722" ORIGIN 1 masnevlvlr gtleghngwv tslatsagqp nlllsasrdk tliswkltgd dqkfgvpvrs 61 fkghshivqd ctltadgaya lsaswdktlr lwdvatgety qrfvghksdv msvdidkkas 121 miisgsrdkt ikvwtikgqc latllghndw vsqvrvvpne kadddsvtii sagndkmvka 181 wnlnqfqiea dfighnsnin tltaspdgtl iasagkdgei mlwnlaakka mytlsaqdev 241 fslafspnry wlaaatatgi kvfsldpqyl vddlrpefag yskaaephav slawsadgqt 301 lfagytdnvi rvwqvmtan // LOCUS NP_013835 213 aa linear PLN 30-JUN-2025 DEFINITION kinetochore-associated Ndc80 complex subunit SPC24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013835 VERSION NP_013835.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182617.1 REFERENCE 1 (residues 1 to 213) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 213) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 213) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 213) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10014. Method: conceptual translation. FEATURES Location/Qualifiers source 1..213 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..213 /product="kinetochore-associated Ndc80 complex subunit SPC24" /calculated_mol_wt="24473" Region 91..210 /region_name="Spc24" /note="Spc24 subunit of Ndc80; pfam08286" /db_xref="CDD:429899" CDS 1..213 /gene="SPC24" /locus_tag="YMR117C" /coded_by="NM_001182617.1:1..642" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11511347]" /experiment="EXISTENCE:direct assay:GO:0031262 Ndc80 complex [PMID:11266451|PMID:11179222]" /experiment="EXISTENCE:mutant phenotype:GO:0000776 kinetochore [PMID:11179222]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11266451]" /experiment="EXISTENCE:mutant phenotype:GO:0098653 centromere clustering [PMID:11179222]" /note="Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p" /db_xref="GeneID:855144" /db_xref="SGD:S000004723" ORIGIN 1 msqkdnlldn pveflkevre sfdiqqdvda mkrirhdldv ikeesearis kehskvsesn 61 kklnaerinv aklegdleyt neesnefgsk delvkllkdl dglernivsl rseldekmkl 121 ylkdseiist pngskikakv iepeleeqsa vtpeanenil klklyrslgv ildlendqvl 181 inrkndgnid ilpldnnlsd fyktkyiwer lgk // LOCUS NP_013836 196 aa linear PLN 30-JUN-2025 DEFINITION protein SHH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013836 VERSION NP_013836.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182618.1 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10015. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..196 /product="protein SHH3" /calculated_mol_wt="22178" Region 73..195 /region_name="SQR_TypeC_SdhC" /note="Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; cd03499" /db_xref="CDD:239579" Site order(73..76,81..83,85,88,95,161,164,166) /site_type="active" /note="Iron-sulfur protein interface [active]" /db_xref="CDD:239579" Site order(84,91..92,95) /site_type="other" /note="proximal quinone binding site [chemical binding]" /db_xref="CDD:239579" Site order(95,106,109,112..113,124,144,165,193) /site_type="other" /note="SdhD (CybS) interface [polypeptide binding]" /db_xref="CDD:239579" Site order(95,101..102,154..155) /site_type="other" /note="proximal heme binding site [chemical binding]" /db_xref="CDD:239579" CDS 1..196 /gene="SHH3" /locus_tag="YMR118C" /coded_by="NM_001182618.1:1..591" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /note="Putative mitochondrial inner membrane hypothetical protein; although similar to paralogous Sdh3p, Shh3p is not a stoichiometric subunit of either succinate dehydrogenase or of the TIM22 translocase; SHH3 has a paralog, SDH3, that arose from the whole genome duplication" /db_xref="GeneID:855145" /db_xref="SGD:S000004724" ORIGIN 1 mkatiqrvts vfgvprasvf vpristpfil hnyisngrmd lfskefhngr vsksdlwssn 61 keeellvsqr kkrpisphlt vyepemswyl sslhrisgvl lalgfyafti tlgvttimgm 121 dttfqdlnkw yhekmpkwsq wvakgsaayl fafhfgngir hliwdmgyel tnrgviktgs 181 ivlagtlvlg tyllaq // LOCUS NP_013837 624 aa linear PLN 30-JUN-2025 DEFINITION putative ubiquitin-protein ligase ASI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013837 VERSION NP_013837.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182619.1 REFERENCE 1 (residues 1 to 624) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 624) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 624) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 624) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10016. Method: conceptual translation. FEATURES Location/Qualifiers source 1..624 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..624 /product="putative ubiquitin-protein ligase ASI1" /EC_number="2.3.2.27" /calculated_mol_wt="71313" Region 565..617 /region_name="mRING-HC-C4C4_Asi1p-like" /note="Modified RING finger, HC subclass (C4C4-type), found in Saccharomyces cerevisiae amino acid sensor-independent protein Asi1p, Asi3p and similar proteins; cd16616" /db_xref="CDD:438278" CDS 1..624 /gene="ASI1" /locus_tag="YMR119W" /coded_by="NM_001182619.1:1..1875" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:16735580|PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0097658 Asi complex [PMID:25236469]" /experiment="EXISTENCE:genetic interaction:GO:0004842 ubiquitin-protein transferase activity [PMID:11454748]" /experiment="EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11454748]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:25236469]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25236469]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:25253722]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:17085444]" /note="Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids" /db_xref="GeneID:855147" /db_xref="SGD:S000004725" ORIGIN 1 mnsstssenv finsfsylnq tsqavisgns tfanvinfpy rlglsfigav nlqyeqtvks 61 eeipptlrsv fdtigfffsp yaifcfviai vlnrfvvfya vlnngsrrtl plwlsnvfhv 121 savvvlamvs lgpltlgkdf kilgdpafaq ekfllnifya faysycveti ftimrnsspl 181 egtdyslfel siqfytmtnn ntkfldspdy iidcsmails rilihlveif rlrnyrllfs 241 timnlchicy lgirvkqggw kslpfsvkfr hfpklfsvsi iclsllifkl sclirwdpfg 301 ksrnscellq fyplsrnwkk ylnytgeedf samatkfall lcsgtelmek girrefpain 361 ipdnvnekff isgylnelsk pykentsisf pkknssilkq rfflmfpksi iwimkklvgq 421 vffgfrdnkd edipdndpsk mlkitktnsl nnsaghkedi elellntsdd eysedyepse 481 veslgdsdee nleedslifn etrdalldlf ssednevhtd ynwimstsri lqqkllsdkt 541 ltrasildtk lsevdetfgt esdfdlscav ckvnerntvl wpcrcfaice dcrislglrg 601 fstcvccrsk vhgyckvhpv sdsk // LOCUS NP_013839 592 aa linear PLN 30-JUN-2025 DEFINITION bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013839 VERSION NP_013839.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182621.1 REFERENCE 1 (residues 1 to 592) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 592) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 592) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 592) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10017. Method: conceptual translation. FEATURES Location/Qualifiers source 1..592 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..592 /product="bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase ADE17" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /calculated_mol_wt="65132" Region 6..546 /region_name="purH" /note="phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGR00355" /db_xref="CDD:273032" CDS 1..592 /gene="ADE17" /locus_tag="YMR120C" /coded_by="NM_001182621.1:1..1779" /experiment="EXISTENCE:direct assay:GO:0003937 IMP cyclohydrolase activity [PMID:10877846]" /experiment="EXISTENCE:direct assay:GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity [PMID:10877846]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10877846]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0006164 purine nucleotide biosynthetic process [PMID:10877846]" /experiment="EXISTENCE:direct assay:GO:0006189 'de novo' IMP biosynthetic process [PMID:10877846]" /experiment="EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:10877846]" /experiment="EXISTENCE:mutant phenotype:GO:0006189 'de novo' IMP biosynthetic process [PMID:10877846]" /note="Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE17 has a paralog, ADE16, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine" /db_xref="GeneID:855149" /db_xref="SGD:S000004727" ORIGIN 1 manytktail svydktglld larglieknv rilasggtar mirdagfpie dvsaithape 61 mlggrvktlh pavhggilar didsdekdlk eqhiekvdyv vcnlypfket vakvgvtipe 121 aveeidiggv tllraaaknh arvtilsdpk dyseflsels sngeisqdlr nrlalkafeh 181 tadydaaisd ffrkqysegq aqitlrygan phqkpaqayv sqqdslpfkv lcgspgyinl 241 ldalnswplv kelsaslnlp aaasfkhvsp agaavgipls dvekqvyfva dienlsplac 301 ayarargadr mssfgdwial snivdvptak iisrevsdgv iapgyepeal ailskkkggk 361 ycilqidpny vpeaverrqv ygvtleqkrn daiinqstfk eivsqnknlt eqaiidltva 421 tiaikytqsn svcyarngmv vglgagqqsr ihctrlagdk adnwwfrqhp rvleikwakg 481 vkrpeksnai dlfvtgqipt eepelseyqs kfeeipkpft peerkewlsk ltnvslssda 541 ffpfpdnvyr avksgvkyia apsgsvmdkv vfsaadsfdl vyvenpirlf hh // LOCUS NP_013840 204 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL15 RPL15B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013840 VERSION NP_013840.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182622.1 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10018. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..204 /product="60S ribosomal protein eL15 RPL15B" /calculated_mol_wt="24291" Region 1..203 /region_name="PTZ00026" /note="60S ribosomal protein L15; Provisional" /db_xref="CDD:185402" CDS 1..204 /gene="RPL15B" /locus_tag="YMR121C" /coded_by="NM_001182622.1:1..615" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /note="Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress" /db_xref="GeneID:855150" /db_xref="SGD:S000004728" ORIGIN 1 mgaykyleel erkkqsdvlr flqrvrvwey rqknvihraa rptrpdkarr lgykakqgfv 61 iyrvrvrrgn rkrpvpkgat ygkptnqgvn elkyqrslra taeervgrra anlrvlnsyw 121 vnqdstykyf evilvdpqhk airrdarynw icnpvhkhre argltatgkk srginkghkf 181 nntkagrrkt wkrqntlslw ryrk // LOCUS NP_001335807 124 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR122C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335807 VERSION NP_001335807.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348867.1 REFERENCE 1 (residues 1 to 124) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 124) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 124) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 124) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80327. Method: conceptual translation. FEATURES Location/Qualifiers source 1..124 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..124 /product="uncharacterized protein" /calculated_mol_wt="14015" CDS 1..124 /locus_tag="YMR122C" /coded_by="NM_001348867.1:1..375" /note="hypothetical protein; conserved among S. cerevisiae strains; YMR122C is not an essential gene" /db_xref="GeneID:855151" /db_xref="SGD:S000004729" ORIGIN 1 mlrqfggvfr nlrvpertna llfaqhkgde rhsgqrafdg skfrleakrc ftaiciitva 61 rrdrlgvlvc gkntastlpy lpanrifrlp kvqirkmfpi gcatflsrey iitallvsyc 121 hlcv // LOCUS NP_061493 84 aa linear PLN 30-JUN-2025 DEFINITION Ncw1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_061493 VERSION NP_061493.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184445.1 REFERENCE 1 (residues 1 to 84) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 84) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 84) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 84) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10019. Method: conceptual translation. FEATURES Location/Qualifiers source 1..84 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..84 /product="Ncw1p" /calculated_mol_wt="7850" CDS 1..84 /gene="NCW1" /locus_tag="YMR122W-A" /coded_by="NM_001184445.1:1..255" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum" /db_xref="GeneID:855152" /db_xref="SGD:S000007524" ORIGIN 1 masststsas asssiktnsa lvsnnvvaas svsatstass saaknttsss knaapgmvan 61 pvsskygiim aafaavsfvl gtgi // LOCUS NP_013842 122 aa linear PLN 30-JUN-2025 DEFINITION Pkr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013842 VERSION NP_013842.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182624.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10020. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..122 /product="Pkr1p" /calculated_mol_wt="13831" Region 4..73 /region_name="Pkr1" /note="ER protein Pkr1; pfam08636" /db_xref="CDD:430120" CDS 1..122 /gene="PKR1" /locus_tag="YMR123W" /coded_by="NM_001182624.1:1..369" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:16926153]" /experiment="EXISTENCE:genetic interaction:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:16926153]" /experiment="EXISTENCE:mutant phenotype:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:16926153]" /note="V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855153" /db_xref="SGD:S000004730" ORIGIN 1 manffvrlwe svfepgtspq liiathvsfv allltliwli yatngnihfy alfcislllw 61 itviwfinel shvklkdnde ldkdankkdd saikedsedk qesgkststa rrtqaqsrsr 121 ka // LOCUS NP_013843 943 aa linear PLN 30-JUN-2025 DEFINITION Epo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013843 VERSION NP_013843.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182625.1 REFERENCE 1 (residues 1 to 943) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 943) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 943) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 943) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 943) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 943) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 943) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10021. Method: conceptual translation. FEATURES Location/Qualifiers source 1..943 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..943 /product="Epo1p" /calculated_mol_wt="105783" Region <808..>942 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" CDS 1..943 /gene="EPO1" /locus_tag="YMR124W" /coded_by="NM_001182625.1:1..2832" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0061163 endoplasmic reticulum polarization [PMID:25083872]" /experiment="EXISTENCE:physical interaction:GO:0005935 cellular bud neck [PMID:25083872]" /note="Protein involved in septin-ER tethering; interacts with ER membrane protein, Scs2p, and Shs1p, a septin ring component, at bud neck to create ER diffusion barrier; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W has a paralog, YLR031W, that arose from the whole genome duplication" /db_xref="GeneID:855154" /db_xref="SGD:S000004731" ORIGIN 1 mdaglstmat rngqssarvk lrnnllnndi gnidirdetp isrngndsni niqpssvpqq 61 qqqqqqyyrn gmneapiqap lqqrqipmqn ysqqqrqqqq ynfeysnphm neiplmqhnf 121 tkpslsnnrd nvngkkassf tqssfsnffk hkhqfgkskk ntkgtggggd gddddevild 181 dsansdltfn diqtfghkgg dkygyggdst piiptlvtkd rgnmsnteyr kyitnqrkta 241 mnamakqtkn gtlaslppra mslqsfpngn plmqaptphp rfqpnkmvsa nysrsnslms 301 gppgqfrqpq qqrmlpmnny nnhpgqfqnt ppvmpsgqqp pqqprtlslt ngpryspqnp 361 rpfaghqqis qrqqqqqqql qlhpmsegyr tmslqsqnvp qgfnpwspnd ndrkavsmkq 421 pisqssissk nnsaysipnv qnnslttfsp ssptdatamp nstkqgsspl kkqvnidqpi 481 enkgklnvlq lstpqqnelk ekerklaeme kslrerealv eekekeraek nteaneeeei 541 shesddlnlr pasaletglk dlklesesav anraslstfs stfsdspskq riintrtgmy 601 klenstdine yvtaqefpsp gkynsnsdng emnttnevdf dfntskrasl lqsiperdpk 661 rnvsdatikr resdgngrrl snvnismnqe ninndtflyk knnrdghlsa vshmssssrr 721 sfisntlpln idsasesdnf vphmdgspsk tksapvsydk dgmnaseedf sfdntlakpy 781 eplyarrgdi tsagstsged ssqpkmitis geqlnliten kelmneltlv stelaesikr 841 eteleerirl yetnnsapsf ddsssvsfsd fekelrkkss kivqliqqln derlkrfiae 901 eqlllqengt kpssmelvgr ienlnklide rdseiemlkg rlq // LOCUS NP_013844 861 aa linear PLN 30-JUN-2025 DEFINITION Sto1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013844 VERSION NP_013844.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182626.1 REFERENCE 1 (residues 1 to 861) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 861) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 861) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 861) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10022. On Dec 15, 1999 this sequence version replaced NP_013844.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..861 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..861 /product="Sto1p" /calculated_mol_wt="99887" Region 36..264 /region_name="MIF4G" /note="MIF4G domain; pfam02854" /db_xref="CDD:397130" Region 346..541 /region_name="MIF4G_like" /note="MIF4G like; pfam09088" /db_xref="CDD:370287" Region 581..828 /region_name="MIF4G_like_2" /note="MIF4G like; pfam09090" /db_xref="CDD:462675" CDS 1..861 /gene="STO1" /locus_tag="YMR125W" /gene_synonym="CBC1; CBP80; GCR3; SUT1" /coded_by="NM_001182626.1:1..2586" /experiment="EXISTENCE:direct assay:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:15753296]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005846 nuclear cap binding complex [PMID:8811086]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:22072789]" /experiment="EXISTENCE:physical interaction:GO:0000243 commitment complex [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:10072386]" /experiment="EXISTENCE:physical interaction:GO:0003729 mRNA binding [PMID:10072386]" /note="Large subunit of the nuclear mRNA cap-binding protein complex; interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80" /db_xref="GeneID:855155" /db_xref="SGD:S000004732" ORIGIN 1 mfnrkrrgdf dedenyrdfr prmpkrqrip pvvqlckemm pdirtigesv kafeddikfl 61 seaimneygh edyfnnalls tlnavvveqp qkqaaiallt mvvnsknnva gksiinyffe 121 elqkwckqty ndefkstsne tgpwnkikli lrflsilspm flvdeliniy kslfelsiel 181 nnldpgnrvp lseaiytntl lnipylfffn rnndglrtkv eellayveqn ylvkttdinl 241 lreyngeppy emvelvrvvl pnvkkalinn leqlnelfpd wnhlltpqtg degfndaltl 301 psvddlksfv rlnknfgsvd smwktpryaf hvylpnsagn fetvvpisty agqlfndiii 361 dlveslefnr kevarqvitl dlffkagift epgesiaqli atyeenplap tfkiedlaie 421 tilglifklp svsqpfayfy tllvdicqns pkaiapvfgr afrffyshld sldfelklry 481 ldwfsiqmsn fnfswkwnew eddsikfgky fynpkvnfak nliqkelrlt snfsevedsl 541 pqeftkyldt syiprdqlin yyqslftgyt veedsvrknd lyfrqegvpm entvrkildy 601 thkannsrev telesilgel kneygsiisd fnrfviillv qavtdsgsrs lshankyind 661 lkedlktifa kieldietke yiiieavltf wnanpqtgfl vadafkyagl ltsrtiftfi 721 fnetglknng lieataieav frnlsqqise enesgnnfef vferlctian stidlldvna 781 dedieipkvn gemdiddied dkldlkwkyf tvigfiksil rrysheyrel adkfianidn 841 aiphestrrt isnwiqetke v // LOCUS NP_013845 342 aa linear PLN 30-JUN-2025 DEFINITION Dlt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013845 VERSION NP_013845.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182627.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10023. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..342 /product="Dlt1p" /calculated_mol_wt="39056" CDS 1..342 /gene="DLT1" /locus_tag="YMR126C" /coded_by="NM_001182627.1:1..1029" /note="hypothetical protein; mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)" /db_xref="GeneID:855156" /db_xref="SGD:S000004733" ORIGIN 1 msgfaklksw lykaslfvsl illigfsvvl pidsiaqask sennafntfi vvgalvvfgv 61 fcifiiigrm lfhksclkdi prryipitpa dlphrssrea vlqnmerske ltillkkpkd 121 pvihdglepp rrcdypldek lfpeylnyad ciksltdrlk yhglflnnld vrmnledtfa 181 dvvnsqfvnh nankiqleka kefidlyeti rfsgkdvtrd qfikfvkfcl yfgevsltrd 241 tsfanlhnfr lngssnnigr teskysinpf deneyaqddm hyfpeppthl vressistva 301 rhvssgvdlt nseehpldtd sdcnalrlkl skadsyrsvi rh // LOCUS NP_013846 338 aa linear PLN 30-JUN-2025 DEFINITION histone acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013846 VERSION NP_013846.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182628.1 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10024. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..338 /product="histone acetyltransferase" /EC_number="2.3.1.48" /calculated_mol_wt="39075" Region <31..338 /region_name="SAS2" /note="Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]; COG5027" /db_xref="CDD:227360" CDS 1..338 /gene="SAS2" /locus_tag="YMR127C" /gene_synonym="KAT8" /coded_by="NM_001182628.1:1..1017" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:11731479]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:12626510]" /experiment="EXISTENCE:direct assay:GO:0016407 acetyltransferase activity [PMID:11731479]" /experiment="EXISTENCE:direct assay:GO:0031509 subtelomeric heterochromatin formation [PMID:11731479]" /experiment="EXISTENCE:direct assay:GO:0033255 SAS acetyltransferase complex [PMID:12626510]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:27655944]" /experiment="EXISTENCE:physical interaction:GO:0033255 SAS acetyltransferase complex [PMID:15788653]" /note="Histone acetyltransferase (HAT) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; other members are Sas4p and Sas5p" /db_xref="GeneID:855157" /db_xref="SGD:S000004734" ORIGIN 1 marslsqslt attqklkgkk nggkgknkps akikktqkem lygilnerni rqiqfglnkk 61 fstwygsavy fdpetkrlgc setkgqlssv snsqywldtl fvceycfkyt ddqtrfvghv 121 ascpfqyrvp gkikykspey tirrvkgsky qlfcqclclf tklyldnksm yfkvdhyefy 181 ivyetgstkp mgffskdlvs yqqnnlacil ifppyqrrgl gllliefsyk lsqlegvisg 241 pevplspfgl igylkywsqi lcwhliegdl ahydkvtled lsivtgmrvn dviltlkhln 301 cigennqiyl qslnswlklh gtkrnwfklk deyllidd // LOCUS NP_013847 1267 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase ECM16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013847 VERSION NP_013847.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182629.1 REFERENCE 1 (residues 1 to 1267) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1267) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1267) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1267) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10025. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1267 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1267 /product="ATP-dependent RNA helicase ECM16" /EC_number="3.6.4.13" /calculated_mol_wt="144824" Region 390..>940 /region_name="HrpA" /note="HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; COG1643" /db_xref="CDD:441249" Region 879..1006 /region_name="HA2" /note="Helicase associated domain (HA2); pfam04408" /db_xref="CDD:461295" Region 1080..1184 /region_name="OB_NTP_bind" /note="Oligonucleotide/oligosaccharide-binding (OB)-fold; pfam07717" /db_xref="CDD:400182" CDS 1..1267 /gene="ECM16" /locus_tag="YMR128W" /gene_synonym="DHR1" /coded_by="NM_001182629.1:1..3804" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:10982841]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922|PMID:10982841]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0042254 ribosome biogenesis [PMID:10982841]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16449634]" /note="Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP; functions with methyltransferase Bud23p; required for 18S rRNA synthesis; unwinding activity is activated by Utp14p, and Utp14p acts with Bud23p to recruit the helicase to the assembling preribosome; subject to autoinhibition; predominantly nucleolar in distribution" /db_xref="GeneID:855158" /db_xref="SGD:S000004735" ORIGIN 1 mgtyrkrfne karsghmakl kelkrirnkq ftrqdender venpdsapae ssttepnana 61 eileplteee kkmkkrklqe lftpkeskvs rlkkkrldkf iehqlkreer ktiigklqdy 121 kidtslltss krlgegrqtk keefkealsl erqgrgneqt neilyeeyep kvwdeygegg 181 ssedddgedd feasfgsmpk ptdneekkss gfidhrpakf ggsglsfgfs nikvinkesk 241 tpkkkynwrq rvemeelkkh gkedemdfdt tsedddeeed qeeedkmhps enpleevesa 301 dsetgsekfd qndvanefkd wanqeikkle grdqelvtpt lnidykpiir kedlddglqe 361 ayvpinenst rkafyvevsr sdeiqkariq lpvfgeehki meaihhndvv iicgetgsgk 421 ttqvpqflye agfgaedspd ypgmvgitqp rrvaavsmae rvanelgdhg hkvgyqirfd 481 stakedtkvk fmtdgvllre mmhdfkltky ssiiideahe rnintdilig mlsrcvrlra 541 klhkenpieh kklkliimsa tlrvsdfsen ktlfpiappv lqvdarqfpv sihfnrrtaf 601 nytdeafrkt ckihqklppg ailvfltgqq eithmvkrlr kefpfkknsk ynkdletpvs 661 kmginskttd leaedidfsv qvidqdkfks airyeedegn sgngedeede eeegfeevlt 721 egqtandply vlplysllpt keqmrvfqkp pqgsrlciva tnvaetslti pgvryvvdsg 781 rskerkynes ngvqsfevgw vskasanqrs gragrtgpgh cyrlyssavf ehdfeqfskp 841 eilrmpvesi vlqmksmaih niinfpfptp pdrvalskai qllqylgald nkemitedgk 901 kmslfplspr fskmllvsde kaclpyivai vsalsvgdpf inefelgine isrkpnpden 961 lddkirehde stpgmdpelk kelrskfyks rsqfskldkf sdvfrllsvv samdyvpkeq 1021 keifmkknfl rgklmeeivk lrkqlmyiik sntskeniav virnedlksd ipsviqikll 1081 kqmicagfvd hvavradvlf pddakitnrt siinipyipv latrtpnied cfvyihptsi 1141 lnnlgemppk ymlyyslhlg gnnktrmntl cdiastplan iarkglllty skpltgqglk 1201 tvnlsptery cyvvprfgst vdndlkigwd lnpiavhqkk qkgqwtvikf itrkgfqtit 1261 geekekk // LOCUS NP_013848 1337 aa linear PLN 30-JUN-2025 DEFINITION Pom152p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013848 VERSION NP_013848.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182630.1 REFERENCE 1 (residues 1 to 1337) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1337) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1337) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1337) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1337) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10026. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1337 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1337 /product="Pom152p" /calculated_mol_wt="151522" CDS 1..1337 /gene="POM152" /locus_tag="YMR129W" /coded_by="NM_001182630.1:1..4014" /experiment="EXISTENCE:direct assay:GO:0005641 nuclear envelope lumen [PMID:9988776]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:8138573|PMID:7559775|PMID:9988776]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:7559775]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043495 protein-membrane adaptor activity [PMID:7559775]" /experiment="EXISTENCE:direct assay:GO:0070762 nuclear pore transmembrane ring [PMID:7559775|PMID:19414609|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:19414609]" /experiment="EXISTENCE:genetic interaction:GO:0017056 structural constituent of nuclear pore [PMID:16682526]" /experiment="EXISTENCE:genetic interaction:GO:0030474 spindle pole body duplication [PMID:20713690]" /experiment="EXISTENCE:physical interaction:GO:0070762 nuclear pore transmembrane ring [PMID:19414609]" /note="Glycoprotein subunit of transmembrane ring of nuclear pore complex; contributes to nucleocytoplasmic transport, nuclear pore complex (NPC) biogenesis and spindle pole body duplication; type II transmembrane protein composed of N-terminal cytosolic and C-terminal nuclear envelope lumenal domains; homologous to human NUP210" /db_xref="GeneID:855159" /db_xref="SGD:S000004736" ORIGIN 1 mehrynvfnd tprgnhwmgs svsgsprpsy ssrpnvnttr rfqysddepa ekirplrsrs 61 fkstesnisd eksriserds kdryingdkk vdiyslplis tdvleiskqr tfavilflii 121 qcykiydlvi lksglplsgl lfknyrfnfi skyfiidsff lyvlpsfnip rltfkpwvvy 181 lqilamllln ifissdhefv lislimttwr klytkelsvt gsainhhrif dssahfkgal 241 tikilpenta mfnplhesyc lpmdtnlfki nsidvpirin steeieyiel eyrdlytnsv 301 elrslskkdf kiidnpksfl kkdqsvlksh sndfeegsti rylavtlqdi gfyqikkivd 361 skklnlkihq shlvvpycpi asitgtgsnd rcigdsdnvs feiqgvppmk layskivngq 421 tfsyvdsslq peyfesplqs skskqsftqg elndlkwgrn qpvninldss itqdgkfayk 481 idkitdglgn vvdftslpee lkkrydlsyn fnvhevpraa leerfdpksp tkrsiaivfe 541 eiknwisdip yvislsytda qdkskkimnv ttdsltkvlq adlpgsynle yieskfcpge 601 ivgksnvlvt mpvaptmevk sfpildqcvg qvglnfelsf tgappyyynt kiyklenger 661 klydakryts egtrnrfsys ppkegnyeiv fdtvsnklft epiklepvke ytfktsmrvk 721 psaslklhhd lklclgdhss vpvalkgqgp ftltydiiet fsskrktfei keiktneyvi 781 ktpvfttggd yilslvsikd stgcvvglsq pdakiqvrrd ipsaafnffe pikeakikhg 841 svteiplkls gegpftvkfk hmdydgnivk efenkfqnsy kpalkvskeg lyqlvdirds 901 scqgnviyrn slykvsflek pkfaiqdnhh itkvtenlfs keevcqgmeg tvdlalfgsp 961 pfileydlma pnghistkki qvatkyaslk lpnqipgeyi ttikaifdgn ygesdihfre 1021 hqseliikqt vhpipdvafa dggktlraca anvdqisfle pinlkflqge spfsitfsvy 1081 hestsrtdqy tidnidsenf sfeklyegmk lgnhaitids vvdangcvns lisgprnqil 1141 vsitdapkih ildpsteycv gdyvayqlng vapfmikyef ngiplksker ssqfvrlase 1201 pgiisitslq dsssqcivdf tnpklksefd dlslnihpip svtvsqgnyv tediregdqa 1261 evifsfegtp pfsltyvrte etdgkhgkrr sqvvethkvt diysheykvi tslqgtyeai 1321 eitdaycfak ndlffnn // LOCUS NP_013849 302 aa linear PLN 30-JUN-2025 DEFINITION Dpi35p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013849 VERSION NP_013849.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182631.1 REFERENCE 1 (residues 1 to 302) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 302) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 302) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 302) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10027. Method: conceptual translation. FEATURES Location/Qualifiers source 1..302 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..302 /product="Dpi35p" /calculated_mol_wt="35147" Region 23..235 /region_name="DREG-2" /note="REG-2-like, HAD superfamily (subfamily IA) hydrolase; TIGR02252" /db_xref="CDD:274056" CDS 1..302 /gene="DPI35" /locus_tag="YMR130W" /coded_by="NM_001182631.1:1..909" /note="Putative mitochondrial hypothetical protein; DPI35 is not an essential gene" /db_xref="GeneID:855160" /db_xref="SGD:S000004737" ORIGIN 1 mtypkripin awsevhrvar pliitfdayn tlyatklpvm eqycivgrky gikanpstlt 61 nnfphvfkkl kedypqygky sgikpeqwws ilirnvfapn eipdeminei lmrfegfdsy 121 fvypdlikfl kdlksrhpdv ilgivsntdp ifykllknig lfetfsghiy lsyelnlakp 181 draifqyald diiskqphll ekytreeilq hcfhigdelk ndlegaeaag wtgilldrnd 241 kygflsnsis kpmrdeykls idkidnnsin tweantkqtd tlqlserkyv vsnlevleel 301 fp // LOCUS NP_013850 511 aa linear PLN 30-JUN-2025 DEFINITION ribosome biosynthesis protein RRB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013850 VERSION NP_013850.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182632.1 REFERENCE 1 (residues 1 to 511) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 511) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 511) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 511) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10028. Method: conceptual translation. FEATURES Location/Qualifiers source 1..511 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..511 /product="ribosome biosynthesis protein RRB1" /calculated_mol_wt="57130" Region 108..175 /region_name="CAF1C_H4-bd" /note="Histone-binding protein RBBP4 or subunit C of CAF1 complex; pfam12265" /db_xref="CDD:463513" Region <230..448 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 276..317 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 325..361 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 369..414 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 420..461 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 482..506 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..511 /gene="RRB1" /locus_tag="YMR131C" /coded_by="NM_001182632.1:1..1536" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:26112308]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:11728313]" /note="Specific assembly chaperone for ribosomal protein Rpl3p; co-translationally associates with nascent Rpl3p, preventing aggregation, and facilitating nuclear import; required for biogenesis of preribosomal particles; essential gene; contains five WD-repeat motifs" /db_xref="GeneID:855161" /db_xref="SGD:S000004738" ORIGIN 1 mskrsievne eqdrvvsakt eshsvpaipa seeqdapknd leeqlsdefd sdgeiieidg 61 ddeindeddl rkkqeeaetl vqkdqsegnk ekiqelylph msrplgpdev leadptvyem 121 lhnvnmpwpc ltldvipdtl gserrnypqs illttatqss rkkenelmvl alsnlaktll 181 kddnegedde eddeddvdpv ieneniplrd ttnrlkvspf aisnqevlta tmsengdvyi 241 ynlapqskaf stpgyqipks akrpihtvkn hgnvegygld wspliktgal lsgdcsgqiy 301 ftqrhtsrwv tdkqpftvsn nksiediqws rtestvfata gcdgyiriwd trskkhkpai 361 svkasntdvn viswsdkigy llasgddngt wgvwdlrqft psnadavqpv aqydfhkgai 421 tsiafnplde sivavgsedn tvtlwdlsve addeeikqqa aetkelqeip pqllfvhwqk 481 evkdvkwhkq ipgclvstgt dglnvwktis v // LOCUS NP_013851 208 aa linear PLN 30-JUN-2025 DEFINITION Jlp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013851 VERSION NP_013851.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182633.1 REFERENCE 1 (residues 1 to 208) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 208) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 208) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 208) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10029. Method: conceptual translation. FEATURES Location/Qualifiers source 1..208 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..208 /product="Jlp2p" /calculated_mol_wt="24534" Region 1..117 /region_name="NFACT-R_1" /note="NFACT protein RNA binding domain; pfam05670" /db_xref="CDD:428576" CDS 1..208 /gene="JLP2" /locus_tag="YMR132C" /coded_by="NM_001182633.1:1..627" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)" /db_xref="GeneID:855162" /db_xref="SGD:S000004739" ORIGIN 1 mvyfyeskpt eystpyqivm gkdkfendll ikwsyrelny vwfhadkyss ghvylklrpn 61 ektiddipqe vicdclqlck sesiqgnkmp qctilitpwh nlrknrymnp gevsfkslrq 121 crkmecgard nkilnrlakt rvelfnnvea tlneakktkn gdffvnyies nrsnlieeek 181 lrkvakknqk kknkqskdev tddmqlev // LOCUS NP_013852 428 aa linear PLN 30-JUN-2025 DEFINITION Rec114p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013852 VERSION NP_013852.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182634.1 REFERENCE 1 (residues 1 to 428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 428) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10030. Method: conceptual translation. FEATURES Location/Qualifiers source 1..428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..428 /product="Rec114p" /calculated_mol_wt="48575" Region 6..138 /region_name="Meiotic_rec114" /note="Meiotic recombination protein Rec7 N-terminal domain; pfam03525" /db_xref="CDD:460957" CDS 1..428 /gene="REC114" /locus_tag="YMR133W" /coded_by="NM_001182634.1:1..1287" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:17558514|PMID:16783010]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:8417989]" /note="Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division" /db_xref="GeneID:855163" /db_xref="SGD:S000004740" ORIGIN 1 myeycsvvik kyskytipsf apngfqsmle ppqidkwqhl sanctlqfrv llmdsrqili 61 nvvlnnstll enirlplgdn qdliqfscks piisckyise efgprmlrrf qmnlpndvef 121 nrtvvslknl nfvlrtarts iaqstitsqv qgnnngtkvc ftegpkvssy tnpntqfqtq 181 nmimdfsqry qeeseresnn rsnitlphds iqiaqqiwpn tdlnvvqssq dlntpmatqt 241 vlgrpesliv qplevsqspp nttnclpnae nkkkkvdtts dftsrkeial cktglletih 301 ipkeresqmq svtgldatpt iiwspgkdnt akkntsnkkn iddkltnpqk sgnthtpdrn 361 kevlpngtln etrkeaspse gltirvknvn rnasrkiskr likeklkdee fmkwvnkvet 421 vlnkmfek // LOCUS NP_013853 237 aa linear PLN 30-JUN-2025 DEFINITION Erg29p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013853 VERSION NP_013853.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182635.1 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10031. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..237 /product="Erg29p" /calculated_mol_wt="27790" CDS 1..237 /gene="ERG29" /locus_tag="YMR134W" /coded_by="NM_001182635.1:1..714" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14690591|PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:12880870]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:29773647|PMID:8552601|PMID:23892078]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9180083]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:16135527]" /note="hypothetical protein involved in ergosterol biosynthesis; conditional mutants produce less ergosterol, display impaired oxygen consumption, respiratory growth, mitochondrial iron utilization, and are more sensitive to oxidative stress; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; protein localizes to the cytoplasm, ER and nuclear envelope; highly conserved in ascomycetes" /db_xref="GeneID:855164" /db_xref="SGD:S000004741" ORIGIN 1 mslkdrylnl elklinklqe lpyvhqfihd risgritlfl ivvgtlaffn elyitiemsl 61 lqkntseele rgrideslkl hrmlvsdeyh gkeykdeksg ivieefedrd kffakpvfvs 121 eldvecnviv dgkellstpl kfhvefsped yenekrpefg ttlrvlrlrl yhyfkdceiy 181 rdiiknegge garkftisng vkiynhkdel lplniddvql cflkidtgnt ikcefil // LOCUS NP_013854 455 aa linear PLN 30-JUN-2025 DEFINITION glucose-induced degradation complex subunit GID8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013854 VERSION NP_013854.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182636.1 REFERENCE 1 (residues 1 to 455) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 455) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 455) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 455) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10032. Method: conceptual translation. FEATURES Location/Qualifiers source 1..455 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..455 /product="glucose-induced degradation complex subunit GID8" /calculated_mol_wt="51598" Region 130..296 /region_name="CTLH" /note="CTLH/CRA C-terminal to LisH motif domain; pfam10607" /db_xref="CDD:402305" CDS 1..455 /gene="GID8" /locus_tag="YMR135C" /gene_synonym="DCR1" /coded_by="NM_001182636.1:1..1368" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0034657 GID complex [PMID:16872538|PMID:18508925]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:15590836]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:12686616]" /experiment="EXISTENCE:mutant phenotype:GO:0045721 negative regulation of gluconeogenesis [PMID:12686616]" /note="Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START" /db_xref="GeneID:855166" /db_xref="SGD:S000004742" ORIGIN 1 mtistlsnet tksgscsgqg knggkdftyg kkcftkeewk eqvakysamg elyanktihy 61 plkiqpnssg gsqdegfati qttpieptlp rlllnyfvsm ayedssirma kelgfirnnk 121 diavfndlyk ikerfhikhl iklgrineam eeinsifgle vleetfnatg sytgrtdrqq 181 qqqqqqfdid gdlhfkllll nliemirshh qqenitkdsn dfilnliqys qnklaikass 241 svkkmqelel amtlllfpls dsadsgsikl pkslqnlysi slrskiadlv nekllkfihp 301 riqfeisnnn skfpdllnsd kkiitqnftv ynnnlvngsn gtkithissd qpinekmssn 361 evtaaansvw lnqrdgnvgt gsaattfhnl enknywnqts ellsssngke kglefnnyys 421 sefpyeprlt qimklwcwce nqlhhnqigv prven // LOCUS NP_013856 560 aa linear PLN 30-JUN-2025 DEFINITION Gat2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013856 VERSION NP_013856.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182638.1 REFERENCE 1 (residues 1 to 560) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 560) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 560) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 560) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10033. Method: conceptual translation. FEATURES Location/Qualifiers source 1..560 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..560 /product="Gat2p" /calculated_mol_wt="63008" Region 25..551 /region_name="GAT1" /note="GATA Zn-finger-containing transcription factor [Transcription]; COG5641" /db_xref="CDD:227928" CDS 1..560 /gene="GAT2" /locus_tag="YMR136W" /coded_by="NM_001182638.1:1..1683" /note="Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine" /db_xref="GeneID:855167" /db_xref="SGD:S000004744" ORIGIN 1 mqapniypfs qtqpqalpgf tygppqlvfd hsaprvdplh stvtinsplp lqhyngpnah 61 insannnyay yyhhpnnndn nnhsnntikn nninsvlpav niqisnnshy rnthqipsap 121 qrlvsiipdp hmppnishfq lnnihpqmha pvatdihfqq vpvynktnng igtdninndk 181 pvnsnqnevl dnidersche inrvvsfskh fennelttta ndlniqstmd elaklkslsn 241 sthfrqsiat qnfhslqnhi ttienrlasl ltdrqqeqqq lkqqesekes sspfsnkikl 301 pslqeltdsi stqhlptfyd nkrhasdtdl ksstlhgply hrhaflstss sspsptagsa 361 plqklqvprq ddpndkkmni ssspfnsity ipnttlspmv qtqlknltts nlntkkknnr 421 grpraiqrqp tlttsshfin nsnpgaaavs tttpaansde knpnakkiie fcfhcgetet 481 pewrkgpygt rtlcnacglf yrkvtkkfgs kssnlllryr rsidlandrr ipdfitipnr 541 fihdmdndqt ldseyntilq // LOCUS NP_013857 661 aa linear PLN 30-JUN-2025 DEFINITION DNA cross-link repair protein PSO2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013857 VERSION NP_013857.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182639.1 REFERENCE 1 (residues 1 to 661) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 661) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 661) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 661) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10034. Method: conceptual translation. FEATURES Location/Qualifiers source 1..661 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..661 /product="DNA cross-link repair protein PSO2" /calculated_mol_wt="76268" Region 202..380 /region_name="SNM1A-1C-like_MBL-fold" /note="SNM1A, artemis/SNM1C, yeast Pso2p, and related proteins; MBL-fold metallo-hydrolase domain; cd16273" /db_xref="CDD:293831" Site order(248,250,252..253,318..319,347,376) /site_type="active" /note="putative active site [active]" /db_xref="CDD:293831" Region 488..637 /region_name="DRMBL" /note="DNA repair metallo-beta-lactamase; pfam07522" /db_xref="CDD:429512" CDS 1..661 /gene="PSO2" /locus_tag="YMR137C" /gene_synonym="SNM1" /coded_by="NM_001182639.1:1..1986" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:35482533]" /experiment="EXISTENCE:direct assay:GO:0008409 5'-3' exonuclease activity [PMID:35482533|PMID:15590324]" /experiment="EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]" /experiment="EXISTENCE:mutant phenotype:GO:0003684 damaged DNA binding [PMID:7035927]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:35482533|PMID:1736091]" /experiment="EXISTENCE:mutant phenotype:GO:0008409 5'-3' exonuclease activity [PMID:15590324]" /experiment="EXISTENCE:mutant phenotype:GO:0036297 interstrand cross-link repair [PMID:22912599]" /note="Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress; translocates to mitochondria under genotoxic agents" /db_xref="GeneID:855168" /db_xref="SGD:S000004745" ORIGIN 1 msrksivqir rsevkrkrss tasstsegkt lhknthtssk rqrtltefni ptssnlpvrs 61 ssysfsrfsc stsnkntepv iindddhnsi cledtakvei tidtdeeelv slhdnevsai 121 enrtedrivt eleeqvnvkv steviqcpic lenlshlely erethcdtci gsdpsnmgtp 181 kknirsfisn psspaktkrd iatskkptrv klvlpsfkii kfnngheivv dgfnykaset 241 isqyflshfh sdhyiglkks wnnpdenpik ktlycskita ilvnlkfkip mdeiqilpmn 301 krfwitdtis vvtldanhcp gaiimlfqef lansydkpir qilhtgdfrs nakmietiqk 361 wlaetaneti dqvyldttym tmgynfpsqh svcetvadft lrlikhgknk tfgdsqrnlf 421 hfqrkktltt hryrvlflvg tytigkekla ikiceflktk lfvmpnsvkf smmltvlqnn 481 enqndmwdes lltsnlhess vhlvpirvlk sqetieaylk slkeletdyv kdiedvvgfi 541 ptgwshnfgl kyqkknddde nemsgnteyc lelmkndrdn ddengfeiss ilrqykkynk 601 fqvfnvpyse hssfndlvkf gcklkcsevi ptvnlnnlwk vrymtnwfqc wenvrktraa 661 k // LOCUS NP_013858 191 aa linear PLN 30-JUN-2025 DEFINITION Arf family GTPase CIN4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013858 VERSION NP_013858.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182640.1 REFERENCE 1 (residues 1 to 191) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 191) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 191) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 191) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10035. Method: conceptual translation. FEATURES Location/Qualifiers source 1..191 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..191 /product="Arf family GTPase CIN4" /calculated_mol_wt="21936" Region 17..187 /region_name="Arf" /note="ADP-ribosylation factor family; pfam00025" /db_xref="CDD:459636" CDS 1..191 /gene="CIN4" /locus_tag="YMR138W" /gene_synonym="GTP1; UGX1" /coded_by="NM_001182640.1:1..576" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:2407611]" /experiment="EXISTENCE:genetic interaction:GO:0007021 tubulin complex assembly [PMID:9215891]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9215891]" /note="GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog" /db_xref="GeneID:855169" /db_xref="SGD:S000004746" ORIGIN 1 mgllsiirkq klrdkeircl ilgldnsgks tivnkllpkd eqnndgimpt vgfqihslmi 61 kdvtislwdi ggqrtlrpfw dnyfdktqam iwcidvslsm rfdetlqelk elinrdenri 121 gyecavivvl nkidlvedks elhrrcllve selkclfkpd irielvkcsg vtgegidnlr 181 drlveschft q // LOCUS NP_013859 370 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase RIM11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013859 VERSION NP_013859.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182641.1 REFERENCE 1 (residues 1 to 370) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 370) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 370) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 370) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10036. Method: conceptual translation. FEATURES Location/Qualifiers source 1..370 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..370 /product="serine/threonine protein kinase RIM11" /EC_number="2.7.11.1" /calculated_mol_wt="42874" Region 34..325 /region_name="STKc_GSK3" /note="The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; cd14137" /db_xref="CDD:271039" Site order(45..49,53,66,68,79,93,114..117,120,122..123,164,166, 168..169,171,183,186,197,199..202,204,242) /site_type="active" /db_xref="CDD:271039" Site order(45..48,53,66,68,93,114..117,120,166,168..169,171,183) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271039" Site order(49..50,195..203,211..212,243..247,249..250,254, 274..277) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:271039" Site order(79,122,164,166,186,197,199..202,204,242) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271039" Site order(182..192,194..204) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271039" Site order(211,246..247,249..250,253..254,274..279) /site_type="other" /note="axin binding site [polypeptide binding]" /db_xref="CDD:271039" CDS 1..370 /gene="RIM11" /locus_tag="YMR139W" /gene_synonym="GSK3; MDS1" /coded_by="NM_001182641.1:1..1113" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:9372955|PMID:7969131]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:10679022]" /note="Ser/Thr protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication" /db_xref="GeneID:855170" /db_xref="SGD:S000004747" ORIGIN 1 mniqsnnspn lsnnivskqv yyahppptid pndpvqisfp ttevvghgsf gvvfatviqe 61 tnekvaikkv lqdkrfknre leimkmlshi niidlkyffy erdsqdeiyl nlileympqs 121 lyqrlrhfvh qrtpmsrlei kyymfqlfks lnylhhfanv chrdikpqnl lvdpetwslk 181 lcdfgsakql kptepnvsyi csryyrapel ifgatnytnq idiwssgcvm aelllgqpmf 241 pgesgidqlv eiikilgtps kqeicsmnpn ymehkfpqik piplsrvfkk eddqtvefla 301 dvlkydpler fnalqclcsp yfdelklddg kinqittdlk llefdenvel ghlspdelss 361 vkkklypksk // LOCUS NP_013860 489 aa linear PLN 30-JUN-2025 DEFINITION Sip5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013860 VERSION NP_013860.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182642.1 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10037. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..489 /product="Sip5p" /calculated_mol_wt="55728" Region 96..417 /region_name="SIP5-like" /note="SNF1-interacting protein 5 and similar proteins; cd24139" /db_xref="CDD:467940" CDS 1..489 /gene="SIP5" /locus_tag="YMR140W" /coded_by="NM_001182642.1:1..1470" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:10628972]" /note="hypothetical protein; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:855171" /db_xref="SGD:S000004748" ORIGIN 1 mgnvpgkidq edsfndvrpd ssynttssns vikqydeeas srvrtrrtts lvnnilngnn 61 artktgshls stsrrktsre kelakeahak qlvvrcsetv dggflapfgc ysfekldyda 121 tvvknliikr klapfytplq dfdeswtrde likivdglpl hdtfdenlee fedvpignlr 181 kstfnelidk slskkeqrrm hakifrarly kkrilwqene netflerkle mkrigskssn 241 vedntssqpr knyhlpsddl kytlykngse cpicflyfpg pfnyskccqq pictecfvqi 301 kradphfphd evdptepqtn dsekdpnllt sepancpyca tasfsityqp ptnretgigg 361 mpadsyvykd aaisradggq pnisaitsdt irpdweikln kerarlmrrs anataihisn 421 rlidpshsrr rntshsitpi hdestsasrs peptineled qmvreairls ledqdnrkks 481 knrntslrp // LOCUS NP_001335808 102 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR141C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335808 VERSION NP_001335808.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348868.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80328. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..102 /product="uncharacterized protein" /calculated_mol_wt="11977" CDS 1..102 /locus_tag="YMR141C" /coded_by="NM_001348868.1:1..309" /note="hypothetical protein; conserved among S. cerevisiae strains; YMR141C is not an essential gene" /db_xref="GeneID:855172" /db_xref="SGD:S000004749" ORIGIN 1 msrtdtsekr kedfiyvsln iylcvrlyim hlissntpks hcsvrflcff lsalaitsnr 61 nffrpekmpt rifcndtlmv spktekfler ftnqklakle vr // LOCUS NP_013862 199 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL13 RPL13B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013862 VERSION NP_013862.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182644.1 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10038. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..199 /product="60S ribosomal protein eL13 RPL13B" /calculated_mol_wt="22394" Region 8..175 /region_name="Ribosomal_L13e" /note="Ribosomal protein L13e; pfam01294" /db_xref="CDD:460150" CDS 1..199 /gene="RPL13B" /locus_tag="YMR142C" /coded_by="NM_001182644.1:1..600" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /note="Ribosomal 60S subunit protein L13B; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13B has a paralog, RPL13A, that arose from the whole genome duplication" /db_xref="GeneID:855173" /db_xref="SGD:S000004750" ORIGIN 1 maisknlpil knhfrkhwqe rvkvhfdqag kkvsrrnara araakiaprp ldllrpvvra 61 ptvkynrkvr agrgftlaev kaagltaaya rtigiavdhr rqnrnqeifd anvqrlkeyq 121 skiivfprdg kapeaeqvls aaatfpiaqp atdvearavq dngesafrtl rlarsekkfr 181 girekrarek aeaeaekkk // LOCUS NP_013863 143 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS9 RPS16A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013863 VERSION NP_013863.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182645.1 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10039. On Aug 9, 2000 this sequence version replaced NP_013863.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..143 /product="40S ribosomal protein uS9 RPS16A" /calculated_mol_wt="15716" Region 3..143 /region_name="PLN00210" /note="40S ribosomal protein S16; Provisional" /db_xref="CDD:177799" CDS 1..143 /gene="RPS16A" /locus_tag="YMR143W" /coded_by="NM_001182645.1:1..432" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:genetic interaction:GO:0006413 translational initiation [PMID:30481328]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16A has a paralog, RPS16B, that arose from the whole genome duplication" /db_xref="GeneID:855174" /db_xref="SGD:S000004751" ORIGIN 1 msavpsvqtf gkkksatava hvkagkglik vngspitlve peilrfkvye plllvgldkf 61 snidirvrvt ggghvsqvya irqaiakglv ayhqkyvdeq sknelkkaft sydrtlliad 121 srrpepkkfg gkgarsrfqk syr // LOCUS NP_013864 342 aa linear PLN 30-JUN-2025 DEFINITION Fdo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013864 VERSION NP_013864.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182646.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10040. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..342 /product="Fdo1p" /calculated_mol_wt="38439" CDS 1..342 /gene="FDO1" /locus_tag="YMR144W" /coded_by="NM_001182646.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0007535 donor selection [PMID:27257873]" /experiment="EXISTENCE:physical interaction:GO:0007535 donor selection [PMID:27257873]" /note="Protein involved in directionality of mating type switching; acts with Fkh1p to control which donor mating-type locus is inserted into MAT locus during mating type switching; localized to the nucleus; not an essential gene" /db_xref="GeneID:855175" /db_xref="SGD:S000004752" ORIGIN 1 meenklsgnk piqlatwsnq mgspenngnn anngsdvqnv iqkalglirq lnnnglmspm 61 eeehsqpsss qetlsvdrei neqgrlrllm qakddntrke vgtysspmds ayarenmlnv 121 lqslvthlnq avsqiqqlkf knmiltsnen niqsrheved nlqkqqferm kcqfllerqs 181 lkdqlrkren kivkykqkii eknkklnnla kvlnqhaisd tsqidsfsss vkktpssttt 241 pqemksdmln tlgilathvl kdeidddsgn qtilqlaags isndcnttel eitcspemgr 301 tithnrpntk desiqdshgn rtlqlpkmks fstidgsikd ik // LOCUS NP_013865 560 aa linear PLN 30-JUN-2025 DEFINITION NADH-ubiquinone reductase (H(+)-translocating) NDE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013865 VERSION NP_013865.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182647.1 REFERENCE 1 (residues 1 to 560) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 560) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 560) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 560) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10041. Method: conceptual translation. FEATURES Location/Qualifiers source 1..560 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..560 /product="NADH-ubiquinone reductase (H(+)-translocating) NDE1" /EC_number="1.6.5.9" /calculated_mol_wt="62643" Region 111..559 /region_name="PTZ00318" /note="NADH dehydrogenase-like protein; Provisional" /db_xref="CDD:185553" CDS 1..560 /gene="NDE1" /locus_tag="YMR145C" /gene_synonym="NDH1" /coded_by="NM_001182647.1:1..1683" /experiment="EXISTENCE:direct assay:GO:0003954 NADH dehydrogenase activity [PMID:9733747|PMID:9696750]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9733747|PMID:9696750|PMID:16823961|PMID:14576278|PMI D:24769239]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:31668496]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9696750|PMID:9733747]" /experiment="EXISTENCE:mutant phenotype:GO:0019655 glycolytic fermentation to ethanol [PMID:9733747|PMID:9696750]" /experiment="EXISTENCE:mutant phenotype:GO:0042981 regulation of apoptotic process [PMID:31668496]" /note="Mitochondrial external NADH dehydrogenase; type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain; NDE1 has a paralog, NDE2, that arose from the whole genome duplication" /db_xref="GeneID:855176" /db_xref="SGD:S000004753" ORIGIN 1 mirqslmktv wanssrfslq sksglvkyak nrsfhaarnl ledkkvilqk vapttgvvak 61 qsffkrtgkf tlkallysal agtayvsysl yreanpstqv pqsdtfpngs krktlvilgs 121 gwgsvsllkn ldttlynvvv vsprnyflft pllpstpvgt ielksivepv rtiarrshge 181 vhyyeaeayd vdpenktikv kssaknndyd ldlkydylvv gvgaqpntfg tpgvyeyssf 241 lkeisdaqei rlkimssiek aaslspkdpe rarllsfvvv gggptgvefa aelrdyvdqd 301 lrkwmpelsk eikvtlveal pnilnmfdky lvdyaqdlfk eekidlrlkt mvkkvdatti 361 taktgdgdie nipygvlvwa tgnaprevsk nlmtkleeqd srrgllidnk lqllgakgsi 421 faigdctfhp glfptaqvah qegeylaqyf kkaykidqln wkmthakdds evarlknqiv 481 ktqsqiedfk ynhkgalayi gsdkaiadla vgeakyrlag sftflfwksa ylamclsfrn 541 rvlvamdwak vyflgrdssi // LOCUS NP_013866 347 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF3 subunit i [Saccharomyces cerevisiae S288C]. ACCESSION NP_013866 VERSION NP_013866.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182648.1 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10042. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..347 /product="translation initiation factor eIF3 subunit i" /calculated_mol_wt="38624" Region <6..319 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 13..49 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 56..91 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 96..148 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 156..193 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 240..290 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 297..319 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..347 /gene="TIF34" /locus_tag="YMR146C" /coded_by="NM_001182648.1:1..1044" /experiment="EXISTENCE:direct assay:GO:0002183 cytoplasmic translational initiation [PMID:7798228]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9660829|PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:15838098|PMID:11018020]" /experiment="EXISTENCE:mutant phenotype:GO:0002188 translation reinitiation [PMID:20679478]" /experiment="EXISTENCE:physical interaction:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9660829]" /note="eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; stimulates rate of ribosomal scanning during translation reinitiation; eIF3 is also involved in programmed stop codon readthrough" /db_xref="GeneID:855177" /db_xref="SGD:S000004754" ORIGIN 1 mkaikltghe rpltqvkynk egdllfscsk dssasvwysl ngerlgtldg htgtiwsidv 61 dcftkycvtg sadysiklwd vsngqcvatw kspvpvkrve fspcgnyfla ildnvmknpg 121 siniyeierd satheltkvs eepihkiith egldaatvag wstkgkyiia ghkdgkisky 181 dvsnnyeyvd sidlheksis dmqfspdlty fitssrdtns flvdvstlqv lkkyetdcpl 241 ntavitplke fiilgggqea kdvtttsane gkfearfyhk ifeeeigrvq ghfgplntva 301 ispqgtsyas ggedgfirlh hfeksyfdfk ydvekaaeak ehmqean // LOCUS NP_013867 412 aa linear PLN 30-JUN-2025 DEFINITION Ldo45p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013867 VERSION NP_013867.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182649.2 REFERENCE 1 (residues 1 to 412) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 412) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 412) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 412) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10043. On May 27, 2021 this sequence version replaced NP_013867.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..412 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..412 /product="Ldo45p" /calculated_mol_wt="46546" Region 270..338 /region_name="Osw5" /note="Outer spore wall 5; pfam17062" /db_xref="CDD:407230" CDS 1..412 /gene="LDO45" /locus_tag="YMR147W" /coded_by="NM_001182649.2:1..1239" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:29187528]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:29187528]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:29187528]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the cell periphery" /db_xref="GeneID:855178" /db_xref="SGD:S000004755" ORIGIN 1 maarnrrknn kkksllvtsa aqeknatyvl vaeelhkkti dlnmgtetpl tenhenpipa 61 kefkhqqkle pidehddged elsikfksmt kssgpiteae vqklllsyaf tsaaiqeden 121 ekesrhypik ppspsassls ayfqsfvekc kqvfynfslq tveklnalqn slyevfwiif 181 iylnywfpnv gdyvsntfgq qdsiiirisl skshfralre kssqkvqqav kniyfcfqek 241 pyltafkvsf aiglvipcsl lflimvstat ffffvyltlf vvigffsslf iipllgisfv 301 faigvvsfgf csnmsfkmaq liyvradafl kkvldkmalq tqpaqlqepq eplstlrpvs 361 nptipsplrq tarpskfvte edvifepvsa qsaiarslet tankagnkfq ls // LOCUS NP_013868 148 aa linear PLN 30-JUN-2025 DEFINITION Ldo16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013868 VERSION NP_013868.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182650.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10044. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..148 /product="Ldo16p" /calculated_mol_wt="16253" Region 6..74 /region_name="Osw5" /note="Outer spore wall 5; pfam17062" /db_xref="CDD:407230" CDS 1..148 /gene="LDO16" /locus_tag="YMR148W" /gene_synonym="OSW5" /coded_by="NM_001182650.1:1..447" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:29187528]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:29187528]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:19779569]" /experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:29187528]" /note="hypothetical protein with possible role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion" /db_xref="GeneID:855179" /db_xref="SGD:S000004756" ORIGIN 1 mvstatffff vyltlfvvig ffsslfiipl lgisfvfaig vvsfgfcsnm sfkmaqliyv 61 radaflkkvl dkmalqtqpa qlqepqepls tlrpvsnpti psplrqtarp skfvteedvi 121 fepvsaqsai arslettank agnkfqls // LOCUS NP_013869 286 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-diphosphooligosaccharide-protein glycotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013869 VERSION NP_013869.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182651.1 REFERENCE 1 (residues 1 to 286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 286) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10045. Method: conceptual translation. FEATURES Location/Qualifiers source 1..286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..286 /product="dolichyl-diphosphooligosaccharide-protein glycotransferase" /calculated_mol_wt="31522" Region <156..282 /region_name="Ribophorin_II" /note="Oligosaccharyltransferase subunit Ribophorin II; pfam05817" /db_xref="CDD:461749" CDS 1..286 /gene="SWP1" /locus_tag="YMR149W" /coded_by="NM_001182651.1:1..861" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:29466327]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:29466327]" /experiment="EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:29466327]" /experiment="EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]" /experiment="EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]" /experiment="EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]" /note="Delta subunit of the oligosaccharyl transferase glycoprotein complex; complex is required for N-linked glycosylation of proteins in the endoplasmic reticulum" /db_xref="GeneID:855180" /db_xref="SGD:S000004757" ORIGIN 1 mqffktlaal vscisfvlay vaqdvhvsfp stagksrvmi gkveprigid etvpttitve 61 dpneviqvnf aiestnkpfq ntlliglpnk nlemafepei kdngklsmyk yridlaklda 121 allqeasrsp epikatlila sstakpkenl freilqlnln fdvdhsdssl vdkfgikpei 181 hhifhaepkr vakpiavifv liifitilsl ivtwlnscaa afnniptgvt avyflgfiat 241 ivgfevifar yylgtsifet lfsslylgap glltstkflr sfgqti // LOCUS NP_013870 190 aa linear PLN 30-JUN-2025 DEFINITION endopeptidase catalytic subunit IMP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013870 VERSION NP_013870.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182652.1 REFERENCE 1 (residues 1 to 190) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 190) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 190) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 190) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10046. Method: conceptual translation. FEATURES Location/Qualifiers source 1..190 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..190 /product="endopeptidase catalytic subunit IMP1" /calculated_mol_wt="21302" Region 38..155 /region_name="sigpep_I_bact" /note="signal peptidase I, bacterial type; TIGR02227" /db_xref="CDD:274044" CDS 1..190 /gene="IMP1" /locus_tag="YMR150C" /coded_by="NM_001182652.1:1..573" /experiment="EXISTENCE:direct assay:GO:0004175 endopeptidase activity [PMID:1991446|PMID:8132591]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006627 protein processing involved in protein targeting to mitochondrion [PMID:1991446]" /experiment="EXISTENCE:physical interaction:GO:0042720 mitochondrial inner membrane peptidase complex [PMID:8266095]" /note="Catalytic subunit of mitochondrial inner membrane peptidase complex; required for maturation of mitochondrial proteins of the intermembrane space; complex contains two catalytic subunits (Imp1p and Imp2p that differ in substrate specificty) and Som1p" /db_xref="GeneID:855182" /db_xref="SGD:S000004758" ORIGIN 1 mtvgtlpiws ktfsyairsl cflhiihmya yeftetrges mlptlsatnd yvhvlknfqn 61 grgikmgdci valkptdpnh rickrvtgmp gdlvlvdpst ivnyvgdvlv deerfgtyik 121 vpeghvwvtg dnlshsldsr tynalpmgli mgkivaannf dkpfwdgsir niwgfkwinn 181 tfldvqaksn // LOCUS NP_013872 365 aa linear PLN 30-JUN-2025 DEFINITION Yim1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013872 VERSION NP_013872.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182654.1 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10047. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..365 /product="Yim1p" /calculated_mol_wt="41506" Region 8..364 /region_name="AST1_like" /note="AST1 is a cytoplasmic protein associated with the periplasmic membrane in yeast; cd08247" /db_xref="CDD:176209" Site order(48..50,53,148,152,174..177,179..180,199..200,209,221, 247..248,250,273..274,310..312) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:176209" CDS 1..365 /gene="YIM1" /locus_tag="YMR152W" /coded_by="NM_001182654.1:1..1098" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:10515935|PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0018455 alcohol dehydrogenase [NAD(P)+] activity [PMID:32967812]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:12077312]" /note="Aldehyde reductase; involved in detoxification of lignocellulose-derived aldehydes; catalyzes the reduction of furan, aliphatic and aromatic aldehydes using either NADH or NADPH as co-factor; membrane of the quinone oxidoreductase subfamily of the medium-chain dehydrogenase/reductase family; null mutant displays sensitivity to DNA damaging agents; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855183" /db_xref="SGD:S000004760" ORIGIN 1 msdeivtnks vtyvnnttpv titsseldlr scyqddevvi evhaaalnpi dfithqlcns 61 yifgkypkty srdysgviik agkdvdnrwk vgdkvngmys hiygergtlt hylilnpakd 121 vpithmvevp kdendpyddf vyaaawpltf gtafstlydf kkdwtsdskv lvigastsvs 181 yafvhiakny fnigtvvgic sknsiernkk lgydylvpyd egsivenvkk lkqsvlendk 241 fdmifdsvgn hdffpvidqf lkpkaknsfy vtiagnnkad ykniswrdfv slssilkain 301 pfkkynwrfg hpyppnnfie vgnemikkgt ykppidsvye fdqykeaidr lmsnrakgkv 361 vvkmk // LOCUS NP_013873 475 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin NUP53 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013873 VERSION NP_013873.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182656.1 REFERENCE 1 (residues 1 to 475) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 475) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 475) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 475) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10048. Method: conceptual translation. FEATURES Location/Qualifiers source 1..475 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..475 /product="FG-nucleoporin NUP53" /calculated_mol_wt="52488" Region 250..347 /region_name="RRM_Nup53p_fungi" /note="RNA recognition motif (RRM) found in yeast nucleoporin Nup53p and similar proteins; cd12721" /db_xref="CDD:410120" CDS 1..475 /gene="NUP53" /locus_tag="YMR153W" /coded_by="NM_001182656.1:1..1428" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:17897934]" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:17897934]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:9864357|PMID:11071914]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:11071914]" /experiment="EXISTENCE:direct assay:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:genetic interaction:GO:0006606 protein import into nucleus [PMID:9864357]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:11071914]" /experiment="EXISTENCE:genetic interaction:GO:0006999 nuclear pore organization [PMID:19414609]" /experiment="EXISTENCE:genetic interaction:GO:0045893 positive regulation of DNA-templated transcription [PMID:15817685]" /experiment="EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:11071914]" /experiment="EXISTENCE:mutant phenotype:GO:0007088 regulation of mitotic nuclear division [PMID:14697200]" /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:12473689]" /experiment="EXISTENCE:mutant phenotype:GO:0060188 regulation of protein desumoylation [PMID:17403926]" /experiment="EXISTENCE:mutant phenotype:GO:0072417 response to spindle checkpoint signaling [PMID:12473689]" /experiment="EXISTENCE:physical interaction:GO:0007088 regulation of mitotic nuclear division [PMID:14697200]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:9864357|PMID:17418788]" /experiment="EXISTENCE:physical interaction:GO:0060188 regulation of protein desumoylation [PMID:17403926]" /note="FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication" /db_xref="GeneID:855184" /db_xref="SGD:S000004762" ORIGIN 1 madlqkqens srftnvsvia pesqgqheqq kqqeqleqqk qptgllkgln gfpsapqplf 61 medppstvsg elndnpawfn nprkraipns iikrsngqsl spvrsdsadv pafsnsngfn 121 nvtfgskkdp rilknvspnd nnsannnahs sdlgtvvfds neappktsla dwqkedgifs 181 sktdniedpn lssnitfdgk ptatpspfrp lektsrilnf fdkntkttpn tasseasags 241 kegastnwdd haiiifgype tiansiilhf anfgeiledf rvikdfkkln sknmskspsl 301 taqkypiytg dgwvkltyks elsksralqe ngiimngtli gcvsyspaal kqlaslkkse 361 eiinnktssq tslsskdlsn yrktegifek akakavtskv rnaefkvskn stsfknprrl 421 eikdgrslfl rnrgkihsgv lssiesdlkk reqaskskks wlnrlnnwlf gwndl // LOCUS NP_013875 727 aa linear PLN 30-JUN-2025 DEFINITION Rim13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013875 VERSION NP_013875.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182657.1 REFERENCE 1 (residues 1 to 727) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 727) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 727) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 727) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 727) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 727) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 727) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10049. Method: conceptual translation. FEATURES Location/Qualifiers source 1..727 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..727 /product="Rim13p" /calculated_mol_wt="82993" CDS 1..727 /gene="RIM13" /locus_tag="YMR154C" /gene_synonym="CPL1" /coded_by="NM_001182657.1:1..2184" /experiment="EXISTENCE:direct assay:GO:0004197 cysteine-type endopeptidase activity [PMID:9928935]" /experiment="EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:9928935]" /note="Calpain-like cysteine protease; involved in proteolytic activation of Rim101p in response to alkaline pH; localizes to punctate structures in alkaline conditions and in vps4 mutant; has similarity to A. nidulans palB" /db_xref="GeneID:855186" /db_xref="SGD:S000004763" ORIGIN 1 mndwhefnaa iksiycnaeg dsssiinrlv glamksedst fieavlvlke nvskvdkqlr 61 flwltstins rfyppipise aspvswnkte ycapgteelq rrypgraklq needysggie 121 qcrdvpdcsl vaslinlrsk nlnlplikqi sstkyhvnls fngsnkrlvt vdisqiptsv 181 dgkqlslksn disdkigela lllvskgtys tdgsnisidt yrlsgflpei tqvnsypfek 241 lwkfhksnlc lmgagtgnrs ndmikplven hdysiidity dsrlvklrdp rnsalnveis 301 yeqylknfkq lylnwnqekl fkrsqvlhfr ydtsrynkfs ivadkplfhl vnnskvtetv 361 wllleshlqd egsqenrsvs flneapecii cpieppvecg gnhiglqlvk lrldaeterl 421 lycysttnnn fsihsfsvvk eicfqrlkdt kslfakvlfs fpyeiegkas fdtcnffqnp 481 tfelevhseq dyqvlmdaac istsshdlin iqvyyfndye likpimfdnh yqpgqglkqd 541 vpiltnvkym ivcstygppa stefellasi rlssswrlis gitlrsvnli ygtypyhcrn 601 rfhwketsdk lkiqmtlptk kystnklfir vvpvessarl rmrcnifepe salcvyecqe 661 yrtcpsggiv ipdlevsrtn ivvlmiersv pissclpteg qldelelfvg ssqkirieky 721 sddvipk // LOCUS NP_013876 547 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR155W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013876 VERSION NP_013876.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182658.1 REFERENCE 1 (residues 1 to 547) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 547) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 547) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 547) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 547) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10050. Method: conceptual translation. FEATURES Location/Qualifiers source 1..547 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..547 /product="uncharacterized protein" /calculated_mol_wt="59913" Region 17..526 /region_name="MFS" /note="Major Facilitator Superfamily; cl28910" /db_xref="CDD:475125" Site order(28..29,32..33,36,71,125..126,128..130,133,152, 155..156,159,326,329..330,333..335,338,375,379,446..447, 451,455,471,474..475,478..479,482) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:349949" CDS 1..547 /locus_tag="YMR155W" /coded_by="NM_001182658.1:1..1644" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; identified as interacting with Hsp82p in a high-throughput two-hybrid screen" /db_xref="GeneID:855187" /db_xref="SGD:S000004764" ORIGIN 1 mvkkhqnskm gntnhfghlk sfvggnvval gagtpylfsf yapqllskch ipvsasskls 61 fsltigsslm gilagivvdr spklscligs mcvfiaylil nlcykhewss tflislslvl 121 igygsvsgfy asvkcantnf pqhrgtagaf pvslyglsgm vfsylcsklf geniehvfif 181 lmvacgcmil vgyfsldifs naegddasik ewelqksret ddnivplyen sndyigspvr 241 ssspatyety alsdnfqets effaledrql snrpllspss phtkydfede ntskntvgen 301 saqksmrlhv fqslksstfi gyyivlgilq gvglmyiysv gfmvqaqvst pplnqlpina 361 ekiqslqvtl lsllsfcgrl ssgpisdflv kkfkaqrlwn iviasllvfl asnkishdfs 421 siedpslras ksfknisvcs aifgysfgvl fgtfpsivad rfgtngystl wgvlttggvf 481 svsvftdilg rdfkantgdd dgnckkgvlc ysytfmvtky caafnllfvl giigytyyrr 541 ratansl // LOCUS NP_013877 238 aa linear PLN 30-JUN-2025 DEFINITION polynucleotide 3'-phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013877 VERSION NP_013877.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182659.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10051. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..238 /product="polynucleotide 3'-phosphatase" /EC_number="3.1.3.32" /calculated_mol_wt="27252" Region 30..236 /region_name="Haloacid Dehalogenase-like Hydrolases" /note="The haloacid dehalogenase (HAD) superfamily includes carbon and phosphorus hydrolases such as 2-haloalkonoate dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, among others. These...; cl21460" /db_xref="CDD:473868" Site order(35..39,88..89,170,205..206,217..218) /site_type="active" /db_xref="CDD:319763" CDS 1..238 /gene="TPP1" /locus_tag="YMR156C" /coded_by="NM_001182659.1:1..717" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:11278831|PMID:15222769]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:15222769]" /experiment="EXISTENCE:direct assay:GO:0046403 polynucleotide 3'-phosphatase activity [PMID:11278831]" /experiment="EXISTENCE:genetic interaction:GO:0006302 double-strand break repair [PMID:11585902]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:11585902]" /experiment="EXISTENCE:mutant phenotype:GO:0046403 polynucleotide 3'-phosphatase activity [PMID:15222769]" /note="DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3'-phosphatase" /db_xref="GeneID:855188" /db_xref="SGD:S000004765" ORIGIN 1 mshkltilpf likftpkfpq sidhdehgln vyafdldhti ikpkspnisf srsasdwqfi 61 nfnskkstld ylcniidndp tavivifsnq ggvitvprts ksctkytnki llflkaiknd 121 ergetlshrl wlyaapkrpk tfaanhskit faslgesynn dpnifekvrk pmtgmveffk 181 rdlesayrvs eqispiklnw iyycgdaagr kkdfsdsdik faenlhvefk ypeeifhg // LOCUS NP_013878 255 aa linear PLN 30-JUN-2025 DEFINITION Aim36p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013878 VERSION NP_013878.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182660.1 REFERENCE 1 (residues 1 to 255) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 255) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 255) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 255) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10052. Method: conceptual translation. FEATURES Location/Qualifiers source 1..255 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..255 /product="Aim36p" /calculated_mol_wt="28946" CDS 1..255 /gene="AIM36" /locus_tag="YMR157C" /gene_synonym="FMP39" /coded_by="NM_001182660.1:1..768" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961|PMID:24769239]" /note="hypothetical protein; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies" /db_xref="GeneID:855189" /db_xref="SGD:S000004766" ORIGIN 1 mlrplrksvl ascrhcfkvc gglpqkqlpl fsplllrary sstdsstkrs nksdkidapg 61 fkkiflvaii gtvifvktvq sldknkpktt lseeefenvv kglkrrvaif pqgevdikfs 121 lspsieetrk vlqksqgddi nelqfvdpvk vidyyrtlrd dryeallney ykkygcdtya 181 ynlptgmlvm llgryfkenf ktgdklvvvn fphsiadatr fenevsivsk ifvprklsgs 241 dvckyyetvg kadii // LOCUS NP_013879 155 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS8m MRPS8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013879 VERSION NP_013879.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182661.1 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10053. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..155 /product="mitochondrial 37S ribosomal protein uS8m MRPS8" /calculated_mol_wt="17339" Region 6..154 /region_name="Ribosomal_S8" /note="Ribosomal protein S8; cl00330" /db_xref="CDD:444841" CDS 1..155 /gene="MRPS8" /locus_tag="YMR158W" /gene_synonym="uS8m" /coded_by="NM_001182661.1:1..468" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:855190" /db_xref="SGD:S000004767" ORIGIN 1 mslvklantc ahlqncskvr valtsipytk lqlqfaynly qqgflsslqk gstmgpdkdf 61 vevtpdnist rrlwvglkyr dnkpvlssck liskpnsrih lpmedmkklc sgvtirnikp 121 lqpgelilvr ahnnimdine aiskkldgev lcrvk // LOCUS NP_013880 45 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR158C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013880 VERSION NP_013880.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184342.1 REFERENCE 1 (residues 1 to 45) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 45) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 45) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 45) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 45) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 45) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 45) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10054. Method: conceptual translation. FEATURES Location/Qualifiers source 1..45 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..45 /product="uncharacterized protein" /calculated_mol_wt="5149" CDS 1..45 /locus_tag="YMR158C-A" /gene_synonym="YMR158C-B" /coded_by="NM_001184342.1:1..138" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /note="hypothetical protein; may contain a lipid attachment site; localizes to cytosol, and to peroxisomes in oleate-growing cells; YMR158C-A is not an essential gene" /db_xref="GeneID:855192" /db_xref="SGD:S000007249" ORIGIN 1 mkmnyhlsts syttsmlsct vldddiryek lswkldeaem qglim // LOCUS NP_013882 150 aa linear PLN 30-JUN-2025 DEFINITION Atg16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013882 VERSION NP_013882.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182663.1 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10055. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..150 /product="Atg16p" /calculated_mol_wt="17091" Region 2..53 /region_name="Atg16_NTD" /note="N-terminal domain of Saccharomyces cerevisiae autophagy-related protein 16 (Atg16); cd22882" /db_xref="CDD:439374" Site order(24..25,29,31..33,35..36,38..43,45..49,53) /site_type="other" /note="Atg5 binding site [polypeptide binding]" /db_xref="CDD:439374" Region 59..145 /region_name="Atg16_CCD" /note="Coiled-coiled domain of autophagy-related 16 (Atg16) family proteins; cd22887" /db_xref="CDD:439196" Site order(61,64..65,67..68,71,74..75,78..79,81..82,85..86,89, 92..93,96,99..100,102..103,106,109..110,113..114,116..117, 120..121,123..124,127..128,130..131,134) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:439196" CDS 1..150 /gene="ATG16" /locus_tag="YMR159C" /gene_synonym="APG15; APG16; CVT11; SAP18" /coded_by="NM_001182663.1:1..453" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:11689437]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016236 macroautophagy [PMID:11897782]" /experiment="EXISTENCE:direct assay:GO:0034274 Atg12-Atg5-Atg16 complex [PMID:11897782]" /experiment="EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006501 C-terminal protein lipidation [PMID:17192262]" /experiment="EXISTENCE:mutant phenotype:GO:0019776 Atg8-family ligase activity [PMID:17192262]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:11897782]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:17192262]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:1905037 autophagosome organization [PMID:24485455]" /experiment="EXISTENCE:physical interaction:GO:0034274 Atg12-Atg5-Atg16 complex [PMID:10406794]" /note="Conserved protein involved in autophagy; interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which binds to membranes and localizes to the pre-autophagosomal structure and are required for autophagy; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:855194" /db_xref="SGD:S000004769" ORIGIN 1 mgnfiiterk kakeersnpq tdsmddllir rltdrndkea hlnelfqdns gaiggnivsh 61 ddallntlai lqkelkskeq eirrlkevia lknknterln delisgtien nvlqqklsdl 121 kkehsqlvar wlkktekete amnseidgtk // LOCUS NP_013883 816 aa linear PLN 30-JUN-2025 DEFINITION Cvm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013883 VERSION NP_013883.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182664.1 REFERENCE 1 (residues 1 to 816) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 816) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 816) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 816) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 816) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10056. Method: conceptual translation. FEATURES Location/Qualifiers source 1..816 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..816 /product="Cvm1p" /calculated_mol_wt="94966" CDS 1..816 /gene="CVM1" /locus_tag="YMR160W" /coded_by="NM_001182664.1:1..2451" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:35766971]" /experiment="EXISTENCE:direct assay:GO:0098853 endoplasmic reticulum-vacuole membrane contact site [PMID:35766971]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:35766971]" /experiment="EXISTENCE:mutant phenotype:GO:0006665 sphingolipid metabolic process [PMID:35766971]" /note="Protein involved in sphingolipid metabolism; localizes to vacuolar contact sites with mitochondria, ER and peroxisomes; mutant has enhanced sensitivity to overexpression of mutant huntingtin; relative distribution within the vacuolar membrane changes upon DNA replication stress" /db_xref="GeneID:855195" /db_xref="SGD:S000004770" ORIGIN 1 mdvvqqkqdk qlqhqtqeqq qiredqqevp pqrprqqnrw kpwwnstadd epntgriaey 61 pngqgrsspt tdfqdsvnsn ndnkgiwski asfatsryrs apivvddntr ysqlnteqin 121 fleneakdii skkskswcwy eaiphisnss niidsidtpg iisvsgtgsa kcplplnkyp 181 geggnpgynv findslilps dnplnflhvq plrtkvlnti knyynfpneq hlylrqkkta 241 llkdkriiii svvgdlpeky eqrslesqrs ayylsrklsq nlaqeqpqrv ltlsfqcplh 301 nqdliptyke cvellnhwah lfkevdsiff vgvyhsvplt lllakyivqn nevlefdent 361 tvsvlsfqsc lqgyrfwdhs tdftsnsynn lgsnsstnen dsndhdsnnd fttksqqike 421 kqlfqgidkk qqdtlskikn yrridssesk lvqdaldwll fnwdtfrltf fgklydnfmt 481 iseklaidyn hpkilrnlwc ngkymgidlk nannlnldtd deatsnindv hvrtpnfesr 541 lkiptnrlfe itlwdilmit enlgykqfip iinllspffi srsfndytlp pnirkqyqns 601 nkiwlqemds kwkmnghqln ydqregeslg sssesllpen istvkdflqf vqyqnekssd 661 fvriysdiyd ddkvykcfly ntiftknpls rkhlrlnidl dtptsilntv nqydlvwkih 721 dsfskliqlk nlpqreipha lrlsislncf ldsttstsgp vfqrdtveal rrlteiwrty 781 qdwspptrgl khlrdilsvl amydnpknli ndvrrt // LOCUS NP_013884 224 aa linear PLN 30-JUN-2025 DEFINITION type I HSP40 co-chaperone HLJ1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013884 VERSION NP_013884.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182665.1 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10057. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..224 /product="type I HSP40 co-chaperone HLJ1" /calculated_mol_wt="24877" Region 22..>154 /region_name="DnaJ_bact" /note="chaperone protein DnaJ; TIGR02349" /db_xref="CDD:274090" CDS 1..224 /gene="HLJ1" /locus_tag="YMR161W" /coded_by="NM_001182665.1:1..675" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:15342786]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12514182]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:15252059|PMID:15342786]" /note="Co-chaperone for Hsp40p; anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ" /db_xref="GeneID:855196" /db_xref="SGD:S000004771" ORIGIN 1 msftedqeki aleilskdkh efyeilkvdr katdseikka yrklaiklhp dknshpkage 61 afkvinrafe vlsneekrsi ydrigrdpdd rqmpsrgaas gfrgsaggsp mgggfedmff 121 nsrfggqrag ppedifdflf naggspfgas pfgpsastfs fggpggfrvy tnnrggspfm 181 rqqprsrqqq qqaeenavns qlknmlvlfi ifivlpmikd ylfs // LOCUS NP_013885 1656 aa linear PLN 30-JUN-2025 DEFINITION aminophospholipid-translocating P4-type ATPase DNF3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013885 VERSION NP_013885.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182666.1 REFERENCE 1 (residues 1 to 1656) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1656) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1656) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1656) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10058. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1656 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1656 /product="aminophospholipid-translocating P4-type ATPase DNF3" /EC_number="7.6.2.1" /calculated_mol_wt="188189" Region 140..1386 /region_name="P-type_ATPase_APLT_Dnf-like" /note="Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; cd02073" /db_xref="CDD:319770" Site order(566..568,813,838..840,1067,1114..1116,1202,1205,1208, 1229,1232) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:319770" CDS 1..1656 /gene="DNF3" /locus_tag="YMR162C" /coded_by="NM_001182666.1:1..4971" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:17093059]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:32661085]" /experiment="EXISTENCE:direct assay:GO:0030140 trans-Golgi network transport vesicle [PMID:12221123]" /experiment="EXISTENCE:direct assay:GO:0070867 mating projection tip membrane [PMID:25378585]" /experiment="EXISTENCE:genetic interaction:GO:0090555 phosphatidylethanolamine flippase activity [PMID:16452632]" /experiment="EXISTENCE:genetic interaction:GO:0140345 phosphatidylcholine flippase activity [PMID:16452632]" /experiment="EXISTENCE:genetic interaction:GO:0140346 phosphatidylserine flippase activity [PMID:16452632]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:32661085]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:32661085|PMID:16452632]" /experiment="EXISTENCE:mutant phenotype:GO:0090555 phosphatidylethanolamine flippase activity [PMID:16452632]" /experiment="EXISTENCE:mutant phenotype:GO:0140345 phosphatidylcholine flippase activity [PMID:16452632]" /experiment="EXISTENCE:mutant phenotype:GO:0140346 phosphatidylserine flippase activity [PMID:32661085]" /note="Trans-golgi network aminophospholipid translocase (flippase); type 4 P-type ATPase; involved in phospholipid translocation, contributing to the maintenance of membrane lipid asymmetry in post-Golgi secretory vesicles; role in protein trafficking between the Golgi and endosomal system; localizes to the trans-Golgi network; localizes to the shmoo tip where it has a redundant role in the cellular response to mating pheromone" /db_xref="GeneID:855197" /db_xref="SGD:S000004772" ORIGIN 1 mgiadgqrrr ssslrtqmfn khlydkyrgr tddeieledi nesktfsgsd nndkddrdet 61 sgnyaaeedy emeeygspdv sysiitkild tildrrrtfh skdgrhipii ldhnaieykq 121 aatkrdghli derfnkpycd nritssrytf ysflprqlya qfsklantyf fivavlqmip 181 gwsttgtytt iiplcvfmgi smtreawddf rrhrldkeen nkpvgvlvkd gnndaqevyt 241 lpssvvssta yltksaaaen npplnddrns sqghfldthf nnfellknky nvhihqkkwe 301 klrvgdfvll tqddwvpadl llltcdgens ecfvetmald getnlkskqp hpelnkltka 361 asglaninaq vtvedpnidl ynfegnlelk nhrndtimky plgpdnviyr gsilrntqnv 421 vgmvifsgee tkirmnalkn prtkapklqr kinmiivfmv fvvatislfs ylghvlhkkk 481 yidqnkawyl fqadagvapt imsfiimynt viplslyvtm eiikvvqskm mewdidmyha 541 etntpcesrt atileelgqv syifsdktgt ltdnkmifrk fslcgsswlh nvdlgnsedn 601 fednrdntns lrlppkahng ssidvvsigd qnvldrlgfs dapiekghrp sldnfpksrn 661 sieykgnssa iytgrpsmrs lfgkdnshls kqasvispse tfsenikssf dliqfiqryp 721 talfsqkakf fflslalchs clpkkthnes igedsieyqs sspdelalvt aardlgyivl 781 nrnaqiltik tfpdgfdgea klenyeilny idfnsqrkrm svlvrmpnqp nqvllickga 841 dnvimerlhd relaakkmad ictstkerkd aeaelvlqqr kslermvdee amartslrns 901 lssvprasls lqavrkslsm knsrtrdpek qidsidqfle tvkksdqeig svvnksrksl 961 hkqqiekygp risidgthfp nnnvpidtrk eglqhdydte ilehigsdel ilneeyvier 1021 tlqaidefst eglrtlvyay kwidigqyen wnkryhqakt sltdrkikvd eagaeiedgl 1081 nllgvtaied klqdgvseai ekirragikm wmltgdkret ainigyscml ikdystvvil 1141 tttdeniisk mnavsqevds gniahcvvvi dgatmamfeg nptymsvfve lctktdsvic 1201 craspsqkal mvsnirntdp nlvtlaigdg andiamiqsa digvgiagke glqasrvsdy 1261 sigqfrfllk llfvhgryny irtskfmlct fykeitfyft qliyqrytmf sgsslyepws 1321 lsmfntlfts lpvlcigmfe kdlkpmtllt vpelysygrl sqgfnwlifm ewvilattns 1381 liitflnvvm wgmsslsdnt myplglinft aivalinvks qfvemhnrnw laftsvvlsc 1441 ggwlvwccal pilnntdqiy dvaygfynhf gkditfwcts lvlallpitl divyktfkvm 1501 iwpsdsdifa eleqksdirk klelgaysem rqgwtwdkdp stftrytdkv lsrprtnsra 1561 sakthnssiy smsngnvdhs skknffgnss kksseryevl psgklikrps lktqsskdsi 1621 ggnittkltk klklpsrnve dedvnqiiqa rlkdle // LOCUS NP_013886 705 aa linear PLN 30-JUN-2025 DEFINITION Inp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013886 VERSION NP_013886.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182667.1 REFERENCE 1 (residues 1 to 705) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 705) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 705) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 705) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10059. Method: conceptual translation. FEATURES Location/Qualifiers source 1..705 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..705 /product="Inp2p" /calculated_mol_wt="81336" CDS 1..705 /gene="INP2" /locus_tag="YMR163C" /coded_by="NM_001182667.1:1..2118" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:16678774]" /experiment="EXISTENCE:genetic interaction:GO:0045033 peroxisome inheritance [PMID:16678774]" /experiment="EXISTENCE:mutant phenotype:GO:0043495 protein-membrane adaptor activity [PMID:16678774]" /experiment="EXISTENCE:mutant phenotype:GO:0045033 peroxisome inheritance [PMID:16678774]" /experiment="EXISTENCE:physical interaction:GO:0043495 protein-membrane adaptor activity [PMID:16678774]" /experiment="EXISTENCE:physical interaction:GO:0045033 peroxisome inheritance [PMID:16678774]" /note="Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene" /db_xref="GeneID:855198" /db_xref="SGD:S000004773" ORIGIN 1 mttnsrpsal qapglqifsm lksseedgfm sssltldsdn iigvtennrq efystwrkps 61 llssrsvlhe ysptivgsnd ctfspitvgk ttkffnwddi isrifmqqpf gvthqffeef 121 rysiitshfl ndmnhyrlsl hldqsimnfh ksstllknvp pksvpfmatk ygklavaedk 181 klyfrqnfny lsmiitsyrv ltqlkkycrk knspglkrvv ililvavyls iqqeyfrrhl 241 icyktllkvr kvleslqqvd vmihkyhlrf keiknhsfis rvslisiade hssvikellv 301 fssdalfykl ksiipdivif sdtselskyc elygidvpnl yynntttvkd ldgklyrlkl 361 lkkfmlccll sldmtgnenl snvnmrnaln kifpdymarv qlkkkynpig tfqnivsllr 421 glhsllstvl vslndhkqil yafpeetstn tgceranvcs fskndklfqa lnylkmienn 481 llaidirngi tendrniied kleelitfwk tskicgnisr iqkvsptnti nhgfhldilk 541 grksprsssv qglslerkvd fidvaesvnd sfendtelee yedydcqeec sagsrqnhrv 601 dfigkdscrk pdfkqlsdne lrrklderil klaqenregr erlrtaksfe llrkaqasms 661 vkfgfqkplr ddaflesrpl skckvsseet ipflyelkgl lgnds // LOCUS NP_013887 758 aa linear PLN 30-JUN-2025 DEFINITION Mss11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013887 VERSION NP_013887.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182668.1 REFERENCE 1 (residues 1 to 758) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 758) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 758) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 758) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10060. Method: conceptual translation. FEATURES Location/Qualifiers source 1..758 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..758 /product="Mss11p" /calculated_mol_wt="84919" Region 54..78 /region_name="LisH" /note="pfam08513" /db_xref="CDD:462501" CDS 1..758 /gene="MSS11" /locus_tag="YMR164C" /coded_by="NM_001182668.1:1..2277" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:10515942]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9987114|PMID:10515942]" /experiment="EXISTENCE:direct assay:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:9987114]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15466424]" /experiment="EXISTENCE:genetic interaction:GO:1900735 positive regulation of flocculation [PMID:15466424]" /experiment="EXISTENCE:genetic interaction:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:15466424]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16568252|PMID:9342405|PMID:9987114|PMID:15466424]" /experiment="EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:15466424|PMID:16568252|PMID:9987114]" /experiment="EXISTENCE:mutant phenotype:GO:2000222 positive regulation of pseudohyphal growth [PMID:9987114]" /experiment="EXISTENCE:mutant phenotype:GO:2000883 positive regulation of starch catabolic process [PMID:9342405|PMID:9987114]" /note="Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1" /db_xref="GeneID:855200" /db_xref="SGD:S000004774" ORIGIN 1 mdnttnintn erssntdfss apnikglnsh tqlqfdadsr vfvsdvmakn skqllyahiy 61 nyliknnywn saakflsead lplsringsa sggktslnas lkqglmdias kgdivsedgl 121 lpskmlmdan dtfllewwei fqslfngdle sgyqqdhnpl reriipilpa nsksnmpshf 181 snlppnvipp tqnsfpvsee sfrpngdgsn fnlndptnrn vserflsrts gvydkqnsan 241 fapdtainsd iagqqyatin lhkhfndlqs paqpqqssqq qiqqpqhqpq hqpqqqqqqq 301 qqqqqqqqqq qqqqqqqqqq qqqhqqqqqt pypivnpqmv phipsenshs tglmpsvppt 361 nqqfnaqtqs smfsdqqrff qyqlhhqnqg qapsfqqsqs grfddmnamk mffqqqalqq 421 nslqqnlgnq nyqsntrnnt aeettptndn nangnsllqe hirarfnkmk tipqqmknqs 481 tvanpvvsdi tsqqqymhmm mqrmaanqql qnsafppdtn riapanntmp lqpgnmgspv 541 ienpgmrqtn psgqnpminm qplyqnvssa mhafapqqqf hlpqhyktnt svpqndstsv 601 fplpnnnnnn nnnnnnnnnn nsnnsnnnnn nnnnnnnsnn tptvsqpssk ctssssttpn 661 itttiqpkrk qrvgktktke srkvaaaqkv mkskkleqng dsaatnfinv tpkdsggkgt 721 vkvqnsnsqq qlngsfsmdt etfdifnigd fspdlmds // LOCUS NP_013888 862 aa linear PLN 30-JUN-2025 DEFINITION phosphatidate phosphatase PAH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013888 VERSION NP_013888.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182669.1 REFERENCE 1 (residues 1 to 862) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 862) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 862) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 862) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10061. Method: conceptual translation. FEATURES Location/Qualifiers source 1..862 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..862 /product="phosphatidate phosphatase PAH1" /EC_number="3.1.3.4" /calculated_mol_wt="94900" Region 1..103 /region_name="Lipin_N" /note="lipin, N-terminal conserved region; pfam04571" /db_xref="CDD:461356" Region 349..583 /region_name="LNS2" /note="LNS2 (Lipin/Ned1/Smp2); pfam08235" /db_xref="CDD:462403" CDS 1..862 /gene="PAH1" /locus_tag="YMR165C" /gene_synonym="SMP2" /coded_by="NM_001182669.1:1..2589" /experiment="EXISTENCE:direct assay:GO:0000976 transcription cis-regulatory region binding [PMID:15889145]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005773 vacuole [PMID:22121197]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:26275961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:16467296]" /experiment="EXISTENCE:direct assay:GO:0006651 diacylglycerol biosynthetic process [PMID:39009344]" /experiment="EXISTENCE:direct assay:GO:0008195 phosphatidate phosphatase activity [PMID:35026226|PMID:39009344|PMID:16467296]" /experiment="EXISTENCE:direct assay:GO:0031965 nuclear membrane [PMID:35026226|PMID:20876142]" /experiment="EXISTENCE:genetic interaction:GO:0019432 triglyceride biosynthetic process [PMID:24196957]" /experiment="EXISTENCE:genetic interaction:GO:0034389 lipid droplet organization [PMID:21829381]" /experiment="EXISTENCE:mutant phenotype:GO:0006276 plasmid maintenance [PMID:8437575]" /experiment="EXISTENCE:mutant phenotype:GO:0008195 phosphatidate phosphatase activity [PMID:16467296]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:35026226|PMID:16467296|PMID:17971454]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8437575]" /experiment="EXISTENCE:mutant phenotype:GO:0019432 triglyceride biosynthetic process [PMID:35026226|PMID:24196957]" /experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:21422231]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:22121197]" /note="Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; regulates phospholipid synthesis, nuclear/ER membrane growth, lipid droplet formation, triacylglycerol synthesis, vacuolar homeostasis and cell wall integrity; phosphorylated by Hsl1p, Pho85p/Pho80p, Cdc28p/Cyclin B, PKA, PKC, and CKII, regulating activity, localization, and proteosomal degradation; homolog of mammalian lipins 1 and 2; human homologs LPIN1, LPIN2, LPIN3 complement the null" /db_xref="GeneID:855201" /db_xref="SGD:S000004775" ORIGIN 1 mqyvgralgs vsktwssinp atlsgaidvi vvehpdgrls cspfhvrfgk fqilkpsqkk 61 vqvfinekls nmpmklsdsg eayfvfemgd qvtdvpdell vspvmsatss ppqspetsil 121 eggtegegeg enenkkkekk vleepdfldi ndtgdsgskn settgslspt esstttppds 181 veerklveqr tknfqqklnk klteihipsk ldnngdllld tegykpnknm mhdtdiqlkq 241 llkdefgnds dissfikedk ngnikivnpy ehltdlsppg tpptmatsgs vlgldamesg 301 stlnslsssp sgsdtedets fskeqsskse ktskkgtags getekryirt irltndqlkc 361 lnltygendl kfsvdhgkai vtsklfvwrw dvpivisdid gtitksdalg hvlamigkdw 421 thlgvaklfs eisrngynil yltarsagqa dstrsylrsi eqngsklpng pvilspdrtm 481 aalrrevilk kpevfkiacl ndirslyfed sdnevdteek stpffagfgn ritdalsyrt 541 vgipssrift integevhme llelagyrss yihinelvdh ffppvsldsv dlrtntsmvp 601 gsppnrtldn fdseitsgrk tlfrgnqeek ftdvnfwrdp lvdidnlsdi snddsdnide 661 dtdvsqqsni srnransvkt akvtkapqrn vsgstnnnev laassdvena sdlvsshsss 721 gstpnkstms kgdigkqiyl elgsplaspk lrylddmdde dsnynrtksr rassaaatsi 781 dkefkklsvs kagaptrivs kinvsndvhs lgnsdtesrr eqsvnetgrn qlphnsmddk 841 dldsrvsdef dddefdedef ed // LOCUS NP_013889 368 aa linear PLN 30-JUN-2025 DEFINITION Mme1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013889 VERSION NP_013889.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182670.1 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10062. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..368 /product="Mme1p" /calculated_mol_wt="40861" Region 51..142 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 55..>283 /region_name="PTZ00168" /note="mitochondrial carrier protein; Provisional" /db_xref="CDD:185494" Region 252..363 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..368 /gene="MME1" /locus_tag="YMR166C" /coded_by="NM_001182670.1:1..1107" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:25585246]" /experiment="EXISTENCE:direct assay:GO:0015095 magnesium ion transmembrane transporter activity [PMID:25585246]" /experiment="EXISTENCE:direct assay:GO:0015693 magnesium ion transport [PMID:25585246]" /experiment="EXISTENCE:mutant phenotype:GO:1990616 magnesium ion export from mitochondrion [PMID:25585246]" /note="Transporter of the mitochondrial inner membrane that exports magnesium; involved in mitochondrial Mg2+ homeostasis; has similarity to human mitochondrial ATP-Mg/Pi carriers" /db_xref="GeneID:855202" /db_xref="SGD:S000004776" ORIGIN 1 mnswnlsssi piihtphdhp ptsegtpdqp nnnrkddklh kkrgdsdedl spiwhcvvsg 61 giggkigdsa mhsldtvktr qqgapnvkky rnmisayrti wleegvrrgl yggymaamlg 121 sfpsaaiffg tyeytkrtmi edwqindtit hlsagflgdf issfvyvpse vlktrlqlqg 181 rfnnpffqsg ynysnlrnai ktvikeegfr slffgykatl ardlpfsalq fafyekfrql 241 afkieqkdgr dgelsipnei ltgacaggla giittpmdvv ktrvqtqqpp sqsnksysvt 301 hphvtngrpa alsnsislsl rtvyqsegvl gffsgvgprf vwtsvqssim lllyqmtlrg 361 lsnafptd // LOCUS NP_013890 769 aa linear PLN 30-JUN-2025 DEFINITION mismatch repair ATPase MLH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013890 VERSION NP_013890.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182671.1 REFERENCE 1 (residues 1 to 769) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 769) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 769) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 769) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10063. Method: conceptual translation. FEATURES Location/Qualifiers source 1..769 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..769 /product="mismatch repair ATPase MLH1" /calculated_mol_wt="86932" Region 4..315 /region_name="mutl" /note="DNA mismatch repair protein MutL; TIGR00585" /db_xref="CDD:273155" Region 510..769 /region_name="Mlh1_C" /note="DNA mismatch repair protein Mlh1 C-terminus; pfam16413" /db_xref="CDD:465109" CDS 1..769 /gene="MLH1" /locus_tag="YMR167W" /gene_synonym="PMS2" /coded_by="NM_001182671.1:1..2310" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:11717305]" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:23316435|PMID:16702432]" /experiment="EXISTENCE:mutant phenotype:GO:0000713 meiotic heteroduplex formation [PMID:15654114]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:10938116]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:2685551]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10570173]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:11717305]" /experiment="EXISTENCE:physical interaction:GO:0032389 MutLalpha complex [PMID:8066446|PMID:10570173|PMID:11237696]" /experiment="EXISTENCE:physical interaction:GO:0032390 MutLbeta complex [PMID:10570173]" /experiment="EXISTENCE:physical interaction:GO:0097587 MutLgamma complex [PMID:9770499|PMID:10570173]" /note="Protein required for mismatch repair in mitosis and meiosis; also required for crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; required for silencing at the silent mating-type loci and telomeres; human homolog is associated with hereditary non-polyposis colon cancer" /db_xref="GeneID:855203" /db_xref="SGD:S000004777" ORIGIN 1 mslrikalda svvnkiaage iiispvnalk emmensidan atmidilvke ggikvlqitd 61 ngsginkadl pilcerftts klqkfedlsq iqtygfrgea lasishvarv tvttkvkedr 121 cawrvsyaeg kmlespkpva gkdgttilve dlffnipsrl ralrshndey skildvvgry 181 aihskdigfs ckkfgdsnys lsvkpsytvq drirtvfnks vasnlitfhi skvedlnles 241 vdgkvcnlnf iskksispif finnrlvtcd llrralnsvy snylpkgnrp fiylgividp 301 aavdvnvhpt krevrflsqd eiiekianql haelsaidts rtfkassist nkpeslipfn 361 dtiesdrnrk slrqaqvven syttansqlr kakrqenklv ridasqakit sflsssqqfn 421 fegsstkrql sepkvtnvsh sqeaekltln eseqprdant indndlkdqp kkkqklgdyk 481 vpsiaddekn alpiskdgyi rvpkervnvn ltsikklrek vddsihrelt difanlnyvg 541 vvdeerrlaa iqhdlklfli dygsvcyelf yqigltdfan fgkinlqstn vsddivlynl 601 lsefdelndd askekiiski wdmssmlney ysielvndgl dndlksvklk slplllkgyi 661 pslvklpffi yrlgkevdwe deqecldgil reiallyipd mvpkvdtsda slsedekaqf 721 inrkehissl lehvlfpcik rrflaprhil kdvveianlp dlykvferc // LOCUS NP_013891 608 aa linear PLN 30-JUN-2025 DEFINITION Cep3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013891 VERSION NP_013891.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182672.1 REFERENCE 1 (residues 1 to 608) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 608) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 608) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 608) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10064. Method: conceptual translation. FEATURES Location/Qualifiers source 1..608 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..608 /product="Cep3p" /calculated_mol_wt="71227" Site order(9,13,18..21,23,26,35) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Region 12..48 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(14,17,24,30,33) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 55..606 /region_name="Cep3_C" /note="C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3; cd12147" /db_xref="CDD:213390" Site order(88..92,139,153..155,159,218,221..222,224..228, 230..232,235,251..252,255..256,258..259,262,265..268, 281..282,285..286,288..289,306..307,309..310) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:213390" CDS 1..608 /gene="CEP3" /locus_tag="YMR168C" /gene_synonym="CBF3; CSL1" /coded_by="NM_001182672.1:1..1827" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:10352012]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:10097110]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:10352012]" /experiment="EXISTENCE:direct assay:GO:0031518 CBF3 complex [PMID:8670864|PMID:1997204|PMID:8706132]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:16330709]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:11290706]" /note="Essential kinetochore protein; component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain" /db_xref="GeneID:855204" /db_xref="SGD:S000004778" ORIGIN 1 mfnrttqlks khpcsvctrr kvkcdrmipc gncrkrgqds ecmkstklit assskeylpd 61 lllfwqnyey witniglykt kqrdltrtpa nldtdteecm fwmnylqkdq sfqlmnfame 121 nlgalyfgsi gdiselylrv eqywdrradk nhsvdgkywd aliwsvftmc iyympvekla 181 eifsvyplhe ylgsnkrlnw edgmqlvmcq nfarcslfql kqcdfmahpd irlvqaylil 241 atttfpydep llanslltqc ihtfknfhvd dfrpllnddp vesiakvtlg rifyrlcgcd 301 ylqsgprkpi alhtevssll qhaaylqdlp nvdvyreens tevlywkiis ldrdldqyln 361 ksskpplktl dairreldif qykvdsleed frsnnsrfqk fialfqistv swklfkmyli 421 yydtadsllk vihyskviis livnnfhaks effnrhpmvm qtitrvvsfi sfyqifvesa 481 avkqllvdlt eltanlptif gskldklvyl terlsklkll wdkvqlldsg dsfyhpvfki 541 lqndikiiel kndemfslik glgslvplnk lrqeslleee denntepsdf rtiveefqse 601 ynisdils // LOCUS NP_013892 506 aa linear PLN 30-JUN-2025 DEFINITION aldehyde dehydrogenase (NAD(+)) ALD3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013892 VERSION NP_013892.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182673.1 REFERENCE 1 (residues 1 to 506) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 506) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 506) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 506) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10065. Method: conceptual translation. FEATURES Location/Qualifiers source 1..506 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..506 /product="aldehyde dehydrogenase (NAD(+)) ALD3" /EC_number="1.2.1.3" /calculated_mol_wt="55254" Region 14..502 /region_name="ALDH-SF" /note="NAD(P)+-dependent aldehyde dehydrogenase superfamily; cl11961" /db_xref="CDD:448367" Site order(165..169,177,192,194..195,243..246,249,252..253, 268..270,302,406,408,434,472) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:143395" Site order(169,268,299,302) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:143395" CDS 1..506 /gene="ALD3" /locus_tag="YMR169C" /coded_by="NM_001182673.1:1..1521" /experiment="EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:10407263]" /experiment="EXISTENCE:mutant phenotype:GO:0006598 polyamine catabolic process [PMID:12586697]" /experiment="EXISTENCE:mutant phenotype:GO:0019483 beta-alanine biosynthetic process [PMID:12586697]" /note="Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose" /db_xref="GeneID:855205" /db_xref="SGD:S000004779" ORIGIN 1 mptlytdiei pqlkislkqp lglfinnefc pssdgktiet vnpatgepit sfqaanekdv 61 dkavkaaraa fdnvwsktss eqrgiylsnl lklieeeqdt laaletldag kpfhsnakqd 121 laqiieltry yagavdkfnm getipltfnk faytlkvpfg vvaqivpwny plamacrkmq 181 galaagntvi ikpaentsls llyfatlikk agfppgvvnv ipgygsvvgk algthmdidk 241 isftgstkvg gsvleasgqs nlkditlecg gkspalvfed adldkaiewv angiffnsgq 301 ictansrvyv qssiydkfve kfketakkew dvagkfdpfd ekcivgpvis stqydriksy 361 iergkkeekl dmfqtsefpi ggakgyfipp tiftdvpets kllrdeifgp vvvvskftny 421 ddalklandt cyglasavft kdvkkahmfa rdikagtvwi nqtnqeeakv pfggfkmsgi 481 gresgdtgvd nylqiksvhv dlsldk // LOCUS NP_013893 506 aa linear PLN 30-JUN-2025 DEFINITION aldehyde dehydrogenase (NAD(+)) ALD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013893 VERSION NP_013893.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182674.1 REFERENCE 1 (residues 1 to 506) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 506) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 506) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 506) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10066. Method: conceptual translation. FEATURES Location/Qualifiers source 1..506 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..506 /product="aldehyde dehydrogenase (NAD(+)) ALD2" /EC_number="1.2.1.3" /calculated_mol_wt="55057" Region 14..502 /region_name="ALDH_ALD2-YMR170C" /note="Saccharomyces cerevisiae aldehyde dehydrogenase 2 (YMR170c)-like; cd07144" /db_xref="CDD:143462" Site order(165..166,168..169,192,195,224..225,229..230,243..246, 249,252..253,268..270,302,406,408,434,472) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:143462" Site order(169,268,299,302) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:143462" CDS 1..506 /gene="ALD2" /locus_tag="YMR170C" /coded_by="NM_001182674.1:1..1521" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:12586697]" /experiment="EXISTENCE:mutant phenotype:GO:0006598 polyamine catabolic process [PMID:12586697]" /experiment="EXISTENCE:mutant phenotype:GO:0019483 beta-alanine biosynthetic process [PMID:12586697]" /note="Cytoplasmic aldehyde dehydrogenase; involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p" /db_xref="GeneID:855206" /db_xref="SGD:S000004780" ORIGIN 1 mptlytdiei pqlkislkqp lglfinnefc pssdgktiet vnpatgepit sfqaanekdv 61 dkavkaaraa fdnvwsktss eqrgiylsnl lklieeeqdt laaletldag kpyhsnakgd 121 laqilqltry fagsadkfdk gatipltfnk faytlkvpfg vvaqivpwny plamacwklq 181 galaagntvi ikpaentsls llyfatlikk agfppgvvni vpgygslvgq alashmdidk 241 isftgstkvg gfvleasgqs nlkdvtlecg gkspalvfed adldkaidwi aagifynsgq 301 nctansrvyv qssiydkfve kfketakkew dvagkfdpfd ekcivgpvis stqydriksy 361 iergkreekl dmfqtsefpi ggakgyfipp tiftdvpqts kllqdeifgp vvvvskftny 421 ddalklandt cyglasavft kdvkkahmfa rdikagtvwi nssndedvtv pfggfkmsgi 481 grelgqsgvd tylqtkavhi nlsldn // LOCUS NP_013894 550 aa linear PLN 30-JUN-2025 DEFINITION Ear1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013894 VERSION NP_013894.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182675.1 REFERENCE 1 (residues 1 to 550) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 550) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 550) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 550) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 550) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 550) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 550) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10067. Method: conceptual translation. FEATURES Location/Qualifiers source 1..550 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..550 /product="Ear1p" /calculated_mol_wt="62401" Region 185..374 /region_name="SPRY_SSH4_like" /note="SPRY domain in SSH4 and similar proteins; cd12910" /db_xref="CDD:293967" CDS 1..550 /gene="EAR1" /locus_tag="YMR171C" /coded_by="NM_001182675.1:1..1653" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:18367543|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:30361468|PMID:18367543]" /experiment="EXISTENCE:mutant phenotype:GO:1990756 ubiquitin-like ligase-substrate adaptor activity [PMID:30361468]" /note="Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p" /db_xref="GeneID:855207" /db_xref="SGD:S000004781" ORIGIN 1 msfkfliesl llgsisgqir cgrssviprg dvsyggddtd elnmdimlfa fgtlivvyiv 61 icivyfftkq iatrlitayy nehgpgqris lfsdydenna hvhsrrlmen mslrwpnnld 121 dadevrdkla qlspeeqfyy kqgeeyikqn ppfllnqgll qqsedsnpdt tredpimneq 181 trqyiqeega yawefspnpd mpnhtviven ktevsflnyn ydasistnlp ipcinkvyyc 241 efkifetdgp lnsdenvskg visfglstqp ypyfrlpgrh hhsiaydsng arrfndsfkl 301 neqlrtlfpq cekgdivgig yrsrsgtvff trngkklnek svgghirgwk fqylypiigs 361 nvpcqihvnf gtygfvyiea nvkkwgyaks ngiklpppsy edygkdtlle sggedndfde 421 dfsdgdsdni aagsttnlnd diiirngeil ppppgfeftm spptgkkiin eeinldslpm 481 lppsysddeh hskndksais griigtsrnl itdeasfdsv dndnedendh erdpeqfsef 541 ddyesrmhgi // LOCUS NP_013895 719 aa linear PLN 30-JUN-2025 DEFINITION Hot1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013895 VERSION NP_013895.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182677.1 REFERENCE 1 (residues 1 to 719) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 719) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 719) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 719) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10068. Method: conceptual translation. FEATURES Location/Qualifiers source 1..719 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..719 /product="Hot1p" /calculated_mol_wt="79285" Region 242..>437 /region_name="ROM1" /note="RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]; COG5422" /db_xref="CDD:227709" Region 617..694 /region_name="GCR1_C" /note="Transcriptional activator of glycolytic enzymes; pfam12550" /db_xref="CDD:432628" CDS 1..719 /gene="HOT1" /locus_tag="YMR172W" /coded_by="NM_001182677.1:1..2160" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:11336700]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10409737]" /experiment="EXISTENCE:direct assay:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:12743037]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12743037]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10722658|PMID:10409737]" /experiment="EXISTENCE:genetic interaction:GO:0071470 cellular response to osmotic stress [PMID:10722658|PMID:10409737]" /experiment="EXISTENCE:mutant phenotype:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:12743037]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10409737|PMID:25904326|PMID:10722658]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12743037]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:10409737|PMID:10722658]" /note="Transcription factor for glycerol biosynthetic genes; required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p" /db_xref="GeneID:855208" /db_xref="SGD:S000004783" ORIGIN 1 msgmgiailc ivrtkiyrit isfdystlms pfflflmmpt tlkdgyrmns qvnedaigin 61 ldlslpthis pttgsesasg snastlrndg naldggllrt saaisaptgt sqptetigek 121 lsneervnsn vsasnsttag tgrmlsqslt ndspsneist dqlkifqrmd emsarmieme 181 esfnklsnki aeqntmvlnl kqdnykvmnk lnillklvaq psarpstnna qnklaielln 241 sisavssayl qkmqnngsgr qhtadlctgd snthsginqh rttngtidvn tntaqlnnqf 301 snalntilpd qqhnrnnvsq ninqslpnrq lgpvintqan qnqsqvlihn tnthqqvnrs 361 pisfpnastd kpfklnpngi krrrrntqsn nnastndhas aaqkpisals pltnshnstt 421 smnytnssih sgvtsasnsf hdlnslnnfg tttalslpsl aldnasfppn qnvippiinn 481 tqqplsfsql inqdsttsel lpsgksgvnt nivnrnrast lpsypkpmtv ksnvdddgyq 541 edddddgdde gdgrdneeds taeedevdde ietdmknasi nkrrrslhhk ksnslngrrk 601 lhgesatkpn insdlhyril kaptdvktiw eeydtgirgk psikhleaky gnkwrlnknk 661 ktfsrrkrly kfilngmerg ktaqemietl enkrlykdde dgevkkrtig wlqeslagi // LOCUS NP_013897 430 aa linear PLN 30-JUN-2025 DEFINITION DNA damage-responsive protein 48 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013897 VERSION NP_013897.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182678.1 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10069. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..430 /product="DNA damage-responsive protein 48" /calculated_mol_wt="46102" Region <80..>341 /region_name="ser_rich_anae_1" /note="serine-rich protein; NF033849" /db_xref="CDD:468206" Region 327..>393 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" CDS 1..430 /gene="DDR48" /locus_tag="YMR173W" /coded_by="NM_001182678.1:1..1293" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8444852]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:2111448]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:8444852]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:2111448]" /note="DNA damage-responsive protein; expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855210" /db_xref="SGD:S000004784" ORIGIN 1 mglfdkvkqf ansnnnnnds gnnnqgdyvt kaenmigedr vnqfkskige drfdkmeskv 61 rqqfsntsin dndsnnndsy gsnnndsygs nnndsygsnn ndsygsnnnd sygsnnddsy 121 gssnkkkssy gsnnddsygs snnndsygsn nndsygsnnn dsygsnndds ygssnknkss 181 ygsnnddsyg snnddsygss nkkkssygss nndsygsnnd dsygsnnnds ygsnnddsyg 241 ssnkkkssyg snnddsygss nnndsygsnn ddsygssnkn kssygsssnd dsygssnndd 301 sygssnkkks sygsnnddsy gsnnddsygs snkkkssygs snndsygsnn ddsygssnkk 361 kssygsnndd sygssnnnds ygsnnddsyg ssnrnknsyg ssnygssnnd dsygssnrgg 421 rnqyggdddy // LOCUS NP_013899 68 aa linear PLN 30-JUN-2025 DEFINITION Pai3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013899 VERSION NP_013899.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182680.1 REFERENCE 1 (residues 1 to 68) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 68) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 68) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 68) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10070. Method: conceptual translation. FEATURES Location/Qualifiers source 1..68 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..68 /product="Pai3p" /calculated_mol_wt="7576" Region 1..68 /region_name="Inhibitor_I34" /note="Saccharopepsin inhibitor I34; pfam10466" /db_xref="CDD:402202" CDS 1..68 /gene="PAI3" /locus_tag="YMR174C" /coded_by="NM_001182680.1:1..207" /experiment="EXISTENCE:direct assay:GO:0004866 endopeptidase inhibitor activity [PMID:17145748]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004866 endopeptidase inhibitor activity [PMID:2037077]" /experiment="EXISTENCE:mutant phenotype:GO:0007039 protein catabolic process in the vacuole [PMID:2037077]" /note="Cytoplasmic proteinase A (Pep4p) inhibitor; dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact" /db_xref="GeneID:855212" /db_xref="SGD:S000004786" ORIGIN 1 mntdqqkvse ifqsskeklq gdakvvsdaf kkmasqdkdg kttdadesek hnyqeqynkl 61 kgaghkke // LOCUS NP_013900 79 aa linear PLN 30-JUN-2025 DEFINITION Sip18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013900 VERSION NP_013900.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182681.1 REFERENCE 1 (residues 1 to 79) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 79) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 79) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 79) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 79) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10071. Method: conceptual translation. FEATURES Location/Qualifiers source 1..79 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..79 /product="Sip18p" /calculated_mol_wt="8743" CDS 1..79 /gene="SIP18" /locus_tag="YMR175W" /coded_by="NM_001182681.1:1..240" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:12082171]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22181064]" /experiment="EXISTENCE:mutant phenotype:GO:0042631 cellular response to water deprivation [PMID:21420397]" /note="Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress; SIP18 has a paralog, GRE1, that arose from the whole genome duplication" /db_xref="GeneID:855213" /db_xref="SGD:S000004787" ORIGIN 1 msnmmnkfae klqgnddshq kgknakssnk erddmnmdmg mghdqseggm kmghdqsgtk 61 mnagrgiand wktyenmkk // LOCUS NP_878143 64 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR175W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878143 VERSION NP_878143.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184660.1 REFERENCE 1 (residues 1 to 64) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 64) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 64) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 64) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10072. Method: conceptual translation. FEATURES Location/Qualifiers source 1..64 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..64 /product="uncharacterized protein" /calculated_mol_wt="7177" CDS 1..64 /locus_tag="YMR175W-A" /coded_by="NM_001184660.1:1..195" /note="hypothetical protein" /db_xref="GeneID:1466501" /db_xref="SGD:S000028848" ORIGIN 1 mnclclcsly sksisayfse fsstniyksy lrlpsvlyyv cmmhtmmpnq ldavgiqsse 61 sllm // LOCUS NP_013901 1411 aa linear PLN 30-JUN-2025 DEFINITION Ecm5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013901 VERSION NP_013901.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182682.1 REFERENCE 1 (residues 1 to 1411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1411) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10073. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1411 /product="Ecm5p" /calculated_mol_wt="162570" Region 187..280 /region_name="BRIGHT" /note="ARID (A/T-rich interaction domain) domain; smart00501" /db_xref="CDD:128777" Region 512..662 /region_name="cupin_RmlC-like" /note="RmlC-like cupin superfamily; cl40423" /db_xref="CDD:477354" Region 1240..1287 /region_name="PHD_Ecm5p_Lid2p_like" /note="PHD finger found in Saccharomyces cerevisiae extracellular matrix protein 5 (Ecm5p), Schizosaccharomyces pombe Lid2 complex component Lid2p, and similar proteins; cd15518" /db_xref="CDD:276993" Site order(1240,1250,1252..1255,1259,1282) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:276993" CDS 1..1411 /gene="ECM5" /locus_tag="YMR176W" /coded_by="NM_001182682.1:1..4236" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0070211 Snt2C complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:23878396]" /note="Subunit of the Snt2C complex; physically associates with Snt2p and Rpd3p; along with Snt2p, recruits Rpd3p to a small number of promoters; also colocalizes with Snt2p, independently of Rpd3p, to promoters of stress response genes in response to oxidative stress; contains ATP/GTP-binding site motif A; null mutant exhibits increased cellular volume, large drooping buds with elongated necks; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:855214" /db_xref="SGD:S000004788" ORIGIN 1 msghdsvtki shilnepvne kvmvqngfhe sskiadiele iqerpsikqw esprsavipt 61 snhnfspfly tqfksrgaap fapetiksvd lvelpegvpa rvfhektglf yqisphsipt 121 filakkelpd pikfyelved lgsvygcvkl kiipdadkft qlnvdvdrlw fkarkqffns 181 nefqrtkivd fyaklynfhn kikkstltri psidkrtldl yrlrscvklr ggfnavcekk 241 lwaqigrelg ysgrimssls tslrsayaki lldfdiyeee eqaarnnekn edmveseifr 301 hsnsrsrdee eplhkkakih rdvfragsin hefkrmrdik hikgfptyfn sltefklgyt 361 qstettlpgy dftfwengme iydkskyetk tspvynlrqy yekslavfta ivakfgssyp 421 dlfakhttlp qkeferlyfh llsehfidfe idtglglpcs mrspgnnssn ekfaiknild 481 qwnldnipln elsllqhldl dmanftrtty digmlfscqg wsvsdhflps idfnhlgstk 541 lvysiapkdm ekfealiarg ksewdtiqsr prystsddel ksfietdfyk sfldaeqsad 601 ysntgdnskn sfpedkiagn tlhdgsqsdf ifepnfilan giklykttqe qgsyifkfpk 661 aftcsigsgf ylsqnakfap sswlrfssea akwtskmgfl pgldvnqlli nallnsnnpv 721 lrkkcrdlis nyvveeaens kklgeligtv dvvynklnyi sdislestgl skivvthgal 781 qrnlslkefv vllekpenga hsicgipird qsgnlnvclh syfdsaslgi aldgldkppt 841 syllvhnedf ekkwdvlmts tfrnrtvpln iiqylishtd sntefnrmlr snfddsllli 901 ekckkfiktf vdvscsvkdv dfgngfnlrh lplkfsdnma dnleslyesv rkcsiefsek 961 ptiirlyhvs rqfpidnrdi idgnnldllk elyqksltip lkvsywtklt rkicrlewls 1021 vyehifierc diknedpaky slpllysyfe fglkycdsed idklgevrkl ilkyqdmmqk 1081 vrvflkkdpp skislsdled vlldieeyrl piqssffsel dyvireiena kkmndvnily 1141 ntdnidkide lirkndpkfv kfanqfngsr ldkrplasdn sgsvkakqel kvfklwnqhl 1201 dqimqknkfi eilpsifrcl dlksdkyipl escskrqtky cfcrrveegt amveceicke 1261 wyhvdcisng elvppddpnv lfvcsictpp cmavdniegv tfelddlkri lveslklsli 1321 pdppilknlf dvfafalnfk nemekelftn gyvnqlssth kikyylrklk gsqcgftnlt 1381 dplrkhcqvk daeaikwltd ngriiitgip n // LOCUS NP_013902 510 aa linear PLN 30-JUN-2025 DEFINITION Mmt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013902 VERSION NP_013902.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182683.1 REFERENCE 1 (residues 1 to 510) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 510) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 510) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 510) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10074. Method: conceptual translation. FEATURES Location/Qualifiers source 1..510 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..510 /product="Mmt1p" /calculated_mol_wt="56078" Region 160..479 /region_name="FieF" /note="Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism]; COG0053" /db_xref="CDD:439823" CDS 1..510 /gene="MMT1" /locus_tag="YMR177W" /gene_synonym="MFT1" /coded_by="NM_001182683.1:1..1533" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:9353309|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0006879 intracellular iron ion homeostasis [PMID:9353309]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9353309]" /note="Putative metal transporter involved in mitochondrial iron accumulation; MMT1 has a paralog, MMT2, that arose from the whole genome duplication" /db_xref="GeneID:855215" /db_xref="SGD:S000004789" ORIGIN 1 mlricvkrpc ikivlsqvrp allvrkenlh istgvkveks siinqkdpnk vrveinelkr 61 qaeiekaaik eleknpqyqk laeafnshdh vhlreseteq ndiislgtir dyksskceqa 121 dkpsslnlhs hthshghths haahnpllvl steqirknag vritwvglgv nvgiaigkff 181 ggivfhsqal fadaihaisd mvsdlltlls vglaankpta dypygygkie tvgslavsti 241 lamagisigw sslcalvgpv iphtiidtig nlghahtyse diiedvtdin aawiaaasia 301 akewifratr kiaintnsnv lmanawhhrv dsltslvalv aistgylvni qsldtiggli 361 vsgliikagg egmciaikel idqsvsrddp ryleietlvk dtlnklisnn nsqkpyglke 421 ltllssgpnl rghltlevpl qkwgnilgvn efeivthhlr nvltnevsnl rrldieyvee 481 kngeenehik gqqnykedvl ikhdhtnthi // LOCUS NP_013903 274 aa linear PLN 30-JUN-2025 DEFINITION flavin adenine dinucleotide pyrophosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013903 VERSION NP_013903.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182684.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10075. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..274 /product="flavin adenine dinucleotide pyrophosphatase" /calculated_mol_wt="31014" Region 5..175 /region_name="cinA" /note="Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; cd00885" /db_xref="CDD:238450" Site order(71..73,156..157,161,164) /site_type="active" /note="putative MPT binding site [active]" /db_xref="CDD:238450" CDS 1..274 /gene="FPY1" /locus_tag="YMR178W" /coded_by="NM_001182684.1:1..825" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0047884 FAD diphosphatase activity [PMID:29902190]" /experiment="EXISTENCE:genetic interaction:GO:0042726 flavin-containing compound metabolic process [PMID:29902190]" /note="FAD pyrophosphatase; hydrolyzes FAD as the preferred substrate but also acts on NADH and ADP-ribose at lower rates; activity is dependent upon K+ and divalent metal cations; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; FPY1 is not an essential gene; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855216" /db_xref="SGD:S000004790" ORIGIN 1 mvkvtaacii igdevlngkv vdtnstffak ycfdhgiqlk eiatigddet qivdtvrrlv 61 knydfiistg gigpthddit yecmaksfnl pceldeecke rmrhksdpea rldadalkah 121 yqmatmpkgt nvknyyvcdd lwvpicsish kmyilpgipq lfarmlkaft ptlkkiynld 181 kdpreyvryf vrthltesqi skelkliqde stkvseaiki gsyphfgmgf ntvsilgekk 241 ddsylksivn rvvnnlegev isselenkfs nqes // LOCUS NP_013904 758 aa linear PLN 30-JUN-2025 DEFINITION Spt21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013904 VERSION NP_013904.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182685.1 REFERENCE 1 (residues 1 to 758) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 758) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 758) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 758) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10076. Method: conceptual translation. FEATURES Location/Qualifiers source 1..758 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..758 /product="Spt21p" /calculated_mol_wt="84566" CDS 1..758 /gene="SPT21" /locus_tag="YMR179W" /coded_by="NM_001182685.1:1..2277" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:21057056]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:21057056]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:8035801]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:21057056]" /note="Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; binds with Spt10p to histone gene promoters during S phase; localizes to nuclear foci that become diffuse upon DNA replication stress" /db_xref="GeneID:855217" /db_xref="SGD:S000004791" ORIGIN 1 mselsqmtlk ilytldngsn gsylarsrap kqvrvanips pfptdsneqt elrigaihlk 61 tilheiylns pevldhdtlk dgydynlyyr dicevdeplv slgllsglrk kfhknspyqy 121 tennigeees eerdevteee yedesfivtg rvcsnvsall rrsysnisnk kgrvvnnqip 181 eetlevklrf tkvitnlrts gnnttnsris clqmpsslps atlpftpksq slfktnqikn 241 srnarttiti nntnsgtvgr rqtnpmpapk avrtqslpiw nlkpniantg fprnsiahki 301 yladrktean qqnnqhqnia yeintlqndn tiqrtkidds vskrfdfmln krkstkkvsp 361 giatiakkpa sininpkqpp ktsgekkand kqtivkvkns nsknsakstq agcrrssvie 421 hlndhddsil sdilsepgie gqklqqkqkg rkisltsend kenippqsit skenklegdl 481 dfnaefpmsd fsdvvfkdem gwfsnfncnf fesptsasas qlnqqnlkps itlndpntcn 541 tialenedvs eletaqnnki slpsdvdkts pidslsipli elthsssttn mqrisikegs 601 tlnitdsnna tpcdndikdr kasvidsdnt kpqaglinfs tpadqpasdn nvtaskklts 661 mletqqskrs heevldeeee eealkkqkai psspcgmfny hqpmelsedi veeeqghnig 721 ddnesdktnd lfstfihsgi rvsqvvtspi gefqsikh // LOCUS NP_013905 320 aa linear PLN 30-JUN-2025 DEFINITION polynucleotide 5'-phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013905 VERSION NP_013905.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182686.1 REFERENCE 1 (residues 1 to 320) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 320) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 320) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 320) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10077. Method: conceptual translation. FEATURES Location/Qualifiers source 1..320 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..320 /product="polynucleotide 5'-phosphatase" /EC_number="3.6.1.74" /calculated_mol_wt="36843" Region 61..278 /region_name="mRNA_triPase" /note="mRNA capping enzyme, beta chain; pfam02940" /db_xref="CDD:397201" Site order(65..66,135,139,246,254,300,303..304,306..307) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:143621" Site order(87,89,160,178,191,195,219,237,239,241,255,273,275, 277) /site_type="active" /db_xref="CDD:143621" Site order(87,89,255,275,277) /site_type="other" /note="putative metal binding residues [ion binding]" /db_xref="CDD:143621" Site order(87,160,178,191,195,219,239,241,277) /site_type="other" /note="gamma-phosphate binding site [chemical binding]" /db_xref="CDD:143621" Site order(87,89,91) /site_type="active" /note="signature motif [active]" /db_xref="CDD:143621" Site 237..239 /site_type="other" /note="motif B" /db_xref="CDD:143621" Site 273..277 /site_type="other" /note="motif C" /db_xref="CDD:143621" CDS 1..320 /gene="CTL1" /locus_tag="YMR180C" /gene_synonym="CTH1" /coded_by="NM_001182686.1:1..963" /experiment="EXISTENCE:direct assay:GO:0004651 polynucleotide 5'-phosphatase activity [PMID:10219091]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10219091]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10219091]" /note="RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm; CTL1 has a paralog, CET1, that arose from the whole genome duplication" /db_xref="GeneID:855218" /db_xref="SGD:S000004792" ORIGIN 1 msdqpetpsn srnshenvga kkadanvask frslhisett kpltstraly kttrnnsrga 61 tefhkhvckl awkylacidk ssishieiem kfgvitdkrt hrrmtphnkp fivqnrngrl 121 vsnvpeqmfs sfqellrsks enpskcaprv vkqvqkytkd siyncnnask vgkltswrcs 181 edlrnkelkl tyikkvrvkd flirypqssl dakisislev peyetsaafr ngfilqrtks 241 rstytfndkm plhldltkvt ttrrnshqyt shevevemdp ifketisand rekfneymcs 301 flnasdlirk aaerdnmltt // LOCUS NP_013906 154 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR181C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013906 VERSION NP_013906.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182687.1 REFERENCE 1 (residues 1 to 154) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 154) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 154) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 154) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 154) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10078. Method: conceptual translation. FEATURES Location/Qualifiers source 1..154 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..154 /product="uncharacterized protein" /calculated_mol_wt="17471" CDS 1..154 /locus_tag="YMR181C" /coded_by="NM_001182687.1:1..465" /note="hypothetical protein; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); not an essential gene; YMR181C has a paralog, YPL229W, that arose from the whole genome duplication" /db_xref="GeneID:855219" /db_xref="SGD:S000004793" ORIGIN 1 mtpllqaeak mntslyltes iqqhefnlts pqsfysspsv pnsknnsgif syntannsrv 61 sssdefttqq dgmntimykn nisktfeddi fycprslltp eeqvvyqeid kyymeqallt 121 qlqisqtyss tpkeekivkf npytsksfsp asse // LOCUS NP_013907 211 aa linear PLN 30-JUN-2025 DEFINITION Rgm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013907 VERSION NP_013907.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182688.1 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10079. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..211 /product="Rgm1p" /calculated_mol_wt="23724" Region 19..44 /region_name="zf-C2H2" /note="Zinc finger, C2H2 type; pfam00096" /db_xref="CDD:395048" Region 21..44 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 36..61 /region_name="zf-H2C2_2" /note="Zinc-finger double domain; pfam13465" /db_xref="CDD:463886" Region 52..69 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..211 /gene="RGM1" /locus_tag="YMR182C" /coded_by="NM_001182688.1:1..636" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:19372386|PMID:21206489]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16880382|PMID:1923755]" /note="Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y' telomeric elements and subtelomeric COS genes; relocalizes to the cytosol in response to hypoxia; RGM1 has a paralog, USV1, that arose from the whole genome duplication" /db_xref="GeneID:855220" /db_xref="SGD:S000004794" ORIGIN 1 mrgkqpkrnk dnasvkrnyr cvgypdcnms fnrtehlarh irkhtgekpf qcniclkffs 61 ridnlrqhqs svhsdvdlms lrrlqqsans tandpnatrm fpqlrpygiv vqpapvpynl 121 pistpaspqd tislyappyf phpmpsapip lphqppplpi ysymqplfln htpiqnhniv 181 elppdssdtp aspskvqsfd qakdaspnak k // LOCUS NP_878144 28 aa linear PLN 30-JUN-2025 DEFINITION Min3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878144 VERSION NP_878144.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184615.1 REFERENCE 1 (residues 1 to 28) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 28) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 28) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 28) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 28) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10080. Method: conceptual translation. FEATURES Location/Qualifiers source 1..28 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..28 /product="Min3p" /calculated_mol_wt="2960" CDS 1..28 /gene="MIN3" /locus_tag="YMR182W-A" /coded_by="NM_001184615.1:1..87" /note="Mitochondrial hypothetical protein" /db_xref="GeneID:1466502" /db_xref="SGD:S000028693" ORIGIN 1 mrkpsafhac niiflplvkc asatimln // LOCUS NP_013908 295 aa linear PLN 30-JUN-2025 DEFINITION syntaxin [Saccharomyces cerevisiae S288C]. ACCESSION NP_013908 VERSION NP_013908.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182689.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10081. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..295 /product="syntaxin" /calculated_mol_wt="33603" Region 1..280 /region_name="COG5074" /note="t-SNARE complex subunit, syntaxin [Intracellular trafficking, secretion, and vesicular transport]" /db_xref="CDD:227406" CDS 1..295 /gene="SSO2" /locus_tag="YMR183C" /coded_by="NM_001182689.1:1..888" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:19502581]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19502581|PMID:17507646|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:19502581]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0031321 ascospore-type prospore assembly [PMID:19502581]" /experiment="EXISTENCE:physical interaction:GO:0005484 SNAP receptor activity [PMID:7954793]" /note="Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog, SSO1, that arose from the whole genome duplication" /db_xref="GeneID:855221" /db_xref="SGD:S000004795" ORIGIN 1 msnanpyenn npyaenyemq edlnnaptgh sdgsddfvaf mnkinsinan lsryeniinq 61 idaqhkdllt qvseeqemel rrslddyisq atdlqyqlka dikdaqrdgl hdsnkqaqae 121 ncrqkflkli qdyriidsny keeskeqakr qytiiqpeat deeveaaind vngqqifsqa 181 llnanrrgea ktalaevqar hqellklekt maeltqlfnd meelvieqqe nvdvidknve 241 daqqdveqgv ghtnkavksa rkarknkirc liicfiifai vvvvvvvpsv vetrk // LOCUS NP_013909 198 aa linear PLN 30-JUN-2025 DEFINITION Add37p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013909 VERSION NP_013909.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182690.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10082. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..198 /product="Add37p" /calculated_mol_wt="21978" CDS 1..198 /gene="ADD37" /locus_tag="YMR184W" /coded_by="NM_001182690.1:1..597" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:12711700]" /note="hypothetical protein; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855222" /db_xref="SGD:S000004796" ORIGIN 1 maikptksfq ncleaevpgy ndcptvlfsi dpnsgprsks kqrtkskrcv sgrlatevld 61 lygntktatt pppvlrrpsv taaqqesace gvlvkdqgdr qlqpilcske elvakindlc 121 vcgsklsske lefykkklds nitkilqneh tktvlsqifn ekdknmavkt ikhwmvtdtt 181 isnwcpaflk ifenampn // LOCUS NP_013910 981 aa linear PLN 30-JUN-2025 DEFINITION Rtp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013910 VERSION NP_013910.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182691.1 REFERENCE 1 (residues 1 to 981) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 981) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 981) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 981) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 981) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 981) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 981) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10083. Method: conceptual translation. FEATURES Location/Qualifiers source 1..981 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..981 /product="Rtp1p" /calculated_mol_wt="113118" Region 732..841 /region_name="RTP1_C1" /note="Required for nuclear transport of RNA pol II C-terminus 1; pfam10363" /db_xref="CDD:463059" Region 947..979 /region_name="RTP1_C2" /note="Required for nuclear transport of RNA pol II C-terminus 2; pfam10304" /db_xref="CDD:431206" CDS 1..981 /gene="RTP1" /locus_tag="YMR185W" /coded_by="NM_001182691.1:1..2946" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23438601]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:23438601]" /note="Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene" /db_xref="GeneID:855223" /db_xref="SGD:S000004797" ORIGIN 1 mnedkeqkin ihdilntrpk ltkktaldvf fedlddnvit pineyvldsg ssssssiyqa 61 lkcsnnnefv avllqkfqnl hihvleqqrr liesksdllp islhdmkyvd elinlliihg 121 idanlsptmk ipfdskrint fkkgqksaey etprwhtinn dtlsqvitvf ynvltserss 181 dylreiiskg sayanillgl ivlhlqlpnr yssqmitnle dtqetytlfg vytllvetiq 241 dekvrepils klttltlrrp englislidf vlgvrdaedi diekfnriyq ilmskpktmt 301 nlqyltelfk qiydgltfvn rpilvtclng lilkfylrnk rivndflfkk vrsiifnspl 361 tdhtakelnd vinvlislsk nsssdllndl vtscpdedgt tpgqfflyvw iyalflkknq 421 kldpleinkl sisdnkstds ihfpeqsssk yyevvlsllk slivitenfq ylnvlslnll 481 nfehekwkyl idldtqlpyi svkntdmael ffekgsknsq iseflqdmdl sielfmeflv 541 llndeeqskt lfldilkrwv hhtkksekrs sdnhsgmpsv tdnalilmdl kllecmnnrf 601 ktkivnkpkd vlividqlid vvqekdetiq eveadsddev eegeeteeld pnenssykii 661 lqllstvlse ssssillqns yilksisrkl qsfntnasei dallasidni linghttern 721 dnieiemdee rldkaitslh dplvpiksyg ltelrhlaek kspvislekv lqihldylkn 781 mdpfiylnvi kglttlcele petilpllae fyankkkknr lddvlkvgev finyiqrqne 841 lfqgklayli idtclsivrp ndskpldnrw rmssmsilgm clqinargvs drirdmldcv 901 fgilqleqpq nhlkdkddsf lmrrsavhli hdllystgfd llpfeynydk lktllsyvrd 961 qdedymvceq idklltvlds l // LOCUS NP_013911 705 aa linear PLN 30-JUN-2025 DEFINITION Hsp90 family chaperone HSC82 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013911 VERSION NP_013911.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182692.1 REFERENCE 1 (residues 1 to 705) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 705) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 705) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 705) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 705) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10084. Method: conceptual translation. FEATURES Location/Qualifiers source 1..705 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..705 /product="Hsp90 family chaperone HSC82" /calculated_mol_wt="80769" Region 4..705 /region_name="HSP90" /note="Hsp90 protein; cl46693" /db_xref="CDD:481033" CDS 1..705 /gene="HSC82" /locus_tag="YMR186W" /gene_synonym="HSP90" /coded_by="NM_001182692.1:1..2118" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:18492664]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9465043]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:18268103]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:17954556]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:7791797]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:2674684]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:12853471]" /note="Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication" /db_xref="GeneID:855224" /db_xref="SGD:S000004798" ORIGIN 1 magetfefqa eitqlmslii ntvysnkeif lrelisnasd aldkiryqal sdpkqletep 61 dlfiritpkp eekvleirds gigmtkaeli nnlgtiaksg tkafmealsa gadvsmigqf 121 gvgfyslflv adrvqviskn nedeqyiwes naggsftvtl devnerigrg tvlrlflkdd 181 qleyleekri kevikrhsef vaypiqllvt kevekevpip eeekkdeekk deddkkpkle 241 evdeeeeekk pktkkvkeev qeleelnktk plwtrnpsdi tqeeynafyk sisndwedpl 301 yvkhfsvegq lefrailfip krapfdlfes kkkknnikly vrrvfitdea edlipewlsf 361 vkgvvdsedl plnlsremlq qnkimkvirk nivkklieaf neiaedseqf dkfysafakn 421 iklgvhedtq nraalakllr ynstksvdel tsltdyvtrm pehqkniyyi tgeslkavek 481 spfldalkak nfevlfltdp ideyaftqlk efegktlvdi tkdfeleetd eekaerekei 541 keyepltkal kdilgdqvek vvvsykllda paairtgqfg wsanmerimk aqalrdssms 601 symsskktfe ispkspiike lkkrvdegga qdktvkdltn llfetallts gfsleeptsf 661 asrinrlisl glnidedeet etapeastea pveevpadte meevd // LOCUS NP_013912 431 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR187C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013912 VERSION NP_013912.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182693.1 REFERENCE 1 (residues 1 to 431) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 431) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 431) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 431) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 431) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10085. Method: conceptual translation. FEATURES Location/Qualifiers source 1..431 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..431 /product="uncharacterized protein" /calculated_mol_wt="50157" CDS 1..431 /locus_tag="YMR187C" /coded_by="NM_001182693.1:1..1296" /note="hypothetical protein; YMR187C is not an essential gene" /db_xref="GeneID:855225" /db_xref="SGD:S000004799" ORIGIN 1 mtpphfflsl ikkrcicwic leestydstw lqhtcgcnlq ihkrcyirwl yqmhvelflp 61 ntvdlpkdad lpiitclkcl vdghhdfmtt fslteiwetr piwgqksvpf qndyvfnlms 121 lytkrdnhpp yvlvkfgecp qckktnfikr ptvtiqssvl slfyqwqkit ryviplgits 181 lfllnpekts fdiglwqlrc lfpenvlrnm lnisttkald vyaqtergll sipltssiii 241 ygfihylsni snvsanailf kwvylsivkt agnkyykgig lpkiilysnl atfcynftfk 301 rlvdliyrrl inkggkylyh gnfenssnsv paeeffirrn wyailaekil wpfvgkctgg 361 lllnaflwiq rkfkiewtpn cspsefrmif niigcgtaai gwsslklyas ykrcqeleki 421 nefieqsckg e // LOCUS NP_013913 237 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS17m MRPS17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013913 VERSION NP_013913.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182694.1 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10086. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..237 /product="mitochondrial 37S ribosomal protein uS17m MRPS17" /calculated_mol_wt="27504" Region 8..76 /region_name="Ribosomal_S17" /note="Ribosomal protein S17; pfam00366" /db_xref="CDD:459784" CDS 1..237 /gene="MRPS17" /locus_tag="YMR188C" /gene_synonym="uS17m" /coded_by="NM_001182694.1:1..714" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24390141|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:855226" /db_xref="SGD:S000004800" ORIGIN 1 marqnflglv vsqgkmqktv kvrvetkvfn kkinkelfhr rdylvhdege isregdlvri 61 eatrplskrk ffaiaeiirn kgqqfalyes eaqlsvakee aqkakefldk rsvrenklne 121 kttllrdirt iqdalssgst pkelleikqr ygiqdfsqet vrqllqldis glevnlekqr 181 slidriqtrl sellsndlkc dqflkdhgve dpltlkknik knllrkhvmm dmqqpsq // LOCUS NP_013914 1034 aa linear PLN 30-JUN-2025 DEFINITION glycine decarboxylase subunit P [Saccharomyces cerevisiae S288C]. ACCESSION NP_013914 VERSION NP_013914.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182695.1 REFERENCE 1 (residues 1 to 1034) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1034) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1034) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1034) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1034) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1034) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1034) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10087. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1034 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1034 /product="glycine decarboxylase subunit P" /EC_number="1.4.4.2" /calculated_mol_wt="114321" Region 70..1023 /region_name="gcvP" /note="glycine dehydrogenase (decarboxylating); TIGR00461" /db_xref="CDD:273089" CDS 1..1034 /gene="GCV2" /locus_tag="YMR189W" /gene_synonym="GSD2" /coded_by="NM_001182695.1:1..3105" /experiment="EXISTENCE:direct assay:GO:0004375 glycine dehydrogenase (decarboxylating) activity [PMID:320197|PMID:8830251]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:genetic interaction:GO:0006730 one-carbon metabolic process [PMID:10871621]" /experiment="EXISTENCE:mutant phenotype:GO:0019464 glycine decarboxylation via glycine cleavage system [PMID:8830251]" /note="P subunit of the mitochondrial glycine decarboxylase complex; glycine decarboxylase is required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm" /db_xref="GeneID:855227" /db_xref="SGD:S000004801" ORIGIN 1 mlrtrvtall cratvrsstn yvslartrsf hsqsillkta atditstqys rifnpdlkni 61 drpldtfarr hlgpspsdvk kmlktmgysd lnafieelvp pnilkrrplk leapskgfce 121 qemlqhleki anknhykvkn figkgyygti lppviqrnll espewytsyt pyqpeisqgr 181 leallnfqtv vsdltglpva naslldegta ageamllsfn isrkkklkyv idkklhqqtk 241 svlhtrakpf nieiievdcs dikkavdvlk npdvsgclvq ypatdgsilp pdsmkqlsda 301 lhshksllsv asdlmaltll kppahygadi vlgssqrfgv pmgyggphaa ffavidklnr 361 kipgrivgis kdrlgktalr lalqtreqhi krdkatsnic taqallanva ssycvyhgpk 421 glqnisrrif sltsilanai endscpheli nktwfdtlti klgngisseq lldkalkefn 481 inlfavdttt islaldettt kadvenllkv fdienssqfl sedysnsfpr efqrtdeilr 541 nevfhmhhse tamlrylhrl qsrdlslans miplgsctmk lnstvemmpi twpqfsnihp 601 fqpsnqvqgy kelitslekd lcsitgfdgi slqpnsgaqg eytglrvirs yleskgenhr 661 nvclipvsah gtnpasaama glkvvpvncl qdgsldlvdl knkaeqhske laavmityps 721 tyglfepgiq haidivhsfg gqvyldganm naqvgltspg dlgadvchln lhktfsiphg 781 gggpagapic vkshliphlp khdvvdmitg iggsksidsv ssapygnalv lpisyayikm 841 mgneglpfss viamlnsnym mtrlkdhyki lfvnemstlk hcahefivdl reykakgvea 901 idvakrlqdy gfhaptlafp vpgtlmiept esenleeldr fcdamisike einalvagqp 961 kgqilknaph sledlitssn wdtrgytree aayplpflry nkfwptvarl ddtygdmnli 1021 ctcpsveeia nete // LOCUS NP_013915 1447 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent DNA helicase SGS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013915 VERSION NP_013915.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182696.1 REFERENCE 1 (residues 1 to 1447) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1447) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1447) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1447) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10088. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1447 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1447 /product="ATP-dependent DNA helicase SGS1" /EC_number="5.6.2.4" /calculated_mol_wt="163707" Region 670..1151 /region_name="RecQ" /note="Superfamily II DNA helicase RecQ [Replication, recombination and repair]; COG0514" /db_xref="CDD:440280" Region 1271..1350 /region_name="Helicase_Sgs1" /note="Sgs1 RecQ helicase; pfam11408" /db_xref="CDD:463270" CDS 1..1447 /gene="SGS1" /locus_tag="YMR190C" /coded_by="NM_001182696.1:1..4344" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:9545297]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9271578]" /experiment="EXISTENCE:direct assay:GO:0006260 DNA replication [PMID:10366502]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]" /experiment="EXISTENCE:direct assay:GO:0031422 RecQ family helicase-topoisomerase III complex [PMID:25588990|PMID:15899853]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:9545297]" /experiment="EXISTENCE:genetic interaction:GO:0000706 meiotic DNA double-strand break processing [PMID:20150422]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:16546998|PMID:17550308]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:19595717]" /experiment="EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:19158388]" /experiment="EXISTENCE:genetic interaction:GO:0000729 DNA double-strand break processing [PMID:18806779]" /experiment="EXISTENCE:genetic interaction:GO:0007534 gene conversion at mating-type locus [PMID:18806779]" /experiment="EXISTENCE:genetic interaction:GO:0010520 regulation of reciprocal meiotic recombination [PMID:18691965]" /experiment="EXISTENCE:genetic interaction:GO:0010947 negative regulation of meiotic joint molecule formation [PMID:18691964]" /experiment="EXISTENCE:genetic interaction:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:19158388]" /experiment="EXISTENCE:genetic interaction:GO:0031860 telomeric 3' overhang formation [PMID:19595717|PMID:20808892]" /experiment="EXISTENCE:genetic interaction:GO:0044818 mitotic G2/M transition checkpoint [PMID:18805091]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:7736577]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:15994923|PMID:17550308]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:19158388]" /experiment="EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:18805091]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:19158388]" /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:7736577]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:11138010]" /experiment="EXISTENCE:physical interaction:GO:0031422 RecQ family helicase-topoisomerase III complex [PMID:15889139]" /note="RecQ family nucleolar DNA helicase; role in genome integrity maintenance, chromosome synapsis, meiotic joint molecule/crossover formation; stimulates activity of Top3p; rapidly lost in response to rapamycin in Rrd1p-dependent manner; forms nuclear foci upon DNA replication stress; yeast SGS1 complements mutations in human homolog BLM implicated in Bloom syndrome; also similar to human WRN implicated in Werner syndrome; human BLM and WRN can each complement yeast null mutant" /db_xref="GeneID:855228" /db_xref="SGD:S000004802" ORIGIN 1 mvtkpshnlr rehkwlketa tlqedkdfvf qaiqkhiank rpktnspptt pskdecgpgt 61 tnfitsipas gptntatkqh evmqtlsndt ewlsytatsn qyadvpmvdi pastsvvsnp 121 rtpngskthn fntfrphmas slvendssrn lgsrnnnksv idnssigkql endiklevir 181 lqgslimalk eqsklllqkc siiestslse dakrlqlsrd irpqlsnmsi ridslekeii 241 kakkdgmskd qskgrsqvss qddniissil pspleyntss rnsnltstta ttvtkalait 301 gakqnitnnt gknsnndsnn ddliqvldde ddidcdppvi lkegaphspa fphlhmtsee 361 qdeltrrrnm rsrepvnyri pdrddpfdyv mgkslrddyp dvereedelt meaeddahss 421 ymttrdeeke enellnqsdf dfvvnddldp tqdtdyhdnm dvsaniqess qegdtrstit 481 lsqnknvqvi lssptaqsvp sngqnqigve hidlleddle kdailddsms fsfgrqhmpm 541 shsdlelids ekenedfeed nnnngieyls dsdlerfdee renrtqvadi qeldndlkii 601 terkltgdne hpppswspki krekssvsqk deeddfdddf slsdivsksn lssktngpty 661 pwsdevlyrl hevfklpgfr pnqleavnat lqgkdvfvlm ptgggkslcy qlpavvksgk 721 thgttivisp lislmqdqve hllnknikas mfssrgtaeq rrqtfnlfin glldlvyisp 781 emisaseqck raisrlyadg klarivvdea hcvsnwghdf rpdykelkff kreypdipmi 841 altataseqv rmdiihnlel kepvflkqsf nrtnlyyevn kktkntifei cdavksrfkn 901 qtgiiychsk ksceqtsaqm qrngikcayy hagmepderl svqkawqade iqvicatvaf 961 gmgidkpdvr fvyhftvprt legyyqetgr agrdgnysyc ityfsfrdir tmqtmiqkdk 1021 nldrenkekh lnklqqvmay cdnvtdcrrk lvlsyfnedf dsklchkncd ncrnsanvin 1081 eerdvtepak kivklvesiq nervtiiycq dvfkgsrssk ivqanhdtle ehgigksmqk 1141 seieriffhl itirvlqeys imnnsgfass yvkvgpnakk lltgkmeikm qftisapnsr 1201 pstsssfqan ednipviaqk sttiggnvaa npprfisake hlrsytyggs tmgsshpitl 1261 kntsdlrstq elnnlrmtye rlrelslnlg nrmvppvgnf mpdsilkkma ailpmndsaf 1321 atlgtvedky rrrfkyfkat iadlskkrss edhekydtil ndefvnraaa ssngiaqstg 1381 tkskffganl neakeneqii nqirqsqlpk nttssksgtr sisksskksa ngrrgfrnyr 1441 ghyrgrk // LOCUS NP_013916 373 aa linear PLN 30-JUN-2025 DEFINITION Spg5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013916 VERSION NP_013916.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182697.1 REFERENCE 1 (residues 1 to 373) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 373) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 373) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 373) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10089. On Oct 2, 2003 this sequence version replaced NP_013916.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..373 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..373 /product="Spg5p" /calculated_mol_wt="42032" CDS 1..373 /gene="SPG5" /locus_tag="YMR191W" /coded_by="NM_001182697.1:1..1122" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:22904326]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:22904326]" /note="Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources" /db_xref="GeneID:855229" /db_xref="SGD:S000004803" ORIGIN 1 mavggnnwsm wlrmsrvhlr qitksldrtl islshgnfsh qynrnifvtw wkslfeasta 61 frrasgltvs pltrrgiarf dhfrpvpnvs kfasfprvpk gaprglftnw nmttskrllg 121 qraystssik ftqeavnnmt islrcffnsl gglnqcshsn sckayqnasn vtskqdhvqp 181 valkklsqkd infirnlelf kimktqnevv detsayymek pgsyieftis efnvngtfsa 241 plsfldpsll adldemirny kyelksiyss vdmilqnygs lpitfhrnki rihfpnstvv 301 etekliagln iatgviyadt spdislegtn lnalvnvdns gsvwsfvkep sfpsrsafsp 361 ilsdasydty elv // LOCUS NP_013917 720 aa linear PLN 30-JUN-2025 DEFINITION Gyl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013917 VERSION NP_013917.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182698.1 REFERENCE 1 (residues 1 to 720) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 720) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 720) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 720) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10090. Method: conceptual translation. FEATURES Location/Qualifiers source 1..720 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..720 /product="Gyl1p" /calculated_mol_wt="82001" Region 27..569 /region_name="COG5210" /note="GTPase-activating protein [General function prediction only]" /db_xref="CDD:227535" CDS 1..720 /gene="GYL1" /locus_tag="YMR192W" /gene_synonym="APP2" /coded_by="NM_001182698.1:1..2163" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005798 Golgi-associated vesicle [PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15331637|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15331637|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:15802519]" /experiment="EXISTENCE:genetic interaction:GO:0017157 regulation of exocytosis [PMID:15331637]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10992286|PMID:15802519|PMID:12857883]" /experiment="EXISTENCE:physical interaction:GO:0017157 regulation of exocytosis [PMID:15331637]" /note="Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress; GYL1 has a paralog, GYP5, that arose from the whole genome duplication" /db_xref="GeneID:855230" /db_xref="SGD:S000004804" ORIGIN 1 mnsnedihee rievprtphq tqpekdsdri alrdeisvpe gdekaysdek vemattnass 61 nfgsnesakd gesigafsnp healmqsklr eesqsktilp sddlsqqlet eeskveealk 121 ritspplppr adcieesasa lksslppvla gnkndqapld rpqlpprqvv naetlhlkap 181 hgnatpsksp tsavgnssss tpptlpprri edpldlaaqk hflastfkrn mlfyksedns 241 ikcdldknil nlkedskkin nneipeevss fwlkvigdyq nilindietl hfqlsrgipa 301 ayrlvvwqlv syaksksfdp iyetyltema pfdvqefenq lkmmdevpse yvkrisnvlk 361 ayllfdpece fstdiayiin mildvceeea nafgllvrlm kvyglrllfl psaseidilc 421 ykfdrlveef ypeihnhmve kgvrssmflp gffttlfqkk lpteiqprig dmvflegids 481 imrilatlls nsrdhllkmg fddmlellks glldayikqn dgtrgdtlls necmdkllqd 541 smmkvaitpk tmkkysseye eihrldneke vqyksitekn lhlqkhvrkl endytslnre 601 hvtianelvk nrlniesvln enngyklqil dlkkkldsek kkqvlgvyvp ndlkkdleet 661 mkkntqvmde nlklqdrise lerlieeikt ankngtlfey snsknnplga gwsgfkkvfk // LOCUS NP_013918 258 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL28m MRPL24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013918 VERSION NP_013918.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182700.1 REFERENCE 1 (residues 1 to 258) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 258) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 258) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 258) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10091. Method: conceptual translation. FEATURES Location/Qualifiers source 1..258 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..258 /product="mitochondrial 54S ribosomal protein bL28m MRPL24" /calculated_mol_wt="29918" Region 71..126 /region_name="Ribosomal_L28" /note="Ribosomal L28 family; pfam00830" /db_xref="CDD:459953" CDS 1..258 /gene="MRPL24" /locus_tag="YMR193W" /gene_synonym="bL28m" /coded_by="NM_001182700.1:1..777" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene" /db_xref="GeneID:855231" /db_xref="SGD:S000004806" ORIGIN 1 mqkifrpfql trgftssvkn frqwrlietr kiakqpnyqv gdakplhmpk erkkfpdyky 61 gesnifkqsn kglyggsfvq fgnniseska ktrkkwlpnv vkkglwsetl nrkisikmta 121 kvlktiskeg gidnyltkek sarikelgpt gwklryrvlk rkdeienpph kdapiiemag 181 gkkakiyyde ivngsprkis vgrrrlmsfl yplekleyrs vgkdlnykkf velfadvpvk 241 dilarledhk fdlstitv // LOCUS NP_013920 100 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL36 RPL36A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013920 VERSION NP_013920.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182701.1 REFERENCE 1 (residues 1 to 100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 100) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10092. Method: conceptual translation. FEATURES Location/Qualifiers source 1..100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..100 /product="60S ribosomal protein eL36 RPL36A" /calculated_mol_wt="10993" Region 4..99 /region_name="Ribosomal_L36e" /note="Ribosomal protein L36e; pfam01158" /db_xref="CDD:460088" CDS 1..100 /gene="RPL36A" /locus_tag="YMR194W" /gene_synonym="RPL39B" /coded_by="NM_001182701.1:1..303" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L36A; N-terminally acetylated; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36A has a paralog, RPL36B, that arose from the whole genome duplication" /db_xref="GeneID:855232" /db_xref="SGD:S000004807" ORIGIN 1 mtvktgiaig lnkgkkvtsm tpapkisykk gaasnrtkfv rslvreiagl spyerrlidl 61 irnsgekrar kvakkrlgsf trakakveem nniiaasrrh // LOCUS NP_878145 73 aa linear PLN 30-JUN-2025 DEFINITION Cmc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878145 VERSION NP_878145.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184524.1 REFERENCE 1 (residues 1 to 73) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 73) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 73) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 73) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10093. Method: conceptual translation. FEATURES Location/Qualifiers source 1..73 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..73 /product="Cmc4p" /calculated_mol_wt="8071" Region 4..61 /region_name="MTCP1" /note="Mature-T-Cell Proliferation I type; pfam08991" /db_xref="CDD:430360" CDS 1..73 /gene="CMC4" /locus_tag="YMR194C-B" /coded_by="NM_001184524.1:1..222" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:19703468]" /note="Protein that localizes to the mitochondrial intermembrane space; localizes via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs" /db_xref="GeneID:1466503" /db_xref="SGD:S000028514" ORIGIN 1 msnpcqkeac aiqdcllshq yddakcakvi dqlyiccskf yndngkdsrs pccplpslle 61 lkmkqrkltp gds // LOCUS NP_013922 127 aa linear PLN 30-JUN-2025 DEFINITION Icy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013922 VERSION NP_013922.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182702.1 REFERENCE 1 (residues 1 to 127) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 127) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 127) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 127) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 127) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10094. Method: conceptual translation. FEATURES Location/Qualifiers source 1..127 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..127 /product="Icy1p" /calculated_mol_wt="14205" CDS 1..127 /gene="ICY1" /locus_tag="YMR195W" /coded_by="NM_001182702.1:1..384" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095]" /note="hypothetical protein; required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation; ICY1 has a paralog, ATG41, that arose from the whole genome duplication" /db_xref="GeneID:855235" /db_xref="SGD:S000004808" ORIGIN 1 mssnyatpld devfplsfan yqftehvslg ehyslntsed akynnlngpf vvprdtgkfd 61 lntssasdet vfsldnpqen nykhqamnnv qdcrmavaak ttqscdkltd lyanaaqqny 121 rlwlssf // LOCUS NP_013923 1088 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR196W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013923 VERSION NP_013923.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182703.1 REFERENCE 1 (residues 1 to 1088) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1088) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1088) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1088) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1088) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1088) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1088) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10095. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1088 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1088 /product="uncharacterized protein" /calculated_mol_wt="126494" Region 475..934 /region_name="GDB1" /note="Glycogen debranching enzyme (alpha-1,6-glucosidase) [Carbohydrate transport and metabolism]; COG3408" /db_xref="CDD:442634" CDS 1..1088 /locus_tag="YMR196W" /coded_by="NM_001182703.1:1..3267" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141|PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene" /db_xref="GeneID:855236" /db_xref="SGD:S000004809" ORIGIN 1 mnklrdkfvd stveeerlre nrnhekywyr wgpylsersw atvredysln gdawsnfpfe 61 hanarvfrwg edglfgvsdn kqlvcmnval wngkderlke rlfgltgpqg nhgedvkely 121 fyldntpths ymkalykypf kkafpykelv qkngergyed kefevydidg lyrdsetgdn 181 pyfdvffema kddenpseln frltihnrsk idsgelyiap qlffrntwaf dgtrtkdkpl 241 lerdaeaanl inmthkkygn cqmvfqpspg gfssgtneee edkevedidp lllftdnesn 301 lvklfneekn pseytkdafe eylvqgktda vnpenkgtka cavyhfknip pgeyvtvryk 361 ftndpknsif kaqnlavvde defdlifdnr eeeadnfywr itplpisdel rnlqrqafsg 421 llwtkqfynf tydawyngda nvkprpppnr angrnknwkh lyiedilsmp dkweypffas 481 wdtafhcipl amidpefakr qldlltrewy mhpngqipay ewnfndvnpp vhawavyrvf 541 kiernmynre drtflervfq klllnftwwv nrkdtegknv feggflgldn igvfnrsepl 601 ptggtleqad stgwmaffsl qmlnialela kenpvyedia skffehfili sdsmsfeyat 661 ditgekckev ikqnlwnead kfyydaiswg dhkvqlpirs lvgliplyas mtlepsiikq 721 frgfkkrvdw fvnnrpeifd rniasmskkg vgerlllslv tkerltails rlldetefls 781 pygirslsky hekhpfemnv ngveymvkyl pgesdsgmfg gnsnwrgpiw fptsflimea 841 lqrfylyygs dfkvecpvgs gdylnlaeva eelgyrmihl fvpdengera ihygdhskfl 901 ssdpyfrdyv pffeyfdgdt grglgashqc gwtalvakwi sdvgiscvrl prtprssvat 961 tastesseqg pkmkrmarrk sakslvnyta tildlteeek rhhriggths gltpqssiss 1021 dkarhlmeem neeegihetv vpedrhnfet kligklkdkv knmkvtdkak dedidpmdpm 1081 splnkdvs // LOCUS NP_013924 217 aa linear PLN 30-JUN-2025 DEFINITION v-SNARE protein VTI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013924 VERSION NP_013924.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182704.1 REFERENCE 1 (residues 1 to 217) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 217) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 217) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 217) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10096. Method: conceptual translation. FEATURES Location/Qualifiers source 1..217 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..217 /product="v-SNARE protein VTI1" /calculated_mol_wt="24537" Region 12..92 /region_name="V-SNARE" /note="Vesicle transport v-SNARE protein N-terminus; pfam05008" /db_xref="CDD:461516" Region 127..185 /region_name="SNARE_Vti1" /note="SNARE motif of Vti1; cd15862" /db_xref="CDD:277215" Site order(129..130,133..134,136..138,140..145,147..149, 151..152,154..155,158..159,161..166,168..170,172..173, 175..180,182..183) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277215" Site 158 /site_type="active" /note="zero layer [active]" /db_xref="CDD:277215" CDS 1..217 /gene="VTI1" /locus_tag="YMR197C" /coded_by="NM_001182704.1:1..654" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:9398683]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:19805279]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11739407]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:9398683]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:9199167]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11694599]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10385523]" /experiment="EXISTENCE:physical interaction:GO:0031201 SNARE complex [PMID:10397773]" /note="Golgi membrane protein and Qb class v-SNARE; involved in cis-Golgi membrane traffic; interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways; human homolog VTI1A can complement the yeast null mutant" /db_xref="GeneID:855237" /db_xref="SGD:S000004810" ORIGIN 1 mssllisyes dfkttleqak aslaeapsqp lsqrnttlkh veqqqdelfd lldqmdvevn 61 nsigdasera tykaklrewk ktiqsdikrp lqslvdsgdr drlfgdlnas nidddqrqql 121 lsnhailqks gdrlkdasri anetegigsq immdlrsqre tlenarqtlf qadsyvdksi 181 ktlktmtrrl vankfisyai iavlillill vlfskfk // LOCUS NP_013925 594 aa linear PLN 30-JUN-2025 DEFINITION Cik1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013925 VERSION NP_013925.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182705.1 REFERENCE 1 (residues 1 to 594) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 594) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 594) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 594) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10097. Method: conceptual translation. FEATURES Location/Qualifiers source 1..594 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..594 /product="Cik1p" /calculated_mol_wt="68939" Region 86..>373 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 357..480 /region_name="Microtub_bd" /note="Microtubule binding; pfam16796" /db_xref="CDD:465274" CDS 1..594 /gene="CIK1" /locus_tag="YMR198W" /coded_by="NM_001182705.1:1..1785" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:1644287|PMID:11729143]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:11729143]" /experiment="EXISTENCE:direct assay:GO:0005871 kinesin complex [PMID:10087265]" /experiment="EXISTENCE:direct assay:GO:0008569 minus-end-directed microtubule motor activity [PMID:16107877]" /experiment="EXISTENCE:direct assay:GO:0051321 meiotic cell cycle [PMID:11729143]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:1644287]" /experiment="EXISTENCE:mutant phenotype:GO:0000743 nuclear migration involved in conjugation with cellular fusion [PMID:19386762]" /experiment="EXISTENCE:mutant phenotype:GO:0003777 microtubule motor activity [PMID:10087265]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:11729143]" /experiment="EXISTENCE:mutant phenotype:GO:0060236 regulation of mitotic spindle organization [PMID:25313961]" /note="Kinesin-associated protein; required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; locus encodes a long and short transcript with differing functions; CIK1 has a paralog, VIK1, that arose from the whole genome duplication" /db_xref="GeneID:855238" /db_xref="SGD:S000004811" ORIGIN 1 mnnskipkls fhsdpnnvtr dfpktkrqkv qkremdmilt pnnnklnilh ssgsgirrcy 61 tddtsatytk kltfggdpki iervknnerk vrkdidslln aiseiekesv riharelpai 121 tleldakvka crelqneidg lstemdlkdn qcdlqrknve lssknivsmh avkvqefend 181 leeelsnakr ewtyklmeve nlkpderltd emrqlktefe evnrklfilq neneneckny 241 kkeldkkfei fkkvkndari eldgeqerls kvlkdlqdth gelkeniktc rdefndfekr 301 igeaevnfhs melavvplkk klastsqalt qvqeekkqve geannwkkky vnelekvqqe 361 lytrqnlats ieeikgytrc fayanerqmp defhinyvdr cicensgekr vqvfdrvvle 421 eihkdhkrly necipfleky isklincsii vvsqqptapm kktllkqlie qygenykmtl 481 nilhldgsik hsdvgldnpt eirdlsqdee cmniltldtk lgkdeeshsm niyigsmstv 541 qlnrelddap svlshiltkt kqcfvfkina geniekalal agklkrtitl pqld // LOCUS NP_013926 546 aa linear PLN 30-JUN-2025 DEFINITION cyclin CLN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013926 VERSION NP_013926.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182706.1 REFERENCE 1 (residues 1 to 546) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 546) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 546) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 546) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10098. Method: conceptual translation. FEATURES Location/Qualifiers source 1..546 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..546 /product="cyclin CLN1" /calculated_mol_wt="61919" Region 31..539 /region_name="COG5024" /note="Cyclin [Cell division and chromosome partitioning]" /db_xref="CDD:227357" Site order(91,127,158..160,178,181..182) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410262" CDS 1..546 /gene="CLN1" /locus_tag="YMR199W" /coded_by="NM_001182706.1:1..1641" /experiment="EXISTENCE:direct assay:GO:0001932 regulation of protein phosphorylation [PMID:8387915|PMID:10409718]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:10409718|PMID:8387915]" /experiment="EXISTENCE:genetic interaction:GO:0007089 traversing start control point of mitotic cell cycle [PMID:2147225|PMID:2574633]" /note="G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1" /db_xref="GeneID:855239" /db_xref="SGD:S000004812" ORIGIN 1 mnhsevktgl ivtakqtyyp ielsnaellt hyetiqeyhe eisqnvlvqs sktkpdikli 61 dqqpemnphq treaivtfly qlsvmtrvsn giffhavrfy drycskrvvl kdqaklvvgt 121 clwlaaktwg gcnhiinnvs iptggrfygp nprariprls elvhycggsd lfdesmfiqm 181 erhildtlnw dvyepmindy ilnvdencli qyelyknqlq nnnsngkews ckrksqssdd 241 sdatveehis sspqstgldg dtttmdedee lnskiklinl krflidlscw qynllkfely 301 eicngmfsii nkftnqdqgp flsmpigndi nsntqtqvfs iiingivnsp pslvevykeq 361 ygivpfilqv kdynlelqkk lqlastidlt rkiavnsryf dqnassssvs spstyssgtn 421 ytpmrnfsaq sdnsvfsttn idhsspitph mytfnqfkne sacdsaisvs slpnqtqngn 481 mplssnyqnm mleernkenr ipnsssaeip qrakfmttgi fqntgeltnr assislslrn 541 hnssql // LOCUS NP_013927 256 aa linear PLN 30-JUN-2025 DEFINITION Rot1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013927 VERSION NP_013927.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182707.1 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10099. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..256 /product="Rot1p" /calculated_mol_wt="28777" Region 31..253 /region_name="Rot1" /note="Chaperone for protein-folding within the ER, fungal; pfam10681" /db_xref="CDD:431433" CDS 1..256 /gene="ROT1" /locus_tag="YMR200W" /coded_by="NM_001182707.1:1..771" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:16567426]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:18508919]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:16874095]" /experiment="EXISTENCE:genetic interaction:GO:0006487 protein N-linked glycosylation [PMID:22492205]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:17606994]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:16874095]" /experiment="EXISTENCE:genetic interaction:GO:0035269 protein O-linked mannosylation [PMID:22492205]" /experiment="EXISTENCE:mutant phenotype:GO:0006458 'de novo' protein folding [PMID:18508919]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:17606994]" /experiment="EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:9545237]" /experiment="EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:17606994]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:18508919]" /experiment="EXISTENCE:physical interaction:GO:0006458 'de novo' protein folding [PMID:18508919]" /experiment="EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:22492205]" /note="Molecular chaperone involved in protein folding in ER; mutation causes defects in cell wall synthesis and lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation; transmembrane helix Ser250 is essential for Rot1p to interact with other membrane components and exert its functional role, avoiding exposure of Ser H-bonding group at lipid-exposed surface" /db_xref="GeneID:855240" /db_xref="SGD:S000004813" ORIGIN 1 mwskkftlkk lilggylfaq kvycedesns iygtwssksn qvftgpgfyd pvdellieps 61 lpglsysfte dgwyeeatyq vsgnprnptc pmasliyqhg tynisengtl vlnpievdgr 121 qlfsdpcndd gvstysrynq tetfkeyavg idpyhgiytl qlyqydgtpm qplylayrpp 181 mmlptetlnp tssatstddp ssnkkrslrs lvrrslenrh ktnaikrqnt sfltsnaiwy 241 isagmlgvgs llflaf // LOCUS NP_013928 371 aa linear PLN 30-JUN-2025 DEFINITION DNA repair protein RAD14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013928 VERSION NP_013928.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182708.1 REFERENCE 1 (residues 1 to 371) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 371) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 371) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 371) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10100. Method: conceptual translation. FEATURES Location/Qualifiers source 1..371 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..371 /product="DNA repair protein RAD14" /calculated_mol_wt="42907" Region 20..371 /region_name="RAD14" /note="DNA excision repair protein [DNA replication, recombination, and repair]; COG5145" /db_xref="CDD:227474" CDS 1..371 /gene="RAD14" /locus_tag="YMR201C" /coded_by="NM_001182708.1:1..1116" /experiment="EXISTENCE:direct assay:GO:0000715 nucleotide-excision repair, DNA damage recognition [PMID:8516285]" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:8516285|PMID:23925126]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9852079]" /experiment="EXISTENCE:direct assay:GO:0006974 DNA damage response [PMID:23925126]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:8516285]" /experiment="EXISTENCE:physical interaction:GO:0000110 nucleotide-excision repair factor 1 complex [PMID:8621533]" /note="Subunit of Nucleotide Excision Repair Factor 1 (NEF1); recognizes and binds damaged DNA during nucleotide excision repair (NER); also involved in regulation of transcription; contains zinc finger motif; homolog of human XPA protein" /db_xref="GeneID:855241" /db_xref="SGD:S000004814" ORIGIN 1 mtpeqkakle anrklaierl rkrgilssdq lnriesrnep lktrplavts gsnrddnaaa 61 avhvpnhngq psalantntn ttslygsgvv dgskrdasvl dkrptdrirp sirkqdyiey 121 dfatmqnlng gyinpkdklp nsdftddqef esefgskkqk tlqdwkkeql erkmlyenap 181 ppehiskapk ciechiniem dpvlhdvfkl qvckqcskeh pekyalltkt eckedyfltd 241 pelndedlfh rlekpnphsg tfarmqlfvr ceveafafkk wggeegldee wqrreegkah 301 rrekkyekki kemrlktraq eytnrlrekk hgkahihhfs dpvdggided gyqiqrrrct 361 dcgleteeid i // LOCUS NP_013929 222 aa linear PLN 30-JUN-2025 DEFINITION C-8 sterol isomerase ERG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013929 VERSION NP_013929.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182709.1 REFERENCE 1 (residues 1 to 222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 222) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10101. Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..222 /product="C-8 sterol isomerase ERG2" /calculated_mol_wt="24765" Region 23..216 /region_name="ERG2_Sigma1R" /note="ERG2 and Sigma1 receptor like protein; pfam04622" /db_xref="CDD:461372" CDS 1..222 /gene="ERG2" /locus_tag="YMR202W" /gene_synonym="END11" /coded_by="NM_001182709.1:1..669" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000247 C-8 sterol isomerase activity [PMID:18459942]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:18459942]" /note="C-8 sterol isomerase; catalyzes isomerization of delta-8 double bond to delta-7 position at an intermediate step in ergosterol biosynthesis; transcriptionally down-regulated when ergosterol is in excess; mutation is functionally complemented by human EBP" /db_xref="GeneID:855242" /db_xref="SGD:S000004815" ORIGIN 1 mkffplllli gvvgyimnvl fttwlptnym fdpktlneic nsviskhnaa eglstedllq 61 dvrdalashy gdeyinryvk eewvfnnagg amgqmiilha svseylilfg tavgteghtg 121 vhfaddyfti lhgtqiaalp yateaevytp gmthhlkkgy akqysmpggs falelaqgwi 181 pcmlpfgfld tfsstldlyt lyrtvyltar dmgknllqnk kf // LOCUS NP_013930 387 aa linear PLN 30-JUN-2025 DEFINITION TOM complex pore protein TOM40 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013930 VERSION NP_013930.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182710.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10102. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..387 /product="TOM complex pore protein TOM40" /calculated_mol_wt="41907" Region 57..360 /region_name="Porin3_Tom40" /note="Translocase of outer mitochondrial membrane 40 (Tom40); cd07305" /db_xref="CDD:132766" CDS 1..387 /gene="TOM40" /locus_tag="YMR203W" /gene_synonym="ISP42; MOM38" /coded_by="NM_001182710.1:1..1164" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9774109]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:15590639]" /note="Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions" /db_xref="GeneID:855243" /db_xref="SGD:S000004816" ORIGIN 1 msaptplaea sqiptipals pltakqskgn ffssnpissf vvdtykqlhs hrqslelvnp 61 gtvenlnkev srdvflsqyf ftglradlnk afsmnpafqt shtfsigsqa lpkyafsalf 121 andnlfaqgn idndlsvsgr lnygwdkkni skvnlqisdg qptmcqleqd yqasdfsvnv 181 ktlnpsfsek geftgvavas flqsvtpqla lgletlysrt dgsapgdagv syltryvskk 241 qdwifsgqlq angaliaslw rkvaqnveag iettlqagmv pitdplmgtp igiqptvegs 301 ttigakyeyr qsvyrgtlds ngkvacfler kvlptlsvlf cgeidhfknd tkigcglqfe 361 tagnqellml qqgldadgnp lqalpql // LOCUS NP_013931 420 aa linear PLN 30-JUN-2025 DEFINITION Inp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013931 VERSION NP_013931.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182711.1 REFERENCE 1 (residues 1 to 420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 420) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10103. Method: conceptual translation. FEATURES Location/Qualifiers source 1..420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..420 /product="Inp1p" /calculated_mol_wt="47184" Region 79..260 /region_name="Inp1" /note="Inheritance of peroxisomes protein 1; pfam12634" /db_xref="CDD:432685" CDS 1..420 /gene="INP1" /locus_tag="YMR204C" /coded_by="NM_001182711.1:1..1263" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:23900285|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:23900285]" /experiment="EXISTENCE:mutant phenotype:GO:0045033 peroxisome inheritance [PMID:15928207]" /note="Peripheral membrane protein of peroxisomes; involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane; Inp1p and Pex3p tether peroxisomes to plasma membrane" /db_xref="GeneID:855244" /db_xref="SGD:S000004817" ORIGIN 1 mvlsrgetkk nsvrltakqe kkpqstfqtl kqslklsnnk klkqdstqhs ndtnksvkak 61 kngtsskktg tqrkristqr fslftygnvq vmnsfvpihn dipnsscirr nsqvsannvt 121 essgvffndt qsqdsqntik lkptslmakg pieiyqictg fdklkeniap fqksskassh 181 dghvvnylsi grhgdivhpv lpklqitrln gagfkyfisf ynperyweie flplisqsqs 241 elensvkafe nviskicqfs hinegatign neslsdkfkl pptsdieppn teiinndddn 301 dddddnyddd dlnylldeey eqgctdnsfs visntcsnln asflypsdpt davsisinea 361 fknairrtap vlnipiaaps ihskqqnkry ssypfidspp ylqdrhrrfq rrsisglgdl // LOCUS NP_013932 959 aa linear PLN 30-JUN-2025 DEFINITION 6-phosphofructokinase subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_013932 VERSION NP_013932.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182712.1 REFERENCE 1 (residues 1 to 959) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 959) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 959) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 959) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 959) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 959) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 959) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10104. Method: conceptual translation. FEATURES Location/Qualifiers source 1..959 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..959 /product="6-phosphofructokinase subunit beta" /EC_number="2.7.1.11" /calculated_mol_wt="104487" Region 197..957 /region_name="6PF1K_euk" /note="6-phosphofructokinase, eukaryotic type; TIGR02478" /db_xref="CDD:274152" CDS 1..959 /gene="PFK2" /locus_tag="YMR205C" /coded_by="NM_001182712.1:1..2880" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:0005945 6-phosphofructokinase complex [PMID:6231961|PMID:4271029|PMID:21241708]" /experiment="EXISTENCE:direct assay:GO:0006096 glycolytic process [PMID:3000145]" /experiment="EXISTENCE:genetic interaction:GO:0003872 6-phosphofructokinase activity [PMID:3007939]" /experiment="EXISTENCE:genetic interaction:GO:0006096 glycolytic process [PMID:2965996]" /experiment="EXISTENCE:mutant phenotype:GO:0003872 6-phosphofructokinase activity [PMID:3007939]" /experiment="EXISTENCE:mutant phenotype:GO:0006096 glycolytic process [PMID:27226568|PMID:2965996]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:24860096]" /experiment="EXISTENCE:mutant phenotype:GO:0051453 regulation of intracellular pH [PMID:24860096]" /experiment="EXISTENCE:mutant phenotype:GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly [PMID:24860096]" /note="Beta subunit of heterooctameric phosphofructokinase; involved in glycolysis; indispensable for anaerobic growth; activated by fructose-2,6-bisphosphate and AMP; mutation inhibits glucose induction of cell cycle-related genes" /db_xref="GeneID:855245" /db_xref="SGD:S000004818" ORIGIN 1 mtvttpfvng tsyctvtays vqsykaaidf ytkflslenr sspdenstll sndsislkil 61 lrpdekinkn veahlkelns itktqdwrsh atqslvfnts dilavkdtln amnaplqgyp 121 telfpmqlyt ldplgnvvgv tstknavstk ptpppapeas aesglsskvh sytdlayrmk 181 ttdtypslpk plnrpqkaia vmtsggdapg mnsnvraivr saifkgcraf vvmegyeglv 241 rggpeyikef hwedvrgwsa eggtnigtar cmefkkregr llgaqhliea gvdalivcgg 301 dgsltgadlf rsewpsliee llktnrisne qyermkhlni cgtvgsidnd msttdatiga 361 ysaldricka idyveatans hsrafvvevm grncgwlall agiatsadyi fipekpatss 421 ewqdqmcdiv skhrsrgkrt tivvvaegai aadltpisps dvhkvlvdrl gldtrittlg 481 hvqrggtava ydrilatlqg leavnavles tpdtpsplia vnenkivrkp lmesvkltka 541 vaeaiqakdf kramslrdte fiehlnnfma insadhnepk lpkdkrlkia ivnvgapagg 601 insavysmat ycmsqghrpy aiyngwsgla rhesvrslnw kdmlgwqsrg gseigtnrvt 661 peeadlgmia yyfqkyefdg liivggfeaf eslhqlerar esypafripm vlipatlsnn 721 vpgteyslgs dtalnalmey cdvvkqsass trgrafvvdc qggnsgylat yaslavgaqv 781 syvpeegisl eqlsedieyl aqsfekaegr grfgklilks tnaskalsat klaevitaea 841 dgrfdakpay pghvqqgglp spidrtratr maikavgfik dnqaaiaear aaeenfnadd 901 ktisdtaavv gvkgshvvyn sirqlydyet evsmrmpkvi hwqatrliad hlvgrkrvd // LOCUS NP_013933 313 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR206W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013933 VERSION NP_013933.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182713.1 REFERENCE 1 (residues 1 to 313) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 313) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 313) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 313) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10105. Method: conceptual translation. FEATURES Location/Qualifiers source 1..313 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..313 /product="uncharacterized protein" /calculated_mol_wt="34887" Region 4..309 /region_name="DUF4667" /note="Domain of unknown function (DUF4667); pfam15700" /db_xref="CDD:406191" CDS 1..313 /locus_tag="YMR206W" /coded_by="NM_001182713.1:1..942" /note="hypothetical protein; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication" /db_xref="GeneID:855246" /db_xref="SGD:S000004819" ORIGIN 1 mlssssnrpi sahltihyka iqeeegedmr sgagsgghhd dyflesnrsp tpnkkhefik 61 tvlnindnds efsescspre klhnegacnt dlfgdfmskr qqrlsnsmni ydlyqcvhnl 121 spsnnnhqfi arrfsdship slhhrqqqqk vttknfvqpt kdiqriasya adsdqrvkyl 181 pnyhqsapst alsaaeskaa vprklpdrds tqnyvlklql sspnsqpmsp rtrpgyrpsc 241 sssncsssss ssacssvsis dpnnitayet nnvnpqfpsn qpldisspca rhhhrrnsia 301 vkfdkalykk ttg // LOCUS NP_013934 2123 aa linear PLN 30-JUN-2025 DEFINITION acetyl-CoA carboxylase HFA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013934 VERSION NP_013934.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182714.1 REFERENCE 1 (residues 1 to 2123) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2123) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 2123) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2123) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2123) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10106. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2123 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..2123 /product="acetyl-CoA carboxylase HFA1" /EC_number="6.3.4.14" /EC_number="6.4.1.2" /calculated_mol_wt="241656" Region 22..507 /region_name="PccA" /note="Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]; COG4770" /db_xref="CDD:443802" Region 621..686 /region_name="biotinyl_domain" /note="The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; cd06850" /db_xref="CDD:133459" Site order(644,653..655,662) /site_type="active" /note="carboxyltransferase (CT) interaction site [active]" /db_xref="CDD:133459" Site 654 /site_type="other" /note="biotinylation site [posttranslational modification]" /db_xref="CDD:133459" Region 687..1371 /region_name="ACC_central" /note="Acetyl-CoA carboxylase, central region; pfam08326" /db_xref="CDD:462429" Region 1469..2026 /region_name="Carboxyl_trans" /note="Carboxyl transferase domain; pfam01039" /db_xref="CDD:426008" CDS 1..2123 /gene="HFA1" /locus_tag="YMR207C" /coded_by="NM_001182714.1:1..6372" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22842922|PMID:14576278|PMID:14562095|PMID:14761959|P MID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0003989 acetyl-CoA carboxylase activity [PMID:14761959]" /experiment="EXISTENCE:genetic interaction:GO:0042759 long-chain fatty acid biosynthetic process [PMID:14761959]" /note="Mitochondrial acetyl-coenzyme A carboxylase; catalyzes production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress; genetic and comparative analysis suggests that translation begins at a non-canonical (Ile) start codon at -372 relative to the annotated start codon" /db_xref="GeneID:855247" /db_xref="SGD:S000004820" ORIGIN 1 mrsirkwaye tfndekiiqf vvmatpddlh anseyirmad qyvqvpggtn nnnyanidli 61 ldvaeqtdvd avwagwghas enpclpella ssqrkilfig ppgramrslg dkisstivaq 121 sakipcipws gshidtihid nktnfvsvpd dvyvrgccss pedalekakl igfpvmikas 181 eggggkgirr vdneddfial yrqavnetpg spmfvmkvvt darhlevqll adqygtnitl 241 fgrdcsiqrr hqkiieeapv titkpetfqr meraairlge lvgyvsagtv eylyspkddk 301 fyflelnprl qvehpttemi sgvnlpatql qiamgipmhm isdirklygl dptgtsyidf 361 knlkrpspkg hciscritse dpnegfkpst gkihelnfrs ssnvwgyfsv gnngaihsfs 421 dsqfghifav gndrqdakqn mvlalkdfsi rgefktpiey lielletrdf esnnistgwl 481 ddlilknlss dskldptlai icgaamkayv ftekvrnkyl ellrrgqvpp kdflktkfpv 541 dfifdnnryl fnvaqsseeq filsinksqc evnvqklssd cllisvdgkc htvywkddir 601 gtrlsidsnt ifleaelnpt qvisptpgkl vkylvrsgdh vfagqqyaei eimkmqmplv 661 aksdgviell rqpgsiieag dviakltlds pskanessly rgelpvlgpp liegsrpnhk 721 lrvlinrlen ilngyhensg iettlkelik ilrdgrlpys ewdsqistvr nrlprqlneg 781 lgnlvkksvs fpakelhklm kryleentnd hvvyvalqpl lkiseryseg lanheceifl 841 klikkyyave kifenhdihe ernllnlrrk dltnlkkilc islshanvva knklvtailh 901 eyeplcqdss kmslkfravi hdlasleskw akevavkars vllrgifppi kkrkehiktl 961 lqlhikdtga enihsrniys cmrdfgnlih snliqlqdlf fffghqdtal ssiaseiyar 1021 yaygnyqlks ikihkgapdl lmswqfsslr nylvnsdges deftklskpp stsgkssans 1081 fgllvnmral eslektldev yeqihipeer lssgensliv nilspiryrs endliktlki 1141 klhenergls klkvnritfa fiaanapavk fysfdgttyd eisqirnmdp syeaplelgk 1201 msnykirslp tydssirife giskftpldk rffvrkiins fmyndqktte enlkaeinaq 1261 vvymlehlga vdisnsdlnh iflsfntvln ipvhrleeiv stilkthetr lfqeritdve 1321 icisveclet kkpaplrlli snksgyvvki etyyekigkn gnlilepcse qshysqksls 1381 lpysvkdwlq pkrykaqfmg ttyvydfpgl fhqaaiqqwk ryfpkhklnd sffswvelie 1441 qngnlikvnr epglnnigmv afeimvqtpe ypegrnmivi snditynigs fgpredlffd 1501 rvtnyarerg ipriylaans gaklgiaeel iplfrvawnd psdptkgfqy lylapkdmql 1561 lkdsgkgnsv vvehkmvyge eryiikaivg feeglgvecl qgsgliagat skayrdifti 1621 tavtcrsvgi gsylvrlgqr tiqvedkpii ltgasainkv lgtdiytsnl qiggtqimyk 1681 ngiahltasn dmkaiekimt wlsyvpakrd mspplletmd rwdrdvdfkp akqvpyearw 1741 liegkwdsnn nfqsglfdkd sffetlsgwa kgvivgrarl ggipvgviav etktieeiip 1801 adpanldsse fsvkeagqvw ypnsafktaq tindfnygeq lpliilanwr gfsggqrdmy 1861 nevlkygsfi vdalvdykqp iliyippfge lrggswvvid ptinpeqmem yadvesrggv 1921 lepdgvvsik yrkekmietm irldstyghl rrtltekkls lekqndltkr lkirerqlip 1981 iynqisiqfa dlhdrstrml vkgvirnele wkksrrflyw rlrrrlnegq vikrlqkktc 2041 dnktkmkydd llkivqswyn dldvnddrav vefiernskk idknieefei sllidelkkk 2101 fedrrgnivl eeltrlvdsk rkr // LOCUS NP_013935 443 aa linear PLN 30-JUN-2025 DEFINITION mevalonate kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013935 VERSION NP_013935.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182715.1 REFERENCE 1 (residues 1 to 443) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 443) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 443) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 443) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10107. Method: conceptual translation. FEATURES Location/Qualifiers source 1..443 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..443 /product="mevalonate kinase" /EC_number="2.7.1.36" /calculated_mol_wt="48329" Region 9..361 /region_name="mevalon_kin" /note="mevalonate kinase; TIGR00549" /db_xref="CDD:273130" CDS 1..443 /gene="ERG12" /locus_tag="YMR208W" /gene_synonym="RAR1" /coded_by="NM_001182715.1:1..1332" /experiment="EXISTENCE:direct assay:GO:0004496 mevalonate kinase activity [PMID:1645230|PMID:16477420]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:1645230]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:200835]" /experiment="EXISTENCE:mutant phenotype:GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway [PMID:200835]" /experiment="EXISTENCE:mutant phenotype:GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway [PMID:200835]" /note="Mevalonate kinase; acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate; human MVK functionally complements the lethality of the erg12 null mutation" /db_xref="GeneID:855248" /db_xref="SGD:S000004821" ORIGIN 1 mslpfltsap gkviifgehs avynkpavaa svsalrtyll isessapdti eldfpdisfn 61 hkwsindfna itedqvnsqk lakaqqatdg lsqelvslld pllaqlsesf hyhaafcfly 121 mfvclcphak nikfslkstl pigaglgssa sisvslalam aylggligsn dleklsendk 181 hivnqwafig ekcihgtpsg idnavatygn allfekdshn gtintnnfkf lddfpaipmi 241 ltytriprst kdlvarvrvl vtekfpevmk pildamgeca lqgleimtkl skckgtddea 301 vetnnelyeq llelirinhg llvsigvshp gleliknlsd dlrigstklt gaggggcslt 361 llrrditqeq idsfkkklqd dfsyetfetd lggtgcclls aknlnkdlki kslvfqlfen 421 ktttkqqidd lllpgntnlp wts // LOCUS NP_013936 457 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR209C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013936 VERSION NP_013936.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182716.1 REFERENCE 1 (residues 1 to 457) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 457) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 457) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 457) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 457) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10108. Method: conceptual translation. FEATURES Location/Qualifiers source 1..457 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..457 /product="uncharacterized protein" /calculated_mol_wt="52115" Region 192..457 /region_name="CARME" /note="Carnosine N-methyltransferase; pfam07942" /db_xref="CDD:400340" CDS 1..457 /locus_tag="YMR209C" /coded_by="NM_001182716.1:1..1374" /note="Putative S-adenosylmethionine-dependent methyltransferase; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YMR209C is not an essential gene" /db_xref="GeneID:855249" /db_xref="SGD:S000004822" ORIGIN 1 mvsslasnii lalvvvlmtl lrqnkplqrw fvsyveklls rksnlaqkvs vlspslklvd 61 veksisadqs nlskinyqip tlpdltgnli rlheyrarge gyngllfrra rqlngisedq 121 lqklgyftkl mknnegiren arvidkiief tlgklihsne hdeefteeie kicaehgyki 181 kdghliqlnp dfvfpivssr gsqsvvheal ahlcrdfssy ysverdplqn fiisrinhhv 241 isagdmkeki livtpgagvg glshtlattf pkiqvdsiel salmyicnlf aleykhdvki 301 rpfvqqyscq tvfdnqlrsl sadlskvghr snldplwgdf tryspiskdy dkiiicsayf 361 idtaenmfey lssiealkky ckelhwvnvg plkygtkplv qftgdelsrl rkirgwkdlv 421 eeyevdsskg lngyltdyes myqgyygllk fhsvfes // LOCUS NP_013937 449 aa linear PLN 30-JUN-2025 DEFINITION putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013937 VERSION NP_013937.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182717.1 REFERENCE 1 (residues 1 to 449) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 449) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 449) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 449) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 449) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10109. Method: conceptual translation. FEATURES Location/Qualifiers source 1..449 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..449 /product="putative carboxylic ester hydrolase" /EC_number="3.1.1.23" /calculated_mol_wt="51307" Region 59..395 /region_name="PLN02511" /note="hydrolase" /db_xref="CDD:215282" CDS 1..449 /gene="MGL2" /locus_tag="YMR210W" /coded_by="NM_001182717.1:1..1350" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:29225428]" /experiment="EXISTENCE:direct assay:GO:0047372 monoacylglycerol lipase activity [PMID:26991558]" /experiment="EXISTENCE:genetic interaction:GO:0006641 triglyceride metabolic process [PMID:26991558]" /experiment="EXISTENCE:genetic interaction:GO:0047372 monoacylglycerol lipase activity [PMID:26991558]" /experiment="EXISTENCE:genetic interaction:GO:0051792 medium-chain fatty acid biosynthetic process [PMID:16361250]" /experiment="EXISTENCE:mutant phenotype:GO:0047372 monoacylglycerol lipase activity [PMID:26991558]" /note="Monoacylglycerol and triacylglycerol lipase; MAG lipase with preference for palmitoyl-MAG; TAG lipase involved in TAG catabolism; minor role in medium-chain fatty acid ethyl ester biosynthesis; contains an alpha/beta hydrolase domain and a typical lipase motif (GXSXG); similar to acyltransferases, Eeb1p, Eht1p, and human ABHD1" /db_xref="GeneID:855250" /db_xref="SGD:S000004823" ORIGIN 1 mrlkellpnf livhqevped piafkstdkr enenkeitip elidtkvpel adgatdtlyg 61 llvnghlqta ygsfrhfdni ykvqykrmii kyphggegtv dfavngrstk rrkvekeyvp 121 tsqpvfngnl krrysyyspd dpklnsddak pmliilhglt ggsresyvra ivheittkyd 181 feacvfnarg ccysaittpl lynggwtndi rycvndlrkr fpnrkfymmg fslgasimtn 241 ylgeesdrtk iecaisvsnp fdlynsayfi nstpmgsrfy spalghnllr mvrnhlstle 301 enpdfkdvie khlkkirtvr qfdnlltgpm fgyknaeeyy knassykrip girtpfialh 361 aqddpivggd lpidqiksnp ytllletstg ghvgwfkdrs grrwyaeplc rflkifhdei 421 tvkglkpdle nvqlpdpnce piattfran // LOCUS NP_013938 475 aa linear PLN 30-JUN-2025 DEFINITION Dml1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013938 VERSION NP_013938.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182718.1 REFERENCE 1 (residues 1 to 475) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 475) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 475) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 475) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10110. Method: conceptual translation. FEATURES Location/Qualifiers source 1..475 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..475 /product="Dml1p" /calculated_mol_wt="55181" Region 2..>290 /region_name="Tubulin_FtsZ_Cetz-like" /note="Tubulin protein family of FtsZ and CetZ-like; cl10017" /db_xref="CDD:471962" CDS 1..475 /gene="DML1" /locus_tag="YMR211W" /coded_by="NM_001182718.1:1..1428" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14690591]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:12702300]" /experiment="EXISTENCE:mutant phenotype:GO:0006276 plasmid maintenance [PMID:12702300]" /note="Essential protein involved in mtDNA inheritance; may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family" /db_xref="GeneID:855251" /db_xref="SGD:S000004824" ORIGIN 1 mhevvtisvs qranhlttqf fniqegylql skeqqvndsk iflnsvvdkv sktisyapra 61 llwdartgng slgtyqyses qdyhfgnedk fkeqtvikth pripkseyqs sldagaplpc 121 lnrentmyws dyskliygps sfnilrnwyh dtenpnqpdf qnlgerkfdr ysigydefte 181 nylqeffdgn lhrelekcdt lqgfnlvsdm esgwggfssa llvelrnelp kkavfswghn 241 eddpftddfp mkrlskkwlp iisnklrsti nmmqesdlyf plyaapgltn wetagkscri 301 fdsinatisq snleqrktmd ylttaitlgy ssrnmvtgmv igdtdysfcs rvlpfknshk 361 pnsthifsks fidrgnqthk hhsepdsrsk miemythryf psdtiptefs ndrefvlele 421 sseknrdifk hwnefvvryf kndsdreelk nelsdyasay esgwyededs gdddm // LOCUS NP_013939 782 aa linear PLN 30-JUN-2025 DEFINITION Efr3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013939 VERSION NP_013939.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182719.1 REFERENCE 1 (residues 1 to 782) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 782) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 782) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 782) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10111. Method: conceptual translation. FEATURES Location/Qualifiers source 1..782 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..782 /product="Efr3p" /calculated_mol_wt="89060" CDS 1..782 /gene="EFR3" /locus_tag="YMR212C" /coded_by="NM_001182719.1:1..2349" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19075114]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0072659 protein localization to plasma membrane [PMID:19075114]" /note="Protein required for Stt4-containing PI kinase complex localization; required for Stt4-containing phosphoinositide (PI) kinase patch assembly at plasma membrane; recruited to plasma membrane via conserved basic patch near N-terminus; exhibits synthetic lethal genetic interactions with PHO85; mutations in human homolog EFR3A implicated in autism spectrum disorders" /db_xref="GeneID:855252" /db_xref="SGD:S000004825" ORIGIN 1 mqlsmrmmft pkhqklvnqc yptgrttdkk pkssetsyll yyvnsrrskl ekvstylikr 61 stsdlnhrri gniavtldlm nkivlhcken lnvfvkdfly imnkvlsnnn fnndvsvvel 121 ielafssicq nlddvlcngd mefvqlyqnf vdlffkivte rihnddmllk ccidisntns 181 vssnpqlnhf vsksvaytis kfqernpkfk tlsleaales nlgkrlsrtq trtigldkaa 241 ednhdlsvka lqsyfnttet dklnlsirtl lrclqstpnk ellefvcngi pvqlryivil 301 llvrqlsdkd knvnpivslk lmssllvsdv sivglsvldi mrkllnfqlk natnkevvaq 361 scitmtdlnh ktyyaeqtsd mlyelllklk sdtvkdvekn avvedidflv ehitqpsisl 421 elfidlahym knhiiclfni vetevpssil fsklysllre ldshgvqkem meeifdkygk 481 mallsglnyf lenvsepeyt yysyhlqaan flklndyksq teykmqtrtl ftkedllsyy 541 sdtgsnkysk kgaqillsrd nqistsdlls dsqvrttple yknvpnaifs ngkavydnnd 601 faakqnkfdn siddnieean dtvisdanak gsiyrfvaed arswktmrat apkvsdlkkt 661 mneknipnnm krdgsfrgsq svksrvtnit fllnelktfs ddankikdpd eenivgldki 721 dvarsnslrl apisslsdrs signrksflq ktatgenqnd dfkdanedlh slssrgkifs 781 st // LOCUS NP_013940 590 aa linear PLN 30-JUN-2025 DEFINITION Cef1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013940 VERSION NP_013940.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182720.1 REFERENCE 1 (residues 1 to 590) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 590) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 590) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 590) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10112. Method: conceptual translation. FEATURES Location/Qualifiers source 1..590 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..590 /product="Cef1p" /calculated_mol_wt="67600" Region 1..491 /region_name="REB1" /note="Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]; COG5147" /db_xref="CDD:227476" CDS 1..590 /gene="CEF1" /locus_tag="YMR213W" /gene_synonym="NTC85" /coded_by="NM_001182720.1:1..1773" /experiment="EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:10092627]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:10092627]" /experiment="EXISTENCE:mutant phenotype:GO:0000350 generation of catalytic spliceosome for second transesterification step [PMID:22408182]" /experiment="EXISTENCE:mutant phenotype:GO:0000386 second spliceosomal transesterification activity [PMID:22408182]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10092627]" /note="Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p" /db_xref="GeneID:855253" /db_xref="SGD:S000004826" ORIGIN 1 mppvpiyvkg gvwtnvedqi lkaavqkygt hqwskvasll qkktarqsel rwneylnpkl 61 nftefskeed aqlldlarel pnqwrtiadm marpaqvcve rynrllesed sggaalstgv 121 tdlkagdinp naetqmarpd ngdledeeke mlaeararll ntqgkkatrk irermleesk 181 riaelqkrre lkqaginvai kkpkkkygtd idynedivye qapmpgiydt stedrqikkk 241 feqferkvnr kgldgnkdkp skknkdkkrk hdenehveka algesttltd eykkpklils 301 apgtkqgkvt ykkkleskrq klieaqatgt vltpkellph dsgqedners niksgkqlks 361 rirkflvqmf aslpspkndf eivlsedeke edaeiaeyek efeneramne ednfieppsq 421 ndaprvslva vplaystlpi pefknnpqsa idnkynllva nainkephmv pedtvdflke 481 vesrmqhitq grtsmkiqfk tampptevll esiqskvesi eqlqrklqhv qpleqqnnem 541 cstlchhslp aliegqrkyy adyyayrqei rslegrrkrl qamlnssssi // LOCUS NP_013941 377 aa linear PLN 30-JUN-2025 DEFINITION Scj1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013941 VERSION NP_013941.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182721.1 REFERENCE 1 (residues 1 to 377) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 377) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 377) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 377) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10113. On Oct 2, 2003 this sequence version replaced NP_013941.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..377 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..377 /product="Scj1p" /calculated_mol_wt="41412" Region 23..370 /region_name="DnaJ_bact" /note="chaperone protein DnaJ; TIGR02349" /db_xref="CDD:274090" CDS 1..377 /gene="SCJ1" /locus_tag="YMR214W" /coded_by="NM_001182721.1:1..1134" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005788 endoplasmic reticulum lumen [PMID:7744969]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:9817751]" /experiment="EXISTENCE:mutant phenotype:GO:0034975 protein folding in endoplasmic reticulum [PMID:9817751]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11381090]" /experiment="EXISTENCE:mutant phenotype:GO:0051087 protein-folding chaperone binding [PMID:9817751]" /note="One of several homologs of bacterial chaperone DnaJ; located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins" /db_xref="GeneID:855254" /db_xref="SGD:S000004827" ORIGIN 1 mipklyihli lsllllplil aqdyyailei dkdatekeik sayrqlskky hpdknagsee 61 ahqkfievge aydvlsdpek kkiydqfgad avkngggggg pggpgaggfh dpfdifermf 121 qgghggpggg fgqrqrqrgp mikvqeklsl kqfysgssie ftlnlndecd achgsgsadg 181 klaqcpdcqg rgviiqvlrm gimtqqiqqm cgrcggtgqi iknecktchg kkvtkknkff 241 hvdvppgapr nymdtrvgea ekgpdfdagd lviefkekdt enmgyrrrgd nlyrtevlsa 301 aealyggwqr tiefldenkp vklsrpahvv vsngevevvk gfgmpkgskg ygdlyidyvv 361 vmpktfksgq nmlkdel // LOCUS NP_013942 524 aa linear PLN 30-JUN-2025 DEFINITION putative 1,3-beta-glucanosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013942 VERSION NP_013942.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182722.1 REFERENCE 1 (residues 1 to 524) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 524) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 524) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 524) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10114. Method: conceptual translation. FEATURES Location/Qualifiers source 1..524 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..524 /product="putative 1,3-beta-glucanosyltransferase" /calculated_mol_wt="56663" Region 14..352 /region_name="Glycosyl hydrolases" /note="A functionally diverse superfamily containing glycosyl hydrolase families 1,5,10,17,44,72, and others; cl23725" /db_xref="CDD:474034" CDS 1..524 /gene="GAS3" /locus_tag="YMR215W" /coded_by="NM_001182722.1:1..1575" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:17507646]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953|PMID:15781460]" /note="Putative 1,3-beta-glucanosyltransferase; has similarity go other GAS family members; low abundance, possibly inactive member of the GAS family of GPI-containing proteins; localizes to the cell wall; mRNA induced during sporulation" /db_xref="GeneID:855255" /db_xref="SGD:S000004828" ORIGIN 1 mqlsksilla alaatpslvn amlpihikny rfikpssatn sesdnevffv kgvdyqpggs 61 sgydadsdtd ilsdpevcar dayafqqlgv ntvriyslnp dlnhdkcmti fnnagiyail 121 dvnsgnyges lnradpsgty dslylsrvfk fidafknypn vlgffsgnev indqsdyaki 181 dppyiravqr dmkqyiskha nrsipvgysa adntdlrlat fkylqcnsld gnkvnddldi 241 sksdffglnt yewcsgtssw essgydklns tfedavipli fseygcnknt prtfdevseg 301 lygglknvfs gglvyeytee annyglvkld dsgsltykdd fvnlesqlkn vslpttkese 361 issdsiykcd nsaitniysg fgtnnftlps qpaeianmie ygvngtntgk iltdyavptt 421 fnytiknnkd dtisatisyd kanslneldv tattvaksas tsqsssrslt sstspssstg 481 sssstgsssa sssskskgvg nivnvsfsqs gylalfagli sall // LOCUS NP_013943 742 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase SKY1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013943 VERSION NP_013943.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182723.1 REFERENCE 1 (residues 1 to 742) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 742) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 742) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 742) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 742) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10115. Method: conceptual translation. FEATURES Location/Qualifiers source 1..742 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..742 /product="serine/threonine protein kinase SKY1" /EC_number="2.7.11.1" /calculated_mol_wt="83107" Region 155..706 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(164..167,170,172,185,187,226,246..249,294,298..299, 301,549..550) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..742 /gene="SKY1" /locus_tag="YMR216C" /coded_by="NM_001182723.1:1..2229" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:11233987|PMID:17517895]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10318902]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:31399582]" /experiment="EXISTENCE:direct assay:GO:0035617 stress granule disassembly [PMID:31399582]" /experiment="EXISTENCE:genetic interaction:GO:0006376 mRNA splice site recognition [PMID:11565750]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:11113192]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:11585720]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:12225850]" /experiment="EXISTENCE:mutant phenotype:GO:0042307 positive regulation of protein import into nucleus [PMID:10952997]" /note="SR protein kinase (SRPK); involved in mRNA 3' splice site recognition with Prp8p and Cdc40p; phosphorylates one or more SR dipeptides on mRNA export factors Npl3p and Gbp2p to stimulate cytoplasmic release of mRNA and Mtr10p-mediated nuclear reimport; component of stress granules that regulates granule disassembly during recovery from stress; modulates cation uptake and homeostasis through membrane transporters; contains prion-like domains; similar to human SRPK1" /db_xref="GeneID:855256" /db_xref="SGD:S000004829" ORIGIN 1 mgssinypgf vtksahladt stdasiscee atssqeakkn ffqrdynmmk kapaptkskl 61 slalqtskss ssangtvqed tssktedfst ksikkkpdsg veshvsiqsd sgpqsdsdld 121 sdssisscde rneeslkdyr pggyhpafkg epykdaryil vrklgwghfs tvwlakdmvn 181 nthvamkivr gdkvyteaae deikllqrvn dadntkedsm ganhilklld hfnhkgpngv 241 hvvmvfevlg enllalikky ehrgipliyv kqiskqlllg ldymhrrcgi ihtdikpenv 301 lmeigdvegi vqmvealdkq kreakrlqrh vsrssditan dssdekwaec qtsmpcgsss 361 nsksrsiekd lskrcfrrpr rhtiitgsqp lpspisssnf femrahfcgs shnsfssvsg 421 nrnipssinn nsinngigik nsnnsflnsv phsvtrmfin edsndnnnnd nsknknnnnn 481 nsnnnnnedi mntplheeql adslstfdis nisqssdtng pyisntmdsn snvstdinsp 541 enliqikiad lgnacwydeh ytnsiqtrey rspevllgap wgcgadiwst aclifelitg 601 dflfepdegh sytkdddhia qiiellgelp syllrngkyt rtffnsrgll rnisklkfwp 661 ledvltekyk fskdeakeis dflspmlqld prkradaggl vnhpwlkdtl gmeeirvpdr 721 elygsgsdip gwfeevrdhk rh // LOCUS NP_013944 525 aa linear PLN 30-JUN-2025 DEFINITION GMP synthase (glutamine-hydrolyzing) [Saccharomyces cerevisiae S288C]. ACCESSION NP_013944 VERSION NP_013944.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182724.1 REFERENCE 1 (residues 1 to 525) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 525) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 525) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 525) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10116. Method: conceptual translation. FEATURES Location/Qualifiers source 1..525 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..525 /product="GMP synthase (glutamine-hydrolyzing)" /EC_number="6.3.5.2" /calculated_mol_wt="58351" Region 9..525 /region_name="guaA" /note="GMP synthase; Reviewed; PRK00074" /db_xref="CDD:234614" CDS 1..525 /gene="GUA1" /locus_tag="YMR217W" /coded_by="NM_001182724.1:1..1578" /experiment="EXISTENCE:mutant phenotype:GO:0003922 GMP synthase (glutamine-hydrolyzing) activity [PMID:8112582]" /experiment="EXISTENCE:mutant phenotype:GO:0006177 GMP biosynthetic process [PMID:20980241]" /note="GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-function mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA" /db_xref="GeneID:855257" /db_xref="SGD:S000004830" ORIGIN 1 maageqvsnm fdtilvldfg sqyshlitrr lrefniyaem lpctqkisel gwtpkgvils 61 ggpysvyaed aphvdhaifd lnvpilgicy gmqelawing kqvgrgdkre ygpatlkvid 121 dsnslfkgmn dstvwmshgd klhglptgyk tiatsdnspy cgivhetkpi ygiqfhpevt 181 hstqgktllk nfavdlchak qnwtmenfid teinrirklv gptaevigav sggvdstvas 241 klmteaigdr fhailvdngv lrlneaanvk ktlveglgin lmvvdaseef lsklkgvtdp 301 ekkrkiignt fihvfereae kikpkdgkei qfllqgtlyp dviesisfkg psqtikthhn 361 vggllenmkl klieplrelf kdevrhlgel lgiphdlvwr hpfpgpgiai rvlgevtkeq 421 veiarkadni yieeikkagl ynqisqafac llpvksvgvm gdqrtydqvi alraiettdf 481 mtadwfpfeh sflkkvasri vnevdgvarv tyditskppa tvewe // LOCUS NP_013945 1102 aa linear PLN 30-JUN-2025 DEFINITION transport protein particle complex II subunit TRS130 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013945 VERSION NP_013945.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182725.1 REFERENCE 1 (residues 1 to 1102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1102) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10117. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1102 /product="transport protein particle complex II subunit TRS130" /calculated_mol_wt="128000" Region 1003..1101 /region_name="TRAPPC10" /note="Trafficking protein particle complex subunit 10, TRAPPC10; pfam12584" /db_xref="CDD:403698" CDS 1..1102 /gene="TRS130" /locus_tag="YMR218C" /coded_by="NM_001182725.1:1..3309" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:16314430]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16314430]" /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]" /experiment="EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17041589]" /experiment="EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17041589]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:16314430|PMID:11239471]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:23078654]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:23078654]" /experiment="EXISTENCE:mutant phenotype:GO:0034498 early endosome to Golgi transport [PMID:16314430]" /experiment="EXISTENCE:physical interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:17041589]" /note="Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic" /db_xref="GeneID:855258" /db_xref="SGD:S000004831" ORIGIN 1 mdkeiycgsv pvsyfdpfdl feslrpefqq ilpldnihwk afdgtvrtvn rlpielipeg 61 rgeadksnde qpfirflivn cisidqyrak vrplvrqwlp nlesvssstg ekmiykpiil 121 lyansevvds nlfksvslme kfgkdfphvq tlevrsvyrs pkerqefwnq fsqkikasvl 181 sifqkrlthl qhslanlqkg nnfeeqlltr eklyelyvvf niledaslel qkikkeilrr 241 nmnmpdgklq vpfesssksd eslgsiiieg tldkfqlhky ffirrlrllk ledqtltafv 301 gafqliknfi esisieyrks vrllefkhyf itsmlsyfef envsnpllce ikaellmlkr 361 dnwvqgvmat sgyrlmdkny pnsdvkykfd llketfvdet vfqenfltlt keilslfnkc 421 egkrqrivdi lsieigllyy qgkkyeeavs lflscyeyyt qtnwnsiglk ilqvfidsls 481 hcpkldvlqi dgesvsasav ltnaflnilk lckdndskei wwkkfmdlqm knnihlmypl 541 dglfevtlns kvhlaranvs aievnlksyg fpedistktm rlslknmggd vivfgasdfl 601 lkkgenklil ecrdimygef sllsfeiive gitfvkefpe nqdefivvpe iyckestkvl 661 vkqahnlnlg eyalelksvq sdaleslqve vevqknignm knlpvsfsmd eiqarkrynt 721 pfenvrleyy lldqitafdl iiktsftkkn dqgtfgetkk vriqcylqls vsvedifkkd 781 ifffkfllns svreepvily sselsapdtr ndynirgdyi attpalitfd gnesfincye 841 itannnfdsk difnlkvryn tlkeqldcfi tdavliegdv ewfilfekwk tfweleilkk 901 lkydydafke nriirllkts idlnktkski rnlciekavl dkiliclnkv srgiavcntd 961 mdeyvrnlvp kqltvpvqlp gfeqffhvqf eqmetshdal hdtiatigns lsytvivenl 1021 sgqwgqdvid dggyifeils snewlihgqk rcaikekrke fevhliplkk gylnfprvei 1081 tningkscrv dhsnafesil if // LOCUS NP_013946 1658 aa linear PLN 30-JUN-2025 DEFINITION Esc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013946 VERSION NP_013946.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182726.1 REFERENCE 1 (residues 1 to 1658) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1658) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1658) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1658) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1658) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1658) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1658) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10118. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1658 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1658 /product="Esc1p" /calculated_mol_wt="187007" Region <175..442 /region_name="2A1904" /note="K+-dependent Na+/Ca+ exchanger; TIGR00927" /db_xref="CDD:273344" CDS 1..1658 /gene="ESC1" /locus_tag="YMR219W" /coded_by="NM_001182726.1:1..4977" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:27122604]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:12417731]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:12417731]" /experiment="EXISTENCE:mutant phenotype:GO:0034398 telomere tethering at nuclear periphery [PMID:27122604]" /note="Protein involved in telomeric silencing; required for quiescent cell telomere hypercluster localization at nuclear membrane vicinity; interacts with PAD4-domain of Sir4p" /db_xref="GeneID:855259" /db_xref="SGD:S000004832" ORIGIN 1 mskkketftp ranklklttp rrklkilssl ldadedskmk dqhgysrvhn dkyrvakptq 61 hstlhesiss rrsshihnks lhedsarals wvdslinrgk silttleked alfersleee 121 rqrfqlhdsl mnkytgnsks hqrlidlrks qygtdtsfqn ndeipldsfi ssplpdaede 181 sssnidsdkd edlegkqsli kdfdlendey elseeeknsd gqsspsimil sdeeyaeega 241 lqdvsndeya eeegqverkn igqeqanven atqisssdss egqnysegve meleddidve 301 sdaekdesqg aegtehsvdf skymqprtdn tkipviekye sdehkvhqry sedgafdfgs 361 vnisvddese deesqaesys anaenvyhhn ehelddkeli ediessdses qsaqeseqgs 421 eddfeykmkn ekstseeten tsesrdqgfa kdaytknkve qqendeepek ddiirssldk 481 nfhgnnnkse ysenvlenet dpaiverenq indvegydvt gksvesdlhe hspdnlydla 541 aramlqfqqs rnsncpqkee qvsesylghs ngsnlsgrsl deseeqiplk dftgennnnl 601 ktdrgdlsss veievekvse kkldgsteke lvplstdtti nnsslgneds iyyslddada 661 isenltdvpl meikttpkye vvisesvyss tsyedntvam ppqveytspf mndpfnslnd 721 dyekkhdllk stlaalapaf tkkdaefvea gvtkscltst sghtnifhts ketkqvsdld 781 estenvtfen entgdenknq sknfpgvans tdkstedntd ekyfsainyt nvtgdssced 841 iietasnvee nlrycekdmn eaemssgdec vkqnddgskt qisfstdspd nfqesndnte 901 fsstkykvrn sdleddeslk keltkaevvd kldeeeseds yeqdyadpep gndegsneni 961 vkgtkkdtlg ivepenekvn kvheeetlfe anvsssvnvq nkdmhtdvin qeaqanyeag 1021 erkyyiqntd teeahisiie ridenaignn meiperscve kthnevlfer rattientka 1081 lenntnmhdq vsqacsdsdr dqdstaeknv egsakhnldi rvssseiesv eplkpesdrs 1141 nifsspirvi gavvkgvgkv vdvaesfvkk idvmdsesdd nvdigdynqd ifnksnstda 1201 svnmksvssk erdsdedeav ilggvtaeah ndngnnsrvi nidpttngay eedsevfrqq 1261 vkdkenlhks eeplveglqs eqhfekkdhs eneeefdtiy gditsanihs napddikrqq 1321 llknlsdlen ysqrliedsr rgknqeesde vntsrerdlt feksvnekya gaieedtfse 1381 ldisiqhpeh eedldlsnnq ersieelnse peeaelyele iegptetaas skmndderqr 1441 gnipstdlps dppsdkeevt dsypysnsen itaeksapts pevyeifsdt pnevpmeind 1501 eipattlekh dktnvtsvld drsehlsshd vdnephdnsi nikvnegeep ehqavdipvk 1561 vevkeeqeem psksvleeqk psmelindks spennndeet nrekdktkak kksrkrnyns 1621 rrrkrkiteg ssaasntkrr rghepksrgq nthpsvdk // LOCUS NP_013947 451 aa linear PLN 30-JUN-2025 DEFINITION phosphomevalonate kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013947 VERSION NP_013947.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182727.1 REFERENCE 1 (residues 1 to 451) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 451) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 451) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 451) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10119. Method: conceptual translation. FEATURES Location/Qualifiers source 1..451 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..451 /product="phosphomevalonate kinase" /EC_number="2.7.4.2" /calculated_mol_wt="50324" Region 6..447 /region_name="Pmev_kin_ERG8" /note="phosphomevalonate kinase, ERG8-type, eukaryotic branch; TIGR01219" /db_xref="CDD:273509" CDS 1..451 /gene="ERG8" /locus_tag="YMR220W" /coded_by="NM_001182727.1:1..1356" /experiment="EXISTENCE:direct assay:GO:0004631 phosphomevalonate kinase activity [PMID:1846667]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:1846667]" /experiment="EXISTENCE:mutant phenotype:GO:0004631 phosphomevalonate kinase activity [PMID:1846667]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:200835]" /experiment="EXISTENCE:mutant phenotype:GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway [PMID:200835]" /experiment="EXISTENCE:mutant phenotype:GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway [PMID:200835]" /experiment="EXISTENCE:mutant phenotype:GO:0031388 organic acid phosphorylation [PMID:200835]" /note="Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate" /db_xref="GeneID:855260" /db_xref="SGD:S000004833" ORIGIN 1 mselrafsap gkallaggyl vldtkyeafv vglsarmhav ahpygslqgs dkfevrvksk 61 qfkdgewlyh ispksgfipv siggsknpfi ekvianvfsy fkpnmddycn rnlfvidifs 121 ddayhsqeds vtehrgnrrl sfhshrieev pktglgssag lvtvlttala sffvsdlenn 181 vdkyrevihn laqvahcqaq gkigsgfdva aaaygsiryr rfppalisnl pdigsatygs 241 klahlvdeed wnitiksnhl psgltlwmgd ikngsetvkl vqkvknwyds hmpeslkiyt 301 eldhansrfm dglskldrlh ethddysdqi feslerndct cqkypeitev rdavatirrs 361 frkitkesga dieppvqtsl lddcqtlkgv ltclipgagg ydaiavitkq dvdlraqtan 421 dkrfskvqwl dvtqadwgvr kekdpetyld k // LOCUS NP_013948 504 aa linear PLN 30-JUN-2025 DEFINITION Fmp42p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013948 VERSION NP_013948.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182728.1 REFERENCE 1 (residues 1 to 504) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 504) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 504) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 504) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10120. Method: conceptual translation. FEATURES Location/Qualifiers source 1..504 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..504 /product="Fmp42p" /calculated_mol_wt="56047" Region 8..486 /region_name="NarK" /note="Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; COG2223" /db_xref="CDD:441825" CDS 1..504 /gene="FMP42" /locus_tag="YMR221C" /coded_by="NM_001182728.1:1..1515" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:855261" /db_xref="SGD:S000004834" ORIGIN 1 mtstrtlrya qvacaciwcl fsagiifgfa alkpiliseg vyhelcdpkd gdrllctaqd 61 lklnfifals atvtnimalp vgkildmygp rvcgiigscl lflasgnfis akhlvslwdp 121 ylvgytllav agpfvfiscf qlansfpqrs gtvlalltgs fdsssalfll yrllyqnwfp 181 tlnvsrfftl ylivpvfila cqltimphss yktvnhiaki avegldengr liegdtgsgi 241 ipdeqerqsl iaiereedsi psrpqrrksv letyvedklq kksggifgvl hgksayeqik 301 spwfylmllf alvamlriny fiatvrtqee yllndpdlal klnsifdmll plggavsipf 361 igllldhtdt lstltilftt staigvfgli pnsftwnlig ivllvvyrpf yytvvsdyss 421 kvfgfdtfgt vygllscicg ifnmsqnlld kwthttfnmn pfpinltlvi ltvvfsltlt 481 fyirsqilpk pvnerglssn yqti // LOCUS NP_013949 223 aa linear PLN 30-JUN-2025 DEFINITION putative serine hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013949 VERSION NP_013949.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182729.1 REFERENCE 1 (residues 1 to 223) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 223) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 223) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 223) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10121. Method: conceptual translation. FEATURES Location/Qualifiers source 1..223 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..223 /product="putative serine hydrolase" /calculated_mol_wt="24402" Region 1..214 /region_name="FSH1" /note="Serine hydrolase (FSH1); pfam03959" /db_xref="CDD:461110" CDS 1..223 /gene="FSH2" /locus_tag="YMR222C" /coded_by="NM_001182729.1:1..672" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2" /db_xref="GeneID:855262" /db_xref="SGD:S000004835" ORIGIN 1 mtknvlmlhg laqsgdyfas ktkgfraeme klgyklyypt apnefppadv pdflgeviad 61 apgdgentgv lawlendpst ggyfipqtti dylhnyvlen gpfagivgfs qgagvagyla 121 tdfngllglt teeqppleff mavsgfrfqp qqyqeqydlh pisvpslhvq geldtitepa 181 kvqglynsct edsrtllmhs gghfvpnsrg fvrkvaqwlq qlt // LOCUS NP_013950 471 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease UBP8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013950 VERSION NP_013950.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182730.1 REFERENCE 1 (residues 1 to 471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 471) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10122. Method: conceptual translation. FEATURES Location/Qualifiers source 1..471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..471 /product="ubiquitin-specific protease UBP8" /EC_number="3.4.19.12" /calculated_mol_wt="53492" Region 46..108 /region_name="zf-UBP" /note="Zn-finger in ubiquitin-hydrolases and other protein; pfam02148" /db_xref="CDD:460464" Region 138..466 /region_name="Peptidase_C19D" /note="A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02660" /db_xref="CDD:239125" Site order(141,146,427,444) /site_type="active" /db_xref="CDD:239125" CDS 1..471 /gene="UBP8" /locus_tag="YMR223W" /coded_by="NM_001182730.1:1..1416" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:12052880|PMID:14563679]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:14563679]" /experiment="EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:20434206]" /experiment="EXISTENCE:direct assay:GO:0071819 DUBm complex [PMID:20395473]" /experiment="EXISTENCE:mutant phenotype:GO:0004843 cysteine-type deubiquitinase activity [PMID:14563679]" /experiment="EXISTENCE:mutant phenotype:GO:0008380 RNA splicing [PMID:23209445]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:20434206]" /note="Ubiquitin-specific protease component of the SAGA acetylation complex; required for SAGA (Spt-Ada-Gcn5-Acetyltransferase)-mediated deubiquitination of histone H2B" /db_xref="GeneID:855263" /db_xref="SGD:S000004836" ORIGIN 1 msicphiqqv fqnekskdgv lktcnaaryi lnhsvpkekf lntmkcgtch einsgatfmc 61 lqcgfcgcwn hshflshskq ighifginsn ngllfcfkce dyignidlin dailakywdd 121 vctktmvpsm errdglsgli nmgstcfmss ilqclihnpy firhsmsqih snnckvrspd 181 kcfscaldki vhelygalnt kqasssstst nrqtgfiyll tcawkinqnl agysqqdahe 241 fwqfiinqih qsyvldlpna kevsrannkq cecivhtvfe gslessivcp gcqnnsktti 301 dpfldlsldi kdkkklyecl dsfhkkeqlk dfnyhcgecn stqdaikqlg ihklpsvlvl 361 qlkrfehlln gsnrklddfi efptylnmkn ycstkekdkh sengkvpdii yeligivshk 421 gtvneghyia fckisggqwf kfndsmvssi sqeevlkeqa yllfytirqv n // LOCUS NP_013951 692 aa linear PLN 30-JUN-2025 DEFINITION MRX complex nuclease subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_013951 VERSION NP_013951.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182731.1 REFERENCE 1 (residues 1 to 692) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 692) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 692) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 692) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10123. Method: conceptual translation. FEATURES Location/Qualifiers source 1..692 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..692 /product="MRX complex nuclease subunit" /calculated_mol_wt="77520" Region 6..413 /region_name="mre11" /note="DNA repair protein (mre11); TIGR00583" /db_xref="CDD:273153" CDS 1..692 /gene="MRE11" /locus_tag="YMR224C" /gene_synonym="NGS1; RAD58; XRS4" /coded_by="NM_001182731.1:1..2079" /experiment="EXISTENCE:direct assay:GO:0003691 double-stranded telomeric DNA binding [PMID:17698079]" /experiment="EXISTENCE:direct assay:GO:0004017 AMP kinase activity [PMID:17349953]" /experiment="EXISTENCE:direct assay:GO:0004519 endonuclease activity [PMID:9858579]" /experiment="EXISTENCE:direct assay:GO:0004520 DNA endonuclease activity [PMID:16116037]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9845372|PMID:22842922|PMID:15548595]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0008408 3'-5' exonuclease activity [PMID:11454871]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:15721260|PMID:16116037]" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17698079]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:17698079]" /experiment="EXISTENCE:genetic interaction:GO:0000727 double-strand break repair via break-induced replication [PMID:17321803]" /experiment="EXISTENCE:genetic interaction:GO:0060090 molecular adaptor activity [PMID:9845372]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:17321803]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:7789757]" /experiment="EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:20040573]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380|PMID:9501103]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:17396017]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:8417989]" /experiment="EXISTENCE:mutant phenotype:GO:0010791 DNA double-strand break processing involved in repair via synthesis-dependent strand annealing [PMID:23254329]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:17396017]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:27173583]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:17396017]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:9845372]" /experiment="EXISTENCE:mutant phenotype:GO:0097552 mitochondrial double-strand break repair via homologous recombination [PMID:22214610]" /experiment="EXISTENCE:physical interaction:GO:0030870 Mre11 complex [PMID:9845372]" /note="Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:855264" /db_xref="SGD:S000004837" ORIGIN 1 mdypdpdtir ilittdnhvg ynendpitgd dswktfhevm mlaknnnvdm vvqsgdlfhv 61 nkpskkslyq vlktlrlccm gdkpcelell sdpsqvfhyd eftnvnyedp nfnisipvfg 121 isgnhddasg dsllcpmdil hatglinhfg kviesdkikv vpllfqkgst klalyglaav 181 rderlfrtfk dggvtfevpt mregewfnlm cvhqnhtght ntaflpeqfl pdfldmviwg 241 hehecipnlv hnpiknfdvl qpgssvatsl ceaeaqpkyv fildikygea pkmtpiplet 301 irtfkmksis lqdvphlrph dkdatskyli eqveemirda neetkqklad dgegdmvael 361 pkplirlrvd ysapsntqsp idyqvenprr fsnrfvgrva ngnnvvqfyk krspvtrskk 421 sgingtsisd rdveklfses ggelevqtlv ndllnkmqls llpevglnea vkkfvdkdek 481 talkefishe isnevgilst neeflrtdda eemkalikqv kransvrptp pkendetnfa 541 fngngldsfr ssnrevrtgs pditqshvdn esrithisqa esskptskpk rvrtatkkki 601 pafsdstvis daenelgdnn daqddvdide ndiimvstde edasygllng rktktktrpa 661 astktasrrg kgrasrtpkt dilgsllakk rk // LOCUS NP_013952 98 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL53 MRPL44 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013952 VERSION NP_013952.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182732.1 REFERENCE 1 (residues 1 to 98) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 98) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 98) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 98) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10124. Method: conceptual translation. FEATURES Location/Qualifiers source 1..98 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..98 /product="mitochondrial 54S ribosomal protein mL53 MRPL44" /calculated_mol_wt="11345" Region 13..63 /region_name="MRP_L53" /note="39S ribosomal protein L53/MRP-L53; pfam10780" /db_xref="CDD:463186" CDS 1..98 /gene="MRPL44" /locus_tag="YMR225C" /gene_synonym="mL53; YMR44" /coded_by="NM_001182732.1:1..297" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:2060626]" /note="Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855265" /db_xref="SGD:S000004838" ORIGIN 1 mitkyfskvi vrfnpfgkea kvarlvlaai pptqrnmgtq iqseiisdyn kvkplvkvty 61 kdkkemevdp snmnfqelan hfdrhskqld lkhmlemh // LOCUS NP_013953 267 aa linear PLN 30-JUN-2025 DEFINITION oxidoreductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013953 VERSION NP_013953.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182733.1 REFERENCE 1 (residues 1 to 267) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 267) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 267) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 267) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10125. Method: conceptual translation. FEATURES Location/Qualifiers source 1..267 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..267 /product="oxidoreductase" /EC_number="1.1.1.381" /calculated_mol_wt="29027" Region 14..266 /region_name="SDR_c5" /note="classical (c) SDR, subgroup 5; cd05346" /db_xref="CDD:187604" Site order(20,22..25,47..49,74..76,102..104,126,153..155,168, 172,198..201,203..204) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:187604" Site order(79,111..112,117..118,120..121,124..125,128..129, 132..133,136,139,143,157..167,169..171,173..174,177..178, 181..182,184..185,187..188,266) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:187604" Site order(79,112,117..118,120..121,125,129,133,136,158..161, 163..166,170..171,173..174,177,180..181,183..185,231,238, 245,247,249..266) /site_type="other" /note="homotetramer interface [polypeptide binding]" /db_xref="CDD:187604" Site order(127,155,168,172) /site_type="active" /db_xref="CDD:187604" CDS 1..267 /gene="ORA1" /locus_tag="YMR226C" /coded_by="NM_001182733.1:1..804" /experiment="EXISTENCE:direct assay:GO:0004090 carbonyl reductase (NADPH) activity [PMID:18630881]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016491 oxidoreductase activity [PMID:17962934]" /experiment="EXISTENCE:direct assay:GO:0031132 serine 3-dehydrogenase activity [PMID:12535615]" /experiment="EXISTENCE:direct assay:GO:0045149 acetoin metabolic process [PMID:33845171]" /experiment="EXISTENCE:direct assay:GO:0052588 diacetyl reductase ((S)-acetoin forming) (NAD+) activity [PMID:33845171]" /note="NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; catalyzes the reduction of (S)-alpha-acetolactate to 2,3-dimethylglycerate; short-chain dehydrogenase/reductase (SDR) family member; GFP fusion protein localizes to the cytoplasm and nucleus" /db_xref="GeneID:855266" /db_xref="SGD:S000004839" ORIGIN 1 msqgrkaaer lakktvlitg asagigkata leyleasngd mklilaarrl ekleelkkti 61 dqefpnakvh vaqlditqae kikpfienlp qefkdidilv nnagkalgsd rvgqiatedi 121 qdvfdtnvta linitqavlp ifqaknsgdi vnlgsiagrd ayptgsiyca skfavgaftd 181 slrkelintk irviliapgl vetefslvry rgneeqaknv ykdttplmad dvadlivyat 241 srkqntviad tlifptnqas phhifrg // LOCUS NP_013954 590 aa linear PLN 30-JUN-2025 DEFINITION TATA-binding protein-associated factor TAF7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013954 VERSION NP_013954.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182734.1 REFERENCE 1 (residues 1 to 590) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 590) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 590) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 590) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10126. Method: conceptual translation. FEATURES Location/Qualifiers source 1..590 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..590 /product="TATA-binding protein-associated factor TAF7" /calculated_mol_wt="67425" Region 1..498 /region_name="Taf7" /note="TATA-binding protein-associated factor Taf7, part of the TFIID transcription initiation complex [Transcription]; COG5414" /db_xref="CDD:227701" CDS 1..590 /gene="TAF7" /locus_tag="YMR227C" /gene_synonym="TAF67" /coded_by="NM_001182734.1:1..1773" /experiment="EXISTENCE:curator inference:GO:0016251 RNA polymerase II general transcription initiation factor activity []" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]" /note="TFIID subunit (67 kDa); involved in RNA polymerase II transcription initiation" /db_xref="GeneID:855267" /db_xref="SGD:S000004840" ORIGIN 1 mavirikkpr gpgekdqple gepklkriri ktkvtdedik pkpklkinlk kkkesadgke 61 kknslklkln lkkneepvkk ihkapklrlk piripgeayd seasdieddp liesgvilri 121 lpdiqlefvk nslesgdysg isikwknerh avvtindvmy gailvdlptv ievnksvdrk 181 nllktfdvsq mllcirpiqe eeevyaleap dtedlvvkhf egiedeiwen ketflkgyng 241 aplsdmeakh lkeialkgyd ykhgispply nvrnrrfrrk mdpneidyve kvvdmllkqd 301 kqaeevsydl vdkselqarq ervsswenfk eepgeplsrp alkkeeihti asavgkqgae 361 eegeegmeee eeedldlgaa feseeegsga egdkeqqqee vgdevdqdtg gedddddddg 421 dieaaggese sddekdenrq htelladeln elettlahtk hklskatnpl lksrfidsik 481 klekeaelkr kqlqqtedsv qkqhqhrsda etannveeee eeeeeeeeed evdedeedde 541 endedednvh erehiqenkv vreldeapae etldqndldm mmlfgaegde // LOCUS NP_013955 341 aa linear PLN 30-JUN-2025 DEFINITION RNA polymerase specificity factor [Saccharomyces cerevisiae S288C]. ACCESSION NP_013955 VERSION NP_013955.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182735.1 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10127. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..341 /product="RNA polymerase specificity factor" /calculated_mol_wt="39596" Region 11..316 /region_name="RrnaAD" /note="Ribosomal RNA adenine dimethylase; pfam00398" /db_xref="CDD:395321" CDS 1..341 /gene="MTF1" /locus_tag="YMR228W" /coded_by="NM_001182735.1:1..1026" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:12270918|PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:12270918]" /experiment="EXISTENCE:direct assay:GO:0006391 transcription initiation at mitochondrial promoter [PMID:19920143]" /experiment="EXISTENCE:direct assay:GO:0034245 mitochondrial DNA-directed RNA polymerase complex [PMID:7929382]" /experiment="EXISTENCE:direct assay:GO:0034246 mitochondrial transcription factor activity [PMID:7929382|PMID:20008320]" /experiment="EXISTENCE:mutant phenotype:GO:0032786 positive regulation of DNA-templated transcription, elongation [PMID:31980825]" /experiment="EXISTENCE:physical interaction:GO:0034246 mitochondrial transcription factor activity [PMID:7929382]" /note="Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation" /db_xref="GeneID:855268" /db_xref="SGD:S000004841" ORIGIN 1 msvpipgikd isklkffygf kylwnptvyn kifdkldltk tykhpeelkv ldlypgvgiq 61 saifynkycp rqysllekrs slykflnakf egsplqilkr dpydwstysn lideerifvp 121 evqssdhind kfltvanvtg egseglimqw lscignknwl yrfgkvkmll wmpsttarkl 181 larpgmhsrs kcsvvreaft dtkliaisda nelkgfdsqc ieewdpilfs aaeiwptkgk 241 pialvemdpi dfdfdvdnwd yvtrhlmilk rtplntvmds lghggqqyfn sritdkdllk 301 kcpidltnde fiyltklfme wpfkpdilmd fvdmyqtehs g // LOCUS NP_013956 1729 aa linear PLN 30-JUN-2025 DEFINITION Rrp5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013956 VERSION NP_013956.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182736.1 REFERENCE 1 (residues 1 to 1729) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1729) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1729) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1729) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1729) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1729) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1729) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10128. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1729 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1729 /product="Rrp5p" /calculated_mol_wt="193004" Region 116..246 /region_name="S1_Rrp5_repeat_hs1_sc1" /note="Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in Saccharomyces...; cd05693" /db_xref="CDD:240198" Site order(127,135,145,147) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240198" Region 252..325 /region_name="S1_Rrp5_repeat_hs2_sc2" /note="Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in Saccharomyces...; cd05694" /db_xref="CDD:240199" Site order(264,272,283,285) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240199" Region 337..408 /region_name="S1" /note="Ribosomal protein S1-like RNA-binding domain; smart00316" /db_xref="CDD:197648" Site order(346,354,364,366) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:238094" Region 510..579 /region_name="S1_like" /note="Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. Both domains...; cl09927" /db_xref="CDD:471952" Site order(519,527,538,540) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:238094" Region 607..676 /region_name="S1_Rrp5_repeat_hs6_sc5" /note="Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in Saccharomyces...; cd05698" /db_xref="CDD:240203" Site order(615,623,633,635) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240203" Region <624..779 /region_name="rpsA" /note="30S ribosomal protein S1; Reviewed; PRK06299" /db_xref="CDD:235775" Region 777..862 /region_name="S1_Rrp5_repeat_hs8_sc7" /note="Rrp5 Homo sapiens S1 repeat 8 (hs8) and Saccharomyces cerevisiae S1 repeat 7 (sc7)-like domains. Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal...; cd04461" /db_xref="CDD:239908" Site 820 /site_type="other" /note="oligonucleotide binding site [chemical binding]" /db_xref="CDD:239908" Region 895..967 /region_name="S1_Rrp5_repeat_hs11_sc8" /note="Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in Saccharomyces...; cd05702" /db_xref="CDD:240207" Site order(903,911,921,923) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240207" Region 1003..1071 /region_name="S1_Rrp5_repeat_hs12_sc9" /note="Rrp5 is a trans-acting factor important for biogenesis of both the 40S and 60S eukaryotic ribosomal subunits. Rrp5 has two distinct regions, an N-terminal region containing tandemly repeated S1 RNA-binding domains (12 S1 repeats in Saccharomyces...; cd05703" /db_xref="CDD:240208" Site order(1011,1019,1029,1031) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240208" Region 1081..>1337 /region_name="RpsA" /note="Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; COG0539" /db_xref="CDD:440305" Region 1459..1712 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" CDS 1..1729 /gene="RRP5" /locus_tag="YMR229C" /coded_by="NM_001182736.1:1..5190" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:8896463|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008266 poly(U) RNA binding [PMID:16428605]" /experiment="EXISTENCE:direct assay:GO:0030490 maturation of SSU-rRNA [PMID:23630256]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:24239293]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:24239293]" /experiment="EXISTENCE:direct assay:GO:0034512 box C/D sno(s)RNA binding [PMID:24239293]" /experiment="EXISTENCE:direct assay:GO:0034513 box H/ACA snoRNA binding [PMID:24239293]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:24239293]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8896463]" /experiment="EXISTENCE:mutant phenotype:GO:0000464 endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8896463]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8896463]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8896463]" /experiment="EXISTENCE:mutant phenotype:GO:0034463 90S preribosome assembly [PMID:24239293]" /note="RNA binding protein involved in synthesis of 18S and 5.8S rRNAs; component of ribosomal small subunit (SSU) processome and 90S preribosome; required for pre-rRNA packaging and compaction of processome into dense terminal balls; part of Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription with role in biogenesis of large ribosomal subunit; binds single stranded tracts of U's; relocalizes from nucleolus to nucleus upon DNA replication stress" /db_xref="GeneID:855269" /db_xref="SGD:S000004842" ORIGIN 1 mvastkrkrd edfplsreds tkqpstsslv rnteevsfpr ggasaltple lkqvaneaas 61 dvlfgnesvk asepasrplk kkkttkksts kdseassans dearaglieh vnfktlkngs 121 sllgqisait kqdlcitftd gisgyvnlth iseeftsile dldedmdsdt daadekkskv 181 edaeyessdd edekldksne lpnlrryfhi gqwlrcsvik ntslepstkk skkkrielti 241 epssvniyad edlvkstsiq cavksiedhg atldvglpgf tgfiakkdfg nfekllpgav 301 flgnitkksd rsivvntdfs dkknkitqis sidaiipgqi vdllcesitk ngiagkvfgl 361 vsgvvnvshl rtfseedlkh kfvigssirc riiaclenks gdkvlilsnl philkledal 421 rstegldafp igytfescsi kgrdseylyl aldddrlgkv hssrvgeien senlssrvlg 481 yspvddiyql stdpkylklk ylrtndipig ellpsceits vsssgielki fngqfkasvp 541 plhisdtrlv yperkfkigs kvkgrvisvn srgnvhvtlk kslvniedne lplvstyena 601 knikeknekt latiqvfkpn gciisffggl sgflpnseis evfvkrpeeh lrlgqtvivk 661 lldvdadrrr iiatckvsne qaaqqkdtie nivpgrtiit vhviektkds viveipdvgl 721 rgviyvghls dsrieqnraq lkklrigtel tglvidkdtr trvfnmslks slikdakket 781 lpltyddvkd lnkdvpmhay iksisdkglf vafngkfigl vlpsyavdsr didiskafyi 841 nqsvtvyllr tddknqkfll slkapkvkee kkkvesnied pvdssikswd dlsigsivka 901 kiksvkknql nvilaanlhg rvdiaevfdt yeeitdkkqp lsnykkddvi kvkiignhdv 961 kshkflpith kiskasvlel smkpselksk evhtksleei nigqeltgfv nnssgnhlwl 1021 tispvlkari slldladnds nfseniesvf plgsalqvkv asidrehgfv naigkshvdi 1081 nmstikvgde lpgrvlkiae kyvlldlgnk vtgisfitda lndfsltlke afedkinnvi 1141 pttvlsvdeq nkkielslrp ataktrsiks hedlkqgeiv dgivknvndk gifvylsrkv 1201 eafvpvskls dsylkewkkf ykpmqyvlgk vvtcdedsri sltlresein gdlkvlktys 1261 dikagdvfeg tiksvtdfgv fvkldntvnv tglahiteia dkkpedlsal fgvgdrvkai 1321 vlktnpekkq islslkashf skeaelastt tttttvdqle kededevmad agfndsdses 1381 digdqnteva drkpetssdg lslsagfdwt asildqaqee eesdqdqedf tenkkhkhkr 1441 rkenvvqdkt idintrapes vadferllig npnssvvwmn ymafqlqlse iekarelaer 1501 alktinfree aeklniwiam lnlentfgte etleevfsra cqymdsytih tkllgiyeis 1561 ekfdkaaelf katakkfgge kvsiwvswgd flishneeqe artilgnalk alpkrnhiev 1621 vrkfaqlefa kgdpergrsl feglvadapk ridlwnvyvd qevkakdkkk vedlferiit 1681 kkitrkqakf ffnkwlqfee segdektiey vkakateyva shesqkade // LOCUS NP_013957 105 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS10 RPS10B [Saccharomyces cerevisiae S288C]. ACCESSION NP_013957 VERSION NP_013957.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182737.1 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10129. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..105 /product="40S ribosomal protein eS10 RPS10B" /calculated_mol_wt="12607" Region 1..105 /region_name="COG5045" /note="Ribosomal protein S10E [Translation, ribosomal structure and biogenesis]" /db_xref="CDD:227378" CDS 1..105 /gene="RPS10B" /locus_tag="YMR230W" /coded_by="NM_001182737.1:1..318" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10B has a paralog, RPS10A, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia" /db_xref="GeneID:855270" /db_xref="SGD:S000004843" ORIGIN 1 mlmpkqernk ihqylfqegv vvakkdfnqa kheeidtknl yvikalqslt skgyvktqfs 61 wqyyyytlte egveylreyl nlpehivpgt yiqernpsqr pqrry // LOCUS NP_878146 62 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR230W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878146 VERSION NP_878146.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184573.1 REFERENCE 1 (residues 1 to 62) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 62) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 62) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 62) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10130. Method: conceptual translation. FEATURES Location/Qualifiers source 1..62 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..62 /product="uncharacterized protein" /calculated_mol_wt="7145" CDS 1..62 /locus_tag="YMR230W-A" /coded_by="NM_001184573.1:1..189" /note="hypothetical protein" /db_xref="GeneID:1466504" /db_xref="SGD:S000028576" ORIGIN 1 mciivkysqc nlffqdvlrc rhvlcmlfsi vvhfrlssfv svcgvrimcn cincsrfihn 61 in // LOCUS NP_013958 1029 aa linear PLN 30-JUN-2025 DEFINITION tethering complex subunit PEP5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013958 VERSION NP_013958.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182738.1 REFERENCE 1 (residues 1 to 1029) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1029) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1029) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1029) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1029) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1029) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1029) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10131. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1029 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1029 /product="tethering complex subunit PEP5" /EC_number="2.3.2.27" /calculated_mol_wt="117347" Region 926..975 /region_name="RING-H2_Vps11" /note="RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 11 homolog (Vps11) and similar proteins; cd16688" /db_xref="CDD:438349" Region 976..1021 /region_name="VPS11_C" /note="Vacuolar protein sorting protein 11 C terminal; pfam12451" /db_xref="CDD:463590" CDS 1..1029 /gene="PEP5" /locus_tag="YMR231W" /gene_synonym="END1; VAM1; VPL9; VPS11; VPT11" /coded_by="NM_001182738.1:1..3090" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:10944212]" /experiment="EXISTENCE:direct assay:GO:0033263 CORVET complex [PMID:17488625]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:16601699]" /experiment="EXISTENCE:direct assay:GO:0035542 regulation of SNARE complex assembly [PMID:18385512]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:22570702]" /experiment="EXISTENCE:direct assay:GO:0099022 vesicle tethering [PMID:27307091]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:11422941]" /experiment="EXISTENCE:genetic interaction:GO:0045324 late endosome to vacuole transport [PMID:11422941]" /experiment="EXISTENCE:mutant phenotype:GO:0036205 histone catabolic process [PMID:22570702]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:physical interaction:GO:0030897 HOPS complex [PMID:10944212]" /note="Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitination and degradation of excess histones" /db_xref="GeneID:855271" /db_xref="SGD:S000004844" ORIGIN 1 mslsswrqfq lfenipirdp nfggdsllys dptlcaativ dpqtliiavn sniikvvkln 61 qsqvihefqs fphdfqitfl kvingeflva laesigkpsl irvykleklp nreqlyhsqv 121 elkngnntyp isvvsisndl scivvgfing kiilirgdis rdrgsqqrii yedpskepit 181 alflnndata cfaattsril lfnttgrnrg rpslvlnskn gldlncgsfn patneficcl 241 snfieffsss gkkhqfafdl slrkrifcvd kdhilivtee tgvpttsisv nelsptiinr 301 ifiidaknki islnfvvssa iidifstsqs gknityllts egvmhritpk slenqiniii 361 qkelypfalq lakqhslspl dvqeihkkyg dylfkkglrk eatdqyiqcl dvvetseiis 421 kfgvkevpdp esmrnladyl wsliknsisq rdhvtllliv liklkdvegi dtfiqhfdrk 481 giwnegvvmd dmddvtffys dndffdldli lelmkesdfk rlsyrlakky skdsliivdi 541 llnllhnpvk aikyikslpi detlrclvty skklleespn etnallievf tgkfkpstfe 601 vdldrrdttg dfsenirtvf ysyktffnym nsngtsdams esseashehe eptyhppkps 661 ivfssfvtkp fefvvfleac lacyqqyegf dedrqviltt lydlylnlaq ndvperiddw 721 rsratgvlre snklvysaas nntskrvdns imllishmdq ssasakdktk idiasfandn 781 pemdllstfr amtlneepst clkflekygt eepkllqval syfvsnklif kemggnevlk 841 ekvlrpiieg ermplldiik alsrtnvahf gliqdiiidh vktedteikr nekliesydk 901 elkeknkklk ntinsdqplh vplknqtcfm crltldipvv ffkcghiyhq hclneeedtl 961 eserklfkcp kclvdletsn klfeaqhevv ekndllnfal nseegsrdrf kviteflgrg 1021 aisysditi // LOCUS NP_013959 677 aa linear PLN 30-JUN-2025 DEFINITION Fus2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013959 VERSION NP_013959.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182739.1 REFERENCE 1 (residues 1 to 677) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 677) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 677) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 677) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 677) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 677) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 677) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10132. Method: conceptual translation. FEATURES Location/Qualifiers source 1..677 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..677 /product="Fus2p" /calculated_mol_wt="78906" Region 114..301 /region_name="RhoGEF" /note="Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; cl02571" /db_xref="CDD:470622" Site order(119,123,248,275..276,279..280,282..283,286..287, 290..291,294) /site_type="other" /note="GTPase interaction site [polypeptide binding]" /db_xref="CDD:238091" CDS 1..677 /gene="FUS2" /locus_tag="YMR232W" /coded_by="NM_001182739.1:1..2034" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:18474625]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18474625]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:7559752]" /experiment="EXISTENCE:genetic interaction:GO:0000755 cytogamy [PMID:3302672]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:7559752]" /experiment="EXISTENCE:mutant phenotype:GO:0000747 conjugation with cellular fusion [PMID:22323294]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:7559752|PMID:3302672]" /note="Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specifically with activated Cdc42p" /db_xref="GeneID:855272" /db_xref="SGD:S000004845" ORIGIN 1 mfktsynlyd lnypkndslt pirdykndyf hknddklpei vrkptrklsk henklndkkf 61 tnkrpasldl hsiveslsnk kiyspintei fqnvvrlnls pqipnspheg ckfykivqef 121 ylseveyynn lltannvyrk alnsdprfkn klvkldssde lllfgnidti asiskilvta 181 ikdlllakqr gkmldanewq kiftknevqq qlystfdise afeqhllrik stytsyfvsh 241 qkqmelfttl rmnknhffnk wyeyclkesg cikledilks pmkrltqwid tletlescye 301 dilspelglk lsptrrkysl fsnkletevs eyksnsmynf sltpseiiqs ydedqfthll 361 kppdkqnkni cnasrqesnl dnsrvpslls gsssyysdvs gleivtntst asaeminlkm 421 deetefftla dhiskfkkvm kgllelkknl lkndlsgiid islrrinawk kviecerpsg 481 affahdnlis tmcssyidkl heqknqvtil klteletdvm npleriiahc ttvksklkdl 541 qalkkdymlf lqekkanvrd ikrdllgmhf qnlqnqmkre lpvfitlihd tiecillnyi 601 kvflkyleii aggkkylqkd lenmslndsi atgqiknldi lqcysksrym tkrmvrkdwp 661 fpgdpsgsrv vrklfel // LOCUS NP_013960 226 aa linear PLN 30-JUN-2025 DEFINITION Tri1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013960 VERSION NP_013960.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182740.1 REFERENCE 1 (residues 1 to 226) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 226) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 226) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10133. Method: conceptual translation. FEATURES Location/Qualifiers source 1..226 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..226 /product="Tri1p" /calculated_mol_wt="26340" Region 6..55 /region_name="DEK_C" /note="DEK C terminal domain; pfam08766" /db_xref="CDD:462592" Region 124..193 /region_name="SWIB-MDM2_like" /note="SWIB/MDM2 domain found in SWIB/MDM2 homologous proteins; cd10567" /db_xref="CDD:349489" Site order(142,145..146,148..149,152..153,158,163..164,166, 185..186) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:349489" CDS 1..226 /gene="TRI1" /locus_tag="YMR233W" /coded_by="NM_001182740.1:1..681" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Non-essential sumoylated hypothetical protein; similar to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus; TRI1 has a paralog, UAF30, that arose from the whole genome duplication" /db_xref="GeneID:855273" /db_xref="SGD:S000004846" ORIGIN 1 madinkyipm vdailsvsnp deispkrvrk alqilysvnl dsqrklinel ilerfgdiqe 61 nprvlipknd lisrdqelsl rlqkeeerpl rstrkrkgks eskskrkkkk ndspdsnsis 121 vrkvllsapl qkflgseelp rtqvvkmiwq yikehdlqnp kdrreilcde kmepifgkkm 181 tmfsmnkllt khlfnpdeiv kheeeqkqtp ekeiklenes lpnlsg // LOCUS NP_013961 348 aa linear PLN 30-JUN-2025 DEFINITION RNA-DNA hybrid ribonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_013961 VERSION NP_013961.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182741.1 REFERENCE 1 (residues 1 to 348) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 348) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 348) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 348) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10134. Method: conceptual translation. FEATURES Location/Qualifiers source 1..348 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..348 /product="RNA-DNA hybrid ribonuclease" /EC_number="3.1.26.4" /calculated_mol_wt="39300" Region 7..49 /region_name="Cauli_VI" /note="Caulimovirus viroplasmin; pfam01693" /db_xref="CDD:460297" Region 108..153 /region_name="Cauli_VI" /note="Caulimovirus viroplasmin; pfam01693" /db_xref="CDD:460297" Region 190..345 /region_name="RNase_HI_eukaryote_like" /note="Eukaryotic RNase H is essential and is longer and more complex than their prokaryotic counterparts; cd09280" /db_xref="CDD:260012" Site order(193..196,198..200,230..232,235,264,266..267,288..289, 324,327,342) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260012" CDS 1..348 /gene="RNH1" /locus_tag="YMR234W" /coded_by="NM_001182741.1:1..1047" /experiment="EXISTENCE:direct assay:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:7489497]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006401 RNA catabolic process [PMID:7489497]" /note="Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I." /db_xref="GeneID:855274" /db_xref="SGD:S000004847" ORIGIN 1 marqgnfyav rkgretgiyn twnecknqvd gyggaiykkf nsyeqaksfl gqpnttsnyg 61 ssthaggqvs kphttqkrvh rrnrplhyss ltsssacssl ssantntfys vksnvpnies 121 kifnnwkdcq ayvkhkrgit fkkfedqlaa enfisgmsah dyklmniske sfeskyklss 181 ntmynksmnv ycdgssfgng tsssragyga yfegapeeni sepllsgaqt nnraeieavs 241 ealkkiwekl tnekekvnyq iktdseyvtk llndrymtyd nkkleglpns dlivplvqrf 301 vkvkkyyeln kecfknngkf qiewvkghdg dpgnemadfl akkgasrr // LOCUS NP_013962 407 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein RNA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013962 VERSION NP_013962.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182742.1 REFERENCE 1 (residues 1 to 407) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 407) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 407) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10135. Method: conceptual translation. FEATURES Location/Qualifiers source 1..407 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..407 /product="GTPase-activating protein RNA1" /calculated_mol_wt="45685" Region 36..340 /region_name="PPP1R42" /note="protein phosphatase 1 regulatory subunit 42; cl42388" /db_xref="CDD:455733" Site order(44,47,49,52,54,76,79,81,84,86,110,113,115,118,120, 138,141,143,146,148,175,178,180,183,185,204,207,209,212, 214,233,236,238,241,243,262,265,267,270,272,292,295,297, 300,302,323,326,328,331,333) /site_type="active" /note="Leucine-rich repeats [active]" /db_xref="CDD:238064" Site order(50..51,117,182,211,269,296,298,327) /site_type="other" /note="Substrate binding site [chemical binding]" /db_xref="CDD:238064" Region 110..137 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 138..174 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 175..199 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 204..232 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 233..261 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 262..291 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 292..322 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" CDS 1..407 /gene="RNA1" /locus_tag="YMR235C" /coded_by="NM_001182742.1:1..1224" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:9305944|PMID:7744835|PMID:7657689]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8755533]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:2116418|PMID:8755533]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:7657689]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:9305944]" /experiment="EXISTENCE:genetic interaction:GO:0006409 tRNA export from nucleus [PMID:22008473]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:11739405]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:7657689]" /experiment="EXISTENCE:mutant phenotype:GO:0006404 RNA import into nucleus [PMID:16040803]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:22008473]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:17904525]" /note="GTPase activating protein (GAP) for Gsp1p; involved in nuclear transport" /db_xref="GeneID:855275" /db_xref="SGD:S000004848" ORIGIN 1 matlhfvpqh eeeqvysisg kalklttsdd ikpyleelaa lktctkldls gntigtease 61 alakciaent qvreslvevn fadlytsrlv devvdslkfl lpvllkcphl eivnlsdnaf 121 glrtielled yiahavnikh lilsnngmgp fagerigkal fhlaqnkkaa skpfletfic 181 grnrlengsa vylalglksh seglkvvkly qngirpkgva tlihyglqyl knleildlqd 241 ntftkhasli lakalptwkd slfelnlndc llktagsdev fkvftevkfp nlhvlkfeyn 301 emaqetievs flpamekgnl pelekleing nrldedsdal dllqskfddl evddfeevds 361 edeegedeed ededekleei eterlekell evqvddlaer laeteik // LOCUS NP_013963 157 aa linear PLN 30-JUN-2025 DEFINITION chromatin modification protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_013963 VERSION NP_013963.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182743.1 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10136. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..157 /product="chromatin modification protein" /calculated_mol_wt="17184" Region 1..157 /region_name="TAF9" /note="Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) [Transcription]; COG5094" /db_xref="CDD:227425" CDS 1..157 /gene="TAF9" /locus_tag="YMR236W" /gene_synonym="TAF17" /coded_by="NM_001182743.1:1..474" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:10818000]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:15448131|PMID:10788514]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:10747053]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12840001]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:9844639]" /note="Subunit (17 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3" /db_xref="GeneID:855276" /db_xref="SGD:S000004849" ORIGIN 1 mngggknvln knsvgsvsev gpdstqeetp rdvrllhlll asqsihqyed qvplqlmdfa 61 hrytqgvlkd alvyndyags gnsagsglgv edirlaiaar tqyqfkptap kelmlqlaae 121 rnkkalpqvm gtwgvrlppe kycltakewd ledpksm // LOCUS NP_013964 724 aa linear PLN 30-JUN-2025 DEFINITION exomer complex subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_013964 VERSION NP_013964.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182744.1 REFERENCE 1 (residues 1 to 724) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 724) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 724) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 724) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 724) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10137. Method: conceptual translation. FEATURES Location/Qualifiers source 1..724 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..724 /product="exomer complex subunit" /calculated_mol_wt="81918" Region 85..511 /region_name="ChAPs" /note="ChAPs (Chs5p-Arf1p-binding proteins); pfam09295" /db_xref="CDD:401292" CDS 1..724 /gene="BCH1" /locus_tag="YMR237W" /coded_by="NM_001182744.1:1..2175" /experiment="EXISTENCE:direct assay:GO:0034044 exomer complex [PMID:17000877]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]" /experiment="EXISTENCE:physical interaction:GO:0006031 chitin biosynthetic process [PMID:16498409]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:16498409]" /note="Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; interacts selectively with the activated, GTP-bound form of Arf1p; may interact with ribosomes; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress" /db_xref="GeneID:855277" /db_xref="SGD:S000004850" ORIGIN 1 mlsqtsipev kedvigyalh qrrarvgqfq dlgppdlitl ikslpsssst ttatasandn 61 gatsningqd pttivtelhs hdklkgqigt ffycmgidts dptsitifak kitdlfldtp 121 qiwfgkkkhf hvskisissw nafrkydvni ivhipgtvqt yiinsdgeqs qlpsvaeass 181 grnsqdlnvn miwaetfmsg ivrdimimkd nradgesqnl vetlifnpft sgeledvann 241 fiklfplvye kgvyldapth vlnpsltnny lvetlveivr ltksleacrk mlkklieihp 301 eaviilirvy facdleidav dlineqlnsp ssfladdskt shiqlifkse llsiqsefll 361 dvkrdyklak evameavnca pnefktwyll triyiklndm snallslnac pmsqvkekyv 421 lrriapitsd enlhlplpld asieeissln pmdvqleqks adpnlvnlsa sslkstfqla 481 ykllteivqi tgweqllkyr skifvmedey qgstssidea evrgndiskm rskrlcerwl 541 dnlfmllyed lktytdwqse qlyfdaqnsk yhkltvewel fglcakrlgh lpeaakafqi 601 glsqrfspvc aknllqfyid ehkrirrdsv sanseltssq ilssindids siidlvvkic 661 cwnhrwyief siilidalsv avqdmgitkv hneiasrfsd pvaqliddni lnflknftnd 721 tfdn // LOCUS NP_013965 458 aa linear PLN 30-JUN-2025 DEFINITION putative mannan endo-1,6-alpha-mannosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013965 VERSION NP_013965.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182745.1 REFERENCE 1 (residues 1 to 458) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 458) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 458) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 458) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10138. Method: conceptual translation. FEATURES Location/Qualifiers source 1..458 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..458 /product="putative mannan endo-1,6-alpha-mannosidase" /EC_number="3.2.1.101" /calculated_mol_wt="50410" Region 36..385 /region_name="Glyco_hydro_76" /note="Glycosyl hydrolase family 76; pfam03663" /db_xref="CDD:397638" CDS 1..458 /gene="DFG5" /locus_tag="YMR238W" /coded_by="NM_001182745.1:1..1377" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009272 fungal-type cell wall biogenesis [PMID:12421307]" /experiment="EXISTENCE:genetic interaction:GO:0007117 budding cell bud growth [PMID:15470258]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]" /note="Putative mannosidase; essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p" /db_xref="GeneID:855278" /db_xref="SGD:S000004851" ORIGIN 1 mivnisakmi lsicftflsf fkathamdld ttsktsicda taliqggmld yyegtryggt 61 vgmfqspyyw whageafggm lenwflcend tyqellydal laqtgsnydy ipsnqtmveg 121 nddqgiwgit vmgavernft dpgdgkpgwl amvqavfntm ysrwdsehcg gglrwqiftw 181 nsgynykntv snaclfqiaa rlgrytgntt ylevaeqvfd wlvdvgyvvl ndtanvfdga 241 eidtnctdit kiewtynhgi vlgglaymyn atngtgewet sltkilngak syffkdsimy 301 esacqdygtc ntdqrtfksi fsrmlgltsv mapftrdtid dliktsaeaa akscnggtdg 361 htcglnwqkq tndgyyglge qmsaleviqn llihdrpapy kednggtskg danagmnsst 421 tnvlqnnlni kkgdragaai itavilsvlt ggavwmlf // LOCUS NP_013966 471 aa linear PLN 30-JUN-2025 DEFINITION ribonuclease III [Saccharomyces cerevisiae S288C]. ACCESSION NP_013966 VERSION NP_013966.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182746.1 REFERENCE 1 (residues 1 to 471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 471) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10139. Method: conceptual translation. FEATURES Location/Qualifiers source 1..471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..471 /product="ribonuclease III" /EC_number="3.1.26.3" /calculated_mol_wt="53940" Region 44..147 /region_name="RNase_3_N" /note="Ribonuclease III N-terminal domain; pfam18497" /db_xref="CDD:436545" Region 207..354 /region_name="RIBOc" /note="Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional...; cd00593" /db_xref="CDD:238333" Site order(238..239,242..243,246,249..250,253..254,256..258,268, 327,339) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:238333" Site order(238,241,245,317,320) /site_type="active" /db_xref="CDD:238333" Site order(241,317,320) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:238333" Region 367..436 /region_name="DSRM_RNT1p-like" /note="double-stranded RNA binding motif of Saccharomyces cerevisiae ribonuclease 3 (RNT1p) and similar proteins; cd19876" /db_xref="CDD:380705" Site order(367..369,371..372,375..376,393,398,418..421,424..425) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:380705" CDS 1..471 /gene="RNT1" /locus_tag="YMR239C" /coded_by="NM_001182746.1:1..1416" /experiment="EXISTENCE:direct assay:GO:0004525 ribonuclease III activity [PMID:15766245]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15090619]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15090619]" /experiment="EXISTENCE:direct assay:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:19818713]" /experiment="EXISTENCE:direct assay:GO:0034476 U5 snRNA 3'-end processing [PMID:9334335]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:22576366]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:17991894]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:17991894]" /experiment="EXISTENCE:mutant phenotype:GO:0009303 rRNA transcription [PMID:17991894]" /experiment="EXISTENCE:mutant phenotype:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:19818713]" /experiment="EXISTENCE:mutant phenotype:GO:0034473 U1 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034476 U5 snRNA 3'-end processing [PMID:9334335|PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034963 box C/D sno(s)RNA processing [PMID:23201338]" /experiment="EXISTENCE:mutant phenotype:GO:0034964 box H/ACA sno(s)RNA processing [PMID:23201338]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:22576366]" /note="Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes" /db_xref="GeneID:855280" /db_xref="SGD:S000004852" ORIGIN 1 mgskvagkkk tqndnkldne ngsqqrenin tktllkgnlk isnykylevi qlehavtklv 61 esynkiiels pnlvayneav nnqdrvpvqi lpslsryqlk laaelktlhd lkkdailtei 121 tdyenefdte qkqpilqeis kadmeklekl eqvkrekrek idvnvyenln ekedeeedeg 181 edsydptkag divkatkwpp klpeiqdlai rarvfihkst ikdkvylsgs eminahnerl 241 eflgdsilns vmtliiynkf pdysegqlst lrmnlvsneq ikqwsimynf heklktnfdl 301 kdensnfqng klklyadvfe ayigglmedd prnnlpkirk wlrklakpvi eeatrnqval 361 ektdkldmna krqlysligy aslrlhyvtv kkptavdpns ivecrvgdgt vlgtgvgrni 421 kiagiraaen alrdkkmldf yakqraaipr sesvlkdpsq knkkrkfsdt s // LOCUS NP_013967 436 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit CUS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013967 VERSION NP_013967.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182747.1 REFERENCE 1 (residues 1 to 436) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 436) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 436) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 436) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10140. Method: conceptual translation. FEATURES Location/Qualifiers source 1..436 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..436 /product="U2 snRNP complex subunit CUS1" /calculated_mol_wt="50122" Region 1..436 /region_name="CUS1" /note="Splicing factor 3b, subunit 2 [RNA processing and modification]; COG5182" /db_xref="CDD:227509" CDS 1..436 /gene="CUS1" /locus_tag="YMR240C" /coded_by="NM_001182747.1:1..1311" /experiment="EXISTENCE:direct assay:GO:0000245 spliceosomal complex assembly [PMID:8566755]" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:15565172|PMID:16314500]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16314500]" /note="Protein required for assembly of U2 snRNP into the spliceosome; forms a complex with Hsh49p and Hsh155p" /db_xref="GeneID:855281" /db_xref="SGD:S000004853" ORIGIN 1 martksrkrs gnnqnknasv vnnkaeiaam idarrleqkk kggvtnskgk tnkvvdakle 61 kefkdvlqrf qvqendtpke itkdeknnhv viveknpvmn rkhtaedele dtpsdgieeh 121 lsarkrrkte kpslsqlksq vpypqiiewy dcdarypgll asikctknvi pvpshwqskk 181 eylsgrsllg krpfelpdii kktnieqmrs tlpqsgldgq dekslkeasr arvqpkmgal 241 dldykklhdv ffkiganwkp dhllcfgdvy yenrnlfeet nwkrmvdhkr pgrisqelra 301 imnlpegqlp pwcmkmkdig lptgypdlki aglnwditnl kgdvygkiip nhhsrskkqg 361 rnyfgalisf etpefenske dtqanaengr qddkiddeve hkldhfqedi sevtsaeekl 421 erneeesekq lytvlk // LOCUS NP_013968 314 aa linear PLN 30-JUN-2025 DEFINITION Yhm2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013968 VERSION NP_013968.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182748.1 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10141. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..314 /product="Yhm2p" /calculated_mol_wt="34054" Region 35..94 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 109..192 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 211..305 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..314 /gene="YHM2" /locus_tag="YMR241W" /coded_by="NM_001182748.1:1..945" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:9742088]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:20371607|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006842 tricarboxylic acid transport [PMID:9559855]" /experiment="EXISTENCE:direct assay:GO:0006843 mitochondrial citrate transmembrane transport [PMID:20371607]" /experiment="EXISTENCE:direct assay:GO:0015742 alpha-ketoglutarate transport [PMID:20371607]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:9742088]" /experiment="EXISTENCE:direct assay:GO:0180056 citrate:2-oxoglutarate antiporter activity [PMID:20371607]" /experiment="EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:9742088]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:9742088]" /note="Citrate and oxoglutarate carrier protein; exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome" /db_xref="GeneID:855282" /db_xref="SGD:S000004854" ORIGIN 1 mpsttntaaa nviekkpvsf snillgacln lsevttlgqp levvkttmaa nrnftflesv 61 khvwsrggil gyyqglipwa wieastkgav llfvsaeaey rfkslglnnf asgilggvtg 121 gvtqayltmg fctcmktvei trhksasagg vpqsswsvfk niykkegirg inkgvnavai 181 rqmtnwgsrf glsrlvedgi rkitgktnkd dklnpfekig asalggglsa wnqpievirv 241 emqskkedpn rpknltvgkt fkyiyqsngl kglyrgvtpr iglgiwqtvf mvgfgdmake 301 fvarmtgetp vakh // LOCUS NP_013969 172 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL20 RPL20A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013969 VERSION NP_013969.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182749.1 REFERENCE 1 (residues 1 to 172) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 172) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 172) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 172) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10142. On Jul 30, 2007 this sequence version replaced NP_013969.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..172 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..172 /product="60S ribosomal protein eL20 RPL20A" /calculated_mol_wt="20306" Region 80..127 /region_name="Ribosomal_L18A" /note="Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A; pfam01775" /db_xref="CDD:396369" CDS 1..172 /gene="RPL20A" /locus_tag="YMR242C" /gene_synonym="RPL18A2" /coded_by="NM_001182749.1:1..519" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:23874617]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:23874617]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:23874617]" /note="Ribosomal 60S subunit protein L20A; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20A has a paralog, RPL20B, that arose from the whole genome duplication" /db_xref="GeneID:855283" /db_xref="SGD:S000004855" ORIGIN 1 mahfkeyqvi grrlptesvp epklfrmrif asneviaksr ywyflqklhk vkkasgeivs 61 inqineahpt kvknfgvwvr ydsrsgthnm ykeirdvsrv aavetlyqdm aarhrarfrs 121 ihilkvaeie ktadvkrqyv kqfltkdlkf plphrvqkst ktfsykrpst fy // LOCUS NP_878147 29 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR242W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878147 VERSION NP_878147.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184616.1 REFERENCE 1 (residues 1 to 29) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 29) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 29) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 29) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 29) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10143. Method: conceptual translation. FEATURES Location/Qualifiers source 1..29 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..29 /product="uncharacterized protein" /calculated_mol_wt="2969" CDS 1..29 /locus_tag="YMR242W-A" /coded_by="NM_001184616.1:1..90" /note="hypothetical protein" /db_xref="GeneID:1466505" /db_xref="SGD:S000028694" ORIGIN 1 mfkmkfgdtl prsdfgtggn kqapglelg // LOCUS NP_013970 442 aa linear PLN 30-JUN-2025 DEFINITION Zn(2+) transporter ZRC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013970 VERSION NP_013970.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182750.1 REFERENCE 1 (residues 1 to 442) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 442) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 442) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 442) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 442) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10144. Method: conceptual translation. FEATURES Location/Qualifiers source 1..442 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..442 /product="Zn(2+) transporter ZRC1" /calculated_mol_wt="48214" Region 4..372 /region_name="CzcD" /note="Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; COG1230" /db_xref="CDD:440843" CDS 1..442 /gene="ZRC1" /locus_tag="YMR243C" /gene_synonym="OSR1" /coded_by="NM_001182750.1:1..1329" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:9712830]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:mutant phenotype:GO:0005385 zinc ion transmembrane transporter activity [PMID:2693940]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:10856230]" /note="Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication" /db_xref="GeneID:855284" /db_xref="SGD:S000004856" ORIGIN 1 mitgkelrii slltldtvff lleitigyms hslaliadsf hmlndiisll valwavdvak 61 nrgpdakyty gwkraeilga linavflial cfsimiealq rliepqeiqn prlvlyvgva 121 glisnvvglf lfhdhgsdsl hshshgsves gnndldiesn athshshasl pndnlaided 181 aisspgpsgq igevlpqsvv nrlsnesqpl lnhddhdhsh eskkpghrsl nmhgvflhvl 241 gdalgnigvi aaalfiwkte yswryysdpi vsliitiiif ssalplsrra srillqatps 301 tisadqiqre ilavpgviav hdfhvwnlte siyiasihvq idcapdkfms saklirkifh 361 qhgihsatvq pefvsgdvne dirrrfsiia ggspsssqea fdshgntehg rkkrsptayg 421 attassnciv ddavncntsn cl // LOCUS NP_013971 355 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR244W [Saccharomyces cerevisiae S288C]. ACCESSION NP_013971 VERSION NP_013971.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182752.1 REFERENCE 1 (residues 1 to 355) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 355) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 355) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 355) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 355) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10145. Method: conceptual translation. FEATURES Location/Qualifiers source 1..355 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..355 /product="uncharacterized protein" /calculated_mol_wt="37252" Region 46..280 /region_name="SUN" /note="Beta-glucosidase (SUN family); pfam03856" /db_xref="CDD:427547" CDS 1..355 /locus_tag="YMR244W" /coded_by="NM_001182752.1:1..1068" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole" /db_xref="GeneID:855285" /db_xref="SGD:S000004858" ORIGIN 1 mvlcklltpy fllsilsvgv ftataapsps iqmtentnqd hhehakrggt cafpnydgmv 61 avqkggsngg wamspdqecs ygswcpyack pgqlmgqwdp sattysypkc qngglycdsn 121 gnlqkpnsdk dycydgkgtv iaknnansgd vafcqtvlpg neamliptlv gsgskqtlav 181 pgtdywassa shyyvnapgv svedacqwgs sanpqgnwap fvagsnmddn qntfvkigwn 241 pvylesscpf knvkpsfgir itcddesqce glpcsidpss ngvnevtssg ggssgagggn 301 fcvvtarnga kanievfdvg sgssskgkre lnpldvittt vtetkyktvt vtakt // LOCUS NP_013972 104 aa linear PLN 30-JUN-2025 DEFINITION Coa6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013972 VERSION NP_013972.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182751.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10146. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..104 /product="Coa6p" /calculated_mol_wt="12314" Region 15..91 /region_name="COX6B" /note="Cytochrome oxidase c subunit VIb; pfam02297" /db_xref="CDD:426708" CDS 1..104 /gene="COA6" /locus_tag="YMR244C-A" /coded_by="NM_001182751.1:1..315" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:25959673]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:24549041]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:22984289|PMID:24549041]" /note="Protein involved in cytochrome c oxidase (Complex IV) assembly; involved in delivery of copper to Complex IV; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; ortholog implicated in cardiac defects in zebrafish and human; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855287" /db_xref="SGD:S000004857" ORIGIN 1 mglfsfdggk kesqppntrs qrklcwesrd affqcldkad ildamdpkns ksikshckve 61 nekfeencah swikyfkekr vidfkreqti krieqeakqr ernq // LOCUS NP_013974 694 aa linear PLN 30-JUN-2025 DEFINITION long-chain fatty acid-CoA ligase FAA4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013974 VERSION NP_013974.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182754.1 REFERENCE 1 (residues 1 to 694) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 694) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 694) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 694) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10147. Method: conceptual translation. FEATURES Location/Qualifiers source 1..694 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..694 /product="long-chain fatty acid-CoA ligase FAA4" /EC_number="6.2.1.3" /calculated_mol_wt="77136" Region 96..678 /region_name="LC_FACS_euk1" /note="Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; cd17639" /db_xref="CDD:341294" Region <230..>285 /region_name="PRK04319" /note="acetyl-CoA synthetase; Provisional" /db_xref="CDD:235279" Site order(267,270..275,277..278) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341294" Site order(270,393..394,450..455,534,546,549,561,670) /site_type="other" /note="putative AMP binding site [chemical binding]" /db_xref="CDD:341294" Site order(270,312..313,364,366..367,370,393..394,450..455,534, 546,549,558..561,647) /site_type="active" /note="putative active site [active]" /db_xref="CDD:341294" Site order(312,366..367,370,393,558..560,645,647) /site_type="other" /note="putative CoA binding site [chemical binding]" /db_xref="CDD:341294" CDS 1..694 /gene="FAA4" /locus_tag="YMR246W" /coded_by="NM_001182754.1:1..2085" /experiment="EXISTENCE:direct assay:GO:0004467 long-chain fatty acid-CoA ligase activity [PMID:7650027]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:34161133|PMID:24868093|PMID:10515935]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27136724]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0004467 long-chain fatty acid-CoA ligase activity [PMID:22633490|PMID:11477098]" /experiment="EXISTENCE:genetic interaction:GO:0035336 long-chain fatty-acyl-CoA metabolic process [PMID:11477098]" /experiment="EXISTENCE:genetic interaction:GO:0044539 long-chain fatty acid import into cell [PMID:12601005|PMID:27136724]" /experiment="EXISTENCE:genetic interaction:GO:1905329 sphingoid long-chain base transport [PMID:27136724]" /experiment="EXISTENCE:mutant phenotype:GO:0004467 long-chain fatty acid-CoA ligase activity [PMID:11477098]" /experiment="EXISTENCE:mutant phenotype:GO:0035336 long-chain fatty-acyl-CoA metabolic process [PMID:11477098]" /note="Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; role in stationary phase survival; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms cytoplasmic foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4" /db_xref="GeneID:855288" /db_xref="SGD:S000004860" ORIGIN 1 mteqysvavg eaanehetap rrnirvkdqp lirpinssas tlyefalecf tkggkrdgma 61 wrdiidihet kktivkrvdg kdkpiektwl yyeltpyitm tyeemicvmh digrglikig 121 vkpngenkfh ifastshkwm ktflgcmsqg ipvvtaydtl gesglihsmv etdsvaiftd 181 nqllsklavp lktaknvkfv ihnepidpsd krqngklyka akdavdkike vrpdikiysf 241 deiieigkka kdevelhfpk pedpacimyt sgstgtpkgv vlthynivag iggvghnvig 301 wigptdriia flplahifel tfefeafywn gilgyanvkt ltptstrncq gdlmefkptv 361 mvgvaavwet vrkgilakin elpgwsqtlf wtvyalkern ipcsgllsgl ifkrireatg 421 gnlrfilngg saisidaqkf lsnllcpmli gygltegvan acvlepehfd ygiagdlvgt 481 itaklvdved lgyfaknnqg ellfkgapic seyyknpeet aaaftddgwf rtgdiaewtp 541 kgqvkiidrk knlvktlnge yialeklesi yrsnpyvqni cvyadenkvk pvgivvpnlg 601 hlsklaielg imvpgedves yihekklqda vckdmlstak sqglngiell cgivffeeew 661 tpenglvtsa qklkrrdila avkpdvervy kent // LOCUS NP_013975 1562 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein ligase RKR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013975 VERSION NP_013975.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182755.1 REFERENCE 1 (residues 1 to 1562) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1562) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1562) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1562) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10148. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1562 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1562 /product="ubiquitin-protein ligase RKR1" /EC_number="2.3.2.27" /calculated_mol_wt="180056" Region 1..1561 /region_name="COG5219" /note="Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]" /db_xref="CDD:227544" CDS 1..1562 /gene="RKR1" /locus_tag="YMR247C" /gene_synonym="LTN1" /coded_by="NM_001182755.1:1..4689" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:17283062]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17283062]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:17283062]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:27385828]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:25554787]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:27385828]" /experiment="EXISTENCE:direct assay:GO:0072344 rescue of stalled ribosome [PMID:27385828|PMID:27129255|PMID:31189955]" /experiment="EXISTENCE:direct assay:GO:1990112 RQC complex [PMID:23178123]" /experiment="EXISTENCE:direct assay:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:27385828|PMID:27129255]" /experiment="EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:17283062]" /experiment="EXISTENCE:genetic interaction:GO:0010498 proteasomal protein catabolic process [PMID:24261871]" /experiment="EXISTENCE:genetic interaction:GO:0030163 protein catabolic process [PMID:27481473]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:20835226]" /experiment="EXISTENCE:mutant phenotype:GO:0010498 proteasomal protein catabolic process [PMID:24261871]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:20835226]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:27481473]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:17283062]" /experiment="EXISTENCE:mutant phenotype:GO:0072344 rescue of stalled ribosome [PMID:26943317]" /experiment="EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23358411|PMID:23479637]" /experiment="EXISTENCE:physical interaction:GO:1990112 RQC complex [PMID:23479637]" /note="RING domain E3 ubiquitin (Ub) ligase; role in Ub-mediated degradation of non-stop proteins and translationally stalled ER membrane proteins; component of ribosome-bound RQC (ribosome quality control) complex; role in the turnover of stalled nascent chain polypeptides through lysine residues exposed by CAT (C-terminal alanine and threonine) tailing; degrades mRNA products lacking a termination codon; role in chromatin modification; mutations in mouse homolog Listerin elicit neurodegeneration" /db_xref="GeneID:855289" /db_xref="SGD:S000004861" ORIGIN 1 msfggintfq qyntdlglgh ngvrislnyf dglpdpslln slysnelkli fksllkrdet 61 tkekalmdls nlisdfnqne yffndifllc wsqiyaklii sdykvirlqs hqitimlvks 121 lrkkiskflk dfiplillgt celdysvskp slneltecfn kdpakinalw avfqeqllnl 181 vkeivvnene dtisderyss keesefryhr viasavllli klfvhnkdvs ernssslkvi 241 lsdesiwkll nlkngqntna yetvlrlidv lytrgympsh knimklavkk llkslthits 301 knilkvcpvl psilnllatl ddyedgtiws ydksskekvl kflsvsrtsp spgffnavfa 361 lysstkrhsf ldyylewlpf wqksvqrlne kgfsarnsae vlnefwtnfl kfaedsseer 421 vkkmveseif nslscgksls eytklnqtls gvfppdkwer eiedyftsde dirkikvsfe 481 knlfallvts pnnesaisrl fdffvqliet dpsnvfnkyd gvydalnyfl dsdmiflngk 541 igkfineipt lvqestyqnf agimaqysns kffkmntdai tsledffiva lsfnlpktii 601 latmneldnd iyqqlmksds lelelyiedf mknykfddsg eifkgnnkfl nqrtittlyr 661 savangqveq fcavlsklde tffstlllnt dflscalyev sedtneklfk lslqlakgns 721 eianklaqvi lqhaqvyfsp gakekyvtha velingcndt sqiffpanai evfarympai 781 dyrsslvssl stnthllltd dkpinlknmq kliryalfld alldalperv nnhivafitv 841 vselvtdync lseepndlyy dfghtffkhg kvnlnfsdiv gnviqpangg damltfdiae 901 snsvyffyys rvlykvllns idtvssttln gllasvesfv tktvrdqkst dkdyllcail 961 llmfnrsnsk deitklrtll asqligirev elvdqefksl allnnlldip qadkqfvpia 1021 pqrlnmifrs ilkwldsdla yepsfstvrl llldfftklm rfegvrdmgi tafelserll 1081 adslsmcqid dtlyllelrs sclnlyetls qgvskngeei seygdeiqen lielmflnfn 1141 qernnqvstl fyqklykvis smelkklesq ykrifevvln dkdigsninq srllttllgs 1201 lvvktqqdii ieyelriqkq tgsdvdgsas dndvnskfkl pqkllqkvtd evpkeyleye 1261 nknsfikylw ywhlilmyfk dtsynmrqif ieqlkeagli nrmfdfitdq idlrdtefwk 1321 qvdtkeisey nivgnnfspy kedifeeckk llghtlyqlf nnvgcltsiw wlnikdrtlq 1381 ndiekfvsef ispiliknef ddinskmdrl tsnddaltik lnnitnevka syliddqkle 1441 isfklpknyp ltniqvngvs rvgiseqkwk qwimstqhvi tgmngsvlds lelftknvhl 1501 qfsgfeecai cysilhavdr klpsktcptc knkfhgacly kwfrssgnnt cplcrseipf 1561 rr // LOCUS NP_878148 47 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR247W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878148 VERSION NP_878148.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184661.1 REFERENCE 1 (residues 1 to 47) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 47) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 47) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 47) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 47) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 47) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 47) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10149. Method: conceptual translation. FEATURES Location/Qualifiers source 1..47 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..47 /product="uncharacterized protein" /calculated_mol_wt="5021" CDS 1..47 /locus_tag="YMR247W-A" /coded_by="NM_001184661.1:1..144" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole" /db_xref="GeneID:1466506" /db_xref="SGD:S000028849" ORIGIN 1 mahkcasakl lsgimallfn gksllrpicl hvhnhlvsns dtnivwp // LOCUS NP_013976 585 aa linear PLN 30-JUN-2025 DEFINITION glutamate decarboxylase GAD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013976 VERSION NP_013976.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182756.1 REFERENCE 1 (residues 1 to 585) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 585) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 585) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 585) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 585) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10150. Method: conceptual translation. FEATURES Location/Qualifiers source 1..585 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..585 /product="glutamate decarboxylase GAD1" /EC_number="4.1.1.15" /calculated_mol_wt="65859" Region 41..522 /region_name="Glu-decarb-GAD" /note="glutamate decarboxylase; TIGR01788" /db_xref="CDD:130848" Site order(154..155,158,238,277,280,315,318) /site_type="other" /note="pyridoxal 5'-phosphate binding pocket [chemical binding]" /db_xref="CDD:99743" Site 318 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99743" CDS 1..585 /gene="GAD1" /locus_tag="YMR250W" /coded_by="NM_001182756.1:1..1758" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0004351 glutamate decarboxylase activity [PMID:11031268]" /experiment="EXISTENCE:mutant phenotype:GO:0006538 L-glutamate catabolic process [PMID:11031268]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11031268]" /note="Glutamate decarboxylase; converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress" /db_xref="GeneID:855291" /db_xref="SGD:S000004862" ORIGIN 1 mlhrhgskqk nfeniagkvv hdlaglqlls ndvqksavqs ghqgsnnmrd tssqgmanky 61 svpkkglpad lsyqlihnel tldgnphlnl asfvntfttd qarklidenl tknladndey 121 pqlieltqrc ismlaqlwha npdeepigca ttgsseaiml gglamkkrwe hrmknagkda 181 skpniimssa cqvalekftr yfevecrlvp vshrshhmld peslwdyvde ntigcfvilg 241 ttytghlenv ekvadvlsqi eakhpdwsnt dipihadgas ggfiipfgfe kehmkaygme 301 rwgfnhprvv smntsghkfg lttpglgwvl wrdesllade lrfklkylgg veetfglnfs 361 rpgfqvvhqy fnfvslghsg yrtqfqnslf varafsfell nssklpgcfe ivssihesie 421 ndsapksvkd ywehpqaykp gvplvafkls kkfheeypev pqailssllr grgwiipnyp 481 lpkatdgsde kevlrvvfrs emkldlaqll ivdiesiltk lihsyekvch hielaseqtp 541 erkssfiyem llalaspqdd iptpdeiekk nklketttrn yrgtc // LOCUS NP_013977 366 aa linear PLN 30-JUN-2025 DEFINITION omega-class glutathione transferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013977 VERSION NP_013977.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182757.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10151. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..366 /product="omega-class glutathione transferase" /EC_number="2.5.1.18" /calculated_mol_wt="42272" Region 6..362 /region_name="ECM4" /note="Glutathionyl-hydroquinone reductase [Energy production and conversion]; COG0435" /db_xref="CDD:440204" CDS 1..366 /gene="GTO3" /locus_tag="YMR251W" /coded_by="NM_001182757.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0004364 glutathione transferase activity [PMID:16709151]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16936141]" /note="Omega class glutathione transferase; putative cytosolic localization" /db_xref="GeneID:855292" /db_xref="SGD:S000004863" ORIGIN 1 mseksasnnk aefkrqsspf reiisadhpi ykpakgrywl yvalpcpwaq rtlitralkg 61 lapiigcsva hwhlddkgwr fleegdgktn erhwfdiagg issvnlntst pvanipnnah 121 rllvdgtdep hygykrlsdf yfktkpdykg rftvpvlwdl etctivnnes sdiigimnsa 181 afdefvgeey rqvrlvprsl eaqitefnsw vydkinngvy kagfaecaev yerevtslfq 241 yldklenlld kkytdleaey gknnkdkild ryfaigdtlt eadvrlypti vrfdvvyhqh 301 fkcnlatird dysrihtwlk niywrheafq rttdfthikl gytrsqprvn pigitplgpk 361 pdirpp // LOCUS NP_013978 59 aa linear PLN 30-JUN-2025 DEFINITION Hor7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013978 VERSION NP_013978.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182758.1 REFERENCE 1 (residues 1 to 59) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 59) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 59) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 59) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 59) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10152. Method: conceptual translation. FEATURES Location/Qualifiers source 1..59 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..59 /product="Hor7p" /calculated_mol_wt="5442" CDS 1..59 /gene="HOR7" /locus_tag="YMR251W-A" /coded_by="NM_001182758.1:1..180" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15208314]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0007009 plasma membrane organization [PMID:15208314]" /note="hypothetical protein; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication" /db_xref="GeneID:855293" /db_xref="SGD:S000004864" ORIGIN 1 mklsqvvvsa vaftglvsaa nssnsssskn aaqpiaglnn gkvagaagva lagalafli // LOCUS NP_013979 134 aa linear PLN 30-JUN-2025 DEFINITION Mlo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013979 VERSION NP_013979.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182759.1 REFERENCE 1 (residues 1 to 134) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 134) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 134) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 134) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10153. Method: conceptual translation. FEATURES Location/Qualifiers source 1..134 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..134 /product="Mlo1p" /calculated_mol_wt="15504" CDS 1..134 /gene="MLO1" /locus_tag="YMR252C" /coded_by="NM_001182759.1:1..405" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Mitochondrial hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; MLO1 is not an essential gene" /db_xref="GeneID:855294" /db_xref="SGD:S000004865" ORIGIN 1 mfgkvfvsyi rtrigfkpls tiytpvssss lsfdkeacfp fkkwhelnms qkqefiqrfv 61 knyrhqypss ktnvslkgls igmdehndsp svfgifyndi wksfkneqlg tnndnmksgs 121 rfshpsfkql liqk // LOCUS NP_013980 414 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR253C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013980 VERSION NP_013980.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182760.1 REFERENCE 1 (residues 1 to 414) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 414) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 414) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 414) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10154. Method: conceptual translation. FEATURES Location/Qualifiers source 1..414 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..414 /product="uncharacterized protein" /calculated_mol_wt="46528" Region 67..379 /region_name="RhaT" /note="Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]; COG0697" /db_xref="CDD:440461" CDS 1..414 /locus_tag="YMR253C" /coded_by="NM_001182760.1:1..1245" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative membrane protein, involved in salt tolerance; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene" /db_xref="GeneID:855295" /db_xref="SGD:S000004866" ORIGIN 1 mnpsvpkvmk rennthllvs kemndtslql psttrslspk esnsnedfnv dgnettlqri 61 skdylkpnig lvlltvsyff nsamvvstkv lendpddian drqikplqil lvrmvityig 121 tliymyinks tisdvpfgkp evrkwlvlrg ctgffgvfgm yyslmyltis davlitflap 181 sltiflswvi lrerftkvea lgslisllgv vlivrpsflf gtpeltdsss qivessdpks 241 rliatlvglw gvlgmscvyi iiryigkrah aimsvsyfsl itaivsfigi ntipsmkfqi 301 phskkqwilf gnlgvsgfif qllltmgiqr eragrgslmt ytqllyavfw dvalykhwpn 361 iwswigmiii isatlwviri raannettak dltpiiddee nsipltefdl sdsk // LOCUS NP_001335809 102 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR254C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335809 VERSION NP_001335809.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348870.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80329. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..102 /product="uncharacterized protein" /calculated_mol_wt="11685" CDS 1..102 /locus_tag="YMR254C" /coded_by="NM_001348870.1:1..309" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:855296" /db_xref="SGD:S000004867" ORIGIN 1 mvplillill fskfstflrp vnhvlvtkyt aivntkwqtt psiidvtytm hvfymtiili 61 lvrkqmqsih aflgslclps hvldfsivrd ilswyfletv av // LOCUS NP_013982 188 aa linear PLN 30-JUN-2025 DEFINITION Gfd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013982 VERSION NP_013982.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182762.1 REFERENCE 1 (residues 1 to 188) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 188) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 188) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 188) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10155. Method: conceptual translation. FEATURES Location/Qualifiers source 1..188 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..188 /product="Gfd1p" /calculated_mol_wt="21440" Region 129..172 /region_name="GFD1" /note="GFD1 mRNA transport factor; pfam17331" /db_xref="CDD:435870" CDS 1..188 /gene="GFD1" /locus_tag="YMR255W" /coded_by="NM_001182762.1:1..567" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10523319]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:10610322]" /experiment="EXISTENCE:genetic interaction:GO:0006406 mRNA export from nucleus [PMID:10610322|PMID:10523319]" /note="Coiled-coiled hypothetical protein; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855297" /db_xref="SGD:S000004868" ORIGIN 1 mplesiwada pdeepikkqk pshkrsnnnk knnnsrwsne sssnnkkkds vnkvknnkgn 61 hesktknkik etlprekkpp hsqgkispvs eslainpfsq kateispppv spskmkttkt 121 qskqdtaskm kllkkkieeq reilqkthhk nqqqqvlmdf lndegssnwv dddeeelilq 181 rlktslki // LOCUS NP_013983 60 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c oxidase subunit VII [Saccharomyces cerevisiae S288C]. ACCESSION NP_013983 VERSION NP_013983.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182763.1 REFERENCE 1 (residues 1 to 60) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 60) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 60) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 60) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10156. Method: conceptual translation. FEATURES Location/Qualifiers source 1..60 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..60 /product="cytochrome c oxidase subunit VII" /calculated_mol_wt="6801" Region 3..54 /region_name="COX7a" /note="Cytochrome c oxidase subunit VII; pfam02238" /db_xref="CDD:426673" CDS 1..60 /gene="COX7" /locus_tag="YMR256C" /coded_by="NM_001182763.1:1..183" /experiment="EXISTENCE:direct assay:GO:0004129 cytochrome-c oxidase activity [PMID:7851399|PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0045277 respiratory chain complex IV [PMID:1331058]" /note="Subunit VII of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain" /db_xref="GeneID:855298" /db_xref="SGD:S000004869" ORIGIN 1 mankviqlqk ifqsstkplw wrhprsalyl ypfyaifava vvtpllyipn airgikakka // LOCUS NP_013984 800 aa linear PLN 30-JUN-2025 DEFINITION Pet111p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013984 VERSION NP_013984.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182764.1 REFERENCE 1 (residues 1 to 800) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 800) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 800) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 800) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10157. Method: conceptual translation. FEATURES Location/Qualifiers source 1..800 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..800 /product="Pet111p" /calculated_mol_wt="94392" CDS 1..800 /gene="PET111" /locus_tag="YMR257C" /coded_by="NM_001182764.1:1..2403" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11106667]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:3034718]" /experiment="EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:3034718]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:3034718]" /note="Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane" /db_xref="GeneID:855299" /db_xref="SGD:S000004870" ORIGIN 1 mlqrrfisss gikrllhres nkvmhtvffk vryystelik kkhkediedw vkaqlkdsst 61 isgvyesrnk ldwmdsitks pssldilknq ynivkdkdfg ilwkqkfesa dpdilmtiis 121 lstnqkvlfs iqqllilins lhflkrdydi gqiyttyeqf tpllashtdk gtygqfieim 181 lvvqhnlhhf dvcetlfaey ikyckvkpqm islglnsfir snntqlavef ytqaitnpdt 241 fpitekqlfe flrcmeryld mssmkhifyl wlkvkcgdeq ssstnlpsfk tlaiihrmll 301 rfsntdelnd fltnpvvlst gytssvqfel iefchslyci kgdrtksidd silmervdkf 361 itrlnnnist rkelymsvvq ayvstnnfen lkvilekiqr dndisidgsf hlcisryfvn 421 tnqfeglfky yrsvvkttdg ktrlrpafiq qlwscavnvy pmlakeitnd llvtlkrsqy 481 skcltwvytf lqenahihtr kinggedssl sgfnavdfer feefkkkvsh ndvygaelvi 541 snslkegiap qfsflysvla lclrnsltgl arvvdvilrt rfryiplkvd ilwlkweiis 601 nyrsfeklsa ehlkelefkl kefervhqke lsvqnylqlt qicfhtrdfk yacylisqar 661 knldtsnnkq wmmyymtslk lasrmheser fsrilkdwnc nhraslitpg cirqikgfmk 721 yfekrpayis taasidnkei kdridelvlr yvdykyqgle nmrkltlflk ewfdeeisll 781 kleqnerkmk lfeenkkeee // LOCUS NP_013985 553 aa linear PLN 30-JUN-2025 DEFINITION Roy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013985 VERSION NP_013985.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182765.1 REFERENCE 1 (residues 1 to 553) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 553) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 553) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 553) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 553) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10158. Method: conceptual translation. FEATURES Location/Qualifiers source 1..553 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..553 /product="Roy1p" /calculated_mol_wt="64274" CDS 1..553 /gene="ROY1" /locus_tag="YMR258C" /coded_by="NM_001182765.1:1..1662" /experiment="EXISTENCE:direct assay:GO:0005095 GTPase inhibitor activity [PMID:21389113]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006623 protein targeting to vacuole [PMID:21389113]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:21389113]" /note="GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p" /db_xref="GeneID:855300" /db_xref="SGD:S000004871" ORIGIN 1 mafqdqdifi vfshaslfln qndllslslt skkmhdmiai prlysnihit knpvlrtnkw 61 fldggktyvs gyrsvlktgd kndiflydri erlletshlk cikqltided lfhnreeglq 121 llqrlvneit dldviesldi kdptlfelcs akyyrlsslk krvvygetgf dgiklwqnfk 181 slkwqlpesl dlqnviipev gvmlmkqlng geleikdeay sslrvfeyfd slnlrfknlr 241 rlklnhvhkq gdgsatsmrl ssrafkdvvn lsnlkalele fscevddcec dddflqditg 301 nlvsltslgf iektftkkgy hymdekwdlv vnkfilnlpn vskdlrllsi rhdpplngkg 361 idtvdgnllr rkklyekvlp kltsletiia ptvlqsitsy emyacdllwn gckcafcsky 421 lplfdkyimn hqyfstpdar yldiipivfa aytgkslakr fdpqknwdld llqyapedtt 481 wnfhgferih hfasyecyfd essfeplati ishffypymn ylikilpnlr qtmlsgiyfs 541 vspelhtyet iyd // LOCUS NP_013986 1420 aa linear PLN 30-JUN-2025 DEFINITION tRNA methylation protein TRM732 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013986 VERSION NP_013986.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182766.1 REFERENCE 1 (residues 1 to 1420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1420) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10159. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1420 /product="tRNA methylation protein TRM732" /calculated_mol_wt="163447" Region 1..1419 /region_name="COG5543" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227830" Region 1154..1178 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1189..1218 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 1224..1250 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..1420 /gene="TRM732" /locus_tag="YMR259C" /coded_by="NM_001182766.1:1..4263" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0002130 wobble position ribose methylation [PMID:22912484]" /experiment="EXISTENCE:physical interaction:GO:0002130 wobble position ribose methylation [PMID:22912484]" /note="Protein involved in 2'-O-methylation of C32 of substrate tRNAs; interacts with 2'-O-ribose methyltransferase Trm7p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; non-essential gene; yeast null mutant can be functionally complemented by human THADA, mutations in which have been implicated in epithelial thyroid adenomas, type 2 diabetes, and polycystic ovary syndrome (PCOS)" /db_xref="GeneID:855301" /db_xref="SGD:S000004872" ORIGIN 1 mttdvqfssq eielfrvkef liannpakin nenkdavltq iehdfryliq yikdglpnln 61 estrlifpdt fsicllrshq iiaskkidsq eflsavkeql lteananiif eyvldfwadg 121 gaplmnalrd lfskllnllk itypmstlkd vlfnwmneil evpstlrvqy ylidalssdf 181 dlyyiiekkp hfidnsfslm nsdllansvg kcivslllni yekhfkknes fvqewiqlwk 241 scalkyihdk qytksinlyi miplfknmpn saftlflecm snkdpsllls llkigqelgi 301 eeepfcdnky ttvdsvnkli eqdeyklqvf eiltfstkks kpirpfvfkt ikqylyvffv 361 dtelerrnyf cssmkhfifr trdcayslar darklkkaek fpdeqrekla qveearaflv 421 wlcnfikynl apgtlyqanv tslklmhili ksgvdkstpq kfldnqnkre ypfsipilqd 481 vtflrllidl lvsnyadvre lskemlfimi sadesrglfl dtldanalkw tatsllsdye 541 kgdagatvye fiftvmgsqr sfidqtidil aqmvqnlqnd sigcaensig phfaalslil 601 nkfnseenhq dtskiiskli nlvlksweat rnvvchdsah gilpekyanc gvpdqviish 661 afraikeasy lletilkkyp ltrdqldsig dlfivqlsti rhsgafqavl pglkafcirc 721 qlefpailee llsksvkslk sktqhitrrs gglpflvttv lsaevtkgrp llqktfenll 781 lvarlpipph qdefdlpqvn aincinaifv epklsvhcts fvsealelal lnfdcdiwal 841 rncsimlfts lqnrifgkvg rsvsaklfft kysglrqlll nilnssiaqy sgserksyqi 901 esiflvlnvl lrlrptagyt glkefnvsvy eclsnenwki rdmasrvlhm lsenfeeeir 961 klldlasiak qnqlhghlla lqqlvpqyls gtrdmeliqr ilekkrmlll enkcfitkka 1021 ylkltccile tcdipdsilk dyistlrntf iaenneyvvd gskqlylaqi ldmllkyeds 1081 iylddicllg lyspfyeaql stlqymntnf hwettrnsef leqlqlllrv pdllpmakal 1141 vvkilsrkkn tlslttctdl lktnnsedtk laavsslsak lssqtfhqvw nllqgffads 1201 cskdfrlasl ecltaypesc knsrillqly nflwdddsei rekasfylnk nfiqtadwey 1261 nrntsvtali ftkkfvdvft ssevveelcl qlfqylneyd mfaaeesakn clftiekdnq 1321 finelqkamh ilnmikltgr diskcykdqi hhlksalleh fntedfkdsp lgwcsnaeif 1381 sritllkeli qhyspsdyen finvltkhsv hpliisysql // LOCUS NP_013987 153 aa linear PLN 30-JUN-2025 DEFINITION translation initiation complex factor eIF1A [Saccharomyces cerevisiae S288C]. ACCESSION NP_013987 VERSION NP_013987.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182767.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10160. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..153 /product="translation initiation complex factor eIF1A" /calculated_mol_wt="17304" Region 17..132 /region_name="S1_like" /note="Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain. Both domains...; cl09927" /db_xref="CDD:471952" Site order(41..42,46,60..63,66,71) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240219" CDS 1..153 /gene="TIF11" /locus_tag="YMR260C" /coded_by="NM_001182767.1:1..462" /experiment="EXISTENCE:direct assay:GO:0001731 formation of translation preinitiation complex [PMID:17434125|PMID:15664195|PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0003725 double-stranded RNA binding [PMID:17673174]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:16380131]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:16380131|PMID:10982835]" /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]" /experiment="EXISTENCE:direct assay:GO:0043024 ribosomal small subunit binding [PMID:17434125|PMID:16461768|PMID:12860115]" /experiment="EXISTENCE:genetic interaction:GO:0001732 formation of cytoplasmic translation initiation complex [PMID:17242201]" /experiment="EXISTENCE:mutant phenotype:GO:0001677 formation of translation initiation ternary complex [PMID:20048003]" /experiment="EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:17332751|PMID:16193068|PMID:12514125|PMID:15838098]" /experiment="EXISTENCE:mutant phenotype:GO:0001732 formation of cytoplasmic translation initiation complex [PMID:16461768|PMID:20048003]" /experiment="EXISTENCE:mutant phenotype:GO:0002188 translation reinitiation [PMID:20048003|PMID:16193068]" /experiment="EXISTENCE:mutant phenotype:GO:0043024 ribosomal small subunit binding [PMID:16193068]" /note="Translation initiation factor eIF1A; essential protein that forms a complex with Sui1p (eIF1) and 40S ribosomal subunit and scans for start codons; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3; ortholog of bacterial translation initiation factor IF1" /db_xref="GeneID:855302" /db_xref="SGD:S000004873" ORIGIN 1 mgkkntkggk kgrrgkndsd gpkreliyke egqeyaqitk mlgngrveas cfdgnkrmah 61 irgklrkkvw mgqgdiilvs lrdfqddqcd vvhkynldea rtlknqgelp enakinetdn 121 fgfesdedvn fefgnadedd eegedeeldi ddi // LOCUS NP_013988 1054 aa linear PLN 30-JUN-2025 DEFINITION trehalose 6-phosphate synthase/phosphatase complex subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_013988 VERSION NP_013988.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182768.1 REFERENCE 1 (residues 1 to 1054) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1054) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1054) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1054) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1054) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1054) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1054) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10161. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1054 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1054 /product="trehalose 6-phosphate synthase/phosphatase complex subunit" /calculated_mol_wt="118705" Region 286..765 /region_name="Glyco_transf_20" /note="Glycosyltransferase family 20; pfam00982" /db_xref="CDD:425972" Region 785..1010 /region_name="Trehalose_PPase" /note="Trehalose-phosphatase; pfam02358" /db_xref="CDD:426737" CDS 1..1054 /gene="TPS3" /locus_tag="YMR261C" /coded_by="NM_001182768.1:1..3165" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:genetic interaction:GO:0004805 trehalose-phosphatase activity [PMID:9837904]" /experiment="EXISTENCE:mutant phenotype:GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [PMID:9837904]" /experiment="EXISTENCE:mutant phenotype:GO:0005992 trehalose biosynthetic process [PMID:9837904]" /experiment="EXISTENCE:mutant phenotype:GO:0030234 enzyme regulator activity [PMID:9837904]" /experiment="EXISTENCE:physical interaction:GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [PMID:9837904]" /note="Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication" /db_xref="GeneID:855303" /db_xref="SGD:S000004874" ORIGIN 1 mtiivaslfl pytpqfeadv tnsdtaklve ssmikvdcnn qelsnnkqer sssvtsassh 61 yiglpqeaqi ngeplqranv gspatgvnyh nememlsseq fleeltanat haansgippa 121 nnpvssgsta qrpsveeffs apsarvcsps qeasassisa srssahhndl ssslmknpnl 181 sfdshpprvr sssksavitp vsksvpdvdp avvdvakvre efqqqaslps mkrvsgstag 241 dssiassssn lrysqqfqdn fiedtdsedd idsdletdat kkynvpkfgg ysnnaklras 301 lmrnsyelfk hlpwtivdsd kgngslknav niavaektvk epvswvgtmg iptdelphev 361 chkiskkleq dfssfpvvtd ditfkgaykn yakqilwptl hyqipdnpns kafedhswdy 421 yqkvnqkfsd rivsvykpgd tiwihdyhlm lvpqmvrekl pkakigfflh vsfpssevfr 481 clanrerile giiganfvgf qtkeykrhfl qtcnrllaad vsndevkyhc nivsvmyapi 541 gidyyhltsq lrngsvlewr qlikerwrnk klivcrdqfd rirglqkkml ayerflienp 601 eyiekvvliq icigkssdpe yerqimvvvd rinslssnis isqpvvflhq dldfaqylal 661 nceadvflvd alregmnltc hefivssfek naplllseft gsssvlkega ilinpwdinh 721 vaqsikrsle mspeekrrrw kklfksvieh dsdnwitkcf eyinnawesn qetstvfnla 781 pekfcadyka skkhlfifki sepptsrmls llselssnni vyvlssftkn tfeslyngvl 841 nigliaenga yvrvngswyn iveeldwmke vakifdekve rlpgsyykia dsmirfhten 901 addqdrvptv igeaithint lfddrdihay vhkdivfvqq tglalaaaef lmkfynsgvs 961 ptdnsrisls rtsssmsvgn nkkhfqnqvd fvcvsgstsp iieplfklvk qeveknnlkf 1021 gytilygssr styakehing vnelftilhd ltaa // LOCUS NP_013989 313 aa linear PLN 30-JUN-2025 DEFINITION putative endodeoxyribonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_013989 VERSION NP_013989.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182769.2 REFERENCE 1 (residues 1 to 313) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 313) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 313) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 313) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10162. On Apr 26, 2011 this sequence version replaced NP_013989.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..313 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..313 /product="putative endodeoxyribonuclease" /calculated_mol_wt="35901" Region 5..313 /region_name="TatD_DNase" /note="TatD related DNase; pfam01026" /db_xref="CDD:425997" Site order(8,10,180,208,262) /site_type="active" /db_xref="CDD:238617" CDS 1..313 /locus_tag="YMR262W" /coded_by="NM_001182769.2:1..942" /note="hypothetical protein; interacts weakly with Knr4p; YMR262W is not an essential gene" /db_xref="GeneID:855304" /db_xref="SGD:S000004875" ORIGIN 1 mnklvdahch vitdpdntfc gddggsqgtl rcvmssnpyd wnnlkklagr stskndicvg 61 fgvhpwyshl fyvgsrrdkv shyqdvleyk neeqfdslvq vlpepldlee yikrefndtl 121 vsvigeigld klfrlpangf ymqnekarlt tvkvklshqe tvfrrfcrla rhtskpisih 181 dvkchgklnd icneelltyh svkiclhsyt gsketllgqw lkkfppdrif vslskwinfk 241 dpeegdalvr slpstcilte tdypidnpdp syqkalteql qylnaqiara wdetldasqa 301 alrvyenfqk fik // LOCUS NP_013990 201 aa linear PLN 30-JUN-2025 DEFINITION Sap30p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013990 VERSION NP_013990.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182770.1 REFERENCE 1 (residues 1 to 201) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 201) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 201) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 201) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10163. Method: conceptual translation. FEATURES Location/Qualifiers source 1..201 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..201 /product="Sap30p" /calculated_mol_wt="22895" Region 110..186 /region_name="SAP30_Sin3_bdg" /note="Sin3 binding region of histone deacetylase complex subunit SAP30; pfam13867" /db_xref="CDD:464006" CDS 1..201 /gene="SAP30" /locus_tag="YMR263W" /coded_by="NM_001182770.1:1..606" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286008|PMID:19040720|PMID:16286007|PMID:16314178]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:9651585]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19270272]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20398213|PMID:17210643]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:16286008|PMID:10388812]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:10082585|PMID:16286008|PMID:10388812]" /experiment="EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:18202364]" /note="Component of Rpd3L histone deacetylase complex; involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance" /db_xref="GeneID:855305" /db_xref="SGD:S000004876" ORIGIN 1 marpvntnae tesrgrptqg ggyasnnngs cnnnngsnnn nnnnnnnnnn snnsnnnngp 61 tssgrtngkq rltaaqqqyi knliethitd nhpdlrpksh pmdfeeytda flrrykdhfq 121 ldvpdnltlq gyllgsklga ktysykrntq gqhdkrihkr dlanvvrrhf dehsiketdc 181 ipqfiykvkn qkkkfkmefr g // LOCUS NP_013991 203 aa linear PLN 30-JUN-2025 DEFINITION Cue1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013991 VERSION NP_013991.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182771.1 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10164. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..203 /product="Cue1p" /calculated_mol_wt="22632" Region 67..103 /region_name="CUE_Cue1p_like" /note="CUE domain found in yeast ubiquitin-binding protein CUE1 (Cue1p), CUE4 (Cue4p) and similar proteins; cd14424" /db_xref="CDD:270607" Region 151..202 /region_name="Cue1_U7BR" /note="Ubc7p-binding region of Cue1; pfam18499" /db_xref="CDD:408292" CDS 1..203 /gene="CUE1" /locus_tag="YMR264W" /gene_synonym="KIS4" /coded_by="NM_001182771.1:1..612" /experiment="EXISTENCE:direct assay:GO:0000837 Doa10p ubiquitin ligase complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9388185]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:23665229]" /experiment="EXISTENCE:direct assay:GO:0097027 ubiquitin-protein transferase activator activity [PMID:18321851]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:9388185]" /experiment="EXISTENCE:mutant phenotype:GO:0097051 establishment of protein localization to endoplasmic reticulum membrane [PMID:9388185]" /note="Ubiquitin-binding protein; ER membrane protein that recruits and integrates the ubiquitin-conjugating enzyme Ubc7p into ER membrane-bound ubiquitin ligase complexes that function in the ER-associated degradation (ERAD) pathway for misfolded proteins; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination and to promote diubiquitin elongation, facilitating polyubiquitin chain formation" /db_xref="GeneID:855306" /db_xref="SGD:S000004877" ORIGIN 1 medsrllitl ilvfgviflk kffqsnqhps aqrlsatgvn ahgrpqgstq nalrrtgrvn 61 gghpvttqmv etvqnlapnl hpeqirysle ntgsveetve rylrgdefsf ppgfepsrap 121 mganaavdnn aagggefndp rkknmicaen lldkfhvdln edmsnlsfkd ldieerkrll 181 vwqarknlet klqsdkdlqs llt // LOCUS NP_013992 461 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR265C [Saccharomyces cerevisiae S288C]. ACCESSION NP_013992 VERSION NP_013992.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182772.1 REFERENCE 1 (residues 1 to 461) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 461) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 461) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 461) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10165. Method: conceptual translation. FEATURES Location/Qualifiers source 1..461 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..461 /product="uncharacterized protein" /calculated_mol_wt="53975" Region 59..253 /region_name="HAD_SAK_1" /note="HAD domain family 1 in Swiss Army Knife RNA repair proteins; pfam10307" /db_xref="CDD:431209" CDS 1..461 /locus_tag="YMR265C" /coded_by="NM_001182772.1:1..1386" /note="hypothetical protein" /db_xref="GeneID:855307" /db_xref="SGD:S000004878" ORIGIN 1 meefeefrrk gemssrcgnh rvlrkwnsca celavpfevp ehaitklhiy dfdntlfatp 61 gpteqlytre llnlltsstl pnggwwnepg flqaaieisk tkprryswna divklaeesy 121 sakdtisivl tgreeskfhk liehalqtar shwkcsenef rfnavclkkr aiseytskyk 181 kelmrdfley ypslrelsiy ddrihqidaf ksffhsldlp rlkwsaipvr pftkslpreq 241 elemvmdmvr knnsqalsts qkfdlrrtpr qigyilctas hrllsievik ylkrrkgrrt 301 frpklyehpl yipcaepgkd ipaleiakvw snndtrtfds ekkvqhisqi fyleqpgkci 361 vhfqvtdlav iasahhnrrk plevyfkatp epnrytftlf peyivtghfy krdriedlev 421 vterlincke dihwvpldnt ipikaffgrf aklaaipcsn a // LOCUS NP_013993 953 aa linear PLN 30-JUN-2025 DEFINITION Rsn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013993 VERSION NP_013993.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182773.1 REFERENCE 1 (residues 1 to 953) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 953) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 953) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 953) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10166. Method: conceptual translation. FEATURES Location/Qualifiers source 1..953 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..953 /product="Rsn1p" /calculated_mol_wt="107542" Region 21..914 /region_name="COG5594" /note="Uncharacterized integral membrane protein [Function unknown]" /db_xref="CDD:227881" CDS 1..953 /gene="RSN1" /locus_tag="YMR266W" /coded_by="NM_001182773.1:1..2862" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:17005914]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Membrane hypothetical protein; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane" /db_xref="GeneID:855308" /db_xref="SGD:S000004879" ORIGIN 1 mnstnstnst ttatstntst qqvvtslvsn gtifgvfvia flilriklkr iyepkssfnl 61 ineekkpepl pqgvwqwlkp llkksdnfvi qqagldgyff lrylfiiaiy cavsmsyifp 121 illsinasng nhesglnqla yqnvkhrgry fahvfcgwif fwgflyiiyr elyfytsmkq 181 avlaspryak klssrtvlfq tvpkqylsee efsklfdgvk rvwiargsgs ieamvkardn 241 maiqlegaet kylkaalkki kklnkkspql svsdniaeyv pdkkrphhki nkvakfffgk 301 kvdtisyike elpklnqkvk alqedhenss pfnsvfvefe sqyqaqvaaq ittyhaplfm 361 tpvyigieps dvvwfnlrmf wwerlgrevs avsaivalvi lwafpvafvg misnitsltn 421 evkwlkfiyk lpkqllgllt slaptvalav lmsflpkfir gmaitqgaps kqnveyftqq 481 ayfafqviqv flvttlssaa tstvteivke ptkamdllas nlpkasnffm syvilqglsi 541 ssgallqivp lilfyvlgaf ldgtvrkkwn rfcglssmqw gtafpvytnl avitfsysii 601 splillfaav affllyiayl ynltyvyqes pdargiyypr alfqtivgiy igqicllglf 661 avgkgwgpiv lqvigicvtv lihlhlsaaf dhlskvipvd tmkpldgvsd tpsfkniykg 721 iestkvkknt fganidmdgi kelpefpikk yhkrsesvte qqvensifse ntfeyqfnpa 781 neanadghai naenliedvp lladgdtmki ppapwwkrfl kphiyysyka vksrlpeiyg 841 lvdpdervnd fdishaydyp avsaqcpelw iprdpfgfsk llisdvsgvv emndenatid 901 enlkftlrdv pppyndvkde angeangefd taskennpfa dpkykeeesr sav // LOCUS NP_013994 310 aa linear PLN 30-JUN-2025 DEFINITION inorganic diphosphatase PPA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013994 VERSION NP_013994.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182774.1 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10167. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..310 /product="inorganic diphosphatase PPA2" /EC_number="3.6.1.1" /calculated_mol_wt="35442" Region 6..271 /region_name="pyrophosphatase" /note="Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; cl00217" /db_xref="CDD:469666" Site order(84..85,164..165) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238239" Site order(89,111,126,229..230) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238239" Site order(91,152,157,184,189) /site_type="metal-binding" /note="metal binding sites [ion binding]" /db_xref="CDD:238239" CDS 1..310 /gene="PPA2" /locus_tag="YMR267W" /gene_synonym="IPP2" /coded_by="NM_001182774.1:1..933" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0004427 inorganic diphosphate phosphatase activity [PMID:1648084]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:1648084]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:1648084]" /note="Mitochondrial inorganic pyrophosphatase; required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate; human ortholog, PPA2, functionally complements the null mutant; mutations in human PPA2 cause a mitochondrial disease resulting in sudden unexpected cardiac arrest in infants" /db_xref="GeneID:855309" /db_xref="SGD:S000004880" ORIGIN 1 mnllrmnalt skarsierlk qtlnilsirn hrqfstiqqg skytlgfkky ltllngevgs 61 ffhdvpldln ehektvnmiv evprwttgkf eiskelrfnp ivqdtkngkl rfvnnifpyh 121 gyihnygaip qtwedptieh klgkcdvalk gdndpldcce igsdvlemgs ikkvkvlgsl 181 aliddgeldw kvividvndp lsskiddlek ieeyfpgild ttrewfrkyk vpagkplnsf 241 afheqyqnsn ktiqtikkch nswknlisgs lqekydnlpn teragngvtl edsvkppsqi 301 ppevqkwyyv // LOCUS NP_013995 444 aa linear PLN 30-JUN-2025 DEFINITION U6 snRNP complex subunit PRP24 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013995 VERSION NP_013995.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182775.1 REFERENCE 1 (residues 1 to 444) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 444) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 444) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 444) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10168. Method: conceptual translation. FEATURES Location/Qualifiers source 1..444 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..444 /product="U6 snRNP complex subunit PRP24" /calculated_mol_wt="50718" Region 41..113 /region_name="RRM1_Prp24" /note="RNA recognition motif 1 in fungal pre-messenger RNA splicing protein 24 (Prp24) and similar proteins; cd12296" /db_xref="CDD:409737" Region 117..195 /region_name="RRM2_Prp24" /note="RNA recognition motif 2 in fungal pre-messenger RNA splicing protein 24 (Prp24) and similar proteins; cd12297" /db_xref="CDD:409738" Site order(118,120,148..150,153,160,162,193) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:409738" Region 210..286 /region_name="RRM3_Prp24" /note="RNA recognition motif 3 in fungal pre-messenger RNA splicing protein 24 (Prp24) and similar proteins; cd12298" /db_xref="CDD:409739" Region 312..386 /region_name="RRM4_Prp24" /note="RNA recognition motif 4 in fungal pre-messenger RNA splicing protein 24 (Prp24) and similar proteins; cd12299" /db_xref="CDD:409740" Region 425..443 /region_name="Lsm_interact" /note="Lsm interaction motif; pfam05391" /db_xref="CDD:398843" CDS 1..444 /gene="PRP24" /locus_tag="YMR268C" /coded_by="NM_001182775.1:1..1335" /experiment="EXISTENCE:direct assay:GO:0000244 spliceosomal tri-snRNP complex assembly [PMID:9452384]" /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:20181740]" /experiment="EXISTENCE:mutant phenotype:GO:0000245 spliceosomal complex assembly [PMID:10022888]" /experiment="EXISTENCE:physical interaction:GO:0017069 snRNA binding [PMID:16410014]" /note="Splicing factor that reanneals snRNPs during spliceosome recycling; reanneals U4 and U6 snRNPs" /db_xref="GeneID:855310" /db_xref="SGD:S000004881" ORIGIN 1 meyghharpd skrpldegsp aaagltskka nealtrnrel ttvlvknlpk synqnkvyky 61 fkhcgpiihv dvadslkknf rfariefary dgalaaitkt hkvvgqneii vshltectlw 121 mtnfppsytq rnirdllqdi nvvalsirlp slrfntsrrf ayidvtsked arycveklng 181 lkiegytlvt kvsnpleksk rtdsatlegr eimirnlste lldenllres fegfgsieki 241 nipagqkehs fnnccafmvf enkdsaeral qmnrsllgnr eisvsladkk pflernevkr 301 llasrnskel etliclfpls dkvspslicq flqeeihine kdirkillvs dfngaiiifr 361 dskfaakmlm ilngsqfqgk virsgtindm kryynnqqnh smkhvkpsci nmmekgpnlq 421 vkkkipdkqe qmsnddfrkm flge // LOCUS NP_013996 211 aa linear PLN 30-JUN-2025 DEFINITION Tma23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013996 VERSION NP_013996.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182776.1 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10169. On Mar 1, 2004 this sequence version replaced NP_013996.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..211 /product="Tma23p" /calculated_mol_wt="23818" CDS 1..211 /gene="TMA23" /locus_tag="YMR269W" /gene_synonym="YMR268W-A" /coded_by="NM_001182776.1:1..636" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:17425675]" /experiment="EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:17425675]" /note="Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan" /db_xref="GeneID:855311" /db_xref="SGD:S000004882" ORIGIN 1 mdskeylisy gwkegeafre gglkrpilvk hkrdkkglgn apggndgeaw werlfdghlk 61 nldvstdsnn gsikftqnea vatavsksss plyrwfvkge glkgtitnlg kkeeasfvvs 121 sassskgkkr rrrdeddnkv krkklkkdkk tsndseskkk kkkkskkesk kgkkskhssd 181 egdkskhkks kkskkhkkee ssarrdrkeh i // LOCUS NP_013997 365 aa linear PLN 30-JUN-2025 DEFINITION Rrn9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_013997 VERSION NP_013997.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182777.1 REFERENCE 1 (residues 1 to 365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 365) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10170. Method: conceptual translation. FEATURES Location/Qualifiers source 1..365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..365 /product="Rrn9p" /calculated_mol_wt="42682" Region 47..103 /region_name="RRN9" /note="RNA polymerase I specific transcription initiation factor; pfam10680" /db_xref="CDD:463176" CDS 1..365 /gene="RRN9" /locus_tag="YMR270C" /coded_by="NM_001182777.1:1..1098" /experiment="EXISTENCE:direct assay:GO:0000500 RNA polymerase I upstream activating factor complex [PMID:8846924]" /experiment="EXISTENCE:direct assay:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:8846924]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22362748]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:9632758]" /experiment="EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8846924]" /experiment="EXISTENCE:mutant phenotype:GO:0017025 TBP-class protein binding [PMID:9632758]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:8846924]" /experiment="EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:9632758]" /note="Protein involved in promoting high level transcription of rDNA; subunit of UAF (upstream activation factor) for RNA polymerase I" /db_xref="GeneID:855312" /db_xref="SGD:S000004883" ORIGIN 1 msdldeesqi etqidapied iirgselttt tadketlksa nelldslehs hrvdlslhly 61 sayllkrlly kanekkhfye vnqfvktqik dnwtswpnpn tiidpsvdkl yedipegian 121 vsvqpgeisn ralmhasdmm rveldaqwqk flsksaldhd vtldvdelni pneisrnilv 181 kldslfeglh dkiakenefd vrqdkhsnni ranqiddepm qanrrikyty hdlvsrgcem 241 nedmtdiymk slelyndipe kykkrkfrlp kqilkkyhqp kktssylkel lsktredfip 301 vekllkdkrl tskdksklqr lnreetedal nkrtffqvkg yledeneisd yelddcliel 361 pngni // LOCUS NP_013998 227 aa linear PLN 30-JUN-2025 DEFINITION orotate phosphoribosyltransferase URA10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_013998 VERSION NP_013998.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182778.1 REFERENCE 1 (residues 1 to 227) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 227) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 227) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 227) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 227) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10171. Method: conceptual translation. FEATURES Location/Qualifiers source 1..227 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..227 /product="orotate phosphoribosyltransferase URA10" /EC_number="2.4.2.10" /calculated_mol_wt="24680" Region 17..202 /region_name="pyrE" /note="orotate phosphoribosyltransferase; TIGR00336" /db_xref="CDD:129436" Site order(78,80,135..137,139..143,167) /site_type="active" /db_xref="CDD:206754" CDS 1..227 /gene="URA10" /locus_tag="YMR271C" /coded_by="NM_001182778.1:1..684" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0004588 orotate phosphoribosyltransferase activity [PMID:2182197]" /experiment="EXISTENCE:genetic interaction:GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process [PMID:2182197]" /experiment="EXISTENCE:genetic interaction:GO:0046132 pyrimidine ribonucleoside biosynthetic process [PMID:2182197]" /experiment="EXISTENCE:mutant phenotype:GO:0004588 orotate phosphoribosyltransferase activity [PMID:2182197]" /experiment="EXISTENCE:mutant phenotype:GO:0046132 pyrimidine ribonucleoside biosynthetic process [PMID:2182197]" /note="Minor orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA10 has a paralog, URA5, that arose from the whole genome duplication" /db_xref="GeneID:855313" /db_xref="SGD:S000004884" ORIGIN 1 msasttslee yqktflelgl eckalrfgsf klnsgrqspy ffnlslfnsg kllanlatay 61 ataiiqselk fdvifgpayk giplaaivcv klaeiggtkf qgiqyafnrk kvkdhgeggi 121 ivgasledkr vliiddvmta gtaineafei isiaqgrvvg civaldrqev ihesdperts 181 atqsvskryn vpvlsivslt qvvqfmgnrl speqksaien yrkaygi // LOCUS NP_013999 384 aa linear PLN 30-JUN-2025 DEFINITION fatty acid alpha-hydroxylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_013999 VERSION NP_013999.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182779.1 REFERENCE 1 (residues 1 to 384) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 384) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 384) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 384) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10172. Method: conceptual translation. FEATURES Location/Qualifiers source 1..384 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..384 /product="fatty acid alpha-hydroxylase" /EC_number="1.14.18.6" /EC_number="1.14.18.7" /calculated_mol_wt="44751" Region 13..90 /region_name="Cyt-b5" /note="Cytochrome b5-like Heme/Steroid binding domain; pfam00173" /db_xref="CDD:459698" Region 149..380 /region_name="FA_hydroxylase" /note="Fatty acid hydroxylase; cl01132" /db_xref="CDD:412761" CDS 1..384 /gene="SCS7" /locus_tag="YMR272C" /gene_synonym="FAH1" /coded_by="NM_001182779.1:1..1155" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006673 inositol phosphoceramide metabolic process [PMID:9559540]" /experiment="EXISTENCE:mutant phenotype:GO:0000038 very long-chain fatty acid metabolic process [PMID:9353282]" /experiment="EXISTENCE:mutant phenotype:GO:0006673 inositol phosphoceramide metabolic process [PMID:9353282|PMID:9559540|PMID:16652392|PMID:9368039]" /experiment="EXISTENCE:mutant phenotype:GO:0080132 fatty acid 2-hydroxylase activity [PMID:9559540|PMID:9353282]" /experiment="EXISTENCE:mutant phenotype:GO:0102772 sphingolipid C4-monooxygenase activity [PMID:9353282]" /note="Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth" /db_xref="GeneID:855315" /db_xref="SGD:S000004885" ORIGIN 1 mstntsktle lfskktvqeh ntandcwvty qnrkiydvtr flsehpggde sildyagkdi 61 teimkdsdvh ehsdsayeil edeyligyla tdeeaarllt nknhkvevql sadgtefdst 121 tfvkelpaee klsiatdysn dykkhkfldl nrpllmqilr sdfkkdfyvd qihrprhygk 181 gsaplfgnfl epltktawwv vpvawlpvvv yhmgvalknm nqlfacflfc vgvfvwtlie 241 yglhrflfhf ddwlpesnia fathfllhgc hhylpmdkyr lvmpptlfvi lcapfyklvf 301 allplywaya gfagglfgyv cydechfflh hsklppfmrk lkkyhlehhy knyqlgfgvt 361 swfwdevfgt ylgpdaplsk mkye // LOCUS NP_878149 35 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR272W-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878149 VERSION NP_878149.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184617.1 REFERENCE 1 (residues 1 to 35) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 35) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 35) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 35) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 35) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 35) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 35) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10173. Method: conceptual translation. FEATURES Location/Qualifiers source 1..35 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..35 /product="uncharacterized protein" /calculated_mol_wt="3978" CDS 1..35 /locus_tag="YMR272W-B" /coded_by="NM_001184617.1:1..108" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole" /db_xref="GeneID:1466507" /db_xref="SGD:S000028696" ORIGIN 1 mrslvfvqls llsweifcge rsfvsmkaif scmyv // LOCUS NP_014000 915 aa linear PLN 30-JUN-2025 DEFINITION Zds1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014000 VERSION NP_014000.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182780.1 REFERENCE 1 (residues 1 to 915) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 915) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 915) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 915) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 915) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 915) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 915) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10174. Method: conceptual translation. FEATURES Location/Qualifiers source 1..915 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..915 /product="Zds1p" /calculated_mol_wt="103228" Region <735..>799 /region_name="PRK12757" /note="cell division protein FtsN; Provisional" /db_xref="CDD:237191" Region 845..893 /region_name="Zds_C" /note="Activator of mitotic machinery Cdc14 phosphatase activation C-term; pfam08632" /db_xref="CDD:370018" CDS 1..915 /gene="ZDS1" /locus_tag="YMR273C" /gene_synonym="CES1; CKM1; NRC1; OSS1" /coded_by="NM_001182780.1:1..2748" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:8816439]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21536748]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:8816439]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:21536748]" /experiment="EXISTENCE:genetic interaction:GO:0004864 protein phosphatase inhibitor activity [PMID:18762578]" /experiment="EXISTENCE:genetic interaction:GO:0006406 mRNA export from nucleus [PMID:15619606]" /experiment="EXISTENCE:genetic interaction:GO:0010971 positive regulation of G2/M transition of mitotic cell cycle [PMID:20980617]" /experiment="EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:8816439]" /experiment="EXISTENCE:mutant phenotype:GO:0004864 protein phosphatase inhibitor activity [PMID:18762578]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:15619606]" /experiment="EXISTENCE:mutant phenotype:GO:0010971 positive regulation of G2/M transition of mitotic cell cycle [PMID:21536748]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:8816439]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:10662670]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:18762578]" /experiment="EXISTENCE:physical interaction:GO:0006406 mRNA export from nucleus [PMID:15619606]" /note="Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication" /db_xref="GeneID:855316" /db_xref="SGD:S000004886" ORIGIN 1 msnrdnesml rttssdkaia sqrdkrksev liaaqsldne irsvknlkrl sigsmdllid 61 peldikfgge ssgrrswsgt tsssasmpsd tttvnntrys dptplenlhg rgnsgiessn 121 ktkqgnylgi kkgvhspsrk lnanvlkknl lwvpanqhpn vkpdnflelv qdtlqniqls 181 dngedndgns nenndiedng edkesqsyen kenntinlnr glsrhgnasl irrpstlrrs 241 ytefddnedd dnkgdsaset vnkveerisk ikerpvslrd iteeltkisn sagltdndai 301 tlartlsmag sysdkkdqpq peghydegdi gfstsqantl ddgefasnmp inntmtwper 361 sslrrsrfnt yrirsqeqek eveqsvdemk nddeerlklt kntikveidp hkspfrqqde 421 dsenmsspgs igdfqdiynh yrqssgeweq emgiekeaee vpvkvrndtv eqdlelregt 481 tdmvkpsatd dnketkrhrr rngwtwlnnk msreddneen qgddeneenv dsqrmeldns 541 kkhyislfng gektevsnke emnnsststa tsqtrqkiek tfanlfrrkp hhkhdasssp 601 ssspssspsi pnndavhvrv rkskklgnks grepvepivl rnrprphrhh hsrhgsqkis 661 vktlkdsqpq qqiplqpqle gaieiekkee sdseslpqlq pavsvsstks nsrdreeeea 721 kkknkkrsnt teisnqqhsk hvqkentdeq kaqlqapaqe qvqtsvpvqa sapvqnsapv 781 qtsapveasa qtqapaappl khtsilpprk ltfadvkkpd kpnspvqftd safgfplpll 841 tvstvimfdh rlpinverai yrlshlklsn skrglreqvl lsnfmyayln lvnhtlymeq 901 vahdkeqqqq qqqqp // LOCUS NP_014001 315 aa linear PLN 30-JUN-2025 DEFINITION CAAX prenyl protease [Saccharomyces cerevisiae S288C]. ACCESSION NP_014001 VERSION NP_014001.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182781.1 REFERENCE 1 (residues 1 to 315) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 315) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 315) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 315) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10175. Method: conceptual translation. FEATURES Location/Qualifiers source 1..315 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..315 /product="CAAX prenyl protease" /EC_number="3.4.26.1" /calculated_mol_wt="35780" Region 143..254 /region_name="Rce1-like" /note="Type II CAAX prenyl endopeptidase Rce1-like; pfam02517" /db_xref="CDD:460578" CDS 1..315 /gene="RCE1" /locus_tag="YMR274C" /coded_by="NM_001182781.1:1..948" /experiment="EXISTENCE:direct assay:GO:0004222 metalloendopeptidase activity [PMID:17942791]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9736709]" /experiment="EXISTENCE:genetic interaction:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:9065405|PMID:11581258|PMID:10825201]" /experiment="EXISTENCE:genetic interaction:GO:0071586 CAAX-box protein processing [PMID:9065405]" /experiment="EXISTENCE:mutant phenotype:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:10825201]" /experiment="EXISTENCE:mutant phenotype:GO:0071586 CAAX-box protein processing [PMID:16361710|PMID:9065405]" /note="Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone" /db_xref="GeneID:855317" /db_xref="SGD:S000004887" ORIGIN 1 mlqfstflvl lyisisyvlp lyatsqpegs krdnprtiks rmqkltimli snlflvpflq 61 sqlssttshi sfkdaflglg iipgyyaalp npwqfsqfvk dltkcvamll tlycgpvldf 121 vlyhllnpks siledfyhef lniwsfrnfi fapiteeify tsmllttyln liphsqlsyq 181 qlfwqpslff glahahhaye qlqegsmttv sillttcfqi lyttlfgglt kfvfvrtggn 241 lwcciilhal cnimgfpgps rlnlhftvvd kkagrisklv siwnkcyfal lvlglislkd 301 tlqtlvgtpg yritl // LOCUS NP_014002 976 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-ubiquitin ligase BUL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014002 VERSION NP_014002.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182782.1 REFERENCE 1 (residues 1 to 976) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 976) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 976) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 976) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 976) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 976) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 976) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10176. Method: conceptual translation. FEATURES Location/Qualifiers source 1..976 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..976 /product="ubiquitin-ubiquitin ligase BUL1" /calculated_mol_wt="109044" Region 108..543 /region_name="Bul1_N" /note="Bul1 N terminus; pfam04425" /db_xref="CDD:398229" Region 690..974 /region_name="Bul1_C" /note="Bul1 C terminus; pfam04426" /db_xref="CDD:367936" CDS 1..976 /gene="BUL1" /locus_tag="YMR275C" /gene_synonym="DAG1; RDS1; SMM2" /coded_by="NM_001182782.1:1..2931" /experiment="EXISTENCE:direct assay:GO:0000151 ubiquitin ligase complex [PMID:9931424]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:10366593]" /experiment="EXISTENCE:genetic interaction:GO:0009749 response to glucose [PMID:29514933]" /experiment="EXISTENCE:genetic interaction:GO:0034450 ubiquitin-ubiquitin ligase activity [PMID:11352928]" /experiment="EXISTENCE:genetic interaction:GO:0070086 ubiquitin-dependent endocytosis [PMID:29514933]" /experiment="EXISTENCE:mutant phenotype:GO:0000209 protein polyubiquitination [PMID:8668140]" /experiment="EXISTENCE:mutant phenotype:GO:0006513 protein monoubiquitination [PMID:8668140]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /note="Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex; ubiquitin-binding adaptor involved in down-regulation of general amino acid transporter Gap1p upon shift to preferred nitrogen source; involved in lactate transporter Jen1p endocytosis; BUL1 has a paralog, BUL2, that arose from the whole genome duplication" /db_xref="GeneID:855318" /db_xref="SGD:S000004888" ORIGIN 1 makdlndsgf ppkrkpllrp qrsdftanss ttmnvnantr grgrqkqegg kgssrspslh 61 spkswirsas atgilglrrp elahshshap stgtpaggnr splrrstana tpvetgrslt 121 dgdinnvvdv lpsfemyntl hrhipqgnvd pdrhdfppsy qeannstatg aagssadlsh 181 qslstdalga trssstsnle nliplrtehh siaahqstav dedsldippi lddlndtdni 241 fidklytlpk mstpieitik ttkhapiphv kpeeesilke ytsgdlihgf itienksqan 301 lkfemfyvtl esyisiidkv kskrtikrfl rmvdlsasws yskialgsgv dfipadvdyd 361 gsvfglnnsr vlepgvkykk ffifklplql ldvtckqehf shcllppsfg idkyrnncky 421 sgikvnrvlg cghlgtkgsp iltndmsddn lsinytidar ivgkdqkask lyimkereyn 481 lrvipfgfda nvvgerttms qlnditklvq erldalrkif qrlekkepit nrdihgadls 541 gtiddsiesd sqeilqrkld qlhiknrnny lvnyndlklg hdldngrsgn sghntdtsra 601 wgpfveselk yklknksnss sflnfshfln sssssmssss nagknnhdlt gnkertglil 661 vkakipkqgl pywapsllrk tnvfeskskh dqenwvrlse lipedvkkpl ekldlqltci 721 esdnslphdp peiqsittel icitaksdns ipiklnsell mnkekltsik alyddfhski 781 ceyetkfnkn flelnelynm nrgdrrpkel kftdfitsql fndiesicnl kvsvhnlsni 841 fkkqvstlkq hskhalseds ishtgngsss spssasltpv tsssksslfl psgssstslk 901 ftdqivhkwv riaplqykrd invnlefnkd iketlipsfe sclccrfycv rvmikfenhl 961 gvakidipis vrqvtk // LOCUS NP_014003 373 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin domain-containing protein DSK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014003 VERSION NP_014003.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182783.1 REFERENCE 1 (residues 1 to 373) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 373) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 373) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 373) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10177. Method: conceptual translation. FEATURES Location/Qualifiers source 1..373 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..373 /product="ubiquitin domain-containing protein DSK2" /calculated_mol_wt="39215" Region 3..74 /region_name="Ubl_Dsk2p_like" /note="ubiquitin-like (Ubl) domain found in Saccharomyces cerevisiae proteasome interacting protein Dsk2p and similar proteins; cd16106" /db_xref="CDD:340523" Site order(41,43,45,47..48,61,63,69,71..74) /site_type="other" /note="Uba interaction site [polypeptide binding]" /db_xref="CDD:340523" Site order(45,47..50,69,71..72) /site_type="other" /note="Ufd2 interaction site [polypeptide binding]" /db_xref="CDD:340523" Region 149..185 /region_name="STI1" /note="Heat shock chaperonin-binding motif; smart00727" /db_xref="CDD:128966" Region 328..369 /region_name="UBA_Dsk2p_like" /note="UBA domain of Saccharomyces cerevisiae proteasome interacting protein Dsk2p and its homologs found in fungi; cd14324" /db_xref="CDD:270509" Site order(338,341..344,360..362,365,369) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270509" CDS 1..373 /gene="DSK2" /locus_tag="YMR276W" /coded_by="NM_001182783.1:1..1122" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:8070654]" /experiment="EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:genetic interaction:GO:0030474 spindle pole body duplication [PMID:8070654]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:11805328]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:15167887]" /experiment="EXISTENCE:mutant phenotype:GO:0072665 protein localization to vacuole [PMID:29444958]" /note="Nuclear-enriched ubiquitin-like polyubiquitin-binding protein; K48-Ub chain binding protein that also binds K63-linked chains in vitro; required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle; involved in proteolysis; interacts with the proteasome; contains an N-terminal Ub-like (UBL) and a C-terminal Ub-associated (UBA) domain; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855319" /db_xref="SGD:S000004889" ORIGIN 1 mslnihiksg qdkwevnvap estvlqfkea inkangipva nqrliysgki lkddqtvesy 61 hiqdghsvhl vksqpkpqta saagannata tgaaagtgat pnmssgqsag fnpladltsa 121 ryagylnmps admfgpdgga lnndsnnqde llrmmenpif qsqmnemlsn pqmldfmiqs 181 npqlqamgpq arqmlqspmf rqmltnpdmi rqsmqfarmm dpnagmgsag gaasafpapg 241 gdapeegsnt nttsssntgn nagtnagtna gantaanpfa sllnpalnpf anagnaastg 301 mpafdpalla smfqppvqas qaedtrppee ryehqlrqln dmgffdfdrn vaalrrsggs 361 vqgaldslln gdv // LOCUS NP_014004 732 aa linear PLN 30-JUN-2025 DEFINITION protein serine/threonine phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014004 VERSION NP_014004.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182784.1 REFERENCE 1 (residues 1 to 732) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 732) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 732) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 732) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 732) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 732) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 732) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10178. Method: conceptual translation. FEATURES Location/Qualifiers source 1..732 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..732 /product="protein serine/threonine phosphatase" /EC_number="3.1.3.16" /calculated_mol_wt="83310" Region 88..>112 /region_name="Biotinyl_lipoyl_domains" /note="Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; cl11404" /db_xref="CDD:448245" Region 169..345 /region_name="FCP1_euk" /note="FCP1-like phosphatase, phosphatase domain; TIGR02250" /db_xref="CDD:131304" Site order(180..184,188..189,269..272,276,307,324..325,326..328) /site_type="active" /db_xref="CDD:319823" Region 491..588 /region_name="BRCT_CTDP1" /note="BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; cd17729" /db_xref="CDD:349361" CDS 1..732 /gene="FCP1" /locus_tag="YMR277W" /coded_by="NM_001182784.1:1..2199" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:10445027|PMID:11904169]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10445027|PMID:12370301]" /experiment="EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:10445027]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10445027]" /note="Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:855320" /db_xref="SGD:S000004890" ORIGIN 1 mttqirspqg lpypiqidkl ipsvgsylhe gdrllvykfw ylverasdtg dddnehdvsp 61 ggsagsngvs pptkqlresi effespyegd liswnvdvgd evatanqvic eikrpcnhdi 121 vygglctqcg kevsadafdg vpldvvgdvd lqiseteair tgkalkehlr rdkklilvvd 181 ldqtiihcgv dptiaewknd pnnpnfetlr dvksftldee lvlplmymnd dgsmlrpppv 241 rkcwyyvkvr pglkeffakv aplfemhiyt matrayalqi akivdptgel fgdrilsrde 301 ngslttksla klfptdqsmv vviddrgdvw nwcpnlikvv pynffvgvgd insnflpkqs 361 tgmlqlgrkt rqksqesqel ltdimdnekk lqekidkevk rqeeklnhql ataeeppane 421 skeeltkkle ysaslevqqq nrplaklqkh lhdqkllvdd ddelyylmgt lsnihktyyd 481 mlsqqnepep nlmeiipslk qkvfqncyfv fsgliplgtd iqrsdiviwt stfgatstpd 541 idyltthlit knpstykarl akkfnpqiki vhpdwifecl vnwkkvdekp ytlivdspis 601 deelqnfqtq lqkrqeylee tqeqqhmlts qenlnlfaag tswlnnddde dipdtasddd 661 edddhddesd dennsegidr krsiednhdd tsqkktkaep sqdgpvqhkg egddnedsds 721 qleeelmdml dd // LOCUS NP_014005 622 aa linear PLN 30-JUN-2025 DEFINITION phosphoribomutase PRM15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014005 VERSION NP_014005.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182785.1 REFERENCE 1 (residues 1 to 622) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 622) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 622) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 622) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10179. Method: conceptual translation. FEATURES Location/Qualifiers source 1..622 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..622 /product="phosphoribomutase PRM15" /EC_number="5.4.2.7" /calculated_mol_wt="70938" Region 52..596 /region_name="PGM2" /note="This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; cd05799" /db_xref="CDD:100092" Site order(56,58,61,158..160,168,325,327,329..330,383,404..406, 428,430,432,573,575..577,582) /site_type="active" /db_xref="CDD:100092" Site order(58,158,330,383,404,406,428,430,432,573,575..577,582) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:100092" Site order(158,325,327,329) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:100092" CDS 1..622 /gene="PRM15" /locus_tag="YMR278W" /gene_synonym="PGM3" /coded_by="NM_001182785.1:1..1869" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008973 phosphopentomutase activity [PMID:23103740]" /experiment="EXISTENCE:mutant phenotype:GO:0006148 inosine catabolic process [PMID:23670538]" /experiment="EXISTENCE:mutant phenotype:GO:0006166 purine ribonucleoside salvage [PMID:23670538]" /experiment="EXISTENCE:mutant phenotype:GO:0008973 phosphopentomutase activity [PMID:23103740|PMID:23670538]" /experiment="EXISTENCE:mutant phenotype:GO:0046115 guanosine catabolic process [PMID:23670538]" /note="Phosphoribomutase; catalyzes interconversion of ribose-1-phosphate and ribose-5-phosphate; has some phosphoglucomutase activity but primary activity in vivo is phosphoribomutase; contributes to ribose recycling in the pentose phosphate pathway; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential" /db_xref="GeneID:855321" /db_xref="SGD:S000004891" ORIGIN 1 mlqgiletvp sdlkdpislw fkqdrnpkti eevtalckks dwnelhkrfd sriqfgtagl 61 rsqmqagfsr mntlvviqas qglatyvrqq fpdnlvavvg hdhrfhskef arataaafll 121 kgfkvhylnp dhefvhtplv pfavdklkas vgvmitashn pkmdngykvy ysngcqiipp 181 hdhaisdsid anlepwanvw dfddvlnkal kqgklmysre emlklyleev sknlveinpl 241 klevkakpwf vytpmhgvgf difstivkkt lclvegkdyl cvpeqqnpdp sfptvgfpnp 301 eekgaldigi nlaekhdidl lvandpdadr fsvavkdmqs gewrqltgne igflfafyey 361 qkyksmdkef qhvhplamln stvssqmikk maeiegfhye dtltgfkwig nraillekkg 421 yyvpfgfeea igymfpameh dkdgisasiv flqayckwki dhnldplnvl engfkkygvf 481 keyngyyvvp nptvtkdifd yirnvytpeg asypssigee ievlyyrdlt tgyqsdtinh 541 kptlpvdpts qmitvsarps ngsenehirf tirgsgtepk lkvyieacan eeqrasflak 601 ltwnvlrrew frpdemnivt kf // LOCUS NP_014006 540 aa linear PLN 30-JUN-2025 DEFINITION Atr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014006 VERSION NP_014006.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182786.1 REFERENCE 1 (residues 1 to 540) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 540) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 540) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 540) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10180. Method: conceptual translation. FEATURES Location/Qualifiers source 1..540 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..540 /product="Atr2p" /calculated_mol_wt="59431" Region 74..519 /region_name="MFS_Amf1_MDR_like" /note="Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; cd17476" /db_xref="CDD:341029" Site order(83..84,87..88,91,123,176..177,179..181,184,206, 209..210,213,339,342..343,346..348,351,382,386,439..440, 444,448,464,467..468,471..472,475) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:341029" CDS 1..540 /gene="ATR2" /locus_tag="YMR279C" /coded_by="NM_001182786.1:1..1623" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0035445 borate transmembrane transport [PMID:21621519]" /note="Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication" /db_xref="GeneID:855322" /db_xref="SGD:S000004892" ORIGIN 1 mfsifkkkts vqgtdseide kitvkakdkv vvstedeevt tivsstkstq vtndspwqdp 61 tyfssfgkel mfiatcmlaq llnqagqtha lcimnvlsks fnseannqaw lmasfplaag 121 sfilisgrlg diyglkkmli vgyvivivws iisglskysn sdaffitsra fqgvgiafil 181 pnimglvghv ykvgsfrkni visfigacap tggmfgglfg glivtedpnq wpwvfyafgi 241 atflsllmaw ysipnnvptn ihglsmdwtg salaiiglil fnfvwnqapi vgwdkpyiiv 301 lliisviflv affvyeskya evpllpramt knrhmimill avflgwgsfg iwtfyyvsfq 361 lnlrhyspvw tggtyfvfvi fgsmaaffva fsikrlgpal llcfslmafd agsimfsvlp 421 veqsywklnf amqailcfgm dlsfpassii lsdglpmqyq gmagslvntv inysaslclg 481 mggtvehqin ksgndllkgy raavylgvgl aslgvvisvt ymlenlwnrh rksedrslea // LOCUS NP_014007 1433 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcription factor CAT8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014007 VERSION NP_014007.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182787.1 REFERENCE 1 (residues 1 to 1433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1433) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10181. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1433 /product="DNA-binding transcription factor CAT8" /calculated_mol_wt="160355" Region 65..106 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(65,69,74..77,79,82,92) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(70,73,80,87,90,97) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 108..134 /region_name="ZIP_Cat8" /note="Leucine zipper Dimerization domain of transcription factor Cat8 and similar proteins; cd15485" /db_xref="CDD:271243" Site order(109..110,112..113,116..117,119..120,123..124, 126..127,130..131) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:271243" Region 111..132 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:271243" Region <530..693 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..1433 /gene="CAT8" /locus_tag="YMR280C" /gene_synonym="DIL1; MSP8" /coded_by="NM_001182787.1:1..4302" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:10540293|PMID:14685767|PMID:11405098]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:14685767]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0045722 positive regulation of gluconeogenesis [PMID:11024040|PMID:7891685|PMID:8710504]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11024040|PMID:8710504|PMID:7891685]" /experiment="EXISTENCE:mutant phenotype:GO:2000876 positive regulation of glyoxylate cycle [PMID:11024040|PMID:8710504]" /note="Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:855323" /db_xref="SGD:S000004893" ORIGIN 1 mannnsdrqg leprvirtlg sqalsgpsis nrtssseanp hfsknvkeam iktasptpls 61 tpiyriaqac drcrskktrc dgkrpqcsqc aavgfecris dkllrkaypk gytesleerv 121 releaenkrl lalcdikeqq islvsqsrpq tstdntingn fkhdlkdapl nlsstniyll 181 nqtvnkqlqn gkmdgdnsgs amsplgappp pphkdhlcdg vsctnhlhvk ptstslndpt 241 aisfeqdeap glpavkalks mtthqrstql atlvslsipr steeilfipq lltrirqifg 301 fnskqclytv sllsslknrl paprllapst stklkekded kkldddsafv krfqstnlse 361 fvdlkkflis lkfninsfsk qsekpandqd dellslteik ellhlffkfw snqvpilnnd 421 hfliyfnnfv evvkhlsten letnnttkst vttnheifal kllmmlqmgl lvkikmekik 481 ytvpknpkak yarlmayyhq lsliipknpy flnmsttslp slqllslasf yylnvgdisa 541 iygvrgrivs maqqlrlhrc psavlsvhsn pvlqkfeqse rrllfwaiyy vdvfaslqlg 601 vprllkdfdi ecalpisdve ykdqlsmene kadkkakkiq lqgqvssfsl qiirfakilg 661 nildsifkrg mmderitsev alvhenaldn wrnqlpemyy fqitvngtvn ldeiratnqr 721 ntetkfdkkd iilfekkill lfyflaksmi hlpviatkpl pknvdnatkk kqsmfnndsk 781 gatnqdhmil dvdmtspair tsssyiilqq atnatltifq ainsmylplp lnvsrtlirf 841 sllcargsle ytkggalfld nknllldtik diendrlldl pgiaswhtlk lfdmsinlll 901 kapnvkverl dkflekklny ynrlmglppa tttslkplfg sqsknslenr qrtpnvkren 961 peheylygnd snnnnnseag hspmtnttng nkrlkyekda krnakdggis kgenahnfqn 1021 dtkknmstsn lfpfsfsntd ltalfthpeg pnctntnngn vdvcnrastd atdanienls 1081 flnmapflqt gnsnigqnti enkpmhmdai fslpsnldlm kdnmdskpeq lepvikqnpe 1141 nsknnqfhqk gkstnmeknn lsfnnksnys ltklmrllnn dnsfsnisin nflyqndqns 1201 asadpgtnkk avtnaganfk ppstgsntsq gsilgstkhg mdncdfndlg nfnnfmtnvn 1261 ysgvdydyiv daslglapll vdtpdisntn ttsttsnrsk nsiildttfn ddldrsrmna 1321 revlnptdsi lsqgmvssvs trntsnqrsl ssgndskgds ssqensksat gnqldtpstl 1381 fqmrrtssgp sashrgprrp qknryntdrs kssgggssnt dnvsdlfqwq nak // LOCUS NP_014008 304 aa linear PLN 30-JUN-2025 DEFINITION N-acetylglucosaminylphosphatidylinositol deacetylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014008 VERSION NP_014008.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182788.1 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10182. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..304 /product="N-acetylglucosaminylphosphatidylinositol deacetylase" /EC_number="3.5.1.89" /calculated_mol_wt="35315" Region 59..183 /region_name="PIG-L" /note="GlcNAc-PI de-N-acetylase; pfam02585" /db_xref="CDD:426852" CDS 1..304 /gene="GPI12" /locus_tag="YMR281W" /coded_by="NM_001182788.1:1..915" /experiment="EXISTENCE:direct assay:GO:0000225 N-acetylglucosaminylphosphatidylinositol deacetylase activity [PMID:10085243]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="ER membrane protein involved in the second step of GPI anchor assembly; the second step is the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp; GPI stands for glycosylphosphatidylinositol" /db_xref="GeneID:855324" /db_xref="SGD:S000004894" ORIGIN 1 mkmlrrtkvn fskllykitk laivltilyi yftpkivsrn naslqhifph kygdyeinlv 61 iahpddevmf fspiisqlns yfprtvpfni iclskgnaeg lgetrvreln esaalllhne 121 ravsvqvmdf qdgmdeiwdi dsitsslsqk idiknhnlnq iivtfdsygv snhinhkscy 181 aavkklvddy aqpktkrneq pphvtalylr syknnivlky nsfiweilki lydlispfrr 241 iiqalppnta aekdklslmn thaqyvlafa tmlnahesqv vwfrygwwif srfvfvnefd 301 vyty // LOCUS NP_014009 580 aa linear PLN 30-JUN-2025 DEFINITION Aep2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014009 VERSION NP_014009.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182789.1 REFERENCE 1 (residues 1 to 580) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 580) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 580) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 580) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10183. Method: conceptual translation. FEATURES Location/Qualifiers source 1..580 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..580 /product="Aep2p" /calculated_mol_wt="67393" Region 317..427 /region_name="ATP13" /note="Mitochondrial ATPase expression; pfam12921" /db_xref="CDD:372384" CDS 1..580 /gene="AEP2" /locus_tag="YMR282C" /gene_synonym="ATP13" /coded_by="NM_001182789.1:1..1743" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:7635208|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:genetic interaction:GO:0070124 mitochondrial translational initiation [PMID:10101162]" /note="Mitochondrial protein; likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader" /db_xref="GeneID:855325" /db_xref="SGD:S000004895" ORIGIN 1 mwinrlvkhp sysvlrfytk rlctvsvksl refgvlpnst ichsvyprrt yvmgravind 61 ilikksysth tvcaidrskd enngsaydkf eakgipidvh tlkriisssg mdesefsksi 121 sylfaktvdp epkdvlsled lsfllsklyt qrfqirricr dinakysefw fklfslyaek 181 vdakrnqvnl rntkldacei fdanlmiknf ielgqlgkaq kilsfildrn pdillspkna 241 distivhflq lrcgalapyw kipdnseqkq gflrkmvrlg akntsirlss tykamdhqtl 301 lkiadlalqe kkllnsedll stliqsfghl gqtqilerci ehiwqispqe fpshvvikhr 361 gcypsskilv silvsfyfnd hdlhrglsil dsfikhypdv kldalfwrrl fqlshfawtp 421 andkkatsvv rcwhlmkqwy askrlrpsvd yetlrqlydi mkktgnfplg idvlrsfkpg 481 iertraenag kvnniiikyq kciikelvnr grfsavrefi dsygfdrkmt kdlnifcanr 541 mflrskkmkn kienkkerek vrldsfddde ddgmiigslw // LOCUS NP_014010 513 aa linear PLN 30-JUN-2025 DEFINITION tRNA A64-2'-O-ribosylphosphate transferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014010 VERSION NP_014010.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182790.1 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10184. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..513 /product="tRNA A64-2'-O-ribosylphosphate transferase" /calculated_mol_wt="58751" Region 35..318 /region_name="Rit1_C" /note="Rit1 N-terminal domain; pfam17184" /db_xref="CDD:435771" Region 400..512 /region_name="Init_tRNA_PT" /note="Rit1 DUSP-like domain; pfam04179" /db_xref="CDD:427764" CDS 1..513 /gene="RIT1" /locus_tag="YMR283C" /coded_by="NM_001182790.1:1..1542" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016763 pentosyltransferase activity [PMID:7954819]" /experiment="EXISTENCE:mutant phenotype:GO:0016763 pentosyltransferase activity [PMID:7954819]" /experiment="EXISTENCE:mutant phenotype:GO:0019988 charged-tRNA amino acid modification [PMID:7954819]" /note="Initiator methionine 2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA" /db_xref="GeneID:855326" /db_xref="SGD:S000004896" ORIGIN 1 mvsrlskryr srvqfsisvm deniylslsq inkdirkenk svrnrlqsil ldnkflqdrv 61 ipifphypli pnercglwyc npssfkqtsy fkstdghvnq wdfstrrlnf hlletirdnk 121 giiivdstrr gkkipdalsk tvpiwcavln tlmlqetekn vaidkvlylp petvpkseyd 181 mikrkipelv aklqklniid skklnelfmg kllrpiwvhp gsslldhsvd yftgevqeye 241 awetpedqni ipiilctvsy qaqdgmdkry gftyvqgaad dhelwsfgld snmfwahiey 301 lgdasysddq lhdyimdlaa aklrnqcyiq dkgsldevfg nidkitneis lgkvssglti 361 nknlkqklks eygkviifsn svtvaedtdd eeesgtdpfi siyklqsgdk ksskalrstf 421 prihgeiqsl ftnrdekikp mliccntgtd msigvilsil ctkyteewml tselpdiskl 481 ivrkhltkli shlkgrnvnp sratlnsvns flm // LOCUS NP_014011 602 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent DNA helicase YKU70 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014011 VERSION NP_014011.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182791.1 REFERENCE 1 (residues 1 to 602) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 602) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 602) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 602) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10185. Method: conceptual translation. FEATURES Location/Qualifiers source 1..602 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..602 /product="ATP-dependent DNA helicase YKU70" /EC_number="3.6.4.12" /calculated_mol_wt="70517" Region 31..267 /region_name="Ku_N" /note="Ku70/Ku80 N-terminal alpha/beta domain; pfam03731" /db_xref="CDD:427470" Site order(70,73,75,106,108,255..256,258..260) /site_type="active" /note="interface residues [active]" /db_xref="CDD:238735" Region 265..553 /region_name="KU70" /note="Ku-core domain, Ku70 subfamily; Ku70 is a subunit of the Ku protein, which plays a key role in multiple nuclear processes such as DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. The mechanism underlying the...; cd00788" /db_xref="CDD:238407" Site order(265..269,288,291,295,298,316,353,422) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238407" Site order(280,288,291..293,298..302,306..307,312..315,317..319, 330..332,334..337,340..341,343..344,348,352,359,366, 368..369,376,380,388,398..399,407,411,416,418,437,445, 450..456,464,471..472,476,480,487..488,494,499..501,505, 510,512,514,524,527..528,530,550,553) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:238407" CDS 1..602 /gene="YKU70" /locus_tag="YMR284W" /gene_synonym="HDF1; NES24" /coded_by="NM_001182791.1:1..1809" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:10638763]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:11553718]" /experiment="EXISTENCE:direct assay:GO:0043564 Ku70:Ku80 complex [PMID:8754818]" /experiment="EXISTENCE:direct assay:GO:0070034 telomerase RNA binding [PMID:12975323]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:10818099|PMID:8604297]" /experiment="EXISTENCE:genetic interaction:GO:0000727 double-strand break repair via break-induced replication [PMID:17321803]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:18791224]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:9501103|PMID:8604297|PMID:10818099]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:11016833]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:17321803]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:9501103|PMID:10908335]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:18791224]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:9501103|PMID:26587833]" /experiment="EXISTENCE:mutant phenotype:GO:0097552 mitochondrial double-strand break repair via homologous recombination [PMID:22214610]" /experiment="EXISTENCE:mutant phenotype:GO:0097695 establishment of protein-containing complex localization to telomere [PMID:15531893]" /note="Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair" /db_xref="GeneID:855328" /db_xref="SGD:S000004897" ORIGIN 1 mrsvtnafgn sgelndqvde tgyrkfdihe gilfcielse tmfkessdle yksplleile 61 sldelmsqlv itrpgtaigc yfyycnreda kegiyelfpl rdinatfmkk lndlledlss 121 grislydyfm fqqtgsekqv rlsvlftfml dtfleeipgq kqlsnkrvfl ftdidkpqea 181 qdiderarlr rltidlfdnk vnfatffigy adkpfdnefy sdilqlgsht nentgldsef 241 dgpstkpida kyiksrilrk kevkrimfqc plildektnf ivgvkgytmy thekagvryk 301 lvyehedirq eayskrkfln pitgedvtgk tvkvypygdl dinlsdsqdq ivmeaytqkd 361 aflkiigfrs ssksihyfnn idkssfivpd eakyegsirt lasllkilrk kdkiailwgk 421 lksnshpsly tlspssvkdy negfylyrvp fldeirkfps llsyddgseh kldydnmkkv 481 tqsimgyfnl rdgynpsdfk npllqkhykv lhdyllqiet tfdenetpnt kkdrmmredd 541 slrklyyirn kileseksed piiqrlnkyv kiwnmfykkf nddnisikee kkpfdkkpkf 601 ni // LOCUS NP_014012 515 aa linear PLN 30-JUN-2025 DEFINITION RNA exonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_014012 VERSION NP_014012.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182792.1 REFERENCE 1 (residues 1 to 515) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 515) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 515) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 515) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10186. Method: conceptual translation. FEATURES Location/Qualifiers source 1..515 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..515 /product="RNA exonuclease" /calculated_mol_wt="59409" Region 82..515 /region_name="CCR4" /note="mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]; COG5239" /db_xref="CDD:227564" CDS 1..515 /gene="NGL2" /locus_tag="YMR285C" /coded_by="NM_001182792.1:1..1548" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:12358428]" /experiment="EXISTENCE:mutant phenotype:GO:0004521 RNA endonuclease activity [PMID:12358428]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12358428]" /note="Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication" /db_xref="GeneID:855329" /db_xref="SGD:S000004898" ORIGIN 1 mtqdkevkvv apdvapdqev einksvkdak hqtnddsllq hkkkgkkgkk skpivtpehi 61 akvraerevm rkakrdamla qgvdpdcppe lhfirrpfls lheaepvtgf rfklmtyncl 121 aqalirrklf pdsgdalkwy rrskvllnef kyynsdvicl qeidhiqfqs fwkdefsklg 181 ydgqyyrnat knhgvaimwr relfhqvdkm lidydkesse sistrtttnn vglvlalkfs 241 ekvlsnlgkk sskkcgilig tthlfwhpfg tyertrqcyi vlkkmkefmh rvnvlqnend 301 gdlshwfpff cgdfnsqpfd tpylsmtskp vhyrnraktv igcstsykfs kvrdgeegad 361 deeggnieky gkdqpespvp ekfhaneeqs elvdkmaqlh nsldmraisl ysvgyknvhp 421 enagldndrg epeisnwant wrglldylfy vkkwdpqsnc qevetlgdfe kenkvkcrgf 481 lrmppgnemt khgqphvgey asdhlsmvcd lelql // LOCUS NP_014013 86 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL30m MRPL33 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014013 VERSION NP_014013.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182793.1 REFERENCE 1 (residues 1 to 86) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 86) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 86) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 86) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10187. Method: conceptual translation. FEATURES Location/Qualifiers source 1..86 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..86 /product="mitochondrial 54S ribosomal protein uL30m MRPL33" /calculated_mol_wt="9400" Region 4..57 /region_name="Ribosomal_L30" /note="Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; cd01658" /db_xref="CDD:100100" Site order(10..11,13..14,16..18,21..22,25..27,29,32,37..38, 41..43,45..46) /site_type="other" /note="23S rRNA binding site [nucleotide binding]" /db_xref="CDD:100100" CDS 1..86 /gene="MRPL33" /locus_tag="YMR286W" /gene_synonym="uL30m" /coded_by="NM_001182793.1:1..261" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:2060626]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:2060626]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:855330" /db_xref="SGD:S000004899" ORIGIN 1 mvfykvtlsr sligvphttk sivkslglgk rgsivykkvn paiagslakv kelvkvevte 61 heltpsqqre lrksnpgfiv ekrtid // LOCUS NP_014014 969 aa linear PLN 30-JUN-2025 DEFINITION exoribonuclease II [Saccharomyces cerevisiae S288C]. ACCESSION NP_014014 VERSION NP_014014.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182794.1 REFERENCE 1 (residues 1 to 969) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 969) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 969) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 969) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 969) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 969) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 969) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10188. Method: conceptual translation. FEATURES Location/Qualifiers source 1..969 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..969 /product="exoribonuclease II" /EC_number="3.1.13.1" /calculated_mol_wt="110691" Region 522..852 /region_name="RNB" /note="RNB domain; pfam00773" /db_xref="CDD:459934" CDS 1..969 /gene="DSS1" /locus_tag="YMR287C" /gene_synonym="MSU1" /coded_by="NM_001182794.1:1..2910" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0008859 exoribonuclease II activity [PMID:17658549|PMID:12426313]" /experiment="EXISTENCE:direct assay:GO:0045025 mitochondrial degradosome [PMID:12426313]" /experiment="EXISTENCE:mutant phenotype:GO:0000957 mitochondrial RNA catabolic process [PMID:9829834|PMID:12426313]" /note="3'-5' exoribonuclease; component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs" /db_xref="GeneID:855331" /db_xref="SGD:S000004900" ORIGIN 1 mvvrrkvhvl liarsfhsyt pcfrvttrgk rqrskskqqa kveldhtrel dndqatetvv 61 drsvgpekdi esinkdflqr tkglepdiel kqlpqikqef nqrykdryvk psedwyvnsw 121 rsltkpkipl yklinsdfql itklkapnpm efqpvqlmes plnvgdfvll kmrpnelamc 181 vslpsstmdp rytfvtidgt mcfatknrvl lriphklpag ihsliqpesh hkhlpigtvk 241 nfsnqtnilp ivarqlitsr ypaqisklaw kdlpittkkl qllhrslqny mgpwqipfft 301 lvglvqkldl nkalddkngi nyltslvnny htvndipins ptfvstywai mqqqesnlwg 361 eihlntalls pisvtiiplk sqhlyyaqvi ekleansyre vnkfvklvne rkyrdisaly 421 psviqllkdf aagnfhnngi ivaliskifr kierykdcdi trdicqdlin eitpnsipnp 481 lllnmdlalp assklvkwqq klydltniee lqwkksgtdd drydfgdlrv fcidsetahe 541 iddgvsvkny grdglytlyi hiadptsmfp estnvdiegi stdilnvalk rsfttylpdt 601 vvpmlpqsic hlsdlgkqgq rtktisfsvd vkitskcsgk sieimydsfk irkgivsnfp 661 katyedvdri lgtpnseasp vkkdleslsm iskllreqri knsnavifge gfnkglvmln 721 adsegeltev tfsdqeetls tilvsemmil antltgryfa enkiggvfrc ykqlplgeva 781 qqqydsmits tkkgifpklk divklsslln ssfytgrpfr hemigakqyl tvtsplrrfp 841 dlinhlqihr hlqkkplcfn qtqidsliwp iqsradilkr asrnsstywt lnylkkltkl 901 epertfdvmv tsvpqngftg cvfpdlsfar gtlklhpssm hypmigdivk nckiskidcl 961 egmlelekl // LOCUS NP_014015 971 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit HSH155 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014015 VERSION NP_014015.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182795.1 REFERENCE 1 (residues 1 to 971) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 971) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 971) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 971) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 971) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10189. Method: conceptual translation. FEATURES Location/Qualifiers source 1..971 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..971 /product="U2 snRNP complex subunit HSH155" /calculated_mol_wt="109897" Region 1..971 /region_name="HSH155" /note="U2 snRNP spliceosome subunit [RNA processing and modification]; COG5181" /db_xref="CDD:227508" Region 279..303 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 313..342 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 352..383 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 519..543 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(535..536,539,542..543,577..578,581,584..585,588, 618..619,622,625..626,629,660..661,667,670..671,702..703, 706,709..710) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 561..588 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 600..630 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 642..671 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 682..711 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 727..755 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(744..745,748,751..752,755,779..780,783,786..787,790, 814..815,818,821..822,855..856,859,862..863) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 761..791 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 797..822 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 835..864 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..971 /gene="HSH155" /locus_tag="YMR288W" /coded_by="NM_001182795.1:1..2916" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:12773561]" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:15565172|PMID:16314500]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:physical interaction:GO:0000245 spliceosomal complex assembly [PMID:10688664]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16314500]" /note="U2-snRNP associated splicing factor; forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155" /db_xref="GeneID:855332" /db_xref="SGD:S000004901" ORIGIN 1 mshpiqfvna nnsdkshqlg gqysipqdlr enlqkeaari genekdvlqe kmetrtvqnr 61 edsyhkrrfd mkfepdsdtq tvtssentqd avvprkrksr wdvkgyeppd esstavkens 121 dsalvnvegi hdlmffkpsd hkyfadvisk kpidelnkde kkertlsmll lkikngntas 181 rrtsmriltd kavtfgpemi fnrllpilld rsledqerhl miktidrvly qlgdltkpyv 241 hkilvvaapl lidedpmvrs tgqeiitnls tvaglktilt vmrpdiened eyvrnvtsra 301 aavvakalgv nqllpfinaa chsrkswkar htgikivqqi gillgigvln hltglmscik 361 dclmddhvpv rivtahtlst laensypygi evfnvvlepl wkgirshrgk vlssflkavg 421 smiplmdpey agyytteamr iirrefdspd demkktillv lqkcsavesi tpkflreeia 481 peffqkfwvr rvaldrplnk vvtyttvtla kklgcsytid klltplrdea epfrtmavha 541 vtrtvnllgt adlderletr lidalliafq eqtnsdsiif kgfgavtvsl dirmkpflap 601 ivstilnhlk hktplvrqha adlcailipv iknchefeml nklniilyes lgevypevlg 661 siinamycit svmdldklqp pinqilptlt pilrnkhrkv evntikfvgl igklaptyap 721 pkewmricfe llellkstnk eirrsanatf gfiaeaigph dvlvallnnl kvqerqlrvc 781 tavaigivak vcgpynvlpv imneyttpet nvqngvlkam sfmfeyignm skdyiyfitp 841 lledaltdrd lvhrqtasnv ithlalncsg tghedafihl mnllipnife tsphaimril 901 eglealsqal gpglfmnyiw aglfhpaknv rkafwrvynn myvmyqdamv pfypvtpdnn 961 eeyieeldlv l // LOCUS NP_014016 374 aa linear PLN 30-JUN-2025 DEFINITION aminodeoxychorismate lyase ABZ2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014016 VERSION NP_014016.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182796.1 REFERENCE 1 (residues 1 to 374) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 374) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 374) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 374) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10190. Method: conceptual translation. FEATURES Location/Qualifiers source 1..374 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..374 /product="aminodeoxychorismate lyase ABZ2" /EC_number="4.1.3.38" /calculated_mol_wt="42509" Region 118..366 /region_name="PLPDE_IV" /note="PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; cl00224" /db_xref="CDD:444764" CDS 1..374 /gene="ABZ2" /locus_tag="YMR289W" /coded_by="NM_001182796.1:1..1125" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008696 4-amino-4-deoxychorismate lyase activity [PMID:17873082]" /experiment="EXISTENCE:mutant phenotype:GO:0046656 folic acid biosynthetic process [PMID:17873082]" /note="Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase); catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis" /db_xref="GeneID:855333" /db_xref="SGD:S000004902" ORIGIN 1 mslmdnwktd mesydegglv anpnfevlat frydpgfarq saskkeifet pdprlglrde 61 dirqqiined yssylrvrev nsggdlleni qhpdawkhdc ktivcqrved mlqviyerff 121 lldeqyqrir ialsyfkidf stslndllkl lvenlincke gnseyhekiq kminerqcyk 181 mrvlvsktgd irieaipmpm epilklttdy dsvstyfikt mlngflidst inwdvvvsse 241 plnasaftsf kttsrdhyar arvrmqtain nlrgseptss vsqceilfsn ksgllmegsi 301 tnvaviqkdp ngskkyvtpr latgclcgtm rhyllrlgli eegdidigsl tvgnevllfn 361 gvmgcikgtv ktky // LOCUS NP_014017 505 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase HAS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014017 VERSION NP_014017.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182797.1 REFERENCE 1 (residues 1 to 505) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 505) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 505) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 505) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10191. Method: conceptual translation. FEATURES Location/Qualifiers source 1..505 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..505 /product="ATP-dependent RNA helicase HAS1" /EC_number="3.6.4.13" /calculated_mol_wt="56587" Region 44..>474 /region_name="PRK11634" /note="ATP-dependent RNA helicase DeaD; Provisional" /db_xref="CDD:236941" Region 53..251 /region_name="DEADc_DDX18" /note="DEAD-box helicase domain of DEAD box protein 18; cd17942" /db_xref="CDD:350700" Site order(61..62,64..66,69,87..94) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350700" CDS 1..505 /gene="HAS1" /locus_tag="YMR290C" /coded_by="NM_001182797.1:1..1518" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:15718299]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:15718299]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247|PMID:15049817]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:15718299]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:11583614]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15049817]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:23788678]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:15242642]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:23788678|PMID:15049817]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:23788678|PMID:15049817]" /experiment="EXISTENCE:mutant phenotype:GO:1990417 snoRNA release from pre-rRNA [PMID:16908538]" /note="ATP-dependent RNA helicase; involved in the biogenesis of 40S and 60S ribosome subunits; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles" /db_xref="GeneID:855335" /db_xref="SGD:S000004903" ORIGIN 1 matpsnkrsr dsesteepvv dekstskqnn aapegeqttc vekfeelkls qptlkaiekm 61 gfttmtsvqa rtippllagr dvlgaaktgs gktlaflipa iellhslkfk prngtgiivi 121 tptrelalqi fgvarelmef hsqtfgivig ganrrqeaek lmkgvnmlia tpgrlldhlq 181 ntkgfvfknl kaliideadr ileigfedem rqiikilpne drqsmlfsat qttkvedlar 241 islrpgplfi nvvpetdnst adgleqgyvv cdsdkrflll fsflkrnqkk kiivflsscn 301 svkyyaelln yidlpvlelh gkqkqqkrtn tffefcnaer gilictdvaa rgldipavdw 361 iiqfdppddp rdyihrvgrt argtkgkgks lmfltpnelg flrylkaskv plneyefpen 421 kianvqsqle kliksnyylh qtakdgyrsy lqayashslk tvyqidkldl akvaksygfp 481 vppkvnitig asgktpntkr rkthk // LOCUS NP_014019 586 aa linear PLN 30-JUN-2025 DEFINITION protein kinase TDA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014019 VERSION NP_014019.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182799.1 REFERENCE 1 (residues 1 to 586) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 586) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 586) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 586) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10192. Method: conceptual translation. FEATURES Location/Qualifiers source 1..586 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..586 /product="protein kinase TDA1" /EC_number="2.7.11.1" /calculated_mol_wt="66089" Region 37..350 /region_name="STKc_CAMK" /note="The catalytic domain of CAMK family Serine/Threonine Kinases; cd05117" /db_xref="CDD:270687" Site order(45..49,53,66,68,117,133..136,140,142,179..180,182, 184..185,187,219..220,223,239..243,245) /site_type="active" /db_xref="CDD:270687" Site order(45..48,53,66,68,117,133..136,140,184..185,187, 219..220) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270687" Site order(49,140,142,179..180,182,184,223,239..243,245) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270687" Site order(219..227,239..243) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270687" CDS 1..586 /gene="TDA1" /locus_tag="YMR291W" /coded_by="NM_001182799.1:1..1761" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22289182]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22289182]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:25593311]" /experiment="EXISTENCE:mutant phenotype:GO:0018105 peptidyl-serine phosphorylation [PMID:22289182|PMID:25593311]" /experiment="EXISTENCE:mutant phenotype:GO:1904547 regulation of cellular response to glucose starvation [PMID:40275108]" /note="Protein serine/threonine kinase; negative regulator of glucose starvation signaling pathway; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene; relocalizes from nucleus to cytoplasm upon DNA replication stress" /db_xref="GeneID:855336" /db_xref="SGD:S000004905" ORIGIN 1 mttasssasq lqqrlpeekp wpqlsgsnad aqtfkckyvt nhnslgdgnf svvkecmnih 61 tkdlyamkli kkqtvknkiq liqrefdllr sisekirdme kknehsldif eghhhilqlf 121 dyfetadniv litqlcqkgd lyekivenqc ldletqvtsy caclvsvlef lhsqgivhrd 181 lkaenvlfrl rvneneknlq gehhgdfkyd llahdlvlad fglaaeynts kvnslkefvg 241 tisyiapeiv kckgvgemtp dqvgkldkyg cpvdiwalgv ltyfmafgyt pfdcttddet 301 leciskcdyy vdeqmmhdpk yeqfwnfvqc cftidpavrr saknlkqhpf ikdyfatsns 361 lntkdtpnfs fhptirrvss tasmhtlrsp sksrktttla ylnmdggsse tstafsskmd 421 lpdlyvdrti nsrerslnri rdtlkktlsm tslkpagtfd ylhankngts lsssksglvk 481 knstfvldpk ppknslmngc fsttpesrsn fntpktlsrq gsstsvkkyv nevdllltpr 541 tasmssndtt aindydttnd knparkhaas fqvnvddsdg detmqi // LOCUS NP_014020 138 aa linear PLN 30-JUN-2025 DEFINITION Got1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014020 VERSION NP_014020.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182800.1 REFERENCE 1 (residues 1 to 138) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 138) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 138) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 138) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 138) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10193. Method: conceptual translation. FEATURES Location/Qualifiers source 1..138 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..138 /product="Got1p" /calculated_mol_wt="15300" Region 1..138 /region_name="GOT1" /note="Membrane protein involved in Golgi transport [Intracellular trafficking and secretion]; COG5120" /db_xref="CDD:227450" CDS 1..138 /gene="GOT1" /locus_tag="YMR292W" /coded_by="NM_001182800.1:1..417" /experiment="EXISTENCE:direct assay:GO:0000137 Golgi cis cisterna [PMID:10406798]" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:10406798]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:19383723]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:19383723]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:19383723]" /experiment="EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:10406798]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10406798|PMID:19383723]" /note="Homodimeric protein that is packaged into COPII vesicles; cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition" /db_xref="GeneID:855337" /db_xref="SGD:S000004906" ORIGIN 1 mwlteaqkfg vaftfggflf flfgiftffd rallalgnil fligvfliig sqktyifftr 61 pnkrrgslff lvgaflillk wtflgfiies lgiiglfgdf fgvivqflrs mpiigpilsh 121 paiapivdkl agvrvlpv // LOCUS NP_014021 464 aa linear PLN 30-JUN-2025 DEFINITION glutamyl-tRNA(Gln) amidotransferase subunit HER2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014021 VERSION NP_014021.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182801.1 REFERENCE 1 (residues 1 to 464) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 464) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 464) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 464) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10194. Method: conceptual translation. FEATURES Location/Qualifiers source 1..464 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..464 /product="glutamyl-tRNA(Gln) amidotransferase subunit HER2" /EC_number="6.3.5.7" /calculated_mol_wt="50788" Region 1..464 /region_name="gatA" /note="aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit; TIGR00132" /db_xref="CDD:272925" CDS 1..464 /gene="HER2" /locus_tag="YMR293C" /gene_synonym="GEP6; QRS1; RRG6" /coded_by="NM_001182801.1:1..1395" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19417106|PMID:14576278|PMID:14562095|PMID:16823961|P MID:11914276]" /experiment="EXISTENCE:direct assay:GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex [PMID:19417106]" /experiment="EXISTENCE:direct assay:GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity [PMID:19417106]" /experiment="EXISTENCE:direct assay:GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation [PMID:19417106]" /experiment="EXISTENCE:genetic interaction:GO:0007029 endoplasmic reticulum organization [PMID:18667535]" /note="Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase" /db_xref="GeneID:855338" /db_xref="SGD:S000004907" ORIGIN 1 mplkrslkes ierlssfqsk yniftsinps pysitnkkgt ketltgcvas ikdnivtkdf 61 pttcashile nfkspfdatv vkllkqagvh ilgktnldef gmgsggvhsi rgpvinplyp 121 hedkkimggs ssgaaasvac dlvdfalgtd tggsvrlpac ygsvlgfkps ygrlsrfgvi 181 aysqsldtvg ilskkinvlr kvfhtldkyd mkdptslsve lreliegnkk vrrplkvgiv 241 kefshesmpi gfhrlylsll eklinlglei ypvsipsvkn clpiyytlsp aeaasnlsry 301 dgirygyrds eldikdgilf aptrskfgte vknriilgny nlcsdafknn fikaeklrvn 361 lidefdgifr fpnvltnskg npdgldlliv ptssklpgsi rdfeeeeaks pansyindvf 421 tvpmslaglp slsmplkekt piglqvvgqy gddstvldfv esis // LOCUS NP_014022 373 aa linear PLN 30-JUN-2025 DEFINITION Jnm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014022 VERSION NP_014022.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182802.1 REFERENCE 1 (residues 1 to 373) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 373) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 373) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 373) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10195. Method: conceptual translation. FEATURES Location/Qualifiers source 1..373 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..373 /product="Jnm1p" /calculated_mol_wt="43476" Region <175..363 /region_name="Dynamitin" /note="pfam04912" /db_xref="CDD:461477" CDS 1..373 /gene="JNM1" /locus_tag="YMR294W" /gene_synonym="INS1; PAC3" /coded_by="NM_001182802.1:1..1122" /experiment="EXISTENCE:direct assay:GO:0005200 structural constituent of cytoskeleton [PMID:9658168]" /experiment="EXISTENCE:direct assay:GO:0005869 dynactin complex [PMID:9658168]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:8138567]" /experiment="EXISTENCE:mutant phenotype:GO:0007097 nuclear migration [PMID:8138567]" /note="Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B" /db_xref="GeneID:855339" /db_xref="SGD:S000004908" ORIGIN 1 mnvidlsdpa invdydslig idneesqeif enevkedgqq eeqeeassrk dglivepgrd 61 veslrraird qllfkihrqn qsdcadarkl sndeedesrq qklerireel eelkienlts 121 emqteikelc eiqsklates ssrltnlrkk lletyegqdt vilpniildt snikrlqkld 181 qkislmerfv gipealeaee drksvhskvn elyrsiqllq gddkaegklq kfrdrlveln 241 eefensllgk kiqqdlrlkd dtvsklvmpe nkvkeinsmy smfkqyqdsl pllaermksl 301 nkmnnrviev yettkgldsq itsiqeqgkv wlkalneldk kfdeqevkir enmeqirrki 361 dtledealqr nsk // LOCUS NP_014024 197 aa linear PLN 30-JUN-2025 DEFINITION Gsr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014024 VERSION NP_014024.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182804.1 REFERENCE 1 (residues 1 to 197) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 197) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 197) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10196. Method: conceptual translation. FEATURES Location/Qualifiers source 1..197 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..197 /product="Gsr1p" /calculated_mol_wt="22048" Region 49..116 /region_name="DUF2406" /note="Uncharacterized protein (DUF2406); pfam10295" /db_xref="CDD:402077" CDS 1..197 /gene="GSR1" /locus_tag="YMR295C" /coded_by="NM_001182804.1:1..594" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:38452761|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:38452761]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:38452761]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:38452761]" /experiment="EXISTENCE:genetic interaction:GO:0090334 regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [PMID:38452761]" /experiment="EXISTENCE:physical interaction:GO:0090334 regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [PMID:38452761]" /note="Putative regulator of 1,3-beta-glucan biosynthesis; interacts with the catalytic (Fks1p and Gsc2p) and regulatory subunits (Rho1p) of 1,3-beta-glucan synthase; has a negative genetic interaction with RHO1; localizes to the cell periphery during early G1, to the bud tip in late G1, to the bud at S/G2, to the periphery of the bud at metaphase and at the bud neck during telophase; periodically expressed during the cell cycle; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855341" /db_xref="SGD:S000004910" ORIGIN 1 mmhfrkkssi sntsdhdgan rasdvkised dkarlkmrta svadpildav qeaqpfeqaa 61 dtfhdnmnrq syfsneeghv lcdvfgqpit qadisnptra rderpldtir sfeyavsgdp 121 vwaqqletpt ygfrvrpdfp vfgaavtyda ngmpqqvgga ssqmygeqav yqpqqhvqte 181 ekqkkkkkgl fgrmkkk // LOCUS NP_014025 558 aa linear PLN 30-JUN-2025 DEFINITION serine C-palmitoyltransferase LCB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014025 VERSION NP_014025.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182805.1 REFERENCE 1 (residues 1 to 558) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 558) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 558) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 558) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10197. Method: conceptual translation. FEATURES Location/Qualifiers source 1..558 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..558 /product="serine C-palmitoyltransferase LCB1" /EC_number="2.3.1.50" /calculated_mol_wt="62076" Region 62..547 /region_name="AAT_I" /note="Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl18945" /db_xref="CDD:450240" Site order(214..215,218,291,320,323,353,356) /site_type="other" /note="pyridoxal 5'-phosphate binding pocket [chemical binding]" /db_xref="CDD:99742" Site 356 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99742" CDS 1..558 /gene="LCB1" /locus_tag="YMR296C" /gene_synonym="END8; TSC2" /coded_by="NM_001182805.1:1..1677" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:1556076|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0017059 serine palmitoyltransferase complex [PMID:20182505]" /experiment="EXISTENCE:mutant phenotype:GO:0004758 serine C-palmitoyltransferase activity [PMID:1556076|PMID:8058731]" /experiment="EXISTENCE:mutant phenotype:GO:0017059 serine palmitoyltransferase complex [PMID:8058731]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:1556075]" /note="Component of serine palmitoyltransferase; responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine" /db_xref="GeneID:855342" /db_xref="SGD:S000004911" ORIGIN 1 mahipevlpk sipipafivt tssylwyyfn lvltqipggq fivsyikksh hddpyrttve 61 iglilygiiy ylskpqqkks lqaqkpnlsp qeidaliedw epeplvdpsa tdeqswrvak 121 tpvtmempiq nhititrnnl qekytnvfnl asnnflqlsa tepvkevvkt tiknygvgac 181 gpagfygnqd vhytleydla qffgtqgsvl ygqdfcaaps vlpaftkrgd vivaddqvsl 241 pvqnalqlsr stvyyfnhnd mnslecllne lteqeklekl paiprkfivt egifhnsgdl 301 aplpeltklk nkykfrlfvd etfsigvlga tgrglsehfn mdrataidit vgsmatalgs 361 tggfvlgdsv mclhqrigsn aycfsaclpa ytvtsvskvl klmdsnndav qtlqklsksl 421 hdsfasddsl rsyvivtssp vsavlhlqlt payrsrkfgy tceqlfetms alqkksqtnk 481 fiepyeeeek flqsivdhal inynvlitrn tivlkqetlp ivpslkiccn aamspeelkn 541 acesvkqsil accqesnk // LOCUS NP_014026 532 aa linear PLN 30-JUN-2025 DEFINITION carboxypeptidase C PRC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014026 VERSION NP_014026.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182806.1 REFERENCE 1 (residues 1 to 532) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 532) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 532) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 532) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 532) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10198. Method: conceptual translation. FEATURES Location/Qualifiers source 1..532 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..532 /product="carboxypeptidase C PRC1" /EC_number="3.4.16.5" /calculated_mol_wt="59671" Region 1..106 /region_name="Carbpep_Y_N" /note="Carboxypeptidase Y pro-peptide; pfam05388" /db_xref="CDD:398840" Region 119..528 /region_name="Peptidase_S10" /note="Serine carboxypeptidase; pfam00450" /db_xref="CDD:459815" CDS 1..532 /gene="PRC1" /locus_tag="YMR297W" /gene_synonym="CPY1; LBC1" /coded_by="NM_001182806.1:1..1599" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:29514932]" /experiment="EXISTENCE:direct assay:GO:0004185 serine-type carboxypeptidase activity [PMID:8679540]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0046938 phytochelatin biosynthetic process [PMID:17408619]" /experiment="EXISTENCE:genetic interaction:GO:0004185 serine-type carboxypeptidase activity [PMID:29514932]" /experiment="EXISTENCE:genetic interaction:GO:0005775 vacuolar lumen [PMID:29514932]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:29514932]" /experiment="EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:29514932]" /experiment="EXISTENCE:genetic interaction:GO:0031638 zymogen activation [PMID:29514932]" /experiment="EXISTENCE:mutant phenotype:GO:0004185 serine-type carboxypeptidase activity [PMID:8679540|PMID:29514932]" /experiment="EXISTENCE:mutant phenotype:GO:0005775 vacuolar lumen [PMID:29514932]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:29514932]" /experiment="EXISTENCE:mutant phenotype:GO:0046938 phytochelatin biosynthetic process [PMID:17408619]" /note="Vacuolar carboxypeptidase Y (proteinase C, CPY); broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in vacuole; involved, along with functional homolog Prc1p, in vacuolar zymogen activation, breakdown of autophagic body, and autophagosome-dependent protein synthesis; role in phytochelatin synthesis; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; member of serine carboxypeptidase family; N-glycosylated" /db_xref="GeneID:855343" /db_xref="SGD:S000004912" ORIGIN 1 mkaftsllcg lglsttlaka islqrplgld kdvllqaaek fgldldldhl lkeldsnvld 61 awaqiehlyp nqvmsletst kpkfpeaikt kkdwdfvvkn daienyqlrv nkikdpkilg 121 idpnvtqytg yldvededkh fffwtfesrn dpakdpvilw lnggpgcssl tglffelgps 181 sigpdlkpig npyswnsnat vifldqpvnv gfsysgssgv sntvaagkdv ynflelffdq 241 fpeyvnkgqd fhiagesyag hyipvfasei lshkdrnfnl tsvlignglt dpltqynyye 301 pmacgeggep svlpseecsa medslerclg liescydsqs vwscvpatiy cnnaqlapyq 361 rtgrnvydir kdceggnlcy ptlqdiddyl nqdyvkeavg aevdhyescn fdinrnflfa 421 gdwmkpyhta vtdllnqdlp ilvyagdkdf icnwlgnkaw tdvlpwkyde efasqkvrnw 481 tasitdevag evksykhfty lrvfngghmv pfdvpenals mvnewihggf sl // LOCUS NP_014027 150 aa linear PLN 30-JUN-2025 DEFINITION sphingosine N-acyltransferase subunit LIP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014027 VERSION NP_014027.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182807.1 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10199. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..150 /product="sphingosine N-acyltransferase subunit LIP1" /calculated_mol_wt="17076" Region 22..150 /region_name="LIP1-like" /note="ceramide synthase subunit LIP1 and similar proteins; cd24143" /db_xref="CDD:467943" CDS 1..150 /gene="LIP1" /locus_tag="YMR298W" /coded_by="NM_001182807.1:1..453" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14690591|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:15692566]" /experiment="EXISTENCE:direct assay:GO:0061576 acyl-CoA ceramide synthase complex [PMID:15692566]" /experiment="EXISTENCE:mutant phenotype:GO:0046513 ceramide biosynthetic process [PMID:15692566]" /experiment="EXISTENCE:mutant phenotype:GO:0050291 sphingosine N-acyltransferase activity [PMID:15692566]" /experiment="EXISTENCE:physical interaction:GO:0046513 ceramide biosynthetic process [PMID:15692566]" /note="Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis" /db_xref="GeneID:855344" /db_xref="SGD:S000004913" ORIGIN 1 msqptpiitt ksaakpkpki fnlfrvcfis llliaaveyf kygtrinyew fhctpikepq 61 sgsviklwar ggpscdkrge yktivkritr dyepndehls fciiendnvp pvhypihedk 121 gepgyvayvg ydtdselvqe lcadstiyhm // LOCUS NP_014028 312 aa linear PLN 30-JUN-2025 DEFINITION dynein light intermediate chain [Saccharomyces cerevisiae S288C]. ACCESSION NP_014028 VERSION NP_014028.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182808.2 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10200. On Apr 26, 2011 this sequence version replaced NP_014028.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..312 /product="dynein light intermediate chain" /calculated_mol_wt="36694" Region <163..>301 /region_name="DLIC" /note="Dynein light intermediate chain (DLIC); pfam05783" /db_xref="CDD:368612" CDS 1..312 /gene="DYN3" /locus_tag="YMR299C" /coded_by="NM_001182808.2:1..939" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:14764870|PMID:15642746]" /experiment="EXISTENCE:mutant phenotype:GO:0003774 cytoskeletal motor activity [PMID:15642746]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:15642746|PMID:14764870]" /experiment="EXISTENCE:physical interaction:GO:0005868 cytoplasmic dynein complex [PMID:15642746]" /note="Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration" /db_xref="GeneID:855345" /db_xref="SGD:S000004914" ORIGIN 1 mdncnawdkl lsqnestins tetatitaii yspssktlhq finicfpegs nsildttlin 61 yatigwtndl kenysvdvyt lirntddald llkpflqehs skvrwlilld wtlndqklwl 121 nelsyafnki kqlnddnefs vwclnsgeil nlqrhttvwq svhidfilqt lrsfcyfnds 181 slfyicedht eekreeaqrl kyqellkhfc edrdmkdhie mvkrseilip kgcdsiglik 241 tvderfepte vkeqhflary mdfiptidki redrkttsgi dldklyplev fkvniqeelg 301 kmfakyrens ri // LOCUS NP_014029 510 aa linear PLN 30-JUN-2025 DEFINITION amidophosphoribosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014029 VERSION NP_014029.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182809.1 REFERENCE 1 (residues 1 to 510) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 510) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 510) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 510) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 510) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10201. Method: conceptual translation. FEATURES Location/Qualifiers source 1..510 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..510 /product="amidophosphoribosyltransferase" /EC_number="2.4.2.14" /calculated_mol_wt="56588" Region 1..486 /region_name="PurF" /note="Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; COG0034" /db_xref="CDD:439804" CDS 1..510 /gene="ADE4" /locus_tag="YMR300C" /coded_by="NM_001182809.1:1..1533" /experiment="EXISTENCE:direct assay:GO:0004044 amidophosphoribosyltransferase activity [PMID:11689683]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:40208903]" /experiment="EXISTENCE:mutant phenotype:GO:0004044 amidophosphoribosyltransferase activity [PMID:6376509|PMID:11689683]" /experiment="EXISTENCE:mutant phenotype:GO:0006189 'de novo' IMP biosynthetic process [PMID:11689683]" /note="Phosphoribosylpyrophosphate amidotransferase (PRPPAT); catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway; forms TORC1-dependent, dynamic and motile condensates in cells under a purine-depleted environment facilitates efficient de novo purine synthesis; also known as amidophosphoribosyltransferase" /db_xref="GeneID:855346" /db_xref="SGD:S000004915" ORIGIN 1 mcgilgivla nqttpvapel cdgciflqhr gqdaagiatc gsrgriyqck gngmardvft 61 qqrvsglags mgiahlrypt agssanseaq pfyvnspygi nlahngnlvn taslkrymde 121 dvhrhintds dselllnifa aelekhnkyr vnnedvfhal egvyrlcrgg yacvgllagf 181 alfgfrdpng irpllfgere npdgtkdyml asesvvfkah nftkyrdlkp geaviipknc 241 skgepefkqv vpinsyrpdl feyvyfarpd svldgisvyh trlamgskla enilkqlkpe 301 didvvipvpd tartcaleca nvlgkpyreg fvknryvgrt fimpnqrerv ssvrrklnpm 361 esefkgkkvl ivddsivrgt tskeivnmak esgatkvyfa saapairynh iygidltdtk 421 nliaynrtde evaevigcer viyqsledli dccktdkitk fedgvftgny vtgvedgyiq 481 eleekresia nnssdmkaev diglyncady // LOCUS NP_014030 690 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette Fe/S cluster precursor transporter ATM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014030 VERSION NP_014030.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182810.1 REFERENCE 1 (residues 1 to 690) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 690) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 690) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 690) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 690) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10202. Method: conceptual translation. FEATURES Location/Qualifiers source 1..690 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..690 /product="ATP-binding cassette Fe/S cluster precursor transporter ATM1" /calculated_mol_wt="77391" Region 81..674 /region_name="ATM1" /note="ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; COG5265" /db_xref="CDD:444078" CDS 1..690 /gene="ATM1" /locus_tag="YMR301C" /coded_by="NM_001182810.1:1..2073" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7828591]" /experiment="EXISTENCE:direct assay:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:16754360]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:10406803]" /experiment="EXISTENCE:mutant phenotype:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:7828591]" /experiment="EXISTENCE:mutant phenotype:GO:1902497 iron-sulfur cluster transmembrane transport [PMID:31040179]" /note="Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; human homolog ABCB7 can complement yeast null mutant" /db_xref="GeneID:855347" /db_xref="SGD:S000004916" ORIGIN 1 mlllprcpvi grivrskfrs glirnhspvi ftvsklstqr pllfnsavnl wnqaqkdith 61 kksveqfssa pkvktqvkkt skaptlselk ilkdlfryiw pkgnnkvrir vlialgllis 121 akilnvqvpf ffkqtidsmn iawddptval paaigltilc ygvarfgsvl fgelrnavfa 181 kvaqnairtv slqtfqhlmk ldlgwhlsrq tggltramdr gtkgisqvlt amvfhiipis 241 feisvvcgil tyqfgasfaa itfstmllys iftikttawr thfrrdanka dnkaasvald 301 slinfeavky fnnekyladk yngslmnyrd sqikvsqsla flnsgqnlif ttaltammym 361 gctgviggnl tvgdlvlinq lvfqlsvpln flgsvyrdlk qslidmetlf klrknevkik 421 naerplmlpe nvpyditfen vtfgyhpdrk ilknasftip agwktaivgs sgsgkstilk 481 lvfrfydpes grilingrdi keydidalrk vigvvpqdtp lfndtiwenv kfgridatde 541 evitvvekaq laplikklpq gfdtivgerg lmisggekqr laiarvllkn arimffdeat 601 saldthteqa llrtirdnft sgsrtsvyia hrlrtiadad kiivldngrv reegkhlell 661 ampgslyrel wtiqedldhl enelkdqqel // LOCUS NP_014031 850 aa linear PLN 30-JUN-2025 DEFINITION Yme2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014031 VERSION NP_014031.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182811.1 REFERENCE 1 (residues 1 to 850) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 850) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 850) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 850) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 850) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 850) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 850) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10203. Method: conceptual translation. FEATURES Location/Qualifiers source 1..850 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..850 /product="Yme2p" /calculated_mol_wt="96558" Region 194..276 /region_name="RRM_Yme2p_like" /note="RNA recognition motif (RRM) found in yeast mitochondrial escape protein 2 (Yme2p) and similar proteins; cd12433" /db_xref="CDD:409867" Region 364..814 /region_name="RNA12" /note="RNA12 protein; pfam10443" /db_xref="CDD:371055" CDS 1..850 /gene="YME2" /locus_tag="YMR302C" /gene_synonym="PRP12; RNA12" /coded_by="NM_001182811.1:1..2553" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8649384]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:8514129]" /note="Integral inner mitochondrial membrane protein; role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases" /db_xref="GeneID:855348" /db_xref="SGD:S000004917" ORIGIN 1 mllvrttsln vsrmpvpcla rgigilkgky rlanlmnaqp svrhvsseiq qkdqqagesn 61 tatdtgvihk sdeetliyfd nvyarttsvw nptlwynlll rnqsrdavre kirnlasppn 121 npiyglelks tipvkrdggv fatfvvppky tkaqvnsliq qntaresskn llsyftrasa 181 fpvkgspwie dlrrlpstti vikfqgpalt eeeiyslfrr ygtiidifpp taannnvakv 241 ryrsfrgais akncvsgiei hntvlhiqye nirrghlvsn fftnhtriai pvlfallsif 301 avlvfdpire fsieqkithk yslswdnkfw kqlktltsst mtsikyywgg pddnhqrkhl 361 weeriekvnd lkmwleennn tfvvirgprg sgkhdlvmqh tlqnranvly ldcdkliksr 421 tdpmflknaa sqlgyfpifp widsvtgvld ltvqgltgqk tglsetkesr frnmlttslm 481 sirrialkny kafvstgdgt vnvkeedylq qhpeakpviv idrfegksei ngfvykelsd 541 waamlvqmni ahvifltetv asnqrlsesl pnqvfknlil sdaskensrn yvlsqledyl 601 yynkkskgen vkepeseket aenndsdsea dtsvkkaevi lnekelqeid asleplggrm 661 ldlqafvrrv ksgeepseav dkmieqaseq itqmflsdki dsnksaqawe liellsanpv 721 ipfheivnkp lfkaapetgi melennglit vsrdrgvlqe irpakplyra aftylindpe 781 lakvlktryl lkvvgfetgr ikkweeelkp lgkvpdqklf ktrldylsgk inasnavitk 841 ceeeiknlsk // LOCUS NP_014032 348 aa linear PLN 30-JUN-2025 DEFINITION alcohol dehydrogenase ADH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014032 VERSION NP_014032.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182812.1 REFERENCE 1 (residues 1 to 348) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 348) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 348) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 348) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10204. Method: conceptual translation. FEATURES Location/Qualifiers source 1..348 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..348 /product="alcohol dehydrogenase ADH2" /EC_number="1.1.1.1" /calculated_mol_wt="36601" Region 7..345 /region_name="CAD3" /note="Cinnamyl alcohol dehydrogenases (CAD); cd08297" /db_xref="CDD:176257" Site order(44..46,49,154,158,178,180..181,183,201..202,207, 246..249,252,269..271,294..296,341) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:176257" Site order(44,46,55,67,93,154,271,296) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:176257" Site order(44,67,154) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176257" Site order(55,100,102..103,111..113,169..171,193..195,197,209, 212..213,253,261,263,268,270..271,281..282,287..295, 299..300,304,308,311) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:176257" Site order(98,101,104,112) /site_type="other" /note="structural Zn binding site [ion binding]" /db_xref="CDD:176257" CDS 1..348 /gene="ADH2" /locus_tag="YMR303C" /gene_synonym="ADR2" /coded_by="NM_001182812.1:1..1047" /experiment="EXISTENCE:direct assay:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:3546317]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006067 ethanol metabolic process [PMID:3546317]" /experiment="EXISTENCE:genetic interaction:GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /note="Glucose-repressible alcohol dehydrogenase II; catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1" /db_xref="GeneID:855349" /db_xref="SGD:S000004918" ORIGIN 1 msipetqkai ifyesngkle hkdipvpkpk pnellinvky sgvchtdlha whgdwplptk 61 lplvgghega gvvvgmgenv kgwkigdyag ikwlngscma ceycelgnes ncphadlsgy 121 thdgsfqeya tadavqaahi pqgtdlaeva pilcagitvy kalksanlra ghwaaisgaa 181 gglgslavqy akamgyrvlg idggpgkeel ftslggevfi dftkekdivs avvkatngga 241 hgiinvsvse aaieastryc rangtvvlvg lpagakcssd vfnhvvksis ivgsyvgnra 301 dtrealdffa rglvkspikv vglsslpeiy ekmekgqiag ryvvdtsk // LOCUS NP_014033 1230 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease UBP15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014033 VERSION NP_014033.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182814.1 REFERENCE 1 (residues 1 to 1230) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1230) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1230) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1230) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10205. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1230 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1230 /product="ubiquitin-specific protease UBP15" /EC_number="3.4.19.12" /calculated_mol_wt="143433" Region 1..1229 /region_name="COG5077" /note="Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]" /db_xref="CDD:227409" Site order(209,214,465,483) /site_type="active" /db_xref="CDD:239124" CDS 1..1230 /gene="UBP15" /locus_tag="YMR304W" /coded_by="NM_001182814.1:1..3693" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:21665945|PMID:25877870|PMID:10527495|PMID:21710968]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:21665945]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:21665945]" /experiment="EXISTENCE:direct assay:GO:0010995 free ubiquitin chain depolymerization [PMID:21665945]" /experiment="EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:21665945|PMID:25877870]" /experiment="EXISTENCE:genetic interaction:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:33226341]" /experiment="EXISTENCE:mutant phenotype:GO:0004843 cysteine-type deubiquitinase activity [PMID:21665945]" /experiment="EXISTENCE:mutant phenotype:GO:0010995 free ubiquitin chain depolymerization [PMID:21665945]" /note="Ubiquitin-specific protease involved in protein deubiquitination; forms a complex with AAA peroxins Pex1p and Pex6p; deubiquitinates mono- and polyubiquitinated forms of Pex5p; deubiquitinates Clb5p, counteracting APC activity, and facilitating both Clb5p accumulation and S phase entry; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences" /db_xref="GeneID:855350" /db_xref="SGD:S000004920" ORIGIN 1 mssedelgsi gtvfpgspid ksigsilpqf deevetlled sftwnipdwn eltnpkynsp 61 rfrigdfewd illfpqgnhn kgvavyleph peekldettg emvpvdpdwy ccaqfaigis 121 rpgngdtinl inkshhrfna ldtdwgfanl idlnnlkhps kgrplsflne gtlnitayvr 181 ilkdptgvlw hnflnydskk vtgyvgfrnq gatcylnsll qsyfftkyfr klvyeipteh 241 espnnsvpla lqrafyqlqv sdipldtlel trsfgwdtae sftqhdvqel nrilmdrlen 301 nmkgtpvegk lneifvgkmk syikcinvdy esarvedfwd lqlnvknfkn lqesfdnyie 361 melmngenqy aaqdyglqda qkgvifesfp pvlhlqlkrf eydfnydqmv kvndkyefpe 421 tidlspfvdk dvlkktldse nkdknpyvyn lhgvlvhsgd istghyytli kpgvedqwyr 481 fddervwrvt kkqvfqenfg cdrlpdekvr tmtrgeyqny iiqrhtsaym lvyirqeqee 541 dllrpvlesd vpkhvitrvr eeikeretke keireahlyv tlrlhsikef ihyegfdyfa 601 hdgfrlfaee lndsglqqin lkvlrttkls difasiketm nipqerdvky wkmdyrrnst 661 lrltqpinfe svnitlqeal kkekkrtmqt qygeegvast eeddkallet vsfldlfiee 721 pylelqflnk lkeasliska qlddelisti rtnlpeltkg giepvfatdn ksnllfvksy 781 dphtqkllgf ghfavnqlqq lsdisaiied sissnekltf yeevqpgtin eiymketiyd 841 adidtgdivs fevpgavlpd tfpvyatikd fysylryrvk lkfskfdgss eeygvsneip 901 esfefwisay apyddlarmv skyahvkpey lkiialysng rfvlkstsll ndyllkdfnc 961 dqippfafev lsvplkeler lrpiklywlk nsyihyqcfe fevandytes qflekvqhki 1021 gftdeekeni llwtntnfqf qgllsdqntf kdvskhsllf grilpeeskl fkelnrlenv 1081 qtssledfmd denatdrpmd deqdlgmaie hsedmkgriv vvqqyfkdle nrhgisflfn 1141 lipdetfpkt kdrlhakfgl gqkefskikl sigysteegt vfrslqgfsd eeldkvilyd 1201 imsnldyiym dhpdrlrshs sydrpmiikn // LOCUS NP_014035 389 aa linear PLN 30-JUN-2025 DEFINITION putative family 17 glucosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014035 VERSION NP_014035.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182815.1 REFERENCE 1 (residues 1 to 389) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 389) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 389) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 389) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10206. Method: conceptual translation. FEATURES Location/Qualifiers source 1..389 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..389 /product="putative family 17 glucosidase" /calculated_mol_wt="40338" Region 137..>389 /region_name="Scw11" /note="Exo-beta-1,3-glucanase, GH17 family [Carbohydrate transport and metabolism]; COG5309" /db_xref="CDD:444107" CDS 1..389 /gene="SCW10" /locus_tag="YMR305C" /coded_by="NM_001182815.1:1..1170" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:19129178]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:9748433|PMID:15781460]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000747 conjugation with cellular fusion [PMID:9748433]" /note="Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p; SWC10 has a paralog, SCW4, that arose from the whole genome duplication" /db_xref="GeneID:855352" /db_xref="SGD:S000004921" ORIGIN 1 mrfsnfltvs alltgalgap avrhkhekrd vvtatvhaqv tvvvsgnsge tivpvnenav 61 vattsstava sqattstlep ttsanvvtsq qqtstlqsse aastvgssts sspsssssts 121 ssasssasss isasgakgit yspynddgsc kstaqvasdl eqltgfdnir lygvdcsqve 181 nvlqaktssq klflgiyyvd kiqdavdtik savesygswd dittvsvgne lvnggsattt 241 qvgeyvstak saltsagytg svvsvdtfia vinnpdlcny sdymavnaha yfdentaaqd 301 agpwvleqie rvytacggkk dvvitetgwp skgdtygeav pskanqeaai ssiksscgss 361 aylftafndl wkddgqygve kywgilssd // LOCUS NP_014036 1785 aa linear PLN 30-JUN-2025 DEFINITION putative 1,3-beta-D-glucan synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014036 VERSION NP_014036.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182817.1 REFERENCE 1 (residues 1 to 1785) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1785) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1785) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1785) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10207. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1785 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1785 /product="putative 1,3-beta-D-glucan synthase" /EC_number="2.4.1.34" /calculated_mol_wt="207353" Region 182..290 /region_name="FKS1_dom1" /note="1,3-beta-glucan synthase subunit FKS1, domain-1; pfam14288" /db_xref="CDD:464126" Region 694..1542 /region_name="Glucan_synthase" /note="1,3-beta-glucan synthase component; pfam02364" /db_xref="CDD:426739" CDS 1..1785 /gene="FKS3" /locus_tag="YMR306W" /coded_by="NM_001182817.1:1..5358" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:17158736]" /note="Protein involved in spore wall assembly; has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:855353" /db_xref="SGD:S000004923" ORIGIN 1 mdfmspkfsl tdveypawcq ddevpitmqe ireifvelmd kfgfqkssme nmyqhlmgql 61 dsrasrtgaq nalvslhvsy iggehanyrk wyfaaqldld eeigfqnmrl hgkarqrnvk 121 makkrgvsik eqikqwneke qefinnhpki tltqeqledq tnlksadykw klkmkkltpe 181 nmirqlalyl lcwgeanqvr fapeclcfif kcaldydist sssektvksp eysylndvit 241 plyeflrgqv ykkdakgnwk rrekdhknii gyddinqlfw ypegferiil nngerlvdkp 301 leerylyfkd vawskvfykt yretrswkhc ftnfnrfwii hfapfwfftt fnsptlytkn 361 yiqllnnqpt pqvrlsviaf ggtiaclvqi latvfewgfv prewpgaqhl ssrmigllfc 421 lainlgpsvy vlgffewdvh sksayivsiv qliiaflttf ffavrplggl frpylnkdkk 481 hrryissqtf tasfpkltgr skwfsyglwv fvylakyies yffltlslrd pirvlsimdl 541 srcqgeyllg pilckwqaki tlvlmllsdl glffldtylw yiicncifsi vlsfslgtsi 601 ltpwknvysr lpkriyskil atsemdvkfk akilisqvwn aivismyreh llsiehlqrl 661 lfqqvdslmg dtrtlksptf fvaqddstfk smeffpsnse akrrisffaq slatpisepv 721 pvdcmptftv lvphysekil lglkeiiree spkskitvle ylkhlhptew ecfvkdtkll 781 smeksflkea esshdedrle ipdalydprs splsdhtesr klpteddlik ekindlpfsy 841 fgfnssepsy tlrtriwasl rtqtlyrtls gfmnyskaik llyrienpsl vslyrgnnea 901 lendlenmas rkfrmvvamq ryakfnkdev eatelllray pnmfisylle eleqnesekt 961 yyscltngya efdeesglrk pifkirlsgn pilgdgksdn qnhsiifyrg eyiqvidanq 1021 dnyleeclki rsvlsefeel elnptipyip gieyeeeppp iaivgsreyi fsenigvlgd 1081 iaagkeqtfg tlfartlaei ggklhyghpd flngifmttr gglskaqrgl hlnediyagm 1141 naicrggkik hsdyyqcgkg rdlgfgsiln fttkigagmg eqllsreyyy lgtqlpmdrf 1201 lsffyahpgf hlnnlfisfs vqlffvllln lgalnheiia cfydkdapit nletpvgcyn 1261 iqpalhwvsi fvlsifivff iafaplliqe vlekgiwraa srflhhllsm aplfevfvcq 1321 vysnsllmdl tfggakyist grgfaitrld fftlysrfvn isiysgfqvf fmllfaiism 1381 wqpallwfwi tvismcfapf ifnphqfafm dffidyktfi hwlfsgntky qkeswanfvk 1441 ssrsrftgyk sktvddised sghdskkarf wnvffaelfl pfcvflfnft afsfinaqtg 1501 vsdstptsav frlllvtflp iflnsivlfl lfwvslfvvp glsycckdag aviafiahtf 1561 svlvylldfe lmwflqgwnf trtlillitc inmhlilfkv fttifltrey knnkahlaww 1621 ngkwyntgmg wsiilqpire yfvkimessy faadfflghf llfiqtpiil lpfidywhtm 1681 vlfwmnprsi iahkriltrk qralrsrivs kyfslyfvml gvllfmliap ffagdfvssp 1741 qellegtlfe gifqpnnqnn ndtgpnapst iltttptlpt frtva // LOCUS NP_014038 559 aa linear PLN 30-JUN-2025 DEFINITION 1,3-beta-glucanosyltransferase GAS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014038 VERSION NP_014038.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182818.1 REFERENCE 1 (residues 1 to 559) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 559) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 559) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 559) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 559) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10208. Method: conceptual translation. FEATURES Location/Qualifiers source 1..559 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..559 /product="1,3-beta-glucanosyltransferase GAS1" /calculated_mol_wt="59451" Region 17..330 /region_name="Glyco_hydro_72" /note="Glucanosyltransferase; pfam03198" /db_xref="CDD:397351" Region 390..452 /region_name="X8" /note="X8 domain; pfam07983" /db_xref="CDD:400371" CDS 1..559 /gene="GAS1" /locus_tag="YMR307W" /gene_synonym="CWH52; GGP1" /coded_by="NM_001182818.1:1..1680" /experiment="EXISTENCE:direct assay:GO:0000936 primary cell septum [PMID:19793924]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:19793924]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:1824714|PMID:19793924|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15781460|PMID:19793924]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:18462190]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:19541632]" /experiment="EXISTENCE:direct assay:GO:0042124 1,3-beta-glucanosyltransferase activity [PMID:17397106|PMID:15355340|PMID:10809732]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:10716729]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:16986442]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:15645503]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:9515908]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:19541632]" /experiment="EXISTENCE:mutant phenotype:GO:1905897 regulation of response to endoplasmic reticulum stress [PMID:31275960]" /experiment="EXISTENCE:physical interaction:GO:0031507 heterochromatin formation [PMID:19541632]" /note="Beta-1,3-glucanosyltransferase required for cell wall assembly; also has role in transcriptional silencing; localizes to cell surface via glycosylphosphatidylinositol (GPI) anchor, also found at nuclear periphery; genetic interactions with histone H3 lysine acetyltransferases GCN5 and SAS3 indicate functions for Gas1p in DNA damage response and cell cycle regulation; protein demonstrates amyloid properties in vivo" /db_xref="GeneID:855355" /db_xref="SGD:S000004924" ORIGIN 1 mlfkslskla taaaffagva taddvpaiev vgnkffysnn gsqfyirgva yqadtanets 61 gstvndplan yescsrdipy lkklntnvir vyainttldh secmkalnda diyviadlaa 121 patsinrddp twtvdlfnsy ktvvdtfany tnvlgffagn evtnnytntd asafvkaair 181 dvrqyisdkn yrkipvgyss nddedtrvkm tdyfacgddd vkadfyginm yewcgksdfk 241 tsgyadrtae fknlsipvff seygcnevtp rlftevealy gsnmtdvwsg givymyfeet 301 nkyglvsidg ndvktlddfn nysseinkis ptsantksys attsdvacpa tgkywsaate 361 lpptpngglc scmnaanscv vsddvdsddy etlfnwicne vdcsgisang tagkygaysf 421 ctpkeqlsfv mnlyyeksgg sksdcsfsgs atlqtattqa scssalkeig smgtnsasgs 481 vdlgsgtess tassnasgss sksnsgssgs ssssssssas ssssskknaa tnvkanlaqv 541 vftsiislsi aagvgfalv // LOCUS NP_014039 1089 aa linear PLN 30-JUN-2025 DEFINITION importin PSE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014039 VERSION NP_014039.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182819.1 REFERENCE 1 (residues 1 to 1089) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1089) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1089) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1089) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1089) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1089) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1089) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10209. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1089 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1089 /product="importin PSE1" /calculated_mol_wt="120900" Region 106..128 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(120..121,124,127..128,157..158,161,164..165,168, 195..196,199,202..203,206,240..241,244,247..248,283..284, 287,290..291) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 140..168 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 177..207 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 222..248 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 261..292 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 274..365 /region_name="Importin_rep_4" /note="Importin repeat; pfam18808" /db_xref="CDD:408579" Site order(350,353..354,385..386,389,392..393,396,426..427,430, 433..434,437,469..470,473,476..477,511..512,515,518..519) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 368..396 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 381..435 /region_name="HEAT_EZ" /note="HEAT-like repeat; pfam13513" /db_xref="CDD:463906" Region <403..475 /region_name="HEAT_2" /note="HEAT repeats; pfam13646" /db_xref="CDD:433376" Region 408..438 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 450..477 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 491..520 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 766..868 /region_name="Importin_rep_6" /note="Importin repeat 6; pfam18829" /db_xref="CDD:465881" Region 1001..1054 /region_name="Importin_rep_5" /note="Importin repeat; pfam18816" /db_xref="CDD:465877" CDS 1..1089 /gene="PSE1" /locus_tag="YMR308C" /gene_synonym="KAP121" /coded_by="NM_001182819.1:1..3270" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9238021]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9238021]" /experiment="EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:11694505]" /experiment="EXISTENCE:genetic interaction:GO:0006406 mRNA export from nucleus [PMID:9238021]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:16651379]" /experiment="EXISTENCE:mutant phenotype:GO:0007088 regulation of mitotic nuclear division [PMID:14697200]" /experiment="EXISTENCE:mutant phenotype:GO:0060188 regulation of protein desumoylation [PMID:17403926]" /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:11274141]" /experiment="EXISTENCE:physical interaction:GO:0060188 regulation of protein desumoylation [PMID:17403926]" /experiment="EXISTENCE:physical interaction:GO:0061608 nuclear import signal receptor activity [PMID:11274141]" /note="Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p; required for stability of the Dam1p-Duo1p complex" /db_xref="GeneID:855356" /db_xref="SGD:S000004925" ORIGIN 1 msalpeevnr tllqivqafa spdnqirsva ekalseewit ennieylltf laeqaafsqd 61 ttvaalsavl frklalkapp ssklmimskn ithirkevla qirssllkgf lseradsirh 121 klsdaiaecv qddlpawpel lqalieslks gnpnfressf rilttvpyli tavdinsilp 181 ifqsgftdas dnvkiaavta fvgyfkqlpk sewsklgill psllnslprf lddgkddala 241 svfeslielv elapklfkdm fdqiiqftdm viknkdlepp arttalellt vfsenapqmc 301 ksnqnygqtl vmvtlimmte vsiddddaae wiesddtdde eevtydharq aldrvalklg 361 geylaaplfq ylqqmitste wrerfaamma lssaaegcad vligeipkil dmviplindp 421 hprvqygccn vlgqistdfs pfiqrtahdr ilpalisklt sectsrvqth aaaalvnfse 481 faskdilepy ldslltnllv llqsnklyvq eqalttiafi aeaaknkfik yydtlmplll 541 nvlkvnnkdn svlkgkcmec atligfavgk ekfhehsqel isilvalqns dideddalrs 601 yleqswsric rilgddfvpl lpivipplli takatqdvgl ieeeeaanfq qypdwdvvqv 661 qgkhiaihts vlddkvsame llqsyatllr gqfavyvkev meeialpsld fylhdgvraa 721 gatlipills cllaatgtqn eelvllwhka sskligglms epmpeitqvy hnslvngikv 781 mgdnclsedq laaftkgvsa nltdtyermq drhgdgdeyn enideeedft dedlldeink 841 siaavlkttn ghylknleni wpmintflld nepilvifal vvigdliqyg geqtasmkna 901 fipkvtecli spdarirqaa syiigvcaqy apstyadvci ptldtlvqiv dfpgskleen 961 rsstenasaa iakilyayns nipnvdtyta nwfktlptit dkeaasfnyq flsqlienns 1021 pivcaqsnis avvdsviqal nersltereg qtvissvkkl lgflpssdam aifnrypadi 1081 mekvhkwfa // LOCUS NP_014040 812 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF3 core subunit c [Saccharomyces cerevisiae S288C]. ACCESSION NP_014040 VERSION NP_014040.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182820.1 REFERENCE 1 (residues 1 to 812) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 812) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 812) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 812) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 812) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 812) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 812) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10210. Method: conceptual translation. FEATURES Location/Qualifiers source 1..812 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..812 /product="translation initiation factor eIF3 core subunit c" /calculated_mol_wt="93074" Region 92..640 /region_name="eIF-3c_N" /note="Eukaryotic translation initiation factor 3 subunit 8 N-terminus; pfam05470" /db_xref="CDD:428482" Region 712..796 /region_name="PINT" /note="motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; smart00088" /db_xref="CDD:214509" CDS 1..812 /gene="NIP1" /locus_tag="YMR309C" /coded_by="NM_001182820.1:1..2439" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:1332047|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9671501|PMID:9660829]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:19470581|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:15145951]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:15838098|PMID:11018020]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:9722586]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:15145951]" /note="eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3); involved in the assembly of preinitiation complex and start codon selection; eIF3 is also involved in programmed stop codon readthrough" /db_xref="GeneID:855357" /db_xref="SGD:S000004926" ORIGIN 1 msrffssnye ydvassssee dllssseedl lsssssesel dqesddsffn eseseseadv 61 dsddsdakpy gpdwfkksef rkqgggsnkf lkssnydssd eesdeedgkk vvksakekll 121 demqdvynki sqaensddwl tisnefdlis rllvraqqqn wgtpnifikv vaqvedavnn 181 tqqadlknka varaynttkq rvkkvsrene dsmakfrndp esfdkeptad ldisangfti 241 sssqgndqav qedfftrlqt iidsrgkktv nqqslistle elltvaekpy efimayltli 301 psrfdasanl syqpidqwks sfndisklls ildqtidtyq vnefadpidf iedepkedsd 361 gvkrilgsif sfverlddef mksllnidph ssdylirlrd eqsiynlilr tqlyfeatlk 421 dehdleralt rpfvkrldhi yyksenliki metaawniip aqfkskftsk dqldsadyvd 481 nlidglstil skqnniavqk railyniyyt alnkdfqtak dmlltsqvqt ninqfdsslq 541 ilfnrvvvql glsafklcli eechqilndl lssshlreil gqqslhrisl nssnnasade 601 rarqclpyhq hinldlidvv fltcslliei prmtafysgi kvkripyspk sirrslehyd 661 klsfqgppet lrdyvlfaak smqkgnwrds vkylreiksw allpnmetvl nsltervqve 721 slktyffsfk rfyssfsvak laelfdlpen kvvevlqsvi aeleipakln dektifvvek 781 gdeitkleea mvklnkeyki akerlnppsn rr // LOCUS NP_014041 317 aa linear PLN 30-JUN-2025 DEFINITION putative methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014041 VERSION NP_014041.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182821.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10211. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..317 /product="putative methyltransferase" /calculated_mol_wt="35721" Region 19..313 /region_name="Methyltrn_RNA_3" /note="Putative RNA methyltransferase; pfam02598" /db_xref="CDD:460611" CDS 1..317 /gene="UPA2" /locus_tag="YMR310C" /coded_by="NM_001182821.1:1..954" /experiment="EXISTENCE:curator inference:GO:0032259 methylation [PMID:22650761|PMID:21858014]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /note="Putative SPOUT methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; not an essential gene; YMR310C has a paralog, YGR283C, that arose from the whole genome duplication" /db_xref="GeneID:855358" /db_xref="SGD:S000004927" ORIGIN 1 msstrkfkkv ekplsqtrhy slcipttlvs dcrnlsqith kvyqvakfas lfnvsevvil 61 ednsqvdatk kkistaklil allqyfvtpp ylrntvfnek frpyltaask lprlstlpft 121 ryqkqdhgry regltikmqk ptlarkkigk vfkqtkyini gkskalalqs qlvpinarvt 181 idtitrkivs pqeaygdftg ldsqygyytr iassftdlfm kgplkegytq svyvplttrd 241 tsipelsslp taetnphill vfstwdtlar afkldqdqfv dcqgpqeffd aqlpcpvsns 301 dvadaipmtl ttlstvf // LOCUS NP_014042 229 aa linear PLN 30-JUN-2025 DEFINITION PP1-complex regulatory subunit GLC8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014042 VERSION NP_014042.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182822.1 REFERENCE 1 (residues 1 to 229) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 229) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 229) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 229) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10212. Method: conceptual translation. FEATURES Location/Qualifiers source 1..229 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..229 /product="PP1-complex regulatory subunit GLC8" /calculated_mol_wt="26518" Region 91..201 /region_name="IPP-2" /note="Protein phosphatase inhibitor 2 (IPP-2); pfam04979" /db_xref="CDD:461504" CDS 1..229 /gene="GLC8" /locus_tag="YMR311C" /coded_by="NM_001182822.1:1..690" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:12127071]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:7565759]" /note="Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855359" /db_xref="SGD:S000004928" ORIGIN 1 mggilknpla lspeqlaqqd petleefrrq vyentqknak ltshkrnipg ldntkeegei 61 igtsstflpk dtlslkheqd mlakmtpeer vqwnqrnlae neitkkqfqd ihidepktpy 121 qgavdphgey yrvdddeded nsdkkpcqva nddiddlslg epefeikenk qpdfetnden 181 dedspearhk kfeemrkkhy dvraifnkks realkdeded eddsttkep // LOCUS NP_014043 273 aa linear PLN 30-JUN-2025 DEFINITION Elongator subunit ELP6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014043 VERSION NP_014043.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182823.1 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10213. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..273 /product="Elongator subunit ELP6" /calculated_mol_wt="30443" Region 32..221 /region_name="Elp456" /note="Elongator subcomplex subunits Elp4, 5 and 6; cd19479" /db_xref="CDD:410887" Site order(33,35,38,41,43,82,105,107,167..169,172,175,186, 188..189,206..210,212..213,218,220) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:410887" CDS 1..273 /gene="ELP6" /locus_tag="YMR312W" /gene_synonym="HAP3; KTI4; TOT6" /coded_by="NM_001182823.1:1..822" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:22343726]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:22343726]" /experiment="EXISTENCE:direct assay:GO:0033588 elongator holoenzyme complex [PMID:11689709]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11689709]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:22343726]" /experiment="EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14551258]" /note="Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity" /db_xref="GeneID:855360" /db_xref="SGD:S000004929" ORIGIN 1 mgsvqrqdlv lfsdqsvlpa hffqdsnshn lffithqsct qplwminalv ethvlgspss 61 lnessssmlp sstrshavla sfiheqnyft nslnklkips nnynvldfls dfivnnihnk 121 prdkilsdvl akfsaaiqnn ptdtiviieq pelllslvsg ltcselnnkf itpllrqckv 181 liivsnsdif nideydasvh ssnlqnfyks sfiksminln lnplktgfak dvtgslhvcr 241 ggapiatsnt slhvveneyl ylnekestkl fyr // LOCUS NP_014044 642 aa linear PLN 30-JUN-2025 DEFINITION bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014044 VERSION NP_014044.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182824.1 REFERENCE 1 (residues 1 to 642) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 642) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 642) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 642) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10214. Method: conceptual translation. FEATURES Location/Qualifiers source 1..642 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..642 /product="bifunctional triglyceride lipase/lysophosphatidylethanolamine acyltransferase" /EC_number="3.1.1.3" /calculated_mol_wt="73482" Region 130..640 /region_name="Pat_TGL3_like" /note="Triacylglycerol lipase 3; cd07229" /db_xref="CDD:132867" Site order(209..210,212,237,406) /site_type="active" /db_xref="CDD:132867" Site 235..239 /site_type="other" /note="nucleophile elbow" /db_xref="CDD:132867" CDS 1..642 /gene="TGL3" /locus_tag="YMR313C" /coded_by="NM_001182824.1:1..1929" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:12682047]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24390141|PMID:16267052|PMID:10515935|PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0071618 lysophosphatidylethanolamine acyltransferase activity [PMID:20016004]" /experiment="EXISTENCE:genetic interaction:GO:0007114 cell budding [PMID:19150427]" /experiment="EXISTENCE:genetic interaction:GO:0019433 triglyceride catabolic process [PMID:16267052]" /experiment="EXISTENCE:mutant phenotype:GO:0004806 triacylglycerol lipase activity [PMID:12682047]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:10515935]" /experiment="EXISTENCE:mutant phenotype:GO:0007114 cell budding [PMID:19150427]" /experiment="EXISTENCE:mutant phenotype:GO:0019433 triglyceride catabolic process [PMID:16267052]" /note="Bifunctional triacylglycerol lipase and LPE acyltransferase; major lipid particle-localized triacylglycerol (TAG) lipase; catalyzes acylation of lysophosphatidylethanolamine (LPE), a function which is essential for sporulation; protein level and stability of Tgl3p are markedly reduced in the absence of lipid droplets; required with Tgl4p for timely bud formation" /db_xref="GeneID:855361" /db_xref="SGD:S000004930" ORIGIN 1 mketaqeykv saviptllkn wilrvvyatl dhippfvwei lhvitdiyff wvqklinyvr 61 phsrviyyna ikkldecdty qmwcqqasvv deitganlwr rnffsrrydf nsvieqysil 121 enmlreekyd vvkekfsttg pcmlrnfagi gdkklftksl mgtkllieqy ltrilegldi 181 lnnqtltpts ffqrcklslg ttalilqggs lfglfhlgvi rglllqdlmp niisgssmga 241 cvaslfgcls neqlkqlltd dnllniiknd vdllkscgyg nleqhlnlgt liqnlihhgy 301 sqdvylfirf vmkyivkekt feevyqitgk vfnivihptd kscpnllnyv ttpnvliksa 361 iecslgsgvi sedtsllckn leneiepfln inknkqvkfl tpenannpsi tespytrlte 421 lfnvnnfivs larpylaplv vndlkheikt skyyyykhyp nmppinantv rktqrsssqs 481 pikagtvedl epeplmspvp pssavndsae yiipelgipq lnftemepla fkfkyhlerk 541 lkniatmefr hrmevldnlg llcslikrli idektprsat eiavvprmks lsltriiegq 601 lnnipywiks gerstwpala liktrcavef klddiirarr sr // LOCUS NP_014045 234 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit alpha 6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014045 VERSION NP_014045.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182825.1 REFERENCE 1 (residues 1 to 234) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 234) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 234) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 234) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10215. Method: conceptual translation. FEATURES Location/Qualifiers source 1..234 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..234 /product="proteasome core particle subunit alpha 6" /calculated_mol_wt="25473" Region 6..217 /region_name="Ntn_hydrolase" /note="The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; cl00467" /db_xref="CDD:469781" Site order(33,49,51,62) /site_type="active" /db_xref="CDD:238884" CDS 1..234 /gene="PRE5" /locus_tag="YMR314W" /coded_by="NM_001182825.1:1..705" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019773 proteasome core complex, alpha-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /note="Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855362" /db_xref="SGD:S000004931" ORIGIN 1 mfrnnydgdt vtfsptgrlf qveyaleaik qgsvtvglrs nthavlvalk rnadelssyq 61 kkiikcdehm glslaglapd arvlsnylrq qcnysslvfn rklaveragh llcdkaqknt 121 qsyggrpygv glliigydks gahllefqps gnvtelygta igarsqgakt ylertldtfi 181 kidgnpdeli kagveaisqs lrdesltvdn lsiaivgkdt pftiydgeav akyi // LOCUS NP_014046 349 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR315W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014046 VERSION NP_014046.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182826.1 REFERENCE 1 (residues 1 to 349) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 349) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 349) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 349) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10216. Method: conceptual translation. FEATURES Location/Qualifiers source 1..349 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..349 /product="uncharacterized protein" /calculated_mol_wt="38085" Region 1..270 /region_name="MviM" /note="Predicted dehydrogenase [General function prediction only]; COG0673" /db_xref="CDD:440437" CDS 1..349 /locus_tag="YMR315W" /coded_by="NM_001182826.1:1..1050" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016651 oxidoreductase activity, acting on NAD(P)H [PMID:19712762]" /experiment="EXISTENCE:genetic interaction:GO:0006740 NADPH regeneration [PMID:19712762]" /note="Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains an Stb5p binding site and Stb5p binding is enriched at the promoter; negative regulator of nonselective autophagy; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855363" /db_xref="SGD:S000004932" ORIGIN 1 msplnvgivg tgifardrhl psyqefpdkf kviaafnrhk akaldfakva dipenkvydn 61 ldeilndphv dyidallpaq fnadivekav kagkpvilek piaanldqak eivkiaestp 121 lpvgvaenwl ylpcikiake qiekigpvva fthnstgpfv tqnkyltttw rqkpehiggf 181 lsdggvhqla lvisllgefg svsaltrqvr ersgaddivf atvqlknkev igsftygsaf 241 gateksvflk vygkngtvtv dlsdkkdpvv kvklggsaed ngdeqifkvd ndesfgvnae 301 flnfheavsk kdkslylgtp rtafhhlacv daflkssakn gdyvkieqp // LOCUS NP_878150 35 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR315W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878150 VERSION NP_878150.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184618.1 REFERENCE 1 (residues 1 to 35) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 35) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 35) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 35) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 35) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 35) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 35) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10217. Method: conceptual translation. FEATURES Location/Qualifiers source 1..35 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..35 /product="uncharacterized protein" /calculated_mol_wt="3923" CDS 1..35 /locus_tag="YMR315W-A" /coded_by="NM_001184618.1:1..108" /note="hypothetical protein" /db_xref="GeneID:1466508" /db_xref="SGD:S000028697" ORIGIN 1 mterkllqll rrpfislslf talracplrp kslia // LOCUS NP_014047 336 aa linear PLN 30-JUN-2025 DEFINITION Dia1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014047 VERSION NP_014047.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182829.1 REFERENCE 1 (residues 1 to 336) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 336) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 336) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 336) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10218. Method: conceptual translation. FEATURES Location/Qualifiers source 1..336 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..336 /product="Dia1p" /calculated_mol_wt="38629" CDS 1..336 /gene="DIA1" /locus_tag="YMR316W" /coded_by="NM_001182829.1:1..1011" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:11063681]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:11063681]" /note="hypothetical protein; involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" /db_xref="GeneID:855364" /db_xref="SGD:S000004935" ORIGIN 1 mgsisryllk kaadglkdeq rlkiemsdsk svpecfhfnr errmpiaein gedgffmfps 61 qqslenfent kkysnelspd aigiplfqii nctlpfgkrg hsntvvgnvp yykifkfilr 121 tadepppytv akivcsnngl ilykvplydi yknvsqanvt ysfvgttste pnllamahre 181 ghrdldtkvn nlnlrwhvty spvvtndhyk lilladyevn rldedviraa knkmsidqkd 241 qkvqrfvaah ytrefetslf rwvaqeghli lgeystdqgs fglnnipplt eelgcqslli 301 hyieymkrqr kkiakearrq nkrnvanttn mnmnlm // LOCUS NP_001257686 103 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR316C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257686 VERSION NP_001257686.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270757.1 REFERENCE 1 (residues 1 to 103) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 103) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 103) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 103) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35127. Method: conceptual translation. FEATURES Location/Qualifiers source 1..103 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..103 /product="uncharacterized protein" /calculated_mol_wt="12280" CDS 1..103 /locus_tag="YMR316C-A" /coded_by="NM_001270757.1:1..312" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; mRNA identified as translated by ribosome profiling data; overlaps the verified gene DIA1/YMR316W" /db_xref="GeneID:855365" /db_xref="SGD:S000004933" ORIGIN 1 mtgfkvssff yilalsrffn agreracdkl kitvthlywf iirklllhev hvhvsrvcnv 61 sfilspclfr nfftlslhvl yvmyeqaltp effrqwwdii qsk // LOCUS NP_014050 1140 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR317W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014050 VERSION NP_014050.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182830.2 REFERENCE 1 (residues 1 to 1140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1140) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 1140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10219. On Apr 26, 2011 this sequence version replaced NP_014050.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..1140 /product="uncharacterized protein" /calculated_mol_wt="113050" Region <922..>1128 /region_name="ser_rich_anae_1" /note="serine-rich protein; NF033849" /db_xref="CDD:468206" CDS 1..1140 /locus_tag="YMR317W" /coded_by="NM_001182830.2:1..3423" /note="hypothetical protein; YMR317W is not an essential gene" /db_xref="GeneID:855366" /db_xref="SGD:S000004936" ORIGIN 1 mgssgskstt atttshsstt ttssttsttt ptttsttstt stkvttspei ivsssstlvs 61 svvpeftsss slssdtiasi lsseslvsif sslsytssdi sstsvndves stsgpsnsys 121 alsstnaqls ssttetdsis ssaiqtsspq tsssngggss seplgkssvl ettasssdtt 181 avtsstfttl tdvssspkis ssgsavtsvg ttsdaskevf ssstsdvssl lsstsspass 241 tisetlpfss tilsitsspv sseapsatss visseaswat sssvsseapl atssvvssea 301 psstssvvss eapsstsssv sseissttss svsseaplat ssvvsseaps stsssvssei 361 ssttsssvss eaplatssvv sseapsstss svsseapsst sssvsseaps stsssvssei 421 sstkssvmss evssatsslv sseapsaiss lassrlfssk ntsvtstlva teassvtssl 481 rpssetlasn siiesslstg ynstvsttts aasstlgskv sssnsrmats ktsstssdls 541 kssvifgnss tvttspsasi sltasplpsv wsditsseas sissnlasss apsdnnstia 601 saslivtktk nsvvssivss itssettnes nlatsstsll snkatarsls tsnatsasnv 661 ptgtfssmss htsvitpgfs tssaslains tvvssslagy sfstpesspt tstlvtseap 721 stvssmttsa pfinnstsar pspstasfit estssissvp lasgdvtssl aahnlttfsa 781 pstssaqlvs ksttsssilv tpridrsgns stasriatsl pnkttfvssl sstsaharni 841 fnstvlatak qietltstvn csnptpnyni tktvivsret taigtvtscs ggctknrkst 901 tlititdida stvttcpeke vtsttsgdea ehttstkisn fetstfsesf kdmktsqetk 961 kakpgsetvr ssssfvekts pttkaspsts pseskaagnt svatnaspst spsesqgtgs 1021 tsvegaksks tknsegvstt kakntstvak sstespigrg ettletiivs sqkslltsql 1081 ssstekvnrs ttkptaaihg tsssakqstt ytvstakent gaslninmka fvigaialva // LOCUS NP_014051 360 aa linear PLN 30-JUN-2025 DEFINITION NADP-dependent alcohol dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014051 VERSION NP_014051.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182831.3 REFERENCE 1 (residues 1 to 360) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 360) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 360) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 360) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10220. On Jul 30, 2012 this sequence version replaced NP_014051.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..360 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..360 /product="NADP-dependent alcohol dehydrogenase" /EC_number="1.1.1.2" /calculated_mol_wt="39487" Region 8..352 /region_name="CAD1" /note="Cinnamyl alcohol dehydrogenases (CAD); cd05283" /db_xref="CDD:176186" Site order(46,48,68,95,163,301) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:176186" Site order(46,68,163) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176186" Site order(100,103,106,114) /site_type="other" /note="structural Zn binding site [ion binding]" /db_xref="CDD:176186" Site order(113,170,174,269,274..276,278,289,291,293..300) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:176186" CDS 1..360 /gene="ADH6" /locus_tag="YMR318C" /gene_synonym="ADHVI" /coded_by="NM_001182831.3:1..1083" /experiment="EXISTENCE:direct assay:GO:0006066 alcohol metabolic process [PMID:11742541]" /experiment="EXISTENCE:direct assay:GO:0006081 aldehyde metabolic process [PMID:11742541]" /experiment="EXISTENCE:direct assay:GO:0008106 alcohol dehydrogenase (NADP+) activity [PMID:11742541]" /experiment="EXISTENCE:mutant phenotype:GO:0033833 hydroxymethylfurfural reductase (NADH) activity [PMID:16652391]" /experiment="EXISTENCE:mutant phenotype:GO:0033845 hydroxymethylfurfural reductase (NADPH) activity [PMID:16652391]" /experiment="EXISTENCE:mutant phenotype:GO:0033859 furaldehyde metabolic process [PMID:16652391]" /note="NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855368" /db_xref="SGD:S000004937" ORIGIN 1 msypekfegi aiqshedwkn pkktkydpkp fydhdidiki eacgvcgsdi hcaaghwgnm 61 kmplvvghei vgkvvklgpk snsglkvgqr vgvgaqvfsc lecdrckndn epyctkfvtt 121 ysqpyedgyv sqggyanyvr vhehfvvpip enipshlaap llcggltvys plvrngcgpg 181 kkvgivglgg igsmgtlisk amgaetyvis rssrkredam kmgadhyiat leegdwgeky 241 fdtfdlivvc assltdidfn impkamkvgg rivsisipeq hemlslkpyg lkavsisysa 301 lgsikelnql lklvsekdik iwvetlpvge agvheaferm ekgdvryrft lvgydkefsd // LOCUS NP_014052 552 aa linear PLN 30-JUN-2025 DEFINITION Fet4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014052 VERSION NP_014052.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182832.1 REFERENCE 1 (residues 1 to 552) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 552) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 552) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 552) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10221. Method: conceptual translation. FEATURES Location/Qualifiers source 1..552 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..552 /product="Fet4p" /calculated_mol_wt="62661" Region 206..325 /region_name="Iron_permease" /note="Low affinity iron permease; cl12096" /db_xref="CDD:472274" Region 350..>399 /region_name="Iron_permease" /note="Low affinity iron permease; cl12096" /db_xref="CDD:472274" Region 454..>519 /region_name="Iron_permease" /note="Low affinity iron permease; cl12096" /db_xref="CDD:472274" CDS 1..552 /gene="FET4" /locus_tag="YMR319C" /coded_by="NM_001182832.1:1..1659" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005375 copper ion transmembrane transporter activity [PMID:11023834]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9115232|PMID:12469340]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006829 zinc ion transport [PMID:12095998]" /experiment="EXISTENCE:mutant phenotype:GO:0005375 copper ion transmembrane transporter activity [PMID:11023834]" /experiment="EXISTENCE:mutant phenotype:GO:0005381 iron ion transmembrane transporter activity [PMID:7929320]" /experiment="EXISTENCE:mutant phenotype:GO:0006825 copper ion transport [PMID:11523804]" /experiment="EXISTENCE:mutant phenotype:GO:0006829 zinc ion transport [PMID:12095998]" /experiment="EXISTENCE:mutant phenotype:GO:0015677 copper ion import [PMID:11023834]" /experiment="EXISTENCE:mutant phenotype:GO:0034755 iron ion transmembrane transport [PMID:7929320]" /note="Low-affinity Fe(II) transporter of the plasma membrane" /db_xref="GeneID:855369" /db_xref="SGD:S000004938" ORIGIN 1 mgkiaeflgn pgarpdvhhr aptvdckqye efgdsndykn ddvvrvvshs destddelcn 61 vnltetgaif tskgftglsk gftdktldfl vrvagsqavf fivwiiliiw vvigivynap 121 fnwqvvmqdg qsiqsyvwdt llmrqqlmst heqilicgrl ksrlasfkny ltrstpeeek 181 adctveanev ssvenhidps aingelpven wydrlsnvas rymgsiaamv ifwigifvwi 241 gcgaipkdag ntppytgett gsnprlkkfs dawqmyinta vavsllictt flqnirarhd 301 yftgrflvdi fdmdekidyr irkhfndfet phpvvtiesk krstgrkmid wyadiigtgi 361 gvligvavfa twigigspmk wddnwwliig tytgligfld gfvlrevyfr ivqheeknys 421 dvakedlelf qelgiecpee fsgkapeint igyrtsqyin ricstpwsvl vsviiiigli 481 ciasglrwst tgqliantpt miieeffllv llqahnwadr qrrvevtaly arrrillsyv 541 ekrfpevmml ek // LOCUS NP_014054 105 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR321C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014054 VERSION NP_014054.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182834.3 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10222. On Jul 30, 2012 this sequence version replaced NP_014054.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..105 /product="uncharacterized protein" /calculated_mol_wt="11491" Region <15..103 /region_name="PRK07534" /note="betaine--homocysteine S-methyltransferase; cl22882" /db_xref="CDD:473986" CDS 1..105 /locus_tag="YMR321C" /coded_by="NM_001182834.3:1..318" /note="hypothetical protein; proposed to be a palmitoylated membrane protein; YMR321C has a paralog, SAM4, that arose from a single-locus duplication" /db_xref="GeneID:855371" /db_xref="SGD:S000004940" ORIGIN 1 mmdlgdkinp nlsflgincv sfnqspdile slhqalpnma llaypnsgev ydtekkiwlp 61 nsdklnswdt vvkqyissga riiggccrts pkdiqeisaa vkkyt // LOCUS NP_014055 237 aa linear PLN 30-JUN-2025 DEFINITION glutathione-independent methylglyoxalase family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_014055 VERSION NP_014055.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182835.1 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10223. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..237 /product="glutathione-independent methylglyoxalase family protein" /EC_number="4.2.1.130" /calculated_mol_wt="25909" Region 5..235 /region_name="GAT_1" /note="Type 1 glutamine amidotransferase (GATase1)-like domain; cl00020" /db_xref="CDD:469582" Site 138 /site_type="active" /note="conserved cys residue [active]" /db_xref="CDD:153241" CDS 1..237 /gene="SNO4" /locus_tag="YMR322C" /gene_synonym="HSP34" /coded_by="NM_001182835.1:1..714" /experiment="EXISTENCE:direct assay:GO:0019172 glyoxalase III activity [PMID:26370081]" /experiment="EXISTENCE:mutant phenotype:GO:0019172 glyoxalase III activity [PMID:26370081]" /experiment="EXISTENCE:mutant phenotype:GO:0031669 cellular response to nutrient levels [PMID:24706893]" /note="Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation" /db_xref="GeneID:855372" /db_xref="SGD:S000004941" ORIGIN 1 mtpkralisl tsyhgpfykd gaktgvfvve ilrsfdtfek hgfevdfvse tggfgwdehy 61 lpksfigged kmnfetknsa fnkalarikt anevnasdyk iffasaghga lfdypkaknl 121 qdiaskiyan ggviaaichg pllfdglidi kttrpliegk aitgfplege ialgvddilr 181 srklttverv anknrakyla pihpwddysi tdgklvtgvn anssysttir ainalys // LOCUS NP_014056 437 aa linear PLN 30-JUN-2025 DEFINITION phosphopyruvate hydratase ERR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014056 VERSION NP_014056.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182836.3 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10224. On Jul 30, 2012 this sequence version replaced NP_014056.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..437 /product="phosphopyruvate hydratase ERR3" /EC_number="4.2.1.11" /calculated_mol_wt="47182" Region 1..428 /region_name="PTZ00081" /note="enolase; Provisional" /db_xref="CDD:240259" CDS 1..437 /gene="ERR3" /locus_tag="YMR323W" /coded_by="NM_001182836.3:1..1314" /experiment="EXISTENCE:direct assay:GO:0004634 phosphopyruvate hydratase activity [PMID:23359425]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:genetic interaction:GO:0004634 phosphopyruvate hydratase activity [PMID:23359425]" /note="Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose" /db_xref="GeneID:855373" /db_xref="SGD:S000004942" ORIGIN 1 msitkvhart vydsrgnptv eveittengl fraivpsgas tgiheavelr dgnksewmgk 61 gvtkavsnvn siigpaliks dlcvtnqkgi delmisldgt snksrlgana ilgvslcvar 121 aaaaqkgitl ykyiaelada rqdpfvipvp ffnvlnggah aggslamqef kiapvgaqsf 181 aeamrmgsev yhhlkilake qygpsagnvg deggvapdid taedaldmiv kainicgyeg 241 rvkvgidsap svfykdgkyd lnfkepnsdp shwlspaqla eyyhsllkky piisledpya 301 eddwsswsaf lktvnvqiia ddltctnktr iaraieekca ntlllklnqi gtltesieaa 361 nqafdagwgv mishrsgete dpfiadlvvg lrcgqiksga lsrserlaky nellrieeel 421 gddciyaghr fhdgnkl // LOCUS NP_014058 124 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU19 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014058 VERSION NP_014058.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182838.1 REFERENCE 1 (residues 1 to 124) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 124) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 124) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 124) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10225. Method: conceptual translation. FEATURES Location/Qualifiers source 1..124 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..124 /product="seripauperin PAU19" /calculated_mol_wt="13042" Region 26..118 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..124 /gene="PAU19" /locus_tag="YMR325W" /coded_by="NM_001182838.1:1..375" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions" /db_xref="GeneID:855375" /db_xref="SGD:S000004944" ORIGIN 1 mvkltsiaag vaaiaagvaa apatttlsps dervnlvelg vyvsdirahl aqyylfqaah 61 ptetypveia eavfnygdft tmltgipaeq vtrvitgvpw ystrlrpais salskdgiyt 121 aipk // LOCUS NP_001335810 101 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YMR320W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335810 VERSION NP_001335810.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348871.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Bowman,S., Churcher,C., Badcock,K., Brown,D., Chillingworth,T., Connor,R., Dedman,K., Devlin,K., Gentles,S., Hamlin,N., Hunt,S., Jagels,K., Lye,G., Moule,S., Odell,C., Pearson,D., Rajandream,M., Rice,P., Skelton,J., Walsh,S., Whitehead,S. and Barrell,B. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII JOURNAL Nature 387 (6632 SUPPL), 90-93 (1997) PUBMED 9169872 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80330. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIII" Protein 1..101 /product="uncharacterized protein" /calculated_mol_wt="11686" CDS 1..101 /locus_tag="YMR320W" /coded_by="NM_001348871.1:1..306" /note="hypothetical protein; conserved among S. cerevisiae strains; YMR320W is not an essential gene" /db_xref="GeneID:855370" /db_xref="SGD:S000004939" ORIGIN 1 mrrfgkpciv sheisarphi lqpcnykmvl sckvkkpiel lhlqelilyt fmkiclhvnl 61 iqqninklsy isrkyprapa fiscdnrate ptkkgflvcr m // LOCUS NP_014060 1859 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase protein 1 copy 6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014060 VERSION NP_014060.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183177.1 REFERENCE 1 (residues 1 to 1859) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1859) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1859) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1859) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10226. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1859 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1859 /product="Y' element ATP-dependent helicase protein 1 copy 6" /EC_number="3.6.4.12" /calculated_mol_wt="210969" Region 38..152 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 854..1026 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" Region 1101..1196 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1859 /gene="YRF1-6" /locus_tag="YNL339C" /gene_synonym="YRF1" /coded_by="NM_001183177.1:1..5580" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9837911]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]" /note="Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" /db_xref="GeneID:855377" /db_xref="SGD:S000005283" ORIGIN 1 meieneqict ciaqilhlln sliitflddd ktetgqsfvy idgflvkkhn nqhtivnfet 61 yknkmkvsdr rkfekanfde fesalnnknd lvhcpsitlf esiptevrsf yedeksglik 121 vvkfrtgamd rkrsfekivv svmvgknvqk fltfvedepd fqggpipsky lipkkinlmv 181 ytlfqvhtlk fnrkdydtls lfylnrgyyn elsfrvlerc yeiasarpnd sstmrtftdf 241 vsgtpivrgl qkstirkygy nlapymflll hvdelsifsa yqaslpgekk vdterlkrdl 301 cprkpteiky fsqicndmmn kkdrlgdilh iilracalnf gagprggagd eedrsitnee 361 piipsvdehg lkvcklrspn tprrlrktld avkallvssc actardldif ddnngvamwk 421 wikilyheva qetalkdsyr itlvpssdgv svcgklfnre yvrgfyfack aqfdnlweel 481 ndcfymptvv diaslilrnr evlfrepkrg ideylendsf lqmipvkyre ivlpklrrdt 541 nkmtaalknk vtvaideltv plmwmihfav gypyrypelq llafagpqrn vyvddttrri 601 qlytdynkng sseprlktld gltsdyvfyf vtvlrqmqic algnsydafn hdpwmdvvgf 661 edpdqvtnrd isrivlysym flntakgclv eyatfrqymr elpknapqkl nfremrqgli 721 algrhcvgsr fetdlyesat selmanhsvq tgrniygvds fsltsvsgtt atllqerase 781 rwiqwlgles dyhcsfsstr naedvvagea assdhhqkis rvtrkrprep kstndilvag 841 qklfgssfef rdlhqlrlch eiymadtpsv avqappgygk telfhlplia laskgdvkyv 901 sflfvpytvl lancmirlsr cgclnvapvr nfieegcdgv tdlyvgiydd lastnftdri 961 aawenivect frtnnvklgy livdefhnfe tevyrqsqfg gitnldfdaf ekaiflsgta 1021 peavadaalq rigltglakk smdinelkrs edlsrglssy ptrmfnlike ksevplghvh 1081 kiwkkvesqp eealklllal feiepeskai vvasttneve elacswrkyf rvvwihgklg 1141 aaekvsrtke fvtdgsmrvl igtklvtegi dikqlmmvim ldnrlniiel iqgvgrlrdg 1201 glcyllsrkn swaarnrkge lppikegcit eqvrefygle skkgkkgqhv gccgsrtdls 1261 adtvelierm drlaekqata smsivalpss fqesnssdrc rkycssdeds dtcihgsana 1321 stnattnsst natttastnv rtsatttasi nvrtsattte stnsstnatt tastnvrtsa 1381 tttasinvrt satttestns ntsatttest dsntsattte stdsntsatt tastnsstna 1441 tttastnsst natttestna sakedankdg naednrfhpv tdinkesykr kgsqmvller 1501 kklkaqfpnt senmnvlqfl gfrsdeikhl flygidvyfc pegvftqygl ckgcqkmfel 1561 cvcwagqkvs yrrmaweala vermlrndee ykeylediep yhgdpvgylk ffsvkrgeiy 1621 sqiqrnyawy laitrrreti svldstrgkq gsqvfrmsgr qikelyykvw snlresktev 1681 lqyflnwdek kcreeweakd dtvfvealek vgvfqrlrsm tsaglqgpqy vklqfsrhhr 1741 qlrsryelsl gmhlrdqlal gvtpskvphw taflsmligl fcnktfrqkl eylleqisev 1801 wllphwldla nvevlaadnt rvplymlmva vhkeldsddv pdgrfdillc rdssrevge // LOCUS NP_014063 381 aa linear PLN 30-JUN-2025 DEFINITION Cos1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014063 VERSION NP_014063.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183174.1 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10227. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..381 /product="Cos1p" /calculated_mol_wt="45157" Region 73..167 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 267..353 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..381 /gene="COS1" /locus_tag="YNL336W" /coded_by="NM_001183174.1:1..1146" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:25942624]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /db_xref="GeneID:855380" /db_xref="SGD:S000005280" ORIGIN 1 mkenelknek svdvlsfkql esqkivlpqd lfrssftwfc yeiykslafr iwmllwlpls 61 vwwklsnnci yplivsllvl flgpifvlvi cglsrkrsls kqliqfckev tentpssdph 121 dwevvaanln sylyenkawn tkyfffnamv cqeafrttll epfslkkdea akvksfkdsv 181 pyieealgvy frevekqwkl fnsekswspv gledaklpke ayrfkltwfl krisnifmli 241 pflnflcciy vsrgmclllr tfylgwilfm lvqgfqnmrm ivlsvkmehk mqflstiine 301 qesgangwde iakkmnrylf ekkvwkneef ffdgidcewf fshffyrvls akksmralsl 361 nvelwpyike aqlscseesl a // LOCUS NP_014064 225 aa linear PLN 30-JUN-2025 DEFINITION cyanamide hydratase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014064 VERSION NP_014064.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183173.1 REFERENCE 1 (residues 1 to 225) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 225) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 225) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 225) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 225) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10228. Method: conceptual translation. FEATURES Location/Qualifiers source 1..225 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..225 /product="cyanamide hydratase" /EC_number="4.2.1.69" /calculated_mol_wt="25021" Region 2..224 /region_name="cyanamide_fam" /note="HD domain protein, cyanamide hydratase family; TIGR03401" /db_xref="CDD:188314" Site order(55,88..89,157) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238032" Site 89 /site_type="other" /note="Mg2+ binding site [ion binding]" /db_xref="CDD:238032" CDS 1..225 /gene="DDI2" /locus_tag="YNL335W" /gene_synonym="DDI3" /coded_by="NM_001183173.1:1..678" /experiment="EXISTENCE:direct assay:GO:0018820 cyanamide hydratase activity [PMID:25847245]" /experiment="EXISTENCE:mutant phenotype:GO:0018890 cyanamide metabolic process [PMID:25847245]" /note="Cyanamide hydratase that detoxifies cyanamide; member of the HD domain metalloprotein superfamily; expression is induced over 100-fold by cyanamide and by SN2-type DNA alkylating agents such as MMS and DMA; induction decreased in rad6 and rad18 mutants; gene and protein are identical to DDI3 and Ddi3p" /db_xref="GeneID:855381" /db_xref="SGD:S000005279" ORIGIN 1 msqygfvrvp revekaipvv naprpravvp ppnsetarlv reyaakelta pvlnhslrvf 61 qysvaiirdq fpawdldqev lyvtcllhdi attdknmrat kmsfeyyggi lsrelvfnat 121 ggnqdyadav teaiirhqdl tgtgyittlg lilqiattld nvgsntdlih idtvsaineq 181 fprlhwlscf atvvdtensr kpwghtsslg ddfskkvicn tfgyn // LOCUS NP_014065 222 aa linear PLN 30-JUN-2025 DEFINITION putative pyridoxal 5'-phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014065 VERSION NP_014065.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183172.1 REFERENCE 1 (residues 1 to 222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 222) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10229. Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..222 /product="putative pyridoxal 5'-phosphate synthase" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /calculated_mol_wt="25077" Region 7..217 /region_name="SNO" /note="SNO glutamine amidotransferase family; pfam01174" /db_xref="CDD:334414" Site order(57..59,91,120,151..152,197,199) /site_type="active" /note="predicted active site [active]" /db_xref="CDD:153220" Site order(91,197,199) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:153220" CDS 1..222 /gene="SNO2" /locus_tag="YNL334C" /coded_by="NM_001183172.1:1..669" /note="hypothetical protein; nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin" /db_xref="GeneID:855382" /db_xref="SGD:S000005278" ORIGIN 1 mtvvigvlal qgafiehvrh vekcivenrd fyekklsvmt vkdknqlaqc daliipgges 61 tamsliaert gfyddlyafv hnpskvtwgt cagmiyisqq lsneeklvkt lnllkvkvkr 121 nafgrqaqss tricdfsnfi phcndfpatf irapvieevl dpehvqvlyk ldgkdnggqe 181 livaakqknn ilatsfhpel aendirfhdw firefvlkny sk // LOCUS NP_014066 298 aa linear PLN 30-JUN-2025 DEFINITION pyridoxine biosynthesis protein SNZ2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014066 VERSION NP_014066.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183171.1 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10230. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..298 /product="pyridoxine biosynthesis protein SNZ2" /EC_number="4.3.3.6" /calculated_mol_wt="31902" Region 6..298 /region_name="TIGR00343" /note="pyridoxal 5'-phosphate synthase, synthase subunit Pdx1" /db_xref="CDD:129443" Site order(21,40,78,150..152,213,232) /site_type="active" /db_xref="CDD:240078" Site order(55,57,65,80,83..85,88,105..109,151..153,155,158..159, 162,215,218..219,260) /site_type="other" /note="multimer interface [polypeptide binding]" /db_xref="CDD:240078" CDS 1..298 /gene="SNZ2" /locus_tag="YNL333W" /coded_by="NM_001183171.1:1..897" /experiment="EXISTENCE:genetic interaction:GO:0008615 pyridoxine biosynthetic process [PMID:30498136]" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:30498136]" /experiment="EXISTENCE:genetic interaction:GO:0042819 vitamin B6 biosynthetic process [PMID:12271461]" /note="Protein involved in thiamine and pyridoxine biosynthesis; member of a stationary phase-induced gene family where transcriptional induction precedes the diauxic shift; induced in the absence of thiamin in a Thi2/3p-dependent manner and repressed in its presence; forms a co-regulated gene pair with SNO2; interacts with Thi11p; paralog of SNZ1 and SNZ3" /db_xref="GeneID:855383" /db_xref="SGD:S000005277" ORIGIN 1 msefkvktgl aqmlkggvim dvvtpeqaii aeragacavm aleripadmr ksgqvcrmsd 61 prmikeimea vsipvmakvr ighfveaqil eelqvdyide sevltpadwt hhiekhnfkv 121 pfvcgakdlg ealrrinega amirtkgeag tgdvseavkh itkikaeiqq ykenlktesd 181 faakatelrv pvdllkttls egklpvvnfa aggvatpada allmqlgceg vfvgsgifks 241 sdpeklacai veatthydnp akllqissdl gdlmggisiq sineaggkng arlseigw // LOCUS NP_014067 340 aa linear PLN 30-JUN-2025 DEFINITION 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014067 VERSION NP_014067.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183170.1 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10231. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..340 /product="4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase" /calculated_mol_wt="38489" Region 5..255 /region_name="PBP2_THI5" /note="Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily; cd13650" /db_xref="CDD:270368" Site order(12,44,89,114,118,159..160,167,201) /site_type="other" /note="putative chemical substrate binding site [chemical binding]" /db_xref="CDD:270368" CDS 1..340 /gene="THI12" /locus_tag="YNL332W" /coded_by="NM_001183170.1:1..1023" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:12777485]" /note="Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP" /db_xref="GeneID:855384" /db_xref="SGD:S000005276" ORIGIN 1 mstdkitfll nwqptpyhip iflaqtkgyf keqgldmail eptnpsdvte ligsgkvdmg 61 lkamihtlaa kargfpvtsv aslldepftg vlylkgsgit edfqslkgkk igyvgefgki 121 qideltkhyg mkpedytavr cgmnvakyii egkidagigi ecmqqvelee ylakqgrpas 181 dakmlridkl aclgcccfct vlyicndefl kknpekvrkf lkaikkatdy vladpvkawk 241 eyidfkprln ndlsykqyqr cyayfsssly nvhrdwkkvt gygkrlailp pdyvsnytne 301 ylswpepeev sdpleaqrlm aihqekcrqe gtfkrlalpa // LOCUS NP_014068 376 aa linear PLN 30-JUN-2025 DEFINITION putative aryl-alcohol dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014068 VERSION NP_014068.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183169.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10232. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..376 /product="putative aryl-alcohol dehydrogenase" /calculated_mol_wt="41860" Region 20..338 /region_name="AKR_AKR9A3_9B1-4" /note="Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; cd19147" /db_xref="CDD:381373" Site order(35..37,71,76,103,151..152,181..182,207,235..241,292, 309..314,317,320..321) /site_type="active" /note="putative active site [active]" /db_xref="CDD:381373" Site order(71,76,103,151) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381373" CDS 1..376 /gene="AAD14" /locus_tag="YNL331C" /coded_by="NM_001183169.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0047681 aryl-alcohol dehydrogenase (NADP+) activity [PMID:29079624]" /note="Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" /db_xref="GeneID:855385" /db_xref="SGD:S000005275" ORIGIN 1 mtdlfkplpe pptelgrlrv lsktagirvs plilggasig dawsgfmgsm nkeqafelld 61 afyeaggnci dtansyqnee seiwigewma srklrdqivi atkftgdykk yevgggksan 121 ycgnhkrslh vsvrdslrkl qtdwidilyi hwwdymssie evmdslhilv qqgkvlylgv 181 sdtpawvvsa anyyatshgk tpfsvyqgkw nvlnrdferd iipmarhfgm alapwdvmgg 241 grfqskkame erkkngeglr tfvggpeqte levkisealt kiaeehgtes vtaiaiayvr 301 skaknvfpli ggrkiehlkq niealsiklt peqieylesi vpfdvgfpks ligddpavtk 361 klspltsmsa riafdn // LOCUS NP_014069 433 aa linear PLN 30-JUN-2025 DEFINITION histone deacetylase RPD3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014069 VERSION NP_014069.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183168.1 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10233. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..433 /product="histone deacetylase RPD3" /EC_number="3.5.1.98" /calculated_mol_wt="48773" Region 18..392 /region_name="RPD3-like" /note="reduced potassium dependency-3 (RPD3)-like; cd10004" /db_xref="CDD:212528" Site order(150..151,159..160,186,188,274,281,311,313) /site_type="active" /db_xref="CDD:212528" CDS 1..433 /gene="RPD3" /locus_tag="YNL330C" /gene_synonym="MOF6; REC3; SDI2; SDS6" /coded_by="NM_001183168.1:1..1302" /experiment="EXISTENCE:direct assay:GO:0000118 histone deacetylase complex [PMID:8962081]" /experiment="EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:12110674]" /experiment="EXISTENCE:direct assay:GO:0032221 Rpd3S complex [PMID:16286008|PMID:16286007]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286007|PMID:16314178|PMID:19040720|PMID:16286008]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0070211 Snt2C complex [PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0070822 Sin3-type complex [PMID:9234741]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:17908798]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11069890]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668|PMID:17908798]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:19948887]" /experiment="EXISTENCE:genetic interaction:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:15143171]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17210643|PMID:17296735]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:20398213|PMID:17121596|PMID:24358376|PMID:15141165|P MID:16314178|PMID:24881874|PMID:17158929]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:14737171]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:9150136]" /experiment="EXISTENCE:mutant phenotype:GO:0004407 histone deacetylase activity [PMID:12110674|PMID:8962081|PMID:9572144|PMID:9512514]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:24881874]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:22539722]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:14609951|PMID:19270272]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:12453428|PMID:15143171|PMID:19417103]" /experiment="EXISTENCE:mutant phenotype:GO:0034503 protein localization to nucleolar rDNA repeats [PMID:17203076]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:31553911]" /experiment="EXISTENCE:mutant phenotype:GO:0045128 negative regulation of reciprocal meiotic recombination [PMID:18515193]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20398213|PMID:17210643|PMID:17296735|PMID:17706600|P MID:15254041]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:17158929]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10512855|PMID:10388812|PMID:19372273]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:10512855|PMID:10388812|PMID:10082585]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:35477092|PMID:31553911]" /experiment="EXISTENCE:physical interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11069890]" /experiment="EXISTENCE:physical interaction:GO:0003713 transcription coactivator activity [PMID:14737171]" /experiment="EXISTENCE:physical interaction:GO:0003714 transcription corepressor activity [PMID:9150136]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /note="Histone deacetylase, component of both Rpd3S and Rpd3L complexes; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the Hmt1p methyltransferase; delays late firing of single copy origins by opposing the Fkh1/2 origin activation pathway" /db_xref="GeneID:855386" /db_xref="SGD:S000005274" ORIGIN 1 mvyeatpfdp itvkpsdkrr vayfydadvg nyaygaghpm kphrirmahs limnyglykk 61 meiyrakpat kqemcqfhtd eyidflsrvt pdnlemfkre svkfnvgddc pvfdglyeyc 121 sisgggsmeg aarlnrgkcd vavnyagglh hakkseasgf cylndivlgi iellryhprv 181 lyididvhhg dgveeafytt drvmtcsfhk ygeffpgtge lrdigvgagk nyavnvplrd 241 giddatyrsv fepvikkime wyqpsavvlq cggdslsgdr lgcfnlsmeg hancvnyvks 301 fgipmmvvgg ggytmrnvar twcfetglln nvvldkdlpy neyyeyygpd yklsvrpsnm 361 fnvntpeyld kvmtnifanl entkyapsvq lnhtprdaed lgdveedsae akdtkggsqy 421 ardlhvehdn efy // LOCUS NP_014070 1030 aa linear PLN 30-JUN-2025 DEFINITION AAA family ATPase peroxin 6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014070 VERSION NP_014070.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183167.1 REFERENCE 1 (residues 1 to 1030) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1030) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1030) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1030) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1030) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1030) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1030) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1030) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10234. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1030 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1030 /product="AAA family ATPase peroxin 6" /calculated_mol_wt="115441" Region <541..1021 /region_name="CDC48" /note="AAA family ATPase, CDC48 subfamily; TIGR01243" /db_xref="CDD:273521" Region 740..899 /region_name="RecA-like_PEX6_r2" /note="second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); cd19527" /db_xref="CDD:410935" Site order(773..780,878) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:410935" CDS 1..1030 /gene="PEX6" /locus_tag="YNL329C" /gene_synonym="PAS8" /coded_by="NM_001183167.1:1..3093" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:12808025]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12808025]" /experiment="EXISTENCE:direct assay:GO:0016558 protein import into peroxisome matrix [PMID:29321502]" /experiment="EXISTENCE:direct assay:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:0043335 protein unfolding [PMID:29321502]" /experiment="EXISTENCE:direct assay:GO:1904949 ATPase complex [PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:1990351 transporter complex [PMID:16007078]" /experiment="EXISTENCE:genetic interaction:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]" /experiment="EXISTENCE:mutant phenotype:GO:0005777 peroxisome [PMID:12808025]" /experiment="EXISTENCE:mutant phenotype:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:15634331]" /note="AAA-peroxin; heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; mutations in human PEX6 can lead to severe peroxisomal disorders and early death" /db_xref="GeneID:855387" /db_xref="SGD:S000005273" ORIGIN 1 mkasltfsls giyapcsisr diyleygdkk aeclygtirl pqygpgctpg kivhcvldds 61 lpfcsivvps klfgfmptqp tmdfcyfepi ldnvvpvlds vtflineqly sklmdlpqem 121 qqiqflhyky ninsmetvvh srdiltsglc qilncspfpq glvdftetql ilvndteqkl 181 salkyanede eyalpkigtn salsidlesl pctisrdllr paphinddns iyaftdaetl 241 lrldvtsgsf itvsnmgcvr lvklfvlllp ngfkkrtiya ppkiiasfpd csvvtisksn 301 ightdipian qvfisrvggw lqsqkcfqni ilttlkkffs eskrilcqnd lipiafdssm 361 adlniaeend esddedelgq yykndslvwf fvtsaeldcf skdnshfiid pnrtklittn 421 itnrrplpls rsnlqryygf aetfyydlhi fpyvrqlvni letsfncsqr gitlnasvll 481 hsttnnvgka tmvrfaskyl gihlleidcl sltsnsrqld stskiigyir akcenvlpya 541 spaviflahl dsilldvnan qdpeaiklqk sinfemskll ddftfkfpgt tfvgsvnnid 601 nvpssfrshm rfeilvpvps eaqrlrifqw ylsshelnrd vqqkvpvsym dnisfsslss 661 ysagltpldi ksivetarmt atarfyqesk kcgwlpqsil itqedlskat skarnefsvs 721 igapqipnvt wddiggidfv kgeildtidm plkhpelfts gmkkrsgilf ygppgtgktl 781 makaiatnfs lnffsvkgpe llnmyigese anvrrvfqka reakpcviff deidsvapkr 841 gnqgdsggvm drivsqllae ldgmstdadg vfvigatnrp dlldeallrp grfdkllylg 901 ipdtdtkqln ilealtrkfv ldndvkliel aklcpfnytg adfyalcsda mlnamsriar 961 mvekkvsqhn eltgenistr rwfdkiatke dtkvvvkmed flkaqeqltp svsraelnhy 1021 eavranfega // LOCUS NP_014071 146 aa linear PLN 30-JUN-2025 DEFINITION Mdj2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014071 VERSION NP_014071.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183166.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10235. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..146 /product="Mdj2p" /calculated_mol_wt="16343" Region 1..137 /region_name="DnaJ" /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cl02542" /db_xref="CDD:413365" Site order(117..119,124,127..128,131..132) /site_type="other" /note="HSP70 interaction site [polypeptide binding]" /db_xref="CDD:99751" CDS 1..146 /gene="MDJ2" /locus_tag="YNL328C" /coded_by="NM_001183166.1:1..441" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:16027163]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9325105]" /experiment="EXISTENCE:genetic interaction:GO:0030150 protein import into mitochondrial matrix [PMID:16027163]" /experiment="EXISTENCE:physical interaction:GO:0001405 PAM complex, Tim23 associated import motor [PMID:16027163]" /experiment="EXISTENCE:physical interaction:GO:0030150 protein import into mitochondrial matrix [PMID:16027163]" /note="Constituent of the mitochondrial import motor; associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain" /db_xref="GeneID:855388" /db_xref="SGD:S000005272" ORIGIN 1 mvlpiiiglg vtmvalsvks glnawtvykt lspltiakln nirienptag yrdalkfkss 61 lideelknrl nqyqggfapr mtepeallil disareinhl dekllkkkhr kamvrnhpdr 121 ggspymaaki neakevlers vllrkr // LOCUS NP_014072 1041 aa linear PLN 30-JUN-2025 DEFINITION Egt2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014072 VERSION NP_014072.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183165.2 REFERENCE 1 (residues 1 to 1041) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1041) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1041) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1041) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1041) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1041) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1041) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1041) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10236. On Apr 26, 2011 this sequence version replaced NP_014072.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1041 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1041 /product="Egt2p" /calculated_mol_wt="108394" CDS 1..1041 /gene="EGT2" /locus_tag="YNL327W" /coded_by="NM_001183165.2:1..3126" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:27229769]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0030428 cell septum [PMID:15452134]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:8668141]" /note="Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase; localizes in birth scars; required for proper cell separation after cytokinesis; expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner" /db_xref="GeneID:855389" /db_xref="SGD:S000005271" ORIGIN 1 mnklllhlvr visilglana ltqtqpilkd iqitdsytkt kectdpdhwf iiegqlsipk 61 gsqqnitfqv pdafssfpqe pfsikhnsns vatisrpdks tnnftisipe ksseditttf 121 nflaqltsda kskvtepksi vysfysentm fndvidyvak ntsaittdgg iyktnntawf 181 tvdlpmrtfr npvyltsqts sssdyvfdts ltkfevvtav dsfnepinai pyttvhdyst 241 edeirclfns tisgglyfrv tyftkklsts sisntvelty pdegtsvrll gkrdtsttla 301 selysesaan idsttsddtt ssdaaitpty snstlssyts qssaipevav taslssgils 361 stvdgastsa dasmsavstv sssseqasss sislsapsss nstfttpsss lsatetysii 421 ssasisvtqa syidnsttta vtqststiav ssaeklsstl sytsnvtisv ssatqhtttp 481 syvsnsttls sssvlesvis spylanttvs gassasqstn ppyvsnstts satqlatiap 541 fainitgtsi sssitntssv ssttsslssg pfvsnttvas gsyiltttte saqlteigsl 601 ipistittst ttsgtdktgs nkvassteia qsivnnssls vstintnaat aaanarnatf 661 thathsgslq psyhssslls stidtkvtta ttstsrdgss slafttglnq svvtgtdksd 721 tysvisstes aqvteydsll pistlkptvv tgtsrnstfs mvsstkltea tatdkgdays 781 visstqsaqv teygsmlpis tletptvims tdesgyftlt tctesgqate ygslipistl 841 dgsviytftg esvvvgystt vgaaqyaqht slvpvstikg sktslstees vvagysttvg 901 aaqyaqhtsl vpvstikgsk tslsteesvv agysttvdsa qyaehtnlva idtlktstfq 961 katatevcvt ctalssphsa tldagttisl ptssstslst iitwysssti kppsistysg 1021 aagqltirig slllglisfl l // LOCUS NP_014073 336 aa linear PLN 30-JUN-2025 DEFINITION palmitoyltransferase PFA3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014073 VERSION NP_014073.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183164.1 REFERENCE 1 (residues 1 to 336) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 336) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 336) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 336) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 336) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10237. Method: conceptual translation. FEATURES Location/Qualifiers source 1..336 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..336 /product="palmitoyltransferase PFA3" /EC_number="2.3.1.225" /calculated_mol_wt="39053" Region 1..304 /region_name="COG5273" /note="Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]" /db_xref="CDD:227598" CDS 1..336 /gene="PFA3" /locus_tag="YNL326C" /coded_by="NM_001183164.1:1..1011" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762|PMID:14562095|PMID:16301533]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:16186255]" /experiment="EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:16186255]" /experiment="EXISTENCE:direct assay:GO:0018345 protein palmitoylation [PMID:16186255]" /experiment="EXISTENCE:mutant phenotype:GO:0000324 fungal-type vacuole [PMID:16301533]" /experiment="EXISTENCE:mutant phenotype:GO:0016409 palmitoyltransferase activity [PMID:26224664]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:16186255|PMID:16301533]" /note="Palmitoyltransferase for Vac8p; required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions" /db_xref="GeneID:855390" /db_xref="SGD:S000005270" ORIGIN 1 mndrlsltsl fprclttcly iwtayitltr ihqiprwfla ltivptlava lytyykviar 61 gpgspldfpd llvhdlkaae nglelppeym skrcltlkhd grfrvcqvch vwkpdrchhc 121 sscdvcilkm dhhcpwfaec tgfrnqkffi qflmyttlya flvliytcye lgtwfnsgsf 181 nrelidfhll gvallavavf isvlaftcfs iyqvcknqtt ievhgmrryr rdleilndsy 241 gtnehlenif dlgssmanwq dimgtswlew ilpietfkyk kskhtkdekg lyfnvrpqvq 301 drllssrcle dqllrrvtpr psleadrasv eiidan // LOCUS NP_014074 879 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol-3,5-bisphosphate 5-phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014074 VERSION NP_014074.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183163.1 REFERENCE 1 (residues 1 to 879) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 879) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 879) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 879) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 879) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 879) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 879) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 879) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10238. Method: conceptual translation. FEATURES Location/Qualifiers source 1..879 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..879 /product="phosphatidylinositol-3,5-bisphosphate 5-phosphatase" /calculated_mol_wt="101615" Region 31..653 /region_name="COG5329" /note="Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]" /db_xref="CDD:227637" CDS 1..879 /gene="FIG4" /locus_tag="YNL325C" /coded_by="NM_001183163.1:1..2640" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14528018]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [PMID:14528018]" /experiment="EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:14528018]" /experiment="EXISTENCE:direct assay:GO:0070772 PAS complex [PMID:19037259]" /experiment="EXISTENCE:genetic interaction:GO:0046856 phosphatidylinositol dephosphorylation [PMID:11950935]" /experiment="EXISTENCE:physical interaction:GO:0070772 PAS complex [PMID:19037259]" /note="Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain; homologous to human FIG4, which is associated with CMT4J, a form of Charcot-Marie-Tooth disorder" /db_xref="GeneID:855392" /db_xref="SGD:S000005269" ORIGIN 1 mnndamehtl gggilttsgs kqrktskfvm gkytlyetkd rmyivgsnkr etmfrileid 61 ltvprgeltv lednvfftrn eimnvlasle eatedglhkk itgygllgfi kftcwyylim 121 vtkysqvavi gghgiyhidg idiipitnny kkpekssdea rllnifkdld ltktfyfsyt 181 yditntlqtn ilreklkavd rcditipcgi tdynemfvwn nnllspifac idtvfdwfqc 241 iihgfidqvn vsvlgksiyi tliarrshhf agarflkrgv nnkghvanev eteqivtdmi 301 ltpfhqpgng ffdsdrytsf vqhrgsiply wtqdasnltt kppirinvvd pffspaalhf 361 dnlfqryggg tiqilnlikt kektpretkl lwefeqcidy lneflptlkk ldytswdmsr 421 askqdgqgvi eflekyavnt vtttgifhng pdfastkiqe gicrsncidc ldrtnaaqfv 481 igkralgcql kslgiidnsy leydsdivni ltelfhdlgd tialqyggsh lvntmetyrk 541 inqwsshsrd miesikrfys nsfvdaqrqd ainlflghys wregfpslwe mntdfylhna 601 yslnmpkrsy ihwwndynik svkelineel iatgndvtre kiiknvrgyp gafdnywney 661 ylprsvtwir dlfaynmnst rryhnalskq dkamspftsr kqswlnnklk mitsskslek 721 aegrvvettd ldrdtspkqe lelyehylhi isdrsqklee kmnsfsysky pifishesse 781 ippmrkvige plvdiaedft dvydddddgd dendemttea lliapdhvsv dekfyekvln 841 vddykpaldd ysavihikpd nlqlyrdlcf skdiqldfq // LOCUS NP_014076 414 aa linear PLN 30-JUN-2025 DEFINITION Lem3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014076 VERSION NP_014076.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183161.1 REFERENCE 1 (residues 1 to 414) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 414) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 414) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 414) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10239. Method: conceptual translation. FEATURES Location/Qualifiers source 1..414 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..414 /product="Lem3p" /calculated_mol_wt="47307" Region 11..414 /region_name="CDC50" /note="Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal transduction mechanisms]; COG5035" /db_xref="CDD:227368" CDS 1..414 /gene="LEM3" /locus_tag="YNL323W" /gene_synonym="BRE3; ROS3" /coded_by="NM_001183161.1:1..1245" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12133835|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12133835]" /experiment="EXISTENCE:genetic interaction:GO:0044088 regulation of vacuole organization [PMID:25359886]" /experiment="EXISTENCE:mutant phenotype:GO:0007166 cell surface receptor signaling pathway [PMID:11063677]" /experiment="EXISTENCE:mutant phenotype:GO:0015247 aminophospholipid flippase activity [PMID:12133835]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:12842877]" /experiment="EXISTENCE:mutant phenotype:GO:0140345 phosphatidylcholine flippase activity [PMID:12133835]" /experiment="EXISTENCE:physical interaction:GO:1990531 phospholipid-translocating ATPase complex [PMID:15090616]" /note="Membrane protein of the plasma membrane and ER; interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane; null mutant requires tryptophan due to mislocalization of tryptophan permease Tat2p" /db_xref="GeneID:855393" /db_xref="SGD:S000005267" ORIGIN 1 mvnfdlgqvg evfrrkdkga ivsgdnpeee edvdasefee devkpvrtkn rrpkedaftq 61 qrlaainpvl tprtvlplyl liavvfvivg gcilaqnskv devtiyyqdc mtnatsswsd 121 ipsehwqfvf hkyktyntap qwrfvddesd dftkqrgtcq irfttpsdmk nnvylnyvle 181 kfaanhrryv lsfsedqirg edasyetvhd atginckpls knadgkiyyp cgliansmfn 241 dtfplqltnv gdtsnnyslt nkginwesdk krykktkyny tqiapppywe kmypdgynet 301 nipdiqdwee fqnwmrpgaf dkitklirin kndtlpagey qldiglhwpv lefngkkgiy 361 lthgshlggr npflgivyli ggcicaamal illtfwlfgg rkiadassls wnmk // LOCUS NP_014077 313 aa linear PLN 30-JUN-2025 DEFINITION Kre1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014077 VERSION NP_014077.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183160.1 REFERENCE 1 (residues 1 to 313) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 313) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 313) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 313) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10240. Method: conceptual translation. FEATURES Location/Qualifiers source 1..313 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..313 /product="Kre1p" /calculated_mol_wt="32027" Region 224..286 /region_name="KRE1" /note="Killer toxin-resistance protein 1; pfam17056" /db_xref="CDD:407226" CDS 1..313 /gene="KRE1" /locus_tag="YNL322C" /coded_by="NM_001183160.1:1..942" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11956747]" /note="Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor" /db_xref="GeneID:855394" /db_xref="SGD:S000005266" ORIGIN 1 mmrrtllhsf atlllslslw saavmaavtt qvtvvtnvag alvtettiwd pataaaaatt 61 taqtgffttv ftttndvgtt vtltqtvnra tmlpttttst sstgkttttv ptatsslssg 121 lylstvtttn dlgttvtltq tfthsstsat ssasssvsss vsssgssssv ktttstgsav 181 aetgtrpdps tdfteppvsa vtslsidsyi titegttsty tttraptsmw vtvvrqgnti 241 tvqttfvqrf ssqyvtvasp svgsigmgtl tgtvgviksa ikktvshnea qhlgmssfts 301 ilgglltvli wfl // LOCUS NP_014078 908 aa linear PLN 30-JUN-2025 DEFINITION calcium/hydrogen antiporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_014078 VERSION NP_014078.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183159.1 REFERENCE 1 (residues 1 to 908) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 908) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 908) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 908) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 908) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 908) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 908) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 908) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10241. Method: conceptual translation. FEATURES Location/Qualifiers source 1..908 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..908 /product="calcium/hydrogen antiporter" /calculated_mol_wt="102368" Region 239..296 /region_name="YccF" /note="Inner membrane component domain; pfam03733" /db_xref="CDD:461030" Region 549..898 /region_name="ECM27" /note="Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; COG0530" /db_xref="CDD:440296" Region 744..902 /region_name="Na_Ca_ex" /note="Sodium/calcium exchanger protein; pfam01699" /db_xref="CDD:426387" CDS 1..908 /gene="VNX1" /locus_tag="YNL321W" /coded_by="NM_001183159.1:1..2727" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:17588950]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20709757|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:20578725]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:mutant phenotype:GO:0006813 potassium ion transport [PMID:17588950]" /experiment="EXISTENCE:mutant phenotype:GO:0006814 sodium ion transport [PMID:17588950]" /experiment="EXISTENCE:mutant phenotype:GO:0015369 calcium:proton antiporter activity [PMID:20578725]" /experiment="EXISTENCE:mutant phenotype:GO:0015385 sodium:proton antiporter activity [PMID:17588950]" /experiment="EXISTENCE:mutant phenotype:GO:0015386 potassium:proton antiporter activity [PMID:17588950]" /experiment="EXISTENCE:mutant phenotype:GO:1902600 proton transmembrane transport [PMID:20578725]" /note="Calcium/H+ antiporter localized to endoplasmic reticulum membrane; member of calcium exchanger (CAX) family; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:855395" /db_xref="SGD:S000005265" ORIGIN 1 maknnhisas gnstsgdhrl keevltptts astphrifsv dddpkeiqnd iryleglheg 61 lkfalhanks krsvssqspi vhssnntlhh hehqqhlppt leslsskshs vpdlntatps 121 spkrmhssir elphddndde danddsrfii hdshghdlli deincqspsh lenndqasna 181 sstesftlre rqdainethp fgiriwkpal ykkhrsvqrt aaqdihetql ktitwevtcs 241 nvlwfilfgf piailfysaa ivvfllgggg lvtnsakeys kclyklanyf lwpfgkmvyl 301 lqdeqylqed kdegismqqf ynwvtsysnr lvfhqsqakf qqredhpapa tessslmppa 361 nttatplnsn hpsynsirhe iphaaaqrry fgrgkwswgr vlfytifhlv lqpilavlsl 421 clwllvftip msnvlwqimy hcrrhplalg fkyvenssqs heneitqqql nknillctfr 481 aagwhyykyt vdgtnvivvn lisivfftif dfyvlknflh wktwftyess ifilcltsti 541 plafyigqav asisaqtsmg vgavinaffs tiveiflycv alqqkkgllv egsmigsilg 601 avlllpglsm cggalnrktq rynpasagvs sallifsmiv mfvptvlyei yggysvncad 661 gandrdctfs hpplkfnrlf thviqpmsis caivlfcayi iglwftlrth akmiwqlpia 721 dptstapeqq eqnshdapnw srskstcill mstllyaiia eilvscvdav ledipslnpk 781 flgltifali pntteflnai sfaihgnval smeigsayal qvcllqipsl viysifytwn 841 vkksminirt qmfplvfprw difgamtsvf mftylyaegk snyfkgsmli llyiiivvgf 901 yfqgalse // LOCUS NP_014079 284 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL320W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014079 VERSION NP_014079.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183158.1 REFERENCE 1 (residues 1 to 284) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 284) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 284) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 284) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10242. Method: conceptual translation. FEATURES Location/Qualifiers source 1..284 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..284 /product="uncharacterized protein" /calculated_mol_wt="32177" Region 49..278 /region_name="FrsA" /note="Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; COG1073" /db_xref="CDD:440691" CDS 1..284 /locus_tag="YNL320W" /coded_by="NM_001183158.1:1..855" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:855396" /db_xref="SGD:S000005264" ORIGIN 1 mlwkvskmfl gglvalttis vatlyhyqnr lvypswaqga rnhvdtpdsr gipyekltli 61 tqdhikleaw diknenstst vlilcpnagn igyfiliidi fyrqfgmsvf iysyrgygns 121 egspsekglk ldadcvishl stdsfhskrk lvlygrslgg analyiaskf rdlcdgvile 181 ntflsirkvi pyifpllkrf tllcheiwns eglmgscsse tpflflsglk deivppfhmr 241 klyetcpssn kkifefplgs hndtiiqdgy wdiirdflie kgfi // LOCUS NP_014081 540 aa linear PLN 30-JUN-2025 DEFINITION Hxt14p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014081 VERSION NP_014081.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183156.1 REFERENCE 1 (residues 1 to 540) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 540) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 540) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 540) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10243. Method: conceptual translation. FEATURES Location/Qualifiers source 1..540 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..540 /product="Hxt14p" /calculated_mol_wt="60848" Region 62..537 /region_name="MFS_HXT" /note="Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; cd17356" /db_xref="CDD:340914" Site order(74,78,212,215..216,219,352..353,357..358,361..362, 387,449..450,453..454,458,481..482,485) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..540 /gene="HXT14" /locus_tag="YNL318C" /coded_by="NM_001183156.1:1..1623" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005354 galactose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /note="Protein with similarity to hexose transporter family members; expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:855398" /db_xref="SGD:S000005262" ORIGIN 1 mtaqipyqhs sgyishfhnn eldagrgrdy nvtikylddk eeniegqaak ishnaslhip 61 vllclvislg gfifgwdigt iggmtnmvsf qekfgttnii hddetifvst kkltdlqigl 121 iisifniscg vgaltlskig dwigrkggiw falvvycigi tiqilsygrw yfltlgravt 181 gigvgvttvl vpmflsensp lkirgsmvst yqlivtfgil mgnilnfice rcykdptqni 241 awqlplflgy iwaiiigmsl vyvpespqyl akikndvpsa kysfarmngi patdsmvief 301 iddllennyn neetnneskk qslvkrntfe fimgkpklwl rliigmmima fqqlsginyf 361 fyygtsvfkg vgikdpyits iilssvnfls tilgiyyvek wghktcllyg stnllfymmt 421 yatvgtfgre tdfsnivlii vtccfifwfa itlgpvtfvl vselfplrtr aismaictfi 481 nwmfnflisl ltpmivskid fklgyifaac llaliifswi lvpetrkkne qeinkifepe // LOCUS NP_014082 465 aa linear PLN 30-JUN-2025 DEFINITION cleavage polyadenylation factor subunit PFS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014082 VERSION NP_014082.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183155.1 REFERENCE 1 (residues 1 to 465) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 465) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 465) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 465) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10244. Method: conceptual translation. FEATURES Location/Qualifiers source 1..465 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..465 /product="cleavage polyadenylation factor subunit PFS2" /calculated_mol_wt="53012" Region 93..377 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Region 98..133 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Site order(110,114,120..121,133..134,152,156,162..163,175..176, 193,198,204..205,218,235,240,246..247,259..260,279,283, 289..290,302..303,321,326,332..333,348..349,367,371,377) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 139..175 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 180..216 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 223..257 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 264..299 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 307..346 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 353..377 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..465 /gene="PFS2" /locus_tag="YNL317W" /coded_by="NM_001183155.1:1..1398" /experiment="EXISTENCE:curator inference:GO:0003723 RNA binding [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11344258]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:10619842]" /note="Integral subunit of the pre-mRNA CPF complex; the cleavage and polyadenylation factor (CPF) complex plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex" /db_xref="GeneID:855399" /db_xref="SGD:S000005261" ORIGIN 1 mdghnqnqyq nqnqiqqsqq pplkkyvtqr rsvdvsspyi nlyynrrhgl pnlvvepets 61 ytidimppna yrgrdrvinl pskfthlssn kvkhvipaiq wtpegrrlvv atysgefslw 121 nassftfetl mqahdsavtt mkyshdsdwm isgdadgmik iwqpnfsmvk eidaahtesi 181 rdmafssnds kfvtcsddni lkiwnfsngk qervlsghhw dvkscdwhpe mgliasaskd 241 nlvklwdprs gncissilkf khtvlktrfq ptkgnllmai skdkscrvfd irysmkelmc 301 vrdetdymtl ewhpinesmf tlacydgslk hfdllqnlne piltipyahd kcitslsynp 361 vghifataak drtirfwtra rpidpnaydd ptynnkking wffginndin avreksefga 421 appppatlep halpnmngfi nkkprqeipg idsniksstl pglsi // LOCUS NP_014083 334 aa linear PLN 30-JUN-2025 DEFINITION prephenate dehydratase PHA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014083 VERSION NP_014083.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183154.1 REFERENCE 1 (residues 1 to 334) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 334) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 334) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 334) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10245. On Oct 2, 2003 this sequence version replaced NP_014083.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..334 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..334 /product="prephenate dehydratase PHA2" /EC_number="4.2.1.51" /calculated_mol_wt="38094" Region 7..226 /region_name="PBP2_PDT_like" /note="Catalytic domain of prephenate dehydratase and similar proteins; the type 2 periplasmic binding protein fold; cd13532" /db_xref="CDD:270250" Site order(11,39..40) /site_type="active" /db_xref="CDD:270250" Site order(39,45,61,139,141,145,160,164..166) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:270250" Region 243..326 /region_name="ACT_CM-PDT" /note="C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; cd04905" /db_xref="CDD:153177" Site order(254..257,274..277) /site_type="other" /note="putative L-Phe binding site [chemical binding]" /db_xref="CDD:153177" CDS 1..334 /gene="PHA2" /locus_tag="YNL316C" /coded_by="NM_001183154.1:1..1005" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004664 prephenate dehydratase activity [PMID:1532796]" /experiment="EXISTENCE:mutant phenotype:GO:0009094 L-phenylalanine biosynthetic process [PMID:1532796]" /note="Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway" /db_xref="GeneID:855400" /db_xref="SGD:S000005260" ORIGIN 1 masktlrvlf lgpkgtyshq aalqqfqsts dveylpaasi pqcfnqlend tsidysvvpl 61 enstngqvvf sydllrdrmi kkalslpapa dtnritpdie viaeqyvpit hclispiqlp 121 ngiaslgnfe eviihshpqv wgqvecylrs maekfpqvtf irldcsstse svnqcirsst 181 adcdnilhla iasetaaqlh kayiiehsin dklgnttrfl vlkrrenagd nevedtgllr 241 vnlltfttrq ddpgslvdvl nilkihslnm csinsrpfhl dehdrnwryl ffieyytekn 301 tpknkekfye disdkskqwc lwgtfprner yyhk // LOCUS NP_014084 318 aa linear PLN 30-JUN-2025 DEFINITION Atp11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014084 VERSION NP_014084.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183153.1 REFERENCE 1 (residues 1 to 318) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 318) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 318) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 318) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10246. Method: conceptual translation. FEATURES Location/Qualifiers source 1..318 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..318 /product="Atp11p" /calculated_mol_wt="36720" Region 40..310 /region_name="ATP11" /note="ATP11 protein; pfam06644" /db_xref="CDD:461972" CDS 1..318 /gene="ATP11" /locus_tag="YNL315C" /coded_by="NM_001183153.1:1..957" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:1532796]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:12829692|PMID:10681564]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:2142305]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:2142305]" /experiment="EXISTENCE:physical interaction:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:10681564]" /note="Molecular chaperone; required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; N-terminally propionylated in vivo" /db_xref="GeneID:855401" /db_xref="SGD:S000005259" ORIGIN 1 mwrltrkigt rihisnqlsp ifnkaigtvp vfrfyssspe qkyrkkllee aqkqgfnsie 61 elknhlketi eskkrefnki dplkeledyq qktqmennns khlmtksrsp ldpsapkvpf 121 ktldsfldvg klkdlskqev eflwrarwaq kdntlcavip vsvydkmman arnnpifvlp 181 lprqvqseda kpneeqgmel hyiqwqfvgp qtthcmmtsl aeyklhqefa rphttlqfhs 241 dlvkdkgivf mnghvepdtn vnvqdaqlll lnvqrfygam geetpvakqr vqllrdfska 301 spgftvekli slsqsmen // LOCUS NP_014085 255 aa linear PLN 30-JUN-2025 DEFINITION Dal82p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014085 VERSION NP_014085.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183152.1 REFERENCE 1 (residues 1 to 255) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 255) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 255) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 255) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 255) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10247. Method: conceptual translation. FEATURES Location/Qualifiers source 1..255 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..255 /product="Dal82p" /calculated_mol_wt="28948" CDS 1..255 /gene="DAL82" /locus_tag="YNL314W" /coded_by="NM_001183152.1:1..768" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10702289]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:8367295]" /experiment="EXISTENCE:mutant phenotype:GO:0000256 allantoin catabolic process [PMID:1898922]" /experiment="EXISTENCE:mutant phenotype:GO:0043565 sequence-specific DNA binding [PMID:10702289]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10906145]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10906145]" /note="Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain" /db_xref="GeneID:855402" /db_xref="SGD:S000005258" ORIGIN 1 mdesvdpvel llrllirhkp hlkpyayrqd swqrvldeyn rqtgsryrqs rtlktkfrrl 61 kdlfsadraq fspsqlklmg alldeapehp rprtkfgnes ssslssssfi kshpgpdpfq 121 qlssaehpnn hssddehsgs qplpldsiti gipptlhtip milskdndvg kvikspkink 181 gtnrfsetvl ppqmaaeqsw sdsnmeleic ldylhnelev ikkrqedfec kvlnklniie 241 allsqmrpps qgdki // LOCUS NP_014086 904 aa linear PLN 30-JUN-2025 DEFINITION tetratricopeptide repeat-containing protein EMW1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014086 VERSION NP_014086.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183151.1 REFERENCE 1 (residues 1 to 904) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 904) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 904) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 904) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 904) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10248. Method: conceptual translation. FEATURES Location/Qualifiers source 1..904 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..904 /product="tetratricopeptide repeat-containing protein EMW1" /calculated_mol_wt="102206" Region 515..703 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 596..631 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(597,600..601,604..605,607,638,641..642,645..646, 648..649,672,675..676,679..680,683) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 636..666 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 671..699 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 706..734 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..904 /gene="EMW1" /locus_tag="YNL313C" /coded_by="NM_001183151.1:1..2715" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:14690591|PMID:21273246]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:21273246|PMID:14690591|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:21273246]" /note="Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855403" /db_xref="SGD:S000005257" ORIGIN 1 metllhakll lsaeveslks gsfdqtyvkk aehiisgesy qlvqqfvdkf kgkisisgei 61 stssviaaln dflnvevfkm gqenemlfla iallqtfiqn nytgpaarlk aisglfgktg 121 ieigavntal srslaimgqp ayefmddply lvlsllller itgqkslfdv tpdqeiplpi 181 isaestpgll avaywwwara lltqlslipe psgfqasvas aiyqsadlay aitkelpesi 241 hedfkrelca myylenvkcs laintehlcl psltrakkit nfefvmtgar atrtkyqqka 301 hagliilaks ftfqnfalrt tsatpetfal esdlllekph fesiadepld eqiyskrqkv 361 dlnegyeedk llplalrqen ipkllldlnp ndqptlsdyd niqlllrlyt iknttpakdp 421 lveeeltall srilyqngdk nwsifarslw ersiiettka ktiergllqm qslveeldlk 481 iksklvpsss einvasrlsy ihqlpfiprw qldatlaeky mslgilksav eiyerlgmac 541 etalcyaavg dekkaeeill qrinendsda raysilgdik qdpslweksw eigkyvnakn 601 slakyyfnpp pksgaqpnys atlkhlndsl rqyplsfetw yfygcvglqc gkmqiaaeaf 661 trcvsldpyh alswsnlsaa ytkmdklkea ysclkraisc daqknwkiwe nymlvavkln 721 ewedvltack qlvsirrdks gegsidlpii eklvellvts eypeepqqls yfqksctefi 781 cntlpqvitt sarcwrlvar velwrkrpwa alechekayr aishnpdlev eekvwndtvd 841 acedlvaaye slgemegkyg pgslvckdwk ykcrstikal mskgkgrwdd spgwdrlvea 901 rsqi // LOCUS NP_014087 273 aa linear PLN 30-JUN-2025 DEFINITION Rfa2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014087 VERSION NP_014087.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183150.1 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10249. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..273 /product="Rfa2p" /calculated_mol_wt="29805" Region 1..273 /region_name="RFA2" /note="Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]; COG5235" /db_xref="CDD:227560" CDS 1..273 /gene="RFA2" /locus_tag="YNL312W" /gene_synonym="BUF1; RPA2; RPA32" /coded_by="NM_001183150.1:1..822" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:9679065]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:7761422]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:8804316]" /experiment="EXISTENCE:direct assay:GO:0005662 DNA replication factor A complex [PMID:2554144]" /experiment="EXISTENCE:direct assay:GO:0006260 DNA replication [PMID:2554144]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]" /experiment="EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:8910442]" /experiment="EXISTENCE:direct assay:GO:0030491 heteroduplex formation [PMID:12226081]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:7761422]" /experiment="EXISTENCE:genetic interaction:GO:0000724 double-strand break repair via homologous recombination [PMID:9679065]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:14702040]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:9093844]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:9093844]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:8910442]" /experiment="EXISTENCE:mutant phenotype:GO:0007004 telomere maintenance via telomerase [PMID:14702040]" /experiment="EXISTENCE:mutant phenotype:GO:0010833 telomere maintenance via telomere lengthening [PMID:22354040]" /experiment="EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:14702040]" /experiment="EXISTENCE:physical interaction:GO:0000722 telomere maintenance via recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0006312 mitotic recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0007131 reciprocal meiotic recombination [PMID:2554144]" /experiment="EXISTENCE:physical interaction:GO:0016567 protein ubiquitination [PMID:18342608]" /note="Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination; RPA protects against inappropriate telomere recombination, and upon telomere uncapping, prevents cell proliferation by a checkpoint-independent pathway; in concert with Sgs1p-Top2p-Rmi1p, stimulates DNA catenation/decatenation activity of Top3p; protein abundance increases in response to DNA replication s" /db_xref="GeneID:855404" /db_xref="SGD:S000005256" ORIGIN 1 matyqpyney ssvtgggfen sesrpgsges etntrvntlt pvtikqiles kqdiqdgpfv 61 shnqelhhvc fvgvvrnitd htanifltie dgtgqievrk wsedandlaa gnddssgkgy 121 gsqvaqqfei ggyvkvfgal kefggkkniq yavikpidsf nevlthhlev ikchsiasgm 181 mkqplesasn nngqslfvkd dndtssgssp lqrilefckk qcegkdansf avpiplisqs 241 lnldettvrn ccttltdqgf iyptfddnnf fal // LOCUS NP_014088 763 aa linear PLN 30-JUN-2025 DEFINITION putative SCF ubiquitin ligase complex subunit SKP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014088 VERSION NP_014088.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183149.1 REFERENCE 1 (residues 1 to 763) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 763) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 763) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 763) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10250. Method: conceptual translation. FEATURES Location/Qualifiers source 1..763 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..763 /product="putative SCF ubiquitin ligase complex subunit SKP2" /calculated_mol_wt="88811" Region 60..100 /region_name="F-box-like" /note="pfam12937" /db_xref="CDD:463757" CDS 1..763 /gene="SKP2" /locus_tag="YNL311C" /coded_by="NM_001183149.1:1..2292" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:20936605]" /experiment="EXISTENCE:mutant phenotype:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:20936605]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:14747994]" /note="F-box hypothetical protein; predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments" /db_xref="GeneID:855405" /db_xref="SGD:S000005255" ORIGIN 1 mkrlqlfgrs kyfslvssaa keeeeeeegc adaksllhst shdiksrslr fndksslmcl 61 ptkvlllilr tldfntlvtl cqvnsrfynl itneflfqnv ildsklsllk fnalihsefh 121 tsnivthsgd cstqsrsqna rflvrsiefk npqsqdsllk yskfynksgq dsiiagsykl 181 dsydkdvkkl nnirlndetp iitserikll dklesnyfhy tyielmldii dylpnltrvi 241 lsdvepnfki plwysvfndg srdffkkiik gqqsitnedl rtfqlskkfv keyeskyysl 301 prlkileika nnkrqrtfnr qrhhqklvlr pslfccfgii nelklenvti dtesldtpme 361 flplflkned nelyslqspi taltldscdv vpgngilrlf hsyfkmvkhl sllkinskfd 421 lllcscfpsl snltidcnsk cftneqvvge syyfqqrsld teddfddcns mtetlfeaps 481 dskiitpppt ssvvlslnln yisrttgndv snnpspdnnk kpamltaaql qnfqrqripe 541 fhsfyhyyrl lwerlpskni sinvinipft nvyplsplsf wehlartits vdetdedvgd 601 endqetligy ennsirdnip nanavpnlst vmspesdihh tyywnnsvrr clrdsliklk 661 nrtieyrdld veeflqnvtl enffndfqdp enfkdipnin lwcflrnlsk fkavkirmlr 721 hfslctprtr ydwelllkpv lrvnvpievr dkdgfvlysy gqk // LOCUS NP_014089 174 aa linear PLN 30-JUN-2025 DEFINITION Zim17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014089 VERSION NP_014089.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183148.1 REFERENCE 1 (residues 1 to 174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 174) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10251. On May 22, 2006 this sequence version replaced NP_014089.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..174 /product="Zim17p" /calculated_mol_wt="19724" Region 70..133 /region_name="zf-DNL" /note="DNL zinc finger; pfam05180" /db_xref="CDD:461571" CDS 1..174 /gene="ZIM17" /locus_tag="YNL310C" /gene_synonym="HEP1; TIM15" /coded_by="NM_001183148.1:1..525" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:15992824|PMID:15383543]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:15719019]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:15719019]" /experiment="EXISTENCE:mutant phenotype:GO:0006986 response to unfolded protein [PMID:15992824]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:15719019]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:15383543]" /experiment="EXISTENCE:mutant phenotype:GO:0050821 protein stabilization [PMID:16460754]" /note="Protein co-chaperone with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix; required for the maintenance of Ssc1p solubility and assists in the functional interaction of Ssc1p with substrate proteins" /db_xref="GeneID:855406" /db_xref="SGD:S000005254" ORIGIN 1 miprtrtllq skipitryfa rcwaprvryn vcrtlpaaal htniiahnev kkddkkvhlg 61 sfkvdkpkmm iaftckkcnt rsshtmskqa yekgtvlisc phckvrhlia dhlkifhdhh 121 vtveqlmkan geqvsqdvgd lefedipdsl kdvlgkyakn nsenasqlph psqk // LOCUS NP_014090 420 aa linear PLN 30-JUN-2025 DEFINITION Stb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014090 VERSION NP_014090.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183147.1 REFERENCE 1 (residues 1 to 420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 420) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10252. On Oct 2, 2003 this sequence version replaced NP_014090.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..420 /product="Stb1p" /calculated_mol_wt="45553" CDS 1..420 /gene="STB1" /locus_tag="YNL309W" /coded_by="NM_001183147.1:1..1263" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030907 MBF transcription complex [PMID:18794370]" /experiment="EXISTENCE:direct assay:GO:0033309 SBF transcription complex [PMID:18794370]" /experiment="EXISTENCE:direct assay:GO:0070822 Sin3-type complex [PMID:9393435]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10409718]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10409718]" /experiment="EXISTENCE:genetic interaction:GO:0031496 positive regulation of mating type switching [PMID:9393435]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9393435]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:18794370]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:18794370]" /experiment="EXISTENCE:physical interaction:GO:0003713 transcription coactivator activity [PMID:18794370|PMID:10409718|PMID:12832490]" /experiment="EXISTENCE:physical interaction:GO:0070822 Sin3-type complex [PMID:9393435]" /note="Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication" /db_xref="GeneID:855407" /db_xref="SGD:S000005253" ORIGIN 1 msqpqmspek eqelaskilh raelaqmtrq lklglsnvps tkrkqdsttk krsgedaedv 61 dedhktllea ispakkplhd dtnkmtvisp vkfvekpntp pssrqrkaed rsqqikprke 121 dtpstprasa tpiilphass hyqrphdknf mtpkrnnnns snhsnnnnni kkkaagskda 181 pqdsdntaga dllmylatsp ynksshhgtp mavrmpttpr syhyasqlsl ngntastsnd 241 avrfshikps asspqstfks nllpnfpdes lmdspslyls nnngsvqatl spqqrrkptt 301 ntlhppsnvp ttpsrelngt nfnllrtpnf nmgdylhnlf spsprvpaqq gasntsasip 361 svpamvpgss sntsaiataa isshttnnfl dmnangipli vgpgtdrige gesiddkltd // LOCUS NP_014091 591 aa linear PLN 30-JUN-2025 DEFINITION Kri1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014091 VERSION NP_014091.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183146.1 REFERENCE 1 (residues 1 to 591) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 591) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 591) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 591) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10253. Method: conceptual translation. FEATURES Location/Qualifiers source 1..591 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..591 /product="Kri1p" /calculated_mol_wt="68523" Region <326..397 /region_name="Kri1" /note="KRI1-like family; pfam05178" /db_xref="CDD:461569" Region <474..543 /region_name="Kri1_C" /note="KRI1-like family C-terminal; pfam12936" /db_xref="CDD:463756" CDS 1..591 /gene="KRI1" /locus_tag="YNL308C" /coded_by="NM_001183146.1:1..1776" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11027267]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:22180534]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11027267]" /note="Essential nucleolar protein required for 40S ribosome biogenesis; associate with snR30; physically and functionally interacts with Krr1p" /db_xref="GeneID:855408" /db_xref="SGD:S000005252" ORIGIN 1 mprkksaakr areqakkeaa vpatdtatik tsetsattvk paieasksyv psedeeedee 61 eeeeeddyge litdevengi nqvldaiknn ktdklldpkv kffedpesaa aklanregkh 121 kpiylkdyhr mnilsgdalk eddeeyehat vdgkqsfvsq qreektqlln eiksafsdee 181 neessgdedd gflkkkepst kkegknlpdp tvneenflee fvnqqawipk kgdkvisldl 241 nnneeddeef edaaekfena ynfryedpna aeiisyarsq atlrrsddss rrrkreekrk 301 ikeqikaeke talqkkktkk lnkltdileq ltkeygaein admvkkitdt llkndfkeee 361 wdnvvaelfn eefyqqegkp twneddeimg dfyadadgdd qteegeveke qkeedeeegp 421 krkkskkeek lqkkkekrkv nelvenaleq nklalieeve keeeerksrs rtkeeqdlkf 481 ryrevspesf gltareifaa ddtdlnefig lkkfapyrsk elrakdkrkv mkarrlrewr 541 kktfknengl apveaeagek dedtilipve kaskskhkrg hshkhkghqk k // LOCUS NP_014092 375 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine/tyrosine protein kinase MCK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014092 VERSION NP_014092.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183145.1 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10254. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..375 /product="serine/threonine/tyrosine protein kinase MCK1" /EC_number="2.7.12.1" /calculated_mol_wt="43005" Region 39..330 /region_name="STKc_GSK3" /note="The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; cd14137" /db_xref="CDD:271039" Site order(41..45,49,66,68,79,93,115..118,121,123..124,164,166, 168..169,171,183,186,197,199..202,204,242) /site_type="active" /db_xref="CDD:271039" Site order(41..44,49,66,68,93,115..118,121,166,168..169,171,183) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271039" Site order(45..46,195..203,211..212,243..247,249..250,254, 274..277) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:271039" Site order(79,123,164,166,186,197,199..202,204,242) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271039" Site order(182..192,194..204) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271039" Site order(211,246..247,249..250,253..254,274..277) /site_type="other" /note="axin binding site [polypeptide binding]" /db_xref="CDD:271039" CDS 1..375 /gene="MCK1" /locus_tag="YNL307C" /gene_synonym="CMS1; YPK1" /coded_by="NM_001183145.1:1..1128" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:23314252]" /experiment="EXISTENCE:direct assay:GO:0004712 protein serine/threonine/tyrosine kinase activity [PMID:8407952]" /experiment="EXISTENCE:genetic interaction:GO:0030163 protein catabolic process [PMID:23236290|PMID:17954914]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:36321416]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:2010084]" /experiment="EXISTENCE:mutant phenotype:GO:0004857 enzyme inhibitor activity [PMID:22918234]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:17954914|PMID:23236290]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:2010083]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:2010083]" /experiment="EXISTENCE:physical interaction:GO:0030332 cyclin binding [PMID:22918234]" /note="Dual-specificity S/T and tyrosine protein kinase; spindle position checkpoint component that works in parallel with Kin4p to prevent mitotic exit network (MEN) activation by the Cdc14 early anaphase release (FEAR) network; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent degradation of Rcn1p and Cdc6p, inhibition of protein kinase A, transcriptional regulation, inhibition of RNAPIII, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division" /db_xref="GeneID:855409" /db_xref="SGD:S000005251" ORIGIN 1 msteeqngvp lqrgsefiad dvtsnksnnt rrmlvkeyrk igrgafgtvv qayltqdkkn 61 wlgpfaikkv pahteyksre lqilriadhp nivklqyfft hlspqdnkvy qhlameclpe 121 tlqieinryv tnklemplkh irlytyqiar gmlylhglgv chrdikpsnv lvdpetgvlk 181 icdfgsakkl ehnqpsisyi csrfyrapel iigctqyttq idiwglgcvm gemligkaif 241 qgqepllqlr eiakllgppd krfiffsnpa ydgplfskpl fsgssqqrfe kyfghsgpdg 301 idllmkilvy epqqrlsprr ilahqffnel rnddtflprg ftepiklpnl fdfndfelqi 361 lgefadkikp tkvae // LOCUS NP_014093 217 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS11m MRPS18 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014093 VERSION NP_014093.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183144.1 REFERENCE 1 (residues 1 to 217) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 217) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 217) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 217) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10255. Method: conceptual translation. FEATURES Location/Qualifiers source 1..217 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..217 /product="mitochondrial 37S ribosomal protein uS11m MRPS18" /calculated_mol_wt="24432" Region 107..215 /region_name="Ribosomal_S11" /note="Ribosomal protein S11; cl00332" /db_xref="CDD:444843" CDS 1..217 /gene="MRPS18" /locus_tag="YNL306W" /gene_synonym="uS11m" /coded_by="NM_001183144.1:1..654" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552|PMID:9151978]" /note="Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins" /db_xref="GeneID:855410" /db_xref="SGD:S000005250" ORIGIN 1 mllqpvwkgc rwtqfvrpir rwnstgtnrg vpfsfkdisn qeditnisyp sssdsvltks 61 ngssevykpk eevvkyilhg kftknnthlt fssvvedknf hknkgltynd tmlyylnlpq 121 kvkislstgc lgfrkaarge yeaafqtsgr mfelikeknm lnkdievvmd dfgkgraafi 181 salvgkegas vvkkvvkisd atklkfggvr spkmrrl // LOCUS NP_014094 297 aa linear PLN 30-JUN-2025 DEFINITION Bxi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014094 VERSION NP_014094.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183143.1 REFERENCE 1 (residues 1 to 297) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 297) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 297) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 297) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10256. Method: conceptual translation. FEATURES Location/Qualifiers source 1..297 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..297 /product="Bxi1p" /calculated_mol_wt="33514" Region 21..294 /region_name="GAAP_like" /note="Golgi antiapoptotic protein; cd10429" /db_xref="CDD:198411" CDS 1..297 /gene="BXI1" /locus_tag="YNL305C" /gene_synonym="YBH3" /coded_by="NM_001183143.1:1..894" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:21673659|PMID:21673967|PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:21673659]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:21673967]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:21673967|PMID:21673659]" /experiment="EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:21673967]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:21673967]" /note="Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p" /db_xref="GeneID:855411" /db_xref="SGD:S000005249" ORIGIN 1 msgppppyee qsshlygqpa ssqdgnafip edfkystvvi scepiirqrf mhkvysllsc 61 qllaslsfcy wasvstslqn fimshialfy icmvvslvsc iwlavsprpe dyeasvpepl 121 ltgsseepaq eqrrlpwyvl ssykqkltll siftlseayc lslvtlaydk dtvlsallit 181 tivvvgvslt alserfenvl nsatsiyywl nwglwimigm gltallfgwn thsskfnlly 241 gwlgailfta ylfidtqlif rkvypdeevr cammlyldiv nlflsilril ansnddn // LOCUS NP_014095 417 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase YPT11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014095 VERSION NP_014095.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183142.1 REFERENCE 1 (residues 1 to 417) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 417) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 417) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 417) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10257. On Nov 30, 2005 this sequence version replaced NP_014095.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..417 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..417 /product="Rab family GTPase YPT11" /calculated_mol_wt="46985" Region 196..331 /region_name="Rab" /note="Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); cd00154" /db_xref="CDD:206640" Site order(198,205..211) /site_type="other" /note="Switch I region" /db_xref="CDD:206640" Site 205 /site_type="other" /note="G2 box" /db_xref="CDD:206640" Site order(206,208..210,225,227,234..235,239,243,248) /site_type="active" /note="effector interaction site [active]" /db_xref="CDD:206640" Site order(206..207,209,227..228,235,240..242) /site_type="active" /note="GDI interaction site [active]" /db_xref="CDD:206640" Site 206..210 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206640" Site order(207..214,221,223) /site_type="other" /note="GEF interaction site [polypeptide binding]" /db_xref="CDD:206640" Site 223..227 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206640" Site 228..231 /site_type="other" /note="G3 box" /db_xref="CDD:206640" Site order(231,233..236,239..244) /site_type="other" /note="Switch II region" /db_xref="CDD:206640" Site order(234..236,239..240) /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206640" Site 243..244 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206640" Site 252..257 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206640" Site 285..289 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206640" Site 292..295 /site_type="other" /note="G4 box" /db_xref="CDD:206640" Site 329..331 /site_type="other" /note="G5 box" /db_xref="CDD:206640" CDS 1..417 /gene="YPT11" /locus_tag="YNL304W" /coded_by="NM_001183142.1:1..1254" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12391144]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:23427260]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16980630|PMID:23427260]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12391144|PMID:23427260]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12391144|PMID:23427260]" /experiment="EXISTENCE:direct assay:GO:0048309 endoplasmic reticulum inheritance [PMID:23427260]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:18245340|PMID:23427260|PMID:12391144|PMID:15201867]" /experiment="EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:12391144|PMID:15201867]" /experiment="EXISTENCE:genetic interaction:GO:0048313 Golgi inheritance [PMID:18595704]" /experiment="EXISTENCE:genetic interaction:GO:0090167 Golgi distribution to daughter cells [PMID:18595704]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:18245340|PMID:12391144]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:16980630|PMID:23427260]" /experiment="EXISTENCE:mutant phenotype:GO:0048312 intracellular distribution of mitochondria [PMID:12391144]" /experiment="EXISTENCE:mutant phenotype:GO:0048313 Golgi inheritance [PMID:18595704]" /experiment="EXISTENCE:mutant phenotype:GO:0051646 mitochondrion localization [PMID:23139336]" /experiment="EXISTENCE:mutant phenotype:GO:0090167 Golgi distribution to daughter cells [PMID:18595704]" /experiment="EXISTENCE:physical interaction:GO:0031489 myosin V binding [PMID:12391144]" /note="Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum (ER), late Golgi, and mitochondria during cell division; function is regulated at multiple levels; abundance of active Ypt11p forms is controlled by phosphorylation status and degradation; normally a low-abundance protein whose ER localization is only detected when protein is highly over expressed" /db_xref="GeneID:855412" /db_xref="SGD:S000005248" ORIGIN 1 msqrkrysln vvtspsipsp tpsapirtne snweaaspas aassflpnvh hggtvlnpgl 61 gimrspslnk sgafgrsgss gsstviepsn ikllligdan vgktamilsy crelltraem 121 srsarlrhqq qqqhkdlglk ktvvnhrlsm kekrkryssn dfekefkdin hfadetsdfg 181 npnigddnnh emadpneivi etrstigidi ktnlvnidnr ffnvilwdta gqeryqnaii 241 pslykktnav iltyditnak sfqscmerwi vqalenfssq dllkarfflv gnkidlyker 301 qvthydvvqm vqemqlkhgi kisgnfevsc kwvnvvertm nmiildlven gcfenndpcv 361 sittsddvqg heqefhdtve epfnftrqrq hqleknntvd itkpnddian nqsiccv // LOCUS NP_014097 144 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS19 RPS19B [Saccharomyces cerevisiae S288C]. ACCESSION NP_014097 VERSION NP_014097.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183140.1 REFERENCE 1 (residues 1 to 144) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 144) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 144) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 144) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10258. Method: conceptual translation. FEATURES Location/Qualifiers source 1..144 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..144 /product="40S ribosomal protein eS19 RPS19B" /calculated_mol_wt="15760" Region 5..142 /region_name="Ribosomal_S19e" /note="Ribosomal protein S19e; pfam01090" /db_xref="CDD:460058" CDS 1..144 /gene="RPS19B" /locus_tag="YNL302C" /gene_synonym="RP55B" /coded_by="NM_001183140.1:1..435" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16159874|PMID:16246728]" /experiment="EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:16159874]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:16159874]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:16159874]" /note="Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19B has a paralog, RPS19A, that arose from the whole genome duplication" /db_xref="GeneID:855414" /db_xref="SGD:S000005246" ORIGIN 1 magvsvrdva aqdfinayas flqrqgklev pgyvdivkts sgnemppqda egwfykraas 61 varhiymrkq vgvgklnkly ggaksrgvrp ykhidasgsi nrkvlqalek igiveispkg 121 grrisengqr dldriaaqtl eede // LOCUS NP_014098 186 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL18 RPL18B [Saccharomyces cerevisiae S288C]. ACCESSION NP_014098 VERSION NP_014098.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183139.1 REFERENCE 1 (residues 1 to 186) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 186) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 186) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 186) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10259. Method: conceptual translation. FEATURES Location/Qualifiers source 1..186 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..186 /product="60S ribosomal protein eL18 RPL18B" /calculated_mol_wt="20432" Region 2..186 /region_name="Ribosomal_L18" /note="Ribosomal protein 60S L18 and 50S L18e; pfam17135" /db_xref="CDD:465358" CDS 1..186 /gene="RPL18B" /locus_tag="YNL301C" /gene_synonym="RP28B" /coded_by="NM_001183139.1:1..561" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L18B; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18B has a paralog, RPL18A, that arose from the whole genome duplication" /db_xref="GeneID:855415" /db_xref="SGD:S000005245" ORIGIN 1 mgidhtskqh krsghrtapk sdnvylkllv klytflarrt dapfnkvvlk alflskinrp 61 pvsvsriara lkqegaankt vvvvgtvtdd arifefpktt vaalrftaga rakivkagge 121 citldqlavr apkgqntlil rgprnsreav rhfgmgphkg kaprilstgr kferargrrr 181 skgfkv // LOCUS NP_014099 102 aa linear PLN 30-JUN-2025 DEFINITION Tos6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014099 VERSION NP_014099.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183138.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10260. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..102 /product="Tos6p" /calculated_mol_wt="10039" Region 4..102 /region_name="TOS6" /note="GPI-anchored protein TOS6; cd22955" /db_xref="CDD:438566" CDS 1..102 /gene="TOS6" /locus_tag="YNL300W" /coded_by="NM_001183138.1:1..309" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /note="Glycosylphosphatidylinositol-dependent cell wall protein; expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid" /db_xref="GeneID:855416" /db_xref="SGD:S000005244" ORIGIN 1 mkfstlstva aiaafasads tsdgvtyvdv tttpqsttsm vstvkttstp yttstiatls 61 tksissqant ttheistyvg aavkgsvagm gaimgaaafa ll // LOCUS NP_014100 642 aa linear PLN 30-JUN-2025 DEFINITION non-canonical poly(A) polymerase TRF5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014100 VERSION NP_014100.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183137.1 REFERENCE 1 (residues 1 to 642) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 642) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 642) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 642) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10261. On Nov 10, 2005 this sequence version replaced NP_014100.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..642 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..642 /product="non-canonical poly(A) polymerase TRF5" /EC_number="2.7.7.19" /calculated_mol_wt="74049" Region 100..611 /region_name="TRF4" /note="DNA polymerase sigma [Replication, recombination and repair]; COG5260" /db_xref="CDD:227585" CDS 1..642 /gene="TRF5" /locus_tag="YNL299W" /coded_by="NM_001183137.1:1..1929" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:16374505]" /experiment="EXISTENCE:direct assay:GO:1990817 poly(A) RNA polymerase activity [PMID:16374505|PMID:16260630]" /experiment="EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491]" /experiment="EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:17652137|PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:16373491|PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process [PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:16431988]" /experiment="EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18007593]" /experiment="EXISTENCE:genetic interaction:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:16373491]" /experiment="EXISTENCE:genetic interaction:GO:0071044 histone mRNA catabolic process [PMID:17179095]" /experiment="EXISTENCE:genetic interaction:GO:0071051 poly(A)-dependent snoRNA 3'-end processing [PMID:16373491]" /experiment="EXISTENCE:genetic interaction:GO:1990817 poly(A) RNA polymerase activity [PMID:16374505]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:15935758|PMID:18007593]" /experiment="EXISTENCE:mutant phenotype:GO:1990817 poly(A) RNA polymerase activity [PMID:16374505]" /note="Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p" /db_xref="GeneID:855417" /db_xref="SGD:S000005243" ORIGIN 1 mtrlkakysp tkgkrkedkh tkrmrkssft rtqkmlevfn dnrshfnkye slaidveddd 61 tfgnlvlmen dksdvdipvi eevtssedeq raesskrnns lednqdfiaf sdssedeteq 121 ikeddderss flltdehevs kltsqqslnt esacnveypw irnhchskqr riadwltsei 181 kdfvhyisps kneikcrnrt idklrravke lwsdadlhvf gsfatdlylp gsdidcvvns 241 rnrdkedrny iyelarhlkn kglairmevi vktrvpiikf iepqsqlhid vsfertngle 301 aaklirewlr dspglrelvl iikqflhsrr lnnvhtgglg gftviclvys flnmhpriks 361 ndidvldnlg vllidffely gknfgyddva isisdgyasy ipkscwrtle psrskfslai 421 qdpgdpnnni srgsfnmkdi kkafagafel lvnkcwelns atfkdrvgks ilgnvikyrg 481 qkrdfnderd lvqnkaiien eryhkrrtri vqedlfindt edlpveeiyk ldepakkkqk 541 akkdkregei kksaipsppp dfgvsrsklk rkvkktdqgs llhqnnlsid dlmglsendq 601 esdqdqkgrd tpsgqdeksp letktvdaqt rrdywlskgq al // LOCUS NP_014101 842 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase CLA4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014101 VERSION NP_014101.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183136.1 REFERENCE 1 (residues 1 to 842) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 842) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 842) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 842) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10262. Method: conceptual translation. FEATURES Location/Qualifiers source 1..842 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..842 /product="serine/threonine protein kinase CLA4" /EC_number="2.7.11.1" /calculated_mol_wt="93778" Region 62..174 /region_name="PH_Cla4_Ste20" /note="Pleckstrin homology (PH) domain; cd13279" /db_xref="CDD:270097" Region 183..241 /region_name="PBD" /note="P21-Rho-binding domain; pfam00786" /db_xref="CDD:395634" Site order(184,187,190,192,195,212,216) /site_type="other" /note="GTPase interaction site [polypeptide binding]" /db_xref="CDD:238526" Region 546..826 /region_name="STKc_PAK" /note="Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; cd06614" /db_xref="CDD:270789" Site order(552..556,560,592,594,623,640..644,646..647,650,693, 695..698,700,710..711,714,727..731,733,760,769..771) /site_type="active" /db_xref="CDD:270789" Site order(552..556,560,592,594,623,640..644,646..647,650, 697..698,700,710..711) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270789" Site order(555..556,693,695..697,714,727..731,733,760,769..771) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270789" Site order(710..721,726..733) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270789" CDS 1..842 /gene="CLA4" /locus_tag="YNL298W" /gene_synonym="ERC10" /coded_by="NM_001183136.1:1..2529" /experiment="EXISTENCE:direct assay:GO:0000278 mitotic cell cycle [PMID:22588722]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:19218422]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:22588722]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:19218422]" /experiment="EXISTENCE:direct assay:GO:0016301 kinase activity [PMID:14993234]" /experiment="EXISTENCE:genetic interaction:GO:0000011 vacuole inheritance [PMID:19218422]" /experiment="EXISTENCE:genetic interaction:GO:0010629 negative regulation of gene expression [PMID:19793923]" /experiment="EXISTENCE:genetic interaction:GO:0019236 response to pheromone [PMID:17189484]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:7649470]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:19218422]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0007096 regulation of exit from mitosis [PMID:12234925]" /experiment="EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0031106 septin ring organization [PMID:11025657]" /experiment="EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0042307 positive regulation of protein import into nucleus [PMID:22588722]" /experiment="EXISTENCE:mutant phenotype:GO:2000910 negative regulation of sterol import [PMID:19793923]" /note="Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication" /db_xref="GeneID:855418" /db_xref="SGD:S000005242" ORIGIN 1 mslsaaanki sdndfqnigp aprppssnsq grtcynqtqp itklmsqldl tsashlgtst 61 skkksgwvsy kddgilsfiw qkrylmlhds yvalykndkq nddailkipl tsiisvsrtq 121 lkqycfelvr csdrnsvssg sssslnvssd snskksiyia tktesdlhsw ldaifakcpl 181 lsgvssptnf thkvhvgfdp etgsfvgmpt nwekllkhsr itgedwnnns aaviqvlqfy 241 qeyngagnpt ntldkpqsge tsssqkslpn syndnklrnn svnsksssgv sssmvsqrkt 301 sqppntkspv slgsgslppi ntklptsqsn iprhlqnvpn qqypkmrngh sptngqfprg 361 pmhpnnsqrs lqqqqqqqqq qkqqhqqypy hhqgpspsps pspsplnpyr phhnminpys 421 kqpqsplssq stqnqaipry aqnssptaah fqpqrtapkp pisaprapyp snqnatsnth 481 vqpvapkndq stpqtmrqap krpdadvaqp ggvakpkkpa rptmstaeim sklkkvtvna 541 dpsqcfkvie kagqgasgsv ylaerthipt esnmielinn didephvgdk vaikqmvlsk 601 qprkelivne ilvmkdsrhk nivnfleayl rtdddlwvvm efmeggsltd iiensptndn 661 shspltepqi ayivretcqg lkflhdkhii hrdiksdnvl ldtrarvkit dfgfcarltd 721 krskratmvg tpywmapevv kqreydekid vwslgimtie mlegeppyln edplkalyli 781 atngtpklkh peslsleikr flsvclcvdv ryrasteell hhgffnmacd pkdltsllew 841 ke // LOCUS NP_014102 1636 aa linear PLN 30-JUN-2025 DEFINITION Mon2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014102 VERSION NP_014102.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183135.1 REFERENCE 1 (residues 1 to 1636) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1636) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1636) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1636) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10263. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1636 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1636 /product="Mon2p" /calculated_mol_wt="186706" Region 8..176 /region_name="DCB" /note="dimerization and cyclophilin-binding domain of Mon2; pfam16213" /db_xref="CDD:465072" Region 202..362 /region_name="Sec7_N" /note="Guanine nucleotide exchange factor in Golgi transport N-terminal; pfam12783" /db_xref="CDD:463703" Region 936..>1161 /region_name="Mon2_C" /note="C-terminal region of Mon2 protein; pfam16206" /db_xref="CDD:465066" CDS 1..1636 /gene="MON2" /locus_tag="YNL297C" /gene_synonym="YSL2" /coded_by="NM_001183135.1:1..4911" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:12052896]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16301316]" /experiment="EXISTENCE:direct assay:GO:0006623 protein targeting to vacuole [PMID:16219684]" /experiment="EXISTENCE:direct assay:GO:0031901 early endosome membrane [PMID:16219684]" /experiment="EXISTENCE:genetic interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:12052896]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:12052896]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:16301316]" /experiment="EXISTENCE:physical interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:12052896]" /note="Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins" /db_xref="GeneID:855420" /db_xref="SGD:S000005241" ORIGIN 1 mamntggfds mqrqleaelr slsseskrrn stirhasdks ieilkrvhsf eelerhpdfa 61 lpfvlacqsr nakmttlamq clqglstvps iprsrlseil dafieathla meiqlkvlqv 121 vpiffktygk fiygplckkl llccsnllhv pnkapvvvgt asatlqqlid eifdrlsies 181 vvddkqyevl isnsesikvn vyrydanklf dnicslneis sngavsdeem lldigdipid 241 ygleilesil knsqknllec qdlqyllrvk aiplllrcis ssrhfstavr scrclkllir 301 keylsilele levilsllih gisvesnlsg wqrvlslelf kdlsqdpeiv ntlymdydny 361 pdkkhvfkyl lkecivllns peyitflaps kvvekmdspl ittenstvkt kfmhlldksn 421 apsinityii slilticnhl ceglnksale ssplekkied kereegtgnd stvvkvysgl 481 fsglfelnkl flystslets ifhlvvrafq klahsagvls lkdklracmk lfsilitnnv 541 tssnqysfnd tsksaknqht rnistssvtt spvestknps rsiadsaqnk emkrrlhprn 601 issrqvsllr alislsislg pifdseswry tfltwqwity yiygpsadfk esfysedipp 661 ppiltksdvt siessltkff estssyscst fhlvltrlil dskntltleq tnlnlnndig 721 yhpldakdei ipciynkaff vnkigelaty nckkflfgkn gkelwslist ymiklisnre 781 mdndslrlyt vrvftdiikk atnevgnsde qdnkvkqfgt lenlvidslm atinsikqld 841 igkqeiyngt invesdilfq llltlkeiln efgellmnsw tnifniinsp fewtvedtdf 901 svnediddss lfegivqkhk nmiqvsydvf klisddflqs lpmsvikfvi dtlvnfvsqk 961 rnlnisfssi sqfwlvgdyl rvrfnpetln lsdekrrsls ekinnqklie iitsssshdw 1021 elynglwiyl lknlinctnd drvevkngav qtffriidsh svcfppwdli fleviepllt 1081 kewsteelen etdfinvtlq gliklypehf kdfknnttca kewsmlldfl krllsstsnn 1141 tknavilnyq tllkeiitie dvpsdilkkc ceiftdynit ysdlstnass kteydciyel 1201 itgfpplyql iskydamtde fvekvlllfn saikypllpe fvqdktkpss mqkailsgld 1261 ifmtndskdt eilillqlst isilafdtre kitkklgpkl pkaslnrlpt feaisymscs 1321 nlrnriakid qfgistlkak hilrilknla eiikrkslit gsesdeipiw vlasncfcdl 1381 snkifkslqe daenplkdnf cdlfinvivv tlqrinpeld nlteiddlne yskyreille 1441 nriidlfner qldtfiyavw dcsflyefde lenalmqdcg tfselsqkls sfdfscifgs 1501 ttnprfqtky kcsleclqdl vnfmlntnek lrkltapyls arialalrry isdeyligra 1561 pipklrktel atllnglcvi lrgvldqnst lgnkqigven lqtlsplilr tipvshkmdg 1621 lqdkvlelsl gftkld // LOCUS NP_014104 524 aa linear PLN 30-JUN-2025 DEFINITION Mrx6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014104 VERSION NP_014104.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183133.1 REFERENCE 1 (residues 1 to 524) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 524) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 524) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 524) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 524) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10264. Method: conceptual translation. FEATURES Location/Qualifiers source 1..524 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..524 /product="Mrx6p" /calculated_mol_wt="61097" Region 111..242 /region_name="Pet20" /note="Mitochondrial protein Pet20; pfam08692" /db_xref="CDD:400848" CDS 1..524 /gene="MRX6" /locus_tag="YNL295W" /coded_by="NM_001183133.1:1..1575" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:31532710]" /experiment="EXISTENCE:mutant phenotype:GO:1901858 regulation of mitochondrial DNA metabolic process [PMID:31532710]" /note="Mitochondrial ribosome-associated protein; regulates mitochondrial DNA copy number and the size and distribution of mtDNA nucleoids; subunit of a complex containing Pet20p, Mam33p, and Pim1p that may regulate mtDNA replication; member of the PET20 domain-containing protein family; forms foci that partially co-localize with mtDNA" /db_xref="GeneID:855421" /db_xref="SGD:S000005239" ORIGIN 1 mehqalrrlv lycpnfirrg alrqnmtrvs crhmsgkggg rdekgdcnee kdsskdlgrv 61 pskmkraydg etvikegdsh aeslaqqgkq ptdlaynsrs kisgsnlhll vprvastdyi 121 snkevhtegl fagyrplflg nsgfpsdark gknfhelddv lpniqvvdas ekdgklnvqe 181 iiedlqrtsl resihsmeql psshkrkpvi pwdasisgmv yndmpfkyvp kniilkmkpf 241 kllrierksq aknarkptmi klqfhnrrin dtpelvnlyh nksrlhesly ntkplqesgy 301 ssantskrqk mlkarsdfeh kqknyaykht fikndqelfr neltklnkil arefkkltkl 361 sihnefkreh lplavyvsks kgtkklfrrs lkmkimdhiy pvyttilstl tnsrdskkfe 421 nkikayieki ivrlsdevps tyffqdgvdc iiqpspihnf krmhwlrytk rhntfwgrti 481 hkdvqvsfnd kyvvtrsgvr ytryptnlnt qlletafeew dyye // LOCUS NP_014105 533 aa linear PLN 30-JUN-2025 DEFINITION Rim21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014105 VERSION NP_014105.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183132.1 REFERENCE 1 (residues 1 to 533) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 533) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 533) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 533) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 533) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10265. Method: conceptual translation. FEATURES Location/Qualifiers source 1..533 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..533 /product="Rim21p" /calculated_mol_wt="61401" Region 16..362 /region_name="PalH" /note="PalH/RIM21; pfam08733" /db_xref="CDD:400879" CDS 1..533 /gene="RIM21" /locus_tag="YNL294C" /gene_synonym="PAL2" /coded_by="NM_001183132.1:1..1602" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23019326]" /experiment="EXISTENCE:genetic interaction:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]" /experiment="EXISTENCE:genetic interaction:GO:0044088 regulation of vacuole organization [PMID:25359886]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:10821185]" /experiment="EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:16524906]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:10821185]" /experiment="EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:23019326]" /note="pH sensor molecule, component of RIM101 pathway; positive regulator of cell size; has role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH" /db_xref="GeneID:855422" /db_xref="SGD:S000005238" ORIGIN 1 mnlwrhspee laaynschpm klgsgvliql plydnsavya editfrsfcc ervpvyvstv 61 lrnsspyryl devindwqkf iqvsdyvggs aeyaiyavil sitsnfvitv fltviccini 121 sgraykrilq llriasllas lnltifitkv lrrlekehnv ygvvrahsim hifsddmtfv 181 vldflatlmf qfcqvgivir lfqraqekri iffigvilti tanilwvipp fanhttkhrn 241 dwqilrpfvy lfriaiatsy asiviyhiwq kkklwfkfnq mglltlltil vvlllpgffl 301 advsnlwise lgevfnttcy vtstvitwew ldrlnvlerk eeaqsilgrp ifeeeqqdyr 361 fakyalrvqn altrresqda stdrhdtssn sevcdlqtis rydpedqisv grsidrmhfn 421 drgtykdval kklgyardki lyftdqivqk svghnnssss knektkqrka mvrkrlgldk 481 pgiyiystkd vvfnsdeddd enaededdde yevgsegnnn ssatftsdhi ghi // LOCUS NP_014106 633 aa linear PLN 30-JUN-2025 DEFINITION Rab GTPase-activating protein MSB3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014106 VERSION NP_014106.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183131.1 REFERENCE 1 (residues 1 to 633) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 633) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 633) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 633) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10266. Method: conceptual translation. FEATURES Location/Qualifiers source 1..633 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..633 /product="Rab GTPase-activating protein MSB3" /calculated_mol_wt="72868" Region 15..540 /region_name="COG5210" /note="GTPase-activating protein [General function prediction only]" /db_xref="CDD:227535" CDS 1..633 /gene="MSB3" /locus_tag="YNL293W" /gene_synonym="GYP3" /coded_by="NM_001183131.1:1..1902" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10679030]" /experiment="EXISTENCE:direct assay:GO:0000133 polarisome [PMID:16166638]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22593206]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:22593206|PMID:10559187]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:22593206]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22593206]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22593206]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10679030|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22593206|PMID:26928762|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:35134079]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:12913108]" /experiment="EXISTENCE:genetic interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:16166638]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:22593206]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:22593206]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:22593206]" /experiment="EXISTENCE:physical interaction:GO:0006897 endocytosis [PMID:22593206]" /experiment="EXISTENCE:physical interaction:GO:0032880 regulation of protein localization [PMID:22593206]" /experiment="EXISTENCE:physical interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:16166638]" /note="Rab GTPase-activating protein; regulates endocytosis via inactivation of Vps21p at endosomes and vacuole fusion via inactivation of Ypt7p at vacuoles; also acts on Ypt52p and Sec4p; localizes to plasma membrane, sites of polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; similar to TBC-domain Tre2 oncogene; MSB3 has a paralog, MSB4, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null" /db_xref="GeneID:855423" /db_xref="SGD:S000005237" ORIGIN 1 mqndqqrfsl qnrtvlahpy krlggaftvk spsvpnfhdk mhsdhsssds alvngsfran 61 dhrsvepscl gqaspsehdg nlsvidlygd evesqraege ddddnngdng nedleevhsd 121 dldlvpdddn rqrvelegaa satsansngi nnthfdrygf kkqnnyisea eydkwwveys 181 qycvrrkhkw qllleksglp vtddspsrfp skserlkryv rkgipaewrg nawwhfargq 241 eklnknkgvy sqllrkmkqi kkqnpnekqv qdldiierdl nrtfpdnihf qsslhnkegp 301 piikslrrvl vafslynpki gycqsmnfla gllllfldee rafwmlviit srylpgvhni 361 nlegvnidqg vlmlcvkeyi pevwsyikps idhhqknnkt fspsnkkvlf nmqkneflyr 421 lppitlctas wfmscfvgvv piettlriwd clfyeeshfl fkvslavlkl sehdlskikp 481 rnnslnyswg snlnqrggsm gqedsdmeif qviqtfpktl lnpneifeki ifkrrfnlnr 541 ldqdeidrcr kfvaaqrlkf ktygellgns tseadlpind ntdnkgihit sdavnealss 601 evygfkksla gvhwnnsike kvkqmrkkkd kgd // LOCUS NP_014107 403 aa linear PLN 30-JUN-2025 DEFINITION pseudouridine synthase PUS4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014107 VERSION NP_014107.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183130.1 REFERENCE 1 (residues 1 to 403) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 403) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 403) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 403) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10267. Method: conceptual translation. FEATURES Location/Qualifiers source 1..403 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..403 /product="pseudouridine synthase PUS4" /EC_number="5.4.99.25" /calculated_mol_wt="45142" Region 3..331 /region_name="PseudoU_synth_TruB_4" /note="Pseudouridine synthase homolog 4; cd02867" /db_xref="CDD:211344" Site order(72..75,218) /site_type="active" /note="probable active site [active]" /db_xref="CDD:211344" CDS 1..403 /gene="PUS4" /locus_tag="YNL292W" /coded_by="NM_001183130.1:1..1212" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:9358157]" /experiment="EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:9358157]" /experiment="EXISTENCE:genetic interaction:GO:0009982 pseudouridine synthase activity [PMID:9358157]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:9358157]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9358157]" /experiment="EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25192136|PMID:25219674]" /note="Pseudouridine synthase; catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; also responsible for pseudouracil modification of some mRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype)" /db_xref="GeneID:855424" /db_xref="SGD:S000005236" ORIGIN 1 mngifaiekp sgitsnqfml klqhaltksq vfskeiqrat aerkqqyekq tgkkaskrkl 61 rkvskvkmgh ggtldplasg vlvigigagt kklanylsgt vkvyesealf gvsttsgdve 121 geilsqnsvk hlnfddlktv eekfvgqlkq tppiyaalkm dgkplheyar egkplpraie 181 prqvtiydlk vfsdslkrdh dypllrptte eavdtvknln anmlndvlyf skeytekhgl 241 dsevakveep fplseqeeqe iqkegdsyra pklhfkanvs sgtyirslvs digksmrssc 301 ymvklirlqq qdwsleknnv fqltdfterd ekvwskvlek vldegatvdv ieelkkaeke 361 ipadvkeciv ssdqpgdeat aetietanae ehsntlkrki eqv // LOCUS NP_014108 548 aa linear PLN 30-JUN-2025 DEFINITION Mid1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014108 VERSION NP_014108.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183129.1 REFERENCE 1 (residues 1 to 548) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 548) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 548) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 548) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10268. Method: conceptual translation. FEATURES Location/Qualifiers source 1..548 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..548 /product="Mid1p" /calculated_mol_wt="61444" Region 99..537 /region_name="Mid1" /note="Stretch-activated Ca2+-permeable channel component; pfam12929" /db_xref="CDD:432882" CDS 1..548 /gene="MID1" /locus_tag="YNL291C" /coded_by="NM_001183129.1:1..1647" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14729456]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10958666]" /experiment="EXISTENCE:direct assay:GO:0006816 calcium ion transport [PMID:10958666]" /experiment="EXISTENCE:direct assay:GO:0015275 stretch-activated, monoatomic cation-selective, calcium channel activity [PMID:10436155]" /experiment="EXISTENCE:mutant phenotype:GO:0005262 calcium channel activity [PMID:12492866|PMID:9343395]" /note="Stretch-activated Ca2+-permeable cation channel; required for Ca2+ influx stimulated by mating pheromones and some abiotic stresses; sensor of compressive mechanical stress; N-glycosylated membrane protein of the ER and plasma membrane; interacts with Cch1p; oligomerizes; is an alpha2/delta-like protein and participates in the generation of stretch-activated Ca2+-permeable cation channel activity when expressed in mammalian cells" /db_xref="GeneID:855425" /db_xref="SGD:S000005235" ORIGIN 1 mivwqalfvv yclfttsihg lfqdfnpfan knislkfpsl nrweknvmat gqqtiinsds 61 iyewtpilsn itagkkdsfv ftidaeasgy gfaptyevlm fisgnicqmp mnrsdvdlti 121 yysfnetvle npnigqsavf qdgyiqalai spvqssssna tstysnlyvv aelvnstteq 181 plsssdasen weyrlsisen dlvfqwdvrp wvevldtdmn sallstgnvt adakvyhnys 241 iydpslydly vysyedsvql nqnynlslca vkngpylvss qntsnatvts nstnplertd 301 laiqkkitey ggsvtemfyv tglnasttyv ayltkkisng dglssvggil fshvyfttrs 361 tdvcslifgl dfcsdvaysv ptssfsvgnk tlmaqtydhi aealyanfsk alqliscdad 421 kdaryspvmt cddcaeayrd wvcavsiprc tttssqyyih rdkshnrndy lnkfikpldd 481 yyeilpcidm cytlvrncps dfqfscpndl ttedllyqsy nfymdtdyst cnyignsslm 541 vihplddt // LOCUS NP_014109 340 aa linear PLN 30-JUN-2025 DEFINITION replication factor C subunit 3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014109 VERSION NP_014109.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183128.1 REFERENCE 1 (residues 1 to 340) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 340) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 340) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 340) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 340) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10269. Method: conceptual translation. FEATURES Location/Qualifiers source 1..340 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..340 /product="replication factor C subunit 3" /calculated_mol_wt="38073" Region 11..324 /region_name="rfc" /note="replication factor C small subunit; Reviewed; PRK00440" /db_xref="CDD:234763" CDS 1..340 /gene="RFC3" /locus_tag="YNL290W" /coded_by="NM_001183128.1:1..1023" /experiment="EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:8995429|PMID:12604797]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005663 DNA replication factor C complex [PMID:7651383]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006272 leading strand elongation [PMID:1346062]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:8302859]" /experiment="EXISTENCE:direct assay:GO:0031389 Rad17 RFC-like complex [PMID:12604797|PMID:10660302]" /experiment="EXISTENCE:physical interaction:GO:0031389 Rad17 RFC-like complex [PMID:10660302]" /experiment="EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]" /experiment="EXISTENCE:physical interaction:GO:0031391 Elg1 RFC-like complex [PMID:12912927]" /note="Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:855426" /db_xref="SGD:S000005234" ORIGIN 1 mststekrsk enlpwvekyr petldevygq nevittvrkf vdegklphll fygppgtgkt 61 stivalarei ygknysnmvl elnasddrgi dvvrnqikdf astrqifskg fkliildead 121 amtnaaqnal rrvierytkn trfcvlanya hkltpallsr ctrfrfqplp qeaierrian 181 vlvheklkls pnaekaliel sngdmrrvln vlqsckatld npdedeisdd viyeccgapr 241 psdlkavlks ileddwgtah ytlnkvrsak glalidlieg ivkiledyel qneetrvhll 301 tkladieysi skggndqiqg savigaikas fenetvkanv // LOCUS NP_014110 279 aa linear PLN 30-JUN-2025 DEFINITION Pcl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014110 VERSION NP_014110.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183127.1 REFERENCE 1 (residues 1 to 279) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 279) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 279) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 279) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 279) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10270. Method: conceptual translation. FEATURES Location/Qualifiers source 1..279 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..279 /product="Pcl1p" /calculated_mol_wt="31964" Region 54..149 /region_name="CYCLIN_ScPCL1-like" /note="cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; cd20557" /db_xref="CDD:410260" Site order(71,111,119..121,137,140..141) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410260" CDS 1..279 /gene="PCL1" /locus_tag="YNL289W" /gene_synonym="HCS26" /coded_by="NM_001183127.1:1..840" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:14688790]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14688790]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7973730]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:19458192]" /experiment="EXISTENCE:genetic interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:20417603]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:7973730]" /experiment="EXISTENCE:physical interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]" /note="Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth" /db_xref="GeneID:855427" /db_xref="SGD:S000005233" ORIGIN 1 mceyskalhi llkspvtddi ikfltdttlr vvpssnyptp pgspgekhlt rlpslmtfit 61 rlvrytnvyt ptlltaacyl nklkrilprd atglpstihr iflaclilsa kfhndsspln 121 khwarytdgl ftledinlme rqllqllnwd lrvntedlil dlqpllepik qdlarssdqr 181 krinmmmsmn rrtcagtspi rsnnrfklye kqrnvsiasd lssatlvdsc ndlrrlkdvt 241 nianntvant nyvrtvekwn dnvnrqswdl eqimsqhgf // LOCUS NP_014111 373 aa linear PLN 30-JUN-2025 DEFINITION CCR4-NOT core subunit CAF40 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014111 VERSION NP_014111.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183126.1 REFERENCE 1 (residues 1 to 373) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 373) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 373) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 373) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10271. Method: conceptual translation. FEATURES Location/Qualifiers source 1..373 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..373 /product="CCR4-NOT core subunit CAF40" /calculated_mol_wt="41024" Region 30..373 /region_name="RCD1" /note="Uncharacterized protein involved in cell differentiation/sexual development [General function prediction only]; COG5209" /db_xref="CDD:227534" CDS 1..373 /gene="CAF40" /locus_tag="YNL288W" /coded_by="NM_001183126.1:1..1122" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:11733989]" /note="Component of the CCR4-NOT transcriptional complex; evolutionarily conserved; involved in controlling mRNA initiation, elongation, and degradation; binds Cdc39p" /db_xref="GeneID:855428" /db_xref="SGD:S000005232" ORIGIN 1 mfsaqkpiyg ngagvnmggg gpstnnpgsm smpgvptsmg pgmnqqipsg gpmlmgntpn 61 nnnsnengen ngnngnnggn danatrnnpn mvnnrgavha lddpnvyhwi cqltygpqke 121 qallelgrkr eqfddlavvl wssfgvmtsl lneiisvypm lqpqmlsnnl snrvcnalvl 181 lqcvashpet khlflqahip lflfpflntt srqrtfeylr ltslgvigal vkndsqdvit 241 fllrtdivpl clrimessse lsktvaifil qkillddvgl qyicatlerf yavtnvlkdm 301 vehltvstpp grllkhiirc ylrlsddlea rrllkivlpa klrdntftev lrddvgskrc 361 laqllltlne ets // LOCUS NP_014112 935 aa linear PLN 30-JUN-2025 DEFINITION coatomer subunit gamma [Saccharomyces cerevisiae S288C]. ACCESSION NP_014112 VERSION NP_014112.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183125.1 REFERENCE 1 (residues 1 to 935) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 935) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 935) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 935) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 935) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 935) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 935) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 935) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10272. Method: conceptual translation. FEATURES Location/Qualifiers source 1..935 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..935 /product="coatomer subunit gamma" /calculated_mol_wt="104700" Region 1..935 /region_name="SEC21" /note="Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]; COG5240" /db_xref="CDD:227565" Site order(281,285,289,323,327,331,360,364) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293788" Region 298..334 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 379..403 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 416..442 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(434..435,438,441..442,469..470,473,476..477,480, 508..509,512,515..516,519,547..548,551,554..555) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 454..480 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 490..520 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 529..555 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..935 /gene="SEC21" /locus_tag="YNL287W" /coded_by="NM_001183125.1:1..2808" /experiment="EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:1461285]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:1461285]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8001155]" /note="Gamma subunit of coatomer; coatomer is a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo" /db_xref="GeneID:855429" /db_xref="SGD:S000005231" ORIGIN 1 msahtykkfe nstsgdlpdk mtiyqdcmnt fnespvnskr crllisrllr llaqgetfpq 61 neatalffsi sklfqhqndp lrqavylaik elsgisedvl matssimkdv qngsdlikpd 121 airsltyvld estafsaerl lksavvsrhp sissaalcts yhllpisevt irrftnetqe 181 avldlkqfpn qhgnseyypn styisqyhal gllyqlkktd kmallklvrh fsennsmknq 241 lakvelvkiv ndliyrdpql fsqfrpllsd wlsnkfesvq letaklitsf atrnsrlvap 301 elyaaaisal qslltvprvs srfaalriln rismvspeki vvcnpelesl indsnrnist 361 yaittllktg tsknisslis titnfihdvs ddfkiiiida vrtlslnfpq ewksilnfli 421 dvlknseggf kfknsiveal idivsfvpqs kelalenlcd fiedcefnei lvrilhllgk 481 egpsapnpsl yvrhiynrvv lensiirsaa vvalskfalt kndptlyesi isllkriand 541 kddevrdrat ialefidsar nkddviaqnl ieskyfydip slesklssyi ssntdsfata 601 fdvnqvrkft edemkainlk rkqeqifnqk settldttpe aesvpekrad ansfagpnld 661 dhqedllatk yadellsieq ikpfgqlvns sraisltepe aefvvrgvkh lfkdnvvlqf 721 nitntltdia ldnvsvvctp eisdeaelee lftlqvdrll pseeaacyva fkkldeivme 781 gflnnltftt keinpdtnep fdgdegfqde yeidsiflna gdyvkssftg nfsatfdelp 841 ceevavfniq edlsiqevvd kiilnssclp vestqfapsd snshtlklfg ksaltgskva 901 lqikmikssk glalkvhgkg edsllcsdlv nglmq // LOCUS NP_014113 285 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit CUS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014113 VERSION NP_014113.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183124.1 REFERENCE 1 (residues 1 to 285) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 285) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 285) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 285) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10273. Method: conceptual translation. FEATURES Location/Qualifiers source 1..285 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..285 /product="U2 snRNP complex subunit CUS2" /calculated_mol_wt="32153" Region 44..134 /region_name="RRM1_TatSF1_like" /note="RNA recognition motif 1 (RRM1) found in HIV Tat-specific factor 1 (Tat-SF1) and similar proteins; cd12281" /db_xref="CDD:409723" Region 182..262 /region_name="RRM3_RBM39_like" /note="RNA recognition motif 3 (RRM3) found in vertebrate RNA-binding protein 39 (RBM39) and similar proteins; cd12285" /db_xref="CDD:409727" CDS 1..285 /gene="CUS2" /locus_tag="YNL286W" /coded_by="NM_001183124.1:1..858" /experiment="EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:26631165]" /experiment="EXISTENCE:direct assay:GO:0034337 RNA folding [PMID:26631165]" /experiment="EXISTENCE:genetic interaction:GO:1903241 U2-type prespliceosome assembly [PMID:9710584]" /experiment="EXISTENCE:mutant phenotype:GO:0030620 U2 snRNA binding [PMID:26631165|PMID:9710584]" /experiment="EXISTENCE:mutant phenotype:GO:0034337 RNA folding [PMID:26631165]" /experiment="EXISTENCE:physical interaction:GO:0005686 U2 snRNP [PMID:26631165]" /experiment="EXISTENCE:physical interaction:GO:1903241 U2-type prespliceosome assembly [PMID:9710584]" /note="Putative checkpoint factor in transcription; binds to U2 snRNA and Prp11p; regulates toggling of the U2 snRNA stem II region between different structures; contains two RNA recognition motifs (RRMs)" /db_xref="GeneID:855430" /db_xref="SGD:S000005230" ORIGIN 1 mdadelelkg hlkklkkeel lrrkqlkesn lqkreleynn askntsiyis glptdkttke 61 glteqfckyg mirtnrdgep lcklyvndkg afkgdality skeesvtlai emmnesiflg 121 kqirveraqf qnkegdnmhg kendlkefng peppikrlkk aksegegevi dynddeslak 181 adrtvifanv fniyksytnd dindiqedll egceeigqvd sisvspnkge atvvfknnkv 241 alqcckimtg ryfdgqklla fisgdentss tsdknedsev eddli // LOCUS NP_058178 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058178 VERSION NP_058178.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184415.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10274. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198868" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region <907..1163 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YNL284C-B" /coded_by="join(NM_001184415.2:1..1305, NM_001184415.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:855433" /db_xref="SGD:S000007387" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqtaqshsp qngpyqqqcm mtqnqanpsg wsfygrpsmi pytpyqmspm 121 yfppgphsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 flnwvktyik flqnsnlgdi iptatrkavr qmtddeltfl chtfqlfaps qflptwvkdi 241 lsadytdimk ilsksinkmq sdtqevndit tlatlhyngs tpadafeaev tnildrlnnn 301 gipinnkvac qfimrglsge ykflryarhr yihmtvadlf sdihsmyeeq qeskrnksty 361 rrnpsdekkd srtytnttkp ksitrnsqkp nnsqsrtara hnvstsnnss gpdndlirgs 421 ttepiqlknk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npginvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsd dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisksnilps kkrsstpqis diestgsggm 1021 hrldvpllap msqynthess htskskdfrh sdsysdnetn htnvpisstg gtnnktvpqt 1081 seqetekrii hrspsidtss sesnslhhvv piktsdtcpk enteesiiad lplpdlppep 1141 ptklsdsfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd ryydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli qqcgmeevrg wscvfknsqv ticlfvddmv lfsknlnsnk 1441 riieklkmqy dtkiinlges deeiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqq eleleeddyk mkvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsk qvldmtyeli qfiwntrdkq liwhkskpvk ptnklvvisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qeldkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_058179 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058179 VERSION NP_058179.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184414.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10275. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..440 /product="gag protein" /calculated_mol_wt="49178" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YNL284C-A" /coded_by="NM_001184414.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:855434" /db_xref="SGD:S000007386" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqtaqshsp qngpyqqqcm mtqnqanpsg wsfygrpsmi pytpyqmspm 121 yfppgphsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 flnwvktyik flqnsnlgdi iptatrkavr qmtddeltfl chtfqlfaps qflptwvkdi 241 lsadytdimk ilsksinkmq sdtqevndit tlatlhyngs tpadafeaev tnildrlnnn 301 gipinnkvac qfimrglsge ykflryarhr yihmtvadlf sdihsmyeeq qeskrnksty 361 rrnpsdekkd srtytnttkp ksitrnsqkp nnsqsrtara hnvstsnnss gpdndlirgs 421 ttepiqlknk hdlhlrpgty // LOCUS NP_014115 322 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL15m MRPL10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014115 VERSION NP_014115.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183122.1 REFERENCE 1 (residues 1 to 322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 322) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10276. Method: conceptual translation. FEATURES Location/Qualifiers source 1..322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..322 /product="mitochondrial 54S ribosomal protein uL15m MRPL10" /calculated_mol_wt="36216" Region 60..211 /region_name="rplO_bact" /note="ribosomal protein L15, bacterial/organelle; TIGR01071" /db_xref="CDD:273428" CDS 1..322 /gene="MRPL10" /locus_tag="YNL284C" /gene_synonym="MRPL18; uL15m" /coded_by="NM_001183122.1:1..969" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels" /db_xref="GeneID:855436" /db_xref="SGD:S000005228" ORIGIN 1 mkaerqtglr nsfttvigrk lintfvpsmm ltsvagndif frglfkspvl afqsyryvsi 61 lgqlkpsdgs tksfkrlgrg pssglgktsg rgqkgqkarg kvkswfeggq tpiyklfpki 121 gftnvgakpl kelnlkriqw fhdknrlhlq pgevldmnkm rklglvtgpi kygvkilasg 181 kfhynlpial easrasakai aaiekaggkf taryytplgl rahlnpqwfl ekrgrvplqa 241 rptkrrdidf yskeekrgyl vmekdkllqd ikeaqnkgsr hflkqnvkks sleieleels 301 pekdwvpvvs nskvmnikal dh // LOCUS NP_014116 503 aa linear PLN 30-JUN-2025 DEFINITION Wsc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014116 VERSION NP_014116.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183121.1 REFERENCE 1 (residues 1 to 503) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 503) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 503) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 503) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10277. Method: conceptual translation. FEATURES Location/Qualifiers source 1..503 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..503 /product="Wsc2p" /calculated_mol_wt="52162" Region 25..118 /region_name="WSC" /note="present in yeast cell wall integrity and stress response component proteins; smart00321" /db_xref="CDD:214616" CDS 1..503 /gene="WSC2" /locus_tag="YNL283C" /gene_synonym="STA3" /coded_by="NM_001183121.1:1..1512" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27337501|PMID:20652590]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:20652590|PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:20652590]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:11545731]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:mutant phenotype:GO:0004888 transmembrane signaling receptor activity [PMID:10430578]" /experiment="EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:10348843]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10348843]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10348843]" /note="Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication" /db_xref="GeneID:855438" /db_xref="SGD:S000005227" ORIGIN 1 mhldlihksf ilvwliyira aladqftyka cysasdirkl gltykgvyey qsvsycqnec 61 pgqavvalfn gtgcycggsv aqlqsltqvd sskcdvscag wpyqncggss amnvyinnaa 121 stadstssta tststtssss tsvssktstk ldtktstsss athsssssst tstttssset 181 ttssssssss sststtstts ttssttstss spsttsssts assssetsst qatsssttst 241 ssststatvt stpsstsigt sthyttrvvt qsvvsqanqq astifttrts vyatvsstss 301 stssllngks ssskskglsg gaiagvvvgv vcgtvallal alfffvwkkr rqssqhvdle 361 etkqyqpysl gdadanpvip psasstnwhi psrnntalsk ntastfatyd lptrapggrd 421 siitgdahni skrshfpsvv yeeppsiyng nqrfsatslp dmmeerqlhi vnpdnvssni 481 gsnvsdgddd yddakdsnns slr // LOCUS NP_014117 195 aa linear PLN 30-JUN-2025 DEFINITION Pop3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014117 VERSION NP_014117.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183120.1 REFERENCE 1 (residues 1 to 195) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 195) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 195) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 195) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10278. Method: conceptual translation. FEATURES Location/Qualifiers source 1..195 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..195 /product="Pop3p" /calculated_mol_wt="22481" Region 14..171 /region_name="RNase_P_pop3" /note="RNase P subunit Pop3; pfam08228" /db_xref="CDD:400504" CDS 1..195 /gene="POP3" /locus_tag="YNL282W" /coded_by="NM_001183120.1:1..588" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:9029160]" /experiment="EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:9029160]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9029160]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:9029160]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380|PMID:9029160]" /experiment="EXISTENCE:physical interaction:GO:0005655 nucleolar ribonuclease P complex [PMID:9029160]" /note="Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; increases the activity and thermal stability of the RNase P complex, along with Pop2p; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:855439" /db_xref="SGD:S000005226" ORIGIN 1 msgslksldk kiakrrqvyk pvldnpftne ahmwprvhdq pliwqllqss iinklihiqs 61 kenypwelyt dfneivqyls gahgnsdpvc lfvcnkdpdv plvllqqipl lcymapmtvk 121 lvqlpksamd tfksvskygm lllrcddrvd kkfvsqiqkn vdllqfpwln aikyrptsvk 181 llkttvpivs kkrqk // LOCUS NP_014118 153 aa linear PLN 30-JUN-2025 DEFINITION Hch1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014118 VERSION NP_014118.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183119.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10279. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..153 /product="Hch1p" /calculated_mol_wt="17115" Region 13..146 /region_name="Aha1_N" /note="Activator of Hsp90 ATPase, N-terminal; smart01000" /db_xref="CDD:214964" CDS 1..153 /gene="HCH1" /locus_tag="YNL281W" /coded_by="NM_001183119.1:1..462" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:12504007]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:12504007]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:12504007]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:12504007]" /note="Heat shock protein regulator; binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; role in regulating Hsp90 inhibitor drug sensitivity; GFP-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855440" /db_xref="SGD:S000005225" ORIGIN 1 mvvlnpnnwh wvdkntlpws kdylngklts lstvssdgks kieltqvssi tgdsnvsqrk 61 gkpicyfdlq lsmnvkvtnl dtnkddeddd giladgklei pefmhdesdi pilsqgfdaf 121 dglvrsefvp kvvetllkyq ddlikehskd iqv // LOCUS NP_014119 438 aa linear PLN 30-JUN-2025 DEFINITION delta(14)-sterol reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014119 VERSION NP_014119.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183118.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10280. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..438 /product="delta(14)-sterol reductase" /EC_number="1.3.1.70" /calculated_mol_wt="50485" Region 8..438 /region_name="ERG4_ERG24" /note="Ergosterol biosynthesis ERG4/ERG24 family; pfam01222" /db_xref="CDD:250456" CDS 1..438 /gene="ERG24" /locus_tag="YNL280C" /coded_by="NM_001183118.1:1..1317" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0050613 Delta14-sterol reductase activity [PMID:32908]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:8125337|PMID:1394506|PMID:1418625]" /experiment="EXISTENCE:mutant phenotype:GO:0050613 Delta14-sterol reductase activity [PMID:8125337|PMID:1394506]" /note="C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions" /db_xref="GeneID:855441" /db_xref="SGD:S000005224" ORIGIN 1 mvsalnprtt efefggliga lgisiglpvf tiilnqmirp dyfikgffqn fdivelwngi 61 kplryylgnr elwtvyclwy gilavldvil pgrvmkgvql rdgsklsyki ngiamsttlv 121 lvlairwklt dgqlpelqyl yenhvslcii silfsfflat ycyvasfipl ifkkngngkr 181 ekilalggns gniiydwfig relnprlgpl dikmfselrp gmllwllinl sclhhhylkt 241 gkindalvlv nflqgfyifd gvlneegvlt mmdittdgfg fmlafgdlsl vpftyslqar 301 ylsvspvelg wvkvvgilai mflgfhifhs ankqksefrq gklenlksiq tkrgtkllcd 361 gwwaksqhin yfgdwlisls wclatwfqtp ltyyyslyfa tlllhrqqrd ehkcrlkyge 421 nweeyerkvp ykiipyvy // LOCUS NP_014120 661 aa linear PLN 30-JUN-2025 DEFINITION pheromone-regulated protein PRM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014120 VERSION NP_014120.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183117.1 REFERENCE 1 (residues 1 to 661) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 661) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 661) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 661) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10281. Method: conceptual translation. FEATURES Location/Qualifiers source 1..661 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..661 /product="pheromone-regulated protein PRM1" /calculated_mol_wt="73222" CDS 1..661 /gene="PRM1" /locus_tag="YNL279W" /coded_by="NM_001183117.1:1..1986" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:11062271]" /experiment="EXISTENCE:mutant phenotype:GO:0032220 plasma membrane fusion involved in cytogamy [PMID:11062271|PMID:15590839]" /note="Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p" /db_xref="GeneID:855442" /db_xref="SGD:S000005223" ORIGIN 1 msgfkcylql gdrlsqiwln kytlvlllam lkllffsksi qhaievsety ilsncysids 61 lyskmtdntp hylgimgnyl iekgmeetvk atletlsliv yaseglvnfa idlylgtyac 121 livsavdgtv dvatnitekl islvndtvss vaneldtgln diskiinkvi kaaskvenff 181 tgddddsnmt ssiksvnlti salhnlyips sindkleels aktpdfaqvk nttknlisvp 241 fnevrknika vnasniigdt svlyvppvsl dnstgicssn qseilafysi lghvlkiatv 301 vcitvlicfa vgamapvawn eiklwrrlcg mrdhymlsrq dsytsfssen thelkdpfrd 361 ppiqngqydv iasyqqcfqt wntriagwmt nlvtfgkspe nidpktkqki ewvvaymtse 421 ralcvlgigl lgilvcicqf vmiallkhki shsltsndgd gvqnllksst avdienqmsl 481 wsvqtnkyin ttetninqev fgwintttls vnntvatmis didttladvf ngtllynpmk 541 tvvgcaienk lytiekamtw ihdkaqlhip ringtqikqa lakqtdnsti ptasstsaat 601 enllenlvnd mregllkilr ayhritlgel tvalvilavw lvqlpialvi lrlrlrkatf 661 d // LOCUS NP_014121 1060 aa linear PLN 30-JUN-2025 DEFINITION Caf120p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014121 VERSION NP_014121.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183116.1 REFERENCE 1 (residues 1 to 1060) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1060) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1060) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1060) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1060) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1060) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1060) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1060) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10282. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1060 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1060 /product="Caf120p" /calculated_mol_wt="118149" Region 88..204 /region_name="PH" /note="PH domain; pfam00169" /db_xref="CDD:459697" Region <808..1039 /region_name="PHA03247" /note="large tegument protein UL36; Provisional" /db_xref="CDD:223021" CDS 1..1060 /gene="CAF120" /locus_tag="YNL278W" /coded_by="NM_001183116.1:1..3183" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:25028499]" /note="Part of the CCR4-NOT transcriptional regulatory complex; involved in controlling mRNA initiation, elongation, and degradation; contains a PH-like domain; CAF120 has a paralog, SKG3, that arose from the whole genome duplication" /db_xref="GeneID:855443" /db_xref="SGD:S000005222" ORIGIN 1 mrifsgdnkv vdslasnpgl mspsnfggdf gsrlkvnvts kkklndsspt spmesspvsp 61 elvpiltlln ahthrryheg vflilqdlnn ngthaarkwk dvygvllgtq lalwdakela 121 eftdpscpvs ekklkevask ptyinltdat lrtldnsdni vmecgknltn alvvsttlkn 181 ryflqfgnke sfnawnsair lclyecsslq eaytgafiss rgaklgdiri lltnrkydyk 241 dwvsvrfgag mpwkrcyavi sqssskkkgh fgeinlyend kkvkknhama tiveakalya 301 vypsspklid sstiikvvgs vkfekkesaq ekdvfimpek hqavpsydti irflipamdt 361 fklygrpekl lsskndphsl lfglpvlphi yylevedllp ltnsvsslhw snnewkehis 421 dilqrkiaqg ycgcnstsni tsplpspflg sadlferadg vlspklsygs ksssnnsskn 481 slpkrervkl sssseqdlnn sdspsikrks pplvisesph kvhtptdasf rtrvtegspy 541 akqrhpkpfa ssvndspsdr aksrtvpynn ndrkattpek fergetscgk nvdeslekvr 601 nmkleipesn fdkfmtdknl lsvdskcsne kklsvesdls aiyekysngp fghteglngs 661 sdetylrfqr asvhsesnyn srksftpsdf sngneeehav lqelnsltqr inelgmesin 721 snsdsdring sysqvdfgnn ndeddmnlfd pdfmaqdqlr aeerdynkdd rtplakvpaa 781 fqstglgitp dddierqyit ehrsrhevpk rspekpsnpl eignpyakpg trlntthths 841 ktdrsitpqr gqpvpsgqqi ssyvqpanin spnkmygann samgsprnpk trappgpynq 901 gwnnrpspsn iyqrphpsdt qpqayhlpgn pystgnrpnm qaqyhpqqvp mpilqqpnrp 961 yqpyamnthm gspggyagaa ppfqpanvny ntrpqqpwpt pnspsahyrp ppnlnqpqng 1021 sagyyrppap qlqnsqarpq kkdgfsqfmp sattknpyaq // LOCUS NP_878151 62 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL277W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878151 VERSION NP_878151.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184664.1 REFERENCE 1 (residues 1 to 62) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 62) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 62) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 62) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10283. Method: conceptual translation. FEATURES Location/Qualifiers source 1..62 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..62 /product="uncharacterized protein" /calculated_mol_wt="7077" CDS 1..62 /locus_tag="YNL277W-A" /coded_by="NM_001184664.1:1..189" /note="hypothetical protein" /db_xref="GeneID:1466509" /db_xref="SGD:S000028852" ORIGIN 1 mtlayygqpv kmchilpplr slpvlvgkkk lkkkksqttn nhviflftlf ikllkthnrm 61 sl // LOCUS NP_014122 486 aa linear PLN 30-JUN-2025 DEFINITION homoserine O-acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014122 VERSION NP_014122.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183115.1 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10284. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..486 /product="homoserine O-acetyltransferase" /EC_number="2.3.1.31" /calculated_mol_wt="53529" Region 35..449 /region_name="homoserO_Ac_trn" /note="homoserine O-acetyltransferase; TIGR01392" /db_xref="CDD:273596" CDS 1..486 /gene="MET2" /locus_tag="YNL277W" /coded_by="NM_001183115.1:1..1461" /experiment="EXISTENCE:direct assay:GO:0004414 homoserine O-acetyltransferase activity [PMID:3301801]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0009092 homoserine metabolic process [PMID:3301801]" /experiment="EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:1101032]" /experiment="EXISTENCE:mutant phenotype:GO:0004414 homoserine O-acetyltransferase activity [PMID:3301801]" /experiment="EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:6035500]" /experiment="EXISTENCE:mutant phenotype:GO:0009092 homoserine metabolic process [PMID:3301801]" /note="L-homoserine-O-acetyltransferase; catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway" /db_xref="GeneID:855444" /db_xref="SGD:S000005221" ORIGIN 1 mshtlksktl qeldieeike tnpllklvqg qrivqvpelv lesgvvinnf piayktwgtl 61 neagdnvlvi chaltgsadv adwwgpllgn dlafdpsrff iiclnsmgsp ygsfspltin 121 eetgvrygpe fplctvrddv rahrivldsl gvksiacvig gsmggmlsle waamygkeyv 181 knmvalatsa rhsawcisws eaqrqsiysd pnyldgyypv eeqpvaglsa armsalltyr 241 trnsfenkfs rrspsiaqqq kaqreetrkp stvsehslqi hndgyktkas taiagisgqk 301 gqsvvstass sdslnsstsm tsvssvtgev kdikpaqtyf saqsylryqg tkfinrfdan 361 cyiaitrkld thdlardrvd ditevlstiq qpsliigiqs dglftyseqe flaehipksq 421 lekiespegh dafllefkli nklivqflkt nckaitdaap rawggdvgnd etktsvfgea 481 eevtnw // LOCUS NP_014124 576 aa linear PLN 30-JUN-2025 DEFINITION Bor1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014124 VERSION NP_014124.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183113.1 REFERENCE 1 (residues 1 to 576) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 576) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 576) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 576) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10285. Method: conceptual translation. FEATURES Location/Qualifiers source 1..576 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..576 /product="Bor1p" /calculated_mol_wt="64897" Region 61..475 /region_name="HCO3_cotransp" /note="HCO3- transporter family; cl46638" /db_xref="CDD:480978" CDS 1..576 /gene="BOR1" /locus_tag="YNL275W" /coded_by="NM_001183113.1:1..1731" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16565073]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12447444|PMID:11401825]" /experiment="EXISTENCE:direct assay:GO:0046713 borate transport [PMID:17459946]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0080139 borate efflux transmembrane transporter activity [PMID:17459946]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:16565073]" /experiment="EXISTENCE:mutant phenotype:GO:0046713 borate transport [PMID:17459946|PMID:16923078|PMID:12447444]" /experiment="EXISTENCE:mutant phenotype:GO:0080139 borate efflux transmembrane transporter activity [PMID:12447444|PMID:17459946|PMID:16923078]" /note="Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1; human ortholog SLC4A5 is key biomarker and therapeutic target for Niemann-Pick type C (NPC) disease" /db_xref="GeneID:855446" /db_xref="SGD:S000005219" ORIGIN 1 msnestrvtv srgctasdec aqalertnde ldressvses rsdeeshekl srrrfptlgi 61 giwldlkdri pyyksdwvda fnyrvipsiv dtyfnnllpa iafaqdmfdr tdnsygvnev 121 llssamagiv fgvlggqplc ivgvtgpisi fnytvyeiik plntsyfgfm fwicmwsmif 181 hlvlaftnav cllqyvttfp cdifglfinv vyiqkgiqil trqfsaksge ksvqdgfasv 241 vvalvmtafg lffklfhyyp lfshrirtfi sdystalsvl fwssfthfgg ylhdvkfkkl 301 pitkaffpts kvnrpqntwl ayepipvkdv fialpfgifl tilfyfdhnv sslmaqrhqy 361 klkkpssfhy dfallglttc isgvlgipap nglipqaplh tetllvrdsn qkviscveqr 421 ftntfqglmi lgtmtrpllv clgeipqavl sglffimgin glmtnsiiqr lvflfsdpnr 481 rdntsplmkv skksmlifls fsltgfagef aitntiaaig fplvlllsvl vsfsfayifp 541 teelkildtn vaqkftiknl llenirdakf cdkhed // LOCUS NP_014125 350 aa linear PLN 30-JUN-2025 DEFINITION glyoxylate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014125 VERSION NP_014125.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183112.1 REFERENCE 1 (residues 1 to 350) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 350) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 350) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 350) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10286. Method: conceptual translation. FEATURES Location/Qualifiers source 1..350 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..350 /product="glyoxylate reductase" /EC_number="1.1.1.26" /EC_number="1.1.1.79" /EC_number="1.1.1.81" /calculated_mol_wt="38700" Region 4..329 /region_name="Mand_dh_like" /note="D-Mandelate Dehydrogenase-like dehydrogenases; cd12168" /db_xref="CDD:240645" Site order(62,90..92,115,254,301) /site_type="other" /note="putative ligand binding site [chemical binding]" /db_xref="CDD:240645" Site order(117..118,121,125,128..129,132,134..135,144,146, 149..150,153,159..162,164,180..181,184..185,280,283..285, 291,293,296..303,306..308,310) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:240645" Site order(119,171..174,194..195,224..228,231,252..254,278,301, 303..304) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:240645" CDS 1..350 /gene="GOR1" /locus_tag="YNL274C" /coded_by="NM_001183112.1:1..1053" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0009436 glyoxylate catabolic process [PMID:17173333]" /experiment="EXISTENCE:mutant phenotype:GO:0047964 glyoxylate reductase (NADH) activity [PMID:17173333]" /note="Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855447" /db_xref="SGD:S000005218" ORIGIN 1 mskkpivlkl gkdafgdqaw gelekiadvi tipesttreq flrevkdpqn klsqvqvitr 61 tarsvkntgr fdeelalalp ssvvavchtg agydqidvep fkkrhiqvan vpdlvsnata 121 dthvflllga lrnfgignrr liegnwpeag pacgspfgyd pegktvgilg lgrigrcile 181 rlkpfgfenf iyhnrhqlps eeehgceyvg feeflkrsdi vsvnvplnhn thhlinaeti 241 ekmkdgvviv ntargavide qamtdalrsg kirsagldvf eyepkiskel lsmsqvlglp 301 hmgthsvetr kkmeelvven aknviltgkv ltivpelqne dwpneskplv // LOCUS NP_014126 1238 aa linear PLN 30-JUN-2025 DEFINITION Tof1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014126 VERSION NP_014126.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183111.1 REFERENCE 1 (residues 1 to 1238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1238) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10287. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1238 /product="Tof1p" /calculated_mol_wt="140990" Region 44..366 /region_name="TIMELESS" /note="Timeless protein; pfam04821" /db_xref="CDD:461444" CDS 1..1238 /gene="TOF1" /locus_tag="YNL273W" /coded_by="NM_001183111.1:1..3717" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0031298 replication fork protection complex [PMID:19819872]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:16219777]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:17483413|PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0000076 DNA replication checkpoint signaling [PMID:12944972]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:16137625]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:16219777]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:17483413|PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0031297 replication fork processing [PMID:18632578]" /experiment="EXISTENCE:mutant phenotype:GO:0043111 replication fork arrest [PMID:16418273|PMID:17652453|PMID:16103218]" /experiment="EXISTENCE:mutant phenotype:GO:0043570 maintenance of DNA repeat elements [PMID:18321795]" /note="Subunit of a replication-pausing checkpoint complex; the replication fork protection complex (Tof1p-Mrc1p-Csm3p) acts at stalled forks and is required for rapid replication fork progression, replisome stabilization under stress, mediating checkpoint signaling and promoting sister chromatid cohesion after damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; recruits Top1p to the fork to suppress DNA damage; relocalizes to the cytosol in response to hypoxia to hypoxia" /db_xref="GeneID:855448" /db_xref="SGD:S000005217" ORIGIN 1 msadlqqgtt naadfsltvl rariallata iggpdytsqi dpppyklgdd claclkdlkr 61 wfklvddqqk rwdvamavae yriltddllp ilidwenkcs laaklaknnp dheefrnkay 121 ydkialnclq llvlmtwpli vteqsssnqi tlygelkkhq lvykktilsm esgkvlraai 181 rlaldvikid rlsrtprdnm vlklvlnffr nviaiepgef tintkksmpk kgitsidtlp 241 pnvsmddisl ntvissfhkn kvfgflltlt sslskefdqd finiplleim fyftkdvnqe 301 llfprqfetg thskvvnkne sssannivts agfelskllq kehqmrknvi khtsarhsrf 361 ggllsiqtpd ktrltvsgsq alvdekialq klddskkwnk riikkhqsva aeglpnslln 421 sqtgkaifft esngkhfkef innfidsgfn illhsvtnyf tteqdrmvtl eqveyllffa 481 wfvkyqllrs kidnsadikq vsealkevtf ilvssllrsa ydlknwtvth agmiafnell 541 nlvsrtkaaq eedstdiefi vsrlfsderi qllsnlpkig skyslqfmks cielthsvlk 601 vleqysddkt lviegksrrq kkfnisegdi tklieeenvd rdealdilts slrsievnfq 661 kvqanymtep vietyinfle rfreleddsi kkvfsffhrv fvqakeqall frfdliillr 721 emlspdgldr msrsrkyvsq fsdyflarlk krlkkspawf vgllfpplhn sevgfyqryg 781 eynvlnnesm yaapasqfkp ipdeealpps illdmkygvl vstllddgkt elldqllkhi 841 thtldifksw ltvnvnagke tvnppneyft ltgvlnndpi fkdkdyrall lligysiprk 901 inepcflpgt vevsdltvsc elvkkylstp fetpnglpss syllrvrsek dsfshneqdg 961 wegdddydyn dpyivpddqi lsksdaayfk dldnnasdkl kgtkfskgia rskkkdkrkr 1021 rkgeaktnlp mfgdqdderp qtvrerhgvf skefisdsed dedlmnpiff enetymrwll 1081 dknngqlted ryiqfakfaa ermnnggvvt gdytslfggs ipsiesirat esssfapdks 1141 lislashvas emsifdvnnn nnnqlsdddv nsesrnslgs sqpsnsqnmf qsevysrkes 1201 tkrsleasaa desdedeeai rlfgkksrvv lsqgdsdd // LOCUS NP_014127 759 aa linear PLN 30-JUN-2025 DEFINITION guanine nucleotide exchange factor SEC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014127 VERSION NP_014127.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183110.1 REFERENCE 1 (residues 1 to 759) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 759) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 759) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 759) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10288. Method: conceptual translation. FEATURES Location/Qualifiers source 1..759 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..759 /product="guanine nucleotide exchange factor SEC2" /calculated_mol_wt="84521" Region <4..>139 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 79..170 /region_name="Sec2p" /note="GDP/GTP exchange factor Sec2p; pfam06428" /db_xref="CDD:428938" Region 216..399 /region_name="Rab11BD_RAB3IP_like" /note="Rab11 binding domain of Rab-3A-interacting protein (RAB3IP), Rab-3A-interacting-like protein 1 (RAB3IL1) and similar proteins; cd21044" /db_xref="CDD:411031" Site order(285..290,381,384..385,388,392,397..399) /site_type="other" /note="Rab11 binding site [polypeptide binding]" /db_xref="CDD:411031" CDS 1..759 /gene="SEC2" /locus_tag="YNL272C" /coded_by="NM_001183110.1:1..2280" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9199166]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12045183]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:20493815]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:20493815]" /experiment="EXISTENCE:direct assay:GO:0030133 transport vesicle [PMID:12045183]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:20493815]" /experiment="EXISTENCE:genetic interaction:GO:0006914 autophagy [PMID:20444978]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:12045183]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:20444978]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:29293994]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:29293994]" /experiment="EXISTENCE:mutant phenotype:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:20493815]" /note="Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles" /db_xref="GeneID:855449" /db_xref="SGD:S000005216" ORIGIN 1 mdaseeakrv siqvtslstq liesvdkqsh leeqlnkslk tiasqkaaie nynqlkedyn 61 tlkrelsdrd devkrlredi akenelrtka eeeadklnke vedltaslfd eannmvadar 121 kekyaieiln krlteqlrek dtlldtltlq lknlkkvmhs ldnestvtnn snrystilsd 181 satssstsln kvptsyslas qdiysgivys psissirydi slyneflkfv aalprcenik 241 atstesklir rlvndeiqpi lkidnasgig wlvkktllsl iidglvvvep lsgvnatyqi 301 gynssspakq atsnmpkmfk fpldsppvav haacsfcges rddiieharm yilktlhktd 361 dgkeqvtnty plchwcllkl rqtceifafl rslkvgawhl eklttqnitk edlekfsevt 421 khtkrdgrvs sqdkktkrls fmaglginss tknkpkmeif ssetnakpgq pttniqrawl 481 qlcklrcilh wthigiwavd dsisskigpl veddsdedqn daisvrlqdk alwkqdakrp 541 fssssaeesq ksdafdfesg dmeneitges ssdesssdgs stdnstadss sedesslads 601 ttssadsssp esidngegdd tvtkddkssi ksannneens dcgdkkgrsi ikkkapqrki 661 qkkkllqdld dleeqfrees aidqtefena esnvkqniss krassgdens kkdnnektlk 721 tnltigdktq eqigenspss glhasssndd nfddaqeqq // LOCUS NP_014128 1953 aa linear PLN 30-JUN-2025 DEFINITION formin BNI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014128 VERSION NP_014128.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183109.2 REFERENCE 1 (residues 1 to 1953) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1953) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1953) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1953) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10289. On Apr 26, 2011 this sequence version replaced NP_014128.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1953 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1953 /product="formin BNI1" /calculated_mol_wt="219543" Region 178..458 /region_name="Drf_GBD" /note="Diaphanous GTPase-binding Domain; pfam06371" /db_xref="CDD:461886" Region 511..707 /region_name="Drf_FH3" /note="Diaphanous FH3 Domain; pfam06367" /db_xref="CDD:461885" Region <690..801 /region_name="PTZ00491" /note="major vault protein; Provisional" /db_xref="CDD:240439" Region 1348..1741 /region_name="FH2" /note="Formin Homology 2 Domain; pfam02181" /db_xref="CDD:396655" Region <1739..1841 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" CDS 1..1953 /gene="BNI1" /locus_tag="YNL271C" /gene_synonym="PPF3; SHE5" /coded_by="NM_001183109.2:1..5862" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11154270]" /experiment="EXISTENCE:direct assay:GO:0000133 polarisome [PMID:9571251|PMID:16166638]" /experiment="EXISTENCE:direct assay:GO:0005522 profilin binding [PMID:12134165|PMID:15923184]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:38656798]" /experiment="EXISTENCE:direct assay:GO:0005884 actin filament [PMID:12052901]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:11154270]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11154270]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:26771880]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807|PMID:38656798|PMID:9082982]" /experiment="EXISTENCE:direct assay:GO:0045010 actin nucleation [PMID:12052901]" /experiment="EXISTENCE:direct assay:GO:0051016 barbed-end actin filament capping [PMID:14561409]" /experiment="EXISTENCE:direct assay:GO:0070649 formin-nucleated actin cable assembly [PMID:12134165]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:17237521]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:23671312]" /experiment="EXISTENCE:genetic interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:11740491]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:17237521]" /experiment="EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:12419188]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:10085293]" /experiment="EXISTENCE:mutant phenotype:GO:0005522 profilin binding [PMID:15923184]" /experiment="EXISTENCE:mutant phenotype:GO:0005934 cellular bud tip [PMID:16166638]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:10866679]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:16166638|PMID:10085294]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:17237521]" /experiment="EXISTENCE:mutant phenotype:GO:0051017 actin filament bundle assembly [PMID:23671312]" /experiment="EXISTENCE:mutant phenotype:GO:0070649 formin-nucleated actin cable assembly [PMID:11740491]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:17237521]" /experiment="EXISTENCE:physical interaction:GO:0000133 polarisome [PMID:9571251]" /note="Formin; polarisome component; nucleates the formation of linear actin filaments, involved in budding and mitotic spindle orientation which require the formation of polarized actin cables; recruited to the division site in a Glc7p/Ref2p dependent manner following release of Bnr1p; spatially focuses Bni1p at mating projection tips, and with Bud6p organizes Bni1p into clusters that nucleate actin assembly during mating projection formation; some functional redundancy with BNR1" /db_xref="GeneID:855450" /db_xref="SGD:S000005215" ORIGIN 1 mlknsgskhs nskeshsnss sgifqnlkrl ansnatnsnt gsptyasqqq hspvgnevst 61 spassssfrk lnapsrstst earplnkkst lntqnlsqym ngklsgdvpv ssqharshsm 121 qskysyskrn ssqasnkltr qhtgqshsas sllsqgsltn lskfttpdgk iylempsdpy 181 evevlfedim ykrnifqsls edkqealmgy siekkwlivk qdlqnelkkm ranttsssta 241 srtsmasdhh piltanssls spksvlmtsa ssptstvysn slnhsttlss vgtstskgkk 301 lvsgslkkqp slnniyrgga enntsastlp gdrtnrppih yvqriladkl tsdemkdlwv 361 tlrteqldwv dafidhqghi amanvlmnsi yktaprenlt kellekensf fkcfrvlsml 421 sqglyefsth rlmtdtvaeg lfstklatrk mateifvcml ekknksrfea vltsldkkfr 481 igqnlhmiqn fkkmpqyfsh ltleshlkii qawlfaveqt ldgrgkmgsl vgasdefkng 541 ggenaileyc qwtmvfinhl cscsdninqr mllrtklenc gilrimnkik lldydkvidq 601 ielydnnkld dfnvkleann kafnvdlhdp lsllknlwdi ckgtenekll vslvqhlfls 661 ssklieenqn sskltkqlkl mdslvtnvsv astsdeetnm nmaiqrlyda mqtdevarra 721 ilesraltkk leeiqaerds lseklskaeh glvgqledel herdrilakn qrvmqqleae 781 leelkkkhll ekhqqevelr kmltilnsrp eesfnknegt rgmnsslnss ekaniqkvlq 841 dglsrakkdy kddskkfgmt lqpnkrlkml rmqmeniene arqlemtnfa efekdrlepp 901 ihikkpkvkk mknkdrkplv kpqeadvnkl ndlrralaei qmesndiskf nveervnelf 961 nekkslalkr lkeletkykg fgidfnvdei mdspkkntgd veteedanya sldpktyqkk 1021 ldeinritdq lldiqtqteh eiqveedges dlsssssdde seeiyqdasp tqelrsehse 1081 lssgsgpgsf ldalsqkygt gqnvtasaaf gennngsgig plhskvektf mnrlrkstvs 1141 sapyleeltq kvnkvepyeq nedegldkks lpenstasaa safdkaekdm rqhvengkqg 1201 rvvnheedkt adfsavskln ntdgaedlst qssvlssqpp ppppppppvp aklfgeslek 1261 ekkseddtvk qettgdspap pppppppppp pmalfgkpkg etppppplps vlssstdgvi 1321 ppappmmpas qiksavtspl lpqspslfek yprphkklkq lhwekldctd nsiwgtgkae 1381 kfaddlyekg vladlekafa areikslask rkedlqkitf lsrdisqqfg inlhmyssls 1441 vadlvkkiln cdrdflqtps vveflsksei ievsvnlarn yapystdweg vrnledakpp 1501 ekdpndlqra dqiylqlmvn lesywgsrmr altvvtsyer eynellaklr kvdkavsalq 1561 esdnlrnvfn vilavgnfmn dtskqaqgfk lstlqrltfi kdttnsmtfl nyvekivrln 1621 ypsfndflse lepvldvvkv sieqlvndck dfsqsivnve rsveignlsd sskfhpldkv 1681 liktlpvlpe arkkgdlled evkltimefe slmhtygeds gdkfakisff kkfadfiney 1741 kkaqaqnlaa eeeerlyikh kkiveeqqkr aqekekqken snspssegne edeaedrrav 1801 mdklleqlkn agpaksdpss arkralvrkk ylsekdnapq llndldteeg silyspeamd 1861 ptadtvihae sptplatrgv mntsedlpsp sktsaledqe eisdrarmll kelrgsdtpv 1921 kqnsildehl eklrarkers igeastgnrl sfk // LOCUS NP_014129 573 aa linear PLN 30-JUN-2025 DEFINITION arginine permease ALP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014129 VERSION NP_014129.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183108.1 REFERENCE 1 (residues 1 to 573) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 573) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 573) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 573) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10290. Method: conceptual translation. FEATURES Location/Qualifiers source 1..573 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..573 /product="arginine permease ALP1" /calculated_mol_wt="63883" Region 67..545 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..573 /gene="ALP1" /locus_tag="YNL270C" /gene_synonym="APL1" /coded_by="NM_001183108.1:1..1722" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015802 basic amino acid transport [PMID:10654085]" /note="Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication" /db_xref="GeneID:855451" /db_xref="SGD:S000005214" ORIGIN 1 mdetvniqms kegqyeinss siikeeefvd eqysgenvtk aitterkved daaketessp 61 qerrevkrkl kqrhigmial ggtigtglii gigpplahag pvgalisylf mgtviysvtq 121 slgemvtfip vtssfsvfaq rflspalgat ngymywlswc ftfalelsvl gkviqywtea 181 vplaawivif wclltsmnmf pvkyygefef ciasikvial lgfiifsfcv vcgagqsdgp 241 igfrywrnpg awgpgiissd knegrflgwv sslinaafty qgtelvgita geaanprkal 301 praikkvvvr ilvfyilslf figllvpynd pkldsdgifv ssspfmisie nsgtkvlpdi 361 fnavvlitil sagnsnvyig srvlyslskn slaprflsnv trggvpyfsv lstsvfgfla 421 flevsagsgk afnwllnitg vagffawlli sfshirfmqa irkrgisrdd lpykaqmmpf 481 layyasffia livliqgfta faptfqpidf vaayisiflf laiwlsfqvw fkcrllwklq 541 dididsdrrq ieelvwiepe cktrwqrvwd vls // LOCUS NP_014130 131 aa linear PLN 30-JUN-2025 DEFINITION Bsc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014130 VERSION NP_014130.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183107.1 REFERENCE 1 (residues 1 to 131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 131) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10291. Method: conceptual translation. FEATURES Location/Qualifiers source 1..131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..131 /product="Bsc4p" /calculated_mol_wt="15183" CDS 1..131 /gene="BSC4" /locus_tag="YNL269W" /coded_by="NM_001183107.1:1..396" /note="hypothetical protein; protein-coding gene that evolved de novo via a series of point mutations in noncoding sequence; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p; may be involved in DNA repair pathway during stationary phase and contribute to robustness of cells when shifted to a nutrient-poor environment" /db_xref="GeneID:855452" /db_xref="SGD:S000005213" ORIGIN 1 msivlrksnk knkncitskf ytihiikist pvfrapiaig espyvewscl qvvfrkdmvt 61 kkttfaqlit rlnhflcqal krrdsktyil crtavfgamt pfsprkshin nklpmqprkk 121 kiviiyvvrf h // LOCUS NP_014131 611 aa linear PLN 30-JUN-2025 DEFINITION lysine permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_014131 VERSION NP_014131.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183106.1 REFERENCE 1 (residues 1 to 611) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 611) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 611) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 611) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 611) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10292. Method: conceptual translation. FEATURES Location/Qualifiers source 1..611 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..611 /product="lysine permease" /calculated_mol_wt="67959" Region 107..583 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..611 /gene="LYP1" /locus_tag="YNL268W" /coded_by="NM_001183106.1:1..1836" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015174 basic amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015802 basic amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:29402931]" /experiment="EXISTENCE:genetic interaction:GO:0089718 amino acid import across plasma membrane [PMID:40247776]" /note="Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids; broad substrate specificity when overexpressed in a strain severely deficient for the uptake of amino acids; predominantly located in the plasma membrane during exponential growth" /db_xref="GeneID:855453" /db_xref="SGD:S000005212" ORIGIN 1 mgrfsniits nkwdekqnni geqsmqelpe dqiehemeai dpsnkttpys idekqyntkk 61 khgslqggai advnsitnsl trlqvvshet dinedeeeah yedkhvkral kqrhigmial 121 ggtigtglfv gistplsnag pvgsliayif mgtivyfvtq slgematfip vtssitvfsk 181 rflspafgvs ngymywfnwa ityavevsvi gqvieywtdk vplaawiaif wviitlmnff 241 pvkvygefef wvasvkvlai mgyliyalii vcggshqgpi gfrywrnpga wgpgiissdk 301 segrflgwvs slinaaftyq gtelvgitag eaanprktvp rainkvvfri vlfyimslff 361 igllvpynds rlsassavia sspfvisiqn agtyalpdif navvlitvvs aansnvyvgs 421 rvlyslartg napkqfgyvt rqgvpylgvv ctaalgllaf lvvnnnanta fnwlinistl 481 aglcawlfis lahirfmqal khrgisrddl pfkaklmpyg ayyaaffvtv iifiqgfqaf 541 cpfkvsefft syislillav vfigcqiyyk crfiwkledi didsdrreie aiiweddepk 601 nlwekfwaav a // LOCUS NP_014132 1066 aa linear PLN 30-JUN-2025 DEFINITION 1-phosphatidylinositol 4-kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014132 VERSION NP_014132.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183105.1 REFERENCE 1 (residues 1 to 1066) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1066) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1066) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1066) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1066) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10293. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1066 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1066 /product="1-phosphatidylinositol 4-kinase" /EC_number="2.7.1.67" /calculated_mol_wt="119793" Region <1..1066 /region_name="TEL1" /note="Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]; COG5032" /db_xref="CDD:227365" CDS 1..1066 /gene="PIK1" /locus_tag="YNL267W" /gene_synonym="PIK120; PIK41" /coded_by="NM_001183105.1:1..3201" /experiment="EXISTENCE:direct assay:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:8248783|PMID:8194527]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10587649|PMID:16365163|PMID:8194527]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:16365163|PMID:10587649]" /experiment="EXISTENCE:direct assay:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:8194527|PMID:8248783]" /experiment="EXISTENCE:mutant phenotype:GO:0004430 1-phosphatidylinositol 4-kinase activity [PMID:10587649]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:32726584]" /experiment="EXISTENCE:mutant phenotype:GO:0046854 phosphatidylinositol phosphate biosynthetic process [PMID:10587649]" /experiment="EXISTENCE:mutant phenotype:GO:0140504 microlipophagy [PMID:32726584]" /experiment="EXISTENCE:mutant phenotype:GO:2000786 positive regulation of autophagosome assembly [PMID:31125705]" /note="Phosphatidylinositol 4-kinase; catalyzes the first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; required for autophagosome formation during autophagy and for lipophagy in both stationary phase cells and during nitrogen starvation; may control nonselective autophagy and mitophagy through trafficking of Atg9p; localizes to the nucleus and to the trans-Golgi network" /db_xref="GeneID:855454" /db_xref="SGD:S000005211" ORIGIN 1 mhkassskks fddtielkkn eqllklinss eftlhncvel lckhsenigi hyylcqklat 61 fphselqfyi pqlvqvlvtm etesmaledl llrlraenph falltfwqlq alltdlstdp 121 asygfqvarr vlnnlqtnlf ntssgsdknv kihenvapal vlssmimsai afpqlsevtk 181 plvesqgrrq kafvfklars amkdftknmt lkntllnkkt srskrvssnr sstptspidl 241 idpiktkeda sfrksrhsev kldfdivddi gnqvfeeris ssiklpkrkp kyldnsyvhr 301 tydgkninrd gsisntakal dgnkgdyisp kgrndennei gnnedetgge teedadalns 361 dhftssmpdl hniqprtssa ssaslegtpk lnrtnsqpls rqafknskka nsslsqeidl 421 sqlsttskik mlkanyfrce tqfaialeti sqrlarvpte arlsalrael fllnrdlpae 481 vdiptllppn kkgklhklvt itaneaqvln saekvpylll ieylrdefdf dptsetnerl 541 lkkisgnqgg lifdlnymnr kennenrnes tltsnntrss vydsnsfnng asrneglsst 601 srsdsastah vrtevnkeed lgdmsmvkvr nrtddeayrn alviqsaanv pilpddsqdr 661 spelnfgsnl devliengin sknihsqtda ladqmrvsav mlaqldkspq qlsestkqir 721 aqiissmkev qdkfgyhdle alhgmagerk lendlmtggi dtsylgedwa tkkerirkts 781 eyghfenwdl csviaktgdd lrqeafayqm iqamaniwvk ekvdvwvkrm kilitsantg 841 lvetitnams vhsikkaltk kmiedaeldd kggiaslndh flrafgnpng fkyrraqdnf 901 asslaaysvi cyllqvkdrh ngnimidneg hvshidfgfm lsnspgsvgf eaapfkltye 961 yiellggveg eafkkfvelt kssfkalrky adqivsmcei mqkdnmqpcf dageqtsvql 1021 rqrfqldlse kevddfvenf ligkslgsiy triydqfqli tqgiys // LOCUS NP_014134 298 aa linear PLN 30-JUN-2025 DEFINITION Ist1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014134 VERSION NP_014134.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183103.1 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10294. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..298 /product="Ist1p" /calculated_mol_wt="34365" Region 13..183 /region_name="Ist1" /note="Regulator of Vps4 activity in the MVB pathway; pfam03398" /db_xref="CDD:460910" CDS 1..298 /gene="IST1" /locus_tag="YNL265C" /coded_by="NM_001183103.1:1..897" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18032584]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:36125415|PMID:14562095|PMID:18032584]" /experiment="EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:18032582]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18032584]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18032582]" /experiment="EXISTENCE:mutant phenotype:GO:0042030 ATPase inhibitor activity [PMID:36125415]" /experiment="EXISTENCE:mutant phenotype:GO:0099638 endosome to plasma membrane protein transport [PMID:36125415]" /note="Protein involved in recycling of membrane transporters from endosome to plasma membrane; plays a role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p" /db_xref="GeneID:855456" /db_xref="SGD:S000005209" ORIGIN 1 mapsmipfti klktclkmci qrlryaqekq qaiakqsrrq vaqllltnke qkahyrvetl 61 ihddihiell eilelycell larvqvindi steeqlvkeh mddgineair sliyailfvd 121 evkelsqlkd lmawkinvef vngviadhid vpekiikkcs psvpkeelvd lylkeiakty 181 dvpysklens lsssssniss dfsdpsgdie dndeekpila ldnddndnad akhpitvkkp 241 rqnsenikne lkipkdikke viekkqsekk ttkrktkkeq endeldelkk rfdalrrk // LOCUS NP_014135 350 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_014135 VERSION NP_014135.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183102.1 REFERENCE 1 (residues 1 to 350) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 350) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 350) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 350) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10295. Method: conceptual translation. FEATURES Location/Qualifiers source 1..350 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..350 /product="phosphatidylinositol transporter" /calculated_mol_wt="40547" Region 49..115 /region_name="CRAL_TRIO_N" /note="CRAL/TRIO, N-terminal domain; pfam03765" /db_xref="CDD:461043" Region 146..291 /region_name="CRAL_TRIO" /note="CRAL/TRIO domain; pfam00650" /db_xref="CDD:459890" CDS 1..350 /gene="PDR17" /locus_tag="YNL264C" /gene_synonym="ISS1; SFH4" /coded_by="NM_001183102.1:1..1053" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:20016005]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:12869188]" /experiment="EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10799527|PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10848624|PMID:10799527]" /experiment="EXISTENCE:direct assay:GO:0016126 sterol biosynthetic process [PMID:36482167]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:36482167]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:12869188]" /experiment="EXISTENCE:genetic interaction:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0008654 phospholipid biosynthetic process [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0009410 response to xenobiotic stimulus [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0043001 Golgi to plasma membrane protein transport [PMID:10848624]" /experiment="EXISTENCE:genetic interaction:GO:1901352 negative regulation of phosphatidylglycerol biosynthetic process [PMID:12869188]" /experiment="EXISTENCE:genetic interaction:GO:2001247 positive regulation of phosphatidylcholine biosynthetic process [PMID:12869188]" /experiment="EXISTENCE:mutant phenotype:GO:0006658 phosphatidylserine metabolic process [PMID:10799527]" /experiment="EXISTENCE:mutant phenotype:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]" /experiment="EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:9890948]" /note="Phosphatidylinositol transfer protein (PITP); downregulates Plb1p-mediated turnover of phosphatidylcholine; forms a complex with Psd2p which appears essential for maintenance of vacuolar PE levels; found in the cytosol and microsomes; homologous to Pdr16p; deletion affects phospholipid composition" /db_xref="GeneID:855457" /db_xref="SGD:S000005208" ORIGIN 1 mglfsrkrdh tpavpkekli pcdkifldpp akygnaplle pisedqneky ravlrhfqdd 61 dlklpenlnd ldngthandr plsdwekfwl srecflrylr ankwntanai kgltktlvwr 121 reiglthgke dkdpltadkv avenetgkqv ilgfdnakrp lyymkngrqn tessfrqvqe 181 lvymmetatt vapqgvekit vlvdfksyke pgiitdkapp isiarmclnv mqdhyperla 241 kcvlinipwf awaflkmmyp fldpatkaka ifdepfenhi epsqldalyn glldfkykhe 301 vywpdmvkkv ddlrlkrfdr flkfggivgl seydtkgqhd elkypvdmvi // LOCUS NP_014136 314 aa linear PLN 30-JUN-2025 DEFINITION protein transporter YIF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014136 VERSION NP_014136.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183101.1 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10296. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..314 /product="protein transporter YIF1" /calculated_mol_wt="35367" Region 22..314 /region_name="COG5197" /note="Predicted membrane protein [Function unknown]" /db_xref="CDD:227524" CDS 1..314 /gene="YIF1" /locus_tag="YNL263C" /coded_by="NM_001183101.1:1..945" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:10970842]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10970842]" /experiment="EXISTENCE:physical interaction:GO:0005789 endoplasmic reticulum membrane [PMID:15659647]" /note="Integral membrane protein; required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3" /db_xref="GeneID:855458" /db_xref="SGD:S000005207" ORIGIN 1 msynpyayat seqngvndrf shtpqqqrpm qiprntpvng qgnanmnanv ngsgggfpfq 61 dprgsmafql gqsafsnfig qdnfnqfqet vnkatanaag sqqistyfqv stryvinklk 121 lilvpflngt knwqrimdsg nflpprddvn spdmympimg lvtyiliwnt qqglkgsfnp 181 edlyyklsst lafvcldlli lklglyllid skipsfslve llcyvgykfv plilaqlltn 241 vtmpfnlnil ikfylfiafg vfllrsvkfn llsrsgaedd dihvsiskst vkkcnyflfv 301 ygfiwqnvlm wlmg // LOCUS NP_014137 2222 aa linear PLN 30-JUN-2025 DEFINITION DNA polymerase epsilon catalytic subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_014137 VERSION NP_014137.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183100.1 REFERENCE 1 (residues 1 to 2222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2222) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 2222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 2222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10297. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..2222 /product="DNA polymerase epsilon catalytic subunit" /EC_number="2.7.7.7" /calculated_mol_wt="255541" Region 121..442 /region_name="DNA_pol_B_exo1" /note="DNA polymerase family B, exonuclease domain; pfam03104" /db_xref="CDD:397292" Region 283..486 /region_name="DNA_polB_epsilon_exo" /note="DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase; cd05779" /db_xref="CDD:99822" Site order(290..293,377..378,381..383,438..439,473,477) /site_type="active" /db_xref="CDD:99822" Site order(290,292,383,473,477) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:99822" Site order(291..293,377..378,381..382,438..439,473,477) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:99822" Region 545..1166 /region_name="POLBc_epsilon" /note="DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed...; cd05535" /db_xref="CDD:99918" Site order(640,643..645,778,824,828,877) /site_type="active" /db_xref="CDD:99918" Site order(875,877..878) /site_type="metal-binding" /db_xref="CDD:99918" Region 1528..1920 /region_name="DUF1744" /note="Domain of unknown function (DUF1744); pfam08490" /db_xref="CDD:462493" CDS 1..2222 /gene="POL2" /locus_tag="YNL262W" /gene_synonym="DUN2" /coded_by="NM_001183100.1:1..6669" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:16916794|PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:15773893|PMID:18851837]" /experiment="EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:14622139|PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0008622 epsilon DNA polymerase complex [PMID:12571237|PMID:2406268]" /experiment="EXISTENCE:direct assay:GO:0032183 SUMO binding [PMID:31765407]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:19776424]" /experiment="EXISTENCE:genetic interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18437220]" /experiment="EXISTENCE:genetic interaction:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:18851837|PMID:8895664]" /experiment="EXISTENCE:mutant phenotype:GO:0003887 DNA-directed DNA polymerase activity [PMID:1537345]" /experiment="EXISTENCE:mutant phenotype:GO:0006272 leading strand elongation [PMID:17615360]" /experiment="EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:8423775]" /experiment="EXISTENCE:mutant phenotype:GO:0006297 nucleotide-excision repair, DNA gap filling [PMID:11452038]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:10025407]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18437220]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:12665575]" /experiment="EXISTENCE:mutant phenotype:GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity [PMID:1658784]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:8895664]" /experiment="EXISTENCE:mutant phenotype:GO:0033314 mitotic DNA replication checkpoint signaling [PMID:9792727]" /experiment="EXISTENCE:mutant phenotype:GO:0035822 gene conversion [PMID:20595613]" /experiment="EXISTENCE:mutant phenotype:GO:0045004 DNA replication proofreading [PMID:21124948|PMID:1658784]" /experiment="EXISTENCE:physical interaction:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:18851837]" /note="Catalytic subunit of DNA polymerase (II) epsilon; a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; participates in leading-strand synthesis during DNA replication; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p" /db_xref="GeneID:855459" /db_xref="SGD:S000005206" ORIGIN 1 mmfgkkknng gsstarysag nkyntlsnny alsaqqllna skiddidsmm gferyvppqy 61 ngrfdakdid qipgrvgwlt nmhatlvsqe tlssgsnggg nsndgervtt nqgisgvdfy 121 fldeeggsfk stvvydpyff iacndesrvn dveelvkkyl esclkslqii rkedltmdnh 181 llglqktlik lsfvnsnqlf earkllrpil qdnannnvqr niynvaangs ekvdakhlie 241 direydvpyh vrvsidkdir vgkwykvtqq gfiedtrkia fadpvvmafd iettkpplkf 301 pdsavdqimm isymidgegf litnreiise diedfeytpk peypgfftif nendevallq 361 rffehirdvr ptvistfngd ffdwpfihnr skihgldmfd eigfapdaeg eykssycshm 421 dcfrwvkrds ylpqgsqglk avtqsklgyn pieldpelmt pyafekpqhl seysvsdava 481 tyylymkyvh pfifslctii plnpdetlrk gtgtlcemll mvqayqhnil lpnkhtdpie 541 rfydghlles etyvgghves leagvfrsdl knefkidpsa idellqelpe alkfsveven 601 kssvdkvtnf eeiknqitqk llelkennir nelpliyhvd vasmypnimt tnrlqpdsik 661 aerdcascdf nrpgktcark lkwawrgeff pskmdeynmi kralqnetfp nknkfskkkv 721 ltfdelsyad qvihikkrlt eysrkvyhrv kvseiverea ivcqrenpfy vdtvksfrdr 781 ryefkglakt wkgnlskidp sdkhardeak kmivlydslq lahkvilnsf ygyvmrkgsr 841 wysmemagit cltgatiiqm aralvervgr pleldtdgiw cilpksfpet yfftlengkk 901 lylsypcsml nyrvhqkftn hqyqelkdpl nyiyethsen tiffevdgpy kamilpsske 961 egkgikkrya vfnedgslae lkgfelkrrg elqliknfqs difkvflegd tlegcysava 1021 svcnrwldvl dshglmlede dlvslicenr smsktlkeye gqkstsitta rrlgdflged 1081 mvkdkglqck yiisskpfna pvteraipva ifsadipikr sflrrwtldp sledldirti 1141 idwgyyrerl gsaiqkiiti paalqgvsnp vprvehpdwl krkiatkedk fkqtsltkff 1201 sktknvptmg kikdiedlfe ptveednaki kiarttkkka vskrkrnqlt needplvlps 1261 eipsmdedyv gwlnyqkikw kiqardrkrr dqlfgntnss rersalgsmi rkqaesyans 1321 twevlqykds gepgvlevfv tingkvqnit fhipktiymk fksqtmplqk ikncliekss 1381 aslpnnpkts npaggqlfki tlpesvflee kenctsifnd envlgvfegt itphqraimd 1441 lgasvtfrsk amgalgkgiq qgfemkdlsm aenerylsgf smdigyllhf ptsigyeffs 1501 lfkswgdtit ilvlkpsnqa qeinasslgq iykqmfekkk gkietysylv dikedinfef 1561 vyftdiskly rrlsqettkl keerglqfll llqspfitkl lgtirllnqm pivklslnev 1621 llpqlnwqpt llkklvnhvl ssgswishli klsqysnipi cnlrldsmdy iidvlyarkl 1681 kkenivlwwn ekaplpdhgg iqndfdlnts wimndsefpk innsgvydnv vldvgvdnlt 1741 vntiltsali ndaegsdlvn nnmgiddkda vinspsefvh dafsndalnv lrgmlkewwd 1801 ealkenstad llvnslaswv qnpnaklfdg llryhvhnlt kkallqlvne fsalgstivy 1861 adrnqilikt nkyspencya ysqymmkavr tnpmfsyldl nikrywdlli wmdkfnfsgl 1921 acieieeken qdytavsqwq lkkflspiyq pefedwmmii ldsmlktkqs ylklnsgtqr 1981 ptqivnvkkq dkedsvensl ngfshlfskp lmkrvkklfk nqqefildpq yeadyvipvl 2041 pgshlnvknp llelvkslch vmllskstil eirtlrkell kifelrefak vaefkdpsls 2101 lvvpdflcey cffisdidfc kaapesifsc vrchkafnqv llqehliqkl rsdiesyliq 2161 dlrcsrchkv krdymsahcp cagawegtlp resivqklnv fkqvakyygf dillsciadl 2221 ti // LOCUS NP_014138 479 aa linear PLN 30-JUN-2025 DEFINITION origin recognition complex subunit 5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014138 VERSION NP_014138.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183099.1 REFERENCE 1 (residues 1 to 479) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 479) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 479) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 479) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10298. Method: conceptual translation. FEATURES Location/Qualifiers source 1..479 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..479 /product="origin recognition complex subunit 5" /calculated_mol_wt="55159" Region 11..146 /region_name="AAA_16" /note="AAA ATPase domain; pfam13191" /db_xref="CDD:433025" Region 189..474 /region_name="ORC5_C" /note="Origin recognition complex (ORC) subunit 5 C-terminus; pfam14630" /db_xref="CDD:464224" CDS 1..479 /gene="ORC5" /locus_tag="YNL261W" /coded_by="NM_001183099.1:1..1440" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]" /experiment="EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:7579692]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:9038340]" /experiment="EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16716188|PMID:7579692]" /note="Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing" /db_xref="GeneID:855460" /db_xref="SGD:S000005205" ORIGIN 1 mnvttpevaf reyqtnclas yisadpditp snlilqgysg tgktytlkky fnanpnlhav 61 wlepvelvsw kpllqaiart vqyklktlyp nipttdydpl qveepfllvk tlhnifvqye 121 slqektclfl ildgfdslqd ldaalfnkyi klnellpkds kinikfiytm letsflqrys 181 thciptvmfp rynvdevsti lvmsrcgelm edsclrkrii eeqitdctdd qfqnvaanfi 241 hlivqafhsy tgndifalnd lidfkwpkyv sritkenife plalyksaik lflstddnls 301 engqgesait tnrddlensq tydlsiisky lliasyicsy leprydasif srktriiqgr 361 aaygrrkkke vnprylqpsl faierllaif qaifpiqgka esgslsalre eslmkaniev 421 fqnlselhtl kliattmnkn idylspkvrw kvnvpweiik eisesvhfni sdyfsdihe // LOCUS NP_014139 162 aa linear PLN 30-JUN-2025 DEFINITION ribosome biosynthesis protein LTO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014139 VERSION NP_014139.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183098.2 REFERENCE 1 (residues 1 to 162) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 162) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 162) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 162) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10299. On May 27, 2021 this sequence version replaced NP_014139.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..162 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..162 /product="ribosome biosynthesis protein LTO1" /calculated_mol_wt="18764" Region 17..55 /region_name="Yae1_N" /note="Essential protein Yae1, N terminal; pfam09811" /db_xref="CDD:430844" CDS 1..162 /gene="LTO1" /locus_tag="YNL260C" /coded_by="NM_001183098.2:1..489" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23318452|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:26182403]" /experiment="EXISTENCE:direct assay:GO:0062092 Yae1-Lto1 complex [PMID:26182403]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:26182403]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:26182403]" /experiment="EXISTENCE:mutant phenotype:GO:0062092 Yae1-Lto1 complex [PMID:26182403]" /note="Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human ORAOV1, which is overexpressed in solid tumors; co-expression of ORAOV1 and YAE1 homolog YAE1D1 restores growth and Rli1p maturation after LTO1 depletion" /db_xref="GeneID:855461" /db_xref="SGD:S000005204" ORIGIN 1 mdfdnllnle eqyyqegfle gqnenikqsf legkqyglqv gfqrftllgq meglcdvies 61 yglhsptlek nihtirtlmk glkmnnddes vmefervlik lknkfrtili tlhrlvkdkr 121 tptvtfevfe dvsraiagei rgfvenedia knktkqnqaq sw // LOCUS NP_014140 73 aa linear PLN 30-JUN-2025 DEFINITION copper metallochaperone ATX1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014140 VERSION NP_014140.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183097.1 REFERENCE 1 (residues 1 to 73) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 73) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 73) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 73) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10300. Method: conceptual translation. FEATURES Location/Qualifiers source 1..73 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..73 /product="copper metallochaperone ATX1" /calculated_mol_wt="8089" Region 13..68 /region_name="HMA" /note="Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; cd00371" /db_xref="CDD:238219" Site order(13..15,18) /site_type="metal-binding" /note="metal-binding site [ion binding]" /db_xref="CDD:238219" CDS 1..73 /gene="ATX1" /locus_tag="YNL259C" /coded_by="NM_001183097.1:1..222" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9083054]" /experiment="EXISTENCE:direct assay:GO:0016531 copper chaperone activity [PMID:9346482|PMID:17961510]" /experiment="EXISTENCE:mutant phenotype:GO:0006825 copper ion transport [PMID:9083054]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9083054]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:7731983]" /note="Cytosolic copper metallochaperone; transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake; human homolog ATOX1 can complement yeast atx1 mutant; overexpression of human ATOX1 suppresses lysine auxotrophy of the yeast sod1 null mutant, as does overexpression of yeast ATX1" /db_xref="GeneID:855462" /db_xref="SGD:S000005203" ORIGIN 1 maeikhyqfn vvmtcsgcsg avnkvltkle pdvskidisl ekqlvdvytt lpydfileki 61 kktgkevrsg kql // LOCUS NP_014141 754 aa linear PLN 30-JUN-2025 DEFINITION Dsl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014141 VERSION NP_014141.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183096.1 REFERENCE 1 (residues 1 to 754) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 754) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 754) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 754) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10301. Method: conceptual translation. FEATURES Location/Qualifiers source 1..754 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..754 /product="Dsl1p" /calculated_mol_wt="87941" Region 6..360 /region_name="Dsl1_N" /note="Retrograde transport protein Dsl1 N terminal; pfam11988" /db_xref="CDD:403266" Region 560..753 /region_name="Dsl1_C" /note="Retrograde transport protein Dsl1 C terminal; pfam11989" /db_xref="CDD:432242" CDS 1..754 /gene="DSL1" /locus_tag="YNL258C" /gene_synonym="RNS1" /coded_by="NM_001183096.1:1..2265" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15942868]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11739780]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0070939 Dsl1/NZR complex [PMID:19151722]" /experiment="EXISTENCE:genetic interaction:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11493604]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:11739780|PMID:11493604]" /experiment="EXISTENCE:mutant phenotype:GO:0032581 ER-dependent peroxisome organization [PMID:19346454]" /experiment="EXISTENCE:physical interaction:GO:0070939 Dsl1/NZR complex [PMID:15958492]" /note="Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; mediates Sey1p-independent homotypic ER fusion; forms Dsl1 tethering complex with Sec39p and Tip20p that forms a stable complex with ER SNAREs Sec20p, Ufe1p and Use1p and is functionally conserved from yeast to mammalian cells; component of the ER target site that interacts with coatomer; interacts with different subunits of COPI vesicle coat; interacts with Cin5p; homolog of fly and human ZW10 gene" /db_xref="GeneID:855463" /db_xref="SGD:S000005202" ORIGIN 1 meslfpnkge iirellkdpl ilkndskrsn gseleldssd llqreailan elnildnlkt 61 flnlikevkt nlnilelenc yyslqslrkk mrnnaaylkq sfnfqqsist yvdtlhlelv 121 stlykiltng fwkitensiq ftptvewgkd kvhieydtfm dfvaqqyfpk gsldnqawfi 181 ldmtsadsqe qvraklntim keymnlsriv smiknsifis gkeisyenek nilvfsksss 241 hgqhcvstvl tsfeavcdfm ldglafrdrk tlsyelgplf nteftkfvkn nasiilesld 301 splknlvsvi nnkltrlvak sevtnwthsg keiqdllmnk qlyynllldk vleshiseir 361 sifedpkksw qnlevveltt sntntmseki gkndsdvqne kelhnavskd ddwnwevedd 421 dadawgdeid vniddeeekt nqekekepee eenawdeawa ideniddasl engkehlkah 481 dvgsldkdhi evtqlpklfl aisqnfkssf adshvdeqyf aykynllqts ymamctanfs 541 hnwcqlyvdm rylierdekl yrikeltrnl letklnmkyr ivcqlirhql tefrenernp 601 swdatiekll pyilkeivrp lqkirgeegs ryllsflnfl yndcvtkeil kwqiisevns 661 enlgelvsll vnntdiqlla kepsykkmre kfatmgkflp lhlkeimemf yngdfylfat 721 deliqwiell fadtplrrna iddiyeirgt aldd // LOCUS NP_014142 1229 aa linear PLN 30-JUN-2025 DEFINITION Sip3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014142 VERSION NP_014142.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183095.1 REFERENCE 1 (residues 1 to 1229) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1229) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1229) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1229) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10302. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1229 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1229 /product="Sip3p" /calculated_mol_wt="142689" Region 32..253 /region_name="BAR_SIP3_fungi" /note="The Bin/Amphiphysin/Rvs (BAR) domain of fungal Snf1p-interacting protein 3; cd07609" /db_xref="CDD:153293" Site order(40,43..44,48,50..51,54..55,57..58,62..63,65..66, 69..70,72..73,76,88,91..92,201,204..205,207..208,211..212, 214..215,218..219,222..223,225..226,240..241,243..244) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153293" Region 311..427 /region_name="PH_SIP3" /note="Snf1p-interacting protein 3 Pleckstrin homology (PH) domain; cd13280" /db_xref="CDD:270098" Region 776..946 /region_name="VASt" /note="VAD1 Analog of StAR-related lipid transfer domain; pfam16016" /db_xref="CDD:464975" CDS 1..1229 /gene="SIP3" /locus_tag="YNL257C" /gene_synonym="LAM3" /coded_by="NM_001183095.1:1..3690" /experiment="EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:8127709]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:26001273]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8127709]" /experiment="EXISTENCE:mutant phenotype:GO:0032366 intracellular sterol transport [PMID:26001273]" /note="Putative sterol transfer protein; has a probable role in retrograde transport of sterols from the plasma membrane to the ER; co-localizes to puncta in the cortical ER with Ysp2p; contains GRAM, StART-like (VASt) and two PH-like domains; one of 6 StART-like domain-containing proteins in yeast that may be involved in sterol transfer between intracellular membranes; conserved across eukaryotes; previously identified as a transcription cofactor that interacts with DNA-bound Snf1p" /db_xref="GeneID:855464" /db_xref="SGD:S000005201" ORIGIN 1 msvhgrdpkk rqlrlisvaf keasidspsf rasvnffqtr vdaledwiek tvdffdqkyk 61 vsfedfrrak etllsqllpp pallsngfvs nqsftprlid sfnkdyydfs mkllqivkgd 121 dsshstalle lmttaiepyr nvrknfdfyq gkydsmlasy qairisktsl epssiksdal 181 qlfevqknyl kasldlisai savklsldkf ilesmkvlks rsifitkdsg rkidlspcin 241 eyldnyaiwv ensiegskvl dsdisnakkq ayrytlkrit pssdtsdyni rsihssklls 301 kdtqvppksp eksgwlymkt qvgkptreiw vrrwcflkna vfgmfllsps ktyveetdkf 361 gvfltnvryd peedrkfcfe vkifgnkvte ahdnmskdit lvfqtsnyld lkswliafea 421 tkkyvmsiqh dsleyelafk rfspkffefa sstttsidql ittfdketes lyetlncsis 481 eydiltlgee kvfqfqmptt pistkmtqla ilsnfltkgs wfpnavlani wgttdwseyt 541 ilpgkgkkps slltidgkrl pirnstiypq yysnelkvld lqfkslvfsp dqrleklpee 601 lllfkfealw cpnkkqkfsa tcfctkdyiy cymnsmefic ltkislseiv sveadrsskk 661 tlklydasgl qmkaivlfsd ykliasklqy llenkaiknp nsneeilvkf eqmekesqek 721 kqeelykieq ensfdrkats vskiiksrvt fwemsddast llnrlkklqt eysitynhey 781 eisskglahi lfgdksnafp kclflarkdg eehgkrfwyk nkdingksql vrkipfrldm 841 tgnflntgky hrdkeskmif atqrivkivd nkyyevdldp ffvkvpfchl lklsikfvit 901 esydvdnhle iklnmtasss slhvlykley idsrtgktie klslaeiicq twalkfahse 961 fllirrvlry ylekigkhgk vikaiklcgi lgvlsnksee patekngnsk esesmqydir 1021 ysctilflvf iklmvyrvtn ltfvffrili gilllcaekf srinrmmvvg llasiminil 1081 lsekasvpyw sikraeklfh drlgsdkftm qraiyisdsd llssqlsvps nnpifekfse 1141 dnfnkdyqys etrkqlamrr nellielril qdmekqlvhd dyekflleev nkcsmvsiem 1201 tdlwfndtql qnycsicnee leklrppit // LOCUS NP_014143 824 aa linear PLN 30-JUN-2025 DEFINITION trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014143 VERSION NP_014143.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183094.1 REFERENCE 1 (residues 1 to 824) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 824) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 824) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 824) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 824) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 824) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 824) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 824) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10303. On Oct 2, 2003 this sequence version replaced NP_014143.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..824 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..824 /product="trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1" /EC_number="2.5.1.15" /EC_number="2.7.6.3" /EC_number="4.1.2.25" /calculated_mol_wt="92989" Region 21..138 /region_name="folB_dom" /note="FolB domain; TIGR00526" /db_xref="CDD:273120" Site order(22..32,38..46,122..123,128..136) /site_type="other" /note="homooctamer interface [polypeptide binding]" /db_xref="CDD:238298" Site order(36..38,41,91..94,120,134) /site_type="active" /db_xref="CDD:238298" Region 146..259 /region_name="TFold" /note="Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA), GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; cl00263" /db_xref="CDD:469697" Site order(147..157,163..171,243..244,247..255) /site_type="other" /note="homooctamer interface [polypeptide binding]" /db_xref="CDD:238298" Site order(161..163,166,208..211,241,253) /site_type="active" /db_xref="CDD:238298" Region 300..433 /region_name="HPPK" /note="7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; cd00483" /db_xref="CDD:238269" Site order(305,339..340,342,350,352,367,371,374,380,382,386,389, 392,394..395,414,417..418,423,425) /site_type="active" /note="catalytic center binding site [active]" /db_xref="CDD:238269" Site order(367,371,374,380,382,389,394..395,414,417..418,423) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238269" Region 498..822 /region_name="FolP" /note="Dihydropteroate synthase [Coenzyme transport and metabolism]; COG0294" /db_xref="CDD:440063" CDS 1..824 /gene="FOL1" /locus_tag="YNL256W" /coded_by="NM_001183094.1:1..2475" /experiment="EXISTENCE:direct assay:GO:0003848 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [PMID:15169867]" /experiment="EXISTENCE:direct assay:GO:0004150 dihydroneopterin aldolase activity [PMID:15169867]" /experiment="EXISTENCE:direct assay:GO:0004156 dihydropteroate synthase activity [PMID:15169867]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8813764]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:15169867]" /experiment="EXISTENCE:mutant phenotype:GO:0004156 dihydropteroate synthase activity [PMID:11731153]" /experiment="EXISTENCE:mutant phenotype:GO:0046654 tetrahydrofolate biosynthetic process [PMID:15169867|PMID:11731153]" /note="Multifunctional enzyme of the folic acid biosynthesis pathway; has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities" /db_xref="GeneID:855465" /db_xref="SGD:S000005200" ORIGIN 1 msklfstvns arhsvplggm rdyvhikkle mntvlgpdsw nqlmpqkcll sldmgtdfsk 61 saatddlkys lnyavisrdl tnfvskkknw gsvsnlaksv sqfvmdkysg veclnlevqa 121 dtthirsdhi sciiqqergn pesqefdvvr iselkmltli gvftferlkk qyvtldiklp 181 wpkkaelppp vqsiidnvvk fveesnfktv ealvesvsav iahneyfqkf pdsplvvkvl 241 klnaitateg vgvscirepr eiamvnipyl ssihessdik fqlsssqntp iegkntwkra 301 flafgsnigd rfkhiqmalq llsrektvkl rnissifese pmyfkdqtpf mngcvevetl 361 ltpsellklc kkieyeelqr vkhfdngprt idldivmfln sagediivne pdlniphprm 421 lertfvlepl celispvhlh pvtaepivdh lkqlydkqhd edtlwklvpl pyrsgveprf 481 lkfktatkld eftgetnrit vsptyimaif natpdsfsdg gehfadiesq lndiiklckd 541 alylhesvii dvggcstrpn siqaseeeei rrsiplikai restelpqdk vilsidtyrs 601 nvakeaikvg vdiindisgg lfdsnmfavi aenpeicyil shtrgdistm nrlahyenfa 661 lgdsiqqefv hntdiqqldd lkdktvlirn vgqeigeryi kaidngvkrw qilidpglgf 721 aktwkqnlqi irhipilkny sftmnsnnsq vyvnlrnmpv llgpsrkkfi ghitkdvdak 781 qrdfatgavv ascigfgsdm vrvhdvkncs ksikladaiy kgle // LOCUS NP_014144 153 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding translational activator GIS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014144 VERSION NP_014144.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183093.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10304. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..153 /product="mRNA-binding translational activator GIS2" /calculated_mol_wt="16972" Region <1..129 /region_name="AIR1" /note="Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; COG5082" /db_xref="CDD:227414" CDS 1..153 /gene="GIS2" /locus_tag="YNL255C" /coded_by="NM_001183093.1:1..462" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23285195|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:21232131]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21232131|PMID:23222640|PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23285195]" /experiment="EXISTENCE:direct assay:GO:0045182 translation regulator activity [PMID:21277287]" /experiment="EXISTENCE:direct assay:GO:2000767 positive regulation of cytoplasmic translation [PMID:21277287]" /note="Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2" /db_xref="GeneID:855466" /db_xref="SGD:S000005199" ORIGIN 1 msqkacyvcg kighlaedcd serlcyncnk pghvqtdctm prtvefkqcy ncgetghvrs 61 ectvqrcfnc nqtghisrec pepkktsrfs kvscykcggp nhmakdcmke dgisglkcyt 121 cgqaghmsrd cqndrlcync netghiskdc pka // LOCUS NP_014145 401 aa linear PLN 30-JUN-2025 DEFINITION Rtc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014145 VERSION NP_014145.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183092.1 REFERENCE 1 (residues 1 to 401) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 401) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 401) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 401) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10305. Method: conceptual translation. FEATURES Location/Qualifiers source 1..401 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..401 /product="Rtc4p" /calculated_mol_wt="46081" Region 218..364 /region_name="RTC4" /note="RTC4-like domain; pfam14474" /db_xref="CDD:464184" CDS 1..401 /gene="RTC4" /locus_tag="YNL254C" /coded_by="NM_001183092.1:1..1206" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /db_xref="GeneID:855467" /db_xref="SGD:S000005198" ORIGIN 1 mvgpglginr vrrkgvystk kgsgdnlllm krqgkhdihd resddlsghd afspskkrgk 61 idsitedeie vkklstvatf dklsrsfpns evqaaknaal rgkekeeekv vsipliqnlk 121 nediesikcr nnnlldgkkl lleaelsave dnqifsssfp edkklslqsc lsskeqiikk 181 lqvreeymsk fklppmlfsd elltevepfm pivmdilegk issvyyfeak nafknsqkay 241 lsvdefrkln lnkftagfyg lkrqlrvgee iakrykralt hnqpatlkww gitdfcnyvl 301 apetltsfci yqlnlsnksc ssktpnkhpk qqlnekeyyy dpelrmlayd lledtveygi 361 ivadsdpieq weaaieedrl relkldvhny ssrrwrldth d // LOCUS NP_014146 422 aa linear PLN 30-JUN-2025 DEFINITION Tex1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014146 VERSION NP_014146.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183091.1 REFERENCE 1 (residues 1 to 422) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 422) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 422) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 422) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 422) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10306. Method: conceptual translation. FEATURES Location/Qualifiers source 1..422 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..422 /product="Tex1p" /calculated_mol_wt="47036" Region <63..331 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 66..109 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 116..158 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 163..205 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 213..249 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 256..290 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 298..336 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..422 /gene="TEX1" /locus_tag="YNL253W" /coded_by="NM_001183091.1:1..1269" /experiment="EXISTENCE:curator inference:GO:0006406 mRNA export from nucleus [PMID:11979277]" /experiment="EXISTENCE:direct assay:GO:0000346 transcription export complex [PMID:11979277]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /note="Protein involved in mRNA export; component of the transcription export (TREX) complex" /db_xref="GeneID:855468" /db_xref="SGD:S000005197" ORIGIN 1 mstigavdil nqktitseva asvtskylqs tfskgntshi edkrfihvss rshsrftstp 61 itpneilslk fhvsgssmay srmdgsltvw fikdasfdks vevyipdccg sdklatdlsw 121 nptslnqiav vsnsseisll lineksltas klrtlslgsk tkvntclydp lgnwllaatk 181 sekiylfdvk kdhssvcsln isdisqednd vvyslawsng gshifigfks gylailkakh 241 gilevctkik ahtgpiteik mdpwgrnfit gsidgncyvw nmkslcceli indlnsavtt 301 ldvchlgkil gictedemvy fydlnsgnll hskslanykt dpvlkfypdk swyimsgknd 361 tlsnhfvkne knlitywkdm fdntmiekrr knngggnnhn krtskntdri gkdrpsrfns 421 kk // LOCUS NP_014147 281 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL46 MRPL17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014147 VERSION NP_014147.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183090.1 REFERENCE 1 (residues 1 to 281) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 281) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 281) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 281) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10307. Method: conceptual translation. FEATURES Location/Qualifiers source 1..281 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..281 /product="mitochondrial 54S ribosomal protein mL46 MRPL17" /calculated_mol_wt="32082" Region 23..150 /region_name="MRP-L46" /note="39S mitochondrial ribosomal protein L46; pfam11788" /db_xref="CDD:432074" Region 145..277 /region_name="NUDIX_MRP_L46" /note="Mitochondrial ribosomal protein L46; cd04661" /db_xref="CDD:467546" CDS 1..281 /gene="MRPL17" /locus_tag="YNL252C" /gene_synonym="mL46; MRPL30" /coded_by="NM_001183090.1:1..846" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552|PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:855469" /db_xref="SGD:S000005196" ORIGIN 1 mkvnlmlkrg latatatass appkikvgvl lsripiikse lnelekkyye yqselekrlm 61 wtfpayfyfk kgtvaehkfl slqkgpiskk ngiwfprgip dikhgrerst kqevklsdds 121 tvafsnnqke qskddvnrpv ipndritead rsndmksler qlsrtlyllv kdksgtwkfp 181 nfdlsdeskp lhvhaenelk llsgdqiytw svsatpigvl qdernrtaef ivkshilagk 241 fdlvasknda fedfawltkg eiseyvpkdy fnktefllad n // LOCUS NP_014148 575 aa linear PLN 30-JUN-2025 DEFINITION Nrd1 complex RNA-binding subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_014148 VERSION NP_014148.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183089.1 REFERENCE 1 (residues 1 to 575) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 575) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 575) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 575) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10308. Method: conceptual translation. FEATURES Location/Qualifiers source 1..575 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..575 /product="Nrd1 complex RNA-binding subunit" /calculated_mol_wt="63728" Region 8..149 /region_name="CID_Nrd1_like" /note="CID (CTD-Interacting Domain) of Nrd1 and similar proteins; cd16984" /db_xref="CDD:340781" Site order(23..30,33,67,70..71,74..75,126..127,130..131) /site_type="other" /note="CTD binding site [polypeptide binding]" /db_xref="CDD:340781" Region 336..412 /region_name="RRM_NRD1_SEB1_like" /note="RNA recognition motif (RRM) found in Saccharomyces cerevisiae protein Nrd1, Schizosaccharomyces pombe Rpb7-binding protein seb1 and similar proteins; cd12331" /db_xref="CDD:409768" CDS 1..575 /gene="NRD1" /locus_tag="YNL251C" /coded_by="NM_001183089.1:1..1728" /experiment="EXISTENCE:direct assay:GO:0001068 transcription regulatory region RNA binding [PMID:21084293]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9618475]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0019904 protein domain specific binding [PMID:18660819]" /experiment="EXISTENCE:direct assay:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:16427013]" /experiment="EXISTENCE:direct assay:GO:0035649 Nrd1 complex [PMID:10655211]" /experiment="EXISTENCE:direct assay:GO:0071041 antisense RNA transcript catabolic process [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0034472 snRNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0042780 tRNA 3'-end processing [PMID:21460797]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:21113025]" /experiment="EXISTENCE:mutant phenotype:GO:0071034 CUT catabolic process [PMID:16973436]" /experiment="EXISTENCE:mutant phenotype:GO:0071041 antisense RNA transcript catabolic process [PMID:22028667]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27076633]" /note="RNA-binding subunit of Nrd1 complex; complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with CTD of RNA pol II large subunit Rpo21p at phosphorylated Ser5 to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; role in regulation of mitochondrial abundance and cell size" /db_xref="GeneID:855470" /db_xref="SGD:S000005195" ORIGIN 1 mqqdddfqnf vatlesfkdl ksgisgsrik klttyaldhi dieskiisli idysrlcpds 61 hklgslyiid sigrayldet rsnsnsssnk pgtcahaint lgeviqells daiaksnqdh 121 kekirmlldi wdrsglfqks ylnairskcf amdisnntan tasqqlsldp kqrskqilsn 181 lkkspplnln islptdltst dpakqqaalf qviaalqkhf ktlpshtsvg tvappqahti 241 teygsrrere rererynsrr nrsrsppapf sqpstgrkdr ypsvaqdqys igapnttfgt 301 nnhhlypdel nvsnnphyrp kpvsydstlp pdhikvysrt lfiggvplnm kewdlanvlk 361 pfaevqsvil nnsrkhafvk vysrheaenv lqnfnkdgal plrtrwgvgf gprdccdyqh 421 gysiipmhrl tdadkkwsvs aqwggtsgqp lvtgivfeep diivgegvss kaisqkmptd 481 sgrngprsgk pnksgsissi spvpygnapl aspppqqyvq pmmqqpygya pnqplpsqgp 541 aaaappvpqq qfdptaqlns lmnmlnqqqq qqqqs // LOCUS NP_014149 1312 aa linear PLN 30-JUN-2025 DEFINITION MRX complex DNA-binding subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_014149 VERSION NP_014149.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183088.1 REFERENCE 1 (residues 1 to 1312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1312) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10309. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1312 /product="MRX complex DNA-binding subunit" /calculated_mol_wt="152439" Region 2..1302 /region_name="rad50" /note="TIGR00606" /db_xref="CDD:129694" CDS 1..1312 /gene="RAD50" /locus_tag="YNL250W" /coded_by="NM_001183088.1:1..3939" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:8367302]" /experiment="EXISTENCE:direct assay:GO:0003691 double-stranded telomeric DNA binding [PMID:17698079]" /experiment="EXISTENCE:direct assay:GO:0004017 AMP kinase activity [PMID:17349953]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:9845372]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:15546877]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:15721260]" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17698079]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:17698079]" /experiment="EXISTENCE:mutant phenotype:GO:0000722 telomere maintenance via recombination [PMID:11238918]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:17349953]" /experiment="EXISTENCE:mutant phenotype:GO:0004017 AMP kinase activity [PMID:17349953]" /experiment="EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:20040573]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:31390569|PMID:9501103|PMID:12399380]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:8207053]" /experiment="EXISTENCE:mutant phenotype:GO:0035753 maintenance of DNA trinucleotide repeats [PMID:27173583]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:17349953]" /experiment="EXISTENCE:mutant phenotype:GO:0097552 mitochondrial double-strand break repair via homologous recombination [PMID:22214610]" /experiment="EXISTENCE:physical interaction:GO:0030870 Mre11 complex [PMID:9845372]" /note="Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:855471" /db_xref="SGD:S000005194" ORIGIN 1 msaiyklsiq girsfdsndr etiefgkplt livgmngsgk ttiieclkya ttgdlppnsk 61 ggvfihdpki tgekdiraqv klaftsangl nmivtrniql lmkkttttfk tlegqlvain 121 nsgdrstlst rsleldaqvp lylgvpkail eyvifchqed slwplsepsn lkkkfdeifq 181 amkftkaldn lksikkdmsv dikllkqsve hlkldkdrsk amklnihqlq tkidqyneev 241 seiesqlnei teksdklfks nqdfqkilsk venlkntkls isdqvkrlsn sidildlskp 301 dlqnllanfs kvlmdknnql rdletdissl kdrqsslqsl snslirrqge leagketyek 361 nrnhlsslke afqhkfqgls niensdmaqv nhemsqfkaf isqdltdtid qfakdiqlke 421 tnlsdliksi tvdsqnleyn kkdrsklihd seelaeklks fkslstqdsl nhelenlkty 481 keklqswese niipklnqki eeknnemiil enqiekfqdr imktnqqadl yaklglikks 541 intkldelqk iteklqndsr irqvfpltqe fqradlemdf qklfinmqkn iainnkkmhe 601 ldrrytnaly nlntiekdlq dnqkskekvi qllsenlped ctideyndvl eetelsykta 661 lenlkmhqtt lefnrkalei aerdsccylc srkfenesfk skllqelktk tdanfektlk 721 dtvqnekeyl hslrllekhi itlnsineki dnsqkcleka keetktsksk ldelevdstk 781 lkdekelaes eirpliekft ylekelkdle nssktiseel siyntsedgi qtvdelrdqq 841 rkmndslrel rktisdlqme kdekvrensr minlikekel tvseiesslt qkqniddsir 901 skrenindid srvkeleari islknkkdea qsvldkvkne rdiqvrnkqk tvadinrlid 961 rfqtiynevv dfeakgfdel qttikeleln kaqmlelkeq ldlksnevne ekrkladsnn 1021 eeknlkqnle lielksqlqh ieseisrldv qnaeaerdky qeeslrlrtr feklssenag 1081 klgemkqlqn qidslthqlr tdykdiekny hkewvelqtr sfvtddidvy skaldsaimk 1141 yhglkmqdin riidelwkrt ysgtdidtik irsdevsstv kgksynyrvv mykqdveldm 1201 rgrcsagqkv lasiiirlal setfgancgv ialdepttnl deenieslak slhniinmrr 1261 hqknfqlivi thdekflghm naaaftdhff kvkrddrqks qiewvdinrv ty // LOCUS NP_014150 542 aa linear PLN 30-JUN-2025 DEFINITION Mpa43p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014150 VERSION NP_014150.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183087.1 REFERENCE 1 (residues 1 to 542) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 542) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 542) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 542) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10310. Method: conceptual translation. FEATURES Location/Qualifiers source 1..542 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..542 /product="Mpa43p" /calculated_mol_wt="61536" Region 7..521 /region_name="ASKHA_ATPase-like" /note="ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; cl49607" /db_xref="CDD:483947" CDS 1..542 /gene="MPA43" /locus_tag="YNL249C" /coded_by="NM_001183087.1:1..1629" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /note="hypothetical protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:855472" /db_xref="SGD:S000005193" ORIGIN 1 mnsslqvgig idvgsssari gvynyyndal lemaqepvpy yqdsskkswk fwqksteiik 61 alqkclqkln ireyevkscg vsatcslaif erdrtsnmli pypnednvif wmdssavnec 121 qwlnmqcpqq lldylggkfv pemgvpklky fldeyshlrd khfhifdlhq yiayelsrly 181 ewniegllgr enlngigndg evsgwsssfy kniinlpsnv sigttslvan khisttvvrs 241 cidsyaswfa vasphletsl fmiagtsscy mygttisdtr ipgvwgpfdt ildnrgdfsv 301 yaagqsctgk liehlfeshp carkilkdga diyqvleqti rdieknngls ihiltkdmff 361 ygdyegnrtp fadprikgsf igestdtsml nltykyicil eflsfqtkli idtfqnensn 421 ihikelrisg sqaknerlls lislvnngva iikpkenvdm mgikgayvla ksakekkqla 481 dviterdisn dsekfeslae yrlgndsill rkllcvkyhi hldmakqqkr yhklvdevfq 541 hl // LOCUS NP_014151 415 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase I subunit RPA49 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014151 VERSION NP_014151.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183086.1 REFERENCE 1 (residues 1 to 415) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 415) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 415) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 415) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10311. Method: conceptual translation. FEATURES Location/Qualifiers source 1..415 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..415 /product="DNA-directed RNA polymerase I subunit RPA49" /calculated_mol_wt="46520" Region 33..404 /region_name="RNA_pol_I_A49" /note="A49-like RNA polymerase I associated factor; pfam06870" /db_xref="CDD:462024" CDS 1..415 /gene="RPA49" /locus_tag="YNL248C" /coded_by="NM_001183086.1:1..1248" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:21263028]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006362 transcription elongation by RNA polymerase I [PMID:18160037]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:9121426]" /experiment="EXISTENCE:mutant phenotype:GO:0005736 RNA polymerase I complex [PMID:1409638]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:12374750]" /note="RNA polymerase I subunit A49; essential for nucleolar assembly and for high polymerase loading rate; required for nucleolar localization of Rpa34p" /db_xref="GeneID:855473" /db_xref="SGD:S000005192" ORIGIN 1 msvkrsvsei eiesvqdqps vavgsffkgf rapsdttfdl ykkkksekde fvlhgenerl 61 eyegytdsss qasnqyvvgl fnpekksiql ykapvlvskv vskssknlrg pkiksksdtr 121 psalrnalge afgtkkakka iadlernrid sdkltdsaid ivdsvrtask dlptraqlde 181 itsndrptpl anidatdveq iypiesiipk kelqfirvss ilkeadkekk lelfpyqnns 241 kyvakkldsl tqpsqmtklq llyylslllg vyenrrvnnk tkllerlnsp peilvdgils 301 rftvikpgqf grskdrsyfi dpqnedkilc yilaiimhld nfiveitpla helnlkpskv 361 vslfrvlgai vkgatvaqae afgipkstaa sykiatmkvp fklpemtrrg rgprr // LOCUS NP_014152 767 aa linear PLN 30-JUN-2025 DEFINITION cysteine--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014152 VERSION NP_014152.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183085.1 REFERENCE 1 (residues 1 to 767) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 767) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 767) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 767) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10312. Method: conceptual translation. FEATURES Location/Qualifiers source 1..767 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..767 /product="cysteine--tRNA ligase" /EC_number="6.1.1.16" /calculated_mol_wt="87399" Region 2..762 /region_name="PTZ00399" /note="cysteinyl-tRNA-synthetase; Provisional" /db_xref="CDD:240402" CDS 1..767 /gene="CRS1" /locus_tag="YNL247W" /coded_by="NM_001183085.1:1..2304" /experiment="EXISTENCE:direct assay:GO:0004817 cysteine-tRNA ligase activity [PMID:9523015]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31350340]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:31350340]" /experiment="EXISTENCE:direct assay:GO:0006423 cysteinyl-tRNA aminoacylation [PMID:9523015]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Cysteinyl-tRNA synthetase; CRS1 has two in-frame start codons resulting in a shorter isoform that is retained in the cytosol and a longer form that is mitochondrial; may interact with ribosomes, based on co-purification experiments; human gene CARS allows growth of the yeast haploid null mutant after sporulation of a heterozygous diploid" /db_xref="GeneID:855474" /db_xref="SGD:S000005191" ORIGIN 1 mnifikalrr ytimstpkiv qpkwkvptpq aketvlklyn sltrskvefi pqsgnrgvtw 61 yscgptvyda shmgharnyv sidinrriiq dyfgydvqfv qnvtdiddki ilrarqnylf 121 dnfvkendtk fnatvvdkvk talfqyinkn ftiqgseikt ieefetwlsn adtetlklen 181 pkfpmhvtav qnaiesitkg dsmdaevafe kvkdvtvpll dkelgstisn peifrqlpay 241 weqkfnddml slnvlpptvt trvseyvpei idfvqkiidn gyayatsdgs vyfdtlkfdk 301 spnhdyakcq pwnkgqldli ndgegslsnf adngkksnnd falwkaskag epewespwgk 361 grpgwhiecs vmasdilgsn idihsggidl afphhdnela qsearfdnqq winyflhtgh 421 lhiegqkmsk slknfitiqe alkkfsprql rlafasvqwn nqldfkesli hevksfensm 481 nnffktiral kndaasaghi skkfspleke lladfveses kvhsafcdnl stpvalktls 541 elvtksntyi ttagaalkie pliaicsyit kilriigfps rpdnlgwaaq agsndgslgs 601 ledtvmpyvk clstfrddvr slaikkaepk eflqltdkir nedllnlnva lddrngqsal 661 ikfltndekl eivklneekh anelakkqkk leqqklreqk enerkqkaqi kpqdmfkdvt 721 lysawdeqgl ptkdkdgndi tksmtkklkk qweqqkklhe eyfgedk // LOCUS NP_014153 264 aa linear PLN 30-JUN-2025 DEFINITION Vps75p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014153 VERSION NP_014153.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183084.1 REFERENCE 1 (residues 1 to 264) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 264) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 264) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 264) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 264) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10313. Method: conceptual translation. FEATURES Location/Qualifiers source 1..264 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..264 /product="Vps75p" /calculated_mol_wt="30484" Region 20..183 /region_name="PTZ00007" /note="(NAP-L) nucleosome assembly protein -L; Provisional; cl08298" /db_xref="CDD:471807" CDS 1..264 /gene="VPS75" /locus_tag="YNL246W" /coded_by="NM_001183084.1:1..795" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:17344218]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006334 nucleosome assembly [PMID:17344218]" /experiment="EXISTENCE:direct assay:GO:0010698 acetyltransferase activator activity [PMID:19172749]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:17344218]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18036332]" /experiment="EXISTENCE:mutant phenotype:GO:0010698 acetyltransferase activator activity [PMID:19172749]" /experiment="EXISTENCE:physical interaction:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:18036332]" /experiment="EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:17344218]" /note="NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:855475" /db_xref="SGD:S000005190" ORIGIN 1 mmsdqenene hakaflglak ceeevdaier evelyrlnkm kpvyekrday ideiaefwki 61 vlsqhvsfan yirasdfkyi dtidkikvew lalesemydt rdfsitfhfh giegdfkeqq 121 vtkvfqikkg kddqedgilt sepvpiewpq sydsinpdli kdkrspegkk kyrqgmktif 181 gwfrwtglkp gkefphgdsl aslfseeiyp fcvkyyaeaq rdledeeges glsadgdsed 241 ddgslgevdl plsdeepssk krkv // LOCUS NP_014154 179 aa linear PLN 30-JUN-2025 DEFINITION U2-type spliceosomal complex subunit CWC25 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014154 VERSION NP_014154.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183083.1 REFERENCE 1 (residues 1 to 179) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 179) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 179) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 179) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 179) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10314. Method: conceptual translation. FEATURES Location/Qualifiers source 1..179 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..179 /product="U2-type spliceosomal complex subunit CWC25" /calculated_mol_wt="20243" Region 11..47 /region_name="Cir_N" /note="N-terminal domain of CBF1 interacting co-repressor CIR; pfam10197" /db_xref="CDD:462992" Region 74..153 /region_name="CWC25" /note="Pre-mRNA splicing factor; pfam12542" /db_xref="CDD:463626" CDS 1..179 /gene="CWC25" /locus_tag="YNL245C" /coded_by="NM_001183083.1:1..540" /experiment="EXISTENCE:direct assay:GO:0000398 mRNA splicing, via spliceosome [PMID:19935684]" /experiment="EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]" /note="Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p" /db_xref="GeneID:855476" /db_xref="SGD:S000005189" ORIGIN 1 mgsgdlnllk swnpklmknr kkvweteqdl iteqqklntr lkeiekerel nellnesskd 61 kpetlkndla lkksglewmy qdaklsdeke dyllgkkkld ssilnqpatp pvraattisa 121 sgaatsissq kkkskllkdd pmskfkvtkq qrrtpdstkk ramsqrgkpl skpapdldy // LOCUS NP_014155 108 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014155 VERSION NP_014155.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183082.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10315. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..108 /product="translation initiation factor eIF1" /calculated_mol_wt="12181" Region 2..108 /region_name="SUI1_MOF2" /note="translation initiation factor SUI1, eukaryotic; TIGR01160" /db_xref="CDD:130228" Site order(33,36..37,39,56,59..61,63..65,67,81,84) /site_type="other" /note="rRNA binding site [nucleotide binding]" /db_xref="CDD:211318" Site 83..84 /site_type="other" /note="Mutations affecting start-site selection" /db_xref="CDD:211318" CDS 1..108 /gene="SUI1" /locus_tag="YNL244C" /gene_synonym="MOF2; RFR1" /coded_by="NM_001183082.1:1..327" /experiment="EXISTENCE:direct assay:GO:0001731 formation of translation preinitiation complex [PMID:17434125|PMID:12008673|PMID:15664195|PMID:17504939]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:12861028|PMID:15145951]" /experiment="EXISTENCE:direct assay:GO:0043024 ribosomal small subunit binding [PMID:12860115|PMID:17434125|PMID:19751744]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:15838098|PMID:11018020]" /experiment="EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:19751744|PMID:17504939]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:19751744]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:9488467]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:15145951|PMID:22851688|PMID:12861028]" /note="Translation initiation factor eIF1; component of complex involved in recognition of initiator codon; modulates translation accuracy at initiation phase by discriminating against suboptimal initiation sites to prevent excessive uORF translation genome-wide" /db_xref="GeneID:855477" /db_xref="SGD:S000005188" ORIGIN 1 msienlksfd pfadtgddet atsnyihiri qqrngrktlt tvqgvpeeyd lkrilkvlkk 61 dfacngnivk dpemgeiiql qgdqrakvce fmisqlglqk knikihgf // LOCUS NP_014156 968 aa linear PLN 30-JUN-2025 DEFINITION Sla2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014156 VERSION NP_014156.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183081.2 REFERENCE 1 (residues 1 to 968) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 968) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 968) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 968) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 968) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 968) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 968) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 968) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10316. On Apr 26, 2011 this sequence version replaced NP_014156.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..968 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..968 /product="Sla2p" /calculated_mol_wt="108780" Region 7..269 /region_name="ANTH" /note="ANTH domain; pfam07651" /db_xref="CDD:400137" Site order(14,24,26..27) /site_type="other" /note="PtdIns(4,5)P2-binding site [chemical binding]" /db_xref="CDD:340804" Site order(21..26,29,32..33,36,69,73) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:340804" Region 420..>546 /region_name="DR0291" /note="Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only]; COG1579" /db_xref="CDD:441187" Region 763..965 /region_name="ILWEQ" /note="I/LWEQ domain; smart00307" /db_xref="CDD:214607" CDS 1..968 /gene="SLA2" /locus_tag="YNL243W" /gene_synonym="END4; MOP2" /coded_by="NM_001183081.2:1..2907" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:11302750]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10397764]" /experiment="EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:17151356]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:mutant phenotype:GO:0000147 actin cortical patch assembly [PMID:8335689]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8380177]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10397764]" /note="Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo" /db_xref="GeneID:855478" /db_xref="SGD:S000005187" ORIGIN 1 msridsdlqk alkkacsvee tapkrkhvra civytwdhqs skavfttlkt lplandevql 61 fkmlivlhki iqeghpsala eairdrdwir slgrvhsggs sysklireyv rylvlkldfh 121 ahhrgfnngt feyeeyvslv svsdpdegye tildlmslqd sldefsqiif asiqserrnt 181 eckisalipl iaesygiykf itsmlramhr qlndaegdaa lqplkeryel qharlfefya 241 dcssvkyltt lvtipklpvd apdvflindv deskeikfkk repsvtpart partptptpp 301 vvaepaispr pvsqrttstp tgylqtmptg attgmmipta tgaanaifpq ataqmqpdfw 361 anqqaqfane qnrleqervq qlqqqqaqqe lfqqqlqkaq qdmmnmqlqq qnqhqndlia 421 ltnqyekdqa llqqydqrvq qleseittmd staskqlank deqltalqdq ldvwerkyes 481 laklysqlrq ehlnllprfk klqlkvnsaq esiqkkeqle hklkqkdlqm aelvkdrdra 541 rlelersinn aeadsaaata aaetmtqdkm npildailes gintiqesvy nldsplswsg 601 pltpptflls llestsenat efatsfnnli vdglahgdqt evihcvsdfs tsmatlvtns 661 kayavttlpq eqsdqiltlv krcareaqyf fedlmsenln qvgdeektdi vinanvdmqe 721 klqelslaie pllniqsvks nketnphsel vatadkivks sehlrvdvpk pllslalmii 781 davvalvkaa iqcqneiatt tsiplnqfyl knsrwtegli saakavagat nvlittaskl 841 itsednents peqfivaske vaastiqlva asrvktsihs kaqdklehcs kdvtdacrsl 901 gnhvmgmied dhstsqqqqp ldftsehtlk taemeqqvei lkleqslsna rkrlgeirrh 961 ayynqddd // LOCUS NP_014157 1592 aa linear PLN 30-JUN-2025 DEFINITION Atg2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014157 VERSION NP_014157.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183080.1 REFERENCE 1 (residues 1 to 1592) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1592) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1592) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1592) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10317. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1592 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1592 /product="Atg2p" /calculated_mol_wt="178283" Region 784..921 /region_name="ATG2_CAD" /note="Autophagy-related protein 2 CAD motif; pfam13329" /db_xref="CDD:433120" Region 1489..1586 /region_name="ATG_C" /note="Autophagy-related protein C terminal domain; pfam09333" /db_xref="CDD:462761" CDS 1..1592 /gene="ATG2" /locus_tag="YNL242W" /gene_synonym="APG2; AUT8; SPO72" /coded_by="NM_001183080.1:1..4779" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569|PMID:11689437]" /experiment="EXISTENCE:direct assay:GO:0000425 pexophagy [PMID:11382760]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:11382760]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:27498190]" /experiment="EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:11382761]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:11382760]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:23382696]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:11382761]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]" /note="Putative lipid transport protein; peripheral membrane protein required for vesicle formation during autophagy, pexophagy and the CVT pathway; directed to autophagic membranes by Atg18p where it acts as a PAS-ER membrane tether during autophagosome formation; involved in Atg9p cycling between the PAS and mitochondria; binds the phospholipid PI(3)P via an APT1 domain; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:855479" /db_xref="SGD:S000005186" ORIGIN 1 mafwlpqniq krlllyvlqq islfsnidls nldvsigsks hfsfhdvnls lddlnipnvq 61 inegivdelv lkltvsggve idgsglrfim tplyssgsqe lhsdflvksi qdltnsmlqf 121 sdplttynry keddisssds ssdlnsniea skpaangsyt lqnmrnkaln valaklkial 181 kdvtirfivn drdpsdnive vhlesiqlit tdanlrhini enitissiqk qavpdspvhp 241 fnnddlsqsv ylskmeatsl ymsameeqsn edpsepqvtq eeqendkcke slmeinnlni 301 afkglssvnd lrmsnividi qdvhlaihki veiknstlkn iidiivthld anesfscqds 361 qspspdkqep salssvdikc iylnlgqdit vilksfkleq kennslafsl gsfysnsspl 421 tishktkpll tgeqtpqsia lnmgdeldii ishdgiahff kifqfvskcm sfyqnkskgm 481 mpqiasdtkr tvqltskavk lslkfpyfll cfqvspfiyd snrelyielv dvfkklpsrc 541 tkiltmssit isnlqsplql gsyddtlkea liyssvhaii kevifneeys givqlvedis 601 afgklftdsk nsectgksks krgsflqrsv rvlnssrfvy kqslsanfsl kidsmklkvs 661 eiigpqfgsv eallsnnffa itddsqivyf tknlkverkt psllepqeim svvlnkavne 721 pvlyvhrran gklkvifnni rihyyarwle ilkknigpdn asskdepvsq klskkqptsg 781 fpwelkcldc slilhpfrlk svmvivldnl ttggssfipq akllskantl fliddyqnfk 841 iqkdknwpsl infyagqgfs aigkidtlnf linksdgall ldckieqvgl slcadsfqtf 901 cqlcidlkyp qtfpdeekfr tqlknpidvf kdidcdlfns afirennhqn dydsvhlvds 961 fldkthefnn garsklssqg syemdsssgt atggillphe syldsaqpke edtppiaske 1021 qerdvdirgs idvekvvikl fdgydwkytr kfiantvekl dkelskaeas ssksnvpqse 1081 anifdsiyis anknnvtdlr rnldgeiqgv qnsfsdvskv nlrpskhyka liqlnkvhvn 1141 lknyrvdepd esnsdnstdv lnrcvvsiye feiidnvpts twnkfvtllk hepwphsspm 1201 flldlefirp idflqavelv mqlnvaplrl hvdqdtlefl irflgfkdkr felideypdi 1261 vfiqkfstns iklrldykpk kvdyaglrsg qtselmnfft ldgskiilks vvlyglngfd 1321 elnnklkaiw tpditkkqlp gvleglapvr sfmaigsgvk tlvtvlmsey rqeghlgrsl 1381 kkggnvflkt ttgdfvklgv kltsgtqail enteelfggv gsngrvydas kfgsadgads 1441 dtaavldldt lfeedqlvgs kysrirdhep tavvidmssp gdhneptivs lyadqpldlp 1501 tglkeayssl ekhmhiayda vwrakgqmkd dkrggpsaaa vyvaraapva iirpligate 1561 avsktlqgia nqvdkthneq indkyksnrt ds // LOCUS NP_014158 505 aa linear PLN 30-JUN-2025 DEFINITION glucose-6-phosphate dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014158 VERSION NP_014158.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183079.1 REFERENCE 1 (residues 1 to 505) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 505) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 505) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 505) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 505) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10318. Method: conceptual translation. FEATURES Location/Qualifiers source 1..505 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..505 /product="glucose-6-phosphate dehydrogenase" /EC_number="1.1.1.49" /calculated_mol_wt="57391" Region 10..489 /region_name="zwf" /note="glucose-6-phosphate 1-dehydrogenase; TIGR00871" /db_xref="CDD:273312" CDS 1..505 /gene="ZWF1" /locus_tag="YNL241C" /gene_synonym="MET19; POS10" /coded_by="NM_001183079.1:1..1518" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004345 glucose-6-phosphate dehydrogenase activity [PMID:2269430|PMID:2001672]" /experiment="EXISTENCE:mutant phenotype:GO:0006740 NADPH regeneration [PMID:2269430]" /experiment="EXISTENCE:mutant phenotype:GO:0009051 pentose-phosphate shunt, oxidative branch [PMID:8299150|PMID:7045591]" /experiment="EXISTENCE:mutant phenotype:GO:0042542 response to hydrogen peroxide [PMID:7586028|PMID:9480895]" /note="Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adaptation to oxidative stress; negative regulator of nonselective autophagy, independent of Stb5p; protein abundance increases in response to DNA replication stress; homolog of human G6PD which is deficient in patients with hemolytic anemia; human G6PD can complement yeast zwf1 null mutant" /db_xref="GeneID:855480" /db_xref="SGD:S000005185" ORIGIN 1 msegpvkfek ntvisvfgas gdlakkktfp alfglfregy ldpstkifgy arsklsmeed 61 lksrvlphlk kphgeaddsk veqffkmvsy isgnydtdeg fdelrtqiek feksanvdvp 121 hrlfylalpp svfltvakqi ksrvyaengi trvivekpfg hdlasarelq knlgplfkee 181 elyridhylg kelvknllvl rfgnqflnas wnrdniqsvq isfkerfgte grggyfdsig 241 iirdvmqnhl lqimtlltme rpvsfdpesi rdekvkvlka vapidtddvl lgqygksedg 301 skpayvdddt vdkdskcvtf aamtfniene rwegvpimmr agkalneskv eirlqykava 361 sgvfkdipnn elvirvqpda avylkfnakt pglsnatqvt dlnltyasry qdfwipeaye 421 vlirdallgd hsnfvrddel diswgiftpl lkhierpdgp tpeiypygsr gpkglkeymq 481 khkyvmpekh pyawpvtkpe dtkdn // LOCUS NP_014159 491 aa linear PLN 30-JUN-2025 DEFINITION iron-sulfur cluster assembly protein NAR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014159 VERSION NP_014159.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183078.1 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10319. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..491 /product="iron-sulfur cluster assembly protein NAR1" /calculated_mol_wt="54020" Region 95..420 /region_name="Fe_hyd_lg_C" /note="Iron only hydrogenase large subunit, C-terminal domain; pfam02906" /db_xref="CDD:397172" CDS 1..491 /gene="NAR1" /locus_tag="YNL240C" /coded_by="NM_001183078.1:1..1476" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15103330]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15103330]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:15103330]" /note="Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery; required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; deficiency results in shortened lifespan and sensitivity to paraquat; homologous to human Narf" /db_xref="GeneID:855481" /db_xref="SGD:S000005184" ORIGIN 1 msallsesdl ndfispalac vkptqvsggk kdnvnmngey evstepdqle kvsitlsdcl 61 acsgcitsse eillssqshs vflknwgkls qqqdkflvvs vspqcrlsla qyygltleaa 121 dlclmnffqk hfqckymvgt emgriisisk tvekiiahkk qkentgadrk pllsavcpgf 181 liytektkpq lvpmllnvks pqqitgslir atfeslaiar esfyhlslmp cfdkkleasr 241 peslddgidc vitpreivtm lqelnldfks fltedtslyg rlsppgwdpr vhwasnlggt 301 cggyayqyvt avqrlhpgsq mivlegrnsd iveyrllhdd riiaaasels gfrniqnlvr 361 kltsgsgser krnitalrkr rtgpkansre maaataatad pyhsdyievn acpgacmngg 421 gllngeqnsl krkqlvqtln krhgeelamv dpltlgpkle eaaarplsle yvfapvkqav 481 ekdlvsvgst w // LOCUS NP_014160 454 aa linear PLN 30-JUN-2025 DEFINITION bleomycin hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014160 VERSION NP_014160.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183077.1 REFERENCE 1 (residues 1 to 454) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 454) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 454) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 454) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10320. On Jan 21, 2003 this sequence version replaced NP_014160.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..454 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..454 /product="bleomycin hydrolase" /EC_number="3.4.22.40" /calculated_mol_wt="51958" Region 4..450 /region_name="Peptidase_C1_2" /note="Peptidase C1-like family; pfam03051" /db_xref="CDD:397262" Site order(42,50,52..54,165..166,236,238,240,246,387) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:238328" Site order(67,73,369,392) /site_type="active" /db_xref="CDD:238328" Site 450 /site_type="active" /note="G bulge [active]" /db_xref="CDD:238328" CDS 1..454 /gene="LAP3" /locus_tag="YNL239W" /gene_synonym="BLH1; GAL6; YCP1" /coded_by="NM_001183077.1:1..1365" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8063738]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:9584198]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:9584198]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:19061865|PMID:9584198|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0008234 cysteine-type peptidase activity [PMID:8063738]" /experiment="EXISTENCE:direct assay:GO:0043418 homocysteine catabolic process [PMID:16769724]" /experiment="EXISTENCE:direct assay:GO:0046677 response to antibiotic [PMID:8063738]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9374524]" /experiment="EXISTENCE:mutant phenotype:GO:0043418 homocysteine catabolic process [PMID:16769724]" /note="Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; cytosolic protein, selectively transported to vacuole during nitrogen starvation; targeted to vacuole via CVT pathway; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH" /db_xref="GeneID:855482" /db_xref="SGD:S000005183" ORIGIN 1 msssidiski nswnkefqsd lthqlattvl knynaddall nktrlqkqdn rvfntvvstd 61 stpvtnqkss grcwlfaatn qlrlnvlsel nlkefelsqa ylffydklek anyfldqivs 121 sadqdidsrl vqyllaapte dggqysmfln lvkkyglipk dlygdlpyst tasrkwnsll 181 ttklrefaet lrtalkersa ddsiivtlre qmqreifrlm slfmdippvq pneqftweyv 241 dkdkkihtik stplefasky akldpstpvs lindprhpyg klikidrlgn vlggdaviyl 301 nvdnetlskl vvkrlqnnka vffgshtpkf mdkktgvmdi elwnypaigy nlpqqkasri 361 ryheslmtha mlitgchvde tsklplryrv enswgkdsgk dglyvmtqky feeycfqivv 421 dinelpkela skftsgkeep ivlpiwdpmg alak // LOCUS NP_014161 814 aa linear PLN 30-JUN-2025 DEFINITION kexin KEX2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014161 VERSION NP_014161.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183076.1 REFERENCE 1 (residues 1 to 814) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 814) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 814) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 814) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 814) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 814) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 814) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 814) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10321. Method: conceptual translation. FEATURES Location/Qualifiers source 1..814 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..814 /product="kexin KEX2" /EC_number="3.4.21.61" /calculated_mol_wt="89872" Region 133..419 /region_name="Peptidases_S8_Protein_convertases_Kexins_Fur in-lik" /note="Peptidase S8 family domain in Protein convertases; cd04059" /db_xref="CDD:173789" Site order(135,184,227) /site_type="other" /note="calcium binding site 1 [ion binding]" /db_xref="CDD:173789" Site order(175..176,210,213,255,273,283,314,325,385) /site_type="active" /db_xref="CDD:173789" Site order(175,213,385) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:173789" Site order(320,350) /site_type="other" /note="calcium binding site 2 [ion binding]" /db_xref="CDD:173789" Site order(328,330,333,335) /site_type="other" /note="calcium binding site 3 [ion binding]" /db_xref="CDD:173789" Region 505..590 /region_name="P_proprotein" /note="Proprotein convertase P-domain; pfam01483" /db_xref="CDD:460225" CDS 1..814 /gene="KEX2" /locus_tag="YNL238W" /gene_synonym="QDS1; SRB1; VMA45" /coded_by="NM_001183076.1:1..2445" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004252 serine-type endopeptidase activity [PMID:2646633]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:8308064]" /experiment="EXISTENCE:mutant phenotype:GO:0007323 peptide pheromone maturation [PMID:6430565]" /note="Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway" /db_xref="GeneID:855483" /db_xref="SGD:S000005182" ORIGIN 1 mkvrkyitlc fwwafstsal vssqqiplkd htsrqyfave snetlsrlee mhpnwkyehd 61 vrglpnhyvf skellklgkr ssleelqgdn ndhilsvhdl fprndlfkrl pvpappmdss 121 llpvkeaedk lsindplfer qwhlvnpsfp gsdinvldlw ynnitgagvv aaivddgldy 181 enedlkdnfc aegswdfndn tnlpkprlsd dyhgtrcage iaakkgnnfc gvgvgynaki 241 sgirilsgdi ttedeaasli ygldvndiys cswgpaddgr hlqgpsdlvk kalvkgvteg 301 rdskgaiyvf asgnggtrgd ncnydgytns iysitigaid hkdlhppyse gcsavmavty 361 ssgsgeyihs sdingrcsns hggtsaaapl aagvytllle anpnltwrdv qylsilsavg 421 leknadgdwr dsamgkkysh rygfgkidah kliemsktwe nvnaqtwfyl ptlyvsqstn 481 steetlesvi tisekslqda nfkriehvtv tvdidteirg tttvdlispa giisnlgvvr 541 prdvssegfk dwtfmsvahw gengvgdwki kvkttenghr idfhswrlkl fgesidsskt 601 etfvfgndke evepaatest vsqysassts isisatstss isigvetsai pqtttastdp 661 dsdpntpkkl ssprqamhyf ltifligatf lvlyfmffmk srrrirrsra etyefdiidt 721 dseydstldn gtsgitepee vedfdfdlsd edhlaslsss engdaehtid svltnenpfs 781 dpikqkfpnd anaesasnkl qelqpdvpps sgrs // LOCUS NP_014162 459 aa linear PLN 30-JUN-2025 DEFINITION Ytp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014162 VERSION NP_014162.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183075.1 REFERENCE 1 (residues 1 to 459) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 459) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 459) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 459) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10322. Method: conceptual translation. FEATURES Location/Qualifiers source 1..459 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..459 /product="Ytp1p" /calculated_mol_wt="51513" Region 176..413 /region_name="Ytp1" /note="Protein of unknown function (Ytp1); pfam10355" /db_xref="CDD:431228" CDS 1..459 /gene="YTP1" /locus_tag="YNL237W" /coded_by="NM_001183075.1:1..1380" /note="Probable type-III integral membrane hypothetical protein; has regions of similarity to mitochondrial electron transport proteins" /db_xref="GeneID:855484" /db_xref="SGD:S000005181" ORIGIN 1 mtaanknivf gfsrsisail licfffekvc gdmehdmgmd dtsgytrpei vqagsksfhw 61 lctlgfllll psvvtclsfa griysatllq ctcavyafle aavlrfqdnd gvenrtsrgt 121 awflvgltwi tlffgglagg tgflvkskrl qtfisnagek rlsyihrgls fltvltgwvk 181 vclapvalfg fcreahtgqc iahgimgsaf vlygfiyvlv lvipwirsaq tsysqdyvds 241 wvmciwgvvn tftehrwgre gwsvhdyqht fmgiiwwtgg ilgiflsrng rrtfvpslii 301 iftgwamseh aqhliistkv hnmfglvlmc ggalriieis fllrdkrtld kihsfqylap 361 fclvcsgllf mganeeqlil vlrlggdhsa yvliivsgaf lvyfwmiacl efylyllekg 421 kqgflpksye leeennnvsf eldnisnedv dedttpfnv // LOCUS NP_014163 974 aa linear PLN 30-JUN-2025 DEFINITION Sin4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014163 VERSION NP_014163.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183074.1 REFERENCE 1 (residues 1 to 974) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 974) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 974) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 974) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 974) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 974) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 974) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 974) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10323. Method: conceptual translation. FEATURES Location/Qualifiers source 1..974 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..974 /product="Sin4p" /calculated_mol_wt="111166" Region 178..971 /region_name="Med16" /note="Mediator complex subunit 16; pfam11635" /db_xref="CDD:371639" CDS 1..974 /gene="SIN4" /locus_tag="YNL236W" /gene_synonym="BEL2; GAL22; MED16; RYE1; SDI3; SSF5; SSN4; SSX3; TSF3" /coded_by="NM_001183074.1:1..2925" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:9891034]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20308326]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:genetic interaction:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12558798]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:12482986]" /experiment="EXISTENCE:mutant phenotype:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both positive and negative transcriptional regulation; dispensible for basal transcription" /db_xref="GeneID:855485" /db_xref="SGD:S000005180" ORIGIN 1 mmlgehlmsw sktgiiaysd sqssnanicl tflesingin wrfhtpqkyv lhpqlhevqy 61 qessstlsth stttsvngst tagvgstpnf ggnsnksppq ffynissihw nnwfslpgdm 121 lavcdelgnm tmlitgqrpd rattyekltm vfqdnvykiy nhvmplkpvd klkpmnierk 181 qtrkeyntsi lefrwltssk svivsqfcaf dsssntyrsr aqqvppygvy hppfikyacl 241 airkngqidf wyqfsnskdh kkitlqlldt snqrfkdlqw lefaritpmn ddqcmlitty 301 sklsknisfy klhvnwnlna tkpnvlndps lkiqfilstt ldptddeghv lklenlhvvs 361 kssiekdpsp eilvlynvcd tskslvkryr laptqlsaey lvilkpdlni drnnstnqif 421 qsrrynlrrh sdivldkkvt litsemfdaf vsfyfedgti esynqndwkl eterlisqsq 481 lgkfkniias plsagfnygk lplppsvewm kvspsmcgvi vkqynkkwpq fyaavqknya 541 dpekdsinat alafgyvksl hkqisaedlt iaakthilri sfldrkrake fittllksly 601 sffnispdap keimdkiits rplqkimllq lelgscfsqe nieemarvil ylknvlfafn 661 gvarnfhfai eqisnnsnqq qnpklfqtif skqdlihsli pvakwfvkfi tyltqeilil 721 indptnkeyt lvhgifgakm srtlilsiln eikkvtqiva kfpetsypil nesstflklv 781 lsespvdfek fetflvdvnn kfialceqqp sqerefsllv kaeippeyak vgdfllqyan 841 navishanaa avyfadtsgl kisnseffnp eifhllqple egliidtdkl piknrtsksf 901 skllyddvtc dklsvseisd gklkrcsrcg svtragniis sdktivptsi qtkrwptmyt 961 rlcicsgmlf emdg // LOCUS NP_014165 426 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL234W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014165 VERSION NP_014165.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183072.1 REFERENCE 1 (residues 1 to 426) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 426) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 426) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 426) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 426) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10324. Method: conceptual translation. FEATURES Location/Qualifiers source 1..426 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..426 /product="uncharacterized protein" /calculated_mol_wt="47692" Region 178..293 /region_name="Mb-like" /note="myoglobin-like; M family globin domain; cd01040" /db_xref="CDD:381254" Site order(205..206,212,215..216,219,240,243..244,250,254..255, 258) /site_type="other" /note="heme binding site [chemical binding]" /db_xref="CDD:381254" CDS 1..426 /locus_tag="YNL234W" /coded_by="NM_001183072.1:1..1281" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0020037 heme binding [PMID:9988749]" /note="hypothetical protein with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1" /db_xref="GeneID:855487" /db_xref="SGD:S000005178" ORIGIN 1 mtgekilhsq lltnsdmssg nvhhtkpmmy nvtlpsynss sigpvdnlki nerpgshdhs 61 mrsemsskns gsdfmpqsis rsegsvyqvk idrgdspnte gfdfkvnard llllrmswdi 121 llreyltpke lkvfqallys nkhitsterp ylntapdgmi sktidptarp rktkqrdndn 181 kvdtalfcsq fydnliamdp lleeyfpslk hqavsfckvl dsaidnlenv hvlddyivkl 241 gkrhsrilgi ktvgfevmgk afmttlqdrf gsfltlelkn lwgqlysyla ncmitagkdp 301 mekiqpdfsy ngdsvvlnfs ipklamhdis tvnklqmvkt knatiphnit qvptnkipte 361 illdnsstpi ksdrestppi spkgsgstkp sigsstvves ntkknnydek ihllqktaqq 421 kncsim // LOCUS NP_014166 892 aa linear PLN 30-JUN-2025 DEFINITION Bni4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014166 VERSION NP_014166.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183071.1 REFERENCE 1 (residues 1 to 892) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 892) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 892) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 892) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 892) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 892) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 892) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 892) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10325. Method: conceptual translation. FEATURES Location/Qualifiers source 1..892 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..892 /product="Bni4p" /calculated_mol_wt="100459" CDS 1..892 /gene="BNI4" /locus_tag="YNL233W" /coded_by="NM_001183071.1:1..2679" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15901837|PMID:15470103]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005940 septin ring [PMID:15901837|PMID:9314530]" /experiment="EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:15901837]" /experiment="EXISTENCE:mutant phenotype:GO:0000917 division septum assembly [PMID:15470103]" /experiment="EXISTENCE:mutant phenotype:GO:0006031 chitin biosynthetic process [PMID:15470103]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9314530|PMID:12529424]" /note="Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; phosphorylation by Slt2p and Kss1p involved in regulating Bni4p in septum assembly" /db_xref="GeneID:855488" /db_xref="SGD:S000005177" ORIGIN 1 msdsisdsks sellnstfys stsintldha rtfrnslilk eisdqslnss ikpcesvldr 61 dvessvlqrs fgesnardse vqtvnmttsp slsaladiln erskyadqkt rkaqniessi 121 ieeeeeaeeq nnsinyhedi tgsrlsvree anenlamtsp nlididgsns iqvaplslps 181 feepdflstp rvkpdsqgpr skvstrrtil erdnnlpvkr eentiinset estthsapfl 241 kedpkpspps sklynpkvrl nkaearkytd ssaqrttsag svledtsmhk kkksifsflk 301 kkepkpvign nsvtneknkm sssstfsmni qtslktpekl kkkshssssi fnsflkgkie 361 tsdsprkepm rqkkrtpksk dkkqdteqii daasvlstes pllrknhddt pvkidhvtrs 421 idqrkptpln mdlilggdkq intplqehvr edddakndlq lptkdnflsl dyeapspafs 481 khdtgevlfp kfldnhevds ivslertrst ksnkrssmns qrrsltdtls ikaqsegmfi 541 teassvvlst pdltkspass ilkngrfeys dnfsrehsye gttnedfldi kddsgplkkd 601 diflesieqk fdqlvmasde ekteverdvp kpreeplkkd serqsvfadd dnelisdime 661 fasfinfgdd dlnldldlgd ttasyatetp epvgndevnr sgtfdtrnnk edsykeretq 721 sysaagatty gderqgqlht feqdgseind nefenedfnk hieqpievtp rnnaylpefe 781 pnrpvsmsfk glkaprmnts fidsmtpdsp vksdltslge vyvnsnndqg vrfssqiily 841 dtygefeydr hpeistcnql tpqlaqmikl elnelksame vhddsrcyth fy // LOCUS NP_014167 292 aa linear PLN 30-JUN-2025 DEFINITION exosome non-catalytic core subunit CSL4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014167 VERSION NP_014167.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183070.1 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10326. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..292 /product="exosome non-catalytic core subunit CSL4" /calculated_mol_wt="31452" Region 9..287 /region_name="PRK09521" /note="exosome complex RNA-binding protein Csl4; Provisional" /db_xref="CDD:236547" Region 132..237 /region_name="EXOSC1" /note="Exosome component EXOSC1/CSL4; pfam10447" /db_xref="CDD:402191" Site order(144,152,162,164) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240217" Site order(146..148,150,156,221,226) /site_type="other" /note="subunit interface" /db_xref="CDD:240217" CDS 1..292 /gene="CSL4" /locus_tag="YNL232W" /gene_synonym="SKI4" /coded_by="NM_001183070.1:1..879" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:19046973|PMID:10465791]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11027292]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11027292]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15935758|PMID:17643380|PMID:15828860]" /experiment="EXISTENCE:genetic interaction:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:11027292|PMID:19060898]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10508172|PMID:10465791]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:19060898|PMID:11027292]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:27385342]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:11910110]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:10465791]" /note="Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; human homolog EXOSC1 partially complements yeast csl4 null mutant, and can complement inviability of strain in which expression of CSL4 is repressed" /db_xref="GeneID:855489" /db_xref="SGD:S000005176" ORIGIN 1 macnfqfpei aypgklicpq ygtenkdged iifnyvpgpg tkliqyehng rtleaitatl 61 vgtvrceeek ktdqeeereg tdqsteeeks vdaspndvtr rtvknilvsv lpgtekgrkt 121 nkyanndfan nlpkegdivl trvtrlslqr anveilaved kpspidsgig sngsgivaag 181 ggsgaatfsv sqassdlget frgiirsqdv rstdrdrvkv iecfkpgdiv raqvlslgdg 241 tnyylttarn dlgvvfaraa ngagglmyat dwqmmtspvt gatekrkcak pf // LOCUS NP_014168 351 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_014168 VERSION NP_014168.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183069.1 REFERENCE 1 (residues 1 to 351) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 351) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 351) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 351) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10327. Method: conceptual translation. FEATURES Location/Qualifiers source 1..351 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..351 /product="phosphatidylinositol transporter" /calculated_mol_wt="40583" Region 47..109 /region_name="CRAL_TRIO_N" /note="CRAL/TRIO, N-terminal domain; pfam03765" /db_xref="CDD:461043" Region 142..289 /region_name="CRAL_TRIO" /note="CRAL/TRIO domain; pfam00650" /db_xref="CDD:459890" CDS 1..351 /gene="PDR16" /locus_tag="YNL231C" /gene_synonym="SFH3" /coded_by="NM_001183069.1:1..1056" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:12869188|PMID:24403601]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0008526 phosphatidylinositol transfer activity [PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0015914 phospholipid transport [PMID:10848624]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:36482167|PMID:31690622]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:29187527]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:12869188]" /experiment="EXISTENCE:genetic interaction:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0008654 phospholipid biosynthetic process [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0009410 response to xenobiotic stimulus [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:9890948]" /experiment="EXISTENCE:genetic interaction:GO:0016126 sterol biosynthetic process [PMID:9890948]" /experiment="EXISTENCE:mutant phenotype:GO:0008526 phosphatidylinositol transfer activity [PMID:9890948]" /experiment="EXISTENCE:mutant phenotype:GO:0015914 phospholipid transport [PMID:9890948]" /experiment="EXISTENCE:mutant phenotype:GO:0043942 negative regulation of sexual sporulation resulting in formation of a cellular spore [PMID:24403601]" /note="Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855490" /db_xref="SGD:S000005175" ORIGIN 1 mfkrfskkke apedpknlin idkpikelpa siaipkekpl tgeqqkmyde vlkhfsnpdl 61 kvytseknks eddlkpleee ekawltrecf lrylratkwv lkdcidritm tlawrrefgi 121 shlgeehgdk itadlvaven esgkqvilgy endarpilyl kpgrqntkts hrqvqhlvfm 181 lervidfmpa gqdslallid fkdypdvpkv pgnskippig vgkevlhilq thyperlgka 241 lltnipwlaw tflklihpfi dpltreklvf depfvkyvpk neldslyggd lkfkynhdvy 301 wpalvetare krdhyfkrfq sfggivglse vdlrgthekl lypvksesst v // LOCUS NP_014169 379 aa linear PLN 30-JUN-2025 DEFINITION elongin A [Saccharomyces cerevisiae S288C]. ACCESSION NP_014169 VERSION NP_014169.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183068.1 REFERENCE 1 (residues 1 to 379) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 379) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 379) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 379) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 379) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10328. Method: conceptual translation. FEATURES Location/Qualifiers source 1..379 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..379 /product="elongin A" /calculated_mol_wt="43850" Region 19..165 /region_name="Elongin_A" /note="RNA polymerase II transcription factor SIII (Elongin) subunit A; pfam06881" /db_xref="CDD:462026" CDS 1..379 /gene="ELA1" /locus_tag="YNL230C" /coded_by="NM_001183068.1:1..1140" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:17296727]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:17296727]" /experiment="EXISTENCE:mutant phenotype:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:17296727]" /experiment="EXISTENCE:physical interaction:GO:0070449 elongin complex [PMID:10753924|PMID:10430890]" /note="Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex" /db_xref="GeneID:855491" /db_xref="SGD:S000005174" ORIGIN 1 mkslqtlcei slmrnhsniq svsnvpyhll krilqkvkip qllkleksnv llifdddelw 61 leflrqdfpt nvheqfvskr diickyyfdf vkendielyh snqdllkscv rqsvvkdirn 121 nkyripyrml yskyqqevek kqeesaerlr lemqklqqer ekkqtivvdh tvyfkkrntk 181 kttrlhneph sqlymkslkd hesrlkhfkd ggfniakrha qrvafggqag gqssspkkgp 241 lsikpepvkv nrqmdnvtae kkdvtqpitp vkkrrsesps iflnrkkpal frptpktnaa 301 gsrphttait ndhrttshpy phkdvvtsis svtanpvtkg hkkkksgifv rnagsdgdsf 361 phvtatgptt rpyiyeprk // LOCUS NP_014170 354 aa linear PLN 30-JUN-2025 DEFINITION glutathione peroxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014170 VERSION NP_014170.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183067.1 REFERENCE 1 (residues 1 to 354) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 354) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 354) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 354) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10329. Method: conceptual translation. FEATURES Location/Qualifiers source 1..354 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..354 /product="glutathione peroxidase" /EC_number="1.11.1.9" /calculated_mol_wt="40140" Region 114..194 /region_name="GST_N_Ure2p_like" /note="GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; cd03048" /db_xref="CDD:239346" Site order(123..124,127,130,133..134,186) /site_type="other" /note="C-terminal domain interface [polypeptide binding]" /db_xref="CDD:239346" Site order(124,164..166,180..181) /site_type="other" /note="GSH binding site (G-site) [chemical binding]" /db_xref="CDD:239346" Site order(161..162,164,177,179..180,183) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:239346" Region 208..350 /region_name="GST_C_Ure2p" /note="C-terminal, alpha helical domain of fungal Ure2p Glutathione S-transferases; cd10293" /db_xref="CDD:198326" Site order(210..211,214..215,217..218,220..221,229,232..233,241, 243,247..248,254,258) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:198326" Site order(213,219..220,312,315..316,344,346,349) /site_type="other" /note="N-terminal domain interface [polypeptide binding]" /db_xref="CDD:198326" CDS 1..354 /gene="URE2" /locus_tag="YNL229C" /coded_by="NM_001183067.1:1..1065" /experiment="EXISTENCE:direct assay:GO:0004602 glutathione peroxidase activity [PMID:15371425]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10748041]" /experiment="EXISTENCE:direct assay:GO:0051219 phosphoprotein binding [PMID:10604478]" /experiment="EXISTENCE:genetic interaction:GO:0006808 regulation of nitrogen utilization [PMID:8755910]" /experiment="EXISTENCE:mutant phenotype:GO:0006808 regulation of nitrogen utilization [PMID:8002570]" /experiment="EXISTENCE:mutant phenotype:GO:0010621 negative regulation of transcription by transcription factor localization [PMID:10799523|PMID:10748041]" /experiment="EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14551258]" /experiment="EXISTENCE:physical interaction:GO:0006808 regulation of nitrogen utilization [PMID:8755910]" /note="Nitrogen catabolite repression transcriptional regulator; inhibits GLN3 transcription in good nitrogen source; role in sequestering Gln3p and Gat1p to the cytoplasm; has glutathione peroxidase activity and can mutate to acquire GST activity; self-assembly under limited nitrogen conditions creates [URE3] prion and releases catabolite repression" /db_xref="GeneID:855492" /db_xref="SGD:S000005173" ORIGIN 1 mmnnngnqvs nlsnalrqvn ignrnsnttt dqsninfefs tgvnnnnnnn sssnnnnvqn 61 nnsgrngsqn ndnenniknt leqhrqqqqa fsdmshveys ritkffqeqp legytlfshr 121 sapngfkvai vlselgfhyn tifldfnlge hrapefvsvn pnarvpalid hgmdnlsiwe 181 sgaillhlvn kyyketgnpl lwsddladqs qinawlffqt sghapmigqa lhfryfhsqk 241 iasaverytd evrrvygvve malaerreal vmeldtenaa aysagttpms qsrffdypvw 301 lvgdkltiad lafvpwnnvv driginikie fpevykwtkh mmrrpavika lrge // LOCUS NP_014172 590 aa linear PLN 30-JUN-2025 DEFINITION Jjj1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014172 VERSION NP_014172.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183065.1 REFERENCE 1 (residues 1 to 590) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 590) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 590) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 590) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10330. Method: conceptual translation. FEATURES Location/Qualifiers source 1..590 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..590 /product="Jjj1p" /calculated_mol_wt="68652" Region 1..>67 /region_name="PRK10767" /note="chaperone protein DnaJ; Provisional" /db_xref="CDD:236757" Region 6..>275 /region_name="ZUO1" /note="Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]; COG5269" /db_xref="CDD:227594" Region 338..363 /region_name="zf-C2H2_jaz" /note="Zinc-finger double-stranded RNA-binding; pfam12171" /db_xref="CDD:432381" Region 340..362 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275371" Region 551..573 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275371" CDS 1..590 /gene="JJJ1" /locus_tag="YNL227C" /coded_by="NM_001183065.1:1..1773" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:17242366]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20368619|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:17242366]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0005730 nucleolus [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:20368619]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:17242366]" /note="Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis" /db_xref="GeneID:855495" /db_xref="SGD:S000005171" ORIGIN 1 mktcyyellg vethasdlel kkayrkkalq yhpdknpdnv eeatqkfavi raayevlsdp 61 qerawydshk eqilndtpps tddyydyevd atvtgvttde lllffnsaly tkidnsaagi 121 yqiagkifak lakdeilsgk rlgkfseyqd dvfeqdinsi gylkacdnfi nktdkllypl 181 fgysptdyey lkhfyktwsa fntlksfswk deymysknyd rrtkrevnrr nekarqqarn 241 eynktvkrfv vfikkldkrm kegakiaeeq rklkeqqrkn elnnrrkfgn dnndeekfhl 301 qswqtvkeen wdelekvydn fgefensknd kegevliyec ficnktfkse kqlknhintk 361 lhkknmeeir kemeeenitl gldnlsdlek fdsadesvke kedidlqalq aelaeierkl 421 aesssedese ddnlniemdi evedvssden vhvntknkkk rkkkkkakvd teteesesfd 481 dtkdkrsnel ddllaslgdk glqtdddedw stkakkkkgk qpkknskstk stpslstlps 541 smsptsaiev cttcgesfds rnklfnhvki aghaavknvv krkkvktkri // LOCUS NP_014174 581 aa linear PLN 30-JUN-2025 DEFINITION Cnm67p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014174 VERSION NP_014174.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183063.1 REFERENCE 1 (residues 1 to 581) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 581) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 581) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 581) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 581) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10331. Method: conceptual translation. FEATURES Location/Qualifiers source 1..581 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..581 /product="Cnm67p" /calculated_mol_wt="67269" Region <175..>439 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 444..575 /region_name="SID" /note="Septation initiation; pfam11778" /db_xref="CDD:403090" CDS 1..581 /gene="CNM67" /locus_tag="YNL225C" /coded_by="NM_001183063.1:1..1746" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:11514632]" /experiment="EXISTENCE:direct assay:GO:0061499 outer plaque of mitotic spindle pole body [PMID:9585415]" /experiment="EXISTENCE:mutant phenotype:GO:0005200 structural constituent of cytoskeleton [PMID:11514632]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:9571234|PMID:10749924]" /experiment="EXISTENCE:mutant phenotype:GO:0051300 spindle pole body organization [PMID:9571234]" /note="Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication" /db_xref="GeneID:855496" /db_xref="SGD:S000005169" ORIGIN 1 mtdfdlmnfp fherldspvs engeikdgep ipqnwlnenh vgksilplfv npedvincnf 61 snardsyeen kspsmdqmny arntsyqesp glqerpknek dkspigtdvh kkdvpnfihs 121 tprensskhf traneqasaq ptdehtspdi siedcngaki flqnslsked frmlenvilg 181 yqkkvielgr dnlrqeeran slqkeleaat ksndktldnk kkieeqtvli enltkdlsln 241 kemlekandt iqtkhtalls ltdslrkael feipigilff dlydseenss kldhilqeky 301 pnikgflcas qqeelsrisq rfknakaeae dlrnelenkk ieiqtmrekn ntligtnktl 361 skqnkilcdk fdkltideke ilkgcneeik iklerlnerl gswekskeky etslkdkekm 421 ladaekktnt lskeldnlrs rfgnlegnts eritiknilq srpdisaeec nflmveqids 481 anlttlqntv keivlavgip ypklrrkipl laiklkyeni mlsnfaqrlh rqvysqemnl 541 kkftdqayyd fmstrrmdsi dhhlercldh lydhilekmv k // LOCUS NP_014175 767 aa linear PLN 30-JUN-2025 DEFINITION Sqs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014175 VERSION NP_014175.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183062.1 REFERENCE 1 (residues 1 to 767) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 767) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 767) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 767) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 767) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10332. Method: conceptual translation. FEATURES Location/Qualifiers source 1..767 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..767 /product="Sqs1p" /calculated_mol_wt="86819" Region 597..654 /region_name="R3H_G-patch" /note="R3H domain of a group of fungal and plant proteins with unknown function, who also contain a G-patch domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the R3H...; cd02646" /db_xref="CDD:100075" Site order(625,629) /site_type="other" /note="RxxxH motif" /db_xref="CDD:100075" Region 721..764 /region_name="G-patch" /note="G-patch domain; pfam01585" /db_xref="CDD:396249" CDS 1..767 /gene="SQS1" /locus_tag="YNL224C" /gene_synonym="PFA1" /coded_by="NM_001183062.1:1..2304" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:19927118]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:19927118]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:19927118]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:19927118|PMID:16227579]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16945917]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:19927118]" /experiment="EXISTENCE:genetic interaction:GO:0030490 maturation of SSU-rRNA [PMID:19927118|PMID:19801658]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:19927118]" /note="Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress" /db_xref="GeneID:855497" /db_xref="SGD:S000005168" ORIGIN 1 makrhshyqg srrrhargsn skkagrgnak giqgrkikkk ptptnswhns siplgegdld 61 dvgadfnpgr afispktied yyfgrdaksr smkmgglrpg nrydsstdlq agraafrkrp 121 mqfvkakevy dpshnmiqkl raknetknse eivereadvf eepgkmtsdv eyinnedsen 181 edddsqnsps tdhslssnes kvedgdlffv deeaqqspdl tkikrvciee iarprevaie 241 fdpiltigkv elsvsegnes keisvdvpnk gnktyhpfag yisnvlhgmh tsdsdndeld 301 yeietennse plyessasse vdqgfnyvgq rhnsradnnl lpspspqlte dikclsingt 361 ktfegnndnl pspaseelef gfkeedfvin tndivvsnir mggvdnsyyl rcyrllgdyd 421 fhwidqdllt dfvvdelglp edrlpaylnf iknslipkie paeptysdip isdssdegds 481 yegdsyedde dmassvvhsd ieeglddlia ytlkhdterf ktfetkslet kgkgkkkkll 541 iddalaldte tletlqskfs krietkakkr kakedfidqe nrnsndmlkk ypyglhiqni 601 kdefesflsr nndrltfppl dphgnktvmk iakhynmkss kigkanhtsv vvekikktkw 661 sspnyslidq lmrqrpvfmr idirrpreeq aafertktir gkfhvkegei vgqnapeign 721 enigrrmlek lgwksgeglg iqgnkgisep ifakikknrs glrhses // LOCUS NP_014176 494 aa linear PLN 30-JUN-2025 DEFINITION cysteine protease ATG4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014176 VERSION NP_014176.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183061.1 REFERENCE 1 (residues 1 to 494) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 494) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 494) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 494) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10333. On Oct 2, 2003 this sequence version replaced NP_014176.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..494 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..494 /product="cysteine protease ATG4" /calculated_mol_wt="55012" Region 84..371 /region_name="Peptidase_C54" /note="Peptidase family C54; pfam03416" /db_xref="CDD:460915" CDS 1..494 /gene="ATG4" /locus_tag="YNL223W" /gene_synonym="APG4; AUT2" /coded_by="NM_001183061.1:1..1485" /experiment="EXISTENCE:direct assay:GO:0004197 cysteine-type endopeptidase activity [PMID:11038174]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22240591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22240591]" /experiment="EXISTENCE:direct assay:GO:0019786 protein-phosphatidylethanolamide deconjugating activity [PMID:11038174]" /experiment="EXISTENCE:direct assay:GO:0051697 protein delipidation [PMID:17632063]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0004197 cysteine-type endopeptidase activity [PMID:11038174]" /experiment="EXISTENCE:mutant phenotype:GO:0006501 C-terminal protein lipidation [PMID:11038174]" /experiment="EXISTENCE:mutant phenotype:GO:0019786 protein-phosphatidylethanolamide deconjugating activity [PMID:11038174]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:11149920]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /note="Conserved cysteine protease required for autophagy; functions in both early and late stages of autophagosome formation; primes Atg8p by removing the C-terminal arginine residue of nascent Atg8p in preparation for conjugation with phosphatidylethanolamide (PE), and also cleaves the PE modified, membrane-bound form to reverse conjugation; regulates the membrane-binding state of Atg8p, that is required for autophagosome formation and autophagy, as well as the cytoplasm-to-vacuole targeting pathway" /db_xref="GeneID:855498" /db_xref="SGD:S000005167" ORIGIN 1 mqrwlqlwkm dlvqkvshgv fegsseepaa lmnhdyivlg evyperdees gaeqceqdcr 61 yrgeavsdgf lsslfgreis sytkeflldv qsrvnftyrt rfvpiarapd gpsplslnll 121 vrtnpistie dyianpdcfn tdigwgcmir tgqsllgnal qilhlgrdfr vngneslere 181 skfvnwfndt peapfslhnf vsagtelsdk rpgewfgpaa tarsiqsliy gfpecgiddc 241 ivsvssgdiy enevekvfae npnsrilfll gvklginavn esyresicgi lsstqsvgia 301 ggrpssslyf fgyqgneflh fdphipqpav edsfvescht skfgklqlse mdpsmligil 361 ikgekdwqqw klevaesaii nvlakrmddf dvscsmddve svssnsmkkd asnnenlgvl 421 egdyvdigai fphttntedv deydcfqdih ckkqkivvmg nthtvnanlt dyevegvlve 481 ketvgihspi dekc // LOCUS NP_014177 206 aa linear PLN 30-JUN-2025 DEFINITION RNA polymerase II subunit A C-terminal domain phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014177 VERSION NP_014177.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183060.1 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10334. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..206 /product="RNA polymerase II subunit A C-terminal domain phosphatase" /EC_number="3.1.3.16" /calculated_mol_wt="23338" Region 3..206 /region_name="SSU72" /note="RNA polymerase II-interacting protein involved in transcription start site selection [Transcription]; COG5211" /db_xref="CDD:227536" CDS 1..206 /gene="SSU72" /locus_tag="YNL222W" /coded_by="NM_001183060.1:1..621" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:22235117]" /experiment="EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:12660165]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity [PMID:22235117|PMID:15125841]" /experiment="EXISTENCE:genetic interaction:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:8657130]" /experiment="EXISTENCE:genetic interaction:GO:0004721 phosphoprotein phosphatase activity [PMID:12660165]" /experiment="EXISTENCE:genetic interaction:GO:0005634 nucleus [PMID:11046131]" /experiment="EXISTENCE:genetic interaction:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:11046131]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:17101794]" /experiment="EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:8657130]" /experiment="EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:22235117]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:17101794]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:12660165|PMID:22235117]" /experiment="EXISTENCE:mutant phenotype:GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity [PMID:22235117|PMID:15125841]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:12660165]" /experiment="EXISTENCE:mutant phenotype:GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled [PMID:12944462|PMID:12819204]" /experiment="EXISTENCE:mutant phenotype:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:12819204|PMID:12944462]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:12704082]" /experiment="EXISTENCE:mutant phenotype:GO:0031564 transcription antitermination [PMID:12453421]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:11046131]" /experiment="EXISTENCE:physical interaction:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12453421]" /experiment="EXISTENCE:physical interaction:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:11046131]" /note="Phosphatase and transcription/RNA-processing factor; associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 and serine-7 of the RNA polymerase II C-terminal domain; affects start site selection and transcriptional read through in vivo" /db_xref="GeneID:855499" /db_xref="SGD:S000005166" ORIGIN 1 mpshrnsnlk fctvcasnnn rsmeshkvlq eagynvssyg tgsavrlpgl sidkpnvysf 61 gtpyndiynd llsqsadryk sngllqmldr nrrlkkapek wqestkvfdf vftceercfd 121 avcedlmnrg gklnkivhvi nvdikddden akigskaile ladmlndkie qcekddipfe 181 dcimdiltew qsshsqlpsl yapsyy // LOCUS NP_014178 875 aa linear PLN 30-JUN-2025 DEFINITION ribonuclease P/MRP protein subunit POP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014178 VERSION NP_014178.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183059.1 REFERENCE 1 (residues 1 to 875) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 875) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 875) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 875) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10335. Method: conceptual translation. FEATURES Location/Qualifiers source 1..875 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..875 /product="ribonuclease P/MRP protein subunit POP1" /EC_number="3.1.26.5" /calculated_mol_wt="100265" Region 62..300 /region_name="POP1" /note="Ribonucleases P/MRP protein subunit POP1; pfam06978" /db_xref="CDD:429227" Region 555..661 /region_name="POPLD" /note="POPLD (NUC188) domain; pfam08170" /db_xref="CDD:462391" CDS 1..875 /gene="POP1" /locus_tag="YNL221C" /coded_by="NM_001183059.1:1..2628" /experiment="EXISTENCE:direct assay:GO:0000172 ribonuclease MRP complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0000294 nuclear-transcribed mRNA catabolic process, RNase MRP-dependent [PMID:14729943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:26135751|PMID:23700311]" /experiment="EXISTENCE:direct assay:GO:0005655 nucleolar ribonuclease P complex [PMID:9620854]" /experiment="EXISTENCE:direct assay:GO:0005697 telomerase holoenzyme complex [PMID:27156450]" /experiment="EXISTENCE:direct assay:GO:0034965 intronic box C/D snoRNA processing [PMID:18713869]" /experiment="EXISTENCE:mutant phenotype:GO:0000171 ribonuclease MRP activity [PMID:16618965]" /experiment="EXISTENCE:mutant phenotype:GO:0004526 ribonuclease P activity [PMID:16618965]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:7926742]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:7926742]" /experiment="EXISTENCE:physical interaction:GO:0000172 ribonuclease MRP complex [PMID:17881380]" /note="Subunit of RNase MRP, nuclear RNase P and telomerase complexes; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA; binds to the RPR1 RNA subunit in RNase P" /db_xref="GeneID:855500" /db_xref="SGD:S000005165" ORIGIN 1 msgslsrgng gkkvlnknql lkrnrirnar siraeavaas stktgtpsdl sesgsklnvd 61 qfissrqfev kqlqlamhns kaasstrifq alprklrrrt ashnvrripk rmrnralrem 121 rksdqqdvlk gssassrkah glnakqlyka rmsikllrla skstsmklsm ppevtssnch 181 vrqkiktlkr mikesstanp nikllnnrmg sydctgvnel apipkgrvky tkrqkhfawl 241 pthiwnakrs hmmkrwgyqm vwaptqkcfk lthrlggdtc ssdgalcmds syigtiivkd 301 ksndsegdfl ksiigkltae ranlrkyreg qvlfqgliys fneengedst kplgpcdvfw 361 vqkdtaiirl hpsiytqvfn illqhkeklt vqdcryslas vtlkgakale slasclrste 421 ysksfeqfkm vsmitdhnal pqrctfafea idprhlaapk klndsqrktv nsddilslhe 481 nypqdeinav fnelcdpesr tqsynnqntl keisarrykl ltatpnsink ttvpfkesdd 541 psiplviirr lktrdwivvl pwfwllplwh llnriprmyh iglrqfqqiq yenkqlyfpd 601 dypftqlgyi ensfykkeas ktkwdrkpmg krinfekikd ihntklpays geigdffssd 661 wrflqilrng idylqrndkt lelmdskktg qfnaqgvrdi ncvndvlefc kdyeaktkam 721 slsieenipv alcknrkcqf rtpdsisvns ssfsltffpr ciiavsctll erghpkdnar 781 iyqvpekdle hwlqlakgvy rpngrkdhdl kiplpevhdl igfitsgtyh lncgngmgig 841 fidhhaairq ptryvlirnv gtntyrlgew skisv // LOCUS NP_014179 433 aa linear PLN 30-JUN-2025 DEFINITION adenylosuccinate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014179 VERSION NP_014179.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183058.1 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10336. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..433 /product="adenylosuccinate synthase" /EC_number="6.3.4.4" /calculated_mol_wt="48148" Region 4..428 /region_name="Adenylsucc_synt" /note="Adenylosuccinate synthetase; pfam00709" /db_xref="CDD:459912" CDS 1..433 /gene="ADE12" /locus_tag="YNL220W" /gene_synonym="BRA9" /coded_by="NM_001183058.1:1..1302" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:8706758]" /experiment="EXISTENCE:direct assay:GO:0004019 adenylosuccinate synthase activity [PMID:8706758|PMID:10417315]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004019 adenylosuccinate synthase activity [PMID:5807803]" /experiment="EXISTENCE:mutant phenotype:GO:0006164 purine nucleotide biosynthetic process [PMID:5807803]" /note="Adenylosuccinate synthase; catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence" /db_xref="GeneID:855501" /db_xref="SGD:S000005164" ORIGIN 1 mvnvvlgsqw gdegkgklvd llvgkydiva rcaggnnagh tivvdgvkyd fhmlpsglvn 61 pncqnllgng vvihvpsffk eletleakgl knarsrlfvs srahlvfdfh qvtdklrele 121 lsgrskdgkn igttgkgigp tystkasrsg lrvhhlvndq pgaweefvar ykrlletrrq 181 rygdfeydfe aklaeykklr eqlkpfvvds vvfmhnaiea kkkilvegan almldidfgt 241 ypyvtssntg iggvltglgi pprtideiyg vvkayttrvg egpfpteqln engeklqtig 301 aefgvttgrk rrcgwldlvv lkystlingy tslnitkldv ldtfkeipvg isysiqgkkl 361 dlfpedlnil gkveveykvl pgwdqditki tkyedlpena kkylkyiedf vgvpvewvgt 421 gparesmlhk eik // LOCUS NP_014180 555 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014180 VERSION NP_014180.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183057.1 REFERENCE 1 (residues 1 to 555) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 555) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 555) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 555) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10337. Method: conceptual translation. FEATURES Location/Qualifiers source 1..555 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..555 /product="dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase" /EC_number="2.4.1.259" /EC_number="2.4.1.261" /calculated_mol_wt="63646" Region 20..414 /region_name="Glyco_transf_22" /note="Alg9-like mannosyltransferase family; pfam03901" /db_xref="CDD:281842" CDS 1..555 /gene="ALG9" /locus_tag="YNL219C" /coded_by="NM_001183057.1:1..1668" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:15987956]" /experiment="EXISTENCE:direct assay:GO:0052918 dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [PMID:15987956]" /experiment="EXISTENCE:direct assay:GO:0052926 dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [PMID:15987956]" /experiment="EXISTENCE:mutant phenotype:GO:0000030 mannosyltransferase activity [PMID:8692962]" /experiment="EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:8692962]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:8692962]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:15987956]" /note="Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of both the seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; human homolog ALG9 can complement yeast null mutant; mutation of human homolog causes type 1 congenital disorders of glycosylation" /db_xref="GeneID:855502" /db_xref="SGD:S000005163" ORIGIN 1 mnckavtisl llllfltrvy iqptfslisd cdetfnywep lnllvrgfgk qtweyspeys 61 irswafllpf ycilypvnkf tdleshwnff itraclgffs fimefklhre iagslalqia 121 niwiifqlfn pgwfhasvel lpsavamlly vgatrhslry lstgstsnft kslaynflas 181 ilgwpfvlil slplclhylf nhriistirt afdcclifsl tafavivtds ifygklapvs 241 wnilfynvin aseesgpnif gvepwyyypl nlllnfplpv lvlailgifh lrlwplwasl 301 ftwiavftqq phkeerflyp iyglitlsas iafykvlnlf nrkpilkkgi klsvllivag 361 qamsrivalv nnytapiavy eqfsslnqgg vkapvvnvct grewyhfpss fllpdnhrlk 421 fvksgfdgll pgdfpesgsi fkkirtlpkg mnnkniydtg kewpitrcdy fidivapinl 481 tkdvfnplhl mdnwnklaca afidgenski lgrafyvpep inrimqivlp kqwnqvygvr 541 yidyclfekp tettn // LOCUS NP_014181 587 aa linear PLN 30-JUN-2025 DEFINITION ssDNA-dependent ATPase MGS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014181 VERSION NP_014181.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183056.1 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10338. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..587 /product="ssDNA-dependent ATPase MGS1" /calculated_mol_wt="66413" Region <2..>147 /region_name="RAD18" /note="RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]; COG5432" /db_xref="CDD:227719" Region 11..33 /region_name="ZnF_Rad18" /note="Rad18-like CCHC zinc finger; smart00734" /db_xref="CDD:128973" Region 134..558 /region_name="PRK13342" /note="recombination factor protein RarA; Reviewed" /db_xref="CDD:237355" CDS 1..587 /gene="MGS1" /locus_tag="YNL218W" /coded_by="NM_001183056.1:1..1764" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:16251400]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:11459965|PMID:16251400]" /experiment="EXISTENCE:direct assay:GO:0033567 DNA replication, Okazaki fragment processing [PMID:16251400]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:32748509]" /experiment="EXISTENCE:genetic interaction:GO:0006282 regulation of DNA repair [PMID:16809783]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:32748509]" /note="Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress" /db_xref="GeneID:855503" /db_xref="SGD:S000005162" ORIGIN 1 msnkrtsveq liscpicsrk vffslinshl dicgkekskp ssrpqtvssl lagpkkrkqa 61 nsekfidlen kdheikpglk sesddieive neskrfkaap stdfaksive passrdqlhn 121 dyesrwlqki shlplseklr pkelrdyvgq qhilsqdngt lfkyikqgti psmilwgppg 181 vgktslarll tktattssne snvgsryfmi etsatkantq elrgifeksk keyqltkrrt 241 vlfideihrf nkvqqdlllp hvengdiili gattenpsfq lnnalisrcl ifvleklnvn 301 elcivlsrgi allnkcrkqv wnienplkls rsileyvvdl svgdtrraln mlemievstr 361 erkadeeels iddvrdiikn nssnglntyy dpkgdnhydt isafhksirg gdenaslyyl 421 armlqggedp lyvarrmiri asediglrds sllplavaah davmkvglpe adlalaqccv 481 alarapksve lyrawkklra mmsenmysla sseipmhirn aptklmeelg yhkgykynpd 541 yiegkvqqdy fpkevlekcp nktdlkfldg khlgdkedpd lrqsyqg // LOCUS NP_014182 326 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine-protein phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014182 VERSION NP_014182.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183055.1 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10339. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..326 /product="putative serine/threonine-protein phosphatase" /EC_number="3.6.1.10" /calculated_mol_wt="37020" Region 64..307 /region_name="MPP_PPP_family" /note="phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; cd00144" /db_xref="CDD:277316" Site order(68,70,98,102,126..127,211,233,277) /site_type="active" /db_xref="CDD:277316" Site order(68,70,98,126,211,277) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277316" CDS 1..326 /gene="PPN2" /locus_tag="YNL217W" /coded_by="NM_001183055.1:1..981" /experiment="EXISTENCE:direct assay:GO:0000298 endopolyphosphatase activity [PMID:31175919|PMID:28302909]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:23708375]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005775 vacuolar lumen [PMID:28302909]" /experiment="EXISTENCE:direct assay:GO:0006798 polyphosphate catabolic process [PMID:28302909]" /experiment="EXISTENCE:genetic interaction:GO:0000298 endopolyphosphatase activity [PMID:28302909]" /experiment="EXISTENCE:genetic interaction:GO:0006798 polyphosphate catabolic process [PMID:28302909]" /experiment="EXISTENCE:genetic interaction:GO:0016036 cellular response to phosphate starvation [PMID:28302909]" /experiment="EXISTENCE:genetic interaction:GO:0071469 cellular response to alkaline pH [PMID:39590716]" /experiment="EXISTENCE:mutant phenotype:GO:0000298 endopolyphosphatase activity [PMID:28302909]" /experiment="EXISTENCE:mutant phenotype:GO:0006798 polyphosphate catabolic process [PMID:39590716|PMID:28302909]" /experiment="EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:39590716]" /note="Zn2+-dependent endopolyphosphatase; required with PPN1 to mobilize polyphosphate stores in response to phosphate starvation; member of the PPP-superfamily of metalloproteases; directly involved in adaptation to mild alkaline conditions through polyphosphate hydrolysis; localizes to the vacuolar lumen via the MVB pathway; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate" /db_xref="GeneID:855504" /db_xref="SGD:S000005161" ORIGIN 1 medkrkrraa tlstalilfv accvytlyif kfdnprlspp vsllptistl kkiehvtdln 61 keyvfvgdvh gnydefieli ddkigglgen itmillgdfi hkgpdsdkvv syilnhkdqv 121 kcvlgnheil vmmaylnpdf skwvrrpklm tpltfstetn fipqdiskis nahgrlarel 181 gfsklsqlae hcsmaieldl ditgdilfga hagmvpgdfm kpnqipgvss lsnmkyvdkk 241 nwsktsreke nknyvrwytl wdkygdhfsn akvfyghdas mglnlrrqtk gldtaciknn 301 llssmkvkyd ikkgqydyel iqvqcs // LOCUS NP_014183 827 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcription factor RAP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014183 VERSION NP_014183.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183054.1 REFERENCE 1 (residues 1 to 827) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 827) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 827) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 827) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 827) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10340. Method: conceptual translation. FEATURES Location/Qualifiers source 1..827 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..827 /product="DNA-binding transcription factor RAP1" /calculated_mol_wt="92283" Region 127..206 /region_name="BRCT_2" /note="BRCT domain, a BRCA1 C-terminus domain; pfam16589" /db_xref="CDD:465186" Region 360..413 /region_name="rap1_myb-like" /note="DNA-binding modules of yeast Rap1 and related proteins; cd11655" /db_xref="CDD:212554" Region 448..579 /region_name="Rap1-DNA-bind" /note="Rap1, DNA-binding; pfam09197" /db_xref="CDD:401223" Region 727..824 /region_name="rap1_RCT" /note="C-terminal domain of RAP1 recruits proteins to telomeres; cd11653" /db_xref="CDD:212167" Site order(730,733..734,737,748..749,752..753,755..756,759..761, 821) /site_type="other" /note="recruitment target interaction site [polypeptide binding]" /db_xref="CDD:212167" CDS 1..827 /gene="RAP1" /locus_tag="YNL216W" /gene_synonym="GRC4; GRF1; TBA1; TUF1" /coded_by="NM_001183054.1:1..2484" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11455386]" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:16956377|PMID:9710643|PMID:26399229]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:1904543]" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:10487921|PMID:12051841]" /experiment="EXISTENCE:direct assay:GO:0001094 TFIID-class transcription factor complex binding [PMID:17074814]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:18195009|PMID:20559389]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2656680]" /experiment="EXISTENCE:direct assay:GO:0010833 telomere maintenance via telomere lengthening [PMID:9020083]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:18195009]" /experiment="EXISTENCE:direct assay:GO:0031492 nucleosomal DNA binding [PMID:19782036]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:8510148|PMID:2225074|PMID:17656141]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:31742863]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:8194531]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20559389]" /experiment="EXISTENCE:direct assay:GO:0061849 telomeric G-quadruplex DNA binding [PMID:8052638]" /experiment="EXISTENCE:direct assay:GO:0070187 shelterin complex [PMID:23746845]" /experiment="EXISTENCE:direct assay:GO:0071919 G-quadruplex DNA formation [PMID:8052638]" /experiment="EXISTENCE:genetic interaction:GO:0006110 regulation of glycolytic process [PMID:15300680]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:7958893]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:7958893]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15300680]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:2010087]" /experiment="EXISTENCE:mutant phenotype:GO:0000723 telomere maintenance [PMID:2237406]" /experiment="EXISTENCE:mutant phenotype:GO:0000781 chromosome, telomeric region [PMID:27122604]" /experiment="EXISTENCE:mutant phenotype:GO:0010833 telomere maintenance via telomere lengthening [PMID:9020083]" /experiment="EXISTENCE:mutant phenotype:GO:0031848 protection from non-homologous end joining at telomere [PMID:16096640]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:2010087]" /experiment="EXISTENCE:physical interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:12080091]" /experiment="EXISTENCE:physical interaction:GO:0070200 establishment of protein localization to telomere [PMID:11689698]" /experiment="EXISTENCE:physical interaction:GO:0071169 establishment of protein localization to chromatin [PMID:11689698]" /note="Essential DNA-binding transcription regulator that binds many loci; involved in transcription activation, repression, chromatin silencing, telomere length maintenance; represses divergent noncoding transcription at highly expressed genes, prevents transcription initiation at cryptic promoters near its binding sites; relocalizes to cytosol under hypoxia; recruits Sir complex to telomeric DNA; present in quiescent cell telomere hyperclusters" /db_xref="GeneID:855505" /db_xref="SGD:S000005160" ORIGIN 1 msspddfeta paeyvdaldp smvvvdsgsa avtapsdsaa evkanqneen tgataaetse 61 kvdqtevekk ddddttevgv ttttpsiadt aataniasts gasvtepttd dtaadekkeq 121 vsgpplsnmk fylnrdadah dslndidqla rliranggev ldskpreske nvfivspynh 181 tnlptvtpty ikaccqsnsl lnmenylvpy dnfrevvdsr lqeeshsngv dnsnsnsdnk 241 dsirpkteii stntngated stsekvmvda eqqarlqeqa qllrqhvsst asitsgghnd 301 lvqieqpqkd tsnnnnsnvn dedndlltqd nnpqtadegn asfqaqrsmi srgalpshnk 361 asftdeedef ildvvrknpt rrtthtlyde ishyvpnhtg nsirhrfrvy lskrleyvye 421 vdkfgklvrd ddgnliktkv lppsikrkfs adedytlaia vkkqfyrdlf qidpdtgrsl 481 itdedtptai arrnmtmdpn hvpgsepnfa ayrtqsrrgp iareffkhfa eehaahtena 541 wrdrfrkfll aygiddyisy yeaekaqnre pepmknltnr pkrpgvptpg nynsaakrar 601 nyssqrnvqp tanaasanaa aaaaaaasns yaipenelld edtmnfissl kndlsnisns 661 lpfeypheia eairsdfsne diydnidpdt isfppkiatt dlflplffhf gstrqfmdkl 721 hevisgdyep sqaeklvqdl cdetgirknf stsiltclsg dlmvfpryfl nmfkdnvnpp 781 pnvpgiwthd ddeslksndq eqirklvkkh gtgrmemrkr ffekdll // LOCUS NP_014184 320 aa linear PLN 30-JUN-2025 DEFINITION Ies2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014184 VERSION NP_014184.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183053.1 REFERENCE 1 (residues 1 to 320) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 320) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 320) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 320) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 320) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10341. Method: conceptual translation. FEATURES Location/Qualifiers source 1..320 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..320 /product="Ies2p" /calculated_mol_wt="36023" Region 237..>290 /region_name="PAPA-1" /note="PAPA-1-like conserved region; pfam04795" /db_xref="CDD:461431" CDS 1..320 /gene="IES2" /locus_tag="YNL215W" /coded_by="NM_001183053.1:1..963" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855506" /db_xref="SGD:S000005159" ORIGIN 1 mdseasdiea elsdsvsagg eeyiddddyt ediddqivta kssrrtarrs vpkgvrtskr 61 irdkelsvev dedydeeedv lspskkrhlh trsmdkrqva ataseksdig dskgndgeie 121 dgileeeesl ekelnrgggk evekseesyy aqndvgqkge eeqdgesggy ednepsiske 181 sdelvsvvng ngneeddeve atkenttdst rstttrskml ldlledggsk kkltdeeiql 241 rraenarkrk nlsekrleee kqdtinkllk kragksrshl pnddekndgs ssfvkprrpy 301 nsegmtrilr ryeedlfctf // LOCUS NP_014185 199 aa linear PLN 30-JUN-2025 DEFINITION Pex17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014185 VERSION NP_014185.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183052.1 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10342. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..199 /product="Pex17p" /calculated_mol_wt="23038" CDS 1..199 /gene="PEX17" /locus_tag="YNL214W" /gene_synonym="PAS9" /coded_by="NM_001183052.1:1..600" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:9425153]" /experiment="EXISTENCE:direct assay:GO:1902495 transmembrane transporter complex [PMID:20154681]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:20154681|PMID:12667447|PMID:22375831]" /experiment="EXISTENCE:mutant phenotype:GO:0005778 peroxisomal membrane [PMID:9425153]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9425153|PMID:16679311|PMID:12667447]" /experiment="EXISTENCE:physical interaction:GO:0016560 protein import into peroxisome matrix, docking [PMID:16679311]" /note="Membrane peroxin of the peroxisomal importomer complex; complex facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis" /db_xref="GeneID:855507" /db_xref="SGD:S000005158" ORIGIN 1 mtsinsfprn idwpsnigik kiegtnptvn aikgllyngg siyaflyfvi amfveptlqk 61 qyqqrndfsl fvllrlrrii aqlqkrlvmt pvsslgfneq nnfverstqt sddniiredn 121 shwaemiyql qnmkqelqyf nrssgqpses iddfvfqikm vtdqveltdr srafsnksrn 181 iiqgireikg wfvngqvpr // LOCUS NP_014186 214 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial ribosome assembly protein RRG9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014186 VERSION NP_014186.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183051.1 REFERENCE 1 (residues 1 to 214) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 214) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 214) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 214) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10343. Method: conceptual translation. FEATURES Location/Qualifiers source 1..214 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..214 /product="mitochondrial ribosome assembly protein RRG9" /calculated_mol_wt="25143" Region 77..>129 /region_name="Neugrin" /note="pfam06413" /db_xref="CDD:428925" CDS 1..214 /gene="RRG9" /locus_tag="YNL213C" /coded_by="NM_001183051.1:1..645" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:19751518]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:10029995]" /note="hypothetical protein; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:855508" /db_xref="SGD:S000005157" ORIGIN 1 mnilriacrs fhclrcgpll nenrgwsskk iiklvnkssl snkeftekvr dgtkdipewk 61 kqkmavrkkl qgqrwnppkk isqeqmealr llkfnfpelt asdladrfki speavrrilk 121 snwkrtdeen nntyerwkrr gerikemyqr kedadfvsnq ivtsrkiilg snsnspelia 181 rnvrtfkpfk pnnstpekkn tnklyilkhl gskq // LOCUS NP_014187 782 aa linear PLN 30-JUN-2025 DEFINITION Vid27p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014187 VERSION NP_014187.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183050.1 REFERENCE 1 (residues 1 to 782) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 782) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 782) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 782) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 782) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10344. Method: conceptual translation. FEATURES Location/Qualifiers source 1..782 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..782 /product="Vid27p" /calculated_mol_wt="88715" Region 1..782 /region_name="VID27" /note="Protein involved in vacuole import and degradation [Intracellular trafficking and secretion]; COG5167" /db_xref="CDD:227496" CDS 1..782 /gene="VID27" /locus_tag="YNL212W" /coded_by="NM_001183050.1:1..2349" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic hypothetical protein; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth; contains two PH-like domains" /db_xref="GeneID:855509" /db_xref="SGD:S000005156" ORIGIN 1 mnilkkfmes gnkpelitip sgqfnllrsk nspkaaleci ynnatlsvrk igkfdyelav 61 yrveddsegg tgdeaenfed dtisvlstqs kkkeeewsve isdkimfhkt wdkqgnvalv 121 wenlrgdeqd ekvqfvvaad vsfsdveqfi qtvyrcqfev rnkkssltas addlkeiehr 181 strlfvqddd deldsssddf qdakdtsfeh ekeseilert psplkkvpeg eycclvmssl 241 ymydpiqekf ilqepvvkva iidtgkyefw laiegkdnrl gtqvapninp tfelatdafl 301 fnytlqnitl symlkfkdld kciqfrfawv kclwmtlnke twtdvpekek dyildsssvp 361 lekqfddilh iddrsneerd kessesends ededdendhs kriisseafe eprratskgn 421 ssltvafrnn rsyvtrdnri gvfktddedd slefvaaikn isnlggksid phkpmlymed 481 rnliltdgen enklykmdie rgkvieewst gdknvvqygp tkkfdqmtpe qtivgvsqkg 541 vfkidpring knkiavdesk dyvgkynfss igttesgyia igsekgdikl ydrlgirakt 601 aipslgqaik fittsadgkw llatcestll lmdlkikdgk nagnigflks fpasenvkty 661 vlkirpehsa siltytkkpi rftkayfntg igqqeqtivt stgpyaisws lkgilnqdgs 721 nnypyrirry nadvvadnfe fgsdkkviva lkddvslskv ksfkqpskgv lmpsaslqdf 781 yg // LOCUS NP_014188 86 aa linear PLN 30-JUN-2025 DEFINITION Mrx7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014188 VERSION NP_014188.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183049.1 REFERENCE 1 (residues 1 to 86) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 86) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 86) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 86) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10345. Method: conceptual translation. FEATURES Location/Qualifiers source 1..86 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..86 /product="Mrx7p" /calculated_mol_wt="10517" Region 7..72 /region_name="Mrx7" /note="MIOREX complex component 7; pfam10906" /db_xref="CDD:371295" CDS 1..86 /gene="MRX7" /locus_tag="YNL211C" /coded_by="NM_001183049.1:1..261" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene" /db_xref="GeneID:855510" /db_xref="SGD:S000005155" ORIGIN 1 mpprsieewf yykllsspgf hrfvrkvyrk vngikedpft dqstafqyly kptprqkfka 61 lrllfwdemr stfgfrrrlg drfkkd // LOCUS NP_014189 270 aa linear PLN 30-JUN-2025 DEFINITION Mer1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014189 VERSION NP_014189.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183048.1 REFERENCE 1 (residues 1 to 270) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 270) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 270) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 270) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10346. Method: conceptual translation. FEATURES Location/Qualifiers source 1..270 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..270 /product="Mer1p" /calculated_mol_wt="30980" Region 188..263 /region_name="KH-I" /note="K homology (KH) RNA-binding domain, type I; cl00098" /db_xref="CDD:469614" CDS 1..270 /gene="MER1" /locus_tag="YNL210W" /coded_by="NM_001183048.1:1..813" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:10983980]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7891689]" /experiment="EXISTENCE:direct assay:GO:1990446 U1 snRNP binding [PMID:10983980]" /experiment="EXISTENCE:genetic interaction:GO:0007131 reciprocal meiotic recombination [PMID:2659434]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:2659434]" /experiment="EXISTENCE:mutant phenotype:GO:0048026 positive regulation of mRNA splicing, via spliceosome [PMID:10983980]" /note="mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22" /db_xref="GeneID:855511" /db_xref="SGD:S000005154" ORIGIN 1 msnqhspqpf cldtklvkll eelqegkqfn nknifpekal ylklaldysf frknllefcv 61 hldkikgvir pnydtiyilc llevdllnlv ftdnileicl prfvsredlr vfnntfytyh 121 dnrlrilqed fsqlfkkikt kasvlcftve eifltnqeil pqnstvaelq kstnkvqtng 181 pqrhdfivtl eiklnktqit fligakgtri eslreksgas ikiipisdkm tahernhpes 241 vqqtilisgd lysialavts iesalitldl // LOCUS NP_014190 613 aa linear PLN 30-JUN-2025 DEFINITION Hsp70 family ATPase SSB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014190 VERSION NP_014190.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183047.1 REFERENCE 1 (residues 1 to 613) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 613) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 613) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 613) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10347. Method: conceptual translation. FEATURES Location/Qualifiers source 1..613 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..613 /product="Hsp70 family ATPase SSB2" /EC_number="3.6.4.10" /calculated_mol_wt="66464" Region 6..575 /region_name="PTZ00009" /note="heat shock 70 kDa protein; Provisional" /db_xref="CDD:240227" CDS 1..613 /gene="SSB2" /locus_tag="YNL209W" /gene_synonym="YG103" /coded_by="NM_001183047.1:1..1842" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9860955]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9670014]" /experiment="EXISTENCE:direct assay:GO:0051083 'de novo' cotranslational protein folding [PMID:9670014]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:20368619]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:20368619]" /experiment="EXISTENCE:genetic interaction:GO:0042149 cellular response to glucose starvation [PMID:19723765]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:1394434]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:15456889]" /experiment="EXISTENCE:mutant phenotype:GO:0006452 translational frameshifting [PMID:16607023]" /experiment="EXISTENCE:physical interaction:GO:0002181 cytoplasmic translation [PMID:1394434]" /note="Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication" /db_xref="GeneID:855512" /db_xref="SGD:S000005153" ORIGIN 1 maegvfqgai gidlgttysc vatyessvei ianeqgnrvt psfvaftpqe rligdaaknq 61 aalnprntvf dakrligrrf ddesvqkdmk twpfkvidvd gnpvievqyl eetktfspqe 121 isamvltkmk eiaeakigkk vekavitvpa yfndaqrqat kdagaisgln vlriinepta 181 aaiayglgag ksekerhvli fdlgggtfdv sllhiaggvy tvkstsgnth lggqdfdtnl 241 lehfkaefkk ktgldisdda ralrrlrtaa erakrtlssv tqttvevdsl fdgedfessl 301 trarfedlna alfkstlepv eqvlkdakis ksqidevvlv ggstripkvq kllsdffdgk 361 qleksinpde avaygaavqg ailtgqstsd etkdlllldv aplslgvgmq gdifgivvpr 421 nttvptikrr tfttvsdnqt tvqfpvyqge rvnckentll gefdlknipm mpagepvlea 481 ifevdangil kvtavekstg kssnitisna vgrlsseeie kmvnqaeefk aadeafakkh 541 earqrlesyv asieqtvtdp vlssklkrgs kskieaalsd alaalqiedp sadelrkaev 601 glkrvvtkam ssr // LOCUS NP_014191 199 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL208W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014191 VERSION NP_014191.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183046.1 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10348. On Feb 23, 2004 this sequence version replaced NP_014191.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..199 /product="uncharacterized protein" /calculated_mol_wt="20020" CDS 1..199 /locus_tag="YNL208W" /coded_by="NM_001183046.1:1..600" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi" /db_xref="GeneID:855513" /db_xref="SGD:S000005152" ORIGIN 1 msanefyssg qqgqynqqnn qertgapnng qygadngnpn gerglfstiv ggsagayags 61 kvsnnhskls gvlgaiggaf lankisderk ehkqqeqygn snfggapqgg hnnhhrqdnn 121 nnnggfggpg gpggqgfgrq gpqgfggpgp qefggpggqg fggpnpqefg gpggqgfggp 181 npqefggqgr qgfnggsrw // LOCUS NP_014192 425 aa linear PLN 30-JUN-2025 DEFINITION protein kinase RIO2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014192 VERSION NP_014192.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183045.1 REFERENCE 1 (residues 1 to 425) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 425) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 425) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 425) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10349. Method: conceptual translation. FEATURES Location/Qualifiers source 1..425 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..425 /product="protein kinase RIO2" /EC_number="2.7.11.1" /calculated_mol_wt="48994" Region 8..91 /region_name="Rio2_N" /note="Rio2, N-terminal; pfam09202" /db_xref="CDD:462715" Region 94..283 /region_name="RIO2_C" /note="C-terminal catalytic domain of the atypical protein serine kinase, RIO2 kinase; cd05144" /db_xref="CDD:270695" Site order(101,106..107,109,121,123,177,189..192,196,233..234, 252..253) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270695" Region <319..425 /region_name="TAF7" /note="TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; cl04653" /db_xref="CDD:471075" Region <355..407 /region_name="DNA_pol_phi" /note="DNA polymerase phi; pfam04931" /db_xref="CDD:461488" CDS 1..425 /gene="RIO2" /locus_tag="YNL207W" /coded_by="NM_001183045.1:1..1278" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:12690111]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12690111|PMID:12612080]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15167894]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12612080]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12612080|PMID:12690111]" /experiment="EXISTENCE:mutant phenotype:GO:0046830 positive regulation of RNA import into nucleus [PMID:12612080]" /note="Essential serine kinase involved in the processing of 20S pre-rRNA; involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p" /db_xref="GeneID:855514" /db_xref="SGD:S000005151" ORIGIN 1 mkldtshmry lttddfrvlq aveqgsrshe vvptplihqi sgmrsqsgtn raisdlakls 61 liskmrnvky dgyrltyngi dylalktmln rdtvysvgnt igvgkesdiy kvsdkngnpr 121 vmkihrlgrt sfhsvrnnrd ylkksnqgan wmhlsrlaan keyqfmsmly skgfkvpepf 181 dnsrhivvme liegypmrrl rkhknipkly sdlmcfivdl ansglihcdf nefnimikdk 241 ledendcgfv vidfpqcisi qhqdadyyfq rdvdcirrff kkklkyepkp dssmldtegf 301 gdgykyaypd fkrdvkrtdn ldelvqasgf skkhpgdrgl etavesmrna vynsdddmsn 361 deaeeengeg dyseedeyyd seldnessed dsedaqeeen eriiealssg venlkmdklg 421 nyile // LOCUS NP_014193 455 aa linear PLN 30-JUN-2025 DEFINITION Rtt106p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014193 VERSION NP_014193.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183044.1 REFERENCE 1 (residues 1 to 455) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 455) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 455) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 455) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10350. Method: conceptual translation. FEATURES Location/Qualifiers source 1..455 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..455 /product="Rtt106p" /calculated_mol_wt="51490" Region 5..44 /region_name="Rtt106_N" /note="Histone chaperone Rtt106 N-terminal domain; pfam18215" /db_xref="CDD:436350" Site order(5,9..10,13,16..17,20..21,23..24,27..28,30..31,34..35, 37..39,42) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:211429" Region 67..205 /region_name="PH1-like_Rtt106" /note="Pleckstrin homology-like domain, repeat 1, of Histone chaperone RTT106 (regulator of Ty1 transposition protein 106); cd13303" /db_xref="CDD:241457" Site order(80,86) /site_type="other" /note="H3 histone binding site [polypeptide binding]" /db_xref="CDD:241457" Site order(86..88,108,134) /site_type="other" /note="dsDNA binding site [nucleotide binding]" /db_xref="CDD:241457" Site 133 /site_type="other" /note="negative patch" /db_xref="CDD:241457" Region 216..300 /region_name="PH2-like_Rtt106" /note="Pleckstrin homology-like domain, repeat 2, of Histone chaperone RTT106 (regulator of Ty1 transposition protein 106); cd13304" /db_xref="CDD:241458" Site order(226,229,245..246) /site_type="other" /note="dsDNA binding site [nucleotide binding]" /db_xref="CDD:241458" Site order(230,286) /site_type="other" /note="negative patch" /db_xref="CDD:241458" Site order(237..238,254,297,300) /site_type="other" /note="K56ac binding site [polypeptide binding]" /db_xref="CDD:241458" Site 261..270 /site_type="other" /note="H3-H4 binding site [polypeptide binding]" /db_xref="CDD:241458" Site order(265,268) /site_type="other" /note="H3 histone binding site [polypeptide binding]" /db_xref="CDD:241458" CDS 1..455 /gene="RTT106" /locus_tag="YNL206C" /coded_by="NM_001183044.1:1..1368" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:20007951]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:18662540|PMID:16157874|PMID:20007951]" /experiment="EXISTENCE:genetic interaction:GO:0006335 DNA replication-dependent chromatin assembly [PMID:18662540]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:18708354]" /experiment="EXISTENCE:genetic interaction:GO:0031507 heterochromatin formation [PMID:20007951|PMID:17410207]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19683497]" /experiment="EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:20007951]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:18708354]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:18708354]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:17410207]" /experiment="EXISTENCE:mutant phenotype:GO:0042393 histone binding [PMID:20007951]" /experiment="EXISTENCE:physical interaction:GO:0042393 histone binding [PMID:16157874]" /note="Histone chaperone; involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition; interacts physically and functionally with Chromatin Assembly Factor-1 (CAF-1)" /db_xref="GeneID:855515" /db_xref="SGD:S000005150" ORIGIN 1 msklfldelp eslsrkigtv vrvlpsslei feelykyaln ensndrsgrh kkpridvssd 61 llktdeiset ntifklegvs vlsplrkkld lvfylsnvdg spvitllkgn drelsiyqln 121 knikmasflp vpekpnliyl fmtytscedn kfsepvvmtl nkentlnqfk nlglldsnvt 181 dfekcveyir kqailtgfki snpfvnstlv dtdaekinsf hlqchrgtke gtlyflpdhi 241 ifgfkkpill fdasdiesit yssitrltfn aslvtkdgek yefsmidqte yakiddyvkr 301 kqmkdksmse elkakskskg qatdgtadqp silqeatrqm qdekkagvfs dddeendqnf 361 eaesdlsdgs gqessdgaed geeaeeddee ddeeedkkgq salnrdnsfa singqpeqel 421 qykefkeple ledipieidn dddeddedgs gveyd // LOCUS NP_014195 300 aa linear PLN 30-JUN-2025 DEFINITION Sps18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014195 VERSION NP_014195.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183042.1 REFERENCE 1 (residues 1 to 300) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 300) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 300) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 300) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10351. Method: conceptual translation. FEATURES Location/Qualifiers source 1..300 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..300 /product="Sps18p" /calculated_mol_wt="34109" Region 6..300 /region_name="COG5347" /note="GTPase-activating protein that regulates ARFs (ADP-ribosylation factors), involved in ARF-mediated vesicular transport [Intracellular trafficking and secretion]" /db_xref="CDD:227651" CDS 1..300 /gene="SPS18" /locus_tag="YNL204C" /gene_synonym="SPX18" /coded_by="NM_001183042.1:1..903" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:7969036]" /note="hypothetical protein, contains a putative zinc-binding domain; expressed during sporulation; SPS18 has a paralog, GCS1, that arose from the whole genome duplication" /db_xref="GeneID:855517" /db_xref="SGD:S000005148" ORIGIN 1 mrlfenskdm enrkrllrak kaagnnncfe cksvnpqfvs csfgificvn canllrgmgt 61 nifcvksitm dnfeekdvrr veksgnnrfg sflskngilq ngiplrekyd nlfaksykrr 121 lanevrsndi nrnmylgfnn fqqytngats qirdrtlrei snnsnasega efvlpekvlg 181 sdnfqdcerf paclssernl dennvtsats tltiekfqnd pigtisrswq llsdalyksy 241 edfkgsvvqp tieniqqrnl pndikrsfvh fneklhetph lpspvfscft ggdilppefn // LOCUS NP_014197 292 aa linear PLN 30-JUN-2025 DEFINITION 2,4-dienoyl-CoA reductase (NADPH) [Saccharomyces cerevisiae S288C]. ACCESSION NP_014197 VERSION NP_014197.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183040.1 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10352. On May 22, 2006 this sequence version replaced NP_014197.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..292 /product="2,4-dienoyl-CoA reductase (NADPH)" /EC_number="1.3.1.124" /calculated_mol_wt="30978" Region 22..270 /region_name="TER_DECR_SDR_a" /note="Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; cd05369" /db_xref="CDD:187627" Site order(31,34..36,55..57,84..87,112..114,135,161..163,180, 206..209,211) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:187627" Site order(56,87,114..117,125,127..128,131,163,165,176,208) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:187627" Site order(89,120..122,124..126,129..130,133,137..138,141..142, 145,149,152,165,169..172,174,177..178,181..182,185..186, 188..195,197,208,231..233,235..237,241,244..245,248,253, 255..260,262..270) /site_type="other" /note="homotetramer interface [polypeptide binding]" /db_xref="CDD:187627" Site order(116,165,176,180) /site_type="active" /db_xref="CDD:187627" Site order(120..122,124,129..130,133,138,141..142,169..172,174, 177..178,181..182,185..186,189,192..193) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:187627" CDS 1..292 /gene="SPS19" /locus_tag="YNL202W" /gene_synonym="SPX19" /coded_by="NM_001183040.1:1..879" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:9268358]" /experiment="EXISTENCE:direct assay:GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity [PMID:9268358]" /experiment="EXISTENCE:direct assay:GO:0009062 fatty acid catabolic process [PMID:9268358]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:7969036]" /note="Peroxisomal 2,4-dienoyl-CoA reductase; auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate" /db_xref="GeneID:855518" /db_xref="SGD:S000005146" ORIGIN 1 mntantldgk fvtegswrpd lfkgkvafvt ggagticrvq tealvllgck aaivgrdqer 61 teqaakgisq lakdkdavla ianvdvrnfe qvenavkktv ekfgkidfvi agaagnfvcd 121 fanlspnafk svvdidllgs fntakaclke lkkskgsilf vsatfhyygv pfqghvgaak 181 agidalaknl avelgplgir snciapgaid nteglkrlag kkykekalak iplqrlgstr 241 diaestvyif spaasyvtgt vlvvdggmwh lgtyfghely pealiksmts kl // LOCUS NP_014198 858 aa linear PLN 30-JUN-2025 DEFINITION Psy2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014198 VERSION NP_014198.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183039.1 REFERENCE 1 (residues 1 to 858) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 858) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 858) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 858) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 858) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 858) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 858) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 858) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10353. Method: conceptual translation. FEATURES Location/Qualifiers source 1..858 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..858 /product="Psy2p" /calculated_mol_wt="97922" Region 193..392 /region_name="PP4R3" /note="Phosphatase 4 regulatory subunit 3; pfam04802" /db_xref="CDD:461435" CDS 1..858 /gene="PSY2" /locus_tag="YNL201C" /coded_by="NM_001183039.1:1..2577" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019888 protein phosphatase regulator activity [PMID:17517611]" /experiment="EXISTENCE:direct assay:GO:0030289 protein phosphatase 4 complex [PMID:16299494|PMID:17517611]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:15598824]" /experiment="EXISTENCE:mutant phenotype:GO:0030289 protein phosphatase 4 complex [PMID:16299494]" /experiment="EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:20951350]" /experiment="EXISTENCE:mutant phenotype:GO:1902660 negative regulation of glucose mediated signaling pathway [PMID:24277933]" /experiment="EXISTENCE:mutant phenotype:GO:2000002 negative regulation of DNA damage checkpoint [PMID:17517611|PMID:16299494]" /experiment="EXISTENCE:mutant phenotype:GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining [PMID:24498054]" /note="Subunit of protein phosphatase PP4 complex; Pph3p and Psy2p form the active complex, Psy4p may provide additional substrate specificity; regulates recovery from the DNA damage checkpoint, the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair and efficient Non-Homologous End-Joining (NHEJ) pathway; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3" /db_xref="GeneID:855520" /db_xref="SGD:S000005145" ORIGIN 1 mslpgtptts ptpmdedteq avsvntepkr vkvyilenne wkdtgtgfci gevdegkfay 61 lvvsdedspt etllkskleg nieyqrqeet livwkdlggk dialsfeesm gcdtlcefiv 121 hvqrniesni slvtvkssdn glgsvhdiit gpvtlpsndq qqnsqtllea lkilnentsf 181 dflknetief ilqsnyidtl ishfhkaeee kipkdlflls niiktlilyn krdilesmve 241 ddrimgivgi leydteypts kanhrkylgs kgpnfkevip lenedlkiim kkcfrlqflk 301 dvvlvrfldd hnfnliseiv mdletciidf lqvgtfldrl ielydtktlp esssekekfv 361 qkrkdgirll qqcvqmsinl davdrskfyk tlvrkglfkv ldyafhmetd snvrilatdt 421 iitiiehdil lihnvqneds fkrqhksapd dksshrkypq dyssstdskl llilstills 481 drspglreqv vqalntllhp egcvgngegs ydlmgrsnye akntsedfps fsyglnsdsi 541 nlnnyhyssd emnnlepese sefqvmeyfa nfynkiapil fgplikkdit temaeidgqi 601 ekvtkddlll ihlvklvsfv ctehdrvlsr rfilengild svskliggnh mmqlrltavr 661 ciknlmcldd kyyhrymisk nlyapvfklf qenidknnla nsciqdffri iitecrayqs 721 dghnrkektn gsydgngndv ktnvnnnrtn ftilnkylvq tygdvlrkat dipfiqdmle 781 tgeenqpdhs sfensieggn disvnmstdg fasnhledid iknvkrlhse iehfendphy 841 sgdqlafkks vdqmnast // LOCUS NP_014199 246 aa linear PLN 30-JUN-2025 DEFINITION NADHX epimerase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014199 VERSION NP_014199.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183038.1 REFERENCE 1 (residues 1 to 246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 246) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10354. Method: conceptual translation. FEATURES Location/Qualifiers source 1..246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..246 /product="NADHX epimerase" /EC_number="5.1.99.6" /calculated_mol_wt="27390" Region 5..224 /region_name="yjeF_nterm" /note="yjeF N-terminal region; TIGR00197" /db_xref="CDD:272956" CDS 1..246 /gene="NNR1" /locus_tag="YNL200C" /coded_by="NM_001183038.1:1..741" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0046496 nicotinamide nucleotide metabolic process [PMID:21994945]" /experiment="EXISTENCE:direct assay:GO:0052856 NAD(P)HX epimerase activity [PMID:21994945]" /note="NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:855521" /db_xref="SGD:S000005144" ORIGIN 1 mstlkvvssk laaeidkelm gpqigftlqq lmelagfsva qavcrqfplr gktetekgkh 61 vfviagpgnn ggdglvcarh lklfgynpvv fypkrserte fykqlvhqln ffkvpvlsqd 121 egnwleylkp ektlcivdai fgfsfkppmr epfkgiveel ckvqniipiv svdvptgwdv 181 dkgpisqpsi npavlvsltv pkpcsshire nqtthyvggr fiprdfankf gfepfgyest 241 dqilkl // LOCUS NP_014200 534 aa linear PLN 30-JUN-2025 DEFINITION Gcr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014200 VERSION NP_014200.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183037.1 REFERENCE 1 (residues 1 to 534) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 534) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 534) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 534) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10355. Method: conceptual translation. FEATURES Location/Qualifiers source 1..534 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..534 /product="Gcr2p" /calculated_mol_wt="57931" Region 28..>143 /region_name="SSP160" /note="Special lobe-specific silk protein SSP160; pfam06933" /db_xref="CDD:115579" CDS 1..534 /gene="GCR2" /locus_tag="YNL199C" /coded_by="NM_001183037.1:1..1605" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27190003]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15817685]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15817685]" /experiment="EXISTENCE:direct assay:GO:0060196 positive regulation of antisense RNA transcription [PMID:27190003]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11333224]" /experiment="EXISTENCE:genetic interaction:GO:0003712 transcription coregulator activity [PMID:11333224]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:0006110 regulation of glycolytic process [PMID:11333224|PMID:2247062]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27190003|PMID:10455229|PMID:15789351|PMID:2247062|PM ID:9335590|PMID:11333224]" /experiment="EXISTENCE:mutant phenotype:GO:0060196 positive regulation of antisense RNA transcription [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:11333224]" /note="Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p" /db_xref="GeneID:855522" /db_xref="SGD:S000005143" ORIGIN 1 mhhqtkldvf iiraynllsn esvisgaslq svtnspqttt ntpsgmvnga vgtgianptg 61 lmgsdstpni deiitstgsn altktnsdsa ngtpngnsss tsaisnasnp attgnnasss 121 atsngiytqa qysqlfakis klynatlssg siddrstspk saielyqrfq qmikelelsf 181 daspyakyfr rldgrlwqik tdselendel wrlvsmsift vfdpqtgqil tqgrrkgnsl 241 ntstkgspsd lqginngnnn gnngnigngs niknygnknm pnnrtkkrgt rvaknakngk 301 nnknsnkern gitdtsafsn ttisnpgtnm lfdpslsqql qkrlqtlsqd vnsrsltgyy 361 tqptspgsgg fefglshadl npnassntmg yntmsnngsh swkrrslgsl dvntlddeav 421 eellqltnts krqrpmttaa egalindgpd tnlnanntqm kvdlnpsnsm gpidteavir 481 plkeaydaii sekgqrivql erelelqrqe tqwlrkmlie dmgcvrsmlr dlqr // LOCUS NP_014202 661 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding protein WHI3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014202 VERSION NP_014202.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183035.1 REFERENCE 1 (residues 1 to 661) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 661) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 661) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 661) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10356. Method: conceptual translation. FEATURES Location/Qualifiers source 1..661 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..661 /product="mRNA-binding protein WHI3" /calculated_mol_wt="71122" Region 510..>559 /region_name="dRRM_Rrp7p" /note="deviant RNA recognition motif (dRRM) in yeast ribosomal RNA-processing protein 7 (Rrp7p) and similar proteins; cl40585" /db_xref="CDD:454777" Region 536..624 /region_name="RRM_scw1_like" /note="RNA recognition motif (RRM) found in yeast cell wall integrity protein scw1 and similar proteins; cd12245" /db_xref="CDD:409691" CDS 1..661 /gene="WHI3" /locus_tag="YNL197C" /coded_by="NM_001183035.1:1..1986" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:24386402]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11691832|PMID:24386402]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11691832]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:35085498]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:24386402|PMID:26777405|PMID:24386330]" /experiment="EXISTENCE:genetic interaction:GO:0007089 traversing start control point of mitotic cell cycle [PMID:11691832]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:14685274]" /experiment="EXISTENCE:mutant phenotype:GO:0003729 mRNA binding [PMID:11691832]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:11691832]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:14685274|PMID:9055077]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0061013 regulation of mRNA catabolic process [PMID:24386330]" /experiment="EXISTENCE:mutant phenotype:GO:0061157 mRNA destabilization [PMID:24386402]" /note="RNA binding protein that modulates mRNA stability; regulates cell cycle, sister chromatid cohesion, and stress response genes; modulates stability and translational efficiency of CLN3 mRNA; colocalizes with P-bodies/stress granules to regulate target mRNAs; regulates cell fate and critical cell size for Start passage; regulates ploidy; self-templating mnemon that forms inactive super-assemblies, preventing G1 arrest in mother cells after unsuccessful mating and causing sterility in old cells" /db_xref="GeneID:855524" /db_xref="SGD:S000005141" ORIGIN 1 mqssvyfdqt gsfasssdnv vssttnthni spshrsslnl nttshpheas grgsasgely 61 lndtnsplai ssmlntlalg smpqdiassn isnhdnnikg syslklsnva kditlrecya 121 ifalaegvks ielqkknsss sitsaslede ndifiiarfe llnlainyav ilnsknelfg 181 psfpnkttve iiddttknlv sfpssaifnd tsrlnksnsg mkrpsllsqr srfsfsdpfs 241 ndsplsqqqs qqqqqqpqqp qqhstqkhsp qqcnqqqvns siplssqgqv iglhsnhshq 301 dlsvestiqt sdigksfllr dnteinekiw gtsgipssin gymstpqpst ptlewgntsa 361 sqhgssfflp saastaiapt nsntsanana ssnngasnng anqalsassq qpmmqignti 421 ntsltssnsl ppyglmssqs qhisnmvnts dmnitpqkqn rfmqqpqpeh mypvnqsntp 481 qkvpparlss srnshknnst tslssnitgs asisqadlsl laripppanp adqnppcntl 541 yvgnlpsdat eqelrqlfsg qegfrrlsfr nknttsnghs hgpmcfvefd dvsfatrala 601 elygrqlprs tvsskggirl sfsknplgvr gpnsrrggsg npnpnvnmls synsnvghik 661 n // LOCUS NP_014203 298 aa linear PLN 30-JUN-2025 DEFINITION Slz1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014203 VERSION NP_014203.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183034.1 REFERENCE 1 (residues 1 to 298) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 298) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 298) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 298) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 298) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10357. Method: conceptual translation. FEATURES Location/Qualifiers source 1..298 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..298 /product="Slz1p" /calculated_mol_wt="34187" CDS 1..298 /gene="SLZ1" /locus_tag="YNL196C" /coded_by="NM_001183034.1:1..897" /experiment="EXISTENCE:direct assay:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:22685417]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:22685417]" /experiment="EXISTENCE:mutant phenotype:GO:2000221 negative regulation of pseudohyphal growth [PMID:22685417]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:22685417]" /experiment="EXISTENCE:physical interaction:GO:0036396 RNA N6-methyladenosine methyltransferase complex [PMID:22685417]" /note="Sporulation-specific protein with a leucine zipper motif; subunit of the MIS complex which controls mRNA methylation during the induction of sporulation; homologous to human ZCH13H3, a subunit of the mammalian m6A methyltransferase complex" /db_xref="GeneID:855525" /db_xref="SGD:S000005140" ORIGIN 1 mmnkvdqiig ykkyevklpk drqvkknksk ggnvdqidtk rekdkmrafg eerkkfldkm 61 aknkkkntsr kdrekpkeve kenykredkr lkeqkklsla kefrfkepns eainqntaae 121 ngkpkpqtgl dfdidhqtvs kimidqaiqt ssplnvqlte lfndnvldvs kdsqfvlqdm 181 eftswerrws ncsttsnatt vssvpdpkyn inynditsfn svalitedln isassnglhe 241 rgkkllqqem eysnkvknvt iglerlcmde kpvpdagitm qqasrwsefp tccdqaai // LOCUS NP_014204 261 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL195C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014204 VERSION NP_014204.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183033.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10358. On Feb 23, 2004 this sequence version replaced NP_014204.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..261 /product="uncharacterized protein" /calculated_mol_wt="28190" CDS 1..261 /locus_tag="YNL195C" /coded_by="NM_001183033.1:1..786" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="hypothetical protein; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL195C has a paralog, HBT1, that arose from the whole genome duplication" /db_xref="GeneID:855526" /db_xref="SGD:S000005139" ORIGIN 1 mlglgqsaqa yasddalnmn qakdktysvp gcgrasdlky phrdghsssh eqrsgilpte 61 cpgptlntga gsigipgcgk vtnrvvsdyn knarstlanf dsskmtearm nsknvpigcq 121 dtsdphfngp idqhvpgags pqsqphhida wnsvssrrad nnnqdmmdpq tassdrynek 181 mmreensgvs assyttkvqg ypasipsfnq eteeketyay gvgdrhnvpr nqimdetnps 241 anvlnatdhs ishpenkvlh k // LOCUS NP_014205 301 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL194C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014205 VERSION NP_014205.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183032.1 REFERENCE 1 (residues 1 to 301) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 301) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 301) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 301) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10359. Method: conceptual translation. FEATURES Location/Qualifiers source 1..301 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..301 /product="uncharacterized protein" /calculated_mol_wt="33950" Region 9..206 /region_name="SUR7" /note="SUR7/PalI family; pfam06687" /db_xref="CDD:399580" CDS 1..301 /locus_tag="YNL194C" /coded_by="NM_001183032.1:1..906" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11784867]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11784867]" /note="Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication" /db_xref="GeneID:855527" /db_xref="SGD:S000005138" ORIGIN 1 msykkfvyfi nlffllgatl ltfflilagg rttgvlknfy wfqastsgfn sapsvtrwyn 61 ynwcgwesrg iavncsskma aqpfsprdnf gssplmpstf lnnrnayyyl srvgwamlli 121 glffllitlv sviasliryn rrtaalatam switlffitl saclytgcya kavkafhhen 181 rdarlgpknf gliwttvfll ivnaicctim vathkrneyi ydrsfastkt vdsqtptpvp 241 tnggipssvp vtevqqsqsh qnhrffkklr tkkrtvtsag depdrvqeer vyteqnvpvv 301 s // LOCUS NP_014206 558 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL193W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014206 VERSION NP_014206.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183031.2 REFERENCE 1 (residues 1 to 558) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 558) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 558) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 558) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 558) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10360. On Apr 26, 2011 this sequence version replaced NP_014206.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..558 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..558 /product="uncharacterized protein" /calculated_mol_wt="63787" CDS 1..558 /locus_tag="YNL193W" /coded_by="NM_001183031.2:1..1677" /note="hypothetical protein; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis" /db_xref="GeneID:855528" /db_xref="SGD:S000005137" ORIGIN 1 mgppknfkhf sksnkhkkeq kalitqedfy laaidceeqa drwllsdikk clrfylkale 61 hyengltald stqegkyniy ynetrlflqi ytdylanngy inilqyvkmd dmpdlsnlvl 121 slpqiiqrfe ivyetfpeqr twdlqfnllt cyltliesld dtvsptvame gadiltltnk 181 yieifqhlvn yllqelqnws enaeqdsddt dtelqrdtld edamqvtrdg sgirtngpvq 241 ppaevmdvse qvtpssltev lanslkfnha lmelvieski sieknvetki lnpiqinfle 301 dttnkfylql rdiidsisaa ipldlkeigl aktlieglni issgtfeslq dfvlqtvsft 361 dlldekdvqg kidlslirvd ivefailcln dyssdaswkl sglltkvlte artlltdyrn 421 qilflknqtl neqlshvvfq lcdvlvnssd nelrryaike steksqktpg gahtlnilmk 481 nanvflnnav aisskqcglq etiidklkrn yihnqakerl lflqrleqks neddgtsasp 541 tamtfdmppe hpfyshyr // LOCUS NP_014207 1131 aa linear PLN 30-JUN-2025 DEFINITION chitin synthase CHS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014207 VERSION NP_014207.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183030.2 REFERENCE 1 (residues 1 to 1131) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1131) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1131) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1131) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1131) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10361. On Apr 26, 2011 this sequence version replaced NP_014207.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1131 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1131 /product="chitin synthase CHS1" /EC_number="2.4.1.16" /calculated_mol_wt="129740" Region 377..453 /region_name="Chitin_synth_1N" /note="Chitin synthase N-terminal; pfam08407" /db_xref="CDD:462467" Site order(453,455,604) /site_type="active" /note="Ligand binding site [active]" /db_xref="CDD:133033" Region 454..619 /region_name="Chitin_synth_1" /note="Chitin synthase; pfam01644" /db_xref="CDD:426363" Region <567..687 /region_name="Glyco_tranf_GTA_type" /note="Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; cl11394" /db_xref="CDD:472172" Region <597..990 /region_name="Chitin_synth_2" /note="Chitin synthase; pfam03142" /db_xref="CDD:367353" Site 602..604 /site_type="active" /note="DXD motif [active]" /db_xref="CDD:133033" CDS 1..1131 /gene="CHS1" /locus_tag="YNL192W" /gene_synonym="USA4" /coded_by="NM_001183030.2:1..3396" /experiment="EXISTENCE:direct assay:GO:0004100 chitin synthase activity [PMID:7952171]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8970154]" /experiment="EXISTENCE:direct assay:GO:0045009 chitosome [PMID:8970154]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:2523889]" /note="Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor" /db_xref="GeneID:855529" /db_xref="SGD:S000005136" ORIGIN 1 msdqnnrsrn eyhsnrknep syelqnahsg lfhssneelt nrnqrytnqn asmgsftpvq 61 slqfpeqsqq tnmlyngddg nnntindner diyggfvnhh rqrpppatae yndvfntnsq 121 qlpsehqynn vpsyplpsin viqttpelih ngsqtmatpi erpffnendy yynnrnsrts 181 psiasssdgy adqearpile qpnnnmnsgn ipqyhdqpfg ynngyhglqa kdyyddpegg 241 yidqrgddyq insylgrnge mvdpydyens lrhmtpmerr eylhddsrpv ndgkeeldsv 301 ksgyshrdlg eydkddfsrd deyddlntid klqfqangvp asssvssigs kesdiivsnd 361 nltanralkr sgteirkfkl wngnfvfdsp isktlldqya tttenantlp nefkfmryqa 421 vtcepnqlae knftvrqlky ltpretelml vvtmynedhi llgrtlkgim dnvkymvkkk 481 nsstwgpdaw kkivvciisd grskinersl allsslgcyq dgfakdeine kkvamhvyeh 541 ttminitnis esevslecnq gtvpiqllfc lkeqnqkkin shrwafegfa ellrpnivtl 601 ldagtmpgkd siyqlwrefr npnvggacge irtdlgkrfv kllnplvasq nfeykmsnil 661 dkttesnfgf itvlpgafsa yrfeavrgqp lqkyfygeim enegfhffss nmylaedril 721 cfevvtkknc nwilkycrss yastdvperv pefilqrrrw lngsffasvy sfchfyrvws 781 sghnigrkll ltveffylff ntliswfsls sfflvfrilt vsialayhsa fnvlsviflw 841 lygictlstf ilslgnkpks tekfyvltcv ifavmmiymi fcsifmsvks fqnilkndti 901 sfeglittea frdivislgs tyclylissi iylqpwhmlt sfiqyillsp syinvlniya 961 fcnvhdlswg tkgamanplg kinttedgtf kmevlvssse iqanydkylk vlndfdpkse 1021 srptepsyde kktgyyanvr slviifwvit nfiivavvle tggiadyiam ksistddtle 1081 takkaeiplm tskasiyfnv ilwlvalsal irfigcsiym ivrffkkvtf r // LOCUS NP_014208 357 aa linear PLN 30-JUN-2025 DEFINITION glutamine amidotransferase subunit DUG3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014208 VERSION NP_014208.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183029.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10362. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..357 /product="glutamine amidotransferase subunit DUG3" /calculated_mol_wt="40050" Region 1..292 /region_name="YafJ" /note="Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; cd01908" /db_xref="CDD:238889" Site order(2,96,121..123,151) /site_type="active" /note="putative active site [active]" /db_xref="CDD:238889" Site order(63,66..67,113,133..134,164) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:238889" CDS 1..357 /gene="DUG3" /locus_tag="YNL191W" /coded_by="NM_001183029.1:1..1074" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:17179087]" /experiment="EXISTENCE:direct assay:GO:0006751 glutathione catabolic process [PMID:22277648]" /experiment="EXISTENCE:direct assay:GO:0036374 glutathione hydrolase activity [PMID:22277648]" /experiment="EXISTENCE:direct assay:GO:0061672 glutathione hydrolase complex [PMID:22277648]" /experiment="EXISTENCE:genetic interaction:GO:0008233 peptidase activity [PMID:17179087]" /experiment="EXISTENCE:genetic interaction:GO:0008242 omega peptidase activity [PMID:17179087]" /experiment="EXISTENCE:mutant phenotype:GO:0006751 glutathione catabolic process [PMID:22277648|PMID:17179087]" /note="Component of glutamine amidotransferase (GATase II); forms a complex with Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)" /db_xref="GeneID:855530" /db_xref="SGD:S000005135" ORIGIN 1 mcrflifkgk qpirlshllt rpahsiinqs fdsrlrldrr rpmngdgfgv ayypldtels 61 edgpclfkai tpawnnqnls tlaektksdl vfahvrasty gvlsetnchp ftyhslcfmh 121 nggisnfkgi krkllnhikd eylnfiqgst dsecafalfl dtldklgydp kkqdgdfgnv 181 alrkamlrti dyirdwtkea nkdeahveps llnfavtdgs tvvvsryits ktdeaaslhf 241 scgssfvets pgeyrverld rnqdvimvas epltfergdw tavptnsilt ikkqtillhp 301 iideyyqedp lylrsstlae skglmgsipl akaveknvpp leregrtrpp tavahia // LOCUS NP_014209 204 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL190W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014209 VERSION NP_014209.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183028.1 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10363. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..204 /product="uncharacterized protein" /calculated_mol_wt="21835" CDS 1..204 /locus_tag="YNL190W" /coded_by="NM_001183028.1:1..615" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:mutant phenotype:GO:0042631 cellular response to water deprivation [PMID:22442684]" /note="Hydrophilin essential in desiccation-rehydration process; cell wall protein; contains a putative GPI-attachment site" /db_xref="GeneID:855531" /db_xref="SGD:S000005134" ORIGIN 1 mkfssvtait latvatvata kkgehdfttt ltlssdgslt tttsthtthk ygkfnktsks 61 ktpnhtgthk ygkfnktsks ktpnhtgthk ygkfnktsks ktpnhtgthk ygkfnktsks 121 ktpnhtgthk ygkfnktsks ktpnhtgthk ygkfnktkhd tttygpgeka rknnaapgps 181 nfnsiklfgv tagsaavaga llll // LOCUS NP_014210 542 aa linear PLN 30-JUN-2025 DEFINITION karyopherin alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_014210 VERSION NP_014210.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183027.1 REFERENCE 1 (residues 1 to 542) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 542) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 542) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 542) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 542) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10364. Method: conceptual translation. FEATURES Location/Qualifiers source 1..542 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..542 /product="karyopherin alpha" /calculated_mol_wt="60310" Region 8..542 /region_name="SRP1" /note="Karyopherin (importin) alpha [Intracellular trafficking and secretion]; COG5064" /db_xref="CDD:227396" Region 89..114 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 125..158 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Site order(149,153,157,191,195,199,233,237,241) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293788" Region 166..202 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 208..242 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 259..284 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 294..326 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Site order(317,321,325,359,363,367,401,405,409) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293788" Region 334..370 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 376..409 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" Region 421..455 /region_name="armadillo repeat" /note="armadillo repeat [structural motif]" /db_xref="CDD:293788" CDS 1..542 /gene="SRP1" /locus_tag="YNL189W" /gene_synonym="KAP60; SCM1" /coded_by="NM_001183027.1:1..1629" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:10725229]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10725229]" /experiment="EXISTENCE:direct assay:GO:0042564 NLS-dependent protein nuclear import complex [PMID:19141610]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:7622450]" /experiment="EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:19141610]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:16929305]" /experiment="EXISTENCE:mutant phenotype:GO:0031144 proteasome localization [PMID:25274630]" /note="Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation" /db_xref="GeneID:855532" /db_xref="SGD:S000005133" ORIGIN 1 mdngtdssts kfvpeyrrtn fknkgrfsad elrrrrdtqq velrkakrde alakrrnfip 61 ptdgadsdee dessvsadqq fysqlqqelp qmtqqlnsdd mqeqlsatvk frqilsrehr 121 ppidvviqag vvprlvefmr enqpemlqle aawaltnias gtsaqtkvvv dadavplfiq 181 llytgsvevk eqaiwalgnv agdstdyrdy vlqcnamepi lglfnsnkps lirtatwtls 241 nlcrgkkpqp dwsvvsqalp tlakliysmd tetlvdacwa isylsdgpqe aiqavidvri 301 pkrlvellsh estlvqtpal ravgnivtgn dlqtqvvina gvlpalrlll sspkenikke 361 acwtisnita gnteqiqavi danlipplvk llevaeyktk keacwaisna ssgglqrpdi 421 irylvsqgci kplcdlleia dnriievtld alenilkmge adkearglni nenadfieka 481 ggmekifncq qnendkiyek aykiietyfg eeedavdetm apqnagntfg fgsnvnqqfn 541 fn // LOCUS NP_014211 433 aa linear PLN 30-JUN-2025 DEFINITION Kar1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014211 VERSION NP_014211.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183026.1 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10365. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..433 /product="Kar1p" /calculated_mol_wt="50522" CDS 1..433 /gene="KAR1" /locus_tag="YNL188W" /coded_by="NM_001183026.1:1..1302" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005825 half bridge of spindle pole body [PMID:10428957]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:1607389]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:3030557]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:8188750|PMID:10428957]" /note="Protein involved in karyogamy and spindle pole body duplication; involved in karyogamy during mating; involved in centrosome separation and duplication during mitosis; localizes to the half-bridge of the spindle pole body; interacts with Spc72p during karyogamy; also interacts with Cdc31p; essential gene" /db_xref="GeneID:855533" /db_xref="SGD:S000005132" ORIGIN 1 mnvtspkdgn hsfskknrfn tnkprfhkln eqaqsinlpe drdsivssnt tsimtddafd 61 ynegiasrtk ninsdsdrsn dtikqnnynk retgynpfyn gsginqrytq frkrefeptl 121 aenkaeeyis dednvkided nienelqftp kikeasilrs sllgqrnvln trnpkskesh 181 ikvkpiinnk sssqrkssaa lrkqlgkplp lpylnspnsd stptlqrkee vftdevlqkk 241 relieskwhr llfhdkkmve kkleslreye rkrmpprgtd vssseqdnsf kistptksyv 301 sleqkplpnl samnnfndvt dnkekeetnn nilkfqaqrd plqilqseie mhtkkldtii 361 ellkddtdsk ekrkvvtndn aapeqmvnkg wrknvmmiyk ksgnimkkyr eyflwticil 421 illycniyvy yrf // LOCUS NP_014212 357 aa linear PLN 30-JUN-2025 DEFINITION Swt21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014212 VERSION NP_014212.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183025.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10366. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..357 /product="Swt21p" /calculated_mol_wt="40177" CDS 1..357 /gene="SWT21" /locus_tag="YNL187W" /coded_by="NM_001183025.1:1..1074" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19451230]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:19451230]" /note="Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats" /db_xref="GeneID:855534" /db_xref="SGD:S000005131" ORIGIN 1 mekkvicqdi fwscdgtsfv svhndfgirq ylvpeesntd klnrnlllpf trffrnqsiv 61 scaidpfytl ynensdrlag drivvggknf plqlyslmdg qcilsydtmn kingeyetvy 121 svkidvesrv ytgscrnkva iydksrrdav wmnqstkkas kgrqsiiscf eeqpmggqal 181 srgsllcgsy anemfqvdcr hqrlerlnyt rtvaggivqi ltsdngryvy vvrrnsdais 241 iydrrnlqhe lnvlrlpfri hhnsaklkay idtayglsmg tpqgtilnwg rdlvefggvp 301 shnsvedpli tsippesewr tnldstipat vvkncpgdpe lfalshggti slcrfgg // LOCUS NP_014213 792 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease UBP10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014213 VERSION NP_014213.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183024.2 REFERENCE 1 (residues 1 to 792) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 792) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 792) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 792) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 792) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 792) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 792) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 792) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10367. On Apr 26, 2011 this sequence version replaced NP_014213.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..792 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..792 /product="ubiquitin-specific protease UBP10" /EC_number="3.4.19.12" /calculated_mol_wt="88401" Region 28..>221 /region_name="PRK05901" /note="RNA polymerase sigma factor; Provisional" /db_xref="CDD:235640" Region 362..730 /region_name="UCH" /note="Ubiquitin carboxyl-terminal hydrolase; pfam00443" /db_xref="CDD:425685" Site order(366,371,691,708) /site_type="active" /db_xref="CDD:239072" CDS 1..792 /gene="UBP10" /locus_tag="YNL186W" /gene_synonym="DOT4" /coded_by="NM_001183024.2:1..2379" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:10490600]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10490600|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22902402]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:31665643]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:15721261|PMID:26587833]" /experiment="EXISTENCE:mutant phenotype:GO:0033567 DNA replication, Okazaki fragment processing [PMID:39294185]" /note="Ubiquitin-specific protease, deubiquitinates Ub-protein moieties; interacts with proteins that function in rRNA production and ribosome biogenesis via its intrinsically disordered regions; stabilizes Rpa190p by deubiquitination; controls PCNA deubiquitylation; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p, possibly other transporters; localized to the nucleolus; null mutant phenotypes are functionally complemented by human USP36" /db_xref="GeneID:855535" /db_xref="SGD:S000005130" ORIGIN 1 mttqesikpl vdrilsnplq fnaamisnks nnndtsaape nssyivigkq hnnnsnstai 61 aataeskqik ennlidrpng kktntvpksm aealllytsk ndkdaadatg akksaelste 121 lsteppssss eddkvgkeee eegeifhear dyveprkasl kerdnadkgd gedigedige 181 digedigedi gedigenlgs platiddssn enekekrkel stsissddei eddededdmd 241 ydssamekel peeeendsss kisegekksl yqdlmenstv evnryepvnn tkengnrnpk 301 geeeeeeeee lkhksrsitp pvtisnlsnf yqfnenindr gslnstrivk nwgdkftnlk 361 prgllnhgvt cytnaavqam lhipsiqhyl fdilmgkyds tisknsvsyt laetskkmwl 421 pvsknprknv sasyinpkhl isrlddincm msewqqedsh eyfmslmsrl qedsvpkghk 481 liesiiydif ggllkqivtc kscgsiskte qpfydlslhl kgkkkldpns dlssdsingt 541 sattstttsn aatkpslsss ssvnlnngsp faaasdlssa nrrfsieksi kdffnpelik 601 vdkeqkgyvc ekchkttnav khssilrape tllvhlkkfr fngtssskmk qavsypmfld 661 lteyceskel pvkyqllsvv vhegrslssg hyiahckqpd gswatyddey iniiserdvl 721 kepnayylly trltpksvpl plaksamatg nvtskskqeq avnepnnrpl kinskknnrk 781 kwkknkkrkf tk // LOCUS NP_014214 158 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL11m MRPL19 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014214 VERSION NP_014214.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183023.1 REFERENCE 1 (residues 1 to 158) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 158) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 158) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 158) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10368. Method: conceptual translation. FEATURES Location/Qualifiers source 1..158 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..158 /product="mitochondrial 54S ribosomal protein uL11m MRPL19" /calculated_mol_wt="16539" Region 4..158 /region_name="L11_bact" /note="50S ribosomal protein uL11, bacterial form; TIGR01632" /db_xref="CDD:233500" Site order(11,31,76..78,82,89,127,132..134,140,143..144, 147..148,150..152) /site_type="other" /note="23S rRNA interface [nucleotide binding]" /db_xref="CDD:100101" Site order(11,59,61..64,68,70..71,128..129,132..133) /site_type="other" /note="L7/L12 interface [polypeptide binding]" /db_xref="CDD:100101" Site order(27,31) /site_type="active" /note="putative thiostrepton binding site [active]" /db_xref="CDD:100101" Site order(95,111) /site_type="other" /note="L25 interface [polypeptide binding]" /db_xref="CDD:100101" CDS 1..158 /gene="MRPL19" /locus_tag="YNL185C" /gene_synonym="uL11m" /coded_by="NM_001183023.1:1..477" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:855536" /db_xref="SGD:S000005129" ORIGIN 1 msqaaknviv klivgagqaa psppvgpalg skgikaidfc kefnarsany qpgvpvpvli 61 tikpdrtftf emkspptgyl llkalkmdkg hgqpnvgtml gsapakgptr algelslkhv 121 yeiakikksd erhsllemeg ivksivgvak smgikvvp // LOCUS NP_001257687 108 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL184C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257687 VERSION NP_001257687.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270758.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35132. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..108 /product="uncharacterized protein" /calculated_mol_wt="12338" CDS 1..108 /locus_tag="YNL184C" /coded_by="NM_001270758.1:1..327" /note="hypothetical protein; expressed at both mRNA and protein levels" /db_xref="GeneID:855537" /db_xref="SGD:S000005128" ORIGIN 1 mkrvtlivlp rrqfpflkfh skealesavn lqlirrkksv niqidsvtfc iyfcllyfrt 61 leyhrgtisl hnvtgskkrd skansrsrps gtitsrgari glqgyksh // LOCUS NP_014216 790 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase NPR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014216 VERSION NP_014216.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183021.1 REFERENCE 1 (residues 1 to 790) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 790) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 790) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 790) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 790) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10369. Method: conceptual translation. FEATURES Location/Qualifiers source 1..790 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..790 /product="serine/threonine protein kinase NPR1" /EC_number="2.7.11.1" /calculated_mol_wt="85859" Region 451..742 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" CDS 1..790 /gene="NPR1" /locus_tag="YNL183C" /coded_by="NM_001183021.1:1..2373" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:19780626]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17095607]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:17095607]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22118465]" /experiment="EXISTENCE:mutant phenotype:GO:0045806 negative regulation of endocytosis [PMID:22118465]" /experiment="EXISTENCE:mutant phenotype:GO:0090153 regulation of sphingolipid biosynthetic process [PMID:23363605]" /note="Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis by phosphorylating Ldb19p; positively regulates activity of the three Mep ammonium transport proteins; mediates inhibitory phosphorylation of Mep2p and Par32p; TOR complex negatively regulates Npr1p activity; NPR1 has a paralog, PRR2, that arose from the whole genome duplication" /db_xref="GeneID:855538" /db_xref="SGD:S000005127" ORIGIN 1 mssltrllqe krknetsnss prtsadtltt tpesqsldlh srnkssshig svsnssssdr 61 nranvpvpgs vttvtqiyse edssstagss lddrnqfsss flnanfahta sfygtsaqsr 121 drfgslindq gtaglsshgg sfaaqnrits rlsttshtsg raipslsssi pysvpnsnkd 181 nnssnsnsss lssswletya ggmpnnisai dsnvisspkv dsveprfvis kqklqkasmd 241 snnanatqsr sisrsgsfss qlgnfffskn skessnsnsa gmsfsansng pspniknpnv 301 tngstpipkp irarqssiys asrqptgsyt dnfygspssv hdhlppsqsv prsqhssigd 361 lkrffkkssn snlssnsnnv ipngsplssg iavpshshss shfaagnnsy stsyngngdt 421 iyshshggsg ipfskryikt gadlgagagg svklaqrisd nkifavkefr tkfeneskrd 481 yvkkitseyc igttlnhpni ietieivyen drilqvmeyc eydlfaivms nkmsyeeicc 541 cfkqiltgvq ylhsiglahr dlkldncvin ekgivklidf gaavvfsypf sknlveasgi 601 vgsdpylape vcifakydpr pvdiwssaii facmilkkfp wkipklrdns fklfcsgrdc 661 dslsslvtrt pdppsydesh stekkkpess snnvsdpnnv nigpqrllhs lpeetqhivg 721 rmidlapacr gnieeimedp wirsidmchl vedglsfkvv rgedhhhtqv dqseahiagl 781 ekkkkkqnnq // LOCUS NP_014217 555 aa linear PLN 30-JUN-2025 DEFINITION chromatin-binding/pre-rRNA-processing protein IPI3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014217 VERSION NP_014217.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183020.1 REFERENCE 1 (residues 1 to 555) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 555) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 555) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 555) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10370. Method: conceptual translation. FEATURES Location/Qualifiers source 1..555 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..555 /product="chromatin-binding/pre-rRNA-processing protein IPI3" /calculated_mol_wt="61642" Region 108..>226 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region <109..383 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 143..187 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 222..255 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..555 /gene="IPI3" /locus_tag="YNL182C" /coded_by="NM_001183020.1:1..1668" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:22421151]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:15528184]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:22421151]" /experiment="EXISTENCE:direct assay:GO:0120330 rixosome complex [PMID:14759368]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:15528184]" /experiment="EXISTENCE:mutant phenotype:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:22421151]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:14759368]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:22421151]" /note="Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p" /db_xref="GeneID:855539" /db_xref="SGD:S000005126" ORIGIN 1 mdeqvifttn tsgtiasvhs feqinlrqcs tqsrnscvqv gnkylfiaqa qkalinvynl 61 sgsfkresve qrlplpeilk clevvendgv qydriqgvnh nlpdfnlpyl llgstesgkl 121 yiwelnsgil lnvkpmahyq sitkiksiln gkyiitsgnd srviiwqtvd lvsasnddpk 181 plcilhdhtl pvtdfqvsss qgkflsctdt klftvsqdat ircydlslig skkkqkanen 241 dvsigktpvl latfttpysi ksivldpadr acyigtaegc fslnlfyklk gnaivnllqs 301 agvntvqkgr vfslvqrnsl tggenedlda lyamgqlvce nvlnsnvscl eismdgtlll 361 igdtegkvsi aeiyskqiir tiqtlttsqd svgevtnllt npyrlergnl lfegeskgkq 421 psnnnghnfm kipnlqrvif dgknkghlhd iwyqigepea etdpnlalpl ndfnayleqv 481 ktqesifshi gkvssnvkvi dnkidatssl dsnaakdeei telktnieal thaykelrdm 541 heklyeehqq mldkq // LOCUS NP_014218 407 aa linear PLN 30-JUN-2025 DEFINITION putative oxidoreductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014218 VERSION NP_014218.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183019.2 REFERENCE 1 (residues 1 to 407) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 407) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 407) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10371. On Apr 26, 2011 this sequence version replaced NP_014218.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..407 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..407 /product="putative oxidoreductase" /calculated_mol_wt="46372" Region 53..367 /region_name="retinol-DH_like_SDR_c_like" /note="retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; cd05327" /db_xref="CDD:212492" Site order(60,62..63,65..66,85..87,113..115,143..145,173, 209..211,232,236,276..279,281..282) /site_type="other" /note="putative NAD(P) binding site [chemical binding]" /db_xref="CDD:212492" Site order(174,211,232,236) /site_type="active" /db_xref="CDD:212492" CDS 1..407 /gene="PBR1" /locus_tag="YNL181W" /coded_by="NM_001183019.2:1..1224" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14690591|PMID:14562095]" /note="Putative oxidoreductase; required for cell viability" /db_xref="GeneID:855540" /db_xref="SGD:S000005125" ORIGIN 1 mplniigtal ldgtdkipyy qtikkvapyv latgaikyws rgpsntwerk lhgkvylvtg 61 atsqgmgtsv aykmaelgaq liiltrevde wvtewceelr ektknelifv ekcdlsnlwe 121 irkfatswld nspprrldgv ivmsgdmepw gipkislpqr rsskdglelq iatnyvaifh 181 llnllqpsfk aqppdrdvri ilatcwlqvv gdiniedplw qnakyksalk ffassklqlg 241 lsmmelqrrl tediknqktn gaertgknvt itmvqpgtmr snslrrvisn gsvvlliily 301 cillypilwl ftksgrrgdq sflyalmtpe leevnlkdtk vkyisdcsiv kfarkefdde 361 elqkklfdnt erdilqlekk vaakrnankt gnqnskkksq nksrkdd // LOCUS NP_014219 331 aa linear PLN 30-JUN-2025 DEFINITION Rho family GTPase RHO5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014219 VERSION NP_014219.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183018.1 REFERENCE 1 (residues 1 to 331) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 331) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 331) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 331) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 331) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10372. Method: conceptual translation. FEATURES Location/Qualifiers source 1..331 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..331 /product="Rho family GTPase RHO5" /calculated_mol_wt="36687" Site order(5,35..36,38..39,41,43,82,86..91,97,100) /site_type="other" /note="GEF (guanine nucleotide exchange factor) interaction site [polypeptide binding]" /db_xref="CDD:206641" Region 6..220 /region_name="RHO" /note="Rho (Ras homology) subfamily of Ras-like small GTPases; smart00174" /db_xref="CDD:197554" Site 10..17 /site_type="other" /note="G1 box" /db_xref="CDD:206641" Site order(13..18,35,87..88,157,159,200..201) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206641" Site order(34,36..37,91,97,100) /site_type="other" /note="GAP (GTPase-activating protein) interaction site [polypeptide binding]" /db_xref="CDD:206641" Site order(35..36,89,97,99..100) /site_type="other" /note="GDI (guanine nucleotide dissociation inhibitor) interaction site [polypeptide binding]" /db_xref="CDD:206641" Site 35 /site_type="other" /note="G2 box" /db_xref="CDD:206641" Site 36..40 /site_type="other" /note="Switch I region" /db_xref="CDD:206641" Site order(37,97,100) /site_type="active" /note="effector interaction site [active]" /db_xref="CDD:206641" Site 87..90 /site_type="other" /note="G3 box" /db_xref="CDD:206641" Site order(89..91,97..100,105..107) /site_type="other" /note="Switch II region" /db_xref="CDD:206641" Site 156..159 /site_type="other" /note="G4 box" /db_xref="CDD:206641" Site 199..201 /site_type="other" /note="G5 box" /db_xref="CDD:206641" CDS 1..331 /gene="RHO5" /locus_tag="YNL180C" /gene_synonym="YNS0" /coded_by="NM_001183018.1:1..996" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:18216266]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11591390]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18216266]" /experiment="EXISTENCE:direct assay:GO:0012505 endomembrane system [PMID:18216266]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:18216266]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:18216266]" /note="Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; regulated by phosphorylation and ubiquitination; likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity; necessary for oxidant and ramped heat stress-induced cell death; ortholog of mammalian RAC1" /db_xref="GeneID:855541" /db_xref="SGD:S000005124" ORIGIN 1 mrsikcviig dgavgktsll isyttnsfpt dyvptvfdny sttiaipngt asspleldng 61 ndkrgslssa ssspstdrkl ykinlwdtag qedydrlrpl cypqtdifli cfsvsehasf 121 anvtekwlpe lkqtsniegt slytklgkyp illvgtksdl rddpatqkkl qeansdyvsq 181 eeidelvqrc gfmgytecsa atqagvrevf eqavryaiye pespnqksan htltdeltta 241 ttntngdkni reqkqqphhn nstdstlpkg slqqekealn ikptkkgqkd kiheqskskg 301 skiasnnhhn kqakpktrnd kkkkkskcvi l // LOCUS NP_014221 240 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS3 RPS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014221 VERSION NP_014221.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183016.3 REFERENCE 1 (residues 1 to 240) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 240) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 240) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 240) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10373. On Jul 30, 2012 this sequence version replaced NP_014221.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..240 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..240 /product="40S ribosomal protein uS3 RPS3" /calculated_mol_wt="26372" Region 1..216 /region_name="PTZ00084" /note="40S ribosomal protein S3; Provisional" /db_xref="CDD:240260" CDS 1..240 /gene="RPS3" /locus_tag="YNL178W" /gene_synonym="SUF14" /coded_by="NM_001183016.3:1..723" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:11561734]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916|PMID:385049|PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:16738661]" /experiment="EXISTENCE:genetic interaction:GO:0000056 ribosomal small subunit export from nucleus [PMID:22570489]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:28223523]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:28956756]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:30465652]" /note="Protein component of the small (40S) ribosomal subunit; has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; nascent Rps3p is bound by specific chaperone Yar1p during translation; homologous to mammalian ribosomal protein S3 and bacterial S3" /db_xref="GeneID:855543" /db_xref="SGD:S000005122" ORIGIN 1 mvaliskkrk lvadgvfyae lnefftrela eegysgvevr vtptktevii ratrtqdvlg 61 engrrinelt llvqkrfkya pgtivlyaer vqdrglsava qaesmkfkll nglairraay 121 gvvryvmesg akgcevvvsg klraarakam kfadgflihs gqpvndfidt atrhvlmrqg 181 vlgikvkimr dpaksrtgpk alpdavtiie pkeeepilap svkdyrpaee teaqaepvea // LOCUS NP_014222 309 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL22m MRPL22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014222 VERSION NP_014222.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183015.2 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10374. On Apr 26, 2011 this sequence version replaced NP_014222.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..309 /product="mitochondrial 54S ribosomal protein uL22m MRPL22" /calculated_mol_wt="34766" Region 165..268 /region_name="Ribosomal_L22" /note="Ribosomal protein L22p/L17e; pfam00237" /db_xref="CDD:459725" CDS 1..309 /gene="MRPL22" /locus_tag="YNL177C" /gene_synonym="uL22m" /coded_by="NM_001183015.2:1..930" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:855544" /db_xref="SGD:S000005121" ORIGIN 1 mnfhtarisq vgvisralls svsrrwihvt pislnnsggs lfgsitenkp kegknrgded 61 agsfsnrlai asdssgeape vnrdsitien dkllqqhiis lqqpeqlasq sllsplkrei 121 yeanckingg fykkdtivkl pnsseryklk ltkreievle psvyaqsyri kssmkkatll 181 lrllggldvm kaisqchfsn kkiarevael lqkgvkdgqk lglkpedlyi sqiwtgsdgf 241 wrkrvefkar trigiishpy ihvrcilrtk svtkrrlaye ahlkeqkrap wvqlgdkpir 301 gvtggvykw // LOCUS NP_014223 636 aa linear PLN 30-JUN-2025 DEFINITION Tda7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014223 VERSION NP_014223.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183014.2 REFERENCE 1 (residues 1 to 636) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 636) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 636) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 636) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 636) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10375. On Apr 26, 2011 this sequence version replaced NP_014223.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..636 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..636 /product="Tda7p" /calculated_mol_wt="67270" CDS 1..636 /gene="TDA7" /locus_tag="YNL176C" /coded_by="NM_001183014.2:1..1911" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:14562095]" /note="Cell cycle-regulated gene of unknown function; promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele; TDA7 has a paralog, YDL211C, that arose from the whole genome duplication" /db_xref="GeneID:855545" /db_xref="SGD:S000005120" ORIGIN 1 mnsnstigrt tlgesdtisl sfsepsssln srstdvvfas tstlvpqqgs ltslppvsst 61 atptyystsl tydetlhtsi dvsststlvs stdssssseq dtyssqydpa tssysiitps 121 msifsstspm sssssitsew ssltsttptl sssatslsss wsslsspssl lvssslslsl 181 sssysdtklf sfdsrssifs pstptvisps ytylssisat sfqisttsel ssswfstiss 241 pstisnkdtt fpsssrntst sfyssslsst ndfstiskss klspsassst vsistisvpt 301 sssvsssssk vpsnrpssss ssddttsays stytfqslqs ttsssipptt qtpststist 361 spiptssqvf ntvaisssed sktiyyfytq tyditdsstt fvtglpttia vaksevtsfs 421 apsstitadm sfyqhwldgs ldnnknqgts ktntgtivgs vvgsvggili cvlvvwfmlv 481 rkrkakrhfk endsfcheig rrtgfpttaq akeaslqaqd sgsqqrntet asannpfsne 541 fnfkargnpp pvppprnvta mngsfqnmrs nfmdqenrfs ygssftyssl gsstqggfst 601 lssnsirlgr gldndishde rntvqnnsqg flreii // LOCUS NP_014224 403 aa linear PLN 30-JUN-2025 DEFINITION Nop13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014224 VERSION NP_014224.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183013.2 REFERENCE 1 (residues 1 to 403) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 403) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 403) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 403) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10376. On Apr 26, 2011 this sequence version replaced NP_014224.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..403 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..403 /product="Nop13p" /calculated_mol_wt="45478" Region 127..217 /region_name="RRM1_Nop13p_fungi" /note="RNA recognition motif 1 (RRM1) found in yeast nucleolar protein 13 (Nop13p) and similar proteins; cd12396" /db_xref="CDD:409830" Region 241..316 /region_name="RRM2_Nop13p_fungi" /note="RNA recognition motif 2 (RRM2) found in yeast nucleolar protein 13 (Nop13p) and similar proteins; cd12397" /db_xref="CDD:409831" CDS 1..403 /gene="NOP13" /locus_tag="YNL175C" /coded_by="NM_001183013.2:1..1212" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922|PMID:11452019]" /experiment="EXISTENCE:direct assay:GO:0030684 preribosome [PMID:17922018]" /note="Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM); relative distribution to the nucleolus increases upon DNA replication stress" /db_xref="GeneID:855547" /db_xref="SGD:S000005119" ORIGIN 1 msetelsked avtkkdneeq vkkalldptk krkaedeiei dlkssiplsk kqkrllrrgk 61 vtleelnaky nidpksieey kedaekkksg asekdaqgee stintptgde sgevvkkkkk 121 denkygvwig nlsfdttkdd lvrffiaktk dnedeksrvt eqditrlsmp rvaaknsnam 181 knkgfcymff knveqmkavl elseshlngr nmlikdseny sgrpdkddlv amsknppsri 241 lfvgnlsfdv tddllrkhfq hcgdivkirm atfedsgkck gfafidfkne egstnalkdk 301 scrkiagrpl rmeygedrsk rqvrkkvenv srnnsssfdi snnkgydrag qdngskpeyk 361 rsnanrrppv dsnnrtkssv alataqrgsa aivpsqgkkv kfd // LOCUS NP_014226 366 aa linear PLN 30-JUN-2025 DEFINITION Mdg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014226 VERSION NP_014226.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183011.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10377. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..366 /product="Mdg1p" /calculated_mol_wt="40147" Region 8..87 /region_name="E_set_AMPKbeta_like_N" /note="N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; cd02859" /db_xref="CDD:199889" Site order(28,60,67,78..79,81,83) /site_type="other" /note="glycogen binding site [chemical binding]" /db_xref="CDD:199889" CDS 1..366 /gene="MDG1" /locus_tag="YNL173C" /coded_by="NM_001183011.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8914522|PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:8914522]" /note="Plasma membrane protein; involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations; MDG1 has a paralog, CRP1, that arose from the whole genome duplication" /db_xref="GeneID:855548" /db_xref="SGD:S000005117" ORIGIN 1 mqsslpqftf kwpkgpeaii ltgtfddwkg tlpmvkdpsg afeitlpvtf dspsskfyfk 61 fivdgqwlps kdykvnideg vennfiteed vikqrengss tlvpesagla vsknapliep 121 eaekrakklr kfkikrvikt nkqtgersif sqevvelpds edetqqvnkt gknadglsgt 181 ttiiennvgv neekaikpye enhpkvnlvk segyvtdglg ktqssesrly elsaedleke 241 eeeededkgg gkdtstsada easedqnkep lsksakfekp eekvpvssit shaketsvkp 301 tgkvatetqt yetkqgapta aakkieakka trpskpkgtk etpnkgvqkn paknggffkk 361 laqllk // LOCUS NP_014227 1748 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014227 VERSION NP_014227.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183010.4 REFERENCE 1 (residues 1 to 1748) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1748) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1748) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1748) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10378. On Jul 30, 2012 this sequence version replaced NP_014227.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1748 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1748 /product="anaphase promoting complex subunit 1" /calculated_mol_wt="196032" Region 88..>128 /region_name="ANAPC1" /note="Anaphase-promoting complex subunit 1 WD40 beta-propeller domain; pfam12859" /db_xref="CDD:463732" CDS 1..1748 /gene="APC1" /locus_tag="YNL172W" /coded_by="NM_001183010.4:1..5247" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0060090 molecular adaptor activity [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0007091 metaphase/anaphase transition of mitotic cell cycle [PMID:8895471]" /experiment="EXISTENCE:mutant phenotype:GO:0010458 exit from mitosis [PMID:8895471]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473|PMID:8895471]" /experiment="EXISTENCE:mutant phenotype:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]" /note="Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress" /db_xref="GeneID:855549" /db_xref="SGD:S000005116" ORIGIN 1 mtskpstrnd ylprethnge ytgdspewql qinitnkigg ingdiwlsrd grsvkwcied 61 qclrqftynq kiikagyidf ektpdcfvvv lsdiahvyml knggsttvcf pfqignafwy 121 angvileret sasfmdggyd lkpiefdlkh kyitltdpma pfglisitnt fkgginsasg 181 nktdilqdfq lvlfpsdkdk ciavfldrns kvlrfyysri lssdqsrkge ltisstkktg 241 ldaagnsqks ggiskdlrkf shltrrstsi nsnshdfnaa ervlsgnvgn asgrtdifal 301 psscsrrsls atldrmgnni aptnraapsg ffdsssanta thsnitpvsq pmqqqqqeyl 361 nqtatsskdi vlteisslkl pddiiftsrr lssilsklkf lslrferreg llifhepthf 421 ckiwlidllp dvldsipfki ygnspqnmir lenlklkeps riqamyihel lesclilvse 481 gqnkeeykac lydpfvkits pskniseelt kqnslpslqk lfpypetsft klcfeavkyi 541 tspafnisfi flwqsaysil lsranddvvg glkmehdafs lvlsllilpi psssaqeyqe 601 ykeiyerdlf qhlkqdseit ssvlprivig lhlireeysl nvlcrnehal lgqflrfata 661 amgwpdlwqs yyvpkmdses ktflhpreqn stffhpldep psitkslysi tenssiplcp 721 fisfsrlvat dtqvelritp rsfkilglye lvhspnflpd yvlgilssfk vdkdelqtyp 781 lgilvplqni lkiledklse vrdnlelldr adlqrcsaii nsirsdskev lkrgqrdsym 841 lckvplaknr sslskkpsdi ysilseivks asqvpldgsa mrmsniqdde didegrslkl 901 naglifsedk rfthvvslla yyrptktqff ttkteyaqil aqkkyfakim alrtctngvg 961 wgavayatek pistqkwviq plnlisvfpd dtkitvkape diahdivewg qfhagvssgl 1021 riskkatgit gswiafnkpk eldayhggfl lglglnghlk nleewhiyny lsprnthisi 1081 glllgmsssm kgsmdsklik visvhlvafl psgssdlnid lklqtagiig mgmlylnsrh 1141 krmsdsifaq lvsllnvnde mvadeeyrla agislglinl gagqtklrkw dssllglgdd 1201 lpedvydssd veqnvmyedl ttklleivts tydvendwip ensqigavia imflflksnn 1261 fgisnmlkvd lkeilkanin trpellmyre wasnmilwef igddlsfimk dvdigvkfse 1321 lntdllpiyy tmagrilamg irfastgnlk irnillslvd kflplyqypg kqnldfrlti 1381 svinvltnvi vvslsmvmca sgdlevlrrv kylhevasgp ysdlfqeips sksdvsgvtq 1441 vtsntntpgn sdrervdeta asldderssn gsdisdptay ledkkdiddh ygkfistnla 1501 lgflflgsgq yalntstles iaflsmsvlp tyttphplqe lkhfwsmave prclvikdis 1561 tgdavnnvpi elvveedvek eevireistp cllpdfskik sirvkmhgyf plevnftkdy 1621 sasdffsggt iiyiqrkses vfenkasfrn vedihvalkr kaaesknysr lnlkneqgnt 1681 tssqlveslg iqdltmveld tllsagnnta ltdsesynlg llcsdknsgd ildcqlelwy 1741 ksfgphde // LOCUS NP_014230 500 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylserine decarboxylase 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014230 VERSION NP_014230.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183007.1 REFERENCE 1 (residues 1 to 500) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 500) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 500) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 500) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10379. Method: conceptual translation. FEATURES Location/Qualifiers source 1..500 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..500 /product="phosphatidylserine decarboxylase 1" /EC_number="4.1.1.65" /calculated_mol_wt="56464" Region 169..495 /region_name="PS_decarb" /note="phosphatidylserine decarboxylase precursor; TIGR00163" /db_xref="CDD:272936" CDS 1..500 /gene="PSD1" /locus_tag="YNL169C" /coded_by="NM_001183007.1:1..1503" /experiment="EXISTENCE:direct assay:GO:0004609 phosphatidylserine decarboxylase activity [PMID:23124206]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:23124206]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:34818062]" /experiment="EXISTENCE:direct assay:GO:0006656 phosphatidylcholine biosynthetic process [PMID:6427211]" /experiment="EXISTENCE:direct assay:GO:0016540 protein autoprocessing [PMID:25829489]" /experiment="EXISTENCE:direct assay:GO:0140042 lipid droplet formation [PMID:34818062]" /experiment="EXISTENCE:mutant phenotype:GO:0004609 phosphatidylserine decarboxylase activity [PMID:8407984]" /experiment="EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:30926815]" /experiment="EXISTENCE:mutant phenotype:GO:0010636 positive regulation of mitochondrial fusion [PMID:23045528]" /experiment="EXISTENCE:mutant phenotype:GO:0010954 positive regulation of protein processing [PMID:23045528]" /note="Phosphatidylserine decarboxylase of the mitochondrial inner membrane; converts phosphatidylserine to phosphatidylethanolamine; regulates mitochondrial fusion and morphology; partly exposed to the mitochondrial intermembrane space; ER-localized fraction is involved in formation of lipid droplets; autocatalytically processed" /db_xref="GeneID:855552" /db_xref="SGD:S000005113" ORIGIN 1 msimpvknal aqgrtllmgr mpavkfstrm qlrnrtavlw nrkfstrlfv qqrrssgeiv 61 drakaaaans grkqvsmkwv vltsftivlg tillvsrnds teedategkk grrtrkikif 121 nnnwlffcys tlplnamsrl wgqvnsltlp iwvrpwgyrl ysflfgvnld emedpdlthy 181 anlseffyrn ikpgtrpvaq gedviaspsd gkilqvgiin setgeieqvk gmtysikefl 241 gthshplmsk sassldltsd eekhrefarv nriqlagsed teqpllnfkn egdqsvrefk 301 psvsknihll sqlslnyfsn gfscsephdt elffaviyla pgdyhhfhsp vdwvckvrrh 361 fpgdlfsvap yfqrnfpnlf vlnervallg swkygffsmt pvgatnvgsi klnfdqefvt 421 nsksdkhlep htcyqavyen askilggmpl vkgeemggfe lgstvvlcfe aptefkfdvr 481 vgdkvkmgqk lgiigkndlk // LOCUS NP_014231 259 aa linear PLN 30-JUN-2025 DEFINITION Fmp41p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014231 VERSION NP_014231.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183006.1 REFERENCE 1 (residues 1 to 259) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 259) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 259) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 259) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 259) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10380. Method: conceptual translation. FEATURES Location/Qualifiers source 1..259 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..259 /product="Fmp41p" /EC_number="5.3.2.2" /calculated_mol_wt="28661" Region 8..232 /region_name="YcgM" /note="2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]; COG0179" /db_xref="CDD:439949" CDS 1..259 /gene="FMP41" /locus_tag="YNL168C" /coded_by="NM_001183006.1:1..780" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:14576278|PMID:16823961]" /note="hypothetical protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:855553" /db_xref="SGD:S000005112" ORIGIN 1 msynylkaar kiicigrnya ahikelnnst pkqpffflkp tssivtplss slvkttrpan 61 stfnglnedg tnpgpifipr gvkvhheiel alivskhlsn vtkmkpeevy dsisgvalal 121 dltarnvqde akkkglpwti skgfdtfmpi saivsrekfs syksnlqdif rvkcsvngql 181 rqdggtnlml hplhkilqhi stmislepgd iiltgtpagv gelkpgdrvh cellqnndni 241 vdmnfecenr pgpyefret // LOCUS NP_014232 647 aa linear PLN 30-JUN-2025 DEFINITION Sko1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014232 VERSION NP_014232.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183005.1 REFERENCE 1 (residues 1 to 647) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 647) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 647) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 647) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10381. Method: conceptual translation. FEATURES Location/Qualifiers source 1..647 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..647 /product="Sko1p" /calculated_mol_wt="70061" Region <196..>228 /region_name="Aft1_HRA" /note="Aft1 HRA domain; pfam11786" /db_xref="CDD:371723" Region 431..482 /region_name="bZIP_ATF2" /note="Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain; cd14687" /db_xref="CDD:269835" Region 431..482 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269835" Site order(432,436,438..440,443,445..447,449..451) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269835" CDS 1..647 /gene="SKO1" /locus_tag="YNL167C" /gene_synonym="ACR1" /coded_by="NM_001183005.1:1..1944" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11113177|PMID:11500510|PMID:12086627|PMID:1437546|PM ID:9858577|PMID:1448073]" /experiment="EXISTENCE:direct assay:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:1448073|PMID:1437546|PMID:9858577|PMID:11113177]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:12086627]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11500510]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11500510]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12086627]" /experiment="EXISTENCE:direct assay:GO:0051019 mitogen-activated protein kinase binding [PMID:11230135]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11230135|PMID:11500510]" /experiment="EXISTENCE:direct assay:GO:0071470 cellular response to osmotic stress [PMID:12086627]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9858577]" /experiment="EXISTENCE:genetic interaction:GO:0003714 transcription corepressor activity [PMID:11230135]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11230135|PMID:11113177]" /experiment="EXISTENCE:genetic interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11230135]" /experiment="EXISTENCE:genetic interaction:GO:0071470 cellular response to osmotic stress [PMID:11113177|PMID:11230135]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11230135|PMID:11113177|PMID:9858577|PMID:1448073|PMI D:1437546|PMID:10825197]" /experiment="EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11113177]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:12086627]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:9858577|PMID:11113177|PMID:1448073|PMID:1437546]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:12086627]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:11230135]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11230135|PMID:12086627|PMID:11113177|PMID:10825197]" /experiment="EXISTENCE:mutant phenotype:GO:0051019 mitogen-activated protein kinase binding [PMID:12086627]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11230135]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:12086627|PMID:11230135|PMID:11113177|PMID:10825197]" /note="Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses" /db_xref="GeneID:855554" /db_xref="SGD:S000005111" ORIGIN 1 msseersrqp stvstfdlep npfeqsfass kkalslpgti shpslpkels rnnststitq 61 hsqrsthsln sipeengnst vtdnsnhndv kkdspsflpg qqrptiispp iltpggskrl 121 pplllspsil yqansttnps qnshsvsvsn snpsaigvss tsgslypnss spsgtslirq 181 prnsnvttsn sgngfptnds qmpgfllnls ksgltpnesn irtgltpgil tqsynypvlp 241 sinkntitgs knvnksvtvn gsienhphvn imhptvngtp ltpglsslln lpstgvlanp 301 vfkstpttnt tdgtvnnsis nsnfspntst kaavkmdnpa efnaiehsah nhkenenltt 361 qienndqfnn ktrkrkrrms stsstskasr knsisrknsa vttapaqkdd vennkisnnv 421 tldeneeqer krkeflernr vaaskfrkrk keyikkiend lqfyeseydd ltqvigklcg 481 iipssssnsq fnvnvstpss ssppstslia llessisrsd yssamsvlsn mkqlicetnf 541 yrrggknprd dmdgqedsfn kdtnvvksen agypsvnsrp iildkkysln sganisksnt 601 ttnnvgnsaq niinscysvt nplvinansd thdtnkhdvl stlphnn // LOCUS NP_014233 448 aa linear PLN 30-JUN-2025 DEFINITION Bni5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014233 VERSION NP_014233.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183004.1 REFERENCE 1 (residues 1 to 448) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 448) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 448) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 448) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 448) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10382. Method: conceptual translation. FEATURES Location/Qualifiers source 1..448 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..448 /product="Bni5p" /calculated_mol_wt="49563" CDS 1..448 /gene="BNI5" /locus_tag="YNL166C" /coded_by="NM_001183004.1:1..1347" /experiment="EXISTENCE:direct assay:GO:0000144 cellular bud neck septin ring [PMID:12215547]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:12215547]" /experiment="EXISTENCE:genetic interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:25971666]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:12215547]" /experiment="EXISTENCE:mutant phenotype:GO:0072741 protein localization to cell division site [PMID:21173112]" /experiment="EXISTENCE:physical interaction:GO:0032035 myosin II tail binding [PMID:21173112]" /note="Linker protein responsible for recruitment of myosin to the bud neck; interacts with the C-terminal extensions of septins Cdc11p and Shs1p and binds Myo1p to promote cytokinesis" /db_xref="GeneID:855555" /db_xref="SGD:S000005110" ORIGIN 1 mgldqdkikk rlsqieidin qmnqmidenl qlvepaedea vednvkdtgv vdavkvaeta 61 lfsgndgads npgdsaqvee hktaqvhipt eneankstdd psqlsvtqpf iakeqithta 121 iaigdsynsf vansagneka kdsctenked gtvnidqnrg eadveiienn ddewedeksd 181 veegrvdkgt eenseiesfk spmpqnntlg genkldaelv ldkfssankd ldiqpqtivv 241 ggdneynhes srladqtphd dnsencpnrs ggstpldsqt kifipkknsk edgtninhfn 301 sdgdgqkkma nfetrrptnp frvisvssns nsrngsrkss lnkydspvss pitsaselgs 361 iaklekrhdy lsmkciklqk eidylnkmna qgslsmedgk rlhravvklq eyldkktkek 421 yevgvllsrh lrkqidrgen gqfwigtk // LOCUS NP_014234 406 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL165W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014234 VERSION NP_014234.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183003.3 REFERENCE 1 (residues 1 to 406) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 406) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 406) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 406) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10383. On Jul 30, 2012 this sequence version replaced NP_014234.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..406 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..406 /product="uncharacterized protein" /calculated_mol_wt="46046" CDS 1..406 /locus_tag="YNL165W" /coded_by="NM_001183003.3:1..1221" /note="hypothetical protein; YNL165W is not an essential gene" /db_xref="GeneID:855556" /db_xref="SGD:S000005109" ORIGIN 1 mdrvrslign rrgrrhnrqh ppyphsgsps tvnllgangy gddqstifar enesletsan 61 egddsadaat lntavsegst igdlqrqgyv nraprftser ampfvsvllq rgffafpsee 121 slqlflhnkr kldnidpkrg lglplfhais lnlvkslfsd qntpvmriyk yvmidsqcdk 181 pplnsevvsr inenvsiyky efctilkkme shnfssrveh dfifhrkdep dvhipminyn 241 qrknadtaih glnlrwygtt slaspfgsns inllvlddtm asymnqqtie efdsysrsrp 301 trplgylpvw arytddkvsv ipkkrtlrva tlylqetdsf ddgssltstn ytemgsniie 361 nvpwdsqilt cmcmllheye srkekrhtaw gssttymlng pagllm // LOCUS NP_014235 351 aa linear PLN 30-JUN-2025 DEFINITION Ibd2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014235 VERSION NP_014235.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183002.1 REFERENCE 1 (residues 1 to 351) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 351) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 351) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 351) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 351) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10384. Method: conceptual translation. FEATURES Location/Qualifiers source 1..351 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..351 /product="Ibd2p" /calculated_mol_wt="39885" CDS 1..351 /gene="IBD2" /locus_tag="YNL164C" /coded_by="NM_001183002.1:1..1056" /experiment="EXISTENCE:genetic interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:12072457]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:12072457]" /note="Component of the BUB2-dependent spindle checkpoint pathway; interacts with Bfa1p and functions upstream of Bub2p and Bfa1p" /db_xref="GeneID:855557" /db_xref="SGD:S000005108" ORIGIN 1 mtptnqssgt tnasvevlse dgpmpinvmm qegvkaltki lsnqlqdrqa fqnaphamqf 61 virnggkals narleelkda lpkmdslsle delakidgqs ayhidsaeek etfeskigqi 121 asrnsadfii eedlqnildd dlkdselnld geeaeiifdy esqeldtpdg igekisqmie 181 svlpggfgse eqgglrtvtn vedldvaeev tdidhdtvda arlhgdgqhs issrkhsrsk 241 nskknghvrr hdfydesrdh ksccphhhye nlsklrnyyy hdfeyisrte nrvpdfsvlv 301 nesspmclfc eyymvfgepp rnmikwynrt fgynrmpnpp rdeqdsrkrn r // LOCUS NP_014236 1110 aa linear PLN 30-JUN-2025 DEFINITION GTPase RIA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014236 VERSION NP_014236.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183001.1 REFERENCE 1 (residues 1 to 1110) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1110) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1110) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1110) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1110) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10385. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1110 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1110 /product="GTPase RIA1" /calculated_mol_wt="124333" Region 1..1091 /region_name="PRK13351" /note="elongation factor G-like protein; cl46912" /db_xref="CDD:481252" CDS 1..1110 /gene="RIA1" /locus_tag="YNL163C" /gene_synonym="EFL1" /coded_by="NM_001183001.1:1..3333" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11779510]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11779510]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0042256 cytosolic ribosome assembly [PMID:11779510]" /note="Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, a guanine nucleotide exchange factor (GEF), promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes" /db_xref="GeneID:855558" /db_xref="SGD:S000005107" ORIGIN 1 mprvesetyk rlqndpscir nicivahvdh gktslsdsll asngiisqrl agkirfldar 61 pdeqlrgitm essaislyfr vlrkqegsde plvsehlvnl idspghidfs sevsaasrlc 121 dgavvlvdvv egvcsqtvtv lrqcwteklk pilvlnkidr litelqltpq eayihlskvi 181 eqvnsvigsf fanerqlddl fwreqlekne naeyiekdds giyfnptdnn vifasaidgw 241 gfnigqlakf yeqklgakre nlqkvlwgdf ymdpktkkii nnkglkgrsl kplftslile 301 niwkiyqnii tsrdsemvek iaktlnikll ardlrskddk qllrtimgqw lpvstavllt 361 vieklpsple sqtdrlntil vsesdtaamd prllkamktc dkegpvsayv skmlsipree 421 lpveskrias sdelmersrk areealnaak hagmvenmam mdlndnsknt sdlykrakdt 481 vmtpevgeqt kpkpsrnndv fcvvsepssa ldlefeyege ddsdsqdnfg ldfvptdidp 541 ndplssmfey eeedpllesi kqisedvnde vddifdekee clvafariys gtlrvgqeis 601 vlgpkydpkc peehietaii thlylfmgke lvpldvcpsg nivgirglag kvlksgtlie 661 kgvqgvnlag vnfhftpivr vavepanpve msklvrglkl ldqadpcvht yventgehil 721 ctagelhler clkdlterfa gieithsepa ipyretflsa sdmnppqnsq lgrgvhelll 781 sqykitfrtf plsgkvtdfl sqhqnsikni lktstssmdp viestgssfl dkksllvafe 841 evinqeeksr ellsgfkvkl agfgpsrvgc nillsqdnll gslfegtpaa feysdsikng 901 fqlavsegpl anepvqgmcv lvesvhkmsq deiesiedpr yqqhivdlsg rlitstrdai 961 heafldwspr imwaiyscdi qtsvdvlgkv yavilqrhgk iiseemkegt pffqieahvp 1021 vveafglsed irkrtsgaaq pqlvfsgfec idldpfwvpt teeeleelgd tadreniark 1081 hmnairrrkg lfieekvven aekqrtlkkn // LOCUS NP_076906 72 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL162W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_076906 VERSION NP_076906.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184490.1 REFERENCE 1 (residues 1 to 72) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 72) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 72) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 72) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10386. Method: conceptual translation. FEATURES Location/Qualifiers source 1..72 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..72 /product="uncharacterized protein" /calculated_mol_wt="8133" CDS 1..72 /locus_tag="YNL162W-A" /coded_by="NM_001184490.1:1..219" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; identified by homology" /db_xref="GeneID:855559" /db_xref="SGD:S000007624" ORIGIN 1 msdkpdsqvf cpncnerlqk clvqqnyaii icpslvcgyp fnqrevlenl tyvddndvlk 61 vakkrlssrs kp // LOCUS NP_014237 106 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL42 RPL42A [Saccharomyces cerevisiae S288C]. ACCESSION NP_014237 VERSION NP_014237.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183000.1 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10387. On Jan 7, 2000 this sequence version replaced NP_014237.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..106 /product="60S ribosomal protein eL42 RPL42A" /calculated_mol_wt="12080" Region 1..86 /region_name="PTZ00157" /note="60S ribosomal protein L36a; Provisional" /db_xref="CDD:240296" CDS 1..106 /gene="RPL42A" /locus_tag="YNL162W" /coded_by="NM_001183000.1:1..321" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L42A; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42A has a paralog, RPL42B, that arose from the whole genome duplication" /db_xref="GeneID:855560" /db_xref="SGD:S000005106" ORIGIN 1 mvnvpktrkt yckgktcrkh tqhkvtqyka gkaslfaqgk rrydrkqsgf ggqtkpvfhk 61 kakttkkvvl rlecvkcktr aqltlkrckh felggekkqk gqalqf // LOCUS NP_014238 756 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase CBK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014238 VERSION NP_014238.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182999.3 REFERENCE 1 (residues 1 to 756) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 756) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 756) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 756) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 756) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 756) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 756) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 756) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10388. On Jul 30, 2012 this sequence version replaced NP_014238.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..756 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..756 /product="serine/threonine protein kinase CBK1" /EC_number="2.7.11.1" /calculated_mol_wt="86815" Region 269..341 /region_name="MobB_CBK1" /note="Mob-binding domain found in cell wall biosynthesis kinase CBK1 and similar proteins; cd21773" /db_xref="CDD:439268" Site order(270..272,274..276,279,282..283,286..287,289..291, 293..294,297..298,301,304,308,312,329,333,336..338, 340..341) /site_type="other" /note="Mob binding site [polypeptide binding]" /db_xref="CDD:439268" Region 350..748 /region_name="STKc_NDR_like_fungal" /note="Catalytic domain of Fungal Nuclear Dbf2-Related kinase-like Serine/Threonine Kinases; cd05629" /db_xref="CDD:270778" Site order(358..362,366,379,381,413,429..430,432,436,438,475, 477,479..480,482,492..493,496,571..576,603,609,612) /site_type="active" /db_xref="CDD:270778" Site order(358..362,366,379,381,413,430..432,436,475,477, 479..480,482,492..493) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270778" Site order(362,436,438,475,477,479,496,571..576,603,609,612) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270778" Site order(492..504,567..576) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270778" Site 739..744 /site_type="other" /note="hydrophobic motif (HM)" /db_xref="CDD:270778" CDS 1..756 /gene="CBK1" /locus_tag="YNL161W" /coded_by="NM_001182999.3:1..2271" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10970846]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:18715118]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11747810|PMID:12196508]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10970846|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12196508]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10970846|PMID:11747810|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:12196508|PMID:11747810|PMID:10970846|P MID:11259593]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:10970846]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:11747810|PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0007118 budding cell apical bud growth [PMID:12972564|PMID:11259593]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:19962308]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:12196508|PMID:11747810]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:11259593|PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0007163 establishment or maintenance of cell polarity [PMID:12196508]" /experiment="EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:11259593]" /experiment="EXISTENCE:mutant phenotype:GO:0050708 regulation of protein secretion [PMID:30455324]" /note="Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress" /db_xref="GeneID:855561" /db_xref="SGD:S000005105" ORIGIN 1 mynsstnhhe gaptsghgyy msqqqdqqhq qqqqyanemn pyqqiprppa agfssnymke 61 qgshqslqeh lqretgnlgs gftdvpalny patppphnny aasnqmintp ppsmgglyrh 121 nnnsqsmvqn gngsgnaqlp qlspgqysie seynqnlngs sssspfhqpq tlrsngsyss 181 glrsvksfqr lqqeqenvqv qqqlsqaqqq nsrqqqqqlq yqqqqqqqqq qqhmqiqqqq 241 qqqqqqqqsq spvqsgfnng tisnymyfer rpdlltkgtq dkaaavklki enfyqssvky 301 aiernerrve leteltshnw seerksrqls slgkkesqfl rlrrtrlsle dfhtvkvigk 361 gafgevrlvq kkdtgkiyam ktllksemyk kdqlahvkae rdvlagsdsp wvvslyysfq 421 daqylylime flpggdlmtm lirwqlfted vtrfymaeci laietihklg fihrdikpdn 481 ilidirghik lsdfglstgf hkthdsnyyk kllqqdeatn giskpgtyna nttdtankrq 541 tmvvdsislt msnrqqiqtw rksrrlmays tvgtpdyiap eiflyqgygq ecdwwslgai 601 myecligwpp fcsetpqety rkimnfeqtl qfpddihisy eaedlirrll thadqrlgrh 661 ggadeikshp ffrgvdwnti rqveapyipk lssitdtrff ptdelenvpd spamaqaakq 721 reqmtkqggs apvkedlpfi gytysrfdyl trknal // LOCUS NP_014239 354 aa linear PLN 30-JUN-2025 DEFINITION Ygp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014239 VERSION NP_014239.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182998.1 REFERENCE 1 (residues 1 to 354) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 354) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 354) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 354) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10389. Method: conceptual translation. FEATURES Location/Qualifiers source 1..354 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..354 /product="Ygp1p" /calculated_mol_wt="37197" Region 102..338 /region_name="L-asparaginase_like" /note="Bacterial L-asparaginases and related enzymes; cl00216" /db_xref="CDD:469665" CDS 1..354 /gene="YGP1" /locus_tag="YNL160W" /coded_by="NM_001182998.1:1..1065" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:19129178]" /experiment="EXISTENCE:direct assay:GO:0070726 cell wall assembly [PMID:10234784]" /note="Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; protein demonstrates amyloid properties in vivo; YGP1 has a paralog, SPS100, that arose from the whole genome duplication" /db_xref="GeneID:855562" /db_xref="SGD:S000005104" ORIGIN 1 mkfqvvlsal lacssavvas pienlfkyra vkashsknin stlpawngsn ssnvtyangt 61 nsttntttae ssqlqiivtg gqvpitnssl thtnytrlfn sssalnitel ynvarvvnet 121 iqdkssagav vvanakslea vsfffsiifd tekpivvted sayaipvann knatkrgvls 181 vtsdklvysg vftpptacsy gaglpvaivd dqdevkwffd askptlissd siirkeysnf 241 ttpyglleng vpivpivydg gyssslidsl ssavqglvvv ssgstnstss tiesteipvv 301 yaqantplnf idnkdvpkna vgagylspik aqillsiaav ngvtsksale sifp // LOCUS NP_014240 289 aa linear PLN 30-JUN-2025 DEFINITION Asi2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014240 VERSION NP_014240.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182997.1 REFERENCE 1 (residues 1 to 289) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 289) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 289) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 289) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10390. Method: conceptual translation. FEATURES Location/Qualifiers source 1..289 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..289 /product="Asi2p" /calculated_mol_wt="32855" CDS 1..289 /gene="ASI2" /locus_tag="YNL159C" /coded_by="NM_001182997.1:1..870" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:17085444]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0097658 Asi complex [PMID:25236469]" /experiment="EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11454748]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25236469]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:25253722]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:17085444]" /note="Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; the Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and inner for ubiquitin-mediated degradation; acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids" /db_xref="GeneID:855563" /db_xref="SGD:S000005103" ORIGIN 1 marpqnhrrs nwterddndd ylfqrflees etrhsrepsp vteqsqqelq qdvqqaidgi 61 fnslrrnmss tsninraanm dattngnggi nadtiratna ntadspftar qqsplrtflr 121 nlfildyfig lilfpfsvyn ilrsgfnsmt fsendfiiei vgywkfakif gsggttliay 181 kdtgklgllg kfhniivfys spvikhimks rdgnepnlnw irlmfakafe lfvkvstili 241 ylaygvsgtv ymvtagfffv lcllftvirr ykgvhrmlvs qritgpgvf // LOCUS NP_014241 198 aa linear PLN 30-JUN-2025 DEFINITION Pga1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014241 VERSION NP_014241.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182996.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10391. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..198 /product="Pga1p" /calculated_mol_wt="22252" Region 14..189 /region_name="Pga1" /note="GPI-Mannosyltransferase II co-activator; pfam10333" /db_xref="CDD:370985" CDS 1..198 /gene="PGA1" /locus_tag="YNL158W" /coded_by="NM_001182996.1:1..597" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17615295]" /experiment="EXISTENCE:genetic interaction:GO:0000030 mannosyltransferase activity [PMID:17615295]" /experiment="EXISTENCE:genetic interaction:GO:0031501 mannosyltransferase complex [PMID:17615295]" /experiment="EXISTENCE:mutant phenotype:GO:0000030 mannosyltransferase activity [PMID:17615295]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:17615295]" /experiment="EXISTENCE:physical interaction:GO:0031501 mannosyltransferase complex [PMID:17615295]" /note="Essential component of GPI-mannosyltransferase II; complex is responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interactions with secretory pathway genes" /db_xref="GeneID:855564" /db_xref="SGD:S000005102" ORIGIN 1 mvrpqnvhwf iativffigf vhantesily kvphnfplkk prdsstyard vnlissisls 61 geamsqitie anttdlelhn ttyieladlq rdetyqikvc wsaihpisin nlqtitiprf 121 tefqgtksdy arilvtfqvl sdsypseham vpiqvslitt rlgipvdiyp tlivmvllva 181 glvvtraphv lndlllkf // LOCUS NP_014242 168 aa linear PLN 30-JUN-2025 DEFINITION phosphatase regulator [Saccharomyces cerevisiae S288C]. ACCESSION NP_014242 VERSION NP_014242.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182995.1 REFERENCE 1 (residues 1 to 168) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 168) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 168) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 168) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10392. Method: conceptual translation. FEATURES Location/Qualifiers source 1..168 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..168 /product="phosphatase regulator" /calculated_mol_wt="17920" Region 27..109 /region_name="Endosulfine" /note="cAMP-regulated phosphoprotein/endosulfine conserved region; pfam04667" /db_xref="CDD:398375" CDS 1..168 /gene="IGO1" /locus_tag="YNL157W" /coded_by="NM_001182995.1:1..507" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:20471941]" /experiment="EXISTENCE:direct assay:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:23273919|PMID:23861665]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:20471941]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:23861665]" /experiment="EXISTENCE:genetic interaction:GO:0048255 mRNA stabilization [PMID:20471941]" /experiment="EXISTENCE:genetic interaction:GO:1900152 negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:20471941]" /experiment="EXISTENCE:genetic interaction:GO:1901992 positive regulation of mitotic cell cycle phase transition [PMID:23861665]" /experiment="EXISTENCE:genetic interaction:GO:1903452 positive regulation of G1 to G0 transition [PMID:23273919|PMID:20471941]" /experiment="EXISTENCE:mutant phenotype:GO:0004865 protein serine/threonine phosphatase inhibitor activity [PMID:23273919]" /note="Protein required for initiation of the G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylation (S63) by Rim15p increases interaction with and inhibition of PP2A-Cdc55 for timely mitotic progression; can also activate PP2A-Cdc55 complexes and influence Cdc55p localization along with Igo2p; GFP protein localizes to the cytoplasm and nucleus; IGO1 has a paralog, IGO2, that arose from the whole genome duplication" /db_xref="GeneID:855565" /db_xref="SGD:S000005101" ORIGIN 1 msnenlspns snpdltklnn gesgtidtsk fspnemklyk mygklpskkd ifkhtmqkrk 61 yfdsgdyalq kagiqnndpi nygknnlplt npsklredii krristcpst astagvvdna 121 tliqkegsis sgppssnngt igggstsstp vgnhssssss lytespir // LOCUS NP_014243 299 aa linear PLN 30-JUN-2025 DEFINITION Nsg2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014243 VERSION NP_014243.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182994.3 REFERENCE 1 (residues 1 to 299) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 299) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 299) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 299) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10393. On Jul 30, 2012 this sequence version replaced NP_014243.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..299 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..299 /product="Nsg2p" /calculated_mol_wt="33536" Region 116..296 /region_name="INSIG" /note="Insulin-induced protein (INSIG); pfam07281" /db_xref="CDD:462131" CDS 1..299 /gene="NSG2" /locus_tag="YNL156C" /coded_by="NM_001182994.3:1..900" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0016126 sterol biosynthetic process [PMID:16270032]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:16270032]" /note="Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins; NSG2 has a paralog, NSG1, that arose from the whole genome duplication" /db_xref="GeneID:855566" /db_xref="SGD:S000005100" ORIGIN 1 manrgepdpk kstesicslt kpqlyslydd dvvrsednei yeelkrsvsi dstkysrdqt 61 idstfylahk vggslprntv ssnnlerils assihenfps rtrqtrqnil hylqavlils 121 lsgfayhels rnlhdnhllh pdfasrplll gvklcnwlsn gvlpnwlgyg vegllfgsvv 181 pildnifqte vvkssvhhds ltsvirsina mlgvtfgirk iqwnsslqaa gawgllniil 241 wlffdgsism lmscicigvg cciscykdii dgsqflyfmd fyflgslmfg klgrylysh // LOCUS NP_001418071 74 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL155C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001418071 VERSION NP_001418071.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001431142.1 REFERENCE 1 (residues 1 to 74) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 74) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 74) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 74) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DBA54442. Method: conceptual translation. FEATURES Location/Qualifiers source 1..74 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..74 /product="uncharacterized protein" /calculated_mol_wt="8432" CDS 1..74 /locus_tag="YNL155C-A" /coded_by="NM_001431142.1:1..225" /note="hypothetical protein; well conserved across Saccharomyces species; added to genome annotation based on proteomic, translation, and evolutionary evidence" /db_xref="GeneID:91000626" /db_xref="SGD:S000350099" ORIGIN 1 miglivvpil faikgivvgv qkvkkkfgkh sntkdqkedk dedkrqsisq rkqhtewpie 61 enriqrrapn qsal // LOCUS NP_014244 274 aa linear PLN 30-JUN-2025 DEFINITION Cuz1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014244 VERSION NP_014244.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182993.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10394. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..274 /product="Cuz1p" /calculated_mol_wt="31386" Region 18..55 /region_name="ZnF_AN1" /note="AN1-like Zinc finger; smart00154" /db_xref="CDD:197545" CDS 1..274 /gene="CUZ1" /locus_tag="YNL155W" /coded_by="NM_001182993.1:1..825" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0070628 proteasome binding [PMID:24121501|PMID:24297164]" /experiment="EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:24121501]" /experiment="EXISTENCE:genetic interaction:GO:0071243 cellular response to arsenic-containing substance [PMID:24297164]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:24121501]" /experiment="EXISTENCE:mutant phenotype:GO:0071243 cellular response to arsenic-containing substance [PMID:24297164]" /experiment="EXISTENCE:physical interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:24121501]" /note="Protein involved in Ub-proteasome dependent catabolism; interacts with Cdc48p and the proteasome, protecting cells from arsenite-induced proteotoxicity through stress granule (SG) clearance; contains a PACE promoter element; co-regulated with proteasome subunit genes; contains an AN1-type zinc finger, a DHHC domain and a UBL fold; complements SG clearance in arsenite treated HeLa cells depleted of ZFAND1, a human ortholog linked to cancer; protein abundance increases under DNA replication stress" /db_xref="GeneID:855567" /db_xref="SGD:S000005099" ORIGIN 1 msaaieketg mldvgkhcay crqldflpfh csfcnedfcs nhrlkedhhc rwlleheevh 61 ktekspsksr dgsssndeay fksllperas vriqrvsetr eplrgsntak vsstlnsktl 121 dkifkffqrn ekrksnnksk knfgsssnki iqlanlkkia kgdpkipmqn riyiwcylvd 181 gdetdiaked trmplyinkm wpvgramdyl siqlnvksst ltnsssndkf qlcklkegkq 241 vsfynigasl rvtneikdld tlylvhnnad eksn // LOCUS NP_014245 546 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase YCK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014245 VERSION NP_014245.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182992.1 REFERENCE 1 (residues 1 to 546) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 546) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 546) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 546) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10395. Method: conceptual translation. FEATURES Location/Qualifiers source 1..546 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..546 /product="serine/threonine protein kinase YCK2" /EC_number="2.7.11.1" /calculated_mol_wt="61948" Region 75..351 /region_name="STKc_CK1_fungal" /note="Catalytic domain of the Serine/Threonine protein kinase, Fungal Casein Kinase 1 homolog 1; cd14127" /db_xref="CDD:271029" Site order(82..88,90,103,105,149..153,155,157,195,197,199..200, 202,218,221,244..247) /site_type="active" /db_xref="CDD:271029" Site order(82..88,90,103,105,149..153,197,199..200,202,217..218) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271029" Site order(86,155,157,195,197,199,221,244..247) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271029" Site 217..247 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271029" CDS 1..546 /gene="YCK2" /locus_tag="YNL154C" /coded_by="NM_001182992.1:1..1641" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8474447]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8034689|PMID:1627830|PMID:12469340|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:10198058]" /experiment="EXISTENCE:direct assay:GO:0005937 mating projection [PMID:10198058]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000902 cell morphogenesis [PMID:8474447]" /experiment="EXISTENCE:genetic interaction:GO:0010255 glucose mediated signaling pathway [PMID:27630263]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:10198058]" /experiment="EXISTENCE:mutant phenotype:GO:0009749 response to glucose [PMID:14755054]" /note="Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK2 has a paralog, YCK1, that arose from the whole genome duplication" /db_xref="GeneID:855568" /db_xref="SGD:S000005098" ORIGIN 1 msqvqsplta tnsglavnnn tmnsqmpnrs nvrlvngtlp pslhvssnln hntgnssasy 61 sgsqsrddst ivglhykigk kigegsfgvl fegtnmingl pvaikfeprk teapqlkdey 121 rtykilagtp gipqeyyfgq eglhnilvid llgpsledlf dwcgrrfsvk tvvqvavqmi 181 tliedlhahd liyrdikpdn fligrpgqpd ankvhlidfg makqyrdpkt kqhipyrekk 241 slsgtaryms inthlgreqs rrddmeamgh vffyflrgql pwqglkapnn kqkyekigek 301 krltnvydla qglpiqfgry leivrnlsfe etpdyegyrm lllsvlddlg etadgqydwm 361 klnggrgwdl sinkkpnlhg yghpnppnek skrhrsknhq ysspdhhhhy nqqqqqqqaq 421 aqaqaqaqak vqqqqlqqaq aqqqanryql qpddshydee reaskldpts yeayqqqtqq 481 kyaqqqqkqm qqkskqfant gangqtnkyp ynaqptande qnaknaaqdr nsnksskgff 541 sklgcc // LOCUS NP_014246 129 aa linear PLN 30-JUN-2025 DEFINITION tubulin-binding prefolding complex subunit GIM3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014246 VERSION NP_014246.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182991.1 REFERENCE 1 (residues 1 to 129) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 129) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 129) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 129) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10396. Method: conceptual translation. FEATURES Location/Qualifiers source 1..129 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..129 /product="tubulin-binding prefolding complex subunit GIM3" /calculated_mol_wt="15049" Region 18..120 /region_name="Prefoldin_4" /note="prefoldin subunit 4; cd23165" /db_xref="CDD:467481" Site order(18,20..23,26..27,30,97,100..101,103..104,107..108, 110..112,114..116,118..120) /site_type="other" /note="prefoldin/TRiC interface [polypeptide binding]" /db_xref="CDD:467481" Region 18..59 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467481" Site order(55..56,60,64,66..75,81,85) /site_type="other" /note="prefoldin oligomer interface [polypeptide binding]" /db_xref="CDD:467481" Region 79..120 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:467481" CDS 1..129 /gene="GIM3" /locus_tag="YNL153C" /gene_synonym="PFD4" /coded_by="NM_001182991.1:1..390" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9463374]" /experiment="EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:9463374]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9463374]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24068951]" /experiment="EXISTENCE:mutant phenotype:GO:0071629 cytoplasm protein quality control by the ubiquitin-proteasome system [PMID:27448207]" /experiment="EXISTENCE:physical interaction:GO:0016272 prefoldin complex [PMID:9463374]" /note="Subunit of the heterohexameric cochaperone prefoldin complex; prefoldin binds specifically to cytosolic chaperonin and transfers target proteins to it; prefoldin complex also localizes to chromatin of actively transcribed genes in the nucleus and facilitates transcriptional elongation" /db_xref="GeneID:855569" /db_xref="SGD:S000005097" ORIGIN 1 mellpqgqrn ntqvtfedqq kinefsklim rkdaiaqels lqreekeyld dvsleielid 61 edepvqykvg dlfifmkqsk vtaqlekdae rldnkietle dkqrdidsrl dalkailyak 121 fgdninler // LOCUS NP_014247 409 aa linear PLN 30-JUN-2025 DEFINITION Inn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014247 VERSION NP_014247.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182990.1 REFERENCE 1 (residues 1 to 409) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 409) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 409) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 409) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10397. Method: conceptual translation. FEATURES Location/Qualifiers source 1..409 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..409 /product="Inn1p" /calculated_mol_wt="46095" Region 11..133 /region_name="C2_fungal_Inn1p-like" /note="C2 domain found in fungal Ingression 1 (Inn1) proteins; cd08681" /db_xref="CDD:176063" CDS 1..409 /gene="INN1" /locus_tag="YNL152W" /coded_by="NM_001182990.1:1..1230" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:18344988]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:genetic interaction:GO:0030234 enzyme regulator activity [PMID:22956544]" /experiment="EXISTENCE:genetic interaction:GO:1990344 secondary cell septum biogenesis [PMID:19528296]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:22956544|PMID:18344988]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:18439903]" /experiment="EXISTENCE:mutant phenotype:GO:1990344 secondary cell septum biogenesis [PMID:19528296]" /experiment="EXISTENCE:physical interaction:GO:0044697 HICS complex [PMID:22623719]" /note="Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis" /db_xref="GeneID:855570" /db_xref="SGD:S000005096" ORIGIN 1 mseevwngnq gilsvyvska rdlpnlnkld kqnvmlrlri ahmtrasntl hragqnpvfh 61 ylekfditpe ikplmyvevy cdrrkksplp igrceidlln airadpkegy ctwyelkrsg 121 defagtifie ltftpkvprl nrddlnkemd rldssmamrp ipplptesey dyvhgstmrq 181 itpqcvstsh edkdegqpyr ngnvfsmssk sdtavlansn dpiilpptfs asmgttstle 241 tndtaisnts ntkfhfanlr klkekinifk npdsstnncq nesnkvdiea lqkaigvtsl 301 sydedddddd endafysssh rvshnynqpp lppiptrddm snysssrntp lvrrdrpsrl 361 dssspnshph psglnspklp plpttsnsnf nsrknsmspt rkrppprls // LOCUS NP_014248 251 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase III subunit C31 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014248 VERSION NP_014248.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182989.3 REFERENCE 1 (residues 1 to 251) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 251) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 251) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 251) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10398. On Jul 30, 2012 this sequence version replaced NP_014248.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..251 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..251 /product="DNA-directed RNA polymerase III subunit C31" /calculated_mol_wt="27593" Region 19..193 /region_name="RNA_pol_3_Rpc31" /note="DNA-directed RNA polymerase III subunit Rpc31; pfam11705" /db_xref="CDD:463324" CDS 1..251 /gene="RPC31" /locus_tag="YNL151C" /gene_synonym="ACP2; RPC8" /coded_by="NM_001182989.3:1..756" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0006384 transcription initiation at RNA polymerase III promoter [PMID:7835345]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:2201900]" /note="RNA polymerase III subunit C31" /db_xref="GeneID:855571" /db_xref="SGD:S000005095" ORIGIN 1 mssyrggsrg ggsnymsnlp fglgygdvgk nhitefpsip lpingpitnk erslavkyin 61 fgktvkdgpf ytgsmsliid qqensksgkr kpniildedd tndgierysd kylkkrkigi 121 siddhpynln lfpnelynvm ginkkkllai skfnnaddvf tgtglqdeni glsmlaklke 181 laedvddast gdgaakgskt gegedddlad ddfeededee ddddynaeky fnngddddyg 241 deedpneeaa f // LOCUS NP_014250 129 aa linear PLN 30-JUN-2025 DEFINITION Pga2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014250 VERSION NP_014250.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182987.1 REFERENCE 1 (residues 1 to 129) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 129) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 129) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 129) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10399. Method: conceptual translation. FEATURES Location/Qualifiers source 1..129 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..129 /product="Pga2p" /calculated_mol_wt="14922" Region 16..128 /region_name="PGA2" /note="Protein trafficking PGA2; pfam07543" /db_xref="CDD:369416" CDS 1..129 /gene="PGA2" /locus_tag="YNL149C" /coded_by="NM_001182987.1:1..390" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762|PMID:14690591]" /experiment="EXISTENCE:mutant phenotype:GO:0015031 protein transport [PMID:16943325]" /note="Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect" /db_xref="GeneID:855573" /db_xref="SGD:S000005093" ORIGIN 1 msevaetwvd twmaklvnyd ykhfirlvii vggylllrni asrelakkql aaqvekdkrd 61 keekrskdli dkpddaatae ttsfgwgkkt rrrvkrqqel fenaleeakr rnqgldpdsd 121 adieellee // LOCUS NP_014251 254 aa linear PLN 30-JUN-2025 DEFINITION Alf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014251 VERSION NP_014251.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182986.1 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10400. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..254 /product="Alf1p" /calculated_mol_wt="28223" Region 2..67 /region_name="Ubl1_cv_Nsp3_N-like" /note="first ubiquitin-like (Ubl) domain located at the N-terminus of coronavirus SARS-CoV non-structural protein 3 (Nsp3) and related proteins; cl28922" /db_xref="CDD:475130" Region 163..229 /region_name="CAP_GLY" /note="CAP-Gly domain; pfam01302" /db_xref="CDD:460154" CDS 1..254 /gene="ALF1" /locus_tag="YNL148C" /coded_by="NM_001182986.1:1..765" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0007023 post-chaperonin tubulin folding pathway [PMID:9885248]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:9885248]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9885248]" /experiment="EXISTENCE:mutant phenotype:GO:0007023 post-chaperonin tubulin folding pathway [PMID:9885248]" /experiment="EXISTENCE:physical interaction:GO:0043014 alpha-tubulin binding [PMID:9885248]" /note="Alpha-tubulin folding protein; similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance" /db_xref="GeneID:855574" /db_xref="SGD:S000005092" ORIGIN 1 mvrvviesel vrtekelpns lklrqfkdrl yhvtgveped meivvkrqyd nkeiystkkg 61 gaysnededa nflkgeeeli vvvtdsnaqs isnqlatqae gipsmevise edylrrdqsv 121 lrwkmahgyg rfnaaqqsqr aalakqdeay areqltaaig rhcrvtvdgs apreailryv 181 gplpldvmgt wcgvefpeaa gkndgringv tlfgpvapgh gsfvrprave ilskdeesae 241 vedvhddves ddei // LOCUS NP_014252 115 aa linear PLN 30-JUN-2025 DEFINITION Sm-like protein LSM7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014252 VERSION NP_014252.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182985.1 REFERENCE 1 (residues 1 to 115) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 115) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 115) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 115) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10401. On Oct 15, 2007 this sequence version replaced NP_014252.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..115 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..115 /product="Sm-like protein LSM7" /calculated_mol_wt="12875" Region 24..115 /region_name="LSm7" /note="Like-Sm protein 7; cd01729" /db_xref="CDD:212476" Site order(28,30,33..34,39,41..43,46,48,53..60,62,87,89,91..104) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:212476" Site order(38..44,46..58,60..64) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212476" Site order(56,58,95) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:212476" Site 91..102 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212476" CDS 1..115 /gene="LSM7" /locus_tag="YNL147W" /coded_by="NM_001182985.1:1..348" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:10369684]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005688 U6 snRNP [PMID:10369684|PMID:10747033|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:18029398|PMID:15075370]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:18029398]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419]" /experiment="EXISTENCE:direct assay:GO:1990726 Lsm1-7-Pat1 complex [PMID:24139796]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10428970|PMID:11333229]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:10747033]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:19806183]" /experiment="EXISTENCE:physical interaction:GO:0005732 sno(s)RNA-containing ribonucleoprotein complex [PMID:15075370]" /note="Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress" /db_xref="GeneID:855575" /db_xref="SGD:S000005091" ORIGIN 1 mhqqhsksen kpqqqrkkfe gpkreaildl akykdskirv klmggklvig vlkgydqlmn 61 lvlddtveym snpddennte lisknarklg ltvirgtilv slssaegsdv lymqk // LOCUS NP_878152 64 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL146C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878152 VERSION NP_878152.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184663.1 REFERENCE 1 (residues 1 to 64) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 64) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 64) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 64) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 64) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10402. Method: conceptual translation. FEATURES Location/Qualifiers source 1..64 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..64 /product="uncharacterized protein" /calculated_mol_wt="7550" CDS 1..64 /locus_tag="YNL146C-A" /coded_by="NM_001184663.1:1..195" /note="hypothetical protein" /db_xref="GeneID:1466510" /db_xref="SGD:S000028851" ORIGIN 1 misvcfvfph slaldfksrc kknrtklcsa yyvsqvlric kempyrdlil fstvrkgvym 61 rlyy // LOCUS NP_014253 100 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL146W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014253 VERSION NP_014253.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182984.3 REFERENCE 1 (residues 1 to 100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 100) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10403. On Jul 30, 2012 this sequence version replaced NP_014253.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..100 /product="uncharacterized protein" /calculated_mol_wt="11756" CDS 1..100 /locus_tag="YNL146W" /coded_by="NM_001182984.3:1..303" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene" /db_xref="GeneID:855576" /db_xref="SGD:S000005090" ORIGIN 1 msntkhttsh hmelkriiil tllfilimli frnsvsfkmt fqellprfyk knsnsvsnnn 61 rpssifsenl vdfddvnmvd ktrlfiflff sfiitipfmv // LOCUS NP_014254 38 aa linear PLN 30-JUN-2025 DEFINITION mating pheromone a [Saccharomyces cerevisiae S288C]. ACCESSION NP_014254 VERSION NP_014254.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182983.1 REFERENCE 1 (residues 1 to 38) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 38) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 38) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 38) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 38) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 38) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 38) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 38) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10404. Method: conceptual translation. FEATURES Location/Qualifiers source 1..38 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..38 /product="mating pheromone a" /calculated_mol_wt="4098" Region 1..38 /region_name="MFA1_2" /note="Mating hormone A-factor 1_2; pfam17317" /db_xref="CDD:407425" CDS 1..38 /gene="MFA2" /locus_tag="YNL145W" /coded_by="NM_001182983.1:1..117" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:2046670]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3285180]" /experiment="EXISTENCE:mutant phenotype:GO:0000772 mating pheromone activity [PMID:3285180]" /note="Mating pheromone a-factor; made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1" /db_xref="GeneID:855577" /db_xref="SGD:S000005089" ORIGIN 1 mqpittastq atqkdkssek kdnyiikglf wdpacvia // LOCUS NP_014255 740 aa linear PLN 30-JUN-2025 DEFINITION Mpf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014255 VERSION NP_014255.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182982.1 REFERENCE 1 (residues 1 to 740) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 740) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 740) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 740) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 740) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 740) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 740) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 740) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10405. Method: conceptual translation. FEATURES Location/Qualifiers source 1..740 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..740 /product="Mpf1p" /calculated_mol_wt="84072" CDS 1..740 /gene="MPF1" /locus_tag="YNL144C" /coded_by="NM_001182982.1:1..2223" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0032473 cytoplasmic side of mitochondrial outer membrane [PMID:40175596]" /note="hypothetical protein; involved in the dual distribution of tail-anchored proteins such as Fis1p and Gem1p to mitochondria and peroxisomes; unstable protein that associates with the cytosolic face of the mitochondrial outer membrane; detected in highly purified mitochondria in high-throughput studies; contains a PH domain that impacts protein stability; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study" /db_xref="GeneID:855578" /db_xref="SGD:S000005088" ORIGIN 1 msssifemti dhdgmdstgl klsqtassis mgdeflcsst tsnsildspl pkvtfnhids 61 itdintnimn eivepqsgvd vdvadknvly cidpypvepp cydfanpskv irypiyehcr 121 pcltsvkpps ytpsvehytv vsmkmeklsp fenassrlwn nfilqinstq infysiddsl 181 trhiknyrgg dmfdhshhsk tasdrhhsar sllnafttks tyqfdkydke ricgeiarde 241 hkflsderlf ksyslqcakv glpidyssrd fvlrmrcegq qflvqfshvd eliywamyln 301 mgislsldle lremptyrsv prrrhprarr fkqhnknknk nksrqnsdrn dsrshslllr 361 rshtssvvtk vatgnerptn ksrsrslsll ppsvsdashd sngpndsgsl agessqtdfc 421 glftsklrnf fktdsssrkn snmdigqkmr skelnsvqee iddngsttnt ntsvlsstfs 481 ptahsvltaq tsihenfrsr snsnpidplr cdrsvlkinn fepvyegtgr stisnsaert 541 nreeklnrgn edvngdeddd ededdanyee ddedgyvedd dinrlvylde resryenadv 601 eygtifstks fsvtgclnhd fpkklslkcg nknqssndsk wapatqlvsr kryikdslrc 661 ikpltedhpw vgkiifkpal ppafetnnpp irvysgedst dlmhvknhyl kpyivgscgf 721 lktgsklfhf ydrtndltnl // LOCUS NP_001257688 130 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL143C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257688 VERSION NP_001257688.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270759.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35133. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..130 /product="uncharacterized protein" /calculated_mol_wt="15188" CDS 1..130 /locus_tag="YNL143C" /coded_by="NM_001270759.1:1..393" /note="hypothetical protein; expressed at both mRNA and protein levels" /db_xref="GeneID:855579" /db_xref="SGD:S000005087" ORIGIN 1 mreqlklftr eivdftflil sgfdyyqtll issnsskkrp kdssllsekk kkkkkkkkdv 61 lsylsylkdl pfvpflfwqp gysqreknpr qhslfimtit kpgmismadm nyvvsknrsl 121 nrpaerggnr // LOCUS NP_014257 499 aa linear PLN 30-JUN-2025 DEFINITION ammonium permease MEP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014257 VERSION NP_014257.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182980.1 REFERENCE 1 (residues 1 to 499) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 499) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 499) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 499) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10406. Method: conceptual translation. FEATURES Location/Qualifiers source 1..499 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..499 /product="ammonium permease MEP2" /calculated_mol_wt="53270" Region 32..444 /region_name="amt" /note="ammonium transporter; TIGR00836" /db_xref="CDD:273292" CDS 1..499 /gene="MEP2" /locus_tag="YNL142W" /coded_by="NM_001182980.1:1..1500" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11069679|PMID:24124599]" /experiment="EXISTENCE:direct assay:GO:0008519 ammonium channel activity [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9482721]" /experiment="EXISTENCE:mutant phenotype:GO:0008519 ammonium channel activity [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:1900430 positive regulation of filamentous growth of a population of unicellular organisms [PMID:32069286]" /note="Ammonium permease involved in regulation of pseudohyphal growth; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes human Rh factors; expression is under nitrogen catabolite repression regulation; activity is controlled by phospho-silencing; phosphorylation of Mep2 mediated by Npr1; dephosphorylation involves Psr1p and Psr2p; Twin-His motif ensures transport specificity" /db_xref="GeneID:855580" /db_xref="SGD:S000005086" ORIGIN 1 msynftgtpt gegtggnslt tdlntqfdla nmgwigvasa gvwimvpgig llysglsrkk 61 halsllwasm masavcifqw ffwgyslafs hntrgngfig tleffgfrnv lgapssvssl 121 pdilfavyqg mfaavtgalm lggacerarl fpmmvflflw mtivycpiac wvwnaegwlv 181 klgsldyagg lcvhltsghg glvyalilgk rndpvtrkgm pkykphsvts vvlgtvflwf 241 gwmffnggsa gnatirawys imstnlaaac ggltwmvidy frcgrkwttv glcsgiiagl 301 vgitpaagfv piwsavvigv vtgagcnlav dlksllridd gldcysihgv ggcigsvltg 361 ifaadyvnat agsyispidg gwinhhykqv gyqlagicaa lawtvtvtsi llltmnaipf 421 lklrlsadee elgtdaaqig eftyeestay ipepirskts aqmpppheni ddkivgntda 481 eknstpsdas stkntdhiv // LOCUS NP_014258 347 aa linear PLN 30-JUN-2025 DEFINITION adenine deaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014258 VERSION NP_014258.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182979.1 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10407. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..347 /product="adenine deaminase" /EC_number="3.5.4.2" /calculated_mol_wt="39504" Region 11..341 /region_name="A_deaminase" /note="Adenosine deaminase; pfam00962" /db_xref="CDD:425964" Site order(16,18,204,207,228,285..286) /site_type="active" /db_xref="CDD:238645" Site order(18,20,175,207,285..286) /site_type="other" /note="purine riboside binding site [chemical binding]" /db_xref="CDD:238645" CDS 1..347 /gene="AAH1" /locus_tag="YNL141W" /coded_by="NM_001182979.1:1..1044" /experiment="EXISTENCE:direct assay:GO:0000034 adenine deaminase activity [PMID:1577682]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006146 adenine catabolic process [PMID:1577682]" /experiment="EXISTENCE:direct assay:GO:0043101 purine-containing compound salvage [PMID:1577682]" /experiment="EXISTENCE:direct assay:GO:0043103 hypoxanthine salvage [PMID:1577682]" /experiment="EXISTENCE:mutant phenotype:GO:0000034 adenine deaminase activity [PMID:1577682]" /experiment="EXISTENCE:mutant phenotype:GO:0006146 adenine catabolic process [PMID:1577682]" /experiment="EXISTENCE:mutant phenotype:GO:0043101 purine-containing compound salvage [PMID:1577682]" /experiment="EXISTENCE:mutant phenotype:GO:0043103 hypoxanthine salvage [PMID:1577682]" /note="Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome" /db_xref="GeneID:855581" /db_xref="SGD:S000005085" ORIGIN 1 mvsveflqel pkcehhlhle gtlepdllfp lakrndiilp egfpksveel nekykkfrdl 61 qdfldyyyig tnvliseqdf fdlawayfkk vhkqglvhae vfydpqshts rgisietvtk 121 gfqracdkaf sefgitskli mcllrhiepe eclktieeat pfikdgtisa lgldsaekpf 181 pphlfvecyg kaaslnkdlk ltahageegp aqfvsdaldl lqvtridhgi nsqydeelld 241 rlsrdqtmlt icplsnvklq vvqsvselpl qkfldrdvpf slnsddpayf ggyildvytq 301 vskdfphwdh etwgriakna ikgswcddkr kngllsrvde vvtkysh // LOCUS NP_001257689 189 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL140C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257689 VERSION NP_001257689.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270760.1 REFERENCE 1 (residues 1 to 189) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 189) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 189) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 189) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35134. Method: conceptual translation. FEATURES Location/Qualifiers source 1..189 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..189 /product="uncharacterized protein" /calculated_mol_wt="21547" CDS 1..189 /locus_tag="YNL140C" /coded_by="NM_001270760.1:1..570" /note="hypothetical protein; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C" /db_xref="GeneID:855582" /db_xref="SGD:S000005084" ORIGIN 1 mleakmvmvv ptiedqamiv lhpkilsqsv vmhikgqnyq ldlvkvkhim ievghldpqv 61 rtgamvlikg itayvksirk tvhnvhnygf lkshfkrakt aakptltklh ltsatrlqkm 121 kksrikdsrr mkqletnfkr kiieiheiav lpiepmkikg tteierailr rfrkvprvgi 181 tsvgtrgny // LOCUS NP_014260 1597 aa linear PLN 30-JUN-2025 DEFINITION Tho2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014260 VERSION NP_014260.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182977.3 REFERENCE 1 (residues 1 to 1597) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1597) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1597) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1597) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1597) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1597) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1597) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1597) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10408. On Jul 30, 2012 this sequence version replaced NP_014260.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1597 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1597 /product="Tho2p" /calculated_mol_wt="183801" Region 30..656 /region_name="THOC2_N" /note="THO complex subunit 2 N-terminus; pfam16134" /db_xref="CDD:465032" Region 658..731 /region_name="Thoc2" /note="Transcription- and export-related complex subunit; pfam11732" /db_xref="CDD:463334" Region 938..1192 /region_name="Tho2" /note="Transcription factor/nuclear export subunit protein 2; pfam11262" /db_xref="CDD:463251" CDS 1..1597 /gene="THO2" /locus_tag="YNL139C" /gene_synonym="LDB5; RLR1; ZRG13" /coded_by="NM_001182977.3:1..4794" /experiment="EXISTENCE:direct assay:GO:0000445 THO complex part of transcription export complex [PMID:11979277]" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:24084588]" /experiment="EXISTENCE:direct assay:GO:0003676 nucleic acid binding [PMID:12093753]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:11139493]" /experiment="EXISTENCE:mutant phenotype:GO:0000446 nucleoplasmic THO complex [PMID:11060033]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:11060033]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:12093753|PMID:17960421]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:11979277]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:18614048]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:27251550]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:26663077]" /experiment="EXISTENCE:mutant phenotype:GO:0097185 cellular response to azide [PMID:27251550]" /experiment="EXISTENCE:mutant phenotype:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:26663077]" /note="Subunit of the THO complex; THO is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids" /db_xref="GeneID:855583" /db_xref="SGD:S000005083" ORIGIN 1 maeqtllskl nalsqkvipp aspsqasilt eevirnwper sktlcsdfta lesndekedw 61 lrtlfielfd finkndensp lklsdvasft nelvnherqv sqasivgkmf iavsstvpni 121 ndlttislck lipslheelf kfswisskll nkeqttllrh llkkskyelk kynllvensv 181 gygqlvalli layydpdnfs kvsaylkeiy himgkyslds irtldvilnv ssqfitegyk 241 ffiallrksd swpsshvann snysslnegg nmiaaniisf nlsqyneevd kenyerymdm 301 ccillkngfv nfysiwdnvk pemeflqeyi qnleteleee stkgvenpla maaalstene 361 tdednalvvn ddvnmkdkis eetnadiesk gkqktqqdil lfgkikller llihgcvipv 421 ihvlkqypkv lyvseslsry lgrvfeylln plytsmtssg eskdmatalm itridngila 481 hkprlihkyk thepfeslel nssyvfyyse wnsnltpfas vndlfenshi ylsiigpylg 541 riptllskis rigvadiqkn hgseslhvti dkwidyvrkf ifpatsllqn npiatsevye 601 lmkffpfekr yfiynemmtk lsqdilplkv sfnkaereak silkalsidt iakesrrfak 661 listnplasl vpavkqieny dkvselvvyt tkyfndfayd vlqfvlllrl tynrpavqfd 721 gvnqamwvqr lsifiaglak ncpnmdisni ityilktlhn gniiavsilk eliitvggir 781 dlnevnmkql lmlnsgsplk qyarhliydf rddnsvissr ltsfftdqsa iseiilllyt 841 lnlkantqns hykilstrcd emntllwsfi elikhclkgk afeenvlpfv elnnrfhlst 901 pwtfhiwrdy ldnqlnsnen fsideliega efsdvdltki skdlfttfwr lslydihfdk 961 slyderknal sgentghmsn rkkhliqnqi kdilvtgish qrafkktsef iseksnvwnk 1021 dcgedqikif lqncvvprvl fspsdalfss ffifmafrte nlmsilntci tsnilktllf 1081 cctsseagnl glfftdvlkk lekmrlngdf ndqasrklye whsviteqvi dllseknyms 1141 irngiefmkh vtsvfpvvka hiqlvyttle enlineered iklpssalig hlkarlkdal 1201 eldefctlte eeaeqkrire meleeiknye tacqneqkqv alrkqlelnk sqrlqndppk 1261 svasgsagln skdrytysrn epviptkpss sqwsyskvtr hvddinhyla tnhlqkaisl 1321 venddetrnl rklskqnmpi fdfrnstlei feryfrtliq npqnpdfaek idslkryikn 1381 isrepypdtt ssyseaaape ytkrssrysg naggkdgygs snyrgpsndr sapknikpis 1441 syahkrselp trpsksktyn drsralrptg pdrgdgfdqr dnrlreeykk nssqrsqlrf 1501 pekpfqegkd sskanpyqas sykrdspsen eekpnkrfkk detirnkfqt qdyrntrdsg 1561 aahranenqr yngnrksntq alpqgpkggn yvsryqr // LOCUS NP_878153 85 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit YSF3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_878153 VERSION NP_878153.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184519.1 REFERENCE 1 (residues 1 to 85) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 85) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 85) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 85) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10409. Method: conceptual translation. FEATURES Location/Qualifiers source 1..85 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..85 /product="U2 snRNP complex subunit YSF3" /calculated_mol_wt="9896" Region 3..73 /region_name="SF3b10" /note="Splicing factor 3B subunit 10 (SF3b10); pfam07189" /db_xref="CDD:462114" CDS 1..85 /gene="YSF3" /locus_tag="YNL138W-A" /gene_synonym="RCP10" /coded_by="NM_001184519.1:1..258" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:16314500|PMID:15565172]" /experiment="EXISTENCE:mutant phenotype:GO:0000245 spliceosomal complex assembly [PMID:16314500]" /note="Component of the SF3b subcomplex of the U2 snRNP; essential protein required for splicing and for assembly of SF3b" /db_xref="GeneID:1466511" /db_xref="SGD:S000028509" ORIGIN 1 maekqrqlkl qkiykqkyig lgdesttreq wqrnvrndtl ntlqghsasl eyvslsrgdl 61 sirdtrihll ksmspgykay lreer // LOCUS NP_014261 526 aa linear PLN 30-JUN-2025 DEFINITION adenylate cyclase-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_014261 VERSION NP_014261.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182976.1 REFERENCE 1 (residues 1 to 526) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 526) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 526) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 526) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10410. Method: conceptual translation. FEATURES Location/Qualifiers source 1..526 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..526 /product="adenylate cyclase-binding protein" /calculated_mol_wt="57391" Region 14..96 /region_name="CAP_N" /note="Adenylate cyclase associated (CAP) N terminal; pfam01213" /db_xref="CDD:460113" Region 368..524 /region_name="CAP_C" /note="Adenylate cyclase associated (CAP) C terminal; pfam08603" /db_xref="CDD:462532" CDS 1..526 /gene="SRV2" /locus_tag="YNL138W" /gene_synonym="CAP" /coded_by="NM_001182976.1:1..1581" /experiment="EXISTENCE:direct assay:GO:0003779 actin binding [PMID:19201756]" /experiment="EXISTENCE:direct assay:GO:0007015 actin filament organization [PMID:19201756]" /experiment="EXISTENCE:direct assay:GO:0008179 adenylate cyclase binding [PMID:2184942]" /experiment="EXISTENCE:direct assay:GO:0030042 actin filament depolymerization [PMID:26458246]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:8552082]" /experiment="EXISTENCE:direct assay:GO:0030836 positive regulation of actin filament depolymerization [PMID:26458246]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051014 actin filament severing [PMID:23135996]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:19201756]" /experiment="EXISTENCE:mutant phenotype:GO:0007265 Ras protein signal transduction [PMID:9774417]" /experiment="EXISTENCE:mutant phenotype:GO:0030833 regulation of actin filament polymerization [PMID:30639852]" /experiment="EXISTENCE:mutant phenotype:GO:0090141 positive regulation of mitochondrial fission [PMID:30639852]" /note="Cyclase-associated protein, CAP; accelerates nucleotide exchange and actin filament depolymerization; N-terminus binds adenylate cyclase, facilitating activation by RAS and directly catalyzes cofilin-mediated severing of actin filaments; C-terminus binds and recycles cofilin bound, ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis; processively tracks and promotes depolymerization of actin filament barbed and pointed ends; mCAP1 is the mouse homolog" /db_xref="GeneID:855584" /db_xref="SGD:S000005082" ORIGIN 1 mpdskytmqg ynlvkllkrl eeatarledv tiyqegyiqn kleasknnkp sdsgadantt 61 nepsaenape veqdpkcita fqsyigenid plvelsgkid tvvldalqll kggfqsqltf 121 lraavrsrkp dyssqtfads lrpineniik lgqlkesnrq skyfaylsal segaplfswv 181 avdtpvsmvt dfkdaaqfwt nrilkeyres dpnavewvkk flasfdnlka yikeyhttgv 241 swkkdgmdfa damaqstknt gatsspspas ataapapppp ppappasvfe isndtpatss 301 dankggigav faelnqgeni tkglkkvdks qqthknpelr qsstvsstgs ksgppprpkk 361 pstlktkrpp rkelvgnkwf ienyenetes lvidankdes ifigkcsqvl vqikgkvnai 421 slsetescsv vldssisgmd viksnkfgiq vnhslpqisi dksdggniyl skeslnteiy 481 tscstainvn lpigedddyv efpipeqmkh sfadgkfksa vfehag // LOCUS NP_014262 486 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS4m NAM9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014262 VERSION NP_014262.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182975.3 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10411. On Jul 30, 2012 this sequence version replaced NP_014262.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..486 /product="mitochondrial 37S ribosomal protein uS4m NAM9" /calculated_mol_wt="56225" Region <48..>172 /region_name="RpsD" /note="Ribosomal protein S4 or related protein [Translation, ribosomal structure and biogenesis]; COG0522" /db_xref="CDD:440288" Region 183..>347 /region_name="PRK12704" /note="phosphodiesterase; Provisional" /db_xref="CDD:237177" CDS 1..486 /gene="NAM9" /locus_tag="YNL137C" /gene_synonym="MNA6; uS4m" /coded_by="NM_001182975.3:1..1461" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal component of the small subunit" /db_xref="GeneID:855585" /db_xref="SGD:S000005081" ORIGIN 1 mprkanllks largrvrtsf nkynlfnlyk kggvdlksks lyqqkwtakq etrayhgehl 61 tekrwqtvfk pkldsvaqld aslrggeike tpfllqtfav lekrldfalf ramfassvrq 121 arqfilhgnv rvngvkikhp sytlkpgdmf svkpdkvlea lgakkpsfqe alkidktqiv 181 lwnkyvkeak tepkevwekk lenfekmsds npkklqfqef lrqynknles qqynalkgct 241 qegilrklln vekeigksnn eplsidelkq glpeiqdsql leslnnayqe ffksgeirre 301 iiskcqpdel islatemmnp nettkkelsd gaksalrsgk riiaesvklw tknitdhfkt 361 rmsdisdgsl tfdpkwaknl kyhdpiklse legdepkark linlpwqkny vygrqdpkkp 421 fftpwkprpf lspfailphh leisfktcha vylrdpvarp gqsevispfd vpvheraymy 481 ylrngk // LOCUS NP_014263 425 aa linear PLN 30-JUN-2025 DEFINITION Eaf7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014263 VERSION NP_014263.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182974.1 REFERENCE 1 (residues 1 to 425) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 425) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 425) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 425) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 425) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10412. Method: conceptual translation. FEATURES Location/Qualifiers source 1..425 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..425 /product="Eaf7p" /calculated_mol_wt="49260" Region 9..132 /region_name="Eaf7" /note="Chromatin modification-related protein EAF7; pfam07904" /db_xref="CDD:429728" CDS 1..425 /gene="EAF7" /locus_tag="YNL136W" /coded_by="NM_001182974.1:1..1278" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15353583]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15353583]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15353583]" /note="Subunit of the NuA4 histone acetyltransferase complex; NuA4 acetylates the N-terminal tails of histones H4 and H2A" /db_xref="GeneID:855586" /db_xref="SGD:S000005080" ORIGIN 1 mvvhwtivde irllrwasef kpagihkhfh mfcivermns pdkypvtllq ketmklgkvf 61 takdiwdkls qsynlekide mentysleat tessrngngn gddaeiheet llelnnrirv 121 rkqdftlpwe eygelilena rkspnsneey prvedmnekd stipkespst dlkndnnkqe 181 knatikvkel peyhteends pidvqkepik evqsdekelq rehmseeeqk mkstnktaap 241 vrksqrlkrs kevkfedeek eeieedntkd eeqkekkeei qepkithnee vdkeknenee 301 gddereksts yentngsese gvdegvdeel gyesereaeg kgkqiesegg nlkkktenkk 361 gddqqddtkk dskdknepla krtrhssstg ntsnetspkr krrkagsrkn sppatrvssr 421 lrnkk // LOCUS NP_014264 114 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase FPR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014264 VERSION NP_014264.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182973.1 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10413. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..114 /product="peptidylprolyl isomerase FPR1" /EC_number="5.2.1.8" /calculated_mol_wt="12027" Region 14..113 /region_name="FkpA" /note="FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]; COG0545" /db_xref="CDD:440311" CDS 1..114 /gene="FPR1" /locus_tag="YNL135C" /gene_synonym="FKB1; RBP1" /coded_by="NM_001182973.1:1..345" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:1996117]" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:36113412]" /experiment="EXISTENCE:direct assay:GO:0005527 macrolide binding [PMID:8325502]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:36113412|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:34534579]" /experiment="EXISTENCE:direct assay:GO:0070651 nonfunctional rRNA decay [PMID:36113412]" /experiment="EXISTENCE:direct assay:GO:1903332 regulation of protein folding [PMID:34534579]" /experiment="EXISTENCE:genetic interaction:GO:0006325 chromatin organization [PMID:10049913]" /experiment="EXISTENCE:genetic interaction:GO:1901710 regulation of homoserine biosynthetic process [PMID:15470257]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:32603360]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:32603360]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:9362068]" /note="Peptidyl-prolyl cis-trans isomerase (PPIase); binds to FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function; associates with promoters of ribosomal protein genes; acts as chaperone to prevent protein aggregation; N-terminally propionylated in vivo; mutation is functionally complemented by human FKBP1A" /db_xref="GeneID:855587" /db_xref="SGD:S000005079" ORIGIN 1 mseviegnvk idrispgdga tfpktgdlvt ihytgtleng qkfdssvdrg spfqcnigvg 61 qvikgwdvgi pklsvgekar ltipgpyayg prgfpglipp nstlvfdvel lkvn // LOCUS NP_014265 376 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL134C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014265 VERSION NP_014265.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182972.3 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10414. On Jul 30, 2012 this sequence version replaced NP_014265.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..376 /product="uncharacterized protein" /calculated_mol_wt="41033" Region 9..375 /region_name="enoyl_reductase_like" /note="cd08249" /db_xref="CDD:176211" Site order(46..47,152,184..187,208..209,211..212,227,249..250, 274..275,296,298,367..368) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:176211" CDS 1..376 /locus_tag="YNL134C" /coded_by="NM_001182972.3:1..1131" /experiment="EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:25656244]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:1901426 response to furfural [PMID:25656244]" /note="NADH-dependent aldehyde reductase; involved in detoxification of furfural; expression is up-regulated in the presence of furfural and 5-hydroxymethylfurfural, which are compounds generated during lignocellulosic biomass pre-treatment; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855588" /db_xref="SGD:S000005078" ORIGIN 1 msasipetmk avviengkav vkqdipipel eegfvliktv avagnptdwk hidfkigpqg 61 allgcdaagq ivklgpnvda arfaigdyiy gvihgasvrf psngafaeys aissetaykp 121 arefrlcgkd klpegpvksl egavslpvsl ttagmilths fgldmtwkps kaqrdqpilf 181 wggatavgqm liqlakklng fskiivvasr khekllkeyg adelfdyhda dvieqikkky 241 nnipylvdcv sntetiqqvy kcaaddldat vvqltvltek dikeedrrqn vsiegtllyl 301 iggndvpfgt ftlpadpeyk eaaikfikfi npkindgeih hipvkvykng lddipqlldd 361 ikhgrnsgek lvavlk // LOCUS NP_014266 173 aa linear PLN 30-JUN-2025 DEFINITION Fyv6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014266 VERSION NP_014266.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182971.3 REFERENCE 1 (residues 1 to 173) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 173) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 173) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 173) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10415. On Jul 30, 2012 this sequence version replaced NP_014266.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..173 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..173 /product="Fyv6p" /calculated_mol_wt="19894" CDS 1..173 /gene="FYV6" /locus_tag="YNL133C" /coded_by="NM_001182971.3:1..522" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:35705093]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12399380]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:12399380]" /note="Splicing factor, structural and functional homolog of human FAM192A; plays structural role in intermediate spliceosomal C* complex, which executes exon ligation; required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining" /db_xref="GeneID:855589" /db_xref="SGD:S000005077" ORIGIN 1 msstsdnnan sarekkplkf vsegvgnvea qrireqveqk kyeaeykrkt rkslrdqlrs 61 naiskqkqyn glvrdresft rlskedlefy qksknellkk ekelnnyldv kainfekkkk 121 allmendstt ntekyletgt slgsktqikg vktsspkpki kvsikklgrk len // LOCUS NP_014267 1056 aa linear PLN 30-JUN-2025 DEFINITION ribosome biosynthesis protein KRE33 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014267 VERSION NP_014267.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182970.1 REFERENCE 1 (residues 1 to 1056) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1056) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1056) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1056) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1056) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1056) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1056) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1056) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10416. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1056 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1056 /product="ribosome biosynthesis protein KRE33" /calculated_mol_wt="119217" Region 8..202 /region_name="TmcA_N" /note="tRNA(Met) cytidine acetyltransferase TmcA, N-terminal; pfam08351" /db_xref="CDD:462441" Region 108..906 /region_name="TmcA" /note="tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]; COG1444" /db_xref="CDD:441053" Region 536..766 /region_name="GNAT_acetyltr_2" /note="GNAT acetyltransferase 2; pfam13718" /db_xref="CDD:463966" Region 773..1007 /region_name="tRNA_bind_2" /note="Possible tRNA binding domain; pfam13725" /db_xref="CDD:463969" CDS 1..1056 /gene="KRE33" /locus_tag="YNL132W" /gene_synonym="RRA1" /coded_by="NM_001182970.1:1..3171" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:28542199]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:28542199]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:1990883 18S rRNA cytidine N-acetyltransferase activity [PMID:25086048]" /experiment="EXISTENCE:mutant phenotype:GO:0016556 mRNA modification [PMID:31243956]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:19806183|PMID:12150911]" /note="Acetyltransferase required for biogenesis of small ribosomal subunit; conserved 18S rRNA cytosine acetyltransferase that modifies tRNAs assisted by adaptor Tan1p; responsible for incorporation of N4-acetylcytidine into mRNAs; human homolog NAT10 implicated in several types of cancer and premature aging" /db_xref="GeneID:855591" /db_xref="SGD:S000005076" ORIGIN 1 makkaidsri pslirngvqt kqrsifvivg drarnqlpnl hylmmsadlk mnksvlwayk 61 kkllgftshr kkrenkikke ikrgtrevne mdpfesfisn qniryvyyke sekilgntyg 121 mcilqdfeal tpnllartie tvegggivvi llksmsslkq lytmtmdvha ryrteahgdv 181 varfnerfil slgsnpnclv vddelnvlpl sgaknvkplp pkeddelppk qlelqelkes 241 ledvqpagsl vslsktvnqa hailsfidai sektlnftva ltagrgrgks aalgisiaaa 301 vshgysnifv tspspenlkt lfefifkgfd algyqehidy diiqstnpdf nkaivrvdik 361 rdhrqtiqyi vpqdhqvlgq aelvvideaa aiplpivknl lgpylvfmas tingyegtgr 421 slslkliqql rnqnntsgre stqtavvsrd nkekdshlhs qsrqlreisl depiryapgd 481 piekwlnkll cldvtliknp rfatrgtphp sqcnlfvvnr dtlfsyhpvs enflekmmal 541 yvsshyknsp ndlqlmsdap ahklfvllpp idpkdggrip dplcviqial egeiskesvr 601 nslsrgqrag gdlipwlisq qfqdeefasl sgarivriat npeyasmgyg sraiellrdy 661 fegkftdmse dvrpkdysik rvsdkelakt nllkddvklr daktlpplll klseqpphyl 721 hylgvsyglt qslhkfwknn sfvpvylrqt andltgehtc vmlnvlegre snwlvefakd 781 frkrflslls ydfhkftavq alsviesskk aqdlsddekh dnkeltrthl ddifspfdlk 841 rldsysnnll dyhvigdmip mlallyfgdk mgdsvklssv qsaillaigl qrknidtiak 901 elnlpsnqti amfakimrkm sqyfrqllsq sieetlpnik ddaiaemdge eiknynaaea 961 ldqmeedlee agseavqamr ekqkelinsl nldkyaindn seewaesqks leiaakakgv 1021 vslktgkkrt tekaediyrq emkamkkprk skkaan // LOCUS NP_014268 152 aa linear PLN 30-JUN-2025 DEFINITION Tom22p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014268 VERSION NP_014268.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182969.1 REFERENCE 1 (residues 1 to 152) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 152) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 152) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 152) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10417. Method: conceptual translation. FEATURES Location/Qualifiers source 1..152 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..152 /product="Tom22p" /calculated_mol_wt="16659" Region 1..152 /region_name="TOM22" /note="Mitochondrial import receptor subunit TOM22 and similar proteins; cl11522" /db_xref="CDD:448294" Site order(100..101,104..105,107..109,111..112,115..116, 119..120,122) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:439375" Site order(104,107,111..112,115,119,122) /site_type="other" /note="putative phospholipid binding site [chemical binding]" /db_xref="CDD:439375" CDS 1..152 /gene="TOM22" /locus_tag="YNL131W" /gene_synonym="MAS17; MAS22; MOM22" /coded_by="NM_001182969.1:1..459" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:16689936]" /experiment="EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:10519552]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:9774667|PMID:10519552]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:12628251]" /note="Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as receptor for precursor proteins; implicated in mitochondrial accumulation of amyloid beta peptides via direct interaction with amyloid beta peptide residues 25-42 followed by transfer to Tom40p and transport through the TOM channel" /db_xref="GeneID:855592" /db_xref="SGD:S000005075" ORIGIN 1 mvelteikdd vvqldepqfs rnqaiveeka satnndvvdd eddsdsdfed efdenetlld 61 rivalkdivp pgkrqtisnf fgftssfvrn aftksgnlaw tltttalllg vplslsilae 121 qqliemektf dlqsdannil aqgekdaaat an // LOCUS NP_014269 393 aa linear PLN 30-JUN-2025 DEFINITION diacylglycerol cholinephosphotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014269 VERSION NP_014269.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182968.3 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10418. On Jul 30, 2012 this sequence version replaced NP_014269.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..393 /product="diacylglycerol cholinephosphotransferase" /EC_number="2.7.8.2" /calculated_mol_wt="44699" Region 1..391 /region_name="PRK10832" /note="CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; cl00453" /db_xref="CDD:469774" CDS 1..393 /gene="CPT1" /locus_tag="YNL130C" /coded_by="NM_001182968.3:1..1182" /experiment="EXISTENCE:direct assay:GO:0004142 diacylglycerol cholinephosphotransferase activity [PMID:3029130]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:3005242]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8543066]" /experiment="EXISTENCE:direct assay:GO:0006657 CDP-choline pathway [PMID:3029130]" /experiment="EXISTENCE:mutant phenotype:GO:0004142 diacylglycerol cholinephosphotransferase activity [PMID:3029130]" /experiment="EXISTENCE:mutant phenotype:GO:0006657 CDP-choline pathway [PMID:3029130]" /note="Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication" /db_xref="GeneID:855593" /db_xref="SGD:S000005074" ORIGIN 1 mgffipqssl gnlklykyqs ddrsflsnhv lrpfwrkfat ifplwmapnl vtllgfcfii 61 fnvlttlyyd pyfdqesprw tyfsyaiglf lyqtfdacdg mharrtgqqg plgelfdhci 121 dsinttlsmi pvcsmtgmgy tymtifsqfa ilcsfylstw eeyhthklyl aefcgpvegi 181 ivlcisfiav giygpqtiwh tkvaqfswqd fvfdvetvhl myafctgali fnivtahtnv 241 vryyesqstk satpsktaen iskavngllp ffayfssift lvliqpsfis lalilsigfs 301 vafvvgrmii ahltmqpfpm vnfpflipti qlvlyafmvy vldyqkgsiv salvwmglgl 361 tlaihgmfin diiydittfl diyalsikhp kei // LOCUS NP_878154 48 aa linear PLN 30-JUN-2025 DEFINITION Dgr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878154 VERSION NP_878154.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184574.1 REFERENCE 1 (residues 1 to 48) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 48) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 48) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 48) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 48) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 48) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 48) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 48) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10419. Method: conceptual translation. FEATURES Location/Qualifiers source 1..48 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..48 /product="Dgr1p" /calculated_mol_wt="5478" CDS 1..48 /gene="DGR1" /locus_tag="YNL130C-A" /coded_by="NM_001184574.1:1..147" /note="hypothetical protein; dgr1 null mutant is resistant to 2-deoxy-D-glucose" /db_xref="GeneID:1466512" /db_xref="SGD:S000028579" ORIGIN 1 mqvgfvsqtn crsfpacivf lfqmsqrqrs fnanlrvfks kckkiyig // LOCUS NP_014270 240 aa linear PLN 30-JUN-2025 DEFINITION ribosylnicotinamide kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014270 VERSION NP_014270.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182967.1 REFERENCE 1 (residues 1 to 240) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 240) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 240) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 240) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10420. Method: conceptual translation. FEATURES Location/Qualifiers source 1..240 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..240 /product="ribosylnicotinamide kinase" /EC_number="2.7.1.22" /EC_number="2.7.1.173" /calculated_mol_wt="27559" Region 8..198 /region_name="NRK1" /note="Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR...; cd02024" /db_xref="CDD:238982" Site order(13,18..21) /site_type="active" /db_xref="CDD:238982" CDS 1..240 /gene="NRK1" /locus_tag="YNL129W" /coded_by="NM_001182967.1:1..723" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0046495 nicotinamide riboside metabolic process [PMID:15137942]" /experiment="EXISTENCE:direct assay:GO:0050262 ribosylnicotinamide kinase activity [PMID:15137942]" /experiment="EXISTENCE:genetic interaction:GO:0009435 NAD+ biosynthetic process [PMID:17914902]" /experiment="EXISTENCE:genetic interaction:GO:0034355 NAD+ biosynthetic process via the salvage pathway [PMID:15137942]" /experiment="EXISTENCE:genetic interaction:GO:0046495 nicotinamide riboside metabolic process [PMID:15137942]" /note="Nicotinamide riboside kinase; catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis" /db_xref="GeneID:855594" /db_xref="SGD:S000005073" ORIGIN 1 mtskkvilva lsgcsssgkt tiakltaslf tkatlihedd fykhdnevpv dakyniqnwd 61 spealdfklf gkeldvikqt gkiatklihn nnvddpftkf hidrqvwdel kakydsindd 121 kyevvivdgf mifnntgisk kfdlkilvra pyevlkkrra srkgyqtlds fwvdppyyfd 181 efvyesyran haqlfvngdv eglldprksk nikefinddd tpiakplswv cqeilklckd // LOCUS NP_014271 434 aa linear PLN 30-JUN-2025 DEFINITION putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014271 VERSION NP_014271.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182966.4 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10421. On Jul 30, 2012 this sequence version replaced NP_014271.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..434 /product="putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase" /EC_number="3.1.3.67" /calculated_mol_wt="50021" Region 43..251 /region_name="PTP_PTEN-like" /note="protein tyrosine phosphatase-like domain of phosphatase and tensin homolog and similar proteins; cd14497" /db_xref="CDD:350347" CDS 1..434 /gene="TEP1" /locus_tag="YNL128W" /coded_by="NM_001182966.4:1..1305" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15913452]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:11070083]" /note="PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1" /db_xref="GeneID:855595" /db_xref="SGD:S000005072" ORIGIN 1 mreegselem ekgflkwkpv nlmkkilslp mkktkndigl rldisyilvn livcsypvnt 61 ypkllyrnsl ddlilfltvy hgkgnfrifn frgekedsdy kdndligiaa kfeskdfeiq 121 elrstlindg kipispidle trtlveeetn nvicerigwl dhfpppfell eeivdgieny 181 lsvsknrvav lhcrmgkgrs gmitvaylmk ylqcplgear lifmqarfky gmtngvtips 241 qlrylryhef fithekaaqe gisneavkfk fkfrlakmtf lrpsslitse saivttkiqh 301 ynddrnallt rkvvysdima hecggnmtfi fgrdyltlen dcrieftlgt skskaassii 361 swtscascwl niyletlmhi ikddsspdyf qverlkrdem lgttiswqel dgfgelsthg 421 lklfqalkle weii // LOCUS NP_014272 953 aa linear PLN 30-JUN-2025 DEFINITION Far11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014272 VERSION NP_014272.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182965.3 REFERENCE 1 (residues 1 to 953) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 953) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 953) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 953) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 953) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10422. On Jul 30, 2012 this sequence version replaced NP_014272.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..953 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..953 /product="Far11p" /calculated_mol_wt="109662" Region 219..485 /region_name="N1221" /note="N1221-like protein; pfam07923" /db_xref="CDD:429737" Region 585..928 /region_name="DUF3402" /note="Domain of unknown function (DUF3402); pfam11882" /db_xref="CDD:463384" CDS 1..953 /gene="FAR11" /locus_tag="YNL127W" /coded_by="NM_001182965.3:1..2862" /experiment="EXISTENCE:direct assay:GO:0000138 Golgi trans cisterna [PMID:22782902]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23625923]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:12588993]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:22782902]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:22782902]" /note="Protein involved in recovery from cell cycle arrest; acts in response to pheromone; also involved in regulation of intra-S DNA damage checkpoint and autophagy; is essential for dephosphorylation of Atg13p; interacts with Far3p, Far7p, Far8p, Far9p, Far10p and with the phosphatases Pph21p, Pph22p and Pph3p; has similarity to the N- and C-termini of N. crassa HAM-2; similar to human Fam40A and Fam40B" /db_xref="GeneID:855596" /db_xref="SGD:S000005071" ORIGIN 1 mnasgrshsk gpiirsvsle dlkrnssfkg nlkykdevts hkepqvgtls neellkdldn 61 mlrgklnmgr nsfhadkrnk sdgnisaltf karsglegdi rtidiqqdss dendnfkfsd 121 dgvnkdrnne kdnntdnave fqddaeeaee enedesfanv deldgfdlnk vsdgkhvpin 181 ekgevdynmp vdkefqksld qcaasleers sapyalqrav dwelkmfysl edelsewfcs 241 sdymhfgqtq tlfkqkitqp qlffddenya asvveclied ipnslasnll alsyismgcf 301 aftnskseht kiirrnnlml vphiqeivha fkkiaiscrd dnrnlkkqti llfhsstily 361 ficsiciegr genpeavnvv idafektdll efltkyienw rwnsrlamri rnmisllfkl 421 ivlqfgdssv ykqtkssiyn lhgltypskh peklsisplh yqafredits rfpdynmpss 481 glpkdvdkse slsqfleipr pksknplnma livpekhiat papsppsspq lmhlgegprp 541 rksfqtnmay pclypsdneg seddtledri dlnierkpdn divipfstee aarilsesle 601 iklstkqlwy erdlfmiter gwkqqlenep ydyaalnhda nsskeeksai cimqridkyy 661 ksclssfnsl vfvllqtmes sltnnfhrks evsdknllnm ltpqleivra kelslksaag 721 ilhallkwfk lshilkfehl avvihdsryi ntcasilsky sevypervfn kyvqtpnsfw 781 kecslsnesy resysvddsg evdteimpsf ayllrilrkv tgnktqrlke lplsigilfk 841 ryyrlfnldm yhpilkitre ltpfknkrwk sehmelisgv ylyekleltd nwvtgkdisg 901 elsdacgqei alrallqfyn fqhyeismed lgyghrnsss qdllnkesey lni // LOCUS NP_014273 846 aa linear PLN 30-JUN-2025 DEFINITION Spc98p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014273 VERSION NP_014273.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182964.1 REFERENCE 1 (residues 1 to 846) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 846) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 846) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 846) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 846) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 846) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 846) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 846) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10423. Method: conceptual translation. FEATURES Location/Qualifiers source 1..846 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..846 /product="Spc98p" /calculated_mol_wt="98096" Region 185..467 /region_name="GCP_N_terminal" /note="Gamma tubulin complex component N-terminal; pfam17681" /db_xref="CDD:465456" Region 476..823 /region_name="GCP_C_terminal" /note="Gamma tubulin complex component C-terminal; pfam04130" /db_xref="CDD:461187" CDS 1..846 /gene="SPC98" /locus_tag="YNL126W" /coded_by="NM_001182964.1:1..2541" /experiment="EXISTENCE:direct assay:GO:0005822 inner plaque of spindle pole body [PMID:9215630]" /experiment="EXISTENCE:direct assay:GO:0005824 outer plaque of spindle pole body [PMID:9215630]" /experiment="EXISTENCE:direct assay:GO:0007020 microtubule nucleation [PMID:24842996|PMID:11950928]" /experiment="EXISTENCE:direct assay:GO:0008275 gamma-tubulin small complex [PMID:9384578|PMID:9130700|PMID:25599398]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:9153752]" /experiment="EXISTENCE:mutant phenotype:GO:0043015 gamma-tubulin binding [PMID:8670895]" /experiment="EXISTENCE:physical interaction:GO:0008275 gamma-tubulin small complex [PMID:9130700]" /experiment="EXISTENCE:physical interaction:GO:0043015 gamma-tubulin binding [PMID:8670895|PMID:9130700]" /note="Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque" /db_xref="GeneID:855597" /db_xref="SGD:S000005070" ORIGIN 1 meleptlfgi iealapqlls qshlqtfvsd vvnllrsstk satqlgplid fyklqsldsp 61 ettimwhkie kfldalfgiq ntddmvkyls vfqsllpsny rakivqkssg lnmenlanhe 121 hllspvraps iyteasfenm drfserrsmv sspnryvpss tyssvtlrql snpyyvntip 181 eedilkyvsy tllattsalf pfdheqiqip skipnfesgl lhlifeagll yqslgykvek 241 frmlnispmk kaliieisee lqnytafvnn lvssgtvvsl kslyreiyen iirlriycrf 301 tehleelsgd tflielnifk shgdltirki atnlfnsmis lyyeylmnwl tkgllratyg 361 effiaentdt ngtdddfiyh ipiefnqerv pafipkelay kifmigksyi flekyckevq 421 wtnefskkyh vlyqsnsyrg istnffeiin dqyseivnht nqilnqkfhy rdvvfalkni 481 llmgksdfmd aliekandil atpsdslpny kltrvlqeav qlsslrhlmn sprnssving 541 ldarvldlgh gsvgwdvftl dyilypplsl vlnvnrpfgr keylrifnfl wrfkknnyfy 601 qkemlksndi irsfkkirgy nplirdiink lsrisilrtq fqqfnskmes yylnciieen 661 fkemtrklqr tenksqnqfd lirlnngtie lngiltpkae vltksssskp qkhaiektln 721 idelesvhnt fltnilshkl fatntseisv gdysgqpypt slvlllnsvy efvkvycnln 781 digyeifikm nlndheasng llgkfntnlk eivsqyknfk drlyifradl kndgdeelfl 841 lskslr // LOCUS NP_014274 673 aa linear PLN 30-JUN-2025 DEFINITION Esbp6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014274 VERSION NP_014274.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182963.1 REFERENCE 1 (residues 1 to 673) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 673) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 673) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 673) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 673) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 673) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 673) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 673) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10424. Method: conceptual translation. FEATURES Location/Qualifiers source 1..673 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..673 /product="Esbp6p" /calculated_mol_wt="73671" Region 212..606 /region_name="MFS_MCT_SLC16" /note="Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; cd17352" /db_xref="CDD:340910" Site order(223..224,227..228,231,269,320..321,323..325,328,347, 350..351,354,435,438..439,442..444,447,474,478,528..529, 533,537,553,556..557,560..561,564) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340910" CDS 1..673 /gene="ESBP6" /locus_tag="YNL125C" /gene_synonym="MCH3" /coded_by="NM_001182963.1:1..2022" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11536335]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Protein with similarity to monocarboxylate permeases; appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane" /db_xref="GeneID:855598" /db_xref="SGD:S000005069" ORIGIN 1 msthsndyfs assgmvsets sevssinssq pvsfskasia apvpcsdlhs tksndasrkl 61 sisrtltnrl ndikkavddd nlqteensad vnkilesrfd vadairlqhn esvqsklnip 121 vthtttagas lsapsssafs assiqndtte hkasmdsklm rnrlypastk hsgkdleaqg 181 itefepdept vkkvftnkst gqlelppdgg ygwvvtfcvf ltmfstwgcn asfgvdlayy 241 lnhdtypgas kydyaliagl tvflgqllsp lvmalmriig lrttmlfgda vmlaayllas 301 fttklwqlyv tqgfmvgcsi slifvpattv lpgwflkkra vamgvsllgt gaggvvygla 361 tnkmlsdfgn trwclriigi scsisvlvai allkernptp aiglkspram feqlkamfsl 421 kvitkpfvvl ialwfmfalf aynmmvftls syaiskglss hdastltail ngsqsigrpl 481 mglagdkfgr anvtivlttl ltiymfafwi pahtfvqlif fsilvgscvg vanvmntvli 541 admvkpeefl pawafvnycg apfllvcevi aqaltvekdk snpylhaqif cgccfiaali 601 lisilreysi rmklterqam tneklkewka seydtdsade dwgklkerkt kydlllgpgi 661 kkyflrmvyp mkv // LOCUS NP_014275 492 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding snoRNP assembly protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_014275 VERSION NP_014275.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182962.3 REFERENCE 1 (residues 1 to 492) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 492) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 492) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 492) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10425. On Jul 30, 2012 this sequence version replaced NP_014275.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..492 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..492 /product="RNA-binding snoRNP assembly protein" /calculated_mol_wt="54819" Region 137..226 /region_name="Gar1" /note="Gar1/Naf1 RNA binding region; pfam04410" /db_xref="CDD:461296" Region 297..>417 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..492 /gene="NAF1" /locus_tag="YNL124W" /coded_by="NM_001182962.3:1..1479" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12515383]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:12242285|PMID:12515383]" /experiment="EXISTENCE:mutant phenotype:GO:0000493 box H/ACA snoRNP assembly [PMID:12242285|PMID:12228251|PMID:12515383]" /experiment="EXISTENCE:physical interaction:GO:0000493 box H/ACA snoRNP assembly [PMID:12515383|PMID:12228251]" /experiment="EXISTENCE:physical interaction:GO:0003723 RNA binding [PMID:12515383]" /note="RNA-binding protein required for the assembly of box H/ACA snoRNPs; thus required for pre-rRNA processing; forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p" /db_xref="GeneID:855599" /db_xref="SGD:S000005068" ORIGIN 1 msddlfskal enpdqdlnve lpkddvdlgl lgdggnerkt depvadaers tglgsgsses 61 esdsgsdsds dsgssgsedd sadqdveged eggdaiened ededpspsgp ilskneilee 121 tvpelpedye isektiitpi gvlksafenn iiihatmsge krvlkegsif cledrtligm 181 ltevfgplqn pfyriklpds kknlfdelkv rlgekafivt pdahwidtfe lkrnkgtdas 241 ngydeelpee eqefsddeke alfkkmkkqq rqrkkrdnrk landsdnvkv krarqpkans 301 lpklvpplgm ssnapmqhgy ksrnarenik ressatsnrn gsspvpitqh hqqqfsanny 361 pfpqqpngmp yppyspfpqp tnfqyppppf gqatpaqfsn tvpygslppa ynnmspptqq 421 sfmpmtqsqp plpygvppmn qmqnpmyiqp ppqappqgng nfqqvmelhq illqqqqqqh 481 qyqhqhqqdp rt // LOCUS NP_014276 997 aa linear PLN 30-JUN-2025 DEFINITION Nma111p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014276 VERSION NP_014276.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182961.1 REFERENCE 1 (residues 1 to 997) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 997) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 997) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 997) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 997) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 997) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 997) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 997) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10426. Method: conceptual translation. FEATURES Location/Qualifiers source 1..997 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..997 /product="Nma111p" /calculated_mol_wt="110751" Region <42..91 /region_name="DUF5923" /note="Family of unknown function (DUF5923); pfam19343" /db_xref="CDD:466049" Region 102..390 /region_name="DegQ" /note="Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; COG0265" /db_xref="CDD:440035" Region 299..387 /region_name="cpPDZ1_ScNma111-like" /note="circularly permuted first PDZ domain (PDZ1) of Saccharomyces cerevisiae pro-apoptotic serine protease Nma111p and related domains; cd06786" /db_xref="CDD:467625" Site order(301..308,325,328,358..359,362) /site_type="other" /note="peptide binding site [polypeptide binding]" /db_xref="CDD:467625" Region 392..469 /region_name="PDZ_1" /note="PDZ-like domain; pfam12812" /db_xref="CDD:372324" Region 572..865 /region_name="DegQ" /note="Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; COG0265" /db_xref="CDD:440035" Region 772..862 /region_name="cpPDZ3_ScNma111-like" /note="circularly permuted third PDZ domain (PDZ3) of Saccharomyces cerevisiae pro-apoptotic serine protease Nma111p and related domains; cd10827" /db_xref="CDD:467627" Site order(774..781,796,799,830..831,834) /site_type="other" /note="peptide binding site [polypeptide binding]" /db_xref="CDD:467627" Region 871..950 /region_name="PDZ2-4_Nma111p-like" /note="second and fourth PDZ domains (PDZ2 and 4) of Saccharomyces cerevisiae pro-apoptotic serine protease Nma111p and related domains; cd06719" /db_xref="CDD:467617" CDS 1..997 /gene="NMA111" /locus_tag="YNL123W" /gene_synonym="YNM3" /coded_by="NM_001182961.1:1..2994" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14657274|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008236 serine-type peptidase activity [PMID:18946088]" /experiment="EXISTENCE:mutant phenotype:GO:0004252 serine-type endopeptidase activity [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:16470384]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:16608876|PMID:14657274|PMID:16470384]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:18946088]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:29861160]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:18946088]" /experiment="EXISTENCE:mutant phenotype:GO:0120174 stress-induced homeostatically regulated protein degradation pathway [PMID:29861160]" /experiment="EXISTENCE:physical interaction:GO:0006629 lipid metabolic process [PMID:16470384]" /note="Serine protease and general molecular chaperone; cleaves Roq1p, which modifies the substrate specificity of the Ubr1p Ub-ligase, promoting the stress-induced homeostatically-regulated protein degradation (SHRED) of misfolded and native ER-membrane and cytosolic proteins; chaperone activity involved in the heat stress response; promotes apoptosis through proteolysis of Bir1p; role in lipid homeostasis; mammalian Omi/HtrA2 serine protease family member" /db_xref="GeneID:855600" /db_xref="SGD:S000005067" ORIGIN 1 mtislsnikk rdhskisdgt sgesslvkrk qlesatgdqe eeytdheiii eplhfannnn 61 tvltdsenyl rwqntisnvv ksvvsihfsq vapfdcdsal vseatgfvvd aklgiiltnr 121 hvvgpgpfvg yvvfdnheec dvipiyrdpv hdfgflkfdp knikyskika ltlkpslakv 181 gseirvvgnd ageklsilag fisridrnap eygeltyndf nteyiqaaas asggssgspv 241 vnidgyaval qaggsteast dfflpldril raliciqtnk pitrgtiqvq wllkpydecr 301 rlgltseres earakfpeni gllvaetvlr egpgydkike gdtlisinge tissfmqvdk 361 iqdenvgkei qlviqrggve ctvtctvgdl haitphryve vcgatfhels yqmarfyalp 421 vrgvflssas gsfnfdsker vgwivdsidn ketpdldtfi eimktipdrk rvtvryhhlt 481 dqhsplvtsi yidrhwcnef rvytrndttg iwdyknvadp lpadalkprs akiipipvnn 541 ekvaklsssl ctvatmaavp ldslsadilk tsgliidaek gyvlvsrrvv phdcldtfvt 601 iadslvvpat veflhpthnf aivkydpelv kaplitpkls ttrmkrgdkl qfigftqndr 661 ivtsettvtd issvsipsnl ipryratnle aisidcnvst rcnsgiltdn dgtvrglwlp 721 flgerlenke kvylmgldim dcrevidilk nggkprvsiv dagfgsisvl qarirgvpee 781 wimrmehesn nrlqfitvsr vsytedkihl etgdvilsvn gklvtemndl ngvvssadgi 841 lpsamldfkv vrdgnivdlk iktvevqetd rfvifagsil qkphhavlqa mvdvpkgvyc 901 tfrgesspal qygisatnfi thvneietpd ldtflkvvkt ipdnsyckmr lmtfdnvpfa 961 islktnyhyf ptaelkrdni thkwiekeft gnsqsek // LOCUS NP_014277 115 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL35m MRP35 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014277 VERSION NP_014277.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182960.1 REFERENCE 1 (residues 1 to 115) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 115) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 115) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 115) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10427. Method: conceptual translation. FEATURES Location/Qualifiers source 1..115 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..115 /product="mitochondrial 54S ribosomal protein bL35m MRP35" /calculated_mol_wt="13112" Region 55..112 /region_name="Ribosomal_L35p" /note="Ribosomal protein L35; pfam01632" /db_xref="CDD:460273" CDS 1..115 /gene="MRP35" /locus_tag="YNL122C" /gene_synonym="bL35m" /coded_by="NM_001182960.1:1..348" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:24675956]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:24675956]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:17054397|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:24675956]" /note="Mitochondrial ribosomal protein of the large subunit; homologous to bacterial L35 and human MRPL35 ribosomal proteins" /db_xref="GeneID:855601" /db_xref="SGD:S000005066" ORIGIN 1 mkislhnkrq rgdqnqnmsv fnvlkpllkg snsfkvklng flfnnvstit irtlmkthkg 61 takrwrrtgn tfkrgiagrk hgnigwshrs lkaltgrkia hpayskhlkr llpyh // LOCUS NP_014278 617 aa linear PLN 30-JUN-2025 DEFINITION protein channel TOM70 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014278 VERSION NP_014278.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182959.3 REFERENCE 1 (residues 1 to 617) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 617) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 617) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 617) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 617) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 617) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 617) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 617) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10428. On Jul 30, 2012 this sequence version replaced NP_014278.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..617 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..617 /product="protein channel TOM70" /calculated_mol_wt="69992" Region 1..614 /region_name="3a0801s09" /note="mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); TIGR00990" /db_xref="CDD:273380" Region 99..127 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(100,103..104,107..108,110,133,136..137,140..141, 143..144,167,170..171,174..175,178) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 131..161 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 166..189 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 330..358 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 363..391 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(364,367..368,371..372,374,398,401..402,405..406, 408..409,432,435..436,439..440,443) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 396..426 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 431..459 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 465..493 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 498..537 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 542..567 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..617 /gene="TOM70" /locus_tag="YNL121C" /gene_synonym="MAS70; MOM72; OMP1" /coded_by="NM_001182959.3:1..1854" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:11502169]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407|PMID:16689936]" /experiment="EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:37366411]" /experiment="EXISTENCE:direct assay:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:2177474]" /experiment="EXISTENCE:genetic interaction:GO:0006626 protein targeting to mitochondrion [PMID:18007655]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:2177474]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:8132642]" /experiment="EXISTENCE:mutant phenotype:GO:0030943 mitochondrion targeting sequence binding [PMID:11054285]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:2177474]" /note="Component of the TOM (translocase of outer membrane) complex; involved in recognition and initial import steps for all mitochondrially-directed proteins, acting as a receptor for incoming precursors; role in the distribution of tail-anchored proteins between mitochondria and peroxisomes; moonlighting role as a transcriptional regulator of mitochondrial proteins; age-dependent reduction in Tom70p results in mitochondrial dysfunction, a hallmark of aging; localizes to mitochondria-ER contact sites" /db_xref="GeneID:855602" /db_xref="SGD:S000005065" ORIGIN 1 mksfitrnkt ailatvaatg taigayyyyn qlqqqqqrgk kntinkdekk dtkdsqkete 61 gakkstapsn ppiypvssng epdfsnkanf taeekdkyal alkdkgnqff rnkkyddaik 121 yynwalelke dpvfysnlsa cyvsvgdlkk vvemstkale lkpdyskvll rrasaneglg 181 kfadamfdls vlslngdfnd asiepmlern lnkqamsklk ekfgdidtat atptelstqp 241 akerkdkqen lpsvtsmasf fgifkpeltf anydesnead kelmnglsnl ykrspesydk 301 adesftkaar lfeeqldknn edeklkekla islehtgifk flkndplgah edikkaielf 361 prvnsyiyma limadrndst eyynyfdkal kldsnnssvy yhrgqmnfil qnydqagkdf 421 dkakeldpen ifpyiqlacl ayrenkfddc etlfseakrk fpeapevpnf faeiltdknd 481 fdkalkqydl aielenkldg iyvgiaplvg katlltrnpt venfieatnl lekaskldpr 541 seqakiglaq mklqqedide aitlfeesad lartmeeklq aitfaeaakv qqrirsdpvl 601 akkiqetlak lreqglm // LOCUS NP_014280 493 aa linear PLN 30-JUN-2025 DEFINITION Ncs2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014280 VERSION NP_014280.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182957.3 REFERENCE 1 (residues 1 to 493) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 493) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 493) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 493) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 493) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10429. On Jul 30, 2012 this sequence version replaced NP_014280.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..493 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..493 /product="Ncs2p" /calculated_mol_wt="56342" Region 323..446 /region_name="CTU2" /note="Cytoplasmic tRNA 2-thiolation protein 2; pfam10288" /db_xref="CDD:463044" CDS 1..493 /gene="NCS2" /locus_tag="YNL119W" /gene_synonym="TUC2" /coded_by="NM_001182957.3:1..1482" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:14551258]" /experiment="EXISTENCE:mutant phenotype:GO:0002143 tRNA wobble position uridine thiolation [PMID:19145231|PMID:18755837|PMID:19151091|PMID:18664566|P MID:17018299]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:14551258]" /experiment="EXISTENCE:mutant phenotype:GO:0032447 protein urmylation [PMID:14551258]" /note="Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs; required for the thiolation of uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae" /db_xref="GeneID:855603" /db_xref="SGD:S000005063" ORIGIN 1 mecqrcpasa rnpatvesrk ekfcdecfik fvstkqrkqm mkdeyfrnlf kviypfekeg 61 svskillpls hsdsgslvml divhdllleq tkqhnnrtgf tvdvltvfte envsvikerm 121 eslinekmsq lnkisnifnv hfidvneffn nasevstfii dnenfeifsk sksvddsnil 181 tlkeilgkyc lnnssrsdli siiktqlikh fayengynai mwghsmtkls eviislvvkg 241 kgsqiatfld sesfdtlnnk pckyknlypm kdllsveies flqirnlaqf linveetnvk 301 pncliarksl pslgqqklvk nmtineitnk yfqdiqndys niistvlrta dkltqpkssm 361 akpsqcqicq skiytnpsnw lnritvtspy pvetteekyl fkqwqdsklg qshthyvell 421 neikqgasns ldvedgdvkl cygclillnt sikdknlvwp kvdtmditan atnknkelsq 481 ildqfeinsd gee // LOCUS NP_014281 970 aa linear PLN 30-JUN-2025 DEFINITION decapping enzyme complex catalytic subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_014281 VERSION NP_014281.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182956.1 REFERENCE 1 (residues 1 to 970) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 970) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 970) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 970) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 970) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 970) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 970) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 970) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10430. Method: conceptual translation. FEATURES Location/Qualifiers source 1..970 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..970 /product="decapping enzyme complex catalytic subunit" /EC_number="3.6.1.62" /calculated_mol_wt="108536" Region 17..99 /region_name="DCP2" /note="Dcp2, box A domain; pfam05026" /db_xref="CDD:428265" Region 103..242 /region_name="NUDIX_Dcp2p_Nudt20" /note="mRNA decapping enzyme 2; cd03672" /db_xref="CDD:467540" CDS 1..970 /gene="DCP2" /locus_tag="YNL118C" /gene_synonym="PSU1" /coded_by="NM_001182956.1:1..2913" /experiment="EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:10508173|PMID:11139489]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23509072|PMID:12730603]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11139489]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:23706738|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0016787 hydrolase activity [PMID:12486012]" /experiment="EXISTENCE:direct assay:GO:0098562 cytoplasmic side of membrane [PMID:27146487]" /experiment="EXISTENCE:direct assay:GO:0098745 RNA decapping complex [PMID:12554866]" /experiment="EXISTENCE:genetic interaction:GO:0034063 stress granule assembly [PMID:20513766]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:10508173]" /experiment="EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15225544]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:20513766]" /experiment="EXISTENCE:mutant phenotype:GO:0060261 positive regulation of transcription initiation by RNA polymerase II [PMID:23706738]" /experiment="EXISTENCE:physical interaction:GO:0098745 RNA decapping complex [PMID:10508173]" /note="Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex; removes 5' cap structure from mRNAs prior to their degradation; also enters nucleus and positively regulates transcription initiation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress; human homolog DCP2 complements yeast dcp2 thermosensitive mutant" /db_xref="GeneID:855605" /db_xref="SGD:S000005062" ORIGIN 1 mslplrhale nvtsvdrile dllvrfiinc pnedlssver elfhfeeasw fytdfiklmn 61 ptlpslkiks faqliiklcp lvwkwdirvd ealqqfskyk ksipvrgaai fnenlskill 121 vqgtesdsws fprgkiskde ndidccirev keeigfdltd yiddnqfier niqgknykif 181 lisgvsevfn fkpqvrneid kiewfdfkki sktmyksnik yylinsmmrp lsmwlrhqrq 241 iknedqlksy aeeqlklllg itkeeqidpg rellnmlhta vqansnnnav sngqvpssqe 301 lqhlkeqsge hnqqkdqqss fssqqqpsif pslsepfann knvipptmpm anvfmsnpql 361 fatmngqpfa pfpfmlpltn nsnsanpipt pvppnfnapp npmafgvpnm hnlsgpavsq 421 pfslppaplp rdsgyssssp gqlldilnsk kpdsnvqssk kpklkilqrg tdlnsikqnn 481 ndetahsnsq alldllkkpt ssqkihaskp dtsflpndsv sgiqdaeyed fesssdeeve 541 tardernsln vdigvnvmps ekdsrrsqke kprndasktn lnasaesnsv ewgpgkssps 601 tqskqnssvg mqnkyrqeih igdsdayevf esssdeedgk kleeleqtqd nsklisqdil 661 kennfqdgev phrdmptesn ksinetvgls sttntvkkvp kvkilkrget faslandkka 721 fdsssnvsss kdllqmlrnp isstvssnqq spksqhlsgd eeimmmlkrn svskpqnsee 781 nastssinda nasellgmlk qkekditapk qpynvdsysq knsakgllni lkkndstgyp 841 rteggpssem stsmkrndat nnqeldknst ellnylkpkp lndgyenisn kdsshellni 901 lhgnknssaf nnnvyatdgy slasdnnens snkllnmlqn rssainepnf dvrsngtsgs 961 nellsilhrk // LOCUS NP_014282 554 aa linear PLN 30-JUN-2025 DEFINITION malate synthase MLS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014282 VERSION NP_014282.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182955.1 REFERENCE 1 (residues 1 to 554) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 554) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 554) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10431. Method: conceptual translation. FEATURES Location/Qualifiers source 1..554 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..554 /product="malate synthase MLS1" /EC_number="2.3.3.9" /calculated_mol_wt="62660" Region 31..542 /region_name="malate_synt_A" /note="Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; cd00727" /db_xref="CDD:238369" Site order(177,261,287,289,457) /site_type="active" /db_xref="CDD:238369" CDS 1..554 /gene="MLS1" /locus_tag="YNL117W" /coded_by="NM_001182955.1:1..1665" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:27678487|PMID:2211514]" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:11846793]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:11846793]" /experiment="EXISTENCE:mutant phenotype:GO:0004474 malate synthase activity [PMID:23642236|PMID:8878673]" /experiment="EXISTENCE:mutant phenotype:GO:0006097 glyoxylate cycle [PMID:8878673|PMID:23642236]" /note="Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic; can accept butyryl-CoA as acyl-CoA donor in addition to traditional substrate acetyl-CoA" /db_xref="GeneID:855606" /db_xref="SGD:S000005061" ORIGIN 1 mvkvsldnvk llvdvdkepf fkpssttvgd iltkdalefi vllhrtfnnk rkqllenrqv 61 vqkkldsgsy hldflpetan irndptwqgp ilapglinrs teitgpplrn mlinalnapv 121 ntymtdfeds asptwnnmvy gqvnlydair nqidfdtprk syklngnvan lptiivrprg 181 whmvekhlyv ddepisasif dfglyfyhna keliklgkgp yfylpkmehh leaklwndvf 241 cvaqdyigip rgtiratvli etlpaafqme eiiyqlrqhs sglncgrwdy ifstikrlrn 301 dpnhilpnrn qvtmtspfmd ayvkrlintc hrrgvhamgg maaqipikdd paanekamtk 361 vrndkirelt nghdgswvah palapicnev finmgtpnqi yfipenvvta anlletkipn 421 geittegivq nldiglqyme awlrgsgcvp innlmedaat aevsrcqlyq wvkhgvtlkd 481 tgekvtpelt ekilkeqver lskasplgdk nkfalaakyf lpeirgekfs eflttllyde 541 ivstkatptd lskl // LOCUS NP_014283 522 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-conjugating protein DMA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014283 VERSION NP_014283.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182954.3 REFERENCE 1 (residues 1 to 522) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 522) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 522) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 522) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10432. On Jul 30, 2012 this sequence version replaced NP_014283.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..522 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..522 /product="ubiquitin-conjugating protein DMA2" /EC_number="2.3.2.27" /calculated_mol_wt="57453" Region 259..402 /region_name="FHA_DMA-like" /note="forkhead associated (FHA) domain found in Saccharomyces cerevisiae defective in mitotic arrest protein 1 (DMA1), 2 (DMA2) and similar proteins; cd22692" /db_xref="CDD:438744" Site order(298..299,326..327,329,347,349..350) /site_type="other" /note="putative phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438744" Region 431..477 /region_name="RING-H2_Dmap-like" /note="RING finger, H2 subclass, found in defective in mitotic arrest proteins (Dmap) and similar proteins; cd16458" /db_xref="CDD:319372" CDS 1..522 /gene="DMA2" /locus_tag="YNL116W" /gene_synonym="CHF2" /coded_by="NM_001182954.3:1..1569" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:18202552]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051865 protein autoubiquitination [PMID:18202552]" /experiment="EXISTENCE:genetic interaction:GO:0000132 establishment of mitotic spindle orientation [PMID:15146058|PMID:22570619]" /experiment="EXISTENCE:genetic interaction:GO:0000921 septin ring assembly [PMID:22570619|PMID:15146058]" /experiment="EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:21562220]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:22570619|PMID:15146058]" /experiment="EXISTENCE:genetic interaction:GO:0032186 cellular bud neck septin ring organization [PMID:22570619]" /experiment="EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:22570619]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:18202552]" /experiment="EXISTENCE:mutant phenotype:GO:0005934 cellular bud tip [PMID:23442799]" /experiment="EXISTENCE:mutant phenotype:GO:0032177 cellular bud neck split septin rings [PMID:23442799]" /experiment="EXISTENCE:mutant phenotype:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:27449057]" /experiment="EXISTENCE:physical interaction:GO:0090337 regulation of formin-nucleated actin cable assembly [PMID:27449057]" /note="Ubiquitin-protein ligase (E3); controls septin dynamics and spindle position checkpoint (SPOC) with ligase Dma1p by regulating recruitment of Elm1p to bud neck; regulates levels of eIF2 subunit Gcd11p, as well as abundance, localization, and ubiquitination of Cdk inhibitory kinase Swe1p; ortholog of human RNF8, similar to human Chfr; contains FHA and RING finger domains; DMA2 has a paralog, DMA1, that arose from the whole genome duplication" /db_xref="GeneID:855607" /db_xref="SGD:S000005060" ORIGIN 1 mytpipantp aptaptssmt snsssasnan ttsssginpr nrasgtpsne rarpasgiss 61 flntfgirqn sqtasssaap dqrlfgttps nshmsvames idtapqqqep rlhhpiqmpl 121 saqfhvhrny qlpisislta ptttdhqqss ahnfegnnvg nvqeslnqrq pngtnnttts 181 iismapaatt rnivggadgs tivnnsqemy knlrhliyaa nqpngteilh ldlpatsaee 241 snnmfnvdev tlkqrkdkhg lfsirltpfi dsssttnqgl ffepiirkag pgsqlvigry 301 tervrdaisk ipeqyhpvvf kskvvsrthg cfkvdsqgnw yikdvksssg tflnhqrlsp 361 asslskdtpl rdgdilqlgm dfrggteeiy rcvrmrieln rswklkansf nkealqrlqn 421 lqklttgiee edcsiclcki kpcqaifisp cahswhfrcv rrlvmlsypq fvcpncrssc 481 dleasfessd eedesdvese gdqlvdqlsv lmetskdvds hp // LOCUS NP_014284 644 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL115C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014284 VERSION NP_014284.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182953.1 REFERENCE 1 (residues 1 to 644) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 644) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 644) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 644) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10433. Method: conceptual translation. FEATURES Location/Qualifiers source 1..644 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..644 /product="uncharacterized protein" /calculated_mol_wt="73908" Region 26..328 /region_name="DUF2417" /note="Region of unknown function (DUF2417); pfam10329" /db_xref="CDD:431216" Region 348..551 /region_name="Abhydrolase_1" /note="alpha/beta hydrolase fold; pfam00561" /db_xref="CDD:395444" CDS 1..644 /locus_tag="YNL115C" /coded_by="NM_001182953.1:1..1935" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene" /db_xref="GeneID:855608" /db_xref="SGD:S000005059" ORIGIN 1 mkangldndp artgmertdi dsehpeaqpl lnnnhrtlga gsangpavne grdiesdgfi 61 kdslfqirkg yrifihnskw ilnililint iwlvttlisd fffninilfg fsnryasfnd 121 ltlifisiia nsfnlwfnkl glysaldysl nvtlcvltlf nlaltyliky trqrigfvgt 181 ftylwtsfsf figaildwyl lfynnsinep leerriddan istfnenhtn stenrdrsqy 241 gsgsptpthr sqlvqnkhtl tewvsigfrn tikfliliff alftlntllt tldtyrlthk 301 lpitvqspsy eafhyvdaak tyqlhitcyg dvfdqenntd lsenkkqpii lfehggydtg 361 ylsatwieel yhldkiqryc lydrpgygls dsppapisia mvaeslryal ikdakikgpf 421 ttvgydlggl ftrvftaknv divdsmmlve swheelllkn yiqrllppgr gdgddgddgn 481 gndgdgrnhd ktwlpseier hnefrlwwkg iwsslgwrlq tswllahhgs keriygrdmk 541 yqgrflrskf lesvtssils yrdvtnnaes lqnvktsivs skemvkksal wgdwqrdltk 601 ishktqewki veggheiyky glgkqqtqev llrligelgk lted // LOCUS NP_014286 142 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase core subunit RPC19 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014286 VERSION NP_014286.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182951.1 REFERENCE 1 (residues 1 to 142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 142) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10434. Method: conceptual translation. FEATURES Location/Qualifiers source 1..142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..142 /product="DNA-directed RNA polymerase core subunit RPC19" /calculated_mol_wt="16020" Region 52..135 /region_name="RNAP_I_III_AC19" /note="AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; cd07029" /db_xref="CDD:132907" Site order(65,70..72,74,79,93,121..122,127..129,131..133) /site_type="other" /note="AC19 - AC40 heterodimer interface [polypeptide binding]" /db_xref="CDD:132907" Site order(70,95..96) /site_type="other" /note="AC19 - A135(C128) interaction site [polypeptide binding]" /db_xref="CDD:132907" Site order(77,88,90..92,94..96) /site_type="other" /note="AC19 - A190(C160) interaction site [polypeptide binding]" /db_xref="CDD:132907" Site 87 /site_type="other" /note="AC19 - RPB8 interaction site [polypeptide binding]" /db_xref="CDD:132907" CDS 1..142 /gene="RPC19" /locus_tag="YNL113W" /coded_by="NM_001182951.1:1..429" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /note="RNA polymerase subunit AC19; common to RNA polymerases I and III" /db_xref="GeneID:855609" /db_xref="SGD:S000005057" ORIGIN 1 mtedieqkkt atevtpqepk hiqeeeeqdv dmtgdeeqee epdrekikll tqatsedgts 61 asfqiveedh tlgnalryvi mknpdvefcg ysiphpsenl lniriqtyge ttavdalqkg 121 lkdlmdlcdv veskftekik sm // LOCUS NP_014287 546 aa linear PLN 30-JUN-2025 DEFINITION DEAD-box ATP-dependent RNA helicase DBP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014287 VERSION NP_014287.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182950.3 REFERENCE 1 (residues 1 to 546) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 546) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 546) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 546) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10435. On Jul 30, 2012 this sequence version replaced NP_014287.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..546 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..546 /product="DEAD-box ATP-dependent RNA helicase DBP2" /EC_number="3.6.4.13" /calculated_mol_wt="60868" Region 4..492 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Site order(133,135..137,140,158..165) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350724" CDS 1..546 /gene="DBP2" /locus_tag="YNL112W" /coded_by="NM_001182950.3:1..1641" /experiment="EXISTENCE:direct assay:GO:0002151 G-quadruplex RNA binding [PMID:30855040]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:23721653]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:30902808]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22679025]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006369 termination of RNA polymerase II transcription [PMID:30902808]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:22679025]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:30902808]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:30855040]" /experiment="EXISTENCE:genetic interaction:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:22679025]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11585918]" /experiment="EXISTENCE:mutant phenotype:GO:0008186 ATP-dependent activity, acting on RNA [PMID:22679025]" /experiment="EXISTENCE:mutant phenotype:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:22679025]" /experiment="EXISTENCE:physical interaction:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:7883168]" /note="ATP-dependent RNA helicase of the DEAD-box protein family; strong preference for dsRNA; remodels RNP structure for efficient transcription termination; required for assembly of Yra1p, Nab2p and Mex67p onto mRNA and formation of nuclear mRNP; involved in mRNA decay and rRNA processing; may suppress transcription from cryptic initiation sites; promotes Mex67p-mediated nuclear export of mRNA by facilitating annealing with antisense RNAs to create dsRNAs; binds G-quadruplex (G4) nucleic acids" /db_xref="GeneID:855611" /db_xref="SGD:S000005056" ORIGIN 1 mtyggrdqqy nktnyksrgg dfrggrnsdr nsyndrpqgg nyrggfggrs nynqpqelik 61 pnwdeelpkl ptfeknfyve hesvrdrsds eiaqfrkene mtisghdipk pittfdeagf 121 pdyvlnevka egfdkptgiq cqgwpmalsg rdmvgiaatg sgktlsyclp givhinaqpl 181 lapgdgpivl vlaptrelav qiqtecskfg hssrirntcv yggvpksqqi rdlsrgseiv 241 iatpgrlidm leigktnlkr vtylvldead rmldmgfepq irkivdqirp drqtlmwsat 301 wpkevkqlaa dylndpiqvq vgslelsash nitqivevvs dfekrdrlnk yletasqdne 361 yktlifastk rmcdditkyl redgwpalai hgdkdqrerd wvlqefrngr spimvatdva 421 argidvkgin yvinydmpgn iedyvhrigr tgragatgta isffteqnkg lgaklisimr 481 eanqnippel lkydrrsygg ghprygggrg grggygrrgg ygggrggygg nrqrdggwgn 541 rgrsny // LOCUS NP_014288 120 aa linear PLN 30-JUN-2025 DEFINITION Cyb5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014288 VERSION NP_014288.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182949.3 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10436. On Jul 30, 2012 this sequence version replaced NP_014288.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..120 /product="Cyb5p" /calculated_mol_wt="13166" Region 6..78 /region_name="Cyt-b5" /note="Cytochrome b5-like Heme/Steroid binding domain; pfam00173" /db_xref="CDD:459698" CDS 1..120 /gene="CYB5" /locus_tag="YNL111C" /coded_by="NM_001182949.3:1..363" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12514182]" /experiment="EXISTENCE:direct assay:GO:0009055 electron transfer activity [PMID:10622712]" /experiment="EXISTENCE:direct assay:GO:0016126 sterol biosynthetic process [PMID:10622712]" /note="Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation" /db_xref="GeneID:855612" /db_xref="SGD:S000005055" ORIGIN 1 mpkvysyqev aehngpenfw iiiddkvydv sqfkdehpgg deiimdlggq datesfvdig 61 hsdealrllk glyigdvdkt servsvekvs tsenqskgsg tlvvilailm lgvayyllne // LOCUS NP_014289 220 aa linear PLN 30-JUN-2025 DEFINITION rRNA-binding ribosome biosynthesis protein NOP15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014289 VERSION NP_014289.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182948.1 REFERENCE 1 (residues 1 to 220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 220) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10437. Method: conceptual translation. FEATURES Location/Qualifiers source 1..220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..220 /product="rRNA-binding ribosome biosynthesis protein NOP15" /calculated_mol_wt="25316" Region 92..168 /region_name="RRM_Nop15p" /note="RNA recognition motif in yeast ribosome biogenesis protein 15 (Nop15p) and similar proteins; cd12552" /db_xref="CDD:409968" CDS 1..220 /gene="NOP15" /locus_tag="YNL110C" /coded_by="NM_001182948.1:1..663" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10953080]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11583614]" /experiment="EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350|PMID:23212245]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:27643814]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:27643814]" /note="Constituent of 66S pre-ribosomal particles; involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm" /db_xref="GeneID:855613" /db_xref="SGD:S000005054" ORIGIN 1 mvkstsktst ketvtkqpte ekpiqekeel aletsssssd eedekdedei eglaasddeq 61 sgthkikrln pkkqanekks kdkktleeys giiyvsrlph gfhekelsky faqfgdlkev 121 rlarnkktgn srhygflefv nkedamiaqe smnnyllmgh llqvrvlpkg akieklykyk 181 krvlvekgit kpvkqlkdnm kqkheerikk laksgiefkw // LOCUS NP_014291 270 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL108C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014291 VERSION NP_014291.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182946.1 REFERENCE 1 (residues 1 to 270) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 270) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 270) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 270) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10438. Method: conceptual translation. FEATURES Location/Qualifiers source 1..270 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..270 /product="uncharacterized protein" /calculated_mol_wt="30617" Region 5..203 /region_name="HP_PGM_like" /note="Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; cd07067" /db_xref="CDD:132718" Site order(10..11,68,168..169) /site_type="active" /note="catalytic core [active]" /db_xref="CDD:132718" CDS 1..270 /locus_tag="YNL108C" /gene_synonym="HUF" /coded_by="NM_001182946.1:1..813" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016311 dephosphorylation [PMID:23569204]" /experiment="EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:23569204]" /note="Protein phosphatase; similar to prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus; YNL108C has a paralog, TFC7, that arose from the whole genome duplication" /db_xref="GeneID:855615" /db_xref="SGD:S000005052" ORIGIN 1 maieniyiar hgyrsnwlpk gpypppptgi dndvplsehg veqahelany iskldvkpem 61 ifsspfyrcl etskptveal kiplyvdrgv gewykpdrpi ipepathevm skffpsmisp 121 dwepsiipsn kgeteedife rchkfwpvfi drverkfpnv ktimivthaa tksalgmnll 181 kfssakepid nkgtfirngs caidkfelvk genesipfee rewkltmngn tsfltngeem 241 nwtfmnafea gsdadikarr aaesgklkme // LOCUS NP_014292 226 aa linear PLN 30-JUN-2025 DEFINITION YEATS domain-containing protein YAF9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014292 VERSION NP_014292.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182945.3 REFERENCE 1 (residues 1 to 226) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 226) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 226) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10439. On Jul 30, 2012 this sequence version replaced NP_014292.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..226 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..226 /product="YEATS domain-containing protein YAF9" /calculated_mol_wt="25850" Region 1..226 /region_name="TFG3" /note="Transcription initiation factor IIF, auxiliary subunit [Transcription]; COG5033" /db_xref="CDD:227366" CDS 1..226 /gene="YAF9" /locus_tag="YNL107W" /coded_by="NM_001182945.3:1..681" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:14690608|PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:14645854]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:15485911]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15302830]" /note="Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes; may function to antagonize silencing near telomeres; interacts directly with Swc4p; has homology to human leukemogenic protein AF9; contains a YEATS domain" /db_xref="GeneID:855616" /db_xref="SGD:S000005051" ORIGIN 1 maptiskrik tlsvsrpiiy gntakkmgsv kppnapaeht hlwtifvrgp qnedisyfik 61 kvvfklhdty pnpvrsieap pfeltetgwg efdinikvyf veeanekvln fyhrlrlhpy 121 anpvpnsdng neqnttdhns kdaevssvyf deivfnepne effkilmsrp gnllpsnktd 181 dcvyskqleq eeidrieigi ekvdkeidel kqklenlvkq eaings // LOCUS NP_014293 1183 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014293 VERSION NP_014293.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182944.1 REFERENCE 1 (residues 1 to 1183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1183) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10440. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1183 /product="phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52" /EC_number="3.1.3.36" /calculated_mol_wt="133201" Region 1..628 /region_name="COG5329" /note="Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]" /db_xref="CDD:227637" Region 564..1052 /region_name="COG5411" /note="Phosphatidylinositol 5-phosphate phosphatase [Signal transduction mechanisms]" /db_xref="CDD:227698" Region <978..1166 /region_name="Aim21" /note="Altered inheritance of mitochondria protein 21; pfam11489" /db_xref="CDD:371558" CDS 1..1183 /gene="INP52" /locus_tag="YNL106C" /gene_synonym="SJL2" /coded_by="NM_001182944.1:1..3552" /experiment="EXISTENCE:direct assay:GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11094088]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:15798181|PMID:11094088]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10224048]" /experiment="EXISTENCE:mutant phenotype:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:9438131]" /experiment="EXISTENCE:mutant phenotype:GO:0046856 phosphatidylinositol dephosphorylation [PMID:9438131]" /experiment="EXISTENCE:physical interaction:GO:0030479 actin cortical patch [PMID:15798181]" /note="Polyphosphatidylinositol phosphatase; dephosphorylates a number of phosphatidylinositol phosphates (PtdInsPs, PIPs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain; INP52 has a paralog, INP53, that arose from the whole genome duplication" /db_xref="GeneID:855618" /db_xref="SGD:S000005050" ORIGIN 1 mkillskqqt rkiaivseth glvfrpinsk nsrrstcave lvpkaelngn gfrrlsnhei 61 ygfiglieie glmfiatitg kskvaqpipn ktvnkiyavd ffclnnskwd fmdidssgyp 121 ivtndgdfai ssppsisths srsslrssss rslnaqeqap khpchelrkl lsngsfyyst 181 dfdltctlqk rgftehslsf ddfdrefmwn sflmdeiity rdrldvtake lldqrgfltt 241 virgfaetif syinrlkvgl tiisrqswkr agtrfnargi dddghvanfv etemimyssq 301 ycyaftqirg slpifweqdt slispkiqit rsveatqptf dehfirlfkk ygpvhiinll 361 stksseiqls rrykeqlkns ekmkigrdvf ltsfdfhret sqdgfaaasr iipkirntil 421 dagyfsydvk egrliseqdg vfrtncldcl drtnliqqti slavfklfle dfrlvkpssf 481 iddnefvqkv nalwadngdq isqiytgtna lkssysrkgk msfsgalsda tksvsrmyin 541 nfvdkgkqqn idtllgklph qqvvelydpi ceyvnerlle seekftthsn inlfvgtfnv 601 ngnsrradls kwlfpigdkf kpdvvvlglq evieltagsi lnadytkssf wetmvtdcln 661 qyeekylllr veqmssllil ffarsdrayn ikevggstkk tgfggitgnk gavairfdyg 721 atsfcfvnth lsagasnide rrndynniyr nitfprskti phhdslfwlg dlnyritltn 781 devrrelraq kdgyidrllq ydqltqeine gvvfqgfkep tlqfrptyky dygtdnydts 841 ekartpswtd riiykgenlh playsdaplk isdhkpvyaa yranvkfvde keklnlvekl 901 yaeyknthpe alttgpdels harmekqkes ipldatvqsa giklidlddt sscvspllsg 961 pspqpsvvgp gglsnvspdk sklnvlpppp ptsrhnkeps skllsptkei sivsvsprkg 1021 esnlpalerh stpkplppvp alslskpvsl qkssselqha ketidngkiv prpcppirrk 1081 sstapdeist stknsgvstt edpepakast kpekppvvkk phylsvaank lntsqehsik 1141 vspsnsksee elpckkkskp kvpaknpele klsvhplkpc dpn // LOCUS NP_014295 619 aa linear PLN 30-JUN-2025 DEFINITION 2-isopropylmalate synthase LEU4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014295 VERSION NP_014295.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182942.1 REFERENCE 1 (residues 1 to 619) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 619) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 619) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 619) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10441. Method: conceptual translation. FEATURES Location/Qualifiers source 1..619 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..619 /product="2-isopropylmalate synthase LEU4" /EC_number="2.3.3.13" /calculated_mol_wt="68278" Region 35..596 /region_name="leuA_yeast" /note="2-isopropylmalate synthase, yeast type; TIGR00970" /db_xref="CDD:273371" CDS 1..619 /gene="LEU4" /locus_tag="YNL104C" /coded_by="NM_001182942.1:1..1860" /experiment="EXISTENCE:direct assay:GO:0003852 2-isopropylmalate synthase activity [PMID:3275644|PMID:25841022]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:3275644|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:3275644|PMID:16823961|PMID:14562095|PMID:24769239|PM ID:11914276|PMID:14576278|PMID:25841022]" /experiment="EXISTENCE:genetic interaction:GO:0009098 L-leucine biosynthetic process [PMID:10790691]" /experiment="EXISTENCE:mutant phenotype:GO:0009098 L-leucine biosynthetic process [PMID:25841022]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:25841022]" /note="Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication" /db_xref="GeneID:855619" /db_xref="SGD:S000005048" ORIGIN 1 mvkesiiala ehaasrasrv ippvklaykn mlkdpsskyk pfnapklsnr kwpdnritra 61 prwlstdlrd gnqslpdpms veqkkeyfhk lvnigfkeie vsfpsasqtd fdftryaven 121 apddvsiqcl vqsrehlikr tvealtgakk atihtylats dmfreivfnm sreeaiskav 181 eatklvrklt kddpsqqatr wsyefspecf sdtpgefave iceavkkawe pteenpiifn 241 lpatvevasp nvyadqieyf athiterekv cisthchndr gcgvaatelg mlagadrveg 301 clfgngertg nvdlvtvamn mytqgvspnl dfsdltsvld vvercnkipv sqrapyggdl 361 vvcafsgshq daikkgfnlq nkkraqgetq wripylpldp kdigrdyeav irvnsqsgkg 421 gaawvilrsl gldlprnmqi efssavqdha dslgrelksd eisklfkeay nyndeqyqai 481 slvnynvekf gterrvftgq vkvgdqivdi egtgngpiss lvdalsnlln vrfavanyte 541 hslgsgsstq aasyihlsyr rnadnekayk wgvgvsedvg dssvraifat inniihsgdv 601 sipslaeveg knaaasgsa // LOCUS NP_014296 672 aa linear PLN 30-JUN-2025 DEFINITION Met4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014296 VERSION NP_014296.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182941.3 REFERENCE 1 (residues 1 to 672) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 672) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 672) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 672) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 672) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10442. On Jul 30, 2012 this sequence version replaced NP_014296.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..672 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..672 /product="Met4p" /calculated_mol_wt="74171" CDS 1..672 /gene="MET4" /locus_tag="YNL103W" /coded_by="NM_001182941.3:1..2019" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:9799240]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9799240]" /experiment="EXISTENCE:direct assay:GO:0046685 response to arsenic-containing substance [PMID:15689486]" /experiment="EXISTENCE:direct assay:GO:0046686 response to cadmium ion [PMID:15689486]" /experiment="EXISTENCE:direct assay:GO:0089713 Cbf1-Met4-Met28 complex [PMID:8665859|PMID:9171357]" /experiment="EXISTENCE:mutant phenotype:GO:0000096 sulfur amino acid metabolic process [PMID:1549123]" /experiment="EXISTENCE:mutant phenotype:GO:0010438 cellular response to sulfur starvation [PMID:39138175]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:39138175]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22696683|PMID:39138175]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:9799240]" /note="Leucine-zipper transcriptional activator; regulates the sulfur amino acid pathway; requires different combinations of auxiliary factors Cbf1p, Met28p, Met31p and Met32p; specific involvement in sulfur starvation-induced autophagy with Gcn4p; feedforward loop exists in the regulation of genes controlled by Met4p and Met32p; ubiquitinated by SCF-Met30p, leading to either degradation or maintenance in an inactive state; regulates degradation of its DNA-binding cofactors by SCF-Met30p targeting" /db_xref="GeneID:855620" /db_xref="SGD:S000005047" ORIGIN 1 mkqeqshegd systefinlf gkdtathpss nngannngmg stnsldqfva tassssslvt 61 ssenrrplig dvtnrgntnl ydhavtpeil leqlayvdnf ipsldnefsn vdwnvntthn 121 nannngadtf ssinanpfdl deqlaielsa faddsfifpd edkpsnnnnn snngnddhsn 181 hdvlhedpst nnrqrnphfl tqrrntflts qydqsksrfs sknkrngnng etnnfgdnmq 241 nnhpfepnfm gspsqfpada tnmtsidhgg ftnvditste nnttgdngvd alsnllhrtt 301 htpnrsspls nvtsaqnsss qqrkhseskv dsnsdnnssn kapnitvpdy siiptsvlvt 361 llprvnvpng aynslisagf dndqidaiaa imayhhqkki rennsnnnkn intndsqeap 421 ilkninells vlippspaet aapttlstsp sfnehgvvae asflssilel gikhpksnni 481 hnqrqpsrnd hkisresdgn ngndnvhhnn avikssttrg deiakirsep tlnasssdhk 541 enslkrshsg dlknkkvpvd rkysdnedde yddadlhgfe kkqlikkelg dddedlliqs 601 kkshqkkklk ekelessihe lteiaaslqk rihtletenk llknlvlssg etegikkaes 661 lkkqifekvq ke // LOCUS NP_014297 1468 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed DNA polymerase alpha catalytic subunit POL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014297 VERSION NP_014297.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182940.3 REFERENCE 1 (residues 1 to 1468) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1468) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1468) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1468) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10443. On Jul 30, 2012 this sequence version replaced NP_014297.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1468 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1468 /product="DNA-directed DNA polymerase alpha catalytic subunit POL1" /EC_number="2.7.7.7" /calculated_mol_wt="166679" Region 29..1227 /region_name="pol2" /note="DNA polymerase (pol2); TIGR00592" /db_xref="CDD:273159" Region 1269..1463 /region_name="zf-DNA_Pol" /note="DNA Polymerase alpha zinc finger; pfam08996" /db_xref="CDD:462651" CDS 1..1468 /gene="POL1" /locus_tag="YNL102W" /gene_synonym="CDC17; CRT5; HPR3" /coded_by="NM_001182940.3:1..4407" /experiment="EXISTENCE:direct assay:GO:0000510 H3-H4 histone complex chaperone activity [PMID:38713623]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:1704371|PMID:3907855|PMID:3888995]" /experiment="EXISTENCE:direct assay:GO:0005657 replication fork [PMID:15773893]" /experiment="EXISTENCE:direct assay:GO:0005658 alpha DNA polymerase:primase complex [PMID:3888995|PMID:22593576]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006278 RNA-templated DNA biosynthetic process [PMID:17429354]" /experiment="EXISTENCE:mutant phenotype:GO:0000510 H3-H4 histone complex chaperone activity [PMID:38713623]" /experiment="EXISTENCE:mutant phenotype:GO:0000731 DNA synthesis involved in DNA repair [PMID:2651896]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:2651896]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:2651896]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:10025407]" /note="Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis; H3-H4 histone chaperone, downstream of Pol32p, involved in the transfer of parental histones to the lagging strand during DNA replication" /db_xref="GeneID:855621" /db_xref="SGD:S000005046" ORIGIN 1 msskseklek lrklqaarng tsiddyegde sdgdriydei dekeyrarkr qellhddfvv 61 dddgvgyvdr gveedwrevd nsssdedtgn laskdskrkk nikrekdhqi tdmlrtqhsk 121 stllahakks qkksipidnf ddilgefesg evekpnillp sklrenlnss ptsefkssik 181 rvngndessh dagiskkvki dpdsstdkyl eiessplklq srklryandv qdllddvens 241 pvvatkrqnv lqdtllanpp saqsladeed dedsdediil krrtmrsvtt trrvnidsrs 301 npstspfvta pgtpigikgl tpskslqsnt dvatlavnvk kedvvdpetd tfqmfwldyc 361 evnntlilfg kvklkddncv samvqinglc relfflpreg ktptdiheei ipllmdkygl 421 dnirakpqkm kysfelpdip sesdylkvll pyqtpkssrd tipsdlssdt fyhvfggnsn 481 ifesfviqnr imgpcwldik gadfnsirna shcavevsvd kpqnitpttt ktmpnlrcls 541 lsiqtlmnpk enkqeivsit lsayrnisld spipenikpd dlctlvrppq stsfplglaa 601 lakqklpgrv rlfnnekaml scfcamlkve dpdviighrl qnvyldvlah rmhdlniptf 661 ssigrrlrrt wpekfgrgns nmnhffisdi csgrlicdia nemgqsltpk cqswdlsemy 721 qvtcekehkp ldidyqnpqy qndvnsmtma lqenitncmi saevsyriql ltltkqltnl 781 agnawaqtlg gtragrneyi llhefsrngf ivpdkegnrs raqkqrqnee nadapvnskk 841 akyqgglvfe pekglhknyv lvmdfnslyp siiqefnicf ttvdrnkedi delpsvppse 901 vdqgvlprll anlvdrrrev kkvmktetdp hkrvqcdirq qalkltansm ygclgyvnsr 961 fyakplamlv tnkgreilmn trqlaesmnl lvvygdtdsv midtgcdnya daikiglgfk 1021 rlvneryrll eididnvfkk lllhakkkya altvnldkng ngttvlevkg ldmkrrefcp 1081 lsrdvsihvl ntilsdkdpe ealqevydyl edirikvetn niridkykin mklskdpkay 1141 pggknmpavq valrmrkagr vvkagsvitf vitkqdeidn aadtpalsva erahalnevm 1201 iksnnlipdp qyylekqifa pverllerid sfnvvrlsea lgldskkyfr reggnnnged 1261 innlqplett itdverfkdt vtlelscpsc dkrfpfggiv ssnyyrvsyn glqckhceql 1321 ftplqltsqi ehsirahisl yyagwlqcdd stcgivtrqv svfgkrclnd gctgvmryky 1381 sdkqlynqll yfdslfdcek nkkqelkpiy lpddldypke qltessikal teqnrelmet 1441 grsvvqkyln dcgrryvdmt sifdfmln // LOCUS NP_014298 713 aa linear PLN 30-JUN-2025 DEFINITION Avt4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014298 VERSION NP_014298.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182939.1 REFERENCE 1 (residues 1 to 713) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 713) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 713) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 713) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 713) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10444. Method: conceptual translation. FEATURES Location/Qualifiers source 1..713 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..713 /product="Avt4p" /calculated_mol_wt="79895" Region 295..711 /region_name="Aa_trans" /note="Transmembrane amino acid transporter protein; pfam01490" /db_xref="CDD:279788" CDS 1..713 /gene="AVT4" /locus_tag="YNL101W" /coded_by="NM_001182939.1:1..2142" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11274162]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:genetic interaction:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:genetic interaction:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:genetic interaction:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:genetic interaction:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0005302 L-tyrosine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015186 L-glutamine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0015188 L-isoleucine transmembrane transporter activity [PMID:11274162]" /experiment="EXISTENCE:mutant phenotype:GO:0032974 amino acid transmembrane export from vacuole [PMID:11274162]" /note="Vacuolar transporter; exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs)" /db_xref="GeneID:855622" /db_xref="SGD:S000005045" ORIGIN 1 mvtnngdgeh lgirrngnlr hpsnnmkipr raqstvlnsn pfysrkysms tltprdicrs 61 vdsrvfvdms spnfqtledp hrdeiinsvr lnylnsskrs svshgneaip rvnptknssa 121 stiaaanvds dddetnlssa ggdithdiyk lvkaedpkrl rrprsmenvt pkiehhtkls 181 sasglnvpgg frrefivnkk rqehqlndsa ssdftshesd sinqsspssn qdidkvpflt 241 rnfleflyvf ghfagesfed dfipdssnmm irgedersal lsrpdhmkvl psakgttstk 301 kvflillksf igtgvlflpn afhngglffs vsmlaffgiy sywcyyilvq aksscgvssf 361 gdiglklygp wmriiilfsl vitqvgfsga ymiftaknlq afldnvfhvg vlplsylmvf 421 qtiifiplsf irnisklslp sllanffima glviviifta krlffdlmgt pamgvvygln 481 adrwtlfigt aifafegigl iipvqdsmrn pekfplvlal viltatilfi siatlgylay 541 gsnvqtvill nlpqsnifvn liqlfysiai mlstplqlfp aikiienkff pkftkiyvkh 601 ddlttrvelr pnsgklnwki kwlknfirsi iviivvsiay fgsdnldkfv svigslacip 661 lvyiypsmlh lrgnslpetk gefwrfkpml dtiliffgia smlytsyqsi fgv // LOCUS NP_014299 234 aa linear PLN 30-JUN-2025 DEFINITION Mic27p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014299 VERSION NP_014299.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182938.1 REFERENCE 1 (residues 1 to 234) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 234) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 234) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 234) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 234) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10445. Method: conceptual translation. FEATURES Location/Qualifiers source 1..234 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..234 /product="Mic27p" /calculated_mol_wt="26829" CDS 1..234 /gene="MIC27" /locus_tag="YNL100W" /gene_synonym="AIM37; MCS27" /coded_by="NM_001182938.1:1..705" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0044284 mitochondrial crista junction [PMID:22009199]" /experiment="EXISTENCE:direct assay:GO:0061617 MICOS complex [PMID:21944719|PMID:21987634|PMID:22009199]" /experiment="EXISTENCE:mutant phenotype:GO:0032461 positive regulation of protein oligomerization [PMID:29733859]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:22009199|PMID:21944719|PMID:21987634]" /experiment="EXISTENCE:mutant phenotype:GO:0043933 protein-containing complex organization [PMID:26968360]" /note="Component of the MICOS complex; MICOS (formerly MINOS or MitOS), a mitochondrial inner membrane complex that extends into the intermembrane space with a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic12p whose assembly and stability requires cardiolipin; positive regulator of Mic10p oligomerization along with cardiolipin; orthologous to human APOO and APOOL" /db_xref="GeneID:855623" /db_xref="SGD:S000005044" ORIGIN 1 mvnfyddvde skshgefpli pvvlqnssel svrtiptgne iiesvhltkw lrkyrnalas 61 qldryekgwq skianfrlqv qhvinysrkn ifnvdsenkh tvvpgslial gaffagsiav 121 nrsnwgakrl ifghkssile klctslpsri llpwvlaaat fkywapqtsq nlvnatendl 181 lpadfvksyh ntwkriyeeg yvakkcdlkr qidqtlqkni ryareqlyek leqa // LOCUS NP_014300 238 aa linear PLN 30-JUN-2025 DEFINITION putative tyrosine protein phosphatase OCA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014300 VERSION NP_014300.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182937.3 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10446. On Jul 30, 2012 this sequence version replaced NP_014300.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..238 /product="putative tyrosine protein phosphatase OCA1" /EC_number="3.1.3.48" /calculated_mol_wt="27074" Region 66..218 /region_name="PFA-DSP_Oca1" /note="atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 1; cd14531" /db_xref="CDD:350379" CDS 1..238 /gene="OCA1" /locus_tag="YNL099C" /coded_by="NM_001182937.3:1..717" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:40212001]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:11408586]" /note="Putative protein tyrosine phosphatase; contains phosphatase activity using the non-specific phosphatase substrate, pNPP, and is inhibited by sodium orthovanadate; required for cell cycle arrest in response to oxidative damage of DNA" /db_xref="GeneID:855624" /db_xref="SGD:S000005043" ORIGIN 1 mtskvgeyed vpedesrlte envsvpeeev ededeeeddd ddhiyineet esgrekvlvs 61 hapqerivpp lnfcpveryl yrsgqpspvn fpfllnlklk tiiwlsneep qdtllefcdt 121 hrinlqfaai npdageddnp wdgltehsii nvlqtivtqe nypllvccgm grhrtgtvig 181 clrrimgwnl asvseeyrrf tgsrggrilv ellieafdtn lvkidknkap swlltale // LOCUS NP_014301 322 aa linear PLN 30-JUN-2025 DEFINITION Ras family GTPase RAS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014301 VERSION NP_014301.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182936.1 REFERENCE 1 (residues 1 to 322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 322) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10447. Method: conceptual translation. FEATURES Location/Qualifiers source 1..322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..322 /product="Ras family GTPase RAS2" /EC_number="3.6.5.2" /calculated_mol_wt="34574" Region 9..172 /region_name="small_GTPase" /note="Small GTPase of the Ras superfamily; ill-defined subfamily; smart00010" /db_xref="CDD:197466" CDS 1..322 /gene="RAS2" /locus_tag="YNL098C" /gene_synonym="CTN5; CYR3; GLC5; TSL7" /coded_by="NM_001182936.1:1..969" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8106517]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:6438624]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23127800]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:22575457|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:22575457]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:23127800|PMID:11914276|PMID:20162532]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:15016820]" /experiment="EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:12782684]" /experiment="EXISTENCE:mutant phenotype:GO:0000411 positive regulation of transcription by galactose [PMID:16292676]" /experiment="EXISTENCE:mutant phenotype:GO:0010603 regulation of cytoplasmic mRNA processing body assembly [PMID:21925385]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:2558958]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:15016820]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:15917658]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:21925385]" /experiment="EXISTENCE:mutant phenotype:GO:2000222 positive regulation of pseudohyphal growth [PMID:1547504|PMID:8643578]" /note="GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication" /db_xref="GeneID:855625" /db_xref="SGD:S000005042" ORIGIN 1 mplnksnire yklvvvgggg vgksaltiql tqshfvdeyd ptiedsyrkq vviddevsil 61 dildtagqee ysamreqymr ngegfllvys itskssldel mtyyqqilrv kdtdyvpivv 121 vgnksdlene kqvsyqdgln makqmnapfl etsakqainv eeafytlarl vrdeggkynk 181 tltendnskq tsqdtkgsga nsvprnsggh rkmsnaangk nvnssttvvn arnasieskt 241 glagnqatng ktqtdrtnid nstgqagqan aqsantvnnr vnnnskagqv snakqarkqq 301 aapggntsea sksgsggcci is // LOCUS NP_878155 40 aa linear PLN 30-JUN-2025 DEFINITION Pls1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878155 VERSION NP_878155.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184620.1 REFERENCE 1 (residues 1 to 40) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 40) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 40) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 40) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 40) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10448. Method: conceptual translation. FEATURES Location/Qualifiers source 1..40 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..40 /product="Pls1p" /calculated_mol_wt="4491" CDS 1..40 /gene="PLS1" /locus_tag="YNL097C-B" /gene_synonym="YNL097C-A" /coded_by="NM_001184620.1:1..123" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:35563734]" /experiment="EXISTENCE:mutant phenotype:GO:1902986 regulation of lysine biosynthetic process via aminoadipic acid [PMID:35563734]" /note="Peroxisomal matrix protein that regulates lysine biosynthesis; localization to peroxisomes upon lysine deprivation is dependent on targeting factor Pex5p and lysine biosynthesis enzyme Lys1p; affects abundance of Lys1p and the lysine biosynthesis pathway" /db_xref="GeneID:1466513" /db_xref="SGD:S000028699" ORIGIN 1 mtaktkqswn kgiwengkqg shqqtflpki wvniystpts // LOCUS NP_014302 330 aa linear PLN 30-JUN-2025 DEFINITION Pho23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014302 VERSION NP_014302.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182935.3 REFERENCE 1 (residues 1 to 330) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 330) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 330) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 330) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10449. On Jul 30, 2012 this sequence version replaced NP_014302.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..330 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..330 /product="Pho23p" /calculated_mol_wt="36893" Region 5..330 /region_name="TNG2" /note="Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]; COG5034" /db_xref="CDD:227367" CDS 1..330 /gene="PHO23" /locus_tag="YNL097C" /coded_by="NM_001182935.3:1..993" /experiment="EXISTENCE:direct assay:GO:0000118 histone deacetylase complex [PMID:12672825]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286008|PMID:16286007|PMID:19040720|PMID:16314178]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:17142463]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:10805724]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19270272]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17210643|PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:18202364]" /note="Component of the Rpd3L histone deacetylase complex; involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus shares significant sequence identity with the human candidate tumor suppressor p33-ING1 and its isoform ING3" /db_xref="GeneID:855626" /db_xref="SGD:S000005041" ORIGIN 1 msspanlfpg lnditdvlee fplatsrylt llheidakcv hsmpnlneri dkflkkdfnk 61 dhqtqvrlln ninkiyeelm psleekmhvs simldnldrl tsrlelayev aiknteiprg 121 lrlgvdnhpa mhlhhelmek iesksnskss qalksesrre amaanrrqge hysasthqqd 181 dskndanygg srhesqdhtg nntnsrkran aantnnadpe tkkrkrrvat tavspstist 241 atavnngrig tstasrgvss vgnsnnsris rpktndygep lycycnqvay gemvgcdgad 301 celewfhlpc igletlpkgk wycddckkkl // LOCUS NP_014303 190 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS7 RPS7B [Saccharomyces cerevisiae S288C]. ACCESSION NP_014303 VERSION NP_014303.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182934.3 REFERENCE 1 (residues 1 to 190) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 190) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 190) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 190) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10450. On Jul 30, 2012 this sequence version replaced NP_014303.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..190 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..190 /product="40S ribosomal protein eS7 RPS7B" /calculated_mol_wt="21503" Region 7..185 /region_name="Ribosomal_S7e" /note="Ribosomal protein S7e; pfam01251" /db_xref="CDD:460135" CDS 1..190 /gene="RPS7B" /locus_tag="YNL096C" /coded_by="NM_001182934.3:1..573" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:genetic interaction:GO:0042254 ribosome biogenesis [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855628" /db_xref="SGD:S000005040" ORIGIN 1 mssvqskils qapselelqv aktfidless spelkadlrp lqiksireid vtggkkalvl 61 fvpvpalsay hkvqtkltre lekkfpdrhv iflaerrilp kpsrtsrqvq krprsrtlta 121 vhdkvledmv fpteivgkrv rylvggnkiq kvlldskdvq qidyklesfq avynkltgkq 181 ivfeipsqtn // LOCUS NP_014304 642 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL095C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014304 VERSION NP_014304.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182933.1 REFERENCE 1 (residues 1 to 642) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 642) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 642) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 642) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10451. Method: conceptual translation. FEATURES Location/Qualifiers source 1..642 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..642 /product="uncharacterized protein" /calculated_mol_wt="71065" Region 12..>174 /region_name="Mem_trans" /note="Membrane transport protein; cl22894" /db_xref="CDD:451441" CDS 1..642 /locus_tag="YNL095C" /coded_by="NM_001182933.1:1..1929" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; predicted to contain a transmembrane domain; not an essential gene; YNL095C has a paralog, ECM3, that arose from the whole genome duplication" /db_xref="GeneID:855629" /db_xref="SGD:S000005039" ORIGIN 1 mvhitlgqai wvsvkpiiki yliigvgflm akmgiltvea triisdivlt vllpslsfnk 61 ivaniedkdi ksvgiiclsa llifgsgfff ayvvrlflpv pkqwyggila ggmfpnisdl 121 piaylqsmdq glvfseeegn kgvanviifl tmflicifnl ggfrliesdf eynddesavr 181 vsettktqpa vsanttntdt serffsneqq lfnnkytard slteaigtkg enadvppisr 241 rstnsiapls lpdtssnski tkpvqvkarn tiactqsees qatrgsnpld sqssastihs 301 yntsesyess idtmrarrta sqpraynttt lleencldek cpknmsmaal epirsidmra 361 lpsqnihhli reysnvdqyg hqrrnsslrg admndvhsis snstlqtikt anltriltsd 421 atvskkdiet sgeslpqwmr kfsltpllvf flknclrpcs maviialtva fipwvkalfv 481 ttantphisq apdnapplsf fmdftgyvga acvpfglill gatlgrlkig nlypgfwkaa 541 vtlvilrqcv mpifgvlwcd rlvkagwvnw qddrmllfvi aiswnlptmt tliyftasft 601 ppettapiqm ecvsfflmlq yplmvvslpf lvsyflkvqm nl // LOCUS NP_014305 587 aa linear PLN 30-JUN-2025 DEFINITION phosphatidate phosphatase APP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014305 VERSION NP_014305.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182932.1 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10452. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..587 /product="phosphatidate phosphatase APP1" /EC_number="3.1.3.4" /calculated_mol_wt="66003" Region 278..426 /region_name="APP1_cat" /note="Phosphatidate phosphatase APP1, catalytic domain; pfam09949" /db_xref="CDD:462930" CDS 1..587 /gene="APP1" /locus_tag="YNL094W" /coded_by="NM_001182932.1:1..1764" /experiment="EXISTENCE:direct assay:GO:0008195 phosphatidate phosphatase activity [PMID:23071111|PMID:23335564]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:11489916]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:23071111]" /experiment="EXISTENCE:mutant phenotype:GO:0008195 phosphatidate phosphatase activity [PMID:23071111]" /note="Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway" /db_xref="GeneID:855630" /db_xref="SGD:S000005038" ORIGIN 1 mnsqgydess sstaatsgpt sgdprmgkkq rfmnlirttk dvyipnltss isqktmdgir 61 sttnsfegyn dlpmelphnt tityfptytt tnlvdpdgls aprkdfettv rcavsypgnp 121 tsrrnrwlls lckqylrtgt aeadvapvvp phleedsgdl ndsqssiess lssksenrys 181 hmgiqeedvl neriqgflsk kvpntpvvvd llpkdklrgd tasffgttds ygnllikaet 241 dflpskinit ldtpieghad pisetfpany vspygiglis diddtikhtg vtgdrrsmfr 301 nvfihdvqsw vidgvplwyk tlhdvadvdf fyvsnspiqt ftllkqyica nfppgpiflk 361 qysgnffsti mtssanrkiq pianilkdfp kkkfilvgds gehdleaytt talqfpnqil 421 aiyirccsns msdvpshdee vmnevnniie lqqrpmqmtk stvrtrrrpp pppipstqkp 481 slteeqtesi rmsrrnkden nakrvapppl pnrqlpnlda ntyyvpssqn dygmygafmd 541 kkadewkrrv mdsiqklsnq dttlmffsdp alsledsirr irekysn // LOCUS NP_014306 220 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase YPT53 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014306 VERSION NP_014306.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182931.3 REFERENCE 1 (residues 1 to 220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 220) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10453. On Jul 30, 2012 this sequence version replaced NP_014306.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..220 /product="Rab family GTPase YPT53" /calculated_mol_wt="24517" Region 12..180 /region_name="Rab5_related" /note="Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion; cd01860" /db_xref="CDD:206653" Site 12..14 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206653" Site 19..26 /site_type="other" /note="G1 box" /db_xref="CDD:206653" Site order(21..27,37..38,43..44,70,125..126,128,161..163) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206653" Site order(27..38,42..43) /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206653" Site order(37,42..50) /site_type="other" /note="Switch I region" /db_xref="CDD:206653" Site order(42,46..53,60,62) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206653" Site 44 /site_type="other" /note="G2 box" /db_xref="CDD:206653" Site order(45..46,48,66..67,74,76,78..80) /site_type="other" /note="putative GDI interaction site [polypeptide binding]" /db_xref="CDD:206653" Site 45..49 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206653" Site order(47..49,51,73,80..81) /site_type="active" /note="effector interaction site [active]" /db_xref="CDD:206653" Site 62..66 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206653" Site 67..70 /site_type="other" /note="G3 box" /db_xref="CDD:206653" Site order(70,72..82) /site_type="other" /note="Switch II region" /db_xref="CDD:206653" Site 73..78 /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206653" Site 81..82 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206653" Site 90..95 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206653" Site 117..122 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206653" Site 125..128 /site_type="other" /note="G4 box" /db_xref="CDD:206653" Site 161..163 /site_type="other" /note="G5 box" /db_xref="CDD:206653" Site 177..179 /site_type="other" /note="Rab subfamily motif 4 (RabSF4)" /db_xref="CDD:206653" CDS 1..220 /gene="YPT53" /locus_tag="YNL093W" /coded_by="NM_001182931.3:1..663" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:22748138]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:8163546]" /experiment="EXISTENCE:mutant phenotype:GO:0005770 late endosome [PMID:11872141]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8163546]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8163546]" /note="Stress-induced Rab family GTPase; required for vacuolar protein sorting and endocytosis; involved in ionic stress tolerance; similar to Vps21p and Ypt52p; functional homolog of Vps21p; mammalian Rab5 homolog; YPT53 has a paralog, VPS21, that arose from the whole genome duplication" /db_xref="GeneID:855631" /db_xref="SGD:S000005037" ORIGIN 1 mdkhtaaipt ltikvvllge savgkssivl rfvsddfkes keptigaafl tkritrdgkv 61 ikfeiwdtag qerfaplapm yyrnaqaalv vfdvtnegsf ykaqnwveel hekvghdivi 121 alvgnkmdll nnddenenra mkapavqnlc erenllyfea saktgeniyq ifqtlgekvp 181 cpeqntrqss thdrtitdnq ridlesttve stretggcnc // LOCUS NP_014307 400 aa linear PLN 30-JUN-2025 DEFINITION S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014307 VERSION NP_014307.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182930.1 REFERENCE 1 (residues 1 to 400) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 400) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 400) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 400) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10454. Method: conceptual translation. FEATURES Location/Qualifiers source 1..400 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..400 /product="S-adenosylmethionine-dependent methyltransferase" /EC_number="2.1.1.22" /calculated_mol_wt="45366" Region 88..396 /region_name="CARME" /note="Carnosine N-methyltransferase; pfam07942" /db_xref="CDD:400340" CDS 1..400 /locus_tag="YNL092W" /coded_by="NM_001182930.1:1..1203" /experiment="EXISTENCE:direct assay:GO:0006479 protein methylation [PMID:24651469]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:24651469]" /note="S-adenosylmethionine-dependent protein methyltransferase; capable of automethylation; member of the seven beta-strand family; YNL092W is not an essential gene" /db_xref="GeneID:855632" /db_xref="SGD:S000005036" ORIGIN 1 mdenefdnqr enkavarvii sflkyeeyal keiynlrvkk wasisdrqkd mvpnytkyla 61 nlkaaiieng kffrsvaeya lqsisfepge ivqpndldms ktcslltqvy rewsaeaise 121 rnclnsrlvp flktlsppka dilipgcgtg rllvdlsrmg yncegnefsy hmllvsqyml 181 nagllqnqii iypfihcfsh wkkiedqlsp ikvpdieaws snkgmgsmsi cagsfvdcyg 241 rnqgtkissh ytfsrrmqls rakaenskdv vvtnffidtg snildyldti ghvlkpggiw 301 cnfgpllyhf endhgvetty evnpysgfqd kindytplmg lelssddiis iatnhldfel 361 irresgilcg ygryagpesc ampgymchyw ilksnptnes // LOCUS NP_014308 1240 aa linear PLN 30-JUN-2025 DEFINITION Nst1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014308 VERSION NP_014308.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182929.1 REFERENCE 1 (residues 1 to 1240) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1240) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1240) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1240) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10455. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1240 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1240 /product="Nst1p" /calculated_mol_wt="141383" Region <103..159 /region_name="NST1" /note="Salt tolerance down-regulator; pfam13945" /db_xref="CDD:372833" Region <694..>727 /region_name="ARGLU" /note="Arginine and glutamate-rich 1; pfam15346" /db_xref="CDD:405931" CDS 1..1240 /gene="NST1" /locus_tag="YNL091W" /coded_by="NM_001182929.1:1..3723" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:34347506]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0017148 negative regulation of translation [PMID:34347506]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:11816027]" /note="Translational inhibitor and suppressor of proteasome-assembly defects; P-body component that inhibits translation, rescues proteasome base assembly defects and aggregation of regulatory particle subunits during stress when overexpressed; proposed to function to bridge the HOG and pheromone pathways with the cell wall integrity pathway in response to heat stress; interacts physically and genetically with splicing factor MSL1; large, highly-charge protein containing many disordered regions" /db_xref="GeneID:855633" /db_xref="SGD:S000005035" ORIGIN 1 mppnskskrr knkskqhnkk ngnsdpeqsi nptqlvprme pelyhtesdy ptsrvikrap 61 ngdvivepin tdddkkerta nlthnkdsmd sasslaftld shweslspee kktilrieke 121 evfnvirnyq ddhscscsvc grrhlamdqe meriyntlya mdkdkdpetn pikfhlgiik 181 elqisknqqq ndlsstkgev vknflssstv gslkeevlhf kqkqlskqeq ahnetadnts 241 lleenlnnih inktsseisa nfnsvsdeel qqkysnftkt fisshpkiae eyvqkmmmyp 301 niraltddlm nsngqgflna iedfvrdgqi qaskkddsit edeasstdlt dpkefttmlh 361 sgkpltedey adlqrniaer mtnaydtask kfkdvsqlek elftrfmsgr dkksfrelii 421 qsfknkfdge lgpsvlaatl sscfssqskd tsldtdsiye dedeedyddy seyaedseev 481 seyegieave kpehdeksng iretlhlsyd hdhkrqnhph hhyhstsths edelseeeyi 541 sdielphdph khfhrdddil dgdedepeee denegddeed tydsgldetd rleegrkliq 601 iaitkllqsr imasyhekqa dnnrlkllqe leeekrkkre keekkqkkre kekekkrlqq 661 lakeeekrkr eeekerlkke leeremrrre aqrkkveeak rkkdeerkrr leeqqrreem 721 qekqrkqkee lkrkreeekk rireqkrleq eklqkekeee erqrliaeda lrkqklneeq 781 tsanilsakp ftengvgnpv ssqshpnmtn yqednscsin deilkmvnsv aaskpvsptg 841 fnvhdlllps tnnqmpameq shlpqpgnqn nhfgtttipn aldlatkssl qtennylmns 901 qtlentsllm hnnssptkll pndfglsswg gltntmsinp tckppviqts emesqahkss 961 pqatmpsfgl pnggthrksf tdelntltsm lsssgfadts lsssgfppsq rsvwndqkss 1021 fsgpstagnf nnssiqsgml laptlgsves fpnrtsiwds sttpmmnkse lsgrnitsta 1081 qdspafmasn iwssnsqyns pyltsnvlqs pqissgvdes hildsiynty laispqdsln 1141 pyiaigtlfq nlvglnldys tfinklismq gayncefftd nngsithvrf arqtpaghsk 1201 gllnqlfsgl ndptatpfts rphtstrasf piassttqts // LOCUS NP_014309 192 aa linear PLN 30-JUN-2025 DEFINITION Rho family GTPase RHO2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014309 VERSION NP_014309.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182928.3 REFERENCE 1 (residues 1 to 192) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 192) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 192) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 192) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10456. On Jul 30, 2012 this sequence version replaced NP_014309.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..192 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..192 /product="Rho family GTPase RHO2" /EC_number="3.6.5.2" /calculated_mol_wt="21348" Region 7..191 /region_name="Rho2" /note="Ras homology family 2 (Rho2) of small guanosine triphosphatases (GTPases); cd04129" /db_xref="CDD:206702" Site order(9,39..40,42..43,45,47,56,60..61,63..65,71,74) /site_type="other" /note="putative GEF (guanine nucleotide exchange factor) interaction site [polypeptide binding]" /db_xref="CDD:206702" Site 14..21 /site_type="other" /note="G1 box" /db_xref="CDD:206702" Site order(17..22,61..62,64,120,122,160..161) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206702" Site 38..44 /site_type="other" /note="Switch I region" /db_xref="CDD:206702" Site 39 /site_type="other" /note="G2 box" /db_xref="CDD:206702" Site order(40,63,68,70..71,73) /site_type="active" /note="putative GDI (guanine nucleotide dissociation inhibitor) interaction [active]" /db_xref="CDD:206702" Site order(40..41,65,71) /site_type="other" /note="putative GAP (GTPase-activating protein) interaction site [polypeptide binding]" /db_xref="CDD:206702" Site order(41..42,71,74) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206702" Site 61..64 /site_type="other" /note="G3 box" /db_xref="CDD:206702" Site order(64..65,71..74,79..81) /site_type="other" /note="Switch II region" /db_xref="CDD:206702" Site 119..122 /site_type="other" /note="G4 box" /db_xref="CDD:206702" Site 159..161 /site_type="other" /note="G5 box" /db_xref="CDD:206702" Site 188..191 /site_type="other" /note="putative lipid modification site [posttranslational modification]" /db_xref="CDD:206702" CDS 1..192 /gene="RHO2" /locus_tag="YNL090W" /coded_by="NM_001182928.3:1..579" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:10526184|PMID:11591390]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:18417612]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Non-essential small GTPase of the Rho/Rac family of Ras-like proteins; involved in the establishment of cell polarity and in microtubule assembly" /db_xref="GeneID:855634" /db_xref="SGD:S000005034" ORIGIN 1 msekavrrkl viigdgacgk tsllyvftlg kfpeqyhptv fenyvtdcrv dgikvsltlw 61 dtagqeeyer lrpfsyskad iiligfavdn feslinartk wadealrycp dapivlvglk 121 kdlrqeahfk enatdemvpi edakqvarai gakkymecsa ltgegvddvf evatrtsllm 181 kkepgancci il // LOCUS NP_014311 1428 aa linear PLN 30-JUN-2025 DEFINITION DNA topoisomerase 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014311 VERSION NP_014311.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182926.3 REFERENCE 1 (residues 1 to 1428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1428) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10457. On Jul 30, 2012 this sequence version replaced NP_014311.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1428 /product="DNA topoisomerase 2" /EC_number="5.6.2.2" /calculated_mol_wt="164084" Region 10..1428 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" CDS 1..1428 /gene="TOP2" /locus_tag="YNL088W" /gene_synonym="TOR3; TRF3" /coded_by="NM_001182926.3:1..4287" /experiment="EXISTENCE:direct assay:GO:0000795 synaptonemal complex [PMID:1315786]" /experiment="EXISTENCE:direct assay:GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity [PMID:6323017|PMID:6088500]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:6088500|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:6088500]" /experiment="EXISTENCE:direct assay:GO:0097047 DNA replication termination region [PMID:20797631]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:25430478]" /experiment="EXISTENCE:genetic interaction:GO:0009303 rRNA transcription [PMID:2436053]" /experiment="EXISTENCE:mutant phenotype:GO:0000019 regulation of mitotic recombination [PMID:2902925]" /experiment="EXISTENCE:mutant phenotype:GO:0006265 DNA topological change [PMID:31969709]" /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:2549254]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:9199287]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:2156624]" /experiment="EXISTENCE:mutant phenotype:GO:0031055 chromatin remodeling at centromere [PMID:18701701]" /experiment="EXISTENCE:mutant phenotype:GO:0097046 replication fork progression beyond termination site [PMID:20797631]" /note="Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant" /db_xref="GeneID:855636" /db_xref="SGD:S000005032" ORIGIN 1 mstepvsasd kyqkisqleh ilkrpdtyig svetqeqlqw iydeetdcmi eknvtivpgl 61 fkifdeilvn aadnkvrdps mkridvniha eehtievknd gkgipieihn keniyipemi 121 fghlltssny dddekkvtgg rngygaklcn ifstefilet adlnvgqkyv qkwennmsic 181 hppkitsykk gpsytkvtfk pdltrfgmke ldndilgvmr rrvydingsv rdinvylngk 241 slkirnfkny velylkslek krqldngedg aaksdiptil yerinnrwev afavsdisfq 301 qisfvnsiat tmggthvnyi tdqivkkise ilkkkkkksv ksfqiknnmf ifinclienp 361 aftsqtkeql ttrvkdfgsr ceipleyink imktdlatrm feiadaneen alkksdgtrk 421 sritnypkle dankagtkeg ykctlvlteg dsalslavag lavvgrdyyg cyplrgkmln 481 vreasadqil knaeiqaikk imglqhrkky edtkslrygh lmimtdqdhd gshikgliin 541 flessfpgll diqgfllefi tpiikvsitk ptkntiafyn mpdyekwree eshkftwkqk 601 yykglgtsla qevreyfsnl drhlkifhsl qgndkdyidl afskkkaddr kewlrqyepg 661 tvldptlkei pisdfinkel ilfsladnir sipnvldgfk pgqrkvlygc fkknlkselk 721 vaqlapyvse ctayhhgeqs laqtiiglaq nfvgsnniyl llpngafgtr atggkdaaaa 781 ryiytelnkl trkifhpadd plykyiqede ktvepewylp ilpmilvnga egigtgwsty 841 ippfnpleii knirhlmnde eleqmhpwfr gwtgtieeie plryrmygri eqigdnvlei 901 telpartwts tikeylllgl sgndkikpwi kdmeeqhddn ikfiitlspe emaktrkigf 961 yerfklispi slmnmvafdp hgkikkynsv neilsefyyv rleyyqkrkd hmserlqwev 1021 ekysfqvkfi kmiiekeltv tnkprnaiiq elenlgfprf nkegkpyygs pndeiaeqin 1081 dvkgatsdee deesshedte nvingpeely gtyeyllgmr iwsltkeryq kllkqkqeke 1141 telenllkls akdiwntdlk afevgyqefl qrdaearggn vpnkgsktkg kgkrklvdde 1201 dydpskknkk starkgkkik ledknferil leqklvtksk aptkikkekt psvsetktee 1261 eenapsstss ssifdikked kdegelskis nkfkkistif dkmgstsats kentpeqddv 1321 atkknqttak ktavkpklak kpvrkqqkvv elsgesdlei ldsytdreds nkdeddaipq 1381 rsrrqrssra asvpkksyve tlelsddsfi eddeeenqgs dvsfneed // LOCUS NP_014312 1178 aa linear PLN 30-JUN-2025 DEFINITION tricalbin [Saccharomyces cerevisiae S288C]. ACCESSION NP_014312 VERSION NP_014312.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182925.1 REFERENCE 1 (residues 1 to 1178) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1178) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1178) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1178) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10458. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1178 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1178 /product="tricalbin" /calculated_mol_wt="132379" Region 4..1178 /region_name="COG5038" /note="Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]" /db_xref="CDD:227371" CDS 1..1178 /gene="TCB2" /locus_tag="YNL087W" /coded_by="NM_001182925.1:1..3537" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:22250200]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:22250200]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0055091 phospholipid homeostasis [PMID:35440494]" /experiment="EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]" /experiment="EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:33205016]" /note="Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane (PM); regulates PI4P levels by controlling access of Sac1p to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3 calcium and lipid binding domains; localizes to the cortical ER, the cell periphery and is enriched in bud membranes; mRNA is targeted to the bud tip" /db_xref="GeneID:855637" /db_xref="SGD:S000005031" ORIGIN 1 mspnssktrt dqissmpgin eatkvesknv vkdavpikse vetngtsivr ekqdpsyvgw 61 kqvggweekd eltsedllvd vnkdtflgnl lpdkfygdwy hevailiiag lcsfvlgyfk 121 fslasvlivm lttgmlyrts skkyreslrd laqkeqtvek itsdyesvew lntfldkywp 181 iiepsvsqqi vdgtntalse nvaipkfika iwldqftlgv kppridaikt fqntksdvvv 241 mdvclsftph dmsdldakqc rnyvnsnvvl kakifgmdip vsvadiffqv fvrfrfqlmt 301 tlplvetini qllevpevdf isrllgnsvf nweilaipgl mrliqkmafk ylspvllppf 361 slqlnipqll sktglpigvl eikvknahgl rklvgmikkt vdpyltfels gkivgktkvf 421 knsanpvwne siyillqsft dpltiavydk retlsdkkmg tvifnlnklh anhyhknekv 481 hflrnskpvg eltfdlrffp tiepkkllng deeplpdmnt gitkitirel kgldelsdkk 541 fvfaelyvna elvmttkkek rtahlkwnsd yysvvtdrrk ticrfvlkdq sgkvisssvq 601 plnhlidrte vnkewiplrn gkgelkvtty wrpvdidlgl ksvgyttpig mlrvfinkae 661 nlrnpdslgk ispyakvsvn gvargrtner ietlnpiwnq siyvsvtspl qkvsidcfgi 721 dtngddhnlg slniqtqniy hkdnddkyti fidnaprtgn ligkkgvkgt vtyylsfypv 781 vpvlsleeak evdeinekkd klekqkstld dkniskeeke rikkeefrlt ekydmysykm 841 kldldellqy nagvlgvtvl ggelpqpgly vqtffdscgy aaitsaknai rtiktgwsgd 901 fmikelewsv ttfrvtktkd ankaenfice vniptielvr ncyykpsvln ligkksakll 961 vqvswfpvta telpqsdlit nsgdlkitak saenligvnk ngysdpyvef flnekstspf 1021 fktavqkktl nptwneskti evsnrvndyl tinvkdyest nsnrsigkav vplstidpes 1081 dttfniplvg pkgedggvlh lefefepryt tnvvkreagl gnfatkglgt gikagstvfa 1141 lgtnvvstgl gtidkvkagv fggkkstttg dkkseekq // LOCUS NP_014313 102 aa linear PLN 30-JUN-2025 DEFINITION Snn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014313 VERSION NP_014313.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182924.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10459. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..102 /product="Snn1p" /calculated_mol_wt="11330" CDS 1..102 /gene="SNN1" /locus_tag="YNL086W" /coded_by="NM_001182924.1:1..309" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031083 BLOC-1 complex [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0007032 endosome organization [PMID:23547030]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:23547030]" /note="Subunit of the BLOC-1 complex involved in endosomal maturation; interacts with Msb3p; green fluorescent protein (GFP)-fusion protein localizes to endosomes" /db_xref="GeneID:855638" /db_xref="SGD:S000005030" ORIGIN 1 magdsisadg tgvhpvelsv ysvlstdldg lyqsinelre sqallilmlr kvrdklrreg 61 qvlydpepfk ptmdkladls arvrilsqry eelqgnaral nn // LOCUS NP_014314 830 aa linear PLN 30-JUN-2025 DEFINITION Mkt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014314 VERSION NP_014314.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182923.3 REFERENCE 1 (residues 1 to 830) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 830) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 830) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 830) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 830) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10460. On Jul 30, 2012 this sequence version replaced NP_014314.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..830 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..830 /product="Mkt1p" /calculated_mol_wt="94364" Region 10..746 /region_name="COG5366" /note="Protein involved in propagation of M2 dsRNA satellite of L-A virus [General function prediction only]" /db_xref="CDD:227661" CDS 1..830 /gene="MKT1" /locus_tag="YNL085W" /coded_by="NM_001182923.3:1..2493" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:24970865]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:18617998]" /note="Putative nuclease that forms a complex with Pbp1p; involved in posttranscriptional regulation of HO, propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, stress responses through posttranscriptional modulation of Puf3p targets; forms cytoplasmic foci upon DNA replication stress; localization to P-bodies under ethanol stress differs between strains" /db_xref="GeneID:855639" /db_xref="SGD:S000005029" ORIGIN 1 maikslesfl ferglvgsya iealnnctld idvnhyvsrl ltnkreqyld aiggfptslk 61 mylesdlkif kdfnitpifv fnggltynql easghftaas asasissttt sssgtnattr 121 sntesvllqr srgwtqwnnl issnqnsyid qpiqpqepfr hnttidskay qndliayfie 181 hgymyqvapy sswfqlayll nsayidaiyg ptdclmldcv drfilgmefp nkefrfidrs 241 rvmkdlgcth eefidiamav gndlqpttlp plqiypvpql fdialemvln tgtnfyayql 301 sttlqndske niqnyqrgis alrympvlkd tgkvelfvqe ivvseedsek nnkdgkksnl 361 sspssasssa spattvtkna sekltyekss tkevrkprdi pndvhdfigq mlpheyyfyr 421 siglvtgklf daivtgvype epplgggsst sykklvsksv eifknkeinl ltqpinryyq 481 ikqikqvkwy aanepttltn rmspsmfeti nhlivktets dekefsisef ittingssnm 541 akdfisekvi fpnsvpiesk lnspfnllst nflrllvlle fftfdfkekl leptrwgevf 601 lklnelnids kyhesviifl vflkcdvlkl deevqppaps alsqatlrsy peeslyvlli 661 trvltlfqvd qkpsnyhgpi dkktlifrdh lsfikenlne lfeavlissl tsgefnrlsl 721 dnfgwarkiv rylpfkldsp ntimammwef flqkylhngn akndalslva tefntykstp 781 nldeqfvesh rflleiskvm qelnaaklid envfklftka veftttalss // LOCUS NP_014315 349 aa linear PLN 30-JUN-2025 DEFINITION End3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014315 VERSION NP_014315.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182922.1 REFERENCE 1 (residues 1 to 349) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 349) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 349) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 349) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10461. Method: conceptual translation. FEATURES Location/Qualifiers source 1..349 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..349 /product="End3p" /calculated_mol_wt="40166" Region 1..104 /region_name="EF-hand_4" /note="Cytoskeletal-regulatory complex EF hand; pfam12763" /db_xref="CDD:289529" Region 123..221 /region_name="EH" /note="Eps15 homology domain; smart00027" /db_xref="CDD:197477" Region 186..345 /region_name="End3" /note="Actin cytoskeleton-regulatory complex protein END3; pfam12761" /db_xref="CDD:432765" CDS 1..349 /gene="END3" /locus_tag="YNL084C" /coded_by="NM_001182922.1:1..1050" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990964 actin cytoskeleton-regulatory complex [PMID:17151356|PMID:10594004]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:35101986]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:35101986]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8380177]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15944351]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:10594004]" /experiment="EXISTENCE:physical interaction:GO:1990964 actin cytoskeleton-regulatory complex [PMID:17151356]" /note="EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p" /db_xref="GeneID:855640" /db_xref="SGD:S000005028" ORIGIN 1 mpkleqfeik kywqifsglk pienkvnhdq vlpilynskl dssvlnkiwf ladiddddnl 61 dfeefvicmr lifdmvnkni ssvpdelpdw lipgskvnli kerkkrkqie nadlppkkei 121 kvdwymspdd lnqyekiyns cakltdgtit fnelstklst kffnisktdl nkvwslinpq 181 nlpsidrdpt fyfihclrqr ndlgaeipas lpnslaevcn kkqlsydlrs sqpptkrkee 241 anevdnlrdn gqnsssdssg snvlsnedsi kqkyasltdd qvanmreqle gllnykksek 301 tqggsklskr inirsitddl dnieqqvevl enylnnkrhe lqalqaein // LOCUS NP_014316 494 aa linear PLN 30-JUN-2025 DEFINITION Ca(2+)-binding ATP:ADP antiporter SAL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014316 VERSION NP_014316.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182921.1 REFERENCE 1 (residues 1 to 494) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 494) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 494) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 494) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10462. On May 17, 2010 this sequence version replaced NP_014316.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..494 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..494 /product="Ca(2+)-binding ATP:ADP antiporter SAL1" /calculated_mol_wt="55616" Region <19..111 /region_name="FRQ1" /note="Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]; COG5126" /db_xref="CDD:444056" Region 231..335 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 343..>402 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..494 /gene="SAL1" /locus_tag="YNL083W" /coded_by="NM_001182921.1:1..1485" /experiment="EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:15238515]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0005471 ATP:ADP antiporter activity [PMID:18485069]" /experiment="EXISTENCE:mutant phenotype:GO:0006839 mitochondrial transport [PMID:18485069]" /experiment="EXISTENCE:mutant phenotype:GO:0015866 ADP transport [PMID:18485069]" /experiment="EXISTENCE:mutant phenotype:GO:0015867 ATP transport [PMID:18485069]" /note="ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains" /db_xref="GeneID:855641" /db_xref="SGD:S000005027" ORIGIN 1 mllkncetdk qrdiryaclf keldvkgngq vtldnlisaf ekndhplkgn deaikmlfta 61 mdvnkdsvvd lsdfkkyasn aesqiwngfq ridldhdgki gineinryls dldnqsicnn 121 elnhelsnek mnkfsrffew afpkrkania lrgqashkkn tdndrskktt dsdlyvtydq 181 wrdflllvpr kqgsrlhtay syfylfnedv dlssegdvtl indfirgfgf fiaggisgvi 241 srtctapfdr lkvfliartd lssillnskt dllaknpnad inkissplak avkslyrqgg 301 ikafyvgngl nvikvfpess ikfgsfevtk kimtklegcr dtkdlskfst yiagglagma 361 aqfsvypidt lkfrvqcapl dtklkgnnll fqtakdmfre gggqiilqrc hsrysghisl 421 ccirfgdffc lkkmvycqtg kdpepttrsg hskqpgctsn gciqwncrsf cclsnqsfkn 481 kttsprnict slcv // LOCUS NP_014317 873 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding mismatch repair protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_014317 VERSION NP_014317.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182920.3 REFERENCE 1 (residues 1 to 873) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 873) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 873) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 873) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 873) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 873) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 873) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 873) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10463. On Jul 30, 2012 this sequence version replaced NP_014317.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..873 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..873 /product="ATP-binding mismatch repair protein" /calculated_mol_wt="99225" Region 2..337 /region_name="mutl" /note="DNA mismatch repair protein MutL; TIGR00585" /db_xref="CDD:273155" Region 676..826 /region_name="MutL_C" /note="MutL C terminal dimerisation domain; smart00853" /db_xref="CDD:214857" CDS 1..873 /gene="PMS1" /locus_tag="YNL082W" /coded_by="NM_001182920.3:1..2622" /experiment="EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:9368761]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:11575920]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:11575920]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:11717305]" /experiment="EXISTENCE:direct assay:GO:0032135 DNA insertion or deletion binding [PMID:9368761]" /experiment="EXISTENCE:direct assay:GO:0032139 dinucleotide insertion or deletion binding [PMID:9368761]" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:16702432]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:10938116]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:2685551]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:11717305]" /experiment="EXISTENCE:physical interaction:GO:0032389 MutLalpha complex [PMID:8066446|PMID:10570173|PMID:11237696]" /note="ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain; required for silencing at the silent mating-type loci and telomeres; similar to E. coli MutL" /db_xref="GeneID:855642" /db_xref="SGD:S000005026" ORIGIN 1 mtqihqindi dvhritsgqv itdlttavke lvdnsidana nqieiifkdy glesiecsdn 61 gdgidpsnye flalkhytsk iakfqdvakv qtlgfrgeal sslcgiakls vitttsppka 121 dkleydmvgh itsktttsrn kgttvlvsql fhnlpvrqke fsktfkrqft kcltviqgya 181 iinaaikfsv wnitpkgkkn lilstmrnss mrknissvfg aggmrgleev dlvldlnpfk 241 nrmlgkytdd pdfldldyki rvkgyisqns fgcgrnskdr qfiyvnkrpv eystllkccn 301 evyktfnnvq fpavflnlel pmslidvnvt pdkrvillhn eravidifkt tlsdyynrqe 361 lalpkrmcsq seqqaqkrlk tevfddrstt hesdnenyht arsesnqsnh ahfnsttgvi 421 dksngtelts vmdgnytnvt dvigsecevs vdssvvldeg nsstptkklp siktdsqnls 481 dlnlnnfsnp efqnitspdk arslekvvee pvyfdidgek fqekavlsqa dglvfvdnec 541 hehtndcchq errgstdteq ddeadsiyae iepveinvrt plknsrksis kdnyrslsdg 601 lthrkfedei leynlstknf keiskngkqm ssiiskrkse aqeniiknkd eledfeqgek 661 yltltvsknd fkkmevvgqf nlgfiivtrk vdnkydlfiv dqhasdekyn fetlqavtvf 721 ksqkliipqp velsvidelv vldnlpvfek ngfklkidee eefgsrvkll slptskqtlf 781 dlgdfnelih likedgglrr dnircskirs mfamracrss imigkplnkk tmtrvvhnls 841 eldkpwncph grptmrhlme lrdwssfskd yei // LOCUS NP_014318 143 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS13m SWS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014318 VERSION NP_014318.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182919.3 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10464. On Jul 30, 2012 this sequence version replaced NP_014318.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..143 /product="mitochondrial 37S ribosomal protein uS13m SWS2" /calculated_mol_wt="15958" Region 3..113 /region_name="RpsM" /note="Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; COG0099" /db_xref="CDD:439869" CDS 1..143 /gene="SWS2" /locus_tag="YNL081C" /gene_synonym="uS13m" /coded_by="NM_001182919.3:1..432" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:28154081|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /note="Component of mitochondrial small ribosomal subunit; similar to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency; localizes to vacuole in response to H2O2; localizes to peroxisomes in glucose-growing cells" /db_xref="GeneID:855643" /db_xref="SGD:S000005025" ORIGIN 1 mvvhilgkgf kgkevikial askfygigkt taekicsklg fypwmrmhql sepqimsias 61 elstmtiegd araivkdnia lkrkigsysg mrhtlhlpvr gqhtrnnakt arklnkidrr 121 gihtfsqakv qhnpslwsci fgk // LOCUS NP_014319 366 aa linear PLN 30-JUN-2025 DEFINITION Eos1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014319 VERSION NP_014319.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182918.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10465. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..366 /product="Eos1p" /calculated_mol_wt="41543" Region 135..343 /region_name="EOS1" /note="N-glycosylation protein; pfam12326" /db_xref="CDD:432482" CDS 1..366 /gene="EOS1" /locus_tag="YNL080C" /coded_by="NM_001182918.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17187761]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:17187761]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17187761]" /note="Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene" /db_xref="GeneID:855644" /db_xref="SGD:S000005024" ORIGIN 1 mtwilstgmg phedkyakhe ratfkktyss mktlslnhlt akqhmlmalc rdisllpplt 61 yiftslrkaw rvsmrtsitl yepqslrdaf tyfwqklnsa ydnnssfega sqkavngdgk 121 dslllsaltt araseyllcs lwclvslyls yaildslmvr wivkystvaa ilrmfsmsli 181 ivtlelllls slspeldyfl htwiliscvl tavyiwqsyl tsdlryirnq egevqedtnv 241 peetedyedg eddadedshv vvadestvdv psndslsdns dgglfpvnrp svshsqspkr 301 pkkypkkafn fttkrtidly kitvlcvvpv glasfitmlg llrnlfiqrl dveqlerilh 361 emhppa // LOCUS NP_014320 199 aa linear PLN 30-JUN-2025 DEFINITION tropomyosin TPM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014320 VERSION NP_014320.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182917.1 REFERENCE 1 (residues 1 to 199) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 199) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 199) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 199) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 199) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10466. Method: conceptual translation. FEATURES Location/Qualifiers source 1..199 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..199 /product="tropomyosin TPM1" /calculated_mol_wt="23410" Region 7..186 /region_name="Tropomyosin_1" /note="Tropomyosin like; pfam12718" /db_xref="CDD:403808" CDS 1..199 /gene="TPM1" /locus_tag="YNL079C" /coded_by="NM_001182917.1:1..600" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:9864365]" /experiment="EXISTENCE:direct assay:GO:0003786 actin lateral binding [PMID:11457840]" /experiment="EXISTENCE:direct assay:GO:0005884 actin filament [PMID:7844152]" /experiment="EXISTENCE:direct assay:GO:0032432 actin filament bundle [PMID:2649250|PMID:9864365]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:9864365]" /experiment="EXISTENCE:genetic interaction:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:12419188]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:7844152|PMID:2649250|PMID:17237521]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:15645503]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:17237521]" /note="Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication" /db_xref="GeneID:855645" /db_xref="SGD:S000005023" ORIGIN 1 mdkireklsn lkleaeswqe kyeelkeknk dleqenveke nqiksltvkn qqledeiekl 61 eaglsdskqt eqdnvekenq iksltvknhq leeeieklea elaeskqlse dshhlqsnnd 121 nfskknqqle edleesdtkl ketteklres dlkadqlerr vaaleeqree werkneeltv 181 kyedakkeld eiaaslenl // LOCUS NP_014321 407 aa linear PLN 30-JUN-2025 DEFINITION Nis1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014321 VERSION NP_014321.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182916.3 REFERENCE 1 (residues 1 to 407) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 407) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 407) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10467. On Jul 30, 2012 this sequence version replaced NP_014321.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..407 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..407 /product="Nis1p" /calculated_mol_wt="45778" CDS 1..407 /gene="NIS1" /locus_tag="YNL078W" /gene_synonym="JIP1" /coded_by="NM_001182916.3:1..1224" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:25416945|PMID:30341817]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11817649]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:27385335|PMID:11817649]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:25416945]" /experiment="EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:30341817]" /experiment="EXISTENCE:direct assay:GO:0032177 cellular bud neck split septin rings [PMID:30341817]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:30341817]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:29074565]" /experiment="EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:29074565]" /experiment="EXISTENCE:physical interaction:GO:0140014 mitotic nuclear division [PMID:11817649]" /note="Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited with Nba1p to the cell cortex and to cytokinesis remnants (bud scars) by Aim44p and Nap1p where Nba1p prevents Rsr1p-mediated activation of Cdc24p, and therefore Cdc42p activation; acts with Nba1p to establish transient bud scar localization of Rga1p, a Cdc42p GAP; localizes to the nucleus and to cell division site during G2/M, and is then stably recruited to cytokinesis remnants" /db_xref="GeneID:855646" /db_xref="SGD:S000005022" ORIGIN 1 metyetsigt qsypptlfpp plgtggftts gyihalvdst snsnsnsntn sntnsntnsn 61 sdtkipivqi sddshithds fkpymeyhda shlrnrnisk adqvestevm eqftqwsnyk 121 mrsrsptina kpirhtsqrr tdftsknels kfsknhnfif hkgflkrqhs irredrqakv 181 rsrfrskkel tsvlnyiele qmdianvlas qpvnlhairn ltsrdpavtp ipflrsqmya 241 tssrppylrn rsisrklpks qpgslpttmp atatktikqn sttpttrsvy nknvgrsnts 301 psvlyhpkrr gklntkshar keqlllelwr eylmlvitqr tqlrltllcs pgsasnessv 361 cssnasdldm sllstpsslf qmagetksnp iiipdsqdds ilssdpf // LOCUS NP_014322 528 aa linear PLN 30-JUN-2025 DEFINITION Apj1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014322 VERSION NP_014322.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182915.1 REFERENCE 1 (residues 1 to 528) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 528) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 528) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 528) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 528) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10468. Method: conceptual translation. FEATURES Location/Qualifiers source 1..528 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..528 /product="Apj1p" /calculated_mol_wt="58758" Region 4..446 /region_name="PTZ00037" /note="DnaJ_C chaperone protein; Provisional" /db_xref="CDD:240236" CDS 1..528 /gene="APJ1" /locus_tag="YNL077W" /coded_by="NM_001182915.1:1..1587" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:23329686]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:direct assay:GO:0042405 nuclear inclusion body [PMID:32492414]" /experiment="EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:23329686]" /experiment="EXISTENCE:mutant phenotype:GO:0043335 protein unfolding [PMID:32492414]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:11923285]" /note="Hsp40 chaperone with a role in SUMO-mediated protein degradation; works in concert with Hsp70 and Hsp110 (Sse1p) to promote disaggregation of intranuclear protein inclusions; competes with Hsp104 in disaggregation, supporting turnover instead of refolding; member of DnaJ-like family, conserved across eukaryotes; overexpression interferes with propagation of the [Psi+] prion; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:855647" /db_xref="SGD:S000005021" ORIGIN 1 mqqntslyds lnvtaaasts eikkayrnaa lkyhpdknnh teeskrkfqe icqayeilkd 61 nrlralydqy gttdevliqe qqaqaqrqqa gpfssssnfd teamsfpdls pgdlfaqffn 121 ssatpssngs kssfnfsfnn sstpsfsfvn gsgvnnlyss sakynsnded hhldrgpdik 181 hnlkctlkel ymgktaklgl nrtricsvcd ghgglkkctc ktckgqgiqt qtrrmgplvq 241 swsqtcadcg gagvfvknkd icqqcqglgf ikerkilqvt vqpgschnql ivltgegdev 301 istkggghek vipgdvviti lrlkdpnfqv inysnlickk ckidfmtslc ggvvyieghp 361 sgklikldii pgeilkpgcf ktvedmgmpk fingvrsgfg hlyvkfdvty perlepenak 421 kiqnilandk yikaerstme tadsdcycdl eksydsveeh vlssfeapnl nneviedddl 481 gdlinerdsr krnnrrfdes ninnnnetkr nkysspvsgf ydhdingy // LOCUS NP_014323 584 aa linear PLN 30-JUN-2025 DEFINITION Mks1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014323 VERSION NP_014323.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182914.1 REFERENCE 1 (residues 1 to 584) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 584) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 584) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 584) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10469. Method: conceptual translation. FEATURES Location/Qualifiers source 1..584 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..584 /product="Mks1p" /calculated_mol_wt="65512" Region 37..64 /region_name="DUF1752" /note="Fungal protein of unknown function (DUF1752); pfam08550" /db_xref="CDD:430068" CDS 1..584 /gene="MKS1" /locus_tag="YNL076W" /gene_synonym="LYS80" /coded_by="NM_001182914.1:1..1755" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10511541]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11882290]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11882290]" /experiment="EXISTENCE:mutant phenotype:GO:0006808 regulation of nitrogen utilization [PMID:10511541]" /experiment="EXISTENCE:mutant phenotype:GO:2000220 regulation of pseudohyphal growth [PMID:22043304]" /experiment="EXISTENCE:physical interaction:GO:0031930 mitochondria-nucleus signaling pathway [PMID:14536080]" /note="Pleiotropic negative transcriptional regulator; involved in Ras-cAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling" /db_xref="GeneID:855648" /db_xref="SGD:S000005020" ORIGIN 1 msreafdvpn igtnkflkvt pnlftperln lfddvelylt likaskcveq gerlhniswr 61 ilnkavlkeh ninrskkrdg vkniyyvlnp nnkqpikpkq aavkqpplqk anlppttakq 121 nvltrpmtsp aiaqgahdrs ldnpnstnnd vkndvapnrq fsksttsglf snfadkyqkm 181 knvnhvanke epqtiitgfd tstvitkkpl qsrrsrspfq higdmnmnci dnetskstsp 241 tlenmgsrks sfpqkeslfg rprsykndqn gqlslsktss rkgknkiffs sededsdwds 301 vsndsefyad eddeeyddyn eeeadqyyrr qwdkllfakn qqnldstkss vssantinsn 361 tshdpvrksl lsglflsean snsnnhntah seyaskhvsp tpqsshsnig pqpqqnppsa 421 ngikqqkpsl ktsnvtalas lsppqpsnne rlsmdiqkdf ktdnesnhly esnapltaqt 481 ilptalsthm flpnnihqqr maiatgsntr hrfsrrqsmd ipsknrntgf lktrmeisee 541 ekmvrtisrl dntsiansng ngnddtsnqr tealgrktsn ggri // LOCUS NP_014324 290 aa linear PLN 30-JUN-2025 DEFINITION snoRNA-binding rRNA-processing protein IMP4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014324 VERSION NP_014324.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182913.3 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10470. On Jul 30, 2012 this sequence version replaced NP_014324.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..290 /product="snoRNA-binding rRNA-processing protein IMP4" /calculated_mol_wt="33351" Region 89..256 /region_name="Brix" /note="The Brix domain is found in a number of eukaryotic proteins; smart00879" /db_xref="CDD:214879" CDS 1..290 /gene="IMP4" /locus_tag="YNL075W" /coded_by="NM_001182913.3:1..873" /experiment="EXISTENCE:direct assay:GO:0006364 rRNA processing [PMID:23980203]" /experiment="EXISTENCE:direct assay:GO:0030515 snoRNA binding [PMID:15489263]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309|PMID:12242301]" /experiment="EXISTENCE:direct assay:GO:0034457 Mpp10 complex [PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:11864606]" /experiment="EXISTENCE:direct assay:GO:0042274 ribosomal small subunit biogenesis [PMID:23980203]" /experiment="EXISTENCE:direct assay:GO:0043047 single-stranded telomeric DNA binding [PMID:17803460]" /experiment="EXISTENCE:direct assay:GO:0140691 RNA folding chaperone [PMID:15489263]" /note="Subunit of the MPP10 chaperone complex and the small subunit (SSU) processome; contains both U3 snoRNA and rRNA primary transcript binding activity, as well as RNA chaperone activity; SSU processome is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs" /db_xref="GeneID:855649" /db_xref="SGD:S000005019" ORIGIN 1 mlrrqarerr eylyrkaqel qdsqlqqkrq iikqalaqgk plpkelaede slqkdfrydq 61 slkeseeadd lqvddeyaat sgimdpriiv ttsrdpstrl sqfakeikll fpnavrlnrg 121 nyvmpnlvda ckksgttdlv vlhehrgvpt sltishfphg ptaqfslhnv vmrhdiinag 181 nqsevnphli fdnfttalgk rvvcilkhlf nagpkkdser vitfanrgdf isvrqhvyvr 241 tregveiaev gprfemrlfe lrlgtlenkd advewqlrrf irtankkdyl // LOCUS NP_014325 452 aa linear PLN 30-JUN-2025 DEFINITION Mlf3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014325 VERSION NP_014325.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182912.3 REFERENCE 1 (residues 1 to 452) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 452) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 452) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 452) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10471. On Jul 30, 2012 this sequence version replaced NP_014325.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..452 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..452 /product="Mlf3p" /calculated_mol_wt="49079" CDS 1..452 /gene="MLF3" /locus_tag="YNL074C" /gene_synonym="YMK1" /coded_by="NM_001182912.3:1..1359" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:16816427]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:16816427]" /experiment="EXISTENCE:genetic interaction:GO:0034605 cellular response to heat [PMID:16816427]" /note="Serine-rich hypothetical protein; predicted to be palmitoylated; overproduction suppresses growth inhibition caused by exposure to immunosuppressant leflunomide; MLF3 has a paralog, VHS2, that arose from the whole genome duplication" /db_xref="GeneID:855650" /db_xref="SGD:S000005018" ORIGIN 1 mcvyksnsnn snpsfifert vqeassndlf lqppvsasnt shssrsnsfy nlqtispipi 61 sgsevrtpsl rknsnnvssp ldnviptsrs asnsttssla hqeyilnpic nmqnhhhrrr 121 tlensvapal dascsivnde ntdlsdvdmv ysrrpssavs lnmallartn satlpssess 181 paspdlklsr shshsaatrp tlnninntgm ttttsngepn srilrfysyv dmlndeklaq 241 anntptsrpp mksqayscpf ilkrsppqay ssssatttfs npfikttelp atspyvspqq 301 sarqysnnan nnakspknrs ssilfqrqsi lsnvdpvanm hknpkfqies sdseeedltm 361 dmldpsfpls sslrssanla snpelatqtp lstsssytai gkpmplstdp syvsssntls 421 sehelrvekv sevlkkkvsn ggfstefnsc dt // LOCUS NP_014326 576 aa linear PLN 30-JUN-2025 DEFINITION lysine--tRNA ligase MSK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014326 VERSION NP_014326.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182911.1 REFERENCE 1 (residues 1 to 576) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 576) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 576) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 576) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10472. Method: conceptual translation. FEATURES Location/Qualifiers source 1..576 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..576 /product="lysine--tRNA ligase MSK1" /EC_number="6.1.1.6" /calculated_mol_wt="65997" Region 41..573 /region_name="class_II_aaRS-like_core" /note="Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; cl00268" /db_xref="CDD:444800" Site 246..250 /site_type="other" /note="motif 1" /db_xref="CDD:238398" Site order(247..248,250,288..289,304,306,337) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238398" Site order(281,283,305,317,319,321..323,487..488,492,543..544, 546..547,550) /site_type="active" /db_xref="CDD:238398" Site 304..306 /site_type="other" /note="motif 2" /db_xref="CDD:238398" Site order(547,550) /site_type="other" /note="motif 3" /db_xref="CDD:238398" CDS 1..576 /gene="MSK1" /locus_tag="YNL073W" /coded_by="NM_001182911.1:1..1731" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:2016746]" /experiment="EXISTENCE:direct assay:GO:0008033 tRNA processing [PMID:17560369]" /experiment="EXISTENCE:mutant phenotype:GO:0004824 lysine-tRNA ligase activity [PMID:2016746]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:17560369]" /experiment="EXISTENCE:mutant phenotype:GO:0070154 mitochondrial lysyl-tRNA aminoacylation [PMID:2016746]" /note="Mitochondrial lysine-tRNA synthetase; required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys)" /db_xref="GeneID:855651" /db_xref="SGD:S000005017" ORIGIN 1 mnvllkrrsl tfaprwlwck crssrsrpys lahavdtskm eatrrngqiv kdlgryypsm 61 sesalhdlcq eykevtiadf nerflgnpat lhhednpnll lsingriksi rfsgqkivfi 121 dlyngssglk ndtqlqlivn ynkiggssed kanfseymnf lkkgdyikal gypgfsqsrv 181 kmlslicnkl pivlsvsqlp lpsrlndetk iksnrvvdyq lngtqtllvr ariikllrkf 241 lddrnfveve tpilssksng amakpfitss kdfdhlelri apelwlkrli isglqkvyei 301 gkvfrnegid sthnaefstl efyetymsmd divtrtedlf kflitnlqkf fqdtrlpvpk 361 tfselhlals ennwkfrkve flptlnkelg idlmnsgldi nkpsellkal pkdiakkyfp 421 sadntgqlss lqilnklsdv fleqrhcqst lptviyhqpa ilsplaktdp qnkqvtkrfe 481 vfikgkeyin ayeeencpql qlqkflqqkq ineltgnkte tlspvidyqy vetmkygmpp 541 vggfglgidr lcmlfcdkkr ieevlpfgcv ddvnrq // LOCUS NP_014327 307 aa linear PLN 30-JUN-2025 DEFINITION ribonuclease H2 catalytic subunit RNH201 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014327 VERSION NP_014327.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182910.1 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10473. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..307 /product="ribonuclease H2 catalytic subunit RNH201" /EC_number="3.1.26.4" /calculated_mol_wt="34744" Region 36..260 /region_name="RNase_HII_eukaryota_like" /note="Eukaryotic RNase HII; cd07181" /db_xref="CDD:260002" Site order(39..44,76,126..128,155..157,181,183,197,222,248..250) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260002" Site order(110,113..114,234..237,239,246,255,259..260) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:260002" CDS 1..307 /gene="RNH201" /locus_tag="YNL072W" /gene_synonym="RNH35" /coded_by="NM_001182910.1:1..924" /experiment="EXISTENCE:direct assay:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11029655]" /experiment="EXISTENCE:direct assay:GO:0032299 ribonuclease H2 complex [PMID:14734815]" /experiment="EXISTENCE:direct assay:GO:0043137 DNA replication, removal of RNA primer [PMID:10567561]" /experiment="EXISTENCE:genetic interaction:GO:0043137 DNA replication, removal of RNA primer [PMID:10567561]" /experiment="EXISTENCE:mutant phenotype:GO:0004523 RNA-DNA hybrid ribonuclease activity [PMID:14734815]" /note="Ribonuclease H2 catalytic subunit; removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; role in ribonucleotide excision repair; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome" /db_xref="GeneID:855652" /db_xref="SGD:S000005016" ORIGIN 1 mvpptveasl espytksyfs pvpsalleqn dspiimgide agrgpvlgpm vyavaystqk 61 yqdetiipny efddskkltd pirrmlfski yqdneeltqi gyattcitpl disrgmskfp 121 ptrnynlneq ahdvtmalid gvikqnvkls hvyvdtvgpp asyqkkleqr fpgvkftvak 181 kadslycmvs vasvvakvtr dilveslkrd pdeilgsgyp sdpktvawlk rnqtslmgwp 241 anmvrfswqt cqtllddask nsipikweeq ymdsrknaaq ktkqlqlqmv akpvrrkrlr 301 tldnwyr // LOCUS NP_014328 482 aa linear PLN 30-JUN-2025 DEFINITION dihydrolipoyllysine-residue acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014328 VERSION NP_014328.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182909.3 REFERENCE 1 (residues 1 to 482) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 482) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 482) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 482) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10474. On Jul 30, 2012 this sequence version replaced NP_014328.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..482 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..482 /product="dihydrolipoyllysine-residue acetyltransferase" /EC_number="2.3.1.12" /calculated_mol_wt="51687" Region 36..482 /region_name="PDHac_trf_mito" /note="pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; TIGR01349" /db_xref="CDD:273567" CDS 1..482 /gene="LAT1" /locus_tag="YNL071W" /gene_synonym="ODP2; PDA2" /coded_by="NM_001182909.3:1..1449" /experiment="EXISTENCE:direct assay:GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity [PMID:2271545]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11914276|PMID:14562095|PMID:14576278|PMID:16823961|P MID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006086 pyruvate decarboxylation to acetyl-CoA [PMID:7947791]" /experiment="EXISTENCE:direct assay:GO:0045254 pyruvate dehydrogenase complex [PMID:2007123|PMID:9038189]" /note="Dihydrolipoamide acetyltransferase component (E2) of the PDC; the pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA; metabolic longevity factor required for calorie restriction-mediated life span extension" /db_xref="GeneID:855653" /db_xref="SGD:S000005015" ORIGIN 1 msafvrvvpr isrssvltrs lrlqlrcyas ypehtiigmp alsptmtqgn laawtkkegd 61 qlspgeviae ietdkaqmdf efqedgylak ilvpegtkdi pvnkpiavyv edkadvpafk 121 dfkledsgsd sktstkaqpa epqaekkqea paeetktsap eakksdvaap qgrifaspla 181 ktialekgis lkdvhgtgpr gritkadies yleksskqss qtsgaaaatp aaatssttag 241 sapspsstas yedvpistmr siigerllqs tqgipsyivs skisiskllk lrqslnatan 301 dkyklsindl lvkaitvaak rvpdanaywl pnenvirkfk nvdvsvavat ptglltpivk 361 nceakglsqi sneikelvkr arinklapee fqggticisn mgmnnavnmf tsiinppqst 421 ilaiatverv avedaaaeng fsfdnqvtit gtfdhrtidg akgaefmkel ktvienplem 481 ll // LOCUS NP_014329 60 aa linear PLN 30-JUN-2025 DEFINITION Tom7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014329 VERSION NP_014329.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182908.1 REFERENCE 1 (residues 1 to 60) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 60) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 60) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 60) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10475. Method: conceptual translation. FEATURES Location/Qualifiers source 1..60 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..60 /product="Tom7p" /calculated_mol_wt="6739" Region 14..54 /region_name="Tom7" /note="TOM7 family; pfam08038" /db_xref="CDD:462344" CDS 1..60 /gene="TOM7" /locus_tag="YNL070W" /gene_synonym="MOM7; YOK22" /coded_by="NM_001182908.1:1..183" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667]" /experiment="EXISTENCE:mutant phenotype:GO:0005742 mitochondrial outer membrane translocase complex [PMID:8641278]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:8641278]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:8641278]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:8641278]" /note="Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex" /db_xref="GeneID:855654" /db_xref="SGD:S000005014" ORIGIN 1 msflpsfils deskeriski ltlthnvahy gwipfvlylg wahtsnrpnf lnllsplpsv // LOCUS NP_014330 198 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL13 RPL16B [Saccharomyces cerevisiae S288C]. ACCESSION NP_014330 VERSION NP_014330.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182907.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10476. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..198 /product="60S ribosomal protein uL13 RPL16B" /calculated_mol_wt="22118" Region 1..198 /region_name="PTZ00068" /note="60S ribosomal protein L13a; Provisional" /db_xref="CDD:240253" Site order(14,16..17,20,23,27,43,45,73..74,80..82,84..86,88, 90..91,93,95,99,102..103) /site_type="other" /note="23S rRNA interface [nucleotide binding]" /db_xref="CDD:238230" Site 74 /site_type="other" /note="L3 interface [polypeptide binding]" /db_xref="CDD:238230" CDS 1..198 /gene="RPL16B" /locus_tag="YNL069C" /gene_synonym="RP23" /coded_by="NM_001182907.1:1..597" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:27374275]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:27374275]" /note="Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication" /db_xref="GeneID:855655" /db_xref="SGD:S000005013" ORIGIN 1 msqpvvvida kdhllgrlas tiakqvlngq kivvvraeal nisgeffrnk lkyhdflrka 61 tafnktrgpf hfrapsrily kairgmvshk targkaaler lkifegippp ydkkkrvvvp 121 qalrvlrlkp grkyttlgkl stsvgwkyed vvakledkrk vrsaeyyakk raftkkvssa 181 saaasesdva kqlasfgy // LOCUS NP_014331 862 aa linear PLN 30-JUN-2025 DEFINITION forkhead family transcription factor FKH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014331 VERSION NP_014331.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182906.3 REFERENCE 1 (residues 1 to 862) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 862) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 862) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 862) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 862) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10477. On Jul 30, 2012 this sequence version replaced NP_014331.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..862 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..862 /product="forkhead family transcription factor FKH2" /calculated_mol_wt="94244" Region 1..610 /region_name="COG5025" /note="Transcription factor of the Forkhead/HNF3 family [Transcription]" /db_xref="CDD:227358" CDS 1..862 /gene="FKH2" /locus_tag="YNL068C" /coded_by="NM_001182906.3:1..2589" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:24504085]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:22265405|PMID:24504085]" /experiment="EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:10959837|PMID:15509804]" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:10899128]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20847055|PMID:22932476|PMID:10899128]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:24504085]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:10959837|PMID:15509804|PMID:10899128|PMID:12711672]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:17898805]" /experiment="EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:11562353|PMID:15509804|PMID:10959837|PMID:10894548|P MID:10894549|PMID:10747051]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17898805|PMID:10894549]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:17283050]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12702877]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11562353|PMID:10959837|PMID:15509804|PMID:10747051|P MID:10894548]" /experiment="EXISTENCE:genetic interaction:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10747051]" /experiment="EXISTENCE:genetic interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:15509804|PMID:10959837]" /experiment="EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:10747051|PMID:10894548]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10899128|PMID:10959837]" /experiment="EXISTENCE:mutant phenotype:GO:0003712 transcription coregulator activity [PMID:15509804]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:17283050]" /experiment="EXISTENCE:mutant phenotype:GO:0032298 positive regulation of DNA-templated DNA replication initiation [PMID:22265405]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12702877]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10899128|PMID:10959837]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10747051]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12711672|PMID:15509804|PMID:10899128]" /experiment="EXISTENCE:mutant phenotype:GO:1903468 positive regulation of DNA replication initiation [PMID:26728715]" /experiment="EXISTENCE:mutant phenotype:GO:2000221 negative regulation of pseudohyphal growth [PMID:10894548]" /note="Forkhead family transcription factor; rate-limiting activator of replication origins; evolutionarily conserved regulator of lifespan; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; positively regulates transcriptional elongation; facilitates clustering, activation of early-firing replication origins; negative role in chromatin silencing at HML and HMR; major role in expression of G2/M phase genes; relocalizes to cytosol under hypoxia" /db_xref="GeneID:855656" /db_xref="SGD:S000005012" ORIGIN 1 msssnfnemn elnmtqtnyg stkytaqhhq gvinaiissl tapdqpttvs lqysndknma 61 teiqayakls gpnwtyyvkd levsigrntd plnsalqens dgvknsyrvn idlgpakvvs 121 rkhaiikynm niggwelhil grngakvnfq rthngpnnpp irlssgtlld iggtqmmfil 181 pdsdpvvapi ciehlmpnli nmfglegnnn pllrdiikqs nyakqrqlts nqqikgfkly 241 gsggnapfgs ganlgpseqg ifnnnnnskn kngyftsinp nytastttsn tinpqaaspq 301 gppntiiaan fvdsykssna ypqaldftsd lshdenrnvk pphsyatmit qailsspegv 361 isladiykyi ssnyayyrfa ksgwqnsirh nlslnkafek vprrpnepgk gmkwrisesy 421 qqeflnkwnt gkvgkirrgs svarqlqlhm akfnslpmem dyrlslnmaq ppkrqlqshn 481 vlepsnnnii egfvqhvpsk gnlpasqqsq ppvshqnqsq qpppqeqrqe iqftfadtqn 541 rnialarpik tpqlqapnsn anlnqnnmke ykeslhppai sisqmnrqsp nnalvsftna 601 canskiinni sdsadkstnn nggtkmnlpa istssldeng nlepttttss gnsnsvpqtg 661 tttsslaans lrlsqpydtl lrsptkafhi tameaytper gsanrarspl hsnsnntnnn 721 gannsnlqts gmenkqtglv ldsnvlksme snndnrrltp stsksqnvks spgvwnllqf 781 sstnntpaad sggnkrgfsi npdikakene natsekdsds nsndletkdi nssplknqgg 841 stanakelil dtdgakisii nn // LOCUS NP_878156 46 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL067W-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878156 VERSION NP_878156.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184639.3 REFERENCE 1 (residues 1 to 46) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 46) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 46) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 46) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 46) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10478. On Jul 30, 2012 this sequence version replaced NP_878156.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..46 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..46 /product="uncharacterized protein" /calculated_mol_wt="5184" CDS 1..46 /locus_tag="YNL067W-B" /gene_synonym="YNL067W-A" /coded_by="NM_001184639.3:1..141" /note="hypothetical protein" /db_xref="GeneID:1466514" /db_xref="SGD:S000028810" ORIGIN 1 mcklmwctgv vsktalltgn fffsssefff kathrkseny lngrqt // LOCUS NP_014332 191 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL6 RPL9B [Saccharomyces cerevisiae S288C]. ACCESSION NP_014332 VERSION NP_014332.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182905.1 REFERENCE 1 (residues 1 to 191) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 191) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 191) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 191) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 191) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10479. Method: conceptual translation. FEATURES Location/Qualifiers source 1..191 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..191 /product="60S ribosomal protein uL6 RPL9B" /calculated_mol_wt="21526" Region 1..190 /region_name="PTZ00027" /note="60S ribosomal protein L6; Provisional" /db_xref="CDD:240234" CDS 1..191 /gene="RPL9B" /locus_tag="YNL067W" /coded_by="NM_001182905.1:1..576" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L9B; homologous to mammalian ribosomal protein L9 and bacterial L6; RPL9B has a paralog, RPL9A, that arose from a single-locus duplication" /db_xref="GeneID:855658" /db_xref="SGD:S000005011" ORIGIN 1 mkyiqteqqi eipegvtvsi ksrivkvvgp rgtltknlkh idvtftkvnn qlikvavhng 61 drkhvaalrt vkslvdnmit gvtkgykykm ryvyahfpin vnivekdgak fievrnflgd 121 kkirnvpvrd gvtiefstnv kdeivlsgns vedvsqnaad lqqicrvrnk dirkfldgiy 181 vshkgfived m // LOCUS NP_014333 420 aa linear PLN 30-JUN-2025 DEFINITION putative glucosidase SUN4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014333 VERSION NP_014333.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182904.1 REFERENCE 1 (residues 1 to 420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 420) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10480. Method: conceptual translation. FEATURES Location/Qualifiers source 1..420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..420 /product="putative glucosidase SUN4" /calculated_mol_wt="43311" Region 165..406 /region_name="SUN" /note="Beta-glucosidase (SUN family); pfam03856" /db_xref="CDD:427547" CDS 1..420 /gene="SUN4" /locus_tag="YNL066W" /gene_synonym="SCW3" /coded_by="NM_001182904.1:1..1263" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:27229769]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11958935]" /note="Cell wall protein related to glucanases localized in birth scars; possibly involved in cell wall septation; member of the SUN family; SUN4 has a paralog, SIM1, that arose from the whole genome duplication" /db_xref="GeneID:855659" /db_xref="SGD:S000005010" ORIGIN 1 mklsattlta asligystiv salpyaadid tgctttahgs hqhkravavt yvyetvtvdk 61 ngqtvtptst easstvastt tlisessvtk ssskvassse steqiattss saqttltsse 121 tstsessvpi stsgsastss aassatgsiy gdladfsgpy ekfedgtipc gqfpsgqgvi 181 piswldeggw sgventdtst ggsckegsyc syacqpgmsk tqwpsdqpsd grsiggllck 241 dgylyrsntd tdylcewgvd aayvvselsn dvaicrtdyp gtenmvipty vqagdslplt 301 vvdqdtyytw qglktsaqyy vnnagisved acvwgssssg vgnwaplnfg agssdgvayl 361 slipnpnngn alnfnvkiva addsstvnge ciyengsfsg gsdgctvsvt agkakfvlyn // LOCUS NP_014334 586 aa linear PLN 30-JUN-2025 DEFINITION Aqr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014334 VERSION NP_014334.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182903.3 REFERENCE 1 (residues 1 to 586) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 586) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 586) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 586) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10481. On Jul 30, 2012 this sequence version replaced NP_014334.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..586 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..586 /product="Aqr1p" /calculated_mol_wt="65165" Region 103..553 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(113..114,117..118,121,153,203..204,206..208,211,231, 234..235,238,348,351..352,355..357,360,385,389,473..474, 478,482,497,500..501,504..505,508) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..586 /gene="AQR1" /locus_tag="YNL065W" /coded_by="NM_001182903.3:1..1761" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:34887841|PMID:11922628|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0032973 amino acid export across plasma membrane [PMID:15590823]" /experiment="EXISTENCE:mutant phenotype:GO:0008028 monocarboxylic acid transmembrane transporter activity [PMID:11922628]" /experiment="EXISTENCE:mutant phenotype:GO:0015565 threonine efflux transmembrane transporter activity [PMID:34887841]" /experiment="EXISTENCE:mutant phenotype:GO:0015718 monocarboxylic acid transport [PMID:11922628]" /experiment="EXISTENCE:mutant phenotype:GO:0032973 amino acid export across plasma membrane [PMID:34887841|PMID:15590823]" /experiment="EXISTENCE:mutant phenotype:GO:0042910 xenobiotic transmembrane transporter activity [PMID:11922628]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:11922628]" /note="Plasma membrane transporter of the major facilitator superfamily; involved in the excretion of excess amino acids; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; relocalizes from plasma membrane to cytoplasm upon DNA replication stress; AQR1 has a paralog, QDR1, that arose from the whole genome duplication" /db_xref="GeneID:855660" /db_xref="SGD:S000005009" ORIGIN 1 msrsnsiyte diemypthne qhltreytkp dgqtksekln fegayinshg tlsktttrei 61 egdldsetss hssddkvdpt qqitaetkap ytllsygqkw gmvailtmcg fwsslgspiy 121 ypalrqlekq fnvdenmvnv tvvvyllfqg isptvsggla dcfgrrpiil agmliyvias 181 iglacapsyg viiflrciqs igisptiais sgvvgdftlk hergtfvgat sgfvllgqcf 241 gsligavlta rwdwraifwf ltigcgscfl iaflilpetk rtiagnlsik pkrfinrapi 301 fllgpvrrrf kydnpdyetl dptipkldls sagkilvlpe iilslfpsgl lfamwtlmls 361 sissglsvap ynyhlviigv cylpggiggl mgsfftgrii dmyfkrkikk feqdkangli 421 pqdaeinmfk vrlvcllpqn flavvayllf gwsidkgwri esilitsfvc sycamstlst 481 sttllvdlyp tksstasscf nfvrcslsti fmgcfakmka amtvggtftf lcalvfffnf 541 lmfipmkygm kwredrllkq qrqswlntla vkakkgtkrd qndnhn // LOCUS NP_014335 409 aa linear PLN 30-JUN-2025 DEFINITION type I HSP40 co-chaperone YDJ1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014335 VERSION NP_014335.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182902.1 REFERENCE 1 (residues 1 to 409) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 409) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 409) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 409) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10482. Method: conceptual translation. FEATURES Location/Qualifiers source 1..409 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..409 /product="type I HSP40 co-chaperone YDJ1" /calculated_mol_wt="44540" Region 2..409 /region_name="PTZ00037" /note="DnaJ_C chaperone protein; Provisional" /db_xref="CDD:240236" CDS 1..409 /gene="YDJ1" /locus_tag="YNL064C" /gene_synonym="HSP40; MAB3; MAS5" /coded_by="NM_001182902.1:1..1230" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:15342786|PMID:1400408]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:1869583|PMID:26928762|PMID:8144572]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9674429]" /experiment="EXISTENCE:direct assay:GO:0048471 perinuclear region of cytoplasm [PMID:1869583]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:9774392]" /experiment="EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]" /experiment="EXISTENCE:mutant phenotype:GO:0006458 'de novo' protein folding [PMID:10567418]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25344756]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:1729605]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:25853343]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:25344756]" /experiment="EXISTENCE:mutant phenotype:GO:0035719 tRNA import into nucleus [PMID:25853343]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:15252059|PMID:15342786]" /experiment="EXISTENCE:mutant phenotype:GO:0045047 protein targeting to ER [PMID:1473150]" /note="Type I HSP40 co-chaperone; regulates HSP90 and HSP70 functions; acts as an adaptor that helps Rsp5p recognize and ubiquitinate misfolded, cytosolic proteins after heat shock; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; forms cytotoxic amyloidogenic-like structures in vitro; DnaJ family member; chimeric protein in which the human p58IPK J domain replaces the yeast Ydj1p J domain can complement yeast ydj1 mutant" /db_xref="GeneID:855661" /db_xref="SGD:S000005008" ORIGIN 1 mvketkfydi lgvpvtatdv eikkayrkca lkyhpdknps eeaaekfkea saayeilsdp 61 ekrdiydqfg edglsgagga ggfpgggfgf gddifsqffg aggaqrprgp qrgkdikhei 121 sasleelykg rtaklalnkq ilckecegrg gkkgavkkct scngqgikfv trqmgpmiqr 181 fqtecdvchg tgdiidpkdr ckscngkkve nerkilevhv epgmkdgqri vfkgeadqap 241 dvipgdvvfi vserphksfk rdgddlvyea eidlltaiag gefalehvsg dwlkvgivpg 301 eviapgmrkv iegkgmpipk yggygnliik ftikfpenhf tseenlkkle eilpprivpa 361 ipkkatvdec vladfdpaky nrtrasrgga nydsdeeeqg gegvqcasq // LOCUS NP_014336 314 aa linear PLN 30-JUN-2025 DEFINITION S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014336 VERSION NP_014336.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182901.1 REFERENCE 1 (residues 1 to 314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 314) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10483. Method: conceptual translation. FEATURES Location/Qualifiers source 1..314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..314 /product="S-adenosylmethionine-dependent methyltransferase" /EC_number="2.1.1.297" /calculated_mol_wt="35740" Region 1..283 /region_name="hemK_fam" /note="HemK family putative methylases; TIGR00536" /db_xref="CDD:273125" CDS 1..314 /gene="MTQ1" /locus_tag="YNL063W" /coded_by="NM_001182901.1:1..945" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:16321977]" /experiment="EXISTENCE:genetic interaction:GO:0006451 translational readthrough [PMID:16321977]" /experiment="EXISTENCE:mutant phenotype:GO:0008757 S-adenosylmethionine-dependent methyltransferase activity [PMID:16321977]" /note="S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene" /db_xref="GeneID:855662" /db_xref="SGD:S000005007" ORIGIN 1 mpristslir kasrirpglh lllpecrtle qakleykwlt eelppdksir waclqrykhv 61 plqyilrsqp fgaldivckp gvliprwete ewvmaiiral nnsmlsrhti plhicdtftg 121 tgcialalsh gianctftai dvstraiklv kenmlknkvs ggklvqhnil sskasdeyps 181 hidiltgnpp yirkrdfnrd vktsvklfep rlalvgelec yinlvnywlp ktdsffyeig 241 dveqfnyver rikedsylsr iwsiglkyds ngkarvvygf katpkgrilh qifasfgtir 301 hlatalsghk ancn // LOCUS NP_014337 478 aa linear PLN 30-JUN-2025 DEFINITION tRNA 1-methyladenosine methyltransferase subunit GCD10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014337 VERSION NP_014337.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182900.3 REFERENCE 1 (residues 1 to 478) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 478) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 478) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10484. On Jul 30, 2012 this sequence version replaced NP_014337.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..478 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..478 /product="tRNA 1-methyladenosine methyltransferase subunit GCD10" /calculated_mol_wt="54258" Region 6..329 /region_name="Gcd10p" /note="Gcd10p family; pfam04189" /db_xref="CDD:461216" CDS 1..478 /gene="GCD10" /locus_tag="YNL062C" /gene_synonym="TRM6" /coded_by="NM_001182900.3:1..1437" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9851972]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:10779558]" /experiment="EXISTENCE:direct assay:GO:0031515 tRNA (m1A) methyltransferase complex [PMID:10779558]" /experiment="EXISTENCE:direct assay:GO:0160107 tRNA (adenine(58)-N1)-methyltransferase activity [PMID:10779558]" /experiment="EXISTENCE:physical interaction:GO:0031515 tRNA (m1A) methyltransferase complex [PMID:10779558]" /note="Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p; required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression" /db_xref="GeneID:855663" /db_xref="SGD:S000005006" ORIGIN 1 mnalttidfn qhvivrlpsk nykivelkpn tsvslgkfga fevndiigyp fgltfeiyyd 61 geevssdenr dskpknkipi gkvrllsqei kdvnndkddg qsepplsike ksvslelssi 121 dssatnqnlv nmgskaqelt veeiekmkqe slsskeiidk iikshksfhn ktvysqekyv 181 nrkkqkfaky ftveylsssn llqflidkgd iqrvldmsqe smgmllnlan iqsegnylcm 241 detggllvyf llermfggdn eskskgkviv ihenehanld llkfanysek fikehvhtis 301 lldffepptl qeiqsrftpl pkeearalkg gkknsyyrkl rwyntqwqil eltgeflydg 361 lvmattlhlp tlvpklaeki hgsrpivcyg qfketllela htlysdlrfl apsiletrcr 421 pyqsirgklh plmtmkgggg ylmwchrvip apepvsenat aadsseklae hgakkqki // LOCUS NP_014338 618 aa linear PLN 30-JUN-2025 DEFINITION rRNA (cytosine-C5-)-methyltransferase NOP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014338 VERSION NP_014338.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182899.3 REFERENCE 1 (residues 1 to 618) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 618) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 618) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 618) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10485. On Jul 30, 2012 this sequence version replaced NP_014338.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..618 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..618 /product="rRNA (cytosine-C5-)-methyltransferase NOP2" /EC_number="2.1.1.310" /calculated_mol_wt="69681" Region 273..548 /region_name="nop2p" /note="NOL1/NOP2/sun family putative RNA methylase; TIGR00446" /db_xref="CDD:188051" CDS 1..618 /gene="NOP2" /locus_tag="YNL061W" /gene_synonym="YNA1" /coded_by="NM_001182899.3:1..1857" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:26196125|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:22735702|PMID:17443350]" /experiment="EXISTENCE:direct assay:GO:0070475 rRNA base methylation [PMID:23913415]" /experiment="EXISTENCE:genetic interaction:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:genetic interaction:GO:0070475 rRNA base methylation [PMID:23913415]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8972218]" /experiment="EXISTENCE:mutant phenotype:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:8972218]" /experiment="EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:23913415]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]" /note="rRNA m5C methyltransferase; methylates cytosine at position 2870 of 25S rRNA; has an essential function independent of rRNA methylation; contains seven beta-strand methyltransferase motif; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles; rRNA methylation defect and lethality are functionally complemented by human NOP2, a gene upregulated in cancer" /db_xref="GeneID:855664" /db_xref="SGD:S000005005" ORIGIN 1 mgsrrhknkq aapptleefq arkekkanrk lekgkrpstt qgdevsdrkk kkskpfkksr 61 keeeevveed kdlpevdlee lskarkslfd deedddeagl vdeelkdefd leqeydyded 121 edndahpifs ddddeadlee lnaqnmeals kkldeeeaee aeeaemelve aenmqpradi 181 lpteeqeemm aqetpnltst rtrmieivkv lenfktlgae grsrgeyvdr llkdiceyfg 241 ytpflaeklf nlfspaeame ffeaneiarp itirtntlkt rrrdlaqtlv nrgvnlqpig 301 swtkvglqif dsqvpigatp eylaghyilq aassflpvia ldpheneril dmaaapggkt 361 tyisammknt gcvfandank srtksliani hrlgctntiv cnydarefpk viggfdrill 421 dapcsgtgvi gkdqsvkvsr tekdfiqiph lqkqlllsai dsvdcnskhg gvivystcsv 481 aveedeavid yalrkrpnvk lvdtglaigk eaftsyrgkk fhpsvklarr yyphtynvdg 541 ffvakfqkig pssfddnqas akeketaark ealeegiihs dfatfedeed dkyieksvkn 601 nllkkgvnpk akrpsnek // LOCUS NP_014339 755 aa linear PLN 30-JUN-2025 DEFINITION actin-related protein ARP5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014339 VERSION NP_014339.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182898.1 REFERENCE 1 (residues 1 to 755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 755) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10486. Method: conceptual translation. FEATURES Location/Qualifiers source 1..755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..755 /product="actin-related protein ARP5" /calculated_mol_wt="87430" Region 39..>281 /region_name="ASKHA_NBD_Arp5" /note="nucleotide-binding domain (NBD) of actin-related protein5 (Arp5) and similar proteins; cd10211" /db_xref="CDD:466817" Region <289..>431 /region_name="Nop14" /note="Nop14-like family; pfam04147" /db_xref="CDD:461196" Region <536..748 /region_name="ASKHA_ATPase-like" /note="ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; cl49607" /db_xref="CDD:483947" CDS 1..755 /gene="ARP5" /locus_tag="YNL059C" /coded_by="NM_001182898.1:1..2268" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10923024|PMID:11011149]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12887900]" /experiment="EXISTENCE:direct assay:GO:0030234 enzyme regulator activity [PMID:26306040]" /experiment="EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:12887900|PMID:15525518]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:12887900]" /experiment="EXISTENCE:mutant phenotype:GO:0031011 Ino80 complex [PMID:12887900]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:15525518]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; promotes nucleosome shifts in the 3 prime direction" /db_xref="GeneID:855665" /db_xref="SGD:S000005004" ORIGIN 1 mssrdasltp lkavviddpp lrqtpepfde qsaynpqspi aidfgssklr agfvnhatpt 61 hifpnaltkf rdrklnknft fvgndtlldq avrsqsrspf dgpfvtnwnl teeildytfh 121 hlgvvpdngi pnpillterl atvqsqrtnw yqilfetynv pgvtfgidsl fsfynynpsg 181 nktglviscg hedtnvipvv dgagiltdak rinwgghqav dylndlmalk ypyfptkmsy 241 lqyetmykdy cyvsrnyded iekiltlenl dtndvvveap ftevlqpqkt eeelriqaek 301 rketgkrlqe qarlkrmekl vqkqeefeyf skvrdqlide pkkkvlsvlq nagfdderdf 361 kkylhsleqs lkkaqmveae ddshldemne dktaqkfdll diadedlned qikekrkqrf 421 lkasqdarqk akeekervak eeeekklkeq qwretdlngw ikdkrlklnk likrrkeklk 481 lrdemkdrks qvsqnrmknl aslaednvkq gakrnrhqat idndpndtfg andedwliyt 541 ditqnpeafe ealeyeykdi velerllleh dpnfteedtl eaqydwrnsi lhlflrgprp 601 hdseniheqh qmhlnverir vpevifqptm ggqdqagice lsetillkkf gsqpgklsqt 661 sidmvnnvli tggnakvpgl kerivkeftg flptgtnitv nmssdpslda wkgmaalarn 721 eeqyrktvis kkeyeeygpe yikehklgnt kyfed // LOCUS NP_014340 316 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL058C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014340 VERSION NP_014340.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182897.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10487. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..316 /product="uncharacterized protein" /calculated_mol_wt="34915" CDS 1..316 /locus_tag="YNL058C" /coded_by="NM_001182897.1:1..951" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to vacuole; not an essential gene; YNL058C has a paralog, PRM5, that arose from the whole genome duplication" /db_xref="GeneID:855667" /db_xref="SGD:S000005003" ORIGIN 1 mvkknfipsv slvrrdlptl vttttsstal skptssvvse tsskslpslt ssafstssga 61 tsssslivas itppstagnp filnaadkpn gtvyiavgav igaifisili wwlvssylsr 121 rftmtnsyan dsknlyrghh khssslqsnp fdindeksym qddwdsmsql essqyedaas 181 pfnpiqdpft dnrrslfisp tlqvsqyeks hsrhqskdtn ifiddpflyv gtyleeeeee 241 eeerklnlnr pqraasperk ekkinsmegy hkrnqsslgl ipvasatsnt sspkkahkrq 301 apsmflddvl ngreii // LOCUS NP_014342 197 aa linear PLN 30-JUN-2025 DEFINITION Oca2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014342 VERSION NP_014342.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182895.3 REFERENCE 1 (residues 1 to 197) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 197) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 197) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10488. On Jul 30, 2012 this sequence version replaced NP_014342.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..197 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..197 /product="Oca2p" /calculated_mol_wt="22341" Region 4..151 /region_name="PFA-DSP_Oca2" /note="atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 2; cd17661" /db_xref="CDD:350499" CDS 1..197 /gene="OCA2" /locus_tag="YNL056W" /coded_by="NM_001182895.3:1..594" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; similar to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene" /db_xref="GeneID:855668" /db_xref="SGD:S000005001" ORIGIN 1 mkyipplnfs pvvstdvsly rsgypmplny sfikhqlhlk tiiyigdkdr pleeyqsfle 61 sekikyyhif mdssrdegiq ermnqvlhlv ldvrnypilv hsnkgkhrvg vvvgiirkll 121 qgwstagicq eyglfsggmk dgvdlefitm fetnlkiprn vipgfakhcl ylneleaaeg 181 sddesgsesi ltakqpi // LOCUS NP_014343 283 aa linear PLN 30-JUN-2025 DEFINITION porin POR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014343 VERSION NP_014343.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182894.1 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10489. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..283 /product="porin POR1" /calculated_mol_wt="30297" Region 3..282 /region_name="Porin3_VDAC" /note="Voltage-dependent anion channel of the outer mitochondrial membrane; cd07306" /db_xref="CDD:132767" Site order(15,19,46,61,84,152,282) /site_type="active" /note="putative determinants of voltage gating [active]" /db_xref="CDD:132767" Site order(27,29,257,259,277) /site_type="other" /note="putative dimerization interface [polypeptide binding]" /db_xref="CDD:132767" CDS 1..283 /gene="POR1" /locus_tag="YNL055C" /gene_synonym="OMP2" /coded_by="NM_001182894.1:1..852" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:7499333|PMID:16689936|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0006811 monoatomic ion transport [PMID:9593723]" /experiment="EXISTENCE:direct assay:GO:0008308 voltage-gated monoatomic anion channel activity [PMID:9593723]" /experiment="EXISTENCE:direct assay:GO:0017128 phospholipid scramblase activity [PMID:38065946]" /experiment="EXISTENCE:direct assay:GO:0048039 ubiquinone binding [PMID:38906315|PMID:28051849]" /experiment="EXISTENCE:mutant phenotype:GO:0005741 mitochondrial outer membrane [PMID:38065946]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17822411]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11488609]" /experiment="EXISTENCE:mutant phenotype:GO:0042307 positive regulation of protein import into nucleus [PMID:29359182]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:38065946]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:18768136]" /experiment="EXISTENCE:mutant phenotype:GO:0051027 DNA transport [PMID:19056337]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /experiment="EXISTENCE:physical interaction:GO:0044289 mitochondrial inner-outer membrane contact site [PMID:37073556]" /note="Mitochondrial porin and phospholipid scramblase; voltage-dependent anion channel in the outer mitochondrial membrane required for maintenance of mitochondrial osmotic stability and membrane permeability; scramblase involved in mitochondrial transbilayer translocation of phospholipids; ubiquinone binding protein; couples glutathione pools of the intermembrane space and the cytosol; phosphorylated; protein abundance increases in response to DNA replication stress; orthologous to human VDAC1 and 2" /db_xref="GeneID:855669" /db_xref="SGD:S000005000" ORIGIN 1 msppvysdis rnindllnkd fyhatpaafd vqtttangik fslkakqpvk dgplstnvea 61 klndkqtglg ltqgwsntnn lqtklefanl tpglknelit sltpgvaksa vlnttftqpf 121 ftargafdlc lksptfvgdl tmahegivgg aefgydisag sisryamals yfakdyslga 181 tlnneqittv dffqnvnafl qvgakatmnc klpnsnvnie fatrylpdas sqvkakvsds 241 givtlaykql lrpgvtlgvg ssfdalklse pvhklgwsls fda // LOCUS NP_058180 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058180 VERSION NP_058180.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184413.3 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10490. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..440 /product="gag protein" /calculated_mol_wt="49101" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YNL054W-A" /coded_by="NM_001184413.3:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:855671" /db_xref="SGD:S000007384" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqtaqshsp qngpypqqcm mtqnqanpsd wsfygrpsmi pytpyqmspm 121 yfppgphsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 flnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_001268465 1749 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_001268465 VERSION NP_001268465.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001281536.2 REFERENCE 1 (residues 1 to 1749) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1749) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1749) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1749) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA64521. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1749 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1749 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198068" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1259..>1447 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1600..1736 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1604..1607,1641..1643,1646,1679,1706,1733) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1749 /locus_tag="YNL054W-B" /coded_by="join(NM_001281536.2:1..1305, NM_001281536.2:1307..5251)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="TyB Gag-Pol protein; proteolytically processed to make the Gag, reverse transcriptase (RT), protease (PR), and integrase (IN) proteins that are required for retrotransposition" /db_xref="GeneID:855672" /db_xref="SGD:S000007385" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqtaqshsp qngpypqqcm mtqnqanpsd wsfygrpsmi pytpyqmspm 121 yfppgphsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 flnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsd dlnfqsdiel hpeqprnvls kavsptdstp 961 psthtedskr vsktnirapr evdpnisksd ilpskkrsst pqisdiestg sggmhrldvp 1021 llapmsqsnt hesshtsksk dfrhsdsysd netnhtnvpi sstggtnnkt vpqtseqete 1081 kriihrspsi dtsssesnsl hhvvpiktsd tcpkentees iiadlplpdl ppepptklsd 1141 sfkelppins rqtnsslggi gdsnayttin skkrsledne teikvsrdtw ntknmrslep 1201 prskkrihli aavkavksik pirttlryde aitynkdike kekyieayhk evnqllkmkt 1261 wdtdkyydrk eidpkrvins mfifnrkrdg thkarfvarg diqhpdtyds gmqsntvhhy 1321 almtslslal dnnyyitqld issaylyadi keelyirppp hlgmndklir lkkslyglkq 1381 sganwyetik sylieqcdme evrgwscvfk nsqvticlfv ddmilfskdl nankkiittl 1441 kkqydtkiin lgesdneiqy dilgleikyq rskymklgme kslteklpkl nvhlnpkgkk 1501 lsapgqpgly idqdeleide deykekvhem qkliglasyv gykfrfdlly yintlaqhil 1561 fpsrqvldmt yeliqfmwdt rdkqliwhkn kptkpdnklv aisdasygnq pyyksqigni 1621 fllngkvigg kstkasltct stteaeihav seaipllnnl shlvqelnkk piikglltds 1681 rstisiikst neekfrnrff gtkamrlrde vsgnnlyvyy ietkkniadv mtkplpiktf 1741 klltnkwih // LOCUS NP_014344 1165 aa linear PLN 30-JUN-2025 DEFINITION Vac7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014344 VERSION NP_014344.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182893.3 REFERENCE 1 (residues 1 to 1165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1165) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10491. On Jul 30, 2012 this sequence version replaced NP_014344.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1165 /product="Vac7p" /calculated_mol_wt="128010" Region 424..>453 /region_name="Vac7" /note="Vacuolar segregation subunit 7; pfam12751" /db_xref="CDD:432760" Region <923..1001 /region_name="Vac7" /note="Vacuolar segregation subunit 7; pfam12751" /db_xref="CDD:432760" CDS 1..1165 /gene="VAC7" /locus_tag="YNL054W" /coded_by="NM_001182893.3:1..3498" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:9372916|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9372916]" /experiment="EXISTENCE:direct assay:GO:0070772 PAS complex [PMID:19037259]" /experiment="EXISTENCE:genetic interaction:GO:0008047 enzyme activator activity [PMID:11950935]" /experiment="EXISTENCE:genetic interaction:GO:0010513 positive regulation of phosphatidylinositol biosynthetic process [PMID:11950935]" /experiment="EXISTENCE:mutant phenotype:GO:1903778 protein localization to vacuolar membrane [PMID:17699591]" /experiment="EXISTENCE:physical interaction:GO:0070772 PAS complex [PMID:19037259]" /note="Integral vacuolar membrane protein; involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:855673" /db_xref="SGD:S000004999" ORIGIN 1 mteedrkltv etetveapva nnlllsnnsn vvapnpsips aststsplhr eivddsvata 61 nttsnvvqhn lptidnnlmd sdatshnqdh whsdinragt smstsdiptd lhlehigsvs 121 stnnnsnnal inhnplsshl snpssslrnk kssllvasnp afasdvelsk kkpavisnnm 181 ptsnialyqt arsanihgps stsaskafrk asafsnntap stsnnigsnt ppapllplps 241 lsqqnkpkii erptmhvtns reillgenll ddtkaknapa nstthdngpv andglripnh 301 snaddnennn kmkknknins gknernddts kicttstkta pstaplgstd ntqaltasvs 361 ssnadnhnnn kkktssnnng nnsnsasnkt nadiknsnad lsastsnnna inddshesns 421 ekptkadffa arlatavgen eisdseetfv yesaanstkn lifpdsssqq qqqqqqppkq 481 qqqqqnhgit skisapllnn nkkllsrlkn srhistgail nntiatistn pnlnsnvmqn 541 nnnlmsghnh ldelssikqe pphqlqqqqp pmdvqsvdsy tsdnpdsnvi akspdkrssl 601 vslskvsphl lsstssngnt iscpnvatns qelepnndis tkkslsnstl rhssanrnsn 661 ygdnkrplrt tvskifdsnp ngaplrrysg vpdhvnledy ieqphnyptm qnsvkkdefy 721 nsrnnkfphg lnfygdnnvi eeenngdssn vnrpqhtnlq hefipednes dendihsmfy 781 ynhkndletk plisdygede dvddydrpna tfnsyygsas nthelplhgr mpsrsnndyy 841 dfmvgnntgn nnqlneytpl rmkrgqrhls rtnnsimngs ihmngnddvt hsninnndiv 901 gysphnfysr kspfvkvknf lylafvissl lmtgfilgfl latnkelqdv dvvvmdnvis 961 ssdelifdit vsafnpgffs isvsqvdldi fakssylkcd sngdctvmeq erkilqittn 1021 lslveesann disggnietv llgtakklet plkfqggafn rnydvsvssv kllspgsrea 1081 khendddddd dgddgddenn tnerqykskp narddkeddt kkwkllikhd yelivrgsmk 1141 yevpffntqk staiqkdsmv hpgkk // LOCUS NP_014345 489 aa linear PLN 30-JUN-2025 DEFINITION tyrosine/serine/threonine protein phosphatase MSG5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014345 VERSION NP_014345.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182892.3 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10492. On Jul 30, 2012 this sequence version replaced NP_014345.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..489 /product="tyrosine/serine/threonine protein phosphatase MSG5" /EC_number="3.1.3.48" /calculated_mol_wt="54087" Region 230..373 /region_name="DSP_fungal_SDP1-like" /note="dual specificity phosphatase domain of fungal dual specificity protein phosphatase SDP1, MSG5, and similar proteins; cd14521" /db_xref="CDD:350371" CDS 1..489 /gene="MSG5" /locus_tag="YNL053W" /coded_by="NM_001182892.3:1..1470" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17963515|PMID:17952059]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17963515|PMID:17952059|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008138 protein tyrosine/serine/threonine phosphatase activity [PMID:8306972]" /experiment="EXISTENCE:direct assay:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:14703512]" /experiment="EXISTENCE:direct assay:GO:1903138 negative regulation of cell integrity MAPK cascade [PMID:8306972|PMID:14703512]" /experiment="EXISTENCE:genetic interaction:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:10625705|PMID:11923319]" /experiment="EXISTENCE:genetic interaction:GO:1903138 negative regulation of cell integrity MAPK cascade [PMID:10625705|PMID:11923319]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:14703512]" /experiment="EXISTENCE:mutant phenotype:GO:0071507 pheromone response MAPK cascade [PMID:8306972]" /experiment="EXISTENCE:mutant phenotype:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:10625705|PMID:14703512]" /experiment="EXISTENCE:mutant phenotype:GO:1903138 negative regulation of cell integrity MAPK cascade [PMID:14703512|PMID:10625705|PMID:8306972]" /note="Dual-specificity protein phosphatase; maintains low levels of both basal and induced cell integrity pathway signaling by dephosphorylation of the Slt2p MAPK; reciprocally regulated by Slt2p through phosphorylation; minor role with Ptp2p in the adaptive response to pheromone through the dephosphorylation of the Fus3p MAPK with major contribution by Ptp3p; inhibits the nuclear accumulation of Fus3p; two isoforms exist as the result of alternative translation initiation starts" /db_xref="GeneID:855674" /db_xref="SGD:S000004998" ORIGIN 1 mqfhsdkqhl dsktdidfkp nsprslqnrn tknlsldiaa lhplmefssp sqdvpgsvkf 61 psptplnlfm kpkpivlekc ppkvsprptp pslsmrrsea siytlptslk nrtvspsvyt 121 ksstvssisk lssssplssf sekphlnrvh slsvktkdlk lkgirgrsqt isgletstpi 181 sstregtlds tdvnrfsnqk nmqttlifpe edsdlnidmv haeiyqrtvy ldgpllvlpp 241 nlylysepkl edilsfdlvi nvakeipnle flippemahk ikyyhiewth tskivkdlsr 301 ltriihtahs qgkkilvhcq cgvsrsasli vayimryygl slndaynklk gvakdispnm 361 glifqlmewg tmlsknspge egetvhmpee ddignnevss ttksyssasf rsfpmvtnls 421 sspndssvns sevtprtpat ltgartalat ergeddehck slsqpadsle asvdnesist 481 apeqmmflp // LOCUS NP_014346 153 aa linear PLN 30-JUN-2025 DEFINITION cytochrome c oxidase subunit Va [Saccharomyces cerevisiae S288C]. ACCESSION NP_014346 VERSION NP_014346.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182891.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10493. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..153 /product="cytochrome c oxidase subunit Va" /calculated_mol_wt="17009" Region 21..153 /region_name="Cyt_c_Oxidase_IV" /note="Cytochrome c oxidase subunit IV. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; cd00922" /db_xref="CDD:238462" Site 27 /site_type="other" /note="Subunit IV/Vb interface [polypeptide binding]" /db_xref="CDD:238462" Site order(33,35,37..40,57,59,61,69,73..74,76..77,79..82,85) /site_type="other" /note="Subunit IV/Va interface [polypeptide binding]" /db_xref="CDD:238462" Site order(34..36,91,98,102,106,110,118,120,123..124) /site_type="other" /note="Subunit IV/I interface [polypeptide binding]" /db_xref="CDD:238462" Site order(35,135..136,139,143,145..147) /site_type="other" /note="Subunit IV/II interface [polypeptide binding]" /db_xref="CDD:238462" Site order(35,86,88,91..92) /site_type="other" /note="putative ATP/ADP binding site [chemical binding]" /db_xref="CDD:238462" Site order(93..94,100..101,103..105,107..108,124,127,130..131, 134,138,147,151) /site_type="other" /note="Subunit IV/VIIb interface [polypeptide binding]" /db_xref="CDD:238462" Site order(140,145) /site_type="other" /note="Subunit IV/VIc interface [polypeptide binding]" /db_xref="CDD:238462" CDS 1..153 /gene="COX5A" /locus_tag="YNL052W" /coded_by="NM_001182891.1:1..462" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006123 mitochondrial electron transport, cytochrome c to oxygen [PMID:1331058]" /experiment="EXISTENCE:direct assay:GO:0045277 respiratory chain complex IV [PMID:1331058]" /experiment="EXISTENCE:mutant phenotype:GO:0004129 cytochrome-c oxidase activity [PMID:1847916]" /note="Subunit Va of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Ap is predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth; COX5A has a paralog, COX5B, that arose from the whole genome duplication" /db_xref="GeneID:855675" /db_xref="SGD:S000004997" ORIGIN 1 mlrntftrag glsritsvrf aqthalsnaa vmdlqsrwen mpsteqqdiv sklserqklp 61 waqltepekq avwyisygew gprrpvlnkg dssfiakgva agllfsvglf avvrmaggqd 121 aktmnkewql ksdeylkskn anpwggysqv qsk // LOCUS NP_014347 403 aa linear PLN 30-JUN-2025 DEFINITION Golgi transport complex subunit COG5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014347 VERSION NP_014347.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182890.1 REFERENCE 1 (residues 1 to 403) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 403) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 403) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 403) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 403) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10494. Method: conceptual translation. FEATURES Location/Qualifiers source 1..403 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..403 /product="Golgi transport complex subunit COG5" /calculated_mol_wt="45473" Region 14..146 /region_name="COG5" /note="Golgi transport complex subunit 5; pfam10392" /db_xref="CDD:192566" CDS 1..403 /gene="COG5" /locus_tag="YNL051W" /gene_synonym="API4; COD4" /coded_by="NM_001182890.1:1..1212" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /note="Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" /db_xref="GeneID:855676" /db_xref="SGD:S000004996" ORIGIN 1 mtiapmandl edfesllepd fdakqfgndl lkatnnndtt ildlntplkk lnydlheids 61 ridqlmnsnp leiieliykn ehvnstivge lkpslgymnm sydrlknqvl dpyerarkvq 121 lalskvyqts fllrgallyi hlsnklnals ktaqlststa inlaslhyql eitleenknl 181 kslrkikqld qdivspnkre litflslqmc keclnsikik snkeiisqla yslyllssqe 241 fesainkivl snvtmssqil skilnsirmf pdafnevvek gyniyiletl lqniktdnvt 301 nssrsiaank srlgnllsey tsmkskagsg tprdlfwskv ssafkkdfdi svnrggpvgk 361 sllknkdfii ntmkqsmkks sdnsdyqsyl dvmlnsvsis lnk // LOCUS NP_014348 270 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL050C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014348 VERSION NP_014348.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182889.3 REFERENCE 1 (residues 1 to 270) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 270) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 270) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 270) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10495. On Jul 30, 2012 this sequence version replaced NP_014348.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..270 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..270 /product="uncharacterized protein" /calculated_mol_wt="31306" Region 80..186 /region_name="DUF2011" /note="Fungal protein of unknown function (DUF2011); pfam09428" /db_xref="CDD:430605" CDS 1..270 /locus_tag="YNL050C" /coded_by="NM_001182889.3:1..813" /note="hypothetical protein; YNL050c is not an essential gene" /db_xref="GeneID:855677" /db_xref="SGD:S000004995" ORIGIN 1 msefkivsrk dlynegeglg edydsnsssk nnsehvevlv pptefefvev ertdssldlk 61 esnnsaheqk eekqeefefp lfsfgvveas tspaqeeqgs stqekdtpqt evslmkislk 121 epeeeiinqe rpkdyyfasy sadqklqfqq ssidydviiq estkileddl rirdkwpycq 181 griidlykhn arieleqqke lkikkrrpgq kqraakklal ertkerdtka reikkqlkkk 241 fhkrggkknk kkvplnplak agstpkfrte // LOCUS NP_014349 876 aa linear PLN 30-JUN-2025 DEFINITION COPII subunit SFB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014349 VERSION NP_014349.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182888.1 REFERENCE 1 (residues 1 to 876) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 876) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 876) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 876) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10496. Method: conceptual translation. FEATURES Location/Qualifiers source 1..876 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..876 /product="COPII subunit SFB2" /calculated_mol_wt="98813" Region 1..876 /region_name="COG5028" /note="Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion]" /db_xref="CDD:227361" CDS 1..876 /gene="SFB2" /locus_tag="YNL049C" /gene_synonym="ISS1" /coded_by="NM_001182888.1:1..2631" /experiment="EXISTENCE:direct assay:GO:0090110 COPII-coated vesicle cargo loading [PMID:10712514]" /experiment="EXISTENCE:genetic interaction:GO:0090110 COPII-coated vesicle cargo loading [PMID:10712514|PMID:12941277]" /experiment="EXISTENCE:physical interaction:GO:0030127 COPII vesicle coat [PMID:10749860|PMID:10753972]" /note="Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SFB2 has a paralog, SEC24, that arose from the whole genome duplication" /db_xref="GeneID:855678" /db_xref="SGD:S000004994" ORIGIN 1 mshhkkrvyp qaqvpyiasm pivaeqqqsq qqidqtayam gnlqlnnran sftqlaqnqq 61 fpgsgkvvnq lypvdlftel pppirdlslp plpitisqdn ivtpseysnv pyqyvrstlk 121 avpktnsllk ktklpfaivi rpylhlqdsd nqvplntdgv ivrcrrcrsy mnpfvvfinq 181 grkwqcnicr fkndvpfgfd qnlqgapinr yerneiknsv vdylapveys vrepppsvyv 241 flldvsqnav kngllatsar tilenieflp nhdgrtriai icvdhslhyf yvpldddyev 301 sdeddeesdg eeededeeee dvdnsetiqm fdigdldepf lpmpsdelvv plkycknnle 361 tllkkipeif qdthsskfal gpalkaasnl ikstggkvev isstlpntgi gklkkrseqg 421 ilntpkessq llsckdsfyk tftiecnklq itvdmflase dymdvatlsh lgrfsggqth 481 fypgfnatsl ndvtkftrel srhlsmdism eavmrvrcst glratsffgh ffnrssdlca 541 fstmprdqsy lfgisiedsl maeycylqvs tlltlntger rirvmtlalp tsesarevfa 601 sadqlaitdf mtqnavtkal nssmysardf itkslediln aykkeismsn insvtslnlc 661 anlrmlpllm nglskhialr pgvvpsdyra salnrletep lhyliksiyp tvyslhdmpd 721 evglpdfegk tvlpepinat islferygly lidnsaelfl wvggdavpel lidvfntdti 781 sqipvgksel pllndspfne rlrriigrir enndtitfqs lyiirgpsin epanlnsekd 841 maslrlwvls tlvedkvlnc asyreylqsm ktsinr // LOCUS NP_014350 548 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,2-mannosyltransferase ALG11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014350 VERSION NP_014350.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182887.1 REFERENCE 1 (residues 1 to 548) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 548) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 548) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 548) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10497. Method: conceptual translation. FEATURES Location/Qualifiers source 1..548 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..548 /product="alpha-1,2-mannosyltransferase ALG11" /EC_number="2.4.1.131" /calculated_mol_wt="63012" Region 72..529 /region_name="GT4_ALG11-like" /note="alpha-1,2-mannosyltransferase ALG11 and similar proteins; cd03806" /db_xref="CDD:340835" CDS 1..548 /gene="ALG11" /locus_tag="YNL048W" /coded_by="NM_001182887.1:1..1647" /experiment="EXISTENCE:direct assay:GO:0004377 GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity [PMID:16878994]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11278778]" /experiment="EXISTENCE:direct assay:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:16878994]" /experiment="EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:11278778]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:11278778]" /note="Alpha-1,2-mannosyltransferase; catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER" /db_xref="GeneID:855679" /db_xref="SGD:S000004993" ORIGIN 1 mgsawtnynf eevkshfgfk kyvvsslvlv yglikvltwi frqwvyssln pfskksslln 61 ravascgekn vkvfgffhpy cnaggggekv lwkavditlr kdaknviviy sgdfvngenv 121 tpenilnnvk akfdydldsd riffislklr ylvdsstwkh ftligqaigs milafesiiq 181 cppdiwidtm gypfsypiia rflrripivt ythypimskd mlnklfkmpk kgikvygkil 241 ywkvfmliyq sigskidivi tnstwtnnhi kqiwqsntck iiyppcstek lvdwkqkfgt 301 akgerlnqai vlaqfrpekr hkliiesfat flknlpdsvs piklimagst rskqdenyvk 361 slqdwsenvl kipkhlisfe knlpfdkiei llnkstfgvn amwnehfgia vveymasgli 421 pivhasagpl ldivtpwdan gnigkappqw elqkkyfakl eddgettgff fkepsdpdyn 481 ttkdplrypn lsdlflqitk ldydclrvmg arnqqyslyk fsdlkfdkdw enfvlnpick 541 lleeeerg // LOCUS NP_014351 656 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol 4,5-bisphosphate-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_014351 VERSION NP_014351.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182886.3 REFERENCE 1 (residues 1 to 656) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 656) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 656) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 656) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 656) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10498. On Jul 30, 2012 this sequence version replaced NP_014351.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..656 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..656 /product="phosphatidylinositol 4,5-bisphosphate-binding protein" /calculated_mol_wt="74654" Region 237..417 /region_name="BAR_4" /note="BAR-like domain; pfam20400" /db_xref="CDD:466549" Region 444..555 /region_name="PH_Slm1" /note="Slm1 Pleckstrin homology (PH) domain; cd13311" /db_xref="CDD:270121" Site order(455,460..462,516,536) /site_type="other" /note="non-cannonical phosphoinositide binding site [chemical binding]" /db_xref="CDD:270121" CDS 1..656 /gene="SLM2" /locus_tag="YNL047C" /gene_synonym="LIT1" /coded_by="NM_001182886.3:1..1971" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15689497|PMID:15372071]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0001558 regulation of cell growth [PMID:15689497]" /experiment="EXISTENCE:genetic interaction:GO:0016197 endosomal transport [PMID:21451250]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:15372071]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:15689497]" /experiment="EXISTENCE:genetic interaction:GO:0070941 eisosome assembly [PMID:21451250]" /experiment="EXISTENCE:genetic interaction:GO:0072659 protein localization to plasma membrane [PMID:22307609]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:15689497]" /experiment="EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:15689497]" /experiment="EXISTENCE:physical interaction:GO:0031929 TOR signaling [PMID:15689497]" /note="Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; TORC2 complex substrate and effector; SLM2 has a paralog, SLM1, that arose from the whole genome duplication" /db_xref="GeneID:855680" /db_xref="SGD:S000004992" ORIGIN 1 msyqrnsara sldlrsqyqq legrmrsehf npayqqqqqk gqniplslps slaqrnpipy 61 pidavtsdpt ipaqlnvydh drqnsivdaa agtntthsln snnipssqnn ninnnninnv 121 gsftdpsmlt lpkmslhshq kqydsnqndp rsplailipt saqptdvlsa rfsawrnvir 181 ailvylseta siqdeivrqq lrlshavqfp ffsienqyqp vsnedksmqk fflplgsgsv 241 qdlptmltky hdnlaslask sskeltseii prledlrrdl lvkikeikal qsdfknscnk 301 elqqtkhlmk lfneslkeck lgtpksdpfl iklqlekqik rqlveenylh eafdnlqnsg 361 aqlesvivme iqngltsyar ilgkeaqvvf dsviskldst ilnkntnlew dsfilrnisn 421 fvppnlpmrr fkeisysnqn dpftfevksg flekrskflk sysrgfyvlt psflhefktp 481 dkhkfstplm siplvectvt ehskktksns eqgknkfilr tnsnglihrg hnwvfkvdsy 541 ddmiewfgni kalsslpnyd dkckyvskva klskekaksn enttesvtpq vtneqhtryd 601 dvsssnfpln sipkldnlti tnttssipet ndsqiqnrvp efyienvdsp rksnql // LOCUS NP_014352 172 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL046W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014352 VERSION NP_014352.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182885.3 REFERENCE 1 (residues 1 to 172) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 172) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 172) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 172) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10499. On Jul 30, 2012 this sequence version replaced NP_014352.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..172 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..172 /product="uncharacterized protein" /calculated_mol_wt="19219" CDS 1..172 /locus_tag="YNL046W" /coded_by="NM_001182885.3:1..519" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="hypothetical protein; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)" /db_xref="GeneID:855681" /db_xref="SGD:S000004991" ORIGIN 1 mehvskrsig qffkrktstv dgsksqkcgt tnqlrkllhk rrvqkqavpv esqyripgdf 61 rdnqsvrvkn smynsspsvt psthhinery vrydintrpl vvvlaisivf fgcllvlkdi 121 iiqssenils vskwkiigas fmgtpytgll tglvgpllsp fsavsswlsf if // LOCUS NP_014353 671 aa linear PLN 30-JUN-2025 DEFINITION bifunctional aminopeptidase/epoxide hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014353 VERSION NP_014353.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182884.1 REFERENCE 1 (residues 1 to 671) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 671) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 671) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 671) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10500. Method: conceptual translation. FEATURES Location/Qualifiers source 1..671 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..671 /product="bifunctional aminopeptidase/epoxide hydrolase" /EC_number="3.3.2.10" /calculated_mol_wt="77222" Region 57..669 /region_name="leuko_A4_hydro" /note="leukotriene A-4 hydrolase/aminopeptidase; TIGR02411" /db_xref="CDD:274120" CDS 1..671 /gene="LAP2" /locus_tag="YNL045W" /coded_by="NM_001182884.1:1..2016" /experiment="EXISTENCE:direct assay:GO:0004177 aminopeptidase activity [PMID:10574934]" /experiment="EXISTENCE:direct assay:GO:0004301 epoxide hydrolase activity [PMID:10574934]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006629 lipid metabolic process [PMID:10574934]" /experiment="EXISTENCE:direct assay:GO:0030163 protein catabolic process [PMID:10574934]" /note="Leucyl aminopeptidase yscIV with epoxide hydrolase activity; metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; also known as leukotriene A4 hydrolase" /db_xref="GeneID:855682" /db_xref="SGD:S000004990" ORIGIN 1 mfllpfvirh sssiylptlr frglltvisr nihistphkm lplsieqrrp srspeydqst 61 lsnykdfavl htdlnlsvsf eksaisgsvt fqlkklhegk nksdelhldt syldvqevhi 121 dgskadfqie qrkeplgsrl vinnascndn ftlniqfrtt dkctalqwln skqtkggkpy 181 vfsqleaiha rslfpcfdtp svkstftasi esplpvvfsg iriedtskdt niyrfeqkvp 241 ipayligias gdlssapigp rstvytepfr lkdcqwefen dvekfiqtae kiifeyewgt 301 ydilvnvdsy pyggmespnm tfatptliah drsnidviah elahswsgnl vtncswnhfw 361 lnegwtvyle rriigaihge ptrhfsalig wsdlqnsids mkdperfstl vqnlndntdp 421 ddafstvpye kgfnllfhle tilggkaefd pfirhyfkkf akksldtfqf ldtlyefype 481 kkeildsvdw etwlykpgmp prphfitala dnvyqladkw vemaqhlktt edfrsefnai 541 dikdfnsnql vlfletltqn ghsnkkpkdf dwakfpvasr alldiyqdni vksqnaevvf 601 kmfkfqifak lqeeykhlad wlgtvgrmkf vrpgyrllns vdrrlalatf dkfkdtyhpi 661 ckalvkqdlg l // LOCUS NP_014354 176 aa linear PLN 30-JUN-2025 DEFINITION Yip3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014354 VERSION NP_014354.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182883.1 REFERENCE 1 (residues 1 to 176) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 176) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 176) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 176) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10501. On Jan 7, 2000 this sequence version replaced NP_014354.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..176 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..176 /product="Yip3p" /calculated_mol_wt="19281" Region 1..176 /region_name="YIP3" /note="Prenylated rab acceptor 1 and related proteins [Intracellular trafficking and secretion / Signal transduction mechanisms]; COG5130" /db_xref="CDD:227459" CDS 1..176 /gene="YIP3" /locus_tag="YNL044W" /coded_by="NM_001182883.1:1..531" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16002643]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:16002643]" /experiment="EXISTENCE:direct assay:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:11157978]" /experiment="EXISTENCE:direct assay:GO:0030134 COPII-coated ER to Golgi transport vesicle [PMID:11157978]" /note="Protein localized to COPII vesicles; proposed to be involved in ER-to-Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p; integral membrane protein that localizes to the ER, the Golgi apparatus, transport vesicles and the peroxisome; two isoforms exist, a full-length Yip3L (Yip3 Long) and a shorter peroxisomal matrix isoform Yip3S (Yip3 Short)" /db_xref="GeneID:855683" /db_xref="SGD:S000004989" ORIGIN 1 mnqlgalaqv srftqnfsme niksefqslq sklatlrtpq effnfkkisk pqnfgevqsr 61 vaynlkyfss nygliigcls iytlltnlll lfvivlvvag ivginklkge elvtpfgsfk 121 tnqlytglvc vavpigflas pistllwlig asavsvfgha slmekpietv fdeetv // LOCUS NP_878157 85 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL042W-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878157 VERSION NP_878157.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184662.3 REFERENCE 1 (residues 1 to 85) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 85) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 85) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 85) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10502. On Jul 30, 2012 this sequence version replaced NP_878157.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..85 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..85 /product="uncharacterized protein" /calculated_mol_wt="9801" CDS 1..85 /locus_tag="YNL042W-B" /coded_by="NM_001184662.3:1..258" /note="hypothetical protein" /db_xref="GeneID:1466515" /db_xref="SGD:S000028850" ORIGIN 1 milalgdflp kqedkacerp wvqfparpvi ffhhqggifl fsinqpnlsc fsklkevnsl 61 yvrvatyicq knesrfrtnr lkgdq // LOCUS NP_014356 396 aa linear PLN 30-JUN-2025 DEFINITION Bop3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014356 VERSION NP_014356.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182881.1 REFERENCE 1 (residues 1 to 396) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 396) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 396) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 396) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10503. Method: conceptual translation. FEATURES Location/Qualifiers source 1..396 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..396 /product="Bop3p" /calculated_mol_wt="43618" Region 4..396 /region_name="DUF2722" /note="Protein of unknown function (DUF2722); pfam10846" /db_xref="CDD:371267" CDS 1..396 /gene="BOP3" /locus_tag="YNL042W" /coded_by="NM_001182881.1:1..1191" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0071406 cellular response to methylmercury [PMID:15796894]" /note="hypothetical protein; potential Cdc28p substrate; overproduction confers resistance to methylmercury" /db_xref="GeneID:855686" /db_xref="SGD:S000004987" ORIGIN 1 mstfnsysqp kesndnshnn vnkskslldi ifgtnvsewa fsenalmkam dlkieqektk 61 qqyyklenln rsielfklas ssglpinqih klfntdhgvp asspmkaggn qphnntegtq 121 ssenlprlng smkslkplnm ntvsptpmsr qpspykfpas sstggishst vtnvqrrans 181 parigasava alndnisike edvarripsg tksqesplnk kptslhsrnl slpigkftnp 241 nipstmtsil sfnrdqqqpl sqplppppqq qqdlhthnlh tiprkpgmvq kkhrrarsts 301 sfgvidlsii deakekqvqr spspihsnvs valtshdkpi esnmkeqpnm lqsvregrqv 361 hddlddrtcs esssrnespv rtitkdnsvg kilnst // LOCUS NP_014357 839 aa linear PLN 30-JUN-2025 DEFINITION Golgi transport complex subunit COG6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014357 VERSION NP_014357.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182880.1 REFERENCE 1 (residues 1 to 839) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 839) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 839) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 839) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 839) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 839) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 839) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 839) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10504. Method: conceptual translation. FEATURES Location/Qualifiers source 1..839 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..839 /product="Golgi transport complex subunit COG6" /calculated_mol_wt="96845" Region 195..834 /region_name="COG6" /note="Conserved oligomeric complex COG6; smart01087" /db_xref="CDD:215018" CDS 1..839 /gene="COG6" /locus_tag="YNL041C" /gene_synonym="COD2; SEC37" /coded_by="NM_001182880.1:1..2520" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /note="Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" /db_xref="GeneID:855687" /db_xref="SGD:S000004986" ORIGIN 1 mdfvvdyqty amadtatpel pepeprlnlt sdaqsqptgk ldlqfklpdl qrysnnnatl 61 pvdndgagsk dlhkkmthya mssidkiqls npskqlgqns qdeklsqqes qnftnyepkn 121 ldlsklvsps sgsnknttnl vlsnklskil nnytlinyqa tvqlrkslkv leenkerlsl 181 deqklmnpey vgtlarralr tdlesqllke hitvleefkp iirrikrlss svekiqrtse 241 kllsnetnev ptnnvvlqei dqyrlkaeql klkkkillsi rdrftlnqve ddvitngtid 301 niffevvkkv inikdessfl ltlpnlnagn alimgvneil ektnkkifny lidflysfes 361 ssnllndhgt teqeslnifr kslvflssdl elfnellkrv ttlrsksild eflsqfdmns 421 ttskpiilsa hdpiryigdv lasvhsiian eadfvkslfd fqdedlkdtp isilqqnktf 481 lkgidnklln diiqslsnsc ririeqivrf eenpiinfei vrllklyrvm ferkgiqdds 541 siinnlksle disknriigy yedymkqtvm aetknssddl lppewlseym nklvelfeiy 601 ekthaaedee sednkllssk nlqtiveqpi kdvllkqlqt sfplakknek ekaslltiei 661 ncfdliksrl qpfeglfaqd ddsrkitiwv cdklkeytkq mltlqikflf entgldlysn 721 lvnmifpvds vkdeldydmy lalrdnslme ldmvrknvhd klnyylpqal tdvqgnllfk 781 ltspmiadei cdecfkklsl fynifrklli hlypnkkdqv feilnfstde fdmligidh // LOCUS NP_001418072 26 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL040C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001418072 VERSION NP_001418072.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001431143.1 REFERENCE 1 (residues 1 to 26) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 26) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 26) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 26) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 26) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 26) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 26) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 26) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DBA54443. Method: conceptual translation. FEATURES Location/Qualifiers source 1..26 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..26 /product="uncharacterized protein" /calculated_mol_wt="2581" CDS 1..26 /locus_tag="YNL040C-A" /coded_by="NM_001431143.1:1..81" /note="hypothetical protein; deletion confers sensitivity to osmotic stress" /db_xref="GeneID:91000625" /db_xref="SGD:S000350098" ORIGIN 1 mpeqkancsp ngnitvdsmi mslgss // LOCUS NP_014358 456 aa linear PLN 30-JUN-2025 DEFINITION putative alanine--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014358 VERSION NP_014358.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182879.3 REFERENCE 1 (residues 1 to 456) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 456) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 456) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 456) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10505. On Jul 30, 2012 this sequence version replaced NP_014358.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..456 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..456 /product="putative alanine--tRNA ligase" /calculated_mol_wt="50833" Region 25..275 /region_name="AlaX" /note="Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis]; COG2872" /db_xref="CDD:442119" CDS 1..456 /locus_tag="YNL040W" /coded_by="NM_001182879.3:1..1371" /experiment="EXISTENCE:direct assay:GO:0002196 Ser-tRNA(Ala) deacylase activity [PMID:38869066]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043905 L-seryl-tRNA(Thr) hydrolase activity [PMID:38869066]" /experiment="EXISTENCE:genetic interaction:GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity [PMID:38869066]" /experiment="EXISTENCE:mutant phenotype:GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity [PMID:38869066]" /note="Ser-tRNA(Ala) hydrolase; hydrolyzes Ser-mischarged cytoplasmic and mitochondrial tRNAs; regulates translational fidelity based on Ala- and Thr-to-Ser misincorporation in the null mutant; trans-editing factor for alanyl- and threonyl-tRNA synthetases and seryl-tRNA synthetase (SerRS) via hydrolysis; null mutant displays decreased translation rate and increased readthrough of premature stop codons; (GFP)-fusion protein localizes to the cytoplasm; homologous to human trans-editing factor AARSD" /db_xref="GeneID:855688" /db_xref="SGD:S000004985" ORIGIN 1 mptpmtpvkv galacqrnsf lfdgfktlvv sceptknkkg eiegyeielq dtilfpeggg 61 qpsdsgflki vegnrnsski ekilvshvsr fglhakhhvn dyiepgttve vavdeqkrmd 121 ymqqhtgqhl lsailernyk vdtvswsmgg iitkkkpvle psdyfnyiel nrkltldeit 181 nvsdeinqli infpqeiive erigeetvde vstskipddy dlskgvlrti higdidsnpc 241 cgthlkctsq igsililsnq savrgsnsrl yfmcgkrvsl yaksvnkill dsknllscse 301 tqisekitrq tkqiqqlnkr eqywikrlar taseelmntl kasgkkrayf meeeygtlel 361 llqihkevsn flkddtegye iilcgyerqt ntgsllilse sgekianlaa nlgsilqnlk 421 ggggkkggkw qgkitsisna efaalsdyls hdfasc // LOCUS NP_014359 594 aa linear PLN 30-JUN-2025 DEFINITION transcription factor TFIIIB subunit BDP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014359 VERSION NP_014359.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182878.3 REFERENCE 1 (residues 1 to 594) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 594) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 594) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 594) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 594) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10506. On Jul 30, 2012 this sequence version replaced NP_014359.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..594 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..594 /product="transcription factor TFIIIB subunit BDP1" /calculated_mol_wt="67557" Region 34..566 /region_name="BDP1" /note="Transcription initiation factor TFIIIB, Bdp1 subunit [Transcription]; COG5118" /db_xref="CDD:227448" CDS 1..594 /gene="BDP1" /locus_tag="YNL039W" /gene_synonym="TFC5; TFC7" /coded_by="NM_001182878.3:1..1785" /experiment="EXISTENCE:direct assay:GO:0000126 transcription factor TFIIIB complex [PMID:1458536|PMID:7568218]" /experiment="EXISTENCE:direct assay:GO:0001156 TFIIIC-class transcription factor complex binding [PMID:12930823]" /experiment="EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11387215]" /experiment="EXISTENCE:mutant phenotype:GO:0001112 DNA-templated transcription open complex formation [PMID:11387215]" /experiment="EXISTENCE:mutant phenotype:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11387215]" /experiment="EXISTENCE:physical interaction:GO:0001156 TFIIIC-class transcription factor complex binding [PMID:12930823]" /note="Essential subunit of RNA polymerase III transcription factor (TFIIIB); TFIIIB is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs" /db_xref="GeneID:855689" /db_xref="SGD:S000004984" ORIGIN 1 mssivnksgt rfapkvrqrr aatggtptpk prtpqlfipe skeieednsd ndkgvdenet 61 aivekpslvg erslegftlt gtnghdneig degpidastq npkadviedn vtlkpaplqt 121 hrdqkvprss rlaslskdne srpsfkpsfl dsssnsngta rrlstisnkl pkkirlgsit 181 endmnlktfk rhrvlgkpss akkpagahri sivskisppt amtdsldrne fssetstsre 241 adenenyvis kvkdipkkvr dgesakyfid eenftmaelc kpnfpigqis enfekskmak 301 kaklekrrhl relrmrarqe fkplhsltke eqeeeeekrk eerdkllnad ipesdrkaht 361 aiqlklnpdg tmaideetmv vdrhknasie neykekvden pfanlynygs ygrgsytdpw 421 tveemikfyk alsmwgtdfn lisqlypyrs rkqvkakfvn eekkrpilie lalrsklppn 481 fdeycceikk nigtvadfne klielqnehk hhmkeieeak ntakeedqta qrlndanlnk 541 kgsggimtnd lkvyrktevv lgtiddlkrk klkernnddn ednegseeep eidq // LOCUS NP_014360 229 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol N-acetylglucosaminyltransferase GPI15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014360 VERSION NP_014360.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182877.1 REFERENCE 1 (residues 1 to 229) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 229) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 229) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 229) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 229) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10507. On Oct 2, 2003 this sequence version replaced NP_014360.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..229 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..229 /product="phosphatidylinositol N-acetylglucosaminyltransferase GPI15" /EC_number="2.4.1.198" /calculated_mol_wt="26686" Region 123..197 /region_name="PIG-H" /note="GPI-GlcNAc transferase complex, PIG-H component; pfam10181" /db_xref="CDD:462983" CDS 1..229 /gene="GPI15" /locus_tag="YNL038W" /coded_by="NM_001182877.1:1..690" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:11746600]" /experiment="EXISTENCE:mutant phenotype:GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity [PMID:11746600]" /note="Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol" /db_xref="GeneID:855690" /db_xref="SGD:S000004983" ORIGIN 1 miskeyefgk tsilnrkkyt lvidedkngn firftvlpvs nrkfkkvkqn grveinmgiq 61 yhqivlilll nilfyviclr srflehinrt fevtiarsfq iliimglfal gtiilvrgps 121 vetvtifkes glqlsrvkgm vifpqqwnrk ffeqvefisn eriidvvine gfcrgfrvif 181 ylaaivrkss tlkllfpsnl psiddqrliy nisrkylskq ekplsrpkd // LOCUS NP_014361 360 aa linear PLN 30-JUN-2025 DEFINITION isocitrate dehydrogenase (NAD(+)) IDH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014361 VERSION NP_014361.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182876.1 REFERENCE 1 (residues 1 to 360) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 360) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 360) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 360) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10508. Method: conceptual translation. FEATURES Location/Qualifiers source 1..360 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..360 /product="isocitrate dehydrogenase (NAD(+)) IDH1" /EC_number="1.1.1.41" /calculated_mol_wt="39193" Region 26..357 /region_name="mito_nad_idh" /note="isocitrate dehydrogenase, NAD-dependent, mitochondrial type; TIGR00175" /db_xref="CDD:272942" CDS 1..360 /gene="IDH1" /locus_tag="YNL037C" /coded_by="NM_001182876.1:1..1083" /experiment="EXISTENCE:direct assay:GO:0004449 isocitrate dehydrogenase (NAD+) activity [PMID:16884682]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8626605]" /experiment="EXISTENCE:direct assay:GO:0006102 isocitrate metabolic process [PMID:16884682]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:direct assay:GO:0045242 isocitrate dehydrogenase complex (NAD+) [PMID:16884682]" /note="Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle" /db_xref="GeneID:855691" /db_xref="SGD:S000004982" ORIGIN 1 mlnrtiakrt lataaqaert lpkkyggrft vtlipgdgvg keitdsvrti feaenipidw 61 etinikqtdh kegvyeaves lkrnkiglkg lwhtpadqtg hgslnvalrk qldiyanval 121 fkslkgvktr ipdidlivir entegefsgl ehesvpgvve slkvmtrpkt eriarfafdf 181 akkynrksvt avhkanimkl gdglfrniit eigqkeypdi dvssiivdna smqavakphq 241 fdvlvtpsmy gtilgnigaa liggpglvag anfgrdyavf epgsrhvgld ikgqnvanpt 301 amilsstlml nhlglneyat riskavheti aegkhttrdi ggsssttdft neiinklstm // LOCUS NP_014362 221 aa linear PLN 30-JUN-2025 DEFINITION carbonate dehydratase NCE103 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014362 VERSION NP_014362.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182875.3 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10509. On Jul 30, 2012 this sequence version replaced NP_014362.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..221 /product="carbonate dehydratase NCE103" /EC_number="4.2.1.1" /calculated_mol_wt="24728" Region 25..212 /region_name="beta_CA_cladeA" /note="Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; cd00883" /db_xref="CDD:238448" Site order(48,50,57,59..61,72,75,97,102,112,115,202) /site_type="active" /note="active site clefts [active]" /db_xref="CDD:238448" Site order(57,59,112,115) /site_type="other" /note="zinc binding site [ion binding]" /db_xref="CDD:238448" Site order(58..61,63,65..66,67,72..74,76,78,92..93,96..97,140, 202,204..205,207,209) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238448" CDS 1..221 /gene="NCE103" /locus_tag="YNL036W" /gene_synonym="NCE3" /coded_by="NM_001182875.3:1..666" /experiment="EXISTENCE:direct assay:GO:0004089 carbonate dehydratase activity [PMID:15813743|PMID:15096093]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15096093]" /experiment="EXISTENCE:mutant phenotype:GO:0071244 cellular response to carbon dioxide [PMID:22253597]" /note="Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate, which is an important metabolic substrate, and protons; not expressed under conditions of high CO2, such as inside a growing colony, but transcription is induced in response to low CO2 levels, such as on the colony surface in ambient air; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; abundance increases in response to DNA replication stress" /db_xref="GeneID:855692" /db_xref="SGD:S000004981" ORIGIN 1 msatesssif tlshnsnlqd ilaanakwas qmnniqptlf pdhnakgqsp htlfigcsds 61 rynenclgvl pgevftwknv anichsedlt lkatlefaii clkvnkviic ghtdcggikt 121 cltnqrealp kvncshlyky lddidtmyhe esqnlihlkt qrekshylsh cnvkrqfnri 181 ienptvqtav qngelqvygl lynvedgllq tvstytkvtp k // LOCUS NP_014363 389 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL035C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014363 VERSION NP_014363.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182874.1 REFERENCE 1 (residues 1 to 389) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 389) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 389) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 389) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 389) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10510. Method: conceptual translation. FEATURES Location/Qualifiers source 1..389 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..389 /product="uncharacterized protein" /calculated_mol_wt="43717" Region <29..320 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 59..98 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 106..144 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 151..183 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 242..282 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..389 /locus_tag="YNL035C" /coded_by="NM_001182874.1:1..1170" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /note="Nuclear hypothetical protein; relocalizes to the cytosol in response to hypoxia; contains WD-40 domains; not an essential gene; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855695" /db_xref="SGD:S000004980" ORIGIN 1 masyslvesn sfgsenwclk lqpsykhgll tglsngeirl ldwstgksvq kikasetain 61 dmkvigsdfs aghlvssasi davkvfdirt ndriaqiqne anspfislds rhgllacgte 121 lqgidaavyi ydirkwdtpl rslidshhdd vtcikfhpsd vnillsgstd gytniydlkq 181 deeedalhqv inyasihscg wlspkriftl shmetfaihe lndksdelke pqpldfgdvr 241 eiwncdyvvd iypgliatgk tqencgelcl lpfkdekvdt engiviphah gdevvrdifi 301 paqhsnmlys cgedgcvkiw enkqgpldip enfwdyskkm nvlgdddreg sinldeplii 361 qkesvstrpr kekhkkakkh smksrfkpy // LOCUS NP_014364 612 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL034W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014364 VERSION NP_014364.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182873.1 REFERENCE 1 (residues 1 to 612) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 612) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 612) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 612) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10511. Method: conceptual translation. FEATURES Location/Qualifiers source 1..612 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..612 /product="uncharacterized protein" /calculated_mol_wt="69243" CDS 1..612 /locus_tag="YNL034W" /coded_by="NM_001182873.1:1..1839" /experiment="EXISTENCE:mutant phenotype:GO:0043935 sexual sporulation resulting in formation of a cellular spore [PMID:36441813]" /note="Protein required for sporulation; induced during meiosis and sporulation; gene is a member of Centroid, a centromere-linked gene family; not an essential gene; YNL034W has a paralog, YNL018C, that arose from a segmental duplication" /db_xref="GeneID:855697" /db_xref="SGD:S000004979" ORIGIN 1 mstsfqefka fcnkvgldfq wlnlqssksv pesgssegfs avsdtvqeni rpateplnvn 61 qskdpvsnff ydvknaplwn vykrnhsghs steacsgvss gqasknipea mvketvlsnh 121 dnvtiinell ptssamhqee stamttsyll shsvndscnv mlsssshnra mlppslvqrn 181 nattspttds asennesvps ltssvstsss vysswnpphs phissfpdgn faslnaevtc 241 fdfrrtkdsr tketnesiip teiycpinst dhhkhypsqk skqdacapap rnqniscsvg 301 saaefsqsnh tlttvvpsym qqyldrpqnw feskmgkycp lflrstknid ydslefkfer 361 kmiavqylll deqseprryy npsnksipfw krpfnfdtmp sydqlmeeae crfysyqyky 421 egfqriepys ifcpwkntqr eidlvldhih fsldvgekks lnrkgnitld tldskvdpni 481 qikpyqifps nnlvyeglph paeqslilsp gtslierafq alidickesi ppsndcttrn 541 hnsapqltvp epskpcrlll vresrtatel etnkklwlhs qrrnievtvp mhpsehgtks 601 rlrkwlstfv hq // LOCUS NP_014365 284 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL033W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014365 VERSION NP_014365.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182872.3 REFERENCE 1 (residues 1 to 284) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 284) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 284) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 284) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10512. On Jul 30, 2012 this sequence version replaced NP_014365.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..284 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..284 /product="uncharacterized protein" /calculated_mol_wt="31255" CDS 1..284 /locus_tag="YNL033W" /coded_by="NM_001182872.3:1..855" /note="hypothetical protein; YNL033W has a paralog, YNL019C, that arose from a segmental duplication" /db_xref="GeneID:855698" /db_xref="SGD:S000004978" ORIGIN 1 mlysresrtt vlflalvtsl tvlchsvdvt tvfttstite ittvtaapqp qnkaetalnt 61 atniiqtmqf lfncapfkwk gplkitscal nfivllltaw gyllkylqen klnsdadmek 121 mvglgfgemv grifgkgvgk aftkmditqk lvypfegsnr qkcllmtvge nsivpfhdlf 181 teicfdqytl dslshhnhgs isildagsvs algfadissk mpsvselytl fgdytievlg 241 gitklastln redwqgerng favlsrdrpn qtllsvhmys ssll // LOCUS NP_014366 281 aa linear PLN 30-JUN-2025 DEFINITION putative tyrosine protein phosphatase SIW14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014366 VERSION NP_014366.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182871.3 REFERENCE 1 (residues 1 to 281) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 281) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 281) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 281) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10513. On Jul 30, 2012 this sequence version replaced NP_014366.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..281 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..281 /product="putative tyrosine protein phosphatase SIW14" /EC_number="3.6.1.52" /calculated_mol_wt="32624" Region 115..263 /region_name="PFA-DSP_Siw14" /note="atypical dual specificity phosphatases similar to yeast Siw14; cd14528" /db_xref="CDD:350377" CDS 1..281 /gene="SIW14" /locus_tag="YNL032W" /gene_synonym="OCA3" /coded_by="NM_001182871.3:1..846" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [PMID:26828065|PMID:29540476]" /experiment="EXISTENCE:direct assay:GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [PMID:29540476]" /experiment="EXISTENCE:direct assay:GO:0106211 inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity [PMID:29540476]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:15020461]" /experiment="EXISTENCE:mutant phenotype:GO:0052845 inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity [PMID:29540476|PMID:26828065]" /experiment="EXISTENCE:mutant phenotype:GO:0052847 inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity [PMID:29540476]" /experiment="EXISTENCE:mutant phenotype:GO:0071543 diphosphoinositol polyphosphate metabolic process [PMID:26828065]" /experiment="EXISTENCE:mutant phenotype:GO:0106211 inositol-5-diphosphate-1,3,4,6-tetrakisphosphate diphosphatase activity [PMID:29540476]" /note="Inositol phosphatase involved in inositol pyrophosphate metabolism; hydrolyzes the beta-phosphate from the 5-diphosphate group of PP-InsPs including: 5PP-IP5 (IP7), 1,5PP-IP4 (IP8) and 5-PP-InsP4; functions as an anti-prion (anti-[PSI]) component; member of the atypical dual-specificity subgroup of the protein tyrosine-phosphatase (PTP) superfamily; localizes to the cytoplasm" /db_xref="GeneID:855699" /db_xref="SGD:S000004977" ORIGIN 1 mglyqaknde gsdpkssski ddlieneaei irlikedgkl lidngdgrdi hniiqedkll 61 svefnevlkr fhgeeksdip rkefdededd gydsnehhqk tievmntlnh vinkevippe 121 nfshvvgeiy rssfprqenf sflherlklk silvlipeey pqenlnflkl tgiklyqvgm 181 sgnkepfvni pshlltkale ivlnpanqpi lihcnrgkhr tgcligcirk lqnwsltmif 241 deyrrfafpk araldqqfie mydddeikri asknnwlplq w // LOCUS NP_014367 136 aa linear PLN 30-JUN-2025 DEFINITION histone H3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014367 VERSION NP_014367.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182870.1 REFERENCE 1 (residues 1 to 136) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 136) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 136) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 136) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10514. Method: conceptual translation. FEATURES Location/Qualifiers source 1..136 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..136 /product="histone H3" /calculated_mol_wt="15225" Region 1..136 /region_name="PTZ00018" /note="histone H3; Provisional" /db_xref="CDD:185400" Site order(40..48,50,64..67,70,73,84..87,117..119,121) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:467036" Site order(45,48,51..52,55..56,58,60,62..63,67..68,70..72, 74..75,77,79,82..86,88..89,92..93,96..98,100..102,104..106, 109,118..122,126,129) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467036" Site order(49,52..53,56..57,59,95,99,102,109,113,118) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467036" Site order(107,110..111,114..115,117,123..124,127..128,130..132) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:467036" CDS 1..136 /gene="HHT2" /locus_tag="YNL031C" /coded_by="NM_001182870.1:1..411" /experiment="EXISTENCE:direct assay:GO:0008823 cupric reductase (NADH) activity [PMID:32631887]" /experiment="EXISTENCE:mutant phenotype:GO:0006878 intracellular copper ion homeostasis [PMID:32631887]" /experiment="EXISTENCE:mutant phenotype:GO:0008823 cupric reductase (NADH) activity [PMID:32631887]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:32631887]" /note="Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage" /db_xref="GeneID:855700" /db_xref="SGD:S000004976" ORIGIN 1 martkqtark stggkaprkq laskaarksa pstggvkkph rykpgtvalr eirrfqkste 61 llirklpfqr lvreiaqdfk tdlrfqssai galqesveay lvslfedtnl aaihakrvti 121 qkkdiklarr lrgers // LOCUS NP_014368 103 aa linear PLN 30-JUN-2025 DEFINITION histone H4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014368 VERSION NP_014368.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182869.1 REFERENCE 1 (residues 1 to 103) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 103) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 103) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 103) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 103) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10515. Method: conceptual translation. FEATURES Location/Qualifiers source 1..103 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..103 /product="histone H4" /calculated_mol_wt="11237" Region 18..101 /region_name="PTZ00015" /note="histone H4; Provisional" /db_xref="CDD:185397" CDS 1..103 /gene="HHF2" /locus_tag="YNL030W" /coded_by="NM_001182869.1:1..312" /note="Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity" /db_xref="GeneID:855701" /db_xref="SGD:S000004975" ORIGIN 1 msgrgkggkg lgkggakrhr kilrdniqgi tkpairrlar rggvkrisgl iyeevravlk 61 sflesvirds vtytehakrk tvtsldvvya lkrqgrtlyg fgg // LOCUS NP_014369 522 aa linear PLN 30-JUN-2025 DEFINITION putative mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014369 VERSION NP_014369.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182868.3 REFERENCE 1 (residues 1 to 522) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 522) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 522) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 522) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10516. On Jul 30, 2012 this sequence version replaced NP_014369.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..522 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..522 /product="putative mannosyltransferase" /calculated_mol_wt="61597" Region 6..499 /region_name="KTR1" /note="Mannosyltransferase [Carbohydrate transport and metabolism]; COG5020" /db_xref="CDD:227353" CDS 1..522 /gene="KTR5" /locus_tag="YNL029C" /coded_by="NM_001182868.3:1..1569" /experiment="EXISTENCE:curator inference:GO:0097502 mannosylation [PMID:9090056]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR5 has a paralog, KTR7, that arose from the whole genome duplication" /db_xref="GeneID:855703" /db_xref="SGD:S000004974" ORIGIN 1 mllirrtina flgcihcnlt atciliafvi tmyvvlvsep asvdgtmgnf lpfskmdlat 61 krdrpfysnc vntqdyllnp syikqnasfv mltrngeled viktinsiee hfnqwfhypy 121 vflndqpfee dfkakvrdvt vgalvefgti deiswnfpsd vkdtfefyna iedqgdrsil 181 ygnlesyhkm crfysglfyk hplvqkyewy wrlepdveff cditydpfle mlrtnkkygf 241 tiiipelywt vpnlfrhtks fisqkgvtlg slwklftkdy difesddpel rdwinydfqa 301 kakisekiai eqllkkgddf qqinddkegi mnlihkarsr khivedkffn eeynlchfws 361 nfeiarlsvf dndiynsffq yleksggfwk erwgdapvhs iglsltldld dvhyfrdigy 421 rhstiqhcph namgneefsy lasdskfkrk naaydegref gcgcrcrcpk kkreiedsmg 481 fcvniwvnll nqqrgherhv ealngnemee hiredylrqf gn // LOCUS NP_014371 678 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding transcription factor CRZ1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014371 VERSION NP_014371.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182866.1 REFERENCE 1 (residues 1 to 678) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 678) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 678) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 678) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 678) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10517. Method: conceptual translation. FEATURES Location/Qualifiers source 1..678 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..678 /product="DNA-binding transcription factor CRZ1" /calculated_mol_wt="76170" Region 139..617 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 571..591 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(576,578,580,582..583,586..587,590,604,606,610..611, 614..615,618,641,643,645,647..648,651..652,655) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 598..656 /region_name="Zn_ribbon_recom" /note="Recombinase zinc beta ribbon domain; pfam13408" /db_xref="CDD:433183" Region 599..619 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 627..655 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..678 /gene="CRZ1" /locus_tag="YNL027W" /gene_synonym="HAL8; TCN1" /coded_by="NM_001182866.1:1..2037" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:11523797]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:20412803|PMID:11523797]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10197980]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10197980]" /experiment="EXISTENCE:direct assay:GO:0010765 positive regulation of sodium ion transport [PMID:11523797]" /experiment="EXISTENCE:direct assay:GO:0030007 intracellular potassium ion homeostasis [PMID:20412803]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20412803|PMID:11523797]" /experiment="EXISTENCE:direct assay:GO:0071483 cellular response to blue light [PMID:23335962]" /experiment="EXISTENCE:genetic interaction:GO:0006031 chitin biosynthetic process [PMID:21343301]" /experiment="EXISTENCE:genetic interaction:GO:0030007 intracellular potassium ion homeostasis [PMID:20412803]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20412803|PMID:9407035|PMID:25258318]" /experiment="EXISTENCE:genetic interaction:GO:0050801 monoatomic ion homeostasis [PMID:9407035]" /experiment="EXISTENCE:genetic interaction:GO:0071277 cellular response to calcium ion [PMID:9407035]" /experiment="EXISTENCE:mutant phenotype:GO:0030007 intracellular potassium ion homeostasis [PMID:20412803]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9407035|PMID:9407036|PMID:9559673|PMID:20412803|PMID :15299026|PMID:11523797]" /experiment="EXISTENCE:mutant phenotype:GO:0050801 monoatomic ion homeostasis [PMID:9407035]" /experiment="EXISTENCE:mutant phenotype:GO:0071277 cellular response to calcium ion [PMID:9407036|PMID:11523797|PMID:9407035]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:9407035|PMID:9407036]" /experiment="EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:15299026|PMID:11523797]" /experiment="EXISTENCE:mutant phenotype:GO:0071475 cellular hyperosmotic salinity response [PMID:11523797|PMID:9407035|PMID:9559673]" /experiment="EXISTENCE:mutant phenotype:GO:2001040 positive regulation of cellular response to drug [PMID:17056742]" /note="Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress; can be activated in stochastic pulses of nuclear localization in response to calcium" /db_xref="GeneID:855704" /db_xref="SGD:S000004972" ORIGIN 1 msfsngnmas ymtssngeeq sinnkndidd nsayrrnnfr nssnsgshtf qlsdldldvd 61 mrmdsansse kisknlssgi pdsfdsnvns llspssgsys adlnyqslyk pdlpqqqlqq 121 qqlqqqqqqq qqqqqqqqkq tptlkveqsd tfqwddiltp adnqhrpslt nqflsprsny 181 dgttrssgid snysdtesny htpylypqdl vsspamshlt annddfddll svasmnsnyl 241 lpvnshgykh isnldelddl lsltysdnnl lsasnnsdfn nsnngiinta dtqnstiain 301 kskvgtnqkm lltiptsstp spsthaapvt piisiqefne ghfpvknedd gtlqlkvrdn 361 esysatnnnn llrpddndyn nealsdidrs fediingrkl klkksrrrss qtsnnsftsr 421 rssrsrsisp dekaksisan rekllemadl lpssendnnr erydndskts yntinssnfn 481 ednnnnnllt skpkiesgiv niknelddts kdlgilldid slgqfeqkvg fknddnhenn 541 dngtfsvkkn dnlekldsvt nnrknpanfa cdvcgkkftr pynlkshlrt htnerpfics 601 icgkafarqh drkrhedlht gkkryvcggk lkdgkpwgcg kkfarsdalg rhfktesgrr 661 citplyeear qeksgqes // LOCUS NP_014372 484 aa linear PLN 30-JUN-2025 DEFINITION SAM complex subunit SAM50 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014372 VERSION NP_014372.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182865.1 REFERENCE 1 (residues 1 to 484) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 484) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 484) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 484) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10518. Method: conceptual translation. FEATURES Location/Qualifiers source 1..484 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..484 /product="SAM complex subunit SAM50" /calculated_mol_wt="54275" Region 151..479 /region_name="Omp85" /note="Omp85 superfamily domain; pfam01103" /db_xref="CDD:460065" CDS 1..484 /gene="SAM50" /locus_tag="YNL026W" /gene_synonym="OMP85; TOB55" /coded_by="NM_001182865.1:1..1455" /experiment="EXISTENCE:direct assay:GO:0001401 SAM complex [PMID:14570913]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14690591|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:14699090|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:14685243]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:18039934|PMID:14570913]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:14570913|PMID:14685243]" /note="Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85" /db_xref="GeneID:855705" /db_xref="SGD:S000004971" ORIGIN 1 mtsssgvdne isldspmpif nesstlkpir vagvvttgtd hidpsvlqay lddtimksit 61 lgqlvknadv lnkrlcqhhi alnakqsfhf qgntyisdek ethdvvplme vvsqldilpp 121 ktftaktgtn fgndndaeay lqfeklidkk ylklptrvnl eilrgtkihs sflfnsyssl 181 spqsilnlkv fsqfynwntn kgldigqrga rlslryeplf lhkllhnphs nesptlfhew 241 fletcwrstk icsqgtsapy mysgtmlsqa gdqlrtilgh tfvldkrdhi mcptkgsmlk 301 wsnelspgkh lktqlelnsv kswmnddfit fsttiktgyl knlssqqslp vhicdkfqsg 361 gpsdirgfqt fglgprdlyd avggdafvsy glsvfsrlpw kkveksnfrl hwffnggklv 421 nhdntslgnc igqlskehst stgiglvlrh pmarfelnft lpitahendl irkgfqfglg 481 lafl // LOCUS NP_014373 323 aa linear PLN 30-JUN-2025 DEFINITION cyclin-dependent protein serine/threonine kinase regulator SSN8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014373 VERSION NP_014373.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182864.3 REFERENCE 1 (residues 1 to 323) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 323) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 323) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 323) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10519. On Jul 30, 2012 this sequence version replaced NP_014373.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..323 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..323 /product="cyclin-dependent protein serine/threonine kinase regulator SSN8" /calculated_mol_wt="37660" Region 27..323 /region_name="CCL1" /note="Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]; COG5333" /db_xref="CDD:227640" CDS 1..323 /gene="SSN8" /locus_tag="YNL025C" /gene_synonym="CNC1; GIG3; NUT9; RYE2; SRB11; UME3" /coded_by="NM_001182864.3:1..972" /experiment="EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7877695]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:11383511|PMID:12200444]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14749387]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16109375]" /experiment="EXISTENCE:mutant phenotype:GO:0000411 positive regulation of transcription by galactose [PMID:15601835]" /experiment="EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7732022]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12455972]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:12455972]" /note="Cyclin-like component of RNA polymerase II holoenzyme; involved in phosphorylation of RNAPII C-terminal domain; forms kinase-cyclin pair in RNAPII holoenzyme with Ssn3p; needed for entry into and execution of meiotic program; involved in glucose repression, telomere maintenance; degraded in response to nitrogen starvation, and also to oxidative stress, but in different cellular compartments, and with different cellular outcomes; 35% identical to human cyclin C" /db_xref="GeneID:855706" /db_xref="SGD:S000004970" ORIGIN 1 msgsfwtstq rhhwqytkas lakerqklwl lecqlfpqgl nivmdskqng ieqsitknip 61 ithrdlhydk dynlriycyf limklgrrln irqyalatah iylsrflika svreinlyml 121 vttcvylack veecpqyirt lvseartlwp efippdptkv tefefyllee lesylivhhp 181 yqslkqivqv lkqppfqitl ssddlqncws lindsyindv hllypphiia vaclfitisi 241 hgkptkgssl asaaseaird pknssspvqi afnrfmaesl vdleevmdti qeqitlydhw 301 dkyheqwikf llhtlylrpa sai // LOCUS NP_878158 72 aa linear PLN 30-JUN-2025 DEFINITION Ksh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878158 VERSION NP_878158.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184619.3 REFERENCE 1 (residues 1 to 72) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 72) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 72) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 72) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10520. On Jul 30, 2012 this sequence version replaced NP_878158.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..72 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..72 /product="Ksh1p" /calculated_mol_wt="8065" Region 10..45 /region_name="DUF1242" /note="Protein of unknown function (DUF1242); pfam06842" /db_xref="CDD:462019" CDS 1..72 /gene="KSH1" /locus_tag="YNL024C-A" /coded_by="NM_001184619.3:1..219" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:19942856]" /note="Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and cytosol respectively; ortholog of human Kish" /db_xref="GeneID:1466516" /db_xref="SGD:S000028698" ORIGIN 1 msalfnfrsl lqvilllics csyvhgqwps lldryknhev lgafwkmarv geraspyvsl 61 acilmaisqf ns // LOCUS NP_014374 246 aa linear PLN 30-JUN-2025 DEFINITION putative protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014374 VERSION NP_014374.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182863.1 REFERENCE 1 (residues 1 to 246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 246) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10521. Method: conceptual translation. FEATURES Location/Qualifiers source 1..246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..246 /product="putative protein-lysine N-methyltransferase" /calculated_mol_wt="27607" Region 33..218 /region_name="Methyltransf_16" /note="Lysine methyltransferase; pfam10294" /db_xref="CDD:313513" CDS 1..246 /gene="EFM6" /locus_tag="YNL024C" /coded_by="NM_001182863.1:1..741" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative S-adenosylmethionine-dependent lysine methyltransferase; responsible for modifying Lys-390 in translational elongation factor EF-1 alpha (eEF1A); has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:855707" /db_xref="SGD:S000004969" ORIGIN 1 mesifggfgd lvvprpkehl gqtdlsfggk llpalkiced ggesgcggkv wiagellcey 61 ileksvdhll sktvngtkqf kkvlelgsgt glvglcvgll ekntfhdgtk vyvtdidkli 121 pllkrnield evqyevlare lwwgeplsad fspqegamqa nnvdlvlaad cvyleeafpl 181 lektlldlth cinppvilma ykkrrkadkh ffnkikrnfd vleitdfskf ehylkerthl 241 fqlirk // LOCUS NP_014375 965 aa linear PLN 30-JUN-2025 DEFINITION Fap1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014375 VERSION NP_014375.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182862.1 REFERENCE 1 (residues 1 to 965) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 965) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 965) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 965) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 965) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 965) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 965) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 965) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10522. Method: conceptual translation. FEATURES Location/Qualifiers source 1..965 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..965 /product="Fap1p" /calculated_mol_wt="108364" Region 66..118 /region_name="RING-CH-C4HC3_NFX1-like" /note="RING-CH finger, H2 subclass (C4HC3-type), found in transcriptional repressor NF-X1, NF-X1-type zinc finger protein NFXL1, and similar proteins; cd16492" /db_xref="CDD:438155" Region 150..196 /region_name="NF-X1-zinc-finger" /note="Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008" /db_xref="CDD:100116" Region 206..263 /region_name="NF-X1-zinc-finger" /note="Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008" /db_xref="CDD:100116" Region 352..400 /region_name="NF-X1-zinc-finger" /note="Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008" /db_xref="CDD:100116" Region 458..505 /region_name="NF-X1-zinc-finger" /note="Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008" /db_xref="CDD:100116" Region 604..655 /region_name="NF-X1-zinc-finger" /note="Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger...; cd06008" /db_xref="CDD:100116" Region 736..794 /region_name="R3H_unknown_2" /note="R3H domain of a group of fungal proteins with unknown function. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a...; cd06006" /db_xref="CDD:100076" Site order(765,769) /site_type="other" /note="RxxxH motif" /db_xref="CDD:100076" CDS 1..965 /gene="FAP1" /locus_tag="YNL023C" /coded_by="NM_001182862.1:1..2898" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:36113412]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:36113412|PMID:10998178]" /experiment="EXISTENCE:direct assay:GO:0070651 nonfunctional rRNA decay [PMID:36113412]" /note="Cytoplasmic RING-finger E3 Ub-ligase and sensor of stalled ribosomes; binds to Fpr1p and Smu2p, and triggers K63-linked polyubiquitination of monoubiquitinated 40S subunit Rps3p, from decoding-defective ribosomes, followed by dissociation of the 80S ribosomes and non-functional rRNA decay (NRD) of 18S rRNA; confers rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus in rapamycin-treated cells; ortholog of D. melanogaster shuttle craft and human NFX1" /db_xref="GeneID:855708" /db_xref="SGD:S000004968" ORIGIN 1 mteheslgle qnqdggdtyr hhnlsdgcis svedaneqps syeeesdddm qyyeraiqei 61 ssgdsyvcmi ctvemdytcq mfackrcyrv fdygcirewa lkstektvdr iwkcpncyyv 121 skrvpvknrp tcwcgkvvnp dpnpldpnsc gqtcnastcm hgcskichlg phpectrmve 181 imchcgkhsk sifcyqskvm kknfncqevc glplscsiht ckkkchpglc gpcpemiisk 241 dspkkqikcy cgnhtranik csetkfpksg ksskdengnr wigvfacadn rvvdyscrkh 301 sfiescispp tingekacpf lpsslktcpc grtaleeltk prkhcddpip tcdsrcgkpl 361 kcgkhscpft chdkacmepc lqidsvkcac eqstfsvpcg fqgrprcnik ceslmscrrh 421 rctdrccsgr psairrkknl frtqdlldes lveakhiclk pcnltlscgi hkcqrkchpg 481 kcppclesds ndlvcpcgnt vvpapvrcgt klptcnhpci kvvrgestcg hkpmphtchs 541 ldvscppcte tvfkpckcgk ktkvrtvcfq tdvscgikcg iplsycyhtc qktchlpgnc 601 qkvckqtcgq krlncnhecp kpchgktecp dlpcatlvki yckcgrikks vtcgaksdrv 661 svtessvldc neecealkrl kelkeafgik eetnnftsne ldalkklvsv attfeelqlp 721 fteaalsvys kqerwcsqie ailnklmddk trsslhfkpm rppqrhfire lakayglyse 781 sqdrepmrsv fikkedngas nkpvlslaea yplyesfkql qkerkaqefq arttaklinf 841 evqdtepkve vakkngflvq nlvagntaed lrrffephlk htlvvnpqyl ilddgktalv 901 ypenyetasv nterdmellv ghfdfmakea fladsislcs teeelerrld tpviqedspv 961 mdnnt // LOCUS NP_014376 490 aa linear PLN 30-JUN-2025 DEFINITION rRNA (cytosine-C5-)-methyltransferase RCM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014376 VERSION NP_014376.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182861.3 REFERENCE 1 (residues 1 to 490) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 490) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 490) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 490) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 490) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10523. On Jul 30, 2012 this sequence version replaced NP_014376.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..490 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..490 /product="rRNA (cytosine-C5-)-methyltransferase RCM1" /EC_number="2.1.1.311" /calculated_mol_wt="56046" Region <147..489 /region_name="RsmB" /note="16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; COG0144" /db_xref="CDD:439914" CDS 1..490 /gene="RCM1" /locus_tag="YNL022C" /coded_by="NM_001182861.3:1..1473" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10649453]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:23913415]" /experiment="EXISTENCE:direct assay:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:direct assay:GO:0070475 rRNA base methylation [PMID:23913415]" /experiment="EXISTENCE:genetic interaction:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:genetic interaction:GO:0070475 rRNA base methylation [PMID:23913415]" /experiment="EXISTENCE:mutant phenotype:GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity [PMID:23913415]" /experiment="EXISTENCE:mutant phenotype:GO:0070475 rRNA base methylation [PMID:23913415]" /note="rRNA m5C methyltransferase; methylates cytosine at position 2278 of 25S rRNA while Nop2p methylates cytosine at position 2870; contains seven beta-strand methyltransferase motif; localized to the nucleolus; interacts with Trm112p; homolog of NSUN5A, a human gene which is deleted in Williams-Beuren Syndrome" /db_xref="GeneID:855709" /db_xref="SGD:S000004967" ORIGIN 1 mnfyrdatwv lediekeaak erisgsmqtl vlksckrykl ksnpkhiyav ldscwkykpy 61 lekvmkkahi ledipkkkgk plfsrltlll lchdlllskq kriqmgkhpi kdyvlkfksp 121 lhsemvklkl klkvrelsel vlsedisndl ppvrwirinp lkchpngete pvlaelrkkf 181 tlkvdkwsel vpgsiyydef ipnlfgihps dkitahelyk hgkiiiqdra scfpahilnp 241 gpsdividsc sapgnkttht asyiypeppk dnntriyafe kdperakvlq kmikiagcsp 301 nisvnvgdft klatpekykd vtcfivdpsc sgsgifgrkf fdsfnrrkid dkdddggivp 361 deqeefiake elqtrlakls sfqfqmvkha msfpaakkiv ystcsihaee nervvidlll 421 dksvrewgwk vapkrevips wprrgkveef eevfrdgvty dpqqlaegci ralpksdggi 481 gffavcferd // LOCUS NP_014377 706 aa linear PLN 30-JUN-2025 DEFINITION histone deacetylase HDA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014377 VERSION NP_014377.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182860.1 REFERENCE 1 (residues 1 to 706) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 706) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 706) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 706) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10524. Method: conceptual translation. FEATURES Location/Qualifiers source 1..706 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..706 /product="histone deacetylase HDA1" /EC_number="3.5.1.98" /calculated_mol_wt="79939" Region 81..403 /region_name="HDAC_Clr3" /note="Class II Histone deacetylase Clr3 and similar proteins; cd11600" /db_xref="CDD:212542" Site order(205..206,214..215,245,247,338,376) /site_type="active" /note="putative active site [active]" /db_xref="CDD:212542" Region 457..698 /region_name="Arb2" /note="Arb2 domain; pfam09757" /db_xref="CDD:401634" CDS 1..706 /gene="HDA1" /locus_tag="YNL021W" /coded_by="NM_001182860.1:1..2121" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16415367]" /experiment="EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:19573535]" /experiment="EXISTENCE:direct assay:GO:0070823 HDA1 complex [PMID:8663039|PMID:11287668|PMID:8962081]" /experiment="EXISTENCE:genetic interaction:GO:0010621 negative regulation of transcription by transcription factor localization [PMID:17974563]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17121596|PMID:11172717]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17706600]" /experiment="EXISTENCE:physical interaction:GO:0070823 HDA1 complex [PMID:11287668]" /note="Catalytic subunit of class II HDA1 histone deacetylase complex; role in azole resistance via Hsp90p, and in heat shock response; Hda1p interacts with Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation; the HDA1 histone deacetylase complex regulates aging through trehalose metabolism" /db_xref="GeneID:855710" /db_xref="SGD:S000004966" ORIGIN 1 mdsvmvkkev lenpdhdlkr kleenkeeen slsttskskr qvivpvcmpk ihysplktgl 61 cydvrmryha kiftsyfeyi dphpedprri yriykilaen glindptlsg vddlgdlmlk 121 ipvraatsee ilevhtkehl efiestekms reellketek gdsvyfnnds yasarlpcgg 181 aieackavve grvknslavv rppghhaepq aaggfclfsn vavaaknilk nypesvrrim 241 ildwdihhgn gtqksfyqdd qvlyvslhrf emgkyypgti qgqydqtgeg kgegfncnit 301 wpvggvgdae ymwafeqvvm pmgrefkpdl viissgfdaa dgdtigqchv tpscyghmth 361 mlkslargnl cvvleggynl daiarsalsv akvligeppd elpdplsdpk peviemidkv 421 irlqskywnc frrrhansgc nfnepindsi isknfplqka irqqqqhyls defnfvtlpl 481 vsmdlpdntv lctpnisesn tiiivvhdts diwakrnvis gtidlsssvi idnsldfikw 541 gldrkygiid vnipltlfep dnysgmitsq evliylwdny ikyfpsvaki afigigdsys 601 givhllghrd travtktvin flgdkqlkpl vplvdetlse wyfknslifs nnshqcwken 661 esrkprkkfg rvlrcdtdgl nniieerfee atdfildsfe ewsdee // LOCUS NP_014378 638 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase ARK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014378 VERSION NP_014378.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182859.1 REFERENCE 1 (residues 1 to 638) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 638) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 638) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 638) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 638) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 638) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 638) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 638) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10525. Method: conceptual translation. FEATURES Location/Qualifiers source 1..638 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..638 /product="serine/threonine protein kinase ARK1" /EC_number="2.7.11.1" /calculated_mol_wt="71242" Region 18..301 /region_name="STKc_NAK_like" /note="Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; cd14037" /db_xref="CDD:270939" Site order(28..32,36,54,56,86,109..112,116,118,159,161,163..164, 166,177,180,205..208) /site_type="active" /db_xref="CDD:270939" Site order(28..32,36,54,56,86,109..112,116,159,161,163..164,166, 177) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270939" Site order(32,116,118,159,161,163,180,205..208) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270939" Site order(176..190,192..208) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270939" CDS 1..638 /gene="ARK1" /locus_tag="YNL020C" /coded_by="NM_001182859.1:1..1917" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:17978096]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:10087264]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:2000369 regulation of clathrin-dependent endocytosis [PMID:12956961]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:10087264]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:10087264]" /experiment="EXISTENCE:mutant phenotype:GO:2000369 regulation of clathrin-dependent endocytosis [PMID:12956961]" /note="Ser/Thr protein kinase; phosphorylates Pan1p-Sla1p-End3p protein complex subunits, Pan1p and Sla1p; involved in regulation of the cortical actin cytoskeleton and endocytosis; functional overlap with PRK1" /db_xref="GeneID:855711" /db_xref="SGD:S000004965" ORIGIN 1 mnqpqigtyn vgtqltvgsh qveiikylts ggfaqvysal inppdphsns svaclkrviv 61 pdkpslntlr aevdamrllk nnryvvsyid shaakamlhn gsyevfvlme ycergglidf 121 mntrlqnrlh efeilqimsq vtqgvaamha lqpplihrdi kienvlisan neyklcdfgs 181 vcgiirpprn sqelsyvqqd ilknttaqyr spemidtfrg lpideksdiw algiflyklc 241 yyttpfekgg dlailsgkfe fplypnyseq lkglirdilv qdprhrpnvy qllkrisimq 301 nvpcpindiq vvqapsshln ltelhqlsat qnilslnspt tmentmpnat fqismadntt 361 taqmhpnrkp sqiaydasfs nsakgsqplf dksqnmyhal dpplveplas svsnndnelk 421 ansatklkqa ivseahtfrq nnsidfplqn iipqyedsss ssdesysgdv delkktrslg 481 systrgnikk nqsvkeslts sslpgtsftp tstkvnlkhe nspfkstfvn tidnskddln 541 kpsyedldvs kqnlknsiqq rmidklnsse esfnarkmsk vklhekgeid kptmlkssgp 601 iskdkktkpt pppkpshlkp kpppkpllla grklsldk // LOCUS NP_014379 284 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL019C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014379 VERSION NP_014379.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182858.3 REFERENCE 1 (residues 1 to 284) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 284) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 284) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 284) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10526. On Jul 30, 2012 this sequence version replaced NP_014379.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..284 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..284 /product="uncharacterized protein" /calculated_mol_wt="31195" CDS 1..284 /locus_tag="YNL019C" /coded_by="NM_001182858.3:1..855" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /note="hypothetical protein; expression induced during heat stress; YNL019C has a paralog, YNL033W, that arose from a segmental duplication" /db_xref="GeneID:855712" /db_xref="SGD:S000004964" ORIGIN 1 mlysresrtt vlflalvtsl tvlchsvdvt tvfttstite ittvtaapqp qnkaetalnt 61 atniiqtmqf lfncapfkwk gplkitscal nfivllltaw gyllkylqen klnsdadmek 121 mvglgfgemv grifgkgvgk aftkmditqk lvypfegsnr qkcllmtvge nsivpfhdls 181 teicfdqytl dslshhnhgs isildagsvs algfadissk mpsvselytl fgdytievlg 241 gitklastln redwqgerng favlsrdrpn qtllsvhmys ssll // LOCUS NP_014380 612 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL018C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014380 VERSION NP_014380.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182857.3 REFERENCE 1 (residues 1 to 612) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 612) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 612) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 612) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10527. On Jul 30, 2012 this sequence version replaced NP_014380.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..612 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..612 /product="uncharacterized protein" /calculated_mol_wt="69421" CDS 1..612 /locus_tag="YNL018C" /coded_by="NM_001182857.3:1..1839" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0043935 sexual sporulation resulting in formation of a cellular spore [PMID:36441813]" /note="Protein required for sporulation; induced during meiosis and sporulation; gene is a member of Centroid, a centromere-linked gene family; YNL018C has a paralog, YNL034W, that arose from a segmental duplication" /db_xref="GeneID:855713" /db_xref="SGD:S000004963" ORIGIN 1 mstsfqefka fcnkvgldfq wlnlqssksv pengssegfs avsdtvqeni rpateplnvn 61 qskdpvsnff ydvknaplwn vykrnhsghs saeacsgvss rqapknipea mvketvlsnh 121 dnvtiinell ptssamhqee stamttsyll shsvndtcnv mfsssshnra mlpsslvqrn 181 nattspttds asennesvps ltssvstsss vysswnpphs phissfpdgn faslnaevtc 241 fdfrrtkdsr tketnesiip teiycptnst dhhkhypsrk skqdacapap cnqniscsvv 301 staefsqsnh tlttvvpsym qqyldrpqnw feskmgkycp lflrstknid ydslefkfer 361 kmiavqylll deqseprryy npsnksipfw krpfnfdtmp sydqlmeeae crfysyqyky 421 egfqriepys iscpwkntqr eidlvldhih fsldvgekks lnrkgnitld tldskvdpni 481 qikpyqifps nnlvyeglph paeqslilsp dtslierafq alidickesi pssndcstrn 541 nnsapqltvp epskpcrlll vresrtatel ktnkklwlhs qrrnievtvp mhpsergtks 601 wlrkwlstfv hq // LOCUS NP_014382 453 aa linear PLN 30-JUN-2025 DEFINITION Pub1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014382 VERSION NP_014382.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182855.1 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10528. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..453 /product="Pub1p" /calculated_mol_wt="50632" Region 77..150 /region_name="RRM1_PUB1" /note="RNA recognition motif 1 (RRM1) found in yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1 and similar proteins; cd12614" /db_xref="CDD:410026" Region 161..240 /region_name="RRM2_PUB1" /note="RNA recognition motif 2 (RRM2) found in yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1 and similar proteins; cd12619" /db_xref="CDD:410031" Region 341..414 /region_name="RRM3_PUB1" /note="RNA recognition motif 3 (RRM3) found in yeast nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1 and similar proteins; cd12622" /db_xref="CDD:410033" CDS 1..453 /gene="PUB1" /locus_tag="YNL016W" /gene_synonym="RNP1" /coded_by="NM_001182855.1:1..1362" /experiment="EXISTENCE:direct assay:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:10892745]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:8413212|PMID:15964806|PMID:8413213|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8413212]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8413212|PMID:8413213]" /experiment="EXISTENCE:direct assay:GO:0008266 poly(U) RNA binding [PMID:8413213]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:18981231|PMID:24291094|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:28467675]" /experiment="EXISTENCE:mutant phenotype:GO:0003729 mRNA binding [PMID:8413213|PMID:8413212]" /experiment="EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:28467675]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0043488 regulation of mRNA stability [PMID:15964806]" /experiment="EXISTENCE:physical interaction:GO:0006415 translational termination [PMID:28467675]" /note="Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds cell wall mRNAs; required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; implicated in regulation of translation; carries Q/N-rich domain at C- terminus, identified as candidate prion; ribosome-bound Pub1p modulates stop codon decoding during translation termination" /db_xref="GeneID:855716" /db_xref="SGD:S000004961" ORIGIN 1 msenneeqhq qqqqqqpvav etpsaveapa sadpsseqsv avegnseqae dnqgendpsv 61 vpanaitggr etsdrvlyvg nldkaitedi lkqyfqvggp ianikimidk nnknvnyafv 121 eyhqshdani alqtlngkqi ennivkinwa fqsqqsssdd tfnlfvgdln vnvddetlrn 181 afkdfpsyls ghvmwdmqtg ssrgygfvsf tsqddaqnam dsmqgqdlng rplrinwaak 241 rdnnnnnnyq qrrnygnnnr ggfrqynsnn nnnmnmgmnm nmnmnmnnsr gmppssmgmp 301 igamplpsqg qpqqsqtigl ppqvnpqavd hiirsapprv ttayigniph fateadlipl 361 fqnfgfildf khypekgccf ikydtheqaa vcivalanfp fqgrnlrtgw gkersnfmpq 421 qqqqggqpli mndqqqpvms eqqqqqqqqq qqq // LOCUS NP_014383 75 aa linear PLN 30-JUN-2025 DEFINITION Pbi2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014383 VERSION NP_014383.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182854.1 REFERENCE 1 (residues 1 to 75) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 75) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 75) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 75) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 75) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10529. Method: conceptual translation. FEATURES Location/Qualifiers source 1..75 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..75 /product="Pbi2p" /calculated_mol_wt="8459" CDS 1..75 /gene="PBI2" /locus_tag="YNL015W" /gene_synonym="LMA1" /coded_by="NM_001182854.1:1..228" /experiment="EXISTENCE:direct assay:GO:0004866 endopeptidase inhibitor activity [PMID:2015812]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9159115|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:9159115]" /experiment="EXISTENCE:mutant phenotype:GO:0030162 regulation of proteolysis [PMID:2015812]" /note="Cytosolic inhibitor of vacuolar proteinase B (PRB1); required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855717" /db_xref="SGD:S000004960" ORIGIN 1 mtknfivtlk kntpdveakk fldsvhhagg sivhefdiik gytikvpdvl hlnklkekhn 61 dvienveedk evhtn // LOCUS NP_014384 1044 aa linear PLN 30-JUN-2025 DEFINITION translation elongation factor EF-3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014384 VERSION NP_014384.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182853.3 REFERENCE 1 (residues 1 to 1044) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1044) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1044) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1044) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1044) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1044) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1044) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1044) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10530. On Jul 30, 2012 this sequence version replaced NP_014384.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1044 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1044 /product="translation elongation factor EF-3" /calculated_mol_wt="115738" Site order(108..109,112,115..116,147..148,151,154..155,158, 188..189,192,195..196,199,224..225,228,231..232,264..265, 268,271..272) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 129..158 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 170..200 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 208..232 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 244..273 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 336..411 /region_name="4HB" /note="Four helical bundle domain; pfam17947" /db_xref="CDD:407796" Region 437..973 /region_name="Uup" /note="ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; COG0488" /db_xref="CDD:440254" Region 794..861 /region_name="CD_eEF3" /note="chromodomain-like insertion in an ATPase domain of elongation factor eEF3; cd18626" /db_xref="CDD:349276" Site order(795..799,814,829..832,836,838..841,843..844,852, 855..856) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:349276" Site 813 /site_type="other" /note="ABC2 interface [polypeptide binding]" /db_xref="CDD:349276" CDS 1..1044 /gene="HEF3" /locus_tag="YNL014W" /gene_synonym="ZRG7" /coded_by="NM_001182853.3:1..3135" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9544245]" /experiment="EXISTENCE:genetic interaction:GO:0003746 translation elongation factor activity [PMID:9544245]" /experiment="EXISTENCE:genetic interaction:GO:0006414 translational elongation [PMID:9544245]" /experiment="EXISTENCE:physical interaction:GO:0022626 cytosolic ribosome [PMID:9544245]" /note="Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication" /db_xref="GeneID:855718" /db_xref="SGD:S000004959" ORIGIN 1 msdsqqsitv leelfrklet atsetregis selssflngn iiehdvpevf fdefqkaiqs 61 kqkalntlga vayianetnl spsvepyiva tvpsvcskag skdndvqlaa tkalkaiasa 121 vnpvavkall phlihslets nkwkekvavl evisvlvdaa keqialrmpe lipvlsesmw 181 dtkkgvkeaa tttitkatet vdnkdierfi pkliecianp nevpetvhll gattfvaevt 241 patlsimvpl lsrglaeret sikrkaavii dnmcklvedp qvvapflgkl lpglknnfat 301 iadpearevt lkalktlrrv gnvgeddvlp eishagdvst tlgvikelle pekvaprfti 361 vveyiaaiaa nlideriidq qtwfthvtpy mtiflhekta keilddfrkr avdnipvgpn 421 fqdeedeged lcncefslay gakillnktq lrlkrgrryg lcgpngagks tlmrsiangq 481 vdgfptqdec rtvyvehdid nthsdmsvld fvysgnvgtk dvitsklkef gfsdemiemp 541 iaslsggwkm klalaravlk dadillldep tnhldtvnve wlvnylntcg itsvivshds 601 gfldkvcqyi ihyeglklrk ykgnlsefvq kcptaqsyye lgasdlefqf ptpgylegvk 661 tkqkaivkvs nmtfqypgtt kpqvsdvtfq cslssriavi gpngagkstl invltgellp 721 tsgevythen criayikqha fahieshldk tpseyiqwrf qtgedretmd ranrqinend 781 aeamnkifki egtprrvagi hsrrkfknty eyecsfllge nigmkserwv pmmsvdnawl 841 prgelieshs kmvaeidmke alasgqfral trkeielhca mlgldselvs hsrirglsgg 901 qkvklvlaac twqrphlivl deptnyldrd slgalskalk afeggviiit hsaeftknlt 961 devwavkdgk mtpsghnwva gqgagpriek keeegdkfda mgnkinsgkk ksklssaelr 1021 kkkkermkkk kemgdeyvss dedf // LOCUS NP_014386 631 aa linear PLN 30-JUN-2025 DEFINITION putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014386 VERSION NP_014386.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182851.1 REFERENCE 1 (residues 1 to 631) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 631) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 631) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 631) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10531. On Aug 9, 2000 this sequence version replaced NP_014386.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..631 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..631 /product="putative carboxylic ester hydrolase" /calculated_mol_wt="72056" Region 19..629 /region_name="PLAc" /note="Cytoplasmic phospholipase A2, catalytic subunit; smart00022" /db_xref="CDD:214474" CDS 1..631 /gene="SPO1" /locus_tag="YNL012W" /coded_by="NM_001182851.1:1..1896" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18756268]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10855497]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17179081]" /experiment="EXISTENCE:genetic interaction:GO:0032120 ascospore-type prospore membrane formation [PMID:22611022]" /experiment="EXISTENCE:genetic interaction:GO:0070583 spore membrane bending pathway [PMID:18756268]" /experiment="EXISTENCE:mutant phenotype:GO:0007127 meiosis I [PMID:10855497]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:10855497]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:26605945|PMID:22611022]" /experiment="EXISTENCE:mutant phenotype:GO:0070583 spore membrane bending pathway [PMID:18756268]" /note="Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B" /db_xref="GeneID:855720" /db_xref="SGD:S000004957" ORIGIN 1 mqkllfvfsv lltvvlatap fqvqcpsspl ireakhelcp eetlylkkkk iktknkliqf 61 lkslteakfs skfykrvlkd ppkigiaisg ggyrsmlvgt gfisqmndyg lfeysdyiag 121 lsggswilmd lvvqnfevks llqewdleed lllgipefdi seeeivtnak keyndndlkm 181 kkrqggslit sssnfyeqie eimnsieeip edymitkrnl nplarlkkif fpnntftgtd 241 akietfkkvl dfykslhlki kpkkmegfqi sftdywgkai vqrlkknfdd dpnhsfsfsk 301 lvnsskkfke csvpipifva nckngllsnv ifeftpfefg swenilrlfv klpylgskiv 361 sgkaekcinn fddlgfitat sssifnnvli fiwnlasqss reamkalnmv mgifglgkee 421 ifsiskdssr letdyavyqp npfylypekd nvltnknhly lvdggedgen iplrtlvipe 481 reldvifvld sssdidnypn gsklkrifek ldeenvhyqf pnnvktfthp ivigcnatkr 541 tghdsflpii iyhananhgn asntstfkit ynqsevssml ptgrgvfsnd ydlyyknclg 601 ciltkrtmdr lprkkkfspf clqcfkdycy s // LOCUS NP_014387 444 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNL011C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014387 VERSION NP_014387.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182850.1 REFERENCE 1 (residues 1 to 444) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 444) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 444) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 444) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10532. Method: conceptual translation. FEATURES Location/Qualifiers source 1..444 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..444 /product="uncharacterized protein" /calculated_mol_wt="49782" Region 3..427 /region_name="YvcK_like" /note="family of mostly uncharacterized proteins similar to B.subtilis YvcK; cd07187" /db_xref="CDD:132873" Site order(8..10,313..314,318,348..349) /site_type="other" /note="phosphate binding site [ion binding]" /db_xref="CDD:132873" Site order(38,42,56,59,142) /site_type="other" /note="putative substrate binding pocket [chemical binding]" /db_xref="CDD:132873" Site order(135,140,143..144,147..148,150..151,161,164..165) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:132873" CDS 1..444 /locus_tag="YNL011C" /coded_by="NM_001182850.1:1..1335" /note="hypothetical protein; YNL011C is not an essential gene" /db_xref="GeneID:855721" /db_xref="SGD:S000004956" ORIGIN 1 mnvvvcsggt atnsltpcfs nisilkghel tyilpisdng gstseilriv ggpaigdirs 61 rivrllqdeq lvelfghrlp ndkllakkew neivegshpi wknisievke mcrsfiihmq 121 aellkkikhs npfqfesasi gnffltgarl flgsldasie lmmrigrcsp lvhvipcint 181 nhthhisall tngemitgqs qishpsksvp kdnsiahsak fihllgsydd hlkillddee 241 eeaeeeyanp iyilpelkns qlhfdkldes qnlpapvhri lyinpygeei kpmgnprais 301 kvkkadmvvy sigslmtsll pililgnlae vilesnntkk vllinnkydr evfgldglhy 361 vqmiidsmsr aiagyrqskg vhsenddfew qdfitdivyl kngeieidet ifekhsirch 421 qiassdkmes eelekvlnqi glkn // LOCUS NP_014388 241 aa linear PLN 30-JUN-2025 DEFINITION putative phosphoric monoester hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014388 VERSION NP_014388.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182849.3 REFERENCE 1 (residues 1 to 241) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 241) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 241) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 241) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10533. On Jul 30, 2012 this sequence version replaced NP_014388.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..241 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..241 /product="putative phosphoric monoester hydrolase" /EC_number="3.1.3.50" /calculated_mol_wt="27349" Region 5..225 /region_name="HAD_Pase" /note="phosphatase, similar to Bacillus subtilis MtnX; belongs to the haloacid dehalogenase-like superfamily; cd07524" /db_xref="CDD:319826" Site order(9..13,18,20..21,55,98..99,150,178..180,182..183) /site_type="active" /db_xref="CDD:319826" CDS 1..241 /gene="PYP1" /locus_tag="YNL010W" /coded_by="NM_001182849.3:1..726" /experiment="EXISTENCE:direct assay:GO:0000121 sn-glycerol 1-phosphatase activity [PMID:26071590]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043136 sn-glycerol 3-phosphatase activity [PMID:30240188]" /experiment="EXISTENCE:direct assay:GO:0050286 sorbitol-6-phosphatase activity [PMID:30240188]" /experiment="EXISTENCE:direct assay:GO:0110130 ribitol-5-phosphatase activity [PMID:30240188]" /experiment="EXISTENCE:mutant phenotype:GO:0052646 alditol phosphate metabolic process [PMID:30240188]" /note="Sugar alcohol phosphatase; polyol phosphatase that hydrolyzes sorbitol-6-phosphate, ribitol-5-phosphate, and (D)-glycerol-3-phosphate, maintaining phosphoglucose isomerase (PGI) activity in the presence of PGI-inhibitory sugar alcohols; expression correlated with growth rate; GFP-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant displays increased glycogen accumulation; member of the haloacid dehalogenase (HAD) superfamily" /db_xref="GeneID:855722" /db_xref="SGD:S000004955" ORIGIN 1 mvkaviftdf dgtvtledsn dyltdtlgfg kekrlkvfeg vlddtksfrq gfmemlesih 61 tpfpecikil ekkirldpgf kdtfewaqen dvpvivvssg mkpiikvllt rlvgqesihk 121 idivsnevei dahdqwkiiy kdespfghdk srsidaykkk festlkageq rpvyfycgdg 181 vsdlsaakec dllfakrgkd lvtyckkqnv pfhefdtfkd ilasmkqvla gektvaelme 241 n // LOCUS NP_014389 420 aa linear PLN 30-JUN-2025 DEFINITION isocitrate dehydrogenase (NADP(+)) IDP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014389 VERSION NP_014389.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182848.3 REFERENCE 1 (residues 1 to 420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 420) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10534. On Jul 30, 2012 this sequence version replaced NP_014389.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..420 /product="isocitrate dehydrogenase (NADP(+)) IDP3" /EC_number="1.1.1.42" /calculated_mol_wt="47725" Region 1..407 /region_name="PRK08299" /note="NADP-dependent isocitrate dehydrogenase" /db_xref="CDD:236226" CDS 1..420 /gene="IDP3" /locus_tag="YNL009W" /coded_by="NM_001182848.3:1..1263" /experiment="EXISTENCE:direct assay:GO:0004450 isocitrate dehydrogenase (NADP+) activity [PMID:9452501]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:15001388]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:9452501]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:9452501]" /note="Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication" /db_xref="GeneID:855723" /db_xref="SGD:S000004954" ORIGIN 1 mskikvvhpi vemdgdeqtr viwklikekl ilpyldvdlk yydlsiqerd rtndqvtkds 61 syatlkygva vkcatitpde armkefnlke mwkspngtir nilggtvfre piiipkiprl 121 vphwekpiii grhafgdqyr atdikikkag klrlqfssdd gkenidlkvy efpksggiam 181 amfntndsik gfakasfela lkrklplfft tkntilknyd nqfkqifdnl fdkeykekfq 241 alkityehrl iddmvaqmlk skggfiiamk nydgdvqsdi vaqgfgslgl mtsilitpdg 301 ktfeseaahg tvtrhfrkhq rgeetstnsi asifawtrai iqrgkldntd dvikfgnlle 361 katldtvqvg gkmtkdlalm lgktnrssyv tteefideva krlqnmmlss nedkkgmckl // LOCUS NP_014390 676 aa linear PLN 30-JUN-2025 DEFINITION putative ubiquitin-protein ligase ASI3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014390 VERSION NP_014390.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182847.2 REFERENCE 1 (residues 1 to 676) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 676) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 676) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 676) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10535. On Apr 26, 2011 this sequence version replaced NP_014390.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..676 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..676 /product="putative ubiquitin-protein ligase ASI3" /EC_number="2.3.2.27" /calculated_mol_wt="77518" Region 621..673 /region_name="mRING-HC-C4C4_Asi1p-like" /note="Modified RING finger, HC subclass (C4C4-type), found in Saccharomyces cerevisiae amino acid sensor-independent protein Asi1p, Asi3p and similar proteins; cd16616" /db_xref="CDD:438278" CDS 1..676 /gene="ASI3" /locus_tag="YNL008C" /coded_by="NM_001182847.2:1..2031" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:17085444]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0097658 Asi complex [PMID:25236469]" /experiment="EXISTENCE:genetic interaction:GO:0004842 ubiquitin-protein transferase activity [PMID:11454748]" /experiment="EXISTENCE:genetic interaction:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:11454748]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25236469]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:25253722]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:17085444]" /note="Subunit of the inner nuclear membrane Asi ubiquitin ligase complex; Asi complex targets both misfolded proteins of the inner nuclear membrane-associated degradation (INMAD) pathway and regulators of sterol biosynthesis for ubiquitin-mediated degradation; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signaling by targeting latent unprocessed forms of Stp1p and Stp2p, maintaining the repressed state of gene expression in the absence of inducing amino acids" /db_xref="GeneID:855724" /db_xref="SGD:S000004953" ORIGIN 1 mstnilqhvk qllhnrdvfs ffhnktgnln yldnttqkpe vfvspnstiv saptldsfqa 61 lmekgnfttl qlakvgirmf fsysvskyav lcfstaiiln rltvmsslrs nstnirlplw 121 sktllhlvat lslvkallqi lsqfglmhel hvsdtdfyal svylfvalsd cieifisstt 181 nvpslicsdf siwglslnly iiskmpagqq higdnvellg avfhrlvihl velfhirayr 241 lcgevilnag fftafvtrty lngldfinic lihnyfpgff yistillasi giflkalfts 301 npfrslysry knlekwwrsn nyngeeefne ialslclllt sndykifkks dnvksvdeva 361 afsnsyvvsg hlnqlqstpe dllsrkemtt dsqlpgfart ylglfelvrt iiltysrllk 421 nllwsknfes sidkkprvgk rkkrdlnkyv teknykkfly kpdvkelnie sdlrslelll 481 peddsskdyf pprkidesvs deefdsdmes qliideekel thlssnavds ddleeiawni 541 smwsilnyem dvhnkvngpl trsqygkrnp qgvlvdvvie rllhhtnsry mykrlnmkdd 601 dklefkfdfa fdscdeveem dlsclickvn krnivtwpcr clalcddcri slgykgfatc 661 vscdsevkgy sklniv // LOCUS NP_014391 352 aa linear PLN 30-JUN-2025 DEFINITION type II HSP40 co-chaperone SIS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014391 VERSION NP_014391.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182846.1 REFERENCE 1 (residues 1 to 352) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 352) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 352) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 352) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10536. Method: conceptual translation. FEATURES Location/Qualifiers source 1..352 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..352 /product="type II HSP40 co-chaperone SIS1" /calculated_mol_wt="37459" Region 8..350 /region_name="DnaJ_bact" /note="chaperone protein DnaJ; TIGR02349" /db_xref="CDD:274090" CDS 1..352 /gene="SIS1" /locus_tag="YNL007C" /coded_by="NM_001182846.1:1..1059" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22718905]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:33326013]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:33293525]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:9774392]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:8513501]" /experiment="EXISTENCE:direct assay:GO:0051787 misfolded protein binding [PMID:33293525|PMID:23791384]" /experiment="EXISTENCE:mutant phenotype:GO:0002236 detection of misfolded protein [PMID:33293525]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:8513501]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:14657253]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:25853343]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:33293525]" /experiment="EXISTENCE:mutant phenotype:GO:0035719 tRNA import into nucleus [PMID:25853343]" /experiment="EXISTENCE:mutant phenotype:GO:0070843 misfolded protein transport [PMID:23791384]" /experiment="EXISTENCE:mutant phenotype:GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system [PMID:23791384]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:32118579]" /note="Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1" /db_xref="GeneID:855725" /db_xref="SGD:S000004952" ORIGIN 1 mvketklydl lgvspsaneq elkkgyrkaa lkyhpdkptg dtekfkeise afeilndpqk 61 reiydqygle aarsggpsfg pggpggagga ggfpggaggf sgghafsned afnifsqffg 121 gsspfggadd sgfsfssyps gggagmggmp ggmggmhggm ggmpggfrsa sssptypeee 181 tvqvnlpvsl edlfvgkkks fkigrkgphg asektqidiq lkpgwkagtk ityknqgdyn 241 pqtgrrktlq fviqekshpn fkrdgddliy tlplsfkesl lgfsktiqti dgrtlplsrv 301 qpvqpsqtst ypgqgmptpk npsqrgnliv kykvdypisl ndaqkraide nf // LOCUS NP_014392 303 aa linear PLN 30-JUN-2025 DEFINITION TOR complex subunit LST8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014392 VERSION NP_014392.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182845.3 REFERENCE 1 (residues 1 to 303) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 303) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 303) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 303) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10537. On Jul 30, 2012 this sequence version replaced NP_014392.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..303 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..303 /product="TOR complex subunit LST8" /calculated_mol_wt="33903" Region <4..281 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 36..73 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 78..114 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 120..155 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 162..204 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 210..247 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 253..277 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..303 /gene="LST8" /locus_tag="YNL006W" /coded_by="NM_001182845.3:1..912" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:12719473]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:12719473]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:12719473]" /experiment="EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:12719473]" /experiment="EXISTENCE:mutant phenotype:GO:0031929 TOR signaling [PMID:12719473]" /experiment="EXISTENCE:mutant phenotype:GO:0031930 mitochondria-nucleus signaling pathway [PMID:11742997]" /experiment="EXISTENCE:mutant phenotype:GO:0043539 protein serine/threonine kinase activator activity [PMID:16002396]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]" /note="Subunit of TORC1 and TORC2 involved in TOR signaling; TORC1 regulates nutrient responsive growth and TORC2 regulates plasma membrane (PM) homeostasis and cell-cycle dependent actin cytoskeleton polarization; negative regulator of Rtg1p/3p and Gln3p transcription factors and amino acid biosynthesis; binds to both Tor1p and Tor2p, regulating the integrity and kinase activity of TORC2; PM retention is dependent on Avo3p; WD-repeat protein" /db_xref="GeneID:855726" /db_xref="SGD:S000004951" ORIGIN 1 msvilvsagy dhtirfweal tgvcsrtiqh sdsqvnrlei tndkkllata ghqnvrlydi 61 rttnpnpvas feghrgnvts vsfqqdnrwm vtssedgtik vwdvrspsip rnykhnapvn 121 evvihpnqge liscdrdgni riwdlgenqc thqltpeddt slqslsmasd gsmlaaantk 181 gncyvwempn htdashlkpv tkfrahstyi trillssdvk hlatcsadht arvwsidddf 241 klettldghq rwvwdcafsa dsaylvtass dhyvrlwdls treivrqygg hhkgavcval 301 ndv // LOCUS NP_014393 371 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL27m MRP7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014393 VERSION NP_014393.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182844.1 REFERENCE 1 (residues 1 to 371) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 371) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 371) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 371) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10538. Method: conceptual translation. FEATURES Location/Qualifiers source 1..371 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..371 /product="mitochondrial 54S ribosomal protein bL27m MRP7" /calculated_mol_wt="43096" Region 27..110 /region_name="L27" /note="ribosomal protein L27; TIGR00062" /db_xref="CDD:272882" Region 135..371 /region_name="Ribosomal_L27_C" /note="Ribosomal L27 protein C-terminal domain; pfam18471" /db_xref="CDD:408264" CDS 1..371 /gene="MRP7" /locus_tag="YNL005C" /gene_synonym="bL27m" /coded_by="NM_001182844.1:1..1116" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:28931599]" /note="Mitochondrial ribosomal protein of the large subunit; involved together with Mrpl35p in assembly of cytochrome c oxidase" /db_xref="GeneID:855727" /db_xref="SGD:S000004950" ORIGIN 1 mwnpilldts sfsfqkhvsg vflqvrnatk raagsrtsmk dsagrrlgpk kyegqdvstg 61 eiimrqrgtk fypgenvgig kdhsifalep gvvryyldpf hpkrkfigva lrrdlklpsp 121 hfeptvrrfg rfeltnkraa ykeensisrk dylakpnilk qlevreskrk elqdklskvl 181 rdelkldikd ielatsylir vraslkngyp iedarfnsry ylkeeerlka rreswtnekl 241 seslskidec sdllnsstsf nnklelhqyi seqekqalka klledleksq hletkkdkny 301 ikalfkdacn fltlseevhl rrkylksvfp etdstvetks gkksivsrrf dytknkvevi 361 arsrraflsk l // LOCUS NP_014394 454 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_014394 VERSION NP_014394.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182843.1 REFERENCE 1 (residues 1 to 454) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 454) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 454) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 454) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10539. On Jul 30, 2007 this sequence version replaced NP_014394.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..454 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..454 /product="mRNA-binding protein" /calculated_mol_wt="52011" Region <29..>85 /region_name="PRK12678" /note="transcription termination factor Rho; Provisional" /db_xref="CDD:237171" Region 160..236 /region_name="RRM1_HRB1_GBP2" /note="RNA recognition motif 1 (RRM1) found in Saccharomyces cerevisiae protein HRB1, G-strand-binding protein 2 (GBP2) and similar proteins; cd21605" /db_xref="CDD:410184" Region 262..334 /region_name="RRM2_HRB1_GBP2" /note="RNA recognition motif 2 (RRM2) found in Saccharomyces cerevisiae protein HRB1, G-strand-binding protein 2 (GBP2) and similar proteins; cd21606" /db_xref="CDD:410185" Region 374..452 /region_name="RRM3_HRB1_GBP2" /note="RNA recognition motif 3 (RRM3) found in Saccharomyces cerevisiae protein HRB1, G-strand-binding protein 2 (GBP2) and similar proteins; cd21607" /db_xref="CDD:410186" CDS 1..454 /gene="HRB1" /locus_tag="YNL004W" /gene_synonym="TOM34" /coded_by="NM_001182843.1:1..1365" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:14769921]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:14676199]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:14769921|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9499403]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9499403]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:24452287]" /note="Poly(A+) RNA-binding guard protein; key surveillance factor for the selective export of spliced mRNAs from the nucleus to the cytoplasm; preference for intron-containing genes; similar to Npl3p; HRB1 has a paralog, GBP2, that arose from the whole genome duplication" /db_xref="GeneID:855728" /db_xref="SGD:S000004949" ORIGIN 1 msdqergsen nnrsrsrsrs pvrrrmsddh gyerdnhlsr rsgnyngrrk fadtyrgsrd 61 rgeyrggrer sdyrererfn nrdnprsrdr yddrrrgrdv tgrygnrrdd yprsfrsrhn 121 trddsrrggf gssgargdyg pllareldst yeekvnrnys nsifvgnlty dstpedltef 181 fsqigkvvra diitsrghhr gmgtveftns ddvdrairqy dgaffmdrki fvrqdnppps 241 nnikerkald rgelrhnrkt hevivknlpa svnwqalkdi fkecgnvaha dveldgdgvs 301 tgsgtvsfyd ikdlhraiek yngysiegnv ldvkskesvh nhsdgddvdi pmddspvnee 361 arkftenvvg ggernrliyc snlpfstaks dlydlfetig kvnnaelryd skgaptgiav 421 veydnvddad vcierlnnyn yggcdldisy akrl // LOCUS NP_014395 284 aa linear PLN 30-JUN-2025 DEFINITION Pet8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014395 VERSION NP_014395.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182842.3 REFERENCE 1 (residues 1 to 284) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 284) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 284) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 284) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10540. On Jul 30, 2012 this sequence version replaced NP_014395.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..284 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..284 /product="Pet8p" /calculated_mol_wt="30896" Region 5..263 /region_name="PTZ00168" /note="mitochondrial carrier protein; Provisional" /db_xref="CDD:185494" CDS 1..284 /gene="PET8" /locus_tag="YNL003C" /gene_synonym="SAM5" /coded_by="NM_001182842.3:1..855" /experiment="EXISTENCE:direct assay:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:14609944]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14609944|PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015805 S-adenosyl-L-methionine transport [PMID:14609944]" /experiment="EXISTENCE:genetic interaction:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:14609944]" /experiment="EXISTENCE:genetic interaction:GO:0015805 S-adenosyl-L-methionine transport [PMID:14609944]" /experiment="EXISTENCE:mutant phenotype:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:14609944]" /experiment="EXISTENCE:mutant phenotype:GO:0015805 S-adenosyl-L-methionine transport [PMID:14609944]" /note="S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth" /db_xref="GeneID:855729" /db_xref="SGD:S000004948" ORIGIN 1 mntfflslls gaaagtstdl vffpidtikt rlqakggffa nggykgiyrg lgsavvasap 61 gaslffisyd ymkvksrpyi sklysqgseq lidttthmls ssigeicacl vrvpaevvkq 121 rtqvhstnss wqtlqsilrn dnkeglrknl yrgwsttimr eipftciqfp lyeylkktwa 181 kangqsqvep wkgaicgsia ggiaaatttp ldflktrlml nkttaslgsv iiriyreegp 241 avffsgvgpr tmwisaggai flgmyetvhs llsksfptag emra // LOCUS NP_014396 322 aa linear PLN 30-JUN-2025 DEFINITION Rlp7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014396 VERSION NP_014396.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182841.3 REFERENCE 1 (residues 1 to 322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 322) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10541. On Jul 30, 2012 this sequence version replaced NP_014396.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..322 /product="Rlp7p" /calculated_mol_wt="36428" Region 141..322 /region_name="Ribosomal_L7_archeal_euk" /note="Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome. The...; cd01657" /db_xref="CDD:100099" Site order(147..149,157..159,161..162,164..167,169..173, 181..186,188..189,191..193,211,272..279,302..303,307,322) /site_type="other" /note="23S rRNA binding site [nucleotide binding]" /db_xref="CDD:100099" Site order(188..189,191..193,301..304) /site_type="other" /note="5S rRNA binding site [nucleotide binding]" /db_xref="CDD:100099" CDS 1..322 /gene="RLP7" /locus_tag="YNL002C" /gene_synonym="RPL7" /coded_by="NM_001182841.3:1..969" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11087857]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:11583614]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:24129494]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:23945946]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11087857]" /experiment="EXISTENCE:mutant phenotype:GO:0000465 exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11087857]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11087857]" /note="Nucleolar protein similar to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs; binds junction of ITS2 and ITS2-proximal stem between the 3' end of 5.8S rRNA and the 5' end of 25S rRNA" /db_xref="GeneID:855730" /db_xref="SGD:S000004947" ORIGIN 1 msstqdskaq tlnsnpeill rkrrnadrtr ierqelakkk reeqikkkrs nknkfvraes 61 ivaktlatsr ekerikrvsi ledkkaknet qhiasgkdfi lkitekanga eensvdleet 121 eeeeddglir ekttydgkpa llfivrvrgp lavnipnkaf kilsllrlve tntgvfvklt 181 knvypllkvi apyvvigkps lssirsliqk rgriiykgen eaepheivln dnniveeqlg 241 dhgiicvedi iheiatmges fsvcnfflqp fklnrevsgf gslnrlrkik qreaesrtrq 301 fsnaatapvi evdidsllak ln // LOCUS NP_014397 386 aa linear PLN 30-JUN-2025 DEFINITION ribosome dissociation factor DOM34 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014397 VERSION NP_014397.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001182840.1 REFERENCE 1 (residues 1 to 386) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 386) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 386) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 386) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 386) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10542. Method: conceptual translation. FEATURES Location/Qualifiers source 1..386 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..386 /product="ribosome dissociation factor DOM34" /calculated_mol_wt="43927" Region 4..376 /region_name="pelota" /note="mRNA surveillance protein pelota; TIGR00111" /db_xref="CDD:129217" CDS 1..386 /gene="DOM34" /locus_tag="YNL001W" /coded_by="NM_001182840.1:1..1161" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:17889667]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032790 ribosome disassembly [PMID:20947765|PMID:24424461]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:21623367]" /experiment="EXISTENCE:direct assay:GO:1990533 Dom34-Hbs1 complex [PMID:21623367]" /experiment="EXISTENCE:genetic interaction:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:16554824]" /experiment="EXISTENCE:mutant phenotype:GO:0032790 ribosome disassembly [PMID:24424461|PMID:22770215]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:24424461]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]" /experiment="EXISTENCE:mutant phenotype:GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay [PMID:19420139]" /note="Protein that facilitates ribosomal subunit dissociation; Dom34-Hbs1 complex and Rli1p have roles in dissociating inactive ribosomes to facilitate translation restart, particularly ribosomes stalled in 3' UTRs; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication" /db_xref="GeneID:855731" /db_xref="SGD:S000004946" ORIGIN 1 mkvislkkds fnkggavitl lpedkedlft vyqivdkdde lifkkkftsk ldeagkkkst 61 dlvklkikvi sedfdmkdey lkykgvtvtd esgasnvdip vgkylsftld yvypftiikq 121 nfnkfmqkll neacnieyks dtaavvlqeg iahvclvtss stilkqkiey smpkkkrttd 181 vlkfdektek fykaiysamk kdlnfdklkt iilcspgfya kilmdkifqy aeeehnkkil 241 dnkgmffiah cstgylqgin evlknplyas klqdtkyske imvmdefllh lnkdddkawy 301 gekevvkaae ygaisylllt dkvlhsdnia qreeylklmd svesnggkal vlstlhslge 361 eldqltgiac ilkyplpdld eddgee // LOCUS NP_014398 479 aa linear PLN 30-JUN-2025 DEFINITION citrate (Si)-synthase CIT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014398 VERSION NP_014398.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183178.1 REFERENCE 1 (residues 1 to 479) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 479) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 479) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 479) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10543. Method: conceptual translation. FEATURES Location/Qualifiers source 1..479 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..479 /product="citrate (Si)-synthase CIT1" /EC_number="2.3.3.1" /calculated_mol_wt="53229" Region 45..471 /region_name="ScCit1-2_like" /note="Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; cd06105" /db_xref="CDD:99858" Site order(83..84,87..93,178,182,185,276,281,284..285,288..289, 292..294,298,305..306,309..311,359,456..464) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:99858" Site order(85,276,280,310..313,315,318,352..359,362,367,408,411, 413,435,439,456,459) /site_type="active" /db_xref="CDD:99858" Site order(85,310..312,315,318,352..359,362,408,411,413,456) /site_type="other" /note="coenzyme A binding site [chemical binding]" /db_xref="CDD:99858" Site order(85,276,280,311..312,352..353,355..359,367,411,439) /site_type="other" /note="citrylCoA binding site [chemical binding]" /db_xref="CDD:99858" Site order(276,280,312..313,358..359,367,413,435,439,459) /site_type="other" /note="oxalacetate/citrate binding site [chemical binding]" /db_xref="CDD:99858" Site order(312,358,413) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:99858" CDS 1..479 /gene="CIT1" /locus_tag="YNR001C" /gene_synonym="LYS6" /coded_by="NM_001183178.1:1..1440" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:24769239|PMID:14576278|PMID:11914276|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0036440 citrate synthase activity [PMID:17570335]" /experiment="EXISTENCE:direct assay:GO:0046356 acetyl-CoA catabolic process [PMID:17570335]" /experiment="EXISTENCE:genetic interaction:GO:0006101 citrate metabolic process [PMID:12913175]" /experiment="EXISTENCE:mutant phenotype:GO:0036440 citrate synthase activity [PMID:17570335]" /experiment="EXISTENCE:mutant phenotype:GO:0046356 acetyl-CoA catabolic process [PMID:17570335]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="Mitochondrial citrate synthase; catalyzes condensation of acetyl coenzyme A and oxaloacetate to form citrate, which is the first and rate-limiting step of the TCA cycle; transcription subject to glucose repression; CIT1 has a paralog, CIT2, that arose from the whole genome duplication" /db_xref="GeneID:855732" /db_xref="SGD:S000005284" ORIGIN 1 msailsttsk sflsrgstrq cqnmqkalfa llnarhyssa seqtlkerfa eiipakaeei 61 kkfkkehgkt vigevlleqa yggmrgikgl vwegsvldpe egirfrgrti peiqrelpka 121 egsteplpea lfwllltgei ptdaqvkals adlaarseip ehviqlldsl pkdlhpmaqf 181 siavtalese skfakayaqg vskkeywsyt fedsldllgk lpviaskiyr nvfkdgkits 241 tdpnadygkn laqllgyenk dfidlmrlyl tihsdheggn vsahtthlvg salsspylsl 301 aaglnglagp lhgranqevl ewlfklreev kgdysketie kylwdtlnag rvvpgyghav 361 lrktdpryta qrefalkhfp dyelfklvst iyevapgvlt khgktknpwp nvdshsgvll 421 qyyglteasf ytvlfgvara igvlpqliid ravgapierp ksfstekyke lvkkieskn // LOCUS NP_014399 282 aa linear PLN 30-JUN-2025 DEFINITION putative ammonium permease ATO2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014399 VERSION NP_014399.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183179.3 REFERENCE 1 (residues 1 to 282) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 282) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 282) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 282) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10544. On Jul 30, 2012 this sequence version replaced NP_014399.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..282 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..282 /product="putative ammonium permease ATO2" /calculated_mol_wt="30570" Region 70..275 /region_name="Gpr1_Fun34_YaaH" /note="GPR1/FUN34/yaaH family; pfam01184" /db_xref="CDD:426106" CDS 1..282 /gene="ATO2" /locus_tag="YNR002C" /gene_synonym="FUN34" /coded_by="NM_001183179.3:1..849" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17395151]" /experiment="EXISTENCE:mutant phenotype:GO:0008519 ammonium channel activity [PMID:12429834]" /experiment="EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:12429834]" /experiment="EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:12429834]" /note="Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication" /db_xref="GeneID:855736" /db_xref="SGD:S000005285" ORIGIN 1 msdreqssgn tafenpkald ssegefisen ndqsrhsqes ickiytagkn neyiyigrqk 61 flrddlfeaf ggtlnpglap apvhkfanpa plglsgfalt tfvlsmfnar aqgitipnvv 121 vgcamfyggl vqliagiwei alentfggta lcsfggfwls fgaiyipwfg ildaykdkes 181 dlgnalgfyl lgwalftfgl svctmkstim ffalffllav tflllsianf tgevgvtrag 241 gvlgvivafi awynayagia trqnsyimvh pfalpsndkv ff // LOCUS NP_014400 317 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase III subunit C34 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014400 VERSION NP_014400.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183180.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10545. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..317 /product="DNA-directed RNA polymerase III subunit C34" /calculated_mol_wt="36004" Region 4..317 /region_name="RPC34" /note="DNA-directed RNA polymerase III, subunit C34 [Transcription]; COG5111" /db_xref="CDD:227442" CDS 1..317 /gene="RPC34" /locus_tag="YNR003C" /coded_by="NM_001183180.1:1..954" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:1400451]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex" /db_xref="GeneID:855737" /db_xref="SGD:S000005286" ORIGIN 1 msgmienglq lsdnaktlhs qmmskgigal ftqqelqkqm gigsltdlms ivqelldknl 61 iklvkqndel kfqgvlesea qkkatmsaee alvysyieas gregiwskti kartnlhqhv 121 vlkclksles qryvksvksv kfptrkiyml yslqpsvdit ggpwftdgel diefinsllt 181 ivwrfisent fpngfknfen gpkknvfyap nvknysttqe ilefitaaqv anveltpsni 241 rslcevlvyd dklekvthdc yrvtlesilq mnqgegepea gnkaledeee fsifnyfkmf 301 paskhdkevv yfdewti // LOCUS NP_014401 146 aa linear PLN 30-JUN-2025 DEFINITION Swm2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014401 VERSION NP_014401.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183181.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10546. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..146 /product="Swm2p" /calculated_mol_wt="16965" Region 14..144 /region_name="Swm2" /note="Nucleolar protein Swm2; pfam17083" /db_xref="CDD:407235" CDS 1..146 /gene="SWM2" /locus_tag="YNR004W" /coded_by="NM_001183181.1:1..441" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:27348091]" /experiment="EXISTENCE:mutant phenotype:GO:0036261 7-methylguanosine cap hypermethylation [PMID:20621096]" /note="Protein with a role in snRNA and snoRNA cap trimethylation; interacts with Tgs1p and shows similar phenotypes; required for trimethylation of the caps of spliceosomal snRNAs and the U3 snoRNA, and for efficient 3' end processing of U3 snoRNA; may act as a specificity factor for Tgs1p" /db_xref="GeneID:855738" /db_xref="SGD:S000005287" ORIGIN 1 midlynysnl eglldgltdl nripkeysav lepyfqniar nahlksralk icrsnfhkwn 61 eegaktvnpe iirrclnlwy vlkgkeykkl kdpppadnii kdeidvsyvk nlnvvrlefd 121 efgklisnpl enlileevev ndfiqe // LOCUS NP_014403 622 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-0 subunit protein VPS27 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014403 VERSION NP_014403.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183183.3 REFERENCE 1 (residues 1 to 622) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 622) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 622) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 622) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10547. On Jul 30, 2012 this sequence version replaced NP_014403.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..622 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..622 /product="ESCRT-0 subunit protein VPS27" /calculated_mol_wt="70843" Region 7..149 /region_name="VHS_Vps27" /note="VHS (Vps27/Hrs/STAM) domain of Vacuolar protein sorting-associated protein 27; cd16979" /db_xref="CDD:340776" Site order(28..29,32,36,78..79) /site_type="other" /note="putative intraprotein/interprotein binding site [polypeptide binding]" /db_xref="CDD:340776" Region 169..226 /region_name="FYVE_like_SF" /note="FYVE domain like superfamily; cl28890" /db_xref="CDD:333710" Site order(188..193,198,220) /site_type="other" /note="phosphatidylinositol 3-phosphate binding site [chemical binding]" /db_xref="CDD:277249" Region 349..432 /region_name="GAT_Vps27" /note="non-canonical GAT domain found in fungal vacuolar protein sorting-associated protein 27 (Vps27) and similar proteins; cd21385" /db_xref="CDD:410590" Site order(350,355,358..359,361..362,365..366,368..369,371,374, 377..378,383,389..390,393,396..397,400,403..404,406..407, 409..410,413..414,416..421,423..424,427..428,430..431) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:410590" CDS 1..622 /gene="VPS27" /locus_tag="YNR006W" /gene_synonym="DID7; GRD11; SSV17; VPL23; VPT27" /coded_by="NM_001183183.3:1..1869" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:12055639]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:31740006]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:9702203]" /experiment="EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12055639|PMID:20150893]" /experiment="EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12055639]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:32726584]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:31740006]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:12055639]" /experiment="EXISTENCE:mutant phenotype:GO:0140504 microlipophagy [PMID:32726584]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0006623 protein targeting to vacuole [PMID:12055639]" /experiment="EXISTENCE:physical interaction:GO:0033565 ESCRT-0 complex [PMID:12055639]" /note="Ubiquitin binding protein involved in endosomal protein sorting; K48-, K63-Ub chain binding protein that preferentially binds K63-linked chains in vitro; subunit of the ESCRT-0 complex that binds to ubiquitin via two ubiquitin-interacting motifs (UIMs) and is involved in sorting cargo into multivesicular bodies; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation" /db_xref="GeneID:855739" /db_xref="SGD:S000005289" ORIGIN 1 msvstpseld alieqatses ipngdldlpi aleisdvlrs rrvnpkdsmr cikkrilnta 61 dnpntqlssw kltnicvkng gtpfikeics refmdtmehv ilredsneel selvktilye 121 lyvafkndsq lnyvakvydk lisrgikfpe kltlsnspta mfdsktpadw idsdacmics 181 kkfsllnrkh hcrscggvfc qehssnsipl pdlgiyepvr vcdscfedyd lkrhddskks 241 kkhrhkrkkd rdystpedee elirkaiels lkesrnsass epivpvvesk nevkrqeiee 301 eedpdlkaai qeslreaeea klrserqkas rqmqpqqpsp qpqpihsvdl sdeekdsiym 361 faslvekmks rplneileds klqnlaqrvf askarlnyal ndkaqkyntl iemngkisei 421 mniydrlleq qlqsinlsqq ytlpqvpsdp ynyltenvqn paesyqtppl qqlsshqykp 481 qqdvsrqqsv kansspttni dhlktidvtp haqqkpqshv elapsdppyp keeaedegtq 541 avqdeesstq esrerpypve tengetsink rpqgitrydf ptvparkfvq pestvplpas 601 sseipikeer ppspqeelli el // LOCUS NP_014404 310 aa linear PLN 30-JUN-2025 DEFINITION Atg3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014404 VERSION NP_014404.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183184.3 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10548. On Jul 30, 2012 this sequence version replaced NP_014404.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..310 /product="Atg3p" /calculated_mol_wt="35756" Region 32..305 /region_name="Autophagy_act_C" /note="Autophagocytosis associated protein, active-site domain; pfam03987" /db_xref="CDD:461120" CDS 1..310 /gene="ATG3" /locus_tag="YNR007C" /gene_synonym="APG3; AUT1" /coded_by="NM_001183184.3:1..933" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:25680528|PMID:25645919]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006501 C-terminal protein lipidation [PMID:15277523]" /experiment="EXISTENCE:direct assay:GO:0061908 phagophore [PMID:25680528|PMID:25645919]" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:25680528]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006501 C-terminal protein lipidation [PMID:15277523|PMID:11100732]" /experiment="EXISTENCE:mutant phenotype:GO:0019776 Atg8-family ligase activity [PMID:11100732]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:9023185]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0061908 phagophore [PMID:25680528]" /note="E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p regulated by acetylation by NuA4 histone acetyltransferase Esa1p while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; Atg12p-Atg5p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site" /db_xref="GeneID:855741" /db_xref="SGD:S000005290" ORIGIN 1 mirstlsswr eyltpithks tflttgqitp eefvqagdyl chmfptwkwn eessdisyrd 61 flpknkqfli irkvpcdkra eqcvevegpd vimkgfaedg deddvleyig setehvqstp 121 aggtkdssid dideliqdme ikeedenddt eefnakggla kdmaqeryyd lyiaystsyr 181 vpkmyivgfn sngsplspeq mfedisadyr tktatieklp fyknsvlsvs ihpckhanvm 241 killdkvrvv rqrrrkelqe eqeldgvgdw edlqddidds lrvdqylivf lkfitsvtps 301 iqhdytmegw // LOCUS NP_014405 661 aa linear PLN 30-JUN-2025 DEFINITION phospholipid:diacylglycerol acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014405 VERSION NP_014405.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183185.1 REFERENCE 1 (residues 1 to 661) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 661) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 661) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 661) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10549. Method: conceptual translation. FEATURES Location/Qualifiers source 1..661 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..661 /product="phospholipid:diacylglycerol acyltransferase" /EC_number="2.3.1.158" /calculated_mol_wt="75262" Region <2..>79 /region_name="EIF4E-T" /note="Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E; pfam10477" /db_xref="CDD:371079" Region 206..625 /region_name="LCAT" /note="Lecithin:cholesterol acyltransferase; pfam02450" /db_xref="CDD:396835" CDS 1..661 /gene="LRO1" /locus_tag="YNR008W" /coded_by="NM_001183185.1:1..1986" /experiment="EXISTENCE:direct assay:GO:0005637 nuclear inner membrane [PMID:31422915]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:22454508]" /experiment="EXISTENCE:direct assay:GO:0006672 ceramide metabolic process [PMID:22738231]" /experiment="EXISTENCE:direct assay:GO:0019432 triglyceride biosynthetic process [PMID:10747858]" /experiment="EXISTENCE:direct assay:GO:0019915 lipid storage [PMID:10747858]" /experiment="EXISTENCE:direct assay:GO:0046027 phospholipid:diacylglycerol acyltransferase activity [PMID:10747858]" /experiment="EXISTENCE:direct assay:GO:0055091 phospholipid homeostasis [PMID:31422915]" /experiment="EXISTENCE:direct assay:GO:0097038 perinuclear endoplasmic reticulum [PMID:22454508]" /experiment="EXISTENCE:mutant phenotype:GO:0006672 ceramide metabolic process [PMID:22738231]" /experiment="EXISTENCE:mutant phenotype:GO:0019432 triglyceride biosynthetic process [PMID:10747858]" /experiment="EXISTENCE:mutant phenotype:GO:0019915 lipid storage [PMID:10747858]" /note="Acyltransferase that converts diacylglycerol to triacylglycerol (TGA); one of several acyltransferases that contribute to TGA synthesis; relocates from ER to nuclear membrane in response cell cycle and starvation signals; Lro1p and Dga1p can O-acylate ceramides; putative homolog of human lecithin cholesterol acyltransferase" /db_xref="GeneID:855742" /db_xref="SGD:S000005291" ORIGIN 1 mgtlfrrnvq nqksdsdenn kggsvhnkre srnhihhqqg lghkrrrgis gsakrnergk 61 dfdrkrdgng rkrwrdsrrl ifilgaflgv llpfsfgayh vhnsdsdlfd nfvnfdslkv 121 ylddwkdvlp qgissfiddi qagnystssl ddlsenfavg kqllrdynie akhpvvmvpg 181 vistgieswg vigddecdss ahfrkrlwgs fymlrtmvmd kvcwlkhvml dpetgldppn 241 ftlraaqgfe stdyfiagyw iwnkvfqnlg vigyepnkmt saaydwrlay ldlerrdryf 301 tklkeqielf hqlsgekvcl ighsmgsqii fyfmkwveae gplygnggrg wvnehidsfi 361 naagtllgap kavpalisge mkdtiqlntl amyglekffs riervkmlqt wggipsmlpk 421 geeviwgdmk sssedalnnn tdtygnfirf erntsdafnk nltmkdainm tlsispewlq 481 rrvheqysfg yskneeelrk nelhhkhwsn pmevplpeap hmkiyciygv nnpterayvy 541 keeddssaln ltidyeskqp vfltegdgtv plvahsmchk waqgaspynp aginvtivem 601 khqpdrfdir ggaksaehvd ilgsaelndy ilkiasgngd lveprqlsnl sqwvsqmpfp 661 m // LOCUS NP_014406 249 aa linear PLN 30-JUN-2025 DEFINITION Nrm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014406 VERSION NP_014406.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183186.1 REFERENCE 1 (residues 1 to 249) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 249) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 249) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 249) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10550. Method: conceptual translation. FEATURES Location/Qualifiers source 1..249 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..249 /product="Nrm1p" /calculated_mol_wt="27433" Region 103..127 /region_name="Whi5" /note="Whi5 like; pfam08528" /db_xref="CDD:462511" CDS 1..249 /gene="NRM1" /locus_tag="YNR009W" /coded_by="NM_001183186.1:1..750" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030907 MBF transcription complex [PMID:16916637]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:16916637]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16916637]" /experiment="EXISTENCE:physical interaction:GO:0140297 DNA-binding transcription factor binding [PMID:16916637]" /note="Transcriptional co-repressor of MBF-regulated gene expression; Nrm1p associates stably with promoters via MCB binding factor (MBF) to repress transcription upon exit from G1 phase" /db_xref="GeneID:855743" /db_xref="SGD:S000005292" ORIGIN 1 msimkqrlpl gefssskink laianiadas eprnhgennv gtvclpsiks lmvspevyen 61 tkslpvplmr ssgggmacas ksscqdgist kttsrdysel skklqirlqf ayykyktkqt 121 dknftdlksk hsitrpskva thsksepltr rrklvlsqgh yktparskik tpssicshdn 181 tssftsfrgv sesssttadm nvadtttpir nnintkhsns hnrtlyqrqe tptsikaaks 241 lihlftsnq // LOCUS NP_014407 149 aa linear PLN 30-JUN-2025 DEFINITION Cse2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014407 VERSION NP_014407.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183187.3 REFERENCE 1 (residues 1 to 149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 149) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10551. On Jul 30, 2012 this sequence version replaced NP_014407.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..149 /product="Cse2p" /calculated_mol_wt="17245" Region 68..149 /region_name="Med9-C" /note="Mediator complex subunit 9 (Med9) C-terminal domain family; cd21431" /db_xref="CDD:467847" Site order(69,72,76,79..80,83,98..99,102,106,117,121..123, 125..126,129..130,132..133,135..136,139..140) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467847" CDS 1..149 /gene="CSE2" /locus_tag="YNR010W" /gene_synonym="MED9" /coded_by="NM_001183187.3:1..450" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:19077037]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:19077037]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9812975]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11470794]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:19077037]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9891034]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:855744" /db_xref="SGD:S000005293" ORIGIN 1 mnlqnnvlnq ihqillptnp tldkpnaeat keefssaenr dekdyltnqq pknlstpsts 61 sngefiphif yslhqirkdp nnlsnqletl tgsirhrlkl ckslisened tkdllsksps 121 ewqdiihqre qelqikrdvl ddlyrklqr // LOCUS NP_014408 876 aa linear PLN 30-JUN-2025 DEFINITION DEAH-box RNA-dependent ATPase PRP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014408 VERSION NP_014408.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183188.1 REFERENCE 1 (residues 1 to 876) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 876) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 876) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 876) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 876) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10552. Method: conceptual translation. FEATURES Location/Qualifiers source 1..876 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..876 /product="DEAH-box RNA-dependent ATPase PRP2" /EC_number="3.6.4.13" /calculated_mol_wt="99683" Region <7..174 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" Region 223..>738 /region_name="HrpA" /note="HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; COG1643" /db_xref="CDD:441249" Region 775..862 /region_name="OB_NTP_bind" /note="Oligonucleotide/oligosaccharide-binding (OB)-fold; pfam07717" /db_xref="CDD:400182" CDS 1..876 /gene="PRP2" /locus_tag="YNR011C" /gene_synonym="RNA2" /coded_by="NM_001183188.1:1..2631" /experiment="EXISTENCE:direct assay:GO:0000349 generation of catalytic spliceosome for first transesterification step [PMID:8943336]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:1534753]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:2251118]" /experiment="EXISTENCE:mutant phenotype:GO:0034247 snoRNA splicing [PMID:24442613]" /note="RNA-dependent DExH-box ATPase/helicase; required for activation of spliceosome before first transesterification step in RNA splicing; implicated in rearranging and proofreading snRNA structure in catalytic activation of spliceosome; ortholog of human protein DHX16" /db_xref="GeneID:855745" /db_xref="SGD:S000005294" ORIGIN 1 mssitsetgk rrvkrtyevt rqndnavrie psslgeeedk eakdknsalq lkrsrydpnk 61 vfsntnqgpe knnlkgeqlg sqkksskyde kitsnneltt kkgllgdsen etkyassnsk 121 fnvevthkik nakeidkinr qrmweeqqlr namagqsdhp dditlegsdk ydyvfdtdam 181 idytneeddl lpeeklqyea rlaqaletee kriltiqear kllpvhqykd ellqeikknq 241 vliimgetgs gkttqlpqyl vedgftdqgk lqiaitqprr vaatsvaarv ademnvvlgk 301 evgyqirfed kttpnktvlk ymtdgmllre fltdsklsky scimideahe rtlatdilig 361 llkdilpqrp tlkllissat mnakkfseff dncpifnvpg rrypvdihyt lqpeanyiha 421 aittifqiht tqslpgdilv fltgqeeier tktkleeims klgsrtkqmi itpiyanlpq 481 eqqlkifqpt pencrkvvla tniaetslti dgiryvidpg fvkensyvps tgmtqlltvp 541 csrasvdqra gragrvgpgk cfriftkwsy lhelelmpkp eitrtnlsnt vllllslgvt 601 dlikfplmdk psiptlrksl enlyilgaln skgtitrlgk mmcefpcepe fakvlytaat 661 heqcqgvlee cltivsmlhe tpslfigqkr daaasvlsev esdhilylei fnqwrnskfs 721 rswcqdhkiq fktmlrvrni rnqlfrcsek vglvekndqa rmkigniagy inaritrcfi 781 sgfpmnivql gptgyqtmgr ssgglnvsvh ptsilfvnhk ekaqrpskyv lyqqlmltsk 841 efirdclvip keewlidmvp qifkdliddk tnrgrr // LOCUS NP_014409 501 aa linear PLN 30-JUN-2025 DEFINITION uridine kinase URK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014409 VERSION NP_014409.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183189.1 REFERENCE 1 (residues 1 to 501) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 501) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 501) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 501) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10553. Method: conceptual translation. FEATURES Location/Qualifiers source 1..501 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..501 /product="uridine kinase URK1" /EC_number="2.7.1.48" /calculated_mol_wt="56165" Region 69..260 /region_name="udk" /note="uridine kinase; TIGR00235" /db_xref="CDD:272977" Site order(70,195,243) /site_type="other" /note="ATP-binding site [chemical binding]" /db_xref="CDD:238981" Site order(91,113,196) /site_type="active" /note="Sugar specificity [active]" /db_xref="CDD:238981" Site order(94,110,141,143,146,204) /site_type="active" /note="Pyrimidine base specificity [active]" /db_xref="CDD:238981" Region 292..474 /region_name="PRTases_typeI" /note="Phosphoribosyl transferase (PRT)-type I domain; cl00309" /db_xref="CDD:444823" CDS 1..501 /gene="URK1" /locus_tag="YNR012W" /coded_by="NM_001183189.1:1..1506" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004849 uridine kinase activity [PMID:10501935]" /experiment="EXISTENCE:mutant phenotype:GO:0008655 pyrimidine-containing compound salvage [PMID:11872485]" /note="Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP" /db_xref="GeneID:855746" /db_xref="SGD:S000005295" ORIGIN 1 mshriapske rsssfisild detrdtlkan avmdgevdvk ktkgkssryi ppwttpyiig 61 iggasgsgkt svaakivssi nvpwtvlisl dnfynplgpe drarafkney dfdepnainl 121 dlaykcilnl kegkrtnipv ysfvhhnrvp dkniviygas vvviegiyal ydrrlldlmd 181 lkiyvdadld vclarrlsrd ivsrgrdldg ciqqwekfvk pnavkfvkpt mknadaiips 241 msdnatavnl iinhikskle lksnehlrel iklgsspsqd vlnrniihel pptnqvlslh 301 tmllnknlnc adfvfyfdrl atillswald dipvahtnii tpgehtmenv iacqfdqvta 361 vniirsgdcf mkslrktipn itigklliqs dsqtgepqlh ceflppniek fgkvflmegq 421 iisgaamima iqvlldhgid lekisvvvyl atevgirril nafdnkvnif agmiisrekl 481 qnhqykwalt rffdskyfgc d // LOCUS NP_014410 894 aa linear PLN 30-JUN-2025 DEFINITION Pho91p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014410 VERSION NP_014410.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183190.3 REFERENCE 1 (residues 1 to 894) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 894) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 894) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 894) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10554. On Jul 30, 2012 this sequence version replaced NP_014410.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..894 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..894 /product="Pho91p" /calculated_mol_wt="99360" Region 1..262 /region_name="COG5408" /note="SPX domain-containing protein [Signal transduction mechanisms]" /db_xref="CDD:227695" Region 460..889 /region_name="SLC13_permease" /note="Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; cd01115" /db_xref="CDD:238535" Site order(467..470,477..490,518..535,559..575,577..594,598, 602..624,646..660,689..701,709..723,738..756,781..796, 816..835,871..883) /site_type="other" /note="transmembrane helices" /db_xref="CDD:238535" CDS 1..894 /gene="PHO91" /locus_tag="YNR013C" /coded_by="NM_001183190.3:1..2685" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:17804816]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:genetic interaction:GO:0005315 phosphate transmembrane transporter activity [PMID:11779791]" /experiment="EXISTENCE:genetic interaction:GO:0006817 phosphate ion transport [PMID:11779791]" /experiment="EXISTENCE:genetic interaction:GO:0015169 glycerol-3-phosphate transmembrane transporter activity [PMID:20133652]" /experiment="EXISTENCE:genetic interaction:GO:0015794 glycerol-3-phosphate transmembrane transport [PMID:20133652]" /experiment="EXISTENCE:genetic interaction:GO:2000185 regulation of phosphate transmembrane transport [PMID:12821119]" /experiment="EXISTENCE:mutant phenotype:GO:0005315 phosphate transmembrane transporter activity [PMID:12581367]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:17804816]" /experiment="EXISTENCE:mutant phenotype:GO:0015169 glycerol-3-phosphate transmembrane transporter activity [PMID:20133652]" /experiment="EXISTENCE:mutant phenotype:GO:0015794 glycerol-3-phosphate transmembrane transport [PMID:20133652]" /note="Low-affinity vacuolar phosphate transporter; exports phosphate from vacuolar lumen to cytosol; regulates phosphate and polyphosphate metabolism; acts upstream of Pho81p in regulation of PHO pathway; localizes to sites of contact between vacuole and mitochondria (vCLAMPs); targeted to vacuole via AP-3 pathway; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth" /db_xref="GeneID:855747" /db_xref="SGD:S000005296" ORIGIN 1 mkfshslqfn svpewstkyl aysqlkkliy slqkdklysn nkhhvvephd andenlplla 61 daspddqfyi skfvaalnqe lkkidkfyis qetglianyn elkddvmele ntnkatqlfn 121 qqqqhqlqsv arnrksksqq rqrrfssvss tdsnpsltdm sidsapviht qvsnttnngn 181 smqnlasasv slsnsnpvyl spftqhrlsl kkrlisiytq lselkdfiel nqtgfskick 241 kfdkslntnl kqnylnyikf hshvfnpati nriqhhitet iltyaslnkg trrpsntfnl 301 dadrinnden ssgneededg nrqevldfqd aerelsshlr dhvvwerntv wkdmmnlerk 361 yqsaktdnkk fsklsssqlr pnanitesma mssggagiia pstdsltfre lmhlppkqwl 421 qfimgqtsll kfllitscfi alltfnltpf tqdslqkncf ailiyasllw atetiplfvt 481 slmipllivv fpvikdpits qpmsprdssq filstmwssv imlllggftl aaalskynia 541 kvlsthilas agtnphfill tnmfvalfvs mwvsnvaapv lcysivqpll rtlprncsya 601 kalilgiala sniggmsspi aspqnifsig imdpspswae wfmialpvcf icvmaiwvll 661 iitfppepnv kilqlhpsrd pftlkqwfvt lvciitivlw clsnqisgif gemgiisiip 721 ivvffgtgll tsddfnnfmw tivvlamggt tlgkavsssg llstmaqlik aqvehepifi 781 ivlifglvil vmatfvshtv aamiivplms eigsnlpsgd hsrlliviaa llcssamglp 841 tsgfpnvtai smidevgdry ltvgtfitrg vpasllsyaa ivtvgygilk vmgf // LOCUS NP_014411 212 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNR014W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014411 VERSION NP_014411.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183191.3 REFERENCE 1 (residues 1 to 212) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 212) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 212) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 212) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10555. On Jul 30, 2012 this sequence version replaced NP_014411.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..212 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..212 /product="uncharacterized protein" /calculated_mol_wt="22945" Region 9..208 /region_name="DUF4667" /note="Domain of unknown function (DUF4667); pfam15700" /db_xref="CDD:406191" CDS 1..212 /locus_tag="YNR014W" /coded_by="NM_001183191.3:1..639" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /note="hypothetical protein; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible; YNR014W has a paralog, YMR206W, that arose from the whole genome duplication" /db_xref="GeneID:855748" /db_xref="SGD:S000005297" ORIGIN 1 msstdikpca vnipvsahit fhyksiadrs ssrssssssc ssatskacsp rgssvglppa 61 lstdneivet vlnvsapvva dptrpslfks nytaasclts dptspsllps srrnsvlpas 121 dfhqcahhkn fqrrasepql psfdnrssse mkrsvsyaqh smmfpisdqq epqtsaspnd 181 hsdpscpcnr hhhrrnsvav kfdkplyerl et // LOCUS NP_014412 384 aa linear PLN 30-JUN-2025 DEFINITION tRNA-dihydrouridine(20) synthase (NAD(+)) [Saccharomyces cerevisiae S288C]. ACCESSION NP_014412 VERSION NP_014412.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183192.1 REFERENCE 1 (residues 1 to 384) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 384) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 384) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 384) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10556. Method: conceptual translation. FEATURES Location/Qualifiers source 1..384 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..384 /product="tRNA-dihydrouridine(20) synthase (NAD(+))" /EC_number="1.3.1.91" /calculated_mol_wt="42685" Region 31..355 /region_name="Dus" /note="Dihydrouridine synthase (Dus); cl46871" /db_xref="CDD:481211" CDS 1..384 /gene="SMM1" /locus_tag="YNR015W" /gene_synonym="DUS2" /coded_by="NM_001183192.1:1..1155" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:12003496]" /experiment="EXISTENCE:direct assay:GO:0017150 tRNA dihydrouridine synthase activity [PMID:12003496]" /experiment="EXISTENCE:genetic interaction:GO:0008033 tRNA processing [PMID:12559567]" /experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:14970222]" /experiment="EXISTENCE:mutant phenotype:GO:0017150 tRNA dihydrouridine synthase activity [PMID:14970222]" /note="Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of the D loop of cytoplasmic pre-tRNAs" /db_xref="GeneID:855749" /db_xref="SGD:S000005298" ORIGIN 1 mvtyagklvl apmvragelp trlmalahga dlvwspeiid kkliqcvrke ntalqtvdyv 61 vpskvqtrpe tlvfrtypkl essklifqig saspalatqa alkvindvsg idinagcpkh 121 fsihsgmgsa llrtpdtlcl ilkelvknvg nphskpisvk irlldtkqdt lqlvkrlcat 181 gitnltvhcr ktemrnreqp itdyiaeiye icqannvsli vngairdrsh fhdlqanhwk 241 ntniggmiae caerdptvfd htskpsedgp swvvacrefi qwatkfdnhi gntkymlsri 301 vpgksvffqy farckspeev sfvlkqlndd gsaqtdpsey lencraqeka lknanaiakq 361 krkqtdhigs dtkkqkvvpl ptdi // LOCUS NP_014413 2233 aa linear PLN 30-JUN-2025 DEFINITION acetyl-CoA carboxylase ACC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014413 VERSION NP_014413.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183193.1 REFERENCE 1 (residues 1 to 2233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2233) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 2233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 2233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10557. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..2233 /product="acetyl-CoA carboxylase ACC1" /EC_number="6.3.4.14" /EC_number="6.4.1.2" /calculated_mol_wt="250223" Region 59..588 /region_name="PccA" /note="Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]; COG4770" /db_xref="CDD:443802" Region 701..767 /region_name="Biotin_lipoyl" /note="Biotin-requiring enzyme; pfam00364" /db_xref="CDD:395290" Site order(725,734..736,743) /site_type="active" /note="carboxyltransferase (CT) interaction site [active]" /db_xref="CDD:133459" Site 735 /site_type="other" /note="biotinylation site [posttranslational modification]" /db_xref="CDD:133459" Region 768..1479 /region_name="ACC_central" /note="Acetyl-CoA carboxylase, central region; pfam08326" /db_xref="CDD:462429" Region 1574..2118 /region_name="Carboxyl_trans" /note="Carboxyl transferase domain; pfam01039" /db_xref="CDD:426008" CDS 1..2233 /gene="ACC1" /locus_tag="YNR016C" /gene_synonym="ABP2; FAS3; MTR7" /coded_by="NM_001183193.1:1..6702" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9438137]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0003989 acetyl-CoA carboxylase activity [PMID:8098706]" /experiment="EXISTENCE:mutant phenotype:GO:0004075 biotin carboxylase activity [PMID:6108218]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:12730220]" /experiment="EXISTENCE:mutant phenotype:GO:0042759 long-chain fatty acid biosynthetic process [PMID:6103540]" /note="Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availability of acetyl-CoA; rate-limiting step for de novo biosynthesis of long-chain fatty acids; translational regulation in response to nutrients and cell cycle stage depends on its upstream ORF; ACC1 has a paralog, HFA1, that arose from the whole genome duplication" /db_xref="GeneID:855750" /db_xref="SGD:S000005299" ORIGIN 1 mseeslfess pqkmeyeitn yserhtelpg hfiglntvdk leesplrdfv kshgghtvis 61 kilianngia avkeirsvrk wayetfgddr tvqfvamatp edleanaeyi rmadqyievp 121 ggtnnnnyan vdlivdiaer advdavwagw ghasenpllp eklsqskrkv ifigppgnam 181 rslgdkisst ivaqsakvpc ipwsgtgvdt vhvdektglv svdddiyqkg cctspedglq 241 kakrigfpvm ikaseggggk girqvereed fialyhqaan eipgspifim klagrarhle 301 vqlladqygt nislfgrdcs vqrrhqkiie eapvtiakae tfhemekaav rlgklvgyvs 361 agtveylysh ddgkfyflel nprlqvehpt temvsgvnlp aaqlqiamgi pmhrisdirt 421 lygmnphsas eidfefktqd atkkqrrpip kghctacrit sedpndgfkp sggtlhelnf 481 rsssnvwgyf svgnngnihs fsdsqfghif afgenrqasr khmvvalkel sirgdfrttv 541 eylikllete dfedntittg wlddlithkm taekpdptla vicgaatkaf laseearhky 601 ieslqkgqvl skdllqtmfp vdfihegkry kftvaksgnd rytlfingsk cdiilrqlsd 661 gglliaiggk shtiywkeev aatrlsvdsm ttllevendp tqlrtpspgk lvkflvenge 721 hiikgqpyae ievmkmqmpl vsqengivql lkqpgstiva gdimaimtld dpskvkhalp 781 fegmlpdfgs pviegtkpay kfkslvstle nilkgydnqv imnaslqqli evlrnpklpy 841 sewklhisal hsrlpaklde qmeelvarsl rrgavfparq lsklidmavk npeynpdkll 901 gavvepladi ahkysnglea hehsifvhfl eeyyeveklf ngpnvreeni ilklrdenpk 961 dldkvaltvl shskvsaknn lilailkhyq plcklsskvs aifstplqhi veleskatak 1021 valqareili qgalpsvker teqiehilks svvkvaygss npkrsepdln ilkdlidsny 1081 vvfdvllqfl thqdpvvtaa aaqvyirray raytigdirv hegvtvpive wkfqlpsaaf 1141 stfptvkskm gmnravsvsd lsyvansqss plregilmav dhlddvdeil sqsleviprh 1201 qsssngpapd rsgssaslsn vanvcvaste gfeseeeilv rlreildlnk qelinasirr 1261 itfmfgfkdg sypkyytfng pnynenetir hiepalafql elgrlsnfni kpiftdnrni 1321 hvyeavskts pldkrfftrg iirtghirdd isiqeyltse anrlmsdild nlevtdtsns 1381 dlnhifinfi avfdispedv eaafggfler fgkrllrlrv ssaeiriiik dpqtgapvpl 1441 ralinnvsgy viktemytev knakgewvfk slgkpgsmhl rpiatpypvk ewlqpkryka 1501 hlmgttyvyd fpelfrqass sqwknfsadv kltddffisn eliedengel teverepgan 1561 aigmvafkit vktpeyprgr qfvvvandit fkigsfgpqe deffnkvtey arkrgipriy 1621 laansgarig maeeivplfq vawndaanpd kgfqylylts egmetlkkfd kensvltert 1681 vingeerfvi ktiigsedgl gveclrgsgl iagatsrayh diftitlvtc rsvgigaylv 1741 rlgqraiqve gqpiiltgap ainkmlgrev ytsnlqlggt qimynngvsh ltavddlagv 1801 ekivewmsyv pakrnmpvpi letkdtwdrp vdftptndet ydvrwmiegr etesgfeygl 1861 fdkgsffetl sgwakgvvvg rarlggiplg vigvetrtve nlipadpanp nsaetliqep 1921 gqvwhpnsaf ktaqaindfn ngeqlpmmil anwrgfsggq rdmfnevlky gsfivdalvd 1981 ykqpiiiyip ptgelrggsw vvvdptinad qmemyadvna ragvlepqgm vgikfrrekl 2041 ldtmnrlddk yrelrsqlsn kslapevhqq iskqladrer ellpiygqis lqfadlhdrs 2101 srmvakgvis kelewtearr fffwrlrrrl neeylikrls hqvgeasrle kiarirswyp 2161 asvdheddrq vatwieenyk tlddklkglk lesfaqdlak kirsdhdnai dglsevikml 2221 stddkekllk tlk // LOCUS NP_014414 222 aa linear PLN 30-JUN-2025 DEFINITION protein transporter TIM23 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014414 VERSION NP_014414.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183194.3 REFERENCE 1 (residues 1 to 222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 222) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10558. On Jul 30, 2012 this sequence version replaced NP_014414.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..222 /product="protein transporter TIM23" /calculated_mol_wt="23112" Region 61..212 /region_name="3a0801s02tim23" /note="mitochondrial import inner membrane translocase subunit tim23; TIGR00983" /db_xref="CDD:130056" CDS 1..222 /gene="TIM23" /locus_tag="YNR017W" /gene_synonym="MAS6; MIM23; MPI3" /coded_by="NM_001183194.3:1..669" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:11713477]" /experiment="EXISTENCE:direct assay:GO:0030943 mitochondrion targeting sequence binding [PMID:8858146]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:7600576|PMID:10830167]" /experiment="EXISTENCE:mutant phenotype:GO:0030943 mitochondrion targeting sequence binding [PMID:8858146]" /experiment="EXISTENCE:physical interaction:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:7600576]" /note="Essential core component of the TIM23 complex; subunit of the translocase of the inner mitochondrial membrane involved in protein import into the mitochondrial matrix and inner membrane; provides a structural role, contributing to the architecture of the import channel; functions as a voltage sensor and pre-sequence receptor" /db_xref="GeneID:855751" /db_xref="SGD:S000005300" ORIGIN 1 mswlfgdktp tddanaavgg qdttkpkels lkqslgfepn inniisgpgg mhvdtarlhp 61 lagldkgvey ldleeeqlss legsqglips rgwtddlcyg tgavyllglg iggfsgmmqg 121 lqnippnspg klqlntvlnh itkrgpflgn nagilalsyn iinstidalr gkhdtagsig 181 agaltgalfk sskglkpmgy ssamvaaaca vwcsvkkrll ek // LOCUS NP_014415 224 aa linear PLN 30-JUN-2025 DEFINITION Rcf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014415 VERSION NP_014415.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183195.1 REFERENCE 1 (residues 1 to 224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 224) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10559. Method: conceptual translation. FEATURES Location/Qualifiers source 1..224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..224 /product="Rcf2p" /calculated_mol_wt="25213" Region 115..165 /region_name="HIG_1_N" /note="Hypoxia induced protein conserved region; pfam04588" /db_xref="CDD:461361" CDS 1..224 /gene="RCF2" /locus_tag="YNR018W" /gene_synonym="AIM38" /coded_by="NM_001183195.1:1..675" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:22342701]" /experiment="EXISTENCE:direct assay:GO:0031334 positive regulation of protein-containing complex assembly [PMID:38508182]" /experiment="EXISTENCE:direct assay:GO:0098803 respiratory chain complex [PMID:22310663|PMID:22342701]" /experiment="EXISTENCE:genetic interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:22310663]" /note="Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; antagonistic with Min8p to control ETC assembly member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast" /db_xref="GeneID:855752" /db_xref="SGD:S000005301" ORIGIN 1 mkiltqdeie ahrshtlkgg iegalagfai saiifkvlpr rypkfkpstl twsiktalwi 61 tpptvltaic aeeasnnfda tmygsgssse daldehrrwk slstkdkfve glsnnkykii 121 tgawaaslyg swvivnkdpi mtkaqkivqa rmyaqfitvg lllasvglsm yenklhpnkq 181 kvnemrrwen alrvaeeeer lekegrrtgy vsneerinsk ifks // LOCUS NP_014416 642 aa linear PLN 30-JUN-2025 DEFINITION sterol acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014416 VERSION NP_014416.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183196.1 REFERENCE 1 (residues 1 to 642) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 642) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 642) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 642) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 642) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10560. Method: conceptual translation. FEATURES Location/Qualifiers source 1..642 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..642 /product="sterol acyltransferase" /calculated_mol_wt="73892" Region 106..642 /region_name="ARE1" /note="Acyl-CoA cholesterol acyltransferase [Lipid metabolism]; COG5056" /db_xref="CDD:227389" CDS 1..642 /gene="ARE2" /locus_tag="YNR019W" /gene_synonym="SAT1" /coded_by="NM_001183196.1:1..1929" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:10672016]" /experiment="EXISTENCE:genetic interaction:GO:0008204 ergosterol metabolic process [PMID:10672016]" /experiment="EXISTENCE:genetic interaction:GO:0034737 ergosterol O-acyltransferase activity [PMID:10672016]" /experiment="EXISTENCE:mutant phenotype:GO:0008204 ergosterol metabolic process [PMID:10672016]" /experiment="EXISTENCE:mutant phenotype:GO:0034737 ergosterol O-acyltransferase activity [PMID:10672016]" /note="Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication" /db_xref="GeneID:855753" /db_xref="SGD:S000005302" ORIGIN 1 mdkkkdllen eqflriqkln aadagkrqsi tvddegelyg ldtsgnspan ehtattitqn 61 hsvvasngdv afipgtateg nteivteevi etddnmfkth vktlsskeka ryrqgssnfi 121 syfddmsfeh rpsildgsvn epfktkfvgp tlekeirrre kelmamrknl hhrksspdav 181 dsvgkndgaa pttvptaats etvvtvetti issnfsglyv afwmaiafga vkalidyyyq 241 hngsfkdsei lkfmttnlft vasvdllmyl styfvvgiqy lckwgvlkwg ttgwiftsiy 301 eflfvifymy ltenilklhw lskiflflhs lvllmkmhsf afyngylwgi keelqfsksa 361 lakykdsind pkvigaleks cefcsfelss qslsdqtqkf pnnisaksff wftmfptliy 421 qieyprtkei rwsyvlekic aifgtiflmm idaqilmypv amralavrns ewtgildrll 481 kwvgllvdiv pgfivmyild fyliwdailn cvaeltrfgd ryfygdwwnc vswadfsriw 541 nipvhkfllr hvyhssmssf klnksqatlm tfflssvvhe lamyvifkkl rfylfffqml 601 qmplvaltnt kfmrnrtiig nvifwlgicm gpsvmctlyl tf // LOCUS NP_014417 270 aa linear PLN 30-JUN-2025 DEFINITION putative metalloprotease [Saccharomyces cerevisiae S288C]. ACCESSION NP_014417 VERSION NP_014417.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183197.3 REFERENCE 1 (residues 1 to 270) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 270) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 270) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 270) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 270) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10561. On Jul 30, 2012 this sequence version replaced NP_014417.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..270 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..270 /product="putative metalloprotease" /calculated_mol_wt="32096" Region 91..266 /region_name="Peptidase_M76" /note="Peptidase M76 family; pfam09768" /db_xref="CDD:430811" CDS 1..270 /gene="ATP23" /locus_tag="YNR020C" /coded_by="NM_001183197.3:1..813" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:17135288]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:17135288]" /experiment="EXISTENCE:mutant phenotype:GO:0034982 mitochondrial protein processing [PMID:17135290|PMID:17135288]" /note="Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p" /db_xref="GeneID:855754" /db_xref="SGD:S000005303" ORIGIN 1 mtmrtnkknk ssnikmirrv rhnlynqnqg klivpnffff whdmnssgdn agfewwrrtm 61 qyktgigltp eektryedds karelkkecl kcyeyrdwml kysptvrfmv qaitklnkgs 121 dskfddskii cdycpdwkgg gfhpelgill cqnrlrdkwh ledtlsheli hyfddlkwqi 181 dwlnlkhhac seirasslsg ecrfweefkr rgfrtgfhva rghqdcvrrr aiisvsgnpn 241 cqskehaaki vdevwdscfa dtrpfdeiyr // LOCUS NP_014418 404 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNR021W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014418 VERSION NP_014418.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183198.3 REFERENCE 1 (residues 1 to 404) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 404) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 404) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 404) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10562. On Jul 30, 2012 this sequence version replaced NP_014418.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..404 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..404 /product="uncharacterized protein" /calculated_mol_wt="46962" Region 44..394 /region_name="CCDC47" /note="PAT complex subunit CCDC47; pfam07946" /db_xref="CDD:462322" CDS 1..404 /locus_tag="YNR021W" /coded_by="NM_001183198.3:1..1215" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene" /db_xref="GeneID:855755" /db_xref="SGD:S000005304" ORIGIN 1 msssifgplt gflervnsln apyqalsyde qkamtiwqrv kfynwtfelc algvlflvya 61 fykfgnsvnl krgnqifqsl hsflandlkf srvgfninds kiftvehqnt wfssfatgrs 121 aiksinlnlh lvarsnpfsm cleyllgfff aslkskqlee fmeivirpng ilvtsesahp 181 nknaheiltk frfvtsivnk efmnqarten yflsiahtse ndklpnnfvy msdvnqlsgf 241 mfhyskpyev lsqagnllky isftdlpvnp prddkewess iepkaiirca vpqnenelkl 301 lnqiislvve iydgftqdlv qqspnlfitn dilkrttnlr qqelnkikkf mketelelak 361 ekklelekak rrqlkasgqq ekvdqkmkek rerrlknkqr trfq // LOCUS NP_014419 139 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL9m MRPL50 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014419 VERSION NP_014419.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183199.1 REFERENCE 1 (residues 1 to 139) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 139) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 139) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 139) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10563. Method: conceptual translation. FEATURES Location/Qualifiers source 1..139 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..139 /product="mitochondrial 54S ribosomal protein bL9m MRPL50" /calculated_mol_wt="16152" Region 19..>49 /region_name="Ribosomal_L9_N" /note="Ribosomal protein L9, N-terminal domain; pfam01281" /db_xref="CDD:460146" CDS 1..139 /gene="MRPL50" /locus_tag="YNR022C" /gene_synonym="bL9m" /coded_by="NM_001183199.1:1..420" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit; not essential for mitochondrial translation" /db_xref="GeneID:855756" /db_xref="SGD:S000005305" ORIGIN 1 mlhctqvcls altkrthrvk vqvlkdfprf qlykgqvanv kpslmrnylh nfngakyils 61 eehdintell kqyqtleakl eedhqqlskr hetevqknme lrkesvfghk keekpkeekk 121 glldsgitie evkipgldi // LOCUS NP_014420 566 aa linear PLN 30-JUN-2025 DEFINITION Snf12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014420 VERSION NP_014420.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183200.1 REFERENCE 1 (residues 1 to 566) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 566) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 566) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 566) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10564. Method: conceptual translation. FEATURES Location/Qualifiers source 1..566 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..566 /product="Snf12p" /calculated_mol_wt="63740" Region 310..415 /region_name="SWIB_like" /note="SWIB domain found in the 60 kda subunit of the ATP-dependent SWI/SNF chromatin-remodeling complexes and similar proteins; cd10568" /db_xref="CDD:349490" Site order(326,329..330,332..333,336..337,342,347,377,379,403, 406..407) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:349490" CDS 1..566 /gene="SNF12" /locus_tag="YNR023W" /gene_synonym="SWP73" /coded_by="NM_001183200.1:1..1701" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:8127913|PMID:18644858]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8804308]" /experiment="EXISTENCE:mutant phenotype:GO:0000785 chromatin [PMID:28249159]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:28249159]" /experiment="EXISTENCE:mutant phenotype:GO:0030527 structural constituent of chromatin [PMID:28249159]" /experiment="EXISTENCE:mutant phenotype:GO:0034198 cellular response to amino acid starvation [PMID:10549298]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10549298|PMID:8816487]" /note="73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication" /db_xref="GeneID:855757" /db_xref="SGD:S000005306" ORIGIN 1 mskvmkpsng kgsrksskaa tpdtknffha kkkdpvnqdk annasqitpt vphshpsdmv 61 ipdhlaelip elysfqqlvd sekrldhfih lrnlhmkrmv aqwersklsq eflyphlnfp 121 nvkflrifis nvsenqpwqm dtnneadlma lenatwtmri egrlldnvqa ndparekfss 181 fiesivvdfk nkendnvpst kfnaapeena tegpsdkkln lnlplqfslp ngdnstttnt 241 dqnnatmgee takkdmsstt pklesvkwqy dpnnpvdfdg ldikrvgsen vectisilrk 301 sspeepfmsy spqltaiigl ksgtshdaif siykyihlne lltndesafe nlmgnrnnhn 361 sntstskmld aassqvsivk ldtqlitllp sslkesspdt mkltdllsli nsthllplqp 421 ieidytvrvd kastygelvl dievpdvnal kfnntqresq igaaelnena releqikpki 481 alqdkeitsv lsnlhesnkr yrffkkised pvkalnecia stsnalkvls gdegynedmv 541 rranfykene amlrenievi lsngrm // LOCUS NP_014421 186 aa linear PLN 30-JUN-2025 DEFINITION Mpp6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014421 VERSION NP_014421.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183201.3 REFERENCE 1 (residues 1 to 186) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 186) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 186) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 186) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10565. On Jul 30, 2012 this sequence version replaced NP_014421.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..186 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..186 /product="Mpp6p" /calculated_mol_wt="21011" Region 10..182 /region_name="MPP6" /note="M-phase phosphoprotein 6; pfam10175" /db_xref="CDD:462978" CDS 1..186 /gene="MPP6" /locus_tag="YNR024W" /coded_by="NM_001183201.3:1..561" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095|PMID:18591258]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0008266 poly(U) RNA binding [PMID:18591258]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:18591258|PMID:19046973]" /experiment="EXISTENCE:genetic interaction:GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing [PMID:18591258]" /experiment="EXISTENCE:genetic interaction:GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing [PMID:18591258]" /experiment="EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:18591258]" /experiment="EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:18591258]" /experiment="EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18591258]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27076633]" /note="Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:855758" /db_xref="SGD:S000005307" ORIGIN 1 msanngvtgk lssrvmnmkf mkfgktddee ssnsntpsni nsdvepieqk gklfglddsa 61 wdlnsykddl kkisgkekkk vkrvvykkrp nliisnvgys elrkpegvis grktfgdnsd 121 dsgsrkrkfd egeqnedekr dakdkeftgs qddgedeydl dklfkdsikk kktnhngknk 181 nrnskk // LOCUS NP_014423 471 aa linear PLN 30-JUN-2025 DEFINITION Sar family guanine nucleotide exchange factor SEC12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014423 VERSION NP_014423.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183203.1 REFERENCE 1 (residues 1 to 471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 471) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10566. Method: conceptual translation. FEATURES Location/Qualifiers source 1..471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..471 /product="Sar family guanine nucleotide exchange factor SEC12" /calculated_mol_wt="51477" Region <138..335 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 177..212 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 219..258 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 270..305 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 312..360 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 368..431 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..471 /gene="SEC12" /locus_tag="YNR026C" /gene_synonym="SED2" /coded_by="NM_001183203.1:1..1416" /experiment="EXISTENCE:direct assay:GO:0003400 regulation of COPII vesicle coating [PMID:8377826]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8583945|PMID:8377826]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8707815|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:3047151]" /experiment="EXISTENCE:mutant phenotype:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:8377826]" /note="Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication" /db_xref="GeneID:855760" /db_xref="SGD:S000005309" ORIGIN 1 mkfvtasynv gypaygakfl nndtllvagg ggegnngipn kltvlrvdpt kdtekeqfhi 61 lsefalednd dsptaidask giilvgcnen stkitqgkgn khlrkfkydk vndqleflts 121 vdfdastnad dytklvyisr egtvaaiass kvpaimriid psdltekfei etrgevkdlh 181 fstdgkvvay itgsslevis tvtgsciark tdfdknwsls kinfiaddtv liaaslkkgk 241 givltkisik sgntsvlrsk qvtnrfkgit smdvdmkgel avlasndnsi alvklkdlsm 301 skifkqahsf aitevtispd styvasvsaa ntihiiklpl nyanytsmkq kiskfftnfi 361 livllsyilq fsykhnlhsm lfnyakdnfl tkrdtisspy vvdedlhqtt lfgnhgtkts 421 vpsvdsikvh gvhetssvng tevlctesni intggaefei tnatfreidd a // LOCUS NP_014424 317 aa linear PLN 30-JUN-2025 DEFINITION putative pyridoxal kinase BUD17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014424 VERSION NP_014424.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183204.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10567. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..317 /product="putative pyridoxal kinase BUD17" /EC_number="2.7.1.35" /calculated_mol_wt="35236" Region 10..274 /region_name="pyridoxal_pyridoxamine_kinase" /note="Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; cd01173" /db_xref="CDD:238578" Site order(10,17,19..20,22,26,30,33,38..43,46,49,58..59,61, 68..69,76) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238578" Site order(16,23..24,47,50..51,56,89,91,229..230,233) /site_type="other" /note="pyridoxal binding site [chemical binding]" /db_xref="CDD:238578" Site order(118,123,150,152,155,190..191,202,221,223..224,228, 231..233,235,265,269) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238578" CDS 1..317 /gene="BUD17" /locus_tag="YNR027W" /coded_by="NM_001183204.1:1..954" /experiment="EXISTENCE:curator inference:GO:0042823 pyridoxal phosphate biosynthetic process [PMID:9099727]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative pyridoxal kinase; a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)" /db_xref="GeneID:855761" /db_xref="SGD:S000005310" ORIGIN 1 mtstlhttkk vlsiqshvih gyvgnkaatf plqyrgwdvd vlntvqfsnh sgyahftgfk 61 csteelvdiv ekgligslri kydavlsgyl pnvqalqkva givgqlcegs envkwildpv 121 lgdngrlyvd recvavyqdi lqnfkiflat pnqfemellv gmsirtldda kqafklfhkk 181 yprvsrivvt slelseflsn dtyvvagfdc saseeiffye ipkinakfsg sgdlisamlt 241 dsllgdrrct qlslsaslgq vlwlvtsilq ktydlniaer gpqdstidik dlkliqcrdi 301 lkqdlipsig kpktiki // LOCUS NP_014425 308 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase family protein CPR8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014425 VERSION NP_014425.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183205.3 REFERENCE 1 (residues 1 to 308) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 308) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 308) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 308) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10568. On Jul 30, 2012 this sequence version replaced NP_014425.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..308 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..308 /product="peptidylprolyl isomerase family protein CPR8" /EC_number="5.2.1.8" /calculated_mol_wt="34815" Region 65..210 /region_name="Pro_isomerase" /note="Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD; pfam00160" /db_xref="CDD:459694" CDS 1..308 /gene="CPR8" /locus_tag="YNR028W" /coded_by="NM_001183205.3:1..927" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /note="Peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; potential role in the secretory pathway; CPR8 has a paralog, CPR4, that arose from the whole genome duplication" /db_xref="GeneID:855762" /db_xref="SGD:S000005311" ORIGIN 1 mksfflylyv afmfscital plpvdnkras sdsldlkkky apdppithnv nigivftdpe 61 sseeagrlit idlygtmvpk tvmtfcqyvd svkdrlasrh sysperdfdk ilpngaiegs 121 svssssieet emlapklpee nhslihdrpg rvsmikddkg lkfiietset plegesvvfg 181 qvtaglkdlm dklanvktde ngkpeqpiti gyissqehri qhakeaheky lqrlqdyqng 241 dlekgitlkn ylyqgsqrkl edakynqlhh plpkimlgis vlllfyvlak yrkrifnrss 301 kivsired // LOCUS NP_014426 429 aa linear PLN 30-JUN-2025 DEFINITION GTP-dependent zinc transferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014426 VERSION NP_014426.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183206.3 REFERENCE 1 (residues 1 to 429) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 429) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 429) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 429) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10569. On Jul 30, 2012 this sequence version replaced NP_014426.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..429 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..429 /product="GTP-dependent zinc transferase" /calculated_mol_wt="47991" Region 72..289 /region_name="CobW-like" /note="cobalamin synthesis protein CobW; cd03112" /db_xref="CDD:349766" Site order(81..86,166,244..245) /site_type="active" /note="putative active site [active]" /db_xref="CDD:349766" Site order(104,109,138) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:349766" Region <366..428 /region_name="CobW_C" /note="Cobalamin synthesis protein cobW C-terminal domain; pfam07683" /db_xref="CDD:462228" CDS 1..429 /gene="ZNG1" /locus_tag="YNR029C" /coded_by="NM_001183206.3:1..1290" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:35584675]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:35584675]" /experiment="EXISTENCE:direct assay:GO:0140827 zinc chaperone activity [PMID:35584675]" /experiment="EXISTENCE:genetic interaction:GO:0034224 cellular response to zinc ion starvation [PMID:35584675]" /experiment="EXISTENCE:genetic interaction:GO:0051604 protein maturation [PMID:35584675]" /experiment="EXISTENCE:mutant phenotype:GO:0034224 cellular response to zinc ion starvation [PMID:35584675]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:35584675]" /note="GTP-dependent zinc transferase; couples GTP hydrolysis to the activation of methionine aminopeptidase Map1p, especially during zinc starvation; deletion confers reduced fitness in saline; contains GTPase sequence motifs and a CxCC metal-binding motif" /db_xref="GeneID:855763" /db_xref="SGD:S000005312" ORIGIN 1 msalrnikfn eeedgelpcl vtgeennlqe ilenvsydgg nivsdakver vnkqventsa 61 gatdvhekkr ipvsiitgyl gsgkstllek ialkgadkki avilnefgds seiekamtik 121 ngsnsyqewl dlgngclccs lknigvkaie dmverspgki dyilletsgi adpapiakmf 181 wqdeglnssv yidgiitvld cehilkcldd isidahwhgd kvglegnlti ahfqlamadr 241 iimnkydtie hspemvkqlk ervreinsia pmfftkysdt piqnlldiha ydsvrisdil 301 dsgsgngtih ddrmgtimlt frplkneeey nnkfikqflq pllwknfgam tvlggrrrdd 361 grdwevqrtk gliliegenp iarviqgvrd tydvfpgkyd gsnkeckivl igkylekesi 421 eellrktle // LOCUS NP_014427 551 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014427 VERSION NP_014427.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183207.1 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10570. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..551 /product="dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase" /EC_number="2.4.1.260" /calculated_mol_wt="62542" Region 8..380 /region_name="PMT_2" /note="Dolichyl-phosphate-mannose-protein mannosyltransferase; cl21590" /db_xref="CDD:473917" CDS 1..551 /gene="ALG12" /locus_tag="YNR030W" /gene_synonym="ECM39" /coded_by="NM_001183207.1:1..1656" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:10336995]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:12460938|PMID:10336995]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:10336995]" /note="Alpha-1,6-mannosyltransferase localized to the ER; responsible for addition of alpha-1,6 mannose to dolichol-linked Man7GlcNAc2; acts in the dolichol pathway for N-glycosylation; human homolog ALG12 complements yeast null mutant" /db_xref="GeneID:855764" /db_xref="SGD:S000005313" ORIGIN 1 mrwsvldtvl ltvisfhliq apftkveesf niqaihdilt ysvfdisqyd hlkfpgvvpr 61 tfvgaviiam lsrpylylss liqtsrptsi dvqlvvrgiv gltnglsfiy lknclqdmfd 121 eitekkkeen edkdiyiyds agtwfllfli gsfhlmfyst rtlpnfvmtl pltnvalgwv 181 llgrynaaif lsalvaivfr levsalsagi alfsvifkki slfdaikfgi fglglgsais 241 itvdsyfwqe wclpevdgfl fnvvagyask wgvepvtayf thylrmmfmp ptvlllnyfg 301 yklapaklki vslaslfhii vlsfqphkew rfiiyavpsi mllgatgaah lwenmkvkki 361 tnvlclailp lsimtsffis maflyisrmn ypggealtsf ndmiveknit natvhisipp 421 cmtgvtlfge lnygvyginy dktenttllq emwpsfdfli theptasqlp fenkttnhwe 481 lvnttkmftg fdptyiknfv fqervnvlsl lkqiifdktp tvflkeltan sivksdvfft 541 ykrikqdekt d // LOCUS NP_014428 1579 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase kinase kinase SSK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014428 VERSION NP_014428.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183208.1 REFERENCE 1 (residues 1 to 1579) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1579) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1579) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1579) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10571. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1579 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1579 /product="mitogen-activated protein kinase kinase kinase SSK2" /EC_number="2.7.11.25" /calculated_mol_wt="180397" Region 1265..1558 /region_name="STKc_MEKK4" /note="Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4; cd06626" /db_xref="CDD:270796" Site order(1272..1276,1280,1293,1295,1328,1344..1347,1350..1351, 1354,1390,1392..1395,1397,1407..1408,1411,1457..1460,1462, 1492,1501) /site_type="active" /db_xref="CDD:270796" Site order(1272..1276,1280,1293,1295,1328,1344..1347,1349..1351, 1354,1394..1395,1397,1407..1409) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270796" Site order(1275..1276,1390,1392..1394,1411,1457..1460,1462,1492, 1501) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270796" Site order(1407..1416,1456..1462) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270796" CDS 1..1579 /gene="SSK2" /locus_tag="YNR031C" /coded_by="NM_001183208.1:1..4740" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12857882]" /experiment="EXISTENCE:direct assay:GO:0003779 actin binding [PMID:12181352]" /experiment="EXISTENCE:direct assay:GO:0004709 MAP kinase kinase kinase activity [PMID:9482735]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12181352]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12857882]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12857882|PMID:12181352]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:12181352|PMID:12857882]" /experiment="EXISTENCE:direct assay:GO:0071474 cellular hyperosmotic response [PMID:12181352|PMID:9482735]" /experiment="EXISTENCE:genetic interaction:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:9482735]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:12857882]" /experiment="EXISTENCE:genetic interaction:GO:0038066 p38MAPK cascade [PMID:7624781|PMID:9742096]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:12857882]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:12857882|PMID:12181352]" /experiment="EXISTENCE:mutant phenotype:GO:0038066 p38MAPK cascade [PMID:7624781]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:12857882|PMID:12181352]" /experiment="EXISTENCE:physical interaction:GO:0007234 osmosensory signaling via phosphorelay pathway [PMID:9482735]" /note="MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress; a HOG-independent function of Ssk2p mediates the calcium-sensitive phenotype of the ptp2 msg5 double disruptant; SSK2 has a paralog, SSK22, that arose from the whole genome duplication" /db_xref="GeneID:855765" /db_xref="SGD:S000005314" ORIGIN 1 mshsdyfnyk pygdstekps sskmrqssss sssrlrsesl grnsnttqar vasspispgl 61 hstqyfrspn avyspgespl ntvqlfnrlp gipqgqffhq naisgsssss arssrrpsni 121 glplpknpqq slpklstqpv pvhkkveask teseiikkpa pvnsnqdpll ttptlvispe 181 laslnttnts imstpqnitn qtsnkhiptr sqpngstsss tlqdivttns sqrsvghhgg 241 sttslrtykk qyvlneqlyl rkmrnrandd yytrgivass nfeddeenfs nkgeddlele 301 mddllkvege dkdndfnfgy nfitsstknn envvsmslny lkgkldwlrd vnndqpceie 361 deewhsilgs edllskllqn pmvnnrfewq tmlskvlkgd ivrnektkia nqgkgpgfnt 421 qfsddiwiel kawmngrtve dqnkslrifr dstdsvfqei mafklednms adeaaetiks 481 lvdkyyrvln lwpnikrmha ekpitkteaf rnridtlnsw lnfkfnfdtn iaylkkwivg 541 nkelesttev dnttvnlddp avfatnckrf aeqimkekdi elifqkkiff plapwilkak 601 ffflkyqktw nelnlsyldq dlefllmfpm rlvkdiilir lsyakkiqnp tlmmidqmmd 661 dfstyiklav qmkftvasyc ndwffkvkid pefdhtvveg leyffsilel rilysgknsf 721 ktskepdlll kywemfrnvg yyiddageli aaeftkltlr lvhrlhayll rqqntppkle 781 neaaaekwlv qifeilgsmk rklnrftnil tkafqnfvry kiedhnyllk qlketghfli 841 ytggyleqng tyligspell gckdddilri iknsdigcdl vpkleinnsl tiynalddnw 901 nsnsslgsdi sndgtpfyyi kndlttqprs yngnrvnrep dfensrstee efyeletrln 961 slgyvlvltp qepllwegem ynlsdnktik peglnlkvip nsidlmcqgs syaleyqcdr 1021 fqqisgssvs flekkssset vknnlqrink ayfrctysvl knytkivttf kkvspvndll 1081 nniflfgrdf glnflrinva nnekrsiiil lmmrlsigwl kflaedcdpt dqrvfrwcvt 1141 smefamhmvs gwnilaldec qfsslkqkis ecmsllishf diigarsiev ekinqqarsn 1201 ldledvfddd mmlqvnsefr vqsimeleer ikrnphqtgk viddsdkgnk ylvslassis 1261 nvsmrwqkrn figggtfgrv ysavdldnge ilavkeiniq dsksmqkifp likeemsvle 1321 ilnhpnivsy ygvevhrdkv nifmeycegg slaallehgr iedemvtqvy tlqlleglay 1381 lhesgivhrd vkpenilldf ngvikyvdfg aakkianngt rlasmnkien adgehedvth 1441 vsdskavknn enalldmmgt pmymapesit gsttkgklga ddvwslgcvv lemitgrrpw 1501 anldnewaim yhvaaghtpq fptkdevssa gmkflercli qnpskrasav ellmdpwivq 1561 ireiafgdds sstdteere // LOCUS NP_014429 368 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine-protein kinase PPG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014429 VERSION NP_014429.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183209.3 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10572. On Jul 30, 2012 this sequence version replaced NP_014429.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..368 /product="putative serine/threonine-protein kinase PPG1" /EC_number="3.1.3.16" /calculated_mol_wt="42302" Region 2..299 /region_name="MPP_PP2A_PP4_PP6" /note="PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain; cd07415" /db_xref="CDD:277360" Site order(44,60,63..64,66..67,69,71..72,84,99..103,114..115, 118..119,123..124,127..128,137,274,283,293,299) /site_type="other" /note="heterotrimer interface [polypeptide binding]" /db_xref="CDD:277360" Site order(50,52,78,82,110..111,115..116,120,161,183..185,194, 219..221,247,249,273..275) /site_type="active" /db_xref="CDD:277360" Site order(50,52,78,110,161,247) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277360" CDS 1..368 /gene="PPG1" /locus_tag="YNR032W" /coded_by="NM_001183209.3:1..1107" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:33317697]" /experiment="EXISTENCE:mutant phenotype:GO:0004722 protein serine/threonine phosphatase activity [PMID:33317697]" /experiment="EXISTENCE:mutant phenotype:GO:0005977 glycogen metabolic process [PMID:7678255]" /experiment="EXISTENCE:mutant phenotype:GO:1901525 negative regulation of mitophagy [PMID:33317697]" /note="Serine protein phosphatase involved in formation of FAR complex; inhibits mitophagy by dephosphorylating Atg32p; required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases" /db_xref="GeneID:855766" /db_xref="SGD:S000005315" ORIGIN 1 meldeclerl ykaqllpevt vralcfklke mlvkesnvih iqtpvtvvgd mhgqfhdmle 61 ifqiggpvpd tnylflgdyv drglysveti mllivlklry psrihllrgn hesrqitqsy 121 gfyteclnky ggnsrvwqyl tdifdylvlc ciiddeifcv hgglspnvqt idqikiidrf 181 reiphdgama dlvwsdpeen nnptldhpdn sgqhfqvspr gagytfgrsv vekflrmndm 241 nriyrahqlc negyqiyfdg lvttvwsapn ycyrcgnkas ilelyskdqf yfnvfeeape 301 nkllkensmn dnaledsisn pvanrkliad yfeddsasad gstdpemyif sdvyqarsas 361 nrhvdyfl // LOCUS NP_014430 73 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-like protein HUB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014430 VERSION NP_014430.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184344.1 REFERENCE 1 (residues 1 to 73) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 73) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 73) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 73) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 73) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10573. Method: conceptual translation. FEATURES Location/Qualifiers source 1..73 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..73 /product="ubiquitin-like protein HUB1" /calculated_mol_wt="8140" Region 1..71 /region_name="Ubl_UBL5" /note="ubiquitin-like (Ubl) domain found in ubiquitin-like protein 5 (UBL5) and similar proteins; cd01791" /db_xref="CDD:340489" Site order(1,15,17..19,22,26,29..30,33..34) /site_type="other" /note="HIND interaction site [polypeptide binding]" /db_xref="CDD:340489" CDS 1..73 /gene="HUB1" /locus_tag="YNR032C-A" /coded_by="NM_001184344.1:1..222" /experiment="EXISTENCE:direct assay:GO:0031386 protein tag activity [PMID:11923536]" /experiment="EXISTENCE:direct assay:GO:0043687 post-translational protein modification [PMID:11923536]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:11923536]" /experiment="EXISTENCE:mutant phenotype:GO:0033120 positive regulation of RNA splicing [PMID:31666190]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:15620657]" /note="Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear" /db_xref="GeneID:855767" /db_xref="SGD:S000007251" ORIGIN 1 mievvvndrl gkkvrvkcla edsvgdfkkv lslqigtqpn kivlqkggsv lkdhisledy 61 evhdqtnlel yyl // LOCUS NP_014431 787 aa linear PLN 30-JUN-2025 DEFINITION 4-amino-4-deoxychorismate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014431 VERSION NP_014431.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183210.1 REFERENCE 1 (residues 1 to 787) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 787) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 787) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 787) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 787) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10574. Method: conceptual translation. FEATURES Location/Qualifiers source 1..787 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..787 /product="4-amino-4-deoxychorismate synthase" /EC_number="2.6.1.85" /calculated_mol_wt="88413" Region 10..787 /region_name="PabB-fungal" /note="aminodeoxychorismate synthase, fungal clade; TIGR01823" /db_xref="CDD:273821" CDS 1..787 /gene="ABZ1" /locus_tag="YNR033W" /coded_by="NM_001183210.1:1..2364" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008153 4-aminobenzoate biosynthetic process [PMID:8346682]" /experiment="EXISTENCE:mutant phenotype:GO:0046820 4-amino-4-deoxychorismate synthase activity [PMID:8346682]" /note="Para-aminobenzoate (PABA) synthase; has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855768" /db_xref="SGD:S000005316" ORIGIN 1 mlsdtidtkq qqqqlhvlfi dsydsftynv vrlieqqtdi spgvnavhvt tvhsdtfqsm 61 dqllpllplf daivvgpgpg npnngaqdmg iiselfenan gkldevpilg iclgfqamcl 121 aqgadvseln tikhgqvyem hlndaaracg lfsgypdtfk stryhslhvn aegidtllpl 181 cttedengil lmsaqtknkp wfgvqyhpes ccselggllv snflklsfin nvktgrwekk 241 klngefsdil srldrtidrd piykvkekyp kgedttyvkq fevsedpklt feicniiree 301 kfvmsssvis entgewsiia lpnsasqvft hygamkkttv hywqdseisy tllkkcldgq 361 dsdlpgslev ihedksqfwi tlgkfmenki idnhreipfi gglvgilgye igqyiacgrc 421 nddenslvpd aklvfinnsi vinhkqgkly cisldntfpv aleqslrdsf vrkknikqsl 481 swpkylpeei dfiitmpdkl dyakafkkcq dymhkgdsye mclttqtkvv psaviepwri 541 fqtlvqrnpa pfssffefkd iiprqdetpp vlcflstspe rflkwdadtc elrpikgtvk 601 kgpqmnlaka trilktpkef genlmildli rndlyelvpd vrveefmsvq eyatvyqlvs 661 vvkahgltsa skktrysgid vlkhslppgs mtgapkkitv qllqdkiesk lnkhvnggar 721 gvysgvtgyw svnsngdwsv nircmysyng gtswqlgagg aitvlstldg eleemynkle 781 snlqifm // LOCUS NP_014432 321 aa linear PLN 30-JUN-2025 DEFINITION Sol1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014432 VERSION NP_014432.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183211.3 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10575. On Jul 30, 2012 this sequence version replaced NP_014432.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..321 /product="Sol1p" /calculated_mol_wt="35521" Region 92..296 /region_name="6PGL" /note="6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the...; cd01400" /db_xref="CDD:238694" Site order(100..101,128,209,241,264) /site_type="active" /note="putative active site [active]" /db_xref="CDD:238694" CDS 1..321 /gene="SOL1" /locus_tag="YNR034W" /coded_by="NM_001183211.3:1..966" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15454531|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:15454531]" /note="Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855769" /db_xref="SGD:S000005317" ORIGIN 1 mtttvpkvfa fhefagvaea vadhvihaqn salkkgkvsr stqmsgtsln gngntesktm 61 ervnsvrsna ssrggsedga tkklkkeker rfkialsggs liqvlhegll krddvqwgkw 121 diyfaderlv pfsssesnyg lakrkifdli dtekygtpki yhideslind pqecadnyek 181 ilikgfagrd svklpmfdlf llgcapdghi aslfpnfqen lrenlawvip venapsgpsn 241 risltipvic hshrvtfvve gatkapvikt imerpekglp ssivnegaag rvswfvddda 301 lkdvfvikkk ykfyddenlt e // LOCUS NP_061494 98 aa linear PLN 30-JUN-2025 DEFINITION Ego4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_061494 VERSION NP_061494.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184446.3 REFERENCE 1 (residues 1 to 98) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 98) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 98) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 98) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 98) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10576. On Jul 30, 2012 this sequence version replaced NP_061494.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..98 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..98 /product="Ego4p" /calculated_mol_wt="10650" Region 7..82 /region_name="DUF3215" /note="Protein of unknown function (DUF3215); pfam11503" /db_xref="CDD:371567" CDS 1..98 /gene="EGO4" /locus_tag="YNR034W-A" /coded_by="NM_001184446.3:1..297" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26206314]" /note="hypothetical protein; expressed during diauxic shift and stationary phase, and negatively regulated by glucose; expression is regulated by Msn2p/Msn4p; overexpression slows down progression through meiosis and improves fermentative efficiency; YNR034W-A has a paralog, YCR075W-A, that arose from the whole genome duplication" /db_xref="GeneID:855770" /db_xref="SGD:S000007525" ORIGIN 1 mkssipitev lpravgsltf denynlldts gvakvieksp iaeiirksna elgrlgysvy 61 edaqyighaf kkaghfivyf tpknknregv vppvgitn // LOCUS NP_014433 342 aa linear PLN 30-JUN-2025 DEFINITION Arc35p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014433 VERSION NP_014433.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183212.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10577. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..342 /product="Arc35p" /calculated_mol_wt="39435" Region 56..316 /region_name="P34-Arc" /note="Arp2/3 complex, 34 kD subunit p34-Arc; pfam04045" /db_xref="CDD:461144" CDS 1..342 /gene="ARC35" /locus_tag="YNR035C" /gene_synonym="END9" /coded_by="NM_001183212.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:14554195]" /experiment="EXISTENCE:direct assay:GO:0005885 Arp2/3 protein complex [PMID:10377407|PMID:9210376]" /experiment="EXISTENCE:mutant phenotype:GO:0000226 microtubule cytoskeleton organization [PMID:14554195]" /experiment="EXISTENCE:mutant phenotype:GO:0006898 receptor-mediated endocytosis [PMID:7929582]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:14554195]" /experiment="EXISTENCE:mutant phenotype:GO:0044396 actin cortical patch organization [PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:10377407]" /experiment="EXISTENCE:mutant phenotype:GO:0072697 protein localization to cell cortex [PMID:10749918]" /experiment="EXISTENCE:physical interaction:GO:0005516 calmodulin binding [PMID:10749918]" /note="Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin" /db_xref="GeneID:855771" /db_xref="SGD:S000005318" ORIGIN 1 mlhlqpqnll iqktlneaie alrkgspltm drivsdfdyt tyhisntaed ksilllsvkt 61 kawvsvsecq ldgsltllkf ladhysslgg vtipsevepg ydytlqitla elvqesilql 121 svlktiilsf pfelaiskfi elsqqqpapv eaeitggeva angdntlfti kyrdeenifi 181 kpsndrvtii fetifqdetd kifgkvflqe fvdarkrnrq iqsapqvlys hepplelkrl 241 yqppkvaeqs rrfitfvlfp rhfqtkelqf hsicqltlfr nyfhyhikcs kaymhsrmrf 301 rvdsfikvln rakvdedden delsaegrqq arrtftgrki vy // LOCUS NP_014434 153 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS12m MRPS12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014434 VERSION NP_014434.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183213.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10578. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..153 /product="mitochondrial 37S ribosomal protein uS12m MRPS12" /calculated_mol_wt="16786" Region 28..152 /region_name="rpsL_bact" /note="ribosomal protein S12, bacterial/organelle; TIGR00981" /db_xref="CDD:130054" Site order(31..32,34..35,39..40) /site_type="other" /note="S17 interaction site [polypeptide binding]" /db_xref="CDD:239466" Site 31 /site_type="active" /note="S8 interaction site [active]" /db_xref="CDD:239466" Site order(40..42,54,56..57,59,74..75,77..79,86,94,97..98, 111..112,116..117,138) /site_type="other" /note="16S rRNA interaction site [nucleotide binding]" /db_xref="CDD:239466" Site order(71..72,116) /site_type="other" /note="streptomycin interaction site [chemical binding]" /db_xref="CDD:239466" Site 72..73 /site_type="other" /note="23S rRNA interaction site [nucleotide binding]" /db_xref="CDD:239466" Site order(73..78,98..106) /site_type="other" /note="aminoacyl-tRNA interaction site (A-site) [nucleotide binding]" /db_xref="CDD:239466" CDS 1..153 /gene="MRPS12" /locus_tag="YNR036C" /gene_synonym="uS12m" /coded_by="NM_001183213.1:1..462" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:30520011]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:28154081]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:28154081]" /note="Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins" /db_xref="GeneID:855772" /db_xref="SGD:S000005319" ORIGIN 1 mlsrfmsntw ctplrqaqrl fsstttmqat lnqikrgsgp prrkkistap qldqcpqrkg 61 vvlrvmvlkp kkpnsaqrka crvrltngnv vsayipgegh daqehsivyv rggrcqdlpg 121 vkyhvirgag dlsgvvnris srskygakkp sks // LOCUS NP_014435 91 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS19m RSM19 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014435 VERSION NP_014435.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183214.3 REFERENCE 1 (residues 1 to 91) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 91) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 91) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 91) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 91) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 91) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 91) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 91) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10579. On Jul 30, 2012 this sequence version replaced NP_014435.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..91 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..91 /product="mitochondrial 37S ribosomal protein uS19m RSM19" /calculated_mol_wt="10144" Region 11..85 /region_name="Ribosomal_S19" /note="Ribosomal protein S19; pfam00203" /db_xref="CDD:459710" CDS 1..91 /gene="RSM19" /locus_tag="YNR037C" /gene_synonym="uS19m" /coded_by="NM_001183214.3:1..276" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit; has similarity to E. coli S19 ribosomal protein" /db_xref="GeneID:855773" /db_xref="SGD:S000005320" ORIGIN 1 mqpaarllsr svwkgpnivp lpireamtkg tpirtnaraa tilpqfvglk fqihngkeyv 61 pieisedmvg hklgefaptr krfsytqtkn k // LOCUS NP_014436 629 aa linear PLN 30-JUN-2025 DEFINITION putative ATP-dependent RNA helicase DBP6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014436 VERSION NP_014436.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183215.1 REFERENCE 1 (residues 1 to 629) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 629) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 629) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 629) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10580. Method: conceptual translation. FEATURES Location/Qualifiers source 1..629 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..629 /product="putative ATP-dependent RNA helicase DBP6" /EC_number="3.6.4.13" /calculated_mol_wt="70231" Region 185..402 /region_name="DEADc_DDX51" /note="DEAD-box helicase domain of DEAD box protein 51; cd17956" /db_xref="CDD:350714" Site order(193..194,196..198,201,235..242) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350714" Region <450..572 /region_name="SF2_C_DEAD" /note="C-terminal helicase domain of the DEAD box helicases; cd18787" /db_xref="CDD:350174" Site order(531,533,558,561..562) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350174" CDS 1..629 /gene="DBP6" /locus_tag="YNR038W" /coded_by="NM_001183215.1:1..1890" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9528757]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17145778|PMID:15126390]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9528757]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9528757]" /note="Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family; human homolog DDX51 complements yeast dbp6 mutant" /db_xref="GeneID:855774" /db_xref="SGD:S000005321" ORIGIN 1 mfasrfdpsq ltapaasape givgttppai vplkrqates dneeygshqd sdessnssse 61 ededrmqvdy gaseedssev eeeeskpsth stvlsrfkqt vslqerlgas diaeskedeg 121 iedeaasthq lkqipqpefv knpmnlntns lqfkstgwln tekiyydnsl ikpfsdyane 181 leakllqnic knfstntfpi qsiildsilp vlnftlnvsk rnftrrigdi lvnaatgsgk 241 tlaysipivq tlfkrqinrl rciiivptkl linqvyttlt kltqgtsliv siaklenslk 301 dehkklsnle pdilittpgr lvdhlnmksi nlknlkflii deadrllnqs fqgwcpklms 361 hlktdkldtl pgnvikmifs atlttntekl nglnlykpkl flkqtdklyq lpnklnefni 421 niptaksvyk plillysicq fmahspiaak ilifvksnes sirlskllql icesrsqssv 481 lknlqnlavs insvnsnnsk aenkkivanf shhsesagit ilittdimsr gidinditqv 541 inydppmssq qyvhrvgrta ranelgsayn llvgrgertf fddlnkdldr dgksvqplel 601 dftllesdse lytssleslk nyhnntaqa // LOCUS NP_014437 605 aa linear PLN 30-JUN-2025 DEFINITION Zn(2+) transporter ZRG17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014437 VERSION NP_014437.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183216.1 REFERENCE 1 (residues 1 to 605) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 605) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 605) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 605) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 605) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10581. Method: conceptual translation. FEATURES Location/Qualifiers source 1..605 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..605 /product="Zn(2+) transporter ZRG17" /calculated_mol_wt="67330" CDS 1..605 /gene="ZRG17" /locus_tag="YNR039C" /coded_by="NM_001183216.1:1..1818" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:15961382|PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0005385 zinc ion transmembrane transporter activity [PMID:15961382]" /experiment="EXISTENCE:genetic interaction:GO:0006829 zinc ion transport [PMID:15961382]" /experiment="EXISTENCE:mutant phenotype:GO:0005385 zinc ion transmembrane transporter activity [PMID:15961382]" /experiment="EXISTENCE:mutant phenotype:GO:0006829 zinc ion transport [PMID:15961382|PMID:10978274]" /note="Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency" /db_xref="GeneID:855775" /db_xref="SGD:S000005322" ORIGIN 1 metpqmnaiq eednlspeva fqtpklndsd assfslsnmn avgnvdgips qnrtffaspr 61 psslfysake gnnssssiiy npsftfgena ssnanineaa lmkgkgnegr rqslkyipap 121 klvpppprtr spvrgispda gsskrssmtl dspfnfttst lqphqqtpps saasrtsfrk 181 ghrykhssvs mnffqepevk iplniakslp ipdfndllsn lpwpkayiql siaalqifac 241 litfqvghly swsnfitlsh fitydiigsl viifvenlsq fqvwftgtit fpfglnridv 301 llsfalavsl cfvgldllfh iieefivlfv esgssltnnh dhdeineqip hshianands 361 qnenitlwys ilminlvlst lslyktfyan kysnlktknp iititytayl fiypllldll 421 ssisdylatl visslilwhg ltiarwtstv llmgfsttsl snsalfnnnd stdttahtqq 481 veskaakekp svrprsmssl piatkntkir ktgflnsagf tenpttiknm ikdqierlse 541 fksryilnyd diviskvnft lyvvlikitm kggsdddelm lrlaidkciq tsiptcetti 601 didri // LOCUS NP_014438 256 aa linear PLN 30-JUN-2025 DEFINITION Mrx15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014438 VERSION NP_014438.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183217.3 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10582. On Jul 30, 2012 this sequence version replaced NP_014438.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..256 /product="Mrx15p" /calculated_mol_wt="28505" CDS 1..256 /gene="MRX15" /locus_tag="YNR040W" /gene_synonym="DPI29" /coded_by="NM_001183217.3:1..771" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:30091672]" /experiment="EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:30091672]" /experiment="EXISTENCE:genetic interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:30091672]" /experiment="EXISTENCE:mutant phenotype:GO:0097177 mitochondrial ribosome binding [PMID:30091672]" /note="Membrane-associated mitoribosome receptor; involved along with Mba1p in the cotranslational insertion of nascent polypeptide chains into the inner mitochondrial membrane; associates with the mitochondrial large ribosomal subunit and nascent polypeptide chains; null mutant displays increased tolerance to mistranslation-induced proteotoxic stress; localizes to the inner mitochondrial membrane" /db_xref="GeneID:855776" /db_xref="SGD:S000005323" ORIGIN 1 mtnmaaknqf kgssftlaql ieevgrnggk kpvfqykvpr sirwastala vvfltygaay 61 tdmswrtare vygnateeek hspwfkcktf gpvalgvlpv ilaaatkhvt srlvtemkyl 121 pplknstvpr cqltrrtyll grpvsitrei nelsknkatk iftgvgsqgm edkatfvfft 181 vdekapsffn kfyifsrsgs vvkndarild cffnsvaenk llnrsiltqi lshtsaktlf 241 hsgnsrssik nivkpk // LOCUS NP_014439 372 aa linear PLN 30-JUN-2025 DEFINITION 4-hydroxybenzoate octaprenyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014439 VERSION NP_014439.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183218.3 REFERENCE 1 (residues 1 to 372) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 372) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 372) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 372) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10583. On Jul 30, 2012 this sequence version replaced NP_014439.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..372 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..372 /product="4-hydroxybenzoate octaprenyltransferase" /EC_number="2.5.1.39" /calculated_mol_wt="40871" Region 80..365 /region_name="ubiA_proteo" /note="4-hydroxybenzoate polyprenyl transferase, proteobacterial; TIGR01474" /db_xref="CDD:130539" CDS 1..372 /gene="COQ2" /locus_tag="YNR041C" /coded_by="NM_001183218.3:1..1119" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10469659|PMID:1740455|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:359053]" /experiment="EXISTENCE:genetic interaction:GO:0006744 ubiquinone biosynthetic process [PMID:15548532]" /experiment="EXISTENCE:genetic interaction:GO:0008412 4-hydroxybenzoate polyprenyltransferase activity [PMID:7765507]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:1740455]" /experiment="EXISTENCE:mutant phenotype:GO:0008412 4-hydroxybenzoate polyprenyltransferase activity [PMID:1740455]" /note="Para hydroxybenzoate polyprenyl transferase; catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis; human COQ2, mutations in which are implicated in an increased risk of mutiple-system atrophy, can complement a yeast coq2 null mutant" /db_xref="GeneID:855778" /db_xref="SGD:S000005324" ORIGIN 1 mfiwqrksil lgrsilgsgr vtvagiigss rkrytsssss ssspsskesa pvftskelev 61 arkerldglg pfvsrlpkkw ipyaelmrle kpvgtwllyl pcswsilmga mmqgatlsat 121 agmlgifgvg alvmrgagct indfldrkld qrvirsverp iasgrvsprr alvflgaqtl 181 vgmgvlsllp aqcwwlglas lpivftyplf krftyypqaa lsacfnwgal lgfpamgvms 241 wptmiplyls sylwcmtydt iyahqdkkfd ikagikstal awgprtksim kamsasqial 301 lavaglnsgl lwgpgfiggl gvfayrlfsm ikkvdldnpk ncwkyfnani ntglyftyal 361 avdyilrlfg fl // LOCUS NP_014441 396 aa linear PLN 30-JUN-2025 DEFINITION diphosphomevalonate decarboxylase MVD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014441 VERSION NP_014441.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183220.1 REFERENCE 1 (residues 1 to 396) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 396) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 396) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 396) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10584. Method: conceptual translation. FEATURES Location/Qualifiers source 1..396 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..396 /product="diphosphomevalonate decarboxylase MVD1" /EC_number="4.1.1.33" /calculated_mol_wt="43985" Region 6..328 /region_name="mevDPdecarb" /note="diphosphomevalonate decarboxylase; TIGR01240" /db_xref="CDD:130307" CDS 1..396 /gene="MVD1" /locus_tag="YNR043W" /gene_synonym="ERG19" /coded_by="NM_001183220.1:1..1191" /experiment="EXISTENCE:direct assay:GO:0004163 diphosphomevalonate decarboxylase activity [PMID:8626466|PMID:15169949]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:8626466]" /experiment="EXISTENCE:mutant phenotype:GO:0004163 diphosphomevalonate decarboxylase activity [PMID:15169949|PMID:1779710]" /experiment="EXISTENCE:mutant phenotype:GO:0016126 sterol biosynthetic process [PMID:9244250]" /note="Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer" /db_xref="GeneID:855779" /db_xref="SGD:S000005326" ORIGIN 1 mtvytasvta pvniatlkyw gkrdtklnlp tnssisvtls qddlrtltsa atapeferdt 61 lwlngephsi dnertqnclr dlrqlrkeme skdaslptls qwklhivsen nfptaaglas 121 saagfaalvs aiaklyqlpq stseisriar kgsgsacrsl fggyvawemg kaedghdsma 181 vqiadssdwp qmkacvlvvs dikkdvsstq gmqltvatse lfkeriehvv pkrfevmrka 241 ivekdfatfa ketmmdsnsf hatcldsfpp ifymndtskr iiswchtinq fygetivayt 301 fdagpnavly ylaenesklf afiyklfgsv pgwdkkftte qleafnhqfe ssnftareld 361 lelqkdvarv iltqvgsgpq etneslidak tglpke // LOCUS NP_014442 725 aa linear PLN 30-JUN-2025 DEFINITION Aga1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014442 VERSION NP_014442.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183221.1 REFERENCE 1 (residues 1 to 725) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 725) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 725) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 725) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 725) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10585. Method: conceptual translation. FEATURES Location/Qualifiers source 1..725 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..725 /product="Aga1p" /calculated_mol_wt="73223" CDS 1..725 /gene="AGA1" /locus_tag="YNR044W" /coded_by="NM_001183221.1:1..2178" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:2072914|PMID:7957044]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000752 agglutination involved in conjugation with cellular fusion [PMID:7957044|PMID:2072914]" /experiment="EXISTENCE:mutant phenotype:GO:0050839 cell adhesion molecule binding [PMID:7957044|PMID:2072914]" /note="Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; AGA1 has a paralog, FIG2, that arose from the whole genome duplication" /db_xref="GeneID:855780" /db_xref="SGD:S000005327" ORIGIN 1 mtlsfahfty lftillgltn ialasdpeti lvtitktnda ngvvtttvsp alvststivq 61 agtttlyttw cpltvstssa aeispsisya ttlsrfstlt lstevcshea cpssstlptt 121 tlsvtskfts yicptchtta isslsevgtt tvvsssaiep ssasiispvt stlssttssn 181 ptttslssts tspsststsp sststsssst stsssststs ssststspss tstsssltst 241 sssststsqs ststssssts tspsststss sststspssk stsasststs syststspsl 301 tsssptlast spsstsisst ftdstsslgs siassstsvs lyspstpvys vpstssnvat 361 psmtsstvet tvssqsssey itkssistti psfsmstyft tvsgvttmyt twcpyssese 421 tstltsmhet vttdatvcth escmpsqtts litssikmst knvatsvsts tvessyacst 481 caetshsyss vqtassssvt qqttstkswv ssmttsdedf nkhatgkyhv tssgtstist 541 svseatstss idsesqeqss hllstsvlss sslsatlssd stillfssvs slsveqspvt 601 tlqisstsei lqptsstaia tisastssls atsistpsts vestiesssl tptvssifls 661 sssapsslqt svtttevstt sisiqyqtss mvtisqymgs gsqtrlplgk lvfaimavac 721 nvifs // LOCUS NP_014443 489 aa linear PLN 30-JUN-2025 DEFINITION Pet494p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014443 VERSION NP_014443.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183222.3 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10586. On Jul 30, 2012 this sequence version replaced NP_014443.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..489 /product="Pet494p" /calculated_mol_wt="57357" CDS 1..489 /gene="PET494" /locus_tag="YNR045W" /coded_by="NM_001183222.3:1..1470" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8389363]" /experiment="EXISTENCE:mutant phenotype:GO:0045182 translation regulator activity [PMID:2833749]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:2833749]" /note="Mitochondrial translational activator specific for the COX3 mRNA; acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane" /db_xref="GeneID:855781" /db_xref="SGD:S000005328" ORIGIN 1 mhlkkgkrsi stvwrllwkr fysvnsktnm hfsrsrkkpv tnftrtngll lscngdtfpy 61 lrtlwryfna pgnlmfvttn ivafmgivty ntlvtisser afeeqmmaaq vslakqreel 121 ettalslprd ielrgeeddi kweqpdvahv redplveeqn akldtpikqy tlgdlilnkr 181 envtdydsqr akasifhmly aymlyrdviq pttmtqnnns eewrrevell tkgkevqgth 241 rridvfydlw nknfdkivts pekvqnfqlp nwskyptilk fictelhdns lktlgefkqf 301 ygkvrsnevk kllglwlydh sflfphniyd nrteedfydi lindsmqdnr ifqkyssivm 361 npynertqlf fpnvnspsvn kpvpsislet ytrllkgyin lqetgckydy ndnifklisi 421 lklncflqrn kkkhagptvr illprdedrs qilgtisqae krtcyqilsk nrdvvallkr 481 isdiqadss // LOCUS NP_014444 135 aa linear PLN 30-JUN-2025 DEFINITION RNA methylation protein TRM112 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014444 VERSION NP_014444.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183223.1 REFERENCE 1 (residues 1 to 135) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 135) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 135) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 135) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 135) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10587. Method: conceptual translation. FEATURES Location/Qualifiers source 1..135 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..135 /product="RNA methylation protein TRM112" /calculated_mol_wt="14935" Region 2..130 /region_name="Trm112-like" /note="eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins; cd21089" /db_xref="CDD:411041" Site order(2,5,7..10,12,23,43,46,49,53,55,123,125..129) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:411041" CDS 1..135 /gene="TRM112" /locus_tag="YNR046W" /coded_by="NM_001183223.1:1..408" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14690591|PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591|PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008276 protein methyltransferase activity [PMID:17008308]" /experiment="EXISTENCE:direct assay:GO:0018364 peptidyl-glutamine methylation [PMID:17008308]" /experiment="EXISTENCE:direct assay:GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity [PMID:15899842]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22956767]" /experiment="EXISTENCE:mutant phenotype:GO:0016435 rRNA (guanine) methyltransferase activity [PMID:22493060]" /experiment="EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:15899842]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:22956767]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:22956767]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:22956767]" /experiment="EXISTENCE:mutant phenotype:GO:0070476 rRNA (guanine-N7)-methylation [PMID:22493060]" /experiment="EXISTENCE:mutant phenotype:GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity [PMID:15899842]" /experiment="EXISTENCE:physical interaction:GO:0035657 eRF1 methyltransferase complex [PMID:17008308]" /experiment="EXISTENCE:physical interaction:GO:0043528 tRNA (m2G10) methyltransferase complex [PMID:15899842]" /note="Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; N7-methylates G1575 of 18S rRNA as complex with Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress; functional homolog of human TRMT112" /db_xref="GeneID:855782" /db_xref="SGD:S000005329" ORIGIN 1 mkflttnflk csvkacdtsn dnfplqydgs kcqlvqdesi efnpefllni vdrvdwpavl 61 tvaaelgnna lpptkpsfps siqeltdddm ailndlhtll lqtsiaegem kcrncghiyy 121 ikngipnlll pphlv // LOCUS NP_014445 893 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase FPK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014445 VERSION NP_014445.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183224.1 REFERENCE 1 (residues 1 to 893) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 893) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 893) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 893) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10588. Method: conceptual translation. FEATURES Location/Qualifiers source 1..893 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..893 /product="serine/threonine protein kinase FPK1" /EC_number="2.7.11.1" /calculated_mol_wt="100416" Region 494..797 /region_name="STKc_phototropin_like" /note="Catalytic domain of Phototropin-like Serine/Threonine Kinases; cd05574" /db_xref="CDD:270726" Site order(502..506,510,523,525,557,573..574,576,580,582,621, 623,625..626,628,638..639,642,677..682,709,715,718) /site_type="active" /db_xref="CDD:270726" Site order(502..506,510,523,525,557,574..576,580,621,623, 625..626,628,638..639) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270726" Site order(506,580,582,621,623,625,642,677..682,709,715,718) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:270726" Site order(638..648,674..682) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270726" CDS 1..893 /gene="FPK1" /locus_tag="YNR047W" /coded_by="NM_001183224.1:1..2682" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:18199685]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:29895620|PMID:19966303|PMID:28069741]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18199685|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19966303]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:25378585]" /experiment="EXISTENCE:genetic interaction:GO:0001932 regulation of protein phosphorylation [PMID:28069741]" /experiment="EXISTENCE:genetic interaction:GO:0004674 protein serine/threonine kinase activity [PMID:19966303]" /experiment="EXISTENCE:genetic interaction:GO:0061092 positive regulation of phospholipid translocation [PMID:18199685]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:11337509]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:19966303]" /experiment="EXISTENCE:mutant phenotype:GO:2000370 positive regulation of clathrin-dependent endocytosis [PMID:28069741]" /note="Ser/Thr protein kinase; phosphorylates several aminophospholipid translocase family members, regulating phospholipid translocation and membrane asymmetry; phosphorylates and inhibits the protein kinase Akl1p, stimulating endocytosis; phosphorylates and inhibits upstream inhibitory kinase Ypk1p; localizes to the cytoplasm, early endosome/TGN, the plasma membrane and the shmoo tip; redundant role with KIN82 in the mating pheromone response; activity stimulated by Gin4p kinase and sphingolipid MIPC" /db_xref="GeneID:855783" /db_xref="SGD:S000005330" ORIGIN 1 maghhheheq erdheqeheh dslqrpttgs ertrsisfsk lltrswkrna sssnnmsvss 61 vnlysdpens resdhnnsgs egqssrfskl ksmfqsgnss knasahnssq sslegdsass 121 ssklryvkpm tsvanaspas pplsptipet dvlqtpkmvh idqhehereh sncgspimls 181 sssfsptvar tgtgrrrsps tpimpsqnsn nssstsairp nnyrhhsgsq gfssnnpfre 241 ragtvrssnp yfayqglpth amsshdldeg fqpyangsgi hflstptskt nsltntknls 301 nlslneiken eevqefnned fffhdipkdl slkdtlngsp srgsskspti tqtfpsiivg 361 fdneyeednn ndkhdekeeq qtttdnktrn lsptkqngka thprikiplr raasepnglq 421 lasatsptss sarktsgssn indkipgqsv pppnsffpqe pspkisdfpe prrsrrlrtk 481 sfsnkfqdim vgpqsfekir llgqgdvgkv flvrekktnr vyalkvlskd emikrnkikr 541 vlteqeilat snhpfivtly hsfqsedyly lcmeycmgge ffralqtrkt kciceddarf 601 yasevtaale ylhllgfiyr dlkpenillh qsghimlsdf dlsiqakdsk vpvvkgsaqs 661 tlvdtkicsd gfrtnsfvgt eeyiapevir gnghtaavdw wtlgiliyem lfgftpfkgd 721 ntnetftnil knevsfpnnn eisrtckdli kklltknesk rlgckmgaad vkkhpffkkv 781 qwsllrnqep plipvlsedg ydfaklssnk krqtsqdshk hldeqeknmf eerveyddev 841 seddpfhdfn smslmeqdnn smiygntnsy gkiaytpnsn rsrsnshrtf fkr // LOCUS NP_014446 393 aa linear PLN 30-JUN-2025 DEFINITION putative aminophospholipid translocase regulatory protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_014446 VERSION NP_014446.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183225.3 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10589. On Jul 30, 2012 this sequence version replaced NP_014446.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..393 /product="putative aminophospholipid translocase regulatory protein" /calculated_mol_wt="44411" Region 3..375 /region_name="CDC50" /note="Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal transduction mechanisms]; COG5035" /db_xref="CDD:227368" CDS 1..393 /locus_tag="YNR048W" /gene_synonym="CRF1" /coded_by="NM_001183225.3:1..1182" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0045332 phospholipid translocation [PMID:12842877]" /experiment="EXISTENCE:physical interaction:GO:0005802 trans-Golgi network [PMID:17093059]" /note="Potential noncatalytic subunit for phospholipid translocase Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication" /db_xref="GeneID:855784" /db_xref="SGD:S000005331" ORIGIN 1 mglilrwkek kqlsskqnaq ksrkpantsf rqqrlkawqp ilspqsvlpl lilmacvfap 61 igiglvvsti svqrlvvnyt ecdalapakh fetipseyvd yhfskkvavq pqwmvltdpe 121 lgnqtcriqf evpnhikkst yvyyrltnfn qnyreyvqsl dldqlkgkal igndldpncd 181 plrtvenkti fpcgliansm fndtfgttlt gvndtadyll ttkgiawdtd shrygkteyn 241 asdivpppnw aklfpngytd dnipdlqnwe qfkiwmrtaa lpnfyklamk netnglgkgi 301 yiadielnyp vrsfygtksf vlttnsiiga gnealgivyl ivagiatlfa ilflikvifk 361 prpmhdhsyl nfensdtpfd essvvsiplr eil // LOCUS NP_014447 210 aa linear PLN 30-JUN-2025 DEFINITION Mso1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014447 VERSION NP_014447.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183226.3 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10590. On Jul 30, 2012 this sequence version replaced NP_014447.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..210 /product="Mso1p" /calculated_mol_wt="23220" Region 31..70 /region_name="Mso1_Sec1_bdg" /note="Sec1-binding region of Mso1; pfam14475" /db_xref="CDD:433978" CDS 1..210 /gene="MSO1" /locus_tag="YNR049C" /coded_by="NM_001183226.3:1..633" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:16030256|PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16030256|PMID:16087665]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:16030256|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:22842922|PMID:16030256]" /experiment="EXISTENCE:direct assay:GO:0006904 vesicle docking involved in exocytosis [PMID:9207091]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:16087665]" /experiment="EXISTENCE:direct assay:GO:0033101 cellular bud membrane [PMID:16087665]" /experiment="EXISTENCE:mutant phenotype:GO:0006904 vesicle docking involved in exocytosis [PMID:9207091]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:16030256]" /experiment="EXISTENCE:mutant phenotype:GO:0061025 membrane fusion [PMID:16030256]" /note="Lipid-interacting protein in SNARE complex assembly machinery; acts at late step in secretion; interacts with membranes through two distinct binding sites; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; N-terminus closely associates with plasma membrane, C-terminus colocalizes with Sec4p on intracellular membranes; relocalizes from bud neck to nucleus upon DNA replication stress" /db_xref="GeneID:855785" /db_xref="SGD:S000005332" ORIGIN 1 mmsqvshsqe gsgrfwnkfk sstkslstsl ahlsikaekd gdtvnttlvh kglvkfyenq 61 hpfqgfpgwl gekedlpner kildtqvkhd mkkqnsrhfs psfsnrrkas sedpmgtpss 121 ngntpeytpa sksfqdiynn htssssatpr rassrptrps agqefraslg rsktsnsfnt 181 sstptpppda ssgvmamkdr lkrrnndygf // LOCUS NP_014448 446 aa linear PLN 30-JUN-2025 DEFINITION saccharopine dehydrogenase (NADP+, L-glutamate-forming) [Saccharomyces cerevisiae S288C]. ACCESSION NP_014448 VERSION NP_014448.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183227.1 REFERENCE 1 (residues 1 to 446) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 446) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 446) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 446) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10591. Method: conceptual translation. FEATURES Location/Qualifiers source 1..446 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..446 /product="saccharopine dehydrogenase (NADP+, L-glutamate-forming)" /EC_number="1.5.1.10" /calculated_mol_wt="48787" Region <2..445 /region_name="PLN02819" /note="lysine-ketoglutarate reductase/saccharopine dehydrogenase" /db_xref="CDD:215439" CDS 1..446 /gene="LYS9" /locus_tag="YNR050C" /gene_synonym="LYS13" /coded_by="NM_001183227.1:1..1341" /experiment="EXISTENCE:direct assay:GO:0004755 saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity [PMID:18416559]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0019878 lysine biosynthetic process via aminoadipic acid [PMID:6429126]" /note="Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112" /db_xref="GeneID:855786" /db_xref="SGD:S000005333" ORIGIN 1 mgknvlllgs gfvaqpvidt laanddinvt vacrtlanaq alakpsgska isldvtddsa 61 ldkvladndv vislipytfh pnvvksairt ktdvvtssyi spalrelepe ivkagitvmn 121 eigldpgidh lyavktidev hraggklksf lsycgglpap edsdnplgyk fswssrgvll 181 alrnsakywk dgkietvsse dlmatakpyf iypgyafvcy pnrdstlfkd lyhipeaetv 241 irgtlryqgf pefvkalvdm gmlkddanei fskpiawnea lkqylgakst skedliasid 301 skatwkdded rerilsgfaw lglfsdakit prgnaldtlc arleelmqye dnerdmvvlq 361 hkfgiewadg ttetrtstlv dygkvggyss maatvgypva iatkfvldgt ikgpgllapy 421 speindpimk elkdkygiyl kektva // LOCUS NP_014449 515 aa linear PLN 30-JUN-2025 DEFINITION Bre5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014449 VERSION NP_014449.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183228.1 REFERENCE 1 (residues 1 to 515) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 515) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 515) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 515) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10592. Method: conceptual translation. FEATURES Location/Qualifiers source 1..515 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..515 /product="Bre5p" /calculated_mol_wt="57543" Region 4..142 /region_name="NTF2" /note="Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many...; cd00780" /db_xref="CDD:238403" Site order(32,38,60,87,89..90,101,123,135..137,139,141) /site_type="active" /note="TAP/p15 interaction [active]" /db_xref="CDD:238403" Site order(36,38..39,84..85,87,89..90,99,103..105,109,111..114, 117,123,135..137,139..142) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238403" Site order(39..40,72,79,104,106,108..109,111,114,138,140,142) /site_type="active" /note="RanGDP-NTF2 interaction [active]" /db_xref="CDD:238403" Region 427..483 /region_name="RRM_SF" /note="RNA recognition motif (RRM) superfamily; cl17169" /db_xref="CDD:473069" CDS 1..515 /gene="BRE5" /locus_tag="YNR051C" /coded_by="NM_001183228.1:1..1548" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0045053 protein retention in Golgi apparatus [PMID:32673164]" /experiment="EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:12778054]" /experiment="EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:18391941]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:32673164]" /experiment="EXISTENCE:mutant phenotype:GO:0060628 regulation of ER to Golgi vesicle-mediated transport [PMID:12778054]" /experiment="EXISTENCE:mutant phenotype:GO:2000156 regulation of retrograde vesicle-mediated transport, Golgi to ER [PMID:14593109]" /experiment="EXISTENCE:physical interaction:GO:1990861 Ubp3-Bre5 deubiquitination complex [PMID:12778054]" /note="Ubiquitin protease cofactor; forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the ER and Golgi compartments, deubiquitinating COPII and COPI vesicle coat constituents, Sec23p and Sec27p; involved along with Ubp3p in the steady-state retention of Golgi membrane proteins, such as glycosyltransferases; null is sensitive to brefeldin A" /db_xref="GeneID:855787" /db_xref="SGD:S000005334" ORIGIN 1 mgvtvqdicf aflqnyyerm rtdpsklayf yastaeltht nyqskstnek ddvlptvkvt 61 greninkffs rndakvrslk lkldtidfqy tghlhksili matgemfwtg tpvykfcqtf 121 illpssngst fditndiirf isnsfkpyvl tdaslsqsne ensvsaveed kirhesgvek 181 ekekekspei skpkakketv kdttaptess tqekpivdhs qpraipvtke skihtetvps 241 stkgnhkqde vsteelgnvt klnekshkae kkaapiktke gsveainavn nsslpngkev 301 sdekpvpggv keaeteikpi epqvsdakes gnnastpsss pepvanppkm twasklmnen 361 sdrisknntt veyirpetlp kkpterkfem gnrrdnasan sknkkkpvfs tvnkdgfypi 421 yirgtnglre eklrsaleke fgkvmritaa dnfavvdfet qksqidalek kkksidgiev 481 clerktvkkp tsnnppgift ngtrshrkqp lkrkd // LOCUS NP_014450 433 aa linear PLN 30-JUN-2025 DEFINITION CCR4-NOT core DEDD family RNase subunit POP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014450 VERSION NP_014450.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183229.3 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10593. On Jul 30, 2012 this sequence version replaced NP_014450.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..433 /product="CCR4-NOT core DEDD family RNase subunit POP2" /EC_number="3.1.13.4" /calculated_mol_wt="49551" Region 141..433 /region_name="POP2" /note="mRNA deadenylase subunit [RNA processing and modification]; COG5228" /db_xref="CDD:227553" CDS 1..433 /gene="POP2" /locus_tag="YNR052C" /gene_synonym="CAF1" /coded_by="NM_001183229.3:1..1302" /experiment="EXISTENCE:direct assay:GO:0000175 3'-5'-RNA exonuclease activity [PMID:11410650]" /experiment="EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11410650|PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:18611963]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0030015 CCR4-NOT core complex [PMID:10490603]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:mutant phenotype:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11410650]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:11404327]" /note="Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation; exonuclease of the DEDD superfamily" /db_xref="GeneID:855788" /db_xref="SGD:S000005335" ORIGIN 1 mqsmnvqprv lavggeqffs qrqaseqhqq qnmgpqvysp kvnrarmfpq gmpvntings 61 vnqemnnayl lkqknepllt qqqqqqqqqq qpfnigtpvs vaslppglnv lqqqqqqqqq 121 qqqqqqgvgl nrplasqlpk hltnqsmppi flpppnylfv rdvwksnlys efavirqlvs 181 qynhvsiste fvgtlarpig tfrskvdyhy qtmranvdfl npiqlglsls dangnkpdng 241 pstwqfnfef dpkkeimste slellrksgi nfekhenlgi dvfefsqllm dsglmmddsv 301 twityhaayd lgflinilmn dsmpnnkedf ewwvhqympn fydlnlvyki iqefknpqlq 361 qssqqqqqqq yslttladel glprfsiftt tggqsllmll sfcqlsklsm hkfpngtdfa 421 kyqgviygid gdq // LOCUS NP_014451 486 aa linear PLN 30-JUN-2025 DEFINITION putative GTPase NOG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014451 VERSION NP_014451.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183230.1 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10594. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..486 /product="putative GTPase NOG2" /calculated_mol_wt="55358" Region 41..171 /region_name="NGP1NT" /note="NGP1NT (NUC091) domain; pfam08153" /db_xref="CDD:462379" Region 214..370 /region_name="NGP_1" /note="A novel nucleolar GTP-binding protein, circularly permuted subfamily of the Ras GTPases; cd01858" /db_xref="CDD:206751" Site order(260..261,263..264,289..291,324..330,369) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206751" Site 260..263 /site_type="other" /note="G4 box" /db_xref="CDD:206751" Site 289..291 /site_type="other" /note="G5 box" /db_xref="CDD:206751" Site 322..329 /site_type="other" /note="G1 box" /db_xref="CDD:206751" Site 347..354 /site_type="other" /note="Switch I region" /db_xref="CDD:206751" Site 350 /site_type="other" /note="G2 box" /db_xref="CDD:206751" Site 366..369 /site_type="other" /note="G3 box" /db_xref="CDD:206751" Site 368..370 /site_type="other" /note="Switch II region" /db_xref="CDD:206751" CDS 1..486 /gene="NOG2" /locus_tag="YNR053C" /gene_synonym="NUG2" /coded_by="NM_001183230.1:1..1461" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:11707418]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11707418]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23212245|PMID:17443350|PMID:22735702]" /experiment="EXISTENCE:direct assay:GO:0070180 large ribosomal subunit rRNA binding [PMID:24240281]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11707418|PMID:11583615]" /experiment="EXISTENCE:mutant phenotype:GO:2000200 regulation of ribosomal subunit export from nucleus [PMID:24240281]" /note="Putative GTPase; associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation; recruited by ribosomal proteins L17, L35, and L37 to assembling ribosomes after 27SB pre-rRNA is generated, immediately preceding removal of ITS2" /db_xref="GeneID:855789" /db_xref="SGD:S000005336" ORIGIN 1 mgtgkkeksr riregdtkdg nlrvkgenfy rdskrvkfln mytsgkeirn kkgnliraas 61 fqdstipdar vqpdrrwfgn trvisqdalq hfrsalgetq kdtyqvllrr nklpmsllee 121 kdadespkar ildtesyada fgpkaqrkrp rlaasnledl vkatneditk yeekqvldat 181 lglmgnqedk engwtsaake aifskgqskr iwnelykvid ssdvvihvld ardplgtrck 241 sveeymkket phkhliyvln kcdlvptwva aawvkhlske rptlafhasi tnsfgkgsli 301 qllrqfsqlh tdrkqisvgf igypntgkss iintlrkkkv cqvapipget kvwqyitlmk 361 riflidcpgi vppsskdsee dilfrgvvrv ehvthpeqyi pgvlkrcqvk hlertyeisg 421 wkdatefiei larkqgrllk ggepdesgvs kqilndfnrg kipwfvlppe kegeekpkkk 481 evekta // LOCUS NP_014452 316 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding ATPase activator ESF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014452 VERSION NP_014452.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183231.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10595. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..316 /product="RNA-binding ATPase activator ESF2" /calculated_mol_wt="36277" Region 114..211 /region_name="RRM_ABT1_like" /note="RNA recognition motif (RRM) found in activator of basal transcription 1 (ABT1) and similar proteins; cd12263" /db_xref="CDD:409707" CDS 1..316 /gene="ESF2" /locus_tag="YNR054C" /gene_synonym="ABT1" /coded_by="NM_001183231.1:1..951" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:16772403]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:16772403]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:15964808]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15964808]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15964808]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15964808]" /experiment="EXISTENCE:mutant phenotype:GO:0034462 small-subunit processome assembly [PMID:15964808]" /note="Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome" /db_xref="GeneID:855790" /db_xref="SGD:S000005337" ORIGIN 1 msekvnsdfe dfssdeetdq hnvliqtkkk isskddifsk kvediesene sdieeeqkqe 61 ekedveqpdk engekldrev eeqassttsl dlkteklrql vkskaakksk hktgvvyfss 121 ippymkpakm rqiltrfgev drlflkkedd qkykqrvkgg gnkknkyeeg waefirkrda 181 klcaetlngn iiggkkgtfy hddilnvkyl pgfkwadlte qiarendirq aklemeisqa 241 nklnaefirn veqskmiqni knsrkragke gesadshphr efkqrrvets ranapsdikq 301 qssgskdlgn vltnll // LOCUS NP_014453 586 aa linear PLN 30-JUN-2025 DEFINITION Hol1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014453 VERSION NP_014453.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183232.3 REFERENCE 1 (residues 1 to 586) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 586) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 586) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 586) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10596. On Jul 30, 2012 this sequence version replaced NP_014453.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..586 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..586 /product="Hol1p" /calculated_mol_wt="65217" Region 67..569 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(77..78,81..82,85,117,167..168,170..172,175,195, 198..199,202,376,379..380,383..385,388,413,417,489..490, 494,498,512,515..516,519..520,523) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..586 /gene="HOL1" /locus_tag="YNR055C" /coded_by="NM_001183232.3:1..1761" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006812 monoatomic cation transport [PMID:8955402]" /experiment="EXISTENCE:mutant phenotype:GO:0015203 polyamine transmembrane transporter activity [PMID:34375581]" /experiment="EXISTENCE:mutant phenotype:GO:0015665 alcohol transmembrane transporter activity [PMID:2405251]" /experiment="EXISTENCE:mutant phenotype:GO:0015850 organic hydroxy compound transport [PMID:2405251]" /experiment="EXISTENCE:mutant phenotype:GO:0022890 inorganic cation transmembrane transporter activity [PMID:8955402]" /experiment="EXISTENCE:mutant phenotype:GO:1902047 polyamine transmembrane transport [PMID:34375581]" /note="Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake" /db_xref="GeneID:855792" /db_xref="SGD:S000005338" ORIGIN 1 mdkytnrdhp dyipgtfniy ssqnlengii yesklkktss gvvlipqpsy spndplnwss 61 wrklahfglm afitaftaat sndagaaqds lneiygisyd smntgagvlf lgigwstlfl 121 apfanlygrk ityivcttlg lfgalwfala krtsdtiwsq lfvgisesca eaqvqlslsd 181 iffqhqlgsv ltvyimctsi gtflgpliag yisaftnfrw vgwvaviisg gllitiifgc 241 eetyfdrgqy mtpltscqsg yedgttlqns dntavsrrkr hldaklstpg amgekgvdls 301 etaefevnne eevtipetre lidgskehlk pypkrvailt katnlkgygf kqyfkylkin 361 lrmflfppvw lsgmfwgiqd vfltfylttq esayyeppwn ysdfgvaimn vptligavig 421 cicagivsdy fvlwmarhnr gileaefrly fsiataiigp agllmfgigt arqwpwqaiy 481 vglgfvgfaw gcsgdiamay lmdcypdmvl egmvctaiin ntisciftft csdwlaasgt 541 entyialavi nfgitafalp myyygkrirl wtkrwylqsv nlrdgv // LOCUS NP_014454 561 aa linear PLN 30-JUN-2025 DEFINITION Bio5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014454 VERSION NP_014454.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183233.3 REFERENCE 1 (residues 1 to 561) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 561) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 561) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 561) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 561) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10597. On Jul 30, 2012 this sequence version replaced NP_014454.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..561 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..561 /product="Bio5p" /calculated_mol_wt="62297" Region 38..555 /region_name="AA_permease_2" /note="Amino acid permease; cl45918" /db_xref="CDD:459263" CDS 1..561 /gene="BIO5" /locus_tag="YNR056C" /coded_by="NM_001183233.3:1..1686" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0022857 transmembrane transporter activity [PMID:10333520]" /experiment="EXISTENCE:direct assay:GO:0051180 vitamin transport [PMID:10333520]" /experiment="EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:10333520]" /experiment="EXISTENCE:mutant phenotype:GO:0051180 vitamin transport [PMID:10333520]" /note="Putative transmembrane protein involved in the biotin biosynthesis; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis" /db_xref="GeneID:855793" /db_xref="SGD:S000005339" ORIGIN 1 mnrvgavflf vyernfflsi vpdrhrteir msssersevk fdkhfnwwsl lgiafslscs 61 wvgisasmav giasggplli iygliiaaff slmcgislgd faailpnssg gsfwvlkmle 121 qesvtlktpe yedpsdddee vflenycqtf nvevsskfqk vssmvvglln yfgaifttas 181 icsslsmsci gihkllhpdy elkhwhvfvg yecinavltl fniystplpy isqfglytsl 241 lsfamtfiic ivsrsdntvd pwpkasnifg sfdnqtgwns sgmafvvglv npiwafvgid 301 sathmidevg ysksrflvpk viittiivgf vtsfiycvgl ffcitdqtav vesilpivei 361 fyqatgnrnl svflqcmcit tgfvsgiasg twqsrilqsf gksyapfyke gslgnkslkk 421 lavltpgfks plyahflsqi cvtiigcifm gsstafnaii tacitlllms yavpsfiflf 481 vikkekfihr iesdvncvsr pnrrrmsmip hiicilwtlf clvflsfpyt lpvtagnmny 541 tsvvyavvfc iisivvfptc i // LOCUS NP_014455 237 aa linear PLN 30-JUN-2025 DEFINITION dethiobiotin synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014455 VERSION NP_014455.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183234.1 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10598. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..237 /product="dethiobiotin synthase" /EC_number="6.3.3.3" /calculated_mol_wt="26126" Region 15..186 /region_name="bioD" /note="dethiobiotin synthase; TIGR00347" /db_xref="CDD:129447" Site order(19..21,82..84,87,120..124,134,158..159,162..163, 165..167,169..170,199) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:349763" Site order(21..27,42,46,54,83..84,117,119..120,124,186..187) /site_type="active" /db_xref="CDD:349763" CDS 1..237 /gene="BIO4" /locus_tag="YNR057C" /coded_by="NM_001183234.1:1..714" /experiment="EXISTENCE:direct assay:GO:0004141 dethiobiotin synthase activity [PMID:10333520]" /experiment="EXISTENCE:direct assay:GO:0009102 biotin biosynthetic process [PMID:10333520]" /experiment="EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:10333520]" /note="Dethiobiotin synthetase; catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria; expression appears to be repressed at low iron levels" /db_xref="GeneID:855794" /db_xref="SGD:S000005340" ORIGIN 1 mnsksqqqeq qpivfvtgtd tdvgktfvst llvhkwkaay wkpvqtgies dqgdsetlkn 61 fkiaastwqp piftptyalq kplsplqame yepnvdirll dfvvpeewsa enplvvegag 121 gvcvpitrkl eittdlikhl ietsghpvyv vvvarsglgt lnhtlltwnh lcdnglrshl 181 fgvilngepn egnvqalkkf gvnimaqvaq cttahdqdme lhelpsvesl mtqqdve // LOCUS NP_014456 480 aa linear PLN 30-JUN-2025 DEFINITION adenosylmethionine-8-amino-7-oxononanoate transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014456 VERSION NP_014456.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183235.1 REFERENCE 1 (residues 1 to 480) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 480) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 480) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 480) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 480) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10599. Method: conceptual translation. FEATURES Location/Qualifiers source 1..480 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..480 /product="adenosylmethionine-8-amino-7-oxononanoate transaminase" /EC_number="2.6.1.62" /calculated_mol_wt="53578" Region 15..472 /region_name="AAT_I" /note="Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; cl18945" /db_xref="CDD:450240" Site order(125..127,160..161,163,236,270,272..273,314) /site_type="active" /note="inhibitor-cofactor binding pocket [active]" /db_xref="CDD:99735" Site order(126..127,160..161,236,270,273,314) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99735" Site 314 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99735" CDS 1..480 /gene="BIO3" /locus_tag="YNR058W" /coded_by="NM_001183235.1:1..1443" /experiment="EXISTENCE:direct assay:GO:0004015 adenosylmethionine-8-amino-7-oxononanoate transaminase activity [PMID:10333520]" /experiment="EXISTENCE:direct assay:GO:0009102 biotin biosynthetic process [PMID:10333520]" /experiment="EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:10333520]" /note="7,8-diamino-pelargonic acid aminotransferase (DAPA); catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; BIO3 and BIO4 were acquired by horizontal gene transfer (HGT) from bacteria" /db_xref="GeneID:855795" /db_xref="SGD:S000005341" ORIGIN 1 msqeisytpd vaelldfdkk hiwhpytsls splnvypvks ahgcklvldt dspvdvevid 61 amsswwcvih gynnpelnea ltkqmlkfsh vllggfthkg avnlvqkllk videpslqyc 121 fladsgsvav evalkmalqs nmsgeatknr tkfltikngy hgdtfgamsv cdpensmhhi 181 yndrlsenif aqapsivdgl ptsqngfedh wnaeevtdlk kqfelhsdki cavilepilq 241 gagglrpyhp qflievqklc nqydvlfimd eiatgfgrtg eifafkhcqk yqdqhgisps 301 dqikvvpdil cvgkgltsgy mtmsavvvnd kvasrisspn sptggcfmhg ptfmgnalac 361 svaeksmdil lrgewrkqvs aienqiyrel yqyiknpdng ligtvvkrvs vigavgivel 421 ykktdpewfq kkfiskgvhi rpfnclcyim ppyvitteel tkvnqvliev lhewkshinq // LOCUS NP_014457 580 aa linear PLN 30-JUN-2025 DEFINITION putative alpha-1,3-mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014457 VERSION NP_014457.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183236.3 REFERENCE 1 (residues 1 to 580) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 580) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 580) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 580) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 580) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10600. On Jul 30, 2012 this sequence version replaced NP_014457.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..580 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..580 /product="putative alpha-1,3-mannosyltransferase" /calculated_mol_wt="67951" Region 197..472 /region_name="Mannosyl_trans3" /note="Mannosyltransferase putative; pfam11051" /db_xref="CDD:402574" CDS 1..580 /gene="MNT4" /locus_tag="YNR059W" /coded_by="NM_001183236.3:1..1743" /experiment="EXISTENCE:curator inference:GO:0006493 protein O-linked glycosylation [PMID:10521541]" /note="Putative alpha-1,3-mannosyltransferase; not required for protein O-glycosylation; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /db_xref="GeneID:855796" /db_xref="SGD:S000005342" ORIGIN 1 mvlrirrikk lapliftsll slivlfrvyr qypfsdhfet rreddrsgnv hcfsrlrqie 61 eyekpeltsk fyepnrwksf isyvtrsrkd vktvsrslsn ldlyqkcske iradqdisll 121 hsietklfpy inftalnseq shnfwpvhtr fdgtkyrgqv lqfssennsf igtspiefka 181 sepfwenwln salqrnskgv vmsvseylva dtirlirvlr llnnslpiei vhksdlhess 241 qqlliaaare sgslnyppqe lwfldvkdml ndeylarfkr fsnkwlaitf csfqipifld 301 sdtvpfvpld tlyeidgfkr tgtlffkdrs fptsklsplq vkvlkqiinn sldvssdseq 361 gfeilkhnln demaidaiea lifkkqkhym dsglvifdkq khffclpiai mlqfspiqef 421 fhgdkewfwl slfiskkeft fypieasnvg rlekpetles sticstqlsh tdvygnllwl 481 ngglsvckkn cwnydftkrk eiaakyksvd elrnyyqspv kleaviipdv skspwsqqse 541 cvmysycthy rkgqygklie ftdsqkkyye kvvelwnkvv // LOCUS NP_014458 719 aa linear PLN 30-JUN-2025 DEFINITION ferric-chelate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014458 VERSION NP_014458.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183237.1 REFERENCE 1 (residues 1 to 719) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 719) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 719) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 719) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 719) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10601. Method: conceptual translation. FEATURES Location/Qualifiers source 1..719 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..719 /product="ferric-chelate reductase" /EC_number="1.16.1.9" /calculated_mol_wt="81885" Region 273..390 /region_name="Ferric_reduct" /note="Ferric reductase like transmembrane component; pfam01794" /db_xref="CDD:426438" Region 428..596 /region_name="NOX_Duox_like_FAD_NADP" /note="NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; cd06186" /db_xref="CDD:99783" Site order(457,472..475,489..491,495..498,540) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(472,474..475) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99783" Region 530..698 /region_name="NAD_binding_6" /note="Ferric reductase NAD binding domain; pfam08030" /db_xref="CDD:429792" Site 535..545 /site_type="other" /note="NAD pyrophosphate binding region [chemical binding]" /db_xref="CDD:99783" Site order(535,539..542,544) /site_type="other" /note="beta-alpha-beta stucture motif" /db_xref="CDD:99783" Site order(567..568,571) /site_type="other" /note="NADP ribose binding motif [chemical binding]" /db_xref="CDD:99783" CDS 1..719 /gene="FRE4" /locus_tag="YNR060W" /coded_by="NM_001183237.1:1..2160" /experiment="EXISTENCE:genetic interaction:GO:0000293 ferric-chelate reductase activity [PMID:11120744]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:11120744]" /experiment="EXISTENCE:mutant phenotype:GO:0015891 siderophore transport [PMID:11120744]" /note="Ferric reductase; reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" /db_xref="GeneID:855797" /db_xref="SGD:S000005343" ORIGIN 1 mllvhiisfl lffqlsaaka ppsktslint herrsiyscy vglrketwgf ngsaicryep 61 aiqsmlycly edthekgysn ktlekgfeem rqfcytpkfl nmtdaefyts ldngtyyiqd 121 qpkaginity pirlnttlrk ayydayygyy ynhdipyyfg giicayfvgv mllaglirfl 181 nytpikkimf qqklvnyvrg yttlptlyek haepfsylkv itgylptrfe tlvilgylil 241 htifmaykyq ydpyhiifaa hraevahfva yrsgilsfah lplivlfagr nnflqlisgl 301 khtsfivfhk wlgrmmflda iihaagftny ylyykkwntv rlrvywkfgi attclagmli 361 ffsiaafrrh yyetfmalhi vfaalflytc wehvtnfsgi ewiyaaiaiw gvdrivritr 421 iallgfpkad lqlvgsdlvr vtvkkpkkfw kakpgqyvfv sflrplcfwq shpftvmdsc 481 vndrelvivl kakkgvtklv rnfverkggk asmrlaiegp ygskstahrf dnvlllaggs 541 glpgpishal elgkttaasg knfvqlviav rgldmlnack kelmalkgln vqvhiynskq 601 elasaekiss nevkngetta ekapsslsns ekapsesent elplslndts isdlefatfh 661 vgrpnveeil nesvnhsgsl avvccgppif vdtarnqtak avirnpsrmi eyleeyqaw // LOCUS NP_014459 219 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNR061C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014459 VERSION NP_014459.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183238.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10602. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..219 /product="uncharacterized protein" /calculated_mol_wt="24186" Region 13..132 /region_name="MARVEL" /note="Membrane-associating domain; pfam01284" /db_xref="CDD:366555" CDS 1..219 /locus_tag="YNR061C" /coded_by="NM_001183238.1:1..660" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /note="hypothetical protein; relocalizes from vacuole to cytoplasm upon DNA replication stress" /db_xref="GeneID:855798" /db_xref="SGD:S000005344" ORIGIN 1 mlkltttsvt fhvlryfqlg lsvtnlllas faiitnykvd rilrlslavs iissvyfgiv 61 rflpvllifv meivqtvlwf tafvtlaskf gsmscssmpr ginfdysgsc kiakidilpe 121 avlfilflat tyasyitvls qakengsstr svlkacvkal rdtvdrlets leeseplldl 181 evqedartet esiedstdse dnanieqekv idgsiehss // LOCUS NP_014460 327 aa linear PLN 30-JUN-2025 DEFINITION Pul3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014460 VERSION NP_014460.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183239.3 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10603. On Jul 30, 2012 this sequence version replaced NP_014460.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..327 /product="Pul3p" /calculated_mol_wt="35528" CDS 1..327 /gene="PUL3" /locus_tag="YNR062C" /coded_by="NM_001183239.3:1..984" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Putative pulcherrimin transporter; involved in uptake of iron-transporting siderophore, pulcherrimin" /db_xref="GeneID:855799" /db_xref="SGD:S000005345" ORIGIN 1 msiaqdrgiv fkllsiyraa agifmalaql iviffgycdf kikgyriasy naptfassfi 61 ilavclllvv vlenpevkvt nsenslfsal kqffrverkk lisclillws mflssfimse 121 vvyfmplflt lhvnwdtkfq giafmvasil gvtgsyfapk linvgcscgr akdggleesd 181 ttgsetvevk kkdslysgqv flsifalfvs llgqafmiga sealkhksmp ptnsgiffsa 241 gmsitllgyn flassipalf smyidpklkv qlmpsigais gigklvapiv laalygtrlg 301 lsiavgfgmi lvavsippli wlrkkrc // LOCUS NP_014461 607 aa linear PLN 30-JUN-2025 DEFINITION Pul4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014461 VERSION NP_014461.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183240.3 REFERENCE 1 (residues 1 to 607) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 607) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 607) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 607) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 607) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10604. On Jul 30, 2012 this sequence version replaced NP_014461.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..607 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..607 /product="Pul4p" /calculated_mol_wt="69532" Region 10..47 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(15,20..23,25,28,37) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(16,19,26,32,35,44) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 184..575 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..607 /gene="PUL4" /locus_tag="YNR063W" /coded_by="NM_001183240.3:1..1824" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Putative zinc-cluster transcription factor; involved in utilization of iron-transporting siderophore pulcherrimin" /db_xref="GeneID:855800" /db_xref="SGD:S000005346" ORIGIN 1 mdrskdarkr sislactvcr krklkcdgnk pcgrcirlnt pkeciynidk rkdkrkikng 61 skvflfknnt idngnnsile nkglnedlss hiyekeapkf dsdidisrfg tndavifnnd 121 gwdtslpidf dfdefntett dfddflkllg dnspskeqks lsysptatgl sgvvketese 181 dnaptrsrli dvlfenklhs vpgiskwhly elesqypnle ctegnsdekf llstvlclgs 241 ltirkrelln hsnidnrpll pensiskltt dafkyynaak tlvpdllshp tidgfcglvl 301 manfmtmmis lehqlylsin alqlavalnl nnntkckell esnsdgigvi llfwniwcss 361 cmlatihgkn pfitleqitt plpceisprn ktnkllidfm qiriklatlq skifqrlyts 421 stanevpfvn lerefeevsl qitrlkgfpi feehlfyrsr vlmlelsclr aqasfllyrp 481 ylitgeslqa vtmaksiihe iwsqytkqfp dnekerherl dwnfcyplrt asltlcisci 541 illrykqvvq flkgtelfey ilaleilqdl vqvlpieqnl idiikypisp vqlsgdsfve 601 fwgrily // LOCUS NP_014462 290 aa linear PLN 30-JUN-2025 DEFINITION epoxide hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014462 VERSION NP_014462.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183241.1 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10605. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..290 /product="epoxide hydrolase" /calculated_mol_wt="32625" Region 30..275 /region_name="Abhydrolase_1" /note="alpha/beta hydrolase fold; pfam00561" /db_xref="CDD:395444" CDS 1..290 /locus_tag="YNR064C" /coded_by="NM_001183241.1:1..873" /experiment="EXISTENCE:direct assay:GO:0004301 epoxide hydrolase activity [PMID:15769598]" /experiment="EXISTENCE:direct assay:GO:0097176 epoxide metabolic process [PMID:15769598]" /note="Epoxide hydrolase; member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides" /db_xref="GeneID:855801" /db_xref="SGD:S000005347" ORIGIN 1 msniiarfhk iqvqdgvkvw yreagaagnp tilllhgfpt ssnmfrnlip llagqfhiia 61 pdlpgfgfte tpenykfsfd slcesigyll dtlsiekfam yifdygspvg frlalkfpsr 121 itgivtqngn ayeeglddrf wgplkeywks yqsdpvfvks lipyledpan vicqyhdgvp 181 aiesvdpaay tldialiqrt gqtdiqlrlf fdyqnnikly pafqkflrds kipvlvawga 241 ndtifsvaga eayrkdvdnl kvvyydtghf alethvvaia eeiismfaen // LOCUS NP_014463 1116 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNR065C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014463 VERSION NP_014463.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183242.1 REFERENCE 1 (residues 1 to 1116) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1116) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1116) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1116) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10606. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1116 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1116 /product="uncharacterized protein" /calculated_mol_wt="125069" Region <1..260 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" Region 295..922 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" CDS 1..1116 /locus_tag="YNR065C" /coded_by="NM_001183242.1:1..3351" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene" /db_xref="GeneID:855802" /db_xref="SGD:S000005348" ORIGIN 1 mlmtgsvgdg sefdwedqkt fisrdggltw rfvhnssgly atgdlgniiv yipydpeedg 61 dfqsefyysl dqgrtwneye ltnaissvhp yklinptpdg sgskfifkgt fattdsetns 121 itslkgveyi idfsaafdsr tceeedfedw dladgkcvng akykyrrrkq daqclvkkaf 181 kdlsldetpc nscgesdyec sfefvrdang lcipdynlia fsnicdkskd ksvlveplql 241 ikgdecktpm kiepvdipcd eipeegssdr eivttenkfd feikfyqyfd tvadeslvml 301 nsigdayish dggqtikrfd tngekivevv fnpyfnssay lfgskgnifs thdrghsfmi 361 aklpearqlg mpldfsakaq dtfiyyggkn cesilspech avayltkdgg etftemldna 421 ihcefagtlf eypsneemvm cqvkkksset rslvssidff qgdnkiifen iigylstggy 481 iivavphedn elrayvtidg tefaeakfpy gqdvskqeaf tilgsekgsi flhlatnles 541 ghdfgnllks nsngtsfvtl ehavnrntfg yvdfekvqgl egiiitnivs nrekvgenke 601 deqlktkitf ndgsdwnflk ppkkdsegkk fpcdsvsldk cslhlhgyte rkdirdtyss 661 gsalgmmfgv gnvgdkllpy eecstflttd ggetwtevkk gphqweygdh ggvlvlvpen 721 aetdsisyst dfgktwkdyk fcgdkvlvkd iitvprdsal rfllfgeakn mgsgsfrtyt 781 idfrniferq cefditgkkr adfkysplgs rtgclfghqt eflrktdekc figniplsef 841 srnvkncsct rqdfecdynf ykasdgtckl vkglssanga dickkepdli eyydssgyrk 901 iplstckggl kldahlaphp cpgkekafre kysintgaya lvfvtillvi ffaawfvydr 961 girrnggfsr feeirlgddg liennrtdrv vniivrlglc islitksafq rtkagvarfs 1021 sklrarfgnr kgptyssllq gqfsdesdgl hedandlssf tsqdsnfeie qedayrpeqe 1081 htsqidqpat snipdalpar saihkpdsta vrnede // LOCUS NP_014464 436 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNR066C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014464 VERSION NP_014464.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183243.3 REFERENCE 1 (residues 1 to 436) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 436) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 436) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 436) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10607. On Jul 30, 2012 this sequence version replaced NP_014464.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..436 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..436 /product="uncharacterized protein" /calculated_mol_wt="49524" Region 45..>434 /region_name="VPS10" /note="VPS10 domain; smart00602" /db_xref="CDD:214740" CDS 1..436 /locus_tag="YNR066C" /coded_by="NM_001183243.3:1..1311" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11935221]" /note="Putative membrane-localized hypothetical protein" /db_xref="GeneID:855803" /db_xref="SGD:S000005349" ORIGIN 1 millqvicti wtclfiplln aeefvpkvte tlseysfsle sfddsnslir ldnqvvwiss 61 dsgenweavk eieghileli vdplhgqdra fvsihlspkf yvtddrgksw raltipvsen 121 crlgtscsia thptdkkyli adcpcfindn gyiqiqnety ftndgesfyn iepslkkked 181 dhitssscnf vksskdsdie gndasilclf snhgydsdrh lsaaytqlal stdggktfkk 241 fdefndkiiy qykilkshii vstqddryne mspmdiwisn dastfqkarl paqvrhvhmy 301 giyedsigri iipistiftd ekndqpapse ilisdsqglk flpvewtinp hfgyidiasp 361 hflegtiigs fhpsfdyshn kgkynkkiar yetkisvdng ltwsnlkvvd eenadsfpcd 421 itrpercslq npfysi // LOCUS NP_014465 1117 aa linear PLN 30-JUN-2025 DEFINITION endo-1,3(4)-beta-glucanase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014465 VERSION NP_014465.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183244.1 REFERENCE 1 (residues 1 to 1117) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1117) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1117) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1117) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1117) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10608. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1117 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1117 /product="endo-1,3(4)-beta-glucanase" /EC_number="3.2.1.39" /calculated_mol_wt="120934" Region 420..744 /region_name="Glyco_hydro_81" /note="Glycosyl hydrolase family 81 N-terminal domain; pfam03639" /db_xref="CDD:427418" Region 753..1106 /region_name="Glyco_hydro81C" /note="Glycosyl hydrolase family 81 C-terminal domain; pfam17652" /db_xref="CDD:435946" CDS 1..1117 /gene="DSE4" /locus_tag="YNR067C" /gene_synonym="ENG1" /coded_by="NM_001183244.1:1..3354" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:27229769]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0030428 cell septum [PMID:12455695]" /experiment="EXISTENCE:genetic interaction:GO:0042973 glucan endo-1,3-beta-D-glucosidase activity [PMID:12455695]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:16328626]" /note="Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother" /db_xref="GeneID:855804" /db_xref="SGD:S000005350" ORIGIN 1 mqlyltllfl lsfvecsyis fisnnadeil etdlietlsy atltvgepyv aqsvvvtrvs 61 aashsplsvs pknrvsaspi nsqdsdsntr tavqlslsls nyasqvsqki saqtnndpvt 121 vsniyandns kskssvhnls svsgvasvmp sastmrkvtt llsqtastst stlfssslsi 181 sgtqlngtll tsvskgtidp lvtqmpsyss qetkiipssl tsnktiytis vrtnaatatg 241 edsfiastpa sstlfypsns tqdlvqtlas ttaspaypsn rtqitlspsv slysttspiy 301 psnitengss pspslsstvs pvypssstgn illsslfstv dsssspvsst ldtiyvsssm 361 qatissssss rqtktssssl ststsstatt tensstttiv nlfnavstde pptvfdrspn 421 pmsladgvsn dgpiqtnkfy tnlivgsqes pafvypyslw kytsssygfa vqhttvdqys 481 yggydssgna eylvnplgia hvvfsasnfd ssmtmqvdem tlsstrvvls esndssnyle 541 iplvqgmgfa tgiyhgslna kigssvgfnt ivsesssnla qgilkyritl lngvtwlcyv 601 igpddltstd fslevsseye ikasasvdgl iiqlavapse tdyevfydqa agmyvtnfkl 661 qgvsdgstat yefsyttqge sasgstmifa lphhessfsd imqdyytgiq lasttkgvmn 721 gylttslqfs tslnrqiswl pwssqlgsnl leyskeqlql laevanselq vsisesisgl 781 ntyylgkvid kysyilltvs eiiqdeastk stleniksaf dillqneqty pliydtkfng 841 lvssgdwgst stqydfgnty yndhhfhygy iihaaavigy vdsklngtwa adnkdwvnsl 901 vrdvanpsek deyfaqsrmf dwfnghswaa glyengngkn eesssedynf ayamklwgat 961 igdqsmelrg dlmisimkda mndyfyyqnd ntvepeeiig nkvsgilfdn iidyttyfgt 1021 nteyihgihm lpitpvssni rsetfveeew qtkiepiies iesgwtgilk lnqalfdpvd 1081 syaffsdstf dsstyldngm srtwalafsg glansia // LOCUS NP_014466 272 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNR068C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014466 VERSION NP_014466.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183245.1 REFERENCE 1 (residues 1 to 272) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 272) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 272) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 272) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10609. Method: conceptual translation. FEATURES Location/Qualifiers source 1..272 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..272 /product="uncharacterized protein" /calculated_mol_wt="31088" Region 5..270 /region_name="Bul1_C" /note="Bul1 C terminus; pfam04426" /db_xref="CDD:367936" CDS 1..272 /locus_tag="YNR068C" /gene_synonym="BUL3" /coded_by="NM_001183245.1:1..819" /note="hypothetical protein; exhibits homology to C-terminal end of Bul1p; expressed as a readthrough product of BSC5, the readthrough locus being termed BUL3; the BUL3 readthrough product is involved in ubiquitin-mediated sorting of plasma membrane proteins and interacts with WW domains of Rsp5p in vitro, but in a functionally different way than the non-readthrough form" /db_xref="GeneID:855805" /db_xref="SGD:S000005351" ORIGIN 1 mrnrqnqknw tnlrgllsve ereklenlrl elvcmqaans iphdppeiss letelicltt 61 ntkdckpvrf hsdlllkkhk yneikkifke ilenieayrd eftknqtkin llladdaras 121 lrnrsldfsd lmpssiikdv qvlanmeanv vvmknalktk lvgeksvpva sspissiipr 181 tsrnkktsps nyhhsvlshr ksnewnqvss teykrtllln ikynddfkat ivpsfesclc 241 srsyflrvkl hfdkgvgsae idipvqvkns fi // LOCUS NP_014467 489 aa linear PLN 30-JUN-2025 DEFINITION Bsc5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014467 VERSION NP_014467.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183246.3 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10610. On Jul 30, 2012 this sequence version replaced NP_014467.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..489 /product="Bsc5p" /calculated_mol_wt="54701" Region 58..462 /region_name="ART10-like" /note="Arrestin-related trafficking adapter 10 and similar proteins; cl04511" /db_xref="CDD:446410" CDS 1..489 /gene="BSC5" /locus_tag="YNR069C" /gene_synonym="BUL3" /coded_by="NM_001183246.3:1..1470" /note="hypothetical protein; shows homology with N-terminal end of Bul1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough expression includes YNR068C and the locus for this readthrough is termed BUL3; Bul3p is involved in ubiquitin-mediated sorting of plasma membrane proteins; readthrough and shortened forms of Bul3p interact with Rsp5p differently in vitro" /db_xref="GeneID:855806" /db_xref="SGD:S000005352" ORIGIN 1 mqeskepqnk fegcqrisss sstlfggtsf eeprcgtsqg keedafacnn gdhcssitnv 61 qeddfvlpel lpsfemyenl lsnipqssfd tyfpenppfy evasrnqsip segesgndmr 121 iltgdivgpd nhevtvdgrr fasgpaesqi rnyddtkgip veniyalpri ktpiatelyv 181 tktapkfgql pkhesmlrey tsgdiihgyf tvenkstkpi kfdmfyltle gttssktqsp 241 fgiqktteri lrmvdmaasw synhedvntg edlcgffdsi dktsfglpns rilnpgdkrk 301 kfftfkipnq lldvtckhgh fshsllpptl gfdrpssshp elstlkfses lgygrlserg 361 sslwlndsss gslinysina mivgkdvasg rvclmsekky sirivpfgfq nnpisrekcl 421 kdledfdiei anrlgmiekv fskieraipi hkediqeanr sdqlsplrgk yewnavagnt 481 engtlkkkh // LOCUS NP_014468 1333 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette multidrug transporter PDR18 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014468 VERSION NP_014468.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183247.4 REFERENCE 1 (residues 1 to 1333) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1333) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 1333) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1333) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10611. On Jul 30, 2012 this sequence version replaced NP_014468.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1333 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..1333 /product="ATP-binding cassette multidrug transporter PDR18" /calculated_mol_wt="149620" Region 1..1333 /region_name="3a01205" /note="Pleiotropic Drug Resistance (PDR) Family protein; TIGR00956" /db_xref="CDD:273362" CDS 1..1333 /gene="PDR18" /locus_tag="YNR070W" /coded_by="NM_001183247.4:1..4002" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21831043]" /experiment="EXISTENCE:mutant phenotype:GO:0008559 ABC-type xenobiotic transporter activity [PMID:21831043]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:21831043]" /experiment="EXISTENCE:mutant phenotype:GO:0055092 sterol homeostasis [PMID:21831043]" /experiment="EXISTENCE:mutant phenotype:GO:0071466 cellular response to xenobiotic stimulus [PMID:21831043]" /note="Transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:855807" /db_xref="SGD:S000005353" ORIGIN 1 mecvsvegld ssflegqtfg dilclpwtii kgirerknrn kmkiilknvs llaksgemvl 61 vlgrpgagct sflksaaget sqfaggvttg hisydgipqk emmqhykpdv iyngeqdvhf 121 phltvkqtld faisckmpak rvnnvtkeey itanrefyak ifglthtfdt kvgndfisgv 181 sggerkrvsi aealaakgsi ycwdnatrgl dsstalefar airtmtnllg ttalvtvyqa 241 seniyetfdk vtvlyagrqi fcgktteakd yfenmgylcp prqstaeylt aitdpnglhe 301 ikpgfeyqvp htadefekyw ldspeyarlk geiqkykhev ntewtkktyn esmaqekskg 361 trkksyytvs yweqirlcti rgflriygdk sytvintcaa iaqafitgsl fyqapsstlg 421 afsrsgvlff sllyyslmgl anisfehrpi lqkhkvysly hpsaealast issfpfrmig 481 ltffiiilyf laglhrsaga fftmyllltm cseaitslfq mvsslcdtls qansiagvvm 541 lsiamystym iqlpsmhpwf kwisyilpir yafesmlnae fhgrhmdcgg tlvpsgpgfe 601 nilpenqvca fvgsrpgqsw vlgddylraq yqyeykntwr nfgimwcfli gyivlravft 661 eykspvksgg dalvvkkgtk naiqrswssk ndeenlnasi atqdmkeias snddstsadf 721 eglestgvfi wknvsftiph ssgqrkllds vsgycvpgtl taligesgag kttllntlaq 781 rnvgtitgdm lvdglpmdas fkrrtgyvqq qdlhvaeltv keslqfsarm rrpqsipdae 841 kmeyvekiis ilemqefsea lvgeigygln veqrkklsig velvgkpdll lfldeptsgl 901 dsqsawavvk mlkrlalagq silctihqps atlfeqfdrl lllgkggqti yfgeigknss 961 svikyfekng arkcqqnenp aeyileaiga gatasvqqnw pdiwqkshey aninekindm 1021 ikdlssttlh ktatraskya tsysyqfhhv lkrssltfwr nlnyimakmm llmisglfig 1081 ftffhvgvna iglqnslfac fmaivisapa tnqiqeratv akelyevres ksnmfhwsll 1141 lithylnelp yhllfstiff vssyfplgvf teasrssvfy lnyailfqly yiglalmily 1201 mspnlqsanv ivgfilsfll sfcgavqpas lmpgfwtfmw klspytyflq nlvgllmhdk 1261 pvrcskkels lfnppvgqtc geftkpffef gtgyianpda tadcaycqyk vgdeylarin 1321 asfsylwrnf gfi // LOCUS NP_014469 342 aa linear PLN 30-JUN-2025 DEFINITION aldose 1-epimerase superfamily protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_014469 VERSION NP_014469.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183248.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10612. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..342 /product="aldose 1-epimerase superfamily protein" /calculated_mol_wt="37721" Region 13..340 /region_name="galactose_mutarotase_like" /note="galactose mutarotase_like; cd09019" /db_xref="CDD:185696" Site order(58,69,94,176,178,240,289,307) /site_type="active" /db_xref="CDD:185696" Site order(176,307) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:185696" CDS 1..342 /locus_tag="YNR071C" /coded_by="NM_001183248.1:1..1029" /note="Putative aldose 1-epimerase" /db_xref="GeneID:855808" /db_xref="SGD:S000005354" ORIGIN 1 msnsngdnky gvitigdekk fqatiaplga tlvdlkvngq svvqgysnvq dyltdgnmmg 61 atvgryanri akgvfslddg phkltvnncg ntnhssissl nlkqykaspv enpskgvyvv 121 efkllddhtq pnpnefpgdl evtvkytlnv aemtldmeyq aqlvrgdatp inmtnhsyfn 181 lnkvkseksi rgtevkvcsn kslevtegal lptgkiiern iatfdstkpt vlhedtpvfd 241 ctfiidankd lkttdsvsvn klvpvfkayh peshikfevs tteptvhlyt gdnlcgkfvp 301 rsgfavqqgr yvdainrdew rgcvllkrge vytsktqykf di // LOCUS NP_014470 564 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014470 VERSION NP_014470.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183249.1 REFERENCE 1 (residues 1 to 564) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 564) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 564) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 564) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10613. Method: conceptual translation. FEATURES Location/Qualifiers source 1..564 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..564 /product="hexose transporter HXT17" /calculated_mol_wt="62697" Region 60..521 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(71,75,202,205..206,209,328..329,333..334,337..338, 363,433..434,437..438,442,465..466,469) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..564 /gene="HXT17" /locus_tag="YNR072W" /gene_synonym="HLT4" /coded_by="NM_001183249.1:1..1695" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015795 sorbitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:genetic interaction:GO:0015797 mannitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="Putative transmembrane polyol transporter; supports growth on and uptake of mannitol and sorbitol with moderate affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; induced by raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose; HXT17 has a paralog, HXT13, that arose from a segmental duplication" /db_xref="GeneID:855809" /db_xref="SGD:S000005355" ORIGIN 1 mqsstesdrd iqdgpdadih vappvekews dgfddnevin gdnveppkrg ligylviyll 61 cypisfggfl pgwdsgitag finmdnfkmn fgsykhstge yylsnvrmgl lvamfsigca 121 igglifarla dtlgrrlaiv ivvlvymvga iiqissnhkw yqyfvgkiiy glgaggcsvl 181 cpmllseiap tdlrgglvsl yqlnmtfgif lgycsvygtr kydntaqwrv plglcflwtl 241 iiiigmllvp espryliece rheearasia kinkvspedp wvlkqadein agvlaqrelg 301 easwkelfsv ktkvlqrlit gilvqtflql tgenyfffyg ttifksvglt dgfetsivlg 361 tvnffstiia vmvvdkigrr kcllfgaagm macmvifasi gvkclyphgq dgpsskgagn 421 amivftcfyi fcfattwapv ayivvaesfp skvksramsi stacnwlwqf ligfftpfit 481 gsihfyygyv fvgclvamfl yvffflpeti glsleeiqll yeegikpwks aswvppsrrg 541 ipseesktek kdwkkflkfs kgsd // LOCUS NP_014471 502 aa linear PLN 30-JUN-2025 DEFINITION putative mannitol dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014471 VERSION NP_014471.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183250.3 REFERENCE 1 (residues 1 to 502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 502) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10614. On Jul 30, 2012 this sequence version replaced NP_014471.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..502 /product="putative mannitol dehydrogenase" /EC_number="1.1.1.67" /calculated_mol_wt="56339" Region 12..500 /region_name="MtlD" /note="Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; COG0246" /db_xref="CDD:440016" CDS 1..502 /gene="MAN2" /locus_tag="YNR073C" /coded_by="NM_001183250.3:1..1509" /experiment="EXISTENCE:mutant phenotype:GO:0046029 mannitol dehydrogenase activity [PMID:26996892]" /note="Mannitol dehydrogenase; MAN2 has a paralog, DSF1, that arose from a segmental duplication" /db_xref="GeneID:855810" /db_xref="SGD:S000005356" ORIGIN 1 mtksdettat slnaktlksf estlpiptyp regvkqgivh lgvgafhrsh lavfmhrlmq 61 ehhlkdwsic gvglmkadal mrdamkaqdc lytlvergik dtnayivgsi taymyapddp 121 raviekmanp dthivsltvt engyyhseat nslmtdapei indlnhpekp dtlygylyea 181 lllrykrglt pftimscdnm pqngvtvktm lvafaklkkd ekfaawiedk vtspnsmvdr 241 vtprctdker kyvadtwgik dqcpvvaepf iqwvlednfs dgrppwelvg vqvvkdvdsy 301 elmklrllng ghsamgylgy lagytyihev vndptinkyi rvlmreevip llpkvpgvdf 361 eeytasvler fsnpaiqdtv ariclmgsgk mpkyvlpsiy eqlrkpdgky kllavcvagw 421 fryltgvdmn gkpfeiedpm aptlkaaavk ggkdphelln ievlfspeir dnkefvaqlt 481 hsletvydkg piaaikeild qv // LOCUS NP_014472 378 aa linear PLN 30-JUN-2025 DEFINITION Aif1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014472 VERSION NP_014472.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183251.1 REFERENCE 1 (residues 1 to 378) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 378) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 378) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 378) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10615. Method: conceptual translation. FEATURES Location/Qualifiers source 1..378 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..378 /product="Aif1p" /calculated_mol_wt="41204" Region 5..363 /region_name="Ndh" /note="NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; COG1252" /db_xref="CDD:440864" CDS 1..378 /gene="AIF1" /locus_tag="YNR074C" /gene_synonym="CPD1" /coded_by="NM_001183251.1:1..1137" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15381687]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15381687]" /experiment="EXISTENCE:mutant phenotype:GO:0000304 response to singlet oxygen [PMID:11409174]" /experiment="EXISTENCE:mutant phenotype:GO:0043065 positive regulation of apoptotic process [PMID:15381687]" /note="Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli; triggers apoptosis in cells lacking HXK2; homolog of mammalian Apoptosis-Inducing Factor, putative reductase" /db_xref="GeneID:855811" /db_xref="SGD:S000005357" ORIGIN 1 mtintknivv vgagvfgvsv anhlyrelgg tyaiklvtas nyvyflpsav rltvskdytk 61 silplknvld sgievikdta asfddkevvl gsdraikfdi lvlatgskwa dpigstytfg 121 dnykeyfere asrisdadhi lflgggfvnc elagellfky leeirsgkkr isiihnsdkl 181 lpdsglyndt lrknvtdyls kngitlylnt vgasldtspk riflgegssk yidadliyrg 241 vgispnvpvn sisdlcdkkg fiqveknfrv kaveagnvfa igdvtnfryh glvkrdnwvd 301 vltrnvissl qegteaslvd adcletghap sgvslgpnag fgqfplpllg tinipsflis 361 raksknlfsd kmeplfkk // LOCUS NP_014473 374 aa linear PLN 30-JUN-2025 DEFINITION Cos10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014473 VERSION NP_014473.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183252.1 REFERENCE 1 (residues 1 to 374) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 374) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 374) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 374) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10616. Method: conceptual translation. FEATURES Location/Qualifiers source 1..374 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..374 /product="Cos10p" /calculated_mol_wt="43736" Region 66..160 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" Region 262..346 /region_name="DUP" /note="DUP family; pfam00674" /db_xref="CDD:395546" CDS 1..374 /gene="COS10" /locus_tag="YNR075W" /coded_by="NM_001183252.1:1..1125" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:11378903]" /note="Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins" /db_xref="GeneID:855812" /db_xref="SGD:S000005358" ORIGIN 1 mgeeirllss kglethssfc lpedifrnrl twlcseirns gfwiwslswl plavwwgmas 61 twfyplltsv vlilaliail pvvqiqysky tlsnqltqls keiiksapga ysadwdavai 121 hfnsylyenk awktahfffn gtdcqeafrk tilepavlrr qnedprfssi eilvpyteda 181 vqvyftkvna qwrlihgkke ckltmlenvk lpketyrckl awscqriris fspldflpdm 241 sdfficanls paclvsywli diffrmiddf qnirpksmkv ddkmqylsdi ineqgaspek 301 wdtiarktnt rlfekrvwkn eefffdgtdc qaffernfss llfskksasp rslnvelwky 361 iqeaqlscny eplp // LOCUS NP_878159 30 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNR075C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878159 VERSION NP_878159.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184621.3 REFERENCE 1 (residues 1 to 30) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 30) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 30) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 30) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 30) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 30) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 30) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 30) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10617. On Jul 30, 2012 this sequence version replaced NP_878159.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..30 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..30 /product="uncharacterized protein" /calculated_mol_wt="3236" CDS 1..30 /locus_tag="YNR075C-A" /coded_by="NM_001184621.3:1..93" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466517" /db_xref="SGD:S000028706" ORIGIN 1 mpiigvprcl enpfcapakf plsvkkkiri // LOCUS NP_014474 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014474 VERSION NP_014474.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183253.3 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10618. On Jul 30, 2012 this sequence version replaced NP_014474.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..120 /product="seripauperin PAU6" /calculated_mol_wt="12774" Region 26..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU6" /locus_tag="YNR076W" /coded_by="NM_001183253.3:1..363" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Member of the seripauperin multigene family; encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; active during alcoholic fermentation; regulated by anaerobiosis; negatively regulated by oxygen; repressed by heme; identical to Pau18p" /db_xref="GeneID:855813" /db_xref="SGD:S000005359" ORIGIN 1 mvkltsiaag vaaiaatasa tttlaqsder vnlvelgvyv sdirahlaqy ymfqaahpte 61 typvevaeav fnygdfttml tgiapdqvtr mitgvpwyst rlkpaiskal skdgiytian // LOCUS NP_001254791 84 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YNR077C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001254791 VERSION NP_001254791.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001267862.1 REFERENCE 1 (residues 1 to 84) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 84) AUTHORS Philippsen,P., Kleine,K., Pohlmann,R., Dusterhoft,A., Hamberg,K., Hegemann,J.H., Obermaier,B., Urrestarazu,L.A., Aert,R., Albermann,K., Altmann,R., Andre,B., Baladron,V., Ballesta,J.P., Becam,A.M., Beinhauer,J., Boskovic,J., Buitrago,M.J., Bussereau,F., Coster,F., Crouzet,M., D'Angelo,M., Dal Pero,F., De Antoni,A., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications JOURNAL Nature 387 (6632 SUPPL), 93-98 (1997) PUBMED 9169873 REFERENCE 3 (residues 1 to 84) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 84) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (26-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 84) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35135. Method: conceptual translation. FEATURES Location/Qualifiers source 1..84 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XIV" Protein 1..84 /product="uncharacterized protein" /calculated_mol_wt="9609" Region 1..84 /region_name="DUF468" /note="Protein of unknown function (DUF468); pfam04318" /db_xref="CDD:367903" CDS 1..84 /locus_tag="YNR077C" /coded_by="NM_001267862.1:1..255" /note="hypothetical protein, abundance changes with carbon source" /db_xref="GeneID:855814" /db_xref="SGD:S000005360" ORIGIN 1 mhgtclsgly pepfthnshd yphfniyisf ggpkycital ntyvipllhh ilttqfihty 61 fniptksppk spkhknylsf nftk // LOCUS NP_878160 51 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL166W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878160 VERSION NP_878160.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184623.1 REFERENCE 1 (residues 1 to 51) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 51) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 51) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 51) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10619. Method: conceptual translation. FEATURES Location/Qualifiers source 1..51 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..51 /product="uncharacterized protein" /calculated_mol_wt="5821" Region 1..>45 /region_name="DUF468" /note="Protein of unknown function (DUF468); pfam04318" /db_xref="CDD:367903" CDS 1..51 /locus_tag="YOL166W-A" /coded_by="NM_001184623.1:1..156" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466472" /db_xref="SGD:S000028709" ORIGIN 1 mhgaclsgly plpfthkfhd ylhfniyisf ggpkycital ntyvilfytv y // LOCUS NP_014477 143 aa linear PLN 30-JUN-2025 DEFINITION putative aryl-alcohol dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014477 VERSION NP_014477.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183418.1 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10620. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..143 /product="putative aryl-alcohol dehydrogenase" /calculated_mol_wt="15591" Region <1..115 /region_name="AKR_SF" /note="Aldo-keto reductase (AKR) superfamily; cl00470" /db_xref="CDD:444925" CDS 1..143 /gene="AAD15" /locus_tag="YOL165C" /coded_by="NM_001183418.1:1..432" /note="Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role; AAD15 has a paralog, AAD3, that arose from a segmental duplication; members of the AAD gene family comprise three pairs (AAD3 + AAD15, AAD6/AAD16 + AAD4, AAD10 + AAD14) whose two genes are more related to one another than to other members of the family" /db_xref="GeneID:853999" /db_xref="SGD:S000005525" ORIGIN 1 marhfgmala pwdvmgggrf qskkameerr kngecirsfv gaseqtdaei kisealakva 61 eehgtesvta iaiayvrska knvfpsvegg kiedlkenik alsidltpdn ikylenvvpf 121 digfpntfiv lnsltqkygt nnv // LOCUS NP_878161 60 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL164W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878161 VERSION NP_878161.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184575.1 REFERENCE 1 (residues 1 to 60) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 60) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 60) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 60) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 60) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10621. Method: conceptual translation. FEATURES Location/Qualifiers source 1..60 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..60 /product="uncharacterized protein" /calculated_mol_wt="6868" CDS 1..60 /locus_tag="YOL164W-A" /coded_by="NM_001184575.1:1..183" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466473" /db_xref="SGD:S000028580" ORIGIN 1 mfaklyrglt yvtnkilstl lshhsihyci nsfkpttlai iillhpccrc nvyiircihh // LOCUS NP_014478 646 aa linear PLN 30-JUN-2025 DEFINITION sulfuric ester hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014478 VERSION NP_014478.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183417.1 REFERENCE 1 (residues 1 to 646) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 646) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 646) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 646) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 646) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10622. Method: conceptual translation. FEATURES Location/Qualifiers source 1..646 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..646 /product="sulfuric ester hydrolase" /calculated_mol_wt="72515" Region 16..639 /region_name="BDS1" /note="Alkyl sulfatase BDS1 and related hydrolases, metallo-beta-lactamase superfamily [Secondary metabolites biosynthesis, transport and catabolism]; COG2015" /db_xref="CDD:441618" CDS 1..646 /gene="BDS1" /locus_tag="YOL164W" /coded_by="NM_001183417.1:1..1941" /experiment="EXISTENCE:mutant phenotype:GO:0018741 linear primary-alkylsulfatase activity [PMID:15947202]" /experiment="EXISTENCE:mutant phenotype:GO:0018909 dodecyl sulfate metabolic process [PMID:15947202]" /note="Bacterially-derived sulfatase; required for use of alkyl sulfates as sulfur source" /db_xref="GeneID:854000" /db_xref="SGD:S000005524" ORIGIN 1 migafkrnrg ssqsfakecq pstlkanlev akelpfsdrr dfedatqgyi gslsdeqiig 61 pdggvvwcmk sygflepetp antvnpslwr qaqlnaihgl fkitdnvyqv rgldisnmti 121 iegntsliii dtlfttetaq eslklyyrhr pqkpvrtviy thshsdhygg vkgivkeadv 181 ksgevqiiap vgfmesvvae nilagnamhr rsqyqfgmll spsvkghvdc gigkaashgt 241 vtliaptiii eepveertid gvdfvfqlap gseapsemli ympqqrvlnm aedvthhmhn 301 lyalrgvevr dgnqwakyid aarvafgskt dvliaqhhwp ttgqmrinel lkkqrdmykf 361 ihdqtlrlln qgytsrdiae tlrmpssleq ewstrgyygt lshnvkavyq kylgwydanp 421 anlnplppva yakkaveymg gadavlaray kdfqkgefrw vasvvnqlvf adpnnhqare 481 lcadaleqlg yqaeastwrn aylvgamelr qgvpkrrstg krnniavlnn emffdflavr 541 lnatkaegki ivsnwcfins nerfvitlen caltyiqgwq tdadatitlk rttfeallan 601 eitmvdflrs keveiegnrl rieellklfd dfdqsfpvve pmggst // LOCUS NP_014479 169 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL163W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014479 VERSION NP_014479.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183416.1 REFERENCE 1 (residues 1 to 169) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 169) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 169) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 169) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10623. Method: conceptual translation. FEATURES Location/Qualifiers source 1..169 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..169 /product="uncharacterized protein" /calculated_mol_wt="19331" Region 1..>151 /region_name="MFS" /note="Major Facilitator Superfamily; cl28910" /db_xref="CDD:475125" CDS 1..169 /locus_tag="YOL163W" /coded_by="NM_001183416.1:1..510" /note="hypothetical protein; proposed to be an inactive evolutionary remnant that along with neighboring gene YOL162W may have constituted a second sulfonate transporter and SOA1 paralog that is intact in S. uvarum, S. eubayanus and S. arboricola and named SOA2; member of the Dal5p subfamily of the major facilitator family" /db_xref="GeneID:854001" /db_xref="SGD:S000005523" ORIGIN 1 miawslvatl qckmtgkssf ytcralmglf eggfvadlvl wmsyfyssse lsirlsffwv 61 tlsltqiits ivafgvfhmr giggmagwqw lflieriftl vigisayflm vpsvvqtkkp 121 wskkgwfter eekiivnkil rddptkgdmn nrqgmslkml wqgitdyyi // LOCUS NP_014480 215 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL162W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014480 VERSION NP_014480.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183415.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10624. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..215 /product="uncharacterized protein" /calculated_mol_wt="24352" Region <1..169 /region_name="MFS" /note="Major Facilitator Superfamily; cl28910" /db_xref="CDD:475125" CDS 1..215 /locus_tag="YOL162W" /coded_by="NM_001183415.1:1..648" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; proposed to be an inactive evolutionary remnant that along with neighboring gene YOL163W may have constituted a second sulfonate transporter and SOA1 paralog that is intact in S. uvarum, S. eubayanus and S. arboricola and named SOA2; member of the Dal5p subfamily of the major facilitator family" /db_xref="GeneID:854002" /db_xref="SGD:S000005522" ORIGIN 1 mgllayiptn vlatyltlvl rsigfttfqa nllaipnfvl hilllfgltw stekcnnrlg 61 lsllqplytv pllavlrfwk gtmfnkwgty aiitlildnp yihaicvslc srnsqsvktr 121 tvstclynmf vqagliissn iyaksdaply rkgngvlfgl alfmfpilig skliyvyink 181 qrdkrwnams eeekdhylst tsdagsrrld frfyh // LOCUS NP_014481 120 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014481 VERSION NP_014481.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183414.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10625. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..120 /product="seripauperin PAU20" /calculated_mol_wt="12746" Region 23..115 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..120 /gene="PAU20" /locus_tag="YOL161C" /coded_by="NM_001183414.1:1..363" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP and mCherry fusion proteins localize to the vacuole; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation" /db_xref="GeneID:854003" /db_xref="SGD:S000005521" ORIGIN 1 mvkltsiaag vaaiaagasa tttlaqsder vnlvelgvyv sdirahlaqy ymfqaahpte 61 typvevaeav fnygdfttml tgispdqvtr mitgvpwyst rlkpaiskal skdgiytian // LOCUS NP_001335811 113 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL160W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335811 VERSION NP_001335811.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348873.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80331. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..113 /product="uncharacterized protein" /calculated_mol_wt="13366" CDS 1..113 /locus_tag="YOL160W" /coded_by="NM_001348873.1:1..342" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:854004" /db_xref="SGD:S000005520" ORIGIN 1 meniaficlq sctrgiygcq fysatlenyh nisfpifllq ttlfnhcisl nwskavfnri 61 krrkymmelk khcynyqvsr ignrkkngcf flkmannrvf svknsprlll ffi // LOCUS NP_076909 90 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL159C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_076909 VERSION NP_076909.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184493.1 REFERENCE 1 (residues 1 to 90) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 90) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 90) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 90) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10626. Method: conceptual translation. FEATURES Location/Qualifiers source 1..90 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..90 /product="uncharacterized protein" /calculated_mol_wt="10802" CDS 1..90 /locus_tag="YOL159C-A" /coded_by="NM_001184493.1:1..273" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21777356]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:21777356]" /note="hypothetical protein; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species" /db_xref="GeneID:854005" /db_xref="SGD:S000007627" ORIGIN 1 mqyceldlsg qwldtvycee nfsdfvfikf lnpsqfeeki ycytlhitkr tlenkrllly 61 yedefkkhgh dinelvgdgi ilrscwnprq // LOCUS NP_014483 171 aa linear PLN 30-JUN-2025 DEFINITION Css3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014483 VERSION NP_014483.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183412.1 REFERENCE 1 (residues 1 to 171) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 171) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 171) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 171) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 171) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10627. Method: conceptual translation. FEATURES Location/Qualifiers source 1..171 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..171 /product="Css3p" /calculated_mol_wt="19443" CDS 1..171 /gene="CSS3" /locus_tag="YOL159C" /coded_by="NM_001183412.1:1..516" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein, secreted when constitutively expressed; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cell periphery, SWAT-GFP fusion also localizes to the extracellular region, and mCherry fusion also localizes to the vacuole; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA" /db_xref="GeneID:854006" /db_xref="SGD:S000005519" ORIGIN 1 mvplfglfci fsqlyslcsa yvditsgyqv ffnlptnmtn nqicwlfqas yydiysdksg 61 rtlrtgrfep gdqqsliyrd tlveleaitd syeysnldls tyngpepyns etdyctdimd 121 lvmrvydeeg hyvhpvanns tnacahptpp tlnnllisny sdgrnykess i // LOCUS NP_014484 606 aa linear PLN 30-JUN-2025 DEFINITION Enb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014484 VERSION NP_014484.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183411.1 REFERENCE 1 (residues 1 to 606) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 606) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 606) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 606) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10628. Method: conceptual translation. FEATURES Location/Qualifiers source 1..606 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..606 /product="Enb1p" /calculated_mol_wt="66839" Region 63..574 /region_name="MFS_ARN_like" /note="Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; cd17322" /db_xref="CDD:340880" Site order(77..78,81..82,85,116,166..167,169..171,174,190, 193..194,197,356,359..360,363..365,368,396,400,454..455, 459,463,479,482..483,486..487,490) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340880" CDS 1..606 /gene="ENB1" /locus_tag="YOL158C" /gene_synonym="ARN4" /coded_by="NM_001183411.1:1..1821" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17714436]" /experiment="EXISTENCE:direct assay:GO:0033101 cellular bud membrane [PMID:17714436]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015620 ferric-enterobactin transmembrane transporter activity [PMID:10831226]" /experiment="EXISTENCE:mutant phenotype:GO:0015685 ferric-enterobactin import into cell [PMID:10831226]" /note="Ferric enterobactin transmembrane transporter; expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment" /db_xref="GeneID:854007" /db_xref="SGD:S000005518" ORIGIN 1 mletdhsrnd nlddkstvcy sektdsnvek sttsglrrid avnkvlsdys sftafgvtfs 61 slktallval flqgyctglg gqisqsiqty aansfgkhsq vgsintvksi vasvvavpya 121 risdrfgrie cwifalvlyt igeiisaatp tfsglfagiv iqqfgysgfr llataltgdl 181 sglrdrtfam niflipviin twvsgnivss vagnvapykw rwgygifcii vpistlilvl 241 pyvyaqyisw rsgklpplkl kekgqtlrqt lwkfaddinl igvilftafl vlvllpltia 301 ggatskwreg hiiamivvgg clgfifliwe lkfaknpfip rvylgdptiy vallmefvwr 361 lglqieleyl vtvlmvafge stlsaqriaq lynflqsctn ivvgimlhfy phpkvfvvag 421 sllgvigmgl lykyrvvydg isgligaeiv vgiaggmirf pmwtlvhast thnematvtg 481 llmsvyqigd avgasiagai wtqrlakeli qrlgsslgma iyksplnylk kypigsevrv 541 qmiesyskiq rlliivsisf aafnavlcff lrgftvnkkq slsaeereke klkikqqswl 601 rrvigy // LOCUS NP_014485 589 aa linear PLN 30-JUN-2025 DEFINITION oligo-1,6-glucosidase IMA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014485 VERSION NP_014485.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183410.1 REFERENCE 1 (residues 1 to 589) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 589) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 589) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 589) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10629. Method: conceptual translation. FEATURES Location/Qualifiers source 1..589 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..589 /product="oligo-1,6-glucosidase IMA2" /EC_number="3.2.1.10" /calculated_mol_wt="68494" Region 16..503 /region_name="AmyAc_SI_OligoGlu_DGase" /note="Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; cd11333" /db_xref="CDD:200472" Site order(30,32,34,38) /site_type="other" /note="Ca binding site [ion binding]" /db_xref="CDD:200472" Site order(69,72,109,112,159,178,182,215,277,442) /site_type="active" /db_xref="CDD:200472" Site order(215,277,352) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:200472" Region 514..585 /region_name="Malt_amylase_C" /note="Maltogenic Amylase, C-terminal domain; pfam16657" /db_xref="CDD:435493" CDS 1..589 /gene="IMA2" /locus_tag="YOL157C" /coded_by="NM_001183410.1:1..1770" /experiment="EXISTENCE:direct assay:GO:0004574 oligo-1,6-glucosidase activity [PMID:20471265]" /experiment="EXISTENCE:direct assay:GO:0004575 sucrose alpha-glucosidase activity [PMID:24649402]" /experiment="EXISTENCE:genetic interaction:GO:0046352 disaccharide catabolic process [PMID:20562106|PMID:20471265]" /experiment="EXISTENCE:mutant phenotype:GO:0004574 oligo-1,6-glucosidase activity [PMID:20562106]" /note="Isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase); preferred specificity for isomaltose, alpha-methylglucoside, and palatinose, but also exhibits alpha-1,2 glucosidase activity on sucrose and kojibiose, and can cleave the 1,3-alpha linkage of nigerose and turanose and the alpha-1,5 linkage of leucrose in vitro; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose" /db_xref="GeneID:854008" /db_xref="SGD:S000005517" ORIGIN 1 mtissahpet epkwwkeati yqiypasfkd snndgwgdmk giaskleyik elgadaiwis 61 pfydspqddm gydianyekv wptygtnedc faliekthkl gmkfitdlvi nhcssehewf 121 kesrssktnp krdwffwrpp kgydaegkpi ppnnwrsyfg gsawtfdekt qefylrlfcs 181 tqpdlnwene dcrkaiyesa vgywldhgvd gfridvgsly skvaglpdap videnskwqp 241 sdpftmngpr ihefhqemnk firnrvkdgr eimtvgemqh atdetkrlyt sasrhelsel 301 fnfshtdvgt spkfrqnlip yelkdwkval aelfryvngt dcwstiylen hdqprsitrf 361 gddspknrvi sgkllsvllv slsgtlyvyq gqelgeinfk nwpiekyedv evrnnydaik 421 eehgenskem krfleaiali srdhartpmq wsreepnagf sgpnakpwfy lnesfregin 481 aedeskdpns vlnfwkealr frkahkditv ygydfefidl dnkklfsftk kydnktlfaa 541 lnfssdsidf tipnnsssfk lefgnyprse vdassrtlkp wegriyise // LOCUS NP_014486 567 aa linear PLN 30-JUN-2025 DEFINITION hexose transporter HXT11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014486 VERSION NP_014486.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183409.1 REFERENCE 1 (residues 1 to 567) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 567) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 567) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 567) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10630. Method: conceptual translation. FEATURES Location/Qualifiers source 1..567 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..567 /product="hexose transporter HXT11" /calculated_mol_wt="62602" Region 64..526 /region_name="Sugar_tr" /note="Sugar (and other) transporter; pfam00083" /db_xref="CDD:395036" Site order(75,79,205,208..209,212,331..332,336..337,340..341, 366,438..439,442..443,447,470..471,474) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340914" CDS 1..567 /gene="HXT11" /locus_tag="YOL156W" /gene_synonym="LGT3" /coded_by="NM_001183409.1:1..1704" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:1902341 xylitol transmembrane transport [PMID:26996892]" /experiment="EXISTENCE:mutant phenotype:GO:0005353 fructose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0005354 galactose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0008645 hexose transmembrane transport [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0015578 mannose transmembrane transporter activity [PMID:10618490]" /experiment="EXISTENCE:mutant phenotype:GO:0055056 D-glucose transmembrane transporter activity [PMID:10618490]" /note="Hexose transporter; capable of transporting a broad range of substrates including: glucose, fructose, mannose and galactose; polyol transporter that supports the growth on and uptake of xylitol with low affinity when overexpressed in a strain deleted for hexose family members; nearly identical in sequence to Hxt9p; has similarity to major facilitator superfamily (MFS) transporters; involved in pleiotropic drug resistance" /db_xref="GeneID:854009" /db_xref="SGD:S000005516" ORIGIN 1 msgvnntsan elsttmsnsn savgapsvkt ehgdsknsln ldaneppidl pqkplsaytt 61 vailclmiaf ggfifgwdtg tisgfvnlsd firrfgqknd kgtyylskvr mglivsifni 121 gcaiggivls kvgdiygrri glitvtaiyv vgiliqitsi nkwyqyfigr iisglgvggi 181 avlspmlise vapkhirgtl vqlyqlmgtm giflgyctny gtknyhnatq wrvglglcfa 241 watfmvsgmm fvpespryli evgkdeeakr slsksnkvsv ddpallveyd tikagielek 301 lagnaswsel lstktkvfqr vlmgvmiqsl qqltgdnyff yygttifksv glkdsfqtsi 361 iigvvnffss fiavytierf grrtcllwga asmlccfavf asvgvtklwp qgsshqdits 421 qgagncmivf tmffifsfat twaggcyviv setfplrvks rgmaiataan wmwgflisff 481 tpfitgainf yygyvflgcl vfayfyvfff vpetkgltle evntmwlegv pawksaswvp 541 perrtadyda daidhdnrpi ykrffss // LOCUS NP_878162 44 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL155W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878162 VERSION NP_878162.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184666.1 REFERENCE 1 (residues 1 to 44) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 44) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 44) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 44) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 44) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10631. Method: conceptual translation. FEATURES Location/Qualifiers source 1..44 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..44 /product="uncharacterized protein" /calculated_mol_wt="5072" CDS 1..44 /locus_tag="YOL155W-A" /coded_by="NM_001184666.1:1..135" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466474" /db_xref="SGD:S000028855" ORIGIN 1 mfygsfnkcv tgyscrmaih yyvyriiksa trpdyksntq ilvl // LOCUS NP_014487 967 aa linear PLN 30-JUN-2025 DEFINITION mannoprotein [Saccharomyces cerevisiae S288C]. ACCESSION NP_014487 VERSION NP_014487.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183408.1 REFERENCE 1 (residues 1 to 967) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 967) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 967) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 967) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 967) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 967) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 967) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 967) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 967) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10632. Method: conceptual translation. FEATURES Location/Qualifiers source 1..967 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..967 /product="mannoprotein" /calculated_mol_wt="94575" Region 337..617 /region_name="Hyphal_reg_CWP" /note="Hyphally regulated cell wall protein N-terminal; pfam11765" /db_xref="CDD:403079" Region 610..>817 /region_name="Chi1" /note="Chitinase [Carbohydrate transport and metabolism]; COG3469" /db_xref="CDD:442692" CDS 1..967 /gene="HPF1" /locus_tag="YOL155C" /coded_by="NM_001183408.1:1..2904" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11748726]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:11748726]" /note="Haze-protective mannoprotein; reduces particle size of aggregated proteins in white wines, thereby decreasing turbidity; intragenic repeat expansion controls chronological aging; expansion of intragenic tandem repeats within N-terminus sufficient to cause pronounced life span shortening; repeat expansion shifts cells from sedentary to buoyant, thereby increasing exposure to oxygen, altering methionine, lipid, and purine metabolism" /db_xref="GeneID:854010" /db_xref="SGD:S000005515" ORIGIN 1 mfnrfnklqa alalvlysqs algqyytnss siasnsstav sstssgsvsi sssieltsst 61 sdvsssltel tssstevsss iapstsssev sssitssgss vsgsssitss gssvsssssa 121 tesgssasgs ssatesgssv sgsstsitsg sssatesgss vsgstsates gssasgsssa 181 tesgssasgs ssatesgssv sgsssatesg ssvsgsssat esgsassvps ssgsvtesgs 241 sssasessit qsgtasgssa sstsgsvtqs gssvsgssas sapgisssip qstssastas 301 gsitsgtlss itssassata tasnslsssd gtiylpstti sgditltgsv iateavevaa 361 ggkltlldgd kyvfsadfii hggvfveksk ptypgtefdi sgenfdvsgt fnaeepaass 421 asaysftpgs fdnsgdisls lsestkgevt fspysnsgaf sfsnailngg svsglqrrae 481 sgsvnngein lengstyvvv epvsgsgtin iisgnlylhy pdtftgqtvv fkgegvlavd 541 ptetnttpip vvgytgenqi aitadvtals ydsatgvlta tqgnsqfsfs igtgfsssgf 601 nvsegtfaga yayylnyggv vassatpsst sttsgatnst sgstsfgasv tgstastsfg 661 asvtgstast lisgspsvyt ttltyattts tvvvscsett dsngnvytit ttvpcsstta 721 titscdetgc hvttstgtva tetvssksyt tvtvthcdnn gcntktvtse cpeetsattt 781 spksyttvtv thcddngcnt ktvtseapea ttttvspkty ttatvtqcdd ngcstktvts 841 eapketsets etsaapktyt tatvtqcddn gcnvkiitsq ipeatstvta tsaspksytt 901 vtsegskats lttaiskass aistysksaa piktstgiiv qsegiaagln antlnalvgi 961 fvlaffn // LOCUS NP_014488 249 aa linear PLN 30-JUN-2025 DEFINITION Zps1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014488 VERSION NP_014488.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183407.1 REFERENCE 1 (residues 1 to 249) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 249) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 249) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 249) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 249) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10633. Method: conceptual translation. FEATURES Location/Qualifiers source 1..249 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..249 /product="Zps1p" /calculated_mol_wt="27436" Region 8..248 /region_name="HRXXH" /note="Putative peptidase family; pfam13933" /db_xref="CDD:404766" Site order(186..187,190,202) /site_type="other" /note="putative Zn binding site [ion binding]" /db_xref="CDD:199916" CDS 1..249 /gene="ZPS1" /locus_tag="YOL154W" /coded_by="NM_001183407.1:1..750" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH" /db_xref="GeneID:854011" /db_xref="SGD:S000005514" ORIGIN 1 mkfssgksii fatiaslals apvtydtnst aelqspssqe ilgwshatfp tiyqtcnetn 61 armlnaafkd taeitaygkd rllnygvddv yykrwfgngs iftvmgvfeq lmeaskgaml 121 mrcddidglc aanpnyyagh hrqsapaetv icdyfytskk plsticfegt ivdvgpkhya 181 gidmlhrylh vptmsmdgyv geyaetleev vdytqnnaty avrntdnyly yladvysasv 241 ipggclgnl // LOCUS NP_014489 620 aa linear PLN 30-JUN-2025 DEFINITION putative ferric-chelate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014489 VERSION NP_014489.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183406.1 REFERENCE 1 (residues 1 to 620) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 620) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 620) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 620) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 620) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10634. On Jan 9, 2006 this sequence version replaced NP_014489.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..620 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..620 /product="putative ferric-chelate reductase" /EC_number="1.16.1.9" /calculated_mol_wt="70775" Region 161..282 /region_name="Ferric_reduct" /note="Ferric reductase like transmembrane component; pfam01794" /db_xref="CDD:426438" Region 328..500 /region_name="NOX_Duox_like_FAD_NADP" /note="NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; cd06186" /db_xref="CDD:99783" Site order(355,369..372,386..388,392..395,433) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(369,371..372) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99783" Region 423..595 /region_name="NAD_binding_6" /note="Ferric reductase NAD binding domain; pfam08030" /db_xref="CDD:429792" Site 428..438 /site_type="other" /note="NAD pyrophosphate binding region [chemical binding]" /db_xref="CDD:99783" Site order(428,432..435,437) /site_type="other" /note="beta-alpha-beta stucture motif" /db_xref="CDD:99783" Site order(460..461,464) /site_type="other" /note="NADP ribose binding motif [chemical binding]" /db_xref="CDD:99783" CDS 1..620 /gene="FRE7" /locus_tag="YOL152W" /coded_by="NM_001183406.1:1..1863" /experiment="EXISTENCE:direct assay:GO:0000293 ferric-chelate reductase activity [PMID:17681937]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17553781]" /experiment="EXISTENCE:genetic interaction:GO:0000293 ferric-chelate reductase activity [PMID:17553781]" /experiment="EXISTENCE:genetic interaction:GO:0006826 iron ion transport [PMID:17553781]" /experiment="EXISTENCE:genetic interaction:GO:0015677 copper ion import [PMID:17553781]" /note="Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels" /db_xref="GeneID:854013" /db_xref="SGD:S000005512" ORIGIN 1 mieerdlvls ngihciadih selyarlkke sqaatpwvyq kqygkfvtyf vaviiflsli 61 kklafmyyds seeflpekkn spttpsvfla rimtklvafn ryicyrkfpt lifsylgipt 121 svgtflvvma ttlytllycf vphpfyrpca gfgspplsvr agimaislvp fvfslsgkin 181 vigwlvglsy ekiniyhqwa silclffswv hvipflrqar heggyermhq rwkasdmwrs 241 gvppilflnl lwlsslpiar rhfyeiflql hwilavgfyi slfyhvypel nshmylvati 301 vvwfaqlfyr lavkgylrpg rsfmastian vsivgegcve livkdvemay spgqhifvrt 361 idkgiisnhp fsifpsakyp ggikmliraq kgfskrlyes nddmkkilid gpyggierdi 421 rsftnvylic sgsgistclp flqkygpilh ktnlevitld wvvrhredis wirdemctls 481 nnlrqlfldg kivvriyvcs dstvpgiikt fpqtidtasd qsdlakrekd tefgqddtes 541 nstfdksnne ykglitiips kpdlnqvind yqigfrncfi csgsdslryt vgnsvaglqa 601 kvfsnknvee cylhsesfgy // LOCUS NP_014490 342 aa linear PLN 30-JUN-2025 DEFINITION methylglyoxal reductase (NADPH-dependent) GRE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014490 VERSION NP_014490.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183405.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10635. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..342 /product="methylglyoxal reductase (NADPH-dependent) GRE2" /EC_number="1.1.1.265" /EC_number="1.1.1.283" /calculated_mol_wt="38038" Region 3..318 /region_name="AR_SDR_e" /note="aldehyde reductase, extended (e) SDRs; cd05227" /db_xref="CDD:187538" Site order(7,9..12,32,58,81..85,125..127,165,169,196..199, 215..216) /site_type="other" /note="NADP binding site [chemical binding]" /db_xref="CDD:187538" Site order(85,87,127..129,132,165,196..198,219,231,238,308) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:187538" Site order(127,165,169) /site_type="active" /db_xref="CDD:187538" CDS 1..342 /gene="GRE2" /locus_tag="YOL151W" /coded_by="NM_001183405.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0043892 methylglyoxal reductase (NADPH) activity [PMID:12722185]" /experiment="EXISTENCE:genetic interaction:GO:0008204 ergosterol metabolic process [PMID:16598690]" /experiment="EXISTENCE:mutant phenotype:GO:0008204 ergosterol metabolic process [PMID:16598690]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:16999827]" /experiment="EXISTENCE:mutant phenotype:GO:0046568 3-methylbutanal reductase [NAD(P)H] activity [PMID:16999827]" /note="3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase" /db_xref="GeneID:854014" /db_xref="SGD:S000005511" ORIGIN 1 msvfvsgang fiaqhivdll lkedykvigs arsqekaenl teafgnnpkf smevvpdisk 61 ldafdhvfqk hgkdikivlh taspfcfdit dserdllipa vngvkgilhs ikkyaadsve 121 rvvltssyaa vfdmakendk sltfneeswn patwescqsd pvnaycgskk faekaawefl 181 eenrdsvkfe ltavnpvyvf gpqmfdkdvk khlntscelv nslmhlsped kipelfggyi 241 dvrdvakahl vafqkretig qrlivsearf tmqdvldiln edfpvlkgni pvgkpgsgat 301 hntlgatldn kkskkllgfk frnlketidd tasqilkfeg ri // LOCUS NP_014492 231 aa linear PLN 30-JUN-2025 DEFINITION Dcp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014492 VERSION NP_014492.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183403.1 REFERENCE 1 (residues 1 to 231) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 231) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 231) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 231) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 231) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10636. Method: conceptual translation. FEATURES Location/Qualifiers source 1..231 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..231 /product="Dcp1p" /calculated_mol_wt="26135" Region 18..222 /region_name="Dcp1" /note="mRNA decapping enzyme 1 (Dcp1); cd09804" /db_xref="CDD:197362" Site order(18..19,23,25..26,29..30,40,42,64,145..147,150,152) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:197362" CDS 1..231 /gene="DCP1" /locus_tag="YOL149W" /gene_synonym="MRT2" /coded_by="NM_001183403.1:1..696" /experiment="EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:11139489]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:12730603|PMID:23509072]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:11139489]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23706738]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23706738|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:16341225]" /experiment="EXISTENCE:direct assay:GO:0098562 cytoplasmic side of membrane [PMID:27146487]" /experiment="EXISTENCE:direct assay:GO:0098745 RNA decapping complex [PMID:12554866]" /experiment="EXISTENCE:mutant phenotype:GO:0000932 P-body [PMID:12730603]" /experiment="EXISTENCE:physical interaction:GO:0098745 RNA decapping complex [PMID:10508173]" /note="Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:854016" /db_xref="SGD:S000005509" ORIGIN 1 mtgaataaen satqlefyrk alnfnvigry dpkikqllfh tphaslykwd fkkdewnkle 61 yqgvlaiylr dvsqntnllp vspqevdifd sqngsnniqv nngsdnsnrn ssgngnsyks 121 ndsltyncgk tlsgkdiyny gliilnrinp dnfsmgivpn svvnkrkvfn aeedtlnple 181 cmgvevkdel viiknlkhev ygiwihtvsd rqniyeliky llenepkdsf a // LOCUS NP_014493 604 aa linear PLN 30-JUN-2025 DEFINITION Spt20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014493 VERSION NP_014493.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183402.1 REFERENCE 1 (residues 1 to 604) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 604) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 604) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 604) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10637. Method: conceptual translation. FEATURES Location/Qualifiers source 1..604 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..604 /product="Spt20p" /calculated_mol_wt="67666" Region 131..341 /region_name="Spt20" /note="Spt20 family; pfam12090" /db_xref="CDD:463459" CDS 1..604 /gene="SPT20" /locus_tag="YOL148C" /gene_synonym="ADA5" /coded_by="NM_001183402.1:1..1815" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9224714|PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:mutant phenotype:GO:0003712 transcription coregulator activity [PMID:8649430]" /experiment="EXISTENCE:mutant phenotype:GO:0036498 IRE1-mediated unfolded protein response [PMID:10652329]" /note="Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay" /db_xref="GeneID:854017" /db_xref="SGD:S000005508" ORIGIN 1 msansptgnd phvfgipvna tpsnmgspgs pvnvpppmnp avanvnhpvm rtnsnsnane 61 gtrtltreqi qqlqqrqrll lqqrlleqqr kqqalqnyea qfyqmlmtln krpkrlynfv 121 edadsilkky eqylhsfefh iyennykica pansrlqqqq kqpeltsdgl iltknnetlk 181 efleyvargr ipdaimevlr dcniqfyegn lilqvydhtn tvdvtpkenk pnlnssssps 241 nnnstqdnsk iqqpsepnsg vantgantan kkasfkrprv yrtllkpndl ttyydmmsya 301 dnarfsdsiy qqfeseiltl tkrnlslsvp lnpyehrdml eetafsephw dsekksfihe 361 hraestregt kgvvghieer defpqhssny eqlmlimner tttitnstfa vsltknamei 421 assssngvrg assstsnsas ntrnnslang nqvalaaaaa aaavgstmgn dnnqfsrlkf 481 ieqwrinkek rkqqalsani nptpfnaris mtapltpqqq llqrqqqale qqqnggamkn 541 ankrsgnnat snnnnnnnnl dkpkvkrprk nakksesgtp apkkkrmtkk kqsasstpss 601 ttms // LOCUS NP_014494 236 aa linear PLN 30-JUN-2025 DEFINITION Pex11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014494 VERSION NP_014494.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183401.1 REFERENCE 1 (residues 1 to 236) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 236) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 236) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 236) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10638. Method: conceptual translation. FEATURES Location/Qualifiers source 1..236 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..236 /product="Pex11p" /calculated_mol_wt="26744" Region 12..233 /region_name="PEX11" /note="Peroxisomal biogenesis factor 11 (PEX11); pfam05648" /db_xref="CDD:398979" CDS 1..236 /gene="PEX11" /locus_tag="YOL147C" /gene_synonym="PMP24; PMP27" /coded_by="NM_001183401.1:1..711" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:7860627|PMID:7721939]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:20028986]" /experiment="EXISTENCE:direct assay:GO:1990429 peroxisomal importomer complex [PMID:22375831]" /experiment="EXISTENCE:mutant phenotype:GO:0001579 medium-chain fatty acid transport [PMID:10931862]" /experiment="EXISTENCE:mutant phenotype:GO:0016559 peroxisome fission [PMID:7860627|PMID:7721939]" /note="Peroxisomal protein required for medium-chain fatty acid oxidation; also required for peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p" /db_xref="GeneID:854018" /db_xref="SGD:S000005507" ORIGIN 1 mvcdtlvyhp svtrfvkfld gsagrekvlr llqylarfla vqnssllarq lqaqfttvrk 61 flrflkplnh lqaaakfydn klasdnvvrv cnvlkniffa aylsldqvnl lrilkvipvt 121 vltgkkiprw snwcwlfgll sglamdlrki qtshaqiaaf vkaksqsqgd ehedhkkvlg 181 kayqdrytal rrlfwdaads fivlnnlgyl ssneeyvals gvvtsilgmq dmwkat // LOCUS NP_014495 194 aa linear PLN 30-JUN-2025 DEFINITION DNA replication protein PSF3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014495 VERSION NP_014495.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183400.1 REFERENCE 1 (residues 1 to 194) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 194) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 194) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 194) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 194) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10639. On Oct 2, 2003 this sequence version replaced NP_014495.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..194 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..194 /product="DNA replication protein PSF3" /calculated_mol_wt="21821" Region 1..194 /region_name="COG5138" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227467" Site order(106,109,128,132,136..137,169,172,174,176..186) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:212551" CDS 1..194 /gene="PSF3" /locus_tag="YOL146W" /coded_by="NM_001183400.1:1..585" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:genetic interaction:GO:0006261 DNA-templated DNA replication [PMID:12730134]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:physical interaction:GO:0000811 GINS complex [PMID:12730134|PMID:12768207]" /experiment="EXISTENCE:physical interaction:GO:0031261 DNA replication preinitiation complex [PMID:12730134]" /note="Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery" /db_xref="GeneID:854019" /db_xref="SGD:S000005506" ORIGIN 1 mgyydiddvl adgtefpckf qydipglgyl ennpgrpitk ntklslplwl arilaivggd 61 ealvdeepvp fvellppdmf stkvmnaikt dpvaldlhsi nshffslaik wimlfsekel 121 anvvselllq raqelnhhas slsidlnads tgknsantni atstfllkle emekeiykks 181 hesykdtkrw mfkk // LOCUS NP_014496 1077 aa linear PLN 30-JUN-2025 DEFINITION Ctr9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014496 VERSION NP_014496.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183399.2 REFERENCE 1 (residues 1 to 1077) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1077) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1077) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1077) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1077) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1077) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1077) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1077) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1077) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10640. On Apr 26, 2011 this sequence version replaced NP_014496.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1077 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1077 /product="Ctr9p" /calculated_mol_wt="124579" Region 59..321 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 194..491 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 217..247 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(346..347,349,373,376..377,380..381,383..384,407, 410..411,414..415,434) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 371..401 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 406..450 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 457..496 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 461..527 /region_name="TPR_12" /note="Tetratricopeptide repeat; pfam13424" /db_xref="CDD:315987" Region 501..527 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 615..915 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 697..726 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 731..759 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 768..796 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region <830..>1058 /region_name="PTZ00121" /note="MAEBL; Provisional" /db_xref="CDD:173412" CDS 1..1077 /gene="CTR9" /locus_tag="YOL145C" /gene_synonym="CDP1" /coded_by="NM_001183399.2:1..3234" /experiment="EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:15531585]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247|PMID:10219085|PMID:15643076]" /experiment="EXISTENCE:direct assay:GO:0045142 triplex DNA binding [PMID:11058104]" /experiment="EXISTENCE:direct assay:GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding [PMID:22796944]" /experiment="EXISTENCE:direct assay:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:20299458]" /experiment="EXISTENCE:genetic interaction:GO:0006360 transcription by RNA polymerase I [PMID:20299458]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:11927560]" /experiment="EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:21737840]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10219085]" /experiment="EXISTENCE:mutant phenotype:GO:0001015 snoRNA transcription by RNA polymerase II [PMID:16246725]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:10219085]" /experiment="EXISTENCE:mutant phenotype:GO:0006362 transcription elongation by RNA polymerase I [PMID:19164765]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:15149594]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:16246725]" /experiment="EXISTENCE:mutant phenotype:GO:0060260 regulation of transcription initiation by RNA polymerase II [PMID:18194564]" /experiment="EXISTENCE:mutant phenotype:GO:1901525 negative regulation of mitophagy [PMID:31525119]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:11884586]" /experiment="EXISTENCE:physical interaction:GO:0003712 transcription coregulator activity [PMID:11927560]" /experiment="EXISTENCE:physical interaction:GO:0016593 Cdc73/Paf1 complex [PMID:11884586|PMID:11927560|PMID:10219085]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11927560]" /note="Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats" /db_xref="GeneID:854020" /db_xref="SGD:S000005505" ORIGIN 1 mtnamkvegy psmewptsld iplkaseelv gidletdlpd dptdlktllv eensekehwl 61 tialaycnhg ktnegiklie maldvfqnse raslhtfltw ahlnlakgqs lsvetkehel 121 tqaelnlkda igfdptwign mlatvelyyq rghydkalet sdlfvksiha edhrsgrqsk 181 pnclflllra kllyqkknym aslkifqell vinpvlqpdp rigiglcfwq lkdskmaiks 241 wqralqlnpk ntsasilvll gefresftns tndktfkeaf tkalsdlnni fsenqhnpvl 301 ltllqtyyyf kgdyqtvldi yhhrilkmsp miakivlses sfwcgrahya lgdyrksfim 361 fqeslkkned nllaklglgq tqiknnllee siitfenlyk tneslqelny ilgmlyagka 421 fdaktaknts akeqsnlnek alkylerylk ltlatknqlv israylvisq lyelqnqykt 481 sldylskale emefikkeip levlnnlacy hfingdfika ddlfkqakak vsdkdesvni 541 tleyniartn ekndcekses iysqvtslhp ayiaarirnl ylkfaqskie dsdmstemnk 601 lldlnksdle irsfygwylk nskerknnek stthnketlv kynshdayal islanlyvti 661 ardgkksrnp keqekskhsy lkaiqlyqkv lqvdpfnifa aqglaiifae skrlgpalei 721 lrkvrdsldn edvqlnlahc ylemreygka ienyelvlkk fdnektrphi lnllgrawya 781 raikersvnf yqkalenakt aldlfvkess kskfihsvkf niallhfqia etlrrsnpkf 841 rtvqqikdsl eglkeglelf relndlkefn mipkeeleqr iqlgettmks alerslneqe 901 efekeqsaki dearkileen elkeqgwmkq eeearrlkle kqaeeyrklq deaqkliqer 961 eamaisehnv kddsdlsdkd neydeekprq krkrstktkn sgeskrrkaa kktlsdsded 1021 dddvvkkpsh nkgkksqlsn efiedsdeee aqmsgseqnk nddndenndn ddndglf // LOCUS NP_014497 484 aa linear PLN 30-JUN-2025 DEFINITION Nop8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014497 VERSION NP_014497.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183398.1 REFERENCE 1 (residues 1 to 484) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 484) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 484) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 484) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10641. Method: conceptual translation. FEATURES Location/Qualifiers source 1..484 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..484 /product="Nop8p" /calculated_mol_wt="56835" Region 8..82 /region_name="RRM_NOL8" /note="RNA recognition motif (RRM) found in nucleolar protein 8 (NOL8) and similar proteins; cd12226" /db_xref="CDD:409673" CDS 1..484 /gene="NOP8" /locus_tag="YOL144W" /coded_by="NM_001183398.1:1..1455" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9891085]" /experiment="EXISTENCE:direct assay:GO:0008428 ribonuclease inhibitor activity [PMID:21747919]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9891085]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:9891085]" /note="Nucleolar protein required for 60S ribosomal subunit biogenesis" /db_xref="GeneID:854021" /db_xref="SGD:S000005504" ORIGIN 1 mdsviqkrif vgnifhnadd cyselldrfg kfgdcqdfqf ekhnhfafid irfndeadfn 61 klrksfnnvk fkgnilkvde akpnwestwa vqhakdlked iilnakmkkk nwqhykkmen 121 vakswkdhke viagrmreap rkrsqlrnit frinvngslk vykcyktklw gyernkelnd 181 lvykftnnfw kngynhivdr ldysravktv rfknglkqlt vskdenvcsg emdsdenmse 241 eekeknnvil ndllkdfdfd kpmtlndsde ellteqrkge eeeeeeeeke vnapeyenvn 301 ktkdqstlpq ekpeerkeqd egdgqednef iptftkeigq gtisntetlr nlfnpneaep 361 vsqfklieds dndidhakdv dvnqleeevs kssdtlglts apvphvsrdk dnknflffph 421 lqspflvgqt qlskvrapgr etmlsnwdee fwanrgnwtr dmrrkmkdal khrkrkqsks 481 glll // LOCUS NP_014498 169 aa linear PLN 30-JUN-2025 DEFINITION lumazine synthase RIB4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014498 VERSION NP_014498.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183397.1 REFERENCE 1 (residues 1 to 169) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 169) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 169) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 169) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 169) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10642. Method: conceptual translation. FEATURES Location/Qualifiers source 1..169 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..169 /product="lumazine synthase RIB4" /EC_number="2.5.1.78" /calculated_mol_wt="18424" Region 18..164 /region_name="lumazine-synth" /note="6,7-dimethyl-8-ribityllumazine synthase; TIGR00114" /db_xref="CDD:211550" Site order(21,27,56..59,62..63,65..67,69..71,73,82,93,95..96,98, 100..101,103..105,107..109,111..115,118..119,123,125,127, 129,133,137,149,152,156,159..160) /site_type="other" /note="homopentamer interface [polypeptide binding]" /db_xref="CDD:187742" Site order(27..28,60..63,89..94,96,98..99,122..126,137,149,152) /site_type="active" /db_xref="CDD:187742" CDS 1..169 /gene="RIB4" /locus_tag="YOL143C" /coded_by="NM_001183397.1:1..510" /experiment="EXISTENCE:direct assay:GO:0000906 6,7-dimethyl-8-ribityllumazine synthase activity [PMID:7559556]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:mutant phenotype:GO:0009231 riboflavin biosynthetic process [PMID:7559556|PMID:5366000]" /note="Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase" /db_xref="GeneID:854022" /db_xref="SGD:S000005503" ORIGIN 1 mavkglgkpd qvydgskirv giiharwnrv iidalvkgai ermaslgvee nniiietvpg 61 syelpwgtkr fvdrqaklgk pldvvipigv likgstmhfe yisdstthal mnlqekvdmp 121 vifglltcmt eeqalaragi deahsmhnhg edwgaaavem avkfgknaf // LOCUS NP_014499 240 aa linear PLN 30-JUN-2025 DEFINITION exosome non-catalytic core subunit RRP40 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014499 VERSION NP_014499.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183396.2 REFERENCE 1 (residues 1 to 240) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 240) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 240) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 240) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10643. On Apr 26, 2011 this sequence version replaced NP_014499.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..240 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..240 /product="exosome non-catalytic core subunit RRP40" /calculated_mol_wt="26425" Region 12..63 /region_name="Rrp40_N" /note="Exosome complex exonuclease Rrp40 N-terminal domain; pfam18311" /db_xref="CDD:436400" Region 63..150 /region_name="S1_Rrp40" /note="Rrp40 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in...; cd05790" /db_xref="CDD:240216" Site order(63,87,92..93,115..117) /site_type="other" /note="subunit interface [polypeptide binding]" /db_xref="CDD:240216" Site order(77,85,96,98) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240216" Region 152..231 /region_name="KH-I_Rrp40" /note="type I K homology (KH) RNA-binding domain found in exosome complex component Rrp40 and similar proteins; cd22526" /db_xref="CDD:411954" Site order(152..154,205) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:411954" CDS 1..240 /gene="RRP40" /locus_tag="YOL142W" /gene_synonym="MTR14" /coded_by="NM_001183396.2:1..723" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:17391830]" /experiment="EXISTENCE:direct assay:GO:0030145 manganese ion binding [PMID:17159918]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15828860|PMID:17643380]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10465791|PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:10465791]" /note="Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; mutations in the human homolog, EXOSC3, cause pontocerebellar hypoplasia with motor neuron degeneration" /db_xref="GeneID:854023" /db_xref="SGD:S000005502" ORIGIN 1 mstfifpgds fpvdpttpvk lgpgiycdpn tqeirpvntg vlhvsakgks gvqtayidys 61 skryipsvnd fvigviigtf sdsykvslqn fsssvslsym afpnaskknr ptlqvgdlvy 121 arvctaekel eaeiecfdst tgrdagfgil edgmiidvnl nfarqllfnn dfpllkvlaa 181 htkfevaigl ngkiwvkcee lsntlacyrt imeccqkndt aafkdiakrq fkeiltvkee // LOCUS NP_014500 695 aa linear PLN 30-JUN-2025 DEFINITION tRNA methyltransferase PPM2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014500 VERSION NP_014500.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183395.2 REFERENCE 1 (residues 1 to 695) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 695) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 695) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 695) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 695) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10644. On Apr 26, 2011 this sequence version replaced NP_014500.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..695 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..695 /product="tRNA methyltransferase PPM2" /EC_number="2.1.1.290" /EC_number="2.3.1.231" /calculated_mol_wt="78826" Region 7..241 /region_name="LCM" /note="Leucine carboxyl methyltransferase; pfam04072" /db_xref="CDD:427692" Region <395..>512 /region_name="NanM" /note="N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; COG3055" /db_xref="CDD:442289" Region 439..486 /region_name="Kelch_4" /note="Galactose oxidase, central domain; pfam13418" /db_xref="CDD:433191" Region 440..487 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" CDS 1..695 /gene="PPM2" /locus_tag="YOL141W" /gene_synonym="TYW4" /coded_by="NM_001183395.2:1..2088" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0008175 tRNA methyltransferase activity [PMID:16642040]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:16642040]" /experiment="EXISTENCE:mutant phenotype:GO:0008175 tRNA methyltransferase activity [PMID:16642040]" /experiment="EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:16642040]" /experiment="EXISTENCE:mutant phenotype:GO:0031591 wybutosine biosynthetic process [PMID:17150819|PMID:16642040]" /note="AdoMet-dependent tRNA methyltransferase; also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p" /db_xref="GeneID:854024" /db_xref="SGD:S000005501" ORIGIN 1 mknlttikqt nknvkqerrk kyadlaiqgt nnssiaskrs vellylpkls sannfqmdkn 61 nklleyfkff vpkkikrspc inrgywlrlf airsrlnsii eqtpqdkkiv vvnlgcgydp 121 lpfqlldtnn iqsqqyhdrv sfididysdl lkikielikt ipelskiigl sedkdyvdds 181 nvdflttpky larpcdlnds kmfstllnec qlydpnvvkv fvaevslaym kpersdsiie 241 atskmenshf iileqlipkg pfepfskqml ahfkrndspl qsvlkyntie sqvqrfnklg 301 fayvnvgdmf qlwesadeat kkellkvepf deleefhlfc hhyvlchatn ykefaftqgf 361 lfdrsisein ltvdedyqll ececpinrkf gdvdvagndv fymggsnpyr vneilqlsih 421 ydkidmknie vsssevpvar mchtfttisr nnqllliggr kaphqglsdn wifdmktrew 481 smikslshtr frhsacslpd gnvlilggvt egpamllynv teeifkdvtp kdeffqnslv 541 saglefdpvs kqgiilgggf mdqttvsdka iifkydaena tepitvikkl qhplfqrygs 601 qikyitprkl livggtspsg lfdrtnsiis ldplsetlts ipisrriwed hslmlagfsl 661 vstsmgtihi igggatcygf gsvtnvglkl iaiak // LOCUS NP_014501 423 aa linear PLN 30-JUN-2025 DEFINITION acetylornithine transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014501 VERSION NP_014501.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183394.1 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10645. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..423 /product="acetylornithine transaminase" /EC_number="2.6.1.11" /calculated_mol_wt="46550" Region 23..418 /region_name="argD" /note="transaminase, acetylornithine/succinylornithine family; TIGR00707" /db_xref="CDD:273228" CDS 1..423 /gene="ARG8" /locus_tag="YOL140W" /coded_by="NM_001183394.1:1..1272" /experiment="EXISTENCE:direct assay:GO:0003992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity [PMID:2199330]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:205532]" /note="Acetylornithine aminotransferase; catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine" /db_xref="GeneID:854025" /db_xref="SGD:S000005500" ORIGIN 1 mfkrylssts srrftsilee kafqvttysr pedlcitrgk naklyddvng keyidftagi 61 avtalghanp kvaeilhhqa nklvhssnly ftkecldlse kivektkqfg gqhdasrvfl 121 cnsgteanea alkfakkhgi mknpskqgiv afensfhgrt mgalsvtwns kyrtpfgdlv 181 phvsflnlnd emtklqsyie tkkdeiagli vepiqgeggv fpvevekltg lkkicqdndv 241 ivihdeiqcg lgrsgklwah aylpseahpd iftsakalgn gfpiaativn ekvnnalrvg 301 dhgttyggnp lacsvsnyvl dtiadeaflk qvskksdilq krlreiqaky pnqiktirgk 361 glmlgaefve pptevikkar elglliitag kstvrfvpal tiedelieeg mdafekaiea 421 vya // LOCUS NP_014502 213 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF4E [Saccharomyces cerevisiae S288C]. ACCESSION NP_014502 VERSION NP_014502.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183393.1 REFERENCE 1 (residues 1 to 213) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 213) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 213) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 213) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10646. Method: conceptual translation. FEATURES Location/Qualifiers source 1..213 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..213 /product="translation initiation factor eIF4E" /calculated_mol_wt="24123" Region 1..213 /region_name="CDC33" /note="Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis]; COG5053" /db_xref="CDD:227386" CDS 1..213 /gene="CDC33" /locus_tag="YOL139C" /gene_synonym="TIF45" /coded_by="NM_001183393.1:1..642" /experiment="EXISTENCE:direct assay:GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [PMID:15753296]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8119957]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8119957]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:18981231|PMID:17908917]" /experiment="EXISTENCE:direct assay:GO:0016281 eukaryotic translation initiation factor 4F complex [PMID:15753296]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:16343487]" /experiment="EXISTENCE:direct assay:GO:0098808 mRNA cap binding [PMID:24183571]" /experiment="EXISTENCE:direct assay:GO:1901195 positive regulation of formation of translation preinitiation complex [PMID:30281017]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:2540596]" /note="Translation initiation factor eIF4E; mRNA cap binding protein and subunit of the mRNA cap-binding complex (eIF4F) along with eIF4A and eIF4G, that mediates cap-dependent translation; required with eIF4G for Ded1p-mediated stimulation of mRNA recruitment during 48S preinitiation complex (PIC) assembly; connects protein synthesis to metabolic gene regulation; protein abundance increases in response to DNA replication stress; human homolog EIF4E can complement cdc33 mutants" /db_xref="GeneID:854026" /db_xref="SGD:S000005499" ORIGIN 1 msveevskkf eenvsvddtt atpktvlsds ahfdvkhpln tkwtlwytkp avdkseswsd 61 llrpvtsfqt veefwaiiqn ipephelplk sdyhvfrndv rpewedeana kggkwsfqlr 121 gkgadidelw lrtllavige tideddsqin gvvlsirkgg nkfalwtkse dkepllrigg 181 kfkqvlkltd dghleffphs sangrhpqps itl // LOCUS NP_014503 1341 aa linear PLN 30-JUN-2025 DEFINITION Rtc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014503 VERSION NP_014503.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183392.2 REFERENCE 1 (residues 1 to 1341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1341) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10647. On Apr 26, 2011 this sequence version replaced NP_014503.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1341 /product="Rtc1p" /calculated_mol_wt="149213" Region 202..396 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 213..256 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 261..298 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 329..366 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1292..1336 /region_name="mRING-H2-C3H3C2_Mio-like" /note="Modified RING finger, H2 subclass (C3H3C2-type), found in WD repeat-containing protein mio and its homologs; cd16488" /db_xref="CDD:438151" CDS 1..1341 /gene="RTC1" /locus_tag="YOL138C" /gene_synonym="SEA2" /coded_by="NM_001183392.2:1..4026" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0035859 Seh1-associated complex [PMID:21454883]" /experiment="EXISTENCE:genetic interaction:GO:1904263 positive regulation of TORC1 signaling [PMID:23716719]" /note="Subunit of SEACAT, a subcomplex of the SEA complex; Rtc1p, along with Mtc5p and Sea4p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; null suppresses cdc13-1" /db_xref="GeneID:853982" /db_xref="SGD:S000005498" ORIGIN 1 mslsphvena sipkgstpip knrnvssigk geflgssssn nssfrmnhys nsgqpsvlds 61 irrpnltptf sysngvympe shrtssfnds ylpydknpya kttgsmsnks nmkiktkkna 121 intntrkssg liyttkvdke lssidkvndp ninglvcagk thlglykfsp sdrsikcvhd 181 fitpnsntst rgttsllpkl skrtrqnkfs tiadvktgfn nyknciavcn nstaisiydl 241 nksssidnpl itslcehtrs insfdfnmve snliisggqd scvkiwdlrs nkskssnrsd 301 isintasdsi rdvkwmpgyn faskndqgss tygnlksgyk fasihdsgyl lkfdlrqpaq 361 yekklnahtg pglclnwhpn qeyiatggrd gkcclwfvgd nanaaentvl nygnspslha 421 pntslnnsgs lafpkltint gypvtklkfk payssniyns llgissmgde aevriyslar 481 kyipkhvlls etpslglvww denlifnidk gtringwdin keptvlenls kntttwrdld 541 gngllsvdqe igsyevvepe lqptssttck khpgtiknpk ngnpenqgii ggikkgfsht 601 gltsftperp ptlkagptfs tksltlasga ssfnsssasl tsltpqtenr eeiaieppci 661 itldipqifn nirltkiahs rkknvisess smknspvekf kylarqlkfs yirehnvsds 721 adtaykndie nidvvknate thgdnttttn nnddgddddd dddddkiies hllkkynfpe 781 nntwatlmne kvnnkkskrn ssssrefdek dvrssissis asrqshdrar kidknveael 841 qekiqtlvdl isiathnasv ylsiddltnf kiwilirdsl lwdlkwmtss qissdnasnm 901 danessdfea genlktgkef peedgagtsg aeslveerpq afransdeps daekkpvskl 961 keqlknteii pyaqpnedsd evltklkelq nqrlesrtkm getvsddvii eedehehqee 1021 eqphdsptks aqfhaspiak sipilqkreh rksfidtfml hspngyngdt digneddnis 1081 prftynsvsp rskvsslqsy atttsqletf kklsshtapi igsprhapsr pdsigreqls 1141 ssltkklakc kkiiadppwd tkklikqlyn qatetgnvvl tvnilflfqt iyqiteidia 1201 kdaiahflll lhryelfgia advlkycpfe dimgsegdqs sirlfcercg elitnesske 1261 klraeaqqtg nkkimdkfgy wycdsckkkn tscvlcerpl kkltmvilpc gheghfqciq 1321 ewfldeneqe cpggcpgvaf i // LOCUS NP_014504 497 aa linear PLN 30-JUN-2025 DEFINITION Bsc6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014504 VERSION NP_014504.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183391.1 REFERENCE 1 (residues 1 to 497) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 497) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 497) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 497) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10648. Method: conceptual translation. FEATURES Location/Qualifiers source 1..497 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..497 /product="Bsc6p" /calculated_mol_wt="54954" Region 84..485 /region_name="MFS_FucP_MFSD4_like" /note="Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; cd17333" /db_xref="CDD:340891" Site order(91..92,95..96,99,131,182..183,185..187,190,208, 211..212,215,310,313..314,317..319,322,350,354,413..414, 418,422,439,442..443,446..447,450) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340891" CDS 1..497 /gene="BSC6" /locus_tag="YOL137W" /coded_by="NM_001183391.1:1..1494" /experiment="EXISTENCE:direct assay:GO:0030136 clathrin-coated vesicle [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:14562095]" /note="hypothetical protein with 8 putative transmembrane segments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression" /db_xref="GeneID:853983" /db_xref="SGD:S000005497" ORIGIN 1 mdassvppkv ddygmyttei shhnpielkn llsssdsrrn sqdedslpnn tnlikeidwq 61 gekvktypln yqtvplvklq viaclimfvv fgmndqtvga llptlieyyh isrvdvsnvf 121 ivqlcgyvma slskerlnkh fgmrggmlla aglcivflii latapssfyv cmfcglplgl 181 gigildstgn vlmgsllvhk nelmgimhgl ygaaamvtpp lvsyfvewgh wslffliplf 241 fsiigmivif pafkfetask ydylcsvenk esnndveeag dnslmestka spgffellrn 301 paiflyslyl flylgaeitt gswffsylle tkssnkvams yiaasfwtgl tvgrlclgfv 361 terffeneyk askayafltl ssytlfvlvg linsssvfyf vvlffvvfcc gtfigplfpn 421 asivalqvlp krlhvsgvgv avavggcgga aipylagvia htvgiqyipl lcwimvalft 481 lewtlypkfi kgheeyf // LOCUS NP_014505 397 aa linear PLN 30-JUN-2025 DEFINITION 6-phosphofructo-2-kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014505 VERSION NP_014505.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183390.1 REFERENCE 1 (residues 1 to 397) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 397) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 397) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 397) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10649. Method: conceptual translation. FEATURES Location/Qualifiers source 1..397 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..397 /product="6-phosphofructo-2-kinase" /EC_number="2.7.1.105" /calculated_mol_wt="45187" Region 84..324 /region_name="6PF2K" /note="6-phosphofructo-2-kinase; pfam01591" /db_xref="CDD:396253" CDS 1..397 /gene="PFK27" /locus_tag="YOL136C" /coded_by="NM_001183390.1:1..1194" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:8861205]" /experiment="EXISTENCE:mutant phenotype:GO:0006003 fructose 2,6-bisphosphate metabolic process [PMID:8861205]" /experiment="EXISTENCE:mutant phenotype:GO:0006110 regulation of glycolytic process [PMID:8861205]" /note="6-phosphofructo-2-kinase; catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A" /db_xref="GeneID:853984" /db_xref="SGD:S000005496" ORIGIN 1 mggssdsdsh dgyltseyns snslfslntg nsyssasldr atldcqdsvf fdnhksslls 61 tevprfisnd plhlpitlny krdnadptyt ngkvnkfmiv liglpatgks tisshliqcl 121 knnpltnslr ckvfnagkir rqiscatisk plllsntsse dlfnpknndk ketyaritlq 181 klfheinnde cdvgifdatn stierrrfif eevcsfntde lssfnlvpii lqvscfnrsf 241 ikynihnksf nedyldkpye laikdfakrl khyysqftpf sldefnqihr yisqheeidt 301 slfffnvina gvvephslnq shypstcgkq irdtimvien finhysqmfg feyieavklf 361 fesfgnssee tlttldsvvn dkffddlqsl iesngfa // LOCUS NP_014506 222 aa linear PLN 30-JUN-2025 DEFINITION mediator complex subunit MED7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014506 VERSION NP_014506.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183389.1 REFERENCE 1 (residues 1 to 222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 222) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10650. Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..222 /product="mediator complex subunit MED7" /calculated_mol_wt="25454" Region 21..203 /region_name="Med7" /note="MED7 protein; pfam05983" /db_xref="CDD:461794" CDS 1..222 /gene="MED7" /locus_tag="YOL135C" /coded_by="NM_001183389.1:1..669" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:19057509]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16452140]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" /db_xref="GeneID:853985" /db_xref="SGD:S000005495" ORIGIN 1 msndpgnevs slypppppyv kfftqsnlek lpkykekkaa sakqtapnns nggseeeitc 61 aldylipppm pknqqyrafg siwqvkdqlp dlesmgltql ykkstenest nyqykiqelr 121 kllkslllny leligvlsin pdmyerkven irtilvnihh llneyrphqs reslimllee 181 qleykrgeir eieqvckqvh dkltsiqdtl rtgsqsppss sq // LOCUS NP_014508 121 aa linear PLN 30-JUN-2025 DEFINITION SCF ubiquitin ligase complex subunit HRT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014508 VERSION NP_014508.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183387.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10651. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..121 /product="SCF ubiquitin ligase complex subunit HRT1" /calculated_mol_wt="13809" Region 33..121 /region_name="APC11" /note="Component of SCF ubiquitin ligase and anaphase-promoting complex [Posttranslational modification, protein turnover, chaperones / Cell division and chromosome partitioning]; COG5194" /db_xref="CDD:227521" Site order(85,87,89,94,98,102) /site_type="other" /note="cullin binding site [polypeptide binding]" /db_xref="CDD:438148" CDS 1..121 /gene="HRT1" /locus_tag="YOL133W" /gene_synonym="HRT2; RBX1; ROC1" /coded_by="NM_001183387.1:1..366" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:10385629]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10385629]" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:10385629|PMID:19882662]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:10213692]" /experiment="EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:10385629]" /experiment="EXISTENCE:direct assay:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:12676951]" /experiment="EXISTENCE:direct assay:GO:0035361 Cul8-RING ubiquitin ligase complex [PMID:12676951]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:10230407]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:10385629]" /experiment="EXISTENCE:physical interaction:GO:0019005 SCF ubiquitin ligase complex [PMID:10385629]" /note="RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair" /db_xref="GeneID:853986" /db_xref="SGD:S000005493" ORIGIN 1 msnevdrmdv dedesqniaq ssnqsapvet kkkrfeikkw tavafwswdi avdncaicrn 61 himepciecq pkamtdtdne cvaawgvcnh afhlhcinkw iktrdacpld nqpwqlarcg 121 r // LOCUS NP_014509 471 aa linear PLN 30-JUN-2025 DEFINITION 1,3-beta-glucanosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014509 VERSION NP_014509.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183386.1 REFERENCE 1 (residues 1 to 471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 471) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10652. Method: conceptual translation. FEATURES Location/Qualifiers source 1..471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..471 /product="1,3-beta-glucanosyltransferase" /calculated_mol_wt="53682" Region 15..335 /region_name="Glyco_hydro_72" /note="Glucanosyltransferase; pfam03198" /db_xref="CDD:397351" CDS 1..471 /gene="GAS4" /locus_tag="YOL132W" /coded_by="NM_001183386.1:1..1416" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0042124 1,3-beta-glucanosyltransferase activity [PMID:17397106]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:17189486]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:17189486]" /note="1,3-beta-glucanosyltransferase; involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall" /db_xref="GeneID:853988" /db_xref="SGD:S000005492" ORIGIN 1 mmvfsstfif lilelvvlce asvhtiqikd khfvdtvtgk pffikgvdyq pggssdvsek 61 qdplsnpdac ardillfqel gintvriysi npdlnhdacm tmlamagiyl ildvnsplqn 121 qhlnryepwt tynevylehv fkvveqfshy nntlgffagn eivndkrsaq yspayvkeli 181 gtmknyisah sprtipvgys aaddlnyrvs lseyleckdd dkpensvdfy gvnsyqwcgq 241 qtmqtsgydt lvdayrsysk pvffsefgcn kvlprqfqei gylfseemys vfcgglvyef 301 sqednnyglv eyqeddsvql ladfeklksh yqniefpsmk tlketvqmee tpscaedyen 361 lkieskiakn lgsslikkgv kvekgkyidi hedqlstnvt ildkhgdrwn gpkkieirqs 421 ltladlegee qedadedkdd lkrkhrnsas isgpllplgl cllfftfslf f // LOCUS NP_014510 108 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL131W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014510 VERSION NP_014510.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183385.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10653. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..108 /product="uncharacterized protein" /calculated_mol_wt="12292" CDS 1..108 /locus_tag="YOL131W" /coded_by="NM_001183385.1:1..327" /note="hypothetical protein; YOL131W has a paralog, STB1, that arose from the whole genome duplication" /db_xref="GeneID:853989" /db_xref="SGD:S000005491" ORIGIN 1 mntnkiaqde vqdkvlqrae lahsvwnlrf nlskvakrir metkvfpeik indaqsqler 61 srcrifspdl eeehvpliqg fkcldspppv ppsssqgede entvdsqy // LOCUS NP_014511 859 aa linear PLN 30-JUN-2025 DEFINITION Mg(2+) transporter ALR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014511 VERSION NP_014511.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183384.1 REFERENCE 1 (residues 1 to 859) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 859) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 859) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 859) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10654. Method: conceptual translation. FEATURES Location/Qualifiers source 1..859 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..859 /product="Mg(2+) transporter ALR1" /calculated_mol_wt="95739" Region 456..779 /region_name="Alr1p-like" /note="Saccharomyces cerevisiae Alr1p-like subfamily; cd12829" /db_xref="CDD:213363" Site order(479,482..483,492,494,544,548,562,565,573,576,580, 586..587,590,605..606,609,612..613,616,620,691..692, 694..695,698..699,701..702,705..706,708..709,711..713, 723..730,732..744,746..748,750..755,757..764,773..774, 777..778) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:213363" Site order(548,562) /site_type="other" /note="putative Cl binding site [ion binding]" /db_xref="CDD:213363" Site order(740,743) /site_type="other" /note="hydrophobic gate" /db_xref="CDD:213363" Site order(758,760..761) /site_type="other" /note="periplasmic entrance" /db_xref="CDD:213363" CDS 1..859 /gene="ALR1" /locus_tag="YOL130W" /gene_synonym="SWC3" /coded_by="NM_001183384.1:1..2580" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21738593]" /experiment="EXISTENCE:direct assay:GO:0015693 magnesium ion transport [PMID:12167543]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:9430719]" /experiment="EXISTENCE:mutant phenotype:GO:0006812 monoatomic cation transport [PMID:9430719]" /experiment="EXISTENCE:mutant phenotype:GO:0022890 inorganic cation transmembrane transporter activity [PMID:9430719]" /note="Plasma membrane Mg(2+) transporter; expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; magnesium transport defect of the null mutant is functionally complemented by either of the human genes MAGT1 and TUSC3 that are not orthologous to ALR1" /db_xref="GeneID:853990" /db_xref="SGD:S000005490" ORIGIN 1 mssssssses spnlsrsnsl antmvsmkte dhtglydhrq hpdslpvrhq pptlknkeia 61 kstkpsipke qksatrynsh vdvgsvpsrg rmdfedegqg mdetvahhql rasailtsna 121 rpsrlahsmp hqrqlyvesn ihtppkdvgv krdytmssst assgnkskls asssaspitk 181 vrksslvspv leiphesksd thsklakpkk rtysttsahs sinpavlltk stsqksdadd 241 dtlerkpvrm ntrasfdsdv sqasrdsqet eedvcfpmpp qlhtrvngid fdeleeyaqf 301 anaeksqfla slqvpneqky snvsqdigft sststsgssa alkytprvsq tgeksestne 361 teihekkede hekikpslhp gisfgknkve geenenipsn dpaycsyqgt dfqipnrfsf 421 fcsesdetvh asdipslvse gqtfyelfrg geptwwldcs cptddemrci akafgihplt 481 aedirmqetr ekvelfksyy fvcfhtfend kesedflepi nvyivvcrsg vltfhfgpis 541 hcanvrrrvr qlrdyvnvns dwlcyalidd itdsfapviq sieyeadaie dsvfmardmd 601 faamlqrige srrktmtlmr llsgkadvik mfakrcqdea ngigpaltsq inianlqarq 661 dnashiknns sttvpnnyap ttsqprgdia lylgdiqdhl ltmfqnllay ekifsrshtn 721 ylaqlqvesf nsnnkvteml gkvtmigtml vplnvitglf gmnvkvpgen ssiawwfgil 781 gvllllavlg wflasywikr idppatlnea aesgaksvis sflpkrnkrf ndrskninvr 841 agpsnksvas lpsrysryd // LOCUS NP_014512 184 aa linear PLN 30-JUN-2025 DEFINITION Vps68p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014512 VERSION NP_014512.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183383.1 REFERENCE 1 (residues 1 to 184) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 184) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 184) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 184) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 184) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10655. Method: conceptual translation. FEATURES Location/Qualifiers source 1..184 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..184 /product="Vps68p" /calculated_mol_wt="19970" Region 11..178 /region_name="UPF0220" /note="Uncharacterized protein family (UPF0220); pfam05255" /db_xref="CDD:428395" CDS 1..184 /gene="VPS68" /locus_tag="YOL129W" /coded_by="NM_001183383.1:1..555" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:23708375]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:39271159]" /experiment="EXISTENCE:direct assay:GO:0034424 Vps55/Vps68 complex [PMID:18216282]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:18216282]" /experiment="EXISTENCE:physical interaction:GO:0034424 Vps55/Vps68 complex [PMID:18216282]" /note="Vacuolar membrane hypothetical protein; involved in vacuolar protein sorting; also detected in the mitochondria" /db_xref="GeneID:853991" /db_xref="SGD:S000005489" ORIGIN 1 meaddhvslf rfpfkiptfr girkggvyls galyalgfwi fldavlysry snasdvhvtf 61 idwipflcst lgtlivnsie knrllqgals sdggafgsgv gdldssmawq artvlffgfa 121 llagglsgsi vvliikflvk dyntyptlgm gvnnvlgnvc illscvvlwi aqnvedeysy 181 sltl // LOCUS NP_014513 375 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase YGK3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014513 VERSION NP_014513.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183382.1 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10656. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..375 /product="serine/threonine protein kinase YGK3" /EC_number="2.7.11.1" /calculated_mol_wt="43075" Region 35..332 /region_name="STKc_GSK3" /note="The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; cd14137" /db_xref="CDD:271039" Site order(47..51,55,72,74,85,99,124..127,130,132..133,173,175, 177..178,180,192,195,206,208..211,213,251) /site_type="active" /db_xref="CDD:271039" Site order(47..50,55,72,74,99,124..127,130,175,177..178,180,192) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271039" Site order(51..52,204..212,220..221,252..256,258..259,263, 282..285) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:271039" Site order(85,132,173,175,195,206,208..211,213,251) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271039" Site order(191..201,203..213) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271039" Site order(220,255..256,258..259,262..263,282..287) /site_type="other" /note="axin binding site [polypeptide binding]" /db_xref="CDD:271039" CDS 1..375 /gene="YGK3" /locus_tag="YOL128C" /coded_by="NM_001183382.1:1..1128" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:10958669]" /experiment="EXISTENCE:mutant phenotype:GO:0006508 proteolysis [PMID:10958669]" /note="Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication" /db_xref="GeneID:853992" /db_xref="SGD:S000005488" ORIGIN 1 mlkvnnvfgs npnrmtkled ehyfiddivs iknrqkskmy vregkrighg sfgtvtqsil 61 ssnsiewlgp yaikrvvksp kvqsleleil qnirhpnlvt lefffeshct tkdgghlyqk 121 nfvmeyipqt lsseiheyfd ngskmptkhi klytfqilra lltlhsmsic hgdlkpsnil 181 iipssgiakv cdfgsaqrld dntelktyfc srfyrapell lnskdyttqi diwslgciig 241 emikgqplfk gdsansqlee iakllgrfpk ssiknsqelq dslndqkfkk fmhwfpsief 301 fdvefllkvl tydatercda rqlmaheffd alrnetyflp rgssmpvhlp dlfnfsasek 361 ralgeyynli vpsld // LOCUS NP_014514 142 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL23 RPL25 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014514 VERSION NP_014514.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183381.1 REFERENCE 1 (residues 1 to 142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 142) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10657. Method: conceptual translation. FEATURES Location/Qualifiers source 1..142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..142 /product="60S ribosomal protein uL23 RPL25" /calculated_mol_wt="15626" Region 20..142 /region_name="PTZ00191" /note="60S ribosomal protein L23a; Provisional" /db_xref="CDD:185507" CDS 1..142 /gene="RPL25" /locus_tag="YOL127W" /coded_by="NM_001183381.1:1..429" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:8028007]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23268442]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:8028007]" /note="Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23" /db_xref="GeneID:853993" /db_xref="SGD:S000005487" ORIGIN 1 mapsakataa kkavvkgtng kkalkvrtsa tfrlpktlkl arapkyaska vphynrldsy 61 kvieqpitse tamkkvedgn ilvfqvsmka nkyqikkavk elyevdvlkv ntlvrpngtk 121 kayvrltady daldianrig yi // LOCUS NP_014515 377 aa linear PLN 30-JUN-2025 DEFINITION malate dehydrogenase MDH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014515 VERSION NP_014515.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183380.1 REFERENCE 1 (residues 1 to 377) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 377) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 377) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 377) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 377) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10658. On Oct 10, 2006 this sequence version replaced NP_014515.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..377 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..377 /product="malate dehydrogenase MDH2" /EC_number="1.1.1.37" /calculated_mol_wt="40600" Region 15..372 /region_name="MDH_euk_gproteo" /note="malate dehydrogenase, NAD-dependent; TIGR01772" /db_xref="CDD:130833" CDS 1..377 /gene="MDH2" /locus_tag="YOL126C" /coded_by="NM_001183380.1:1..1134" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:1986231]" /experiment="EXISTENCE:direct assay:GO:0030060 L-malate dehydrogenase (NAD+) activity [PMID:1986231]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0006094 gluconeogenesis [PMID:12730240]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:19118449]" /experiment="EXISTENCE:mutant phenotype:GO:0030060 L-malate dehydrogenase (NAD+) activity [PMID:1986231]" /note="Cytoplasmic malate dehydrogenase; one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1; mutation in human homolog MDH2 causes early-onset severe encephalopathy" /db_xref="GeneID:853994" /db_xref="SGD:S000005486" ORIGIN 1 mphsvtpsie qdslkiailg aaggigqsls lllkaqlqyq lkesnrsvth ihlalydvnq 61 eaingvtadl shidtpisvs shspaggien clhnasivvi pagvprkpgm trddlfnvna 121 giisqlgdsi aeccdlskvf vlvisnpvns lvpvmvsnil knhpqsrnsg ierrimgvtk 181 ldivrastfl reiniesglt prvnsmpdvp vigghsgeti iplfsqsnfl srlnedqlky 241 lihrvqyggd evvkakngkg satlsmahag ykcvvqfvsl llgnieqihg tyyvplkdan 301 nfpiapgadq llplvdgady faipltittk gvsyvdydiv nrmndmernq mlpicvsqlk 361 knidkglefv asrsass // LOCUS NP_014516 476 aa linear PLN 30-JUN-2025 DEFINITION tRNA:m4X modification enzyme [Saccharomyces cerevisiae S288C]. ACCESSION NP_014516 VERSION NP_014516.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183379.2 REFERENCE 1 (residues 1 to 476) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 476) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 476) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 476) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10659. Method: conceptual translation. FEATURES Location/Qualifiers source 1..476 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..476 /product="tRNA:m4X modification enzyme" /EC_number="2.1.1.225" /calculated_mol_wt="53964" Region 19..47 /region_name="zf-TRM13_CCCH" /note="CCCH zinc finger in TRM13 protein; pfam11722" /db_xref="CDD:463331" Region 72..96 /region_name="zf-U11-48K" /note="U11-48K-like CHHC zinc finger; pfam05253" /db_xref="CDD:461603" Region 179..474 /region_name="TRM13" /note="Methyltransferase TRM13; pfam05206" /db_xref="CDD:398743" CDS 1..476 /gene="TRM13" /locus_tag="YOL125W" /coded_by="NM_001183379.2:1..1431" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:17242307]" /experiment="EXISTENCE:direct assay:GO:0106050 tRNA 2'-O-methyltransferase activity [PMID:17242307]" /experiment="EXISTENCE:mutant phenotype:GO:0002128 tRNA nucleoside ribose methylation [PMID:32053677]" /experiment="EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:17242307]" /experiment="EXISTENCE:mutant phenotype:GO:0106050 tRNA 2'-O-methyltransferase activity [PMID:17242307]" /note="2'-O-methyltransferase; responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases" /db_xref="GeneID:853995" /db_xref="SGD:S000005485" ORIGIN 1 mlqdnngpav krakpserlq ceyfmekkkr rcgmtrssqn lycsehlnlm kkaansqvhn 61 kngseaeker ervpcpldpn htvwadqlkk hlkkcnktkl shlnddkpyy epgyngengl 121 lsssvkidit aehlvqsiel lykvfegesm delplrqlnn klmslkrfpq lpsntkhavq 181 qsslienlvd agaferpesl nfiefgcgra efsryvslyl ltqltslpae hsgsnsnefv 241 lidratnrmk fdkkikddfs eiksnspskp iscpsikrik idirdlkmdp ilkstpgddi 301 qyvciskhlc gvatdltlrc ignssilhgd dnngcnpklk aiciamccrh vcdygdyvnr 361 syvtslveky rahgsiltye tffrvltklc swgtcgrkpg taitdivnvv esfegaepyt 421 itikerenig lmarrvideg rlvyvkekft efnaeliryv esdvslenva mlvykk // LOCUS NP_014517 433 aa linear PLN 30-JUN-2025 DEFINITION tRNA (guanine-N2-)-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014517 VERSION NP_014517.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183378.1 REFERENCE 1 (residues 1 to 433) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 433) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 433) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 433) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 433) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10660. Method: conceptual translation. FEATURES Location/Qualifiers source 1..433 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..433 /product="tRNA (guanine-N2-)-methyltransferase" /EC_number="2.1.1.214" /calculated_mol_wt="49942" Region 202..>314 /region_name="Trm11" /note="tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; COG1041" /db_xref="CDD:440663" CDS 1..433 /gene="TRM11" /locus_tag="YOL124C" /coded_by="NM_001183378.1:1..1302" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:15899842]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:15899842]" /experiment="EXISTENCE:direct assay:GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity [PMID:15899842]" /experiment="EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:15899842]" /experiment="EXISTENCE:mutant phenotype:GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity [PMID:15899842]" /experiment="EXISTENCE:physical interaction:GO:0043528 tRNA (m2G10) methyltransferase complex [PMID:15899842]" /note="Catalytic subunit of adoMet-dependent tRNA methyltransferase complex; required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; involved in the methylation of guanosine and uridine ribonucleosides in mRNA; contains a THUMP domain and a methyltransferase domain; methyltransferase complex also contains Trm112p" /db_xref="GeneID:853996" /db_xref="SGD:S000005484" ORIGIN 1 mkkyllymvq vhlnfrrael esladlynls idfsqydans pffivelend qqakdwikrs 61 iltrgiyeyw gqgttldelh kdiqrqsnfe qdlqlkfkhs tfkfefecyk gnskakrveq 121 ietfrylgfe gkidmkhpqe vftvieeytp isenvggktp triyfgrqvq msnrsameky 181 dlkkrpykgt tsfeaelslv saniaqvkpg timydpfagt gsflvagghf gslvigsdid 241 grmirgkgaq vnisanfkky gessqfldvl tmdftnnalr nnlvidtilc dppygiresi 301 kvlgakdper flgkedmeid gekaylrrdy iptkkpyald sllddllqys serlpiggrl 361 afwmptanda nietivpmhe nlelkyncvq efnkwsrrll vyinrgstfn gssnhgikrs 421 kdnfreryfn nfn // LOCUS NP_014518 534 aa linear PLN 30-JUN-2025 DEFINITION Hrp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014518 VERSION NP_014518.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183377.1 REFERENCE 1 (residues 1 to 534) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 534) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 534) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 534) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 534) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10661. Method: conceptual translation. FEATURES Location/Qualifiers source 1..534 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..534 /product="Hrp1p" /calculated_mol_wt="59519" Region <144..463 /region_name="PABP-1234" /note="polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628" /db_xref="CDD:130689" Region 161..236 /region_name="RRM1_Hrp1p" /note="RNA recognition motif 1 (RRM1) found in yeast nuclear polyadenylated RNA-binding protein 4 (Hrp1p or Nab4p) and similar proteins; cd12577" /db_xref="CDD:409991" Site order(162,164..168,189,191,199..202,204,226,229,232..234) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:409991" Region 244..321 /region_name="RRM2_Hrp1p" /note="RNA recognition motif 2 (RRM2) found in yeast nuclear polyadenylated RNA-binding protein 4 (Hrp1p or Nab4p) and similar proteins; cd12330" /db_xref="CDD:409767" Site order(246,248,273,275,286,288,314,316,318) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:409767" CDS 1..534 /gene="HRP1" /locus_tag="YOL123W" /gene_synonym="NAB4; NAB5" /coded_by="NM_001183377.1:1..1605" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9334319]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:17684230|PMID:23222640|PMID:15703440]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15572678|PMID:9334319|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9334319]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11344258]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:18981231]" /experiment="EXISTENCE:mutant phenotype:GO:0072423 response to DNA damage checkpoint signaling [PMID:24603480]" /experiment="EXISTENCE:physical interaction:GO:0005849 mRNA cleavage factor complex [PMID:11344258]" /note="Subunit of cleavage factor I and mRNA guard protein; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; required for genome stability; plays a role in copper homeostasis" /db_xref="GeneID:853997" /db_xref="SGD:S000005483" ORIGIN 1 mssdeedfnd iygddkpttt eevkkeeeqn kagsgtsqld qlaalqalss slnklnnpns 61 nnsssnnsnq dtssskqdgt andkegsned tknekkqesa tsanananas sagpsglpwe 121 qlqqtmsqfq qpssqsppqq qvtqtkeers kadlskesck mfigglnwdt tednlreyfg 181 kygtvtdlki mkdpatgrsr gfgflsfekp ssvdevvktq hildgkvidp kraiprdeqd 241 ktgkifvggi gpdvrpkefe effsqwgtii daqlmldkdt gqsrgfgfvt ydsadavdrv 301 cqnkfidfkd rkieikraep rhmqqkssnn ggnnggnnmn rrggnfgnqg dfnqmyqnpm 361 mggynpmmnp qamtdyyqkm qeyyqqmqkq tgmdytqmyq qqmqqmammm pgfamppnam 421 tlnqpqqdsn atqgspapsd sdnnksndvq tigntsntds gspplnlpng pkgpsqyndd 481 hnsgygynrd rgdrdrndrd rdynhrsggn hrrngrggrg gynrrnngyh pynr // LOCUS NP_014519 575 aa linear PLN 30-JUN-2025 DEFINITION divalent metal ion transporter SMF1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014519 VERSION NP_014519.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183376.1 REFERENCE 1 (residues 1 to 575) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 575) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 575) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 575) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10662. Method: conceptual translation. FEATURES Location/Qualifiers source 1..575 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..575 /product="divalent metal ion transporter SMF1" /calculated_mol_wt="63133" Region 74..490 /region_name="nramp" /note="NRAMP (natural resistance-associated macrophage protein) metal ion transporters; TIGR01197" /db_xref="CDD:162246" CDS 1..575 /gene="SMF1" /locus_tag="YOL122C" /gene_synonym="SBS1" /coded_by="NM_001183376.1:1..1728" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8643535]" /experiment="EXISTENCE:direct assay:GO:0015295 solute:proton symporter activity [PMID:10574989]" /experiment="EXISTENCE:direct assay:GO:0022890 inorganic cation transmembrane transporter activity [PMID:10574989]" /experiment="EXISTENCE:genetic interaction:GO:0006825 copper ion transport [PMID:9115231]" /experiment="EXISTENCE:genetic interaction:GO:0006826 iron ion transport [PMID:10930410]" /experiment="EXISTENCE:genetic interaction:GO:0006878 intracellular copper ion homeostasis [PMID:9115231]" /experiment="EXISTENCE:genetic interaction:GO:0015691 cadmium ion transport [PMID:9115231]" /experiment="EXISTENCE:mutant phenotype:GO:0006828 manganese ion transport [PMID:8643535]" /experiment="EXISTENCE:mutant phenotype:GO:0030026 intracellular manganese ion homeostasis [PMID:8643535]" /note="Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins" /db_xref="GeneID:854027" /db_xref="SGD:S000005482" ORIGIN 1 mvnvgpshaa vavdaseark rniseevfel rdkkdstvvi egeapvrtft ssssnhered 61 tyvskrqvmr difakylkfi gpglmvsvay idpgnystav dagasnqfsl lciillsnfi 121 aiflqclcik lgsvtgldls racreylprw lnwtlyffae caviatdiae vigtaialni 181 likvplpagv aitvvdvfli mftykpgass irfirifecf vavlvvgvci cfaielayip 241 kstsvkqvfr gfvpsaqmfd hngiytaisi lgatvmphsl flgsalvqpr lldydvkhgn 301 ytvseeqdkv kksksteeim eekyfnyrpt naaikycmky smvelsitlf tlalfvncai 361 lvvagstlyn speadgadlf tihellsrnl apaagtifml alllsgqsag vvctmsgqiv 421 seghinwklq pwqrrlatrc isiipclvis icigrealsk alnasqvvls ivlpflvapl 481 ifftckksim kteitvdhte edshnhqnnn drsagsvieq dgssgmeien gkdvkivyma 541 nnwiitviai ivwlflslln vyaivqlgms hgdis // LOCUS NP_014520 144 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS19 RPS19A [Saccharomyces cerevisiae S288C]. ACCESSION NP_014520 VERSION NP_014520.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183375.1 REFERENCE 1 (residues 1 to 144) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 144) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 144) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 144) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10663. Method: conceptual translation. FEATURES Location/Qualifiers source 1..144 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..144 /product="40S ribosomal protein eS19 RPS19A" /calculated_mol_wt="15786" Region 5..142 /region_name="Ribosomal_S19e" /note="Ribosomal protein S19e; pfam01090" /db_xref="CDD:460058" CDS 1..144 /gene="RPS19A" /locus_tag="YOL121C" /coded_by="NM_001183375.1:1..435" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16159874|PMID:16246728]" /experiment="EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:16159874]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:16159874]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:16159874]" /note="Protein component of the small (40S) ribosomal subunit; required for assembly and maturation of pre-40 S particles; homologous to mammalian ribosomal protein S19, no bacterial homolog; mutations in human RPS19 are associated with Diamond Blackfan anemia; RPS19A has a paralog, RPS19B, that arose from the whole genome duplication" /db_xref="GeneID:854028" /db_xref="SGD:S000005481" ORIGIN 1 mpgvsvrdva aqdfinayas flqrqgklev pgyvdivkts sgnemppqda egwfykraas 61 varhiymrkq vgvgklnkly ggaksrgvrp ykhidasgsi nrkvlqalek igiveispkg 121 grrisengqr dldriaaqtl eede // LOCUS NP_014521 186 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL18 RPL18A [Saccharomyces cerevisiae S288C]. ACCESSION NP_014521 VERSION NP_014521.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183374.1 REFERENCE 1 (residues 1 to 186) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 186) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 186) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 186) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10664. Method: conceptual translation. FEATURES Location/Qualifiers source 1..186 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..186 /product="60S ribosomal protein eL18 RPL18A" /calculated_mol_wt="20432" Region 2..186 /region_name="Ribosomal_L18" /note="Ribosomal protein 60S L18 and 50S L18e; pfam17135" /db_xref="CDD:465358" CDS 1..186 /gene="RPL18A" /locus_tag="YOL120C" /gene_synonym="RP28A" /coded_by="NM_001183374.1:1..561" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication" /db_xref="GeneID:854029" /db_xref="SGD:S000005480" ORIGIN 1 mgidhtskqh krsghrtapk sdnvylkllv klytflarrt dapfnkvvlk alflskinrp 61 pvsvsriara lkqegaankt vvvvgtvtdd arifefpktt vaalrftaga rakivkagge 121 citldqlavr apkgqntlil rgprnsreav rhfgmgphkg kaprilstgr kferargrrr 181 skgfkv // LOCUS NP_014522 501 aa linear PLN 30-JUN-2025 DEFINITION Mch4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014522 VERSION NP_014522.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183373.1 REFERENCE 1 (residues 1 to 501) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 501) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 501) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 501) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10665. Method: conceptual translation. FEATURES Location/Qualifiers source 1..501 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..501 /product="Mch4p" /calculated_mol_wt="54576" Region 96..490 /region_name="MFS_MCT_SLC16" /note="Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; cd17352" /db_xref="CDD:340910" Site order(107..108,111..112,115,152,203..204,206..208,211,230, 233..234,237,318,321..322,325..327,330,357,361,413..414, 418,422,438,441..442,445..446,449) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340910" CDS 1..501 /gene="MCH4" /locus_tag="YOL119C" /coded_by="NM_001183373.1:1..1506" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11536335]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Protein with similarity to mammalian monocarboxylate permeases; monocarboxylate permeases are involved in transport of monocarboxylic acids across the plasma membrane but mutant is not deficient in monocarboxylate transport" /db_xref="GeneID:854030" /db_xref="SGD:S000005479" ORIGIN 1 mlnipiians krflfskdhe aqstrdhdve letregpssg ynpnfnaada ilkknsdqvd 61 ldvnkltnvt srvlntpeas liydddrefp dgglkawlvv fgafmglvpv fglinslgai 121 esyiskhqla nissstiswi fslylaisfl scilsggyfd rngsiglmct gtviyagglf 181 alancksvwq filafsvcsg lgtgilmtpl igtvatwflk rrgiatsist mggsiggivf 241 pimlrklyke vgfqwairil sficltclic asvlarertk pvvqpfkska evakwyissv 301 fnwryflegk flfvaigasf aessltscat ylasysmtrg ntenvaytmi tasnavgilg 361 ryipgyfadk figrfnveii tismaalfnf vmwlpfggnt kvlwayvclw gfstgsilsl 421 tpvcigqisk ttdfgkryat vyllqalvti pvlpiggtli gkgtvanynh fiifnsalma 481 agaacyiisr hicvgaklck f // LOCUS NP_001335812 102 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL118C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335812 VERSION NP_001335812.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348874.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80332. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..102 /product="uncharacterized protein" /calculated_mol_wt="12139" CDS 1..102 /locus_tag="YOL118C" /coded_by="NM_001348874.1:1..309" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:854031" /db_xref="SGD:S000005478" ORIGIN 1 msfrkkklkp pagsqfiind simsyidrtk tlirmigckn qyikarmkdk tffytkqfrt 61 aknkfffhly hweathinvd hyictchpif wgsigqklrr sa // LOCUS NP_014524 645 aa linear PLN 30-JUN-2025 DEFINITION Rri2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014524 VERSION NP_014524.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183371.1 REFERENCE 1 (residues 1 to 645) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 645) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 645) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 645) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 645) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10666. Method: conceptual translation. FEATURES Location/Qualifiers source 1..645 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..645 /product="Rri2p" /calculated_mol_wt="76258" CDS 1..645 /gene="RRI2" /locus_tag="YOL117W" /gene_synonym="CSN10" /coded_by="NM_001183371.1:1..1938" /experiment="EXISTENCE:direct assay:GO:0008180 COP9 signalosome [PMID:12446563]" /experiment="EXISTENCE:genetic interaction:GO:0000747 conjugation with cellular fusion [PMID:12446563]" /experiment="EXISTENCE:genetic interaction:GO:0071444 cellular response to pheromone [PMID:12446563]" /experiment="EXISTENCE:mutant phenotype:GO:0000338 protein deneddylation [PMID:12446563|PMID:12186635]" /note="Subunit of the COP9 signalosome (CSN) complex; this complex cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response" /db_xref="GeneID:854032" /db_xref="SGD:S000005477" ORIGIN 1 msdednnydd fmlsddegme siemeeetdd edkqnieine dnsqddqdrg aarhkqheqg 61 tfekhdrved icerifeqgq alkederyke ardlflkiyy keefssdesi erlmtwkfks 121 lieilrlral qlyfqkngaq dlvlqiledt atmsvflqri dfqidgnife llsdtfevla 181 pkwervflfd iekvdrenmi ckidfqknfm dqfqwilrkp gkdcklqnlq riirkkifia 241 vvwyqrltmg nvftpeissq ieilvkdnec ssfeenndle svsmllqyyi leymntarin 301 nrrlfkkcid ffemlisksl tfsqesglmv ilytskivfi ldsdsendls falmryydrk 361 eelknmflyi lkhleemgkl rerditslfh kfilsgfift smileaistd kinpfgfeqv 421 kialgspivn vledvyrcfa qlelrqlnas islipelsvv lsgiiqdiyy laqtlklwrk 481 iarlyscisi sdiismlqis ddnemtrddl ltilmrsimk nrsvvyfkld ltsdlvyfgd 541 enkvmlprcs keefrlmisp kdeettekar lidfeyvndv aiynnptrir tksskeffnt 601 lrksretvkl prvsnqsned tflpsymkfs nkylelckla snnle // LOCUS NP_014525 382 aa linear PLN 30-JUN-2025 DEFINITION Msn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014525 VERSION NP_014525.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183370.1 REFERENCE 1 (residues 1 to 382) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 382) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 382) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 382) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10667. Method: conceptual translation. FEATURES Location/Qualifiers source 1..382 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..382 /product="Msn1p" /calculated_mol_wt="42929" Region 278..356 /region_name="GCR1_C" /note="Transcriptional activator of glycolytic enzymes; pfam12550" /db_xref="CDD:432628" CDS 1..382 /gene="MSN1" /locus_tag="YOL116W" /gene_synonym="FUP1; HRB382; MSS10; PHD2" /coded_by="NM_001183370.1:1..1149" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:2263457]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:20802496]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10409737]" /experiment="EXISTENCE:genetic interaction:GO:0071475 cellular hyperosmotic salinity response [PMID:10409737]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:10409737]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10409737|PMID:15773992|PMID:8710886|PMID:8662191|PMI D:9987114]" /experiment="EXISTENCE:mutant phenotype:GO:0071475 cellular hyperosmotic salinity response [PMID:10409737]" /experiment="EXISTENCE:mutant phenotype:GO:0097238 cellular response to methylglyoxal [PMID:15773992]" /experiment="EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:8710886]" /experiment="EXISTENCE:mutant phenotype:GO:2000222 positive regulation of pseudohyphal growth [PMID:8710886]" /experiment="EXISTENCE:mutant phenotype:GO:2000883 positive regulation of starch catabolic process [PMID:8662191|PMID:9987114]" /note="Transcriptional activator; involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:854033" /db_xref="SGD:S000005476" ORIGIN 1 masnqhigas nlneneailt nrvaelerrm smfegifhal snrldlhfkk ydvvvnsqqq 61 qineltafls tllndqqrha eilseklsgt lhgvsatsis lsqtldpqgf tdgttapgap 121 rnytsvpmnn dqtahpqneg avsnetlfed ilngnsqend ksqqqtnssn sisqennstn 181 psvdtrfnkp qnynsnlvps leeysanppn ndggqsqgly issnssqsrq spnlqkvspn 241 henavesnaq esvptfeeeq yetktglkrk rivctrpfef iksphsvmev wkeytegvng 301 qpsirkmeal yqtawrrdpa vnkrysrrkv lwkaiqtgln rgyslnyvve ilensryvnd 361 kqkvkqpigw lchsshipet lk // LOCUS NP_014526 584 aa linear PLN 30-JUN-2025 DEFINITION non-canonical poly(A) polymerase PAP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014526 VERSION NP_014526.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183369.1 REFERENCE 1 (residues 1 to 584) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 584) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 584) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 584) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 584) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10668. Method: conceptual translation. FEATURES Location/Qualifiers source 1..584 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..584 /product="non-canonical poly(A) polymerase PAP2" /EC_number="2.7.7.19" /calculated_mol_wt="65900" Region 116..584 /region_name="TRF4" /note="DNA polymerase sigma [Replication, recombination and repair]; COG5260" /db_xref="CDD:227585" CDS 1..584 /gene="PAP2" /locus_tag="YOL115W" /gene_synonym="TRF4" /coded_by="NM_001183369.1:1..1755" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10066793|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16541108]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0031499 TRAMP complex [PMID:15935758|PMID:15828860|PMID:15935759]" /experiment="EXISTENCE:direct assay:GO:0034458 3'-5' RNA helicase activity [PMID:22532666]" /experiment="EXISTENCE:direct assay:GO:0051575 5'-deoxyribose-5-phosphate lyase activity [PMID:17983848]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15935758|PMID:15828860|PMID:17643380]" /experiment="EXISTENCE:direct assay:GO:1990817 poly(A) RNA polymerase activity [PMID:16260630|PMID:15935759|PMID:12062100|PMID:15935758|P MID:16374505]" /experiment="EXISTENCE:genetic interaction:GO:0006284 base-excision repair [PMID:17983848]" /experiment="EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491]" /experiment="EXISTENCE:genetic interaction:GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing [PMID:17410208]" /experiment="EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16541108|PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:16373491|PMID:15935758]" /experiment="EXISTENCE:genetic interaction:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15145828]" /experiment="EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:15935759]" /experiment="EXISTENCE:genetic interaction:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:16373491]" /experiment="EXISTENCE:genetic interaction:GO:0071044 histone mRNA catabolic process [PMID:17179095]" /experiment="EXISTENCE:genetic interaction:GO:0071051 poly(A)-dependent snoRNA 3'-end processing [PMID:18951092|PMID:16373491]" /experiment="EXISTENCE:genetic interaction:GO:1990817 poly(A) RNA polymerase activity [PMID:16374505]" /experiment="EXISTENCE:mutant phenotype:GO:0006284 base-excision repair [PMID:17983848]" /experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:22319136]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:25210768]" /experiment="EXISTENCE:mutant phenotype:GO:0045910 negative regulation of DNA recombination [PMID:23762389]" /experiment="EXISTENCE:mutant phenotype:GO:0051575 5'-deoxyribose-5-phosphate lyase activity [PMID:17983848]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16431988|PMID:18007593|PMID:15935758]" /experiment="EXISTENCE:mutant phenotype:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:15935758]" /experiment="EXISTENCE:mutant phenotype:GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process [PMID:16431988|PMID:15935758]" /experiment="EXISTENCE:mutant phenotype:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:16431988|PMID:18456844]" /experiment="EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:18007593|PMID:15935759|PMID:16973436|PMID:18591258]" /experiment="EXISTENCE:mutant phenotype:GO:0071040 nuclear polyadenylation-dependent antisense transcript catabolic process [PMID:18022365]" /experiment="EXISTENCE:mutant phenotype:GO:0071047 polyadenylation-dependent mRNA catabolic process [PMID:19369424]" /experiment="EXISTENCE:mutant phenotype:GO:1990817 poly(A) RNA polymerase activity [PMID:15828860|PMID:16260630|PMID:15935759]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27076633]" /note="Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia" /db_xref="GeneID:854034" /db_xref="SGD:S000005475" ORIGIN 1 mgaksvtass skkiknrhng kvkkskkikk vrkpqksisl ndeneveilp srneqetnkl 61 pkdhvtadgi lvlehksddd egfdvydghf dnptdipstt eesktpslav hgdekdlann 121 ddfislsass edeqaeqeee rekqeleikk ekqkeilntd ypwilnhdhs kqkeisdwlt 181 feikdfvayi spsreeieir nqtistirea vkqlwpdadl hvfgsystdl ylpgsdidcv 241 vtselggkes rnnlyslash lkkknlatev evvakarvpi ikfvephsgi hidvsfertn 301 gieaaklire wlddtpglre lvlivkqflh arrlnnvhtg glggfsiicl vfsflhmhpr 361 iitneidpkd nlgvllieff elygknfgyd dvalgssdgy pvyfpkstws aiqpiknpfs 421 laiqdpgdes nnisrgsfni rdikkafaga fdlltnrcfe lhsatfkdrl gksilgnvik 481 yrgkardfkd erglvlnkai ienenyhkkr sriihdedfa edtvtstata tttdddyeit 541 nppakkakie ekpesepakr nsgetyitvs sedddedgyn pytl // LOCUS NP_014527 202 aa linear PLN 30-JUN-2025 DEFINITION Pth4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014527 VERSION NP_014527.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183368.1 REFERENCE 1 (residues 1 to 202) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 202) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 202) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 202) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 202) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10669. Method: conceptual translation. FEATURES Location/Qualifiers source 1..202 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..202 /product="Pth4p" /calculated_mol_wt="23059" Region 71..198 /region_name="PrfB" /note="Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; COG1186" /db_xref="CDD:440799" CDS 1..202 /gene="PTH4" /locus_tag="YOL114C" /coded_by="NM_001183368.1:1..609" /experiment="EXISTENCE:direct assay:GO:0004045 peptidyl-tRNA hydrolase activity [PMID:33686140]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:25683707]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:33686140]" /note="Stalled-ribosome rescue factor srRF1; similar to human peptidyl-tRNA hydrolase ICT1; associates with mitochondrial large subunit; not an essential gene" /db_xref="GeneID:854035" /db_xref="SGD:S000005474" ORIGIN 1 mttlmgkfkl tgrsplfvlq pmlhckkqqf veeavrlisn kkigkksdfv qarnwvgaln 61 vtglplnqfi lrydrasgpg gqnvnkvnsk ctltlsglsn cawipqevrn ilssgrfryy 121 akgsdsiviq sdetrsretn klkcfeklvq eirqtcqfpn dttaetskkw nkikekanke 181 rlldkkvhsd kkknrskikf ny // LOCUS NP_014528 655 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase SKM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014528 VERSION NP_014528.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183367.1 REFERENCE 1 (residues 1 to 655) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 655) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 655) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 655) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10670. Method: conceptual translation. FEATURES Location/Qualifiers source 1..655 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..655 /product="putative serine/threonine protein kinase SKM1" /EC_number="2.7.11.1" /calculated_mol_wt="75200" Region 4..113 /region_name="PH_Cla4_Ste20" /note="Pleckstrin homology (PH) domain; cd13279" /db_xref="CDD:270097" Region 122..180 /region_name="PBD" /note="P21-Rho-binding domain; pfam00786" /db_xref="CDD:395634" Site order(123,126,129,131,134,151,155) /site_type="other" /note="GTPase interaction site [polypeptide binding]" /db_xref="CDD:238526" Region 359..640 /region_name="STKc_PAK" /note="Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; cd06614" /db_xref="CDD:270789" Site order(366..370,374,404,406,435,452..456,458..459,462,507, 509..512,514,524..525,528,541..545,547,574,583..585) /site_type="active" /db_xref="CDD:270789" Site order(366..370,374,404,406,435,452..456,458..459,462, 511..512,514,524..525) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270789" Site order(369..370,507,509..511,528,541..545,547,574,583..585) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270789" Site order(524..535,540..547) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270789" CDS 1..655 /gene="SKM1" /locus_tag="YOL113W" /coded_by="NM_001183367.1:1..1968" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19793923]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15023338]" /experiment="EXISTENCE:genetic interaction:GO:0010629 negative regulation of gene expression [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:9044278]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0010629 negative regulation of gene expression [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:19793923]" /experiment="EXISTENCE:mutant phenotype:GO:2000910 negative regulation of sterol import [PMID:19793923]" /note="Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication" /db_xref="GeneID:854036" /db_xref="SGD:S000005473" ORIGIN 1 mkgvkkegwi sykvdglfsf lwqkrylvln dsylafyksd kcneepvlsv pltsitnvsr 61 iqlkqncfei lratdqkeni spinsyfyes nskrsifist rterdlhgwl daifakcpll 121 sgvssptnft hkvhvgfdpk vgnfvgvpds wakllqtsei tyddwnrnsk avikalqfye 181 dyngldtmqf ndhlntsldl kplksptryi inkrtnsikr svsrtlrkgk tdsilpvyqs 241 elkpfprpsd ddykftnied nkvreegrvh vskestadsq tkqlgkkeqk viqshlrrhd 301 nnstfrphrl apsapatknh dsktkwhked llelknndds neiimkmktv aidvnprpyf 361 qlvekagqga sgavylskri klpqendprf lkshchrvvg ervaikqirl seqpkkqlim 421 nellvmndsr qenivnflea yiiddeelwv imeymeggcl tdildavars ntgehsspln 481 enqmayivke tcqglkflhn kkiihrdiks dnillnsqgl vkitdfgfcv eltekrskra 541 tmvgtpywma peivnqkgyd ekvdvwslgi mliemiegep pylnedplka lylianngsp 601 klrhpesvsk qtkqfldacl qvnvesrasv rklltfefls macspeqlkv slkwh // LOCUS NP_014529 492 aa linear PLN 30-JUN-2025 DEFINITION Rab GTPase-activating protein MSB4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014529 VERSION NP_014529.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183366.1 REFERENCE 1 (residues 1 to 492) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 492) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 492) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 492) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10671. Method: conceptual translation. FEATURES Location/Qualifiers source 1..492 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..492 /product="Rab GTPase-activating protein MSB4" /calculated_mol_wt="56962" Region <53..461 /region_name="COG5210" /note="GTPase-activating protein [General function prediction only]" /db_xref="CDD:227535" CDS 1..492 /gene="MSB4" /locus_tag="YOL112W" /coded_by="NM_001183366.1:1..1479" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:10679030]" /experiment="EXISTENCE:direct assay:GO:0000133 polarisome [PMID:16166638]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:10937877]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:10679030]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:35134079]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:12913108]" /experiment="EXISTENCE:genetic interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:16166638]" /experiment="EXISTENCE:physical interaction:GO:0070649 formin-nucleated actin cable assembly [PMID:16166638|PMID:12913108]" /note="GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null mutant" /db_xref="GeneID:854037" /db_xref="SGD:S000005472" ORIGIN 1 mimsstmste aalvpnesvf dtvssfnedd anysvldlyd dddegddsst verkeilttr 61 elekakafts limadpenfd rygfskkgyf isqeeydkww teynryterr kkkwenfllk 121 nkielhndnp lvypartdel skfvrkgipa ewrgnawwyf aggqrqldan vgvydrlksd 181 cregavsgkd meaierdlyr tfpdnihfhk esfqngepai irslrrvlma fsvydktigy 241 cqsmnflvgl lllfmeeeka fwmlviitgk ylpgvyesdl eganvdqgvl vlcikeylpe 301 iwshiessym ngngstdqis gpasgeeylc rlptltlcta swfmscfvgv vpiettlriw 361 dclfyeeshf lfkvalgilk lseseflesk sqklfrqyss ytfggsndsd stfkrlknki 421 ktqeeadmei lqviqnfpkr llnpndifek vlmkkkvaln gitqekidrg reyvamarnr 481 qrassrpker rk // LOCUS NP_014530 212 aa linear PLN 30-JUN-2025 DEFINITION Mdy2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014530 VERSION NP_014530.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183365.1 REFERENCE 1 (residues 1 to 212) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 212) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 212) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 212) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 212) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10672. Method: conceptual translation. FEATURES Location/Qualifiers source 1..212 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..212 /product="Mdy2p" /calculated_mol_wt="23601" Region 8..59 /region_name="Get5_bdg" /note="Binding domain to Get4 on Get5, Golgi to ER traffic protein; pfam16843" /db_xref="CDD:407090" Region 74..148 /region_name="Ubl_Rad23" /note="ubiquitin-like (Ubl) domain found in the Rad23 protein family; cd01805" /db_xref="CDD:340503" Site order(79,81,118,120,123..125,145,147..148) /site_type="other" /note="T1 interaction site [polypeptide binding]" /db_xref="CDD:340503" Site order(79..81,118,120..125,142..145,147) /site_type="other" /note="UIM interaction site [polypeptide binding]" /db_xref="CDD:340503" Site order(79,81,118,120..125,127,145,147) /site_type="other" /note="Sgt2 interaction site [polypeptide binding]" /db_xref="CDD:340503" Site order(79,84,102,104,124,139) /site_type="other" /note="key conserved lysines" /db_xref="CDD:340503" Site order(81,122..125,127,147) /site_type="other" /note="Ufd2P interaction site [polypeptide binding]" /db_xref="CDD:340503" Region 174..212 /region_name="Get5_C" /note="Get5 C-terminal domain; pfam18514" /db_xref="CDD:408303" CDS 1..212 /gene="MDY2" /locus_tag="YOL111C" /gene_synonym="GET5; TMA24" /coded_by="NM_001183365.1:1..639" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16390866|PMID:23285234]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:20850366]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23285234|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:17441508]" /experiment="EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]" /experiment="EXISTENCE:genetic interaction:GO:0045048 protein insertion into ER membrane [PMID:19325107]" /experiment="EXISTENCE:mutant phenotype:GO:0000753 cell morphogenesis involved in conjugation with cellular fusion [PMID:16390866]" /note="Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes" /db_xref="GeneID:854038" /db_xref="SGD:S000005471" ORIGIN 1 mstsasgpeh efvskfltla tltepklpks ytkplkdvtn lgvplptlky kykqnrakkl 61 klhqdqqgqd naavhltlkk iqapkfsieh dfspsdtilq ikqhliseek ashiseikll 121 lkgkvlhdnl flsdlkvtpa nstitvmikp nptiskepea ekstnspapa ppqeltvpwd 181 dieallknnf endqaavrqv merlqkgwsl ak // LOCUS NP_014531 237 aa linear PLN 30-JUN-2025 DEFINITION Shr5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014531 VERSION NP_014531.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183364.1 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10673. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..237 /product="Shr5p" /calculated_mol_wt="26411" Region 116..230 /region_name="Erf4" /note="Golgin subfamily A member 7/ERF4 family; pfam10256" /db_xref="CDD:463029" CDS 1..237 /gene="SHR5" /locus_tag="YOL110W" /gene_synonym="ERF4" /coded_by="NM_001183364.1:1..714" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016409 palmitoyltransferase activity [PMID:12193598]" /experiment="EXISTENCE:direct assay:GO:0018345 protein palmitoylation [PMID:12193598]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:7532279]" /experiment="EXISTENCE:mutant phenotype:GO:0018345 protein palmitoylation [PMID:16751107]" /experiment="EXISTENCE:physical interaction:GO:0031211 endoplasmic reticulum palmitoyltransferase complex [PMID:12193598]" /note="Palmitoyltransferase subunit; this complex adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization; Palmitoyltransferase is composed of Shr5p and Erf2" /db_xref="GeneID:854039" /db_xref="SGD:S000005470" ORIGIN 1 mcdshqkeed nantseralf fnyhefsysf yedlgsedak ptehdedhkl cithfpnvya 61 argsaefqvt rvvrvprrfd esrssletpq fstqlpgsep aaivgddgts fvrcgrydig 121 dhvfgcssvs plseylsaae laevvhrvng fllreegevf gwrnlsglll dmltgglwsw 181 vlgpllsrpv fqeslaleqy vaqlnspggl lhergvrlvl prrsgclsld fvvprpk // LOCUS NP_014532 113 aa linear PLN 30-JUN-2025 DEFINITION Zeo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014532 VERSION NP_014532.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183363.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10674. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..113 /product="Zeo1p" /calculated_mol_wt="12458" Region <12..97 /region_name="PRK00409" /note="recombination and DNA strand exchange inhibitor protein; Reviewed" /db_xref="CDD:234750" CDS 1..113 /gene="ZEO1" /locus_tag="YOL109W" /coded_by="NM_001183363.1:1..342" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12949174|PMID:16622836]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:12949174]" /experiment="EXISTENCE:mutant phenotype:GO:1903138 negative regulation of cell integrity MAPK cascade [PMID:12949174]" /note="Peripheral membrane protein of the plasma membrane; interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria" /db_xref="GeneID:854040" /db_xref="SGD:S000005469" ORIGIN 1 mseiqnkaet aaqdvqqkle etkeslqnkg qevkeqaeas idnlkneatp eaeqvkkeeq 61 niadgveqkk teaankveet kkqasaavse kketkkeggf lkklnrkias ifn // LOCUS NP_014533 151 aa linear PLN 30-JUN-2025 DEFINITION Ino4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014533 VERSION NP_014533.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183362.1 REFERENCE 1 (residues 1 to 151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 151) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10675. Method: conceptual translation. FEATURES Location/Qualifiers source 1..151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..151 /product="Ino4p" /calculated_mol_wt="17247" Region 45..115 /region_name="bHLH_scINO4_like" /note="basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar proteins; cd11403" /db_xref="CDD:381409" Site order(47,49..51,53..55,57..58,62,82..83) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:381409" Site order(61,64..65,67..68,71..73,84,87..88,91,93..95,97..98, 100..101,104,107..108,111..112,114..115) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:381409" CDS 1..151 /gene="INO4" /locus_tag="YOL108C" /coded_by="NM_001183362.1:1..456" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:8195172]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8195172]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15455074]" /experiment="EXISTENCE:direct assay:GO:0090575 RNA polymerase II transcription regulator complex [PMID:8195172]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8195172]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:2834106]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8195172|PMID:1461729]" /experiment="EXISTENCE:physical interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8195172]" /experiment="EXISTENCE:physical interaction:GO:0090575 RNA polymerase II transcription regulator complex [PMID:8195172]" /note="Transcription factor involved in phospholipid synthesis; required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain" /db_xref="GeneID:854042" /db_xref="SGD:S000005468" ORIGIN 1 mtndikeiqt iqpglseike ikgelanvkk rkrrskkink ltdgqirinh vssekkrrel 61 eraifdelva vvpdlqpqes rseliiylks lsylswlyer neklrkqiia kheaktgsss 121 ssdpvqeqng nirdlvpkel iwelgdgqsg q // LOCUS NP_014534 342 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL107W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014534 VERSION NP_014534.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183361.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10676. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..342 /product="uncharacterized protein" /calculated_mol_wt="39611" Region 72..170 /region_name="DUF1751" /note="Eukaryotic integral membrane protein (DUF1751); pfam08551" /db_xref="CDD:369945" CDS 1..342 /locus_tag="YOL107W" /coded_by="NM_001183361.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030137 COPI-coated vesicle [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein" /db_xref="GeneID:854043" /db_xref="SGD:S000005467" ORIGIN 1 mqyssrflel nipdsflnin kipdatkfit vtyicltatl fcirrslynk lvledpnldy 61 nlitspllqm vpsqiwrypt slvlsnfidt kawkvvvnll nliiggsfie rnwnsskemf 121 kfiivlgslt nvliimltll vsffsnkvrl dipldgnyti ligfpiiyrq llpettiihl 181 ktpqflaknf rfkllpifvm ftmtvtqiiw fhhfaqlfsi wvtffaswsy lrffqklapl 241 ncpslpttns qggqeilvgd asdtfqliyf fpdlikpilr pifnfiynvv vvkfkvikpf 301 hdididignt iaesrgakki mtveerrrql alqvleermv np // LOCUS NP_014536 556 aa linear PLN 30-JUN-2025 DEFINITION Wsc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014536 VERSION NP_014536.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183359.1 REFERENCE 1 (residues 1 to 556) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 556) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 556) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 556) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10677. Method: conceptual translation. FEATURES Location/Qualifiers source 1..556 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..556 /product="Wsc3p" /calculated_mol_wt="58099" Region 39..132 /region_name="WSC" /note="present in yeast cell wall integrity and stress response component proteins; smart00321" /db_xref="CDD:214616" CDS 1..556 /gene="WSC3" /locus_tag="YOL105C" /coded_by="NM_001183359.1:1..1671" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27337501]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20385774]" /experiment="EXISTENCE:mutant phenotype:GO:0004888 transmembrane signaling receptor activity [PMID:10430578]" /experiment="EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:10348843]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10348843]" /note="Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication" /db_xref="GeneID:854046" /db_xref="SGD:S000005465" ORIGIN 1 mervwfaklt nkgtikigyi sfillsllcq sliglvnadf nyegcysaad iqsaglslkn 61 syiyqsvsyc qnqcpesavv alfngsdcyc gnsvsfltsl tkstdsncgt kcsgwpyqmc 121 ggssymnvyv naetfvssve sssskegsst sympsttssl ssaqissttr rtstdmksse 181 miattvstts ttssstsstt ssttssttss ttssttssst ssttssttss ttssttsstt 241 ssttssttss ttssttsifs vtsssssitl sssehttvds rtsspsstlv pvssssstls 301 tpkvtsmtps tsstipivts velvtsvvtk aivstsdqhq etifvtrtsv verssevata 361 taaasnnrsn stskqrlsgg aiagivigvv fgvifiilil lfliwrrrks hdqldleetk 421 hyqpysfgde danpigppps sgttnwmrhs rgntagsigt snmygfsmsn ganysspssn 481 tsgsiinnla glqdatvqkq nlpstvfeea ntlnsanerf sanslpdmmm sgplqvvnpd 541 npdnpelsst vshnra // LOCUS NP_014537 352 aa linear PLN 30-JUN-2025 DEFINITION Ndj1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014537 VERSION NP_014537.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183358.1 REFERENCE 1 (residues 1 to 352) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 352) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 352) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 352) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 352) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10678. Method: conceptual translation. FEATURES Location/Qualifiers source 1..352 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..352 /product="Ndj1p" /calculated_mol_wt="40725" CDS 1..352 /gene="NDJ1" /locus_tag="YOL104C" /gene_synonym="TAM1" /coded_by="NM_001183358.1:1..1059" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:9157883|PMID:9242487|PMID:25897084]" /experiment="EXISTENCE:direct assay:GO:0007129 homologous chromosome pairing at meiosis [PMID:9157883]" /experiment="EXISTENCE:direct assay:GO:0035974 meiotic spindle pole body [PMID:25897084]" /experiment="EXISTENCE:direct assay:GO:0045141 meiotic telomere clustering [PMID:12734403]" /experiment="EXISTENCE:genetic interaction:GO:0007129 homologous chromosome pairing at meiosis [PMID:17495028]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:9157883|PMID:17495028]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:16648465]" /experiment="EXISTENCE:mutant phenotype:GO:0010520 regulation of reciprocal meiotic recombination [PMID:18818742|PMID:18818741]" /experiment="EXISTENCE:mutant phenotype:GO:0045141 meiotic telomere clustering [PMID:11018056]" /experiment="EXISTENCE:mutant phenotype:GO:0070197 meiotic attachment of telomere to nuclear envelope [PMID:18818742|PMID:18818741]" /experiment="EXISTENCE:mutant phenotype:GO:2000711 positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric [PMID:25897084]" /note="Protein that regulates meiotic SPB cohesion and telomere clustering; localizes to both spindle pole bodies (SPBs) and telomeres; required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement" /db_xref="GeneID:854047" /db_xref="SGD:S000005464" ORIGIN 1 mskdnrlasi llqpvasssg nctefhdskl htlqeelnfl plegvasnvc ppmfrghkny 61 vfvlyclnqv dlvtnlqdst kryyplqifk dcqlsslvqk dfshyfqlsr qkegedrnds 121 dttlvnvvns gvsrhrsqll kmciiprics fdksnsktyk liqeyvnrfe tvltkfgpek 181 dftkvyanws kliesfneli lhdllvkwqq wseltqpnat vhqnipnvlr elvikltqry 241 ftfqpsyscs idefttilln knalslldvf rkprkyklnf glwldcqngi liftngivqm 301 adeitservk sfvrpahllv ledhsndeav kklmfftfsa ilqcftdeil nc // LOCUS NP_058182 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058182 VERSION NP_058182.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184383.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10680. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..440 /product="gag protein" /calculated_mol_wt="48874" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YOL103W-A" /coded_by="NM_001184383.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:854048" /db_xref="SGD:S000007349" ORIGIN 1 mesqqlsnyp qishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniinrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_058181 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058181 VERSION NP_058181.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184384.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10679. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198484" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YOL103W-B" /coded_by="join(NM_001184384.2:1..1305, NM_001184384.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:854049" /db_xref="SGD:S000007350" ORIGIN 1 mesqqlsnyp qishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniinrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyqsf iasneiqqsd dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd eyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_014538 609 aa linear PLN 30-JUN-2025 DEFINITION myo-inositol transporter ITR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014538 VERSION NP_014538.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183357.1 REFERENCE 1 (residues 1 to 609) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 609) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 609) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 609) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10681. On Oct 2, 2003 this sequence version replaced NP_014538.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..609 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..609 /product="myo-inositol transporter ITR2" /calculated_mol_wt="66579" Region 115..556 /region_name="MFS_HMIT_like" /note="H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; cd17360" /db_xref="CDD:340918" Site order(123,127,244,247..248,251,371..372,376..377,380..381, 406,481..482,485..486,490,512..513,516) /site_type="other" /note="chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340918" CDS 1..609 /gene="ITR2" /locus_tag="YOL103W" /gene_synonym="HRB612" /coded_by="NM_001183357.1:1..1830" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16233524]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005365 myo-inositol transmembrane transporter activity [PMID:2040626]" /experiment="EXISTENCE:mutant phenotype:GO:0015798 myo-inositol transport [PMID:2040626]" /note="Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication" /db_xref="GeneID:854050" /db_xref="SGD:S000005463" ORIGIN 1 mknstaassr wtksrlshff psytnssgmg aastdqsstq geelhhrkhc eedndgqkpk 61 kspvststmq iksrqdeded dgrivikpvn deddtsviit fnqsispfii tltfvasisg 121 fmfgydtgyi ssalisinrd ldnkvltyge kelitaatsl galitsvgag taadvfgrrp 181 clmfsnlmfl igailqitah kfwqmaagrl imgfgvgigs lisplfisei apkmirgrlt 241 vinslwltgg qliaygcgag lnhvkngwri lvglsliptv lqfsffcflp dtpryyvmkg 301 dlkrakmvlk rsyvntedei idqkveelss lnqsipgknp itkfwnmvke lhtvpsnfra 361 liigcglqai qqftgwnslm yfsgtifetv gfknssavsi ivsgtnfvft liaffcidki 421 grryilligl pgmtvalvic aiafhflgik fngadavvas dgfsswgivi ivfiivyaaf 481 yalgigtvpw qqselfpqnv rgvgtsyata tnwagslvia stfltmlqni tptgtfsffa 541 gvaclstifc yfcypelsgl eleevqtilk dgfnikaska lakkrkqqva egaahhklkf 601 eptqeives // LOCUS NP_014539 230 aa linear PLN 30-JUN-2025 DEFINITION tRNA 2'-phosphotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014539 VERSION NP_014539.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183356.1 REFERENCE 1 (residues 1 to 230) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 230) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 230) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 230) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10682. Method: conceptual translation. FEATURES Location/Qualifiers source 1..230 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..230 /product="tRNA 2'-phosphotransferase" /EC_number="2.7.1.160" /calculated_mol_wt="26065" Region 14..190 /region_name="PTS_2-RNA" /note="RNA 2'-phosphotransferase, Tpt1 / KptA family; pfam01885" /db_xref="CDD:460371" CDS 1..230 /gene="TPT1" /locus_tag="YOL102C" /coded_by="NM_001183356.1:1..693" /experiment="EXISTENCE:direct assay:GO:0000215 tRNA 2'-phosphotransferase activity [PMID:9148937]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22391451]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22391451]" /experiment="EXISTENCE:direct assay:GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation [PMID:9148937]" /note="tRNA 2'-phosphotransferase; catalyzes the final step in tRNA splicing, transferring the 2'-PO(4) from the splice junction to NAD(+), forming ADP-ribose 1''-2''cyclic phosphate and nicotinamide; ADP-ribosyltransferase that ADP-ribosylates 5'-phosphorylated ssDNA and ssRNAs; human and mouse orthologs complement the inviability of the yeast null mutant" /db_xref="GeneID:854051" /db_xref="SGD:S000005462" ORIGIN 1 mrqvlqkdkr dvqlskalsy llrhtavkek ltidsngytp lkellshnrl kthkctvddi 61 hrivkendkq rfhiktlgad eewicatqgh siksiqpsde vlvpiteasq lpqelihgtn 121 lqsvikiies gaispmsrnh vhlspgmlha kgvisgmrss snvyifidch splffqtlkm 181 frslnnvyls ssipveliqk vvvkgnlkde ekldtlrril hernipleki // LOCUS NP_014540 312 aa linear PLN 30-JUN-2025 DEFINITION Izh4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014540 VERSION NP_014540.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183355.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10683. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..312 /product="Izh4p" /calculated_mol_wt="36477" Region 62..288 /region_name="HlyIII" /note="Haemolysin-III related; cl03831" /db_xref="CDD:470885" CDS 1..312 /gene="IZH4" /locus_tag="YOL101C" /coded_by="NM_001183355.1:1..939" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:15060275]" /note="Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress; IZH4 has a paralog, IZH1, that arose from the whole genome duplication" /db_xref="GeneID:854052" /db_xref="SGD:S000005461" ORIGIN 1 mvslttieqs pvkcetttek esndtrgtds nenaetketk kgfpfhdlak lqkqyknkss 61 rneslvaliy llgsmlsfcl lifftdfyli plfpttttmt dyivfnfyll nvfvfcmvhf 121 iyhfvknisl qqhlehwqkf sylsninlli ssqitilyyl fydyvfffki ftllmnfigl 181 vayffiltdk lisskrfnkt vffisvsvvc cslplltaii tfdglenlke rikvnaitwe 241 lvalvaasii yvtrfpeslf rrnkkeegwn hseylfhlli sgtafyhffi liqsyilmhs 301 slnqpelinf ks // LOCUS NP_014541 1081 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase PKH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014541 VERSION NP_014541.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183354.1 REFERENCE 1 (residues 1 to 1081) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1081) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1081) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1081) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10684. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1081 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1081 /product="serine/threonine protein kinase PKH2" /EC_number="2.7.11.1" /calculated_mol_wt="121530" Region 177..443 /region_name="STKc_PDK1" /note="Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; cd05581" /db_xref="CDD:270733" Site order(185..189,193,206,208,241,257..258,260,264,266,303, 305,307..308,310,320..321,324,349..354,381,387,390) /site_type="active" /db_xref="CDD:270733" Site order(185..188,191,193,206,208,227,241,257..260,263..264, 307..308,310,320..321) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270733" Site order(189,264,266,303,305,307,324,349..354,381,387,390) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270733" Site order(320..330,346..354) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270733" CDS 1..1081 /gene="PKH2" /locus_tag="YOL100W" /coded_by="NM_001183354.1:1..3246" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894|PMID:10567559]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:22918958]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12221112]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:12221112]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:37387118]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:10567559]" /experiment="EXISTENCE:genetic interaction:GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly [PMID:21163942]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:22918958]" /experiment="EXISTENCE:genetic interaction:GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening [PMID:21163942]" /experiment="EXISTENCE:mutant phenotype:GO:0000196 cell integrity MAPK cascade [PMID:10567559]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:22918958]" /note="Serine/threonine protein kinase; involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; contains a PH-like domain; redundant with Pkh1p; PKH2 has a paralog, PKH1, that arose from the whole genome duplication" /db_xref="GeneID:854053" /db_xref="SGD:S000005460" ORIGIN 1 myfdkdnsms prpllpsdeq klninlltkk ekfshldphy dakatpqrst snrnvgdlll 61 ekrtakpmiq kaltntdnfi emyhnqqrkn ldddtikevm indengktva stndgrydnd 121 ydnndindqk tldniagsph meknrnkvki ehdsssqkpi akesskaqkn iikkgikdfk 181 fgsvigdgay stvmlatsid tkkryaakvl nkeylirqkk vkyvsiekta lqklnnspsv 241 vrlfstfqde sslyflleya pngdflslmk kygsldetca ryyaaqiida idylhsngii 301 hrdikpenil ldgemkiklt dfgtakllnp tnnsvskpey dlstrsksfv gtaeyvspel 361 lndsftdyrc diwafgcilf qmiagkppfk atneyltfqk vmkvqyaftp gfpliirdlv 421 kkilvknldr rltisqikeh hffkdlnfkd gsvwsktppe ikpykinaks mqampsgsdr 481 klvkksvntl gkshlvtqrs asspsveett hstlynnnth asteseisik krptdertaq 541 ilenarkgin nrknqpgkrt psgaasaala asaaltkktm qsyptsssks srssspatts 601 rpgtykrtss teskpfaksp plsasvlssk vpmppytppm sppmtpydty qmtppyttkq 661 qdysdtaiaa pkpciskqnv knstdsplmn kqdiqwsfyl kninehvlrt ekldfvttny 721 dilekkmlkl ngslldpqlf gkprhtflsq varsggevtg frndptmtay sktedtyysk 781 niidlqlled dyrieggdls elltnrsgeg ykcnqnsspm kdddksesnn kgssvfsgki 841 kklfhptsaa etlsssdekt kyykrtivmt sfgrflvfak rrqpnpvtnl kyeleydinl 901 rqqgtkikel iiplemgtnh ivviqtpyks fllstdkktt sklftvlkki lnsntnkiek 961 ellqrnqkvi errtsssgra ipkdlptsks pspkprthsq spsiskhnsf sesinsaksn 1021 rssrifetfi nakeqnskkh aapvpltskl vnglpkrqvt vglglntgtn fknssakskr 1081 s // LOCUS NP_014543 1037 aa linear PLN 30-JUN-2025 DEFINITION Sdd3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014543 VERSION NP_014543.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183352.1 REFERENCE 1 (residues 1 to 1037) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1037) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1037) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1037) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1037) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10685. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1037 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1037 /product="Sdd3p" /calculated_mol_wt="118262" Region 29..458 /region_name="PqqL" /note="Predicted Zn-dependent peptidase, M16 family [General function prediction only]; COG0612" /db_xref="CDD:440377" Region <743..996 /region_name="PqqL" /note="Predicted Zn-dependent peptidase, M16 family [General function prediction only]; COG0612" /db_xref="CDD:440377" CDS 1..1037 /gene="SDD3" /locus_tag="YOL098C" /coded_by="NM_001183352.1:1..3114" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative metalloprotease; overproduction suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P" /db_xref="GeneID:854055" /db_xref="SGD:S000005458" ORIGIN 1 mgfkklvsfq pdyvpqyhit kyisertklq lvhinhktsp lvhgyfavpt eclndsgaph 61 tlehlifmgs ksypykglld tagnlslsnt nawtdtdqtv ytlssagwkg fskllpayld 121 hilhptltde acltevyhid penlgdkgvv fsemeaietq gwyisglekq rlmfpegsgy 181 rsetggltkn lrtltndeir qfhkslyssd nlcvivcgnv ptdelltvme ewdnklpeip 241 snipkkrpfl dnklshipqs rdkvtestve fpeldesqge llfswigvpy sdfrndlavd 301 vlldyftdsa lavftrelve iddpmanstd cctdyfmrti idlriqgvpt ekiaatktkv 361 leilkthtid lsrvrqvven tkweyllnye kngesrfssa vitdyiygne dgsslvsslk 421 dlsdfdallq wsqkdwqsll nrifvdnkpi ivtakpsalm yeqlekeksd likqreaefd 481 dekklvllkr lnnaknindr pipksllqkf eidnpsksve fvntksiatv dsykynnvsd 541 pltkkiletr pdnfplfihl nhfpsqfiel hflvnsasik dtsllpyfnm fdelfsmpmk 601 ildeesnvet mlsfeevvak lksetidaqi nqglkgscpd linfkiqcra ggysnsvqwi 661 khclfdmvfd enrvrillen ylnsivewkr ngnvmlsslt nrnlysarsl kkstdplfve 721 aklqeifaei engnfekeil prietmrkql ranfnkfhil vlgdiskidd vyepwnplik 781 clniahpvek lkippvpral dtissicrtp gekafiittp asesaymnli tsipfnldyh 841 dpeyaivsla seylecvegp fwkgirgagl aygasmlklc einswgfniy rgadiikcye 901 vgkqivqdya sgalefdeql iqgaissiin rlatiecgyf etalskyvde fclqrgnnfn 961 elylerlqnv tktdlknamq kyfvnmfdsn ksvafvschp aklesvqeff etqgftveie 1021 eleddddeid seedena // LOCUS NP_878163 61 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL097W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878163 VERSION NP_878163.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184665.1 REFERENCE 1 (residues 1 to 61) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 61) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 61) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 61) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10686. Method: conceptual translation. FEATURES Location/Qualifiers source 1..61 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..61 /product="uncharacterized protein" /calculated_mol_wt="6901" CDS 1..61 /locus_tag="YOL097W-A" /coded_by="NM_001184665.1:1..186" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466475" /db_xref="SGD:S000028854" ORIGIN 1 mqsmicsseh enltckywpv sflaswceng sgtlmqkdgs llyavknfsh ifekkifhtn 61 l // LOCUS NP_014544 432 aa linear PLN 30-JUN-2025 DEFINITION tryptophan--tRNA ligase WRS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014544 VERSION NP_014544.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183351.1 REFERENCE 1 (residues 1 to 432) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 432) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 432) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 432) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10687. Method: conceptual translation. FEATURES Location/Qualifiers source 1..432 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..432 /product="tryptophan--tRNA ligase WRS1" /EC_number="6.1.1.2" /calculated_mol_wt="49219" Region 25..409 /region_name="nt_trans" /note="nucleotidyl transferase superfamily; cl00015" /db_xref="CDD:469580" Site order(106..110,117,119..120,123,141,146,185,226,230,233, 253,255..256,258..259,262,285,295..296,298) /site_type="active" /db_xref="CDD:173903" Site 117..120 /site_type="other" /note="HIGH motif" /db_xref="CDD:173903" Site order(145,148..149,193..194,196..198,201..202,204..207, 209..210,222,224..225,228..229) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:173903" Site 295..299 /site_type="other" /note="KMSKS motif" /db_xref="CDD:173903" CDS 1..432 /gene="WRS1" /locus_tag="YOL097C" /gene_synonym="HRE342" /coded_by="NM_001183351.1:1..1299" /experiment="EXISTENCE:direct assay:GO:0004830 tryptophan-tRNA ligase activity [PMID:9046085]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /note="Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant" /db_xref="GeneID:854056" /db_xref="SGD:S000005457" ORIGIN 1 msndetvekv tqqvselkst dvkeqvvtpw dveggvdeqg raqnidydkl ikqfgtkpvn 61 eetlkrfkqv tgrephhflr kglffserdf tkildlyeqg kpfflytgrg pssdsmhlgh 121 mipfvftkwl qevfdvplvi eltddekflf khkltindvk nfarenakdi iavgfdpknt 181 fifsdlqymg gafyetvvrv srqitgstak avfgfndsdc igkfhfasiq iatafpssfp 241 nvlglpdktp clipcaidqd pyfrvcrdva dklkyskpal lhsrffpalq gsttkmsasd 301 dttaifmtdt pkqiqkkink yafsggqvsa dlhrelggnp dvdvayqyls ffkdddvflk 361 ecydkyksge llsgemkklc ietlqefvka fqerraqvde etldkfmvph klvwgekerl 421 vapkpktkqe kk // LOCUS NP_014545 312 aa linear PLN 30-JUN-2025 DEFINITION hexaprenyldihydroxybenzoate methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014545 VERSION NP_014545.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183350.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10688. On Oct 2, 2003 this sequence version replaced NP_014545.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..312 /product="hexaprenyldihydroxybenzoate methyltransferase" /EC_number="2.1.1.64" /EC_number="2.1.1.114" /calculated_mol_wt="36200" Region 40..305 /region_name="UbiG" /note="ubiquinone biosynthesis O-methyltransferase; TIGR01983" /db_xref="CDD:273910" CDS 1..312 /gene="COQ3" /locus_tag="YOL096C" /coded_by="NM_001183350.1:1..939" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:10760477]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10419476]" /experiment="EXISTENCE:direct assay:GO:0006744 ubiquinone biosynthetic process [PMID:10419476]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:1885593]" /experiment="EXISTENCE:mutant phenotype:GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity [PMID:1885593]" /experiment="EXISTENCE:mutant phenotype:GO:0061542 3-demethylubiquinol 3-O-methyltransferase activity [PMID:10419476]" /note="O-methyltransferase; catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein" /db_xref="GeneID:854057" /db_xref="SGD:S000005456" ORIGIN 1 mllrsrflkv ihvrkqlsac srfaiqtqtr ckstdasede vkhfqelapt wwdtdgsqri 61 lhkmnltrld fvqrtvrnqv kiqnpeifvp gfnykeflpe yvcdniqrem qesietnldk 121 rpevsvldvg cgggilsesl arlkwvknvq gidltrdcim vakehakkdp mlegkinyec 181 kaledvtgqf diitcmemle hvdmpseilr hcwsrlnpek gilflstinr dliswfttif 241 mgenvlkivp kgthhlskyi nskeilawfn dnysgqfrll dlkgtmylpy qgwvehdcsd 301 vgnyfmaiqr ln // LOCUS NP_014546 706 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent 3'-5' DNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014546 VERSION NP_014546.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183349.1 REFERENCE 1 (residues 1 to 706) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 706) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 706) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 706) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10689. Method: conceptual translation. FEATURES Location/Qualifiers source 1..706 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..706 /product="ATP-dependent 3'-5' DNA helicase" /EC_number="5.6.2.4" /calculated_mol_wt="80445" Region 1..630 /region_name="UvrD" /note="Superfamily I DNA or RNA helicase [Replication, recombination and repair]; COG0210" /db_xref="CDD:439980" CDS 1..706 /gene="HMI1" /locus_tag="YOL095C" /coded_by="NM_001183349.1:1..2121" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10409639]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:16358299]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:10669756]" /experiment="EXISTENCE:mutant phenotype:GO:0032042 mitochondrial DNA metabolic process [PMID:16358299]" /note="Mitochondrial inner membrane localized ATP-dependent DNA helicase; required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD" /db_xref="GeneID:854058" /db_xref="SGD:S000005455" ORIGIN 1 mdkltpsqwk vinksyepas tikviagpgs gktltllykv lhlitvenik peeilifslt 61 nkavdsiien llsifensht nkeivhqigc ytvhglanri vvenegmini ieeigwrglm 121 kllppskrtp hhfrsykele kvvkdyklnn aknnnpviek lvelmdnckv mtnddliira 181 kkyleldssd sdassftqdl rnkykvvlid efqdlypsla plitmickgk qlimfgdtnq 241 siygflgsnn eimsqldnlh pknsttvlkl fdnfrstpei islaskiinr plaekqiidd 301 tdetpselvr klpsgvspqi mtfddlaaes efiidkitql icssakfsdi ailsrtnshl 361 taiasilkky gipyqklksq pdwmddlriq flldilkvcs lasdekhnre fntgdkwqsn 421 fsilvtmsal kgigdasiqa lykacslknl siwkyltmvp nfewplglsi kkkmenytsn 481 lyemiendqv hqlddpmell ekvasitnnl nlnptyfqsl sdaqsslefk thlqemaqvm 541 kvsksnkppg isfvkwflet yfdqtmvfhq sqqalqttgp gtvklstihs akglefpivf 601 ltngsmsnfp mdtnalyvgi trarnllymc nmkherlvsk sspysrnims nnlfwtyynk 661 dlkrsvcdvk vthgynvqry nqlrknfgfy raysslrgck svfrri // LOCUS NP_014547 323 aa linear PLN 30-JUN-2025 DEFINITION replication factor C subunit 4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014547 VERSION NP_014547.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183348.1 REFERENCE 1 (residues 1 to 323) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 323) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 323) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 323) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 323) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10690. Method: conceptual translation. FEATURES Location/Qualifiers source 1..323 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..323 /product="replication factor C subunit 4" /calculated_mol_wt="36018" Region 9..323 /region_name="PLN03025" /note="replication factor C subunit; Provisional" /db_xref="CDD:178596" CDS 1..323 /gene="RFC4" /locus_tag="YOL094C" /coded_by="NM_001183348.1:1..972" /experiment="EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:8995429|PMID:12604797]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005663 DNA replication factor C complex [PMID:8063832]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006272 leading strand elongation [PMID:1346062]" /experiment="EXISTENCE:direct assay:GO:0007062 sister chromatid cohesion [PMID:11389843]" /experiment="EXISTENCE:direct assay:GO:0031389 Rad17 RFC-like complex [PMID:12604797]" /experiment="EXISTENCE:physical interaction:GO:0031389 Rad17 RFC-like complex [PMID:10660302]" /experiment="EXISTENCE:physical interaction:GO:0031390 Ctf18 RFC-like complex [PMID:11389843]" /experiment="EXISTENCE:physical interaction:GO:0031391 Elg1 RFC-like complex [PMID:12909721|PMID:12912927]" /note="Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:854059" /db_xref="SGD:S000005454" ORIGIN 1 msktlslqlp wvekyrpqvl sdivgnketi drlqqiakdg nmphmiisgm pgigkttsvh 61 clahellgrs yadgvlelna sddrgidvvr nqikhfaqkk lhlppgkhki vildeadsmt 121 agaqqalrrt melysnstrf afacnqsnki ieplqsrcai lrysklsded vlkrllqiik 181 ledvkytndg leaiiftaeg dmrqainnlq stvaghglvn adnvfkivds phplivkkml 241 lasnledsiq ilrtdlwkkg yssidivtts frvtknlaqv kesvrlemik eiglthmril 301 egvgtylqla smlakihkln nka // LOCUS NP_014548 293 aa linear PLN 30-JUN-2025 DEFINITION tRNA (guanine(9)-N(1))-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014548 VERSION NP_014548.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183347.1 REFERENCE 1 (residues 1 to 293) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 293) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 293) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 293) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10691. Method: conceptual translation. FEATURES Location/Qualifiers source 1..293 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..293 /product="tRNA (guanine(9)-N(1))-methyltransferase" /EC_number="2.1.1.221" /calculated_mol_wt="34389" Region 97..271 /region_name="SPOUT_Trm10-like" /note="tRNA methyltransferase Trm10-like; cd18089" /db_xref="CDD:349962" Site order(186..188,205..206,208,210,212,214,217..218,230..232, 245..246,248,251) /site_type="other" /note="SAM binding site [chemical binding]" /db_xref="CDD:349962" CDS 1..293 /gene="TRM10" /locus_tag="YOL093W" /coded_by="NM_001183347.1:1..882" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016423 tRNA (guanine) methyltransferase activity [PMID:12702816]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:12702816]" /note="tRNA methyltransferase; methylates N-1 of guanine at position 9 in tRNAs; involved in methylation of guanosine and uridine ribonucleosides in mRNA; involved in distinct tRNA quality control pathway for tRNA-Trp; member of SPOUT (SpoU-TrmD) methyltransferase family; human ortholog TRMT10A plays role in pathogenesis of microcephaly and early onset diabetes; an 18-mer ncRNA translational regulator originates from TRM10 locus; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854060" /db_xref="SGD:S000005453" ORIGIN 1 msndeinqne ekvkrtpplp pvpegmskkq wkkmckrqrw eenkakynae rrvkkkrlrh 61 ersakiqeyi drgeevpqel ireprinvnq tdsgieiild csfdelmndk eivslsnqvt 121 raysanrran hfaeikvapf dkrlkqrfet tlkntnyenw nhfkflpddk imfgdehisk 181 dkivyltadt eekleklepg mryivggivd knrykelclk kaqkmgiptr rlpideyinl 241 egrrvlttth vvqlmlkyfd dhnwknafes vlpprkldae aksassspap kdt // LOCUS NP_014549 308 aa linear PLN 30-JUN-2025 DEFINITION cationic amino acid transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_014549 VERSION NP_014549.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183346.1 REFERENCE 1 (residues 1 to 308) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 308) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 308) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 308) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 308) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10692. Method: conceptual translation. FEATURES Location/Qualifiers source 1..308 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..308 /product="cationic amino acid transporter" /calculated_mol_wt="34742" Region <28..70 /region_name="PQ-loop" /note="PQ loop repeat; pfam04193" /db_xref="CDD:461220" Region 137..>308 /region_name="MATE_like" /note="Multidrug and toxic compound extrusion family and similar proteins; cl09326" /db_xref="CDD:447704" Region 211..271 /region_name="PQ-loop" /note="PQ loop repeat; pfam04193" /db_xref="CDD:461220" CDS 1..308 /gene="YPQ1" /locus_tag="YOL092W" /coded_by="NM_001183346.1:1..927" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:22842922|PMID:23169667]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0015174 basic amino acid transmembrane transporter activity [PMID:23169667]" /experiment="EXISTENCE:mutant phenotype:GO:0034488 basic amino acid transmembrane export from vacuole [PMID:23169667]" /note="Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication" /db_xref="GeneID:854061" /db_xref="SGD:S000005452" ORIGIN 1 mqlvplelnr stlsgisgsi siscwiivfv pqiyenfyrk ssdglsllfv vlwlagdvfn 61 lmgavmqhll stmiilaayy tvadiillgq clwydneekp avdpihlspa npinenvlhd 121 vfneqqplln sqgqpnride emaapssdgn agddnlrevn srnlikdifi vsgvvfvgfi 181 swyvtycvny tqpppvedps lpvpelqinw maqifgylsa llylgsripq illnfkrksc 241 egisflfflf aclgnttfif svivisldwk ylimnaswlv gsigtlfmdf vifsqffiyk 301 rnkkfiln // LOCUS NP_014550 609 aa linear PLN 30-JUN-2025 DEFINITION Spo21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014550 VERSION NP_014550.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183345.1 REFERENCE 1 (residues 1 to 609) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 609) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 609) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 609) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10693. Method: conceptual translation. FEATURES Location/Qualifiers source 1..609 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..609 /product="Spo21p" /calculated_mol_wt="69748" Region <236..>450 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" CDS 1..609 /gene="SPO21" /locus_tag="YOL091W" /gene_synonym="MPC70" /coded_by="NM_001183345.1:1..1830" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12796288]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0035974 meiotic spindle pole body [PMID:10899120]" /experiment="EXISTENCE:genetic interaction:GO:0032120 ascospore-type prospore membrane formation [PMID:10899120]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12796288]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:10899120]" /note="Component of the meiotic outer plaque of the spindle pole body; involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation; SPO21 has a paralog, YSW1, that arose from the whole genome duplication" /db_xref="GeneID:854062" /db_xref="SGD:S000005451" ORIGIN 1 mdnilkasnm egtstmtvts rssedsscis nheqdtdthk dgdtsglens kiskrkwmke 61 ffklskspas kssrsigsmk snqslvsmks sddgnsyknd yssicgnslp saglsrsnsv 121 kelkldstgs qrsknnvaml arssttsqtt cssssssssy nsikgnendi llqnnnhfrh 181 nkeipqskgs snintasims qynvdtqata imsdmqkqyd sqqmtspfvn edlhfdpnge 241 vshvikaifk eigykyddfs dipvfqlmqe myqlvkknss arrtkitdya sklkekeaql 301 ksqndkilkl ettnkayktk ykevslenkk ikeafkeldn esynhdeell kkykytretl 361 drvnreqqli idqneflkks vnelqnevna tnfkfslfke kyakladsit elntstkkre 421 algenltfec nelkeiclky kknienisnt nknlqnsfkn erkkvldlrn ernllkkeil 481 liechgsysl llvsniltcy rfllpsdtii eteslikell nmnnslsnhv sssdeppaey 541 skrlelkcve feekllyfyq elvtkkiidv iykcfinyyk ksrqtdqksn qnsstpykqs 601 qrqvphsik // LOCUS NP_014551 964 aa linear PLN 30-JUN-2025 DEFINITION mismatch repair ATPase MSH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014551 VERSION NP_014551.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183344.1 REFERENCE 1 (residues 1 to 964) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 964) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 964) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 964) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 964) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10694. Method: conceptual translation. FEATURES Location/Qualifiers source 1..964 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..964 /product="mismatch repair ATPase MSH2" /calculated_mol_wt="108754" Region 19..128 /region_name="MutS_I" /note="MutS domain I; pfam01624" /db_xref="CDD:426350" Region 157..897 /region_name="MutS" /note="DNA mismatch repair ATPase MutS [Replication, recombination and repair]; COG0249" /db_xref="CDD:440019" CDS 1..964 /gene="MSH2" /locus_tag="YOL090W" /gene_synonym="PMS5" /coded_by="NM_001183344.1:1..2895" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:10882115]" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:10066781|PMID:9018043]" /experiment="EXISTENCE:direct assay:GO:0000403 Y-form DNA binding [PMID:16781730]" /experiment="EXISTENCE:direct assay:GO:0000404 heteroduplex DNA loop binding [PMID:16781730]" /experiment="EXISTENCE:direct assay:GO:0000406 double-strand/single-strand DNA junction binding [PMID:16781730]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:9545323]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9819445]" /experiment="EXISTENCE:direct assay:GO:0032135 DNA insertion or deletion binding [PMID:8805366]" /experiment="EXISTENCE:direct assay:GO:0032137 guanine/thymine mispair binding [PMID:8816473]" /experiment="EXISTENCE:direct assay:GO:0032138 single base insertion or deletion binding [PMID:8816473]" /experiment="EXISTENCE:genetic interaction:GO:0000735 removal of nonhomologous ends [PMID:9256462]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:16157874]" /experiment="EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:8056309|PMID:1334021|PMID:16702432]" /experiment="EXISTENCE:mutant phenotype:GO:0000735 removal of nonhomologous ends [PMID:10523644|PMID:9256462]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:10523644|PMID:9520271]" /experiment="EXISTENCE:mutant phenotype:GO:0006310 DNA recombination [PMID:15920474]" /experiment="EXISTENCE:mutant phenotype:GO:0006311 meiotic gene conversion [PMID:1334021]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:8849883]" /experiment="EXISTENCE:mutant phenotype:GO:0032138 single base insertion or deletion binding [PMID:9111312]" /experiment="EXISTENCE:mutant phenotype:GO:0043111 replication fork arrest [PMID:27045900]" /experiment="EXISTENCE:physical interaction:GO:0032301 MutSalpha complex [PMID:8816473]" /experiment="EXISTENCE:physical interaction:GO:0032302 MutSbeta complex [PMID:8805366]" /note="Protein that binds to DNA mismatches; forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity and involved in interstrand cross-link repair; Msh2p-Msh6p binds to and hydrolyzes ATP; required for silencing at the silent mating-type loci and telomeres" /db_xref="GeneID:854063" /db_xref="SGD:S000005450" ORIGIN 1 msstrpelkf sdvseernfy kkytglpkkp lktirlvdkg dyytvigsda ifvadsvyht 61 qsvlkncqld pvtaknfhep tkyvtvslqv latllklcll dlgykveiyd kgwkliksas 121 pgnieqvnel mnmnidssii iaslkvqwns qdgnciigva fidttaykvg mldivdnevy 181 snlesfliql gvkeclvqdl tsnsnsnaem qkvinvidrc gcvvtllkns efsekdveld 241 ltkllgddla lslpqkyskl smgacnalig ylqllseqdq vgkyelvehk lkefmkldas 301 aikalnlfpq gpqnpfgsnn lavsgftsag nsgkvtslfq llnhcktnag vrllnewlkq 361 pltnideink rhdlvdylid qielrqmlts eylpmipdir rltkklnkrg nledvlkiyq 421 fskripeivq vftsfledds ptepvnelvr svwlaplshh veplskfeem vettvdlday 481 eennefmikv efneelgkir skldtlrdei hsihldsaed lgfdpdkklk lenhhlhgwc 541 mrltrndake lrkhkkyiel stvkagiffs tkqlksiane tnilqkeydk qqsalvreii 601 nitltytpvf eklslvlahl dviasfahts syapipyirp klhpmdserr thlissrhpv 661 lemqddisfi sndvtlesgk gdfliitgpn mggkstyirq vgvislmaqi gcfvpceeae 721 iaivdailcr vgagdsqlkg vstfmveile tasilknask nsliivdelg rgtstydgfg 781 lawaiaehia skigcfalfa thfheltels eklpnvknmh vvahieknlk eqkhddedit 841 llykvepgis dqsfgihvae vvqfpekivk makrkaneld dlktnnedlk kaklslqevn 901 egnirlkall kewirkvkee glhdpskite easqhkiqel lraianepek endnylkyik 961 alll // LOCUS NP_014552 1030 aa linear PLN 30-JUN-2025 DEFINITION Hal9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014552 VERSION NP_014552.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183343.1 REFERENCE 1 (residues 1 to 1030) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1030) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1030) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1030) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1030) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1030) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1030) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1030) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1030) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10695. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1030 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1030 /product="Hal9p" /calculated_mol_wt="117796" Region 130..171 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(131,135,140..143,145,148,161) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(136,139,146,156,159,166) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 390..653 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..1030 /gene="HAL9" /locus_tag="YOL089C" /coded_by="NM_001183343.1:1..3093" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:9559673]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9559673|PMID:11943786]" /note="Transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression; HAL9 has a paralog, TBS1, that arose from the whole genome duplication" /db_xref="GeneID:854064" /db_xref="SGD:S000005449" ORIGIN 1 menqggdysp ngfsnsasnm navfnneitg rsdisnvnhq tgtprlvpet qiwsmpvpdq 61 lmtmpnrent lmtgstigpn ipmnvaypnt iysptehqsq fqtqqnrdis tmmehtnsnd 121 msgsgknlkk rvskacdhcr krkircdevd qqtkkcsnci kfqlpctfkh rdeilkkkrk 181 leikhhatpg eslqtsnsis npvasssvpn sgrfellngn splesniidk vsniqnnlnk 241 kmnskiekld rkmsyiidsv arlewlldka vkkqegkyke knnlpkpark iystalltaq 301 klywfkqslg vkasneefls piseilsisl kwyatqmkkf mdlsspaffs seiilyslpp 361 kkqakrllen fhatllssvt giislkecld laekyysesg ekltypehll lnvclcsgas 421 atqsiirgds kflrkdrydp tsqelkkien vallnamyyy hklsticsgt rtlqalllln 481 ryfqltydte lancilgtai rlavdmelnr kssyksldfe eairrrrmww hcfctdklys 541 lmlsrppivg erdmdmltdq nyyeviktni lpdlidkked ldkitdvnsa lnvvvnfcqh 601 islfisyyvs klvsieskiy stcfavrstl dlsfdamldk ikdlndslnn wrdnlhvsmk 661 lksykqylsv lyaqksqenp alsfeiacsr vlnchfraly skvilsmmtt sllidnerly 721 kgsrhdipql filfssqyln askemlqlfq ginyqahmyn evmyqfstam fvlffyvvdn 781 mndlkkkgev keiidilkks ydrlvgende qllfdnvkwn tlivfyshfl kyvlqryhal 841 ndstsifdsk pydetitkvi mhsrkikdet vdqlimslks ygslhslqkg neadladdgl 901 ntndissedf aeeapinlfg elsveilkll kshspisnfg dlspssnrkg isddsslypi 961 rsdltslvyp ihssdtgdtl ssgletpens nfnsdsgike dfeafrallp lgkliydrdy 1021 sfvntfrdye // LOCUS NP_014553 277 aa linear PLN 30-JUN-2025 DEFINITION protein disulfide isomerase MPD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014553 VERSION NP_014553.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183342.1 REFERENCE 1 (residues 1 to 277) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 277) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 277) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 277) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10696. Method: conceptual translation. FEATURES Location/Qualifiers source 1..277 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..277 /product="protein disulfide isomerase MPD2" /EC_number="5.3.4.1" /calculated_mol_wt="32270" Region <48..170 /region_name="Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold" /note="The thioredoxin (TRX)-like superfamily is a large, diverse group of proteins containing a TRX fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox...; cl00388" /db_xref="CDD:469754" CDS 1..277 /gene="MPD2" /locus_tag="YOL088C" /coded_by="NM_001183342.1:1..834" /experiment="EXISTENCE:direct assay:GO:0003756 protein disulfide isomerase activity [PMID:16002399]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015035 protein-disulfide reductase activity [PMID:16002399]" /experiment="EXISTENCE:genetic interaction:GO:0003756 protein disulfide isomerase activity [PMID:11157982]" /experiment="EXISTENCE:genetic interaction:GO:0005783 endoplasmic reticulum [PMID:15377672]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:11157982]" /experiment="EXISTENCE:genetic interaction:GO:0015035 protein-disulfide reductase activity [PMID:11157982]" /experiment="EXISTENCE:mutant phenotype:GO:0003756 protein disulfide isomerase activity [PMID:11157982]" /note="Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p" /db_xref="GeneID:854065" /db_xref="SGD:S000005448" ORIGIN 1 mklhgflfsv lstcvvilpa layseavtmv ksieqyfdic nrndsytmik yytswcqhck 61 tlapvyeelg elyakkankd dtpinflevn ceffgptlct dlpgfpiiel vkprtkplvl 121 pkldwssmkf herlwqrikt wfnnpkyqld tsrvvrfegs rnlkslsnfi dtvrskdtee 181 rfiehifdds rncneelrsq qllckagkey ysdtlsklyg dvnglekerr rlealikqng 241 ddlskevkek lkiirlqlsl lshiedqled tsshdel // LOCUS NP_014554 1116 aa linear PLN 30-JUN-2025 DEFINITION Duf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014554 VERSION NP_014554.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183341.1 REFERENCE 1 (residues 1 to 1116) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1116) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1116) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1116) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10697. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1116 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1116 /product="Duf1p" /calculated_mol_wt="125252" Region 10..296 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(21..22,42,46,52,54,77..78,103,107,122..123,130, 142..143,155,161,180,184,190..191,212..213,241,246, 252..253,266..267,285,289,295..296) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 165..207 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 218..264 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 271..309 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 337..383 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 392..418 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 1018..1098 /region_name="Ubl_WDR48" /note="Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; cd17041" /db_xref="CDD:340561" CDS 1..1116 /gene="DUF1" /locus_tag="YOL087C" /coded_by="NM_001183341.1:1..3351" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /note="Ubiquitin-binding hypothetical protein; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid" /db_xref="GeneID:854066" /db_xref="SGD:S000005447" ORIGIN 1 mnqltvsygl ispdyctsqd ahilpitkil ypdipgknyf ltsgrdgsii lhkntqlsne 61 petaattikn dairmqvhsd wasdlihvnm knsdpsagdt fisvshdfsi vlisvnaqlt 121 twdkkiigdh ddyikcivpi hyemsndyel eeqeggpdnv hdginngivv deqnnflfvt 181 ggldrkiklw clssgpekma tllhtfdnaq sndtgsiysm spiipkysfd dnqtsrpfdf 241 vagdcngdli fysckyrkev iriqnahrtn ikvvrtldds trlistssdg vinvwdlncr 301 hdqttgalql pkkigswswd ssiwcvqgts ldklyfgdsq gnvmranlss yedakltrif 361 kpdhhhhhhh hheheeqnis ttdakvkkyg gildiallpn ekllfsfctd snlnvldltn 421 nhfsvneggf altrsslltn rrhvitentk gqmqrwdivs cellntfdss egsfddivmk 481 ytskeilshw ctvsvkvgml fvkinpkflk tevygsalkd yqvvnniein sderynlgki 541 vinslfnefi syevqkdkll rkkifslkkk dltnsltldt gynseskknn kdkkrkstfk 601 isstlsignt nssgtppnsa patpvmaeti vleeqpllqs asdkaiddsl elvqplpask 661 kpyfrtqssg sllsrkfksf rstsgrattg lntpeepkgi lpdtphvind dsafpqaint 721 tqqskdatpe smlwnhpfkl eqklsaissq dlpsnnthnk lrssensran ststlegnek 781 kkpefmpdll eqiqesykqq ymntsslkyl tkrlpvtkii kasscpiirv ksatlvlvhl 841 wkegscggrv lfstllppsh vdnetvsggk enskppddee vdlqavdddk lgkydlidge 901 lgsrlnrrqi feqleenlpy wfakalfrdi ktveeqpkln flimpwssvg gseaagnenk 961 kkfisasdtt essgndssds slgngneavs pstqqqfhnm lkfgrpktse qelnptdlpr 1021 iseanvklva pgmirvkkik lyvadrfetk tpemkakmep slwldllcrg qvldndmtln 1081 tvrtlywksq gdivleyrrk vhnsplvhev ngnegk // LOCUS NP_076910 90 aa linear PLN 30-JUN-2025 DEFINITION Mhf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_076910 VERSION NP_076910.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184492.1 REFERENCE 1 (residues 1 to 90) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 90) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 90) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 90) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10698. Method: conceptual translation. FEATURES Location/Qualifiers source 1..90 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..90 /product="Mhf1p" /calculated_mol_wt="10418" Region 10..86 /region_name="HFD_CENP-S" /note="histone-fold domain found in centromere protein S (CENP-S) and similar proteins; cd22919" /db_xref="CDD:467044" Site order(10,13,17,21,24..25,31..34,36..37,40..41,44..46, 48..50,52..54,56..57,61,66..70,73,76,79..80,83,86) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467044" Site order(55,58..59,62..63,65,71..72,75,78..79) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:467044" CDS 1..90 /gene="MHF1" /locus_tag="YOL086W-A" /coded_by="NM_001184492.1:1..273" /experiment="EXISTENCE:direct assay:GO:0071821 FANCM-MHF complex [PMID:22325783]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:20347428]" /note="Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1" /db_xref="GeneID:854067" /db_xref="SGD:S000007626" ORIGIN 1 mnddedraql karlwirvee rlqqvlssed ikytprfins llelaylqlg emgsdlqafa 61 rhagrgvvnk sdlmlylrkq pdlqervtqe // LOCUS NP_014555 348 aa linear PLN 30-JUN-2025 DEFINITION alcohol dehydrogenase ADH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014555 VERSION NP_014555.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183340.1 REFERENCE 1 (residues 1 to 348) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 348) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 348) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 348) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 348) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10699. Method: conceptual translation. FEATURES Location/Qualifiers source 1..348 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..348 /product="alcohol dehydrogenase ADH1" /EC_number="1.1.1.1" /EC_number="1.1.1.54" /EC_number="1.1.1.78" /calculated_mol_wt="36718" Region 7..345 /region_name="CAD3" /note="Cinnamyl alcohol dehydrogenases (CAD); cd08297" /db_xref="CDD:176257" Site order(44..46,49,154,158,178,180..181,183,201..202,207, 246..249,252,269..271,294..296,341) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:176257" Site order(44,46,55,67,93,154,271,296) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:176257" Site order(44,67,154) /site_type="other" /note="catalytic Zn binding site [ion binding]" /db_xref="CDD:176257" Site order(55,100,102..103,111..113,169..171,193..195,197,209, 212..213,253,261,263,268,270..271,281..282,287..295, 299..300,304,308,311) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:176257" Site order(98,101,104,112) /site_type="other" /note="structural Zn binding site [ion binding]" /db_xref="CDD:176257" CDS 1..348 /gene="ADH1" /locus_tag="YOL086C" /gene_synonym="ADC1" /coded_by="NM_001183340.1:1..1047" /experiment="EXISTENCE:direct assay:GO:0004022 alcohol dehydrogenase (NAD+) activity [PMID:6985717]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:2937632]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0019170 methylglyoxal reductase (NADH) activity [PMID:12722185]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:genetic interaction:GO:0000947 amino acid catabolic process to alcohol via Ehrlich pathway [PMID:12499363]" /experiment="EXISTENCE:mutant phenotype:GO:0019655 glycolytic fermentation to ethanol [PMID:15082781]" /note="Alcohol dehydrogenase; fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway; ADH1 has a paralog, ADH5, that arose from the whole genome duplication" /db_xref="GeneID:854068" /db_xref="SGD:S000005446" ORIGIN 1 msipetqkgv ifyeshgkle ykdipvpkpk anellinvky sgvchtdlha whgdwplpvk 61 lplvgghega gvvvgmgenv kgwkigdyag ikwlngscma ceycelgnes ncphadlsgy 121 thdgsfqqya tadavqaahi pqgtdlaqva pilcagitvy kalksanlma ghwvaisgaa 181 gglgslavqy akamgyrvlg idggegkeel frsiggevfi dftkekdivg avlkatdgga 241 hgvinvsvse aaieastryv rangttvlvg mpagakccsd vfnqvvksis ivgsyvgnra 301 dtrealdffa rglvkspikv vglstlpeiy ekmekgqivg ryvvdtsk // LOCUS NP_001335813 113 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL085C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335813 VERSION NP_001335813.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348875.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80333. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..113 /product="uncharacterized protein" /calculated_mol_wt="12650" CDS 1..113 /locus_tag="YOL085C" /coded_by="NM_001348875.1:1..342" /note="hypothetical protein; conserved among S. cerevisiae strains; YOL085C is not an essential gene; partially overlaps dubious ORF YOL085W-A" /db_xref="GeneID:854069" /db_xref="SGD:S000005445" ORIGIN 1 mkakdkykgr tknkvksvdm mylalrrrkn eftqlhnhad svadprscrp gdnagreavp 61 ggvfcacifq glpcakgrdw rsnknagwgc ddddhdnwch ylscrknlsa fat // LOCUS NP_014557 991 aa linear PLN 30-JUN-2025 DEFINITION Phm7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014557 VERSION NP_014557.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183338.1 REFERENCE 1 (residues 1 to 991) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 991) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 991) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 991) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 991) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 991) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 991) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 991) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 991) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10700. Method: conceptual translation. FEATURES Location/Qualifiers source 1..991 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..991 /product="Phm7p" /calculated_mol_wt="112415" Region 4..985 /region_name="COG5594" /note="Uncharacterized integral membrane protein [Function unknown]" /db_xref="CDD:227881" CDS 1..991 /gene="PHM7" /locus_tag="YOL084W" /coded_by="NM_001183338.1:1..2976" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006817 phosphate ion transport [PMID:36592238]" /note="hypothetical protein; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854070" /db_xref="SGD:S000005444" ORIGIN 1 madssstsaf istliiyglt avvfvwlfll lrpknrrvye prslkdiqti peeertepvp 61 egyfgwveyl lskphsfliq htsvdgyfll ryigivgsls fvgcllllpi llpvnatngn 121 nlqgfellsf snvtnknrfy ahvflswiff glftyviyke lyyyvvfrha mqttplydgl 181 lssrtvivte lhksiaqege mqmrfpkasn vafaydlsdl qelckerakn aakyeaalnk 241 vlnkcvkmtr nktqkqldkl ynngtkpkdd letyvphkkr pkhrlgklpl clggkkvntl 301 sysskrigel neeihekqad wasndrqpac fiqfetqlea qrcyqsveai lgkknfgkrl 361 igyspedvnw gsmrlssker hsrravanti mvlliifwaf pvavvgiisn vnfltdkvpf 421 lrfinnmptf lmgvitgllp tialvvlmsl vppfivmlgk lsgcvtrqet dlysqawyya 481 faviqiflvv tatssasstv dsiidrprsa mtllannlpk asnfyimyfi lkgltgptwt 541 ilqavnllls kvlgrvldst prqkwnrynt latprmgivy pgieilvciy icysiiapil 601 lffstvmltl lyvaylynln yvfgfsfdlk grnypralfq ifvgiylsev cllglfimak 661 twgplvlevf wivvtalahi ymkrkfiplf davplsairh argepgysyp tsdlglqeik 721 diademkgky eqdnthgilt pvtkddlkka nlipdndgss engtpsnpfe sgseraslsg 781 snaesdsikk lndtvikkss tlssstkdnn estfvpegek frkfhysdve alrnkrpyde 841 ddhskhgpeg avpvnadagv iysdpaavmk epqafppdvl etntwtrril qffnprrsyp 901 fdsvrmrfpl vfntsieyde eylssaytdp cvrekdpivw cckdplgvsk qqiqearsng 961 ldvrddftry dekgkvifty nppdyepeak k // LOCUS NP_014558 412 aa linear PLN 30-JUN-2025 DEFINITION Atg34p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014558 VERSION NP_014558.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183337.1 REFERENCE 1 (residues 1 to 412) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 412) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 412) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 412) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10701. Method: conceptual translation. FEATURES Location/Qualifiers source 1..412 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..412 /product="Atg34p" /calculated_mol_wt="46524" Region 164..412 /region_name="ABD" /note="Alpha-Mannosidase Binding Domain of Atg19/34; cl42397" /db_xref="CDD:455742" Site 296..297 /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:213406" CDS 1..412 /gene="ATG34" /locus_tag="YOL083W" /coded_by="NM_001183337.1:1..1239" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0034270 Cvt complex [PMID:20639194|PMID:20659891]" /experiment="EXISTENCE:genetic interaction:GO:0016236 macroautophagy [PMID:20639194]" /experiment="EXISTENCE:genetic interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:20639194]" /experiment="EXISTENCE:genetic interaction:GO:0031503 protein-containing complex localization [PMID:20639194|PMID:20659891]" /experiment="EXISTENCE:genetic interaction:GO:0071211 protein targeting to vacuole involved in autophagy [PMID:20639194]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:20639194]" /note="Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog" /db_xref="GeneID:854071" /db_xref="SGD:S000005443" ORIGIN 1 mkiavettlf dffvidqfkk stfsapntkv dtikgcinkf ieqfnvydeq hifwqppgks 61 nvrllsnand fgqlgnflhk kikcnifige ealrkydlni cgpydkfven sdpsvkkvvn 121 rddvmlsrkc lniiseqlsi leksiskaqn qvlqsseveg kkciilpedk pelikffskf 181 etsvqlqevy egykvyekll qkfggqkkrm esflnentpm sgaeaikqin iseelkekge 241 rlttpndpll hvevsnedns lhfilynktn iiipgnctfe fssqisevfs ikmgpheigi 301 kgqkelwffp slptplsnyt mkvvnqdget ilvgkcadsn eitlksplas fstgsfqtgs 361 fhtlqdptnv fradalsspd essimstpfl getdevynsg stlsrpftwe ei // LOCUS NP_014559 415 aa linear PLN 30-JUN-2025 DEFINITION Atg19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014559 VERSION NP_014559.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183336.1 REFERENCE 1 (residues 1 to 415) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 415) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 415) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 415) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10702. Method: conceptual translation. FEATURES Location/Qualifiers source 1..415 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..415 /product="Atg19p" /calculated_mol_wt="47468" Region 259..362 /region_name="ABD" /note="Alpha-Mannosidase Binding Domain of Atg19/34; cd12213" /db_xref="CDD:213406" Site 310..311 /site_type="other" /note="ligand binding site [chemical binding]" /db_xref="CDD:213406" CDS 1..415 /gene="ATG19" /locus_tag="YOL082W" /gene_synonym="CVT19" /coded_by="NM_001183336.1:1..1248" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569|PMID:12479808]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11382752]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0034270 Cvt complex [PMID:11430817|PMID:20659891|PMID:12479808]" /experiment="EXISTENCE:genetic interaction:GO:0031503 protein-containing complex localization [PMID:20659891]" /experiment="EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:15138258]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:12479808]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:12479807|PMID:12479808|PMID:11430817|PMID:20659891]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:17238920]" /note="Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles; interaction with Atg19p during the Cvt pathway requires phosphorylation by Hrr25p" /db_xref="GeneID:854072" /db_xref="SGD:S000005442" ORIGIN 1 mnnsktnqqm ntsmgypltv ydecnkfqli vptldaniml wcigqlslln dsngckhlfw 61 qpndksnvri llnnydyghl fkylqcqrkc svyigegtlk kynltistsf dnfldltpse 121 ekeslcreda hedpvspkag seeeispnst snvvvsrecl dnfmkqllkl eeslnklele 181 qkvtnkepnh risgtidipe drselvnfft elktvkqled vfqryhdyer lsqecdskte 241 iasdhskket kieveppner slqitmnqrd nslyfqlfnn tnsvlagnck lkftdagdkp 301 ttqiidmgph eigikeykey ryfpyaldle agstieienq ygeviflgky gsspminlrp 361 psrlsaeslq asqepfysfq idtlpeldds siistsisls ydgddnekal tweel // LOCUS NP_014560 3079 aa linear PLN 30-JUN-2025 DEFINITION Ras GTPase activating protein IRA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014560 VERSION NP_014560.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183335.1 REFERENCE 1 (residues 1 to 3079) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 3079) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 3079) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 3079) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 3079) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 3079) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 3079) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 3079) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 3079) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10703. Method: conceptual translation. FEATURES Location/Qualifiers source 1..3079 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..3079 /product="Ras GTPase activating protein IRA2" /calculated_mol_wt="351539" Region 1672..1990 /region_name="RasGAP_Neurofibromin_like" /note="Ras-GTPase Activating Domain of proteins similar to neurofibromin; cd05392" /db_xref="CDD:213341" Site order(1702,1738,1740,1742..1743,1745,1748,1752,1843, 1851..1852,1855..1856,1859,1879,1882..1883,1886,1890,1892, 1897..1898) /site_type="other" /note="putative RAS interface [polypeptide binding]" /db_xref="CDD:213341" CDS 1..3079 /gene="IRA2" /locus_tag="YOL081W" /gene_synonym="CCS1; GLC4" /coded_by="NM_001183335.1:1..9240" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:7577970]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:22575457]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:22575457]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:2178777]" /experiment="EXISTENCE:mutant phenotype:GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway [PMID:2164637|PMID:15629464]" /experiment="EXISTENCE:mutant phenotype:GO:0046580 negative regulation of Ras protein signal transduction [PMID:15339905]" /note="GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; IRA2 has a paralog, IRA1, that arose from the whole genome duplication; defects in human homolog NF1 are associated with neurofibromatosis" /db_xref="GeneID:854073" /db_xref="SGD:S000005441" ORIGIN 1 msqptknkkk ehgtdskssr mtrtlvnhil ferilpilpv esnlstysev eeyssfiscr 61 svlinvtvsr danamvegtl eliesllqgh eiisdkgssd viesiliilr llsdaleynw 121 qnqeslhynd isthvehdqe qkyrpklnsi lpdyssthsn gnkhffhqsk pqalipelas 181 kllescaklk fntrtlqilq nmishvhgni lttlsssilp rhksyltrhn hpshckmids 241 tlghilrfva asnpseyfef irksvqvpvt qththshshs hslpssvyns ivphfdlfsf 301 iylskhnfkk yleliknlsv tlrktiyhcl llhysakaim fwimarpaey yelfnllkdn 361 nnehskslnt lnhtlfeeih stfnvnsmit tnqnahqgss spsssspssp psssssdnnn 421 qniiakslsr qlshhqsyiq qqserklhss wttnsqssts lssstsnstt tdfsthtqpg 481 eydpslpdtp tmsnitisas sllsqtptpt tqlqqrlnsa aaaaaaaasp snstptgyta 541 eqqsrasyda hktghtgkdy dehflsvtrl dnvlelythf ddtevlphts vlkflttltm 601 fdidlfneln atsfkyipdc tmhrpkerts sfnntahetg sektsgikhi tqglkkltsl 661 psstkktvkf vkmllrnlng nqavsdvall dtmrallsff tmtsavflvd rnlpsvlfak 721 rlipimgtnl svgqdwnski nnslmvclkk nsttfvqlql iffssaiqfd helllarlsi 781 dtmannlnmq klclytegfr iffdipskke lrkaiavkis kffktlfsii adillqefpy 841 fdeqitdiva sildgtiine ygtkkhfkgs spslcsttrs rsgstsqssm tpvsplgldt 901 dicpmntlsl vgsstsrnsd nvnslnsspk nlssdpylsh lvaprarhal ggpssiirnk 961 ipttltsppg teksspvqrp qtesisatpm aitnstplss aafgirsplq kirtrrysde 1021 slgkfmkstn nyiqehlipk dlneatlqda rriminifsi fkrpnsyfii phninsnlqw 1081 vsqdfrnimk pifvaivspd vdlqntaqsf mdtllsnvit ygesdenisi egyhllcsyt 1141 vtlfamglfd lkinnekrqi llditvkfmk vrshlagiae ashhmeyisd sekltfplim 1201 gtvgralfvs lyssqqkiek tlkiayteyl sainfherni ddadktwvhn iefveamchd 1261 nyttsgsiaf qrrtrnnilr fatipnaill dsmrmiykkw htythsksle kqerndfrnf 1321 agilaslsgi lfinkkilqe mypylldtvs elkknidsfi skqcqwlnyp dlltrensrd 1381 ilsvelhpls fnllfnnlrl klkelacsdl sipenessyv lleqiikmlr tilgrdddny 1441 vmmlfsteiv dlidlltdei kkipaycpky lkaiiqmtkm fsalqhsevn lgvknhfhvk 1501 nkwlrqitdw fqvsiareyd fenlskplke mdlvkrdmdi lyidtaieas taiayltrht 1561 fleippaasd pelsrsrsvi fgfyfnilmk glekssdrdn ypvflrhkms vlndnvilsl 1621 tnlsntnvda slqftlpmgy sgnrnirnaf levfinivtn yrtytaktdl gkleaadkfl 1681 rytiehpqls sfgaavcpas didayaagli nafetrnath ivvaqlikne iekssrptdi 1741 lrrnscatrs lsmlarskgn eylirtlqpl lkkiiqnrdf feieklkped sdaerqielf 1801 vkymnelles isnsvsyfpp plfyicqniy kvacekfpdh aiiaagsfvf lrffcpalvs 1861 pdseniidis hlsekrtfis lakviqnian gsenfsrwpa lcsqkdflke csdrifrfla 1921 elcrtdrtid iqvrtdptpi afdyqflhsf vylyglevrr nvlneakhdd gdidgddfyk 1981 ttflliddvl gqlgqpkmef sneipiyire hmddypelye fmnrhafrni etstayspsv 2041 hestssegip iitltmsnfs drhvdidtva ykflqiyari wttkhcliid ctefdeggld 2101 mrkfislvmg llpevapknc igcyyfnvne tfmdnygkcl dkdnvyvssk iphyfinsns 2161 deglmksvgi tgqglkvlqd irvslhditl ydekrnrftp vslkigdiyf qvlhetprqy 2221 kirdmgtlfd vkfndvyeis rifevhvssi tgvaaeftvt fqderrlifs spkyleivkm 2281 fyyaqirles eyemdnnsst sspnsnnkdk qqkertkllc hlllvsligl fdeskkmkns 2341 synliaatea sfglnfgshf hrspevyvpe dtttflgvig kslaesnpel taymfiyvle 2401 alknnviphv yiphticgls ywipnlyqhv yladdeegpe nishifrili rlsvretdfk 2461 avymqyvwll llddgrltdi ivdevinhal erdsenrdwk ktislltvlp ttevanniiq 2521 kilakirsfl pslkleamtq swseltilvk isihvffets llvqmylpei lfivsllidv 2581 gprelrsslh qllmnvchsl ainsalpqdh rnnldeisdi fahqkvkfmf gfsedkgril 2641 qifsassfas kfnildffin nilllmeyss tyeanvwktr ykkyvlesvf tsnsflsars 2701 imivgimgks yiteglckam lietmkviae pkitdehlfl aishiftysk ivegldpnld 2761 lmkhlfwfst lflesrhpii fegallfvsn cirrlymaqf enesetslis tllkgrkfah 2821 tflskienls givwnednft hilifiinkg lsnpfiksta fdflkmmfrn syfehqinqk 2881 sdhylcymfl lyfvlncnqf eellgdvdfe gemvnienkn tipkillewl ssdnenanit 2941 lyqgailfkc svtdepsrfr faliirhllt kkpicalrfy svirneirki safeqnsdcv 3001 plafdilnll vthsesnsle klheesierl tkrglsivts sgifaknsdm mipldvkped 3061 iyerkrimtm ilsrmscsa // LOCUS NP_014561 289 aa linear PLN 30-JUN-2025 DEFINITION putative 3'-5' exonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_014561 VERSION NP_014561.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183334.1 REFERENCE 1 (residues 1 to 289) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 289) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 289) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 289) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10704. Method: conceptual translation. FEATURES Location/Qualifiers source 1..289 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..289 /product="putative 3'-5' exonuclease" /calculated_mol_wt="32764" Region 122..274 /region_name="REX4_like" /note="DEDDh 3'-5' exonuclease domain of RNA exonuclease 4, XPMC2, Interferon Stimulated Gene product of 20 kDa, and similar proteins; cd06144" /db_xref="CDD:99847" Site order(125..128,130,168,172,204..205,207..209,260,265) /site_type="active" /db_xref="CDD:99847" Site order(125..128,130,168,172,204..205,207..208,260,265) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:99847" Site order(125,127,209,260,265) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:99847" CDS 1..289 /gene="REX4" /locus_tag="YOL080C" /coded_by="NM_001183334.1:1..870" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000027 ribosomal large subunit assembly [PMID:12364601]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:12364601]" /note="Putative RNA exonuclease; possibly involved in pre-rRNA processing and ribosome assembly" /db_xref="GeneID:854075" /db_xref="SGD:S000005440" ORIGIN 1 malssnwqal lasesnptsn gknkqsnrki rnvkkvsktv nvssttqyap rkrkngskim 61 dmvynmnkei skhekdkleg kvfefnpnka ntsttikepv kvgisedtri nsnkskeigk 121 yiamdcefvg vgpegkesal arisivnyfg hvvldefvkp rekvvewrtw vsgikpehmk 181 naitfkeaqk ktadilegri lvghalkhdl ealmlshpks llrdtsrhlp frklyakgkt 241 pslkkltrev lkisiqegeh ssvedaratm llykkektef ekihrntfn // LOCUS NP_014563 1176 aa linear PLN 30-JUN-2025 DEFINITION Avo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014563 VERSION NP_014563.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183332.1 REFERENCE 1 (residues 1 to 1176) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1176) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1176) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1176) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10705. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1176 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1176 /product="Avo1p" /calculated_mol_wt="131248" Region 638..786 /region_name="CRIM" /note="SAPK-interacting protein 1 (Sin1), middle CRIM domain; pfam16978" /db_xref="CDD:465326" Region 1066..1172 /region_name="PH_Avo1" /note="Avo1 Pleckstrin homology (PH) domain; cd13331" /db_xref="CDD:270139" Site order(1068..1071,1084..1088,1112,1131,1147..1150,1156, 1159..1160,1163) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:270139" Site order(1073,1075..1076,1083,1085,1109..1110,1112,1145,1147) /site_type="other" /note="putative phosphoinositide binding site [chemical binding]" /db_xref="CDD:270139" CDS 1..1176 /gene="AVO1" /locus_tag="YOL078W" /coded_by="NM_001183332.1:1..3531" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:19144819]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19144819]" /experiment="EXISTENCE:mutant phenotype:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:16002396]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0005737 cytoplasm [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0030950 establishment or maintenance of actin cytoskeleton polarity [PMID:12408816]" /experiment="EXISTENCE:physical interaction:GO:0031932 TORC2 complex [PMID:12408816]" /note="Subunit of TORC2, a regulator of plasma membrane (PM) homeostasis; C-terminal PH domain binds to phosphoinositide-(4,5)-bisphosphate (PI(4,5)P2); binds directly to Ypk2p a Tor2p substrate and downstream TORC2 effector through a conserved central CRIM domain; acts with Tsc11p as a scaffold important for the integrity of the TORC2 complex; dispensable for PM localization of TORC2; role in regulating actin organization and growth control; orthologous to human MAPKAP1/SIN1" /db_xref="GeneID:854076" /db_xref="SGD:S000005438" ORIGIN 1 mdtvtvlnel raqflrvcpe kdqmkriikp yipvdefnte qcldssirel ymnsdgvsll 61 pelesppvsk dfmenyaslg kmrimreneg qkgkanqnli gaekterdee etrnlqdksa 121 kntliveeng tlrynplnss asnsllnddd htsgkhhkts skedsylnss memqkksskr 181 sslpfvrifk srrdhsntsg nknvmnttnt raksstlhpp garhnkkgsk fdmnfdfden 241 leeedddddd deegddihsq ffqldddfda kgsgaspahk gingmsnnkn ntytnnrnsi 301 silddressn gnigsasrlk shfptsqkgk ifltdnkndg qksdslnank gihgdgssas 361 gngsvsrdgl tetesnnisd mesyinekdl ddlnfdtvts ninktvsdlg ghestndgta 421 vmnrdskdsr snsnefnaqn rdritpgssy gksllgseys eerysnndss tmesgemsld 481 sdmqtntips hsipmsmqky giyhgdddst lnnvfdkavl tmnssrhpke rrdtvisgke 541 ptsltssnrk fsvssnltst rspllrghgr tsstassehm kapkvsdsvl hrarkstltl 601 kqdhsqpsvp ssvhksskeg niliekttdy lvskpkasql snmfnkkkkr tntnsvdvle 661 yfsfvcgdkv pnyesmglei yiqaskkykr nsfttkvrks stifevigfa lflystekkp 721 dnfeedgltv edisnpnnfs lkivdedgep fednfgkldr kstiqsisds evvlckvdda 781 eksqneietp lpfetggglm dastldanss hdttdgtinq lsfykpiign eddidktngs 841 kiidvtvyly pnvnpkfnyt tisvlvtshi ndilvkyckm knmdpneyal kvlgknyild 901 lndtvlrldg inkveliskk darelhlekm kpdlkkpvlp tiqsndltpl tleplnsylk 961 adaggavaai pentkvtska kkistkyklg lakqhssssv asgsvstagg langngffkn 1021 knssksslhg tlqfhninrs qstmehtpdt pngvgdnfqd lftgayhkyk vwrrqqmsfi 1081 nkhertlaid gdyiyivppe grihwhdnvk tkslhisqvv lvkkskrvpe hfkifvrreg 1141 qddikryyfe avsgqectei vtrlqnllsa yrmnhk // LOCUS NP_014564 68 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit k [Saccharomyces cerevisiae S288C]. ACCESSION NP_014564 VERSION NP_014564.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184377.1 REFERENCE 1 (residues 1 to 68) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 68) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 68) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 68) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10706. Method: conceptual translation. FEATURES Location/Qualifiers source 1..68 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..68 /product="F1F0 ATP synthase subunit k" /calculated_mol_wt="7403" Region 4..65 /region_name="ATP19" /note="ATP synthase subunit K; pfam11022" /db_xref="CDD:431614" CDS 1..68 /gene="ATP19" /locus_tag="YOL077W-A" /coded_by="NM_001184377.1:1..207" /experiment="EXISTENCE:curator inference:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:9857174]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:20219971]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:9857174]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:9857174]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:20219971]" /note="Subunit k of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase" /db_xref="GeneID:854077" /db_xref="SGD:S000007339" ORIGIN 1 mgaayhfmgk aipphqlaig tlgllgllvv pnpfksakpk tvdiktdnkd eekfienylk 61 khsekqda // LOCUS NP_014565 291 aa linear PLN 30-JUN-2025 DEFINITION ribosome biogenesis protein BRX1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014565 VERSION NP_014565.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183331.2 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10707. On Apr 26, 2011 this sequence version replaced NP_014565.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..291 /product="ribosome biogenesis protein BRX1" /calculated_mol_wt="33400" Region 1..291 /region_name="BRX1" /note="RNA-binding protein required for 60S ribosomal subunit biogenesis [Translation, ribosomal structure and biogenesis]; COG5154" /db_xref="CDD:227483" CDS 1..291 /gene="BRX1" /locus_tag="YOL077C" /coded_by="NM_001183331.2:1..876" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11843177]" /experiment="EXISTENCE:direct assay:GO:0008097 5S rRNA binding [PMID:11864606]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:11864606]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:11843177]" /experiment="EXISTENCE:mutant phenotype:GO:0000464 endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11843177]" /experiment="EXISTENCE:mutant phenotype:GO:0000465 exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11843177]" /note="Nucleolar protein; constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif" /db_xref="GeneID:854078" /db_xref="SGD:S000005437" ORIGIN 1 mssiykalag kskdnksekk qgnvkqfmnk qrtllissrg vnyrhrhliq dlsgllphsr 61 kepkldtkkd lqqlneiael yncnnvlffe arkhqdlylw lskppngpti kfyiqnlhtm 121 delnftgncl kgsrpvlsfd qrfessphyq likellvhnf gvppnarksk pfidhvmsfs 181 ivddkiwvrt yeishstknk eeyedgeedi slveigprfv mtvililegs fggpkiyenk 241 qyvspnvvra qikqqaaeea ksraeaaver kikrrenvla adplsndalf k // LOCUS NP_014566 796 aa linear PLN 30-JUN-2025 DEFINITION Mdm20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014566 VERSION NP_014566.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183330.1 REFERENCE 1 (residues 1 to 796) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 796) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 796) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 796) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10708. Method: conceptual translation. FEATURES Location/Qualifiers source 1..796 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..796 /product="Mdm20p" /calculated_mol_wt="92678" Region 270..591 /region_name="NatB_MDM20" /note="N-acetyltransferase B complex (NatB) non catalytic subunit; pfam09797" /db_xref="CDD:430834" CDS 1..796 /gene="MDM20" /locus_tag="YOL076W" /gene_synonym="DEC1; NAA25" /coded_by="NM_001183330.1:1..2391" /experiment="EXISTENCE:direct assay:GO:0031416 NatB complex [PMID:12783868]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:9105043]" /experiment="EXISTENCE:genetic interaction:GO:0017196 N-terminal peptidyl-methionine acetylation [PMID:12783868]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:12808144]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:9105043]" /experiment="EXISTENCE:mutant phenotype:GO:0004596 protein-N-terminal amino-acid acetyltransferase activity [PMID:12783868]" /experiment="EXISTENCE:mutant phenotype:GO:0007010 cytoskeleton organization [PMID:9105043]" /experiment="EXISTENCE:mutant phenotype:GO:0017196 N-terminal peptidyl-methionine acetylation [PMID:12783868]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:12808144]" /note="Non-catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly" /db_xref="GeneID:854079" /db_xref="SGD:S000005436" ORIGIN 1 msdkiqeeil glvsrsnfkq cyaklgqlqk qfpnalyfki letyvkfkqs pgkfdynkll 61 eepyglkgtt itgdtrslef lhnffvelgk ydealhvyer gnfkfpsyel syhwfmkale 121 dsnynqmska slqlakysds gnlpkrayyf wnaisilavs rfqentlsdp kkillsrlar 181 qslldlkpfq nvqeiivycl vldelfpqsr eiseeivait fanfdtsvnl ylknfilkht 241 kllnspqklf evcskliekg lddyelitnl idaayklsks kdevkqwide nlgdsrntrl 301 arlkldimyt dsvsesslsy ylskyhnkpc csidlnhysg hinidmlksi mskydpedkd 361 lihhcnilel gligsdsinn ynkfkgtlek ksvtdysscs tflleivkdk ckktnpelkd 421 vllcitilen yqakdphnfd tmcwlivlym ylglvpdayf hfinlkiknv qtdsldymif 481 srfstlfpnk qsdfysktfh ehnnlydtsl anlpryiqva fernsyskil gmlemrdklm 541 ksytrwtktl enlqfsrlcn dkrghllqkl hedwrslemt qsvsfsdnrd fsildenfaq 601 flnrgkiley anlneesifl tlireliiea lpngekteqi sallkklpsi nleellnnnl 661 tevesasfli ffeiyenngk nlhdlisrlm kvpinakqnw mvshtyltkm atlktldslk 721 rikdkeiqkl iknslkelrs ccddvfkgys kalvqayeel kkdecgnllk eldvkaenvk 781 niknsllgiq ksvrnl // LOCUS NP_014567 1294 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL075C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014567 VERSION NP_014567.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183329.2 REFERENCE 1 (residues 1 to 1294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1294) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10709. On Apr 26, 2011 this sequence version replaced NP_014567.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1294 /product="uncharacterized protein" /calculated_mol_wt="144942" Region 55..1236 /region_name="3a01205" /note="Pleiotropic Drug Resistance (PDR) Family protein; TIGR00956" /db_xref="CDD:273362" CDS 1..1294 /locus_tag="YOL075C" /coded_by="NM_001183329.2:1..3885" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23658021]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Putative ABC transporter" /db_xref="GeneID:854080" /db_xref="SGD:S000005435" ORIGIN 1 msqqengdva telienrlsf sriprislhv rdlsivaskt nttlvntfsm dlpsgsvmav 61 mggsgsgktt llnvlaskis gglthngsir yvledtgsep netepkrahl dgqdhpiqkh 121 vimaylpqqd vlsprltcre tlkfaadlkl nssertkklm veqlieelgl kdcadtlvgd 181 nshrglsgge krrlsigtqm isnpsimfld epttgldays aflviktlkk lakedgrtfi 241 msihqprsdi lflldqvcil skgnvvycdk mdntipyfes igyhvpqlvn padyfidlss 301 vdsrsdkeea atqsrlnsli dhwhdyerth lqlqaesyis nateiqiqnm ttrlpfwkqv 361 tvltrrnfkl nfsdyvtlis tfaepliigt vcgwiyykpd kssigglrtt taclyastil 421 qcylyllfdt yrlceqdial ydreraegsv tplafivark islflsddfa mtmifvsity 481 fmfgleadar kffyqfavvf lcqlscsgls mlsvavsrdf skaslvgnmt ftvlsmgcgf 541 fvnakvmpvy vrwikyiaft wysfgtlmss tftnsycttd nldeclgnqi levygfprnw 601 itvpavvllc wsvgyfvvga iilylhkidi tlqnevkskq kkikkksptg mkpeiqlldd 661 vyhqkdleae kgknihitik ledidlrvif sapfsnwkeg nfhhetkeil qsvnaifkpg 721 minaimgpsg sgkssllnli sgrlkssvfa kfdtsgsimf ndiqvselmf knvcsyvsqd 781 ddhllaaltv ketlkyaaal rlhhlteaer mertdnlirs lglkhcenni ignefvkgis 841 ggekrrvtmg vqllndppil lldeptsgld sftsatilei leklcreqgk tiiitihqpr 901 selfkrfgnv lllaksgrta fngspdemia yftelgyncp sftnvadffl dlisvntqne 961 qneissrarv ekilsawkan mdneslsptp isekqqysqe sffteysefv rkpanlvlay 1021 ivnvkrqftt trrsfdslma riaqipglgv ifalffapvk hnytsisnrl glaqestaly 1081 fvgmlgnlac ypterdyfye eyndnvygia pfflaymtle lplsalasvl yavftvlacg 1141 lprtagnffa tvycsfivtc cgealgimtn tfferpgfvv ncisiilsig tqmsglmslg 1201 msrvlkgfny lnpvgytsmi iinfafpgnl kltcedggkn sdgtcefang hdvlvsyglv 1261 rntqkylgii vcvaiiyrli affilkakle wikw // LOCUS NP_014568 322 aa linear PLN 30-JUN-2025 DEFINITION Dsc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014568 VERSION NP_014568.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183328.1 REFERENCE 1 (residues 1 to 322) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 322) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 322) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 322) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 322) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10710. Method: conceptual translation. FEATURES Location/Qualifiers source 1..322 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..322 /product="Dsc2p" /calculated_mol_wt="35631" CDS 1..322 /gene="DSC2" /locus_tag="YOL073C" /coded_by="NM_001183328.1:1..969" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0044695 Dsc E3 ubiquitin ligase complex [PMID:22681890]" /experiment="EXISTENCE:genetic interaction:GO:0140624 EGAD pathway [PMID:31368600]" /experiment="EXISTENCE:mutant phenotype:GO:0140624 EGAD pathway [PMID:31368600]" /note="Multi-transmembrane subunit of the DSC ubiquitin ligase complex; involved in the endosome and Golgi-associated degradation pathway (EGAD), contributing to proteostasis and lipid homeostasis; similar in sequence to rhomboid pseudoproteases Der1p and UBAC2 that function in ERAD; ortholog of fission yeast dsc2" /db_xref="GeneID:854081" /db_xref="SGD:S000005434" ORIGIN 1 msmeppvglt ampvtklami ttlvvplvas iasykhifll qydpflqtyh qyyrllifqf 61 cainesdtvi laliwylfrh lerllgshky ltlivlsway ttlgiwglnl iwnafigqyk 121 wlqwnnfstg slpivlslvh fykeytpqiy ewnirllgpr ggasshndnk redksavewk 181 indqfllngl illlilnqgf agilcgfisw mcgifidkgl lpgldhwrip fvsyfisqgp 241 ptranvaiaa naatntaaar atveaataat gngntgnsgp tslplrgsst tptntssagd 301 depgadepar plgvqfldtf rr // LOCUS NP_014569 455 aa linear PLN 30-JUN-2025 DEFINITION Thp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014569 VERSION NP_014569.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183327.1 REFERENCE 1 (residues 1 to 455) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 455) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 455) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 455) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10711. Method: conceptual translation. FEATURES Location/Qualifiers source 1..455 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..455 /product="Thp1p" /calculated_mol_wt="52547" Region 1..438 /region_name="COG5600" /note="Transcription-associated recombination protein [DNA replication, recombination, and repair]" /db_xref="CDD:227887" CDS 1..455 /gene="THP1" /locus_tag="YOL072W" /gene_synonym="BUD29" /coded_by="NM_001183327.1:1..1368" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:12702719]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:12702719]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11139493]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:12206772]" /experiment="EXISTENCE:direct assay:GO:0070390 transcription export complex 2 [PMID:15311284]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:11452010]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:18003937]" /experiment="EXISTENCE:mutant phenotype:GO:0006283 transcription-coupled nucleotide-excision repair [PMID:17537816]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:11139493]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:12411502]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:18614048]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:18003937]" /note="Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding" /db_xref="GeneID:854082" /db_xref="SGD:S000005433" ORIGIN 1 mdmanqllde lahgnfshlt lnlsqngrei ailqkqltgf ddkqletfve qhpampndtr 61 fkimctsfln yardvdpwsa wsssdlifef yqclinclin dnaphiemli pvatretefi 121 inlagkldsf hlqlhtrshq flshissils rlfnsikppr gnasstnipg kqrillylvn 181 klnniyfrie spqlcsnifk nfqpksmlah fneyqldqqi eyryllgryy llnsqvhnaf 241 vqfneafqsl lnlpltnqai trngtrilny miptglilgk mvkwgplrpf lsqetidnws 301 vlykhvrygn iqgvslwlrq nerhlcarql livlleklpm vtyrnliktv ikswttewgq 361 nklpyslier vlqlsigptf edpgaqeiti yngihspknv envlvtlinl gllrancfpq 421 lqlcvvkktt miqeivppvn eritkmfpah shvlw // LOCUS NP_014570 162 aa linear PLN 30-JUN-2025 DEFINITION succinate dehydrogenase assembly factor SDH5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014570 VERSION NP_014570.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183326.1 REFERENCE 1 (residues 1 to 162) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 162) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 162) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 162) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10712. Method: conceptual translation. FEATURES Location/Qualifiers source 1..162 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..162 /product="succinate dehydrogenase assembly factor SDH5" /calculated_mol_wt="18911" Region 67..144 /region_name="Sdh5" /note="Flavinator of succinate dehydrogenase; pfam03937" /db_xref="CDD:461097" CDS 1..162 /gene="SDH5" /locus_tag="YOL071W" /gene_synonym="EMI5" /coded_by="NM_001183326.1:1..489" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:19628817]" /experiment="EXISTENCE:direct assay:GO:0017013 protein flavinylation [PMID:19628817]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:12586695]" /experiment="EXISTENCE:mutant phenotype:GO:0034553 mitochondrial respiratory chain complex II assembly [PMID:23043141]" /experiment="EXISTENCE:physical interaction:GO:0006099 tricarboxylic acid cycle [PMID:19628817]" /note="Protein required for flavinylation of Sdh1p; binds to Sdh1p and promotes FAD cofactor attachment, which is necessary for succinate dehydrogenase (SDH) complex assembly and activity; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)" /db_xref="GeneID:854083" /db_xref="SGD:S000005432" ORIGIN 1 mhnmfpaltk tlslqgykii nsqtgsaaws cgrrwfssdk ddhddvvtri kiapikrtne 61 pldkkrarli yqsrkrgile tdlllsgfaa kylkkmneee leeydsllne ldwdiyywat 121 knfktsplpd kwanskllkq lqefsenkek eilsmpdlsk yq // LOCUS NP_014571 501 aa linear PLN 30-JUN-2025 DEFINITION Nba1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014571 VERSION NP_014571.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183325.1 REFERENCE 1 (residues 1 to 501) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 501) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 501) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 501) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 501) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10713. Method: conceptual translation. FEATURES Location/Qualifiers source 1..501 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..501 /product="Nba1p" /calculated_mol_wt="55792" CDS 1..501 /gene="NBA1" /locus_tag="YOL070C" /coded_by="NM_001183325.1:1..1506" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:25416945|PMID:30341817]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18086883|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:18086883|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:25416945]" /experiment="EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:30341817]" /experiment="EXISTENCE:direct assay:GO:0032177 cellular bud neck split septin rings [PMID:30341817]" /experiment="EXISTENCE:mutant phenotype:GO:0005621 cellular bud scar [PMID:29074565]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:29074565]" /experiment="EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:29074565]" /experiment="EXISTENCE:mutant phenotype:GO:1901900 regulation of protein localization to cell division site [PMID:28148650]" /note="Protein involved in axial bud site selection; prevents repolarization of cells at previous division sites; recruited by Aim44p and Nap1p to the cell cortex and to cytokinesis remnants (bud scars) where it prevents Rsr1p-mediated activation of Cdc24p, the Cdc42p GEF; localizes to the cytoplasm, and the cell division site prior to being stably recruited to cytokinesis remnants; establishes the transient localization of Rga1p, a Cdc42p GAP, at bud scars along with Nis1p; potential Cdc28p substrate" /db_xref="GeneID:854084" /db_xref="SGD:S000005431" ORIGIN 1 mseereengi sratlntqrl samidslnne kddrlfpspt ttrtmiteek adqsdvfkpp 61 srllrspagd vslppgdnrs smisnysgii qegvevsyvv knrqqtqerr tskdsnslys 121 lkepvsknel pslpmlpsea tltkhlsdnq stksntnade ivikpvtnak pvgrfnsnts 181 kkvegrgslk llssplrqek vmrssigsgn lasesgssty ntkfhqsiqe qleeeeegnv 241 sdklsivssv ipelytttne apkainpirs etndynptip prskdrprsr lfieegdgeg 301 dllteeilpt pvqpgghykn ssqistvseq ksesyysaat smppeeetyl trplpstpne 361 dsrvtsnlkr ddtlkaihdr anhtststnk qdddmyedii eetpkktklk kdtkkklnkk 421 ksvkelrsfd idtlnqllsv tkgtligsef aqlgmkieek ralerlvdsl srltadmvld 481 pdryeeglkr ldkatkaleg f // LOCUS NP_014572 451 aa linear PLN 30-JUN-2025 DEFINITION kinetochore-associated Ndc80 complex subunit NUF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014572 VERSION NP_014572.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183324.1 REFERENCE 1 (residues 1 to 451) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 451) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 451) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 451) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10714. Method: conceptual translation. FEATURES Location/Qualifiers source 1..451 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..451 /product="kinetochore-associated Ndc80 complex subunit NUF2" /calculated_mol_wt="52842" Region 5..148 /region_name="Nuf2" /note="Nuf2 family; pfam03800" /db_xref="CDD:461057" Region <144..414 /region_name="PRK03918" /note="DNA double-strand break repair ATPase Rad50" /db_xref="CDD:235175" CDS 1..451 /gene="NUF2" /locus_tag="YOL069W" /coded_by="NM_001183324.1:1..1356" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11179222|PMID:11511347]" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:11266451]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:8188751]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:11266451]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:17195848]" /experiment="EXISTENCE:direct assay:GO:0031262 Ndc80 complex [PMID:11266451]" /experiment="EXISTENCE:genetic interaction:GO:0007059 chromosome segregation [PMID:11266451]" /experiment="EXISTENCE:mutant phenotype:GO:0000776 kinetochore [PMID:11179222]" /experiment="EXISTENCE:physical interaction:GO:0031262 Ndc80 complex [PMID:11179222]" /note="Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p" /db_xref="GeneID:854085" /db_xref="SGD:S000005430" ORIGIN 1 msrnqdvfpi ldlqelvicl qscdfalatq enisrptsdy mvtlykqiie nfmgisvesl 61 lnssnqetgd ghlqeeneni yldtlnvlvl nkicfkffen igvqdfnmtd lykpeaqrtq 121 rllsavvnya rfreermfdc nsfilqmesl lgqlrskfdd ynliqqqlkq yedvdgdnip 181 deqelqklee qnkeleiqlk kltkiqetls idyndykisk qsifkdleal sfqivelesn 241 rdklikisnt dmeelsegik elndlliqrk ktlddltaqq knlqdtvttf etiiselydv 301 lriissevqe snrtetelvg lkqnlinnkl klmnvletgi mykleilqeq ldlqlknlek 361 lsqdtkeesr lndtklmdlq ikyeneikpk idktdifiqe elisgkinkl ndeikqlqkd 421 fevevkeiei eysllsghin kymnemleym q // LOCUS NP_014573 503 aa linear PLN 30-JUN-2025 DEFINITION histone deacetylase HST1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014573 VERSION NP_014573.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183323.1 REFERENCE 1 (residues 1 to 503) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 503) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 503) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 503) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 503) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10715. Method: conceptual translation. FEATURES Location/Qualifiers source 1..503 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..503 /product="histone deacetylase HST1" /EC_number="2.3.1.286" /calculated_mol_wt="57571" Region 53..207 /region_name="DUF592" /note="Protein of unknown function (DUF592); pfam04574" /db_xref="CDD:368003" Region 201..461 /region_name="SIRT1" /note="Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408" /db_xref="CDD:238699" Site order(210,212..213,220..221,272,290..291,293,310,412,417, 438..439,453) /site_type="other" /note="NAD+ binding site [chemical binding]" /db_xref="CDD:238699" Site order(292,310,384,386..390,416..418) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238699" Site order(318,321,342,345) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:238699" CDS 1..503 /gene="HST1" /locus_tag="YOL068C" /coded_by="NM_001183323.1:1..1512" /experiment="EXISTENCE:direct assay:GO:0017136 histone deacetylase activity, NAD-dependent [PMID:11313477|PMID:11711434]" /experiment="EXISTENCE:direct assay:GO:0034967 Set3 complex [PMID:11711434]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11313477|PMID:27185881]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11313477]" /experiment="EXISTENCE:mutant phenotype:GO:0045950 negative regulation of mitotic recombination [PMID:16051752]" /note="NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication" /db_xref="GeneID:854086" /db_xref="SGD:S000005429" ORIGIN 1 mnillmqriv sfilvvsqgr yfhvgeltmt mlkrpqeees dnnatkklkt rltypcilgk 61 dkvtgkfifp aitkddvmna rlflkdndlk tfleyflpve vnsiyiyfmi kllgfdvkdk 121 elfmalnsni tsnkerssae lssihakaed edeltdplek khavklikdl qkainkvlst 181 rlrlpnfnti dhftatlrna kkilvltgag vstslgipdf rssegfyski rhlgledpqd 241 vfnldiflqd psvfyniahm vlppenmysp lhsfikmlqd kgkllrnytq nidnlesyag 301 idpdklvqch gsfatascvt chwqipgeki fenirnlelp lcpycyqkrk qyfpmsngnn 361 tvqtninfns pilksygvlk pdmtffgeal psrfhktirk dilecdllic igtslkvapv 421 seivnmvpsh vpqilinrdm vthaefdlnl lgfcddvasl vakkchwdip hkkwqdlkki 481 dyncteidkg tykikkqprk kqq // LOCUS NP_014574 177 aa linear PLN 30-JUN-2025 DEFINITION Rtg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014574 VERSION NP_014574.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183322.1 REFERENCE 1 (residues 1 to 177) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 177) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 177) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 177) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10716. Method: conceptual translation. FEATURES Location/Qualifiers source 1..177 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..177 /product="Rtg1p" /calculated_mol_wt="18885" Region 16..102 /region_name="bHLHzip_USF_MITF" /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; cd11387" /db_xref="CDD:381393" Site order(17,20..24,28,80..83) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:381393" Site order(27,30,33,37,86,90,93..94,96..97,101..102) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:381393" CDS 1..177 /gene="RTG1" /locus_tag="YOL067C" /coded_by="NM_001183322.1:1..534" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:7493987|PMID:8422683]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10848632]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10848632]" /experiment="EXISTENCE:direct assay:GO:0031930 mitochondria-nucleus signaling pathway [PMID:7493987]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:7493987]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:8422683|PMID:7493987]" /experiment="EXISTENCE:mutant phenotype:GO:0031930 mitochondria-nucleus signaling pathway [PMID:8422683]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8422683|PMID:12393187]" /experiment="EXISTENCE:mutant phenotype:GO:0071400 cellular response to oleic acid [PMID:12393187]" /note="Transcription factor (bHLH) involved in interorganelle communication; contributes to communication between mitochondria, peroxisomes, and nucleus; target of Hog1p; activated in stochastic pulses of nuclear localization" /db_xref="GeneID:854087" /db_xref="SGD:S000005428" ORIGIN 1 mssipagtdp gscganfknd rkrrdkindr iqellsiipk dffrdyygns gsndtlsest 61 pgalglsska kgtgtkdgkp nkgqiltqav eyishlqnqv dtqnreevel mvkatqlakq 121 tgtivndinl entsaevals rigvgplaat nddsvrppak rlssfeyggy geygngs // LOCUS NP_014575 591 aa linear PLN 30-JUN-2025 DEFINITION bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014575 VERSION NP_014575.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183321.1 REFERENCE 1 (residues 1 to 591) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 591) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 591) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 591) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 591) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10717. Method: conceptual translation. FEATURES Location/Qualifiers source 1..591 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..591 /product="bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2" /EC_number="3.5.4.26" /EC_number="5.4.99.28" /calculated_mol_wt="66905" Region 94..406 /region_name="rluA_subfam" /note="pseudouridine synthase, RluA family; TIGR00005" /db_xref="CDD:161659" Region 459..580 /region_name="Inv-AAD" /note="Invertebrate-AID/APOBEC-deaminase; pfam18785" /db_xref="CDD:408556" CDS 1..591 /gene="RIB2" /locus_tag="YOL066C" /gene_synonym="PUS8" /coded_by="NM_001183321.1:1..1776" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:15466869]" /experiment="EXISTENCE:direct assay:GO:0031119 tRNA pseudouridine synthesis [PMID:15466869]" /experiment="EXISTENCE:mutant phenotype:GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine deaminase activity [PMID:4555411]" /experiment="EXISTENCE:mutant phenotype:GO:0009231 riboflavin biosynthetic process [PMID:4555411|PMID:5366000]" /experiment="EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:15466869]" /experiment="EXISTENCE:mutant phenotype:GO:0031119 tRNA pseudouridine synthesis [PMID:15466869]" /note="Bifunctional DRAP deaminase tRNA:pseudouridine synthase; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs; RIB2 has a paralog, PUS9, that arose from the whole genome duplication" /db_xref="GeneID:854088" /db_xref="SGD:S000005427" ORIGIN 1 medsnneasd dfnnllnkei esakevklrk fanrnnnrne nsskvkdasg frlrviqtdg 61 hktkktdpdy evtidgplrk iepyfftykt fckerwrdrk lvdvfvsefr drepsyyskt 121 iaegkvylnd epanldtiir dgdlithkvh rheppvtskp idivfededi lvidkpssip 181 vhptgryrfn titkmlerql gysvhpcnrl dkptsglmfl aktplgadrm gdqmkarevt 241 keyvarvkge fpigivevdk pvrsvnpkva lnavcemsde nakhaktvfq rvsydgqtsi 301 vkckpltgrt hqirvhlqyl gfpiandpiy snpdiwgpdl grgglqnydd ivlkldaigk 361 tnpaeswihp hsegeyllgr qceeceaemy tdpgtndldl wlhafryesl ernsdtqkpl 421 wsyrtkypew alephrryme mavkeagkcg ptktafsvga vlvhgtqvla tgysrelpgn 481 thaeqcalik ysqlhpncpt ivpmgtvlyt tmepcsfrls gnepccdril atqgaigtvf 541 vgvmepdtfv knntslnkle shgvnyiqip gyeeectiia fkghdnsddk a // LOCUS NP_014576 384 aa linear PLN 30-JUN-2025 DEFINITION phosphoinositide 5-phosphatase INP54 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014576 VERSION NP_014576.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183320.1 REFERENCE 1 (residues 1 to 384) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 384) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 384) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 384) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 384) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10718. Method: conceptual translation. FEATURES Location/Qualifiers source 1..384 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..384 /product="phosphoinositide 5-phosphatase INP54" /EC_number="3.1.3.36" /calculated_mol_wt="43668" Region 1..371 /region_name="COG5411" /note="Phosphatidylinositol 5-phosphate phosphatase [Signal transduction mechanisms]" /db_xref="CDD:227698" CDS 1..384 /gene="INP54" /locus_tag="YOL065C" /coded_by="NM_001183320.1:1..1155" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:10660045]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11116155]" /experiment="EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10660045]" /note="Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; role in secretion; localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins" /db_xref="GeneID:854089" /db_xref="SGD:S000005426" ORIGIN 1 mnktnwkvsv ttfncgkefp venskaivkq llfpyddgis qlelqdlyvl gfqevvpiwq 61 gsfpavnrdl idritttavn clnekvsatq gdeqysclgv nslgaitiiv lynnnalkvk 121 ddilkrngkc gwfgthlkgg tlisfqmtrn geenwerfsy icahlnaneg vnnrnqridd 181 ykrimsevcd sevaksdhff flgdlnfrvt stydpttnys stttlrrlle nheelnllrk 241 gedeplckgf qelkitfppt ykfklfeket yntkripswc drilyksyav ptfaqegtyh 301 svprsnallf sdhqpvnltv rlprstgtpv plslhiekyp lswssgligq igdavigycg 361 wlvtknvhyw ilgslllyll lkil // LOCUS NP_014577 357 aa linear PLN 30-JUN-2025 DEFINITION 3'(2'),5'-bisphosphate nucleotidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014577 VERSION NP_014577.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183319.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10719. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..357 /product="3'(2'),5'-bisphosphate nucleotidase" /EC_number="3.1.3.7" /calculated_mol_wt="39018" Region 2..357 /region_name="bisphos_HAL2" /note="3'(2'),5'-bisphosphate nucleotidase, HAL2 family; TIGR01330" /db_xref="CDD:273558" Site order(43,49,72..73,142..145,147..148,241,263,293..294) /site_type="active" /db_xref="CDD:238775" Site order(142,294) /site_type="other" /note="putative lithium-binding site [ion binding]" /db_xref="CDD:238775" Site order(241,267,281,290,294) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238775" CDS 1..357 /gene="MET22" /locus_tag="YOL064C" /gene_synonym="HAL2" /coded_by="NM_001183319.1:1..1074" /experiment="EXISTENCE:direct assay:GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity [PMID:7809627]" /experiment="EXISTENCE:direct assay:GO:0016078 tRNA decay [PMID:31619505]" /experiment="EXISTENCE:mutant phenotype:GO:0000103 sulfate assimilation [PMID:8910555]" /experiment="EXISTENCE:mutant phenotype:GO:0009086 methionine biosynthetic process [PMID:8393782]" /experiment="EXISTENCE:mutant phenotype:GO:0042538 hyperosmotic salinity response [PMID:8393782]" /note="Bisphosphate-3'-nucleotidase; involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway; human homolog BPNT1 complements yeast null mutant" /db_xref="GeneID:854090" /db_xref="SGD:S000005425" ORIGIN 1 malerellva tqavrkasll tkriqsevis hkdsttitkn dnspvttgdy aaqtiiinai 61 ksnfpddkvv geesssglsd afvsgilnei kandevynkn ykkddflftn dqfplksled 121 vrqiidfgny eggrkgrfwc ldpidgtkgf lrgeqfavcl alivdgvvql gcigcpnlvl 181 ssygaqdlkg hesfgyifra vrglgafysp ssdaeswtki hvrhlkdtkd mitlegvekg 241 hsshdeqtai knklnisksl hldsqakycl lalgladvyl rlpiklsyqe kiwdhaagnv 301 ivheaggiht damedvpldf gngrtlatkg viassgprel hdlvvstscd viqsrna // LOCUS NP_014578 957 aa linear PLN 30-JUN-2025 DEFINITION Crt10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014578 VERSION NP_014578.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183318.1 REFERENCE 1 (residues 1 to 957) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 957) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 957) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 957) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 957) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 957) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 957) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 957) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 957) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10720. Method: conceptual translation. FEATURES Location/Qualifiers source 1..957 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..957 /product="Crt10p" /calculated_mol_wt="109584" Region 127..948 /region_name="CRT10" /note="pfam08728" /db_xref="CDD:400874" CDS 1..957 /gene="CRT10" /locus_tag="YOL063C" /coded_by="NM_001183318.1:1..2874" /experiment="EXISTENCE:genetic interaction:GO:0070651 nonfunctional rRNA decay [PMID:25534857]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:25534857]" /note="Protein required for the degradation of mutant 25S rRNAs; functions in Mms1 pathway of nonfunctional 25S rRNA decay; expression induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat" /db_xref="GeneID:854091" /db_xref="SGD:S000005424" ORIGIN 1 mppqipnend dlftrwlksr aiiqravstr ecfdsevfla sggwnitnei itlkkyyqlk 61 wpnsscnsfh pktvefiker lhnleehdss wkipnpaysf kkafledtks afsnlepvwg 121 psrllnpael llpqdekllv qeiplefapf qytnrfaygg lqfknnlfvt ygsysflaag 181 qcvevhnfdi llnvssleic hallpviipd dgdvrnfrns syvkfkdtqf nsipelcsin 241 fmkicnfmhq dfllacgdng ivyiweinkv ikifnkftsd ilggkdnsre ryinvdpymv 301 lrveescwsv dvidingiiy iavghnkpgv tvfafdkdvk kerryirpld lpsshnvpcv 361 nfvpnskdsv gyitlsycsi fgnvvtvklk ehdctiltsf ldtqffgddl wtitpltkkd 421 fakvdnfell nlnyqdgfke smlysicrdd fllgyycdna ylsgnfgigt llnqfqvpvt 481 dlrltssagi pdeviplrft sfdrnytttg sikyeysred falilhagdl ddmndavtkn 541 tsceqhlhqw tfwedsgykh yratergfsk ykdiintfpq litpsgrnkt sqyqntsgrk 601 icepstyklt dlendiedis refnrsirnl kmdkqrqlrt skefkslssv nhipniesgn 661 flwyntdaaa dwrtlfgkdl ntvlkdpeic slqlnsteed dvnsdpenee sgssltsfqr 721 ryrdteqrah lksesqkswg fhnyvrnvkr llesavpgse dsplgyqlse mhdefffltt 781 ahrlvlmkan pliiisathh eifpldgvvt casksllqal nrinfvchik elnciavasq 841 lglisllrlt eyrgiysfrq eyilgwevqd pvnpspecrc nrnlfdapmy gadgessdty 901 cgvcdvyfpm gdicgldyty asdseelkrk gyatlyvasr gslrafkitt ehgttqq // LOCUS NP_014579 491 aa linear PLN 30-JUN-2025 DEFINITION Apm4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014579 VERSION NP_014579.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183317.1 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10721. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..491 /product="Apm4p" /calculated_mol_wt="55256" Region 1..142 /region_name="AP2_Mu_N" /note="AP-2 complex subunit mu N-terminal domain; cd14836" /db_xref="CDD:341440" Site order(1,18..19,21..22,44..48,51,53,55,57,59,73..79,81..83, 85..86,106,110..111,114..115,119..120,122..125,127, 133..134,136..138) /site_type="other" /note="AP2 beta interface [polypeptide binding]" /db_xref="CDD:341440" Region 207..490 /region_name="AP-2_Mu2_Cterm" /note="C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2; cd09251" /db_xref="CDD:271159" Site order(213..215,242,373,449,451,460..461,476..479,481) /site_type="signal peptide" /note="signal peptide binding site [polypeptide binding]" /db_xref="CDD:271159" Site order(231..232,299..304,308..309,330,332,440,442,486,488) /site_type="other" /note="AP-2 beta subunit interface [polypeptide binding]" /db_xref="CDD:271159" CDS 1..491 /gene="APM4" /locus_tag="YOL062C" /gene_synonym="AMP1" /coded_by="NM_001183317.1:1..1476" /experiment="EXISTENCE:curator inference:GO:0006886 intracellular protein transport [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:24460703]" /experiment="EXISTENCE:physical interaction:GO:0030122 AP-2 adaptor complex [PMID:10564262]" /note="Cargo-binding mu subunit of AP-2; AP-2 is a heterotetrameric endocytic cargo-binding adaptor that facilitates uptake of membrane proteins during clathrin-mediated endocytosis; Apm4p is required for AP-2 function and localization, and binds cell wall stress receptor Mid2p; AP-2 is required for cell polarity responses to pheromone, nutritional status and cell wall damage in S. cerevisiae, and for hyphal growth in C. albicans; AP-2 complex is conserved in mammals" /db_xref="GeneID:854092" /db_xref="SGD:S000005423" ORIGIN 1 misgvlvyss rgelvlnkff knslkrsisd ifrvqvinnl dvrspvltlg sttfhhirsr 61 hgdnlwlvti trsnansaai weflykldav mnayrldree alkeefmivh emldimlggn 121 gipidtelns viaqmsvkpv rnmgglldsp dgndvlssss sptssagelh fpkfltkrss 181 sflgqgdsts dfydnnkitw rpkgiihkkd evflyvneri nilvsrdgsi lksyvdgtid 241 itthlsgtpi crfglndslg mqsedekkwl aqqqrhsgsd fgnknfipka aagsvlledc 301 kfhecvsldk fnrnhiiefv ppdgsmelmk yhvrdninlp fkvtpivths trdneidyri 361 tlkslfpgkl sakdvvlhip vppstvdcki svsnghckfv peenamiwrf nkyngltent 421 lsavtvstsd ttqlnlqqwt rppislefev mmfsnsglvv ryftisgkds khravkwiky 481 iskagsyevr y // LOCUS NP_014580 496 aa linear PLN 30-JUN-2025 DEFINITION ribose phosphate diphosphokinase subunit PRS5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014580 VERSION NP_014580.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183316.1 REFERENCE 1 (residues 1 to 496) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 496) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 496) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 496) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10722. Method: conceptual translation. FEATURES Location/Qualifiers source 1..496 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..496 /product="ribose phosphate diphosphokinase subunit PRS5" /EC_number="2.7.6.1" /calculated_mol_wt="53374" Region 3..493 /region_name="PrsA" /note="Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; COG0462" /db_xref="CDD:440230" CDS 1..496 /gene="PRS5" /locus_tag="YOL061W" /coded_by="NM_001183316.1:1..1491" /experiment="EXISTENCE:direct assay:GO:0002189 ribose phosphate diphosphokinase complex [PMID:15280369]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:genetic interaction:GO:0004749 ribose phosphate diphosphokinase activity [PMID:15280369]" /experiment="EXISTENCE:genetic interaction:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:15280369]" /experiment="EXISTENCE:mutant phenotype:GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process [PMID:10212224]" /note="5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:854093" /db_xref="SGD:S000005422" ORIGIN 1 msmsnivvfg gdshpelvtk icenldihps kvelgkfsng etnialresv rekdvyiiqs 61 gcgqvndtfm qllilisack sasasrvtav mpylcysrqp dipytakgap iiskpkenyt 121 feshpgtpvs sslmtqrpga esslksldsa irstinlenp qpirtpnssa tannnfdikk 181 tlsfsripmi pggklqntsn stdagelfna qnagyklwvv qagtliahll saagadhvit 241 mdlhdpqfpg ffdipvdnly ckpiaqnyiq hripdyqdav ivspdaggak rataiadale 301 lsfalihker rsqllkgppd atltsggslp vsprplvttl vssqnttssg atgvaalemk 361 kttstsstss qssnsskfvq ttmlvgdvrn kvciivddlv dtsytitraa kllkdqgstk 421 vyalithgvf sgdalerigq ssidkliisn tvpqdrtlqy lgkdrvdvid vsciigeair 481 rihngesism lfehgw // LOCUS NP_014581 706 aa linear PLN 30-JUN-2025 DEFINITION Mam3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014581 VERSION NP_014581.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183315.1 REFERENCE 1 (residues 1 to 706) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 706) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 706) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 706) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10723. Method: conceptual translation. FEATURES Location/Qualifiers source 1..706 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..706 /product="Mam3p" /calculated_mol_wt="77581" Region 66..>388 /region_name="TlyC" /note="Hemolysin-related protein, contains CBS domains, UPF0053 family [General function prediction only]; COG1253" /db_xref="CDD:440865" CDS 1..706 /gene="MAM3" /locus_tag="YOL060C" /coded_by="NM_001183315.1:1..2121" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:10628851]" /experiment="EXISTENCE:mutant phenotype:GO:0010961 intracellular magnesium ion homeostasis [PMID:35087208]" /experiment="EXISTENCE:mutant phenotype:GO:0030026 intracellular manganese ion homeostasis [PMID:15498024]" /note="Protein involved in magnesium homeostasis; required for Mg2+ sequestration in vacuole; required for normal mitochondrial morphology; has similarity to hemolysins" /db_xref="GeneID:854094" /db_xref="SGD:S000005421" ORIGIN 1 msflplrsrs rsgaphwvyi ilyhiftipk iyslpllsgs hvlnsrdvad sghsvgdeas 61 vttyyiisii lvllggvfag ltlglmgqde vylkvistsg snsekklakr vldlisrgkh 121 wvlvtlllsn vitnetlpiv ldrclgggwq avvsstiliv ifgeiipqsv cvkyglqvga 181 ffcpfvlvlm ylmypvaypi atlldymlge dhgtmykksg lktlvtlhrt mgverltkde 241 vtiisavldl kakrveeimt pienvftmsa dtilddktve kifnsgfsri piflpnepnn 301 figmllvrvl isydpddclp ishfplatlp etspntscln ilnyfqegka hmcvvskepg 361 sshgaigvlt ledvieelig eeivdesdvf vdmhqhimrq qpgplskrhi tsylhhlyts 421 shkehkaadq adesspllsp snsnhpsehp qqdlnnkswk qksndgydrs navlsptpqv 481 tehgtiipsn lasnplnvnk sfvtikkpan vpkiitthtp hsskepspap hsndkslsae 541 eqqllsdhae lsrqavlhtq rsgqptqvtt stkttrnspd sisipnsgan hgnenqnvti 601 stsyqntkng ivesvitvkg vpktiigpak dwdeskseyg neninqensn rsddressss 661 naslfssikn kfknenannn drsnftdsls rtsnydangs sstikr // LOCUS NP_014582 440 aa linear PLN 30-JUN-2025 DEFINITION glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014582 VERSION NP_014582.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183314.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10724. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..440 /product="glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2" /EC_number="1.1.1.8" /calculated_mol_wt="49291" Region 85..432 /region_name="glycerol3P_DH" /note="glycerol-3-phosphate dehydrogenase (NAD(+)); TIGR03376" /db_xref="CDD:274551" CDS 1..440 /gene="GPD2" /locus_tag="YOL059W" /gene_synonym="GPD3" /coded_by="NM_001183314.1:1..1323" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:17054397]" /experiment="EXISTENCE:mutant phenotype:GO:0006071 glycerol metabolic process [PMID:9171333]" /experiment="EXISTENCE:mutant phenotype:GO:0047952 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity [PMID:9171333]" /note="NAD-dependent glycerol 3-phosphate dehydrogenase; expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1; GPD2 has a paralog, GPD1, that arose from the whole genome duplication" /db_xref="GeneID:854095" /db_xref="SGD:S000005420" ORIGIN 1 mlavrrltry tflkrthpvl ytrraykilp srstflrrsl lqtqlhskmt ahtnikqhkh 61 chedhpirrs dsavsivhlk rapfkvtvig sgnwgttiak viaentelhs hifepevrmw 121 vfdekigden ltdiintrhq nvkylpnidl phnlvadpdl lhsikgadil vfniphqflp 181 nivkqlqghv aphvraiscl kgfelgskgv qllssyvtde lgiqcgalsg anlapevake 241 hwsettvayq lpkdyqgdgk dvdhkilkll fhrpyfhvnv iddvagisia galknvvala 301 cgfvegmgwg nnasaaiqrl glgeiikfgr mffpeskvet yyqesagvad littcsggrn 361 vkvatymakt gksaleaeke llngqsaqgi itcrevhewl qtceltqefp lfeavyqivy 421 nnvrmedlpe mieeldidde // LOCUS NP_014583 420 aa linear PLN 30-JUN-2025 DEFINITION argininosuccinate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014583 VERSION NP_014583.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183313.2 REFERENCE 1 (residues 1 to 420) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 420) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 420) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 420) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 420) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10725. On Apr 26, 2011 this sequence version replaced NP_014583.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..420 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..420 /product="argininosuccinate synthase" /EC_number="6.3.4.5" /calculated_mol_wt="46797" Region 7..406 /region_name="Arginosuc_synth" /note="Arginosuccinate synthase; pfam00764" /db_xref="CDD:279148" CDS 1..420 /gene="ARG1" /locus_tag="YOL058W" /gene_synonym="ARG10" /coded_by="NM_001183313.2:1..1263" /experiment="EXISTENCE:direct assay:GO:0004055 argininosuccinate synthase activity [PMID:2897249]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:205532]" /experiment="EXISTENCE:mutant phenotype:GO:0006526 L-arginine biosynthetic process [PMID:2897249]" /note="Argininosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate" /db_xref="GeneID:854096" /db_xref="SGD:S000005419" ORIGIN 1 mskgkvclay sggldtsvil awlldqgyev vafmanvgqe edfdaakeka lkigackfvc 61 vdcredfvkd ilfpavqvna vyedvyllgt slarpviaka qidvakqegc favshgctgk 121 gndqirfels fyalkpdvkc itpwrmpeff erfagrkdll dyaaqkgipv aqtkakpwst 181 denqahisye agiledpdtt ppkdmwkliv dpmdapdqpq dltidfergl pvkltytdnk 241 tskevsvtkp ldvflaasnl arangvgrid ivedryinlk srgcyeqapl tvlrkahvdl 301 egltldkevr qlrdsfvtpn ysrliyngsy ftpeceyirs miqpsqnsvn gtvrvrlykg 361 nviilgrstk teklydptes smdeltgflp tdttgfiaiq airikkyges kktkgeeltl // LOCUS NP_014584 711 aa linear PLN 30-JUN-2025 DEFINITION dipeptidyl-peptidase III [Saccharomyces cerevisiae S288C]. ACCESSION NP_014584 VERSION NP_014584.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183312.1 REFERENCE 1 (residues 1 to 711) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 711) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 711) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 711) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10726. Method: conceptual translation. FEATURES Location/Qualifiers source 1..711 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..711 /product="dipeptidyl-peptidase III" /EC_number="3.4.14.4" /calculated_mol_wt="80380" Region 154..710 /region_name="Peptidase_M49" /note="Peptidase family M49; pfam03571" /db_xref="CDD:460976" CDS 1..711 /locus_tag="YOL057W" /coded_by="NM_001183312.1:1..2136" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008239 dipeptidyl-peptidase activity [PMID:19825391]" /note="Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers" /db_xref="GeneID:854097" /db_xref="SGD:S000005418" ORIGIN 1 mshffadhda plsmlsvkte yfpqltdkeq kyahfmskas hagsrvvmrq vshesepifd 61 lilaihskln gkypedditq kqqtglyley vsqflsnlgn fksfgdtkfi prcevkffkq 121 llelakinpc sspltlspvd vnheftshhl fstinelidi giyhveekaa llgfpsqgyt 181 sayylglpvt pedmallkeq lfaelailpe ntrinkvgen sfqiwvasen vknqitetyp 241 sgqitlsnav tkvefifgdh sremrlvasy lkeaqkfaan dtqkamlqey inhfvtgssq 301 ahkeaqklwv kdispvietn igfietyrep sgiigefesl vaiqnkerta kfsslvnnae 361 efisllpwsk dyekpifnpp dftslevltf tgsgipagin ipnyddvrlk igfknvslgn 421 ilsaaaksss khppsfisqe drpifekyqs dsfevqvgih ellghgsgkl lteftdgfnf 481 dkenpplgld gkpvstyykv getwgskfgq lagpfeecra eviamflltn kkildifgfh 541 dvesqdkviy agylqmarag llaleywnpk tgkwgqphmq arfsimktfm khstdknflk 601 lemnstnddf aikldkslik taghecvkdy lkhlhvykcs gdveqgskyf idrstvtpdl 661 aslrdivlsk rlprrqfiqs nsyiddnnkv tlkeydetpq gmlqsfldre l // LOCUS NP_014585 303 aa linear PLN 30-JUN-2025 DEFINITION phosphoglycerate mutase family protein GPM3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014585 VERSION NP_014585.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183311.1 REFERENCE 1 (residues 1 to 303) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 303) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 303) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 303) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10727. Method: conceptual translation. FEATURES Location/Qualifiers source 1..303 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..303 /product="phosphoglycerate mutase family protein GPM3" /EC_number="5.4.2.11" /calculated_mol_wt="34732" Region 8..284 /region_name="GpmA" /note="Phosphoglycerate mutase (BPG-dependent) [Carbohydrate transport and metabolism]; COG0588" /db_xref="CDD:440353" CDS 1..303 /gene="GPM3" /locus_tag="YOL056W" /coded_by="NM_001183311.1:1..912" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM3 has a paralog, GPM2, that arose from the whole genome duplication" /db_xref="GeneID:854098" /db_xref="SGD:S000005417" ORIGIN 1 mtvtdtfklf ilrhgqseln senifcgwid aqltekgksq arhsaklikq fcdsnnislp 61 qigytsrlir tqqtmdvile elglkhtnyv ittntnikee lqdtrfegsm pvlqtwrlne 121 rhygawqgqr kpdilkeygk ekymyirrdy ngkppkvnln lemvqeendq gsstgydfke 181 pnrhlkygpe ekanerlpes eslcevvvrl kpflnnvvls tankisqesc vivghgssvr 241 sllkvlegis dedikdvdip ngiplvield rdnysfvrkf yldpesakvn aqmvrdegfe 301 knp // LOCUS NP_014586 551 aa linear PLN 30-JUN-2025 DEFINITION trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014586 VERSION NP_014586.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183310.1 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10728. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..551 /product="trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase" /EC_number="2.7.1.49" /EC_number="2.7.4.7" /EC_number="3.5.99.2" /calculated_mol_wt="61138" Site order(25,32,34..35,37,41,44..45,48,51..56,58,61..65,70..71, 73,75..76,79,82,86..87) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238574" Site order(31,43,64,100,243) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238574" Region 33..292 /region_name="Phos_pyr_kin" /note="Phosphomethylpyrimidine kinase; pfam08543" /db_xref="CDD:430062" Site order(126,163,199,240,242) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238574" Region 343..550 /region_name="salvage_TenA" /note="thiaminase II; TIGR04306" /db_xref="CDD:213919" CDS 1..551 /gene="THI20" /locus_tag="YOL055C" /coded_by="NM_001183310.1:1..1656" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16850348]" /experiment="EXISTENCE:direct assay:GO:0008902 hydroxymethylpyrimidine kinase activity [PMID:15967475|PMID:15614489]" /experiment="EXISTENCE:direct assay:GO:0008972 phosphomethylpyrimidine kinase activity [PMID:15614489]" /experiment="EXISTENCE:direct assay:GO:0009230 thiamine catabolic process [PMID:15967475]" /experiment="EXISTENCE:direct assay:GO:0050334 thiaminase activity [PMID:15967475]" /experiment="EXISTENCE:genetic interaction:GO:0008902 hydroxymethylpyrimidine kinase activity [PMID:15614489]" /experiment="EXISTENCE:genetic interaction:GO:0008972 phosphomethylpyrimidine kinase activity [PMID:15614489|PMID:10383756]" /experiment="EXISTENCE:mutant phenotype:GO:0009228 thiamine biosynthetic process [PMID:10383756]" /note="Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity redundant with Thi21p" /db_xref="GeneID:854099" /db_xref="SGD:S000005416" ORIGIN 1 mtystvsint pppyltlacn eklptvlsia gtdpsggagi eadvktitah rcyamtcita 61 lnaqtpvkvy sinntpkevv fqtlesnlkd mkcnviktgm ltaaaievlh ekllqlgenr 121 pklvvdpvlv atsgsslagk divslitekv apfadiltpn ipecykllge erkvnglqdi 181 fqiakdlaki tkcsnilvkg ghipwndeke kyitdvlflg aeqkfiifkg nfvntththg 241 tgctlasaia snlargyslp qsvyggieyv qnavaigcdv tketvkdngp inhvyaveip 301 lekmlsdecf tasdvipkkp lksaadkipg gnfyeylinh pkvkphwdsy inhefvkkva 361 dgtlerkkfq ffieqdyayl vdyarvhcia gskapcledm ekelvivggv rtemgqhekr 421 lkevfgvkdp dyfqkikrgp alraysryfn dvsrrgnwqe lvasltpclm gygealtkmk 481 gkvtapegsv yhewcetyas swyreamdeg ekllnhilet yppeqldtlv tiyaevcele 541 tnfwtaaley e // LOCUS NP_014587 406 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein ligase PSH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014587 VERSION NP_014587.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183309.1 REFERENCE 1 (residues 1 to 406) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 406) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 406) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 406) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10729. Method: conceptual translation. FEATURES Location/Qualifiers source 1..406 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..406 /product="ubiquitin-protein ligase PSH1" /calculated_mol_wt="46937" Region 24..79 /region_name="RING-HC_ScPSH1-like" /note="RING finger, HC subclass, found in Saccharomyces cerevisiae POB3/SPT16 histone-associated protein 1 (ScPSH1) and similar proteins; cd16568" /db_xref="CDD:438230" Region 149..>175 /region_name="DNA_RNApol_7kD" /note="DNA directed RNA polymerase, 7 kDa subunit; cl00874" /db_xref="CDD:469967" CDS 1..406 /gene="PSH1" /locus_tag="YOL054W" /coded_by="NM_001183309.1:1..1221" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:21070970]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:21070971|PMID:21070970]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:21070970|PMID:21070971]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:21070970|PMID:21070971]" /note="E3 ubiquitin ligase targeting centromere-binding protein Cse4p; mediates polyubiquitination and degradation of histone H3 variant Cse4p; ubiquitination of Cse4p may be antagonized by Scm3p; interacts with the FACT complex preventing mislocalization of Cse4p to euchromatin independent of Slx5p; formyl-methionine/N-recognin component of N-end rule pathway mediating destruction of formylated cytosolic proteins elevated in response to starvation or stationary phase entry" /db_xref="GeneID:854102" /db_xref="SGD:S000005415" ORIGIN 1 mgdelhnrll hqndgtkdai lykiieslvc sichdymfvp mmtpcghnyc ygclntwfas 61 ntqkelacpq crsdittipa lnttlqqyls fileklrdqn desfkklltt ktkeendykn 121 dkekdtlfdk vfknsalava ddsddgitrc snchweldpd evedgnvcph cnarirnyag 181 grdefdeeey segeldeire smrrrrenrf astnpfanrd dvssedddss eeepmrehip 241 lgrwarshnr siavdavdde ddeeedeeee eemdsdlkdf ieddeddede dgsrrnlvls 301 alknrhviit ddeeeeqrrh ateeedrdsd fyehnddgfv sgdsldedqk evtriqsssd 361 sedrslsysg ssdvkdnndd nteelddpqp krqkrfrvvl gdsdde // LOCUS NP_014588 395 aa linear PLN 30-JUN-2025 DEFINITION Aim39p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014588 VERSION NP_014588.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183308.1 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10730. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..395 /product="Aim39p" /calculated_mol_wt="45720" CDS 1..395 /gene="AIM39" /locus_tag="YOL053W" /coded_by="NM_001183308.1:1..1188" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:35563734]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; null mutant displays elevated frequency of mitochondrial genome loss; localizes to mitochondria, cytosol and to the peroxisome in a Pex5p-dependent manner in glucose" /db_xref="GeneID:854103" /db_xref="SGD:S000005414" ORIGIN 1 mwglckkhfp snkiqvqern kalkpkksgs ehktkqlfpv fnckkkekgv mirfailrna 61 ntsllsarsi clftqaptyc hvrlntlnks ittkrnslte skrhvhdgkh ffttphqqqq 121 tklgeieegh spnikgedlr sigqaithqr nkrrkqiwsa ifggifgvil gysliyrviy 181 lkeqsflplf psskirklst rdlkkvdvnq vqklsklrvl eilsghdmik eqygvplldk 241 dgnsptlnef smwcedqdpc vtgivmepdd krdsshtwyr ipfvckwrit hrpisirgti 301 ddllnrigle tadlfeiisp ervygsfkye yplqgdshal hlwfhgeiel dddslivyng 361 kyhvdvklqe idlfrrekng qliqyvlykn eagdk // LOCUS NP_014589 61 aa linear PLN 30-JUN-2025 DEFINITION Ddr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014589 VERSION NP_014589.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183307.1 REFERENCE 1 (residues 1 to 61) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 61) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 61) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 61) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10731. Method: conceptual translation. FEATURES Location/Qualifiers source 1..61 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..61 /product="Ddr2p" /calculated_mol_wt="5824" CDS 1..61 /gene="DDR2" /locus_tag="YOL052C-A" /gene_synonym="YOL053C-A" /coded_by="NM_001183307.1:1..186" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:expression pattern:GO:0006974 DNA damage response [PMID:9473471]" /experiment="EXISTENCE:expression pattern:GO:0009267 cellular response to starvation [PMID:9473471]" /experiment="EXISTENCE:expression pattern:GO:0034605 cellular response to heat [PMID:9473471]" /experiment="EXISTENCE:expression pattern:GO:0070301 cellular response to hydrogen peroxide [PMID:9473471]" /note="Multi-stress response protein; expression is activated by a variety of xenobiotic agents and environmental or physiological stresses; DDR2 has a paralog, HOR7, that arose from the whole genome duplication" /db_xref="GeneID:854104" /db_xref="SGD:S000005413" ORIGIN 1 mkvsqvfisa isvfglatsv naqnasntts naapalhaqn gqllnagvvg aavggalafl 61 i // LOCUS NP_014590 396 aa linear PLN 30-JUN-2025 DEFINITION adenosylmethionine decarboxylase SPE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014590 VERSION NP_014590.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183306.1 REFERENCE 1 (residues 1 to 396) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 396) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 396) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 396) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10732. Method: conceptual translation. FEATURES Location/Qualifiers source 1..396 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..396 /product="adenosylmethionine decarboxylase SPE2" /EC_number="4.1.1.50" /calculated_mol_wt="46101" Region 28..396 /region_name="SAM_decarbox" /note="Adenosylmethionine decarboxylase; cl03253" /db_xref="CDD:470767" CDS 1..396 /gene="SPE2" /locus_tag="YOL052C" /coded_by="NM_001183306.1:1..1191" /experiment="EXISTENCE:direct assay:GO:0004014 adenosylmethionine decarboxylase activity [PMID:2266128]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006597 spermine biosynthetic process [PMID:7929015]" /experiment="EXISTENCE:mutant phenotype:GO:0008295 spermidine biosynthetic process [PMID:7929015]" /experiment="EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]" /note="S-adenosylmethionine decarboxylase; required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically" /db_xref="GeneID:854105" /db_xref="SGD:S000005412" ORIGIN 1 mtvtikeltn hnyidhelsa tldstdafeg peklleiwff phkksittek tlrnigmdrw 61 ieilklvkce vlsmkktkel dafllsessl fvfdhkltmk tcgttttlfc leklfqiveq 121 elswafrttq ggkykpfkvf ysrrcflfpc kqaaihqnwa devdylnkff dngksysvgr 181 ndksnhwnly vtetdrstpk gkeyieddde tfevlmteld pecaskfvcg peasttalve 241 pnedkghnlg yqmtkntrld eiyvnsaqds dlsfhhdafa ftpcgyssnm ilaekyyytl 301 hvtpekgwsy asfesnipvf disqgkqdnl dvllhilnvf qprefsmtff tknyqnqsfq 361 kllsineslp dyikldkivy dlddyhlfym klqkki // LOCUS NP_014591 1081 aa linear PLN 30-JUN-2025 DEFINITION Gal11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014591 VERSION NP_014591.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183305.1 REFERENCE 1 (residues 1 to 1081) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1081) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1081) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1081) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1081) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10733. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1081 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1081 /product="Gal11p" /calculated_mol_wt="120178" Region 9..80 /region_name="KIX_2" /note="KIX domain; pfam16987" /db_xref="CDD:465331" Region 170..232 /region_name="gal11_coact" /note="gall11 coactivator domain; cl17096" /db_xref="CDD:418417" Region 509..620 /region_name="Med15_fungi" /note="Mediator complex subunit 15; pfam05397" /db_xref="CDD:398846" CDS 1..1081 /gene="GAL11" /locus_tag="YOL051W" /gene_synonym="ABE1; MED15; RAR3; SDS4; SPT13" /coded_by="NM_001183305.1:1..3246" /experiment="EXISTENCE:direct assay:GO:0001095 TFIIE-class transcription factor complex binding [PMID:8790357]" /experiment="EXISTENCE:direct assay:GO:0001097 TFIIH-class transcription factor complex binding [PMID:10973956]" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:8378310]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8187178]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:8378310|PMID:12482986]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:20308326]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:genetic interaction:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11470794]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:15254252]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0070202 regulation of establishment of protein localization to chromosome [PMID:23447536]" /experiment="EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:18202364]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator" /db_xref="GeneID:854106" /db_xref="SGD:S000005411" ORIGIN 1 msaapvqdkd tlsnaerakn vngllqvlmd intlnggssd tadkirihak nfeaalfaks 61 sskkeymdsm nekvavmrnt yntrknavta aaannnikpv eqhhinnlkn sgnsannmnv 121 nmnlnpqmfl nqqaqarqqv aqqlrnqqqq qqqqqqqqrr qltpqqqqlv nqmkvapipk 181 qllqripnip pnintwqqvt alaqqklltp qdmeaakevy kihqqllfka rlqqqqaqaq 241 aqannnnngl pqngninnni nipqqqqmqp pnssannnpl qqqssqntvp nvlnqinqif 301 speeqrsllq eaietcknfe ktqlgstmte pvkqsfirky inqkalrkiq alrdvknnnn 361 annngsnlqr aqnvpmniiq qqqqqntnnn dtiatsatpn aaafsqqqna ssklyqmqqq 421 qqaqaqaqaq aqaqaqaqaq aqaaqaaqaq aqaqaqaqaq aqaqaqaqaq aqaqaqaqaq 481 ahaqhqpsqq pqqaqqqpnp lhgltptakd vevikqlsld asktnlrltd vtnslsneek 541 ekikmklkqg qklfvqvsnf apqvyiitkn enflkevfql rifvkeilek caegifvvkl 601 dtvdrliiky qkywesmriq ilrrqailrq qqqmannngn pgttstgnnn niatqqnmqq 661 slqqmqhlqq lkmqqqqqqq qqqqqqqqqq qqqqqqhiyp sstpgvanys amanapgnni 721 pymnhkntss mdflnsment pkvpvsaaat pslnktingk vngrtksnti pvtsipstnk 781 klsisnaasq qptprsasnt akstpntnps plktqtkngt pnpnnmktvq spmgaqpsyn 841 saiienafrk eelllkdlei rkleissrfk hrqeifkdsp mdlfmstlgd clgikdeeml 901 tsctipkavv dhingsgkrk ptkaaqrard qdsidisikd nklvmkskfn ksnrsysial 961 snvaaifkgi ggnfkdlstl vhssspstss nmdvgnprkr kasvleispq dsiasvlspd 1021 snimsdskki kvdspddpfm tksgattsek qevtneapfl tsgtsseqfn vwdwnnwtsa 1081 t // LOCUS NP_014593 491 aa linear PLN 30-JUN-2025 DEFINITION glutathione synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014593 VERSION NP_014593.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183303.1 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10734. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..491 /product="glutathione synthase" /EC_number="6.3.2.3" /calculated_mol_wt="55684" Site order(2..6,8..21,27..30,39..43) /site_type="active" /note="dimerization unit [active]" /db_xref="CDD:238140" Region 11..490 /region_name="glut_syn_euk" /note="glutathione synthetase, eukaryotic; TIGR01986" /db_xref="CDD:273912" Site order(128,151,153,228,230,234,285,288,467,478..479) /site_type="other" /note="glutathione (GSH) binding pocket [chemical binding]" /db_xref="CDD:238140" Site order(128,153,387,467) /site_type="active" /note="active site residues [active]" /db_xref="CDD:238140" Site order(132,145,324,380,382,388,391,393,415..418,442,469) /site_type="other" /note="ATP binding pocket [chemical binding]" /db_xref="CDD:238140" Site order(146,148,386) /site_type="other" /note="magnesium binding site [ion binding]" /db_xref="CDD:238140" Site 384..394 /site_type="active" /note="glycine rich loop [active]" /db_xref="CDD:238140" Site 471..483 /site_type="other" /note="alanine rich loop" /db_xref="CDD:238140" CDS 1..491 /gene="GSH2" /locus_tag="YOL049W" /coded_by="NM_001183303.1:1..1476" /experiment="EXISTENCE:direct assay:GO:0004363 glutathione synthase activity [PMID:9512666]" /experiment="EXISTENCE:mutant phenotype:GO:0006750 glutathione biosynthetic process [PMID:9512666]" /note="Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock" /db_xref="GeneID:854108" /db_xref="SGD:S000005409" ORIGIN 1 mahyppskdq lneliqevnq waitnglsmy ppkfeenpsn asvspvtiyp tpiprkcfde 61 avqiqpvfne lyaritqdma qpdsylhktt ealalsdsef tgklwslyla tlksaqykkq 121 nfrlgifrsd ylidkkkgte qikqvefntv svsfaglsek vdrlhsylnr ankydpkgpi 181 yndqnmvisd sgyllskala kavesyksqq sssttsdpiv afivqrnern vfdqkvleln 241 llekfgtksv rltfddvndk lfiddktgkl firdteqeia vvyyrtgytt tdytsekdwe 301 arlfleksfa ikapdlltql sgskkiqqll tdegvlgkyi sdaekkssll ktfvkiypld 361 dtklgregkr lalsepskyv lkpqregggn nvykenipnf lkgieerhwd ayilmeliep 421 elnenniilr dnksynepii selgiygcvl fndeqvlsne fsgsllrskf ntsneggvaa 481 gfgcldsiil y // LOCUS NP_014594 342 aa linear PLN 30-JUN-2025 DEFINITION Rrt8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014594 VERSION NP_014594.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183302.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10735. On Oct 2, 2003 this sequence version replaced NP_014594.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..342 /product="Rrt8p" /calculated_mol_wt="39469" CDS 1..342 /gene="RRT8" /locus_tag="YOL048C" /coded_by="NM_001183302.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:23966878]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:23966878]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:23966878]" /note="Protein involved in spore wall assembly; shares similarity with Lds1p and Lds2p and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854109" /db_xref="SGD:S000005408" ORIGIN 1 mkagielish sqashatyan smtlaekgpq rlkrqfkehs sskesnvsrw lkifirqfdi 61 wfpetiptmk vryellrknf ikeifnsraf iypflgfyev ltnpvywkhi llfavcyali 121 fvtiaglfyv tlvpllvtwa illlgplgvi lvhiqwilqt nvltafvcrt lvlthitnqi 181 fdislvlqdq deflnevkvl pkpqkphrki depdavrnfn tikgsrifki prllfrmffk 241 vsnftsltll slipivgpil anqlmapkrt ftylqryfll kgfskkqakd fqyehyasfi 301 cfgmsaglle lipfftivti ssntvgaakw ctsllkgerk ke // LOCUS NP_014595 356 aa linear PLN 30-JUN-2025 DEFINITION Lds2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014595 VERSION NP_014595.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183301.1 REFERENCE 1 (residues 1 to 356) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 356) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 356) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 356) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10736. On Aug 9, 2000 this sequence version replaced NP_014595.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..356 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..356 /product="Lds2p" /calculated_mol_wt="40747" CDS 1..356 /gene="LDS2" /locus_tag="YOL047C" /coded_by="NM_001183301.1:1..1071" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:23966878]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:23966878]" /experiment="EXISTENCE:direct assay:GO:0005633 ascus lipid droplet [PMID:23966878]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24390141]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:23966878]" /note="Protein Involved in spore wall assembly; localizes to lipid droplets found on or outside of the prospore membrane; shares similarity with Lds1p and Rrt8p, and a strain mutant for all 3 genes exhibits reduced dityrosine fluorescence relative to the single mutants; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" /db_xref="GeneID:854110" /db_xref="SGD:S000005407" ORIGIN 1 mstrpqpdwy yhrhpyastp laegeepqll piqdqgnhkk skiwmaykap ivrwyknaml 61 vkdnfwkdle sshqiiwypy kgisesvgns dylhlfflif gyyllnllli vaftsilaws 121 llvciylpfl glfalplaym qtilisttlc nsmvkgtdfv lftriygvtf arkgltelse 181 acetisftpf vyrrshrlgg lfskrfylvs lpqffifffw yifiafmfll lllvpivgpi 241 tinmlpfspg mgfyyfepyf vdvlhldsrk lskvyykgfa kwllysissg llesipilgg 301 lfigtnavga slwivkeikd rdqpavppsp paepeeptvg syappiqqsi ahinpp // LOCUS NP_014597 1101 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase PSK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014597 VERSION NP_014597.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183299.1 REFERENCE 1 (residues 1 to 1101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1101) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10737. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1101 /product="serine/threonine protein kinase PSK2" /EC_number="2.7.11.1" /calculated_mol_wt="124242" Region 840..1099 /region_name="STKc_PASK" /note="Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; cd14004" /db_xref="CDD:270906" Site order(847..851,855,868,870,910,926..929,936,938,975,977, 979..980,982,992..993,996,1010..1013) /site_type="active" /db_xref="CDD:270906" Site order(847..848,855,868,870,910,926..929,934,936,979..980, 982,992..993) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270906" Site order(851,936,938,975,977,979,996,1010..1013) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270906" Site 992..1013 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270906" CDS 1..1101 /gene="PSK2" /locus_tag="YOL045W" /coded_by="NM_001183299.1:1..3306" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:12372297]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:genetic interaction:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:12372297]" /experiment="EXISTENCE:genetic interaction:GO:0060917 regulation of (1->6)-beta-D-glucan biosynthetic process [PMID:17531808]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:12372297]" /experiment="EXISTENCE:mutant phenotype:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:12372297]" /experiment="EXISTENCE:mutant phenotype:GO:2000766 negative regulation of cytoplasmic translation [PMID:26310304]" /note="PAS-domain containing serine/threonine protein kinase; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation); PSK2 has a paralog, PSK1, that arose from the whole genome duplication" /db_xref="GeneID:854111" /db_xref="SGD:S000005405" ORIGIN 1 mtypvsaaap adisyskntp lvglskppcl yqhasssvds fsstfsdddr sdlvavpnes 61 phafsynpis pnslgvrlti lrrsleimvn spdilhelkk kapviaypps lrhtrnltet 121 atlsasrdpl ngslisplvs nmpspasrpv iqratslmvl pdndtaskln pakselenll 181 fllnlalenn sferasdlhm lsllnikkin fdsdiqkset lkkvlldsla epffenykkf 241 phkdlgsksq yneyeekhdd ivsladikpq qdysrilhpf tsaknsgpea iftcsqqypw 301 nfkaandlac ltfgisknvi kaltlldlih tdsrnfvlek imnaeddnqe ivftgetipi 361 vqpnstsnnn vpnliwaslw akrkngllvc vfektpcdyi dvmlnlrdfs vdsiidtthf 421 lenfdkkkqq estspmtekk tvkfaneihd igsvshslsk liddvrfgkv fsadddllpl 481 sirvanhvne eryftlncls enipcavtts vleneiklki hslpyqaglf ivdshtlsll 541 sfnksvaknm fglrlhelag ssvtklvpsl admisyinkt ypmlnitlpe nkglvltehf 601 frkieaemhh dkdsfytsig ldgchkdgnl ikvdvqlrvl ntnavllwit hsrdvvieny 661 ttvpsqlpml keneidvvgs rgsssasskk ssekipvntl kamadlsiss aetisnsdde 721 vdlnqvnekl retscgkvrg iesndnnnyd ddmtmvddpe lkhkieltkm ytqdkskfvk 781 ddnfkvdekf imriieping eeikketnel dkrnstlkat ylttpeanig sqkrikkfsd 841 ftilqvmgeg aygkvnlcih nrehyivvik mifkerilvd twvrdrklgt ipseiqimat 901 lnknsqenil klldffeddd yyyietpvhg etgsidlfdv iefkkdmveh eaklvfkqvv 961 asikhlhdqg ivhrdikden vivdshgfvk lidfgsaayi ksgpfdvfvg tmdyaapevl 1021 ggssykgkpq diwalgvlly tiiykenpyy nideilegel rfdksehvse ecislikril 1081 trevdkrpti deiyedkwlk i // LOCUS NP_014598 383 aa linear PLN 30-JUN-2025 DEFINITION Pex15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014598 VERSION NP_014598.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183298.1 REFERENCE 1 (residues 1 to 383) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 383) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 383) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 383) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 383) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10738. Method: conceptual translation. FEATURES Location/Qualifiers source 1..383 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..383 /product="Pex15p" /calculated_mol_wt="43545" CDS 1..383 /gene="PEX15" /locus_tag="YOL044W" /gene_synonym="PAS21" /coded_by="NM_001183298.1:1..1152" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:9405362]" /experiment="EXISTENCE:direct assay:GO:1904949 ATPase complex [PMID:16007078]" /experiment="EXISTENCE:direct assay:GO:1990351 transporter complex [PMID:16007078]" /experiment="EXISTENCE:genetic interaction:GO:0043495 protein-membrane adaptor activity [PMID:12808025]" /experiment="EXISTENCE:mutant phenotype:GO:0016562 protein import into peroxisome matrix, receptor recycling [PMID:16007078]" /experiment="EXISTENCE:mutant phenotype:GO:0043495 protein-membrane adaptor activity [PMID:12808025]" /experiment="EXISTENCE:physical interaction:GO:0043495 protein-membrane adaptor activity [PMID:16007078|PMID:16911527|PMID:12808025]" /note="Tail-anchored type II integral peroxisomal membrane protein; required for peroxisome biogenesis; cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol; overexpression results in impaired peroxisome assembly" /db_xref="GeneID:854113" /db_xref="SGD:S000005404" ORIGIN 1 maaseimnnl pmhsldsslr dllnddlfie sdestksvnd qrsevfqecv nlfikrdikd 61 clekmsevgf iditvfksnp mildlfvsac dimpsftklg ltlqseilni ftldtpqcie 121 trkiilgdls kllvinkffr ccikviqfnl tdhteqeekt lelesimsdf ifvyitkmrt 181 tidvvglqel ieififqvkv klhhkkpspn mywalcktlp klsptlkgly lskdvsieda 241 ilnsidnkiq kdkakskgkq rgvkqkihhf hepmlhnsse eqvkvedafn qrtstdsrlq 301 stgtaprkkn nditvlagsf wavlkhhftr svlnknglll tglllllclk kykslmaifk 361 hvpaafhtvy pqivgllkll asi // LOCUS NP_014599 380 aa linear PLN 30-JUN-2025 DEFINITION bifunctional N-glycosylase/AP lyase NTG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014599 VERSION NP_014599.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183297.1 REFERENCE 1 (residues 1 to 380) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 380) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 380) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 380) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10739. Method: conceptual translation. FEATURES Location/Qualifiers source 1..380 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..380 /product="bifunctional N-glycosylase/AP lyase NTG2" /EC_number="4.2.99.18" /calculated_mol_wt="43713" Region 149..335 /region_name="Nth" /note="Endonuclease III [Replication, recombination and repair]; COG0177" /db_xref="CDD:439947" CDS 1..380 /gene="NTG2" /locus_tag="YOL043C" /gene_synonym="SCR2" /coded_by="NM_001183297.1:1..1143" /experiment="EXISTENCE:direct assay:GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity [PMID:9020769]" /experiment="EXISTENCE:direct assay:GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity [PMID:14500818]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19029246|PMID:10471279]" /experiment="EXISTENCE:direct assay:GO:0006284 base-excision repair [PMID:14500818]" /experiment="EXISTENCE:direct assay:GO:0006285 base-excision repair, AP site formation [PMID:9826748]" /note="DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair, localizes to the nucleus; sumoylated; NTG2 has a paralog, NTG1, that arose from the whole genome duplication" /db_xref="GeneID:854114" /db_xref="SGD:S000005403" ORIGIN 1 mreesrsrkr khipvdieev evrskyfkkn ertvelvken kinkdlqnyg gvnidwikal 61 kpieyfewie srtcddprtw grpitkeemi ndsgakvpes flpiynrvrl mrskvktpvd 121 amgcsmipvl vsnkcgipse kvdpknfrlq fligtmlsaq trdermaqaa lniteyclnt 181 lkiaegitld gllkidepvl anlircvsfy trkanfikrt aqllvdnfds dipydiegil 241 slpgvgpkmg yltlqkgwgl iagicvdvhv hrlckmwnwv dpikcktaeh trkelqvwlp 301 hslwyeintv lvgfgqlicm argkrcdlcl andvcnarne kliesskfhq ledkediekv 361 yshwldtvtn gitterhkkk // LOCUS NP_014600 363 aa linear PLN 30-JUN-2025 DEFINITION RNA exonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_014600 VERSION NP_014600.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183296.1 REFERENCE 1 (residues 1 to 363) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 363) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 363) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 363) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10740. Method: conceptual translation. FEATURES Location/Qualifiers source 1..363 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..363 /product="RNA exonuclease" /calculated_mol_wt="42267" Region 1..363 /region_name="CCR4" /note="mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]; COG5239" /db_xref="CDD:227564" Site order(33,79,207,252,254,312,352..353) /site_type="active" /note="putative catalytic site [active]" /db_xref="CDD:197306" Site order(79,352) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:197306" Site order(207,254,353) /site_type="other" /note="putative phosphate binding site [ion binding]" /db_xref="CDD:197306" CDS 1..363 /gene="NGL1" /locus_tag="YOL042W" /coded_by="NM_001183296.1:1..1092" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14562095]" /note="Putative endonuclease; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:854115" /db_xref="SGD:S000005402" ORIGIN 1 mftrrfipvv qstkqnigky vrkdarftll tynmlspsym wpqvytyvae pyknwsyrhr 61 llekellntf kadimclqem tardyedywh dsigvdvnyg skfisktppk ywkkpvkdmd 121 gvsifynlak fdfisssgiy lnqllnvfnq relkylynkk vtltdgasnv igedslldvl 181 kgknqvclfv slrhketgti fvvlnthlyw kydevkltqc miimrelski ikqllpgdvk 241 gqervkilft gdlnstrdsl vvnflqgqiv shgdlnlinp mrpyldrcvy ddipkdyfvh 301 tcysgklkgi fdyvwyhdsd flltkiltgn evsdellasn qlglpnenhp sdhiplltef 361 kil // LOCUS NP_014601 459 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein NOP12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014601 VERSION NP_014601.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183295.1 REFERENCE 1 (residues 1 to 459) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 459) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 459) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 459) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10741. Method: conceptual translation. FEATURES Location/Qualifiers source 1..459 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..459 /product="rRNA-processing protein NOP12" /calculated_mol_wt="51811" Region 148..272 /region_name="RRM1_Nop12p_like" /note="RNA recognition motif 1 (RRM1) found in yeast nucleolar protein 12 (Nop12p) and similar proteins; cd12669" /db_xref="CDD:410070" Region 280..370 /region_name="RRM2_Nop12p_like" /note="RNA recognition motif 2 (RRM2) found in yeast nucleolar protein 12 (Nop12p) and similar proteins; cd12670" /db_xref="CDD:410071" CDS 1..459 /gene="NOP12" /locus_tag="YOL041C" /coded_by="NM_001183295.1:1..1380" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11452019]" /experiment="EXISTENCE:direct assay:GO:0030684 preribosome [PMID:17922018]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11452019]" /note="Nucleolar protein involved in pre-25S rRNA processing; also involved in biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p" /db_xref="GeneID:854116" /db_xref="SGD:S000005401" ORIGIN 1 mssaidnlfg nidekkiess vdklfssscg pinklevksk trtvlpdskk reraaeadqe 61 ekeaskpdvs deqteevalp kvkkakkskr ndededlear yyakllneea eaeddkptvt 121 ktdetsvplt saakkvdfke delekaertv fignilstvi tskkvykefk klfgtnpiae 181 teesgnekee esskksdnne faiesirfrs isfdealprk vafvqqkfhk srdtinayiv 241 yknksavrki csnlnavvfq dhhlrvdsva hpaphdkkrs ifvgnldfee ieeslwkhfe 301 pcgdieyvri irdsktnmgk gfayvqfkdl qsvnkallln ekpmksqkqe dentkkptkk 361 arklrvsrck nmkkgttigt gldrngltds qrtragrakk ilgkadratl gqeitieglr 421 akkgegsthl kkkkqrsatg rvtkrsiafk kaqaekskk // LOCUS NP_014602 142 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS19 RPS15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014602 VERSION NP_014602.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183294.1 REFERENCE 1 (residues 1 to 142) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 142) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 142) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 142) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 142) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10742. Method: conceptual translation. FEATURES Location/Qualifiers source 1..142 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..142 /product="40S ribosomal protein uS19 RPS15" /calculated_mol_wt="15871" Region 1..140 /region_name="PTZ00096" /note="40S ribosomal protein S15; Provisional" /db_xref="CDD:185442" CDS 1..142 /gene="RPS15" /locus_tag="YOL040C" /gene_synonym="RPS21" /coded_by="NM_001183294.1:1..429" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:15167894|PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19" /db_xref="GeneID:854117" /db_xref="SGD:S000005400" ORIGIN 1 msqavnakkr vfkthsyrgv dlekllemst edfvklapar vrrrfargmt skpagfmkkl 61 raaklaapen ekpapvrthm rnmiivpemi gsvvgiyngk afnqveirpe mlghylgefs 121 itytpvrhgr agattsrfip lk // LOCUS NP_014603 106 aa linear PLN 30-JUN-2025 DEFINITION ribosomal protein P2 RPP2A [Saccharomyces cerevisiae S288C]. ACCESSION NP_014603 VERSION NP_014603.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183293.1 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10743. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..106 /product="ribosomal protein P2 RPP2A" /calculated_mol_wt="10615" Region 15..106 /region_name="Ribosomal_P2" /note="Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins...; cd05833" /db_xref="CDD:100111" CDS 1..106 /gene="RPP2A" /locus_tag="YOL039W" /gene_synonym="RPL44; RPLA2" /coded_by="NM_001183293.1:1..321" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:22096102]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:22096102]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:1601875]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:9559554]" /note="Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm" /db_xref="GeneID:854118" /db_xref="SGD:S000005399" ORIGIN 1 mkylaaylll naagntpdat kikailesvg ieiedekvss vlsalegksv delitegnek 61 laavpaagpa saggaaaasg daaaeeekee eaaeesdddm gfglfd // LOCUS NP_878164 31 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL038C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878164 VERSION NP_878164.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184641.1 REFERENCE 1 (residues 1 to 31) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 31) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 31) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 31) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 31) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 31) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 31) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 31) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 31) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10744. Method: conceptual translation. FEATURES Location/Qualifiers source 1..31 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..31 /product="uncharacterized protein" /calculated_mol_wt="3490" CDS 1..31 /locus_tag="YOL038C-A" /coded_by="NM_001184641.1:1..96" /note="hypothetical protein; identified by SAGE analysis" /db_xref="GeneID:1466476" /db_xref="SGD:S000028812" ORIGIN 1 mkymgsflrk aattnlfnsi kkrkvqnram s // LOCUS NP_014604 254 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit alpha 4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014604 VERSION NP_014604.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183292.1 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10745. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..254 /product="proteasome core particle subunit alpha 4" /calculated_mol_wt="28308" Region 4..215 /region_name="proteasome_alpha_type_7" /note="The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming...; cd03755" /db_xref="CDD:239724" Site order(6..9,11..12,14..15,19,22,25..26,29,37,52,54..55, 79..81,83..84,115,118,121..122,125..129,148,153..154,156, 158..159,161) /site_type="other" /note="alpha subunit interaction site [polypeptide binding]" /db_xref="CDD:239724" Site order(31,47,49,63,166) /site_type="active" /db_xref="CDD:239724" CDS 1..254 /gene="PRE6" /locus_tag="YOL038W" /coded_by="NM_001183292.1:1..765" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16806052]" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019773 proteasome core complex, alpha-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:9799224]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:19029916|PMID:11545745]" /note="Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress" /db_xref="GeneID:854119" /db_xref="SGD:S000005398" ORIGIN 1 msgydralsi fspdghifqv eyaleavkrg tcavgvkgkn cvvlgcerrs tlklqdtrit 61 pskvskidsh vvlsfsglna dsriliekar veaqshrltl edpvtveylt ryvagvqqry 121 tqsggvrpfg vstliagfdp rddepklyqt epsgiyssws aqtigrnskt vrefleknyd 181 rkeppatvee cvkltvrsll evvqtgakni eitvvkpdsd ivalsseein qyvtqieqek 241 qeqqeqdkkk ksnh // LOCUS NP_014606 761 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL036W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014606 VERSION NP_014606.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183290.1 REFERENCE 1 (residues 1 to 761) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 761) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 761) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 761) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10746. Method: conceptual translation. FEATURES Location/Qualifiers source 1..761 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..761 /product="uncharacterized protein" /calculated_mol_wt="84221" CDS 1..761 /locus_tag="YOL036W" /coded_by="NM_001183290.1:1..2286" /note="hypothetical protein; potential Cdc28p substrate; YOL036W has a paralog, YIR016W, that arose from the whole genome duplication" /db_xref="GeneID:854120" /db_xref="SGD:S000005396" ORIGIN 1 mehqdssppr frnsgsnrvt vyngttlptm pksatptsss ttvtthlqni keeetnddel 61 tqvdrssprv lgrisstsss ssnidlrdnl dmlheieksn tnislsapnl heelgvlsdk 121 gnskeelall pplphtgeme itpqfdinea iferddishs srlepddvlt klanstrdat 181 gedqgfvvmt hghdastndd sqlsatildn qtsfdlskal emtshsnisn iinssgsegr 241 rsrtpvsnst lkpnlsspes aereanttss sstsdhgatm qydpkkiitp ipvlpssvre 301 qqqnnaplre rsrsnssala stlrdtiisg lpqninsver klsrksnrsr kntvtfedrl 361 qklpplstqi snqyakvapa ennialhfhn lptpvsntqt pvtfqsesgl tggekkmpfl 421 rrassallrk tsakncsnlt rtntptlsts stfesdlnar qpmlirrsst idnklprrql 481 scsklysrln sdskfanssr aseevlvstp ndtehvyrkt slgskikrgf trilsdsnns 541 keiltlspks mvttgptels fsslstvggh pttpvskend rvsidgvstf nrastslpes 601 stddisplre egkinvpkrt ssrkilskns skknvlpeqq tkpseiyldk ealqsfvpvl 661 svtegthrin rsslqtqsti glcitnlrnk egmklnakey veilaqqqrk ederyavler 721 kfascrwcsd kdlqylkkkr ismnkiwsdy vrfyrgklnn p // LOCUS NP_014608 1093 aa linear PLN 30-JUN-2025 DEFINITION DNA repair ATPase SMC5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014608 VERSION NP_014608.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183288.1 REFERENCE 1 (residues 1 to 1093) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1093) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1093) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1093) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1093) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1093) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1093) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1093) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1093) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10747. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1093 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1093 /product="DNA repair ATPase SMC5" /calculated_mol_wt="125907" Region 40..>198 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Region 42..1048 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Site 69..76 /site_type="other" /note="Walker A/P-loop" /db_xref="CDD:213244" Site 179..182 /site_type="other" /note="Q-loop/lid" /db_xref="CDD:213244" Region 739..811 /region_name="Smc5_CC_C" /note="C-terminal coiled-coil domain of Saccharomyces cerevisiae structural maintenance of chromosomes protein 5 (Smc5) and similar proteins; cd22879" /db_xref="CDD:467855" Region <956..1072 /region_name="P-loop containing Nucleoside Triphosphate Hydrolases" /note="Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a...; cl38936" /db_xref="CDD:476819" Site 986..995 /site_type="other" /note="ABC transporter signature motif" /db_xref="CDD:213244" Site 1010..1015 /site_type="other" /note="Walker B" /db_xref="CDD:213244" Site 1018..1021 /site_type="other" /note="D-loop" /db_xref="CDD:213244" Site 1045..1051 /site_type="other" /note="H-loop/switch region" /db_xref="CDD:213244" CDS 1..1093 /gene="SMC5" /locus_tag="YOL034W" /coded_by="NM_001183288.1:1..3282" /experiment="EXISTENCE:direct assay:GO:0003684 damaged DNA binding [PMID:16793545]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:21293191]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11927594]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:11927594]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:21293191]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:15738391]" /experiment="EXISTENCE:direct assay:GO:0030915 Smc5-Smc6 complex [PMID:15738391]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:15738391]" /experiment="EXISTENCE:mutant phenotype:GO:0051304 chromosome separation [PMID:15793567]" /experiment="EXISTENCE:mutant phenotype:GO:0071139 resolution of DNA recombination intermediates [PMID:20159973]" /experiment="EXISTENCE:physical interaction:GO:0000725 recombinational repair [PMID:19995966]" /note="Subunit of the SMC5-SMC6 complex; the SMC5-SMC6 complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; supports nucleolar function; S. pombe homolog forms a heterodimer with S. pombe Rad18p that is involved in DNA repair" /db_xref="GeneID:854123" /db_xref="SGD:S000005394" ORIGIN 1 mtslidlgry verthhgedt eprskrvkia kpdlssfqpg siikirlqdf vtytltefnl 61 spslnmiigp ngsgkstfvc avclglagkp eyigrskkve dfikngqdvs kieitlknsp 121 nvtdieyida rdetikitri itrskrrsdy lindyqvses vvktlvaqln iqldnlcqfl 181 sqerveefar lksvkllvet irsidaslld vldelrelqg neqslqkdld fkkakivhlr 241 qesdklrksv eslrdfqnkk geielhsqll pyvkvkdhke klniykeeye rakanlrail 301 kdkkpfantk ktlenqveel tekcslktde flkakekine ifeklntird evikkknqne 361 yyrgrtkklq atiistkedf lrsqeilaqt hlpeksvfed idikrkeiin kegeirdlis 421 eidakanain hemrsiqrqa esktkslttt dkigilnqdq dlkevrdavl mvrehpemkd 481 kileppimtv sainaqfaay laqcvdynts kaltvvdsds yklfanpild kfkvnlrels 541 sadttppvpa etvrdlgfeg ylsdfitgdk rvmkmlcqts kihtipvsrr eltpaqikkl 601 itprpngkil fkriihgnrl vdikqsaygs kqvfptdvsi kqtnfyqgsi msneqkirie 661 neiinlkney ndrkstldal snqksgyrhe lselaskndd inreahqlne irkkytmrks 721 tietlrekld qlkrearkdv sqkikdiddq iqqlllkqrh llskmassmk slkncqkeli 781 stqilqfeaq nmdvsmndvi gffnereadl ksqyedkkkf vkemrdtpef qswmreirsy 841 dqdtkeklnk vaekyeeegn fnlsfvqdvl dkleseiamv nhdesavtil dqvtaelrel 901 ehtvpqqskd letikaklke dhavlepkld divskisarf arlfnnvgsa gavrlekpkd 961 yaewkieimv kfrdnaplkk ldshtqsgge ravstvlymi alqeftsapf rvvdeinqgm 1021 dsrnerivhk amvenacaen tsqyflitpk lltglhyhek mrihcvmags wipnpsedpk 1081 mihfgetsny sfd // LOCUS NP_014609 536 aa linear PLN 30-JUN-2025 DEFINITION glutamate--tRNA ligase MSE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014609 VERSION NP_014609.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183287.1 REFERENCE 1 (residues 1 to 536) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 536) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 536) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 536) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10748. Method: conceptual translation. FEATURES Location/Qualifiers source 1..536 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..536 /product="glutamate--tRNA ligase MSE1" /EC_number="6.1.1.17" /calculated_mol_wt="61472" Region 44..533 /region_name="gltX_bact" /note="glutamyl-tRNA synthetase, bacterial family; TIGR00464" /db_xref="CDD:273092" CDS 1..536 /gene="MSE1" /locus_tag="YOL033W" /coded_by="NM_001183287.1:1..1611" /experiment="EXISTENCE:curator inference:GO:0070149 mitochondrial glutamyl-tRNA aminoacylation [PMID:7607232]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:7607232]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:7607232]" /note="Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated" /db_xref="GeneID:854124" /db_xref="SGD:S000005393" ORIGIN 1 mimlriptrs ycspsklikg vglsplkksl lskkikedih pslpvrtrfa psptgflhlg 61 slrtalynyl larntngqfl lrledtdqkr liegaeeniy eilkwcniny detpikqser 121 kliydkyvki llssgkayrc fcskerlndl rhsamelkpp smasydrcca hlgeeeiksk 181 laqgipftvr fksperyptf tdllhgqinl qpqvnfndkr yddlilvksd klptyhlanv 241 vddhlmgith virgeewlps tpkhialyna fgwacpkfih ipllttvgdk klskrkgdms 301 isdlkrqgvl pealinfcal fgwspprdla skkhecfsme eletifnlng ltkgnakvdd 361 kklwffnkhf lqkrilnpst lrelvddimp slesiyntst isrekvakil lncggslsri 421 ndfhdefyyf fekpkyndnd avtkflskne srhiahllkk lgqfqegtda qevesmvetm 481 yyengfsrkv tyqamrfala gchpgakiaa midilgikes nkrlseglqf lqrekk // LOCUS NP_014610 246 aa linear PLN 30-JUN-2025 DEFINITION Opi10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014610 VERSION NP_014610.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183286.1 REFERENCE 1 (residues 1 to 246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 246) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10749. Method: conceptual translation. FEATURES Location/Qualifiers source 1..246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..246 /product="Opi10p" /calculated_mol_wt="27036" Region 1..240 /region_name="DUF775" /note="Protein of unknown function (DUF775); pfam05603" /db_xref="CDD:461690" CDS 1..246 /gene="OPI10" /locus_tag="YOL032W" /coded_by="NM_001183286.1:1..741" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006020 inositol metabolic process [PMID:16582425]" /note="Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854125" /db_xref="SGD:S000005392" ORIGIN 1 mfaaiasgnp lqlsvevpns nglqhtivls rtkpklyshi tlfilpnvtf pqdyiatvyf 61 klspqeefkl fgylssekps aifkvqipss kkdagdtsdg lgeidmdvdd gsgaadpftd 121 tngsssnnis eliigisiep reqgmmklee wkasmnaeaq knnslilsrp nlgiirnitt 181 agqlaqvyps ltqelaakiv qhaynylsgf ldaqgnvpik rfdtwwdkfr nrlandgtfl 241 devtkn // LOCUS NP_014611 421 aa linear PLN 30-JUN-2025 DEFINITION Sil1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014611 VERSION NP_014611.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183285.1 REFERENCE 1 (residues 1 to 421) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 421) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 421) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 421) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 421) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10750. Method: conceptual translation. FEATURES Location/Qualifiers source 1..421 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..421 /product="Sil1p" /calculated_mol_wt="48144" Region 123..421 /region_name="SIL1" /note="Nucleotide exchange factor SIL1; pfam16782" /db_xref="CDD:407047" CDS 1..421 /gene="SIL1" /locus_tag="YOL031C" /gene_synonym="SLS1" /coded_by="NM_001183285.1:1..1266" /experiment="EXISTENCE:direct assay:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:10958688]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation [PMID:10958688]" /note="Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein" /db_xref="GeneID:854126" /db_xref="SGD:S000005391" ORIGIN 1 mvrilpiils alssklvast ilhssihsvp sggeiisaed lkeleisgns icvdnrcypk 61 ifeprhdwqp ilpgqelpgg ldirinmdtg lkeaklndek nvgdngshel ivssedmkas 121 pgdyefssdf kemrniidsn ptlssqdiar ledsfdrime fahdykhgyk iithefalla 181 nlslnenlpl tlrelstrvi tsclrnnppv vefinesfpn fkskimaals nlndsnhrss 241 nilikrylsi lnelpvtsed lpiystvvlq nvyernnkdk qlqikvleli skilkadmye 301 nddtnlilfk rnaenwssnl qewanefqem vqnksidelh trtffdtlyn lkkifksdit 361 inkgflnwla qqckarqsnl dnglqerdte qdsfdkklid srhlifgnpm ahriknfrde 421 l // LOCUS NP_014612 484 aa linear PLN 30-JUN-2025 DEFINITION 1,3-beta-glucanosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014612 VERSION NP_014612.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183284.1 REFERENCE 1 (residues 1 to 484) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 484) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 484) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 484) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10751. Method: conceptual translation. FEATURES Location/Qualifiers source 1..484 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..484 /product="1,3-beta-glucanosyltransferase" /calculated_mol_wt="51739" Region 30..331 /region_name="Glyco_hydro_72" /note="Glucanosyltransferase; pfam03198" /db_xref="CDD:397351" CDS 1..484 /gene="GAS5" /locus_tag="YOL030W" /coded_by="NM_001183284.1:1..1455" /experiment="EXISTENCE:curator inference:GO:0006074 (1->3)-beta-D-glucan metabolic process [PMID:10769178|PMID:17397106]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953|PMID:15781460]" /experiment="EXISTENCE:direct assay:GO:0042124 1,3-beta-glucanosyltransferase activity [PMID:17397106]" /note="1,3-beta-glucanosyltransferase; has similarity to Gas1p; localizes to the cell wall" /db_xref="GeneID:854127" /db_xref="SGD:S000005390" ORIGIN 1 mllrsltsaf vlsaglaqaa sssnsstpsi eikgnaffns esgerfyirg vdyqpggssn 61 ltdpladasv cdrdvpvlkd lgintvrvyt vdnsqdhshc mkllqengiy lildvntpts 121 aisrydpacs ynadylqnvf atidtfadyd nvlgffagne vinsvnttnt atyvkavvrd 181 mkkyikarky rqipvgysaa divanrqlaa eyfncgdead aridmfgvnd yswcgessfv 241 vsgystkmkl yqdysvpvfl sefgcnqvks srpfteieai ystqmssvfs gglvyeysne 301 tnnyglvqid gdkvtkltdf enlkneyskv snpegnggys tsnnystcpd yekgvweann 361 tlpampsaas ayftsgagsp mgtgiatqqs cdakddddee dddtssssss sssssssass 421 ssesssstsk asssspsase tsllksaasa tsssqsssks kgaagiieip lifralaely 481 nlvl // LOCUS NP_014613 201 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL029C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014613 VERSION NP_014613.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183283.1 REFERENCE 1 (residues 1 to 201) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 201) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 201) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 201) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 201) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10752. Method: conceptual translation. FEATURES Location/Qualifiers source 1..201 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..201 /product="uncharacterized protein" /calculated_mol_wt="22298" CDS 1..201 /locus_tag="YOL029C" /coded_by="NM_001183283.1:1..606" /note="hypothetical protein; separated from neighboring gene, YAP7, by frame shift and corresponds to C-terminal part of YAP7 orthologs in other species; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens" /db_xref="GeneID:854128" /db_xref="SGD:S000005389" ORIGIN 1 mkpvtccnqk nnimpslvpv ccsekkiesd akksiskccg dkeiydsenr pitkedgswi 61 pgsckqcrsd phsrnfcqsl snkcssssfs snsalspdln eqqtdvnyns iklpeicsck 121 naqmnaasda krylpisyty qkirqhmqkn ksiqeqlnpe dstsissale niasglhvrg 181 qkvelqsikd alhkmdknvl e // LOCUS NP_014614 245 aa linear PLN 30-JUN-2025 DEFINITION Yap7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014614 VERSION NP_014614.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183282.1 REFERENCE 1 (residues 1 to 245) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 245) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 245) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 245) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10753. Method: conceptual translation. FEATURES Location/Qualifiers source 1..245 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..245 /product="Yap7p" /calculated_mol_wt="27256" Region 50..66 /region_name="Hap4_Hap_bind" /note="Minimal binding motif of Hap4 for binding to Hap2/3/5; pfam10297" /db_xref="CDD:402079" Region 126..188 /region_name="bZIP_YAP" /note="Basic leucine zipper (bZIP) domain of Yeast Activator Protein (YAP) and similar proteins: a DNA-binding and dimerization domain; cd14688" /db_xref="CDD:269836" Site order(126..127,131..132,134..136,138..139,142..143, 145..146) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269836" Region 130..188 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269836" Site order(149..150,153..154,156..157,160..161,163..164,167, 170..171,174..175,178,181..182,184..185) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269836" CDS 1..245 /gene="YAP7" /locus_tag="YOL028C" /coded_by="NM_001183282.1:1..738" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:20802496]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:20802496]" /note="Transcriptional repressor of nitric oxide oxidase; basic leucine zipper (bZIP) transcription factor; neighboring gene, YOL029C, created by frame-shift at position 708, corresponds to C-terminal part of YAP7 orthologs in other species; YAP7 has a paralog, YAP5, that arose from the whole genome duplication" /db_xref="GeneID:854129" /db_xref="SGD:S000005388" ORIGIN 1 mrqrrsvvav svkpkgfklg hkqgsmstts pppsspdgnv stsgpsaikl sknwelpqrl 61 kpgrkpkskr gdasanndgs skikkvqtsn qkdqmttkdh enegakgheg ksddegngsg 121 dengvdsvek rrrqnrdaqr ayrerrttri qvleekveml hnlvddwqrk ykllesefsd 181 tkenlqksia lnnelqkalp livntpfqqq penppdnpis ilemvenfkp igavslkkgk 241 lkahc // LOCUS NP_014615 573 aa linear PLN 30-JUN-2025 DEFINITION ribosome-binding protein MDM38 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014615 VERSION NP_014615.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183281.1 REFERENCE 1 (residues 1 to 573) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 573) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 573) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 573) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10754. Method: conceptual translation. FEATURES Location/Qualifiers source 1..573 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..573 /product="ribosome-binding protein MDM38" /calculated_mol_wt="64874" Region 121..358 /region_name="LETM1_RBD" /note="LETM1-like, RBD; pfam07766" /db_xref="CDD:462258" CDS 1..573 /gene="MDM38" /locus_tag="YOL027C" /gene_synonym="MKH1" /coded_by="NM_001183281.1:1..1722" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14562095|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16476776|PMID:15138253]" /experiment="EXISTENCE:direct assay:GO:0097177 mitochondrial ribosome binding [PMID:20427570]" /experiment="EXISTENCE:genetic interaction:GO:0006813 potassium ion transport [PMID:20197279]" /experiment="EXISTENCE:genetic interaction:GO:0070131 positive regulation of mitochondrial translation [PMID:20427570]" /experiment="EXISTENCE:genetic interaction:GO:1902600 proton transmembrane transport [PMID:20197279]" /experiment="EXISTENCE:mutant phenotype:GO:0006813 potassium ion transport [PMID:15904662]" /experiment="EXISTENCE:mutant phenotype:GO:0030007 intracellular potassium ion homeostasis [PMID:15138253]" /experiment="EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:16476776]" /note="Membrane-associated mitochondrial ribosome receptor; forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; ribosome-associated protein involved in the insertion of newly synthesized proteins into the mitochondrial inner membrane; role in protein export and K+/H+ exchange; localizes to the inner mitochondrial membrane; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome" /db_xref="GeneID:854130" /db_xref="SGD:S000005387" ORIGIN 1 mlnfasrasc vtrrqaslyf vknqgprlia stipschwpl raqgvqpnyp lslrfystdk 61 sksvtkpvap tstdapakpk etlmvkvkha lkhyangtkl lgyeikvstk llikfaqgye 121 lsrrernqlr rtmgdvfrli pfsafliipf aelflpfalk lfpnllpsty esgkdkqakr 181 nklieirkkt seflhetlee snlityntie naekkqkfln ffrklysake gkimtfqhde 241 isaiaqmfkn dsvldnlsrp qlaamskfms lrpfgndnml ryqirsklkd imnddktidy 301 egveslsqee lyqacvsrgm kaygvskedl vdnlkvwlel rlrqkipsvl mvlsstftfg 361 glpkenyska fsplaekket kskyddlldl yydgilqvls sipdpvynva kldvseskss 421 aaeteaekqv aekkikteek peetaipkee atakesviat tasavtpklv vvnekaetak 481 teeisqeken aeptdsaeat eaeekktsdd nefklnvlke qeelikkeee eakqrasreh 541 vpddinldee eeaksvppip adqaaktfvi kkd // LOCUS NP_014616 113 aa linear PLN 30-JUN-2025 DEFINITION Mim1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014616 VERSION NP_014616.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183280.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10755. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..113 /product="Mim1p" /calculated_mol_wt="12626" Region 14..91 /region_name="TOM13" /note="Outer membrane protein TOM13; pfam08219" /db_xref="CDD:400499" CDS 1..113 /gene="MIM1" /locus_tag="YOL026C" /gene_synonym="TOM13" /coded_by="NM_001183280.1:1..342" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:15608614|PMID:15326197]" /experiment="EXISTENCE:mutant phenotype:GO:0045040 protein insertion into mitochondrial outer membrane [PMID:21825074|PMID:21825073]" /experiment="EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:17974559|PMID:15608614]" /experiment="EXISTENCE:physical interaction:GO:0140595 MIM complex [PMID:22467864]" /note="Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; forms a complex with Mim2p in the outer membrane that functions as cation-selective channel for translocation of positively charged precursor segments; also has a role in assembly of Tom20p into the TOM complex" /db_xref="GeneID:854131" /db_xref="SGD:S000005386" ORIGIN 1 mtevvgfwes vsddesedkd cmevqntvsa desplvqslv sfvgscsinl llpflngmml 61 gfgelfahel cwrfnwfnhr nkgykvypes rkiaalkeis spgtrgrvas kfl // LOCUS NP_014617 660 aa linear PLN 30-JUN-2025 DEFINITION Lag2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014617 VERSION NP_014617.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183279.1 REFERENCE 1 (residues 1 to 660) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 660) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 660) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 660) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 660) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 660) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 660) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 660) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 660) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10756. Method: conceptual translation. FEATURES Location/Qualifiers source 1..660 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..660 /product="Lag2p" /calculated_mol_wt="75508" CDS 1..660 /gene="LAG2" /locus_tag="YOL025W" /gene_synonym="ECM36" /coded_by="NM_001183279.1:1..1983" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:genetic interaction:GO:0031397 negative regulation of protein ubiquitination [PMID:19942853]" /experiment="EXISTENCE:mutant phenotype:GO:0031397 negative regulation of protein ubiquitination [PMID:19763088]" /note="Protein that negatively regulates the SCF E3-ubiquitin ligase; regulates by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1" /db_xref="GeneID:854133" /db_xref="SGD:S000005385" ORIGIN 1 mslhisklie qyrstkdndl kymllrqnfk indiedelap lvnelllpvl veeqdmeiln 61 lvsfqvlpdl vlsmisdpaa aqlgwvisli cdpllnqsmi hanrsfvlie tlrnvlqkie 121 nsphldyhqp vnsslefisk fivemkrhmc dvdaaqlshs lsesnmliyi eslnlllkfs 181 ffsdaaspsv mvtlpfdiln dvftiaqdys atntnesidr itekllltst qlthpvdlen 241 lcpkmkyntl aavsriwykf gpivdklftn rllpvlfppq mgeecnvedv leivhnfhpy 301 fsirrlkdnr pllsdstisq lreglfgmls ilndsltrtq nendhgsdnl idsddgfgsd 361 ndpeqqayld elvsegyden mydgdtdded addinveknd eatkditetn killifselh 421 ypqeerfsel lvelqtkiai ntslidkils kettelpthn geiadlneil nevkgnkpir 481 knvifctlah tlslqsgsel svlqlsievi dhllvknhsn nitrgeqfql iklilphlkt 541 nksfidtlka gnftqkideg vtlrtmilsl llqlfpldys mlgeilptia rysvrdkdlg 601 vrdlsfqlld qilrtyynyl igidwewykd dfyqvlqetc ikkdintnll lqfppylphd // LOCUS NP_014618 172 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL024W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014618 VERSION NP_014618.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183278.1 REFERENCE 1 (residues 1 to 172) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 172) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 172) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 172) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10757. Method: conceptual translation. FEATURES Location/Qualifiers source 1..172 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..172 /product="uncharacterized protein" /calculated_mol_wt="19979" CDS 1..172 /locus_tag="YOL024W" /coded_by="NM_001183278.1:1..519" /note="hypothetical protein; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication" /db_xref="GeneID:854134" /db_xref="SGD:S000005384" ORIGIN 1 msklssypha adfinmeepp kskeffddlc avpnllkrrf pnsrrsthyc ealnysrkkl 61 pvvlskmtlq elrhnmstff lqekdqiniy dtckvidmgd rvlletmppq prdlfeklha 121 sktnlvvqta aldeplltvk aelqsssfpq ksslflyedy kkfiyqqldm fs // LOCUS NP_014619 676 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014619 VERSION NP_014619.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183277.1 REFERENCE 1 (residues 1 to 676) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 676) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 676) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 676) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10758. Method: conceptual translation. FEATURES Location/Qualifiers source 1..676 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..676 /product="translation initiation factor 2" /calculated_mol_wt="75526" Region 63..114 /region_name="IF2_N" /note="Translation initiation factor IF-2, N-terminal region; pfam04760" /db_xref="CDD:428110" Region 143..676 /region_name="InfB" /note="Translation initiation factor IF-2, a GTPase [Translation, ribosomal structure and biogenesis]; COG0532" /db_xref="CDD:440298" CDS 1..676 /gene="IFM1" /locus_tag="YOL023W" /coded_by="NM_001183277.1:1..2031" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:12729623]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:15935987]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:12729623]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:11914276|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:1935960]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:1935960]" /note="Mitochondrial translation initiation factor 2" /db_xref="GeneID:854135" /db_xref="SGD:S000005383" ORIGIN 1 mlrrhglfwl ktcprlnvll nqsipiphll hsrdicqqrw yakgkrrnqi skkelkplnf 61 sipnyisvnk lanllncrve rlikdltalg fenitttyil skeyvelilq eynfalpnls 121 tstnldnvyd elkspvnpkl ltkrapvvti mghvdhgktt iidylrkssv vaqehggitq 181 higafqitap ksgkkitfld tpghaaflkm rerganitdi ivlvvsveds lmpqtleaik 241 haknsgnemi iaitkidrip qpkerekkie kvindlivqg ipvekiggdv qvipisaktg 301 enmdlleesi vllsevmdir aenspktiae gwiiesqvkk qvgnvatvlv kkgtlqkgki 361 licgntfcki knliddkgip ilkatpsyat evlgwkdvph vgdeviqvks eaiakkfisk 421 rqdlievqkn ssiveklnee ralakeqhln kelehentvq eheqntgpkl inyiikcdvs 481 gsaeavsesi sslgndevrc nvisssvgip tesdlkmaqi testilcfnl gnlpsevinn 541 ragikikqyn viykliedvt etltenlkpi fekkivstvd vretfdfrlk kkiiriagck 601 vnngvikkns lvqvvrgpne dvifdgkist lkhnkddvae vskghecgit fesgfegfkp 661 gdkilvyenv rvpryl // LOCUS NP_014620 408 aa linear PLN 30-JUN-2025 DEFINITION small subunit rRNA maturation protein TSR4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014620 VERSION NP_014620.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183276.2 REFERENCE 1 (residues 1 to 408) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 408) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 408) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 408) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 408) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10759. Method: conceptual translation. FEATURES Location/Qualifiers source 1..408 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..408 /product="small subunit rRNA maturation protein TSR4" /calculated_mol_wt="45863" Region 295..404 /region_name="PDCD2_C" /note="Programmed cell death protein 2, C-terminal putative domain; pfam04194" /db_xref="CDD:461221" CDS 1..408 /gene="TSR4" /locus_tag="YOL022C" /coded_by="NM_001183276.2:1..1227" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:31182640|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:31062022|PMID:31182640]" /experiment="EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:31062022]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:19806183]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:31182640|PMID:31062022]" /experiment="EXISTENCE:physical interaction:GO:0051082 unfolded protein binding [PMID:31182640]" /note="Cytoplasmic assembly chaperone for ribosomal protein Rps2p; co-translationally associates with the N-terminal extension of Rps2p to facilitate expression, solubility and ribosome assembly; released prior to the nuclear import of Rps2p; required for correct processing of 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in the S288C background but not in CEN.PK2; homologous to human PDCD2L and PDCD2" /db_xref="GeneID:854136" /db_xref="SGD:S000005382" ORIGIN 1 mskieelpps dtddhsyssk pgdvflafvd apvketddil vedsfiggep kwlhpdsepp 61 aellkcgack sadnmklllq afsplddeqm saiqqrlgin nmsyinpqdd rvlyvflcte 121 cqrkgnsvrc irgvkknknv dslsekmast slekdfqinp fdlsnnsdsk cnafssnpfg 181 gananpfgad sinsnisqsk degkkkesat vsaktarklh dlqkdkeydg nkcfksclly 241 veeetfknkk pahlqlpknl kidkealdlt gdedlekdpi kldprtekls kfldddtfqk 301 fqevvgynpl qvlrydlggk pllyaetkvd ilstvprpgy npssqrifem qlmpkmifdl 361 eevvsvdngm ewgtilvftd venympefde hgvgyveecv kvqwesrt // LOCUS NP_014621 1001 aa linear PLN 30-JUN-2025 DEFINITION exosome catalytic subunit DIS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014621 VERSION NP_014621.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183275.1 REFERENCE 1 (residues 1 to 1001) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1001) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1001) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1001) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1001) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1001) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1001) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1001) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1001) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10760. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1001 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1001 /product="exosome catalytic subunit DIS3" /calculated_mol_wt="113576" Region 25..221 /region_name="PIN_Rrp44-like" /note="VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs; cd09862" /db_xref="CDD:350211" Site order(36..40,42,44,118,122..123,129,133,149,152) /site_type="other" /note="exosome subunit interface [polypeptide binding]" /db_xref="CDD:350211" Site order(47,52,55,184) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:350211" Region 252..399 /region_name="Rrp44_CSD1" /note="Rrp44-like cold shock domain; pfam17216" /db_xref="CDD:375054" Region 421..489 /region_name="OB_Dis3" /note="Dis3-like cold-shock domain 2 (CSD2); pfam17849" /db_xref="CDD:436091" Region 531..862 /region_name="RNB" /note="RNB domain; pfam00773" /db_xref="CDD:459934" Region 912..998 /region_name="Rrp44_S1" /note="S1 domain; pfam17215" /db_xref="CDD:435792" CDS 1..1001 /gene="DIS3" /locus_tag="YOL021C" /gene_synonym="MTR17; RRP44" /coded_by="NM_001183275.1:1..3006" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:17643380]" /experiment="EXISTENCE:direct assay:GO:0000175 3'-5'-RNA exonuclease activity [PMID:17173052|PMID:17643380]" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:19046973|PMID:10465791]" /experiment="EXISTENCE:direct assay:GO:0000177 cytoplasmic exosome (RNase complex) [PMID:10465791|PMID:19046973]" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:19060886|PMID:19129231|PMID:19060898]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922|PMID:9562621]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15828860|PMID:15935758|PMID:17643380]" /experiment="EXISTENCE:genetic interaction:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15145828]" /experiment="EXISTENCE:mutant phenotype:GO:0000049 tRNA binding [PMID:17643380]" /experiment="EXISTENCE:mutant phenotype:GO:0000175 3'-5'-RNA exonuclease activity [PMID:17643380|PMID:17173052]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9390555|PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0004521 RNA endonuclease activity [PMID:19060886|PMID:19129231]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:27385342]" /experiment="EXISTENCE:mutant phenotype:GO:0016075 rRNA catabolic process [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0043628 regulatory ncRNA 3'-end processing [PMID:11352936]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:11030620]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:18940861|PMID:16431988]" /experiment="EXISTENCE:mutant phenotype:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:17643380]" /experiment="EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:15935759]" /note="Exosome core complex catalytic subunit; has both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress" /db_xref="GeneID:854138" /db_xref="SGD:S000005381" ORIGIN 1 msvpaiaprr krladglsvt qkvfvrsrng gatkivrehy lrsdipclsr sctkcpqivv 61 pdaqnelpkf ilsdsplels apigkhyvvl dtnvvlqaid llenpncffd vivpqivlde 121 vrnksypvyt rlrtlcrdsd dhkrfivfhn efsehtfver lpnetindrn drairktcqw 181 ysehlkpydi nvvlvtndrl nreaatkeve sniitkslvq yiellpnadd irdsipqmds 241 fdkdlerdtf sdftfpeyys tarvmgglkn gvlyqgniqi seynflegsv slprfskpvl 301 ivgqknlnra fngdqvivel lpqsewkaps sivldsehfd vndnpdieag ddddnnesss 361 nttvisdkqr rllakdamia qrskkiqpta kvvyiqrrsw rqyvgqlaps svdpqssstq 421 nvfvilmdkc lpkvrirtrr aaelldkriv isidswptth kyplghfvrd lgtiesaqae 481 tealllehdv eyrpfskkvl eclpaeghdw kaptklddpe avskdplltk rkdlrdklic 541 sidppgcvdi ddalhakklp ngnwevgvhi advthfvkpg taldaegaar gtsvylvdkr 601 idmlpmllgt dlcslkpyvd rfafsviwel ddsanivnvn fmksvirsre afsyeqaqlr 661 iddktqndel tmgmrallkl svklkqkrle agalnlaspe vkvhmdsets dpneveikkl 721 latnslveef mllanisvar kiydafpqta mlrrhaapps tnfeilneml ntrknmsisl 781 esskaladsl drcvdpedpy fntlvrimst rcmmaaqyfy sgaysypdfr hyglavdiyt 841 hftspirryc dvvahrqlag aigyeplslt hrdknkmdmi crninrkhrn aqfagrasie 901 yyvgqvmrnn estetgyvik vfnngivvlv pkfgveglir ldnltedpns aafdeveykl 961 tfvptnsdkp rdvyvfdkve vqvrsvmdpi tskrkaelll k // LOCUS NP_014622 592 aa linear PLN 30-JUN-2025 DEFINITION aromatic amino acid transmembrane transporter TAT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014622 VERSION NP_014622.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183274.1 REFERENCE 1 (residues 1 to 592) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 592) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 592) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 592) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 592) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10761. Method: conceptual translation. FEATURES Location/Qualifiers source 1..592 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..592 /product="aromatic amino acid transmembrane transporter TAT2" /calculated_mol_wt="65274" Region 79..556 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..592 /gene="TAT2" /locus_tag="YOL020W" /gene_synonym="HPG2; LTG3; SAB2; SCM2; TAP2" /coded_by="NM_001183274.1:1..1779" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:30660361|PMID:12810702]" /experiment="EXISTENCE:direct assay:GO:0015173 aromatic amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015801 aromatic amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:35031272]" /experiment="EXISTENCE:mutant phenotype:GO:0005300 high-affinity tryptophan transmembrane transporter activity [PMID:35031272|PMID:7523855]" /experiment="EXISTENCE:mutant phenotype:GO:0015827 tryptophan transport [PMID:35031272|PMID:7523855]" /note="High affinity tryptophan and tyrosine permease; overexpression confers FK506 and FTY720 resistance" /db_xref="GeneID:854139" /db_xref="SGD:S000005380" ORIGIN 1 mtedfissvk rsneelkerk snfgfveyks kqltsssshn snsshhdddn qhgkrnifqr 61 cvdsfkspld gsfdtsnlkr tlkprhlimi aiggsigtgl fvgsgkaiae ggplgvvigw 121 aiagsqiigt ihglgeitvr fpvvgafany gtrfldpsis fvvstiyvlq wffvlpleii 181 aaamtvqywn ssidpviwva ifyavivsin lfgvrgfgea efafstikai tvcgfiilcv 241 vlicgggpdh efigakywhd pgclangfpg vlsvlvvasy slggiemtcl asgetdpkgl 301 psaikqvfwr ilffflislt lvgflvpytn qnllggssvd nspfviaikl hhikalpsiv 361 navilisvls vgnscifass rtlcsmahqg lipwwfgyid ragrplvgim anslfgllaf 421 lvksgsmsev fnwlmaiagl atcivwlsin lshirfrlam kaqgksldel efvsavgiwg 481 saysalincl iliaqfycsl wpiggwtsgk erakiffqny lcalimlfif ivhkiyykcq 541 tgkwwgvkal kdidletdrk didieivkqe iaekkmylds rpwyvrqfhf wc // LOCUS NP_878165 50 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL019W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878165 VERSION NP_878165.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184622.1 REFERENCE 1 (residues 1 to 50) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 50) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 50) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 50) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10762. Method: conceptual translation. FEATURES Location/Qualifiers source 1..50 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..50 /product="uncharacterized protein" /calculated_mol_wt="5578" CDS 1..50 /locus_tag="YOL019W-A" /coded_by="NM_001184622.1:1..153" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466477" /db_xref="SGD:S000028707" ORIGIN 1 msntfvavef swlyaislil pcetirvawa pkrayhgtse ekrrlapadi // LOCUS NP_014623 551 aa linear PLN 30-JUN-2025 DEFINITION Tos7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014623 VERSION NP_014623.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183273.1 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10763. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..551 /product="Tos7p" /calculated_mol_wt="60770" Region 7..175 /region_name="SUR7" /note="SUR7/PalI family; pfam06687" /db_xref="CDD:399580" CDS 1..551 /gene="TOS7" /locus_tag="YOL019W" /coded_by="NM_001183273.1:1..1656" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:33002606]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:33002606|PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Protein involved in secretion and cell wall organization; localizes to plasma membrane microdomains called MCCs (membrane compartment occupied by Can1); GFP-fusion protein localizes to the cell periphery and vacuole; Sur7/PalI family transmembrane domain (TMD) containing protein; TOS7 has a paralog, DCV1, that arose from the whole genome duplication" /db_xref="GeneID:854141" /db_xref="SGD:S000005379" ORIGIN 1 mkknssvvff lvglsqfvtm afliigsita pifkqigysk ydeitygtfg yckegscska 61 synyhpdels dsdsnwklns narsilgkii fitpiaagln flgflctims vllinvlssd 121 rvgsasaimf fvnltfstlg flsasliciv vfllfyphvt wcswvlipga alsllvipli 181 fsaysrssgs rdddeteele ekgmllndpy lssksgrfdi dadseanlrg dsrtnllgdn 241 fkngtnitvv pdiishnqdp klsnittstt sdistfdkea kdmensngsg lneeeddgma 301 ydkrrststy sviesesglk ngsvsnnyvr nngsntsnni nykvplgkte isssaslass 361 dysqreviph rnpsrllndi metsfnepnd shinsmssyn dkdstltsis qrgvnpevyn 421 qmpretaagp anirpyagqp hpaplvypqq rlqpqqqqpq qqyhqynlyq rttpagpdps 481 nvilqsnpyf nvapnqvpqh rnpvpgvgfa pnplpnqspi tqgykpaykr rmqnknlpra 541 ttslnnpygf r // LOCUS NP_014624 397 aa linear PLN 30-JUN-2025 DEFINITION t-SNARE syntaxin TLG2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014624 VERSION NP_014624.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183272.1 REFERENCE 1 (residues 1 to 397) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 397) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 397) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 397) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 397) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10764. Method: conceptual translation. FEATURES Location/Qualifiers source 1..397 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..397 /product="t-SNARE syntaxin TLG2" /calculated_mol_wt="45744" Region 35..338 /region_name="COG5325" /note="t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]" /db_xref="CDD:227635" CDS 1..397 /gene="TLG2" /locus_tag="YOL018C" /coded_by="NM_001183272.1:1..1194" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:11739407]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:9565594|PMID:9427746]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11739407]" /experiment="EXISTENCE:direct assay:GO:0010008 endosome membrane [PMID:9565594]" /experiment="EXISTENCE:genetic interaction:GO:0006673 inositol phosphoceramide metabolic process [PMID:18753406]" /experiment="EXISTENCE:genetic interaction:GO:0006675 mannosyl-inositol phosphorylceramide metabolic process [PMID:18753406]" /experiment="EXISTENCE:genetic interaction:GO:0006896 Golgi to vacuole transport [PMID:18753406]" /experiment="EXISTENCE:genetic interaction:GO:0032527 protein exit from endoplasmic reticulum [PMID:18753406]" /experiment="EXISTENCE:mutant phenotype:GO:0006673 inositol phosphoceramide metabolic process [PMID:18753406]" /experiment="EXISTENCE:mutant phenotype:GO:0006675 mannosyl-inositol phosphorylceramide metabolic process [PMID:18753406]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:9427746]" /experiment="EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:22753847]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:10545112]" /experiment="EXISTENCE:physical interaction:GO:0031201 SNARE complex [PMID:10397773]" /note="Syntaxin-like t-SNARE; forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; required along with VPS45 for an early step of the constitutive CVT pathway; interactions with Vps45 prevents Tlg2p degradation, and facilitates t-SNARE complex formation; homologous to mammalian SNARE protein syntaxin 16 (Sx16)" /db_xref="GeneID:854142" /db_xref="SGD:S000005378" ORIGIN 1 mfrdrtnlfl syrrtfphni tfssgkaplg ddqdiemgty pmmnmshdis arltderknk 61 henhsdalpp ifidiaqdvd dyllevrrls eqlakvyrkn slpgfedksh dealiedlsf 121 kviqmlqkcy avmkrlktiy nsqfvdgkql sreeliildn lqkiyaekiq tesnkfrvlq 181 nnylkflnkd dlkpirnkas aentllldde eeeaarekre gldiedyskr tlqrqqqlhd 241 tsaeaylrer deeitqlarg vlevstifre mqdlvvdqgt ivdridynle ntvvelksad 301 kelnkathyq krtqkckvil lltlcvialf ffvmlkphgg gsggrnngsn kynnddnktv 361 nnshddgsnt hindeesnlp sivevtesen dalddll // LOCUS NP_014625 714 aa linear PLN 30-JUN-2025 DEFINITION Esc8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014625 VERSION NP_014625.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183271.1 REFERENCE 1 (residues 1 to 714) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 714) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 714) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 714) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 714) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10765. Method: conceptual translation. FEATURES Location/Qualifiers source 1..714 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..714 /product="Esc8p" /calculated_mol_wt="82058" CDS 1..714 /gene="ESC8" /locus_tag="YOL017W" /coded_by="NM_001183271.1:1..2145" /experiment="EXISTENCE:mutant phenotype:GO:0007062 sister chromatid cohesion [PMID:27185881]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:12399377]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:12399377]" /note="Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication" /db_xref="GeneID:854143" /db_xref="SGD:S000005377" ORIGIN 1 mteiidldlv ddfikkpmvk qqknqsskpr vkrrgqltfd dfrnikivee pvvlshnssi 61 desldaatqn tkkrekyegt cdeemktkem eanmaskysn ikthsndtnk vesisehtts 121 nnrplntlnw spniplrysd fakfmsdetv tesnwapplc tplpyagdvm kilsfivkfk 181 wvfsddllnl sfqdveigle lkvaghsakn iricqdkmnl lfcsllrllf csekradnqt 241 hrnftlkrfl slknpygklv gklrsliqew glpkewrgns dilstlnfng gglltmepld 301 riillrcmid wncsysalfh neiqrlthlk gdtgfnhqtf hasrfamcga nnildscevl 361 cslmsqklen rkkrkpsdkg klskinsqmk flkgvrksls ekvttdrlra avkineewge 421 yfanefthtp iddptvdeiy klrtsefmia riprvgdfyl ppfwignecs svntsysfnd 481 mstylnyfvk fkeegtkilp aktaqnenkc qlkliyrntp acirnlqfnd vhfaevphwf 541 evagdsnsls nfieylesls sltendtddt kkgidnlief lkifsifine tiqritaapt 601 gstegrhlrt ssqrrttvhy ssdvngdvse esenevdidv sddydseyls eentltrkge 661 drtdksfgkr elhngakdcd rncddieifs epvrqlqdns rekrslrrna rkgl // LOCUS NP_014626 447 aa linear PLN 30-JUN-2025 DEFINITION calmodulin-dependent protein kinase CMK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014626 VERSION NP_014626.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183270.1 REFERENCE 1 (residues 1 to 447) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 447) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 447) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 447) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10766. Method: conceptual translation. FEATURES Location/Qualifiers source 1..447 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..447 /product="calmodulin-dependent protein kinase CMK2" /EC_number="2.7.11.17" /calculated_mol_wt="50316" Region 46..308 /region_name="STKc_CAMK" /note="The catalytic domain of CAMK family Serine/Threonine Kinases; cd05117" /db_xref="CDD:270687" Site order(53..57,61,74,76,109,125..128,132,134,170..171,173, 175..176,178,191..192,195,210..214,216) /site_type="active" /db_xref="CDD:270687" Site order(53..56,61,74,76,109,125..128,132,175..176,178, 191..192) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270687" Site order(57,132,134,170..171,173,175,195,210..214,216) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270687" Site order(191..199,210..214) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270687" CDS 1..447 /gene="CMK2" /locus_tag="YOL016C" /coded_by="NM_001183270.1:1..1344" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004683 calcium/calmodulin-dependent protein kinase activity [PMID:2061341]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894|PMID:2061341]" /note="Calmodulin-dependent protein kinase; negative feedback controller of calcium/calcineurin signalling pathway, also has additional Crz1-independent role in promoting calcium tolerance; amino acid sequence similar to mammalian Cam Kinase II; CMK2 has a paralog, CMK1, that arose from the whole genome duplication" /db_xref="GeneID:854144" /db_xref="SGD:S000005376" ORIGIN 1 mpkesevins efhvdvqdpe rlnghpvakf inklsgqpes yvnrtnyifg rtlgagsfgv 61 vrqarklstn edvaikillk kalqgnnvql qmlyeelsil qklshpnivs fkdwfeskdk 121 fyivtqlatg gelfdrilsr gkftevdave iivqilgave ymhsknvvhr dlkpenvlyv 181 dksensplvi adfgiakqlk geedliykaa gslgyvapev ltqdghgkpc diwsigvity 241 tllcgyspfi aesvegfmee ctasrypvtf hmpywdnisi dvkrfilkal rlnpadrpta 301 tellddpwit skrvetsnil pdvkkgfslr kklrdaieiv klnnrikrlr nmyslgddgd 361 ndieenslne slldgvthsl ddlrlqsqkk ggelteeqmk lksaltkdaf vqivkaatkn 421 khkvlageee ddskktlhdd resksed // LOCUS NP_014627 586 aa linear PLN 30-JUN-2025 DEFINITION Irc10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014627 VERSION NP_014627.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183269.1 REFERENCE 1 (residues 1 to 586) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 586) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 586) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 586) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 586) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10767. Method: conceptual translation. FEATURES Location/Qualifiers source 1..586 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..586 /product="Irc10p" /calculated_mol_wt="67559" CDS 1..586 /gene="IRC10" /locus_tag="YOL015W" /coded_by="NM_001183269.1:1..1761" /experiment="EXISTENCE:direct assay:GO:0070056 prospore membrane leading edge [PMID:24390141]" /note="hypothetical protein; subunit of the leading edge protein (LEP) complex (Ssp1-Ady3-Don1-Irc10) that forms a ring-like structure at the leading edge of the prospore membrane during meiosis II; null mutant displays increased levels of spontaneous Rad52p foci" /db_xref="GeneID:854145" /db_xref="SGD:S000005375" ORIGIN 1 mfieysrlpg fesinisfsr gmlrlakftn fatykqkley frllagsnky iqrisvadfe 61 rhpdeinyiy iilisilqme ecmpvlvlcp tvywvrfhwp gkcsvnslnf tnetlksafh 121 avftpyfalm kkvlgriknn mllfaephan lnnlfvkhfh dliyksvkde ktgeailylr 181 tnvnvpnvfi ddkravfhgd gmkigkftgk flcfsfkrti rwskldsvds favttvnyrv 241 svnwektprk tflsldsdtk nlhyiskkil nkkgknatts kttkssctse nvcddktfsv 301 efplttsakt eyllrsnfsl ekinesnnpt lqeltlnrth rlyrsnfrne qsttqrkfek 361 igrtvstdsg nklltfpeqk atrdsnpfsi elthatviss desalkdttn qaiaemqrit 421 paiaktisrr tanwvcsnpa pdpygepstw sriltpnlki isesspyypv hlaspnstfs 481 rdqsvrsvvm rrssvcvekq nsffrnyehf knilsrrtik vktscprlsv dvsdnkrenl 541 sqehlilpnk srekvnrfkn clhrvaealr aakenwdqhn prnsih // LOCUS NP_014628 124 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOL014W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014628 VERSION NP_014628.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183268.1 REFERENCE 1 (residues 1 to 124) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 124) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 124) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 124) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 124) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10768. Method: conceptual translation. FEATURES Location/Qualifiers source 1..124 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..124 /product="uncharacterized protein" /calculated_mol_wt="13786" CDS 1..124 /locus_tag="YOL014W" /coded_by="NM_001183268.1:1..375" /note="hypothetical protein; mCherry fusion protein localizes to the cytosol and nucleus" /db_xref="GeneID:854146" /db_xref="SGD:S000005374" ORIGIN 1 mrphhffcgn mgvmytamsg yetedaqayw acgrayesaf atltkkvpgt tfsadmptst 61 whgvldcgys ssinvaenks spidywncgr tyarnyalsd alslkptnml qyfllvlffi 121 ciil // LOCUS NP_014630 551 aa linear PLN 30-JUN-2025 DEFINITION E3 ubiquitin-protein ligase HRD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014630 VERSION NP_014630.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183267.1 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10770. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..551 /product="E3 ubiquitin-protein ligase HRD1" /EC_number="2.3.2.27" /calculated_mol_wt="63404" Region 5..551 /region_name="HRD1" /note="HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]; COG5243" /db_xref="CDD:227568" CDS 1..551 /gene="HRD1" /locus_tag="YOL013C" /gene_synonym="DER3" /coded_by="NM_001183267.1:1..1656" /experiment="EXISTENCE:direct assay:GO:0000838 Hrd1p ubiquitin ligase ERAD-M complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex [PMID:16873066]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:11146622|PMID:11139575]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9437001|PMID:11139575]" /experiment="EXISTENCE:direct assay:GO:0030970 retrograde protein transport, ER to cytosol [PMID:27321670]" /experiment="EXISTENCE:direct assay:GO:0051865 protein autoubiquitination [PMID:27321670|PMID:31713515]" /experiment="EXISTENCE:genetic interaction:GO:0004842 ubiquitin-protein transferase activity [PMID:11146622]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:18971375]" /experiment="EXISTENCE:mutant phenotype:GO:0004842 ubiquitin-protein transferase activity [PMID:11146622]" /experiment="EXISTENCE:mutant phenotype:GO:0030968 endoplasmic reticulum unfolded protein response [PMID:22298424]" /experiment="EXISTENCE:mutant phenotype:GO:0030970 retrograde protein transport, ER to cytosol [PMID:24292014]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:11146622|PMID:22298424|PMID:17035235]" /note="Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) of misfolded proteins; upon autoubiquitination triggers retrotranslocation of misfolded proteins to cytosol for degradation; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger; likely plays a general role in targeting proteins that persistently associate with and potentially obstruct the ER-localized translocon" /db_xref="GeneID:854149" /db_xref="SGD:S000005373" ORIGIN 1 mvpenrrkql aifvvvtyll tfycvysatk tsvsflqvtl klnegfnlmv lsifillnst 61 llwqlltkll fgelrliehe hiferlpfti intlfmsslf heryfftvaf fgllllylkv 121 fhwilkdrle allqsindst tmktlifsrf sfnlvllavv dyqiitrcis siytnqksdi 181 estslyliqv meftmllidl lnlflqtcln fwefyrsqqs lsnennhivh gdptdentve 241 sdqsqpvlnd ddddddddrq ftglegkfmy ekaidvftrf lktalhlsml ipfrmpmmll 301 kdvvwdilal yqsgtslwki wrnnkqlddt lvtvtveqlq nsanddnici icmdelihsp 361 nqqtwknknk kpkrlpcghi lhlsclknwm ersqtcpicr lpvfdekgnv vqttftsnsd 421 ittqttvtds tgiatdqqgf anevdllptr ttspdirivp tqnidtlamr trststpspt 481 wytfplhktg dnsvgssrsa yeflitnsde kengipvklt ienhevnslh gdggeqiakk 541 ivipdkfiqh i // LOCUS NP_014631 134 aa linear PLN 30-JUN-2025 DEFINITION histone H2AZ [Saccharomyces cerevisiae S288C]. ACCESSION NP_014631 VERSION NP_014631.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183266.1 REFERENCE 1 (residues 1 to 134) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 134) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 134) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 134) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10771. Method: conceptual translation. FEATURES Location/Qualifiers source 1..134 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..134 /product="histone H2AZ" /calculated_mol_wt="14152" Region 7..134 /region_name="PTZ00017" /note="histone H2A; Provisional" /db_xref="CDD:185399" CDS 1..134 /gene="HTZ1" /locus_tag="YOL012C" /gene_synonym="HTA3" /coded_by="NM_001183266.1:1..405" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:11090616|PMID:11081628]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:11081628]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11081628]" /experiment="EXISTENCE:genetic interaction:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:11090616]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:21357739]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11081628]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:21357739]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:17660569]" /note="Histone variant H2A.Z; exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin; Htz1p-containing nucleosomes facilitate RNA Pol II passage by affecting correct assembly and modification status of RNA Pol II elongation complexes and by favoring efficient nucleosome remodeling" /db_xref="GeneID:854150" /db_xref="SGD:S000005372" ORIGIN 1 msgkahggkg ksgakdsgsl rsqsssarag lqfpvgrikr ylkrhatgrt rvgskaaiyl 61 tavleyltae vlelagnaak dlkvkritpr hlqlairgdd eldslirati asggvlphin 121 kalllkvekk gskk // LOCUS NP_014632 686 aa linear PLN 30-JUN-2025 DEFINITION lysophospholipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014632 VERSION NP_014632.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183265.1 REFERENCE 1 (residues 1 to 686) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 686) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 686) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 686) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 686) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10772. Method: conceptual translation. FEATURES Location/Qualifiers source 1..686 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..686 /product="lysophospholipase" /EC_number="3.1.1.5" /calculated_mol_wt="74946" Region 35..595 /region_name="cPLA2_Fungal_PLB" /note="Fungal Phospholipase B-like; cPLA2 GrpIVA homologs; catalytic domain; cd07203" /db_xref="CDD:132842" Site order(112..113,115,153,409) /site_type="active" /db_xref="CDD:132842" Site 151..155 /site_type="other" /note="nucleophile elbow" /db_xref="CDD:132842" Site order(349,378) /site_type="other" /note="flexible lid region" /db_xref="CDD:132842" CDS 1..686 /gene="PLB3" /locus_tag="YOL011W" /coded_by="NM_001183265.1:1..2061" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:10497163]" /experiment="EXISTENCE:direct assay:GO:0006660 phosphatidylserine catabolic process [PMID:10497163]" /experiment="EXISTENCE:direct assay:GO:0046488 phosphatidylinositol metabolic process [PMID:10497163]" /experiment="EXISTENCE:mutant phenotype:GO:0004622 phosphatidylcholine lysophospholipase activity [PMID:10497163]" /experiment="EXISTENCE:mutant phenotype:GO:0006660 phosphatidylserine catabolic process [PMID:10497163]" /experiment="EXISTENCE:mutant phenotype:GO:0046488 phosphatidylinositol metabolic process [PMID:10497163]" /note="Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication" /db_xref="GeneID:854151" /db_xref="SGD:S000005371" ORIGIN 1 mirplcskii isyifaisqf llaanawspt dsyvpgtvsc pddinlvrea tsisqnesaw 61 lekrnkvtsv alkdfltrat anfsdssevl sklfndgnse nlpkiavavs gggyrsmltg 121 agvlaamdnr tegayehglg gllqsttyls gasggnwlvg tlalnnwtsv qdilnnmqnd 181 dsiwdlsdsi vtpgginifk takrwdhisn aveskqnady ntsladiwgr alaynffpsl 241 nrggigltws sirdfpvfqn aempfpisva dgrypgtkvi nlnatvfefn pfemgswdps 301 lnsfanvkyl gtnvsngvpl ergkctagfd nagfimgtss tlfnqfllri nsthlpsfit 361 rlarhflkdl sqdfndiavy spnpfkdtkf ldsdyttsiv dsdslflvdg geddenvpvl 421 pliqkerdvd iifavdnsad mrlawpdgss lvhtyerqfv kqgqgmsfpy vpdtntfvnl 481 glnkkptffg cdannltdlq yipplvvylp naeysfnsnq safklsyses qrrsmiqngf 541 eiatrnnftd dpefmgcvgc aiirrkqqal nitlppecet cfknycwngt ldttplpdve 601 kdvhhsfinv nsfnssigqe eslyagssas qsssssssss ssseipsata tlekkaatns 661 gshlsgisvk fsamimltll mftgav // LOCUS NP_014633 367 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing endoribonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_014633 VERSION NP_014633.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183264.1 REFERENCE 1 (residues 1 to 367) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 367) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 367) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 367) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10773. Method: conceptual translation. FEATURES Location/Qualifiers source 1..367 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..367 /product="rRNA-processing endoribonuclease" /calculated_mol_wt="40040" Region 10..367 /region_name="18S_RNA_Rcl1p" /note="18S rRNA biogenesis protein RCL1; TIGR03400" /db_xref="CDD:274564" CDS 1..367 /gene="RCL1" /locus_tag="YOL010W" /coded_by="NM_001183264.1:1..1104" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:21849504]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10790377]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:16307926]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10790377]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10790377]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10790377]" /note="Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-like proteins but no cyclase activity detected" /db_xref="GeneID:854152" /db_xref="SGD:S000005370" ORIGIN 1 msssapkytt fqgsqnfrlr ivlatlsgkp ikiekirsgd lnpglkdyev sflrliesvt 61 ngsvieisyt gttviyrpgi ivggasthic psskpvgyfv epmlylapfs kkkfsilfkg 121 itashndagi eaikwglmpv mekfgvreca lhtlkrgspp lgggevhlvv dsliaqpitm 181 heidrpiiss itgvaystrv spslvnrmid gakkvlknlq cevnitadvw rgensgkspg 241 wgitlvaqsk qkgwsyfaed igdagsipee lgekvacqll eeisksaavg rnqlplaivy 301 mvigkedigr lrinkeqide rfiillrdik kifntevflk pvdeadnedm iatikgigft 361 ntskkia // LOCUS NP_014634 271 aa linear PLN 30-JUN-2025 DEFINITION ERMES complex subunit MDM12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014634 VERSION NP_014634.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183263.1 REFERENCE 1 (residues 1 to 271) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 271) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 271) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 271) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10774. Method: conceptual translation. FEATURES Location/Qualifiers source 1..271 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..271 /product="ERMES complex subunit MDM12" /calculated_mol_wt="30598" Region 1..265 /region_name="SMP_Mdm12" /note="synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in mitochondrial distribution and morphology protein 12 (Mdm12) and similar proteins; cd21672" /db_xref="CDD:439228" Site order(1..5,7,9,16,56,59,61,68,119,121,170,264..265) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:439228" Site order(1..6,9,47..56,58,68) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:439228" Site order(5,10,16,20,24,47,52,121,125,127,131,133,162,168,170, 175,177,179,248,252,262) /site_type="lipid-binding" /note="lipid binding site [chemical binding]" /db_xref="CDD:439228" CDS 1..271 /gene="MDM12" /locus_tag="YOL009C" /coded_by="NM_001183263.1:1..816" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:9024686]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:37366411]" /experiment="EXISTENCE:direct assay:GO:0120013 lipid transfer activity [PMID:29279306]" /experiment="EXISTENCE:genetic interaction:GO:0015914 phospholipid transport [PMID:19556461]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:9024686]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:30908556]" /experiment="EXISTENCE:mutant phenotype:GO:0015917 aminophospholipid transport [PMID:27469264]" /experiment="EXISTENCE:mutant phenotype:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:17410204]" /experiment="EXISTENCE:mutant phenotype:GO:1990456 mitochondrion-endoplasmic reticulum membrane tethering [PMID:19556461]" /experiment="EXISTENCE:physical interaction:GO:0032865 ERMES complex [PMID:17410204|PMID:13679517]" /note="Mitochondrial outer membrane protein, ERMES complex subunit; required for transmission of mitochondria to daughter cells; required for mitophagy; may influence import and assembly of outer membrane beta-barrel proteins; localizes to mitochondria-ER contact sites; ERMES complex is often co-localized with peroxisomes and with concentrated areas of pyruvate dehydrogenase" /db_xref="GeneID:854153" /db_xref="SGD:S000005369" ORIGIN 1 msfdinwstl esdnrlndli rkhlnsylqn tqlpsyvsnl rvldfdlgkv gpaitlkeit 61 dpldefydsi reeadqetee nndnkedseh icpdrtianh egpkddfeap vvmpspndiq 121 flleveykgd llvtigadlv lnypvekfmt lpvklsisdi glhslcivac lskqlflsfl 181 cdvsdpaldd nqtvldpkgp ilaatkpler isivrsmkie teigeqyqgq gsvlrsvgel 241 eqflftifkd flrkelawps winldfndgd e // LOCUS NP_014635 207 aa linear PLN 30-JUN-2025 DEFINITION ubiquinone-binding protein COQ10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014635 VERSION NP_014635.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183262.1 REFERENCE 1 (residues 1 to 207) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 207) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 207) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 207) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10775. Method: conceptual translation. FEATURES Location/Qualifiers source 1..207 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..207 /product="ubiquinone-binding protein COQ10" /calculated_mol_wt="23634" Region 46..192 /region_name="COQ10p_like" /note="Coenzyme Q-binding protein COQ10p and similar proteins; cd07813" /db_xref="CDD:176855" Site order(46,48,50,59..61,63..64,79,92,94,96,98,109,111,113, 122,124,136..137,139,141,153,155,157,159,170..174,176..178, 180..182,185) /site_type="other" /note="putative coenzyme Q binding site [chemical binding]" /db_xref="CDD:176855" CDS 1..207 /gene="COQ10" /locus_tag="YOL008W" /coded_by="NM_001183262.1:1..624" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16230336]" /experiment="EXISTENCE:direct assay:GO:0048039 ubiquinone binding [PMID:16230336]" /experiment="EXISTENCE:direct assay:GO:0140104 molecular carrier activity [PMID:16230336]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:23270816]" /note="Coenzyme Q (ubiquinone) binding protein; functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes; respiratory growth defect of the null mutant is functionally complemented by human COQ10A" /db_xref="GeneID:854154" /db_xref="SGD:S000005368" ORIGIN 1 mvliirpsqt lilfrkamlk pigryplkrn ffglsgtnht ireqryvlrk ainappstvy 61 aavsevaqyk efipycvdsf vdkrnpvdnk pliaglrvgf kqydeeficn vtckdtdhty 121 tvvaetishn lfhlliskwt imphpnrpna amvelllrfk fksriynsvs lifaktvtel 181 vmnafakray hlvrlamlkp sskegsp // LOCUS NP_014636 341 aa linear PLN 30-JUN-2025 DEFINITION Csi2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014636 VERSION NP_014636.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183261.1 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10776. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..341 /product="Csi2p" /calculated_mol_wt="37125" CDS 1..341 /gene="CSI2" /locus_tag="YOL007C" /coded_by="NM_001183261.1:1..1026" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:15282802|PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:15282802]" /note="hypothetical protein; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene" /db_xref="GeneID:854155" /db_xref="SGD:S000005367" ORIGIN 1 mrlpeisiwk villlhlfal qefqlvsaan lpslssstka adssskgsss aktttslgks 61 svtskdvsss hnvtsstkmp kittsastsl ytnsslwsnn svistssitp ssvyipvtdg 121 nkflyqahhp ngtvfiafag clgaillslt gawialniks wrsarkenkl rnlenqyqhd 181 pfyfqtnind desetsshsd dsdisekvlk nnssrmslyt lgstsvlnll nnktdandnf 241 rssmfispte ilqsdannsn twsqsnesai ydslsstpre pgatqilgkf tdstnpfnyt 301 synlspdsed rstpksnvsq gkvkkyrpps vhldqlldgk e // LOCUS NP_014637 769 aa linear PLN 30-JUN-2025 DEFINITION DNA topoisomerase 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014637 VERSION NP_014637.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183260.1 REFERENCE 1 (residues 1 to 769) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 769) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 769) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 769) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 769) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10777. Method: conceptual translation. FEATURES Location/Qualifiers source 1..769 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..769 /product="DNA topoisomerase 1" /EC_number="5.6.2.1" /calculated_mol_wt="89865" Region 143..361 /region_name="Topoisom_I_N" /note="Eukaryotic DNA topoisomerase I, DNA binding fragment; pfam02919" /db_xref="CDD:460746" Region 292..741 /region_name="TOPEUc" /note="DNA Topoisomerase I (eukaryota); smart00435" /db_xref="CDD:214661" CDS 1..769 /gene="TOP1" /locus_tag="YOL006C" /gene_synonym="MAK1; MAK17" /coded_by="NM_001183260.1:1..2310" /experiment="EXISTENCE:direct assay:GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity [PMID:6088500|PMID:6319395]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:6088500]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:6088500]" /experiment="EXISTENCE:genetic interaction:GO:0009303 rRNA transcription [PMID:2436053]" /experiment="EXISTENCE:mutant phenotype:GO:0000019 regulation of mitotic recombination [PMID:2902925]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:10082585]" /experiment="EXISTENCE:mutant phenotype:GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity [PMID:2989818|PMID:6319395]" /experiment="EXISTENCE:mutant phenotype:GO:0006265 DNA topological change [PMID:2989818]" /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:2549254]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:9199287]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:1660829]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:2840207]" /experiment="EXISTENCE:mutant phenotype:GO:0007076 mitotic chromosome condensation [PMID:8895658]" /experiment="EXISTENCE:mutant phenotype:GO:0007097 nuclear migration [PMID:8895658]" /experiment="EXISTENCE:physical interaction:GO:0005730 nucleolus [PMID:10967121]" /note="Topoisomerase I; nuclear and mitochondrial enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation" /db_xref="GeneID:854156" /db_xref="SGD:S000005366" ORIGIN 1 mtiadaskvn helssddddd vplsqtlkkr kvasmnsasl qdeaepydsd eaiskiskkk 61 tkkiktepvq ssslpsppak ksatskpkki kkedgdvkvk ttkkeeqene kkkreeeeee 121 dkkakeeeee ykwwekened dtikwvtlkh ngvifpppyq plpshiklyy dgkpvdlppq 181 aeevagffaa llesdhaknp vfqknffndf lqvlkesggp lngieikefs rcdftkmfdy 241 fqlqkeqkkq ltsqekkqir lerekfeedy kfceldgrre qvgnfkvepp dlfrgrgahp 301 ktgklkrrvn pedivlnlsk dapvppapeg hkwgeirhdn tvqwlamwre nifnsfkyvr 361 laansslkgq sdykkfekar qlksyidair rdytrnlksk vmlerqkava iylidvfalr 421 aggeksedea dtvgccslry ehvtlkppnt vifdflgkds irfyqevevd kqvfknltif 481 krppkqpghq lfdrldpsil nkylqnympg ltakvfrtyn asktmqdqld lipnkgsvae 541 kilkynaanr tvailcnhqr tvtkghaqtv ekannriqel ewqkirckra ilqldkdllk 601 kepkyfeeid dltkedeati hkriidreie kyqrkfvren dkrkfekeel lpesqlkewl 661 ekvdekkqef ekelktgeve lksswnsvek ikaqvekleq riqtssiqlk dkeensqvsl 721 gtskinyidp rlsvvfckky dvpiekiftk tlrekfkwai esvdenwrf // LOCUS NP_014638 120 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase II core subunit RPB11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014638 VERSION NP_014638.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183259.1 REFERENCE 1 (residues 1 to 120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 120) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10778. Method: conceptual translation. FEATURES Location/Qualifiers source 1..120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..120 /product="DNA-directed RNA polymerase II core subunit RPB11" /calculated_mol_wt="13484" Region 13..105 /region_name="RNAP_II_RPB11" /note="RPB11 subunit of Eukaryotic RNA polymerase II; cd06926" /db_xref="CDD:132902" Site order(19,21,35,39,41..42,44,49,52,91..92,97..99,101..105) /site_type="other" /note="RPB11 - RPB3 heterodimer interface [polypeptide binding]" /db_xref="CDD:132902" Site order(26,47,58,60..62,64..67) /site_type="other" /note="RPB11 - RPB1 interaction site [polypeptide binding]" /db_xref="CDD:132902" Site order(40,65..66) /site_type="other" /note="RPB11 - RPB2 interaction site [polypeptide binding]" /db_xref="CDD:132902" Site 57 /site_type="other" /note="RPB11 - RPB8 interaction site [polypeptide binding]" /db_xref="CDD:132902" CDS 1..120 /gene="RPB11" /locus_tag="YOL005C" /coded_by="NM_001183259.1:1..363" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:8288647]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1331084]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:17179178]" /experiment="EXISTENCE:mutant phenotype:GO:0006369 termination of RNA polymerase II transcription [PMID:16537912]" /note="RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit" /db_xref="GeneID:854157" /db_xref="SGD:S000005365" ORIGIN 1 mnapdrfelf llgegesklk idpdtkapna vvitfekedh tlgnlirael lndrkvlfaa 61 ykvehpffar fklriqtteg ydpkdalkna cnsiinklga lktnfetewn lqtlaaddaf // LOCUS NP_014639 1536 aa linear PLN 30-JUN-2025 DEFINITION transcriptional regulator SIN3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014639 VERSION NP_014639.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183258.1 REFERENCE 1 (residues 1 to 1536) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1536) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1536) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1536) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10779. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1536 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1536 /product="transcriptional regulator SIN3" /calculated_mol_wt="174709" Region 75..1493 /region_name="Sin3" /note="Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]; COG5602" /db_xref="CDD:227889" CDS 1..1536 /gene="SIN3" /locus_tag="YOL004W" /gene_synonym="CPE1; GAM2; RPD1; SDI1; SDS16; UME4" /coded_by="NM_001183258.1:1..4611" /experiment="EXISTENCE:direct assay:GO:0032221 Rpd3S complex [PMID:16286007|PMID:16286008]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286008|PMID:19040720|PMID:16314178|PMID:16286007]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0070822 Sin3-type complex [PMID:9234741]" /experiment="EXISTENCE:genetic interaction:GO:0000086 G2/M transition of mitotic cell cycle [PMID:17908798]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:17908798]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17158929|PMID:2690066|PMID:11095743]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:14737171]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:9150136]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:14711989]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19270272]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:15143171]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:31553911]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11095743|PMID:14737171|PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:17158929]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:10388812]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:10388812|PMID:10082585]" /experiment="EXISTENCE:mutant phenotype:GO:0070550 rDNA chromatin condensation [PMID:31553911]" /experiment="EXISTENCE:physical interaction:GO:0003714 transcription corepressor activity [PMID:9150136]" /note="Component of both the Rpd3S and Rpd3L histone deacetylase complexes; involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity" /db_xref="GeneID:854158" /db_xref="SGD:S000005364" ORIGIN 1 msqvwhnsns qsndvatsnd atgsnernek epslqgnkpg fvqqqqritl pslsalstke 61 edrrdsngqq altshaahil gyppphsnam psiatdsalk qpheyhprpk ssssspsina 121 slmnagpapl ptvgaasfsl srfdnplpik apvhteepks ynglqeeeka tqrpqdckev 181 pagvqpadap dpssnhadan ddnnnnensh dedadyrpln vkdalsyleq vkfqfssrpd 241 iynlfldimk dfksqaidtp gviervstlf rgypiliqgf ntflpqgyri ecssnpddpi 301 rvttpmgttt vnnnispsgr gttdaqelgs fpesdgngvq qpsnvpmvps svyqseqnqd 361 qqqslpllat ssglpsiqqp empahrqipq sqslvpqeda kknvdvefsq aisyvnkikt 421 rfadqpdiyk hfleilqtyq reqkpinevy aqvthlfqna pdlledfkkf lpdssasanq 481 qvqhaqqhaq qqheaqmhaq aqaqaqaqaq veqqkqqqqf lypasgyygh psnrgipqqn 541 lppigsfspp tngstvheay qdqqhmqpph fmplpsivqh gpnmvhqgia nenpplsdlr 601 tslteqyaps siqhqqqhpq sispiantqy gdipvrpeid ldpsivpvvp eptepienni 661 slneevtffe kakryignkh lyteflkiln lysqdildld dlvekvdfyl gsnkelftwf 721 knfvgyqekt kcienivhek hrldldlcea fgpsykrlpk sdtfmpcsgr ddmcwevlnd 781 ewvghpvwas edsgfiahrk nqyeetlfki eeerheydfy iesnlrtiqc letivnkien 841 mtenekanfk lppglghtsm tiykkvirkv ydkergfeii dalhehpavt apvvlkrlkq 901 kdeewrraqr ewnkvwrele qkvffksldh lgltfkqadk kllttkqlis eissikvdqt 961 nkkihwltpk pksqldfdfp dknifydilc ladtfithtt aysnpdkerl kdllkyfisl 1021 ffsisfekie eslyshkqnv sessgsddgs siasrkrpyq qemslldilh rsryqklkrs 1081 ndedgkvpql seppeeepnt ieeeelidee aknpwltgnl veeansqgii qnrsifnlfa 1141 ntniyiffrh wttiyerlle ikqmnervtk eintrstvtf akdldllssq lsemgldfvg 1201 edaykqvlrl srrlingdle hqwfeeslrq aynnkafkly tidkvtqslv khahtlmtda 1261 ktaeimalfv kdrnasttsa kdqiiyrlqv rshmsntenm friefdkrtl hvsiqyiald 1321 dltlkepkad edkwkyyvts yalphptegi pheklkipfl erliefgqdi dgtevdeefs 1381 pegisvstlk ikiqpityql hiengsydvf trkatnkypt iandntqkgm vsqkkelisk 1441 fldcavglrn nldeaqklsm qkkwenlkds iaktsagnqg iesetekgki tkqeqsdnld 1501 sstasvlpas ittvpqddni ettgntessd kgakiq // LOCUS NP_014640 378 aa linear PLN 30-JUN-2025 DEFINITION palmitoyltransferase PFA4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014640 VERSION NP_014640.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183257.1 REFERENCE 1 (residues 1 to 378) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 378) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 378) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 378) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10780. Method: conceptual translation. FEATURES Location/Qualifiers source 1..378 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..378 /product="palmitoyltransferase PFA4" /EC_number="2.3.1.225" /calculated_mol_wt="44357" Region 1..344 /region_name="COG5273" /note="Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]" /db_xref="CDD:227598" CDS 1..378 /gene="PFA4" /locus_tag="YOL003C" /coded_by="NM_001183257.1:1..1137" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:16647879]" /experiment="EXISTENCE:mutant phenotype:GO:0016409 palmitoyltransferase activity [PMID:16818716|PMID:26224664]" /experiment="EXISTENCE:mutant phenotype:GO:0018345 protein palmitoylation [PMID:16818716|PMID:16751107]" /note="Palmitoyltransferase with autoacylation activity; required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases" /db_xref="GeneID:854159" /db_xref="SGD:S000005363" ORIGIN 1 mpvklrwpwl giaiptflis figygahyfi lsnflsvpkq itfefclsmi wlsyylaict 61 npgrplpnyk pppdiwrnfc kkcqsykper shhcktcnqc vlmmdhhcpw tmncvgfany 121 phflrflfwi ivttsvlfci qakriyfiwq qrhlpgyffk kselifltis splnsfvllt 181 itilflrclf nqilngrsqi eswdmdrles lfnsgrltqk lidntwriyp esrsfqnkkd 241 aeehltkkrp rfdelvnfpy dfdlytnall ylgpihlwlw pygvptgdgn nfpkngisky 301 eanssledhi lslpwppdgg ktntvfnhgs stiemrnesg eqlirtrlpq ngrhasrekw 361 yndwgesldd fgvdvdme // LOCUS NP_014641 317 aa linear PLN 30-JUN-2025 DEFINITION PAQR-type receptor [Saccharomyces cerevisiae S288C]. ACCESSION NP_014641 VERSION NP_014641.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183256.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10781. On Jan 21, 2003 this sequence version replaced NP_014641.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..317 /product="PAQR-type receptor" /calculated_mol_wt="36148" Region 74..297 /region_name="HlyIII" /note="Haemolysin-III related; pfam03006" /db_xref="CDD:427098" CDS 1..317 /gene="IZH2" /locus_tag="YOL002C" /gene_synonym="PHO36" /coded_by="NM_001183256.1:1..954" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:18625204]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15664187]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:15060275]" /experiment="EXISTENCE:mutant phenotype:GO:0009636 response to toxic substance [PMID:15664187]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15664187]" /note="Plasma membrane receptor for plant antifungal osmotin; involved in zinc ion homeostasis, apoptosis; negatively regulates ZRT1 and other functionally divergent genes through CCCTC promoter motif (IzRE); modulates FET3 activity in iron-independent manner; affects gene expression by influencing balance of competition between Msn2p/Msn4p and Nrg1p/Nrg2p for binding to IzRE; transcription regulated by Zap1p, zinc, fatty acid levels; homolog of mammalian adiponectin receptor" /db_xref="GeneID:854160" /db_xref="SGD:S000005362" ORIGIN 1 mstllertks vqelkkraag ktsanpaeva kakkvlrrly swdeipewqr dndfilhgyv 61 ketssfietf kslfylhnes vniyshlipa lgfftvllld kstikvfatt twldhmvidl 121 fysgafacli lsssfhclks hslriatlgn kldylgicil ivtsmvsily ygyfekfslf 181 clfalitvsf giacsivslk dkfrkrewrp yraglfvcfg lssiipifsg lycysfseiw 241 tqiqlfwvll ggvlyiigav lygmrfpeki cpgkfdiwgh shqlfhflvv iaalchlrgl 301 lnsyelvhik mengivs // LOCUS NP_014642 293 aa linear PLN 30-JUN-2025 DEFINITION Pho80p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014642 VERSION NP_014642.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183255.1 REFERENCE 1 (residues 1 to 293) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 293) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 293) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 293) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10782. Method: conceptual translation. FEATURES Location/Qualifiers source 1..293 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..293 /product="Pho80p" /calculated_mol_wt="33096" Region 33..170 /region_name="Cyclin" /note="pfam08613" /db_xref="CDD:400780" Site order(91,93,132..138,140..142,156,159..160,163..164, 167..170) /site_type="other" /note="CDK interface [polypeptide binding]" /db_xref="CDD:410261" CDS 1..293 /gene="PHO80" /locus_tag="YOL001W" /gene_synonym="AGS3; TUP7; VAC5" /coded_by="NM_001183255.1:1..882" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9853758]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:8108735]" /experiment="EXISTENCE:direct assay:GO:1990860 Pho85-Pho80 CDK-cyclin complex [PMID:8108735]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:3915785]" /experiment="EXISTENCE:genetic interaction:GO:0045936 negative regulation of phosphate metabolic process [PMID:3915785]" /experiment="EXISTENCE:genetic interaction:GO:0050849 negative regulation of calcium-mediated signaling [PMID:16455487]" /experiment="EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:20417603]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:20429018]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:16455487]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:27252384]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:8108735]" /note="Cyclin; interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling" /db_xref="GeneID:854161" /db_xref="SGD:S000005361" ORIGIN 1 mestsgerse nihedqgipk vilpadfnkc srtdlvvlis rmlvsliain ensatkksdd 61 qitltryhsk ippnisifny firltkfssl ehcvlmtsly yidllqtvyp dftlnsltah 121 rflltattva tkglcdsfst nahyakvggv rchelnilen dflkrvnyri iprdhnitlc 181 sieqkqkkfv idknalgsld ldsysyvnrp ksgynvldky yrrivqlvgs fnaspdksrk 241 vdyvlppnid ivsesgsqtt qlkgssspns hssqkrysea kdahiynkrs kpd // LOCUS NP_014643 733 aa linear PLN 30-JUN-2025 DEFINITION exosome nuclease subunit RRP6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014643 VERSION NP_014643.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183420.1 REFERENCE 1 (residues 1 to 733) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 733) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 733) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 733) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 733) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10783. Method: conceptual translation. FEATURES Location/Qualifiers source 1..733 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..733 /product="exosome nuclease subunit RRP6" /calculated_mol_wt="83908" Region 14..100 /region_name="PMC2NT" /note="PMC2NT (NUC016) domain; pfam08066" /db_xref="CDD:462352" Region 209..399 /region_name="Rrp6p_like_exo" /note="DEDDy 3'-5' exonuclease domain of yeast Rrp6p, human polymyositis/scleroderma autoantigen 100kDa, and similar proteins; cd06147" /db_xref="CDD:99850" Site order(238..241,291..292,294..296,327..328,361,365) /site_type="active" /note="putative active site [active]" /db_xref="CDD:99850" Site order(238,240,296,361,365) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:99850" Site order(239..241,291..292,294..295,327..328,361,365) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:99850" Region 435..515 /region_name="HRDC" /note="Helicase and RNase D C-terminal; smart00341" /db_xref="CDD:128635" CDS 1..733 /gene="RRP6" /locus_tag="YOR001W" /coded_by="NM_001183420.1:1..2202" /experiment="EXISTENCE:direct assay:GO:0000175 3'-5'-RNA exonuclease activity [PMID:10611239]" /experiment="EXISTENCE:direct assay:GO:0000176 nuclear exosome (RNase complex) [PMID:19046973|PMID:10465791]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10611239|PMID:23580640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16541108|PMID:31662437]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:31662437]" /experiment="EXISTENCE:direct assay:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:15828860]" /experiment="EXISTENCE:genetic interaction:GO:0034473 U1 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:genetic interaction:GO:0034475 U4 snRNA 3'-end processing [PMID:10716935|PMID:10508172]" /experiment="EXISTENCE:genetic interaction:GO:0034476 U5 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:11586364|PMID:12417728|PMID:17410208]" /experiment="EXISTENCE:genetic interaction:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16541108]" /experiment="EXISTENCE:genetic interaction:GO:0071038 TRAMP-dependent tRNA surveillance pathway [PMID:18456844]" /experiment="EXISTENCE:genetic interaction:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:15935759]" /experiment="EXISTENCE:mutant phenotype:GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:18940861|PMID:10508172|PMID:9582370|PMID:10465791]" /experiment="EXISTENCE:mutant phenotype:GO:0000973 post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:18614049]" /experiment="EXISTENCE:mutant phenotype:GO:0032204 regulation of telomere maintenance [PMID:28160602]" /experiment="EXISTENCE:mutant phenotype:GO:0034473 U1 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0034475 U4 snRNA 3'-end processing [PMID:16373491|PMID:10508172|PMID:10611222]" /experiment="EXISTENCE:mutant phenotype:GO:0034476 U5 snRNA 3'-end processing [PMID:10508172]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:27124216]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:18007593|PMID:15173578|PMID:16431988|PMID:10465791|P MID:18940861|PMID:15572680]" /experiment="EXISTENCE:mutant phenotype:GO:0071036 nuclear polyadenylation-dependent snoRNA catabolic process [PMID:16373491]" /experiment="EXISTENCE:mutant phenotype:GO:0071037 nuclear polyadenylation-dependent snRNA catabolic process [PMID:16431988]" /experiment="EXISTENCE:mutant phenotype:GO:0071039 nuclear polyadenylation-dependent CUT catabolic process [PMID:15935759|PMID:18007593|PMID:16973436]" /experiment="EXISTENCE:mutant phenotype:GO:0071040 nuclear polyadenylation-dependent antisense transcript catabolic process [PMID:18022365]" /experiment="EXISTENCE:mutant phenotype:GO:0071042 nuclear polyadenylation-dependent mRNA catabolic process [PMID:19369424|PMID:16373491]" /experiment="EXISTENCE:mutant phenotype:GO:0071044 histone mRNA catabolic process [PMID:17179095]" /experiment="EXISTENCE:mutant phenotype:GO:0071051 poly(A)-dependent snoRNA 3'-end processing [PMID:10611222|PMID:18951092|PMID:16373491]" /note="Nuclear exosome exonuclease component; has 3'-5' exonuclease activity that is regulated by Lrp1p; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based" /db_xref="GeneID:854162" /db_xref="SGD:S000005527" ORIGIN 1 mtsenpdvll srvinvvraa sslasqdvdf yknldrgfsk dlkskadkla dmaneiilsi 61 dehhesfelk eedisdlwnn fgnimdnlle msdhsldkln cainsksrgs dlqylgefsg 121 knfsptkrve kpqlkfkspi dnseshpfip llkekpnalk plseslrlvd ddennpshyp 181 hpyeyeidhq eyspeilqir eeipskswdd svpiwvdtst elesmledlk ntkeiavdle 241 hhdyrsyygi vclmqistre rdylvdtlkl renlhilnev ftnpsivkvf hgafmdiiwl 301 qrdlglyvvg lfdtyhaska iglprhslay llenfanfkt skkyqladwr irplskpmta 361 yaradthfll niydqlrnkl iesnklagvl yesrnvakrr feyskyrplt pssevyspie 421 kespwkilmy qynipperev lvrelyqwrd liarrddesp rfvmpnqlla alvaytptdv 481 igvvsltngv tehvrqnakl lanlirdalr nikntneeat pipssetkad gilletisvp 541 qirdvmerfs vlcnsnisks rakpvtnssi llgkilpree hdiayskdgl pnkvktedir 601 iraqnfksal anlediifei ekplvvpvkl eeiktvdpas apnhspeidn lddlvvlkkk 661 niqkkqpake kgvtekdavd yskipnilsn kpgqnnrqqk krrfdpsssd sngpraakkr 721 rpaakgknls fkr // LOCUS NP_014644 544 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014644 VERSION NP_014644.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183421.1 REFERENCE 1 (residues 1 to 544) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 544) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 544) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 544) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10784. Method: conceptual translation. FEATURES Location/Qualifiers source 1..544 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..544 /product="dolichyl-P-Glc:Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase" /EC_number="2.4.1.267" /calculated_mol_wt="62652" Region 64..528 /region_name="Alg6_Alg8" /note="ALG6, ALG8 glycosyltransferase family; pfam03155" /db_xref="CDD:460831" CDS 1..544 /gene="ALG6" /locus_tag="YOR002W" /coded_by="NM_001183421.1:1..1635" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:8877369]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:8877369]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:10336995]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:15794922]" /experiment="EXISTENCE:mutant phenotype:GO:0016758 hexosyltransferase activity [PMID:8877369]" /experiment="EXISTENCE:mutant phenotype:GO:0042281 dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [PMID:10336995]" /note="ER-luminal alpha 1,3 glucosyltransferase; involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; C998T transition in human ortholog ALG6 causes carbohydrate-deficient glycoprotein syndrome type-Ic; wild-type human ortholog ALG6 can partially complement yeast alg6 mutant" /db_xref="GeneID:854163" /db_xref="SGD:S000005528" ORIGIN 1 maigkrllvn kpaeesfyas pmydflypfr pvgnqwlpey iifvcavilr ctiglgpysg 61 kgspplygdf eaqrhwmeit qhlplskwyw ydlqywgldy ppltafhsyl lgligsffnp 121 swfaleksrg fespdnglkt ymrstviisd ilfyfpaviy ftkwlgryrn qspigqsiaa 181 sailfqpslm lidhghfqyn svmlgltaya innlldeyya maavcfvlsi cfkqmalyya 241 piffayllsr sllfpkfnia rltviafatl atfaiifapl yflggglkni hqcihrifpf 301 argifedkva nfwcvtnvfv kykerftiqq lqlysliatv igflpamimt llhpkkhllp 361 yvliacsmsf flfsfqvhek tilipllpit llysstdwnv lslvswinnv alftlwpllk 421 kdglhlqyav sfllsnwlig nfsfitprfl pksltpgpsi ssinsdyrrr sllpynvvwk 481 sfiigtyiam gfyhfldqfv appskypdlw vllncavgfi cfsifwlwsy ykiftsgsks 541 mkdl // LOCUS NP_014645 478 aa linear PLN 30-JUN-2025 DEFINITION putative subtilisin-like protease YSP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014645 VERSION NP_014645.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183422.1 REFERENCE 1 (residues 1 to 478) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 478) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 478) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10785. Method: conceptual translation. FEATURES Location/Qualifiers source 1..478 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..478 /product="putative subtilisin-like protease YSP3" /calculated_mol_wt="51958" Region 70..167 /region_name="Inhibitor_I9" /note="Peptidase inhibitor I9; pfam05922" /db_xref="CDD:428674" Region 178..451 /region_name="Peptidases_S8_PCSK9_ProteinaseK_like" /note="Peptidase S8 family domain in ProteinaseK-like proteins; cd04077" /db_xref="CDD:173790" Site order(181,184..185) /site_type="other" /note="calcium binding site 2 [ion binding]" /db_xref="CDD:173790" Site order(213,245,314..315,342,404,407) /site_type="active" /db_xref="CDD:173790" Site order(213,245,407) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:173790" Site order(356,358,381) /site_type="other" /note="calcium binding site 1 [ion binding]" /db_xref="CDD:173790" CDS 1..478 /gene="YSP3" /locus_tag="YOR003W" /coded_by="NM_001183422.1:1..1437" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:17651441]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="Putative precursor of the subtilisin-like protease III; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; YSP3 has a paralog, PRB1, that arose from the whole genome duplication" /db_xref="GeneID:854164" /db_xref="SGD:S000005529" ORIGIN 1 mkfstilpil wancclcmii pdfdgivrfi enidgtrsvr ageglgqhdp gnfhtehqhv 61 ahkteflpyr yvivfnedis lqqiqshmqv vqkdhstsvg kltendafwr visssvssks 121 qfggidnffd inglfrgytg yftdeiikii sqdpiikfve qettvkisns slqeeapwgl 181 hrvshrekpk ygqdleylye daagkgvtsy vldtgidteh edfegraewg avipandeas 241 dlnghgthca giigskhfgv akntkivavk vlrsngegtv sdvikgieyv tkehiesskk 301 knkefkgsta nlslgssksl amemavnaav dsgvhfaiaa gnededacls spagaeksit 361 vgastfsddr affsnwgtcv dvfapginim styigsrnat lslsgtsmas phvagilsyf 421 lslqpapdse ffndapspqe lkekvlkfst qgvlgdigdd tpnkliyngg gkkldgfw // LOCUS NP_014646 254 aa linear PLN 30-JUN-2025 DEFINITION rRNA-binding ribosome biosynthesis protein UTP23 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014646 VERSION NP_014646.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183423.1 REFERENCE 1 (residues 1 to 254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 254) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10786. Method: conceptual translation. FEATURES Location/Qualifiers source 1..254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..254 /product="rRNA-binding ribosome biosynthesis protein UTP23" /calculated_mol_wt="28670" Region 3..150 /region_name="PIN_ScUtp23p-like" /note="VapC-like PIN domain of rRNA-processing protein, Utp23 (YOR004W), and other fungal homologs; cd09865" /db_xref="CDD:350213" Site order(9,12,15..16,19..20,42..43,45,48..49,52..53,127,135, 138..141,144..150) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:350213" Site order(64,89,91,102) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:350213" CDS 1..254 /gene="UTP23" /locus_tag="YOR004W" /coded_by="NM_001183423.1:1..765" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:16769905|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:16769905]" /experiment="EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:24152547]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16769905]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16769905]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16769905]" /experiment="EXISTENCE:mutant phenotype:GO:0070181 small ribosomal subunit rRNA binding [PMID:24152547]" /experiment="EXISTENCE:physical interaction:GO:0032040 small-subunit processome [PMID:16769905]" /note="Component of the small subunit processome; involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein" /db_xref="GeneID:854165" /db_xref="SGD:S000005530" ORIGIN 1 mrqkraksyr kqllvyshtf kfrepyqvlv dnqlvlecnn snfnlpsglk rtlqadvkvm 61 itqcciqaly etrndgainl akqferrrcn hsfkdpkspa eciesvvnis gankhryvva 121 sqdidlrrkl rtvpgvplih ltrsvmvmep lstasakask iteeqklykg lndpnieklq 181 esgdgsgkes itkkrklgpk apnplsvkkk kkvnspsdev kdkedtskek kkrrrrkhks 241 ntnvpvsngt taaq // LOCUS NP_014647 944 aa linear PLN 30-JUN-2025 DEFINITION DNA ligase (ATP) DNL4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014647 VERSION NP_014647.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183424.1 REFERENCE 1 (residues 1 to 944) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 944) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 944) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 944) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 944) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10787. Method: conceptual translation. FEATURES Location/Qualifiers source 1..944 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..944 /product="DNA ligase (ATP) DNL4" /EC_number="6.5.1.1" /calculated_mol_wt="108384" Region 84..717 /region_name="dnl1" /note="DNA ligase I, ATP-dependent (dnl1); TIGR00574" /db_xref="CDD:273147" Region 690..782 /region_name="BRCT_DNA_ligase_IV_rpt1" /note="first BRCT domain of DNA ligase 4 (LIG4) and similar proteins; cd17722" /db_xref="CDD:349354" Region 837..934 /region_name="BRCT_MDC1_rpt1" /note="first BRCT domain of mediator of DNA damage checkpoint protein 1 (MDC1) and similar proteins; cd17744" /db_xref="CDD:349375" Site order(842..843,903..905,907) /site_type="other" /note="histone H2AX interaction site [polypeptide binding]" /db_xref="CDD:349375" CDS 1..944 /gene="DNL4" /locus_tag="YOR005C" /gene_synonym="LIG4" /coded_by="NM_001183424.1:1..2835" /experiment="EXISTENCE:direct assay:GO:0003910 DNA ligase (ATP) activity [PMID:9242411|PMID:9271115]" /experiment="EXISTENCE:direct assay:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:15342630]" /experiment="EXISTENCE:mutant phenotype:GO:0003910 DNA ligase (ATP) activity [PMID:9271115]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:9242411]" /experiment="EXISTENCE:mutant phenotype:GO:0043007 maintenance of rDNA [PMID:20541983]" /experiment="EXISTENCE:physical interaction:GO:0032807 DNA ligase IV complex [PMID:17567543]" /note="DNA ligase required for nonhomologous end-joining (NHEJ); forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth; mutations in human ortholog lead to ligase IV syndrome and Dubowitz syndrome" /db_xref="GeneID:854166" /db_xref="SGD:S000005531" ORIGIN 1 misaldsipe pqnfapspdf kwlceelfvk ihevqingta gtgksrsfky yeiisnfvem 61 wrktvgnniy palvlalpyr drriynikdy vlirticsyl klpknsateq rlkdwkqrvg 121 kggnlssllv eeiakrraep sskaitidnv nhyldslsgd rfasgrgfks lvkskpflhc 181 venmsfvelk yffdivlknr viggqehkll ncwhpdaqdy lsvisdlkvv tsklydpkvr 241 lkdddlsikv gfafapqlak kvnlsyekic rtlhddflve ekmdgeriqv hymnygesik 301 ffsrrgidyt ylygaslssg tisqhlrftd svkecvldge mvtfdakrrv ilpfglvkgs 361 akealsfnsi nnvdfhplym vfdllylngt sltplplhqr kqylnsilsp lkniveivrs 421 srcygvesik kslevaislg segvvlkyyn ssynvasrnn nwikvkpeyl eefgenldli 481 vigrdsgkkd sfmlgllvld eeeykkhqgd sseivdhssq ekhiqnsrrr vkkilsfcsi 541 angisqeefk eidrktrghw krtsevappa silefgskip aewidpsesi vleiksrsld 601 ntetnmqkya tnctlyggyc krirydkewt dcytlndlye srtvksnpsy qaersqlgli 661 rkkrkrvlis dsfhqnrkql pisnifagll fyvlsdyvte dtgiritrae lektivehgg 721 kliynvilkr hsigdvrlis ckttteckal idrgydilhp nwvldciayk rliliepnyc 781 fnvsqkmrav aekrvdclgd sfendisetk lsslyksqls lppmgeleid sevrrfplfl 841 fsnriayvpr rkisteddii emkiklfggk itdqqslcnl iiipytdpil rkdcmnevhe 901 kikeqikasd tipkiarvva pewvdhsine ncqvpeedfp vvny // LOCUS NP_014648 313 aa linear PLN 30-JUN-2025 DEFINITION ribosome biogenesis protein TSR3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014648 VERSION NP_014648.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183425.1 REFERENCE 1 (residues 1 to 313) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 313) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 313) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 313) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10788. Method: conceptual translation. FEATURES Location/Qualifiers source 1..313 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..313 /product="ribosome biogenesis protein TSR3" /EC_number="2.5.1.157" /calculated_mol_wt="35555" Region 46..80 /region_name="RLI" /note="Possible Fer4-like domain in RNase L inhibitor, RLI; pfam04068" /db_xref="CDD:427689" Region 84..210 /region_name="Ribo_biogen_C" /note="Ribosome biogenesis protein, C-terminal; pfam04034" /db_xref="CDD:461139" CDS 1..313 /gene="TSR3" /locus_tag="YOR006C" /coded_by="NM_001183425.1:1..942" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:27084949|PMID:22842922|PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:19806183]" /experiment="EXISTENCE:mutant phenotype:GO:0106388 rRNA small subunit aminocarboxypropyltransferase activity [PMID:27084949]" /note="Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress; also detected in peroxisomes" /db_xref="GeneID:854167" /db_xref="SGD:S000005532" ORIGIN 1 mgkgknkmhe pkngrpqrga nghssrqnhr rmemkydnse kmkfpvklam wdfdhcdpkr 61 csgkklerlg likslrvgqk fqgivvspng kgvvcpddle iveqhgasvv ecswarleev 121 pfnkiggkhe rllpylvaan qvnygrpwrl ncvealaacf aivgrmdwas ellshfswgm 181 gflelnkell eiyqqctdcd svkraeeewl qkleketqer ksrakeediw mmgninrrgn 241 gsqsdtsese enseqsdleg nnqcieydsl gnairidnmk sreaqseese deesgskeng 301 eplsydplgn lir // LOCUS NP_014649 346 aa linear PLN 30-JUN-2025 DEFINITION Sgt2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014649 VERSION NP_014649.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183426.1 REFERENCE 1 (residues 1 to 346) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 346) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 346) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 346) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10789. Method: conceptual translation. FEATURES Location/Qualifiers source 1..346 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..346 /product="Sgt2p" /calculated_mol_wt="37087" Region 7..71 /region_name="SGTA_dimer" /note="Homodimerization domain of SGTA; pfam16546" /db_xref="CDD:465168" Region 41..221 /region_name="NlpI" /note="Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis]; COG4785" /db_xref="CDD:443815" Region 102..130 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(103,106..107,110..111,113,137,140..141,144..145, 147..148,171,174..175,178..179,182) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 135..165 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 170..198 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 264..298 /region_name="STI1" /note="Heat shock chaperonin-binding motif; smart00727" /db_xref="CDD:128966" CDS 1..346 /gene="SGT2" /locus_tag="YOR007C" /coded_by="NM_001183426.1:1..1041" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:20850366]" /experiment="EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:12482202]" /experiment="EXISTENCE:mutant phenotype:GO:0060090 molecular adaptor activity [PMID:20850366]" /note="Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:854168" /db_xref="SGD:S000005533" ORIGIN 1 msaskeeiaa livnyfssiv ekkeisedga dslnvamdci seafgferea vsgilgksef 61 kgqhladiln sasrvpesnk kddaenvein ipeddaetka kaedlkmqgn kamankdyel 121 ainkyteaik vlptnaiyya nraaahsslk eydqavkdae saisidpsyf rgysrlgfak 181 yaqgkpeeal eaykkvldie gdnateamkr dyesakkkve qslnlektvp eqsrdadvda 241 sqgasagglp dlgsllgggl gglmnnpqlm qaaqkmmsnp gamqniqkmm qdpsirqmae 301 gfasgggtpn lsdlmnnpal rnmagnlfgg agaqstdetp dnenkq // LOCUS NP_014650 378 aa linear PLN 30-JUN-2025 DEFINITION Slg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014650 VERSION NP_014650.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183427.1 REFERENCE 1 (residues 1 to 378) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 378) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 378) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 378) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 378) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10790. Method: conceptual translation. FEATURES Location/Qualifiers source 1..378 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..378 /product="Slg1p" /calculated_mol_wt="39139" Region 22..110 /region_name="WSC" /note="present in yeast cell wall integrity and stress response component proteins; smart00321" /db_xref="CDD:214616" CDS 1..378 /gene="SLG1" /locus_tag="YOR008C" /gene_synonym="HCS77; WSC1" /coded_by="NM_001183427.1:1..1137" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:20652590|PMID:9391108]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:20652590]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:20652590|PMID:17761172]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0004888 transmembrane signaling receptor activity [PMID:10430578]" /experiment="EXISTENCE:genetic interaction:GO:0006970 response to osmotic stress [PMID:14871941]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20385774]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:30361468]" /experiment="EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:10348843|PMID:10508863]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10348843|PMID:10508863]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:10508863|PMID:24326069]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:10508863]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:10348843]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:24326069|PMID:14593073]" /note="Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response" /db_xref="GeneID:854170" /db_xref="SGD:S000005534" ORIGIN 1 mrpnktslll allsilsqan ayeyvncfss lpsdfskads ynwqssshcn secsakgasy 61 falynhsecy cgdtnpsgse stssscntyc fgyssemcgg edaysvyqld sdtnsnsiss 121 sdsstestsa sssttsstts sttsttsstt ssttssmass stvqnspest qaaasistsq 181 ssstvtsess ltsdtlatss tssqsqdats iiysttfhte ggstifvtnt itasaqnsgs 241 atgtagsdst sgskthkkka nvgaivggvv ggvvgavaia lcillivrhi nmkreqdrme 301 keyqeaikpv eypdklyass fssnhgpssg sfeeehtkgq tdinpfddsr risngtfing 361 gpggknnvlt vvnpdead // LOCUS NP_014651 74 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR008C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_014651 VERSION NP_014651.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184305.1 REFERENCE 1 (residues 1 to 74) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 74) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 74) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 74) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 74) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10791. Method: conceptual translation. FEATURES Location/Qualifiers source 1..74 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..74 /product="uncharacterized protein" /calculated_mol_wt="8473" CDS 1..74 /locus_tag="YOR008C-A" /coded_by="NM_001184305.1:1..225" /note="hypothetical protein; includes a potential transmembrane domain; deletion results in slightly lengthened telomeres; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /db_xref="GeneID:854171" /db_xref="SGD:S000006431" ORIGIN 1 mwrsylvflf fmtpriqtyc pvpvlrsmav lniispliif vspikkqdsl hssacyanlt 61 lveklqlwhs msnd // LOCUS NP_014652 487 aa linear PLN 30-JUN-2025 DEFINITION Tir4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014652 VERSION NP_014652.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183428.1 REFERENCE 1 (residues 1 to 487) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 487) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 487) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 487) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10792. Method: conceptual translation. FEATURES Location/Qualifiers source 1..487 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..487 /product="Tir4p" /calculated_mol_wt="47718" Region 19..113 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..487 /gene="TIR4" /locus_tag="YOR009W" /coded_by="NM_001183428.1:1..1464" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Cell wall mannoprotein; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins" /db_xref="GeneID:854173" /db_xref="SGD:S000005535" ORIGIN 1 mayskitlla alaaiayaqt qaqinelnvv lddvktniad yitlsytpns gfsldqmpag 61 imdiaaqlva npsddsyttl ysevdfsave hmltmvpwys srllpeleam daslttsssa 121 atsssevass siasstsssv apsssevvss svapsssevv sssvapssse vvsssvasss 181 sevasssvap sssevvsssv assssevass svapsssevv sssvapssse vvsssvasss 241 sevasssvap sssevvsssv asstseatss savtsssavs sstesvssss vssssavsss 301 eavssspvss vvsssagpas ssvapynsti asssstaqts istiapynst ttttpassas 361 sviistrngt tvtetdntlv tkettvcdys stsavpastt gynnstkvst aticstckeg 421 tstatdfstl kttvtvcdsa cqakksatvv svqskttgiv eqtengaaka vigmgagala 481 avaamll // LOCUS NP_014653 251 aa linear PLN 30-JUN-2025 DEFINITION putative GPI-anchored mannoprotein [Saccharomyces cerevisiae S288C]. ACCESSION NP_014653 VERSION NP_014653.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183429.1 REFERENCE 1 (residues 1 to 251) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 251) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 251) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 251) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10793. Method: conceptual translation. FEATURES Location/Qualifiers source 1..251 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..251 /product="putative GPI-anchored mannoprotein" /calculated_mol_wt="24497" Region 19..111 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" Region 207..223 /region_name="PIR" /note="Yeast PIR protein repeat; pfam00399" /db_xref="CDD:395322" CDS 1..251 /gene="TIR2" /locus_tag="YOR010C" /gene_synonym="SRP2" /coded_by="NM_001183429.1:1..756" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071497 cellular response to freezing [PMID:7746155]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Putative cell wall mannoprotein; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis; TIR2 has a paralog, TIR3, that arose from the whole genome duplication" /db_xref="GeneID:854174" /db_xref="SGD:S000005536" ORIGIN 1 mayikialla aiaalasaqt qeeidelnvi lndvksnlqe yislaedsss gfslsslpsg 61 vldiglalas atddsyttly sevdfaavsk mltmvpwyss rllpelesll gtsttaasst 121 eassaatssa vasssettss avassseats savassseas ssaatssava ssseatsstv 181 asstkaasst kasssavssa vasstkasai sqisdgqvqa tstvseqten gaakavigmg 241 agvmaaaaml l // LOCUS NP_014654 1394 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette sterol transporter AUS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014654 VERSION NP_014654.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183430.1 REFERENCE 1 (residues 1 to 1394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1394) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10794. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1394 /product="ATP-binding cassette sterol transporter AUS1" /calculated_mol_wt="157621" Region 56..1369 /region_name="3a01205" /note="Pleiotropic Drug Resistance (PDR) Family protein; TIGR00956" /db_xref="CDD:273362" CDS 1..1394 /gene="AUS1" /locus_tag="YOR011W" /coded_by="NM_001183430.1:1..4185" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21521689]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0035376 sterol import [PMID:12077145|PMID:21110944]" /experiment="EXISTENCE:mutant phenotype:GO:0034041 ABC-type sterol transporter activity [PMID:21521689]" /experiment="EXISTENCE:mutant phenotype:GO:0035376 sterol import [PMID:21521689|PMID:12077145]" /note="Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen; AUS1 has a paralog, PDR11, that arose from the whole genome duplication" /db_xref="GeneID:854175" /db_xref="SGD:S000005537" ORIGIN 1 msiskyftpv adgsltfnga niqfgadaqg eskksydaed smpnpanqln ditfqaeage 61 mvlvlgypts tlfktlfhgk tslsysppgs ikfknnefks fsekcphqii ynneqdvhfp 121 fltveqtidf alsckfdipk gerdqirnel lrefglshvl ktivgndffr gvsggerkri 181 siietfiang svylwdnstk gldsataldf leilrkmaka trsvnlvris qasdkivdkf 241 dkilmlsdsy qlfygtvdec ltyfrdtlgi ekdpndciie yltsilnfqf knknlgnlsn 301 sssasvlkta tgevtkytyn sdfdlydqwk hssyyrnikq qiqgssidds ikevdpsdvs 361 pifniplkkq llfctkrafq rslgdkaymt aqfisvviqs lvigslfyei plttigsysr 421 gsltffsilf ftflsladmp iafqrqpvvk kqsqlhfytn wvetlsttvf dycfklclvi 481 vfsiilyfla hlqykaarff ifllflsfyn fcmvslfalt tlvaptisva nlfagillla 541 iamyasyviy lknmhpwfvw iaylnpamya meailsnely nlkldcseti vprgptyndv 601 pfshkacawq gatlgndyvr grdylkqgls ytyhhvwrnf giiigflvff iactlfasqy 661 ikpyfnkdei ernnsrltrw lpflnkkrgt rssarndsky vgipkshsvs ssssslsavp 721 yqispsnkem alndyneqpi tetvetqkhi iswkninytv gtkklinnas gfissgltal 781 mgesgagktt llnvlsqrve tgvvsgeili dghpltdeda fkrsigfvqq qdlhldllsv 841 kesleiscll rgdgdrayld tvsnllklps dilvadlnpt qrkllsigve lvtkpslllf 901 ldeptsglda eaaltivkfl kqlslqgqai fctihqpsks vishfdnifl lkrggecvff 961 gpmddacgyf mshdntlvyd kehdnpadfv idavgnsnss agkdtaeeal tlnkeaidws 1021 alwessvekk lvkketarle ddarasgvdy ttslwkqpsy lqqlalitrr qyictkrdmt 1081 yvmakyclng gaglfigfsf whikhniigl qdsiffcfma lcvssplinq iqdkalktke 1141 vyvarearsn tyhwtvllls qsiielplal tsstlffvca ffscgfnnag wsagvfflny 1201 mlfaayystl glwliytapn lqtaavfvaf iysftasfcg vmqpyslfpt fwkfmyrvsp 1261 ytyfvetfvs illhnweikc dmsemvpgqp ltgqscgqfm eafieeyggy lhnkntftvc 1321 ayctytvgdd flknenmsyd hvwrnfgiew afvgfnffam fagyyltyva riwpkvfkii 1381 tkviphrgkk pvqn // LOCUS NP_878167 68 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR011W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878167 VERSION NP_878167.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184576.1 REFERENCE 1 (residues 1 to 68) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 68) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 68) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 68) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10795. Method: conceptual translation. FEATURES Location/Qualifiers source 1..68 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..68 /product="uncharacterized protein" /calculated_mol_wt="8507" CDS 1..68 /locus_tag="YOR011W-A" /coded_by="NM_001184576.1:1..207" /note="hypothetical protein" /db_xref="GeneID:1466479" /db_xref="SGD:S000028581" ORIGIN 1 maksvfnffh feileylnrf vyhsqyflpy ycslevlgks rknwtfqywc lyittdkkii 61 kkkdfyhr // LOCUS NP_014655 137 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR012W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014655 VERSION NP_014655.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183431.1 REFERENCE 1 (residues 1 to 137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 137) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10796. Method: conceptual translation. FEATURES Location/Qualifiers source 1..137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..137 /product="uncharacterized protein" /calculated_mol_wt="15351" CDS 1..137 /locus_tag="YOR012W" /coded_by="NM_001183431.1:1..414" /note="hypothetical protein" /db_xref="GeneID:854177" /db_xref="SGD:S000005538" ORIGIN 1 mvassinees slavnltsdv ekasktlfka feksyandyl mkkffhipit ekvsrarina 61 mihyyttcyh dldgeiaean dfdavaiwsr pgchlpatls ddesfnkiff srldceears 121 hasgnglllp lchrkrs // LOCUS NP_014657 757 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase 2A regulatory subunit RTS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014657 VERSION NP_014657.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183433.1 REFERENCE 1 (residues 1 to 757) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 757) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 757) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 757) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 757) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 757) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 757) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 757) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 757) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10797. Method: conceptual translation. FEATURES Location/Qualifiers source 1..757 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..757 /product="protein phosphatase 2A regulatory subunit RTS1" /calculated_mol_wt="85204" Region 284..710 /region_name="B56" /note="Protein phosphatase 2A regulatory B subunit (B56 family); pfam01603" /db_xref="CDD:460264" CDS 1..757 /gene="RTS1" /locus_tag="YOR014W" /gene_synonym="SCS1" /coded_by="NM_001183433.1:1..2274" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:12636916|PMID:23785440]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:31781172]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12388751|PMID:22842922|PMID:12636916]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:12388751]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12388751|PMID:12636916]" /experiment="EXISTENCE:direct assay:GO:0019888 protein phosphatase regulator activity [PMID:9079645]" /experiment="EXISTENCE:genetic interaction:GO:0031134 sister chromatid biorientation [PMID:25236599]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:19605686]" /experiment="EXISTENCE:genetic interaction:GO:0032186 cellular bud neck septin ring organization [PMID:12636916]" /experiment="EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:27973551]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:31781172]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:19605686]" /experiment="EXISTENCE:mutant phenotype:GO:0031107 septin ring disassembly [PMID:12636916]" /experiment="EXISTENCE:mutant phenotype:GO:0032186 cellular bud neck septin ring organization [PMID:12636916]" /experiment="EXISTENCE:mutant phenotype:GO:0051754 meiotic sister chromatid cohesion, centromeric [PMID:16541024]" /experiment="EXISTENCE:mutant phenotype:GO:0070199 establishment of protein localization to chromosome [PMID:24945276]" /note="B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A" /db_xref="GeneID:854179" /db_xref="SGD:S000005540" ORIGIN 1 mmrgfkqrli kkttgsssss sskkkdkeke kekssttsst skkpasasss shgtthssas 61 stgsksttek gkqsgsvpsq gkhhssstsk tktattpsss ssssrsssvs rsgssstkkt 121 ssrkgqeqsk qsqqpsqsqk qgsssssaai mnptpvltvt kddkstsged hahptllgav 181 savpsspisn asgtavssdv engnsnnnnm nintsntqda nhassqsidi prsshsferl 241 ptptklnpdt dleliktpqr hsssrfepsr ytpltklpnf nevspeerip lfiakvdqcn 301 tmfdfndpsf diqgkeikrs tldelieflv tnrftytnem yahvvnmfki nlfrpipppv 361 npvgdiydpd edepvnelaw phmqavyeff lrfvespdfn hqiakqyidq dfilkllelf 421 dsedirerdc lkttlhriyg kflslrsfir rsmnniflqf iyetekfngv aelleilgsi 481 ingfalplke ehkvflvril iplhkvrcls lyhpqlayci vqflekdpll teevvmgllr 541 ywpkinstke imflneiedi fevieplefi kvevplfvql akcissphfq vaekvlsywn 601 neyflnlcie naevilpiif palyeltsql eldtangeds isdpymlveq ainsgswnra 661 ihamafkalk ifletnpvly encnalylss vketqqrkvq reenwsklee yvknlrinnd 721 kdqytiknpe lrnsfntase nntlneenen dcdseiq // LOCUS NP_001335814 119 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR015W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335814 VERSION NP_001335814.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348876.1 REFERENCE 1 (residues 1 to 119) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 119) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 119) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 119) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80334. Method: conceptual translation. FEATURES Location/Qualifiers source 1..119 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..119 /product="uncharacterized protein" /calculated_mol_wt="13742" CDS 1..119 /locus_tag="YOR015W" /coded_by="NM_001348876.1:1..360" /note="hypothetical protein; conserved among S. cerevisiae strains; YOR015W is not an essential gene" /db_xref="GeneID:854180" /db_xref="SGD:S000005541" ORIGIN 1 mphfkraavy eeqkrtgkwg qlveetkdri peysnktiak ishldngclw peikvsfshh 61 lsilqsmclh fiisilfsky ifvflfafll psafplfilh stlfrkpcls iigflktkv // LOCUS NP_014659 207 aa linear PLN 30-JUN-2025 DEFINITION Erp4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014659 VERSION NP_014659.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183435.1 REFERENCE 1 (residues 1 to 207) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 207) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 207) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 207) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10798. Method: conceptual translation. FEATURES Location/Qualifiers source 1..207 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..207 /product="Erp4p" /calculated_mol_wt="23384" Region 29..199 /region_name="EMP24_GP25L" /note="emp24/gp25L/p24 family/GOLD; pfam01105" /db_xref="CDD:426051" CDS 1..207 /gene="ERP4" /locus_tag="YOR016C" /coded_by="NM_001183435.1:1..624" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10359606]" /note="Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; ERP4 has a paralog, ERP2, that arose from the whole genome duplication" /db_xref="GeneID:854181" /db_xref="SGD:S000005542" ORIGIN 1 mrvftliail fsssllthaf ssnyapvgis lpaftkecly ydlssdkdvl vvsyqvltgg 61 nfeidfdita pdgsvivter qkkhsdfllk sfgigkytfc lsnnygtspk kveitlekek 121 eivssheske diiannaiee idrnlnkitk tmdylrarew rnmytvsste srltwlslli 181 mgvmvgisiv qaliiqffft srqknyv // LOCUS NP_014660 800 aa linear PLN 30-JUN-2025 DEFINITION Pet127p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014660 VERSION NP_014660.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183436.1 REFERENCE 1 (residues 1 to 800) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 800) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 800) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 800) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10799. Method: conceptual translation. FEATURES Location/Qualifiers source 1..800 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..800 /product="Pet127p" /calculated_mol_wt="93277" Region 242..540 /region_name="Pet127" /note="Mitochondrial protein Pet127; pfam08634" /db_xref="CDD:430119" CDS 1..800 /gene="PET127" /locus_tag="YOR017W" /coded_by="NM_001183436.1:1..2403" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:9111353]" /experiment="EXISTENCE:mutant phenotype:GO:0000964 mitochondrial RNA 5'-end processing [PMID:9111353|PMID:18086665]" /note="Protein with a role in 5'-end processing of mitochondrial RNAs; located in the mitochondrial membrane" /db_xref="GeneID:854182" /db_xref="SGD:S000005543" ORIGIN 1 mgfyncrfls rrlsvepcri gsaaksyqqr siyhfgaalt napsgretpd klrsdlhsal 61 emvdeiydtn stvedignke kggrqkytee mdkainllkt nikkeyrhdk ylertkvgty 121 pgrrtypgrr typarrtypa srtysdsnsy tfrinvqkir halvrynqdg vqkhnqkppr 181 ighgltrvly qplslqklrd nrsrmynfdp aveninpeyl ekksekdvnt dssgegqskp 241 ifitphkdes llkvakehrk kyisssssmt svlsqlhyll snfrrlniid ssisknfpqk 301 ncnysesayf psavilrkkr ngicsidsdr sldreivlsv lghyledflt ekslknssks 361 enyhysside fivrsqlday dpnlpgtgvf dlktravsai rydlshvesn nnqtgyeidk 421 vygefesler eyfelirsal lkyslqarig kmdgifvayh niskmfgfqy lpldeldyii 481 hssynskfds llkeknditk giygeedyil hydrddrkia clvanrefkm smnlfsnilk 541 hveqllnssn tkwekckiml kteveekrsk sgrffnepvl nivalplspe yedksllvkd 601 tsneqlteel lnlrsynenl leehlnslvg fkvnvkhfyh hhpntthlpd falkkndild 661 tesrkyisdm mkrdwykdip stqtpnffha sdvstwevns tftdindkqi lrklyfkyld 721 vklnalknqv itrqepdmsk kdeimnriks lqarndhrdn gsnkrysnfg ptrlqtklra 781 yakkgalrrk llersnkfhi // LOCUS NP_014661 837 aa linear PLN 30-JUN-2025 DEFINITION Rod1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014661 VERSION NP_014661.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183437.1 REFERENCE 1 (residues 1 to 837) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 837) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 837) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 837) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 837) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10800. Method: conceptual translation. FEATURES Location/Qualifiers source 1..837 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..837 /product="Rod1p" /calculated_mol_wt="92219" Region <157..215 /region_name="Arrestin_N" /note="Arrestin (or S-antigen), N-terminal domain; cl22903" /db_xref="CDD:451447" Region 232..395 /region_name="Arrestin_C" /note="Arrestin (or S-antigen), C-terminal domain; smart01017" /db_xref="CDD:214976" CDS 1..837 /gene="ROD1" /locus_tag="YOR018W" /gene_synonym="ART4" /coded_by="NM_001183437.1:1..2514" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8621680]" /experiment="EXISTENCE:direct assay:GO:0031625 ubiquitin protein ligase binding [PMID:24820415]" /experiment="EXISTENCE:direct assay:GO:0071333 cellular response to glucose stimulus [PMID:22249293]" /experiment="EXISTENCE:genetic interaction:GO:0002092 positive regulation of receptor internalization [PMID:24820415]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:12163175]" /experiment="EXISTENCE:mutant phenotype:GO:0031625 ubiquitin protein ligase binding [PMID:24820415]" /experiment="EXISTENCE:mutant phenotype:GO:0070086 ubiquitin-dependent endocytosis [PMID:22249293]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]" /note="Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication" /db_xref="GeneID:854183" /db_xref="SGD:S000005544" ORIGIN 1 mfssssrpsk epllfdirlr nldndvllik gppdeassvl lsgtivlsit epiqikslal 61 rlfgrlrlni ptvlqtvhgp hkryskfern iyshfwddfn iksyfqnlyd nhnngkitis 121 sksstnlaal pkrkralsta slissngqts asknyhtlvk gnyefpfsai ipgslvesve 181 glpnaavtya leatierpkq pdlickkhlr virtlaidav elsetvsvdn swpekvdyti 241 siptkaiaig sstminiliv pilkglklgp vrislvensq ycgsyggvin qermvaklkl 301 kdplkhvaqi kkkrslneaa degvdtdtge fqdkwevral lnipasltkc sqdcrilsni 361 kvrhkikfti sllnpdghis elraalpvql fispfvpvnv ktsdviertl ktfgpsyqvt 421 sqhdnsfssk nfvddseedv ifqrsasalq lssmptivsg stlninstda eatavadttm 481 vtslmvppny gnhvydrvyg evtnedetsa sasssavesq aihniqnlyi sdsnnsnnpi 541 lapnpqikie ddslnncdsr gdsvnnsnln lvnsnltise nwnnnspsan rynniinagl 601 nspsltpsfa hlsrrnsysr qtsstslknd leltdlsrvp sydkamksdm igedlppayp 661 eeelgvqenk kielerpqil hhkstssllp lpgsskssnn lkrsssrthl shsplprnns 721 gssvslqqla rnntdssfnl nlsftsakss tgsrhfpfnm ttsftsnsss knnshfdktd 781 stsdankpre eenytsathn rrsrsssvrs nnsnsplrqg tgsfanlmem ftkrdrs // LOCUS NP_014662 730 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR019W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014662 VERSION NP_014662.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183438.1 REFERENCE 1 (residues 1 to 730) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 730) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 730) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 730) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 730) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10801. Method: conceptual translation. FEATURES Location/Qualifiers source 1..730 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..730 /product="uncharacterized protein" /calculated_mol_wt="83235" Region 241..>356 /region_name="AANH_superfamily" /note="Adenine nucleotide alpha hydrolase (AANH) superfamily; cl00292" /db_xref="CDD:469708" CDS 1..730 /locus_tag="YOR019W" /coded_by="NM_001183438.1:1..2193" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; YOR019W has a paralog, JIP4, that arose from the whole genome duplication" /db_xref="GeneID:854184" /db_xref="SGD:S000005545" ORIGIN 1 misvcpqndl qkcyrsltfd vpgqqfeern eqnlkkrakk kgsfqpsvaf dtvpstagys 61 siddsregfk gvpvpnyytm eecyddetds fspnlqyylr dtfqsspfln trkenksess 121 sfpmrsskll eknsdikkyf lvskngkivr rdypstpviv netlminrfe knwiklwrqr 181 klqinerlnd kkkwftypel ifseerikpl yrgddsapct keqkrkhkil qqkvgypnnp 241 ktivchingk khtwvaldwt vykfarnldh ivvittlpkm isnrkktakd dtewapgyqk 301 evidqklndi fdyilqlvkv vkisvkitle iivgkikksl vdvinvhtpd flvlatlkhe 361 rnenlityks kkltdvfpvs ypiptfvvps krmysfelnl qrevnehyvs knhmkhehtd 421 vesmsssmfk kntisdissh isvdsyaedf krqgyikkqf ntsndsiprk ltglaqhsrr 481 kitgdieklq ddekdrectk eklllkkidi iireslkssl aietlpgknv sqsshgdqis 541 sfknaligng skntkfrksl ipyssseeqn ttttiklsss ptsqikfats vkhkdgraal 601 gkarnlpdir hsisfdkens fdpsdksssv dnsiplrkvk sagalrkvkt ndssssagsk 661 kssssfstvn tftgggvgif kvfksgsssg nksssrrnss sgdvfesddr ndkkkkkkkk 721 kkslflfgki // LOCUS NP_014663 106 aa linear PLN 30-JUN-2025 DEFINITION Hsp10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014663 VERSION NP_014663.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183439.1 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10802. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..106 /product="Hsp10p" /calculated_mol_wt="11241" Region 10..103 /region_name="cpn10" /note="Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; cd00320" /db_xref="CDD:238197" Site order(10,12,14,17,44..45,66,76,81,83,100..102) /site_type="other" /note="oligomerisation interface [polypeptide binding]" /db_xref="CDD:238197" Site 26..39 /site_type="active" /note="mobile loop [active]" /db_xref="CDD:238197" Site order(53,64) /site_type="active" /note="roof hairpin [active]" /db_xref="CDD:238197" CDS 1..106 /gene="HSP10" /locus_tag="YOR020C" /gene_synonym="CPN10" /coded_by="NM_001183439.1:1..321" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:7903252]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:7902576]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9256426]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:7902576]" /experiment="EXISTENCE:mutant phenotype:GO:0042026 protein refolding [PMID:9256426]" /experiment="EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:7913473]" /experiment="EXISTENCE:mutant phenotype:GO:0051131 chaperone-mediated protein complex assembly [PMID:7913473]" /experiment="EXISTENCE:physical interaction:GO:0051087 protein-folding chaperone binding [PMID:9256426]" /note="Mitochondrial matrix co-chaperonin; inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES" /db_xref="GeneID:854185" /db_xref="SGD:S000005546" ORIGIN 1 mstllksaks ivplmdrvlv qrikaqakta sglylpeknv eklnqaevva vgpgftdang 61 nkvvpqvkvg dqvlipqfgg stiklgndde vilfrdaeil akiakd // LOCUS NP_878168 90 aa linear PLN 30-JUN-2025 DEFINITION Mco10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878168 VERSION NP_878168.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184536.1 REFERENCE 1 (residues 1 to 90) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 90) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 90) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 90) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 90) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10803. Method: conceptual translation. FEATURES Location/Qualifiers source 1..90 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..90 /product="Mco10p" /calculated_mol_wt="9487" Region 4..82 /region_name="ATP19" /note="ATP synthase subunit K; pfam11022" /db_xref="CDD:431614" CDS 1..90 /gene="MCO10" /locus_tag="YOR020W-A" /coded_by="NM_001184536.1:1..273" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0045259 proton-transporting ATP synthase complex [PMID:36882574]" /experiment="EXISTENCE:genetic interaction:GO:0055074 calcium ion homeostasis [PMID:36882574]" /experiment="EXISTENCE:mutant phenotype:GO:0055074 calcium ion homeostasis [PMID:36882574]" /note="Subunit l of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; more abundant in the ATP synthase monomer; involved in the calcium-induced permeability transition and calcium homeostasis; does not impact ATP synthase activity and stability; N-terminal region has sequence similarity to Atp19p; conserved in A. gossypii; detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:1466480" /db_xref="SGD:S000028526" ORIGIN 1 mgaaykvfgk tvqphvlais tfiataavas yfttkpktkn egknssalsq qksgessnsd 61 amgkdddvvk siegflndle kdtrqdtkan // LOCUS NP_014664 213 aa linear PLN 30-JUN-2025 DEFINITION protein-arginine N-methyltransferase SFM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014664 VERSION NP_014664.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183440.1 REFERENCE 1 (residues 1 to 213) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 213) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 213) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 213) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10804. Method: conceptual translation. FEATURES Location/Qualifiers source 1..213 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..213 /product="protein-arginine N-methyltransferase SFM1" /calculated_mol_wt="24612" Region 2..206 /region_name="RNA_Me_trans" /note="Predicted SAM-dependent RNA methyltransferase; pfam04252" /db_xref="CDD:427819" CDS 1..213 /gene="SFM1" /locus_tag="YOR021C" /coded_by="NM_001183440.1:1..642" /experiment="EXISTENCE:direct assay:GO:0035241 protein-arginine omega-N monomethyltransferase activity [PMID:22650761]" /experiment="EXISTENCE:mutant phenotype:GO:0018216 peptidyl-arginine methylation [PMID:22650761]" /note="SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism" /db_xref="GeneID:854186" /db_xref="SGD:S000005547" ORIGIN 1 mkyiiehmee gfsewviley sqilrevgae nlilsslpes ttekdipqrl lklglrwttk 61 dlkginedfk dlellkdgrv clldpratid lqpedatkfd yfvfggilgd hpprdrtkel 121 ktaypnllis rrlgdkqmtt dtairttqli ikdriafedi kfidypefrf nkneatempf 181 ryvldkegkp ilpegmldli kkdsaqsldd llm // LOCUS NP_014665 715 aa linear PLN 30-JUN-2025 DEFINITION putative carboxylic ester hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014665 VERSION NP_014665.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183441.1 REFERENCE 1 (residues 1 to 715) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 715) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 715) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 715) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10805. Method: conceptual translation. FEATURES Location/Qualifiers source 1..715 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..715 /product="putative carboxylic ester hydrolase" /calculated_mol_wt="81638" Region 519..699 /region_name="DDHD" /note="DDHD domain; pfam02862" /db_xref="CDD:460725" CDS 1..715 /gene="DDL1" /locus_tag="YOR022C" /coded_by="NM_001183441.1:1..2148" /experiment="EXISTENCE:direct assay:GO:0004620 phospholipase activity [PMID:27746179|PMID:27402848]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:27746179]" /experiment="EXISTENCE:mutant phenotype:GO:0004620 phospholipase activity [PMID:27402848]" /experiment="EXISTENCE:mutant phenotype:GO:0006644 phospholipid metabolic process [PMID:27402848]" /experiment="EXISTENCE:mutant phenotype:GO:0032048 cardiolipin metabolic process [PMID:27402848]" /experiment="EXISTENCE:mutant phenotype:GO:0046337 phosphatidylethanolamine metabolic process [PMID:27402848]" /note="DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism" /db_xref="GeneID:854187" /db_xref="SGD:S000005548" ORIGIN 1 mlrfthrglp sstrfrnifv rlnhiyvpwf yaidvpnskp ylptyqtlhs pkkfkpfsvd 61 dsnrlekask rqerrpvlvn edylfkvdls hmelsptywe gptyqvrrgv wfdssnqpls 121 sdltseiegl ykqlkfddsn ddptttppae sqdifrlkgk ypvdkenege qkngssnkde 181 nestfkfilf ankqtaflls dldggklqla flrsnlaqsl pinatmitrs ykysssattk 241 qtstsfkaak tpqtevadgs nssksrsiet klekkvsnlf nlsdflqlfn gnaskdqdda 301 qslekqmetd ynnadnsqga nasskiedgk nsgasdrqir snrrdvdnli lcvhgigqtl 361 gkkyeyvnfa htvnllrsnm kkiynnsekl qslntapdyk sncnvqvlpi twrhsisfqt 421 dakeenienp dlptlsqvtv ngvlplrkll adglldilly vepyyqdmil qqvtsqlnkt 481 yrifkefnpe fdgkvhlvgh slgsmilfdi lskqkkyele fqvdnlffig spigllkliq 541 rtkigdrpef pndlerkltv qrpqckdiyn vyhvcdpisy rmeplvskem ahyeqtylph 601 cseaygltsk vlefgeniwk dlpgtdennl qskktspekk evklsenltr mltglnytgr 661 ldyamspsll evdfisaiks hvsyfeepdi aafilkeils khenaseiyv krktg // LOCUS NP_014666 566 aa linear PLN 30-JUN-2025 DEFINITION Ahc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014666 VERSION NP_014666.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183442.1 REFERENCE 1 (residues 1 to 566) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 566) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 566) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 566) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10806. Method: conceptual translation. FEATURES Location/Qualifiers source 1..566 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..566 /product="Ahc1p" /calculated_mol_wt="63738" CDS 1..566 /gene="AHC1" /locus_tag="YOR023C" /coded_by="NM_001183442.1:1..1701" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:10490601]" /experiment="EXISTENCE:direct assay:GO:0140671 ADA complex [PMID:10490601]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="Subunit of the Ada histone acetyltransferase complex; required for structural integrity of the complex; Ahc2p and Ahc1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; Ahc2p may tether Ahc1p to the complex" /db_xref="GeneID:854188" /db_xref="SGD:S000005549" ORIGIN 1 mmspaqdklq hqhhnpnsss sssskmtnvy qvttpkspqd lennmdepfk mdtatsnpdk 61 dsentqrlky ecakgeiqnv lnlhimlnhk hvrhlrrnvq kvnaklalle tlhkdtglln 121 kiertyqlki kqhqqhsvlg ghfhdstate ntnasnynls ypvlsdynin cqplssssnr 181 nlsttriphh hyhtrsksng lllepsalrp ansniidyrl tgskslseai tkptpvslph 241 snsdgisspr sssispldeq pgfqilpfkp sqmhlnhrrn ysstcltsns giigktenne 301 pifrrydgil viitcskcdr sgftsaqgiv nhtrlkhskl yssqplavln nqkllpndkq 361 dpeilskfkk lnldpnkdyl psdiaipkpq spinhsenht rapktvkntp hleklyqnke 421 dfkklidmvn etpddlneyl kqreiqlryq keqeeessks ddeasyvpsp slsatatttt 481 ttdppsppvl ssslqrkllr krklslnsst pmedlplrer lranptdkkp rkaalltnel 541 egpdpaakss syynlrsksr lrgsht // LOCUS NP_014668 447 aa linear PLN 30-JUN-2025 DEFINITION NAD-dependent histone deacetylase HST3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014668 VERSION NP_014668.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183444.1 REFERENCE 1 (residues 1 to 447) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 447) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 447) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 447) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 447) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10807. Method: conceptual translation. FEATURES Location/Qualifiers source 1..447 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..447 /product="NAD-dependent histone deacetylase HST3" /EC_number="2.3.1.286" /calculated_mol_wt="50393" Region 53..332 /region_name="SIR2-fam" /note="SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; cd01407" /db_xref="CDD:238698" Site order(62,64..65,72..73,133,151..152,154,187,282,287, 313..314,332) /site_type="other" /note="NAD+ binding site [chemical binding]" /db_xref="CDD:238698" Site order(153,187,250,252..256,286..288) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238698" Site order(195,198,220,223) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:238698" CDS 1..447 /gene="HST3" /locus_tag="YOR025W" /coded_by="NM_001183444.1:1..1344" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:12242223]" /experiment="EXISTENCE:direct assay:GO:0006351 DNA-templated transcription [PMID:31167142]" /experiment="EXISTENCE:direct assay:GO:0009299 mRNA transcription [PMID:31167142]" /experiment="EXISTENCE:direct assay:GO:0017136 histone deacetylase activity, NAD-dependent [PMID:17977840]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:7498786]" /experiment="EXISTENCE:mutant phenotype:GO:0017136 histone deacetylase activity, NAD-dependent [PMID:17977840]" /experiment="EXISTENCE:mutant phenotype:GO:0046459 short-chain fatty acid metabolic process [PMID:12618394]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="Sirtuin, histone H3 deacetylase; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; member of the Sir2 family of NAD(+)-dependent protein deacetylases" /db_xref="GeneID:854190" /db_xref="SGD:S000005551" ORIGIN 1 mtsvspsppa srsgsmcsdl psslqtekla hiigldadde vlrrvtkqls rsrriacltg 61 agiscnagip dfrssdglyd lvkkdcsqyw siksgremfd islfrddfki sifakfmerl 121 ysnvqlakpt kthkfiahlk drnkllrcyt qnidgleesi gltlsnrklp ltsfsshwkn 181 ldvvqlhgdl ktlsctkcfq tfpwsrywsr clrrgelplc pdcealinkr lnegkrtlgs 241 nvgilrpniv lygenhpsce iitqglnldi ikgnpdflii mgtslkvdgv kqlvkklskk 301 ihdrggliil vnktpigess whgiidyqih sdcdnwvtfl esqipdffkt qdqikklrql 361 kreasdlrkq mkaqkdsigt ppttplrtaq gidiqgnnel ntkikslntv krkilspens 421 seedeeenld trkrakirpt fgdnqas // LOCUS NP_014669 341 aa linear PLN 30-JUN-2025 DEFINITION Bub3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014669 VERSION NP_014669.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183445.1 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10808. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..341 /product="Bub3p" /calculated_mol_wt="38314" Region 14..55 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 60..97 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 104..143 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 154..189 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <196..>317 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 196..239 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 254..290 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..341 /gene="BUB3" /locus_tag="YOR026W" /gene_synonym="PAC9" /coded_by="NM_001183445.1:1..1026" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:27170178]" /experiment="EXISTENCE:direct assay:GO:0033597 mitotic checkpoint complex [PMID:11726501]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:21070969]" /experiment="EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:22940250]" /experiment="EXISTENCE:genetic interaction:GO:0044774 mitotic DNA integrity checkpoint signaling [PMID:16651657]" /experiment="EXISTENCE:physical interaction:GO:0033597 mitotic checkpoint complex [PMID:11726501|PMID:10704439]" /note="Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; functions at kinetochore to activate APC/C-Cdc20p for normal mitotic progression" /db_xref="GeneID:854191" /db_xref="SGD:S000005552" ORIGIN 1 mqivqieqap kdyisdikii pskslllits wdgsltvykf diqaknvdll qslrykhpll 61 ccnfidntdl qiyvgtvqge ilkvdligsp sfqaltnnea nlgicricky gddkliaasw 121 dglievidpr nygdgviavk nlnsnntkvk nkiftmdtns srlivgmnns qvqwfrlplc 181 eddngtiees glkyqirdva llpkeqegya cssidgrvav effddqgddy nsskrfafrc 241 hrlnlkdtnl aypvnsiefs prhkflytag sdgiiscwnl qtrkkiknfa kfnedsvvki 301 acsdnilcla tsddtfktna aidqtielna ssiyiifdye n // LOCUS NP_014670 589 aa linear PLN 30-JUN-2025 DEFINITION Hsp90 cochaperone STI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014670 VERSION NP_014670.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183446.1 REFERENCE 1 (residues 1 to 589) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 589) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 589) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 589) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 589) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10809. Method: conceptual translation. FEATURES Location/Qualifiers source 1..589 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..589 /product="Hsp90 cochaperone STI1" /calculated_mol_wt="66134" Region 5..>110 /region_name="Spy" /note="Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; COG3914" /db_xref="CDD:443119" Region 5..33 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(6,9..10,13..14,16,41,44..45,48..49,51..52,75,78..79, 82..83,86) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 39..69 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 74..102 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 138..193 /region_name="STI1" /note="STI1 domain; pfam17830" /db_xref="CDD:436075" Region 262..290 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(263,266..267,270..271,273,296,299..300,303..304, 306..307,337,340..341,344..345,348) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 267..515 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 294..324 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 336..363 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 396..424 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(397,400..401,404..405,407,431,434..435,438..439, 441..442,465,468..469,472..473,476) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 429..459 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 464..490 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 527..581 /region_name="STI1" /note="STI1 domain; pfam17830" /db_xref="CDD:436075" CDS 1..589 /gene="STI1" /locus_tag="YOR027W" /coded_by="NM_001183446.1:1..1770" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:39739753]" /experiment="EXISTENCE:direct assay:GO:0030544 Hsp70 protein binding [PMID:12716905]" /experiment="EXISTENCE:direct assay:GO:0042030 ATPase inhibitor activity [PMID:21170051]" /experiment="EXISTENCE:direct assay:GO:0051879 Hsp90 protein binding [PMID:12525481|PMID:9927435]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:8972212]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:27412066]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:24109600]" /experiment="EXISTENCE:physical interaction:GO:0005737 cytoplasm [PMID:12525481]" /note="Evolutionarily-conserved Hsp90 cochaperone; regulates spatial organization of amyloid-like proteins in the cytosol, thereby buffering the proteotoxicity caused by amyloid-like proteins; interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop" /db_xref="GeneID:854192" /db_xref="SGD:S000005553" ORIGIN 1 msltadeykq qgnaaftakd ydkaielftk aievsetpnh vlysnrsacy tslkkfsdal 61 ndanecvkin pswskgynrl gaahlglgdl deaesnykka leldasnkaa kegldqvhrt 121 qqarqaqpdl gltqlfadpn lienlkknpk tsemmkdpql vakligykqn pqaigqdlft 181 dprlmtimat lmgvdlnmdd inqsnsmpke petsksteqk kdaepqsdst tskensskap 241 qkeeskesep mevdeddski eadkekaegn kfykarqfde aiehynkawe lhkditylnn 301 raaaeyekge yetaistlnd aveqgremra dykvisksfa rignayhklg dlkktieyyq 361 ksltehrtad iltklrnaek elkkaeaeay vnpekaeear legkeyftks dwpnavkayt 421 emikrapeda rgysnraaal aklmsfpeai adcnkaiekd pnfvrayirk ataqiavkey 481 asaletldaa rtkdaevnng ssareidqly ykasqqrfqp gtsnetpeet yqramkdpev 541 aaimqdpvmq silqqaqqnp aalqehmknp evfkkiqtli aagiirtgr // LOCUS NP_014671 295 aa linear PLN 30-JUN-2025 DEFINITION Cin5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014671 VERSION NP_014671.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183447.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10810. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..295 /product="Cin5p" /calculated_mol_wt="32844" Region 239..294 /region_name="bZIP_1" /note="bZIP transcription factor; pfam00170" /db_xref="CDD:395118" Site order(239,243..244,246..248,250..251,254..255,257..258) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:269836" Region 242..295 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:269836" Site order(261..262,265..266,268..269,272..273,275..276,279, 282..283,286..287,290,293..294) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:269836" CDS 1..295 /gene="CIN5" /locus_tag="YOR028C" /gene_synonym="HAL6; YAP4" /coded_by="NM_001183447.1:1..888" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11179441|PMID:19029946]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19029946]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:9372930|PMID:20802496|PMID:19111667]" /experiment="EXISTENCE:direct assay:GO:0140297 DNA-binding transcription factor binding [PMID:21552514]" /experiment="EXISTENCE:genetic interaction:GO:0006972 hyperosmotic response [PMID:19774548]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:9593122|PMID:11179441|PMID:15821130]" /experiment="EXISTENCE:mutant phenotype:GO:0042538 hyperosmotic salinity response [PMID:9559673]" /note="Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication" /db_xref="GeneID:854193" /db_xref="SGD:S000005554" ORIGIN 1 mlmqikmdnh pfnfqpilas hsmtrdstkp kkmtdtafvp sppvgfikee nkadlhtisv 61 vasnvtlpqi qlpkiatlee pgyesrtgsl tdlsgrrnsv nigalcedvp ntagphiarp 121 vtinnlipps lprlntyqlr pqlsdthlnc hfnsnpytta shapfessyt tastftsqpa 181 asyfpsnstp atrknsattn lpseerrrvs vslseqvfne gerynndgql igktgkplrn 241 tkraaqnrsa qkafrqrrek yiknleeksk lfdglmkens elkkmieslk sklke // LOCUS NP_001335815 111 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR029W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335815 VERSION NP_001335815.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348877.1 REFERENCE 1 (residues 1 to 111) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 111) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 111) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 111) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 111) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80335. Method: conceptual translation. FEATURES Location/Qualifiers source 1..111 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..111 /product="uncharacterized protein" /calculated_mol_wt="12790" CDS 1..111 /locus_tag="YOR029W" /coded_by="NM_001348877.1:1..336" /note="hypothetical protein; conserved among S. cerevisiae strains; YOR029W is not an essential gene" /db_xref="GeneID:854194" /db_xref="SGD:S000005555" ORIGIN 1 mmqtstssrv rrypyqitls lvlkgfysps apsydfclvl lptlflidlm pikfslhvti 61 gigeatpvpi fffsapwyfr sgnplphcvr ayrckvnfpf frlgwstwlh y // LOCUS NP_014673 619 aa linear PLN 30-JUN-2025 DEFINITION Dfg16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014673 VERSION NP_014673.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183449.1 REFERENCE 1 (residues 1 to 619) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 619) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 619) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 619) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10811. Method: conceptual translation. FEATURES Location/Qualifiers source 1..619 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..619 /product="Dfg16p" /calculated_mol_wt="71599" Region 86..459 /region_name="PalH" /note="PalH/RIM21; pfam08733" /db_xref="CDD:400879" CDS 1..619 /gene="DFG16" /locus_tag="YOR030W" /gene_synonym="ECM41; ZRG12" /coded_by="NM_001183449.1:1..1860" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:23019326]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:9055077]" /experiment="EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:15879523]" /note="Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p" /db_xref="GeneID:854195" /db_xref="SGD:S000005556" ORIGIN 1 miirlhfyyl ltlvyhlglv gayekaarkr iqppdlipgp pghklgderp phydhrppyk 61 khidnipayn ltdliddkll nkyensctvn vltggfisla snswhlrayn ytlnypsfli 121 rcdngsanpn fshvlqdfvy dinnkfnvqd dsskyigkdp fplgmimitf asgcicvatw 181 mlflvvlllp sdnhnrrnkv vhvyvlfsai irtvflneti avifdsqyhd dyqdasqfes 241 fivetapyki celvanilsd inwiyivhyl qsnygkptwn wipfkmkkgt hiiitvgcfl 301 sladnilfan llwrknlvvl kvfykliell iytifisiic yftwhnfayi llpktaeint 361 dgkcktklri lwenyhetip llaynilifi lfyfttiffa aftkhvrgwt fnfvhllkvl 421 itvnvwglig vlekrelhis kktvlgrkin nrdkffanpt vnyygedlgk hlsaitlnrd 481 lnttksntts hdssslvgsp sptwkspier irdrrrrhki mksenkfgqn psfgsksngk 541 pntkttlsky rqllrkprrk tnsyepkngi gqnkegstvr pgadkhirds nylatdisdn 601 esmetelrtn hiynyensd // LOCUS NP_014675 434 aa linear PLN 30-JUN-2025 DEFINITION Hms1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014675 VERSION NP_014675.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183451.1 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10813. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..434 /product="Hms1p" /calculated_mol_wt="48740" Region 265..363 /region_name="bHLHzip_scHMS1_like" /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae transcription factor HMS1 and similar proteins; cd11399" /db_xref="CDD:381405" Site order(268,270..272,274..275,277..279,283,326..327) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:381405" Site order(278,281..282,285..286,288..289,292,327..328,331..332, 335,337..339,341..342,344..345,348..349,351..352,355..356) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:381405" CDS 1..434 /gene="HMS1" /locus_tag="YOR032C" /coded_by="NM_001183451.1:1..1305" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:39756762]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:9832522]" /note="Core promoter binding basic helix-loop-helix bHLH protein; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant; similarity to myc-family transcription factors" /db_xref="GeneID:854197" /db_xref="SGD:S000005558" ORIGIN 1 mpnfqkpfsg ssdgnsvmnd lgnkvaikvf dcrsaqdgse eqnvnvttnq mylmfqsnny 61 nvpppnynte dlgsqgppth ayyapfqhpi hlqppvppvy knntysatdq ysdssfpnts 121 ghtpvidsny yndalasipt tttgsttmtt dngntidsee yidnmevfss eenenidnvk 181 qtdlksekds sllsaasivk keqlsgfenf lplsktespl vtadeikssl nlenidnads 241 msfklktspi rkhfhvkpkr itrvrtgrvs hniiekkyrs nindkieqlr rtvptlrvay 301 kkcndlpits rdladldgle patklnkasi ltksieyich lerkclqlsl anqhlsndtr 361 dsfvhlteps qplsdnssse qvqkqtrscq rqrqrqprqq qplhniqyni phqnglmsgt 421 nnshdmdfnn agdf // LOCUS NP_878169 66 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR032W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878169 VERSION NP_878169.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184624.1 REFERENCE 1 (residues 1 to 66) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 66) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 66) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 66) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 66) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10814. Method: conceptual translation. FEATURES Location/Qualifiers source 1..66 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..66 /product="uncharacterized protein" /calculated_mol_wt="7578" CDS 1..66 /locus_tag="YOR032W-A" /coded_by="NM_001184624.1:1..201" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466481" /db_xref="SGD:S000028710" ORIGIN 1 mrralfiagq tylwlnlthl llifswsstm afsqsrrllt ptvpcptllg idflilvlrh 61 fdeifi // LOCUS NP_014676 702 aa linear PLN 30-JUN-2025 DEFINITION Rad2 family nuclease EXO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014676 VERSION NP_014676.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183452.1 REFERENCE 1 (residues 1 to 702) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 702) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 702) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 702) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 702) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10815. Method: conceptual translation. FEATURES Location/Qualifiers source 1..702 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..702 /product="Rad2 family nuclease EXO1" /calculated_mol_wt="80032" Region 1..202 /region_name="PIN_EXO1" /note="FEN-like PIN domains of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs; cd09857" /db_xref="CDD:350207" Site order(2..4,7..8,30,32..33,36..37,40..41,54,58,78,85,89,92, 95..96,117,120..121,150,152,170..173,185) /site_type="active" /db_xref="CDD:350207" Site order(84..109,111..127) /site_type="other" /note="helical arch" /db_xref="CDD:350207" Region 215..287 /region_name="H3TH_EXO1" /note="H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease; cd09908" /db_xref="CDD:188628" Site order(224..229,231..236,238..241) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:188628" Site 227 /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:188628" Region <267..520 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" CDS 1..702 /gene="EXO1" /locus_tag="YOR033C" /gene_synonym="DHS1" /coded_by="NM_001183452.1:1..2109" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0008409 5'-3' exonuclease activity [PMID:12531018]" /experiment="EXISTENCE:direct assay:GO:0017108 5'-flap endonuclease activity [PMID:12531018]" /experiment="EXISTENCE:genetic interaction:GO:0000706 meiotic DNA double-strand break processing [PMID:20150422]" /experiment="EXISTENCE:genetic interaction:GO:0000723 telomere maintenance [PMID:15126387|PMID:19595717]" /experiment="EXISTENCE:genetic interaction:GO:0000729 DNA double-strand break processing [PMID:17347674|PMID:18805091|PMID:21841787]" /experiment="EXISTENCE:genetic interaction:GO:0031860 telomeric 3' overhang formation [PMID:20808892]" /experiment="EXISTENCE:genetic interaction:GO:0044818 mitotic G2/M transition checkpoint [PMID:18805091]" /experiment="EXISTENCE:mutant phenotype:GO:0000729 DNA double-strand break processing [PMID:17347674]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:11438669]" /experiment="EXISTENCE:mutant phenotype:GO:0007534 gene conversion at mating-type locus [PMID:18806779]" /note="5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication" /db_xref="GeneID:854198" /db_xref="SGD:S000005559" ORIGIN 1 mgiqgllpql kpiqnpvslr ryegevlaid gyawlhraac scayelamgk ptdkylqffi 61 krfsllktfk vepylvfdgd aipvkkstes krrdkrkenk aiaerlwacg ekknamdyfq 121 kcvditpema kciicyckln giryivapfe adsqmvyleq knivqgiise dsdllvfgcr 181 rlitklndyg ecleicrdnf iklpkkfplg sltneeiitm vclsgcdytn gipkvglita 241 mklvrrfnti eriilsiqre gklmipdtyi neyeaavlaf qfqrvfcpir kkivslneip 301 lylkdteskr krlyacigfv ihretqkkqi vhfdddidhh lhlkiaqgdl npydfhqpla 361 nrehklqlas ksniefgktn ttnseakvkp iesffqkmtk ldhnpkvann ihslrqaedk 421 ltmaikrrkl snanvvqetl kdtrskffnk psmtvvenfk ekgdsiqdfk edtnsqslee 481 pvsesqlstq ipssfittnl edddnlseev sevvsdieed rknsegktig neiyntdddg 541 dgdtsedyse taesrvptss ttsfpgssqr sisgctkvlq kfrysssfsg vnanrqplfp 601 rhvnqksrgm vyvnqnrddd cddndgknqi tqrpslrksl igarsqrivi dmksvderks 661 fnsspilhee skkrdiettk ssqarpavrs isllsqfvyk gk // LOCUS NP_014677 749 aa linear PLN 30-JUN-2025 DEFINITION putative palmitoyltransferase AKR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014677 VERSION NP_014677.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183453.1 REFERENCE 1 (residues 1 to 749) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 749) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 749) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 749) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10816. Method: conceptual translation. FEATURES Location/Qualifiers source 1..749 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..749 /product="putative palmitoyltransferase AKR2" /EC_number="2.3.1.225" /calculated_mol_wt="85105" Region 6..292 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 54..81 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(55..56,59..61,63..64,68,71,81,83,85,89..90,93..95, 97..98,102,105,115,117,119,123..124,127..129,131..132,136, 139,148) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 83..115 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 117..148 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 189..220 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 222..247 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 340..711 /region_name="COG5273" /note="Uncharacterized protein containing DHHC-type Zn finger [General function prediction only]" /db_xref="CDD:227598" CDS 1..749 /gene="AKR2" /locus_tag="YOR034C" /coded_by="NM_001183453.1:1..2250" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:16647879]" /note="Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication" /db_xref="GeneID:854199" /db_xref="SGD:S000005560" ORIGIN 1 mtsmsiidde nvkktsngaa vvtdvaqhav sdsdnnkaql lgdgsnteyv vdifieaakd 61 gdlkvvkdvv esgavdinnd ridelsglhw acinnrfsva kflllrganp nqaagpggat 121 alhwaarygn iyivdlllkh gadptlkdeq glnimhfsvy ssnillvvyv lyfvvnnndn 181 vdidskdnnn rtpllwaayq gdfltvelll kfgstvawtd nrgfnalhca lvggdqrvic 241 dlilsganfy ernnqkqdcf dlaegmgtks lfeqalqhhg ydrlgnqkdk lfkksshaqf 301 tiflspfllm vyiylislvl spvlaimlsl lvtvvmvntl kkfvlpclpr kntykvsltr 361 tpffsglfls tfcfliyiwt kklypysvsd ytmknvqflv tsfltvvlfl rlvrsdpgcl 421 ktddsltsiq etikqlidlg kfdrenfcve tlerkplrsk ysffsgalva rydhycpwiy 481 ndvglknhkl fvffavtvqy hmflfmwlcl ayfkktnyiy eqveeyarca llknetlckg 541 snydpstffl fiwisvnfiw lgamlivqff qilkgittpe lfilikeehk akfinlipfe 601 nsiytseskg vedsdmipeg psattithti sidgleprnr rrailsacfs mmginqwlvt 661 ikeivgithi lhgqvpqqhh ssllrsflvt nhwktnltdf wlnsdvtapl wqrffyssdt 721 skamlggtev dyyelyeypa regevlrpn // LOCUS NP_878170 80 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR034C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878170 VERSION NP_878170.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184667.1 REFERENCE 1 (residues 1 to 80) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 80) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 80) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 80) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 80) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10817. Method: conceptual translation. FEATURES Location/Qualifiers source 1..80 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..80 /product="uncharacterized protein" /calculated_mol_wt="9647" CDS 1..80 /locus_tag="YOR034C-A" /coded_by="NM_001184667.1:1..243" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466482" /db_xref="SGD:S000028856" ORIGIN 1 mntqelckif vareyplvvv pfiyfvlflh qkyhttlnyv wyptcskriw vrekgrkcsf 61 fffskvprsd gfannrcqrk // LOCUS NP_014678 789 aa linear PLN 30-JUN-2025 DEFINITION She4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014678 VERSION NP_014678.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183454.1 REFERENCE 1 (residues 1 to 789) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 789) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 789) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 789) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 789) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 789) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 789) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 789) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 789) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10818. Method: conceptual translation. FEATURES Location/Qualifiers source 1..789 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..789 /product="She4p" /calculated_mol_wt="89422" Region 167..316 /region_name="UNC45-central" /note="Myosin-binding striated muscle assembly central; pfam11701" /db_xref="CDD:432011" CDS 1..789 /gene="SHE4" /locus_tag="YOR035C" /gene_synonym="DIM1" /coded_by="NM_001183454.1:1..2370" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8625407]" /experiment="EXISTENCE:direct assay:GO:0017022 myosin binding [PMID:12725728]" /experiment="EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:8625407]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:11553699]" /note="Protein containing a UCS (UNC-45/CRO1/SHE4) domain; binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization" /db_xref="GeneID:854200" /db_xref="SGD:S000005561" ORIGIN 1 mplcekgndp idsstidslc aafdktlkst pdvqkyndai ntifqlrqks esgkmpadlt 61 nsealkdrqk ieeiltrsyq dhsesrvhls kliqndipfa lnlfeilsrs sihvfvgcfs 121 nkdatialln elqirihyge dthvtyllsi ilqllnkfky nfkevrflvk elilrisede 181 vksmmliifa elqssfqkdf dkavvdfmss liveaeidvg ndplsiivkt lselypsltt 241 lcseifltkg lsklfkkrvf eeqdlqftke llrllssaci detmrtyite nylqllersl 301 nvedvqiysa lvlvktwsft kltcinlkql seifinaisr rimpkienvn esavkleevp 361 kvemsveala ylslkasvki mirsnesfte illtmiksqk mthclygllv imanlstlpe 421 esngssqsin dlknyadlkg pgadkvgaek eskedillfn ekyilrteli sflkremhnl 481 spnckqqvvr viynitrskn fipqcisqgg ttiileylan kqdigepiri lgcraltrml 541 iftnpglifk kysalnaipf lfellprstp vddnplhnde qikltdnyea llaltnlass 601 etsdgeevck hivstkvyws tienlmlden vplqrstlel isnmmshplt iaakffnlen 661 pqslrnfnil vkllqlsdve sqravaaifa niattiplia kelltkkeli enaiqvfadq 721 iddielrqrl lmlffglfev ipdngtnevy pllqenqklk dalnmslkrg dsgpefsaai 781 pvilakikv // LOCUS NP_014679 288 aa linear PLN 30-JUN-2025 DEFINITION SNAP receptor PEP12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014679 VERSION NP_014679.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183455.1 REFERENCE 1 (residues 1 to 288) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 288) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 288) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 288) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10819. Method: conceptual translation. FEATURES Location/Qualifiers source 1..288 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..288 /product="SNAP receptor PEP12" /calculated_mol_wt="32875" Region 4..288 /region_name="COG5325" /note="t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]" /db_xref="CDD:227635" CDS 1..288 /gene="PEP12" /locus_tag="YOR036W" /gene_synonym="VPL6; VPS6; VPT13" /coded_by="NM_001183455.1:1..867" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:14981247]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]" /experiment="EXISTENCE:mutant phenotype:GO:0005484 SNAP receptor activity [PMID:8730101]" /experiment="EXISTENCE:mutant phenotype:GO:0005768 endosome [PMID:8730101]" /experiment="EXISTENCE:mutant phenotype:GO:0005794 Golgi apparatus [PMID:8730101]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:8730101]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:19793921]" /note="Target membrane receptor (t-SNARE); for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin" /db_xref="GeneID:854201" /db_xref="SGD:S000005562" ORIGIN 1 msedeffggd neavwngsrf sdspefqtlk eevaaelfei ngqistlqqf tatlksfidr 61 gdvsakvver inkrsvakie eigglikkvn tsvkkmdaie easldktqii areklvrdvs 121 ysfqefqgiq rqftqvmkqv nerakeslea semandaall deeqrqnssk stripgsqiv 181 ierdpinnee fayqqnlieq rdqeisnier gitelnevfk dlgsvvqqqg vlvdnieani 241 yttsdntqla sdelrkamry qkrtsrwrvy llivllvmll fiflimkl // LOCUS NP_014680 366 aa linear PLN 30-JUN-2025 DEFINITION oxidoreductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014680 VERSION NP_014680.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183456.1 REFERENCE 1 (residues 1 to 366) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 366) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 366) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 366) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 366) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10820. On Oct 2, 2003 this sequence version replaced NP_014680.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..366 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..366 /product="oxidoreductase" /calculated_mol_wt="42237" Region 68..365 /region_name="cyt_b5_reduct_like" /note="Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a...; cd06183" /db_xref="CDD:99780" Site order(106,118..121,150..152,154,156..160,229,232..233,365) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99780" Site order(118,120..121) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99780" Site order(152,154,229..230,253..255,283,295,328..332) /site_type="other" /note="NAD binding pocket [chemical binding]" /db_xref="CDD:99780" Site order(157,160,163,169,177,179) /site_type="other" /note="phosphate binding motif [ion binding]" /db_xref="CDD:99780" Site order(224,228..231,233) /site_type="other" /note="beta-alpha-beta structure motif" /db_xref="CDD:99780" CDS 1..366 /gene="CYC2" /locus_tag="YOR037W" /coded_by="NM_001183456.1:1..1101" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:11914276|PMID:14562095|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16207709]" /experiment="EXISTENCE:direct assay:GO:0016491 oxidoreductase activity [PMID:16207709]" /experiment="EXISTENCE:genetic interaction:GO:0018063 cytochrome c-heme linkage [PMID:14514677|PMID:16207709]" /experiment="EXISTENCE:mutant phenotype:GO:0007006 mitochondrial membrane organization [PMID:11488609]" /note="Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)" /db_xref="GeneID:854202" /db_xref="SGD:S000005563" ORIGIN 1 mlwknyvlss sritrrlhks prkssfsknf fitgclltvg avssyltyry tserenkhel 61 spsyfvkyki shkrdidssh fllevtplfk qkvniwslmt aenlwsveik qpevmvvrny 121 tplplkfnpa skeieilkdg dnadgklsfy ikkyengeva rwlhhlpkgh iieirgpfid 181 yefphlpnel krsrdclymd nrnergnnvr ensqfiyqpy dimmftagtg ivtalqlllt 241 espfrgtikl fhtdknikql gplypillrl qasnrvqlki fetdrqtkqd vlksiqksit 301 kpypykgllp fsnvnnknim pvlalvcgpe syissisgrk ydlnqgpvgg llskegwnsd 361 nvykls // LOCUS NP_014681 875 aa linear PLN 30-JUN-2025 DEFINITION Hir2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014681 VERSION NP_014681.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183457.1 REFERENCE 1 (residues 1 to 875) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 875) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 875) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 875) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 875) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10821. Method: conceptual translation. FEATURES Location/Qualifiers source 1..875 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..875 /product="Hir2p" /calculated_mol_wt="98314" Region 123..163 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 169..207 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <172..350 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 268..318 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 581..824 /region_name="Hira" /note="TUP1-like enhancer of split; pfam07569" /db_xref="CDD:462211" CDS 1..875 /gene="HIR2" /locus_tag="YOR038C" /gene_synonym="SPT1" /coded_by="NM_001183457.1:1..2628" /experiment="EXISTENCE:direct assay:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9001207]" /experiment="EXISTENCE:direct assay:GO:0000417 HIR complex [PMID:16264190|PMID:16303565]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:16264190]" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9001207]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8417331|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:16264190|PMID:16303565]" /experiment="EXISTENCE:genetic interaction:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:23962978]" /experiment="EXISTENCE:genetic interaction:GO:0140673 transcription elongation-coupled chromatin remodeling [PMID:16449659]" /experiment="EXISTENCE:mutant phenotype:GO:0016480 negative regulation of transcription by RNA polymerase III [PMID:23962978]" /experiment="EXISTENCE:mutant phenotype:GO:0031491 nucleosome binding [PMID:16264190]" /experiment="EXISTENCE:physical interaction:GO:0000417 HIR complex [PMID:16264190]" /note="Subunit of HIR nucleosome assembly complex; involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:854203" /db_xref="SGD:S000005564" ORIGIN 1 mrllkypldi hneqvnalaa lgpyiilags gghvmawrqq qlvdtafdrv mikdlkpevs 61 fqvdqdttgd iffitgdlet lyigsehrlw gysgwlcrdt nninsvekmn skllfecksp 121 stitdvkydi nlgilfvlls nenkillfrh ktfdklseit idkaskpitg iidptgqtft 181 vmtsdrsilv yqinktgthk linkltqhvq myplhyrism spqadilpvi nsvkgvpnna 241 tsctalldrn nnykvtktlv tpssngcrvl vyspafyekp nlkkgtstry nliatsgstd 301 gtilvwntkr mkplfnalqv sstaindmsw sqdgftlfai sndatlytfa fqekdlgval 361 pqteikslqe vnkklpklee plaeqipksf penikleesa saapipndig rsavgkkptk 421 kktannqtng iktiqstsme fntpsytvpr dlkrkpkeat psniapgskk qkkelqpidf 481 ldtglllpnt sfsrirlatp kirstfkysp innpnlildv kngsgneqrp tivkltskvl 541 dqdqvlfqdf ipkliticta gdtfwsfcse dgsiyiysds grklmaplvl gvsisfleac 601 gtyllcltsi gelycwnieq kklafptnti ypllnpslry sddiltraen itlcsitkkg 661 vplvtlsngd gylfdknmet wllvsdgwwa ygsqywdttn ttglssskan tdsfngsesn 721 ineivsdikn dnqsiinfle cktndelnrk griknlqrfa rtilmkegfe nmeeivtlsh 781 lenkilisir leepeefskl mmvycirlse lgymdrlndv fqwlyddlpi sgtgsafadk 841 dfkrnllkki liacgdirqv qrvttryake mniis // LOCUS NP_014682 258 aa linear PLN 30-JUN-2025 DEFINITION casein kinase 2 regulatory subunit CKB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014682 VERSION NP_014682.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183458.1 REFERENCE 1 (residues 1 to 258) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 258) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 258) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 258) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10822. Method: conceptual translation. FEATURES Location/Qualifiers source 1..258 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..258 /product="casein kinase 2 regulatory subunit CKB2" /calculated_mol_wt="29711" Region 12..258 /region_name="SKB2" /note="Casein kinase II, beta subunit [Signal transduction mechanisms / Cell division and chromosome partitioning / Transcription]; COG5041" /db_xref="CDD:227374" CDS 1..258 /gene="CKB2" /locus_tag="YOR039W" /coded_by="NM_001183458.1:1..777" /experiment="EXISTENCE:direct assay:GO:0005956 protein kinase CK2 complex [PMID:8135547]" /experiment="EXISTENCE:direct assay:GO:0006356 regulation of transcription by RNA polymerase I [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0006359 regulation of transcription by RNA polymerase III [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0006974 DNA damage response [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0030291 protein serine/threonine kinase inhibitor activity [PMID:18265947]" /experiment="EXISTENCE:direct assay:GO:0032545 CURI complex [PMID:17452446]" /experiment="EXISTENCE:direct assay:GO:0034456 UTP-C complex [PMID:17515605]" /experiment="EXISTENCE:mutant phenotype:GO:0019887 protein kinase regulator activity [PMID:11827175]" /note="Beta' regulatory subunit of casein kinase 2 (CK2); a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase" /db_xref="GeneID:854204" /db_xref="SGD:S000005565" ORIGIN 1 mgsrsenvgt vtregsrveq ddvlmdddsd sseyvdmwid lflgrkghey fcdvdpeyit 61 drfnlmnlqk tvskfsyvvq yivddlddsi lenmtharle qlesdsrkly gliharyiit 121 ikglqkmyak ykeadfgrcp rvycnlqqll pvglhdipgi dcvklycpsc edlyipkssr 181 hssidgayfg tsfpgmflqa fpdmvpkhpt kryvpkifgf elhkqaqltr wqelqrlklv 241 ekleskdvdl tksggfkt // LOCUS NP_014683 285 aa linear PLN 30-JUN-2025 DEFINITION hydroxyacylglutathione hydrolase GLO4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014683 VERSION NP_014683.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183459.1 REFERENCE 1 (residues 1 to 285) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 285) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 285) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 285) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10823. Method: conceptual translation. FEATURES Location/Qualifiers source 1..285 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..285 /product="hydroxyacylglutathione hydrolase GLO4" /EC_number="3.1.2.6" /calculated_mol_wt="32208" Region 18..198 /region_name="hydroxyacylglutathione_hydrolase_MBL-fold" /note="hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain; cd07723" /db_xref="CDD:293809" Site order(69,71,73..74,131,154,157,161,163,198) /site_type="active" /db_xref="CDD:293809" Region 199..285 /region_name="HAGH_C" /note="Hydroxyacylglutathione hydrolase C-terminus; pfam16123" /db_xref="CDD:465030" CDS 1..285 /gene="GLO4" /locus_tag="YOR040W" /coded_by="NM_001183459.1:1..858" /experiment="EXISTENCE:direct assay:GO:0004416 hydroxyacylglutathione hydrolase activity [PMID:9261170]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:9261170]" /experiment="EXISTENCE:direct assay:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:9261170]" /experiment="EXISTENCE:genetic interaction:GO:0004416 hydroxyacylglutathione hydrolase activity [PMID:9261170]" /experiment="EXISTENCE:genetic interaction:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:9261170]" /experiment="EXISTENCE:mutant phenotype:GO:0004416 hydroxyacylglutathione hydrolase activity [PMID:9261170]" /experiment="EXISTENCE:mutant phenotype:GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione [PMID:9261170]" /note="Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication" /db_xref="GeneID:854205" /db_xref="SGD:S000005566" ORIGIN 1 mkfllqqirn mhvkpikmrw ltggvnysyl lstedrrnsw lidpaeplev spklsaeekk 61 sidaivnthh hydhsggnla lysilcqens ghdikiiggs ksspgvtevp dnlqqyhlgn 121 lrvtcirtpc htkdsicyyi kdletgeqci ftgdtlfiag cgrffegtgr dmdmalnqim 181 lravgetnwn kvkiypghey tkgnvsfira kiysdigqnk efdaleqyck snecttghft 241 lrdelgynpf mrlddravrl avgdtagtyp rsvvmqelrk lknam // LOCUS NP_014685 411 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-binding protein CUE5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014685 VERSION NP_014685.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183461.1 REFERENCE 1 (residues 1 to 411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 411) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10824. Method: conceptual translation. FEATURES Location/Qualifiers source 1..411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..411 /product="ubiquitin-binding protein CUE5" /calculated_mol_wt="46739" Region 97..141 /region_name="CUE_Cue5p_like" /note="CUE domain found in yeast ubiquitin-binding protein CUE5 (Cue5p), donuts protein 1 (DON1p) and similar proteins; cd14372" /db_xref="CDD:270555" CDS 1..411 /gene="CUE5" /locus_tag="YOR042W" /coded_by="NM_001183461.1:1..1236" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0036435 K48-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:direct assay:GO:0043130 ubiquitin binding [PMID:12628920]" /experiment="EXISTENCE:direct assay:GO:0070530 K63-linked polyubiquitin modification-dependent protein binding [PMID:28525741]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:25042851]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:25042851]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:25042851]" /note="Selective autophagy receptor involved in aggrephagy and proteaphagy; ubiquitin (Ub)-binding protein that functions as a Ub-Atg8p adaptor in Ub-dependent autophagy; serves as a proteaphagy receptor for inactivate 26S proteasomes; contains a CUE domain that binds K48-and K63-linked Ub chains and monoubiquitin, facilitating intramolecular monoubiquitination; human TOLLIP is a functional CUE-domain homolog, that complements a null mutant, rescuing the hypersensitivity of the null mutant to Htt-96Q" /db_xref="GeneID:854206" /db_xref="SGD:S000005568" ORIGIN 1 meekegikds slleksnvpe sinedisktt dvdlnsdgkk dndtsakdgt pkveekvnks 61 sgidedevvt paedakeeee ehpplparrk seeepskenp ilqelkdafp nleekyikav 121 iiasqgvlsp afnallflsd pesgkdielp tqpvrknpea parrrqtqle qdellarqld 181 eqfnsshsrr rnrdratrsm heqrrrrhnp nereqhheds eeedswsqfv ekdlpeltdr 241 agrslqdtan kvsnwisday rrnfasgneq ndnqhghqdq qewepeivdl sqggknsrpq 301 qperrrfnsf gvqvgddsle shgitlhned gfeddedvpp qlptrtksge stgkvvaett 361 yidtpdtetk kkwqplppep ldttptkvna vsrnkknpde deflinsdde m // LOCUS NP_014686 486 aa linear PLN 30-JUN-2025 DEFINITION Whi2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014686 VERSION NP_014686.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183462.1 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10825. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..486 /product="Whi2p" /calculated_mol_wt="55215" Region 42..112 /region_name="BTB_POZ" /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; cl38908" /db_xref="CDD:453885" CDS 1..486 /gene="WHI2" /locus_tag="YOR043W" /coded_by="NM_001183462.1:1..1461" /experiment="EXISTENCE:direct assay:GO:0019903 protein phosphatase binding [PMID:12090248]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0034198 cellular response to amino acid starvation [PMID:30142151]" /experiment="EXISTENCE:genetic interaction:GO:1904262 negative regulation of TORC1 signaling [PMID:30142151]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:21429936]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:15020461]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:15020461]" /experiment="EXISTENCE:mutant phenotype:GO:0034198 cellular response to amino acid starvation [PMID:30142151]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:12090248]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:12090248]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12090248]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:12090248]" /experiment="EXISTENCE:mutant phenotype:GO:1903452 positive regulation of G1 to G0 transition [PMID:7001255]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:30142151]" /note="Negative regulator of TORC1 in response to limiting leucine; suppresses TORC1 activity with binding partners Psr1p/Psr2p, acting in parallel with SEACIT; regulates cell cycle arrest in stationary phase; inhibits Ras-cAMP-PKA regulation of apoptosis during nutrient depletion; required with Psr1p for activation of the general stress response; role in rapamycin-induced mitophagy; localizes to the cell periphery; human tumor suppressor and Whi2-like protein KCTD11 functionally complements the null" /db_xref="GeneID:854208" /db_xref="SGD:S000005569" ORIGIN 1 mddiitqvsp dnaesapilq eqqqqqnsqy egneedygds lihlniqenh yfitrdqlms 61 lpeslllclf psgvfldrcg qvitnltrdd evyivnfppd cfeyimeiyt kahddlynhp 121 vekffdrpss sfvsnakgff glssnnsiss nneqdilhqk paiivlredl dyycvpqeef 181 qfdstneenn edllrhfmaq vkmaagsylt sktsifqgly ssnrlkqqqq qqkiekgsns 241 ssntkstskk lgpaeqhlmd mlcssgftke tcwgnrtqet gktvisslsl crlanetteg 301 frqkfneaka kweaehkpsq dnfitpmqsn isinslsask snstistarn ltsgstapat 361 ardkrksrls kladnvrshs ssrhssqtrs kppelpklyd lvpkpninak lllfwrkpar 421 kcwwgeedie levevfgswk deskkiieli lptnvdpeae lhkiivpvrl hirrvwtlel 481 svigvq // LOCUS NP_014687 157 aa linear PLN 30-JUN-2025 DEFINITION Irc23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014687 VERSION NP_014687.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183463.1 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10826. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..157 /product="Irc23p" /calculated_mol_wt="17961" CDS 1..157 /gene="IRC23" /locus_tag="YOR044W" /coded_by="NM_001183463.1:1..474" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="hypothetical protein involved in multidrug resistance; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci; IRC23 has a paralog, BSC2, that arose from the whole genome duplication" /db_xref="GeneID:854209" /db_xref="SGD:S000005570" ORIGIN 1 miealeivll lviqslqyic rtciafllip flglyafdlf lyvyrmilyl sqmfnykrkl 61 grsktnnrph sprlhkiyss gdcmdtligq vrdlrvflls tihshskrff strfqtksgi 121 nsaidandve ttsdvssftn lhltrsseeg yyiagsi // LOCUS NP_014688 61 aa linear PLN 30-JUN-2025 DEFINITION Tom6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014688 VERSION NP_014688.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183464.1 REFERENCE 1 (residues 1 to 61) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 61) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 61) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 61) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 61) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10827. Method: conceptual translation. FEATURES Location/Qualifiers source 1..61 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..61 /product="Tom6p" /calculated_mol_wt="6276" Region 17..61 /region_name="Tom6" /note="Mitochondrial import receptor subunit Tom6, fungal; pfam17112" /db_xref="CDD:407252" CDS 1..61 /gene="TOM6" /locus_tag="YOR045W" /gene_synonym="ISP6; MOM8B" /coded_by="NM_001183464.1:1..186" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:7565772]" /experiment="EXISTENCE:direct assay:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:20668160]" /experiment="EXISTENCE:mutant phenotype:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9774667|PMID:7565772]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:9774667]" /note="Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex" /db_xref="GeneID:854210" /db_xref="SGD:S000005571" ORIGIN 1 mdgmfampga aagaaspqqp ksrfqafkes plytialnga ffvagvafiq splmdmlapq 61 l // LOCUS NP_014689 482 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase DBP5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014689 VERSION NP_014689.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183465.1 REFERENCE 1 (residues 1 to 482) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 482) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 482) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 482) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 482) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10828. Method: conceptual translation. FEATURES Location/Qualifiers source 1..482 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..482 /product="ATP-dependent RNA helicase DBP5" /EC_number="3.6.4.13" /calculated_mol_wt="53743" Region 93..482 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..482 /gene="DBP5" /locus_tag="YOR046C" /gene_synonym="RAT8" /coded_by="NM_001183465.1:1..1449" /experiment="EXISTENCE:direct assay:GO:0000822 inositol hexakisphosphate binding [PMID:16783363]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:9564047]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15280434]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15280434|PMID:9564048|PMID:10610322]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:19198597]" /experiment="EXISTENCE:direct assay:GO:0006409 tRNA export from nucleus [PMID:31453808]" /experiment="EXISTENCE:direct assay:GO:0008186 ATP-dependent activity, acting on RNA [PMID:19805289]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:27251550]" /experiment="EXISTENCE:direct assay:GO:0044614 nuclear pore cytoplasmic filaments [PMID:10610322]" /experiment="EXISTENCE:genetic interaction:GO:0006415 translational termination [PMID:17272721]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:9564048]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:27385342]" /experiment="EXISTENCE:physical interaction:GO:0006415 translational termination [PMID:17272721]" /note="Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus, remodeling messenger ribonucleoprotein particles (mRNPs), with ATPase activity stimulated by Gle1p, IP6 and Nup159p; involved in translation termination along with Sup45p (eRF1); role in the cellular response to heat stress" /db_xref="GeneID:854211" /db_xref="SGD:S000005572" ORIGIN 1 msdtkrdpad llaslkidne kedtsevstk etvksqpekt adsikpaekl vpkveekktk 61 qedsnlisse yevkvkladi qadpnsplys aksfdelgla pellkgiyam kfqkpskiqe 121 ralplllhnp prnmiaqsqs gtgktaafsl tmltrvnped aspqaiclap srelarqtle 181 vvqemgkftk itsqlivpds feknkqinaq vivgtpgtvl dlmrrklmql qkikifvlde 241 adnmldqqgl gdqcirvkrf lpkdtqlvlf satfadavrq yakkivpnan tlelqtnevn 301 vdaikqlymd ckneadkfdv ltelyglmti gssiifvatk ktanvlygkl kseghevsil 361 hgdlqtqerd rliddfregr skvlittnvl argidiptvs mvvnydlptl angqadpaty 421 ihrigrtgrf grkgvaisfv hdknsfnils aiqkyfgdie mtrvptddwd evekivkkvl 481 kd // LOCUS NP_014690 444 aa linear PLN 30-JUN-2025 DEFINITION Std1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014690 VERSION NP_014690.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183466.1 REFERENCE 1 (residues 1 to 444) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 444) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 444) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 444) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 444) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10829. Method: conceptual translation. FEATURES Location/Qualifiers source 1..444 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..444 /product="Std1p" /calculated_mol_wt="50130" Region 154..344 /region_name="STD1" /note="STD1/MTH1; pfam17235" /db_xref="CDD:435802" CDS 1..444 /gene="STD1" /locus_tag="YOR047C" /gene_synonym="MSN3; SFS3" /coded_by="NM_001183466.1:1..1335" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10373505]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10373505]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:12618390]" /experiment="EXISTENCE:genetic interaction:GO:0071590 nicotinamide riboside biosynthetic process [PMID:19846558]" /experiment="EXISTENCE:genetic interaction:GO:0071592 nicotinic acid riboside biosynthetic process [PMID:19846558]" /experiment="EXISTENCE:mutant phenotype:GO:0006006 glucose metabolic process [PMID:10373505]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:7667094]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:10373505]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:9725828]" /experiment="EXISTENCE:mutant phenotype:GO:0071590 nicotinamide riboside biosynthetic process [PMID:19846558]" /experiment="EXISTENCE:mutant phenotype:GO:0071592 nicotinic acid riboside biosynthetic process [PMID:19846558]" /note="Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+]; STD1 has a paralog, MTH1, that arose from the whole genome duplication" /db_xref="GeneID:854212" /db_xref="SGD:S000005573" ORIGIN 1 mfvspppata rnqvlgkrks krhdenpknv qpnadtemtn svpsigfnsn lphnnqeint 61 pnhynlssns gnvrsnnnfv ttppeyadra rieiikrllp tagtkpmevn sntaenaniq 121 hintpdsqsf vsdhsssyes sifsqpstal tdittgssli dtktpkfvte vtledalpkt 181 fydmyspevl msdpanilyn grpkftkrel ldwdlndirs lliveqlrpe wgsqlptvvt 241 sginlpqfrl qllplsssde fiiatlvnsd lyieanldrn fkltsakytv asarkrheem 301 tgskepimrl skpewrniie nyllnvavea qcrydfkqkr seykrwklln snlkrpdmpp 361 psliphgfki hdctnsgsll kkalmknlql knykndaktl gagtqknvvn kvsltseera 421 aiwfqcqtqv yqrlgldwkp dgms // LOCUS NP_014691 1006 aa linear PLN 30-JUN-2025 DEFINITION ssRNA exonuclease RAT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014691 VERSION NP_014691.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183467.1 REFERENCE 1 (residues 1 to 1006) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1006) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1006) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1006) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1006) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1006) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1006) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1006) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1006) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10830. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1006 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1006 /product="ssRNA exonuclease RAT1" /calculated_mol_wt="115803" Region 1..1006 /region_name="XRN1" /note="5'-3' exonuclease [Replication, recombination and repair]; COG5049" /db_xref="CDD:227382" CDS 1..1006 /gene="RAT1" /locus_tag="YOR048C" /gene_synonym="HKE1; TAP1; XRN2" /coded_by="NM_001183467.1:1..3021" /experiment="EXISTENCE:direct assay:GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:26638174]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004534 5'-3' RNA exonuclease activity [PMID:8417335]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:9315672]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0110155 NAD-cap decapping [PMID:35173156]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:9488433]" /experiment="EXISTENCE:genetic interaction:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:19818713]" /experiment="EXISTENCE:genetic interaction:GO:0034244 negative regulation of transcription elongation by RNA polymerase II [PMID:24501251]" /experiment="EXISTENCE:genetic interaction:GO:0043144 sno(s)RNA processing [PMID:9488433]" /experiment="EXISTENCE:genetic interaction:GO:0071028 nuclear mRNA surveillance [PMID:11030620]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:33978753]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:9488433|PMID:11142370]" /experiment="EXISTENCE:mutant phenotype:GO:0030846 termination of RNA polymerase II transcription, poly(A)-coupled [PMID:15565157]" /experiment="EXISTENCE:mutant phenotype:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:19818713]" /experiment="EXISTENCE:mutant phenotype:GO:0034244 negative regulation of transcription elongation by RNA polymerase II [PMID:24501251]" /experiment="EXISTENCE:mutant phenotype:GO:0043144 sno(s)RNA processing [PMID:9488433]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:27124216|PMID:11030620]" /experiment="EXISTENCE:mutant phenotype:GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process [PMID:16131592]" /note="Nuclear 5' to 3' single-stranded RNA exonuclease; involved in RNA metabolism, including rRNA and snoRNA processing, as well as poly (A+) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage; displaces Cdk1p from elongating transcripts, especially as RNAPII reaches the poly(A) site, negatively regulates phosphorylation of the CTD of RNAPII, and inhibits RNAPII transcriptional elongation" /db_xref="GeneID:854213" /db_xref="SGD:S000005574" ORIGIN 1 mgvpsffrwl srkypkiisp vleeqpqivd gvilpldysa snpngeldnl yldmngivhp 61 cshpenkppp etedemllav feytnrvlnm arprkvlvma vdgvaprakm nqqrarrfrs 121 ardaqienea reeimrqree vgeiiddavr nkktwdsnai tpgtpfmdkl aaalrywtaf 181 klatdpgwkn lqviisdatv pgegehkimn firsqradpe ynpntthciy gldadliflg 241 lathephfki lredvfaqdn rkrnnlkdti nmteeekqfl qkqnseqpfl wlhinvlrey 301 lsaelwvpgl pftfdlerai ddwvfmcffc gndflphlpc ldvrensidi lldiwkvvlp 361 klktymtcdg vlnlpsvetl lqhlgsregd ifktrhiqea rkkeaferrk aqknmskgqd 421 rhptvateql qmydtqgnla kgswnlttsd mvrlkkelml anegneeaia kvkqqsdknn 481 elmkdiskee iddavskank tnfnlaevmk qkiinkkhrl ekdneeeeia kdskkvktek 541 aesecdldae ikdeivadvn drensettev srdspvhstv nvsegpkngv fdtdefvklf 601 epgyheryyt akfhvtpqdi eqlrkdmvkc yiegvawvlm yyyqgcaswn wfypyhyapl 661 atdfhgfshl eikfeegtpf lpyeqlmsvl paasghalpk ifrslmsepd seiidfypee 721 fpidmngkkm swqgiallpf idqdrlltav raqypllsda erarnirgep vllisnknan 781 yerfskklys kennnnnvvv kfqhfksgls givskdvegf elngkivcpi qggslpnlst 841 tlilkmsyrl iplpsrnksi ilngfipsep vltaydldsi mykynnqnys rrwnfgndlk 901 qnivpvgpkg itqykprtgg yraffyfael srnnvqpahn ygrnsynsqp gfnnsrydgg 961 nnnyrqnsny rnnnysgnrn sgqysgnsys rnnkqsrydn sranrr // LOCUS NP_014692 354 aa linear PLN 30-JUN-2025 DEFINITION phospholipid-translocating ATPase RSB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014692 VERSION NP_014692.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183468.1 REFERENCE 1 (residues 1 to 354) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 354) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 354) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 354) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 354) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10831. Method: conceptual translation. FEATURES Location/Qualifiers source 1..354 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..354 /product="phospholipid-translocating ATPase RSB1" /calculated_mol_wt="40265" Region 37..283 /region_name="RTA1" /note="RTA1 like protein; pfam04479" /db_xref="CDD:461325" CDS 1..354 /gene="RSB1" /locus_tag="YOR049C" /coded_by="NM_001183468.1:1..1065" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005324 long-chain fatty acid transmembrane transporter activity [PMID:28175317]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12034738]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12034738|PMID:16407254]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:12034738]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:24146988]" /experiment="EXISTENCE:direct assay:GO:1905329 sphingoid long-chain base transport [PMID:12034738]" /experiment="EXISTENCE:mutant phenotype:GO:0045332 phospholipid translocation [PMID:15342785]" /experiment="EXISTENCE:mutant phenotype:GO:1905329 sphingoid long-chain base transport [PMID:12034738]" /note="Sphingoid long-chain base (LCB) efflux transporter; integral membrane transporter that localizes to the plasma membrane and may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane; role in glycerophospholipid translocation; suppressor of the sphingoid LCB sensitivity of an LCB-lyase mutation" /db_xref="GeneID:854214" /db_xref="SGD:S000005575" ORIGIN 1 mvpnlrfnit miviwgillt ihvvqllmrq ywfsiafict gilevlgfig rtwshsnvad 61 mdafllnmic ltiapvftmg giyyqlakli evyghrfsll pspmaysfif icsdivslvv 121 qavggglcgv avtdgtsttt gnhvfiagla iqvasmaifl mlwfhflfri yisvrwehin 181 srpislsllk isqtevdyly rekfhflrle pkrwvfhyfn laitvavlti ftrccyrlae 241 lvvgwdgyli thewyfiild almmaiatvt ltifhpgfaf kgrstsipit pghvdpetlp 301 htddvedild tsdskqfdie keefqasmky pistfkqfms kianlfsskk kakl // LOCUS NP_014694 412 aa linear PLN 30-JUN-2025 DEFINITION Ett1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014694 VERSION NP_014694.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183470.1 REFERENCE 1 (residues 1 to 412) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 412) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 412) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 412) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10832. Method: conceptual translation. FEATURES Location/Qualifiers source 1..412 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..412 /product="Ett1p" /calculated_mol_wt="47221" Region 1..410 /region_name="Nro1" /note="Nuclear pore complex subunit Nro1; pfam12753" /db_xref="CDD:403837" CDS 1..412 /gene="ETT1" /locus_tag="YOR051C" /gene_synonym="NRO1; YOR29-02" /coded_by="NM_001183470.1:1..1239" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26359986|PMID:10684247|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006415 translational termination [PMID:20630870]" /experiment="EXISTENCE:mutant phenotype:GO:0006415 translational termination [PMID:20630870]" /note="Nuclear protein that inhibits replication of Brome mosaic virus; S. cerevisiae is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough" /db_xref="GeneID:854216" /db_xref="SGD:S000005577" ORIGIN 1 makrplglgk qsrekkrkve svekksdeps restpvrsqm sveldddadl ddelaqlkgl 61 wskyfhsdrd deyvlngivh ecdrllrlse edkeikktln difhgiyala lseltifkag 121 deeateekrk kdvssffesa iervelglsh fpesqflklv lakiifqrip leyisnlhlk 181 skdkkldlvg qlehgkkhfs iyendteftf eilqmvndll divenfgreq siqegidsdn 241 eeeeelidie lepehpvypl qqsleanyew lrnhfdklld ntntdvkiya siantlgely 301 lkkaeepskv flslqyddgg sekvsdkeak naqetalkht kkaleyleka kleddpdtwv 361 qvaeayidlg nlldnesaeq eeayktaeei lgkankashg kfqdvldnfl qg // LOCUS NP_014695 150 aa linear PLN 30-JUN-2025 DEFINITION Tmc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014695 VERSION NP_014695.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183471.1 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10833. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..150 /product="Tmc1p" /calculated_mol_wt="16603" Region 88..125 /region_name="ZnF_AN1" /note="AN1-like Zinc finger; smart00154" /db_xref="CDD:197545" CDS 1..150 /gene="TMC1" /locus_tag="YOR052C" /gene_synonym="YOR29-03" /coded_by="NM_001183471.1:1..453" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071218 cellular response to misfolded protein [PMID:27226598]" /experiment="EXISTENCE:direct assay:GO:0071243 cellular response to arsenic-containing substance [PMID:27226598]" /experiment="EXISTENCE:mutant phenotype:GO:0071243 cellular response to arsenic-containing substance [PMID:24297164]" /note="AN1-type zinc finger protein, effector of proteotoxic stress response; stress-inducible transcriptional target of Rpn4p; induced by nitrogen limitation, weak acid, misfolded proteins; short-lived protein, degraded by proteasome; may protect cells from trivalent metalloid induced proteotoxicity; contains PACE promoter element; ortholog of human AIRAP, which stimulates proteasome activity in response to arsenic; protein abundance increases under DNA replication stress" /db_xref="GeneID:854217" /db_xref="SGD:S000005578" ORIGIN 1 msdineieip srkdeirqvt pkdpmheied kstyhakikk sdsgtvlgai plnsrsssns 61 svtstgqssr rvtkkttkkk kknacyfdtc ssaaskfigd cnfckghfcs khrlmenhac 121 ngltsckeql hqrnadklea eqtkapkiqi // LOCUS NP_014697 674 aa linear PLN 30-JUN-2025 DEFINITION phosphopantothenoylcysteine decarboxylase complex subunit VHS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014697 VERSION NP_014697.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183473.1 REFERENCE 1 (residues 1 to 674) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 674) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 674) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 674) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 674) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10834. Method: conceptual translation. FEATURES Location/Qualifiers source 1..674 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..674 /product="phosphopantothenoylcysteine decarboxylase complex subunit VHS3" /calculated_mol_wt="73518" Region <434..561 /region_name="Flavoprotein" /note="cl19190" /db_xref="CDD:450266" CDS 1..674 /gene="VHS3" /locus_tag="YOR054C" /gene_synonym="YOR29-05" /coded_by="NM_001183473.1:1..2025" /experiment="EXISTENCE:direct assay:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]" /experiment="EXISTENCE:direct assay:GO:0004864 protein phosphatase inhibitor activity [PMID:15192104]" /experiment="EXISTENCE:direct assay:GO:0071513 phosphopantothenoylcysteine decarboxylase complex [PMID:19915539]" /experiment="EXISTENCE:direct assay:GO:1990143 CoA-synthesizing protein complex [PMID:23789928]" /experiment="EXISTENCE:genetic interaction:GO:0015937 coenzyme A biosynthetic process [PMID:19915539]" /experiment="EXISTENCE:genetic interaction:GO:0030003 intracellular monoatomic cation homeostasis [PMID:15192104]" /experiment="EXISTENCE:mutant phenotype:GO:0004633 phosphopantothenoylcysteine decarboxylase activity [PMID:19915539]" /experiment="EXISTENCE:physical interaction:GO:0030003 intracellular monoatomic cation homeostasis [PMID:15192104]" /note="Negative regulatory subunit of protein phosphatase 1 Ppz1p; involved in coenzyme A biosynthesis; subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex and the CoA-Synthesizing Protein Complex (CoA-SPC: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p)" /db_xref="GeneID:854220" /db_xref="SGD:S000005580" ORIGIN 1 mtnksslknn rkgvasntls gaeqanigss ampdtnstgp fssvssldtp vvrkstsptg 61 sqtksimnas gtsgavvsnt pepglkript vtfsdpklgs lrsdveqtpp nqvarqssek 121 katsvhiaae ganqgrnlkd intkvpkdge asassfstpt silsnadmgn nissllakkl 181 sftggtdsil nsdnssdspr kehphfyved plhtpsvrsr snstsprpsv vvntfnpini 241 eregsisktg eptllesvle eamspnavsn plkrenimtn mdprlpqddg klhvlfgatg 301 slsvfklkhm irkleeiygr dkiciqvilt nsatkffamk ymrknkkqhn sidtsfnstn 361 snagnitgnk kkvaslekfs iqktssnsaa sqtnnkqeee kqmasttgfp stlggsrtys 421 nssnvvsqhp qielpahiqf wtdqdewdvw rqrtdpvlhi elrrwadilv vapltantla 481 kialglcdnl ltsvirawnp tfpiflapsm gsgtfnsimt kkhfriiqee mpwvtvfkps 541 ekvmgingdi glsgmmdane ivgkivvklg gypdvsagke eeededndee ddnkkndtgg 601 kdednddddd dddddddddd dddddddddd dddddddddd dddddddddd eddedededd 661 egkkkedkgg lqrs // LOCUS NP_014699 459 aa linear PLN 30-JUN-2025 DEFINITION rRNA-binding endoribonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_014699 VERSION NP_014699.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183475.1 REFERENCE 1 (residues 1 to 459) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 459) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 459) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 459) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 459) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10835. Method: conceptual translation. FEATURES Location/Qualifiers source 1..459 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..459 /product="rRNA-binding endoribonuclease" /calculated_mol_wt="51611" Region 12..102 /region_name="PIN_6" /note="PIN domain of ribonuclease; pfam17146" /db_xref="CDD:465362" Region 294..371 /region_name="NOB1_Zn_bind" /note="Nin one binding (NOB1) Zn-ribbon like; pfam08772" /db_xref="CDD:462597" CDS 1..459 /gene="NOB1" /locus_tag="YOR056C" /gene_synonym="YOR29-07" /coded_by="NM_001183475.1:1..1380" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:19801658]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12502737|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030490 maturation of SSU-rRNA [PMID:19801658]" /experiment="EXISTENCE:direct assay:GO:0030688 preribosome, small subunit precursor [PMID:12588997]" /experiment="EXISTENCE:direct assay:GO:0070181 small ribosomal subunit rRNA binding [PMID:19706509]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15388878|PMID:12588997]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:12502737]" /experiment="EXISTENCE:physical interaction:GO:0043248 proteasome assembly [PMID:12502737]" /note="Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress" /db_xref="GeneID:854221" /db_xref="SGD:S000005582" ORIGIN 1 mtenqtahvr alildatpli tqsythyqny aqsfyttptv fqeikdaqar knleiwqslg 61 tlklvhpsen siakvstfak ltgdysvlsa ndlhilalty eleiklnngd wrlrkkpgda 121 ldaskadvgt dgkqkltedn kkeedsesvp kkknkrrggk kqkakreare areaenanle 181 leskaeehve eagskeqicn denikessdl nevfedaddd gdwitpenlt eaiikdsged 241 ttgslgveas eedrhvalnr penqvalatg dfavqnvalq mnlnlmnfms glkikrirny 301 mlrchacfki fplpkdgkpk hfcascggqg tllrcavsvd srtgnvtphl ksnfqwnnrg 361 nrysvaspls knsqkrygkk ghvhskpqen vilredqkey ekvikqeewt rrhnekilnn 421 wigggsadny ispfaitglk qhnvrigkgr yvnsskrrs // LOCUS NP_014700 395 aa linear PLN 30-JUN-2025 DEFINITION co-chaperone SGT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014700 VERSION NP_014700.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183476.1 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10836. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..395 /product="co-chaperone SGT1" /calculated_mol_wt="44729" Region 10..395 /region_name="SGT1" /note="Suppressor of G2 allele of skp1 and related proteins [General function prediction only]; COG5091" /db_xref="CDD:227422" Region 37..77 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 82..114 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..395 /gene="SGT1" /locus_tag="YOR057W" /coded_by="NM_001183476.1:1..1188" /experiment="EXISTENCE:direct assay:GO:0000151 ubiquitin ligase complex [PMID:10445024]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:34192536]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:34192536]" /experiment="EXISTENCE:direct assay:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:34192536]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:16945921]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:34192536|PMID:16945921]" /experiment="EXISTENCE:direct assay:GO:0051382 kinetochore assembly [PMID:10445024]" /experiment="EXISTENCE:direct assay:GO:0065003 protein-containing complex assembly [PMID:15090617]" /note="Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854222" /db_xref="SGD:S000005583" ORIGIN 1 mpvekdlkta ykalydekep lkalhlydei lkgsptnlta lifkaaclek lyfgfsdwhs 61 datmenakel ldkalmtaeg rgdrskiglv nfryfvhffn ikdyelaqsy fkkaknlgyv 121 ddtlplwedr letklnkknk kqkdstnkht ikpvesienr gdnnsshspi splkietapq 181 espkfkidwy qsstsvtisl ftvnlpeske qvniyispnd rrtlsisyqv pksgsefqyn 241 aklshevdpk avslkifpkk leitlskids tqwkkleedi ltessrlsde gknsdsatrl 301 lsaetasker lsypssskkk idwskldide eadeeagsad sffqklyaga dpdtkrammk 361 sfiesngtal stdwedvskg tvktsppegm epkhw // LOCUS NP_116582 885 aa linear PLN 30-JUN-2025 DEFINITION Ase1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_116582 VERSION NP_116582.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183477.1 REFERENCE 1 (residues 1 to 885) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 885) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 885) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 885) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 885) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10837. Method: conceptual translation. FEATURES Location/Qualifiers source 1..885 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..885 /product="Ase1p" /calculated_mol_wt="101493" Region 102..682 /region_name="MAP65_ASE1" /note="Microtubule associated protein (MAP65/ASE1 family); pfam03999" /db_xref="CDD:427641" CDS 1..885 /gene="ASE1" /locus_tag="YOR058C" /gene_synonym="YOR29-09" /coded_by="NM_001183477.1:1..2658" /experiment="EXISTENCE:direct assay:GO:0001578 microtubule bundle formation [PMID:12591913]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005880 nuclear microtubule [PMID:7559759]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:12591913]" /experiment="EXISTENCE:direct assay:GO:0072686 mitotic spindle [PMID:7559759]" /experiment="EXISTENCE:direct assay:GO:1990023 mitotic spindle midzone [PMID:7559759]" /experiment="EXISTENCE:genetic interaction:GO:0000022 mitotic spindle elongation [PMID:7559759]" /experiment="EXISTENCE:genetic interaction:GO:0000073 initial mitotic spindle pole body separation [PMID:16688214]" /experiment="EXISTENCE:mutant phenotype:GO:0000022 mitotic spindle elongation [PMID:12591913|PMID:7559759]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:16615892]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:9036857]" /experiment="EXISTENCE:mutant phenotype:GO:0051255 spindle midzone assembly [PMID:17562791]" /note="Mitotic spindle midzone-localized microtubule bundling protein; microtubule-associated protein (MAP) family member; required for anaphase spindle elongation and stabilization; selectively increases the lifetime of antiparallel microtubule overlaps; undergoes cell cycle-regulated degradation by anaphase promoting complex; relative distribution to microtubules decreases upon DNA replication stress" /db_xref="GeneID:854223" /db_xref="SGD:S000005584" ORIGIN 1 metatssplp iksrrnsens gsttviphmn pslatpltvs tmvnqsnske fmkltpvrir 61 dfgsplknvs tnyhfldsen gkgntmdnmy renfiliskd lekllenlnv iyqnigysnt 121 eiitkekiif ttisnsikqf feqadeelkr lsaengieqd ilnnilerin dpsgiktipd 181 lyirnaillq esktvpqspk kplsllskka aldtakkfvl gsflprlrdy lkslitlkhl 241 iqsvkenlpg lteadneaia efpelstlta yllqiengkg diglsmkfii dnrkdilkgs 301 afktineesv khmnevikiy eeeyerrfks vltkkvsiss iceqlgtpla tligedfeqd 361 lrsygeeens tseipnfhpv drermskidi tleklqaihk eradkkrllm eqcqklwtrl 421 kisqeyiktf mrnnsslste slgriskevm rleamkkkli kklisdswdk iqelwrtlqy 481 seesrskfii vfeelrnsat tlqedellle tcenelkrle ekltlykpil klisdfeslq 541 edqeflerss kdssrllsrn shkillteek mrkritrhfp rvindlrikl eeadglfdqp 601 flfkgkplse aidiqqqeie akyprcrvrm qrskkgkcga nkenkviknt fkatessirv 661 piglnlndan ityktpskkt iqgltkndls qenslarhmq gttklsspnr ratrllaptv 721 isrnskgnie rptlnrnrss dlsssprinh thgehavkpr qlfpiplnkv dtkgshipql 781 tkekalellk rstgttgken vrsperkssl edyaqklssp ykepehsiyk lsmspegkfq 841 lniqqkdies gfddtsmmed endkdfitwk neqvsklngf sftdi // LOCUS NP_014702 450 aa linear PLN 30-JUN-2025 DEFINITION putative hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014702 VERSION NP_014702.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183478.1 REFERENCE 1 (residues 1 to 450) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 450) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 450) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 450) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10838. Method: conceptual translation. FEATURES Location/Qualifiers source 1..450 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..450 /product="putative hydrolase" /EC_number="3.1.1.4" /calculated_mol_wt="50975" Region 5..209 /region_name="DUF676" /note="Putative serine esterase (DUF676); pfam05057" /db_xref="CDD:309968" CDS 1..450 /gene="LPL1" /locus_tag="YOR059C" /gene_synonym="YOR29-10" /coded_by="NM_001183478.1:1..1353" /experiment="EXISTENCE:direct assay:GO:0004622 phosphatidylcholine lysophospholipase activity [PMID:25014274]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:25014274|PMID:24868093|PMID:10515935]" /experiment="EXISTENCE:mutant phenotype:GO:0004622 phosphatidylcholine lysophospholipase activity [PMID:25014274]" /experiment="EXISTENCE:mutant phenotype:GO:0055088 lipid homeostasis [PMID:25014274]" /note="Phospholipase; contains lipase specific GXSXG motif; maintains lipid droplet (LD) morphology; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854225" /db_xref="SGD:S000005585" ORIGIN 1 mtsdkhlfvl ihglwgnyth mesmrtilst tlkkedvndd miyflpkqna mfktfdgiei 61 igyrtlievc efirdykdgk itklsvmgys qgglvarfmi gkmltefkel fediepqlfi 121 tmatphlgve fynptgiayk salysalrtl gstilgksgr emfianssnn ilvklsqgey 181 lealslfkwr iafanvkndr tvafytafit dcdpfidfdn klkytfeeki pgsgykgilp 241 kivdlnalnv nshaptkptk tykkwgrtil iilvatflil pialvmnglg taysyivtck 301 yrkmlsngil hnevrgklgl teqlkgyvtd aygsiinsal dmdanyeasn snlvneeelp 361 wkefiqkytt indgvwkskf kklpfdenrk vilrnlnklk wirvpiyika vnahgvivar 421 rgmdentaat giacieftaq llaylmhksn // LOCUS NP_014703 257 aa linear PLN 30-JUN-2025 DEFINITION Sld7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014703 VERSION NP_014703.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183479.1 REFERENCE 1 (residues 1 to 257) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 257) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 257) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 257) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 257) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10839. Method: conceptual translation. FEATURES Location/Qualifiers source 1..257 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..257 /product="Sld7p" /calculated_mol_wt="29426" Region 3..125 /region_name="Sld7_N" /note="Mitochondrial morphogenesis protein SLD7 N-terminal domain; pfam18636" /db_xref="CDD:436638" Region 181..255 /region_name="Sld7_C" /note="Sld7 C-terminal domain; pfam18596" /db_xref="CDD:436607" CDS 1..257 /gene="SLD7" /locus_tag="YOR060C" /gene_synonym="YOR29-11" /coded_by="NM_001183479.1:1..774" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23746350]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:14562095|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:21487389]" /experiment="EXISTENCE:genetic interaction:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:21487389]" /experiment="EXISTENCE:physical interaction:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:21487389]" /note="Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria; ortholog of human MTBP, which is a DNA replication origin firing factor" /db_xref="GeneID:854226" /db_xref="SGD:S000005586" ORIGIN 1 msrklctlnf tlsgkqgslv irdiqlwsnr ptaskstsel rgqfiqyvdl aklplwvrst 61 nmntyrcyst sataqayfks klrnanrgiv ielfdkvdqr sqepayliif rentelncfq 121 vdltmkhefd gqvtklkqdi gktrasvske gsidiiiqqs qqrkigtkte vyrnvhindk 181 rlqfnetlsk lilgglrlrg isnsitdyqk lykitfdaae fthrdelkri smgsgeevsf 241 eslqetvetl lklftks // LOCUS NP_014704 339 aa linear PLN 30-JUN-2025 DEFINITION casein kinase 2 catalytic subunit CKA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014704 VERSION NP_014704.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183480.1 REFERENCE 1 (residues 1 to 339) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 339) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 339) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 339) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10840. Method: conceptual translation. FEATURES Location/Qualifiers source 1..339 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..339 /product="casein kinase 2 catalytic subunit CKA2" /EC_number="2.7.11.1" /calculated_mol_wt="39273" Region 30..335 /region_name="STKc_CK2_alpha" /note="Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; cd14132" /db_xref="CDD:271034" Site order(47,50..52,78,80,112,114..115,121) /site_type="other" /note="allosteric inhibitor binding site [chemical binding]" /db_xref="CDD:271034" Site order(47..48,50..53,61,65,114) /site_type="other" /note="tetramer interface [polypeptide binding]" /db_xref="CDD:271034" Site order(47..48,50..52,68,70,114) /site_type="other" /note="CK2 beta interface [polypeptide binding]" /db_xref="CDD:271034" Site order(56..60,64,77,79,91,106,124..127,131,133..134,167,169, 171..172,174,186,189,200,202..205,207,246) /site_type="active" /db_xref="CDD:271034" Site order(58..59,61..62,64,77,79,106,124..125,127,171..172,174, 185..186) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271034" Site order(91,133,167,169,189,200,202..205,207,246) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271034" Site order(185..195,200..207) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271034" CDS 1..339 /gene="CKA2" /locus_tag="YOR061W" /gene_synonym="YOR29-12" /coded_by="NM_001183480.1:1..1020" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8226802]" /experiment="EXISTENCE:direct assay:GO:0005956 protein kinase CK2 complex [PMID:8135547]" /experiment="EXISTENCE:direct assay:GO:0006356 regulation of transcription by RNA polymerase I [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0006359 regulation of transcription by RNA polymerase III [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0006974 DNA damage response [PMID:11551505]" /experiment="EXISTENCE:direct assay:GO:0034456 UTP-C complex [PMID:17515605]" /experiment="EXISTENCE:genetic interaction:GO:0007535 donor selection [PMID:22496671]" /note="Alpha' catalytic subunit of casein kinase 2 (CK2); CK2 is a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases; protein abundance increases in response to DNA replication stress; regulates Fkh1p-mediated donor preference during mating-type switching" /db_xref="GeneID:854227" /db_xref="SGD:S000005587" ORIGIN 1 mplppstlnq ksnrvysvar vyknaceerp qeywdyeqgv tidwgkisny eiinkigrgk 61 ysevfsgrci vnnqkcvikv lkpvkmkkiy relkiltnlt ggpnvvglyd ivqdadskip 121 alifeeiknv dfrtlyptfk lpdiqyyftq llialdychs mgimhrdvkp qnvmidpter 181 klrlidwgla efyhpgvdyn vrvasryhkg pellvnlnqy dysldlwsvg cmlaaivfkk 241 epffkgssnp dqlvkiatvl gtkellgylg kyglhlpsey dnimrdftkk swthfitset 301 klavpevvdl idnllrydhq erltakeamd hkffktkfe // LOCUS NP_014705 268 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR062C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014705 VERSION NP_014705.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183481.1 REFERENCE 1 (residues 1 to 268) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 268) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 268) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 268) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10841. Method: conceptual translation. FEATURES Location/Qualifiers source 1..268 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..268 /product="uncharacterized protein" /calculated_mol_wt="31749" CDS 1..268 /locus_tag="YOR062C" /gene_synonym="YOR29-13" /coded_by="NM_001183481.1:1..807" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; similar to Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; YOR062C has a paralog, YKR075C, that arose from the whole genome duplication" /db_xref="GeneID:854228" /db_xref="SGD:S000005588" ORIGIN 1 mtslddsvlt kknialldna tnyirpaidy fhfkfnydsl dvsttwrlll kmrkhkllrl 61 pscssenefd ysiymarlyh ciwrrwsikh fnldeykidp lsinwnkeid vtvlygpdlv 121 gihereqptp tdfpmgnike qgkqlldvrk egsassllkk gsvfyskgkw lsqrsisfdd 181 tvrrrdidkr grfrescvli ndveqfqnys ivwdesrhry rrqalpdtyd yehlypngde 241 tprntphdni iihqnlhsit egsyiyik // LOCUS NP_014706 387 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL3 RPL3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014706 VERSION NP_014706.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183482.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10842. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..387 /product="60S ribosomal protein uL3 RPL3" /calculated_mol_wt="43627" Region 1..387 /region_name="PTZ00103" /note="60S ribosomal protein L3; Provisional" /db_xref="CDD:240267" CDS 1..387 /gene="RPL3" /locus_tag="YOR063W" /gene_synonym="MAK8; TCM1; YOR29-14" /coded_by="NM_001183482.1:1..1164" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:3537704]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:26826131]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:26826131]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:9858562|PMID:26826131]" /note="Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; plays an important role in function of eIF5B in stimulating 3' end processing of 18S rRNA in context of 80S ribosomes that have not yet engaged in translation; involved in replication and maintenance of killer double stranded RNA virus" /db_xref="GeneID:854229" /db_xref="SGD:S000005589" ORIGIN 1 mshrkyeapr hghlgflprk raasirarvk afpkddrskp valtsflgyk agmttivrdl 61 drpgskfhkr evveavtvvd tppvvvvgvv gyvetprglr slttvwaehl sdevkrrfyk 121 nwykskkkaf tkysakyaqd gagierelar ikkyasvvrv lvhtqirktp laqkkahlae 181 iqlnggsise kvdwarehfe ktvavdsvfe qnemidaiav tkghgfegvt hrwgtkklpr 241 kthrglrkva cigawhpahv mwsvaragqr gyhsrtsinh kiyrvgkgdd eangatsfdr 301 tkktitpmgg fvhygeiknd fimvkgcipg nrkrivtlrk slytntsrka leevslkwid 361 taskfgkgrf qtpaekhafm gtlkkdl // LOCUS NP_014707 219 aa linear PLN 30-JUN-2025 DEFINITION Yng1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014707 VERSION NP_014707.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183483.1 REFERENCE 1 (residues 1 to 219) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 219) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 219) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 219) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 219) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10843. Method: conceptual translation. FEATURES Location/Qualifiers source 1..219 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..219 /product="Yng1p" /calculated_mol_wt="25219" Region 1..206 /region_name="TNG2" /note="Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]; COG5034" /db_xref="CDD:227367" CDS 1..219 /gene="YNG1" /locus_tag="YOR064C" /gene_synonym="YOR29-15" /coded_by="NM_001183483.1:1..660" /experiment="EXISTENCE:direct assay:GO:0033100 NuA3 histone acetyltransferase complex [PMID:17157260]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:17157260|PMID:16923967]" /experiment="EXISTENCE:direct assay:GO:1990467 NuA3a histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:25104842]" /experiment="EXISTENCE:mutant phenotype:GO:0004402 histone acetyltransferase activity [PMID:12077334]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:10805724]" /experiment="EXISTENCE:mutant phenotype:GO:0140002 histone H3K4me3 reader activity [PMID:17157260]" /experiment="EXISTENCE:physical interaction:GO:0033100 NuA3 histone acetyltransferase complex [PMID:12077334]" /note="Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3; shares significant sequence identity with the human candidate tumor suppressor p33-ING1 in C-terminal region" /db_xref="GeneID:854230" /db_xref="SGD:S000005590" ORIGIN 1 mehlanensd sdirysflst ldhlpcelir slrlmqtidl fkneedepgm eracrdlllv 61 atyindlvdd qihflkqhkk eleiqksvtk nfnsslenik skltleepga ykepklllki 121 nlkkaksrer kesitsptig inqgdvtegn nnqeevycfc rnvsygpmva cdnpacpfew 181 fhygcvglkq apkgkwycsk dckeianqrs kskrqkrrk // LOCUS NP_014708 309 aa linear PLN 30-JUN-2025 DEFINITION ubiquinol--cytochrome-c reductase catalytic subunit CYT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014708 VERSION NP_014708.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183484.1 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10844. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..309 /product="ubiquinol--cytochrome-c reductase catalytic subunit CYT1" /EC_number="7.1.1.8" /calculated_mol_wt="33924" Region <39..>109 /region_name="CccA" /note="Cytochrome c, mono- and diheme variants [Energy production and conversion]; COG2010" /db_xref="CDD:441613" Region 76..295 /region_name="Cytochrom_C1" /note="Cytochrome C1 family; pfam02167" /db_xref="CDD:426633" CDS 1..309 /gene="CYT1" /locus_tag="YOR065W" /gene_synonym="CTC1; YOR29-16" /coded_by="NM_001183484.1:1..930" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:10873857]" /experiment="EXISTENCE:mutant phenotype:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:11279090]" /experiment="EXISTENCE:mutant phenotype:GO:0008121 quinol-cytochrome-c reductase activity [PMID:11279090]" /note="Cytochrome c1; component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex" /db_xref="GeneID:854231" /db_xref="SGD:S000005591" ORIGIN 1 mfsnlskrwa qrtlsksfys tatgaasksg kltqklvtag vaaagitast llyadsltae 61 amtaaehglh apayawshng pfetfdhasi rrgyqvyrev caachsldrv awrtlvgvsh 121 tneevrnmae efeyddepde qgnpkkrpgk lsdyipgpyp neqaaraanq galppdlsli 181 vkarhggcdy ifslltgypd eppagvalpp gsnynpyfpg gsiamarvlf ddmveyedgt 241 pattsqmakd vttflnwcae pehderkrlg lktviilssl yllsiwvkkf kwagiktrkf 301 vfnppkprk // LOCUS NP_014709 629 aa linear PLN 30-JUN-2025 DEFINITION Msa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014709 VERSION NP_014709.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183485.1 REFERENCE 1 (residues 1 to 629) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 629) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 629) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 629) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 629) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10845. Method: conceptual translation. FEATURES Location/Qualifiers source 1..629 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..629 /product="Msa1p" /calculated_mol_wt="68560" CDS 1..629 /gene="MSA1" /locus_tag="YOR066W" /gene_synonym="YOR29-17" /coded_by="NM_001183485.1:1..1890" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19520826]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19520826]" /experiment="EXISTENCE:genetic interaction:GO:0007089 traversing start control point of mitotic cell cycle [PMID:18160399]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:18160399]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:18160399]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:18160399]" /experiment="EXISTENCE:physical interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:18160399]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:18160399]" /note="Activator of G1-specific transcription factors MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; MSA1 has a paralog, MSA2, that arose from the whole genome duplication" /db_xref="GeneID:854232" /db_xref="SGD:S000005592" ORIGIN 1 mdksmikkrg rppitkdypn plqspmahss mqvqkqgphs fakplmkvgq sspspnkrrl 61 sidhhhnlaa ttrkgryrgv llstptkkss tngstpistp ssndsynntv fsetrktflq 121 ssppimtssp afqkkndymf psqeqfklsl titesgkavi agslpfspss ksshlmnnnn 181 kkimqnekih kgskknapkf ekrrilsllk qmknekycdt dtlpeappak psrsdiidte 241 lptiietsas pigsarnnni llsqppqspp ssaqlkppst pksslqfrmg ftpnvalnsv 301 slsdtiskst navgasnnnn qngnsisnia dantlltltn spgvflsprn kmlpksttas 361 neqqqefvfk fssgdplllt ddadgnwpem lfnvsntprr qkcfntppsw infgspglfs 421 pprssnvmvn gttvatasds gnvhrqlqaq leaqvqvqsq snsptqrqqq qrqfqippph 481 inmnssppqi niaspphqsm srvssiyfnk ektttgvanm lgntksenlq ppanlftaah 541 gpstprnqef qlptliectp liqqtmngsl gtkyipgtsi snsatpnlhg fpvgtgkaps 601 sfddslkqnp ysnkqddart alkrliddq // LOCUS NP_014710 577 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014710 VERSION NP_014710.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183486.1 REFERENCE 1 (residues 1 to 577) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 577) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 577) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 577) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 577) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10846. Method: conceptual translation. FEATURES Location/Qualifiers source 1..577 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..577 /product="dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase" /EC_number="2.4.1.265" /calculated_mol_wt="67254" Region 52..565 /region_name="Alg6_Alg8" /note="ALG6, ALG8 glycosyltransferase family; pfam03155" /db_xref="CDD:460831" CDS 1..577 /gene="ALG8" /locus_tag="YOR067C" /gene_synonym="YOR29-18" /coded_by="NM_001183486.1:1..1734" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006487 protein N-linked glycosylation [PMID:8016100]" /experiment="EXISTENCE:mutant phenotype:GO:0005789 endoplasmic reticulum membrane [PMID:8016100]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:3536907]" /experiment="EXISTENCE:mutant phenotype:GO:0042283 dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity [PMID:3536907]" /note="Glucosyl transferase; involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p; human homolog ALG8 can complement yeast null mutant" /db_xref="GeneID:854233" /db_xref="SGD:S000005593" ORIGIN 1 mkgdrsrqnm avtkkaklkk ndepkkvlkt aatekgegsk ryslwnfwis tlflklllip 61 dyfstdfdvh rnwlaitnkl pisewyyeht sqwtldyppf fayfewflsq fvpksvrddg 121 cldiveigkf glptivfqrl tvifseillf vilqiyintt klsersqsfv vassivlspg 181 fliidhihfq yngflfaili gsivaaknkr yilcavlytt aicfkhifly lapcyfvfll 241 rayvlnvnnf kfksykdflf lirwanllkl atvvvgifti cflpfahqmp qvlsrlfpfs 301 rglthaywap nfwalysfmd kilttvmlkl pyvhtfatkf ikpplipqni keinerlaan 361 nngskglvqd vffvilpqip pkltfiltif yqvlavlpll fdpsfkrfvg sltlcglasf 421 lfgwhvheka imlviipftf lvgfdrrllv pfmlvasagy vslypllykg qdffiktlyt 481 yvwciiyfaa frkttkisss verriffldr laltyifsll pivtvlqild evkwrysflq 541 kfeflglmiy svycslgiis swfalswlyn fdellwq // LOCUS NP_014712 675 aa linear PLN 30-JUN-2025 DEFINITION sorting nexin 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014712 VERSION NP_014712.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183488.1 REFERENCE 1 (residues 1 to 675) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 675) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 675) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 675) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10847. On Apr 26, 2004 this sequence version replaced NP_014712.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..675 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..675 /product="sorting nexin 1" /calculated_mol_wt="76353" Region 281..390 /region_name="PX_Vps5p" /note="The phosphoinositide binding Phox Homology domain of yeast sorting nexin Vps5p; cd06861" /db_xref="CDD:132771" Site order(320..322,346..347,360) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:132771" Region 460..673 /region_name="BAR_Vps5p" /note="The Bin/Amphiphysin/Rvs (BAR) domain of yeast Sorting Nexin Vps5p; cd07627" /db_xref="CDD:153311" Site order(471,474..475,478..479,481..482,485,488..489,492, 499..500,502..503,506,509..510,513..514,530,635,638..639, 641..643,646,649..650,652..654,656..657,660..661,663..664, 667..668,670..671) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153311" CDS 1..675 /gene="VPS5" /locus_tag="YOR069W" /gene_synonym="GRD2; PEP10; VPT5" /coded_by="NM_001183488.1:1..2028" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:9175702|PMID:9700157]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9175702]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:mutant phenotype:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0140312 cargo adaptor activity [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0030905 retromer, tubulation complex [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0140312 cargo adaptor activity [PMID:9700157]" /note="Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes; VPS5 has a paralog, YKR078W, that arose from the whole genome duplication" /db_xref="GeneID:854235" /db_xref="SGD:S000005595" ORIGIN 1 mdyednleap vwdelnhegd ktqslvsnsi esigqistne erkdnellet tasfadkidl 61 dsapewkdpg lsvagnpqle ehdnskaddl inslapeqdp iadlknsttq fiatresgga 121 lftgnanspl vfddtiydan tspntsksis grrsgkpril fdsaraqrns krnhslkakr 181 ttasddtikt pftdplkkae kenefveepl ddrnerrenn egkftasvek nileqvdrpl 241 ynlpqtgani sspaeveens ekfgktkigs kvpptekava fkvevkdpvk vgeltsihve 301 ytvisessll elkyaqvsrr yrdfrwlyrq lqnnhwgkvi ppppekqsvg sfkenfienr 361 rfqmesmlkk icqdpvlqkd kdfllfltsd dfsseskkra fltgsgaind sndlsevris 421 eiqllgaeda aevlknggid aeshkgfmsi sfsslpkyne adeffiekkq kidelednlk 481 klskslemvd tsrntlaast eefssmvetl aslnvsepns ellnnfadvh ksiksslers 541 slqetltmgv mlddyirsla svkaifnqrs klgyflvvie ndmnkkhsql gklgqnihse 601 kfremrkefq tlerrynltk kqwqavgdki kdefqgfstd kirefrngme isleaaiesq 661 kecielwetf yqtnl // LOCUS NP_014711 114 aa linear PLN 30-JUN-2025 DEFINITION Vam10p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014711 VERSION NP_014711.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183487.1 REFERENCE 1 (residues 1 to 114) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 114) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 114) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 114) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 114) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10848. Method: conceptual translation. FEATURES Location/Qualifiers source 1..114 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..114 /product="Vam10p" /calculated_mol_wt="11632" CDS 1..114 /gene="VAM10" /locus_tag="YOR068C" /coded_by="NM_001183487.1:1..345" /experiment="EXISTENCE:curator inference:GO:0000329 fungal-type vacuole membrane [PMID:12748377]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:12748377]" /note="Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering" /db_xref="GeneID:854234" /db_xref="SGD:S000005594" ORIGIN 1 mlfevfgevl asyivssktk gelafpvnna ppdslvainc vvlflrsaig scsgakelir 61 ssalelscss scglpatdkp gsfhsgalsk silsaneavv sksslsflss fvdi // LOCUS NP_014713 637 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein GYP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014713 VERSION NP_014713.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183489.1 REFERENCE 1 (residues 1 to 637) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 637) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 637) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 637) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 637) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10849. Method: conceptual translation. FEATURES Location/Qualifiers source 1..637 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..637 /product="GTPase-activating protein GYP1" /calculated_mol_wt="73158" Region 24..632 /region_name="COG5210" /note="GTPase-activating protein [General function prediction only]" /db_xref="CDD:227535" CDS 1..637 /gene="GYP1" /locus_tag="YOR070C" /gene_synonym="YOR29-21" /coded_by="NM_001183489.1:1..1914" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:10508155]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:35134079]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:11359917]" /experiment="EXISTENCE:direct assay:GO:0016192 vesicle-mediated transport [PMID:11118206]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:10508155]" /note="Cis-golgi GTPase-activating protein (GAP) for yeast Rabs; the Rab family members are Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion; interacts with autophagosome component Atg8p" /db_xref="GeneID:854236" /db_xref="SGD:S000005596" ORIGIN 1 mgvrsaakem herdhnsdss slvtslmksw rissassskk pslykmntte stslpsgyas 61 sadrdrrtsd gnfeamakqq astrrtsnsy splryvnptl stasnesprp alllrqhhqr 121 hhhhqqprhs ssgsvgnncs nstepnkkgd ryfkdldedw saviddynmp ipiltnggfg 181 tpvaptrtls rkstsssins isnmgtsavr nssssftypq lpqlqkektn dskktqleie 241 nerdvqelns iiqriskfdn ilkdktiinq qdlrqiswng ipkihrpvvw klligylpvn 301 tkrqegflqr krkeyrdslk htfsdqhsrd iptwhqieid iprtnphipl yqfksvqnsl 361 qrilylwair hpasgyvqgi ndlvtpffet flteylppsq iddveikdps tymvdeqitd 421 leadtfwclt klleqitdny ihgqpgilrq vknlsqlvkr idadlynhfq nehvefiqfa 481 frwmncllmr efqmgtvirm wdtylsetsq evtssysmss ndikppvtpt eprvasfvtp 541 tkdfqsptta lsnmtpnnav edsgkmrqss lnefhvfvca aflikwsdql memdfqetit 601 flqnpptkdw tetdiemlls eafiwqslyk datshwl // LOCUS NP_014714 598 aa linear PLN 30-JUN-2025 DEFINITION nicotinamide riboside transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_014714 VERSION NP_014714.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183490.1 REFERENCE 1 (residues 1 to 598) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 598) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 598) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 598) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 598) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10850. Method: conceptual translation. FEATURES Location/Qualifiers source 1..598 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..598 /product="nicotinamide riboside transporter" /calculated_mol_wt="67063" Region 27..505 /region_name="SLC-NCS1sbd_NRT1-like" /note="nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain; cd11482" /db_xref="CDD:271375" Site order(53,56,342,345..346) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271375" Site order(57,133,137,254..255,257,347,351) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:271375" CDS 1..598 /gene="NRT1" /locus_tag="YOR071C" /gene_synonym="THI71; YOR29-22" /coded_by="NM_001183490.1:1..1797" /experiment="EXISTENCE:genetic interaction:GO:0015888 thiamine transport [PMID:9235906|PMID:16850348]" /experiment="EXISTENCE:genetic interaction:GO:0034257 nicotinamide riboside transmembrane transporter activity [PMID:18258590]" /experiment="EXISTENCE:genetic interaction:GO:0034258 nicotinamide riboside transport [PMID:18258590]" /experiment="EXISTENCE:mutant phenotype:GO:0034257 nicotinamide riboside transmembrane transporter activity [PMID:18258590]" /experiment="EXISTENCE:mutant phenotype:GO:0034258 nicotinamide riboside transport [PMID:18258590]" /experiment="EXISTENCE:mutant phenotype:GO:1903088 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport [PMID:24778186]" /experiment="EXISTENCE:mutant phenotype:GO:1903089 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity [PMID:24778186]" /note="High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; major transporter for 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine) uptake; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity" /db_xref="GeneID:854237" /db_xref="SGD:S000005597" ORIGIN 1 msfssivskf lryleipakn rtavnflrnp dlqpiksanq twgfwsnlay wgavsftagt 61 wmsgsaalsv glsypetivs fllgnvltii ftmansypgy dwkigftlaq rfvfgiygsa 121 fgiiirilms ivnygsnawl gglsinmild swshhylhlp ntlspsvamt tkqlvgfiif 181 hvltalcyfm kpyhmnylli wscvatcfam lgiviyltkn ahgvgelfts tkstvtgskr 241 awawvymisy wfgsispgst nqsdysrfgs snlaiwtgsv callipatlv pifgvisast 301 cdklygkqfw mpmdifdywl tnnysagara gaffcglcft msqmsstisn cgfatgmdma 361 gllpkyvdik rgalfcacis waclpwnfyn ssstfltvms sfgvvmtpii avmicdnfli 421 rkrqysitna filkgeyyft kgvnwraiva wvcgmapglp giawevnnny fhdsgivkff 481 ygdsffsfli sffvywglcv ffpfkitvrh ddkdyygaft deearkkgmi pyseiseeei 541 raytlgecyt tgheykpess dnespelikt ssentnvfei vhqkddekhs fsttqqvv // LOCUS NP_001335816 104 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR072W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335816 VERSION NP_001335816.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348878.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80336. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..104 /product="uncharacterized protein" /calculated_mol_wt="12009" CDS 1..104 /locus_tag="YOR072W" /gene_synonym="YOR29-23" /coded_by="NM_001348878.1:1..315" /note="hypothetical protein; conserved across S. cerevisiae strains; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive" /db_xref="GeneID:854238" /db_xref="SGD:S000005598" ORIGIN 1 mltkvvflff wsrsdstkkl aacnhatlah yiltpalysd acaiysdvys itiivvatvv 61 rnparcslra rkfcrlfssf fqfhylkelf yfirkpddkf ssfi // LOCUS NP_878171 53 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR072W-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_878171 VERSION NP_878171.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184526.1 REFERENCE 1 (residues 1 to 53) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 53) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 53) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 53) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 53) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10851. Method: conceptual translation. FEATURES Location/Qualifiers source 1..53 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..53 /product="uncharacterized protein" /calculated_mol_wt="6002" CDS 1..53 /locus_tag="YOR072W-B" /coded_by="NM_001184526.1:1..162" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466483" /db_xref="SGD:S000028516" ORIGIN 1 milalgdflt nrktkhargp gfnsqlapfi fdylfpigrv tdffyffqgp fvl // LOCUS NP_014716 590 aa linear PLN 30-JUN-2025 DEFINITION Sgo1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014716 VERSION NP_014716.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183492.1 REFERENCE 1 (residues 1 to 590) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 590) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 590) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 590) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 590) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10852. Method: conceptual translation. FEATURES Location/Qualifiers source 1..590 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..590 /product="Sgo1p" /calculated_mol_wt="66575" Region 43..87 /region_name="Shugoshin_N" /note="Shugoshin N-terminal coiled-coil region; pfam07558" /db_xref="CDD:462208" Region 366..389 /region_name="Shugoshin_C" /note="Shugoshin C terminus; pfam07557" /db_xref="CDD:462207" CDS 1..590 /gene="SGO1" /locus_tag="YOR073W" /gene_synonym="YOR29-24" /coded_by="NM_001183492.1:1..1773" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:25236599]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:15062096|PMID:14730319]" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:28980861|PMID:16357219|PMID:14730319]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0045184 establishment of protein localization [PMID:25236599]" /experiment="EXISTENCE:direct assay:GO:0051383 kinetochore organization [PMID:22365852]" /experiment="EXISTENCE:genetic interaction:GO:0000070 mitotic sister chromatid segregation [PMID:15637284]" /experiment="EXISTENCE:genetic interaction:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:15637284]" /experiment="EXISTENCE:genetic interaction:GO:0034096 positive regulation of maintenance of meiotic sister chromatid cohesion [PMID:15062096]" /experiment="EXISTENCE:mutant phenotype:GO:0000070 mitotic sister chromatid segregation [PMID:15637284|PMID:14730319|PMID:15062096]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:24945276]" /experiment="EXISTENCE:mutant phenotype:GO:0000779 condensed chromosome, centromeric region [PMID:28980861]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:15637284]" /experiment="EXISTENCE:mutant phenotype:GO:0031134 sister chromatid biorientation [PMID:17980598|PMID:18081426|PMID:25236599]" /experiment="EXISTENCE:mutant phenotype:GO:0034090 maintenance of meiotic sister chromatid cohesion [PMID:14752166]" /experiment="EXISTENCE:mutant phenotype:GO:0034096 positive regulation of maintenance of meiotic sister chromatid cohesion [PMID:15062096]" /experiment="EXISTENCE:mutant phenotype:GO:0034508 centromere complex assembly [PMID:22365852]" /experiment="EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:14730319|PMID:15062096]" /experiment="EXISTENCE:mutant phenotype:GO:0045184 establishment of protein localization [PMID:25236599]" /experiment="EXISTENCE:mutant phenotype:GO:0051383 kinetochore organization [PMID:22365852]" /experiment="EXISTENCE:mutant phenotype:GO:0051757 meiotic sister chromatid separation [PMID:15062096]" /experiment="EXISTENCE:mutant phenotype:GO:0070199 establishment of protein localization to chromosome [PMID:24945276]" /note="Component of the spindle checkpoint; involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; recruits condensin to the pericentric region of chromosomes during meiosis; dissociates from pericentromeres when sister kinetochores are under tension" /db_xref="GeneID:854240" /db_xref="SGD:S000005599" ORIGIN 1 mpkrkiapnk essrrtvshd dltpqiqefq nlmdlesqkv enirqsysrq nsllakdnsi 61 lkikvnslek kisqlvqenv tlrsktsise aiyrerlsnq lqviengiiq rfdeifymfe 121 nvrknenlps sslrtmlkrt ssrsrscsls sptysksytr lsnhennlsh essfnkddgp 181 dlepkakkrk ssrrqsmfvs tslepedetg enepmmenss vevpaeshes aqveetidal 241 npeeensdsv snftnsiiey sipeenptep ehssskleif ndstnmlstv psnplplplp 301 gpsatlpttt sdastvypss ssstnshpkt kikhsmkppr ielkkkvide vmpvsnmssn 361 seisftrtrr trgkavdytl pslrakmrrp seklvdattv idihdlqvsk rnretshkrk 421 slsqdsipde pqlrevvvsk dygtpkgkkt edeihedtah lmttsnnnsn nknekkltsn 481 nspkksspll ditnksenkk kstrtkklfk naivnnlsde nsttrpskss kgtsnnnnny 541 nnfdnnnsni nnvnnksvsf rlneddlavf dlfgngkavk hqpktyrtkk // LOCUS NP_014717 304 aa linear PLN 30-JUN-2025 DEFINITION thymidylate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014717 VERSION NP_014717.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183493.1 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10853. On Dec 12, 2005 this sequence version replaced NP_014717.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..304 /product="thymidylate synthase" /EC_number="2.1.1.45" /calculated_mol_wt="34916" Region <5..304 /region_name="PTZ00164" /note="bifunctional dihydrofolate reductase-thymidylate synthase; Provisional" /db_xref="CDD:240299" CDS 1..304 /gene="CDC21" /locus_tag="YOR074C" /gene_synonym="CRT9; TMP1" /coded_by="NM_001183493.1:1..915" /experiment="EXISTENCE:direct assay:GO:0004799 thymidylate synthase activity [PMID:6287238]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:8132557]" /experiment="EXISTENCE:mutant phenotype:GO:0004799 thymidylate synthase activity [PMID:334734]" /experiment="EXISTENCE:mutant phenotype:GO:0006231 dTMP biosynthetic process [PMID:334734|PMID:794696]" /note="Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; human homolog TYMSOS can complement yeast cdc21 temperature-sensitive mutant at restrictive temperature" /db_xref="GeneID:854241" /db_xref="SGD:S000005600" ORIGIN 1 mtmdgknkee eqyldlckri idegefrpdr tgtgtlslfa ppqlrfslrd dtfpllttkk 61 vftrgiilel lwflagdtda nllseqgvki wdgngsreyl dkmgfkdrkv gdlgpvygfq 121 wrhfgakykt cdddytgqgi dqlkqvihkl ktnpydrrii msawnpadfd kmalppchif 181 sqfyvsfpke gegsgkprls cllyqrscdm glgvpfnias yalltrmiak vvdmepgefi 241 htlgdahvyk dhidalkeqi trnprpfpkl kikrdvkdid dfkltdfeie dynphpriqm 301 kmsv // LOCUS NP_014718 346 aa linear PLN 30-JUN-2025 DEFINITION Ufe1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014718 VERSION NP_014718.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183494.1 REFERENCE 1 (residues 1 to 346) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 346) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 346) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 346) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10854. Method: conceptual translation. FEATURES Location/Qualifiers source 1..346 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..346 /product="Ufe1p" /calculated_mol_wt="40408" Region 3..90 /region_name="Syntaxin-18_N" /note="SNARE-complex protein Syntaxin-18 N-terminus; pfam10496" /db_xref="CDD:463116" Region <170..341 /region_name="COG5325" /note="t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]" /db_xref="CDD:227635" Region 258..316 /region_name="SNARE_syntaxin18" /note="SNARE motif, subgroup Qa; cd15850" /db_xref="CDD:277203" Site order(259,261..262,264..269,271..273,275..276,278..280, 282..283,285..287,289..290,292..297,299..304,306..311, 313..315) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:277203" Site 289 /site_type="other" /note="zero layer" /db_xref="CDD:277203" CDS 1..346 /gene="UFE1" /locus_tag="YOR075W" /coded_by="NM_001183494.1:1..1041" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:8612273|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9214619]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8612273]" /experiment="EXISTENCE:mutant phenotype:GO:0016320 endoplasmic reticulum membrane fusion [PMID:9506516]" /note="t-SNARE protein required for retrograde vesicular traffic; involved in Sey1p-independent homotypic ER fusion; required for efficient nuclear fusion during mating; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER" /db_xref="GeneID:854242" /db_xref="SGD:S000005601" ORIGIN 1 mmsdltpifr kyvaviddar neqngiddhv erkqedfgns netcemfrds fikecarllk 61 flvelnkvik qieknylddf nmsdaekdef dmecrlqiqq yfkkfeflen yemerhnlsl 121 krfqskshrw skilsnkndn tkhvihpqdi engvyefrlg vlrclnlwik yvsskfttiq 181 qerlilenkm nfnstpmptl snnaddfsad aidisvsqsa pvetvqdevk hyeetisklt 241 qeqlqvlete hsellnqkne qlkkvetink tildivniqn elsnhltvqs qninlmlnnq 301 ddielnikkg nkelrkakra agrtakmtty gaiimgvfil fldyvg // LOCUS NP_014719 747 aa linear PLN 30-JUN-2025 DEFINITION Ski7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014719 VERSION NP_014719.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183495.1 REFERENCE 1 (residues 1 to 747) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 747) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 747) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 747) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10855. Method: conceptual translation. FEATURES Location/Qualifiers source 1..747 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..747 /product="Ski7p" /calculated_mol_wt="84648" Region 268..474 /region_name="GTP_EFTU" /note="Elongation factor Tu GTP binding domain; pfam00009" /db_xref="CDD:425418" Site 274..281 /site_type="other" /note="G1 box" /db_xref="CDD:206670" Site order(276..282,359,427..428,430,467..469) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206670" Site 356..359 /site_type="other" /note="G3 box" /db_xref="CDD:206670" Site order(358..359,376,379) /site_type="other" /note="Switch II region" /db_xref="CDD:206670" Site 427..430 /site_type="other" /note="G4 box" /db_xref="CDD:206670" Site 467..469 /site_type="other" /note="G5 box" /db_xref="CDD:206670" CDS 1..747 /gene="SKI7" /locus_tag="YOR076C" /coded_by="NM_001183495.1:1..2244" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:26051716]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11532933]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:11532933]" /experiment="EXISTENCE:genetic interaction:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:11027292]" /experiment="EXISTENCE:genetic interaction:GO:0030163 protein catabolic process [PMID:27481473]" /experiment="EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429|PMID:12769863]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:11027292|PMID:11532933]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:27481473]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:11532933]" /experiment="EXISTENCE:mutant phenotype:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:11910110|PMID:17660569]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19481524]" /note="GTP-binding protein that couples the Ski complex and exosome; putative pseudo-translational GTPase involved in 3'-to-5' mRNA decay pathway; interacts with both the cytoplasmic exosome and the Ski complex; eRF3-like domain targets nonstop mRNA for degradation; null mutants have a superkiller phenotype; SKI7 has a paralog, HBS1, that arose from the whole genome duplication" /db_xref="GeneID:854243" /db_xref="SGD:S000005602" ORIGIN 1 mslleqlark riekskglls adqshstsks asllerlhkn retkdnnaet krkdlktlla 61 kdkvkrsdft pnqhsvslsl klsalkksns dlekqgksvt ldskenelpt krkspddkln 121 leeswkaike mnhycflknd pcinqtddfa ftnfiikdkk nslstsipls sqnssflslk 181 khnnellgif vpcnlpkttr kvaienfnrp spddiiqsaq lnafneklen lniksvpkae 241 kkepinlqtp ptesidihsf iathplnltc lflgdtnagk stllghllyd lneismssmr 301 elqkkssnld psssnsfkvi ldntkteren gfsmfkkviq vendllppss tltlidtpgs 361 ikyfnketln siltfdpevy vlvidcnyds weksldgpnn qiyeilkvis ylnknsackk 421 hliillnkad liswdkhrle miqselnyvl kenfqwtdae fqfipcsgll gsnlnkteni 481 tkskyksefd sinyvpewye gptffsqlyl lvehnmnkie ttleepfvgt ilqssvlqpi 541 aeinyvslkv linsgyiqsg qtieihtqye dfhyygivsr mknskqilet ntknnisvgl 601 npdilevlvk ihntedftkk qfhirkgdii ihsrktntls pnlpntlkll alrliklsiq 661 thalsdpvdl gselllyhnl thnavklvki lgtndisinp nqslivevei iepdfalnvi 721 dskyitnniv ltsidhkvia vgriacq // LOCUS NP_014720 232 aa linear PLN 30-JUN-2025 DEFINITION Rts2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014720 VERSION NP_014720.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183496.1 REFERENCE 1 (residues 1 to 232) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 232) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 232) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 232) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10856. Method: conceptual translation. FEATURES Location/Qualifiers source 1..232 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..232 /product="Rts2p" /calculated_mol_wt="26923" Region 21..55 /region_name="ZnF_U1" /note="U1-like zinc finger; smart00451" /db_xref="CDD:197732" Region 50..>137 /region_name="Kin17_mid" /note="Domain of Kin17 curved DNA-binding protein; pfam10357" /db_xref="CDD:463057" CDS 1..232 /gene="RTS2" /locus_tag="YOR077W" /coded_by="NM_001183496.1:1..699" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Basic zinc-finger protein; similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication" /db_xref="GeneID:854244" /db_xref="SGD:S000005603" ORIGIN 1 madydsakyw skqgarrglq ktryycqicq rqckdangfq shnkspshlr kisqvtaeda 61 rryniqfekg flqllkqrhg ekwidankvy neyvqdrdhv hmnatmhrsl tqfvrylgra 121 gkvdvdmdid dtsenvegpl lirihpssls spsedgmlrs qqeeqeviaa ellkrqlnra 181 krqtekvyqp emkseisgds tlkrvqvtfh gngrvnkkkk kvpprkdgik fr // LOCUS NP_014721 214 aa linear PLN 30-JUN-2025 DEFINITION Bud21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014721 VERSION NP_014721.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183497.1 REFERENCE 1 (residues 1 to 214) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 214) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 214) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 214) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 214) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10857. Method: conceptual translation. FEATURES Location/Qualifiers source 1..214 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..214 /product="Bud21p" /calculated_mol_wt="24254" Region 111..208 /region_name="U3_snoRNA_assoc" /note="U3 snoRNA associated; pfam08297" /db_xref="CDD:400546" CDS 1..214 /gene="BUD21" /locus_tag="YOR078W" /gene_synonym="UTP16; YOR29-29" /coded_by="NM_001183497.1:1..645" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309|PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15489292]" /note="Component of small ribosomal subunit (SSU) processome; interacts with the U3 snoRNA (Snr17a/b); involved in rRNA processing and maturation; required post-transcriptionally for efficient retrotransposition; absence results in decreased Ty1 Gag:GFP protein levels; originally isolated as bud-site selection mutant that displays a random budding pattern; ortholog of human NOL7" /db_xref="GeneID:854245" /db_xref="SGD:S000005604" ORIGIN 1 msnghvkfda desqasasav tdrqddvlvi skkdkevhss sdeesdddda pqeeglhsgk 61 sevesqitqr eeairleqsq lrskrrkqne lyakqkksvn etevtdevia elpeellkni 121 dqkdegstqy sssrhvtfdk ldesdeneea lakaiktkkr ktlknlrkds vkrgkfrvql 181 lsttqdsktl ppkkessiir skdrwlnrka lnkg // LOCUS NP_014722 313 aa linear PLN 30-JUN-2025 DEFINITION Mn(2+) transporter ATX2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014722 VERSION NP_014722.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183498.1 REFERENCE 1 (residues 1 to 313) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 313) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 313) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 313) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 313) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10858. Method: conceptual translation. FEATURES Location/Qualifiers source 1..313 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..313 /product="Mn(2+) transporter ATX2" /calculated_mol_wt="34277" Region 4..306 /region_name="Zip" /note="ZIP Zinc transporter; pfam02535" /db_xref="CDD:396884" CDS 1..313 /gene="ATX2" /locus_tag="YOR079C" /gene_synonym="YOR29-30" /coded_by="NM_001183498.1:1..942" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:8887660]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:25713143]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:25713143]" /experiment="EXISTENCE:mutant phenotype:GO:0005384 manganese ion transmembrane transporter activity [PMID:8887660]" /experiment="EXISTENCE:mutant phenotype:GO:0030026 intracellular manganese ion homeostasis [PMID:8887660]" /note="Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation" /db_xref="GeneID:854246" /db_xref="SGD:S000005605" ORIGIN 1 mkflgvilla sflliatfli gliplyyidk qkssivtnqe gadsisdftt nadtqtindd 61 vssyrvkiav lsqfgigmll gtsfmlvipe gikacvehdg nvgvnlligf lgvyvldrlv 121 tlwvsrkqtv ythdavkfqs wkdiinhprq iwmnliqnnv vfalfihgls dgialgtttn 181 ndsllivvli aivihkipav lsltslmvsr qnlmkwevic nvflfasstp igyivlslln 241 lshsptmdwi sgnlllmsgg sllyasftaf vggdshdhdl sveqevvlph desvyvligv 301 ciplvisyci see // LOCUS NP_014723 732 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding SCF ubiquitin ligase subunit DIA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014723 VERSION NP_014723.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183499.1 REFERENCE 1 (residues 1 to 732) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 732) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 732) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 732) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 732) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 732) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 732) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 732) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 732) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10859. On May 17, 2010 this sequence version replaced NP_014723.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..732 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..732 /product="DNA-binding SCF ubiquitin ligase subunit DIA2" /calculated_mol_wt="84939" Region 9..>150 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Site order(19..20,23..24,26,71,74,83,86..87,89..90,113,116..117, 120..121,124) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 19..43 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 69..107 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 112..140 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 206..251 /region_name="F-box_ScDIA2-like" /note="F-box domain found in Saccharomyces cerevisiae protein Digs into agar protein 2 (ScDIA2) and similar proteins; cd22142" /db_xref="CDD:438914" Site order(210,214,217..218,221..222,226,228..229,233..235,237) /site_type="other" /note="putative Skp1 binding site [polypeptide binding]" /db_xref="CDD:438914" Region <476..>672 /region_name="LRR" /note="Leucine-rich repeat (LRR) protein [Transcription]; COG4886" /db_xref="CDD:443914" Region 483..511 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 553..581 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 582..618 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 619..647 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" Region 648..673 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275381" CDS 1..732 /gene="DIA2" /locus_tag="YOR080W" /gene_synonym="YOR29-31" /coded_by="NM_001183499.1:1..2199" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16421250]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:19910927]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19858292]" /experiment="EXISTENCE:direct assay:GO:0019005 SCF ubiquitin ligase complex [PMID:16421250|PMID:14747994]" /experiment="EXISTENCE:direct assay:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:19910927]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:19910927]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:11063681]" /experiment="EXISTENCE:genetic interaction:GO:0032984 protein-containing complex disassembly [PMID:26255844]" /experiment="EXISTENCE:mutant phenotype:GO:0006275 regulation of DNA replication [PMID:16421250]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:23129771]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:15620357|PMID:25342810]" /experiment="EXISTENCE:mutant phenotype:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:22844255]" /experiment="EXISTENCE:mutant phenotype:GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [PMID:19910927]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:22844255]" /experiment="EXISTENCE:mutant phenotype:GO:0032984 protein-containing complex disassembly [PMID:26255844|PMID:25342810]" /experiment="EXISTENCE:mutant phenotype:GO:1902979 mitotic DNA replication termination [PMID:25342810]" /note="Origin-binding F-box protein; forms SCF ubiquitin ligase complex with Skp1p and Cdc53p; functions in ubiquitination of silent chromatin structural protein Sir4p; required to target Cdc6p for destruction during G1 phase; required for deactivation of Rad53 checkpoint kinase, completion of DNA replication during recovery from DNA damage, assembly of RSC complex, RSC-mediated transcription regulation, and nucleosome positioning; involved in invasive and pseudohyphal growth" /db_xref="GeneID:854247" /db_xref="SGD:S000005606" ORIGIN 1 msspgnsgva idstvlkaie lgtrlfksge ylqakriftn alrvcdsysq eqimrirnay 61 qldtarpdnk rlyhpryiki ldnicacyek lndlkscldv sqrllklepg nikcyirctr 121 tliklkdwkr ayktcsrglq lcnndsnhlr qqkqfiknnm vqkqdgkrsy idpleetkia 181 kkkknnnvle slpkkkikgs tkktdlvgnl pieilpiifq rfttkelvtl slvcnkwrdk 241 ilyhldcfqe fnlapinfkn fvkfmdflqq nftrtyrkyi lsqvkvssri tseelritql 301 lfskmpkcin ierlilsmpt ltttqifklm vrggtdfftr llelslmity rpdkqhelei 361 lqtcpllkki elifvnslvp ifdgnnsvgr dgsfnvmarh tnmqistadn deqgiveekv 421 iyselekitl icdkkkiknf plcrallrgq fpllqkltit gvtfpmnnqd imnfqwllnf 481 pdlkelwied ndncelskfl qllkfsnvwk nlekltfren klypivnlde dqpvtnddev 541 psmlfykenl qnlekldlmg tsisgsaltr lceqeyldgr klrslnignc pniqfpnnha 601 htarmildvn avlkrlskle einlshlssl ndstmksfii nvpflenlkr ldishnfeit 661 gisiyeflkk fqmdhdneag gqplaylnid gcsqvshitv nmiraqnlvt qvdcvyerdv 721 wrkfginsys ys // LOCUS NP_014724 749 aa linear PLN 30-JUN-2025 DEFINITION triacylglycerol lipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014724 VERSION NP_014724.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183500.1 REFERENCE 1 (residues 1 to 749) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 749) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 749) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 749) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 749) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10860. Method: conceptual translation. FEATURES Location/Qualifiers source 1..749 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..749 /product="triacylglycerol lipase" /EC_number="3.1.1.3" /calculated_mol_wt="84585" Region 40..176 /region_name="DUF3336" /note="Domain of unknown function (DUF3336); pfam11815" /db_xref="CDD:432096" Region 110..537 /region_name="Pat_TGL4-5_like" /note="Triacylglycerol lipase 4 and 5; cd07230" /db_xref="CDD:132868" Site order(188..189,191,216,375) /site_type="active" /db_xref="CDD:132868" Site 214..218 /site_type="other" /note="nucleophile elbow" /db_xref="CDD:132868" CDS 1..749 /gene="TGL5" /locus_tag="YOR081C" /gene_synonym="STC2" /coded_by="NM_001183500.1:1..2250" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:16135509]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:16135509|PMID:24868093|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006642 triglyceride mobilization [PMID:16135509]" /experiment="EXISTENCE:direct assay:GO:0042171 lysophosphatidic acid acyltransferase activity [PMID:20016004]" /experiment="EXISTENCE:mutant phenotype:GO:0004806 triacylglycerol lipase activity [PMID:16135509]" /experiment="EXISTENCE:mutant phenotype:GO:0006642 triglyceride mobilization [PMID:16135509]" /note="Bifunctional triacylglycerol lipase and LPA acyltransferase; lipid particle-localized triacylglycerol (TAG) lipase involved in triacylglycerol mobilization; catalyzes acylation of lysophosphatidic acid (LPA); potential Cdc28p substrate; TGL5 has a paralog, TGL4, that arose from the whole genome duplication" /db_xref="GeneID:854248" /db_xref="SGD:S000005607" ORIGIN 1 msntlpvtef llskyyelsn tpatdssslf kwlyhktlsr kqllisdlss qkkhaisydq 61 wndiasrldd ltglsewkti desslynykl lqdltirmrh lrtthdyhrl lylirtkwvr 121 nlgnmnnvnl yrhshtgtkq iihdyleesq avltalihqs nmndhyllgi lqqtrrnigr 181 talvlsggst fglfhigvla alfesdlmpk visgssagai vasifcvhtt qeipslltnv 241 lnmefnifnd dnskspnenl likisrfcqn gtwfnnqpli ntmlsflgnl tfreaynktg 301 kilnitvspa siyeqpklln nltapnvliw savcascslp gvfpstplfe kdphtgkike 361 wgatnlhlsn mkfmdgsvdn dmpisrlsem fnvdhiiacq vnihvfpllk fsntcvggei 421 ekeitarfrn qvtkifkffs detihfldil kelefhpylm tklkhlflqq ysgnvtilpd 481 lsmvgqfhev lknpsqlfll hqttlgarat wpkismiqnn cgqefaldka itflkekiii 541 sssiknplqf yqprfseqik slsimdadlp gvdleesssn slsiikspnk taapgrfplq 601 plpspsstfn krkmdmlsps pspstspqrs kssftqqgtr qkanslsfai gasslrlkks 661 plkvpsrpqf kkrssyynqn msaemrknrk ksgtissydv qtnsedfpip aiengsfdnt 721 lfnpsrfpmd amsaatndnf mnnsdifqn // LOCUS NP_014726 295 aa linear PLN 30-JUN-2025 DEFINITION transcriptional repressor WHI5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014726 VERSION NP_014726.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183502.1 REFERENCE 1 (residues 1 to 295) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 295) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 295) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 295) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 295) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10861. Method: conceptual translation. FEATURES Location/Qualifiers source 1..295 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..295 /product="transcriptional repressor WHI5" /calculated_mol_wt="32770" Region 181..205 /region_name="Whi5" /note="Whi5 like; pfam08528" /db_xref="CDD:462511" CDS 1..295 /gene="WHI5" /locus_tag="YOR083W" /coded_by="NM_001183502.1:1..888" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:15210111]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24470217|PMID:14562095|PMID:15210111]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15210111|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0033309 SBF transcription complex [PMID:15210110]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:15210111]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:15210110|PMID:15210111|PMID:19823668]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15210110|PMID:15210111]" /experiment="EXISTENCE:genetic interaction:GO:0003714 transcription corepressor activity [PMID:19745812]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:15210111|PMID:15210110]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:15210110|PMID:15210111]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:19745812]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:40365021]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:26390151]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:40365021]" /note="Repressor of G1 transcription; binds SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation by G1 cyclin/Cdc28p relieves repression and promoter binding by Whi5p, drives nuclear export, and contributes to the determination of critical cell size at START and cell fate; dephosphorylated and re-imported into the nucleus post-START during the starvation response, reversing commitment; repressed in M/early G phase; autophagy regulator and Atg1p substrate; functional Rb homolog" /db_xref="GeneID:854249" /db_xref="SGD:S000005609" ORIGIN 1 mslrtpkrsr tsdeqeqeqe qeqvqnpdth vnnehqqrpg pttllstpvr lkngfgtpsp 61 psppgitksi tksrrrpstt slqgifmspv nkrrvgitah grvydhnddg hesesedden 121 eeenenqkky dghvsmpllp pttpksrrse vflspsprlr spptaarrst gerpireish 181 tlrtrlnyal vklqngwtdk tlpeletela pavqtpprry hnrfpdsada gtsahtaflq 241 algghppree atavetlmll ssptkkqqhr pvpatsagep tdetepesdt evets // LOCUS NP_014727 387 aa linear PLN 30-JUN-2025 DEFINITION triglyceride lipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014727 VERSION NP_014727.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183503.1 REFERENCE 1 (residues 1 to 387) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 387) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 387) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 387) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 387) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10862. Method: conceptual translation. FEATURES Location/Qualifiers source 1..387 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..387 /product="triglyceride lipase" /calculated_mol_wt="43596" Region 55..343 /region_name="MenH" /note="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; COG0596" /db_xref="CDD:440361" CDS 1..387 /gene="LPX1" /locus_tag="YOR084W" /coded_by="NM_001183503.1:1..1164" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:24187129]" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:12135984]" /experiment="EXISTENCE:genetic interaction:GO:0019433 triglyceride catabolic process [PMID:24187129]" /note="Peroxisomal matrix-localized lipase; required for normal peroxisome morphology; contains a peroxisomal targeting signal type 1 (PTS1) and a lipase motif; peroxisomal import requires the PTS1 receptor, Pex5p and self-interaction; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; oleic acid inducible" /db_xref="GeneID:854251" /db_xref="SGD:S000005610" ORIGIN 1 meqnrfkket ktcsaswpra pqstlcatdr leltydvyts aerqrrsrta trlnlvflhg 61 sgmskvvwey ylprlvaada egnyaidkvl lidqvnhgds avrnrgrlgt nfnwidgard 121 vlkiatcelg sidshpalnv vighsmggfq alacdvlqpn lfhlliliep vvitrkaiga 181 grpglppdsp qipenlynsl rlktcdhfan eseyvkymrn gsfftnahsq ilqniidfer 241 tkasgddedg gpvrtkmeqa qnllcymnmq tfapflisnv kfvrkrtihi vgarsnwcpp 301 qnqlflqktl qnyhldvipg gshlvnveap dlvierinhh ihefvltspl qsshipqltl 361 eeravmfdra fdsfknealv kttkqkl // LOCUS NP_014728 350 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-diphosphooligosaccharide--protein glycotransferase OST3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014728 VERSION NP_014728.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183504.1 REFERENCE 1 (residues 1 to 350) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 350) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 350) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 350) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 350) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10863. Method: conceptual translation. FEATURES Location/Qualifiers source 1..350 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..350 /product="dolichyl-diphosphooligosaccharide--protein glycotransferase OST3" /calculated_mol_wt="39352" Region 26..340 /region_name="OST3_OST6" /note="OST3 / OST6 family, transporter family; pfam04756" /db_xref="CDD:461420" CDS 1..350 /gene="OST3" /locus_tag="YOR085W" /coded_by="NM_001183504.1:1..1053" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]" /experiment="EXISTENCE:direct assay:GO:0015035 protein-disulfide reductase activity [PMID:23416356]" /experiment="EXISTENCE:genetic interaction:GO:0006487 protein N-linked glycosylation [PMID:10358084]" /experiment="EXISTENCE:genetic interaction:GO:0035269 protein O-linked mannosylation [PMID:22492205]" /experiment="EXISTENCE:mutant phenotype:GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity [PMID:7622558]" /experiment="EXISTENCE:mutant phenotype:GO:0006486 protein glycosylation [PMID:7622558]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:28598353]" /experiment="EXISTENCE:mutant phenotype:GO:0016020 membrane [PMID:7622558]" /experiment="EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]" /experiment="EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]" /note="Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins including modification of Pmt2p at N131 and N403" /db_xref="GeneID:854252" /db_xref="SGD:S000005611" ORIGIN 1 mnwlflvslv ffcgvsthpa lamssnrllk lankspkkii plkdssfeni lapphenayi 61 valftatape igcslclele seydtivasw fddhpdakss nsdtsifftk vnledpskti 121 pkafqffqln nvprlfifkp nspsildhsv isistdtgse rmkqiiqaik qfsqvndfsl 181 hlpmdwtpii tstiitfitv llfkkqsklm fsiissriiw atlstffiic misaymfnqi 241 rntqlagvgp kgevmyflpn efqhqfaiet qvmvliygtl aalvvvlvkg iqflrshlyp 301 etkkayfida ilasfcalfi yvffaalttv ftikspaypf pllrlsapfk // LOCUS NP_014729 1186 aa linear PLN 30-JUN-2025 DEFINITION tricalbin [Saccharomyces cerevisiae S288C]. ACCESSION NP_014729 VERSION NP_014729.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183505.1 REFERENCE 1 (residues 1 to 1186) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1186) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1186) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1186) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1186) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10864. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1186 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1186 /product="tricalbin" /calculated_mol_wt="133445" Region 1..1182 /region_name="COG5038" /note="Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]" /db_xref="CDD:227371" CDS 1..1186 /gene="TCB1" /locus_tag="YOR086C" /coded_by="NM_001183505.1:1..3561" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:15049706]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:22250200]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0055091 phospholipid homeostasis [PMID:35440494]" /experiment="EXISTENCE:genetic interaction:GO:0060304 regulation of phosphatidylinositol dephosphorylation [PMID:23237950]" /experiment="EXISTENCE:genetic interaction:GO:0090158 endoplasmic reticulum membrane organization [PMID:23237950]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:33205016]" /note="Lipid-binding ER tricalbin involved in ER-plasma membrane tethering; one of at least 7 proteins (Ice2p, Ist2p, Scs2/Scs22p, Tcb1-Tcb3p) that affect cER tethering and contact with the plasma membrane (PM); regulates PI4P levels by controlling access of the Sac1p phosphatase to its substrate PI4P in the PM; regulates PM phospholipid homeostasis; contains 3 calcium and lipid binding domains; localizes to the cortical ER and to mitochondria; C-termini of Tcb1p, Tcb2p and Tcb3p interact" /db_xref="GeneID:854253" /db_xref="SGD:S000005612" ORIGIN 1 makedtgvta pkkpetaqva ningidklep pktkeetess ksvssekaah asdesfkrsi 61 heasyvgwkq iggwedkdel tlddelmdmt retfldniip dslygdwyhs vaiffiggva 121 sfalghykfs mgsaffvivi tsllyrtsak kyrgsirelv qkeftvqkve ndyeslewln 181 afldkywpil epsvsqlivq qaneqmatne aipkfitqlw ideltlgvkp prvdlvktfq 241 ntasdvvvmd wgisftphdl cdmsakqvrn yvnelavvka kifgitipvs vsdiafkaha 301 rvkfklmtpf phvetvniql lkvpdfdfva tlfgrsifnw eilaipglmt liqkmakkym 361 gpillppfsl qlnipqllsg snlsigilei tvknakglkr tssilnesid pylsfefndi 421 siaktrtvrd tlnpvwdetl yvllnsftdp ltisvydkra klkdkvlgri qynlntlhdk 481 ttqrnlkaqf lrnskpvgel tfdlrffptl eekklpdgsv eelpdlntgi akvvveegsr 541 faeeeqkvta yvevylnakl vlttgkatdt gtlkwnsdye aviadrrktr ykfvvkdgkg 601 eeigstiqtl ndlidrsqvn knliplknqk gdikittywr pvrleigsns vaytppigai 661 rvfiekandl rnlekfgtid pyckvlvngl skgrtdfksq tlnpvwnqvi yvavtspnqr 721 itlqcmdvet vnkdrslgef nvnvqdlfkk dendkyeeti dekakvgrlv mpkkkpkgti 781 tyytsfypal pvltleeiqd ldkvnkkkka lelrksaide kkiskedkak fdqewnevke 841 ledmysnrqk ldlpellqyn qgvlavtvln gelpdsglyv qaffddnghp rfvspripsr 901 ivkngwsgdv iikeldksit tfrvaknkny nrvekcvcev elptqelvkn cyykpsilhl 961 sgegsaklml qiswfpidtk qlpandlitn sgdltimsrs aenliasdln gysdpylkyy 1021 inneedcayk tkvvkktlnp kwndegtiqi nnrlndvlri kvmdwdstsa ddtigtaeip 1081 lnkvkvegtt eldvpvegle nagqdggmlh lafsfkpryt isvskrekkv gdiaskglgt 1141 glkagttvig ggvgaigkik kgvfgglgsl tnhkknhemg eeetkf // LOCUS NP_014730 675 aa linear PLN 30-JUN-2025 DEFINITION Yvc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014730 VERSION NP_014730.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183506.1 REFERENCE 1 (residues 1 to 675) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 675) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 675) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 675) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 675) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10865. On Jan 21, 2003 this sequence version replaced NP_014730.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..675 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..675 /product="Yvc1p" /calculated_mol_wt="77822" Region 235..470 /region_name="Ion_trans" /note="Ion transport protein; pfam00520" /db_xref="CDD:459842" CDS 1..675 /gene="YVC1" /locus_tag="YOR087W" /gene_synonym="YOR088W" /coded_by="NM_001183506.1:1..2028" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11781332|PMID:11427713]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:20035756|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005227 calcium-activated cation channel activity [PMID:1700419]" /experiment="EXISTENCE:direct assay:GO:0005244 voltage-gated monoatomic ion channel activity [PMID:1700419]" /experiment="EXISTENCE:direct assay:GO:0005262 calcium channel activity [PMID:11781332]" /experiment="EXISTENCE:direct assay:GO:0005267 potassium channel activity [PMID:1700419]" /experiment="EXISTENCE:direct assay:GO:0005272 sodium channel activity [PMID:1700419]" /experiment="EXISTENCE:direct assay:GO:0030003 intracellular monoatomic cation homeostasis [PMID:11427713|PMID:11781332]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:11781332|PMID:11427713]" /experiment="EXISTENCE:mutant phenotype:GO:0097553 calcium ion transmembrane import into cytosol [PMID:27708136]" /note="Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock" /db_xref="GeneID:854255" /db_xref="SGD:S000005613" ORIGIN 1 mvsangdlhl pisneqcmpe nngslgfeap tprqilrvtl nlkylidkvv pivydpndiv 61 cdhseilspk vvklayeacg gnpkdkankr kyqsviifsl lkvcewysil atmevhnakl 121 yetrnlasqq lckllieree trdlqflfmq lllrryvine ndedqeplna lelatdmhct 181 tvigssgfqr clkwiwrgwi vqngldpttf ikddslaevs lishfnpvrl kapvyqnylq 241 mifsflflgl ytlvvngkds ervqsfdlle sifyvfntgf ildeltklyy igyahlsfwn 301 lfndttylii tfamgframs vtplnakyss edwdkisyrv lscaapfvws rlllylesqr 361 figimlvilk hmmkesivff fllflimigf tqgflgldsa dgkrditgpi lgnltitvlg 421 lgsfdvfeef appyaailyy gyyfivsvil lnilialyst ayqkvidnad deymalmsqk 481 tlryirapde dvyvsplnli evfmtpifri lppkrakdls ytvmtivysp flllisvket 541 rearrikynr mkrlnddane ydtpwdltdg ylddddglfs dnrnsgmrat qlknsrslkl 601 qrtaeqedvh fkvpkkwykn vkkcspsfeq ydnddtedda gedkdevkel tkkvenltav 661 itdllekldi kdkke // LOCUS NP_014732 210 aa linear PLN 30-JUN-2025 DEFINITION Rab family GTPase VPS21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014732 VERSION NP_014732.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183508.1 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10866. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..210 /product="Rab family GTPase VPS21" /calculated_mol_wt="22950" Region 7..172 /region_name="Rab5_related" /note="Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion; cd01860" /db_xref="CDD:206653" Site 7..9 /site_type="other" /note="Rab subfamily motif 1 (RabSF1)" /db_xref="CDD:206653" Site 14..21 /site_type="other" /note="G1 box" /db_xref="CDD:206653" Site order(16..22,32..33,38..39,65,120..121,123,153..155) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206653" Site order(22..33,37..38) /site_type="other" /note="Rab subfamily motif 2 (RabSF2)" /db_xref="CDD:206653" Site order(32,37..45) /site_type="other" /note="Switch I region" /db_xref="CDD:206653" Site order(37,41..48,55,57) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206653" Site 39 /site_type="other" /note="G2 box" /db_xref="CDD:206653" Site order(40..41,43,61..62,69,71,73..75) /site_type="other" /note="putative GDI interaction site [polypeptide binding]" /db_xref="CDD:206653" Site 40..44 /site_type="other" /note="Rab family motif 1 (RabF1)" /db_xref="CDD:206653" Site order(42..44,46,68,75..76) /site_type="active" /note="effector interaction site [active]" /db_xref="CDD:206653" Site 57..61 /site_type="other" /note="Rab family motif 2 (RabF2)" /db_xref="CDD:206653" Site 62..65 /site_type="other" /note="G3 box" /db_xref="CDD:206653" Site order(65,67..77) /site_type="other" /note="Switch II region" /db_xref="CDD:206653" Site 68..73 /site_type="other" /note="Rab family motif 3 (RabF3)" /db_xref="CDD:206653" Site 76..77 /site_type="other" /note="Rab family motif 4 (RabF4)" /db_xref="CDD:206653" Site 85..90 /site_type="other" /note="Rab family motif 5 (RabF5)" /db_xref="CDD:206653" Site 112..117 /site_type="other" /note="Rab subfamily motif 3 (RabSF3)" /db_xref="CDD:206653" Site 120..123 /site_type="other" /note="G4 box" /db_xref="CDD:206653" Site 153..155 /site_type="other" /note="G5 box" /db_xref="CDD:206653" Site 169..171 /site_type="other" /note="Rab subfamily motif 4 (RabSF4)" /db_xref="CDD:206653" CDS 1..210 /gene="VPS21" /locus_tag="YOR089C" /gene_synonym="VPS12; VPT12; YPT21; YPT51" /coded_by="NM_001183508.1:1..633" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:11210571]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005769 early endosome [PMID:31754649]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:23612966|PMID:22748138]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:22748138]" /experiment="EXISTENCE:genetic interaction:GO:0036010 protein localization to endosome [PMID:23264632]" /experiment="EXISTENCE:genetic interaction:GO:0036258 multivesicular body assembly [PMID:22748138]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:1493335]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:8163546]" /experiment="EXISTENCE:mutant phenotype:GO:0005770 late endosome [PMID:11872141]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:8163546]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:22748138|PMID:23612966]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:8163546]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]" /note="Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication" /db_xref="GeneID:854256" /db_xref="SGD:S000005615" ORIGIN 1 mntsvtsikl vllgeaavgk ssivlrfvsn dfaenkepti gaafltqrvt inehtvkfei 61 wdtagqerfa slapmyyrna qaalvvydvt kpqsfikarh wvkelheqas kdiiialvgn 121 kidmlqegge rkvareegek laeekgllff etsaktgenv ndvflgigek iplktaeeqn 181 sasneresnn qrvdlnaand gtsansacsc // LOCUS NP_014733 572 aa linear PLN 30-JUN-2025 DEFINITION type 2C protein phosphatase PTC5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014733 VERSION NP_014733.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183509.1 REFERENCE 1 (residues 1 to 572) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 572) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 572) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 572) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10867. Method: conceptual translation. FEATURES Location/Qualifiers source 1..572 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..572 /product="type 2C protein phosphatase PTC5" /EC_number="3.1.3.43" /calculated_mol_wt="63538" Site order(162,166..167,197..199,424) /site_type="active" /db_xref="CDD:238083" Region 182..464 /region_name="PP2C" /note="Protein phosphatase 2C; pfam00481" /db_xref="CDD:395385" CDS 1..572 /gene="PTC5" /locus_tag="YOR090C" /gene_synonym="PPP1" /coded_by="NM_001183509.1:1..1719" /experiment="EXISTENCE:direct assay:GO:0004722 protein serine/threonine phosphatase activity [PMID:10580002]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961|PMID:16643908]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:32398688]" /experiment="EXISTENCE:mutant phenotype:GO:0004741 [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity [PMID:18180296]" /experiment="EXISTENCE:mutant phenotype:GO:0070262 peptidyl-serine dephosphorylation [PMID:18180296]" /note="Mitochondrial type 2C protein phosphatase (PP2C); involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p" /db_xref="GeneID:854257" /db_xref="SGD:S000005616" ORIGIN 1 mspltrtvai kktvkvlskc qsgreytqkf lqraystsha nstyysrtkl fisshskaln 61 iallsgslll tysyyspkki lsldtingik dystntsgni nmpspnpkgt etqksqrsqn 121 dqsvlilnds kieaklhdre eshfvnrgtg ifrydvaqlp snhpieddhv eqiitipies 181 edgksiekdl yffgifdghg gpftseklsk dlvryvayql gqvydqnktv fhsdpnqlid 241 saiskgflkl dndlviesfr klfqdpnntn iantlpaisg scallslyns tnsilkvavt 301 gdsralicgl dnegnwtvks lstdqtgdnl devrrirkeh pgepnvirng rilgslqpsr 361 afgdyrykik evdgkplsdl pevaklyfrr eprdfktppy vtaepvitsa kigentkfmv 421 mgsdglfell tneeiaslvi rwmdknmnla pvkaepgklp kvidvsedke aqrpafrykd 481 nnssspsgsn peyliedknv athlirnals aggrkeyvsa lvsipspmsr ryrddltvtv 541 affgdsgtps ivsnatsivm npeattkpkp rl // LOCUS NP_014734 345 aa linear PLN 30-JUN-2025 DEFINITION translation machinery-associated protein TMA46 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014734 VERSION NP_014734.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183510.1 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10868. On Dec 12, 2005 this sequence version replaced NP_014734.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..345 /product="translation machinery-associated protein TMA46" /calculated_mol_wt="39383" Region 1..336 /region_name="COG5252" /note="Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]" /db_xref="CDD:227577" CDS 1..345 /gene="TMA46" /locus_tag="YOR091W" /coded_by="NM_001183510.1:1..1038" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:genetic interaction:GO:0002181 cytoplasmic translation [PMID:21076151]" /note="hypothetical protein that associates with translating ribosomes; interacts with GTPase Rbg1p" /db_xref="GeneID:854258" /db_xref="SGD:S000005617" ORIGIN 1 mppkkgkqaq aagkkkdnvd ktfgmknknr stkvqkyikq vqsqsdpkke emrlkkleek 61 krreaeeaer ralfnpvadq rvragvdpks mvcalfklgn cnkgakckfs hdlnvgrrme 121 kkdlyqdtrs ekendtmdnw deeklrkvil skhgnpkttt dkvckyfiea vengkygwfw 181 icpnggdkcm yrhslpegfv lktneqkrle reslekqpki tleefieter gkldkskltp 241 itianfaqwk kdhviakina ekklsskrkp tgreiilkms aenksfetdn admpddvtqg 301 sawdlteftd alkkadhqdd ggikdygdgs nptfdikkan satla // LOCUS NP_014735 613 aa linear PLN 30-JUN-2025 DEFINITION putative ATPase ECM3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014735 VERSION NP_014735.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183511.1 REFERENCE 1 (residues 1 to 613) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 613) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 613) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 613) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 613) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10869. Method: conceptual translation. FEATURES Location/Qualifiers source 1..613 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..613 /product="putative ATPase ECM3" /calculated_mol_wt="67884" Region 17..>161 /region_name="YfdV" /note="Predicted permease, AEC (auxin efflux carrier) family [General function prediction only]; COG0679" /db_xref="CDD:440443" CDS 1..613 /gene="ECM3" /locus_tag="YOR092W" /gene_synonym="YOR3165W" /coded_by="NM_001183511.1:1..1842" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:22842922|PMID:14562095]" /note="Non-essential hypothetical protein; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation; relocalizes from ER to cytoplasm upon DNA replication stress; ECM3 has a paralog, YNL095C, that arose from the whole genome duplication" /db_xref="GeneID:854259" /db_xref="SGD:S000005618" ORIGIN 1 mthitlgqai wasvrpiiki yliigvgfgl ckmniltvqa trsisdivlt illpclsfnk 61 ivaniedndi kdvgiiclts vilfatglgf afivrsvlpv pkrwrggila ggmfpnisdl 121 piaylqsmdq gfifteaege kgvanviifl amflicvfnl ggfrliendf hykgdddeen 181 tltnddsaqq ptqpiegnss sssnqdilke pnestvpnss qasyiseknk kektelsvpk 241 pthtappaid drssnssavv sidsithslr tnhvdaqsvs elndptyrtr sqpiayttes 301 rtshvhnnrr nsitgslrsi dmrelpaegm sdlireysnv dqygrrrkss issqgapsvl 361 qadgtispnl trtstlqrvk tsnltriits datvskkdie tsgsslpkwl qkfpltkffv 421 fflknclrpc smavilalii afipwvkalf vttsntpkik qapdnapalt fimdftsyvg 481 aasvpfglil lgatlgrlki gklypgfwks avvlvflrqc impifgvlwc drlvkagwln 541 wendkmllfv taitwnlptm ttliyftasy tpedetepvq mectsfflml qyplmvvslp 601 flvsyfikvq mkl // LOCUS NP_014736 1648 aa linear PLN 30-JUN-2025 DEFINITION Cmr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014736 VERSION NP_014736.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183512.1 REFERENCE 1 (residues 1 to 1648) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1648) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1648) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1648) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1648) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10870. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1648 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1648 /product="Cmr2p" /calculated_mol_wt="186777" Region 5..121 /region_name="DMAP_binding" /note="DMAP1-binding Domain; pfam06464" /db_xref="CDD:368923" Region 179..893 /region_name="Adenylate forming domain, Class I superfamily" /note="This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate...; cl17068" /db_xref="CDD:473059" Site order(332,335..340,342..343) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341228" Site order(335,486..487,507..510,515..516,687,727,746,761,878) /site_type="other" /note="AMP binding site [chemical binding]" /db_xref="CDD:341228" Site order(335,400..401,454,456..457,460,486..487,507..510, 515..516,687,727,746,758..761,857) /site_type="active" /db_xref="CDD:341228" Site order(400,456..457,460,486,758..760,844,857) /site_type="other" /note="CoA binding site [chemical binding]" /db_xref="CDD:341228" Region 1004..1626 /region_name="Dip2" /note="Disco-interacting protein 2 (Dip2); cd05905" /db_xref="CDD:341231" Site order(1174,1177..1182,1184..1185) /site_type="other" /note="putative acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341231" Site order(1177,1321..1322,1376..1381,1482,1506,1509,1520,1606) /site_type="other" /note="putative AMP binding site [chemical binding]" /db_xref="CDD:341231" Site order(1177,1220..1221,1271,1273..1274,1277,1321..1322, 1339..1344,1482,1506,1509,1517..1520,1581) /site_type="active" /note="putative active site [active]" /db_xref="CDD:341231" Site order(1220,1273..1274,1277,1321,1517..1519,1568,1581) /site_type="other" /note="putative CoA binding site [chemical binding]" /db_xref="CDD:341231" CDS 1..1648 /gene="CMR2" /locus_tag="YOR093C" /gene_synonym="DIP2" /coded_by="NM_001183512.1:1..4947" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:35766356]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:35766356]" /experiment="EXISTENCE:mutant phenotype:GO:0046339 diacylglycerol metabolic process [PMID:35766356]" /experiment="EXISTENCE:mutant phenotype:GO:0097576 vacuole fusion [PMID:35766356]" /note="Protein involved in regulation of diacylglycerol lipids levels; deletion causes sensitivity to unfolded protein response-inducing agents" /db_xref="GeneID:854260" /db_xref="SGD:S000005619" ORIGIN 1 mdfsipptlp ldlqsrlnel iqdykdenlt rkgyetkrkq lldkfeisqm rpytplrspn 61 srkskhlhrr ntslassits lpnsidrrhs iyrvttinst sanntprrrs krytaslqss 121 lpgssdengs vkdavynpmi pllprhtgae ntssgdsamt dslplilrgr fehydgqtam 181 isinskgket fitwdklylk aervahelnk shlykmdkil lwynkndvie ftiallgcfi 241 sgmaavpvsf etyslreile iikvtnskfv lisnachrql dnlysssnhs kvklvkndvf 301 qqikfvktdd lgtytkakkt sptfdipnis yieftrtplg rlsgvvmkhn ilinqfetmt 361 kilnsrsmph wkqksqsirk pfhkkimatn srfvilnsld ptrstglimg vlfnlftgnl 421 misidssilq rpggyeniid kfradillnd qlqlkqvvin ylenpesafs kkhkidfsci 481 kscltsctti dtdvsemvvh kwlknlgcid apfcyspmlt lldfggifis irdqlgnlen 541 fpihnsklrl qnelfinrek lklnevecsi taminssssf kdylkletfg fpipditlcv 601 vnpdtntlvq dltvgeiwis snhitdefyq mdkvnefvfk aklnysemfs wakyemptne 661 ksqavteqld tilnicpant yfmrtklmgf vhngkiyvls liedmflqnr lirlpnwaht 721 snllyakkgn qsaqpkgntg aestkaidis slsgetssgy krvveshylq qitetvvrtv 781 ntvfevaafe lqhhkeehfl vmvvesslak teeesknget tdttlmkfae tqrnkletkm 841 ndltdqifri lwifhkiqpm cilvvprdtl prrycslela nstvekkfln ndlsaqfvkf 901 qfdnvildfl phsayynesi lsehlsklrk malqeeyami epayrnggpv kpklalqcsg 961 vdyrdesvdt rshtkltdfk sileilewri snygnetafs dgtntnlvns sasndnnvhk 1021 kvswasfgki vagflkkivg skiplkhgdp iiimcensve yvamimacly cnllviplps 1081 vkesvieedl kglvniiqsy kvkrvfvdak lhsllndnnv vnkcfkkyks lipkitvfsk 1141 vktknaltvs mfknvlkqkf gakpgtrigm tpcvvwvnte ydvtsnihvt mthssllnas 1201 kivketlqlr nnsplfsics htsglgfmfs cllgiytgas tclfsltdvl tdpkefligl 1261 qnlnvkdlyl kletlyalld rassliegfk nkkeninsak nntsgslred vfkgvrnimi 1321 pfpnrpriyt ienilkryst islsctqisy vyqhhfnpli slrsyldipp vdlyldpfsl 1381 regiirevnp ndvsagnyik iqdsgvvpvc tdvsvvnpet llpcvdgefg eiwccseana 1441 fdyfvcnssk nklykdpfit eqfkskmkse vnntlsylrt gdlgfiknvs ctnsqgevvn 1501 lnllfvlgsi hesieilglt hfvsdlertv kdvhsdigsc liakaggllv clirckerhn 1561 pilgnlttli vsellnkhgv ildlctfvrt kgispknssm imevwaknra simqawfdqk 1621 iqieaqfgin ygenisiyll sdyekdni // LOCUS NP_014737 183 aa linear PLN 30-JUN-2025 DEFINITION Arf family GTPase ARF3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014737 VERSION NP_014737.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183513.1 REFERENCE 1 (residues 1 to 183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 183) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10871. Method: conceptual translation. FEATURES Location/Qualifiers source 1..183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..183 /product="Arf family GTPase ARF3" /calculated_mol_wt="20565" Region 9..177 /region_name="Arf6" /note="ADP ribosylation factor 6 (Arf6); cd04149" /db_xref="CDD:206716" Site 24..31 /site_type="other" /note="G1 box" /db_xref="CDD:206716" Site order(26..27,31,35,47..54,76,81) /site_type="other" /note="putative GAP interaction site [polypeptide binding]" /db_xref="CDD:206716" Site order(27..32,45,48,70,126..127,129,160..161) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206716" Site 36..51 /site_type="other" /note="Switch I region" /db_xref="CDD:206716" Site 41..42 /site_type="active" /note="QS Arf6 conserved motif [active]" /db_xref="CDD:206716" Site order(48..52,57,67,71,77,79..81) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206716" Site 48 /site_type="other" /note="G2 box" /db_xref="CDD:206716" Site order(49..56,66,77,80..81) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206716" Site 51..66 /site_type="active" /note="interswitch region [active]" /db_xref="CDD:206716" Site 67..70 /site_type="other" /note="G3 box" /db_xref="CDD:206716" Site 69..84 /site_type="other" /note="Switch II region" /db_xref="CDD:206716" Site 126..129 /site_type="other" /note="G4 box" /db_xref="CDD:206716" Site 160..162 /site_type="other" /note="G5 box" /db_xref="CDD:206716" CDS 1..183 /gene="ARF3" /locus_tag="YOR094W" /gene_synonym="ARL2" /coded_by="NM_001183513.1:1..552" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8063710]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17786213]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:17786213]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:18208507]" /experiment="EXISTENCE:genetic interaction:GO:0051017 actin filament bundle assembly [PMID:17425670]" /experiment="EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:17425670|PMID:14668359]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:12972567]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:23783029]" /experiment="EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:8063710]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:18208507]" /experiment="EXISTENCE:mutant phenotype:GO:0008047 enzyme activator activity [PMID:23783029]" /experiment="EXISTENCE:mutant phenotype:GO:0010513 positive regulation of phosphatidylinositol biosynthetic process [PMID:18208507]" /experiment="EXISTENCE:mutant phenotype:GO:0036267 invasive filamentous growth [PMID:23783029]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:18397879]" /note="Glucose-repressible ADP-ribosylation factor; GTPase of Ras superfamily involved in regulating cell polarity and invasive growth; localizes to dynamic spots at plasma membrane and modulates PtdIns(4,5)P2 levels to facilitate endocytosis; required for localization of endocytic protein Lsb5p to correct cortical site in cells; also has mRNA binding activity; homolog of mammalian Arf6" /db_xref="GeneID:854261" /db_xref="SGD:S000005620" ORIGIN 1 mgnsiskvlg klfgskemki lmlgldkagk ttilyklkln kiktstptvg fnvetvtykn 61 vkfnmwdvgg qqrlrplwrh yfpattalif vidssarnrm eeakeelysi igekemenvv 121 llvwankqdl kdamkpqevs dfleleknlk nqpwcvigsn alsgqglveg lswisnntnv 181 pkk // LOCUS NP_014738 258 aa linear PLN 30-JUN-2025 DEFINITION ribose-5-phosphate isomerase RKI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014738 VERSION NP_014738.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183514.1 REFERENCE 1 (residues 1 to 258) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 258) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 258) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 258) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10872. Method: conceptual translation. FEATURES Location/Qualifiers source 1..258 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..258 /product="ribose-5-phosphate isomerase RKI1" /EC_number="5.3.1.6" /calculated_mol_wt="28127" Region 22..253 /region_name="rpiA" /note="ribose 5-phosphate isomerase; TIGR00021" /db_xref="CDD:272859" Site order(46,80,83..84,93,95,122..123,189..190,200,202,206) /site_type="other" /note="tetramer (dimer of dimers) interface [polypeptide binding]" /db_xref="CDD:238692" Site order(46,48..49,107..108,110,120..123,129,147) /site_type="active" /db_xref="CDD:238692" Site order(96,100,128,135,167..168,170..172,175,226..227,232) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238692" CDS 1..258 /gene="RKI1" /locus_tag="YOR095C" /coded_by="NM_001183514.1:1..777" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004751 ribose-5-phosphate isomerase activity [PMID:8929392]" /experiment="EXISTENCE:mutant phenotype:GO:0006098 pentose-phosphate shunt [PMID:8929392]" /experiment="EXISTENCE:mutant phenotype:GO:0008615 pyridoxine biosynthetic process [PMID:14690456]" /note="Ribose-5-phosphate ketol-isomerase; catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis" /db_xref="GeneID:854262" /db_xref="SGD:S000005621" ORIGIN 1 maagvpkida leslgnpled akraaayrav denlkfddhk iigigsgstv vyvaerigqy 61 lhdpkfyeva skficiptgf qsrnlildnk lqlgsieqyp ridiafdgad evdenlqlik 121 gggaclfqek lvstsaktfi vvadsrkksp khlgknwrqg vpieivpssy vrvkndlleq 181 lhaekvdirq ggsakagpvv tdnnnfiida dfgeisdprk lhreikllvg vvetglfidn 241 askayfgnsd gsvevtek // LOCUS NP_014739 190 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS7 RPS7A [Saccharomyces cerevisiae S288C]. ACCESSION NP_014739 VERSION NP_014739.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183515.1 REFERENCE 1 (residues 1 to 190) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 190) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 190) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 190) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10873. Method: conceptual translation. FEATURES Location/Qualifiers source 1..190 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..190 /product="40S ribosomal protein eS7 RPS7A" /calculated_mol_wt="21491" Region 6..185 /region_name="Ribosomal_S7e" /note="Ribosomal protein S7e; pfam01251" /db_xref="CDD:460135" CDS 1..190 /gene="RPS7A" /locus_tag="YOR096W" /gene_synonym="RPS30" /coded_by="NM_001183515.1:1..573" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:genetic interaction:GO:0042254 ribosome biogenesis [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication" /db_xref="GeneID:854263" /db_xref="SGD:S000005622" ORIGIN 1 msapqakils qaptelelqv aqafvelens spelkaelrp lqfksireid vaggkkalai 61 fvpvpslagf hkvqtkltre lekkfqdrhv iflaerrilp kpsrtsrqvq krprsrtlta 121 vhdkiledlv fpteivgkrv rylvggnkiq kvlldskdvq qidyklesfq avynkltgkq 181 ivfeipseth // LOCUS NP_014740 175 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR097C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014740 VERSION NP_014740.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183516.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10874. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..175 /product="uncharacterized protein" /calculated_mol_wt="19270" CDS 1..175 /locus_tag="YOR097C" /coded_by="NM_001183516.1:1..528" /note="hypothetical protein; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene" /db_xref="GeneID:854264" /db_xref="SGD:S000005623" ORIGIN 1 mdlkrdwlrw kitigsgpgs ivldfpsflv gcvfttmmgp ilqkligkll vglitvckfl 61 viigsivfvi gvaskkytyd dfkvsikrsg epgeshdmrt epkrtaktat vpmekdegvg 121 synyfeipit ketstipyin cdgtsslrkp pngpssvgls nsnryenfin marhk // LOCUS NP_014741 1076 aa linear PLN 30-JUN-2025 DEFINITION FG-nucleoporin NUP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014741 VERSION NP_014741.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183517.1 REFERENCE 1 (residues 1 to 1076) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1076) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1076) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1076) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1076) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1076) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1076) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1076) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1076) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10875. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1076 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1076 /product="FG-nucleoporin NUP1" /calculated_mol_wt="113451" Region 302..>490 /region_name="PTZ00482" /note="membrane-attack complex/perforin (MACPF) Superfamily; Provisional" /db_xref="CDD:240433" Region <458..690 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" Region 853..>1064 /region_name="Nucleoporin_FG2" /note="Nucleoporin FG repeated region; pfam15967" /db_xref="CDD:435043" CDS 1..1076 /gene="NUP1" /locus_tag="YOR098C" /coded_by="NM_001183517.1:1..3231" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:10684247|PMID:2190694|PMID:11046143]" /experiment="EXISTENCE:direct assay:GO:0044613 nuclear pore central transport channel [PMID:18046406]" /experiment="EXISTENCE:direct assay:GO:0044615 nuclear pore nuclear basket [PMID:10684247]" /experiment="EXISTENCE:genetic interaction:GO:0006607 NLS-bearing protein import into nucleus [PMID:15039779]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:11071906]" /experiment="EXISTENCE:mutant phenotype:GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [PMID:20098417|PMID:16760982]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:7929578]" /experiment="EXISTENCE:mutant phenotype:GO:0006607 NLS-bearing protein import into nucleus [PMID:11046143|PMID:16118201]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:7929578|PMID:12411502|PMID:16118201]" /experiment="EXISTENCE:mutant phenotype:GO:0017056 structural constituent of nuclear pore [PMID:17418788]" /experiment="EXISTENCE:physical interaction:GO:0017056 structural constituent of nuclear pore [PMID:17418788|PMID:12917401|PMID:10525531]" /note="FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of thenuclear pore complex (NPC) permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153" /db_xref="GeneID:854265" /db_xref="SGD:S000005624" ORIGIN 1 mssntssvms sprvekrsfs stlksfftnp nkkrpsskkv fssnlsyanh leesdvedtl 61 hvnkrkrvsg tsqhsdsltq nnnnapiiiy gtenterppl lpilpiqrlr llrekqrvrn 121 mrelgliqst efpsitssvi lgsqsksdeg gsylctsstp spikngsctr qlagksgedt 181 nvglpilksl knrsnrkrfh sqskgtvwsa nfeydlseyd aiqkkdnkdk egnaggdqkt 241 senrnnikss isngnlatgp nltseiedlr adinsnrlsn pqknlllkgp astvaktapi 301 qesfvpnser sgtptlkkni epkkdkesiv lptvgfdfik dnetpskkts pkatssagav 361 fkssvemgkt dkstktaeap tlsfnfsqka nktkavdntv psttlfnfgg ksdtvtsasq 421 pfkfgktsek senhtesdap pkstapifsf gkqeengdeg ddenepkrkr rlpvsedtnt 481 kplfdfgktg dqketkkges ekdasgkpsf vfgasdkqae gtplftfgkk advtsnidss 541 aqftfgkaat akethtkpse tpativkkpt ftfgqstsen kisegsakpt fsfskseeer 601 ksspisneaa kpsfsfpgkp vdvqaptddk tlkptfsfte paqkdssvvs epkkpsftfa 661 ssktsqpkpl fsfgksdaak eppgsntsfs ftkppanetd krptppsftf ggsttnnttt 721 tstkpsfsfg apesmkstas taaantekls ngfsftkfnh nkeksnspts ffdgsasstp 781 ipvlgkptda tgnttsksaf sfgtantngt nasanstsfs fnapatgngt tttsntsgtn 841 iagtfnvgkp dqsiasgntn gagsafgfss sgtaatgaas nqssfnfgnn gagglnpfts 901 atsstnanag lfnkppstna qnvnvpsafn ftgnnstpgg gsvfnmngnt nantvfagsn 961 nqphqsqtps fntnssftps tvpninfsgl nggitntatn alrpsdifga naasgsnsnv 1021 tnpssifgga ggvpttsfgq pqsapnqmgm gtnngmsmgg gvmanrkiar mrhskr // LOCUS NP_014742 393 aa linear PLN 30-JUN-2025 DEFINITION alpha-1,2-mannosyltransferase KTR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014742 VERSION NP_014742.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183518.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10876. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..393 /product="alpha-1,2-mannosyltransferase KTR1" /calculated_mol_wt="45891" Region 1..389 /region_name="KTR1" /note="Mannosyltransferase [Carbohydrate transport and metabolism]; COG5020" /db_xref="CDD:227353" CDS 1..393 /gene="KTR1" /locus_tag="YOR099W" /coded_by="NM_001183518.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:9020857]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8631921]" /experiment="EXISTENCE:genetic interaction:GO:0006487 protein N-linked glycosylation [PMID:9182588]" /experiment="EXISTENCE:genetic interaction:GO:0006493 protein O-linked glycosylation [PMID:9182588]" /experiment="EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:9182588]" /note="Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress" /db_xref="GeneID:854266" /db_xref="SGD:S000005625" ORIGIN 1 makimipask qpvykklgll lvavftvyvf fhgaqyargs apspkystvl ssgsgykysk 61 velpkytgpr ekatfvtlvr nrdlyslaes iksvedrfns kfnydwvfln deeftdefkn 121 vtsalvsgtt kygvipkehw sfpewideek aaqvrkemge kriiygdsis yrhmcrfesg 181 ffyrhplmdd ydwywrvepd iklhcdidyd vfkfmkdnkk kyafaisike yeatiptlwe 241 ttrkfmeahp elihennmld fvsddqglsy nlchfwsnfe iaaldlwrsp aysayfdyld 301 reggffyerw gdapvhsiga alfldrseih hfgdigyyhv pfhscpidts irlankcdcd 361 pskdftwhsy scttkfynin klpkpagwqn hig // LOCUS NP_014743 327 aa linear PLN 30-JUN-2025 DEFINITION carnitine:acyl carnitine antiporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_014743 VERSION NP_014743.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183519.1 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10877. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..327 /product="carnitine:acyl carnitine antiporter" /calculated_mol_wt="34623" Region 35..131 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 137..222 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 235..326 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..327 /gene="CRC1" /locus_tag="YOR100C" /coded_by="NM_001183519.1:1..984" /experiment="EXISTENCE:direct assay:GO:0005476 carnitine:O-acyl-L-carnitine antiporter activity [PMID:10545096]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:11914276|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10545096]" /experiment="EXISTENCE:direct assay:GO:0006631 fatty acid metabolic process [PMID:10545096]" /experiment="EXISTENCE:direct assay:GO:1902603 carnitine transmembrane transport [PMID:10545096]" /note="Mitochondrial inner membrane carnitine transporter; required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation; human homolog SLC25A20 complements yeast null mutant" /db_xref="GeneID:854267" /db_xref="SGD:S000005626" ORIGIN 1 mssdtslses sllkeesgsl tksrppiksn pvreniksfv aggvggvcav ftghpfdlik 61 vrcqngqans tvhaitniik eaktqvkgtl ftnsvkgfyk gvippllgvt pifavsfwgy 121 dvgkklvtfn nkqggsnelt mgqmaaagfi saipttlvta ptervkvvlq tsskgsfiqa 181 aktivkeggi aslfkgslat lardgpgsal yfasyeiskn ylnsrqprqd agkdepvnil 241 nvclaggiag msmwlavfpi dtiktklqas strqnmlsat keiylqrggi kgffpglgpa 301 llrsfpanaa tflgvemths lfkkygi // LOCUS NP_014744 309 aa linear PLN 30-JUN-2025 DEFINITION Ras family GTPase RAS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014744 VERSION NP_014744.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183520.1 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10878. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..309 /product="Ras family GTPase RAS1" /EC_number="3.6.5.2" /calculated_mol_wt="34216" Region 9..172 /region_name="small_GTPase" /note="Small GTPase of the Ras superfamily; ill-defined subfamily; smart00010" /db_xref="CDD:197466" CDS 1..309 /gene="RAS1" /locus_tag="YOR101W" /coded_by="NM_001183520.1:1..930" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:14674766]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:20162532|PMID:3513173]" /experiment="EXISTENCE:direct assay:GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway [PMID:3891097]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0045762 positive regulation of adenylate cyclase activity [PMID:3891097]" /experiment="EXISTENCE:genetic interaction:GO:0097271 protein localization to bud neck [PMID:12782684]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:6327067]" /note="GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in regulation of cell proliferation; localized to the plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication" /db_xref="GeneID:854268" /db_xref="SGD:S000005627" ORIGIN 1 mqgnkstire ykivvvgggg vgksaltiqf iqsyfvdeyd ptiedsyrkq vviddkvsil 61 dildtagqee ysamreqymr tgegfllvys vtsrnsfdel lsyyqqiqrv kdsdyipvvv 121 vgnkldlene rqvsyedglr lakqlnapfl etsakqainv deafyslirl vrddggkyns 181 mnrqldntne irdseltssa tadrekknng syvldnsltn agtgsssksa vnhngettkr 241 tdeknyvnqn nnnegntkys sngngnrsdi srgnqnnaln srskqsaepq knssanarke 301 ssggcciic // LOCUS NP_014746 130 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-diphosphooligosaccharide-protein glycotransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014746 VERSION NP_014746.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183522.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10879. On Oct 2, 2003 this sequence version replaced NP_014746.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..130 /product="dolichyl-diphosphooligosaccharide-protein glycotransferase" /calculated_mol_wt="14566" Region 24..130 /region_name="DAD" /note="DAD family; pfam02109" /db_xref="CDD:460448" CDS 1..130 /gene="OST2" /locus_tag="YOR103C" /coded_by="NM_001183522.1:1..393" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008250 oligosaccharyltransferase complex [PMID:10358084]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:7593165]" /experiment="EXISTENCE:physical interaction:GO:0006487 protein N-linked glycosylation [PMID:9405463]" /experiment="EXISTENCE:physical interaction:GO:0008250 oligosaccharyltransferase complex [PMID:9405463]" /note="Non-catalytic epsilon subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes asparagine-linked glycosylation of newly synthesized proteins in the ER; forms a pocket with Wbp1p involved in binding terminal glucose units of the donor glycan; located in the ER lumen" /db_xref="GeneID:854270" /db_xref="SGD:S000005629" ORIGIN 1 makapkantp kvtstssavl tdfqetfkts krayfaqiek ypklklidtf cfflvllgvi 61 qctfiilird nfpfnaflag fiicvgqfvl lmslrlqlcn sfpgisknra faefivasli 121 lhfvclhfin // LOCUS NP_014747 282 aa linear PLN 30-JUN-2025 DEFINITION Pin2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014747 VERSION NP_014747.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183523.1 REFERENCE 1 (residues 1 to 282) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 282) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 282) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 282) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 282) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10880. Method: conceptual translation. FEATURES Location/Qualifiers source 1..282 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..282 /product="Pin2p" /calculated_mol_wt="31952" CDS 1..282 /gene="PIN2" /locus_tag="YOR104W" /coded_by="NM_001183523.1:1..849" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:24656818]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:24656818]" /note="Exomer-dependent cargo protein; induces appearance of [PIN+] prion when overproduced; prion-like domain serves as a retention signal in the trans-Golgi network; predicted to be palmitoylated" /db_xref="GeneID:854271" /db_xref="SGD:S000005630" ORIGIN 1 mnvcklkeiv plfprssftd gvvstgksfr swdtcmdnka ckiiaivgiv lacilviwli 61 gglltcfrqg vtgigqficw ccrcsndrng nntmpvnegf srvnmgvapp stviyqpiqq 121 pesayyrnda kndtfydevk tpsnevyele edfdlekqke ktrkkqqker nkegrspsrv 181 aplvyeeenf egsspqpqyd arnsfiqnaa ntgsnnahva sqspifdisd ygenyyydnn 241 ninnnlqgns yntpssnhrs pyptenyqsy qgykpnqsdr yy // LOCUS NP_001257690 108 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR105W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001257690 VERSION NP_001257690.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001270761.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA35137. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..108 /product="uncharacterized protein" /calculated_mol_wt="12204" CDS 1..108 /locus_tag="YOR105W" /coded_by="NM_001270761.1:1..327" /note="hypothetical protein; expressed at both mRNA and protein levels" /db_xref="GeneID:854272" /db_xref="SGD:S000005631" ORIGIN 1 mkkkiskvaa lsrnmmleir lskmrpilva ttlmllhnlq fltsaimart iitiiitsii 61 tsretvtilp pliievhiqp kiinhirdin qtkaiditne vniyspff // LOCUS NP_014749 283 aa linear PLN 30-JUN-2025 DEFINITION SNAP receptor VAM3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014749 VERSION NP_014749.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183525.1 REFERENCE 1 (residues 1 to 283) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 283) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 283) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 283) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 283) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10881. Method: conceptual translation. FEATURES Location/Qualifiers source 1..283 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..283 /product="SNAP receptor VAM3" /calculated_mol_wt="32366" Region 1..267 /region_name="COG5325" /note="t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]" /db_xref="CDD:227635" CDS 1..283 /gene="VAM3" /locus_tag="YOR106W" /gene_synonym="PTH1" /coded_by="NM_001183525.1:1..852" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:9202390]" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:17054985]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9425154]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:9685264]" /experiment="EXISTENCE:genetic interaction:GO:0048278 vesicle docking [PMID:9245783]" /experiment="EXISTENCE:genetic interaction:GO:0051469 vesicle fusion with vacuole [PMID:9245783]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0097352 autophagosome maturation [PMID:9202390]" /note="Vacuolar membrane protein and Qa class t-SNARE; syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region" /db_xref="GeneID:854273" /db_xref="SGD:S000005632" ORIGIN 1 msffdieaqs skgnsqqepq fstnqktkel snlietfaeq srvlekectk igskrdskel 61 rykietelip nctsvrdkie snilihqngk lsadfknlkt kyqslqqsyn qrkslfplkt 121 pispgtsker kdihprteav rqdpessyis ikvneqspll hnegqhqlql qeeqeqqqqg 181 lsqeeldfqt iihqersqqi grihtavqev naifhqlgsl vkeqgeqvtt idenishlhd 241 nmqnankqlt radqhqrdrn kcgkvtliii ivvcmvvlla vls // LOCUS NP_014750 309 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein RGS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014750 VERSION NP_014750.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183526.3 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10882. On Jul 30, 2012 this sequence version replaced NP_014750.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..309 /product="GTPase-activating protein RGS2" /calculated_mol_wt="34969" Region 42..154 /region_name="RGS" /note="Regulator of G protein signaling (RGS) domain superfamily; cd07440" /db_xref="CDD:188659" CDS 1..309 /gene="RGS2" /locus_tag="YOR107W" /coded_by="NM_001183526.3:1..930" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:10523302]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway [PMID:10523302]" /note="Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p" /db_xref="GeneID:854274" /db_xref="SGD:S000005633" ORIGIN 1 masvpslcdi lipleknsrs dgdaessntv liqlrkghhe rmrspytiqk fykflkrahc 61 eenleffeka hqflqlkqnr siseekllev wnkslyikyi avdspkecnf sqdtreifek 121 cfannevpad vdvlcaishv mgllmdgyhr fvssvnekky satyahndsa teqdlknest 181 tsfsslgved isedrnsylk kpdinglsti iqetsanttn esqcsdrtsr psesssslnt 241 tsstykntst rnlqkpqntg ilnsgkgllq klnfvkkrks fkqpsgvics hynsnvqnrl 301 kgqnshqqr // LOCUS NP_014751 604 aa linear PLN 30-JUN-2025 DEFINITION 2-isopropylmalate synthase LEU9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014751 VERSION NP_014751.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183527.1 REFERENCE 1 (residues 1 to 604) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 604) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 604) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 604) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10883. Method: conceptual translation. FEATURES Location/Qualifiers source 1..604 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..604 /product="2-isopropylmalate synthase LEU9" /EC_number="2.3.3.13" /calculated_mol_wt="67069" Region 34..596 /region_name="leuA_yeast" /note="2-isopropylmalate synthase, yeast type; TIGR00970" /db_xref="CDD:273371" CDS 1..604 /gene="LEU9" /locus_tag="YOR108W" /coded_by="NM_001183527.1:1..1815" /experiment="EXISTENCE:direct assay:GO:0003852 2-isopropylmalate synthase activity [PMID:11158296|PMID:25841022]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:11158296|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0003852 2-isopropylmalate synthase activity [PMID:10790691]" /experiment="EXISTENCE:genetic interaction:GO:0009098 L-leucine biosynthetic process [PMID:10790691]" /experiment="EXISTENCE:mutant phenotype:GO:0009098 L-leucine biosynthetic process [PMID:25841022]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:25841022]" /note="Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication" /db_xref="GeneID:854275" /db_xref="SGD:S000005634" ORIGIN 1 mvkhsfiala ehasklrrsi ppvkltyknm lrdpsvkyra fappkmvkri wpdktiqkap 61 rwlstdlrdg nqslpdpmsv aqkkeyfhkl inigfkeiev sfpsasqtdf dftryavena 121 pddvgiqclv qsrehlikrt vealtgakra tihtylatsd mfreivfnms reeaiskave 181 atklvrkltk ddpsqqatrw syefspecfs dtpgefavei ceavkkawep teenpiifnl 241 patvevaspn vyadqieyfs thiterekvc isthchndrg cgvaatelgm lagadrvegc 301 lfgngertgn vdlvtvamnm ytqgvspnld fsdltsisei vhrcnkipip prapyggelv 361 vsafsgshqd aikkgfaiqn kkqaqgetrw ripylpldpk digrdyeavi rvnsqsgkgg 421 aawvimrslg ldvprpmqvd fsntlqknad algrelksee itklfketyn ynnnehiyvt 481 llnyevkkln perralvgqv eindkvvnie gygngpissl vdalsnllnv klsvqnyseh 541 slgsgsatqa asfinlsyik dinnhatsnm wgvgvsedtg dasikavfat vnniihsgdv 601 llae // LOCUS NP_014752 1107 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014752 VERSION NP_014752.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183528.3 REFERENCE 1 (residues 1 to 1107) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1107) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1107) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1107) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10884. On Jul 30, 2012 this sequence version replaced NP_014752.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1107 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1107 /product="phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53" /EC_number="3.1.3.36" /calculated_mol_wt="124446" Region 1..603 /region_name="COG5329" /note="Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]" /db_xref="CDD:227637" Region 566..858 /region_name="INPP5c_ScInp51p-like" /note="Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of Saccharomyces cerevisiae Inp51p, Inp52p, and Inp53p, and related proteins; cd09090" /db_xref="CDD:197324" Site order(574,576,606,610,705,708..709,746,748,750,803..804, 819,825,848..849) /site_type="active" /note="putative active site [active]" /db_xref="CDD:197324" Site order(574,606,705,746,748,825,848..849) /site_type="active" /note="putative catalytic site [active]" /db_xref="CDD:197324" Site order(576,606,848) /site_type="other" /note="Mg binding site [ion binding]" /db_xref="CDD:197324" Site order(705,748,849) /site_type="other" /note="putative phosphate binding site [ion binding]" /db_xref="CDD:197324" Site order(708..709,750,803..804,819,848) /site_type="other" /note="PI/IP binding site [chemical binding]" /db_xref="CDD:197324" CDS 1..1107 /gene="INP53" /locus_tag="YOR109W" /gene_synonym="SJL3; SOP2" /coded_by="NM_001183528.3:1..3324" /experiment="EXISTENCE:direct assay:GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11094088]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9560389]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:11094088]" /experiment="EXISTENCE:direct assay:GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity [PMID:10224048]" /experiment="EXISTENCE:direct assay:GO:0046856 phosphatidylinositol dephosphorylation [PMID:10224048]" /experiment="EXISTENCE:mutant phenotype:GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity [PMID:9438131]" /experiment="EXISTENCE:mutant phenotype:GO:0046856 phosphatidylinositol dephosphorylation [PMID:9438131]" /note="Polyphosphatidylinositol phosphatase; dephosphorylates multiple phosphatidylinositol phosphates; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains; INP53 has a paralog, INP52, that arose from the whole genome duplication" /db_xref="GeneID:854276" /db_xref="SGD:S000005635" ORIGIN 1 miifvseepe rrlaivsnly alvlkpvgkk psdkplcaie llqkndlkky gfkrltshei 61 fgviglievn gllfvgaitg kskvaqpcpg etvnkifavd ffclndnswd fieidssgyp 121 vlpetastey qdalpkhpcy elkkllsngs fyyssdfdlt stlqhrgygq hslstdtyee 181 eymwnsflmq emityrdhld tnlkqildde gflttvirgf aetfvsyvkk lkvaltiisk 241 qswkragtrf nargvddean vanfvetefi myssqycyaf tqirgsipvf weqgtslinp 301 rvqitrsfea tqpvfdkhim ksvekygpvh vvnllstkss eielskryke hlthskklnf 361 nkdifltefd fhketsqegf sgvrklipli ldsllssgyy sydvrekkni seqhgifrtn 421 cldcldrtnl aqqiislaaf rtfledfrli ssnsfidddd fvskhntlwa dhgdqisqiy 481 tgtnalkssf srkgkmslag alsdatksvs riyinnfmdk ekqqnidtll grlpyqkavq 541 lydpvneyvs tklqsmsdkf tstsninlli gsfnvngatk kvdlskwlfp igekfkpdiv 601 vlglqeviel sagsilnady skssfwenlv gdclnqyddk ylllrveqmt sllilffvka 661 dkakyvkqve gatkktgfrg magnkgavsi rfeygatsfc fvnshlaaga tnveerrsdy 721 esivrgitft rtkmiphhds ifwlgdmnyr inlpnedvrr ellnqeegyi dkllhfdqlt 781 lginsgsvfe gfkeptlkfr ptykydpgtg tydssekert pswtdriiyk genllplsys 841 dapimisdhr pvyaayraki tfvddkerls lkkrlfteyk qehpeepgsl isdllsldld 901 nkstdgfkss sesslldidp imaqptassv assspvssas aslqpvrtqn ssqsrtpikk 961 pvlrpppppa hksvsapaps tskeksptpq tstaslssvt kniqenkpla qnrripppgf 1021 sqniltpkst snlaspmssk vdlynsases trsaqdarqq tptafaasrd vngqpeallg 1081 denpiepeek aklnhmtlds wqpltpk // LOCUS NP_014753 435 aa linear PLN 30-JUN-2025 DEFINITION transcription factor TFIIIC subunit TFC7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014753 VERSION NP_014753.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183529.1 REFERENCE 1 (residues 1 to 435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 435) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10885. Method: conceptual translation. FEATURES Location/Qualifiers source 1..435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..435 /product="transcription factor TFIIIC subunit TFC7" /calculated_mol_wt="49015" Region 6..188 /region_name="His_Phos_1" /note="Histidine phosphatase superfamily (branch 1); pfam00300" /db_xref="CDD:459751" Region 289..365 /region_name="TFIIIC_sub6" /note="TFIIIC subunit triple barrel domain; pfam10419" /db_xref="CDD:463085" CDS 1..435 /gene="TFC7" /locus_tag="YOR110W" /coded_by="NM_001183529.1:1..1308" /experiment="EXISTENCE:direct assay:GO:0000127 transcription factor TFIIIC complex [PMID:2002052|PMID:9584160|PMID:1474578]" /experiment="EXISTENCE:direct assay:GO:0000995 RNA polymerase III general transcription initiation factor activity [PMID:9584160]" /experiment="EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2404611|PMID:2649882]" /experiment="EXISTENCE:direct assay:GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding [PMID:2404611]" /experiment="EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:8464480|PMID:2183033|PMID:9584160|PMID:3633923]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2002052]" /experiment="EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:23569204]" /experiment="EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2183033]" /experiment="EXISTENCE:mutant phenotype:GO:0000995 RNA polymerase III general transcription initiation factor activity [PMID:9584160]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:9584160]" /note="RNA pol III transcription initiation factor complex (TFIIIC) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a paralog, YNL108C, that arose from the whole genome duplication" /db_xref="GeneID:854277" /db_xref="SGD:S000005636" ORIGIN 1 mvvntiyiar hgyrsnwlpe gpypdpltgi dsdvplaehg vqqakelahy llsldnqpea 61 afaspfyrcl etvqpiakll eipvylergi gewyrpdrkp vipvpagyei lskffpgvis 121 qewdstltpn ekgeteqemy mrfkkfwplf iervekeypn vecillvtha askialgmsl 181 lgydnprmsl nengdkirsg scsldkyeil kksydtidet ddqtsftyip fsdrkwvltm 241 ngnteflssg eemnwnfdcv aeagsdadik krqmtkktss pipeaddqte vetvyisvdi 301 psgnykerte iaksailqys gletdaplfr ignrlyegsw erlvgtelaf pnaahvhkkt 361 agllspteen ettnagqskg sstandpniq iqeedvglpd stntsrdhtg dkeevqseki 421 yrikerivls nvrpm // LOCUS NP_014754 232 aa linear PLN 30-JUN-2025 DEFINITION nucleotide diphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014754 VERSION NP_014754.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183530.3 REFERENCE 1 (residues 1 to 232) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 232) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 232) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 232) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 232) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10886. On Jul 30, 2012 this sequence version replaced NP_014754.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..232 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..232 /product="nucleotide diphosphatase" /EC_number="3.6.1.9" /calculated_mol_wt="26346" Region 17..226 /region_name="maf" /note="MAF protein; TIGR00172" /db_xref="CDD:129276" Site order(25,30,52,74,103,116) /site_type="active" /db_xref="CDD:238310" Site order(68,152,157..161) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238310" CDS 1..232 /locus_tag="YOR111W" /coded_by="NM_001183530.3:1..699" /note="hypothetical protein" /db_xref="GeneID:854278" /db_xref="SGD:S000005637" ORIGIN 1 msgnsqlppd vigficskyd iilastsprr yeilhdimgi tdlktmvstf eenldkmnys 61 tdpigyvcdt swhkaqniie iltdyedenp neidkpklii cadtiiidks griyekpktk 121 evqkkflmkf cyeddepvnv vtavtlikwy grenfelvpf rdetkvyfdn kiplrileey 181 vesgdglevg ggfkiqgqga iliekiegdy ynvvglplnk tfkglyaean si // LOCUS NP_014755 761 aa linear PLN 30-JUN-2025 DEFINITION COPI-interacting protein CEX1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014755 VERSION NP_014755.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183531.1 REFERENCE 1 (residues 1 to 761) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 761) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 761) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 761) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 761) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10887. Method: conceptual translation. FEATURES Location/Qualifiers source 1..761 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..761 /product="COPI-interacting protein CEX1" /calculated_mol_wt="84638" Region 29..257 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Region 342..371 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 356..>491 /region_name="YCG1" /note="Chromosome condensation complex Condensin, subunit G [Chromatin structure and dynamics / Cell division and chromosome partitioning]; COG5218" /db_xref="CDD:227543" Site order(363..364,367,370..371,402..403,406,409..410,413, 441..442,445,448..449,452,482..483,486,489..490) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 385..413 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 423..453 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 462..490 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" CDS 1..761 /gene="CEX1" /locus_tag="YOR112W" /coded_by="NM_001183531.1:1..2286" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:17203074]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:17203074]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:17203074]" /experiment="EXISTENCE:genetic interaction:GO:0006409 tRNA export from nucleus [PMID:17203074|PMID:22008473]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:17203074]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:33753324]" /experiment="EXISTENCE:physical interaction:GO:0005643 nuclear pore [PMID:17203074]" /experiment="EXISTENCE:physical interaction:GO:0006409 tRNA export from nucleus [PMID:17203074]" /note="Component of COPI-mediated trafficking and tRNA nuclear export; enables Rna1p to access and activate Gsp1p-GTP bound to the export receptor tRNA complex during aminoacylation-dependent tRNA export; copurifies with tRNA export receptors; interacts with COPI coat proteins and regulates Golgi-to-ER trafficking; membrane fraction associated; mutations in members of the homologous human SCY1-like (SCYL) family of pseudokinases are linked to peripheral neuropathy, cerebellar atrophy, ataxia and ALS" /db_xref="GeneID:854279" /db_xref="SGD:S000005638" ORIGIN 1 mnfssifksi snfqfpytie etaitetalw qcfdgtrkad slpvtvfkak rspeneslil 61 navhkskilk ipglctvlet fdsdpqstfi vtervvpfpw dnlgslsqnk fgvelgisql 121 latlgflknf vlgtlskdsv finikgewvl fglelcsske glsafefasr arsyyniigs 181 qlpcedpnti dsmglgllik slmapsclpk dwivnvnmis dgkitienfr krlentetwr 241 snplinfyqe lrelhikdpq gklvvmsnle nlylesreif rnltpgmien fiipelceii 301 kllmtqsiss aaspigmnfn ashklvpfla ivldltsetn tfpvgfndli tqsfklpdrq 361 vrfllliylp kligplskse issriyphfi qgltdsdatl rlqtlktipc ivsclterql 421 nnellrflak tqvdsdveir twtviiiski stilstsvgn rsnilataft kslkdpqvkp 481 rlaalyglek sielfdvnti ankiltviap glldkspivr grakilfeey leklekeaql 541 iqtndstads edvkdidfen ygcdeedmnk ednllaaqfl nnlrlnspsa ttpsnitese 601 idsaqdgsgw ddlsdtdgfi tngttesfde ttnpvttast pklfgkpiki nkswndelnd 661 dgwiqdesgp skvpqkhtrp qnstlaksia pssrlsikkk kttilaprni asnstvttks 721 slsnktarsk pissirgsvt kkgnvdgwdd dgdsdswdtn w // LOCUS NP_014756 914 aa linear PLN 30-JUN-2025 DEFINITION Azf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014756 VERSION NP_014756.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183532.3 REFERENCE 1 (residues 1 to 914) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 914) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 914) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 914) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 914) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10888. On Jul 30, 2012 this sequence version replaced NP_014756.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..914 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..914 /product="Azf1p" /calculated_mol_wt="101039" Region 342..768 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 595..615 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(600,602,604,606..607,610..611,614,628,630,634..635, 638..639,642,656,658,660,662..663,666..667,670) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 623..643 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 651..671 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 679..702 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..914 /gene="AZF1" /locus_tag="YOR113W" /coded_by="NM_001183532.3:1..2745" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:16467472|PMID:11839825]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11839825]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16467472|PMID:9799362|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11839825]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:16467472]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:11839825]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11839825]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:16467472]" /experiment="EXISTENCE:mutant phenotype:GO:0071322 cellular response to carbohydrate stimulus [PMID:11839825|PMID:16467472]" /note="Zinc-finger transcription factor; involved in the diauxic shift; activates transcription of genes involved in carbon metabolism and energy production on glucose, while it activates transcription of genes involved in cell wall organization and biogenesis on glycerol-lactate; may also function as a co-repressor; capable of forming the prion [AZF1+]; relocalizes to the cytosol in response to hypoxia; contains polyglutamine and polyasparagine domains" /db_xref="GeneID:854280" /db_xref="SGD:S000005639" ORIGIN 1 mppptaqfmg ptqagqnesq nqssgeageq nqehgqgptp ilnqsqpass qpqhqqqrne 61 sisyytnfnq prystdasin sflnisdnvp vtstggpssg gaysnlprls tssthqppdl 121 sqigrgfsiv nnlfpqqqql qnqhrqqqqq qqqqshqqpp fktpsfstgl tgsssqyqfl 181 prndntsqpp skrnsvylgp ndgpdfeffs mqqsqqpqfq pssrresnsm rppllipaat 241 tksqsngtnn sgnmntnady esffntgtnn snsnqnpyfl ssrnnslkfn pedfdfqfkr 301 rnsfvrgtld hssqnafipe srlnslsvnn kangdpvadn vtnnmkgksn evdnddgnds 361 snnnnnnnnn nnnennndnn ndnndnsins atstnipnqe dhslastdtt snsrkdlkei 421 eqrlrkhlnd ednyssaisr pldkndvieg seglnkhide sgmqpniikk rkkddstvyv 481 knemprtdpp mskdnstsae gaamanfsgk eppipdissv sddatnliga tkvdqlmlii 541 qarkkgftek vnttqdgdll fnqtmdilpp kselvggvek pkgtqntrav kkhecpychr 601 lfsqathlev hvrshigykp fvcdycgkrf tqggnlrthe rlhtgekpys cdicdkkfsr 661 kgnlaahlvt hqklkpfvck lencnktftq lgnmkahqnr fhketlnalt aklaemnpse 721 nipleerqll eyfasiykns nrgikgrgkg vgtkkstiss penhpastil npntnannai 781 andsenngnp egnidsssns npgshsmisp tqkdmgtlqs qfiqnnfnns vnssnpsnqp 841 iinynyttlp hsrlgsssss ntnnnnsnfs vgaapgvlma pttnndfsfn ldqsndners 901 qqeqvrfkni nyks // LOCUS NP_014757 294 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial HMG-box protein CIM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014757 VERSION NP_014757.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183533.1 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10889. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..294 /product="mitochondrial HMG-box protein CIM1" /calculated_mol_wt="34844" CDS 1..294 /gene="CIM1" /locus_tag="YOR114W" /gene_synonym="DPI34" /coded_by="NM_001183533.1:1..885" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:37850632]" /experiment="EXISTENCE:genetic interaction:GO:0000002 mitochondrial genome maintenance [PMID:37850632]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:37850632]" /note="Mitochondrial HMG-box protein; limits the copy number of mitochondrial DNA (mtDNA), antagonizing HMG-box containing protein Abf2p, a mtDNA packaging factor; localizes to the mitochondrial matrix; contains two HMG-boxes similar to Abf2p; null mutant is viable" /db_xref="GeneID:854281" /db_xref="SGD:S000005640" ORIGIN 1 mkatlllkaq lspvsyttkk sfqrqlnrtp ytafqyffql evqklhnvsk yediinhvrg 61 nsnfkrfarn ewdsmsltkk rlyyasfcqs mdidilnvsk ielakrleip ipamseyllf 121 rnkfkvkfds hcsslerkdr ksvprpsitr kvatteicsk srsntpvgki nprkrlvalk 181 risrsentak nhsheaqnyl ydymkrfqqm ckecryawne evdydqklei rkklqvwrak 241 feemmdneiq ilqknmdims kfglrsesyl taanhdtntq pnnilpmtyl lkkk // LOCUS NP_014758 268 aa linear PLN 30-JUN-2025 DEFINITION Trs33p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014758 VERSION NP_014758.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183534.3 REFERENCE 1 (residues 1 to 268) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 268) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 268) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 268) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10890. On Jul 30, 2012 this sequence version replaced NP_014758.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..268 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..268 /product="Trs33p" /calculated_mol_wt="30618" Region 41..265 /region_name="TRAPPC6A_Trs33" /note="Trs33 subunit of the TRAPP complex; cd14944" /db_xref="CDD:271347" Site order(43,46,50,195..196,210,214) /site_type="other" /note="synbindin interface [polypeptide binding]" /db_xref="CDD:271347" Site order(44..45,47..49,51..52,55,122,126,129..130,133..134, 137,167,170,190,217) /site_type="other" /note="BET3 interface [polypeptide binding]" /db_xref="CDD:271347" CDS 1..268 /gene="TRS33" /locus_tag="YOR115C" /coded_by="NM_001183534.3:1..807" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:27672095]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:19843283]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:19843283]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990070 TRAPPI protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990071 TRAPPII protein complex [PMID:11239471]" /experiment="EXISTENCE:direct assay:GO:1990072 TRAPPIII protein complex [PMID:20375281]" /experiment="EXISTENCE:genetic interaction:GO:0000407 phagophore assembly site [PMID:27672095]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:9564032]" /experiment="EXISTENCE:genetic interaction:GO:0016239 positive regulation of macroautophagy [PMID:27672095]" /experiment="EXISTENCE:genetic interaction:GO:0031503 protein-containing complex localization [PMID:27672095]" /experiment="EXISTENCE:genetic interaction:GO:0034497 protein localization to phagophore assembly site [PMID:27672095]" /experiment="EXISTENCE:genetic interaction:GO:0065003 protein-containing complex assembly [PMID:19843283]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:27672095]" /note="Core component of TRAPP complexes I, II and IV; transport protein particle (TRAPP) complexes are related multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII, and IV); proposed subunit of a novel complex, TRAPPIV, that may function redundantly with TRAPPIII as a GEF that activates Ypt1 during autophagy" /db_xref="GeneID:854282" /db_xref="SGD:S000005641" ORIGIN 1 mssthsnnvg hpqsspqgpl teqqraqqqy qifenslpkv sqsvyqmlln emvplamgie 61 rqisgdviss dsnvtsengn innmikrlki eehhtvdiir shnlihelyk adeeekekvl 121 arlrnigfqi glklsellif snnpnlkfke mdlllimkfi crdvwkqifg kqidnlktnh 181 rgtfylldyd yrpiqsfsle edakneelkm iepfleipvg iirgvlsslg ysseevicla 241 sfidrptdrp ktafpkgvsf hvqvtmpq // LOCUS NP_014759 1460 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase III core subunit RPO31 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014759 VERSION NP_014759.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183535.1 REFERENCE 1 (residues 1 to 1460) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1460) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1460) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1460) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10891. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1460 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1460 /product="DNA-directed RNA polymerase III core subunit RPO31" /EC_number="2.7.7.6" /calculated_mol_wt="162171" Region 21..905 /region_name="RNAP_III_RPC1_N" /note="Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain; cd02583" /db_xref="CDD:259847" Site order(67,70,77,80) /site_type="other" /note="Zn-binding [ion binding]" /db_xref="CDD:259847" Site order(360,365,372,378) /site_type="active" /note="putative active site region [active]" /db_xref="CDD:259847" Region 789..>1114 /region_name="rpoC2" /note="DNA-directed RNA polymerase subunit beta'; Provisional; PRK02597" /db_xref="CDD:235052" Region 1077..1428 /region_name="RNAP_III_Rpc1_C" /note="Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain; cd02736" /db_xref="CDD:132723" Site order(1079..1080,1084,1087,1425,1428) /site_type="other" /note="Rpb1 (Rpc1) - Rpb6 interaction site [polypeptide binding]" /db_xref="CDD:132723" Site order(1084..1145,1150..1164,1274..1285,1291..1344, 1347..1379,1382) /site_type="active" /note="cleft [active]" /db_xref="CDD:132723" Site order(1088,1091,1397,1407..1409,1415..1416,1418,1420,1425) /site_type="other" /note="Rpb1 (Rpc1) - Rpb2 (Rpc2) interaction site [polypeptide binding]" /db_xref="CDD:132723" Site order(1133,1373,1390..1391,1394) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:132723" Site order(1305,1311..1312,1314,1324..1330,1332,1352,1363..1364, 1366) /site_type="other" /note="Rpb1 (Rpc1) - Rpb5 interaction site [polypeptide binding]" /db_xref="CDD:132723" Site 1382..1423 /site_type="active" /note="clamp [active]" /db_xref="CDD:132723" CDS 1..1460 /gene="RPO31" /locus_tag="YOR116C" /gene_synonym="RPC1; RPC160" /coded_by="NM_001183535.1:1..4383" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /note="RNA polymerase III largest subunit C160; part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21" /db_xref="GeneID:854283" /db_xref="SGD:S000005642" ORIGIN 1 mkevvvsetp krikglefsa lsaadivaqs evevstrdlf dlekdrapka ngaldpkmgv 61 sssslecatc hgnlaschgh fghlklalpv fhigyfkati qilqgicknc saillsetdk 121 rqflhelrrp gvdnlrrmgi lkkildqckk qrrclhcgal ngvvkkaaag agsaalkiih 181 dtfrwvgkks apekdiwvge wkevlahnpe leryvkrcmd dlnplktlnl fkqiksadce 241 llgidatvps grpetyiwry lpappvcirp svmmqdspas neddltvklt eivwtsslik 301 agldkgisin nmmehwdylq ltvamyinsd svnpamlpgs sngggkvkpi rgfcqrlkgk 361 qgrfrgnlsg krvdfsgrtv ispdpnlsid evavpdrvak vltypekvtr ynrhklqeli 421 vngpnvhpga nyllkrneda rrnlrygdrm klaknlqigd vverhledgd vvlfnrqpsl 481 hrlsilshya kirpwrtfrl necvctpyna dfdgdemnlh vpqteearae ainlmgvknn 541 lltpksgepi iaatqdfitg sylishkdsf ydratltqll smmsdgiehf dipppaimkp 601 yylwtgkqvf sllikpnhns pvvinldakn kvfvppksks lpnemsqndg fviirgsqil 661 sgvmdksvlg dgkkhsvfyt ilrdygpqea anamnrmakl carflgnrgf sigindvtpa 721 ddlkqkkeel veiayhkcde litlfnkgel etqpgcneeq tleakiggll skvreevgdv 781 cineldnwna plimatcgsk gstlnvsqmv avvgqqiisg nrvpdgfqdr slphfpknsk 841 tpqskgfvrn sffsglsppe flfhaisgre glvdtavkta etgymsrrlm ksledlscqy 901 dntvrtsang ivqftyggdg ldplemegna qpvnfnrswd haynitfnnq dkgllpyaim 961 etaneilgpl eerlvrydns gclvkredln kaeyvdqyda erdfyhslre yingkatala 1021 nlrksrgmlg lleppakelq gidpdetvpd nvktsvsqly riseksvrkf leialfkyrk 1081 arlepgtaig aigaqsigep gtqmtlktfh fagvasmnvt lgvprikeii naskvistpi 1141 inavlvndnd eraarvvkgr vektllsdva fyvqdvykdn lsfiqvridl gtidklqlel 1201 tiediavait rasklkiqas dvniigkdri ainvfpegyk aksistsake psendvfyrm 1261 qqlrralpdv vvkglpdisr avinirddgk rellvegygl rdvmctdgvi gsrtttnhvl 1321 evfsvlgiea arysiirein ytmsnhgmsv dprhiqllgd vmtykgevlg itrfglskmr 1381 dsvlqlasfe kttdhlfdaa fymkkdaveg vseciilgqt msigtgsfkv vkgtnisekd 1441 lvpkrclfes lsneaalkan // LOCUS NP_014760 434 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle base subunit RPT5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014760 VERSION NP_014760.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183536.3 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10892. On Jul 30, 2012 this sequence version replaced NP_014760.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..434 /product="proteasome regulatory particle base subunit RPT5" /calculated_mol_wt="48125" Region 15..429 /region_name="PRK03992" /note="proteasome-activating nucleotidase; Provisional" /db_xref="CDD:179699" CDS 1..434 /gene="RPT5" /locus_tag="YOR117W" /gene_synonym="YTA1" /coded_by="NM_001183536.3:1..1305" /experiment="EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:11742986|PMID:9741626]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:9724628]" /experiment="EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:19843524]" /experiment="EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19412160]" /note="ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1" /db_xref="GeneID:854284" /db_xref="SGD:S000005643" ORIGIN 1 matleeldaq tlpgddeldq eilnlstqel qtraklldne irifrselqr lshennvmle 61 kikdnkekik nnrqlpylva nvvevmdmne iedkensest tqggnvnldn tavgkaavvk 121 tssrqtvflp mvglvdpdkl kpndlvgvnk dsylildtlp sefdsrvkam evdekptety 181 sdvggldkqi eelveaivlp mkradkfkdm girapkgalm ygppgtgktl laracaaqtn 241 atflklaapq lvqmyigega klvrdafala kekaptiifi deldaigtkr fdseksgdre 301 vqrtmlelln qldgfssddr vkvlaatnrv dvldpallrs grldrkiefp lpsedsraqi 361 lqihsrkmtt dddinwqela rstdefngaq lkavtveagm ialrngqssv khedfvegis 421 evqarksksv sfya // LOCUS NP_014761 567 aa linear PLN 30-JUN-2025 DEFINITION Rtc5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014761 VERSION NP_014761.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183537.1 REFERENCE 1 (residues 1 to 567) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 567) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 567) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 567) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10893. Method: conceptual translation. FEATURES Location/Qualifiers source 1..567 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..567 /product="Rtc5p" /calculated_mol_wt="64164" Region 355..515 /region_name="TLD" /note="pfam07534" /db_xref="CDD:429519" CDS 1..567 /gene="RTC5" /locus_tag="YOR118W" /coded_by="NM_001183537.1:1..1704" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:38589611]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0032984 protein-containing complex disassembly [PMID:38589611]" /note="Protein that regulates the vacuolar V-ATPase; regulates the assembly state of the V-ATPase holoenzyme, promoting complex disassembly, and counteracting the function of the RAVE complex; interacts with V-ATPase subunits; vacuolar membrane localization requires N-myristoylation and an assembled V-ATPase; GFP-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity; member of a conserved family of TLDc domain proteins found in eukaryotes" /db_xref="GeneID:854285" /db_xref="SGD:S000005644" ORIGIN 1 mgqsssisss neegsshskk ftnskdilay fnnkaqqqvt ipelvsfkgn lqiedlntpi 61 shkalcnsly fpqnhamivg ivtnmlrvls nfplmkssye pitgygllkc illlnrarca 121 kflktksydq lkllfislsl qktdkeelse esendgnkel tikqiitgfd dvdtemlcip 181 adfmlqfltw lliltvdcpt tnskldntet hdqwgnfkvs alnllrtmnp dvvgdieshs 241 itfqqfstai rtvmpnllkp lenlmehffy lqhdlvdhdt nlssiqdskv mtpallaqls 301 tglpkelfih klqslyigrk sgfsmrslqa kvfkwmapsi lvvsgmritn seeyaaeknp 361 ryrhfleefp klkesdqmmd ashlnkrktt favyiddpwk vtnkdyfgdl ntriieispr 421 qdiykvnqkg tiyfntiggg igigdkqpli kpaskryipg nvsltfdstl efavfrntgy 481 ggsldpglls merkeenspy elhfliqdve vwgcggekel eeqikqlewe eaeskrrqqi 541 nlrslgedra llemaglvgq hqgggsm // LOCUS NP_014762 484 aa linear PLN 30-JUN-2025 DEFINITION protein kinase RIO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014762 VERSION NP_014762.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183538.3 REFERENCE 1 (residues 1 to 484) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 484) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 484) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 484) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10894. On Jul 30, 2012 this sequence version replaced NP_014762.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..484 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..484 /product="protein kinase RIO1" /EC_number="2.7.11.1" /calculated_mol_wt="55991" Region 78..291 /region_name="RIO1_euk" /note="Catalytic domain of the atypical protein serine kinase, Eukaryotic RIO1 kinase; cd05147" /db_xref="CDD:270698" Site order(82,87..88,90,123,125,183,195..198,208,249,251, 260..261) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270698" CDS 1..484 /gene="RIO1" /locus_tag="YOR119C" /gene_synonym="RRP10" /coded_by="NM_001183538.3:1..1455" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:30011030]" /experiment="EXISTENCE:direct assay:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11483523|PMID:12612080]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:30011030]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:30011030]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:25851096|PMID:11972772]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:30011030|PMID:12612080]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11483523]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:30011030]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:30011030]" /experiment="EXISTENCE:direct assay:GO:0007096 regulation of exit from mitosis [PMID:11972772]" /experiment="EXISTENCE:direct assay:GO:0030874 nucleolar chromatin [PMID:25851096]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:37263996]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:25851096]" /experiment="EXISTENCE:mutant phenotype:GO:0090234 regulation of kinetochore assembly [PMID:37263996]" /experiment="EXISTENCE:mutant phenotype:GO:2000234 positive regulation of rRNA processing [PMID:25851096]" /note="Serine kinase that controls cell cycle progression; represses rDNA transcription and promotes 20S pre-rRNA maturation; catalytic activity regulates its association with pre-40S particles where it prevents premature entry into translation; downregulates centromeric RNA levels, limits RNAPII accessibility, stimulates cenRNA degradation and promotes timely kinetochore assembly; autophosphorylates and phosphorylates Rpa43p in anaphase to remove Pol I from rDNA" /db_xref="GeneID:854286" /db_xref="SGD:S000005645" ORIGIN 1 msledkfdsl svsqgasdhi nnqllekysh kiktdelsfs raktskdkan ratvenvldp 61 rtmrflksmv trgviadlng clstgkeanv yhafagtgka pvideetgqy evletdgsra 121 eyaikiykts ilvfkdrery vdgefrfrns rsqhnprkmi kiwaekefrn lkriyqsgvi 181 papkpievkn nvlvmeflsr gngfaspklk dypyknrdei fhyyhtmvay mrllyqvcrl 241 vhadlseynt ivhddklymi dvsqsvepeh pmsldflrmd iknvnlyfek mgisifperv 301 ifqfvisetl ekfkgdynni salvayiasn lpiksteqde aedeifrslh lvrslgglee 361 rdfdrytdgk fdllksliah dnernfaase qfefdnadhe cssgteefsd deedgssgse 421 eddeeegeyy dddepkvlkg kkhedkdlkk lrkqeakdak rekrktkvkk hikkklvkkt 481 kskk // LOCUS NP_014763 312 aa linear PLN 30-JUN-2025 DEFINITION glycerol 2-dehydrogenase (NADP(+)) GCY1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014763 VERSION NP_014763.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183539.1 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10895. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..312 /product="glycerol 2-dehydrogenase (NADP(+)) GCY1" /EC_number="1.1.1.156" /calculated_mol_wt="34948" Region 7..296 /region_name="AKR_AKR3A1-2" /note="AKR3A family of aldo-keto reductase (AKR); cd19117" /db_xref="CDD:381343" Site order(26..28,51,55..56,81,112..113,169..170,193,219..225, 235,247,262..267,270,273..274) /site_type="active" /note="putative active site [active]" /db_xref="CDD:381343" Site order(51,56,81,112) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381343" CDS 1..312 /gene="GCY1" /locus_tag="YOR120W" /coded_by="NM_001183539.1:1..939" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0004032 aldose reductase (NADPH) activity [PMID:11306085]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008106 alcohol dehydrogenase (NADP+) activity [PMID:10818358|PMID:17140678]" /experiment="EXISTENCE:direct assay:GO:0016491 oxidoreductase activity [PMID:17962934]" /experiment="EXISTENCE:direct assay:GO:0019568 arabinose catabolic process [PMID:12271459]" /experiment="EXISTENCE:direct assay:GO:0042843 D-xylose catabolic process [PMID:12271459]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:17919749]" /experiment="EXISTENCE:genetic interaction:GO:0061610 glycerol to glycerone phosphate metabolic process [PMID:22979944]" /experiment="EXISTENCE:mutant phenotype:GO:0047953 glycerol 2-dehydrogenase (NADP+) activity [PMID:22979944]" /experiment="EXISTENCE:mutant phenotype:GO:0061610 glycerol to glycerone phosphate metabolic process [PMID:22979944]" /note="Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication" /db_xref="GeneID:854287" /db_xref="SGD:S000005646" ORIGIN 1 mpatlhdstk ilslntgaqi pqiglgtwqs kendaykavl talkdgyrhi dtaaiyrned 61 qvgqaikdsg vpreeifvtt klwctqhhep evaldqslkr lgldyvdlyl mhwparldpa 121 yiknedilsv ptkkdgsrav ditnwnfikt welmqelpkt gktkavgvsn fsinnlkdll 181 asqgnkltpa anqveihpll pqdelinfck skgivveays plgstdapll kepvileiak 241 knnvqpghvv iswhvqrgyv vlpksvnpdr iktnrkiftl stedfeainn iskekgekrv 301 vhpnwspfev fk // LOCUS NP_014765 126 aa linear PLN 30-JUN-2025 DEFINITION profilin [Saccharomyces cerevisiae S288C]. ACCESSION NP_014765 VERSION NP_014765.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183541.3 REFERENCE 1 (residues 1 to 126) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 126) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 126) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 126) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 126) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10896. On Jul 30, 2012 this sequence version replaced NP_014765.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..126 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..126 /product="profilin" /calculated_mol_wt="13546" Region 1..123 /region_name="Profilin" /note="pfam00235" /db_xref="CDD:459724" CDS 1..126 /gene="PFY1" /locus_tag="YOR122C" /gene_synonym="CLS5; PRF1" /coded_by="NM_001183541.3:1..381" /experiment="EXISTENCE:direct assay:GO:0003785 actin monomer binding [PMID:10953013]" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:8247001]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:7592954]" /experiment="EXISTENCE:direct assay:GO:0070064 proline-rich region binding [PMID:8247001|PMID:9698363]" /experiment="EXISTENCE:direct assay:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:12134165]" /experiment="EXISTENCE:direct assay:GO:0140311 protein sequestering activity [PMID:10953013]" /experiment="EXISTENCE:genetic interaction:GO:0046907 intracellular transport [PMID:9720869]" /experiment="EXISTENCE:mutant phenotype:GO:0003785 actin monomer binding [PMID:10953013]" /experiment="EXISTENCE:mutant phenotype:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:8247001]" /experiment="EXISTENCE:mutant phenotype:GO:0070064 proline-rich region binding [PMID:8247001]" /experiment="EXISTENCE:mutant phenotype:GO:0090338 positive regulation of formin-nucleated actin cable assembly [PMID:12134165]" /experiment="EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:12419188]" /note="Profilin; binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress; protein abundance increases in response to DNA replication stress; highly conserved protein; human PFN1 (profilin 1) complements temperature sensitive pfy1 mutants, PFN1 mutations are a rare cause of ALS" /db_xref="GeneID:854289" /db_xref="SGD:S000005648" ORIGIN 1 mswqaytdnl igtgkvdkav iysragdavw atsgglslqp neigeivqgf dnpaglqsng 61 lhiqgqkfml lraddrsiyg rhdaegvvcv rtkqtviiah ypptvqagea tkiveqlady 121 ligvqy // LOCUS NP_014766 464 aa linear PLN 30-JUN-2025 DEFINITION Paf1-complex subunit LEO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014766 VERSION NP_014766.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183542.1 REFERENCE 1 (residues 1 to 464) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 464) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 464) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 464) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10897. Method: conceptual translation. FEATURES Location/Qualifiers source 1..464 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..464 /product="Paf1-complex subunit LEO1" /calculated_mol_wt="53789" Region 169..335 /region_name="Leo1" /note="Leo1-like protein; pfam04004" /db_xref="CDD:461126" CDS 1..464 /gene="LEO1" /locus_tag="YOR123C" /coded_by="NM_001183542.1:1..1395" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:20732871]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15643076]" /experiment="EXISTENCE:direct assay:GO:1990269 RNA polymerase II C-terminal domain phosphoserine binding [PMID:22796944]" /experiment="EXISTENCE:direct assay:GO:2001209 positive regulation of transcription elongation by RNA polymerase I [PMID:20299458]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:11927560]" /experiment="EXISTENCE:genetic interaction:GO:0090262 regulation of transcription-coupled nucleotide-excision repair [PMID:21737840]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:20732871]" /experiment="EXISTENCE:mutant phenotype:GO:0006353 DNA-templated transcription termination [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0009302 sno(s)RNA transcription [PMID:23109428]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:14710186]" /experiment="EXISTENCE:physical interaction:GO:0003712 transcription coregulator activity [PMID:11927560]" /experiment="EXISTENCE:physical interaction:GO:0016593 Cdc73/Paf1 complex [PMID:11884586|PMID:11927560]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11927560]" /note="Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay" /db_xref="GeneID:854290" /db_xref="SGD:S000005649" ORIGIN 1 mssespqdqp qkeqisnnvg vttnstsnee tsrsqddnvk evngnddtke eeqeedaeld 61 dlfgddnddd ddddvkkset eksdsdsded degeninhrs rhreslgldd deaeeqamyt 121 rkfygedann fsdqdettht fkeenvelvr hiipskanvn etashneify aripnfltid 181 pipfdppsfe akvnerasns asredqlddr lidentvrwr ysrdkdqhvf kesntqivqw 241 sdgtyslkvg eectdilvnd tsntfltvsh dqqeliqcye ggeikktlmf iptstnskih 301 qklskavirr nqrqskgpgt yivsmdpeve kkelerkqsq ilrdrrrrql kekekqespd 361 aafetgfrkq nspttygasr rneyeeddfl vdddeeeeaa fddeeddnee eeeeedadee 421 nasrlrnlkr egaamyreee eeekdrsetk rrrvaviedd eded // LOCUS NP_014767 1272 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-specific protease UBP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014767 VERSION NP_014767.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183543.3 REFERENCE 1 (residues 1 to 1272) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1272) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1272) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1272) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1272) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10898. On Jul 30, 2012 this sequence version replaced NP_014767.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1272 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1272 /product="ubiquitin-specific protease UBP2" /EC_number="3.4.19.12" /calculated_mol_wt="146224" Region 585..641 /region_name="RPT" /note="A repeated domain in UCH-protein; pfam13446" /db_xref="CDD:463882" Region 658..719 /region_name="RPT" /note="A repeated domain in UCH-protein; pfam13446" /db_xref="CDD:463882" Region 735..1256 /region_name="Peptidase_C19J" /note="A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02666" /db_xref="CDD:239131" Site order(740,745,1209,1228) /site_type="active" /db_xref="CDD:239131" CDS 1..1272 /gene="UBP2" /locus_tag="YOR124C" /coded_by="NM_001183543.3:1..3819" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:1429680]" /experiment="EXISTENCE:direct assay:GO:0004843 cysteine-type deubiquitinase activity [PMID:1429680|PMID:24069405]" /experiment="EXISTENCE:direct assay:GO:0016579 protein deubiquitination [PMID:15933713|PMID:24069405]" /experiment="EXISTENCE:mutant phenotype:GO:0004843 cysteine-type deubiquitinase activity [PMID:24069405]" /experiment="EXISTENCE:mutant phenotype:GO:0010636 positive regulation of mitochondrial fusion [PMID:23317502]" /experiment="EXISTENCE:mutant phenotype:GO:0010992 ubiquitin recycling [PMID:25622294]" /experiment="EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:24069405|PMID:23317502]" /experiment="EXISTENCE:mutant phenotype:GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:19165343]" /experiment="EXISTENCE:mutant phenotype:GO:0070301 cellular response to hydrogen peroxide [PMID:25622294]" /note="Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; controls K63 homeostasis during oxidative stress; deubiquitinates Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity" /db_xref="GeneID:854291" /db_xref="SGD:S000005650" ORIGIN 1 mpnednelqk aienhhnqll nqdkenadrn gsviedlply gtsinqqstp gdvddgkhll 61 ypdiatnlpl ktsdrllddi lcdtiflnst dpkvmqkglq srgilkesml systfrssir 121 pnclgsltdq vvfqtkseyd siscpkynki hvfqavifnp slaeqqistf ddivkipiyh 181 lkvsvkvrqe lerlkkhvgv tqfhsldhlh eydrvdlstf dssdpnlldy giyvsddtnk 241 lilieifkpe fnspeehesf tadaikkryn amcvknesld ksetpsqvdc fytlfkifkg 301 pltrkskaep tktidsgnla lnthlnpewl tskygfqass eideetneif teyvppdmvd 361 yvndletrki resfvrkclq lifwgqlsts llapnsplkn tksvkgmssl qtsfstlpwf 421 hllgesrari llnsneqths pldaephfin lsvshyytdr diirnyesls sldpenigly 481 fdaltyianr kgayqliayc gkqdiigqea lenallmfki npkecnisel neatllsiyk 541 yetsnksqvt snhltnlkna lrllakytks dklkfyvdhe pyralsqayd tlsidesvde 601 diiktaysvk indspglkld cdralytiai skrsldlfnf lteecpqfsn yygpekldyq 661 ealkllqvne nasdetilki fkqkwfdenv yepdqflilr aaltkisier nstlitnfll 721 tgtidpnslp penwptginn igntcylnsl lqyyfsiapl rryvleyqkt venfndhlsn 781 sghirriggr eisrgevers iqfiyqlrnl fyamvhtrer cvtpskelay lafapsnvev 841 efevegnkvv dqtgvlsdsk kettddaftt kikdtslidl emedglngdv gtdanrkkne 901 sndaevsene dttgltsptr vakissdqle nalemgrqqd vtecignvlf qiesgsepir 961 ydedneqydl vkqlfygttk qsivplsatn kvrtkverfl sllinigdhp kdiydafdsy 1021 fkdeyltmee ygdvirtvav ttfptilqvq iqrvyydrer lmpfksiepl pfkeviymdr 1081 yadtenplll akkketeemk qklkvmknrq rellsrddsg ltrkdafles ikllesdtik 1141 ktplkieaan dviktlrnnv qnidnelmkl yndinsleek ishqfddfke ygyslfsvfi 1201 hrgeasyghy wiyikdrnrn giwrkyndet isevqeeevf nfnegntatp yflvyvkqgq 1261 egdieplkri lk // LOCUS NP_014768 233 aa linear PLN 30-JUN-2025 DEFINITION putative monooxygenase CAT5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014768 VERSION NP_014768.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183544.1 REFERENCE 1 (residues 1 to 233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 233) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10899. On Oct 2, 2003 this sequence version replaced NP_014768.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..233 /product="putative monooxygenase CAT5" /EC_number="1.14.99.60" /EC_number="1.14.13.253" /calculated_mol_wt="25929" Region 50..230 /region_name="COQ7" /note="Ubiquinone biosynthesis protein COQ7; pfam03232" /db_xref="CDD:460854" CDS 1..233 /gene="CAT5" /locus_tag="YOR125C" /gene_synonym="COQ7" /coded_by="NM_001183544.1:1..702" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:9452453]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:9452453]" /note="Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation" /db_xref="GeneID:854292" /db_xref="SGD:S000005651" ORIGIN 1 mlsrvsvfkp asrgfsvlss lkitehtsak htekpehapk cqnlsdaqaa fldrvirvdq 61 agelgadyiy agqyfvlahr yphlkpvlkh iwdqeihhhn tfnnlqlkrr vrpslltplw 121 kagafamgag talispeaam acteavetvi gghyngqlrn lanqfnlert dgtkgpseei 181 ksltstiqqf rddelehldt aikhdsymav pytvitegik ticrvaiwsa eri // LOCUS NP_014769 238 aa linear PLN 30-JUN-2025 DEFINITION isoamyl acetate-hydrolyzing esterase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014769 VERSION NP_014769.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183545.3 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10900. On Jul 30, 2012 this sequence version replaced NP_014769.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..238 /product="isoamyl acetate-hydrolyzing esterase" /EC_number="3.1.1.112" /calculated_mol_wt="27215" Region 5..207 /region_name="Isoamyl_acetate_hydrolase_like" /note="Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; cd01838" /db_xref="CDD:238876" Site order(12,187,190) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:238876" Site order(12,53,83) /site_type="active" /note="oxyanion hole [active]" /db_xref="CDD:238876" Site order(14,60,87,173,176) /site_type="active" /db_xref="CDD:238876" CDS 1..238 /gene="IAH1" /locus_tag="YOR126C" /coded_by="NM_001183545.3:1..717" /experiment="EXISTENCE:direct assay:GO:0006083 acetate metabolic process [PMID:10855721]" /experiment="EXISTENCE:direct assay:GO:0016788 hydrolase activity, acting on ester bonds [PMID:10855721]" /note="Isoamyl acetate-hydrolyzing esterase; required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing" /db_xref="GeneID:854293" /db_xref="SGD:S000005652" ORIGIN 1 mdyekfllfg dsitefafnt rpiedgkdqy algaalvney trkmdilqrg fkgytsrwal 61 kilpeilkhe snivmatifl gandacsagp qsvplpefid nirqmvslmk syhirpiiig 121 pglvdrekwe kekseeialg yfrtnenfai ysdalaklan eekvpfvaln kafqqeggda 181 wqqlltdglh fsgkgykifh dellkvietf ypqyhpknmq yklkdwrdvl ddgsnims // LOCUS NP_014770 1007 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein RGA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014770 VERSION NP_014770.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183546.1 REFERENCE 1 (residues 1 to 1007) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1007) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1007) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1007) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1007) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1007) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1007) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1007) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1007) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10901. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1007 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1007 /product="GTPase-activating protein RGA1" /calculated_mol_wt="112701" Region 13..67 /region_name="LIM1_Rga" /note="The first LIM domain of Rga GTPase-Activating Proteins; cd09394" /db_xref="CDD:188780" Site order(13,16,34,37,40,43,63,66) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:188780" Region 70..123 /region_name="LIM2_Rga" /note="The second LIM domain of Rga GTPase-Activating Proteins; cd09395" /db_xref="CDD:188781" Site order(70,73,92,95,98,101,119,122) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:188781" Region 803..1002 /region_name="RhoGAP" /note="GTPase-activator protein for Rho-like GTPases; smart00324" /db_xref="CDD:214618" Site order(829,872,876,966,969..970,992) /site_type="other" /note="GTPase interaction site" /db_xref="CDD:238090" Site 829 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:238090" CDS 1..1007 /gene="RGA1" /locus_tag="YOR127W" /gene_synonym="DBM1; THE1" /coded_by="NM_001183546.1:1..3024" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:18166650|PMID:17981141|PMID:7498791|PMID:12455995]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:29074565]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0032177 cellular bud neck split septin rings [PMID:18166650]" /experiment="EXISTENCE:direct assay:GO:0071597 cellular birth scar [PMID:29074565]" /experiment="EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:7498791]" /experiment="EXISTENCE:genetic interaction:GO:0005096 GTPase activator activity [PMID:7498791]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:14517318]" /experiment="EXISTENCE:mutant phenotype:GO:0007015 actin filament organization [PMID:8657111]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:29074565]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:18166650]" /experiment="EXISTENCE:physical interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:7498791]" /experiment="EXISTENCE:physical interaction:GO:0007118 budding cell apical bud growth [PMID:7498791]" /experiment="EXISTENCE:physical interaction:GO:0007119 budding cell isotropic bud growth [PMID:7498791]" /experiment="EXISTENCE:physical interaction:GO:2000222 positive regulation of pseudohyphal growth [PMID:7498791]" /note="GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP); required for proper bud site selection; transiently localizes to previous cell division sites (bud scars; cytokinesis remnants), interacting with Nis1p and Nba1p, to prevent Cdc42p repolarization; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from the bud neck to cytoplasm upon DNA replication stress; contains N-terminal LIM domains and a C-terminal GAP domain" /db_xref="GeneID:854294" /db_xref="SGD:S000005653" ORIGIN 1 mastapneqf pscvrckefi ttghayelgc drwhthcfac ykcekplsce sdflvlgtga 61 licfdcsdsc kncgkkiddl aiilsssnea ycsdcfkcck cgeniadlry aktkrglfcl 121 schekllakr kyyeekkrrl kknlpslptp vidnghtdev sasavlpekt fsrpaslvne 181 ipsgsepskd ietnssdivp hfitgyndsd dnsgsskfgs nvsidvigpe enstehvndd 241 vkeeaeapsa nmslnvatdp tlsckeppsh srnllnktpl rnssgqylak spssyrqgii 301 vndsleesdq idppnnssrn aselltsvlh spvsvnmknp kgsntdifnt geisqmdpsl 361 srkvlnnive etnalqrpvv evvkedrsvp dlagvqqeqa ekysysnnsg kgrkisrsls 421 rrskdlminl ksratgkqds nvklspaskv tsrrsqdlmr dndshtgldt pnsnstsldi 481 lvnnqkslny krftdngtlr vtsgketale eqknhsfksp spidhllqsp atpsnvsmyr 541 tppldssltf drrngssysn qnysipswqk tpktqlensd nfeeqketly ensesrndps 601 ldkeivtaeh ylkqlkinlk elesqreelm keitemksmk ealrrhiesy nseknklyld 661 snelsnnppm ineislgesp pvkhvatass varssvkpkf wkffssakpq teqsiqgvst 721 nntnsivksa pvllsapssg snsgrleisp pvlqnpnefs dvrlvpiend anmgqskdge 781 eyldgsnlyg sslvarcnye nneipmilsv cidfiesdee nmrsegiyrk sgsqlvieei 841 ekqfsawkvq qntetpnilt eqdlnvvtgv lkrylrklpn piftfqiyep lmrlvkskkm 901 menlpfvggk lsleaknsdt ymssksalkn iledlprehy rvlrvlsehi ekvtryshwn 961 rmtlynlalv fapglirdfs gekdiidmke rnyivafifg nykdilt // LOCUS NP_014771 571 aa linear PLN 30-JUN-2025 DEFINITION phosphoribosylaminoimidazole carboxylase ADE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014771 VERSION NP_014771.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183547.3 REFERENCE 1 (residues 1 to 571) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 571) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 571) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 571) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 571) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10902. On Jul 30, 2012 this sequence version replaced NP_014771.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..571 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..571 /product="phosphoribosylaminoimidazole carboxylase ADE2" /EC_number="4.1.1.21" /calculated_mol_wt="62208" Region 6..569 /region_name="PLN02948" /note="phosphoribosylaminoimidazole carboxylase" /db_xref="CDD:178534" CDS 1..571 /gene="ADE2" /locus_tag="YOR128C" /coded_by="NM_001183547.3:1..1716" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004638 phosphoribosylaminoimidazole carboxylase activity [PMID:5767024]" /experiment="EXISTENCE:mutant phenotype:GO:0006144 purine nucleobase metabolic process [PMID:8939809]" /note="Phosphoribosylaminoimidazole carboxylase; catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine" /db_xref="GeneID:854295" /db_xref="SGD:S000005654" ORIGIN 1 mdsrtvgilg ggqlgrmive aanrlniktv ildaenspak qisnsndhvn gsfsnpldie 61 klaekcdvlt ieiehvdvpt lknlqvkhpk lkiypspeti rliqdkyiqk ehlikngiav 121 tqsvpveqas etsllnvgrd lgfpfvlksr tlaydgrgnf vvknkemipe alevlkdrpl 181 yaekwapftk elavmivrsv nglvfsypiv etihkdnicd lcyaparvpd svqlkaklla 241 enaiksfpgc gifgvemfyl etgellinei aprphnsghy tidacvtsqf eahlrsildl 301 pmpknftsfs tittnaimln vlgdkhtkdk eletcerala tpgssvylyg kesrpnrkvg 361 hiniiassma eceqrlnyit grtdipikis vaqkldleam vkplvgiimg sdsdlpvmsa 421 acavlkdfgv pfevtivsah rtphrmsaya isaskrgikt iiagaggaah lpgmvaamtp 481 lpvigvpvkg scldgvdslh sivqmprgvp vatvainnst naallavrll gaydssyttk 541 meqfllkqee evlvkaqkle tvgyeaylen k // LOCUS NP_014772 893 aa linear PLN 30-JUN-2025 DEFINITION Afi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014772 VERSION NP_014772.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183548.1 REFERENCE 1 (residues 1 to 893) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 893) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 893) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 893) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 893) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10903. Method: conceptual translation. FEATURES Location/Qualifiers source 1..893 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..893 /product="Afi1p" /calculated_mol_wt="102120" Region 29..188 /region_name="Afi1" /note="Docking domain of Afi1 for Arf3 in vesicle trafficking; pfam07792" /db_xref="CDD:400236" Region 348..469 /region_name="SPA" /note="Stabilization of polarity axis; cl40631" /db_xref="CDD:454797" CDS 1..893 /gene="AFI1" /locus_tag="YOR129C" /coded_by="NM_001183548.1:1..2682" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18397879]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:18397879]" /experiment="EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:18397879]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:18397879]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:14515169]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:18397879|PMID:14515169]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:18397879]" /note="Arf3p polarization-specific docking factor; required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p" /db_xref="GeneID:854296" /db_xref="SGD:S000005655" ORIGIN 1 mlrrelnnsi snrsienesf pferpnvsyi isaefdnklg pilkhqypkd ipgfnqfshe 61 qrngntsvsm nlaslmipss iernpgkqdi tvftlyynkf tqnyqlfpvp kdprfsfnlh 121 hreqsdgsvt nsiyydaenh qdaknnryti vleddelecq evqnnqkaid neplffinva 181 ntvldttndr gaviksiaig tplktffafk niivlvldly mkaptqaaat dilldcfnml 241 nsidltlind ihskssiqev lhsihdesii tkvfldpdst lkklfcingf dtkdkygniv 301 tfhdqliqyh ftrfqpktlp pfllkiplqf nmirrepiyi endynelvlk fldkfvpyll 361 kagqkvnawk lvinstklsk edlcafilsl anitatyasd pqsyfkgnaa lifpymdisl 421 vdglrayvas nsdfvgcfai igtanpifry qldiwdyyyd vdegvfyenn spekekpdtv 481 aevkigpnpl rkifnrphfs tnavnesqvn lgqklfslli deyhdsdtim svlrrlnvlq 541 lenlldalkr reippnialk deyimfykdf fifpeffdyf tlhsiellsn ldnclfslgn 601 tcqlfsteqi ysqlsqildi vkelfrmvsv srtniekfln aclnyspfki lptaqlhgdn 661 isrwsfesev rqgfdnfnsy mgiekdphgv ivsaidlftq iysfdilaff ltfitkesgq 721 dlpftkslsr rrtyltriaq ssslrqflql strpnirilg gngqgtgnsn ypeftnassv 781 ispklraspl lerraskicy aitkllyrle chpigmallk kylhnqlrea yleskrhfis 841 kkgdstntss tiasssfaga svplssnesg mlnglkqine qqestlettq ked // LOCUS NP_014773 292 aa linear PLN 30-JUN-2025 DEFINITION Ort1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014773 VERSION NP_014773.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183549.4 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10904. On Jul 30, 2012 this sequence version replaced NP_014773.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..292 /product="Ort1p" /calculated_mol_wt="31389" Region 16..101 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 103..200 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 209..289 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..292 /gene="ORT1" /locus_tag="YOR130C" /gene_synonym="ARG11" /coded_by="NM_001183549.4:1..879" /experiment="EXISTENCE:direct assay:GO:0000064 L-ornithine transmembrane transporter activity [PMID:9237680]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:8798783]" /experiment="EXISTENCE:direct assay:GO:1990575 mitochondrial L-ornithine transmembrane transport [PMID:9237680]" /experiment="EXISTENCE:mutant phenotype:GO:0006526 L-arginine biosynthetic process [PMID:8798783]" /note="Ornithine transporter of the mitochondrial inner membrane; exports ornithine from mitochondria as part of arginine biosynthesis; functionally complemented by human ortholog, SLC25A15, which is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome, but HHH-associated variants fail to complement" /db_xref="GeneID:854297" /db_xref="SGD:S000005656" ORIGIN 1 medskkkgli egaildiing siagacgkvi efpfdtvkvr lqtqasnvfp ttwscikfty 61 qnegiargff qgiasplvga clenatlfvs ynqcskflek htnvsplgqi lisggvagsc 121 aslvltpvel vkcklqvanl qvasaktkht kvlptikaii terglaglwq gqsgtfires 181 fggvawfaty eivkkslkdr hslddpkrde skiwellisg gsaglafnas ifpadtvksv 241 mqtehisltn avkkifgkfg lkgfyrglgi tlfravpana avfyifetls al // LOCUS NP_014774 218 aa linear PLN 30-JUN-2025 DEFINITION putative haloacid dehalogenase-like hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014774 VERSION NP_014774.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183550.1 REFERENCE 1 (residues 1 to 218) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 218) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 218) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 218) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 218) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10905. Method: conceptual translation. FEATURES Location/Qualifiers source 1..218 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..218 /product="putative haloacid dehalogenase-like hydrolase" /calculated_mol_wt="24709" Region 13..211 /region_name="Gph" /note="Phosphoglycolate phosphatase, HAD superfamily [Energy production and conversion]; COG0546" /db_xref="CDD:440312" CDS 1..218 /locus_tag="YOR131C" /coded_by="NM_001183550.1:1..657" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0033883 pyridoxal phosphatase activity [PMID:26071590]" /note="Putative haloacid dehalogenase-like hydrolase; non-essential gene; overexpression causes a cell cycle delay or arrest; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854299" /db_xref="SGD:S000005657" ORIGIN 1 mtklqglqgl khikavvfdm dgtlclpqpw mfpamrnaig ledksidilh fidtlpteke 61 kkeahdriel veakamkemq pqpglvdimr yltkngiskn ictrnvgapv etfvkrfips 121 elsrfdyivt refrptkpqp dpllhiaskl nirplemimv gdsfddmksg rsagcftvll 181 knhvnghlll ehkelvdvsv edlseiieli qnmnkesf // LOCUS NP_014775 551 aa linear PLN 30-JUN-2025 DEFINITION retromer subunit VPS17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014775 VERSION NP_014775.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183551.3 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10906. On Jul 30, 2012 this sequence version replaced NP_014775.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..551 /product="retromer subunit VPS17" /calculated_mol_wt="63073" Region 85..223 /region_name="PX_Vps17p" /note="The phosphoinositide binding Phox Homology domain of yeast sorting nexin Vps17p; cd06891" /db_xref="CDD:132801" Site order(152..154,177..178,193) /site_type="other" /note="putative phosphoinositide binding site [chemical binding]" /db_xref="CDD:132801" Region 239..462 /region_name="BAR_Vps17p" /note="The Bin/Amphiphysin/Rvs (BAR) domain of yeast Sorting Nexin Vps17p; cd07625" /db_xref="CDD:153309" Site order(264,267..268,271..272,274..275,278,281..282,285, 292..293,295..296,299,302..303,306..307,317,424,427..428, 430..432,435,438..439,441..443,445..446,449..450,452..453, 456..457,459..460) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153309" CDS 1..551 /gene="VPS17" /locus_tag="YOR132W" /gene_synonym="PEP21; VPT3" /coded_by="NM_001183551.3:1..1656" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:mutant phenotype:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:mutant phenotype:GO:0140318 protein transporter activity [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0005768 endosome [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0030904 retromer complex [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0030905 retromer, tubulation complex [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:9700157]" /experiment="EXISTENCE:physical interaction:GO:0140318 protein transporter activity [PMID:9700157]" /note="Subunit of the membrane-associated retromer complex; essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation; required for recruiting the retromer complex to the endosome membranes" /db_xref="GeneID:854300" /db_xref="SGD:S000005658" ORIGIN 1 mtsavpydpy ddldnnpfae pqeedsepaa tttdgsssms eervgteqta asvqdngtan 61 niqnglgeeg natrsktsne hnenqqpsqp servilpers dekkkytlla kvtglerfgs 121 atgkkenpti ifdcstnlpt frkqqyknvk ksyeefhqlf kylnvaiqes fvptlpsayt 181 tfginseedr mkvtrnfqlw fnrlsqdpli irneevaffi esdfntytpi nkskslasgl 241 krktlkqlap pydeitelae frplvksiyv vsqslqekll rvsrnrkmmv qeenafgqdf 301 vnldehnkly rrygkiltav gdidsiiatm dmatlydgle wivrdayavk ealtnrhfim 361 rnlvqaqqns kakqeqarrf rsrrdinpmk idealrqlka aakneqvltl klqritsnmi 421 ierkqwiswy eewirssike ftlrkieyer kkltllervr sdirkadeng glsrlgrhav 481 snnnsdtsqt lkgdswtges nrksqipink iahtefddel fteddgynsq dsdttslnar 541 haasllgmst k // LOCUS NP_014776 842 aa linear PLN 30-JUN-2025 DEFINITION elongation factor 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014776 VERSION NP_014776.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183552.1 REFERENCE 1 (residues 1 to 842) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 842) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 842) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 842) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 842) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10907. Method: conceptual translation. FEATURES Location/Qualifiers source 1..842 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..842 /product="elongation factor 2" /calculated_mol_wt="93158" Region 1..842 /region_name="PTZ00416" /note="elongation factor 2; Provisional" /db_xref="CDD:240409" CDS 1..842 /gene="EFT1" /locus_tag="YOR133W" /coded_by="NM_001183552.1:1..2529" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16950777]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:16950777|PMID:10835368]" /experiment="EXISTENCE:direct assay:GO:0051087 protein-folding chaperone binding [PMID:30876804]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:16950777]" /experiment="EXISTENCE:mutant phenotype:GO:0045901 positive regulation of translational elongation [PMID:19338753]" /experiment="EXISTENCE:mutant phenotype:GO:1990145 maintenance of translational fidelity [PMID:16950777]" /note="Elongation factor 2 (eEF2, EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication" /db_xref="GeneID:854301" /db_xref="SGD:S000005659" ORIGIN 1 mvaftvdqmr slmdkvtnvr nmsviahvdh gkstltdslv qragiisaak agearftdtr 61 kdeqergiti kstaislyse msdedvkeik qktdgnsfli nlidspghvd fssevtaalr 121 vtdgalvvvd tiegvcvqte tvlrqalger ikpvvvinkv drallelqvs kedlyqtfar 181 tvesvnvivs tyadevlgdv qvypargtva fgsglhgwaf tirqfatrya kkfgvdkakm 241 mdrlwgdsff npktkkwtnk dtdaegkple rafnmfildp ifrlftaimn fkkdeipvll 301 ekleivlkgd ekdlegkall kvvmrkflpa adallemivl hlpspvtaqa yraeqlyegp 361 addanciaik ncdpkadlml yvskmvptsd kgrfyafgrv fagtvksgqk vriqgpnyvp 421 gkkddlfika iqrvvlmmgr fvepiddcpa gniiglvgid qfllktgtlt tsetahnmkv 481 mkfsvspvvq vavevknand lpklveglkr lsksdpcvlt ymsesgehiv agtgelhlei 541 clqdlehdha gvplkisppv vayretvese ssqtalsksp nkhnriylka epideevsla 601 iengiinprd dfkararima ddygwdvtda rkiwcfgpdg ngpnlvidqt kavqylheik 661 dsvvaafqwa tkegpifgee mrsvrvnild vtlhadaihr gggqiiptmr ratyagflla 721 dpkiqepvfl veiqcpeqav ggiysvlnkk rgqvvseeqr pgtplftvka ylpvnesfgf 781 tgelrqatgg qafpqmvfdh wstlgsdpld ptskageivl aarkrhgmke evpgwqeyyd 841 kl // LOCUS NP_014777 409 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein BAG7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014777 VERSION NP_014777.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183553.3 REFERENCE 1 (residues 1 to 409) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 409) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 409) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 409) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 409) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10908. On Jul 30, 2012 this sequence version replaced NP_014777.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..409 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..409 /product="GTPase-activating protein BAG7" /calculated_mol_wt="46085" Region 47..257 /region_name="RhoGAP_fSAC7_BAG7" /note="RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of...; cd04396" /db_xref="CDD:239861" Site order(98,139,143,217,220..221,243) /site_type="other" /note="putative GTPase interaction site [polypeptide binding]" /db_xref="CDD:239861" Site 98 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:239861" CDS 1..409 /gene="BAG7" /locus_tag="YOR134W" /coded_by="NM_001183553.3:1..1230" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:12207708|PMID:11591390]" /experiment="EXISTENCE:genetic interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:12207708]" /note="Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a bud growth by regulating actin cytoskeleton organization and cell wall biosynthesis, resulting in the downregulation of Rho1p; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication" /db_xref="GeneID:854302" /db_xref="SGD:S000005660" ORIGIN 1 mfnmnllstp sseegspqnr sssmssvegk kdrdtftnlq nefdgkvfgv sleeslkvaq 61 eeviiqkstn eigsipvvia ksgkylkena ldttgifria gsnkrvrelq avfskppdyg 121 rkfegwcdfn vhdiatllkr ylnslseplv plalydifrn pilenpkine hkeqiikdye 181 diymllpqqn rhlilylaal lnlfarnekk nlmsasnlaa ivqpsllshp kdemcpkeye 241 asrtviefli lhasdiipnt ekankdtmph agtvakfnni tvpemaidsd eedfvhpsid 301 dhmlprsral sdsnnftihh hhhhhhalfp spidfdnngl svprsfkgrt lsaeslsprl 361 skllgnvgns sntgikdpte rvprgehktk hkqrqswlrr ltspsrtqp // LOCUS NP_014779 369 aa linear PLN 30-JUN-2025 DEFINITION isocitrate dehydrogenase (NAD(+)) IDH2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014779 VERSION NP_014779.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183555.1 REFERENCE 1 (residues 1 to 369) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 369) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 369) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 369) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10909. Method: conceptual translation. FEATURES Location/Qualifiers source 1..369 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..369 /product="isocitrate dehydrogenase (NAD(+)) IDH2" /EC_number="1.1.1.41" /calculated_mol_wt="39608" Region 34..369 /region_name="Iso_dh" /note="Isocitrate/isopropylmalate dehydrogenase; cl00445" /db_xref="CDD:444908" CDS 1..369 /gene="IDH2" /locus_tag="YOR136W" /coded_by="NM_001183555.1:1..1110" /experiment="EXISTENCE:direct assay:GO:0004449 isocitrate dehydrogenase (NAD+) activity [PMID:16884682]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:11914276|PMID:24769239|PMID:11502169|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006102 isocitrate metabolic process [PMID:16884682]" /experiment="EXISTENCE:direct assay:GO:0045242 isocitrate dehydrogenase complex (NAD+) [PMID:16884682]" /note="Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase; complex catalyzes oxidation of isocitrate to alpha-ketoglutarate in TCA cycle; targeted to vacuole via AP-3 pathway" /db_xref="GeneID:854303" /db_xref="SGD:S000005662" ORIGIN 1 mlrntffrnt srrflatvkq psigrytgkp npstgkytvs fiegdgigpe isksvkkifs 61 aanvpiewes cdvspifvng lttipdpavq sitknlvalk gplatpigkg hrslnltlrk 121 tfglfanvrp aksiegfktt yenvdlvlir entegeysgi ehivcpgvvq siklitrdas 181 erviryafey araigrprvi vvhkstiqrl adglfvnvak elskeypdlt letelidnsv 241 lkvvtnpsay tdavsvcpnl ygdilsdlns glsagslglt psanighkis ifeavhgsap 301 diagqdkanp talllssvmm lnhmgltnha dqiqnavlst iasgpenrtg dlagtattss 361 fteavikrl // LOCUS NP_014780 622 aa linear PLN 30-JUN-2025 DEFINITION Sia1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014780 VERSION NP_014780.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183556.3 REFERENCE 1 (residues 1 to 622) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 622) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 622) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 622) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10910. On Jul 30, 2012 this sequence version replaced NP_014780.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..622 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..622 /product="Sia1p" /calculated_mol_wt="71715" Region 309..575 /region_name="MPP_superfamily" /note="metallophosphatase superfamily, metallophosphatase domain; cl13995" /db_xref="CDD:472684" Site order(317,319,356,390..391,487,550) /site_type="active" /db_xref="CDD:277317" Site order(317,319,356,390,487,550) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277317" CDS 1..622 /gene="SIA1" /locus_tag="YOR137C" /coded_by="NM_001183556.3:1..1869" /experiment="EXISTENCE:mutant phenotype:GO:1902600 proton transmembrane transport [PMID:9450541]" /note="Protein of unassigned function; involved in activation of the Pma1p plasma membrane H+-ATPase by glucose; contains peptide signal for membrane localization" /db_xref="GeneID:854305" /db_xref="SGD:S000005663" ORIGIN 1 mrlhyrrrfn flrrilfilc itslylsrds lklhaknvlm dhnvaeyhgg middiqilrc 61 yhwyrqcssl yapklhpsnt akkikdknsi lwtrvsknit vetlyslqsg pfynsylyvh 121 lkdfqsnpkn tikelaiard saliplqvlr dinklvkssd ssvfhnhvyl rekptsswwk 181 llfgisvdtd niavfgeewv ykgsgiwcky ilndddndap itnleiylgs sfiesrpswk 241 evihefhrnn ipslpisitr kletknhhhk fsngllgslr tpskdiniqv dadykitsph 301 iqfsrgqrsf kilqitdfhf kctdnsmtvi neiktvnfid rvlasenpdl vvitgdllds 361 hntidyqtci mkvvqpmisn kipyaislgv sdesnlatsa qirdfirnlp ytfnnvasee 421 ghmaievsfk kkltkntlle rdidtedetn psealffvfd sfapvnnflq dyndligkid 481 fglafqyfpl seyrphglfp iigqynerst ltvdtprsrg qvsmtingkh yksfldilsl 541 wnikgvscgh ehnndcclqs knemwlcygg sagiglpriq giyptvrlfn lddildeits 601 wkrnsnlvde vydyqyiykg kq // LOCUS NP_014781 671 aa linear PLN 30-JUN-2025 DEFINITION Rup1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014781 VERSION NP_014781.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183557.1 REFERENCE 1 (residues 1 to 671) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 671) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 671) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 671) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 671) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10911. Method: conceptual translation. FEATURES Location/Qualifiers source 1..671 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..671 /product="Rup1p" /calculated_mol_wt="75230" Region 4..41 /region_name="UBA_RUP1p" /note="UBA domain found in yeast UBA domain-containing protein RUP1p and similar proteins; cd14307" /db_xref="CDD:270492" CDS 1..671 /gene="RUP1" /locus_tag="YOR138C" /coded_by="NM_001183557.1:1..2016" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:1902499 positive regulation of protein autoubiquitination [PMID:24069405]" /experiment="EXISTENCE:mutant phenotype:GO:0016579 protein deubiquitination [PMID:15933713]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15933713]" /note="Protein that regulates ubiquitination of Rsp5p; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:854306" /db_xref="SGD:S000005664" ORIGIN 1 mmdnqavksl lemgipheva vdalqrtggn leaavnfifs nelpeqaemg eendgsqpri 61 senkivagtk pcdvpnngdq didmpdvsgv dvdydddedi tdersgsnst sgcrvtaqny 121 drysisetsi pppsysivqh nefksnvgdp tvvlplplns liesyfglfa lltavyfphv 181 flkpdfkdln yradwfkgss ftepkyrlay ceaedgstts eivlasgpne glqphllwql 241 qklisvvntr kcerafvsak vftsslepql rskladsehl yevlpafiks lavdlemcpg 301 irdretrslf issalhtpnk neppmetfls lfhflpeeyd snlykmfnvl lypeeeeeee 361 dvirggeqee aryvepentl kevapvltil fneletntes vslpngvdip lefypqlytk 421 qckdqlirhi iskrkqartr srcllqeine lksyqgknis tilestlayl qtipddanne 481 aakqiaslkd tlnsaraakm eeykdlaskl hgewnlshpe thiintakql glienpyilt 541 maalspysyf irsrngawsw iqsntlgtef kvkkcsspsv vqeaikhgtk yasetplmfi 601 yceegkipte evvaealksn sgclkfaedd qnslktlrsq ffdgmgdpeq atnninngnd 661 ndndddidsd n // LOCUS NP_014783 766 aa linear PLN 30-JUN-2025 DEFINITION Sfl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014783 VERSION NP_014783.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183559.4 REFERENCE 1 (residues 1 to 766) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 766) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 766) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 766) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 766) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10912. On Jul 30, 2012 this sequence version replaced NP_014783.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..766 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..766 /product="Sfl1p" /calculated_mol_wt="83214" Region 53..381 /region_name="HSF1" /note="Heat shock transcription factor [Transcription]; COG5169" /db_xref="CDD:227497" Region <540..722 /region_name="PHA03247" /note="large tegument protein UL36; Provisional" /db_xref="CDD:223021" CDS 1..766 /gene="SFL1" /locus_tag="YOR140W" /coded_by="NM_001183559.4:1..2301" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12024012|PMID:11399075|PMID:9755175]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12024012]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:27336723]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9811878]" /experiment="EXISTENCE:genetic interaction:GO:2000218 negative regulation of invasive growth in response to glucose limitation [PMID:9811878]" /experiment="EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:9811878]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12024012|PMID:15466424|PMID:9811878]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27336723|PMID:17594096]" /experiment="EXISTENCE:mutant phenotype:GO:2000218 negative regulation of invasive growth in response to glucose limitation [PMID:15466424|PMID:9811878]" /experiment="EXISTENCE:mutant phenotype:GO:2000221 negative regulation of pseudohyphal growth [PMID:12024012|PMID:9811878]" /experiment="EXISTENCE:physical interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9755175|PMID:11399075]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11399075]" /note="Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; has direct role in INO1 transcriptional memory; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p; premature stop codon (C1430T, Q477-stop) in SK1 background is linked to the aggressively invasive phenotype of SK1 relative to BY4741 (S288C)" /db_xref="GeneID:854307" /db_xref="SGD:S000005666" ORIGIN 1 mseeetvsap apastpapag tdvgsggaaa gianagaegg dgaedvkkhg skmlvgprpp 61 qnaifihkly qiledeslhd liwwtpsgls fmikpverfs kalatyfkht nitsfvrqln 121 iygfhkvshd hssndansgd dantnddsnt hddnsgnkns sgdentgggv qekeksnptk 181 iwefkhssgi fkkgdieglk hikrrassrn nssinsrkns snqnydidsg arvrpssiqd 241 pstssnsfgn fvpqipgann sipeyfnnsh vtyenanhap lesnnpemqe qnrppnfqde 301 tlkhlkeinf dmvkiiesmq hfislqhsfc sqsftfknvs kkksenivkd hqkqlqafes 361 dmltfkqhvm srahrtidsl cavnaaataa svapapapts tsayapksqy emmvppgnqy 421 vpqksssttn ipsrfntasv ppsqlfvqyq pqsqqhvtya kqpahvpnfi nqpipiqqlp 481 pqyadtfstp qmmhnpfask nnnkpgntkr tnsvlmdplt paasvgvqgp lnypimninp 541 svrdynkpvp qnmapspiyp inepttrlys qpkmrslgst sslpndrrns plkltprssl 601 nedslypkpr nslkssisgt slsssftlva nnpapirysq qgllrslnka ancapdsvtp 661 ldssvltgpp pknmdnlpav ssnlinspmn vehssslsqa epapqielpq pslpttsttk 721 ntgeadnskr kgsgvyslln qedsstssad pktedkaapa lkkvkm // LOCUS NP_014784 881 aa linear PLN 30-JUN-2025 DEFINITION Arp8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014784 VERSION NP_014784.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183560.1 REFERENCE 1 (residues 1 to 881) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 881) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 881) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 881) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10913. Method: conceptual translation. FEATURES Location/Qualifiers source 1..881 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..881 /product="Arp8p" /calculated_mol_wt="100078" Region 268..876 /region_name="ASKHA_NBD_Arp8-like" /note="nucleotide-binding domain (NBD) of the actin-related protein 8 (Arp8)-like subfamily; cd10206" /db_xref="CDD:466812" Region <767..879 /region_name="Actin_micro" /note="Putative actin-like family; pfam17003" /db_xref="CDD:374929" CDS 1..881 /gene="ARP8" /locus_tag="YOR141C" /coded_by="NM_001183560.1:1..2646" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:20844764]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11011149]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:23644470]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:17320816]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:12887900]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:17320816]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245|PMID:10952318]" /note="Nuclear actin-related protein involved in chromatin remodeling; component of chromatin-remodeling enzyme complexes; has mRNA binding activity" /db_xref="GeneID:854309" /db_xref="SGD:S000005667" ORIGIN 1 msqeeaessi iyeepidipl eddddedele eensvplssq adqenaenes ddsvdnvvgs 61 etprsvtgls vdprdvadee dedeegeded ededdndvdn edendndnan enenelgssr 121 dkrappavqt skrykkypkl dpakappgkk vplhllekrr lgrikaaeef aktlkkigie 181 kvetttlpat glfqplmlin qknyssdylk kddqifalrd rkflrnnnts qisstntpdv 241 idlkslphse asaaplndei dlndptativ ihpgsnsiki gfpkddhpvv vpncvavpkk 301 wldlensehv envclqreqs eefnniksem eknfrermry ykrkvpgnah eqvvsfnens 361 kpeiiseknd pspiewifdd sklyygsdal rcvdekfvir kpfrggsfnv kspyykslae 421 lisdvtklle halnsetlnv kptkfnqykv vlvipdifkk shvetfirvl ltelqfqava 481 iiqeslatcy gagiststcv vnigaaetri acvdegtvle hsaitldygg dditrlfalf 541 llqsdfplqd wkidskhgwl laerlkknft tfqdadvavq lynfmnrspn qptekyefkl 601 fdevmlapla lffpqifkli rtsshknssl efqlpesrdl ftnelndwns lsqfeskegn 661 lycdlnddlk ilnrildahn iidqlqdkpe nygntlkenf aplekaivqs ianasitadv 721 trmnsfysni livggsskip aldfiltdri niwrpsllss asfpqfykkl tkeikdlegh 781 yvnapdkted enkqilqaqi kekiveelee qhqniehqng nehifpvsii ppprdmnpal 841 iiwkgasvla qiklveelfi tnsdwdvhgs rilqykcift y // LOCUS NP_014785 329 aa linear PLN 30-JUN-2025 DEFINITION succinate--CoA ligase (GDP-forming) subunit alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_014785 VERSION NP_014785.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183561.3 REFERENCE 1 (residues 1 to 329) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 329) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 329) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 329) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 329) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10914. On Jul 30, 2012 this sequence version replaced NP_014785.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..329 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..329 /product="succinate--CoA ligase (GDP-forming) subunit alpha" /EC_number="6.2.1.5" /calculated_mol_wt="34901" Region 30..321 /region_name="SucD" /note="Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; COG0074" /db_xref="CDD:439844" CDS 1..329 /gene="LSC1" /locus_tag="YOR142W" /coded_by="NM_001183561.3:1..990" /experiment="EXISTENCE:direct assay:GO:0004775 succinate-CoA ligase (ADP-forming) activity [PMID:9874242]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9874242|PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006104 succinyl-CoA metabolic process [PMID:9874242]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:15692048]" /experiment="EXISTENCE:mutant phenotype:GO:0004775 succinate-CoA ligase (ADP-forming) activity [PMID:9874242]" /note="Alpha subunit of succinyl-CoA ligase; succinyl-CoA ligase is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated" /db_xref="GeneID:854310" /db_xref="SGD:S000005668" ORIGIN 1 mlrstvskas lkicrhfhre sipydktikn lllpkdtkvi fqgftgkqgt fhasisqeyg 61 tnvvggtnpk kagqthlgqp vfasvkdaik etgatasaif vpppiaaaai kesieaeipl 121 avcitegipq hdmlyiaeml qtqdktrlvg pncpgiinpa tkvrigiqpp kifqagkigi 181 isrsgtltye avqqttktdl gqslvigmgg dafpgtdfid alklfledet tegiimlgei 241 ggkaeieaaq flkeynfsrs kpmpvasfia gtvagqmkgv rmghsgaive gsgtdaeskk 301 qalrdvgvav vespgylgqa lldqfakfk // LOCUS NP_058184 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058184 VERSION NP_058184.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184385.3 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10916. On Jul 30, 2012 this sequence version replaced NP_058184.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..440 /product="gag protein" /calculated_mol_wt="48967" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YOR142W-A" /coded_by="NM_001184385.3:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:854312" /db_xref="SGD:S000007351" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr pitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_058183 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058183 VERSION NP_058183.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184386.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10915. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198406" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YOR142W-B" /coded_by="join(NM_001184386.2:1..1305, NM_001184386.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:854313" /db_xref="SGD:S000007352" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr pitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd kyydrkeidp krvinsmfif nrkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnsnk 1441 riiaklkmqy dtkiinlges ddeiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npngrklgap gqpglyinqq eleleeddyk mkvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsk qvldmtyeli qfiwntrdkq liwhkskpvk ptnklvvisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qeldkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_014786 319 aa linear PLN 30-JUN-2025 DEFINITION thiamine diphosphokinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014786 VERSION NP_014786.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183562.1 REFERENCE 1 (residues 1 to 319) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 319) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 319) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 319) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10917. Method: conceptual translation. FEATURES Location/Qualifiers source 1..319 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..319 /product="thiamine diphosphokinase" /EC_number="2.7.6.2" /calculated_mol_wt="36485" Region 40..306 /region_name="TPK" /note="Thiamine pyrophosphokinase; cd07995" /db_xref="CDD:153431" Site order(44..46,68..70,97,99..100,122..127,191,193..195,198, 202,270,272,285..288) /site_type="active" /db_xref="CDD:153431" Site order(70,74,77,122..124,128,192,194..201,203..204,225,227, 250,252,254,256..257,284,286..287) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:153431" Site order(97,122..125,270,272,285..288) /site_type="other" /note="thiamine binding site [chemical binding]" /db_xref="CDD:153431" CDS 1..319 /gene="THI80" /locus_tag="YOR143C" /coded_by="NM_001183562.1:1..960" /experiment="EXISTENCE:direct assay:GO:0004788 thiamine diphosphokinase activity [PMID:18652651|PMID:8394343]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004788 thiamine diphosphokinase activity [PMID:8394343]" /experiment="EXISTENCE:mutant phenotype:GO:0009229 thiamine diphosphate biosynthetic process [PMID:8394343]" /note="Thiamine pyrophosphokinase; phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)" /db_xref="GeneID:854314" /db_xref="SGD:S000005669" ORIGIN 1 mseecienpe rikigtdlin irnkmnlkel ihpnedenst llilnqkidi prplfykiwk 61 lhdlkvcadg aanrlydyld ddetlrikyl pnyiigdlds lsekvykyyr knkvtiikqt 121 tqystdftkc vnlislhfns pefrslisnk dnlqsnhgie lekgihtlyn tmteslvfsk 181 vtpisllalg giggrfdqtv hsitqlytls enasyfklcy mtptdlifli kkngtlieyd 241 pqfrntcign cgllpigeat lvketrglkw dvknwptsvv tgrvsssnrf vgdnccfidt 301 kddiilnvei fvdklidfl // LOCUS NP_014787 791 aa linear PLN 30-JUN-2025 DEFINITION Elg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014787 VERSION NP_014787.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183563.3 REFERENCE 1 (residues 1 to 791) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 791) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 791) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 791) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 791) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 791) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 791) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 791) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 791) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10918. On Jul 30, 2012 this sequence version replaced NP_014787.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..791 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..791 /product="Elg1p" /calculated_mol_wt="91131" Region 335..>508 /region_name="PRK04195" /note="replication factor C large subunit; Provisional" /db_xref="CDD:235250" CDS 1..791 /gene="ELG1" /locus_tag="YOR144C" /gene_synonym="RTT110" /coded_by="NM_001183563.3:1..2376" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18482875]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:19430531]" /experiment="EXISTENCE:mutant phenotype:GO:0000724 double-strand break repair via homologous recombination [PMID:17170004]" /experiment="EXISTENCE:mutant phenotype:GO:0006260 DNA replication [PMID:23499004]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:12912927]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:19430531]" /experiment="EXISTENCE:mutant phenotype:GO:0010526 transposable element silencing [PMID:11779788]" /experiment="EXISTENCE:mutant phenotype:GO:0031507 heterochromatin formation [PMID:29440488]" /experiment="EXISTENCE:physical interaction:GO:0031391 Elg1 RFC-like complex [PMID:12909721]" /note="Subunit of an alternative replication factor C complex; important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication" /db_xref="GeneID:854315" /db_xref="SGD:S000005670" ORIGIN 1 mkrhvslsdi ltgnkrkvrr qdalqitidd endtesgtfd artakhddss viflnhsvvk 61 pieavstnhk sakeflmtkr tkekcddddd dlivisdksp ksetncskia lsqeheddis 121 iistsrikss llneraskik nflkhettdt fkrlnsiskl neiepplplh qsifpvgdke 181 lsdrsvdipl pfrtipplnh nflpsdyesl kdknsascip vryqapvllg tnikrnttlt 241 wpqlfkpvtl kqvliepklk lriknwiets fhtlekptlr nrllnrinpn kqqgsgdela 301 nfivpdleed enlrpdfyrn geansslsef vplmilhgns igkktliqti mreiagddns 361 yqiyevnsnm nrskkdlldi lldfttthyv kdsskrksdy glvlfndvdv lfkehdrgyw 421 amisklcefs rrplvltckd lslvpselia laseqnslfh tkkiststvy afltkylksl 481 eievcddwlr dvvkqnnadi rkclmhlqfw cvdteadlis sknrlpvlts tlgssvkdis 541 qltdllsind vigqatlnrs mvrqeidstt mtpekvntfq dqnlddemkl kfdyvidykl 601 hlndpnrqpl lpfelniyqh iqeqlearys yvreanhrld neylvnrfkk mtestlnfla 661 sripkydhlq sarrtrnskk isdilnqfkg iyndetlnen aeidllsatt qqikaeinpf 721 vfeiaksdan vknenkqife lhsenvserr ykdlvyqlsq egvlknvwfn adpsivvrkw 781 ehlhsgfskn k // LOCUS NP_014788 274 aa linear PLN 30-JUN-2025 DEFINITION Pno1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014788 VERSION NP_014788.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183564.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10919. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..274 /product="Pno1p" /calculated_mol_wt="30200" Region 94..174 /region_name="KH-I_PNO1_rpt1" /note="first type I K homology (KH) RNA-binding domain found in partner of NOB1 (PNO1) and similar proteins; cd22391" /db_xref="CDD:411819" Site order(94..95,97..98,106..107,109..110,113,117,121,123, 125..133,138,140,144,149..150,153,157,167,169..170, 172..173) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:411819" Site order(103..108,132,135) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:411819" Region 176..271 /region_name="KH-I_PNO1_rpt2" /note="second type I K homology (KH) RNA-binding domain found in partner of NOB1 (PNO1) and similar proteins; cd22392" /db_xref="CDD:411820" Site order(176..181,183..184,189..192,199..200,209,211,214, 217..218,221..223,234,237,244,248..249,252,271) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:411820" Site order(197,199..200,202..204,206..210,212..214,226,241, 253..256,258,260,264) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:411820" CDS 1..274 /gene="PNO1" /locus_tag="YOR145C" /gene_synonym="DIM2; RRP20" /coded_by="NM_001183564.1:1..825" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12502737]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10923024]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:18755838]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:12502737]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:18755838]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12736301]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12736301]" /experiment="EXISTENCE:mutant phenotype:GO:0042255 ribosome assembly [PMID:18755838]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:12502737]" /experiment="EXISTENCE:physical interaction:GO:0043248 proteasome assembly [PMID:12502737]" /note="Essential nucleolar protein required for pre-18S rRNA processing; interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain" /db_xref="GeneID:854317" /db_xref="SGD:S000005671" ORIGIN 1 mvaptalkka tvtpvsgqdg gssriiginn tesidedddd dvllddsdnn takeevegee 61 gsrktheskt vvvddqgkpr ftsasktqgn kikfesrkim vpphrmtplr nswtkiyppl 121 vehlklqvrm nlktksvelr tnpkfttdpg alqkgadfik aftlgfdldd siallrlddl 181 yietfevkdv ktltgdhlsr aigriagkdg ktkfaienat rtrivladsk ihilggfthi 241 rmaresvvsl ilgsppgkvy gnlrtvasrl kery // LOCUS NP_014790 622 aa linear PLN 30-JUN-2025 DEFINITION Mdm32p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014790 VERSION NP_014790.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183566.3 REFERENCE 1 (residues 1 to 622) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 622) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 622) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 622) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10920. On Jul 30, 2012 this sequence version replaced NP_014790.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..622 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..622 /product="Mdm32p" /calculated_mol_wt="71897" Region 90..487 /region_name="MDM31_MDM32" /note="Yeast mitochondrial distribution and morphology (MDM) proteins; pfam08118" /db_xref="CDD:429828" CDS 1..622 /gene="MDM32" /locus_tag="YOR147W" /coded_by="NM_001183566.3:1..1869" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:15631992]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:15631992]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:16020778]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266|PMID:16020778]" /note="Mitochondrial inner membrane protein with similarity to Mdm31p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34; variation between SK1 and S288C at residues 182 and 262 impacts invasive growth and mitochondrial network structure" /db_xref="GeneID:854318" /db_xref="SGD:S000005673" ORIGIN 1 mlitrlrvpt ikrpllpits hlvrhcirty vatnhgnvrp fitpyksslp vrcliaqrhi 61 rtfpsndkft tkasnietil lrknnerefk qslladaknf qerfkinlkw iliknnrpfs 121 lneisiiasw lilsqilwli lstttfisfy lfvinsvfsq eyihekkiye rllkwllkdh 181 kcsnqdleit fspedkasml vlspdwesns ilikrlnvrd eildldlkfh hinlnvslkn 241 wllgrglitn vsiygirgcl nlsnfinlvn sfqgdqkten flktlnnvei tdseillkqs 301 lsaqetpslk fsiynlslpr lrlnhfisdi lsaktfsgsi nnslfnlfkr qqkltavien 361 nnknrmassk fdftdnnqen yrtvthqddp nyvttlrlnf inindlkfng dgkfnwlkdg 421 qveiladiml tnstshlsse skyavvdlkv tcrdlkttfp qeppvlstgd sivsldelkp 481 iitfinsyeg manpilkdfs enerltnsii wnspnvsinr qrksyplttk vtsnstkeii 541 kfhnqpntna neivlrckmv knlsdlqlin inqildqitm elyvdltkiv edwefknknd 601 wmkqwgttfa sqlllfgfga mv // LOCUS NP_014791 185 aa linear PLN 30-JUN-2025 DEFINITION spliceosome ATPase-activating subunit SPP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014791 VERSION NP_014791.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183567.1 REFERENCE 1 (residues 1 to 185) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 185) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 185) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 185) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10921. Method: conceptual translation. FEATURES Location/Qualifiers source 1..185 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..185 /product="spliceosome ATPase-activating subunit SPP2" /calculated_mol_wt="20517" Region 93..151 /region_name="G-patch_2" /note="G-patch domain; pfam12656" /db_xref="CDD:432700" CDS 1..185 /gene="SPP2" /locus_tag="YOR148C" /coded_by="NM_001183567.1:1..558" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:25561498]" /experiment="EXISTENCE:direct assay:GO:0005681 spliceosomal complex [PMID:7493316]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:7493316]" /note="Essential protein that promotes the first step of splicing; required for the final stages of spliceosome maturation and activation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction; stimulates Prp2p ATPase activity" /db_xref="GeneID:854319" /db_xref="SGD:S000005674" ORIGIN 1 mskfslklgs ktlkkniskk tkkknslqka nlfdwddaet aslshkpqsk ikiqsidkfd 61 ldeessskkk lviklsenad tkkndaplve yvtekeynev pveefgdall rgmgwesdse 121 qdskgdktqs rnkdvsnvsq ihpdglgiga klnkainvee asfmpvvkid kitgtkvddd 181 kknks // LOCUS NP_014792 516 aa linear PLN 30-JUN-2025 DEFINITION glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014792 VERSION NP_014792.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183568.4 REFERENCE 1 (residues 1 to 516) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 516) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 516) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 516) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10922. On Jul 30, 2012 this sequence version replaced NP_014792.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..516 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..516 /product="glycosylphosphatidylinositol-alpha 1,2 mannosyltransferase" /calculated_mol_wt="59752" Region 6..400 /region_name="Glyco_transf_22" /note="Alg9-like mannosyltransferase family; pfam03901" /db_xref="CDD:281842" CDS 1..516 /gene="SMP3" /locus_tag="YOR149C" /gene_synonym="LAS2; SAP2" /coded_by="NM_001183568.4:1..1551" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000026 alpha-1,2-mannosyltransferase activity [PMID:11356840]" /experiment="EXISTENCE:mutant phenotype:GO:0006276 plasmid maintenance [PMID:2005867]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:11356840]" /note="Alpha 1,2-mannosyltransferase; involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure" /db_xref="GeneID:854320" /db_xref="SGD:S000005675" ORIGIN 1 mmryqwwlyl vyaiglmlcl gpsyihpdeh fqcieilamq fmkvkgtipw efkskfaars 61 ygplllvygp lftilesfpe iqdnpalily smrlqnyvmy llcyhflipk lirderkavq 121 fikkslllts yvtwtyqtht fsnsietlal istltvmedm vnekniqrsn fknsvilgli 181 fsfgvfnrvt fpafiflpcl ilfwkfyrvh wksfslllls fsfssclfvl idtniynngk 241 gfvitplnnl kynlnvqnlq vhglhpryth llvnlpqivg pvlllaifsg ykldklstya 301 iisgllflsf fqhqelrflv plvpllvtnl nwtplsstlv nkkifkgtwl lfniimafim 361 gishqagiiq flgdyfhfrt eqmgvhiwwk tyspptwmym snnltvssli ntqdgiesid 421 evafsvgnhh vidlkgcdlp lltetirrlr lngsitpltl vtpnsmtsel kklkrdgtin 481 lipkrnylfh ldldhldfnd fttfkpgltv ysiell // LOCUS NP_014793 163 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL13m MRPL23 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014793 VERSION NP_014793.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183569.1 REFERENCE 1 (residues 1 to 163) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 163) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 163) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 163) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10923. Method: conceptual translation. FEATURES Location/Qualifiers source 1..163 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..163 /product="mitochondrial 54S ribosomal protein uL13m MRPL23" /calculated_mol_wt="18332" Region 4..147 /region_name="rplM_bact" /note="ribosomal protein L13, bacterial type; TIGR01066" /db_xref="CDD:162186" Site order(27,29..30,33,36,40,68,70,99..100,106..108,110..112, 114..116,118,120,124,127..128) /site_type="other" /note="23S rRNA interface [nucleotide binding]" /db_xref="CDD:238230" Site 100 /site_type="other" /note="L3 interface [polypeptide binding]" /db_xref="CDD:238230" CDS 1..163 /gene="MRPL23" /locus_tag="YOR150W" /gene_synonym="uL13m" /coded_by="NM_001183569.1:1..492" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit; localizes to vacuole in response to H2O2" /db_xref="GeneID:854321" /db_xref="SGD:S000005676" ORIGIN 1 msqkighsgl afarlwhhvd vardkrtlgr lasaiaitli grhkpvyhps qdcgdyvvvt 61 ncqkirvtgk kfeqktywsh sgrpgqlklq tmnkvvadkg fgeilkkavs gmlpknklrk 121 qrldrlkvfd gsenpykqni tafaheqssi peplkesifn qlk // LOCUS NP_014794 1224 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase II core subunit RPB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014794 VERSION NP_014794.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183570.3 REFERENCE 1 (residues 1 to 1224) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1224) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1224) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1224) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1224) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10924. On Jul 30, 2012 this sequence version replaced NP_014794.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1224 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1224 /product="DNA-directed RNA polymerase II core subunit RPB2" /EC_number="2.7.7.6" /calculated_mol_wt="138621" Region 31..1216 /region_name="Ricin_B_lectin" /note="Ricin-type beta-trefoil lectin domain; cl47023" /db_xref="CDD:481363" CDS 1..1224 /gene="RPB2" /locus_tag="YOR151C" /gene_synonym="RPB150; RPO22; SIT2; SOH2" /coded_by="NM_001183570.3:1..3675" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:26945063]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:8288647]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1331084|PMID:2186966|PMID:2183013]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:2406558]" /note="RNA polymerase II second largest subunit B150; part of central core; similar to bacterial beta subunit" /db_xref="GeneID:854322" /db_xref="SGD:S000005677" ORIGIN 1 msdlanseky ydedpygfed esapitaeds wavisaffre kglvsqqlds fnqfvdytlq 61 diicedstli leqlaqhtte sdnisrkyei sfgkiyvtkp mvnesdgvth alypqearlr 121 nltyssglfv dvkkrtyeai dvpgrelkye liaeesedds esgkvfigrl pimlrskncy 181 lseatesdly klkecpfdmg gyfiingsek vliaqersag nivqvfkkaa pspishvaei 241 rsalekgsrf istlqvklyg regssartik atlpyikqdi piviifralg iipdgeileh 301 icydvndwqm lemlkpcved gfviqdreta ldfigrrgta lgikkekriq yakdilqkef 361 lphitqlegf esrkafflgy minrlllcal drkdqddrdh fgkkrldlag pllaqlfktl 421 fkkltkdifr ymqrtveeah dfnmklaina ktitsglkya latgnwgeqk kamssragvs 481 qvlnrytyss tlshlrrtnt pigrdgklak prqlhnthwg lvcpaetpeg qacglvknls 541 lmscisvgtd pmpiitflse wgmepledyv phqspdatrv fvngvwhgvh rnparlmetl 601 rtlrrkgdin pevsmirdir ekelkiftda grvyrplfiv eddeslghke lkvrkghiak 661 lmateyqdie ggfedveeyt wssllneglv eyidaeeees iliamqpedl epaeaneend 721 ldvdpakrir vshhattfth ceihpsmilg vaasiipfpd hnqsprntyq samgkqamgv 781 fltnynvrmd tmanilyypq kplgttrame ylkfrelpag qnaivaiacy sgynqedsmi 841 mnqssidrgl frslffrsym dqekkygmsi tetfekpqrt ntlrmkhgty dkldddglia 901 pgvrvsgedv iigkttpisp deeelgqrta yhskrdastp lrstengivd qvlvttnqdg 961 lkfvkvrvrt tkipqigdkf asrhgqkgti gityrredmp ftaegivpdl iinphaipsr 1021 mtvahliecl lskvaalsgn egdaspftdi tvegiskllr ehgyqsrgfe vmynghtgkk 1081 lmaqiffgpt yyqrlrhmvd dkiharargp mqvltrqpve grsrdgglrf gemerdcmia 1141 hgaasflker lmeasdafrv hicgicglmt viaklnhnqf eckgcdnkid iyqihipyaa 1201 kllfqelmam nitprlytdr srdf // LOCUS NP_014795 256 aa linear PLN 30-JUN-2025 DEFINITION Atg40p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014795 VERSION NP_014795.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183571.1 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10925. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..256 /product="Atg40p" /calculated_mol_wt="29562" CDS 1..256 /gene="ATG40" /locus_tag="YOR152C" /coded_by="NM_001183571.1:1..771" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:26040717]" /experiment="EXISTENCE:genetic interaction:GO:0006995 cellular response to nitrogen starvation [PMID:26040717]" /experiment="EXISTENCE:genetic interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:26040717]" /experiment="EXISTENCE:genetic interaction:GO:0061709 reticulophagy [PMID:26040717]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:26040717]" /experiment="EXISTENCE:mutant phenotype:GO:0030674 protein-macromolecule adaptor activity [PMID:26040717]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26040717]" /note="Autophagy receptor with a role in endoplasmic reticulum degradation; involved specifically in autophagy of cortical and cytoplasmic ER in response to nitrogen starvation or rapamycin treatment; acts with COPII subunit Sfb3p; localizes to the cortical and cytoplasmic ER; similar to human FAM134B, which is also involved in ER autophagy and is associated with sensory neuropathy" /db_xref="GeneID:854323" /db_xref="SGD:S000005678" ORIGIN 1 mfnlilwplf lltsvaiplq ltlevvylts svdfskasaa ktatslgqsp vvitiyksll 61 kywslyefih fiylytpida flnflpftsl lmsfgsiclt relvydfiaf mesqnkltgf 121 lnkitepnfn syllfssiyn iwfaddtndk flfgkltqil isvtkryefp rtfylakvsd 181 flqnliltrl rpfvteqpqg dknryqngdr estkngaayq kssqqsssfe qnftstefpn 241 dydfmedild etteld // LOCUS NP_014796 1511 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette multidrug transporter PDR5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014796 VERSION NP_014796.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183572.3 REFERENCE 1 (residues 1 to 1511) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1511) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1511) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1511) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10926. On Jul 30, 2012 this sequence version replaced NP_014796.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1511 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1511 /product="ATP-binding cassette multidrug transporter PDR5" /calculated_mol_wt="170308" Region 46..152 /region_name="ABC_trans_N" /note="ABC-transporter N-terminal; pfam14510" /db_xref="CDD:464194" Region 100..1503 /region_name="3a01205" /note="Pleiotropic Drug Resistance (PDR) Family protein; TIGR00956" /db_xref="CDD:273362" CDS 1..1511 /gene="PDR5" /locus_tag="YOR153W" /gene_synonym="LEM1; STS1; YDR1" /coded_by="NM_001183572.3:1..4536" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340|PMID:8810273]" /experiment="EXISTENCE:direct assay:GO:0008559 ABC-type xenobiotic transporter activity [PMID:21207971]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0030003 intracellular monoatomic cation homeostasis [PMID:8985171]" /experiment="EXISTENCE:mutant phenotype:GO:0008559 ABC-type xenobiotic transporter activity [PMID:15707993]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:17881724]" /experiment="EXISTENCE:mutant phenotype:GO:0030003 intracellular monoatomic cation homeostasis [PMID:8985171]" /experiment="EXISTENCE:mutant phenotype:GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane [PMID:9450972]" /note="Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication" /db_xref="GeneID:854324" /db_xref="SGD:S000005679" ORIGIN 1 mpeaklnnnv ndvtsyssas sstenaadlh nyngfdehte ariqklartl taqsmqnstq 61 sapnksdaqs ifssgvegvn pifsdpeapg ydpkldpnse nfssaawvkn mahlsaadpd 121 fykpyslgca wknlsasgas advayqstvv nipykilksg lrkfqrsket ntfqilkpmd 181 gclnpgellv vlgrpgsgct tllksissnt hgfdlgadtk isysgysgdd ikkhfrgevv 241 ynaeadvhlp hltvfetlvt varlktpqnr ikgvdresya nhlaevamat yglshtrntk 301 vgndivrgvs ggerkrvsia evsicgskfq cwdnatrgld satalefira lktqadisnt 361 satvaiyqcs qdaydlfnkv cvlddgyqiy ygpadkakky fedmgyvcps rqttadflts 421 vtspsertln kdmlkkgihi pqtpkemndy wvkspnykel mkevdqrlln ddeasreaik 481 eahiakqskr arpsspytvs ymmqvkylli rnmwrlrnni gftlfmilgn csmalilgsm 541 ffkimkkgdt stfyfrgsam ffailfnafs slleifslye arpitekhrt yslyhpsada 601 fasvlseips kliiavcfni ifyflvdfrr nggvfffyll inivavfsms hlfrcvgslt 661 ktlseamvpa smlllalsmy tgfaipkkki lrwskwiwyi nplaylfesl linefhgikf 721 pcaeyvprgp ayanisstes vctvvgavpg qdyvlgddfi rgtyqyyhkd kwrgfgigma 781 yvvffffvyl flceynegak qkgeilvfpr sivkrmkkrg vlteknandp envgersdls 841 sdrkmlqess eeesdtygei glskseaifh wrnlcyevqi kaetrrilnn vdgwvkpgtl 901 talmgasgag kttlldclae rvtmgvitgd ilvngiprdk sfprsigycq qqdlhlktat 961 vreslrfsay lrqpaevsie eknryveevi kilemekyad avvgvagegl nveqrkrlti 1021 gveltakpkl lvfldeptsg ldsqtawsic qlmkklanhg qailctihqp sailmqefdr 1081 llfmqrggkt vyfgdlgegc ktmidyfesh gahkcpadan paewmlevvg aapgshanqd 1141 yyevwrnsee yravqseldw merelpkkgs itaaedkhef sqsiiyqtkl vsirlfqqyw 1201 rspdylwskf iltifnqlfi gftffkagts lqglqnqmla vfmftvifnp ilqqylpsfv 1261 qqrdlyeare rpsrtfswis fifaqifvev pwnilagtia yfiyyypigf ysnasaagql 1321 hergalfwlf scafyvyvgs mgllvisfnq vaesaanlas llftmslsfc gvmttpsamp 1381 rfwifmyrvs pltyfiqall avgvanvdvk cadyelleft ppsgmtcgqy mepylqlakt 1441 gyltdenatd tcsfcqistt ndylanvnsf yserwrnygi ficyiafnyi agvffywlar 1501 vpkkngklsk k // LOCUS NP_014797 587 aa linear PLN 30-JUN-2025 DEFINITION Slp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014797 VERSION NP_014797.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183573.1 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10927. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..587 /product="Slp1p" /calculated_mol_wt="67321" Region 204..330 /region_name="Sad1_UNC" /note="Sad1 / UNC-like C-terminal; pfam07738" /db_xref="CDD:400199" CDS 1..587 /gene="SLP1" /locus_tag="YOR154W" /coded_by="NM_001183573.1:1..1764" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:23275891]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0034975 protein folding in endoplasmic reticulum [PMID:19325107]" /note="Glycosylated integral ER membrane hypothetical protein; forms an ER-membrane associated protein complex with Emp65p; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins; required for nuclear envelope localization of Mps3p" /db_xref="GeneID:854325" /db_xref="SGD:S000005680" ORIGIN 1 manrlliygl ilwvsiigsf aldrnktaqn akiglhdttv ittgsttnvq kehssplstg 61 slrthdfrqa skvdirqadi rengerkeqd altqpatprn pgdssnsfls fdewkkvksk 121 ehssgperhl srvrepvdps cykekecige eleidlgflt nknewseree nqkgfneekd 181 iekvykkkfn yasldcaati vksnpeaiga tstlieskdk yllnpcsapq qfivielced 241 ilveeieian yeffsstfkr frvsvsdrip mvknewtilg efearnsrel qkfqihnpqi 301 wasylkieil shyedefycp islikvygks mmdefkidql kaqedkeqsi gtnninnlne 361 qniqdrcnni etrletpnts nlsdlagals ctskliplkf deffkvlnas fcpskqmiss 421 ssssavpvip eesifknimk rlsqletnss ltvsyieeqs kllsksfeql emaheakfsh 481 lvtifnetmm snldllnnfa nqlkdqslri leeqklendk ftnrhllhle rlekevsfqr 541 rivyasffaf vglisyllit relyfedfee skngaiekad ivqqair // LOCUS NP_014798 450 aa linear PLN 30-JUN-2025 DEFINITION IMP 5'-nucleotidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014798 VERSION NP_014798.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183574.3 REFERENCE 1 (residues 1 to 450) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 450) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 450) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 450) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 450) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10928. On Jul 30, 2012 this sequence version replaced NP_014798.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..450 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..450 /product="IMP 5'-nucleotidase" /EC_number="3.1.3.99" /calculated_mol_wt="51199" Region 1..443 /region_name="ISN1" /note="IMP-specific 5'-nucleotidase; pfam06437" /db_xref="CDD:428942" CDS 1..450 /gene="ISN1" /locus_tag="YOR155C" /coded_by="NM_001183574.3:1..1353" /experiment="EXISTENCE:direct assay:GO:0008253 5'-nucleotidase activity [PMID:12735798]" /experiment="EXISTENCE:genetic interaction:GO:0071590 nicotinamide riboside biosynthetic process [PMID:19846558]" /experiment="EXISTENCE:genetic interaction:GO:0071592 nicotinic acid riboside biosynthetic process [PMID:19846558]" /experiment="EXISTENCE:mutant phenotype:GO:0006190 inosine salvage [PMID:12735798]" /experiment="EXISTENCE:mutant phenotype:GO:0071590 nicotinamide riboside biosynthetic process [PMID:19846558]" /experiment="EXISTENCE:mutant phenotype:GO:0071592 nicotinic acid riboside biosynthetic process [PMID:19846558]" /note="Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase; catalyzes the breakdown of IMP to inosine; responsible for production of nicotinamide riboside and nicotinic acid riboside; tetrameric form negatively regulated by inosine and ATP; expression positively regulated by nicotinic acid and glucose availability; does not show similarity to known 5'-nucleotidases from other organisms" /db_xref="GeneID:854326" /db_xref="SGD:S000005681" ORIGIN 1 mssryrveyh lkshrkdefi dwvkgllasp fvlhavsheg dynddlattq rvrsqyadif 61 kdieglikdk iefdsrnmsq deiedgassq slnilgqsrl nllvpsigtf ftelpleqaf 121 lwedsqrais arrmvapsfn dirhilntaq ifhfkkqenl hngkvlrlvt fdgdvtlyed 181 ggslvytnpv ipyilkllrc ginvgivtaa gydeagtyen rlkglivalh dstdipvsqk 241 qnltimgges sylfryyedp eednfgfrqi dkeewllprm kawsledvek tldfaertln 301 rlrkrlnlps eisiirkvra vgivpgeryd easkrqvpvk ldreqleeiv ltlqntlesf 361 apsrriqfsc fdggsdvwcd iggkdlgvrs lqqfynpesp iqpsetlhvg dqfapvgsan 421 dfkarlagct lwiaspqetv nylhrlletd // LOCUS NP_014799 726 aa linear PLN 30-JUN-2025 DEFINITION SUMO ligase NFI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014799 VERSION NP_014799.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183575.1 REFERENCE 1 (residues 1 to 726) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 726) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 726) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 726) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 726) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10929. Method: conceptual translation. FEATURES Location/Qualifiers source 1..726 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..726 /product="SUMO ligase NFI1" /calculated_mol_wt="81047" Region 43..77 /region_name="SAP" /note="Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation; smart00513" /db_xref="CDD:128789" Region 156..289 /region_name="PINIT" /note="PINIT domain; pfam14324" /db_xref="CDD:464136" Region 331..386 /region_name="SP-RING_ScSiz-like" /note="SP-RING finger found in Saccharomyces cerevisiae E3 SUMO-protein ligase SIZ1, SIZ2, and similar proteins; cd16793" /db_xref="CDD:438447" Region 476..>703 /region_name="ROM1" /note="RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms]; COG5422" /db_xref="CDD:227709" CDS 1..726 /gene="NFI1" /locus_tag="YOR156C" /gene_synonym="SIZ2" /coded_by="NM_001183575.1:1..2181" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16204216]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:23122649]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:23443663|PMID:12761287]" /experiment="EXISTENCE:direct assay:GO:0019789 SUMO transferase activity [PMID:12761287]" /experiment="EXISTENCE:genetic interaction:GO:0016925 protein sumoylation [PMID:26960795]" /experiment="EXISTENCE:genetic interaction:GO:1990683 DNA double-strand break attachment to nuclear envelope [PMID:27056668]" /experiment="EXISTENCE:mutant phenotype:GO:0003690 double-stranded DNA binding [PMID:23122649]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16204216]" /experiment="EXISTENCE:mutant phenotype:GO:0016925 protein sumoylation [PMID:23122649|PMID:22345352]" /experiment="EXISTENCE:mutant phenotype:GO:0019789 SUMO transferase activity [PMID:23122649]" /note="SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; sumoylates Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; role in telomere length maintenance" /db_xref="GeneID:854327" /db_xref="SGD:S000005682" ORIGIN 1 masvmsnnnn nnnnnnasym ftnplsntgg glineikdai nemeqlkvle lkqicksldl 61 sitgkkavlq drikqflrks cdighidpwr pkaikiliak vrinsslpky stlwetlktg 121 afkhpvasgq lpvtalqsta lppysqqqal aysftspfyk pivqipdank klkqsagrgc 181 tkmkfkvsks nhdllksnks yklylfsgfs ipfiyetvgh eaidfpypce lvfngtkled 241 nvkglkkqng tgnpanltpy lkvptemnhl dlhylnidke ysiscfivev fspeallgki 301 lkrpkiikqa ttayikrtln eqddddiitt stvlslqcpi sctrmkypak tdqckhiqcf 361 dalwflhsqs qvptwqcpic qhpikfdqlk isefvdniiq ncnedveqve isvdgswkpi 421 hnssavitdt vnqnhsvkne nqgtvkqeqd ydsrnafdtn lrngsnhnep eiisldssdd 481 eafipasksf pthvnprndq lradifpses egssdynpnh tstpkgsptm dqdnyqdafq 541 mrsflnqgat tnindtptnn ssinsfvtat ngdsrifynr gpstpllpav lqnltnqtea 601 qrnpygpnyn ttaqdrnllg iegdlppipp vdpnseaete lptrttsaah lppyihvsts 661 ghgddgkirk rrhsnvsiyi pknpyatlmk rrpqanhaim nktlaqtndf ntsaqdnsev 721 vdltsd // LOCUS NP_014800 261 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit beta 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014800 VERSION NP_014800.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183576.3 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10930. On Jul 30, 2012 this sequence version replaced NP_014800.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..261 /product="proteasome core particle subunit beta 2" /EC_number="3.4.25.1" /calculated_mol_wt="28137" Region 30..219 /region_name="proteasome_beta_type_7" /note="proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03763" /db_xref="CDD:239732" Site order(30,46,48,62,158,195,198..199) /site_type="active" /db_xref="CDD:239732" Site order(48,51,53..58,78,80,95,107,110..111,113..114,117,120, 143,145,147..150,153,161..162,164..165,168..170,186, 193..196,199..200) /site_type="other" /note="beta subunit interaction site [polypeptide binding]" /db_xref="CDD:239732" Region 222..257 /region_name="Pr_beta_C" /note="Proteasome beta subunits C terminal; pfam12465" /db_xref="CDD:463597" CDS 1..261 /gene="PUP1" /locus_tag="YOR157C" /coded_by="NM_001183576.3:1..786" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18504300|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:19029916|PMID:11545745]" /experiment="EXISTENCE:mutant phenotype:GO:0004175 endopeptidase activity [PMID:9207060|PMID:9312134]" /note="Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z" /db_xref="GeneID:854328" /db_xref="SGD:S000005683" ORIGIN 1 maglsfdnyq rnnflaensh tqpkatstgt tivgvkfnng vviaadtrst qgpivadknc 61 aklhrispki wcagagtaad teavtqligs nielhslyts reprvvsalq mlkqhlfkyq 121 ghigayliva gvdptgshlf sihahgstdv gyylslgsgs laamavlesh wkqdltkeea 181 iklasdaiqa giwndlgsgs nvdvcvmeig kdaeylrnyl tpnvreekqk sykfprgtta 241 vlkesivnic diqeeqvdit a // LOCUS NP_014801 318 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein mS26 PET123 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014801 VERSION NP_014801.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183577.1 REFERENCE 1 (residues 1 to 318) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 318) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 318) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 318) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10931. Method: conceptual translation. FEATURES Location/Qualifiers source 1..318 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..318 /product="mitochondrial 37S ribosomal protein mS26 PET123" /calculated_mol_wt="35867" Region 9..224 /region_name="mS26_PET12" /note="Saccharomyces cerevisiae mitochondrial small ribosomal subunit protein mS26 and similar proteins; cd23703" /db_xref="CDD:467916" CDS 1..318 /gene="PET123" /locus_tag="YOR158W" /gene_synonym="mS26" /coded_by="NM_001183577.1:1..957" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator" /db_xref="GeneID:854329" /db_xref="SGD:S000005684" ORIGIN 1 mgkgaakygf ksgvfpttrs ilkspttkqt diinkvkspk pkgvlgigya kgvkhpkgsh 61 rlspkvnfid vdnliaktva epqsikssng saqkvrlqka elrrkfliea frkeearllh 121 kheylqkrtk elekakelel eklnkekssd ltimtldkmm sqpllrnrsp eesellklkr 181 nynrsllnfq ahkkklnell nlyhvanefi vtesqllkki dkvfndetee ftdaydvtsn 241 ftqfgnrkll lsgnttlqtq innaimgsls nekffdislv dsylnkdlkn isnkidskln 301 ptsngagnng nnnnttnl // LOCUS NP_014802 94 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SME1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014802 VERSION NP_014802.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183578.3 REFERENCE 1 (residues 1 to 94) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 94) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 94) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 94) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 94) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10932. On Jul 30, 2012 this sequence version replaced NP_014802.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..94 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..94 /product="mRNA splicing protein SME1" /calculated_mol_wt="10244" Region 7..92 /region_name="Sm_E" /note="Sm protein E; cd01718" /db_xref="CDD:212465" Site order(20,32,34,37,44..47,51,59,75,77,79..83,86..92) /site_type="other" /note="heptamer interface [polypeptide binding]" /db_xref="CDD:212465" Site order(29..35,37..49,51..55) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212465" Site order(47,49..51,83,85) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:212465" Site 79..90 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212465" CDS 1..94 /gene="SME1" /locus_tag="YOR159C" /coded_by="NM_001183578.3:1..285" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284|PMID:11720285]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9012791|PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:8918241]" /experiment="EXISTENCE:physical interaction:GO:1990935 splicing factor binding [PMID:9528767]" /note="Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E" /db_xref="GeneID:854330" /db_xref="SGD:S000005685" ORIGIN 1 msnkvktkam vppincifnf lqqqtpvtiw lfeqigirik gkivgfdefm nvvideavei 61 pvnsadgked vekgtplgki llkgdnitli tsad // LOCUS NP_014803 972 aa linear PLN 30-JUN-2025 DEFINITION mRNA transport regulator MTR10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014803 VERSION NP_014803.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183579.1 REFERENCE 1 (residues 1 to 972) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 972) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 972) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 972) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 972) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 972) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 972) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 972) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 972) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10933. Method: conceptual translation. FEATURES Location/Qualifiers source 1..972 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..972 /product="mRNA transport regulator MTR10" /calculated_mol_wt="110615" Region 28..97 /region_name="IBN_N" /note="Importin-beta N-terminal domain; smart00913" /db_xref="CDD:197981" Region 100..253 /region_name="Xpo1" /note="Exportin 1-like protein; pfam08389" /db_xref="CDD:462459" CDS 1..972 /gene="MTR10" /locus_tag="YOR160W" /gene_synonym="KAP111" /coded_by="NM_001183579.1:1..2919" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9545233]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9412460|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:9545233|PMID:9412460]" /experiment="EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:9545233]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /experiment="EXISTENCE:mutant phenotype:GO:0006403 RNA localization [PMID:12167699]" /experiment="EXISTENCE:mutant phenotype:GO:0006404 RNA import into nucleus [PMID:17409072|PMID:16040803]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:9545233|PMID:9412460]" /experiment="EXISTENCE:mutant phenotype:GO:0035719 tRNA import into nucleus [PMID:33074312]" /experiment="EXISTENCE:mutant phenotype:GO:0051031 tRNA transport [PMID:17409072|PMID:20032305]" /experiment="EXISTENCE:mutant phenotype:GO:0061015 snRNA import into nucleus [PMID:31189105]" /note="Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress" /db_xref="GeneID:854331" /db_xref="SGD:S000005686" ORIGIN 1 mdnlqvsdie talqcissta sqddknkalq fleqfqrstv awsicneils kedptnalle 61 lnifaaqtlr nkvtydlsql ennlpqfkds lltlllshnq kliitqlnva larlaiqfle 121 wqnpifeiis llnsspsill nflrilpeet ldiastslte vefnsrihel idpiaedvlk 181 flvscidllq ntdgnssssi sleqilrcln swsyefpveq lltvqplinl vfetisngne 241 sdmeafdsai dclcvilres rdttneqlis alfhqlmllq ekllptlftd hplndeyddd 301 llegmtrlfv eageawsvvi sknpdffkpm vlvllmltck nedldvvsyt fpfwfnfkqs 361 lvlpryqesr kaysdifvkl ingiithlqy psgqfsskee edkfkdfryh mgdvlkdcta 421 vvgtsealsq pliriksaie nnnswqimea plfslrtmak eisltentil peiikiicnl 481 peqakiryas tlvlgrytew takhpellev qlqyifngfq lhegssdmqs iitasshalm 541 ffcsdcskll vgyidqlinf flnvqssidi esqfelcqgl savinnqpea kvsvifqklv 601 ddnlrqieal ipqwkanptl lapqiadkid llyalfeelk prynypqqgs epllpriefi 661 wkalrtllvd agamtdsiiv ervakllrri ferfhvfcep ilpsvaefli qgylttgfgs 721 ylwcsgsliv ifgddesfpi spslkdavwk falsqcetfi lnfnkfdklq lndyheaiid 781 ffslisdlim fypgaflnst ellgpvlnva lecvnkldny dayicilrcl ddiiswgfkt 841 ppistvsiei vpdewrkqvi nevviahgnq lilvlfiglv ttfentahsd aiscivkclr 901 ilteannnda ticidwiykv veqlgqvtln erdnlakavv eglnskdyrk vregirafvg 961 wysrkninsr fe // LOCUS NP_014804 539 aa linear PLN 30-JUN-2025 DEFINITION Pns1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014804 VERSION NP_014804.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183580.3 REFERENCE 1 (residues 1 to 539) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 539) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 539) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 539) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 539) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10934. On Jul 30, 2012 this sequence version replaced NP_014804.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..539 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..539 /product="Pns1p" /calculated_mol_wt="60120" Region 187..510 /region_name="Choline_transpo" /note="Plasma-membrane choline transporter; pfam04515" /db_xref="CDD:461337" CDS 1..539 /gene="PNS1" /locus_tag="YOR161C" /coded_by="NM_001183580.3:1..1620" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport" /db_xref="GeneID:854332" /db_xref="SGD:S000005687" ORIGIN 1 mplnekyerp pqpppaydpn hrppsssens aaanvndgqt pyhfrqdqyy nlnsktsgap 61 igsfdeafpt endnkprwnd wpftifflct vggfiaiaai tlrawsqtys stgsgiydgv 121 ntgtlntnaa illvfvciia lvfsvlgltl crifpkqfiy cgmvinlvas lgtaimymsl 181 rywsagivfl vftfmtawcy wgmrsripls vavlkvvvda mkkcpqiffv sfvgalvasa 241 fgflfsaviv atyikydpns snggcdvsgg scshskligv lvvvffcgyy isevirnvih 301 cvisgvfgsw yymsksdqgm prwpafgalk ramtysfgsi cfgsllvali dllrqilqmi 361 rhdvtssggg qiaiqilfmv fdwiigflkw laeyfnhyay sfialygkpy lraaketwym 421 lrekgmdali ndnlinialg lfsmfasymt alftflylrf tspqynsnga yngalmafsf 481 vialqicnia teairsgtat ffvalgndpe vfhhsyphrf deifraypdv lrklshqnv // LOCUS NP_878172 48 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR161C-C [Saccharomyces cerevisiae S288C]. ACCESSION NP_878172 VERSION NP_878172.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184625.1 REFERENCE 1 (residues 1 to 48) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 48) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 48) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 48) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 48) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 48) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 48) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 48) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 48) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10935. Method: conceptual translation. FEATURES Location/Qualifiers source 1..48 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..48 /product="uncharacterized protein" /calculated_mol_wt="5297" CDS 1..48 /locus_tag="YOR161C-C" /coded_by="NM_001184625.1:1..147" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466484" /db_xref="SGD:S000028712" ORIGIN 1 msytrvdhpt gkmachlrqi lasplffany vlhaaihyps sdirgdil // LOCUS NP_014805 810 aa linear PLN 30-JUN-2025 DEFINITION Yrr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014805 VERSION NP_014805.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183581.3 REFERENCE 1 (residues 1 to 810) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 810) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 810) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 810) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10936. On Jul 30, 2012 this sequence version replaced NP_014805.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..810 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..810 /product="Yrr1p" /calculated_mol_wt="92337" Region 49..84 /region_name="GAL4" /note="GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6)motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations; cd00067" /db_xref="CDD:238023" Site order(49,53,58..61,63,66,76) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(54,57,64,71,74,82) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..810 /gene="YRR1" /locus_tag="YOR162C" /gene_synonym="PDR2" /coded_by="NM_001183581.3:1..2433" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:11909958]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:11134057|PMID:10052137]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9767597]" /experiment="EXISTENCE:direct assay:GO:0034599 cellular response to oxidative stress [PMID:9767597]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11134057]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9767597]" /experiment="EXISTENCE:genetic interaction:GO:0034599 cellular response to oxidative stress [PMID:9767597]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:10052137]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9767597]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:9767597]" /note="Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication" /db_xref="GeneID:854333" /db_xref="SGD:S000005688" ORIGIN 1 mkrrsdallg sfqatnvtpp sdnsnstagg angsnsgtpt stsgkkrnkl ikscgfcrrr 61 klrcdqqkpm cstcisrnlt tcqyaeefnk niekkatygp ypnadllkkv eelenkiril 121 eaekntnssa ssmytspnfp plgtsvgrgs tetssplpdg vinpyadryy lqskhsgrst 181 lygptsmrtq iansnwgfie kykqlwakvk vernkwkqnn qktmcrelgl ldesdwqpdp 241 likqicrflp synkalsild dffndgacne invildkakv rrdfldyfmp ekevkaegdr 301 sivyilsnpk knyykaavil lilclkyfht dvptpiekff tllkgastak vfyieraqml 361 ilfyyhrety sfggdgsdlv nineclvttv ttiglhlnir etfkehevfm gsieslenvw 421 lmaifidyni scnvgrplli nkfyldenqd hcilnskskt yegklkrylk ltrpmlltly 481 drdkfpdlka yskriinfve eelgplghyt geniseevpl resrilsmav glllsfyali 541 hsvlkvrnie sknntfqlvl infsiivntt ircyridkal ypekfeasnp hlpphmalsm 601 sltaglfskt lvffcsliyf kltlfenglc lsndmevgws dltkltvpld kdlslgtams 661 lyssifdrlf tvgnkelirt mhrssqfvie laiertyrti lgnviefrkl teetwlaqik 721 qeldpqsdnp sseakivsdr qrdlslavpt ptpsiipmlp spgetknhak sqseiiqmlt 781 defwanynsg weelinqsef stlfddykdn // LOCUS NP_014806 188 aa linear PLN 30-JUN-2025 DEFINITION polyphosphatase DDP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014806 VERSION NP_014806.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183582.1 REFERENCE 1 (residues 1 to 188) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 188) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 188) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 188) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10937. Method: conceptual translation. FEATURES Location/Qualifiers source 1..188 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..188 /product="polyphosphatase DDP1" /EC_number="3.6.1.52" /EC_number="3.6.1.60" /EC_number="3.6.1.10" /calculated_mol_wt="21441" Region 33..181 /region_name="NUDIX_DIPP2_like_Nudt4" /note="diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase type 2 and similar proteins; cd04666" /db_xref="CDD:467551" CDS 1..188 /gene="DDP1" /locus_tag="YOR163W" /coded_by="NM_001183582.1:1..567" /experiment="EXISTENCE:direct assay:GO:0000298 endopolyphosphatase activity [PMID:31175919|PMID:21775424]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006798 polyphosphate catabolic process [PMID:21775424]" /experiment="EXISTENCE:direct assay:GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity [PMID:10419486]" /experiment="EXISTENCE:direct assay:GO:0015961 diadenosine polyphosphate catabolic process [PMID:9450008|PMID:10085096]" /experiment="EXISTENCE:direct assay:GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity [PMID:10085096|PMID:9450008]" /experiment="EXISTENCE:direct assay:GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity [PMID:10085096|PMID:9450008]" /experiment="EXISTENCE:direct assay:GO:1990174 phosphodiesterase decapping endonuclease activity [PMID:23353937]" /note="Diadenosine and diphosphoinositol polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854334" /db_xref="SGD:S000005689" ORIGIN 1 mgktadnhgp vrsetaregr enqvyspvtg arlvagcicl tpdkkqvlmi tssahkkrwi 61 vpkggvekde pnyettaqre tweeagcigk ivanlgtved mrppkdwnkd ikqfensrkd 121 sevakhpprt efhfyeleie nlldkfpech krhrklysyt eakqnlidak rpellealnr 181 saiikddk // LOCUS NP_014807 312 aa linear PLN 30-JUN-2025 DEFINITION protein GET4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014807 VERSION NP_014807.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183583.3 REFERENCE 1 (residues 1 to 312) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 312) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 312) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 312) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 312) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10938. On Jul 30, 2012 this sequence version replaced NP_014807.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..312 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..312 /product="protein GET4" /calculated_mol_wt="36149" Region 46..308 /region_name="GET4" /note="Golgi to ER traffic protein 4; pfam04190" /db_xref="CDD:461217" CDS 1..312 /gene="GET4" /locus_tag="YOR164C" /gene_synonym="ENV8" /coded_by="NM_001183583.3:1..939" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:20850366]" /experiment="EXISTENCE:direct assay:GO:0072380 TRC complex [PMID:20850366]" /experiment="EXISTENCE:genetic interaction:GO:0045048 protein insertion into ER membrane [PMID:19325107]" /note="Protein involved in inserting tail-anchored proteins into ER membranes; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20" /db_xref="GeneID:854335" /db_xref="SGD:S000005690" ORIGIN 1 mvpaesnavq aklaktlqrf enkikagdyy eahqtlrtia nryvrsksye haielisqga 61 lsflkakqgg sgtdlifyll evydlaevkv ddisvarlvr liaeldpsep nlkdvitgmn 121 nwsikfseyk fgdpylhnti gskllegdfv yeaeryfmlg thdsmikyvd llwdwlcqvd 181 diedstvaef fsrlvfnylf isnisfahes kdiflerfie kfhpkyekid kngyeivffe 241 dysdlnflql llitcqtkdk syflnlknhy ldfsqaykse leflgqeyfn ivapkqtnfl 301 qdmmsgflgg sk // LOCUS NP_014808 776 aa linear PLN 30-JUN-2025 DEFINITION dynamin-like GTPase SEY1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014808 VERSION NP_014808.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183584.1 REFERENCE 1 (residues 1 to 776) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 776) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 776) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 776) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 776) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 776) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 776) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 776) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 776) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10939. Method: conceptual translation. FEATURES Location/Qualifiers source 1..776 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..776 /product="dynamin-like GTPase SEY1" /calculated_mol_wt="89302" Region 43..292 /region_name="RHD3_GTPase" /note="Root hair defective 3 GTP-binding protein (RHD3) GTPase domain; pfam05879" /db_xref="CDD:461768" Region 330..740 /region_name="Sey1_3HB" /note="Sey1 three-helix bundle domain; pfam20428" /db_xref="CDD:466577" CDS 1..776 /gene="SEY1" /locus_tag="YOR165W" /coded_by="NM_001183584.1:1..2331" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:19665976]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016320 endoplasmic reticulum membrane fusion [PMID:22508509]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:19665976]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0007029 endoplasmic reticulum organization [PMID:19665976|PMID:22508509]" /experiment="EXISTENCE:genetic interaction:GO:0016320 endoplasmic reticulum membrane fusion [PMID:22508509]" /experiment="EXISTENCE:genetic interaction:GO:0061024 membrane organization [PMID:12427979]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:19665976]" /experiment="EXISTENCE:mutant phenotype:GO:0016320 endoplasmic reticulum membrane fusion [PMID:22508509]" /note="Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3" /db_xref="GeneID:854336" /db_xref="SGD:S000005691" ORIGIN 1 madrpaiqli deekefhqsa lqyfqqcign rdvgldyhvi svfgsqssgk stllnvlfnt 61 nfdtmdaqvk rqqttkgiwl ahtkqvntti eidndrpdif vldvegsdgs ergedqdfer 121 kaalfaiavs evlivnmweq qiglyqgnnm allktvfevn lslfgkndnd hkvlllfvir 181 dhvgvtplss lsdsvtrele kiwtelskpa gcegsslydy fdlkfvglah kllqedkftq 241 dvkklgdsfv mkgtenyyfk pqyhhrlpld gwtmyaencw dqiernkdld lptqqilvar 301 fkteeisnea leefiskyde siaplkgnlg sltsqlvklk eecltkydeq asryarnvym 361 ekrealntkl nshisgtine fleslmeklw ddlklevssr dkattsfves vaagkskiek 421 efnesmetfk klgllisnee itckfsddie erikqlrdae lkakigrikk nlvpelkdhv 481 ihllshpskk vwddimndfe stikdnisay qvekdkydfk iglsesenak iyknirilaw 541 rtldttvhdy lkidtivsil rdrfedvfry daegsprlwk teeeidgafr vakehalevf 601 evlslavtsd nveiipdvpm aeeesgedne iyrdnegvfh srrfahilte lqkenvldqf 661 rrqinitvld skrsiittrt hippwiyvll avlgwnefva virnplfvtl tlilgatffv 721 ihkfglwgpv vnvvqsavge trtaikdklr qfvvedhevk esfemkdfsk neqkek // LOCUS NP_014809 458 aa linear PLN 30-JUN-2025 DEFINITION mRNA-processing endoribonuclease [Saccharomyces cerevisiae S288C]. ACCESSION NP_014809 VERSION NP_014809.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183585.3 REFERENCE 1 (residues 1 to 458) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 458) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 458) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 458) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10940. On Jul 30, 2012 this sequence version replaced NP_014809.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..458 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..458 /product="mRNA-processing endoribonuclease" /calculated_mol_wt="52243" Region 133..280 /region_name="PIN_Swt1-like" /note="VapC-like PIN domain of Saccharomyces cerevisiae Swt1p, human SWT1 and related proteins; cd18727" /db_xref="CDD:350294" CDS 1..458 /gene="SWT1" /locus_tag="YOR166C" /coded_by="NM_001183585.3:1..1377" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:19127978]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19127978|PMID:17030511]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19127978]" /experiment="EXISTENCE:mutant phenotype:GO:0004521 RNA endonuclease activity [PMID:19127978]" /experiment="EXISTENCE:mutant phenotype:GO:0071032 nuclear mRNA surveillance of mRNP export [PMID:19127978]" /note="RNA endoribonuclease involved in perinuclear mRNP quality control; involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain" /db_xref="GeneID:854337" /db_xref="SGD:S000005692" ORIGIN 1 mtdekrafpk gnnhirsetf ngsvshkise sikdiaslrp hgkytvqdid niiastsshe 61 nrgqsgdsng cinhdeegdi pmcdlndesd vemiseylss qremeaqsva nympkinddl 121 pllnpptlkt afvvdtnfii shlntleklr slsstyhhli ivpttviqel dglkkspdia 181 rdnddttnqe hdrtigtlar wgndwiyknl anldsgligq klkqslnpgs lkddsildcc 241 lyfkeilncf villsndknl ctkaltedil tvsfrknmda kiiamrayee nqlrfanlrd 301 stvnnfdqnv tsyahipgie tpplqfdkvs qnvfeqvket iffaidhtlr keygedigfi 361 dynpdkltti enasnyiylf wvsvfselft cskikknewk slptvlkskp tnlndlrtfe 421 qfwetvlhfl fskftneekq slekqihewk tsinaist // LOCUS NP_014810 67 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS28 RPS28A [Saccharomyces cerevisiae S288C]. ACCESSION NP_014810 VERSION NP_014810.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183586.1 REFERENCE 1 (residues 1 to 67) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 67) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 67) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 67) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10941. Method: conceptual translation. FEATURES Location/Qualifiers source 1..67 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..67 /product="40S ribosomal protein eS28 RPS28A" /calculated_mol_wt="7461" Region 8..67 /region_name="S1_S28E" /note="S28E, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. S28E protein is a component of the 30S ribosomal subunit. S28E is highly conserved among archaea and eukaryotes. S28E may control...; cd04457" /db_xref="CDD:239904" Site order(13,29,41,43) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:239904" CDS 1..67 /gene="RPS28A" /locus_tag="YOR167C" /gene_synonym="RPS33A" /coded_by="NM_001183586.1:1..204" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:24492965]" /note="Protein component of the small (40S) ribosomal subunit; has an extraribosomal function in regulation of RPS28B, in which Rps28Ap binds to a decapping complex via Edc3p, which then binds to RPS28B mRNA leading to its decapping and degradation; homologous to mammalian ribosomal protein S28, no bacterial homolog; RPS28A has a paralog, RPS28B, that arose from the whole genome duplication" /db_xref="GeneID:854338" /db_xref="SGD:S000005693" ORIGIN 1 mdnktpvtla kvikvlgrtg srggvtqvrv efledtsrti vrnvkgpvre ndilvlmese 61 rearrlr // LOCUS NP_014811 809 aa linear PLN 30-JUN-2025 DEFINITION glutamine--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014811 VERSION NP_014811.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183587.3 REFERENCE 1 (residues 1 to 809) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 809) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 809) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 809) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10942. On Jul 30, 2012 this sequence version replaced NP_014811.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..809 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..809 /product="glutamine--tRNA ligase" /EC_number="6.1.1.18" /calculated_mol_wt="93002" Region 5..163 /region_name="tRNA_synt_1c_R1" /note="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1; pfam04558" /db_xref="CDD:461353" Region 166..244 /region_name="tRNA_synt_1c_R2" /note="Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2; pfam04557" /db_xref="CDD:461352" Region 252..807 /region_name="glnS" /note="glutaminyl-tRNA synthetase; TIGR00440" /db_xref="CDD:273079" CDS 1..809 /gene="GLN4" /locus_tag="YOR168W" /coded_by="NM_001183587.3:1..2430" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004819 glutamine-tRNA ligase activity [PMID:2991203]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15706032]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:15706032]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:mutant phenotype:GO:0006425 glutaminyl-tRNA aminoacylation [PMID:2991203]" /note="Glutamine tRNA synthetase; monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Gln); N-terminal domain proposed to be involved in enzyme-tRNA interactions" /db_xref="GeneID:854339" /db_xref="SGD:S000005694" ORIGIN 1 mssveeltql fsqvgfedkk vkeivknkkv sdslyklike tpsdyqwnks tralvhnlas 61 fvkgtdlpks elivngiing dlktslqvda afkyvkange astkmgmnen sgvgieited 121 qvrnyvmqyi qenkerilte ryklvpgifa dvknlkelkw adprsfkpii dqevlkllgp 181 kderdlikkk tknnekkktn sakkssdnsa ssgpkrtmfn egflgdlhkv genpqaypel 241 mkehlevtgg kvrtrfppep ngylhighsk aimvnfgyak yhngtcylrf ddtnpekeap 301 eyfesikrmv swlgfkpwki tyssdyfdel yrlaevlikn gkayvchcta eeikrgrgik 361 edgtpggery ackhrdqsie qnlqefrdmr dgkykpgeai lrmkqdlnsp spqmwdliay 421 rvlnaphprt gtkwriypty dfthclvdsm enithslctt efylsresye wlcdqvhvfr 481 paqreygrln itgtvlskrk iaqlvdekfv rgwddprlft leairrrgvp pgailsfint 541 lgvttsttni qvvrfesavr kyledttprl mfvldpvevv vdnlsddyee latipyrpgt 601 pefgertvpf tnkfyiersd fsenvddkef frltpnqpvg likvshtvsf kslekdeagk 661 iirihvnydn kveegskpkk pktyiqwvpi sskynsplrv tetrvynqlf ksenpsshpe 721 gflkdinpes evvykesvme hnfgdvvkns pwvvdsvkns efyveedkds kevcrfqamr 781 vgyftldkes ttskvilnri vslkdatsk // LOCUS NP_014814 624 aa linear PLN 30-JUN-2025 DEFINITION sphinganine kinase LCB4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014814 VERSION NP_014814.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183590.1 REFERENCE 1 (residues 1 to 624) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 624) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 624) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 624) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10943. Method: conceptual translation. FEATURES Location/Qualifiers source 1..624 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..624 /product="sphinganine kinase LCB4" /EC_number="2.7.1.91" /calculated_mol_wt="69508" Region <225..591 /region_name="PLN02958" /note="diacylglycerol kinase/D-erythro-sphingosine kinase" /db_xref="CDD:215517" CDS 1..624 /gene="LCB4" /locus_tag="YOR171C" /coded_by="NM_001183590.1:1..1875" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:12493772|PMID:16141212]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:12459470]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16141212]" /experiment="EXISTENCE:direct assay:GO:0006665 sphingolipid metabolic process [PMID:9677363]" /experiment="EXISTENCE:direct assay:GO:0008481 sphingosine kinase activity [PMID:9677363]" /experiment="EXISTENCE:direct assay:GO:0032541 cortical endoplasmic reticulum [PMID:17686782]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0019722 calcium-mediated signaling [PMID:11278643]" /note="Sphingoid long-chain base kinase; responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes; LCB4 has a paralog, LCB5, that arose from the whole genome duplication" /db_xref="GeneID:854342" /db_xref="SGD:S000005697" ORIGIN 1 mvvqkklrai ltdegvliks qshhmfnkhg qlrsgdslsl lsclsclddg tlssdggsfd 61 eddslellpl nttipfnril nakyvnvgqk gfnngkissn pfqtenlsss senddvenhs 121 lsndkapvse sqsfpkkdkw dtktntvkvs pddsqdnsps lgikdnqqli eltfavpkgh 181 dvipqkltll idhvsrksra ntgeenissg tveeileksy enskrnrsil viinphggkg 241 taknlfltka rpilvesgck ieiaytkyar haidiakdld iskydtiaca sgdgipyevi 301 nglyrrpdrv dafnklavtq lpcgsgnams ischwtnnps yaalclvksi etridlmccs 361 qpsymnewpr lsflsqtygv iaesdintef irwmgpvrfn lgvafniiqg kkypcevfvk 421 yaakskkelk vhflenkdkn kgcltfepnp spnsspdlls knninnstkd elspnflned 481 nfklkypmte pvprdwekmd seltdnltif ytgkmpyiak dtkffpaalp adgtidlvit 541 daripvtrmt pillsldkgs hvlepevihs kilaykiipk vesglfsvdg ekfpleplqv 601 eimpmlcktl lrngryidte fesm // LOCUS NP_014815 786 aa linear PLN 30-JUN-2025 DEFINITION Yrm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014815 VERSION NP_014815.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183591.3 REFERENCE 1 (residues 1 to 786) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 786) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 786) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 786) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 786) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 786) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 786) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 786) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 786) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10944. On Jul 30, 2012 this sequence version replaced NP_014815.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..786 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..786 /product="Yrm1p" /calculated_mol_wt="90954" Region 25..68 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(26,30,35..38,40,43,53) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(31,34,41,48,51,59) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region <307..579 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..786 /gene="YRM1" /locus_tag="YOR172W" /coded_by="NM_001183591.3:1..2361" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:14512416]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:14512416]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:14512416]" /note="Zinc finger transcription factor involved in multidrug resistance; Zn(2)-Cys(6) zinc finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes" /db_xref="GeneID:854343" /db_xref="SGD:S000005698" ORIGIN 1 mskrgslqdr aspseetvkk aqkrrkpiks cafcrkrklr cdqqkpmcst cktrgrsgcl 61 ytekfthkie tkelfgstpn iellkriedl ekrlddkelt ekdvalstsp frnpyanfyy 121 lqckgsgrri vygptslrth lsnddnrfvn tynqlwskvk iernrwkarh kwtmkpetql 181 legpplektg sdilqqvcnv lpsfeqsski itdffntele tnevsevldk tkiindftss 241 flpsdellpn gerriekllp stkknyykig vilmilcirh fykntpeeie kflimltgls 301 takvyfiera qflllkyyhr eliwacgdds hmislvdllc staimlglhl nireiyknqe 361 nivgsmesle nlwvwiilsd fnvslnigrc lainssyfqv decengerlp kntnnysstv 421 ffdqsnscmg klkrflrlar pmldqiydrs afpdlaenck klrnfvetef hpisyytdse 481 liskvplcei kvlaqvlnll ltfyslryli ykeksvvlen nilqtilvsf slvinttilc 541 fnldekhfpe ffdhncvhlp pfmalslvyt nflfprastg fcaflyhklt lfekgyylss 601 nikdqevtdw dlstlnipld kamnlltafk ihsdifakws ndnnkqlrii marsytfvin 661 ialesiyrav lekvikyrte ventwlqqlq delngsyslt dnvntpidps lsdlgvtsas 721 plagnspglp peevrnnsen ashnnetgpi etelaqtisn efwtaynlgw eelmsqpdyk 781 ylfdtq // LOCUS NP_014816 353 aa linear PLN 30-JUN-2025 DEFINITION 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014816 VERSION NP_014816.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183592.1 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10945. On Oct 10, 2006 this sequence version replaced NP_014816.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..353 /product="5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase" /calculated_mol_wt="40810" Region 3..329 /region_name="COG5075" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227407" CDS 1..353 /gene="DCS2" /locus_tag="YOR173W" /coded_by="NM_001183592.1:1..1062" /experiment="EXISTENCE:direct assay:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:16963086]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:16963086]" /experiment="EXISTENCE:direct assay:GO:0004857 enzyme inhibitor activity [PMID:16963086]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0009267 cellular response to starvation [PMID:15240832]" /note="m(7)GpppX pyrophosphatase regulator; non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; DCS2 has a paralog, DCS1, that arose from the whole genome duplication" /db_xref="GeneID:854344" /db_xref="SGD:S000005699" ORIGIN 1 mgsqdlasli grfkyvrvld snphtkvisl lgsidgkdav ltaekthfif detvrrpsqs 61 grstpiffhr eideysflng itdlkeltsn diyywglsvl kqhilhnpta kvnliwpasq 121 fhikgydqqd lhvvretpdm yrnivvpfiq emctsermkw vnnilyegae ddrvvykeys 181 srnkedgfvi lpdmkwdgin idslylvaiv yrddikslrd lnpnhrdwli rlnkkiktii 241 pqhydynvnp delrvfihyq psyyhfhvhi vnirhpgvge ergsgmtill edviealgfl 301 gpegymkktl tyvigenhdl wkkgfkeeve kqlkhdgiat spekgsgfnt nlg // LOCUS NP_014817 284 aa linear PLN 30-JUN-2025 DEFINITION Med4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014817 VERSION NP_014817.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183593.3 REFERENCE 1 (residues 1 to 284) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 284) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 284) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 284) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10946. On Jul 30, 2012 this sequence version replaced NP_014817.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..284 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..284 /product="Med4p" /calculated_mol_wt="32074" Region 67..>208 /region_name="Med4" /note="Vitamin-D-receptor interacting Mediator subunit 4; pfam10018" /db_xref="CDD:401849" CDS 1..284 /gene="MED4" /locus_tag="YOR174W" /coded_by="NM_001183593.3:1..855" /experiment="EXISTENCE:direct assay:GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:9420330]" /experiment="EXISTENCE:direct assay:GO:0034605 cellular response to heat [PMID:23447536]" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" /db_xref="GeneID:854345" /db_xref="SGD:S000005700" ORIGIN 1 msvqdtkave fsmghirsss vslvaeatsn tnsedklskv qlyedlcrye dtlsklvesv 61 drfkpnldia kdlirtdeal fenvkllaey dniyrnlqki dkdseeldsk trkileilne 121 chdelkalpm leqvefeknt ilqqrskins telldyatkl skftkipptf dkgavgpnnf 181 iwpaedalrr gmlamaslhs keltripgee veetevptvp psqseeqkgq makkegtpkt 241 dsfifdgtak evgdeadntk dkekeenndd aldldldlfd pddf // LOCUS NP_014818 619 aa linear PLN 30-JUN-2025 DEFINITION lysophospholipid acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014818 VERSION NP_014818.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183594.1 REFERENCE 1 (residues 1 to 619) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 619) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 619) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 619) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10947. Method: conceptual translation. FEATURES Location/Qualifiers source 1..619 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..619 /product="lysophospholipid acyltransferase" /EC_number="2.3.1.23" /EC_number="2.3.1.51" /EC_number="2.3.1.n6" /EC_number="2.3.1.n7" /calculated_mol_wt="72097" Region 1..563 /region_name="COG5202" /note="Predicted membrane protein [Function unknown]" /db_xref="CDD:227529" CDS 1..619 /gene="ALE1" /locus_tag="YOR175C" /gene_synonym="LCA1; LPT1; SLC4" /coded_by="NM_001183594.1:1..1860" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:17890783|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008374 O-acyltransferase activity [PMID:17890783]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:17652094|PMID:38297966]" /experiment="EXISTENCE:direct assay:GO:0071618 lysophosphatidylethanolamine acyltransferase activity [PMID:17652094]" /experiment="EXISTENCE:genetic interaction:GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity [PMID:17675291]" /experiment="EXISTENCE:genetic interaction:GO:0046474 glycerophospholipid biosynthetic process [PMID:17675291]" /experiment="EXISTENCE:genetic interaction:GO:0090640 phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine [PMID:30514764]" /experiment="EXISTENCE:mutant phenotype:GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity [PMID:17675291|PMID:17726007]" /experiment="EXISTENCE:mutant phenotype:GO:0006646 phosphatidylethanolamine biosynthetic process [PMID:17652094]" /experiment="EXISTENCE:mutant phenotype:GO:0008374 O-acyltransferase activity [PMID:17890783]" /experiment="EXISTENCE:mutant phenotype:GO:0036151 phosphatidylcholine acyl-chain remodeling [PMID:39730635]" /experiment="EXISTENCE:mutant phenotype:GO:0046474 glycerophospholipid biosynthetic process [PMID:17675291|PMID:17890783|PMID:17726007]" /experiment="EXISTENCE:mutant phenotype:GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity [PMID:17951629|PMID:17726007]" /experiment="EXISTENCE:mutant phenotype:GO:0071618 lysophosphatidylethanolamine acyltransferase activity [PMID:17652094]" /note="Broad-specificity lysophospholipid acyltransferase; major lysophosphatidylethanolamine acyltransferase that localizes to the mitochondria-associated ER membrane; member of the MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; capable of remodeling phosphatidylcholine containing VLC polyunsaturated fatty acids and involved in fatty acid exchange at the sn-2 position of mature glycerophospholipids" /db_xref="GeneID:854346" /db_xref="SGD:S000005701" ORIGIN 1 mynpvdavlt kiitnygids ftlryaicll gsfplnailk ripekriglk ccfiismsmf 61 ylfgvlnlvs gfrtlfistm ftylisrfyr skfmphlnfm fvmghlainh ihaqflneqt 121 qttvditssq mvlamkltsf awsyydgsct sesdfkdlte hqksravrgh ppllkflaya 181 ffystlltgp sfdyadfdsw lncemfrdlp eskkpmrrhh pgerrqipkn gklalwkvvq 241 glawmilstl gmkhfpvkyv ldkdgfptrs fifrihylfl lgfihrfkyy aawtisegsc 301 ilcglgyngy dsktqkirwd rvrnidiwtv etaqntreml eawnmntnkw lkysvylrvt 361 kkgkkpgfrs tlftfltsaf whgtrpgyyl tfatgalyqt cgkiyrrnfr piflredgvt 421 plpskkiydl vgiyaiklaf gymvqpfiil dlkpslmvwg svyfyvhiiv afsfflfrgp 481 yakqvteffk skqpkeifir kqkklekdis asspnlggil kakiehekgk taeeeemnlg 541 ippielekwd nakedwedfc kdykewrnkn gleieeenls kaferfkqef snaasgsger 601 vrkmsfsgys pkpiskkee // LOCUS NP_014819 393 aa linear PLN 30-JUN-2025 DEFINITION ferrochelatase HEM15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014819 VERSION NP_014819.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183595.3 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10948. On Jul 30, 2012 this sequence version replaced NP_014819.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..393 /product="ferrochelatase HEM15" /EC_number="4.98.1.1" /calculated_mol_wt="44465" Region 34..358 /region_name="hemH" /note="ferrochelatase; TIGR00109" /db_xref="CDD:272909" CDS 1..393 /gene="HEM15" /locus_tag="YOR176W" /coded_by="NM_001183595.3:1..1182" /experiment="EXISTENCE:direct assay:GO:0004325 ferrochelatase activity [PMID:1304908]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:7629135]" /experiment="EXISTENCE:mutant phenotype:GO:0004325 ferrochelatase activity [PMID:2185242]" /experiment="EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:7035824]" /note="Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid" /db_xref="GeneID:854347" /db_xref="SGD:S000005702" ORIGIN 1 mlsrtirtqg sflrrsqlti trsfsvtfnm qnaqkrsptg ivlmnmggps kveetydfly 61 qlfadndlip isakyqktia kyiakfrtpk iekqyreigg gspirkwsey qatevckild 121 ktcpetaphk pyvafryakp ltaetykqml kdgvkkavaf sqyphfsyst tgssinelwr 181 qikaldsers iswsvidrwp tneglikafs enitkklqef pqpvrdkvvl lfsahslpmd 241 vvntgdaypa evaatvynim qklkfknpyr lvwqsqvgpk pwlgaqtaei aeflgpkvdg 301 lmfipiafts dhietlheid lgvigeseyk dkfkrcesln gnqtfiegma dlvkshlqsn 361 qlysnqlpld falgksndpv kdlslvfgnh est // LOCUS NP_014820 464 aa linear PLN 30-JUN-2025 DEFINITION Mpc54p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014820 VERSION NP_014820.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183596.1 REFERENCE 1 (residues 1 to 464) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 464) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 464) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 464) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 464) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10949. Method: conceptual translation. FEATURES Location/Qualifiers source 1..464 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..464 /product="Mpc54p" /calculated_mol_wt="54227" Region <166..>338 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" CDS 1..464 /gene="MPC54" /locus_tag="YOR177C" /coded_by="NM_001183596.1:1..1395" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:12796288]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0035974 meiotic spindle pole body [PMID:10899120]" /experiment="EXISTENCE:genetic interaction:GO:0032120 ascospore-type prospore membrane formation [PMID:10899120]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:12796288]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:10899120]" /experiment="EXISTENCE:mutant phenotype:GO:0048278 vesicle docking [PMID:20826607]" /note="Component of the meiotic outer plaque; a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate" /db_xref="GeneID:854349" /db_xref="SGD:S000005703" ORIGIN 1 mpedtsysns fedyynnsha ispykdsfyk emtpskpnvr fgdddvnifd qrkkvneink 61 nntvkrsips sisttitpnk sslksprgkr asknsfdnet klesknetlk evndavnrcy 121 alcniptkhv sinsisdlaq tfetlavgit hetnrkaece rsknaidsly yheqlekkel 181 nekslqmaid hllkvtkqnl rqaddgnklk etealksfie eieevddnki sinslqqqll 241 eektannilr rdyyklqerg rrlchefqel qddyskqmkq keyevqklkn eikvllnmnd 301 nlkaekahys qkekqyfqky tyiekymnhv keeynrkede ckklnfiidk smkkiehler 361 slqtqftaqn sfstamiqee gpkdahlkdr yhkvkefmeq klqtskindp scseaealdn 421 vlcliessmk tldknskcyp iatkkcikyv tdsprlkene hvtn // LOCUS NP_014821 793 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase regulator GAC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014821 VERSION NP_014821.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183597.3 REFERENCE 1 (residues 1 to 793) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 793) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 793) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 793) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10950. On Jul 30, 2012 this sequence version replaced NP_014821.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..793 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..793 /product="protein phosphatase regulator GAC1" /calculated_mol_wt="88402" Region 237..359 /region_name="CBM_21" /note="Carbohydrate/starch-binding module (family 21); pfam03370" /db_xref="CDD:427265" CDS 1..793 /gene="GAC1" /locus_tag="YOR178C" /coded_by="NM_001183597.3:1..2382" /experiment="EXISTENCE:direct assay:GO:0000164 protein phosphatase type 1 complex [PMID:8289829]" /experiment="EXISTENCE:direct assay:GO:0031072 heat shock protein binding [PMID:10207049]" /experiment="EXISTENCE:genetic interaction:GO:0019888 protein phosphatase regulator activity [PMID:1310938]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:10072380]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:10207049]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:11459182]" /experiment="EXISTENCE:physical interaction:GO:0005977 glycogen metabolic process [PMID:8289829]" /experiment="EXISTENCE:physical interaction:GO:0051321 meiotic cell cycle [PMID:8754819]" /note="Regulatory subunit for Glc7p type-1 protein phosphatase (PP1); tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; GAC1 has a paralog, PIG1, that arose from the whole genome duplication" /db_xref="GeneID:854350" /db_xref="SGD:S000005704" ORIGIN 1 mviqtattls pakarpsfph ndliksmsds lisrpthppi rklksslkis hpepisrsks 61 eifctspekn vrfaielttv krfdknaeps sisnensptl spvdsntaad dvqlfnnedc 121 wfndsslvtn llknekkfry mnslnnmfkl dlydsededd idehinsqae ygytynslst 181 rgktsenksa tsslatqatn icdwklhctd lvpfkiappl ftktlsasdl qgqltkylng 241 qnvklhsltq lgddsskitg lvyvknlsfe kyleikftfn swrdihyvta nfnrtinsnv 301 defkftidln slkyillikr iitmekntss cplnielccr ydvnnetyyd nnngknyhlf 361 mttfkkgget kekipvvvep asqtdaamsp kemkarfvss nptlsrflpq srkfsedtdy 421 yntsplkhly hndttswvkp krlnvvldkl enatppppss alandtartg kitkdknnvl 481 apptasnsid lpilgsqhqs lysgsssyss ssssisssls fassnnsstn sssascsfpl 541 teldnfdyan lyepndtftt anlfnhslns lmpeistpsf fggfrnenti nnndsknlvt 601 sledsyedkq svitdttmde nnktstinns tdtlikpske ngtvkenkss anstsapsss 661 qnrastilnd hsngksdlky vnyqslldsh cfynhpsspn lqstsfssaa pfsgisqasd 721 ifdyenedsd snqiageidn nsfpphfyld eddksaclsd dalidhhrnt npfintfsss 781 ppilsqevdr wrl // LOCUS NP_014822 188 aa linear PLN 30-JUN-2025 DEFINITION cleavage polyadenylation factor subunit SYC1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014822 VERSION NP_014822.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183598.1 REFERENCE 1 (residues 1 to 188) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 188) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 188) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 188) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 188) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10951. Method: conceptual translation. FEATURES Location/Qualifiers source 1..188 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..188 /product="cleavage polyadenylation factor subunit SYC1" /calculated_mol_wt="20735" Region <28..186 /region_name="CPSF73-100_C" /note="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term; cl13209" /db_xref="CDD:472439" CDS 1..188 /gene="SYC1" /locus_tag="YOR179C" /coded_by="NM_001183598.1:1..567" /experiment="EXISTENCE:curator inference:GO:0003723 RNA binding [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:mutant phenotype:GO:0031441 negative regulation of mRNA 3'-end processing [PMID:16431986]" /note="Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication" /db_xref="GeneID:854351" /db_xref="SGD:S000005705" ORIGIN 1 mdlpkdksdr thqrinlnns gtdrtndlyl hivqtfgcie ttatenatkl lmlgdvevei 61 sassvsiewt qksmisqtia dsivimiigl casdknvlse selkernhnv wkiqelqnlf 121 reqfgdsfsi degigkkenv kngsvtigks katidfstmk lidcnsnplk grvesilsig 181 qklttplc // LOCUS NP_014823 271 aa linear PLN 30-JUN-2025 DEFINITION putative dodecenoyl-CoA isomerase DCI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014823 VERSION NP_014823.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183599.3 REFERENCE 1 (residues 1 to 271) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 271) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 271) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 271) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 271) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10952. On Jul 30, 2012 this sequence version replaced NP_014823.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..271 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..271 /product="putative dodecenoyl-CoA isomerase DCI1" /EC_number="5.3.3.21" /calculated_mol_wt="29927" Region 7..178 /region_name="crotonase-like" /note="Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; cd06558" /db_xref="CDD:119339" Site order(24,26,58,62..66,116,118..120,143..144,147) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:119339" Site order(64,120) /site_type="active" /note="oxyanion hole (OAH) forming residues [active]" /db_xref="CDD:119339" Site order(89,108,129..132,145..148,154,156..158,160..161, 166..167,169..170,172..173,176) /site_type="other" /note="trimer interface [polypeptide binding]" /db_xref="CDD:119339" CDS 1..271 /gene="DCI1" /locus_tag="YOR180C" /gene_synonym="ECI2" /coded_by="NM_001183599.3:1..816" /experiment="EXISTENCE:direct assay:GO:0004165 delta(3)-delta(2)-enoyl-CoA isomerase activity [PMID:10455114]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005782 peroxisomal matrix [PMID:10381339]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:10381339]" /note="Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed; DCI1 has a paralog, ECI1, that arose from the whole genome duplication" /db_xref="GeneID:854352" /db_xref="SGD:S000005706" ORIGIN 1 mssrvcyhin gpffiiklid pkhlnsltfe dfvyialllh kandidsvlf tvlqssgkyf 61 ssggkfsavn klndgdvtse vekvsklvsa isspnifvan afaihkkvlv cclngpaigl 121 saslvalcdi vysqndsvfl lfpfsnlgfv aevgtsvtlt qklginsane hmifstpvlf 181 keligtiitk nyqltntetf nekvlqdikq nleglypksv lgmkellhse mkqklikaqa 241 metngtlpfw asgepfkrfk qlqegnrrhk l // LOCUS NP_014824 633 aa linear PLN 30-JUN-2025 DEFINITION actin-binding protein LAS17 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014824 VERSION NP_014824.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183600.1 REFERENCE 1 (residues 1 to 633) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 633) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 633) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 633) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10953. Method: conceptual translation. FEATURES Location/Qualifiers source 1..633 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..633 /product="actin-binding protein LAS17" /calculated_mol_wt="67441" Region 23..123 /region_name="EVH1_WASP-like" /note="WASP family proteins EVH1 domain; cd01205" /db_xref="CDD:269916" Site order(23,25,30,34,51,53,60,62,64,78,90,98,104) /site_type="other" /note="WAS mutation hotspots" /db_xref="CDD:269916" Site order(32,34,41,93,95) /site_type="other" /note="proline-rich peptide binding site [polypeptide binding]" /db_xref="CDD:269916" CDS 1..633 /gene="LAS17" /locus_tag="YOR181W" /gene_synonym="BEE1" /coded_by="NM_001183600.1:1..1902" /experiment="EXISTENCE:direct assay:GO:0003779 actin binding [PMID:10512884|PMID:23290554]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0007015 actin filament organization [PMID:9214384]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:16824951|PMID:9024694|PMID:10512884]" /experiment="EXISTENCE:direct assay:GO:0032233 positive regulation of actin filament bundle assembly [PMID:19158382]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0045010 actin nucleation [PMID:23290554]" /experiment="EXISTENCE:direct assay:GO:0071933 Arp2/3 complex binding [PMID:10322115]" /experiment="EXISTENCE:direct assay:GO:0140224 SLAC complex [PMID:22973053]" /experiment="EXISTENCE:direct assay:GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation [PMID:10322115|PMID:12814545|PMID:16824951|PMID:22973053|P MID:12499356|PMID:11604421]" /experiment="EXISTENCE:genetic interaction:GO:0051666 actin cortical patch localization [PMID:18177206]" /experiment="EXISTENCE:mutant phenotype:GO:0003779 actin binding [PMID:27637067]" /experiment="EXISTENCE:mutant phenotype:GO:0030041 actin filament polymerization [PMID:27637067]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:18177206]" /experiment="EXISTENCE:physical interaction:GO:0003779 actin binding [PMID:23290554]" /experiment="EXISTENCE:physical interaction:GO:0140224 SLAC complex [PMID:22973053]" /note="Actin assembly factor; C-terminal WCA domain activates Arp2/3 complex-mediated nucleation of branched actin filaments, polyproline domain able to nucleate actin filaments in absence of Arp2/3; contains 3 binding sites for monomeric actin which overlap with SH3 binding sites; binding between SH3 and actin is competitive; mutants are defective in endocytosis, bud site selection, cytokinesis; human homolog WAS (Wiskott-Aldrich Syndrome) implicated in severe immunodeficiency" /db_xref="GeneID:854353" /db_xref="SGD:S000005707" ORIGIN 1 mgllnssdke iikralpkas nkiidvtvar lyiaypdkne wqytglsgal alvddlvgnt 61 fflklvding hrgviwdqel yvnfeyyqdr tffhtfemee cfagllfvdi neashflkrv 121 qkreryanrk tllnknaval tkkvreeqks qvvhgprges lidnqrkryn yedvdtiptt 181 khkapppppp taetfdsdqt ssfsdinstt asapttpapa lppaspevrk eethpkhslp 241 plpnqfaplp dppqhnsppq nnapsqpqsn pfpfpipeip stqsatnpfp fpvpqqqfnq 301 apsmgipqqn rplpqlpnrn nrpvpppppm rtttegsgvr lpappppprr gpappppphr 361 hvtsntlnsa ggnsllpqat grrgpapppp prasrptpnv tmqqnpqqyn nsnrpfgyqt 421 nsnmsspppp pvttfntltp qmtaatgqpa vplpqntqap sqatnvpvap ppppaslgqs 481 qipqsapsap ipptlpstts aapppppafl tqqpqsggap apppppqmpa tstsgggsfa 541 ettgdagrda llasirgagg igalrkvdks qldkpsvllq eargesaspp aaagnggtpg 601 gppasladal aaalnkrktk vgahddmdng ddw // LOCUS NP_014825 63 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS30 RPS30B [Saccharomyces cerevisiae S288C]. ACCESSION NP_014825 VERSION NP_014825.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183601.3 REFERENCE 1 (residues 1 to 63) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 63) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 63) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 63) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10954. On Jul 30, 2012 this sequence version replaced NP_014825.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..63 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..63 /product="40S ribosomal protein eS30 RPS30B" /calculated_mol_wt="6987" Region 3..60 /region_name="Ribosomal_S30" /note="Ribosomal protein S30; pfam04758" /db_xref="CDD:398432" CDS 1..63 /gene="RPS30B" /locus_tag="YOR182C" /coded_by="NM_001183601.3:1..192" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S30, no bacterial homolog; RPS30B has a paralog, RPS30A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854354" /db_xref="SGD:S000005708" ORIGIN 1 makvhgslar agkvksqtpk vektekpkkp kgraykrlly trrfvnvtlv ngkrrmnpgp 61 svq // LOCUS NP_014826 129 aa linear PLN 30-JUN-2025 DEFINITION Fyv12p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014826 VERSION NP_014826.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183602.1 REFERENCE 1 (residues 1 to 129) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 129) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 129) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 129) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 129) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10955. Method: conceptual translation. FEATURES Location/Qualifiers source 1..129 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..129 /product="Fyv12p" /calculated_mol_wt="14661" CDS 1..129 /gene="FYV12" /locus_tag="YOR183W" /coded_by="NM_001183602.1:1..390" /note="hypothetical protein; required for survival upon exposure to K1 killer toxin" /db_xref="GeneID:854355" /db_xref="SGD:S000005709" ORIGIN 1 mrllhhgeyg tkliggkcsi dgklghpcpl srrrkkhlre kemgpqyvrm ygpkrkaiir 61 tgnpddginl pdtgrgtlta atiwsrayhs nysylvrpkv vtlskhrelm ttfllyvlyv 121 ciyisafik // LOCUS NP_014827 395 aa linear PLN 30-JUN-2025 DEFINITION O-phospho-L-serine:2-oxoglutarate transaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014827 VERSION NP_014827.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183603.3 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10956. On Jul 30, 2012 this sequence version replaced NP_014827.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..395 /product="O-phospho-L-serine:2-oxoglutarate transaminase" /EC_number="2.6.1.52" /calculated_mol_wt="43285" Region 9..392 /region_name="PSAT_like" /note="Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; cd00611" /db_xref="CDD:99736" Site order(10,15..16,18,77..78,81,120,123..124,223,271..273) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:99736" Site order(13,80..81,113,170,194,217..218,361) /site_type="active" /note="substrate-cofactor binding pocket [active]" /db_xref="CDD:99736" Site order(79..81,113,170,194,196,217..218) /site_type="other" /note="pyridoxal 5'-phosphate binding site [chemical binding]" /db_xref="CDD:99736" Site 218 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:99736" CDS 1..395 /gene="SER1" /locus_tag="YOR184W" /gene_synonym="ADE9" /coded_by="NM_001183603.3:1..1188" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity [PMID:8017107]" /experiment="EXISTENCE:mutant phenotype:GO:0006564 L-serine biosynthetic process [PMID:1326413|PMID:8017107]" /experiment="EXISTENCE:mutant phenotype:GO:0009113 purine nucleobase biosynthetic process [PMID:10509016]" /note="3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854356" /db_xref="SGD:S000005710" ORIGIN 1 mslereepqh fgagpaqmpt pvlqqaakdl infndiglgi geishrskda tkviedskkh 61 liellnipdt hevfylqggg ttgfssvatn laaayvgkhg kiapagylvt gswsqksfee 121 akrlhvpaev ifnakdynng kfgkipdesl wedkikgkaf syvylcenet vhgvewpelp 181 kclvndpnie ivadlssdil srkidvsqyg vimagaqkni glagltlyii kksilknisg 241 asdetlhelg vpitpiafdy ptvvknnsay ntipiftlhv mdlvfqhilk kggveaqqae 301 neekakilye aldansdfyn vpvdpkcrsk mnvvftlkkd glddqflkea aarhltglkg 361 hrsvggfras iynalsvkav qnlvdfikef aekna // LOCUS NP_014828 220 aa linear PLN 30-JUN-2025 DEFINITION Ran GTPase GSP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014828 VERSION NP_014828.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183604.1 REFERENCE 1 (residues 1 to 220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 220) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10957. Method: conceptual translation. FEATURES Location/Qualifiers source 1..220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..220 /product="Ran GTPase GSP2" /calculated_mol_wt="24859" Region 5..217 /region_name="PTZ00132" /note="GTP-binding nuclear protein Ran; Provisional" /db_xref="CDD:240284" CDS 1..220 /gene="GSP2" /locus_tag="YOR185C" /gene_synonym="CNR2" /coded_by="NM_001183604.1:1..663" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006997 nucleus organization [PMID:8455603]" /note="GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication" /db_xref="GeneID:854357" /db_xref="SGD:S000005711" ORIGIN 1 msapaqnnae vptfklvlvg dggtgkttfv krhltgefek kyiatigvev hplsfytnfg 61 eikfdvwdta gqekfgglrd gyyinaqcai imfdvtsrit yknvpnwhrd lvrvcenipi 121 vlcgnkvdvk erkvkaktit fhrkknlqyy disaksnynf ekpflwlark lagnpqlefv 181 aspalappev qvdeqlmhqy qqemdqatal plpdeddadl // LOCUS NP_014829 144 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR186W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014829 VERSION NP_014829.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183605.3 REFERENCE 1 (residues 1 to 144) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 144) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 144) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 144) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 144) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10958. On Jul 30, 2012 this sequence version replaced NP_014829.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..144 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..144 /product="uncharacterized protein" /calculated_mol_wt="16048" CDS 1..144 /locus_tag="YOR186W" /coded_by="NM_001183605.3:1..435" /note="hypothetical protein; proper regulation of expression during heat stress is sphingolipid-dependent; mCherry fusion protein localizes to the vacuole; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication" /db_xref="GeneID:854358" /db_xref="SGD:S000005712" ORIGIN 1 mtlafttfai skinnsstne dskvmilcde hhpfekgyfk sairafgnsi klglmgnsrp 61 edaasifqdk niphdlttee frlqlvcmaf swfifglfia clllcitlvl tsrypgenen 121 katevvpssn iddeekqlsl sdmi // LOCUS NP_014830 437 aa linear PLN 30-JUN-2025 DEFINITION translation elongation factor Tu [Saccharomyces cerevisiae S288C]. ACCESSION NP_014830 VERSION NP_014830.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183606.1 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10959. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..437 /product="translation elongation factor Tu" /calculated_mol_wt="47841" Region 40..437 /region_name="TufA" /note="Translation elongation factor EF-Tu, a GTPase [Translation, ribosomal structure and biogenesis]; COG0050" /db_xref="CDD:439820" CDS 1..437 /gene="TUF1" /locus_tag="YOR187W" /coded_by="NM_001183606.1:1..1314" /experiment="EXISTENCE:direct assay:GO:0003746 translation elongation factor activity [PMID:3301847]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:3301847]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:16823961|PMID:24769239|PMID:23727608]" /experiment="EXISTENCE:direct assay:GO:0032543 mitochondrial translation [PMID:6353412]" /experiment="EXISTENCE:genetic interaction:GO:0032543 mitochondrial translation [PMID:16777356|PMID:15695360]" /experiment="EXISTENCE:mutant phenotype:GO:0070125 mitochondrial translational elongation [PMID:3905388]" /note="Mitochondrial translation elongation factor Tu (EF-Tu); involved in fundamental pathway of mtDNA homeostasis; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; rare mutations in human mitochondrial elongation factor Tu (EFTu) associated with severe lactic acidosis, rapidly progressive fatal encephalopathy, severe infantile macrocystic leukodystrophy with micropolygyria" /db_xref="GeneID:854359" /db_xref="SGD:S000005713" ORIGIN 1 msallprllt rtafkasgkl lrlssvisrt fsqtttsyaa afdrskphvn igtighvdhg 61 kttltaaitk tlaakgganf ldyaaidkap eerargitis tahveyetak rhyshvdcpg 121 hadyiknmit gaaqmdgaii vvaatdgqmp qtrehlllar qvgvqhivvf vnkvdtiddp 181 emlelvemem rellneygfd gdnapiimgs alcalegrqp eigeqaimkl ldavdeyipt 241 perdlnkpfl mpvedifsis grgtvvtgrv ergnlkkgee leivghnstp lkttvtgiem 301 frkeldsama gdnagvllrg irrdqlkrgm vlakpgtvka htkilaslyi lskeeggrhs 361 gfgenyrpqm firtadvtvv mrfpkevedh smqvmpgdnv emecdlihpt plevgqrfni 421 reggrtvgtg litriie // LOCUS NP_014831 1137 aa linear PLN 30-JUN-2025 DEFINITION Msb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014831 VERSION NP_014831.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183607.3 REFERENCE 1 (residues 1 to 1137) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1137) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1137) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1137) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1137) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10960. On Jul 30, 2012 this sequence version replaced NP_014831.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1137 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1137 /product="Msb1p" /calculated_mol_wt="129841" Region 68..472 /region_name="Msb1-Mug8_dom" /note="Meiotically up-regulated protein Msb1/Mug8 domain; pfam08101" /db_xref="CDD:429827" Region <820..>1043 /region_name="Atrophin-1" /note="Atrophin-1 family; pfam03154" /db_xref="CDD:460830" CDS 1..1137 /gene="MSB1" /locus_tag="YOR188W" /coded_by="NM_001183607.3:1..3414" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922]" /experiment="EXISTENCE:genetic interaction:GO:0030010 establishment of cell polarity [PMID:10679030]" /note="hypothetical protein; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress" /db_xref="GeneID:854360" /db_xref="SGD:S000005714" ORIGIN 1 mndmakplpt pptaeirksr snspkkaqkt nlspnknqnn eknvprsngr tknehnsmdd 61 eefeffhqfs rekvkgvihv itaelkekgp dveflmipfr peqtndkllt llnqlfplgn 121 gqpvnekkql rivskadvwt lfqclkyiwc rlpnseiigw ksylefkfre edkkfprksf 181 leimpqclas pnhasivydf fdliisissn srvnkmsark iskmcaiwaf skqipnsdiq 241 dydfesaamk sfapnnsiqd gldqwipasd amfhlllafl rsfvpqdles aklprtlksl 301 lfnnqypprk staytsetil tiplvtlktd vfsrkpwqll ercndlldfs dhdafeared 361 yallkslfrk kntvegisrk msqesrrlmk amstkhstfq pgwaprecie nishlkecie 421 vkrldiddyf iwtwlsslsf eqtsekkkif grsiilefef dgfkkwvvfq ecditldynk 481 kgqlkkktsa qspttekelp pddfeledpp lsksptlsqt ykkfqaevpq qstvrrdsap 541 dnqgiyhtvi sknaltknkh nvnlhsfehk iskwnplnnl rkksgsnsss ssfeekskda 601 pireeyhtnk nhkskkeerv lsqfstlnpd eyqlpvietg ssnfkieipe lmyehdddds 661 dklknsqkra tdsaieelng mveemminep ddvkisitea etfesltkfd qykpsnitdd 721 dlqsshssav hslklstntn dscadsskyt adrklaeprk iseeskvndd sssyyspnin 781 nlpasrmpsq ptysnsdskk aftnesrlnv lqgavspsqq vtpkpyknap gdcvspvqqk 841 yyqndrrnem spasapvpps aysparspqf stnsagfkqn tinvpvgynd pahvlanqph 901 mtyrdqhnyp shqqkqrpfq nnivppelks rnqradaspi pqhmvpvkqg vpnlpsnvpl 961 yqqmermnpn hqhpvntykv tqppyhnntt naygnsragn ahmldgkwsn nppqmvpkgv 1021 rpnqypqqhv nryspqaqpv vpaeyyngpp pmrappmmsh mvpaqepiry taganrrsfp 1081 qgmqqnaysv paqpmgavns efylpeapqg nklhgninkr qerkklydni rsgnfgi // LOCUS NP_014832 116 aa linear PLN 30-JUN-2025 DEFINITION Ies4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014832 VERSION NP_014832.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183608.1 REFERENCE 1 (residues 1 to 116) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 116) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 116) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 116) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 116) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10961. Method: conceptual translation. FEATURES Location/Qualifiers source 1..116 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..116 /product="Ies4p" /calculated_mol_wt="12961" CDS 1..116 /gene="IES4" /locus_tag="YOR189W" /coded_by="NM_001183608.1:1..351" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:17693258]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:23390378]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:17693258]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Component of the INO80 chromatin remodeling complex; target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses" /db_xref="GeneID:854361" /db_xref="SGD:S000005715" ORIGIN 1 msqessvlse sqeqlannpk iedtsppsan srdnskpvlp wdyknkaiei ksfsgykvnf 61 tgwirrdvre erqrgsefta sdvkgsddka trkkepaded pevkqlekeg edglds // LOCUS NP_014833 445 aa linear PLN 30-JUN-2025 DEFINITION glucan 1,3-beta-glucosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014833 VERSION NP_014833.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183609.3 REFERENCE 1 (residues 1 to 445) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 445) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 445) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 445) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10962. On Jul 30, 2012 this sequence version replaced NP_014833.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..445 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..445 /product="glucan 1,3-beta-glucosidase" /EC_number="3.2.1.58" /calculated_mol_wt="51679" Region 114..>301 /region_name="BglC" /note="Aryl-phospho-beta-D-glucosidase BglC, GH1 family [Carbohydrate transport and metabolism]; COG2730" /db_xref="CDD:442036" CDS 1..445 /gene="SPR1" /locus_tag="YOR190W" /gene_synonym="SSG1" /coded_by="NM_001183609.3:1..1338" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0004338 glucan exo-1,3-beta-glucosidase activity [PMID:7875558]" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:19779569]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0009277 fungal-type cell wall [PMID:8419289]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:8419289]" /note="Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance; SPR1 has a paralog, EXG1, that arose from the whole genome duplication" /db_xref="GeneID:854362" /db_xref="SGD:S000005716" ORIGIN 1 mvsfrglttl tllftklvnc npvstknrds iqfiykekds iysainnqai nekihgvnlg 61 gwlvlepyit pslfetfrtn pynddgipvd eyhfceklgy ekakerlysh wstfykeedf 121 akiasqgfnl vripigywaf ttlshdpyvt aeqeyfldra idwarkyglk vwidlhgaag 181 sqngfdnsgl rdsykflede nlsatmkalt yilskystdv yldtvigiel lneplgpvid 241 merlknlllk paydylrnki nsnqiivihd afqpyhywdg flndekneyg viidhhhyqv 301 fsqveltrkm nerikiacqw gkdavsekhw svagefsaal tdctkwlngv glgarydgsw 361 tkdnekshyi ntcannenia lwpeerkqnt rkfieaqlda femtggwimw cyktensiew 421 dvekliqlni fpqpindrky pnqch // LOCUS NP_014834 1619 aa linear PLN 30-JUN-2025 DEFINITION translocase ULS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014834 VERSION NP_014834.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183610.1 REFERENCE 1 (residues 1 to 1619) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1619) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1619) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1619) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1619) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10963. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1619 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1619 /product="translocase ULS1" /calculated_mol_wt="184275" Region <936..1595 /region_name="HepA" /note="Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair]; COG0553" /db_xref="CDD:440319" Region 1324..1403 /region_name="RING-HC_ULS1-like" /note="RING finger, HC subclass, found in Saccharomyces cerevisiae ubiquitin ligase for SUMO conjugates protein 1 (ULS1) and similar proteins; cd23136" /db_xref="CDD:438498" CDS 1..1619 /gene="ULS1" /locus_tag="YOR191W" /gene_synonym="DIS1; RIS1; TID4" /coded_by="NM_001183610.1:1..4860" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18603780|PMID:22842922|PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:18603780]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:9271422]" /experiment="EXISTENCE:mutant phenotype:GO:0007533 mating type switching [PMID:9271422]" /experiment="EXISTENCE:physical interaction:GO:0032183 SUMO binding [PMID:17728242]" /note="Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL); required for maintenance of NHEJ inhibition at telomeres; functions at telomeres to translocate and ubiquitinylate poly-sumoylated Rap1p for proteosomal degradation; plays role in antagonizing silencing during mating-type switching; only known STUbL with a translocase activity; contains RING finger domain; relocalizes from nucleus to cytoplasm upon DNA replication stress" /db_xref="GeneID:854363" /db_xref="SGD:S000005717" ORIGIN 1 maavptidlt ladsdnedif hsfssstsvd kidirkengk lrmaglevaq snddaarqaf 61 hvfktnisnn etfdtilsks ktitdstfnn ekssnevkqq qvlkeetmgs sndekktqes 121 spsaemiklf yenddvplsd sfkqkeegkr inqdeqvken icgisssyvs kdydgveddf 181 epntcqdsnl dfqeeklnln nkpsqqqfsd petkdnslks enkdqikgvt ttsyrdlpie 241 ssafqdsetq nnskntipni vnekrtpalp snlssvessl knetakvegk ttvrlpglqn 301 nvalleqeqs elfkhfseqp vdisdfgrki krkhsgdfad nkilkrpilp sknmdhtthn 361 shdseqknss iiilsdedes gagindiesp lkvsepntad alrssvpevi slldlpnidl 421 nnsvikeasg snsiptsetd aqsssssvlq gtimteqatq ssqhecnssl dtlkknhqkl 481 lkdlnsrese lrnalscckt nseilrrkls rrekevsdae khwqllltsm arggrtisst 541 qqilvdeaen qlnklkekrq ltkskldsin lkmynyneqw ksfvhsknin lqkslaaler 601 sardskasat vnkrneclae kekldqmlke gtlsfstykq ltgeiqqkln dlklgdqrtt 661 dinsvlpivr qplakrdlfi ksidtakdll akntsrtemt krilyrhldn lvsyknffed 721 grslidinrr hvahesaqil ftngvkmpiv fetlqdygik fsnpaivnpd rraqyfksie 781 vardliskst rsedakrkit rflniieefr kdidtgfppt plkregvgka vvglrqqglk 841 mdrlyenlrr ykipitseel lqqsylfpvn adqrppsnwn iventedtss tandlsmqde 901 fhisnmhaae dqeqiralle nvkqsesiid gealtpedmt vnllkhqrlg lhwllqvens 961 akkgglladd mglgktiqai almlanrsee skcktnliva pvsvlrvwkg eletkvkkra 1021 kfttfifggs gngkvkhwrd larydavlvs yqtlanefkk hwpkkldgeq nqlpavphiq 1081 alnrlktsne yyspffcnds tfyrilldeg qniknkntra skacctingm yrwvlsgtpi 1141 qnsmdelysl irflrippyh keqrfkldig rffqrnkqyq ydnedrknal rkvrvllnai 1201 mlrrskadki dgkpllelpp kivevdesrl kgeelkfyta lesknqalak kllnnstrgs 1261 yssvltlllr lrqacchsel vvmgekkaeg tkvangksfe ddwlrlyyki thmsgeaqaq 1321 vitsmnsmtc fwcmeqlepe amsvltgcgh licdtciepf ieessmlpqa kktkggafai 1381 pckdcqrltn ekdivshkly dqvinqgfte edlhaeylse mekqkiqqkn vyvpnfesle 1441 pstkieqciq viqrvfdesa tekiiifsqf ttffeilehf lknklnfpyl kyigsmnaqr 1501 rsdvinefyr dpekrillis mkagnsgltl tcanhvvivd pfwnpyveeq aqdrcyrisq 1561 tkkvqvhklf ikdsvedris elqkrkkemv dsamdpgkik evnslgrrel gflfglnal // LOCUS NP_014835 599 aa linear PLN 30-JUN-2025 DEFINITION thiamine transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_014835 VERSION NP_014835.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183611.3 REFERENCE 1 (residues 1 to 599) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 599) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 599) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 599) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10964. On Jul 30, 2012 this sequence version replaced NP_014835.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..599 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..599 /product="thiamine transporter" /calculated_mol_wt="67055" Region 27..505 /region_name="SLC-NCS1sbd_NRT1-like" /note="nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain; cd11482" /db_xref="CDD:271375" Site order(53,56,342,345..346) /site_type="other" /note="Na binding site [ion binding]" /db_xref="CDD:271375" Site order(57,133,137,254..255,257,347,351) /site_type="other" /note="putative substrate binding site [chemical binding]" /db_xref="CDD:271375" CDS 1..599 /gene="THI72" /locus_tag="YOR192C" /coded_by="NM_001183611.3:1..1800" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015888 thiamine transport [PMID:16850348|PMID:9235906]" /experiment="EXISTENCE:genetic interaction:GO:1903088 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport [PMID:24778186]" /experiment="EXISTENCE:genetic interaction:GO:1903089 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity [PMID:24778186]" /note="Transporter of thiamine or related compound; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); shares sequence similarity with Thi7p" /db_xref="GeneID:854364" /db_xref="SGD:S000005718" ORIGIN 1 msfgtrisra lrfleipvkn rasvnflrnp dlqpiksvnq twgfwsnfay wgvlsfnvgm 61 wiggssaltv glsysetiga fiiadlltil falanscpgy dwkvgftlaq rfvfgiygsa 121 lgiiirilms ivyygsnawl gglcvnmild swshhylhlp ntlsskvamt tkeligfiif 181 hiltafcyfm kpyhmnyili wscvgtffam lgmviyltks ahgvgdlfts thstvtgskk 241 awawvytisy wygsvspgct nqsdfsrfgs sncaiwtgti vallipatli pvfgiigasa 301 ceklygqtfw mpmdifdnwl ttnysagara atffcgfcfv msqisytisn cgfasgmdla 361 gllpkyvdik rgaifaacvs waclpwnfyn ssstfltvms sfgvvmtpii tvmicdnfli 421 rkrqysvtna fvlkgeyyft kgvnwraiva wvcgmapglp giawevnndy fhntgiinff 481 ygdsffsfli sffvywglcl lfpfkitvkh ddkdyygaft deearkkgmv pyseiseeei 541 raytlgecft sgheykpess ddelpeltkt ssentkvfei vhqkdnekes stssekqia // LOCUS NP_878173 78 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR192C-C [Saccharomyces cerevisiae S288C]. ACCESSION NP_878173 VERSION NP_878173.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184668.1 REFERENCE 1 (residues 1 to 78) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 78) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 78) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 78) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10965. Method: conceptual translation. FEATURES Location/Qualifiers source 1..78 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..78 /product="uncharacterized protein" /calculated_mol_wt="8905" CDS 1..78 /locus_tag="YOR192C-C" /coded_by="NM_001184668.1:1..237" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466485" /db_xref="SGD:S000028857" ORIGIN 1 mmiiifielc riadslswip kslrrtsstf yipniiallk mesqqlsqns ptfqkhtpig 61 hinhdqynsd sgsyytlm // LOCUS NP_058185 1770 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058185 VERSION NP_058185.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184388.4 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10966. On Jul 30, 2012 this sequence version replaced NP_058185.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1770 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="201854" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 574..641 /region_name="gag_pre-integrs" /note="GAG-pre-integrase domain; pfam13976" /db_xref="CDD:372857" Region 660..761 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1285..>1468 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1621..1757 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1625..1628,1662..1664,1667,1700,1727,1754) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1770 /locus_tag="YOR192C-B" /coded_by="join(NM_001184388.4:1..1293, NM_001184388.4:1295..5314)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:854365" /db_xref="SGD:S000007354" ORIGIN 1 mesqqlsqns ptfhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpigsqdq hsevpqaktk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 ysdiltvlck svskmqtnnq elkdwialan leyngstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lgqqqkeskp trtidsndel pdhllidsga sqtlvrsahy lhhatpnsei 481 nivdaqkqdi pinaignlhf nfqngtktsi kalhtpniay dllslselan qnitacftrn 541 tlersdgtvl apivkhgdfy wlskkylips hiskltinnv nksksvnkyp yplihrmlgh 601 anfrsiqksl kknavtylke sdiewsnast yqcpdcligk stkhrhvkgs rlkyqesyep 661 fqylhtdifg pvhhlpksap syfisftdek trfqwvyplh drreesilnv ftsilafikn 721 qfnarvlviq mdrgseytnk tlhkfftnrg itacytttad srahgvaerl nrtllndcrt 781 llhcsglpnh lwfsavefst iirnslvspk ndksarqhag lagldittil pfgqpvivnn 841 hnpdskihpr gipgyalhps rnsygyiiyl pslkktvdtt nyvilqnkqt kldqfdydtl 901 tfdddlnrlt ahnqsfieqn eteqsydqnt esdhdyqsei einsdplvnd fssqslnplq 961 ldkepvqkvr apkevdadis eynilpstir srtphiinke stemggties dttsprhsst 1021 ftarnqkrpg spndmidlts qdrvnyglen ikttrlggte epyiqrnsdt nikyrttnst 1081 psiddrssns esttpiisie tkaacdntps idtdppeyrs sdhatpnimp dkssknvtad 1141 silddlplpd lthqsptdts dvskdiphih srqtnsslgg mddsnvlttt kskkrsledn 1201 eteievsrdt wnnknmrsle pprskkrinl iaaikgvksi kpvrttlryd eaitynkdnk 1261 ekdryveayh keisqllkmn twdtnkyydr ndidpkkvin smfifnkkrd gthkarfvar 1321 gdiqhpdtyd sdmqsntvhh yalmtslsia ldndyyitql dissaylyad ikeelyirpp 1381 phlglndkll rlrkslyglk qsganwyeti ksylinccdm qevrgwscvf knsqvticlf 1441 vddmilfskd lnankkiitt lkkqydtkii nlgegdneiq ydilgleiky qrskymklgm 1501 ekslteklpk lnvplnpkgk klrapgqpgh yidqdeleid edeykekvhe mqkliglasy 1561 vgykfrfdll yyintlaqhi lfpsrqvldm tyeliqfmwd trdkqliwhk nkptkpdnkl 1621 vaisdasygn qpyyksqign ifllngkvig gkstkasltc tstteaeiha vseaipllnn 1681 lshlvqelnk kpiikglltd srstisiiks tneekfrnrf fgtkamrlrd evsgnnlyvy 1741 yietnkniad vmtkplpikt fklltnkwih // LOCUS NP_058186 438 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058186 VERSION NP_058186.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184387.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10967. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..438 /product="gag protein" /calculated_mol_wt="49605" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..438 /locus_tag="YOR192C-A" /coded_by="NM_001184387.1:1..1317" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:854366" /db_xref="SGD:S000007353" ORIGIN 1 mesqqlsqns ptfhgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqqettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpigsqdq hsevpqaktk vrnnvlppht ltseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 ysdiltvlck svskmqtnnq elkdwialan leyngstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lrpateri // LOCUS NP_014836 376 aa linear PLN 30-JUN-2025 DEFINITION Pex27p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014836 VERSION NP_014836.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183612.3 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10968. On Jul 30, 2012 this sequence version replaced NP_014836.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..376 /product="Pex27p" /calculated_mol_wt="44000" CDS 1..376 /gene="PEX27" /locus_tag="YOR193W" /coded_by="NM_001183612.3:1..1131" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:14517321]" /experiment="EXISTENCE:genetic interaction:GO:0016559 peroxisome fission [PMID:36825558]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:14517321]" /experiment="EXISTENCE:mutant phenotype:GO:0016559 peroxisome fission [PMID:36825558]" /experiment="EXISTENCE:physical interaction:GO:0007031 peroxisome organization [PMID:14517321]" /note="Peripheral peroxisomal membrane protein; required for Vps1-dependent peroxisome fission but not Dnm1-dependent fission; functions to control peroxisome size and number; interacts with Vps1p and Pex25p; accumulates at peroxisomal membrane constrictions; PEX27 has a paralog, PEX25, that arose from the whole genome duplication" /db_xref="GeneID:854368" /db_xref="SGD:S000005719" ORIGIN 1 mtsdpvntni ssptltdrna deswellkre fntlfsnlkt dskeegnftd nkgviakkpi 61 vlqdnddsdf tqnqgkvata tsttsdrsfk rtlgsiemkk ryvkkncqak fvfntlegke 121 vcskilqhtl gllslllltr kirllnfssk lrlviqqlsl fryylrfgnf ainlykiikr 181 frwlremkkl hykdqsilfy fknfrffdii eafynltdel ilfhklqsmf gkkntshant 241 nrlmtfvkeq hyilwevlni lainknieqw rqlirdeiyl siyntsgnai keyelkyklp 301 tndkvnlelr knnitldfyk iilnllsnli nikgkrdkyn selayeiisv gsgvtellkl 361 wnrakvtsan ehtsav // LOCUS NP_014837 286 aa linear PLN 30-JUN-2025 DEFINITION transcription initiation factor IIA large subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_014837 VERSION NP_014837.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183613.1 REFERENCE 1 (residues 1 to 286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 286) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10969. Method: conceptual translation. FEATURES Location/Qualifiers source 1..286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..286 /product="transcription initiation factor IIA large subunit" /calculated_mol_wt="32070" Region 1..286 /region_name="TFIIA_alpha_beta_like" /note="Precursor of TFIIA alpha and beta subunits and similar proteins; cl21683" /db_xref="CDD:354906" Site order(8..10,12..13,16..17,20..21,25,30,34,37..38,41..42, 45..46,49,51,241..249,251,258,260,264..270,273..285) /site_type="other" /note="TFIIA subunit interface [polypeptide binding]" /db_xref="CDD:199899" Site order(250,253,255) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:199899" Site order(253,285) /site_type="other" /note="TBP interaction site [polypeptide binding]" /db_xref="CDD:199899" CDS 1..286 /gene="TOA1" /locus_tag="YOR194C" /coded_by="NM_001183613.1:1..861" /experiment="EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:10567590]" /experiment="EXISTENCE:direct assay:GO:0005672 transcription factor TFIIA complex [PMID:7862117]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:7862117]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:7604282|PMID:10567590]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:10567590]" /experiment="EXISTENCE:genetic interaction:GO:0003712 transcription coregulator activity [PMID:10567590]" /experiment="EXISTENCE:genetic interaction:GO:0017025 TBP-class protein binding [PMID:10567590]" /experiment="EXISTENCE:genetic interaction:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:10567590]" /note="TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa2p, for ribosomal protein gene transcription in vivo; homologous to largest and second largest subunits of human and Drosophila TFIIA" /db_xref="GeneID:854369" /db_xref="SGD:S000005720" ORIGIN 1 msnaeasrvy eiivesvvne vredfenagi deqtlqdlkn iwqkkltetk vttfswdnqf 61 negningvqn dlnfnlatpg vnssefnike entgneglil pninsnnnip hsgetnintn 121 tveatnnsga tlntntsgnt nadvtsqpki evkpeielti nnanittven iddesekkdd 181 eekeedvekt rkekeqieqv klqakkekrs alldtdevgs elddsdddyl isegeedgpd 241 enlmlclydk vtrtkarwkc slkdgvvtin rndytfqkaq veaewv // LOCUS NP_014838 821 aa linear PLN 30-JUN-2025 DEFINITION Slk19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014838 VERSION NP_014838.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183614.3 REFERENCE 1 (residues 1 to 821) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 821) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 821) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 821) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 821) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 821) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 821) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 821) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 821) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10970. On Jul 30, 2012 this sequence version replaced NP_014838.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..821 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..821 /product="Slk19p" /calculated_mol_wt="95250" Region 25..>185 /region_name="PTZ00482" /note="membrane-attack complex/perforin (MACPF) Superfamily; Provisional" /db_xref="CDD:240433" Region <356..699 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 742..818 /region_name="Fungal_TACC" /note="Fungal Transforming acidic coiled-coil (TACC) proteins; pfam12709" /db_xref="CDD:403801" CDS 1..821 /gene="SLK19" /locus_tag="YOR195W" /coded_by="NM_001183614.3:1..2466" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:10427094|PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:11533655]" /experiment="EXISTENCE:direct assay:GO:0051233 spindle midzone [PMID:10427094]" /experiment="EXISTENCE:direct assay:GO:0071459 protein localization to chromosome, centromeric region [PMID:30903360]" /experiment="EXISTENCE:direct assay:GO:0098653 centromere clustering [PMID:30903360]" /experiment="EXISTENCE:genetic interaction:GO:0031536 positive regulation of exit from mitosis [PMID:14551257]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:11533655|PMID:10427094]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16443750]" /experiment="EXISTENCE:mutant phenotype:GO:0007097 nuclear migration [PMID:16443750]" /experiment="EXISTENCE:mutant phenotype:GO:0031536 positive regulation of exit from mitosis [PMID:27418100|PMID:14551257]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:10835382]" /experiment="EXISTENCE:mutant phenotype:GO:0098653 centromere clustering [PMID:23283988]" /note="Kinetochore-associated protein; required for chromosome segregation and kinetochore clustering; required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate" /db_xref="GeneID:854370" /db_xref="SGD:S000005721" ORIGIN 1 mnevpttpvr lilgqaqqre qnsencsqer nprtfnsepd ssfnspgssq fvihpheple 61 kekdekqdld rsidygrssa lnnknnanpl enidinkmfd dkksdsgtnd dkggastsdk 121 hvlalnyspi rvemnssekr sdknvdvden dkegshinkk lklqlesvpd lkqsstkdii 181 ndkeeimssp maidmietni spnkfiindg verndsfnin tdtlklendi nekqqeedfi 241 ksnsnnvvni dnaykekede enditnshin rltplyetsa resnsneegr ndydddnqld 301 irhdnfqiva krneeltdqi yhlnqmlnsl iskneslsfq yeklnknhql lidltnekld 361 klnteresdi akvekfkkri kelnteikvl nsnqkilqek fdasitevnh ikgehentvn 421 tlqqnekiln dknvelenmk aelkgnndkl seyettlndl nsrivqlndk iestdivlks 481 keneldnlkl slketlsisk dfndsdligq inelistknn lqqkmddlnn lnddnlkvvq 541 dklikneetl klkeaeidsl nsemdelkkq itskddefkm wqskyetved eakirnaevt 601 elngdiedlk esklhleeti telenkvhkl enecelekqk fektsleles lqlknsniqa 661 ehikelenlh enlislqnel kissdrittl tkenevlmeq nnnnnnsvtl sndqkdrdde 721 kikslgkqvq dwkekyeake kdtnkrlkll aedlyiqyss kheqkvkllk kgyenkyqnk 781 fdqlnlenkt lseeieqlnk qlssereekq ellkllenek k // LOCUS NP_014839 414 aa linear PLN 30-JUN-2025 DEFINITION lipoate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014839 VERSION NP_014839.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183615.1 REFERENCE 1 (residues 1 to 414) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 414) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 414) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 414) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10971. Method: conceptual translation. FEATURES Location/Qualifiers source 1..414 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..414 /product="lipoate synthase" /EC_number="2.8.1.8" /calculated_mol_wt="46116" Region 104..411 /region_name="lipA" /note="lipoate synthase; TIGR00510" /db_xref="CDD:273111" CDS 1..414 /gene="LIP5" /locus_tag="YOR196C" /coded_by="NM_001183615.1:1..1245" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:11914276|P MID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0009249 protein lipoylation [PMID:19570983]" /note="Protein involved in biosynthesis of the coenzyme lipoic acid; has similarity to E. coli lipoic acid synthase" /db_xref="GeneID:854371" /db_xref="SGD:S000005722" ORIGIN 1 myrrsvgvlf vgrntrwiss tircgtsatr pirsnalntd sdnasvrvpv gnstevenat 61 sqltgtsgkr rkgnrkrite fkdalnlgps fadfvsgkas kmildpleka rqnteeakkl 121 prwlkvpipk gtnyhklkgd vkelglstvc eearcpnige cwggkdkska tatimllgdt 181 ctrgcrfcsv ktnrtpskpd pmepentaea ikrwglgyvv lttvdrddlv dgganhlaet 241 vrkikqkapn tlvetlsgdf rgdlkmvdim aqcgldvyah nletvesltp hvrdrratyr 301 qslsvlerak atvpslitkt simlglgetd eqitqtlkdl rniqcdvvtf gqymrptkrh 361 mkvveyvkpe kfdywkeral emgflycasg plvrssykag eafienvlkk rnmk // LOCUS NP_014840 432 aa linear PLN 30-JUN-2025 DEFINITION Ca(2+)-dependent cysteine protease MCA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014840 VERSION NP_014840.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183616.3 REFERENCE 1 (residues 1 to 432) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 432) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 432) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 432) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10972. On Jul 30, 2012 this sequence version replaced NP_014840.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..432 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..432 /product="Ca(2+)-dependent cysteine protease MCA1" /calculated_mol_wt="47851" Region 135..425 /region_name="Peptidase_C14" /note="Caspase domain; pfam00656" /db_xref="CDD:425803" CDS 1..432 /gene="MCA1" /locus_tag="YOR197W" /gene_synonym="YCA1" /coded_by="NM_001183616.3:1..1299" /experiment="EXISTENCE:direct assay:GO:0004198 calcium-dependent cysteine-type endopeptidase activity [PMID:29363267|PMID:22761449]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12062425]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:24855027]" /experiment="EXISTENCE:direct assay:GO:0006915 apoptotic process [PMID:11983181]" /experiment="EXISTENCE:mutant phenotype:GO:0004198 calcium-dependent cysteine-type endopeptidase activity [PMID:22761449]" /experiment="EXISTENCE:mutant phenotype:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:20624963]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:16301538|PMID:16170310]" /note="Ca2+-dependent cysteine protease; may cleave specific substrates during the stress response; regulates apoptosis upon H2O2 treatment; required for clearance of insoluble protein aggregates during normal growth; implicated in cell cycle dynamics and lifespan extension; undergoes autocatalytic processing; similar to mammalian metacaspases, but exists as a monomer due to an extra pair of anti-parallel beta-strands that block potential dimerization" /db_xref="GeneID:854372" /db_xref="SGD:S000005723" ORIGIN 1 mypgsgryty nnaggnngyq rpmapppnqq ygqqygqqye qqygqqygqq ndqqfsqqya 61 pppgpppmay nrpvypppqf qqeqakaqls ngynnpnvna snmygppqnm slpppqtqti 121 qgtdqpyqys qctgrrkali iginyigskn qlrgcindah nifnfltngy gyssddivil 181 tddqndlvrv ptranmiram qwlvkdaqpn dslflhysgh ggqtedldgd eedgmddviy 241 pvdfetqgpi iddemhdimv kplqqgvrlt alfdschsgt vldlpytyst kgiikepniw 301 kdvgqdglqa aisyatgnra aligslgsif ktvkggmgnn vdrervrqik fsaadvvmls 361 gskdnqtsad avedgqntga mshafikvmt lqpqqsylsl lqnmrkelag kysqkpqlss 421 shpidvnlqf im // LOCUS NP_014841 470 aa linear PLN 30-JUN-2025 DEFINITION Bfr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014841 VERSION NP_014841.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183617.1 REFERENCE 1 (residues 1 to 470) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 470) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 470) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 470) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10973. Method: conceptual translation. FEATURES Location/Qualifiers source 1..470 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..470 /product="Bfr1p" /calculated_mol_wt="54508" Region 18..281 /region_name="COG1340" /note="Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]" /db_xref="CDD:440951" CDS 1..470 /gene="BFR1" /locus_tag="YOR198C" /coded_by="NM_001183617.1:1..1413" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:11410665]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:11410665]" /experiment="EXISTENCE:direct assay:GO:1990904 ribonucleoprotein complex [PMID:11410665]" /experiment="EXISTENCE:mutant phenotype:GO:0003729 mRNA binding [PMID:31455610]" /experiment="EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:31455610]" /experiment="EXISTENCE:mutant phenotype:GO:0007088 regulation of mitotic nuclear division [PMID:8913743]" /experiment="EXISTENCE:mutant phenotype:GO:0008298 intracellular mRNA localization [PMID:24424022]" /experiment="EXISTENCE:mutant phenotype:GO:0035269 protein O-linked mannosylation [PMID:31835530]" /experiment="EXISTENCE:mutant phenotype:GO:0042149 cellular response to glucose starvation [PMID:24424022]" /experiment="EXISTENCE:mutant phenotype:GO:0045048 protein insertion into ER membrane [PMID:31455610]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:8913743]" /note="Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity" /db_xref="GeneID:854373" /db_xref="SGD:S000005724" ORIGIN 1 mssqqhkfkr pdvsvrdkkl dtlnvqlkki dteiglirkq idqhqvndtt qqerkklqdk 61 nkeiikiqad lktrrsnihd sikqldaqik rknnqieekl gkkakfssta eakqrineie 121 esiasgdlsl vqekllvkem qslnklikdl vniepirksv dadkakinql keelnglnpk 181 dvsnqfeenq qklndihskt qgvydkrqtl fnkraalykk rdelysqirq iradfdnefk 241 sfrakldker lkreeeqrls klleqkdvdm gklqekltha kipaftyeig aiensllvld 301 ptyvkpkkni lpdlssnale tkparkvvad dlvlvtpkkd dfvnvapsks kkykkknqqk 361 nteneqpasi fnkvdgkftl eptliatlae ldvtvpinsd dvkitveqlk kkheellskq 421 eeqtkqnies vekeieklnl dysnkeqqvk keleekrlke qeesekdken // LOCUS NP_014844 412 aa linear PLN 30-JUN-2025 DEFINITION Mrm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014844 VERSION NP_014844.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183620.3 REFERENCE 1 (residues 1 to 412) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 412) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 412) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 412) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 412) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10974. On Jul 30, 2012 this sequence version replaced NP_014844.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..412 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..412 /product="Mrm1p" /calculated_mol_wt="46256" Region 123..412 /region_name="rRNA_methyl_3" /note="rRNA methylase, putative, group 3; TIGR00186" /db_xref="CDD:129290" CDS 1..412 /gene="MRM1" /locus_tag="YOR201C" /gene_synonym="PET56" /coded_by="NM_001183620.3:1..1239" /experiment="EXISTENCE:direct assay:GO:0000154 rRNA modification [PMID:8643404]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:8643404]" /experiment="EXISTENCE:direct assay:GO:0008989 rRNA (guanine-N1-)-methyltransferase activity [PMID:8643404]" /note="Ribose methyltransferase; modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA" /db_xref="GeneID:854376" /db_xref="SGD:S000005727" ORIGIN 1 mtsltnavfk rylavtpsah qalktrikkk sssfdkffpq qsnsrkkqwe tlnedkaswf 61 krkyahvhar eqdraadpyg kkkahveklk eiknqaklnq kshkskfqnk dialklmndn 121 pifeyvygtn svyaallnps rnchsrllyh gtipskflqi vdelkvttel vdkhrlnllt 181 nygvhnnial etkplqpvei aylgdmdtss aalsihelgf nneniphelp ygtktdakkf 241 plglyldeit dphnigaiir sayflgvdfi vmsrrncspl tpvvsktssg alellpifyv 301 dkplefftks qemggwtfit shlanatsek ytvgktismh dlnglcnelp vvlvvgnesq 361 gvrtnlkmrs dffveipfgg iekgnrapep ivdslnvsva tallidnilt ck // LOCUS NP_014845 220 aa linear PLN 30-JUN-2025 DEFINITION imidazoleglycerol-phosphate dehydratase HIS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014845 VERSION NP_014845.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183621.1 REFERENCE 1 (residues 1 to 220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 220) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10975. Method: conceptual translation. FEATURES Location/Qualifiers source 1..220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..220 /product="imidazoleglycerol-phosphate dehydratase HIS3" /EC_number="4.2.1.19" /calculated_mol_wt="23702" Region 6..219 /region_name="IGPD" /note="Imidazoleglycerol-phosphate dehydratase; cd07914" /db_xref="CDD:153419" Site order(14,64,68,71..72,90..91,94,116,124..125,138,162, 186..187,190) /site_type="active" /note="putative active site pocket [active]" /db_xref="CDD:153419" Site order(60..61,64,86..88,90..91,149..153,156,158,161..162, 183..187) /site_type="other" /note="4-fold oligomerization interface [polypeptide binding]" /db_xref="CDD:153419" Site order(64,90..91,94,162,186..187,190) /site_type="metal-binding" /note="metal binding residues [ion binding]" /db_xref="CDD:153419" Site order(115,117,119..121,123..125,127..128,132..134,138,140, 174,176,178,180,198,201,207) /site_type="other" /note="3-fold/trimer interface [polypeptide binding]" /db_xref="CDD:153419" CDS 1..220 /gene="HIS3" /locus_tag="YOR202W" /gene_synonym="HIS10; HIS8" /coded_by="NM_001183621.1:1..663" /experiment="EXISTENCE:direct assay:GO:0000105 L-histidine biosynthetic process [PMID:341150]" /experiment="EXISTENCE:direct assay:GO:0004424 imidazoleglycerol-phosphate dehydratase activity [PMID:341150]" /experiment="EXISTENCE:mutant phenotype:GO:0000105 L-histidine biosynthetic process [PMID:14190241]" /experiment="EXISTENCE:mutant phenotype:GO:0004424 imidazoleglycerol-phosphate dehydratase activity [PMID:14190241]" /note="Imidazoleglycerol-phosphate dehydratase; catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p" /db_xref="GeneID:854377" /db_xref="SGD:S000005728" ORIGIN 1 mteqkalvkr itnetkiqia islkggplai ehsifpekea eavaeqatqs qvinvhtgig 61 fldhmihala khsgwslive cigdlhiddh httedcgial gqafkealga vrgvkrfgsg 121 fapldealsr avvdlsnrpy avvelglqre kvgdlscemi phflesfaea sritlhvdcl 181 rgkndhhrse safkalavai reatspngtn dvpstkgvlm // LOCUS NP_014847 604 aa linear PLN 30-JUN-2025 DEFINITION DEAD-box ATP-dependent RNA helicase DED1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014847 VERSION NP_014847.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183623.3 REFERENCE 1 (residues 1 to 604) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 604) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 604) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 604) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 604) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10976. On Jul 30, 2012 this sequence version replaced NP_014847.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..604 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..604 /product="DEAD-box ATP-dependent RNA helicase DED1" /EC_number="3.6.4.13" /calculated_mol_wt="65422" Region 141..526 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..604 /gene="DED1" /locus_tag="YOR204W" /gene_synonym="SPP81" /coded_by="NM_001183623.3:1..1815" /experiment="EXISTENCE:direct assay:GO:0000390 spliceosomal complex disassembly [PMID:16556937]" /experiment="EXISTENCE:direct assay:GO:0002151 G-quadruplex RNA binding [PMID:30855040]" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:16216083|PMID:10364207]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640|PMID:30281017]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25013175]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25013175]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:21925384]" /experiment="EXISTENCE:direct assay:GO:0033592 RNA strand annealing activity [PMID:16216083]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:30855040]" /experiment="EXISTENCE:direct assay:GO:1901195 positive regulation of formation of translation preinitiation complex [PMID:30281017]" /experiment="EXISTENCE:mutant phenotype:GO:0003724 RNA helicase activity [PMID:10364207]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:14763975|PMID:9045610]" /experiment="EXISTENCE:mutant phenotype:GO:1901195 positive regulation of formation of translation preinitiation complex [PMID:30281017]" /experiment="EXISTENCE:physical interaction:GO:0031370 eukaryotic initiation factor 4G binding [PMID:21925384]" /note="ATP-dependent DEAD-box RNA helicase with strand-annealing activity; promotes eIF4F-dependent 48S translation preinitiation complex (PIC) assembly, stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with Dbp1p in PIC attachment and scanning; ATPase activity stimulated by mRNA cap-associated factor binding; directly binds eIF4G; role in spliceosomal complex disassembly; mutation in human homolog DBY associated with male infertility; human homolog DDX3X complements the null" /db_xref="GeneID:854379" /db_xref="SGD:S000005730" ORIGIN 1 maelseqvqn lsindnneng yvpphlrgkp rsarnnssny nnnnggyngg rgggsffsnn 61 rrggygnggf fggnnggsrs ngrsggrwid gkhvpaprne kaeiaifgvp edpnfqssgi 121 nfdnyddipv dasgkdvpep iteftsppld glllenikla rftkptpvqk ysvpivangr 181 dlmacaqtgs gktggflfpv lsesfktgps pqpesqgsfy qrkayptavi maptrelatq 241 ifdeakkfty rswvkacvvy ggspignqlr eiergcdllv atpgrlndll ergkislanv 301 kylvldeadr mldmgfepqi rhivedcdmt pvgerqtlmf satfpadiqh lardflsdyi 361 flsvgrvgst senitqkvly venqdkksal ldllsastdg ltlifvetkr madqltdfli 421 mqnfrataih gdrtqserer alaafrsgaa tllvatavaa rgldipnvth vinydlpsdv 481 ddyvhrigrt gragntglat affnsensni vkglheilte anqevpsflk dammsapgsr 541 snsrrggfgr nnnrdyrkag gasaggwgss rsrdnsfrgg sgwgsdskss gwgnsggsnn 601 ssww // LOCUS NP_014848 556 aa linear PLN 30-JUN-2025 DEFINITION Gep3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014848 VERSION NP_014848.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183624.1 REFERENCE 1 (residues 1 to 556) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 556) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 556) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 556) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 556) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10977. Method: conceptual translation. FEATURES Location/Qualifiers source 1..556 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..556 /product="Gep3p" /calculated_mol_wt="63723" Region 24..470 /region_name="GTPase_YqeH" /note="ribosome biogenesis GTPase YqeH; TIGR03597" /db_xref="CDD:213834" Region 94..302 /region_name="YqeH" /note="Circularly permuted YqeH GTPase; cd01855" /db_xref="CDD:206748" Site order(159..160,162..163,198..200,222..228,301) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206748" Site 159..162 /site_type="other" /note="G4 box" /db_xref="CDD:206748" Site 198..200 /site_type="other" /note="G5 box" /db_xref="CDD:206748" Site 220..227 /site_type="other" /note="G1 box" /db_xref="CDD:206748" Site 280..287 /site_type="other" /note="Switch I region" /db_xref="CDD:206748" Site 282 /site_type="other" /note="G2 box" /db_xref="CDD:206748" Site 298..301 /site_type="other" /note="G3 box" /db_xref="CDD:206748" Site 300..302 /site_type="other" /note="Switch II region" /db_xref="CDD:206748" CDS 1..556 /gene="GEP3" /locus_tag="YOR205C" /gene_synonym="AIM40; FMP38; MTG3" /coded_by="NM_001183624.1:1..1671" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:22621929]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:22621929]" /note="Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (Phb1p)" /db_xref="GeneID:854380" /db_xref="SGD:S000005731" ORIGIN 1 mlnlchalrg vrqfscsviv kvkcascsik lqdqdpskpg yytkpkslpd sklnpdlqdl 61 kyllfsqdiq lskqatqndp dlktkrdlll rvickrcsna lhhnnynpee fpestlndil 121 nyvprgsnvm hivpfvefpl hldpnvlkrn dldttlvltk sdqvfkdkna vskkvpifmk 181 qflkntlrid snktfaisal knwnismfyn yfknytyllg npnvgkstli ntllqkylgy 241 kvkidstgki nspseevmqe aftnpknffk iqaagvship nltrsvqayq vggkilfdlp 301 gyststsrlr leeliderwl qrlrktdlfn rkhikqktye smkgtsqggc ytvggifylv 361 ppkgsinqiv kyipgpsktf kniekgidvf nscnsssgth plsrycgiks viceksqykr 421 yaippfigsi eivlkdigyi llrttgryef kglheiwipr giqvgirepl enliesgyqr 481 yietngkess cprdrpiiss lyemapdead tlnavkksyl ektekdlsar rfvdddpydl 541 vqhlekkknp ywyyqw // LOCUS NP_014849 710 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding ribosome synthesis protein NOC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014849 VERSION NP_014849.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183625.3 REFERENCE 1 (residues 1 to 710) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 710) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 710) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 710) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 710) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 710) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 710) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 710) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 710) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10978. On Jul 30, 2012 this sequence version replaced NP_014849.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..710 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..710 /product="mRNA-binding ribosome synthesis protein NOC2" /calculated_mol_wt="81471" Region 1..664 /region_name="COG5604" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227891" CDS 1..710 /gene="NOC2" /locus_tag="YOR206W" /coded_by="NM_001183625.3:1..2133" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11371346|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:11371346]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23209026]" /experiment="EXISTENCE:direct assay:GO:0030690 Noc1p-Noc2p complex [PMID:11371346]" /experiment="EXISTENCE:direct assay:GO:0030691 Noc2p-Noc3p complex [PMID:11371346]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:23209026|PMID:11371346]" /note="Protein involved in ribosome biogenesis; forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes; forms a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors; acts as part of a Mak21p-Noc2p-Rrp5p module that associates with nascent pre-rRNA during transcription and has a role in bigenesis of the large ribosomal subunit" /db_xref="GeneID:854381" /db_xref="SGD:S000005732" ORIGIN 1 mgkvskstkk fqskhlkhtl dqrrkekiqk kriqgrrgnk tdqekadaag treqqqlkks 61 akeevfkdms vetffekgie ipkenkklkk kttkeqsded sssseeeedm gqsmaklaek 121 dpefykylee ndkdlldfag tnpldgidsq degedaerns nieekseqme lekekielsl 181 klvrkwkkql hdspslkllr niisafkvav nlnkeenied ykyaitdeka fhelmfmvlk 241 dvpqaiqkma pykivkgart lpnggnvsrv ssivkshags llillnditn tetaalvlhs 301 vnelmpylls yrrilkelik sivgvwsttr eletqiasfa flinttkefk ksmlettlkt 361 tystfikscr ktnmrsmpli nfqknsaael fgidevlgyq vgfeyirqla ihlrntmnat 421 tkksskinsa eaykivynwq fchsldfwsr vlsfacqpek engsesplrq liyplvqvtl 481 gvirliptpq ffplrfylik slirlsqnsg vfipiyplls eiltstaftk apkkspnlaa 541 fdfehnikct qaylntkiyq eglseqfvdl lgdyfalyck niafpelvtp viislrryik 601 tstnvklnkr lstvveklnq nstfiqekrs dvefgptnks evsrflndva wnktplgsyv 661 avqrevkeek arlmresmee qdkereteea kllnslesdd dnedvemsda // LOCUS NP_014850 1149 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase III core subunit RET1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014850 VERSION NP_014850.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183626.1 REFERENCE 1 (residues 1 to 1149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1149) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10979. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1149 /product="DNA-directed RNA polymerase III core subunit RET1" /EC_number="2.7.7.6" /calculated_mol_wt="129326" Region 57..1141 /region_name="RNA_pol_B_RPB2" /note="RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; cd00653" /db_xref="CDD:238353" Site order(121,784,825,827,831..833,835) /site_type="other" /note="RPB12 interaction site [polypeptide binding]" /db_xref="CDD:238353" Site order(485,487..489,491,494,499,674,692..694,696,759..762, 765,767..769,919,921,923,945,947,950,953,958,962,979,1006, 1014..1016,1018,1031,1034..1036,1038..1039,1060..1062,1066, 1068..1069,1071,1073..1078,1080..1085,1089,1122,1126,1128, 1130..1131,1133,1135..1138,1140) /site_type="other" /note="RPB1 interaction site [polypeptide binding]" /db_xref="CDD:238353" Region 555..615 /region_name="RNA_pol_Rpb2_4" /note="RNA polymerase Rpb2, domain 4; pfam04566" /db_xref="CDD:428012" Region 637..677 /region_name="RNA_pol_Rpb2_5" /note="RNA polymerase Rpb2, domain 5; pfam04567" /db_xref="CDD:428013" Site order(732..733,754,756,777,780,928,941,968..969,971,1002, 1019) /site_type="other" /note="RPB10 interaction site [polypeptide binding]" /db_xref="CDD:238353" Site order(765,779,927,1008) /site_type="other" /note="RPB11 interaction site [polypeptide binding]" /db_xref="CDD:238353" Site order(779..780,784,901,903,928..930,933,935..936, 1007..1014,1016) /site_type="other" /note="RPB3 interaction site [polypeptide binding]" /db_xref="CDD:238353" CDS 1..1149 /gene="RET1" /locus_tag="YOR207C" /gene_synonym="PDS2; RPC128; RPC2" /coded_by="NM_001183626.1:1..3450" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:genetic interaction:GO:0042797 tRNA transcription by RNA polymerase III [PMID:2199311]" /note="Second-largest subunit of RNA polymerase III; RNA polymerase III is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs" /db_xref="GeneID:854382" /db_xref="SGD:S000005733" ORIGIN 1 mvaatkrrkt hihkhvkdea fddllkpvyk gkkltdeint aqdkwhllpa flkvkglvkq 61 hldsfnyfvd tdlkkiikan qlilsdvdpe fylkyvdirv gkksssstkd yltpphecrl 121 rdmtysapiy vdieytrgrn iimhkdveig rmpimlrsnk cilydadesk maklnecpld 181 pggyfivngt ekvilvqeql sknriivead ekkgivqasv tsstherksk tyvitkngki 241 ylkhnsiaee ipiaivlkac gilsdleimq lvcgndssyq difavnlees skldiytqqq 301 aleyigakvk tmrrqkltil qegieaiatt viahltveal dfrekalyia mmtrrvvmam 361 ynpkmiddrd yvgnkrlela gqlisllfed lfkkfnndfk lsidkvlkkp nrameydall 421 sinvhsnnit sglnraistg nwslkrfkme ragvthvlsr lsyisalgmm trissqfeks 481 rkvsgpralq psqfgmlcta dtpegeacgl vknlalmthi ttddeeepik klcyvlgved 541 itlidsaslh lnygvylngt ligsirfptk fvtqfrhlrr tgkvsefisi ysnshqmavh 601 iatdggricr pliivsdgqs rvkdihlrkl ldgeldfddf lklglveyld vneendsyia 661 lyekdivpsm thleiepfti lgavaglipy phhnqsprnt yqcamgkqai gaiaynqfkr 721 idtllylmty pqqpmvktkt ielidydklp agqnatvavm sysgydieda lvlnkssidr 781 gfgrcetrrk tttvlkryan htqdiiggmr vdengdpiwq hqslgpdglg evgmkvqsgq 841 iyinksvptn sadapnpnnv nvqtqyreap viyrgpepsh idqvmmsvsd ndqalikvll 901 rqnrrpelgd kfssrhgqkg vcgiivkqed mpfndqgivp diimnphgfp srmtvgkmie 961 lisgkagvln gtleygtcfg gskledmski lvdqgfnysg kdmlysgitg eclqayiffg 1021 piyyqklkhm vldkmharar gpravltrqp tegrsrdggl rlgemerdcv iaygasqlll 1081 erlmissdaf evdvcdkcgl mgysgwcttc ksaeniikmt ipyaakllfq ellsmniapr 1141 lrledifqq // LOCUS NP_014851 750 aa linear PLN 30-JUN-2025 DEFINITION tyrosine protein phosphatase PTP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014851 VERSION NP_014851.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183627.3 REFERENCE 1 (residues 1 to 750) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 750) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 750) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 750) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 750) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10980. On Jul 30, 2012 this sequence version replaced NP_014851.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..750 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..750 /product="tyrosine protein phosphatase PTP2" /EC_number="3.1.3.48" /calculated_mol_wt="85738" Region 467..732 /region_name="PTP_fungal" /note="fungal protein tyrosine phosphatases; cd18533" /db_xref="CDD:350509" CDS 1..750 /gene="PTP2" /locus_tag="YOR208W" /coded_by="NM_001183627.3:1..2253" /experiment="EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:10523653]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10523653]" /experiment="EXISTENCE:direct assay:GO:1903138 negative regulation of cell integrity MAPK cascade [PMID:9224718]" /experiment="EXISTENCE:genetic interaction:GO:0043937 regulation of sporulation [PMID:10679022]" /experiment="EXISTENCE:genetic interaction:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:10523653]" /experiment="EXISTENCE:mutant phenotype:GO:0051457 maintenance of protein location in nucleus [PMID:10817757]" /experiment="EXISTENCE:mutant phenotype:GO:0071474 cellular hyperosmotic response [PMID:10817757]" /experiment="EXISTENCE:mutant phenotype:GO:0071507 pheromone response MAPK cascade [PMID:9224718]" /experiment="EXISTENCE:mutant phenotype:GO:0071852 fungal-type cell wall organization or biogenesis [PMID:10523653]" /note="Phosphotyrosine-specific phosphatase; major role in osmolarity sensing through dephosphorylation of the Hog1p MAPK with a minor role by Ptp3p; inactivates and regulates Hog1p localization; major role in the cell wall integrity pathway through dephosphorylation of MAPK Slt2p with a minor role by Ptp3p; minor role with Msg5p in the pheromone adaptive response through dephosphorylation of MAPK Fus3p with major role by Ptp3p; co-regulates the calcium signaling pathway with Msg5p; nuclear localized" /db_xref="GeneID:854383" /db_xref="SGD:S000005734" ORIGIN 1 mdriaqqyrn gkrdnngnrm assaisekgh iqvnqtrtpg qmpvyrgeti nlsnlpqnqi 61 kpckdlddvn irrnnsnrhs killldlcag pntnsflgnt nakditvlsl plpstlvkrs 121 nypfenllkn ylgsdekyie ftkiikdydi fifsdsfsri ssclkttfcl iekfkkfich 181 ffpspylkff llegslndsk apslgknkkn cilpkldlnl nvnltsrstl nlrinipppn 241 dsnkiflqsl kkdlihyspn slqkffqfnm padlapndti lpnwlkfcsv kenekvilkk 301 lfnnfetlen femqrlekcl kfkkkplhqk qlsqkqrgpq stddsklysl tslqrqykss 361 lksniqknqk lkliipknnt ssspsplssd dtimspindy eltegiqsft knrysnilpy 421 ehsrvklphs pkppavseas ttetktdksy pmcpvdaknh sckpndyina nylkltqinp 481 dfkyiatqap lpstmddfwk vitlnkvkvi islnsddeln lrkwdiywnn lsysnhtikl 541 qntwenicni ngcvlrvfqv kktapqndni sqdcdlphng dltsitmavs epfivyqlqy 601 knwldscgvd mndiiklhkv knsllfnpqs fitslekdvc kpdliddnns elhldtanss 661 pllvhcsagc grtgvfvtld fllsilsptt nhsnkidvwn mtqdlifiiv nelrkqrism 721 vqnltqyiac yeallnyfal qkqiknalpc // LOCUS NP_014852 429 aa linear PLN 30-JUN-2025 DEFINITION nicotinate phosphoribosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014852 VERSION NP_014852.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183628.1 REFERENCE 1 (residues 1 to 429) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 429) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 429) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 429) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10981. Method: conceptual translation. FEATURES Location/Qualifiers source 1..429 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..429 /product="nicotinate phosphoribosyltransferase" /EC_number="6.3.4.21" /calculated_mol_wt="48888" Region 5..416 /region_name="NAPRTase" /note="nicotinate phosphoribosyltransferase; TIGR01514" /db_xref="CDD:130578" CDS 1..429 /gene="NPT1" /locus_tag="YOR209C" /coded_by="NM_001183628.1:1..1290" /experiment="EXISTENCE:direct assay:GO:0004516 nicotinate phosphoribosyltransferase activity [PMID:9521740]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11884393]" /experiment="EXISTENCE:direct assay:GO:0019358 nicotinate nucleotide salvage [PMID:11884393]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:11901108]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11901108]" /note="Nicotinate phosphoribosyltransferase; acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus" /db_xref="GeneID:854384" /db_xref="SGD:S000005735" ORIGIN 1 msepviksll dtdmykitmh aavftnfpdv tvtykytnrs sqltfnkeai nwlkeqfsyl 61 gnlrfteeei eylkqeipyl psayikyiss snyklhpeeq isftseeieg kpthyklkil 121 vsgswkdtil yeipllslis eayfkfvdid wdyenqleqa ekkaetlfdn girfsefgtr 181 rrrslkaqdl imqgimkavn gnpdrnksll lgtsnilfak kygvkpigtv ahewvmgvas 241 isedylhank namdcwintf gaknaglalt dtfgtddflk sfrppysday vgvrqdsgdp 301 veytkkishh yhdvlklpkf skiicysdsl nvekaitysh aakengmlat fgigtnftnd 361 frkksepqvk seplnivikl levngnhaik isdnlgknmg dpatvkrvke elgytersws 421 gdneahrwt // LOCUS NP_014853 70 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase core subunit RPB10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014853 VERSION NP_014853.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183629.3 REFERENCE 1 (residues 1 to 70) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 70) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 70) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 70) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 70) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10982. On Jul 30, 2012 this sequence version replaced NP_014853.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..70 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..70 /product="DNA-directed RNA polymerase core subunit RPB10" /calculated_mol_wt="8147" Region 1..70 /region_name="RNA_pol_N" /note="RNA polymerases N / 8 kDa subunit; cl00712" /db_xref="CDD:469886" CDS 1..70 /gene="RPB10" /locus_tag="YOR210W" /coded_by="NM_001183629.3:1..213" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793|PMID:8288647|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1748681|PMID:1331084]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793|PMID:1748681]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:1748681|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:1748681]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:genetic interaction:GO:0006360 transcription by RNA polymerase I [PMID:10085073]" /experiment="EXISTENCE:mutant phenotype:GO:0006360 transcription by RNA polymerase I [PMID:10085073]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:17179178]" /note="RNA polymerase subunit ABC10-beta; common to RNA polymerases I, II, and III" /db_xref="GeneID:854385" /db_xref="SGD:S000005736" ORIGIN 1 mivpvrcfsc gkvvgdkwes ylnllqedel degtalsrlg lkryccrrmi lthvdliekf 61 lrynplekrd // LOCUS NP_014854 881 aa linear PLN 30-JUN-2025 DEFINITION dynamin-related GTPase MGM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014854 VERSION NP_014854.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183630.1 REFERENCE 1 (residues 1 to 881) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 881) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 881) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 881) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10983. On Oct 10, 2006 this sequence version replaced NP_014854.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..881 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..881 /product="dynamin-related GTPase MGM1" /EC_number="3.6.5.5" /calculated_mol_wt="99047" Region 208..468 /region_name="DLP_1" /note="Dynamin_like protein family includes dynamins and Mx proteins; cd08771" /db_xref="CDD:206738" Site 217..224 /site_type="other" /note="G1 box" /db_xref="CDD:206738" Site order(218,220..225,238..239,244,317,386,388..389,414..418, 421) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206738" Site order(219..220,321,334,358,360,362..365,367..368,389, 391..394,417..419) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:206738" Site 244 /site_type="other" /note="G2 box" /db_xref="CDD:206738" Site 248..250 /site_type="other" /note="Switch I region" /db_xref="CDD:206738" Site 317..320 /site_type="other" /note="G3 box" /db_xref="CDD:206738" Site 385..388 /site_type="other" /note="G4 box" /db_xref="CDD:206738" Site 414..416 /site_type="other" /note="G5 box" /db_xref="CDD:206738" CDS 1..881 /gene="MGM1" /locus_tag="YOR211C" /gene_synonym="MNA1" /coded_by="NM_001183630.1:1..2646" /experiment="EXISTENCE:direct assay:GO:0001786 phosphatidylserine binding [PMID:19236101]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:19236101]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:27849155]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:19505460]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:11038181]" /experiment="EXISTENCE:direct assay:GO:0030061 mitochondrial crista [PMID:19505460]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:19236101]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:19236101]" /experiment="EXISTENCE:direct assay:GO:0097002 mitochondrial inner boundary membrane [PMID:27849155|PMID:19505460]" /experiment="EXISTENCE:direct assay:GO:1901612 cardiolipin binding [PMID:19236101]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:1532158]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:15125685]" /experiment="EXISTENCE:mutant phenotype:GO:0008053 mitochondrial fusion [PMID:17055438|PMID:12808034]" /experiment="EXISTENCE:mutant phenotype:GO:0015886 heme transport [PMID:32265272]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:27849155]" /note="Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mitochondrial morphology, fusion, and genome maintenance; promotes membrane bending; plays a direct role in formation and maintenance of lamellar, but not of tubular, cristae; exists as long and short form with different distributions; ratio of long to short forms is regulated by Psd1p; homolog of human OPA1 involved in autosomal dominant optic atrophy" /db_xref="GeneID:854386" /db_xref="SGD:S000005737" ORIGIN 1 mnaspvrlli lrrqlathpa ilysspyiks plvhlhsrms nvhrsahana lsfvitrrsi 61 shfpkiiski irlpiyvggg maaagsyiay kmeeassftk dkldrikdlg esmkekfnkm 121 fsgdksqdgg hgndgtvpta tliaatsldd deskrqgdpk ddddedddde ddendsvdtt 181 qdemlnltkq mieirtilnk vdsssahltl psivvigsqs sgkssvlesi vgreflpkgs 241 nmvtrrpiel tlvntpnsnn vtadfpsmrl ynikdfkevk rmlmelnmav ptseavseep 301 iqltikssrv pdlslvdlpg yiqveaadqp ielktkirdl cekyltapni ilaisaadvd 361 lanssalkas kaadpkglrt igvitkldlv dpekarsiln nkkyplsmgy vgvitktpss 421 inrkhlglfg eapssslsgi fskgqhgqss geentnglkq ivshqfekay fkenkkyftn 481 cqvstkklre klikileism snaleptstl iqqelddtsy lfkvefndrh ltpksyllnn 541 idvlklgike fqekfhrnel ksilraeldq kvldvlatry wkddnlqdls ssklesdtdm 601 lywhkklela ssgltkmgig rlstmlttna ilkeldnile stqlknheli kdlvsntain 661 vlnskyysta dqvencikpf kyeidleerd wslarqhsin likeelrqcn sryqaiknav 721 gskklanvmg ylenesnlqk etlgmsklll ergseaifld krckvlsfrl kmlknkchst 781 iekdrcpevf lsavsdklts tavlflnvel lsdffynfpi eldrrltllg deqvemfake 841 dpkisrhiel qkrkellela lekidsilvf kksykgvskn l // LOCUS NP_014855 423 aa linear PLN 30-JUN-2025 DEFINITION G protein subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_014855 VERSION NP_014855.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183631.3 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10984. On Jul 30, 2012 this sequence version replaced NP_014855.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..423 /product="G protein subunit beta" /calculated_mol_wt="46450" Region 87..419 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(91,109,113,119..120,132..133,151,155,161..162, 179..180,197,201,207..208,221,245,249,255..256,268..269, 287,291,297..298,313,348,365,370,376..377,389..390,408,412, 418..419) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 95..132 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 138..179 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 184..218 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 226..266 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 273..329 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 352..388 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 394..418 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..423 /gene="STE4" /locus_tag="YOR212W" /gene_synonym="HMD2" /coded_by="NM_001183631.3:1..1272" /experiment="EXISTENCE:direct assay:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:9428767]" /experiment="EXISTENCE:direct assay:GO:0005834 heterotrimeric G-protein complex [PMID:8995254]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8995254]" /experiment="EXISTENCE:direct assay:GO:0005937 mating projection [PMID:11073983]" /experiment="EXISTENCE:direct assay:GO:0019901 protein kinase binding [PMID:9428767]" /experiment="EXISTENCE:direct assay:GO:0031680 G-protein beta/gamma-subunit complex [PMID:8995254|PMID:8417317]" /experiment="EXISTENCE:direct assay:GO:0120171 Cdc24p-Far1p-Gbetagamma complex [PMID:10087263]" /experiment="EXISTENCE:genetic interaction:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:2107073]" /experiment="EXISTENCE:genetic interaction:GO:0031680 G-protein beta/gamma-subunit complex [PMID:8417317]" /experiment="EXISTENCE:mutant phenotype:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:9732267|PMID:12660244|PMID:10087263]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:2107073]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:15192700]" /experiment="EXISTENCE:mutant phenotype:GO:0005834 heterotrimeric G-protein complex [PMID:2105453]" /experiment="EXISTENCE:mutant phenotype:GO:0031267 small GTPase binding [PMID:12660244]" /experiment="EXISTENCE:mutant phenotype:GO:0043577 chemotropism [PMID:10087263|PMID:23613469]" /experiment="EXISTENCE:mutant phenotype:GO:0061951 establishment of protein localization to plasma membrane [PMID:9732267]" /experiment="EXISTENCE:mutant phenotype:GO:1903260 protein localization to mating projection tip [PMID:12660244]" /experiment="EXISTENCE:physical interaction:GO:0000749 response to pheromone triggering conjugation with cellular fusion [PMID:9428767]" /experiment="EXISTENCE:physical interaction:GO:0001965 G-protein alpha-subunit binding [PMID:8417317]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:8649369]" /experiment="EXISTENCE:physical interaction:GO:0019901 protein kinase binding [PMID:9428767]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:12660244]" /experiment="EXISTENCE:physical interaction:GO:0031680 G-protein beta/gamma-subunit complex [PMID:8649369]" /experiment="EXISTENCE:physical interaction:GO:0031682 G-protein gamma-subunit binding [PMID:8649369|PMID:8417317]" /experiment="EXISTENCE:physical interaction:GO:0097110 scaffold protein binding [PMID:7667635]" /experiment="EXISTENCE:physical interaction:GO:0120171 Cdc24p-Far1p-Gbetagamma complex [PMID:10087263]" /note="G protein beta subunit; forms a dimer with Ste18p to activate mating signaling pathway, forms heterotrimer with Gpa1p and Ste18p to dampen signaling; pheromone-induced phosphorylation plays critical role in chemotropism; may recruit Rho1p to polarized growth site during mating; contains WD40 repeats" /db_xref="GeneID:854387" /db_xref="SGD:S000005738" ORIGIN 1 maahqmdsit ysnnvtqqyi qpqslqdisa vedeiqnkie aarqeskqlh aqinkakhki 61 qdaslfqman kvtsltknki nlkpnivlkg hnnkisdfrw srdskrilsa sqdgfmliwd 121 sasglkqnai pldsqwvlsc aispsstlva saglnnncti yrvskenrva qnvasifkgh 181 tcyisdieft dnahiltasg dmtcalwdip kakrvreysd hlgdvlalai peepnsenss 241 ntfascgsdg ytyiwdsrsp savqsfyvnd sdinalrffk dgmsivagsd ngainmydlr 301 sdcsiatfsl frgyeertpt ptymaanmey ntaqspqtlk stsssyldnq gvvsldfsas 361 grlmyscytd igcvvwdvlk geivgklegh ggrvtgvrss pdglavctgs wdstmkiwsp 421 gyq // LOCUS NP_014856 248 aa linear PLN 30-JUN-2025 DEFINITION Sas5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014856 VERSION NP_014856.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183632.1 REFERENCE 1 (residues 1 to 248) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 248) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 248) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 248) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10985. Method: conceptual translation. FEATURES Location/Qualifiers source 1..248 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..248 /product="Sas5p" /calculated_mol_wt="28887" Region 1..245 /region_name="TFG3" /note="Transcription initiation factor IIF, auxiliary subunit [Transcription]; COG5033" /db_xref="CDD:227366" CDS 1..248 /gene="SAS5" /locus_tag="YOR213C" /coded_by="NM_001183632.1:1..747" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:11731479]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:12626510]" /experiment="EXISTENCE:direct assay:GO:0016407 acetyltransferase activity [PMID:11731479]" /experiment="EXISTENCE:direct assay:GO:0031509 subtelomeric heterochromatin formation [PMID:11731479]" /experiment="EXISTENCE:direct assay:GO:0033255 SAS acetyltransferase complex [PMID:12626510]" /experiment="EXISTENCE:physical interaction:GO:0033255 SAS acetyltransferase complex [PMID:15788653]" /note="Subunit of the SAS complex (Sas2p, Sas4p, Sas5p); acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity" /db_xref="GeneID:854388" /db_xref="SGD:S000005739" ORIGIN 1 mdhsievtfr vktqqviipe qnirgnelpl rrwqmellml datgkevept ilskciyhlh 61 ssfkqpkrrl nslpffiket gwgefnlkie cffignagkf siehdltfed dayavdytvd 121 vphefshlns elskyfdlpw kvvspeeems lriadlpwik slalidedmm tdvvqmilnd 181 pavqraienh prreqffmfi tqlpddllmk iqaflklpnk nstkqertnf gsdaihkdep 241 vkahnklk // LOCUS NP_014857 236 aa linear PLN 30-JUN-2025 DEFINITION Spr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014857 VERSION NP_014857.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183633.3 REFERENCE 1 (residues 1 to 236) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 236) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 236) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 236) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10986. On Jul 30, 2012 this sequence version replaced NP_014857.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..236 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..236 /product="Spr2p" /calculated_mol_wt="26026" CDS 1..236 /gene="SPR2" /locus_tag="YOR214C" /coded_by="NM_001183633.3:1..711" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /note="Putative spore wall protein; expression increases during sporulation; not an essential gene; YOR214C has a paralog, SPO19, that arose from the whole genome duplication" /db_xref="GeneID:854389" /db_xref="SGD:S000005740" ORIGIN 1 mlglylsslf faffmaqvfa tkysitftsd eyeedetgqn epgplvfhld knslppalln 61 qmefnpylvl adlpeeprav dsqehtdtvl asksvidfll edpltivehk kfsqiesilh 121 eimedsiqkk vgadevfeei pkpkiyayed ilvtnmsiin nsemptstat ltstisylss 181 ttslalstgv tsveifptit pgnittiggy ensssslmps mgilsflfgl ylllhp // LOCUS NP_014858 185 aa linear PLN 30-JUN-2025 DEFINITION Aim41p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014858 VERSION NP_014858.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183634.1 REFERENCE 1 (residues 1 to 185) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 185) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 185) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 185) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10987. Method: conceptual translation. FEATURES Location/Qualifiers source 1..185 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..185 /product="Aim41p" /calculated_mol_wt="21098" Region 32..>116 /region_name="YqeY" /note="Uncharacterized conserved protein YqeY, may have tRNA amino acid amidase activity [General function prediction only]; COG1610" /db_xref="CDD:441218" CDS 1..185 /gene="AIM41" /locus_tag="YOR215C" /coded_by="NM_001183634.1:1..558" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:24769239|PMID:16823961]" /note="hypothetical protein; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss" /db_xref="GeneID:854390" /db_xref="SGD:S000005741" ORIGIN 1 mfrqsirplv snrltfiryn sspaytaavs llkgdlkkam iakdemkkta irnmlsaikn 61 keialkgksa deyslydmys klisqrkdsi neflankrdd lvakeqgemd iikkymdqlp 121 vsseldidqn vkklldalkt kagekkvqik eimgeidwks lptewktspt aiknsivkqf 181 keifk // LOCUS NP_014859 484 aa linear PLN 30-JUN-2025 DEFINITION Rud3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014859 VERSION NP_014859.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183635.3 REFERENCE 1 (residues 1 to 484) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 484) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 484) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 484) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10988. On Jul 30, 2012 this sequence version replaced NP_014859.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..484 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..484 /product="Rud3p" /calculated_mol_wt="55938" Region 88..>382 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 401..449 /region_name="GRAB" /note="GRAB domain; pfam10375" /db_xref="CDD:431241" CDS 1..484 /gene="RUD3" /locus_tag="YOR216C" /gene_synonym="GRP1" /coded_by="NM_001183635.3:1..1455" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:15504911]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051020 GTPase binding [PMID:15504911]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:10562277|PMID:10512869]" /note="Golgi matrix protein; involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1" /db_xref="GeneID:854391" /db_xref="SGD:S000005742" ORIGIN 1 mgknkkktgk kakshphved vdetvnkpee iinsvnvtvp pkmstdpead givaspddeg 61 kdlsegvdkq kvndgltvdt inpledkkag demkelreei erlklelshk kdqetpnedf 121 knelanvike rdefktqydt llskissmks ifnkmkeaqk qleevqeqlt eyesqnlklk 181 kkleatkten selqstivtl ntelenleke qesteevfle yesriealed ekhdiiekhs 241 kelntyrkek dqlnlqvqel miilennkqd isdlrterde lrqaleshek ekavlknsln 301 dlelkieevd nkreeearer dqevkslrsq ldteiethnn dtealesmkk qleamkedas 361 mkekyeeesk qhilqigklr heaiilnehl tkalamlkks sdsesvdkel isnllisfvs 421 ipradprkfe vlellsnfln wdedkkqqag lisnneskns savsrtesfv slwtnyleke 481 sekd // LOCUS NP_014860 861 aa linear PLN 30-JUN-2025 DEFINITION replication factor C subunit 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014860 VERSION NP_014860.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183636.1 REFERENCE 1 (residues 1 to 861) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 861) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 861) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 861) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10989. Method: conceptual translation. FEATURES Location/Qualifiers source 1..861 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..861 /product="replication factor C subunit 1" /calculated_mol_wt="94772" Region 153..230 /region_name="BRCT" /note="C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; cl00038" /db_xref="CDD:469589" Region 298..762 /region_name="PRK04195" /note="replication factor C large subunit; Provisional" /db_xref="CDD:235250" Region 621..776 /region_name="RFC1" /note="Replication factor RFC1 C terminal domain; pfam08519" /db_xref="CDD:462507" CDS 1..861 /gene="RFC1" /locus_tag="YOR217W" /gene_synonym="CDC44" /coded_by="NM_001183636.1:1..2586" /experiment="EXISTENCE:direct assay:GO:0003689 DNA clamp loader activity [PMID:8995429]" /experiment="EXISTENCE:direct assay:GO:0005663 DNA replication factor C complex [PMID:7651383]" /experiment="EXISTENCE:direct assay:GO:0006272 leading strand elongation [PMID:1346062]" /experiment="EXISTENCE:genetic interaction:GO:0000278 mitotic cell cycle [PMID:7516465]" /experiment="EXISTENCE:genetic interaction:GO:0006298 mismatch repair [PMID:9504910]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:6749598|PMID:6749599]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:8770585]" /note="Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon" /db_xref="GeneID:854392" /db_xref="SGD:S000005743" ORIGIN 1 mvnisdffgk nkksvrssts rptrqvgssk pevidldtes dqestnktpk kmpvsnvidv 61 setpegekkl plpakrkass ptvkpasskk tkpsskssds asnitaqdvl dkipsldlsn 121 vhvkenakfd fksansnadp deivseigsf pegkpncllg ltivftgvlp tlergaseal 181 akrygarvtk sissktsvvv lgdeagpkkl ekikqlkika ideegfkqli agmpaeggdg 241 eaaekarrkl eeqhniatke aellvkkeee rskklaatrv sgghlerdnv vreedklwtv 301 kyaptnlqqv cgnkgsvmkl knwlanwens kknsfkhagk dgsgvfraam lygppgigkt 361 taahlvaqel gydileqnas dvrsktllna gvknaldnms vvgyfkhnee aqnlngkhfv 421 iimdevdgms ggdrggvgql aqfcrktstp lilicnernl pkmrpfdrvc ldiqfrrpda 481 nsiksrlmti airekfkldp nvidrliqtt rgdirqvinl lstistttkt inhenineis 541 kaweknialk pfdiahkmld gqiysdigsr nftlndkial yfddfdftpl miqenylstr 601 psvlkpgqsh leavaeaanc islgdivekk irsseqlwsl lplhavlssv ypaskvaghm 661 agrinftawl gqnsksakyy rllqeihyht rlgtstdkig lrldylptfr krlldpflkq 721 gadaissvie vmddyyltke dwdsimeffv gpdvttaiik kipatvksgf trkynsmthp 781 vaiyrtgsti ggggvgtsts tpdfedvvda ddnpvpadde etqdsstdlk kdklikqkak 841 ptkrktatsk pggskkrktk a // LOCUS NP_014862 931 aa linear PLN 30-JUN-2025 DEFINITION Ste13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014862 VERSION NP_014862.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183638.3 REFERENCE 1 (residues 1 to 931) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 931) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 931) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 931) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 931) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 931) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 931) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 931) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 931) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10990. On Jul 30, 2012 this sequence version replaced NP_014862.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..931 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..931 /product="Ste13p" /calculated_mol_wt="107070" Region 247..623 /region_name="DPPIV_N" /note="Dipeptidyl peptidase IV (DPP IV) N-terminal region; pfam00930" /db_xref="CDD:395744" Region 713..919 /region_name="Peptidase_S9" /note="Prolyl oligopeptidase family; pfam00326" /db_xref="CDD:459761" CDS 1..931 /gene="STE13" /locus_tag="YOR219C" /gene_synonym="YCI1" /coded_by="NM_001183638.3:1..2796" /experiment="EXISTENCE:direct assay:GO:0004177 aminopeptidase activity [PMID:6339075]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:8308064]" /experiment="EXISTENCE:direct assay:GO:0007323 peptide pheromone maturation [PMID:6339075]" /experiment="EXISTENCE:mutant phenotype:GO:0007323 peptide pheromone maturation [PMID:6339075]" /note="Dipeptidyl aminopeptidase; Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor" /db_xref="GeneID:854394" /db_xref="SGD:S000005745" ORIGIN 1 msasthshkr knshlfpqrk ssnssmdkpf fpnndsvant dpqsnenght ineirpteat 61 idvtdvpqtp flqeqysmrp rresfqfndi enqhhthsff svnkfnrrwg ewslpekrsy 121 vlvftlials vlvllvilip skllptkitr pktsagdssl gkrsfsienv lngdfaiped 181 tfhfidppqr llgqdsdpgl yfttkeidgh tnfiakqlfd etfevnlggn rflyegveft 241 vstvqinykl dklifgtnle sefrhsskgf ywikdlntgn iepilppeks ddnyelglsk 301 lsyahfspay nyiyfvyenn lflqqvnsgv akkvtedgsk difnakpdwi yeeevlasdq 361 aiwwapddsk avfarfndts vddirlnryt nmneaylsdt kikypkpgfq npqfdlflvn 421 lqngiiysin tggqkdsily ngkwispdtf rfeitdrnsk ildvkvydip ssqmltvrnt 481 nsnlfngwie ktkdilsipp kpelkrmdyg yidihadsrg fshlfyyptv fakepiqltk 541 gnwevtgngi vgyeyetdti fftaneigvm sqhlysislt dsttqntfqs lqnpsdkydf 601 ydfelsssar yaiskklgpd tpikvagplt rvlnvaeihd dsilqltkde kfkekiknyd 661 lpitsyktmv lddgveinyi eikpanlnpk kkypilvniy ggpgsqtftt ksslafeqav 721 vsgldvivlq ieprgtggkg wsfrswarek lgyweprdit evtkkfiqrn sqhideskia 781 iwgwsyggft slktveldng dtfkyamava pvtnwtlyds vyterymnqp senhegyfev 841 stiqnfksfe slkrlfivhg tfddnvhiqn tfrlvdqlnl lgltnydmhi fpdsdhsiry 901 hnaqrivfqk lyywlrdafa erfdntevlh l // LOCUS NP_014863 265 aa linear PLN 30-JUN-2025 DEFINITION Rcn2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014863 VERSION NP_014863.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183639.1 REFERENCE 1 (residues 1 to 265) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 265) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 265) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 265) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 265) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10991. Method: conceptual translation. FEATURES Location/Qualifiers source 1..265 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..265 /product="Rcn2p" /calculated_mol_wt="29125" CDS 1..265 /gene="RCN2" /locus_tag="YOR220W" /coded_by="NM_001183639.1:1..798" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; phosphorylated in response to alpha factor; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854395" /db_xref="SGD:S000005746" ORIGIN 1 manqkqmrtq ilitdipsgk ftskwptqle ktlfkeqfpn lqshlqyytp lpflnriiii 61 fdneddtlqv fkflqellak ensgpmklfv tesllnnqhp rsrstddavs lqdnnlalle 121 dhrnkpllsi ntdpgvtgvd ssslnkggss lspdkssles ptmlklstds kpfsyqeplp 181 klsrssssts nlslnrssqt slpsqlenkd ksasgtkclf askplgltid tstrsnaasc 241 tendvnatas nppkspsitv neffh // LOCUS NP_014864 360 aa linear PLN 30-JUN-2025 DEFINITION [acyl-carrier-protein] S-malonyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014864 VERSION NP_014864.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183640.3 REFERENCE 1 (residues 1 to 360) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 360) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 360) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 360) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10992. On Jul 30, 2012 this sequence version replaced NP_014864.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..360 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..360 /product="[acyl-carrier-protein] S-malonyltransferase" /EC_number="2.3.1.39" /calculated_mol_wt="40576" Region <100..350 /region_name="FabD" /note="Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]; COG0331" /db_xref="CDD:440100" CDS 1..360 /gene="MCT1" /locus_tag="YOR221C" /coded_by="NM_001183640.3:1..1083" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity [PMID:9388293]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9388293]" /experiment="EXISTENCE:mutant phenotype:GO:0006631 fatty acid metabolic process [PMID:9388293]" /note="Predicted malonyl-CoA:ACP transferase; putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling" /db_xref="GeneID:854396" /db_xref="SGD:S000005747" ORIGIN 1 mklltfpgqg tsisisilka iirnksrefq tilsqngkes ndllqyifqn psspgsiavc 61 snlfyqlyqi lsnpsdpqdq apknmtkids pdkkdneqcy llghslgelt clsvnslfsl 121 kdlfdianfr nklmvtstek ylvahninrs nkfemwalss pratdlpqev qkllnspnll 181 sssqntisva nansvkqcvv tglvddlesl rtelnlrfpr lriteltnpy nipfhnstvl 241 rpvqeplydy iwdilkkngt htlmelnhpi ianldgnisy yihhaldrfv kcssrtvqft 301 mcydtinsgt pveidksicf gpgnviynli rrncpqvdti eytslatida yhkaaeenkd // LOCUS NP_014865 307 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 2-oxodicarboxylate carrier [Saccharomyces cerevisiae S288C]. ACCESSION NP_014865 VERSION NP_014865.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183641.1 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10993. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..307 /product="mitochondrial 2-oxodicarboxylate carrier" /calculated_mol_wt="33876" Region 8..109 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 12..293 /region_name="PTZ00169" /note="ADP/ATP transporter on adenylate translocase; Provisional" /db_xref="CDD:240302" CDS 1..307 /gene="ODC2" /locus_tag="YOR222W" /coded_by="NM_001183641.1:1..924" /experiment="EXISTENCE:direct assay:GO:0005310 dicarboxylic acid transmembrane transporter activity [PMID:11013234]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11013234]" /experiment="EXISTENCE:direct assay:GO:0006839 mitochondrial transport [PMID:11013234]" /note="Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism; ODC2 has a paralog, ODC1, that arose from the whole genome duplication" /db_xref="GeneID:854397" /db_xref="SGD:S000005748" ORIGIN 1 mssdsnakpl pfiyqfisga vagiseltvm ypldvvktrf qlevttptaa avgkqveryn 61 gvidclkkiv kkegfsrlyr gisspmlmea pkratkfacn dqyqkifknl fntnettqki 121 siaagasagm teaavivpfe likirmqdvk ssylgpmdcl kktiknegim glykgiestm 181 wrnalwnggy fgviyqvrns mpvaktkgqk trndliagai ggtvgtmlnt pfdvvksriq 241 svdavssavk kynwclpsll viyreegfra lykgfvpkvc rlapggslml vvftgmmnff 301 rdlkygh // LOCUS NP_014866 292 aa linear PLN 30-JUN-2025 DEFINITION Dsc3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014866 VERSION NP_014866.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183642.3 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10994. On Jul 30, 2012 this sequence version replaced NP_014866.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..292 /product="Dsc3p" /calculated_mol_wt="32804" Region 25..125 /region_name="Dsc3_N" /note="DSC E3 ubiquitin ligase complex subunit 3, ubiquitin-like domain; pfam10302" /db_xref="CDD:370959" Region 153..290 /region_name="Dsc3_C" /note="DSC E3 ubiquitin ligase complex subunit 3, C-terminal domain; pfam13373" /db_xref="CDD:404283" CDS 1..292 /gene="DSC3" /locus_tag="YOR223W" /coded_by="NM_001183642.3:1..879" /experiment="EXISTENCE:direct assay:GO:0000328 fungal-type vacuole lumen [PMID:21777356]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:21777356]" /experiment="EXISTENCE:direct assay:GO:0044695 Dsc E3 ubiquitin ligase complex [PMID:22681890]" /experiment="EXISTENCE:genetic interaction:GO:0140624 EGAD pathway [PMID:31368600]" /experiment="EXISTENCE:mutant phenotype:GO:0140624 EGAD pathway [PMID:31368600]" /note="Subunit of the DSC ubiquitin ligase complex; involved in the endosome and Golgi-associated degradation pathway (EGAD), contributing to proteostasis and lipid homeostasis; localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3" /db_xref="GeneID:854398" /db_xref="SGD:S000005749" ORIGIN 1 msaepllpth ngsqggevrs pdqkfivirf sdvsvrdlql nisnvpfsni nthwlrrmcr 61 elrpqqtqkr rlkfirngsi lnthskiaee lthyfdtann snvatgtsva peqnnyyihc 121 iigteeltqa elanedlkdd atpsndsmtt qaigfdrlrs vgfteqeiel lrqqfratyg 181 dleeeeerla qngnrddegh dirqleeqwm esgsgtaqgn gagggnedrf nsvpianikh 241 nkdlllgicv gfffgvfgil lmkfdglfnr rqkmaifagv ivnvmfclvr gf // LOCUS NP_014867 146 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase core subunit RPB8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014867 VERSION NP_014867.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183643.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10995. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..146 /product="DNA-directed RNA polymerase core subunit RPB8" /calculated_mol_wt="16380" Region 10..145 /region_name="RNA_pol_Rpb8" /note="RNA polymerase Rpb8; pfam03870" /db_xref="CDD:461079" CDS 1..146 /gene="RPB8" /locus_tag="YOR224C" /coded_by="NM_001183643.1:1..441" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:8288647|PMID:3905793|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:1331084|PMID:2183013|PMID:2186966]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:genetic interaction:GO:0006383 transcription by RNA polymerase III [PMID:9927738]" /experiment="EXISTENCE:physical interaction:GO:0006360 transcription by RNA polymerase I [PMID:11486042]" /experiment="EXISTENCE:physical interaction:GO:0006366 transcription by RNA polymerase II [PMID:11486042]" /experiment="EXISTENCE:physical interaction:GO:0006383 transcription by RNA polymerase III [PMID:11486042]" /note="RNA polymerase subunit ABC14.5; common to RNA polymerases I, II, and III" /db_xref="GeneID:854399" /db_xref="SGD:S000005750" ORIGIN 1 msntlfddif qvsevdpgry nkvcrieaas ttqdqckltl dinvelfpva aqdsltvtia 61 sslnledtpa ndssatrswr ppqagdrsla ddydyvmygt aykfeevskd liavyysfgg 121 llmrlegnyr nlnnlkqena yllirr // LOCUS NP_014869 156 aa linear PLN 30-JUN-2025 DEFINITION putative iron-binding protein ISU2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014869 VERSION NP_014869.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183645.3 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10996. On Jul 30, 2012 this sequence version replaced NP_014869.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..156 /product="putative iron-binding protein ISU2" /calculated_mol_wt="16799" Site order(26..29,32..33,61..62,88,90,127..128,130..131) /site_type="other" /note="trimerization site [polypeptide binding]" /db_xref="CDD:143480" Region 27..151 /region_name="iscU" /note="FeS cluster assembly scaffold IscU; TIGR01999" /db_xref="CDD:188192" Site order(61,88,131) /site_type="active" /db_xref="CDD:143480" CDS 1..156 /gene="ISU2" /locus_tag="YOR226C" /gene_synonym="NUA2" /coded_by="NM_001183645.3:1..471" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10468587|PMID:15143178]" /experiment="EXISTENCE:genetic interaction:GO:0002098 tRNA wobble uridine modification [PMID:17283054]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:10468587]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:15143178|PMID:10588895]" /note="Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant" /db_xref="GeneID:854401" /db_xref="SGD:S000005752" ORIGIN 1 mfarlanpah fkpltgshit raakrlyhpk vidhytnprn vgsmdkslan vgtgivgapa 61 cgdviklqiq vndksgiien vkfktfgcgs aiasssymte lvrgmsldea vkiknteiak 121 elslppvklh csmlaedaik aaikdyktkr npsvlh // LOCUS NP_014870 1246 aa linear PLN 30-JUN-2025 DEFINITION Her1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014870 VERSION NP_014870.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183646.1 REFERENCE 1 (residues 1 to 1246) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1246) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1246) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1246) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1246) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10997. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1246 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1246 /product="Her1p" /calculated_mol_wt="139327" CDS 1..1246 /gene="HER1" /locus_tag="YOR227W" /coded_by="NM_001183646.1:1..3741" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0007029 endoplasmic reticulum organization [PMID:18667535]" /note="hypothetical protein; required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments; HER1 has a paralog, GIP3, that arose from the whole genome duplication" /db_xref="GeneID:854402" /db_xref="SGD:S000005753" ORIGIN 1 mssklkytdi dvpldwlykg krrnrtksaa strtseattt svkktatlps taavptktia 61 spqrplsgqn vnnelsnskp avsaekvsqq gqvptrrtrs hsvsygllqk knnnddttds 121 pkisrirtaq dqpvketkss tlaepivskk grsrsssist slnerskksl fgslfgrrps 181 ttpshvverp lssqndhkks telppidtrq skistptstp ttasskpsss ggnrhsdgsl 241 tskllsiphn iletsstnfn ahhhiqshhs sgreqdsphs essdlppile kettqkqlqk 301 vskvnlkrvt iavqefnsdp pqqlpsrkpk rgnvlipedm isapplislg itnssdqssf 361 qsnispsysk dskeyklale nfkkaakeae khqkdayyva ermaqevany karqlktspl 421 tgatnsaads atdqesssld arasklhidk pinvgahpfe thqddnikys shleqtldva 481 ytrcchlrei lpipstlrqv kgktaplqtl kflnpkptlv dilsfcdfia itpihniifd 541 nvslthdmfk ivicslvtsp vveklglrnv vineqswkll ckfllqnktl ikldisqtka 601 rtdlndsnyr dqmdwelfce vlrnregrpl eelllnglrf dkmsfshfkn illtfaqmnp 661 knpirlgman vefstecfdf lfnwmseynv qgvdlaynnl eslakrmikk larlpykhle 721 yftlnstnit svddmsyilk ylsrlpsikf ldlsnlpqlf pgiltsgyky fpqfpqlkri 781 hfdfddlsik ettmlvsila kcetlshvsl igqspmpdas kisdstdepd kskdekkeqi 841 vfmrntlwas lyafvrdshn lvsldvdydq vpdeiqsria lclmhnmkri mdssfkldel 901 tvqddlifdg slitetaeev lkrlndksll qndvgkkyll kkyfekmekv hhnvqntids 961 mfekrksgel plqekenllr lllleknlsn ildifasmpn iadvvpfska dnsfpnigds 1021 tvsanyndgi rpslkhldsd rlindvsipe ndssirphlm atdsgriidv ttgkallfks 1081 ssntslagkr qeeeegelhk wgvfvqhqss rhnsglpssa nssrisgslt pdssvaggkk 1141 gessrtsgtr pkilpkiptg aelrdaiika kgidsvddli knvtsekvgl eslygdelns 1201 rspsndslqe sqqkaplqrp lvedetvtkk ydkllndlsn vrhskt // LOCUS NP_014871 302 aa linear PLN 30-JUN-2025 DEFINITION Mcp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014871 VERSION NP_014871.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183647.3 REFERENCE 1 (residues 1 to 302) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 302) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 302) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 302) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 302) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10998. On Jul 30, 2012 this sequence version replaced NP_014871.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..302 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..302 /product="Mcp1p" /calculated_mol_wt="33858" Region 67..158 /region_name="MCP1_TM" /note="MDM10-complementing protein 1, transmembrane domain; pfam07950" /db_xref="CDD:400346" Region 182..278 /region_name="MCP1_TM" /note="MDM10-complementing protein 1, transmembrane domain; pfam07950" /db_xref="CDD:400346" CDS 1..302 /gene="MCP1" /locus_tag="YOR228C" /coded_by="NM_001183647.3:1..909" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:23781023|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:23781023]" /experiment="EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:23781023]" /experiment="EXISTENCE:genetic interaction:GO:0055088 lipid homeostasis [PMID:23781023]" /note="Mitochondrial hypothetical protein involved in lipid homeostasis; integral membrane protein that localizes to the mitochondrial outer membrane; involved in mitochondrial morphology; interacts genetically with MDM10, and other members of the ERMES complex; contains five predicted transmembrane domains" /db_xref="GeneID:854403" /db_xref="SGD:S000005754" ORIGIN 1 miklhevppe pvdpaslphd vnahspegdg npdkrkkifg ipypfsrssc rrflwncqki 61 svlpmalyfp lhaantlitp avspdsapdd vlmmvreilp sittkllvag itlhvsagvl 121 lrivnnwnkp rrnrhrhlki saeqdlsqds igltggisgy lfglyktfri ppqvisgyil 181 vpvliyhlli mkwvpnsist evdfasikql lssknrwwkw lgglvplail lesgvyhigs 241 glcryfgvrk mtsrkkwsta inlltlvgfv slirlmkeds tklgpnqfes ifkkirlllh 301 vn // LOCUS NP_014872 467 aa linear PLN 30-JUN-2025 DEFINITION transcriptional modulator [Saccharomyces cerevisiae S288C]. ACCESSION NP_014872 VERSION NP_014872.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183648.1 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA10999. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..467 /product="transcriptional modulator" /calculated_mol_wt="51820" Region <221..382 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 251..285 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 292..343 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 354..399 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..467 /gene="WTM2" /locus_tag="YOR229W" /coded_by="NM_001183648.1:1..1404" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:16980392]" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9234739]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:9234739]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16980392]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9234739]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16980392]" /experiment="EXISTENCE:genetic interaction:GO:0051321 meiotic cell cycle [PMID:9234739]" /experiment="EXISTENCE:genetic interaction:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:9234739]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:16980392]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:16980392]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:16452505]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16980392]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:16452505]" /note="Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; relocalizes to the cytosol in response to hypoxia; WTM2 has a paralog, UME1, that arose from the whole genome duplication" /db_xref="GeneID:854404" /db_xref="SGD:S000005755" ORIGIN 1 makskssqga sgarrkpaps lyqhissfkp qfstrvddvl hfsktltwrs eiipdkskgt 61 lttsllysqg sdiyeidttl plktfydddd dddnddddee gngktksaat pnpeygdafq 121 dvegkplrpk wiyqgetvak mqylessdds taiamskngs lawfrdeikv pvhivqemmg 181 patryssihs ltrpgslavs dfdvstnmdt vvksqsngye edsilkiidn sdrpgdilrt 241 vhvpgtnvah svrffnnhlf ascsddnilr fwdtrtadkp lwtlsepkng rltsfdssqv 301 tenlfvtgfs tgviklwdar avqlattdlt hrqngeepiq neiaklfhsg gdsvvdilfs 361 qtsatefvtv ggtgnvyhwd meysfsrndd dnedevrvaa peelqgqclk ffhtggtrrs 421 snqfgkrntv alhpvindfv gtvdsdslvt aykpflasdf igrgydd // LOCUS NP_014873 437 aa linear PLN 30-JUN-2025 DEFINITION transcriptional modulator [Saccharomyces cerevisiae S288C]. ACCESSION NP_014873 VERSION NP_014873.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183649.3 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11000. On Jul 30, 2012 this sequence version replaced NP_014873.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..437 /product="transcriptional modulator" /calculated_mol_wt="48252" Region <198..304 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 225..262 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 270..311 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 395..429 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..437 /gene="WTM1" /locus_tag="YOR230W" /coded_by="NM_001183649.3:1..1314" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9234739]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9234739|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16980392]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9234739]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16980392]" /experiment="EXISTENCE:genetic interaction:GO:0051321 meiotic cell cycle [PMID:9234739]" /experiment="EXISTENCE:genetic interaction:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:9234739]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:16432237]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16980392]" /experiment="EXISTENCE:mutant phenotype:GO:0051457 maintenance of protein location in nucleus [PMID:16452505]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:16452505]" /experiment="EXISTENCE:physical interaction:GO:0006606 protein import into nucleus [PMID:16432237]" /note="Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; acts as a nuclear anchor to retain the ribonucleotide reductase small subunit heterodimer, Rnr2p-Rnr4p, in the nucleus when cells are not in S phase; contains WD repeats" /db_xref="GeneID:854405" /db_xref="SGD:S000005756" ORIGIN 1 mpkkvwksst pstyehissl rpkfvsrvdn vlhqrksltf snvvvpdkkn ntltssviys 61 qgsdiyeidf avplqeaase pvkdygdafe gientslspk fvyqgetvsk mayldktget 121 tllsmskngs lawfkegikv pihivqelmg patsyasihs ltrpgdlpek dfslaisdfg 181 isndtetivk sqsngdeeds ilkiidnagk pgeilrtvhv pgttvthtvr ffdnhifasc 241 sddnilrfwd trtsdkpiwv lgepkngklt sfdcsqvsnn lfvtgfstgi iklwdaraae 301 aattdltyrq ngedpiqnei anfyhaggds vvdvqfsats ssefftvggt gniyhwntdy 361 slskynpddt iappqdatee sqtkslrflh kggsrrspkq igrrntaawh pvienlvgtv 421 dddslvsiyk pyteese // LOCUS NP_014874 508 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase kinase MKK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014874 VERSION NP_014874.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183650.1 REFERENCE 1 (residues 1 to 508) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 508) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 508) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 508) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 508) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11001. Method: conceptual translation. FEATURES Location/Qualifiers source 1..508 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..508 /product="mitogen-activated protein kinase kinase MKK1" /EC_number="2.7.12.2" /calculated_mol_wt="56589" Region 219..506 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(227..230,233,235,248,250,281,299..302,349,353..354, 356,366..367) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..508 /gene="MKK1" /locus_tag="YOR231W" /gene_synonym="SSP32" /coded_by="NM_001183650.1:1..1527" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12361575]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12361575|PMID:23924898]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:23924898|PMID:12361575]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12361575]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:8386320]" /experiment="EXISTENCE:genetic interaction:GO:0000425 pexophagy [PMID:20385774]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:8386320]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:8386320]" /note="MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication" /db_xref="GeneID:854406" /db_xref="SGD:S000005757" ORIGIN 1 maslfrppes akcnpnsprl klpllrnnqv denniyltsn gssttayssh tpepltssts 61 tlfsqtrlhp sdssmtlntm kkrpappslp slsinsqskc ktlpelvpia dvsdgkhdlg 121 lkqrviaene lsgnsdltps smaspfshtn tsspylrndl snsvgsdfsn lisayeqsss 181 piksssqpks ssesyidlns vrdvdqlden gwkyanlkdr ietlgilgeg aggsvskckl 241 kngskifalk vintlntdpe yqkqifrelq fnrsfqseyi vryygmftdd enssiyiame 301 ymggrsldai yknllerggr isekvlgkia eavlrglsyl hekkvihrdi kpqnillnen 361 gqvklcdfgv sgeavnslat tftgtsfyma periqgqpys vtsdvwslgl tilevangkf 421 pcssekmaan iapfellmwi ltftpelkde pesniiwsps fksfidyclk kdsrerpspr 481 qminhpwikg qmkknvnmek fvrkcwkd // LOCUS NP_014875 228 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial nucleotide exchange factor MGE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014875 VERSION NP_014875.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183651.3 REFERENCE 1 (residues 1 to 228) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 228) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 228) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 228) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11002. On Jul 30, 2012 this sequence version replaced NP_014875.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..228 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..228 /product="mitochondrial nucleotide exchange factor MGE1" /calculated_mol_wt="25935" Region 83..222 /region_name="GrpE" /note="nucleotide exchange factor GrpE; cd00446" /db_xref="CDD:271355" Region 83..132 /region_name="2-helical coiled coil" /note="2-helical coiled coil [structural motif]" /db_xref="CDD:271355" Site order(84,87..88,91..92,94..95,98..100,102,105..106, 109..110,113..114,116..117,120..122,124..128,130..131, 152..153,155..157,160,166..167) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:271355" Site order(100,108,130,133,179,181..182,184..188,204,213,217, 219,222) /site_type="other" /note="Hsp70 (ATPase domain) interactions [polypeptide binding]" /db_xref="CDD:271355" Region 152..167 /region_name="2-helical coiled coil" /note="2-helical coiled coil [structural motif]" /db_xref="CDD:271355" CDS 1..228 /gene="MGE1" /locus_tag="YOR232W" /gene_synonym="YGE1" /coded_by="NM_001183651.3:1..687" /experiment="EXISTENCE:direct assay:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:9048947|PMID:12756240]" /experiment="EXISTENCE:direct assay:GO:0001405 PAM complex, Tim23 associated import motor [PMID:14517234|PMID:14638855]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:11914276|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:8022808]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:9973563]" /experiment="EXISTENCE:mutant phenotype:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:8918457]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:8022808]" /note="Mitochondrial matrix cochaperone; nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; acts as oxidative sensor to regulate mitochondrial Ssc1p; in presence of oxidative stress, dimeric Mge1p becomes a monomer and unable to regulate Ssc1p function; homolog of E. coli GrpE and human Mge1 (GRPEL1), which also responds to oxidative stress" /db_xref="GeneID:854407" /db_xref="SGD:S000005758" ORIGIN 1 mrafsaatvr attrksfipm aprtpfvtps ftknvgsmrr mrfysdeaks eeskennedl 61 teeqseikkl esqlsaktke aselkdrllr svadfrnlqq vtkkdiqkak dfalqkfakd 121 llesvdnfgh alnafkeedl qkskeisdly tgvrmtrdvf entlrkhgie kldplgepfd 181 pnkheatfel pqpdkepgtv fhvqqlgftl ndrvirpakv givkgeen // LOCUS NP_014876 800 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase KIN4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014876 VERSION NP_014876.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183652.1 REFERENCE 1 (residues 1 to 800) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 800) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 800) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 800) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 800) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11003. Method: conceptual translation. FEATURES Location/Qualifiers source 1..800 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..800 /product="putative serine/threonine protein kinase KIN4" /EC_number="2.7.11.1" /calculated_mol_wt="89957" Region 44..313 /region_name="STKc_Kin4" /note="Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; cd14076" /db_xref="CDD:270978" Site order(52..56,60,78,80,113,129..132,136,138..139,141, 174..175,177,179..180,182,192..193,196,211..215,217, 248..251) /site_type="active" /db_xref="CDD:270978" Site order(52..55,60,78,80,113,129..132,136,179..180,182, 192..193) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270978" Site order(136,138..139,141,175,177,179,196,211..215,217, 248..251) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270978" Site order(192..204,205..215) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270978" CDS 1..800 /gene="KIN4" /locus_tag="YOR233W" /gene_synonym="KIN3; KIN31" /coded_by="NM_001183652.1:1..2403" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:17967947]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:16039590]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:16039591]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:16039591]" /experiment="EXISTENCE:genetic interaction:GO:0000011 vacuole inheritance [PMID:37509134]" /experiment="EXISTENCE:genetic interaction:GO:0045033 peroxisome inheritance [PMID:37509134]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:24850890]" /experiment="EXISTENCE:mutant phenotype:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:16039590|PMID:16039591]" /experiment="EXISTENCE:mutant phenotype:GO:0045033 peroxisome inheritance [PMID:37509134]" /experiment="EXISTENCE:mutant phenotype:GO:0071988 protein localization to spindle pole body [PMID:24850890]" /note="Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint (SPOC) is activated; regulates peroxisomal transport and vacuolar inheritance along with Frk1p; protects the peroxisomal Myo2p receptor Inp2p from degradation in mother cells along with Frk1p; localizes asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication" /db_xref="GeneID:854408" /db_xref="SGD:S000005759" ORIGIN 1 masvpkrhty ggnvvtdrdr hslqrnneil hpihknqrkh atfgpyiigs tlgegefgkv 61 klgwtkasss nevpkqvaik lirrdtikkd adkeikiyre inalkhlthp niiyleevlq 121 nskyigivle fvsggefyky iqrkrrlkes sacrlfaqli sgvnymhykg lvhrdlklen 181 llldkhenlv itdfgfvnef fednelmkts cgspcyaape lvvstkayea rkadvwscgv 241 ilyamlagyl pwdddhenpt gddiarlyky itqtplkfpe yitpiprdll rrilvpnprr 301 rinlqtikrh vwlkpheafl siqpnywdeh lqkerpkppn kgdvgrhsty sssassysks 361 rdrnsliies tleqhrmspq latsrpaspt fstgskvvln dtkndmkesn ingertsasc 421 rytrdskgng qtqieqvsar hssrgnkhts vaglvtipgs pttartrnap sskltehvkd 481 ssqtsftqee fhrignyhvp rsrprptsyy pglsrntadn sladipvnkl gsngrltdak 541 dpvplnaihd tnkatisnns imllsegpaa ktspvdyhya igdlnhgdkp itevidkink 601 dlthkaaeng fpresidpes tstilvtkep tnstdedhve sqlenvghss nksdassdkd 661 skkiyekkrf sfmslyssln gsrstvesrt skgnappvss rnpsgqsnrs nikitqqqpr 721 nlsdrvpnpd kkindnrird napsyaesen pgrsvrasvm vstlreenrs elsnegnnve 781 aqtstarkvl nffkrrsmrv // LOCUS NP_014877 107 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL33 RPL33B [Saccharomyces cerevisiae S288C]. ACCESSION NP_014877 VERSION NP_014877.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183653.3 REFERENCE 1 (residues 1 to 107) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 107) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 107) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 107) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11004. On Jul 30, 2012 this sequence version replaced NP_014877.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..107 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..107 /product="60S ribosomal protein eL33 RPL33B" /calculated_mol_wt="12037" Region 7..100 /region_name="Ribosomal_L35Ae" /note="Ribosomal protein L35Ae; pfam01247" /db_xref="CDD:460132" CDS 1..107 /gene="RPL33B" /locus_tag="YOR234C" /gene_synonym="RPL37B" /coded_by="NM_001183653.3:1..324" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L33B; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33B has a paralog, RPL33A, that arose from the whole genome duplication" /db_xref="GeneID:854409" /db_xref="SGD:S000005760" ORIGIN 1 maeshrlyvk gkhlsyqrsk rvnnpnvsli kiegvatpqe aqfylgkria yvyraskevr 61 gskirvmwgk vtrthgnsgv vratfrnnlp aktfgasvri flypsni // LOCUS NP_001335817 104 aa linear PLN 30-JUN-2025 DEFINITION Irc13p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335817 VERSION NP_001335817.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348879.1 REFERENCE 1 (residues 1 to 104) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 104) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 104) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 104) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 104) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80337. Method: conceptual translation. FEATURES Location/Qualifiers source 1..104 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..104 /product="Irc13p" /calculated_mol_wt="12259" CDS 1..104 /gene="IRC13" /locus_tag="YOR235W" /coded_by="NM_001348879.1:1..315" /note="hypothetical protein; conserved across S. cerevisiae strains; null mutant displays increased levels of spontaneous Rad52 foci" /db_xref="GeneID:854410" /db_xref="SGD:S000005761" ORIGIN 1 mglyrpskff hppiphipft inpdffsfhi qrlkakanpe nflicfpppd iykgfvfccq 61 ldlvhlfsyv fflfllkicv dvlqyviypk hfthkkpgfe nysi // LOCUS NP_014879 211 aa linear PLN 30-JUN-2025 DEFINITION dihydrofolate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014879 VERSION NP_014879.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183655.1 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11005. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..211 /product="dihydrofolate reductase" /EC_number="1.5.1.3" /calculated_mol_wt="24130" Region 8..208 /region_name="DHFR" /note="Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; cd00209" /db_xref="CDD:238127" Site order(11,29,34,74,122,128,141) /site_type="other" /note="folate binding site [chemical binding]" /db_xref="CDD:238127" Site order(13,21,58..60,81,123..126) /site_type="other" /note="NADP+ binding site [chemical binding]" /db_xref="CDD:238127" CDS 1..211 /gene="DFR1" /locus_tag="YOR236W" /coded_by="NM_001183655.1:1..636" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0004146 dihydrofolate reductase activity [PMID:2838385]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004146 dihydrofolate reductase activity [PMID:1427091|PMID:2827121]" /experiment="EXISTENCE:mutant phenotype:GO:0046452 dihydrofolate metabolic process [PMID:1427091]" /experiment="EXISTENCE:mutant phenotype:GO:0046654 tetrahydrofolate biosynthetic process [PMID:1427091]" /note="Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism; mutation is functionally complemented by human DHFR" /db_xref="GeneID:854411" /db_xref="SGD:S000005762" ORIGIN 1 maggkipivg ivaclqpemg igfrgglpwr lpsemkyfrq vtsltkdpnk knalimgrkt 61 wesippkfrp lpnrmnviis rsfkddfvhd kersivqsns lanaimnles nfkehleriy 121 vigggevysq ifsitdhwli tkinpldkna tpamdtflda kkleevfseq dpaqlkeflp 181 pkvelpetdc dqrysleekg ycfeftlynr k // LOCUS NP_014880 434 aa linear PLN 30-JUN-2025 DEFINITION oxysterol-binding protein related protein HES1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014880 VERSION NP_014880.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183656.3 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11006. On Jul 30, 2012 this sequence version replaced NP_014880.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..434 /product="oxysterol-binding protein related protein HES1" /calculated_mol_wt="49374" Region 12..365 /region_name="Oxysterol_BP" /note="Oxysterol-binding protein; pfam01237" /db_xref="CDD:460126" CDS 1..434 /gene="HES1" /locus_tag="YOR237W" /gene_synonym="OSH5" /coded_by="NM_001183656.3:1..1305" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008142 oxysterol binding [PMID:16408938]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:20008566]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]" /experiment="EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:16585271]" /experiment="EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:16585271]" /note="Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); SWAT-GFP and mCherry fusion proteins localize to the bud neck and vacuolar membrane; HES1 has a paralog, KES1, that arose from the whole genome duplication" /db_xref="GeneID:854412" /db_xref="SGD:S000005763" ORIGIN 1 msqhassssw tsflksissf ngdlsslsap pfilsptslt efsqywaehp alflepslid 61 genykdhcpf dpnveskeva qmlavvrwfi stlrsqycsr sesmgsekkp lnpflgevfv 121 gkwkndehpe fgetvllseq vshhppmtaf sifnekndvs vqgynqiktg ftktltltvk 181 pyghvilkik detylittpp lhiegilvas pfvelggrsf iqssngmlcv iefsgrgyft 241 gkknsfkari yrspqehshk enalylisgq wsgvstiikk dsqvshqfyd ssetptehll 301 vkpieeqhpl esrrawkdva eairqgnism ikktkeelen kqralreqer vkgvewqrrw 361 fkqvdymnen tsndvekase ddafrklask lqlsvknvps gtliggkddk kdvstalhwr 421 fdknlwmren eiti // LOCUS NP_014881 303 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR238W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014881 VERSION NP_014881.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183657.1 REFERENCE 1 (residues 1 to 303) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 303) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 303) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 303) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 303) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11007. On Oct 2, 2003 this sequence version replaced NP_014881.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..303 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..303 /product="uncharacterized protein" /calculated_mol_wt="35079" CDS 1..303 /locus_tag="YOR238W" /coded_by="NM_001183657.1:1..912" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:854413" /db_xref="SGD:S000005764" ORIGIN 1 mdekvelilv pchsiwksss hpsdnsvnlg qlpeywhlap fqyegndhla fikhgltaik 61 lllqrfdtat vifsgsqtkk eagaiseaqs yyflfeklir yvmsndnidv pnfdnelrll 121 lkevknllss qnvnvdelfy ggsitteefs ldsfdnliys iyrfeevnkk fpqkitiigf 181 afkmprfisc hakaidypqs nityigidpk panynqtqls kyyddlvqme dknalslfss 241 dwyatkdrll tkkrsrnpfn rtapyaqnif ckengkrieg ieddeeyfet kikckmpwss 301 prq // LOCUS NP_014882 628 aa linear PLN 30-JUN-2025 DEFINITION tRNA(Thr) (cytosine(32)-N(3))-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014882 VERSION NP_014882.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183658.6 REFERENCE 1 (residues 1 to 628) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 628) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 628) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 628) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 628) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11008. On Jul 30, 2012 this sequence version replaced NP_014882.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..628 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..628 /product="tRNA(Thr) (cytosine(32)-N(3))-methyltransferase" /EC_number="2.1.1.268" /calculated_mol_wt="71355" Region <53..>247 /region_name="2A1904" /note="K+-dependent Na+/Ca+ exchanger; TIGR00927" /db_xref="CDD:273344" Region 438..543 /region_name="Methyltransf_12" /note="Methyltransferase domain; pfam08242" /db_xref="CDD:400515" Site order(440..446,466..467,496..498,515) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..628 /gene="ABP140" /locus_tag="YOR239W" /gene_synonym="TRM140; YOR240W" /coded_by="join(NM_001183658.6:1..831, NM_001183658.6:833..1888)" /experiment="EXISTENCE:direct assay:GO:0005884 actin filament [PMID:9467951]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:9467951]" /experiment="EXISTENCE:direct assay:GO:0032432 actin filament bundle [PMID:11805329]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:9467951]" /experiment="EXISTENCE:direct assay:GO:0052735 tRNA (cytidine-3-)-methyltransferase activity [PMID:21518804|PMID:21518805]" /experiment="EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:21518805|PMID:21518804]" /experiment="EXISTENCE:mutant phenotype:GO:0052735 tRNA (cytidine-3-)-methyltransferase activity [PMID:21518804]" /ribosomal_slippage="" /note="AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) binding motif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift" /db_xref="GeneID:854414" /db_xref="SGD:S000005765" ORIGIN 1 mgvadlikkf esiskeegda tvdtnssskp lksndetkel hqqestavpq evdvneefen 61 epetinssrt aekpletnlp kpetneedee egsmsenkiy skgenadinv ndfqeykeme 121 ntgaevlass veesdaiqeg vaeetegiat pkqkeneknd eseeesanna sepaeeysqs 181 eedadieqsn gketenaena sqqandgsts tttsknkkkk nkkknkkkrn gnvntnanvd 241 dstktgendd ttgdttsstt saiqevndle vvddsclgid qqhnrehlka ltqdvkeetl 301 eniahegrgd ntgdqnavek sdfeksdteg srigrdlpfe fgkrnltees dvwdhnawdn 361 vewgeeqvqq aeekikeqfk hpvpefdkkl ynenparywd ifyknnkenf fkdrkwlqie 421 fpilyastrk daepvtifei gcgagntffp ilkdnenenl riiaadfapr avelvknseq 481 fnpkyghatv wdlanpdgnl pdgvephsvd iavmifvfsa lapnqwdqam dnlhkilkpg 541 gkiifrdyga ydltqvrfkk nrileenfyv rgdgtrvyff seeklreift kkyflenkig 601 tdrrllvnrk rqlkmyrcwv qavfdvpq // LOCUS NP_014884 548 aa linear PLN 30-JUN-2025 DEFINITION tetrahydrofolate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014884 VERSION NP_014884.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183660.1 REFERENCE 1 (residues 1 to 548) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 548) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 548) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 548) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 548) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11009. Method: conceptual translation. FEATURES Location/Qualifiers source 1..548 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..548 /product="tetrahydrofolate synthase" /EC_number="6.3.2.17" /calculated_mol_wt="62021" Region 100..542 /region_name="folC" /note="folylpolyglutamate synthase/dihydrofolate synthase; TIGR01499" /db_xref="CDD:273659" CDS 1..548 /gene="MET7" /locus_tag="YOR241W" /gene_synonym="MET23" /coded_by="NM_001183660.1:1..1647" /experiment="EXISTENCE:direct assay:GO:0004326 tetrahydrofolylpolyglutamate synthase activity [PMID:10775416]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10775416]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10775416]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006730 one-carbon metabolic process [PMID:10775416]" /note="Folylpolyglutamate synthetase; catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854415" /db_xref="SGD:S000005767" ORIGIN 1 mhkgkknypn litsfrmnlk kiilnhdrfs hperwktnal lrftfvyikf lfdlmiiknp 61 lrmvgktyrd avtalnslqs nyanimairq tgdrkntmtl lemhewsrri gysasdfnkl 121 nivhitgtkg kgstaaftss ilgqykeqlp riglytsphl ksvreririn gepiseekfa 181 kyffevwdrl dsttssldkf phmipgskpg yfkfltllsf htfiqedcks cvyevgvgge 241 ldstniiekp ivcgvtllgi dhtfmlgdti eeiawnkggi fksgapaftv ekqppqglti 301 lkeraeerkt tltevppfkq lenvklgiag efqksnasla vmlaseilht snileekikc 361 ssnasipekf iiglqntkwe grcqvlekgk nvwyidgaht kdsmvaastw frdmvrlskr 421 kkillfnqqs rdanalvnnl yssvspeitf ddvifttnvt wksgsysadl vsmntsqedv 481 eklkvqeslv knwnkiddnr akthvtasie eanelietly depadifvtg slhlvggllv 541 vfdridvk // LOCUS NP_014885 371 aa linear PLN 30-JUN-2025 DEFINITION Ssp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014885 VERSION NP_014885.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183661.3 REFERENCE 1 (residues 1 to 371) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 371) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 371) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 371) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 371) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11010. On Jul 30, 2012 this sequence version replaced NP_014885.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..371 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..371 /product="Ssp2p" /calculated_mol_wt="42969" Region 164..240 /region_name="RRM_SF" /note="RNA recognition motif (RRM) superfamily; cl17169" /db_xref="CDD:473069" Region 290..369 /region_name="RRM_Ssp2_like" /note="RNA recognition motif (RRM) found in yeast sporulation-specific protein 2 (Ssp2) and similar protein; cd12419" /db_xref="CDD:409853" CDS 1..371 /gene="SSP2" /locus_tag="YOR242C" /coded_by="NM_001183661.3:1..1116" /experiment="EXISTENCE:direct assay:GO:0005619 ascospore wall [PMID:12073037]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:28223369]" /experiment="EXISTENCE:direct assay:GO:0031954 positive regulation of protein autophosphorylation [PMID:23207907]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:17110477]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:12073037]" /experiment="EXISTENCE:mutant phenotype:GO:0031954 positive regulation of protein autophosphorylation [PMID:23207907]" /note="Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; expression controlled by a tightly regulated middle-meiotic promoter that is activated by Ndt80p; translation of SSP2 mRNA is delayed, such that the mRNA is present as nuclear divisions are taking place but is not engaged by ribosomes until relatively late in meiotic development" /db_xref="GeneID:854416" /db_xref="SGD:S000005768" ORIGIN 1 myknyysnte vykkhkdsgs lrkkalrsrr ssffsffnds sssngnefig frrfakaylf 61 greigscgtd sytpvganvn krrlkkedkn dqqlwkrqhh sqgcffpidd dsnkqteaav 121 nkfyengeyv nqdlifkgkv yseesevvde ktagsqnpal lktrsislnd iprgtgissv 181 lsqvrggsle riivyrydtp erslhkvdlf flnyegaqsf mryaktnifk vngvqlkpew 241 iflestyeni mkeqsvnrii eeekfisrcl ivkkssttam pnksnlnkgq tlenidiqel 301 ekdfqnfgev leitpivsrk lcvsiffydi ssamrameey eqkgsylynk yfktwtiwyg 361 kditdqpcid l // LOCUS NP_014886 676 aa linear PLN 30-JUN-2025 DEFINITION pseudouridine synthase PUS7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014886 VERSION NP_014886.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183662.1 REFERENCE 1 (residues 1 to 676) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 676) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 676) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 676) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11011. Method: conceptual translation. FEATURES Location/Qualifiers source 1..676 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..676 /product="pseudouridine synthase PUS7" /EC_number="5.4.99.27" /calculated_mol_wt="76872" Region 217..659 /region_name="PseudoU_synth_ScPUS7" /note="Pseudouridine synthase, TruD family; cd02576" /db_xref="CDD:211341" Site order(253..256,652) /site_type="active" /note="probable active site [active]" /db_xref="CDD:211341" CDS 1..676 /gene="PUS7" /locus_tag="YOR243C" /coded_by="NM_001183662.1:1..2031" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:25219674]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25219674]" /experiment="EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:12682021]" /experiment="EXISTENCE:direct assay:GO:0031120 snRNA pseudouridine synthesis [PMID:12682021]" /experiment="EXISTENCE:mutant phenotype:GO:0000455 enzyme-directed rRNA pseudouridine synthesis [PMID:18332121]" /experiment="EXISTENCE:mutant phenotype:GO:0009982 pseudouridine synthase activity [PMID:18332121|PMID:12682021]" /experiment="EXISTENCE:mutant phenotype:GO:0031119 tRNA pseudouridine synthesis [PMID:14561887]" /experiment="EXISTENCE:mutant phenotype:GO:0031120 snRNA pseudouridine synthesis [PMID:12682021|PMID:14561887]" /experiment="EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25192136|PMID:25219674]" /note="Pseudouridine synthase; catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); also pseudouridylates some mRNAs; relocates from nucleus to cytoplasm during heat shock and differentially modifies some mRNAs during heat shock; conserved in archaea, vertebrates, and some bacteria" /db_xref="GeneID:854417" /db_xref="SGD:S000005769" ORIGIN 1 msdsseatvk rpldahvgps enaakklkie qrtqadgihe advgitlfls pelpgfrgqi 61 kqrytdflvn eidqegkvih ltdkgfkmpk kpqrskeevn aekeseaarr qefnvdpelr 121 nqlveifgee dvlkiesvyr tankmetakn fedksvrtki hqllreafkn elesvttdtn 181 tfkiarsnrn srtnkqekin qtrdangven wgygpskdfi hftlhkenkd tmeavnvitk 241 llrvpsrvir yagtkdrrav tcqrvsiski gldrlnalnr tlkgmiigny nfsdaslnlg 301 dlkgnefvvv irdvttgnse vsleeivsng ckslsengfi nyfgmqrfgt fsisthtigr 361 elllsnwkka aelilsdqdn vlpkskeark iwaetkdaal alkqmprqcl aenallysls 421 nqrkeedgty senayytaim kiprnlrtmy vhayqsyvwn siaskrielh glklvvgdlv 481 idtsekspli sgiddedfde dvreaqfira kavtqedids vkytmedvvl pspgfdvlyp 541 sneelkqlyv dilkadnmdp fnmrrkvrdf slagsyrtvi qkpksleyri ihyddpsqql 601 vntdldilnn trakesgqky mkakldrymp dkggektavv lkfqlgtsay atmalrelmk 661 letsrrgdmc dvkeni // LOCUS NP_014887 445 aa linear PLN 30-JUN-2025 DEFINITION NuA4 histone acetyltransferase complex catalytic subunit ESA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014887 VERSION NP_014887.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183663.3 REFERENCE 1 (residues 1 to 445) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 445) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 445) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 445) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11012. On Jul 30, 2012 this sequence version replaced NP_014887.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..445 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..445 /product="NuA4 histone acetyltransferase complex catalytic subunit ESA1" /EC_number="2.3.1.48" /calculated_mol_wt="52482" Region 16..431 /region_name="SAS2" /note="Histone acetyltransferase (MYST family) [Chromatin structure and dynamics]; COG5027" /db_xref="CDD:227360" CDS 1..445 /gene="ESA1" /locus_tag="YOR244W" /gene_synonym="KAT5; TAS1" /coded_by="NM_001183663.3:1..1338" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0003712 transcription coregulator activity [PMID:31699900]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:17274630]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0006354 DNA-templated transcription elongation [PMID:15949446]" /experiment="EXISTENCE:direct assay:GO:0010485 histone H4 acetyltransferase activity [PMID:12110674]" /experiment="EXISTENCE:direct assay:GO:0032777 piccolo histone acetyltransferase complex [PMID:12782659]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911|PMID:10911987]" /experiment="EXISTENCE:direct assay:GO:0140068 histone crotonyltransferase activity [PMID:31699900]" /experiment="EXISTENCE:genetic interaction:GO:0000183 rDNA heterochromatin formation [PMID:16436512]" /experiment="EXISTENCE:genetic interaction:GO:0006281 DNA repair [PMID:25628362]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:19822662]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:16436512]" /experiment="EXISTENCE:mutant phenotype:GO:0004402 histone acetyltransferase activity [PMID:10487762]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:12353039]" /experiment="EXISTENCE:mutant phenotype:GO:0006354 DNA-templated transcription elongation [PMID:15949446]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11036083]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:22539722]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:19822662]" /experiment="EXISTENCE:mutant phenotype:GO:0034212 protein N-acetyltransferase activity [PMID:23050233]" /experiment="EXISTENCE:mutant phenotype:GO:0051726 regulation of cell cycle [PMID:10082517]" /note="Catalytic subunit of the histone acetyltransferase complex (NuA4); acetylates four conserved internal lysines of histone H4 N-terminal tail and can acetylate histone H2A; master regulator of cellular acetylation balance; required for cell cycle progression and transcriptional silencing at the rDNA locus and regulation of autophagy; human ortholog TIP60/KAT5 is implicated in cancer and other diseases, functionally complements lethality of the esa1 null mutation" /db_xref="GeneID:854418" /db_xref="SGD:S000005770" ORIGIN 1 mshdgkeepg iakkinsvdd iiikcqcwvq kndeerlaei lsintrkapp kfyvhyvnyn 61 krldewittd rinldkevly pklkatdedn kkqkkkkatn tsetpqdslq dgvdgfsren 121 tdvmdldnln vqgikdenis hedeikklrt sgsmtqnphe varvrnlnri imgkyeiepw 181 yfspypielt dedfiyiddf tlqyfgskkq yeryrkkctl rhppgneiyr ddyvsffeid 241 grkqrtwcrn lcllsklfld hktlyydvdp flfycmtrrd elghhlvgyf skekesadgy 301 nvaciltlpq yqrmgygkll iefsyelskk enkvgspekp lsdlgllsyr aywsdtlitl 361 lvehqkeiti deissmtsmt ttdilhtakt lnilryykgq hiiflnedil drynrlkakk 421 rrtidpnrli wkppvftasq lrfaw // LOCUS NP_014888 418 aa linear PLN 30-JUN-2025 DEFINITION diacylglycerol O-acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014888 VERSION NP_014888.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183664.1 REFERENCE 1 (residues 1 to 418) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 418) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 418) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 418) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 418) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11013. Method: conceptual translation. FEATURES Location/Qualifiers source 1..418 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..418 /product="diacylglycerol O-acyltransferase" /EC_number="2.3.1.20" /EC_number="2.3.1.22" /calculated_mol_wt="47580" Region 80..410 /region_name="LPLAT" /note="Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; cl17185" /db_xref="CDD:473073" Site order(195,198,221..224,269..271) /site_type="active" /note="putative acyl-acceptor binding pocket [active]" /db_xref="CDD:153249" CDS 1..418 /gene="DGA1" /locus_tag="YOR245C" /coded_by="NM_001183664.1:1..1257" /experiment="EXISTENCE:direct assay:GO:0004144 diacylglycerol O-acyltransferase activity [PMID:20225889]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:11751830|PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0006672 ceramide metabolic process [PMID:22738231]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:21321129]" /experiment="EXISTENCE:direct assay:GO:0019432 triglyceride biosynthetic process [PMID:11751830]" /experiment="EXISTENCE:mutant phenotype:GO:0004144 diacylglycerol O-acyltransferase activity [PMID:11751830]" /experiment="EXISTENCE:mutant phenotype:GO:0006672 ceramide metabolic process [PMID:22738231]" /experiment="EXISTENCE:mutant phenotype:GO:0019432 triglyceride biosynthetic process [PMID:11751830]" /experiment="EXISTENCE:mutant phenotype:GO:0019915 lipid storage [PMID:11751830]" /experiment="EXISTENCE:mutant phenotype:GO:0035356 intracellular triglyceride homeostasis [PMID:27620384]" /note="Diacylglycerol acyltransferase; catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor; Lro1p and Dga1p can O-acylate ceramides; localized to lipid particles" /db_xref="GeneID:854419" /db_xref="SGD:S000005771" ORIGIN 1 msgtfndirr rkkeegspta giterhenks lssidkreqt lkpqlesccp latpferrlq 61 tlavawhtss fvlfsiftlf aistpalwvl aipymiyfff drspatgevv nryslrfrsl 121 piwkwycdyf pisliktvnl kptftlsknk rvneknykir lwptkysinl ksnstidyrn 181 qectgptylf gyhphgigal gafgafateg cnyskifpgi pislmtlvtq fhiplyrdyl 241 lalgissvsr knalrtlskn qsicivvgga resllsstng tqlilnkrkg fiklaiqtgn 301 inlvpvfafg evdcynvlst kkdsvlgkmq lwfkenfgft ipifyarglf nydfgllpfr 361 apinvvvgrp iyvekkitnp pddvvnhfhd lyiaelkrly yenrekygvp daelkivg // LOCUS NP_014889 330 aa linear PLN 30-JUN-2025 DEFINITION Env9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014889 VERSION NP_014889.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183665.3 REFERENCE 1 (residues 1 to 330) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 330) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 330) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 330) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 330) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11014. On Jul 30, 2012 this sequence version replaced NP_014889.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..330 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..330 /product="Env9p" /calculated_mol_wt="37354" Region 17..318 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" Site order(23,25..26,28,47..49,124..126,202,206,230..231, 233..234) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:187535" CDS 1..330 /gene="ENV9" /locus_tag="YOR246C" /coded_by="NM_001183665.3:1..993" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:25546499]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:28540421|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016491 oxidoreductase activity [PMID:28540421]" /experiment="EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:21912603]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:21912603]" /experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:28540421]" /note="Conserved oxidoreductase involved in lipid droplet morphology; mutant shows defects in CPY processing and vacuolar morphology; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; homologus to human RDH12 linked to Leber Congenital Amaurosis" /db_xref="GeneID:854420" /db_xref="SGD:S000005772" ORIGIN 1 mldprilpyy dpaverkiav vtggntgigw ytvlhlylhg fvvyicgrns hkiskaiqei 61 laeakkrche dddgsspgag pgpsiqrlgs lhyihldltd lkcveraalk ilkledhidv 121 lvnnagimav plemtkdgfe vqlqtnyish fiftmrllpl lrhcrgriis lssighhlef 181 mywklsktwd ykpnmlftwf ryamsktali qctkmlaiky pdvlclsvhp glvmntnlfs 241 ywtrlpivgi ffwllfqvvg fffgvsneqg slaslkcald pnlsvekdng kyfttggkes 301 kssyvsnnvd eaastwiwtv hqlrdrgfdi // LOCUS NP_014890 210 aa linear PLN 30-JUN-2025 DEFINITION Srl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014890 VERSION NP_014890.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183666.1 REFERENCE 1 (residues 1 to 210) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 210) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 210) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 210) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 210) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11015. Method: conceptual translation. FEATURES Location/Qualifiers source 1..210 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..210 /product="Srl1p" /calculated_mol_wt="21917" CDS 1..210 /gene="SRL1" /locus_tag="YOR247W" /coded_by="NM_001183666.1:1..633" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:13679573]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006139 nucleobase-containing compound metabolic process [PMID:9744871]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:15972461]" /note="Mannoprotein that exhibits a tight association with the cell wall; required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants; SRL1 has a paralog, SVS1, that arose from the whole genome duplication" /db_xref="GeneID:854421" /db_xref="SGD:S000005773" ORIGIN 1 mlqsvvffal ltfassvsai ysnntvsttt tlapsyslvp qettisyadd tttffvtstv 61 ystswftsts atitnaasss lstssasgsv tpestheits tstitstlll tlhdsttlsp 121 sstaasvsde dsnnkdakvk sfeqastsng cvpitkfvtv tnepvtqyvt vtpntttqyv 181 tvtgapsvtt tspgnvqwyn ttsitnstsw // LOCUS NP_014892 685 aa linear PLN 30-JUN-2025 DEFINITION anaphase promoting complex subunit 5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014892 VERSION NP_014892.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183668.3 REFERENCE 1 (residues 1 to 685) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 685) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 685) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 685) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11016. On Jul 30, 2012 this sequence version replaced NP_014892.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..685 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..685 /product="anaphase promoting complex subunit 5" /calculated_mol_wt="79144" Region 296..330 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276806" Region 302..390 /region_name="ANAPC5" /note="Anaphase-promoting complex subunit 5; pfam12862" /db_xref="CDD:432838" Region 338..371 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276806" CDS 1..685 /gene="APC5" /locus_tag="YOR249C" /gene_synonym="RMC1" /coded_by="NM_001183668.3:1..2058" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005680 anaphase-promoting complex [PMID:9469814]" /experiment="EXISTENCE:direct assay:GO:0061630 ubiquitin protein ligase activity [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:12399376]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16481473]" /experiment="EXISTENCE:mutant phenotype:GO:0031145 anaphase-promoting complex-dependent catabolic process [PMID:16481473]" /note="Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress" /db_xref="GeneID:854423" /db_xref="SGD:S000005775" ORIGIN 1 mskygplgit nfitpydlci lilihahcsq dngisvptav flrlisptrp slewnpllkd 61 nsnlrsssiv pppvlpildn iirillddkd gnkialtlmg yleainglds inrlmmdlek 121 nclvnnyrsm kmrttstrrq mtrasflgtf lstcirkyqi gdfemretiw inlqnfktvf 181 khtplwlrfk dnvhiqkvkn cllandeisv edqqmveffq hfnngndads ktmneenygt 241 lisiqhlqsi vnrqivnwld ntefnlmgqe etsstyeeqs glvfdlldtl slndatkfpl 301 ifilkyleai kensyqtald slhnyfdyks tgnsqnyfhi sllslatfhs sfnecdaain 361 sfeeatriar enkdmetlnl imiwiinfie vhpeyanrfy itveqiikyl knssdvedan 421 ifsnaykfet llsmvkeskt aevsssllkf maitlqnvps qnfdlfqslv syevkfwkel 481 gyesisdvye kflsktssss lrnydssiin qdikvafkal eeddflkvkq yllkseslel 541 dydqkinlky lrvkylvkig dydlsmrlin qyvkecceev adsnwrfkfe iesinvllls 601 dvgirslpki iklideykei gnplrcvill lklcevliqv gksmeaecli scnlstilef 661 pfvrkktdel leslsveedr dvqmt // LOCUS NP_014893 445 aa linear PLN 30-JUN-2025 DEFINITION cleavage polyadenylation factor subunit CLP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014893 VERSION NP_014893.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183669.1 REFERENCE 1 (residues 1 to 445) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 445) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 445) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 445) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 445) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11017. Method: conceptual translation. FEATURES Location/Qualifiers source 1..445 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..445 /product="cleavage polyadenylation factor subunit CLP1" /calculated_mol_wt="50095" Region 23..445 /region_name="CLP1" /note="Predicted GTPase subunit of the pre-mRNA cleavage complex [Translation, ribosomal structure and biogenesis]; COG5623" /db_xref="CDD:227910" CDS 1..445 /gene="CLP1" /locus_tag="YOR250C" /coded_by="NM_001183669.1:1..1338" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:11344258]" /experiment="EXISTENCE:direct assay:GO:0031124 mRNA 3'-end processing [PMID:11344258]" /experiment="EXISTENCE:physical interaction:GO:0005849 mRNA cleavage factor complex [PMID:11344258]" /note="Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation and in gene looping which affects reinitiation of transcription; mutations in human ortholog cause cerebellar neurodegeneration" /db_xref="GeneID:854424" /db_xref="SGD:S000005776" ORIGIN 1 maslpgideh ttseelitgd newhklvipk gsdwqidlka egklivkvns giveifgtel 61 avddeytfqn wkfpiyavee tellwkcpdl ttntitvkpn htmkyiynlh fmlekirmsn 121 fegprvvivg gsqtgktsls rtlcsyalkf nayqplyinl dpqqpiftvp gcisatpisd 181 ildaqlptwg qsltsgatll hnkqpmvknf glerinenkd lylecisqlg qvvgqrlhld 241 pqvrrsgciv dtpsisqlde nlaelhhiie klnvnimlvl csetdplwek vkktfgpelg 301 nnniffipkl dgvsavddvy krslqrtsir eyfygsldta lspyaigvdy edltiwkpsn 361 vfdnevgrve lfpvtitpsn lqhaiiaitf aerradqatv ikspilgfal itevnekrrk 421 lrvllpvpgr lpskamilts yryle // LOCUS NP_014894 304 aa linear PLN 30-JUN-2025 DEFINITION thiosulfate sulfurtransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014894 VERSION NP_014894.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183670.3 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11018. On Jul 30, 2012 this sequence version replaced NP_014894.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..304 /product="thiosulfate sulfurtransferase" /EC_number="2.8.1.1" /calculated_mol_wt="34088" Region 23..290 /region_name="SseA" /note="3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]; COG2897" /db_xref="CDD:442142" CDS 1..304 /gene="TUM1" /locus_tag="YOR251C" /coded_by="NM_001183670.3:1..915" /experiment="EXISTENCE:direct assay:GO:0004792 thiosulfate-cyanide sulfurtransferase activity [PMID:19151091]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0002143 tRNA wobble position uridine thiolation [PMID:19151091|PMID:19145231]" /experiment="EXISTENCE:mutant phenotype:GO:0004792 thiosulfate-cyanide sulfurtransferase activity [PMID:19151091]" /note="Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; involved in metabolism of sterol esters; may be mitochondrially localized" /db_xref="GeneID:854425" /db_xref="SGD:S000005777" ORIGIN 1 mplfdlispk afvklvasek vhrivpvdat wylpswkldn kvdfltkpri pnsiffdida 61 isdkkspyph mfptkkvfdd amsnlgvqkd dilvvydrvg nfssprcawt lgvmghpkvy 121 llnnfnqyre fkypldsskv aafspypksh yessesfqdk eivdyeemfq lvksgelakk 181 fnafdarslg rfegtepepr sdipsghipg tqplpygsll dpetktypea geaihatlek 241 alkdfhctld pskpticscg tgvsgviikt alelagvpnv rlydgswtew vlksgpewia 301 enrd // LOCUS NP_014895 178 aa linear PLN 30-JUN-2025 DEFINITION Tma16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014895 VERSION NP_014895.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183671.1 REFERENCE 1 (residues 1 to 178) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 178) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 178) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 178) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11019. On Jan 9, 2006 this sequence version replaced NP_014895.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..178 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..178 /product="Tma16p" /calculated_mol_wt="20708" Region 23..167 /region_name="Tma16" /note="Translation machinery-associated protein 16; pfam11176" /db_xref="CDD:463236" CDS 1..178 /gene="TMA16" /locus_tag="YOR252W" /coded_by="NM_001183671.1:1..537" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /note="hypothetical protein that associates with ribosomes" /db_xref="GeneID:854426" /db_xref="SGD:S000005778" ORIGIN 1 mpvtkslskl qknlskkgkn itvhpkgrky eklvratmre dkiaakkklh qdkrvhelar 61 vkfmqdvvns dtfkgqpifd hahtrefiqs fierddteld elkkkrrsnr ppsnrqvllq 121 qrrdqelkef kagflcpdls daknmeflrn wngtfgllnt lrlirindkg eqvvggne // LOCUS NP_014896 176 aa linear PLN 30-JUN-2025 DEFINITION peptide alpha-N-acetyltransferase subunit NAT5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014896 VERSION NP_014896.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183672.3 REFERENCE 1 (residues 1 to 176) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 176) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 176) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 176) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11020. On Jul 30, 2012 this sequence version replaced NP_014896.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..176 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..176 /product="peptide alpha-N-acetyltransferase subunit NAT5" /EC_number="2.3.1.258" /calculated_mol_wt="19596" Region <93..165 /region_name="ArgA" /note="N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; COG1246" /db_xref="CDD:440859" CDS 1..176 /gene="NAT5" /locus_tag="YOR253W" /gene_synonym="ARD2; NAA50; ROG2" /coded_by="NM_001183672.3:1..531" /experiment="EXISTENCE:direct assay:GO:0031415 NatA complex [PMID:14517307]" /experiment="EXISTENCE:mutant phenotype:GO:0004596 protein-N-terminal amino-acid acetyltransferase activity [PMID:25886145]" /experiment="EXISTENCE:mutant phenotype:GO:0006474 N-terminal protein amino acid acetylation [PMID:25886145]" /note="Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing" /db_xref="GeneID:854427" /db_xref="SGD:S000005779" ORIGIN 1 mgrdictldn vyannlgmlt klahvtvpnl yqdaffsalf aedslvaknk kpsskkdvhf 61 tqmayyseip vgglvaklvp kkqnelslkg iqieflgvlp nyrhksigsk llkfaedkcs 121 echqhnvfvy lpavddltkq wfiahgfeqv getvnnfikg vngdeqdail lkkhis // LOCUS NP_014897 663 aa linear PLN 30-JUN-2025 DEFINITION protein-transporting protein SEC63 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014897 VERSION NP_014897.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183673.1 REFERENCE 1 (residues 1 to 663) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 663) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 663) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 663) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11021. Method: conceptual translation. FEATURES Location/Qualifiers source 1..663 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..663 /product="protein-transporting protein SEC63" /calculated_mol_wt="75214" Region 125..192 /region_name="DnaJ" /note="DnaJ domain; pfam00226" /db_xref="CDD:395170" Site order(153..155,170,173..174,177..178) /site_type="other" /note="HSP70 interaction site [polypeptide binding]" /db_xref="CDD:99751" Region 240..611 /region_name="SEC63" /note="Domain of unknown function in Sec63p, Brr2p and other proteins; smart00611" /db_xref="CDD:214744" CDS 1..663 /gene="SEC63" /locus_tag="YOR254C" /gene_synonym="PTL1" /coded_by="NM_001183673.1:1..1992" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:27831485|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9252322]" /experiment="EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7758110]" /experiment="EXISTENCE:mutant phenotype:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:11226176]" /experiment="EXISTENCE:mutant phenotype:GO:0006620 post-translational protein targeting to endoplasmic reticulum membrane [PMID:15671059]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:15671059]" /experiment="EXISTENCE:mutant phenotype:GO:0046967 cytosol to endoplasmic reticulum transport [PMID:15671059]" /experiment="EXISTENCE:physical interaction:GO:0031207 Sec62/Sec63 complex [PMID:2000150]" /note="Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec62p, Sec66p, and Sec72p" /db_xref="GeneID:854428" /db_xref="SGD:S000005780" ORIGIN 1 mptnyeydea setwpsfilt gllmvvgpmt llqiyqiffg anaedgnsgk skefneevfk 61 nlneeytsde ikqfrrkfdk nsnkkskiws rrniiiivgw ilvaillqri nsndaikdaa 121 tklfdpyeil gistsasdrd iksayrklsv kfhpdklakg ltpdeksvme etyvqitkay 181 esltdelvrq nylkyghpdg pqstshgial prflvdgsas pllvvcyval lglilpyfvs 241 rwwartqsyt kkgihnvtas nfvsnlvnyk pseivttdli lhwlsfahef kqffpdlqpt 301 dfekllqdhi nrrdsgklnn akfrivakch sllhglldia cgfrnldial gaintfkciv 361 qavpltpncq ilqlpnvdke hfitktgdih tlgklftled akigevlgik dqaklnetlr 421 vashipnlki ikadflvpge nqvtpsstpy islkvlvrsa kqpliptsli peenltepqd 481 fesqrdpfam mskqplvpys fapffptkrr gswcclvssq kdgkilqtpi iieklsyknl 541 nddkdffdkr ikmdltkhek fdindweigt ikiplgqpap etvgdfffrv ivkstdyftt 601 dlditmnmkv rdspaveqve vyseeddeys tdddetesdd esdasdytdi dtdteaedde 661 spe // LOCUS NP_014898 278 aa linear PLN 30-JUN-2025 DEFINITION Osw1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014898 VERSION NP_014898.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183674.3 REFERENCE 1 (residues 1 to 278) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 278) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 278) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 278) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 278) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11022. On Jul 30, 2012 this sequence version replaced NP_014898.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..278 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..278 /product="Osw1p" /calculated_mol_wt="32627" CDS 1..278 /gene="OSW1" /locus_tag="YOR255W" /coded_by="NM_001183674.3:1..837" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:15590821]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:17110477]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]" /note="Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p" /db_xref="GeneID:854429" /db_xref="SGD:S000005781" ORIGIN 1 mrappsprks ksghffylyf rlcqlfsgrk lkrrwhvhkl hihqyntrwn lsplseihie 61 dminepsglc pgsskkkpll iarfpkgcqe sprvyvlqrn nlsrlklskr kyalrfyhne 121 ifgnnlkrkd gsihkvehqq caetvrkikk vtanhadvki ifhdkntirs dklggrsnkm 181 qtrpsvleed veeevssvyi rfcddhslrv kdyhslhrhs kksskekrnn qeigkskllg 241 klfeeetsrq nkgvekkldt iviqkfqnyp ivsfsrvi // LOCUS NP_014899 809 aa linear PLN 30-JUN-2025 DEFINITION putative zinc metalloprotease [Saccharomyces cerevisiae S288C]. ACCESSION NP_014899 VERSION NP_014899.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183675.2 REFERENCE 1 (residues 1 to 809) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 809) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 809) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 809) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 809) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11023. Method: conceptual translation. FEATURES Location/Qualifiers source 1..809 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..809 /product="putative zinc metalloprotease" /calculated_mol_wt="91865" Region 249..392 /region_name="PA" /note="Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At...; cd00538" /db_xref="CDD:238300" Site 329..331 /site_type="other" /note="PA/protease or protease-like domain interface [polypeptide binding]" /db_xref="CDD:238300" Region 417..643 /region_name="M28_PMSA_TfR_like" /note="M28 Zn-peptidase Transferrin Receptor-like family; cd03874" /db_xref="CDD:349871" Site order(436..437,439,484,486,505..506,508,510..513,640) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:349871" Region 668..799 /region_name="TFR_dimer" /note="Transferrin receptor-like dimerization domain; pfam04253" /db_xref="CDD:461238" CDS 1..809 /gene="TRE2" /locus_tag="YOR256C" /coded_by="NM_001183675.2:1..2430" /experiment="EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:19369420]" /note="Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitination and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication" /db_xref="GeneID:854430" /db_xref="SGD:S000005782" ORIGIN 1 mrssyqpvst tnfehenaip tassshnllm sqrfddspps sndnsietni tpppeppsye 61 fdiedphddl hkrthlqrvs igfqekilep lmeniihpll qiskfvpdka dyylskignp 121 filrrffyii fmsfiayyvl ssgylfneka sgskgmfsqh dilfeyakks vdlakferdl 181 eyissmphgs gtkgdaaiyr yiqesfdnng lklvkemgys vysnypgnvs isyydnknek 241 hdlelskenf nplssngkls kvsliyggkg ttydlqhlkd sktiedgkdy vlllqydklv 301 sqqvliaekf gakavifise pygenidvvq skpvglpqys tgdasglnwd gspveekdhk 361 fwrqthipti pistrqgkel lsrlssggvt vddgnsdrsn sgkmgdvlid vdlqtnvrek 421 hfipnivgki egreqsdkai iiaasrnsin fgttypnfgt aallsivqlf qevkykfgwk 481 plrniyfisf ggtefnyags selveqrltp lkdeiyslid isqlgipfae kyengktrge 541 lsiethpllk kffnrnahgn fdisvdnvqh ygdwtpflan gipvsvissd strnrdtpte 601 tsedkferve kiledeqnqq svkdllvyll hismeliddp llhfdiisyv ediderlqrl 661 eqaypeklnf tsiikgllfw kkigsewasw tqgwenivws hgdgiepsll sinrwtwnkk 721 ltnigrrtcs paglpnrsfy knvlfgptli qedksknggn vdfwtfpgvm daiydddwkr 781 aqeqidligk vlhqsaalfv eetndigyk // LOCUS NP_014900 161 aa linear PLN 30-JUN-2025 DEFINITION centrin [Saccharomyces cerevisiae S288C]. ACCESSION NP_014900 VERSION NP_014900.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183676.3 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11024. On Jul 30, 2012 this sequence version replaced NP_014900.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..161 /product="centrin" /calculated_mol_wt="18620" Region 14..159 /region_name="PTZ00183" /note="centrin; Provisional" /db_xref="CDD:185503" CDS 1..161 /gene="CDC31" /locus_tag="YOR257W" /gene_synonym="DSK1" /coded_by="NM_001183676.3:1..486" /experiment="EXISTENCE:direct assay:GO:0005825 half bridge of spindle pole body [PMID:8408222]" /experiment="EXISTENCE:direct assay:GO:0070390 transcription export complex 2 [PMID:15311284]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:9153752]" /experiment="EXISTENCE:mutant phenotype:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:18160718]" /note="Calcium-binding component of the spindle pole body (SPB) half-bridge; required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation" /db_xref="GeneID:854431" /db_xref="SGD:S000005783" ORIGIN 1 msknrsslqs gplnsellee qkqeiyeafs lfdmnndgfl dyhelkvamk algfelpkre 61 ildlideyds egrhlmkydd fyivmgekil krdpldeikr afqlfdddht gkisiknlrr 121 vakelgetlt deelramiee fdldgdgein enefiaictd s // LOCUS NP_014901 217 aa linear PLN 30-JUN-2025 DEFINITION DNA 5'-adenosine monophosphate hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014901 VERSION NP_014901.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183677.1 REFERENCE 1 (residues 1 to 217) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 217) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 217) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 217) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11025. Method: conceptual translation. FEATURES Location/Qualifiers source 1..217 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..217 /product="DNA 5'-adenosine monophosphate hydrolase" /EC_number="3.6.1.71" /EC_number="3.6.1.72" /calculated_mol_wt="25626" Region 15..139 /region_name="HIT" /note="HIT domain; pfam01230" /db_xref="CDD:395984" Region 153..212 /region_name="zf-C2HE" /note="C2HE / C2H2 / C2HC zinc-binding finger; pfam16278" /db_xref="CDD:465082" CDS 1..217 /gene="HNT3" /locus_tag="YOR258W" /coded_by="NM_001183677.1:1..654" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0033699 DNA 5'-adenosine monophosphate hydrolase activity [PMID:16964241]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:20399152]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:20399152]" /note="DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia; relative distribution to nuclear foci decreases upon DNA replication stress" /db_xref="GeneID:854432" /db_xref="SGD:S000005784" ORIGIN 1 mswryalkny vtspetvndd tvtyfddkvs iirdsfpkse chllilprtm qlsrshptkv 61 idakfknefe syvnsaidhi frhfqekfri kksdddkdpc wddilkdknk fvrnfvqvgi 121 hsvpsmanlh ihviskdfhs vrlknkkhyn sfntgffisw ddlplngknl gtdkeietty 181 lkehdllccy cqrnfsnkfs llkkhlelef nshfelk // LOCUS NP_014902 437 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle base subunit RPT4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014902 VERSION NP_014902.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183678.3 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11026. On Jul 30, 2012 this sequence version replaced NP_014902.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..437 /product="proteasome regulatory particle base subunit RPT4" /calculated_mol_wt="49277" Region 66..433 /region_name="PRK03992" /note="proteasome-activating nucleotidase; Provisional" /db_xref="CDD:179699" CDS 1..437 /gene="RPT4" /locus_tag="YOR259C" /gene_synonym="CRL13; PCS1; SUG2" /coded_by="NM_001183678.3:1..1314" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10419517]" /experiment="EXISTENCE:direct assay:GO:0008540 proteasome regulatory particle, base subcomplex [PMID:9741626|PMID:11742986]" /experiment="EXISTENCE:direct assay:GO:0019904 protein domain specific binding [PMID:11418596]" /experiment="EXISTENCE:genetic interaction:GO:0006289 nucleotide-excision repair [PMID:11410533]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:11389845]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:18174173]" /experiment="EXISTENCE:mutant phenotype:GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:19843524]" /experiment="EXISTENCE:mutant phenotype:GO:0070682 proteasome regulatory particle assembly [PMID:19412160]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:12447385]" /note="ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization" /db_xref="GeneID:854433" /db_xref="SGD:S000005785" ORIGIN 1 mseeqdplla glgetsgdnh tqqsheqqpe qpqeteehhe eepsrvdpeq eahnkalnqf 61 krkllehrry ddqlkqrrqn irdleklydk tendikalqs igqligevmk elseekyivk 121 assgpryivg vrnsvdrskl kkgvrvtldi ttltimrilp retdplvynm tsfeqgeitf 181 dgigglteqi relrevielp lknpeifqrv gikppkgvll ygppgtgktl lakavaatig 241 anfifspasg ivdkyigesa riiremfaya kehepciifm devdaiggrr fsegtsadre 301 iqrtlmellt qmdgfdnlgq tkiimatnrp dtldpallrp grldrkveip lpneagrlei 361 fkihtakvkk tgefdfeaav kmsdgfngad irncateagf fairddrdhi npddlmkavr 421 kvaevkkleg tieyqkl // LOCUS NP_014903 578 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF2B subunit gamma [Saccharomyces cerevisiae S288C]. ACCESSION NP_014903 VERSION NP_014903.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183679.1 REFERENCE 1 (residues 1 to 578) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 578) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 578) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 578) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 578) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11027. Method: conceptual translation. FEATURES Location/Qualifiers source 1..578 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..578 /product="translation initiation factor eIF2B subunit gamma" /calculated_mol_wt="65569" Region 3..285 /region_name="eIF-2B_gamma_N" /note="The N-terminal domain of gamma subunit of the eIF-2B is a subfamily of glycosyltransferase 2; cd04198" /db_xref="CDD:133041" Region 433..513 /region_name="LbH_eIF2B_gamma_C" /note="eIF-2B gamma subunit, C-terminal Left-handed parallel beta-Helix (LbH) domain: eIF-2B is a eukaryotic translation initiator, a guanine nucleotide exchange factor (GEF) composed of five different subunits (alpha, beta, gamma, delta and epsilon). eIF2B is...; cd04652" /db_xref="CDD:100057" CDS 1..578 /gene="GCD1" /locus_tag="YOR260W" /gene_synonym="TRA3" /coded_by="NM_001183679.1:1..1737" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9472020|PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005851 eukaryotic translation initiation factor 2B complex [PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:8506384]" /experiment="EXISTENCE:direct assay:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:9472020|PMID:8506384]" /experiment="EXISTENCE:genetic interaction:GO:0006446 regulation of translational initiation [PMID:3516411]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:2038327|PMID:11707417]" /experiment="EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:1986242|PMID:3915540|PMID:2038327|PMID:3516411]" /experiment="EXISTENCE:mutant phenotype:GO:1903574 negative regulation of cellular response to amino acid starvation [PMID:6351059]" /experiment="EXISTENCE:physical interaction:GO:0003743 translation initiation factor activity [PMID:2038327]" /experiment="EXISTENCE:physical interaction:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9472020]" /experiment="EXISTENCE:physical interaction:GO:0032045 guanyl-nucleotide exchange factor complex [PMID:9472020]" /note="Gamma subunit of the translation initiation factor eIF2B; the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression" /db_xref="GeneID:854434" /db_xref="SGD:S000005786" ORIGIN 1 msiqafvfcg kgsnlapftq pdfpfqtqnk dstaatsgdk lnelvnsald stvinefmqh 61 strlpkallp ignrpmieyv ldwcdqadfk eisvvapvde ieliesglts flslrkqqfe 121 liykalsnsn hshhlqdpkk infipskans tgeslqkell pringdfvil pcdfvtdipp 181 qvlvdqfrnr ddnnlamtiy yknsldssid kkqqqkqkqq qfftvysene dserqpilld 241 vysqrdvtkt kylqirshll wnypnltvst kllnsfiyfc sfelcqllkl gpqsmsrqas 301 fkdpftgnqq qqnppttddd edrnhddddd ykpsatsiqp tyfkkkndli ldpincnksl 361 skvfrdlsrr swqhskprep igifilpnet lfirannlna ymdanrfvlk iksqtmftkn 421 iqiqsaaiga daivdpkcqi sahsnvkmsv lgtqanigsr crvagsllfp gvhlgdevil 481 enciigpmak igskcklsnc yieghyvvep knnfkgetla nvyldedeed eliyddsvia 541 geseiaeetd sddrsdedsd dseytdeyey eddglfer // LOCUS NP_014904 338 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle lid subunit RPN8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014904 VERSION NP_014904.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183680.3 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11028. On Jul 30, 2012 this sequence version replaced NP_014904.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..338 /product="proteasome regulatory particle lid subunit RPN8" /calculated_mol_wt="38182" Region 6..303 /region_name="MPN_RPN7_8" /note="Mpr1p, Pad1p N-terminal (MPN) domains without catalytic isopeptidase activity, found in 19S proteasomal subunits Rpn7 and Rpn8; cd08062" /db_xref="CDD:163693" CDS 1..338 /gene="RPN8" /locus_tag="YOR261C" /coded_by="NM_001183680.3:1..1017" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:11742986|PMID:9741626]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27053109]" /note="Essential non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p" /db_xref="GeneID:854435" /db_xref="SGD:S000005787" ORIGIN 1 mslqhekvti aplvllsald hyertqtken krcvgvilgd ansstirvtn sfalpfeede 61 knsdvwfldh nyienmnemc kkinakekli gwyhsgpklr asdlkinelf kkytqnnpll 121 livdvkqqgv glptdayvai eqvkddgtst ektflhlpct ieaeeaeeig vehllrdvrd 181 qaagglsirl tnqlkslkgl qsklkdvvey ldkvinkelp inhtilgklq dvfnllpnlg 241 tpdddeidve nhdrinisnn lqkaltvktn delmviyisn lvrsiiafdd lienkiqnkk 301 iqeqrvkdkq skvsddsese sgdkeatapl iqrknkkn // LOCUS NP_014905 347 aa linear PLN 30-JUN-2025 DEFINITION GTPase GPN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014905 VERSION NP_014905.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183681.1 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11029. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..347 /product="GTPase GPN2" /calculated_mol_wt="39593" Region 3..257 /region_name="GPN2" /note="GPN-loop GTPase 2; cd17871" /db_xref="CDD:349780" Site order(10..17,175..176,178,234,241..243) /site_type="active" /note="putative active site [active]" /db_xref="CDD:349780" CDS 1..347 /gene="GPN2" /locus_tag="YOR262W" /coded_by="NM_001183681.1:1..1044" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:14690591]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:23267056]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:18439903]" /note="Putative GTPase with a specific role in RNA pol II and polIII biogenesis; involved in the assembly and subsequent nuclear import of RNA polymerases II and III; required for establishment of sister chromatid cohesion; contains a Gly-Pro-Asn motif in the G domain; similar to Npa3p and Gpn3p; highly conserved across species and homologous to human gene GPN2/ATPBD1B" /db_xref="GeneID:854436" /db_xref="SGD:S000005788" ORIGIN 1 mpfaqivigp pgsgkstycn gcsqffnaig rhsqvvnmdp andalpypca vdirdfitle 61 eimqeqqlgp ngglmyaves ldnsidlfil qikslveeek aylvfdcpgq velfthhssl 121 fnifkkmeke ldirfcvvnl idcfymtsps qyisilllal rsmlmmdlph invfskidml 181 ksygelpfrl dyytevqdld ylepyiekeg ssvlgkkysk ltetikelvs dfnlvsfevl 241 svddkesmin lqgvidkang yifgasevgg dtvwaeasre galianydiq drwidnkeky 301 dkeeeekrta llkeqelqnk avdvneedew enalkeweek qgmdfvr // LOCUS NP_014907 430 aa linear PLN 30-JUN-2025 DEFINITION Dse3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014907 VERSION NP_014907.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183683.3 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11030. On Jul 30, 2012 this sequence version replaced NP_014907.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..430 /product="Dse3p" /calculated_mol_wt="47968" CDS 1..430 /gene="DSE3" /locus_tag="YOR264W" /coded_by="NM_001183683.3:1..1293" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:14562095]" /note="Daughter cell-specific protein, may help establish daughter fate; relocalizes from bud neck to cytoplasm upon DNA replication stress; interacts with Csm1p" /db_xref="GeneID:854437" /db_xref="SGD:S000005790" ORIGIN 1 mprkflgnki eknvdavrps sltltaddlk yippipqdfe deddkvlrts nggnrlskrf 61 ggtlklkkrl esvpelflhd fkkrprsqle virekkftdm qvpkgpvcpq stilplrerk 121 kvkslpiqrk slrrptlskp avvqslghkt hsdhiidkvf vsrpapivmp vkaltpinpv 181 slmqtqtqdc crknkygksg seilfdeils ayenvstsds talnseidri idicaskqia 241 kkneafqvpy vvcpddtetl fssttpklkp vnsntlndvi sspeyttsgc stysdqsnsd 301 eelsevesiv wntnkrtmrs sivsestsee gyctaaetlp stvsvedldi hnklpkvaqt 361 sscntllnkl sirklkkvil dppkimhvmt fdddsddgdd nddedralni lqkkidciei 421 ascsssiyse // LOCUS NP_014908 106 aa linear PLN 30-JUN-2025 DEFINITION Rbl2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014908 VERSION NP_014908.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183684.1 REFERENCE 1 (residues 1 to 106) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 106) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 106) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 106) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 106) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11031. Method: conceptual translation. FEATURES Location/Qualifiers source 1..106 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..106 /product="Rbl2p" /calculated_mol_wt="12248" Region 1..96 /region_name="TBCA" /note="Tubulin binding cofactor A; pfam02970" /db_xref="CDD:460769" CDS 1..106 /gene="RBL2" /locus_tag="YOR265W" /coded_by="NM_001183684.1:1..321" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:11739729]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:11739729|PMID:10978276]" /experiment="EXISTENCE:mutant phenotype:GO:0048487 beta-tubulin binding [PMID:11739729]" /note="Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854439" /db_xref="SGD:S000005791" ORIGIN 1 maptqldikv kalkrltkee gyyqqelkdq eahvaklked ksvdpydlkk qeevlddtkr 61 llptlyekir efkedleqfl ktyqgtedvs darsaitsaq elldsk // LOCUS NP_014909 423 aa linear PLN 30-JUN-2025 DEFINITION Pnt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014909 VERSION NP_014909.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183685.3 REFERENCE 1 (residues 1 to 423) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 423) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 423) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 423) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 423) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11032. On Jul 30, 2012 this sequence version replaced NP_014909.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..423 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..423 /product="Pnt1p" /calculated_mol_wt="48803" CDS 1..423 /gene="PNT1" /locus_tag="YOR266W" /coded_by="NM_001183685.3:1..1272" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10490599]" /experiment="EXISTENCE:genetic interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11950926]" /experiment="EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:10490599]" /experiment="EXISTENCE:physical interaction:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:11950926]" /note="Mitochondrial integral inner membrane protein; involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine" /db_xref="GeneID:854440" /db_xref="SGD:S000005792" ORIGIN 1 mdsrvalvrk yiapsviksd siqlhglvka plfkalnsry klgslqivqd vdwnakttps 61 dspeplaatl nsnrslpmtk fpkqeileqv kldtkvgkwr kfmtgwfrig lyllksyktg 121 iqntlkvfwd trneeqkfsi kngalanlvr eiemheintr lsssslptss sakaplrpls 181 inrktlveli rrdqiwklpv fftlvfifee vsvliftffp rvcpyncltp ggykklsnsy 241 ikgttstqgn yglgpleftk qgtikyeppy avpienlynf ltsfpqsmis nwklyiykkl 301 klqkllcnei ekiyqylfid dwlllqsiln tdvektkial sdrelvncil erklyhmgdd 361 lnemvndtlg keillkrlfl ywtlryndti slngkhtfse kwgvnnisll kynselvatk 421 diq // LOCUS NP_014910 759 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase HRK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014910 VERSION NP_014910.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183686.1 REFERENCE 1 (residues 1 to 759) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 759) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 759) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 759) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11033. Method: conceptual translation. FEATURES Location/Qualifiers source 1..759 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..759 /product="putative serine/threonine protein kinase HRK1" /EC_number="2.7.11.1" /calculated_mol_wt="85565" Region 221..435 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(221..224,227,229,242,244,278,296..299,340,344..345, 347,357..358) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" Region <469..620 /region_name="MSCRAMM_ClfA" /note="MSCRAMM family adhesin clumping factor ClfA; NF033609" /db_xref="CDD:468110" Region <677..721 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" CDS 1..759 /gene="HRK1" /locus_tag="YOR267C" /coded_by="NM_001183686.1:1..2280" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006873 intracellular monoatomic ion homeostasis [PMID:11003661]" /note="Protein kinase; implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism and under acetic acid stress; plays a role in ion homeostasis; maintains pH homeostasis and modulates plasma membrane potential under acetic acid stress; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854441" /db_xref="SGD:S000005793" ORIGIN 1 mpnllsrnpf hghhndhhhd renssnnppq lirssksfln figrkqsnds lrsekstdsm 61 kstttttnyt ttnlnnnths hsnatsistn nynnnyetnh hhnishglhd ytspaspkqt 121 hsmaelkrff rpsvnkklsm sqlrskkhst hspppsksts tvnlnnhyra qhphgftdhy 181 ahtqsaipps tdsilslsnn iniyhddcil aqkygklgkl lgsgaggsvk vlvrptdgat 241 favkefrprk pnesvkeyak kctaefcigs tlhhpnviet vdvfsdskqn kyyevmeycp 301 idffavvmtg kmsrgeincc lkqltegvky lhsmglahrd lkldncvmts qgilklidfg 361 savvfrypfe dgvtmahgiv gsdpylapev itstksydpq cvdiwsigii yccmvlkrfp 421 wkaprdsddn frlycmpddi ehdyvesarh heellkerke krqrflnhsd csainqqqpa 481 hesnlktvqn qvpntpasiq gksdnkpdiv eeeteenked dsnndkestp dndkestidi 541 kisknenkst vvsanpkkvd adadadcdan gdsngrvdck ansdcndktd cnanndcsne 601 sdcnakvdtn vntaananpd mvpqnnpqqq qqqqqqqqqq qqqqqqqhhh hqhqnqdkah 661 siasdnkssq qhrgphhkki ihgpyrllrl lphasrpims rilqvdpkkr atlddifnde 721 wfaaiaactm dsknkvirap ghhhtlvree nahletykv // LOCUS NP_014911 132 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR268C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014911 VERSION NP_014911.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183687.3 REFERENCE 1 (residues 1 to 132) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 132) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 132) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 132) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 132) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11034. On Jul 30, 2012 this sequence version replaced NP_014911.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..132 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..132 /product="uncharacterized protein" /calculated_mol_wt="15064" CDS 1..132 /locus_tag="YOR268C" /coded_by="NM_001183687.3:1..399" /note="hypothetical protein; sporulation is abnormal in homozygous diploid; SWAT-GFP fusion protein localizes to the nucleus; YOR268C is not an essential gene" /db_xref="GeneID:854442" /db_xref="SGD:S000005794" ORIGIN 1 mvfvfpfpff sygfssflea gkkasykmyy aepelkttrt gravacdags priirvtlkd 61 kiglserftg rvfcylavac awlsqyyhht caffilyvhv cvcflffrwc lfatvslihe 121 sqtqagsayy tk // LOCUS NP_014912 494 aa linear PLN 30-JUN-2025 DEFINITION Pac1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014912 VERSION NP_014912.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183688.1 REFERENCE 1 (residues 1 to 494) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 494) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 494) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 494) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11035. Method: conceptual translation. FEATURES Location/Qualifiers source 1..494 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..494 /product="Pac1p" /calculated_mol_wt="56770" Region 155..492 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Region 158..196 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Site order(172,176,182..183,196..197,224,228,234..235,251..252, 271,276,282..283,296,311,316,324..325,335..336,375,379, 385..386,415..416,431,436,442..443,455,457,482,486,492) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 202..251 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 256..294 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 301..339 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 346..414 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 420..458 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 465..492 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..494 /gene="PAC1" /locus_tag="YOR269W" /gene_synonym="LIS1" /coded_by="NM_001183688.1:1..1485" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15965467]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:12566428|PMID:15965467]" /experiment="EXISTENCE:direct assay:GO:0051010 microtubule plus-end binding [PMID:15965467]" /experiment="EXISTENCE:direct assay:GO:1903033 positive regulation of microtubule plus-end binding [PMID:25380312]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:12566428]" /note="Regulator of dynein, involved in intracellular transport; part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly" /db_xref="GeneID:854443" /db_xref="SGD:S000005795" ORIGIN 1 mtnwqqqlpl tdtqkneldk svlrylnwny kqtvrhehaq dyesvrhaiv tlsgfllqes 61 vdrqefisnn dtsnesmvdi delllpkkwn sivrlqkkii eleqntetlv sqikdlntqv 121 selaqfkptt sngtsahnvl kwiprnlpsc linvessvts vklhpnlpiv fvatdhgkly 181 afdlfnytip laslqshtka itsmdvlftn ytnsskknyl vivtaskdlq ihvfkwvsee 241 ckfqqirsll ghehivsavk iwqknndvhi ascsrdqtvk iwdfhngwsl ktfqphsqwv 301 rsidvlgdyi isgshdttlr lthwpsgngl svgtghefpi ekvkfihfie dspeirfrtp 361 stdryknwgm qycvsasrdr tikiweiplp tlmahrapip nptdsnfrcv ltlkghlswv 421 rdisirgqyl fscaddksvr cwdlntgqcl hvweklhtgf vncldldvdf dsnvtprqmm 481 vtggldcksn vfmr // LOCUS NP_014913 840 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V0 sector ATPase subunit a [Saccharomyces cerevisiae S288C]. ACCESSION NP_014913 VERSION NP_014913.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183689.3 REFERENCE 1 (residues 1 to 840) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 840) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 840) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 840) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 840) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11036. On Jul 30, 2012 this sequence version replaced NP_014913.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..840 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..840 /product="H(+)-transporting V0 sector ATPase subunit a" /calculated_mol_wt="95398" Region 31..822 /region_name="V_ATPase_I" /note="V-type ATPase 116kDa subunit family; pfam01496" /db_xref="CDD:460232" CDS 1..840 /gene="VPH1" /locus_tag="YOR270C" /coded_by="NM_001183689.3:1..2523" /experiment="EXISTENCE:direct assay:GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain [PMID:1385813]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11853670]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:22842922|PMID:27881666|PMID:18048916]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:direct assay:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:8798414|PMID:1385813]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:31023825]" /experiment="EXISTENCE:genetic interaction:GO:0071474 cellular hyperosmotic response [PMID:31023825]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:9933515]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:1385813]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:1385813|PMID:8798414]" /experiment="EXISTENCE:mutant phenotype:GO:1903778 protein localization to vacuolar membrane [PMID:34342352]" /note="Subunit a of the vacuolar-ATPase V0 domain; encodes one of two isoforms, located in vacuolar V-ATPase complexes while STV1 encodes the second isoform and is located in Golgi and endosomal V-ATPase complexes; interaction with PI(3,5)P2 increases V-ATPase activity and contributes to hyperosmotic stress tolerance; relative distribution to the vacuolar membrane decreases upon DNA replication stress; human homolog ATP6V0A4 implicated in renal tubular acidosis, can complement yeast null mutant" /db_xref="GeneID:854444" /db_xref="SGD:S000005796" ORIGIN 1 maekeeaifr saemalvqfy ipqeisrdsa ytlgqlglvq frdlnskvra fqrtfvneir 61 rldnverqyr yfysllkkhd iklyegdtdk yldgsgelyv ppsgsviddy vrnasyleer 121 liqmedatdq ievqkndleq yrfilqsgde fflkgdntds tsymdedmid angeniaaai 181 gasvnyvtgv iardkvatle qilwrvlrgn lffktveieq pvydvktrey khknafivfs 241 hgdliikrir kiaesldanl ydvdssnegr sqqlakvnkn lsdlytvlkt tsttlesely 301 aiakeldswf qdvtrekaif eilnksnydt nrkiliaegw iprdelatlq arlgemiarl 361 gidvpsiiqv ldtnhtpptf hrtnkftagf qsicdcygia qyreinaglp tivtfpfmfa 421 imfgdmghgf lmtlaalslv lnekkinkmk rgeifdmaft gryiillmgv fsmytgflyn 481 difsktmtif ksgwkwpdhw kkgesitats vgtypigldw awhgtenall fsnsykmkls 541 ilmgfihmty syffslanhl yfnsmidiig nfipgllfmq gifgylsvci vykwavdwvk 601 dgkpapglln mlinmflspg tiddelyphq akvqvflllm alvcipwlll vkplhfkfth 661 kkksheplps teadassedl eaqqlisamd addaeeeevg sgshgedfgd imihqvihti 721 efclncvsht asylrlwals lahaqlssvl wtmtiqiafg frgfvgvfmt valfamwfal 781 tcavlvlmeg tsamlhslrl hwvesmskff vgeglpyepf afeykdmeva vasasssass // LOCUS NP_014914 327 aa linear PLN 30-JUN-2025 DEFINITION Fsf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014914 VERSION NP_014914.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183690.1 REFERENCE 1 (residues 1 to 327) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 327) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 327) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 327) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 327) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11037. Method: conceptual translation. FEATURES Location/Qualifiers source 1..327 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..327 /product="Fsf1p" /calculated_mol_wt="35283" Region 10..327 /region_name="SFXNs" /note="Sideroflexins; pfam03820" /db_xref="CDD:461063" CDS 1..327 /gene="FSF1" /locus_tag="YOR271C" /coded_by="NM_001183690.1:1..984" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0071454 cellular response to anoxia [PMID:23467670]" /note="Putative protein; predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis" /db_xref="GeneID:854445" /db_xref="SGD:S000005797" ORIGIN 1 massvpgpid lpesrydlst ywgrirhcae isdptmlltt ekdlaharei isayrhgelk 61 ettpefwrak kqldstvhpd tgktvllpfr mssnvlsnlv vtvgmltpgl gtagtvfwqw 121 anqslnvavn sanankshpm stsqlltnya aavtascgva lglnnlvprl knisphskli 181 lgrlvpfaav vsagivnvfl mrgneirkgi svfdsngdev gkskkaafma vgetalsrvi 241 natptmvipp lilvrlqrgv lkgkslgvqt lanlglisvt mfsalpfalg ifpqrqaihl 301 nklepelhgk kdkdgkpiek vyfnrgi // LOCUS NP_014915 460 aa linear PLN 30-JUN-2025 DEFINITION Ytm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014915 VERSION NP_014915.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183691.3 REFERENCE 1 (residues 1 to 460) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 460) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 460) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 460) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11038. On Jul 30, 2012 this sequence version replaced NP_014915.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..460 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..460 /product="Ytm1p" /calculated_mol_wt="51228" Region 8..72 /region_name="NLE" /note="NLE (NUC135) domain; pfam08154" /db_xref="CDD:462380" Region 103..451 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Region 106..142 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Site order(120,124,130..131,142..143,160,164,170,194,206..207, 228,234,249,286,304,309,315..316,328..329,346,350,356..357, 373..374,392,397,403..404,424..425,442,446) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 148..206 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 242..284 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 290..326 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 332..372 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 378..403 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..460 /gene="YTM1" /locus_tag="YOR272W" /gene_synonym="CST14" /coded_by="NM_001183691.3:1..1383" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11583614]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:17443350]" /experiment="EXISTENCE:direct assay:GO:0070545 PeBoW complex [PMID:16287855]" /experiment="EXISTENCE:direct assay:GO:0110136 protein-RNA complex remodeling [PMID:20542003]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11583614]" /experiment="EXISTENCE:mutant phenotype:GO:0051276 chromosome organization [PMID:10454593]" /experiment="EXISTENCE:physical interaction:GO:0070545 PeBoW complex [PMID:16287855]" /note="Ribosomal assembly factor and 66S pre-ribosomal particle constituent; subunit of the Nop7-subcomplex (PeBoW complex), required for an early nucleolar step in pre-60S ribosomal particle maturation; interaction of its ubiquitin-like (UBL) domain with the MIDAS domain in the Rea1p tail triggers release of the subcomplex and possibly other biogenesis factors via cycles of ATP hydrolysis; involved in the processing of 27S pre-rRNA; contains an N-terminal UBL domain and seven C-terminal WD repeats" /db_xref="GeneID:854446" /db_xref="SGD:S000005798" ORIGIN 1 mtedksqvki rfftrekdel lhvqdtpmya pislkrygls eivnhllgse kpvpfdflie 61 gellrtslhd yltkkglsse aslnveytra ilppsylnsf snedwvssld vgdgskhiis 121 gsydgivrtw dlsgnvqkqy sghsgpirav kyisntrlvs agndrtlrlw ktknddlklt 181 sqqqaqeddd devniedgkt laileghkap vvsidvsdns rilsasydns igfwstiyke 241 mtvvdpledi nnpnnkista arkrrkltmk dgtirrrapl slleshtapv eqvifdstdn 301 tvgysvsqdh tiktwdlvta rcidtrttsy sllsiaqlst lnllacgssa rhitlhdprv 361 gasskvtqqq lighknfvss ldtcpeneyi lcsgshdgtv kvwdvrstsp mytitredks 421 vqkgvndkvf avkwaekvgi isagqdkkiq inkgdnifkn // LOCUS NP_014916 659 aa linear PLN 30-JUN-2025 DEFINITION Tpo4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014916 VERSION NP_014916.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183692.1 REFERENCE 1 (residues 1 to 659) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 659) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 659) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 659) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 659) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11039. Method: conceptual translation. FEATURES Location/Qualifiers source 1..659 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..659 /product="Tpo4p" /calculated_mol_wt="73092" Region 95..546 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(105..106,109..110,113,143,194..195,197..199,202,222, 225..226,229,326,329..330,333..335,338,362,366,465..466, 470,474,490,493..494,497..498,501) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..659 /gene="TPO4" /locus_tag="YOR273C" /coded_by="NM_001183692.1:1..1980" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12562762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000296 spermine transport [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0000297 spermine transmembrane transporter activity [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0015606 spermidine transmembrane transporter activity [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0015848 spermidine transport [PMID:11171066]" /note="Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane" /db_xref="GeneID:854447" /db_xref="SGD:S000005799" ORIGIN 1 mpssltktes nsdprtniqq vpkaldknvt nsgnldstss stgsitedek rsepnadsnn 61 mtggepidpr dldwdgpddp dnphnwsslk kwyttmtsaf lclvvtmgss lyvssvpelv 121 eryhvsqtla lagltfyllg lstvigapls evfgrkpvyl fslpvsmlft mgvglsnghm 181 riilplrfls gvfaspalsv gsgtildifd vdqvsvamty fvlspflgpv lspimagfat 241 eakgwrwsew iqliagglil pfialmpeth kgiilrkrak krnialkkfs reaqkeflkt 301 tvtitilrpl kmlvvepivf vfsvyvafif ailfgffeay aviyrgvyhm smgisglpfi 361 gigvglwiga ffylyidrky lfpkppagtq pltekertsk rttpyrgard aetgellpvv 421 pekfliackf gsvalpiglf wqawtarsdv hwmapvaagv pfgfglilif fsvlmyfstc 481 yppltvascl aannllryvm ssvfplftiq mytkmkikwa stlfalvcvv mipipwvfek 541 wgsklrhksq fgyaamekea eteggiddvn avdgelnltr mttlrtmetd pstrekpger 601 lslrrthtqp vpasfdredg qhaqnrnepi snslysaikd nedgysytem atdasarmv // LOCUS NP_014917 428 aa linear PLN 30-JUN-2025 DEFINITION tRNA dimethylallyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014917 VERSION NP_014917.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183693.3 REFERENCE 1 (residues 1 to 428) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 428) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 428) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 428) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 428) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11040. On Jul 30, 2012 this sequence version replaced NP_014917.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..428 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..428 /product="tRNA dimethylallyltransferase" /EC_number="2.5.1.75" /calculated_mol_wt="50106" Region 16..320 /region_name="miaA" /note="tRNA dimethylallyltransferase; TIGR00174" /db_xref="CDD:213512" CDS 1..428 /gene="MOD5" /locus_tag="YOR274W" /coded_by="NM_001183693.3:1..1287" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:23898186]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9872948]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9872948]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:9872948|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9872948]" /experiment="EXISTENCE:direct assay:GO:0006400 tRNA modification [PMID:18852462]" /experiment="EXISTENCE:direct assay:GO:0052381 tRNA dimethylallyltransferase activity [PMID:18852462|PMID:3031456]" /experiment="EXISTENCE:mutant phenotype:GO:0006400 tRNA modification [PMID:3031456]" /note="Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; also has a role in tRNA gene-mediated silencing; gene encodes two isozymic forms; converts to a prion form, prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; homolog of human TRIT1, a mutation in which is associated with severe combined respiratory chain defects" /db_xref="GeneID:854448" /db_xref="SGD:S000005800" ORIGIN 1 mlkgplkgcl nmskkvivia gttgvgksql siqlaqkfng evinsdsmqv ykdipiitnk 61 hplqeregip hhvmnhvdws eeyyshrfet ecmnaiedih rrgkipivvg gthyylqtlf 121 nkrvdtksse rkltrkqldi lestdpdviy ntlvkcdpdi atkyhpndyr rvqrmleiyy 181 ktgkkpsetf neqkitlkfd tlflwlyskp eplfqrlddr vddmlergal qeikqlyeyy 241 sqnkftpeqc engvwqvigf keflpwltgk tddntvkled ciermktrtr qyakrqvkwi 301 kkmlipdikg diylldatdl sqwdtnasqr aiaisndfis nrpikqerap kaleellskg 361 ettmkklddw thytcnvcrn adgknvvaig ekywkihlgs rrhksnlkrn trqadfekwk 421 inkketve // LOCUS NP_014918 661 aa linear PLN 30-JUN-2025 DEFINITION Rim20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014918 VERSION NP_014918.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183694.1 REFERENCE 1 (residues 1 to 661) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 661) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 661) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 661) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 661) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11041. Method: conceptual translation. FEATURES Location/Qualifiers source 1..661 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..661 /product="Rim20p" /calculated_mol_wt="75817" Region 3..343 /region_name="BRO1_ScRim20-like" /note="Protein-interacting, N-terminal, Bro1-like domain of Saccharomyces cerevisiae Rim20 and related proteins; cd09241" /db_xref="CDD:185764" Site order(117,120,133,136..137,182,185..186,195,198..199,311, 313,315,317) /site_type="other" /note="putative ESCRT-III binding site" /db_xref="CDD:185764" Region 338..645 /region_name="V_Alix_like" /note="Protein-interacting V-domain of mammalian Alix and related domains; cd08915" /db_xref="CDD:185746" Site order(402,461,465,468..469,616,619..620,623,626) /site_type="other" /note="putative YPXnL-motif binding site" /db_xref="CDD:185746" CDS 1..661 /gene="RIM20" /locus_tag="YOR275C" /coded_by="NM_001183694.1:1..1986" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0016485 protein processing [PMID:11698381]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:18202364|PMID:11698381]" /experiment="EXISTENCE:mutant phenotype:GO:0016485 protein processing [PMID:11698381]" /experiment="EXISTENCE:mutant phenotype:GO:0030435 sporulation resulting in formation of a cellular spore [PMID:11698381]" /note="Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation; localizes to cytosol, nucleus and peroxisomes" /db_xref="GeneID:854449" /db_xref="SGD:S000005801" ORIGIN 1 msellaiplk rtlevdfate lsklidttsf qtasffqsdi lkvvdarnna iapdisidgl 61 salkeyyvil lqlekkfpnn qieftwfqtl sqksrgtsqy slqwekltii ynigcmysll 121 alnsnndaae slktsclyfq naagcfkhvl dhqknletip vvddatlnal tslmlaqaqe 181 cfwfkavqdk hkdsliakls qqivdfycea indaqrgkli rsdwinhlka kkayfsavty 241 yrialsfnek kqfgnvvkal qmglqfines tlssqakfkt vvesslkeaq rdnefiylqe 301 vpselpsikp almvkpsssa tllpsikkde tlfkdlipie vmeyctayne rqdeyveqrv 361 tnplaslnkl lkeslttfqi pqgltkvsea elshyqasln nllinnknvq vqldnieqil 421 neeaftdnql rlkhgtlnwt lpessttnta yyeklkklrg yldegsaidk qtnelfqsid 481 knligseirl pesndpltnk ikmiiqernd yidrtrrkss eyrilpkiit sykkngtvdf 541 epifighlky fdedlryvns tkeeniklie evnlskknnp grsgiepkkm vridprelyi 601 edlrysfkll devkenlsag tafyenlits tsnlynevqe ydtarraeka rldksltfed 661 q // LOCUS NP_014919 161 aa linear PLN 30-JUN-2025 DEFINITION Caf20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014919 VERSION NP_014919.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183695.3 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11042. On Jul 30, 2012 this sequence version replaced NP_014919.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..161 /product="Caf20p" /calculated_mol_wt="18092" Region 3..153 /region_name="CAF20" /note="Cap associated factor; pfam17052" /db_xref="CDD:407224" CDS 1..161 /gene="CAF20" /locus_tag="YOR276W" /gene_synonym="CAF2; CAP20" /coded_by="NM_001183695.3:1..486" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008190 eukaryotic initiation factor 4E binding [PMID:9707439]" /experiment="EXISTENCE:direct assay:GO:0017148 negative regulation of translation [PMID:9118949]" /experiment="EXISTENCE:mutant phenotype:GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly [PMID:18182159]" /experiment="EXISTENCE:mutant phenotype:GO:0017148 negative regulation of translation [PMID:9144215]" /experiment="EXISTENCE:mutant phenotype:GO:0030447 filamentous growth [PMID:17041186]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:17041186]" /note="Phosphoprotein of the mRNA cap-binding complex; involved in translational control; repressor of cap-dependent translational initiation; translational activator of select mRNAs during filamentous growth; competes with eIF4G for binding to eIF4E" /db_xref="GeneID:854450" /db_xref="SGD:S000005802" ORIGIN 1 mikytidelf qlkpsltlev nfdavefrai iekvkqlqhl keeefnshhv ghfgrrrssh 61 hhgrpkikhn kpkvttdsdg wctfeakkkg sgeddeeete ttptstvpva tiaqetlkvk 121 pnnknissnr padtrdivad kpilgfnafa alesededde a // LOCUS NP_014921 275 aa linear PLN 30-JUN-2025 DEFINITION uroporphyrinogen-III synthase HEM4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014921 VERSION NP_014921.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183697.1 REFERENCE 1 (residues 1 to 275) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 275) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 275) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 275) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 275) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11043. Method: conceptual translation. FEATURES Location/Qualifiers source 1..275 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..275 /product="uroporphyrinogen-III synthase HEM4" /EC_number="4.2.1.75" /calculated_mol_wt="30781" Site order(13,69..71,103,153,177,179,209..213) /site_type="active" /db_xref="CDD:119440" Region 26..266 /region_name="HEM4" /note="Uroporphyrinogen-III synthase HemD; pfam02602" /db_xref="CDD:426866" CDS 1..275 /gene="HEM4" /locus_tag="YOR278W" /gene_synonym="SLU2" /coded_by="NM_001183697.1:1..828" /experiment="EXISTENCE:mutant phenotype:GO:0004852 uroporphyrinogen-III synthase activity [PMID:7597845]" /experiment="EXISTENCE:mutant phenotype:GO:0006783 heme biosynthetic process [PMID:14559249|PMID:18042043]" /note="Uroporphyrinogen III synthase; catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria" /db_xref="GeneID:854452" /db_xref="SGD:S000005804" ORIGIN 1 mssrkkvrvl llknktvpid kyelecrska fepifvplik hthviqdfrn vlntipnyln 61 tinyiiitsq rtveslneai iptltseqka allsktvytv gpatanfirr sgfinvkgge 121 dagngsilad iiiddlstdi kacppsellf lvgeirrdii pkklhskgik vrevvtykte 181 elsdgfkrfi hamkecdede vfsdwvvvfs pqgtkeitqy lgdsnrlpgs hlrvasigpt 241 tkkylddndv tsdvvspkpd pkslldaiel yqrhk // LOCUS NP_014922 310 aa linear PLN 30-JUN-2025 DEFINITION Rfm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014922 VERSION NP_014922.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183698.3 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11044. On Jul 30, 2012 this sequence version replaced NP_014922.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..310 /product="Rfm1p" /calculated_mol_wt="35064" CDS 1..310 /gene="RFM1" /locus_tag="YOR279C" /coded_by="NM_001183698.3:1..933" /experiment="EXISTENCE:genetic interaction:GO:0032298 positive regulation of DNA-templated DNA replication initiation [PMID:18990212]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12612074]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:12612074]" /experiment="EXISTENCE:physical interaction:GO:0000118 histone deacetylase complex [PMID:12612074]" /experiment="EXISTENCE:physical interaction:GO:0030674 protein-macromolecule adaptor activity [PMID:12612074]" /note="Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication" /db_xref="GeneID:854453" /db_xref="SGD:S000005805" ORIGIN 1 mstnteiikn sdlqslindk rrlineikdf nksikplefe syqdyflikt fkkgisasgh 61 vdidslrnke ygiyykkikr nstqevgepi prntssssss trsnssadis dteysgentp 121 tttgaasrrr rtrsraiqre nslpaslpsi seanannddv tiseingsel pfpipiseve 181 nidiasdite rdgirrrssr iserdkrrsq srlgseedee gdghdgdege tkiqdlyesl 241 vpkilesrrr sdwilppkar ytpekqmrtk psfksikine lvgnkrirsi lsrfeggvag 301 irkrdwdstq // LOCUS NP_014923 266 aa linear PLN 30-JUN-2025 DEFINITION putative serine hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014923 VERSION NP_014923.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183699.1 REFERENCE 1 (residues 1 to 266) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 266) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 266) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 266) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 266) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11045. Method: conceptual translation. FEATURES Location/Qualifiers source 1..266 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..266 /product="putative serine hydrolase" /calculated_mol_wt="30287" Region 2..220 /region_name="FSH1" /note="Serine hydrolase (FSH1); pfam03959" /db_xref="CDD:461110" CDS 1..266 /gene="FSH3" /locus_tag="YOR280C" /coded_by="NM_001183699.1:1..801" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /note="Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; localizes to cytosol and peroxisomes; similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2" /db_xref="GeneID:854454" /db_xref="SGD:S000005806" ORIGIN 1 msekkkvlml hgfvqsdkif saktgglrkn lkklgydlyy pcaphsidkk alfqsesekg 61 rdaakefnts atsdevygwf frnpesfnsf qidqkvfnyl rnyvlengpf dgvigfsqga 121 glggylvtdf nrilnltdeq qpalkffisf sgfkledqsy qkeyhriiqv pslhvrgeld 181 evvaesrima lyeswpdnkr tllvhpgahf vpnskpfvsq vcnwiqgits kegqehnaqp 241 evdrkqfdkp qleddlldmi dslgkl // LOCUS NP_014924 286 aa linear PLN 30-JUN-2025 DEFINITION Plp2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014924 VERSION NP_014924.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183700.3 REFERENCE 1 (residues 1 to 286) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 286) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 286) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 286) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 286) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11046. On Jul 30, 2012 this sequence version replaced NP_014924.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..286 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..286 /product="Plp2p" /calculated_mol_wt="32662" Region 17..225 /region_name="Phd_like_VIAF" /note="Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human...; cd02988" /db_xref="CDD:239286" Site order(17,20..23,26,28..29,31,80,84,193,196..200,223..225) /site_type="other" /note="putative G protein beta interface [polypeptide binding]" /db_xref="CDD:239286" CDS 1..286 /gene="PLP2" /locus_tag="YOR281C" /coded_by="NM_001183700.3:1..861" /experiment="EXISTENCE:direct assay:GO:0003779 actin binding [PMID:19501098]" /experiment="EXISTENCE:direct assay:GO:0006457 protein folding [PMID:19501098]" /experiment="EXISTENCE:direct assay:GO:0031683 G-protein beta/gamma-subunit complex binding [PMID:10749875]" /experiment="EXISTENCE:mutant phenotype:GO:0003779 actin binding [PMID:19501098]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10749875]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:10749875]" /experiment="EXISTENCE:physical interaction:GO:0005737 cytoplasm [PMID:10749875]" /note="Protein that interacts with the CCT complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP; CCT is short for chaperonin containing TCP-1; essential gene" /db_xref="GeneID:854456" /db_xref="SGD:S000005807" ORIGIN 1 mqnepmfqvq vdesedsewn dilrakgvip erapsptakl eealeeaiak qhenrledkd 61 lsdleeledd ededfleayk ikrlneirkl qerskfgevf hinkpeynke vtlasqgkky 121 egaqtndnge eddggvyvfv hlslqsklqs rilshlfqsa ackfreikfv eipanraien 181 ypesncptli vyyrgevikn mitllelggn nskmedfedf mvkvgavaeg dnrlimnrdd 241 eesreerklh ygekksirsg irgkfnvgig gnddgnindd ddgffd // LOCUS NP_014926 230 aa linear PLN 30-JUN-2025 DEFINITION phosphoglycerate mutase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014926 VERSION NP_014926.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183702.1 REFERENCE 1 (residues 1 to 230) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 230) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 230) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 230) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 230) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11047. Method: conceptual translation. FEATURES Location/Qualifiers source 1..230 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..230 /product="phosphoglycerate mutase" /calculated_mol_wt="26046" Region 19..214 /region_name="His_Phos_1" /note="Histidine phosphatase superfamily (branch 1); pfam00300" /db_xref="CDD:459751" CDS 1..230 /locus_tag="YOR283W" /coded_by="NM_001183702.1:1..693" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016311 dephosphorylation [PMID:19753119]" /experiment="EXISTENCE:direct assay:GO:0016791 phosphatase activity [PMID:19753119|PMID:20427268]" /note="Phosphatase with a broad substrate specificity; has some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene" /db_xref="GeneID:854457" /db_xref="SGD:S000005809" ORIGIN 1 mtkevpyycd nddnniirlf iirhgqtehn vkkilqghkd tsinptgeeq atklghylrs 61 rgihfdkvvs sdlkrcrqtt alvlkhskqe nvptsytsgl rerymgvieg mqiteaekya 121 dkhgegsfrn fgeksddfva rltgcveeev aeasnegvkn lalvshggai rmilqwlkye 181 nhqahkiivf ntsvtivdyv kdskqfivrr vgntqhlgdg efvvsdlrlr // LOCUS NP_014927 243 aa linear PLN 30-JUN-2025 DEFINITION Hua2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014927 VERSION NP_014927.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183703.3 REFERENCE 1 (residues 1 to 243) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 243) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 243) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 243) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 243) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11048. On Jul 30, 2012 this sequence version replaced NP_014927.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..243 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..243 /product="Hua2p" /calculated_mol_wt="28283" CDS 1..243 /gene="HUA2" /locus_tag="YOR284W" /coded_by="NM_001183703.3:1..732" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic hypothetical protein; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly" /db_xref="GeneID:854458" /db_xref="SGD:S000005810" ORIGIN 1 mqqtkfgkmy ldhdsvveys edeiveadri tlgykkrlsm ienqmrhlle dfsldvqqie 61 piladlqkyy daflqllqkr nkslqckrst hqpvpspmns qtstnakvnl sgklmkfqln 121 svqkfdeeni lrilqnkief ehyfqidkgk kqkvlllavy qclngptrlh kvlniegiih 181 nnsirtilgk qvssskwtvf lydvklvlla hrqdvpnlet skmivrygdl fpcalyfkdh 241 tay // LOCUS NP_014928 139 aa linear PLN 30-JUN-2025 DEFINITION thiosulfate sulfurtransferase RDL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014928 VERSION NP_014928.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183704.1 REFERENCE 1 (residues 1 to 139) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 139) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 139) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 139) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11049. Method: conceptual translation. FEATURES Location/Qualifiers source 1..139 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..139 /product="thiosulfate sulfurtransferase RDL1" /calculated_mol_wt="15282" Region 25..131 /region_name="RHOD_HSP67B2" /note="Member of the Rhodanese Homology Domain superfamily. This CD includes the heat shock protein 67B2 of Drosophila melanogaster and other similar proteins, many of which are uncharacterized; cd01519" /db_xref="CDD:238777" Site 98 /site_type="active" /note="active site residue [active]" /db_xref="CDD:238777" CDS 1..139 /gene="RDL1" /locus_tag="YOR285W" /coded_by="NM_001183704.1:1..420" /experiment="EXISTENCE:direct assay:GO:0004792 thiosulfate-cyanide sulfurtransferase activity [PMID:24981631]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006790 sulfur compound metabolic process [PMID:30217845]" /note="Thiosulfate sulfurtransferase; contains a rhodanese-like domain; localized to the mitochondrial outer membrane; protein abundance increases in response to DNA replication stress; similar to the human TSTD gene" /db_xref="GeneID:854459" /db_xref="SGD:S000005811" ORIGIN 1 mwkavmnawn gtesqsknvs niqsysfedm krivgkhdpn vvlvdvreps eysivhipas 61 invpyrshpd afaldplefe kqigipkpds akelifycas gkrggeaqkv asshgysnts 121 lypgsmndwv shggdkldl // LOCUS NP_014929 149 aa linear PLN 30-JUN-2025 DEFINITION thiosulfate sulfurtransferase RDL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014929 VERSION NP_014929.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183705.3 REFERENCE 1 (residues 1 to 149) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 149) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 149) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 149) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 149) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11050. On Jul 30, 2012 this sequence version replaced NP_014929.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..149 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..149 /product="thiosulfate sulfurtransferase RDL2" /EC_number="2.8.1.1" /calculated_mol_wt="16566" Region 33..139 /region_name="RHOD_HSP67B2" /note="Member of the Rhodanese Homology Domain superfamily. This CD includes the heat shock protein 67B2 of Drosophila melanogaster and other similar proteins, many of which are uncharacterized; cd01519" /db_xref="CDD:238777" Site 106 /site_type="active" /note="active site residue [active]" /db_xref="CDD:238777" CDS 1..149 /gene="RDL2" /locus_tag="YOR286W" /gene_synonym="AIM42" /coded_by="NM_001183705.3:1..450" /experiment="EXISTENCE:direct assay:GO:0004792 thiosulfate-cyanide sulfurtransferase activity [PMID:19864628]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006790 sulfur compound metabolic process [PMID:30217845]" /note="Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss" /db_xref="GeneID:854460" /db_xref="SGD:S000005812" ORIGIN 1 mfkhstgils rtvsarsptl vlrtfttkap kiytfdqvrn lvehpndkkl lvdvrepkev 61 kdykmpttin ipvnsapgal glpekefhkv fqfakpphdk eliflcakgv raktaeelar 121 sygyentgiy pgsitewlak ggadvkpkk // LOCUS NP_014930 300 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein RRP36 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014930 VERSION NP_014930.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183706.1 REFERENCE 1 (residues 1 to 300) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 300) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 300) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 300) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11051. Method: conceptual translation. FEATURES Location/Qualifiers source 1..300 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..300 /product="rRNA-processing protein RRP36" /calculated_mol_wt="35994" Region <6..142 /region_name="COG5593" /note="Nucleic-acid-binding protein possibly involved in ribosomal biogenesis [Translation, ribosomal structure and biogenesis]" /db_xref="CDD:227880" Region 120..285 /region_name="RRP36" /note="rRNA biogenesis protein RRP36; pfam06102" /db_xref="CDD:461829" CDS 1..300 /gene="RRP36" /locus_tag="YOR287C" /coded_by="NM_001183706.1:1..903" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:20038530]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:20038530]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12837249]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:20038530]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:20038530]" /note="Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit" /db_xref="GeneID:854461" /db_xref="SGD:S000005813" ORIGIN 1 msyyfknlkp dlnsdveedd gnllesiman kskreideqe ssddelktls fgslkkaetv 61 ideedfkdtk pvhkkpittt yreesfdede dsedqsdeda gffeedsede thhgqkvpkk 121 kskhapveqs skkrvprvrn ipgleiprnk rsnlyqdirf dkstgkalds siirkryqfl 181 deyrekeide lqkllqerkf lskidqgere emeqrlksmk srlqsmknkd lereilkeye 241 ndmnknnntr yhlkksekrk vvqkwkfdhm kakqrekvme rkrkkrlgke fkqfefhnrr // LOCUS NP_014931 318 aa linear PLN 30-JUN-2025 DEFINITION protein disulfide isomerase MPD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014931 VERSION NP_014931.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183707.3 REFERENCE 1 (residues 1 to 318) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 318) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 318) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 318) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11052. On Jul 30, 2012 this sequence version replaced NP_014931.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..318 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..318 /product="protein disulfide isomerase MPD1" /EC_number="5.3.4.1" /calculated_mol_wt="36277" Region 30..>275 /region_name="ER_PDI_fam" /note="protein disulfide isomerase, eukaryotic; TIGR01130" /db_xref="CDD:273457" Region 30..150 /region_name="PDI_a_MPD1_like" /note="PDI family, MPD1-like subfamily; composed of eukaryotic proteins similar to Saccharomyces cerevisiae MPD1 protein, which contains a single redox active TRX domain located at the N-terminus, and an ER retention signal at the C-terminus indicative of an...; cd03002" /db_xref="CDD:239300" Site order(59,62,140) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:239300" CDS 1..318 /gene="MPD1" /locus_tag="YOR288C" /coded_by="NM_001183707.3:1..957" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0003756 protein disulfide isomerase activity [PMID:16002399]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015035 protein-disulfide reductase activity [PMID:16002399]" /experiment="EXISTENCE:direct assay:GO:0019153 protein-disulfide reductase (glutathione) activity [PMID:16002399]" /experiment="EXISTENCE:genetic interaction:GO:0003756 protein disulfide isomerase activity [PMID:11157982]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:11157982]" /experiment="EXISTENCE:genetic interaction:GO:0015035 protein-disulfide reductase activity [PMID:11157982]" /experiment="EXISTENCE:mutant phenotype:GO:0003756 protein disulfide isomerase activity [PMID:11157982]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:16002399]" /note="Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation" /db_xref="GeneID:854462" /db_xref="SGD:S000005814" ORIGIN 1 mlflniikll lglfimnevk aqnfydsdph iseltpksfd kaihntnyts lvefyapwcg 61 hckklsstfr kaakrldgvv qvaavncdln knkalcakyd vngfptlmvf rppkidlskp 121 idnakksfsa hanevysgar tlapivdfsl srirsyvkkf vridtlgsll rkspklsvvl 181 fskqdkispv yksialdwlg kfdfysisnk klkqltdmnp tyektpeifk ylqkvipeqr 241 qsdksklvvf dadkdkfwey egnsinkndi skflrdtfsi tpnegpfsrr seyiaylktg 301 kkpikknhss sgnkhdel // LOCUS NP_014932 251 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR289W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014932 VERSION NP_014932.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183708.1 REFERENCE 1 (residues 1 to 251) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 251) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 251) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 251) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 251) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11053. Method: conceptual translation. FEATURES Location/Qualifiers source 1..251 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..251 /product="uncharacterized protein" /calculated_mol_wt="28968" Region 12..251 /region_name="TIGR00296" /note="uncharacterized protein, PH0010 family" /db_xref="CDD:273002" CDS 1..251 /locus_tag="YOR289W" /coded_by="NM_001183708.1:1..756" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /db_xref="GeneID:854463" /db_xref="SGD:S000005815" ORIGIN 1 malrlfrkss ffakismegp kgsspfafya fyqlyshlnp gkssslsled irrrlypdfk 61 idynektslf itwkkksnkh htidtneeny ilrgcigtfa kmpiahgiek ysliaaledr 121 rfspiqkrel vdlkcscnil gnfktifrgg gnpngdifdw elgkhgiely fkhpktgttc 181 satflpdvmp eqhwnkedtf anliekagyw gnisevmdnf etyfieviry egkkssitye 241 efnkqlkdie a // LOCUS NP_014933 1703 aa linear PLN 30-JUN-2025 DEFINITION SWI/SNF catalytic subunit SNF2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014933 VERSION NP_014933.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183709.3 REFERENCE 1 (residues 1 to 1703) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1703) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1703) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1703) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1703) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1703) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1703) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1703) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1703) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11054. On Jul 30, 2012 this sequence version replaced NP_014933.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1703 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1703 /product="SWI/SNF catalytic subunit SNF2" /calculated_mol_wt="193921" Region 248..281 /region_name="QLQ" /note="pfam08880" /db_xref="CDD:462622" Region <617..656 /region_name="HSA" /note="HSA domain; pfam07529" /db_xref="CDD:462194" Region 650..>1297 /region_name="PLN03142" /note="Probable chromatin-remodeling complex ATPase chain; Provisional" /db_xref="CDD:215601" Region 1303..1369 /region_name="SnAC" /note="Snf2-ATP coupling, chromatin remodelling complex; pfam14619" /db_xref="CDD:464219" Region 1550..1652 /region_name="Bromo_SNF2" /note="Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of...; cd05519" /db_xref="CDD:99950" Site order(1580,1585,1588,1627,1631,1637) /site_type="other" /note="putative acetyllysine binding site [chemical binding]" /db_xref="CDD:99950" CDS 1..1703 /gene="SNF2" /locus_tag="YOR290C" /gene_synonym="GAM1; HAF1; SWI2; TYE3" /coded_by="NM_001183709.3:1..5112" /experiment="EXISTENCE:direct assay:GO:0000182 rDNA binding [PMID:23437238]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:1901413|PMID:22932476|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:8016655]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:18644858|PMID:8159677|PMID:8016655|PMID:8127913]" /experiment="EXISTENCE:direct assay:GO:0031492 nucleosomal DNA binding [PMID:18644858]" /experiment="EXISTENCE:direct assay:GO:0140015 histone H3K14ac reader activity [PMID:20126658]" /experiment="EXISTENCE:direct assay:GO:0140658 ATP-dependent chromatin remodeler activity [PMID:8127913|PMID:8458575]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:1459453]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1901413]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:10198436]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:16024655]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:1459453|PMID:8016655]" /experiment="EXISTENCE:mutant phenotype:GO:0016514 SWI/SNF complex [PMID:8159677]" /experiment="EXISTENCE:mutant phenotype:GO:0031496 positive regulation of mating type switching [PMID:6436497]" /experiment="EXISTENCE:mutant phenotype:GO:0034198 cellular response to amino acid starvation [PMID:10549298]" /experiment="EXISTENCE:mutant phenotype:GO:0035973 aggrephagy [PMID:31846549]" /experiment="EXISTENCE:mutant phenotype:GO:0042148 DNA strand invasion [PMID:19766565]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1339306|PMID:10549298|PMID:3542227|PMID:17681272|PMI D:8016655]" /experiment="EXISTENCE:mutant phenotype:GO:0140566 histone reader activity [PMID:12419247]" /experiment="EXISTENCE:mutant phenotype:GO:0140658 ATP-dependent chromatin remodeler activity [PMID:8016655|PMID:8458575]" /experiment="EXISTENCE:mutant phenotype:GO:1900189 positive regulation of cell adhesion involved in single-species biofilm formation [PMID:18202364]" /experiment="EXISTENCE:mutant phenotype:GO:2000219 positive regulation of invasive growth in response to glucose limitation [PMID:18202364]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:11865042]" /note="Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p" /db_xref="GeneID:854465" /db_xref="SGD:S000005816" ORIGIN 1 mnipqrqfsn eevnrcylrw qhlrnehgmn apsvpefiyl tkvlqfaakq rqelqmqrqq 61 qgisgsqqni vpnssdqael pnnasshisa sasphlapnm qlngnetfst sahqspimqt 121 qmplnsnggn nmlpqrqssv gslnatnfsp tpanngenaa ekpdnsnhnn lnlnnselqp 181 qnrslqehni qdsnvmpgsq inspmpqqaq mqqaqfqaqq aqqaqqaqqa qqaqarlqqg 241 rrlpmtmfta eqsellkaqi tslkclvnrk pipfefqavi qksinhppdf krmllslsef 301 arrrqptdqn nqsnlnggnn tqqpgtnshy nntntdnvsg ltrnapldsk denfasvspa 361 gpssvhnakn gtldknsqtv sgtpitqtes kkeenetisn vaktapnsnk thteqnnppk 421 pqkpvplnvl qdqykegikv vdiddpdmmv dsftmpnish snidyqtlla nsdhakftie 481 pgvlpvgidt htatdiyqtl ialnldttvn dcldkllnde ctestrenal ydyyalqllp 541 lqkavrghvl qfewhqnsll tnthpnflsk irninvqdal ltnqlyknhe llklerkkte 601 avarlksmnk sainqynrrq dkknkrlkfg hrliathtnl erdeqkraek kakerlqalk 661 andeeayikl ldqtkdtrit hllrqtnafl dsltravkdq qkytkemids hikeaseevd 721 dlsmvpkmkd eeydddddns nvdyynvahr ikedikkqps ilvggtlkdy qikglqwmvs 781 lfnnhlngil ademglgkti qtislltyly emknirgpyl vivplstlsn wssefakwap 841 tlrtisfkgs pnerkakqak iragefdvvl ttfeyiiker allskvkwvh miideghrmk 901 naqsklsltl nthyhadyrl iltgtplqnn lpelwallnf vlpkifnsvk sfdewfntpf 961 antggqdkie lseeetllvi rrlhkvlrpf llrrlkkdve kelpdkvekv vkckmsalqq 1021 imyqqmlkyr rlfigdqnnk kmvglrgfnn qimqlkkicn hpfvfeeved qinptretnd 1081 diwrvagkfe lldrilpklk atghrvliff qmtqimdime dflryiniky lrldghtksd 1141 ersellrlfn apdseylcfi lstragglgl nlqtadtvii fdtdwnphqd lqaqdrahri 1201 gqknevrilr littnsveev ileraykkld idgkviqagk fdnkstseeq eallrsllda 1261 eeerrkkres gveeeeelkd seineilarn deemavltrm dedrskkeee lgvksrllek 1321 selpdiysrd igaelkrees esaavyngrg arerktatyn dnmseeqwlr qfevsddekn 1381 dkqarkqrtk kedkseaidg ngeikgenid adndgprinn isaedradtd lamndddfls 1441 kkrkagrprg rpkkvklegs enseppales spvtgdnsps edfmdipkpr tagktsvksa 1501 rtstrgrgrg rgrgrgrgrg rgrppkarng ldyvrtpaaa tspidirekv akqaldlyhf 1561 alnyeneagr klsdiflskp skalypdyym iikypvafdn inthietlay nslketlqdf 1621 hlifsnariy ntegsvvyed slelekvvtk kyceimgdns qldftefdeq ygtrplvlpp 1681 vvtssvaesf tdeadssmte asv // LOCUS NP_014934 1472 aa linear PLN 30-JUN-2025 DEFINITION putative acid anhydride hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014934 VERSION NP_014934.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183710.1 REFERENCE 1 (residues 1 to 1472) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1472) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1472) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1472) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1472) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11055. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1472 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1472 /product="putative acid anhydride hydrolase" /calculated_mol_wt="166620" Region 307..1431 /region_name="P-ATPase-V" /note="P-type ATPase of unknown pump specificity (type V); TIGR01657" /db_xref="CDD:273738" CDS 1..1472 /gene="YPK9" /locus_tag="YOR291W" /coded_by="NM_001183710.1:1..4419" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347|PMID:19182805]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /note="Vacuolar protein; involved in oxidative stress response and modulation of replicative lifespan; targeted to vacuole via AP-3 pathway; undergoes autophosphorylation, which is abolished by mutation of Asp781 in catalytic motif (D781N); P5 ATPase subfamily member with similarity to yeast Spf1p and homology to human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome" /db_xref="GeneID:854466" /db_xref="SGD:S000005817" ORIGIN 1 mdipssnqiq hgqrsernrr mprasfssta ttstaatlts amvldqnnse pyagatfeav 61 pssivsfhhp hsfqssnlps phssgnleqr grrltesepl vlssaeqsrs ssrnpshfrf 121 ftqeqisnae gastlentdy dmawdatpay eqdriygtgl ssrrssirsf srasslsnak 181 sygsfskrgr sgsrapqrlg ensdtgfvyh sathssssls ryttreripi elesqtdeil 241 edessthsle ssdsrrsase nnrgsfsghd dvhnqhseyl kpdyhekfyp qyapnlhyqr 301 fyiaeedlvi giaayqtskf wyiiynlccf ltfglvyllt rwlphlkvkl ygvkvplaka 361 ewvvienefg efviqpidrq wynrplstvl pfenypnpsy epndinlshh haneinpnvp 421 ilitfeyryi kfiysplddl fktnnnwidp dwvdlstvsn gltkgvqedr elafgknqin 481 lrmkttseil fnevlhpfyv fqvfsiilwg ideyyyyaac iflisvlsif dslneqkkvs 541 rnlaemshfh cdvrvlrdkf wttissselv pgdiyevsdp nitilpcdsi llssdcivne 601 smltgesvpv skfpateetm yqlcddfqst qissfvsksf lyngtniira riapgqtaal 661 amvvrtgfst tkgslvrsmv fpkptgfkfy rdsfkyigfm sliaifgfcv scvqfiklgl 721 dkktmilral diitivvppa lpatltigtn falsrlkekg ifcisptrln isgkidvmcf 781 dktgtltedg ldvlgvqise pngvrgqkfg ellsdirqvf pkfslndcss pldfksrnff 841 mslltchslr svdgnllgdp ldfkmfqftg wsfeedfqkr afhslyegrh eddvfpense 901 iipavvhpds nnrentftdn dphnflgvvr sfeflselrr msvivktnnd dvywsftkga 961 peviseicnk stlpadfeev lrcythngyr viacagktlp krtwlysqkv sreevesnle 1021 flgfiifqnk lkketsetlk slqdanirti mctgdnilta isvgreagli qcsrvyvpsi 1081 ndtplhgepv ivwrdvnepd kildtktlkp vklgnnsves lrecnytlav sgdvfrllfr 1141 deneipeeyl neillnssiy armspdekhe lmiqlqkldy tvgfcgdgan dcgalkaadv 1201 gislseaeas vaapftskif niscvldvir egraalvtsf acfqymslys aiqfititil 1261 ysrgsnlgdf qflyidllli vpiaicmsws ksyekidkkr psanlvspki lvpllisvfl 1321 vflfqfipwi ivqkmswyik pivggddavq ssdntvlffv snfqyiltai vlsvgppyre 1381 pmsknfefiv ditvsigasl llmtldtesy lgkmlqltpi snsftmfiiv wvilnyyaql 1441 yippsikgwl kkkksskkyk lliqeemklk ev // LOCUS NP_014935 309 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR292C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014935 VERSION NP_014935.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183711.3 REFERENCE 1 (residues 1 to 309) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 309) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 309) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 309) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 309) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11056. On Jul 30, 2012 this sequence version replaced NP_014935.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..309 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..309 /product="uncharacterized protein" /calculated_mol_wt="36064" Region 243..303 /region_name="Mpv17_PMP22" /note="Mpv17 / PMP22 family; pfam04117" /db_xref="CDD:461182" CDS 1..309 /locus_tag="YOR292C" /coded_by="NM_001183711.3:1..930" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene" /db_xref="GeneID:854467" /db_xref="SGD:S000005818" ORIGIN 1 mplqlfgrdq ivvhydngnm snddqnhqsv lgswtrraaa alrtlmnkri qritlthwll 61 lviwvtslwk ftshyrqlya nsavfatlct nillfgisdi laqsiacfys yhvdpipqil 121 ndtfhhvqnn rdvengggye sdelsifndf tsehssytdn ddypeldrpl atfktdtfdf 181 frwgcfmfwg ffisffqapw ykflnffyte dptvvqvfer vlsdqllysp islycffmfs 241 nyvmeggdkd tlgkkiqrly istlgcnylv wpmvqfinfl imprdfqapf sssvgvvwnc 301 flsmrnask // LOCUS NP_014936 105 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS10 RPS10A [Saccharomyces cerevisiae S288C]. ACCESSION NP_014936 VERSION NP_014936.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183712.1 REFERENCE 1 (residues 1 to 105) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 105) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 105) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 105) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 105) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11057. Method: conceptual translation. FEATURES Location/Qualifiers source 1..105 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..105 /product="40S ribosomal protein eS10 RPS10A" /calculated_mol_wt="12608" Region 1..105 /region_name="COG5045" /note="Ribosomal protein S10E [Translation, ribosomal structure and biogenesis]" /db_xref="CDD:227378" CDS 1..105 /gene="RPS10A" /locus_tag="YOR293W" /coded_by="NM_001183712.1:1..318" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication; mutations in the human homolog associated with Diamond-Blackfan anemia" /db_xref="GeneID:854468" /db_xref="SGD:S000005819" ORIGIN 1 mlmpkedrnk ihqylfqegv vvakkdfnqa kheeidtknl yvikalqslt skgyvktqfs 61 wqyyyytlte egveylreyl nlpehivpgt yiqernptqr pqrry // LOCUS NP_878174 49 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR293C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878174 VERSION NP_878174.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184669.3 REFERENCE 1 (residues 1 to 49) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 49) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 49) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 49) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 49) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11058. On Jul 30, 2012 this sequence version replaced NP_878174.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..49 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..49 /product="uncharacterized protein" /calculated_mol_wt="5993" CDS 1..49 /locus_tag="YOR293C-A" /coded_by="NM_001184669.3:1..150" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466486" /db_xref="SGD:S000028858" ORIGIN 1 mkllflniiv vrrhlhcksy rlspwyiyiy gdyllyttei pykpftrqp // LOCUS NP_014937 203 aa linear PLN 30-JUN-2025 DEFINITION ribosome biogenesis protein RRS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014937 VERSION NP_014937.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183713.1 REFERENCE 1 (residues 1 to 203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 203) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11059. Method: conceptual translation. FEATURES Location/Qualifiers source 1..203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..203 /product="ribosome biogenesis protein RRS1" /calculated_mol_wt="22832" Region 9..203 /region_name="RRS1" /note="Uncharacterized protein involved in ribosome biogenesis [Translation, ribosomal structure and biogenesis]; COG5225" /db_xref="CDD:227550" CDS 1..203 /gene="RRS1" /locus_tag="YOR294W" /coded_by="NM_001183713.1:1..612" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:10688653]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10688653]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17938242|PMID:17443350]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:21822217]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:15135061]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10688653]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:10688653]" /note="Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice" /db_xref="GeneID:854469" /db_xref="SGD:S000005820" ORIGIN 1 msaedyknlp vtvekpipvv ydlgnlaafd snvldkndld ssnarreeki ksltrdnvql 61 linqllslpm ktttesvggt ggqssvmtll qlpdpttdlp rekplpkaka mtkwekfaak 121 kgikpkerag kmiydeasge wvpkwgykga nkklddqwlv evddkvkgtd nelidprtln 181 raerkrlvkk nekqqrrnmk nal // LOCUS NP_014938 228 aa linear PLN 30-JUN-2025 DEFINITION Uaf30p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014938 VERSION NP_014938.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183714.3 REFERENCE 1 (residues 1 to 228) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 228) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 228) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 228) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11060. On Jul 30, 2012 this sequence version replaced NP_014938.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..228 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..228 /product="Uaf30p" /calculated_mol_wt="25836" Region 6..55 /region_name="DEK_C" /note="DEK C terminal domain; pfam08766" /db_xref="CDD:462592" Region 120..195 /region_name="SWIB" /note="SWI complex, BAF60b domains; smart00151" /db_xref="CDD:128456" Site order(142,145..146,148..149,152..153,158,163..164,166, 185..186) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:349489" CDS 1..228 /gene="UAF30" /locus_tag="YOR295W" /coded_by="NM_001183714.3:1..687" /experiment="EXISTENCE:direct assay:GO:0000500 RNA polymerase I upstream activating factor complex [PMID:11500378]" /experiment="EXISTENCE:direct assay:GO:0001165 RNA polymerase I cis-regulatory region sequence-specific DNA binding [PMID:18451108]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22362748]" /experiment="EXISTENCE:mutant phenotype:GO:0001181 RNA polymerase I general transcription initiation factor activity [PMID:18765638]" /experiment="EXISTENCE:mutant phenotype:GO:0006325 chromatin organization [PMID:20154141]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:18765638|PMID:11500378]" /note="Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication" /db_xref="GeneID:854470" /db_xref="SGD:S000005821" ORIGIN 1 maelndystm idillsdmdl etvttkkvrm alkevyaidv esqgkainkl irkhldlvke 61 rprfersled llkenatlai eltkeitvsk rssgeeknds etkgthvekk kgtvskspis 121 trkvtlsksl asllgehelt rtevvrrlwa yikahnlqnp nnkkeilcde klelilgkst 181 nmfemhkila shmtepkkis dcppliqevr rkekpivsds eqsdtkgi // LOCUS NP_014939 1289 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR296W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014939 VERSION NP_014939.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183715.1 REFERENCE 1 (residues 1 to 1289) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1289) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1289) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1289) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1289) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11061. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1289 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1289 /product="uncharacterized protein" /calculated_mol_wt="147296" Region 856..986 /region_name="C2_Munc13_fungal" /note="C2 domain in Munc13 (mammalian uncoordinated) proteins; fungal group; cd04043" /db_xref="CDD:176008" CDS 1..1289 /locus_tag="YOR296W" /coded_by="NM_001183715.1:1..3870" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene" /db_xref="GeneID:854471" /db_xref="SGD:S000005822" ORIGIN 1 mnrtvstlss tvsdvsveip sicnvintel ptsdvylytl klilldyine prfkeaalls 61 nrtgtsrvls dktnhqqtqh gkklvvdkqd dmserdivqa tlrilkgkla qisgnknlap 121 nemhwksivk myysmldsss adtfskmgqm eevvgyftni asnelkkmti knsrdelfse 181 vayfidlvid vlpdscanii krlldykinl kkgettvkkk raaspatvpq yrsisgstis 241 nkqpsfkvqd ishmkyfmql fetdetklhq dvmavkddct npifcgelry lrkkikkdng 301 tltasdfssd reynlwknye lleianlmdr feigekvtsh gnrlipkdak svfvrliglv 361 lkkecsnavn ainlsqealf ffhksarywr ieypstissl vysaanlsvl gdeelnipit 421 enlfsvirnk ylcsednldp sawnaqdryl waanlfhttd qsmrtinnll taifsgtkpk 481 fspvlsfyys nivgdpvmef yetqsvavkk ywiklfkktl fkasedyfvs llqdmlkana 541 ieiqnvqnlv etiieaikai qkrynkplld eislprqcav flcevygsds lnliktaeks 601 tmkmtgqklg pidaldmydv lkelrqiylq vkpkgkfffn lenyfikylt rlcddvsrnv 661 qkvikssles enwqpvndqd hfsrsvldif kminestsml ekfgwqnefq laqmitvilk 721 afsdgmlsys aqlmeliqrd lqegdepsys lessdtrssl slnnanvnhe ksrssrlfed 781 lknvvkstpk mvapapyqfk krtcvllndl dktlfllesf eekadpskis sviaqyhssh 841 nledngksfd dqnmkqvytl riigaenikg fsktglsnty vsmrnitlqr eigttkivar 901 sitpkwdeef vfespfgksn dimftiwhhp hsrlknlaed dlcgkanmkf tprklkddgf 961 pidfsltlnp qgtlycqisl esekidavss mgriyrsfsr srdrainliv nkfsdfiafa 1021 fsrttlktvc ghhgsalasd eavydailpl fdylnanlni laselsqrll fmvmlrawnl 1081 vlenadllll palnsakvni lrsakkslwe ntlsttktvs gygrpltqae ieavfkwlda 1141 lcvdffhnkg egpplaelkn eyyqnillip afydksvsel kdevqrlipl yeeylrwfyl 1201 kktpitftnk sagtisrkks lvanivkepk eqlerdaevm niilriliak gqhdyvhril 1261 hdrkelvntm knrravsrav tptgkkgrn // LOCUS NP_014940 192 aa linear PLN 30-JUN-2025 DEFINITION Tim18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014940 VERSION NP_014940.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183716.4 REFERENCE 1 (residues 1 to 192) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 192) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 192) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 192) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 192) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11062. On Jul 30, 2012 this sequence version replaced NP_014940.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..192 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..192 /product="Tim18p" /calculated_mol_wt="21841" Region 47..180 /region_name="CybS" /note="succinate dehydrogenase cytochrome B small subunit; pfam05328" /db_xref="CDD:461624" CDS 1..192 /gene="TIM18" /locus_tag="YOR297C" /coded_by="NM_001183716.4:1..579" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:12637749]" /experiment="EXISTENCE:direct assay:GO:0042721 TIM22 mitochondrial import inner membrane insertion complex [PMID:10648604|PMID:10637294]" /experiment="EXISTENCE:genetic interaction:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:10637294]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17922641]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:17922641]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:17922641]" /experiment="EXISTENCE:mutant phenotype:GO:0046685 response to arsenic-containing substance [PMID:17922641]" /note="Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex" /db_xref="GeneID:854472" /db_xref="SGD:S000005823" ORIGIN 1 mllfpglkpv lnastvivnp vravfpglvl stkrsfysin rlnaenkind iantskeass 61 svqmfkppef sqfkdsyqkd yeriakytli pltmvpfyas ftggvinpll daslssifli 121 ylqygftsci idyipkekyp rwhklalycl yggsmlslyg iyeletknng fvdlvkklwn 181 enddhlyifg rn // LOCUS NP_014941 479 aa linear PLN 30-JUN-2025 DEFINITION Mum3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014941 VERSION NP_014941.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183717.1 REFERENCE 1 (residues 1 to 479) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 479) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 479) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 479) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11063. Method: conceptual translation. FEATURES Location/Qualifiers source 1..479 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..479 /product="Mum3p" /calculated_mol_wt="57106" Region 151..>250 /region_name="LPLAT" /note="Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; cl17185" /db_xref="CDD:473073" Region 429..>473 /region_name="Acyltransf_C" /note="Acyltransferase C-terminus; pfam16076" /db_xref="CDD:465006" CDS 1..479 /gene="MUM3" /locus_tag="YOR298W" /coded_by="NM_001183717.1:1..1440" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:15590821]" /note="hypothetical protein involved in outer spore wall organization; has similarity to the tafazzins superfamily of acyltransferases" /db_xref="GeneID:854473" /db_xref="SGD:S000005824" ORIGIN 1 mgfvdffety mvgsrvqfkq ldisdwlslt prllilfgyf ylhsfftain qflqfintns 61 fclrlhllyd rfwshvpiig eykirllsra ltysklkiip tldkvleaie iwfqlhlvem 121 tfekkknvqi fitegsddln ffkdskfqtt lmicnhrsvn dytlinylfl kscptkfytk 181 weflqklrkg edlaewpqlk flgwgkmfnf prldllknif fkdetlalss nelrdilerq 241 nnqaitifpe vnimslelsi iqrklhqdfp fvinfynlly prfknfttlm aafssiknik 301 rkknrnniik earylfhrel dklvhksmkm esskvsdktt ppmivdnsyl ltkkeeissg 361 kpkvvrinpy iydvtiiyyr vkytdsghdh tngdlrlhkg yqleqispti femiqpemes 421 ennikdkdpi vvmvnvkkhq iqpllaynde slekwlenrw iekdrliesl qknikietk // LOCUS NP_014942 151 aa linear PLN 30-JUN-2025 DEFINITION multiprotein-bridging factor 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014942 VERSION NP_014942.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184346.3 REFERENCE 1 (residues 1 to 151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 151) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11064. On Jul 30, 2012 this sequence version replaced NP_014942.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..151 /product="multiprotein-bridging factor 1" /calculated_mol_wt="16272" Region 3..75 /region_name="MBF1" /note="Multiprotein bridging factor 1; pfam08523" /db_xref="CDD:462508" Region 74..136 /region_name="aMBF1" /note="Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]; COG1813" /db_xref="CDD:441418" CDS 1..151 /gene="MBF1" /locus_tag="YOR298C-A" /gene_synonym="SUF13" /coded_by="NM_001184346.3:1..456" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:39566505]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:39566505]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:39566505]" /experiment="EXISTENCE:genetic interaction:GO:0140469 GCN2-mediated signaling [PMID:39566505]" /experiment="EXISTENCE:mutant phenotype:GO:0140469 GCN2-mediated signaling [PMID:39566505]" /note="Core integrated stress response (ISR) factor; optimizes ribosome collision-mediated Gcn2 activation and the downstream Gcn4-mediated transcriptional response; required for optimal stress-induced eIF2alpha (Sui2p) phosphorylation and downstream de-repression of GCN4 translation; Mbf1p is recruited to collided disomes and trisomes during the ISR; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress; homologous to human EDF1" /db_xref="GeneID:854474" /db_xref="SGD:S000007253" ORIGIN 1 msdwdtntii gsraraggsg pranvarsqg qinaarrqgl vvsvdkkygs tntrgdnegq 61 rltkvdretd ivkpkkldpn vgraisrart dkkmsqkdla tkinekptvv ndyeaaraip 121 nqqvlskler algvklrgnn igsplgapkk k // LOCUS NP_014943 746 aa linear PLN 30-JUN-2025 DEFINITION exomer complex subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_014943 VERSION NP_014943.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183718.1 REFERENCE 1 (residues 1 to 746) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 746) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 746) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 746) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 746) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11065. Method: conceptual translation. FEATURES Location/Qualifiers source 1..746 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..746 /product="exomer complex subunit" /calculated_mol_wt="84699" Region 123..533 /region_name="ChAPs" /note="ChAPs (Chs5p-Arf1p-binding proteins); pfam09295" /db_xref="CDD:401292" Region 371..400 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..746 /gene="BUD7" /locus_tag="YOR299W" /coded_by="NM_001183718.1:1..2241" /experiment="EXISTENCE:direct assay:GO:0030140 trans-Golgi network transport vesicle [PMID:16498409]" /experiment="EXISTENCE:direct assay:GO:0034044 exomer complex [PMID:17000877]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:16498409]" /experiment="EXISTENCE:mutant phenotype:GO:0000282 cellular bud site selection [PMID:8657162]" /experiment="EXISTENCE:physical interaction:GO:0006031 chitin biosynthetic process [PMID:16498409]" /note="Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication" /db_xref="GeneID:854475" /db_xref="SGD:S000005825" ORIGIN 1 mitqnsipev kedfigyalh errirlpqfq dlgpadlvtl tkylptssnt nainstsrng 61 aaiiqspaav vaddsaasma tngdasdtav ttnytnasiy sssrnandga pmvaelhpld 121 klkdevgtff ysmgvdtsgp tsiaiflkei sevisekpqv wfgrkktfnv arisfstwna 181 frrcdinvvv hipgsiqnfi vdcngesqni emcadydliw aetfvsgvvr simlmkenae 241 egelqnlvet lilnpftagq iddvpemfid lfpivyhkgp llgapyyitn vtntnnylve 301 tlveivkltr nvsraeimlk nlatdnpeai iilikiflvc dqeldaiklt ydmlsqdkii 361 nntnnrmdyk sellclqaqf lidkrqdysl aqniaqeavn cspsefrpwy llskvyvkln 421 dienalliln scpmsplkek yvlkrvaplp snnslhlplp idvvldevts lnpqdvqneh 481 rsadpmlvnl aasnlkstfq layrllteiv qitgwenllk yrsnifvmee eyqksssslp 541 kdvnkqeeqp lrakrlcerw ldnlfmllye dlkmytlwqt eqlymdaqnn nhnkltfewe 601 lfglcarrlg hfpeaakafq nglsqrfssr carklleyci nerqrvknfi nspnshdmvp 661 eivssrirel dnsiidlcvk iccwnhrwyt efsislldcl svviqdmslt kvsneissry 721 petvlnlvqe nllnffttct igcyda // LOCUS NP_014945 435 aa linear PLN 30-JUN-2025 DEFINITION Rax1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014945 VERSION NP_014945.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183720.3 REFERENCE 1 (residues 1 to 435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 435) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11066. On Jul 30, 2012 this sequence version replaced NP_014945.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..435 /product="Rax1p" /calculated_mol_wt="50030" Region <189..255 /region_name="RGS" /note="Regulator of G protein signalling domain; smart00315" /db_xref="CDD:214613" CDS 1..435 /gene="RAX1" /locus_tag="YOR301W" /coded_by="NM_001183720.3:1..1308" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005621 cellular bud scar [PMID:15356260|PMID:25416945]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14980713|PMID:15356260]" /experiment="EXISTENCE:genetic interaction:GO:0007121 bipolar cellular bud site selection [PMID:14980713]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:29074565]" /experiment="EXISTENCE:mutant phenotype:GO:0007121 bipolar cellular bud site selection [PMID:14980713]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:25416945]" /note="Protein involved in establishing bud site selection; localizes to the bud neck and previous sites of cell division (bud scars or cytokinesis remnants (CRMs); localization to both sites is interdependent with Rax2p; required with Rax2p to anchor Nba1p and Nis1p to CRMs where a Cdc42p inhibitory zone is established, preventing repolarization of cells at previous division sites; predicted type IIIa transmembrane protein with similarity to members of the insulin-related peptide superfamily" /db_xref="GeneID:854477" /db_xref="SGD:S000005827" ORIGIN 1 mkeelskvss mqnfemiqre rlptlyevli qrtsqpvdlw tfytflsqfp yainyldfwv 61 dlmthtrlck nyielvrksl infpqeqqqn gststatfdl lnalieeghl dpeapdklle 121 nsgpdvpfsp klnellgdwk hqsgigqeal rnedvalivd eimkrrsqqd gkpqittkql 181 lhsavglcnt ylvspeqser ylsnipmetr nriiesvqie rkydieifdd lknltyqfle 241 mdcfpkflsr valhnihdei sdwrfhsvgv tneksnrsrg qthisrspfs nhtsisrigf 301 gllwlgigfw igyvliflay srairvvtvv pftlgcyciv cgmyqvdivy swfgvtqrll 361 hrhknagnde gdassdtdhv pmilavfggr rrltriehpf trqllrkrgl wclllvvgat 421 aaftvifscv pgrrv // LOCUS NP_014946 25 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR302W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014946 VERSION NP_014946.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183721.1 REFERENCE 1 (residues 1 to 25) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 25) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 25) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 25) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 25) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11067. Method: conceptual translation. FEATURES Location/Qualifiers source 1..25 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..25 /product="uncharacterized protein" /calculated_mol_wt="2848" Region 2..24 /region_name="Leader_CPA1" /note="arg-2/CPA1 leader peptide; pfam08252" /db_xref="CDD:285459" CDS 1..25 /locus_tag="YOR302W" /coded_by="NM_001183721.1:1..78" /experiment="EXISTENCE:curator inference:GO:0005829 cytosol [PMID:10608810]" /experiment="EXISTENCE:direct assay:GO:0006417 regulation of translation [PMID:10608810]" /note="CPA1 uORF; Arginine attenuator peptide, regulates translation of the CPA1 mRNA" /db_xref="GeneID:854478" /db_xref="SGD:S000005828" ORIGIN 1 mfslsnsqyt cqdyisdhiw ktssh // LOCUS NP_014947 411 aa linear PLN 30-JUN-2025 DEFINITION carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014947 VERSION NP_014947.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183722.3 REFERENCE 1 (residues 1 to 411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 411) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11068. On Jul 30, 2012 this sequence version replaced NP_014947.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..411 /product="carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA1" /EC_number="6.3.5.5" /calculated_mol_wt="45231" Region 8..372 /region_name="CPSaseIIsmall" /note="carbamoyl-phosphate synthase, small subunit; TIGR01368" /db_xref="CDD:273580" CDS 1..411 /gene="CPA1" /locus_tag="YOR303W" /coded_by="NM_001183722.3:1..1236" /experiment="EXISTENCE:direct assay:GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [PMID:8626695]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005951 carbamoyl-phosphate synthase complex [PMID:206535]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:mutant phenotype:GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [PMID:6086650]" /experiment="EXISTENCE:mutant phenotype:GO:0006526 L-arginine biosynthetic process [PMID:9290206]" /note="Small subunit of carbamoyl phosphate synthetase; carbamoyl phosphate synthetase catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader" /db_xref="GeneID:854479" /db_xref="SGD:S000005829" ORIGIN 1 mssaatkatf ciqngpsfeg isfganksva getvfttslv gypesmtdps yrgqilvftq 61 plignygvps geardeynll kyfesphihv vgivvaeyay qyshwtaves laqwcqregv 121 aaitgvdtre lvqylreqgs slgritladh dpvpyvnpmk tnlvaqvttk kpfhvsalpg 181 kakanvalid cgvkeniirc lvkrganvtv fpydyriqdv asefdgifls ngpgnpelcq 241 atisnvrell nnpvydcipi fgiclghqll alasgasthk lkygnrahni pamdlttgqc 301 hitsqnhgya vdpetlpkdq wkpyfvnlnd ksnegmihlq rpifstqfhp eakggpldta 361 ilfdkffdni ekyqlqsqak ssislkvtys tdksrlqsin vtklakervl f // LOCUS NP_014948 1120 aa linear PLN 30-JUN-2025 DEFINITION DNA translocase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014948 VERSION NP_014948.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183724.1 REFERENCE 1 (residues 1 to 1120) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1120) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1120) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1120) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1120) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11069. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1120 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1120 /product="DNA translocase" /calculated_mol_wt="130197" Region 1..1093 /region_name="PLN03142" /note="Probable chromatin-remodeling complex ATPase chain; Provisional" /db_xref="CDD:215601" CDS 1..1120 /gene="ISW2" /locus_tag="YOR304W" /coded_by="NM_001183724.1:1..3363" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16227570]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:19203228]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005880 nuclear microtubule [PMID:10620773]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:16227570]" /experiment="EXISTENCE:direct assay:GO:0008623 CHRAC [PMID:14673157]" /experiment="EXISTENCE:direct assay:GO:0015616 DNA translocase activity [PMID:19203228]" /experiment="EXISTENCE:direct assay:GO:0019237 centromeric DNA binding [PMID:23468649]" /experiment="EXISTENCE:genetic interaction:GO:0006369 termination of RNA polymerase II transcription [PMID:12504018]" /experiment="EXISTENCE:genetic interaction:GO:0060195 negative regulation of antisense RNA transcription [PMID:18075583]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12624196]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:17689493]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:16227570|PMID:11238381]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:14673157]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:12624196]" /note="ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth; exhibits basal levels of chromatin binding throughout the genome as well as interacts with sequence-specific factors to accurately position nucleosomes in chromatin; targeted by Ume6p- and Sua7p-dependent DNA looping to many loci genome-wide" /db_xref="GeneID:854480" /db_xref="SGD:S000005831" ORIGIN 1 mttqqeeqrs dtknsksesp sevlvdtlds ksngssdddn igqseelsdk eiytvedrpp 61 eywaqrkkkf vldvdpkyak qkdksdtykr fkyllgvtdl frhfigikak hdkniqkllk 121 qldsdankls kshstvssss rhhrktekee daelmadeee eivdtyqedi fvsespsfvk 181 sgklrdyqvq glnwlislhe nklsgilade mglgktlqti sflgylryvk qiegpfliiv 241 pkstldnwrr eflkwtpnvn vlvlhgdkdt radivrniil earfdvlits yemvirekna 301 lkrlawqyiv ideahrikne qsalsqiirl fysknrllit gtplqnnlhe lwallnfllp 361 difgdselfd ewfeqnnseq dqeiviqqlh svlnpfllrr vkadveksll pkietnvyvg 421 mtdmqiqwyk sllekdidav ngavgkregk trllnivmql rkccnhpylf egaepgppyt 481 tdehlifnsg kmiildkllk rlkekgsrvl ifsqmsrlld iledycyfrd feycridgst 541 sheerieaid eynkpnsekf vfllttragg lginlvtadt vilfdsdwnp qadlqamdra 601 hrigqkkqvh vyrfvtenai eekvieraaq klrldqlviq qgtgkktasl gnskddlldm 661 iqfgaknmfe kkaskvtvda diddilkkge qktqelnaky qslglddlqk fngienqsay 721 ewngksfqkk sndkvvewin psrrerrreq ttysvddyyk eiigggsksa skqtpqpkap 781 rapkvihgqd fqffpkelda lqekeqlyfk kkvnykvtsy ditgdirneg sdaeeeegey 841 knaanteghk gheelkrrie eeqekinsap dftqedelrk qeliskaftn wnkrdfmafi 901 nacakygrdd menikksids ktpeevevya kifwerlkei ngwekylhnv elgekknekl 961 kfqetllrqk ieqckhplhe liiqyppnna rrtyntledk flllavnkyg lradklyekl 1021 kqeimmsdlf tfdwfiktrt vhelskrvht lltlivreye qpdankkkrs rtsatredtp 1081 lsqnestras tvpnlpttmv tnqkdtndhv dkrtkidqea // LOCUS NP_014949 76 aa linear PLN 30-JUN-2025 DEFINITION Bil1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014949 VERSION NP_014949.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183723.3 REFERENCE 1 (residues 1 to 76) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 76) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 76) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 76) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 76) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11070. On Jul 30, 2012 this sequence version replaced NP_014949.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..76 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..76 /product="Bil1p" /calculated_mol_wt="8486" CDS 1..76 /gene="BIL1" /locus_tag="YOR304C-A" /coded_by="NM_001183723.3:1..231" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:23671312]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:23671312|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051017 actin filament bundle assembly [PMID:23671312]" /note="Protein that binds Bud6p and has a role in actin cable assembly; involved in the Bnr1p-dependent pathway of cable assembly; localizes to bud tip and bud neck" /db_xref="GeneID:854481" /db_xref="SGD:S000005830" ORIGIN 1 msteklease epqaplants etnsikgdte nivtvfdlan eiekslkdvq rqmkenddef 61 srsiqaiedk lnkmsr // LOCUS NP_014950 242 aa linear PLN 30-JUN-2025 DEFINITION Rrg7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014950 VERSION NP_014950.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183725.1 REFERENCE 1 (residues 1 to 242) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 242) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 242) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 242) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11071. Method: conceptual translation. FEATURES Location/Qualifiers source 1..242 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..242 /product="Rrg7p" /calculated_mol_wt="27835" Region 29..219 /region_name="DUF2034" /note="Protein of unknown function (DUF2034); pfam10356" /db_xref="CDD:287343" CDS 1..242 /gene="RRG7" /locus_tag="YOR305W" /coded_by="NM_001183725.1:1..729" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene" /db_xref="GeneID:854482" /db_xref="SGD:S000005832" ORIGIN 1 miknylgrrw lnnpaiqayv kqnaavahst vfqgnlyeyt vmrelseklr mtklrktgga 61 hdggvdikgs wpvddiywki sslmpnlema snikrtnsqn gfvlkplkyr iidhtfeplk 121 vlvqckaftk sklsprefre lvgtftslvs hsqrnktvci mcsphmltkd tlnlinnitl 181 pliylrveml kektdghfdl insgklinyy ensyastlmq dckisewlkl klyknsdfns 241 ek // LOCUS NP_014951 521 aa linear PLN 30-JUN-2025 DEFINITION riboflavin transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_014951 VERSION NP_014951.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183726.4 REFERENCE 1 (residues 1 to 521) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 521) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 521) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 521) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 521) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11072. On Jul 30, 2012 this sequence version replaced NP_014951.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..521 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..521 /product="riboflavin transporter" /calculated_mol_wt="57451" Region 106..510 /region_name="MFS_MCT_SLC16" /note="Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; cd17352" /db_xref="CDD:340910" Site order(117..118,121..122,125,162,213..214,216..218,221,240, 243..244,247,339,342..343,346..348,351,378,382,433..434, 438,442,458,461..462,465..466,469) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340910" CDS 1..521 /gene="MCH5" /locus_tag="YOR306C" /coded_by="NM_001183726.4:1..1566" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16204239]" /experiment="EXISTENCE:genetic interaction:GO:0032217 riboflavin transmembrane transporter activity [PMID:16204239]" /experiment="EXISTENCE:genetic interaction:GO:0032218 riboflavin transport [PMID:16204239]" /note="Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport" /db_xref="GeneID:854483" /db_xref="SGD:S000005833" ORIGIN 1 mssdsltpkd tivpeeqtnq lrqpdldeds ihydpeaddl eslettasya stsvsakvyt 61 kkevnkgtdi esqphwgent ssthdsdkee dsneeiesfp eggfkawvvt fgcflgliac 121 fgllnstgvi eshlqdnqls sesvstigwl fslflfvcsa sciisgtyfd rngfrtimiv 181 gtvfhvaglf atanstkywh filsfaivcg fgngivlspl vsvpahyffk rrgtalamat 241 iggsvggvvf pimlrsffsm ksdtdptygf vwgirtlgfl dlalltlsii lvkerlphvi 301 enskdgesrw ryilrvyilq cfdakafldm kylfcvlgtv fselsinsal tyygsyatsh 361 gisandaytl imiinvcgip grwvpgylsd kfgrfnvaia tlltlfivmf vgwlpfgtnl 421 tnmyvisaly gfcsgsvfsl lpvccgqisk teefgkryst myfvvgfgtl vgipitgaii 481 sikttadyqh yiifcglatf vsavcyiisr aycvgfkwvr f // LOCUS NP_014952 453 aa linear PLN 30-JUN-2025 DEFINITION Sly41p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014952 VERSION NP_014952.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183727.1 REFERENCE 1 (residues 1 to 453) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 453) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 453) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 453) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 453) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11073. Method: conceptual translation. FEATURES Location/Qualifiers source 1..453 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..453 /product="Sly41p" /calculated_mol_wt="50772" Region 112..451 /region_name="tpt" /note="Tpt phosphate/phosphoenolpyruvate translocator; TIGR00817" /db_xref="CDD:129898" CDS 1..453 /gene="SLY41" /locus_tag="YOR307C" /coded_by="NM_001183727.1:1..1362" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:23613772|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:1903839]" /note="Protein involved in ER-to-Golgi transport; packaged into COPII vesicles for trafficking between ER and Golgi" /db_xref="GeneID:854484" /db_xref="SGD:S000005834" ORIGIN 1 miqtqstaik rrnsvhknlf dpslyqipep prggfqhqkk eysketfsnq vfgyditslk 61 krftqlfpsn iqgylpevdl ritiicsiwy vtssissnls kailrtfnhp ialtelqflv 121 savlcvgfas ivnlfrlprl khtkfskaln sfpdgilpey ldgnfrssil hkflvpsklv 181 lmttfpmgif qfighitshk avsmipvslv hsvkalspii tvgyykffeh ryynsmtyyt 241 llllifgvmt tcwsthgskr asdnksgssl igllfafism iifvaqnifa kniltirrkv 301 gilpssstdd vtskegqpsl dktrfsplqv dkitilfycs cigfsltllp fltgelmhgg 361 svindltlet valvaihgia hffqamlafq ligllssiny svanimkriv visvalfwet 421 klnffqvfgv iltiaglygy dkwglskkdg rqa // LOCUS NP_014953 587 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit SNU66 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014953 VERSION NP_014953.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183728.3 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11074. On Jul 30, 2012 this sequence version replaced NP_014953.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..587 /product="U4/U6-U5 snRNP complex subunit SNU66" /calculated_mol_wt="66299" Region 5..26 /region_name="HIND" /note="HIND motif; pfam19252" /db_xref="CDD:466011" Region 36..56 /region_name="HIND" /note="HIND motif; pfam19252" /db_xref="CDD:466011" Region 75..570 /region_name="SART-1" /note="SART-1 family; pfam03343" /db_xref="CDD:460888" CDS 1..587 /gene="SNU66" /locus_tag="YOR308C" /coded_by="NM_001183728.3:1..1764" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10377396|PMID:10449419]" /experiment="EXISTENCE:genetic interaction:GO:0000481 maturation of 5S rRNA [PMID:19806183]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10449419|PMID:11720284]" /experiment="EXISTENCE:mutant phenotype:GO:0000481 maturation of 5S rRNA [PMID:19806183]" /note="Component of the U4/U6.U5 snRNP complex; involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1" /db_xref="GeneID:854485" /db_xref="SGD:S000005835" ORIGIN 1 mnktenlsie etneireklg mkpipvfqek ntdhkeslsi eetnelrasl glklippqqn 61 fnssppnvhn tskidelrek itkfqkkana plrmahllee tnvnddsswl enmdaipssh 121 eskrsstlpr kgatkedeni dlhnvqvsyn iealspkkdt iltlkessif ddtdstevle 181 nvkaaeenad reklrlrqmn kdrrqkkkil nvssldieee eegekhsitt thliigaeqg 241 vmkapntisa kpptgkvkvn fdsannmsde dggdfkplki kkrkikdprs tkarkskitd 301 kmeivklvde deslswmeee qpvtiinprt ssnnelkgpe dlareiekar deekrrtesi 361 lkmreisnsi vvdekvtfln tldtslsers atenkvkvhg egeknigdvt nghtkegsgn 421 ntlteavnne pnyegdaena pnffsglast lgylrkksvf ttgdvdlkpg kdvnnseslr 481 rdvrnkehtg tgtytkdklh gleqftssds snanthskrq dhydpdiklv yrdekgnrlt 541 tkeaykklsq kfhgtksnkk krakmksrie arkntpengs lfefddn // LOCUS NP_014955 511 aa linear PLN 30-JUN-2025 DEFINITION RNA-processing protein NOP58 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014955 VERSION NP_014955.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183730.1 REFERENCE 1 (residues 1 to 511) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 511) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 511) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 511) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11075. Method: conceptual translation. FEATURES Location/Qualifiers source 1..511 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..511 /product="RNA-processing protein NOP58" /calculated_mol_wt="56825" Region 3..66 /region_name="NOP5NT" /note="NOP5NT (NUC127) domain; pfam08156" /db_xref="CDD:462382" Region 170..398 /region_name="Nop" /note="snoRNA binding domain, fibrillarin; pfam01798" /db_xref="CDD:460335" CDS 1..511 /gene="NOP58" /locus_tag="YOR310C" /gene_synonym="NOP5" /coded_by="NM_001183730.1:1..1536" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:9372940]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10094313|PMID:11081632]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10094313]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10094313]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:10094313]" /experiment="EXISTENCE:physical interaction:GO:0031428 box C/D methylation guide snoRNP complex [PMID:10733567]" /note="Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA" /db_xref="GeneID:854487" /db_xref="SGD:S000005837" ORIGIN 1 mayvltetsa gyallkasdk kiyksssliq dldssdkvlk efkiaafskf nsaanaleea 61 nsiiegkvss qleklleeik kdkkstlivs etklanaink lglnfnvvsd avtldiyrai 121 keylpellpg msdndlskms lglahsigrh klkfsadkvd vmiiqaiall ddldkelnty 181 amrckewygw hfpelakivt dsvayariil tmgirskase tdlseilpee ieervktaae 241 vsmgteitqt dldninalae qivefaayre qlsnylsarm kaiapnltql vgelvgarli 301 ahsgslisla kspastiqil gaekalfral ktkhdtpkyg llyhaslvgq atgknkgkia 361 rvlaakaavs lrydalaedr ddsgdigles rakvenrlsq legrdlrttp kvvreakkve 421 mtearaynad adtakaasds esdsddeeee kkekkekkrk rdddedskds kkakkekkdk 481 kekkekkekk ekkekkekke kkskkekkek k // LOCUS NP_014956 290 aa linear PLN 30-JUN-2025 DEFINITION diacylglycerol kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014956 VERSION NP_014956.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183731.3 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11076. On Jul 30, 2012 this sequence version replaced NP_014956.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..290 /product="diacylglycerol kinase" /EC_number="2.7.1.174" /calculated_mol_wt="32709" Region 71..281 /region_name="SEC59" /note="Dolichol kinase [Posttranslational modification, protein turnover, chaperones, Cell wall/membrane/envelope biogenesis]; COG0170" /db_xref="CDD:439940" CDS 1..290 /gene="DGK1" /locus_tag="YOR311C" /gene_synonym="HSD1" /coded_by="NM_001183731.3:1..873" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11481671]" /experiment="EXISTENCE:direct assay:GO:0006654 phosphatidic acid biosynthetic process [PMID:18458076]" /experiment="EXISTENCE:direct assay:GO:0141035 CTP-dependent diacylglycerol kinase activity [PMID:18458076|PMID:18458075]" /experiment="EXISTENCE:mutant phenotype:GO:0006654 phosphatidic acid biosynthetic process [PMID:18458075]" /experiment="EXISTENCE:mutant phenotype:GO:2001210 regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway [PMID:32058036]" /note="Diacylglycerol kinase; localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures, stimulates the mevalonate/ergosterol pathway and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain" /db_xref="GeneID:854488" /db_xref="SGD:S000005838" ORIGIN 1 mgtedaialp nstleprtea kqrlsskshq vsakvtipak eeisssddda hvpvteihlk 61 shewfgdfit kheiprkvfh ssigfitlyl ytqginyknv lwpliyafii lfildlirln 121 wpffnmlycr tvgalmrkke ihtyngvlwy ilglifsfnf fskdvtlisl fllswsdtaa 181 atigrkyghl tpkvarnksl agsiaaftvg vitcwvfygy fvpaysyvnk pgeiqwspet 241 srlslnmlsl lggvvaalse gidlfnwddn ftipvlsslf mnaviktfkk // LOCUS NP_014957 172 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL20 RPL20B [Saccharomyces cerevisiae S288C]. ACCESSION NP_014957 VERSION NP_014957.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183732.1 REFERENCE 1 (residues 1 to 172) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 172) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 172) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 172) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11077. On Jul 30, 2007 this sequence version replaced NP_014957.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..172 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..172 /product="60S ribosomal protein eL20 RPL20B" /calculated_mol_wt="20306" Region 80..127 /region_name="Ribosomal_L18A" /note="Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A; pfam01775" /db_xref="CDD:396369" CDS 1..172 /gene="RPL20B" /locus_tag="YOR312C" /gene_synonym="RPL18A1" /coded_by="NM_001183732.1:1..519" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:23874617]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:23874617]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:23874617]" /note="Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication" /db_xref="GeneID:854489" /db_xref="SGD:S000005839" ORIGIN 1 mahfkeyqvi grrlptesvp epklfrmrif asneviaksr ywyflqklhk vkkasgeivs 61 inqineahpt kvknfgvwvr ydsrsgthnm ykeirdvsrv aavetlyqdm aarhrarfrs 121 ihilkvaeie ktadvkrqyv kqfltkdlkf plphrvqkst ktfsykrpst fy // LOCUS NP_014958 338 aa linear PLN 30-JUN-2025 DEFINITION Sps4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014958 VERSION NP_014958.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183733.3 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11078. On Jul 30, 2012 this sequence version replaced NP_014958.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..338 /product="Sps4p" /calculated_mol_wt="38460" Region 65..317 /region_name="Perilipin_2" /note="Perilipin protein; pfam17316" /db_xref="CDD:465405" CDS 1..338 /gene="SPS4" /locus_tag="YOR313C" /coded_by="NM_001183733.3:1..1017" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24390141]" /experiment="EXISTENCE:expression pattern:GO:0030437 ascospore formation [PMID:3540611]" /note="Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage" /db_xref="GeneID:854490" /db_xref="SGD:S000005840" ORIGIN 1 mpsnlnivkv tkpqeenknf lhkntnepne meqsqtqeav tenftensnl sanehaarrg 61 rlnlktvdhi etypivqete eiakkialtr iilaqtkpri dkvvvsrpvq avapvvnffd 121 kmanstlstv ervvpslktk tykrlgeeia lpytlskkyg kqlrdttarn gdnyvyqpvh 181 grlmkfrkyy nekfidtkgk plirgqldpv llpvnntfek vtvkylpkgk kvpndsfsce 241 fnrglaleyn fmtravsavs hqvvgiaklp iaygyhtnsv ynknldkqad lkmknvlrgt 301 wdtitdlere iwasvtdrsl frffgnkseg gdlphlvq // LOCUS NP_014960 346 aa linear PLN 30-JUN-2025 DEFINITION Sfg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014960 VERSION NP_014960.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183735.1 REFERENCE 1 (residues 1 to 346) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 346) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 346) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 346) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 346) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11079. Method: conceptual translation. FEATURES Location/Qualifiers source 1..346 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..346 /product="Sfg1p" /calculated_mol_wt="38890" CDS 1..346 /gene="SFG1" /locus_tag="YOR315W" /coded_by="NM_001183735.1:1..1041" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16289536|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:16289536]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:19033152]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:16289536]" /experiment="EXISTENCE:mutant phenotype:GO:0036267 invasive filamentous growth [PMID:32665277]" /experiment="EXISTENCE:mutant phenotype:GO:0090033 positive regulation of filamentous growth [PMID:32665277]" /experiment="EXISTENCE:mutant phenotype:GO:0098609 cell-cell adhesion [PMID:32665277]" /note="Putative transcription factor; induces superficial pseudohyphal growth, positively regulates invasive growth, but is not required for invasive pseudohyphal growth; may act together with Phd1p; promotes cell adhesion independent of Flo11p by repressing genes that encode cell wall degrading enzymes; localizes to the nucleus; potential Cdc28p substrate" /db_xref="GeneID:854493" /db_xref="SGD:S000005842" ORIGIN 1 mdemhssdtl llrtpkskkk iglvipstps kkckyssgfi aedttpskrf rlyqakfkts 61 sknvkaqtls vsikknqgei tnpfmtegyn dyrnivspgl sfdndcfseh elvsplsdis 121 sinstspdve kidsldpfgv dsfvwnckpl vnkealelhr mihssfpmsp lesnsdvpll 181 lpklkkrlsp vnrstfkptr yepshrllkp kksiltvpak slnlivsssr gslndatifa 241 teinstlsne enklpaissi wekltipvns sikekykklk dqiygqasnf gededneedn 301 eddlpdaavi rgyefqsgrr deltqcnelq stkdykkvqw akvleq // LOCUS NP_014961 439 aa linear PLN 30-JUN-2025 DEFINITION metal cation transporter COT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014961 VERSION NP_014961.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183736.3 REFERENCE 1 (residues 1 to 439) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 439) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 439) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 439) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 439) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11080. On Jul 30, 2012 this sequence version replaced NP_014961.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..439 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..439 /product="metal cation transporter COT1" /calculated_mol_wt="48024" Region 14..381 /region_name="CzcD" /note="Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; COG1230" /db_xref="CDD:440843" CDS 1..439 /gene="COT1" /locus_tag="YOR316C" /coded_by="NM_001183736.3:1..1320" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:9712830]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:26928762|PMID:27881666]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /experiment="EXISTENCE:genetic interaction:GO:0005385 zinc ion transmembrane transporter activity [PMID:8058041]" /experiment="EXISTENCE:genetic interaction:GO:0006829 zinc ion transport [PMID:8058041]" /experiment="EXISTENCE:mutant phenotype:GO:0006824 cobalt ion transport [PMID:1508175]" /experiment="EXISTENCE:mutant phenotype:GO:0006882 intracellular zinc ion homeostasis [PMID:10856230]" /experiment="EXISTENCE:mutant phenotype:GO:0015087 cobalt ion transmembrane transporter activity [PMID:1508175]" /note="Vacuolar transporter that mediates zinc transport into vacuole; overexpression confers resistance to cobalt and rhodium; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress; COT1 has a paralog, ZRC1, that arose from the whole genome duplication" /db_xref="GeneID:854494" /db_xref="SGD:S000005843" ORIGIN 1 mklgskqvki islllldtvf fgieittgyl shslaliads fhmlndiisl vvalwavnva 61 knrnpdstyt ygwkraeilg alinavflia lcvsilieal qriiappvie npkfvlyvgv 121 aglisntvgl flfhdndqeh ghghghshgg ifadhemhmp sshththahv dgienttpmd 181 stdniseimp naivdsfmne ntrlltpena sktpsystss htiasggnyt ehnkrkrsln 241 mhgvflhvlg dalgnigvml saffiwktdy swkyytdplv sliitgiifs salplsckas 301 killqatpst lsgdqvegdl lkipgiiaih dfhiwnltes ifiaslhiql dispeqftdl 361 akivrsklhr ygihsatlqp efitrevtst eragdsqgdh lqndplslrp ktygtgisgs 421 tcliddaanc ntadcledh // LOCUS NP_878175 69 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR316C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878175 VERSION NP_878175.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184577.1 REFERENCE 1 (residues 1 to 69) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 69) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 69) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 69) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 69) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11081. Method: conceptual translation. FEATURES Location/Qualifiers source 1..69 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..69 /product="uncharacterized protein" /calculated_mol_wt="7701" CDS 1..69 /locus_tag="YOR316C-A" /coded_by="NM_001184577.1:1..210" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466487" /db_xref="SGD:S000028584" ORIGIN 1 mlvpmhnspt aangrlsltv assglrkgkk nrvytihsyi rspvsssefs fsvrrqyklt 61 irikqkthl // LOCUS NP_014962 700 aa linear PLN 30-JUN-2025 DEFINITION long-chain fatty acid-CoA ligase FAA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014962 VERSION NP_014962.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183737.3 REFERENCE 1 (residues 1 to 700) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 700) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 700) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 700) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 700) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11082. On Jul 30, 2012 this sequence version replaced NP_014962.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..700 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..700 /product="long-chain fatty acid-CoA ligase FAA1" /EC_number="6.2.1.3" /calculated_mol_wt="77736" Region 95..685 /region_name="LC_FACS_euk1" /note="Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; cd17639" /db_xref="CDD:341294" Region <217..>281 /region_name="Adenylate forming domain, Class I superfamily" /note="This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate...; cl17068" /db_xref="CDD:473059" Site order(267,270..275,277..278) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341294" Site order(267,270..275,277..278) /site_type="other" /note="acyl-activating enzyme (AAE) consensus motif" /db_xref="CDD:341228" Site order(270,393..394,454..459,538,550,553,565,677) /site_type="other" /note="putative AMP binding site [chemical binding]" /db_xref="CDD:341294" Site order(270,312..313,364,366..367,370,393..394,454..459,538, 550,553,562..565,654) /site_type="active" /note="putative active site [active]" /db_xref="CDD:341294" Site order(312,366..367,370,393,562..564,652,654) /site_type="other" /note="putative CoA binding site [chemical binding]" /db_xref="CDD:341294" CDS 1..700 /gene="FAA1" /locus_tag="YOR317W" /coded_by="NM_001183737.3:1..2103" /experiment="EXISTENCE:direct assay:GO:0004467 long-chain fatty acid-CoA ligase activity [PMID:8206942]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:22842922|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093|PMID:10515935]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:27136724|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0031956 medium-chain fatty acid-CoA ligase activity [PMID:8206942]" /experiment="EXISTENCE:genetic interaction:GO:0004467 long-chain fatty acid-CoA ligase activity [PMID:22633490|PMID:11477098]" /experiment="EXISTENCE:genetic interaction:GO:0035336 long-chain fatty-acyl-CoA metabolic process [PMID:11477098]" /experiment="EXISTENCE:genetic interaction:GO:0044539 long-chain fatty acid import into cell [PMID:12601005|PMID:27136724]" /experiment="EXISTENCE:genetic interaction:GO:1905329 sphingoid long-chain base transport [PMID:27136724]" /experiment="EXISTENCE:mutant phenotype:GO:0004467 long-chain fatty acid-CoA ligase activity [PMID:11477098]" /experiment="EXISTENCE:mutant phenotype:GO:0035336 long-chain fatty-acyl-CoA metabolic process [PMID:11477098]" /experiment="EXISTENCE:mutant phenotype:GO:0044539 long-chain fatty acid import into cell [PMID:27136724|PMID:12601005]" /experiment="EXISTENCE:mutant phenotype:GO:1905329 sphingoid long-chain base transport [PMID:27136724]" /note="Long chain fatty acyl-CoA synthetase; activates fatty acids with a preference for C12:0-C16:0 chain lengths; role in the competitive import of long-chain fatty acids and sphingoid long-chain bases; accounts for most acyl-CoA synthetase activity; localizes to lipid particles and the plasma membrane; role in sphingolipid-to-glycerolipid metabolism; forms ER foci upon replication stress; faa1 faa4 double null complemented by any of human ACSBG1, ACSL1, 3, 4, 5, 6, SLC27A2, or 4" /db_xref="GeneID:854495" /db_xref="SGD:S000005844" ORIGIN 1 mvaqytvpvg kaanehetap rrnyqcrekp lvrppntkcs tvyefvlecf qknknsnamg 61 wrdvkeihee sksvmkkvdg ketsvekkwm yyelshyhyn sfdqltdimh eigrglvkig 121 lkpndddklh lyaatshkwm kmflgaqsqg ipvvtaydtl gekglihslv qtgskaiftd 181 nsllpslikp vqaaqdvkyi ihfdsissed rrqsgkiyqs ahdainrike vrpdiktfsf 241 ddilklgkes cneidvhppg kddlccimyt sgstgepkgv vlkhsnvvag vggaslnvlk 301 fvgntdrvic flplahifel vfellsfywg acigyatvkt ltsssvrncq gdlqefkpti 361 mvgvaavwet vrkgilnqid nlpfltkkif wtayntklnm qrlhipggga lgnlvfkkir 421 tatggqlryl lnggspisrd aqefitnlic pmligyglte tcasttildp anfelgvagd 481 ltgcvtvklv dveelgyfak nnqgevwitg anvtpeyykn eeetsqalts dgwfktgdig 541 eweanghlki idrkknlvkt mngeyialek lesvyrsney vanicvyadq sktkpvgiiv 601 pnhapltkla kklgimeqkd ssinienyle daklikavys dllktgkdqg lvgiellagi 661 vffdgewtpq ngfvtsaqkl krkdilnavk dkvdavysss // LOCUS NP_014964 213 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit HSH49 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014964 VERSION NP_014964.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183739.1 REFERENCE 1 (residues 1 to 213) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 213) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 213) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 213) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11083. Method: conceptual translation. FEATURES Location/Qualifiers source 1..213 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..213 /product="U2 snRNP complex subunit HSH49" /calculated_mol_wt="24372" Region 10..>208 /region_name="PABP-1234" /note="polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628" /db_xref="CDD:130689" Region 11..85 /region_name="RRM1_SF3B4" /note="RNA recognition motif 1 (RRM1) found in splicing factor 3B subunit 4 (SF3B4) and similar proteins; cd12334" /db_xref="CDD:409771" CDS 1..213 /gene="HSH49" /locus_tag="YOR319W" /coded_by="NM_001183739.1:1..642" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9436903]" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:16314500|PMID:15565172]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9436903]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16314500]" /note="U2-snRNP associated splicing factor; similar to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)" /db_xref="GeneID:854497" /db_xref="SGD:S000005846" ORIGIN 1 mnysadsgnt vyvgnidpri tkeqlyelfi qinpvlriky pkdkvlqayq gyafiefynq 61 gdaqyaikim nntvrlydrl ikvrqvtnst gttnlpsnis kdmilpiakl fiknladsid 121 sdqlvkifnk fgklirepei fylsngklkc ayvyfedfek adlaikslnn qlvannritv 181 dyafkengkg nakygddvdr llnkealkhn mlk // LOCUS NP_014965 491 aa linear PLN 30-JUN-2025 DEFINITION glucose N-acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014965 VERSION NP_014965.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183740.3 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11084. On Jul 30, 2012 this sequence version replaced NP_014965.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..491 /product="glucose N-acetyltransferase" /calculated_mol_wt="57447" Region 92..482 /region_name="GT8_GNT1" /note="GNT1 is a fungal enzyme that belongs to the GT 8 family; cd06914" /db_xref="CDD:133064" Site order(97..99,102..103,182,196,198..200,224,314..316, 346..347,390..391,435,437..438,443) /site_type="active" /note="putative ligand binding site [active]" /db_xref="CDD:133064" Site order(198,200,435) /site_type="active" /note="metal binding site [active]" /db_xref="CDD:133064" CDS 1..491 /gene="GNT1" /locus_tag="YOR320C" /coded_by="NM_001183740.3:1..1476" /experiment="EXISTENCE:direct assay:GO:0005797 Golgi medial cisterna [PMID:12651885]" /experiment="EXISTENCE:direct assay:GO:0008375 acetylglucosaminyltransferase activity [PMID:12651885]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:12651885]" /note="N-acetylglucosaminyltransferase; capable of modification of N-linked glycans in the Golgi apparatus" /db_xref="GeneID:854498" /db_xref="SGD:S000005847" ORIGIN 1 mrliskrrir fivfilfgvl tvfvvsrlvv hfqynqeikf ykkyfqqrkd glheiynple 61 ikqipketid dlytarldke lkngeviews kfayvnyvtn adylcntlii fndlkqefet 121 kaklvllisk dlldpntssn vayissllnk iqaidedqvv iklidnivkp kdttpwnesl 181 tkllvfnqte fdrviyldnd ailrssldel fflpnyikfa apltywflsn sdleksyhet 241 rhrekqpinl qsytkvltkr igkgqmiynh lpslphslyl nsnniaqdii sstsslsplf 301 dfqsskkvgk lkfasnlmvi npskeafdei vnvmlpkiln kkekydmdli neemynlkki 361 iykqfiffrk vrklfkpevl vlpfarygll tgslrnprhy siiyndvlgy ktldndgndi 421 pvglndsvay skyihfsdyp lakpwnypsm kefecivkee daedsklehq acdlwnsvya 481 syiqsreicl v // LOCUS NP_014966 753 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-phosphate-mannose-protein mannosyltransferase PMT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014966 VERSION NP_014966.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183741.1 REFERENCE 1 (residues 1 to 753) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 753) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 753) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 753) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 753) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11085. Method: conceptual translation. FEATURES Location/Qualifiers source 1..753 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..753 /product="dolichyl-phosphate-mannose-protein mannosyltransferase PMT3" /EC_number="2.4.1.109" /calculated_mol_wt="86192" Region 62..306 /region_name="PMT" /note="Dolichyl-phosphate-mannose-protein mannosyltransferase; pfam02366" /db_xref="CDD:396786" Region 332..525 /region_name="beta-trefoil_MIR_PMT2-like" /note="MIR domain, beta-trefoil fold, found in Saccharomyces cerevisiae dolichyl-phosphate-mannose--protein mannosyltransferase 2 (PMT2) and similar proteins; cd23284" /db_xref="CDD:467755" Site 398 /site_type="glycosylation" /note="glycosylation site [posttranslational modification]" /db_xref="CDD:467755" Site 499 /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:467755" Region 543..742 /region_name="PMT_4TMC" /note="C-terminal four TMM region of protein-O-mannosyltransferase; pfam16192" /db_xref="CDD:465056" CDS 1..753 /gene="PMT3" /locus_tag="YOR321W" /coded_by="NM_001183741.1:1..2262" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0097583 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex [PMID:12551906]" /experiment="EXISTENCE:direct assay:GO:0097585 dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex [PMID:12551906]" /experiment="EXISTENCE:genetic interaction:GO:0035269 protein O-linked mannosylation [PMID:9184828]" /note="Protein O-mannosyltransferase; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; antifungal drug target; PMT3 has a paralog, PMT2, that arose from the whole genome duplication" /db_xref="GeneID:854499" /db_xref="SGD:S000005848" ORIGIN 1 mpyrvatgys ekstdddliw rtpivkeele dadnflkdda elydkvknes avshldtivm 61 piiftvlgmf trmykigrnn hvvwdeahfg kfgsyylrhe fyhdvhpplg kmlvglsgyl 121 agyngswdfp sgevypdyid yvkmrlfqam fsslcvplay ftgraigfsr lsvwlftilv 181 ifensyatlg kfilldsmll fftvssyfcl akfhtmrksp fsarwwlwlc ltglnlgcai 241 svkmvglfii svvgiytise lwnllsdrsv swkvyvnhwl arifgliiip vcvfllcfki 301 hfdllsnsgp gdstmpslfq aslngtkvgk gprdvalgss iisiknqalg gallhshvqp 361 fpegseqqqv tvygysdann ewffqrirgv epwtdaenkt iefvkggemy rlmhrltgkn 421 lhthevpapi skseyevsay gdvdlgdykd nwiieiveqv geedptllhp lstsfrikns 481 ilgcylaqsg khlpewgfrq gevvclkhas krdkrtwwni ethenerlpq gedfvypkts 541 ffrnfmqlns ammatnnalv pnpekfdgia ssawqwptln vgvrlcewse ksikyfllgs 601 pasvwpssia vcaliihvif ltlkwqrqcv ilsdpverdv fvmaafypll awllhympfv 661 vmsrvvyahh ylptlyfalm ilsyyfdmit krwatrntgk flrlgayivy gsiviagffy 721 fspfsfgmdg pvddyaylaw lptwqivedi rnt // LOCUS NP_014967 818 aa linear PLN 30-JUN-2025 DEFINITION Ldb19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014967 VERSION NP_014967.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183742.3 REFERENCE 1 (residues 1 to 818) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 818) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 818) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 818) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 818) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11086. On Jul 30, 2012 this sequence version replaced NP_014967.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..818 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..818 /product="Ldb19p" /calculated_mol_wt="89695" Region 144..346 /region_name="LDB19" /note="Arrestin_N terminal like; pfam13002" /db_xref="CDD:404030" CDS 1..818 /gene="LDB19" /locus_tag="YOR322C" /gene_synonym="ART1" /coded_by="NM_001183742.3:1..2457" /experiment="EXISTENCE:direct assay:GO:0000138 Golgi trans cisterna [PMID:18976803]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18976803|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:22118465]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22118465|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:18976803|PMID:22118465]" /experiment="EXISTENCE:direct assay:GO:0031625 ubiquitin protein ligase binding [PMID:24820415]" /experiment="EXISTENCE:genetic interaction:GO:0002092 positive regulation of receptor internalization [PMID:24820415]" /experiment="EXISTENCE:mutant phenotype:GO:0002092 positive regulation of receptor internalization [PMID:24820415]" /experiment="EXISTENCE:mutant phenotype:GO:0031625 ubiquitin protein ligase binding [PMID:24820415]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:18976803]" /experiment="EXISTENCE:mutant phenotype:GO:0070086 ubiquitin-dependent endocytosis [PMID:18976803|PMID:32744498]" /experiment="EXISTENCE:mutant phenotype:GO:0071230 cellular response to amino acid stimulus [PMID:18976803]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]" /experiment="EXISTENCE:physical interaction:GO:0070086 ubiquitin-dependent endocytosis [PMID:18976803]" /note="Alpha-arrestin, Ub-ligase adaptor for Rsp5p; regulates starvation- and substrate-induced Ub-dependent endocytosis of select plasma membrane localized amino acid transporters, recruiting Rsp5p to its targets; role in basal internalization and turnover of Ste2p, mating and zygote formation; recruits Rsp5p to Ste2p via its 2 PPXY motifs; inhibited by Npr1p-mediated phosphorylation, affecting cytosol and plasma membrane translocation; localization regulated by Rsp5p-dependent ubiquitination" /db_xref="GeneID:854500" /db_xref="SGD:S000005849" ORIGIN 1 mafsrltsth qsnhngysns nkkgqslplt lsidvesppc vlygsamess gavlsglftv 61 tvvdpyssae dkslkntesn vsttskslkr kstfgsalss rlsslsasts nispstssts 121 ishsptpanl rimagytkit itsvtlslvq kihfhkpfvp nissmqtcmn cktkitnmks 181 weiqsntqdl svgshsypfs ylipgsvpcs sslgataetq vkyeliavvt yidphrnsfs 241 sghstprkeg ssskkrllql ampiavtrsi prgpdknslr vfppteltaa avlpnvvypk 301 stfplemkld gvssgdrrwr mrklswriee ttrvkahacp vhkhelrqle eqvkikesek 361 skkprshikr ygelgpqirv avnslenmps qrlpgepgre qapnssgpas tgnvgldden 421 pvnedeedqp gsefihpsdd alrqellmqq qrarqqqlqq elknnsslft eevriiskge 481 mksgwktdfd nngkielvte idcmglnsgv snpvmhastl qtpstgnkkp sinvacdiqd 541 pnlglyvshi laveivvaee tlqyangqpi rkpnsknkke tnnntmnvhn pdqrlaelsp 601 ifanrntpkv rrmgpeditp vnsnksnhst nkekasngas nsnivsvptg aarvlrmqfr 661 ltvtersglg iswdeevppi yqdvellspp cyelsinngi knklystmst pvrseddfvg 721 gsdedignye sqglepgpnv qevtitqnkl tipptahhyq passsqrslt tvqspplesv 781 vsvqgsvpfr ghvltphstr diriqnfsdf ldsnritq // LOCUS NP_014968 456 aa linear PLN 30-JUN-2025 DEFINITION glutamate-5-semialdehyde dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014968 VERSION NP_014968.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183743.1 REFERENCE 1 (residues 1 to 456) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 456) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 456) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 456) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11087. Method: conceptual translation. FEATURES Location/Qualifiers source 1..456 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..456 /product="glutamate-5-semialdehyde dehydrogenase" /EC_number="1.2.1.41" /calculated_mol_wt="49610" Region 11..422 /region_name="proA" /note="gamma-glutamyl phosphate reductase; TIGR00407" /db_xref="CDD:161862" Site 258 /site_type="active" /note="putative catalytic cysteine [active]" /db_xref="CDD:143398" CDS 1..456 /gene="PRO2" /locus_tag="YOR323C" /coded_by="NM_001183743.1:1..1371" /experiment="EXISTENCE:direct assay:GO:0004350 glutamate-5-semialdehyde dehydrogenase activity [PMID:12513997]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:25112878]" /experiment="EXISTENCE:direct assay:GO:0006561 proline biosynthetic process [PMID:12513997]" /note="Cytosolic gamma-glutamyl phosphate reductase; catalyzes the second step in proline biosynthesis" /db_xref="GeneID:854501" /db_xref="SGD:S000005850" ORIGIN 1 msssqqiakn arkagnilkt isnegrsdil ykihdalkan ahaieeanki dlavaketgl 61 adsllkrldl fkgdkfevml qgikdvaele dpvgkvkmar elddgltlyq vtapvgvllv 121 ifesrpevia nitalsiksg naailkggke svntfremak ivndtiaqfq setgvpvgsv 181 qlietrqdvs dlldqdeyid lvvprgsnal vrkikdttki pvlghadgic siyldedadl 241 ikakrislda ktnypagcna metllinpkf skwwevlenl tleggvtiha tkdlktayfd 301 klnelgklte aiqcktvdad eeqdfdkefl sldlaakfvt stesaiqhin thssrhtdai 361 vtenkanaek fmkgvdssgv ywnastrfad gfrygfgaev gistskihar gpvgldglvs 421 yqyqirgdgq vasdylgagg nkafvhkdld iktvtl // LOCUS NP_014969 602 aa linear PLN 30-JUN-2025 DEFINITION Frt1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014969 VERSION NP_014969.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183744.3 REFERENCE 1 (residues 1 to 602) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 602) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 602) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 602) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 602) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11088. On Jul 30, 2012 this sequence version replaced NP_014969.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..602 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..602 /product="Frt1p" /calculated_mol_wt="67162" CDS 1..602 /gene="FRT1" /locus_tag="YOR324C" /gene_synonym="HPH1" /coded_by="NM_001183744.3:1..1809" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:15189990|PMID:12514182]" /experiment="EXISTENCE:mutant phenotype:GO:0071469 cellular response to alkaline pH [PMID:15189990]" /experiment="EXISTENCE:mutant phenotype:GO:0071472 cellular response to salt stress [PMID:15189990]" /experiment="EXISTENCE:physical interaction:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:21097665]" /note="Tail-anchored ER membrane hypothetical protein; substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation; FRT1 has a paralog, FRT2, that arose from the whole genome duplication" /db_xref="GeneID:854503" /db_xref="SGD:S000005851" ORIGIN 1 mnllidrmen pgsrnctllp psfprgfckg rrassgdavk ikesglqpqp qpeplqaktn 61 vahfsksssr lpviavndnp vvprpstevn lgsllqkere kekeeqpalh drrhlyvtkn 121 rahgvrqrsl emtslpvlgs tktgkfsdfl feddidnrvg rhsrsysgas slddpfrvsp 181 ktdfnsnrar lsclskgrrg smsvfqscht glafnqiqgs sssqrrssag sfdyerkrlv 241 nqflqpslgn sdpfdtlres vvfepsstag giklgnmhsq sqisvnssps tslfyhdldg 301 savndsssfl ysrsnvpafl sssafsstss tssdsedvdr rslngvypsl gyltnqrkpr 361 nssgsstapg tdtlgfkyll nrqksadsst rfksvlkvnn nngsaatpds ssnsisksns 421 nlndnideln yyqnhistll vkienemrrn lndtiiknen nvqktiqkyd llsgeltlll 481 demttlrttv inqflvklks dfdeddnkaf inelkisvee svaqlqgler rmevcqerln 541 kqksslremd slielknvln ksknntksiy lyryfiidii afllmggfiv yvknlltrff 601 tr // LOCUS NP_014971 1574 aa linear PLN 30-JUN-2025 DEFINITION myosin 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014971 VERSION NP_014971.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183746.1 REFERENCE 1 (residues 1 to 1574) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1574) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1574) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1574) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1574) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11089. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1574 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1574 /product="myosin 2" /calculated_mol_wt="180550" Region 2..1567 /region_name="COG5022" /note="Myosin heavy chain [General function prediction only]" /db_xref="CDD:227355" CDS 1..1574 /gene="MYO2" /locus_tag="YOR326W" /gene_synonym="CDC66" /coded_by="NM_001183746.1:1..4725" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:8188749]" /experiment="EXISTENCE:direct assay:GO:0000146 microfilament motor activity [PMID:11381095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:8978821]" /experiment="EXISTENCE:direct assay:GO:0005516 calmodulin binding [PMID:8294515]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:8188749]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:8188749]" /experiment="EXISTENCE:direct assay:GO:0030133 transport vesicle [PMID:23079598]" /experiment="EXISTENCE:direct assay:GO:0031941 filamentous actin [PMID:11381095]" /experiment="EXISTENCE:direct assay:GO:0031982 vesicle [PMID:12456647]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:8188749|PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:11381095]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:12391144|PMID:15201867]" /experiment="EXISTENCE:genetic interaction:GO:0000011 vacuole inheritance [PMID:12594460]" /experiment="EXISTENCE:genetic interaction:GO:0006904 vesicle docking involved in exocytosis [PMID:27307583]" /experiment="EXISTENCE:genetic interaction:GO:0007107 membrane addition at site of cytokinesis [PMID:12456647]" /experiment="EXISTENCE:genetic interaction:GO:0048312 intracellular distribution of mitochondria [PMID:15201867|PMID:12391144]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:12391144|PMID:15201867]" /experiment="EXISTENCE:mutant phenotype:GO:0000011 vacuole inheritance [PMID:8978821]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:10984058]" /experiment="EXISTENCE:mutant phenotype:GO:0007107 membrane addition at site of cytokinesis [PMID:12456647]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:2016335]" /experiment="EXISTENCE:mutant phenotype:GO:0030050 vesicle transport along actin filament [PMID:10562281|PMID:9864365]" /experiment="EXISTENCE:mutant phenotype:GO:0032432 actin filament bundle [PMID:9864365]" /experiment="EXISTENCE:mutant phenotype:GO:0034993 meiotic nuclear membrane microtubule tethering complex [PMID:32059771]" /experiment="EXISTENCE:mutant phenotype:GO:0045033 peroxisome inheritance [PMID:11733545]" /experiment="EXISTENCE:mutant phenotype:GO:0048312 intracellular distribution of mitochondria [PMID:12391144|PMID:15201867]" /experiment="EXISTENCE:mutant phenotype:GO:0048313 Golgi inheritance [PMID:11285273]" /experiment="EXISTENCE:physical interaction:GO:0000011 vacuole inheritance [PMID:12594460]" /experiment="EXISTENCE:physical interaction:GO:0000132 establishment of mitotic spindle orientation [PMID:10984058]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27307583]" /experiment="EXISTENCE:physical interaction:GO:0031267 small GTPase binding [PMID:12391144]" /experiment="EXISTENCE:physical interaction:GO:0045033 peroxisome inheritance [PMID:16678774]" /experiment="EXISTENCE:physical interaction:GO:0071563 Myo2p-Vac17p-Vac8p transport complex [PMID:12594460]" /note="Type V myosin motor involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, lipid droplets, and the mitotic spindle; effector of Ypt11p, a rab-type small GTPase; MYO2 has a paralog, MYO4, that arose from the whole genome duplication" /db_xref="GeneID:854504" /db_xref="SGD:S000005853" ORIGIN 1 msfevgtrcw yphkelgwig aeviknefnd gkyhlelqle ddeivsvdtk dlnndkdqsl 61 pllrnppile atedltslsy lnepavlhai kqrysqlniy tysgivliat npfdrvdqly 121 tqdmiqayag krrgelephl faiaeeayrl mkndkqnqti vvsgesgagk tvsakyimry 181 fasveeensa tvqhqvemse teqkilatnp imeafgnakt trndnssrfg kyleilfdkd 241 tsiigarirt yllersrlvy qppiernyhi fyqlmaglpa qtkeelhltd asdyfymnqg 301 gdtkingidd akeykitvda ltlvgitket qhqifkilaa llhignieik ktrndaslsa 361 depnlklace llgidaynfa kwvtkkqiit rsekivsnln ysqalvakds vakfiysalf 421 dwlvenintv lcnpavndqi ssfigvldiy gfehfeknsf eqfcinyane klqqefnqhv 481 fkleqeeyvk eeiewsfief ndnqpcidli enklgilsll deesrlpags deswtqklyq 541 tldksptnkv fskprfgqtk fivshyaldv aydvegfiek nrdtvsdghl evlkastnet 601 linileglek aakkleeakk leleqagskk pgpirtvnrk ptlgsmfkqs lielmntins 661 tnvhyircik pnadkeawqf dnlmvlsqlr acgvletiri scagfpsrwt feefvlryyi 721 lipheqwdli fkkketteed iisvvkmild atvkdkskyq igntkiffka gmlayleklr 781 snkmhnsivm iqkkirakyy rkqylqisqa ikylqnnikg fiirqrvnde mkvncatllq 841 aayrghsira nvfsvlrtit nlqkkirkel kqrqlkqehe ynaavtiqsk vrtfeprsrf 901 lrtkkdtvvv qslirrraaq rklkqlkada ksvnhlkevs yklenkviel tqnlaskvke 961 nkemterike lqvqveesak lqetlenmkk ehlididnqk skdmelqkti ennlqsteqt 1021 lkdaqleled mvkqhdelke eskkqleele qtkktlveyq tlngdlqnev kslkeeiarl 1081 qtamslgtvt tsvlpqtplk dvmgggasnf nnmmlensdl spndlnlksr stpssgnnhi 1141 dslsvdreng vnatqineel yrlledteil nqeitegllk gfevpdagva iqlskrdvvy 1201 pariliivls emwrfgltkq sesflaqvlt tiqkvvtqlk gndlipsgvf wlanvrelys 1261 fvvfalnsil teetfkngmt deeykeyvsl vtelkddfea lsyniyniwl kklqkqlqkk 1321 ainavvises lpgfsagets gflnkifant eeytmddilt ffnsiywcmk sfhienevfh 1381 avvttllnyv daicfnelim krnflswkrg lqlnynvtrl eewckthglt dgteclqhli 1441 qtakllqvrk ytiedidilr gicysltpaq lqklisqyqv adyespipqe ilryvadivk 1501 keaalsssgn dskghehsss ifitpetgpf tdpfsliktr kfdqveayip awlslpstkr 1561 ivdlvaqqvv qdgh // LOCUS NP_014972 115 aa linear PLN 30-JUN-2025 DEFINITION SNAP receptor SNC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014972 VERSION NP_014972.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183747.3 REFERENCE 1 (residues 1 to 115) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 115) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 115) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 115) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11090. On Jul 30, 2012 this sequence version replaced NP_014972.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..115 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..115 /product="SNAP receptor SNC2" /calculated_mol_wt="12826" Region <1..96 /region_name="SNC1" /note="Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]; COG5143" /db_xref="CDD:227472" CDS 1..115 /gene="SNC2" /locus_tag="YOR327C" /coded_by="NM_001183747.3:1..348" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:14981247]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:16452633]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:36125415|PMID:16452633]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:36125415]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11739407]" /experiment="EXISTENCE:direct assay:GO:0030658 transport vesicle membrane [PMID:15821745]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:11029060]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:9195971]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:8374953]" /experiment="EXISTENCE:physical interaction:GO:0031201 SNARE complex [PMID:9731774]" /note="Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; Snc2p levels regulated by Vps45p; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC2 has a paralog, SNC1, that arose from the whole genome duplication" /db_xref="GeneID:854505" /db_xref="SGD:S000005854" ORIGIN 1 msssvpydpy vppeesnsga npnsqnktaa lrqeiddtvg imrdninkva ergerltsie 61 dkadnlaisa qgfkrganrv rkqmwwkdlk mrmclflvvi illvviivpi vvhfs // LOCUS NP_014973 1564 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette multidrug transporter PDR10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014973 VERSION NP_014973.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183748.1 REFERENCE 1 (residues 1 to 1564) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1564) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1564) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1564) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11091. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1564 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1564 /product="ATP-binding cassette multidrug transporter PDR10" /calculated_mol_wt="176331" Region 110..1556 /region_name="3a01205" /note="Pleiotropic Drug Resistance (PDR) Family protein; TIGR00956" /db_xref="CDD:273362" CDS 1..1564 /gene="PDR10" /locus_tag="YOR328W" /coded_by="NM_001183748.1:1..4695" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19452121]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:1990414 replication-born double-strand break repair via sister chromatid exchange [PMID:23357952]" /note="ATP-binding cassette (ABC) transporter; multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p" /db_xref="GeneID:854506" /db_xref="SGD:S000005855" ORIGIN 1 mlqapsssns glnqgnaapd gppnetqpye gldaaaqeei kelartltsq ssllsqekri 61 tgtgdpntlt aasssslsrs ifasdikgvn pilldvndpd ydetldprse nfssvrwvrn 121 maqicendsd fykpfslgca wkdlsasgds adityqgtfg nmpikylkms wrcisrrlfh 181 rthgksednd sgfqilkpmd gcinpgellv vlgrpgagct tllksisvnt hgfkispdti 241 ityngfsnke iknhyrgevv ynaesdihip hltvfqtlyt varlktprnr ikgvdrdtfa 301 khmtevamat yglshtadtk vgndfvrgvs ggerkrvsia evsicgskfq cwdnatrgld 361 satalefika lktqatitks aatvaiyqcs kdaydlfdkv cvlydgyqif fgpskqakky 421 fqrmgyvcpe rqttadylts itspserikd kdmvkhgimi pqtayemnqy wiqseeykql 481 qvqvnkhldt dssqqreqik nahiakqskr arpsspytvs fflqvkyili rdiwrikndp 541 siqlftvlsh aamalilgsm fyevmlsttt ttfyyrgaai ffailfnafs slleifslye 601 trpitekhkt yslyrpsada fastfsdvpt klatavtfni pyyflinlkr dagafffyfl 661 iniitvfams hlfrcigsvs ktlpqamvpa svlllafamy tgfaiprvqm lgwskwisyi 721 nplsylfesl minefhgrnf pcaqyipsgp nyvnatgdev tcsalgsipg nnyvsgddfi 781 qtnygyrhkn kwrsvgigla yiifflflyl ffceynegak qngemlvfph svvkkmkkkg 841 ivsekkkknq ptlstsdaek dvemnnnssa tdsrflrdsd aaimgndktv akehysspss 901 sasqsnsfsk sddielsksq aifhwknlcy dipikngkrr ildnvdgwvk pgtltaliga 961 sgagkttlld claerttmgl itgdvfvdgr prdqsfprsi gycqqqdlhl ktatvreslr 1021 fsaylrqadd vsieekdkyv eevievlemk lyadaivgvp geglnveqrk rltigvelaa 1081 kpkllvflde ptsgldsqta wstcqlmkkl asrgqailct ihqpsallmq efdrllflqe 1141 ggqtvyfgel gkgcktminy feahgahkcp pdanpaewml eivgaapgth asqdyfaiwr 1201 dseeyremqk eldwmerelp krtegssnee qkefatstly qiklvsyrlf hqywrtpfyl 1261 wskffstivs elfigftffk antslqglqn qmlaifmftv vfnpilqqyl plfvqqrely 1321 earerpsrtf swkafivsqi lveipwnlla gtiaffvyyy pvgfyrnasy anqlhergal 1381 fwlfacafyv yissmgvlvi scieiaenaa nlaslffims lsfcgvlatp nilprfwifm 1441 yrvspltyli dallsvglan asvvcssnel lkivppsgmt cseymepymq stgtgylldg 1501 ssetechfcq fsstndylat vsssysrrwm nygifsayiv fdycaaifly wlvrvpkksk 1561 klkk // LOCUS NP_014974 872 aa linear PLN 30-JUN-2025 DEFINITION Scd5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014974 VERSION NP_014974.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183749.3 REFERENCE 1 (residues 1 to 872) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 872) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 872) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 872) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 872) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 872) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 872) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 872) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 872) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11092. On Jul 30, 2012 this sequence version replaced NP_014974.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..872 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..872 /product="Scd5p" /calculated_mol_wt="97175" Region <433..>658 /region_name="Herpes_BLLF1" /note="Herpes virus major outer envelope glycoprotein (BLLF1); pfam05109" /db_xref="CDD:282904" CDS 1..872 /gene="SCD5" /locus_tag="YOR329C" /gene_synonym="FTB1; SCD7" /coded_by="NM_001183749.3:1..2619" /experiment="EXISTENCE:direct assay:GO:0008157 protein phosphatase 1 binding [PMID:12356757]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:12181333]" /experiment="EXISTENCE:genetic interaction:GO:0030866 cortical actin cytoskeleton organization [PMID:12181333]" /experiment="EXISTENCE:genetic interaction:GO:2000370 positive regulation of clathrin-dependent endocytosis [PMID:12356757]" /experiment="EXISTENCE:mutant phenotype:GO:0005634 nucleus [PMID:16251346]" /experiment="EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:8688556]" /experiment="EXISTENCE:mutant phenotype:GO:0030866 cortical actin cytoskeleton organization [PMID:12956961]" /experiment="EXISTENCE:mutant phenotype:GO:2000370 positive regulation of clathrin-dependent endocytosis [PMID:12356757]" /experiment="EXISTENCE:physical interaction:GO:0008157 protein phosphatase 1 binding [PMID:8754819]" /note="Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency" /db_xref="GeneID:854507" /db_xref="SGD:S000005856" ORIGIN 1 msfdwlnvpg ldlssgdqae krpsnglgpp svsfdfgint aaphdssfwd qgsrshsdtt 61 lsyrnnhsnt aadnatnvss pqkdnppnge vrtlsggdvy aespedmqvp lslsqnqlth 121 eeirtylrwy hyiclrthgk lvrlndvfrf ltnfnlsqkv kdriveifrs cknalnigqf 181 favlrlvsra iiygilplrr milekapvpk prpilssenh eevyeevedd dssaktgdqk 241 vdfdsfasll ltgkttrkrv rrriknlnfk skkvrfsehi tfqdppnlnq essnnseark 301 qdpdaededq dsnndspldf tlpmdqllkr lykrrknsgl vsslpseqqe teeekkvled 361 mkdslshfkq iqtvdsaslp issvflqngn tlptsnvnnt tvpqqlplep lkptatgsan 421 hlvreeynqg lhpsngaiqt glqplkptat gsanylmrsh meqpqsikps stpetvtnsg 481 glqplkptat gsanylmkqh ispsvnnpvs smfqaqftnq ssspqstgpa flnspnitlp 541 qsnqqqpyqe vnptqakiep snispqhtys nnvrinngni vsmpkveitg afppqntlpq 601 hqqshllspq ntipqhqrsq lispqntftq nqpilspqht ysnnqatmis pqntytnnqq 661 qpqhlppppp praqqqqqga ivppqhmysn vqkqnnlvpt qpsytnspsi qspnflspqn 721 aansyfqsll ssspspnptp snastvngnn asngissfqn tsaamnntqs hqtyiqqqqq 781 qqtqqriygg qlsqmqqhpg qlhlnnsdih sqpnkpnygm lgqqvhqqqq qqqqqfpfta 841 dvnrsnssdi lgnlqslqqq vdalqiqynr rp // LOCUS NP_014975 1254 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed DNA polymerase gamma MIP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014975 VERSION NP_014975.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183750.1 REFERENCE 1 (residues 1 to 1254) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1254) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1254) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1254) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1254) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11093. On Dec 12, 2005 this sequence version replaced NP_014975.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1254 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1254 /product="DNA-directed DNA polymerase gamma MIP1" /EC_number="2.7.7.7" /calculated_mol_wt="143372" Region 95..362 /region_name="DNApol_Exo" /note="DNA mitochondrial polymerase exonuclease domain; pfam18136" /db_xref="CDD:465664" Region 581..960 /region_name="DNA_pol_gammaA" /note="Pol gammaA is a family A polymerase that is responsible for DNA replication and repair in mitochondria; cd08641" /db_xref="CDD:176478" Site order(595,599,602..603,652..654,656,658..661,693..694,731, 745,749,852,859,890..892) /site_type="active" /db_xref="CDD:176478" Site order(595,599,602..603,652..654,656,658..661,757,851..852, 855,859,890..892) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:176478" Site order(693..694,696,731,745,749,892) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:176478" CDS 1..1254 /gene="MIP1" /locus_tag="YOR330C" /coded_by="NM_001183750.1:1..3765" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:20601675]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:10567545|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006264 mitochondrial DNA replication [PMID:12023279]" /experiment="EXISTENCE:direct assay:GO:0008408 3'-5' exonuclease activity [PMID:20601675]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:29519802]" /experiment="EXISTENCE:mutant phenotype:GO:0006264 mitochondrial DNA replication [PMID:2684980]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:29519802]" /experiment="EXISTENCE:mutant phenotype:GO:0032043 mitochondrial DNA catabolic process [PMID:29519802]" /note="Mitochondrial DNA polymerase gamma; single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoan complex of catalytic and accessory subunits; polymorphic in yeast, petites occur more frequently in some lab strains; human ortholog POLG complements yeast mip1 mutant; mutations in human POLG associated with Alpers-Huttenlocher syndrome (AHS), progressive external ophthalmoplegia (PEO), parkinsonism, other mitochondrial diseases" /db_xref="GeneID:854508" /db_xref="SGD:S000005857" ORIGIN 1 mtklmvrsec mlrmvrrrpl rvqfcarwfs tkkntaeapr inpvgiqylg eslqrqvfgs 61 cggkdeveqs dklmelskks lkdhglwgkk tlitdpisfp lpplqgrsld ehfqkigrfn 121 sepyksfced kftemvarpa ewlrkpgwvk yvpgmapvev aypdeelvvf dvetlynvsd 181 yptlatalss tawylwcspf icggddpaal iplntlnkeq viighnvayd rarvleeynf 241 rdskaffldt qslhiasfgl csrqrpmfmk nnkkkeaeve sevhpeisie dyddpwlnvs 301 alnslkdvak fhckidldkt drdffastdk stiienfqkl vnycatdvta tsqvfdeifp 361 vflkkcphpv sfaglkslsk cilptklndw ndylnssesl yqqskvqies kivqiikdiv 421 llkdkpdfyl kdpwlsqldw ttkplrltkk gvpakcqklp gfpewyrqlf pskdtvepki 481 tiksriipil fklswenspv iwskesgwcf nvpheqvety kaknyvlads vsqeeeeirt 541 hnlglqctgv lfkvphpngp tfnctnlltk synhffekgv lkseselahq alqinssgsy 601 wmsareriqs qfvvpsckfp nefqslsaks slnnektndl aiiipkivpm gtitrraven 661 awltasnaka nrigselktq vkappgycfv gadvdseelw iaslvgdsif nvhggtaigw 721 mclegtkneg tdlhtktaqi lgcsrneaki fnygriygag akfasqllkr fnpsltdeet 781 kkianklyen tkgktkrskl fkkfwyggse silfnklesi aeqetpktpv lgcgityslm 841 kknlransfl psrinwaiqs sgvdylhllc csmeyiikky nlearlcisi hdeirflvse 901 kdkyraamal qisniwtram fcqqmginel pqncaffsqv didsvirkev nmdcitpsnk 961 taiphgeald inqlldksns klgkpnldid skvsqyayny repvfeeynk sytpeflkyf 1021 lamqvqsdkr dvnrledeyl rectskeyar dgntaeysll dyikdvekgk rtkvrimgsn 1081 fldgtknaka dqrirlpvnm pdyptlhkia ndsaipekql lenrrkkenr iddenkkklt 1141 rkknttpmer kykrvyggrk afeafyecan kpldytlete kqffnipidg viddvlndks 1201 nykkkpsqar tassspirkt akavhskklp arkssttnrn lvelerditi srey // LOCUS NP_014977 233 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V1 sector ATPase subunit E [Saccharomyces cerevisiae S288C]. ACCESSION NP_014977 VERSION NP_014977.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183752.3 REFERENCE 1 (residues 1 to 233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 233) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11094. On Jul 30, 2012 this sequence version replaced NP_014977.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..233 /product="H(+)-transporting V1 sector ATPase subunit E" /calculated_mol_wt="26340" Region 23..223 /region_name="vATP-synt_E" /note="ATP synthase (E/31 kDa) subunit; pfam01991" /db_xref="CDD:396537" CDS 1..233 /gene="VMA4" /locus_tag="YOR332W" /coded_by="NM_001183752.3:1..702" /experiment="EXISTENCE:direct assay:GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain [PMID:16774922]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:23836928|PMID:26928762|PMID:23708375]" /experiment="EXISTENCE:direct assay:GO:0045121 membrane raft [PMID:23836928]" /note="Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase); V-ATPase is an electrogenic proton pump found throughout the endomembrane system; V1 domain has eight subunits; required for the V1 domain to assemble onto the vacuolar membrane; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854509" /db_xref="SGD:S000005859" ORIGIN 1 mssaitaltp nqvndelnkm qafirkeaee kakeiqlkad qeyeiektni vrnetnnidg 61 nfksklkkam lsqqitksti ankmrlkvls areqsldgif eetkeklsgi annrdeykpi 121 lqsliveall kllepkaivk alerdvdlie smkddimrey gekaqraple eivisndyln 181 kdlvsggvvv snasdkiein ntleerlkll seealpairl elygpsktrk ffd // LOCUS NP_014979 470 aa linear PLN 30-JUN-2025 DEFINITION Mrs2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014979 VERSION NP_014979.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183754.1 REFERENCE 1 (residues 1 to 470) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 470) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 470) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 470) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11095. Method: conceptual translation. FEATURES Location/Qualifiers source 1..470 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..470 /product="Mrs2p" /calculated_mol_wt="54072" Region 66..374 /region_name="Mrs2_Mfm1p-like" /note="Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; cd12823" /db_xref="CDD:213357" Site order(77,110,122,124..125,139..142,146,148,182,185, 234..235,238,273) /site_type="other" /note="Cl binding site [ion binding]" /db_xref="CDD:213357" Site order(96,99..100,111,113,151,155,173,176,180,184,187..188, 191,194..195,197..198,201,213..214,216..217,220..221, 224..225,227..228,232,234..235,238..239,242..243,267..268, 270..271,274..275,277..278,281..282,284..285,287..289, 292..299,301..313,315..317,319..324,326..329,333..336, 347..348,351..352,368,371) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:213357" CDS 1..470 /gene="MRS2" /locus_tag="YOR334W" /coded_by="NM_001183754.1:1..1413" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10400670]" /experiment="EXISTENCE:direct assay:GO:0015095 magnesium ion transmembrane transporter activity [PMID:12628916]" /experiment="EXISTENCE:direct assay:GO:0045016 mitochondrial magnesium ion transmembrane transport [PMID:12628916]" /experiment="EXISTENCE:direct assay:GO:1901612 cardiolipin binding [PMID:37721533]" /experiment="EXISTENCE:mutant phenotype:GO:0015095 magnesium ion transmembrane transporter activity [PMID:10400670]" /experiment="EXISTENCE:mutant phenotype:GO:0045016 mitochondrial magnesium ion transmembrane transport [PMID:10400670]" /note="Mitochondrial inner membrane Mg(2+) channel; required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns; similar to bacterial CorA" /db_xref="GeneID:854511" /db_xref="SGD:S000005861" ORIGIN 1 mnrrllvrsi scfqplsrit fgrpntpflr kyadtstaan tnstilrkql lslkpisasd 61 slfisctvfn skgniismse kfpkwsflte hslfprdlrk idnssidiip timckpnciv 121 inllhikali erdkvyvfdt tnpsaaakls vlmydleskl sstknnsqfy ehralesifi 181 nvmsaletdf klhsqiciqi lndlenevnr lklrhlliks kdltlfyqkt llirdlldel 241 lendddlanm yltvkkspkd nfsdlemlie tyytqcdeyv qqsesliqdi ksteeivnii 301 ldanrnslml lelkvtiytl gftvasvlpa fygmnlknfi eesewgftsv avfsivsaly 361 itkknfnslr svtkmtmypn spanssvypk tsasialtnk lkrrrkwwks tkqrlgvlly 421 gssytnkanl snnkinkgfs kvkkfnmend iknkqnrdmi wkwliedkkn // LOCUS NP_014980 958 aa linear PLN 30-JUN-2025 DEFINITION alanine--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014980 VERSION NP_014980.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183755.3 REFERENCE 1 (residues 1 to 958) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 958) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 958) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 958) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 958) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11096. On Jul 30, 2012 this sequence version replaced NP_014980.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..958 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..958 /product="alanine--tRNA ligase" /EC_number="6.1.1.7" /calculated_mol_wt="107146" Region 7..946 /region_name="PLN02900" /note="alanyl-tRNA synthetase" /db_xref="CDD:215487" CDS 1..958 /gene="ALA1" /locus_tag="YOR335C" /gene_synonym="CDC64" /coded_by="NM_001183755.3:1..2877" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:16556230|PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:16556230|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:mutant phenotype:GO:0004813 alanine-tRNA ligase activity [PMID:7761427]" /experiment="EXISTENCE:mutant phenotype:GO:0006419 alanyl-tRNA aminoacylation [PMID:7761427]" /note="Cytoplasmic and mitochondrial alanyl-tRNA synthetase; required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog AARS; mutations in human homolog AARS are associated with autoimmune disease polymyositis/dermatomyositis and with hereditary peripheral neuropathy, Charcot-Marie-Tooth (CMT) disease" /db_xref="GeneID:854513" /db_xref="SGD:S000005862" ORIGIN 1 mtigdkqkwt atnvrntfld yfkskehkfv ksspvvpfdd ptllfanagm nqykpiflgt 61 vdpasdfytl kraynsqkci raggkhndle dvgkdsyhht ffemlgnwsf gdyfkkeait 121 yswtlltevy gipkdrlyvt yfegdeklgl epdtearelw knvgvpddhi lpgnakdnfw 181 emgdqgpcgp cseihydrig grnaaslvnm ddpdvlevwn lvfiqfnreq dgslkplpak 241 hidtgmgfer lvsvlqdvrs nydtdvftpl feriqeitsv rpysgnfgen dkdgidtayr 301 vladhvrtlt faladggvpn negrgyvlrr ilrrgaryar kymnypignf fstlaptlis 361 qvqdifpela kdpaflfeil deeeasfakt ldrgerlfek yasaasktes ktldgkqvwr 421 lydtygfpvd ltelmaeeqg lkidgpgfek akqesyeask rggkkdqsdl iklnvhelse 481 lndakvpktn defkygsanv egtilklhdg tnfvdeitep gkkygiildk tcfyaeqggq 541 eydtgkivid daaefnvenv qlyngfvfht gsleegklsv gdkiiasfde lrrfpiknnh 601 tgthilnfal ketlgndvdq kgslvapekl rfdfshkkav sneelkkved icneqikenl 661 qvfykeipld laksidgvra vfgetypdpv rvvsvgkpie ellanpanee wtkysiefcg 721 gthvnktgdi kyfvileesg iakgirriva vtgteafeaq rlaeqfaadl daadklpfsp 781 ikekklkelg vklgqlsisv itknelkqkf nkiekavkde vksrakkenk qtldevktff 841 etnenapylv kfidispnak aiteainymk sndsvkdksi yllagndpeg rvahgcyisn 901 aalakgidgs alakkvssii ggkaggkgnv fqgmgdkpaa ikdavddles lfkeklsi // LOCUS NP_014981 1365 aa linear PLN 30-JUN-2025 DEFINITION Kre5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014981 VERSION NP_014981.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183756.1 REFERENCE 1 (residues 1 to 1365) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1365) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1365) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1365) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1365) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11097. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1365 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1365 /product="Kre5p" /calculated_mol_wt="156347" Region 254..372 /region_name="Thioredoxin_13" /note="Thioredoxin-like domain; pfam18401" /db_xref="CDD:465749" Region 419..>576 /region_name="Thioredoxin_14" /note="Thioredoxin-like domain; pfam18402" /db_xref="CDD:465750" Region 1095..>1306 /region_name="Glyco_transf_24" /note="Glucosyltransferase 24; pfam18404" /db_xref="CDD:436473" CDS 1..1365 /gene="KRE5" /locus_tag="YOR336W" /coded_by="NM_001183756.1:1..4098" /experiment="EXISTENCE:direct assay:GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity [PMID:9611196]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0070880 fungal-type cell wall beta-glucan biosynthetic process [PMID:9430631]" /note="Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects" /db_xref="GeneID:854514" /db_xref="SGD:S000005863" ORIGIN 1 mrllalvlll lcaplrawty slrygipesa qvwsilvhll gdvdnqlltn lyplvtgldd 61 eidiqenlva ltsnvlrery dkedvadlle lyaslypmgm iqhdissnae qddanssyfv 121 lngnryekpd dvfylkskdl tiqqkvpdvd viqpydvvig tnseapilil ygcptvidsd 181 feefnrnlfm eamngegkfr fiwrstcsld gksveyplth pleitlqngs rmssipqlkk 241 ilytvpkeil vgadnddqlh dlepeelrel dlrvtslise fyqykkdita tlnftksivn 301 nfpliskqli kvssvnkdii tsneelnskg fdynmlglyi ngqnwkitsl tpynlltalk 361 teyqsllkit nllqelepsk cildskflln kfsqfslgkl qnlqpikmdl htipgfsesv 421 iyfndiesdp qydelvnsvq affdkskfge lpeikqnwse iifvidfarl edsevkealg 481 glvravnvvs qgypqrvgll pfssdsdksv vnkiyelkns tdnltelksf letmlladgl 541 sanakhskhi pvpdvfhlld elqidetsii ingeiypfrk nawnyliakv ikkdtefirk 601 elsnsspknk qisvrdllhy ksanlrhnky tpnyfadsvy ssvnntales vcserigyyt 661 kneeynllht itlvddfgsi halkrlrnll htsfvgvrir iihvgdisdi wyqlrgslsq 721 kdpigsintf idalklkkvk shtykksgln qlglhkwlpd iplfelqkgs fialngrfih 781 ldqnevpete hfeaiikrea lrtidsvfal dllfpgfsqe iinpdliemi ssiltrlfyq 841 gthiynngid yttesslprm dlseffrpnn ltmfedgksa sidlllildp leertqmils 901 lveqfrplkf vniqvilmpt lelnivpirr iyvddadivk sitsedsrsd pevdiemdvp 961 nsfivdnnyr ikkllielhs fssktvlstg nidgmggvcl alvdsagnii dktttmktfg 1021 ygqfhtdkfl kgcyikscds rytvqsfstd ghpdfipsds ldilsynpqk iavkiseept 1081 heeeyeegrn ndtiinifti lesgpdeeer ymqmilsils kcpetqkvnf fildqpfisd 1141 tlrksceyin ssdemrgnvi flnyewpqwl rpqrfssrrr dvsrflfldv llpqniskvl 1201 ymsptevpld pfdifqfqgl kraplglfrm sgdgywkegy wekmlrennl efystepafl 1261 vnlerfreld agdkyrihyq ristdamslv nigqdlvnnl qlevpirflk gsykkklvin 1321 decvsewkkk inkfasspgd edvpgesvss kyqdsdnaap lhdel // LOCUS NP_014982 759 aa linear PLN 30-JUN-2025 DEFINITION Tea1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014982 VERSION NP_014982.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183757.3 REFERENCE 1 (residues 1 to 759) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 759) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 759) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 759) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 759) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11098. On Jul 30, 2012 this sequence version replaced NP_014982.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..759 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..759 /product="Tea1p" /calculated_mol_wt="86702" Region 64..105 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(65,69,74..77,79,82,91) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(70,73,80,86,89,96) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 329..579 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..759 /gene="TEA1" /locus_tag="YOR337W" /coded_by="NM_001183757.3:1..2280" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:8524314]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:8524314]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:direct assay:GO:0051285 cell cortex of cell tip [PMID:23673619]" /note="Ty1 enhancer activator involved in Ty enhancer-mediated transcription; required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein" /db_xref="GeneID:854515" /db_xref="SGD:S000005864" ORIGIN 1 mtaplwpnkn eknhtvkral stdmtsnils stnassneen srsssaanvr sgtgantltn 61 ggstrkrlac tncrnrrkkc dlgfpcgncs rlelvcnvnd edlrkkrytn kyvksleshi 121 aqletnlknl vqkiypddeq ilnrmmvgdv lsalpdssqv sinytdqtps lpipatrgtf 181 iiendkvsqp lssfnqqtep stlnsgifnt qkqnfeesld dqlllrrslt pqgekkkkpl 241 vkgslypegp vsykrkhpvk sdsllpvssl taatdpstfs dgitagnsvl vngelkkris 301 dlkttvivrg lnddnpnsin ndprilksls nfykwlypgy fifvhresfl ygffnhsknn 361 yedssycsve liyamcavgs rltpdlqeys evyyqrskkt llqlvfdeqs tarittvqal 421 fclafyelgk gnnqlgwyfs glairvgydm gfqldpkvwy vddnnlqltq seleirsriy 481 wgcyiadhfi clmlgrtstl svsnstmpes delpevngte efrfigrhvl qislplknli 541 ilsrlvqift skifiesedi arklkylntf nsqvynwrqs lpeflqwskt lienddvstd 601 ptisyfwycy yivrltfnkp fiedsqeset vvieiiddlk tlldnfgkkf gnytkgnlyq 661 lyscllainc lkklkeirss eqdswnaqld ffnhifytql ypaydlpkkl qedteleteq 721 enqmlnqvgn inythdfsls heiddlirel fgvgtpqkl // LOCUS NP_014983 363 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR338W [Saccharomyces cerevisiae S288C]. ACCESSION NP_014983 VERSION NP_014983.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183758.1 REFERENCE 1 (residues 1 to 363) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 363) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 363) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 363) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11099. Method: conceptual translation. FEATURES Location/Qualifiers source 1..363 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..363 /product="uncharacterized protein" /calculated_mol_wt="41978" Region 285..354 /region_name="SWIRM" /note="SWIRM domain; pfam04433" /db_xref="CDD:461307" CDS 1..363 /locus_tag="YOR338W" /coded_by="NM_001183758.1:1..1092" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:12586695]" /note="hypothetical protein; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen; YOR338W has a paralog, FUN19, that arose from the whole genome duplication" /db_xref="GeneID:854516" /db_xref="SGD:S000005865" ORIGIN 1 mldnmqfhsp apehpqlngg inkipashki gyklnqqvqr lavvrnniee rlnsmesshg 61 qisdssvvra idasiddfli pspplspklr qcpiisqpql vnvesdhrel imltpvweag 121 lnsqkynhnt rnflsqysff rdmkttkrip nkenrklkvv ksvvnsealp krrrydrkik 181 rrsrelyedd gnrsenydee saqevpvrsv tpirqvkrsl htissplasq gvvnnvpkyi 241 psmsweklpd yspplhtlpn snnkvlkvew kgspmdlnhd plkqrlhpae lvlaqilrlp 301 cdlyldskrr fflekvhrfk kglpfrrtda qkacridvnk asrlfaafek vgwlqdkhfe 361 kyl // LOCUS NP_014984 156 aa linear PLN 30-JUN-2025 DEFINITION putative E2 ubiquitin-protein ligase UBC11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014984 VERSION NP_014984.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183759.3 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11100. On Jul 30, 2012 this sequence version replaced NP_014984.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..156 /product="putative E2 ubiquitin-protein ligase UBC11" /EC_number="2.3.2.23" /calculated_mol_wt="17622" Region 10..151 /region_name="UBCc_UBE2C" /note="Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain of ubiquitin-conjugating enzyme E2 C and related proteins; cd23791" /db_xref="CDD:467411" CDS 1..156 /gene="UBC11" /locus_tag="YOR339C" /coded_by="NM_001183759.3:1..471" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:8982460]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:29519818]" /note="Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2" /db_xref="GeneID:854517" /db_xref="SGD:S000005866" ORIGIN 1 maveeggcvt krlqnellql lssttesisa fpvddndlty wvgyitgpkd tpysglkfkv 61 slkfpqnypf hppmikflsp mwhpnvdksg nicldilkek wsavynveti llslqsllge 121 pnnrsplnav aaelwdadme eyrkkvlacy eeiddy // LOCUS NP_014985 326 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase I subunit RPA43 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014985 VERSION NP_014985.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183760.1 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11101. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..326 /product="DNA-directed RNA polymerase I subunit RPA43" /calculated_mol_wt="36093" Region 32..129 /region_name="RNAP_I_Rpa43_N" /note="Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an N-terminal RNP...; cd04328" /db_xref="CDD:239820" Site order(38..42,44,72,78,82..84,121,126,128) /site_type="other" /note="putative Rpa14 interaction site [polypeptide binding]" /db_xref="CDD:239820" Region 127..250 /region_name="RPA43_OB" /note="RPA43 OB domain in RNA Pol I; pfam17875" /db_xref="CDD:465545" CDS 1..326 /gene="RPA43" /locus_tag="YOR340C" /coded_by="NM_001183760.1:1..981" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:9837969|PMID:11486042]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:7592632]" /note="RNA polymerase I subunit A43" /db_xref="GeneID:854518" /db_xref="SGD:S000005867" ORIGIN 1 msqvkranen retarfikkh kkqvtnpide kngtsncivr vpialyvsla pmylenplqg 61 vmkqhlnplv mkynnkvggv vlgyeglkil dadplskedt seklikitpd tpfgftwchv 121 nlyvwqpqvg dvlegyifiq sashigllih dafnasikkn nipvdwtfvh ndveedadvi 181 ntdenngnnn nednkdsngg snslgkfsfg nrslghwvds ngepidgklr ftvrnvhttg 241 rvvsvdgtli sdadeegngy nssrsqaesl pivsnkkivf ddevsienke shkeldlpev 301 kedngseivy eentsesndg essdsd // LOCUS NP_014986 1664 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase I core subunit RPA190 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014986 VERSION NP_014986.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183761.3 REFERENCE 1 (residues 1 to 1664) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1664) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1664) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1664) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1664) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11102. On Jul 30, 2012 this sequence version replaced NP_014986.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1664 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1664 /product="DNA-directed RNA polymerase I core subunit RPA190" /EC_number="2.7.7.6" /calculated_mol_wt="186301" Region 16..1035 /region_name="RNAP_I_RPA1_N" /note="Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain; cd01435" /db_xref="CDD:259844" Site order(62,65,72,75) /site_type="other" /note="Zn-binding [ion binding]" /db_xref="CDD:259844" Site order(463,468,475,481,591..593,627,629,631,1017..1018) /site_type="active" /note="putative active site region [active]" /db_xref="CDD:259844" Region 989..1611 /region_name="RNA_pol_Rpb1_5" /note="RNA polymerase Rpb1, domain 5; pfam04998" /db_xref="CDD:398596" CDS 1..1664 /gene="RPA190" /locus_tag="YOR341W" /gene_synonym="RRN1" /coded_by="NM_001183761.3:1..4995" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3054507|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15520468]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:1990841 promoter-specific chromatin binding [PMID:27184763]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:2023944]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:3054507]" /note="RNA polymerase I largest subunit A190" /db_xref="GeneID:854519" /db_xref="SGD:S000005868" ORIGIN 1 mdiskpvgse itsvdfgilt akeirnlsak qitnptvldn lghpvsggly dlalgaflrn 61 lcstcgldek fcpghqghie lpvpcynplf fnqlyiylra sclfchhfrl ksvevhryac 121 klrllqygli desykldeit lgslnssmyt ddeaiedned emdgegskqs kdisstllne 181 lkskrseyvd maiakalsdg rttergsfta tvnderkklv hefhkkllsr gkcdncgmfs 241 pkfrkdgftk ifetalnekq itnnrvkgfi rqdmikkqkq akkldgsnea sandeesfdv 301 grnpttrpkt gstyilstev knildtvfrk eqcvlqyvfh srpnlsrklv kadsffmdvl 361 vvpptrfrlp sklgeevhen sqnqllskvl ttsllirdln ddlsklqkdk vsledrrvif 421 srlmnafvti qndvnafids tkaqgrtsgk vpipgvkqal ekkeglfrkh mmgkrvnyaa 481 rsvispdpni etneigvppv favkltypep vtayniaelr qavingpdkw pgatqiqned 541 gslvsligms veqrkalanq lltpssnvst htlnkkvyrh iknrdvvlmn rqptlhkasm 601 mghkvrvlpn ektlrlhyan tgaynadfdg demnmhfpqn enaraealnl antdsqyltp 661 tsgspvrgli qdhisagvwl tskdsfftre qyqqyiygci rpedghttrs kivtlpptif 721 kpyplwtgkq iittvllnvt ppdmpginli sknkikneyw gkgslenevl fkdgallcgi 781 ldksqygask ygivhslhev ygpevaakvl svlgrlftny itataftcgm ddlrltaegn 841 kwrtdilkts vdtgreaaae vtnldkdtpa ddpellkrlq eilrdnnksg ildavtsskv 901 naitsqvvsk cvpdgtmkkf pcnsmqamal sgakgsnvnv sqimcllgqq alegrrvpvm 961 vsgktlpsfk pyetdamagg yvkgrfysgi kpqeyyfhcm agreglidta vktsrsgylq 1021 rcltkqlegv hvsydnsird adgtlvqfmy ggdaiditke shmtqfefcl dnyyallkky 1081 npsaliehld vesalkyskk tlkyrkkhsk ephykqsvky dpvlakynpa kylgsvsenf 1141 qdklesfldk nsklfkssdg vnekkfralm qlkymrslin pgeavgiias qsvgepstqm 1201 tlntfhfagh gaanvtlgip rlreivmtas aaiktpqmtl piwndvsdeq adtfcksisk 1261 vllsevidkv ivtettgtsn taggnaarsy vihmrffdnn eyseeydvsk eelqnvisnq 1321 fihlleaaiv keikkqkrtt gpdigvavpr lqtdvansss nskrleednd eeqshkktkq 1381 avsydepded eietmreaek ssdeegidsd kesdsdsede dvdmneqink siveannnmn 1441 kvqrdrqsai ishhrfitky nfddesgkwc efklelaadt ekllmvnive eicrksiirq 1501 iphidrcvhp epengkrvlv tegvnfqamw dqeafidvdg itsndvaavl ktygveaarn 1561 tivneinnvf sryaisvsfr hldliadmmt rqgtylafnr qgmetstssf mkmsyettcq 1621 fltkavldne reqldspsar ivvgklnnvg tgsfdvlakv pnaa // LOCUS NP_014987 319 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR342C [Saccharomyces cerevisiae S288C]. ACCESSION NP_014987 VERSION NP_014987.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183762.1 REFERENCE 1 (residues 1 to 319) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 319) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 319) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 319) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 319) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11103. Method: conceptual translation. FEATURES Location/Qualifiers source 1..319 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..319 /product="uncharacterized protein" /calculated_mol_wt="36777" CDS 1..319 /locus_tag="YOR342C" /coded_by="NM_001183762.1:1..960" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOR342C has a paralog, YAL037W, that arose from the whole genome duplication" /db_xref="GeneID:854520" /db_xref="SGD:S000005869" ORIGIN 1 mtileelnds sipqrldnhi ffgsvhslth tdflvennir ffinvdlste lishiyhevr 61 skfaheiviv nidndsqipi esdlvrsfhw hntsllqqli hhldflsgin nhgepltppp 121 eshyrnayvq fdhpsdsvsi ldkllygnks eysrtnifqv tneakfqvfn dlitifkysi 181 aqggntnsni lvlsengstd enlisllmst vlkenptfnv yqalqfvksi avipdtvrde 241 kilwvtgfin yqelikknem ywglgsqkgr kltsfaspis kverkqrrrd dqnimrsklp 301 qqrqnpfcst erpkrarcd // LOCUS NP_620389 1770 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_620389 VERSION NP_620389.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184390.4 REFERENCE 1 (residues 1 to 1770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1770) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11104. On Jul 30, 2012 this sequence version replaced NP_620389.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1770 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="202031" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 574..641 /region_name="gag_pre-integrs" /note="GAG-pre-integrase domain; pfam13976" /db_xref="CDD:372857" Region 660..761 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1285..>1468 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1621..1757 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1625..1628,1662..1664,1667,1700,1727,1754) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1770 /locus_tag="YOR343W-B" /gene_synonym="YOR343C-B" /coded_by="join(NM_001184390.4:1..1294, NM_001184390.4:1296..5314)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:854523" /db_xref="SGD:S000007356" ORIGIN 1 mesqqlhqnp hcphgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqeettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqdq hsevpqaktk vrnnvlpphp htseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 ysdiltvlck svskmqtnnq elkdwialan leyngstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lsqqqkeskp trtidsndel pdhllidsga sqtlvrsahy lhhatpnsei 481 nivdaqkqdi pinaignlhf nfqngtktsi kalhtpniay dllslseltn qnitacftrn 541 tlersdgtvl apivkhgdfy wlskkylips hiskltinnv nksksvnkyp yplihrmlgh 601 anfrsiqksl kknavtylke sdiewsnast yqcpdcligk stkhrhvkgs rlkyqesyep 661 fqylhtdifg pvhhlpksap syfisftdek trfqwvyplh drreesilnv ftsilafikn 721 qfnarvlviq mdrgseytnk tlhkfftnrg itacytttad srahgvaerl nrtllndcrt 781 llhcsglpnh lwfsavefst iirnslvspk ndksarqhag lagldittil pfgqpvivnn 841 hnpdskihpr gipgyalhps rnsygyiiyl pslkktvdtt nyvilqnnqt kldqfdydtl 901 tfdddlnrlt ahnqsfieqn eteqsydqnt esdhdyqsei einsdplvnd fssqslnplq 961 ldkepvqkvr apkevdadis eynilpstir srtphiinke stemggties dttsprhsst 1021 ftarnqkrpg spndmidlts qdrvnyglen ikttrlggte epyiqrnsdt nikyrttnst 1081 psiddrssns dsttpiisie tkaacdntps idtdppeyrs sdhatpnimp dkssknvtad 1141 silddlplpd lthksptdts dvskdiphih srqtnsslgg mddsnvlttt kskkrsledn 1201 eteievsrdt wnnknmrsle pprskkrinl iaaikgvksi kpvrttlryd eaitynkdnk 1261 ekdryveayh keisqllkmn twdtnkyydr ndidpkkvin smfifnkkrd gthkarfvar 1321 gdiqhpdtyd sdmqsntvhh yalmtslsia ldndyyitql dissaylyad ikeelyirpp 1381 phlglndkll rlrkslyglk qsganwyeti ksylinccdm qevrgwscvf knsqvticlf 1441 vddmilfskd lnankkiitt lkkqydtkii nlgegdneiq ydilgleiky qrskymklgm 1501 ekslteklpk lnvplnpkgk klrapgqpgh yidqdeleid edeykekvhe mqkliglasy 1561 vgykfrfdll yyintlaqhi lfpsrqvldm tyeliqfmwd trdkqliwhk nkptkpdnkl 1621 vaisdasygn qpyyksqign ifllngkvig gkstkasltc tstteaeiha vseaipllnn 1681 lshlvqelnk kpiikglltd srstisiiks tneekfrnrf fgtkamrlrd evsgnnlyvy 1741 yietkkniad vmtkplpikt fklltnkwih // LOCUS NP_620390 438 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_620390 VERSION NP_620390.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184389.1 REFERENCE 1 (residues 1 to 438) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 438) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 438) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 438) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 438) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11105. Method: conceptual translation. FEATURES Location/Qualifiers source 1..438 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..438 /product="gag protein" /calculated_mol_wt="49737" Region 17..396 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..438 /locus_tag="YOR343W-A" /gene_synonym="YOR343C-A" /coded_by="NM_001184389.1:1..1317" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:854522" /db_xref="SGD:S000007355" ORIGIN 1 mesqqlhqnp hcphgsayas vtskevpsnq dplavsasnl pefdrdstkv nsqeettpgt 61 savpenhhhv spqpasvppp qngqyqqhgm mtpnkamasn wahyqqpsmm tcshyqtspa 121 yyqpdphypl pqyipplsts spdpidsqdq hsevpqaktk vrnnvlpphp htseenfstw 181 vkfyirflkn snlgdiipnd qgeikrqmty eehayiyntf qafapfhllp twvkqilein 241 ysdiltvlck svskmqtnnq elkdwialan leyngstsad tfeitvstii qrlkenninv 301 sdrlacqlil kglsgdfkyl rnqyrtktnm klsqlfaeiq liydenkimn lnkpsqykqh 361 seyknvsrts pnttntkvtt rnyhrtnssk praakahnia tsskfsrvnn dhinestvss 421 qylsddnels lrpateri // LOCUS NP_014989 291 aa linear PLN 30-JUN-2025 DEFINITION Tye7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014989 VERSION NP_014989.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183764.3 REFERENCE 1 (residues 1 to 291) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 291) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 291) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 291) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 291) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11106. On Jul 30, 2012 this sequence version replaced NP_014989.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..291 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..291 /product="Tye7p" /calculated_mol_wt="32558" Region 179..283 /region_name="bHLHzip_SREBP_like" /note="basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; cd11395" /db_xref="CDD:381401" Site order(182,184..186,188..189,191..193,197,250..251) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:381401" Site order(192,195..196,199..200,202..203,206,251..252,255..256, 259,261..263,265..266,268..269,272..273,275..276,279..280, 283) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:381401" CDS 1..291 /gene="TYE7" /locus_tag="YOR344C" /gene_synonym="SGC1" /coded_by="NM_001183764.3:1..876" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:12464632]" /experiment="EXISTENCE:direct assay:GO:0003700 DNA-binding transcription factor activity [PMID:10606743]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:10606743]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:genetic interaction:GO:0045821 positive regulation of glycolytic process [PMID:10606743]" /experiment="EXISTENCE:mutant phenotype:GO:0045821 positive regulation of glycolytic process [PMID:10606743]" /note="Serine-rich protein that contains a bHLH DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression; bHLH stands for basic-helix-loop-helix" /db_xref="GeneID:854525" /db_xref="SGD:S000005871" ORIGIN 1 mnsildrnvr ssettlikpe sefdnwlsde ndgashinvn kdsssvlsas sstwfeplen 61 iissassssi gspiedqfis snneesalfp tdqffsnpss yshspevsss ikreeddnal 121 sladfepasl qlmpnmintd nnddstplkn eielndsfik tnldaketkk raprkrltpf 181 qkqahnkiek ryrinintki arlqqiipwv aseqtafevg dsvkkqdedg aetaattplp 241 saaatstkln ksmilekavd yilylqnner lyemevqrlk seidtlkqdq k // LOCUS NP_014991 985 aa linear PLN 30-JUN-2025 DEFINITION deoxycytidyl transferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_014991 VERSION NP_014991.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183766.1 REFERENCE 1 (residues 1 to 985) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 985) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 985) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 985) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 985) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 985) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 985) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 985) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 985) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11107. Method: conceptual translation. FEATURES Location/Qualifiers source 1..985 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..985 /product="deoxycytidyl transferase" /calculated_mol_wt="112097" Region 165..249 /region_name="BRCT_Rev1" /note="BRCT domain of DNA repair protein Rev1 and similar proteins; cd17719" /db_xref="CDD:349351" Region 315..735 /region_name="PolY_Rev1" /note="DNA polymerase Rev1; cd01701" /db_xref="CDD:176455" Site order(318..320,322..326,328..329,336,362..367,393,401..402, 405,408,414..415,417,464..465,467..468,525,550..557,560, 589..590,621..629,663,684..686,690..694,696) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:176455" Site order(324,362..367,401..402,405,408,414,467..468,525) /site_type="active" /db_xref="CDD:176455" Region 875..981 /region_name="Rev1_C" /note="C-terminal domain of the Y-family polymerase Rev1; cd12145" /db_xref="CDD:213388" Site order(876..881,889..890,893,897,899,903..904,906..907, 910..911) /site_type="other" /note="Polymerase eta interaction site [polypeptide binding]" /db_xref="CDD:213388" CDS 1..985 /gene="REV1" /locus_tag="YOR346W" /coded_by="NM_001183766.1:1..2958" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:16546083]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:8751446]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16452144]" /experiment="EXISTENCE:direct assay:GO:0017125 deoxycytidyl transferase activity [PMID:8751446]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:8751446]" /experiment="EXISTENCE:direct assay:GO:0070987 error-free translesion synthesis [PMID:8751446]" /experiment="EXISTENCE:genetic interaction:GO:0042276 error-prone translesion synthesis [PMID:9765213]" /experiment="EXISTENCE:mutant phenotype:GO:0042276 error-prone translesion synthesis [PMID:17248528]" /experiment="EXISTENCE:mutant phenotype:GO:0070987 error-free translesion synthesis [PMID:10540291]" /experiment="EXISTENCE:physical interaction:GO:0005657 replication fork [PMID:17517887]" /note="Bifunctional DNA-directed DNA polymerase/deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress; may be involved in meiosis" /db_xref="GeneID:854527" /db_xref="SGD:S000005873" ORIGIN 1 mgehgglvdl ldsdleysin retpdknncl sqqsvndshl taktgglnar sflstlsdds 61 lieyvnqlsq tnknnsnpta gtlrfttkni scdelhadlg ggedspiars vieiqesdsn 121 gddvkkntvy treayfheka hgqtlqdqil kdqykdqiss qsskifkncv iyingytkpg 181 rlqlhemivl hggkflhyls skktvthiva snlplkkrie fanykvvspd wivdsvkear 241 llpwqnyslt skldeqqkkl dncktvnsip lpsetslhkg skcvgsallp veqqspvnln 301 nleakrivac ddpdfltsyf ahsrlhhlsa wkanlkdkfl nenihkytki tdkdtyiifh 361 idfdcffatv aylcrsssfs acdfkrdpiv vchgtknsdi ascnyvarsy gikngmwvsq 421 aekmlpngik lislpytfeq fqlkseafys tlkrlnifnl ilpisideav cvriipdnih 481 ntntlnarlc eeirqeifqg tngctvsigc sdslvlarla lkmakpngyn itfksnlsee 541 fwssfklddl pgvghstlsr lestfdsphs lndlrkrytl dalkasvgsk lgmkihlalq 601 gqddeeslki lydpkevlqr kslsidinwg irfknitqvd lfiergcqyl leklneinkt 661 tsqitlklmr rckdapiepp kymgmgrcds fsrssrlgip tnefgiiate mkslyrtlgc 721 ppmelrglal qfnklvdvgp dnnqlklrlp fktivtnraf ealpedvknd innefekrny 781 krkesgltsn slsskkkgfa isrlevndlp stmeeqfmne lptqiraevr hdlriqkkiq 841 qtklgnlqek ikrreeslqn eknhfmgqns ifqpikfqnl trfkkicqlv kqwvaetlgd 901 ggphekdvkl fvkyliklcd snrvhlvlhl snlisrelnl caflnqdhsg fqtwerilln 961 diipllnrnk htyqtvrkld mdfev // LOCUS NP_014992 506 aa linear PLN 30-JUN-2025 DEFINITION pyruvate kinase PYK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014992 VERSION NP_014992.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183767.3 REFERENCE 1 (residues 1 to 506) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 506) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 506) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 506) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11108. On Jul 30, 2012 this sequence version replaced NP_014992.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..506 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..506 /product="pyruvate kinase PYK2" /EC_number="2.7.1.40" /calculated_mol_wt="55064" Region 20..502 /region_name="Pyruvate_Kinase" /note="Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; cd00288" /db_xref="CDD:238178" Site order(22..23,80,82,90..93,181..182,188,191..195,210,218, 225,236,272,290..291,295,327,329,358,360..361,415,417,419, 430,433..434,436,438..440) /site_type="active" /note="domain interfaces [active]" /db_xref="CDD:238178" Site order(51,53,86,216,242,244,268,300) /site_type="active" /db_xref="CDD:238178" CDS 1..506 /gene="PYK2" /locus_tag="YOR347C" /coded_by="NM_001183767.3:1..1521" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16962558]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:mutant phenotype:GO:0004743 pyruvate kinase activity [PMID:9139918]" /experiment="EXISTENCE:mutant phenotype:GO:0006090 pyruvate metabolic process [PMID:9139918]" /note="Pyruvate kinase; appears to be modulated by phosphorylation; transcription repressed by glucose, and Pyk2p may be active under low glycolytic flux; PYK2 has a paralog, CDC19, that arose from the whole genome duplication" /db_xref="GeneID:854529" /db_xref="SGD:S000005874" ORIGIN 1 mpesrlqrla nlkigtpqql rrtsiigtig pktnsceait alrkaglnii rlnfshgsye 61 fhqsvienav kseqqfpgrp laialdtkgp eirtgrtlnd qdlyipvdhq mifttdasfa 121 ntsndkimyi dyanltkviv pgrfiyvddg ilsfkvlqii desnlrvqav nsgyiashkg 181 vnlpntdvdl pplsakdmkd lqfgvrngih ivfasfirts edvlsirkal gsegqdikii 241 skienqqgld nfdeilevtd gvmiargdlg ieilapevla iqkkliakcn lagkpvicat 301 qmldsmthnp rptraevsdv gnavldgadc vmlsgetakg dypvnavnim aataliaest 361 iahlalyddl rdatpkptst tetvaaaata aileqdgkai vvlsttgnta rllskyrpsc 421 piilvtrhar tariahlyrg vfpflyepkr lddwgedvhr rlkfgvemar sfgmvdngdt 481 vvsiqgfkgg vghsntlris tvgqef // LOCUS NP_014993 627 aa linear PLN 30-JUN-2025 DEFINITION proline permease PUT4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014993 VERSION NP_014993.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183768.1 REFERENCE 1 (residues 1 to 627) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 627) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 627) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 627) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 627) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11109. Method: conceptual translation. FEATURES Location/Qualifiers source 1..627 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..627 /product="proline permease PUT4" /calculated_mol_wt="68657" Region 107..593 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..627 /gene="PUT4" /locus_tag="YOR348C" /coded_by="NM_001183768.1:1..1884" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:28679684]" /experiment="EXISTENCE:direct assay:GO:0015175 neutral L-amino acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015804 neutral amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0015812 gamma-aminobutyric acid transport [PMID:8455553]" /experiment="EXISTENCE:direct assay:GO:0015824 proline transport [PMID:10654085]" /experiment="EXISTENCE:genetic interaction:GO:0015193 L-proline transmembrane transporter activity [PMID:14968425]" /experiment="EXISTENCE:genetic interaction:GO:0015812 gamma-aminobutyric acid transport [PMID:8455553]" /experiment="EXISTENCE:mutant phenotype:GO:0015193 L-proline transmembrane transporter activity [PMID:3552672]" /note="Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells" /db_xref="GeneID:854530" /db_xref="SGD:S000005875" ORIGIN 1 mvnilpfhkn nrhsagvvtc addvsgdgsg gdtkkeedvv qvtespssgs rnnhrsdnek 61 ddairmekis knqsassngt iredlimdvd lekspsvdgd sephklkqgl qsrhvqlial 121 ggaigtgllv gtsstlhtcg paglfisyii isaviypimc algemvcflp gdgsdsagst 181 anlvtryvdp slgfatgwny fycyvilvaa ectaasgvve ywttavpkgv witiflcvvv 241 ilnfsavkvy gesefwfasi kilcivglii lsfilfwggg pnhdrlgfry wqhpgafahh 301 ltggslgnft diytgiikga fafilgpelv cmtsaecadq rrniakasrr fvwrliffyv 361 lgtlaisviv pyndptlvna laqgkpgags spfvigiqna gikvlphiin gciltsawsa 421 anafmfastr slltmaqtgq apkclgrink wgvpyvavgv sflcsclayl nvssstadvf 481 nwfsnistis gflgwmcgci aylrfrkaif ynglydrlpf ktwgqpytvw fslivigiit 541 itngyaifip kywrvadfia ayitlpiflv lwfghklytr twrqwwlpvs eidvttglve 601 ieeksreiee mrlpptgfkd kfldall // LOCUS NP_014994 1014 aa linear PLN 30-JUN-2025 DEFINITION Cin1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014994 VERSION NP_014994.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183769.3 REFERENCE 1 (residues 1 to 1014) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1014) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1014) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1014) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1014) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11110. On Jul 30, 2012 this sequence version replaced NP_014994.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1014 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1014 /product="Cin1p" /calculated_mol_wt="116517" Region 1..1012 /region_name="CIN1" /note="Beta-tubulin folding cofactor D [Posttranslational modification, protein turnover, chaperones / Cytoskeleton]; COG5234" /db_xref="CDD:227559" CDS 1..1014 /gene="CIN1" /locus_tag="YOR349W" /coded_by="NM_001183769.3:1..3045" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:2407611]" /experiment="EXISTENCE:genetic interaction:GO:0007021 tubulin complex assembly [PMID:9215891]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9215891]" /note="Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; CIN1 mRNA level is reduced when downstream gene MNE1 is deleted" /db_xref="GeneID:854531" /db_xref="SGD:S000005876" ORIGIN 1 mnnirallds iqsgvqtvsp ekhqqtiaai nkfqddpall dtilprcvpl ltksffcmsq 61 rdqklvaelf ynldkishsk vlksldtsif rlneilnylq draspssfsd vlcvylnlsw 121 lsvillspya fkdkfnktlq vssrfenypi cippinkika vlyfknftda fdqlpereqa 181 nvpflnqflk lfiqssekan yyfsnenlrh lqqvalsndg ikllpklfqi sfnhgshdil 241 daiveffhdh lssnstdtrf qlahsfakia kflhqadpas fielidytie ntvsllqapc 301 dsidsnelht slliiaeval akilpidlvd rvltliipkt chfqkshfqi ikghhirdst 361 nfiiwsvirs nrsnslspqv lqsllshlli naffdpelii ryssfaalqe llgrsnksla 421 lnqndialil qanwkdlprs feensglirr lfnpentsks avcvwkvfrd wsfnwnllen 481 lhlttmklni dynlvpliks klsspallqe vlnkagssvt qncqilylyl klfendvncp 541 kiseicidiy qkkikfqltt qakrqfndns pelfqifvil kywqltgqnd fnqelfwkfv 601 divspqkkln lynefipiiq qiisqcvsln ytrivqliks dneltcrsic hmpdqekmcs 661 lffsqfplls pqsrsllige ldhhwdvris llpsnsyrkf rniiincldd ytitqqgdvg 721 rlvriqalkl mqshpdflsg dcdsinpklt rllaepvpei rklsyqllas atsqitvlsd 781 ssilnfrhkq glseefwkgy avsagaihft dsqltssids fivyyrslsp sqqlelchdl 841 iriipsakqi aesrirdrnk dpltggmrfd tikftihcvk fwtrimesgl vvlhpnfnfq 901 gvfakfynlh lldcttlrvs vikffpflai scyhtmrena dqknlsniil krllvlvkre 961 yaatkskfmt dqnvalqgmf qiflelgvtr qlqalqvacq khelaniles ditl // LOCUS NP_014995 663 aa linear PLN 30-JUN-2025 DEFINITION Mne1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014995 VERSION NP_014995.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183770.1 REFERENCE 1 (residues 1 to 663) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 663) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 663) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 663) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 663) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11111. Method: conceptual translation. FEATURES Location/Qualifiers source 1..663 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..663 /product="Mne1p" /calculated_mol_wt="77099" Region 368..516 /region_name="MNE1" /note="Mitochondrial splicing apparatus component; pfam13762" /db_xref="CDD:372712" CDS 1..663 /gene="MNE1" /locus_tag="YOR350C" /coded_by="NM_001183770.1:1..1992" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:21257754]" /experiment="EXISTENCE:direct assay:GO:1990904 ribonucleoprotein complex [PMID:21257754]" /experiment="EXISTENCE:mutant phenotype:GO:0000372 Group I intron splicing [PMID:21257754]" /experiment="EXISTENCE:mutant phenotype:GO:0090615 mitochondrial mRNA processing [PMID:21257754]" /note="Protein involved in splicing Group I aI5-beta intron from COX1 mRNA; mitochondrial matrix protein" /db_xref="GeneID:854532" /db_xref="SGD:S000005877" ORIGIN 1 mkllfkryss shigklikds litpeilpql grqpsshkrl pnnkrtnsit dkwlkdaltr 61 kdklnedklq nvnlrlnvvl ttlqklrtsd npalyfalln rigtghikwl nksgrqidaf 121 ppdrlplefy helsnmlykl slrsandkia lakfslqlld ryyflktksl tiegkfrani 181 kflrnctlli vksqsnyylr aiqrlfaens egqllanlsq lafyvetsqw tsmldilssc 241 vpdsglrgsk ereraiqlle lfspclvksl kvmiaqnmen eacqilrsls ewnfhfdqhd 301 ssnliqlsqn hsclkvietm nglssttavt rqfgleklpt dvslkqsihi lskdnfeplk 361 qdsflqflsf klsdlplnle vwkkhikevd dqmqaesnlh slraffidml lchlsvrkdf 421 dfmlslvehi vyeknlwqpl lltdnivgnk enstfhclfh gasqdistkl tllalynqln 481 eigyqftshd flsmlkvckn ysdsdffyfa fynllvtqsh kfflfdkfsd kfswrlpiqi 541 gdaisewlss leidiqentd rvlqitddvg ewyvenkpfk sekgtiqpin imelrkifge 601 rktlfhmdse ifqkskakrd kemrnealft andaeynfaa dvsyakrven lfsyirskqm 661 qqk // LOCUS NP_014996 497 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase MEK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014996 VERSION NP_014996.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183771.3 REFERENCE 1 (residues 1 to 497) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 497) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 497) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 497) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 497) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11112. On Jul 30, 2012 this sequence version replaced NP_014996.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..497 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..497 /product="serine/threonine protein kinase MEK1" /EC_number="2.7.11.1" /calculated_mol_wt="56719" Region 24..123 /region_name="FHA_MEK1-like" /note="forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins; cd22670" /db_xref="CDD:438722" Site order(51,63..67,92..93) /site_type="other" /note="phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438722" Region 160..443 /region_name="STKc_CAMK" /note="The catalytic domain of CAMK family Serine/Threonine Kinases; cd05117" /db_xref="CDD:270687" Site order(167,169..172,176,197,199,224,241..244,248,250, 289..290,292,294..295,297,310..311,314,329..333,335) /site_type="active" /db_xref="CDD:270687" Site order(167,169..171,176,197,199,224,241..244,248,294..295, 297,310..311) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270687" Site order(172,248,250,289..290,292,294,314,329..333,335) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270687" Site order(310..318,329..333) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270687" CDS 1..497 /gene="MEK1" /locus_tag="YOR351C" /gene_synonym="MRE4" /coded_by="NM_001183771.3:1..1494" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:27483004|PMID:9832507]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7926789|PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:10786836]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:1752435]" /experiment="EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:10848609]" /note="Meiosis-specific serine/threonine protein kinase; functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids; stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during meiosis" /db_xref="GeneID:854533" /db_xref="SGD:S000005878" ORIGIN 1 mrplyscnla tkddiemagg vapahlevnv ggynteqtip ivkhqlvkvg rndkecqlvl 61 tnpsissvhc vfwcvffded sipmfyvkdc slngtylngl llkrdktyll khcdvielsq 121 gseendikkt rlvfminddl qssldpklld qmgflrevdq weitnrivgn gtfghvlith 181 nskerdedvc yhpenyavki iklkpnkfdk earillrldh pniikvyhtf cdrnnhlyif 241 qdlipggdlf sylakgdclt smseteslli vfqilqalny lhdqdivhrd lkldnillct 301 pepctrivla dfgiakdlns nkermhtvvg tpeycapevg franrkayqs fsraatleqr 361 gydskcdlws lgvithimlt gispfygdgs ersiiqnaki gklnfklkqw divsdnaksf 421 vkdllqtdvv krlnskqglk hiwiakhlsq lerlyykkil cnnegpkles insdwkrklp 481 ksviisqaip kkkkvle // LOCUS NP_014997 343 aa linear PLN 30-JUN-2025 DEFINITION TFIIH complex subunit TFB6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_014997 VERSION NP_014997.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183772.1 REFERENCE 1 (residues 1 to 343) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 343) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 343) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 343) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 343) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11113. Method: conceptual translation. FEATURES Location/Qualifiers source 1..343 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..343 /product="TFIIH complex subunit TFB6" /calculated_mol_wt="39144" Region 164..334 /region_name="TFB6" /note="Subunit 11 of the general transcription factor TFIIH; pfam17110" /db_xref="CDD:465353" CDS 1..343 /gene="TFB6" /locus_tag="YOR352W" /coded_by="NM_001183772.1:1..1032" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:27381459|PMID:22411836]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Subunit of TFIIH complex; facilities dissociation of the Ssl2p helices from TFIIH; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus" /db_xref="GeneID:854534" /db_xref="SGD:S000005879" ORIGIN 1 msepntplha qpneqldlnn lndldekdid dlnldpnsdv eisadsgdvv nsnidnviwq 61 rncnkkrryh tpefndvyne tnntindvtm lddvddfqpr invsspfssa tklsellpnd 121 hngtshprrl smsqqskfis yvddqllqiq rkfvqsrgln ikngyasltp llqdlktlvd 181 fvwysiahvp nsdyllqsee krhcpdsrnp kdtcgyssyf gqgsylikia ddlidyvekf 241 tfknmedsei ndtlsklfkl ffildrifvi ltddndncke vpktssaskn iaglngtdiv 301 rlkgiaertr vrlpiflesq gihgyhyels kiyegfldha nsf // LOCUS NP_014998 791 aa linear PLN 30-JUN-2025 DEFINITION Sog2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014998 VERSION NP_014998.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183773.3 REFERENCE 1 (residues 1 to 791) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 791) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 791) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 791) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 791) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 791) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 791) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 791) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 791) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11114. On Jul 30, 2012 this sequence version replaced NP_014998.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..791 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..791 /product="Sog2p" /calculated_mol_wt="87195" Region <45..>174 /region_name="LRR" /note="Leucine-rich repeat (LRR) protein [Transcription]; COG4886" /db_xref="CDD:443914" Region 68..90 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 91..113 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 114..138 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 139..163 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 299..781 /region_name="SOG2" /note="RAM signalling pathway protein; pfam10428" /db_xref="CDD:431280" CDS 1..791 /gene="SOG2" /locus_tag="YOR353C" /coded_by="NM_001183773.3:1..2376" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:12972564]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:12972564]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0000920 septum digestion after cytokinesis [PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0007118 budding cell apical bud growth [PMID:12972564]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:12972564]" /note="Key component of the RAM signaling network; required for proper cell morphogenesis and cell separation after mitosis" /db_xref="GeneID:854535" /db_xref="SGD:S000005880" ORIGIN 1 mvatsskrtl dpkeehlpad ktstnssnti iselatqeks sssgttlkli alniksisde 61 dvgyiqnver lslrknhlts lpasfkrlsr lqyldlhnnn fkeipyiltq cpqleildls 121 sneiealpde issfwqdnir vlslkdnnvt sirnlksitk lnklsildle dnkipkeeld 181 qvqsytpfht gipkeeywai aisrylkdhp nlptpepkis raakrmgfin tnlsngamne 241 nniislapsa nttisastam vssnqtsats fsgtvnaese qsgavngtel ynhtkyndyf 301 krlsilpees msnghqkish aelvvscrkl lfsftecqqa irkiasfcke kavavnvvsl 361 lysvrshtdn lvevlqqten edeshdqali klcltiitnf kqiitllrkn feiffkeddl 421 cfirmfymtl mcaymemyna wsfikeddqv sgsaskapkk hsfsrhetss ssitsgggpa 481 asttsthcsg nikllpktrs trtpsasall snsniltgdt tavpllspnl ngahthgpil 541 ghqnaisngs sqtnmnevkt tsdtiprqql lqhnksisds kkesqahepk qhpvmtssii 601 nasnsnnvsn vnitpppmng ggaanssanv vetnidiqly qtlstvvkmv svvynqltse 661 iskiaiastm gkqiltdsla pkirdltetc rqamdlskql nerlnvlipn dsnsekylts 721 leklktweim nsflkviisi lantkivmsd vpnlnelrpn lanlakitkd vtvildlssy 781 kavsvsansp e // LOCUS NP_014999 692 aa linear PLN 30-JUN-2025 DEFINITION Msc6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_014999 VERSION NP_014999.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183774.1 REFERENCE 1 (residues 1 to 692) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 692) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 692) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 692) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 692) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11115. Method: conceptual translation. FEATURES Location/Qualifiers source 1..692 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..692 /product="Msc6p" /calculated_mol_wt="79817" CDS 1..692 /gene="MSC6" /locus_tag="YOR354C" /coded_by="NM_001183774.1:1..2079" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:24769239|PMID:23222640|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:26780366]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511544]" /experiment="EXISTENCE:mutant phenotype:GO:0070124 mitochondrial translational initiation [PMID:30767393]" /note="Multicopy suppressor of HER2 involved in mitochondrial translation; mutant is defective in directing meiotic recombination events to homologous chromatids" /db_xref="GeneID:854536" /db_xref="SGD:S000005881" ORIGIN 1 mlshnalraf dcskviisrr cltsstsiyq qssvhlqetd dghsgnrekh vspfervqnl 61 aadlknelka pdsdinevfn dfkdkieslk qklrnpspme rshllanfss dllqelsyrs 121 knmtldpyqv lntlcqykla rsqhftivlk yllynqspqd vialwvkyle tisenpvill 181 qnsssrahmq niaittiayl slpentvdin ilykilqidr kmgqvlpfnm irrmlstefs 241 slerrdviik nlntlyyqyt vqdsdhflsq ienaprwidl rdlygqynkl egeknveiis 301 kfmdkfidld kpdqvvtiyn qyskvfpnst slkdcllrav shlraksske kldrilavwn 361 svikpgdnik ntsyatlvna ltdsgnfnhl kefweeelpk kfkkdpivke afllalcqts 421 plkydqvkge laetvktkkl fnkvlllmld dekvseeqfn tfyynhypsd gvlpptldtl 481 sikmyanykf qaedtrpqfd llqsvsinpt dyekvekitk afisvcptve pirqlykqlg 541 thlnarnyad fisaefnkpd gtvaeaknlf sdflsyqktr krnvdntpln alllgfcdkl 601 ykskhseyvp yiekyynlak dssirvsnla vskilfnlat farntqqlsd kevafinqfm 661 rdlgtnegfr pnpkdiqilk ecdgitvpek lt // LOCUS NP_015000 522 aa linear PLN 30-JUN-2025 DEFINITION Gds1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015000 VERSION NP_015000.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183775.3 REFERENCE 1 (residues 1 to 522) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 522) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 522) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 522) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 522) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11116. On Jul 30, 2012 this sequence version replaced NP_015000.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..522 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..522 /product="Gds1p" /calculated_mol_wt="56917" CDS 1..522 /gene="GDS1" /locus_tag="YOR355W" /coded_by="NM_001183775.3:1..1569" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:34694912]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0062060 NuA4 histone acetyltransferase complex binding [PMID:34694912]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:8750239]" /note="Protein involved in histone H4 acetylation at ribosomal protein genes; interacts with and modulates NuA4 histone acetyltransferase complex; required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a segment predicted to resemble the winged-helix/forkhead domain located in DNA-binding proteins" /db_xref="GeneID:854537" /db_xref="SGD:S000005882" ORIGIN 1 malansrplq iptleneilh nsnspvfqln smgfttradt isnpgtdlig nqpgmalddn 61 nlagssfsss qeikatkpkk dfgapkkdnp lleisklipv tgerpkpenr dspldddvlh 121 avflilwemd pnqqgmtvkq lcdlllqkhp dmsnlstkls nlisaklnay vkkiekgekt 181 ltyalsrews nssprrmlyi yrgilspdyk ehaqavtmql kqqletsgdt sdfnsngkkk 241 resssnqlvn ndsysssmtd mknmssnssf sknlnvgnla fslspefnip ystspvslnl 301 spsmsnnqqq lltpnsasks knnnkkrnym dedtnesmte pkktkttkpg kqtksqslsv 361 lstpkkgssa slstfasskn ispdsslshn assntyvtaa aaaprlskll pkngfkknsr 421 ssselaaihk vistqtpies ssessqynss ssspvnsaaa ssaeslsdin ssqdngresn 481 pssqesrnev tnwmkivrng flthdiespe sitlddleni fn // LOCUS NP_015001 631 aa linear PLN 30-JUN-2025 DEFINITION electron-transferring-flavoprotein dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015001 VERSION NP_015001.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183776.1 REFERENCE 1 (residues 1 to 631) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 631) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 631) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 631) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 631) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11117. Method: conceptual translation. FEATURES Location/Qualifiers source 1..631 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..631 /product="electron-transferring-flavoprotein dehydrogenase" /EC_number="1.5.5.1" /calculated_mol_wt="69503" Region 46..>78 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" Region 70..451 /region_name="FixC" /note="Dehydrogenase (flavoprotein) [Energy production and conversion]; COG0644" /db_xref="CDD:440409" Region 523..629 /region_name="ETF_QO" /note="Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S; pfam05187" /db_xref="CDD:461576" CDS 1..631 /gene="CIR2" /locus_tag="YOR356W" /coded_by="NM_001183776.1:1..1896" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:11502169]" /note="Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase" /db_xref="GeneID:854538" /db_xref="SGD:S000005883" ORIGIN 1 mikftnenli rgirmtisak srhlalgtdm trkfslscrf lnkanlteee kellneprar 61 dyvdvcivgg gpaglataik lkqldnssgt gqlrvvvlek ssvlggqtvs gailepgvwk 121 elfpdeksdi giplpkelat lvtkehlkfl kgkwaisvpe psqminkgrn yivslnqvvg 181 ylgekaeevg vevypgiavs dliydennav kgvitkdagi sksgkpketf ergmefwarq 241 tvlaegchgs ltkqalakyd lrkgrqhqty glgikevwev kpenfnkgfa ahtmgypltn 301 dvygggfqyh fgdglvtvgl vvgldyknpy vspykefqkm khhpyyskvl eggkciayaa 361 ralnegglqs vpklnfpggv lvgasagfmn vpkikgthta mksgllaaes ifesikglpv 421 leevededak mamfdkeati nlesyesafk essiykelye vrnirpsfsg klggyggmiy 481 sgidslilkg kvpwtlkfde kndgeilepa skykpieypk pdgvisfdil tsvsrtgtyh 541 dddepchlrv pgqdmvkyae rsfpvwkgve srfcpagvye fvkdekspvg trlqinsqnc 601 ihcktcdika prqditwkvp eggdgpkytl t // LOCUS NP_015002 162 aa linear PLN 30-JUN-2025 DEFINITION Snx3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015002 VERSION NP_015002.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183777.3 REFERENCE 1 (residues 1 to 162) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 162) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 162) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 162) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 162) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11118. On Jul 30, 2012 this sequence version replaced NP_015002.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..162 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..162 /product="Snx3p" /calculated_mol_wt="18639" Region 35..160 /region_name="PX_Grd19" /note="The phosphoinositide binding Phox Homology domain of fungal Grd19; cd07295" /db_xref="CDD:132828" Site order(81,83,86,112..113,118,127) /site_type="other" /note="phosphoinositide binding site [chemical binding]" /db_xref="CDD:132828" CDS 1..162 /gene="SNX3" /locus_tag="YOR357C" /gene_synonym="GRD19" /coded_by="NM_001183777.3:1..489" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:17420293]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:9456318]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:9456318]" /experiment="EXISTENCE:mutant phenotype:GO:0034499 late endosome to Golgi transport [PMID:12554655]" /note="Sorting nexin for late-Golgi enzymes; required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p" /db_xref="GeneID:854539" /db_xref="SGD:S000005884" ORIGIN 1 mprefksfgs teksllskgh gepsyseiya epenfleiev hnpkthipng mdskgmftdy 61 eiicrtnlps fhkrvskvrr rysdfeffrk clikeismln hpkvmvphlp gkillsnrfs 121 nevieerrqg lntwmqsvag hpllqsgskv lvrfieaekf vg // LOCUS NP_015003 242 aa linear PLN 30-JUN-2025 DEFINITION Hap5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015003 VERSION NP_015003.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183778.1 REFERENCE 1 (residues 1 to 242) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 242) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 242) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 242) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11119. Method: conceptual translation. FEATURES Location/Qualifiers source 1..242 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..242 /product="Hap5p" /calculated_mol_wt="27545" Region 1..>242 /region_name="HAP5" /note="CCAAT-binding factor, subunit C [Transcription]; COG5208" /db_xref="CDD:227533" CDS 1..242 /gene="HAP5" /locus_tag="YOR358W" /coded_by="NM_001183778.1:1..729" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:7828851]" /experiment="EXISTENCE:direct assay:GO:0016602 CCAAT-binding factor complex [PMID:7828851]" /experiment="EXISTENCE:genetic interaction:GO:0043457 regulation of cellular respiration [PMID:7828851]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12614847]" /experiment="EXISTENCE:physical interaction:GO:0016602 CCAAT-binding factor complex [PMID:7828851]" /note="Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex; complex is heme-activated and glucose repressed; complex is a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex" /db_xref="GeneID:854540" /db_xref="SGD:S000005885" ORIGIN 1 mtdrnfspqq gqgpqeslpe gpqpstmiqr eemnmprqys eqqqlqeneg egentrlpvs 61 eeefrmvqel qaiqaghdqa nlppsgrgsl egedngnsdg adgemdedde eydvfrnvgq 121 glvghykeim irywqeline iestnepgse hqddfkshsl pfarirkvmk tdedvkmisa 181 eapiifakac eifiteltmr awcvaernkr rtlqkadiae alqksdmfdf lidvvprrpl 241 pq // LOCUS NP_015004 523 aa linear PLN 30-JUN-2025 DEFINITION Vts1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015004 VERSION NP_015004.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183779.3 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11120. On Jul 30, 2012 this sequence version replaced NP_015004.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..523 /product="Vts1p" /calculated_mol_wt="57426" Region 448..516 /region_name="SAM_VTS1_fungal" /note="SAM domain of VTS1 RNA-binding proteins; cd09556" /db_xref="CDD:188955" Site order(461,463..468,495,497..498,500..501) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:188955" CDS 1..523 /gene="VTS1" /locus_tag="YOR359W" /coded_by="NM_001183779.3:1..1572" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:18469165]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:16429156|PMID:12858164]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20007605]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11445562]" /experiment="EXISTENCE:direct assay:GO:0051054 positive regulation of DNA metabolic process [PMID:20007605]" /experiment="EXISTENCE:direct assay:GO:0070336 flap-structured DNA binding [PMID:20007605]" /experiment="EXISTENCE:mutant phenotype:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:18469165]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:16429156|PMID:12858164]" /experiment="EXISTENCE:physical interaction:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:18469165]" /experiment="EXISTENCE:physical interaction:GO:0051054 positive regulation of DNA metabolic process [PMID:20007605]" /note="Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity; forms [SMAUG+] prion" /db_xref="GeneID:854541" /db_xref="SGD:S000005886" ORIGIN 1 mkhpyeefpt gskspynmsr gahpgavlls pqssainknn pgsnsgnnqg nssvtanvls 61 pqshsmslnd mldqqsfmld tagtraqplq qqqqqqqqqq qaslpslniq tvsstaagsa 121 ivspmmqspk alqstlssts myldsfqrsp nnilgipsqs gsiplpqsrq sqqqsqsqkn 181 dpnmgtnfsq dinqlcswis mlnssqqntv mdnilsilnd dvlkytklki etltntpfis 241 pplpaiaspi pnrddtqiln idsvfssspi tndpentdnl lyqnwspqph sipisqpiyd 301 nitdasqrsk saephvnssp nlipvqkqfn ngnstkykkl psenpnylsh slssshsffq 361 pkkrsnmgne ynshhhhslh hplhnttsyf sntsrpsgtd lnksnqnvfn ntithpnagp 421 tsatststss ngntplssns smnpksltdp kllknipmwl kslrlhkysd alsgtpwiel 481 iylddetlek kgvlalgarr kllkafgivi dykerdlidr say // LOCUS NP_015005 526 aa linear PLN 30-JUN-2025 DEFINITION 3',5'-cyclic-nucleotide phosphodiesterase PDE2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015005 VERSION NP_015005.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183780.1 REFERENCE 1 (residues 1 to 526) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 526) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 526) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 526) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 526) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11121. Method: conceptual translation. FEATURES Location/Qualifiers source 1..526 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..526 /product="3',5'-cyclic-nucleotide phosphodiesterase PDE2" /EC_number="3.1.4.53" /calculated_mol_wt="60869" Region 264..512 /region_name="PDEase_I" /note="3'5'-cyclic nucleotide phosphodiesterase; pfam00233" /db_xref="CDD:459723" CDS 1..526 /gene="PDE2" /locus_tag="YOR360C" /gene_synonym="SRA5" /coded_by="NM_001183780.1:1..1581" /experiment="EXISTENCE:direct assay:GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity [PMID:3025832]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway [PMID:8391474]" /note="High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon" /db_xref="GeneID:854542" /db_xref="SGD:S000005887" ORIGIN 1 mstlfligih eieksqtivq nehyfdrvie lqdldslmva lykdrvspfp nvhnfetgvs 61 ivlydpskfq lsvrqldvlf krffpsfnis aidhtreenl qrlecveren sicrnritri 121 nhwmyhhhdd tpdginknsy gtvngnsvpt qaceaniytl llhlndskaq hlrkasvprl 181 irniefmsfl sdpiekisqe gshywnilst wdfcalslst qeliwcgftl ikklskdakv 241 liadnkllll lftlessyhq vnkfhnfrha idvmqatwrl ctyllkdnpv qtlllcmaai 301 ghdvghpgtn nqllcncese vaqnfknvsi lenfhrelfq qllsehwpql lsiskkkfdf 361 iseailatdm alhsqyedrl mhenpmkqit lisliikaad isnvtrtlsi sarwaylitl 421 efndcallet fhkahrpeqd cfgdsyknvd spkedlesiq nilvnvtdpd diikdhphip 481 ngqiffintf aevffnalsq kfsglkflsd nvkinkeywm khkkpq // LOCUS NP_015006 763 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF3 core subunit b [Saccharomyces cerevisiae S288C]. ACCESSION NP_015006 VERSION NP_015006.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183781.3 REFERENCE 1 (residues 1 to 763) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 763) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 763) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 763) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 763) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11122. On Jul 30, 2012 this sequence version replaced NP_015006.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..763 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..763 /product="translation initiation factor eIF3 core subunit b" /calculated_mol_wt="87999" Region 76..158 /region_name="RRM_eIF3B" /note="RNA recognition motif (RRM) found in eukaryotic translation initiation factor 3 subunit B (eIF-3B) and similar proteins; cd12278" /db_xref="CDD:409720" Site order(78,80,82..83,113,124,126,128,156,158) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:409720" Site order(81,84,91,94..95,97..99,101..102,105,143..146, 148..149,154..155) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:409720" Region 200..746 /region_name="COG5354" /note="Uncharacterized protein, contains Trp-Asp (WD) repeat [General function prediction only]" /db_xref="CDD:227657" CDS 1..763 /gene="PRT1" /locus_tag="YOR361C" /gene_synonym="CDC63; DNA26" /coded_by="NM_001183781.3:1..2292" /experiment="EXISTENCE:direct assay:GO:0002183 cytoplasmic translational initiation [PMID:7798228]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:9671501|PMID:7876188]" /experiment="EXISTENCE:direct assay:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9660829|PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:9671501]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:19470581]" /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:11018020|PMID:15838098]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:3029094]" /experiment="EXISTENCE:physical interaction:GO:0005852 eukaryotic translation initiation factor 3 complex [PMID:9660829]" /note="eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes; eIF3 is also involved in programmed stop codon readthrough" /db_xref="GeneID:854543" /db_xref="SGD:S000005888" ORIGIN 1 mknflprtlk niyelyfnni svhsivsrnt qlkrskiiqm ttetfedikl edipvddidf 61 sdleeqykvt eefnfdqyiv vngapvipsa kvpvlkkalt slfskagkvv nmefpideat 121 gktkgflfve cgsmndakki iksfhgkrld lkhrlflytm kdverynsdd fdtefrepdm 181 ptfvpssslk swlmddkvrd qfvlqddvkt svfwnsmfne edslvesren wstnyvrfsp 241 kgtylfsyhq qgvtawggpn fdrlrrfyhp dvrnssvspn ekylvtfste piiveednef 301 spftkknegh qlciwdiasg llmatfpvik spylkwplvr wsyndkycar mvgdslivhd 361 atknfmplea kalkpsgird fsfapegvkl qpfrngdeps vllaywtpet nnsactatia 421 evprgrvlkt vnlvqvsnvt lhwqnqaefl cfnverhtks gktqfsnlqi crlterdipv 481 ekvelkdsvf efgwephgnr fvtisvheva dmnyaipant irfyapetke ktdvikrwsl 541 vkeipktfan tvswspagrf vvvgalvgpn mrrsdlqfyd mdypgeknin dnndvsaslk 601 dvahptysaa tnitwdpsgr yvtawssslk hkvehgykif niagnlvked iiagfknfaw 661 rprpasilsn aerkkvrknl rewsaqfeeq dameadtamr dlilhqrell kqwteyreki 721 gqemeksmnf kifdvqpeda sddfttieei veevleetke kve // LOCUS NP_015007 288 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit alpha 7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015007 VERSION NP_015007.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183782.1 REFERENCE 1 (residues 1 to 288) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 288) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 288) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 288) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11123. Method: conceptual translation. FEATURES Location/Qualifiers source 1..288 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..288 /product="proteasome core particle subunit alpha 7" /calculated_mol_wt="31405" Region 5..219 /region_name="proteasome_alpha_type_3" /note="The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming...; cd03751" /db_xref="CDD:239720" Site order(10..13,15..16,18..19,23,26,29..30,33,41,56,58..59, 82..84,86..87,118,121,124..125,128..132,149,154..155,157, 159..160,162) /site_type="other" /note="alpha subunit interaction site [polypeptide binding]" /db_xref="CDD:239720" Site order(35,51,53,66,167) /site_type="active" /db_xref="CDD:239720" CDS 1..288 /gene="PRE10" /locus_tag="YOR362C" /coded_by="NM_001183782.1:1..867" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019773 proteasome core complex, alpha-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0034515 proteasome storage granule [PMID:18504300]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:19029916|PMID:11545745]" /note="Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:854544" /db_xref="SGD:S000005889" ORIGIN 1 mtsigtgydl snsvfspdgr nfqveyavka vengttsigi kcndgvvfav eklitskllv 61 pqknvkiqvv drhigcvysg lipdgrhlvn rgreeaasfk klyktpipip afadrlgqyv 121 qahtlynsvr pfgvstifgg vdkngahlym lepsgsywgy kgaatgkgrq sakaeleklv 181 dhhpeglsar eavkqaakii ylahednkek dfeleiswcs lsetnglhkf vkgdllqeai 241 dfaqkeingd ddededdsdn vmssddenap vatnanattd qegdihle // LOCUS NP_015008 996 aa linear PLN 30-JUN-2025 DEFINITION oleate-activated transcription factor PIP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015008 VERSION NP_015008.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183783.3 REFERENCE 1 (residues 1 to 996) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 996) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 996) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 996) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 996) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 996) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 996) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 996) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 996) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11124. On Jul 30, 2012 this sequence version replaced NP_015008.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..996 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..996 /product="oleate-activated transcription factor PIP2" /calculated_mol_wt="114580" Region 20..55 /region_name="GAL4" /note="GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6)motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations; cd00067" /db_xref="CDD:238023" Site order(20,24,29..32,34,37,47) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(25,28,35,42,45,52) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 274..676 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..996 /gene="PIP2" /locus_tag="YOR363C" /gene_synonym="OAF2" /coded_by="NM_001183783.3:1..2991" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9288897]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:10428786]" /experiment="EXISTENCE:direct assay:GO:0089716 Pip2-Oaf1 complex [PMID:9288897]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9288897]" /experiment="EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9288897]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:8972187|PMID:10428786]" /experiment="EXISTENCE:mutant phenotype:GO:0032000 positive regulation of fatty acid beta-oxidation [PMID:8670793|PMID:8972187]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9288897|PMID:8972187|PMID:8670793]" /experiment="EXISTENCE:mutant phenotype:GO:0071400 cellular response to oleic acid [PMID:8972187]" /experiment="EXISTENCE:physical interaction:GO:0089716 Pip2-Oaf1 complex [PMID:8972187]" /note="Autoregulatory, oleate-activated transcription factor; subunit of a heterodimeric complex with Oaf1p, which binds to oleate-response elements (ORE) in the promoter of genes involved in beta-oxidation of fatty acids, peroxisome organization and biogenesis, activating transcription in the presence of oleate; PIP2 has a paralog, OAF1, that arose from the whole genome duplication" /db_xref="GeneID:854545" /db_xref="SGD:S000005890" ORIGIN 1 myftdesspa mnrvgkkrnr lsfvcqacrk aktkcdqekp rcgrctkqnl fciydvarqa 61 aprnpnkdat iarlkkeiry wrnktvdltq ekkdfytalk rpteelaarr tckslqensf 121 pislykthpr limtkvmkre inplsekyli fqdtflktli asvllscsrn smipalnadi 181 srsrtqpcvk nnvvkmrevl lknskyesqr ksineftdrl lqrknpeeqi avnkvislly 241 snressyled tcptendysd llkgyineie ktlppkaiie qylshffehi fhlipfaske 301 mleesihttv qynelgevrl smgttlirnk menlcillli lriayisltf iedkiedysp 361 yitkemleqy piqsevifla qqilasenwc acanentisc llyiwcafvf sptegdflle 421 qpsdviinlv iligtsiglh rdpsdfpaln hpeasdkrll nlrriqwlsi ismatlessl 481 kgrllvspls midlfidvrd pncveiykkr vkkdltgses deqlleihei ffhraqlalf 541 lsdlnnitis ysgsvpmdtl etlrvkanel lknkfqlrsv diniydeekt fqkltfnsil 601 nsislsgqil gklmmlrasi almlyfetla merseclsff ykyffqccad tislirfffl 661 yfngsyekvl sslvcfittk viqlavpttm ftllviimrv elaknmllvk cnecnargdi 721 sdlpeikeki ksldtikenf erlllevyll asqnlrfkyf yifkmltlfd vfiqrlrkgq 781 lfsglfvkvd kdlttkkiat mleltlginl dksdhlidrl kgknltvnft ldqlyqiike 841 fdriknigva dpqnslnpsk pnmkdntpti elllnssven esvppysssn dptnvgnast 901 yslahnisnq nneenmppsi gssesnraap nlnfmpinnn ynnsgsninn ndnvklpsnf 961 knyydppmss ldismdvpdi fgsldffdyd llfqnd // LOCUS NP_015010 703 aa linear PLN 30-JUN-2025 DEFINITION putative flavin adenine dinucleotide transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_015010 VERSION NP_015010.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183785.1 REFERENCE 1 (residues 1 to 703) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 703) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 703) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 703) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 703) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 703) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 703) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 703) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 703) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11125. Method: conceptual translation. FEATURES Location/Qualifiers source 1..703 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..703 /product="putative flavin adenine dinucleotide transporter" /calculated_mol_wt="80154" Region 60..199 /region_name="TRP_N" /note="ML-like domain; pfam14558" /db_xref="CDD:434037" Region 204..652 /region_name="TRP" /note="Transient receptor potential (TRP) ion channel; pfam06011" /db_xref="CDD:428720" CDS 1..703 /locus_tag="YOR365C" /coded_by="NM_001183785.1:1..2112" /experiment="EXISTENCE:genetic interaction:GO:0030148 sphingolipid biosynthetic process [PMID:27462707]" /note="Putative protein involved in sphingolipid biosynthesis; not an essential gene; YOR365C has a paralog, FLC2, that arose from the whole genome duplication" /db_xref="GeneID:854548" /db_xref="SGD:S000005892" ORIGIN 1 mlpikvfsls rifvllaifr qihaisinss tfqvsnsftl lnnastlfpv pfdaytkeyl 61 rtsalltcak dsqfsasyfe aaffprnntl ffnveaqtim senitikael iayglnvytk 121 vfdlcgiqdn llcplkpgni elmgsyyvea avasqipsit ynipdldayi vvtaystidk 181 eftkplacvq vmlsngrtvq teylswnlvi ltisgimfsv vyslqgytvt strlasysis 241 lllyfqnlai lamisvsflp pivaawtqnf qwsmgiirin fmqrlfdwyv vatsgsptvv 301 yrnkevlsis vqkrslnski isassnlngi essqkndlly tsnlrnsndy lskilvlrgi 361 krvsykagie isnffltgfs ffiificmii lafiifktfl kvlqkfkvkt irylhfhthw 421 sallqgtlyr avfiiyseis llalweftqt dsaatlveai vvfilitvll ssasvriwrk 481 mikskkifgq psyllfsssk flnkfgflss qfkstkvwwl matsahmlir silvgslqah 541 gksqsigifl neaiylillc wmqpymdktt nffnisihsl nlvnaffflf fsnlfqqpia 601 vssfmgliff flnaafslyl fifilicftm aiyykhpdtr ykpiddqrrs flkgemddda 661 vyesvpelhe mkkavlecng iqkpqinkid lckqnsncey lym // LOCUS NP_015012 200 aa linear PLN 30-JUN-2025 DEFINITION Scp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015012 VERSION NP_015012.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183787.3 REFERENCE 1 (residues 1 to 200) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 200) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 200) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 200) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11126. On Jul 30, 2012 this sequence version replaced NP_015012.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..200 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..200 /product="Scp1p" /calculated_mol_wt="22617" Region 15..200 /region_name="SCP1" /note="Calponin [Cytoskeleton]; COG5199" /db_xref="CDD:227526" CDS 1..200 /gene="SCP1" /locus_tag="YOR367W" /coded_by="NM_001183787.3:1..603" /experiment="EXISTENCE:direct assay:GO:0007015 actin filament organization [PMID:12857851]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:12857851]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:12857851]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:12857851]" /note="Component of yeast cortical actin cytoskeleton; binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin" /db_xref="GeneID:854549" /db_xref="SGD:S000005894" ORIGIN 1 msydkkadvt sldedlrqlr eskfspeaiq nikiwvyksv lkeiappgdl leclkdgtvl 61 cklanilyea dtgeanhisw ksskmpfvqm dqisqflsfs rkygvpedel fqtidlfekk 121 dpaivfqtlk slsryankkh tdrfpvlgpq lstkkprppv kskpkhlqdg tgwstfeygy 181 mkgasqateg vvlgqrrdiv // LOCUS NP_015013 401 aa linear PLN 30-JUN-2025 DEFINITION Rad17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015013 VERSION NP_015013.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183788.1 REFERENCE 1 (residues 1 to 401) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 401) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 401) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 401) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11127. Method: conceptual translation. FEATURES Location/Qualifiers source 1..401 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..401 /product="Rad17p" /calculated_mol_wt="45449" Region 11..271 /region_name="Rad1" /note="Repair protein Rad1/Rec1/Rad17; pfam02144" /db_xref="CDD:396631" CDS 1..401 /gene="RAD17" /locus_tag="YOR368W" /coded_by="NM_001183788.1:1..1206" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:12604797]" /experiment="EXISTENCE:direct assay:GO:0030896 checkpoint clamp complex [PMID:12604797|PMID:9891048]" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:9564050]" /experiment="EXISTENCE:mutant phenotype:GO:0006302 double-strand break repair [PMID:17624540]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10511543]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:11356855]" /note="Checkpoint protein; involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins" /db_xref="GeneID:854550" /db_xref="SGD:S000005895" ORIGIN 1 mrinselank fsastvhleh ittalscltp fgskddvlif idadglsfvr ennhvikiql 61 llsrelfmsy syrnetedhm klcvkinhil dsvsvmnrns ddivectlsy dghgspfvli 121 fedsfiserv eystylikdf dtngleldre risfeaiikg ealhsalkdl keigckecyv 181 yakteanden vfalisksql gfskiklpsn rsileklqvf dgdsttvidg favigffdft 241 sfdkirkstk iaskvlfrmd vhgvlsvnil sqtddviitd ttrpsnnrpg sirqlqlpkd 301 ypgivievcm lekesideaa qteiellmet nelgnrnsfk kstirkrygt dkgnetsndn 361 llqlngkkik lpseeennkn resedeenhc kyptkdipif f // LOCUS NP_015014 143 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS12 RPS12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015014 VERSION NP_015014.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183789.3 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11128. On Jul 30, 2012 this sequence version replaced NP_015014.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..143 /product="40S ribosomal protein eS12 RPS12" /calculated_mol_wt="15341" Region 26..114 /region_name="Ribosomal_L7Ae" /note="Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; pfam01248" /db_xref="CDD:426153" CDS 1..143 /gene="RPS12" /locus_tag="YOR369C" /coded_by="NM_001183789.3:1..432" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:3533916]" /experiment="EXISTENCE:direct assay:GO:1990145 maintenance of translational fidelity [PMID:32408794]" /experiment="EXISTENCE:mutant phenotype:GO:0000028 ribosomal small subunit assembly [PMID:32408794]" /experiment="EXISTENCE:mutant phenotype:GO:0030490 maturation of SSU-rRNA [PMID:32408794]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog" /db_xref="GeneID:854551" /db_xref="SGD:S000005896" ORIGIN 1 msdveevvev qeetvveqta evtiedalkv vlrtalvhdg larglrestk altrgeallv 61 vlvssvtean iiklveglan dpenkvplik vadakqlgew aglgkidreg narkvvgasv 121 vvvknwgaet delsmimehf sqq // LOCUS NP_015015 603 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein MRS6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015015 VERSION NP_015015.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183790.1 REFERENCE 1 (residues 1 to 603) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 603) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 603) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 603) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 603) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11129. Method: conceptual translation. FEATURES Location/Qualifiers source 1..603 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..603 /product="GTPase-activating protein MRS6" /calculated_mol_wt="67243" Region 44..510 /region_name="MRS6" /note="RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; COG5044" /db_xref="CDD:227377" CDS 1..603 /gene="MRS6" /locus_tag="YOR370C" /gene_synonym="MSI4" /coded_by="NM_001183790.1:1..1812" /experiment="EXISTENCE:direct assay:GO:0004663 Rab geranylgeranyltransferase activity [PMID:8183917]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9202009|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005968 Rab-protein geranylgeranyltransferase complex [PMID:8183917|PMID:8583924]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9202009]" /experiment="EXISTENCE:mutant phenotype:GO:0004663 Rab geranylgeranyltransferase activity [PMID:8183917]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:8183917]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:8132658]" /experiment="EXISTENCE:mutant phenotype:GO:0018344 protein geranylgeranylation [PMID:12972569]" /experiment="EXISTENCE:mutant phenotype:GO:0031267 small GTPase binding [PMID:12972569]" /note="Rab escort protein; type II geranylgeranyltransferase complex (Bet2p-Bet4p) chaperone that complexes with newly synthesized Rab GTPases, like Ypt1p and Sec4p, leading to their prenylation and membrane delivery; modulates the TOR pathway through interactions with Sfp1p; alters the kinetics of MAPK pathway activation and polarity reorganization during filamentous growth; sequence similarity to mammalian choroideraemia gene; relative distribution to the nucleus increases upon DNA replication stress" /db_xref="GeneID:854552" /db_xref="SGD:S000005897" ORIGIN 1 mlsperrpsm aerrpsffsf tqnpsplvvp hlagiedplp attpdkvdvl iagtgmvesv 61 laaalawqgs nvlhidkndy ygdtsatltv dqikrwvnev negsvscykn aklyvstlig 121 sgkyssrdfg idlspkilfa ksdllsilik srvhqylefq slsnfhtyen dcfekltntk 181 qeiftdqnlp lmtkrnlmkf ikfvlnweaq teiwqpyaer tmsdflgekf klekpqvfel 241 ifsiglcydl nvkvpealqr irryltsfdv ygpfpalcsk yggpgelsqg fcrsaavgga 301 tyklneklvs fnpttkvatf qdgskvevse kviisptqap kdskhvpqqq yqvhrltciv 361 enpctewfne gesaamvvfp pgslksgnke vvqafilgag seicpegtiv wylstteqgp 421 raemdidaal eamemallre sssglendee ivqltgnght ivnsvklgqs fkeyvprerl 481 qflfklyytq ytstppfgvv nssffdvnqd lekkyipgas dngviyttmp saeisydevv 541 taakvlyeki vgsdddffdl dfededeiqa sgvanaeqfe naidddddvn megsgefvge 601 mei // LOCUS NP_015016 897 aa linear PLN 30-JUN-2025 DEFINITION Gpb1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015016 VERSION NP_015016.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183791.3 REFERENCE 1 (residues 1 to 897) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 897) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 897) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 897) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 897) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11130. On Jul 30, 2012 this sequence version replaced NP_015016.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..897 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..897 /product="Gpb1p" /calculated_mol_wt="100809" CDS 1..897 /gene="GPB1" /locus_tag="YOR371C" /gene_synonym="KRH2" /coded_by="NM_001183791.3:1..2694" /experiment="EXISTENCE:direct assay:GO:0000209 protein polyubiquitination [PMID:20160012]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16030250]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:20160012]" /experiment="EXISTENCE:genetic interaction:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]" /experiment="EXISTENCE:genetic interaction:GO:0004862 cAMP-dependent protein kinase inhibitor activity [PMID:16924114|PMID:16278446]" /experiment="EXISTENCE:genetic interaction:GO:0007124 pseudohyphal growth [PMID:12150916]" /experiment="EXISTENCE:genetic interaction:GO:0042326 negative regulation of phosphorylation [PMID:16278446]" /experiment="EXISTENCE:genetic interaction:GO:0046580 negative regulation of Ras protein signal transduction [PMID:16793550]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:20160012]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0010255 glucose mediated signaling pathway [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0046579 positive regulation of Ras protein signal transduction [PMID:20160012]" /experiment="EXISTENCE:physical interaction:GO:0032794 GTPase activating protein binding [PMID:16793550]" /note="Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; GPB1 has a paralog, GPB2, that arose from the whole genome duplication" /db_xref="GeneID:854553" /db_xref="SGD:S000005898" ORIGIN 1 mpqastfgsh sleahplhiq pavhiklske ershyreqyd slkyisnyvs vfdqalsdni 61 dsrirkenea llkkyyesrk pftftsfrqg svisssdsst gftertktyc flndfvsncv 121 nevdpytlkm tvrnrntaln menldderks kddiydfedn tddecnakch gafhysserl 181 eilrsrstis yfkyykkllt vdlrdsdvlk rhnlwmpmit rrfrfllvss skpedvrltt 241 piptfsesdl difknktcpl fingtdcvpr sydtfsgssv iasifseykl pslsyhcsve 301 lndqlfivgg lmachrydee apdlkdfyvd giknlpppli pelinnpsmi pnphlycfsl 361 tssrltrpdi sgyippplvc tqgcklterh iflyggfeik setqvddkgr yfirkrafln 421 ntgyildtvt fnfskielva ppyqfaiynn fsprfghmqa sisnsnnnvs nentttsakg 481 rrsispyrqg ngdhkiddlv gspgstdyle ddaippvtnp rstdslsskh cstathicss 541 vntilifggy sqtgddkyea mndmwkinip vvsrgkrnyy kfadtvtatk ipiiddpelw 601 psrrafsacc vpdyftkdve pietrllrnl kndfsidlei rpgnkpsqpl fpniphsrke 661 kksgrdsmhi snsnnstsed tsskstrntt sspptspkht pplnpskkca sigrtiafhg 721 gsdgydvcsd mwwfdfdset wtkidlyakt qeesdglvpi nlcmvghsmt tvghkvvlig 781 glrqgdvdri yrdetlpeev isgvplgsgv invvdlntqc lqgcklirnd gdtkesvimd 841 phvgtphqvl avagtielvk gtmtliggvv agredissly lrgavlqfil psmnlan // LOCUS NP_015017 554 aa linear PLN 30-JUN-2025 DEFINITION Ndd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015017 VERSION NP_015017.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183792.1 REFERENCE 1 (residues 1 to 554) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 554) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 554) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 554) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 554) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11131. Method: conceptual translation. FEATURES Location/Qualifiers source 1..554 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..554 /product="Ndd1p" /calculated_mol_wt="60392" CDS 1..554 /gene="NDD1" /locus_tag="YOR372C" /coded_by="NM_001183792.1:1..1665" /experiment="EXISTENCE:direct assay:GO:0003713 transcription coactivator activity [PMID:10207056]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10207056]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10207056]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:10207056]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10207056]" /note="Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes; turnover is tightly regulated during cell cycle and in response to DNA damage" /db_xref="GeneID:854554" /db_xref="SGD:S000005899" ORIGIN 1 mdrdisyqqn ytstgatats srqpstdnna dtnflkvmse fkynfnsplp tttqfptpys 61 snqyqqtqdh fantdahnss snesslvens ilphhqqiqq qqqqqqqqqq qqqalgslvp 121 pavtrtdtse tlddinvqps svlqfgnslp seflvaspeq fkeflldsps tnfnffhktp 181 aktplrfvtd sngaqqstte npgqqqnvfs nvdlnnllks ngktpsssct gafsrtplsk 241 idmnlmfnqp lptspskrfs slsltpygrk ilndvgtpya kalissnsal vdfqkarkdi 301 ttnatsigle nannilqrtp lrsnnkklfi ktpqdtinst stltkdnenk qdiygssptt 361 iqlnssitks iskldnsrip llasrsdnil dsnvddqlfd lgltrlplsp tpncnslhst 421 ttgtsalqip elpkmgsfrs dtginpisss ntvsfksksg nnnskgrikk ngkkpskfqi 481 ivanidqfnq dtsssslsss lnasssagns nsnvtkkras klkrsqslls dsgsksqark 541 scnsksngnl fnsq // LOCUS NP_015018 851 aa linear PLN 30-JUN-2025 DEFINITION Nud1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015018 VERSION NP_015018.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183793.3 REFERENCE 1 (residues 1 to 851) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 851) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 851) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 851) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 851) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 851) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 851) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 851) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 851) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11132. On Jul 30, 2012 this sequence version replaced NP_015018.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..851 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..851 /product="Nud1p" /calculated_mol_wt="93973" Region <520..802 /region_name="LRR" /note="Leucine-rich repeat (LRR) protein [Transcription]; COG4886" /db_xref="CDD:443914" Region 522..544 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 545..567 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 568..588 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 589..621 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 622..643 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 699..738 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 739..768 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275380" Region 794..806 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" CDS 1..851 /gene="NUD1" /locus_tag="YOR373W" /coded_by="NM_001183793.3:1..2556" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0061499 outer plaque of mitotic spindle pole body [PMID:9585415]" /experiment="EXISTENCE:genetic interaction:GO:0031536 positive regulation of exit from mitosis [PMID:11101520]" /experiment="EXISTENCE:genetic interaction:GO:0051293 establishment of spindle localization [PMID:22385961]" /experiment="EXISTENCE:mutant phenotype:GO:0000073 initial mitotic spindle pole body separation [PMID:22385961]" /experiment="EXISTENCE:mutant phenotype:GO:0030953 astral microtubule organization [PMID:11101520]" /experiment="EXISTENCE:mutant phenotype:GO:0031536 positive regulation of exit from mitosis [PMID:11101520|PMID:23579499]" /experiment="EXISTENCE:mutant phenotype:GO:0035591 signaling adaptor activity [PMID:23579499]" /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:16888627]" /experiment="EXISTENCE:mutant phenotype:GO:0051293 establishment of spindle localization [PMID:22385961]" /experiment="EXISTENCE:physical interaction:GO:0035591 signaling adaptor activity [PMID:23579499]" /note="Mitotic exit network (MEN) scaffold protein; core component of the SPB outer plaque that functions in astral microtubule organization via Spc72p; scaffold for recruitment of MEN components, such as Cdc15p, Tem1p and the Bfa1p-Bub2p checkpoint complex; phosphorylation by Cdc15p creates a Dbf2p-Mob1p phospho-docking site enabling Cdc15p-dependent complex activation and mitotic exit; acts through the MEN to specify Kar9p-mediated asymmetric SPB inheritance; homologous to mammalian centriolin" /db_xref="GeneID:854555" /db_xref="SGD:S000005900" ORIGIN 1 mdmdtqeael ssqlenltin sprklrsnah snsgkvfkey esnhdfqdsn ftsqvvepai 61 sdsvkkpptm tvlnnystvh qkvpsgfsgt tatshqeaqw kqyfpgigsg ggtnfggavg 121 tankvpesdl ivsdlvkdls gvletntfkr hldmknkttt mqthenhdti sishskdffn 181 aekvsssfsd dsdsgpaaea hdvfdgilqk qksnylvgsy psnsnnknnn nnnnnnnnns 241 ininnkdnar tkeedeedts nsfefsssss msssqtqsgr kskvlkkppl ntispgqlgy 301 qfnhthgawd pplnqgldvs sshsldntss nqsqfatmvp tgdnhtngka psildkkaye 361 ltstkpgdvg yrqkkiqeee nlansddtpl dtpkfndlft kngtrakvkg qmrtsrsisn 421 snlleahkkl ktfpaerved itsisevnts fnetekqlis iltsklsgsp sydsdwekil 481 kvdlsrgklk nmfgmqrllp nvlvlnlsdn emntlegips nvvqlfcsnn kitsahcsla 541 gfhdlecldl synllntslk flslchhlqe vnlsynsiqs legigssrmk klnlsnnein 601 giidfeqlil tnnsvvggwl tvevldlsnn niigvrninc lprlkvlnln gnplvsives 661 skmengtlra lsikntggal sklqnykldd qftfpyqnlk ilkldgfaql skwqkwpatl 721 qileinggla sslprfsslk stnlysltia nvrdfthlpv dlskelpflq elhlpgnnlq 781 nahkltktlp rqsvkfldlr nnpittprhd rastslhyrq llqlaglcqq qcpalatlwl 841 ddtpaptatn l // LOCUS NP_015019 519 aa linear PLN 30-JUN-2025 DEFINITION aldehyde dehydrogenase (NADP(+)) ALD4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015019 VERSION NP_015019.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183794.1 REFERENCE 1 (residues 1 to 519) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 519) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 519) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 519) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 519) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11133. Method: conceptual translation. FEATURES Location/Qualifiers source 1..519 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..519 /product="aldehyde dehydrogenase (NADP(+)) ALD4" /EC_number="1.2.1.4" /calculated_mol_wt="56593" Region 42..514 /region_name="ALDH_F1-2_Ald2-like" /note="ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; cd07091" /db_xref="CDD:143410" Site order(188..189,191..192,215,218,247..248,252..253,266..269, 272,275..276,290..292,324,421,423,449,487) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:143410" Site order(192,290,321,324) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:143410" CDS 1..519 /gene="ALD4" /locus_tag="YOR374W" /gene_synonym="ALD7" /coded_by="NM_001183794.1:1..1560" /experiment="EXISTENCE:direct assay:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:9473035]" /experiment="EXISTENCE:direct assay:GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity [PMID:9473035]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11502169|PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0042645 mitochondrial nucleoid [PMID:10869431]" /experiment="EXISTENCE:genetic interaction:GO:0006740 NADPH regeneration [PMID:19158096]" /experiment="EXISTENCE:genetic interaction:GO:0019413 acetate biosynthetic process [PMID:10919763]" /experiment="EXISTENCE:mutant phenotype:GO:0004029 aldehyde dehydrogenase (NAD+) activity [PMID:9675847]" /experiment="EXISTENCE:mutant phenotype:GO:0006067 ethanol metabolic process [PMID:9675847]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:39462103]" /note="Mitochondrial aldehyde dehydrogenase; K+ dependent enzyme that can use either NADP+ or NAD+ as cofactor; required for growth on ethanol and for conversion of acetaldehyde to acetate; can substitute for cytosolic NADP-dependent aldehyde dehydrogenase when directed to the cytosol; influences lipid metabolism; polymerizes into filaments in meiotic cells; phosphorylated; expression is glucose repressed; human homolog ALDH2 can complement a yeast ald4 mutant" /db_xref="GeneID:854556" /db_xref="SGD:S000005901" ORIGIN 1 mfsrstlclk tsassigrlq lryfshlpmt vpiklpngle yeqptglfin nkfvpskqnk 61 tfevinpste eeichiyegr eddveeavqa adrafsngsw ngidpidrgk alyrlaelie 121 qdkdviasie tldngkaiss srgdvdlvin ylkssagfad kidgrmidtg rthfsytkrq 181 plgvcgqiip wnfpllmwaw kiapalvtgn tvvlktaest plsalyvsky ipqagippgv 241 inivsgfgki vgeaitnhpk ikkvaftgst atgrhiyqsa aaglkkvtle lggkspnivf 301 adaelkkavq niilgiyyns gevccagsrv yveesiydkf ieefkaases ikvgdpfdes 361 tfqgaqtsqm qlnkilkyvd igknegatli tggerlgskg yfikptvfgd vkedmrivke 421 eifgpvvtvt kfksadevin mandseygla agihtsnint alkvadrvna gtvwintynd 481 fhhavpfggf nasglgrems vdalqnylqv kavraklde // LOCUS NP_015020 454 aa linear PLN 30-JUN-2025 DEFINITION glutamate dehydrogenase (NADP(+)) GDH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015020 VERSION NP_015020.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183795.3 REFERENCE 1 (residues 1 to 454) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 454) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 454) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 454) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11134. On Jul 30, 2012 this sequence version replaced NP_015020.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..454 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..454 /product="glutamate dehydrogenase (NADP(+)) GDH1" /EC_number="1.4.1.4" /calculated_mol_wt="49439" Region 3..451 /region_name="PRK09414" /note="NADP-specific glutamate dehydrogenase" /db_xref="CDD:181834" CDS 1..454 /gene="GDH1" /locus_tag="YOR375C" /gene_synonym="DHE4; URE1" /coded_by="NM_001183795.3:1..1365" /experiment="EXISTENCE:direct assay:GO:0004354 glutamate dehydrogenase (NADP+) activity [PMID:11562373|PMID:2989290|PMID:2932370]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:4126]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0004354 glutamate dehydrogenase (NADP+) activity [PMID:2989290|PMID:2932370]" /experiment="EXISTENCE:mutant phenotype:GO:0006537 glutamate biosynthetic process [PMID:2932370|PMID:2989290]" /note="NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources; GDH1 has a paralog, GDH3, that arose from the whole genome duplication" /db_xref="GeneID:854557" /db_xref="SGD:S000005902" ORIGIN 1 msepefqqay eevvssleds tlfeqhpeyr kvlpivsvpe riiqfrvtwe ndkgeqevaq 61 gyrvqynsak gpykgglrfh psvnlsilkf lgfeqifkns ltgldmgggk gglcvdlkgr 121 snneirricy afmrelsrhi gqdtdvpagd igvggreigy lfgayrsykn swegvltgkg 181 lnwggslirp eatgyglvyy tqamidyatn gkesfegkrv tisgsgnvaq yaalkvielg 241 gtvvslsdsk gciisetgit seqvadissa kvnfksleqi vneystfsen kvqyiagarp 301 wthvqkvdia lpcatqnevs geeakalvaq gvkfiaegsn mgstpeaiav fetarstatg 361 pseavwygpp kaanlggvav sglemaqnsq ritwtservd qelkriminc fnecidyakk 421 ytkdgkvlps lvkganiasf ikvsdamfdq gdvf // LOCUS NP_878176 51 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR376W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878176 VERSION NP_878176.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184578.1 REFERENCE 1 (residues 1 to 51) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 51) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 51) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 51) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 51) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11135. Method: conceptual translation. FEATURES Location/Qualifiers source 1..51 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..51 /product="uncharacterized protein" /calculated_mol_wt="6083" CDS 1..51 /locus_tag="YOR376W-A" /coded_by="NM_001184578.1:1..156" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466488" /db_xref="SGD:S000028586" ORIGIN 1 mtfhlgwtil wynqaylevw atvfqdemhk yslhpqsrda ktkfcccipf k // LOCUS NP_015022 525 aa linear PLN 30-JUN-2025 DEFINITION alcohol O-acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015022 VERSION NP_015022.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183797.3 REFERENCE 1 (residues 1 to 525) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 525) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 525) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 525) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 525) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11136. On Jul 30, 2012 this sequence version replaced NP_015022.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..525 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..525 /product="alcohol O-acetyltransferase" /EC_number="2.3.1.84" /EC_number="3.1.2.20" /calculated_mol_wt="60905" Region 28..522 /region_name="AATase" /note="Alcohol acetyltransferase; pfam07247" /db_xref="CDD:369286" CDS 1..525 /gene="ATF1" /locus_tag="YOR377W" /coded_by="NM_001183797.3:1..1578" /experiment="EXISTENCE:direct assay:GO:0004026 alcohol O-acetyltransferase activity [PMID:8085822]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:15042596]" /experiment="EXISTENCE:genetic interaction:GO:1901089 acetate ester metabolic process involved in fermentation [PMID:12957907]" /experiment="EXISTENCE:mutant phenotype:GO:1901089 acetate ester metabolic process involved in fermentation [PMID:12957907|PMID:23200656]" /note="Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism" /db_xref="GeneID:854559" /db_xref="SGD:S000005904" ORIGIN 1 mneideknqa pvqqeclkem iqngharrmg svedlyvaln rqnlyrnfct ygelsdyctr 61 dqltlalrei clknptllhi vlptrwpnhe nyyrsseyys rphpvhdyis vlqelklsgv 121 vlneqpeysa vmkqileefk nskgsytaki fkltttltip yfgptgpswr liclpeehte 181 kwkkfifvsn hcmsdgrssi hffhdlrdel nniktppkkl dyifkyeedy qllrklpepi 241 ekvidfrppy lfipksllsg fiynhlrfss kgvcmrmddv ektddvvtei inisptefqa 301 ikaniksniq gkctitpflh vcwfvslhkw gkffkplnfe wltdifipad crsqlpddde 361 mrqmyrygan vgfidftpwi sefdmndnke nfwpliehyh evisealrnk khlhglgfni 421 qgfvqkyvni dkvmcdraig krrggtllsn vglfnqleep dakysicdla fgqfqgswhq 481 afslgvcstn vkgmnivvas tknvvgsqes leelcsiyka lllgp // LOCUS NP_015023 515 aa linear PLN 30-JUN-2025 DEFINITION Amf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015023 VERSION NP_015023.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183798.1 REFERENCE 1 (residues 1 to 515) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 515) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 515) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 515) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 515) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11137. Method: conceptual translation. FEATURES Location/Qualifiers source 1..515 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..515 /product="Amf1p" /calculated_mol_wt="55979" Region 48..493 /region_name="MFS_Amf1_MDR_like" /note="Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; cd17476" /db_xref="CDD:341029" Site order(56..57,60..61,64,97,149..150,152..154,157,178, 181..182,185,313,316..317,320..322,325,356,360,413..414, 418,422,438,441..442,445..446,449) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:341029" CDS 1..515 /gene="AMF1" /locus_tag="YOR378W" /coded_by="NM_001183798.1:1..1548" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:24707045]" /experiment="EXISTENCE:direct assay:GO:0008519 ammonium channel activity [PMID:24707045]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0072488 ammonium transmembrane transport [PMID:24707045]" /note="Low affinity NH4+ transporter; member of the DHA2 family of drug:H+ anti porters; putative paralog of ATR1; but not required for boron tolerance; non-essential gene" /db_xref="GeneID:854560" /db_xref="SGD:S000005905" ORIGIN 1 mstsssvtqk nldtnaealk kedkvlsefd iqderpksll wesafvgvlc saqlmtqagl 61 gqslaplhii gnsfgttnag qlswfasays ltvgtfilia grlgdifghk kffvlgffwy 121 alwsllagfs vysnqiffdc crafqgmgpa fllpnaiail grtykpgrrk nmvfslfgas 181 apggfflgav fssmlgqlaw wpwaywimgi acfvlavagy fviphtpmps rdassfklle 241 ridfagsvtg vvglilfnfa wnqgpvvgwq tpytyalliv gtfflvifay iesraafpll 301 pfaalssdta fvlsciaagw asfgiwifyt wqfmedsrgq tpllssaqfs pvaisgfcaa 361 vttgfllsht ppstvmlfam taftvgtili atapvhqtyw aqtfvsiivm pwgmdmsfpa 421 atimlsdsmp hehqglaasl vntvvnysis iglgiagtie srvndggakp lkgyrcswym 481 giglsglgif vaatyawstf mkskkrisek qhfie // LOCUS NP_015025 546 aa linear PLN 30-JUN-2025 DEFINITION Rdr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015025 VERSION NP_015025.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183800.3 REFERENCE 1 (residues 1 to 546) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 546) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 546) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 546) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11138. On Jul 30, 2012 this sequence version replaced NP_015025.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..546 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..546 /product="Rdr1p" /calculated_mol_wt="61156" Region 14..50 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(15,19,24..27,29,32,41) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(20,23,30,36,39,46) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 158..>334 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..546 /gene="RDR1" /locus_tag="YOR380W" /coded_by="NM_001183800.3:1..1641" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:11882665]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:11882665]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:11882665]" /note="Transcriptional repressor involved in regulating multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins" /db_xref="GeneID:854562" /db_xref="SGD:S000005907" ORIGIN 1 maspgstalp hkrqrvrkac vpcrerkrkc ngkspcemcv aygyvchyid grvpsaspqv 61 qqvgetspdt esrpfvlpgi hrneqpqpin tqnvtsqniv dptksrytiq hsavafprcl 121 glelrstnpp rlhsfawhcg irpeenpnsh vllsdlvtke eyyriskvyf svvhpifdvv 181 npeqlaknve kywdgdvktl eygaviagvi algsffmgsl ghpremdivq yakgilddpt 241 fsriptveqv sawvlrtiyl ratsrphvaw lascvtihls eaiglhheid rediaisnnv 301 ppkrttvvse htrrlfwcaw sintilsydy grssvtlnri tckpvketdg nftahlvala 361 hlipqdsvna naaqllqala avhespnahp flsltkgdic lslyrrlrll nhildknvvl 421 qiidigntal saayalvkld qawwnvlsts fqyvcvllai dtpeslshva tamktldnit 481 qilgtriafe aqktakllle dsmkkkrqei qqleqathqr snletthlld idwdalldps 541 dtlnfm // LOCUS NP_015026 711 aa linear PLN 30-JUN-2025 DEFINITION ferric-chelate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015026 VERSION NP_015026.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183801.1 REFERENCE 1 (residues 1 to 711) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 711) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 711) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 711) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 711) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11139. Method: conceptual translation. FEATURES Location/Qualifiers source 1..711 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..711 /product="ferric-chelate reductase" /EC_number="1.16.1.9" /calculated_mol_wt="80458" Region 280..397 /region_name="Ferric_reduct" /note="Ferric reductase like transmembrane component; pfam01794" /db_xref="CDD:426438" Region 435..709 /region_name="NOX_Duox_like_FAD_NADP" /note="NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; cd06186" /db_xref="CDD:99783" Site order(464,479..482,496..498,502..505,547) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(479,481..482) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99783" Site 542..552 /site_type="other" /note="NAD pyrophosphate binding region [chemical binding]" /db_xref="CDD:99783" Site order(542,546..549,551) /site_type="other" /note="beta-alpha-beta stucture motif" /db_xref="CDD:99783" Site order(547..548,576..578,678..679) /site_type="other" /note="NAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(574..575,578) /site_type="other" /note="NADP ribose binding motif [chemical binding]" /db_xref="CDD:99783" CDS 1..711 /gene="FRE3" /locus_tag="YOR381W" /coded_by="NM_001183801.1:1..2136" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:11120744]" /experiment="EXISTENCE:genetic interaction:GO:0000293 ferric-chelate reductase activity [PMID:11120744]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:10341420|PMID:9726978]" /experiment="EXISTENCE:mutant phenotype:GO:0015891 siderophore transport [PMID:9726978]" /note="Ferric reductase; reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels" /db_xref="GeneID:854563" /db_xref="SGD:S000005908" ORIGIN 1 mywvllcgsi llcclsgasa spaktkmygk lplvltdacm gvlgevtwey ssddlysspa 61 ctyepalqsm lyciyeslne kgysnrtfek tfaaikedca yytdnlqnmt nadfynmlnn 121 gttyiiqyse gsanltypie mdaqvrenyy ysyhgfyany dightyggii cayfvgvmil 181 asilhylsyt pfktalfkqr lvryvrrylt iptiwgkhas sfsylkiftg flptrsegvi 241 ilgylvlhtv flaygyqydp ynlifdsrre qiaryvadrs gvlafahfpl ialfagrnnf 301 lefisgvkyt sfimfhkwlg rmmfldavih gaaytsysvf ykdwaaskee tywqfgvaal 361 civgvmvffs lamfrkffye aflflhivlg alffytcweh vvelsgiewi yaaiaiwtid 421 rlirivrvsy fgfpkaslql vgddiirvtv krpvrlwkak pgqyvfvsfl hhlyfwqshp 481 ftvldsiikd geltiilkek kgvtklvkky vccnggkasm rlaiegpygs sspvnnydnv 541 llltggtglp gpiahaiklg ktsaatgkqf iklviavrgf nvleaykpel mcledlnvql 601 hiyntmevpa ltpndsleis qqdekadgkg vvmattleqs pnpvefdgtv fhhgrpnvek 661 llhevgdlng slavvccgpp vfvdevrdqt anlvlekpak aieyfeeyqs w // LOCUS NP_878177 55 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR381W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878177 VERSION NP_878177.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184579.3 REFERENCE 1 (residues 1 to 55) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 55) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 55) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 55) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11140. On Jul 30, 2012 this sequence version replaced NP_878177.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..55 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..55 /product="uncharacterized protein" /calculated_mol_wt="6570" CDS 1..55 /locus_tag="YOR381W-A" /coded_by="NM_001184579.3:1..168" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466489" /db_xref="SGD:S000028587" ORIGIN 1 mfnvalpsqd kksefykqkr lslrtnilde flrvaktqdn rqnnfvsqyr ndeiy // LOCUS NP_015027 153 aa linear PLN 30-JUN-2025 DEFINITION Fit2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015027 VERSION NP_015027.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183802.1 REFERENCE 1 (residues 1 to 153) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 153) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 153) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 153) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 153) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11141. Method: conceptual translation. FEATURES Location/Qualifiers source 1..153 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..153 /product="Fit2p" /calculated_mol_wt="15171" Region 25..110 /region_name="FIT1_2" /note="Facilitor Of iron transport 1 and 2; pfam17357" /db_xref="CDD:375150" CDS 1..153 /gene="FIT2" /locus_tag="YOR382W" /coded_by="NM_001183802.1:1..462" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0015891 siderophore transport [PMID:12196168]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall" /db_xref="GeneID:854564" /db_xref="SGD:S000005909" ORIGIN 1 mkfstifgat tvmtavsaaa vssvmttkti tatngnnvyt kvvtdtadpi isysttrtvv 61 vsnsdatytk vvtegpdtts eksttktltl tngsgsstnl ytktvtqave sstsssssss 121 sssssasssg aapaafqgas vgalalglis yll // LOCUS NP_015028 204 aa linear PLN 30-JUN-2025 DEFINITION Fit3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015028 VERSION NP_015028.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183803.3 REFERENCE 1 (residues 1 to 204) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 204) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 204) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 204) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 204) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11142. On Jul 30, 2012 this sequence version replaced NP_015028.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..204 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..204 /product="Fit3p" /calculated_mol_wt="19705" CDS 1..204 /gene="FIT3" /locus_tag="YOR383C" /coded_by="NM_001183803.3:1..615" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:direct assay:GO:0015891 siderophore transport [PMID:12196168]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Mannoprotein that is incorporated into the cell wall; incorporated via a glycosylphosphatidylinositol (GPI) anchor; involved in the retention of siderophore-iron in the cell wall" /db_xref="GeneID:854565" /db_xref="SGD:S000005910" ORIGIN 1 mkfssalvls avaatalaes itttitatkn ghvytktvtq datfvwgged syasstsaae 61 ssaaetsaae tsaaattsaa attsaaetss aaetssadeg sgssitttit atknghvytk 121 tvtqdatfvw tgegssntws psststssea atssasttat ttaetsssat ssstaelssy 181 tgaadaitag tglmgaalaa vmll // LOCUS NP_015029 694 aa linear PLN 30-JUN-2025 DEFINITION putative ferric-chelate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015029 VERSION NP_015029.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183804.1 REFERENCE 1 (residues 1 to 694) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 694) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 694) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 694) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11143. Method: conceptual translation. FEATURES Location/Qualifiers source 1..694 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..694 /product="putative ferric-chelate reductase" /EC_number="1.16.1.9" /calculated_mol_wt="80162" Region 274..391 /region_name="Ferric_reduct" /note="Ferric reductase like transmembrane component; pfam01794" /db_xref="CDD:426438" Region 429..601 /region_name="NOX_Duox_like_FAD_NADP" /note="NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX...; cd06186" /db_xref="CDD:99783" Site order(458,473..476,490..492,496..499,541) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99783" Site order(473,475..476) /site_type="other" /note="FAD binding motif [chemical binding]" /db_xref="CDD:99783" Region 531..673 /region_name="NAD_binding_6" /note="Ferric reductase NAD binding domain; pfam08030" /db_xref="CDD:429792" Site 536..546 /site_type="other" /note="NAD pyrophosphate binding region [chemical binding]" /db_xref="CDD:99783" Site order(536,540..543,545) /site_type="other" /note="beta-alpha-beta stucture motif" /db_xref="CDD:99783" Site order(569..570,573) /site_type="other" /note="NADP ribose binding motif [chemical binding]" /db_xref="CDD:99783" CDS 1..694 /gene="FRE5" /locus_tag="YOR384W" /coded_by="NM_001183804.1:1..2085" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:854566" /db_xref="SGD:S000005911" ORIGIN 1 mlfarlvlll vylapgslak pastkkrtqw dqiaidacak eleshkfdtd vkgrhatlct 61 yepalgswlh cakdvldsrk kskkifektf skinqychdy hkdevvsnee yyrifanasl 121 firpldevke nirypvtpnk asldrwvway fgpldnidkg nvygvticly wigvlfiaav 181 yhflnfsrlk qtvfknkvsa flrghyvlpa lvhnhamsvg rwffiglvpt rletlvlfgy 241 vllhgfllss ynfdhnells drrsqvlifl sdragilafa hfplivlfgg knstmtwltg 301 irytafityh kwlgrfmlvd ctihaigyty hayienywky vkysdlwtsg rhamiivgil 361 vffsffffrr hyyelfvith iilaigffha cwkhcyklgw gewimacalf wiadrilrli 421 kiaifgmpwa klklcgesmi evrisksskw wkaepgqyiy lyflrpkifw qshpftvmds 481 lvedgelvvv itvkngltkk lqeylleseg ytemrvlaeg pygqstrthl fesllfiagg 541 agvpgplsma ikagrqvksn dshqmikfvw svrnldllev yrkeimvlke lnidtkiyft 601 gerkdesnte egaianmste grllttsksa emitdfgrpn ideiieeavs gaksllvtcc 661 gsegfvdktr eltakrvleh gdkwieyvee fqnw // LOCUS NP_015030 290 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR385W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015030 VERSION NP_015030.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183805.3 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11144. On Jul 30, 2012 this sequence version replaced NP_015030.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..290 /product="uncharacterized protein" /calculated_mol_wt="33933" CDS 1..290 /locus_tag="YOR385W" /coded_by="NM_001183805.3:1..873" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene" /db_xref="GeneID:854567" /db_xref="SGD:S000005912" ORIGIN 1 mrgfsgqpls dddnyriekt qrntiperlh fsrernmpia sifgtrgyfv fsseqsydkf 61 kqtnfnistl dadgvgvplf hivqsynvig kitrsspdfy iykyvlqgvq dpplysdckv 121 icqdkvfrlc kilyceiyah qgffetkydf fypsktqpvk kyqiikqsnm rdlystldgm 181 rfrwhvkfys dhfrlmflde drlnysnsnq kerqkpdqgk skapdfvigh ytrtfsdilp 241 rstskcsnli igehskpdsl gittvpdltq efacqgalih yllhiererk // LOCUS NP_015031 565 aa linear PLN 30-JUN-2025 DEFINITION deoxyribodipyrimidine photo-lyase PHR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015031 VERSION NP_015031.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183806.1 REFERENCE 1 (residues 1 to 565) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 565) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 565) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 565) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 565) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11145. Method: conceptual translation. FEATURES Location/Qualifiers source 1..565 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..565 /product="deoxyribodipyrimidine photo-lyase PHR1" /EC_number="4.1.99.3" /calculated_mol_wt="66143" Region 75..564 /region_name="PhrB" /note="Deoxyribodipyrimidine photolyase [Replication, recombination and repair]; COG0415" /db_xref="CDD:440184" CDS 1..565 /gene="PHR1" /locus_tag="YOR386W" /coded_by="NM_001183806.1:1..1698" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:21124907]" /experiment="EXISTENCE:direct assay:GO:0003904 deoxyribodipyrimidine photo-lyase activity [PMID:2911265]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /note="DNA photolyase involved in photoreactivation; repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p" /db_xref="GeneID:854568" /db_xref="SGD:S000005913" ORIGIN 1 mkrtvisssn ayaskrsrld iehdfeqyhs lnkkyyprpi trtganqfnn ksrakpmeiv 61 eklqkkqkts fenvstvmhw frndlrlydn vglyksvalf qqlrqknaka klyavyvine 121 ddwrahmdsg wklmfimgal knlqqslael hiplllwefh tpkstlsnsk efveffkekc 181 mnvssgtgti itanieyqtd elyrdirlle nedhrlqlky yhdscivapg littdrgtny 241 svftpwykkw vlyvnnykks tseichlhii eplkynetfe lkpfqyslpd eflqyipksk 301 wclpdvseea alsrlkdflg tksskynnek dmlylggtsg lsvyittgri strlivnqaf 361 qscngqimsk alkdnsstqn fikevawrdf yrhcmcnwpy tsmgmpyrld tldikwennp 421 vafekwctgn tgipivdaim rkllytgyin nrsrmitasf lsknllidwr wgerwfmkhl 481 idgdsssnvg gwgfcsstgi daqpyfrvfn mdiqakkydp qmifvkqwvp elissenkrp 541 enypkplvdl khsreralkv ykdam // LOCUS NP_015032 206 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR387C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015032 VERSION NP_015032.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183807.3 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11146. On Jul 30, 2012 this sequence version replaced NP_015032.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..206 /product="uncharacterized protein" /calculated_mol_wt="22009" Region 6..205 /region_name="Vel1p" /note="Yeast-specific zinc responsive; pfam10339" /db_xref="CDD:402107" CDS 1..206 /locus_tag="YOR387C" /coded_by="NM_001183807.3:1..621" /note="hypothetical protein; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively; YOR387C has a paralog, VEL1, that arose from a single-locus duplication" /db_xref="GeneID:854569" /db_xref="SGD:S000005914" ORIGIN 1 msflniftff svlvsvatav rfdltnvtcn nlhgphcgty vmevvgqngt flgqstfaga 61 dvltesagda warylgqetr flpklttias ndtknfspli fttniytcnp qsigdamvpf 121 antvtgeiey nswadtadna sfitglanql fnstqygvqv ascypnfasv ilstptvnif 181 aanetlpdyc taiqlkavcp pdagfa // LOCUS NP_015033 376 aa linear PLN 30-JUN-2025 DEFINITION formate dehydrogenase (NAD+) [Saccharomyces cerevisiae S288C]. ACCESSION NP_015033 VERSION NP_015033.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183808.1 REFERENCE 1 (residues 1 to 376) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 376) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 376) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 376) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 376) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11147. Method: conceptual translation. FEATURES Location/Qualifiers source 1..376 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..376 /product="formate dehydrogenase (NAD+)" /EC_number="1.17.1.9" /calculated_mol_wt="41583" Region 4..371 /region_name="FDH" /note="NAD-dependent Formate Dehydrogenase (FDH); cd05302" /db_xref="CDD:240627" Site order(11..13,23,123..124,127..128,130..131,134..135,138, 140..141,143..148,150..159,161..165,167,183..184,187..188, 298,301..303,305,310..311,320..327,329..332,334,336) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:240627" Site order(73,97,121..122,125,173,175..177,197..199,242..244, 246,249,270..272,296..297,325,327..328) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:240627" CDS 1..376 /gene="FDH1" /locus_tag="YOR388C" /coded_by="NM_001183808.1:1..1131" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11921099]" /experiment="EXISTENCE:direct assay:GO:0008863 formate dehydrogenase (NAD+) activity [PMID:21246355]" /experiment="EXISTENCE:genetic interaction:GO:0042183 formate catabolic process [PMID:19564482]" /note="NAD(+)-dependent formate dehydrogenase; may protect cells from exogenous formate" /db_xref="GeneID:854570" /db_xref="SGD:S000005915" ORIGIN 1 mskgkvllvl yeggkhaeeq ekllgciene lgirnfieeq gyelvttidk dpeptstvdr 61 elkdaeivit tpffpayisr nriaeapnlk lcvtagvgsd hvdleaaner kitvtevtgs 121 nvvsvaehvm atilvlirny ngghqqaing ewdiagvakn eydledkiis tvgagrigyr 181 vlerlvafnp kkllyydyqe lpaeainrln easklfngrg divqrvekle dmvaqsdvvt 241 incplhkdsr glfnkklish mkdgaylvnt argaicvaed vaeavksgkl agyggdvwdk 301 qpapkdhpwr tmdnkdhvgn amtvhisgts ldaqkryaqg vknilnsyfs kkfdyrpqdi 361 ivqngsyatr aygqkk // LOCUS NP_015034 624 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR389W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015034 VERSION NP_015034.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183809.3 REFERENCE 1 (residues 1 to 624) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 624) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 624) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 624) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 624) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11148. On Jul 30, 2012 this sequence version replaced NP_015034.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..624 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..624 /product="uncharacterized protein" /calculated_mol_wt="70090" CDS 1..624 /locus_tag="YOR389W" /coded_by="NM_001183809.3:1..1875" /note="hypothetical protein; expression regulated by copper levels" /db_xref="GeneID:854571" /db_xref="SGD:S000005916" ORIGIN 1 mrfhrqgtaa tvgvllivll gfcwklsesy givstalphk qpatkitdtp sirwdnyhef 61 vrdidfdnst aifnsiraal rqspsdihpv gvsyfpavip kgtlmyhags kvpttfewla 121 mdhefsysfg lrspsygrks lerrhgrfgn gthgdhpkgp ppppppdekd rgsqkmltyr 181 aardlnkfly ldgasaaktd sgemdtqlml snvikeklnl tddgenerma erlyaarick 241 wgkpfgldgi irvevgfevv lcdfsadnve lvsmlemvqp nqylglpapt viskeegwpl 301 dengnlvedq ltddqkaile redgwektfs nfnavksfnq lragtahdng ehrihidyry 361 lvsginrtyi apdpnnrrll degmtwekql dmvddlekal evgfdatqsm dwqlafdelv 421 lkfapllksv snilnsngdi nesiainata ltlnfclrfe pasnnsdefg sgkdfavyqy 481 vspyqalktd adfliwssav svvgeivdai ykvndllipe vysfmtdntt ssdliknvet 541 arstidglie slgwielnyr cerqcnwdev cytpswgpsp mgmtepgshn egfgthfdes 601 rqrlvinskl qcinindlmv nrnh // LOCUS NP_015035 375 aa linear PLN 30-JUN-2025 DEFINITION fluoride transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_015035 VERSION NP_015035.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183810.1 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11149. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..375 /product="fluoride transporter" /calculated_mol_wt="41854" Region <53..>104 /region_name="CRCB" /note="CrcB-like protein, Camphor Resistance (CrcB); pfam02537" /db_xref="CDD:460582" Region 243..359 /region_name="CRCB" /note="CrcB-like protein, Camphor Resistance (CrcB); pfam02537" /db_xref="CDD:460582" CDS 1..375 /gene="FEX1" /locus_tag="YOR390W" /coded_by="NM_001183810.1:1..1128" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:26055717]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:1903424 fluoride transmembrane transport [PMID:26055717|PMID:24173035]" /experiment="EXISTENCE:genetic interaction:GO:1903425 fluoride transmembrane transporter activity [PMID:24173035]" /experiment="EXISTENCE:mutant phenotype:GO:1903424 fluoride transmembrane transport [PMID:26055717]" /note="Protein involved in fluoride export; nearly identical to FEX2, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins" /db_xref="GeneID:854572" /db_xref="SGD:S000005917" ORIGIN 1 mifnpvisnh klshyihvfc tfttfcilgt etrqaitals tytpafvtap tvlwsncssc 61 mlmgimqsln aytwmkdhqv lflgvttgyc galssfssml lemfehstnl tngnianhtk 121 lpnraygime flsvllvhlm vsmgslifgr qlgkevivay gsssfskpyt ppsdtvkena 181 gdvdtqemek nilefkfktp apffkkffdi vdklayalaf pliilfvvlc ayyenysrgk 241 wtlpclfgif agflrywlae mfnktnkkfp lgtflanvfa tlligiftmv qrgkkhfstd 301 vpivnslnsc hivsalisgf cgtlstistf inegyklsfi nmliyytvsi aisycllvit 361 lgsyawtrgl tnpic // LOCUS NP_015036 237 aa linear PLN 30-JUN-2025 DEFINITION glutathione-independent methylglyoxalase family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_015036 VERSION NP_015036.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183811.3 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11150. On Jul 30, 2012 this sequence version replaced NP_015036.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..237 /product="glutathione-independent methylglyoxalase family protein" /EC_number="4.2.1.130" /calculated_mol_wt="25795" Region 5..235 /region_name="GAT_1" /note="Type 1 glutamine amidotransferase (GATase1)-like domain; cl00020" /db_xref="CDD:469582" Site 138 /site_type="active" /note="conserved cys residue [active]" /db_xref="CDD:153241" CDS 1..237 /gene="HSP33" /locus_tag="YOR391C" /coded_by="NM_001183811.3:1..714" /experiment="EXISTENCE:mutant phenotype:GO:0031669 cellular response to nutrient levels [PMID:24706893]" /note="Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer" /db_xref="GeneID:854573" /db_xref="SGD:S000005918" ORIGIN 1 mtpkralisl tsyhgpfykd gaktgvfvve ilrsfdtfek hgfevdfvse tggfgwdehy 61 lpksfigged kmnfetknsa fnkalarikt anevnasdyk vffasaghga lfdypkaknl 121 qdiaskiyan ggviaaichg pllfdglidi kttrpliegk aitgfplege ialgvddilr 181 srklttverv ankngakyla pihpwddysi tdgklvtgvn anssysttir ainalys // LOCUS NP_015038 437 aa linear PLN 30-JUN-2025 DEFINITION phosphopyruvate hydratase ERR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015038 VERSION NP_015038.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183813.1 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11151. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..437 /product="phosphopyruvate hydratase ERR1" /EC_number="4.2.1.11" /calculated_mol_wt="47197" Region 1..428 /region_name="PTZ00081" /note="enolase; Provisional" /db_xref="CDD:240259" CDS 1..437 /gene="ERR1" /locus_tag="YOR393W" /coded_by="NM_001183813.1:1..1314" /note="Putative phosphopyruvate hydratase" /db_xref="GeneID:854575" /db_xref="SGD:S000005920" ORIGIN 1 msitkvhart vydsrgnptv eveittengl fraivpsgas tgiheavelr dgnksewmgk 61 gvtkavsnvn siigpaliks elcvtnqkgi delmisldgt snksrlgana ilgvslcvar 121 aaaaqkgitl ykyiaelada rqdpfvipvp ffnvlnggah aggslamqef kiapvgaqsf 181 aeamrmgsev yhhlkilake qygpsagnvg deggvapdid taedaldmiv eainicgyeg 241 rvkvgidsap svfykdgkyd lnfkepnsdp shwlspaqla eyyhsllkky piisledpya 301 eddwsswsaf lktvnvqiia ddltctnktr iaraieekca ntlllklnqi gtltesieaa 361 nqafdagwgv mishrsgete dpfiadlvvg lrcgqiksga lsrserlaky nellrieeel 421 gddciyaghr fhdgnkl // LOCUS NP_015039 164 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU21 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015039 VERSION NP_015039.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183814.3 REFERENCE 1 (residues 1 to 164) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 164) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 164) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 164) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11152. On Jul 30, 2012 this sequence version replaced NP_015039.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..164 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..164 /product="seripauperin PAU21" /calculated_mol_wt="17583" Region 66..158 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..164 /gene="PAU21" /locus_tag="YOR394W" /coded_by="NM_001183814.3:1..495" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP, seamless-GFP and mCherry fusion proteins localize to the cytosol; identical to Pau22p; encodes two proteins that are translated from 2 different start codons" /db_xref="GeneID:854576" /db_xref="SGD:S000005921" ORIGIN 1 mtnegiginr dtsticlrey vfihffpvkl isaltnktnt mvkltsiaag vaaiaagvaa 61 apatttlsps dervnlvelg vyvsdirahl aqyylfqaah ptetypveia eavfnygdft 121 tmltgipaeq vtrvitgvpw ystrlrpais salskdgiyt aipk // LOCUS NP_878178 55 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR394C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878178 VERSION NP_878178.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184626.1 REFERENCE 1 (residues 1 to 55) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 55) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 55) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 55) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 55) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11153. Method: conceptual translation. FEATURES Location/Qualifiers source 1..55 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..55 /product="uncharacterized protein" /calculated_mol_wt="6180" CDS 1..55 /locus_tag="YOR394C-A" /coded_by="NM_001184626.1:1..168" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466490" /db_xref="SGD:S000028718" ORIGIN 1 mivnnthilt lpphavstlt ciliwhrhtd atvyiissyp tltfhsmahl slhqy // LOCUS NP_061495 1796 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase protein 1 copy 8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_061495 VERSION NP_061495.4 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184447.3 REFERENCE 1 (residues 1 to 1796) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1796) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 1796) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1796) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 1796) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11154. On Jul 30, 2012 this sequence version replaced NP_061495.3. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1796 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..1796 /product="Y' element ATP-dependent helicase protein 1 copy 8" /EC_number="3.6.4.12" /calculated_mol_wt="203651" Region <13..88 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 790..962 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" Region 1037..1132 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1796 /gene="YRF1-8" /locus_tag="YOR396W" /coded_by="NM_001184447.3:1..5391" /note="One of several telomeric Y' element-encoded DNA helicases; known as Y'-Help1 (Y'-HELicase Protein 1)" /db_xref="GeneID:854577" /db_xref="SGD:S000007526" ORIGIN 1 mkvsdrrkfe kanfdefesa lnnkndlvhc psitlfesip tevrsfyede ksglikvvkf 61 rtgamdrkrs fekivisvmv gknvqkfltf vedepdfqgg pipskylipk kinlmvytlf 121 qvhtlkfnrk dydtlslfyl nrgyynelsf rvlercheia sarpndsstm rtftdfvsga 181 pivrslqkst irkygynlap ymflllhvde lsifsayqas lpgekkvdte rlkrdlcprk 241 pieikyfsqi cndmmnkkdr lgdilhiilr acalnfgagp rggagdeedr sitneepiip 301 svdehglkvc klrspntprr lrktldavka llvsscacta rdldifddtn gvamwkwiki 361 lyhevaqett lkdsyritlv pssdgisvcg klfnreyvrg fyfackaqfd nlwgelnncf 421 ymptvvdias lilrnrevlf repkrgidey lendsflqmi pvkyreivlp klrrdtnkmt 481 aalknkvtva ideltvplmw mvhfavgypy rypelqllaf agpqrnvyvd dttrriqlyt 541 dynkngssep rlktldglts dyvfyfvtvl rqmqicalgn sydafnhdpw mdvvgfedpd 601 qvtnrdisri vlysymflnt akgclveyat frqymrelpk napqklnfre mrqglialgr 661 hcvgsrfetd lyesatselm anhsvqtgrn iygvdsfslt svsgttatll qeraserwiq 721 wlglesdyhc sfsstrnaed vvageaassd hdqkisrvtr krprepkstn dilvagqklf 781 gssfefrdlh qlrlcheiym adtpsvavqa ppgygktelf hlplialask gdvkyvsflf 841 vpytvllanc mirlsrcgcl nvapvrnfie egcdgvtdly vgiyddlast nftdriaawe 901 nivectfrtn nvklgylivd efhnfetevy rqsqfggitn ldfdafekai flsgtapeav 961 adaalqrigl tglakksmdi nelkrsedls rglssyptrm fnlikeksev plghvhkiwk 1021 kvesqpeeal klllalfeie peskaivvas ttneveelac swrkyfrvvw ihgklgaaek 1081 vsrtkefvtd gsmrvligtk lvtegidikq lmmvimldnr lniieliqgv grlrdgglcy 1141 llsrknswaa rnrkgelppi kegciteqvr efygleskkg kkgqhvgccg srtdlsadtv 1201 eliermdrla ekqatasmsi ialpssfqes nssdrcrkyc ssdedsdtci hgsanastna 1261 ttnsstnatt tastnvrtsa tttasinvrt saittestns stnatttast nvrtsattta 1321 sinvrtsatt testnsntsa tttestdsnt satttestds ntsatttast nsstnattta 1381 stnsstnatt testnasake dankdgnaed nrfhpvtdin kesykrkgsq mvllerkklk 1441 aqfpntsenm nvlqflgfrs deikhlflyg idvyfcpegv ftqyglckgc qkmfelcvcw 1501 agqkvsyrrm awealaverm lrndeeykey lediepyhgd pvgylkyfsv krgeiysqiq 1561 rnyawylait rrretisvld strgkqgsqv frmsgrqike lyykvwsnlr esktevlqyf 1621 lnwdekkcre eweakddtvf vealekvgvf qrlrsmtsag lqgpqyvklq fsrhhrqlrs 1681 ryelslgmhl rdqlalgvtp skvphwtafl smliglfynk tfrqkleyll eqisevwllp 1741 hwldlanvev laadntrvpl ymlmvavhke ldsddvpdgr fdiillcrds srevge // LOCUS NP_001335818 109 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR314W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335818 VERSION NP_001335818.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348880.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80338. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..109 /product="uncharacterized protein" /calculated_mol_wt="12392" CDS 1..109 /locus_tag="YOR314W" /coded_by="NM_001348880.1:1..330" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:854491" /db_xref="SGD:S000005841" ORIGIN 1 mtmirfcgar qsaiisnasd aaagtnkkri lnpleslcln dridehrcke vqlsslrsll 61 yamilnrtig setgvfsfll fsfryfgeer dlfycffsvf llnitylld // LOCUS NP_001335819 108 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR343C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335819 VERSION NP_001335819.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348881.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80339. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..108 /product="uncharacterized protein" /calculated_mol_wt="12045" CDS 1..108 /locus_tag="YOR343C" /coded_by="NM_001348881.1:1..327" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:854521" /db_xref="SGD:S000005870" ORIGIN 1 mehtahifpi iikgsppvms snprrqyrln lrsikclkep rvrvwqaqwp lepalsaakm 61 praahahaph afeiqasvpa glqgsgyfap svrsdlrlpr sflflnkk // LOCUS NP_001335820 122 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YOR376W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335820 VERSION NP_001335820.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348882.1 REFERENCE 1 (residues 1 to 122) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 122) AUTHORS Dujon,B., Albermann,K., Aldea,M., Alexandraki,D., Ansorge,W., Arino,J., Benes,V., Bohn,C., Bolotin-Fukuhara,M., Bordonne,R., Boyer,J., Camasses,A., Casamayor,A., Casas,C., Cheret,G., Cziepluch,C., Daignan-Fornier,B., Dang,D.V., de Haan,M., Delius,H., Durand,P., Fairhead,C., Feldmann,H., Gaillon,L., Kleine,K. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XV JOURNAL Nature 387 (6632 SUPPL), 98-102 (1997) PUBMED 9169874 REFERENCE 3 (residues 1 to 122) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 122) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (04-MAY-2012) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 7 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 8 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (27-MAY-2010) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 9 (residues 1 to 122) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80340. Method: conceptual translation. FEATURES Location/Qualifiers source 1..122 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XV" Protein 1..122 /product="uncharacterized protein" /calculated_mol_wt="13669" CDS 1..122 /locus_tag="YOR376W" /coded_by="NM_001348882.1:1..369" /note="hypothetical protein; conserved among S. cerevisiae strains; YOR376W is not an essential gene" /db_xref="GeneID:854558" /db_xref="SGD:S000005903" ORIGIN 1 mknrkfsnll llrlrilcfn kkpafaatsy afffrnfsvl ifimvpdeke ngaaadnsfs 61 lligrgvvlf lfycptalkm hgpvpahwfc dknieaiqsd gqirllrsgp fpwshgtcir 121 ga // LOCUS NP_015040 1859 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase protein 1 copy 7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015040 VERSION NP_015040.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184097.1 REFERENCE 1 (residues 1 to 1859) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1859) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1859) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1859) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1859) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11155. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1859 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1859 /product="Y' element ATP-dependent helicase protein 1 copy 7" /EC_number="3.6.4.12" /calculated_mol_wt="210985" Region 38..152 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" Region 854..1026 /region_name="DEAD" /note="DEAD/DEAH box helicase; pfam00270" /db_xref="CDD:425570" Region 1101..1196 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1859 /gene="YRF1-7" /locus_tag="YPL283C" /gene_synonym="YRF1" /coded_by="NM_001184097.1:1..5580" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0000722 telomere maintenance via recombination [PMID:9837911]" /note="Helicase encoded by the Y' element of subtelomeric regions; highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p" /db_xref="GeneID:855846" /db_xref="SGD:S000006204" ORIGIN 1 meieneqict ciaqilhlln sliitflddd ktetgqsfvy idgflvkkhn nqhtivnfet 61 yknkmkvsdr rkfekanfde fesalnnknd lvhcpsitlf esiptevrsf yedeksglik 121 vvkfrtgamd rkrsfekivv svmvgknvqk fltfvedepd fqggpipsky lipkkinlmv 181 ytlfqvhtlk fnrkdydtls lfylnrgyyn elsfrvlerc yeiasarpnd sstmrtftdf 241 vsgtpivrgl qkstirkygy nlapymflll hvdelsifsa yqaslpgekk vdterlkrdl 301 cprkpteiky fsqicndmmn kkdrlgdilh iilracalnf gagprggagd eedrsitnee 361 piipsvdehg lkvcklrspn tprrlrktld avkallvssc actardldif ddnngvamwk 421 wikilyheva qetalkdsyr itlvpssdgv svcgklfnre yvrgfyfack aqfdnlweel 481 ndcfymptvv diaslilrnr evlfrepkrg ideylendsf lqmipvkyre ivlpklrrdt 541 nkmtaalknk vtvaideltv plmwmihfav gypyrypelq llafagpqrn vyvddttrri 601 qlytdynkng sseprlktld gltsdyvfyf vtvlrqmqic algnsydafn hdpwmdvvgf 661 edpdqvtnrd isrivlysym flntakgclv eyatfrqymr elpknapqkl nfremrqgli 721 algrhcvgsr fetdlyesat selmanhsvq tgrniygvds fsltsvsgtt atllqerase 781 rwiqwlgles dyhcsfsstr naedvvagea assdhhqkis rvtrkrprep kstndilvag 841 qklfgssfef rdlhqlrlch eiymadtpsv avqappgygk telfhlplia laskgdvkyv 901 sflfvpytvl lancmirlsr cgclnvapvr nfieegcdgv tdlyvgiydd lastnftdri 961 aawenivect frtnnvklgy livdefhnfe tevyrqsqfg gitnldfdaf ekaiflsgta 1021 peavadaalq rigltglakk smdinelkrs edlsrglssy ptrmfnlike ksevplghvh 1081 kiwkkvesqp eealklllal feiepeskai vvasttneve elacswrkyf rvvwihgklg 1141 aaekvsrtke fvtdgsmrvl igtklvtegi dikqlmmvim ldnrlniiel iqgvgrlrdg 1201 glcyllsrkn swaarnrkge lppikegcit eqvrefygle skkgkkgqhv gccgsrtdls 1261 adtvelierm drlaekqata smsivalpss fqesnssdrc rkycssdeds dtcihgsana 1321 stnattnsst natttastnv rtsatttasi nvrtsattte stnsstnatt tastnvrtsa 1381 tttasinvrt satttestns ntsatttest dsntsattte stdsntsatt tastnsstna 1441 tttastnsst natttestna sakedankdg naednrfhpv tdinkesykr kgsqmvller 1501 kklkaqfpnt senmnvlqfl gfrsdeikhl flygidvyfc pegvftqygl ckgcqkmfel 1561 cvcwagqkvs yrrmaweala vermlrndee ykeylediep yhgdpvgylk yfsvkrgeiy 1621 sqiqrnyawy laitrrreti svldstrgkq gsqvfrmsgr qikelyykvw snlresktev 1681 lqyflnwdek kcreeweakd dtvfvealek vgvfqrlrsm tsaglqgpqy vklqfsrhhr 1741 qlrsryelsl gmhlrdqlal gvtpskvphw taflsmligl fcnktfrqkl eylleqisev 1801 wllphwldla nvevlaadnt rvplymlmva vhkeldsddv pdgrfdillc rdssrevge // LOCUS NP_015041 164 aa linear PLN 30-JUN-2025 DEFINITION seripauperin PAU22 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015041 VERSION NP_015041.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184096.1 REFERENCE 1 (residues 1 to 164) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 164) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 164) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 164) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11156. Method: conceptual translation. FEATURES Location/Qualifiers source 1..164 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..164 /product="seripauperin PAU22" /calculated_mol_wt="17583" Region 66..158 /region_name="SRP1_TIP1" /note="Seripauperin and TIP1 family; pfam00660" /db_xref="CDD:395534" CDS 1..164 /gene="PAU22" /locus_tag="YPL282C" /coded_by="NM_001184096.1:1..495" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="hypothetical protein; member of the seripauperin multigene family encoded mainly in subtelomeric regions; SWAT-GFP fusion protein localizes to the endoplasmic reticulum and vacuole, while mCherry fusion localizes to just the vacuole; identical to Pau21p; encodes two proteins that are translated from two different start codons" /db_xref="GeneID:855847" /db_xref="SGD:S000006203" ORIGIN 1 mtnegiginr dtsticlrey vfihffpvkl isaltnktnt mvkltsiaag vaaiaagvaa 61 apatttlsps dervnlvelg vyvsdirahl aqyylfqaah ptetypveia eavfnygdft 121 tmltgipaeq vtrvitgvpw ystrlrpais salskdgiyt aipk // LOCUS NP_015042 437 aa linear PLN 30-JUN-2025 DEFINITION phosphopyruvate hydratase ERR2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015042 VERSION NP_015042.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184095.1 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11157. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..437 /product="phosphopyruvate hydratase ERR2" /EC_number="4.2.1.11" /calculated_mol_wt="47197" Region 1..428 /region_name="PTZ00081" /note="enolase; Provisional" /db_xref="CDD:240259" CDS 1..437 /gene="ERR2" /locus_tag="YPL281C" /coded_by="NM_001184095.1:1..1314" /experiment="EXISTENCE:direct assay:GO:0004634 phosphopyruvate hydratase activity [PMID:23359425]" /experiment="EXISTENCE:genetic interaction:GO:0004634 phosphopyruvate hydratase activity [PMID:23359425]" /note="Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant" /db_xref="GeneID:855848" /db_xref="SGD:S000006202" ORIGIN 1 msitkvhart vydsrgnptv eveittengl fraivpsgas tgiheavelr dgnksewmgk 61 gvtkavsnvn siigpaliks elcvtnqkgi delmisldgt snksrlgana ilgvslcvar 121 aaaaqkgitl ykyiaelada rqdpfvipvp ffnvlnggah aggslamqef kiapvgaqsf 181 aeamrmgsev yhhlkilake qygpsagnvg deggvapdid taedaldmiv eainicgyeg 241 rvkvgidsap svfykdgkyd lnfkepnsdp shwlspaqla eyyhsllkky piisledpya 301 eddwsswsaf lktvnvqiia ddltctnktr iaraieekca ntlllklnqi gtltesieaa 361 nqafdagwgv mishrsgete dpfiadlvvg lrcgqiksga lsrserlaky nellrieeel 421 gddciyaghr fhdgnkl // LOCUS NP_015043 237 aa linear PLN 30-JUN-2025 DEFINITION glutathione-independent methylglyoxalase family protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_015043 VERSION NP_015043.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184094.1 REFERENCE 1 (residues 1 to 237) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 237) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 237) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 237) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 237) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11158. Method: conceptual translation. FEATURES Location/Qualifiers source 1..237 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..237 /product="glutathione-independent methylglyoxalase family protein" /EC_number="4.2.1.130" /calculated_mol_wt="25809" Region 5..235 /region_name="GAT_1" /note="Type 1 glutamine amidotransferase (GATase1)-like domain; cl00020" /db_xref="CDD:469582" Site 138 /site_type="active" /note="conserved cys residue [active]" /db_xref="CDD:153222" CDS 1..237 /gene="HSP32" /locus_tag="YPL280W" /coded_by="NM_001184094.1:1..714" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:24706893]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:24706893|PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0051596 methylglyoxal catabolic process [PMID:27984092]" /experiment="EXISTENCE:mutant phenotype:GO:0031669 cellular response to nutrient levels [PMID:24706893]" /note="Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer" /db_xref="GeneID:855849" /db_xref="SGD:S000006201" ORIGIN 1 mtpkralisl tsyhgpfykd gaktgvfvve ilrsfdtfek hgfevdfvse tggfgwdehy 61 lpksfigged kmnfetknsa fnkalarikt anevnasdyk iffasaghga lfdypkaknl 121 qdiaskiyan ggviaaichg pllfdglidi kttrpliegk aitgfplege ialgvddilr 181 srklttverv ankngakyla pihpwddysi tdgklvtgvn anssysttir ainalys // LOCUS NP_015044 375 aa linear PLN 30-JUN-2025 DEFINITION fluoride transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_015044 VERSION NP_015044.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184093.1 REFERENCE 1 (residues 1 to 375) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 375) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 375) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 375) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 375) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11159. Method: conceptual translation. FEATURES Location/Qualifiers source 1..375 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..375 /product="fluoride transporter" /calculated_mol_wt="41840" Region <53..>104 /region_name="CRCB" /note="CrcB-like protein, Camphor Resistance (CrcB); pfam02537" /db_xref="CDD:460582" Region 243..359 /region_name="CRCB" /note="CrcB-like protein, Camphor Resistance (CrcB); pfam02537" /db_xref="CDD:460582" CDS 1..375 /gene="FEX2" /locus_tag="YPL279C" /coded_by="NM_001184093.1:1..1128" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:26055717]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:1903424 fluoride transmembrane transport [PMID:24173035|PMID:26055717]" /experiment="EXISTENCE:genetic interaction:GO:1903425 fluoride transmembrane transporter activity [PMID:24173035]" /experiment="EXISTENCE:mutant phenotype:GO:1903424 fluoride transmembrane transport [PMID:26055717]" /note="Protein involved in fluoride export; nearly identical to FEX1, and deletion of both proteins results in a large increase in fluoride sensitivity compared with the single mutant; contains two FEX domains connected by a linker; part of a widespread family of conserved fluoride export proteins" /db_xref="GeneID:855850" /db_xref="SGD:S000006200" ORIGIN 1 mifnpvisnh klshyihvfc tfttfcilgt etrqaitals tytpafvtap tvlwsncssc 61 mlmgimqsln aytwmkdhqv lflgvttgyc galssfssml lemfehstnl tngnianhtk 121 lpnraygime flsvllvhlm vsmgslifgr qlgkevivay gsssfskpyt ppsdtvkena 181 gdvdtqemek nilefkfktp apffkkffdv vdklayalaf pliilfvvlc ayyenysrgk 241 wtlpclfgif agflrywlae mfnktnkkfp lgtflanvfa tlligiftmv qrgkkhfstd 301 ipivnslnsc hivsalisgf cgtlstistf inegyklsfi nmliyytvsi gisycllvit 361 lgsyawtrgl tnpic // LOCUS NP_015045 100 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL278C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015045 VERSION NP_015045.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184092.1 REFERENCE 1 (residues 1 to 100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 100) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11160. Method: conceptual translation. FEATURES Location/Qualifiers source 1..100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..100 /product="uncharacterized protein" /calculated_mol_wt="11290" CDS 1..100 /locus_tag="YPL278C" /coded_by="NM_001184092.1:1..303" /note="hypothetical protein; gene expression regulated by copper levels" /db_xref="GeneID:855851" /db_xref="SGD:S000006199" ORIGIN 1 mtdnttssdl iknvetarst idglieslgw ielnyrcerq cnwdevcytp swgpspmgmt 61 epgshnegfg thfdesrqrl vinsklqcin indlmvnrnh // LOCUS NP_015046 487 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL277C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015046 VERSION NP_015046.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184091.1 REFERENCE 1 (residues 1 to 487) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 487) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 487) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 487) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 487) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11161. Method: conceptual translation. FEATURES Location/Qualifiers source 1..487 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..487 /product="uncharacterized protein" /calculated_mol_wt="54407" CDS 1..487 /locus_tag="YPL277C" /coded_by="NM_001184091.1:1..1464" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11935221]" /note="hypothetical protein; localized to the membranes; gene expression regulated by copper levels" /db_xref="GeneID:855852" /db_xref="SGD:S000006198" ORIGIN 1 mrfhrqgisa iigvllivll gfcwklsgsy givstalphn qsaikstdlp sirwdnyhef 61 vrdidfdnst aifnsiraal rqspsdihpv gvsyfpavip kgtlmyhags kvpttfewla 121 mdhefsysfg lrspsygrks lerrhgrfgn gtngdhpkgp pppppppdek grgsqkmlty 181 raardlnkfl yldgasaakt dsgemdtqlm lsnvikekln ltddgenerm aerlyaaric 241 kwgkpfgldg iirvevgfev vlcdfsadnv elvsmlemvq pnqylglpap tviskeegwp 301 ldengslved qltddqkail eredgwekaf snfnavksfn qlragaahdn gehrihidyr 361 ylvsginrty iapdpnnrrl ldegmtwekq ldmvddleka levgfdatqs mdwqlafdel 421 vlkfapllks vsnilnsdgd inesiainat altlnfclpi cepipglkng crlfdlvicc 481 qrcrrnc // LOCUS NP_015049 587 aa linear PLN 30-JUN-2025 DEFINITION bifunctional polyamine/amino acid permease SAM3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015049 VERSION NP_015049.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184088.1 REFERENCE 1 (residues 1 to 587) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 587) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 587) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 587) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 587) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11162. Method: conceptual translation. FEATURES Location/Qualifiers source 1..587 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..587 /product="bifunctional polyamine/amino acid permease SAM3" /calculated_mol_wt="64223" Region 74..551 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..587 /gene="SAM3" /locus_tag="YPL274W" /coded_by="NM_001184088.1:1..1764" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015489 putrescine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015606 spermidine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015847 putrescine transport [PMID:17218313]" /experiment="EXISTENCE:direct assay:GO:0015848 spermidine transport [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity [PMID:10497160]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:10497160]" /experiment="EXISTENCE:mutant phenotype:GO:0015489 putrescine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0015606 spermidine transmembrane transporter activity [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0015805 S-adenosyl-L-methionine transport [PMID:10497160]" /experiment="EXISTENCE:mutant phenotype:GO:0015847 putrescine transport [PMID:17218313]" /experiment="EXISTENCE:mutant phenotype:GO:0015848 spermidine transport [PMID:17218313]" /note="High-affinity S-adenosylmethionine permease; required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p" /db_xref="GeneID:855854" /db_xref="SGD:S000006195" ORIGIN 1 mdilkrgnes dkftkietes ttipndsdrs gslirrmkds fkqsnlhvip edlenseqte 61 qekiqwklas qpyqkvlsqr hltmiaiggt lgtglfiglg yslasgpaal ligfllvgts 121 mfcvvqsaae lscqfpvsgs yathvsrfid esvgftvatn yalawlisfp seligcalti 181 sywnqtvnpa vwvaifyvfi mvlnlfgvrg faetefalsi ikviaififi iigivliagg 241 gpnstgyiga kywhdpgafa kpvfknlcnt fvsaafsfgg selvlltste sknisaisra 301 akgtfwriai fyittvviig clvpyndprl lsgsnsedvs aspfvialsn tgsmgakvsn 361 fmnvvilvav vsvcnscvya ssrliqalga sgqlpsvcsy mdrkgrplvg igisgafgll 421 gflvaskked evftwlfalc sissfftwfc icmsqirfrm alkaqgrsnd eiayksilgv 481 yggilgcvln alliageiyv saapvgspss aeaffeycls ipimivvyfa hrfyrrdwkh 541 fyikrseidl dtgcsvenle lfkaqkeaee qliaskpfyy kiyrfwc // LOCUS NP_015050 325 aa linear PLN 30-JUN-2025 DEFINITION S-adenosylmethionine-homocysteine S-methyltransferase SAM4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015050 VERSION NP_015050.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184087.1 REFERENCE 1 (residues 1 to 325) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 325) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 325) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 325) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11163. Method: conceptual translation. FEATURES Location/Qualifiers source 1..325 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..325 /product="S-adenosylmethionine-homocysteine S-methyltransferase SAM4" /EC_number="2.1.1.10" /calculated_mol_wt="36538" Region 18..321 /region_name="S-methyl_trans" /note="Homocysteine S-methyltransferase; pfam02574" /db_xref="CDD:460598" CDS 1..325 /gene="SAM4" /locus_tag="YPL273W" /coded_by="NM_001184087.1:1..978" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity [PMID:11013242]" /experiment="EXISTENCE:direct assay:GO:0019284 L-methionine salvage from S-adenosylmethionine [PMID:14189892]" /experiment="EXISTENCE:direct assay:GO:0033353 S-adenosylmethionine cycle [PMID:14189892]" /experiment="EXISTENCE:direct assay:GO:0050667 homocysteine metabolic process [PMID:14189892]" /note="S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog, YMR321C, that arose from a single-locus duplication" /db_xref="GeneID:855855" /db_xref="SGD:S000006194" ORIGIN 1 marlplkqfl adnpkkvlvl dggqgtelen rgikvanpvw stipfisesf wsdessanrk 61 ivkemfndfl nagaeilmtt tyqtsyksvs entpirtlse ynnllnrivd fsrncigedk 121 yligcigpwg ahicreftgd ygaepenidf yqyfkpqlen fnkndkldli gfetipnihe 181 lkailswdes ilsrpfyigl svhehgvlrd gttmeeiaqv ikdlgdkinp nfsflgincv 241 sfnqspdile slhqalpnma llaypnsgev ydtekkiwlp nsdklnswdt vvkqyissga 301 riiggccrts pkdiqeisaa vkkyt // LOCUS NP_015051 517 aa linear PLN 30-JUN-2025 DEFINITION Pbi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015051 VERSION NP_015051.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184086.1 REFERENCE 1 (residues 1 to 517) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 517) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 517) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 517) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 517) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11164. Method: conceptual translation. FEATURES Location/Qualifiers source 1..517 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..517 /product="Pbi1p" /calculated_mol_wt="59258" Region 32..>279 /region_name="Condensation" /note="Condensation domain; cl23853" /db_xref="CDD:420054" CDS 1..517 /gene="PBI1" /locus_tag="YPL272C" /coded_by="NM_001184086.1:1..1554" /note="hypothetical protein; gene expression induced in response to ketoconazole; YPL272C is not an essential gene" /db_xref="GeneID:855856" /db_xref="SGD:S000006193" ORIGIN 1 mttfrplssf ekkiltqsln dqrngtifss tyskslsren dadwhsdevt lgtnsskdds 61 rltlpliatt lkrliksqpa lfatvneewe feplkqlkts divnviefet ikdkevnchw 121 gvpppyllrh afnktrfvpg snkplwtlyv ideallvfhg hdvlfdifsa anfhklflke 181 lneistvths edrilfdvnd inlselkfpk siydsaklhl pamtpqifhk qtqsffksiy 241 yntlkrpfgy ltnqtslsss vsatqlkkyn dilnahtslc gttvfgivnn qrfnylksiv 301 nqehiclrsf icgiamiclk plvkdfsgti vftipinlrn hlglggslgl ffkelrvecp 361 lsliddelsa nefltnsndn ednddefner lmeyqfnkvt khvsgfimak lrswekngfn 421 dddirrmkyd ndddfhiqns rtkliqindv sdislsmngd dksfkivstg ftssinrptl 481 mslsytycee mglnicihyp dsynlesfve cfesfie // LOCUS NP_015052 62 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit epsilon [Saccharomyces cerevisiae S288C]. ACCESSION NP_015052 VERSION NP_015052.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184085.1 REFERENCE 1 (residues 1 to 62) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 62) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 62) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 62) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 62) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11165. Method: conceptual translation. FEATURES Location/Qualifiers source 1..62 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..62 /product="F1F0 ATP synthase subunit epsilon" /calculated_mol_wt="6611" Region 2..51 /region_name="ATP-synt_Eps" /note="Mitochondrial ATP synthase epsilon chain; pfam04627" /db_xref="CDD:461373" Site order(4..5,9..12,15..16,20,38..48) /site_type="other" /note="gamma subunit interface [polypeptide binding]" /db_xref="CDD:213396" Site order(11,14..19,24..27,30,38) /site_type="other" /note="delta subunit interface [polypeptide binding]" /db_xref="CDD:213396" CDS 1..62 /gene="ATP15" /locus_tag="YPL271W" /coded_by="NM_001184085.1:1..189" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:15294286|PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0045259 proton-transporting ATP synthase complex [PMID:15294286|PMID:17082766]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:8416924]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:8416924]" /experiment="EXISTENCE:mutant phenotype:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:8416924]" /note="Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated" /db_xref="GeneID:855857" /db_xref="SGD:S000006192" ORIGIN 1 msawrkagis yaaylnvaaq airsslktel qtasvlnrsq tdafytqykn gtaaseptpi 61 tk // LOCUS NP_015053 773 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette permease MDL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015053 VERSION NP_015053.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184084.1 REFERENCE 1 (residues 1 to 773) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 773) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 773) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 773) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 773) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 773) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 773) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11166. On Oct 2, 2003 this sequence version replaced NP_015053.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..773 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..773 /product="ATP-binding cassette permease MDL2" /calculated_mol_wt="85006" Region 1..685 /region_name="3a01208" /note="Conjugate Transporter-2 (CT2) Family protein; TIGR00958" /db_xref="CDD:273363" CDS 1..773 /gene="MDL2" /locus_tag="YPL270W" /coded_by="NM_001184084.1:1..2322" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11251115]" /note="Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis" /db_xref="GeneID:855858" /db_xref="SGD:S000006191" ORIGIN 1 mlngrlpllr lgicrnmlsr prlaklpsir frslvtpsss qliplsrlcl rspavgksli 61 lqsfrcnssk tvpetslpsa spiskgsars ahakeqsktd dykdiirlfm lakrdwklll 121 taillltisc sigmsipkvi givldtlkts sgsdffdlki pifslplyef lsfftvalli 181 gcaanfgrfi llrilservv arlranvikk tlhqdaeffd nhkvgdlisr lgsdayvvsr 241 smtqkvsdgv kalicgvvgv gmmcslspql silllfftpp vlfsasvfgk qirntskdlq 301 eatgqltrva eeqlsgiktv qsfvaegnel srynvairdi fqvgktaaft nakfftttsl 361 lgdlsfltvl aygsylvlqs qlsigdltaf mlyteytgna vfglstfyse imqgagaasr 421 lfeltdrkps isptvghkyk pdrgviefkd vsfsyptrps vqifknlnfk iapgssvciv 481 gpsgrgksti allllryynp ttgtitidnq disklncksl rrhigivqqe pvlmsgtird 541 nitygltytp tkeeirsvak qcfchnfitk fpntydtvig phgtllsggq kqriaiaral 601 ikkptilild eatsaldves egainytfgq lmksksmtiv siahrlstir rsenvivlgh 661 dgsvvemgkf kelyanptsa lsqllnekaa pgpsdqqlqi ekviekedln eskehddqkk 721 ddnddndnnh dndsnnqspe tkdnnsddie ksvehllkda akeanpikit pqp // LOCUS NP_015054 644 aa linear PLN 30-JUN-2025 DEFINITION Kar9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015054 VERSION NP_015054.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184083.1 REFERENCE 1 (residues 1 to 644) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 644) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 644) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 644) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 644) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11167. Method: conceptual translation. FEATURES Location/Qualifiers source 1..644 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..644 /product="Kar9p" /calculated_mol_wt="74114" Region 84..>406 /region_name="KAR9" /note="Yeast cortical protein KAR9; pfam08580" /db_xref="CDD:430088" CDS 1..644 /gene="KAR9" /locus_tag="YPL269W" /coded_by="NM_001184083.1:1..1935" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:20534809]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:26906737]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:9442113]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:9442113]" /experiment="EXISTENCE:genetic interaction:GO:0031578 mitotic spindle orientation checkpoint signaling [PMID:24850890]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:9442113]" /experiment="EXISTENCE:mutant phenotype:GO:0051293 establishment of spindle localization [PMID:22385961]" /note="Spindle positioning factor; orients astral microtubules, connecting them to actin cables at the cortex with Bim1p and Myo2, resulting in proper spindle positioning; targeted for StuBL-dependent degradation at kinetochores by Slx5p-Slx8p, ensuring chromosome transmission fidelity and correct spindle positioning; role in karyogamy; localizes to the shmoo tip, the growing bud-tip, the nucleus, the kinetochore, the spindle and microtubules; homolog of adenomatous polyposis coli" /db_xref="GeneID:855859" /db_xref="SGD:S000006190" ORIGIN 1 mdndgprsmt igddfqenfc erlerihntl hsindcnsln esttsisetl lvqfyddlen 61 vasvipdlvn kkrlgkddil lfmdwlllkk ymlyqfisdv hnieegfahl ldlledefsk 121 ddqdsdkynr fspmfdviee stqiktqlep wltnlkelld tslefneisk dhmdtlhkii 181 nsnisyclei qeerfaspir htpsftleql vkllgthtet tepkvpkfsp aedilsrkfl 241 nlkknippie ksltdilpqr ivqfghrnit nittlqtilq kkyelimkdy rfmnsefrel 301 kvelidkrwn ilfinlnhel lyildeierl qskllttkyt kditirlerq lerksktvsk 361 tfniiyrale fslldagvas ktnelaqrwl nikptadkil ikssasnkia tskkkipkpk 421 slgfgrpnsv igtitqdfqe rvainegdsn ktpensttva lkgkklgkal lqkmnikpat 481 spnssnainp ffdpespnkg klilssvppl pydetdettl rvsrgeneks pdsfitsrhe 541 nkvqitetpl maknksvldi ekdkwnhyrs lpsripiykd kvvkvtvent piakvfqtpp 601 tkittpnsqv wvpstrrrtr lrpptplsql lspregrldk tpty // LOCUS NP_015055 869 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol phospholipase C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015055 VERSION NP_015055.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184082.1 REFERENCE 1 (residues 1 to 869) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 869) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 869) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 869) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 869) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11168. Method: conceptual translation. FEATURES Location/Qualifiers source 1..869 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..869 /product="phosphatidylinositol phospholipase C" /EC_number="3.1.4.11" /calculated_mol_wt="100417" Region 124..224 /region_name="PH_PLC_fungal" /note="Fungal Phospholipase C (PLC) pleckstrin homology (PH) domain; cd13360" /db_xref="CDD:241514" Region 233..368 /region_name="EFh_ScPlc1p_like" /note="EF-hand motif found in Saccharomyces cerevisiae phospholipase C-1 (ScPlc1p) and similar proteins; cd16207" /db_xref="CDD:320037" Region 233..266 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320037" Region 273..302 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320037" Region 306..335 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320037" Region 343..368 /region_name="EF-hand motif" /note="EF-hand motif [structural motif]" /db_xref="CDD:320037" Region 364..857 /region_name="PLN02228" /note="Phosphoinositide phospholipase C" /db_xref="CDD:177873" Region 379..688 /region_name="PI-PLC1c_yeast" /note="Catalytic domain of putative yeast phosphatidylinositide-specific phospholipases C; cd08598" /db_xref="CDD:176540" Site order(395..396,425,427,439,472,518,520,614,643,645) /site_type="active" /note="putative active site [active]" /db_xref="CDD:176540" Site order(395,439) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:176540" Site order(396,425,427,472) /site_type="other" /note="putative Ca binding site [ion binding]" /db_xref="CDD:176540" CDS 1..869 /gene="PLC1" /locus_tag="YPL268W" /coded_by="NM_001184082.1:1..2610" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:10779349|PMID:12756538]" /experiment="EXISTENCE:direct assay:GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity [PMID:15485855|PMID:8395015]" /experiment="EXISTENCE:direct assay:GO:0009395 phospholipid catabolic process [PMID:8395015]" /experiment="EXISTENCE:genetic interaction:GO:0001402 signal transduction involved in filamentous growth [PMID:10514491]" /experiment="EXISTENCE:mutant phenotype:GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity [PMID:9784626|PMID:7753023]" /experiment="EXISTENCE:mutant phenotype:GO:0009395 phospholipid catabolic process [PMID:7753023]" /experiment="EXISTENCE:mutant phenotype:GO:0032958 inositol phosphate biosynthetic process [PMID:10390371]" /experiment="EXISTENCE:mutant phenotype:GO:0034501 protein localization to kinetochore [PMID:19205744]" /experiment="EXISTENCE:physical interaction:GO:0000776 kinetochore [PMID:10779349]" /experiment="EXISTENCE:physical interaction:GO:0001402 signal transduction involved in filamentous growth [PMID:10514491]" /note="Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation" /db_xref="GeneID:855860" /db_xref="SGD:S000006189" ORIGIN 1 mtesaiddqr fnltkelqrh scrdqgkitq kddaldfisy ssfqssfntd qksanngstv 61 rrsirsifrr aaelprvhmg pltyshgine lvnkklrkdc dlstlcrvlq rgirmirmtr 121 rrrkfyefkl innngqiiwk dgskylelds vkdirigdta styqeevdpk rlrsdsklwi 181 aiiykvsnkl kalhvvalne ldfntflsci cglvklrrel mesillpdns qfarihwqit 241 vsekeedekk dtlsfadvkk lcdkfhiyvs tgqlleffql adinhnglln yfefekfiki 301 lknrkevnmi wskftkpphs hlsfenffqf liteqheqvd rqtawsyfik yreptqltmg 361 qdgftkflke qpylvevkee lyskplnhyf iasshntyll gkqiaetpsv egyiqvlqqg 421 crcveidiwd gengpvvchg fltsaiplkt virvikkyaf itspypliis leincnkdnq 481 klaslimrev laeqlyfvgt rtdklpspre lkhkillksk ktseatrgls vnepfpssfs 541 ssyesaneqe lrmkddstns ssatnsssmq rikriglkkh adiindvsni sgihgikfrn 601 fslpesktia hcfslnerkv eymikdkhlk lsldkhnrry lmrvyphvlr ykssnfnpip 661 fwkagvqmva tnwqtndigq qlnlamfqil dhqpdgsfks gyvlkpkkll pvvtkakmip 721 liyehfengs dpvtvkiril stqllprlnd tspsrnntns fvkvefhtdd eptmpisidk 781 gtrisateas tkssqgngfn piwdaevsit lkdtdltfik fmviseetqi asvclklnyl 841 rmgyrhiplf nmegeqyifc tlfihtqil // LOCUS NP_015056 209 aa linear PLN 30-JUN-2025 DEFINITION Acm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015056 VERSION NP_015056.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184081.1 REFERENCE 1 (residues 1 to 209) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 209) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 209) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 209) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11169. Method: conceptual translation. FEATURES Location/Qualifiers source 1..209 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..209 /product="Acm1p" /calculated_mol_wt="23739" Region 61..128 /region_name="Acm1_CIR" /note="CIR (central inhibitory region) domain of Saccharomyces cerevisiae APC/C-CDH1 modulator 1 (Acm1) and similar proteins; cd22876" /db_xref="CDD:467853" Site order(61..66,71,74..75,78,81..82,84..91,93..94,98..103,105, 115..116,119..125) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467853" CDS 1..209 /gene="ACM1" /locus_tag="YPL267W" /coded_by="NM_001184081.1:1..630" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18498748]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:18498748]" /experiment="EXISTENCE:direct assay:GO:0031397 negative regulation of protein ubiquitination [PMID:18519589|PMID:18596038]" /experiment="EXISTENCE:direct assay:GO:0055105 ubiquitin-protein transferase inhibitor activity [PMID:18596038|PMID:18498748|PMID:18519589]" /experiment="EXISTENCE:genetic interaction:GO:0055105 ubiquitin-protein transferase inhibitor activity [PMID:18498748]" /experiment="EXISTENCE:mutant phenotype:GO:0055105 ubiquitin-protein transferase inhibitor activity [PMID:18596038|PMID:18498748]" /note="Pseudosubstrate inhibitor of the APC/C; suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein; the anaphase-promoting complex/cyclosome is also known as APC/C" /db_xref="GeneID:855861" /db_xref="SGD:S000006188" ORIGIN 1 mispskkrti lsskninqkp ravvkgnelr spskrrsqid tdyalrrspi ktiqiskaaq 61 fmlyeetaee rniavhrhne iynnnnsvsn ennpsqvken lspakicpye raflreggri 121 alkdlsvdef kgyiqdpltd etipltlplg dkkislpsfi tpprnskisi fftskhqgqn 181 petkisrstd dvsekkvvrk lsfhvyede // LOCUS NP_015057 318 aa linear PLN 30-JUN-2025 DEFINITION putative dimethyladenosine transferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015057 VERSION NP_015057.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184080.1 REFERENCE 1 (residues 1 to 318) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 318) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 318) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 318) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 318) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11170. Method: conceptual translation. FEATURES Location/Qualifiers source 1..318 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..318 /product="putative dimethyladenosine transferase" /EC_number="2.1.1.183" /calculated_mol_wt="35820" Region 28..317 /region_name="AdoMet_MTases" /note="S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); cl17173" /db_xref="CDD:473071" Site order(63..69,85..86,112..114,128) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..318 /gene="DIM1" /locus_tag="YPL266W" /gene_synonym="CDH1" /coded_by="NM_001184080.1:1..957" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:mutant phenotype:GO:0000154 rRNA modification [PMID:8064863]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8064863]" /note="Essential 18S rRNA dimethylase (dimethyladenosine transferase); responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing; human homolog DIMT1 complements yeast dim1 mutant" /db_xref="GeneID:855862" /db_xref="SGD:S000006187" ORIGIN 1 mgkaakkkys gatsskqvsa ekhlssvfkf ntdlgqhilk nplvaqgivd kaqirpsdvv 61 levgpgtgnl tvrileqakn vvavemdprm aaeltkrvrg tpvekkleim lgdfmktelp 121 yfdicisntp yqissplvfk linqprpprv silmfqrefa lrllarpgds lycrlsanvq 181 mwanvthimk vgknnfrppp qvessvvrle iknprpqvdy newdgllriv fvrknrtisa 241 gfksttvmdi leknyktfla mnnemvddtk gsmhdvvkek idtvlketdl gdkragkcdq 301 ndflrllyaf hqvgihfs // LOCUS NP_015058 608 aa linear PLN 30-JUN-2025 DEFINITION dicarboxylic amino acid permease [Saccharomyces cerevisiae S288C]. ACCESSION NP_015058 VERSION NP_015058.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184079.1 REFERENCE 1 (residues 1 to 608) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 608) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 608) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 608) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 608) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11171. Method: conceptual translation. FEATURES Location/Qualifiers source 1..608 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..608 /product="dicarboxylic amino acid permease" /calculated_mol_wt="67967" Region 83..566 /region_name="2A0310" /note="amino acid permease (yeast); TIGR00913" /db_xref="CDD:273334" CDS 1..608 /gene="DIP5" /locus_tag="YPL265W" /coded_by="NM_001184079.1:1..1827" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005310 dicarboxylic acid transmembrane transporter activity [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0006865 amino acid transport [PMID:10654085]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Dicarboxylic amino acid permease; mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly; relocalizes from plasma membrane to vacuole upon DNA replication stress" /db_xref="GeneID:855863" /db_xref="SGD:S000006186" ORIGIN 1 mkmplkkmft stsprnsssl dsdhdayysk qnpdnfpvke qeiynidlee nnvssrssts 61 tspsarddsf avpdgkdent rlrkdlkarh ismiaiggsl gtglligtgt alltggpvam 121 liayafvgll vfytmaclge masyipldgf tsyasryvdp algfaigyty lfkyfilppn 181 qltaaalviq ywisrdrvnp gvwitiflvv ivainvvgvk ffgefefwls sfkvmvmlgl 241 illlfiimlg ggpnhdrlgf rywrdpgafk eystaitggk gkfvsfvavf vyslfsytgi 301 eltgivcsea enprksvpka ikltvyriiv fylctvfllg mcvayndprl lstkgksmsa 361 aaspfvvaiq nsgievlphi fnacvlvfvf sacnsdlyvs srnlyalaid gkapkifakt 421 srwgvpynal ilsvlfcgla ymnvssgsak ifnyfvnvvs mfgilswiti livyiyfdka 481 craqgidksk fayvapgqry gayfalffci lialiknftv flghkfdykt fitgyiglpv 541 yiiswagykl iyktkvikst dvdlytfkei ydreeeegrm kdqekeerlk sngknmewfy 601 ekflgnif // LOCUS NP_015059 353 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL264C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015059 VERSION NP_015059.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184078.1 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11172. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..353 /product="uncharacterized protein" /calculated_mol_wt="39572" Region 16..324 /region_name="RhaT" /note="Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]; COG0697" /db_xref="CDD:440461" CDS 1..353 /locus_tag="YPL264C" /coded_by="NM_001184078.1:1..1062" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:31945465]" /note="Endoplasmic reticulum hypothetical protein; physically interacts with Hsp82p; YPL264C is not an essential gene" /db_xref="GeneID:855864" /db_xref="SGD:S000006185" ORIGIN 1 mtlqriskdy lkpnyglill ivsyffnssm vvstkvlend pletsqsrin plqillvrms 61 itycctlvym hwnkqsvpdi pwgpapcrkw lilrgimgff gvfgmyfslm ylsisdavli 121 tfmsptltif lsflllgepf sklealgsli sfsgvvliir ptflfgeqtq gqqspqddiv 181 etqnpklrli aigvsllgvc glssvyiiir yignkahaim svsyfslvtt vvaalgvlli 241 psmslqlphs wkqwglflnl gisgfihqil ltmgiqrera grgslmtytq viyavfwdvv 301 lfhhwpniwt wcgmavivss tiwvinmras kqnvvatael lstsdfeldd led // LOCUS NP_015060 651 aa linear PLN 30-JUN-2025 DEFINITION Kel3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015060 VERSION NP_015060.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184077.1 REFERENCE 1 (residues 1 to 651) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 651) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 651) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 651) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 651) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11173. Method: conceptual translation. FEATURES Location/Qualifiers source 1..651 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..651 /product="Kel3p" /calculated_mol_wt="75302" Region <79..268 /region_name="NanM" /note="N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis]; COG3055" /db_xref="CDD:442289" Region 138..194 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 197..242 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 250..308 /region_name="Kelch_4" /note="Galactose oxidase, central domain; pfam13418" /db_xref="CDD:433191" Region 251..308 /region_name="KELCH repeat" /note="KELCH repeat [structural motif]" /db_xref="CDD:276965" Region 315..371 /region_name="Kelch_4" /note="Galactose oxidase, central domain; pfam13418" /db_xref="CDD:433191" Region 564..651 /region_name="DUF4110" /note="Domain of unknown function (DUF4110); pfam13422" /db_xref="CDD:463871" CDS 1..651 /gene="KEL3" /locus_tag="YPL263C" /coded_by="NM_001184077.1:1..1956" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic hypothetical protein" /db_xref="GeneID:855865" /db_xref="SGD:S000006184" ORIGIN 1 makknkkdke akkaraelkn qknqkkqekk fqknknksln geeddesdqd ldeilssfsk 61 kqielehvdi tsvekpscrt hplmfanpqh nkhelfifgg eftdpetklt hfyndlysys 121 iknnswkkyv sqnaplprss aavavhpsgi allhggefss pkqskfyhys dtwlfdcver 181 kftklefggr dsspsarsgh riiawknyfi lfggfrdlgn gqtsylndlw cfdistykwt 241 kletnskpda rsghcfiptd nsailmggyc kiiaknnknl mkgkilndaw klnltpdpkk 301 wqweklknfk nqpsprvgys fnlwkqnksv afggvydlqe teeslesvfy ndlymfhlel 361 nkwsklrikp qrqtnsknsp atskrksnkd qekelqdlln silaksnlnd ddddnddnst 421 tgpnsiddde dneddsdldn qeditisnql phprfnaatc vvgdslfiys gvwelgekdy 481 pinsfysidl nkldgvkvyw edlsaieeak rlgdrdsded efeyeddeed eddgeeeqda 541 gplegdedee sesdddkqaq meipderswl phpkpfetlr afylreganf ltwsisnnrn 601 lkgkqlktks felcedrwwe rrdqvtleee rledtggiie rdtttkpskr r // LOCUS NP_015061 488 aa linear PLN 30-JUN-2025 DEFINITION fumarase FUM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015061 VERSION NP_015061.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184076.1 REFERENCE 1 (residues 1 to 488) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 488) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 488) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 488) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 488) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 488) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 488) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11174. Method: conceptual translation. FEATURES Location/Qualifiers source 1..488 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..488 /product="fumarase FUM1" /EC_number="4.2.1.2" /calculated_mol_wt="53021" Region 26..486 /region_name="FumC" /note="Fumarate hydratase class II [Energy production and conversion]; COG0114" /db_xref="CDD:439884" CDS 1..488 /gene="FUM1" /locus_tag="YPL262W" /coded_by="NM_001184076.1:1..1467" /experiment="EXISTENCE:direct assay:GO:0004333 fumarate hydratase activity [PMID:3040736]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:20231875]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:11502169]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11585823]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11585823]" /experiment="EXISTENCE:mutant phenotype:GO:0006099 tricarboxylic acid cycle [PMID:1587456]" /experiment="EXISTENCE:mutant phenotype:GO:0006106 fumarate metabolic process [PMID:1587456]" /note="Fumarase; converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria" /db_xref="GeneID:855866" /db_xref="SGD:S000006183" ORIGIN 1 mlrftncsck tfvkssykln irrmnssfrt etdafgeihv padkywgaqt qrsfqnfkig 61 garermplpl vhafgvlkks aaivneslgg ldpkiskaiq qaadevasgk lddhfplvvf 121 qtgsgtqsnm nanevisnra ieilggkigs kqvhpnnhcn qsqssndtfp tvmhiaaslq 181 iqnelipelt nlknaleaks kefdhivkig rthlqdatpl tlgqefsgyv qqvengiqrv 241 ahslktlsfl aqggtavgtg lntkpgfdvk iaeqisketg lkfqtapnkf ealaahdaiv 301 ecsgalntla cslfkiaqdi rylgsgprcg yhelmlpene pgssimpgkv nptqnealtq 361 vcvqvmgnna aitfagsqgq felnvfkpvm ianllnsirl itdaaysfrv hcvegikane 421 prihelltks lmlvtalnpk igydaaskva knahkkgitl kesalelgvl tekefdewvv 481 pehmlgpk // LOCUS NP_001335821 102 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL261C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335821 VERSION NP_001335821.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348883.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80341. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..102 /product="uncharacterized protein" /calculated_mol_wt="11710" CDS 1..102 /locus_tag="YPL261C" /coded_by="NM_001348883.1:1..309" /note="hypothetical protein; conserved among S. cerevisiae strains; YPL261C is not an essential gene; partially overlaps verified ORF YPL260W" /db_xref="GeneID:855868" /db_xref="SGD:S000006182" ORIGIN 1 mlfldsysll iqfqrfknwe sprrfsssfp lllfvfkpif aakllkeics sgvlsyslsf 61 lkiplsvmrv ilgplpddkk lkndakysfm nyfiitcigi im // LOCUS NP_015063 551 aa linear PLN 30-JUN-2025 DEFINITION Cub1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015063 VERSION NP_015063.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184074.1 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11175. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..551 /product="Cub1p" /calculated_mol_wt="62649" Region 209..372 /region_name="DUF2408" /note="Protein of unknown function (DUF2408); pfam10303" /db_xref="CDD:431205" Region 341..443 /region_name="DUF2408" /note="Protein of unknown function (DUF2408); pfam10303" /db_xref="CDD:431205" Region 428..>518 /region_name="DUF2408" /note="Protein of unknown function (DUF2408); pfam10303" /db_xref="CDD:431205" CDS 1..551 /gene="CUB1" /locus_tag="YPL260W" /coded_by="NM_001184074.1:1..1656" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Conserved fungal gene linked to DNA repair and proteasome function; putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855867" /db_xref="SGD:S000006181" ORIGIN 1 mfasagqqhp qivpkeeesi lnyllevrss laklkqnrtq ylnskdvqtt yqhvltkvre 61 lddirknshe tpaksaatli hstelhnrvd svlddvfqll slcfltvglk nsapatyasl 121 stvesllehl nesnvfthhd lspikerlee iskiveqkns spaydedgnd drlreidner 181 kknkieedll lraklkhckd eydilegkle eidpslstvm eklfrirrgl lslvasakkt 241 msksdintns llqeqndlqt nnesltddkh lvsqeyvhek lsvlknelse lesnrddsgk 301 fksleshqva ekgqsvlngl lddchdlvnd lshqkngglt ldpylqpiye qlidikttle 361 nlmitrrwtl retdlfsyqk klneidnkri ngkfptksqd skgqsillyl lrrcyaiiyk 421 llessepvse alqpihnqls tvrrcllelk rmggvnnere lypyqmklas ldnlrtegif 481 ydsdgnipeg qgilnallae cfdilhelkv eaeekaqnst ssdgsddddn gesgidsnsn 541 dsepeseyqq e // LOCUS NP_015064 475 aa linear PLN 30-JUN-2025 DEFINITION Apm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015064 VERSION NP_015064.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184073.1 REFERENCE 1 (residues 1 to 475) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 475) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 475) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 475) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 475) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11176. Method: conceptual translation. FEATURES Location/Qualifiers source 1..475 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..475 /product="Apm1p" /calculated_mol_wt="53743" Region 3..143 /region_name="AP1_Mu_N" /note="AP-1 complex subunit mu N-terminal domain; cd14835" /db_xref="CDD:341439" Site order(18,21,44..45,47..48,56,58,60,73..79,82,86,112..113, 116..117,119..121,123..126,135,137..138) /site_type="other" /note="AP-1 beta interface [polypeptide binding]" /db_xref="CDD:341439" Region 161..471 /region_name="AP-1_Mu1_Cterm" /note="C-terminal domain of medium Mu1 subunit in clathrin-associated adaptor protein (AP) complex AP-1; cd09250" /db_xref="CDD:271158" Site order(173,193,195,197..198,208,218,273,276,300,307,309,323, 335,337,343,348,367,372,375..376,385,391..392,394,429..431, 434,443..446,456..460,465,467..468) /site_type="other" /note="heterotetramer interface [polypeptide binding]" /db_xref="CDD:271158" Site order(179..181,208,347,431,433,458..461,463) /site_type="signal peptide" /note="signal peptide binding site [polypeptide binding]" /db_xref="CDD:271158" CDS 1..475 /gene="APM1" /locus_tag="YPL259C" /gene_synonym="YAP54" /coded_by="NM_001184073.1:1..1428" /experiment="EXISTENCE:direct assay:GO:0030121 AP-1 adaptor complex [PMID:10564262]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:17003107]" /note="One of two alternative Mu1-like medium subunits of the clathrin-associated AP-1 complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting" /db_xref="GeneID:855869" /db_xref="SGD:S000006180" ORIGIN 1 masavyfcdh ngkpllsrry rddiplsaid kfpillsdle eqsnlippcl nhngleylfi 61 qhndlyvvai vtslsanaaa iftflhklve vlsdylktve eesirdnfvi iyelldevmd 121 ygipqitetk mlkqyitqks fklvksakkk rnatrppval tnsvswrpeg ithkkneafl 181 divesinmlm tqkgqvlrse iigdvkvnsk lsgmpdlklg indkgifsky ldddtnipsa 241 sattsdnnte tdkkpsitss satnkkkvni eledlkfhqc vrlskfenek iitfippdgk 301 fdlmnyrlst tikpliwcdv nvqvhsnsri eihckakaqi krkstatnve ilipvpddad 361 tptfkyshgs lkyvpeksai lwkirsfpgg keysmsaelg lpsisnnedg nrtmpksnae 421 ilkgpvqikf qipyfttsgi qvrylkinep klqyksypwv ryitqsgddy tirlt // LOCUS NP_015065 551 aa linear PLN 30-JUN-2025 DEFINITION bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015065 VERSION NP_015065.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184072.1 REFERENCE 1 (residues 1 to 551) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 551) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 551) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 551) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 551) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11177. Method: conceptual translation. FEATURES Location/Qualifiers source 1..551 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..551 /product="bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase" /EC_number="2.7.1.49" /EC_number="2.7.4.7" /calculated_mol_wt="61203" Site order(25,32,34..35,37,41,44..45,48,51..56,58,61..65,70..71, 73,75..76,79,82,86..87) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238574" Site order(31,43,64,100,243) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238574" Region 33..292 /region_name="Phos_pyr_kin" /note="Phosphomethylpyrimidine kinase; pfam08543" /db_xref="CDD:430062" Site order(126,163,199,240,242) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238574" Region 343..550 /region_name="HemeO-like" /note="heme oxygenase; cl15243" /db_xref="CDD:449518" CDS 1..551 /gene="THI21" /locus_tag="YPL258C" /coded_by="NM_001184072.1:1..1656" /experiment="EXISTENCE:direct assay:GO:0008902 hydroxymethylpyrimidine kinase activity [PMID:15614489]" /experiment="EXISTENCE:direct assay:GO:0008972 phosphomethylpyrimidine kinase activity [PMID:15614489]" /experiment="EXISTENCE:genetic interaction:GO:0008902 hydroxymethylpyrimidine kinase activity [PMID:15614489]" /experiment="EXISTENCE:genetic interaction:GO:0008972 phosphomethylpyrimidine kinase activity [PMID:15614489|PMID:10383756]" /experiment="EXISTENCE:genetic interaction:GO:0009228 thiamine biosynthetic process [PMID:10383756]" /note="Hydroxymethylpyrimidine (HMP) and HMP-phosphate kinase; involved in thiamine biosynthesis; member of a gene family with THI20 and THI22; functionally redundant with Thi20p" /db_xref="GeneID:855870" /db_xref="SGD:S000006179" ORIGIN 1 mtystvnint pppylalasn eklptvlsia gtdpsggagv eadvktitah rcyamtcita 61 lnaqtpvkvy sinntpkevv sqildanlqd mkcdviktgm lttaaievlh ekllqlgenr 121 pklvvdpvlv atsgsslagk diasliteki apfadiltpn ipecfkllge dreisklrdi 181 fevakdlaki tkcsnilvkg ghipwndeeg kyitdvlylg aeqrfitfkg nfvntththg 241 tgctlasaia snlargyslp qsvyggieyv qnavaigcdv tketvkdngp inhvyaieip 301 lekmlsdecf tasdavhkkp vksslnkipg gsfykylinh pkvkphwdsy vnhdfvrkva 361 dgslepkkfq ffieqdylyl vnyariscia gskspcledl ekelvivecv rnglcqherr 421 lreefgikdp dylqkiqrgp alraycryfn dvsrrgnwqe lvialnpclm gyvhaltkik 481 devtaaegsv yrewcetyss swcheamleg ekllnhilet yppekldtlv tiyaevcele 541 anfwtaaley e // LOCUS NP_058190 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058190 VERSION NP_058190.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184391.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11179. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..440 /product="gag protein" /calculated_mol_wt="48822" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YPL257W-A" /coded_by="NM_001184391.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:855816" /db_xref="SGD:S000007357" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_058189 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058189 VERSION NP_058189.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184392.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11178. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198446" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YPL257W-B" /coded_by="join(NM_001184392.2:1..1305, NM_001184392.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:855817" /db_xref="SGD:S000007358" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp nsapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd eyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydsgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 lyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlsyli qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_015066 193 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL257W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015066 VERSION NP_015066.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184071.1 REFERENCE 1 (residues 1 to 193) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 193) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 193) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 193) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 193) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11180. Method: conceptual translation. FEATURES Location/Qualifiers source 1..193 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..193 /product="uncharacterized protein" /calculated_mol_wt="22066" Region 27..181 /region_name="DUF4668" /note="Domain of unknown function (DUF4668); pfam15701" /db_xref="CDD:406192" CDS 1..193 /locus_tag="YPL257W" /coded_by="NM_001184071.1:1..582" /note="hypothetical protein; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene" /db_xref="GeneID:855818" /db_xref="SGD:S000006178" ORIGIN 1 mtahaneris dvspsargss seskydklcr vlffiaitks sftpehilyk hsiftdkpil 61 adivtfmyaa fvsigwfliw gerayrtqem gqppmysnin yhllsfkkrh pkkftcalwl 121 vfflaytvlt vliwlvqlif rkgnvfqmll qliildiaia lvnvaiaftf eiylsqkaai 181 eirdeglnnl dta // LOCUS NP_015067 545 aa linear PLN 30-JUN-2025 DEFINITION cyclin CLN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015067 VERSION NP_015067.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184070.1 REFERENCE 1 (residues 1 to 545) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 545) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 545) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 545) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 545) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11181. Method: conceptual translation. FEATURES Location/Qualifiers source 1..545 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..545 /product="cyclin CLN2" /calculated_mol_wt="61566" Region 33..524 /region_name="COG5024" /note="Cyclin [Cell division and chromosome partitioning]" /db_xref="CDD:227357" Site order(93,129,160..162,180,183..184) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410262" CDS 1..545 /gene="CLN2" /locus_tag="YPL256C" /coded_by="NM_001184070.1:1..1638" /experiment="EXISTENCE:direct assay:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:2142620]" /experiment="EXISTENCE:direct assay:GO:0001932 regulation of protein phosphorylation [PMID:8387915|PMID:7862657|PMID:10409718]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11792824|PMID:11080155|PMID:10611233]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10611233|PMID:11509671|PMID:11792824|PMID:11080155]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:8387915|PMID:10409718|PMID:7862657]" /experiment="EXISTENCE:genetic interaction:GO:0000321 re-entry into mitotic cell cycle after pheromone arrest [PMID:9927449]" /experiment="EXISTENCE:genetic interaction:GO:0007089 traversing start control point of mitotic cell cycle [PMID:2574633|PMID:2147225]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:11509671]" /experiment="EXISTENCE:mutant phenotype:GO:0007089 traversing start control point of mitotic cell cycle [PMID:2569741]" /note="G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN2 has a paralog, CLN1, that arose from the whole genome duplication; cell cycle arrest phenotype of the cln1 cln2 cln3 triple null mutant is complemented by any of human cyclins CCNA2, CCNB1, CCNC, CCND1, or CCNE1" /db_xref="GeneID:855819" /db_xref="SGD:S000006177" ORIGIN 1 masaeprprm glvinakpdy ypielsnael lshfemlqey hqeistnvia qsckfkpnpk 61 lidqqpemnp vetrsniitf lfelsvvtrv tngiffhsvr lydrycskri vlrdqaklvv 121 atclwlaakt wggcnhiinn vviptggrfy gpnpraripr lselvhycgd gqvfdesmfl 181 qmerhildtl nwniyepmin dyvlnvdenc lmqyelyenq vtydkqcsek rqsqlsqdsd 241 atvderpyqn eeeeeedlkl kiklinlkkf lidvsawqyd llryelfevs hgifsiinqf 301 tnqdhgpflm tpmtseskng eilstlmngi vsipnslmev yktvngvlpf inqvkeyhld 361 lqrklqiasn lnisrkltis tpscsfensn stsipspass sqshtpmrnm sslsdnsvfs 421 rnmeqsspit psmyqfgqqq snsicgstvs vnslvntnnk qriyeqitgp nsnnatndyi 481 dllnlnesnk enqnpatahy lnggppktsf inhgmfpspt gtinsgksss asslisfgmg 541 ntqvi // LOCUS NP_015068 385 aa linear PLN 30-JUN-2025 DEFINITION Bbp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015068 VERSION NP_015068.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184069.1 REFERENCE 1 (residues 1 to 385) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 385) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 385) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 385) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 385) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11182. Method: conceptual translation. FEATURES Location/Qualifiers source 1..385 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..385 /product="Bbp1p" /calculated_mol_wt="45253" Region 10..170 /region_name="BBP1_N" /note="Spindle pole body component BBP1, Mps2-binding protein; pfam15271" /db_xref="CDD:373701" Region 218..383 /region_name="BBP1_C" /note="Spindle pole body component BBP1, C-terminal; pfam15272" /db_xref="CDD:405864" CDS 1..385 /gene="BBP1" /locus_tag="YPL255W" /coded_by="NM_001184069.1:1..1158" /experiment="EXISTENCE:direct assay:GO:0005198 structural molecule activity [PMID:20139001]" /experiment="EXISTENCE:direct assay:GO:0005823 central plaque of spindle pole body [PMID:10654940]" /experiment="EXISTENCE:genetic interaction:GO:0030474 spindle pole body duplication [PMID:10654940]" /experiment="EXISTENCE:mutant phenotype:GO:0030474 spindle pole body duplication [PMID:10654940]" /experiment="EXISTENCE:mutant phenotype:GO:0071988 protein localization to spindle pole body [PMID:14767068|PMID:11952896]" /note="Protein required for the spindle pole body (SPB) duplication; localizes at the cytoplasmic side of the central plaque periphery of the SPB; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p" /db_xref="GeneID:855820" /db_xref="SGD:S000006176" ORIGIN 1 mnqedntggg gifglfkwtk dalfgtdisp smkykdqeer rdrsryaqdd tnfsmkfgnd 61 snrrstnlsr snswsgldst lhrkyellpe ynengfnsiv ngdhhskeri rslrspapiv 121 preplrnept dtfghrlhtk rrtinelsns qipfippqed dpllsklfnk dgvnevrrsp 181 yklsvkdipg kfpspltkrd eidnyyvrde dachknreyk kayfdlfaqm dlnsrdledl 241 cedvreqreq fhrneqtykq ayeemraelv nelkksktlf enyyslgqky kslkkvldqt 301 isheaelats rerlyqeedl knfeiqtlkq rlsdlelkyt nlqiekdmqr dnyeseihdl 361 llqlslrnne rkdtsagsni fstgq // LOCUS NP_015069 488 aa linear PLN 30-JUN-2025 DEFINITION Hfi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015069 VERSION NP_015069.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184068.1 REFERENCE 1 (residues 1 to 488) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 488) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 488) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 488) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 488) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 488) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 488) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11183. Method: conceptual translation. FEATURES Location/Qualifiers source 1..488 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..488 /product="Hfi1p" /calculated_mol_wt="54335" Region 60..316 /region_name="SAGA-Tad1" /note="Transcriptional regulator of RNA polII, SAGA, subunit; pfam12767" /db_xref="CDD:463692" CDS 1..488 /gene="HFI1" /locus_tag="YPL254W" /gene_synonym="ADA1; GAN1; SRM12; SUP110" /coded_by="NM_001184068.1:1..1467" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:9674426]" /experiment="EXISTENCE:direct assay:GO:0046695 SLIK (SAGA-like) complex [PMID:12446794]" /experiment="EXISTENCE:mutant phenotype:GO:0003712 transcription coregulator activity [PMID:9154821]" /experiment="EXISTENCE:mutant phenotype:GO:0003713 transcription coactivator activity [PMID:10048020]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:9154821]" /note="Adaptor protein required for structural integrity of the SAGA complex; a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions" /db_xref="GeneID:855821" /db_xref="SGD:S000006175" ORIGIN 1 msaiqspapk plqptypaas pastnaymkp gligspavsn htepnngnne taepqgpnqr 61 idlgamieel tsllgkeswt kyaqiislfi lgklsrkels nelelvfsps aasleksntn 121 hhhslvrlhn qlllgifans lrenplgrng nesswgfgng snnpnnklkr inkhnsqiev 181 ykkivmslpl ndrnrlkmit keagkrgfif csvfqarlnn ipkipivtnp eslkrvksnn 241 lktplewsqd imngfnvpla seshslpdtd sfylrmvgia rehglvgtvd arcvelisla 301 ldqylkniie ftidtvryrr kkysdyydln esglyksvse maadkrdaki kqldddkned 361 ecadeaksin ngnnsskddi gdismssitk ageavneelh enrtisltne diydslsifp 421 nlvepsgsyy altnlglvnd delvdmksni ddlpdflnek ptftpldern vgtrhelnwl 481 ikgilted // LOCUS NP_015070 647 aa linear PLN 30-JUN-2025 DEFINITION Vik1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015070 VERSION NP_015070.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184067.1 REFERENCE 1 (residues 1 to 647) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 647) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 647) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 647) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11184. Method: conceptual translation. FEATURES Location/Qualifiers source 1..647 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..647 /product="Vik1p" /calculated_mol_wt="75599" Region <80..338 /region_name="SMC_N" /note="RecF/RecN/SMC N terminal domain; cl47134" /db_xref="CDD:481474" Region 354..494 /region_name="Microtub_bd" /note="Microtubule binding; pfam16796" /db_xref="CDD:465274" CDS 1..647 /gene="VIK1" /locus_tag="YPL253C" /coded_by="NM_001184067.1:1..1944" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:10087265|PMID:11729143]" /experiment="EXISTENCE:direct assay:GO:0005871 kinesin complex [PMID:10087265]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:22734002]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0007017 microtubule-based process [PMID:10087265]" /experiment="EXISTENCE:mutant phenotype:GO:0007020 microtubule nucleation [PMID:33752231]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:39841550]" /experiment="EXISTENCE:physical interaction:GO:0007017 microtubule-based process [PMID:10087265]" /note="Subunit of a kinesin-14 heterodimeric motor with Kar3p; localizes Kar3p at mitotic spindle poles; has a structure similar to a kinesin motor domain but lacks an ATP-binding site and is catalytically inactive; binds microtubules; required for sister chromatid cohesion and for ER-associated degradation (ERAD); VIK1 has a paralog, CIK1, that arose from the whole genome duplication" /db_xref="GeneID:855822" /db_xref="SGD:S000006174" ORIGIN 1 masqqnkhaf lsknrifhnp dnvsssksrn lmditnttnt mngsrpssmk sslalppvkd 61 sfpsvsrsas lninmskikd lkdrqdkirf qrhtlrtqli ecereiktik frdlnksrfe 121 lykkkskqak ylkqvrdltq nlnskdgera dlikknksal atlqaeldqn lilkrqesqe 181 lynnklifwe nelqimenve pdheiteeis qlkktlqeln inwanlqkqn lerqvnhesq 241 lrkdfiafke aklksmenlt nkhrelldqi atlqsesekl hkeimdidrq aeyseqnise 301 inenikqlel annplisksl qnsqdlehlq nqmenlkema skqekfyndt yntvekellr 361 srrlensiie qkgtmrcyay vmeqnlpenl lfdyengvit qglsehvykf nrviphlkvs 421 edkfftqeys vyhdmclnqk knfnlislst tphgslresl ikflaekdti yqkqyvitlq 481 fvflsddefs qdmlldyshn dkdsiklkfe khsisldskl viiengledl plnfscdehp 541 nlphsgmgii kvqffprdsk sdgnndpvpv dfyfielnnl ksieqfdksi fkkescetpi 601 alvlkklisd tksffllnln dsknvnkllt iseevqtqlc krkkklt // LOCUS NP_015071 172 aa linear PLN 30-JUN-2025 DEFINITION adrenodoxin [Saccharomyces cerevisiae S288C]. ACCESSION NP_015071 VERSION NP_015071.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184066.1 REFERENCE 1 (residues 1 to 172) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 172) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 172) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 172) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 172) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11185. Method: conceptual translation. FEATURES Location/Qualifiers source 1..172 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..172 /product="adrenodoxin" /calculated_mol_wt="18801" Region 63..165 /region_name="PLN02593" /note="adrenodoxin-like ferredoxin protein" /db_xref="CDD:178203" Site order(94..95,98,101,104..107,143..144) /site_type="active" /note="catalytic loop [active]" /db_xref="CDD:238126" Site order(98,104,107,144) /site_type="other" /note="iron binding site [ion binding]" /db_xref="CDD:238126" CDS 1..172 /gene="YAH1" /locus_tag="YPL252C" /coded_by="NM_001184066.1:1..519" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10375636]" /experiment="EXISTENCE:genetic interaction:GO:0006784 heme A biosynthetic process [PMID:11788607]" /experiment="EXISTENCE:genetic interaction:GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [PMID:11788607]" /experiment="EXISTENCE:mutant phenotype:GO:0006744 ubiquinone biosynthetic process [PMID:20534343|PMID:21944752]" /experiment="EXISTENCE:mutant phenotype:GO:0006784 heme A biosynthetic process [PMID:11788607]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:12970193]" /experiment="EXISTENCE:mutant phenotype:GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [PMID:11788607]" /note="Ferredoxin of the mitochondrial matrix; required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; human homolog FDX1L can complement yeast by allowing growth during down-regulation of yeast YAH1" /db_xref="GeneID:855824" /db_xref="SGD:S000006173" ORIGIN 1 mlkivtragh tarisniaah llrtspsllt rtttttrflp fstssflnhg hlkkpkpgee 61 lkitfilkdg sqktyevceg etildiaqgh nldmegacgg scacstchvi vdpdyydalp 121 epeddendml dlaygltets rlgcqikmsk didgirvalp qmtrnvnnnd fs // LOCUS NP_015073 136 aa linear PLN 30-JUN-2025 DEFINITION Atg41p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015073 VERSION NP_015073.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184064.1 REFERENCE 1 (residues 1 to 136) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 136) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 136) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 136) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 136) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11186. Method: conceptual translation. FEATURES Location/Qualifiers source 1..136 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..136 /product="Atg41p" /calculated_mol_wt="14855" CDS 1..136 /gene="ATG41" /locus_tag="YPL250C" /gene_synonym="ICY2" /coded_by="NM_001184064.1:1..411" /experiment="EXISTENCE:mutant phenotype:GO:0000045 autophagosome assembly [PMID:26565778]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:26565778]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:26565778]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:26565778]" /note="hypothetical protein; required for selective and nonselective autophagy, and mitophagy; regulates the rate of autophagosome formation; interacts with Atg9p, and has a similar peri-mitochondrial localization; elevated Gcn4p-dependent expression under autophagy-inducing conditions; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate; ATG41 has a paralog, ICY1, that arose from the whole genome duplication" /db_xref="GeneID:855825" /db_xref="SGD:S000006171" ORIGIN 1 mssvesspis ryedevfpls fsnvafeppm lshspdrsty addfsqsyqq elltfplsyp 61 ivdesectht kdktdsniit steddcmfdm efngnaasav aaaskesnsa sgfafasnda 121 fanvaqqnyr lwlssv // LOCUS NP_015074 100 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL36 RPL36B [Saccharomyces cerevisiae S288C]. ACCESSION NP_015074 VERSION NP_015074.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184312.1 REFERENCE 1 (residues 1 to 100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 100) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11187. Method: conceptual translation. FEATURES Location/Qualifiers source 1..100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..100 /product="60S ribosomal protein eL36 RPL36B" /calculated_mol_wt="11004" Region 4..99 /region_name="Ribosomal_L36e" /note="Ribosomal protein L36e; pfam01158" /db_xref="CDD:460088" CDS 1..100 /gene="RPL36B" /locus_tag="YPL249C-A" /coded_by="NM_001184312.1:1..303" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:6337137]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /note="Ribosomal 60S subunit protein L36B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L36, no bacterial homolog; RPL36B has a paralog, RPL36A, that arose from the whole genome duplication" /db_xref="GeneID:855826" /db_xref="SGD:S000006438" ORIGIN 1 mavktgiaig lnkgkkvtqm tpapkisykk gaasnrtkfv rslvreiagl spyerrlidl 61 irnsgekrar kvakkrlgsf trakakveem nniiaasrrh // LOCUS NP_015075 894 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein GYP5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015075 VERSION NP_015075.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184063.1 REFERENCE 1 (residues 1 to 894) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 894) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 894) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 894) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 894) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11188. Method: conceptual translation. FEATURES Location/Qualifiers source 1..894 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..894 /product="GTPase-activating protein GYP5" /calculated_mol_wt="101669" Region 154..737 /region_name="COG5210" /note="GTPase-activating protein [General function prediction only]" /db_xref="CDD:227535" Region 720..>860 /region_name="YhaN" /note="Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; COG4717" /db_xref="CDD:443752" CDS 1..894 /gene="GYP5" /locus_tag="YPL249C" /coded_by="NM_001184063.1:1..2685" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005798 Golgi-associated vesicle [PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:12189143|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:15331637|PMID:22842922|PMID:32015451]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:22842922|PMID:15331637]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:35134079]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:15802519|PMID:12189143]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:15802519]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:12189143]" /note="GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication" /db_xref="GeneID:855827" /db_xref="SGD:S000006170" ORIGIN 1 mssdksiekn tdtiasevhe gdnhsnnlgs meeeikstps dqyeeiaiip teplhsdkel 61 ndkqqslghe aptnvsreep igisgdedtq iteqnvneqr qetrepssei dlnepldvek 121 dvttdvqapn glniekeyda vkenekvyad tkevvsspen revtgknsgg eksssskfld 181 desgtttaan andisissev tperssendn nqihitneva aginlnenke qkaaiedgpv 241 taenlsseta rkvppiptqi inekgdnsse nevsaiptts spplpprqnv atstspklpp 301 rgkqreqppk tknavppple eemksekfrk nfeetkrnsy hhvpltgskt aqlestaein 361 liasryrkts hhlnkegeet reslqegqsf lkstftsfle nlseyneven vneedremfk 421 idwsfwtqvv ndyatvasne penleahvtn gippqirgii wqlmansksr emediyetll 481 dteclheati rrdlrrtkfv aedkmeslyk vikvysvydp dvgytqgmgf iaapllince 541 neaesfgllv glmknyglre lflpgmpglm lmlyqfdrll eehspslynr liregisstm 601 yatqwfltff aykfplefvl rifdivfveg ievllkfavn lmlkneetlv klrfdelldf 661 lkdelfnyyl mgnqddasvv qmglsngnsf kgnddgtfsy nvdlfvhdam tgvyitpltl 721 rryrgeyvei hekeqkkedh yeslriqnhq lqreaqkleh dysilnkeni saaneliqnr 781 lnmemlldek ndlintitdi ksqieeeirk qnlpnpdasl pkadlredle rtisrnnevm 841 rengqleeri telqaeidel ininkeqvst asllerdska kgrkgwtgfk kvfk // LOCUS NP_015076 881 aa linear PLN 30-JUN-2025 DEFINITION galactose-responsive transcription factor GAL4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015076 VERSION NP_015076.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184062.1 REFERENCE 1 (residues 1 to 881) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 881) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 881) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 881) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 881) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11189. Method: conceptual translation. FEATURES Location/Qualifiers source 1..881 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..881 /product="galactose-responsive transcription factor GAL4" /calculated_mol_wt="99272" Region 9..47 /region_name="Zn_clus" /note="Fungal Zn(2)-Cys(6) binuclear cluster domain; pfam00172" /db_xref="CDD:395120" Site order(10,15..18,20,23,33) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(11,14,21,28,31,38) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 50..95 /region_name="ZIP_Gal4" /note="Leucine zipper Dimerization domain of transcription factor Gal4 and similar fungal proteins; cd14654" /db_xref="CDD:271238" Site order(50..51,53..54,57..58,60..61,64..66,68,70..72,78,81, 89..90,93) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:271238" Site 50..51 /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:271238" Region 52..72 /region_name="coiled coil" /note="coiled coil [structural motif]" /db_xref="CDD:271238" Region 236..643 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..881 /gene="GAL4" /locus_tag="YPL248C" /gene_synonym="GAL81" /coded_by="NM_001184062.1:1..2646" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:3886158]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:3080805]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:6091123]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:3886158]" /experiment="EXISTENCE:direct assay:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14871930]" /experiment="EXISTENCE:genetic interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:14871930]" /experiment="EXISTENCE:mutant phenotype:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:14871930]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:3080805]" /experiment="EXISTENCE:mutant phenotype:GO:0006012 galactose metabolic process [PMID:6350827]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:6350827]" /experiment="EXISTENCE:physical interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:14871930]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14871930]" /note="DNA-binding transcription factor required for activating GAL genes; responds to galactose; repressed by Gal80p and activated by Gal3p" /db_xref="GeneID:855828" /db_xref="SGD:S000006169" ORIGIN 1 mkllssieqa cdicrlkklk cskekpkcak clknnwecry spktkrsplt rahltevesr 61 lerleqlfll ifpredldmi lkmdslqdik alltglfvqd nvnkdavtdr lasvetdmpl 121 tlrqhrisat ssseessnkg qrqltvsids aahhdnstip ldfmprdalh gfdwseeddm 181 sdglpflktd pnnngffgdg sllcilrsig fkpenytnsn vnrlptmitd rytlasrstt 241 srllqsylnn fhpycpivhs ptlmmlynnq ieiaskdqwq ilfncilaig awciegestd 301 idvfyyqnak shltskvfes gsiilvtalh llsrytqwrq ktntsynfhs fsirmaislg 361 lnrdlpssfs dssileqrrr iwwsvyswei qlsllygrsi qlsqntisfp ssvddvqrtt 421 tgptiyhgii etarllqvft kiyeldktvt aekspicakk clmicneiee vsrqapkflq 481 mdisttaltn llkehpwlsf trfelkwkql sliiyvlrdf ftnftqkksq leqdqndhqs 541 yevkrcsiml sdaaqrtvms vssymdnhnv tpyfawncsy ylfnavlvpi ktllsnsksn 601 aennetaqll qqintvlmll kklatfkiqt cekyiqvlee vcapfllsqc aiplphisyn 661 nsngsaikni vgsatiaqyp tlpeenvnni svkyvspgsv gpspvplksg asfsdlvkll 721 snrppsrnsp vtiprstpsh rsvtpflgqq qqlqslvplt psalfgganf nqsgniadss 781 lsftftnssn gpnlittqtn sqalsqpias snvhdnfmnn eitaskiddg nnskplspgw 841 tdqtaynafg ittgmfnttt mddvynylfd dedtppnpkk e // LOCUS NP_015077 523 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL247C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015077 VERSION NP_015077.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184061.1 REFERENCE 1 (residues 1 to 523) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 523) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 523) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 523) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 523) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11190. Method: conceptual translation. FEATURES Location/Qualifiers source 1..523 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..523 /product="uncharacterized protein" /calculated_mol_wt="57193" Region 177..>426 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 179..217 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 252..284 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 290..343 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 352..391 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 397..422 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 443..489 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..523 /locus_tag="YPL247C" /coded_by="NM_001184061.1:1..1572" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest" /db_xref="GeneID:855829" /db_xref="SGD:S000006168" ORIGIN 1 mdpfhngnkr ssisfgssqr qpynknnyls gtngpssaaq dqgrgpspfg msgnttnggn 61 skrnsgcdls atyyasrspm yspldfsppv fspnhsqlqq argyaanipv vsnlmnpsma 121 svceyqshyp lfgldwsadd yvclgsyked srnklqvlhs ndllswesvv dadvvypvsk 181 iqwvpsqlyp rklatcsdsl riwsvspeer qfqeqinlsl ckynrqhpan paaaddmkvi 241 gtfppitsfd wntvdtnlii sssidttciv wdlqsshyvk tqliahdsev fdvrfltkst 301 qlfascggdg svrvfdlrsl ahstiiyepp sssvsgatag titpsskgsd allrlepspy 361 dpnvlatfaa dsnkiiildm rnpespilnl qghgssvngi kwhptkrnvl lscgddcqvl 421 ywdlnssfme inaagsksps ihgtsledpd gdtemtdgga gsglnedpls lnnnskqvck 481 tletpnmmya nktqeinnia wrpqrgdwfg cvsgkkfqnv rvl // LOCUS NP_015078 262 aa linear PLN 30-JUN-2025 DEFINITION putative rhomboid protease RBD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015078 VERSION NP_015078.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184060.1 REFERENCE 1 (residues 1 to 262) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 262) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 262) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 262) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 262) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 262) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 262) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11191. Method: conceptual translation. FEATURES Location/Qualifiers source 1..262 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..262 /product="putative rhomboid protease RBD2" /EC_number="3.4.21.105" /calculated_mol_wt="29369" Region 47..196 /region_name="Rhomboid" /note="Rhomboid family; pfam01694" /db_xref="CDD:426384" CDS 1..262 /gene="RBD2" /locus_tag="YPL246C" /coded_by="NM_001184060.1:1..789" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /note="Possible rhomboid protease; has similarity to eukaryotic rhomboid proteases including Pcp1p" /db_xref="GeneID:855830" /db_xref="SGD:S000006167" ORIGIN 1 mnwksyvfpg ghppaalttg lvvfltaiyl lsfifalred lslapeslfk lqmsrlslyp 61 lihlslphll fnvlaiwapl nlfeethgtv ytgvflnlsa lfagilycll gkllypealv 121 agasgwcftl fayysfkesq irprtrifrt dysiptlytp lvllvaiavv ipgssfwghf 181 fglcvgyaig ykeswfnkit ppgwiitkie ksldglirli pwgikyyrde didrtkdyep 241 lmstetplpl hndnsgtvlg ta // LOCUS NP_015079 454 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL245W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015079 VERSION NP_015079.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184059.1 REFERENCE 1 (residues 1 to 454) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 454) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 454) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 454) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11192. Method: conceptual translation. FEATURES Location/Qualifiers source 1..454 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..454 /product="uncharacterized protein" /calculated_mol_wt="52126" Region 69..441 /region_name="DUF2075" /note="Schlafen group 3, DNA/RNA helicase domain; pfam09848" /db_xref="CDD:430875" CDS 1..454 /locus_tag="YPL245W" /coded_by="NM_001184059.1:1..1365" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm" /db_xref="GeneID:855831" /db_xref="SGD:S000006166" ORIGIN 1 mhgptskais rnvrsvkrpr raprpvvstq amnklsnvtl saeqeklrer vlsfmrsnls 61 qyksdwkhpa mfviqgdagt gksvilnslf neiqklsqfs pssedilhgt hnylvvnhpe 121 mlklyirisd sfkyiskssl erptslinnl qkrkvmadvv ivdeahllat skdafkrfyg 181 enhlkdlmsl ckvlvlvydd kqalrmgsyw degsnngatl kdfyneippk srdwytlkqq 241 frvaapqnvl nwidqisvag kippiesvls kgnadcaddk iknfdfkiwd dcgamyeaik 301 ekdrqygqcr mlstydfpyr ldgkdyyvec gdnfkvrwdr ytprevtpws ercdtidevg 361 svytiqgfdl nyagvilgrs igydaandci klrpelyddr agftkkknih naedvkqkii 421 mnsinvlltr gvrglyvyay dpelrerllr pskk // LOCUS NP_015080 339 aa linear PLN 30-JUN-2025 DEFINITION UDP-galactose transporter HUT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015080 VERSION NP_015080.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184058.1 REFERENCE 1 (residues 1 to 339) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 339) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 339) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 339) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 339) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11193. Method: conceptual translation. FEATURES Location/Qualifiers source 1..339 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..339 /product="UDP-galactose transporter HUT1" /calculated_mol_wt="37945" Region 7..321 /region_name="UAA" /note="UAA transporter family; pfam08449" /db_xref="CDD:462479" CDS 1..339 /gene="HUT1" /locus_tag="YPL244C" /coded_by="NM_001184058.1:1..1020" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015786 UDP-glucose transmembrane transport [PMID:18693752]" /experiment="EXISTENCE:mutant phenotype:GO:0015786 UDP-glucose transmembrane transport [PMID:18693752]" /experiment="EXISTENCE:mutant phenotype:GO:0072334 UDP-galactose transmembrane transport [PMID:11284009]" /note="Protein with a role in UDP-galactose transport to the Golgi lumen; has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1" /db_xref="GeneID:855832" /db_xref="SGD:S000006165" ORIGIN 1 magstsslvi caigiyatfl twalvqepla trtwpnsmgk fqfpnvisli qasvammmgy 61 lylnwkkvey pprkmikdhw kqlmlisftq sssgplatts lkhvdyltym laksckmipv 121 llvhlllyrt piasqkkvva llvslgvtif tiggndgkkl krsfnesgnd nklqgfgllf 181 sslfldgltn atqdkllkan kakekgkqtl itgahlmftl nlfvilwnil yfividckqw 241 dnavsvltmd pqvwgylmly sfcgamgqcf ifytleqfgs lvlimitvtr kmvsmilsii 301 vfgksvrfqq wvgmfivfgg itwealnkkk anipkaksa // LOCUS NP_015081 599 aa linear PLN 30-JUN-2025 DEFINITION signal recognition particle subunit SRP68 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015081 VERSION NP_015081.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184057.1 REFERENCE 1 (residues 1 to 599) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 599) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 599) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 599) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11194. Method: conceptual translation. FEATURES Location/Qualifiers source 1..599 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..599 /product="signal recognition particle subunit SRP68" /calculated_mol_wt="68875" Site order(16,26..27,29,31,33..38,40..42,73,84,88,105..106, 108..109,112..113,116,119) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:271252" Region 24..551 /region_name="SRP68-RBD" /note="RNA-binding domain of signal recognition particle subunit 68; cl22422" /db_xref="CDD:473954" CDS 1..599 /gene="SRP68" /locus_tag="YPL243W" /coded_by="NM_001184057.1:1..1800" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]" /experiment="EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /note="Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress" /db_xref="GeneID:855833" /db_xref="SGD:S000006164" ORIGIN 1 mvayspiiat ygnraeqfle tdsdfakyha klnkklqhlr srchlvtkdt kkyssknkyg 61 einsedydnk tkligvlill haerdlalae tlklrarqrg klkkseekvl strlkkackt 121 adklvnvtqn eqqwitraqy lafaklvhse ylingkrfkr kdnakisnnl alvfaalehl 181 knlsllaeev vdnivnkyqy slkqyagnli ttpeinnfiv ervqsdenkd delvkllldn 241 gfnmkkitts tedqkvttni nwrsfnakii daevaqfleq glsihptqit qytqrlskle 301 kaldrheffi anhddqddid emvenssenn qiilayikyn illtsisrer dlfthlwnqw 361 lklntslpsk ltkykemeri vknltkylsd imelpgvysd dellsqldlc klyfqlflnt 421 gclsvlyqsk grymealaly vdayrrlenk lseiesldei llpanllsln svrslqkrie 481 nggnsvitla eyekrnhggs lgkydltvie kldskkilpt diqlknlfpl kpkmlpipsk 541 ptlfdlafny itydkqepsa sqvkdsvtet esisqtpisn eqtegepkkk rgflglfgr // LOCUS NP_015082 1495 aa linear PLN 30-JUN-2025 DEFINITION Iqg1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015082 VERSION NP_015082.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184056.1 REFERENCE 1 (residues 1 to 1495) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1495) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1495) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1495) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1495) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11195. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1495 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1495 /product="Iqg1p" /calculated_mol_wt="172700" Region 1..1494 /region_name="IQG1" /note="Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]; COG5261" /db_xref="CDD:227586" CDS 1..1495 /gene="IQG1" /locus_tag="YPL242C" /gene_synonym="CYK1" /coded_by="NM_001184056.1:1..4488" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:10873803|PMID:9950677|PMID:9442111|PMID:9382845]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:11082046|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:9950677|PMID:9382845]" /experiment="EXISTENCE:direct assay:GO:0120155 MIH complex [PMID:24895401]" /experiment="EXISTENCE:mutant phenotype:GO:0000281 mitotic cytokinesis [PMID:21173112]" /experiment="EXISTENCE:mutant phenotype:GO:0051015 actin filament binding [PMID:9382845|PMID:9950677]" /experiment="EXISTENCE:mutant phenotype:GO:0072741 protein localization to cell division site [PMID:21173112]" /experiment="EXISTENCE:mutant phenotype:GO:1903471 regulation of mitotic actomyosin contractile ring contraction [PMID:24895401|PMID:26085509|PMID:9950677|PMID:19109423]" /experiment="EXISTENCE:mutant phenotype:GO:1903475 mitotic actomyosin contractile ring assembly [PMID:21173112|PMID:11082046]" /experiment="EXISTENCE:mutant phenotype:GO:1903479 mitotic actomyosin contractile ring assembly actin filament organization [PMID:9442111|PMID:9950677|PMID:9382845]" /experiment="EXISTENCE:physical interaction:GO:0005516 calmodulin binding [PMID:9950677]" /experiment="EXISTENCE:physical interaction:GO:0032027 myosin light chain binding [PMID:10873803]" /experiment="EXISTENCE:physical interaction:GO:0032033 myosin II light chain binding [PMID:11082046]" /experiment="EXISTENCE:physical interaction:GO:0032038 myosin II heavy chain binding [PMID:11082046]" /experiment="EXISTENCE:physical interaction:GO:0120155 MIH complex [PMID:24895401]" /note="Actin filament binding protein that enhances actin ring formation; IQGAP family member required for assembly and contraction of the AMR, prior to cytokinesis; localizes to the contractile ring during anaphase in an Mlc1p-dependent manner, recruiting Myo1p and Hof1p to the site, and promoting cytokinetic core complex assembly; specifies bud-site selection, localizing axial markers Bud4p and Cdc12p; regulated by Cdc28p; relocalizes from the bud neck to the cytoplasm upon replication stress" /db_xref="GeneID:855834" /db_xref="SGD:S000006163" ORIGIN 1 mtaysgspsk pgnnnsylnr yvenlgtnvt pplrpqsssk insslniasp shlktktsas 61 nssatilskk vessvsklkp slpnklvgky tvdlsnyski elryyeflcr vsevkiwiea 121 vieealpsei elcvgdslrn gvflakltqr inpdlttvif pagdklqfkh tqninaffgl 181 vehvgvpdsf rfelqdlynk knipqvfetl hilisminkk wpgktpaltn vsgqisftke 241 eiaackkawp rirdfkslgt nintapaspe epkekrsgli kdfnkferpn ipveeilitp 301 rknitdancs dfsntpspyn eapkmsnldv vvekrkftpi epsllgptps leyspiknks 361 lsyysptisk yltydtefyt rrsrareedl nyyqtfkysp shyspmrrer mteeqflekv 421 vqlqnicrgv ntrfnlyiqk rllnlfeqdi lrfqaclrgn kfrvlssmyl pirrakidvp 481 hveaiqsrik gsrirykydk lkftlsrfsc tvellqaycr skllkttvnt klndieishy 541 pltklqsymr asyvrkkvms lntklndere simkfsaiir gnvvrcseda ilsavhdvhk 601 enisklqsli rgiftrscla siiyslgken cniiqlsaci rgnavrhkvq slfapennls 661 etvhdlqglv rgilvrytld lvddiveynn lalfqafsrg alvresldqk ssfykrnvrs 721 vimiqswirk slqrsaylel ldcpnpslwa vkkfvhllng tatieevqnq lescqaslds 781 enmkkerllk sirqqlning vldkfgllkd kdhelgisds tipkskyqky eklfymlqvd 841 psywkllylk epefvaknvy mtfgtvnqrm ndrersyftr fvcemlqnai neapsiesfl 901 dnrsqfwqti lqdflrresp effsiivpvl dylsdpvvdf esdpykiyqe ihgfsspqhc 961 spvddastkn kfidnlrclw haiemvaeiy trkvhtipve irylctkifc yaadknieei 1021 dslraissil vnvfvseylv nreyygykds nvqknnqkid ilmkslatvf eiknfdgfld 1081 plnqyaneik phikdvlynv lvdpeyeqeg drliyldmvs pspklellte kvleisgkfe 1141 eylnefpead ilhdileknl dnssfprsgr vtleldasay rflvsddkmr kiydqvkraf 1201 vymmqiedvd tnlydlsist ilpqdepnfa nfleqnpkir ddpmiqklkp lkyftlknvt 1261 lkkihelest gtfcssdnkl qnflndiant iknpnyaidy vtqeiyitke tltkisemnh 1321 sldielsrlk khvdhtikdf qkakdfspvh kskfgnfkna vkkvqgrers elqgmkfkwn 1381 tkqlyergvl ktirgeklae ltvkvfgssg pkfpdiifki stsdgsrfgi qmidkrkgpd 1441 krysddvdsf sfkdliktqv epkietwklf hsnvvvnnsq llhlivsffy krnal // LOCUS NP_015083 268 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein CIN2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015083 VERSION NP_015083.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184055.1 REFERENCE 1 (residues 1 to 268) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 268) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 268) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 268) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11196. Method: conceptual translation. FEATURES Location/Qualifiers source 1..268 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..268 /product="GTPase-activating protein CIN2" /calculated_mol_wt="30578" Region 118..>220 /region_name="TBCC" /note="Tubulin binding cofactor C; cl29757" /db_xref="CDD:475252" CDS 1..268 /gene="CIN2" /locus_tag="YPL241C" /coded_by="NM_001184055.1:1..807" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:18376416]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:2407611]" /experiment="EXISTENCE:genetic interaction:GO:0007021 tubulin complex assembly [PMID:9215891]" /experiment="EXISTENCE:mutant phenotype:GO:0007021 tubulin complex assembly [PMID:9215891]" /note="GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; human homolog RP2 complements yeast null mutant" /db_xref="GeneID:855835" /db_xref="SGD:S000006162" ORIGIN 1 mdftakikel erelsetsdy ktlqkktisl rselntlshs ltsyekehfs ndienvlksi 61 naklseskgk krlfsfkqkn sssavhknve rtelanapay tttlkkhyvl ekgdsafenl 121 efctvtsttd ysgnsalsgs lcfrnitkcv inlqriffqt gsifitdctd siiflrspsd 181 kdfqirlrdl knckiliekl spsidckqvv iienchkcif nastrdhlii qdfsnpfqse 241 etednsafaf edfdicnkdt mqlfrayl // LOCUS NP_015084 709 aa linear PLN 30-JUN-2025 DEFINITION Hsp90 family chaperone HSP82 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015084 VERSION NP_015084.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184054.1 REFERENCE 1 (residues 1 to 709) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 709) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 709) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 709) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 709) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11197. Method: conceptual translation. FEATURES Location/Qualifiers source 1..709 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..709 /product="Hsp90 family chaperone HSP82" /calculated_mol_wt="81276" Region 3..709 /region_name="HSP90" /note="Hsp90 protein; cl46693" /db_xref="CDD:481033" CDS 1..709 /gene="HSP82" /locus_tag="YPL240C" /gene_synonym="HSP90" /coded_by="NM_001184054.1:1..2130" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:32920053]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:27385335|PMID:32920053|PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006458 'de novo' protein folding [PMID:10564510]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:12235160]" /experiment="EXISTENCE:direct assay:GO:0032212 positive regulation of telomere maintenance via telomerase [PMID:17954556]" /experiment="EXISTENCE:direct assay:GO:0043248 proteasome assembly [PMID:12853471]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:10564510]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:18268103]" /experiment="EXISTENCE:mutant phenotype:GO:0006458 'de novo' protein folding [PMID:9371781]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:16487343]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:27068472]" /experiment="EXISTENCE:mutant phenotype:GO:0032212 positive regulation of telomere maintenance via telomerase [PMID:17954556]" /experiment="EXISTENCE:mutant phenotype:GO:0042026 protein refolding [PMID:9371781]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:12853471]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:27068472]" /experiment="EXISTENCE:physical interaction:GO:0006626 protein targeting to mitochondrion [PMID:12526792]" /note="Hsp90 chaperone; functionally redundant with Hsc82p; required for pheromone signaling; negative regulator of the Hsf1p-dependent heat shock response with Cpr7p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; promotes solubility of chaperone-substrate complexes; DNA damage induced nuclear import is Aha1p dependent; protein abundance increases in response to DNA replication stress; human homolog, HSP90AB1, complements null mutant" /db_xref="GeneID:855836" /db_xref="SGD:S000006161" ORIGIN 1 masetfefqa eitqlmslii ntvysnkeif lrelisnasd aldkiryksl sdpkqletep 61 dlfiritpkp eqkvleirds gigmtkaeli nnlgtiaksg tkafmealsa gadvsmigqf 121 gvgfyslflv adrvqvisks nddeqyiwes naggsftvtl devnerigrg tilrlflkdd 181 qleyleekri kevikrhsef vaypiqlvvt kevekevpip eeekkdeekk deekkdeddk 241 kpkleevdee eekkpktkkv keevqeieel nktkplwtrn psditqeeyn afyksisndw 301 edplyvkhfs vegqlefrai lfipkrapfd lfeskkkknn iklyvrrvfi tdeaedlipe 361 wlsfvkgvvd sedlplnlsr emlqqnkimk virknivkkl ieafneiaed seqfekfysa 421 fskniklgvh edtqnraala kllrynstks vdeltsltdy vtrmpehqkn iyyitgeslk 481 avekspflda lkaknfevlf ltdpideyaf tqlkefegkt lvditkdfel eetdeekaer 541 ekeikeyepl tkalkeilgd qvekvvvsyk lldapaairt gqfgwsanme rimkaqalrd 601 ssmssymssk ktfeispksp iikelkkrvd eggaqdktvk dltkllyeta lltsgfslde 661 ptsfasrinr lislglnide deetetapea staapveevp adtemeevd // LOCUS NP_015085 200 aa linear PLN 30-JUN-2025 DEFINITION Yar1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015085 VERSION NP_015085.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184053.1 REFERENCE 1 (residues 1 to 200) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 200) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 200) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 200) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11198. Method: conceptual translation. FEATURES Location/Qualifiers source 1..200 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..200 /product="Yar1p" /calculated_mol_wt="22224" Site order(11,13,17..18,21..23,25..26,30,33,47,49,51,55..56, 59..61,63..64,68,71,90,92,94,98..99,102..104,106..107,111, 115,124) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 11..47 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 20..70 /region_name="Ank_4" /note="Ankyrin repeats (many copies); pfam13637" /db_xref="CDD:372654" Region 49..90 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region <52..149 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 92..124 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" CDS 1..200 /gene="YAR1" /locus_tag="YPL239W" /coded_by="NM_001184053.1:1..603" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22570489]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0051082 unfolded protein binding [PMID:26112308]" /experiment="EXISTENCE:genetic interaction:GO:0000056 ribosomal small subunit export from nucleus [PMID:22570489]" /experiment="EXISTENCE:genetic interaction:GO:0005634 nucleus [PMID:22570489]" /experiment="EXISTENCE:genetic interaction:GO:0042274 ribosomal small subunit biogenesis [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:22570489]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:22570489]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:15611164]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:22570489]" /experiment="EXISTENCE:physical interaction:GO:0032880 regulation of protein localization [PMID:22570489]" /note="Nucleocytoplasmic shuttling assembly chaperone; co-translationally associates with nascent Rps3p in the cytoplasm and delivers it to pre-ribosomal subunits in the nucleus; required for 40S ribosomal subunit nuclear export, biogenesis and adaptation to osmotic and oxidative stress; contains ankyrin-repeats; expression repressed by heat shock" /db_xref="GeneID:855837" /db_xref="SGD:S000006160" ORIGIN 1 mglhsepldq edqdtiilda ragdldslkd ifttlvspel lstckesesd stalhmaaan 61 ghietvryil etvsransae dlkafvnevn ktgntalhwa slngkldvvk llcdeyeadp 121 firnkfghda ifeaensgke evetyflkky dvepeddeed tqtegknsvq itkgteieqv 181 tkeatealre eteklninkd // LOCUS NP_015087 285 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF2 subunit beta [Saccharomyces cerevisiae S288C]. ACCESSION NP_015087 VERSION NP_015087.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184051.1 REFERENCE 1 (residues 1 to 285) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 285) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 285) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 285) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 285) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11199. Method: conceptual translation. FEATURES Location/Qualifiers source 1..285 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..285 /product="translation initiation factor eIF2 subunit beta" /calculated_mol_wt="31443" Region 156..264 /region_name="eIF2B_5" /note="domain present in translation initiation factor eIF2B and eIF5; smart00653" /db_xref="CDD:214764" CDS 1..285 /gene="SUI3" /locus_tag="YPL237W" /coded_by="NM_001184051.1:1..858" /experiment="EXISTENCE:direct assay:GO:0001731 formation of translation preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:9858542]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:16246727|PMID:14698289]" /experiment="EXISTENCE:direct assay:GO:0005850 eukaryotic translation initiation factor 2 complex [PMID:12137565]" /experiment="EXISTENCE:direct assay:GO:0016282 eukaryotic 43S preinitiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:15145951|PMID:22683627|PMID:9395514]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:11018020|PMID:15838098]" /experiment="EXISTENCE:direct assay:GO:1990856 methionyl-initiator methionine tRNA binding [PMID:16565414]" /experiment="EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:16449648]" /experiment="EXISTENCE:mutant phenotype:GO:0003743 translation initiation factor activity [PMID:12137565]" /experiment="EXISTENCE:mutant phenotype:GO:0005850 eukaryotic translation initiation factor 2 complex [PMID:12137565]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:22683627|PMID:15145951|PMID:9395514]" /note="Beta subunit of the translation initiation factor eIF2; involved in the identification of the start codon; proposed to be involved in mRNA binding" /db_xref="GeneID:855838" /db_xref="SGD:S000006158" ORIGIN 1 mssdlaaelg fdpalkkkkk tkkvipddfd aavngkengs gddlfaglkk kkkksksvsa 61 daeaekeptd diaealgels lkkkkkktkd ssvdafekel akagldnvda eskegtpsan 121 ssiqqevglp ysellsrffn ilrtnnpela gdrsgpkfri pppvclrdgk ktifsniqdi 181 aeklhrspeh liqylfaelg tsgsvdgqkr lvikgkfqsk qmenvlrryi leyvtcktck 241 sintelkreq snrlffmvck scgstrsvss iktgfqatvg krrrm // LOCUS NP_015088 364 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase ENV7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015088 VERSION NP_015088.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184050.1 REFERENCE 1 (residues 1 to 364) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 364) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 364) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 364) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 364) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11200. Method: conceptual translation. FEATURES Location/Qualifiers source 1..364 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..364 /product="putative serine/threonine protein kinase ENV7" /EC_number="2.7.11.1" /calculated_mol_wt="40618" Region 29..353 /region_name="STKc_16" /note="Catalytic domain of Serine/Threonine Kinase 16; cd13986" /db_xref="CDD:270888" Site order(36..40,44,67,69,98,119..122,126,128,215,217,219..220, 222,233,236,261..264) /site_type="active" /db_xref="CDD:270888" Site order(36..40,44,67,69,98,119..122,126,215,217,219..220,222, 233) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270888" Site order(40,126,128,215,217,219,236,261..264) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270888" Site order(232..258,260..264) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270888" CDS 1..364 /gene="ENV7" /locus_tag="YPL236C" /coded_by="NM_001184050.1:1..1095" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006624 vacuolar protein processing [PMID:21912603]" /experiment="EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:24610781]" /note="Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; targeted to vacuole via AP-3 pathway; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)" /db_xref="GeneID:855840" /db_xref="SGD:S000006157" ORIGIN 1 misivlelfq nlcccrgfsd atirvndkry riqrllgegg msfvylvqls knsliidngi 61 atpelyalkk iicpsvesis ngmreienyk rfqspyviks idsqvmqekd gsktiyivlp 121 yyslgslqds inrrllegtf vseaecvrim lgvtrgllcl hdpasrqdna tsrvnvdavs 181 mtysdetaml ledtplemdm lssnsagsia yahrditpsn ilfssdglpv igdlgscsqa 241 ditienrhql selqewvndn ctlpytppel lnlklnqvls skvdiwslgc tfytlmfgis 301 pfereeqihg asltyaintg kysfprnsrf segllsvikk ciqvdpiqrp ttsqllnllq 361 dldt // LOCUS NP_015089 471 aa linear PLN 30-JUN-2025 DEFINITION RuvB family ATP-dependent DNA helicase reptin [Saccharomyces cerevisiae S288C]. ACCESSION NP_015089 VERSION NP_015089.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184049.1 REFERENCE 1 (residues 1 to 471) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 471) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 471) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 471) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 471) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11201. Method: conceptual translation. FEATURES Location/Qualifiers source 1..471 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..471 /product="RuvB family ATP-dependent DNA helicase reptin" /EC_number="3.6.4.12" /calculated_mol_wt="51481" Region 20..362 /region_name="TIP49" /note="TIP49 P-loop domain; pfam06068" /db_xref="CDD:399217" Region 367..432 /region_name="TIP49_C" /note="TIP49 AAA-lid domain; pfam17856" /db_xref="CDD:436097" CDS 1..471 /gene="RVB2" /locus_tag="YPL235W" /gene_synonym="TIH2; TIP48; TIP49B" /coded_by="NM_001184049.1:1..1416" /experiment="EXISTENCE:direct assay:GO:0000812 Swr1 complex [PMID:16299513]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11604509]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:10952318|PMID:20553504]" /experiment="EXISTENCE:direct assay:GO:0043139 5'-3' DNA helicase activity [PMID:18234224]" /experiment="EXISTENCE:direct assay:GO:0097255 R2TP complex [PMID:15766533]" /experiment="EXISTENCE:direct assay:GO:0110078 TTT Hsp90 cochaperone complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:18268103|PMID:11604509]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11278922]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:11604509]" /experiment="EXISTENCE:physical interaction:GO:0000812 Swr1 complex [PMID:14690608|PMID:14645854]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:14690608]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245|PMID:10952318]" /experiment="EXISTENCE:physical interaction:GO:0097255 R2TP complex [PMID:18268103]" /note="ATP-dependent DNA helicase, also known as reptin; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, the R2TP complex (Rvb1-Rvb2-Tah1-Pih1) and the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly; member of the AAA+ and RuvB protein families, similar to Rvb1p" /db_xref="GeneID:855841" /db_xref="SGD:S000006156" ORIGIN 1 msiqtsdpne tsdlkslsli aahshitglg ldenlqprpt segmvgqlqa rraagvilkm 61 vqngtiagra vlvagppstg ktalamgvsq slgkdvpfta iagseifsle lsktealtqa 121 frksigikik eeteliegev veiqidrsit gghkqgklti kttdmetiye lgnkmidglt 181 kekvlagdvi sidkasgkit klgrsfarsr dydamgadtr fvqcpegelq krktvvhtvs 241 lheidvinsr tqgflalftg dtgeirsevr dqintkvaew keegkaeivp gvlfidevhm 301 ldiecfsfin raledefapi vmmatnrgvs ktrgtnyksp hglpldlldr siiittksyn 361 eqeiktilsi raqeeevels sdaldlltkt gvetslryss nlisvaqqia mkrknntvev 421 edvkrayllf ldsarsvkyv qenesqyidd qgnvqisiak sadpdamdtt e // LOCUS NP_015090 164 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V0 sector ATPase subunit c' [Saccharomyces cerevisiae S288C]. ACCESSION NP_015090 VERSION NP_015090.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184048.1 REFERENCE 1 (residues 1 to 164) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 164) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 164) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 164) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 164) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11202. Method: conceptual translation. FEATURES Location/Qualifiers source 1..164 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..164 /product="H(+)-transporting V0 sector ATPase subunit c'" /calculated_mol_wt="16906" Region 17..124 /region_name="PRK13469" /note="F0F1 ATP synthase subunit C; Provisional; cl00466" /db_xref="CDD:469780" Region 92..159 /region_name="ATP-synt_Vo_c_ATP6C_rpt2" /note="V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins; cd18176" /db_xref="CDD:349416" CDS 1..164 /gene="VMA11" /locus_tag="YPL234C" /gene_synonym="CLS9; TFP3" /coded_by="NM_001184048.1:1..495" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:11853670]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:15252052]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Vacuolar ATPase V0 domain subunit c'; involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen" /db_xref="GeneID:855842" /db_xref="SGD:S000006155" ORIGIN 1 mstqlasniy aplyapffgf agcaaamvls clgaaigtak sgigiagigt fkpelimksl 61 ipvvmsgila iyglvvavli agnlsptedy tlfngfmhls cglcvgfacl ssgyaigmvg 121 dvgvrkymhq prlfvgivli lifsevlgly gmivalilnt rgse // LOCUS NP_015091 216 aa linear PLN 30-JUN-2025 DEFINITION MIND complex subunit NSL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015091 VERSION NP_015091.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184047.1 REFERENCE 1 (residues 1 to 216) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 216) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 216) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 216) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 216) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11203. Method: conceptual translation. FEATURES Location/Qualifiers source 1..216 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..216 /product="MIND complex subunit NSL1" /calculated_mol_wt="25285" Region 62..195 /region_name="Mis14" /note="Kinetochore protein Mis14 like; pfam08641" /db_xref="CDD:430124" CDS 1..216 /gene="NSL1" /locus_tag="YPL233W" /coded_by="NM_001184047.1:1..651" /experiment="EXISTENCE:direct assay:GO:0000444 MIS12/MIND type complex [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:14657030]" /experiment="EXISTENCE:direct assay:GO:0000922 spindle pole [PMID:12455957]" /experiment="EXISTENCE:direct assay:GO:0007059 chromosome segregation [PMID:12455957]" /note="Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND)" /db_xref="GeneID:855843" /db_xref="SGD:S000006154" ORIGIN 1 msqgqskkld vtveqlrsiy hqfhdileek tdlhlpkkey dddavrrevq iqlqefllsa 61 mtmaskslev vnadtvgktv kqlimesqek ymepfdldln eqvrkmyqew edetvkvaql 121 rqtgpakine vynnskdeyl aqldgrigvl qarmmqqqsa dhddstddad dhinwehikq 181 dyvaslnely qtqqdlpkvr ynvekvkrlm dfleed // LOCUS NP_015092 290 aa linear PLN 30-JUN-2025 DEFINITION syntaxin [Saccharomyces cerevisiae S288C]. ACCESSION NP_015092 VERSION NP_015092.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184046.1 REFERENCE 1 (residues 1 to 290) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 290) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 290) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 290) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 290) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11204. Method: conceptual translation. FEATURES Location/Qualifiers source 1..290 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..290 /product="syntaxin" /calculated_mol_wt="32975" Region 1..268 /region_name="COG5074" /note="t-SNARE complex subunit, syntaxin [Intracellular trafficking, secretion, and vesicular transport]" /db_xref="CDD:227406" CDS 1..290 /gene="SSO1" /locus_tag="YPL232W" /coded_by="NM_001184046.1:1..873" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19502581]" /experiment="EXISTENCE:direct assay:GO:0005484 SNAP receptor activity [PMID:16339720]" /experiment="EXISTENCE:direct assay:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:19502581]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:19502581|PMID:17298976]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:19502581|PMID:17298976|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0006906 vesicle fusion [PMID:11001046]" /experiment="EXISTENCE:direct assay:GO:0031201 SNARE complex [PMID:9195974]" /experiment="EXISTENCE:direct assay:GO:0043325 phosphatidylinositol-3,4-bisphosphate binding [PMID:19502581]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:19502581]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:19502581]" /experiment="EXISTENCE:genetic interaction:GO:0031321 ascospore-type prospore assembly [PMID:19502581]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:11839791]" /experiment="EXISTENCE:mutant phenotype:GO:0031321 ascospore-type prospore assembly [PMID:19502581|PMID:16554438]" /experiment="EXISTENCE:physical interaction:GO:0005484 SNAP receptor activity [PMID:10924463|PMID:7954793]" /note="Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p; SSO1 has a paralog, SSO2, that arose from the whole genome duplication" /db_xref="GeneID:855844" /db_xref="SGD:S000006153" ORIGIN 1 msynnpyqle tpfeesyeld egssaigaeg hdfvgfmnki sqinrdldky dhtinqvdsl 61 hkrlltevne eqashlrhsl dnfvaqatdl qfklkneiks aqrdgihdtn kqaqaensrq 121 rflkliqdyr ivdsnykeen keqakrqymi iqpeatedev eaaisdvggq qifsqallna 181 nrrgeaktal aevqarhqel lkleksmael tqlfndmeel vieqqenvdv idknvedaql 241 dveqgvghtd kavksarkar knkircwliv faiivvvvvv vvvpavvktr // LOCUS NP_015093 1887 aa linear PLN 30-JUN-2025 DEFINITION trifunctional fatty acid synthase subunit FAS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015093 VERSION NP_015093.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184045.1 REFERENCE 1 (residues 1 to 1887) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1887) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1887) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1887) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1887) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1887) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1887) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11205. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1887 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1887 /product="trifunctional fatty acid synthase subunit FAS2" /EC_number="1.1.1.100" /EC_number="2.3.1.41" /EC_number="2.3.1.86" /calculated_mol_wt="206817" Region <16..73 /region_name="FabD" /note="Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]; COG0331" /db_xref="CDD:440100" Region 142..302 /region_name="Fas_alpha_ACP" /note="Fatty acid synthase subunit alpha Acyl carrier domain; pfam18325" /db_xref="CDD:465711" Region 332..534 /region_name="FAS_I_H" /note="Fatty acid synthase type I helical domain; pfam18314" /db_xref="CDD:465705" Region <679..1681 /region_name="FabG2" /note="3-oxoacyl-ACP reductase domain of yeast-type fatty acid synthase FAS1 [Lipid transport and metabolism]; COG4982" /db_xref="CDD:444006" Region 1765..1886 /region_name="pantethn_trn" /note="phosphopantetheine--protein transferase domain; TIGR00556" /db_xref="CDD:273136" CDS 1..1887 /gene="FAS2" /locus_tag="YPL231W" /coded_by="NM_001184045.1:1..5664" /experiment="EXISTENCE:direct assay:GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity [PMID:365179]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:6025308|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005835 fatty acid synthase complex [PMID:65153]" /experiment="EXISTENCE:mutant phenotype:GO:0004312 fatty acid synthase activity [PMID:65153]" /experiment="EXISTENCE:mutant phenotype:GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity [PMID:1100391]" /experiment="EXISTENCE:mutant phenotype:GO:0008897 holo-[acyl-carrier-protein] synthase activity [PMID:10785388]" /experiment="EXISTENCE:mutant phenotype:GO:0042759 long-chain fatty acid biosynthetic process [PMID:1735446]" /note="Alpha subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities" /db_xref="GeneID:855845" /db_xref="SGD:S000006152" ORIGIN 1 mkpeveqela hilltellay qfaspvrwie tqdvflkdfn tervveigps ptlagmaqrt 61 lknkyesyda alslhreilc yskdakeiyy tpdpselaak eepakeeapa ptpaasapap 121 aaaapapvaa aapaaaaaei adepvkasll lhvlvahklk ksldsipmsk tikdlvggks 181 tvqneilgdl gkefgttpek peetpleela etfqdtfsga lgkqssslls rlisskmpgg 241 ftitvarkyl qtrwglpsgr qdgvllvals nepaarlgse adakafldsm aqkyasivgv 301 dlssaasasg aagagaaaga amidagalee itkdhkvlar qqlqvlaryl kmdldngerk 361 flkekdtvae lqaqldylna elgeffvngv atsfsrkkar tfdsswnwak qsllslyfei 421 ihgvlknvdr evvseainim nrsndalikf meyhisntde tkgenyqlvk tlgeqlienc 481 kqvldvdpvy kdvakptgpk taidkngnit yseeprekvr klsqyvqema lggpitkesq 541 ptieedltrv ykaisaqadk qdissstrve feklysdlmk flesskeidp sqttqlagmd 601 vedaldkdst kevaslpnks tisktvssti pretipflhl rkktpagdwk ydrqlsslfl 661 dglekaafng vtfkdkyvli tgagkgsiga evlqgllqgg akvvvttsrf skqvtdyyqs 721 iyakygakgs tlivvpfnqg skqdvealie fiydtekngg lgwdldaiip faaipeqgie 781 lehidsksef ahrimltnil rmmgcvkkqk sargietrpa qvilpmspnh gtfggdgmys 841 esklsletlf nrwhseswan qltvcgaiig wtrgtglmsa nniiaegiek mgvrtfsqke 901 mafnllgllt pevvelcqks pvmadlnggl qfvpelkeft aklrkelvet sevrkavsie 961 talehkvvng nsadaayaqv eiqpraniql dfpelkpykq vkqiapaele glldlerviv 1021 vtgfaevgpw gsartrweme afgefslegc vemawimgfi syhngnlkgr pytgwvdskt 1081 kepvddkdvk akyetsileh sgirliepel fngynpekke miqeviveed lepfeasket 1141 aeqfkhqhgd kvdifeipet geysvkllkg atlyipkalr fdrlvagqip tgwnaktygi 1201 sddiisqvdp itlfvlvsvv eafiasgitd pyemykyvhv sevgncsgsg mggvsalrgm 1261 fkdrfkdepv qndilqesfi ntmsawvnml lisssgpikt pvgacatsve svdigvetil 1321 sgkaricivg gyddfqeegs fefgnmkats ntleefehgr tpaemsrpat ttrngfmeaq 1381 gagiqiimqa dlalkmgvpi ygivamaata tdkigrsvpa pgkgilttar ehhssvkyas 1441 pnlnmkyrkr qlvtreaqik dwveneleal kleaeeipse dqnefllert reihneaesq 1501 lraaqqqwgn dfykrdpria plrgalatyg ltiddlgvas fhgtstkand knesatinem 1561 mkhlgrsegn pvigvfqkfl tghpkgaaga wmmngalqil nsgiipgnrn adnvdkileq 1621 feyvlypskt lktdgvravs itsfgfgqkg gqaivvhpdy lygaitedry neyvakvsar 1681 eksaykffhn gmiynklfvs kehapytdel eedvyldpla rvskdkksgs ltfnskniqs 1741 kdsyinanti etakmienmt kekvsnggvg vdvelitsin vendtfiern ftpqeieycs 1801 aqpsvqssfa gtwsakeavf kslgvkslgg gaalkdieiv rvnknapave lhgnakkaae 1861 eagvtdvkvs ishddlqava vavstkk // LOCUS NP_015094 391 aa linear PLN 30-JUN-2025 DEFINITION Usv1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015094 VERSION NP_015094.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184044.1 REFERENCE 1 (residues 1 to 391) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 391) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 391) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 391) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 391) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11206. Method: conceptual translation. FEATURES Location/Qualifiers source 1..391 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..391 /product="Usv1p" /calculated_mol_wt="43387" Region 11..389 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 43..66 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 74..91 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..391 /gene="USV1" /locus_tag="YPL230W" /gene_synonym="NSF1" /coded_by="NM_001184044.1:1..1176" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18667581|PMID:27663510]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667|PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:18667581]" /experiment="EXISTENCE:mutant phenotype:GO:0071472 cellular response to salt stress [PMID:18667581]" /note="Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis; USV1 has a paralog, RGM1, that arose from the whole genome duplication" /db_xref="GeneID:855871" /db_xref="SGD:S000006151" ORIGIN 1 menttnrnta gvltssngnf atnsvaastp krsksarrkt fkctgydgct msftraehla 61 rhirkhtgek pfqcpaclkf fsrvdnlkqh resvhahknh hstsshqrkp sssslsssss 121 asssssasss tsysdpyrkt ninsgnmpmm aenekapqii hsspefitst rsippisprs 181 iyntqrqqqh qqqqhqqapy yfpshpitds yyqyplpsnn ntinylpsvd vqyplnvsps 241 stshpasevi issfpprsmp stsfkykdsa dfqarttmnk ynirpsninv ntsninnhld 301 sfsppfspst tvaeakpiil pqyqqafsqp pngnknnnms ssknggkgge nfkntddrnd 361 nnnkkrsetl sesdisvntn kkrlsvdyil t // LOCUS NP_015095 206 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL229W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015095 VERSION NP_015095.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184043.1 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11207. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..206 /product="uncharacterized protein" /calculated_mol_wt="23129" CDS 1..206 /locus_tag="YPL229W" /coded_by="NM_001184043.1:1..621" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; not an essential gene; YPL229W has a paralog, YMR181C, that arose from the whole genome duplication" /db_xref="GeneID:855872" /db_xref="SGD:S000006150" ORIGIN 1 mmpyntppni qepmnfassn pfgiipdals fqnfkydrlq qqqqqqqqqq qnrtasslqq 61 pqqqqpispp lflvgagtse nsnlnknant stippllfsr ssqhyvvpdi dhssiiyknn 121 icksfkddlf fcprsllsle eqqacekmdr ltaeqmslyh qntqsssnpg smsssppnsa 181 ssifnsrpkf npytsqsfnp lesvqe // LOCUS NP_015096 549 aa linear PLN 30-JUN-2025 DEFINITION polynucleotide 5'-phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015096 VERSION NP_015096.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184042.1 REFERENCE 1 (residues 1 to 549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 549) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11208. Method: conceptual translation. FEATURES Location/Qualifiers source 1..549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..549 /product="polynucleotide 5'-phosphatase" /EC_number="3.6.1.74" /calculated_mol_wt="61719" Region 278..497 /region_name="mRNA_triPase" /note="mRNA capping enzyme, beta chain; pfam02940" /db_xref="CDD:397201" Site order(283..284,354,358,463,470,522,525..526,528..529) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:143621" Site order(305,307,377,393,405,409,433,454,456,458,471,492,494, 496) /site_type="active" /db_xref="CDD:143621" Site order(305,307,471,494,496) /site_type="other" /note="putative metal binding residues [ion binding]" /db_xref="CDD:143621" Site order(305,377,393,405,409,433,456,458,496) /site_type="other" /note="gamma-phosphate binding site [chemical binding]" /db_xref="CDD:143621" Site order(305,307,309) /site_type="active" /note="signature motif [active]" /db_xref="CDD:143621" Site 454..456 /site_type="other" /note="motif B" /db_xref="CDD:143621" Site 492..496 /site_type="other" /note="motif C" /db_xref="CDD:143621" CDS 1..549 /gene="CET1" /locus_tag="YPL228W" /gene_synonym="CES5" /coded_by="NM_001184042.1:1..1650" /experiment="EXISTENCE:direct assay:GO:0004651 polynucleotide 5'-phosphatase activity [PMID:17707331|PMID:9345280]" /experiment="EXISTENCE:genetic interaction:GO:0031533 mRNA capping enzyme complex [PMID:9710603]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:24172134]" /experiment="EXISTENCE:mutant phenotype:GO:1900182 positive regulation of protein localization to nucleus [PMID:24205062]" /experiment="EXISTENCE:physical interaction:GO:0006370 7-methylguanosine mRNA capping [PMID:9345280]" /experiment="EXISTENCE:physical interaction:GO:0031533 mRNA capping enzyme complex [PMID:9710603]" /note="RNA 5'-triphosphatase involved in mRNA 5' capping; subunit of mRNA capping enzyme, which is a heterotetramer composed of a Cet1p homodimer and two molecules of guanylyltransferase Ceg1p; Cet1p also has a role in regulation of RNAPII pausing at promoter-proximal sites; interaction between Cet1p and Ceg1p is required for Ceg1p nuclear import; mammalian enzyme is single bifunctional polypeptide; human homolog RNGTT can complement yeast cet1 null mutant" /db_xref="GeneID:855873" /db_xref="SGD:S000006149" ORIGIN 1 msytdnppqt kralslddlv nhdenekvkl qklseaangs rpfaenlesd inqtetgqaa 61 pidnykestg hgshsqkpks rkssnddeet dtddemgasg einfdsemdf dydkqhrnll 121 sngsppmndg sdanaklekp sddsihqnsk sdeeqripkq gnegniasny itqvplqkqk 181 qtekkiagna vgsvvkkeee anaavdnife ekatlqskkn nikrdlevln eisasskpsk 241 yrnvpiwaqk wkptikalqs invkdlkidp sflniipddd ltksvqdwvy atiysiapel 301 rsfielemkf gviidakgpd rvnppvssqc vfteldahlt pnidaslfke lskyirgise 361 vtentgkfsi iesqtrdsvy rvglstqrpr flrmstdikt grvgqfiekr hvaqlllysp 421 kdsydvkisl nlelpvpdnd ppekyksqsp isertkdrvs yihndsctri ditkvenhnq 481 nsksrqsett heveleintp allnafdnit ndskeyasli rtflnngtii rrklsslsye 541 ifegskkvm // LOCUS NP_015097 334 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-phosphate beta-glucosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015097 VERSION NP_015097.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184041.1 REFERENCE 1 (residues 1 to 334) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 334) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 334) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 334) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 334) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11209. Method: conceptual translation. FEATURES Location/Qualifiers source 1..334 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..334 /product="dolichyl-phosphate beta-glucosyltransferase" /EC_number="2.4.1.117" /calculated_mol_wt="38216" Region 77..302 /region_name="DPG_synthase" /note="DPG_synthase is involved in protein N-linked glycosylation; cd04188" /db_xref="CDD:133031" Site order(80,82,172) /site_type="active" /note="Ligand binding site [active]" /db_xref="CDD:133031" Site order(114,171..172) /site_type="active" /note="Putative Catalytic site [active]" /db_xref="CDD:133031" Site 170..172 /site_type="active" /note="DXD motif [active]" /db_xref="CDD:133031" CDS 1..334 /gene="ALG5" /locus_tag="YPL227C" /coded_by="NM_001184041.1:1..1005" /experiment="EXISTENCE:direct assay:GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity [PMID:8076653]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:9560251]" /note="UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant" /db_xref="GeneID:855874" /db_xref="SGD:S000006148" ORIGIN 1 mralrflien rntvfftllv alvlslyllv ylfshtprpp ypeelkyiai dekghevsra 61 lpnlnehqdd eeiflsvvip synetgrill mltdaisflk ekygsrweiv ivddgstdnt 121 tqyclkicke qfklnyeqfr iikfsqnrgk ggavrqgflh irgkyglfad adgaskfsdv 181 eklidaiski etsstdlktt kpavaigsra hmvnteavik rsmirnclmy gfhtlvfifg 241 irsikdtqcg fklfnraail kifpylhteg wifdveilil airkriqiee ipiswhevdg 301 skmalaidsi kmakdlviir mayllgiyrd nkkc // LOCUS NP_015098 1196 aa linear PLN 30-JUN-2025 DEFINITION New1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015098 VERSION NP_015098.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184040.1 REFERENCE 1 (residues 1 to 1196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1196) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11210. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1196 /product="New1p" /calculated_mol_wt="134200" Region 183..214 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 224..253 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 264..291 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 575..1108 /region_name="Uup" /note="ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; COG0488" /db_xref="CDD:440254" CDS 1..1196 /gene="NEW1" /locus_tag="YPL226W" /coded_by="NM_001184040.1:1..3591" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:31299085]" /experiment="EXISTENCE:mutant phenotype:GO:0006449 regulation of translational termination [PMID:31299085]" /experiment="EXISTENCE:mutant phenotype:GO:0008079 translation termination factor activity [PMID:31299085]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:19806183]" /note="Translation termination and ribosome biogenesis factor; ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction" /db_xref="GeneID:855875" /db_xref="SGD:S000006147" ORIGIN 1 mppkkfkdln sflddqpkdp nlvaspfggy fknpaadags nnaskkssyq qqrnwkqggn 61 yqqggyqsyn snynnynnyn nynnynnynn ynkyngqgyq kstykqsavt pnqsgtptps 121 asttsltsln eklsnleltp isqflskipe cqsitdcknq ikliieefgk egnstgekie 181 ewkivdvlsk fikpknpslv resamliisn iaqffsgkpp qeayllpffn valdcisdke 241 ntvkraaqha idsllncfpm ealtcfvlpt ildylssgak wqakmaalsv vdriredsan 301 dlleltfkda vpvltdvatd fkpelakqgy ktlldyvsil dnldlspryk livdtlqdps 361 kvpesvksls svtfvaevte pslsllvpil nrslnlssss qeqlrqtviv venltrlvnn 421 rneiesfipl llpgiqkvvd taslpevrel aekalnvlke ddeadkenkf sgrltleegr 481 dflldhlkdi kaddscfvkp ymndetviky mskiltvdsn vndwkrledf ltavfggsds 541 qrefvkqdfi hnlralfyqe keradedegi eivntdfsla ygsrmllnkt nlrllkghry 601 glcgrngagk stlmraiang qldgfpdkdt lrtcfvehkl qgeegdldlv sfialdeelq 661 stsreeiaaa lesvgfdeer raqtvgslsg gwkmklelar amlqkadill ldeptnhldv 721 snvkwleeyl lehtditsli vshdsgfldt vctdiihyen kklayykgnl aafveqkpea 781 ksyytltdsn aqmrfpppgi ltgvksntra vakmtdvtfs ypgaqkpsls hvscslslss 841 rvaclgpnga gkstlikllt gelvpnegkv ekhpnlrigy iaqhalqhvn ehkektanqy 901 lqwryqfgdd revllkesrk isedekemmt keididdgrg kraieaivgr qklkksfqye 961 vkwkywkpky nswvpkdvlv ehgfeklvqk fddheasreg lgyrelipsv itkhfedvgl 1021 dseianhtpl gslsggqlvk vviagamwnn phllvldept nyldrdslga lavairdwsg 1081 gvvmishnne fvgalcpeqw ivengkmvqk gsaqvdqskf edggnadavg lkasnlakps 1141 vddddspani kvkqrkkrlt rnekklqaer rrlryiewls spkgtpkpvd tddeed // LOCUS NP_015099 146 aa linear PLN 30-JUN-2025 DEFINITION ribosome-associated Tef1p biogenesis chaperone CHP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015099 VERSION NP_015099.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184039.1 REFERENCE 1 (residues 1 to 146) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 146) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 146) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 146) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 146) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11211. Method: conceptual translation. FEATURES Location/Qualifiers source 1..146 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..146 /product="ribosome-associated Tef1p biogenesis chaperone CHP1" /calculated_mol_wt="17314" Region 15..142 /region_name="Polysacc_synt_4" /note="Polysaccharide biosynthesis; pfam04669" /db_xref="CDD:368048" CDS 1..146 /gene="CHP1" /locus_tag="YPL225W" /coded_by="NM_001184039.1:1..441" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:38360885]" /experiment="EXISTENCE:direct assay:GO:0044183 protein folding chaperone [PMID:38360885]" /experiment="EXISTENCE:direct assay:GO:0051083 'de novo' cotranslational protein folding [PMID:38360885]" /experiment="EXISTENCE:direct assay:GO:0051787 misfolded protein binding [PMID:38360885]" /experiment="EXISTENCE:direct assay:GO:0061770 translation elongation factor binding [PMID:38360885]" /experiment="EXISTENCE:direct assay:GO:1990593 nascent polypeptide-associated complex binding [PMID:38360885]" /note="Chaperone for eEF1A; ribosome-associated chaperone dedicated to facilitating high-level expression of eEF1A; transiently binds nascent GTPase domain of eEF1A as soon as it emerges from ribosome tunnel; forms complex with NAC by binding UBA domain of Egd2p; inactivation results in disturbed proteostasis and Hsf1p activation due to abberant eEF1A biogenesis; overlapping phenotypes support notion that Chp1p functions in same eEF1A biogenesis pathway as chaperone Zpr1p-Aim29p" /db_xref="GeneID:855876" /db_xref="SGD:S000006146" ORIGIN 1 mstfnaetad nlediekqfa vvaveqaety wklltsvpgs klrltkfdde iyenfmerfp 61 eykdvervkk fteeelktke akerwrkfft ifekkiedyn fgtllrtdas aeygqfttcf 121 vvrlqfyafe iarnkhglnd wivgqk // LOCUS NP_015100 484 aa linear PLN 30-JUN-2025 DEFINITION Mmt2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015100 VERSION NP_015100.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184038.2 REFERENCE 1 (residues 1 to 484) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 484) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 484) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 484) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 484) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11212. On Apr 26, 2011 this sequence version replaced NP_015100.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..484 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..484 /product="Mmt2p" /calculated_mol_wt="52303" Region 129..445 /region_name="FieF" /note="Divalent metal cation (Fe/Co/Zn/Cd) efflux pump [Inorganic ion transport and metabolism]; COG0053" /db_xref="CDD:439823" CDS 1..484 /gene="MMT2" /locus_tag="YPL224C" /gene_synonym="MFT2" /coded_by="NM_001184038.2:1..1455" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:9353309]" /experiment="EXISTENCE:genetic interaction:GO:0006879 intracellular iron ion homeostasis [PMID:9353309]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:9353309]" /note="Putative metal transporter involved in mitochondrial iron accumulation; MMT2 has a paralog, MMT1, that arose from the whole genome duplication" /db_xref="GeneID:855877" /db_xref="SGD:S000006145" ORIGIN 1 mlrisidsik qfgsfvpgyn ntsyhaagra irtsslystm isanprrclh sskllnkegq 61 eegyneqlis kmssqngsns rqnesegkke gkassvksll qhthshshth mhdnpllsln 121 vqqikknpgv ritwiglasn vgmavgkfvg gitfhsqall adsvhalsdl vsdfltlfsv 181 qyasrkptse ypygygkvet vgslavstil amagisigws slcaivgpvi phailesmag 241 ligethshsq sltqqatnvn avwiaagsil vkewvfqatk kvaiqtnsnv lmanawhhrv 301 dsltslvalv aitssyffni qsldnlgglv vsgliiktgg qgilsslkel vdqsipptdp 361 ryleiesvik dsigslktdl dlkqslhvrd ltilasgpnl ratttlevpv lhsgqevgir 421 flenaistir edlrmkvpnv gkvdvefvdv tsdskgdleh shdtkstnht hthsdsadth 481 thkh // LOCUS NP_015101 168 aa linear PLN 30-JUN-2025 DEFINITION Gre1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015101 VERSION NP_015101.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184037.1 REFERENCE 1 (residues 1 to 168) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 168) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 168) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 168) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11213. Method: conceptual translation. FEATURES Location/Qualifiers source 1..168 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..168 /product="Gre1p" /calculated_mol_wt="18894" CDS 1..168 /gene="GRE1" /locus_tag="YPL223C" /coded_by="NM_001184037.1:1..507" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /note="Hydrophilin essential in desiccation-rehydration process; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; GRE1 has a paralog, SIP18, that arose from the whole genome duplication" /db_xref="GeneID:855878" /db_xref="SGD:S000006144" ORIGIN 1 msnllnkfad klhgndhder yeddnddqtr qqrhekhqqr efrnqgskad pygeenqgnf 61 pqrqqpqsnl ggntqfggnd fqqqttdyta gtgggtytqt yretntqgql dddedddflt 121 sgqqqkqgrt rgaqsnryqs snigsgrrdl sgsgndeydd dsgnqgvw // LOCUS NP_015102 688 aa linear PLN 30-JUN-2025 DEFINITION Fmp40p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015102 VERSION NP_015102.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184036.1 REFERENCE 1 (residues 1 to 688) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 688) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 688) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 688) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 688) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11214. Method: conceptual translation. FEATURES Location/Qualifiers source 1..688 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..688 /product="Fmp40p" /calculated_mol_wt="78182" Region 50..648 /region_name="SelO" /note="Protein adenylyltransferase SelO; pfam02696" /db_xref="CDD:426929" CDS 1..688 /gene="FMP40" /locus_tag="YPL222W" /coded_by="NM_001184036.1:1..2067" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:30270044|PMID:14576278|PMID:24769239|PMID:14562095|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0018117 protein adenylylation [PMID:30270044]" /experiment="EXISTENCE:direct assay:GO:0045454 cell redox homeostasis [PMID:30270044]" /experiment="EXISTENCE:direct assay:GO:0070733 AMPylase activity [PMID:30270044]" /note="Mitochondrial AMPylator in the pseudokinase selenoprotein-O family; role in the oxidative stress response, transferring AMP from ATP to protein substrates (AMPylation) involved in redox homeostasis; regulates S-glutathionylation levels; proposed involvement in the environmental stress response" /db_xref="GeneID:855879" /db_xref="SGD:S000006143" ORIGIN 1 mgekrtiika lknsaashfi kkltadtsls siqeainvvq qynatdpvrl klfhtprmvs 61 qgahfafclp tkkphykpll lsqnaldefn lvqdqdleki lsgekvyysd sifpystvys 121 gfqfgsfaaq lgdgrvvnlf dlkdkcsgqw qtfqlkgagm tpfsrfadgk avlrssiref 181 imsealhsig ipstramqlt llpgtkaqrr nqepcavvcr fapswirlgn fnlfrwrhdl 241 kgliqlsdyc ieelfaggtq fegkpdfnif krdffpdtet kideqvekde tevstmtgdn 301 istlskydef frhvvslnan tvahwqaygf angvlntdnt simgltidyg pfafldkfep 361 sftpnhddta krysfanqps iiwwnlqqfa kdlacllgpe ardlelllkg elnsvddale 421 ktmiervqkl velsaneyky vfttryaqim sqrlgvdldl ekcmsstnlk diehaaekak 481 efcdvivepl ldilqatkvd ynnffihlqn ykgpffikdk sdtatlfgaf deeylgmffn 541 skqlqqmaet eeafaagekv fdangelrll neklqeirnw tqdyltlvpp tetaarasla 601 kkanplfvpr swvleevvdd lmysqrdglq dpsseldtsa lkklylmsvn pydrtkwdvt 661 lrpeletkwa dlshqddakf mmqascss // LOCUS NP_015103 793 aa linear PLN 30-JUN-2025 DEFINITION flavin adenine dinucleotide transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_015103 VERSION NP_015103.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184035.1 REFERENCE 1 (residues 1 to 793) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 793) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 793) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 793) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 793) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11215. Method: conceptual translation. FEATURES Location/Qualifiers source 1..793 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..793 /product="flavin adenine dinucleotide transporter" /calculated_mol_wt="89160" Region 26..161 /region_name="TRP_N" /note="ML-like domain; pfam14558" /db_xref="CDD:434037" Site order(31,44,47,49,58,60,62,74,76,78,90,101,108,128,130,132, 134,148,151,153,155) /site_type="other" /note="putative lipid binding cavity [chemical binding]" /db_xref="CDD:238454" Region 166..597 /region_name="TRP" /note="Transient receptor potential (TRP) ion channel; pfam06011" /db_xref="CDD:428720" CDS 1..793 /gene="FLC1" /locus_tag="YPL221W" /coded_by="NM_001184035.1:1..2382" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16717099]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0030148 sphingolipid biosynthetic process [PMID:27462707]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0009272 fungal-type cell wall biogenesis [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0015230 FAD transmembrane transporter activity [PMID:16717099]" /experiment="EXISTENCE:mutant phenotype:GO:0015883 FAD transport [PMID:16717099]" /note="Flavin adenine dinucleotide transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC1 has a paralog, FLC3, that arose from the whole genome duplication" /db_xref="GeneID:855880" /db_xref="SGD:S000006142" ORIGIN 1 mqvlvtlwcl ictclvlpva akkrtltass lvtcmensql sansfdvsfs pddrslhydl 61 dmttqidsyi yayvdvyayg fkiitenfdv csmgwkqfcp vhpgniqids ieyiaqkyvk 121 mipgiayqvp didayvrlni ynnvsenlac iqvffsngkt vsqigvkwvt aviagigllt 181 savlstfgns taashisant mslflyfqsv avvamqhvds vppiaaawse nlawsmglir 241 itfmqkifrw yveatggsas lyltattmsv ltqrgldylk ntsvykraen vlygnsntli 301 frgikrmgyr mkientaivc tgftffvlcg yflagfimac kysielcirc gwmrsdrfyq 361 frknwrsvlk gsllryiyig ftqltilsfw efterdsagv iviaclfivl scglmawaay 421 rtiffasksv emynnpaall ygdeyvlnky gffytmfnak hywwnalltt yilvkalfvg 481 faqasgktqa laifiidlay fvaiirykpy ldrptnivni fictvtlvns flfmffsnlf 541 nqkyavsaim gwvffimnaa fslllllmil afttiilfsk npdsrfkpak ddrasfqkha 601 iphegalnks vanelmalgn vakdhtenwe yelksqegks ednlfgveyd dektgtnsen 661 aessskettr ptfsekvlrs lsikrnkskl gsfkrsapdk itqqevspdr assspnsksy 721 pgvshtrqes eannglinay edeqfslmep siledaasst qmhampardl slssvanaqd 781 vtkkanildp dyl // LOCUS NP_015104 217 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL1 RPL1A [Saccharomyces cerevisiae S288C]. ACCESSION NP_015104 VERSION NP_015104.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184034.1 REFERENCE 1 (residues 1 to 217) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 217) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 217) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 217) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 217) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11216. Method: conceptual translation. FEATURES Location/Qualifiers source 1..217 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..217 /product="60S ribosomal protein uL1 RPL1A" /calculated_mol_wt="24355" Region 1..217 /region_name="Ribosomal_L1" /note="Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; cl00322" /db_xref="CDD:469720" Site order(26..28,31,33,35,37,162,164,166,210..211,213) /site_type="other" /note="mRNA/rRNA interface [nucleotide binding]" /db_xref="CDD:238235" CDS 1..217 /gene="RPL1A" /locus_tag="YPL220W" /gene_synonym="PUB2; SSM1" /coded_by="NM_001184034.1:1..654" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:31439809]" /note="Ribosomal 60S subunit protein L1A; N-terminally acetylated; homologous to mammalian ribosomal protein L10A and bacterial L1; RPL1A has a paralog, RPL1B, that arose from the whole genome duplication; rpl1a rpl1b double null mutation is lethal; ribosomes containing Rpl1b are more efficient in translation of respiration-related proteins" /db_xref="GeneID:855881" /db_xref="SGD:S000006141" ORIGIN 1 mskitssqvr ehvkellkys netkkrnfle tvelqvglkn ydpqrdkrfs gslklpncpr 61 pnmsicifgd afdvdraksc gvdamsvddl kklnknkkli kklskkynaf iasevlikqv 121 prllgpqlsk agkfptpvsh nddlygkvtd vrstikfqlk kvlclavavg nvemeedvlv 181 nqilmsvnff vsllkknwqn vgslvvkssm gpafrly // LOCUS NP_015105 492 aa linear PLN 30-JUN-2025 DEFINITION Pcl8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015105 VERSION NP_015105.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184033.1 REFERENCE 1 (residues 1 to 492) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 492) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 492) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 492) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11217. Method: conceptual translation. FEATURES Location/Qualifiers source 1..492 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..492 /product="Pcl8p" /calculated_mol_wt="55300" Region 362..469 /region_name="CYCLIN_ScPCL7-like" /note="cyclin box found in Saccharomyces cerevisiae PHO85 cyclin-7 (ScPCL7) and similar proteins; cd20558" /db_xref="CDD:410261" Site order(380,382,429..435,437..439,453,456..457,460..461, 464..469) /site_type="other" /note="CDK interface [polypeptide binding]" /db_xref="CDD:410261" CDS 1..492 /gene="PCL8" /locus_tag="YPL219W" /coded_by="NM_001184033.1:1..1479" /experiment="EXISTENCE:genetic interaction:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:9584169]" /experiment="EXISTENCE:mutant phenotype:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:9584169]" /note="Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication" /db_xref="GeneID:855882" /db_xref="SGD:S000006140" ORIGIN 1 mandqdpnks lindaltrsm sefydddddn dsdmcrande gedvfdlplk vgvsqsrnfs 61 evndvldpls slhgpskkvr feqqkqqqqh qqlhndfntd fnlkspsskk mgveqliqsa 121 neindylann idkvnsfnse llsgsgklpg rvksdtatqg tgrldsmsnf alsdteldnd 181 ddnylldpla nassttptve hhgyslldka lstsdkekiy tnkvnsnsqi dtdnhshesg 241 nttnnetden esseildytk fdsfpyppss apngeppdlk vlsieceqen ekelrrisll 301 ldhyesipki pelsddeals kfrenielil qlskkindna ntlaissedp qkfvnfvmkn 361 ppslsfrdfi driqnkcmfg avvylgatyl lqlvfltrde mdgpiklkak lqedqahrii 421 istiriatkl ledfvhsqny ickvfgiskr lltkleisfm asvnfdglmi tceklektlh 481 ilddtrqalg nt // LOCUS NP_015106 190 aa linear PLN 30-JUN-2025 DEFINITION Arf family GTPase SAR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015106 VERSION NP_015106.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184032.1 REFERENCE 1 (residues 1 to 190) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 190) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 190) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 190) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 190) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11218. Method: conceptual translation. FEATURES Location/Qualifiers source 1..190 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..190 /product="Arf family GTPase SAR1" /calculated_mol_wt="21320" Region 7..190 /region_name="SAR" /note="Sar1p-like members of the Ras-family of small GTPases; smart00178" /db_xref="CDD:197556" CDS 1..190 /gene="SAR1" /locus_tag="YPL218W" /coded_by="NM_001184032.1:1..573" /experiment="EXISTENCE:direct assay:GO:0003400 regulation of COPII vesicle coating [PMID:14627716|PMID:15665868]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:8419365|PMID:9756629]" /experiment="EXISTENCE:direct assay:GO:0016050 vesicle organization [PMID:16122427]" /experiment="EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:8004676]" /experiment="EXISTENCE:direct assay:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:27101143]" /experiment="EXISTENCE:direct assay:GO:0070971 endoplasmic reticulum exit site [PMID:22675024]" /experiment="EXISTENCE:genetic interaction:GO:0000266 mitochondrial fission [PMID:27101143]" /experiment="EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:31406088]" /experiment="EXISTENCE:mutant phenotype:GO:0007006 mitochondrial membrane organization [PMID:27101143]" /experiment="EXISTENCE:mutant phenotype:GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site [PMID:27101143]" /experiment="EXISTENCE:mutant phenotype:GO:0061024 membrane organization [PMID:27101143]" /note="ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics" /db_xref="GeneID:855883" /db_xref="SGD:S000006139" ORIGIN 1 magwdifgwf rdvlaslglw nkhgkllflg ldnagkttll hmlkndrlat lqptwhptse 61 elaignikft tfdlgghiqa rrlwkdyfpe vngivflvda adperfdear veldalfnia 121 elkdvpfvil gnkidapnav seaelrsalg llnttgsqri egqrpvevfm csvvmrngyl 181 eafqwlsqyi // LOCUS NP_015107 1183 aa linear PLN 30-JUN-2025 DEFINITION GTPase BMS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015107 VERSION NP_015107.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184031.1 REFERENCE 1 (residues 1 to 1183) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1183) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1183) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1183) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1183) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11219. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1183 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1183 /product="GTPase BMS1" /calculated_mol_wt="135441" Region 1..1182 /region_name="BMS1" /note="GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]; COG5192" /db_xref="CDD:227519" CDS 1..1183 /gene="BMS1" /locus_tag="YPL217C" /coded_by="NM_001184031.1:1..3552" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:16307926]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:16307926]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:16307926]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11565749]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11565749]" /experiment="EXISTENCE:mutant phenotype:GO:0003924 GTPase activity [PMID:16307926]" /experiment="EXISTENCE:mutant phenotype:GO:0005525 GTP binding [PMID:16307926]" /note="GTPase required for ribosomal subunit synthesis and rRNA processing; required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p" /db_xref="GeneID:855884" /db_xref="SGD:S000006138" ORIGIN 1 meqsnkqhrk akekntakkk lhtqghnaka favaapgkma rtmqrssdvn erklhvpmvd 61 rtpeddpppf ivavvgppgt gkttlirslv rrmtkstlnd iqgpitvvsg khrrltflec 121 paddlnamid iakiadlvll lidgnfgfem etmeflniaq hhgmprvlgv athldlfksq 181 stlraskkrl khrfwtevyq gaklfylsgv ingrypdrei lnlsrfisvm kfrplkwrne 241 hpymladrft dlthpeliet qglqidrkva iygylhgtpl psapgtrvhi agvgdfsvaq 301 ieklpdpcpt pfyqqklddf erekmkeeak angeittast trrrkrlddk dkliyapmsd 361 vggvlmdkda vyidigkkne epsfvpgqer gegeklmtgl qsveqsiaek fdgvglqlfs 421 ngtelhevad hegmdvesge esieddegks kgrtslrkpr iygkpvqeed adidnlpsde 481 epytndddvq dseprmveid fnntgeqgae klaletdsef eesedefswe rtaanklkkt 541 eskkrtwnig kliymdnisp eecirrwrge dddskdesdi eedvdddffr kkdgtvtkeg 601 nkdhavdlek fvpyfdtfek lakkwksvda ikerflgagi lgndnktksd sneggeelyg 661 dfedledgnp seqaednsdk esededened tngdddnsft nfdaeekkdl tmeqeremna 721 akkeklraqf eieegenfke ddenneydtw yelqkakisk qleinnieyq emtpeqrqri 781 egfkagsyvr ivfekvpmef vknfnpkfpi vmggllptei kfgivkarlr rhrwhkkilk 841 tndplvlslg wrrfqtlpiy tttdsrtrtr mlkytpehty cnaafygplc spntpfcgvq 901 ivansdtgng friaatgive eidvnieivk klklvgfpyk ifkntafikd mfssamevar 961 fegaqiktvs girgeikral skpeghyraa fedkilmsdi vilrswypvr vkkfynpvts 1021 lllkektewk glrltgqira amnletpsnp dsayhkierv erhfnglkvp kavqkelpfk 1081 sqihqmkpqk kktymakrav vlggdekkar sfiqkvltis kakdskrkeq kasqrkerlk 1141 klakmeeeks qrdkekkkey faqngkrttm ggddesrprk mrr // LOCUS NP_015108 1102 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL216W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015108 VERSION NP_015108.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184030.1 REFERENCE 1 (residues 1 to 1102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1102) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11220. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1102 /product="uncharacterized protein" /calculated_mol_wt="128003" Region 26..124 /region_name="WAC_Acf1_DNA_bd" /note="ATP-utilizing chromatin assembly and remodelling N-terminal; pfam10537" /db_xref="CDD:463140" Region 375..435 /region_name="DDT" /note="domain in different transcription and chromosome remodeling factors; smart00571" /db_xref="CDD:214726" CDS 1..1102 /locus_tag="YPL216W" /coded_by="NM_001184030.1:1..3309" /note="hypothetical protein; not an essential gene; YPL216W has a paralog, ITC1, that arose from the whole genome duplication" /db_xref="GeneID:855885" /db_xref="SGD:S000006137" ORIGIN 1 mvllnrrkiq pkeigqsads fsetpwvike sserindyds dlkkldfykr diftceisgk 61 dglsyfkalk seeqhrekvr yllpkelrka ianfanfspi rkvghlvesa fqrfsnrffi 121 gdtvclktiq knalitykeg epnlvespti ennvtlflvk dvfqsngmme sekgeisapk 181 lslylitecl nreskgaali vgqneikrpe shfskfiiac flneilikvs nkehapwrvk 241 qeyierydvn pkcspnmidy lpdrmnssss elytpltipp esdvepadwk etsetsetse 301 tslskikaid deisvsfdhi ydnvnslayn dlkgtvddke lpftgpsipf enisyldssl 361 eyknidqkwf kecsqfpter llvvyqflsf fgrfiglshf nfdqflttik ctspealvde 421 yvkinflkty nskgsftnek prneiynqvt ssnvsqreka nvfnadesqr ipsnftrnqk 481 mrkfitdkst efvmysifkg kplknddmef qsyekvnily idivcslmcl mtdnepdwnc 541 nlmdnwteek rkeegnktei diaiekclny gdtswvkllh nknfsngnwl icllgilqqn 601 thmiaysdva kcitkkilpl smnfvnlgde lwdnfrkrls ikdkidvlwv lvdfasnfss 661 yikelvdkvp klcngirlkl dsakkeyikl krqlktltkn rvklhsnvsm nrygsdeckg 721 kvnalkvkia ylmediafle akliqsdikr leilgkdrng nryywmdsng sssaisekne 781 elynccflwv qgpseadinf cldvdveslk kwellakakg tayatkevfs ifrstdgsyy 841 qiaqgenfmi insngilmrp tipafidkki isetpeklll shhqwaffnd iedihmlvdr 901 lddlrenegq lkkaltskmd rievsykqqf kikrriecde tfkknhkllk nneftfpelk 961 riettctsng qhfsnmekis kklsrtkndl vleailkdva hlgecerall kkqqnliypl 1021 nfhfeqlrti dlefivetkr krqediltkl lnhqrykhis hvsgygissq rvdkaahldv 1081 qgileeiecq lisrrredee rn // LOCUS NP_015109 335 aa linear PLN 30-JUN-2025 DEFINITION Cbp3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015109 VERSION NP_015109.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184029.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11221. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..335 /product="Cbp3p" /calculated_mol_wt="38953" Region 146..286 /region_name="Ubiq_cyt_C_chap" /note="Ubiquinol-cytochrome C chaperone; pfam03981" /db_xref="CDD:461119" CDS 1..335 /gene="CBP3" /locus_tag="YPL215W" /coded_by="NM_001184029.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:29475949]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:11522252]" /experiment="EXISTENCE:direct assay:GO:0005761 mitochondrial ribosome [PMID:21670217]" /experiment="EXISTENCE:direct assay:GO:0031966 mitochondrial membrane [PMID:11522252]" /experiment="EXISTENCE:direct assay:GO:0043022 ribosome binding [PMID:21670217]" /experiment="EXISTENCE:mutant phenotype:GO:0034551 mitochondrial respiratory chain complex III assembly [PMID:11522252|PMID:15759116]" /experiment="EXISTENCE:mutant phenotype:GO:0070131 positive regulation of mitochondrial translation [PMID:21670217]" /experiment="EXISTENCE:physical interaction:GO:0043022 ribosome binding [PMID:21670217]" /experiment="EXISTENCE:physical interaction:GO:0061671 Cbp3p-Cbp6 complex [PMID:21670217]" /note="Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex; Cbp3p-Cbp6p complex is sequestered if assembly of Complex III is blocked, downregulating COB mRNA translation" /db_xref="GeneID:855886" /db_xref="SGD:S000006136" ORIGIN 1 mmsvnrftsg rlpvflrksp fyysraylhq tcvfkqnket aqdspellak sshlnskpld 61 vsnkapvkta qnkiplahsk yesskyelpk wkealgelvi rafhldmdrv ragpvagsyy 121 ykickeqglq yedeplseta kyfyedlklp rtfsqwfqit vlhewilfvr mrampfkygr 181 nyqqklvdrt fsdielrlfe emkvnsgria dqylkdfntq lrgaifayde gfatddgtla 241 tavwrnlfgg rknidmvhle svvryiysql yvlsrlsdre fatgkfkfvp pgvkvekltp 301 kqeeelkakt iakyealdkd pktlpsersr lsytn // LOCUS NP_015110 540 aa linear PLN 30-JUN-2025 DEFINITION bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015110 VERSION NP_015110.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184028.1 REFERENCE 1 (residues 1 to 540) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 540) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 540) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 540) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 540) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11222. Method: conceptual translation. FEATURES Location/Qualifiers source 1..540 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..540 /product="bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase" /EC_number="2.5.1.3" /EC_number="2.7.1.50" /calculated_mol_wt="57928" Region 11..225 /region_name="thiE" /note="thiamine-phosphate diphosphorylase; TIGR00693" /db_xref="CDD:273222" Site order(13,15,43,45,90,114,134,136,143,145,177,181,207..210) /site_type="other" /note="thiamine phosphate binding site [chemical binding]" /db_xref="CDD:238317" Site order(43,45,47,75..76,95,114,143,145..146,181,209..210) /site_type="active" /db_xref="CDD:238317" Site order(45,47,75..76,92,95,114,146) /site_type="other" /note="pyrophosphate binding site [ion binding]" /db_xref="CDD:238317" Region 255..529 /region_name="thiM" /note="hydroxyethylthiazole kinase; TIGR00694" /db_xref="CDD:188074" Site order(270,272,278,282,288,290,311,313..314) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238575" Site order(271..276,278..279,282,290..293,295..296,299..300, 313..316,347..348,458..461,510..511,513..515,517..518,521) /site_type="other" /note="multimerization interface [polypeptide binding]" /db_xref="CDD:238575" Site order(338,365,367,370,415,417,419,457,463,465) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238575" CDS 1..540 /gene="THI6" /locus_tag="YPL214C" /coded_by="NM_001184028.1:1..1623" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16850348]" /experiment="EXISTENCE:mutant phenotype:GO:0004417 hydroxyethylthiazole kinase activity [PMID:7982968]" /experiment="EXISTENCE:mutant phenotype:GO:0004789 thiamine-phosphate diphosphorylase activity [PMID:7982968]" /experiment="EXISTENCE:mutant phenotype:GO:0009228 thiamine biosynthetic process [PMID:7982968]" /note="Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern" /db_xref="GeneID:855887" /db_xref="SGD:S000006135" ORIGIN 1 mvftkeevdy slylvtdstm lppgttlcsq veaglkngvt lvqirekdie tknfvaeale 61 vqkickkynv pliindridv amaidadgvh vgqddmpipm vrkllgpski lgwsvgkpse 121 vetlakwgpd mvdyigvgtl fptstkknpk kspmgpqgai aildaleefk atwcrtvgig 181 glhpdniqrv lcqcvasngk rsldgislvs dimaapdaca atkrlrglld atryqfvece 241 lnntfpttts iqnvisqvsn nrplvqhitn kvhqnfganv tlalgsspim seiesevsel 301 aripnaslll ntgsvapiem lkaainayne vnrpitfdpv gysatetrlc lnntlltygq 361 facikgncse ilslaklnnh kmkgvdsssg ktnidtlvra tqivafqyrt vavctgefdc 421 vadgtfggey klssgtegit aedlpcviie dgpipimgdi tasgcslgst iasfigglds 481 tgklfdavvg avllyksagk lastrcqgsg sfhvelidal yqlfhenkpe kwsaslkkfk // LOCUS NP_015111 238 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit LEA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015111 VERSION NP_015111.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184027.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11223. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..238 /product="U2 snRNP complex subunit LEA1" /calculated_mol_wt="27062" Region 54..75 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region <57..179 /region_name="LRR_9" /note="Leucine-rich repeat; pfam14580" /db_xref="CDD:405295" Region 76..97 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 98..116 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" Region 117..150 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275378" CDS 1..238 /gene="LEA1" /locus_tag="YPL213W" /coded_by="NM_001184027.1:1..717" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:9799242]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0071004 U2-type prespliceosome [PMID:16618970]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9799242]" /experiment="EXISTENCE:physical interaction:GO:0005686 U2 snRNP [PMID:9799242]" /note="Component of U2 snRNP complex; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein" /db_xref="GeneID:855888" /db_xref="SGD:S000006134" ORIGIN 1 mkftpsivid apqyyvdhfn gkynvdkcvi lrdlqletds esmpsslkhl tkpthildlt 61 nndlimipdl srrddihtll lgrnnivevd grllpmnvqn ltlsnnsirr fedlqrlrra 121 prtlknltli gnqvchlany rehvlrlvph letldfqnvt aeerksamsf prqadgdtlg 181 pvntairdng srdktmeimn lvvskmtver rnelkkqlae atsleeiarl ekllsggv // LOCUS NP_015112 544 aa linear PLN 30-JUN-2025 DEFINITION pseudouridine synthase PUS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015112 VERSION NP_015112.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184026.1 REFERENCE 1 (residues 1 to 544) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 544) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 544) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 544) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 544) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11224. Method: conceptual translation. FEATURES Location/Qualifiers source 1..544 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..544 /product="pseudouridine synthase PUS1" /calculated_mol_wt="62012" Region 79..407 /region_name="PseudoU_synth_PUS1_PUS2" /note="Pseudouridine synthase, PUS1/ PUS2 like; cd02568" /db_xref="CDD:211335" Site order(131..134,362) /site_type="active" /note="probable active site [active]" /db_xref="CDD:211335" CDS 1..544 /gene="PUS1" /locus_tag="YPL212C" /coded_by="NM_001184026.1:1..1635" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8641292]" /experiment="EXISTENCE:direct assay:GO:0009982 pseudouridine synthase activity [PMID:10356324]" /experiment="EXISTENCE:direct assay:GO:0031119 tRNA pseudouridine synthesis [PMID:10356324]" /experiment="EXISTENCE:mutant phenotype:GO:0031120 snRNA pseudouridine synthesis [PMID:10022901]" /experiment="EXISTENCE:mutant phenotype:GO:1990481 mRNA pseudouridine synthesis [PMID:25219674|PMID:25192136]" /note="tRNA:pseudouridine synthase; introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; also acts on U2 snRNA; also pseudouridylates some mRNAs, and pseudouridylation level varies with growth phase; nuclear protein that appears to be involved in tRNA export; PUS1 has a paralog, PUS2, that arose from the whole genome duplication" /db_xref="GeneID:855889" /db_xref="SGD:S000006133" ORIGIN 1 mseenlrpay ddqvnedvyk rgaqskltka rkadfddekd kkkdndkhid krpksgprld 61 engnplpkep rlpkrkvavm vgycgtgyhg mqynppnpti esalfkafve agaiskdnsn 121 dlkkngfmra artdkgvhag gnlislkmii edpdikqkin eklpegirvw diervnkafd 181 crkmcssrwy eyllptysli gpkpgsilyr dieesktelp gvldedlesk efweefkkda 241 nekfsteeie ailayvppar defdineely qkvkkykqle nahrrryris aaklakfras 301 tsqylgahnf hnftlgkdfk epsairfmkd ikvsdpfvig daqtewisik ihgqsfmlhq 361 irkmvsmatl itrcgcpver isqaygqqki nipkapalgl lleapvfegy nkrleqfgyk 421 aidfskyqde vdkfkmkhiy dkiykeevde nvfnaffsyi dsfnkvtgaq geetadksgp 481 avqksifefl takgipgltd apesnkkikq rkrmeeeeaa skkaeisstt qsnepevqpe 541 aaan // LOCUS NP_015113 181 aa linear PLN 30-JUN-2025 DEFINITION ribosome biosynthesis protein NIP7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015113 VERSION NP_015113.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184025.1 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11225. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..181 /product="ribosome biosynthesis protein NIP7" /calculated_mol_wt="20250" Region 2..86 /region_name="Nip7_N_euk" /note="N-terminal domain of eukaryotic 60S ribosome subunit biogenesis protein Nip7 and similar proteins; cd21146" /db_xref="CDD:409283" Site order(18..19,83..84,86) /site_type="other" /note="PUA domain interface [polypeptide binding]" /db_xref="CDD:409283" Region 95..172 /region_name="PUA_Nip7-like" /note="PUA RNA binding domain of ribosome assembly factor Nip7 and similar proteins; cd21151" /db_xref="CDD:409293" Site order(100,106,108..110,112..114,163..166) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:409293" CDS 1..181 /gene="NIP7" /locus_tag="YPL211W" /coded_by="NM_001184025.1:1..546" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9271378|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9271378]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:17443350|PMID:11583614|PMID:23212245]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:9271378]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:9271378]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]" /note="Nucleolar protein required for 60S ribosome subunit biogenesis; constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p" /db_xref="GeneID:855890" /db_xref="SGD:S000006132" ORIGIN 1 mrqlteeetk vvfeklagyi grnisflvdn kelphvfrlq kdrvyyvpdh vaklatsvar 61 pnlmslgicl gkftktgkfr lhitsltvla khakykiwik pngempflyg nhvlkahvgk 121 msddipehag vivfamndvp lgfgvsakst sesrnmqptg ivafrqadig eylrdedtlf 181 t // LOCUS NP_015114 640 aa linear PLN 30-JUN-2025 DEFINITION signal recognition particle subunit SRP72 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015114 VERSION NP_015114.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184024.1 REFERENCE 1 (residues 1 to 640) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 640) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 640) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 640) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 640) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11226. On Oct 2, 2003 this sequence version replaced NP_015114.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..640 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..640 /product="signal recognition particle subunit SRP72" /calculated_mol_wt="73410" Region 52..>256 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region <574..591 /region_name="SRP72" /note="SRP72 RNA-binding domain; pfam08492" /db_xref="CDD:462494" CDS 1..640 /gene="SRP72" /locus_tag="YPL210C" /coded_by="NM_001184024.1:1..1923" /experiment="EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]" /experiment="EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]" /note="Core component of the signal recognition particle (SRP); the SRP is a ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane" /db_xref="GeneID:855891" /db_xref="SGD:S000006131" ORIGIN 1 makdnltnll sqlniqlsqd ehsqveqtcv klldsgcenp advfrrclva viqqdkyqka 61 lhylkkfkhi ddkygrkfal eklyifykln mpdefntlyt aiitddldtv lkkdieslrg 121 ilhvraqycy knglyqeafk iyqhlashne kdqdsqiels cnervplsva telmnrsplv 181 tpmdessydl lfnesfimas vgkydkaiel lekalqgatn egyqndinti klqlsfvlqm 241 vgktaqskei lkgllqelka dspfslicqn nlnafvdfsk yntnfnlllr elnveklntf 301 nlqtftheqw sniqrnvlfl rlfnnvkihs qesllsrtfd kysklvdnvt lesyktqakk 361 lyhhttktil sgtdgstigi llltiqllii ekewenairi gelflneswk ssfekfndsq 421 aivcyilfel ykikgrnnsk svllkklgsv rvqlsgkiqe nipfwkhvgf ellsmgnake 481 skallreisn fskgdadvlv drvvssdsld iaqgidlvrd ididkliqlg vkplessakr 541 skntavskvq krkvlelkkk rkikrlekfl qgrdtsklpd perwlplrdr styrpkkkqq 601 gakqtqggam nkkseqaldi skkgkptvnk kpknkkkgrk // LOCUS NP_015115 367 aa linear PLN 30-JUN-2025 DEFINITION aurora kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015115 VERSION NP_015115.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184023.1 REFERENCE 1 (residues 1 to 367) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 367) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 367) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 367) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 367) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11227. Method: conceptual translation. FEATURES Location/Qualifiers source 1..367 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..367 /product="aurora kinase" /EC_number="2.7.11.1" /calculated_mol_wt="42815" Region 118..356 /region_name="STKc_Aurora" /note="Catalytic domain of the Serine/Threonine kinase, Aurora kinase; cd14007" /db_xref="CDD:270909" Site order(118,131,133,165,181..184,188,190,227,229,231..232, 234,245,248,263..266) /site_type="active" /db_xref="CDD:270909" Site order(188,190,227,229,231,248,263..266) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270909" Site order(244..252,254,257..266) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270909" CDS 1..367 /gene="IPL1" /locus_tag="YPL209C" /gene_synonym="PAC15" /coded_by="NM_001184023.1:1..1104" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11511347|PMID:12566427]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:11799062|PMID:10072382|PMID:16319894|PMID:16143104|P MID:23142046|PMID:25387524]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:12566427]" /experiment="EXISTENCE:direct assay:GO:0005828 kinetochore microtubule [PMID:11724818]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005876 spindle microtubule [PMID:11511347|PMID:11724818]" /experiment="EXISTENCE:direct assay:GO:0032133 chromosome passenger complex [PMID:19158380]" /experiment="EXISTENCE:direct assay:GO:0051233 spindle midzone [PMID:12566427]" /experiment="EXISTENCE:genetic interaction:GO:0044774 mitotic DNA integrity checkpoint signaling [PMID:16651657]" /experiment="EXISTENCE:genetic interaction:GO:0044779 meiotic spindle checkpoint signaling [PMID:37018287]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:8293973]" /experiment="EXISTENCE:mutant phenotype:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:10072382]" /experiment="EXISTENCE:mutant phenotype:GO:0032465 regulation of cytokinesis [PMID:16615892]" /experiment="EXISTENCE:mutant phenotype:GO:0045143 homologous chromosome segregation [PMID:17289568]" /experiment="EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:17289568|PMID:17371833]" /experiment="EXISTENCE:mutant phenotype:GO:0051228 mitotic spindle disassembly [PMID:12566427]" /experiment="EXISTENCE:mutant phenotype:GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint [PMID:16327780]" /experiment="EXISTENCE:mutant phenotype:GO:1901673 regulation of mitotic spindle assembly [PMID:24386320]" /experiment="EXISTENCE:mutant phenotype:GO:1901925 negative regulation of protein import into nucleus during spindle assembly checkpoint [PMID:23177738]" /note="Aurora kinase of the chromosomal passenger complex; mediates release of mono-oriented kinetochores from microtubules in MI, and kinetochore release from SPB clusters during meiotic exit; maintains meiotic spindle checkpoint delay in a mek1 null; maintains condensed chromosomes in anaphase; required for SPB cohesion and preventing multipolar spindle formation; promotes telomerase release at G2/M; Iocalizes to nuclear foci that diffuse upon DNA replication stress; inhibits Pse1p upon SAC arrest" /db_xref="GeneID:855892" /db_xref="SGD:S000006130" ORIGIN 1 mqrnslvnik lnanspskkt ttrpntsrin kpwrishspq qrnpnskips pvreklnrlp 61 vnnkkfldme sskipspirk atsskmihen kklpkfksls lddfelgkkl gkgkfgkvyc 121 vrhrstgyic alkvmekeei ikynlqkqfr reveiqtsln hpnltksygy fhdekrvyll 181 meylvngemy kllrlhgpfn dilasdyiyq ianaldymhk kniihrdikp eniligfnnv 241 ikltdfgwsi inppenrrkt vcgtidylsp emvesreydh tidawalgvl afelltgapp 301 feeemkdtty kriaaldikm psnisqdaqd lilkllkydp kdrmrlgdvk mhpwilrnkp 361 fwenkrl // LOCUS NP_015116 583 aa linear PLN 30-JUN-2025 DEFINITION protein-lysine N-methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015116 VERSION NP_015116.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184022.1 REFERENCE 1 (residues 1 to 583) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 583) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 583) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 583) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 583) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11228. Method: conceptual translation. FEATURES Location/Qualifiers source 1..583 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..583 /product="protein-lysine N-methyltransferase" /calculated_mol_wt="67048" Region 10..288 /region_name="SET" /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; cl40432" /db_xref="CDD:394802" Site order(33..34,235..240,249..251,271..274) /site_type="active" /db_xref="CDD:380914" Site order(33..34,236..240,273) /site_type="other" /note="SAM binding site [polypeptide binding]" /db_xref="CDD:380914" CDS 1..583 /gene="RKM1" /locus_tag="YPL208W" /coded_by="NM_001184022.1:1..1752" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016279 protein-lysine N-methyltransferase activity [PMID:16096273]" /experiment="EXISTENCE:direct assay:GO:0018027 peptidyl-lysine dimethylation [PMID:16096273]" /experiment="EXISTENCE:mutant phenotype:GO:0016279 protein-lysine N-methyltransferase activity [PMID:16096273]" /experiment="EXISTENCE:mutant phenotype:GO:0018026 peptidyl-lysine monomethylation [PMID:22522802]" /experiment="EXISTENCE:mutant phenotype:GO:0018027 peptidyl-lysine dimethylation [PMID:16096273]" /note="SET-domain lysine-N-methyltransferase; catalyzes the formation of dimethyllysine residues on the large ribosomal subunit proteins L23 (Rpl23Ap and Rpl23Bp) and monomethyllysine residues on L18 (Rps18Ap and Rps18Bp)" /db_xref="GeneID:855893" /db_xref="SGD:S000006129" ORIGIN 1 mssdalkall qwgasfgviv peelkflytd lkgiicvcek didnpsikip peivisrnlp 61 mkffglsest kningwlklf fakikfdrdn dtivdnvrvn dkfkpyldal psrlnsplvw 121 npselkrlss tnignsihek fegifkewfe lvsssdmfdl ervaddvqtf hnldeltyea 181 lyekilkite lqrptiwysf paflwshlif israfpeyvl nrncpdnsiv llpivdllnh 241 dyrskvkwyp engwfcyeki gtasqsrels nnyggkgnee llsgygfvle dnifdsvalk 301 vklpldvvst iletepslkl pllsdyttya fenkdcvqqe kkatrsatdy ingvtyfini 361 qneqclepll dlftylskae eedlhdlrar lqgiqmlrna lqsklnsitg ppatddsyai 421 dpyrvycadv ytkgqkqilk ealtrlkkle ktmlsenkhq lltmskilkn dpafaetelp 481 slfsnedgee vifestydll ilwillktkk nsyptkyewv gqqytnfkqt ayisddakaf 541 htayfekqdd vdlaevdhai qfvvdnsftr tsstteetil vrk // LOCUS NP_015117 810 aa linear PLN 30-JUN-2025 DEFINITION putative tRNA 4-demethylwyosine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015117 VERSION NP_015117.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184021.1 REFERENCE 1 (residues 1 to 810) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 810) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 810) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 810) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 810) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11229. Method: conceptual translation. FEATURES Location/Qualifiers source 1..810 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..810 /product="putative tRNA 4-demethylwyosine synthase" /EC_number="4.1.3.44" /calculated_mol_wt="89675" Region 144..>184 /region_name="RnpA" /note="RNase P protein component [Translation, ribosomal structure and biogenesis]; COG0594" /db_xref="CDD:440359" Region 207..354 /region_name="Flavodoxin_1" /note="pfam00258" /db_xref="CDD:425562" Region 424..727 /region_name="rSAM_TYW1" /note="wyosine biosynthesis protein TYW1; TIGR03972" /db_xref="CDD:274890" CDS 1..810 /gene="TYW1" /locus_tag="YPL207W" /coded_by="NM_001184021.1:1..2433" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031591 wybutosine biosynthetic process [PMID:34184886]" /experiment="EXISTENCE:direct assay:GO:1904047 S-adenosyl-L-methionine binding [PMID:34184886]" /experiment="EXISTENCE:mutant phenotype:GO:0031591 wybutosine biosynthetic process [PMID:17150819|PMID:16642040|PMID:16162496]" /note="Iron-sulfur protein required for synthesis of wybutosine modified tRNA; wybutosine is a modified guanosine found at 3'-position adjacent to anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron" /db_xref="GeneID:855894" /db_xref="SGD:S000006128" ORIGIN 1 mdgfrvagal vvgaltaayl yfggrfsial viivgygiyc neasggsqds qekldlnkqq 61 kkpccsdkki adggkktggc csdkkngggk gggccsskgg kkggccsskg gkkggccssk 121 knigdnenta tevekavnyp vtvdftevfr kptkkrsstp kvfsknsssn srvgkklsvs 181 kkigpdglik saltisnetl lssqiyvlys slqgaaskaa ksvydklkel deltnepkll 241 nlddlsdfdd yfinvpvena lyvlvlpsyd idcpldyflq tleenandfr vdsfplrklv 301 gytvlglgds eswpekfcyq akradhwisr lggrrifplg kvcmktggsa kidewtslla 361 etlkddepii yeydenadse edeeegngsd elgdvedigg kgsngkfsga deikqmvakd 421 sptyknltkq gykvigshsg vkicrwtkne lrgkgscykk slfniassrc meltpslacs 481 skcvfcwrhg tnpvsknwrw evdepeyile nalkghysmi kqmrgvpgvi aerfakafev 541 rhcalslvge pilyphinkf iqllhqkgit sflvcnaqhp ealrnivkvt qlyvsidapt 601 ktelkkvdrp lykdfwermv ecleilktvq nhqrtvfrlt lvkgfnmgdv sayadlvqrg 661 lpgfievkga tfsgssdgng npltmqnipf yeecvkfvka fttelqrrgl hydlaaehah 721 snclliadtk fkingewhth idfdkffvll nsgkdftymd ylektpewal fgnggfapgn 781 trvyrkdkkk qnkenqettt retplppipa // LOCUS NP_015118 321 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylglycerol phospholipase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015118 VERSION NP_015118.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184020.1 REFERENCE 1 (residues 1 to 321) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 321) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 321) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 321) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 321) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11230. Method: conceptual translation. FEATURES Location/Qualifiers source 1..321 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..321 /product="phosphatidylglycerol phospholipase" /calculated_mol_wt="36939" Region 4..244 /region_name="GDPD_YPL206cp_fungi" /note="Glycerophosphodiester phosphodiesterase domain of Saccharomyces cerevisiae YPL206cp and similar proteins; cd08570" /db_xref="CDD:176512" Site order(7,34,36,49,105,139,220) /site_type="active" /note="putative active site [active]" /db_xref="CDD:176512" Site order(7,49) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:176512" Site order(34,36,105) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:176512" CDS 1..321 /gene="PGC1" /locus_tag="YPL206C" /coded_by="NM_001184020.1:1..966" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:18434318|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:12514182|PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0034479 phosphatidylglycerol phospholipase C activity [PMID:18434318]" /experiment="EXISTENCE:mutant phenotype:GO:0034478 phosphatidylglycerol catabolic process [PMID:18434318]" /experiment="EXISTENCE:mutant phenotype:GO:0034479 phosphatidylglycerol phospholipase C activity [PMID:18434318]" /experiment="EXISTENCE:mutant phenotype:GO:0046475 glycerophospholipid catabolic process [PMID:16172116]" /note="Phosphatidylglycerol phospholipase C; regulates phosphatidylglycerol (PG) accumulation via a phospholipase C-type degradation mechanism; PG levels affect mitochondrial function; contains glycerophosphodiester phosphodiesterase motifs" /db_xref="GeneID:855895" /db_xref="SGD:S000006127" ORIGIN 1 mveivghraf karypentll afekayaaga dvietdlqmt sdgmvvvnhd sdtgrmwdkn 61 lvigestwee vkrlrckedg slammtlkei ltwavchpga klmldikftn ekiimiktfv 121 imlevkndlk fwqeritwgl wlldwydfgi etgvlkdfkv ivislsldia sqfvkrsltl 181 ndphyklfgi svhfvsswts qfrlrllpvl mkndikvylw tvnkpidfky lcelpihgai 241 tddpikarkl cdghtvakkp taekkfvaps lasvdglrfh afikvynilc tllyskwvhi 301 klcgwsiayv iflflrtihf l // LOCUS NP_015120 494 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase HRR25 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015120 VERSION NP_015120.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184018.1 REFERENCE 1 (residues 1 to 494) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 494) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 494) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 494) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 494) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11231. Method: conceptual translation. FEATURES Location/Qualifiers source 1..494 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..494 /product="serine/threonine protein kinase HRR25" /EC_number="2.7.11.1" /calculated_mol_wt="57209" Region 8..282 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(15..18,21,23,36,38,66,82..85,128,132..133,135, 148..149) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..494 /gene="HRR25" /locus_tag="YPL204W" /gene_synonym="KTI14" /coded_by="NM_001184018.1:1..1485" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:16990132]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:29915153]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:1495994|PMID:21532587|PMID:25569479]" /experiment="EXISTENCE:direct assay:GO:0004713 protein tyrosine kinase activity [PMID:7803855]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8034689]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:21532587]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:17461799]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:8034689]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17461799|PMID:14597664]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762|PMID:14597664|PMID:17461799]" /experiment="EXISTENCE:direct assay:GO:0033551 monopolin complex [PMID:16990132]" /experiment="EXISTENCE:direct assay:GO:0042274 ribosomal small subunit biogenesis [PMID:25778921]" /experiment="EXISTENCE:direct assay:GO:0060628 regulation of ER to Golgi vesicle-mediated transport [PMID:21532587]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:25287303]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0004674 protein serine/threonine kinase activity [PMID:16990132]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:1887218]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:14597664]" /experiment="EXISTENCE:mutant phenotype:GO:0033551 monopolin complex [PMID:16990132]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:18256024]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:25778921|PMID:16738661]" /experiment="EXISTENCE:mutant phenotype:GO:0051455 spindle attachment to meiosis I kinetochore [PMID:16990132]" /experiment="EXISTENCE:mutant phenotype:GO:0060628 regulation of ER to Golgi vesicle-mediated transport [PMID:21532587]" /experiment="EXISTENCE:mutant phenotype:GO:0106214 regulation of vesicle fusion with Golgi apparatus [PMID:26195667]" /experiment="EXISTENCE:mutant phenotype:GO:2000370 positive regulation of clathrin-dependent endocytosis [PMID:25287303]" /experiment="EXISTENCE:mutant phenotype:GO:2000785 regulation of autophagosome assembly [PMID:26195667]" /experiment="EXISTENCE:mutant phenotype:GO:2001159 regulation of protein localization by the Cvt pathway [PMID:25287303|PMID:24968893]" /experiment="EXISTENCE:physical interaction:GO:0033551 monopolin complex [PMID:16990132]" /note="Conserved casein kinase, monopolin subunit; regulates diverse events including vesicular traffic, DNA repair, CVT pathway, cohesion cleavage, attachment of sister kinetochores at meiosis I, exit from meiosis II, and ribosomal subunit biogenesis; binds the RNAPII CTD; phosphorylates COPII coat subunits; interacts with Sit4p phosphatase; antagonizes calcineurin signaling, reducing nuclear accumulation of Crz1p; phosphorylates Dsn1p; homolog of mammalian CK1delta" /db_xref="GeneID:855897" /db_xref="SGD:S000006125" ORIGIN 1 mdlrvgrkfr igrkigsgsf gdiyhgtnli sgeevaikle sirsrhpqld yesrvyryls 61 ggvgipfirw fgregeynam vidllgpsle dlfnychrrf sfktvimlal qmfcriqyih 121 grsfihrdik pdnflmgvgr rgstvhvidf glskkyrdfn thrhipyren ksltgtarya 181 svnthlgieq srrddleslg yvliyfckgs lpwqglkatt kkqkydrime kklnvsvetl 241 csglplefqe ymaycknlkf dekpdylfla rlfkdlsikl eyhndhlfdw tmlrytkamv 301 ekqrdlliek gdlnansnaa sasnstdnks etfnkiklla mkkfpthfhy yknedkhnps 361 peeikqqtil nnnaasslpe ellnaldkgm enlrqqqpqq qvqssqpqpq pqqlqqqpng 421 qrpnyypepl lqqqqrdsqe qqqqvpmatt ratqyppqin snnfntnqas vppqmrsnpq 481 qppqdkpagq siwl // LOCUS NP_015121 380 aa linear PLN 30-JUN-2025 DEFINITION cAMP-dependent protein kinase catalytic subunit TPK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015121 VERSION NP_015121.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184017.1 REFERENCE 1 (residues 1 to 380) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 380) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 380) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 380) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 380) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11232. Method: conceptual translation. FEATURES Location/Qualifiers source 1..380 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..380 /product="cAMP-dependent protein kinase catalytic subunit TPK2" /EC_number="2.7.11.11" /calculated_mol_wt="44089" Region 69..358 /region_name="STKc_PKA_like" /note="Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; cd05580" /db_xref="CDD:270732" Site order(76..82,84,97,99,131,147..150,154,193,195,197..198, 200,210..211,355) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270732" Site order(77..82,84,97,99,109,131,147..148,150,154,156,160,193, 195..198,200,210..211,214,225,227..230,257,261..263, 266..268,270,273,355,358) /site_type="active" /db_xref="CDD:270732" Site order(78,80..81,109..111,154,156,160,193,195..197,214, 225..230,257,261..263,266..268,270,273..274,358) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270732" Site order(80,110..111,113..114,154,156,160,195..197,214, 223..228,231,238..239,257,270..271,274..275,278,358) /site_type="other" /note="regulatory subunit interface [polypeptide binding]" /db_xref="CDD:270732" Site order(210..218,222..230) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270732" CDS 1..380 /gene="TPK2" /locus_tag="YPL203W" /gene_synonym="PKA2; PKA3; YKR1" /coded_by="NM_001184017.1:1..1143" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:26403272]" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:22899713]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004691 cAMP-dependent protein kinase activity [PMID:12024012]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18417610|PMID:22932476|PMID:12024012]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005952 cAMP-dependent protein kinase complex [PMID:12024012]" /experiment="EXISTENCE:genetic interaction:GO:0004691 cAMP-dependent protein kinase activity [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0005952 cAMP-dependent protein kinase complex [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0007265 Ras protein signal transduction [PMID:3036373]" /experiment="EXISTENCE:genetic interaction:GO:0010607 negative regulation of cytoplasmic mRNA processing body assembly [PMID:21925385]" /experiment="EXISTENCE:genetic interaction:GO:0010737 protein kinase A signaling [PMID:20133652]" /experiment="EXISTENCE:mutant phenotype:GO:0001403 invasive growth in response to glucose limitation [PMID:12150916]" /experiment="EXISTENCE:mutant phenotype:GO:0070314 G1 to G0 transition [PMID:22899713]" /experiment="EXISTENCE:mutant phenotype:GO:0071333 cellular response to glucose stimulus [PMID:36167807]" /experiment="EXISTENCE:mutant phenotype:GO:2000766 negative regulation of cytoplasmic translation [PMID:22899713]" /experiment="EXISTENCE:physical interaction:GO:0005952 cAMP-dependent protein kinase complex [PMID:12024012]" /note="cAMP-dependent protein kinase catalytic subunit; promotes nutrient responsive growth via the Ras-cAMP signaling pathway; phosphorylates and inhibits histone demethylase Jhd2p in response to glucose, promoting H3K4 trimethylation and maintaining H3K14 acetylation by preventing chromatin binding of Rpd3p; required for Sfl1p-mediated pseudohyphal growth; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:855898" /db_xref="SGD:S000006124" ORIGIN 1 mefvaeraqp vgqtiqqqnv ntygqgvlqp hhdlqqrqqq qqqrqhqqll tsqlpqkslv 61 skgkytlhdf qimrtlgtgs fgrvhlvrsv hngryyaikv lkkqqvvkmk qvehtnderr 121 mlklvehpfl irmwgtfqda rnifmvmdyi eggelfsllr ksqrfpnpva kfyaaevila 181 leylhahnii yrdlkpenil ldrnghikit dfgfakevqt vtwtlcgtpd yiapevittk 241 pynksvdwws lgvliyemla gytpfydttp mktyekilqg kvvyppyfhp dvvdllskli 301 tadltrrign lqsgsrdika hpwfsevvwe rllakdietp yeppitsgig dtslfdqype 361 eqldygiqgd dpyaeyfqdf // LOCUS NP_015122 416 aa linear PLN 30-JUN-2025 DEFINITION Aft2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015122 VERSION NP_015122.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184016.1 REFERENCE 1 (residues 1 to 416) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 416) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 416) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 416) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 416) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11233. Method: conceptual translation. FEATURES Location/Qualifiers source 1..416 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..416 /product="Aft2p" /calculated_mol_wt="46974" Region 51..137 /region_name="AFT" /note="Transcription factor AFT; pfam08731" /db_xref="CDD:400877" CDS 1..416 /gene="AFT2" /locus_tag="YPL202C" /coded_by="NM_001184016.1:1..1251" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:16024809]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:27402848]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11448968]" /experiment="EXISTENCE:genetic interaction:GO:0006879 intracellular iron ion homeostasis [PMID:16024809]" /experiment="EXISTENCE:genetic interaction:GO:0010106 cellular response to iron ion starvation [PMID:16024809]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16024809]" /experiment="EXISTENCE:mutant phenotype:GO:0032048 cardiolipin metabolic process [PMID:27402848]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:27402848]" /experiment="EXISTENCE:mutant phenotype:GO:0051536 iron-sulfur cluster binding [PMID:31493153]" /experiment="EXISTENCE:mutant phenotype:GO:2000185 regulation of phosphate transmembrane transport [PMID:27618952]" /note="Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication" /db_xref="GeneID:855899" /db_xref="SGD:S000006123" ORIGIN 1 mkaksmksii svpisvsktg kmkltaspdn lasmmskdqn klihldpvps fedrheikpw 61 lqkifypqgi diviersdss kvtfkcrsvr skvglnpksk gsssrshacp friraaysvr 121 lqkwnvvvmn nihshelrfd litktddykk fkenlrqknd ekaiktfdel eykaslnlpl 181 vtpiiscdcg ltkeieafnn iflplsnppl tskknllktn knsvskiksr qmdnskprpr 241 lktkldadlh dtgfldnfkt rnscvkieke dsltnlneid ftnmfcndnf iqnynqglme 301 llteptpgps ssscilpstp trplsqskmd ialsesttss pnfmetdapy gdeiikvskd 361 tksnaptadt diatnlgker nenfgmlnyn yeallhfnde hfnelnsidp alisky // LOCUS NP_015123 461 aa linear PLN 30-JUN-2025 DEFINITION Yig1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015123 VERSION NP_015123.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184015.1 REFERENCE 1 (residues 1 to 461) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 461) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 461) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 461) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 461) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11234. Method: conceptual translation. FEATURES Location/Qualifiers source 1..461 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..461 /product="Yig1p" /calculated_mol_wt="52743" CDS 1..461 /gene="YIG1" /locus_tag="YPL201C" /coded_by="NM_001184015.1:1..1386" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16358322]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16358322]" /experiment="EXISTENCE:mutant phenotype:GO:0006114 glycerol biosynthetic process [PMID:16358322]" /note="Protein that interacts with glycerol 3-phosphatase; plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol" /db_xref="GeneID:855900" /db_xref="SGD:S000006122" ORIGIN 1 mgipmqiyqd gkgvqfyhtr yqnvfderas kygnytvnnd ypqlpdtike hidqltfsnv 61 gedggdvgny seedddgdee keledvfrsn rglefvrinn yftthdlqsf ksfrnfnsky 121 wifysnqaed kklllydfng qhlifikqqf ygqlnlllsd aiicmdcnfg ynsntiqilv 181 gfqngkllkl ncdlngnvnn hlllkdpsts shqshlsiln vwagllphfv vsfslkdgll 241 itsldhqqsn gsfqsfhtni dlpvdlrttt nvksvlnfpq ftlykgndmi fhcknllgsd 301 astlnkeinf mlkidedvqk idyllktnhi lletnmryls iptrdpiens nssppvsdse 361 vypifyktqe lhvhasgtgr qianngkyif iteqhlygta lsvykysisf krwlfvgysd 421 irakygirsv kdlfvgncps vnspvltilt ddnniqtill k // LOCUS NP_015124 156 aa linear PLN 30-JUN-2025 DEFINITION Csm4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015124 VERSION NP_015124.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184014.1 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11235. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..156 /product="Csm4p" /calculated_mol_wt="18176" CDS 1..156 /gene="CSM4" /locus_tag="YPL200W" /coded_by="NM_001184014.1:1..471" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:18585352]" /experiment="EXISTENCE:direct assay:GO:0005640 nuclear outer membrane [PMID:32059771]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12514182]" /experiment="EXISTENCE:genetic interaction:GO:0045141 meiotic telomere clustering [PMID:18585352]" /experiment="EXISTENCE:mutant phenotype:GO:0007129 homologous chromosome pairing at meiosis [PMID:21339478]" /experiment="EXISTENCE:mutant phenotype:GO:0010520 regulation of reciprocal meiotic recombination [PMID:18818742|PMID:18818741]" /experiment="EXISTENCE:mutant phenotype:GO:0034993 meiotic nuclear membrane microtubule tethering complex [PMID:32059771]" /experiment="EXISTENCE:mutant phenotype:GO:0045132 meiotic chromosome segregation [PMID:11470404]" /experiment="EXISTENCE:mutant phenotype:GO:0045141 meiotic telomere clustering [PMID:18818742|PMID:18585352]" /experiment="EXISTENCE:mutant phenotype:GO:0140444 cytoskeleton-nuclear membrane anchor activity [PMID:32059771]" /note="Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog, MPS2, that arose from the whole genome duplication" /db_xref="GeneID:855901" /db_xref="SGD:S000006121" ORIGIN 1 mmdgsitrkv tstlsnqlat wkwklqlsll erklatinnd yfllqwellf itnevmkwke 61 miaflesqlf cttqnfvaqe thdretfqsl vddynkqlse nnliisvlks rpqlssfpiy 121 lsdevcshlk fviaelnsli ivffislvfl wvsiev // LOCUS NP_015125 240 aa linear PLN 30-JUN-2025 DEFINITION Smr domain-containing protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_015125 VERSION NP_015125.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184013.1 REFERENCE 1 (residues 1 to 240) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 240) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 240) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 240) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11236. Method: conceptual translation. FEATURES Location/Qualifiers source 1..240 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..240 /product="Smr domain-containing protein" /calculated_mol_wt="26627" Region 28..89 /region_name="DUF1771" /note="Domain of unknown function (DUF1771); pfam08590" /db_xref="CDD:462528" Region 94..172 /region_name="SMR" /note="Small MutS-related domain; smart00463" /db_xref="CDD:214676" CDS 1..240 /locus_tag="YPL199C" /coded_by="NM_001184013.1:1..723" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:32234470]" /note="Protein involved in nonstop mRNA decay; predicted to be palmitoylated" /db_xref="GeneID:855902" /db_xref="SGD:S000006120" ORIGIN 1 mkgtggvvvg tqnpvrdynh stdeeyqrlr rladeaykkr dqlshesqta yqqgdkklah 61 elsekskaql ktaedfnmqa aeyvfvenna dsssneidlh glyvkealfi lqkrikfaid 121 hnepqlnviv gkglhsqngi aklkpsieef cakhgirnhl ekgnsgvlvl elqgvqmqmd 181 gpavnaptnq ynaqphpqyn nnggqpqgqa qnynnsgndn kdstltsifk ifcnciqsla // LOCUS NP_015126 244 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL30 RPL7B [Saccharomyces cerevisiae S288C]. ACCESSION NP_015126 VERSION NP_015126.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184012.1 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11237. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..244 /product="60S ribosomal protein uL30 RPL7B" /calculated_mol_wt="27565" Region 10..244 /region_name="uL30_euk" /note="60S ribosomal protein uL30, eukaryotic form; TIGR01310" /db_xref="CDD:273548" CDS 1..244 /gene="RPL7B" /locus_tag="YPL198W" /coded_by="NM_001184012.1:1..735" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:23874617]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:23874617]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:19466602]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:19466602]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:23874617]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:23945946]" /experiment="EXISTENCE:mutant phenotype:GO:0000470 maturation of LSU-rRNA [PMID:22893726]" /note="Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication" /db_xref="GeneID:855903" /db_xref="SGD:S000006119" ORIGIN 1 mstekiltpe sqlkktkaqq ktaeqiaaer aarkaankek raiilernaa yqkeyetaer 61 niiqakrdak aagsyyveaq hklvfvvrik ginkippkpr kvlqllrltr insgtfvkvt 121 katlellkli epyvaygyps ystirqlvyk rgfgkinkqr vplsdnaiie anlgkygils 181 iddliheiit vgphfkqann flwpfklsnp sggwgvprkf khfiqggsfg nreefinklv 241 kamn // LOCUS NP_015128 273 aa linear PLN 30-JUN-2025 DEFINITION Oxr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015128 VERSION NP_015128.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184010.1 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11238. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..273 /product="Oxr1p" /calculated_mol_wt="30648" Region 40..273 /region_name="OXR1" /note="Oxidation resistance protein [DNA replication, recombination, and repair]; COG5142" /db_xref="CDD:227471" CDS 1..273 /gene="OXR1" /locus_tag="YPL196W" /coded_by="NM_001184010.1:1..822" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:38565737]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:15060142]" /experiment="EXISTENCE:direct assay:GO:0010849 regulation of proton-transporting ATPase activity, rotational mechanism [PMID:34918374]" /experiment="EXISTENCE:direct assay:GO:0032984 protein-containing complex disassembly [PMID:34918374]" /experiment="EXISTENCE:mutant phenotype:GO:0010849 regulation of proton-transporting ATPase activity, rotational mechanism [PMID:38565737]" /experiment="EXISTENCE:mutant phenotype:GO:0032984 protein-containing complex disassembly [PMID:38565737]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:38589611]" /note="Protein that regulates the vacuolar V-ATPase; inhibits V1-ATPase activity and triggers ATP-dependent disassembly of the V-ATPase holoenzyme, counteracting the function of the RAVE complex; localizes to the cytoplasm; required for retention of the vacuolar-ATPase V0 domain subunit Stv1p in pre-vacuolar compartments; involved in resistance to oxidative damage; member of a conserved family of TLDc domain proteins found in eukaryotes; contains an N-terminal EF-hand-like domain" /db_xref="GeneID:855905" /db_xref="SGD:S000006117" ORIGIN 1 mfgvkdaifk ikrsiagtds sdstayttas esspqlkdsh npfrnkttse rtiveegslp 61 pvrlngylps tknklltpem cdeirtlmpt riqlytewnl lysleqhgss lhslysnvap 121 dskefrrvgy vlvikdrkng ifgaysneaf hpnehrqytg ngecflwkld kvpdvnisek 181 eeseqegkeg keegdkeerw rfsgypytgv nefaiyctse flsmgagdgh ygllcddgll 241 hgvsnpcqty gnevlskegk kfsivalevw rvg // LOCUS NP_015129 932 aa linear PLN 30-JUN-2025 DEFINITION Apl5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015129 VERSION NP_015129.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184009.1 REFERENCE 1 (residues 1 to 932) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 932) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 932) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 932) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 932) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 932) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 932) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11239. Method: conceptual translation. FEATURES Location/Qualifiers source 1..932 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..932 /product="Apl5p" /calculated_mol_wt="106794" Region 45..610 /region_name="Adaptin_N" /note="Adaptin N terminal region; pfam01602" /db_xref="CDD:396262" CDS 1..932 /gene="APL5" /locus_tag="YPL195W" /gene_synonym="YKS4" /coded_by="NM_001184009.1:1..2799" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:17895371]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:9335339]" /experiment="EXISTENCE:mutant phenotype:GO:0030123 AP-3 adaptor complex [PMID:9250663]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:10559961]" /note="Delta adaptin-like subunit of the clathrin associated protein complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; suppressor of loss of casein kinase 1 function; the clathrin associated protein complex is also known as AP-3" /db_xref="GeneID:855906" /db_xref="SGD:S000006116" ORIGIN 1 mtslyapgae dirqrlrpfg fffekslkdl ikgirshnet pekldqffkq vlsecreevn 61 spdlnsktna vlkltylemy gfdmawcnfh ilevmssnkl qqkrvgylaa sqsfykdsdi 121 lmlatnllkk dlkydgnndv vkvgialsgl stiitpslar diaddlftml nstrpyirkk 181 aitalfkvfl qypealrdnf dkfvsklddd disvvsaavs vicelskknp qpfiqlspll 241 yeilvtidnn wiiirllklf tnlsqvepkl rakllpkile lmestvatsv iyesvncivk 301 gnmleeddfe tamaclerlh tfcdsqdpnl ryiscilfyk igkintdfis rfdqliirll 361 sdvdvsirsk aielvegivd ednlkaivqt lmkqfvdedv vilqtgsivy ekskripiii 421 penykikmvn viisicsadn yssvndfewy navimdlaml cqdisdkslg skigeqfrnl 481 mikvpsmrev tianiiklis ndninkqlpt vlreciwclg efstlvengn dlikimteni 541 syyshsvqev lilalvkvfs nwcnnfqedk rfeikmvlke lieffenlsy sstfevqers 601 vevleflrls lealeedteg lpmllsevlp sffnayelap iargtqlkla vdenldletp 661 fltkeaadel ldeqksdais dlmsdismde qvelkfvdds dtsyeekekl ddfenpfeie 721 rekermsnpy ylgeedeert knskdlldln eeessdkkpe tirlnrtdns lnslslstte 781 isrkkkkgkk knrvqvlsde pvieaapkrk dafqkphdnh stqnplkkdk inlrmhsqle 841 nfdfsnfgqs snagrgsqee gnlrkedele lsrleanliv kdekdnlsdt eevivikkkk 901 kgkksksknk lktkaknspe pneflrdqst di // LOCUS NP_015130 612 aa linear PLN 30-JUN-2025 DEFINITION Ddc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015130 VERSION NP_015130.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184008.1 REFERENCE 1 (residues 1 to 612) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 612) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 612) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 612) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11240. Method: conceptual translation. FEATURES Location/Qualifiers source 1..612 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..612 /product="Ddc1p" /calculated_mol_wt="69563" CDS 1..612 /gene="DDC1" /locus_tag="YPL194W" /coded_by="NM_001184008.1:1..1839" /experiment="EXISTENCE:direct assay:GO:0000725 recombinational repair [PMID:16840526]" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:11825877]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030295 protein kinase activator activity [PMID:31340146]" /experiment="EXISTENCE:direct assay:GO:0030896 checkpoint clamp complex [PMID:9891048|PMID:12604797|PMID:9670034]" /experiment="EXISTENCE:genetic interaction:GO:0000725 recombinational repair [PMID:16840526]" /experiment="EXISTENCE:mutant phenotype:GO:0007095 mitotic G2 DNA damage checkpoint signaling [PMID:9311982]" /experiment="EXISTENCE:mutant phenotype:GO:0031571 mitotic G1 DNA damage checkpoint signaling [PMID:9311982]" /experiment="EXISTENCE:mutant phenotype:GO:0031573 mitotic intra-S DNA damage checkpoint signaling [PMID:9311982]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:11825877]" /experiment="EXISTENCE:mutant phenotype:GO:0051598 meiotic recombination checkpoint signaling [PMID:11825877]" /note="DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress" /db_xref="GeneID:855907" /db_xref="SGD:S000006115" ORIGIN 1 msfkatites gkqniwfrai yvlstiqddi kitvttneli awsmnetdtt lcqvrfqksf 61 feeyefkphe ivfgengvqv iedtygnshk lysfrvngrh lttisrkpdg dgiksftiav 121 nntstcpesl anrlivviem dslivkeycp qfqpikydpi iinlkykrrf ldvfgtaasd 181 rnpqepldpk lldvftnter eltsalfnee vesdirkrnq ltaadeinyi ccnstllknf 241 ldncnvnvtd evkleinvhr lsitaftkav ygknndllrn alsmsntist ldlehyclft 301 tiedekqdkr shskrrehmk siifklkdfk nfitigpswk ttqdgndnis lwfchpgdpi 361 lmqmqkpgvk lelvevtdsn inddilegkf iktaisgske eaglkdnkes cesplkskta 421 lkrenlphsv agtrnsplkv syltpdngst vaktyrnnta rklfveeqsq stnyeqdkrf 481 rqassvhmnm nreqsfdigt thevacprne snslkrsiad icnetedptq qstfakradt 541 tvtwgkalpa addevscsni drkgmlkkek lkhmqgllns qndtsnhkkq dnkemedglg 601 ltqvekprgi fd // LOCUS NP_015131 381 aa linear PLN 30-JUN-2025 DEFINITION Rsa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015131 VERSION NP_015131.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184007.1 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11241. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..381 /product="Rsa1p" /calculated_mol_wt="43867" Region 224..274 /region_name="NUFIP1" /note="Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1); pfam10453" /db_xref="CDD:463096" CDS 1..381 /gene="RSA1" /locus_tag="YPL193W" /coded_by="NM_001184007.1:1..1146" /experiment="EXISTENCE:direct assay:GO:0005654 nucleoplasm [PMID:10567587]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:10567587]" /experiment="EXISTENCE:mutant phenotype:GO:0000492 box C/D snoRNP assembly [PMID:25170085]" /note="Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly" /db_xref="GeneID:855908" /db_xref="SGD:S000006114" ORIGIN 1 mnynnfensk gdghsrlpkp tysgtlsdgy deskikrqkt dsafnaaysp hmypnspyye 61 gswntgytpq lhhvaphnqy fhpiqpstqy nytsppnyte nyippvhqni syapalnlqk 121 wpssycentq alkndkdyqt sisyedvaip tvkeiqliek nrgkdtfmne ispvpsskdq 181 asaepteipr kdpelansna eddhnnlgle dddrdeqles eglgkvvlvp gtsialitde 241 dvkkwreerk kmwllkisnn kqkhmqemgi kedelksqps ifkesrkekq fiqsiqnqvq 301 rgnpkidlnl kliqrefane nsqlldfire lgdvglleye lsqqekdvlf gssednnknh 361 ykpnyknrkp nlsranftrn k // LOCUS NP_015132 133 aa linear PLN 30-JUN-2025 DEFINITION pheromone-regulated protein PRM3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015132 VERSION NP_015132.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184006.1 REFERENCE 1 (residues 1 to 133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 133) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11242. Method: conceptual translation. FEATURES Location/Qualifiers source 1..133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..133 /product="pheromone-regulated protein PRM3" /calculated_mol_wt="14297" CDS 1..133 /gene="PRM3" /locus_tag="YPL192C" /coded_by="NM_001184006.1:1..402" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:12514182]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:19297527]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:12514182|PMID:19297527]" /experiment="EXISTENCE:mutant phenotype:GO:0005635 nuclear envelope [PMID:12514182]" /experiment="EXISTENCE:mutant phenotype:GO:0048288 nuclear membrane fusion involved in karyogamy [PMID:19297527]" /note="Protein required for nuclear envelope fusion during karyogamy; pheromone-regulated; peripheral protein of the nuclear membrane; interacts with Kar5p at the spindle pole body" /db_xref="GeneID:855909" /db_xref="SGD:S000006113" ORIGIN 1 mtamkednaa litlkknndq eklrvhkltd assnsadgfv inkaknggpl nkkslvnneq 61 hikkavspgr vrkhktttss tksrtkskkk daseskvqre nkgsfyqgai fgsflgaavt 121 tvlsnlavka lqn // LOCUS NP_015133 360 aa linear PLN 30-JUN-2025 DEFINITION ubiquitinyl hydrolase 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015133 VERSION NP_015133.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184005.1 REFERENCE 1 (residues 1 to 360) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 360) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 360) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 360) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11243. Method: conceptual translation. FEATURES Location/Qualifiers source 1..360 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..360 /product="ubiquitinyl hydrolase 1" /EC_number="3.4.19.12" /calculated_mol_wt="40901" Region 51..150 /region_name="MINDY_DUB" /note="MINDY deubiquitinase; pfam04424" /db_xref="CDD:461303" Region <213..>352 /region_name="cdk7" /note="CDK-activating kinase assembly factor MAT1; TIGR00570" /db_xref="CDD:129661" CDS 1..360 /gene="MIY2" /locus_tag="YPL191C" /gene_synonym="MIY1" /coded_by="NM_001184005.1:1..1083" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071108 protein K48-linked deubiquitination [PMID:27292798]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1990380 K48-linked deubiquitinase activity [PMID:27292798]" /experiment="EXISTENCE:mutant phenotype:GO:0071444 cellular response to pheromone [PMID:39798877]" /note="K48-specific deubiquitinating (DUB) enzyme; MINDY family endo-type deubiquitinase that preferentially cleaves long K48-linked polyubiquitin chains between moieties; diploid deletion strain exhibits high budding index; GFP-fusion protein localizes to the cytoplasm endoplasmic reticulum and cell periphery in high-throughput studies; YPL191C has a paralog, YGL082W, that arose from the whole genome duplication; ortholog of human MINDY2/FAM63B" /db_xref="GeneID:855910" /db_xref="SGD:S000006112" ORIGIN 1 mdlsfttksv kingqnhril lqnengpcal lalanilils pdhtrfsnel irlvnkgsqi 61 slkelievla dialqvtdkp stdisellsl lprlheglni npefngsfen tkemsifrlf 121 nvdvvhgwvi nsfinenide klshysyesa qriltqaadi ncgisqdens devlrdamhl 181 glflnesptq ltafgllrlr ekllhnkfsi lfrndhfstl fkyedrlytl vtdfgyknck 241 divwqsldsv dgscdaffag nfsaaevngq qlstdierdf gtgnllleei qqiendkela 301 kqlqeqeqer vtkfeakrki hshkknseih apvkkdkfkr rssllnakas ekeksecvvm // LOCUS NP_015134 802 aa linear PLN 30-JUN-2025 DEFINITION Nab3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015134 VERSION NP_015134.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184004.1 REFERENCE 1 (residues 1 to 802) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 802) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 802) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 802) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11244. Method: conceptual translation. FEATURES Location/Qualifiers source 1..802 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..802 /product="Nab3p" /calculated_mol_wt="90308" Region 331..401 /region_name="RRM_Nab3p" /note="RNA recognition motif (RRM) found in yeast nuclear polyadenylated RNA-binding protein 3 (Nab3p) and similar proteins; cd12342" /db_xref="CDD:240788" Site order(331,333,361,363,366,368,395,397..401) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:240788" CDS 1..802 /gene="NAB3" /locus_tag="YPL190C" /gene_synonym="HMD1" /coded_by="NM_001184004.1:1..2409" /experiment="EXISTENCE:direct assay:GO:0001068 transcription regulatory region RNA binding [PMID:21084293]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:20805243|PMID:31960028]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:7962083]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0030847 termination of RNA polymerase II transcription, exosome-dependent [PMID:16427013]" /experiment="EXISTENCE:direct assay:GO:0035649 Nrd1 complex [PMID:10655211]" /experiment="EXISTENCE:direct assay:GO:0071041 antisense RNA transcript catabolic process [PMID:27190003]" /experiment="EXISTENCE:mutant phenotype:GO:0031124 mRNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0031126 sno(s)RNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0034472 snRNA 3'-end processing [PMID:11565036]" /experiment="EXISTENCE:mutant phenotype:GO:0042780 tRNA 3'-end processing [PMID:21460797]" /experiment="EXISTENCE:mutant phenotype:GO:0071028 nuclear mRNA surveillance [PMID:21113025]" /experiment="EXISTENCE:mutant phenotype:GO:0071034 CUT catabolic process [PMID:16973436]" /experiment="EXISTENCE:mutant phenotype:GO:0071041 antisense RNA transcript catabolic process [PMID:22028667]" /note="RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with exosome to mediate 3'-end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing; Nrd1-Nab3 pathway appears to have a role in rapid suppression of some genes when cells are shifted to poor growth conditions, indicating role for Nrd1-Nab3 in regulating cellular response to nutrient availability" /db_xref="GeneID:855911" /db_xref="SGD:S000006111" ORIGIN 1 msdenhnsdv qdipspelsv dsnsnenelm nnssaddgie fdapeeerea ereeeneeqh 61 eledvndeee edkeekgeen gevinteeee eeehqqkggn ddddddneee eeeeeddddd 121 dddddddeee eeeeeeegnd nssvgsdsaa edgedeedkk dktkdkevel rretlekeqk 181 dvdeaikkit reendnthfp tnmenvnydl lqkqvkyimd snmlnlpqfq hlpqeekmsa 241 ilamlnsnsd talsvpphds tisttasasa tsgarsndqr kpplsdaqrr mrfpradlsk 301 piteeehdry aaylhgenki temhnippks rlfignlplk nvskedlfri fspyghimqi 361 niknafgfiq fdnpqsvrda iecesqemnf gkklilevss snarpqfdhg dhgtnssstf 421 issakrpfqt esgdmynddn gagykksrrh tvscnifvkr tadrtyaiev fnrfrdgtgl 481 etdmiflkpr melgklinda ayngvwgvvl vnkthnvdvq tfykgsqget kfdeyisisa 541 ddavaifnni knnrnnsrpt dyramshqqn iygapplpvp ngpavgpppq tnyyqgysmp 601 ppqqqqqqpy gnygmpppsh dqgygsqppi pmnqsygryq tsipppppqq qipqgygryq 661 agpppqppsq tpmdqqqlls aiqnlppnvv snllsmaqqq qqqphaqqql vgliqsmqgq 721 apqqqqqqlg gyssmnsssp ppmstnyngq nisakpsapp mshqppppqq qqqqqqqqqq 781 qqqqpagnnv qslldslakl qk // LOCUS NP_878179 68 aa linear PLN 30-JUN-2025 DEFINITION Coa2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_878179 VERSION NP_878179.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184537.1 REFERENCE 1 (residues 1 to 68) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 68) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 68) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 68) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11245. Method: conceptual translation. FEATURES Location/Qualifiers source 1..68 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..68 /product="Coa2p" /calculated_mol_wt="7402" Region 1..67 /region_name="COA2" /note="Cytochrome C oxidase assembly factor 2; pfam17051" /db_xref="CDD:293656" CDS 1..68 /gene="COA2" /locus_tag="YPL189C-A" /coded_by="NM_001184537.1:1..207" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:18541668]" /experiment="EXISTENCE:mutant phenotype:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:18541668]" /experiment="EXISTENCE:physical interaction:GO:0033617 mitochondrial cytochrome c oxidase assembly [PMID:18541668]" /note="Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p" /db_xref="GeneID:1466518" /db_xref="SGD:S000028527" ORIGIN 1 mravtrnkiv nnlyfstfli afasvaigsv lpcpahsvds dspavqqhkl qlaheqelkr 61 kdalskki // LOCUS NP_015135 609 aa linear PLN 30-JUN-2025 DEFINITION putative O-acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015135 VERSION NP_015135.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184003.1 REFERENCE 1 (residues 1 to 609) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 609) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 609) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 609) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 609) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11246. Method: conceptual translation. FEATURES Location/Qualifiers source 1..609 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..609 /product="putative O-acyltransferase" /calculated_mol_wt="71158" Region 202..558 /region_name="MBOAT" /note="membrane-bound O-acyltransferase family; pfam03062" /db_xref="CDD:427117" CDS 1..609 /gene="GUP2" /locus_tag="YPL189W" /coded_by="NM_001184003.1:1..1830" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0015793 glycerol transmembrane transport [PMID:10931309]" /experiment="EXISTENCE:genetic interaction:GO:0071475 cellular hyperosmotic salinity response [PMID:10931309]" /note="Probable membrane protein; possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; homolog of the mammalian Hedgehog pathway modulator HHAT; GUP2 has a paralog, GUP1, that arose from the whole genome duplication" /db_xref="GeneID:855912" /db_xref="SGD:S000006110" ORIGIN 1 msmlriwsci vhffsvqald srikpdiefk rrqrifinss keengssssa vtvtrnpvls 61 snspspplwn twefrlyyla ftvvvpfmik aalatssesn pnyykfsgll ahgwilgrkv 121 dnsdpqyrff rsnffllail illqiilkkv fvkfskipkt kfdfacglvf vcfmyginsv 181 klfthafiff tlahslkrkr liaafaiwsy giftlfinqk mknlpfnnia iilspmdqwy 241 kgivprwdff fnftllrlls ysmdflerwh eqlsrqpsid yddrrpefrk slsgstlqti 301 yesgknvlee kerlvaehhi qdynfinfia yityaplflv gpiitfndyl yqsenklpsl 361 tkknigfyal kvfsslllme iilhyiyvga iartkawnnd tplqqamial fnlnimylkl 421 lipwrlfrlw amvdgidape nmlrcvdnny stvgfwrawh tsfnkwviry iyvpfggsnn 481 kiltsfavfs fvaiwhdiql rvlfwgwltv llllgetyit ncfsryrfrs wyrfvcgiga 541 ainicmmmii nvygfclgae gtklllkgif nnshspeflt avmvslfiav qvmfeireee 601 krhginlkc // LOCUS NP_015136 414 aa linear PLN 30-JUN-2025 DEFINITION NADH kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015136 VERSION NP_015136.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184002.1 REFERENCE 1 (residues 1 to 414) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 414) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 414) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 414) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 414) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11247. Method: conceptual translation. FEATURES Location/Qualifiers source 1..414 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..414 /product="NADH kinase" /EC_number="2.7.1.86" /calculated_mol_wt="46116" Region 68..345 /region_name="NadK" /note="NAD kinase [Coenzyme transport and metabolism]; COG0061" /db_xref="CDD:439831" CDS 1..414 /gene="POS5" /locus_tag="YPL188W" /coded_by="NM_001184002.1:1..1245" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:12727869]" /experiment="EXISTENCE:direct assay:GO:0006741 NADP+ biosynthetic process [PMID:12727869]" /experiment="EXISTENCE:direct assay:GO:0042736 NADH kinase activity [PMID:12727869]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:20889970]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:7586028]" /note="Mitochondrial NADH kinase; preferentially phosphorylates NADH; required for the response to oxidative stress" /db_xref="GeneID:855913" /db_xref="SGD:S000006109" ORIGIN 1 mfvrvklnkp vkwyrfystl dshslklqsg skfvkikpvn nlrssssadf vsppnsklqs 61 liwqnplqnv yitkkpwtps treamvefit hlhesypevn vivqpdvaee isqdfksple 121 ndpnrphily tgpeqdivnr tdllvtlggd gtilhgvsmf gntqvppvla falgtlgfls 181 pfdfkehkkv fqevissrak clhrtrlech lkkkdsnssi vthamndifl hrgnsphltn 241 ldifidgefl trttadgval atptgstays lsaggsivsp lvpailmtpi cprslsfrpl 301 ilphsshiri kigsklnqkp vnsvvklsvd gipqqdldvg deiyvinevg tiyidgtqlp 361 ttrktendfn nskkpkrsgi ycvaktendw irginellgf nssfrltkrq tdnd // LOCUS NP_015137 165 aa linear PLN 30-JUN-2025 DEFINITION Mf(Alpha)1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015137 VERSION NP_015137.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184001.1 REFERENCE 1 (residues 1 to 165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 165) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11248. Method: conceptual translation. FEATURES Location/Qualifiers source 1..165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..165 /product="Mf(Alpha)1p" /calculated_mol_wt="18511" Region 1..85 /region_name="MF_alpha_N" /note="Mating factor alpha precursor N-terminus; pfam05436" /db_xref="CDD:398869" CDS 1..165 /gene="MF(ALPHA)1" /locus_tag="YPL187W" /coded_by="NM_001184001.1:1..498" /experiment="EXISTENCE:direct assay:GO:0000772 mating pheromone activity [PMID:6306574]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:776628]" /experiment="EXISTENCE:direct assay:GO:1903135 cupric ion binding [PMID:27476515]" /experiment="EXISTENCE:mutant phenotype:GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:3887136]" /experiment="EXISTENCE:mutant phenotype:GO:0000772 mating pheromone activity [PMID:3887136]" /note="Alpha-factor mating pheromone made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions" /db_xref="GeneID:855914" /db_xref="SGD:S000006108" ORIGIN 1 mrfpsiftav lfaassalaa pvntttedet aqipaeavig yldlegdfdv avlpfsnstn 61 ngllfintti asiaakeegv sldkreaeaw hwlqlkpgqp mykreaeaea whwlqlkpgq 121 pmykreadae awhwlqlkpg qpmykreada eawhwlqlkp gqpmy // LOCUS NP_015138 304 aa linear PLN 30-JUN-2025 DEFINITION Uip4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015138 VERSION NP_015138.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184000.1 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11249. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..304 /product="Uip4p" /calculated_mol_wt="34091" Region 1..87 /region_name="E_set_AMPKbeta_like_N" /note="N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; cd02859" /db_xref="CDD:199889" Site order(25,60,68,79..81,83,85) /site_type="other" /note="glycogen binding site [chemical binding]" /db_xref="CDD:199889" CDS 1..304 /gene="UIP4" /locus_tag="YPL186C" /coded_by="NM_001184000.1:1..915" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:11056382]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11056382|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006998 nuclear envelope organization [PMID:35171083]" /note="Protein required for nuclear envelope integrity; involved in distribution of nuclear pore complexes; interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope" /db_xref="GeneID:855916" /db_xref="SGD:S000006107" ORIGIN 1 mvtivfdhpa edfpelkiag eftnwegvpm kintssgkwe ykfdessvtk hndkdkvhfk 61 fidqngnwfa ddeypkevde hsnennvatl nneedggsag eekdegdkta hntnengsel 121 yyegpetptp slkgnvtfps pktaisqdgs afakettrke rkyehaplne vpverdpkee 181 nkelspnfsq eqtenkqdkg ldnlsegndn dntrvnedtd vtdtqesehe ingsdtentd 241 mseqeeiqki dkpadqnaks ivkegdante dyesvlkkll galgrffgsw fswlttkmss 301 seas // LOCUS NP_015140 612 aa linear PLN 30-JUN-2025 DEFINITION Mrn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015140 VERSION NP_015140.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183998.1 REFERENCE 1 (residues 1 to 612) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 612) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 612) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 612) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11250. Method: conceptual translation. FEATURES Location/Qualifiers source 1..612 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..612 /product="Mrn1p" /calculated_mol_wt="68533" Region 200..273 /region_name="RRM1_MRN1" /note="RNA recognition motif 1 (RRM1) found in RNA-binding protein MRN1 and similar proteins; cd12520" /db_xref="CDD:240964" Region 289..372 /region_name="RRM2_MRN1" /note="RNA recognition motif 2 (RRM2) found in RNA-binding protein MRN1 and similar proteins; cd12523" /db_xref="CDD:409943" Region 430..503 /region_name="RRM3_MRN1" /note="RNA recognition motif 3 (RRM3) found in RNA-binding protein MRN1 and similar proteins; cd12521" /db_xref="CDD:240965" Region 519..606 /region_name="RRM_SF" /note="RNA recognition motif (RRM) superfamily; cl17169" /db_xref="CDD:473069" CDS 1..612 /gene="MRN1" /locus_tag="YPL184C" /gene_synonym="PTR69" /coded_by="NM_001183998.1:1..1839" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0003730 mRNA 3'-UTR binding [PMID:36862555]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:23028530]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:23028530]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:23028530]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:23028530]" /experiment="EXISTENCE:genetic interaction:GO:0061158 3'-UTR-mediated mRNA destabilization [PMID:36862555]" /experiment="EXISTENCE:genetic interaction:GO:1990394 cellular response to cell wall damage [PMID:36862555]" /experiment="EXISTENCE:mutant phenotype:GO:0061158 3'-UTR-mediated mRNA destabilization [PMID:36862555]" /experiment="EXISTENCE:mutant phenotype:GO:1990394 cellular response to cell wall damage [PMID:36862555]" /note="mRNA-binding protein; binds to the 3'UTR of cell wall-related mRNAs and destabilizes these mRNAs during stress, acting antagonistically to Nab6p; links cell wall homeostasis to mitochondrial structure and function; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation" /db_xref="GeneID:855917" /db_xref="SGD:S000006105" ORIGIN 1 mvvsynnnnn nnnnnnnnni snnnnnnnmf ppfpssddfa myqqssssgp yqetyasgpq 61 nfgdavypmn gnftllpsdf trepndsffy endgifdyqr iqqqptqfqt kqrndsqqqr 121 fsqeqnfeid nevvhnnnry yeyerssnev spfddenpnv lsdgmsptim atatavtnan 181 aplpvnaqan nplnftsaps rtvylgnvpp nlsvkelldh vrsgvvedvk iipekmcafv 241 sfidesaall fhsdailkrl nigdrdikig wgkptridpi vaaristdga trnvyigrmt 301 iegeeshlse eqlrvdleey geidcikiik ekgiafihfa silnaikvvt nlpirnpyyq 361 nkrifygkdr cafitktqqh naaqflgvqp gmehmiefsd refisnallq qsaaaaaiat 421 saggpnnlgn rtvylgslpk dvkieeicna vrggllqsik llndryvcfv tfidptaaaq 481 fyamsslygf tvqkkrckvg wgkhsgplpn alalavsnga srnvyvgnid fvgdslrder 541 vftesnlrhi fqqygeveqi nflpeknccf inytnisnai laldkiksnp yfkdlkinfg 601 kdrcgnvphq sr // LOCUS NP_015141 93 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein bL36m RTC6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015141 VERSION NP_015141.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184317.1 REFERENCE 1 (residues 1 to 93) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 93) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 93) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 93) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11251. Method: conceptual translation. FEATURES Location/Qualifiers source 1..93 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..93 /product="mitochondrial 54S ribosomal protein bL36m RTC6" /calculated_mol_wt="10567" Region 56..93 /region_name="Ribosomal_L36" /note="Ribosomal protein L36; pfam00444" /db_xref="CDD:459811" CDS 1..93 /gene="RTC6" /locus_tag="YPL183W-A" /gene_synonym="bL36m; TAE4" /coded_by="NM_001184317.1:1..282" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:38493895]" /experiment="EXISTENCE:genetic interaction:GO:0042254 ribosome biogenesis [PMID:20691087]" /experiment="EXISTENCE:mutant phenotype:GO:0042254 ribosome biogenesis [PMID:20691087]" /note="Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855918" /db_xref="SGD:S000007224" ORIGIN 1 mflqtlrltm prmflhmkps pititractv psllsvaapq palvaanrpl vfnrgfkvrt 61 svkkfcsdcy lvrrkgrvyi ycksnkkhkq rqg // LOCUS NP_015142 1013 aa linear PLN 30-JUN-2025 DEFINITION tRNA (34-2'-O)-methyltransferase regulator RTT10 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015142 VERSION NP_015142.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183997.1 REFERENCE 1 (residues 1 to 1013) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1013) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1013) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1013) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1013) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1013) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1013) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11252. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1013 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1013 /product="tRNA (34-2'-O)-methyltransferase regulator RTT10" /calculated_mol_wt="114331" Region <20..300 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 51..90 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 95..126 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 224..261 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 275..308 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 676..973 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(682,686,694..695,709..710,727,731,737..738,750..751, 783,788,794..795,808,831,836,842..843,880..881,903,907, 913..914,927..928,952,957,963..964) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" CDS 1..1013 /gene="RTT10" /locus_tag="YPL183C" /gene_synonym="ERE2; TRM734" /coded_by="NM_001183997.1:1..3042" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:21880895]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:21880895]" /experiment="EXISTENCE:mutant phenotype:GO:0002130 wobble position ribose methylation [PMID:22912484]" /experiment="EXISTENCE:mutant phenotype:GO:0032456 endocytic recycling [PMID:21880895]" /experiment="EXISTENCE:physical interaction:GO:0002130 wobble position ribose methylation [PMID:22912484]" /note="WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; interacts with Trm7p for 2'-O-methylation of N34 of substrate tRNAs; has a role in regulation of Ty1 transposition; human ortholog is WDR6" /db_xref="GeneID:855919" /db_xref="SGD:S000006104" ORIGIN 1 mkdlshygpa lcvkfyndyv lagygpfihv ydyhsatlin kcrlfhynkv hglslssegk 61 ilaygarsvt iveledvlkk eslvdferin sdwitgatfs fdnlqiyllt cynkvlicdl 121 ncevlfrksl ggersilysg iikvfgpdkv yvnagtvmgg viiwdlfset kihnllgheg 181 sifyvnlsnn gryvascsdd rsirlwdlet gkqlsvgwsh tariwnlmff dndsklisvs 241 edctcrvwni iesrenvael sisnvyevhl iksiwgvdvk ddemiavtsg ndgrlklidl 301 lqlkrhgdee tsfslddiak qcgdifekne sikgfqwfsf gviaitslgk ilkysdvtkq 361 wkllltnekf nsypitngiq tqniavfsnn ksdillikfs kdsadiiete efhldelskt 421 nnclvteydd dsflltlqsp nprekfvcle islqnlkiks khcfnkpenf ssscltsfrn 481 hilvgsrfst lviynlldes eepfiirrls pgdtttsief vedkdnsavf svtnrdgyyv 541 fieltknsle egpyrlsykv lhsnkmmkgf legaffnskg eyitygfkss lfylynetnc 601 yelasevcgg shrlwnlaki tdghvlmyik asrfhlrkiy nsivpetlen gvhgreirdi 661 sicpvsntnt ndnfkdghif ctasedttik lgyfnnrtgk vqnfwtqrkh vsglqrcqfi 721 nhklmisssa reelflweln dkynkrpymt irqalpvstn nsdlrimdfd vkfisqsgdf 781 llvtvysdst ikiwhyrenq nkfdlimqgr yktcclfnvv fialkeellv visptdghlv 841 vyniteyvpf svdpisgdlv dhkldatisn lpapvaqlpv hqsgvksldy vanatrtsat 901 iltggddngl glsnlkldds nkvtlktsdf iaaaasstit sgmlinggke vittsvdqvi 961 raweitagkl slvdkkrttv adtgsleiis ndedadsekt lliggvglsi wkk // LOCUS NP_015144 506 aa linear PLN 30-JUN-2025 DEFINITION Cti6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015144 VERSION NP_015144.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183995.1 REFERENCE 1 (residues 1 to 506) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 506) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 506) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 506) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11253. Method: conceptual translation. FEATURES Location/Qualifiers source 1..506 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..506 /product="Cti6p" /calculated_mol_wt="56922" Region 74..120 /region_name="PHD_MLL5" /note="PHD finger found in mixed lineage leukemia 5 (MLL5); cd15550" /db_xref="CDD:277025" Site order(85,87..91,93,98,111..115) /site_type="other" /note="histone H3 binding site [polypeptide binding]" /db_xref="CDD:277025" Region <333..441 /region_name="Apt1" /note="Golgi-body localization protein domain; pfam10351" /db_xref="CDD:463055" CDS 1..506 /gene="CTI6" /locus_tag="YPL181W" /gene_synonym="RXT1" /coded_by="NM_001183995.1:1..1521" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:19040720|PMID:16286007|PMID:16314178|PMID:16286008]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:17142463]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:19417103]" /experiment="EXISTENCE:mutant phenotype:GO:0045893 positive regulation of DNA-templated transcription [PMID:12086626]" /experiment="EXISTENCE:mutant phenotype:GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation [PMID:16286008]" /experiment="EXISTENCE:mutant phenotype:GO:0061188 negative regulation of rDNA heterochromatin formation [PMID:16286008]" /note="Component of the Rpd3L histone deacetylase complex; relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain" /db_xref="GeneID:855920" /db_xref="SGD:S000006102" ORIGIN 1 mestaivpkg pvvgsedmek aeviasgstd iisttstatt taaigsvqee svkqedvpme 61 ggegeveeee getrcicgel dtpddsgffi qceqcsswqh gycvsitqdn apdkywceqc 121 rpelhqlftt dtgearsiyk pvqekrrqsr rkarsaaask shaaneaeks prntsntddn 181 vddigdeede vedeasaval akdgntrssr rrrrnsmdda stdqysldpg dsdkklldrk 241 ratfmareek qyqrmlekal kesrrtshqe dpesyendad iyqgdtdnhn gttrlqtdvm 301 ltegkpdsvt nddmkeslrp skeqsmektn dvekeasqek esstgsaqdt ektdepilpl 361 tsisssedds rkassrgskr vskparkgnr trrsntssdt nqnrrsadig tdkpvkprlp 421 pqrtslnemr rrvsailefi srtqwelsed qsdreefvrf venqhfvekv dtiyngynes 481 lsmmddltre lllwekkysn ntnaiq // LOCUS NP_015145 799 aa linear PLN 30-JUN-2025 DEFINITION Tco89p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015145 VERSION NP_015145.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183994.1 REFERENCE 1 (residues 1 to 799) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 799) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 799) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 799) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 799) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11254. Method: conceptual translation. FEATURES Location/Qualifiers source 1..799 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..799 /product="Tco89p" /calculated_mol_wt="88714" Region 30..732 /region_name="TCO89" /note="TORC1 subunit TCO89; pfam10452" /db_xref="CDD:371063" CDS 1..799 /gene="TCO89" /locus_tag="YPL180W" /coded_by="NM_001183994.1:1..2400" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:19748353|PMID:26928762|PMID:17560372]" /experiment="EXISTENCE:mutant phenotype:GO:0006071 glycerol metabolic process [PMID:10931309]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:17298473]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:14736892]" /experiment="EXISTENCE:physical interaction:GO:0001558 regulation of cell growth [PMID:14736892]" /experiment="EXISTENCE:physical interaction:GO:0031931 TORC1 complex [PMID:14736892]" /note="Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p); regulates global H3K56ac; TORC1 complex regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin" /db_xref="GeneID:855922" /db_xref="SGD:S000006101" ORIGIN 1 mvhrgrtlks dtdvtslnas tvshqskpfr qfstrsraks nasfkglrrv lthdgtldnd 61 yfnkhnvsqk ckssdalfrk rtisglnmta ltrvksnqgk rsasfhspvh ntllspknss 121 hsntgtagfg lkprrskstq svlslrdaqe skksesttde evecfsedni edgkvnndkv 181 iaehvmpeek knvqqlnqne lqspdsideq eedksgtdgk enhravslpl phlssnnyfg 241 esshsiehqk dgetspssie tklnatsvin eegqskvtke adiddlsshs qnlraslvka 301 gdniseapyd kekkildvgn tlaahksnqk pshsdeqfdq edhidaprsn ssrksdssfm 361 slrrqsskqh kllneeedli kpddissagt kdieghslle nyapnmilsq stgverrfen 421 sssiqnslgn eihdsgehma sgdtfneldd gklrkskkng grsqlgqnip nsqstfptia 481 nigskdnnvp qhnfstsiss ltnnlrraap esfhgsrmnn ifhkkgnqnl llrsndlnkn 541 saapasplsn ehitsstnsg sdanrqsnsg akfnsfaqfl ksdgidaesr tqrklwlqre 601 nsimdlssqn dgsdsifmag nidakrefer isheysnvkr fynpldeall rvqpiitgna 661 nnirkkshnd aqsiahsssd tdhkdeddll ftnydkkfdd lyphlasaki qavlsgiwks 721 esylfnkdvn pinknrttst nhsvghtasq narnllrgpm gssttlhhqr vinslqpttr 781 avnrrmenvg ymhtqpqqr // LOCUS NP_015146 549 aa linear PLN 30-JUN-2025 DEFINITION protein-serine/threonine phosphatase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015146 VERSION NP_015146.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183993.1 REFERENCE 1 (residues 1 to 549) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 549) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 549) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 549) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 549) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11255. Method: conceptual translation. FEATURES Location/Qualifiers source 1..549 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..549 /product="protein-serine/threonine phosphatase" /EC_number="3.1.3.16" /calculated_mol_wt="61290" Region 239..535 /region_name="MPP_PP1_PPKL" /note="PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain; cd07414" /db_xref="CDD:277359" Site order(301,303,329,333,361..362,366..367,371,410,432..434, 443,457..459,485,509..513) /site_type="active" /db_xref="CDD:277359" Site order(301,303,329,361,410,485) /site_type="metal-binding" /note="metal binding site [ion binding]" /db_xref="CDD:277359" Site order(333,366..367,371,432..434,443,457..459,509..513) /site_type="other" /note="natural toxin binding site [chemical binding]" /db_xref="CDD:277359" Site order(416,418,435,440,453,462,470..471,473..475,477..479, 494,498,525..526,528,530,532) /site_type="other" /note="MYPT1 binding site [polypeptide binding]" /db_xref="CDD:277359" CDS 1..549 /gene="PPQ1" /locus_tag="YPL179W" /gene_synonym="SAL6" /coded_by="NM_001183993.1:1..1650" /experiment="EXISTENCE:direct assay:GO:0004721 phosphoprotein phosphatase activity [PMID:24309106]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0090029 negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion [PMID:24309106]" /note="Protein phosphatase that regulates the mating response; negatively regulates the MAP kinase signaling cascade during mating; member of the serine/threonine phosphatase PP1 family" /db_xref="GeneID:855923" /db_xref="SGD:S000006100" ORIGIN 1 mrrspsrsnn nfavpncstn snssqqqltt psddlnsnep ndpddsrslp tikkfnnkhs 61 innyntlasa gknnnnkras ndnllipgen ahkqkiytkd enlkslyldi dvsvakalss 121 satapklint artsstttat tsnniltsps yresnyssps sysfssyyss atsassstss 181 flkssglssr vkspsssvka gsfgapsspt sgipnpkssk kpiflrrysh dtssnegldi 241 dvaiekllqv gesreitkts kkknfpfhsw eiqlicyhar eiflnqptll rlqapikvvg 301 dvhgqfndll rilklsgvps dtnylflgdy vdrgknslet illllcykik ykdnffmlrg 361 nhesanvtkm ygfydeckrr lsskvwkmfv dvfntlplaa iiqdkifcvh ggispdlhdm 421 kqiekvarpt dipesglvtd llwsdpdpqv tdwsendrgv sytfskrnvl dfcakfkfdl 481 ilrghmvved gyeffarkkf vtifsapnyc gefhnwgavm svttgmmcsf ellkpralkn 541 kkklyktkv // LOCUS NP_015147 208 aa linear PLN 30-JUN-2025 DEFINITION nuclear cap-binding protein subunit CBC2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015147 VERSION NP_015147.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183992.1 REFERENCE 1 (residues 1 to 208) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 208) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 208) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 208) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11256. Method: conceptual translation. FEATURES Location/Qualifiers source 1..208 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..208 /product="nuclear cap-binding protein subunit CBC2" /calculated_mol_wt="23643" Region 48..125 /region_name="RRM_NCBP2" /note="RNA recognition motif (RRM) found in nuclear cap-binding protein subunit 2 (CBP20) and similar proteins; cd12240" /db_xref="CDD:409686" Site order(49,89,91,118,120..122) /site_type="other" /note="chemical substrate binding site [chemical binding]" /db_xref="CDD:409686" Site order(56,59..61,63..65,68..69,71,73,75,95,102,105..106, 108..111,113..114) /site_type="other" /note="subunit interface [polypeptide binding]" /db_xref="CDD:409686" CDS 1..208 /gene="CBC2" /locus_tag="YPL178W" /gene_synonym="CBP20; MUD13; SAE1" /coded_by="NM_001183992.1:1..627" /experiment="EXISTENCE:direct assay:GO:0000243 commitment complex [PMID:8682299]" /experiment="EXISTENCE:direct assay:GO:0000339 RNA cap binding [PMID:8682299]" /experiment="EXISTENCE:direct assay:GO:0005846 nuclear cap binding complex [PMID:8811086]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:8682299]" /note="Small subunit of the heterodimeric cap binding complex with Sto1p; interacts with Npl3p, possibly to package mRNA for export from the nucleus; may have a role in telomere maintenance; contains an RNA-binding motif" /db_xref="GeneID:855925" /db_xref="SGD:S000006099" ORIGIN 1 msleefdevk ydhstkrldt psryllrkar rnpnglqelr esmksstiyv gnlsfytsee 61 qiyelfskcg tikriimgld rfkftpcgfc fiiyscpdea lnalkylsdt kldektitid 121 ldpgfedgrq fgrgksggqv sdelrfdfda srggfaipfa ervgvphsrf dnsssqsntn 181 nyipppdamg tfrpgfdeer eddnyvpq // LOCUS NP_015148 306 aa linear PLN 30-JUN-2025 DEFINITION Cup9p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015148 VERSION NP_015148.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183991.1 REFERENCE 1 (residues 1 to 306) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 306) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 306) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 306) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 306) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11257. Method: conceptual translation. FEATURES Location/Qualifiers source 1..306 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..306 /product="Cup9p" /calculated_mol_wt="34523" Site order(165,168,211,214..215,219) /site_type="other" /note="specific DNA base contacts [nucleotide binding]" /db_xref="CDD:238039" Region 181..219 /region_name="Homeobox_KN" /note="Homeobox KN domain; pfam05920" /db_xref="CDD:428673" CDS 1..306 /gene="CUP9" /locus_tag="YPL177C" /coded_by="NM_001183991.1:1..921" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:9427760]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:9427760]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17005992|PMID:10850718|PMID:9427760|PMID:18708352]" /experiment="EXISTENCE:mutant phenotype:GO:2000877 negative regulation of oligopeptide transport [PMID:17005992]" /experiment="EXISTENCE:mutant phenotype:GO:2000879 negative regulation of dipeptide transport [PMID:10850718|PMID:9427760|PMID:17005992|PMID:18708352]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:18708352]" /note="Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855926" /db_xref="SGD:S000006098" ORIGIN 1 mnynceiqnr nsknvdnqvs lppiqvlfns iekrsmpela fsnieyshgn lrssteeqny 61 papvllpqhh siaypainsg gtsttatpta stvetsktss samdtqsqyg sskksksasd 121 dakpcyksap iyeiinkekd agaqynrpfs dfvesksrrk qnsgrrsnlp ketvqilntw 181 llnhlnnpyp tqqekrelli ktgltkiqls nwfinvrrrk ifsdyytlvn sipndnannt 241 pvervqnvsa yhntlsatnn tmydatstcs tdyelskrfa hapvtrrkkl idrleelkkl 301 snpdmn // LOCUS NP_015149 783 aa linear PLN 30-JUN-2025 DEFINITION Tre1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015149 VERSION NP_015149.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183990.1 REFERENCE 1 (residues 1 to 783) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 783) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 783) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 783) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 783) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 783) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 783) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11258. Method: conceptual translation. FEATURES Location/Qualifiers source 1..783 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..783 /product="Tre1p" /calculated_mol_wt="88625" Region 221..374 /region_name="PA" /note="Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At...; cl28883" /db_xref="CDD:333703" Site 313..315 /site_type="other" /note="PA/protease or protease-like domain interface [polypeptide binding]" /db_xref="CDD:238300" Region 402..617 /region_name="M28_PMSA_TfR_like" /note="M28 Zn-peptidase Transferrin Receptor-like family; cd03874" /db_xref="CDD:349871" Site order(417..418,420,465,467,486..487,489,491..494,614) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:349871" Region 642..770 /region_name="TFR_dimer" /note="Transferrin receptor-like dimerization domain; pfam04253" /db_xref="CDD:461238" CDS 1..783 /gene="TRE1" /locus_tag="YPL176C" /coded_by="NM_001183990.1:1..2352" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:16456538|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:19369420]" /note="Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitination and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication" /db_xref="GeneID:855927" /db_xref="SGD:S000006097" ORIGIN 1 mvntrgyttl pnveepanns qdelnsqdfe qaigmpsepp vyveemgmee pqapeafsek 61 vqrfrmcfen nvvipvkknv vdplaqmisl asekfdlfls kignvmvmrr ifyimmmsii 121 aaliiasdrl pngkargsng sfsdhdlllq yarksidlsk ierdleyiss mphmsgtsgd 181 aairhyikes fdkngirlag eeefmaysny pgnvslrvys kddtegfdip lneenfnpms 241 hngqlnnipv iyankasldd masmqdqgll ngdfillvhy gdyvfqqmlt aqeygakaii 301 fisepyqdnk dviqmksval pqygtgdalt pewegsirdp idateakclp kipsipisan 361 qgdkilails dtgvkfsnnl fsgslndcrl dllvqtaire rhpvhdivgk iegseqagra 421 iviaaprnsa sygtmypsfg tvvllsliql yqemvykfdw kplrniyfis fggsefneag 481 atelmekrte alkseiytii dvgqigiwdd snnleiqchp llvdlfqknm tsrkfnvkvd 541 nvhqfgdwtp ylaqgipvai isspgvmnre hpiytvedkf dfikdklrdk kkgevlseim 601 lylvekslel iddpfipfsi snyvdflstt lkdlqkecpd tvnfdevflg ttlwentklq 661 fekwksewte lmygagtyie ptiiainrws wnyllsligv tqcleeglmd rtfyknvifg 721 pklwvdkgdp lrswtfpeir dtiaikdwss vqvqantlgt ilqntaryfl enknlhgint 781 nef // LOCUS NP_015150 452 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol N-acetylglucosaminyltransferase SPT14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015150 VERSION NP_015150.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183989.1 REFERENCE 1 (residues 1 to 452) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 452) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 452) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 452) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11259. On Aug 9, 2000 this sequence version replaced NP_015150.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..452 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..452 /product="phosphatidylinositol N-acetylglucosaminyltransferase SPT14" /EC_number="2.4.1.198" /calculated_mol_wt="51111" Region 4..408 /region_name="GT4_PIG-A-like" /note="phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; cd03796" /db_xref="CDD:340827" Site order(18,208..210,272,294) /site_type="other" /note="putative ADP-binding pocket [chemical binding]" /db_xref="CDD:340827" CDS 1..452 /gene="SPT14" /locus_tag="YPL175W" /gene_synonym="CWH6; GPI3" /coded_by="NM_001183989.1:1..1359" /experiment="EXISTENCE:curator inference:GO:0006506 GPI anchor biosynthetic process [PMID:10970797]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0005783 endoplasmic reticulum [PMID:9079905]" /experiment="EXISTENCE:mutant phenotype:GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity [PMID:10970797]" /note="UDP-glycosyltransferase subunit of the GPI-GnT complex; UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins" /db_xref="GeneID:855928" /db_xref="SGD:S000006096" ORIGIN 1 mgfniamlcd ffypqlggve fhiyhlsqkl idlghsvvii thaykdrvgv rhltnglkvy 61 hvpffvifre ttfptvfstf piirnillre qiqivhshgs astfahegil hantmglrtv 121 ftdhslygfn nltsiwvnkl ltftltnidr vicvsntcke nmivrtelsp diisvipnav 181 vsedfkprdp tggtkrkqsr dkivivvigr lfpnkgsdll triipkvcss hedvefivag 241 dgpkfidfqq mieshrlqkr vqllgsvphe kvrdvlcqgd iylhasltea fgtilveaas 301 cnllivttqv ggipevlpne mtvyaeqtsv sdlvqatnka iniirskald tssfhdsvsk 361 mydwmdvakr tveiytniss tssaddkdwm kmvanlykrd giwakhlyll cgiveymlff 421 llewlyprde idlapkwpkk tvsnetkear et // LOCUS NP_015151 868 aa linear PLN 30-JUN-2025 DEFINITION Nip100p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015151 VERSION NP_015151.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183988.1 REFERENCE 1 (residues 1 to 868) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 868) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 868) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 868) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 868) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11260. Method: conceptual translation. FEATURES Location/Qualifiers source 1..868 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..868 /product="Nip100p" /calculated_mol_wt="100159" Region 12..828 /region_name="NIP100" /note="Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]; COG5244" /db_xref="CDD:227569" CDS 1..868 /gene="NIP100" /locus_tag="YPL174C" /gene_synonym="PAC13" /coded_by="NM_001183988.1:1..2607" /experiment="EXISTENCE:direct assay:GO:0005869 dynactin complex [PMID:9658168]" /experiment="EXISTENCE:mutant phenotype:GO:0000132 establishment of mitotic spindle orientation [PMID:9658168]" /note="Large subunit of the dynactin complex; dynactin is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)" /db_xref="GeneID:855929" /db_xref="SGD:S000006095" ORIGIN 1 mrnagvqvdt nmqkislqdt vlvnemkgrv kfigetqfak giwygieldk plgkndgsan 61 giryfdidlk kansnggyyg lfckkdtlqf ykpdddehsl lngnaaqeti knlqvkcesl 121 asklnkikie nhelktsvek lstnetvlls kisrldklvk elkvengnmk thldnfnhll 181 dasdsvmapd ldkgtllers hllqglldqt klsydkamkv qedlleentq lleenavlsk 241 kisdlglqlq qtnntigdla lqieaqskss nivdkltndn illtsnikal nneleelqak 301 ekldenlrit yeqleqelrl qlsnlqsale nekeiagtyi eensrlkatl esieaktshk 361 fqslelkvnt lqeelyqnkl lkkfyqiyep faqphlaals sqlqylaevi esenfgklen 421 ieihiilkvl ssisyalhiy tikntpdhle ttlqcfkvni apismwlsef lqrkfsskqe 481 tafsicqfle dnkfldkdvt lilkilhpil ettvpkllaf lrtnsnfndn dtlcligsly 541 erslsliari dkligkeeis kqdnrlflyp scditlssil tilfsdalfl rqdykrissl 601 kklevffqgi esllenitif peqpsqqtsd sesqcnikeg nfsnsllsdr lneenirlke 661 vlvqkenmlt eletkikiii grdlerktle eniktlkvel nnkneencgk teilnklkee 721 nfnlvnrlkn melklyqikd nntlnkiyld rekvdrvnlv seimelreti rrqikeqkrv 781 sidfswldel pavenkqpfk ehinhsldtl giemfnfvst srildlkldq plaedelwhe 841 rdhsyisylk rkrknirlks qnvvtyyk // LOCUS NP_015152 297 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein uL24m MRPL40 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015152 VERSION NP_015152.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183987.1 REFERENCE 1 (residues 1 to 297) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 297) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 297) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 297) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11261. Method: conceptual translation. FEATURES Location/Qualifiers source 1..297 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..297 /product="mitochondrial 54S ribosomal protein uL24m MRPL40" /calculated_mol_wt="33620" Region 65..96 /region_name="KOW" /note="KOW motif; pfam00467" /db_xref="CDD:425698" CDS 1..297 /gene="MRPL40" /locus_tag="YPL173W" /gene_synonym="uL24m" /coded_by="NM_001183987.1:1..894" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:9151978|PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552|PMID:9151978]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:9151978|PMID:12392552]" /note="Mitochondrial ribosomal protein of the large subunit" /db_xref="GeneID:855930" /db_xref="SGD:S000006094" ORIGIN 1 msgsyqhlsn vgsrvmkrlg nrpknflphs ekfikkstpe fmksdlkevd ektsfkseke 61 wkfipgdrvv vmsgaskgni aviksfdkrt nsfildengp tktvpvpkqf wlegqtshmi 121 tipvsilgkd lrlvadidde ktpgktrtva vrdvsfngsy ydadykkvmp yrcvkgqpdl 181 iipwpkpdpi dvqtnlatdp viareqtfwv dsvvrnpipk kaipsirnph skykrgtlta 241 kdiaklvape mpltevrksh laekkelaer evpklteedm eaigarvfef lekqkre // LOCUS NP_015153 462 aa linear PLN 30-JUN-2025 DEFINITION protoheme IX farnesyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015153 VERSION NP_015153.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183986.1 REFERENCE 1 (residues 1 to 462) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 462) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 462) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 462) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11262. Method: conceptual translation. FEATURES Location/Qualifiers source 1..462 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..462 /product="protoheme IX farnesyltransferase" /EC_number="2.5.1.141" /calculated_mol_wt="52017" Region 147..442 /region_name="cyoE_ctaB" /note="protoheme IX farnesyltransferase; TIGR01473" /db_xref="CDD:273645" CDS 1..462 /gene="COX10" /locus_tag="YPL172C" /coded_by="NM_001183986.1:1..1389" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0006784 heme A biosynthetic process [PMID:8118433]" /note="Heme A:farnesyltransferase; catalyzes first step in conversion of protoheme to heme A prosthetic group required for cytochrome c oxidase activity; human ortholog COX10 can complement yeast cox10 null mutant; human ortholog COX10 is associated with mitochondrial disorders" /db_xref="GeneID:855931" /db_xref="SGD:S000006093" ORIGIN 1 msyfprtyah lmrnvlahnk gniylqigtq lhdtqikirf ngvryisrnh ggkqqhinta 61 pieftpnfgy gdrtsncnkk vestamktlr ctddistssg seattdastq lpfnvklvdp 121 mvrkskrpsh aiseglnmkt lkkkvimpyl qltkprltil vmlsaicsya lspypasvne 181 llcltvgttl csgsanainm grepefdrqm vrtqarpvvr gdvtptqafe faaligtlgv 241 silyfgvnpt vailgasnia lygwaytsmk rkhiintwlg alvgmvpplm gwaaasplsh 301 pgswclagll fawqfphfnt lshnirneyk nagyvmtawk npllnarvsl rysilmfplc 361 fglsyfnitd wyyqidsgli nawltfwafk fywqqrinys aktlkdnvkf nkglsvaniy 421 arktfmasvl hlpaililai ihkkgrwdwi ypgeakrpqe rf // LOCUS NP_015154 400 aa linear PLN 30-JUN-2025 DEFINITION NADPH dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015154 VERSION NP_015154.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183985.1 REFERENCE 1 (residues 1 to 400) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 400) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 400) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 400) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 400) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11263. Method: conceptual translation. FEATURES Location/Qualifiers source 1..400 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..400 /product="NADPH dehydrogenase" /EC_number="1.6.99.1" /calculated_mol_wt="44790" Region 16..372 /region_name="OYE_like_FMN" /note="Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; cd02933" /db_xref="CDD:239243" Site order(36,38,73,115,244,325,346,348..350) /site_type="other" /note="FMN binding site [chemical binding]" /db_xref="CDD:239243" Site order(36,38,73,115,117,124,192,195,197,244,251,325,346, 348..349) /site_type="active" /db_xref="CDD:239243" Site order(38,117,192,195,197,349) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:239243" Site 197 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:239243" CDS 1..400 /gene="OYE3" /locus_tag="YPL171C" /gene_synonym="ZRG6" /coded_by="NM_001183985.1:1..1203" /experiment="EXISTENCE:direct assay:GO:0003959 NADPH dehydrogenase activity [PMID:7836424]" /experiment="EXISTENCE:mutant phenotype:GO:0006915 apoptotic process [PMID:17897954]" /note="Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death" /db_xref="GeneID:855932" /db_xref="SGD:S000006092" ORIGIN 1 mpfvkgfepi slrdtnlfep ikigntqlah ravmppltrm rathpgnipn kewaavyygq 61 raqrpgtmii tegtfispqa ggydnapgiw sdeqvaewkn iflaihdcqs fawvqlwslg 121 wasfpdvlar dglrydcasd rvymnatlqe kakdannleh sltkddikqy ikdyihaakn 181 siaagadgve ihsangylln qfldphsnkr tdeyggtien rarftlevvd alietigper 241 vglrlspygt fnsmsggaep giiaqysyvl gelekrakag krlafvhlve prvtdpslve 301 gegeysegtn dfaysiwkgp iiragnyalh pevvreqvkd prtligygrf fisnpdlvyr 361 leeglplnky drstfytmsa egytdyptye eavdlgwnkn // LOCUS NP_015155 152 aa linear PLN 30-JUN-2025 DEFINITION Dap1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015155 VERSION NP_015155.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183984.1 REFERENCE 1 (residues 1 to 152) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 152) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 152) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 152) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 152) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11264. Method: conceptual translation. FEATURES Location/Qualifiers source 1..152 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..152 /product="Dap1p" /calculated_mol_wt="16626" Region 46..108 /region_name="Cyt-b5" /note="Cytochrome b5-like Heme/Steroid binding domain; pfam00173" /db_xref="CDD:459698" CDS 1..152 /gene="DAP1" /locus_tag="YPL170W" /coded_by="NM_001183984.1:1..459" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:17954932]" /experiment="EXISTENCE:direct assay:GO:0020037 heme binding [PMID:15713626]" /experiment="EXISTENCE:genetic interaction:GO:0032443 regulation of ergosterol biosynthetic process [PMID:15713626]" /experiment="EXISTENCE:mutant phenotype:GO:0032443 regulation of ergosterol biosynthetic process [PMID:17954932]" /note="Heme-binding protein; involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis" /db_xref="GeneID:855933" /db_xref="SGD:S000006091" ORIGIN 1 msfiknllfg gvktsedptg ltgngasntn dsnkgsepvv agnffprtls kfnghddeki 61 fiairgkvyd ctrgrqfygp sgpytnfagh dasrglalns fdldvikdwd qpidplddlt 121 keqidaldew qehfenkypc igtlipepgv nv // LOCUS NP_015156 599 aa linear PLN 30-JUN-2025 DEFINITION Mex67p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015156 VERSION NP_015156.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183983.1 REFERENCE 1 (residues 1 to 599) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 599) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 599) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 599) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 599) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11265. Method: conceptual translation. FEATURES Location/Qualifiers source 1..599 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..599 /product="Mex67p" /calculated_mol_wt="67221" Region 23..92 /region_name="RRM_9" /note="RNA recognition motif; pfam18444" /db_xref="CDD:408240" Region 119..163 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275382" Region <155..256 /region_name="PPP1R42" /note="protein phosphatase 1 regulatory subunit 42; cl42388" /db_xref="CDD:455733" Region 164..189 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275382" Region 190..217 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275382" Region 218..242 /region_name="leucine-rich repeat" /note="leucine-rich repeat [structural motif]" /db_xref="CDD:275382" Region 537..597 /region_name="TAP_C" /note="C-terminal domain of vertebrate Tap protein; smart00804" /db_xref="CDD:197882" Site order(561,565,568..569,571..574,579,583,587,590,592) /site_type="other" /note="peptide binding site [polypeptide binding]" /db_xref="CDD:270527" CDS 1..599 /gene="MEX67" /locus_tag="YPL169C" /coded_by="NM_001183983.1:1..1800" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:29212662]" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:12524544]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:31753862]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0015288 porin activity [PMID:31753862]" /experiment="EXISTENCE:direct assay:GO:0017070 U6 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030619 U1 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030620 U2 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030621 U4 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:direct assay:GO:0030623 U5 snRNA binding [PMID:31189105]" /experiment="EXISTENCE:genetic interaction:GO:0000055 ribosomal large subunit export from nucleus [PMID:17434126]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:17434126|PMID:31439809]" /experiment="EXISTENCE:mutant phenotype:GO:0000056 ribosomal small subunit export from nucleus [PMID:22956913]" /experiment="EXISTENCE:mutant phenotype:GO:0006406 mRNA export from nucleus [PMID:10722667]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:29212662]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:29212662]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:27385342]" /experiment="EXISTENCE:mutant phenotype:GO:0071528 tRNA re-export from nucleus [PMID:33074312]" /experiment="EXISTENCE:physical interaction:GO:0042272 nuclear RNA export factor complex [PMID:9774696]" /note="Poly(A) RNA binding protein involved in nuclear mRNA export; component of the nuclear pore and nuclear RNA export factor; ubiquitin-associated (UBA) domain interacts with Mip6p; ortholog of human TAP" /db_xref="GeneID:855934" /db_xref="SGD:S000006090" ORIGIN 1 msgfhnvgni nmmaqqqmqq nrikisvrnw qnatmndlin fisrnarvav ydahvegplv 61 igyvnskaea eslmkwngvr fagsnlkfel ldnngasagt sdtisflrgv llkrydpqtk 121 llnlgalhsd peliqkgvfs sistqskmfp ammklastek slivesvnla dnqlkdisai 181 stlaqtfpnl knlclannqi frfrslevwk nkfkdlrell mtnnpittdk lyrtemlrlf 241 pklvvldnvi vrdeqklqtv yslpmkiqqf ffendalgqs stdfatnfln lwdnnreqll 301 nlyspqsqfs vsvdstipps tvtdsdqtpa fgyymsssrn iskvsseksi qqrlsigqes 361 insifktlpk tkhhlqeqpn eysmetisyp qingfvitlh gffeetgkpe lesnkktgkn 421 nyqknrrynh gynstsnnkl skksfdrtwv ivpmnnsvii asdlltvray stgawktasi 481 aiaqppqqqa svlpqvasmn pnittppqpq psvvpggmsi pgapqgamvm aptlqlppdv 541 qsrlnpvqle llnklhletk lnaeytfmla eqsnwnyeva ikgfqssmng ipreafvqf // LOCUS NP_015157 430 aa linear PLN 30-JUN-2025 DEFINITION Mrx4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015157 VERSION NP_015157.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183982.1 REFERENCE 1 (residues 1 to 430) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 430) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 430) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 430) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 430) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11266. Method: conceptual translation. FEATURES Location/Qualifiers source 1..430 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..430 /product="Mrx4p" /calculated_mol_wt="48696" CDS 1..430 /gene="MRX4" /locus_tag="YPL168W" /coded_by="NM_001183982.1:1..1293" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Protein that associates with mitochondrial ribosome; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated" /db_xref="GeneID:855935" /db_xref="SGD:S000006089" ORIGIN 1 mtvlytsasl kkmkclafnm gmncvrtvsh arsggakfgg rnvfnifdsk tpdsvrikaf 61 kntiyqsamg kgktkfsame inlitslvrg ykgegkknai nplqtnvqil nklllthrlt 121 dkdilegmnl aagpvnvaip rditpqeekk kvelrnrkae nmdlhpsrkm hikellhsln 181 ldmcndeevy qkislylqkn eesrtsvgas qqnhvdidin slkrylqnie kkarqksaid 241 kqkknqariy qwntqsfsei vplsagnilf krepnrlwkr lqngisvflg sngggkkskt 301 tkkvlqgnni llhslennkd mtlsnnfdhs vfninftdlf gvinasgspp drvlneinei 361 elkgwkcvgn lydnnkivvf qssnplledt kipqksftns krflislsal lasffayyry 421 rlsqrqeskk // LOCUS NP_015158 1504 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed DNA polymerase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015158 VERSION NP_015158.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183981.1 REFERENCE 1 (residues 1 to 1504) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1504) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1504) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1504) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1504) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11267. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1504 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1504 /product="DNA-directed DNA polymerase" /EC_number="2.7.7.7" /calculated_mol_wt="172827" Region 12..>221 /region_name="PTZ00166" /note="DNA polymerase delta catalytic subunit; Provisional" /db_xref="CDD:240301" Region 664..892 /region_name="DNA_polB_zeta_exo" /note="inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase; cd05778" /db_xref="CDD:99821" Region 919..1366 /region_name="POLBc_zeta" /note="DNA polymerase type-B zeta subfamily catalytic domain. DNA polymerase (Pol) zeta is a member of the eukaryotic B-family of DNA polymerases and distantly related to DNA Pol delta. Pol zeta plays a major role in translesion replication and the production...; cd05534" /db_xref="CDD:99917" Site order(975,978..980,1057,1086,1090,1144) /site_type="active" /db_xref="CDD:99917" Site order(1142,1144..1145) /site_type="metal-binding" /db_xref="CDD:99917" Region 1398..1479 /region_name="zf-C4pol" /note="C4-type zinc-finger of DNA polymerase delta; pfam14260" /db_xref="CDD:464119" CDS 1..1504 /gene="REV3" /locus_tag="YPL167C" /gene_synonym="PSO1" /coded_by="NM_001183981.1:1..4515" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:8658138]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16452144]" /experiment="EXISTENCE:direct assay:GO:0016035 zeta DNA polymerase complex [PMID:22711820|PMID:23066099|PMID:8658138]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:17248528|PMID:11313481]" /experiment="EXISTENCE:direct assay:GO:0070987 error-free translesion synthesis [PMID:12514101]" /experiment="EXISTENCE:genetic interaction:GO:0042276 error-prone translesion synthesis [PMID:9765213]" /note="Catalytic subunit of DNA polymerase zeta (pol zeta); involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair; may be involved in meiosis; forms a complex with Rev7p, Pol31p and Pol32p" /db_xref="GeneID:855936" /db_xref="SGD:S000006088" ORIGIN 1 msresndtiq sdtvrsssks dyfriqlnnq dyymskptfl dpshgeslpl nqfsqvpnir 61 vfgalptghq vlchvhgilp ymfikydgqi tdtstlrhqr caqvhktlev kirasfkrkk 121 ddkhdlagdk lgnlnfvadv svvkgipfyg yhvgwnlfyk isllnpscls riselirdgk 181 ifgkkfeiye shipyllqwt adfnlfgcsw invdrcyfrs pvlnsildid kltinddlql 241 lldrfcdfkc nvlsrrdfpr vgnglieidi lpqfiknrek lqhrdihhdf leklgdisdi 301 pvkpyvssar dmineltmqr eelslkeyke ppetkrhvsg hqwqssgefe afykkaqhkt 361 stfdgqipnf enfidknqkf saintpyeal pqlwprlpqi einnnsmqdk knddqvnasf 421 teyeicgvdn enegvkgsni ksrsyswlpe siaspkdsti lldhqtkyhn tinfsmdcam 481 tqnmaskrkl rssvsankts llsrkrkkvm aaglrygkra fvygeppfgy qdilnklede 541 gfpkidykdp ffsnpvdlen kpyayagkrf eissthvstr ipvqfggetv svynkptfdm 601 fsswkyalkp ptydavqkwy nkvpsmgnkk tesqismhtp hskflykfas dvsgkqkrkk 661 ssvhdslthl tleihantrs dkipdpaide vsmiiwclee etfpldldia yegimivhka 721 sedstfptki qhcineipvm fyesefemfe altdlvllld pdilsgfeih nfswgyiier 781 cqkihqfdiv relarvkcqi ktklsdtwgy ahssgimitg rhminiwral rsdvnltqyt 841 iesaafnilh krlphfsfes ltnmwnakks ttelktvlny wlsraqiniq llrkqdyiar 901 nieqarligi dfhsvyyrgs qfkvesflir icksesfill spgkkdvrkq kalecvplvm 961 epesafyksp livldfqsly psimigynyc ystmigrvre inltennlgv skfslprnil 1021 allkndvtia pngvvyakts vrkstlskml tdildvrvmi kktmneigdd nttlkrllnn 1081 kqlalkllan vtygytsasf sgrmpcsdla dsivqtgret lekaidiiek detwnakvvy 1141 gdtdslfvyl pgktaieafs ighamaervt qnnpkpiflk fekvyhpsil iskkryvgfs 1201 yespsqtlpi fdakgietvr rdgipaqqki iekcirllfq tkdlskikky lqneffkiqi 1261 gkvsaqdfcf akevklgayk sektapagav vvkrrinedh raepqykeri pylvvkgkqg 1321 qllrercvsp eeflegenle ldseyyinki lippldrlfn liginvgnwa qeivkskras 1381 ttttkvenit rvgtsatccn cgeeltkics lqlcddclek rstttlsfli kklkrqkeyq 1441 tlktvcrtcs yrytsdagie ndhiaskcns ydcpvfysrv kaerylrdnq svqreealis 1501 lndw // LOCUS NP_015159 213 aa linear PLN 30-JUN-2025 DEFINITION Atg29p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015159 VERSION NP_015159.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183980.1 REFERENCE 1 (residues 1 to 213) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 213) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 213) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 213) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 213) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11268. Method: conceptual translation. FEATURES Location/Qualifiers source 1..213 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..213 /product="Atg29p" /calculated_mol_wt="24577" Region 8..63 /region_name="ATG29_N" /note="Atg29 N-terminal domain; pfam18388" /db_xref="CDD:436458" CDS 1..213 /gene="ATG29" /locus_tag="YPL166W" /coded_by="NM_001183980.1:1..642" /experiment="EXISTENCE:direct assay:GO:0000045 autophagosome assembly [PMID:18725539]" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:16289106]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:18725539|PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0034497 protein localization to phagophore assembly site [PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:1990316 Atg1/ULK1 kinase complex [PMID:26753620]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:16289106]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /note="Autophagy-specific protein; required for recruiting other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:855937" /db_xref="SGD:S000006087" ORIGIN 1 mimnstntvv yikvkgrrpq gfldppkfew ngtkerqlwt mvsnlnysqd qidwqnlski 61 fetpefflkk rtyklfaehl ellqlqlekk rdlekysndq vnegmsdlih kytptlqndn 121 llnvsasplt terqdseeve tevtnealqh lqtskilnih kktsdsenkp ndkldkdgin 181 kemecgssdd dlssslsvsk saleealmdr lqf // LOCUS NP_015160 373 aa linear PLN 30-JUN-2025 DEFINITION Set6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015160 VERSION NP_015160.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183979.1 REFERENCE 1 (residues 1 to 373) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 373) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 373) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 373) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 373) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11269. Method: conceptual translation. FEATURES Location/Qualifiers source 1..373 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..373 /product="Set6p" /calculated_mol_wt="43619" Region <274..365 /region_name="SET_SMYD" /note="SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; cd20071" /db_xref="CDD:380997" Site order(274..275,290,300..304,337,339) /site_type="active" /db_xref="CDD:380997" Site order(274..275,290,300,336..337,339) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:380997" Site order(306,360,362,365) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:380997" CDS 1..373 /gene="SET6" /locus_tag="YPL165C" /coded_by="NM_001183979.1:1..1122" /note="SET domain hypothetical protein; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability" /db_xref="GeneID:855938" /db_xref="SGD:S000006086" ORIGIN 1 mtidgdvhei spffqvrqtk wggracfsng nipkgttvlq vsnftgtsis yefrkevchn 61 cfayanaktm kyklnydylr dlvcnahyqi npkkflgagl wfcsehcrts ylqipniiel 121 iecyeillhh fpsmlkryny tseqeeklns ilisenviqs swdeieskwi prinnmksak 181 rinqlpptce deyccirfvc eslfnlkymd pqcityrafn mlqsnelski skfpvllhfq 241 klvfqtlyil lpshlhrmls ipllrhilgt eygnafglwq egeasdsrey fgywvfpeas 301 yfnhscnpni tkyrkgnsml ftmnrdikkd eqicidysgv ldlptvkrra fladswffdc 361 acerckselq svh // LOCUS NP_015161 715 aa linear PLN 30-JUN-2025 DEFINITION mismatch repair protein MLH3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015161 VERSION NP_015161.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183978.1 REFERENCE 1 (residues 1 to 715) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 715) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 715) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 715) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 715) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11270. Method: conceptual translation. FEATURES Location/Qualifiers source 1..715 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..715 /product="mismatch repair protein MLH3" /calculated_mol_wt="81870" Region 12..213 /region_name="HATPase_MutL-MLH-PMS-like" /note="Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; cd16926" /db_xref="CDD:340403" Region 24..713 /region_name="mutL" /note="DNA mismatch repair endonuclease MutL; PRK00095" /db_xref="CDD:234630" Site order(31,35..36,38..39,57,59,61,63..64,72,77..80,97..100, 111,113,156..157,159) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:340403" Site order(73,100) /site_type="other" /note="ATP-lid" /db_xref="CDD:340403" CDS 1..715 /gene="MLH3" /locus_tag="YPL164C" /coded_by="NM_001183978.1:1..2148" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:23316435]" /experiment="EXISTENCE:mutant phenotype:GO:0006298 mismatch repair [PMID:9770499|PMID:10679328]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10570173]" /experiment="EXISTENCE:physical interaction:GO:0005634 nucleus [PMID:10570173]" /experiment="EXISTENCE:physical interaction:GO:0097587 MutLgamma complex [PMID:10570173|PMID:9770499]" /note="Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability" /db_xref="GeneID:855939" /db_xref="SGD:S000006085" ORIGIN 1 msqhirklds dvserlksqa ctvslasavr eivqnsvdah attidvmidl pnlsfavydd 61 gigltrsdln ilatqnytsk irkmndlvtm ktygyrgdal ysisnvsnlf vcskkkdyns 121 awmrkfpsks vmlsentilp idpfwkicpw srtksgtvvi vedmlynlpv rrrilkeepp 181 fktfntikad mlqilvmhpm islnvqytdk lrintevlfr sknitegltk hqqmsqvlrn 241 vfgaiippdm lkkvslkfne yqiegiiskm pvglkdlqfi yingrryads afqgyvdslf 301 qaqdfgekgm sllktksvgk pyrshpvfil dvrcpqtidd llqdpakkiv kpshirtiep 361 livktirsfl tfqgyltpdk sdssfeivnc sqktatlpds riqiskrnqv lnskmkiari 421 nsyigkpavn gcrinnstin yekiknirid gqksrlrnkl ssrpydsgft edydsigkti 481 tdfsisrsvl akyevinqvd kkfilircld qsihncpllv lvdqhacder irleelfysl 541 ltevvtgtfv ardlkdccie vdrteadlfk hyqsefkkwg igyetiegtm etslleiktl 601 pemltskyng dkdylkmvll qhahdlkdfk klpmdlshfe nytsvdklyw wkysscvptv 661 fheilnskac rsavmfgdel trqeciilis klsrchnpfe cahgrpsmvp iaelk // LOCUS NP_015162 260 aa linear PLN 30-JUN-2025 DEFINITION Svs1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015162 VERSION NP_015162.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183977.1 REFERENCE 1 (residues 1 to 260) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 260) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 260) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 260) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 260) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11271. Method: conceptual translation. FEATURES Location/Qualifiers source 1..260 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..260 /product="Svs1p" /calculated_mol_wt="27480" CDS 1..260 /gene="SVS1" /locus_tag="YPL163C" /coded_by="NM_001183977.1:1..783" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:11935221]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication" /db_xref="GeneID:855940" /db_xref="SGD:S000006084" ORIGIN 1 mifkilcsll lvtsnfasal yvnettsytp ytktltptys vspqettlty sdetttfyit 61 stfystywft tsqsaaiist ptastptast pslttstney tttysdtdtt ytstltstyi 121 itlstesane kaeqistsvt eiastvtesg stytstltst llvtvynsqa sntiatstag 181 daasnvdale klvsaehqsq miqttsadeq ycsastkyvt vtaaavtevv tttaepvvky 241 vtitadasnv tgsanngthi // LOCUS NP_015163 273 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL162C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015163 VERSION NP_015163.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183976.1 REFERENCE 1 (residues 1 to 273) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 273) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 273) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 273) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 273) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11272. Method: conceptual translation. FEATURES Location/Qualifiers source 1..273 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..273 /product="uncharacterized protein" /calculated_mol_wt="31216" Region 93..226 /region_name="STIMATE" /note="STIMATE family; pfam12400" /db_xref="CDD:463561" CDS 1..273 /locus_tag="YPL162C" /coded_by="NM_001183976.1:1..822" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology" /db_xref="GeneID:855941" /db_xref="SGD:S000006083" ORIGIN 1 myvsngkdtc qllgpvslfv qtlmgmtavi vllvkrnyeh prrkmivwsy digkqiigsl 61 gihflnlgis ilkkrrrslf aitakgndde dqcdwyflnl lldttvgipi lwlclyiiek 121 vlkslhfqni esgnyfpskt vgshprkplf safvkqllif ivglgvmkfc vflilnyled 181 laywfadlil gwsdswpnfq vflvmfvfpi llncfqyfcv dnvirlhses ltitnaenfe 241 tntflndeip dlsevsnevp nkdnnissyg sii // LOCUS NP_015164 633 aa linear PLN 30-JUN-2025 DEFINITION Bem4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015164 VERSION NP_015164.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183975.1 REFERENCE 1 (residues 1 to 633) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 633) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 633) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 633) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 633) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11273. Method: conceptual translation. FEATURES Location/Qualifiers source 1..633 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..633 /product="Bem4p" /calculated_mol_wt="70862" CDS 1..633 /gene="BEM4" /locus_tag="YPL161C" /gene_synonym="ROM7" /coded_by="NM_001183975.1:1..1902" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0007266 Rho protein signal transduction [PMID:8754839]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:8754839]" /note="Protein involved in establishment of cell polarity and bud emergence; regulates filamentous-growth mitogen-activated protein kinase (MAPK) pathway; interacts with the Rho1p small GTP-binding protein, the pleckstrin homology (PH) domain of Cdc24p, and with the Rho-type GTPase Cdc42p; stabilizes Cdc42p levels, resulting in elevated fMAPK pathway signaling; involved in maintenance of proper telomere length" /db_xref="GeneID:855942" /db_xref="SGD:S000006082" ORIGIN 1 mdyeeilfgl qpilnassik dvpmndvylg sylavmdqla vslrepsnrd ivgktgllln 61 lvrvleqald icfhdtsisi ndkiafyeis sevirciana iidnddnrei lldsggkkll 121 nyyiggvlql deissdksed slvdklqmrs vvllrnfcig nlkytenlap firgplfvll 181 kttqysylss pekvvlgsdl lndilkvnys nvqisdlffl sqyikkissn vqnkelqame 241 dgaveaysnt etqkfagqgn qeyiekeeed deedvncell lnlstcleti vakdetinft 301 neeqlvlsmq knlilslvcl esktfnnkli vmrrliscag nisanltnsn kreqslciet 361 ikssassyal aaalmilcns vasksdaval lklislseli qvgsllqdpl qyqgfldllr 421 kllnlentmw ldikdlftlf qimrrcheqt kyynnlrsll tnllnktltv lpsskihnsi 481 ssdptiisfi aehgtltsci amdkllvskk alpkeaitsl wdsifkfqnl gqaeqlsisd 541 lfhitktvgi ylkdssvtad vnpienilfk dyiqkltlil etilsfkenk dkgsescfnn 601 gkfiagiiln ivkntkcltp eeqnlealak sff // LOCUS NP_015165 1090 aa linear PLN 30-JUN-2025 DEFINITION leucine--tRNA ligase CDC60 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015165 VERSION NP_015165.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183974.1 REFERENCE 1 (residues 1 to 1090) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1090) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1090) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1090) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1090) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1090) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1090) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11274. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1090 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1090 /product="leucine--tRNA ligase CDC60" /EC_number="6.1.1.4" /calculated_mol_wt="124011" Region 17..1088 /region_name="leuS_arch" /note="leucyl-tRNA synthetase, archaeal and cytosolic family; TIGR00395" /db_xref="CDD:273056" Site 729..733 /site_type="other" /note="KMSKS motif" /db_xref="CDD:173906" CDS 1..1090 /gene="CDC60" /locus_tag="YPL160W" /coded_by="NM_001183974.1:1..3273" /experiment="EXISTENCE:direct assay:GO:0004823 leucine-tRNA ligase activity [PMID:9742237]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9742237]" /experiment="EXISTENCE:direct assay:GO:0006429 leucyl-tRNA aminoacylation [PMID:9742237]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:mutant phenotype:GO:1903432 regulation of TORC1 signaling [PMID:22424774]" /experiment="EXISTENCE:physical interaction:GO:1903432 regulation of TORC1 signaling [PMID:22424774]" /note="Cytosolic leucyl tRNA synthetase; ligates leucine to the appropriate tRNA; human homolog LARS can complement yeast temperature-sensitive mutant at restrictive temperature" /db_xref="GeneID:855943" /db_xref="SGD:S000006081" ORIGIN 1 mssglvlent arrdaliaie kkyqkiwaee hqfeidapsi edepitmdse elhrtypkfm 61 ssmaypymng vmhaghcftl skvefsigfe rmngkralfp lgfhctgmpi lacadklkre 121 aelfgknfdn vpaeeeeike etpaekdhed vtkfkakksk aaakkgrgky qfeimlqlgi 181 preeiikfad akywltyfpp lcesdctslg aridwrrsfv ttdanpyyda firwqmnklk 241 aagkikfger ytiysekdgq acmdhdrqsg egvtpqeyig vkiealefad daakiidsss 301 dldkskkfyf vaatlrpetm ygqtccfvsp tieygifdag dsyfittera fknmsyqklt 361 pkrgfykpiv tvpgkafigt kihapqsvyp elrilpmetv iatkgtgvvt cvpsnspddy 421 ittkdllhkp eyygikpewi dheivpimht ekygdltaka iveekkiqsp kdknllaeak 481 kiaykedyyt gtmiygpykg ekveqaknkv kadmiaagea fvynepesqv msrsgddciv 541 sledqwyvdy geeswkkqai eclegmqlfa pevknafegv ldwlknwavc rtyglgtrlp 601 wdekylvesl sdstiyqsfy tiahllfkdy ygneigplgi sadqmtdevf dyifqhqddv 661 kntniplpal qklrrefeyf ypldvsisgk dlipnhltff iythvalfpk kfwpkgiran 721 ghlmlnnskm skstgnfmtl eqtvekfgad aariafadag dtvedanfde snanaailrl 781 fnlkewaeei tkesnlrtge itdffdiafe hemnaliekt yeqyaltnyk nalkyglfdf 841 qaardyyrea sgvmhkdlia ryietqalll apiaphfaey iyrevlgnqt svqnakfpra 901 skpvdkgvla aldylrnlqr siregegqal kkkkgksaei daskpvkltl lisesfpewq 961 sqcveivrkl fseqtlddnk kvrehiepke mkrampfisl lkqrlanekp edvferelqf 1021 seidtvkaaa rnvkkaaqal kiaefsaisf pygaktgkdi ftgeeveipp vtkivenavp 1081 gnpgvvfqni // LOCUS NP_015166 253 aa linear PLN 30-JUN-2025 DEFINITION Pet20p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015166 VERSION NP_015166.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183973.1 REFERENCE 1 (residues 1 to 253) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 253) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 253) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 253) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11275. Method: conceptual translation. FEATURES Location/Qualifiers source 1..253 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..253 /product="Pet20p" /calculated_mol_wt="28972" Region 103..190 /region_name="Pet20" /note="Mitochondrial protein Pet20; pfam08692" /db_xref="CDD:400848" CDS 1..253 /gene="PET20" /locus_tag="YPL159C" /coded_by="NM_001183973.1:1..762" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16491469]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:16491469]" /note="Mitochondrial protein; required for respiratory growth under some conditions and for stability of the mitochondrial genome; subunit of a complex containing Mrx6p, Pim1p, and Mam33p that may regulate mtDNA replication" /db_xref="GeneID:855944" /db_xref="SGD:S000006080" ORIGIN 1 mlklarpfip plsrnnaiss givltsrrfq ssftflsnqs llsknqmksk rkkgskkaay 61 hrqppeheht aplikqnkti tkkehsdvrg shlkkkrsdf swlprvpsts hlkqsdmttn 121 vlysgyrplf inpndpklke dtgstlyefa mkledlnepl spwissatgl effsewenip 181 sellknlkpf hppkeksmnt nelihvsakr ntlvdnktse tlqrkmdefs krrgkgrkks 241 vvtllqmkkk leg // LOCUS NP_015167 758 aa linear PLN 30-JUN-2025 DEFINITION Aim44p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015167 VERSION NP_015167.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183972.1 REFERENCE 1 (residues 1 to 758) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 758) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 758) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 758) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 758) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11276. Method: conceptual translation. FEATURES Location/Qualifiers source 1..758 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..758 /product="Aim44p" /calculated_mol_wt="84715" CDS 1..758 /gene="AIM44" /locus_tag="YPL158C" /gene_synonym="GPS1" /coded_by="NM_001183972.1:1..2277" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:28148650]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:28148650|PMID:22842922|PMID:24451263|PMID:23468594|P MID:14562095]" /experiment="EXISTENCE:direct assay:GO:0032153 cell division site [PMID:25416945]" /experiment="EXISTENCE:direct assay:GO:0032174 cellular bud neck septin collar [PMID:30341817]" /experiment="EXISTENCE:direct assay:GO:0032177 cellular bud neck split septin rings [PMID:30341817]" /experiment="EXISTENCE:genetic interaction:GO:1990344 secondary cell septum biogenesis [PMID:23468594]" /experiment="EXISTENCE:mutant phenotype:GO:0005637 nuclear inner membrane [PMID:30341817]" /experiment="EXISTENCE:mutant phenotype:GO:0005886 plasma membrane [PMID:30341817]" /experiment="EXISTENCE:mutant phenotype:GO:0005935 cellular bud neck [PMID:23468594]" /experiment="EXISTENCE:mutant phenotype:GO:0045185 maintenance of protein location [PMID:23468594]" /experiment="EXISTENCE:mutant phenotype:GO:0098841 protein localization to cell division site after cytokinesis [PMID:25416945]" /experiment="EXISTENCE:mutant phenotype:GO:1901900 regulation of protein localization to cell division site [PMID:23468594]" /experiment="EXISTENCE:mutant phenotype:GO:1903473 positive regulation of mitotic actomyosin contractile ring contraction [PMID:24451263]" /experiment="EXISTENCE:mutant phenotype:GO:1990344 secondary cell septum biogenesis [PMID:23468594]" /note="Regulator of Cdc42p and Rho1p; regulates AMR closure through Hof1p; inhibits Cdc42-dependent Cla4 activation at the division site, to prevent budding in the old bud neck; recruits Nis1p and Nba1p to the division site with Nap1 and the Rax1p-Rax2p dependent inheritance of Nis1p and Nba1p to bud scars to prevent division site repolarization; keeps Rho1p at the division site after AMR contraction to control secondary septum formation; relocalizes from bud neck to cytoplasm upon replication stress" /db_xref="GeneID:855945" /db_xref="SGD:S000006079" ORIGIN 1 miirapirtk tksfrgdqmd fkfpsneslp rgtleeyhln nhhllndvfa aengvsrded 61 gnsqtlsdyt stsntntnsg yssngyysfa nisdnttssp rivinqneta rltssdsnks 121 dffashdfpg ndslhysssn vvknqlhsme aipegnitgs istafqtipt adnvsydiap 181 ssassllprk stsksailps tqeakpmtkl nmekdiktie lnnsvvpkpk kklnrvptir 241 rvessrfsns rysssvssks sssrcslkrs kairckggll yyftslgiki kkklrklrlv 301 lrrrlfsynv qkvpsatnsk ttkskaninn kskkrgtnlv nknsnstprq kksqryvsnl 361 qrsisskslv pvlapqkktk pltvdtkfka nhpqsedskv gsntprsplv sytpslrrtn 421 ssirraasil tasatmtpan nknsfisvpd nvshavtrns smysrsrlvr skpstalnai 481 arqpsivven kviplsmnry sikeedeyvi dtssmrelsp vnsvcssdyd ressesysny 541 adamettevd nkdrvecnne iqnvdannee tsneesynlm khylstviaq rimlrvqiar 601 iqnyksnvvy mnksaetnst iyedlvdsll teyeadgsss qifdgvtvra deeeeededd 661 eddeeeeeen ddeedeedee ddeddeeeee krkegegrnl akevdelael spmrkqsdls 721 itlrspfaml npaysnsiis lptgvvkrsl tlpvgmki // LOCUS NP_015168 315 aa linear PLN 30-JUN-2025 DEFINITION RNA methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015168 VERSION NP_015168.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183971.1 REFERENCE 1 (residues 1 to 315) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 315) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 315) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 315) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11277. Method: conceptual translation. FEATURES Location/Qualifiers source 1..315 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..315 /product="RNA methyltransferase" /calculated_mol_wt="36396" Region 98..262 /region_name="Methyltransf_15" /note="RNA cap guanine-N2 methyltransferase; pfam09445" /db_xref="CDD:370496" Site order(104..110,126..127,153..155,175) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..315 /gene="TGS1" /locus_tag="YPL157W" /coded_by="NM_001183971.1:1..948" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11983179]" /experiment="EXISTENCE:mutant phenotype:GO:0001510 RNA methylation [PMID:11983179]" /experiment="EXISTENCE:mutant phenotype:GO:0008033 tRNA processing [PMID:27348091]" /experiment="EXISTENCE:mutant phenotype:GO:0008173 RNA methyltransferase activity [PMID:11983179]" /experiment="EXISTENCE:mutant phenotype:GO:0017126 nucleologenesis [PMID:15340060]" /experiment="EXISTENCE:mutant phenotype:GO:0032210 regulation of telomere maintenance via telomerase [PMID:18840651|PMID:18273059]" /experiment="EXISTENCE:mutant phenotype:GO:0036261 7-methylguanosine cap hypermethylation [PMID:11983179]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:21398639]" /note="Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p" /db_xref="GeneID:855946" /db_xref="SGD:S000006078" ORIGIN 1 mgrtfihask ikhaarkrkh hsnfrtlikl lnndaykies skplkngklf kywknrrrlf 61 skidsasiym tdelwfsvtp eriacflanf vkacmpnaer ildvfcgggg ntiqfamqfp 121 yvygvdysie hiyctaknaq sygvddriwl krgswkklvs kqklskikyd cvfgsppwgg 181 peylrndvyd leqhlkpmgi tkmlksflkl spnvimflpr nsdlnqlsra trkvlgpfak 241 ckvlyvkeng ymkgifcmwg ecffnyepas tensrresse keelssenee lskrkkhest 301 tttkdntvdi ydvng // LOCUS NP_015169 284 aa linear PLN 30-JUN-2025 DEFINITION pheromone-regulated protein PRM4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015169 VERSION NP_015169.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183970.1 REFERENCE 1 (residues 1 to 284) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 284) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 284) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 284) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 284) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11278. Method: conceptual translation. FEATURES Location/Qualifiers source 1..284 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..284 /product="pheromone-regulated protein PRM4" /calculated_mol_wt="31881" CDS 1..284 /gene="PRM4" /locus_tag="YPL156C" /coded_by="NM_001183970.1:1..855" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /note="Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift" /db_xref="GeneID:855947" /db_xref="SGD:S000006077" ORIGIN 1 miadssvlkk htaikrstri isltlvllgv fsfllltwnd slefynsadp senkknseee 61 sekkfvyklp nllktadsfl snenelnfqk vkeeisniqs evevdipeps skatskfssr 121 sfqtdnvvta tttttlnprs sslalqkncd hkkfdprtdf ldiirtspav lfikssqads 181 iflknllqre feispelatv dlekhshgye lekyikqnkl nidtsaales iqspylflng 241 isvinrgmvr diiephskgl llpllksear gnllvekkdi psns // LOCUS NP_015170 706 aa linear PLN 30-JUN-2025 DEFINITION Kip2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015170 VERSION NP_015170.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183969.1 REFERENCE 1 (residues 1 to 706) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 706) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 706) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 706) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 706) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11279. Method: conceptual translation. FEATURES Location/Qualifiers source 1..706 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..706 /product="Kip2p" /calculated_mol_wt="78247" Region 102..493 /region_name="KISc_CENP_E" /note="Kinesin motor domain, CENP-E/KIP2-like subgroup; cd01374" /db_xref="CDD:276825" Site order(110,202,205,207..210,371) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:276825" Region <445..>698 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Site order(446,449,452) /site_type="other" /note="microtubule interaction site [polypeptide binding]" /db_xref="CDD:276825" CDS 1..706 /gene="KIP2" /locus_tag="YPL155C" /coded_by="NM_001183969.1:1..2121" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:31490122]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:9693366]" /experiment="EXISTENCE:direct assay:GO:0007018 microtubule-based movement [PMID:31490122]" /experiment="EXISTENCE:direct assay:GO:0007026 negative regulation of microtubule depolymerization [PMID:26576948]" /experiment="EXISTENCE:direct assay:GO:0015631 tubulin binding [PMID:37093124]" /experiment="EXISTENCE:direct assay:GO:0046785 microtubule polymerization [PMID:37093124|PMID:26576948]" /experiment="EXISTENCE:direct assay:GO:0061863 microtubule plus end polymerase [PMID:26576948|PMID:37093124]" /experiment="EXISTENCE:direct assay:GO:1903754 cortical microtubule plus-end [PMID:15177030|PMID:18411245]" /experiment="EXISTENCE:genetic interaction:GO:0008574 plus-end-directed microtubule motor activity [PMID:15177030|PMID:18411245]" /experiment="EXISTENCE:mutant phenotype:GO:0007026 negative regulation of microtubule depolymerization [PMID:37093124|PMID:9693366]" /experiment="EXISTENCE:mutant phenotype:GO:0008574 plus-end-directed microtubule motor activity [PMID:15177030]" /experiment="EXISTENCE:mutant phenotype:GO:0015631 tubulin binding [PMID:37093124]" /experiment="EXISTENCE:mutant phenotype:GO:0030473 nuclear migration along microtubule [PMID:9693366]" /experiment="EXISTENCE:mutant phenotype:GO:0046785 microtubule polymerization [PMID:37093124]" /experiment="EXISTENCE:mutant phenotype:GO:0061863 microtubule plus end polymerase [PMID:37093124]" /note="Kinesin-related motor protein and plus-end directed microtubule (MT) polymerase; involved in mitotic spindle positioning, nuclear migration, microtubule polymerization and inhibition of MT catastrophe; stabilizes microtubules by targeting Bik1p to the MT plus end; Kip2p levels are controlled during the cell cycle" /db_xref="GeneID:855948" /db_xref="SGD:S000006076" ORIGIN 1 miqkmspslr rpstrsssgs snipqspsvr stssfsnltr nsirstsnsg sqsisasstr 61 snsplrsvsa ksdpflhpgr irirrsdsin nnsrkndtyt gsitvtirpk prsvgtsrdh 121 vglksprysq prsnshhgsn tfvrdpwfit ndktivheei gefkfdhvfa shctnlevye 181 rtskpmidkl lmgfnatifa ygmtgsgktf tmsgneqelg liplsvsylf tnimeqsmng 241 dkkfdviisy leiyneriyd llesgleesg sristpsrly msksnsnglg velkirddsq 301 ygvkviglte rrcesseell rwiavgdksr kigetdynar ssrshaivli rltstnvkng 361 tsrsstlslc dlagseratg qqerrkegsf inksllalgt visklsadkm nsvgsnipsp 421 sasgsssssg natnngtsps nhipyrdskl trllqpalsg dsivttictv dtrndaaaet 481 mntlrfasra knvalhvskk siisngnndg dkdrtiellr rqleeqrrmi selknrsnig 541 epltkssnes tykdikatgn dgdpnlalmr aenrvlkykl enceklldkd vvdlqdseim 601 eivemlpfev gtlletkfqg lesqirqyrk ytqkledkim aleksghtam sltgcdgtev 661 ielqkmlerk dkmiealqsa krlrdralkp lintqqsphp vvdndk // LOCUS NP_015171 405 aa linear PLN 30-JUN-2025 DEFINITION proteinase A [Saccharomyces cerevisiae S288C]. ACCESSION NP_015171 VERSION NP_015171.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183968.1 REFERENCE 1 (residues 1 to 405) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 405) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 405) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 405) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11280. Method: conceptual translation. FEATURES Location/Qualifiers source 1..405 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..405 /product="proteinase A" /EC_number="3.4.23.25" /calculated_mol_wt="44368" Region 81..403 /region_name="Proteinase_A_fungi" /note="Fungal Proteinase A, aspartic proteinase superfamily; cd05488" /db_xref="CDD:133155" Site order(86,109,152,154,187..188,266,269,297,323,358,360,370) /site_type="active" /note="inhibitor binding pocket [active]" /db_xref="CDD:133155" Site order(109..112,294..297) /site_type="active" /note="catalytic motif [active]" /db_xref="CDD:133155" Site order(109,294) /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:133155" Site 149..159 /site_type="active" /note="Active site flap [active]" /db_xref="CDD:133155" CDS 1..405 /gene="PEP4" /locus_tag="YPL154C" /gene_synonym="PHO9; PRA1; yscA" /coded_by="NM_001183968.1:1..1218" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:23708375|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008233 peptidase activity [PMID:7002931]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:31332264]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:23382696]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:29514932]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:12529432]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0051603 proteolysis involved in protein catabolic process [PMID:16183335]" /note="Vacuolar aspartyl protease (proteinase A); required for post-translational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; plays a protective role in acetic acid induced apoptosis; synthesized as a zymogen, self-activates; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway" /db_xref="GeneID:855949" /db_xref="SGD:S000006075" ORIGIN 1 mfslkallpl alllvsanqv aakvhkakiy khelsdemke vtfeqhlahl gqkyltqfek 61 anpevvfsre hpfftegghd vpltnylnaq yytditlgtp pqnfkvildt gssnlwvpsn 121 ecgslacflh skydheasss ykangtefai qygtgslegy isqdtlsigd ltipkqdfae 181 atsepgltfa fgkfdgilgl gydtisvdkv vppfynaiqq dlldekrfaf ylgdtskdte 241 nggeatfggi deskfkgdit wlpvrrkayw evkfegiglg deyaeleshg aaidtgtsli 301 tlpsglaemi naeigakkgw tgqytldcnt rdnlpdlifn fngynftigp ydytlevsgs 361 cisaitpmdf pepvgplaiv gdaflrkyys iydlgnnavg lakai // LOCUS NP_015172 821 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine/tyrosine protein kinase RAD53 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015172 VERSION NP_015172.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183967.1 REFERENCE 1 (residues 1 to 821) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 821) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 821) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 821) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 821) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 821) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 821) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11281. Method: conceptual translation. FEATURES Location/Qualifiers source 1..821 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..821 /product="serine/threonine/tyrosine protein kinase RAD53" /EC_number="2.7.12.1" /calculated_mol_wt="91832" Region 35..148 /region_name="FHA_RAD53-like_rpt1" /note="first forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; cd22689" /db_xref="CDD:438741" Site order(70..72,80,82..86,106..107) /site_type="other" /note="phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438741" Region 196..465 /region_name="STKc_Rad53_Cds1" /note="Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; cd14098" /db_xref="CDD:271000" Site order(204..208,212,225,227,257,273..276,280,282,318..319, 321,323..324,326,338..339,342,356..360,362) /site_type="active" /db_xref="CDD:271000" Site order(204..207,212,225,227,257,273..276,280,323..324,326, 338..339) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:271000" Site order(208,280,282,318..319,321,323,342,356..360,362) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:271000" Site order(338..347,349..360) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:271000" Region 577..695 /region_name="FHA_RAD53-like_rpt2" /note="second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; cd22690" /db_xref="CDD:438742" Site order(604..605,617,619..620,622,653,655..656) /site_type="other" /note="putative phosphopeptide binding site [polypeptide binding]" /db_xref="CDD:438742" CDS 1..821 /gene="RAD53" /locus_tag="YPL153C" /gene_synonym="LSD1; MEC2; SPK1" /coded_by="NM_001183967.1:1..2466" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16816422]" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004712 protein serine/threonine/tyrosine kinase activity [PMID:8355715|PMID:30377154]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:8355715]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:genetic interaction:GO:0000077 DNA damage checkpoint signaling [PMID:7926756]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16816422]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:8355715]" /experiment="EXISTENCE:mutant phenotype:GO:0008104 intracellular protein localization [PMID:18045534]" /experiment="EXISTENCE:mutant phenotype:GO:0009202 deoxyribonucleoside triphosphate biosynthetic process [PMID:17188244]" /experiment="EXISTENCE:mutant phenotype:GO:0042326 negative regulation of phosphorylation [PMID:24130507]" /experiment="EXISTENCE:mutant phenotype:GO:0043247 telomere maintenance in response to DNA damage [PMID:24130507]" /note="DNA damage response kinase; signal transduction pathway component required for DNA damage and replication checkpoints, promoting cell cycle arrest and DNA repair; role in initiation of DNA replication; inhibits gene gating through NPC protein phosphorylation, to promote fork stability; activates downstream kinase Dun1p; senses mtDNA depletion and mitochondrial ROS; relocalizes to cytosol under hypoxia; contains two FHA domains; human homolog CHEK2 implicated in breast cancer complements the null" /db_xref="GeneID:855950" /db_xref="SGD:S000006074" ORIGIN 1 menitqptqq stqatqrfli ekfsqeqige nivcrvictt gqipirdlsa disqvlkekr 61 sikkvwtfgr npacdyhlgn isrlsnkhfq illgedgnll lndistngtw lngqkvekns 121 nqllsqgdei tvgvgvesdi lslvifindk fkqcleqnkv drirsnlknt skiaspglts 181 stassmvank tgifkdfsii devvgqgafa tvkkaiertt gktfavkiis krkvignmdg 241 vtrelevlqk lnhprivrlk gfyedtesyy mvmefvsggd lmdfvaahga vgedagreis 301 rqiltaikyi hsmgishrdl kpdnilieqd dpvlvkitdf glakvqgngs fmktfcgtla 361 yvapevirgk dtsvspdeye erneysslvd mwsmgclvyv iltghlpfsg stqdqlykqi 421 grgsyhegpl kdfriseear dfidsllqvd pnnrstaaka lnhpwikmsp lgsqsygdfs 481 qislsqslsq qkllenmdda qyefvkaqrk lqmeqqlqeq dqedqdgkiq gfkipahapi 541 rytqpksiea etreqkllhs nntenvkssk kkgngrfltl kplpdsiiqe sleiqqgvnp 601 ffigrsedcn ckiednrlsr vhcfifkkrh avgksmyesp aqglddiwyc htgtnvsyln 661 nnrmiqgtkf llqdgdeiki iwdknnkfvi gfkveindtt glfneglgml qeqrvvlkqt 721 aeekdlvkkl tqmmaaqran qpsassssms akkppvsdtn nngnnsvlnd lvespinant 781 gnilkrihsv slsqsqidps kkvkrakldq tskgpenlqf s // LOCUS NP_878180 32 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL152W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878180 VERSION NP_878180.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184627.1 REFERENCE 1 (residues 1 to 32) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 32) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 32) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 32) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 32) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 32) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 32) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11282. Method: conceptual translation. FEATURES Location/Qualifiers source 1..32 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..32 /product="uncharacterized protein" /calculated_mol_wt="3706" CDS 1..32 /locus_tag="YPL152W-A" /coded_by="NM_001184627.1:1..99" /note="hypothetical protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466519" /db_xref="SGD:S000028721" ORIGIN 1 mmvhltlksh likeellwha lspsyscryh gr // LOCUS NP_015173 358 aa linear PLN 30-JUN-2025 DEFINITION peptidylprolyl isomerase RRD2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015173 VERSION NP_015173.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183966.1 REFERENCE 1 (residues 1 to 358) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 358) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 358) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 358) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 358) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11283. Method: conceptual translation. FEATURES Location/Qualifiers source 1..358 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..358 /product="peptidylprolyl isomerase RRD2" /EC_number="5.2.1.8" /calculated_mol_wt="41321" Region 1..358 /region_name="LAG1" /note="Phosphotyrosyl phosphatase activator [Cell division and chromosome partitioning / Signal transduction mechanisms]; COG5057" /db_xref="CDD:227390" Site order(72,82,128,181..182,184,187..188,190,196,244,247..248, 252,289) /site_type="other" /note="peptide-induced dimer interface [polypeptide binding]" /db_xref="CDD:239754" Site order(128,130,132..135,184..185,194..196,198,260,263,269, 273,276,280,284,286..287,289..290) /site_type="active" /note="putative interaction site [active]" /db_xref="CDD:239754" Site order(128,130,132..135,185..187,286..287,289..290) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:239754" Site order(190..191,255..256,259..260,263,272..273,283..286) /site_type="active" /note="peptide binding pocket [active]" /db_xref="CDD:239754" Site order(190,252,263,272,276,284) /site_type="other" /note="putative PP2A binding surface [polypeptide binding]" /db_xref="CDD:239754" CDS 1..358 /gene="RRD2" /locus_tag="YPL152W" /gene_synonym="YPA2" /coded_by="NM_001183966.1:1..1077" /experiment="EXISTENCE:direct assay:GO:0000159 protein phosphatase type 2A complex [PMID:17550305]" /experiment="EXISTENCE:direct assay:GO:0003755 peptidyl-prolyl cis-trans isomerase activity [PMID:16380387]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:10660069]" /experiment="EXISTENCE:mutant phenotype:GO:0007052 mitotic spindle organization [PMID:11262194]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:12952889]" /note="Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855951" /db_xref="SGD:S000006073" ORIGIN 1 mlpekrlltp ddmklweesp trahftkfii dlaesvkghe nsqykepise sinsmmnlls 61 qikditqkhp vikdadssrf gkvefrdfyd evsrnsrkil rsefpsltde qleqlsiyld 121 eswgnkrrid ygsghelnfm cllyglysyg ifnlsndstn lvlkvfieyl kimriletky 181 wlepagshgv wglddyhflp flfgafqltt hkhlkpisih nnelvemfah rylyfgciaf 241 inkvkssasl rwhspmlddi sgvktwskva egmikmykae vlsklpimqh fyfseflpcp 301 dgvspprghi hdgtdkddec nfeghvhttw gdccgiklps aiaatemnkk hhkpipfd // LOCUS NP_015174 451 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein PRP46 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015174 VERSION NP_015174.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183965.1 REFERENCE 1 (residues 1 to 451) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 451) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 451) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 451) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 451) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11284. Method: conceptual translation. FEATURES Location/Qualifiers source 1..451 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..451 /product="mRNA splicing protein PRP46" /calculated_mol_wt="50569" Region 131..427 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Site order(138,157,161,167..168,180..181,199,203,209..210, 222..223,240,245,251..252,265,282,287,293..294,306..307, 325,329,334..335,347,349,366,370,376..377,398,416,420, 426..427) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 144..180 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 186..222 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 227..263 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 270..305 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 311..346 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 352..392 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 399..426 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..451 /gene="PRP46" /locus_tag="YPL151C" /gene_synonym="NTC50" /coded_by="NM_001183965.1:1..1356" /experiment="EXISTENCE:direct assay:GO:0005681 spliceosomal complex [PMID:11884590]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:12554883]" /experiment="EXISTENCE:physical interaction:GO:0000974 Prp19 complex [PMID:12088152]" /note="Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs" /db_xref="GeneID:855952" /db_xref="SGD:S000006072" ORIGIN 1 mdgndhkven lgdvdkfysr irwnnqfsym atlpphlqse megqksllmr ydtyrkesss 61 fsgegkkvtl qhvptdfsea sqaviskkdh dthasafvnk ifqpevaeel ivnryeklls 121 qrpewhapwk lsrvinghlg wvrcvaidpv dnewfitgsn dttmkvwdla tgklkttlag 181 hvmtvrdvav sdrhpylfsv sedktvkcwd leknqiirdy yghlsgvrtv sihptldlia 241 tagrdsvikl wdmrtripvi tlvghkgpin qvqctpvdpq vvssstdatv rlwdvvagkt 301 mkvlthhkrs vratalhpke fsvasactdd irswglaegs lltnfesekt giintlsinq 361 ddvlfaggdn gvlsfydyks ghkyqslatr emvgsleger svlcstfdkt glrlitgead 421 ksikiwkqde tatkesepgl awnpnlsakr f // LOCUS NP_015175 901 aa linear PLN 30-JUN-2025 DEFINITION non-specific serine/threonine protein kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015175 VERSION NP_015175.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183964.1 REFERENCE 1 (residues 1 to 901) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 901) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 901) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 901) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 901) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11285. Method: conceptual translation. FEATURES Location/Qualifiers source 1..901 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..901 /product="non-specific serine/threonine protein kinase" /EC_number="2.7.11.1" /calculated_mol_wt="100515" Region 40..286 /region_name="STKc_AMPK-like" /note="Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; cd14003" /db_xref="CDD:270905" Site order(47..51,55,68,70,95,111..114,118,120..121,123, 156..157,159,161..162,164,174..175,178,192..196,198, 228..231) /site_type="active" /db_xref="CDD:270905" Site order(47..50,55,68,70,95,111..114,118,161..162,164, 174..175) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270905" Site order(118,120..121,123,157,159,161,178,192..196,198, 228..231) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270905" Site order(174..185,189..196) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270905" CDS 1..901 /locus_tag="YPL150W" /coded_by="NM_001183964.1:1..2706" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0006468 protein phosphorylation [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0036464 cytoplasmic ribonucleoprotein granule [PMID:25342717]" /note="Protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study" /db_xref="GeneID:855953" /db_xref="SGD:S000006071" ORIGIN 1 mvnpvgsskl eqnniksiig ssynrlysqf tsdeltevgn ykilkqigeg sfgkvylalh 61 rpthrkvclk tsdkndpniv revfyhrqfd fpyitklyev ivteskvwma leycpgkely 121 dhllslrris llecgelfaq isgavyyahs mhcvhrdlkl enilldkngn akltdfgftr 181 ecmtkttlet vcgttvymap elierrtydg fkidiwslgv ilytlitgyl pfddddeakt 241 kwkivneepk ydakvipdda rdlisrllak npgerpslsq vlrhpflqpy gsvvldqtqk 301 ilcrqrsggt qfksklerrl lkrlkqsgvd tqaikqsilk kkcdslsglw llllaqgkkq 361 enckypkrsr svlsvkkvie sathndtngi sedvlkpsle lsraaslskm lnkgsdfvts 421 mtpvsrkksk dsakvlnptl skissqrays hsiagsprks nnflqkvssf fkskkssnsn 481 snnsihtnvs esliasnrga pssgsflkkn sgsiqksrtd tvanpsrtes igslnenvag 541 aivprsannt tlenkktsgn eiglkvapel llnehiriee prlkrfkssi sseisqtstg 601 nydsesaens rsisfdgkvs pppirnrpls eisqisndty iseystdgnn ssfkisdtik 661 psyirkgset tsqysassek mtngygrkfv rrdlsivsta sstserssrt dsfydittat 721 pvvttdnrrn knnnlkesvl prfgtqrpwt gkrtyttsrh gknarrsskr glfkitssnt 781 dsiiqevsss eeedhnviys kgkglptpvl qtkgliengl nerdeegdde yaihtdgefs 841 ikpqfsddvi dkqnhlpsvk avatkrslse gsnwsssyld sdnnrrrvss llvedggnpt 901 a // LOCUS NP_015176 294 aa linear PLN 30-JUN-2025 DEFINITION Atg5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015176 VERSION NP_015176.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183963.1 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11286. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..294 /product="Atg5p" /calculated_mol_wt="33429" Region 83..282 /region_name="APG5" /note="Autophagy protein Apg5; pfam04106" /db_xref="CDD:461175" CDS 1..294 /gene="ATG5" /locus_tag="YPL149W" /gene_synonym="APG5" /coded_by="NM_001183963.1:1..885" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:18497569|PMID:11689437]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005776 autophagosome [PMID:15155809]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:11897782]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:23503366]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:23064152]" /experiment="EXISTENCE:direct assay:GO:0019776 Atg8-family ligase activity [PMID:17986448]" /experiment="EXISTENCE:direct assay:GO:0034274 Atg12-Atg5-Atg16 complex [PMID:11897782]" /experiment="EXISTENCE:direct assay:GO:0061908 phagophore [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:0140355 cargo receptor ligand activity [PMID:27879200]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:32788210|PMID:8921905]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:10712513]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0051365 cellular response to potassium ion starvation [PMID:32788210]" /note="Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; Atg5p-Atg12p conjugate enhances E2 activity of Atg3 by rearranging its catalytic site, also forms a complex with Atg16p; the Atg5-Atg12/Atg16 complex binds to membranes and is essential for autophagosome formation; also involved in methionine restriction extension of chronological lifespan in an autophagy-dependent manner" /db_xref="GeneID:855954" /db_xref="SGD:S000006070" ORIGIN 1 mndikqllwn gelnvlvsid psflmkgspr eiavlrirvp retylvnymp liwnkiksfl 61 sfdpltdsek yfwfehnktp ipwnypvgvl fdclagksat fttsfenqvk dvltflrihl 121 vmgdslppti ipiassktqa ekfwfhqwkq vcfilngssk aimslsvnea rkfwgsvitr 181 nfqdfieisn kisssrprhi pliiqtsrts gtfrisqpti smtgvnptlk diegdildvk 241 egingndvmv icqgieipwh mllydlyskl rsfdgflyit lvpikggdka ssel // LOCUS NP_015177 173 aa linear PLN 30-JUN-2025 DEFINITION holo-[acyl-carrier-protein] synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015177 VERSION NP_015177.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183962.1 REFERENCE 1 (residues 1 to 173) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 173) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 173) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 173) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11287. On Oct 2, 2003 this sequence version replaced NP_015177.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..173 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..173 /product="holo-[acyl-carrier-protein] synthase" /EC_number="2.7.8.7" /calculated_mol_wt="19842" Region 14..166 /region_name="AcpS" /note="Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid transport and metabolism]; COG0736" /db_xref="CDD:440499" CDS 1..173 /gene="PPT2" /locus_tag="YPL148C" /coded_by="NM_001183962.1:1..522" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0008897 holo-[acyl-carrier-protein] synthase activity [PMID:9712852]" /experiment="EXISTENCE:direct assay:GO:0031108 holo-[acyl-carrier-protein] biosynthetic process [PMID:9712852]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:9712852]" /note="Phosphopantetheine:protein transferase (PPTase); activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation" /db_xref="GeneID:855955" /db_xref="SGD:S000006069" ORIGIN 1 msfasrnigr kiagvgvdiv ylprfahile kyspfdpcgr stlnkitrkf mhekerfhfs 61 nllieenclt prlheyiagv walkecslka lcccvskhdl ppaqvlyagm lyktqtdtgv 121 pqlefdkmfg kkypkyqqls knydslfsth eflvslshdk dyliavtnlv ere // LOCUS NP_015178 870 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette long-chain fatty acid transporter PXA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015178 VERSION NP_015178.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183961.1 REFERENCE 1 (residues 1 to 870) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 870) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 870) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 870) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 870) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 870) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 870) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11288. Method: conceptual translation. FEATURES Location/Qualifiers source 1..870 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..870 /product="ATP-binding cassette long-chain fatty acid transporter PXA1" /calculated_mol_wt="99895" Region 113..827 /region_name="3a01203" /note="Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein; TIGR00954" /db_xref="CDD:273360" CDS 1..870 /gene="PXA1" /locus_tag="YPL147W" /gene_synonym="LPI1; PAL1; PAT2; SSH2" /coded_by="NM_001183961.1:1..2613" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:35127709|PMID:8670886]" /experiment="EXISTENCE:direct assay:GO:0015867 ATP transport [PMID:35127709]" /experiment="EXISTENCE:direct assay:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:35127709]" /experiment="EXISTENCE:mutant phenotype:GO:0015908 fatty acid transport [PMID:8670886]" /experiment="EXISTENCE:mutant phenotype:GO:0042626 ATPase-coupled transmembrane transporter activity [PMID:8670886]" /note="Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p; required for import of long-chain fatty acids into peroxisomes; similar to human adrenoleukodystrophy transporters ABCD1and ABCD2, and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder; human ABCD1 and ABCD2 can each partially complement yeast pxa1 pxa2 double null mutant" /db_xref="GeneID:855956" /db_xref="SGD:S000006068" ORIGIN 1 msttlaapak lkslllnlht hciglhvndv tpkvyfklli rhllqisrsn aahpklrrra 61 qillvslfls gvtlfsgvty stfkiilkcy kfykfpwkrr nrrplirrtr sqmqldsgar 121 imyipevelv drqspddnkf mnatdkkkrk rifippkdnd vyehdkflfk nvelerakns 181 qlfyskflnq mnvlskilip tvfdknflll taqifflvmr twlslfvakl dgqivkniia 241 grgrsflwdl gcwfliavpa sytnsaikll qrklslnfrv nltryihdmy ldkrltfykl 301 ifdakasnsv iknidnsitn dvakfcdatc svfaniakpv idliffsvyl rdnlgtvgva 361 gifvnyfitg filrkytppl gklagersas dgdyynyhln minnseeiaf yqgtavertk 421 vkelydvlme kmllvdkvkf gynmledyvl kytwsglgyv fasipivmst latginseek 481 nmkefivnkr lmlsladags rlmhsikdis qltgytnrif tllsvlhrvh slnfnygavp 541 silsirteda srnsnllptt dnsqdairgt iqrnfngirl enidviipsv rasegiklin 601 kltfqiplhi dpitsksnsi qdlskandik lpflqgsgss llilgpngcg kssiqriiae 661 iwpvynkngl lsipsennif fipqkpyfsr ggtlrdqiiy pmssdeffdr gfrdkelvqi 721 lvevkldyll krgvgltyld aiadwkdlls ggekqrvnfa rimfhkplyv vldeatnais 781 vdmedylfnl lkryrfnfis isqrptliky hemlleigen rdgkwqlqav gtdeaitsid 841 neieelerkl ervkgweder tklrekleii // LOCUS NP_015179 455 aa linear PLN 30-JUN-2025 DEFINITION Nop53p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015179 VERSION NP_015179.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183960.1 REFERENCE 1 (residues 1 to 455) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 455) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 455) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 455) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 455) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11289. Method: conceptual translation. FEATURES Location/Qualifiers source 1..455 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..455 /product="Nop53p" /calculated_mol_wt="52425" Region 17..423 /region_name="Nop53" /note="Nop53 (60S ribosomal biogenesis); pfam07767" /db_xref="CDD:462259" CDS 1..455 /gene="NOP53" /locus_tag="YPL146C" /coded_by="NM_001183960.1:1..1368" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16043506|PMID:11914276|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:10684247|PMID:16043506]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:16128814]" /experiment="EXISTENCE:mutant phenotype:GO:0000055 ribosomal large subunit export from nucleus [PMID:16043506]" /experiment="EXISTENCE:mutant phenotype:GO:0000176 nuclear exosome (RNase complex) [PMID:31662437]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15686447]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:16128814]" /note="Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p and with the nucleolar proteins Nop17p and Nip7p; null mutant is viable but growth is severely impaired" /db_xref="GeneID:855957" /db_xref="SGD:S000006067" ORIGIN 1 maptnltkkp sqykqssrkg kkawrknidl sdveqymekk idheithgts ditslqndal 61 fhvdvegdei lknklikrkq ikkvlkskei ldavktnski aalnhhknss gnpnkiqgvs 121 khelkklmal agrvhgeski knrvakdglv kttagdlwge esnskkqkvk lpsgikldve 181 kkdqipeell kksttswsta svrpstldie piavkeftei phagksynpn nkawselink 241 eykeekared erialekyke rirhlmetld dneeeesssn eeeeeeeeen enenestqcs 301 gsdkeiklsi nkpvknkkkt kyqrnkakrh eekvklqqel kelrqrvkdl eevinseete 361 ilsaiesdsn kvkkskknkk hklgtkysvi derleikfsd elsdslrklk pegnllydtv 421 rklqssgkve trvpvrkgrk ykqkitekwt hkdfk // LOCUS NP_015180 434 aa linear PLN 30-JUN-2025 DEFINITION oxysterol-binding protein KES1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015180 VERSION NP_015180.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183959.1 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11290. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..434 /product="oxysterol-binding protein KES1" /calculated_mol_wt="49361" Region 12..363 /region_name="Oxysterol_BP" /note="Oxysterol-binding protein; pfam01237" /db_xref="CDD:460126" CDS 1..434 /gene="KES1" /locus_tag="YPL145C" /gene_synonym="BSR3; LPI3; OSH4" /coded_by="NM_001183959.1:1..1305" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:11916983]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:8978672|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:16585271|PMID:20008566]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:20729555]" /experiment="EXISTENCE:direct assay:GO:0070300 phosphatidic acid binding [PMID:20729555]" /experiment="EXISTENCE:direct assay:GO:0120015 sterol transfer activity [PMID:20008566]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0006892 post-Golgi vesicle-mediated transport [PMID:8978672|PMID:11916983]" /experiment="EXISTENCE:genetic interaction:GO:0006897 endocytosis [PMID:15173322]" /experiment="EXISTENCE:genetic interaction:GO:0015918 sterol transport [PMID:16585271]" /experiment="EXISTENCE:genetic interaction:GO:0030011 maintenance of cell polarity [PMID:17004323]" /experiment="EXISTENCE:genetic interaction:GO:0034727 piecemeal microautophagy of the nucleus [PMID:15367582]" /experiment="EXISTENCE:mutant phenotype:GO:0005546 phosphatidylinositol-4,5-bisphosphate binding [PMID:11916983]" /experiment="EXISTENCE:mutant phenotype:GO:0006665 sphingolipid metabolic process [PMID:23593226]" /experiment="EXISTENCE:mutant phenotype:GO:0008142 oxysterol binding [PMID:16136145]" /experiment="EXISTENCE:mutant phenotype:GO:0008289 lipid binding [PMID:20008566]" /experiment="EXISTENCE:mutant phenotype:GO:0015918 sterol transport [PMID:20008566]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:24213531]" /experiment="EXISTENCE:mutant phenotype:GO:0120015 sterol transfer activity [PMID:20008566]" /note="Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger; one of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication" /db_xref="GeneID:855958" /db_xref="SGD:S000006066" ORIGIN 1 msqyassssw tsflksiasf ngdlsslsap pfilspislt efsqywaehp elflepsfin 61 ddnykehcli dpevespela rmlavtkwfi stlksqycsr neslgsekkp lnpflgelfv 121 gkwenkehpe fgetvllseq vshhppvtaf sifndknkvk lqgynqikas ftkslmltvk 181 qfghtmldik desylvtppp lhiegilvas pfvelegksy iqsstgllcv iefsgrgyfs 241 gkknsfkari ykdskdskdk ekalytisgq wsgsskiika nkkeesrlfy daaripaehl 301 nvkpleeqhp lesrkawydv agaiklgdfn liaktktele etqrelrkee eakgiswqrr 361 wfkdfdysvt peegalvpek ddtflklasa lnlstknaps gtlvgdkedr kedlssihwr 421 fqrelwdeek eivl // LOCUS NP_015181 148 aa linear PLN 30-JUN-2025 DEFINITION Poc4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015181 VERSION NP_015181.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183958.1 REFERENCE 1 (residues 1 to 148) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 148) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 148) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 148) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 148) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11291. Method: conceptual translation. FEATURES Location/Qualifiers source 1..148 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..148 /product="Poc4p" /calculated_mol_wt="16442" Region 1..143 /region_name="POC3_POC4" /note="20S proteasome chaperone assembly proteins 3 and 4; pfam10448" /db_xref="CDD:402192" CDS 1..148 /gene="POC4" /locus_tag="YPL144W" /gene_synonym="DMP1; PBA4" /coded_by="NM_001183958.1:1..447" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17707236]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17707236|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0051131 chaperone-mediated protein complex assembly [PMID:17707236]" /experiment="EXISTENCE:mutant phenotype:GO:0043248 proteasome assembly [PMID:18278055|PMID:18260085]" /experiment="EXISTENCE:mutant phenotype:GO:0051131 chaperone-mediated protein complex assembly [PMID:17707236]" /experiment="EXISTENCE:physical interaction:GO:0051131 chaperone-mediated protein complex assembly [PMID:18278055]" /note="Component of a heterodimeric Poc4p-Irc25p chaperone; involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions; upregulates proteasome assembly in response to the unfolded protein response activated by mistargeting of proteins (UPRam)" /db_xref="GeneID:855959" /db_xref="SGD:S000006065" ORIGIN 1 mlvktisrti esesgflqpt ldviatlpad drskkipisl vvgfkqeasl nsssslscyy 61 yaiplmrdrh inlksggsnv vgiplldtkd drirdmarhm atiiserfnr pcyvtwsslp 121 sedpsmlvan hlyilkkcld llktelge // LOCUS NP_015182 107 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL33 RPL33A [Saccharomyces cerevisiae S288C]. ACCESSION NP_015182 VERSION NP_015182.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183957.1 REFERENCE 1 (residues 1 to 107) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 107) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 107) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 107) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11292. Method: conceptual translation. FEATURES Location/Qualifiers source 1..107 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..107 /product="60S ribosomal protein eL33 RPL33A" /calculated_mol_wt="12023" Region 7..100 /region_name="Ribosomal_L35Ae" /note="Ribosomal protein L35Ae; pfam01247" /db_xref="CDD:460132" CDS 1..107 /gene="RPL33A" /locus_tag="YPL143W" /gene_synonym="GCD17; RPL37A" /coded_by="NM_001183957.1:1..324" /experiment="EXISTENCE:direct assay:GO:0002181 cytoplasmic translation [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:18782943]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:18782943]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:17548477]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:17548477]" /note="Ribosomal 60S subunit protein L33A; N-terminally acetylated; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable; homologous to mammalian ribosomal protein L35A, no bacterial homolog; RPL33A has a paralog, RPL33B, that arose from the whole genome duplication" /db_xref="GeneID:855960" /db_xref="SGD:S000006064" ORIGIN 1 maeshrlyvk gkhlsyqrsk rvnnpnvsli kiegvatpqd aqfylgkria yvyraskevr 61 gskirvmwgk vtrthgnsgv vratfrnnlp aktfgasvri flypsni // LOCUS NP_015184 865 aa linear PLN 30-JUN-2025 DEFINITION protein kinase FRK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015184 VERSION NP_015184.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183955.1 REFERENCE 1 (residues 1 to 865) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 865) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 865) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 865) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 865) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 865) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 865) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11293. Method: conceptual translation. FEATURES Location/Qualifiers source 1..865 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..865 /product="protein kinase FRK1" /EC_number="2.7.11.1" /calculated_mol_wt="97562" Region 39..313 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(47..50,53,55,78,80,113,129..132,175,179..180,182, 192..193) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..865 /gene="FRK1" /locus_tag="YPL141C" /coded_by="NM_001183955.1:1..2598" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22289182|PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000011 vacuole inheritance [PMID:37509134]" /experiment="EXISTENCE:genetic interaction:GO:0045033 peroxisome inheritance [PMID:37509134]" /note="Protein kinase; minor role relative to Kin4p in regulating peroxisomal transport and vacuolar inheritance; protects the peroxisomal Myo2p receptor Inp2p from degradation in mother cells along with Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3p; FRK1 has a paralog, KIN4, that arose from the whole genome duplication" /db_xref="GeneID:855962" /db_xref="SGD:S000006062" ORIGIN 1 msytnkrhty yggftndlsd tfqypqrtde qrrkhvtfgp yilgstlgeg efgkvklgwp 61 knfsnssnst fdfpkqvaik likrdsisnd yrkevkiyre inalkhlshp nivkleevlq 121 nsryigivle yacggefyky iqkkrrlkem nacrlfsqli sgvhyihskg lvhrdlklen 181 llldknenlv itdfgfvnef csrnelmkts cgspcyaape lvisaepyea rkadiwscgv 241 ilyailagyl pwdddpnnpe gsdigrlyny instplkfpd yilpiprdll rrmlvsdpkk 301 rinlkqikkh ewlkphssfl sitpdewdkl nntqsvfrla kprrrygsrp qsscstsslg 361 srsdkrdslv idstlitfpa ppqesqnhii trpasiasdq rlspirrsnr hnrsnsaasv 421 alqavvnadr eyvlsheqsl spvqnirqtt gnmtaslspp paispgdiii ettpikrnti 481 sgssivpsle eessttmqts kiqpnnmass qnhqynknkt qnslqsaknf yrtsssshtk 541 prptsyhpgs yttppynsnt lsiyeineka kssassqtln qrdtspfdst pylaldtcit 601 ssssiesspk lithgqfsva kpsvdlqsvs gdlikykrda dvvtriydek ykqkrkslry 661 sgifsdiscd tvteesdelr ppesplqqhe gqesidkakt edtsekgsks sniakataqk 721 hvnnhlersl neaestkkrf sflslysydt sksslyssmd skrkpsppsq rrpkkddsyq 781 tnsknhyita snmqtshqvs kdlpaptmvq nkctletkka vrsnrssimv sevnkasvdn 841 kaaqspehst akrvlgffkr rsmki // LOCUS NP_015185 506 aa linear PLN 30-JUN-2025 DEFINITION putative mitogen-activated protein kinase kinase MKK2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015185 VERSION NP_015185.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183954.1 REFERENCE 1 (residues 1 to 506) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 506) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 506) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 506) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 506) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11294. Method: conceptual translation. FEATURES Location/Qualifiers source 1..506 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..506 /product="putative mitogen-activated protein kinase kinase MKK2" /EC_number="2.7.12.2" /calculated_mol_wt="56627" Region 212..499 /region_name="PKc_Pek1_like" /note="Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; cd06621" /db_xref="CDD:270793" Site order(220..224,228,241,243,274,292..295,298..299,302,342, 344..347,349,359..360,363,375..378,380,407,416) /site_type="active" /db_xref="CDD:270793" Site order(220..224,226,228,241,243,274,292..295,298..299, 301..302,344,346..347,349,360) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270793" Site order(223..224,342,344..346,363,375..378,380,407,416) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270793" Site 359..380 /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270793" CDS 1..506 /gene="MKK2" /locus_tag="YPL140C" /gene_synonym="LPI6; SSP33" /coded_by="NM_001183954.1:1..1521" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12361575]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12361575]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12361575]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12361575]" /experiment="EXISTENCE:genetic interaction:GO:0000196 cell integrity MAPK cascade [PMID:8386320]" /experiment="EXISTENCE:genetic interaction:GO:0000425 pexophagy [PMID:20385774]" /experiment="EXISTENCE:genetic interaction:GO:0060237 regulation of fungal-type cell wall organization [PMID:8386320]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:8386320]" /note="MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication" /db_xref="GeneID:855963" /db_xref="SGD:S000006061" ORIGIN 1 masmfrppes nrshqktpkl tlpvnlvqna kstndgqhln rspyssvnes pysnnstsat 61 sttssmasns tllynrsstt tiknrpvppp lpplvltqkk dgieyrvagd sqlserfsnl 121 hvditykell ssapistkls nidttfikkd ldtpegedsy pstllsaydf sssgsnsapl 181 sanniiscsn liqgkdvdql eeeawrfghl kdeittlgil gegaggsvak crlkngkkvf 241 alktintmnt dpeyqkqifr elqfnksfks dyivqyygmf tdeqsssiyi ameymggksl 301 eatyknllkr ggriservig kiaesvlrgl sylherkvih rdikpqnill nekgeiklcd 361 fgvsgeavns lamtftgtsf ymaperiqgq pysvtcdvws lgltllevag grfpfesdki 421 tqnvapiell tmiltfspql kdepeldisw sktfrsfidy clkkdarerp sprqmlkhpw 481 ivgqmkkkvn merfvkkcwe kekdgi // LOCUS NP_015186 460 aa linear PLN 30-JUN-2025 DEFINITION Ume1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015186 VERSION NP_015186.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183953.1 REFERENCE 1 (residues 1 to 460) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 460) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 460) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 460) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 460) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11295. Method: conceptual translation. FEATURES Location/Qualifiers source 1..460 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..460 /product="Ume1p" /calculated_mol_wt="50891" Region 187..232 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <191..309 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 243..274 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 281..335 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 344..400 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 416..441 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..460 /gene="UME1" /locus_tag="YPL139C" /gene_synonym="WTM3" /coded_by="NM_001183953.1:1..1383" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:9234739]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:25398614|PMID:9234739]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:25398614]" /experiment="EXISTENCE:direct assay:GO:0032221 Rpd3S complex [PMID:16286008|PMID:16286007]" /experiment="EXISTENCE:direct assay:GO:0033698 Rpd3L complex [PMID:16286008|PMID:16314178|PMID:16286007|PMID:19040720]" /experiment="EXISTENCE:direct assay:GO:0070210 Rpd3L-Expanded complex [PMID:19040720]" /experiment="EXISTENCE:mutant phenotype:GO:0016479 negative regulation of transcription by RNA polymerase I [PMID:19270272]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0040020 regulation of meiotic nuclear division [PMID:9234739]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20398213|PMID:17210643]" /note="Component of both the Rpd3S and Rpd3L histone deacetylase complexes; negative regulator of meiosis; required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p; UME1 has a paralog, WTM2, that arose from the whole genome duplication" /db_xref="GeneID:855964" /db_xref="SGD:S000006060" ORIGIN 1 mstldiaedn kikneefkiw kksipslyqh isslkpifgs gvdespstlr sivftndssc 61 nkskgvlsvp llysqgseif evdcivplgl hykkpesise plvqpdytme sqkveqtvli 121 pkwefkgeti akmiyvdnse invkvialst ngslawfreg vkspvytmme pstslssass 181 gnqnkpcvdf aisndsktlt vtkekhldne natiklidns gkigevlrti pvpgikniqe 241 ikflnnqifa tcsddgiirf wgneigkkpl wilndsldgk ttcfaaspfv dtlfmtgtsg 301 galkvwdira vialgdadae lninqghnkv nelfkvhhfy seqvskiefs sispmevvti 361 gglgnvyhwn fepvfaiyne ihedfqgiis deleaesmaf yhtegcrrei gennkvntva 421 yhkyiedlva tvdsdglltv ykpftgkvld gsrevgaaks // LOCUS NP_015187 353 aa linear PLN 30-JUN-2025 DEFINITION Spp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015187 VERSION NP_015187.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183952.1 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11296. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..353 /product="Spp1p" /calculated_mol_wt="41337" Region 24..69 /region_name="PHD_SPP1" /note="PHD finger found in Set1 complex component SPP1; cd16039" /db_xref="CDD:277186" Site order(24,35..39,43,64) /site_type="other" /note="putative histone H3 binding site [polypeptide binding]" /db_xref="CDD:277186" CDS 1..353 /gene="SPP1" /locus_tag="YPL138C" /gene_synonym="CPS40; SAF41" /coded_by="NM_001183952.1:1..1062" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:17898715]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:18845545]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0042800 histone H3K4 methyltransferase activity [PMID:11805083|PMID:11742990]" /experiment="EXISTENCE:direct assay:GO:0045815 transcription initiation-coupled chromatin remodeling [PMID:17898715]" /experiment="EXISTENCE:direct assay:GO:0140002 histone H3K4me3 reader activity [PMID:17142463]" /experiment="EXISTENCE:direct assay:GO:0140006 histone H3 reader activity [PMID:17898715]" /experiment="EXISTENCE:mutant phenotype:GO:0003682 chromatin binding [PMID:23246437]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11687631]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:11687631|PMID:11752412|PMID:11805083]" /experiment="EXISTENCE:mutant phenotype:GO:0042800 histone H3K4 methyltransferase activity [PMID:11752412]" /experiment="EXISTENCE:mutant phenotype:GO:1903341 regulation of meiotic DNA double-strand break formation [PMID:23246437]" /experiment="EXISTENCE:physical interaction:GO:0048188 Set1C/COMPASS complex [PMID:11687631|PMID:11742990|PMID:11752412]" /note="Subunit of COMPASS (Set1C); a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; promotes meiotic DSB formation by interacting with H3K4me3 and Rec107p, a protein required for Spo11p-catalyzed DSB formation located on chromosome axes; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein; relocalizes to cytosol in response to hypoxia" /db_xref="GeneID:855965" /db_xref="SGD:S000006059" ORIGIN 1 mslpqwcpph stlkrnpttg edvycickrp dygelmvgcd gcddwfhftc lhipeqfkdl 61 vfsfycpycq agitgknkda iingegslpk tlwkrkcris dcykpclqds kycseehgre 121 fvndiwsrlk tdedravvkk mveqtghidk fkkfgqldfi dnnivvktdd ekeifdqivv 181 rdmtlktled dlqevqeisl plfkkklell evylgwldnv ytemrklddd aashvecgke 241 dskgtkrkkk knssrsrark nicgycstye ripcsveefv rdfgsneeat kihevctkwk 301 cnrhldwvst nqeqylqqid slesmqerlq hliqarkkql niqyyeeilr rgl // LOCUS NP_015188 1276 aa linear PLN 30-JUN-2025 DEFINITION protein phosphatase regulator GIP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015188 VERSION NP_015188.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183951.1 REFERENCE 1 (residues 1 to 1276) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1276) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1276) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1276) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1276) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11297. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1276 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1276 /product="protein phosphatase regulator GIP3" /calculated_mol_wt="140760" Region <842..>1004 /region_name="PRK04132" /note="replication factor C small subunit; Provisional" /db_xref="CDD:235223" CDS 1..1276 /gene="GIP3" /locus_tag="YPL137C" /coded_by="NM_001183951.1:1..3831" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008157 protein phosphatase 1 binding [PMID:11841235]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16537909]" /experiment="EXISTENCE:mutant phenotype:GO:0019888 protein phosphatase regulator activity [PMID:16537909]" /note="Cytoplasmic protein that regulates protein phosphatase 1 Glc7p; overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments; GIP3 has a paralog, HER1, that arose from the whole genome duplication" /db_xref="GeneID:855967" /db_xref="SGD:S000006058" ORIGIN 1 mitntefdvp vdwlykgksr rktntkpsrp stspasssst ssskngdnst sgnrssndkp 61 rarsssvsna alcntekpdl krndgntsas dtdniplltp insgnrsdsa didnpatvda 121 idlidnddng sstqfvrkkr stsisnavvs skprlassai natasssvgk gkhppissps 181 natlkrsnst sgektkrsif gslfskrsts ssastakkpl pvvntstten esggikavat 241 pdprvkeiss pmrgvaptas kpqtpilpsp alavkdlstv slkrvsfavd kfesdppqql 301 psrtpkkgni lipddmisev psisvgisss nqsakstnsn ikgplytkks keyilalenq 361 klalreaakh qqeahfaanr iafevanfkt asdaggklte kssegtitkq reevsppnve 421 adrelennkl aenlskagid kpihmhehyf kepdqdkyqd ghsiennevt ldviytrcch 481 lreilpipst lrqvkdktap lqilkflnpk ptlidilsfc dfitiapiht ivfdnvalnq 541 dmfriiisal vnstvldkls lrnvridqdg wkllckflll nkslnkldis qtkiksdlae 601 slyrhnmdwn lftdvlsqrs hkpieellfn giqfskipys cfarlltsfa tqknfpesgi 661 rlglagatts nisqdclkfi fnwmsqynvq gvdlafndls tmikpmvgkl salsydnlry 721 filnstnist sydlalllky lsklpnlifl dlsnlsqcfp dilpymykyl prfpnlkrih 781 ldsnnltlke lavvcnilik ckslshvsmt nqnvenfylm ngtdspvqqt ntdgdldsss 841 tldvkgqfak nsfsstlyaf ardspnligl dfdydlisee iqsrialclm rnmkrtmdst 901 fqldeldsqd dllfdgslvt mtaesvlekl nllsdkstkv kkdttkryll kkyiekfhil 961 hhnvqhtidt mfekrksgel plqekenlvr lllleqnlcn ilelfshnpn lndvlgssrd 1021 dskesvdsse dsklpalkhv esgyhvpeek iqpendvita rphlmatdsg ktidvftgkp 1081 lvfkhtssst svgckkqeee egelhkwgff vqqqrslype nestrqtpfa sgdtpintet 1141 agkstsspsv stsnnetatt slfspanpki lpkipsgavl rsaimkakgi dsiddliqnv 1201 nsnnieleni ygesiqnsas tftpgvdsdv sapntdkgsv etlpavstdd pncevkvtat 1261 ydkllnnlsm ersirl // LOCUS NP_015190 165 aa linear PLN 30-JUN-2025 DEFINITION iron-binding protein ISU1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015190 VERSION NP_015190.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183949.1 REFERENCE 1 (residues 1 to 165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 165) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11298. Method: conceptual translation. FEATURES Location/Qualifiers source 1..165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..165 /product="iron-binding protein ISU1" /calculated_mol_wt="17764" Site order(34..37,40..41,69..70,96,98,135..136,138..139) /site_type="other" /note="trimerization site [polypeptide binding]" /db_xref="CDD:143480" Region 35..159 /region_name="iscU" /note="FeS cluster assembly scaffold IscU; TIGR01999" /db_xref="CDD:188192" Site order(69,96,139) /site_type="active" /db_xref="CDD:143480" CDS 1..165 /gene="ISU1" /locus_tag="YPL135W" /gene_synonym="NUA1" /coded_by="NM_001183949.1:1..498" /experiment="EXISTENCE:direct assay:GO:0001671 ATPase activator activity [PMID:12756240]" /experiment="EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:31532427]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10468587|PMID:15143178]" /experiment="EXISTENCE:direct assay:GO:0008198 ferrous iron binding [PMID:12970193]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:31532427]" /experiment="EXISTENCE:genetic interaction:GO:0002098 tRNA wobble uridine modification [PMID:17283054]" /experiment="EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:12970193]" /experiment="EXISTENCE:mutant phenotype:GO:0006879 intracellular iron ion homeostasis [PMID:10468587]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:31040179|PMID:15143178|PMID:10588895]" /note="Conserved protein of the mitochondrial matrix; performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); ISU1 has a paralog, ISU2, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant" /db_xref="GeneID:855968" /db_xref="SGD:S000006056" ORIGIN 1 mlpvitrfar palmairpvn amgvlrassi tkrlyhpkvi ehythprnvg sldkklpnvg 61 tglvgapacg dvmrlqikvn dstgviedvk fktfgcgsai asssymtelv qgmtlddaak 121 iknteiakel slppvklhcs mlaedaikaa ikdykskrnt ptmls // LOCUS NP_015191 310 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 2-oxodicarboxylate carrier [Saccharomyces cerevisiae S288C]. ACCESSION NP_015191 VERSION NP_015191.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183948.1 REFERENCE 1 (residues 1 to 310) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 310) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 310) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 310) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 310) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11299. Method: conceptual translation. FEATURES Location/Qualifiers source 1..310 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..310 /product="mitochondrial 2-oxodicarboxylate carrier" /calculated_mol_wt="34075" Region 8..113 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 11..302 /region_name="PTZ00169" /note="ADP/ATP transporter on adenylate translocase; Provisional" /db_xref="CDD:240302" CDS 1..310 /gene="ODC1" /locus_tag="YPL134C" /coded_by="NM_001183948.1:1..933" /experiment="EXISTENCE:direct assay:GO:0005310 dicarboxylic acid transmembrane transporter activity [PMID:11013234]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:9178508|PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11013234]" /experiment="EXISTENCE:direct assay:GO:0006839 mitochondrial transport [PMID:11013234]" /note="Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication" /db_xref="GeneID:855969" /db_xref="SGD:S000006055" ORIGIN 1 mtsidnrplp fiyqftagai agvsellvmy pldvvktrmq lqvttkghpa vvaakaavdh 61 ytgvmdcltk ivkkegfshl ykgitspilm eapkraikfs gndtfqtfyk kifptpngem 121 tqkiaiysga sagaveafvv apfelvkirl qdvnsqfktp ievvknsvvk ggvlslfngl 181 eatiwrhvlw nagyfgiifq irkllpaakt stektrndli agaiggtvgc llntpfdvvk 241 sriqrssgpl rkynwslpsv llvyreegfk alykgfapkv mrlapgggll lvvftnvmdf 301 frevkygkkq // LOCUS NP_015192 446 aa linear PLN 30-JUN-2025 DEFINITION gluconeogenesis transcription factor RDS2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015192 VERSION NP_015192.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183947.1 REFERENCE 1 (residues 1 to 446) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 446) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 446) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 446) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11300. Method: conceptual translation. FEATURES Location/Qualifiers source 1..446 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..446 /product="gluconeogenesis transcription factor RDS2" /calculated_mol_wt="49951" Region 11..53 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(12,16,21..24,26,29,38) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(17,20,27,33,36) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" CDS 1..446 /gene="RDS2" /locus_tag="YPL133C" /coded_by="NM_001183947.1:1..1341" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:17875938]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:17875938]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:17875938]" /experiment="EXISTENCE:mutant phenotype:GO:0045722 positive regulation of gluconeogenesis [PMID:17875938]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11943786|PMID:17875938]" /experiment="EXISTENCE:mutant phenotype:GO:0071466 cellular response to xenobiotic stimulus [PMID:11943786]" /note="Transcription factor involved in regulating gluconeogenesis; also involved in the regulation of glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole" /db_xref="GeneID:855970" /db_xref="SGD:S000006054" ORIGIN 1 msansgvkra skafktclfc krshvvcdkq rpcsrcvkrd iahlcreddi avpnempsqh 61 esspndnniq gkyankahtg ipsdyqnepv nksgstygee lspkldsslv ndttslllpq 121 qpvfvsenvg sefsslnefl smlenplltq tslssssasn vhlengsqtt qspleyqndn 181 rrdeigvarq enrsptimsg ssnsiskgdk qdqekeesri lananensap tpkeqfflta 241 adpstemtpe hrlklvinak leagllkpyn yakgyarlqd ymdkymnqss kqrilkplst 301 irpafrtiar slkdvdlvlv eesfermlls ydrvftsmsm paclcrrtge iyrankefas 361 lvdctvddlr dgklaiyelm teesavnfwe kygsiafdkg qkavltscsl rtkdgirkrp 421 ccfsftirrd rynipicivg nfipls // LOCUS NP_015193 300 aa linear PLN 30-JUN-2025 DEFINITION Cox11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015193 VERSION NP_015193.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183946.1 REFERENCE 1 (residues 1 to 300) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 300) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 300) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 300) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11301. Method: conceptual translation. FEATURES Location/Qualifiers source 1..300 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..300 /product="Cox11p" /calculated_mol_wt="33913" Region 103..254 /region_name="CtaG_Cox11" /note="Cytochrome c oxidase assembly protein CtaG/Cox11; pfam04442" /db_xref="CDD:461313" CDS 1..300 /gene="COX11" /locus_tag="YPL132W" /gene_synonym="LPI13; PSO7" /coded_by="NM_001183946.1:1..903" /experiment="EXISTENCE:direct assay:GO:0005507 copper ion binding [PMID:12063264]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:2167832]" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:2167832]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:10501934|PMID:15776235]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:22984289]" /experiment="EXISTENCE:direct assay:GO:0005761 mitochondrial ribosome [PMID:15776235]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:10617659]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:34919594]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:2167832]" /note="Protein required for delivery of copper to Cox1p; mitochondrial inner membrane protein; involved in oxidative stress response; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p" /db_xref="GeneID:855971" /db_xref="SGD:S000006053" ORIGIN 1 miricpivrs kvpllgtflr sdswlaphal alrraicknv alrsysvnse qpkhtfdisk 61 ltrneiqqlr elkrarerkf kdrtvafyfs svavlflgla yaavplyrai cartgfggip 121 itdrrkftdd klipvdtekr irisftsevs qilpwkfvpq qrevyvlpge talafykakn 181 ysdkdiigma tysiapgeaa qyfnkiqcfc feeqklaage eidmpvfffi dpdfasdpam 241 rniddiilhy tffrahygdg tavsdskkep emnadekaas lanaailspe vidtrkdnsn // LOCUS NP_015194 297 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL18 RPL5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015194 VERSION NP_015194.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183945.1 REFERENCE 1 (residues 1 to 297) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 297) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 297) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 297) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 297) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11302. Method: conceptual translation. FEATURES Location/Qualifiers source 1..297 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..297 /product="60S ribosomal protein uL18 RPL5" /calculated_mol_wt="33584" Region 1..282 /region_name="PTZ00069" /note="60S ribosomal protein L5; Provisional" /db_xref="CDD:240254" CDS 1..297 /gene="RPL5" /locus_tag="YPL131W" /gene_synonym="LPI14; RPL1" /coded_by="NM_001183945.1:1..894" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0008097 5S rRNA binding [PMID:8764831]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:8474444]" /note="Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly" /db_xref="GeneID:855972" /db_xref="SGD:S000006052" ORIGIN 1 mafqkdakss ayssrfqtpf rrrregktdy yqrkrlvtqh kakyntpkyr lvvrftnkdi 61 icqiisstit gdvvlaaays helprygith gltnwaaaya tglliarrtl qklgldetyk 121 gveevegeye lteavedgpr pfkvfldigl qrtttgarvf galkgasdgg lyvphsenrf 181 pgwdfeteei dpellrsyif gghvsqymee ladddeerfs elfkgyladd idadslediy 241 tsaheairad pafkptekkf tkeqyaaesk kyrqtklske eraarvaaki aalagqq // LOCUS NP_015195 223 aa linear PLN 30-JUN-2025 DEFINITION Spo19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015195 VERSION NP_015195.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183944.1 REFERENCE 1 (residues 1 to 223) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 223) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 223) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 223) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11303. Method: conceptual translation. FEATURES Location/Qualifiers source 1..223 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..223 /product="Spo19p" /calculated_mol_wt="24858" CDS 1..223 /gene="SPO19" /locus_tag="YPL130W" /coded_by="NM_001183944.1:1..672" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:18756268]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:10383953]" /experiment="EXISTENCE:genetic interaction:GO:0051321 meiotic cell cycle [PMID:17179081]" /experiment="EXISTENCE:genetic interaction:GO:0070583 spore membrane bending pathway [PMID:18756268]" /experiment="EXISTENCE:mutant phenotype:GO:0070583 spore membrane bending pathway [PMID:18756268]" /note="Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation; SPO19 has a paralog, YOR214C, that arose from the whole genome duplication" /db_xref="GeneID:855973" /db_xref="SGD:S000006051" ORIGIN 1 mkkqilivaa qsilcstvfg ersnvglste elggdsilyf nedpivieid kkaidkktle 61 qlastrdvvl tdlpdtlefi dfneyakmks ksdmlleyin eyefddfers seggleeeee 121 edliydfnaq aedlgklgsn iyevveekni vntydgnlin asttesttti rpfvtshsyv 181 asstpysnis slnedydnas nfltpttval avlltillfi qay // LOCUS NP_015196 244 aa linear PLN 30-JUN-2025 DEFINITION TATA-binding protein-associated factor TAF14 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015196 VERSION NP_015196.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183943.1 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11304. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..244 /product="TATA-binding protein-associated factor TAF14" /calculated_mol_wt="27309" Region 2..242 /region_name="TFG3" /note="Transcription initiation factor IIF, auxiliary subunit [Transcription]; COG5033" /db_xref="CDD:227366" CDS 1..244 /gene="TAF14" /locus_tag="YPL129W" /gene_synonym="ANC1; SWP29; TAF30; TFG3" /coded_by="NM_001183943.1:1..735" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:35970389]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0005674 transcription factor TFIIF complex [PMID:7995524|PMID:12242279|PMID:15896708]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12887900]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:12138208|PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0006367 transcription initiation at RNA polymerase II promoter [PMID:35970389|PMID:1331084]" /experiment="EXISTENCE:direct assay:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:14749386]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:18644858]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:8187178]" /experiment="EXISTENCE:direct assay:GO:0031011 Ino80 complex [PMID:12887900]" /experiment="EXISTENCE:direct assay:GO:0033100 NuA3 histone acetyltransferase complex [PMID:10817755|PMID:17157260]" /experiment="EXISTENCE:direct assay:GO:1990467 NuA3a histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:direct assay:GO:1990468 NuA3b histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:physical interaction:GO:0005674 transcription factor TFIIF complex [PMID:15896708]" /experiment="EXISTENCE:physical interaction:GO:0031011 Ino80 complex [PMID:24034245]" /note="Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; serves as an additional DNA binding domain for the complex; contains a YEATS domain" /db_xref="GeneID:855974" /db_xref="SGD:S000006050" ORIGIN 1 mvatvkrtir iktqqhilpe vppvenfpvr qwsieivlld degkeipati fdkviyhlhp 61 tfanpnrtft dppfrieeqg wggfpldisv fllekagerk iphdlnflqe syevehviqi 121 plnkplltee laksgsteet tantgtigkr rtttnttaep kakraktgsa stvkgsvdle 181 klafgltkln eddlvgvvqm vtdnktpemn vtnnveegef iidlyslpeg llkslwdyvk 241 knte // LOCUS NP_015197 562 aa linear PLN 30-JUN-2025 DEFINITION Tbf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015197 VERSION NP_015197.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183942.1 REFERENCE 1 (residues 1 to 562) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 562) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 562) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 562) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 562) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11305. Method: conceptual translation. FEATURES Location/Qualifiers source 1..562 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..562 /product="Tbf1p" /calculated_mol_wt="62693" Region 32..283 /region_name="TRF" /note="Telomere repeat binding factor (TRF); pfam08558" /db_xref="CDD:400735" Region 410..462 /region_name="SANT_TRF" /note="Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; cd11660" /db_xref="CDD:212558" Site order(410..412,431..432,451,453..455,457..459,461..462) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:212558" CDS 1..562 /gene="TBF1" /locus_tag="YPL128C" /gene_synonym="LPI16" /coded_by="NM_001183942.1:1..1689" /experiment="EXISTENCE:direct assay:GO:0000781 chromosome, telomeric region [PMID:20513435]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:20513435]" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:20513435]" /experiment="EXISTENCE:direct assay:GO:0001015 snoRNA transcription by RNA polymerase II [PMID:20513435]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0010833 telomere maintenance via telomere lengthening [PMID:17917674]" /experiment="EXISTENCE:direct assay:GO:0042162 telomeric DNA binding [PMID:20513435]" /experiment="EXISTENCE:direct assay:GO:0043035 chromatin insulator sequence binding [PMID:11258704]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:23222485]" /experiment="EXISTENCE:genetic interaction:GO:0032211 negative regulation of telomere maintenance via telomerase [PMID:16467854]" /experiment="EXISTENCE:mutant phenotype:GO:0001015 snoRNA transcription by RNA polymerase II [PMID:20513435]" /experiment="EXISTENCE:mutant phenotype:GO:0006303 double-strand break repair via nonhomologous end joining [PMID:23222485]" /experiment="EXISTENCE:mutant phenotype:GO:0006338 chromatin remodeling [PMID:23222485]" /note="Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flanked by long T2AG3 repeats and blocks checkpoint activation; involved in nucleosome displacement during double-strand break repair" /db_xref="GeneID:855975" /db_xref="SGD:S000006049" ORIGIN 1 mdsqvpnnne slnrfndiiq slpartrlti cslclldnis tqllrfliln anspniiavl 61 tdqtaflssg eteifqtlvk lfkqirmiyh trspllsvhd vapglwfpns ppplilrghe 121 afiitairka nlltflltsl nclnygfell qsifldifcp ntntvgnnsl eqsgkflksq 181 ailyldlktq ayiaglkefq detneislek kqelldlifp snladilvqr rtgdsgditl 241 ltpsekdfve rcdrrrenlk ivqdfnsltq syewaqfire lldycnknmg liiwgrkgrg 301 ksplydfdvn efdpqvlfst gtrtvefmdd qnqpssasaf lstarpnhys thtpttdvss 361 knpaitqsiv daavaasmsn sssgphsshn nssnsnnngs iglrkpkakr twskeeeeal 421 veglkevgps wskildlygp ggkitenlkn rtqvqlkdka rnwklqylks gkplpdylik 481 vtgnlekiyk akkkfsqspn sstimeqnls qhpssaasat edtqthqeds hgqnsdnmps 541 nglfgnstsd ntgfdphled gm // LOCUS NP_015198 258 aa linear PLN 30-JUN-2025 DEFINITION histone H1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015198 VERSION NP_015198.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183941.1 REFERENCE 1 (residues 1 to 258) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 258) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 258) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 258) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 258) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11306. Method: conceptual translation. FEATURES Location/Qualifiers source 1..258 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..258 /product="histone H1" /calculated_mol_wt="27673" Region 45..108 /region_name="Linker_histone" /note="linker histone H1 and H5 family; pfam00538" /db_xref="CDD:459846" Region 179..245 /region_name="Linker_histone" /note="linker histone H1 and H5 family; pfam00538" /db_xref="CDD:459846" CDS 1..258 /gene="HHO1" /locus_tag="YPL127C" /coded_by="NM_001183941.1:1..777" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:22586276]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:11574687]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276|PMID:9046096]" /experiment="EXISTENCE:mutant phenotype:GO:0006355 regulation of DNA-templated transcription [PMID:11574687]" /experiment="EXISTENCE:mutant phenotype:GO:0030261 chromosome condensation [PMID:22586276]" /experiment="EXISTENCE:mutant phenotype:GO:0043934 sporulation [PMID:22586276]" /experiment="EXISTENCE:mutant phenotype:GO:0045910 negative regulation of DNA recombination [PMID:12820979]" /experiment="EXISTENCE:mutant phenotype:GO:2000779 regulation of double-strand break repair [PMID:31821952]" /note="Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination" /db_xref="GeneID:855976" /db_xref="SGD:S000006048" ORIGIN 1 mapkksttkt tskgkkpats kgkekstska aikkttakke eassksyrel iiegltalke 61 rkgssrpalk kfikenypiv gsasnfdlyf nnaikkgvea gdfeqpkgpa gavklakkks 121 pevkkekevs pkpkqaatsv sataskakaa stklapkkvv kkksptvtak kasspsslty 181 kemilksmpq lndgkgssri vlkkyvkdtf ssklktssnf dylfnsaikk cvengelvqp 241 kgpsgiikln kkkvklst // LOCUS NP_015199 896 aa linear PLN 30-JUN-2025 DEFINITION Nan1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015199 VERSION NP_015199.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183940.1 REFERENCE 1 (residues 1 to 896) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 896) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 896) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 896) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 896) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 896) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 896) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11307. Method: conceptual translation. FEATURES Location/Qualifiers source 1..896 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..896 /product="Nan1p" /calculated_mol_wt="101106" Region <250..>353 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 260..295 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 300..326 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..896 /gene="NAN1" /locus_tag="YPL126W" /gene_synonym="UTP17" /coded_by="NM_001183940.1:1..2691" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0033553 rDNA heterochromatin [PMID:15489292]" /experiment="EXISTENCE:direct assay:GO:0034455 t-UTP complex [PMID:17515605]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:12068309]" /experiment="EXISTENCE:mutant phenotype:GO:0045943 positive regulation of transcription by RNA polymerase I [PMID:15489292]" /note="U3 snoRNP protein; component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA; localizes to nucleolus and peroxisomes" /db_xref="GeneID:855977" /db_xref="SGD:S000006047" ORIGIN 1 mtqslgieqy klsvvsggkp alnnlssvtg nkniarlsqd qrnyiipfnn qikvysvetr 61 qcvktlkfan nsllsgiflq eeennesivk illgditvpq qedahlitvf tnnghvivln 121 ykgklvespk hfkisladek lanvfhsegn yrilttfkdp sqkahnslqs yrlyaltfdd 181 akkqfevahq aewhnvilsn issngkllah mckdvstkdh ehksisvvsl fddsvnlsfp 241 lgsilssqtq slsyntryvs smaidnmgqq lavgfasgvi sivsladlqi rllkwhidsv 301 lslsfshdgs yllsggwekv mslwqletns qqflprlngi iidcqvlgpq gnyyslilqm 361 tennsnsdyq flllnasdlt sklsingplp vfnstikhiq qpisamntkn snsitslnhs 421 kkkqsrklik srrqdfttnv einpinknly fphisavqif dfykneqvny qyltsgvnns 481 mgkvrfelnl qdpiitdlkf tkdgqwmity eieyppndll sskdlthilk fwtkndnetn 541 wnlktkvinp hgisvpitki lpsprsvnns qgcltadnng glkfwsfdsh esnwclkkis 601 lpnfnhfsns vslawsqdgs lifhgfddkl qildfdtfkk feslentktv seftldseiq 661 tvklindtnl ivatrttlna inllrgqvin sfdlypfvng vyknghmdrl itcdertgni 721 alvinqqltd ldgvptinyk sriiifdsdl stklgnfthh eyiswigwny dtdfifldie 781 stlgvvgttv ntqlsdevnn egildglvsn tittsasnsd ifaeqlhkls srgkksdtrd 841 kntndndede edialefing ekkdklvnmn sftsmfdniq nvqmdtffdr vmkvlt // LOCUS NP_015200 1032 aa linear PLN 30-JUN-2025 DEFINITION karyopherin KAP120 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015200 VERSION NP_015200.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183939.1 REFERENCE 1 (residues 1 to 1032) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1032) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1032) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1032) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1032) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1032) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1032) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11308. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1032 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1032 /product="karyopherin KAP120" /calculated_mol_wt="119492" Region 8..1023 /region_name="CSE1" /note="CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]; COG5657" /db_xref="CDD:227944" CDS 1..1032 /gene="KAP120" /locus_tag="YPL125W" /gene_synonym="LPH2" /coded_by="NM_001183939.1:1..3099" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:16581791|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0006606 protein import into nucleus [PMID:20219973]" /experiment="EXISTENCE:direct assay:GO:0008139 nuclear localization sequence binding [PMID:20219973]" /experiment="EXISTENCE:direct assay:GO:0061608 nuclear import signal receptor activity [PMID:20219973]" /experiment="EXISTENCE:mutant phenotype:GO:0006606 protein import into nucleus [PMID:20219973|PMID:16581791]" /experiment="EXISTENCE:mutant phenotype:GO:0061608 nuclear import signal receptor activity [PMID:20219973]" /experiment="EXISTENCE:physical interaction:GO:0006606 protein import into nucleus [PMID:16581791]" /note="Karyopherin responsible for the nuclear import of Rpf1p; Rpf1p is a ribosome maturation factor" /db_xref="GeneID:855978" /db_xref="SGD:S000006046" ORIGIN 1 masslnelnl vqvleqasnp qhirsdvqkl aeqqlrqwet qagfhyllqs iylnlsnslq 61 irwlaviqfk ngvdkywrst rinaipkdek asirgrlfem ideqnnqlci qnaqasaria 121 rldfpvewpt lfedlenlln deiirkdsvk iynilmhinq ivkvlgtari grcrpamqsk 181 vplilplivr iylqsfeewt tssnlnyedl sslqvsylal kvlrriiceg ydrpqtdqsv 241 cdfiklsvsh femlisnhen fkkfdiyekf ikclgklyfn lvtgspanfi llpcstqili 301 tytrlifdka pkvyrensdv tgdfweqtai rgllilkrvi nfihkkgait lkarsdklti 361 dasinkinte flnenlitrl vdtlmewylr lrptelenwf mdpeewineq matsyeyqir 421 pcaenvfqdl mntfsellvp yllkkienda sklsnslddf lrkdaiyasf qlsasavsem 481 vdfdrlliqv flpeatntni sgdelriirr rvaliinews tvkcseesks lcyklftnfl 541 tdeddkvvll ttvqtvrtmv ddwnfnkdtf qpfltenvhl llrkilpsvs ltetrlyvln 601 tlsdiiiqtk plisrdllve ilqiipnlwe iatnnaseai lanallrllr nlvsslgsqs 661 hltwdiaipv valacdpssm qyqllsedgy elwgmllqnf sshdqefddk fvelvpflky 721 giethteilp tlleiiksya lilnpvdffs nntfqdifkq mskyllklre dsfqlvleiw 781 eililsnesd yenlllqkfy etgvlsalfd aifleeapss ylcsqiiqii arisyvnpda 841 lmtflatyhd nlptsnenar mpesirkivs kdqtydsvvn klltgwivcf rdifdpkfkk 901 vhilgissll rtglvpilte fssiaslwie mleeinetnr gdcekyhlnd ivteqsiafh 961 pltaeqlryh qlcknndpvh nislkdfisq smeyleshlg veryqeflkt inpsllenlq 1021 mflsiqpqea rp // LOCUS NP_015201 253 aa linear PLN 30-JUN-2025 DEFINITION Spc29p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015201 VERSION NP_015201.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183938.1 REFERENCE 1 (residues 1 to 253) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 253) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 253) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 253) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 253) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11309. Method: conceptual translation. FEATURES Location/Qualifiers source 1..253 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..253 /product="Spc29p" /calculated_mol_wt="29149" Region 1..251 /region_name="Spc29" /note="Spindle Pole Component 29; pfam17082" /db_xref="CDD:293687" CDS 1..253 /gene="SPC29" /locus_tag="YPL124W" /gene_synonym="LPH3; NIP29" /coded_by="NM_001183938.1:1..762" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0061493 central plaque of mitotic spindle pole body [PMID:10339566]" /experiment="EXISTENCE:mutant phenotype:GO:1903087 mitotic spindle pole body duplication [PMID:10330408|PMID:10339566]" /note="Inner plaque spindle pole body (SPB) component; links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication" /db_xref="GeneID:855979" /db_xref="SGD:S000006045" ORIGIN 1 mdysnfgnsa skkfqddtln rvrkeheeal kklreenfss ntselgnkkh yraqermssp 61 lhrlsptgks ddrkvkspld dklrrqlreg ntrlppppfs sygmpptnrs nldrirrrts 121 spvrtdkfas qnviddqrle ikylerivyd qgtvidnlts ritrlesfil nsisdrgdkn 181 faslehsrsf sgfptnktyg lqmgglyend mpyrrssdni nkegaredrs sqihienest 241 edilkilsss fhn // LOCUS NP_015202 434 aa linear PLN 30-JUN-2025 DEFINITION ribonuclease T2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015202 VERSION NP_015202.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183937.1 REFERENCE 1 (residues 1 to 434) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 434) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 434) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 434) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 434) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11310. Method: conceptual translation. FEATURES Location/Qualifiers source 1..434 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..434 /product="ribonuclease T2" /EC_number="4.6.1.19" /calculated_mol_wt="50041" Region 50..284 /region_name="RNase_T2_euk" /note="Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; cd01061" /db_xref="CDD:238512" Site order(54,90,251) /site_type="other" /note="B1 nucleotide binding pocket [chemical binding]" /db_xref="CDD:238512" Site order(58,63,152,249) /site_type="other" /note="B2 nucleotide binding pocket [chemical binding]" /db_xref="CDD:238512" Site order(84..91,152..163) /site_type="active" /note="CAS motifs [active]" /db_xref="CDD:238512" Site order(87,90,92,155..156,159..160) /site_type="active" /db_xref="CDD:238512" CDS 1..434 /gene="RNY1" /locus_tag="YPL123C" /coded_by="NM_001183937.1:1..1305" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:24102742]" /experiment="EXISTENCE:direct assay:GO:0004521 RNA endonuclease activity [PMID:11158587]" /experiment="EXISTENCE:direct assay:GO:0005576 extracellular region [PMID:11158587]" /experiment="EXISTENCE:direct assay:GO:0005773 vacuole [PMID:19332891]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:19332891|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006915 apoptotic process [PMID:19332891]" /experiment="EXISTENCE:mutant phenotype:GO:0000902 cell morphogenesis [PMID:11158587]" /experiment="EXISTENCE:mutant phenotype:GO:0004521 RNA endonuclease activity [PMID:19332891]" /experiment="EXISTENCE:mutant phenotype:GO:0006401 RNA catabolic process [PMID:19332891]" /experiment="EXISTENCE:mutant phenotype:GO:0006402 mRNA catabolic process [PMID:33875662]" /note="Vacuolar RNase of the T(2) family; relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; required for tRNA-specific translational pausing during oxidative stress; promotes apoptosis under stress conditions and this function is independent of Rny1p catalytic activity" /db_xref="GeneID:855980" /db_xref="SGD:S000006044" ORIGIN 1 mllknlhsll qlpifsngad kgiepncpin iplscsnktd idnsccfeyp ggiflqtqfw 61 nyfpskndln etelvkelgp ldsftihglw pdnchggyqq fcnrslqidd vyyllhdkkf 121 nnndtslqis geklleyldl ywksnngnhe slwihefnkh gtcistirpe cytewgansv 181 drkravydyf ritynlfkkl dtfstleknn ivpsvdnsys leqieaalsk efegkkvfig 241 cdrhnslnev wyynhlkgsl lsemfvpmds lairtnckkd gikffpkgyv ptfrrrpnkg 301 aryrgvvrls ninngdqmqg fliknghwms qgtpanyeli kspygnyylr tnqgfcdiis 361 sssnelvckf rnikdagqfd fdptkggdgy igysgnynwg gdtyprrrnq spifsvddeq 421 nskkykfklk fikn // LOCUS NP_015203 513 aa linear PLN 30-JUN-2025 DEFINITION TFIIH/NER complex subunit TFB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015203 VERSION NP_015203.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183936.1 REFERENCE 1 (residues 1 to 513) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 513) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 513) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 513) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11311. Method: conceptual translation. FEATURES Location/Qualifiers source 1..513 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..513 /product="TFIIH/NER complex subunit TFB2" /calculated_mol_wt="58404" Region 9..510 /region_name="Tfb2" /note="Transcription factor Tfb2; cl04289" /db_xref="CDD:470994" CDS 1..513 /gene="TFB2" /locus_tag="YPL122C" /coded_by="NM_001183936.1:1..1542" /experiment="EXISTENCE:direct assay:GO:0000439 transcription factor TFIIH core complex [PMID:14500720|PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:19897425]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:9235928]" /experiment="EXISTENCE:physical interaction:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:10681587]" /note="Subunit of TFIIH and nucleotide excision repair factor 3 complexes; involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH" /db_xref="GeneID:855981" /db_xref="SGD:S000006043" ORIGIN 1 msdyslkhsv tqyleeipqq vqnrlytspa tclaiyrilp plakffimam vfnenevpll 61 dldkwvnsng klqfqnaiks mkslhllipn kssgtlminl nptfkislrn altggevqns 121 fgvvveenvv sldlldeysa nkwetilhfm vgtplakips ekvlnllkhs klmeevnstg 181 efkitnegfq fllqeinsql wtlllqylkm ietskmdlvd vlhfifmlga levgkaykid 241 alsetqriml qdmrdyglvf qkhsndsify ptklalmlts dtktirsasn amdsvlrqnr 301 eepsvnedga ngksttditt sddlnkaglk nqdipdgsli vetnfkiysy snsplqiavl 361 slfvhlkarf vnmvlgqitr esirraltng itadqiiayl ethahpqmrr laeeklekkl 421 eldpnckepl qvlpptvvdq irlwqleldr vityegslys dfetsqeynl lskyaqdigv 481 llwkddkkkk ffiskegnsq vldfakrklk kkq // LOCUS NP_015204 222 aa linear PLN 30-JUN-2025 DEFINITION Mei5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015204 VERSION NP_015204.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183935.1 REFERENCE 1 (residues 1 to 222) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 222) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 222) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 222) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 222) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11312. Method: conceptual translation. FEATURES Location/Qualifiers source 1..222 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..222 /product="Mei5p" /calculated_mol_wt="26330" Region 15..222 /region_name="Mei5" /note="Double-strand recombination repair protein; pfam10376" /db_xref="CDD:431242" CDS 1..222 /gene="MEI5" /locus_tag="YPL121C" /gene_synonym="LPH6" /coded_by="NM_001183935.1:1..669" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:15620352|PMID:15579681]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0000707 meiotic DNA recombinase assembly [PMID:15620352|PMID:15579681]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:15579681|PMID:15620352]" /note="Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p" /db_xref="GeneID:855982" /db_xref="SGD:S000006042" ORIGIN 1 mhnqeewldk dktlvneeen tcinhsytkk dtnnyrvgks gikdlkkptn qkeiaiknre 61 ltkqltllrq ennhlqqack ilsenkiien rksiekwrti cemelsfiln stlikinrmg 121 gykdflekem eakkrrleyq idngmedqic eikesddfrq lsevekqewe sqmneqlkel 181 ekkkiaelek lnkvlhdseg kdfgmaelct rlkldyslif pq // LOCUS NP_015205 557 aa linear PLN 30-JUN-2025 DEFINITION beclin 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015205 VERSION NP_015205.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183934.1 REFERENCE 1 (residues 1 to 557) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 557) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 557) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 557) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11313. Method: conceptual translation. FEATURES Location/Qualifiers source 1..557 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..557 /product="beclin 1" /calculated_mol_wt="63130" Region 180..314 /region_name="APG6_N" /note="Apg6 coiled-coil region; pfam17675" /db_xref="CDD:465452" Region 320..535 /region_name="APG6" /note="Apg6 BARA domain; pfam04111" /db_xref="CDD:461178" CDS 1..557 /gene="VPS30" /locus_tag="YPL120W" /gene_synonym="APG6; ATG6; VPT30" /coded_by="NM_001183934.1:1..1674" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9105038]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I [PMID:11157979]" /experiment="EXISTENCE:direct assay:GO:0034272 phosphatidylinositol 3-kinase complex, class III, type II [PMID:11157979]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:genetic interaction:GO:0042147 retrograde transport, endosome to Golgi [PMID:12244127]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:21121900]" /experiment="EXISTENCE:mutant phenotype:GO:0006661 phosphatidylinositol biosynthetic process [PMID:12244127]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:22437838]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11157979|PMID:32788210]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:9712845|PMID:9105038]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0042147 retrograde transport, endosome to Golgi [PMID:12244127]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:11157979]" /experiment="EXISTENCE:mutant phenotype:GO:0051365 cellular response to potassium ion starvation [PMID:32788210]" /note="Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant" /db_xref="GeneID:855983" /db_xref="SGD:S000006041" ORIGIN 1 mkcqtchlpl qldpslegls ltqrnlllsn nsiitatnen visnkgieaa dncgpqipke 61 rlrrlgeiqn ikdlnlkddk litdsfvfln hddddnanit snsredqryg nangndnkka 121 nsdtsdgtst frdhdeeeqe atdedenqqi qlnsktlstq vnamtnvfni lssqtnidfp 181 icqdccnili nrlkseydda ikerdtyaqf lsklesqnke isesnkekqy shnlsekenl 241 kkeeerlldq llrlemtddd ldgelvrlqe kkvqlenekl qklsdqnlmd lnniqfnknl 301 qslklqyels lnqldklrki nifnatfkis hsgpfating lrlgsipesv vpwkeinaal 361 gqlilllati nknlkinlvd yelqpmgsfs kikkrmvnsv eynnsttnap gdwlilpvyy 421 denfnlgrif rketkfdksl ettleiisei trqlstiass yssqtlttsq dessmnnand 481 venstsilel pyimnkdkin glsvklhgss pnlewttamk flltnvkwll afssnllsks 541 itlsptvnyn dktisgn // LOCUS NP_878181 87 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL119C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878181 VERSION NP_878181.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184670.1 REFERENCE 1 (residues 1 to 87) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 87) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 87) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 87) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 87) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11314. Method: conceptual translation. FEATURES Location/Qualifiers source 1..87 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..87 /product="uncharacterized protein" /calculated_mol_wt="9981" CDS 1..87 /locus_tag="YPL119C-A" /coded_by="NM_001184670.1:1..264" /note="hypothetical protein; identified by expression profiling and mass spectrometry" /db_xref="GeneID:1466520" /db_xref="SGD:S000028859" ORIGIN 1 mhplvdeltl srylthgtsv lssslysvaf flfffpnflf fcscpnhkwv slpfigmdil 61 ealcfyregk irnifeiggl llqsfyn // LOCUS NP_015206 617 aa linear PLN 30-JUN-2025 DEFINITION putative DEAD-box ATP-dependent RNA helicase DBP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015206 VERSION NP_015206.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183933.1 REFERENCE 1 (residues 1 to 617) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 617) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 617) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 617) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 617) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 617) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 617) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11315. Method: conceptual translation. FEATURES Location/Qualifiers source 1..617 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..617 /product="putative DEAD-box ATP-dependent RNA helicase DBP1" /EC_number="3.6.4.13" /calculated_mol_wt="67786" Region 156..587 /region_name="SrmB" /note="Superfamily II DNA and RNA helicase [Replication, recombination and repair]; COG0513" /db_xref="CDD:440279" CDS 1..617 /gene="DBP1" /locus_tag="YPL119C" /gene_synonym="LPH8" /coded_by="NM_001183933.1:1..1854" /experiment="EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:31299079]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:23222640|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:31299079]" /experiment="EXISTENCE:direct assay:GO:0033677 DNA/RNA helicase activity [PMID:21884706]" /experiment="EXISTENCE:direct assay:GO:0051880 G-quadruplex DNA binding [PMID:30855040]" /experiment="EXISTENCE:direct assay:GO:1901195 positive regulation of formation of translation preinitiation complex [PMID:31299079]" /experiment="EXISTENCE:genetic interaction:GO:0006413 translational initiation [PMID:31299079]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:14763975]" /note="ATP-dependent RNA helicase of the DEAD-box protein family; accelerates eIF4F-dependent assembly of 48S translation preinitiation complex (PIC), stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with DEAD-box RNA helicase and paralog Ded1p, stimulating PIC attachment and highly processive scanning by the 40S ribosomal subunit; binds G-quadruplex (G4) DNA; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:855984" /db_xref="SGD:S000006040" ORIGIN 1 madlpqkvsn lsinnkengg gggkssyvpp hlrsrgkpsf erstpkqedk vtggdffrra 61 grqtgnnggf fgfskerngg tsanynrggs snykssgnrw vngkhipgpk nakleaelfg 121 vhddpdyhss gikfdnydni pvdasgkdvp epildfsspp ldellmenik lasftkptpv 181 qkysipivtk grdlmacaqt gsgktggflf plftelfrsg pspvpekaqs fysrkgypsa 241 lvlaptrela tqifeearkf tyrswvrpcv vyggapignq mrevdrgcdl lvatpgrlnd 301 llergkvsla nikylvldea drmldmgfep qirhiveecd mpsvenrqtl mfsatfpvdi 361 qhlardfldn yiflsvgrvg stsenitqri lyvddmdkks alldllsaeh kgltlifvet 421 krmadqltdf limqnfkata ihgdrtqaer eralsafkan vadilvatav aargldipnv 481 thvinydlps diddyvhrig rtgragntgv atsffnsnnq nivkglmeil neanqevptf 541 lsdlsrqnsr ggrtrggggf fnsrnngsrd yrkhggngsf gstrprntgt snwgsigggf 601 rndnekngyg nsnasww // LOCUS NP_015207 344 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein bS1m MRP51 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015207 VERSION NP_015207.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183932.1 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11316. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..344 /product="mitochondrial 37S ribosomal protein bS1m MRP51" /calculated_mol_wt="39314" Region 3..296 /region_name="Mit_ribos_Mrp51" /note="Mitochondrial ribosomal protein subunit; pfam11709" /db_xref="CDD:463327" CDS 1..344 /gene="MRP51" /locus_tag="YPL118W" /gene_synonym="bS1m" /coded_by="NM_001183932.1:1..1035" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:9528754|PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:9528754|PMID:11278769]" /experiment="EXISTENCE:genetic interaction:GO:0070124 mitochondrial translational initiation [PMID:9528754]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:9528754]" /note="Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences" /db_xref="GeneID:855985" /db_xref="SGD:S000006039" ORIGIN 1 mtlaellgrs riaqvannhk pltytgkkfh pthqiietkp stlyrqewgl ksaipskiks 61 rylvyndldt lerittfepr ggtqwnrlrf qemgvpivsn igrqnpffky isrpedesha 121 klslfkemkg dtdispaamk krlkkitali rsfqdefkew lvenhpdelk lnsnkledyv 181 vkflnkklet ktnkkfntei igtgglsysl pgklknspng viqrtvvpgr ilnvvkennd 241 nkwlaaiggf vadvvffqsp pssfnsmgdf irmktflfei leasmekngs vsmharllep 301 qndktreffn krpiykplts rrarrpsvgn iqeannllni ikgn // LOCUS NP_015208 288 aa linear PLN 30-JUN-2025 DEFINITION isopentenyl-diphosphate delta-isomerase IDI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015208 VERSION NP_015208.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183931.1 REFERENCE 1 (residues 1 to 288) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 288) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 288) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 288) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11317. Method: conceptual translation. FEATURES Location/Qualifiers source 1..288 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..288 /product="isopentenyl-diphosphate delta-isomerase IDI1" /EC_number="5.3.3.2" /calculated_mol_wt="33221" Region 54..288 /region_name="NUDIX_Hydrolase" /note="NUDIX hydrolase superfamily; cl00447" /db_xref="CDD:469772" CDS 1..288 /gene="IDI1" /locus_tag="YPL117C" /gene_synonym="BOT2; LPH10" /coded_by="NM_001183931.1:1..867" /experiment="EXISTENCE:direct assay:GO:0004452 isopentenyl-diphosphate delta-isomerase activity [PMID:2681212]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:2681212]" /experiment="EXISTENCE:direct assay:GO:0045337 farnesyl diphosphate biosynthetic process [PMID:7858969]" /note="Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase" /db_xref="GeneID:855986" /db_xref="SGD:S000006038" ORIGIN 1 mtadnnsmph gavssyaklv qnqtpedile efpeiiplqq rpntrssets ndesgetcfs 61 ghdeeqiklm nencivldwd dnaigagtkk vchlmeniek gllhrafsvf ifneqgelll 121 qqratekitf pdlwtntccs hplciddelg lkgklddkik gaitaavrkl dhelgipede 181 tktrgkfhfl nrihymapsn epwgeheidy ilfykinake nltvnpnvne vrdfkwvspn 241 dlktmfadps ykftpwfkii cenylfnwwe qlddlseven drqihrml // LOCUS NP_015209 697 aa linear PLN 30-JUN-2025 DEFINITION histone deacetylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015209 VERSION NP_015209.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183930.1 REFERENCE 1 (residues 1 to 697) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 697) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 697) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 697) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 697) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 697) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 697) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11318. Method: conceptual translation. FEATURES Location/Qualifiers source 1..697 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..697 /product="histone deacetylase" /EC_number="3.5.1.98" /calculated_mol_wt="79069" Region 47..435 /region_name="HDAC_Hos3" /note="Class II histone deacetylases Hos3 and related proteins; cd09998" /db_xref="CDD:212522" Site order(195..196,204..205,233,235,370,416) /site_type="active" /note="putative active site [active]" /db_xref="CDD:212522" CDS 1..697 /gene="HOS3" /locus_tag="YPL116W" /coded_by="NM_001183930.1:1..2094" /experiment="EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:10535926]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17706600]" /experiment="EXISTENCE:physical interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /note="Trichostatin A-insensitive homodimeric histone deacetylase (HDAC); specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats" /db_xref="GeneID:855987" /db_xref="SGD:S000006037" ORIGIN 1 msskhsdple rfykqfqafv qnnpnvisaa raaaqipesa kavvvlspys lqhvfprewv 61 tksyrktive rperllassm gisaaitmyp slftlksshq rkgslmaphv lkvhgsswpa 121 elielcqmad akllkgeiev pdtwnsgdiy lssktikalq gtigaietgv dsifkgpsae 181 hisnrafvai rppghhchyg tpsgfcllnn ahvaieyayd tynvthvvvl dfdlhhgdgt 241 qdicwkragf kpeeepedss yddfgkkfae fpkvgyfsmh dinsfptesg fatkenikna 301 stcimnshdl niwnihlskw tteeefnvly rtkyrtlfak adeffrsakl emnqqgrpfk 361 glvvisagfd asefeqtsmq rhsvnvptsf yttftkdalk laqmhchgkv lslmeggysd 421 kaicsgvfah liglqnqdwv kewgseqvvk eivrgckpaw kpyktkrakd viriwaeevi 481 rlgramipef ddiifkdavn sapsnsllka tvepaststi aqriirshrs naspekelhe 541 nkprstekqe qreirsdtkv kqlssnnraa etqipflqqe fssededeey vydeelnktf 601 nrtveditid disrhletle iekkgdedsd helkeknwkn shqrrlqgng mykipsntkp 661 hrirqpqnan tptyddsdis mishvsrkht trsggrw // LOCUS NP_015210 1128 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein BEM3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015210 VERSION NP_015210.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183929.1 REFERENCE 1 (residues 1 to 1128) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1128) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1128) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1128) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1128) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11319. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1128 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1128 /product="GTPase-activating protein BEM3" /calculated_mol_wt="124783" Region 520..622 /region_name="PX" /note="PhoX homologous domain, present in p47phox and p40phox; smart00312" /db_xref="CDD:214610" Region 633..741 /region_name="PH_Bem3" /note="Bud emergence protein 3 (Bem3) Pleckstrin homology (PH) domain; cd13277" /db_xref="CDD:270096" Region 904..1110 /region_name="RhoGAP" /note="GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to...; cl02570" /db_xref="CDD:470621" Site order(950,1003,1007,1080,1083..1084,1100) /site_type="other" /note="GTPase interaction site" /db_xref="CDD:239865" Site 950 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:239865" CDS 1..1128 /gene="BEM3" /locus_tag="YPL115C" /coded_by="NM_001183929.1:1..3387" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:12455995|PMID:8300560|PMID:8227021|PMID:7498791]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:17914457]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:11557775]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807|PMID:17914457]" /experiment="EXISTENCE:genetic interaction:GO:0005096 GTPase activator activity [PMID:7498791]" /experiment="EXISTENCE:genetic interaction:GO:0031106 septin ring organization [PMID:14517318]" /experiment="EXISTENCE:genetic interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:17914457]" /experiment="EXISTENCE:mutant phenotype:GO:0030010 establishment of cell polarity [PMID:8013906]" /experiment="EXISTENCE:mutant phenotype:GO:0035024 negative regulation of Rho protein signal transduction [PMID:17914457]" /experiment="EXISTENCE:physical interaction:GO:0035024 negative regulation of Rho protein signal transduction [PMID:17914457]" /note="Rho GTPase activating protein (RhoGAP); involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly" /db_xref="GeneID:855988" /db_xref="SGD:S000006036" ORIGIN 1 mtdnlttthg gsttlellaq yndhrskkdk siehiekgtc sgkernpsyd eifteniklk 61 lqvqeyetei eslekvidml qknreaslev vleqvqndsr dsyvndqsfv lpprsaerka 121 hikslnlpip tlspplqqgs dvaletsvtp tvpqigvtsn tsisrkhlqn milndeiean 181 ssfsspkiin rsvssptkih seqlaspaas vtyttsriti kspnkgsksp lqerlrspqn 241 pnrmtavinn hlhsplkast snnldeltes ksqqltndai qkndrvyssi tssayttgtp 301 tsaakspssl levkegenka lgfspaskek lddftqllds sfgeedlvnt dskdplsiks 361 tineslpppp apptffspts sgniknstpl sshlaspvil nkkddnfgaq saknlkkpvl 421 tsslpnlstk lsttsqnasl ppnppvesss kqkqlgetas ihstntlntf sstpqgslkt 481 lrrphassvs tvksvaqslk sdiplfvqpe dfgtiqievl stlyrdnedd lsiliaiidr 541 ksgkemfkfs ksihkvreld vymkshvpdl plptlpdrql fqtlsptkvd trknilnqyy 601 tsifsvpefp knvglkiaqf istdtvmtpp mmddnvkdgs lllrrpktlt gnstwrvryg 661 ilrddvlqlf dknqltetik lrqssielip nlpedrfgtr ngflitehkk sglststkyy 721 ictetskere lwlsafsdyi dpsqslslss srnandtdsa shlsagthhs kfgnatisat 781 dtpsyvtdlt qeynnnnnis nssnniansd gidsnpsshs nflasssgna eeekdsrrak 841 mrslfpfkkl tgpasamnhi gitisndsds ptspdsiiks pskklmevss ssnsstgphv 901 staifgssle tclrlsshky qnvydlpsvv yrcleylykn rgiqeegifr lsgsstvikt 961 lqerfdkeyd vdlcrynesi eakddeasps lyigvntvsg llklylrklp hllfgdeqfl 1021 sfkrvvdenh nnpvqislgf keliesglvp hanlslmyal fellvrinen skfnkmnlrn 1081 lcivfsptln ipismlqpfi tdfacifqgg epvkeeerek vdihipqv // LOCUS NP_015212 396 aa linear PLN 30-JUN-2025 DEFINITION glyoxylate reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015212 VERSION NP_015212.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183927.1 REFERENCE 1 (residues 1 to 396) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 396) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 396) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 396) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 396) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11320. Method: conceptual translation. FEATURES Location/Qualifiers source 1..396 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..396 /product="glyoxylate reductase" /calculated_mol_wt="44883" Region 15..389 /region_name="Mand_dh_like" /note="D-Mandelate Dehydrogenase-like dehydrogenases; cd12168" /db_xref="CDD:240645" Site order(98..100,123,313,361) /site_type="other" /note="putative ligand binding site [chemical binding]" /db_xref="CDD:240645" Site order(125..126,129,133,136..137,140,142..143,188,190, 193..194,197,200,214..216,218,234..235,239..240,339, 342..344,351,353,356..363,366..368,370) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:240645" Site order(127,225..228,248..249,283..287,290,311..313,337,361, 363..364) /site_type="other" /note="NAD binding site [chemical binding]" /db_xref="CDD:240645" CDS 1..396 /locus_tag="YPL113C" /coded_by="NM_001183927.1:1..1191" /experiment="EXISTENCE:mutant phenotype:GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [PMID:17173333]" /note="Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene" /db_xref="GeneID:855990" /db_xref="SGD:S000006034" ORIGIN 1 mitsidiadv tysakprilv pyktqwevas hlpeyrklae rvefykyems tkddfvkfle 61 thringfwlt eefftvlgnp ssyieffpas lkvilvpwvg cdfidgkllr skgitlcnig 121 phaadhvtel aiflaiscfr mtsfweycfk yvengnveqc kkyissdsye ivtdsyhgqe 181 mkfpsrtdkc kpnkdrkvvh laekytvggk kmespmnkkv lilgfgsigq nigsnlhkvf 241 nmsieyykrt gpvqkslldy nakyhsdldd pntwknadli ilalpstast nniinrksla 301 wckdgvrivn vgrgtcided vlldalesgk vascgldvfk neetrvkqel lrrwdvtalp 361 higstvadmv ikqtlitlen vqdifveggd gkyvln // LOCUS NP_015213 394 aa linear PLN 30-JUN-2025 DEFINITION Pex25p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015213 VERSION NP_015213.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183926.1 REFERENCE 1 (residues 1 to 394) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 394) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 394) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 394) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 394) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11321. Method: conceptual translation. FEATURES Location/Qualifiers source 1..394 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..394 /product="Pex25p" /calculated_mol_wt="44780" CDS 1..394 /gene="PEX25" /locus_tag="YPL112C" /coded_by="NM_001183926.1:1..1185" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:12135984]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:12135984]" /experiment="EXISTENCE:mutant phenotype:GO:0016558 protein import into peroxisome matrix [PMID:12135984]" /note="Peripheral peroxisomal membrane peroxin; required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with Pex27p; PEX25 has a paralog, PEX27, that arose from the whole genome duplication" /db_xref="GeneID:855991" /db_xref="SGD:S000006033" ORIGIN 1 msqfgttdiv sgsetppysg asyqdaqddn thphssdaga ekfsagsgse shtessrsdd 61 edsqaktkmv dnitilkyil dslsgrdkla kiikyaldil klfiekskrn ltvldpsvlt 121 yytkilknlt vkvalrhpit vikvlllsll rnfdkkidfi sqqlstfryi lrfggtpfrv 181 csflgkfnkt rkcnfqidqi kkiwfneasl refldlyygi fdeldllykl kiwtnksfys 241 fvsrqeslaw qydillslkd hwlnlqslqk rqlelevqlk vqnnalllsp ilmhqahkdd 301 gsqspirkql lndlnvnnda evlihkqlka ikdektlvyl diarlsfdcm antsdilnlk 361 tpkgtyavls lgsgltglvk lwittkrslc sskd // LOCUS NP_015214 333 aa linear PLN 30-JUN-2025 DEFINITION arginase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015214 VERSION NP_015214.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183925.1 REFERENCE 1 (residues 1 to 333) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 333) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 333) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 333) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 333) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11322. Method: conceptual translation. FEATURES Location/Qualifiers source 1..333 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..333 /product="arginase" /EC_number="3.5.3.1" /calculated_mol_wt="35531" Region 16..333 /region_name="rocF_arginase" /note="arginase; TIGR01229" /db_xref="CDD:162262" Site order(123,146,148,150,152,163..164,205,208,256,258,301) /site_type="active" /db_xref="CDD:212515" Site order(202,204,209,212..213,221..223,225..228,231..232,235, 273..280,286) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:212515" CDS 1..333 /gene="CAR1" /locus_tag="YPL111W" /gene_synonym="LPH15" /coded_by="NM_001183925.1:1..1002" /experiment="EXISTENCE:direct assay:GO:0000050 urea cycle [PMID:2404017]" /experiment="EXISTENCE:direct assay:GO:0004053 arginase activity [PMID:2404017]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:205532]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:1939179]" /experiment="EXISTENCE:direct assay:GO:0030145 manganese ion binding [PMID:1939179]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0090368 regulation of ornithine metabolic process [PMID:12679340]" /experiment="EXISTENCE:direct assay:GO:0090369 ornithine carbamoyltransferase inhibitor activity [PMID:12679340]" /experiment="EXISTENCE:mutant phenotype:GO:0000050 urea cycle [PMID:14582193]" /experiment="EXISTENCE:mutant phenotype:GO:0004053 arginase activity [PMID:14582193]" /experiment="EXISTENCE:mutant phenotype:GO:0090368 regulation of ornithine metabolic process [PMID:12679340]" /experiment="EXISTENCE:mutant phenotype:GO:0090369 ornithine carbamoyltransferase inhibitor activity [PMID:12679340]" /note="Arginase, catabolizes arginine to ornithine and urea; expression responds to both induction by arginine and nitrogen catabolite repression; disruption decreases production of carcinogen ethyl carbamate during wine fermentation and also enhances freeze tolerance" /db_xref="GeneID:855993" /db_xref="SGD:S000006032" ORIGIN 1 metgphynyy knrelsivla pfsggqgklg vekgpkymlk hglqtsiedl gwstelepsm 61 deaqfvgklk mekdsttggs svmidgvkak radlvgeatk lvynsvskvv qanrfpltlg 121 gdhsiaigtv savldkypda gllwidahad intiestpsg nlhgcpvsfl mglnkdvphc 181 peslkwvpgn lspkkiayig lrdvdagekk ilkdlgiaaf smyhvdkygi naviemamka 241 vhpetngegp imcsydvdgv dplyipatgt pvrggltlre glflverlae sgnlialdvv 301 ecnpdlaihd ihvsntisag caiarcalge tll // LOCUS NP_015215 1223 aa linear PLN 30-JUN-2025 DEFINITION glycerophosphocholine phosphodiesterase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015215 VERSION NP_015215.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183924.1 REFERENCE 1 (residues 1 to 1223) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1223) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1223) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1223) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1223) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11323. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1223 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1223 /product="glycerophosphocholine phosphodiesterase" /EC_number="3.1.4.2" /calculated_mol_wt="137884" Region 1..300 /region_name="COG5408" /note="SPX domain-containing protein [Signal transduction mechanisms]" /db_xref="CDD:227695" Region 409..634 /region_name="ANKYR" /note="Ankyrin repeat [Signal transduction mechanisms]; COG0666" /db_xref="CDD:440430" Region 427..466 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 468..501 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 506..535 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Site order(540,544..545,548..550,552..553,557,560,569,572,574, 578..579,582..584,586..587,591,594,603,605,607,611..612, 615..617,619..620,624,629) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:293786" Region 540..569 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 572..603 /region_name="ANK repeat" /note="ANK repeat [structural motif]" /db_xref="CDD:293786" Region 871..1219 /region_name="GDPD_YPL110cp_fungi" /note="Glycerophosphodiester phosphodiesterase domain of Saccharomyces cerevisiae YPL110cp and similar proteins; cd08606" /db_xref="CDD:176548" Site order(877,911,913,926,1060,1104,1184) /site_type="active" /note="putative active site [active]" /db_xref="CDD:176548" Site order(877,926) /site_type="active" /note="catalytic site [active]" /db_xref="CDD:176548" Site order(911,913,1060) /site_type="other" /note="putative metal binding site [ion binding]" /db_xref="CDD:176548" CDS 1..1223 /gene="GDE1" /locus_tag="YPL110C" /coded_by="NM_001183924.1:1..3672" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0046475 glycerophospholipid catabolic process [PMID:16141200]" /experiment="EXISTENCE:mutant phenotype:GO:0047389 glycerophosphocholine phosphodiesterase activity [PMID:16141200]" /note="Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes" /db_xref="GeneID:855994" /db_xref="SGD:S000006031" ORIGIN 1 mkfgktfanh ripewssqyv gykslkkmik eitrlqediy rahnknsyde grpptkmrds 61 snsaqnylds pkiqkllasf ffavdrdiek vdtfynsqya eykkrferll ssnqfneiks 121 tlvvdanked avaqtlltkd tremnmllkg tsqasrlsyh kddlieiqsi laelrkqfrn 181 lkwyaelnkr afgkilkkld kkvgtnqqms tmktrilplq fandslitkd lsllktiweq 241 vtfrinsyer vmrstspnan andnteffki icvfieedds kglireltnl yselsliptr 301 imisvlnkaa lskslacida ilkvipslnd sedinrrnff hhhiiaigkl irkqeilsrk 361 kksqpskytn segeivtdlr tlhttlsapa esdsiteeek ssactlsyil eelpihlrpc 421 lfqhdnykrt plhyscqygl sevtkliikl mkewniwnei piddvsafgd aesltplhlc 481 vlgahpktte vllqsldpnv klksssllhl atewnnypll hvllsskrfd inyqdnelhe 541 tplylacrln ffeaavclly ngadleirek lfgwtaifva aaegftdivk lliannanfd 601 iedeggwtpm ehavlrghlh iadmvqirde lvthphsqln sgseekepln eisagelner 661 nengnggnkg slgklagpik syghrfldnn eslilitlgs ndtrnkspsi slssealakv 721 igletdcals lviscndsid kssvildlpl ddnvdavdfk vpfkvdysht lyfdivptyg 781 trslethnri dcqknnnnyv margvsmlnk syssvgvnrs ilngsvtvpi ianhtleilg 841 tlkfeyiiit pfehpqlple rtetywkslv strvighrgl gknnpnkslq igentvesfi 901 maaslgasyv efdvqltkdn vpvvyhdflv aetgvdipmh eltleqfldl nnadkehiqr 961 gaghsphhvn gadtalqkyr grsvddsdvs tlrrawdlhd ndpngksnna hwsdnrmrlt 1021 ktfkknnfkg narghsiass fvtlkelfkk ipanvgfnie ckfpmldeae eeelgqimme 1081 mnhwvdtvlk vvfdnangrd iifssfhpdi cimlslkqpv ipilfltegg seqmadlras 1141 slqngirfak kwnllgivsa aapilkaprl vqvvksnglv cvtygvdnnd penasiqiea 1201 gvdavivdsv lairrgltkk nek // LOCUS NP_015216 657 aa linear PLN 30-JUN-2025 DEFINITION Cqd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015216 VERSION NP_015216.3 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183923.1 REFERENCE 1 (residues 1 to 657) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 657) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 657) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 657) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11324. On Jul 26, 2004 this sequence version replaced NP_015216.2. Method: conceptual translation. FEATURES Location/Qualifiers source 1..657 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..657 /product="Cqd1p" /calculated_mol_wt="76046" Region 200..538 /region_name="ADCK2-like" /note="aarF domain containing kinase 2 and similar proteins; cd13971" /db_xref="CDD:270873" Site order(251..254,270,272,282,284,345,364..367,412,416..417, 419,476..477) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:270873" CDS 1..657 /gene="CQD1" /locus_tag="YPL109C" /gene_synonym="MCO76" /coded_by="NM_001183923.1:1..1974" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:37073556]" /experiment="EXISTENCE:direct assay:GO:0044289 mitochondrial inner-outer membrane contact site [PMID:37073556]" /experiment="EXISTENCE:genetic interaction:GO:0007005 mitochondrion organization [PMID:37073556]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:37073556]" /experiment="EXISTENCE:mutant phenotype:GO:0055091 phospholipid homeostasis [PMID:37073556]" /note="UbiB protein kinase-like family member; mitochondrial inner membrane protein that interacts with outer membrane proteins Por1p and Om14p to form a MICOS-independent mitochondrial contact site; role in mitochondrial organization; contributes to mitochondrial lipid homeostasis; controls the cellular distribution of coenzyme Q (CoQ); contains a potential mitochondrial targeting sequence and predicted transmembrane domain" /db_xref="GeneID:855995" /db_xref="SGD:S000006030" ORIGIN 1 msflkfayrn swryyskstr hfhkipirqf iiptsiafyl tqnsfpkqnc liyndslkpd 61 pkgdtfemgl yvssenelqe klksfrsaki tesrnkliry lrifwfgfnd nivepvctil 121 rfleisaifl pllllypisw fghklkitdt nitetrgsli wcqllrkale lagpsfiklg 181 qwagsrtdif shalchelgk lhsnvtahsl sftleklsqa lkvdkiedaf defnrtpigv 241 gsiaqvyvge lsqkyidkyd niqigkdgnr wcaikilhpn vrsqirrdlk imkfcadain 301 wiptmewlsl psevdqfsil mniqldlrie alnlerfnen fknsiqvkfp kpflplsnrd 361 vmfeehvygl smekflstkk qindvelckk vsdpfvdafl qmlilddfvh adlhpgnvii 421 rfvktnkygt niisselesy rithdlrkki eedqdqdfvg klksvltnyt pqicfidtgi 481 itelneknri nfialfnala rfdgyragel miersrtpet aidkevfafk veklvdkvkq 541 rtftlgtvsi gdlldqmlsm vrshhvrmes dfvsvvvail llegigrqld pnldlfessl 601 pilrefgfkr eaksllkdas tlsmlkiwvg levrqlmhls mkqiydlvrt dqlcpny // LOCUS NP_015217 168 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL108W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015217 VERSION NP_015217.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183922.1 REFERENCE 1 (residues 1 to 168) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 168) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 168) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 168) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 168) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11325. Method: conceptual translation. FEATURES Location/Qualifiers source 1..168 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..168 /product="uncharacterized protein" /calculated_mol_wt="19688" CDS 1..168 /locus_tag="YPL108W" /coded_by="NM_001183922.1:1..507" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Cytoplasmic hypothetical protein; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:855996" /db_xref="SGD:S000006029" ORIGIN 1 mkeasdreea pkmveknyst gfrkahgekd qsvtkpisld grtgevivrk stgktkirkg 61 qteeeytqql qhyfeveqgp vrtkvgwmde vdplveireg kydisnkhqr qvlsgfchrl 121 fyqckykecl dlstyflglf epfnvknkmk releeleymi ercrghvl // LOCUS NP_015218 248 aa linear PLN 30-JUN-2025 DEFINITION Dpc25p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015218 VERSION NP_015218.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183921.1 REFERENCE 1 (residues 1 to 248) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 248) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 248) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 248) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 248) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11326. Method: conceptual translation. FEATURES Location/Qualifiers source 1..248 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..248 /product="Dpc25p" /calculated_mol_wt="28439" Region 71..114 /region_name="Oxidored-like" /note="Oxidoreductase-like protein, N-terminal; pfam09791" /db_xref="CDD:462904" CDS 1..248 /gene="DPC25" /locus_tag="YPL107W" /coded_by="NM_001183921.1:1..747" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /note="Putative mitochondrial hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; DPC25 is not an essential gene" /db_xref="GeneID:855997" /db_xref="SGD:S000006028" ORIGIN 1 mirnqgwsll yriypvrrft rysrvdmtfe gntqdistsv eermttvfgg rlkgepprst 61 srvlsggtkk iagvqvpakp qepdnccmsg cvncvweiys edlrdwkhrr keaaekiagt 121 kekwpkdwnp plgllhmenv pvelrekkle tdskkaeqph dlsairslfp krkgplpksv 181 laakrknial rhnyeqkdgg dqsvsesdad egwedipvyv kafaefeskk rlqkirrqee 241 ikkrtalv // LOCUS NP_015219 693 aa linear PLN 30-JUN-2025 DEFINITION adenyl-nucleotide exchange factor SSE1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015219 VERSION NP_015219.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183920.1 REFERENCE 1 (residues 1 to 693) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 693) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 693) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 693) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 693) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11327. Method: conceptual translation. FEATURES Location/Qualifiers source 1..693 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..693 /product="adenyl-nucleotide exchange factor SSE1" /calculated_mol_wt="77236" Region 4..644 /region_name="ASKHA_ATPase-like" /note="ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; cl49607" /db_xref="CDD:483947" CDS 1..693 /gene="SSE1" /locus_tag="YPL106C" /gene_synonym="LPG3; MSI3" /coded_by="NM_001183920.1:1..2082" /experiment="EXISTENCE:direct assay:GO:0000774 adenyl-nucleotide exchange factor activity [PMID:17154545|PMID:16688212]" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:17154545|PMID:15028727]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0042026 protein refolding [PMID:16688212]" /experiment="EXISTENCE:direct assay:GO:0042277 peptide binding [PMID:18539149]" /experiment="EXISTENCE:genetic interaction:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:29507114]" /experiment="EXISTENCE:genetic interaction:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:29507114]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:15028727]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:10480867]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:31962153]" /note="ATPase component of heat shock protein Hsp90 chaperone complex; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; plays a role in prion propagation and determining prion variants; binds unfolded proteins; member of Hsp110 subclass of HSP70 proteins; deletion results in spindle elongation in S phase; SSE1 has a paralog, SSE2, that arose from the whole genome duplication" /db_xref="GeneID:855998" /db_xref="SGD:S000006027" ORIGIN 1 mstpfgldlg nnnsvlavar nrgidivvne vsnrstpsvv gfgpknrylg etgknkqtsn 61 ikntvanlkr iigldyhhpd feqeskhfts klvelddkkt gaevrfagek hvfsatqlaa 121 mfidkvkdtv kqdtkanitd vciavppwyt eeqryniada ariaglnpvr ivndvtaagv 181 sygifktdlp egeekpriva fvdighssyt csimafkkgq lkvlgtacdk hfggrdfdla 241 itehfadefk tkykidiren pkaynrilta aeklkkvlsa ntnapfsves vmndvdvssq 301 lsreeleelv kpllervtep vtkalaqakl saeevdfvei iggttriptl kqsiseafgk 361 plsttlnqde aiakgaafic aihsptlrvr pfkfedihpy svsyswdkqv ededhmevfp 421 agssfpstkl itlnrtgdfs maasytditq lppntpeqia nweitgvqlp egqdsvpvkl 481 klrcdpsglh tieeaytied ieveepiplp edapedaeqe fkkvtktvkk ddltivahtf 541 gldakklnel iekenemlaq dklvaetedr kntleeyiyt lrgkleeeya pfasdaektk 601 lqgmlnkaee wlydegfdsi kakyiakyee laslgniirg rylakeeekk qairskqeas 661 qmaamaekla aqrkaeaekk eekkdtegdv dmd // LOCUS NP_015220 849 aa linear PLN 30-JUN-2025 DEFINITION Syh1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015220 VERSION NP_015220.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183919.1 REFERENCE 1 (residues 1 to 849) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 849) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 849) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 849) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 849) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11328. Method: conceptual translation. FEATURES Location/Qualifiers source 1..849 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..849 /product="Syh1p" /calculated_mol_wt="94226" Region 149..205 /region_name="GYF" /note="GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species; cd00072" /db_xref="CDD:238027" Site 163..179 /site_type="active" /note="proline binding motif [active]" /db_xref="CDD:238027" Site order(173,178..179) /site_type="active" /note="proline interaction residues [active]" /db_xref="CDD:238027" CDS 1..849 /gene="SYH1" /locus_tag="YPL105C" /gene_synonym="MYR1" /coded_by="NM_001183919.1:1..2550" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:18327588]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0051664 nuclear pore localization [PMID:18327588]" /note="hypothetical protein that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan; SYH1 has a paralog, SMY2, that arose from the whole genome duplication" /db_xref="GeneID:855999" /db_xref="SGD:S000006026" ORIGIN 1 mnpinslafd lhsvkladan sdtaalsnsn tptmnnaall qrpssimdsi gvqrvpspfv 61 pgsnaisgas tvpfnaydae itgsplqisa nqennsafsa assnlhmnas spsvlnkpss 121 tfpnvapyly natgpapnvg nqppppgies qwkyidsngn iqgpfgtnnm sqwyqggyft 181 ptlqicrlat spepfgvndr firlgelttl vnnyqdpfva fdfiviraln avplvaptss 241 ekqkvesrdl ipvadvhsdd ftyeeilglk fedgsyyhet qvwvpvdgrh itkvdripki 301 saytaplstt ssrsnkttss heekvpshee aspeeqevfs eegrtvsnit neeesivknp 361 tkqeeesrgs ekeqnildqv qpeieevdrk dvistadepk skdtpqmtse eqkrfakael 421 maqklleeqq rqeeekkrre eqrklkkekk lkqkqkkeee klkkkkkeeg klekekqkel 481 lnniltgdte tpssentats ittnlapwan kkpegavynq issaledlkk ensskkekkp 541 nrtqldreqa lklqkeilss aqipktqtgs awgikpqqpi kvdikgelmk dstkinsqsk 601 inkanngdik pdstfieeqk klweqvqkkt kkfnrassld dfisrtpsps ssalnssnts 661 nawttvssks tthiastmpv agnqsksyis ldtlrssggl statktkmsd kskqigssts 721 iptlkarqvk psripaypgn asvskrqefl rwcrsqlkln tgvqpdnvle mllslppgse 781 skeiiadtiy sysstmdgrr fatdfikkrl eceeeindpl swsevlampe gssedwefqv 841 vgkkkgkrf // LOCUS NP_015221 658 aa linear PLN 30-JUN-2025 DEFINITION aspartate--tRNA ligase MSD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015221 VERSION NP_015221.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183918.1 REFERENCE 1 (residues 1 to 658) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 658) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 658) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 658) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 658) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 658) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 658) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11329. Method: conceptual translation. FEATURES Location/Qualifiers source 1..658 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..658 /product="aspartate--tRNA ligase MSD1" /EC_number="6.1.1.12" /calculated_mol_wt="75330" Region 35..658 /region_name="aspS_bact" /note="aspartyl-tRNA synthetase, bacterial type; TIGR00459" /db_xref="CDD:211576" CDS 1..658 /gene="MSD1" /locus_tag="YPL104W" /gene_synonym="LPG5" /coded_by="NM_001183918.1:1..1977" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:genetic interaction:GO:0070146 mitochondrial aspartyl-tRNA aminoacylation [PMID:10710420]" /experiment="EXISTENCE:mutant phenotype:GO:0004815 aspartate-tRNA ligase activity [PMID:2668951]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:2668951]" /experiment="EXISTENCE:mutant phenotype:GO:0070146 mitochondrial aspartyl-tRNA aminoacylation [PMID:2668951]" /note="Mitochondrial aspartyl-tRNA synthetase; required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene" /db_xref="GeneID:856000" /db_xref="SGD:S000006025" ORIGIN 1 mlarsrvclq titrrladfp eanaikkkfl frkdtstikq lkglssgqki vlngwieqkp 61 krvgknlifg llrdsngdii qlvdnksllk gftledvvqa vgilslkrkl snedadeyev 121 qleditvlna snkkpaqmqd fklsaiyppe frylqlrnpk yqdflkkrss iskeirnsfn 181 nfdftevetp mlfkatpega reflvptrtk rsdgkpsfya ldqspqqykq llmasgvnky 241 yqmarcfrde dlradrqpef tqvdmemafa nsedvmkiie ktvsgvwskf skkrglltld 301 skgtlvpakk engtvsifrm tyeqamtsyg idkpdlrapd lkiinlgefn afshlnkkfp 361 vfeviilrsa fsnmeeyker wsfltnnsny nyrvpivlpi endeqansnw fenfhaiatf 421 enphlitkfl klkkgdivcg ctrepnhsif enptplgrlr qlvlqsehgk niyhavnkdv 481 aswivdfplf spviiedksg kkeklaypey ekdrlcsthh pftmvklkdy eklektpekc 541 lgrhydlvvn gvelgggstr ihdprlqdyi fedilkidna yelfghllna fdmgtpphag 601 faigfdrmca micetesird viafpksitg adlvvkspsv ipesilepyn ikysnskk // LOCUS NP_015222 468 aa linear PLN 30-JUN-2025 DEFINITION N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D [Saccharomyces cerevisiae S288C]. ACCESSION NP_015222 VERSION NP_015222.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183917.1 REFERENCE 1 (residues 1 to 468) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 468) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 468) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 468) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 468) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11330. Method: conceptual translation. FEATURES Location/Qualifiers source 1..468 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..468 /product="N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D" /EC_number="3.1.4.54" /calculated_mol_wt="54237" Region 209..448 /region_name="UlaG" /note="L-ascorbate lactonase UlaG, metallo-beta-lactamase superfamily [Carbohydrate transport and metabolism]; COG2220" /db_xref="CDD:441822" CDS 1..468 /gene="FMP30" /locus_tag="YPL103C" /coded_by="NM_001183917.1:1..1407" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:21306442]" /experiment="EXISTENCE:mutant phenotype:GO:0070291 N-acylethanolamine metabolic process [PMID:15878693]" /experiment="EXISTENCE:mutant phenotype:GO:0070292 N-acylphosphatidylethanolamine metabolic process [PMID:15878693]" /note="Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D" /db_xref="GeneID:856001" /db_xref="SGD:S000006024" ORIGIN 1 mnfvtchvqm rlllqrrlvr lreselfrpq tslstfkrha sqktrpiqkc srkyarilll 61 svlvpytgya fyvslatvkq idlrnemcqr leennnevty kgsllkyspl evlgrfenpf 121 eeyriqtvfe ffanrvfelf ernrggiprd vhqmnklmpv hkptwgpnlv dvdpaeetal 181 pleckvldel hiptaveene gskcpvyntw lgqscnytvy nglriltdpl fsdflihktl 241 gpkritqmps qitevpkpdi ilvshnhpdh ldlesleyws gkdsplwivp kgmksymtsn 301 gcdnvlelsw wetlqvkknn eiyhisatpa mhwsgrslld tnkslwcsfl lthhgnpilf 361 hagdtgyvkd lfvrikerfg kgcklallpc gqycpewhqk prhinpqevl kimkdlearn 421 vlgvhwgtfv lsgeyflepk eklemlaewg gfkdrcycpe lgktecfd // LOCUS NP_015224 456 aa linear PLN 30-JUN-2025 DEFINITION Elongator subunit ELP4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015224 VERSION NP_015224.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183915.1 REFERENCE 1 (residues 1 to 456) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 456) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 456) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 456) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11331. Method: conceptual translation. FEATURES Location/Qualifiers source 1..456 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..456 /product="Elongator subunit ELP4" /calculated_mol_wt="51025" Region 70..456 /region_name="PAXNEB" /note="PAXNEB protein; pfam05625" /db_xref="CDD:461696" CDS 1..456 /gene="ELP4" /locus_tag="YPL101W" /gene_synonym="HAP1; KTI9; TOT7" /coded_by="NM_001183915.1:1..1371" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:22343726]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:22343726]" /experiment="EXISTENCE:direct assay:GO:0033588 elongator holoenzyme complex [PMID:11689709]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11689709]" /note="Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity; null mutation is functionally complemented by human ELP4" /db_xref="GeneID:856002" /db_xref="SGD:S000006022" ORIGIN 1 msfrkrgeil ndrgsglrgp llrgpprtss tplrtgnrra pgnvplsdtt arlkklniad 61 esktkmglds shvgvrpspa tsqpttstgs adldsilghm glplgnsvlv eeqsttefhs 121 ilgklfaaqg ivhnrisdss adktrngdth vivlslnqmf akelpgiykg srkqmkknli 181 seeeskvtvq nlnetqrstp srykdlkiaw kykladekrl gspdrddiqq nseykdynhq 241 fdittrlmpa piaseltfia ptqpvstils qieqtikrnd kklirivips llhpamyppk 301 mfesseiigl mhgvrslvkk yyervvlfas isidiitppl lvllrnmfds vinlepfnqe 361 mteflervyk sqpgkiqhgl vhilklpvft drgemrvlks ewafkngrkk feieqwgipv 421 ddaegsaase qshshshsde ishnipakkt kisldy // LOCUS NP_015225 496 aa linear PLN 30-JUN-2025 DEFINITION Atg21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015225 VERSION NP_015225.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183914.1 REFERENCE 1 (residues 1 to 496) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 496) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 496) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 496) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 496) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11332. Method: conceptual translation. FEATURES Location/Qualifiers source 1..496 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..496 /product="Atg21p" /calculated_mol_wt="55057" Region <277..>379 /region_name="WD40" /note="WD40 repeat [General function prediction only]; COG2319" /db_xref="CDD:441893" Region 300..343 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 351..385 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 393..447 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 454..478 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..496 /gene="ATG21" /locus_tag="YPL100W" /gene_synonym="HSV1; MAI1" /coded_by="NM_001183914.1:1..1491" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:15194695|PMID:11852075]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:25691244]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:18769150]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:11852075]" /experiment="EXISTENCE:direct assay:GO:0032266 phosphatidylinositol-3-phosphate binding [PMID:15155809|PMID:16876790]" /experiment="EXISTENCE:direct assay:GO:0070273 phosphatidylinositol-4-phosphate binding [PMID:15155809]" /experiment="EXISTENCE:direct assay:GO:0080025 phosphatidylinositol-3,5-bisphosphate binding [PMID:15103325]" /experiment="EXISTENCE:mutant phenotype:GO:0000407 phagophore assembly site [PMID:25691244]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006497 protein lipidation [PMID:15155809]" /experiment="EXISTENCE:mutant phenotype:GO:0016050 vesicle organization [PMID:15155809]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:15194695]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:16876790]" /experiment="EXISTENCE:mutant phenotype:GO:0034497 protein localization to phagophore assembly site [PMID:15155809|PMID:25691244]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /note="Phosphoinositide binding protein; required for vesicle formation in cytoplasm-to-vacuole targeting (CVT) pathway, autophagy, micronucleophagy and mitophagy; binds to several phosphoinositides including PtdIns(3,5)P2, PI3P and PI4P; involved in PI3P-dependent recruitment and organization of both Atg12-Atg5-Atg16 complex and Atg8p at pre-autophagosomal structure; necessary for oxidant-induced cell death; targeted to vacuole via AP-3 pathway; WD-40 repeat containing PROPPIN family member" /db_xref="GeneID:856004" /db_xref="SGD:S000006021" ORIGIN 1 mkvlqfnqda tccvvaassh qisifncdpf gkcfeidtkn skkktsnnng sasnsesrnn 61 eesilitngs rdrtdaeeee dnednalvtg nilkegefvi emlfstslia iadrgqglnk 121 gkklkivntk rkcticeivf pheivdvvmn rkrmcvlles dqifiydisc mkpletidlw 181 edhykrsqan sfsnasntgt legdsanlnr vatnllanat qksvngsnps vrtrrnslrs 241 kirprmvlsn ddrsilcfta ysspkknkpn sealydvviy dtlnvtpvny lnsvhkgnva 301 clavshdgkl latasdkgti irvfhtgvds dymssrslfk efrrgtrlcn lyqlafdksm 361 tmigcvgdtd tihlfkldda snslpgdnss nghwneeeyi lasnsnpsmg tpkeiplskp 421 rianyfskki kssipnqnls rnfayitvne snrsclgfpd efpnqvyias ddgtfsiysi 481 pskpgecvlt knnkft // LOCUS NP_015226 182 aa linear PLN 30-JUN-2025 DEFINITION Ina17p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015226 VERSION NP_015226.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183913.1 REFERENCE 1 (residues 1 to 182) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 182) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 182) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 182) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 182) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11333. Method: conceptual translation. FEATURES Location/Qualifiers source 1..182 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..182 /product="Ina17p" /calculated_mol_wt="21711" CDS 1..182 /gene="INA17" /locus_tag="YPL099C" /gene_synonym="AIM43; FMP14" /coded_by="NM_001183913.1:1..549" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:26928762|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:24942160]" /experiment="EXISTENCE:direct assay:GO:1990524 INA complex [PMID:24942160]" /experiment="EXISTENCE:genetic interaction:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:24942160]" /experiment="EXISTENCE:mutant phenotype:GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly [PMID:24942160]" /experiment="EXISTENCE:physical interaction:GO:1990524 INA complex [PMID:24942160]" /note="F1F0 ATPase synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Ina22p and ATP synthase subunits; null mutant displays elevated frequency of mitochondrial genome loss and has a respiratory growth defect" /db_xref="GeneID:856005" /db_xref="SGD:S000006020" ORIGIN 1 mlkrrsnali tlsrtklfpi ttvayyhrrl lnqqrravst spkkeiksle dlanldsldg 61 vdtelirdli nehttklnik keldmlkkfs qeeesgheip vkrfirplwm filmgssvyl 121 llhfswwkle heeresqlkk eveilehqln elivqdkthn tsrgkgsnes thmkpwyrrw 181 fw // LOCUS NP_015227 113 aa linear PLN 30-JUN-2025 DEFINITION Mgr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015227 VERSION NP_015227.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183912.1 REFERENCE 1 (residues 1 to 113) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 113) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 113) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 113) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 113) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11334. Method: conceptual translation. FEATURES Location/Qualifiers source 1..113 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..113 /product="Mgr2p" /calculated_mol_wt="12121" Region 14..79 /region_name="Romo1" /note="Reactive mitochondrial oxygen species modulator 1; pfam10247" /db_xref="CDD:431168" CDS 1..113 /gene="MGR2" /locus_tag="YPL098C" /coded_by="NM_001183912.1:1..342" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:22613836]" /experiment="EXISTENCE:mutant phenotype:GO:0045039 protein insertion into mitochondrial inner membrane [PMID:25454944]" /experiment="EXISTENCE:physical interaction:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:22613836]" /note="Core component of the TIM23 protein translocase complex; couples Tim21 with the core Tim23 translocase; provides quality control for membrane protein insertion, regulating their release into the inner membrane by the TIM23 complex; required for mitochondrial import of presequence-containing proteins at elevated temperature; forms the translocation path with Tim17p, sealing the lateral opening of the Tim17p cavity; required for viability of cells lacking the mitochondrial genome (petite-negative)" /db_xref="GeneID:856006" /db_xref="SGD:S000006019" ORIGIN 1 mpplpqnyaq qqpsnwdkfk mglmmgttvg vctgilfggf aiatqgpgpd gvvrtlgkyi 61 agsagtfglf msigsiirsd sesspmshpn lnlqqqarle mwklrakygi rkd // LOCUS NP_015228 492 aa linear PLN 30-JUN-2025 DEFINITION tyrosine--tRNA ligase MSY1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015228 VERSION NP_015228.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183911.1 REFERENCE 1 (residues 1 to 492) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 492) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 492) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 492) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11335. Method: conceptual translation. FEATURES Location/Qualifiers source 1..492 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..492 /product="tyrosine--tRNA ligase MSY1" /EC_number="6.1.1.1" /calculated_mol_wt="55156" Region 54..471 /region_name="tyrS" /note="tyrosyl-tRNA synthetase; TIGR00234" /db_xref="CDD:272976" CDS 1..492 /gene="MSY1" /locus_tag="YPL097W" /coded_by="NM_001183911.1:1..1479" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:genetic interaction:GO:0004831 tyrosine-tRNA ligase activity [PMID:3315228]" /experiment="EXISTENCE:genetic interaction:GO:0070184 mitochondrial tyrosyl-tRNA aminoacylation [PMID:3315228]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:3315228]" /note="Mitochondrial tyrosyl-tRNA synthetase" /db_xref="GeneID:856007" /db_xref="SGD:S000006018" ORIGIN 1 mlelrscsnl vnssrrlvpl vtysglsait lpksrfysqp salevqgtsd srsdnildel 61 kqrglvsqvs qpesflrtkl ngndkiklyc gvdptaqslh lgnlvplmvl lhfyvkghdi 121 vtviggatgk vgdpsgrkte rdvmendirq snvasisqql qrffkngley yrnrcalted 181 vpsgkytprn nfnwwkdikm ldfladfgrh irvqsmlard sissrlqtkn glgfneftyq 241 vlqaydfyhl ykeenvtiqv ggndqwgnit agidlinriq piknkglpfg itvpllttat 301 gekfgksagn avfidpsint aydvyqffyn tldadvpkfl kiftflnsse ikkivethik 361 spslrygqtl lakevtdmly gvgsgsdsea lsniifgryd gtlsaaklvd lckkarilqy 421 adreidlikl icklvncsvs earrklsqgs vylhhskskv nenisnlapf liddrvlilr 481 igkqkcfiie mr // LOCUS NP_690846 68 aa linear PLN 30-JUN-2025 DEFINITION Eri1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_690846 VERSION NP_690846.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184515.1 REFERENCE 1 (residues 1 to 68) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 68) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 68) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 68) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 68) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11336. Method: conceptual translation. FEATURES Location/Qualifiers source 1..68 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..68 /product="Eri1p" /calculated_mol_wt="7908" CDS 1..68 /gene="ERI1" /locus_tag="YPL096C-A" /gene_synonym="RIN1" /coded_by="NM_001184515.1:1..207" /experiment="EXISTENCE:direct assay:GO:0005095 GTPase inhibitor activity [PMID:12832483]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:12832483]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:15163411]" /experiment="EXISTENCE:mutant phenotype:GO:0007265 Ras protein signal transduction [PMID:12832483]" /experiment="EXISTENCE:physical interaction:GO:0000506 glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex [PMID:15163411]" /note="Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein" /db_xref="GeneID:856008" /db_xref="SGD:S000028423" ORIGIN 1 mrprdqgflv lgftysvlli slatfywlrn ndsflhywcv lllcpatlwl waliawcdse 61 mfasskde // LOCUS NP_015229 363 aa linear PLN 30-JUN-2025 DEFINITION peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015229 VERSION NP_015229.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183910.1 REFERENCE 1 (residues 1 to 363) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 363) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 363) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 363) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 363) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11337. Method: conceptual translation. FEATURES Location/Qualifiers source 1..363 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..363 /product="peptide-N4-(N-acetyl-beta- glucosaminyl)asparagine amidase" /EC_number="3.5.1.52" /calculated_mol_wt="42354" Region 183..237 /region_name="TGc" /note="Transglutaminase/protease-like homologues; smart00460" /db_xref="CDD:214673" Region <220..>274 /region_name="Rad4" /note="Rad4 transglutaminase-like domain; pfam03835" /db_xref="CDD:427539" CDS 1..363 /gene="PNG1" /locus_tag="YPL096W" /coded_by="NM_001183910.1:1..1092" /experiment="EXISTENCE:direct assay:GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity [PMID:10831608]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10831608]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10831608|PMID:15910746]" /experiment="EXISTENCE:direct assay:GO:0006517 protein deglycosylation [PMID:10831608]" /experiment="EXISTENCE:mutant phenotype:GO:0006515 protein quality control for misfolded or incompletely synthesized proteins [PMID:10831608]" /experiment="EXISTENCE:mutant phenotype:GO:0006517 protein deglycosylation [PMID:25497214|PMID:27433019]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:25497214]" /experiment="EXISTENCE:mutant phenotype:GO:0097466 ubiquitin-dependent glycoprotein ERAD pathway [PMID:27433019]" /note="Conserved peptide N-glycanase; deglycosylating enzyme that cleaves N-glycans that are attached to misfolded ERAD substrate glycoproteins prior to proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p; human ortholog NGLY1 is associated with a syndrome characterized by developmental delays, epilepsy, absence of tears and liver disease" /db_xref="GeneID:856009" /db_xref="SGD:S000006017" ORIGIN 1 mgevyeknni dfdsiakmll ikykdfilsk fkkaapveni rfqnlvhtnq faqgvlgqsq 61 hlctvydnps whsivletld ldliyknvdk efakdghaeg eniytdylvk ellryfkqdf 121 fkwcnkpdcn hcgqntsenm tplgsqgpng eeskfncgtv eiykcnrcgn itrfpryndp 181 iklletrkgr cgewcnlftl ilksfgldvr yvwnredhvw ceyfsnflnr wvhvdsceqs 241 fdqpyiysin wnkkmsycia fgkdgvvdvs kryilqnelp rdqikeedlk flcqfitkrl 301 ryslnddeiy qlacrdeqeq ielirgktqe tksesvsaas kssnrgresg sadwkaqrge 361 dgk // LOCUS NP_015230 456 aa linear PLN 30-JUN-2025 DEFINITION medium-chain fatty acid ethyl ester synthase/esterase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015230 VERSION NP_015230.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183909.1 REFERENCE 1 (residues 1 to 456) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 456) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 456) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 456) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11338. Method: conceptual translation. FEATURES Location/Qualifiers source 1..456 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..456 /product="medium-chain fatty acid ethyl ester synthase/esterase" /EC_number="2.3.1.84" /calculated_mol_wt="51593" Region 59..451 /region_name="YheT" /note="Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; COG0429" /db_xref="CDD:440198" CDS 1..456 /gene="EEB1" /locus_tag="YPL095C" /coded_by="NM_001183909.1:1..1371" /experiment="EXISTENCE:direct assay:GO:0004026 alcohol O-acetyltransferase activity [PMID:16361250]" /experiment="EXISTENCE:direct assay:GO:0034338 short-chain carboxylesterase activity [PMID:16361250]" /experiment="EXISTENCE:direct assay:GO:0051792 medium-chain fatty acid biosynthetic process [PMID:16361250]" /experiment="EXISTENCE:mutant phenotype:GO:0051792 medium-chain fatty acid biosynthetic process [PMID:16361250]" /experiment="EXISTENCE:mutant phenotype:GO:0051793 medium-chain fatty acid catabolic process [PMID:16361250]" /note="Acyl-coenzymeA:ethanol O-acyltransferase; responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification; EEB1 has a paralog, EHT1, that arose from the whole genome duplication" /db_xref="GeneID:856010" /db_xref="SGD:S000006016" ORIGIN 1 mfrsgyyptv tpshwgyngt vkhvlgekgt kslafrdskr qiplhefvtk hvptlkdgan 61 frlnsllftg ylqtlylsag dfskkfqvfy greiikfsdg gvctadwvmp eweqtyslna 121 ekasfnekqf sndekathpk gwprlhprtr ylsseelekc hskgysyplv vvlhglaggs 181 hepliralse dlskvgdgkf qvvvlnargc srskvttrri ftalhtgdvr eflnhqkalf 241 pqrkiyavgt sfgaamltny lgeegdncpl naavalsnpw dfvhtwdkla hdwwsnhifs 301 rtltqfltrt vkvnmnelqv penfevshkp tvekpvfyty trenlekaek ftdilefdnl 361 ftapsmglpd gltyyrkass inrlpnikip tliinatddp vtgenvipyk qarenpcvll 421 cetdlgghla yldnesnswl tkqaaeflgs fdelvl // LOCUS NP_015231 274 aa linear PLN 30-JUN-2025 DEFINITION Sec63 complex subunit SEC62 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015231 VERSION NP_015231.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183908.1 REFERENCE 1 (residues 1 to 274) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 274) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 274) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 274) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 274) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11339. On Feb 2, 2004 this sequence version replaced NP_015231.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..274 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..274 /product="Sec63 complex subunit SEC62" /calculated_mol_wt="31216" Region 1..259 /region_name="SEC62" /note="Preprotein translocase subunit Sec62 [Intracellular trafficking and secretion]; COG5232" /db_xref="CDD:227557" CDS 1..274 /gene="SEC62" /locus_tag="YPL094C" /gene_synonym="LPG14" /coded_by="NM_001183908.1:1..825" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095|PMID:26928762|PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0008320 protein transmembrane transporter activity [PMID:9252322]" /experiment="EXISTENCE:direct assay:GO:0031204 post-translational protein targeting to membrane, translocation [PMID:7758110]" /experiment="EXISTENCE:physical interaction:GO:0031207 Sec62/Sec63 complex [PMID:2000150]" /note="Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; cotranslationally N-acetylated by NatA; other members are Sec63p, Sec66p, and Sec72p" /db_xref="GeneID:856011" /db_xref="SGD:S000006015" ORIGIN 1 msavgpgsna gasvnggsat aiatllrnhk elkqrqglfq akqtdffryk rfvralhsee 61 yanksarqpe iyptipsnki edqlksreif iqlikaqmvi pvkklhsqec kehglkpskd 121 fphlivsnka qleadeyfvw nynprtymdy livigvvsii lalvcyplwp rsmrrgsyyv 181 slgafgilag ffavailrli lyvlslivyk dvggfwifpn lfedcgvles fkplygfgek 241 dtysykkklk rmkkkqakre snkkkainek aeqn // LOCUS NP_015232 647 aa linear PLN 30-JUN-2025 DEFINITION putative GTPase NOG1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015232 VERSION NP_015232.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183907.1 REFERENCE 1 (residues 1 to 647) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 647) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 647) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 647) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 647) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11340. Method: conceptual translation. FEATURES Location/Qualifiers source 1..647 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..647 /product="putative GTPase NOG1" /calculated_mol_wt="74279" Region 5..347 /region_name="Nog1" /note="GTP-binding protein, GTP1/Obg family [General function prediction only]; COG1084" /db_xref="CDD:440701" Region 399..449 /region_name="NOGCT" /note="NOGCT (NUC087) domain; pfam08155" /db_xref="CDD:462381" CDS 1..647 /gene="NOG1" /locus_tag="YPL093W" /coded_by="NM_001183907.1:1..1944" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11112701]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:31909713]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:23212245|PMID:11583614|PMID:16861225|PMID:17443350]" /experiment="EXISTENCE:direct assay:GO:0042273 ribosomal large subunit biogenesis [PMID:16888624]" /experiment="EXISTENCE:mutant phenotype:GO:0000054 ribosomal subunit export from nucleus [PMID:12773575]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12773575]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:17443350]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:31909713|PMID:22735702]" /note="Putative GTPase; associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins" /db_xref="GeneID:856012" /db_xref="SGD:S000006014" ORIGIN 1 mqlswkdipt vapandlldi vlnrtqrktp tvirpgfkit rirafymrkv kytgegfvek 61 fedilkgfpn indvhpfhrd lmdtlyeknh ykislaaisr akslveqvar dyvrllkfgq 121 slfqckqlkr aalgrmativ kklrdplayl eqvrqhigrl psidpntrtl licgypnvgk 181 ssflrcitks dvdvqpyaft tkslyvghfd ykylrfqaid tpgildrpte emnniemqsi 241 yaiahlrscv lyfmdlseqc gftieaqvkl fhsikplfan ksvmvvinkt diirpedlde 301 eraqllesvk evpgveimts scqleenvme vrnkacekll asrienklks qsrinnvlnk 361 ihvaqpqard dvkrtpfipe svknlkkydp edpnrrklar dieaenggag vfnvnlkdky 421 lleddewknd impeildgkn vydfldpeia aklqaleeee eklenegfyn sddeeeiydg 481 feasevddik ekaawirnrq ktmiaearnr kslknkaimp rskltksfgk meehmstlgh 541 dmsalqdkqn raarknryve rgsdvvfgdq daltasteng vklrqtdrll dgvadgsmrs 601 kadrmakmer rernrhakqg esdrhnavsl skhlfsgkrg vgktdfr // LOCUS NP_015233 458 aa linear PLN 30-JUN-2025 DEFINITION Ssu1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015233 VERSION NP_015233.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183906.1 REFERENCE 1 (residues 1 to 458) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 458) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 458) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 458) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11341. Method: conceptual translation. FEATURES Location/Qualifiers source 1..458 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..458 /product="Ssu1p" /calculated_mol_wt="52414" Region 9..405 /region_name="TDT_SSU1" /note="Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); cd09318" /db_xref="CDD:187758" Site 361 /site_type="other" /note="gating phenylalanine in ion channel" /db_xref="CDD:187758" CDS 1..458 /gene="SSU1" /locus_tag="YPL092W" /gene_synonym="LPG16" /coded_by="NM_001183906.1:1..1377" /experiment="EXISTENCE:direct assay:GO:0000316 sulfite transmembrane transport [PMID:10870099]" /experiment="EXISTENCE:direct assay:GO:0000319 sulfite transmembrane transporter activity [PMID:10870099]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9294463]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Plasma membrane sulfite pump involved in sulfite metabolism; required for efficient sulfite efflux; major facilitator superfamily protein" /db_xref="GeneID:856013" /db_xref="SGD:S000006013" ORIGIN 1 mvanwvlalt rqfdpfmfmm vmgvgissni lysfpyparw lricsyimfa iaclifiavq 61 alqilhlivy ikeksfreyf ndffrnmkhn lfwgtypmgl vtiinflgal skanttkspt 121 narnlmifvy vlwwydlavc lviawgisfl iwhdyypleg ignypsynik masenmksvl 181 lldiiplvvv asscgtftms eiffhafnrn iqlitlvica ltwlhaiifv filiaiyfws 241 lyinkippmt qvftlflllg pmgqgsfgvl lltdnikkya gkyyptdnit reqeiltiav 301 pwcfkilgmv samallamgy fftvisvvsi lsyynkkeie netgkvkrvy tfhkgfwgmt 361 fpmgtmslgn eelyvqynqy vplyafrvlg tiyggvcvcw silcllctlh eyskkmlhaa 421 rksslfsesg tekttvspyn siesveesns aldftrla // LOCUS NP_015234 483 aa linear PLN 30-JUN-2025 DEFINITION glutathione-disulfide reductase GLR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015234 VERSION NP_015234.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183905.1 REFERENCE 1 (residues 1 to 483) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 483) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 483) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 483) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 483) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11342. Method: conceptual translation. FEATURES Location/Qualifiers source 1..483 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..483 /product="glutathione-disulfide reductase GLR1" /EC_number="1.8.1.7" /calculated_mol_wt="53310" Region 22..483 /region_name="gluta_reduc_1" /note="glutathione-disulfide reductase, animal/bacterial; TIGR01421" /db_xref="CDD:273614" CDS 1..483 /gene="GLR1" /locus_tag="YPL091W" /gene_synonym="LPG17" /coded_by="NM_001183905.1:1..1452" /experiment="EXISTENCE:direct assay:GO:0004362 glutathione-disulfide reductase (NADPH) activity [PMID:19049979|PMID:7737505]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:23613772]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:24769239|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:23613772]" /experiment="EXISTENCE:genetic interaction:GO:0010731 protein glutathionylation [PMID:20074363]" /experiment="EXISTENCE:mutant phenotype:GO:0006749 glutathione metabolic process [PMID:23242256]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:8951820]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:23242256]" /note="Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; also detected in peroxisomes; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856014" /db_xref="SGD:S000006012" ORIGIN 1 mlsatkqtfr slqirtmstn tkhydylvig ggsggvasar raasygaktl lveakalggt 61 cvnvgcvpkk vmwyasdlat rvshaneygl yqnlpldkeh ltfnwpefkq krdayvhrln 121 giyqknleke kvdvvfgwar fnkdgnvevq krdnttevys anhilvatgg kaifpenipg 181 felgtdsdgf frleeqpkkv vvvgagyigi elagvfhglg sethlvirge tvlrkfdeci 241 qntitdhyvk eginvhklsk ivkveknvet dklkihmnds ksiddvdeli wtigrkshlg 301 mgsenvgikl nshdqiiade yqntnvpniy slgdvvgkve ltpvaiaagr klsnrlfgpe 361 kfrndkldye nvpsvifshp eagsigisek eaiekygken ikvynskfta myyamlseks 421 ptrykivcag pnekvvglhi vgdssaeilq gfgvaikmga tkadfdncva ihptsaeelv 481 tmr // LOCUS NP_015235 236 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein eS6 RPS6A [Saccharomyces cerevisiae S288C]. ACCESSION NP_015235 VERSION NP_015235.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183904.1 REFERENCE 1 (residues 1 to 236) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 236) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 236) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 236) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 236) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11343. Method: conceptual translation. FEATURES Location/Qualifiers source 1..236 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..236 /product="40S ribosomal protein eS6 RPS6A" /calculated_mol_wt="26865" Region 1..220 /region_name="Ribosomal_S6e" /note="Ribosomal protein S6e; cl00931" /db_xref="CDD:469996" CDS 1..236 /gene="RPS6A" /locus_tag="YPL090C" /coded_by="NM_001183904.1:1..711" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication" /db_xref="GeneID:856015" /db_xref="SGD:S000006011" ORIGIN 1 mklnisypvn gsqktfeidd ehrirvffdk rigqevdgea vgdefkgyvf kisggndkqg 61 fpmkqgvllp trikllltkn vscyrprrdg erkrksvrga ivgpdlavla lvivkkgeqe 121 legltdttvp krlgpkrann irkffglske ddvrdfvirr evtkgektyt kapkiqrlvt 181 pqrlqrkrhq ralkvrnaqa qreaaaeyaq llakrlserk aekaeirkrr asslka // LOCUS NP_015236 676 aa linear PLN 30-JUN-2025 DEFINITION Rlm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015236 VERSION NP_015236.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183903.1 REFERENCE 1 (residues 1 to 676) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 676) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 676) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 676) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 676) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11344. Method: conceptual translation. FEATURES Location/Qualifiers source 1..676 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..676 /product="Rlm1p" /calculated_mol_wt="73353" Region 2..77 /region_name="MADS_MEF2_like" /note="MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS (MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I...; cd00265" /db_xref="CDD:238165" Site order(2..4,6,8,13,15,19..20,23..24,26..27,30..31,33..34,38) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238165" Site order(21,28..29,32..33,35..36,39,44,46,48,54,56,62,65..66, 69,72..73) /site_type="other" /note="dimerization interface [polypeptide binding]" /db_xref="CDD:238165" Site 59 /site_type="other" /note="putative phosphorylation site [posttranslational modification]" /db_xref="CDD:238165" Region 146..673 /region_name="ARG80" /note="Regulator of arginine metabolism and related MADS box-containing transcription factors [Transcription]; COG5068" /db_xref="CDD:227400" CDS 1..676 /gene="RLM1" /locus_tag="YPL089C" /coded_by="NM_001183903.1:1..2031" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9121433]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12410835]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:10064699]" /experiment="EXISTENCE:direct assay:GO:0033554 cellular response to stress [PMID:15116342]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:9121433]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15116342|PMID:9121433|PMID:12410835]" /experiment="EXISTENCE:mutant phenotype:GO:0007165 signal transduction [PMID:7565726]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:12410835]" /experiment="EXISTENCE:mutant phenotype:GO:0034605 cellular response to heat [PMID:20398213]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:20398213|PMID:12410835]" /experiment="EXISTENCE:mutant phenotype:GO:0060256 regulation of flocculation [PMID:31441971]" /experiment="EXISTENCE:mutant phenotype:GO:1903450 regulation of G1 to G0 transition [PMID:31141453]" /note="MADS-box transcription factor; component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p; RLM1 has a paralog, SMP1, that arose from the whole genome duplication" /db_xref="GeneID:856016" /db_xref="SGD:S000006010" ORIGIN 1 mgrrkieiqr isddrnravt fikrkaglfk kahelsvlcq vdiaviilgs nntfyefssv 61 dtndliyhyq ndknllhevk dpsdygdfhk sasvninqdl lrssmsnkps ksnvkgmnqs 121 endddennde ddddhgnfer nsnmhsnkka sdknipsahm kllsptalis kmdgseqnkr 181 hpenalpplq hlkrlkpdpl qisrtpqqqq qqnisrpyhs smynlnqpss sssspstmdf 241 pklpsfqnss fngrpppisi spnkfskpft nassrtpkqe hkinnsgsnn ndnsnytqsp 301 snsledsiqq tvkarrklsa rpvlrvripn nnfssnsaip sepssassts angnsmgssq 361 imkenktsrs skisplsasa sgpltlqkgn ngrmviklpn anapngsnng ngsnnnnhpy 421 pfgsgssplf satqpyiatp lqpsnipggp fqqntsflaq rqtqqyqqms fkkqsqtvpl 481 tttltgrpps tfsgpetsng pptgslpskf vhdlmsnspn vssismfpdw smgpnsakpg 541 ntnnpgtfpp vqtavnngns snisstnntn nnnnnnnnns snnnsnngnd nnsnnsnnsy 601 ysnnedapvn gaaisehttd gdsnnqsnss tydaaatayn gntgltpyin taqtplgtkf 661 fnfstdisge knsski // LOCUS NP_015237 342 aa linear PLN 30-JUN-2025 DEFINITION aldo-keto reductase superfamily protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_015237 VERSION NP_015237.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183902.1 REFERENCE 1 (residues 1 to 342) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 342) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 342) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 342) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 342) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11345. Method: conceptual translation. FEATURES Location/Qualifiers source 1..342 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..342 /product="aldo-keto reductase superfamily protein" /calculated_mol_wt="39552" Region 5..332 /region_name="AKR_EcYajO-like" /note="Escherichia coli YajO and similar proteins; cd19079" /db_xref="CDD:381305" Site order(22..24,58,63,91,148..149,178..179,204,232..238,288, 303..308,311,314..315) /site_type="active" /note="putative active site [active]" /db_xref="CDD:381305" Site order(58,63,91,148) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381305" CDS 1..342 /locus_tag="YPL088W" /coded_by="NM_001183902.1:1..1029" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:31945465]" /note="Putative aryl alcohol dehydrogenase; localizes to cytosol; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance" /db_xref="GeneID:856017" /db_xref="SGD:S000006009" ORIGIN 1 mvlvkqvrlg nsglkispiv igcmsygskk wadwviedkt qifkimkhcy dkglrtfdta 61 dfysnglser iikefleyys ikretvvimt kiyfpvdetl dlhhnftlne feeldlsnqr 121 glsrkhiiag vensvkrlgt yidllqihrl dhetpmkeim kalndvveag hvryigassm 181 latefaelqf tadkygwfqf issqsyynll yrederelip fakrhnigll pwspnargml 241 trplnqstdr iksdptfksl hldnleeeqk eiinrvekvs kdkkvsmaml siawvlhkgc 301 hpivglntta rvdeaiaalq vtlteeeiky leepykpqrq rc // LOCUS NP_015238 317 aa linear PLN 30-JUN-2025 DEFINITION alkaline dihydroceramidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015238 VERSION NP_015238.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183901.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11346. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..317 /product="alkaline dihydroceramidase" /calculated_mol_wt="37100" Region 17..286 /region_name="Ceramidase" /note="pfam05875" /db_xref="CDD:461766" CDS 1..317 /gene="YDC1" /locus_tag="YPL087W" /coded_by="NM_001183901.1:1..954" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:10900202]" /experiment="EXISTENCE:direct assay:GO:0017040 N-acylsphingosine amidohydrolase activity [PMID:10900202]" /experiment="EXISTENCE:genetic interaction:GO:0046513 ceramide biosynthetic process [PMID:11694577]" /experiment="EXISTENCE:mutant phenotype:GO:0046514 ceramide catabolic process [PMID:10900202]" /note="Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication" /db_xref="GeneID:856018" /db_xref="SGD:S000006008" ORIGIN 1 mlfswpypea piegywgkpt slidwceeny vvspyiaews ntitnsiflm tafystysaw 61 rnkletryil igmgfslvgi gswlfhmtlq yryqlldelp mlyatiipsw sifaetqeil 121 ikdekkrkes sfriqmvisf imcgivtilt wiyvvvqkpa ifqvlygilt llvvvlsgwl 181 tyyhvhdsfa kknlfitmvm gmipfvigfi cwqldihlcs fwiyirrtyl alplgvllel 241 hawwhlltgt gvyifvvylq ylrilthgnp ndflfiwrwg ffpelvrkgl pigtsysley 301 lgpivntqvd detkknn // LOCUS NP_015239 557 aa linear PLN 30-JUN-2025 DEFINITION Elongator subunit ELP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015239 VERSION NP_015239.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183900.1 REFERENCE 1 (residues 1 to 557) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 557) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 557) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 557) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 557) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11347. Method: conceptual translation. FEATURES Location/Qualifiers source 1..557 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..557 /product="Elongator subunit ELP3" /EC_number="2.3.1.311" /calculated_mol_wt="63526" Region 32..557 /region_name="ELP3" /note="radical SAM enzyme/protein acetyltransferase, ELP3 family; TIGR01211" /db_xref="CDD:273503" CDS 1..557 /gene="ELP3" /locus_tag="YPL086C" /gene_synonym="HPA1; KAT9; KTI8; TOT3" /coded_by="NM_001183900.1:1..1674" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12139626]" /experiment="EXISTENCE:direct assay:GO:0033588 elongator holoenzyme complex [PMID:11689709]" /experiment="EXISTENCE:mutant phenotype:GO:0002098 tRNA wobble uridine modification [PMID:18755837]" /note="Subunit of Elongator complex; Elongator is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin; human homolog ELP3 can partially complement yeast elp3 null mutant" /db_xref="GeneID:856019" /db_xref="SGD:S000006007" ORIGIN 1 marhgkgpkt nkkklapeke rfiqccadit leltdsltsg ttreinlngl itkyskkykl 61 kqqprltdii nsipdqykky llpklkakpv rtasgiavva vmckphrcph iaytgnicvy 121 cpggpdsdfe ystqsytgye ptsmrairar ydpyeqargr veqlkqlghs idkveyvlmg 181 gtfmslpkey redfivklhn alsgfngndi deailysqqs ltkcvgitie trpdyctqth 241 lddmlkygct rleigvqsly edvardtnrg htvrsvcetf avskdagykv vshmmpdlpn 301 vgmerdieqf keyfenpdfr tdglkiyptl virgtglyel wktgryksys analvdlvar 361 ilalvppwtr iyrvqrdipm plvtsgvdng nlrelalarm kdlgttcrdv rtrevgiqev 421 hhkvqpdqve lirrdyyang gwetflsyed pkkdiligll rlrkaskkyt yrkeftsqrt 481 sivrelhvyg svvplhsrdp rkfqhqgfgt llmeeaeria keehgsekis visgvgvrny 541 ygklgyeldg pymskri // LOCUS NP_015240 2195 aa linear PLN 30-JUN-2025 DEFINITION COPII coat assembly protein SEC16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015240 VERSION NP_015240.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183899.1 REFERENCE 1 (residues 1 to 2195) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2195) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 2195) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2195) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11348. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2195 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..2195 /product="COPII coat assembly protein SEC16" /calculated_mol_wt="241566" Region 291..567 /region_name="Sec16_N" /note="Vesicle coat trafficking protein Sec16 N-terminus; pfam12935" /db_xref="CDD:315590" Region <680..980 /region_name="PHA03247" /note="large tegument protein UL36; Provisional" /db_xref="CDD:223021" Region 994..1093 /region_name="Sec16" /note="Vesicle coat trafficking protein Sec16 mid-region; pfam12932" /db_xref="CDD:432885" Site order(1131..1132,1134..1135,1137..1141,1143,1145,1155,1157, 1159..1160,1162..1163,1167,1173,1180,1198,1203,1206, 1240..1241) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:187750" Region 1136..1420 /region_name="Sec16_C" /note="Sec23-binding domain of Sec16; pfam12931" /db_xref="CDD:432884" Site order(1314,1336..1337,1339..1340,1343..1344,1347, 1376..1377,1380..1381,1384,1388) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:187750" CDS 1..2195 /gene="SEC16" /locus_tag="YPL085W" /gene_synonym="LPF1" /coded_by="NM_001183899.1:1..6588" /experiment="EXISTENCE:direct assay:GO:0012507 ER to Golgi transport vesicle membrane [PMID:7593161]" /experiment="EXISTENCE:direct assay:GO:0043495 protein-membrane adaptor activity [PMID:12235121|PMID:7593161]" /experiment="EXISTENCE:direct assay:GO:0048208 COPII vesicle coating [PMID:12235121]" /experiment="EXISTENCE:direct assay:GO:0070971 endoplasmic reticulum exit site [PMID:22675024]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11694599]" /experiment="EXISTENCE:mutant phenotype:GO:0070973 protein localization to endoplasmic reticulum exit site [PMID:22675024]" /note="COPII vesicle coat protein required for ER transport vesicle budding; essential factor in endoplasmic reticulum exit site (ERES) formation, as well as in COPII-mediated ER-to-Golgi traffic; bound to periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p" /db_xref="GeneID:856020" /db_xref="SGD:S000006006" ORIGIN 1 mtpeakkrkn qkkklkqkqk kaaekaashs eeplelpest inssfnddsv nrtesdiask 61 sdvppvssst nispanetql eipdtqelhh kllndsdqhd itadsndlpd nsivehdsvi 121 tqtkpamsqe yeetaahlss rnpsldvvag elhnnnehtq kiavsaveed sfneeegenh 181 dsiiisslnd atpsqynhfl psdgnllspe lssgdtpthn vplgtkdnei nddeycndke 241 islnannvlp delskeeder lklethvste ekkqdiadqe taenlftsst epsenkirns 301 gddtsmlfqd desdqkvpwe edvkkdfhne ntnntqesap ntddrdkgye gnealkkses 361 ctaadersys eetsedifhg hdkqvvegqn dftgkniene sqklmgegnh klplsaeadi 421 iepgkdiqdq aedlftqssg dlgevlpwes tdknadvtsk sqekhedlfa asgndeklpw 481 evsdgevssg ktensmqtst ekiaeqkfsf lendddlldd ddsflassee edtvpntdnt 541 tnltskpvee kkasrykpii eeeagmrqeq vhftnttgiv tpqqfhgltk tglgtpnqqv 601 svpnivspkp pvvkdnrsnf kineekkksd aydfpleiis esskkghakp vavptqrfgs 661 gnsfssldkp ipqsrkgsnn snrppviplg tqeprssrtn saisqspvny afpnpykiqq 721 lqqapiqsgm plpntnippp alkvettvsa ppirargvsn asvgssasfg arhatqygln 781 ngvppvspyg qatinlptan kyapvsptvq qkqypsvvqn lgasavntpn fvkthrghts 841 sissytpnqn ehasryapny qqsyqvpyts qpvgpvagns syqsqtrssy avpmmpqaqt 901 sasiqphani qpptgilpla plrpldplqa atnlqprasn itaanslpla nlplaenilp 961 eiithratss vapprqennp ikidneallr rqfpifhwsa ankvvyavpp ipdqsqymis 1021 ssivqeikvt pidqiikpnd mlksfpgplg saklkkkdlt kwmettiksi senesstdmt 1081 iwqllemkln dkvnwknisk llynsdellm ylsqpfpngd mipnayrldi ncqmrvlafl 1141 qtgnhdealr lalskrdyai allvgslmgk drwseviqky lyegftagpn dqkelahfll 1201 lifqvfvgns kmaiksfytn netsqwasen wksivaavli nipennedpl lippvvlefl 1261 iefgifltkk gltaaastlf iignvplsne pvmadsdvif esignmntfe silwdeiyey 1321 ifsydpkfkg fssilpqkiy hasllqeqgl nslgtkytdy lsssvrklpk kdiltinltr 1381 elsevasrls esntgwlakp klssvwgqld ksfnkyiggd didalnkknd kkkvfdgftp 1441 gssansstvd ltqtftpfqa qvtsqsyvdt tallhnahnv pshsvlhskp snvskglvea 1501 nlpythrigd slqgspqrih ntqfaaaepq maslrrvrtd qhtnekalks qqilekksta 1561 ytpqfgqnhs vpmeksnsnv pslfadfpap pklgtvpsny vsspdlvrre siistgsefl 1621 pppkigvptk anssqgslmy spsvealpid pvvpqvhetg yndfgnkhsq ksmpedesht 1681 shdnsnadqn tlkdsadvtd etmdiegpgf ndvknllpme pnhqptstvn piqtisddiq 1741 pilqtnvevr gtdaskmens lpsienerss eeqpenisks assaylpstg glslenrplt 1801 qdensisetv qstylpagsi smeakpisqv qdvprnvnnk asklveqhma ppkpkstdat 1861 kmnyspyvpq staasadgde stilktspai yarthqahas npsqyfplvn qanetasfel 1921 sestsqaqsn gnvasenrfs pikkaevvek dtfqptirka stnqyrafkp lesdadkynd 1981 viedesdddn mstdeaknrk eekknvnmkk etkpsnkdid dksngwfgwl kkdtgdkkvy 2041 kaklghkntl yydeklkrwv nkdateeekq kiiessappp ppivkrkdgg pktkprsgpi 2101 nnslppvhat svipnnpitg eplpiktsps ptgpnpnnsp spsspisris gvnltskkan 2161 glddllslag gpkpastrrk kktargyvnv mdniq // LOCUS NP_015241 844 aa linear PLN 30-JUN-2025 DEFINITION Bro1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015241 VERSION NP_015241.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183898.1 REFERENCE 1 (residues 1 to 844) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 844) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 844) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 844) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 844) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 844) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 844) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11349. Method: conceptual translation. FEATURES Location/Qualifiers source 1..844 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..844 /product="Bro1p" /calculated_mol_wt="97145" Region 5..347 /region_name="BRO1_ScBro1_like" /note="Protein-interacting, N-terminal, Bro1-like domain of Saccharomyces cerevisiae Bro1 and related proteins; cd09242" /db_xref="CDD:185765" Site order(128,131,138,141,144..145,189,192..193,196,205, 208..209,336,338,340,342,347) /site_type="other" /note="putative Snf7 binding site" /db_xref="CDD:185765" Region 368..702 /region_name="V_ScBro1_like" /note="Protein-interacting V-domain of Saccharomyces cerevisiae Bro1 and related domains; cd09237" /db_xref="CDD:185750" Site order(436,490,494,497..498,680,683..684,687,690) /site_type="other" /note="putative YPXnL-motif binding site" /db_xref="CDD:185750" CDS 1..844 /gene="BRO1" /locus_tag="YPL084W" /gene_synonym="ASI6; LPF2; NPI3; VPS31" /coded_by="NM_001183898.1:1..2535" /experiment="EXISTENCE:direct assay:GO:0005515 protein binding [PMID:34908216]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12668726]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:34908216|PMID:12668726|PMID:15935782]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0035800 deubiquitinase activator activity [PMID:17446860]" /experiment="EXISTENCE:direct assay:GO:1903003 positive regulation of protein deubiquitination [PMID:17446860]" /experiment="EXISTENCE:direct assay:GO:1903561 extracellular vesicle [PMID:38711329]" /experiment="EXISTENCE:genetic interaction:GO:0016579 protein deubiquitination [PMID:15326198]" /experiment="EXISTENCE:genetic interaction:GO:0070676 intralumenal vesicle formation [PMID:23444383]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:12062418]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:12668726]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:34908216]" /experiment="EXISTENCE:mutant phenotype:GO:0036010 protein localization to endosome [PMID:15326198]" /experiment="EXISTENCE:mutant phenotype:GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [PMID:14523026]" /experiment="EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:23444383]" /experiment="EXISTENCE:mutant phenotype:GO:0072671 mitochondria-associated ubiquitin-dependent protein catabolic process [PMID:21070972]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0016579 protein deubiquitination [PMID:15326198]" /note="Cytoplasmic class E vacuolar protein sorting (VPS) factor; coordinates protein sorting and deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes; required for ESCRT-dependent transport of ubiquitinated cargo to the vacuole; localizes to extracellular vesicles during heat conditioning with proposed function in thermotolerance; orthologous to mammalian ESCRT-associated protein ALIX (PDCD6IP)" /db_xref="GeneID:856021" /db_xref="SGD:S000006005" ORIGIN 1 mkpylfdlkl kdtekldwkk glssylkksy gssqwrtfyd ekatseldhl rnnangelap 61 sslseqnlky ysflehlyfr lgskgsrlkm dftwydaeys saqkglkytq htlafeksct 121 lfniaviftq iareninedy knsianltka fscfeylsen flnspsvdlq sentrflani 181 chaeaqelfv lkllndqiss kqytliskls ratcnlfqkc hdfmkeiddd vaiygepkwk 241 ttvtcklhfy kslsayyhgl hleeenrvge aiafldfsmq qlisslpfkt wlvefidfdg 301 fketlekkqk elikdndfiy hesvpavvqv dsikaldaik sptwekilep ymqdvankcd 361 slyrgiipld vyekesiyse ekatllrkqv eetetanley ssfieftnlp rllsdlekqf 421 sdgnifsntd tqgqlmrdqi qtwckfiqtn efrdieeqmn kivfkrkqil eilsalpndq 481 kenvtklkss lvaasnsdek lfacvkphiv einllndngk iwkkfdefnr ntppqpslld 541 iddtkndkil ellkqvkgha edlrtlkeer srnlselrde inndditkll iinkgksdve 601 lkdlfevele kfeplstrie atiykqssmi ddikakldei fhlsnfkdks sgeekfledr 661 knffdklqea vksfsifasd lpkgiefyds lfnmsrdlae rvrvakqted stanspappl 721 ppldskasvv ggppllpqks aafqslsrqg lnlgdqfqnl kisagsdlpq gpgipprtye 781 aspyaatptm aappvppkqs qedmydlrrr kaveneerel qenptsfynr psvfdenmys 841 kyss // LOCUS NP_015242 467 aa linear PLN 30-JUN-2025 DEFINITION tRNA splicing endonuclease subunit SEN54 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015242 VERSION NP_015242.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183897.1 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11350. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..467 /product="tRNA splicing endonuclease subunit SEN54" /calculated_mol_wt="54518" Region 75..144 /region_name="tRNA_int_end_N2" /note="tRNA-splicing endonuclease subunit sen54 N-term; pfam12928" /db_xref="CDD:463754" CDS 1..467 /gene="SEN54" /locus_tag="YPL083C" /coded_by="NM_001183897.1:1..1404" /experiment="EXISTENCE:direct assay:GO:0000213 tRNA-intron lyase activity [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0000214 tRNA-intron endonuclease complex [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0000379 tRNA-type intron splice site recognition and cleavage [PMID:9200603]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:12925762|PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0005741 mitochondrial outer membrane [PMID:12925762]" /note="Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface" /db_xref="GeneID:856022" /db_xref="SGD:S000006004" ORIGIN 1 mqfagkktdq vttsnpgfee eeeeeeelqq dwsqlaslvs knaalslpkr gekdyepdgt 61 nlqdlllyna skamfdtisd sirgttvkse vrgyyvphkh qavllkpkgs fmqtmgrads 121 tgelwldfhe fvylaergti lpyyrleags nksskhetei llsmedlysl fssqqemdqy 181 fvfahlkrlg filkpsnqea avktsffplk kqrsnlqait wrllslfkiq elslfsgffy 241 skwnfffrky ttspqlyqgl nrlvrsvavp knkkelldaq sdrefqkvkd ipltfkvwkp 301 hsnfkkrdpg lpdfqvfvyn knddlqhfpt ykelrsmfss ldykfeflse ieddddwetn 361 syvediprke yihkrsaksq teksessmka sfqkktaqss tkkkrkaypp hiqqnrrlkt 421 gyrsfiiaim dnglisfvkm seadfgsesv wytpntqkkv dqrwkkh // LOCUS NP_015243 1867 aa linear PLN 30-JUN-2025 DEFINITION DNA-binding ATPase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015243 VERSION NP_015243.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183896.1 REFERENCE 1 (residues 1 to 1867) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1867) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1867) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1867) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1867) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1867) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1867) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11351. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1867 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1867 /product="DNA-binding ATPase" /calculated_mol_wt="209846" Region 360..385 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Site order(377..378,381,384..385,424..425,431,434..435,438, 467..468,471,474..475,478,511..512,515,518..519,563..564, 567,570..571) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:293787" Region 406..438 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 449..481 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 490..519 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 543..572 /region_name="HEAT repeat" /note="HEAT repeat [structural motif]" /db_xref="CDD:293787" Region 611..1063 /region_name="DUF3535" /note="Domain of unknown function (DUF3535); pfam12054" /db_xref="CDD:463447" Region <1258..1781 /region_name="HepA" /note="Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair]; COG0553" /db_xref="CDD:440319" CDS 1..1867 /gene="MOT1" /locus_tag="YPL082C" /gene_synonym="BUR3; END10; LPF4" /coded_by="NM_001183896.1:1..5604" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11880621]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:22298788]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:21976730|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9234740]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:9234740]" /experiment="EXISTENCE:direct assay:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:17296733]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:17296733]" /experiment="EXISTENCE:mutant phenotype:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:17296733]" /experiment="EXISTENCE:mutant phenotype:GO:0045892 negative regulation of DNA-templated transcription [PMID:24459134]" /experiment="EXISTENCE:mutant phenotype:GO:0045898 regulation of RNA polymerase II transcription preinitiation complex assembly [PMID:21976730|PMID:15861138]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27226635]" /experiment="EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:8083216]" /note="Essential protein involved in regulation of transcription; removes Spt15p (TBP) from DNA via its C-terminal ATPase activity; may have a role in ensuring that soluble TBP is available to bind TATA-less promoters; forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity; the Mot1p-Spt15p-DNA ternary complex contains unbent DNA; coregulates transcription with Spt16p through assembly of preinitiation complex and organization of nucleosomes" /db_xref="GeneID:856023" /db_xref="SGD:S000006003" ORIGIN 1 mtsrvsrldr qvilietgst qvvrnmaadq mgdlakqhpe dilsllsrvy pfllvkkwet 61 rvtaaravgg ivahapswdp nesdlvggtn egspldnaqv klehemkikl eeatqnnqln 121 llqedhhlss lsdwklneil ksgkvllass mndynvlgka ddnirkqakt ddikqetsml 181 nasdkanenk snankksarm lamarrkkkm sakntpkhpv ditessvskt llngknmtns 241 aaslatspts nqlnpkleit eqadesklmi estvrplleq heivaglvwq fqgiyellld 301 nlmsenweir hgaalglrel vkkhaygvsr vkgntreenn lrnsrsledl asrlltvfal 361 drfgdyvydt vvapvresva qtlaallihl dstlsikifn cleqlvlqdp lqtglpnkiw 421 eathggllgi ryfvsiktnf lfahgllenv vrivlyglnq sdddvqsvaa siltpitsef 481 vklnnstiei lvttiwslla rldddisssv gsimdllakl cdhqevldil knkalehpse 541 wsfkslvpkl ypflrhsiss vrravlnlli aflsikddst knwlngkvfr lvfqnilleq 601 npellqlsfd vyvallehyk vkhtektldh vfskhlqpil hllntpvgek gknyamesqy 661 ilkpsqhyql hpekkrsise tttdsdipip knnehinida pmiagditll gldvilntri 721 mgakafaltl smfqdstlqs fftnvlvrcl elpfstprml agiivsqfcs swlqkhpege 781 klpsfvseif spvmnkqlln rdefpvfrel vpslkalrtq cqsllatfvd vgmlpqyklp 841 nvaivvqget eagphafgve taekvygeyy dkmfksmnns ykllakkple dskhrvlmai 901 nsakesaklr tgsilanyas sillfdglpl klnpiirslm dsvkeernek lqtmagesvv 961 hliqqllenn kvnvsgkivk nlcgflcvdt sevpdfsvna eykekiltli kesnsiaaqd 1021 dinlakmsee aqlkrkggli tlkilfevlg psilqklpql rsilfdslsd heneeaskvd 1081 neqgqkivds fgvlralfpf msdslrssev ftrfpvlltf lrsnlsvfry saartfadla 1141 kissvevmay tireilplmn sagslsdrqg steliyhlsl smetdvlpyv iflivpllgr 1201 msdsnedvrn latttfasii klvpleagia dpkglpeelv asrererdfi qqmmdpskak 1261 pfklpiaika tlrkyqqdgv nwlaflnkyh lhgilcddmg lgktlqtici iasdqylrke 1321 dyektrsves ralpsliicp psltghwene fdqyapflkv vvyaggptvr ltlrpqlsda 1381 diivtsydva rndlavlnkt eynycvldeg hiiknsqskl akavkeitan hrliltgtpi 1441 qnnvlelwsl fdflmpgflg tekmfqerfa kpiaasrnsk tsskeqeagv lalealhkqv 1501 lpfmlrrlke dvlsdlppki iqdyycelgd lqkqlymdft kkqknvvekd ienseiadgk 1561 qhifqalqym rklcnhpalv lspnhpqlaq vqdylkqtgl dlhdiinapk lsalrtllfe 1621 cgigeedidk kasqdqnfpi qnvisqhral ifcqlkdmld mvendlfkky mpsvtymrld 1681 gsidprdrqk vvrkfnedps idclllttkv gglglnltga dtvifvehdw npmndlqamd 1741 rahrigqkkv vnvyriitkg tleekimglq kfkmniastv vnqqnsglas mdthqlldlf 1801 dpdnvtsqdn eeknngdsqa akgmediane tgltgkakea lgelkelwdp sqyeeeynld 1861 tfiktlr // LOCUS NP_015244 197 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS4 RPS9A [Saccharomyces cerevisiae S288C]. ACCESSION NP_015244 VERSION NP_015244.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183895.1 REFERENCE 1 (residues 1 to 197) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 197) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 197) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 197) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 197) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11352. Method: conceptual translation. FEATURES Location/Qualifiers source 1..197 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..197 /product="40S ribosomal protein uS4 RPS9A" /calculated_mol_wt="22312" Region 1..181 /region_name="PTZ00155" /note="40S ribosomal protein S9; Provisional" /db_xref="CDD:185484" CDS 1..197 /gene="RPS9A" /locus_tag="YPL081W" /coded_by="NM_001183895.1:1..594" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0019843 rRNA binding [PMID:16540469]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:mutant phenotype:GO:0019843 rRNA binding [PMID:16540469]" /note="Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S9 and bacterial S4; RPS9A has a paralog, RPS9B, that arose from the whole genome duplication" /db_xref="GeneID:856024" /db_xref="SGD:S000006002" ORIGIN 1 mpraprtysk tystpkrpye ssrldaelkl agefglknkk eiyrisfqls kirraardll 61 trdekdpkrl fegnalirrl vrvgvlsedk kkldyvlalk vedflerrlq tqvyklglak 121 svhharvlit qrhiavgkqi vnipsfmvrl dsekhidfap tspfggarpg rvarrnaark 181 aeasgeaade adeadee // LOCUS NP_001335822 108 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL080C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335822 VERSION NP_001335822.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348884.1 REFERENCE 1 (residues 1 to 108) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 108) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 108) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 108) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 108) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80342. Method: conceptual translation. FEATURES Location/Qualifiers source 1..108 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..108 /product="uncharacterized protein" /calculated_mol_wt="12333" CDS 1..108 /locus_tag="YPL080C" /coded_by="NM_001348884.1:1..327" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:856025" /db_xref="SGD:S000006001" ORIGIN 1 mdgsylthry calkrpytah lllldfskde vtknvwrwkg tdvklhkmgr ksivaavynq 61 ahpshpplyh lgnlngdkyv asppsrmkav slsfaftfly yyfplptn // LOCUS NP_015246 160 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL21 RPL21B [Saccharomyces cerevisiae S288C]. ACCESSION NP_015246 VERSION NP_015246.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183893.1 REFERENCE 1 (residues 1 to 160) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 160) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 160) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 160) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 160) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11353. Method: conceptual translation. FEATURES Location/Qualifiers source 1..160 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..160 /product="60S ribosomal protein eL21 RPL21B" /calculated_mol_wt="18143" Region 1..157 /region_name="PTZ00189" /note="60S ribosomal protein L21; Provisional" /db_xref="CDD:240309" CDS 1..160 /gene="RPL21B" /locus_tag="YPL079W" /coded_by="NM_001183893.1:1..483" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication" /db_xref="GeneID:856026" /db_xref="SGD:S000006000" ORIGIN 1 mgkshgyrsr trymfqrdfr khgavhmsty lkiykvgdiv dikangsiqk gmphkfyqgk 61 tgvvynvtks svgviinkmv gnrylekrln lrvehikhsk crqeflervk anaakraeak 121 aqgvavqlkr qpaqpresri vstegnvpqt lapvpyetfi // LOCUS NP_015247 244 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit 4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015247 VERSION NP_015247.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183892.1 REFERENCE 1 (residues 1 to 244) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 244) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 244) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 244) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 244) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11354. Method: conceptual translation. FEATURES Location/Qualifiers source 1..244 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..244 /product="F1F0 ATP synthase subunit 4" /calculated_mol_wt="26794" Region 75..237 /region_name="Mt_ATP-synt_B" /note="Mitochondrial ATP synthase B chain precursor (ATP-synt_B); pfam05405" /db_xref="CDD:368426" CDS 1..244 /gene="ATP4" /locus_tag="YPL078C" /gene_synonym="LPF7" /coded_by="NM_001183892.1:1..735" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0045259 proton-transporting ATP synthase complex [PMID:18722382]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:18293929]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:8068646]" /experiment="EXISTENCE:mutant phenotype:GO:0046961 proton-transporting ATPase activity, rotational mechanism [PMID:8068646]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:18293929]" /note="Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase; ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex, which in turn determines the shape of inner membrane cristae; phosphorylated" /db_xref="GeneID:856027" /db_xref="SGD:S000005999" ORIGIN 1 msmsmgvrgl alrsvsktlf sqgvrcpsmv igarymsstp ekqtdpkaka nsiinaipgn 61 niltktgvlg tsaaaviyai snelyvinde sillltflgf tglvakylap aykdfadarm 121 kkvsdvlnas rnkhveavkd ridsvsqlqn vaettkvlfd vsketveles eafelkqkve 181 laheakavld swvryeaslr qleqrqlaks visrvqselg npkfqekvlq qsiseieqll 241 sklk // LOCUS NP_015248 240 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL077C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015248 VERSION NP_015248.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183891.1 REFERENCE 1 (residues 1 to 240) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 240) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 240) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 240) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 240) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11355. Method: conceptual translation. FEATURES Location/Qualifiers source 1..240 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..240 /product="uncharacterized protein" /calculated_mol_wt="27338" Region 103..177 /region_name="DUF5315" /note="Disordered region of unknown function (DUF5315); pfam17242" /db_xref="CDD:435806" CDS 1..240 /locus_tag="YPL077C" /coded_by="NM_001183891.1:1..723" /note="hypothetical protein; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene; YPL077C has a paralog, YBR197C, that arose from the whole genome duplication" /db_xref="GeneID:856028" /db_xref="SGD:S000005998" ORIGIN 1 mkdlqkkssv rrqitnedde rygedsihdl prtipnvnpy irnsgfrpsy ssqipstrsl 61 fnnyynrssa ntvgndtidt dsvsyngvak frrnsvdipl qthnrlevrp iidrqdylwr 121 eidalddvkr qaqatelydq fppgfenklm qlrqahskll qvlrdrnaki eeeqrrevav 181 ataaammtrt psptgksvgd eatsnnmhss sairnpngpt vdpeegkyiq elvntirelq // LOCUS NP_015249 280 aa linear PLN 30-JUN-2025 DEFINITION phosphatidylinositol N-acetylglucosaminyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015249 VERSION NP_015249.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183890.1 REFERENCE 1 (residues 1 to 280) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 280) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 280) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 280) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 280) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11356. Method: conceptual translation. FEATURES Location/Qualifiers source 1..280 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..280 /product="phosphatidylinositol N-acetylglucosaminyltransferase" /EC_number="2.4.1.198" /calculated_mol_wt="32446" Region 6..273 /region_name="GPI2" /note="Phosphatidylinositol N-acetylglucosaminyltransferase; pfam06432" /db_xref="CDD:428940" CDS 1..280 /gene="GPI2" /locus_tag="YPL076W" /gene_synonym="GCR4" /coded_by="NM_001183890.1:1..843" /experiment="EXISTENCE:curator inference:GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity []" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006506 GPI anchor biosynthetic process [PMID:7768896]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:7768896]" /experiment="EXISTENCE:physical interaction:GO:0000506 glycosylphosphatidylinositol-N- acetylglucosaminyltransferase (GPI-GnT) complex [PMID:15163411]" /note="Protein involved in the synthesis of GlcNAc-PI; GlcNAc-PI is the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein; GlcNAc-PI stands for N-acetylglucosaminyl phosphatidylinositol" /db_xref="GeneID:856029" /db_xref="SGD:S000005997" ORIGIN 1 mtrspwkrll wlkqeypdny tdpsfielra rqkaesnqks drklseaara qirldfisfy 61 qtilntsfiy itftyiyyyg fdpipptifl sfitliisrt kvdpllssfm dvkssliitf 121 amltlspvlk slskttasds iwtlsfwltl wyifvisstk skdkpsnlst nilvalvavl 181 ssrlsttidv fcflliciql niilptylsv tnkvvpiisn iivysflnva lgwiymllif 241 fasvfyitvl pkwfiywkin yhkrdndlls twdartpild // LOCUS NP_015250 785 aa linear PLN 30-JUN-2025 DEFINITION transcription regulator GCR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015250 VERSION NP_015250.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183889.1 REFERENCE 1 (residues 1 to 785) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 785) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 785) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 785) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 785) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11357. Method: conceptual translation. FEATURES Location/Qualifiers source 1..785 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..785 /product="transcription regulator GCR1" /calculated_mol_wt="87598" Region 362..>616 /region_name="PHA03307" /note="transcriptional regulator ICP4; Provisional" /db_xref="CDD:223039" Region 638..730 /region_name="GCR1_C" /note="Transcriptional activator of glycolytic enzymes; pfam12550" /db_xref="CDD:432628" CDS 1..785 /gene="GCR1" /locus_tag="YPL075W" /gene_synonym="LPF10; SIT3" /coded_by="NM_001183889.1:1..2358" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:12655409|PMID:9271107|PMID:1588965|PMID:7808400|PMID :1946357|PMID:10455229|PMID:9335590]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9335590]" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15817685]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:12655409]" /experiment="EXISTENCE:mutant phenotype:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:1588965]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:9271107]" /experiment="EXISTENCE:mutant phenotype:GO:0006110 regulation of glycolytic process [PMID:3547083|PMID:11333224|PMID:10510295|PMID:7808400]" /experiment="EXISTENCE:mutant phenotype:GO:0034728 nucleosome organization [PMID:2854200]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9335590|PMID:10510295|PMID:3547083|PMID:15789351|PMI D:7808400|PMID:11333224|PMID:10455229]" /experiment="EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:11333224]" /experiment="EXISTENCE:mutant phenotype:GO:0061435 positive regulation of transcription from a mobile element promoter [PMID:9271107]" /note="Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p; contains a long intron, which allows multiple RNA and protein isoforms with varying expression levels depending on glucose availability" /db_xref="GeneID:856030" /db_xref="SGD:S000005996" ORIGIN 1 mvctstssnf ysiaqyilqs yfkvnvdsln slklvdlivd qtypdsltlr klnegatgqp 61 ydyfntvsrd adiskcpifa ltiffvirws hpnppisien fttvplldsn fislnsnpll 121 yiqnqnpnsn ssvkvsrsqt fepskelidl vfpwlsylkq dmllidrtny klyslcelfe 181 fmgrvaiqdl rylsqhplll pnivtfiskf ipelfqneef kgigsiknsn nnalnnvtgi 241 etqflnpste evsqkvdsyf melskkltte nirlsqeitq lkadmnsvgn vcnqilllqr 301 qllsgnqaig sksenivsst gggilildkn sinsnvlsnl vqsidpnhsk pngqaqthqr 361 gpkgqshaqv qstnspalap inmfpslsns iqpmlgtlap qpqdivqkrk lplpgsiasa 421 atgspfspsp vgespyskrf klddkptpsq taldslltks issprlplst lantavtesf 481 rspqqfqhsp dfvvggssss ttennskkvn edspsssskl aerprlpnnd sttsmpespt 541 evagddvdre kppessksep ndnspeskdp ekngknsnpl gtdadkpvpi snihnsteaa 601 nssgtvtkta psfpqssskf eiinkkdtka gpneaikykl srenktiwdl yaewyiglng 661 kssikklien ygwrrwkvse dshffptrri imdyietecd rgiklgrftn pqqpredirk 721 ilvgdlekfr inngltlnsl slyfrnltkn nkeicifenf knwnvrsmte eeklkyckrr 781 hntps // LOCUS NP_015251 754 aa linear PLN 30-JUN-2025 DEFINITION putative AAA family ATPase YTA6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015251 VERSION NP_015251.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183888.1 REFERENCE 1 (residues 1 to 754) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 754) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 754) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 754) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11358. Method: conceptual translation. FEATURES Location/Qualifiers source 1..754 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..754 /product="putative AAA family ATPase YTA6" /calculated_mol_wt="85169" Region <158..412 /region_name="PTZ00108" /note="DNA topoisomerase 2-like protein; Provisional" /db_xref="CDD:240271" Region 473..645 /region_name="RecA-like_VPS4-like" /note="ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; cd19509" /db_xref="CDD:410917" Site order(473..476,513..519) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:410917" Site order(481,485,489,493,538,542..543,571,588..589,592,596, 633,637..638,640) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:410917" Region 670..714 /region_name="AAA_lid_3" /note="AAA+ lid domain; pfam17862" /db_xref="CDD:465537" Region <718..750 /region_name="Vps4_C" /note="Vps4 C terminal oligomerization domain; pfam09336" /db_xref="CDD:462762" CDS 1..754 /gene="YTA6" /locus_tag="YPL074W" /coded_by="NM_001183888.1:1..2265" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005938 cell cortex [PMID:11553699]" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:32639961]" /note="Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family; localized to the cortex of mother cells but not to daughter cells; relocalizes from cytoplasm to plasma membrane foci upon DNA replication stress" /db_xref="GeneID:856031" /db_xref="SGD:S000005995" ORIGIN 1 mahekfsipe nftlaqslql lysvvknqyk nladliinsk gnkdtvtygk ihknldtllv 61 yvneglrkie ktytlkkglg nlvvdhpelr siiedfqilg qdiriarrka etlmaegngs 121 pslsssssvl glgtgnglrf pklwrmgskr dklkeadeke akinkqadni rrarkleeek 181 klgaklqyer dlelqrekli elkvkekvef evaqkleeer vkreeeerkh reqaekkris 241 tlkherktny ksrasldnfs ssskssgkid nslikrrsld vvrtsgervr tpvrksmeaa 301 eigmaaqlaw sqyqnganhs kvsnngshsn elqirykptp plkkrydykk ptvnrpiiks 361 ptlnrqnsks srniptnskl kasksntnkv srrneqnlep sspvlvsata vpaeskpmrs 421 ksgtpdkess asssldsrke dilksvqgvd rnaceqilne ilvtdekvyw ediaglrnak 481 nslkeavvyp flrpdlfkgl repvrgmllf gppgtgktmi akavatesns tffsvsassl 541 lskylgesek lvralfymak klspsiifid eidsmltars dnenessrri ktelliqwss 601 lssataqsed rnntldsrvl vlgatnlpwa iddaarrrfs rklyiplpdy etrlyhlkrl 661 makqknslqd ldyelitemt egfsgsdlts lakeaamepi rdlgdklmfa dfdkirgiei 721 kdfqnallti kksvsseslq kyeewsskfg sngs // LOCUS NP_015253 499 aa linear PLN 30-JUN-2025 DEFINITION putative ubiquitin-specific protease UBP16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015253 VERSION NP_015253.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183886.1 REFERENCE 1 (residues 1 to 499) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 499) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 499) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 499) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11359. Method: conceptual translation. FEATURES Location/Qualifiers source 1..499 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..499 /product="putative ubiquitin-specific protease UBP16" /EC_number="3.4.19.12" /calculated_mol_wt="56789" Region 54..495 /region_name="Peptidase_C19F" /note="A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl...; cd02662" /db_xref="CDD:239127" Site order(57,62,407,471) /site_type="active" /db_xref="CDD:239127" CDS 1..499 /gene="UBP16" /locus_tag="YPL072W" /coded_by="NM_001183886.1:1..1500" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:12914939|PMID:16407407]" /note="Putative deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria" /db_xref="GeneID:856032" /db_xref="SGD:S000005993" ORIGIN 1 mswiknvtes ptslikkvsc gliiaaslya iapslsalvf gdskqsigky ttvglinrgn 61 dcfitsslqg lagiprfvey lkrirtvlle letklsnnak gdnptvdntt rhsrlenssn 121 slaplheslt slildlisvk drktsispki vintlesifk skisskqnda heftlillqt 181 lqeersklid yskqicnlni pkfpfegets kflvclkckg lsepsykqtf irelsvpqqt 241 senlsnilah deteiiddys clicqirail nheeyrnfkd ctpdeilmld rlknyatkap 301 inenlpfeve qyvkryskgn lqvsnikgkv ikkdvvvqlp dilivhlsrs tfngitysrn 361 pcnvkfgeri tlseytlaes gtitenrqvk ynlksvvkht gshssghymc yrrkteirfg 421 kedessfrra pvvnnevnkn reqnvahndy kksrykkvkn alrypywqis dtaikestas 481 tvlneqkyay mlyyervnk // LOCUS NP_015254 156 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL071C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015254 VERSION NP_015254.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183885.1 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11360. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..156 /product="uncharacterized protein" /calculated_mol_wt="18304" CDS 1..156 /locus_tag="YPL071C" /coded_by="NM_001183885.1:1..471" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /db_xref="GeneID:856034" /db_xref="SGD:S000005992" ORIGIN 1 mssrfarsng npnhirkrnh spdpigidny krkrliidle nlslndkgpk nghaddnnli 61 hnnivftdai ddkvlkeiik cstskrgdnd lfydkiwerl rekrlqiikw vdykeiayls 121 wwkwfhnqmt skytydgead tdvemmavdt dvdmda // LOCUS NP_015255 612 aa linear PLN 30-JUN-2025 DEFINITION guanine nucleotide exchange factor MUK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015255 VERSION NP_015255.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183884.1 REFERENCE 1 (residues 1 to 612) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 612) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 612) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 612) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 612) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11361. Method: conceptual translation. FEATURES Location/Qualifiers source 1..612 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..612 /product="guanine nucleotide exchange factor MUK1" /calculated_mol_wt="69408" Region 313..412 /region_name="VPS9" /note="Vacuolar sorting protein 9 (VPS9) domain; cl19569" /db_xref="CDD:473191" CDS 1..612 /gene="MUK1" /locus_tag="YPL070W" /coded_by="NM_001183884.1:1..1839" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:23612966|PMID:23264632]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:23612966|PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006895 Golgi to endosome transport [PMID:23612966]" /experiment="EXISTENCE:genetic interaction:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:23612966]" /experiment="EXISTENCE:genetic interaction:GO:0036010 protein localization to endosome [PMID:23264632]" /note="Guanine nucleotide exchange factor (GEF); involved in vesicle-mediated vacuolar transport, including Golgi-endosome trafficking and sorting through the multivesicular body (MVB); specifically stimulates the intrinsic guanine nucleotide exchange activity of Rab family members (Vps21p/Ypt52p/Ypt53p); partially redundant with GEF VPS9; required for localization of the CORVET complex to endosomes; contains a VPS9 domain" /db_xref="GeneID:856035" /db_xref="SGD:S000005991" ORIGIN 1 marqlftppi tnprfdpnqs iresyknttg gmqfqqnlhe dqndnerssc dgdensttge 61 rlennkspil tkqeidealn tvtnlppels klidifiddl kqpkyvrpls vlqlsslfqs 121 fyikfdkasf qhvssannng yyfsgggsss flaaketlss glsgifgrsr sssgnslmrp 181 rrssslfsne sisnstnatq mlspeeikkq lkinelnnmk iekymelcer dvfkkilivg 241 tsvsspnkmk tfkphqlqtf kvgnlfrnsv efteynklln ekilclskls tmnkinlikf 301 lslnngidpe pkfeeikdil yeftyhsisp cekikallkl heimtysqem snddylslli 361 yyiitivprd iflnaefirl frykkklvet esfaltnlea alvfvegltk ndfsnelqdk 421 ltvneskile nsissrvslp sktaimhknn gnngsnlgdi vtptiqrpdv trsnsydgfr 481 tvfdsslkni igkirsytpp hpnntsnnnl hssnnlnipr sssqlsmels nrdttemsrd 541 gsrstssssr ssaslehgnr eftgdltvta singadkkef qkswkkykgy kfedlticel 601 rdlfeiyqkm mq // LOCUS NP_015256 335 aa linear PLN 30-JUN-2025 DEFINITION farnesyltranstransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015256 VERSION NP_015256.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183883.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11362. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..335 /product="farnesyltranstransferase" /EC_number="2.5.1.1" /EC_number="2.5.1.10" /EC_number="2.5.1.29" /calculated_mol_wt="38520" Region 20..277 /region_name="polyprenyl_synt" /note="Polyprenyl synthetase; pfam00348" /db_xref="CDD:459773" CDS 1..335 /gene="BTS1" /locus_tag="YPL069C" /coded_by="NM_001183883.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0004311 geranylgeranyl diphosphate synthase activity [PMID:7665600]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016114 terpenoid biosynthetic process [PMID:7665600]" /experiment="EXISTENCE:mutant phenotype:GO:0016114 terpenoid biosynthetic process [PMID:7665600]" /note="Geranylgeranyl diphosphate synthase (GGPPS); increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic" /db_xref="GeneID:856036" /db_xref="SGD:S000005990" ORIGIN 1 meakidelin ndpvwssqne sliskpynhi llkpgknfrl nlivqinrvm nlpkdqlaiv 61 sqivellhns slliddiedn aplrrgqtts hlifgvpsti ntanymyfra mqlvsqlttk 121 eplyhnliti fneelinlhr gqgldiywrd flpeiiptqe mylnmvmnkt gglfrltlrl 181 mealspsshh ghslvpfinl lgiiyqirdd ylnlkdfqms sekgfaedit egklsfpivh 241 alnftktkgq teqhneilri lllrtsdkdi klkliqilef dtnslaytkn finqlvnmik 301 ndnenkylpd lashsdtatn lhdellyiid hlsel // LOCUS NP_015257 293 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL068C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015257 VERSION NP_015257.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183882.1 REFERENCE 1 (residues 1 to 293) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 293) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 293) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 293) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11363. Method: conceptual translation. FEATURES Location/Qualifiers source 1..293 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..293 /product="uncharacterized protein" /calculated_mol_wt="32967" CDS 1..293 /locus_tag="YPL068C" /coded_by="NM_001183882.1:1..882" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:856037" /db_xref="SGD:S000005989" ORIGIN 1 mhmqlrkrkr vdysgrnqts dppstttaav psiivpkkrk vvaqnmvspa irattttlgt 61 sniiipkplq rpkfhnsasl sspdddpeki svlevqknls nlikrqqrlf ykdihkptla 121 glknfemlrl pndlkllqni vnllysfeql nsdsktrpvt tsklkassqa hsdklkkmla 181 erkppfshps hsgtayhndi iheianlhsi nlvdlinlev ynnnchtnnt alqttanslt 241 lnsiikkldk pilkernnsl vwphksrfka krnqpspgqs linntditly ndv // LOCUS NP_015258 198 aa linear PLN 30-JUN-2025 DEFINITION Htc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015258 VERSION NP_015258.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183881.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11364. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..198 /product="Htc1p" /calculated_mol_wt="22645" Region 18..171 /region_name="DUF3605" /note="Protein of unknown function (DUF3605); pfam12239" /db_xref="CDD:432417" CDS 1..198 /gene="HTC1" /locus_tag="YPL067C" /coded_by="NM_001183881.1:1..597" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene" /db_xref="GeneID:856038" /db_xref="SGD:S000005988" ORIGIN 1 mqqdivndhq eeaqgwkweq ikeiiesgel arlkrsrqmt dkyhehkkrt agldmnqyvl 61 qklgwsldep qlenaaakaf ssstlyavra ndfpynfepg vvhlvlwskv alpvhspdka 121 vreaararmn aflqaqpllr pllssghvaw fvnypelqsv arifhahvll ffprerysae 181 qvkttvddil shgfepla // LOCUS NP_015259 479 aa linear PLN 30-JUN-2025 DEFINITION Rgl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015259 VERSION NP_015259.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183880.1 REFERENCE 1 (residues 1 to 479) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 479) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 479) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 479) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 479) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11365. Method: conceptual translation. FEATURES Location/Qualifiers source 1..479 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..479 /product="Rgl1p" /calculated_mol_wt="54763" CDS 1..479 /gene="RGL1" /locus_tag="YPL066W" /coded_by="NM_001183880.1:1..1440" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0097271 protein localization to bud neck [PMID:22344253]" /experiment="EXISTENCE:physical interaction:GO:0097271 protein localization to bud neck [PMID:22344253]" /note="Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source" /db_xref="GeneID:856039" /db_xref="SGD:S000005987" ORIGIN 1 mthpvislkp synsvirgcp glpdtlprie cqlrvrsnns lpfklvkiei vlktieiyfn 61 knlyssnnss ftpfnrpsdp snghsdtsnq nisihykkni vlshpthdgd dlnndligid 121 ipltiglpdd iketnynpkf gktqtfldct vfytevgggs snkkrnflyp vnverytylp 181 spsyfrpinr snitspdqkf lisysienpc vsmnndtlkl sisirlnpfp nnattpssnd 241 fdvstptlfs tkkkfksklk lksittqile yleilknqse fsstqttnil qtsvrqvdqi 301 ismnsmifqf nlkiftkdki lqsfrssess cpetkvlink iddiplqyhs sittigqhfn 361 vshylsirfk fnkslknfei nhpliisfws vsqlplienl ilqerqtakf akkfyknfgr 421 ikntsnnnns sncleypslp piiynfndpe tnnrfnilys qkdpsrtdps klrrvpviq // LOCUS NP_015260 242 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-I subunit protein VPS28 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015260 VERSION NP_015260.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183879.1 REFERENCE 1 (residues 1 to 242) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 242) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 242) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 242) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 242) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11366. Method: conceptual translation. FEATURES Location/Qualifiers source 1..242 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..242 /product="ESCRT-I subunit protein VPS28" /calculated_mol_wt="27571" Region 40..241 /region_name="VPS28" /note="VPS28 protein; pfam03997" /db_xref="CDD:427639" CDS 1..242 /gene="VPS28" /locus_tag="YPL065W" /gene_synonym="VPL13; VPT28" /coded_by="NM_001183879.1:1..729" /experiment="EXISTENCE:direct assay:GO:0000813 ESCRT I complex [PMID:15044434]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:11511343]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0044877 protein-containing complex binding [PMID:17215868]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:11511343]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:11511343]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /experiment="EXISTENCE:physical interaction:GO:0000813 ESCRT I complex [PMID:16615894|PMID:11511343]" /experiment="EXISTENCE:physical interaction:GO:0044877 protein-containing complex binding [PMID:17215868]" /note="Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p" /db_xref="GeneID:856040" /db_xref="SGD:S000005986" ORIGIN 1 mqkhniklnq nqdisqlfhd evplfdnsit skdkevietl seiysivitl dhvekaylkd 61 siddtqytnt vdkllkqfkv ylnsqnkeei nkhfqsieaf cdtynitasn aitrlergip 121 itaehaistt tsapsgdnkq ssssdkkfna kyvaeatgnf itvmdalkln ynakdqlhpl 181 laellisinr vtrddfenrs klidwivrin klsigdtlte tqirellfdl elayksfyal 241 ld // LOCUS NP_015261 301 aa linear PLN 30-JUN-2025 DEFINITION putative peptidylprolyl isomerase CWC27 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015261 VERSION NP_015261.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183878.1 REFERENCE 1 (residues 1 to 301) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 301) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 301) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 301) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11367. Method: conceptual translation. FEATURES Location/Qualifiers source 1..301 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..301 /product="putative peptidylprolyl isomerase CWC27" /EC_number="5.2.1.8" /calculated_mol_wt="34895" Region 6..167 /region_name="cyclophilin" /note="cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug...; cl00197" /db_xref="CDD:469651" Site order(54,56,60..61,63,99,101,109..110,114) /site_type="active" /db_xref="CDD:238194" CDS 1..301 /gene="CWC27" /locus_tag="YPL064C" /coded_by="NM_001183878.1:1..906" /experiment="EXISTENCE:direct assay:GO:0005684 U2-type spliceosomal complex [PMID:11884590]" /note="Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856041" /db_xref="SGD:S000005985" ORIGIN 1 mssniepqtt akcilyttkg niaielwake cpetckrfls mlsdgtftng efkelkptqw 61 lmfnanstge yrtvaeeknp rirfnrdgll gwdrrrntwf itvladskhv lndcnvfgki 121 vgksiyifre ilggeieass rdndvkrfmy pavlkdveit ipffedifgs krrlednekk 181 eqepakklvk sakvkmvyed eqedddgdvq klkprkrmil pawikddsrs egikldasld 241 qpqealirek telhdnvdea ttketesqen ikeepmdkre retlamlskf qeriknknil 301 k // LOCUS NP_015262 476 aa linear PLN 30-JUN-2025 DEFINITION protein translocase subunit TIM50 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015262 VERSION NP_015262.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183877.1 REFERENCE 1 (residues 1 to 476) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 476) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 476) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 476) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 476) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11368. Method: conceptual translation. FEATURES Location/Qualifiers source 1..476 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..476 /product="protein translocase subunit TIM50" /calculated_mol_wt="54968" Region 193..339 /region_name="NIF" /note="NLI interacting factor-like phosphatase; pfam03031" /db_xref="CDD:397254" Site order(197..201,205..206,237..240,244,277,293..294,296..298) /site_type="active" /db_xref="CDD:319823" CDS 1..476 /gene="TIM50" /locus_tag="YPL063W" /coded_by="NM_001183877.1:1..1431" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005744 TIM23 mitochondrial import inner membrane translocase complex [PMID:12437924|PMID:12437925]" /experiment="EXISTENCE:direct assay:GO:0030943 mitochondrion targeting sequence binding [PMID:18418384|PMID:19144822]" /experiment="EXISTENCE:direct assay:GO:0046902 regulation of mitochondrial membrane permeability [PMID:16763150]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:16763150]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:12437925|PMID:12437924]" /note="Essential component of the TIM23 complex; acts as receptor for the translocase of the inner mitochondrial membrane (TIM23) complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel" /db_xref="GeneID:856042" /db_xref="SGD:S000005984" ORIGIN 1 mlsilrnsvr lnsralrvvp saantltsvq asrrlltsys sflqketkdd kpksiltddm 61 lfkagvdvde kgqgkneets geggedknep sskseksrrk rqtstdikre kyanwfyifs 121 lsaltgtaiy mardwepqes eelkkdidng ytlslmykrf karfnsmfty fqeppfpdll 181 pppppppyqr pltlvitled flvhsewsqk hgwrtakrpg adyflgylsq yyeivlfssn 241 ymmysdkiae kldpihafvs ynlfkehcvy kdgvhikdls klnrdlskvi iidtdpnsyk 301 lqpenaipme pwngeaddkl vrlipfleyl atqqtkdvrp ilnsfedkkn laeefdhrvk 361 klkdkfygdh ksggnwamta lglgnslggs tkfpldlihe egqknylmfm kmieeekeki 421 riqqeqmggq tftlkdyveg nlpspeeqmk iqlekqkevd alfeeekkkk kiaesk // LOCUS NP_001335823 134 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL062W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335823 VERSION NP_001335823.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348885.1 REFERENCE 1 (residues 1 to 134) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 134) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 134) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 134) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 134) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80343. Method: conceptual translation. FEATURES Location/Qualifiers source 1..134 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..134 /product="uncharacterized protein" /calculated_mol_wt="14772" CDS 1..134 /locus_tag="YPL062W" /coded_by="NM_001348885.1:1..405" /experiment="EXISTENCE:mutant phenotype:GO:0032443 regulation of ergosterol biosynthetic process [PMID:30683746]" /experiment="EXISTENCE:mutant phenotype:GO:0051485 terpenoid biosynthetic process, mevalonate-dependent [PMID:30683746]" /note="hypothetical protein; conserved across S. cerevisiae strains; deletion decreases transcription of downstream gene ALD6; YPL062W is not an essential gene; null mutant shows decrease in terpenoid production; homozygous diploid mutant shows a decrease in glycogen accumulation" /db_xref="GeneID:856043" /db_xref="SGD:S000005983" ORIGIN 1 mieldyvkge dtiveatsts pwlmrsplar aaekrgsglf fdineghgqh rdvivaygvs 61 kpkrrsphph gnkaadkrkt tekeperkkr vgaprtckki ciqllyrfnf tvlgignvcn 121 idlllgtvsa tnai // LOCUS NP_015264 500 aa linear PLN 30-JUN-2025 DEFINITION aldehyde dehydrogenase (NADP(+)) ALD6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015264 VERSION NP_015264.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183875.1 REFERENCE 1 (residues 1 to 500) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 500) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 500) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 500) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 500) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11369. Method: conceptual translation. FEATURES Location/Qualifiers source 1..500 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..500 /product="aldehyde dehydrogenase (NADP(+)) ALD6" /EC_number="1.2.1.4" /calculated_mol_wt="54283" Region 23..498 /region_name="ALDH_F1-2_Ald2-like" /note="ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; cd07091" /db_xref="CDD:143410" Site order(169..170,172..173,196,199,228..229,233..234,247..250, 253,256..257,272..274,306,404,406,432,470) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:143410" Site order(173,272,303,306) /site_type="active" /note="catalytic residues [active]" /db_xref="CDD:143410" CDS 1..500 /gene="ALD6" /locus_tag="YPL061W" /gene_synonym="ALD1" /coded_by="NM_001183875.1:1..1503" /experiment="EXISTENCE:direct assay:GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity [PMID:9473035]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239|PMID:16806052]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:16806052]" /experiment="EXISTENCE:genetic interaction:GO:0006740 NADPH regeneration [PMID:12584194]" /experiment="EXISTENCE:mutant phenotype:GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity [PMID:9392076]" /experiment="EXISTENCE:mutant phenotype:GO:0005829 cytosol [PMID:9392076]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:15146068]" /experiment="EXISTENCE:mutant phenotype:GO:0019413 acetate biosynthetic process [PMID:11870853]" /note="Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; localizes to the mitochondrial outer surface upon oxidative stress; negative regulator of nonselective autophagy; Stb5p directly regulates the expression of ALD6 mRNA and directly binds to the ALD6 promoter" /db_xref="GeneID:856044" /db_xref="SGD:S000005982" ORIGIN 1 mtklhfdtae pvkitlpngl tyeqptglfi nnkfmkaqdg ktypvedpst entvcevssa 61 ttedveyaie cadrafhdte watqdprerg rllskladel esqidlvssi ealdngktla 121 largdvtiai nclrdaaaya dkvngrtint gdgymnfttl epigvcgqii pwnfpimmla 181 wkiapalamg nvcilkpaav tplnalyfas lckkvgipag vvnivpgpgr tvgaaltndp 241 rirklaftgs tevgksvavd ssesnlkkit lelggksahl vfddanikkt lpnlvngifk 301 nagqicssgs riyvqegiyd ellaafkayl eteikvgnpf dkanfqgait nrqqfdtimn 361 yidigkkega kiltggekvg dkgyfirptv fydvnedmri vkeeifgpvv tvakfktlee 421 gvemanssef glgsgietes lstglkvakm lkagtvwint yndfdsrvpf ggvkqsgygr 481 emgeevyhay tevkavrikl // LOCUS NP_015265 413 aa linear PLN 30-JUN-2025 DEFINITION Mfm1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015265 VERSION NP_015265.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183874.1 REFERENCE 1 (residues 1 to 413) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 413) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 413) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 413) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 413) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11370. Method: conceptual translation. FEATURES Location/Qualifiers source 1..413 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..413 /product="Mfm1p" /calculated_mol_wt="46952" Region 74..395 /region_name="Mrs2_Mfm1p-like" /note="Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; cd12823" /db_xref="CDD:213357" Site order(85,119,131,133..134,148..151,159..160,199,202, 251..252,255,294) /site_type="other" /note="Cl binding site [ion binding]" /db_xref="CDD:213357" Site order(104,107..108,120,122,163,167,190,193,197,201, 204..205,208,211..212,214..215,218,230..231,233..234, 237..238,241..242,244..245,249,251..252,255..256,259..260, 288..289,291..292,295..296,298..299,302..303,305..306, 308..310,313..320,322..334,336..338,340..345,347..350, 354..357,368..369,372..373,389,392) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:213357" CDS 1..413 /gene="MFM1" /locus_tag="YPL060W" /gene_synonym="LPE10" /coded_by="NM_001183874.1:1..1242" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:11254124]" /experiment="EXISTENCE:mutant phenotype:GO:0015095 magnesium ion transmembrane transporter activity [PMID:11254124]" /experiment="EXISTENCE:mutant phenotype:GO:0045016 mitochondrial magnesium ion transmembrane transport [PMID:11254124]" /note="Mitochondrial inner membrane magnesium transporter; involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p" /db_xref="GeneID:856045" /db_xref="SGD:S000005981" ORIGIN 1 mrafprvlpf rhqrsynnil lrtvrlfgss lssfdfsrqm pkvdpdntaa mllqknliqr 61 nnmlygygsg tirctlldst graksplvei kredlvskhg llprdlrkie ksrkndlvps 121 llvrensili slltvkalik pdmviifdsa gsgitlnsea hkdfindmkl rlknqetsel 181 nsdplpyefr aletifisal snltsemkvl ltickgvlqd lefsitrdkl rfllgqnkkl 241 ssfnkkavlv kdmlddlleq ddmlcdmylt dkkagkirvq ddhteiemll etyhnyvdei 301 vqksesaisd vktteeiini ildsnrnelm llgiryaigm lslggalflg siygmnlesf 361 ieesnyaylt vtilglistv wlyakgirhl hklqrmtlls kiktdsvhel lkk // LOCUS NP_001291944 1802 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_001291944 VERSION NP_001291944.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001305015.2 REFERENCE 1 (residues 1 to 1802) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1802) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1802) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1802) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1802) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA64692. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1802 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1802 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="207982" Region 623..723 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1322..1532 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1640..1777 /region_name="RNase_H_like" /note="Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; cl14782" /db_xref="CDD:449355" Site order(1644..1647,1682..1683,1686,1720,1760,1773) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1802 /locus_tag="YPL060C-A" /coded_by="join(NM_001305015.2:1..3314, NM_001305015.2:3316..5410)" /ribosomal_slippage="" /note="TyA Gag protein; the main structural constituent of virus-like particles (VLPs); Gag processing produces capsid proteins" /db_xref="GeneID:856047" /db_xref="SGD:S000007388" ORIGIN 1 matpvrdetr nviddnisar iqskvktndt vrqtpsslrk vsikdeqvkq yqrnlnrfkt 61 ilnglkaeee klsetddiqm laekllklge tidkvenriv dlvekiqlle tnennnilhe 121 hidatgtyyl fdtltstnkr fypkdcvfdy rtnnvenipi llnnfkkfik kyqfddvfen 181 diieidpren eilckiikeg lgesldimnt nttdifriid glknkyrslh grdvrirawe 241 kvlvdttcrn sallmnklqk lvlmekwifs kccqdcpnlk dylqeaimgt lheslrnsvk 301 qrlyniphnv ginheeflin tvietvidls piaddqiens cmycksvfhc sinckkkpnr 361 elrpdstnfs ktyylqgaqr qqqlkssake qkswnktqkk snkvynskkl viidtgsgvn 421 itndktllhn yedsnrstrf fgigknssvs vkgygyikik nghnntdnkc lltyyvpeee 481 stiiscydla kktkmvlsrk ytrlgnkiik iktkivngvi hvkmnelier psddskinai 541 kptsspgfkl nkrsitleda hkrmghtgiq qiensikhnh yeesldlike pnefwcqtck 601 iskatkrnhy tgsmnnhstd hepgsswcmd ifgpvsssna dtkrymlimv dnntrycmts 661 thfnknaeti laqirkniqy vetqfdrkvr einsdrgtef tndqieeyfi skgihhilts 721 tqdhaangra eryirtivtd attllrqsnl rvkfweyavt satnirncle hkstgklplk 781 aisrqpvtvr lmsflpfgek giiwnhnhkk lkpsglpsii lckdpnsygy kffipsknki 841 vtsdnytipn ytmdgrvrnt qniykshqfs shndneedqi etvtnlceal enyeddnkpi 901 trledlftee elsqidsnak ypspsnnleg dldyvfsdve esgdydvese lsttntsist 961 dknkilsnkd fnselastei siseidkkgl intshidedk ydekvhrips iiqeklvgsk 1021 ntikindenr isdrirskni gsilntglsr cvditdesit nkdesmhnak peliqeqfnk 1081 tnhetsfpke gsigtkckip kyrqwislkt gdtslpiktl esinnhhsnd ystnkvekfe 1141 kenhhpppie divdmsdqtd mesncqdgnn lkelkvtdkn vptdngtnvs prleqnieas 1201 gspvqtvnks aflnkefssl nmkrkrkrhd knnsltsyel erdkkrskrn rvklipdnme 1261 tvsaqkirai yyneaisknp dlkekheykq ayhkelqnlk dmkvfdvdvk ysrseipdnl 1321 ivptntiftk krngiykari vcrgdtqspd tysvittesl nhnhikiflm iannrnmfmk 1381 tldinhafly akleeeiyip hphdrrcvvk lnkalyglkq spkewndhlr qylngiglkd 1441 nsytpglyqt edknlmiavy vddcviaasn eqrldefink lksnfelkit gtliddvldt 1501 dilgmdlvyn krlgtidltl ksfinrmdkk yneelkkirk ssiphmstyk idpkkdvlqm 1561 seeefrqgvl klqqllgeln yvrhkcrydi nfavkkvarl vnyphervfy miykiiqylv 1621 rykdigihyd rdcnkdkkvi aitdasvgse ydaqsrigvi lwygmnifnv ysnkstnrcv 1681 ssteaelhai yegyadsetl kvtlkelgeg dnndivmitd skpaiqglnr syqqpkekft 1741 wikteiikek ikeksikllk itgkgniadl ltkpvsasdf krfiqvlknk itsqdilast 1801 dy // LOCUS NP_015266 150 aa linear PLN 30-JUN-2025 DEFINITION monothiol glutaredoxin GRX5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015266 VERSION NP_015266.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183873.1 REFERENCE 1 (residues 1 to 150) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 150) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 150) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 150) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 150) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11371. Method: conceptual translation. FEATURES Location/Qualifiers source 1..150 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..150 /product="monothiol glutaredoxin GRX5" /calculated_mol_wt="16800" Region 31..138 /region_name="GrxD" /note="Glutaredoxin-related protein [Posttranslational modification, protein turnover, chaperones]; COG0278" /db_xref="CDD:440047" CDS 1..150 /gene="GRX5" /locus_tag="YPL059W" /coded_by="NM_001183873.1:1..453" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11950925|PMID:15456753]" /experiment="EXISTENCE:direct assay:GO:0015036 disulfide oxidoreductase activity [PMID:12730244]" /experiment="EXISTENCE:direct assay:GO:0051537 2 iron, 2 sulfur cluster binding [PMID:23615440]" /experiment="EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:11950925]" /experiment="EXISTENCE:mutant phenotype:GO:0006970 response to osmotic stress [PMID:10567543]" /experiment="EXISTENCE:mutant phenotype:GO:0015036 disulfide oxidoreductase activity [PMID:10567543]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:11950925|PMID:12970193]" /experiment="EXISTENCE:mutant phenotype:GO:0034599 cellular response to oxidative stress [PMID:10567543]" /experiment="EXISTENCE:mutant phenotype:GO:0044571 [2Fe-2S] cluster assembly [PMID:23615440]" /experiment="EXISTENCE:mutant phenotype:GO:0044572 [4Fe-4S] cluster assembly [PMID:23615440]" /note="Glutathione-dependent oxidoreductase; mitochondrial matrix protein and subunit of an iron-sulfur assembly complex with Bol1p acting at a late stage in iron-sulfur center biogenesis; acts as a central hub in iron-sulfur cluster intermediate trafficking within mitochondria and export to the cytoplasm; hydroperoxide and superoxide-radical responsive; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p" /db_xref="GeneID:856048" /db_xref="SGD:S000005980" ORIGIN 1 mflpkfnpir sfspilrakt llryqnrmyl steirkaied aiesapvvlf mkgtpefpkc 61 gfsratigll gnqgvdpakf aaynvledpe lregikefse wptipqlyvn kefiggcdvi 121 tsmarsgela dlleeaqalv peeeeetkdr // LOCUS NP_015267 1511 aa linear PLN 30-JUN-2025 DEFINITION ATP-binding cassette multidrug transporter PDR12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015267 VERSION NP_015267.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183872.1 REFERENCE 1 (residues 1 to 1511) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1511) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1511) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1511) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1511) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11372. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1511 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1511 /product="ATP-binding cassette multidrug transporter PDR12" /calculated_mol_wt="170935" Region 89..1468 /region_name="3a01205" /note="Pleiotropic Drug Resistance (PDR) Family protein; TIGR00956" /db_xref="CDD:273362" CDS 1..1511 /gene="PDR12" /locus_tag="YPL058C" /coded_by="NM_001183872.1:1..4536" /experiment="EXISTENCE:direct assay:GO:0005342 organic acid transmembrane transporter activity [PMID:10419965]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9687494]" /experiment="EXISTENCE:direct assay:GO:0015849 organic acid transport [PMID:10419965]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Plasma membrane ATP-binding cassette (ABC) transporter; weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity" /db_xref="GeneID:856049" /db_xref="SGD:S000005979" ORIGIN 1 msstdehiek dissrsnhdd dyansvqsya asegqvdned laatsqlsrh lsnilsneeg 61 ierlesmarv ishktkkemd sfeindldfd lrsllhylrs rqleqgiepg dsgiafknlt 121 avgvdasaay gpsveemfrn iasipahlis kftkksdvpl rniiqnctgv vesgemlfvv 181 grpgagcstf lkclsgetse lvdvqgefsy dgldqsemms kykgyviycp eldfhfpkit 241 vketidfalk cktprvridk mtrkqyvdni rdmwctvfgl rhtyatkvgn dfvrgvsgge 301 rkrvslveaq amnasiyswd natrgldast alefaqairt atnmvnnsai vaiyqageni 361 yelfdkttvl yngrqiyfgp adkavgyfqr mgwvkpnrmt saefltsvtv dfenrtldik 421 pgyedkvpks ssefeeywln sedyqellrt yddyqsrhpv netrdrldva kkqrlqqgqr 481 ensqyvvnyw tqvyycmirg fqrvkgdsty tkvylssfli kaliigsmfh kiddksqstt 541 agaysrggml fyvllfasvt slaeignsfs srpvivkhks ysmyhlsaes lqeiitefpt 601 kfvaivilcl itywipfmky eagaffqyil ylltvqqcts fifkfvatms ksgvdahavg 661 glwvlmlcvy agfvlpigem hhwirwlhfi npltyafesl vstefhhrem lcsalvpsgp 721 gyegisianq vcdaagavkg nlyvsgdsyi lhqyhfaykh awrnwgvniv wtfgyivfnv 781 ilseylkpve gggdlllykr ghmpelgten adartasree mmealngpnv dlekviaekd 841 vftwnhldyt ipydgatrkl lsdvfgyvkp gkmtalmges gagkttllnv laqrinmgvi 901 tgdmlvnakp lpasfnrscg yvaqadnhma elsvreslrf aaelrqqssv pleekyeyve 961 kiitllgmqn yaealvgktg rglnveqrkk lsigvelvak pslllfldep tsgldsqsaw 1021 sivqfmrala dsgqsilcti hqpsatlfeq fdrllllkkg gkmvyfgdig pnsetllkyf 1081 erqsgmkcgv senpaeyiln cigagatasv nsdwhdlwla specaaarae veelhrtlpg 1141 ravnddpela trfaasymtq ikcvlrrtal qfwrspvyir akffecvaca lfvglsyvgv 1201 nhsvggaiea fssifmllli alaminqlhv faydsrelye vreaasntfh wsvlllchaa 1261 venfwstlcq fmcficyywp aqfsgrasha gfffffyvli fplyfvtygl wilymspdvp 1321 sasminsnlf aamllfcgil qprekmpafw rrlmynvspf tyvvqalvtp lvhnkkvvcn 1381 pheynimdpp sgktcgefls tymdnntgyl vnptatencq ycpytvqdqv vakynvkwdh 1441 rwrnfgfmwa yicfniaaml icyyvvrvkv wslksvlnfk kwfngprker hekdtnifqt 1501 vpgdenkitk k // LOCUS NP_015268 382 aa linear PLN 30-JUN-2025 DEFINITION mannosylinositol phosphorylceramide synthase catalytic subunit SUR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015268 VERSION NP_015268.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183871.1 REFERENCE 1 (residues 1 to 382) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 382) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 382) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 382) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 382) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11373. Method: conceptual translation. FEATURES Location/Qualifiers source 1..382 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..382 /product="mannosylinositol phosphorylceramide synthase catalytic subunit SUR1" /EC_number="2.4.1.370" /calculated_mol_wt="44677" Region 55..184 /region_name="OCH1" /note="Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]; COG3774" /db_xref="CDD:442988" CDS 1..382 /gene="SUR1" /locus_tag="YPL057C" /gene_synonym="BCL21; CSG1; LPE15" /coded_by="NM_001183871.1:1..1149" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:19001347]" /experiment="EXISTENCE:mutant phenotype:GO:0006675 mannosyl-inositol phosphorylceramide metabolic process [PMID:9323360]" /experiment="EXISTENCE:mutant phenotype:GO:0006688 glycosphingolipid biosynthetic process [PMID:9323360]" /experiment="EXISTENCE:mutant phenotype:GO:0030148 sphingolipid biosynthetic process [PMID:12954640]" /experiment="EXISTENCE:mutant phenotype:GO:0103064 inositol phosphorylceramide mannosyltransferase activity [PMID:12954640]" /note="Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication" /db_xref="GeneID:856050" /db_xref="SGD:S000005978" ORIGIN 1 mrkelkylic fnillllsii yytfdlltlc iddtvkdail eedlnpdapp kpqlipkiih 61 qtyktedipe hwkegrqkcl dlhpdykyil wtdemayefi keeypwfldt fenykypier 121 adairyfils hyggvyidld dgcerkldpl lafpaflrkt splgvsndvm gsvprhpffl 181 kalkslkhyd kywfipymti mgstgplfls viwkqykrwr ipkngtvril qpayykmhsy 241 sffsitkgss whlddaklmk alenhilscv vtgfifgffi lygeftfycw lcsknfsnlt 301 knwklnaikv rfvtilnslg lrlklsksts dtasatllar qqkrlrkdsn tnivllkssr 361 ksdvydlekn dsskyslgnn ss // LOCUS NP_015269 101 aa linear PLN 30-JUN-2025 DEFINITION Lcl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015269 VERSION NP_015269.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183870.1 REFERENCE 1 (residues 1 to 101) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 101) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 101) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 101) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 101) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11374. Method: conceptual translation. FEATURES Location/Qualifiers source 1..101 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..101 /product="Lcl1p" /calculated_mol_wt="11200" CDS 1..101 /gene="LCL1" /locus_tag="YPL056C" /coded_by="NM_001183870.1:1..306" /note="hypothetical protein; deletion mutant is fluconazole resistant and has long chronological lifespan" /db_xref="GeneID:856051" /db_xref="SGD:S000005977" ORIGIN 1 mknaalceal pllatcshei pptphtvcfv fppalllsps kltllnsrrv asrcviiidp 61 rllrlfscsr pqqlprdknq sfakpsfsff fflltsllsp f // LOCUS NP_015270 332 aa linear PLN 30-JUN-2025 DEFINITION Lge1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015270 VERSION NP_015270.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183869.1 REFERENCE 1 (residues 1 to 332) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 332) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 332) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 332) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 332) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11375. Method: conceptual translation. FEATURES Location/Qualifiers source 1..332 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..332 /product="Lge1p" /calculated_mol_wt="37178" Region 243..331 /region_name="Lge1" /note="Transcriptional regulatory protein Lge1 and similar proteins; cd22897" /db_xref="CDD:439378" CDS 1..332 /gene="LGE1" /locus_tag="YPL055C" /coded_by="NM_001183869.1:1..999" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:32214243|PMID:14562095|PMID:15528187]" /experiment="EXISTENCE:direct assay:GO:0140693 molecular condensate scaffold activity [PMID:32214243]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:18069899]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:12089449]" /experiment="EXISTENCE:mutant phenotype:GO:0031509 subtelomeric heterochromatin formation [PMID:37431950]" /experiment="EXISTENCE:physical interaction:GO:0140693 molecular condensate scaffold activity [PMID:32214243]" /note="Protein that facilitates co-transcriptional histone H2B ubiquitination; scaffold protein that promotes oligomerization of E3 ligase Bre1p; contains an intrinsically disordered region that phase separates, to form a core encapsulated by Bre1p that recruits Ub-conjugating enzyme Rad6p, elevating catalytic activity along gene bodies; null mutant forms abnormally large cells, and homozygous null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division" /db_xref="GeneID:856052" /db_xref="SGD:S000005976" ORIGIN 1 msgytgnnys rysstpprqr ggyhharrsr ggaggsyyrg gnasygaryn sdyeqppqeg 61 dlrqtgayyr ngytdtrpyy sansrhyqaq psprynngtn syhlpqrgns qdtngrttsa 121 sqedndekrv ksryrnmqad hprqqpmsvg stssrngssg nsstsstsng lppppsvssi 181 tnnrsyhssa ypyssshtyn nyhhretppp ppsngyyakg ypvhvpenrs nsdgssssvv 241 kkkrildmkd spfiyltdfd knvkktnnte secekarevf kesdsidsal eelnlkinsn 301 elelrllnnq cdkhalniql tqekldslll mq // LOCUS NP_015271 301 aa linear PLN 30-JUN-2025 DEFINITION Lee1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015271 VERSION NP_015271.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183868.1 REFERENCE 1 (residues 1 to 301) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 301) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 301) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 301) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11376. Method: conceptual translation. FEATURES Location/Qualifiers source 1..301 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..301 /product="Lee1p" /calculated_mol_wt="33465" Region 1..301 /region_name="YTH1" /note="Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]; COG5084" /db_xref="CDD:227416" CDS 1..301 /gene="LEE1" /locus_tag="YPL054W" /coded_by="NM_001183868.1:1..906" /note="Zinc-finger hypothetical protein" /db_xref="GeneID:856053" /db_xref="SGD:S000005975" ORIGIN 1 mdafenmsvs nhpggnarrn sqsanemlas qiqdfqnipr sfndsnanvn lsknctvgnq 61 lpfssrqqki imehllitkn nsqqqkdysh vpckffkmgn cqagsscpfs hspdiissan 121 nlpckyfakg nckfgnkcvn ahvlpngfkm nskepiditp psqnnylsha rsasfstyts 181 pplsaqtefs hsasnanyfs sqylmyspqk spealyteff sppsssssyi nysynnsnin 241 ayspvsssss niwqeqgqtt lsnpsvnqnl ryrtgpaiqe esdneiedll ihnfnsrych 301 e // LOCUS NP_015272 446 aa linear PLN 30-JUN-2025 DEFINITION putative mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015272 VERSION NP_015272.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183867.1 REFERENCE 1 (residues 1 to 446) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 446) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 446) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 446) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 446) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11377. Method: conceptual translation. FEATURES Location/Qualifiers source 1..446 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..446 /product="putative mannosyltransferase" /calculated_mol_wt="51997" Region 7..443 /region_name="KTR1" /note="Mannosyltransferase [Carbohydrate transport and metabolism]; COG5020" /db_xref="CDD:227353" CDS 1..446 /gene="KTR6" /locus_tag="YPL053C" /gene_synonym="MNN6" /coded_by="NM_001183867.1:1..1341" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:30842360]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9218445]" /experiment="EXISTENCE:mutant phenotype:GO:0000031 mannosylphosphate transferase activity [PMID:9218445]" /experiment="EXISTENCE:mutant phenotype:GO:0006487 protein N-linked glycosylation [PMID:9218445]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:30842360]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:9090056]" /note="Probable mannosylphosphate transferase; involved in the synthesis of core oligosaccharides in protein glycosylation pathway; facilitates the exit of Mnn4p from the ER via COPII-coated vesicles; member of the KRE2/MNT1 mannosyltransferase family; KTR6 has a paralog, KRE2, that arose from the whole genome duplication" /db_xref="GeneID:856054" /db_xref="SGD:S000005974" ORIGIN 1 mhvllskkia rfllisfvfv lalmvtinhp ktkqmseqyv tpylpkslqp iakisaeeqr 61 riqseqeeae lkqslegeai rnatvnaike kiksyggnet tlgfmvpsyi nhrgsppkac 121 fvsliterds mtqilqside vqvkfnknfa ypwvfisqge ldgmkqemir qaitdsmngd 181 pelinikfae ipadewvype widenkaaes lislanvpdg dsravryqar yfagffwrhp 241 vldefdwywr vdpgiklycd idhdlfrwmq degkvfgftl smseakeane kiwdvtkkfa 301 kdfpkfisen nfksfitkkd sedfnnceft snfeignlnf yrspayrkff nyideeggif 361 ywkwsdsiih tiglsmllpk dkihffenig fhydkynncp lnddiwnqyn cncdqgndft 421 frsgscgghy fdimkkdkpe gwdrlp // LOCUS NP_015273 292 aa linear PLN 30-JUN-2025 DEFINITION Oaz1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015273 VERSION NP_015273.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183866.4 REFERENCE 1 (residues 1 to 292) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 292) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 292) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 292) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 292) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11378. On Dec 19, 2005 this sequence version replaced NP_015273.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..292 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..292 /product="Oaz1p" /calculated_mol_wt="33914" CDS 1..292 /gene="OAZ1" /locus_tag="YPL052W" /gene_synonym="YPL052W-A" /coded_by="join(NM_001183866.4:1..207, NM_001183866.4:209..880)" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:15538383]" /experiment="EXISTENCE:direct assay:GO:0008073 ornithine decarboxylase inhibitor activity [PMID:15538383]" /experiment="EXISTENCE:direct assay:GO:0061136 regulation of proteasomal protein catabolic process [PMID:18089576]" /experiment="EXISTENCE:mutant phenotype:GO:2001125 negative regulation of translational frameshifting [PMID:21900894]" /ribosomal_slippage="" /note="Regulator of ornithine decarboxylase Spe1p; antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing translation of full-length Oaz1p" /db_xref="GeneID:856055" /db_xref="SGD:S000005973" ORIGIN 1 myeviqkrkt kiinvlqspe lmrliedpsn lgislhfpvs sllksnkctp mpklstysla 61 sggfkdwcad ipldvppeid iidfywdvil cmesqfildy nvpsknkgnn qksvakllkn 121 klvndmkttl krliynentk qyknnnshdg ynwrklgsqy filylplftq eliwcklnen 181 yfhvvlpsll nsrnvhdnhs tyinkdwlla lleltsnlnq nfkfeymklr lyilrddlin 241 ngldllknln wvggklikne drevllnstd latdsishll gdenfvilef ec // LOCUS NP_015274 198 aa linear PLN 30-JUN-2025 DEFINITION Arf family GTPase ARL3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015274 VERSION NP_015274.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183865.1 REFERENCE 1 (residues 1 to 198) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 198) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 198) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 198) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 198) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11379. Method: conceptual translation. FEATURES Location/Qualifiers source 1..198 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..198 /product="Arf family GTPase ARL3" /calculated_mol_wt="22651" Region 19..185 /region_name="Arfrp1" /note="Arf-related protein 1 (Arfrp1); cd04160" /db_xref="CDD:206725" Site 24..31 /site_type="other" /note="G1 box" /db_xref="CDD:206725" Site order(26..32,53..54,77,133..134,136,168..170) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206725" Site order(26..27,31,35,53..60,83,88) /site_type="other" /note="putative GAP interaction site [polypeptide binding]" /db_xref="CDD:206725" Site order(36..39,47..57) /site_type="other" /note="Switch I region" /db_xref="CDD:206725" Site order(54..58,63,74,78,84,86..88) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206725" Site 54 /site_type="other" /note="G2 box" /db_xref="CDD:206725" Site order(55..62,73,84,87..88) /site_type="active" /note="putative effector interaction site [active]" /db_xref="CDD:206725" Site order(58..64,68..73) /site_type="active" /note="interswitch region [active]" /db_xref="CDD:206725" Site 74..91 /site_type="other" /note="Switch II region" /db_xref="CDD:206725" Site 74..77 /site_type="other" /note="G3 box" /db_xref="CDD:206725" Site 133..136 /site_type="other" /note="G4 box" /db_xref="CDD:206725" Site 168..170 /site_type="other" /note="G5 box" /db_xref="CDD:206725" CDS 1..198 /gene="ARL3" /locus_tag="YPL051W" /coded_by="NM_001183865.1:1..597" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:9920936]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:15077114|PMID:15077113]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:9920936]" /experiment="EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:9920936]" /experiment="EXISTENCE:mutant phenotype:GO:0034067 protein localization to Golgi apparatus [PMID:26966233|PMID:12620189]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:26966233]" /experiment="EXISTENCE:mutant phenotype:GO:0043001 Golgi to plasma membrane protein transport [PMID:16926193]" /note="ARF-like small GTPase of the RAS superfamily; required for recruitment of Arl1p, a GTPase that regulates membrane traffic, to the Golgi apparatus; NatC-catalyzed N-terminal acetylation regulates Golgi membrane association mediated by interaction with membrane receptor, Sys1p; similar to ADP-ribosylation factor and orthologous to mammalian ARFRP1" /db_xref="GeneID:856056" /db_xref="SGD:S000005972" ORIGIN 1 mfhlvkglyn nwnkkeqysi lilgldnagk ttfletlkke yslafkalek iqptvgqnva 61 tipvdskqil kfwdvggqes lrsmwseyys lchgiifivd ssdrerldec sttlqsvvmd 121 eeiegvpilm lankqdrqdr mevqdikevf nkiaehisar dsrvlpisal tgegvkdaie 181 wmivrlernk ksrppiyk // LOCUS NP_015275 395 aa linear PLN 30-JUN-2025 DEFINITION mannosyltransferase complex subunit MNN9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015275 VERSION NP_015275.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183864.1 REFERENCE 1 (residues 1 to 395) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 395) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 395) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 395) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 395) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11380. Method: conceptual translation. FEATURES Location/Qualifiers source 1..395 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..395 /product="mannosyltransferase complex subunit MNN9" /calculated_mol_wt="45824" Region 95..358 /region_name="Anp1" /note="pfam03452" /db_xref="CDD:427303" CDS 1..395 /gene="MNN9" /locus_tag="YPL050C" /coded_by="NM_001183864.1:1..1188" /experiment="EXISTENCE:direct assay:GO:0000009 alpha-1,6-mannosyltransferase activity [PMID:19249370]" /experiment="EXISTENCE:direct assay:GO:0000136 mannan polymerase complex [PMID:9430634]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005801 cis-Golgi network [PMID:9430634]" /experiment="EXISTENCE:direct assay:GO:0006487 protein N-linked glycosylation [PMID:19249370|PMID:9430634]" /note="Subunit of Golgi mannosyltransferase complex; this complex mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation; this complex also contains Anp1p, Mnn10p, Mnn11p, and Hoc1p" /db_xref="GeneID:856057" /db_xref="SGD:S000005971" ORIGIN 1 mslslvsyrl rknpwvnifl pvlaifliyi iffqrdqsll glngqsisqh kwahekentf 61 yfpftkkykm pkysykkksg wlfndhvedi ipeghiahyd lnklhstsea avnkehilil 121 tpmqtfhqqy wdnllqlnyp relielgfit prtatgdlal kklenaikkv qtdkktqrfs 181 kitilrqnsq sfdklmeker haldvqkerr aamalarnel lfstigphts wvlwldadii 241 etppsliqdm tkhnkailaa niyqrfydee kkqpsirpyd fnnwqesdtg leiasqmgdd 301 eiivegyaei atyrplmahf ydangvpgee maldgvgggc tlvkaevhrd gamfpnfpfy 361 hlietegfak makrlnydvf glpnylvyhi eeenh // LOCUS NP_015276 452 aa linear PLN 30-JUN-2025 DEFINITION Dig1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015276 VERSION NP_015276.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183863.1 REFERENCE 1 (residues 1 to 452) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 452) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 452) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 452) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 452) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11381. Method: conceptual translation. FEATURES Location/Qualifiers source 1..452 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..452 /product="Dig1p" /calculated_mol_wt="49225" CDS 1..452 /gene="DIG1" /locus_tag="YPL049C" /gene_synonym="RST1" /coded_by="NM_001183863.1:1..1359" /experiment="EXISTENCE:direct assay:GO:0003714 transcription corepressor activity [PMID:10825185]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:8918885|PMID:9094309]" /experiment="EXISTENCE:direct assay:GO:1990526 Ste12p-Dig1p-Dig2p complex [PMID:16782869]" /experiment="EXISTENCE:direct assay:GO:1990527 Tec1p-Ste12p-Dig1p complex [PMID:16782869]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9094309|PMID:9860980]" /experiment="EXISTENCE:genetic interaction:GO:0071444 cellular response to pheromone [PMID:9860980|PMID:9094309]" /experiment="EXISTENCE:genetic interaction:GO:2000218 negative regulation of invasive growth in response to glucose limitation [PMID:8918885|PMID:9094309]" /experiment="EXISTENCE:genetic interaction:GO:2000221 negative regulation of pseudohyphal growth [PMID:9094309|PMID:8918885]" /note="MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG1 has a paralog, DIG2, that arose from the whole genome duplication" /db_xref="GeneID:856058" /db_xref="SGD:S000005970" ORIGIN 1 mavsarlrtt aedtsiakst qdpigdteis vanakgssds niknspggns vgqeselehv 61 peeddsgdke adhedsetat akkrkaqplk npkkslkrgr vpaplnlsds ntnthggnik 121 dgnlassnsa hfppvanqnv ksapaqvtqh skfqprvqyl gkassrqsiq vnnssnsygk 181 phmpsagims amnpympmnr yimspyynpy gippphmlnk pimtpyvsyp ypmgprtsip 241 yamqggnarp yeeneysasn yrnkrvndsy dsplsgtast gktrrseegs rnssvgssan 301 agptqqradl rpadmipaee yhferdalls antkarsast ststststnr drsswheaep 361 nkdeeegtdl aiedgavptp tfttfqrtsq pqqqspsllq geirlsshif afefplsssn 421 vdkkmfmsic nkvwneskel tkkssshhrt gk // LOCUS NP_015277 415 aa linear PLN 30-JUN-2025 DEFINITION translation elongation factor EF1B gamma [Saccharomyces cerevisiae S288C]. ACCESSION NP_015277 VERSION NP_015277.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183862.1 REFERENCE 1 (residues 1 to 415) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 415) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 415) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 415) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 415) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11382. Method: conceptual translation. FEATURES Location/Qualifiers source 1..415 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..415 /product="translation elongation factor EF1B gamma" /calculated_mol_wt="46957" Region 4..73 /region_name="GST_N_EF1Bgamma" /note="GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of...; cd03044" /db_xref="CDD:239342" Site order(12,15,18..19,22,64) /site_type="other" /note="C-terminal domain interface [polypeptide binding]" /db_xref="CDD:239342" Site order(13,48..50,62..63) /site_type="other" /note="putative GSH binding site (G-site) [chemical binding]" /db_xref="CDD:239342" Site order(48,61..62,64..65,68) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:239342" Region 92..214 /region_name="GST_C_EF1Bgamma_like" /note="Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins; cd03181" /db_xref="CDD:198290" Site order(97..98,101..102,105,142) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:198290" Site order(104,167,171,200,203..205) /site_type="other" /note="N-terminal domain interface [polypeptide binding]" /db_xref="CDD:198290" Region 255..359 /region_name="EF1G" /note="Elongation factor 1 gamma, conserved domain; pfam00647" /db_xref="CDD:459888" CDS 1..415 /gene="CAM1" /locus_tag="YPL048W" /gene_synonym="TEF3" /coded_by="NM_001183862.1:1..1248" /experiment="EXISTENCE:direct assay:GO:0001046 core promoter sequence-specific DNA binding [PMID:12824466]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:3528160]" /experiment="EXISTENCE:direct assay:GO:0005509 calcium ion binding [PMID:8465602]" /experiment="EXISTENCE:direct assay:GO:0005543 phospholipid binding [PMID:8465602]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12824466]" /experiment="EXISTENCE:direct assay:GO:0006414 translational elongation [PMID:3528160]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:genetic interaction:GO:0006449 regulation of translational termination [PMID:19545407]" /experiment="EXISTENCE:mutant phenotype:GO:0003700 DNA-binding transcription factor activity [PMID:12824466]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:12824466]" /note="One of two isoforms of the gamma subunit of eEF1B; stimulates the release of GDP from eEF1A (Tef1p/Tef2p) post association with the ribosomal complex with eEF1Balpha subunit; nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids" /db_xref="GeneID:856059" /db_xref="SGD:S000005969" ORIGIN 1 msqgtlyanf rirtwvprgl vkalkldvkv vtpdaaaeqf ardfplkkvp afvgpkgykl 61 teamainyyl vklsqddkmk tqllgadddl naqaqiirwq slansdlciq iantivplkg 121 gapynkksvd samdavdkiv difenrlkny tylatenisl adlvaasift ryfeslfgte 181 wraqhpaivr wfntvraspf lkdeykdfkf adkplsppqk kkekkapaaa paaskkkeea 241 kpaatetets skkpkhplel lgkstfvldd wkrkysnedt rpvalpwfwe hynpeeyslw 301 kvtykyndel tltfmsnnlv ggffnrlsas tkymfgclvv ygennnngiv gavmvrgqdy 361 vpafdvapdw esydyakldp tndddkefin nmwawdkpvs vngepkeivd gkvlk // LOCUS NP_015278 99 aa linear PLN 30-JUN-2025 DEFINITION SAGA histone acetyltransferase complex subunit SGF11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015278 VERSION NP_015278.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183861.1 REFERENCE 1 (residues 1 to 99) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 99) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 99) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 99) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11383. Method: conceptual translation. FEATURES Location/Qualifiers source 1..99 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..99 /product="SAGA histone acetyltransferase complex subunit SGF11" /calculated_mol_wt="11154" Region 6..44 /region_name="Sgf11_N" /note="SAGA-associated factor 11 N-terminal domain; pfam18519" /db_xref="CDD:408308" Region 67..99 /region_name="Sgf11" /note="Sgf11 (transcriptional regulation protein); pfam08209" /db_xref="CDD:369754" CDS 1..99 /gene="SGF11" /locus_tag="YPL047W" /coded_by="NM_001183861.1:1..300" /experiment="EXISTENCE:direct assay:GO:0000124 SAGA complex [PMID:15282323]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:18488019]" /experiment="EXISTENCE:direct assay:GO:0071819 DUBm complex [PMID:20395473]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:15282323]" /note="Integral subunit of SAGA histone acetyltransferase complex; regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation" /db_xref="GeneID:856060" /db_xref="SGD:S000005968" ORIGIN 1 mteetitids isngilnnll ttliqdivar ettqqqllkt rypdlrsyyf dpngslding 61 lqkqqessqy ihcencgrdv sanrlaahlq rclsrgarr // LOCUS NP_015279 99 aa linear PLN 30-JUN-2025 DEFINITION elongin C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015279 VERSION NP_015279.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183860.1 REFERENCE 1 (residues 1 to 99) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 99) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 99) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 99) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 99) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11384. Method: conceptual translation. FEATURES Location/Qualifiers source 1..99 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..99 /product="elongin C" /calculated_mol_wt="11197" Region 5..99 /region_name="BTB_POZ_EloC" /note="BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins; cd18321" /db_xref="CDD:349630" Site order(5,12..19,50..52,55,58..59,62..63,66..67,78..80, 84..86,88..89) /site_type="other" /note="elongin B interface [polypeptide binding]" /db_xref="CDD:349630" Site order(31..32,34,36..39,43..45,47..48,92,95..96) /site_type="other" /note="cullin binding site [polypeptide binding]" /db_xref="CDD:349630" Site order(60,64,67,70,76..77,79..80,82,84,87..88,90..92,94..95, 99) /site_type="other" /note="target protein binding site [polypeptide binding]" /db_xref="CDD:349630" CDS 1..99 /gene="ELC1" /locus_tag="YPL046C" /coded_by="NM_001183860.1:1..300" /experiment="EXISTENCE:direct assay:GO:0000113 nucleotide-excision repair factor 4 complex [PMID:15226437]" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:16675952]" /experiment="EXISTENCE:direct assay:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:16675952]" /experiment="EXISTENCE:mutant phenotype:GO:0006511 ubiquitin-dependent protein catabolic process [PMID:16705154]" /experiment="EXISTENCE:mutant phenotype:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:17296727]" /experiment="EXISTENCE:mutant phenotype:GO:0070911 global genome nucleotide-excision repair [PMID:18817898]" /experiment="EXISTENCE:physical interaction:GO:0031463 Cul3-RING ubiquitin ligase complex [PMID:16675952]" /experiment="EXISTENCE:physical interaction:GO:0070449 elongin complex [PMID:10753924|PMID:10430890]" /note="Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair" /db_xref="GeneID:856061" /db_xref="SGD:S000005967" ORIGIN 1 msqdfvtlvs kddkeyeisr saamisptlk amiegpfres kgrielkqfd shilekavey 61 lnynlkysgv sedddeipef eiptemslel llaadylsi // LOCUS NP_015280 798 aa linear PLN 30-JUN-2025 DEFINITION tethering complex subunit VPS16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015280 VERSION NP_015280.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183859.1 REFERENCE 1 (residues 1 to 798) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 798) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 798) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 798) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 798) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 798) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 798) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11385. Method: conceptual translation. FEATURES Location/Qualifiers source 1..798 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..798 /product="tethering complex subunit VPS16" /calculated_mol_wt="92611" Region 4..379 /region_name="Vps16_N" /note="Vps16, N-terminal region; pfam04841" /db_xref="CDD:252829" Region 478..798 /region_name="Vps16_C" /note="Vps16, C-terminal region; pfam04840" /db_xref="CDD:282668" CDS 1..798 /gene="VPS16" /locus_tag="YPL045W" /gene_synonym="CVT15; SVL6; VAM9; VPT16" /coded_by="NM_001183859.1:1..2397" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:9362071|PMID:10944212]" /experiment="EXISTENCE:direct assay:GO:0033263 CORVET complex [PMID:17488625]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:16601699]" /experiment="EXISTENCE:direct assay:GO:0035542 regulation of SNARE complex assembly [PMID:18385512]" /experiment="EXISTENCE:direct assay:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:direct assay:GO:0099022 vesicle tethering [PMID:27307091]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:9362071]" /experiment="EXISTENCE:mutant phenotype:GO:0006895 Golgi to endosome transport [PMID:11422941]" /experiment="EXISTENCE:mutant phenotype:GO:0007033 vacuole organization [PMID:9362071]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:10944212]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:11422941]" /experiment="EXISTENCE:physical interaction:GO:0030897 HOPS complex [PMID:10944212]" /note="Subunit of the HOPS and the CORVET complexes; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages" /db_xref="GeneID:856062" /db_xref="SGD:S000005966" ORIGIN 1 mknpsfdwer lkdvfyrsra igelkwptqy eefkcalslt viaveiqdfi qvynyfgqll 61 gkinlqrihe diikfefdkd eklilvtkss ikivkgwspl tiesvplqdp tidtiwdyhn 121 gimllaksrd iyklngnewe llyenkdkky nlltknhwsc nddsiilldv dhvyqvstsn 181 gallklitds swhkvtissr gficlynmkd nklqifrdpa rilmehnlds tpddicwcgn 241 dtvacsfede iklygpdgly vtfwypftvt nlraevdglk vittekiyfl srvqpqtsni 301 frigstepga mlvdsfslle dhapkaieil knfvlekgvl dciaaaidef epklqkmlln 361 aasygkaslq yksfdasifv nacntiklln cfrsfgiflt veeyrcislk gvidrllkyh 421 ryyeciqick lanerfllgy vftewakdki kgspdmedde lldkiksrls vidmtdtlqm 481 vavakvayle grfqlsrnla llekneeari eqlynlddds ialkecikvq nysltislli 541 alskkltnsq ltklliidmf nnplylyymr mdkaylydfy rqtdrfidla hvllqqgkeq 601 qslhsflpqi kdlysqvqns evvnntieql qrqeklwiyq eslgkrfais ftnmtldqtl 661 sklietgqdk qvkeivkkfk isekklyhlk cktlveakkf dellqfaqsr kspigympfy 721 tylksrghmd kaspyvnmip glsyqekkkl yvecrgfrda iqlagkekdi pglkeiynii 781 ppnepelkal anetmsri // LOCUS NP_015282 685 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding ribosome biosynthesis protein NOP4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015282 VERSION NP_015282.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183857.1 REFERENCE 1 (residues 1 to 685) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 685) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 685) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 685) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 685) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11386. Method: conceptual translation. FEATURES Location/Qualifiers source 1..685 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..685 /product="mRNA-binding ribosome biosynthesis protein NOP4" /calculated_mol_wt="77694" Region 26..104 /region_name="RRM1_Nop4p" /note="RNA recognition motif 1 (RRM1) found in yeast nucleolar protein 4 (Nop4p) and similar proteins; cd12674" /db_xref="CDD:410075" Region 147..229 /region_name="RRM2_Nop4p" /note="RNA recognition motif 2 (RRM2) found in yeast nucleolar protein 4 (Nop4p) and similar proteins; cd12675" /db_xref="CDD:410076" Region 289..387 /region_name="RRM3_Nop4p" /note="RNA recognition motif 3 (RRM3) found in yeast nucleolar protein 4 (Nop4p) and similar proteins; cd12676" /db_xref="CDD:410077" Region 458..620 /region_name="RRM4_Nop4p" /note="RNA recognition motif 4 (RRM4) found in yeast nucleolar protein 4 (Nop4p) and similar proteins; cd12677" /db_xref="CDD:410078" CDS 1..685 /gene="NOP4" /locus_tag="YPL043W" /gene_synonym="NOP77" /coded_by="NM_001183857.1:1..2058" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:8039505]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:8039505]" /note="Nucleolar protein; essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs); human ortholog RBM28 implicated in ANE syndrome" /db_xref="GeneID:856063" /db_xref="SGD:S000005964" ORIGIN 1 meetienvev pssnvskqnd dgldmktlfv rsipqdvtde qladffsnfa pikhavvvkd 61 tnkrsrgfgf vsfaveddtk ealakarktk fnghilrvdi akrrdrskkt sevvekstpe 121 ssekitgqnn ededdadged smlkgkpkli irnmpwscrd pvklkkifgr ygtvveatip 181 rkrdgklcgf afvtmkkisn crialentkd lkidgrkvav dfavqknrwe dykkaqpemn 241 dkddnesgne daeenhddee deneeedrqv dqasknkesk rkaqnkredf svfvrnvpyd 301 ateeslaphf skfgsvkyal pvidkstgla kgtafvafkd qytynecikn apaagstsll 361 igddvmpeyv yegrvlsitp tlvredagrm aeknaakrke algkapgekd rrnlyllneg 421 rvvegskmad lltntdmeir eksyklrveq lkknpslhls mtrlairnlp ramndkalka 481 larkavvefa tevknkerhp lskeeiirst kekykfmgpd eieaqkkkdk ksgvvkqakv 541 imevkgstag rsrgygfvef rdhknalmgl rwlnchavts deileglndd ekkqvdndlg 601 kgrrlcvefa iensnvvkrr reqlkqartk rtrpdnedtg dvgesenkkp kkeeattptn 661 pddkkmgddi kriigfkrkr khakk // LOCUS NP_015283 555 aa linear PLN 30-JUN-2025 DEFINITION cyclin-dependent serine/threonine protein kinase SSN3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015283 VERSION NP_015283.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183856.1 REFERENCE 1 (residues 1 to 555) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 555) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 555) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 555) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 555) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11387. Method: conceptual translation. FEATURES Location/Qualifiers source 1..555 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..555 /product="cyclin-dependent serine/threonine protein kinase SSN3" /EC_number="2.7.11.22" /EC_number="2.7.11.23" /calculated_mol_wt="62716" Region 74..463 /region_name="STKc_CDK8_like" /note="Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; cd07842" /db_xref="CDD:270834" Site order(81..84,89,181,183,206,220,236..239,242,244..245,286, 288,290..291,293,304,307,322,324..327,329,367..368) /site_type="active" /db_xref="CDD:270834" Site order(81..84,89,181,183,220,236..239,242,245,290..291,293, 304) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270834" Site order(199..200,202,205..206,208..210,212..214,225,227, 230..232,280..282) /site_type="other" /note="CDK/cyclin interface [polypeptide binding]" /db_xref="CDD:270834" Site order(206,244,286,288,307,322,324..327,329,367..368) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270834" Site order(303..316,318..329) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270834" CDS 1..555 /gene="SSN3" /locus_tag="YPL042C" /gene_synonym="CDK8; GIG2; NUT7; RYE5; SRB10; SSX7; UME5; URR1" /coded_by="NM_001183856.1:1..1668" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:11331604]" /experiment="EXISTENCE:direct assay:GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity [PMID:9702190]" /experiment="EXISTENCE:direct assay:GO:0016592 mediator complex [PMID:11383511|PMID:12200444]" /experiment="EXISTENCE:genetic interaction:GO:0060258 negative regulation of filamentous growth [PMID:12520306]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16109375]" /experiment="EXISTENCE:mutant phenotype:GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity [PMID:9702190]" /experiment="EXISTENCE:mutant phenotype:GO:0031648 protein destabilization [PMID:12520306]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:15601835]" /experiment="EXISTENCE:mutant phenotype:GO:0060258 negative regulation of filamentous growth [PMID:12520306]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:17660569]" /experiment="EXISTENCE:physical interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11226276]" /note="Component of the RNA polymerase II mediator complex; cyclin-dependent protein kinase involved in phosphorylation of the mediator component Pgd1p and suppression of transcription activation by RNA polymerase II; involved in glucose repression" /db_xref="GeneID:856065" /db_xref="SGD:S000005963" ORIGIN 1 myngkdraqn syqpmyqrpm qvqgqqqaqs fvgkkntigs vhgkapmlma nndvftigpy 61 rarkdrmrvs vlekyevigy iaagtygkvy kakrqinsgt nsangsslng tnakipqfds 121 tqpkssssmd mqantnalrr nllkdegvtp grirttredv sphynsqkqt likkpltvfy 181 aikkfktekd gveqlhytgi sqsacremal crelhnkhlt tlveiflerk cvhmvyeyae 241 hdllqiihfh shpekrmipp rmvrsimwql ldgvsylhqn wvlhrdlkpa nimvtidgcv 301 kigdlglark fhnmlqtlyt gdkvvvtiwy rapelllgar hytpavdlws vgcifaelig 361 lqpifkgeea kldskktvpf qvnqlqrile vlgtpdqkiw pylekypeyd qitkfpkyrd 421 nlatwyhsag grdkhalsll yhllnydpik ridafnaleh kyftesdipv senvfeglty 481 kyparrihtn dndimnlgsr tknntqasgi tagaaanalg glgvnrrila aaaaaaaavs 541 gnnasdepsr kknrr // LOCUS NP_015284 207 aa linear PLN 30-JUN-2025 DEFINITION Mrx11p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015284 VERSION NP_015284.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183855.1 REFERENCE 1 (residues 1 to 207) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 207) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 207) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 207) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 207) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11388. Method: conceptual translation. FEATURES Location/Qualifiers source 1..207 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..207 /product="Mrx11p" /calculated_mol_wt="24035" Region 69..147 /region_name="FLILHELTA" /note="Hypothetical protein FLILHELTA; pfam10306" /db_xref="CDD:431208" CDS 1..207 /gene="MRX11" /locus_tag="YPL041C" /coded_by="NM_001183855.1:1..624" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:26928762]" /note="Protein that associates with mitochondrial ribosome; SWAT-GFP and mCherry fusion proteins localize to the mitochondria; involved in maintenance of telomere length" /db_xref="GeneID:856066" /db_xref="SGD:S000005962" ORIGIN 1 mtvmnlffrp cqlqmgsgpl elmlkrptql ttfmntrpgg stqirfisgn ldpvkrredr 61 lrkifsksrl ltrlnknpkf shyfdrlsea gtvptltsff ilhevtailp lfllwwllyn 121 ldlsddfklp nflnglmdsc htamekfvgk ryqeclnknk lilsgtvayv tvkllypvri 181 fisiwgapyf gkwlllpfqk lkhlikk // LOCUS NP_015285 1002 aa linear PLN 30-JUN-2025 DEFINITION isoleucine--tRNA ligase ISM1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015285 VERSION NP_015285.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183854.1 REFERENCE 1 (residues 1 to 1002) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1002) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1002) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1002) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1002) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1002) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1002) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11389. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1002 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1002 /product="isoleucine--tRNA ligase ISM1" /EC_number="6.1.1.5" /calculated_mol_wt="115663" Region 35..920 /region_name="ileS" /note="isoleucyl-tRNA synthetase; TIGR00392" /db_xref="CDD:273054" CDS 1..1002 /gene="ISM1" /locus_tag="YPL040C" /coded_by="NM_001183854.1:1..3009" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:7607232]" /experiment="EXISTENCE:mutant phenotype:GO:0032543 mitochondrial translation [PMID:7607232]" /note="Mitochondrial isoleucyl-tRNA synthetase; null mutant is deficient in respiratory growth; human homolog IARS2 implicated in mitochondrial diseases, can partially complement yeast null mutant" /db_xref="GeneID:856067" /db_xref="SGD:S000005961" ORIGIN 1 mkrsrlvpqh ifsiiskryl akhayqktln lpktkfpnrs nleitlreli pkssqlvyke 61 qlrdffeefs klnttdekle fikeklfilh dgppyangel hlghalnkil kdiinryqls 121 qgkyifykpg wdchglpiei kalkdlsaqq iesisplkir smalkhaqka ikrqretfqh 181 failtdwetp yltmdkdyei nqlnifkemy erglikrqnk pvywgtetrt alaegeleyn 241 enhksiaayv kfplekksqm dlckklgitn nlpiycliwt stpwtllsnr aicfnqdfsy 301 sllrlnseli lvetgsidkl glttnsfeti kqfqgthlng lyyqnllvdd kvgrpllhga 361 hvtsgtgtgl vhtapghgqd dyligiqngl eiyspvdhqg ryqlnelpqs vrsivrdegd 421 ltkgrqvlda etakiilckl sdlnllyksh eythsypydw rskkpviira tpqwfadlhd 481 vknlalesis rvkfcpkrgy srlssfmksr newcisrqrs wgipilsfyk ksepdsvlmn 541 seilahaiek ikqkginawf ndkdndmkew lpekyhdvah eycrsqdtmd vwfdsgssws 601 vikdfyeksl klsklpsply qvclegsdqh rgwfqssllt kvassnvpva pyeevithgf 661 tldenglkms ksvgntispe aiirgdenlg lpalgvdglr yliaqsnftt divagptvmk 721 hvgealkkvr ltfryllsnl qksqdfnllp ieqlrrvdqy tlykinelle ttrehyqkyn 781 fskvlitlqy hlnnelsafy fdiskdilys nqisslarrq vqttlvhiln ayrailapil 841 pvmvqevwky ipegwlqgqe hidinpmrgk wpfldsntei vtsfenfelk ilkqfqeefk 901 rlsleegvtk tthshvtift khhlpfssde lcdilqssav dilqmddnnn slptielgsg 961 invqilvers krhncprcwk ansaeedklc drckeavdhl ms // LOCUS NP_015286 316 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL039W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015286 VERSION NP_015286.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183853.1 REFERENCE 1 (residues 1 to 316) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 316) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 316) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 316) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 316) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11390. Method: conceptual translation. FEATURES Location/Qualifiers source 1..316 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..316 /product="uncharacterized protein" /calculated_mol_wt="35984" CDS 1..316 /locus_tag="YPL039W" /coded_by="NM_001183853.1:1..951" /note="hypothetical protein; YPL039W is not an essential gene" /db_xref="GeneID:856068" /db_xref="SGD:S000005960" ORIGIN 1 mlkeeynlsg adnmasaels fkkqkvvlkk fmiaqvtkgi mqryasllvt mpsdddnaii 61 gtnhlkttkf leiilhraks shlqfkkvcc ivikfldccs ketnymkflk fslhklfvaa 121 filsvpnvvg ddrdrittrd etyhlysqit glpleevinc csivrpvlir rsrqqrrqml 181 srreqhsyfl rssfmnsnss aspffstnrs addlhvhtra yslhshsdge gqdrrsehee 241 thsmgadadt yrqttfipdt pnglhsrsli ecgieptqvs dsgewsgqsn gyvlvtelqe 301 fnkmgkklvq eafriv // LOCUS NP_878182 63 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL038W-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878182 VERSION NP_878182.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184580.1 REFERENCE 1 (residues 1 to 63) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 63) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 63) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 63) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 63) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11391. Method: conceptual translation. FEATURES Location/Qualifiers source 1..63 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..63 /product="uncharacterized protein" /calculated_mol_wt="7548" CDS 1..63 /locus_tag="YPL038W-A" /coded_by="NM_001184580.1:1..192" /note="hypothetical protein; identified by fungal homology and RT-PCR" /db_xref="GeneID:1466521" /db_xref="SGD:S000028588" ORIGIN 1 mvcrfvhhsr vifisiydfl stkgkknmyn ytqekktkqk ntftqasiyy enffesyrti 61 scl // LOCUS NP_015287 177 aa linear PLN 30-JUN-2025 DEFINITION Met31p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015287 VERSION NP_015287.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183852.1 REFERENCE 1 (residues 1 to 177) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 177) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 177) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 177) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 177) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11392. Method: conceptual translation. FEATURES Location/Qualifiers source 1..177 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..177 /product="Met31p" /calculated_mol_wt="19426" Region <75..>166 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 97..117 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 125..144 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..177 /gene="MET31" /locus_tag="YPL038W" /coded_by="NM_001183852.1:1..534" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9799240]" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:9199298]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9199298]" /experiment="EXISTENCE:direct assay:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:9199298]" /experiment="EXISTENCE:genetic interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9799240]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9199298]" /experiment="EXISTENCE:genetic interaction:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:9199298]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:22696683]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:9199298]" /experiment="EXISTENCE:mutant phenotype:GO:0031335 regulation of sulfur amino acid metabolic process [PMID:9199298]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:22696683]" /experiment="EXISTENCE:physical interaction:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:9799240]" /note="Zinc-finger DNA-binding transcription factor; targets strong transcriptional activator Met4p to promoters of sulfur metabolic genes; involved in transcriptional regulation of the methionine biosynthetic genes; feedforward loop controlling expression of MET32 and the lack of such a loop for MET31 may account for the differential actions of Met31p and Met32p; MET31 has a paralog, MET32, that arose from the whole genome duplication" /db_xref="GeneID:856069" /db_xref="SGD:S000005959" ORIGIN 1 mklaqdmnvd eiflkqaaea iavissspth tdpiirellh rirqssplsa vipapenvlk 61 agepenmarg liripetqtk rtggnnhske gaqlyscakc qlkfsrssdl rrhekvhslv 121 lphicsncgk gfarkdalkr hsntltcqrn rkklsegsdv dvdelikdai kngtgll // LOCUS NP_015288 157 aa linear PLN 30-JUN-2025 DEFINITION Egd1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015288 VERSION NP_015288.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183851.1 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11393. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..157 /product="Egd1p" /calculated_mol_wt="16889" Region 9..125 /region_name="NAC_BTF3" /note="basal transcription factor BTF3; cd22055" /db_xref="CDD:409234" Site order(24..26,29..30) /site_type="other" /note="ribosome binding motif" /db_xref="CDD:409234" Site order(57..67,72,74,86..92,94,108..110) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:409234" CDS 1..157 /gene="EGD1" /locus_tag="YPL037C" /coded_by="NM_001183851.1:1..474" /experiment="EXISTENCE:direct assay:GO:0005854 nascent polypeptide-associated complex [PMID:10219998]" /experiment="EXISTENCE:genetic interaction:GO:0006613 cotranslational protein targeting to membrane [PMID:10518932]" /experiment="EXISTENCE:mutant phenotype:GO:0000423 mitophagy [PMID:38177147]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0051082 unfolded protein binding [PMID:9482879]" /note="Subunit beta1 of the nascent polypeptide-associated complex (NAC); involved in protein targeting to mitochondria; peripheral component of cytoplasmic ribosomes; regulates Atg32p phosphorylation to promote respiration-induced mitophagy; enhances DNA binding of the Gal4p; homolog of human BTF3b; EGD1 has a paralog, BTT1, that arose from the whole genome duplication" /db_xref="GeneID:856070" /db_xref="SGD:S000005958" ORIGIN 1 mpidqeklak lqklsannkv ggtrrklnkk agssagankd dtklqsqlak lhavtidnva 61 eanffkddgk vmhfnkvgvq vaaqhntsvf yglpqeknlq dlfpgiisql gpeaiqalsq 121 laaqmekhea kapadaekkd eaipelvegq tfdadve // LOCUS NP_015289 947 aa linear PLN 30-JUN-2025 DEFINITION H(+)-exporting P2-type ATPase PMA2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015289 VERSION NP_015289.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183850.1 REFERENCE 1 (residues 1 to 947) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 947) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 947) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 947) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 947) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 947) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 947) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11394. Method: conceptual translation. FEATURES Location/Qualifiers source 1..947 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..947 /product="H(+)-exporting P2-type ATPase PMA2" /EC_number="7.1.2.1" /calculated_mol_wt="102041" Region 116..903 /region_name="P-type_ATPase_H" /note="plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; cd02076" /db_xref="CDD:319771" Site order(407..409,451..452,480,485,487,503..504,540..541, 586..589,638,644,663,666) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:319771" Site order(723..724,728,730,759,832) /site_type="other" /note="proton binding site [ion binding]" /db_xref="CDD:319771" CDS 1..947 /gene="PMA2" /locus_tag="YPL036W" /coded_by="NM_001183850.1:1..2844" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836|PMID:8396147]" /experiment="EXISTENCE:direct assay:GO:0008553 P-type proton-exporting transporter activity [PMID:8396147]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:1902600 proton transmembrane transport [PMID:8396147]" /note="Plasma membrane H+-ATPase; isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential" /db_xref="GeneID:856071" /db_xref="SGD:S000005957" ORIGIN 1 mssteakqyk ekpskeylha sdgddpanns aassssssst stsasssaaa vprkaaaasa 61 addsdsdedi dqlidelqsn ygegdesgee evrtdgvhag qrvvpekdls tdpaygltsd 121 evarrrkkyg lnqmaeenes livkflmffv gpiqfvmeaa ailaaglsdw vdvgvicall 181 llnasvgfiq efqagsivde lkktlantat virdgqliei panevvpgei lqlesgtiap 241 adgrivtedc flqidqsait geslaaekhy gdevfssstv ktgeafmvvt atgdntfvgr 301 aaalvgqasg veghftevln gigiillvlv iatlllvwta cfyrtvgivs ilrytlgiti 361 igvpvglpav vtttmavgaa ylakkqaivq klsaieslag veilcsdktg tltknklslh 421 epytvegvsp ddlmltacla asrkkkglda idkaflksli eypkakdalt kykvlefhpf 481 dpvskkvtav vespegeriv cvkgaplfvl ktveedhpip edvhenyenk vaelasrgfr 541 algvarkrge ghweilgvmp cmdpprddta qtinearnlg lrikmltgda vgiaketcrq 601 lglgtniyna erlglggggd mpgseladfv enadgfaevf pqhkyrvvei lqnrgylvam 661 tgdgvndaps lkkadtgiav egatdaarsa adivflapgl saiidalkts rqifhrmysy 721 vvyrialslh leiflglwia ilnnsldinl ivfiaifadv atltiaydna pyapepvkwn 781 lprlwgmsii lgivlaigsw itlttmflpn ggiiqnfgam ngvmflqisl tenwlifvtr 841 aagpfwssip swqlagavfa vdiiatmftl fgwwsenwtd ivsvvrvwiw sigifcvlgg 901 fyyimstsqa fdrlmngksl kekkstrsve dfmaamqrvs tqhekss // LOCUS NP_015291 165 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPL034W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015291 VERSION NP_015291.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183848.1 REFERENCE 1 (residues 1 to 165) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 165) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 165) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 165) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 165) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11395. Method: conceptual translation. FEATURES Location/Qualifiers source 1..165 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..165 /product="uncharacterized protein" /calculated_mol_wt="18773" CDS 1..165 /locus_tag="YPL034W" /coded_by="NM_001183848.1:1..498" /note="hypothetical protein; YPL034W is not essential gene" /db_xref="GeneID:856072" /db_xref="SGD:S000005955" ORIGIN 1 mttrktvdsr llewqttckh pvinltpekv dklyhlklks esknissnrl lpislsslqk 61 kmeklfikdk shshkpslpd pkvptlrtyk dggffisgkg smklpdiesa ihkflwkkyg 121 kglvycygcd ptgkkrhtew fnvpvlelps vlrlidsycl ggesr // LOCUS NP_015292 281 aa linear PLN 30-JUN-2025 DEFINITION Srl4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015292 VERSION NP_015292.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183847.1 REFERENCE 1 (residues 1 to 281) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 281) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 281) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 281) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 281) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11396. Method: conceptual translation. FEATURES Location/Qualifiers source 1..281 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..281 /product="Srl4p" /calculated_mol_wt="31794" Region 28..>230 /region_name="Rossmann-fold NAD(P)(+)-binding proteins" /note="A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous...; cl21454" /db_xref="CDD:473865" Site order(33,35..36,39,56..57,110..111,114,178..180,193,197, 228..230) /site_type="other" /note="NAD(P) binding site [chemical binding]" /db_xref="CDD:187535" Site order(143,180,193,197) /site_type="active" /db_xref="CDD:187535" CDS 1..281 /gene="SRL4" /locus_tag="YPL033C" /coded_by="NM_001183847.1:1..846" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24390141]" /experiment="EXISTENCE:mutant phenotype:GO:0009200 deoxyribonucleoside triphosphate metabolic process [PMID:18337697]" /note="hypothetical protein; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p" /db_xref="GeneID:856074" /db_xref="SGD:S000005954" ORIGIN 1 mkktiykvlv sfyqyvglgk kfhpshdtvl iiggssnelg ielcetfied yhtkvinidt 61 idsingknar rseklytfis ckdfsdikcl eesmlylqnl eiiptvlinn mqegiestll 121 kedkflrlde eslnefekiv rynlqsvili tkfclsnifp kvqaeaqeka kgfyivniss 181 vltlkpcksg thfitskcgi nsfhdgitse lklkdsnlnv ktliaylpsf eseahwkrls 241 psiskhlvhc llegrygdti leskrsigdi llitgfkssf t // LOCUS NP_015293 825 aa linear PLN 30-JUN-2025 DEFINITION Svl3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015293 VERSION NP_015293.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183846.1 REFERENCE 1 (residues 1 to 825) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 825) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 825) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 825) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 825) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11397. Method: conceptual translation. FEATURES Location/Qualifiers source 1..825 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..825 /product="Svl3p" /calculated_mol_wt="92013" CDS 1..825 /gene="SVL3" /locus_tag="YPL032C" /coded_by="NM_001183846.1:1..2478" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:32491201|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:32491201|PMID:14562095|PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:9751732]" /note="hypothetical protein; mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; relocalizes from bud neck to cytoplasm upon DNA replication stress; SVL3 has a paralog, PAM1, that arose from the whole genome duplication" /db_xref="GeneID:856075" /db_xref="SGD:S000005953" ORIGIN 1 msssslrvla ignnpnilfy tsrfqlakni dlyhvndsks cqfeieteyy gkdrfelenh 61 ftsiehltea lssksseavf diiimsapsl qelsslaskl tsiidsntki flessgfiql 121 epfvklsmes phvnvfsilt dldirqigpn hfkhfpstak entiylgesk sstekyssgv 181 itllttfekl faklfsniki nlcnfssief lsqqwklais ricfdpllim feqenpsdld 241 qqiiakplis glvteiitva ktmgarlnss hdnensllsl wknsyhstnk ppalvyhfih 301 qttplnidil llqtilladd fgiktpylef lysvlsqfer lnsgkskwfi rsdektqilq 361 slqksqknes alqtqitslq gqisklrqel lmqakqheme tnelkekhqv alkaqaqaqa 421 qaqsqaqtsi ealtpteatn qsdtneykat gtpnlrdied malysvnygd spvrspppvv 481 ssqpqmnspl sshsqtfgen ngtndkllqe relqlrkkel elqerelefq kralqqqrfn 541 nsnnsiprkp sfpqlqqsan vrsnsrgmhg tngamsqpas agnfvdpiss siaaydpqqp 601 pslplqqpqq svqvqpfhsh sikptsrknr nsnmpnignp ssinmsdfgr ppnnssqtrl 661 nsmpthsivn qnrlrsqqsk nklnmphatn pnntfnqvpa pslnnhvptq rqfssstmie 721 vtnnnnkvnn sssnpdistn svvhnamqft ntnnntsstv dindpkniap ppttsvsaps 781 tptlssssqm anmaspstdn gdneeknggk kkrfglfkkk nkskk // LOCUS NP_015294 305 aa linear PLN 30-JUN-2025 DEFINITION cyclin-dependent serine/threonine-protein kinase PHO85 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015294 VERSION NP_015294.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183845.1 REFERENCE 1 (residues 1 to 305) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 305) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 305) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 305) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11398. Method: conceptual translation. FEATURES Location/Qualifiers source 1..305 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..305 /product="cyclin-dependent serine/threonine-protein kinase PHO85" /EC_number="2.7.11.22" /calculated_mol_wt="34775" Region 6..297 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(13..16,19,21,34,36,66,82..85,133,137..138,140, 150..151) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..305 /gene="PHO85" /locus_tag="YPL031C" /gene_synonym="LDB15" /coded_by="NM_001183845.1:1..918" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:7973731|PMID:38233717|PMID:19823668|PMID:12407105|PM ID:8108735|PMID:9584169|PMID:7973730]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9853758]" /experiment="EXISTENCE:direct assay:GO:0019216 regulation of lipid metabolic process [PMID:31678512]" /experiment="EXISTENCE:direct assay:GO:0032880 regulation of protein localization [PMID:8539622]" /experiment="EXISTENCE:direct assay:GO:0046822 regulation of nucleocytoplasmic transport [PMID:31422915]" /experiment="EXISTENCE:direct assay:GO:0055088 lipid homeostasis [PMID:31678512]" /experiment="EXISTENCE:direct assay:GO:0071073 positive regulation of phospholipid biosynthetic process [PMID:27743455]" /experiment="EXISTENCE:direct assay:GO:1901987 regulation of cell cycle phase transition [PMID:29146254]" /experiment="EXISTENCE:direct assay:GO:1990860 Pho85-Pho80 CDK-cyclin complex [PMID:8108735]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668|PMID:15738404]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:3915785]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668|PMID:15738404]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:16964260]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:12077337]" /experiment="EXISTENCE:genetic interaction:GO:0031647 regulation of protein stability [PMID:16611745]" /experiment="EXISTENCE:genetic interaction:GO:0032878 regulation of establishment or maintenance of cell polarity [PMID:17853895]" /experiment="EXISTENCE:genetic interaction:GO:0045936 negative regulation of phosphate metabolic process [PMID:3915785]" /experiment="EXISTENCE:genetic interaction:GO:0050849 negative regulation of calcium-mediated signaling [PMID:16455487]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:19823668]" /experiment="EXISTENCE:mutant phenotype:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:9593297|PMID:38233717]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:19823668]" /experiment="EXISTENCE:mutant phenotype:GO:0006974 DNA damage response [PMID:16964260]" /experiment="EXISTENCE:mutant phenotype:GO:0016239 positive regulation of macroautophagy [PMID:20417603]" /experiment="EXISTENCE:mutant phenotype:GO:0016242 negative regulation of macroautophagy [PMID:20417603]" /experiment="EXISTENCE:mutant phenotype:GO:0031647 regulation of protein stability [PMID:16508019]" /experiment="EXISTENCE:mutant phenotype:GO:0031648 protein destabilization [PMID:38233717]" /experiment="EXISTENCE:mutant phenotype:GO:0045719 negative regulation of glycogen biosynthetic process [PMID:9584169]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:9584169|PMID:16611745|PMID:7973730|PMID:8108735|PMID :7973731]" /note="Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels, environmental conditions and progression through the cell cycle; involved in the hyperphosphorylation of Srl3p (Whi7p), regulating protein stability, mRNA levels and promotion of START; human lissencephaly-associated homolog CDK5 functionally complements null mutation" /db_xref="GeneID:856076" /db_xref="SGD:S000005952" ORIGIN 1 mssssqfkql eklgngtyat vykglnkttg vyvalkevkl dseegtpsta ireislmkel 61 khenivrlyd vihtenkltl vfefmdndlk kymdsrtvgn tprglelnlv kyfqwqllqg 121 lafchenkil hrdlkpqnll inkrgqlklg dfglarafgi pvntfssevv tlwyrapdvl 181 mgsrtystsi diwscgcila emitgkplfp gtndeeqlkl ifdimgtpne slwpsvtklp 241 kynpniqqrp prdlrqvlqp htkepldgnl mdflhgllql npdmrlsakq alhhpwfaey 301 yhhas // LOCUS NP_015295 567 aa linear PLN 30-JUN-2025 DEFINITION tRNA (uracil) methyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015295 VERSION NP_015295.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183844.1 REFERENCE 1 (residues 1 to 567) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 567) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 567) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 567) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 567) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11399. Method: conceptual translation. FEATURES Location/Qualifiers source 1..567 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..567 /product="tRNA (uracil) methyltransferase" /EC_number="2.1.1.211" /calculated_mol_wt="64724" Region 257..370 /region_name="AdoMet_MTase" /note="Predicted AdoMet-dependent methyltransferase; pfam07757" /db_xref="CDD:462255" CDS 1..567 /gene="TRM44" /locus_tag="YPL030W" /coded_by="NM_001183844.1:1..1704" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0016300 tRNA (uridine) methyltransferase activity [PMID:18025252]" /experiment="EXISTENCE:direct assay:GO:0030488 tRNA methylation [PMID:18025252]" /experiment="EXISTENCE:mutant phenotype:GO:0002128 tRNA nucleoside ribose methylation [PMID:32053677]" /experiment="EXISTENCE:mutant phenotype:GO:0016300 tRNA (uridine) methyltransferase activity [PMID:18025252]" /experiment="EXISTENCE:mutant phenotype:GO:0030488 tRNA methylation [PMID:18025252]" /note="tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene" /db_xref="GeneID:856077" /db_xref="SGD:S000005951" ORIGIN 1 mtgdgsahis knnqnqhkdr fkfivndksi lgpqwlslyq tdgkvtfaks hfeqammnvi 61 repninstvi lradilkein haaeagsepk fdesvlkkfe idngnesgee dvkkiniedl 121 nirscetses lklspvhefv rriiprnfyk daiinqtcli lnskdpnfqe tslivytphi 181 nsekdcpfyi prtqsvgill hqsvlsvhyi pfpedktaft deservvrta yrllqtankh 241 skgvmqgyek rvnhdqvvnk vnfqntyivl kkkyskflve nwaestdpkk hvfediaiaa 301 flielwikvy gpdfrskmqf rdlgcgngal cyillsesik glgidarkrk swsiyppevq 361 sslkeqviip sillrphpal krqvphlehn grffpvkvth eviapatvvy ssedllkspq 421 vntaefppdt fiignhsdel tcwipllghp ymvipccshn fsgqrvrfnv rkrsprsnei 481 knqnnsksty sglvdhveyi ssrvgwkvek emlripstrn aaiigvenat lkhfptqavy 541 dmiwedggae gwiqntmsll krnprnh // LOCUS NP_015296 737 aa linear PLN 30-JUN-2025 DEFINITION ATP-dependent RNA helicase SUV3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015296 VERSION NP_015296.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183843.1 REFERENCE 1 (residues 1 to 737) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 737) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 737) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 737) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 737) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11400. Method: conceptual translation. FEATURES Location/Qualifiers source 1..737 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..737 /product="ATP-dependent RNA helicase SUV3" /EC_number="3.6.4.13" /calculated_mol_wt="84194" Region 232..378 /region_name="DEXQc_Suv3" /note="DEXQ-box helicase domain of Suv3; cd17913" /db_xref="CDD:350671" Site order(241..247,324) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350671" Region 382..519 /region_name="SF2_C_suv3" /note="C-terminal helicase domain of ATP-dependent RNA helicase; cd18805" /db_xref="CDD:350192" Site order(462,465,494,498,501..502) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350192" Region 666..710 /region_name="SUV3_C" /note="Mitochondrial degradasome RNA helicase subunit C terminal; pfam12513" /db_xref="CDD:463616" CDS 1..737 /gene="SUV3" /locus_tag="YPL029W" /gene_synonym="LPB2" /coded_by="NM_001183843.1:1..2214" /experiment="EXISTENCE:direct assay:GO:0003724 RNA helicase activity [PMID:12426313|PMID:17658549]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0008859 exoribonuclease II activity [PMID:17658549]" /experiment="EXISTENCE:direct assay:GO:0045025 mitochondrial degradosome [PMID:12426313]" /experiment="EXISTENCE:genetic interaction:GO:0000372 Group I intron splicing [PMID:20064926]" /experiment="EXISTENCE:mutant phenotype:GO:0000957 mitochondrial RNA catabolic process [PMID:12426313]" /experiment="EXISTENCE:mutant phenotype:GO:0006264 mitochondrial DNA replication [PMID:21911497]" /note="ATP-dependent RNA helicase; component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron; expression of a processed form of human homolog SUPV3L1 carrying an N-terminal deletion of 46 amino acids rescues yeast suv3 null mutant" /db_xref="GeneID:856078" /db_xref="SGD:S000005950" ORIGIN 1 malvkystvf fplrslrlfv sikkayyhse phsidlfhdk dwivkrpkfl nlpknehskl 61 difqfnfnks esnnvylqds sfkdnldkam qfiyndklss ldakqvpikn lawlklrdyi 121 yqqlkdpklq aktyvpsvse iihpsspgnl isllincnki snlvwksvlk yslsnnittl 181 dkfihvlqqt fdhvyeqeil pmmtntddtd gahnvditnp aewfpearki rrhiimhigp 241 tnsgktyral qklksvdrgy yagplrllar evydrfhaek ircnlltgee virdlddrgn 301 sagltsgtve mvpinqkfdv vvldeiqmms dgdrgwawtn allgvvskev hlcgeksvlp 361 lvksivkmtg dkltineyer lgklsveekp ikdgikglrk gdcvvafskk kildlklkie 421 kdtnlkvavi ygslppetrv qqaalfnnge ydimvasdai gmglnlsidr vvfttnmkyn 481 geelmemtss qikqiggrag rfksrsasgg vpqgfitsfe skvlksvrka ieapveylkt 541 avtwptdeic aqlmtqfppg tptsvllqti sdelekssdn lftlsdlksk lkviglfehm 601 edipffdklk lsnapvkdmp mvtkaftkfc etiakrhtrg llsyrlpfnl ldyncipnes 661 yslevyesly niitlyfwls nrypnyfidm esakdlkyfc emiifekldr lkknpyahkp 721 fgstrghlss srrrlrt // LOCUS NP_015297 398 aa linear PLN 30-JUN-2025 DEFINITION acetyl-CoA C-acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015297 VERSION NP_015297.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183842.1 REFERENCE 1 (residues 1 to 398) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 398) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 398) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 398) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 398) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11401. Method: conceptual translation. FEATURES Location/Qualifiers source 1..398 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..398 /product="acetyl-CoA C-acetyltransferase" /EC_number="2.3.1.9" /calculated_mol_wt="41598" Region 4..396 /region_name="PLN02644" /note="acetyl-CoA C-acetyltransferase" /db_xref="CDD:215347" CDS 1..398 /gene="ERG10" /locus_tag="YPL028W" /gene_synonym="LPB3; TSM0115" /coded_by="NM_001183842.1:1..1197" /experiment="EXISTENCE:direct assay:GO:0003985 acetyl-CoA C-acetyltransferase activity [PMID:5571829|PMID:7989303]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:5571830]" /experiment="EXISTENCE:direct assay:GO:0006696 ergosterol biosynthetic process [PMID:5571829]" /experiment="EXISTENCE:mutant phenotype:GO:0006696 ergosterol biosynthetic process [PMID:200835]" /note="Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase); cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis; human ACAT1 functionally complements the growth defect caused by repression of ERG10 expression" /db_xref="GeneID:856079" /db_xref="SGD:S000005949" ORIGIN 1 msqnvyivst artpigsfqg slssktavel gavalkgala kvpeldaskd fdeiifgnvl 61 sanlgqapar qvalaaglsn hivastvnkv casamkaiil gaqsikcgna dvvvaggces 121 mtnapyympa aragakfgqt vlvdgverdg lndaydglam gvhaekcard wditreqqdn 181 faiesyqksq ksqkegkfdn eivpvtikgf rgkpdtqvtk deeparlhve klrsartvfq 241 kengtvtaan aspindgaaa vilvsekvlk eknlkplaii kgwgeaahqp adftwapsla 301 vpkalkhagi edinsvdyfe fneafsvvgl vntkilkldp skvnvyggav alghplgcsg 361 arvvvtllsi lqqeggkigv aaicngggga ssivieki // LOCUS NP_015298 245 aa linear PLN 30-JUN-2025 DEFINITION Sma1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015298 VERSION NP_015298.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183841.1 REFERENCE 1 (residues 1 to 245) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 245) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 245) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 245) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11402. Method: conceptual translation. FEATURES Location/Qualifiers source 1..245 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..245 /product="Sma1p" /calculated_mol_wt="28268" CDS 1..245 /gene="SMA1" /locus_tag="YPL027W" /coded_by="NM_001183841.1:1..738" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141|PMID:16148007]" /experiment="EXISTENCE:mutant phenotype:GO:0032120 ascospore-type prospore membrane formation [PMID:16148007|PMID:11470404]" /note="hypothetical protein involved in prospore membrane assembly; involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p" /db_xref="GeneID:856080" /db_xref="SGD:S000005948" ORIGIN 1 mactndgpnk ypeivsvkhl fqhsgskhef sagkrfsksi gkifkrnsal ktsrtetanh 61 kmelkkregv tllppvpesl lhklnswlet fsstknmkie enkivineke irdsvsyypd 121 knggsavfcy lpdlvlyykp pikvtgkqcp ikrspwesme iqyqkfmypl erlerqfeev 181 pfrpwyfamr lkelyrccer sftnaanrgk arllrgkqrt kksyhktvnl vsakisthsn 241 apspg // LOCUS NP_015299 502 aa linear PLN 30-JUN-2025 DEFINITION putative serine/threonine protein kinase SKS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015299 VERSION NP_015299.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183840.1 REFERENCE 1 (residues 1 to 502) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 502) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 502) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 502) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 502) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11403. Method: conceptual translation. FEATURES Location/Qualifiers source 1..502 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..502 /product="putative serine/threonine protein kinase SKS1" /EC_number="2.7.11.1" /calculated_mol_wt="57713" Region 9..331 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(16..19,22,24,37,39,123,139..142,186,190..191,193, 203..204) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270895" CDS 1..502 /gene="SKS1" /locus_tag="YPL026C" /gene_synonym="SHA3" /coded_by="NM_001183840.1:1..1509" /experiment="EXISTENCE:direct assay:GO:0004672 protein kinase activity [PMID:16319894]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:18417610]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0010827 regulation of D-glucose transmembrane transport [PMID:8948096]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:8948096]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:24603354]" /note="Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway; SKS1 has a paralog, VHS1, that arose from the whole genome duplication" /db_xref="GeneID:856081" /db_xref="SGD:S000005947" ORIGIN 1 mlsdcllnnf ritaqigsga yglvfhvvdi ltsreyavkt vfksssmdef ynknglnnns 61 qvarttllqt qlyhffksfq kklflpsvdl dsilqltene lnrlphyrei afqlrvqshg 121 nivkihqvle ssiatfivmd yydrdlftsi vddkhfvnhg ilikkvflql csaldhchrl 181 giyhcdikpe nvlldrndna ylcdfglstk skylapnvcv gssyymaper ilyclntttn 241 gihvdeccss lptdtgdiws lgiilinltc irnpwlkahq kedntfqhfa ndnnvlkkil 301 pisdelftvl tkilqlnpyt ridmktlmse vssltsftre gplsqvpils sevymthiir 361 nenlflsdls hfsadqeqqq qqqqqqqqvq eqeqeqkqeq iqnqeqaqqq qeeedaepes 421 dipstynsdg smekyeytnn hnnstfltss mdstpyqsdi ddvsaskdck fqqdtlrnrl 481 lclqmnfstl tdgpnekwlp dy // LOCUS NP_015301 241 aa linear PLN 30-JUN-2025 DEFINITION Rmi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015301 VERSION NP_015301.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183838.1 REFERENCE 1 (residues 1 to 241) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 241) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 241) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 241) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 241) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11404. Method: conceptual translation. FEATURES Location/Qualifiers source 1..241 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..241 /product="Rmi1p" /calculated_mol_wt="26729" Region <49..215 /region_name="RMI1_N" /note="RecQ mediated genome instability protein; pfam08585" /db_xref="CDD:462527" CDS 1..241 /gene="RMI1" /locus_tag="YPL024W" /gene_synonym="NCE4" /coded_by="NM_001183838.1:1..726" /experiment="EXISTENCE:direct assay:GO:0000400 four-way junction DNA binding [PMID:15899853]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:15899853]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006265 DNA topological change [PMID:22885009]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:17693398]" /experiment="EXISTENCE:direct assay:GO:0031422 RecQ family helicase-topoisomerase III complex [PMID:15899853]" /experiment="EXISTENCE:direct assay:GO:0043388 positive regulation of DNA binding [PMID:17693398]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:23036200]" /experiment="EXISTENCE:genetic interaction:GO:0006974 DNA damage response [PMID:15889139]" /experiment="EXISTENCE:physical interaction:GO:0031422 RecQ family helicase-topoisomerase III complex [PMID:15889139]" /note="Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing, DNA catenation/decatenation and ssDNA binding activities of Top3p; involved in response to DNA damage; functions in S phase-mediated cohesion establishment via a pathway involving the Ctf18-RFC complex and Mrc1p; stimulates Top3p DNA catenation/decatenation activity; null mutants display increased rates of recombination and delayed S phase" /db_xref="GeneID:856083" /db_xref="SGD:S000005945" ORIGIN 1 msfssilsqd itdditppay satlgsreqi vfrayqnepw lagtasnlil dkklvivdre 61 llfqvlmven itkskltqid diktkldpkk qkvdrlrsga qgngakkyev itqvdmeddg 121 nvadnncake nnsnnnssaa knkavfkltl qsksgdvffa instpiswss cmlgskivil 181 pgtvfnrgvf ilkdsqvifl gginrvwnen rdqkfcdyle sklqrdkqlv nggskkrkan 241 d // LOCUS NP_015302 657 aa linear PLN 30-JUN-2025 DEFINITION methylenetetrahydrofolate reductase (NAD(P)H) MET12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015302 VERSION NP_015302.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183837.1 REFERENCE 1 (residues 1 to 657) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 657) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 657) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 657) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11405. Method: conceptual translation. FEATURES Location/Qualifiers source 1..657 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..657 /product="methylenetetrahydrofolate reductase (NAD(P)H) MET12" /EC_number="1.5.1.20" /calculated_mol_wt="73811" Region 16..643 /region_name="MTHFR" /note="Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; cl00246" /db_xref="CDD:444783" Site order(50,78,107..109,129..130,150,152,156,158,171,174, 177..178,187,189,286) /site_type="other" /note="FAD binding site [chemical binding]" /db_xref="CDD:238299" CDS 1..657 /gene="MET12" /locus_tag="YPL023C" /coded_by="NM_001183837.1:1..1974" /experiment="EXISTENCE:direct assay:GO:0004489 methylenetetrahydrofolate reductase [NAD(P)H] activity [PMID:10600168]" /experiment="EXISTENCE:direct assay:GO:0035999 tetrahydrofolate interconversion [PMID:10600168]" /note="Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR)" /db_xref="GeneID:856084" /db_xref="SGD:S000005944" ORIGIN 1 msirdlyhar aspfisleff ppktelgtrn lmermhrmta ldplfitvtw gaggttaekt 61 ltlaslaqqt lnipvcmhlt ctntekaiid daldrcynag irnilalrgd ppigedwlds 121 qsnespfkya vdlvryikqs ygdkfcvgva aypeghcege aegheqdplk dlvylkekve 181 agadfvitql fydvekfltf emlfrerisq dlplfpglmp insyllfhra aklshasipp 241 ailsrfppei qsddnavksi gvdilieliq eiyqrtsgri kgfhfytlnl ekaiaqivsq 301 spvlshivne sseeegedet sgeigsienv piedadgdiv lddsneetva nrkrrrhssl 361 dsaklifnra ivtekglryn nengsmpskk alisiskghg tlgrdatwde fpngrfgdsr 421 spaygeidgy gpsikvsksk alelwgipkt igdlkdifik ylegstdaip wsdlglsaet 481 aliqeeliql nyrgyltlas qpatnatlss dkifgwgpak grlyqkafve mfihrqqwet 541 tlkpkldhyg rrkfsyyagd ssgsfetnld phsssvvtwg vfpnspvkqt tiieeesfka 601 wrdeafsiws ewaklfprnt panillrlvh kdyclvsivh hdfketdelw emlldqa // LOCUS NP_015303 1100 aa linear PLN 30-JUN-2025 DEFINITION ssDNA endodeoxyribonuclease RAD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015303 VERSION NP_015303.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183836.1 REFERENCE 1 (residues 1 to 1100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1100) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11406. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1100 /product="ssDNA endodeoxyribonuclease RAD1" /calculated_mol_wt="126240" Region 203..1066 /region_name="rad1" /note="DNA repair protein (rad1); TIGR00596" /db_xref="CDD:273163" CDS 1..1100 /gene="RAD1" /locus_tag="YPL022W" /gene_synonym="LPB9; RAD12" /coded_by="NM_001183836.1:1..3303" /experiment="EXISTENCE:direct assay:GO:0000014 single-stranded DNA endodeoxyribonuclease activity [PMID:8253764]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:8253764]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9852079]" /experiment="EXISTENCE:direct assay:GO:0006289 nucleotide-excision repair [PMID:7559571]" /experiment="EXISTENCE:mutant phenotype:GO:0000710 meiotic mismatch repair [PMID:11514439]" /experiment="EXISTENCE:mutant phenotype:GO:0000735 removal of nonhomologous ends [PMID:1411547|PMID:7891718]" /experiment="EXISTENCE:mutant phenotype:GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends [PMID:1411547|PMID:7891718]" /experiment="EXISTENCE:mutant phenotype:GO:0006277 DNA amplification [PMID:23271978]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:3065620]" /experiment="EXISTENCE:physical interaction:GO:0000110 nucleotide-excision repair factor 1 complex [PMID:8621533]" /note="Single-stranded DNA endonuclease (with Rad10p); cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein" /db_xref="GeneID:856085" /db_xref="SGD:S000005943" ORIGIN 1 msqlfyqgds ddelqeeltr qttqasqssk iknedepdds nhlnevened skvldddavl 61 yplipnepdd ietskpnind irpvdiqltl plpfqqkvve nslitedali imgkglglld 121 ivanllhvla tptsingqlk ralvlvlnak pidnvrikea leelswfsnt gkddddtave 181 sddelferpf nvvtadslsi ekrrklyisg gilsitsril ivdllsgivh pnrvtgmlvl 241 nadslrhnsn esfileiyrs kntwgfikaf seapetfvme fsplrtkmke lrlknvllwp 301 rfrvevsscl natnktshnk vievkvsltn smsqiqfglm eclkkciael srknpelald 361 wwnmenvldi nfirsidsvm vpnwhrisye skqlvkdirf lrhllkmlvt sdavdffgei 421 qlsldankps vsrkysespw llvdeaqlvi syakkrifyk neytleenpk weqlihilhd 481 ishermtnhl qgptlvacsd nltclelakv lnasnkkrgv rqvllnklkw yrkqreetkk 541 lvkevqsqdt fpenatlnvs stfskeqvtt krrrtrgasq vaaveklrna gtnvdmevvf 601 edhklseeik kgsgddlddg qeenaandsk ifeiqeqene iliddgdaef dngeleyvgd 661 lpqhitthfn kdlwaehcne yeyvdrqdei listfkslnd ncslqemmps yiimfepdis 721 firqievyka ivkdlqpkvy fmyygesiee qshltaikre kdaftklire nanlshhfet 781 nedlshyknl aerklklskl rksntrnagg qqgfhnltqd vvivdtrefn aslpgllyry 841 girvipcmlt vgdyvitpdi clerksisdl igslqnnrla nqckkmlkyy ayptlliefd 901 egqsfslepf serrnyknkd istvhpissk lsqdeiqlkl aklvlrfptl kiiwsssplq 961 tvniilelkl greqpdpsna vilgtnkvrs dfnstakglk dgdneskfkr llnvpgvski 1021 dyfnlrkkik sfnklqklsw neinelinde dltdriyyfl rtekeeqeqe stdenlespg 1081 kttddnalhd hhndvpeapv // LOCUS NP_015304 187 aa linear PLN 30-JUN-2025 DEFINITION Ecm23p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015304 VERSION NP_015304.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183835.1 REFERENCE 1 (residues 1 to 187) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 187) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 187) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 187) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 187) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11407. Method: conceptual translation. FEATURES Location/Qualifiers source 1..187 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..187 /product="Ecm23p" /calculated_mol_wt="20483" Region 127..178 /region_name="ZnF_GATA" /note="zinc finger binding to DNA consensus sequence [AT]GATA[AG]; smart00401" /db_xref="CDD:214648" CDS 1..187 /gene="ECM23" /locus_tag="YPL021W" /gene_synonym="SRD2" /coded_by="NM_001183835.1:1..564" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /experiment="EXISTENCE:mutant phenotype:GO:0007124 pseudohyphal growth [PMID:11889490]" /note="Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p" /db_xref="GeneID:856086" /db_xref="SGD:S000005942" ORIGIN 1 mlynkeqgts gasssgrrtk fhfdrfvqmv lfiaanpnyc csvasipksg vtpdlkradi 61 leqkikslns alspklkees rlggplhnps ilpapsfssl pissngkksl agyrpksrkk 121 qtilpngqpk ecatcgdtwt sqwrsgpngn velcsrcgia yrkkmekkir sqqssddgtk 181 nfifknk // LOCUS NP_015305 621 aa linear PLN 30-JUN-2025 DEFINITION SUMO protease ULP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015305 VERSION NP_015305.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183834.1 REFERENCE 1 (residues 1 to 621) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 621) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 621) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 621) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 621) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 621) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 621) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11408. Method: conceptual translation. FEATURES Location/Qualifiers source 1..621 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..621 /product="SUMO protease ULP1" /EC_number="3.4.22.68" /calculated_mol_wt="72247" Region <243..>389 /region_name="PRK03918" /note="DNA double-strand break repair ATPase Rad50" /db_xref="CDD:235175" Region 447..615 /region_name="Peptidase_C48" /note="Ulp1 protease family, C-terminal catalytic domain; pfam02902" /db_xref="CDD:397169" CDS 1..621 /gene="ULP1" /locus_tag="YPL020C" /gene_synonym="NIB1" /coded_by="NM_001183834.1:1..1866" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:20647537|PMID:10713161]" /experiment="EXISTENCE:direct assay:GO:0005643 nuclear pore [PMID:12471376]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:20647537]" /experiment="EXISTENCE:direct assay:GO:0008234 cysteine-type peptidase activity [PMID:10094048]" /experiment="EXISTENCE:direct assay:GO:0016926 protein desumoylation [PMID:10094048]" /experiment="EXISTENCE:direct assay:GO:0016929 deSUMOylase activity [PMID:10094048]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:10094048]" /experiment="EXISTENCE:mutant phenotype:GO:0016926 protein desumoylation [PMID:10094048]" /experiment="EXISTENCE:mutant phenotype:GO:0016929 deSUMOylase activity [PMID:10094048]" /note="Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; contributes to regulation of telomeric silencing; localizes to the nuclear pore channel; sequestered to the nucleolus under stress conditions" /db_xref="GeneID:856087" /db_xref="SGD:S000005941" ORIGIN 1 msvevdkhrn tlqyhkknpy splfspisty rcyprvlnnp sesrrsasfs giykkrtnts 61 rfnylndrrv lsmeesmkdg sdraskagfi ggiretlwns gkylwhtfvk neprnfdgse 121 veasgnsdve srssgsrssd vpyglrenys sdtrkhkfdt stwalpnkrr riesegvgtp 181 stspisslas qksncdsdns itfsrdpfgw nkwktsaigs nsenntsdqk nsydrrqygt 241 afirkkkvak qninntklvs raqseevtyl rqifngeykv pkilkeerer qlklmdmdke 301 kdtglkksii dltekiktil iennknrlqt rnendddlvf vkekkissle rkhkdylnqk 361 lkfdrsilef ekdfkrynei lnerkkiqed lkkkkeqlak kklvpelnek dddqvqkala 421 srentqlmnr dnieitvrdf ktlaprrwln dtiieffmky iekstpntva fnsffytnls 481 ergyqgvrrw mkrkktqidk ldkiftpinl nqshwalgii dlkkktigyv dslsngpnam 541 sfailtdlqk yvmeeskhti gedfdlihld cpqqpngydc giyvcmntly gsadapldfd 601 ykdairmrrf iahliltdal k // LOCUS NP_015306 835 aa linear PLN 30-JUN-2025 DEFINITION vacuolar transporter chaperone [Saccharomyces cerevisiae S288C]. ACCESSION NP_015306 VERSION NP_015306.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183833.1 REFERENCE 1 (residues 1 to 835) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 835) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 835) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 835) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 835) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11409. Method: conceptual translation. FEATURES Location/Qualifiers source 1..835 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..835 /product="vacuolar transporter chaperone" /calculated_mol_wt="96423" Region 2..133 /region_name="SPX_VTC2_like" /note="SPX domain of the vacuolar transport chaperone Vtc2 and similar proteins; cd14480" /db_xref="CDD:269901" Region 199..553 /region_name="PolyPPase_VTC2-3_like" /note="Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, and -3, and similar proteins; cd07892" /db_xref="CDD:143630" Site order(205,207,209) /site_type="active" /note="signature motif [active]" /db_xref="CDD:143630" Site order(206,314,317,511,515) /site_type="other" /note="putative dimer interface [polypeptide binding]" /db_xref="CDD:143630" Site order(209,300,312,315,323,325,341,343,354,356,422,424,436, 493,495,525..528) /site_type="active" /note="polyP binding site [active]" /db_xref="CDD:143630" Site order(209,300,323,325,341,356,422,424,440,493,495,525..528) /site_type="active" /db_xref="CDD:143630" Site order(209,300,323,325,341,356,422,424,440,493,525..527) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:143630" Site order(300,323,341,526..528) /site_type="active" /note="acceptor-phosphate pocket [active]" /db_xref="CDD:143630" Site order(493,495) /site_type="other" /note="putative metal binding residues [ion binding]" /db_xref="CDD:143630" Region 673..803 /region_name="VTC1" /note="Vacuolar transporter chaperone [Posttranslational modification, protein turnover, chaperones]; COG5264" /db_xref="CDD:227589" CDS 1..835 /gene="VTC3" /locus_tag="YPL019C" /gene_synonym="PHM2" /coded_by="NM_001183833.1:1..2508" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:11823419|PMID:11102525]" /experiment="EXISTENCE:direct assay:GO:0005516 calmodulin binding [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:direct assay:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:genetic interaction:GO:0006797 polyphosphate metabolic process [PMID:11102525]" /experiment="EXISTENCE:mutant phenotype:GO:0006797 polyphosphate metabolic process [PMID:11102525]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:17079729]" /experiment="EXISTENCE:mutant phenotype:GO:0016237 microautophagy [PMID:17079729]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:11823419]" /experiment="EXISTENCE:physical interaction:GO:0033254 vacuolar transporter chaperone complex [PMID:11823419]" /note="Regulatory subunit of vacuolar transporter chaperone (VTC) complex; involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; important regulator of substrate invagination from the vacuolar membrane; targeted to vacuole via AP-3 pathway; VTC3 has a paralog, VTC2, that arose from the whole genome duplication" /db_xref="GeneID:856088" /db_xref="SGD:S000005940" ORIGIN 1 mlfgikland vyppwkdsyi dyerlkkllk esvihdgrss vdswsernes dfvealdkel 61 ekvytfqisk ynavlrkldd leentksaek iqkinseqfk ntleecldea qrldnfdrln 121 ftgfikivkk hdklhpnyps vksllqvrlk elpfnnseey spllyrisyl yeflrsnydh 181 pntvskslas tsklshfsnl edasfksykf wvhddnimev karilrhlpa lvyasvpnen 241 ddfvdnlesd vrvqpearln igsksnslss dgnsnqdvei gksksvifpq sydptittly 301 fdndffdlyn nrllkisgap tlrlrwigkl ldkpdiflek rtftentetg nssfeeirlq 361 mkakfinnfi fkndpsykny linqlrergt qkeeleklsr dfdniqnfiv eeklqpvlra 421 tynrtafqip gdqsirvtid snimyireds ldknrpirnp enwhrddids nipnplrflr 481 ageyskfpys vmeikvinqd nsqmpnyewi kdltnshlvn evpkfslylq gvaslfgedd 541 kyvnilpfwl pdletdirkn pqeayeeekk tlqkqksihd kldnmrrlsk isvpdgktte 601 rqgqkdqntr hviadledhe ssdeegtalp kksavkkgkk fktnaaflki lagkniseng 661 ndpysddtds assfqlppgv kkpvhllkna gpvkveakvw lanertfnrw lsvttllsvl 721 tfsiynsvqk aefpqladll ayvyffltlf cgvwayrtyl krltlikgrs gkhldapvgp 781 ilvavvlivt lvvnfsvafk eaarrerglv nvssqpslpr tlkpiqdfif nlvge // LOCUS NP_015307 369 aa linear PLN 30-JUN-2025 DEFINITION Ctf19p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015307 VERSION NP_015307.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183832.1 REFERENCE 1 (residues 1 to 369) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 369) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 369) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 369) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 369) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11410. Method: conceptual translation. FEATURES Location/Qualifiers source 1..369 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..369 /product="Ctf19p" /calculated_mol_wt="42651" Region 149..248 /region_name="DRWD-N_ScCTF19" /note="N-terminal double-RWD domain of Saccharomyces cerevisiae chromosome transmission fidelity 19 (CTF19) and related proteins; cd23838" /db_xref="CDD:467670" Site order(149..154,156..158,160..161,165,169,182,201,210..212, 225..226,236..239,242) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467670" Region 260..364 /region_name="DRWD-C_ScCTF19" /note="C-terminal double-RWD domain of Saccharomyces cerevisiae chromosome transmission fidelity 19 (CTF19) and related proteins; cd23839" /db_xref="CDD:467671" Site order(267,272,279,284,297,299,310..314,317,333..334, 339..340,342..343,345..350,363..364) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:467671" CDS 1..369 /gene="CTF19" /locus_tag="YPL018W" /gene_synonym="MCM18" /coded_by="NM_001183832.1:1..1110" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:10189365]" /experiment="EXISTENCE:direct assay:GO:0000817 COMA complex [PMID:14633972]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10189365]" /experiment="EXISTENCE:direct assay:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:10189365]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:10189365]" /experiment="EXISTENCE:mutant phenotype:GO:0007094 mitotic spindle assembly checkpoint signaling [PMID:22426531]" /experiment="EXISTENCE:mutant phenotype:GO:0008608 attachment of spindle microtubules to kinetochore [PMID:10189365]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /experiment="EXISTENCE:mutant phenotype:GO:0071459 protein localization to chromosome, centromeric region [PMID:26653857]" /note="Outer kinetochore protein, needed for accurate chromosome segregation; component of kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as platform for kinetochore assembly; required for spindle assembly checkpoint; minimizes potentially deleterious centromere-proximal crossovers by preventing meiotic DNA break formation proximal to centromere; homolog of human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2" /db_xref="GeneID:856089" /db_xref="SGD:S000005939" ORIGIN 1 mdftsdttns hdtsnshlsl edavgthhag eadvnidgde kqqlsllddd qvralklqee 61 kdalltrrnt llqeiqtyqn ilmkennskt kngdilqndi tqdflnlisi sssnpnsais 121 drkrvering ltnlqkelvt kydtlpllnm nlrlsylrdh typhlqvsvq srdrvhndgi 181 evlvvnykfc rntmnpfeiq fkmfykfeds tllkweilri stnvrlkakq llatrnfqkc 241 llslyefdki kskktgifqn linllkrktr cylmnnsdsl iverviregr lttiklqinf 301 iitmpgergk prncflpmsk isialwkgge rfnqidldei cyglikeygv ktglkeicnv 361 clfpdmyar // LOCUS NP_015308 499 aa linear PLN 30-JUN-2025 DEFINITION Irc15p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015308 VERSION NP_015308.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183831.1 REFERENCE 1 (residues 1 to 499) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 499) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 499) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 499) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 499) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11411. Method: conceptual translation. FEATURES Location/Qualifiers source 1..499 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..499 /product="Irc15p" /calculated_mol_wt="54025" Region 18..487 /region_name="Lpd" /note="Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; COG1249" /db_xref="CDD:440861" CDS 1..499 /gene="IRC15" /locus_tag="YPL017C" /coded_by="NM_001183831.1:1..1500" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:19285398]" /experiment="EXISTENCE:direct assay:GO:0007020 microtubule nucleation [PMID:19285398]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:19285398]" /experiment="EXISTENCE:direct assay:GO:0016651 oxidoreductase activity, acting on NAD(P)H [PMID:30267443]" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /experiment="EXISTENCE:mutant phenotype:GO:0034453 microtubule anchoring [PMID:19285398]" /experiment="EXISTENCE:mutant phenotype:GO:0045144 meiotic sister chromatid segregation [PMID:18069899]" /experiment="EXISTENCE:mutant phenotype:GO:0045931 positive regulation of mitotic cell cycle [PMID:19285398]" /experiment="EXISTENCE:mutant phenotype:GO:0051315 attachment of mitotic spindle microtubules to kinetochore [PMID:19285398]" /note="Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci; IRC15 has a paralog, LPD1, that arose from the whole genome duplication" /db_xref="GeneID:856090" /db_xref="SGD:S000005938" ORIGIN 1 mggedeilst medfaavydv lvigcgpggf taamqasqag lltacvdqra slggaylvdg 61 avpsktllye sylyrllqqq elieqrgtrl fpakfdmqaa qsalkhniee lgnvykrels 121 knnvtvykgt aafkdphhve iaqrgmkpfi veakyivvat gsaviqcpgv aidndkiiss 181 dkalsldyip srftimgggt igleiacifn nlgsrvtive sqseicqnmd nelasatktl 241 lqcqgiafll dtrvqlaead aagqlnitll nkvskktyvh hcdvlmvsig rrpllkgldi 301 ssiglderdf venvdvqtqs llkyphikpi gdvtlgpmla lkaeeqaira iqsigctgsd 361 gtsncgfppn vlycqpqigw vgyteeglak aripyqkgrv lfsqnvrynt llpreenttv 421 spfikvlids rdmkilgvhm inddanells qasmavslgl tahdvckvpf phpslsesfk 481 qavqlamang tspgvhvre // LOCUS NP_015309 1314 aa linear PLN 30-JUN-2025 DEFINITION Swi1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015309 VERSION NP_015309.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183830.2 REFERENCE 1 (residues 1 to 1314) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1314) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1314) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1314) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1314) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11412. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1314 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1314 /product="Swi1p" /calculated_mol_wt="147808" Region 407..490 /region_name="ARID_Swi1p-like" /note="ARID/BRIGHT DNA binding domain of yeast SWI/SNF chromatin-remodeling complex subunit Swi1p and similar proteins; cd16871" /db_xref="CDD:350635" Site order(429..435,460,462..463,466,474..476,478) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:350635" Region 618..>654 /region_name="PKK" /note="Polo kinase kinase; pfam12474" /db_xref="CDD:463600" CDS 1..1314 /gene="SWI1" /locus_tag="YPL016W" /gene_synonym="ADR6; GAM3; LPA1" /coded_by="NM_001183830.2:1..3945" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:3143101]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:8016655]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:8016655|PMID:18644858|PMID:8159677|PMID:8127913]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:10198436]" /experiment="EXISTENCE:mutant phenotype:GO:0016514 SWI/SNF complex [PMID:8159677]" /experiment="EXISTENCE:mutant phenotype:GO:0031496 positive regulation of mating type switching [PMID:6436497]" /experiment="EXISTENCE:mutant phenotype:GO:0034198 cellular response to amino acid starvation [PMID:10549298]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:10549298|PMID:3542227|PMID:8016655|PMID:1339306]" /experiment="EXISTENCE:mutant phenotype:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14580348]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:14580348|PMID:11865042]" /note="Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; self-assembles to form [SWI+] prion and to alter expression pattern; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer" /db_xref="GeneID:856091" /db_xref="SGD:S000005937" ORIGIN 1 mdffnlnnnn nnnntttttt ttnnnntnnn ntnnnnnpan ntnnnnstgh ssntnnntnn 61 nntntgasgv ddfqnffdpk pfdqnldsnn nnsnsnnndn nnsntvasst nftsptavvn 121 naapanvtgg kaanfiqnqs pqfnspydsn nsntnlnsls pqailaknsi idssnlplqa 181 qqqlyggnnn nnstgiandn vitphfitnv qsisqnssss tpntnsnstp nanqqflpfn 241 nsasnngnlt snqlisnyaa snsmdrsssa snefvpntsd nnnnsnnhnm rnnsnnktsn 301 nnnvtavpaa tpantnnsts nantvfsera amfaalqqkq qqrfqalqqq qqqqqnqqqq 361 nqqpqqqqqq qqnpkflqsq rqqqqrsilq slnpalqeki stelnnkqye lfmkslienc 421 kkrnmplqsi peignrkinl fylymlvqkf ggadqvtrtq qwsmvaqrlq isdyqqlesi 481 yfrillpyer hmisqegike tqakriflqq flqellkkvq qqqqaaalan annninsass 541 aptpaapgas vpataapgte agivpvsant pkslnsnini nvnnnnigqq qvkkprkqrv 601 kkktkkelel erkeredfqk rqqklledqq rqqkllletk lrqqyeielk klpkvykrsi 661 vrnykplinr lkhyngydin yiskigekid snkpiflfap elgainlhal smslqsknlg 721 eintalntll vtsadsnlki slvkypelld slailgmnll snlsqnvvpy hrntsdyyye 781 dagsnqyyvt qhdkmvdkif ekvnnnatlt pndsndekvt ilvdsltgnq lptptpteme 841 pdldtecfis mqstspavkq wdllpepirf lpnqfplkih rtpyltslkk ikdeiddpft 901 kintrgaedp kvlindqlst ismilrnisf sdnnsrimsr nfylkrfisd llwlvlihpe 961 nftcnrkiln fkkdlvivls nishlleias sidcllilil visfgqpkln pmassssfgs 1021 esltfnefql qwgkyqtfgv dilaklfsle kpnlnyfksi llnkntgnnl ydrnsnnnhk 1081 dkkllrrlln lyndnnknnn nrhnllndvv sflfsaiplq qvlsqsadps llidqfspvi 1141 sqsltsilvi vqkilplsne vfeisennsd snsnnngnkd ssfnfnknlp fvwlsseeni 1201 gsgllklsei ilninnstsk ntllqqqnys kvllpsinis cvqlikclve ksicfencln 1261 ndpeilkkia sipnlfptdl eifqlftnps vdiqiinqyq llynlkndil tnle // LOCUS NP_015310 357 aa linear PLN 30-JUN-2025 DEFINITION histone deacetylase HST2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015310 VERSION NP_015310.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183829.1 REFERENCE 1 (residues 1 to 357) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 357) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 357) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 357) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 357) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11413. Method: conceptual translation. FEATURES Location/Qualifiers source 1..357 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..357 /product="histone deacetylase HST2" /EC_number="2.3.1.286" /calculated_mol_wt="39848" Region 26..277 /region_name="SIRT1" /note="Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins...; cd01408" /db_xref="CDD:238699" Site order(34,36..37,44..45,97,115..116,118,135,223,228, 249..250,269) /site_type="other" /note="NAD+ binding site [chemical binding]" /db_xref="CDD:238699" Site order(117,135,182,184..188,227..229) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238699" Site order(143,146,170,173) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:238699" CDS 1..357 /gene="HST2" /locus_tag="YPL015C" /coded_by="NM_001183829.1:1..1074" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:17110954]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11226170]" /experiment="EXISTENCE:direct assay:GO:0017136 histone deacetylase activity, NAD-dependent [PMID:10811920]" /experiment="EXISTENCE:genetic interaction:GO:0045950 negative regulation of mitotic recombination [PMID:16051752]" /experiment="EXISTENCE:mutant phenotype:GO:0000183 rDNA heterochromatin formation [PMID:16051752|PMID:11226170]" /experiment="EXISTENCE:mutant phenotype:GO:0017136 histone deacetylase activity, NAD-dependent [PMID:10841563]" /experiment="EXISTENCE:mutant phenotype:GO:0045950 negative regulation of mitotic recombination [PMID:16051752]" /note="Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export" /db_xref="GeneID:856092" /db_xref="SGD:S000005936" ORIGIN 1 msvstastem svrkiaahmk snpnakvifm vgagistscg ipdfrspgtg lyhnlarlkl 61 pypeavfdvd ffqsdplpfy tlakelypgn frpskfhyll klfqdkdvlk rvytqnidtl 121 erqagvkddl iieahgsfah chcigcgkvy ppqvfkskla ehpikdfvkc dvcgelvkpa 181 ivffgedlpd sfsetwlnds ewlrekitts gkhpqqplvi vvgtslavyp faslpeeipr 241 kvkrvlcnle tvgdfkankr ptdlivhqys defaeqlvee lgwqedfeki ltaqggmgdn 301 skeqlleivh dlenlsldqs ehesadkkdk klqrlnghds dedgasnsss sqkaake // LOCUS NP_015311 381 aa linear PLN 30-JUN-2025 DEFINITION Cip1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015311 VERSION NP_015311.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183828.1 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11414. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..381 /product="Cip1p" /calculated_mol_wt="42346" CDS 1..381 /gene="CIP1" /locus_tag="YPL014W" /coded_by="NM_001183828.1:1..1146" /experiment="EXISTENCE:direct assay:GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity [PMID:27005485]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:27005485]" /experiment="EXISTENCE:genetic interaction:GO:0001933 negative regulation of protein phosphorylation [PMID:27005485]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:27005485]" /experiment="EXISTENCE:mutant phenotype:GO:0001933 negative regulation of protein phosphorylation [PMID:27005485]" /note="Cyclin-dependent kinase inhibitor; activated by environmental stress; interacts with and inhibits the Cdc28p/Cln2p, G1/S phase cyclin-dependent kinase complex but not S-phase, or M-phase complexes; overexpression blocks cells in G1 phase and stabilizes the Cdc28p inhibitor Sic1p, while disruption accelerates the G1/S phase transition; phosphorylated during S phase in a Cdc28p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus" /db_xref="GeneID:856093" /db_xref="SGD:S000005935" ORIGIN 1 mllerlhkrl hagssrrsqe nkdknckped alpiqpeaqh qtqdpqplln cdyddmiafd 61 rnlstpvftp vmtpinnsss nqakssdasy fppylnanrt rqnsasslas svsdfaqnfk 121 qhtfynnnaq ftsftpqfvg lllevyqntc sdptitpfdt tnppsgilnr vakaaiqqse 181 lqqldigcdr nswlltlvrq rllqevrkdg ylsrntslts lppppppqfs emlrvpspfv 241 naditdpipl sntnsnpnvs sttsltntln wyslqrsnvs mknrngssqy iselqpqpil 301 artnsnnsvs nsnafslltp tpttdsafnf niallsrqrs niissplast rlptanvste 361 essilpnesl klkrdllrlk r // LOCUS NP_015312 121 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein bS16m MRPS16 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015312 VERSION NP_015312.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183827.1 REFERENCE 1 (residues 1 to 121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 121) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11415. Method: conceptual translation. FEATURES Location/Qualifiers source 1..121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..121 /product="mitochondrial 37S ribosomal protein bS16m MRPS16" /calculated_mol_wt="13508" Region 6..96 /region_name="S16" /note="ribosomal protein S16; TIGR00002" /db_xref="CDD:272848" CDS 1..121 /gene="MRPS16" /locus_tag="YPL013C" /gene_synonym="bS16m" /coded_by="NM_001183827.1:1..366" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:12392552]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:856094" /db_xref="SGD:S000005934" ORIGIN 1 mtcglvrirl arfgrknspv ynivvansrk ardakpievl gtyvpvpspv tkrelkrgvv 61 pikdvkldfd rtkywigvga qpsetvtkll rkagilndaw atsknsnvnr kvvfermetl 121 e // LOCUS NP_015313 1228 aa linear PLN 30-JUN-2025 DEFINITION mRNA-binding protein RRP12 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015313 VERSION NP_015313.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183826.1 REFERENCE 1 (residues 1 to 1228) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1228) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1228) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1228) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1228) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11416. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1228 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1228 /product="mRNA-binding protein RRP12" /calculated_mol_wt="137378" Region 414..615 /region_name="NUC173" /note="NUC173 domain; pfam08161" /db_xref="CDD:462386" CDS 1..1228 /gene="RRP12" /locus_tag="YPL012W" /coded_by="NM_001183826.1:1..3687" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14729571]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /note="Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats" /db_xref="GeneID:856095" /db_xref="SGD:S000005933" ORIGIN 1 mdqdkvafll eledklakir sqvnsklenq khiaiiltav eeniagqatn dvsknivnyi 61 isfmslldqa vdpstheikd iqlassstyl ldlifhyspk vllrskfsei ltkiapcita 121 ekanaplira aigcleslli aqdaqawnnt ydlnvtpkrg lqgilelsld vrpkvrkral 181 davhavllnp pvaptaehva avfvadfcdk qlagilndls nlsnkqlkaq ktkedinasv 241 mrslrlitsv vstgqwpssq ieplcdvllg vtksseqylv sasfecfesm fktmaettis 301 sglaenkylr vldtifalkp snvdtlltks wiavvikgms tyathqplka lrkipgvfhi 361 mctylasetp evyqaasqcl isilsesvkd dlllytpsvd ekvfknvdei isqiaktfid 421 flsiryshcs reilkilvaa fnkfryrsnp hflkslkivd twrvneeqfm dlrneielvi 481 gasisamgpe milaeaplnl dnpsserpgr awllplirdy tknanlatfq nelapyiksf 541 qskfdkvpee siqlrvfqti vdqiwstlpr fcelpmdlre sftdefasel ssllysevel 601 rttichalkv laesnvsyae essshnvlll qrfpiseaqk nieylstkst nllavlfnvy 661 tqttpnarsy iletidqylk itskedlekt fnnvcgllkn smneessgnv nkekkkpqlt 721 atlldliicm itylpvssys alfsmfsltv nsadaliqkr ayriitklse lksgstavaq 781 fisdienvmv dsassvqtsa kaarltaikt ivellpldhl dfivrtvaev ilstkdvnek 841 sretafdtli cmgrkmnepn giiklfqipg ydpttpdqss siseffkiis agligesqhm 901 vsssitgyac lvfefkneld sgilmdiydt ielyltsnsr eivksaigft kvcvlglpee 961 lmrpkvpell lkllrwsheh tghfkakvkh iierlirrfg ydyieanfpe edrrlltnir 1021 kmrnrnkrkd eevttgvsdv aatkgsrfms afdeavygsd eendngsdqe envaggkmkn 1081 gakqfivesg dnpldlldsq tlahisstrp kkfnknqnra rfnddafnfd segklvvkgq 1141 pkpstnvddp lsavtsgina yleavksgpv rgqrnklkfr kngkdsdefg ddddgekdsr 1201 lmrgrvnqgn kigkhnkkgp kfksrkkl // LOCUS NP_015314 353 aa linear PLN 30-JUN-2025 DEFINITION Taf3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015314 VERSION NP_015314.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183825.1 REFERENCE 1 (residues 1 to 353) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 353) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 353) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 353) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 353) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11417. Method: conceptual translation. FEATURES Location/Qualifiers source 1..353 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..353 /product="Taf3p" /calculated_mol_wt="40165" Region 5..83 /region_name="BTP" /note="Bromodomain transcription factors and PHD domain containing proteins; smart00576" /db_xref="CDD:128846" CDS 1..353 /gene="TAF3" /locus_tag="YPL011C" /gene_synonym="TAF47" /coded_by="NM_001183825.1:1..1062" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:17660549]" /experiment="EXISTENCE:direct assay:GO:0005669 transcription factor TFIID complex [PMID:10788514|PMID:15448131]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:15448131|PMID:12138208]" /note="TFIID subunit (47 kDa); involved in promoter binding and RNA polymerase II transcription initiation" /db_xref="GeneID:856096" /db_xref="SGD:S000005932" ORIGIN 1 mttnndfyfa llrisilqll kaqgfdrarp slvdvmtdly akflsllase vssiaqarcd 61 qddtialqdi tlalenlgiv kptnvldvyd enselsssrg mekfkdwciy stqltdarit 121 alptvellqs eekesdplsa ipdylnqllq nkgakqklet knrktelied linnnglddw 181 iklviarqri nmieraskke sqnvpalphi agykssilsr hhhttitned rmpsamtprd 241 edalteiqen pfvtsklpim rkenrlenit lsfedeeles lgevegpnqk sqennneesf 301 kennksltes phgddrdism fqfdsnvdtk waeqedmdst fqrrtsldyg gyf // LOCUS NP_015315 189 aa linear PLN 30-JUN-2025 DEFINITION coatomer subunit zeta [Saccharomyces cerevisiae S288C]. ACCESSION NP_015315 VERSION NP_015315.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183824.1 REFERENCE 1 (residues 1 to 189) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 189) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 189) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 189) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 189) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11418. Method: conceptual translation. FEATURES Location/Qualifiers source 1..189 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..189 /product="coatomer subunit zeta" /calculated_mol_wt="21557" Region 3..189 /region_name="RET3" /note="Vesicle coat complex COPI, zeta subunit [Posttranslational modification, protein turnover, chaperones]; COG5541" /db_xref="CDD:227828" CDS 1..189 /gene="RET3" /locus_tag="YPL010W" /coded_by="NM_001183824.1:1..570" /experiment="EXISTENCE:direct assay:GO:0030126 COPI vesicle coat [PMID:21435344]" /experiment="EXISTENCE:mutant phenotype:GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum [PMID:8617224]" /experiment="EXISTENCE:mutant phenotype:GO:0030126 COPI vesicle coat [PMID:8617224]" /note="Zeta subunit of the coatomer complex (COPI); COPI coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER" /db_xref="GeneID:856097" /db_xref="SGD:S000005931" ORIGIN 1 msslslytvq avlildqqge riyakyyqpp hrsdeghqll fnsvkkqkef ekqlyrkthk 61 qdseilifed hlvlykeyid itiylvasle eneivlqqgf sairgaldli lnsgmdkkni 121 qenydmvlla idetidngvi letdsntias rvskpptnep qmaldldkgf lgawgfaksk 181 fqerlqqgl // LOCUS NP_015316 1038 aa linear PLN 30-JUN-2025 DEFINITION Rqc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015316 VERSION NP_015316.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183823.1 REFERENCE 1 (residues 1 to 1038) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1038) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1038) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1038) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1038) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1038) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1038) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11419. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1038 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1038 /product="Rqc2p" /calculated_mol_wt="118939" Region 14..680 /region_name="RqcH" /note="Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones]; COG1293" /db_xref="CDD:440904" Region 576..685 /region_name="NFACT-R_1" /note="NFACT protein RNA binding domain; pfam05670" /db_xref="CDD:428576" Region 915..1017 /region_name="NFACT-C" /note="NFACT protein C-terminal domain; pfam11923" /db_xref="CDD:432191" CDS 1..1038 /gene="RQC2" /locus_tag="YPL009C" /gene_synonym="TAE2" /coded_by="NM_001183823.1:1..3117" /experiment="EXISTENCE:direct assay:GO:0000049 tRNA binding [PMID:25554787]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:23222640|PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0022626 cytosolic ribosome [PMID:31133701|PMID:25554787]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:25554787]" /experiment="EXISTENCE:direct assay:GO:0072344 rescue of stalled ribosome [PMID:25554787|PMID:27385828|PMID:27129255|PMID:31189955]" /experiment="EXISTENCE:direct assay:GO:0140708 CAT tailing [PMID:31133701]" /experiment="EXISTENCE:direct assay:GO:1904678 alpha-aminoacyl-tRNA binding [PMID:31133701]" /experiment="EXISTENCE:direct assay:GO:1990112 RQC complex [PMID:23178123]" /experiment="EXISTENCE:direct assay:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:27129255|PMID:27385828]" /experiment="EXISTENCE:genetic interaction:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23479637]" /experiment="EXISTENCE:mutant phenotype:GO:0043043 peptide biosynthetic process [PMID:25554787]" /experiment="EXISTENCE:mutant phenotype:GO:0072344 rescue of stalled ribosome [PMID:26943317]" /experiment="EXISTENCE:mutant phenotype:GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process [PMID:23479637]" /experiment="EXISTENCE:physical interaction:GO:1990112 RQC complex [PMID:23479637]" /note="Component of the Ribosome Quality Control (RQC) complex; RQC is a ribosome-bound complex required for degradation of polypeptides arising from stalled translation; recruits ala- and thr-charged tRNA to the A site and directs CAT (carboxyl-terminal alanine and threonine) tailing, the noncanonical elongation of nascent chains independent of mRNA or 40S subunits, promoting LTN1-mediated ubiquitination and peptide release from stalled ribosomes; monitors translation stress and signals this to Hsf1p" /db_xref="GeneID:856098" /db_xref="SGD:S000005930" ORIGIN 1 mkqrisaldl lllarelkqd legyrlsniy niadsskqfl lkfnkpdskl nvvvdcglri 61 yltefsrpip ptpsgfvvkl rkhlkakrlt alkqvdqdri lvlqfadghf ylvleffsag 121 nvilldenrr imalqrvvle henkvgqiye mfdeslfttn nesadesiek nrkaeytsel 181 vnewikavqa kyesditvik qlniqgkega kkkkvkvpsi hklllskvph lssdllsknl 241 kvfnidpses clnlleetds laellnstql eynqlltttd rkgyilakrn enyisekdta 301 dlefiydtfh pfkpyinggd tdssciieve gpynrtldkf fstiesskya lriqnqesqa 361 qkkiddarae ndrkiqalld vqelnerkgh liienaplie evklavqgli dqqmdwntie 421 klikseqkkg nriaqllnlp lnlkqnkisv kldlsskeln tssdednese gnttdsssds 481 dsedmesske rstksmkrks nekinvtidl glsayanate yfnikktsaq kqkkveknvg 541 kamknievki dqqlkkklkd shsvlkkirt pyffekyswf issegflvmm gkspaetdqi 601 yskyiedddi ymsnsfnshv wiknpektev ppntlmqagi lcmssseaws kkissspwwc 661 faknvskfdg sdnsilpega frlknendqn hlppaqlvmg fgflwkvkts gnedngddde 721 eeeeeeeeee eeeeeeeeee eeekeeeeke eeqqqdedds nevnglekgg dsndstknns 781 fehdnlekdi ekhctissdt dsdsgnakak ndnsstqril depgvpisli eninsnvrgk 841 rgklkkiqkk yadqdeterl lrlealgtlk giekqqqrkk eeimkrevre drknkrekqr 901 rlqalkftkk ekarvnydkh kselkpsldk gdvvddiipv fapwpallky kykvkiqpgs 961 akktktltei lhyfksrpld gsstdnemdw pqehemikgl keqdlvlllc vdklkvtiag 1021 qkstknggns skkgkkkr // LOCUS NP_015317 861 aa linear PLN 30-JUN-2025 DEFINITION DNA helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015317 VERSION NP_015317.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183822.1 REFERENCE 1 (residues 1 to 861) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 861) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 861) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 861) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11420. Method: conceptual translation. FEATURES Location/Qualifiers source 1..861 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..861 /product="DNA helicase" /EC_number="5.6.2.3" /calculated_mol_wt="98675" Region <4..>55 /region_name="Cas3" /note="CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; COG1203" /db_xref="CDD:440816" Region 36..>60 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Site 44..50 /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:350670" Region 136..849 /region_name="rad3" /note="DNA repair helicase (rad3); TIGR00604" /db_xref="CDD:273169" CDS 1..861 /gene="CHL1" /locus_tag="YPL008W" /gene_synonym="CTF1; LPA9; MCM12" /coded_by="NM_001183822.1:1..2586" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714|PMID:17483413|PMID:15020404]" /experiment="EXISTENCE:genetic interaction:GO:0036297 interstrand cross-link repair [PMID:22912599]" /experiment="EXISTENCE:mutant phenotype:GO:0000785 chromatin [PMID:24086532]" /experiment="EXISTENCE:mutant phenotype:GO:0003678 DNA helicase activity [PMID:10931920]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:15020404|PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0031571 mitotic G1 DNA damage checkpoint signaling [PMID:34493312]" /experiment="EXISTENCE:mutant phenotype:GO:0034085 establishment of sister chromatid cohesion [PMID:23334284]" /experiment="EXISTENCE:physical interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:15020404]" /note="Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome" /db_xref="GeneID:856099" /db_xref="SGD:S000005929" ORIGIN 1 mdkkeysetf yhpykpydiq vqlmetvyrv lsegkkiail esptgtgktl slicatmtwl 61 rmnkadiftr metniktned dsenlsddep dwvidtyrks vlqekvdlln dyekhlnein 121 ttsckqlktm cdldkehgry ksvdplrkkr kgarhldvsl eeqdfiprpy esdsenndts 181 kstrggrisd kdyklselns qiitlldkid gkvsrdpnng drfdvtnqnp vkiyyasrty 241 sqlgqftsql rlpsfpssfr dkvpdekvky lplaskkqlc inpkvmkwkt leaindacad 301 lrhskegcif yqntnewrhc pdtlalrdmi fseiqdiedl vplgkslgic pyyasrealp 361 iaevvtlpyq yllsestrss lqinlensiv iideahnlie tinsiyssqi sledlknchk 421 givtyfnkfk srlnpgnrvn llklnsllmt liqfivknfk kigqeidpnd mftgsnidtl 481 nihkllryik vskiaykidt ynqalkeees sknenpiket hkksvssqpl lfkvsqflyc 541 ltnltsegqf ffeknysiky mllepskpfe silnqakcvv laggtmepms eflsnllpev 601 psedittlsc nhvipkenlq tyitnqpele ftfekrmsps lvnnhlfqff vdlskavpkk 661 ggivaffpsy qylahviqcw kqndrfatln nvrkifyeak dgddilsgys dsvaegrgsl 721 llaivggkls eginfqddlc ravvmvglpf pnifsgeliv krkhlaakim ksggteeeas 781 ratkefmeni cmkavnqsvg rairhandya niylldvryn rpnfrkklsr wvqdsinseh 841 tthqvisstr kffsmrslns r // LOCUS NP_015318 588 aa linear PLN 30-JUN-2025 DEFINITION transcription factor TFIIIC subunit TFC8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015318 VERSION NP_015318.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183821.1 REFERENCE 1 (residues 1 to 588) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 588) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 588) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 588) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 588) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11421. Method: conceptual translation. FEATURES Location/Qualifiers source 1..588 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..588 /product="transcription factor TFIIIC subunit TFC8" /calculated_mol_wt="67553" Region 88..122 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 132..177 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 185..204 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 515..585 /region_name="zf-TFIIIC" /note="Putative zinc-finger of transcription factor IIIC complex; pfam12660" /db_xref="CDD:372246" CDS 1..588 /gene="TFC8" /locus_tag="YPL007C" /coded_by="NM_001183821.1:1..1767" /experiment="EXISTENCE:direct assay:GO:0000127 transcription factor TFIIIC complex [PMID:10567530|PMID:2002052|PMID:1474578]" /experiment="EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2404611|PMID:2649882]" /experiment="EXISTENCE:direct assay:GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding [PMID:2404611]" /experiment="EXISTENCE:direct assay:GO:0006383 transcription by RNA polymerase III [PMID:2183033|PMID:3633923|PMID:8464480]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:2002052]" /experiment="EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2183033]" /experiment="EXISTENCE:genetic interaction:GO:0006383 transcription by RNA polymerase III [PMID:10567530]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:10567530]" /note="Subunit of RNA polymerase III transcription initiation factor complex; one of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90" /db_xref="GeneID:856100" /db_xref="SGD:S000005928" ORIGIN 1 mkllkdllvd rkefedwknn ltwardgtly lttfpdisig qpkyakdinc nsknlfhvke 61 fplefenkld felaqqngll nsqpvcyprv ckpspiddwm avlsnngnvs vfkdnkmltn 121 ldskgnlssr tyhcfewnpi essivvgned gelqffsirk nsentpefyf essirlsdag 181 skdwvthivw yedvlvaals nnsvfsmtvs asshqpvsrm iqnasrrkit dlkivdykvv 241 ltcpgyvhki dlknysissl ktgslenfhi iplnhekest illmsnktsy kvlledelhv 301 tadniiapyl ekkfkkwsti wnefnnyett lvihgislsp dgysiaivyd mervafkyki 361 aseqsfnimf aplyhtwtis eravglawyq tyqiynqslp klpenfsmnk kllngnypis 421 ldfqsylnal mkseemriim flnmtidkps ilsflealye yainkkselt nsfdlacvls 481 iaailkreap iyngtllmkn sfleetfnle sftadpetvt sttnntwkrc gvtllpiltt 541 hvkicpvskq rvidikrddl ndygwftrgl lerfneisvy cgttlevm // LOCUS NP_015319 1170 aa linear PLN 30-JUN-2025 DEFINITION sphingolipid transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_015319 VERSION NP_015319.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183820.1 REFERENCE 1 (residues 1 to 1170) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1170) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1170) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1170) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1170) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11422. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1170 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1170 /product="sphingolipid transporter" /calculated_mol_wt="132515" Region 23..1140 /region_name="2A060601" /note="Niemann-Pick C type protein family; TIGR00917" /db_xref="CDD:273337" CDS 1..1170 /gene="NCR1" /locus_tag="YPL006W" /coded_by="NM_001183820.1:1..3513" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:14562095|PMID:16138904]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0015918 sterol transport [PMID:31543266]" /experiment="EXISTENCE:direct assay:GO:0032934 sterol binding [PMID:31543266]" /experiment="EXISTENCE:mutant phenotype:GO:0006665 sphingolipid metabolic process [PMID:14970192]" /note="Vacuolar membrane protein involved in sterol trafficking with Npc2p; conformational changes drive sterol translocation across the glycocalyx and into the vacuolar membrane; involved in sphingolipid metabolism; cells lacking Ncr1p exhibit high levels of long chain bases (LCBs), similar to accumulation of lipids observed in patients with Neimann-Pick C disease due to loss-of-function mutations in human NPC1; transits through the vacuolar protein sorting pathway via the AP-3 pathway" /db_xref="GeneID:856101" /db_xref="SGD:S000005927" ORIGIN 1 mnvlwiialv gqlmrlvqgt atcamygncg kksvfgnelp cpvprsfepp vlsdetskll 61 vevcgeewke vryacctkdq vvalrdnlqk aqplisscpa clknfnnlfc hftcaadqgr 121 fvnitkveks kedkdivael dvfmnsswas efydscknik fsatngyamd ligggaknys 181 qflkflgdak pmlggspfqi nykydlanee kewqefndev yacddaqykc acsdcqescp 241 hlkplkdgvc kvgplpcfsl svlifytica lfafmwyylc krkkngamiv dddivpesgs 301 ldesetnvfe sfnnetnffn gklanlftkv gqfsvenpyk ilittvfsif vfsfiifqya 361 tletdpinlw vsknsekfke keyfddnfgp fyrteqifvv netgpvlsye tlhwwfdven 421 fiteelqsse nigyqdlcfr ptedstcvie sftqyfqgal pnkdswkrel qecgkfpvnc 481 lptfqqplkt nllfsdddil nahafvvtll ltnhtqsanr weerleeyll dlkvpeglri 541 sfnteislek elnnnndist vaisylmmfl yatwalrrkd gktrlllgis gllivlasiv 601 caagfltlfg lkstliiaev ipflilaigi dniflithey drnceqkpey sidqkiisai 661 grmspsilms llcqtgcfli aafvtmpavh nfaiystvsv ifngvlqlta yvsilslyek 721 rsnykqitgn eetkesflkt fyfkmltqkr liiiifsawf ftslvflpei qfgldqtlav 781 pqdsylvdyf kdvysflnvg ppvymvvknl dltkrqnqqk icgkfttcer dslanvleqe 841 rhrstitepl anwlddyfmf lnpqndqccr lkkgtdevcp psfpsrrcet cfqqgswnyn 901 msgfpegkdf meylsiwina psdpcplggr apystalvyn etsvsasvfr tahhplrsqk 961 dfiqaysdgv risssfpeld mfayspfyif fvqyqtlgpl tlkligsaii liffissvfl 1021 qnirssflla lvvtmiivdi galmallgis lnavslvnli icvglgvefc vhivrsftvv 1081 psetkkdans rvlyslntig esvikgitlt kfigvcvlaf aqskifdvfy frmwftliiv 1141 aalhallflp allslfgges yrddsieaed // LOCUS NP_015320 606 aa linear PLN 30-JUN-2025 DEFINITION Aep3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015320 VERSION NP_015320.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183819.1 REFERENCE 1 (residues 1 to 606) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 606) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 606) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 606) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11423. Method: conceptual translation. FEATURES Location/Qualifiers source 1..606 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..606 /product="Aep3p" /calculated_mol_wt="70179" Region 223..250 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 256..292 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 367..392 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" Region 397..446 /region_name="PPR_2" /note="PPR repeat family; pfam13041" /db_xref="CDD:463778" Region 398..428 /region_name="PPR repeat" /note="PPR repeat [structural motif]" /db_xref="CDD:276811" CDS 1..606 /gene="AEP3" /locus_tag="YPL005W" /coded_by="NM_001183819.1:1..1821" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0070124 mitochondrial translational initiation [PMID:19843529]" /experiment="EXISTENCE:mutant phenotype:GO:0016071 mRNA metabolic process [PMID:14742425]" /note="Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA" /db_xref="GeneID:856102" /db_xref="SGD:S000005926" ORIGIN 1 mntlrcltqa lsksgreapk lyqkvifpgl fregipianv kkvdekiids ptstsvngea 61 kkivrhgvky ereqvkeyls slptltlsrk qirddydeer akrmymfskq tnssnkfqkl 121 ltaksqeftr elltllidct sneknsgper ftrkflkfsn deipplpdfs knpqlfenyi 181 gilshtkfnf rsssklngiv rkmlrhllhp tnkttlplrs aqvyndsiyf fsehfdfasc 241 reifaqmkae gtkpntitfn lllrnvvkns hirktkhpdd evlfylrsmr nhgvfadvit 301 wttcynflrd evsrqlyivq mgehlgnfnv nfvytvlrng dyraedclkv laanslpisr 361 ktfylcierl lneeqletas klldygfqhl ksnfkldsea mnhfmrvfan kgrsdlaflc 421 yntcrkiyki kpdsqtfeml fkalvrngnt knfgavlqyi kdlkvsegfg lrtsywrtka 481 dsifkfgspn tlseksieka rkllgnlias egefswkiwk esdssqkkil rflgcipttl 541 rctntaqdhq kptnlpsnis qkkreyrnrv kaiatkaale krmayikdnd vafkkelvkr 601 rivgev // LOCUS NP_015321 341 aa linear PLN 30-JUN-2025 DEFINITION lipid-binding protein LSP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015321 VERSION NP_015321.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183818.1 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11424. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..341 /product="lipid-binding protein LSP1" /calculated_mol_wt="37940" Region 1..264 /region_name="Pil1" /note="Eisosome component PIL1; pfam13805" /db_xref="CDD:404658" CDS 1..341 /gene="LSP1" /locus_tag="YPL004C" /coded_by="NM_001183818.1:1..1026" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:22123866]" /experiment="EXISTENCE:direct assay:GO:0032126 eisosome [PMID:16496001]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006897 endocytosis [PMID:16496001]" /experiment="EXISTENCE:mutant phenotype:GO:0009408 response to heat [PMID:15016821]" /experiment="EXISTENCE:mutant phenotype:GO:0061024 membrane organization [PMID:38096056]" /experiment="EXISTENCE:mutant phenotype:GO:0070941 eisosome assembly [PMID:36601791]" /note="Stress-responsive eisosome organizer and core component; eisosomes are large immobile patch structures at the cell cortex associated with endocytosis; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family" /db_xref="GeneID:856103" /db_xref="SGD:S000005925" ORIGIN 1 mhrtyslrnq raptaaelqa pppppsstks kffgkasias sfrknaagnf gpelarklsq 61 lvktekgvlr amevvaserr eaakqlslwg adndddvsdv tdklgvliye lgelqdqfid 121 kydqyrvtlk sirnieasvq psrdrkekit deiahlkykd pqstkipvle qelvraeaes 181 lvaeaqlsni treklkaays ymfdslrels ekfaliagyg kallelldds pvtpgearpa 241 ydgyeasrqi imdaesales wtldmaavkp tlsfhqtvdd vyededgeee eepeiqngdi 301 pgqvveeeev ewttevpvdd eaheadhhvs qnghtsgsen i // LOCUS NP_015322 462 aa linear PLN 30-JUN-2025 DEFINITION Ula1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015322 VERSION NP_015322.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183817.1 REFERENCE 1 (residues 1 to 462) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 462) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 462) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 462) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 462) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11425. Method: conceptual translation. FEATURES Location/Qualifiers source 1..462 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..462 /product="Ula1p" /calculated_mol_wt="52722" Region 2..460 /region_name="E1_enzyme_family" /note="Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; cl22428" /db_xref="CDD:451392" Site order(33,115,136..137,143) /site_type="other" /note="substrate interface [chemical binding]" /db_xref="CDD:238760" CDS 1..462 /gene="ULA1" /locus_tag="YPL003W" /gene_synonym="ENR2" /coded_by="NM_001183817.1:1..1389" /experiment="EXISTENCE:direct assay:GO:0019781 NEDD8 activating enzyme activity [PMID:9545234]" /experiment="EXISTENCE:direct assay:GO:0045116 protein neddylation [PMID:9545234]" /experiment="EXISTENCE:mutant phenotype:GO:0019781 NEDD8 activating enzyme activity [PMID:9531531]" /experiment="EXISTENCE:mutant phenotype:GO:0045116 protein neddylation [PMID:9545234]" /note="Protein that activates Rub1p (NEDD8) before neddylation; acts together with Uba3p; may play a role in protein degradation" /db_xref="GeneID:856104" /db_xref="SGD:S000005924" ORIGIN 1 merydrqlrl wgalgqdsln rsrvcvvgpa tpllqevfkn lvlagisslt wlkvecavqs 61 gslflaelkk dleplaskql eyeendlrkt lqqpqydwtr fsvviltcig eqtamldlne 121 irrqrgtkfp pvlntfvsgf ygyiylvlse thfvlqahpd skkydlrlqn pwpelinyvd 181 tfdlskmdta tfsgipytvl lmkciakler dgnngritid qmkkvldqic lplgndviye 241 pnyveakrya ylacsqndcc keledllrnl eisdygndwh dtynyeiltl lltlkniake 301 ngelsfqplt gtlpdmestt enyirlkkly evkakldksr veeslarskk ivsqdvletf 361 cshygevrki lppksdllgi fstsnallda lvmvqfweqp avtaedkdef iglrvddnys 421 vmaffggavv qeaiklithh yvpidnlfly nginnssaty ki // LOCUS NP_015323 233 aa linear PLN 30-JUN-2025 DEFINITION ESCRT-II subunit protein SNF8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015323 VERSION NP_015323.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183816.1 REFERENCE 1 (residues 1 to 233) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 233) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 233) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 233) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 233) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11426. Method: conceptual translation. FEATURES Location/Qualifiers source 1..233 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..233 /product="ESCRT-II subunit protein SNF8" /calculated_mol_wt="26823" Region 4..214 /region_name="EAP30" /note="EAP30/Vps36 family; pfam04157" /db_xref="CDD:461201" CDS 1..233 /gene="SNF8" /locus_tag="YPL002C" /gene_synonym="VPL14; VPS22" /coded_by="NM_001183816.1:1..702" /experiment="EXISTENCE:direct assay:GO:0000814 ESCRT II complex [PMID:12194858]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:7785322]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12194858]" /experiment="EXISTENCE:mutant phenotype:GO:1904669 ATP export [PMID:26585826]" /note="Component of the ESCRT-II complex; ESCRT-II is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression" /db_xref="GeneID:856105" /db_xref="SGD:S000005923" ORIGIN 1 mkqfglaafd elkdgkyndv nktilekqsv elrdqlmvfq erlvefakkh nselqaspef 61 rskfmhmcss igidplslfd rdkhlftvnd fyyevclkvi eicrqtkdmn ggvisfqele 121 kvhfrklnvg lddleksidm lkslecfeif qirgkkflrs vpneltsdqt kileicsilg 181 yssisllkan lgweavrsks aldemvangl lwidyqggae alywdpswit rql // LOCUS NP_015324 374 aa linear PLN 30-JUN-2025 DEFINITION histone acetyltransferase catalytic subunit HAT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015324 VERSION NP_015324.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001183815.1 REFERENCE 1 (residues 1 to 374) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 374) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 374) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 374) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 374) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11427. Method: conceptual translation. FEATURES Location/Qualifiers source 1..374 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..374 /product="histone acetyltransferase catalytic subunit HAT1" /EC_number="2.3.1.48" /calculated_mol_wt="43742" Region 11..162 /region_name="Hat1_N" /note="Histone acetyl transferase HAT1 N-terminus; pfam10394" /db_xref="CDD:463071" Region 166..260 /region_name="N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate" /note="NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members...; cl17182" /db_xref="CDD:473072" Site order(220..222,232..233) /site_type="other" /note="Coenzyme A binding pocket [chemical binding]" /db_xref="CDD:173926" CDS 1..374 /gene="HAT1" /locus_tag="YPL001W" /gene_synonym="KAT1" /coded_by="NM_001183815.1:1..1125" /experiment="EXISTENCE:direct assay:GO:0000123 histone acetyltransferase complex [PMID:9575221|PMID:8858151]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16612003]" /experiment="EXISTENCE:direct assay:GO:0004402 histone acetyltransferase activity [PMID:7559580|PMID:8858151]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9575221|PMID:14761951]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:9575221|PMID:8858151]" /experiment="EXISTENCE:direct assay:GO:0006302 double-strand break repair [PMID:16612003]" /experiment="EXISTENCE:genetic interaction:GO:0031509 subtelomeric heterochromatin formation [PMID:15099519|PMID:10982821]" /experiment="EXISTENCE:mutant phenotype:GO:0004402 histone acetyltransferase activity [PMID:8858151|PMID:7559580|PMID:9575221]" /experiment="EXISTENCE:physical interaction:GO:0000123 histone acetyltransferase complex [PMID:8858151]" /note="Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex; uses the cofactor acetyl coenzyme A to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair" /db_xref="GeneID:856106" /db_xref="SGD:S000005922" ORIGIN 1 msandfkpet wtssanealr vsivgenavq fsplftypiy gdsekiygyk dliihlafds 61 vtfkpyvnvk ysaklgddni vdvekkllsf lpkddvivrd eakwvdcfae erkthnlsdv 121 fekvseysln geefvvykss lvddfarrmh rrvqifsllf ieaanyidet dpswqiywll 181 nkktkeligf vttykywhyl gaksfdedid kkfrakisqf lifppyqnkg hgsclyeaii 241 qswledksit eitvedpnea fddlrdrndi qrlrklgyda vfqkhsdlsd eflessrksl 301 kleerqfnrl vemllllnns psfelkvknr lyiknydald qtdpekarea lqnsfilvkd 361 dyrriiesin ksqg // LOCUS NP_015325 486 aa linear PLN 30-JUN-2025 DEFINITION citrate (Si)-synthase CIT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015325 VERSION NP_015325.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184098.1 REFERENCE 1 (residues 1 to 486) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 486) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 486) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 486) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 486) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11428. Method: conceptual translation. FEATURES Location/Qualifiers source 1..486 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..486 /product="citrate (Si)-synthase CIT3" /EC_number="2.3.3.1" /calculated_mol_wt="53680" Region 29..474 /region_name="ScCit3_like" /note="Saccharomyces cerevisiae (Sc) 2-methylcitrate synthase Cit3-like. 2-methylcitrate synthase (2MCS) catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxaloacetate (OAA) to form 2-methylcitrate and CoA. Citrate synthase (CS) catalyzes the...; cd06106" /db_xref="CDD:99859" Site order(67..68,71..77,164,168,171,279,284,287..288,291..292, 295..297,301,308..309,312..314,362,462..470) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:99859" Site order(69,279,283,313..316,318,321,355..362,365,370,414,417, 419,441,445,462,465) /site_type="active" /db_xref="CDD:99859" Site order(69,313..315,318,321,355..362,365,414,417,419,462) /site_type="other" /note="coenzyme A binding site [chemical binding]" /db_xref="CDD:99859" Site order(69,279,283,314..315,355..356,358..362,370,417,445) /site_type="other" /note="citrylCoA binding site [chemical binding]" /db_xref="CDD:99859" Site order(279,283,315..316,361..362,370,419,441,445,465) /site_type="other" /note="oxalacetate/citrate binding site [chemical binding]" /db_xref="CDD:99859" Site order(315,361,419) /site_type="active" /note="catalytic triad [active]" /db_xref="CDD:99859" CDS 1..486 /gene="CIT3" /locus_tag="YPR001W" /coded_by="NM_001184098.1:1..1461" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:9140965|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006099 tricarboxylic acid cycle [PMID:17570335]" /experiment="EXISTENCE:direct assay:GO:0036440 citrate synthase activity [PMID:17570335]" /experiment="EXISTENCE:direct assay:GO:0050440 2-methylcitrate synthase activity [PMID:17570335]" /experiment="EXISTENCE:genetic interaction:GO:0019629 propionate catabolic process, 2-methylcitrate cycle [PMID:17570335]" /experiment="EXISTENCE:mutant phenotype:GO:0036440 citrate synthase activity [PMID:17570335]" /experiment="EXISTENCE:mutant phenotype:GO:0050440 2-methylcitrate synthase activity [PMID:17570335]" /note="Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate" /db_xref="GeneID:856107" /db_xref="SGD:S000006205" ORIGIN 1 mvqrllpgah icrrsfnssa iikssaltlk ealenvipkk rdavkklkac ygstfvgpit 61 issvlggmrg nqsmfwqgts ldpehgikfq gltieecqnr lpntgidgdn flpesmlwll 121 mtggvptfqq aasfrkelai rgrklphyte kvlsslpkdm hpmtqlaigl asmnkgslfa 181 tnyqkgligk mefwkdtled slnliaslpl ltgriysnit neghplgqys eevdwctnic 241 sllgmtngtn ssntcnltsq qsldfinlmr lytgihvdhe ggnvsahtth lvgsalsdpy 301 lsyssgimgl agplhglaaq evvrfliemn snissiareq eikdylwkil nsnrvipgyg 361 havlrkpdpr ftamlefaqk rpiefendkn vllmqklaei apkvllehgk sknpfpnvds 421 asgilfyhyg irellfftvi fgcsramgpl tqlvwdrilg lpierpksln leglealtka 481 snvnkl // LOCUS NP_015326 516 aa linear PLN 30-JUN-2025 DEFINITION putative 2-methylcitrate dehydratase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015326 VERSION NP_015326.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184099.1 REFERENCE 1 (residues 1 to 516) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 516) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 516) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 516) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 516) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11429. Method: conceptual translation. FEATURES Location/Qualifiers source 1..516 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..516 /product="putative 2-methylcitrate dehydratase" /EC_number="4.2.1.79" /calculated_mol_wt="57553" Region 27..513 /region_name="prpD" /note="bifunctional 2-methylcitrate dehydratase/aconitate hydratase; PRK09425" /db_xref="CDD:181845" CDS 1..516 /gene="PDH1" /locus_tag="YPR002W" /coded_by="NM_001184099.1:1..1551" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0019541 propionate metabolic process [PMID:11179416]" /note="Putative 2-methylcitrate dehydratase; mitochondrial protein that participates in respiration; induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate" /db_xref="GeneID:856108" /db_xref="SGD:S000006206" ORIGIN 1 mflaknlknn kikvclpkkk faalstasiq tnerpnpdkv lkdiakyvhe tplksslald 61 tarlcfldtl gcglaalkfk qaqniikpiv pgtivpsgtk ilgtsyvmdp vkgafaigtl 121 irwldyndcw laaewghpsd nlggilavad hlsrlnkath gkngkqflvk dvleamikah 181 eiqgiialen sfnkvgldhv vlvkvatagv vskmlglsqe qtiealsqaf vdgqslrtyr 241 hapntgsrks waagdavsra vnlaylvkna nvgtipsvlt artwgfydvl fkgkpfsfqq 301 rskydsyvme nvlfkisfpa efhaqtavea avkayrilak qgktfkdiks irirtqeaam 361 riidksgply nyadrdhciq ymiavplitg nltatdysde varnpeidnl rskmyciedt 421 hltqnyhdpd krsignalli elndgtqlde ifveypvghk frreegipll mnkfqrhlre 481 hfvespdkvd limkvssktn flnmqidkym dlfteg // LOCUS NP_015328 754 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR003C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015328 VERSION NP_015328.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184100.1 REFERENCE 1 (residues 1 to 754) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 754) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 754) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 754) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 754) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11430. Method: conceptual translation. FEATURES Location/Qualifiers source 1..754 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..754 /product="uncharacterized protein" /calculated_mol_wt="83253" Region 119..513 /region_name="Sulfate_transp" /note="Sulfate permease family; pfam00916" /db_xref="CDD:459995" Region 576..690 /region_name="STAS_SulP_like_sulfate_transporter" /note="Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; cd07042" /db_xref="CDD:132913" CDS 1..754 /locus_tag="YPR003C" /coded_by="NM_001184100.1:1..2265" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene" /db_xref="GeneID:856111" /db_xref="SGD:S000006207" ORIGIN 1 mtsnnsllgr grmsysstap prfkrsvdqr dtfsdnfdyd kdssnrgrty iaasnsttgv 61 pppnnsrsgc tnntnntnnt sntsntnnnd svdentvfet lpyylpcfsw lpeytfnklw 121 gdviagisva sfqiplalsy ttsiahvppl cglyslaisp fvygilgsvp qmivgpesai 181 slvvgqaves itlhkenvsl idistvitfv sgtillfsgi srfgflgnvl skallrgfis 241 svglvmiins liselkldkf lvslpqhyht pfekilflid yapaqyhipt aifsgccliv 301 lfltrllkrk lmkyhksaif fpdillvviv tilismkfnl khrygisiig dfsmdnfdel 361 knpltrprrk lipdlfsasl ivamlgffes ttaskslgtt ynltvssnre lvalgfmniv 421 islfgalpaf ggygrskina lsgaqsvmsg vfmgvitlit mnlllqfvhy ipncvlsvit 481 tiigisllee vpgdikfhlr cggfselfvf avtfcttify sieagicigc vysiiniikh 541 saksriqila rvagtsnftn lddymmnmkr nsldvegtee iegcmivrip epltftnsed 601 lkqrldrier ygsskihpgr kslrskdsik yvifdlggmt sidssaaqvl eeiitsykrr 661 nvfiylvnvs indkvrrrlf kagvaasver aqannnennt sntfsdaget yspyfdsida 721 alyeiekmki kgnnvpnnds esfmsntlfn sslv // LOCUS NP_015329 344 aa linear PLN 30-JUN-2025 DEFINITION Aim45p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015329 VERSION NP_015329.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184101.1 REFERENCE 1 (residues 1 to 344) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 344) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 344) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 344) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 344) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11431. Method: conceptual translation. FEATURES Location/Qualifiers source 1..344 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..344 /product="Aim45p" /calculated_mol_wt="36672" Region 49..344 /region_name="FixB" /note="Electron transfer flavoprotein, alpha subunit FixB [Energy production and conversion]; COG2025" /db_xref="CDD:441628" CDS 1..344 /gene="AIM45" /locus_tag="YPR004C" /coded_by="NM_001184101.1:1..1035" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:11502169|PMID:17054397|P MID:16823961|PMID:24769239]" /note="Putative ortholog of mammalian ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response; ETF-alpha is an electron transfer flavoprotein complex subunit" /db_xref="GeneID:856112" /db_xref="SGD:S000006208" ORIGIN 1 mfkslaavlp raskakflqk nyastlafie sskdgsvsrs slsllaaaqk lsnpitavit 61 gskaektaea lkssyscsnl eklvifedsk ldtclpeqlt pllvkllkgg dyshfvvsns 121 svgksvlprv galldvqpvc evtvikdpkt firpiyagni istiecqaek klliirasaf 181 ppiaegsmds vtiekrtdip pcdlnvtwvk tiltkserpe ltsaqnvvtg gralkdketf 241 ekllspladv lhaaigatra svdnglcdns lqigqtgkvv apnlyiaigv sgavqhlagm 301 kdskvivain ndpdapifnv adyglqgdly kivpeltekl gkyk // LOCUS NP_015330 294 aa linear PLN 30-JUN-2025 DEFINITION Hal1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015330 VERSION NP_015330.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184102.1 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11432. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..294 /product="Hal1p" /calculated_mol_wt="32863" CDS 1..294 /gene="HAL1" /locus_tag="YPR005C" /coded_by="NM_001184102.1:1..885" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:1505513]" /experiment="EXISTENCE:mutant phenotype:GO:0009651 response to salt stress [PMID:1505513]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:1505513]" /note="Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p" /db_xref="GeneID:856113" /db_xref="SGD:S000006209" ORIGIN 1 mhfkdlglhd ytlknlmyen ncckfydavd ennisyvlkf vpsdvtsegd tfpfvdrfqv 61 kegvflvyss ndfgkegtdy ftytgsggne vhisgtssea gikpqfietc hpkhlkrgtk 121 eqedinssts kksavinnfs gektpnprpq ssniserety vgilnvkckn knsskirsek 181 lvssvietkh tpglasilsk egttypnnad gkhisivnps skiyhsshkq ivktpipksg 241 lspiercpfn gqnikcyspr pldhespqrd fnnnfqlril kssvlqrrqs tqns // LOCUS NP_015331 575 aa linear PLN 30-JUN-2025 DEFINITION methylisocitrate lyase ICL2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015331 VERSION NP_015331.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184103.1 REFERENCE 1 (residues 1 to 575) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 575) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 575) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 575) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 575) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11433. Method: conceptual translation. FEATURES Location/Qualifiers source 1..575 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..575 /product="methylisocitrate lyase ICL2" /EC_number="4.1.3.30" /calculated_mol_wt="64845" Region 45..575 /region_name="TIM-like beta/alpha barrel domains" /note="A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure; cl21457" /db_xref="CDD:473867" CDS 1..575 /gene="ICL2" /locus_tag="YPR006C" /coded_by="NM_001184103.1:1..1728" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:11092862]" /experiment="EXISTENCE:direct assay:GO:0019629 propionate catabolic process, 2-methylcitrate cycle [PMID:11092862]" /experiment="EXISTENCE:direct assay:GO:0046421 methylisocitrate lyase activity [PMID:11092862]" /note="2-methylisocitrate lyase of the mitochondrial matrix; functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol" /db_xref="GeneID:856114" /db_xref="SGD:S000006210" ORIGIN 1 mitminnktf nrkttgtlkk lvlssdkslr rsfngasstk dfvfsesskv eewwesarfk 61 nisrpysatd vvkhrgslpa ntsiypssyq arklfnllee nfkngtplht lgvidpvqms 121 qlarcrnikv ayisgwacss tlvgstnevs pdfgdypydt vpnqverifk aqqlhdrkaf 181 leasikgstp vdylkpiiad admghggptt vmkvaklfae kgaagihled qmvggkrcgh 241 lsgavlvpta thlmrlistr fqwdimgten lviartdscn gkllssssdp rdhefirgii 301 rdnvvpwsek liemedkkip nsaiadmeke wyhenelftf eealekqfta sefesykekk 361 edlmvnklgr aylslremkl laqevtplkk iifdwdaprt kegyymfngc ieaairrslv 421 fapysdmiwl etktpdleqa rsfsrkihkq lpatklvynl spsfnwsahg fddkalksfv 481 wdlakegftl qlvslaglhs dgvsfwelan sfqsdgmkay vekvqkreke tncdimthql 541 wsgaeyvdsl mkvvqngass qtlstsgesf tetqf // LOCUS NP_015332 680 aa linear PLN 30-JUN-2025 DEFINITION Rec8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015332 VERSION NP_015332.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184104.1 REFERENCE 1 (residues 1 to 680) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 680) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 680) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 680) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 680) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 680) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 680) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11434. Method: conceptual translation. FEATURES Location/Qualifiers source 1..680 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..680 /product="Rec8p" /calculated_mol_wt="77071" Region 12..120 /region_name="Rad21_Rec8_N" /note="N terminus of Rad21 / Rec8 like protein; pfam04825" /db_xref="CDD:461446" Region 574..679 /region_name="Rad21_Rec8_M_ScRec8p-like" /note="Middle HEAT-repeat binding domain found in Saccharomyces cerevisiae meiotic recombination protein Rec8 (ScRec8p) and similar proteins; cd21790" /db_xref="CDD:439292" Site order(580..590,593,596..597,610..617,641,644..649,671..672, 674..679) /site_type="other" /note="putative HEAT-repeat binding site [polypeptide binding]" /db_xref="CDD:439292" CDS 1..680 /gene="REC8" /locus_tag="YPR007C" /gene_synonym="SPO69" /coded_by="NM_001184104.1:1..2043" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:23246437]" /experiment="EXISTENCE:direct assay:GO:0000779 condensed chromosome, centromeric region [PMID:10412984|PMID:16357219]" /experiment="EXISTENCE:direct assay:GO:0000794 condensed nuclear chromosome [PMID:16357219]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:23246437]" /experiment="EXISTENCE:genetic interaction:GO:0071459 protein localization to chromosome, centromeric region [PMID:16357219]" /experiment="EXISTENCE:mutant phenotype:GO:0007130 synaptonemal complex assembly [PMID:10412984]" /experiment="EXISTENCE:mutant phenotype:GO:0007131 reciprocal meiotic recombination [PMID:10412984]" /experiment="EXISTENCE:mutant phenotype:GO:0042138 meiotic DNA double-strand break formation [PMID:31617566]" /experiment="EXISTENCE:mutant phenotype:GO:0051177 meiotic sister chromatid cohesion [PMID:10412984]" /note="Meiosis-specific component of the sister chromatid cohesion complex; alpha-kleisin family member that maintains cohesion between homologous chromosomes during meiosis I until chromosome arm-associated Rec8p is cleaved by Esp1p; cohesion between sister chromatid centromeres is maintained until metaphase of meiosis II when it is cleaved by Esp1; independent of the role in cohesion, Rec8p promotes allelic collisions and prevents nonspecific chromosome interactions; homolog of S. pombe Rec8p" /db_xref="GeneID:856115" /db_xref="SGD:S000006211" ORIGIN 1 maplslnfkd dkkykglttv wllsalgnsi vkesnnyysn ksnstgniss stvkkkdivn 61 isipktcdei qnfendfslr yisnllygvt icynkkteyv lndlnhllvq lqkndvyafk 121 aknkstring lnsnnsiign knnnytweec vffdddplyd itkvpalefl nttlqdnvsf 181 ieeaksirrq dyinelsnsn rfelhgdmtn sdaqsnlgsn vrnsfpldei pvdvdfnldl 241 ddivshqgtp lgshsssqkd gndfkfnyqg delvlnfend nennsngged tsvenegpva 301 nlkdyelgle aqaseeendl qqklntrmqr ghradvggqf skvqfdakts ypnevlkfnh 361 gnyshlmekn rirkltgqnf ltsnisslvr scgeeeffst nwlsifndfs niktsewdly 421 pqgfssverg rkrahslvst qsssstrshe ygrksfrnnk ndnyssdmen dnlllnleqi 481 nedledghyi eensqgnild fnlnlppssf grshtrnstr ssgfnedivg alrrrvgpse 541 qnfaeeddss nscfsdgsqq nlqqdktnfq dvildyqtkk fydyikersi vvgrttrsnp 601 pfkrkmllvd iipsrmgeaq tganfddver gvsrqiaasa flsllnlatk gmvklneypv 661 adavtkdlkl rredeiivya // LOCUS NP_015333 694 aa linear PLN 30-JUN-2025 DEFINITION Haa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015333 VERSION NP_015333.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184105.1 REFERENCE 1 (residues 1 to 694) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 694) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 694) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 694) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 694) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11435. Method: conceptual translation. FEATURES Location/Qualifiers source 1..694 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..694 /product="Haa1p" /calculated_mol_wt="76540" Region 2..40 /region_name="Cu_FIST" /note="Copper-Fist; smart00412" /db_xref="CDD:128690" CDS 1..694 /gene="HAA1" /locus_tag="YPR008W" /coded_by="NM_001184105.1:1..2085" /experiment="EXISTENCE:direct assay:GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific [PMID:21586585]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11504737]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11504737]" /experiment="EXISTENCE:mutant phenotype:GO:0033554 cellular response to stress [PMID:16176797]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:16176797|PMID:16980434|PMID:28068993|PMID:11504737]" /experiment="EXISTENCE:mutant phenotype:GO:0071468 cellular response to acidic pH [PMID:28068993|PMID:16980434]" /note="Transcriptional activator involved in adaptation to weak acid stress; activates transcription of TPO2, YRO2, and other genes encoding membrane stress proteins; HAA1 has a paralog, CUP2, that arose from the whole genome duplication; relocalizes from cytoplasm to nucleus upon DNA replication stress" /db_xref="GeneID:856117" /db_xref="SGD:S000006212" ORIGIN 1 mvlingikya cercirghrv ttcnhtdqpl mmikpkgrps ttcdyckqlr knknanpegv 61 ctcgrlekkk laqkakeear akakekqrkq ctcgtdevck yhaqkrhlrk spsssqkkgr 121 sisrsqpmfe rvlsstslds nmlsghgals dtssiltstf ldsepgvgki skdyhhvpsl 181 asisslqssq sldqnfsipq spplssmsfn fltgninetn qnhsnhqhsk sgnnwqdssv 241 slpakadsrl nmmdknnsvg ldllghskri spisnsrvge vsvpleeyip sdidgvgrvt 301 dksslvydwp fdesiernfs ttataatges kfdindncnr insksysktn smngngmnns 361 nnnninsngn dknnnnssrq ehqgnglfdm ftdsssistl sranlllqek igsqensvkq 421 enysknpqlr hqltsrsrsf ihhpaneylk ntfgnshsnd igkgvevlsl tpsfmdipek 481 ereterspss nyitdrpftr kprsssidvn hryppmaptt vatspgalnn avasnlddql 541 sltslnsqps sianmmmdps nlaeqssihs vpqsinsprm pktgsrqdkn ihtkkeernp 601 lnnihdlsql envpdemnqm fspplksmnr pdairensss snfiiqgnsm istpsgrndl 661 pdtspmssiq tasppsqllt dqgfadldnf mssl // LOCUS NP_015334 268 aa linear PLN 30-JUN-2025 DEFINITION Sut2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015334 VERSION NP_015334.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184106.1 REFERENCE 1 (residues 1 to 268) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 268) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 268) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 268) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11436. Method: conceptual translation. FEATURES Location/Qualifiers source 1..268 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..268 /product="Sut2p" /calculated_mol_wt="30127" CDS 1..268 /gene="SUT2" /locus_tag="YPR009W" /coded_by="NM_001184106.1:1..807" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15030478]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:23872066]" /experiment="EXISTENCE:genetic interaction:GO:1900237 positive regulation of induction of conjugation with cellular fusion [PMID:23872066]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:26448198|PMID:23872066]" /experiment="EXISTENCE:mutant phenotype:GO:0009267 cellular response to starvation [PMID:26448198]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:11248676]" /experiment="EXISTENCE:mutant phenotype:GO:1900237 positive regulation of induction of conjugation with cellular fusion [PMID:23872066]" /experiment="EXISTENCE:mutant phenotype:GO:1900429 negative regulation of filamentous growth of a population of unicellular organisms [PMID:26448198]" /experiment="EXISTENCE:mutant phenotype:GO:2000911 positive regulation of sterol import [PMID:11248676]" /note="Zn2Cys6 family transcription factor; positively regulates sterol uptake under anaerobic conditions with SUT1; represses filamentation-inducing genes during non-starvation conditions; positively regulates mating along with SUT1 by repressing the expression of genes (PRR2, NCE102 and RHO5) which function as mating inhibitors; multicopy suppressor of mutations that cause low activity of the cAMP/PKA pathway; SUT2 has a paralog, SUT1, that arose from the whole genome duplication" /db_xref="GeneID:856118" /db_xref="SGD:S000006213" ORIGIN 1 mkpnnrtcdv itnkdeslpa lllpalnsyt cddsllkgqi ssngryqpfg fsdcsllpkr 61 lniqagqgsm pvssiqcadh sysnwqkese ktklpklgcp teyteyyktv ssgettdsav 121 vssiatnrlk rkrqrdgpsc dscrikkikc natiiiflqd rnlississn lhytlsqddi 181 nqfrmkffrk lpdvmgtyev ikhldkivlf kactscsrrn qkngkclfsr gftksdmnvf 241 pkinsklkdk sifemtvddy vaagfqtl // LOCUS NP_015335 1203 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase I core subunit RPA135 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015335 VERSION NP_015335.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184107.1 REFERENCE 1 (residues 1 to 1203) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1203) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1203) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1203) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1203) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11437. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1203 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1203 /product="DNA-directed RNA polymerase I core subunit RPA135" /EC_number="2.7.7.6" /calculated_mol_wt="135611" Region 42..1199 /region_name="RNA_pol_B_RPB2" /note="RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; cd00653" /db_xref="CDD:238353" Site order(129,800,841,843,847..849,851) /site_type="other" /note="RPB12 interaction site [polypeptide binding]" /db_xref="CDD:238353" Region 210..403 /region_name="RNA_pol_Rpb2_2" /note="RNA polymerase Rpb2, domain 2; pfam04561" /db_xref="CDD:398318" Site order(516,518..520,522,525,530,690,708..710,712,775..778, 781,783..785,924,926,928,950,952,955,958,963,967,984,1015, 1023..1025,1027,1040,1043..1045,1047..1048,1069..1071,1075, 1077..1078,1080,1082..1087,1089..1094,1098,1179,1183,1185, 1187..1188,1190,1192..1195,1197,1199) /site_type="other" /note="RPB1 interaction site [polypeptide binding]" /db_xref="CDD:238353" Region 593..651 /region_name="RNA_pol_Rpa2_4" /note="RNA polymerase I, Rpa2 specific domain; pfam06883" /db_xref="CDD:462028" Site order(748..749,770,772,793,796,933,946,973..974,976,1011, 1028) /site_type="other" /note="RPB10 interaction site [polypeptide binding]" /db_xref="CDD:238353" Site order(781,795,932,1017) /site_type="other" /note="RPB11 interaction site [polypeptide binding]" /db_xref="CDD:238353" Site order(795..796,800,906,908,933..935,938,940..941, 1016..1023,1025) /site_type="other" /note="RPB3 interaction site [polypeptide binding]" /db_xref="CDD:238353" CDS 1..1203 /gene="RPA135" /locus_tag="YPR010C" /gene_synonym="RPA2; RRN2; SRP3" /coded_by="NM_001184107.1:1..3612" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:genetic interaction:GO:0042790 nucleolar large rRNA transcription by RNA polymerase I [PMID:2023944]" /note="RNA polymerase I second largest subunit A135" /db_xref="GeneID:856119" /db_xref="SGD:S000006214" ORIGIN 1 mskvikppgq artadfrtle resrfinppk dksafpllqe avqphigsfn altegpdggl 61 lnlgvkdige kvifdgkpln sedeisnsgy lgnklsvsve qvsiakpmsn dgvssaverk 121 vypsesrqrl tsyrgklllk lkwsvnngee nlfevrdcgg lpvmlqsnrc hlnkmspyel 181 vqhkeesdei ggyfivngie klirmlivqr rnhpmaiirp sfanrgasys hygiqirsvr 241 pdqtsqtnvl hylndgqvtf rfswrkneyl vpvvmilkal chtsdreifd giigndvkds 301 fltdrlelll rgfkkryphl qnrtqvlqyl gdkfrvvfqa spdqsdlevg qevldrivlv 361 hlgkdgsqdk frmllfmirk lyslvagecs pdnpdatqhq evllggflyg milkekidey 421 lqniiaqvrm dinrgmainf kdkrymsrvl mrvnenigsk mqyflstgnl vsqsgldlqq 481 vsgytvvaek infyrfishf rmvhrgsffa qlktttvrkl lpeswgflcp vhtpdgspcg 541 llnhfahkcr istqqsdvsr ipsilyslgv apashtfaag pslccvqidg kiigwvsheq 601 gkiiadtlry wkvegktpgl pidleigyvp pstrgqypgl ylfgghsrml rpvrylpldk 661 edivgpfeqv ymniavtpqe iqnnvhthve ftptnilsil anltpfsdfn qsprnmyqcq 721 mgkqtmgtpg valchrsdnk lyrlqtgqtp ivkanlyddy gmdnfpngfn avvavisytg 781 ydmddamiin ksadergfgy gtmyktekvd lalnrnrgdp itqhfgfgnd ewpkewlekl 841 dedglpyigt yveegdpica yfddtlnktk iktyhssepa yieevnligd esnkfqelqt 901 vsikyrirrt pqigdkfssr hgqkgvcsrk wptidmpfse tgiqpdiiin phafpsrmti 961 gmfveslagk agalhgiaqd stpwifnedd tpadyfgeql akagynyhgn epmysgatge 1021 elradiyvgv vyyqrlrhmv ndkfqvrstg pvnsltmqpv kgrkrhggir vgemerdali 1081 ghgtsfllqd rllnssdytq asvcrecgsi lttqqsvpri gsistvccrr csmrfedakk 1141 lltksedgek ifiddsqiwe dgqgnkfvgg netttvaipf vlkyldsels amgirlrynv 1201 epk // LOCUS NP_001091638 72 aa linear PLN 30-JUN-2025 DEFINITION Mra1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001091638 VERSION NP_001091638.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184689.1 REFERENCE 1 (residues 1 to 72) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 72) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 72) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 72) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 72) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11438. Method: conceptual translation. FEATURES Location/Qualifiers source 1..72 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..72 /product="Mra1p" /calculated_mol_wt="7771" CDS 1..72 /gene="MRA1" /locus_tag="YPR010C-A" /gene_synonym="MIN8" /coded_by="NM_001184689.1:1..219" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:38508182]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0031333 negative regulation of protein-containing complex assembly [PMID:38508182]" /note="Protein that negatively regulates respiratory complex assembly; associated with the inner mitochondrial membrane; antagonistic with Rcf2p to control ETC assembly; conserved among Saccharomyces sensu stricto species" /db_xref="GeneID:5142379" /db_xref="SGD:S000122558" ORIGIN 1 mrpaqlllnt akktsggyki pveltplfla vgvalcsgty ftykklrtde tlrltgnpel 61 ssldevlakd kd // LOCUS NP_015336 326 aa linear PLN 30-JUN-2025 DEFINITION Mrx21p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015336 VERSION NP_015336.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184108.1 REFERENCE 1 (residues 1 to 326) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 326) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 326) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 326) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 326) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11439. Method: conceptual translation. FEATURES Location/Qualifiers source 1..326 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..326 /product="Mrx21p" /calculated_mol_wt="35782" Region 26..304 /region_name="PTZ00169" /note="ADP/ATP transporter on adenylate translocase; Provisional" /db_xref="CDD:240302" CDS 1..326 /gene="MRX21" /locus_tag="YPR011C" /coded_by="NM_001184108.1:1..981" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0046964 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity [PMID:24296033]" /experiment="EXISTENCE:direct assay:GO:1902557 5'-adenylyl sulfate transmembrane transporter activity [PMID:24296033]" /experiment="EXISTENCE:direct assay:GO:1902558 5'-adenylyl sulfate transmembrane transport [PMID:24296033]" /experiment="EXISTENCE:direct assay:GO:1902559 3'-phospho-5'-adenylyl sulfate transmembrane transport [PMID:24296033]" /note="Mitochondrial transporter; major substrates are adenosine 5'-phosphosulfate (APS) and 3'-phospho-adenosine 5'-phosphosulfate (PAPS); member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies" /db_xref="GeneID:856121" /db_xref="SGD:S000006215" ORIGIN 1 maevltvleq pnsikdflkq dsniaflagg vagavsrtvv spfervkill qvqssttsyn 61 rgifssirqv yheegtkglf rgnglnciri fpysavqfvv yeackkklfh vngnngqeql 121 tntqrlfsga lcggcsvvat ypldliktrl siqtanlssl nrskaksisk ppgiwqllse 181 tyrlegglrg lyrgvwptsl gvvpyvalnf avyeqlrefg vnssdaqpsw ksnlykltig 241 aisggvaqti typfdllrrr fqvlamggne lgfrytsvwd alvtigraeg vsgyykglaa 301 nlfkvvpsta vswlvyevvc dsvrnw // LOCUS NP_015338 317 aa linear PLN 30-JUN-2025 DEFINITION Cmr3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015338 VERSION NP_015338.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184110.1 REFERENCE 1 (residues 1 to 317) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 317) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 317) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 317) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 317) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11440. Method: conceptual translation. FEATURES Location/Qualifiers source 1..317 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..317 /product="Cmr3p" /calculated_mol_wt="35227" Region 17..316 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 256..276 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275370" Site order(261,263,265,267..268,271..272,275,291,293..295, 297..298,302,305) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275370" Region 284..306 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275370" CDS 1..317 /gene="CMR3" /locus_tag="YPR013C" /coded_by="NM_001184110.1:1..954" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:23012409]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363]" /note="Putative zinc finger protein; YPR013C is not an essential gene" /db_xref="GeneID:856123" /db_xref="SGD:S000006217" ORIGIN 1 mnfslskqss ekqssytdks rspnigmctv nyksnlplqv savdqlstgk gtqfyghnsy 61 knerecynst kinlppissl lpnfenntpp nvdsrvqfpp qqvyqsmnvv pivneiytpi 121 smnatsdqyp iyytesqqpi phsqsphlts saplmmpvmv ptvykpltpy dkepitiase 181 pnftaismas hpnaalelch drpksvppgy gvlptmqeas ngrtksepga vlngsatfsd 241 wktdtrisst klrkqcpvcg kicsrpstlk thylihtgdt pfkctwegct ksfnvksnml 301 rhlksherkr nkvlntt // LOCUS NP_001335824 109 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR014C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335824 VERSION NP_001335824.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348886.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80344. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..109 /product="uncharacterized protein" /calculated_mol_wt="12053" CDS 1..109 /locus_tag="YPR014C" /coded_by="NM_001348886.1:1..330" /note="hypothetical protein; conserved across S. cerevisiae strains; YPR014C is not an essential gene" /db_xref="GeneID:856124" /db_xref="SGD:S000006218" ORIGIN 1 mscifsadlg veyscaesri tnlvlcilci reekaapvvk kdkflffifl sskenlfcei 61 ssrssvsevk slraknnfic phavigfqga kaqlgirfpq lngllrlqh // LOCUS NP_015340 247 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR015C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015340 VERSION NP_015340.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184112.1 REFERENCE 1 (residues 1 to 247) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 247) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 247) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 247) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 247) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11441. Method: conceptual translation. FEATURES Location/Qualifiers source 1..247 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..247 /product="uncharacterized protein" /calculated_mol_wt="27644" Region <17..247 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 187..207 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275370" Site order(192,194,196,198..199,202..203,206,222,224..226, 228..229,233,236) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275370" Region 215..237 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275370" CDS 1..247 /locus_tag="YPR015C" /coded_by="NM_001184112.1:1..744" /experiment="EXISTENCE:mutant phenotype:GO:0000077 DNA damage checkpoint signaling [PMID:18617996]" /note="Putative zinc finger transcription factor; binds DNA in sequence-specific manner; overexpression causes a cell cycle delay or arrest" /db_xref="GeneID:856125" /db_xref="SGD:S000006219" ORIGIN 1 mwrtktlesm lcspmkcsss niggsyaqss kevsnttkre vhlppcssim hapltpeinq 61 aalpppayhy apsslhqted pvwrsspnsi ifspviatpq pfpltfverq sccpiystaa 121 ssytaqsvpp smqhfqeenh ravsneqysl pnvhigqnpg tllsqtqtdl dliqkqlrav 181 vklrkqcpic gkvcsrpstl rthylihtgd tpfkctwehc nksfnvksnm lrhlrthqkk 241 iakkkhq // LOCUS NP_015341 245 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor 6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015341 VERSION NP_015341.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184113.1 REFERENCE 1 (residues 1 to 245) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 245) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 245) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 245) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 245) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11442. Method: conceptual translation. FEATURES Location/Qualifiers source 1..245 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..245 /product="translation initiation factor 6" /calculated_mol_wt="26327" Region 1..245 /region_name="PTZ00136" /note="eukaryotic translation initiation factor 6-like protein; Provisional" /db_xref="CDD:185471" Site order(2..4,203..207) /site_type="other" /note="'Velcro' closure" /db_xref="CDD:238292" CDS 1..245 /gene="TIF6" /locus_tag="YPR016C" /gene_synonym="CDC95" /coded_by="NM_001184113.1:1..738" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11238882]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:17353896]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11238882]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:11583614|PMID:23212245|PMID:16188229|PMID:17443350]" /experiment="EXISTENCE:direct assay:GO:0043023 ribosomal large subunit binding [PMID:9891075]" /experiment="EXISTENCE:genetic interaction:GO:0000054 ribosomal subunit export from nucleus [PMID:17353896]" /experiment="EXISTENCE:genetic interaction:GO:0006364 rRNA processing [PMID:17353896]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11238882]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11238882]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:11238882|PMID:10206977]" /experiment="EXISTENCE:mutant phenotype:GO:1902626 assembly of large subunit precursor of preribosome [PMID:22735702]" /note="Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits" /db_xref="GeneID:856126" /db_xref="SGD:S000006220" ORIGIN 1 matrtqfens neigvfsklt ntyclvavgg senfysafea elgdaipivh ttiagtriig 61 rmtagnrrgl lvptqttdqe lqhlrnslpd svkiqrveer lsalgnvicc ndyvalvhpd 121 idreteelis dvlgvevfrq tisgnilvgs ycslsnqggl vhpqtsvqdq eelssllqvp 181 lvagtvnrgs svvgagmvvn dylavtgldt tapelsvies ifrlqdaqpe sisgnlrdtl 241 ietys // LOCUS NP_015342 143 aa linear PLN 30-JUN-2025 DEFINITION guanine nucleotide exchange factor DSS4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015342 VERSION NP_015342.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184114.1 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11443. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..143 /product="guanine nucleotide exchange factor DSS4" /calculated_mol_wt="15995" Region 2..136 /region_name="RabGEF" /note="Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport; cd00246" /db_xref="CDD:238150" Site order(6,11,104,107) /site_type="other" /note="zinc binding site [ion binding]" /db_xref="CDD:238150" Site order(57..59,63,106) /site_type="other" /note="putative Rab GTPase interaction site [polypeptide binding]" /db_xref="CDD:238150" CDS 1..143 /gene="DSS4" /locus_tag="YPR017C" /coded_by="NM_001184114.1:1..432" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:9218467]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762|PMID:9218467]" /experiment="EXISTENCE:direct assay:GO:0008270 zinc ion binding [PMID:9218467]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:9218467]" /experiment="EXISTENCE:genetic interaction:GO:0006892 post-Golgi vesicle-mediated transport [PMID:9218467|PMID:8429886]" /experiment="EXISTENCE:mutant phenotype:GO:0006892 post-Golgi vesicle-mediated transport [PMID:9218467|PMID:8429886]" /experiment="EXISTENCE:physical interaction:GO:0006892 post-Golgi vesicle-mediated transport [PMID:9218467]" /note="Guanine nucleotide dissociation stimulator for Sec4p; functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol" /db_xref="GeneID:856128" /db_xref="SGD:S000006221" ORIGIN 1 mskatcsfeg chsavitind dniinlpeqv hsefkllenr tmrdatpses nflvvpdvwd 61 fdnvgvsrei pssilgdlsd ksdfvfeygn sswkikkclk ylicadcdkg pigiickvqd 121 qtkneervlh llslrslqim grn // LOCUS NP_015343 606 aa linear PLN 30-JUN-2025 DEFINITION Rlf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015343 VERSION NP_015343.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184115.1 REFERENCE 1 (residues 1 to 606) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 606) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 606) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 606) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 606) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11444. Method: conceptual translation. FEATURES Location/Qualifiers source 1..606 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..606 /product="Rlf2p" /calculated_mol_wt="70079" Region 345..>387 /region_name="CAF1A" /note="Chromatin assembly factor 1 subunit A; pfam12253" /db_xref="CDD:463507" CDS 1..606 /gene="RLF2" /locus_tag="YPR018W" /gene_synonym="CAC1" /coded_by="NM_001184115.1:1..1821" /experiment="EXISTENCE:direct assay:GO:0000775 chromosome, centromeric region [PMID:11782447]" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:25602519]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9030688]" /experiment="EXISTENCE:direct assay:GO:0006335 DNA replication-dependent chromatin assembly [PMID:9030687]" /experiment="EXISTENCE:direct assay:GO:0033186 CAF-1 complex [PMID:9030687]" /experiment="EXISTENCE:direct assay:GO:0042393 histone binding [PMID:16503640]" /experiment="EXISTENCE:mutant phenotype:GO:0006335 DNA replication-dependent chromatin assembly [PMID:9030688]" /note="Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including histone H3/H4 tetramerization, silencing at telomeres, mating type loci and rDNA, maintenance of kinetochore structure, deactivation of DNA damage checkpoint after DNA repair, chromatin dynamics during transcription, and repression of divergent noncoding transcription" /db_xref="GeneID:856129" /db_xref="SGD:S000006222" ORIGIN 1 meqhlksipl qddtkkkgil sffqntttvk snkfltkekd vitlddpked vsgpmietvk 61 qetmksinke cademkttpk kanaedkllc yknspiqstk ydrntnkqvp ngniiaietk 121 srssspcskr elssskkeea krekelkkqq raeekhrkel lrqeekkkke lkveeerqrr 181 aelkkqkeee krrkeearle akrrkeeerl kkeeeirlke eakeraqsri gnffkklsds 241 ntpvveksdy ekfflpfyak dgvrvsnkwk ltkvelegsk rkiddellns kdktssddll 301 nwlqsrrlpr ghkikrkavd vlqqmplkek tddelqslla qvphkyikfy envrppfigt 361 ysmdftlppn dpfstkgtgf nydydsdvew vneeeegevd nlesgeeeee eeddedvpse 421 gefdgfldse ensdldglpc akrkfvgpli pticlksnfe nlseenkryl qqlkaeviie 481 tdgpidpfke pktsslpskr snsdlqaqta sqsqspekkq kamitdpmdl lrlfdgvqds 541 tfslgtvtei aqknlpqynk qtikntikey airssgkgdl prkwvikdaq nwenlranan 601 mptpsl // LOCUS NP_015344 933 aa linear PLN 30-JUN-2025 DEFINITION MCM DNA helicase complex subunit MCM4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015344 VERSION NP_015344.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184116.1 REFERENCE 1 (residues 1 to 933) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 933) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 933) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 933) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 933) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 933) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 933) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11445. Method: conceptual translation. FEATURES Location/Qualifiers source 1..933 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..933 /product="MCM DNA helicase complex subunit MCM4" /EC_number="3.6.4.12" /calculated_mol_wt="104873" Region 194..307 /region_name="MCM_N" /note="MCM N-terminal domain; pfam14551" /db_xref="CDD:464206" Region 310..834 /region_name="MCM" /note="minichromosome maintenance proteins; smart00350" /db_xref="CDD:214631" Site order(528,550,570..571,576,579,583,590..592,594..595, 597..598,600,604,609,616..618,622,625,633,636,643,646..647, 651,655,657..659,661..664,666,676,680..681,697,710, 717..718,721,725..726,728..729,762,767,770..771,774,778, 794..795,798..799,802) /site_type="other" /note="oligomer interface [polypeptide binding]" /db_xref="CDD:350661" Site order(529..531,570..576,650,701,720,724,795..796) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:350661" Site order(597,599,604,609,658..659) /site_type="other" /note="nucleic acid binding site [nucleotide binding]" /db_xref="CDD:350661" CDS 1..933 /gene="MCM4" /locus_tag="YPR019W" /gene_synonym="CDC54; HCD21" /coded_by="NM_001184116.1:1..2802" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:15723534]" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194|PMID:11756674]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10704410|PMID:10559985]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:9335335|PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:10559985|PMID:10704410]" /experiment="EXISTENCE:direct assay:GO:0006260 DNA replication [PMID:13679365|PMID:15723534]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0009378 four-way junction helicase activity [PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:0017116 single-stranded DNA helicase activity [PMID:15723534|PMID:18657510]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:direct assay:GO:0042555 MCM complex [PMID:12480933]" /experiment="EXISTENCE:direct assay:GO:0043138 3'-5' DNA helicase activity [PMID:13679365]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16103218]" /experiment="EXISTENCE:direct assay:GO:0071162 CMG complex [PMID:26524492]" /experiment="EXISTENCE:direct assay:GO:0097373 MCM core complex [PMID:13679365]" /experiment="EXISTENCE:genetic interaction:GO:0006270 DNA replication initiation [PMID:2044962]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0003697 single-stranded DNA binding [PMID:17895243]" /experiment="EXISTENCE:mutant phenotype:GO:0006271 DNA strand elongation involved in DNA replication [PMID:10834843]" /experiment="EXISTENCE:mutant phenotype:GO:0033260 nuclear DNA replication [PMID:2044962]" /note="Essential helicase component of heterohexameric MCM2-7 complexes; MCM2-7 complexes bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p" /db_xref="GeneID:856130" /db_xref="SGD:S000006223" ORIGIN 1 msqqsssptk ednnssspvv pnpdsvppql sspalfysss ssqgdiygrn nsqnlsqgeg 61 niraaigssp lnfpsssqrq nsdvfqsqgr qgrirssasa sgrsryhsdl rsdralptss 121 sslgrngqnr vhmrrndiht sdlssprriv dfdtrsgvnt ldtssssapp seaseplrii 181 wgtnvsiqec ttnfrnflms fkykfrkild ereefinntt deelyyikql nemrelgtsn 241 lnldarnlla ykqtedlyhq llnypqevis imdqtikdcm vslivdnnld ydldeietkf 301 ykvrpynvgs ckgmrelnpn didklinlkg lvlrstpvip dmkvaffkcn vcdhtmavei 361 drgviqepar ceridcnepn smslihnrcs fadkqviklq etpdfvpdgq tphsislcvy 421 delvdscrag drievtgtfr sipiransrq rvlkslykty vdvvhvkkvs dkrldvdtst 481 ieqelmqnkv dhneveevrq itdqdlakir evaaredlys llarsiapsi yeledvkkgi 541 llqlfggtnk tftkggryrg dinillcgdp stsksqilqy vhkitprgvy tsgkgssavg 601 ltayitrdvd tkqlvlesga lvlsdggvcc idefdkmsds trsvlhevme qqtisiakag 661 iittlnarss ilasanpigs rynpnlpvte nidlppplls rfdlvylvld kvdekndrel 721 akhltnlyle dkpehisqdd vlpvefltmy isyakehihp iiteaaktel vrayvgmrkm 781 gddsrsdekr itattrqles mirlaeahak mklknvvele dvqeavrlir saikdyatdp 841 ktgkidmnlv qtgksviqrk lqedlsreim nvlkdqasds msfnelikqi nehsqdrves 901 sdiqealsrl qqedkvivlg egvrrsvrln nrv // LOCUS NP_015345 115 aa linear PLN 30-JUN-2025 DEFINITION F1F0 ATP synthase subunit g [Saccharomyces cerevisiae S288C]. ACCESSION NP_015345 VERSION NP_015345.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184117.1 REFERENCE 1 (residues 1 to 115) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 115) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 115) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 115) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11446. Method: conceptual translation. FEATURES Location/Qualifiers source 1..115 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..115 /product="F1F0 ATP synthase subunit g" /calculated_mol_wt="12790" Region 14..112 /region_name="ATP-synt_G" /note="Mitochondrial ATP synthase g subunit; pfam04718" /db_xref="CDD:461408" CDS 1..115 /gene="ATP20" /locus_tag="YPR020W" /coded_by="NM_001184117.1:1..348" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015986 proton motive force-driven ATP synthesis [PMID:20691145]" /experiment="EXISTENCE:direct assay:GO:0046933 proton-transporting ATP synthase activity, rotational mechanism [PMID:20691145]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:20219971|PMID:17761666|PMID:16551625]" /experiment="EXISTENCE:mutant phenotype:GO:0015986 proton motive force-driven ATP synthesis [PMID:10336613|PMID:9857174]" /experiment="EXISTENCE:mutant phenotype:GO:0042407 cristae formation [PMID:19528297]" /experiment="EXISTENCE:mutant phenotype:GO:0045259 proton-transporting ATP synthase complex [PMID:10336613]" /experiment="EXISTENCE:mutant phenotype:GO:0065003 protein-containing complex assembly [PMID:20219971|PMID:17761666|PMID:16551625]" /note="Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determines oligomerization of the complex and the shape of inner membrane cristae" /db_xref="GeneID:856131" /db_xref="SGD:S000006224" ORIGIN 1 mlsriqnyts glvskanlls skalyygkvg aeiskqiylk eglqpptvaq fksvysnlyk 61 qslnfalkpt evlsclkniq knellkygay giqligfysv geiigrrklv gykhh // LOCUS NP_015346 902 aa linear PLN 30-JUN-2025 DEFINITION citrin [Saccharomyces cerevisiae S288C]. ACCESSION NP_015346 VERSION NP_015346.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184118.1 REFERENCE 1 (residues 1 to 902) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 902) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 902) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 902) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 902) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 902) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 902) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11447. Method: conceptual translation. FEATURES Location/Qualifiers source 1..902 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..902 /product="citrin" /calculated_mol_wt="104174" Region 531..619 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 620..713 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 723..814 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..902 /gene="AGC1" /locus_tag="YPR021C" /coded_by="NM_001184118.1:1..2709" /experiment="EXISTENCE:direct assay:GO:0005313 L-glutamate transmembrane transporter activity [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0015183 L-aspartate transmembrane transporter activity [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:0015292 uniporter activity [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:0015297 antiporter activity [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:0015810 aspartate transmembrane transport [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:0015813 L-glutamate transmembrane transport [PMID:14622413]" /experiment="EXISTENCE:direct assay:GO:1990816 vacuole-mitochondrion membrane contact site [PMID:25026036]" /experiment="EXISTENCE:mutant phenotype:GO:0009058 biosynthetic process [PMID:14622413]" /note="Mitochondrial amino acid transporter; acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis; human homolog SLC25A13 complements yeast null mutant" /db_xref="GeneID:856132" /db_xref="SGD:S000006225" ORIGIN 1 meqinsnsrk kkqqlevfky fasvltkedk pisisngmld mptvnssklt agngkpdtek 61 ltgeliltyd dfielisssk tiyskftdhs fnlnqipknv fgciffaide qnkgyltlnd 121 wfyfnnlley dnyhliilye ffrkfdvenl kakqkkelgs ssfnlkaadd riksinygnr 181 flsfddllln lnqfkdtirl lhesiddnfv kdnkllldwn dfrflkfykc yheneeylsl 241 nslvtilqnd lknekifigf drlaqmdsqg hrlalsknql tyllrlfysh rvsadifssl 301 nlsntellka dnnsipynvf kdifylfqnf dllnqifhky vtennlneqd ireqivtknd 361 fmtvlnaqyn kvnniiefsp sqinllfsiv anskenrrlr krnqdrddel lndhhydsdi 421 dffihneylh gvsrsrknle sfndyyhdls dgfdqdsgvk kaskastglf esvfggkkdk 481 atmrsdltie dfmkilnpny lndlvhqmel qknqneslyi nyyfypifds lynfslgsia 541 gcigatvvyp idfiktrmqa qrslaqykns idcllkiisr egikglysgl gpqligvape 601 kaikltvndf mrnrltdkng klslfpeiis gasagacqvi ftnpleivki rlqvqsdyvg 661 eniqqaneta tqivkklglr glyngvaacl mrdvpfsaiy fptyahlkkd lfdfdpndkt 721 krnrlktwel ltagaiagmp aaflttpfdv iktrlqidpr kgetkyngif hairtilkee 781 sfrsffkggg arvlrsspqf gftlaayelf kgfipspdnk lksregrkrf cidddagnee 841 tvvhsngelp qqkfysddrk hanyyykscq iaktfidldn nfsrfdssvy knfqehlrsi 901 ng // LOCUS NP_015347 1133 aa linear PLN 30-JUN-2025 DEFINITION Sdd4p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015347 VERSION NP_015347.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184119.1 REFERENCE 1 (residues 1 to 1133) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1133) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1133) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1133) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1133) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11448. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1133 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1133 /product="Sdd4p" /calculated_mol_wt="129987" Region 33..55 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 63..91 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 506..747 /region_name="Fungal_trans" /note="Fungal specific transcription factor domain; pfam04082" /db_xref="CDD:397964" CDS 1..1133 /gene="SDD4" /locus_tag="YPR022C" /coded_by="NM_001184119.1:1..3402" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS; overproduction of a truncation allele suppresses lethality due to expression of the dominant PET9 allele AAC2-A128P" /db_xref="GeneID:856133" /db_xref="SGD:S000006226" ORIGIN 1 mhgkelagrl rkrendndls pnsssspaer frcphpecnk tfsrqehlsr hklnhwpkei 61 yvcsyvlptt napcnktfvr kdllirhekr hskvknrlsr pskdqisssn kdfsknapyn 121 psevplstqs gtstinlikn svnpppsitq eskfrpflqq aqqpqqvqqs qqpqqiqqlq 181 qlqfpqqlra plqqpmlqqq mhpqqasptf psydprirnn gqngnqffnl ifdnrtgvng 241 fevdaannng ngndqnmnin pavqqqryqd rnfasssyqq plqpltqdqq qeqyfqqqkl 301 aqqqqqqqqq qqqqqqlppq npfgdpltss ssganlsvmq dlfstnflns dplqsfmqel 361 seapqvsied tfsdkntipp nekpvqqdeg fqnppvmfel pqdnikipka qpkfndnpst 421 svkdnlssqk lninelkrrs skdsgvgnns slnykeqlrh smksvpsffh pdpltkykis 481 kekcqemfsf vpelryvsie sihkslksfw lnfhpqygll hkpsfhvdkq pailnlalim 541 tgasflgsey reqisdpicg plrwiifsha dfqppsktyi iqslllvegy ektstnrylh 601 ersflhhgtt iqllrrtpsl gghplmvktg ktsgensiqd pqevykrwid femlkriafy 661 afymdtthav vfgywnlfin snqiqltlpc pdqvwesydl syetlmehgy gstkrdennt 721 flsalmqlmk nviqilrnnn irrnkvnngg iestptdles ttdwniqslf gkkillagii 781 silfqcqeev ngdyfitnfr ggitdhlgls wkdilsfamn ywlhevqksc tdpkacrist 841 pseetltnrk idedngdglc dddldllssd npsnckipvi hisqivlril hhdyyiyaga 901 pwrmnvpigr deydmisrri lqfakdpyng gvavvyafqf lfemfiiken nvptvvksyn 961 insdpvitrp yaialtslli wscnfalhgc evsiwdntea skdecfqpdd snggnilgnt 1021 dnngstiann nlkeknnyip iesfevyllr myrnlyvdss ldvvsfqndv wakasllqhi 1081 snthflcgmm qfmrdifnks ywdlgrefgk lfdnclersl gktsptchnm fdv // LOCUS NP_015348 401 aa linear PLN 30-JUN-2025 DEFINITION Eaf3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015348 VERSION NP_015348.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184120.1 REFERENCE 1 (residues 1 to 401) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 401) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 401) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 401) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 401) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11449. Method: conceptual translation. FEATURES Location/Qualifiers source 1..401 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..401 /product="Eaf3p" /calculated_mol_wt="45072" Region 13..105 /region_name="CD_CSD" /note="CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains; cl28914" /db_xref="CDD:475127" Site order(23..26,79,81..84,88,90..93,95..97,100..101) /site_type="other" /note="putative peptide binding site [polypeptide binding]" /db_xref="CDD:350845" Site order(23,81,84,88) /site_type="other" /note="putative methylated histone tail binding site [chemical binding]" /db_xref="CDD:350845" Site order(78,80..85,87..91) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:350845" Site order(78,81,85,87,91) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:350845" Region 215..378 /region_name="MRG" /note="pfam05712" /db_xref="CDD:461721" CDS 1..401 /gene="EAF3" /locus_tag="YPR023C" /coded_by="NM_001184120.1:1..1206" /experiment="EXISTENCE:direct assay:GO:0000123 histone acetyltransferase complex [PMID:11036083]" /experiment="EXISTENCE:direct assay:GO:0006281 DNA repair [PMID:16135807]" /experiment="EXISTENCE:direct assay:GO:0032221 Rpd3S complex [PMID:16286008|PMID:16286007]" /experiment="EXISTENCE:direct assay:GO:0035267 NuA4 histone acetyltransferase complex [PMID:15485911]" /experiment="EXISTENCE:direct assay:GO:0140003 histone H3K36me3 reader activity [PMID:16364921]" /experiment="EXISTENCE:genetic interaction:GO:0006368 transcription elongation by RNA polymerase II [PMID:19948887]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:11036083]" /experiment="EXISTENCE:mutant phenotype:GO:0030174 regulation of DNA-templated DNA replication initiation [PMID:19417103]" /experiment="EXISTENCE:mutant phenotype:GO:0043487 regulation of RNA stability [PMID:31694990]" /experiment="EXISTENCE:mutant phenotype:GO:0045892 negative regulation of DNA-templated transcription [PMID:16364921]" /experiment="EXISTENCE:mutant phenotype:GO:0060195 negative regulation of antisense RNA transcription [PMID:21248844]" /note="Component of the Rpd3S histone deacetylase complex; Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition" /db_xref="GeneID:856134" /db_xref="SGD:S000006227" ORIGIN 1 mvdleqefal ggrclafhgp lmyeakilki wdpsskmyts ipndkpggss qatkeikpqk 61 lgedesipee iingkcffih yqgwksswde wvgydriray neeniamkkr laneakeakk 121 slleqqkkkk lstslggpsn ggkrkgdsrs nasiskstsq sfltssvsgr ksgrssansl 181 hpgsslrsss dqngnddrrr ssslspnmlh hiagyptpki slqipiklks vlvddweyvt 241 kdkkicrlpa dvtvemvlnk yehevsqele spgsqsqlse ycaglklyfd kclgnmllyr 301 lerlqydell kksskdqkpl vpiriygaih llrlisvlpe lissttmdlq scqllikqte 361 dflvwllmhv deyfndkdpn rsddalyvnt ssqyegvalg m // LOCUS NP_015349 747 aa linear PLN 30-JUN-2025 DEFINITION i-AAA protease YME1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015349 VERSION NP_015349.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184121.1 REFERENCE 1 (residues 1 to 747) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 747) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 747) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 747) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 747) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11450. Method: conceptual translation. FEATURES Location/Qualifiers source 1..747 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..747 /product="i-AAA protease YME1" /calculated_mol_wt="81641" Region <269..709 /region_name="HflB" /note="ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; COG0465" /db_xref="CDD:440233" CDS 1..747 /gene="YME1" /locus_tag="YPR024W" /gene_synonym="OSD1; YTA11" /coded_by="NM_001184121.1:1..2244" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:11914276|PMID:16823961|PMID:14576278|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:8688560|PMID:29138251]" /experiment="EXISTENCE:direct assay:GO:0031942 i-AAA complex [PMID:16267274]" /experiment="EXISTENCE:direct assay:GO:0033619 membrane protein proteolysis [PMID:29138251]" /experiment="EXISTENCE:direct assay:GO:0045041 protein import into mitochondrial intermembrane space [PMID:16966379]" /experiment="EXISTENCE:genetic interaction:GO:0004176 ATP-dependent peptidase activity [PMID:8688560]" /experiment="EXISTENCE:mutant phenotype:GO:0004176 ATP-dependent peptidase activity [PMID:15772085]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:22993211]" /experiment="EXISTENCE:mutant phenotype:GO:0030150 protein import into mitochondrial matrix [PMID:27398316]" /experiment="EXISTENCE:mutant phenotype:GO:0045041 protein import into mitochondrial intermembrane space [PMID:16966379]" /experiment="EXISTENCE:mutant phenotype:GO:0051604 protein maturation [PMID:16966379]" /experiment="EXISTENCE:mutant phenotype:GO:0141164 mitochondrial protein quality control [PMID:18843051]" /note="Catalytic subunit of i-AAA protease complex; complex is located in mitochondrial inner membrane; responsible for degradation of unfolded or misfolded mitochondrial gene products; serves as nonconventional translocation motor to pull PNPase into intermembrane space; also has role in intermembrane space protein folding; mutation causes elevated rate of mitochondrial turnover; human homolog YME1L1 can complement yeast null mutant" /db_xref="GeneID:856135" /db_xref="SGD:S000006228" ORIGIN 1 mnvskilvsp tvttnvlrif aprlpqigas llvqkkwalr skkfyrfyse knsgemppkk 61 eadssgkasn kstissidns qppppsntnd ktkqanvavs hamlatreqe ankdltspda 121 qaafyklllq snypqyvvsr fetpgiassp ecmelymeal qrigrhsead avrqnlltas 181 sagavnpsla ssssnqsgyh gnfpsmyspl ygsrkeplhv vvsestftvv srwvkwllvf 241 giltysfseg fkyitenttl lkssevadks vdvaktnvkf ddvcgcdear aeleeivdfl 301 kdptkyeslg gklpkgvllt gppgtgktll aratageagv dfffmsgsef devyvgvgak 361 rirdlfaqar srapaiifid eldaiggkrn pkdqayakqt lnqllveldg fsqtsgiiii 421 gatnfpeald kaltrpgrfd kvvnvdlpdv rgradilkhh mkkitladnv dptiiargtp 481 glsgaelanl vnqaavyacq knavsvdmsh fewakdkilm gaerktmvlt daarkatafh 541 eaghaimaky tngatplyka tilprgralg itfqlpemdk vditkrecqa rldvcmggki 601 aeeliygkdn ttsgcgsdlq satgtaramv tqygmsddvg pvnlsenwes wsnkirdiad 661 neviellkds eerarrlltk knvelhrlaq glieyetlda heieqvckge kldklktstn 721 tvvegpdsde rkdigddkpk iptmlna // LOCUS NP_015350 393 aa linear PLN 30-JUN-2025 DEFINITION TFIIH complex kinase subunit CCL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015350 VERSION NP_015350.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184122.1 REFERENCE 1 (residues 1 to 393) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 393) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 393) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 393) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 393) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11451. Method: conceptual translation. FEATURES Location/Qualifiers source 1..393 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..393 /product="TFIIH complex kinase subunit CCL1" /calculated_mol_wt="45079" Region 49..376 /region_name="ccl1" /note="cyclin ccl1; TIGR00569" /db_xref="CDD:129660" CDS 1..393 /gene="CCL1" /locus_tag="YPR025C" /coded_by="NM_001184122.1:1..1182" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0070985 transcription factor TFIIK complex [PMID:11839796|PMID:19818408]" /experiment="EXISTENCE:genetic interaction:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:8230216]" /experiment="EXISTENCE:mutant phenotype:GO:0010508 positive regulation of autophagy [PMID:26567215]" /note="Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p; regulates the activity of Kin28p, a TFIIH-associated carboxy-terminal domain (CTD) kinase that facilitates recruitment of mRNA 5'-capping and polyadenylation factors to the RNAPII holoenzyme complex, and has a minor role in RNAPII transcription; subunit of TFIIK, a TFIIH subassembly; human homolog CCNH allows growth of a yeast ccl1 temperature-sensitive mutant at restrictive temperature" /db_xref="GeneID:856136" /db_xref="SGD:S000006229" ORIGIN 1 mtdiqlngks tldtpsatms akekeaklks adennkppny krisdddlyr hssqyrmwsy 61 tkdqlqekrv dtnaraiayi eenllkfrea hnlteeeikv leakaipltm eeeldlvnfy 121 akkvqviaqh lnlptevvat aisffrrffl ensvmqidpk sivhttifla cksenyfisv 181 dsfaqkakst rdsvlkfefk lleslkfsll nhhpykplhg ffldiqnvly gkvdlnymgq 241 iydrckkrit aalltdvvyf ytppqitlat lliedealvt ryletkfpsr egsqesvpgn 301 ekeepqndas tteknkekst eseeysidsa klltiireck siiedckpps teeakkiaak 361 nyycqnpstl iqklkrklng edtsstvekk qkt // LOCUS NP_015351 1211 aa linear PLN 30-JUN-2025 DEFINITION alpha,alpha-trehalase ATH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015351 VERSION NP_015351.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184123.1 REFERENCE 1 (residues 1 to 1211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1211) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11452. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1211 /product="alpha,alpha-trehalase ATH1" /EC_number="3.2.1.28" /calculated_mol_wt="136790" Region 149..>720 /region_name="ATH1" /note="Kojibiose phosphorylase YcjT [Carbohydrate transport and metabolism]; COG1554" /db_xref="CDD:441163" CDS 1..1211 /gene="ATH1" /locus_tag="YPR026W" /coded_by="NM_001184123.1:1..3636" /experiment="EXISTENCE:direct assay:GO:0005993 trehalose catabolic process [PMID:8764988]" /experiment="EXISTENCE:direct assay:GO:0009277 fungal-type cell wall [PMID:15128531]" /experiment="EXISTENCE:direct assay:GO:0030287 cell wall-bounded periplasmic space [PMID:15128531]" /experiment="EXISTENCE:mutant phenotype:GO:0000324 fungal-type vacuole [PMID:7502577]" /experiment="EXISTENCE:mutant phenotype:GO:0004555 alpha,alpha-trehalase activity [PMID:7502577]" /experiment="EXISTENCE:mutant phenotype:GO:0005993 trehalose catabolic process [PMID:7502577|PMID:8764988]" /experiment="EXISTENCE:mutant phenotype:GO:0015771 trehalose transport [PMID:19016884]" /note="Acid trehalase required for utilization of extracellular trehalose; involved in intracellular trehalose degradation during growth recovery after saline stress" /db_xref="GeneID:856137" /db_xref="SGD:S000006230" ORIGIN 1 mkrirslwfn aeasysnlnn spslrnknst gnnsrsknyr sfsrfdlins illlmmlfll 61 aifvtalylt kssrltysha sraalfnplg vispslgnht lnydpeares skklyellsd 121 fntayydden milgsnlfsk ntysrqpyva ngyigsripn igfgyaldtl nfytdapgal 181 nngwplrnhr fagafvsdfy clqpklnstn fpelddvgys tvissipqwt nlqfslvnds 241 kwfnpqnvtl ddvtnysqnl smkdgivtte ldwlnsqihv kseiwahrhi hplgvvslei 301 slntdhlpsd fdsldvniwd ildfntshrt vlhstgtdek nnavfmivqp dnvpssncai 361 ystctvkyen stnpinsses feekdvssni ynviltedqp kiivhkyvgi mstefnknke 421 qqdntnigla kmialnskgn yekllsshkr awydlyndaf ieipsdslle mtarsslfhl 481 lantrdynvs sdrglpvgvs glssdsyggm vfwdadiwme pallpffpnv aqnmnnyrna 541 thsqaklnae kygypgaiyp wtsgkyanct stgpcvdyey hinvdvamas fsiylngheg 601 iddeylrytt wpiiknaaqf ftayvkynss lglyetynlt dpdefanhin ngaftnagik 661 tllkwatdig nhlgevvdpk wseiskdiyi prsssnitle ysgmnssvei kqadvtlmvy 721 plgyindesi lnnaikdlyy yserqsasgp amtypvfvaa aagllnhgss sqsylyksvl 781 pylrapfaqf seqsddnflt ngltqpafpf ltanggflqs ilfgltgiry syevdpdtkk 841 inrllrfnpi elpllpggia irnfkymnqv ldiiiddhng tivhksgdvp ihikipnrsl 901 ihdqdinfyn gsenerkpnl errdvdrvgd pmrmdrygty yllkpkqelt vqlfkpglna 961 rnniaenkqi tnltagvpgd vafsaldgnn ythwqpldki hrakllidlg eynekeitkg 1021 milwgqrpak nisisilphs ekvenlfanv teimqnsgnd qllnetigql ldnagipven 1081 vidfdgieqe ddeslddvqa llhwkkedla klieqiprln flkrkfvkil dnvpvspsep 1141 yyeasrnqsl ieilpsnrtt ftidydklqv gdkgntdwrk tryivvavqg vyddydddnk 1201 gatikeivln d // LOCUS NP_015352 277 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR027C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015352 VERSION NP_015352.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184124.1 REFERENCE 1 (residues 1 to 277) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 277) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 277) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 277) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11453. Method: conceptual translation. FEATURES Location/Qualifiers source 1..277 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..277 /product="uncharacterized protein" /calculated_mol_wt="30469" CDS 1..277 /locus_tag="YPR027C" /coded_by="NM_001184124.1:1..834" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and seamless-GFP fusion proteins localize to the endoplasmic reticulum, while the mCherry fusion protein localizes to the vacuole" /db_xref="GeneID:856138" /db_xref="SGD:S000006231" ORIGIN 1 mvgiyrilas fvpllgllfa fhdddmidtv tiiktvyetv tststapapa atksvsekkl 61 ddtkltlqvi qtmvscfsvg enpanmiscg lgvvilmfsl iielinklen dginepqrly 121 dlikpkyvel psnyvnekik ttfepldlyl gvnmntsgse lnqnclilkl gektalpfpg 181 laqqicytkg asneftnykl sdiqgnlnen sqgiangvfq kisnirkisg nfksqlyqis 241 ekitdenwdg savgftahgr ekgpnksqis vsfyrdn // LOCUS NP_015353 180 aa linear PLN 30-JUN-2025 DEFINITION Yop1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015353 VERSION NP_015353.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184125.1 REFERENCE 1 (residues 1 to 180) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 180) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 180) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 180) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 180) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11454. Method: conceptual translation. FEATURES Location/Qualifiers source 1..180 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..180 /product="Yop1p" /calculated_mol_wt="20139" Region 1..180 /region_name="YOP1" /note="Protein involved in membrane traffic [Intracellular trafficking and secretion]; COG5052" /db_xref="CDD:227385" CDS 1..180 /gene="YOP1" /locus_tag="YPR028W" /gene_synonym="YIP2" /coded_by="NM_001184125.1:1..543" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:16469703|PMID:22842922|PMID:26928762|PMID:27831485]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:11278413]" /experiment="EXISTENCE:direct assay:GO:0071782 endoplasmic reticulum tubular network [PMID:16469703]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0007029 endoplasmic reticulum organization [PMID:19665976]" /experiment="EXISTENCE:genetic interaction:GO:0032581 ER-dependent peroxisome organization [PMID:27129769]" /experiment="EXISTENCE:genetic interaction:GO:0034976 response to endoplasmic reticulum stress [PMID:27117666]" /experiment="EXISTENCE:genetic interaction:GO:0048309 endoplasmic reticulum inheritance [PMID:27117666]" /experiment="EXISTENCE:genetic interaction:GO:0051292 nuclear pore complex assembly [PMID:19273614]" /experiment="EXISTENCE:genetic interaction:GO:0071786 endoplasmic reticulum tubular network organization [PMID:18309084|PMID:16469703|PMID:18442980]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:11278413|PMID:12427979]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:11278413]" /note="Reticulon-interacting protein; ER integral membrane protein involved in the generation of tubular ER morphology; promotes membrane curvature; forms tubules in vitro; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; interacts with Yip1p to mediate membrane traffic and with Sey1p to maintain ER morphology; facilitates lipid exchange between the ER and mitochondria; forms ER foci upon DNA replication stress" /db_xref="GeneID:856140" /db_xref="SGD:S000006232" ORIGIN 1 mseyassihs qmkqfdtkys gnrilqqlen ktnlpksylv aglgfaylll ifinvggvge 61 ilsnfagfvl paylslvalk tptstddtql ltywivfsfl sviefwskai lylipfywfl 121 ktvfliyial pqtggarmiy qkivapltdr yilrdvskte kdeirasvne askatgasvh // LOCUS NP_015354 832 aa linear PLN 30-JUN-2025 DEFINITION AP-1 complex subunit gamma [Saccharomyces cerevisiae S288C]. ACCESSION NP_015354 VERSION NP_015354.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184126.1 REFERENCE 1 (residues 1 to 832) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 832) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 832) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 832) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 832) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11455. Method: conceptual translation. FEATURES Location/Qualifiers source 1..832 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..832 /product="AP-1 complex subunit gamma" /calculated_mol_wt="93493" Region 21..617 /region_name="Adaptin_N" /note="Adaptin N terminal region; pfam01602" /db_xref="CDD:396262" Region 727..828 /region_name="Alpha_adaptinC2" /note="Adaptin C-terminal domain; smart00809" /db_xref="CDD:197886" CDS 1..832 /gene="APL4" /locus_tag="YPR029C" /coded_by="NM_001184126.1:1..2499" /experiment="EXISTENCE:direct assay:GO:0030121 AP-1 adaptor complex [PMID:10564262]" /experiment="EXISTENCE:direct assay:GO:0030276 clathrin binding [PMID:11489214]" /experiment="EXISTENCE:mutant phenotype:GO:0006896 Golgi to vacuole transport [PMID:17003107]" /note="Gamma-adaptin; large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport" /db_xref="GeneID:856141" /db_xref="SGD:S000006233" ORIGIN 1 mgsslrsfik dvrgaktlad eraiitkqsa kirtklrddh lphekrrvni qkllylyilg 61 ekthfgqves inliasddfv dkrlgylaat llldesedll tlltnmlnnd lhhpnkyavs 121 laltslgfls spelardlyp dveniiknsr dpfllkkalq caaklifkdv slleifnied 181 itkilsshsi cthgvllgvt kiiqsillig lnrkkdeded edgidysndi lsplslllrd 241 ffirlenmns kniepgydvq gicdpflqce iiytlklyfq vgellnsnnv ldykdnfcdl 301 ltriatntds tknsgqaily etvktifsld lnqplrvlgi nilakflagk dnntkyvsln 361 tllkvvpqep tavqrhrkfi shclqdtdvs irmralelsf ailddsnlve lvnelmkfla 421 kqdedskdli iytidhlidt fdtrvvkdes wkldvffnil klvgsfinye kindiliiin 481 ntsqlsdkse flrkmltisl ngtsaeisee nigwqlvliw cigeygdlvl negnkngadi 541 inessitdyl ltlqelytat nlkiinyilt aalklsvrfh daknieklrq lilsytdstd 601 lslqmksnqy eiffnqsisv kkiiletmpk fekiteeqdn gkalsknlis nepvdllsdl 661 lgedskaesk astgdnvkpi dileeifgek ndiaqvpkna nkeesinhss aveansgvtl 721 pldankiyds sslnvyasll sansglahld lyfqakslis dlktfcavpk aqkltlgqly 781 psstinasqi ckqslkisgs gklklrvkld fhlngsssit neqfdhkfde tl // LOCUS NP_015355 1121 aa linear PLN 30-JUN-2025 DEFINITION Csr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015355 VERSION NP_015355.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184127.1 REFERENCE 1 (residues 1 to 1121) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1121) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1121) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1121) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1121) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11456. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1121 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1121 /product="Csr2p" /calculated_mol_wt="124718" Region 638..>737 /region_name="Arrestin_C" /note="Arrestin (or S-antigen), C-terminal domain; smart01017" /db_xref="CDD:214976" Region <828..926 /region_name="Arrestin_C" /note="Arrestin (or S-antigen), C-terminal domain; smart01017" /db_xref="CDD:214976" CDS 1..1121 /gene="CSR2" /locus_tag="YPR030W" /gene_synonym="ART8; MRG19" /coded_by="NM_001184127.1:1..3366" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12444972]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:12444972]" /experiment="EXISTENCE:genetic interaction:GO:0031505 fungal-type cell wall organization [PMID:10679005]" /experiment="EXISTENCE:mutant phenotype:GO:0006357 regulation of transcription by RNA polymerase II [PMID:12444972]" /experiment="EXISTENCE:physical interaction:GO:0031625 ubiquitin protein ligase binding [PMID:18976803]" /note="Nuclear ubiquitin protein ligase binding protein; may regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p; CSR2 has a paralog, ECM21, that arose from the whole genome duplication" /db_xref="GeneID:856142" /db_xref="SGD:S000006234" ORIGIN 1 mqstvpiaia sngnkrdvvq nvsagdegdi lqrlarnrem istslspqks sgfsgrrrss 61 svrdalssff gtgnsptssm ddysnlmnrn ystastamcr gnsfpsdvgt kaynitgsyq 121 pdrhrnsvpy ttidqlhtrq dtglrresdp vaakqissnn divrsfithh asnstmfinr 181 vlsdyladrg fikqtplynk ksvleisiat saesvflptt ksdeteylsl ihgslnqart 241 qpvgstntae sdflpscptm dtlnenndls lfplhtqrts psntartgna mdtsnsdras 301 pasnnnttda dsfvasgnnn pmnnnnspar nrhpnshsrs lpnawnsqmp sfsfalifsl 361 nksttlsdik veltsnvrvv wfnglpptkn vneecynigs ldwtlnadnf nlfipqgaks 421 pldivenhsn nrklkvlqkl smrkrrsfsn kavlreniln nlnasnstnk lnagvyvfti 481 pivlasripe slyypsarvs yslrlatklk dehtqlvasr prsssisspq klrsyscsds 541 yeysqiddti egetynndkn stgkiafpss wlksakgrlk rnnsngrsdn ngasssglam 601 qhdsedtinl qyplnlvrtp peisvttank plyinkvwen clsyeisfaq kyvplngeip 661 itikvaplvk slsvkrirvs crekisyrsk dyqydfdqld plasdpcnpy hmrylvrkkk 721 drslplfeva skctsgpsir eevvtntvdd nllaytsske nnkdipfses ftvktklkfp 781 kycevdatka aslppygidl fdpikdptqs entsnngnvl gflvgrpnra sktvhkipqd 841 knhnevndtn gnsntslqts snvpiqhytr lnkprrglyl dsmhfkniqc shkleivlrv 901 sktdsgsski irhyevivdt piylisdlcn tsnidlptyd mattesskvl pptfeeatsv 961 sasprssvsy ypddismqql nlsrstslan gylstlhpkt tavsdssnga pirdqqeqqa 1021 rplrtedyal qmgnennays nmdgllsqdi feqetaatlf krdivtmnfn nniftprysp 1081 rtftntdyny ndndnndndt egpgpiihpg pepprydeis s // LOCUS NP_015356 748 aa linear PLN 30-JUN-2025 DEFINITION Nto1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015356 VERSION NP_015356.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184128.1 REFERENCE 1 (residues 1 to 748) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 748) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 748) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 748) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 748) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11457. Method: conceptual translation. FEATURES Location/Qualifiers source 1..748 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..748 /product="Nto1p" /calculated_mol_wt="85899" Region 18..748 /region_name="COG5141" /note="PHD zinc finger-containing protein [General function prediction only]" /db_xref="CDD:227470" CDS 1..748 /gene="NTO1" /locus_tag="YPR031W" /coded_by="NM_001184128.1:1..2247" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0033100 NuA3 histone acetyltransferase complex [PMID:17157260]" /experiment="EXISTENCE:direct assay:GO:0140003 histone H3K36me3 reader activity [PMID:17142463]" /experiment="EXISTENCE:direct assay:GO:1990467 NuA3a histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:direct assay:GO:1990468 NuA3b histone acetyltransferase complex [PMID:25104842]" /experiment="EXISTENCE:physical interaction:GO:0006338 chromatin remodeling [PMID:17157260]" /note="Subunit of the NuA3 histone acetyltransferase complex; this complex acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3" /db_xref="GeneID:856143" /db_xref="SGD:S000006235" ORIGIN 1 mnrgslddgp klreekhfqd fypdlnadtl lpfivplvet kdnstdtdsd disnrnnrei 61 gsvksvqtke lifkgrvtte plvlkkneve fqkckittne lkgkknpycv rfnesfisry 121 yhinkvrnrk sykqqqkefd gveapyftkf sskeapniti ststksaiqk fasispnlvn 181 fkpqydmdeq delylhylnk ryfkdqmshe ifeilmttle tewfhiekhi pstnsliarh 241 nilrdcknye lygsddgtgl smdqacavcl gtdsdnlnti vfcdgcdiav hqecygiifi 301 pegkwlcrrc misknnfatc lmcpshtgaf kqtdtgswvh nicalwlpel yfsnlhymep 361 iegvqnvsvs rwklncyick kkmgaciqcf qrncftayhv tcarraglym skgkctiqel 421 asnqfsqkys vesfchkhap rgwqtsiegi nkarkyfsll stlqtetpqh neandrtnsk 481 fnktiwktpn qtpvaphvfa eilqkvvdff glanppagaf dickywsmkr eltggtplta 541 cfennslgsl teeqvqtrid fandqledly rlkelttlvk krtqasnsls rsrkkvfdiv 601 kspqkyllki nvldifikse qfkalerlvt epkllvilek ckhcdfdtvq ifkeeimhff 661 evletlpgas rilqtvsska keqvtnligl iehvdikkll srdfiinddk ieerpwsgpv 721 imeeeglsda eelsagehrm lklilnsg // LOCUS NP_015357 1033 aa linear PLN 30-JUN-2025 DEFINITION Rab GTPase-binding protein SRO7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015357 VERSION NP_015357.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184129.1 REFERENCE 1 (residues 1 to 1033) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1033) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1033) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1033) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1033) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1033) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1033) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11458. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1033 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1033 /product="Rab GTPase-binding protein SRO7" /calculated_mol_wt="114382" Region 548..943 /region_name="Lgl_C" /note="Lethal giant larvae(Lgl) like, C-terminal; pfam08596" /db_xref="CDD:400768" CDS 1..1033 /gene="SRO7" /locus_tag="YPR032W" /gene_synonym="SNI1; SOP1" /coded_by="NM_001184129.1:1..3102" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:10402465|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10402465]" /experiment="EXISTENCE:direct assay:GO:0031267 small GTPase binding [PMID:16390997]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:22832273]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:10402465]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:10402465]" /experiment="EXISTENCE:physical interaction:GO:0000149 SNARE binding [PMID:15964280]" /experiment="EXISTENCE:physical interaction:GO:0007264 small GTPase-mediated signal transduction [PMID:16390997]" /experiment="EXISTENCE:physical interaction:GO:0030010 establishment of cell polarity [PMID:15964280]" /note="Effector of Rab GTPase Sec4p; forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; regulates cell proliferation and colony development via the Rho1-Tor1 pathway; homolog of Drosophila lgl tumor suppressor; SRO7 has a paralog, SRO77, that arose from the whole genome duplication" /db_xref="GeneID:856144" /db_xref="SGD:S000006236" ORIGIN 1 mfgskrlknv keafkslkgq nsetpiensk asfksknskt stiskdakss sslkipissn 61 nknkifslae tnkygmsskp iaaafdftqn llaiatvtge vhiygqqqve vvikledrsa 121 ikemrfvkgi ylvvinakdt vyvlslysqk vlttvfvpgk itsidtdasl dwmliglqng 181 smivydidrd qlssfkldnl qkssffpaar lspivsiqwn prdigtvlis yeyvtltysl 241 veneikqsfi yelppfapgg dfsektnekr tpkviqslyh pnslhiitih ednslvfwda 301 nsghmimart vfeteinvpq pdyirdsstn aakiskvywm cennpeytsl lishksisrg 361 dnqsltmidl gytprysits yegmknyyan pkqmkifplp tnvpivnilp iprqspyfag 421 chnpglilli lgngeietml ypsgiftdka slfpqnlswl rplattsmaa svpnklwlga 481 lsaaqnkdyl lkggvrtkrq klpaeygtaf itghsngsvr iydashgdiq dnasfevnls 541 rtlnkakela vdkisfaaet lelavsietg dvvlfkyevn qfysvenrpe sgdlemnfrr 601 fslnntngvl vdvrdraptg vrqgfmpsta vhankgktsa innsnigfvg iayaagslml 661 idrrgpaiiy menireisga qsacvtcief vimeygddgy ssilmvcgtd mgevitykil 721 pasggkfdvq lmditnvtsk gpihkidafs ketkssclat ipkmqnlskg lcipgivlit 781 gfddirlitl gksksthkgf kyplaatgls yistveknnd rknltviitl einghlrvft 841 ipdfkeqmse hipfpiaaky itessvlrng diairvsefq aslfstvkeq dtlapvsdtl 901 yingiripyr pqvnslqwar gtvyctpaql nellggvnrp askykesiia egsfserssd 961 dnnanhpehq ytkptrkgrn ssygvlrnvs ravetrwdav edrfndyata mgetmneave 1021 qtgkdvmkga lgf // LOCUS NP_015358 546 aa linear PLN 30-JUN-2025 DEFINITION histidine--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015358 VERSION NP_015358.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184130.1 REFERENCE 1 (residues 1 to 546) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 546) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 546) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 546) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 546) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11459. Method: conceptual translation. FEATURES Location/Qualifiers source 1..546 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..546 /product="histidine--tRNA ligase" /EC_number="6.1.1.21" /calculated_mol_wt="59822" Region <56..503 /region_name="PLN02972" /note="Histidyl-tRNA synthetase" /db_xref="CDD:215525" CDS 1..546 /gene="HTS1" /locus_tag="YPR033C" /gene_synonym="TS4572; TSM4572" /coded_by="NM_001184130.1:1..1641" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0004812 aminoacyl-tRNA ligase activity [PMID:16741232]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0006427 histidyl-tRNA aminoacylation [PMID:16741232]" /experiment="EXISTENCE:direct assay:GO:1990825 sequence-specific mRNA binding [PMID:34039240]" /experiment="EXISTENCE:genetic interaction:GO:0032543 mitochondrial translation [PMID:16777356]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:3521891]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:3521891]" /experiment="EXISTENCE:mutant phenotype:GO:0006427 histidyl-tRNA aminoacylation [PMID:1459448]" /note="Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome" /db_xref="GeneID:856145" /db_xref="SGD:S000006237" ORIGIN 1 mlsrslnkvv tsiksssiir mssataaats aptanaanal kaskapkkgk lqvslktpkg 61 tkdwadsdmv ireaifstls glfkkhggvt idtpvfelre ilagkygeds kliynledqg 121 gelcslrydl tvpfaryvam nniqsikryh iakvyrrdqp amtkgrmref yqcdfdvagt 181 fesmvpdsec lsilveglts lgikdfkikl nhrkildgif qiagvkdedv rkissavdkl 241 dkspweavkk emteekgqse etadkigeyv klngslkeih avlsadanit snekakqgld 301 diatlmkyte afdidsfisf dlslargldy ytgliyevvt sasappenas elkkkaksae 361 dasefvgvgs iaaggrydnl vnmfseasgk kstqipcvgi sfgverifsl ikqrinsstt 421 ikptatqvfv mafgggkdwt gylpermkvt kqlwdagiea eyvykakanp rkqfdaaeka 481 gchiavilgk eeylegklrv krlgqefadd dgelvsaadi vpivqeklsq ihedglnevt 541 rlikgl // LOCUS NP_015359 477 aa linear PLN 30-JUN-2025 DEFINITION Arp7p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015359 VERSION NP_015359.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184131.1 REFERENCE 1 (residues 1 to 477) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 477) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 477) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 477) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 477) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11460. Method: conceptual translation. FEATURES Location/Qualifiers source 1..477 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..477 /product="Arp7p" /calculated_mol_wt="53679" Region 3..466 /region_name="ASKHA_NBD_ScArp7-like" /note="nucleotide-binding domain (NBD) of Saccharomyces cerevisiae actin-related protein7 (Arp7) and similar proteins; cd10212" /db_xref="CDD:466818" CDS 1..477 /gene="ARP7" /locus_tag="YPR034W" /gene_synonym="RSC11; SWP61" /coded_by="NM_001184131.1:1..1434" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:11011149]" /experiment="EXISTENCE:direct assay:GO:0006337 nucleosome disassembly [PMID:16492771]" /experiment="EXISTENCE:direct assay:GO:0006338 chromatin remodeling [PMID:12183366]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:17081996]" /experiment="EXISTENCE:direct assay:GO:0016514 SWI/SNF complex [PMID:8127913|PMID:9726966|PMID:18644858]" /experiment="EXISTENCE:direct assay:GO:0016586 RSC-type complex [PMID:10619019|PMID:12183366]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9726966]" /note="Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation" /db_xref="GeneID:856146" /db_xref="SGD:S000006238" ORIGIN 1 mtlnrkcvvi hngshrtvag fsnvelpqci ipssyikrtd eggeaefifg tynmidaaae 61 krngdevytl vdsqglpynw dalemqwryl ydtqlkvspe elplvitmpa tngkpdmail 121 eryyelafdk lnvpvfqivi eplaialsmg kssafvidig asgcnvtpii dgivvknavv 181 rskfggdfld fqvherlapl ikeendmenm adeqkrstdv wyeastwiqq fkstmlqvse 241 kdlfeleryy keqadiyakq qeqlkqmdqq lqytaltgsp nnplvqkknf lfkplnktlt 301 ldlkecyqfa eylfkpqlis dkfspedglg plmaksvkka gasinsmkan tstnpnglgt 361 shintnvgdn nstasssnis peqvyslllt nviitgstsl iegmeqriik elsirfpqyk 421 lttfanqvmm drkiqgwlga ltmanlpsws lgkwyskedy etlkrdrkqs qatnatn // LOCUS NP_015360 370 aa linear PLN 30-JUN-2025 DEFINITION glutamate--ammonia ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015360 VERSION NP_015360.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184132.2 REFERENCE 1 (residues 1 to 370) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 370) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 370) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 370) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 370) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11461. On Apr 26, 2011 this sequence version replaced NP_015360.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..370 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..370 /product="glutamate--ammonia ligase" /EC_number="6.3.1.2" /calculated_mol_wt="41635" Region 19..352 /region_name="PLN02284" /note="glutamine synthetase" /db_xref="CDD:177922" CDS 1..370 /gene="GLN1" /locus_tag="YPR035W" /coded_by="NM_001184132.2:1..1113" /experiment="EXISTENCE:direct assay:GO:0004356 glutamine synthetase activity [PMID:4156034]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006542 glutamine biosynthetic process [PMID:6129248]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:25817432]" /experiment="EXISTENCE:mutant phenotype:GO:0004356 glutamine synthetase activity [PMID:1347768]" /note="Glutamine synthetase (GS); synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation; forms filaments of back-to-back stacks of cylindrical homo-decamers at low pH, leading to enzymatic inactivation and storage during states of advanced cellular starvation; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:856147" /db_xref="SGD:S000006239" ORIGIN 1 maeasiektq ilqkyleldq rgriiaeyvw idgtgnlrsk grtlkkrits idqlpewnfd 61 gsstnqapgh dsdiylkpva yypdpfrrgd nivvlaacyn ndgtpnkfnh rheaaklfaa 121 hkdeeiwfgl eqeytlfdmy ddvygwpkgg ypapqgpyyc gvgagkvyar dmieahyrac 181 lyagleisgi naevmpsqwe fqvgpctgid mgdqlwmary flhrvaeefg ikisfhpkpl 241 kgdwngagch tnvstkemrq pggmkyieqa ieklskrhae hiklygsdnd mrltgrheta 301 smtafssgva nrgssiripr svakegygyf edrrpasnid pylvtgimce tvcgaidnad 361 mtkeferess // LOCUS NP_015361 478 aa linear PLN 30-JUN-2025 DEFINITION H(+)-transporting V1 sector ATPase subunit H [Saccharomyces cerevisiae S288C]. ACCESSION NP_015361 VERSION NP_015361.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184133.1 REFERENCE 1 (residues 1 to 478) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 478) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 478) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 478) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 478) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11462. Method: conceptual translation. FEATURES Location/Qualifiers source 1..478 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..478 /product="H(+)-transporting V1 sector ATPase subunit H" /calculated_mol_wt="54285" Region 1..478 /region_name="VMA13" /note="Vacuolar H+-ATPase V1 sector, subunit H [Energy production and conversion]; COG5231" /db_xref="CDD:227556" Site order(90..105,107,111..119,122..129,133..154,157..166, 169..174,182..207,211..218,239..256,261..278,285..298, 307..316,317..330) /site_type="other" /note="armadillo-like superhelical repeats" /db_xref="CDD:238159" Site order(104,144,185,189) /site_type="active" /note="putative peptide binding site [active]" /db_xref="CDD:238159" Site order(272,313..315,319,353,357..358,362,367..368,370,375) /site_type="active" /note="putative peptide binding site [active]" /db_xref="CDD:238159" CDS 1..478 /gene="VMA13" /locus_tag="YPR036W" /gene_synonym="CLS11" /coded_by="NM_001184133.1:1..1437" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762|PMID:23708375]" /experiment="EXISTENCE:mutant phenotype:GO:0007035 vacuolar acidification [PMID:18708638]" /note="Subunit H of the V1 peripheral membrane domain of V-ATPase; part of the electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase; the V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase) has eight subunits" /db_xref="GeneID:856148" /db_xref="SGD:S000006240" ORIGIN 1 mgatkilmds thfneirsii rsrsvawdal arseelseid astakalesi lvkknigdgl 61 sssnnahsgf kvngktlipl ihllstsdne dckksvqnli aellssdkyg ddtvkffqed 121 pkqleqlfdv slkgdfqtvl isgfnvvsll vqnglhnvkl vekllknnnl inilqnieqm 181 dtcyvcirll qelavipeyr dviwlhekkf mptlfkilqr atdsqlatri vatnsnhlgi 241 qlqyhsllli wlltfnpvfa nelvqkylsd fldllklvki tikekvsrlc isiilqccst 301 rvkqhkkvik qllllgnalp tvqslserky sdeelrqdis nlkeileney qeltsfdeyv 361 aeldskllcw spphvdngfw sdnidefkkd nykifrqlie llqakvrngd vnakqekiii 421 qvalndithv vellpesidv ldktggkadi mellnhsdsr vkyealkatq aiigytfk // LOCUS NP_690847 67 aa linear PLN 30-JUN-2025 DEFINITION Spo24p [Saccharomyces cerevisiae S288C]. ACCESSION NP_690847 VERSION NP_690847.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184516.1 REFERENCE 1 (residues 1 to 67) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 67) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 67) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 67) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 67) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11463. Method: conceptual translation. FEATURES Location/Qualifiers source 1..67 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..67 /product="Spo24p" /calculated_mol_wt="6924" CDS 1..67 /gene="SPO24" /locus_tag="YPR036W-A" /coded_by="NM_001184516.1:1..204" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:25127041]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:25127041]" /note="Small (67 amino acids) protein involved in sporulation; localizes to the prospore membrane; phosphorylated during meiosis; a longer, 5'-extended mRNA is also transcribed beginning in mid-meiosis, regulated by two MSEs (middle sporulation elements), and includes an uORF of 15 codons in its 5'-UTR; evidence transcription is regulated by Pdr1p" /db_xref="GeneID:856149" /db_xref="SGD:S000028425" ORIGIN 1 mvafleltsd vsqpfvipsl spvsqpssrk nsdanvddln laianaalld asassrshsr 61 knslsll // LOCUS NP_015362 196 aa linear PLN 30-JUN-2025 DEFINITION flavin-linked sulfhydryl oxidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015362 VERSION NP_015362.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184134.1 REFERENCE 1 (residues 1 to 196) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 196) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 196) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 196) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 196) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11464. Method: conceptual translation. FEATURES Location/Qualifiers source 1..196 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..196 /product="flavin-linked sulfhydryl oxidase" /EC_number="1.8.3.2" /calculated_mol_wt="22010" Region 1..180 /region_name="ERV1" /note="Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins [Posttranslational modification, protein turnover, chaperones]; COG5054" /db_xref="CDD:227387" CDS 1..196 /gene="ERV2" /locus_tag="YPR037C" /coded_by="NM_001184134.1:1..591" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:11584268]" /experiment="EXISTENCE:direct assay:GO:0016971 flavin-dependent sulfhydryl oxidase activity [PMID:11584268]" /experiment="EXISTENCE:direct assay:GO:0016972 thiol oxidase activity [PMID:11313344]" /experiment="EXISTENCE:direct assay:GO:0060904 regulation of protein folding in endoplasmic reticulum [PMID:11584268]" /note="Flavin-linked sulfhydryl oxidase localized to the ER lumen; involved in disulfide bond formation within the endoplasmic reticulum (ER)" /db_xref="GeneID:856152" /db_xref="SGD:S000006241" ORIGIN 1 mkqivkrsha irivaalgii glwmffssne lsiatpglik aksgidevqg aaaekndarl 61 keiekqtimp lmgddkvkke vgraswkyfh tllarfpdep tpeereklht figlyaelyp 121 cgecsyhfvk liekypvqts srtaaamwgc hihnkvneyl kkdiydcati ledydcgcsd 181 sdgkrvslek eakqhg // LOCUS NP_001381971 119 aa linear PLN 30-JUN-2025 DEFINITION Irc16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_001381971 VERSION NP_001381971.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001395041.1 REFERENCE 1 (residues 1 to 119) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 119) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 119) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 119) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 119) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAD54812. Method: conceptual translation. FEATURES Location/Qualifiers source 1..119 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..119 /product="Irc16p" /calculated_mol_wt="13320" CDS 1..119 /gene="IRC16" /locus_tag="YPR038W" /coded_by="NM_001395041.1:1..360" /experiment="EXISTENCE:mutant phenotype:GO:0006312 mitotic recombination [PMID:18085829]" /note="hypothetical protein; partially overlaps verified gene ERV2/YPR037C but doesn't share phenotypes; also overlaps dubious ORF YPR039W; null mutant displays increased levels of spontaneous Rad52p foci, increased biofilm information, different altered sensitivities to various chemcicals" /db_xref="GeneID:856150" /db_xref="SGD:S000006242" ORIGIN 1 mvcfsisfnr asffsaaapc tssipdfali rpgvamdssl deknihrpmi pnaatilmaw 61 lllticfips flaqsvqtfl ftnhqpsrll vfithvyclm ikpfvlyfwf lfplrlpgg // LOCUS NP_015365 356 aa linear PLN 30-JUN-2025 DEFINITION Tip41p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015365 VERSION NP_015365.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184137.1 REFERENCE 1 (residues 1 to 356) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 356) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 356) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 356) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 356) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11465. Method: conceptual translation. FEATURES Location/Qualifiers source 1..356 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..356 /product="Tip41p" /calculated_mol_wt="40889" Region 130..312 /region_name="TIP41" /note="TIP41-like family; pfam04176" /db_xref="CDD:461208" CDS 1..356 /gene="TIP41" /locus_tag="YPR040W" /coded_by="NM_001184137.1:1..1071" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:1904262 negative regulation of TORC1 signaling [PMID:11741537]" /note="Tap42p-interacting protein; negative regulator of the TORC1 signaling pathway that activates the type 2A-related phosphatase Sit4p by binding and antagonizing Tap42p, a SIT4 inhibitor; proposed to be part of a feedback loop to amplify Sit4p activity when TORC1 is inactivated; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856153" /db_xref="SGD:S000006244" ORIGIN 1 mskrntpplr ssgintiqin aaremhaqtv rarrmpmpts gittpsvqpt aapatpprhi 61 cnnpnnpqcl hcgsviipsp ratlplednp sisindwtis srkkpilnsq eldiwenekl 121 kgltlpemif gnnyiriens kqhwsiefna ldalkevqlq dsgirvaysn dwinskkrqn 181 stngaqrftn dvnddslnii hkydwtyttr ykgtesspes kfrldndqkl pldklavhdk 241 ilfyddmilf edeladngis ilnvkirvmn erllllsrff lrvddvlvrv ydtriyvefd 301 envvireske fegkyqdvla khrlsqshdp kaalrdsnwv aqntpmikrq ceiiqf // LOCUS NP_015366 405 aa linear PLN 30-JUN-2025 DEFINITION translation initiation factor eIF5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015366 VERSION NP_015366.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184138.1 REFERENCE 1 (residues 1 to 405) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 405) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 405) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 405) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 405) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11466. Method: conceptual translation. FEATURES Location/Qualifiers source 1..405 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..405 /product="translation initiation factor eIF5" /calculated_mol_wt="45130" Region 8..127 /region_name="eIF-5_eIF-2B" /note="Domain found in IF2B/IF5; pfam01873" /db_xref="CDD:426485" Region 242..392 /region_name="W2_eIF5" /note="C-terminal W2 domain of eukaryotic translation initiation factor 5; cd11561" /db_xref="CDD:211399" CDS 1..405 /gene="TIF5" /locus_tag="YPR041W" /gene_synonym="SUI5" /coded_by="NM_001184138.1:1..1218" /experiment="EXISTENCE:direct assay:GO:0001732 formation of cytoplasmic translation initiation complex [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0003743 translation initiation factor activity [PMID:12008673]" /experiment="EXISTENCE:direct assay:GO:0005092 GDP-dissociation inhibitor activity [PMID:20485439]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:9308967]" /experiment="EXISTENCE:direct assay:GO:0006446 regulation of translational initiation [PMID:22851688]" /experiment="EXISTENCE:direct assay:GO:0031369 translation initiation factor binding [PMID:15145951|PMID:16380131|PMID:22683627]" /experiment="EXISTENCE:direct assay:GO:0033290 eukaryotic 48S preinitiation complex [PMID:17242201]" /experiment="EXISTENCE:direct assay:GO:0043614 multi-eIF complex [PMID:11018020|PMID:15838098]" /experiment="EXISTENCE:genetic interaction:GO:0045947 negative regulation of translational initiation [PMID:20485439]" /experiment="EXISTENCE:mutant phenotype:GO:0005092 GDP-dissociation inhibitor activity [PMID:20485439]" /experiment="EXISTENCE:mutant phenotype:GO:0005096 GTPase activator activity [PMID:9308967]" /experiment="EXISTENCE:mutant phenotype:GO:0006446 regulation of translational initiation [PMID:22851688|PMID:11331597]" /experiment="EXISTENCE:mutant phenotype:GO:0042256 cytosolic ribosome assembly [PMID:11331597]" /experiment="EXISTENCE:mutant phenotype:GO:0045947 negative regulation of translational initiation [PMID:20485439]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:9395514|PMID:22683627]" /experiment="EXISTENCE:physical interaction:GO:0031369 translation initiation factor binding [PMID:22851688|PMID:15145951]" /note="Translation initiation factor eIF5; functions as both a GTPase-activating protein (GAP) that stimulates the hydrolysis of GTP bound to eIF-2, as part of the 43S preinitiation complex, and as a GDP dissociation inhibitor (GDI) to prevent recycling of eIF2; human ortholog eIF5 complements the yeast null mutant" /db_xref="GeneID:856154" /db_xref="SGD:S000006245" ORIGIN 1 msinicrdnh dpfyrykmpp iqakvegrgn giktavlnva dishalnrpa pyivkyfgfe 61 lgaqtsisvd kdrylvngvh epaklqdvld gfinkfvlcg scknpeteii itkdndlvrd 121 ckacgkrtpm dlrhklssfi lknppdsvsg skkkkkaata sanvrgggls isdiaqgksq 181 napsdgtgss tpqhhdeded elsrqikaaa stledievkd dewavdmsee airarakele 241 vnseltqlde ygewileqag edkenlpsdv elykkaaeld vlndpkigcv laqclfdedi 301 vneiaehnaf ftkilvtpey eknfmggier flglehkdli pllpkilvql ynndiiseee 361 imrfgtkssk kfvpkevskk vrraakpfit wletaesddd eedde // LOCUS NP_015367 1075 aa linear PLN 30-JUN-2025 DEFINITION Puf2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015367 VERSION NP_015367.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184139.1 REFERENCE 1 (residues 1 to 1075) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1075) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1075) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1075) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1075) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1075) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1075) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11467. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1075 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1075 /product="Puf2p" /calculated_mol_wt="119378" Region 70..884 /region_name="COG5099" /note="RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]" /db_xref="CDD:227430" CDS 1..1075 /gene="PUF2" /locus_tag="YPR042C" /coded_by="NM_001184139.1:1..3228" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640|PMID:21685478|PMID:15024427]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [PMID:11101532]" /note="PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication" /db_xref="GeneID:856155" /db_xref="SGD:S000006246" ORIGIN 1 mdnkrlyngn lsnipevidp gitipiyeed irndtrmntn arsvrvsdkr grssstspqk 61 igsyrtragr fsdtltnllp sisaklhhsk kstpvvvvpp tsstpdslns ttyaprvssd 121 sftvatplsl qstttrtrtr nntvssqita ssslttdvgn atsaniwsan aesntssspl 181 fdyplatsyf epltrfkstd nytlpqtaql nsflekngnp niwssagnsn tdhlntpivn 241 rqrsqsqstt nrvytdapyy qqpaqnyqvq vpprvpksts ispvilddvd pasinwitan 301 qkvplvnqis allptntisi snvfplqptq qhqqnavnlt stslatlcsq ygkvlsartl 361 rglnmalvef stvesaical ealqgkelsk vgapstvsfa rvlpmyeqpl nvngfnntpk 421 qpllqeqlnh gvlnyqlqqs lqqpelqqqp tsfnqpnlty cnptqnlshl qlssnenepy 481 pfplpppsls dskkdilhti ssfkleydhl elnhllqnal knkgvsdtny fgplpehnsk 541 vpkrkdtfda pklrelrkqf dsnslstiem eqlaivmldq lpelssdylg ntviqklfen 601 ssniirdiml rkcnkyltsm gvhkngtwvc qkiikmantp rqinlvtsgv sdyctplfnd 661 qfgnyviqgi lkfgfpwnsf ifesvlshfw tivqnrygsr avracleads iitqcqllti 721 tsliivlspy latdtngtll itwlldtctl pnknlilcdk lvnknlvklc chklgsltvl 781 kilnlrggee ealsknkiih aifdgpissd silfqildeg nygptfiykv ltsrildnsv 841 rdeaitkirq lilnsninlq srqlleevgl ssagispkqs sknhrkqhpq gfhspgrarg 901 vsvssvrssn srhnsviqmn nagptpalnf npapmseins yfnnqqvvys gnqnqnqngn 961 sngldelnsq fdsfriangt nlslpivnlp nvsnnnnnyn nsgyssqmnp lsrsvshnnn 1021 nntnnynnnd ndnnnnnnnn nnnnnnnnnn nnnsnnsnnn nnndtslyry rsygy // LOCUS NP_015368 92 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein eL43 RPL43A [Saccharomyces cerevisiae S288C]. ACCESSION NP_015368 VERSION NP_015368.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184140.1 REFERENCE 1 (residues 1 to 92) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 92) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 92) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 92) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 92) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11468. Method: conceptual translation. FEATURES Location/Qualifiers source 1..92 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..92 /product="60S ribosomal protein eL43 RPL43A" /calculated_mol_wt="9960" Region 1..88 /region_name="PTZ00255" /note="60S ribosomal protein L37a; Provisional" /db_xref="CDD:240332" CDS 1..92 /gene="RPL43A" /locus_tag="YPR043W" /coded_by="NM_001184140.1:1..279" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /note="Ribosomal 60S subunit protein L43A; null mutation confers a dominant lethal phenotype; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43A has a paralog, RPL43B, that arose from the whole genome duplication" /db_xref="GeneID:856156" /db_xref="SGD:S000006247" ORIGIN 1 makrtkkvgi tgkygvrygs slrrqvkkle iqqharydcs fcgkktvkrg aagiwtcscc 61 kktvaggayt vstaaaatvr stirrlremv ea // LOCUS NP_015370 470 aa linear PLN 30-JUN-2025 DEFINITION Thp3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015370 VERSION NP_015370.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184142.1 REFERENCE 1 (residues 1 to 470) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 470) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 470) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 470) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11469. Method: conceptual translation. FEATURES Location/Qualifiers source 1..470 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..470 /product="Thp3p" /calculated_mol_wt="53588" Region 206..424 /region_name="SAC3_GANP" /note="SAC3/GANP family; cl24019" /db_xref="CDD:474128" CDS 1..470 /gene="THP3" /locus_tag="YPR045C" /coded_by="NM_001184142.1:1..1413" /experiment="EXISTENCE:direct assay:GO:0000791 euchromatin [PMID:21149575]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:19061648]" /note="Protein that may have a role in transcription elongation; forms a complex with Csn12p that is recruited to transcribed genes; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes" /db_xref="GeneID:856158" /db_xref="SGD:S000006249" ORIGIN 1 mqnpyghftn nttedreass qggpfgqsln rpldyagsfp sltynnnnfi anqqpslplp 61 eprlswnnvn qvsnplmvtp lpglqkrmnk nikkklprvs kkasalsngv sgnvmsnsni 121 vghgavgsas gwkvemggsd elerrkrrae rfsqgpsatt nsndnlnedf anlnaissks 181 hqydkkihvv grcqtleksy lrltsepnpd lirppnilqk mycllmdkyq sktatytylc 241 dqfksmrqdl rvqmiensft ikvyqthari alengdlgef nqcqnrimal fenptipkks 301 yseficysvl ysmltedyps ishlklklid dgsseilede hvkmifelsd mklvgnyhyf 361 mknylklhkf ekclinsfln leklifltii cksynqvnld fvksefnfns ieettnflne 421 qnltefilnk qitdsngkss nikilntkgc rvqliqnymk skkidikgqk // LOCUS NP_015371 181 aa linear PLN 30-JUN-2025 DEFINITION Mcm16p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015371 VERSION NP_015371.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184143.1 REFERENCE 1 (residues 1 to 181) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 181) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 181) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 181) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 181) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11470. Method: conceptual translation. FEATURES Location/Qualifiers source 1..181 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..181 /product="Mcm16p" /calculated_mol_wt="21007" CDS 1..181 /gene="MCM16" /locus_tag="YPR046W" /coded_by="NM_001184143.1:1..546" /experiment="EXISTENCE:direct assay:GO:0000776 kinetochore [PMID:11782448]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:11782448]" /experiment="EXISTENCE:mutant phenotype:GO:0034087 establishment of mitotic sister chromatid cohesion [PMID:19730685]" /note="Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3" /db_xref="GeneID:856159" /db_xref="SGD:S000006250" ORIGIN 1 mtnssekqwe riqqlekehv evyrellitl drlylirkhn havilshtqq rlleirhqlq 61 inlektalli rllekpdntn vlftklqnll eesnsldyel lqslgaqssl hkqliesrae 121 rdelmsklie lsskfpkpti ppddsdtagk qvevekenet iqelmialqi hsgytnisyt 181 i // LOCUS NP_015372 469 aa linear PLN 30-JUN-2025 DEFINITION phenylalanine--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015372 VERSION NP_015372.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184144.1 REFERENCE 1 (residues 1 to 469) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 469) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 469) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 469) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 469) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11471. On Oct 2, 2003 this sequence version replaced NP_015372.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..469 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..469 /product="phenylalanine--tRNA ligase" /EC_number="6.1.1.20" /calculated_mol_wt="54698" Region 18..468 /region_name="pheS_mito" /note="phenylalanyl-tRNA synthetase, mitochondrial; TIGR00469" /db_xref="CDD:129561" CDS 1..469 /gene="MSF1" /locus_tag="YPR047W" /coded_by="NM_001184144.1:1..1410" /experiment="EXISTENCE:direct assay:GO:0004826 phenylalanine-tRNA ligase activity [PMID:16162501]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0004826 phenylalanine-tRNA ligase activity [PMID:3029120]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:3029120]" /experiment="EXISTENCE:mutant phenotype:GO:0070156 mitochondrial phenylalanyl-tRNA aminoacylation [PMID:3029120]" /note="Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase" /db_xref="GeneID:856160" /db_xref="SGD:S000006251" ORIGIN 1 mflnrmmktr tglyrlystl kvphveingi kyktdpqttn vtdsiikltd rslhlkeshp 61 vgilrdliek klnsvdntfk ifnnfkpvvt tmenfdslgf pkdhpgrsks dtyyinethl 121 lrthtsahel ecfqkirnds dniksgflis advyrrdeid kthypvfhqm egatiwkrtk 181 advgvkepmy iekiredirq venllnkenv kitvdddtip lkennpkqey msdlevdlcs 241 qhlkrsieli vsevfnkkis smiknkannt pkelkvrwin ayfpwtapsw eievwwqgew 301 lelcgcglir qdvllragyk psetigwafg lgldriamll feipdirllw srderfsrqf 361 skglitsfkp yskhpgsfrd vafwlpedkp dihqvhendl meiirniagd lvesvklvds 421 fthpktgrks mcyrinyqsm drnltnaevn tlqdmvcskl vkeysvelr // LOCUS NP_015373 623 aa linear PLN 30-JUN-2025 DEFINITION NAPDH-dependent diflavin reductase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015373 VERSION NP_015373.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184145.1 REFERENCE 1 (residues 1 to 623) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 623) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 623) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 623) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 623) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11472. Method: conceptual translation. FEATURES Location/Qualifiers source 1..623 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..623 /product="NAPDH-dependent diflavin reductase" /calculated_mol_wt="72197" Region 9..143 /region_name="Flavodoxin_1" /note="pfam00258" /db_xref="CDD:425562" Region 230..623 /region_name="FNR_like" /note="Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; cl06868" /db_xref="CDD:447143" Site order(266,413..416,429..431,445..448,486) /site_type="other" /note="FAD binding pocket [chemical binding]" /db_xref="CDD:99778" Site order(413,415..416) /site_type="other" /note="conserved FAD binding motif [chemical binding]" /db_xref="CDD:99778" Site order(445,448,451,457) /site_type="other" /note="phosphate binding motif [ion binding]" /db_xref="CDD:99778" Site order(481,485..488,490) /site_type="other" /note="beta-alpha-beta structure motif" /db_xref="CDD:99778" Site order(486..487,508..510,576..577) /site_type="other" /note="NAD binding pocket [chemical binding]" /db_xref="CDD:99778" CDS 1..623 /gene="TAH18" /locus_tag="YPR048W" /coded_by="NM_001184145.1:1..1872" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:19194512]" /experiment="EXISTENCE:direct assay:GO:0160246 NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity [PMID:20802492]" /experiment="EXISTENCE:mutant phenotype:GO:0006809 nitric oxide biosynthetic process [PMID:23159617]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:20802492]" /experiment="EXISTENCE:mutant phenotype:GO:0045429 positive regulation of nitric oxide biosynthetic process [PMID:27178802]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:27178802]" /note="Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance; possible target for development of antifungal drugs" /db_xref="GeneID:856161" /db_xref="SGD:S000006252" ORIGIN 1 mssskkivil ygsetgnahd fatilshrlh rwhfshtfcs igdydpqdil kcrylfiics 61 ttgqgelprn vnalkgerpv tfwsflkrkn lpsnllnhiq tamlglgdss ypkfnygirk 121 lhqrivtqlg anelfdrlea ddqamagsnk gtglgiesvy feyekkvlsf llskypnrkv 181 ngqiikreel dpevylepas ylqlsdehan ekftstkvif egdeslkvgr vninkritse 241 ghfqdvrqfk fsnvdkiqen yepgdtvtiy pcntdedvsr flanqshwle iadkplnfts 301 gvpndlkdgg lvrpmtlrnl lkyhcdfmsi prtsfflkiw tfatdvtkme rgqeqlndqr 361 eklrqfatdq dmqdlydycn rprrsilevl edfisvklpw kyvldylpii kpryysissg 421 pgdpnieltv aivkyktilr kirrgictny iarlqegeqi ryklqnnhii kkeflnkpmi 481 lvgpgvglap llsvvkaeis kdikllfgcr ykdkdyiykd mledwfrkgk ialhssfsrd 541 eenspgvkyv qdylwrlgee itnlvvnkda vfflcgssgk mpiqvrltfi emlkkwgnfs 601 deetakkylk emeksdryiq etw // LOCUS NP_015374 1178 aa linear PLN 30-JUN-2025 DEFINITION autophagy protein ATG11 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015374 VERSION NP_015374.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184146.1 REFERENCE 1 (residues 1 to 1178) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1178) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1178) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1178) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1178) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11473. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1178 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1178 /product="autophagy protein ATG11" /calculated_mol_wt="134894" Region 175..508 /region_name="ATG17_like" /note="Autophagy protein ATG17-like domain; pfam04108" /db_xref="CDD:427715" Region <697..>865 /region_name="Mplasa_alph_rch" /note="helix-rich Mycoplasma protein; TIGR04523" /db_xref="CDD:275316" Region 992..1171 /region_name="ATG11" /note="Autophagy-related protein 11; pfam10377" /db_xref="CDD:463063" CDS 1..1178 /gene="ATG11" /locus_tag="YPR049C" /gene_synonym="CVT3; CVT9" /coded_by="NM_001184146.1:1..3537" /experiment="EXISTENCE:direct assay:GO:0000045 autophagosome assembly [PMID:18725539]" /experiment="EXISTENCE:direct assay:GO:0000149 SNARE binding [PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:15659643]" /experiment="EXISTENCE:direct assay:GO:0005774 vacuolar membrane [PMID:40173187]" /experiment="EXISTENCE:direct assay:GO:0006914 autophagy [PMID:28013049]" /experiment="EXISTENCE:direct assay:GO:0006995 cellular response to nitrogen starvation [PMID:18725539|PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0034497 protein localization to phagophore assembly site [PMID:23858448|PMID:26774783]" /experiment="EXISTENCE:direct assay:GO:0071957 old mitotic spindle pole body [PMID:40173187]" /experiment="EXISTENCE:genetic interaction:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:15659643]" /experiment="EXISTENCE:genetic interaction:GO:0060090 molecular adaptor activity [PMID:17295840]" /experiment="EXISTENCE:genetic interaction:GO:2000786 positive regulation of autophagosome assembly [PMID:18077553]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:11309418]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:40173187]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:12479808]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:15659643]" /experiment="EXISTENCE:mutant phenotype:GO:0034517 ribophagy [PMID:27659307]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:26181331]" /note="Adapter protein for pexophagy and the Cvt targeting pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the PAS; recruits Dnm1p to facilitate fission of mitochondria that are destined for removal by mitophagy; dynamic association with the daughter (old) SPB is involved in microtubule-mediated chromosome segregation" /db_xref="GeneID:856162" /db_xref="SGD:S000006253" ORIGIN 1 madadeysta ptqqeitplq ttatiinais gecittnvdf fvsldkfkqf iarkwkippd 61 qllillpygn klkpsmfkel linrsftlnd fyvydrrlfs lvskptptnl ltskdsnpmn 121 spnsndltet leyliknshi sqyqgsdtim ikpmpspled advdlsrlny hsvtsllttn 181 lgwlsaleid vhyfkslipd iiahikrifd gltvcsqylk lycfdvesly nsnvqflnql 241 vdngmtskwe kcfndtlskl talegdslqk finiesllen eksvkilnhs ingklnkikr 301 eidenasfrd iitvnidrlr qmftpneskf eledqmaesf evlvsemrtr srnvldkeee 361 efnsqeflks mnvmlekdkk esvktlftis qalysqigel idlkkslqkh availgniaf 421 tqmeilgikr lllnecnkdl elykkyevef aqvedlpliy glyliekyrr lswfqqilsf 481 isnfnqdlel fkqnelrtrn kwvknfgsia tvfcedllss sdfkrlneyh shtsppnede 541 edenensian yrqdlvkvsq aidnymtqik etdvsepiid llsktlfetk rfhiiysnfk 601 nnnnnssngn sispegsial ksddvvkgyk trikklesll hefqysdigh wpqgvlnthl 661 kpfrgsatsi nkkkflgasv llepanisev nidsvsqann hqiqelesnv ddllhqlqll 721 keennrksmq isemgkkisd levektayre tltnlnqela rltneeqshr teiftlnasf 781 kkqlndiisq dnekiekltg dyddvsksre rlqmdldesn kkheqevnll kadierlgkq 841 ivtseksyae tnsssmekge kfetiplaed pgrenqisay tqtlqdrifd iistnifile 901 nigllltfdn nnniqirrvk glkkgtaqsn ildestqmld ahdnsliksp vfqklkdeye 961 liksvangse kdtqqsiflg nitqlydnkl yevavirrfk dietlakklt kenkikrtll 1021 erfqrekvtl rnfqigdlal flptrenvns vgsmssstss lsssfssvdl stpppldams 1081 iqsspsvihs nvinqasisg rdknklmrpw aaftafeest ryflkdekgl tkgkewfvgr 1141 ivtlehfvad spsnnpfrlp kgsvwfqvta vvvsyqgv // LOCUS NP_015376 176 aa linear PLN 30-JUN-2025 DEFINITION peptide alpha-N-acetyltransferase MAK3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015376 VERSION NP_015376.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184148.1 REFERENCE 1 (residues 1 to 176) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 176) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 176) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 176) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 176) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11474. Method: conceptual translation. FEATURES Location/Qualifiers source 1..176 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..176 /product="peptide alpha-N-acetyltransferase MAK3" /EC_number="2.3.1.256" /calculated_mol_wt="20326" Region 16..135 /region_name="Acetyltransf_1" /note="Acetyltransferase (GNAT) family; pfam00583" /db_xref="CDD:395465" Site order(84..86,96..97) /site_type="other" /note="Coenzyme A binding pocket [chemical binding]" /db_xref="CDD:173926" CDS 1..176 /gene="MAK3" /locus_tag="YPR051W" /gene_synonym="NAA30" /coded_by="NM_001184148.1:1..531" /experiment="EXISTENCE:direct assay:GO:0031417 NatC complex [PMID:10504710]" /experiment="EXISTENCE:mutant phenotype:GO:0004596 protein-N-terminal amino-acid acetyltransferase activity [PMID:11274203]" /experiment="EXISTENCE:mutant phenotype:GO:0006474 N-terminal protein amino acid acetylation [PMID:11274203]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:15911569|PMID:17261844|PMID:15077113|PMID:15077114]" /note="Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT); involved in subcellular targeting of select N-terminally acetylated substrates to the Golgi apparatus (Arl3p and Grh1p) and the inner nuclear membrane (Trm1p); required for replication of dsRNA virus; human NatC ortholog, NAA30, functionally complements the null, requiring either auxiliary subunit Mak10p or co-expression of human ortholog, NAA35; NAA60, the human NatF gene, also complements the null allele" /db_xref="GeneID:856163" /db_xref="SGD:S000006255" ORIGIN 1 meivykpldi rneeqfasik klidadlsep ysiyvyryfl nqwpeltyia vdnksgtpni 61 pigcivckmd phrnvrlrgy igmlavesty rghgiakklv eiaidkmqre hcdeimlete 121 vensaalnly egmgfirmkr mfryylnegd afklilplte ksctrstflm hgrlat // LOCUS NP_015377 93 aa linear PLN 30-JUN-2025 DEFINITION high-mobility group nucleosome-binding protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_015377 VERSION NP_015377.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184149.1 REFERENCE 1 (residues 1 to 93) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 93) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 93) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 93) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 93) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11475. Method: conceptual translation. FEATURES Location/Qualifiers source 1..93 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..93 /product="high-mobility group nucleosome-binding protein" /calculated_mol_wt="10671" Region 17..88 /region_name="HMG-box_NHP6-like" /note="high mobility group (HMG)-box found in Saccharomyces cerevisiae non-histone chromosomal proteins NHP6A, NHP6B and similar proteins; cd01390" /db_xref="CDD:438792" CDS 1..93 /gene="NHP6A" /locus_tag="YPR052C" /coded_by="NM_001184149.1:1..282" /experiment="EXISTENCE:direct assay:GO:0001195 maintenance of transcriptional fidelity during transcription elongation by RNA polymerase III [PMID:16407207]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:3169249|PMID:17878171]" /experiment="EXISTENCE:direct assay:GO:0006325 chromatin organization [PMID:19683499]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:7721780|PMID:9468494]" /experiment="EXISTENCE:direct assay:GO:0031491 nucleosome binding [PMID:11432837|PMID:12952948|PMID:12805231]" /experiment="EXISTENCE:direct assay:GO:0032407 MutSalpha complex binding [PMID:19843605]" /experiment="EXISTENCE:direct assay:GO:0043392 negative regulation of DNA binding [PMID:19843605]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:8946917]" /experiment="EXISTENCE:direct assay:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:16407207|PMID:17178828|PMID:11239460]" /experiment="EXISTENCE:genetic interaction:GO:0006338 chromatin remodeling [PMID:14739928]" /experiment="EXISTENCE:genetic interaction:GO:0070898 RNA polymerase III preinitiation complex assembly [PMID:11533232]" /note="High-mobility group (HMG) protein; binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to chromosomes; functionally redundant with Nhp6Bp; required for transcriptional initiation fidelity of some tRNA genes; homologous to mammalian HMGB1 and HMGB2; NHP6A has a paralog, NHP6B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856165" /db_xref="SGD:S000006256" ORIGIN 1 mvtprepkkr ttrkkkdpna pkralsaymf fanenrdivr senpditfgq vgkklgekwk 61 altpeekqpy eakaqadkkr yesekelyna tla // LOCUS NP_001335825 151 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR053C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335825 VERSION NP_001335825.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348887.1 REFERENCE 1 (residues 1 to 151) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 151) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 151) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 151) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 151) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80345. Method: conceptual translation. FEATURES Location/Qualifiers source 1..151 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..151 /product="uncharacterized protein" /calculated_mol_wt="17388" CDS 1..151 /locus_tag="YPR053C" /coded_by="NM_001348887.1:1..456" /note="hypothetical protein; conserved among S. cerevisiae strains; YPR053C is not an essential gene; partially overlaps verified ORF NHP6A/YPR052C" /db_xref="GeneID:856166" /db_xref="SGD:S000006257" ORIGIN 1 mmyrttlntv qvsqisgaef yphassrail fespafcrlf fspfvylavg kqttqylllv 61 ptvkeglfwd vffscfcsid ypihskaqsq wspqenlrre plerrrtqmp lrglcpptcf 121 sltkteilfv lkiqishldk sarswvrsgr l // LOCUS NP_015379 388 aa linear PLN 30-JUN-2025 DEFINITION mitogen-activated protein kinase SMK1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015379 VERSION NP_015379.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184151.1 REFERENCE 1 (residues 1 to 388) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 388) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 388) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 388) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 388) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 388) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 388) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11476. Method: conceptual translation. FEATURES Location/Qualifiers source 1..388 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..388 /product="mitogen-activated protein kinase SMK1" /EC_number="2.7.11.24" /calculated_mol_wt="44169" Region 37..376 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(44..47,50,52,67,69,101,121..124,166,170..171,173, 183..184) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..388 /gene="SMK1" /locus_tag="YPR054W" /coded_by="NM_001184151.1:1..1167" /experiment="EXISTENCE:direct assay:GO:0004707 MAP kinase activity [PMID:16116083]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0070056 prospore membrane leading edge [PMID:33466572]" /experiment="EXISTENCE:genetic interaction:GO:0030476 ascospore wall assembly [PMID:38874213|PMID:16116083]" /experiment="EXISTENCE:mutant phenotype:GO:0004707 MAP kinase activity [PMID:16116083]" /experiment="EXISTENCE:mutant phenotype:GO:0030476 ascospore wall assembly [PMID:16116083|PMID:7958885]" /experiment="EXISTENCE:mutant phenotype:GO:1904853 protein localization to ascospore wall [PMID:38874213]" /note="Middle sporulation-specific mitogen-activated protein kinase (MAPK); required for prospore membrane development and the production of outer spore wall layers; promotes deposition of the glucan layer of the spore wall by regulating the localization of Gsc2p to sites of spore wall assembly in postmeiotic cells; activated by Cak1p-mediated phosphorylation of threonine (T207) in the activation loop during meiosis I followed by Ssp2p-promoted autophosphorylation of tyrosine (T209) during meiosis II" /db_xref="GeneID:856167" /db_xref="SGD:S000006258" ORIGIN 1 mnctltdntr ainvasnlga pqqrtifake risipgyyei iqflgkgayg tvcsvkfkgr 61 spaariavkk isnifnkeil lkrairelkf mnffkghkni vnlidleivt sspydglycy 121 qelidydlak vihssvqlse fhikyflyqi lcglkyihsa dvihrdlkpg nilctlngcl 181 kicdfglarg ihagffkchs tvqphitnyv atrwyrapel llsnqpysks vdiwavgcil 241 aefyarkpvf mgrdsmhqif eiikvlgtpd kdilikfgti kawnlgknsn npvykkipws 301 nifpfashea inliesllhw dsthrlnveq aishpflnev rkpddepvcl qgpfdftyes 361 elnsmsklrd ylveevknfk tdlssssl // LOCUS NP_015380 1065 aa linear PLN 30-JUN-2025 DEFINITION exocyst subunit SEC8 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015380 VERSION NP_015380.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184152.1 REFERENCE 1 (residues 1 to 1065) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1065) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1065) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1065) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1065) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1065) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1065) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11477. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1065 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1065 /product="exocyst subunit SEC8" /calculated_mol_wt="122094" Region 34..174 /region_name="Sec8_exocyst" /note="Sec8 exocyst complex component specific domain; pfam04048" /db_xref="CDD:367782" CDS 1..1065 /gene="SEC8" /locus_tag="YPR055W" /coded_by="NM_001184152.1:1..3198" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:9491896]" /experiment="EXISTENCE:direct assay:GO:0000145 exocyst [PMID:1512289|PMID:7615633|PMID:8978675]" /experiment="EXISTENCE:direct assay:GO:0005628 prospore membrane [PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:7615633|PMID:9491896|PMID:12960429|PMID:22842922|PMI D:17717527]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:22842922|PMID:12960429|PMID:9491896]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:genetic interaction:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:mutant phenotype:GO:0006887 exocytosis [PMID:6996832]" /experiment="EXISTENCE:mutant phenotype:GO:0006893 Golgi to plasma membrane transport [PMID:7026045]" /experiment="EXISTENCE:mutant phenotype:GO:0048309 endoplasmic reticulum inheritance [PMID:15596717]" /experiment="EXISTENCE:mutant phenotype:GO:0048313 Golgi inheritance [PMID:15596717]" /note="Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress" /db_xref="GeneID:856168" /db_xref="SGD:S000006259" ORIGIN 1 mdylkpaqkg rrrglsinsl setqqsamns sldhlqndln rinlqwnril sdntnplela 61 laflddtsvg lghryeefnq lksqigshlq dvvnehsqvf ntnvasygka vssimqaqeq 121 tlnlknclke anekittdkg slqelndnnl kytkmidvlv nieellqipe kieenirken 181 fhqvqiller gfilmnnksl ktveilkpin qqlelqehll fnnlieeihd imysksnktn 241 ftrvtnndif kiisishngf tslenylyni vnidimehsk tinknleqfi hdqslnkgni 301 mlqenaatqa plapsrnqen egfnrigfll ktinninklp vafniitera keeihniivk 361 stesirskhp sllkmatslk ndnhfglpvq dilsiilrec fweiflklly aiqchraife 421 msnilqptss akpafkfnki wgklldeiel llvryindpe lissnngsik pingatnnap 481 tlpkrknpki fsleyniedn ssvkdqafel kallkdifpg fsvssnmdld siyvkdesfe 541 qdeplvppsv fnmkvildpf llftqststi vpsvltqnti ssltffddym nksflpkiqm 601 tmdylftvev esnnpyalel sdenhnifkt aldfqrlfyn llnvfntant frekisycil 661 dllnhfynyy lglfnsligt sdrhltrkii tawlqngilm dqeqkilngd etlfheesie 721 lfkeiphfyq agkglsksdl fnnltldtil qfsasvlwil nwlpglkkai nidevsqepm 781 ldadrlrssw tfsesmdlny snpssspnsl gnlkillddk askkfdetid gfktlkfkli 841 tilrfniral ciydigsffq ntkiwnmdvg sieldqnias liselrrtes klkqqlpeke 901 knsifigldi vnnyalikga ksikvlnhng ikkmlrnvnv lqhayrnlss epskinmnvt 961 mnfyslcgss eaelfeyikd nelphcsved lktilrlqfs eemhrqlkrq stsstkgsik 1021 psnkryteal eklsnlekeq skegartkig klksklnavh tanek // LOCUS NP_015381 338 aa linear PLN 30-JUN-2025 DEFINITION TFIIH/NER complex subunit TFB4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015381 VERSION NP_015381.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184153.1 REFERENCE 1 (residues 1 to 338) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 338) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 338) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 338) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 338) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11478. Method: conceptual translation. FEATURES Location/Qualifiers source 1..338 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..338 /product="TFIIH/NER complex subunit TFB4" /calculated_mol_wt="37326" Region 1..331 /region_name="TFB4" /note="RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4 [Transcription / DNA replication, recombination, and repair]; COG5242" /db_xref="CDD:227567" CDS 1..338 /gene="TFB4" /locus_tag="YPR056W" /coded_by="NM_001184153.1:1..1017" /experiment="EXISTENCE:curator inference:GO:0016251 RNA polymerase II general transcription initiation factor activity [PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0000439 transcription factor TFIIH core complex [PMID:14500720|PMID:19818408]" /experiment="EXISTENCE:direct assay:GO:0005675 transcription factor TFIIH holo complex [PMID:19818408|PMID:27381459]" /experiment="EXISTENCE:direct assay:GO:0006366 transcription by RNA polymerase II [PMID:19818408]" /experiment="EXISTENCE:mutant phenotype:GO:0006289 nucleotide-excision repair [PMID:10506223]" /experiment="EXISTENCE:physical interaction:GO:0000112 nucleotide-excision repair factor 3 complex [PMID:10681587]" /note="Subunit of TFIIH complex; involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p" /db_xref="GeneID:856169" /db_xref="SGD:S000006260" ORIGIN 1 mdaisdptfk harsrkqvte espslltvii eiapklwttf deegnekgsi ikvlealivf 61 lnahlafnsa nkvaviaays qgikylypes tsalkasese nktrsdlkii nsdmyrrfrn 121 vdetlveeiy klfelekkqi eqnsqrstla gamsagltyv nriskesvtt slksrllvlt 181 cgsgsskdei fqyipimnci fsatkmkcpi dvvkiggske stflqqttda tngvylhves 241 tegliqylat amfidpslrp iivkpnhgsv dfrtscyltg rvvavgfics vclcvlsiip 301 pgnkcpacds qfdehviakl krkpvvprlk akkkvtkp // LOCUS NP_015382 341 aa linear PLN 30-JUN-2025 DEFINITION Brr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015382 VERSION NP_015382.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184154.1 REFERENCE 1 (residues 1 to 341) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 341) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 341) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 341) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 341) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11479. Method: conceptual translation. FEATURES Location/Qualifiers source 1..341 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..341 /product="Brr1p" /calculated_mol_wt="39729" Region 142..337 /region_name="SIP1" /note="Survival motor neuron (SMN) interacting protein 1 (SIP1); pfam04938" /db_xref="CDD:461493" CDS 1..341 /gene="BRR1" /locus_tag="YPR057W" /coded_by="NM_001184154.1:1..1026" /experiment="EXISTENCE:direct assay:GO:0017069 snRNA binding [PMID:8861964]" /experiment="EXISTENCE:direct assay:GO:0030532 small nuclear ribonucleoprotein complex [PMID:8861964]" /experiment="EXISTENCE:mutant phenotype:GO:0000245 spliceosomal complex assembly [PMID:8861964]" /note="snRNP protein component of spliceosomal snRNPs; required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed" /db_xref="GeneID:856170" /db_xref="SGD:S000006261" ORIGIN 1 mkrgesqapd aifgqsrafa lsdssvnpdv ieylksvrqe alrtnaisik nhmnlqkrtr 61 hkssmydded egalkrhais pslirlqrnv eiwvrwfnsv katvltnaye ftgyedetld 121 llllflknyl edmpskcttv ekiisvlnqh sfpekaeeke enlqideewa knilvrlekt 181 kidsvedvkk vitegdkhel vgynqwfqyl innepqhttf hekitskqlw vlikymsntw 241 ikeihkkgrh yrrlqdwlfy ilvhtpervt aeytsilrdl gkkcleliqk kpveahenki 301 tlpkemaeln veipaavenm titeltvsvi avnygqkdli e // LOCUS NP_015383 307 aa linear PLN 30-JUN-2025 DEFINITION organic acid transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_015383 VERSION NP_015383.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184155.1 REFERENCE 1 (residues 1 to 307) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 307) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 307) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 307) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 307) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11480. Method: conceptual translation. FEATURES Location/Qualifiers source 1..307 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..307 /product="organic acid transporter" /calculated_mol_wt="33245" Region 25..111 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 116..201 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 215..307 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..307 /gene="YMC1" /locus_tag="YPR058W" /coded_by="NM_001184155.1:1..924" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:16823961|PMID:16140254]" /experiment="EXISTENCE:genetic interaction:GO:0005342 organic acid transmembrane transporter activity [PMID:16140254]" /experiment="EXISTENCE:genetic interaction:GO:0006783 heme biosynthetic process [PMID:26821380]" /experiment="EXISTENCE:genetic interaction:GO:0006839 mitochondrial transport [PMID:16140254]" /experiment="EXISTENCE:genetic interaction:GO:0015187 glycine transmembrane transporter activity [PMID:26821380]" /experiment="EXISTENCE:genetic interaction:GO:1904983 glycine import into mitochondrion [PMID:26821380]" /note="Secondary mitochondrial inner membrane glycine transporter; required with HEM25 for the transport of glycine into mitochondria for the initiation of heme biosynthesis; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; localizes to the vacuole in response to H2O2; YMC1 has a paralog, YMC2, that arose from the whole genome duplication" /db_xref="GeneID:856171" /db_xref="SGD:S000006262" ORIGIN 1 mseefpspql iddleehpqh dnarvvkdll agtaggiaqv lvgqpfdttk vrlqtsstpt 61 tamevvrkll anegprgfyk gtltpligvg acvslqfgvn eamkrffhhr nadmsstlsl 121 pqyyacgvtg givnsflasp iehvrirlqt qtgsgtnaef kgplecikkl rhnkallrgl 181 tptilreghg cgtyflvyea lianqmnkrr glerkdipaw klcifgalsg talwlmvypl 241 dviksvmqtd nlqkpkfgns issvaktlya nggigaffkg fgptmlraap angatfatfe 301 lamrllg // LOCUS NP_015385 256 aa linear PLN 30-JUN-2025 DEFINITION chorismate mutase ARO7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015385 VERSION NP_015385.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184157.1 REFERENCE 1 (residues 1 to 256) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 256) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 256) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 256) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 256) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11481. Method: conceptual translation. FEATURES Location/Qualifiers source 1..256 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..256 /product="chorismate mutase ARO7" /EC_number="5.4.99.5" /calculated_mol_wt="29616" Region 10..255 /region_name="CM_pl-yst" /note="monofunctional chorismate mutase, eukaryotic type; TIGR01802" /db_xref="CDD:273812" CDS 1..256 /gene="ARO7" /locus_tag="YPR060C" /gene_synonym="HGS1; OSM2; TYR7" /coded_by="NM_001184157.1:1..771" /experiment="EXISTENCE:direct assay:GO:0004106 chorismate mutase activity [PMID:3027508]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0006571 tyrosine biosynthetic process [PMID:3027508]" /experiment="EXISTENCE:mutant phenotype:GO:0009094 L-phenylalanine biosynthetic process [PMID:3027508]" /note="Chorismate mutase; catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis" /db_xref="GeneID:856173" /db_xref="SGD:S000006264" ORIGIN 1 mdftkpetvl nlqnirdelv rmedsiifkf iershfatcp svyeanhpgl eipnfkgsfl 61 dwalsnleia hsrirrfesp detpffpdki qksflpsiny pqilapyape vnyndkikkv 121 yiekiiplis krdgddknnf gsvatrdiec lqslsrrihf gkfvaeakfq sdiplytkli 181 kskdvegimk nitnsaveek ilerltkkae vygvdptnes gerritpeyl vkiykeivip 241 itkeveveyl lrrlee // LOCUS NP_015386 301 aa linear PLN 30-JUN-2025 DEFINITION Jid1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015386 VERSION NP_015386.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184158.1 REFERENCE 1 (residues 1 to 301) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 301) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 301) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 301) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 301) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11482. Method: conceptual translation. FEATURES Location/Qualifiers source 1..301 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..301 /product="Jid1p" /calculated_mol_wt="34897" Region <84..147 /region_name="DnaJ" /note="DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; cl02542" /db_xref="CDD:413365" Site order(92..94,124,127..128,131..132) /site_type="other" /note="HSP70 interaction site [polypeptide binding]" /db_xref="CDD:99751" CDS 1..301 /gene="JID1" /locus_tag="YPR061C" /coded_by="NM_001184158.1:1..906" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095|PMID:17054397]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:19682992]" /note="Probable Hsp40p co-chaperone; has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae" /db_xref="GeneID:856174" /db_xref="SGD:S000006265" ORIGIN 1 mlhhkfvypf lfkwhlscve kcppqitfia kyatandkng nrkltirdeq wpeladptpy 61 difgipkags gnpkldkksl kkkyhryvkl yhpdhsdniq ifssekvtns dsksplllts 121 seklhrfkvi sqaydilcdp kkkivydttr qgwttsyspr snvntenyqy agsygyhsna 181 qyeywnagtw edansmkner iqeninpwtv igiicglaic iegtallaki qeslskaeft 241 hdesglhliq sytnygldtd kfsrlrrflw frtwglyksk edldreakin eemirklkaa 301 k // LOCUS NP_015387 158 aa linear PLN 30-JUN-2025 DEFINITION cytosine deaminase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015387 VERSION NP_015387.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184159.1 REFERENCE 1 (residues 1 to 158) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 158) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 158) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 158) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 158) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11483. Method: conceptual translation. FEATURES Location/Qualifiers source 1..158 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..158 /product="cytosine deaminase" /EC_number="3.5.4.1" /calculated_mol_wt="17376" Region 15..109 /region_name="cytidine_deaminase-like" /note="Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; cd00786" /db_xref="CDD:238406" Site order(62..64,90..91,94) /site_type="active" /db_xref="CDD:238406" Site order(62,64,91,94) /site_type="other" /note="Zn binding site [ion binding]" /db_xref="CDD:238406" CDS 1..158 /gene="FCY1" /locus_tag="YPR062W" /coded_by="NM_001184159.1:1..477" /experiment="EXISTENCE:direct assay:GO:0004131 cytosine deaminase activity [PMID:9000374|PMID:15535715]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0008655 pyrimidine-containing compound salvage [PMID:9000374]" /experiment="EXISTENCE:mutant phenotype:GO:0019858 cytosine metabolic process [PMID:9000374]" /experiment="EXISTENCE:mutant phenotype:GO:0046087 cytidine metabolic process [PMID:10501935]" /note="Cytosine deaminase; zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)" /db_xref="GeneID:856175" /db_xref="SGD:S000006266" ORIGIN 1 mvtggmaskw dqkgmdiaye eaalgykegg vpiggclinn kdgsvlgrgh nmrfqkgsat 61 lhgeistlen cgrlegkvyk dttlyttlsp cdmctgaiim ygiprcvvge nvnfkskgek 121 ylqtrghevv vvdderckki mkqfiderpq dwfedige // LOCUS NP_015388 140 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR063C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015388 VERSION NP_015388.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184160.1 REFERENCE 1 (residues 1 to 140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 140) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11484. Method: conceptual translation. FEATURES Location/Qualifiers source 1..140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..140 /product="uncharacterized protein" /calculated_mol_wt="15310" CDS 1..140 /locus_tag="YPR063C" /coded_by="NM_001184160.1:1..423" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:14562095]" /note="ER-localized hypothetical protein" /db_xref="GeneID:856176" /db_xref="SGD:S000006267" ORIGIN 1 mtlnnvarpd lcvsykkiap pkglysatps isgvvnqsmp maaiflrnkf iawfsliqsv 61 hyylntdedi ivaykenkap spmdqppaik lfmsliglcv cymnlvfpqq iaqpsssgsk 121 gntettiett tevetetakq // LOCUS NP_001335826 139 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR064W [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335826 VERSION NP_001335826.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348888.1 REFERENCE 1 (residues 1 to 139) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 139) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 139) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 139) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 139) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80346. Method: conceptual translation. FEATURES Location/Qualifiers source 1..139 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..139 /product="uncharacterized protein" /calculated_mol_wt="15530" CDS 1..139 /locus_tag="YPR064W" /coded_by="NM_001348888.1:1..420" /note="hypothetical protein; conserved among S. cerevisiae strains; YPR064W is not an essential gene" /db_xref="GeneID:856177" /db_xref="SGD:S000006268" ORIGIN 1 mkscvlsnyv egleiivcgy rnrllfpfra tqvqayfkvf sffffllltl gaaaaakpts 61 erqvifgsad kspgyhwpve vsaawnyrel lcktignlvg kpcsrtwrll tkkkrayccc 121 lfccsssycl agvlcvfcv // LOCUS NP_015390 368 aa linear PLN 30-JUN-2025 DEFINITION Rox1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015390 VERSION NP_015390.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184162.1 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11485. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..368 /product="Rox1p" /calculated_mol_wt="41707" Region 10..86 /region_name="HMG-box_ROX1-like" /note="high mobility group (HMG)-box found in Saccharomyces cerevisiae repressor ROX1 and similar proteins; cd01389" /db_xref="CDD:438791" Site order(11..12,14..18,21..22,29,46..47,50,53..54,61,65,68,72, 75) /site_type="other" /note="putative DNA binding site [nucleotide binding]" /db_xref="CDD:438791" CDS 1..368 /gene="ROX1" /locus_tag="YPR065W" /gene_synonym="REO1" /coded_by="NM_001184162.1:1..1107" /experiment="EXISTENCE:curator inference:GO:0000785 chromatin [PMID:10446242|PMID:10487921|PMID:7565763|PMID:8413209]" /experiment="EXISTENCE:direct assay:GO:0000987 cis-regulatory region sequence-specific DNA binding [PMID:10487921]" /experiment="EXISTENCE:direct assay:GO:0008301 DNA binding, bending [PMID:10446242|PMID:7565763]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:10446242|PMID:8413209]" /experiment="EXISTENCE:genetic interaction:GO:0071470 cellular response to osmotic stress [PMID:23435728]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:10446242|PMID:1588959|PMID:16835445|PMID:9388292|PMI D:12051835|PMID:2546055|PMID:12095998|PMID:3062365|PMID:10 487921|PMID:21299653|PMID:2847035]" /experiment="EXISTENCE:mutant phenotype:GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific [PMID:10446242]" /experiment="EXISTENCE:mutant phenotype:GO:0003714 transcription corepressor activity [PMID:14665463]" /experiment="EXISTENCE:mutant phenotype:GO:0036295 cellular response to increased oxygen levels [PMID:9388292|PMID:10446242|PMID:2847035|PMID:12051835|PMI D:1588959|PMID:12095998|PMID:2546055|PMID:3062365|PMID:104 87921|PMID:16835445]" /experiment="EXISTENCE:mutant phenotype:GO:0071470 cellular response to osmotic stress [PMID:23435728]" /experiment="EXISTENCE:mutant phenotype:GO:0071472 cellular response to salt stress [PMID:21299653]" /note="Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance" /db_xref="GeneID:856178" /db_xref="SGD:S000006269" ORIGIN 1 mnpksstpki prpknafilf rqhyhrilid ewtaqgveip hnsniskiig tkwkglqped 61 kahwenlaek ekleherkyp eykykpvrks kkkqlllkei eqqqqqqqke qqqqkqsqpq 121 lqqpfnnniv lmkrahslsp sssvsssnsy qfqlnndlkr lpipsvntsn ymvsrslsgl 181 plthdktard lpqlssqlns ipyysaphdp strhhylnva qaqpranstp qlpfissiin 241 nssqtpvttt ttstttatss pgkfssspns svlennrlns innsnqylpp pllpslqdfq 301 ldqyqqlkqm gptyivkpls htrnnllstt tpthhhiphi pnqniplhqi inssntevta 361 ktslvspk // LOCUS NP_015391 299 aa linear PLN 30-JUN-2025 DEFINITION NEDD8-activating protein UBA3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015391 VERSION NP_015391.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184163.1 REFERENCE 1 (residues 1 to 299) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 299) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 299) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 299) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 299) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11486. Method: conceptual translation. FEATURES Location/Qualifiers source 1..299 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..299 /product="NEDD8-activating protein UBA3" /EC_number="6.2.1.64" /calculated_mol_wt="33147" Region 4..294 /region_name="Uba3_RUB" /note="Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...; cd01488" /db_xref="CDD:238765" Site order(9,11,13,34,36,45,58,99,105) /site_type="other" /note="putative ATP binding site [chemical binding]" /db_xref="CDD:238765" Site order(11,13,100..101,106,133..134,138..139,153,156,159,161, 268,270,272,278,280,282..283,285) /site_type="other" /note="substrate interface [chemical binding]" /db_xref="CDD:238765" Site order(16,19,23,41,43..45,47..48,50,65..66,68..69,136,224, 227..228,233..238,242) /site_type="other" /note="dimer interaction [polypeptide binding]" /db_xref="CDD:238765" Site order(150,153,290,293) /site_type="other" /note="zinc binding site [ion binding]" /db_xref="CDD:238765" Site 168 /site_type="active" /note="catalytic residue [active]" /db_xref="CDD:238765" CDS 1..299 /gene="UBA3" /locus_tag="YPR066W" /coded_by="NM_001184163.1:1..900" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0019781 NEDD8 activating enzyme activity [PMID:9545234]" /experiment="EXISTENCE:direct assay:GO:0045116 protein neddylation [PMID:9545234]" /experiment="EXISTENCE:mutant phenotype:GO:0045116 protein neddylation [PMID:9545234]" /note="Protein that activates Rub1p (NEDD8) before neddylation; acts together with Ula1p; may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern" /db_xref="GeneID:856179" /db_xref="SGD:S000006270" ORIGIN 1 mdckilvlga gglgceilkn ltmlsfvkqv hivdidtiel tnlnrqflfc dkdigkpkaq 61 vaaqyvntrf pqlevvahvq dlttlppsfy kdfqfiisgl daieprrfin etlvkltles 121 nyeicipfid ggteglkghv ktiipgitac wecsidtlps qqdtvpmcti annprciehv 181 veyvstiqyp dlniestadm efllekccer aaqfsistek lstsfilgii ksiipsvstt 241 namvaatcct qmvkiyndli dlengnnftl incsegcfmy sfkferlpdc tvcsnsnsn // LOCUS NP_015392 185 aa linear PLN 30-JUN-2025 DEFINITION Isa2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015392 VERSION NP_015392.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184164.1 REFERENCE 1 (residues 1 to 185) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 185) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 185) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 185) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 185) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11487. Method: conceptual translation. FEATURES Location/Qualifiers source 1..185 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..185 /product="Isa2p" /calculated_mol_wt="20746" Region 58..183 /region_name="IscA" /note="Fe-S cluster assembly iron-binding protein IscA [Posttranslational modification, protein turnover, chaperones]; COG0316" /db_xref="CDD:440085" CDS 1..185 /gene="ISA2" /locus_tag="YPR067W" /coded_by="NM_001184164.1:1..558" /experiment="EXISTENCE:direct assay:GO:0005506 iron ion binding [PMID:21987576]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005758 mitochondrial intermembrane space [PMID:10805735]" /experiment="EXISTENCE:direct assay:GO:0005759 mitochondrial matrix [PMID:10913600]" /experiment="EXISTENCE:genetic interaction:GO:0009102 biotin biosynthetic process [PMID:17259550]" /experiment="EXISTENCE:genetic interaction:GO:0016226 iron-sulfur cluster assembly [PMID:10805735]" /experiment="EXISTENCE:mutant phenotype:GO:0009102 biotin biosynthetic process [PMID:17259550]" /experiment="EXISTENCE:mutant phenotype:GO:0016226 iron-sulfur cluster assembly [PMID:10805735|PMID:10913600]" /experiment="EXISTENCE:mutant phenotype:GO:0044572 [4Fe-4S] cluster assembly [PMID:21987576]" /note="Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations" /db_xref="GeneID:856180" /db_xref="SGD:S000006271" ORIGIN 1 mqakllftrl nfrrpsttlr qfpltcflfh skafysdlvt keplitpkri inktpglnls 61 iserasnrla eiyrnskenl risvesggch gfqynltlep atkpdikndv kdkefsddld 121 dddskdiiyv lpedkgrvii dskslnilnn ttltytneli gssfkiings lksscgcgss 181 fdien // LOCUS NP_015393 470 aa linear PLN 30-JUN-2025 DEFINITION histone deacetylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015393 VERSION NP_015393.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184165.1 REFERENCE 1 (residues 1 to 470) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 470) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 470) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 470) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11488. Method: conceptual translation. FEATURES Location/Qualifiers source 1..470 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..470 /product="histone deacetylase" /EC_number="3.5.1.98" /calculated_mol_wt="54633" Region 5..390 /region_name="HDAC_Hos1" /note="Class I histone deacetylases Hos1 and related proteins; cd11680" /db_xref="CDD:212543" Site order(210..211,219..220,247,249,333,340,372,374) /site_type="active" /db_xref="CDD:212543" CDS 1..470 /gene="HOS1" /locus_tag="YPR068C" /gene_synonym="CST3" /coded_by="NM_001184165.1:1..1413" /experiment="EXISTENCE:direct assay:GO:0033558 protein lysine deacetylase activity [PMID:20832720|PMID:20797861]" /experiment="EXISTENCE:mutant phenotype:GO:0033558 protein lysine deacetylase activity [PMID:20832720|PMID:20797861]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:17706600]" /experiment="EXISTENCE:physical interaction:GO:0000118 histone deacetylase complex [PMID:22543816]" /note="Class I histone deacetylase (HDAC) family member; deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex" /db_xref="GeneID:856181" /db_xref="SGD:S000006272" ORIGIN 1 msklvistsi fqsqvadllp cnnhqksqlt yslinaydll qhfdevltfp yarkddllef 61 hsksyidyli ngrfnkmmaq dvnnpmvesk wselseladn wnekidynps qdlqrfttre 121 nlynyylnhs qalennmdci nnsevptndk ptdtyilnse tkqynlegdc pifsylpmyc 181 qvitgatlnl ldhlspterl iginwdggrh hafkqrasgf cyindvvlli qrlrkaklnk 241 ityvdfdlhh gdgvekafqy skqiqtisvh lyepgffpgt gslsdsrkdk nvvniplkhg 301 cddnylelia skivnplier hepealiiec ggdgllgdrf newqltirgl sriiinimks 361 yprahifllg gggyndllms rfytyltwcv tkqfsnlrcg dnnsfqidpf dvcdgddseq 421 firehdlvem yneenyqywi yemegssrmk mlrndnkdrd mvelmkfyel // LOCUS NP_015394 293 aa linear PLN 30-JUN-2025 DEFINITION spermidine synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015394 VERSION NP_015394.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184166.1 REFERENCE 1 (residues 1 to 293) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 293) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 293) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 293) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 293) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11489. Method: conceptual translation. FEATURES Location/Qualifiers source 1..293 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..293 /product="spermidine synthase" /EC_number="2.5.1.16" /calculated_mol_wt="33193" Region 14..287 /region_name="speE" /note="spermidine synthase; TIGR00417" /db_xref="CDD:188048" Site order(95..101,119..120,149..151,171) /site_type="other" /note="S-adenosylmethionine binding site [chemical binding]" /db_xref="CDD:100107" CDS 1..293 /gene="SPE3" /locus_tag="YPR069C" /coded_by="NM_001184166.1:1..882" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:mutant phenotype:GO:0004766 spermidine synthase activity [PMID:9073064]" /experiment="EXISTENCE:mutant phenotype:GO:0008295 spermidine biosynthetic process [PMID:9073064]" /experiment="EXISTENCE:mutant phenotype:GO:0015940 pantothenate biosynthetic process [PMID:11154694]" /note="Spermidine synthase; involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells" /db_xref="GeneID:856182" /db_xref="SGD:S000006273" ORIGIN 1 maqeithpti vdgwfreisd tmwpgqamtl kvekvlhhek skyqdvlifk sttygnvlvl 61 dnviqaterd efayqemiah lalnshpnpk kvlvigggdg gvlrevvkhd sveeawlcdi 121 deavirlske ylpemaasys hpkvkthigd gfqflrdyqn tfdviitdss dpegpaetlf 181 qkeyfqllns altekgvitt qaesmwihlp iikdlkkacs evfpvaeysf vtiptyptgt 241 igfmvcskdk tcnvkkplre isdekeaely ryynkkihea sfvlptwaak eln // LOCUS NP_015395 566 aa linear PLN 30-JUN-2025 DEFINITION Med1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015395 VERSION NP_015395.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184167.1 REFERENCE 1 (residues 1 to 566) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 566) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 566) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 566) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 566) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11490. Method: conceptual translation. FEATURES Location/Qualifiers source 1..566 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..566 /product="Med1p" /calculated_mol_wt="64120" Region 12..>173 /region_name="Med1" /note="Mediator of RNA polymerase II transcription subunit 1; pfam10744" /db_xref="CDD:463183" CDS 1..566 /gene="MED1" /locus_tag="YPR070W" /coded_by="NM_001184167.1:1..1701" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9892641]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9892641]" /note="Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation" /db_xref="GeneID:856183" /db_xref="SGD:S000006274" ORIGIN 1 mvegdsyvet ldsmielfkd ykpgsitlen itrlcqtlgl esfteelsne lsrlstaski 61 ividvdynkk qdriqdvklv lasnfdnfdy fnqrdgehek snillnsltk ypdlkafhnn 121 lkflyllday shiesdstsh nngssdksld ssnasfnnqg kldlfkyfte lshyirqcfq 181 dnccdfkvrt nlndkfgiyi ltqgingkev plakiyleen ksdsqyrfye yiysqetksw 241 inesaenfsn gislvmeiva nakesnytdl iwfpedfisp eliidkvtcs snssssppii 301 dlfsnnnyns riqlmndftt klinikkfdi sndnldlise ilkwvqwsri vlqnvfklvs 361 tpssnsnsse lepdyqapfs tstkdknsst sntepiprsn rhgsvveasr rrrsstnksk 421 rpsiteamml keeglqqfnl heilsepaie eengdsikeh sttmdgandl gftasvsnqe 481 nagtdivmed hgvlqgtsqn ygtataddad iemkdvsskp skpessvlql ivsedhiild 541 tisecnlydd vkcwskfiek fqdivs // LOCUS NP_015396 211 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR071W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015396 VERSION NP_015396.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184168.1 REFERENCE 1 (residues 1 to 211) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 211) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 211) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 211) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 211) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11491. Method: conceptual translation. FEATURES Location/Qualifiers source 1..211 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..211 /product="uncharacterized protein" /calculated_mol_wt="24475" Region 29..196 /region_name="DUF4668" /note="Domain of unknown function (DUF4668); pfam15701" /db_xref="CDD:406192" CDS 1..211 /locus_tag="YPR071W" /coded_by="NM_001184168.1:1..636" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="Putative membrane protein; YPR071W is not an essential gene; YPR071W has a paralog, YIL029C, that arose from a single-locus duplication" /db_xref="GeneID:856184" /db_xref="SGD:S000006275" ORIGIN 1 mqngtedksn iparsnddvl pplavrltmk vmrlifigkm faysfvpfpp fklltfdntv 61 gwfvaysaiv siwgfavwme rgyrhkinll pprctkircs rcntrirspn wfkyknwlyf 121 fllyvsltts nliiqlasfm temsrrgisv pgtkdpgkrd ylgliipmrf igafihymta 181 nlfkeyylhn gplekndrps tdektsenet l // LOCUS NP_015397 560 aa linear PLN 30-JUN-2025 DEFINITION CCR4-NOT core subunit NOT5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015397 VERSION NP_015397.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184169.1 REFERENCE 1 (residues 1 to 560) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 560) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 560) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 560) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 560) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11492. Method: conceptual translation. FEATURES Location/Qualifiers source 1..560 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..560 /product="CCR4-NOT core subunit NOT5" /calculated_mol_wt="65724" Region 2..210 /region_name="Not3" /note="Not1 N-terminal domain, CCR4-Not complex component; pfam04065" /db_xref="CDD:461155" Region 386..555 /region_name="NOT2_3_5" /note="NOT2 / NOT3 / NOT5 family; pfam04153" /db_xref="CDD:461199" CDS 1..560 /gene="NOT5" /locus_tag="YPR072W" /coded_by="NM_001184169.1:1..1683" /experiment="EXISTENCE:direct assay:GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11889048]" /experiment="EXISTENCE:direct assay:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:21406554]" /experiment="EXISTENCE:mutant phenotype:GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA [PMID:26952104]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:11404327]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:16926149]" /experiment="EXISTENCE:mutant phenotype:GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA [PMID:15706350]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:26952104]" /experiment="EXISTENCE:physical interaction:GO:0030015 CCR4-NOT core complex [PMID:10490603]" /note="Component of the CCR4-NOT core complex, involved in mRNA decapping; involved intranscription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not5p and Not3p is mutated in cancers" /db_xref="GeneID:856186" /db_xref="SGD:S000006276" ORIGIN 1 msqrklqqdi dkllkkvkeg iedfddiyek fqstdpsnss hreklesdlk reikklqkhr 61 dqiktwlske dvkdkqsvlm tnrrliengm erfksveklm ktkqfskeal tnpdiikdpk 121 elkkrdqvlf ihdcldelqk qleqyeaqen eeqterhefh ianlenilkk lqnnemdpep 181 veefqddiky yvennddpdf ieydtiyedm gceiqpsssn neapkegnnq tslssirssk 241 kqerspkkka pqrdvsisdr attpiapgve sasqsisstp tpvstdtplh tvkddsikfd 301 nstlgtptth vsmkkkesen dseqqlnfpp drtdeirkti qhdvetnaaf qnplfndelk 361 ywldskrylm qplqemspkm vsqlesslln cpdsldadsp clytkplslp hptsiffpne 421 pirfvypydv plnltnnend tdnkfgkdsk akskkdddiy srtslarifm kfdldtlffi 481 fyhyqgsyeq flaarelfkn rnwlfnkvdr cwyykeiekl ppgmgkseee swryfdykks 541 wlarrcgndf vyneedfekl // LOCUS NP_015398 161 aa linear PLN 30-JUN-2025 DEFINITION tyrosine protein phosphatase LTP1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015398 VERSION NP_015398.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184170.1 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11493. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..161 /product="tyrosine protein phosphatase LTP1" /EC_number="3.1.3.2" /EC_number="3.1.3.48" /calculated_mol_wt="18544" Region 9..158 /region_name="LMWP" /note="Low molecular weight phosphatase family; cd00115" /db_xref="CDD:319970" Site order(14,16..21,133,135) /site_type="active" /db_xref="CDD:319970" CDS 1..161 /gene="LTP1" /locus_tag="YPR073C" /coded_by="NM_001184170.1:1..486" /experiment="EXISTENCE:direct assay:GO:0004725 protein tyrosine phosphatase activity [PMID:7629177|PMID:15358193]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0006470 protein dephosphorylation [PMID:7629177]" /experiment="EXISTENCE:mutant phenotype:GO:0004725 protein tyrosine phosphatase activity [PMID:7629177]" /note="Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine" /db_xref="GeneID:856187" /db_xref="SGD:S000006277" ORIGIN 1 mtiekpkisv aficlgnfcr spmaeaifkh evekanlenr fnkidsfgts nyhvgespdh 61 rtvsickqhg vkinhkgkqi ktkhfdeydy iigmdesnin nlkkiqpegs kakvclfgdw 121 ntndgtvqti iedpwygdiq dfeynfkqit yfskqflkke l // LOCUS NP_015399 680 aa linear PLN 30-JUN-2025 DEFINITION transketolase TKL1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015399 VERSION NP_015399.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184171.1 REFERENCE 1 (residues 1 to 680) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 680) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 680) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 680) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 680) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 680) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 680) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11494. Method: conceptual translation. FEATURES Location/Qualifiers source 1..680 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..680 /product="transketolase TKL1" /EC_number="2.2.1.1" /calculated_mol_wt="73675" Region 9..664 /region_name="tktlase_bact" /note="transketolase, bacterial and yeast; TIGR00232" /db_xref="CDD:272974" CDS 1..680 /gene="TKL1" /locus_tag="YPR074C" /coded_by="NM_001184171.1:1..2043" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:8299150]" /experiment="EXISTENCE:mutant phenotype:GO:0004802 transketolase activity [PMID:8226984]" /experiment="EXISTENCE:mutant phenotype:GO:0006098 pentose-phosphate shunt [PMID:8299150]" /note="Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication" /db_xref="GeneID:856188" /db_xref="SGD:S000006278" ORIGIN 1 mtqftdidkl avstirilav dtvskansgh pgaplgmapa ahvlwsqmrm nptnpdwinr 61 drfvlsngha vallysmlhl tgydlsiedl kqfrqlgsrt pghpefelpg vevttgplgq 121 gisnavgmam aqanlaatyn kpgftlsdny tyvflgdgcl qegisseass laghlklgnl 181 iaiyddnkit idgatsisfd edvakryeay gwevlyveng nedlagiaka iaqaklskdk 241 ptlikmttti gygslhagsh svhgaplkad dvkqlkskfg fnpdksfvvp qevydhyqkt 301 ilkpgveann kwnklfseyq kkfpelgael arrlsgqlpa nwesklptyt akdsavatrk 361 lsetvledvy nqlpeliggs adltpsnltr wkealdfqpp ssgsgnysgr yirygireha 421 mgaimngisa fganykpygg tflnfvsyaa gavrlsalsg hpviwvathd sigvgedgpt 481 hqpietlahf rslpniqvwr padgnevsaa yknsleskht psiialsrqn lpqlegssie 541 saskggyvlq dvanpdiilv atgsevslsv eaaktlaakn ikarvvslpd fftfdkqple 601 yrlsvlpdnv pimsvevlat tcwgkyahqs fgidrfgasg kapevfkffg ftpegvaera 661 qktiafykgd klisplkkaf // LOCUS NP_015400 360 aa linear PLN 30-JUN-2025 DEFINITION Opy2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015400 VERSION NP_015400.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184172.1 REFERENCE 1 (residues 1 to 360) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 360) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 360) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 360) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 360) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11495. Method: conceptual translation. FEATURES Location/Qualifiers source 1..360 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..360 /product="Opy2p" /calculated_mol_wt="38770" Region 30..63 /region_name="Opy2" /note="Opy2 protein; pfam09463" /db_xref="CDD:430628" CDS 1..360 /gene="OPY2" /locus_tag="YPR075C" /coded_by="NM_001184172.1:1..1083" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16543225|PMID:22842922]" /experiment="EXISTENCE:genetic interaction:GO:0007231 osmosensory signaling pathway [PMID:16543225]" /experiment="EXISTENCE:genetic interaction:GO:0072659 protein localization to plasma membrane [PMID:22904036|PMID:17627274]" /experiment="EXISTENCE:mutant phenotype:GO:0000751 mitotic cell cycle G1 arrest in response to pheromone [PMID:9383053]" /experiment="EXISTENCE:mutant phenotype:GO:1900436 positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [PMID:22904036]" /experiment="EXISTENCE:physical interaction:GO:0007231 osmosensory signaling pathway [PMID:16543225]" /note="Integral membrane protein that acts as a membrane anchor for Ste50p; involved in the signaling branch of the high-osmolarity glycerol (HOG) pathway and as a regulator of the filamentous growth pathway; overproduction blocks cell cycle arrest in the presence of mating pheromone; relocalizes from vacuole to plasma membrane upon DNA replication stress" /db_xref="GeneID:856191" /db_xref="SGD:S000006279" ORIGIN 1 msssskasas sslsstatss tsatrgsdgc vvcdstascp vcasgeycvm tsltcdkcps 61 tycakqsdsq lsslssssss ssssnsnekt slivgftvgi vggamlialv alyfinkryw 121 kpkrqknkal kleeasqsyg neeeyfdded dddeddeddg gmrkdeshtl fntslvpptl 181 nvpgnrssas ttrtrasnil piayipgvts glstdklqsk lrssskrqna agdirshitl 241 gssildgldd eddehnqvln kdaddnlita irakpklvqi aeeesdkeiq dldvieeqte 301 addlshmaks eashgnnded ddeegsfild leipesires tqgsrtespf edkfeihder // LOCUS NP_015403 372 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR078C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015403 VERSION NP_015403.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184175.1 REFERENCE 1 (residues 1 to 372) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 372) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 372) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 372) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 372) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11496. Method: conceptual translation. FEATURES Location/Qualifiers source 1..372 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..372 /product="uncharacterized protein" /calculated_mol_wt="42463" CDS 1..372 /locus_tag="YPR078C" /coded_by="NM_001184175.1:1..1119" /note="hypothetical protein; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible" /db_xref="GeneID:856193" /db_xref="SGD:S000006282" ORIGIN 1 mqtisgvlpt vlspselrsd dertfqfdee aeitthltes edlrrlinet aqlgvrvdhi 61 hdktdqeiar lekvikevte sdtffrscsg wfktnknfsd sesssntqlk slsqlhgryd 121 rdwrqrlnkw frknksklal psdnnleevn ddkvygyged lmergktpyf sdiddfmngl 181 niispltpdd fenddtlvki detcqihsas epektsispt fgknikkelv tddtesiisg 241 pplqenkktl lkyryvrtsl dmlgseksss knnsggmfri fhksanfgdk nqenvprvwd 301 tlrnnlgrei yllqgrfkkw ttkhqnlkkg qpckdedavt vplpssdpgk etqletklcf 361 vpepgdqplv qa // LOCUS NP_015404 381 aa linear PLN 30-JUN-2025 DEFINITION Mrl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015404 VERSION NP_015404.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184176.1 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11497. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..381 /product="Mrl1p" /calculated_mol_wt="42575" CDS 1..381 /gene="MRL1" /locus_tag="YPR079W" /coded_by="NM_001184176.1:1..1146" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005770 late endosome [PMID:11470415]" /experiment="EXISTENCE:genetic interaction:GO:0005048 signal sequence binding [PMID:11470415]" /experiment="EXISTENCE:mutant phenotype:GO:0007034 vacuolar transport [PMID:11470415]" /note="Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856194" /db_xref="SGD:S000006283" ORIGIN 1 mlkrssliyl scvliitipi llhvyngpgl sheanehras hkqkrtlanp dkpksended 61 lfcavtnpvt gsyidlsqls stpnklregq kqisgnnkhe ssktkwsvrg wgydtnftlg 121 icsspvgeae sqqlsnltga fyvdqlnenn lvsigdfstr palvggstak kltlkyengs 181 mcpngkdkka tllnfvcdke iqskaqisyi gnlhncsyff evrsihacpt snkknevnvl 241 gifigifaif flvefagrrw iyaklnrhlk nddelhdisp slneqphwdl iedgsrwskf 301 fngiikttrr ftkslmrslv rgrnsrqggi rlrsspsass sslanreffr dmeaqneiid 361 sldinshtte sdhptladns v // LOCUS NP_015405 458 aa linear PLN 30-JUN-2025 DEFINITION translation elongation factor EF-1 alpha [Saccharomyces cerevisiae S288C]. ACCESSION NP_015405 VERSION NP_015405.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184177.1 REFERENCE 1 (residues 1 to 458) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 458) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 458) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 458) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 458) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11498. Method: conceptual translation. FEATURES Location/Qualifiers source 1..458 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..458 /product="translation elongation factor EF-1 alpha" /calculated_mol_wt="49902" Region 1..443 /region_name="PTZ00141" /note="elongation factor 1- alpha; Provisional" /db_xref="CDD:185474" Site 14..21 /site_type="other" /note="G1 box" /db_xref="CDD:206670" Site order(15,17,21..22,25,28..29,76..77,95..96,119..120,167, 171) /site_type="other" /note="putative GEF interaction site [polypeptide binding]" /db_xref="CDD:206670" Site order(17,19..22,153..154,156,192..194) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206670" Site order(21,64,67..68,70,72,74..76,78,89,91,93..95,97,100) /site_type="other" /note="EF1Balpha binding site [polypeptide binding]" /db_xref="CDD:206670" Site 66..76 /site_type="other" /note="Switch I region" /db_xref="CDD:206670" Site 72 /site_type="other" /note="G2 box" /db_xref="CDD:206670" Site 91..94 /site_type="other" /note="G3 box" /db_xref="CDD:206670" Site 93..111 /site_type="other" /note="Switch II region" /db_xref="CDD:206670" Site 153..156 /site_type="other" /note="G4 box" /db_xref="CDD:206670" Site 192..194 /site_type="other" /note="G5 box" /db_xref="CDD:206670" CDS 1..458 /gene="TEF1" /locus_tag="YPR080W" /coded_by="NM_001184177.1:1..1377" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:25561732]" /experiment="EXISTENCE:direct assay:GO:0005525 GTP binding [PMID:17925388]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20032305]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0019003 GDP binding [PMID:17925388]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:25561732]" /experiment="EXISTENCE:direct assay:GO:0051017 actin filament bundle assembly [PMID:19095653|PMID:16116436|PMID:25561732]" /experiment="EXISTENCE:direct assay:GO:1904408 melatonin binding [PMID:31708896]" /experiment="EXISTENCE:genetic interaction:GO:0006409 tRNA export from nucleus [PMID:17203074|PMID:10766739]" /experiment="EXISTENCE:mutant phenotype:GO:0003746 translation elongation factor activity [PMID:10514524]" /experiment="EXISTENCE:mutant phenotype:GO:0006409 tRNA export from nucleus [PMID:17203074|PMID:10766739]" /experiment="EXISTENCE:mutant phenotype:GO:0006414 translational elongation [PMID:10514524]" /experiment="EXISTENCE:mutant phenotype:GO:0051017 actin filament bundle assembly [PMID:16116436]" /experiment="EXISTENCE:physical interaction:GO:0005739 mitochondrion [PMID:16962558]" /note="Translational elongation factor EF-1 alpha; GTP-bound active form, binds to and delivers aminoacylated tRNA to the A-site of ribosomes for elongation of nascent polypeptides; moonlighting function as an actin binding and bundling protein; association with GTPase Rho1p on the vacuolar membrane may facilitate F-actin remodeling; involved in tRNA re-export from the nucleus" /db_xref="GeneID:856195" /db_xref="SGD:S000006284" ORIGIN 1 mgkekshinv vvighvdsgk stttghliyk cggidkrtie kfekeaaelg kgsfkyawvl 61 dklkaererg itidialwkf etpkyqvtvi dapghrdfik nmitgtsqad cailiiaggv 121 gefeagiskd gqtrehalla ftlgvrqliv avnkmdsvkw desrfqeivk etsnfikkvg 181 ynpktvpfvp isgwngdnmi eattnapwyk gweketkagv vkgktlleai daieqpsrpt 241 dkplrlplqd vykiggigtv pvgrvetgvi kpgmvvtfap agvttevksv emhheqleqg 301 vpgdnvgfnv knvsvkeirr gnvcgdaknd ppkgcasfna tvivlnhpgq isagyspvld 361 chtahiacrf dellekndrr sgkkledhpk flksgdaalv kfvpskpmcv eafseypplg 421 rfavrdmrqt vavgviksvd ktekaakvtk aaqkaakk // LOCUS NP_015406 618 aa linear PLN 30-JUN-2025 DEFINITION putative glycine--tRNA ligase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015406 VERSION NP_015406.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184178.1 REFERENCE 1 (residues 1 to 618) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 618) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 618) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 618) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 618) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11499. Method: conceptual translation. FEATURES Location/Qualifiers source 1..618 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..618 /product="putative glycine--tRNA ligase" /EC_number="6.1.1.14" /calculated_mol_wt="70888" Region 7..598 /region_name="glyS_dimeric" /note="glycyl-tRNA synthetase, dimeric type; TIGR00389" /db_xref="CDD:273051" CDS 1..618 /gene="GRS2" /locus_tag="YPR081C" /coded_by="NM_001184178.1:1..1857" /experiment="EXISTENCE:direct assay:GO:0004820 glycine-tRNA ligase activity [PMID:21877692|PMID:22438917]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:21877692]" /experiment="EXISTENCE:genetic interaction:GO:0004820 glycine-tRNA ligase activity [PMID:22438917]" /experiment="EXISTENCE:genetic interaction:GO:0006426 glycyl-tRNA aminoacylation [PMID:22438917]" /note="Glycine-tRNA synthetase, not expressed under normal growth conditions; expression is induced under heat, oxidative, pH, or ethanol stress conditions; more stable than the major glycine-tRNA synthetase Grs1p at 37 deg C; GRS2 has a paralog, GRS1, that arose from the whole genome duplication" /db_xref="GeneID:856196" /db_xref="SGD:S000006285" ORIGIN 1 mplmsnserd klestlrrrf fytpsfeiyg gvsglfdlgp pgcqlqnnli rlwrehfime 61 enmlqvdgpm ltpydvlkts ghvdkftdwm crnpktgeyy radhlieqtl kkrlldkdvn 121 pqdmknmeki lttidgfsgp elnlvmqeyn indpvtndvl daltsfnlmf etkigasgql 181 kaflrpetaq gqflnfnkll einqgkipfa sasigksfrn eisprsgllr vreflmaeie 241 hfvdplnksh akfnevlnee ipllsrrlqe sgevqlpvkm tigeavnsgm venetlgyfm 301 arvhqfllni ginkdkfrfr qhlknemahy atdcwdgeil tsygwiecvg cadraafdlt 361 vhskktgrsl tvkqkldtpk ertewvvevn kkffgskfkq kakliesvls kfsqdelirr 421 heelekngef tcqvngqivk ldsslvtikm kttlqhirey ipnviepsfg lgriiycifd 481 hcfqvrvdse srgffsfplq iapikvfvtt isnndgfpai lkrisqalrk reiyfkidds 541 ntsigkkyar ndelgtpfgi tidfetikdq tvtlrernsm rqvrgtitdv istidkmlhn 601 pdesdwdkst fglspvki // LOCUS NP_015407 143 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit DIB1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015407 VERSION NP_015407.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184179.1 REFERENCE 1 (residues 1 to 143) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 143) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 143) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 143) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 143) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11500. Method: conceptual translation. FEATURES Location/Qualifiers source 1..143 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..143 /product="U4/U6-U5 snRNP complex subunit DIB1" /calculated_mol_wt="16645" Region 5..137 /region_name="DIM1" /note="Mitosis protein DIM1; pfam02966" /db_xref="CDD:460768" CDS 1..143 /gene="DIB1" /locus_tag="YPR082C" /gene_synonym="SNU16" /coded_by="NM_001184179.1:1..432" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:10610776|PMID:11720284]" /note="17-kDa component of the U4/U6aU5 tri-snRNP; plays an essential role in pre-mRNA splicing; human ortholog TXNL4A (the human U5-specific 15-kDa protein) complements yeast dib1 null mutant" /db_xref="GeneID:856197" /db_xref="SGD:S000006286" ORIGIN 1 masvllpqlr tgwhvdqaiv tetkrlvvir fgrkndrqcm imdellssia ervrnfaviy 61 lcdidevsdf demyeltdpm tvmffyhnkh mmcdfgtgnn nklnfivddk qemidileti 121 frgarknkgl vvspydynhk rvs // LOCUS NP_015408 579 aa linear PLN 30-JUN-2025 DEFINITION Mdm36p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015408 VERSION NP_015408.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184180.1 REFERENCE 1 (residues 1 to 579) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 579) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 579) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 579) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 579) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11501. Method: conceptual translation. FEATURES Location/Qualifiers source 1..579 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..579 /product="Mdm36p" /calculated_mol_wt="64828" CDS 1..579 /gene="MDM36" /locus_tag="YPR083W" /coded_by="NM_001184180.1:1..1740" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:20505073]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:20505073]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:23641071]" /experiment="EXISTENCE:mutant phenotype:GO:0000266 mitochondrial fission [PMID:20505073]" /experiment="EXISTENCE:mutant phenotype:GO:0007005 mitochondrion organization [PMID:11907266]" /experiment="EXISTENCE:mutant phenotype:GO:0048312 intracellular distribution of mitochondria [PMID:20505073]" /note="Mitochondrial protein; required for normal mitochondrial morphology and inheritance; component of the mitochondria-ER-cortex-anchor (MECA); interacts with Num1p to link the ER and mitochondria at the cell cortex; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission" /db_xref="GeneID:856198" /db_xref="SGD:S000006287" ORIGIN 1 mdengtvkpg yelkglnsgn srsnmdkdpi vskfhragln dsadeedtdi ngnrntswit 61 smiseekrkv egksmlndee dlhlskatln kcdalvkila diiklefvih qswyirslhk 121 svliqfevet sggnknsagd sgdddddnhn gnlddsfykd lslkcikkce ksslalesls 181 rdidqirdfi msntiednrv drllqnsmtl llecwiysmk rlrrlrmkia gifvrsklll 241 idhelvtiwh flqeqnehet vnnenelkla etiksyrafi kifiqqleds esgspssslf 301 eeclhvfldi esmynslnln wllnenkalq erllspssts endhtnnlpv idetkeiedi 361 ssfvnsivda smlthdltpi nssdsdnlsn geidrldgrr lssstsdmsl mmqrtslqkq 421 lpslltafnn arrleqelqn ackvndnkhs tkdtdsnirr nehamsssvs siisqnstla 481 spsppmsssf istapsqsss rmstlplsps ssllesqsqt lknnmsqwln qsrsglngtk 541 liptnhigfh snvlntlygi gggpvsksyk snqpssqnt // LOCUS NP_015409 456 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR084W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015409 VERSION NP_015409.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184181.1 REFERENCE 1 (residues 1 to 456) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 456) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 456) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 456) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 456) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11502. Method: conceptual translation. FEATURES Location/Qualifiers source 1..456 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..456 /product="uncharacterized protein" /calculated_mol_wt="50704" CDS 1..456 /locus_tag="YPR084W" /coded_by="NM_001184181.1:1..1371" /note="hypothetical protein" /db_xref="GeneID:856199" /db_xref="SGD:S000006288" ORIGIN 1 msekaseerp irlavlggts tgktslvsrl tvnivhevhy ptrnqtnwlf gfvpssilar 61 aildeqaher lclrspssqt lepifpspqv sknvllsplv fqastdnfqs vrlhnkshsr 121 rslsldksds plyqtfsndi nsqsvpkika dqlnviehfk lplnyippty apiqidiidt 181 pgfspdnvvp flevslfrnl gksilhglad eprrpvstts llvasgasel ngkvdgyilv 241 ysavpelnhi ggppeygddv mntdtenvsd ggfellkvir ncildawtef rnyekrweeg 301 keddiyslvy slrhlwskns keksakieql rsyntklksi eldpsspdsp ppciivcshv 361 nhelaspmli emgrqlatkw kygfvgidsm ddlnvdvavs llikeisekm kllvsnsngs 421 sssgnsssiy nshlmndkkk nnnaglnknm lkkiik // LOCUS NP_015410 443 aa linear PLN 30-JUN-2025 DEFINITION Asa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015410 VERSION NP_015410.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184182.1 REFERENCE 1 (residues 1 to 443) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 443) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 443) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 443) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11503. On Oct 2, 2003 this sequence version replaced NP_015410.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..443 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..443 /product="Asa1p" /calculated_mol_wt="50432" CDS 1..443 /gene="ASA1" /locus_tag="YPR085C" /coded_by="NM_001184182.1:1..1332" /experiment="EXISTENCE:direct assay:GO:0110078 TTT Hsp90 cochaperone complex [PMID:19040720]" /note="Subunit of the TTT complex and regulator of telomere length; subunit of the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1" /db_xref="GeneID:856200" /db_xref="SGD:S000006289" ORIGIN 1 mrgfsneiil krtltlsdft lryhkrgita lqvikapsvs nvpvllsgdn ygyfvmwdlv 61 tkrpithiei egnshiiafw wvettnvlyi lskdsmlrif eldsstqlsi dlvrklsqan 121 ktdhlqwtki yempintlnf anfiieaevk ptkdnksyrl vcchtddset idiyqiieds 181 tfklkrpfnn infprflkqq nflgiskdsk fgiimrfakl ndviflgyen gfvvgfkitf 241 deglqrdiae lvhvsndhyp npildmcvsg delyscstdd fitkykipvn lqletkylrd 301 dallikcpss lrvsepskvh lplknighid kvkddylvvs swsgmtivyn mrtseveqtf 361 vksknnlvvs dssmgdltng sgsntesssk shnykvgamt clesfdvqsd glrlgqlrri 421 kalakcnwcl igyedgtikl nki // LOCUS NP_015411 345 aa linear PLN 30-JUN-2025 DEFINITION transcription factor SUA7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015411 VERSION NP_015411.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184183.1 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11504. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..345 /product="transcription factor SUA7" /calculated_mol_wt="38069" Region 23..316 /region_name="SUA7" /note="Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB [Transcription]; COG1405" /db_xref="CDD:441015" CDS 1..345 /gene="SUA7" /locus_tag="YPR086W" /gene_synonym="SOH4" /coded_by="NM_001184183.1:1..1038" /experiment="EXISTENCE:direct assay:GO:0000993 RNA polymerase II complex binding [PMID:7935466]" /experiment="EXISTENCE:direct assay:GO:0001139 RNA polymerase II complex recruiting activity [PMID:10464320]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15888545]" /experiment="EXISTENCE:direct assay:GO:0017025 TBP-class protein binding [PMID:10464320|PMID:15888545]" /experiment="EXISTENCE:direct assay:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:10464320]" /experiment="EXISTENCE:direct assay:GO:0097550 transcription preinitiation complex [PMID:22751016]" /experiment="EXISTENCE:direct assay:GO:2000679 positive regulation of transcription regulatory region DNA binding [PMID:8132551]" /experiment="EXISTENCE:mutant phenotype:GO:0001113 transcription open complex formation at RNA polymerase II promoter [PMID:19820686]" /experiment="EXISTENCE:mutant phenotype:GO:0001139 RNA polymerase II complex recruiting activity [PMID:10464320]" /experiment="EXISTENCE:mutant phenotype:GO:0001174 transcriptional start site selection at RNA polymerase II promoter [PMID:19820686]" /experiment="EXISTENCE:mutant phenotype:GO:0017025 TBP-class protein binding [PMID:10464320]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:9887099|PMID:10464320]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:7935466]" /experiment="EXISTENCE:physical interaction:GO:0017025 TBP-class protein binding [PMID:15888545]" /note="Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II" /db_xref="GeneID:856201" /db_xref="SGD:S000006290" ORIGIN 1 mmtresidkr agrrgpnlni vltcpeckvy ppkiverfse gdvvcalcgl vlsdklvdtr 61 sewrtfsndd hngddpsrvg easnplldgn nlstrigkge ttdmrftkel nkaqgknvmd 121 kkdnevqaaf akitmlcdaa elpkivkdca keayklchde ktlkgksmes imaasiligc 181 rraevartfk eiqslihvkt kefgktlnim knilrgksed gflkidtdnm sgaqnltyip 241 rfcshlglpm qvttsaeyta kkckeikeia gkspitiavv siylnillfq ipitaakvgq 301 tlqvtegtik sgykilyehr dklvdpqlia ngvvsldnlp gvekk // LOCUS NP_015413 541 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding signal recognition particle subunit SRP54 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015413 VERSION NP_015413.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184185.1 REFERENCE 1 (residues 1 to 541) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 541) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 541) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 541) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 541) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11505. Method: conceptual translation. FEATURES Location/Qualifiers source 1..541 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..541 /product="RNA-binding signal recognition particle subunit SRP54" /EC_number="3.6.5.4" /calculated_mol_wt="59494" Region 2..436 /region_name="SRP54_euk" /note="signal recognition particle protein SRP54; TIGR01425" /db_xref="CDD:273615" CDS 1..541 /gene="SRP54" /locus_tag="YPR088C" /gene_synonym="SRH1" /coded_by="NM_001184185.1:1..1626" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005786 signal recognition particle, endoplasmic reticulum targeting [PMID:7925282]" /experiment="EXISTENCE:direct assay:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:10921896]" /experiment="EXISTENCE:direct assay:GO:0008312 7S RNA binding [PMID:14681587]" /experiment="EXISTENCE:mutant phenotype:GO:0006614 SRP-dependent cotranslational protein targeting to membrane [PMID:1655273]" /note="Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain" /db_xref="GeneID:856203" /db_xref="SGD:S000006292" ORIGIN 1 mvladlgkri nsavnnaisn tqddfttsvd vmlkgivtal lesdvnialv sklrnnirsq 61 llsenrseks ttnaqtkkli qktvfdelck lvtcegseek afvpkkrktn iimfvglqgs 121 gkttsctkla vyyskrgfkv glvcadtfra gafdqlkqna iraripfygs ytetdpakva 181 eeginkfkke kfdiiivdts grhhqeeelf qemieisnvi kpnqtimvld asigqaaeqq 241 skafkessdf gaiiltkmdg hargggaisa vaatntpiif igtgehihdl ekfspksfis 301 kllgigdies lfeqlqtvsn kedakatmen iqkgkftlld fkkqmqtimk mgplsniaqm 361 ipgmsnmmnq vgeeetsqkm kkmvyvldsm tkeelesdgr mfieeptrmv rvakgsgtsv 421 fevemilmqq qmmarmaqta tqqqpgapga narmpgmpnm pgmpnmpgmp nmpgmpkvtp 481 qmmqqaqqkl kqnpglmqnm mnmfgggmgg gmgggmpdmn emmkmmqdpq mqqmakqfgm 541 g // LOCUS NP_015414 888 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR089W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015414 VERSION NP_015414.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184186.1 REFERENCE 1 (residues 1 to 888) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 888) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 888) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 888) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 888) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11506. On Oct 2, 2003 this sequence version replaced NP_015414.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..888 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..888 /product="uncharacterized protein" /calculated_mol_wt="102448" Region 67..152 /region_name="Ank_2" /note="Ankyrin repeats (3 copies); pfam12796" /db_xref="CDD:463710" Region 275..776 /region_name="Myo5p-like_CBD_DIL_ANK" /note="cargo binding domain of myosin 5-like of dil and ankyrin domain containing protein; cd15473" /db_xref="CDD:271257" CDS 1..888 /locus_tag="YPR089W" /gene_synonym="YPR090W" /coded_by="NM_001184186.1:1..2667" /note="hypothetical protein; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p" /db_xref="GeneID:856204" /db_xref="SGD:S000006293" ORIGIN 1 mnsvwddari edrtvdkpvg sshaqeklal vkstlfkldq edrpecdswv qlvklicded 61 reeefttfke llrevknvnd ksvtgvalih yiivfdrady iellhdnpsg akldlnlvdd 121 ivgytplmws fslqrrnccl elfnafdein fnmtnkaglt awdmvppysp lsefleqnnm 181 fryrtevkhe ipqisqpkdt sllmsnedst tketfdnidl qvagltlspg andnmfldsd 241 eknmnhsqga atlidptyte dyhgtfdydk lspdqylefs dfdipqilnl lislpqkeph 301 mttypagliy qciryadhki kskplvesli nlsltkilts vssngaaglv steaslqagd 361 ivlqsywlsc lsflyyylcr ddsffkrhps vlqelintih siiieltssi hcrlislids 421 tllayttiqd vkqtlykrdw nffkkrkqak lllkeknrkq lkeqqkkelh rksqgqenhe 481 eeegqqdgnd sddrastndd nnssvslfyd keilrhlypp sfeeqmkpsp lkivqifgal 541 syvlnlhqth pifqqqclsi svnwfattlf nkilkdkkkr slsrahaiqi rlnlstlesw 601 iqnndfcvpk pmliddfmwq rfpmtlirdv geidlsdpil rnvatykpid ennkdliydt 661 snslfyyqpf hkiaqihlep vfqllqwlqv attldseesl istmnllpri tpvqllksme 721 kynyelnenk fnsklkkfln nkikdskmsk adaylqehei pylvlptipe mtdlyskgpd 781 shsfqpflpg siqddvyeih dvnfkqrqne pqisrtnsgt sdftgdedka qyetegvges 841 idinetvepe snafnvgndd yfkelnipss taqrpawsnn ddmeqnpw // LOCUS NP_015416 770 aa linear PLN 30-JUN-2025 DEFINITION Nvj2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015416 VERSION NP_015416.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184188.1 REFERENCE 1 (residues 1 to 770) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 770) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 770) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 770) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 770) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11507. Method: conceptual translation. FEATURES Location/Qualifiers source 1..770 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..770 /product="Nvj2p" /calculated_mol_wt="87193" Region 129..264 /region_name="PH-like" /note="Pleckstrin homology-like domain; cl17171" /db_xref="CDD:473070" Region 310..495 /region_name="SMP_TEX2" /note="synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in testis-expressed protein 2 (TEX2) and similar proteins; cd21675" /db_xref="CDD:439231" Site order(328,331..332,336,340,359,364,386,392,394,396,422,424, 428,430,440,442,444,454,476,479..480,487,489..492) /site_type="other" /note="putative lipid binding site [chemical binding]" /db_xref="CDD:439231" CDS 1..770 /gene="NVJ2" /locus_tag="YPR091C" /coded_by="NM_001184188.1:1..2313" /experiment="EXISTENCE:direct assay:GO:0005319 lipid transporter activity [PMID:28011845]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0008289 lipid binding [PMID:22250200]" /experiment="EXISTENCE:direct assay:GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane [PMID:28011845]" /experiment="EXISTENCE:direct assay:GO:0071561 nucleus-vacuole junction [PMID:22250200]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0035621 ER to Golgi ceramide transport [PMID:28011845]" /note="Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); involved in nonvesicular transfer of ceramides from ER to Golgi during ER stress; may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial-lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments" /db_xref="GeneID:856207" /db_xref="SGD:S000006295" ORIGIN 1 maslkvflav yllggitflp lvlftlykih llysnlksas kkeldhdtad eidektrlla 61 rdidpefkar kleeqlgvkv fnkgwitvtk qyyyhsseva vilknsnnnk dsdtalqeqi 121 lqrtdlkkkq rffavlrhgn lflykddsqn anlvhaislq nrfitiwprf delgkeelpd 181 aslftkrtci aifkndlvsi dsknhnvilp hfdpltsaes nngdistndt theyqsqfhs 241 snqfflyfdn nmdkedwyyq linasknsns lstglldpnv sanaahlktk dmlqliqdin 301 stenqlttkw lnallgrlfl slqqtdtlnk fihekickkl nkiktpgfld dlvvekvdvg 361 dsaplftspe llelspegst kiaidvqyrg nltiiiatka sinlgsrfkq revslqlsik 421 ikefsgpllf likpppsnri wyafrtepim dfeiepivss sklsynvvtn aikskfaeav 481 keslvvpfmd divfyptpne vyrggiweeq dpeaaarart aaaasdmnnt sakehlealq 541 eggmktqsri kkalrperkk enlkdlvdas gvatktttqt tvttatnddv sssenstksr 601 kyfknsikki grwykdnvgn ssdtedmdei dvqdkkndds aderesdnpi ltsnpkmisn 661 rrpvprrpsq plntlspkle grkekdtenf pvppsasnmn askmfanken rkfsvssnds 721 qnslkngdph vkasklessq afvkktsqnr fndgffkqdl efeeqrepkl // LOCUS NP_015418 288 aa linear PLN 30-JUN-2025 DEFINITION ubiquitin-protein ligase ASR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015418 VERSION NP_015418.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184190.1 REFERENCE 1 (residues 1 to 288) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 288) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 288) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 288) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 288) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11508. On Oct 2, 2003 this sequence version replaced NP_015418.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..288 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..288 /product="ubiquitin-protein ligase ASR1" /calculated_mol_wt="33216" Region 1..56 /region_name="RING-H2_ASR1" /note="RING finger, H2 subclass, found in Saccharomyces cerevisiae alcohol-sensitive RING finger protein 1 (ASR1) and similar proteins; cd23120" /db_xref="CDD:438482" Region 121..167 /region_name="PHD" /note="PHD zinc finger; smart00249" /db_xref="CDD:214584" CDS 1..288 /gene="ASR1" /locus_tag="YPR093C" /coded_by="NM_001184190.1:1..867" /experiment="EXISTENCE:direct assay:GO:0004842 ubiquitin-protein transferase activity [PMID:19064926]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15117954]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15117954]" /experiment="EXISTENCE:direct assay:GO:0016567 protein ubiquitination [PMID:19064926]" /experiment="EXISTENCE:mutant phenotype:GO:0000921 septin ring assembly [PMID:25646695]" /experiment="EXISTENCE:mutant phenotype:GO:0016567 protein ubiquitination [PMID:19064926]" /experiment="EXISTENCE:mutant phenotype:GO:0045471 response to ethanol [PMID:15117954]" /note="Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; has a role in organization of septins and the actin cytoskeleton; contains a Ring/PHD finger domain similar to the mammalian rA9 protein" /db_xref="GeneID:856208" /db_xref="SGD:S000006297" ORIGIN 1 meecpiclad dqegeqfgcl nvcghkfhln cirewhkysi nlkcpicrve sthlevgegq 61 halsinlkmg fmiknaidyv gaettnerne ddtgeqdqei eflserlrgt lvmdtikiiq 121 csicgdtdvs rlslycqdce aiyhetclrg lacevgdrnt wqectdcrsn allelrmgai 181 ssqlasydsr nsmifagelr dkhsvktqqm yeqirnakhk iqmhvrrald ryplpllrfk 241 daykhvnkqv srklyrlsdn kylpdqydyd slartgvhte lliychde // LOCUS NP_015419 107 aa linear PLN 30-JUN-2025 DEFINITION U2 snRNP complex subunit RDS3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015419 VERSION NP_015419.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184191.1 REFERENCE 1 (residues 1 to 107) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 107) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 107) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 107) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 107) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11509. Method: conceptual translation. FEATURES Location/Qualifiers source 1..107 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..107 /product="U2 snRNP complex subunit RDS3" /calculated_mol_wt="12129" Region 1..105 /region_name="PHF5" /note="PHF5-like protein; pfam03660" /db_xref="CDD:461008" CDS 1..107 /gene="RDS3" /locus_tag="YPR094W" /coded_by="NM_001184191.1:1..324" /experiment="EXISTENCE:direct assay:GO:0000245 spliceosomal complex assembly [PMID:14517302]" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:15565172|PMID:16314500]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:12871902]" /experiment="EXISTENCE:mutant phenotype:GO:0000245 spliceosomal complex assembly [PMID:14517302]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:12871902]" /experiment="EXISTENCE:mutant phenotype:GO:0009410 response to xenobiotic stimulus [PMID:11943786]" /experiment="EXISTENCE:physical interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:16314500]" /note="Component of the SF3b subcomplex of the U2 snRNP; zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance" /db_xref="GeneID:856209" /db_xref="SGD:S000006298" ORIGIN 1 msrhqfdlim clkqpgvqtg llcekcdgkc picdsyvrpk rkvrvcencs fgkqakncii 61 cnlnvgvnda fycweccrlg kdkdgcpril nlgsnrldrh fekkkkv // LOCUS NP_015420 1226 aa linear PLN 30-JUN-2025 DEFINITION Arf family guanine nucleotide exchange factor SYT1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015420 VERSION NP_015420.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184192.1 REFERENCE 1 (residues 1 to 1226) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1226) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1226) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1226) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1226) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11510. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1226 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1226 /product="Arf family guanine nucleotide exchange factor SYT1" /calculated_mol_wt="137452" Region 443..622 /region_name="Sec7" /note="Sec7 domain; smart00222" /db_xref="CDD:214569" Site order(519..526,564..577) /site_type="active" /note="active site/putative ARF binding site [active]" /db_xref="CDD:238100" CDS 1..1226 /gene="SYT1" /locus_tag="YPR095C" /coded_by="NM_001184192.1:1..3681" /experiment="EXISTENCE:direct assay:GO:0000139 Golgi membrane [PMID:20841378]" /experiment="EXISTENCE:direct assay:GO:0005085 guanyl-nucleotide exchange factor activity [PMID:10430582]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0032014 positive regulation of ARF protein signal transduction [PMID:20841378]" /experiment="EXISTENCE:genetic interaction:GO:0006887 exocytosis [PMID:10430582]" /experiment="EXISTENCE:mutant phenotype:GO:0016192 vesicle-mediated transport [PMID:10430582]" /experiment="EXISTENCE:mutant phenotype:GO:0032014 positive regulation of ARF protein signal transduction [PMID:20841378]" /experiment="EXISTENCE:mutant phenotype:GO:0034067 protein localization to Golgi apparatus [PMID:26966233]" /experiment="EXISTENCE:mutant phenotype:GO:0034976 response to endoplasmic reticulum stress [PMID:26966233]" /note="Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain" /db_xref="GeneID:856210" /db_xref="SGD:S000006299" ORIGIN 1 mnqsisslik lkflqshsnd kngnkkggsn vstgidklre sesyrspflq laeiqehtnn 61 dddkldvkec eptkkhskls rirrkmgrld lnfrsanekg seddeilvaq hlrngqdpee 121 mpfksennid siekvpkpdg ervtltssgs dnvkrnskha pfipvkpale kfpssnrlsr 181 dyrksqeptl fngdrlvptl ptvsristss svgsstaasr yfnpskravv assssssssi 241 kfnslhaipl datpqielak qqdeiskrrf grrrsrtvdv fdyinknnta knkpplspss 301 firtideknt nslmqdpmgs rgpllpddan iisndtdgae ashpdhqvls rsrsqstsfv 361 qgkggkrksi edegyhnklg lphgsgptsv ynnksnanst itgmsrrsss ivnalssfvn 421 lrssslsssr qqhlqqqqql qqkldvsled lppvpapefs dsckdflikl apygkfigii 481 ltekddefkk nclnylltnc fefkndpldi alrkllmfle lpketqqidr limafsfayy 541 kaqksyskkk giecpwsnad qvyfiafsll mlhtdyfnpn nkskmtkhdf vdlvhndkys 601 ggneipmavl tyfyenvtak espkfnyflm spmalddsil dkdafdtnfa itlssnsmys 661 pidmikrgsi ipkeaslspi fypltnsisa sgiapstaas cppstsgtin ganlgtansn 721 snrpasnsis syfsynpsss ssgnatlvqd dinvyshiin dtlnevnlfp evskywnkna 781 lkanllrnee hkyekyysim ndtkggylrf hksqlnklnl pnfeilndns rsgcknsdyk 841 yckilqmgai mnlgmpsrkf sivnsakihw kkefailtsl gllicdkmdw inpqmmkdpk 901 sgttnyiidf ksgfsfvpgs tidvynglfa drerdslgks hfaslvlayt ehhstgshts 961 nttaasssak hnegvfepss deedsitnst dgtssvsnge sdndsvsssd nqlssndsne 1021 dyhsikdeyp ifedenadcl lylhtchrnf iwkcankyer dnwidsinlf saydgcyvei 1081 gsianticnk rkltilqrme rlrsiksakw eklkkfestl mlmgkcvpis tktktdminr 1141 irqlavrmdw liyeikrsel fvsiikevtr kqaeknileh gkgeeegqgn nddsdgiddi 1201 eesflfnens lqvcvsdssy deysne // LOCUS NP_015421 100 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR096C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015421 VERSION NP_015421.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184193.1 REFERENCE 1 (residues 1 to 100) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 100) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 100) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 100) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 100) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11511. Method: conceptual translation. FEATURES Location/Qualifiers source 1..100 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..100 /product="uncharacterized protein" /calculated_mol_wt="11673" CDS 1..100 /locus_tag="YPR096C" /coded_by="NM_001184193.1:1..303" /experiment="EXISTENCE:mutant phenotype:GO:0045727 positive regulation of translation [PMID:32639961]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments" /db_xref="GeneID:856211" /db_xref="SGD:S000006300" ORIGIN 1 mrgetgvsik nprpsrpfsc fwrkgdveni rksdignekk idakfnrlqy nlyykplshh 61 kagllykelf frscfsyttc sldfqgkrhq verkavdivl // LOCUS NP_015422 1073 aa linear PLN 30-JUN-2025 DEFINITION Lec1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015422 VERSION NP_015422.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184194.2 REFERENCE 1 (residues 1 to 1073) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1073) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1073) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1073) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1073) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1073) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1073) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11512. On Apr 26, 2011 this sequence version replaced NP_015422.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1073 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1073 /product="Lec1p" /calculated_mol_wt="122953" Region 6..149 /region_name="PXB" /note="PX-associated; pfam12828" /db_xref="CDD:432813" Region 201..502 /region_name="PX_UP2_fungi" /note="The phosphoinositide binding Phox Homology domain of uncharacterized fungal proteins; cd06869" /db_xref="CDD:132779" Site order(329..331,355..356,472) /site_type="other" /note="putative phosphoinositide binding site [chemical binding]" /db_xref="CDD:132779" Region 570..917 /region_name="DUF3818" /note="Domain of unknown function in PX-proteins (DUF3818); pfam12825" /db_xref="CDD:463720" CDS 1..1073 /gene="LEC1" /locus_tag="YPR097W" /coded_by="NM_001184194.2:1..3222" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0035091 phosphatidylinositol binding [PMID:11557775]" /note="Phosphoinositide-binding regulator of ergosterol distribution; contains PX (Phox homology) domain; associated with ER-lipid droplet contact site; may facilitate ergosterol transport between plasma membrane and lipid droplets" /db_xref="GeneID:856212" /db_xref="SGD:S000006301" ORIGIN 1 mitqdtpaln pteehylkre llrcqldyei gklndqfalr kfgypfspnd ptapqpisnn 61 dsspvlggkg hfsvnypmls yvlqefistf pllstnllvd ekfwqskvqv ffehfmslgf 121 sesydreeas krkkvskkls kvilllfnsg vgsfqeqayy nedkfvlqsg qarkrsniek 181 famptrenle nlltnesvfi ngwdvniisv fnknsrkcte svdndkssks tptsspksha 241 iksfastskw mknafnntin stinsmpess aslfsklslg vpstkskqsr khhyflikik 301 kqddddqdns neensnldhh agyfyvtrty sdfkklshdl ksefpgkkcp rlphrnkkvt 361 smitktevlh ngqtksaare kivntfdtdl qsasesdnss flqttnelsa tetvlteket 421 etlrknilne ikeednided eyeeegegee sdfdeykdas dskintlvge kmrtslrqyl 481 rtlckdaevs qsssirrffl sgpnldikdi npkiaddirn ralidvsnle nqirfqqmal 541 ekslklqdsm kdfktsllkd ekylmsllve ikdntkvedl spllqdfvew ckiyissmiy 601 qmflgndnsy elytqirrlh klmpytvmgq imkftnpiai mrgmielfma qpfgghsllq 661 tmfstiltdd lktqkvaike lerkiaemdp gasvvtkclk dfvfnndtkd ehdtklftmd 721 avnaesesmn mpvplivlmk saaanlipde vvagliesys swklqkedtd alnvtsedqs 781 giyfthvkdl wqlyikehdk qlmrqlwqdp eltqmlkaiv tmiyepmvki fkvarmdval 841 knfekfmsdl irlvddving qlgvstqfdv veeihnlvtk hqdaffefih dvylndsegi 901 fegfitwitt ivkflqkskf ggpseridfn klicrddidi dvkllkvqvn nvlnkkigar 961 kiykklldlk vkqgtkqnnk haagilqknw sdinslvmps ssgsfglgdg dlvdldldtg 1021 dydflhkene velekqykdl lnlvvdesei dklrsqvfaq elknyleaqi akk // LOCUS NP_015423 161 aa linear PLN 30-JUN-2025 DEFINITION Tmh18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015423 VERSION NP_015423.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184195.1 REFERENCE 1 (residues 1 to 161) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 161) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 161) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 161) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 161) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11513. On Oct 2, 2003 this sequence version replaced NP_015423.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..161 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..161 /product="Tmh18p" /calculated_mol_wt="17600" Region 11..105 /region_name="DUF4149" /note="Domain of unknown function (DUF4149); pfam13664" /db_xref="CDD:463949" CDS 1..161 /gene="TMH18" /locus_tag="YPR098C" /coded_by="NM_001184195.1:1..486" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /note="Mitochondrial hypothetical protein; localized to the mitochondrial outer membrane" /db_xref="GeneID:856213" /db_xref="SGD:S000006302" ORIGIN 1 mclvkttahl lfysfvfggt tfysyvaspi afkvlekdqf salqnkifpy ffqmqaaspv 61 ilaltapial ttgplsslvv asvsgltnlf wllpwthkvk eqrkniakky tgseleakda 121 ilrkefgksh glsllfnlsn vcgmlaygvc lsggllrkip k // LOCUS NP_001374312 118 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR099C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001374312 VERSION NP_001374312.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001387383.1 REFERENCE 1 (residues 1 to 118) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 118) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 118) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 118) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 118) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAC85312. Method: conceptual translation. FEATURES Location/Qualifiers source 1..118 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..118 /product="uncharacterized protein" /calculated_mol_wt="13229" CDS 1..118 /locus_tag="YPR099C" /coded_by="NM_001387383.1:1..357" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31374566]" /note="Mitochondrial hypothetical protein; null mutant has a respiratory growth defect and displays reduced peroxide-induced mitochondrial ROS; partially overlaps the verified gene MRPL51/YPR100W" /db_xref="GeneID:856215" /db_xref="SGD:S000006303" ORIGIN 1 mspsesfnsf slfstlsmfk fltqitfsrp fvysalnkgc pdflitsnci hgnswphlsn 61 lfevknflmp sedppqlqnc kviflhgntn aptplrpmef raiafttisp yirvcvst // LOCUS NP_015425 140 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 54S ribosomal protein mL43 MRPL51 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015425 VERSION NP_015425.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184197.1 REFERENCE 1 (residues 1 to 140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 140) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11514. Method: conceptual translation. FEATURES Location/Qualifiers source 1..140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..140 /product="mitochondrial 54S ribosomal protein mL43 MRPL51" /calculated_mol_wt="15993" Region 35..104 /region_name="L51_S25_CI-B8" /note="Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain; smart00916" /db_xref="CDD:197984" CDS 1..140 /gene="MRPL51" /locus_tag="YPR100W" /gene_synonym="mL43" /coded_by="NM_001184197.1:1..423" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:12392552]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:31374566|PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005762 mitochondrial large ribosomal subunit [PMID:12392552]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:31374566]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:31374566]" /note="Mitochondrial ribosomal protein of the large subunit; required for mitochondrial genome integrity, respiratory growth, and mitochondrial redox homeostasis, partially overlaps verified gene YPR099C" /db_xref="GeneID:856214" /db_xref="SGD:S000006304" ORIGIN 1 mvvkaiarns igrngvgafv fpcrkitlqf cnwggssegm rkfltskrld kwgqefpwiq 61 fevmrksghp llraeytngr ekvicvrnln idnvenklkl lkdsdgdilr rrtkndnves 121 lnssvrgiws plhaakrhri // LOCUS NP_015426 175 aa linear PLN 30-JUN-2025 DEFINITION Snt309p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015426 VERSION NP_015426.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184198.1 REFERENCE 1 (residues 1 to 175) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 175) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 175) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 175) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 175) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11515. Method: conceptual translation. FEATURES Location/Qualifiers source 1..175 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..175 /product="Snt309p" /calculated_mol_wt="20578" CDS 1..175 /gene="SNT309" /locus_tag="YPR101W" /gene_synonym="NTC25" /coded_by="NM_001184198.1:1..528" /experiment="EXISTENCE:curator inference:GO:0000384 first spliceosomal transesterification activity [PMID:9528791]" /experiment="EXISTENCE:direct assay:GO:0000974 Prp19 complex [PMID:9528791]" /experiment="EXISTENCE:direct assay:GO:0071006 U2-type catalytic step 1 spliceosome [PMID:9528791]" /experiment="EXISTENCE:genetic interaction:GO:0000398 mRNA splicing, via spliceosome [PMID:9528791]" /experiment="EXISTENCE:mutant phenotype:GO:0000398 mRNA splicing, via spliceosome [PMID:9528791]" /note="Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p" /db_xref="GeneID:856216" /db_xref="SGD:S000006305" ORIGIN 1 mdglsfvdkg kipdgyknei dqlvkkefan ikrepvhpei rgilakrkga dnsvstltna 61 lyteylkqrn nkkrrtpdfn ddddtlflee yrrkypridt sryipnesse vsllgivdsy 121 lkhqeivldt llpqtvsnqw rinndyirqt ctiveemniq qrkqindlei yrkrl // LOCUS NP_015427 174 aa linear PLN 30-JUN-2025 DEFINITION 60S ribosomal protein uL5 RPL11A [Saccharomyces cerevisiae S288C]. ACCESSION NP_015427 VERSION NP_015427.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184199.1 REFERENCE 1 (residues 1 to 174) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 174) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 174) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 174) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 174) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11516. Method: conceptual translation. FEATURES Location/Qualifiers source 1..174 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..174 /product="60S ribosomal protein uL5 RPL11A" /calculated_mol_wt="19589" Region 2..172 /region_name="PTZ00156" /note="60S ribosomal protein L11; Provisional" /db_xref="CDD:185485" CDS 1..174 /gene="RPL11A" /locus_tag="YPR102C" /coded_by="NM_001184199.1:1..525" /experiment="EXISTENCE:curator inference:GO:0002181 cytoplasmic translation [PMID:11983894]" /experiment="EXISTENCE:curator inference:GO:0003735 structural constituent of ribosome [PMID:11983894]" /experiment="EXISTENCE:direct assay:GO:0022625 cytosolic large ribosomal subunit [PMID:11983894]" /experiment="EXISTENCE:mutant phenotype:GO:0000027 ribosomal large subunit assembly [PMID:2277060]" /note="Ribosomal 60S subunit protein L11A; expressed at twice the level of Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; homologous to mammalian ribosomal protein L11 and bacterial L5; RPL11A has a paralog, RPL11B, that arose from the whole genome duplication" /db_xref="GeneID:856217" /db_xref="SGD:S000006306" ORIGIN 1 msakaqnpmr dlkieklvln isvgesgdrl traskvleql sgqtpvqska rytvrtfgir 61 rnekiavhvt vrgpkaeeil erglkvkeyq lrdrnfsatg nfgfgidehi dlgikydpsi 121 gifgmdfyvv mnrpgarvtr rkrckgtvgn shkttkedtv swfkqkydad vldk // LOCUS NP_015428 287 aa linear PLN 30-JUN-2025 DEFINITION proteasome core particle subunit beta 5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015428 VERSION NP_015428.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184200.1 REFERENCE 1 (residues 1 to 287) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 287) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 287) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 287) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 287) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11517. Method: conceptual translation. FEATURES Location/Qualifiers source 1..287 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..287 /product="proteasome core particle subunit beta 5" /EC_number="3.4.25.1" /calculated_mol_wt="31506" Region 76..264 /region_name="proteasome_beta_type_5" /note="proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; cd03761" /db_xref="CDD:239730" Site order(76,92,94,108,206,243,246..247) /site_type="active" /db_xref="CDD:239730" Site order(94,97,99..104,124,126,141,153,156..157,159..160,163, 166,191,193,195..198,201,209..210,212..213,216..218,234, 241..244,247..248) /site_type="other" /note="beta subunit interaction site [polypeptide binding]" /db_xref="CDD:239730" CDS 1..287 /gene="PRE2" /locus_tag="YPR103W" /gene_synonym="DOA3; PRG1; SRR2" /coded_by="NM_001184200.1:1..864" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:36164978]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0010499 proteasomal ubiquitin-independent protein catabolic process [PMID:19162040]" /experiment="EXISTENCE:direct assay:GO:0019774 proteasome core complex, beta-subunit complex [PMID:9087403]" /experiment="EXISTENCE:direct assay:GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process [PMID:11545745|PMID:19029916]" /experiment="EXISTENCE:mutant phenotype:GO:0004175 endopeptidase activity [PMID:8808631|PMID:9312134]" /experiment="EXISTENCE:mutant phenotype:GO:0080129 proteasome core complex assembly [PMID:8808631]" /note="Beta 5 subunit of the 20S proteasome; responsible for the chymotryptic activity of the proteasome; localizes to peroxisomes in oleate-growing cells" /db_xref="GeneID:856218" /db_xref="SGD:S000006307" ORIGIN 1 mqaiadsfsv pnrlvkelqy dneqnlesdf vtgasqfqrl apsltvppia spqqflraht 61 ddsrnpdcki kiahgtttla frfqggiiva vdsratagnw vasqtvkkvi einpfllgtm 121 aggaadcqfw etwlgsqcrl helrekeris vaaaskilsn lvyqykgagl smgtmicgyt 181 rkegptiyyv dsdgtrlkgd ifcvgsgqtf aygvldsnyk wdlsvedaly lgkrsilaaa 241 hrdaysggsv nlyhvtedgw iyhgnhdvge lfwkvkeeeg sfnnvig // LOCUS NP_015429 936 aa linear PLN 30-JUN-2025 DEFINITION Fhl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015429 VERSION NP_015429.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184201.1 REFERENCE 1 (residues 1 to 936) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 936) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 936) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 936) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 936) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 936) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 936) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11518. Method: conceptual translation. FEATURES Location/Qualifiers source 1..936 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..936 /product="Fhl1p" /calculated_mol_wt="103372" Region 18..739 /region_name="COG5025" /note="Transcription factor of the Forkhead/HNF3 family [Transcription]" /db_xref="CDD:227358" CDS 1..936 /gene="FHL1" /locus_tag="YPR104C" /gene_synonym="SPP42" /coded_by="NM_001184201.1:1..2811" /experiment="EXISTENCE:direct assay:GO:0000785 chromatin [PMID:15620355|PMID:15692568]" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:27016735]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15466158]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:15466158]" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19158363|PMID:19111667]" /experiment="EXISTENCE:genetic interaction:GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:7785326]" /experiment="EXISTENCE:genetic interaction:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15616569]" /experiment="EXISTENCE:mutant phenotype:GO:0010688 negative regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15620355]" /experiment="EXISTENCE:mutant phenotype:GO:0060963 positive regulation of ribosomal protein gene transcription by RNA polymerase II [PMID:15620355|PMID:15616569]" /experiment="EXISTENCE:physical interaction:GO:0001222 transcription corepressor binding [PMID:15620355]" /experiment="EXISTENCE:physical interaction:GO:0001223 transcription coactivator binding [PMID:15620355]" /note="Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants" /db_xref="GeneID:856219" /db_xref="SGD:S000006308" ORIGIN 1 mdgemaiies snhvgtsspt tetqftidss alkdqetkes itnsptsevp ietklpkssd 61 ivteekhpqn tttdieneve npvtddngnl klelpdnldn adfskllefd akndealfns 121 nellshtmdp vnnidlthdh srevsskedi niepvnpded erektqdnta avktegirns 181 edtsiqkdep tadaiytdvh klsvnkdtet lptlvdeknn mlhmrnnsit pimfqqhelv 241 gqppqntvte nnstdaettq rklsepidas lplpneqpti fayarldfqs ftfyvqtlha 301 iigrrsendf shkvdvnlgp sksisrrhaq ifynfgtgrf elsiigknga fvddifvekg 361 ntvplrnktk iqigqipfqf ilpeqerndd skspenadia eseintrnlk knepkskkki 421 ttgakpkkaq tkpavkkekk ppkipkkvyt leeipveyrt kptvsysaml ttcirkysta 481 kgmslseiya girelfpyyk ycpdgwqssv rhnlslnksf rkvskegkgw lwgldeeyia 541 ererqkkkqs eiavakaqaa qlkleqqqhk lqqvpqrgkk divsqrsnvn arkqnisqtl 601 aanraasnrk ntasdnqrtm kylqeqlvil trdrkglskq viaailtqal amtinqvtqa 661 aknkgitgnp ltalmdknpq hlnlilaaav naatakvtkg evkqlvnpet taaaalaaka 721 qhskpirqpi vqtphvpdrp psqlsasass hpnnylhdkq pgsfdpssls rffqprqnar 781 atssvaatsv paaasqnvda qpkpkpaqdn dlesesgtss ssssssesgs esdsgsddgs 841 asgsgdnsst ssesesesds gsevdeknnk nekidsesik nneskddips kdenssndnr 901 eisktdeegh dskrrkvsed inegitevnv sleekl // LOCUS NP_015430 861 aa linear PLN 30-JUN-2025 DEFINITION Golgi transport complex subunit COG4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015430 VERSION NP_015430.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184202.1 REFERENCE 1 (residues 1 to 861) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 861) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 861) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 861) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 861) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11519. Method: conceptual translation. FEATURES Location/Qualifiers source 1..861 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..861 /product="Golgi transport complex subunit COG4" /calculated_mol_wt="98535" Region 190..526 /region_name="Cog4" /note="COG4 transport protein; smart00762" /db_xref="CDD:214809" CDS 1..861 /gene="COG4" /locus_tag="YPR105C" /gene_synonym="COD1; SEC38; SGF1" /coded_by="NM_001184202.1:1..2586" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000301 retrograde transport, vesicle recycling within Golgi [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0000425 pexophagy [PMID:20065092]" /experiment="EXISTENCE:mutant phenotype:GO:0006891 intra-Golgi vesicle-mediated transport [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:20065092]" /experiment="EXISTENCE:mutant phenotype:GO:0017119 Golgi transport complex [PMID:11703943]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:20065092]" /note="Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" /db_xref="GeneID:856220" /db_xref="SGD:S000006309" ORIGIN 1 megqksnasw essiiegqls knlarytlll dklstlsqid klseviandy akqskqlnaf 61 vqqsqsslnk esrklelqrt nltttltqfh etvatisssn arakaihddi etvdqeralv 121 nktlqfvkdv rtlknnisla hsaletkdyl vaataineir slpdkklivs efakkvvpss 181 eipeepaili knwckeltsl fqeqfmeatr tqdikeltlm fkmfpmigqd vlgldlysky 241 vcdiiadesr kimsnsmens tkfqgffsqv llhlfkivst iindhskvia tcygkkhmvh 301 vmekvekead lqaslildif metrkierti hdinewehsq knedvnidsn qsdietdget 361 ekssiisihd lallimefsq ilqnwsmysr fysvkwnefs dlhphvlqpp ppiadgkfal 421 klkqdkvfde fqvfvlnhlq rsfrnsisle elpslndlit avplndhdni sypvtsvldd 481 lillvrknli svvntgqfkl lasflnelvk ffqnrflvkf mqnkfkllqs klasnvslkr 541 yipkgeeqsa tsrsvsppan kfsplsrftf rgaaasaltn iqsnlqavva ededsilalh 601 hyliylntly lskvyvhrll sieileddsq rilrdnfpfd ndaaqlqnli inseklvleq 661 tdklskwavk ylfqnilqnr vrnllgtvfv nsassnssts nqknvsrdys agsnqknyit 721 siedfedlsq insfnskwnq liipyknilh neayaellsv ivdyivttle qriwtlefne 781 lgvtkldrel slfignmcgl nynlrekflk ltqivlllgl dddnfdlttg dikddfngtf 841 dwvinsqeri karnmkidrt q // LOCUS NP_015431 443 aa linear PLN 30-JUN-2025 DEFINITION putative protein kinase ISR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015431 VERSION NP_015431.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184203.1 REFERENCE 1 (residues 1 to 443) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 443) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 443) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 443) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 443) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11520. Method: conceptual translation. FEATURES Location/Qualifiers source 1..443 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..443 /product="putative protein kinase ISR1" /EC_number="2.7.11.1" /calculated_mol_wt="49605" Region 142..372 /region_name="Protein Kinases, catalytic domain" /note="The protein kinase superfamily is mainly composed of the catalytic domains of serine/threonine-specific and tyrosine-specific protein kinases. It also includes RIO kinases, which are atypical serine protein kinases, aminoglycoside phosphotransferases; cl21453" /db_xref="CDD:473864" Site order(142..144,147,149,167,169,203,230..233,280,284..285, 287,302..303) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270870" CDS 1..443 /gene="ISR1" /locus_tag="YPR106W" /coded_by="NM_001184203.1:1..1332" /experiment="EXISTENCE:genetic interaction:GO:0018105 peptidyl-serine phosphorylation [PMID:32579556]" /experiment="EXISTENCE:genetic interaction:GO:0018107 peptidyl-threonine phosphorylation [PMID:32579556]" /experiment="EXISTENCE:genetic interaction:GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process [PMID:32579556]" /experiment="EXISTENCE:mutant phenotype:GO:0018105 peptidyl-serine phosphorylation [PMID:32579556]" /experiment="EXISTENCE:mutant phenotype:GO:0018107 peptidyl-threonine phosphorylation [PMID:32579556]" /experiment="EXISTENCE:mutant phenotype:GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process [PMID:32579556]" /note="Predicted protein kinase; negatively regulates the hexosamine biosynthetic pathway (HBP), which converts fructose-6-phosphate into UDP-N-acetylglucosamine, a precursor of chitin biosynthesis, GPI-anchor formation and glycosylation; interacts genetically with GFA1, encoding the first enzyme in the HBP; involved in Gfa1p phosphorylation (S332, T334); contains a Pho85p-regulated SCF-CDC4 phosphodegron; unstable, cell cycle regulated protein, peaking at G1/S" /db_xref="GeneID:856221" /db_xref="SGD:S000006310" ORIGIN 1 mnstpptspv trvsdgsfps isnnskgfay rqpqkhksnf ayshlvspve eptakfseaf 61 qtdysskapv atseahlknd ldvlfttprf yspenlalmf rlsntvssle fldeflmgil 121 lapemdflsn psyslpsnkl vgqgsysyvy pisssassrc nndsgvvlkf aksqhkskvi 181 lqealtlayl qymspstnes hiipfyglty itkshfrrlr snecvpglil pkcemslyhf 241 ntavshklsl itkrkiwwrl mkqmidalks lktngiihgd iktanilite mhvlngghck 301 dfdfyladft safhinqtpt dlnttveyca pelidsssdh vptfesdlya vglcllsfis 361 qhepynelqa lvshgsspgi gsssiqqsqw linallkkdp inlnmlrndl fqdwkselal 421 lsrilvdrlp lenlitilds nyi // LOCUS NP_015432 208 aa linear PLN 30-JUN-2025 DEFINITION cleavage polyadenylation factor RNA-binding subunit YTH1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015432 VERSION NP_015432.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184204.1 REFERENCE 1 (residues 1 to 208) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 208) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 208) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 208) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11521. Method: conceptual translation. FEATURES Location/Qualifiers source 1..208 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..208 /product="cleavage polyadenylation factor RNA-binding subunit YTH1" /calculated_mol_wt="24422" Region 2..208 /region_name="YTH1" /note="Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]; COG5084" /db_xref="CDD:227416" CDS 1..208 /gene="YTH1" /locus_tag="YPR107C" /coded_by="NM_001184204.1:1..627" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:9224719]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005847 mRNA cleavage and polyadenylation specificity factor complex [PMID:12819204]" /experiment="EXISTENCE:direct assay:GO:0006397 mRNA processing [PMID:11344258]" /experiment="EXISTENCE:mutant phenotype:GO:0006397 mRNA processing [PMID:10899131]" /note="Essential RNA-binding component of cleavage and polyadenylation factor; contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:856222" /db_xref="SGD:S000006311" ORIGIN 1 mslihpdtak ypfkfepflr qeysfsldpd rpicefynsr egpkscprgp lcpkkhvlpi 61 fqnkivcrhw lrglckkndq ceylheynlr kmpecvffsk ngyctqspdc qylhidpask 121 ipkcenyemg fcplgsscpr rhikkvfcqr ymtgfcplgk decdmehpqf iipdegsklr 181 ikrddeintr kmdeekerrl naiingev // LOCUS NP_015433 429 aa linear PLN 30-JUN-2025 DEFINITION proteasome regulatory particle lid subunit RPN7 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015433 VERSION NP_015433.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184205.1 REFERENCE 1 (residues 1 to 429) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 429) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 429) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 429) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11522. Method: conceptual translation. FEATURES Location/Qualifiers source 1..429 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..429 /product="proteasome regulatory particle lid subunit RPN7" /calculated_mol_wt="48828" Region 2..429 /region_name="RPN7" /note="26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]; COG5187" /db_xref="CDD:227514" CDS 1..429 /gene="RPN7" /locus_tag="YPR108W" /coded_by="NM_001184205.1:1..1290" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:19446323]" /experiment="EXISTENCE:direct assay:GO:0008541 proteasome regulatory particle, lid subcomplex [PMID:9741626]" /experiment="EXISTENCE:mutant phenotype:GO:0005198 structural molecule activity [PMID:15102831]" /note="Essential non-ATPase regulatory subunit of the 26S proteasome; similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits" /db_xref="GeneID:856223" /db_xref="SGD:S000006312" ORIGIN 1 mvdveeksqe veyvdptvnr vpnyevseka flltqskvsi eqrkeaaefv lakikeeema 61 pyykylceey lvnngqsdle hdeksdslne wikfdqelyn elckkneski kelnekiqkl 121 eeddegeleq aqawinlgey yaqigdkdna ektlgkslsk aistgakidv mltiarlgff 181 yndqlyvkek leavnsmiek ggdwerrnry ktyygihcla vrnfkeaakl lvdslatfts 241 ieltsyesia tyasvtglft lertdlkskv idspellsli sttaalqsis sltislyasd 301 yasyfpylle tyanvlipck ylnrhadffv remrrkvyaq llesyktlsl ksmasafgvs 361 vafldndlgk fipnkqlncv idrvngivet nrpdnknaqy hllvkqgdgl ltklqkygaa 421 vrltgsdrv // LOCUS NP_015434 294 aa linear PLN 30-JUN-2025 DEFINITION Gld1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015434 VERSION NP_015434.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184206.1 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11524. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..294 /product="Gld1p" /calculated_mol_wt="32579" Region 34..230 /region_name="DUF1746" /note="Fungal domain of unknown function (DUF1746); pfam08508" /db_xref="CDD:430039" CDS 1..294 /gene="GLD1" /locus_tag="YPR109W" /coded_by="NM_001184206.1:1..885" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:29355480]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005802 trans-Golgi network [PMID:29355480]" /experiment="EXISTENCE:direct assay:GO:0044695 Dsc E3 ubiquitin ligase complex [PMID:29355480]" /experiment="EXISTENCE:mutant phenotype:GO:0031503 protein-containing complex localization [PMID:29355480]" /experiment="EXISTENCE:mutant phenotype:GO:0051668 localization within membrane [PMID:29355480]" /experiment="EXISTENCE:mutant phenotype:GO:0140624 EGAD pathway [PMID:31368600]" /note="Trafficking adaptor for the Dsc E3 ligase complex; component of a Dsc subcomplex that sorts the E3 ligase to the Golgi and to endosomes; involved in the endosome and Golgi-associated degradation pathway (EGAD), contributing to proteostasis and lipid homeostasis; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; diploid deletion strain has high budding index" /db_xref="GeneID:856225" /db_xref="SGD:S000006313" ORIGIN 1 mdnfestaeg nlsignkrvy elrkrnfqrn lvnnlsflgy vlisleyiky drtvwtlitr 61 aivqslissp fpsdaklrrl atlgadnntt gvatlpggrs irfpgmfgte mlynssseae 121 qqdhddtaiv smkkqirkfl fhgclslnml fiiltilfpi dffeplsgse pvddgpkntp 181 spfsnsdgll lgerrgglfl qmigerlpks nfsgnlglvm fefsilivqf tlfsltcvvl 241 adldfeeper lepvnsdgyd gsvivaripl nktmnailnd gnindnnena snsv // LOCUS NP_015435 335 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase core subunit RPC40 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015435 VERSION NP_015435.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184207.1 REFERENCE 1 (residues 1 to 335) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 335) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 335) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 335) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 335) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11525. Method: conceptual translation. FEATURES Location/Qualifiers source 1..335 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..335 /product="DNA-directed RNA polymerase core subunit RPC40" /calculated_mol_wt="37556" Region 40..330 /region_name="RNAP_I_II_AC40" /note="AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III; cd07032" /db_xref="CDD:132910" Site order(40..42,47..48,56,60,62..63,66,69,214..215,311,315, 318..319,322,328..329) /site_type="other" /note="AC40 - AC19 heterodimer interface [polypeptide binding]" /db_xref="CDD:132910" Site order(65,68..69,73,93,95..96,99..100,216..217,222..224, 226..227,229..230) /site_type="other" /note="AC40 - A135(C128) interaction site [polypeptide binding]" /db_xref="CDD:132910" Site order(80..86,94,99,215..216,218) /site_type="other" /note="AC40 - RPB12 interaction site [polypeptide binding]" /db_xref="CDD:132910" Site order(91,100,103,161,163,190..192,195,197,218,223..224,303, 305) /site_type="other" /note="AC40 - RPB10 interaction site [polypeptide binding]" /db_xref="CDD:132910" CDS 1..335 /gene="RPC40" /locus_tag="YPR110C" /gene_synonym="RPC5" /coded_by="NM_001184207.1:1..1008" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:9837969|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /note="RNA polymerase subunit AC40; common to RNA polymerase I and III; predominant determinant targeting Ty1 integration upstream of Pol III-transcribed genes" /db_xref="GeneID:856226" /db_xref="SGD:S000006314" ORIGIN 1 msnivgieyn rvtnttstdf pgfskdaene wnvekfkkdf evnissldar eanfdlinid 61 tsianafrri misevpsvaa eyvyffnnts viqdevlahr iglvplkvdp dmltwvdsnl 121 pddekftden tivlslnvkc trnpdapkgs tdpkelynna hvyardlkfe pqgrqsttfa 181 dcpvvpadpd illaklrpgq eislkahcil giggdhakfs pvstasyrll pqinilqpik 241 gesarrfqkc fppgvigide gsdeayvkda rkdtvsrevl ryeefadkvk lgrvrnhfif 301 nvesagamtp eeiffksvri lknkaeylkn cpitq // LOCUS NP_015436 564 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine-protein kinase DBF20 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015436 VERSION NP_015436.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184208.1 REFERENCE 1 (residues 1 to 564) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 564) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 564) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 564) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 564) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11526. Method: conceptual translation. FEATURES Location/Qualifiers source 1..564 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..564 /product="serine/threonine-protein kinase DBF20" /EC_number="2.7.11.1" /calculated_mol_wt="65749" Region 77..164 /region_name="MobB_Sid2p-like" /note="Mob-binding domain found in fungal Sid2p-like serine/threonine protein kinases; cd21776" /db_xref="CDD:439271" Site order(99..100,102..104,106..107,110..111,114,117,121,150, 153..155,157..158,161..162) /site_type="other" /note="putative Mob binding site [polypeptide binding]" /db_xref="CDD:439271" Region 157..539 /region_name="STKc_Sid2p_like" /note="Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; cd05600" /db_xref="CDD:270751" Site order(175..179,183,196,198,230,246..247,249,253,255,292, 294,296..297,299,309..310,313,367..372,399,405,408) /site_type="active" /db_xref="CDD:270751" Site order(175..179,183,196,198,230,247..249,253,292,294, 296..297,299,309..310) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270751" Site order(179,253,255,292,294,296,313,367..372,399,405,408) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270751" Site order(309..319,363..372) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270751" Site 532..537 /site_type="other" /note="hydrophobic motif (HM)" /db_xref="CDD:270751" CDS 1..564 /gene="DBF20" /locus_tag="YPR111W" /coded_by="NM_001184208.1:1..1695" /experiment="EXISTENCE:direct assay:GO:0004674 protein serine/threonine kinase activity [PMID:8131744]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:12937277]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12937277]" /experiment="EXISTENCE:genetic interaction:GO:0000281 mitotic cytokinesis [PMID:12937277]" /experiment="EXISTENCE:genetic interaction:GO:0010458 exit from mitosis [PMID:1916278]" /experiment="EXISTENCE:mutant phenotype:GO:0000917 division septum assembly [PMID:17005296]" /experiment="EXISTENCE:mutant phenotype:GO:0061013 regulation of mRNA catabolic process [PMID:22196726]" /note="Ser/Thr kinase involved in late nuclear division; one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; DBF20 has a paralog, DBF2, that arose from the whole genome duplication" /db_xref="GeneID:856227" /db_xref="SGD:S000006315" ORIGIN 1 mfsrsdrevd dlagnmshlg fydlnipkpt spqaqyrpar ksengrltpg lprsykpcds 61 ddqdtfknri slnhspkklp kdfherasqs ktqrvvnvcq lyfldyycdm fdyvisrrqr 121 tkqvlryleq qrsvknvsnk vlneewalyl qrehevlrkr rlkpkhkdfq iltqvgqggy 181 gqvylakkkd sdeicalkil nkkllfklne tnhvlterdi ltttrsdwlv kllyafqdpe 241 slylamefvp ggdfrtllin trilksghar fyisemfcav nalhelgyth rdlkpenfli 301 datghikltd fglaagtvsn eriesmkirl eevknlefpa ftersiedrr kiyhnmrkte 361 inyansmvgs pdymalevle gkkydftvdy wslgcmlfes lvgytpfsgs stnetyenlr 421 ywkktlrrpr tedrraafsd rtwdlitrli adpinrvrsf eqvrkmsyfa einfetlrts 481 sppfipqldd etdagyfddf tneedmakya dvfkrqnkls amvddsavds klvgftfrhr 541 dgkqgssgil yngsehsdpf stfy // LOCUS NP_015437 887 aa linear PLN 30-JUN-2025 DEFINITION RNA-binding ribosome biosynthesis protein MRD1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015437 VERSION NP_015437.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184209.1 REFERENCE 1 (residues 1 to 887) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 887) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 887) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 887) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 887) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 887) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 887) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11527. Method: conceptual translation. FEATURES Location/Qualifiers source 1..887 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..887 /product="RNA-binding ribosome biosynthesis protein MRD1" /calculated_mol_wt="100989" Region 2..92 /region_name="RRM1_RBM19_MRD1" /note="RNA recognition motif 1 (RRM1) found in RNA-binding protein 19 (RBM19), yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins; cd12315" /db_xref="CDD:409754" Region 4..>498 /region_name="PABP-1234" /note="polyadenylate binding protein, human types 1, 2, 3, 4 family; TIGR01628" /db_xref="CDD:130689" Region 343..421 /region_name="RRM2_MRD1" /note="RNA recognition motif 2 (RRM2) found in yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins; cd12566" /db_xref="CDD:409982" Region 532..603 /region_name="RRM3_MRD1" /note="RNA recognition motif 3 (RRM3) found in yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins; cd12568" /db_xref="CDD:241012" Region 663..746 /region_name="RRM4_MRD1" /note="RNA recognition motif 4 (RRM4) found in yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins; cd12319" /db_xref="CDD:409758" Region 763..837 /region_name="RRM5_MRD1" /note="RNA recognition motif 5 (RRM5) found in yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins; cd12570" /db_xref="CDD:241014" CDS 1..887 /gene="MRD1" /locus_tag="YPR112C" /coded_by="NM_001184209.1:1..2664" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:11884397]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911|PMID:23193268]" /experiment="EXISTENCE:direct assay:GO:0042134 rRNA primary transcript binding [PMID:23193268]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11884397]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11884397]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11884397]" /experiment="EXISTENCE:mutant phenotype:GO:0034462 small-subunit processome assembly [PMID:18586827]" /note="Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region" /db_xref="GeneID:856228" /db_xref="SGD:S000006316" ORIGIN 1 msriivkglp vyltddnlre hftkrlrqkh shqavngsgp dlitdvkilr drngesrrfg 61 figyrneeda fdaveyfngs fintskievs maksfadprv pqpmkekrre alkrfrekee 121 kllqeenrkk kkvdenkhsn iddeirknkq lqefmetmkp ssqvtswekv gidksiedek 181 lkreeedssv qgnsllahal alkeennkde apnlvienes ddeysalnrn rdedqedage 241 eekmisisnl kdtdiglvnd dansdekene krrnlaqdek vsdldwfkqr rvrikeseae 301 treksssyat eqnesldtkk eeqperavpq ktdeelaiek inqtgrlflr nilytskeed 361 frklfspfge leevhvaldt rtgqskgfay vlfkdsknav nayveldkqi fqgrllhilp 421 geekkshrld efdlknmplk kqkelkrkaa asrqtfswns lymnqdavlg svaaklglek 481 sqlidaenss savkqalaea hvigdvrkyf eskgvdltkf sqlkstnqrd dkvilvknfp 541 fgttreelge mflpygkler llmppagtia ivqfrdttsa raaftklsyk rfkdgiiyle 601 rgpkdcftkp aeaddlinnt sakeeenpve vkpssndlme ankdvtegss nahdedvidg 661 ptvsifiknl nfsttnqnlt drfkvftgfv vaqvktkpdp khqgktlsmg fgfvefrtke 721 qanaviaamd gtvidghkiq lklshrqasq sgntktksnk ksgkiivknl pfeatrkdvf 781 elfnsfgqlk svrvpkkfdk sargfafvef llpkeaenam dqlhgvhllg rrlvmqyaee 841 davdaeeeia rmtkkvrkqv atnemaalrn gggrkkldvd deenegf // LOCUS NP_015438 220 aa linear PLN 30-JUN-2025 DEFINITION CDP-diacylglycerol--inositol 3-phosphatidyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015438 VERSION NP_015438.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184210.1 REFERENCE 1 (residues 1 to 220) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 220) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 220) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 220) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 220) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11528. Method: conceptual translation. FEATURES Location/Qualifiers source 1..220 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..220 /product="CDP-diacylglycerol--inositol 3-phosphatidyltransferase" /EC_number="2.7.8.11" /calculated_mol_wt="24693" Region 9..>120 /region_name="PgsA" /note="Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]; COG0558" /db_xref="CDD:440324" CDS 1..220 /gene="PIS1" /locus_tag="YPR113W" /coded_by="NM_001184210.1:1..663" /experiment="EXISTENCE:direct assay:GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity [PMID:3005284]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:3005242]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:8543066]" /experiment="EXISTENCE:direct assay:GO:0006661 phosphatidylinositol biosynthetic process [PMID:3005284]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:6274497]" /experiment="EXISTENCE:mutant phenotype:GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity [PMID:6088233]" /experiment="EXISTENCE:mutant phenotype:GO:0006661 phosphatidylinositol biosynthetic process [PMID:6088233]" /note="Phosphatidylinositol synthase; required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins" /db_xref="GeneID:856229" /db_xref="SGD:S000006317" ORIGIN 1 mssnstpekv taehvlwyip nkigyvrvit aalsffvmkn hptaftwlys tsclldaldg 61 tmarkynqvs slgavldmvt drsstaglmc flcvqypqwc vffqlmlgld itshymhmya 121 slsagktshk svgegesrll hlyytrrdvl fticafnelf yaglylqlfs nsatfgkwtt 181 iisfpgyvfk qtanvvqlkr aaliladnda knaneknkty // LOCUS NP_015439 315 aa linear PLN 30-JUN-2025 DEFINITION Ale2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015439 VERSION NP_015439.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184211.1 REFERENCE 1 (residues 1 to 315) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 315) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 315) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 315) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 315) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11529. Method: conceptual translation. FEATURES Location/Qualifiers source 1..315 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..315 /product="Ale2p" /calculated_mol_wt="36619" Region 98..302 /region_name="TLC" /note="TRAM, LAG1 and CLN8 homology domains; smart00724" /db_xref="CDD:214789" CDS 1..315 /gene="ALE2" /locus_tag="YPR114W" /coded_by="NM_001184211.1:1..948" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071618 lysophosphatidylethanolamine acyltransferase activity [PMID:39970228]" /experiment="EXISTENCE:mutant phenotype:GO:0036152 phosphatidylethanolamine acyl-chain remodeling [PMID:39970228]" /note="Lysophosphatidylethanolamine acyltransferase that regulates phospholipid composition; involved in remodeling membrane phospholipid acyl chains; TRAM-LAG1-CLN8 domain-containing (TLCD) protein family member; homolog of human TLCD1; distant similarity to yeast ceramide synthases, Lag1p and Lac1p; mutation confers sensitivity to inhibitors of sphingolipid biosynthesis" /db_xref="GeneID:856230" /db_xref="SGD:S000006318" ORIGIN 1 mdvllslpqp elfkttvipf lanrniikse ailsnlhsif yvaifyhiwf lfgkwilfph 61 lvkwkldydq khnvkkdekt tserqaqhyk kkytslinqs svhlisllqs ivvlyyslkf 121 lldpkasaep yqtshsrvft enrdtqvici faigyfvwdi yistmystfp fvvhgiistv 181 vfciglkpyi qyyapvflmf elsnpslnfr wfgikflpqk skfcslllll nnltlmvvff 241 aariawgwfq igklcydfyq vrnepgflvf dtivilagnf vldilnviwf stmvsvaakv 301 lkkgesvdkv tkneq // LOCUS NP_015440 1083 aa linear PLN 30-JUN-2025 DEFINITION Rgc1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015440 VERSION NP_015440.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184212.1 REFERENCE 1 (residues 1 to 1083) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1083) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1083) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1083) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1083) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1083) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1083) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11530. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1083 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1083 /product="Rgc1p" /calculated_mol_wt="120264" Region 270..461 /region_name="BAR_4" /note="BAR-like domain; pfam20400" /db_xref="CDD:466549" Region 485..>538 /region_name="PH_20" /note="PH domain; pfam20399" /db_xref="CDD:466548" CDS 1..1083 /gene="RGC1" /locus_tag="YPR115W" /coded_by="NM_001184212.1:1..3252" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:11914276]" /experiment="EXISTENCE:mutant phenotype:GO:0090372 positive regulation of glycerol transport [PMID:19956799]" /note="Putative regulator of the Fps1p glycerol channel; multiply phosphorylated by Hog1p under osmotic stress; contains a pleckstrin homology domain; forms homodimers and heterodimerizes with paralog Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm" /db_xref="GeneID:856231" /db_xref="SGD:S000006319" ORIGIN 1 msdyftfpkq enggiskqpa tpgstrsssr nlelpknyrs fggssdelas mysadsqylm 61 dmipdsltlk nepasgntqm ngpdgkenkd ikldeyilpk tdprspyyin mpipkklpks 121 egkarakqkv nradpsdldv eniyetsgef vreyptdili drfhkwkkil ksliayfrea 181 aysqeqiari nyqmknavkf afltdledet nklvdpsisk lptkkpqpvp laaqkldsky 241 dtdveqpqsi qsvpseevas assgfmkfgs gsiqdiqvil kkyhlslgsq qykiskeila 301 yiipkltdlr kdlttkmkei kelngdfktn igehikitsr llnkyiasvk lldeastsgd 361 kqgeklkpkh dpyllklqld lqlkrqllee nylreaflnl qsaalqleki vyskiqsalq 421 rysalidsea rlmiknlche lqqgilsrpp avewdnfvsh hptclmnlks tdpppqprrl 481 sdivypnmks plakcirvgy llkktessks ftkgyfvltt nylhefkssd ffldsksprs 541 knkpvveqsd isrvnkdgtn agshpsskgt qdpkltkrrk glsssnlypi sslslndcsl 601 kdstdstfvl qgyasyhspe dtctkesstt sdlacptktl asnkgkhqrt psalsmvsvp 661 kflksssvpk eqkkakeean inkksicekr vewtfkifsa sleptpeesk nfkkwvqdik 721 altsfnstqe rsnfieekil ksrnhnngks sqrsknstyi tpvdsfvnls ekvtpsssvt 781 tlntrkranr pryidipksa nmnagamnsv yrskvntpai dengnlaivg etknsapqng 841 msytirtpck spyspytgeg mlynrsadnl masssrkasa pgevpqiavs nhgdeaiipa 901 saysdsshks srassvasih nqrvdfypsp lmnlpgvsps claldgnang yfgiplncns 961 earrgsdlsp femesplfee nrtqncsgsr kssachiphq cgprkegnds rliygnekga 1021 sqsrltlkep ltskgveapy sslkktysae nvpltstvsn dkslhsrkeg stntvpatsa 1081 ssk // LOCUS NP_015441 277 aa linear PLN 30-JUN-2025 DEFINITION Rrg8p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015441 VERSION NP_015441.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184213.1 REFERENCE 1 (residues 1 to 277) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 277) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 277) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 277) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 277) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11531. Method: conceptual translation. FEATURES Location/Qualifiers source 1..277 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..277 /product="Rrg8p" /calculated_mol_wt="31002" Region 8..273 /region_name="RRG8" /note="Required for respiratory growth protein 8 mitochondrial; pfam17068" /db_xref="CDD:293673" CDS 1..277 /gene="RRG8" /locus_tag="YPR116W" /gene_synonym="MTA1" /coded_by="NM_001184213.1:1..834" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0099617 matrix side of mitochondrial inner membrane [PMID:30759361]" /experiment="EXISTENCE:mutant phenotype:GO:0000002 mitochondrial genome maintenance [PMID:19751518]" /experiment="EXISTENCE:mutant phenotype:GO:0097745 mitochondrial tRNA 5'-end processing [PMID:30759361]" /note="hypothetical protein; required for efficient 5' processing of mitochondrial tRNAs, for respiratory growth and mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport; localizes to the matrix side of the inner mitochondrial membrane" /db_xref="GeneID:856232" /db_xref="SGD:S000006320" ORIGIN 1 mglpksaykk llidcptrvi nkncaqrvkd vsplitnfek wsdkrkklyf kdeeemvgqf 61 hlenfnlknn lygrllaspm raekisklks crelliplkv vpstgkdqha dkdklklvpt 121 ldysksykss yvlnsasivq dnlaaatswf pisvlqtstp kslevdsstf iteynanlha 181 fikarlsvip nvgpssinrv llicdkrktp pieiqvvshg kglpitqsvf nlgylheptl 241 eaivskdavt ngiyldadnd kdlikhlyst llfhsvn // LOCUS NP_015442 2489 aa linear PLN 30-JUN-2025 DEFINITION Hob2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015442 VERSION NP_015442.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184214.1 REFERENCE 1 (residues 1 to 2489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 2489) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 2489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 2489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 2489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 2489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 2489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11532. Method: conceptual translation. FEATURES Location/Qualifiers source 1..2489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..2489 /product="Hob2p" /calculated_mol_wt="285774" Region 792..944 /region_name="DUF2405" /note="Domain of unknown function (DUF2405); pfam10293" /db_xref="CDD:431201" Region 974..1065 /region_name="Fmp27_SW" /note="RNA pol II promoter Fmp27 protein domain; pfam10305" /db_xref="CDD:431207" Region 1085..1234 /region_name="Fmp27_GFWDK" /note="RNA pol II promoter Fmp27 protein domain; pfam10347" /db_xref="CDD:402113" Region 1449..1945 /region_name="Fmp27_WPPW" /note="RNA pol II promoter Fmp27 protein domain; pfam10359" /db_xref="CDD:431231" Region 1958..2401 /region_name="Apt1" /note="Golgi-body localization protein domain; pfam10351" /db_xref="CDD:463055" CDS 1..2489 /gene="HOB2" /locus_tag="YPR117W" /coded_by="NM_001184214.1:1..7470" /note="Modulator of cellular lipid distribution; localizes to ER-PM and ER-mitochondria contact sites; shares homology with lipid transfer proteins Vps13p and Atg2p; homolog of D. melanogaster Hobbit protein" /db_xref="GeneID:856233" /db_xref="SGD:S000006321" ORIGIN 1 msmlpwsqir dvsklllgfm lfiisiqkia silmswilml rhstirkisf gyffgtsirr 61 afiltdfaqi yigkitlrig wkpgivfhnv dlklfgkdsh itahstkdsr tyfnprdqtf 121 tfvinrrvls ilklvfsfst ffhtlaltvp ngkqyklnig sitishphdd tikleaflhd 181 fthpetkdtl nhtgffmvck igkeddtgsn ctkvilknwk sslkisdvcw hlpekkgknl 241 hsepvepfsa gddaemltsy rkmlkpfhyp lktlnildlk venvkliykk kftirissaq 301 lylesisiln nvsalellpl nkptwgdfel slsanavvvd idgntavrip fgnviltsdi 361 llflldnvpl rrtkvssiln iinpsvflti hqvlevlhlv dkfdspetss ctntndrsln 421 ildldidrlp sfnfellmsn fisrlhisde envtfkvfst halfsrnnls mtpkkgqvmq 481 irpdwpfakt alvsdqlsny ikivgtslsy lripteqdan pvsipvcgfe rldtfldefs 541 nsklivqstl rhsyvsleni evlhtlsraf dkiyllissr tkrnaahkan ggklgdlnea 601 kktfnwslkl rmkdiscsll vagflpknld pveaenfnls dvtrgakvvf tesilladsq 661 eknftiidas vyrfmdgtty kpspeviiqf tnlllsfnds deihfslpki kfkmdvniiw 721 lwfyirsiwi kfrpnsklsr nsvssvksvn vldrlrvdig kmiieltlph ntevllifer 781 iglssstknl tiaslsayvv svyvkhikvy vsllnindfe ldteelickk savintslih 841 fhaeyhfrfy mitdnivtly ksfkqiklaf snlnefkrly pqqqfpkkvp nlhiccqdfl 901 idieedpfeq elglilkvgv leqrerlkkl eefkeklsty edmnvrlrsl ydtsrgqsff 961 pefyandqey eqkaylrlle nfstswiary rkaklsfygm pyrvisreel gtkyhlftrq 1021 ktstvanlvv kdldfklgsp sfpldnymdf vyqygkkvpk steytlliil glkiksalwe 1081 lrlrdypipa isfpdtfttg dvvfaekmpa pcalhtvyvp fvssaqrspy ndantiyglh 1141 iirtinsvkt yfnirsmvts sssaritwgk slqpgyeslm lwfdfltkpl idpskklgfw 1201 dkfrylvhgk wiyefseese ihlnikgshd pykitddgag lafcwsggtt iyvhnstdpk 1261 eflkiesqrf qlavpdfakv skfdkvfmkl dgrviwtlgl lfeqgdiska gdeerflpnr 1321 phyeiqlmnp dgvadldhhd tykgfrtsfi hmsfgvysse hgsinslyla pyalthffkw 1381 wnlfhtytsg pirqgrlftd vlqnktkfgr slftiayqlh lkrlmvthiy rhittqydle 1441 kdrkitftgl kgrfdslkid lhqkrvklth tnqklnkskp vwkfkmsrge idcaeadiri 1501 lstlfdqeav keiltsgldg iledepsrpi tpqdveylre sdwydyedyi dlnqvplgss 1561 lplkleaipl lysprisyfr kinddgyvla ypfgteeshn cligknhpel tqeklaterk 1621 reieeqlkll hitlselqsn kgggsvsgns eryarelkae vaelnhrlht vntilsdlki 1681 setipggntd gdsssslsdt dvnlenappi qnrisllrtn tvesfvsmrk astmqvesty 1741 dnrfmvhnie lkidnkirhh lleyassafe rksmrfavty ksvtilkell gnvltgvrts 1801 vedygsiled dlasnsefie hfeklirevp sddfdyvdny lfrlispqvq iksdvernaa 1861 vilaardiem giidivqvyg ksgkripvdv dtivetrysa vskdiqlftl fkkdlegpeg 1921 rffhkngygs dkesdiwppw iplemcfdgs lldkhvflkr rsmfltyvap nplffsandt 1981 safsydsrfr iafpglvlts dcqqycavya iaedllsfgs sldekvekls rilftdevrn 2041 nlenldvsvv talqerikel yytraylklh eprlfmksgq eltfdiqtst lkltllmtai 2101 kktydrmgsg nrviqkrlrw qvgtdeliwe lydesktpfv tiglgpstfi rsetsdgtns 2161 nkvsisslqc fnqqenpvyt ellapfyens synknapmve ifwilgpsvg gisdlqdliv 2221 slqplifkmd hktseklmny lfpkieqtsi epnspelvpr sstssffsss pvlrhslsng 2281 slsvydakdv dswdlrsiqs kegikkhkgd hrklsaslfv qpdyninemv krsgtffnvk 2341 siiirktlms vcykgshsll tdvnnlivrv pvlkyhnklw sreefftalk rdvvrivlqh 2401 lgniignkfl phkkenkkkt smeihrllsp dsqnrdnshi leveghnsfy ssthssdirs 2461 insdetynen dgngvkpfyp vtsefsknk // LOCUS NP_015443 411 aa linear PLN 30-JUN-2025 DEFINITION S-methyl-5-thioribose-1-phosphate isomerase MRI1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015443 VERSION NP_015443.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184215.1 REFERENCE 1 (residues 1 to 411) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 411) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 411) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 411) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 411) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11533. Method: conceptual translation. FEATURES Location/Qualifiers source 1..411 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..411 /product="S-methyl-5-thioribose-1-phosphate isomerase MRI1" /EC_number="5.3.1.23" /calculated_mol_wt="44889" Region 35..399 /region_name="eIF-2B_rel" /note="eIF-2B alpha/beta/delta-related uncharacterized proteins; TIGR00524" /db_xref="CDD:273119" CDS 1..411 /gene="MRI1" /locus_tag="YPR118W" /coded_by="NM_001184215.1:1..1236" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0046523 S-methyl-5-thioribose-1-phosphate isomerase activity [PMID:15215245]" /experiment="EXISTENCE:mutant phenotype:GO:0019509 L-methionine salvage from methylthioadenosine [PMID:15215245|PMID:18625006]" /note="5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway" /db_xref="GeneID:856234" /db_xref="SGD:S000006322" ORIGIN 1 msleaivfdr sepenvsvkv ldqlllpytt kyvpihtidd gysviksmqv rgapaiaivg 61 slsvltevql ikhnptsdva tlyslvnwes tktvlnkrld fllssrptav nlsnslveik 121 nilksssdlk afdgslynyv celidedlan nmkmgdngak ylidvlqkdg fkdefavlti 181 cntgslatsg ygtalgvirs lwkdslaktd kadsgldnek cprmghvfpl etrpynqgsr 241 ltayelvydk ipstlitdss iayrirtspi pikaafvgad rivrngdtan kigtlqlavi 301 ckqfgikffv vapkttidnv tetgddiive ernpeefkvv tgtvinpeng slilnesgep 361 itgkvgiapl einvwnpafd itphelidgi iteegvftkn ssgefqlesl f // LOCUS NP_015444 491 aa linear PLN 30-JUN-2025 DEFINITION B-type cyclin CLB2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015444 VERSION NP_015444.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184216.1 REFERENCE 1 (residues 1 to 491) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 491) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 491) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 491) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 491) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11534. Method: conceptual translation. FEATURES Location/Qualifiers source 1..491 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..491 /product="B-type cyclin CLB2" /calculated_mol_wt="56116" Region 8..487 /region_name="COG5024" /note="Cyclin [Cell division and chromosome partitioning]" /db_xref="CDD:227357" Site order(228..229,232..233,236..237,240,312..313,316..320, 323..325,342,345..346,349..350,353..354) /site_type="other" /note="putative CDK interface [polypeptide binding]" /db_xref="CDD:410271" CDS 1..491 /gene="CLB2" /locus_tag="YPR119W" /coded_by="NM_001184216.1:1..1476" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:12972503|PMID:11171327]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:12972503]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:12972503]" /experiment="EXISTENCE:direct assay:GO:0005819 spindle [PMID:12972503]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12972503]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:1731251]" /experiment="EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:1387566]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:8455600]" /experiment="EXISTENCE:mutant phenotype:GO:0005737 cytoplasm [PMID:11171327]" /experiment="EXISTENCE:mutant phenotype:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:1731251|PMID:1849457]" /experiment="EXISTENCE:mutant phenotype:GO:0032888 regulation of mitotic spindle elongation [PMID:23468650]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:22918234]" /note="B-type cyclin involved in cell cycle progression; also involved in response to DNA damage; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB2 has a paralog, CLB1, that arose from the whole genome duplication" /db_xref="GeneID:856236" /db_xref="SGD:S000006323" ORIGIN 1 msnpienten sqntsssrfl rnvqrlalnn vtnttfqksn annpaltnfk stlnsvkkeg 61 sripqftres vsrstaaqee krtlkengiq lpknnllddk enqdpssqqf galtsikegr 121 aelpanislq esssakeiiq hdplkgvgss tevvhnsven eklhparsql qvrntesetd 181 sgkkrpisti veqelpkkfk vcdengkeey ewedldaedv ndpfmvseyv ndifeylhql 241 evitlpkked lyqhrnihqn rdilvnwlvk ihnkfgllpe tlylainimd rflgkelvql 301 dklqlvgtsc lfiaskyeev yspsikhfas etdgactede ikegekfilk tlkfnlnypn 361 pmnflrrisk addydiqsrt lakflleisl vdfrfigilp slcaaaamfm srkmlgkgkw 421 dgnlihysgg ytkeelapvc hmimdylvsp ivhdefhrky qsrrfmkasi isvqwalkvr 481 kngydimtlh e // LOCUS NP_015445 435 aa linear PLN 30-JUN-2025 DEFINITION B-type cyclin CLB5 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015445 VERSION NP_015445.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184217.1 REFERENCE 1 (residues 1 to 435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 435) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11535. Method: conceptual translation. FEATURES Location/Qualifiers source 1..435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..435 /product="B-type cyclin CLB5" /calculated_mol_wt="50300" Region 1..431 /region_name="COG5024" /note="Cyclin [Cell division and chromosome partitioning]" /db_xref="CDD:227357" CDS 1..435 /gene="CLB5" /locus_tag="YPR120C" /coded_by="NM_001184217.1:1..1308" /experiment="EXISTENCE:direct assay:GO:0001932 regulation of protein phosphorylation [PMID:7954792]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:10848575]" /experiment="EXISTENCE:direct assay:GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity [PMID:7954792]" /experiment="EXISTENCE:genetic interaction:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8253070]" /experiment="EXISTENCE:genetic interaction:GO:0006279 premeiotic DNA replication [PMID:9732268]" /experiment="EXISTENCE:genetic interaction:GO:0010696 positive regulation of mitotic spindle pole body separation [PMID:11438663|PMID:16688214]" /experiment="EXISTENCE:genetic interaction:GO:0045740 positive regulation of DNA replication [PMID:8319908]" /experiment="EXISTENCE:genetic interaction:GO:1901673 regulation of mitotic spindle assembly [PMID:8319908]" /experiment="EXISTENCE:mutant phenotype:GO:0000082 G1/S transition of mitotic cell cycle [PMID:8319908|PMID:8253070]" /experiment="EXISTENCE:mutant phenotype:GO:0000086 G2/M transition of mitotic cell cycle [PMID:8319908]" /experiment="EXISTENCE:mutant phenotype:GO:0006279 premeiotic DNA replication [PMID:9732268]" /experiment="EXISTENCE:mutant phenotype:GO:0045740 positive regulation of DNA replication [PMID:9734354|PMID:8319908]" /note="B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase; CLB5 has a paralog, CLB6, that arose from the whole genome duplication" /db_xref="GeneID:856237" /db_xref="SGD:S000006324" ORIGIN 1 mgenhdheqs ikrnsmiyne nerqlcnsnl kilqnkrals kndssskqqv qdskprralt 61 dvpvnnnpls qnkrivagsk aakvrreeni rpivsavqkr qiyndrtaae qeeeeeeege 121 dddaasivnk krridaegvs eivgwqdldy vekddtamva eysaeifafl yrreletlps 181 hnylldktsk yylrpsmrti lvdwlvevhe kfqcypetlf lsinlmdrfl aknkvtmnkl 241 qllavtslfi aakfeevnlp klaeyayitd gaaskndikn aemfmltsle fnigwpnpln 301 flrriskadd ydpvnrnigk fileyaycch qfihlppstv samamyiarr mtnrnknelw 361 ngtlqhysgg idpihdeafq slcidlvkdi asskthldsl ilkykkpryg svyfqtfkwc 421 tsemhsnfqn lfnlk // LOCUS NP_015446 572 aa linear PLN 30-JUN-2025 DEFINITION putative phosphomethylpyrimidine kinase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015446 VERSION NP_015446.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184218.2 REFERENCE 1 (residues 1 to 572) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 572) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 572) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 572) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11536. On Apr 26, 2011 this sequence version replaced NP_015446.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..572 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..572 /product="putative phosphomethylpyrimidine kinase" /calculated_mol_wt="63167" Site order(47,54,56..57,59,63,66..67,70,73..78,80,83..87,92..93, 95,97..98,101,104,108..109) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:238574" Site order(53,65,86,122,265) /site_type="other" /note="substrate binding site [chemical binding]" /db_xref="CDD:238574" Region 55..313 /region_name="Phos_pyr_kin" /note="Phosphomethylpyrimidine kinase; pfam08543" /db_xref="CDD:430062" Site order(148,185,221,262,264) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:238574" Region 361..571 /region_name="TENA_THI-4" /note="TENA/THI-4/PQQC family; pfam03070" /db_xref="CDD:397272" CDS 1..572 /gene="THI22" /locus_tag="YPR121W" /coded_by="NM_001184218.2:1..1719" /experiment="EXISTENCE:expression pattern:GO:0009228 thiamine biosynthetic process [PMID:10383756]" /note="Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum and vacuole respectively" /db_xref="GeneID:856239" /db_xref="SGD:S000006325" ORIGIN 1 mviillglct lgfprtafcp simtnstvsi ntpppyltla cneklptvms iagsdssgga 61 gveadiktit ahrcyamtcv ttltaqtpvk vygaqnipkk mvsqildanl qdmkcnvikt 121 gmltvdaiev lhekllqlge nrpklvidpv lcaasdsspt gkdvvsliie kispfadilt 181 pnisdcfmll genrevsklq dvleiakdls ritncsnilv kgghipcddg kekhitdvly 241 lgaeqkfitf kgqfvnttrt hgagctlasa iasnlargys lsqsvyggie yvqnaiaigc 301 dvtkkavkvg pinhvyavei plekmltdec ftasdavpkk piegsldkip ggsffnylin 361 hpkvkphwda yvnhefvkrv adgtlerkkf qffieqdyly lidyvrvccv tgsksptled 421 lekdlviadc arnelneher rlreefgvkd pdylqkikrg palraycryl idisrrgnwq 481 eivvalnpcl mgyvyavdkv kdkitaaegs iysewcdtca ssfcyqavle gerlmnhile 541 typpdqldsl vtifargcel etnfwtaame ye // LOCUS NP_015447 1208 aa linear PLN 30-JUN-2025 DEFINITION Axl1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015447 VERSION NP_015447.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184219.1 REFERENCE 1 (residues 1 to 1208) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1208) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1208) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1208) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1208) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11537. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1208 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1208 /product="Axl1p" /calculated_mol_wt="138201" Region 21..973 /region_name="Ptr" /note="Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; COG1025" /db_xref="CDD:440648" CDS 1..1208 /gene="AXL1" /locus_tag="YPR122W" /gene_synonym="FUS5; STE22" /coded_by="NM_001184219.1:1..3627" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12176366]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12176366]" /experiment="EXISTENCE:genetic interaction:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:7569998]" /experiment="EXISTENCE:mutant phenotype:GO:0000755 cytogamy [PMID:9744878]" /experiment="EXISTENCE:mutant phenotype:GO:0004222 metalloendopeptidase activity [PMID:7569998]" /experiment="EXISTENCE:mutant phenotype:GO:0007120 axial cellular bud site selection [PMID:7990931]" /experiment="EXISTENCE:mutant phenotype:GO:0071432 peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion [PMID:7569998]" /note="Haploid specific endoprotease of a-factor mating pheromone; performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells" /db_xref="GeneID:856240" /db_xref="SGD:S000006326" ORIGIN 1 mslrevtnye vsfyiplsys nrthkvcklp ngilaliisd ptdtssscsl tvctgshndp 61 kdiaglahlc ehmilsagsk kypdpglfht liaknngsqn afttgeqttf yfelpntqnn 121 geftfesild vfasffkepl fnplliskei yaiqsehegn issttkifyh aarilanpdh 181 pfsrfstgni hslssipqlk kiklksslnt yfennffgen itlcirgpqs vniltklals 241 kfgdikpksa vkersisirt rsfrrskslk krqdsskndy sdlktfkiln ttwekkyknt 301 mcfqqfpecn sifinsnkvp imrllfpvsd kntrftkddi kiyshlwcel fgdespgsls 361 yylaskgwlt gcfaftsefa igdiglilel eltnsgweni krittivlnr llpsfyvmni 421 dylitflkeq nlidlvsfly qssedlpmee csklsgilqd dlecltppni fkgfksliei 481 ddpniekyen tkaniqwwtg qaikfqnflk sfmnhdnmrl lllgniksgn ifdkmknksd 541 ictdffyefe yytanvhlas dnkfhsnssy efnfptgnlf lpdcvsdplk lqqlflecsl 601 kskfatlrpq iyseptrtkp qlvsenqnye mwilkedpnf asdnksvvsf evlglgikps 661 peatihlevl aqalfiitss flypalrigy tyeiassskg nvtlrftisg fpegvftivk 721 tfvdtlklia tdptflskdt lrkarilvrn kyknassdnc vklasvglli vlekyiwtle 781 drinalelte lesfekfcfl fwrnpkhlvl fmqgsleyad ainrylnnnf tqhlkisneg 841 skptirlypp pstkdldqgt nafisynghq ddpnnsivyf iqtaqrddik nltltfltey 901 lfsltlvpdl rnkkqigyiv lgglrvltdt vgihitvmsg ssghnletri neylsylqlq 961 vlnrftefdf rrillepfln llkqnstkqf egsagpvdll neivanvqng dnytlnnkqm 1021 rqhrkvrnki aegrlnfqed hemidisflq kltlkkylaf feskisiysa qrsklsimit 1081 spmaekeias rkmflqleaf lkingfaikn edlkkivehs kgnpillvkn lftyfrrrne 1141 vfklgtvvlq eilkiigmnl kqrygsilgf ssqdgegqei ekfwnndtsp ivplqelpep 1201 nffrkaaf // LOCUS NP_015449 406 aa linear PLN 30-JUN-2025 DEFINITION high-affinity Cu transporter CTR1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015449 VERSION NP_015449.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184221.1 REFERENCE 1 (residues 1 to 406) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 406) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 406) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 406) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 406) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11538. Method: conceptual translation. FEATURES Location/Qualifiers source 1..406 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..406 /product="high-affinity Cu transporter CTR1" /calculated_mol_wt="44311" Region 130..281 /region_name="Ctr" /note="Ctr copper transporter family; pfam04145" /db_xref="CDD:461194" CDS 1..406 /gene="CTR1" /locus_tag="YPR124W" /coded_by="NM_001184221.1:1..1221" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:22842922|PMID:7929270]" /experiment="EXISTENCE:mutant phenotype:GO:0005375 copper ion transmembrane transporter activity [PMID:7929270]" /experiment="EXISTENCE:mutant phenotype:GO:0015677 copper ion import [PMID:7929270]" /note="High-affinity copper transporter of plasma membrane; mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels; protein increases in abundance and relocalizes from nucleus to plasma membrane upon DNA replication stress; human homolog SLC31A1 can complement a yeast ctr1 ctr3 double deletion" /db_xref="GeneID:856241" /db_xref="SGD:S000006328" ORIGIN 1 megmnmgssm nmdamssask tvassmasms mdamssaskt ilssmssmsm eamssasktl 61 astmssmasm smgsssmsgm smsmsstpts sasaqttsds smsgmsgmss sdnssssgmd 121 mdmsmgmnyy ltptyknypv lfhhlhanns gkafgifllf vvaafvykll lfvswclevh 181 wfkkwdkqnk ystlpsansk degkhydten nfeiqglpkl pnllsdifvp slmdlfhdii 241 raflvftstm iiymlmlatm sfvltyvfav itglalsevf fnrckiamlk rwdiqreiqk 301 akscpgfgnc qcgrhpepsp dpiavadtts gsdqstrlek nneskvaise nnqkktptqe 361 egcncatdsg knqanierdi lensklqeqs gnmdqnllpa ekfthn // LOCUS NP_015450 454 aa linear PLN 30-JUN-2025 DEFINITION Ylh47p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015450 VERSION NP_015450.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184222.1 REFERENCE 1 (residues 1 to 454) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 454) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 454) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 454) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 454) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11539. Method: conceptual translation. FEATURES Location/Qualifiers source 1..454 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..454 /product="Ylh47p" /calculated_mol_wt="52044" Region 119..348 /region_name="LETM1_RBD" /note="LETM1-like, RBD; pfam07766" /db_xref="CDD:462258" CDS 1..454 /gene="YLH47" /locus_tag="YPR125W" /gene_synonym="MRS7" /coded_by="NM_001184222.1:1..1365" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14562095|PMID:16823961|PMID:24390141]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16476776]" /experiment="EXISTENCE:genetic interaction:GO:0006813 potassium ion transport [PMID:20197279]" /experiment="EXISTENCE:genetic interaction:GO:1902600 proton transmembrane transport [PMID:20197279]" /experiment="EXISTENCE:mutant phenotype:GO:0032979 protein insertion into mitochondrial inner membrane from matrix [PMID:16476776]" /note="Mitochondrial inner membrane protein; exposed to the mitochondrial matrix; associates with mitochondrial ribosomes; NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome" /db_xref="GeneID:856243" /db_xref="SGD:S000006329" ORIGIN 1 mlkyrslpik raihhpapgi tpisprimvs rlrvipsfnl kfnrwnssvp esskkelktt 61 dgnqesaskv spvkekekvp fkvkmqkalr hywdgskllg leikisskll mksaagyplt 121 rrenlqlkrt tqdivrlvpf aafliipfae lllpfalklf pnllpstyes skkrenklen 181 lrntrklmse iiknnkshfk pnniseeqka lfnrfythvr atgvpesrqq lievarlftd 241 dtvldnvtrp ylialakymn lqpfgtdvml ryrirykmle lkkddlsiyy edaeqlslse 301 lktacasrgi rsvdvepsvl ysnlrlwlnm rlkdkipstl limataynyg nvqskeslyd 361 alcdvligip delyhevkvn vvkedeasak qklkqlreqe eimkeeeqqe enaivsvkde 421 lslddqdkni daaapdvkph dtkpigeaaa ikek // LOCUS NP_015452 345 aa linear PLN 30-JUN-2025 DEFINITION pyridoxine 4-dehydrogenase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015452 VERSION NP_015452.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184224.1 REFERENCE 1 (residues 1 to 345) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 345) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 345) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 345) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 345) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11540. Method: conceptual translation. FEATURES Location/Qualifiers source 1..345 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..345 /product="pyridoxine 4-dehydrogenase" /EC_number="1.1.1.65" /calculated_mol_wt="38470" Region 8..329 /region_name="AKR_AKR8A1-2" /note="AKR8A family of aldo-keto reductase (AKR); cd19077" /db_xref="CDD:381303" Site order(18..20,55,60,89,127..128,163..164,185,214..220,276, 300..305,308,311..312) /site_type="active" /note="putative active site [active]" /db_xref="CDD:381303" Site order(55,60,89,127) /site_type="active" /note="catalytic tetrad [active]" /db_xref="CDD:381303" CDS 1..345 /locus_tag="YPR127W" /coded_by="NM_001184224.1:1..1038" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="Putative pyridoxine 4-dehydrogenase; differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus" /db_xref="GeneID:856245" /db_xref="SGD:S000006331" ORIGIN 1 msvadlknni hkldtgyglm sltwraepip qsqafeamhr vvelsrergh kaffnvgefy 61 gpdfinlsyv hdffakypdl rkdvvisckg gadnatltpr gshddvvqsv knsvsaiggy 121 idifevarid tslctkgevy pyesfealae misegviggi slsevneeqi raihkdwgkf 181 ltcvevelsl fsndilhngi aktcaelgls iicysplgrg lltgqlksna dipegdfrks 241 lkrfsdeslk knltlvrflq eeivdkrpqn nsitlaqlal gwvkhwnkvp eysgakfipi 301 psgssiskvn enfdeqktkl tdqefnaink ylttfhtvgd ryema // LOCUS NP_015453 328 aa linear PLN 30-JUN-2025 DEFINITION Ant1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015453 VERSION NP_015453.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184225.1 REFERENCE 1 (residues 1 to 328) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 328) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 328) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 328) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 328) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11541. Method: conceptual translation. FEATURES Location/Qualifiers source 1..328 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..328 /product="Ant1p" /calculated_mol_wt="36236" Region 3..106 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 121..212 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" Region 218..305 /region_name="Mito_carr" /note="Mitochondrial carrier protein; pfam00153" /db_xref="CDD:395101" CDS 1..328 /gene="ANT1" /locus_tag="YPR128C" /coded_by="NM_001184225.1:1..987" /experiment="EXISTENCE:direct assay:GO:0000295 adenine nucleotide transmembrane transporter activity [PMID:11566870]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005778 peroxisomal membrane [PMID:11566870]" /experiment="EXISTENCE:direct assay:GO:0015867 ATP transport [PMID:11566870]" /experiment="EXISTENCE:mutant phenotype:GO:0000295 adenine nucleotide transmembrane transporter activity [PMID:11390660]" /experiment="EXISTENCE:mutant phenotype:GO:0006635 fatty acid beta-oxidation [PMID:11566870|PMID:11390660]" /experiment="EXISTENCE:mutant phenotype:GO:0007031 peroxisome organization [PMID:11390660]" /note="Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation" /db_xref="GeneID:856246" /db_xref="SGD:S000006332" ORIGIN 1 mltlesaltg avasamania vypldlskti iqsqvspsss edsnegkvlp nrryknvvdc 61 minifkekgi lglyqgmtvt tvatfvqnfv yffwytfirk symkhkllgl qslknrdgpi 121 tpstieelvl gvaaasisql ftspmavvat rqqtvhsaes akftnvikdi yrenngdita 181 fwkglrtgla ltinpsitya sfqrlkevff hdhsndagsl savqnfilgv lskmistlvt 241 qplivakaml qsagskfttf qeallylykn eglkslwkgv lpqltkgviv qgllfafrge 301 ltkslkrlif lyssfflkhn gqrklast // LOCUS NP_015454 349 aa linear PLN 30-JUN-2025 DEFINITION Scd6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015454 VERSION NP_015454.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184226.1 REFERENCE 1 (residues 1 to 349) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 349) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 349) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 349) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 349) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11542. Method: conceptual translation. FEATURES Location/Qualifiers source 1..349 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..349 /product="Scd6p" /calculated_mol_wt="39059" Region 1..76 /region_name="LSm14_N" /note="Like-Sm protein 14, N-terminal domain; cd01736" /db_xref="CDD:212483" Site order(9..15,17..29,32..36) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212483" Site order(27,29,67) /site_type="other" /note="putative RNA binding site [nucleotide binding]" /db_xref="CDD:212483" Site 63..74 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212483" Region 200..280 /region_name="FDF" /note="FDF domain; pfam09532" /db_xref="CDD:430668" CDS 1..349 /gene="SCD6" /locus_tag="YPR129W" /gene_synonym="LSM13" /coded_by="NM_001184226.1:1..1050" /experiment="EXISTENCE:direct assay:GO:0000932 P-body [PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405|PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0031370 eukaryotic initiation factor 4G binding [PMID:22284680]" /experiment="EXISTENCE:direct assay:GO:0045947 negative regulation of translational initiation [PMID:20832728]" /experiment="EXISTENCE:mutant phenotype:GO:0033962 P-body assembly [PMID:22284680]" /experiment="EXISTENCE:mutant phenotype:GO:0034063 stress granule assembly [PMID:22284680]" /experiment="EXISTENCE:mutant phenotype:GO:0045947 negative regulation of translational initiation [PMID:20832728]" /note="Repressor of translation initiation; binds eIF4G through its RGG domain and inhibits recruitment of the preinitiation complex; also contains an Lsm domain; may have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1; forms cytoplasmic foci upon DNA replication stress" /db_xref="GeneID:856247" /db_xref="SGD:S000006333" ORIGIN 1 msqyigktis lisvtdnryv glledidsek gtvtlkevrc fgtegrknwg peeiypnptv 61 ynsvkfngse vkdlsildan indiqpvvpq mmppasqfpp qqaqsppqaq aqahvqtnpq 121 vpkpesnvpa avagygvytp tstetatasm ndkstpqdtn vnsqsrergk ngenepkyqr 181 nknrssnrpp qsnrnfkvdi pnedfdfqsn nakftkgdst dvekekeles avhkqdesde 241 qfynkkssff dtiststetn tnmrwqeekm lnvdtfgqas arprfhsrgl grgrgnyrgn 301 rgnrgrggqr gnyqnrnnyq ndsgayqnqn dsysrpanqf sqppsnvef // LOCUS NP_015456 195 aa linear PLN 30-JUN-2025 DEFINITION peptide alpha-N-acetyltransferase complex B subunit NAT3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015456 VERSION NP_015456.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184228.1 REFERENCE 1 (residues 1 to 195) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 195) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 195) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 195) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 195) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11543. On May 29, 2003 this sequence version replaced NP_015456.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..195 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..195 /product="peptide alpha-N-acetyltransferase complex B subunit NAT3" /EC_number="2.3.1.254" /calculated_mol_wt="22790" Region 20..134 /region_name="Acetyltransf_1" /note="Acetyltransferase (GNAT) family; pfam00583" /db_xref="CDD:395465" CDS 1..195 /gene="NAT3" /locus_tag="YPR131C" /gene_synonym="NAA20; RAD56" /coded_by="NM_001184228.1:1..588" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0031416 NatB complex [PMID:12783868]" /experiment="EXISTENCE:genetic interaction:GO:0000001 mitochondrion inheritance [PMID:12808144]" /experiment="EXISTENCE:genetic interaction:GO:0032956 regulation of actin cytoskeleton organization [PMID:12808144]" /experiment="EXISTENCE:mutant phenotype:GO:0000001 mitochondrion inheritance [PMID:12808144]" /experiment="EXISTENCE:mutant phenotype:GO:0004596 protein-N-terminal amino-acid acetyltransferase activity [PMID:10545125]" /experiment="EXISTENCE:mutant phenotype:GO:0017196 N-terminal peptidyl-methionine acetylation [PMID:10545125]" /experiment="EXISTENCE:mutant phenotype:GO:0032956 regulation of actin cytoskeleton organization [PMID:12808144]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:23363603]" /note="Catalytic subunit of the NatB N-terminal acetyltransferase; NatB catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met" /db_xref="GeneID:856249" /db_xref="SGD:S000006335" ORIGIN 1 mttiqpfepv dlfktnnvnl diltenfple fyfeymiiwp dlffkssemt vdptfkhnis 61 gymmaktegk ttewhthita vtvaprfrri slasklcntl etmtdvmphe vnfidlfvkc 121 nnqlaiklye klgysvyrrv vgyynsaedg ypdtlkkvdd nkdafdmrka mardrnrsvr 181 pdgrshkcyp hdvrf // LOCUS NP_015457 145 aa linear PLN 30-JUN-2025 DEFINITION 40S ribosomal protein uS12 RPS23B [Saccharomyces cerevisiae S288C]. ACCESSION NP_015457 VERSION NP_015457.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184229.1 REFERENCE 1 (residues 1 to 145) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 145) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 145) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 145) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 145) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11544. Method: conceptual translation. FEATURES Location/Qualifiers source 1..145 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..145 /product="40S ribosomal protein uS12 RPS23B" /calculated_mol_wt="15907" Region 4..145 /region_name="PTZ00067" /note="40S ribosomal S23; Provisional" /db_xref="CDD:185422" Site order(28,30..34,36,38..43,45..51,62..70,76..78,86,88..91, 104..110,113..116,122..123,128,130,140..142) /site_type="other" /note="18S rRNA interaction site [nucleotide binding]" /db_xref="CDD:239465" Site order(62..63,114) /site_type="other" /note="streptomycin interaction site [chemical binding]" /db_xref="CDD:239465" Site 63..64 /site_type="other" /note="28S rRNA interaction site [nucleotide binding]" /db_xref="CDD:239465" Site order(64..69,90..98) /site_type="other" /note="aminoacyl-tRNA interaction site (A-site) [nucleotide binding]" /db_xref="CDD:239465" Site 99 /site_type="other" /note="eEF2 interaction site [polypeptide binding]" /db_xref="CDD:239465" CDS 1..145 /gene="RPS23B" /locus_tag="YPR132W" /coded_by="NM_001184229.1:1..438" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:6814480]" /experiment="EXISTENCE:direct assay:GO:0022627 cytosolic small ribosomal subunit [PMID:6814480]" /experiment="EXISTENCE:genetic interaction:GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:16246728]" /experiment="EXISTENCE:genetic interaction:GO:0006450 regulation of translational fidelity [PMID:8415737|PMID:8950190]" /experiment="EXISTENCE:mutant phenotype:GO:0006450 regulation of translational fidelity [PMID:8415737|PMID:8950190]" /note="Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit; required for translational accuracy; homologous to mammalian ribosomal protein S23 and bacterial S12; RPS23B has a paralog, RPS23A, that arose from the whole genome duplication; deletion of both RPS23A and RPS23B is lethal" /db_xref="GeneID:856250" /db_xref="SGD:S000006336" ORIGIN 1 mgkgkprgln sarklrvhrr nnrwaennyk krllgtafks spfggsshak givleklgie 61 skqpnsairk cvrvqlikng kkvtafvpnd gclnfvdend evllagfgrk gkakgdipgv 121 rfkvvkvsgv sllalwkekk ekprs // LOCUS NP_015458 410 aa linear PLN 30-JUN-2025 DEFINITION transcription factor SPN1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015458 VERSION NP_015458.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184230.1 REFERENCE 1 (residues 1 to 410) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 410) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 410) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 410) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 410) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11545. Method: conceptual translation. FEATURES Location/Qualifiers source 1..410 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..410 /product="transcription factor SPN1" /calculated_mol_wt="45951" Region 1..405 /region_name="COG5139" /note="Uncharacterized conserved protein [Function unknown]" /db_xref="CDD:227468" CDS 1..410 /gene="SPN1" /locus_tag="YPR133C" /gene_synonym="IWS1" /coded_by="NM_001184230.1:1..1233" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:12556496|PMID:18086892|PMID:12524336]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:29300974]" /experiment="EXISTENCE:genetic interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:12556496|PMID:12524336]" /experiment="EXISTENCE:genetic interaction:GO:0034243 regulation of transcription elongation by RNA polymerase II [PMID:18086892]" /experiment="EXISTENCE:mutant phenotype:GO:0005665 RNA polymerase II, core complex [PMID:32941642]" /experiment="EXISTENCE:mutant phenotype:GO:0006334 nucleosome assembly [PMID:29300974]" /experiment="EXISTENCE:mutant phenotype:GO:0016973 poly(A)+ mRNA export from nucleus [PMID:19034519]" /experiment="EXISTENCE:physical interaction:GO:0000993 RNA polymerase II complex binding [PMID:18086892|PMID:12556496]" /experiment="EXISTENCE:physical interaction:GO:0006357 regulation of transcription by RNA polymerase II [PMID:12556496]" /experiment="EXISTENCE:physical interaction:GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding [PMID:12556496]" /note="Protein involved in RNA polymerase II transcription; also required for histone modifications and splicing; constitutively recruited to the CYC1 promoter and required for recruitment of chromatin remodeling factors for the expression of CYC1 gene; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain is highly conserved throughout eukaryotes; mutations confer an Spt- phenotype" /db_xref="GeneID:856251" /db_xref="SGD:S000006337" ORIGIN 1 mstadqeqpk vveatpedgt assqkstina enentkqnqs mepqetskgt sndtkdpdng 61 ekneeaaide nsnveaaerk rkhistdfsd ddlekeehnd qslqptvenr askdrdssat 121 pssrqeleek ldrilkkpkv rrtrrdeddl eqyldekilr lkdemniaaq ldidtlnkri 181 etgdtsliam qkvkllpkvv svlskanlad tildnnllqs vriwleplpd gslpsfeiqk 241 slfaalndlp vktehlkesg lgrvvifytk skrveaqlar laekliaewt rpiigasdny 301 rdkrimqlef dseklrkksv mdsaknrkkk sksgedptsr gssvqtlyeq aaarrnraaa 361 paqtttdyky apvsnlsavp tnaravgvgs tlnnsemykr ltsrlnkkhk // LOCUS NP_015459 50 aa linear PLN 30-JUN-2025 DEFINITION Tom5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015459 VERSION NP_015459.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184307.1 REFERENCE 1 (residues 1 to 50) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 50) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 50) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 50) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 50) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11546. Method: conceptual translation. FEATURES Location/Qualifiers source 1..50 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..50 /product="Tom5p" /calculated_mol_wt="5854" Region 1..47 /region_name="Tom5" /note="Mitochondrial import receptor subunit or translocase; pfam10642" /db_xref="CDD:431410" CDS 1..50 /gene="TOM5" /locus_tag="YPR133W-A" /gene_synonym="MOM8A" /coded_by="NM_001184307.1:1..153" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:9217162|PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005742 mitochondrial outer membrane translocase complex [PMID:9217162]" /experiment="EXISTENCE:direct assay:GO:0070096 mitochondrial outer membrane translocase complex assembly [PMID:20668160]" /experiment="EXISTENCE:mutant phenotype:GO:0006626 protein targeting to mitochondrion [PMID:9217162]" /experiment="EXISTENCE:mutant phenotype:GO:0008320 protein transmembrane transporter activity [PMID:9217162]" /note="Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore" /db_xref="GeneID:856252" /db_xref="SGD:S000006433" ORIGIN 1 mfglpqqevs eeekrahqeq tektlkqaay vaaflwvspm iwhlvkkqwk // LOCUS NP_015460 268 aa linear PLN 30-JUN-2025 DEFINITION Mss18p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015460 VERSION NP_015460.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184231.1 REFERENCE 1 (residues 1 to 268) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 268) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 268) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 268) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 268) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11547. Method: conceptual translation. FEATURES Location/Qualifiers source 1..268 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..268 /product="Mss18p" /calculated_mol_wt="30826" CDS 1..268 /gene="MSS18" /locus_tag="YPR134W" /coded_by="NM_001184231.1:1..807" /experiment="EXISTENCE:direct assay:GO:0000372 Group I intron splicing [PMID:2842150]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:14576278]" /experiment="EXISTENCE:mutant phenotype:GO:0000372 Group I intron splicing [PMID:2842150]" /experiment="EXISTENCE:mutant phenotype:GO:0090615 mitochondrial mRNA processing [PMID:21257754]" /note="Nuclear encoded protein needed for splicing of mitochondrial intron; required for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions" /db_xref="GeneID:856253" /db_xref="SGD:S000006338" ORIGIN 1 mglpevnflr kncilvelkl fyqtvyppke lywnnritae lstfsnikya rptfavnngt 61 fqrtrpkldl vlassdirkl atvlfnlkal imntkgeept lttmtsvqtn eekndnleqk 121 ysslldrwng kvevhdspfl qlqrdsnllf aerpvryvst tegegvdiss eeffrleeeq 181 crrnydvlvd ehstpsvgmk dgqygpniih fepslyhtys slpmsmkfwl ngleddettm 241 mnideksaen ldillhgfkg fsnkrvkg // LOCUS NP_015461 927 aa linear PLN 30-JUN-2025 DEFINITION chromatin-binding protein CTF4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015461 VERSION NP_015461.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184232.1 REFERENCE 1 (residues 1 to 927) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 927) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 927) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 927) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 927) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 927) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 927) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11548. Method: conceptual translation. FEATURES Location/Qualifiers source 1..927 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..927 /product="chromatin-binding protein CTF4" /calculated_mol_wt="104294" Region 140..176 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 180..231 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region <233..347 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Region 233..272 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 279..311 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 478..779 /region_name="Mcl1_mid" /note="Minichromosome loss protein, Mcl1, middle region; pfam12341" /db_xref="CDD:463539" CDS 1..927 /gene="CTF4" /locus_tag="YPR135W" /gene_synonym="CHL15; POB1" /coded_by="NM_001184232.1:1..2784" /experiment="EXISTENCE:direct assay:GO:0000228 nuclear chromosome [PMID:11287619]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:20381454]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:0043596 nuclear replication fork [PMID:16962805]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714|PMID:17483413]" /experiment="EXISTENCE:mutant phenotype:GO:0000727 double-strand break repair via break-induced replication [PMID:20516198]" /experiment="EXISTENCE:mutant phenotype:GO:0006261 DNA-templated DNA replication [PMID:1448101]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:20980819]" /experiment="EXISTENCE:mutant phenotype:GO:0006281 DNA repair [PMID:1341195|PMID:1448101]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:11287619]" /experiment="EXISTENCE:mutant phenotype:GO:0034085 establishment of sister chromatid cohesion [PMID:23334284]" /note="Chromatin-associated protein; required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p); recruits Mms22p to replication forks during S phase, and may link DNA synthesis to sister chromatid cohesion" /db_xref="GeneID:856254" /db_xref="SGD:S000006339" ORIGIN 1 mvsvidklvf dfggktlvsl apdnntlcva nkngltkilk tnnpeeepet ldssklvssi 61 kcysnshflm ttmqgdalry nidssqeell arfalplrdc cvihsgkmav fggddlelil 121 lelddethkk haikideqvs qisynsqmni lavsmingkv qifsltstip nkvhelndyi 181 vansyddthr dkilsnmmdd idkdndndls etadpdennv adpefcaanr ictrvawhpk 241 glhfalpcad dtvkifsikg yslqktlstn lsstkahfid lqfdplrgty iaavdlnnkl 301 tvwnwetsei hytrefkrki tniawkiqad sktldlvlgt wsgsiaivqn laesvvsnip 361 dqsvaesstk hglfvdsesd lenlegnddi nksdklfsdi tqeanaedvf tqthdgpsgl 421 sekrkynfed eedfiddddg agyisgkkph nehsysrvhk thsfpislan tgkfrympfs 481 pagtpfgftd rryltmnevg yvstvknseq ysitvsffdv grfreyhfed lfgydlcfln 541 ekgtlfgqsk tgqiqyrphd sihsnwtkii plqagerits vaatpvrviv gtslgyfrsf 601 nqfgvpfave ktspivalta qnyrvfsvhy sqfhglsysl selgtsskry ykrecplpms 661 lpninsdmkk danldyynfn pmgikslffs sygdpcifgs dntllllskw rspeeskwlp 721 ildsnmeiwk msggkettdi hvwplalayd tlncilvkgk hiwpefplpl psemeirmpv 781 fvksklleen kailnkknei gadteaeege edkeiqipvs maaeeeylrs kvlselltdt 841 lendgemygn enevlaalng aydkallrlf asacsdqnve kalslahelk qdraltaavk 901 iseraelpsl vkkinnirea ryeqqlk // LOCUS NP_015463 573 aa linear PLN 30-JUN-2025 DEFINITION ribosomal RNA-processing protein RRP9 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015463 VERSION NP_015463.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184234.1 REFERENCE 1 (residues 1 to 573) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 573) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 573) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 573) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 573) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11549. Method: conceptual translation. FEATURES Location/Qualifiers source 1..573 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..573 /product="ribosomal RNA-processing protein RRP9" /calculated_mol_wt="64923" Region 233..500 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cl29593" /db_xref="CDD:475233" Site order(235,253,257,263..264,278..279,297,301,307..308, 320..321,338,343,349..350,377,382,387..388,400..401,415, 419,425..426,456,462..463,489,493,499..500) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 239..278 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 284..320 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 325..360 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 406..437 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 475..515 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..573 /gene="RRP9" /locus_tag="YPR137W" /coded_by="NM_001184234.1:1..1722" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0031428 box C/D methylation guide snoRNP complex [PMID:11081632]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:12068309]" /experiment="EXISTENCE:direct assay:GO:0034511 U3 snoRNA binding [PMID:23509373]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11105764]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11105764]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:11105764]" /note="Protein involved in pre-rRNA processing; associated with U3 snRNP; component of small ribosomal subunit (SSU) processome; ortholog of the human U3-55k protein" /db_xref="GeneID:856255" /db_xref="SGD:S000006341" ORIGIN 1 msdvtqqkkr krskgevnps kptvdeeitd pssnedeqle vsdeedales eeefegenpa 61 dkrrrlakqy lenlkseand iltdnrnaee kdlnnlkert ideynnfdag dldkdiiasr 121 lkedvaeqqg rvfryfgdkl liseakqsft rvgennltci scfqpvlnky tfeessngdk 181 nkgrlfaytv skdlqltkyd itdfskrpkk lkyakggaky iptskheyen tteghydeil 241 tvaaspdgky vvtggrdrkl ivwsteslsp vkviptkdrr gevlslafrk nsdqlyasca 301 dfkirtysin qfsqleilyg hhdivedisa lamercvtvg ardrtamlwk ipdetrltfr 361 ggdepqkllr rwmkenakeg edgevkypde seaplffceg sidvvsmvdd fhfitgsdng 421 niclwslakk kpifteriah gilpepsfnd isgetdeelr krqlqgkkll qpfwitslya 481 ipysnvfisg swsgslkvwk isdnlrsfel lgelsgakgv vtkiqvvesg khgkekfril 541 asiakehrlg rwianvsgar ngiysavidq tgf // LOCUS NP_058191 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058191 VERSION NP_058191.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184394.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11550. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198438" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1265..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YPR137C-B" /coded_by="join(NM_001184394.2:1..1305, NM_001184394.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:856257" /db_xref="SGD:S000007360" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqtaqshsp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksar qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskrvskt niraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysenetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdlppes 1141 ptefpdpfke lppinshqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmntwdtd kyydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydtgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 hyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniflln gkviggkstk asltctstte aeihavseai pllnnlshlv qelnkkpiik 1681 glltdsrsti siikstneek frnrffgtka mrlrdevsgn nlyvyyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_058192 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058192 VERSION NP_058192.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184393.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11551. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..440 /product="gag protein" /calculated_mol_wt="48941" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YPR137C-A" /coded_by="NM_001184393.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:856258" /db_xref="SGD:S000007359" ORIGIN 1 mesqqlsqhs pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqtaqshsp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_015464 489 aa linear PLN 30-JUN-2025 DEFINITION ammonium permease MEP3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015464 VERSION NP_015464.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184235.1 REFERENCE 1 (residues 1 to 489) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 489) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 489) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 489) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 489) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11552. Method: conceptual translation. FEATURES Location/Qualifiers source 1..489 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..489 /product="ammonium permease MEP3" /calculated_mol_wt="53559" Region 18..423 /region_name="amt" /note="ammonium transporter; TIGR00836" /db_xref="CDD:273292" CDS 1..489 /gene="MEP3" /locus_tag="YPR138C" /coded_by="NM_001184235.1:1..1470" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0008519 ammonium channel activity [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0008519 ammonium channel activity [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0019740 nitrogen utilization [PMID:9234685]" /experiment="EXISTENCE:mutant phenotype:GO:0072488 ammonium transmembrane transport [PMID:9234685]" /note="Ammonium permease of high capacity and low affinity; belongs to Mep-Amt-Rh family of well-conserved ammonium (NH4+) transporters that includes the human Rh factors; expression is under the nitrogen catabolite repression regulation ammonia permease activity regulated by TORC1 effectors, Npr1p and Par32p; MEP3 has a paralog, MEP1, that arose from the whole genome duplication" /db_xref="GeneID:856260" /db_xref="SGD:S000006342" ORIGIN 1 margdghlwt etydsstvaf milgaalvff mvpglgflys glarrksala liwvvimatl 61 vgilqwyfwg yslafsktat nnkfignlds fgfrnvygki sddstypeli yaifqmmfmc 121 valsiiagat aergklfphm vflfvfatlv ycpitywiwa pggwayqwgv ldwagggnie 181 ilsavagfvy syflgrrken llinfrphnv smvtlgtsil wfgwllfnaa sslspnmrsv 241 yafmntclsa ttggmtwcll dyrsekkwst vglcsgiicg lvaatpssgc itlygsliqg 301 iiagvvcnfa tkikyylkvd dsldllaehg iagvvglifn alfaadwvig mdgttkhkgg 361 wlthnwkqmy iqiayigasa gycavvtaii cfvlgkipgv hlrvteeaea lgldedqige 421 faydyvevrr dyyqwgvdtd alhttcngan sasetnpted sqnsslssat vsgqneksnn 481 pklhhakea // LOCUS NP_015465 300 aa linear PLN 30-JUN-2025 DEFINITION lysophosphatidic acid acyltransferase LOA1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015465 VERSION NP_015465.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184236.1 REFERENCE 1 (residues 1 to 300) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 300) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 300) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 300) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 300) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11553. Method: conceptual translation. FEATURES Location/Qualifiers source 1..300 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..300 /product="lysophosphatidic acid acyltransferase LOA1" /EC_number="2.3.1.51" /calculated_mol_wt="33685" CDS 1..300 /gene="LOA1" /locus_tag="YPR139C" /gene_synonym="VPS66" /coded_by="NM_001184236.1:1..903" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:22090344|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:22090344|PMID:21820081]" /experiment="EXISTENCE:direct assay:GO:0042171 lysophosphatidic acid acyltransferase activity [PMID:22090344]" /experiment="EXISTENCE:mutant phenotype:GO:0006623 protein targeting to vacuole [PMID:12134085]" /experiment="EXISTENCE:mutant phenotype:GO:0034389 lipid droplet organization [PMID:22090344]" /experiment="EXISTENCE:mutant phenotype:GO:0035356 intracellular triglyceride homeostasis [PMID:22090344]" /note="Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA" /db_xref="GeneID:856261" /db_xref="SGD:S000006343" ORIGIN 1 mekytnwrdn gtgiapflpn tirkpskvmt acllgilgvk tiimlpliml ylltgqnnll 61 glilkftfsw keeitvqgik krdvrkskhy pqkgklyicn ctspldafsv vllaqgpvtl 121 lvpsndivyk vsirefinfi laggldikly ghevaelsql gntvnfmfae gtscngksvl 181 pfsitgkklk efidpsittm npamaktkkf elqtiqiktn ktaittlpis nmeylsrfln 241 kginvkckin epqvlsdnle elrvalnggd kyklvsrkld veskrnfvke yisdqrkkrk // LOCUS NP_015466 381 aa linear PLN 30-JUN-2025 DEFINITION lysophosphatidylcholine acyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015466 VERSION NP_015466.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184237.1 REFERENCE 1 (residues 1 to 381) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 381) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 381) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 381) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 381) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11554. Method: conceptual translation. FEATURES Location/Qualifiers source 1..381 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..381 /product="lysophosphatidylcholine acyltransferase" /calculated_mol_wt="44057" Region 41..282 /region_name="LPLAT_AGPAT-like" /note="Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; cd07989" /db_xref="CDD:153251" Site order(77,80,82,105..108,190..192) /site_type="active" /note="putative acyl-acceptor binding pocket [active]" /db_xref="CDD:153251" CDS 1..381 /gene="TAZ1" /locus_tag="YPR140W" /coded_by="NM_001184237.1:1..1146" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:14562095|PMID:24769239|PMID:15304507|P MID:26928762|PMID:15588229|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16135531|PMID:16880272]" /experiment="EXISTENCE:direct assay:GO:0005743 mitochondrial inner membrane [PMID:16880272]" /experiment="EXISTENCE:direct assay:GO:0035965 cardiolipin acyl-chain remodeling [PMID:27268057]" /experiment="EXISTENCE:direct assay:GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity [PMID:27268057]" /experiment="EXISTENCE:mutant phenotype:GO:0005739 mitochondrion [PMID:15304507]" /experiment="EXISTENCE:mutant phenotype:GO:0007007 inner mitochondrial membrane organization [PMID:14651618]" /experiment="EXISTENCE:mutant phenotype:GO:0008654 phospholipid biosynthetic process [PMID:14651618|PMID:15588229]" /experiment="EXISTENCE:mutant phenotype:GO:0032048 cardiolipin metabolic process [PMID:14651618]" /experiment="EXISTENCE:mutant phenotype:GO:0035965 cardiolipin acyl-chain remodeling [PMID:14651618]" /experiment="EXISTENCE:mutant phenotype:GO:0042775 mitochondrial ATP synthesis coupled electron transport [PMID:15304507]" /experiment="EXISTENCE:mutant phenotype:GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity [PMID:15588229]" /experiment="EXISTENCE:mutant phenotype:GO:0097250 mitochondrial respirasome assembly [PMID:16135531]" /note="Lyso-phosphatidylcholine acyltransferase; required for normal phospholipid content of mitochondrial membranes; major determinant of the final acyl chain composition of the mitochondrial-specific phospholipid cardiolipin; mutations in human ortholog tafazzin (TAZ) cause Barth syndrome, a rare X-linked disease characterized by skeletal and cardiomyopathy and bouts of cyclic neutropenia; a specific splice variant of human TAZ can complement yeast null mutant" /db_xref="GeneID:856262" /db_xref="SGD:S000006344" ORIGIN 1 msfrdvlerg defleayprr splwrflsys tslltfgvsk lllftcynvk lngfekleta 61 lerskrenrg lmtvmnhmsm vddplvwatl pyklftsldn irwslgahni cfqnkflanf 121 fslgqvlste rfgvgpfqgs idasirllsp ddtldlewtp hsevssslkk aysppiirsk 181 pswvhvypeg fvlqlyppfe nsmryfkwgi trmileatkp pivvpifatg fekiaseavt 241 dsmfrqilpr nfgseinvti gdplnddlid ryrkewthlv ekyydpknpn dlsdelkygk 301 eaqdlrsrla aelrahvaei rnevrklpre dprfkspsww krfnttegks dpdvkvigen 361 wairrmqkfl ppegkpkgkd d // LOCUS NP_015467 729 aa linear PLN 30-JUN-2025 DEFINITION Kar3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015467 VERSION NP_015467.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184238.1 REFERENCE 1 (residues 1 to 729) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 729) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 729) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 729) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 729) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 729) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 729) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11555. Method: conceptual translation. FEATURES Location/Qualifiers source 1..729 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..729 /product="Kar3p" /EC_number="5.6.1.4" /calculated_mol_wt="83873" Region <83..389 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" Region 384..725 /region_name="KISc_C_terminal" /note="Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins; cd01366" /db_xref="CDD:276817" Site order(394,474,477,479..482,626) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:276817" Site order(676,679,682) /site_type="other" /note="microtubule interaction site [polypeptide binding]" /db_xref="CDD:276817" CDS 1..729 /gene="KAR3" /locus_tag="YPR141C" /gene_synonym="OSR11" /coded_by="NM_001184238.1:1..2190" /experiment="EXISTENCE:direct assay:GO:0000922 spindle pole [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:8106549|PMID:11729143|PMID:2138512]" /experiment="EXISTENCE:direct assay:GO:0005874 microtubule [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005881 cytoplasmic microtubule [PMID:2138512]" /experiment="EXISTENCE:direct assay:GO:0008017 microtubule binding [PMID:22734002]" /experiment="EXISTENCE:direct assay:GO:0008569 minus-end-directed microtubule motor activity [PMID:8041770]" /experiment="EXISTENCE:direct assay:GO:0044732 mitotic spindle pole body [PMID:16533946]" /experiment="EXISTENCE:direct assay:GO:0051321 meiotic cell cycle [PMID:11729143]" /experiment="EXISTENCE:genetic interaction:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0000278 mitotic cell cycle [PMID:9201713]" /experiment="EXISTENCE:mutant phenotype:GO:0000742 karyogamy involved in conjugation with cellular fusion [PMID:2138512]" /experiment="EXISTENCE:mutant phenotype:GO:0000743 nuclear migration involved in conjugation with cellular fusion [PMID:19386762|PMID:2138512|PMID:16380440]" /experiment="EXISTENCE:mutant phenotype:GO:0007064 mitotic sister chromatid cohesion [PMID:14742714]" /experiment="EXISTENCE:mutant phenotype:GO:0036503 ERAD pathway [PMID:39841550]" /experiment="EXISTENCE:mutant phenotype:GO:0051321 meiotic cell cycle [PMID:11729143]" /experiment="EXISTENCE:mutant phenotype:GO:0060236 regulation of mitotic spindle organization [PMID:25313961]" /note="Minus-end-directed microtubule motor; functions in mitosis and meiosis; localizes to the spindle pole body and localization is dependent on functional Cik1p; required for nuclear fusion during mating; required for ER-associated degradation (ERAD); potential Cdc28p substrate; kinesin 14 family member with a C-terminal motor domain" /db_xref="GeneID:856263" /db_xref="SGD:S000006345" ORIGIN 1 meslprtptk grstqhlstp spkndilamn ghkrrntttp ppkhtllkpq rtdihrhsla 61 sqsrismspn rellknykgt anliygnqks nsgvtsfyke nvnelnrtqa ilfekkatld 121 llkdeltetk ekinavnlkf etlreekiki eqqlnlknne lisikeefls kkqfmneghe 181 ihlkqlaasn kkelkqmene yktkieklkf mkikqfener aslldkieev rnkitmnpst 241 lqemlndveq khmlekeewl teyqsqwkkd ielnnkhmqe iesikkeien tlkpelaekk 301 klltekrnay eaikvkvkek eeettrlrde valkqktnle tlekikelee yikdtelgmk 361 elneilikee tvrrtlhnel qelrgnirvy crirpalknl ensdtslinv nefddnsgvq 421 smevtkiqnt aqvhefkfdk ifdqqdtnvd vfkevgqlvq ssldgynvci faygqtgsgk 481 tftmlnpgdg iipstishif nwinklktkg wdykvncefi eiynenivdl lrsdnnnked 541 tsiglkheir hdqetkttti tnvtsckles eemveiilkk anklrstast asnehssrsh 601 sifiihlsgs naktgahsyg tlnlvdlags erinvsqvvg drlretqnin kslsclgdvi 661 halgqpdstk rhipfrnskl tyllqysltg dsktlmfvni spssshinet lnslrfaskv 721 nstrlvsrk // LOCUS NP_015469 250 aa linear PLN 30-JUN-2025 DEFINITION rRNA-processing protein RRP15 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015469 VERSION NP_015469.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184240.1 REFERENCE 1 (residues 1 to 250) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 250) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 250) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 250) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 250) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11556. Method: conceptual translation. FEATURES Location/Qualifiers source 1..250 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..250 /product="rRNA-processing protein RRP15" /calculated_mol_wt="28081" Region 112..242 /region_name="Rrp15p" /note="pfam07890" /db_xref="CDD:462305" CDS 1..250 /gene="RRP15" /locus_tag="YPR143W" /coded_by="NM_001184240.1:1..753" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0030687 preribosome, large subunit precursor [PMID:15769876]" /experiment="EXISTENCE:mutant phenotype:GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15769876]" /experiment="EXISTENCE:mutant phenotype:GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15769876]" /note="Nucleolar protein; constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs" /db_xref="GeneID:856264" /db_xref="SGD:S000006347" ORIGIN 1 mgskhrvdtk dkkrtrknae fgrekrnsgn qelsnepekd timegdeaee deqnsssdes 61 skiidneqsd aeedddeeee dddfprkkks knskhddgst gfsaavnail sshlkaydrk 121 dpimarnkkv lkqsesekle ykakkallae kkkllgkark tdiipiasge drsenirkvl 181 eketalrkia qkgavklfna ilatqvktek evsenlseik nkeekkelit evskekfldl 241 vkaaagsdne // LOCUS NP_015470 552 aa linear PLN 30-JUN-2025 DEFINITION ribosome biosynthesis protein NOC4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015470 VERSION NP_015470.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184241.1 REFERENCE 1 (residues 1 to 552) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 552) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 552) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 552) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 552) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11557. Method: conceptual translation. FEATURES Location/Qualifiers source 1..552 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..552 /product="ribosome biosynthesis protein NOC4" /calculated_mol_wt="63506" Region 317..480 /region_name="CBF" /note="CBF/Mak21 family; pfam03914" /db_xref="CDD:461090" CDS 1..552 /gene="NOC4" /locus_tag="YPR144C" /gene_synonym="UTP19" /coded_by="NM_001184241.1:1..1659" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:10684247]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:12150911|PMID:12446671|PMID:15590835]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0030686 90S preribosome [PMID:12150911]" /experiment="EXISTENCE:direct assay:GO:0032040 small-subunit processome [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [PMID:15590835]" /experiment="EXISTENCE:mutant phenotype:GO:0006364 rRNA processing [PMID:12446671]" /experiment="EXISTENCE:mutant phenotype:GO:0042274 ribosomal small subunit biogenesis [PMID:12446671]" /experiment="EXISTENCE:physical interaction:GO:0030692 Noc4p-Nop14p complex [PMID:12446671]" /note="Nucleolar protein; forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:856267" /db_xref="SGD:S000006348" ORIGIN 1 mvlliseikd iakrltaagd rkqynsiikl inelvipenv tqleedetek nlrflvmslf 61 qifrklfsrg dltlpsskks tlekeqfvnw crkvyeafkt kllaiisdip fetslgldsl 121 dvylqlaele sthfasekga pffpnktfrk liialwssnm geiedvkssg asenliivef 181 tekyytkfad iqyyfqsefn qlledpayqd lllknvgkwl alvnhdkhcs svdadleifv 241 pnppqaiene skfksnfekn wlsllngqls lqqyksilli lhkriiphfh tptklmdflt 301 dsynlqssnk nagvvpilal nglfelmkrf nleypnfymk lyqiinpdlm hvkyrarffr 361 lmdvflssth lsahlvasfi kklarltles ppsaivtvip fiynlirkhp ncmimlhnpa 421 fisnpfqtpd qvanlktlke nyvdpfdvhe sdpelthald sslwelaslm ehyhpnvatl 481 akifaqpfkk lsynmedfld wnydsllnae ssrklktlpt lefeaftnvf dnedgdseas 541 sqgnvylpgv aw // LOCUS NP_015471 572 aa linear PLN 30-JUN-2025 DEFINITION asparagine synthase (glutamine-hydrolyzing) 1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015471 VERSION NP_015471.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184242.1 REFERENCE 1 (residues 1 to 572) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 572) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 572) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 572) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 572) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11558. Method: conceptual translation. FEATURES Location/Qualifiers source 1..572 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..572 /product="asparagine synthase (glutamine-hydrolyzing) 1" /EC_number="6.3.5.4" /calculated_mol_wt="64339" Region 1..562 /region_name="asnB" /note="asparagine synthetase B; Provisional; PRK09431" /db_xref="CDD:236513" CDS 1..572 /gene="ASN1" /locus_tag="YPR145W" /coded_by="NM_001184242.1:1..1719" /experiment="EXISTENCE:direct assay:GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity [PMID:6105958]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:genetic interaction:GO:0006529 asparagine biosynthetic process [PMID:8951815]" /note="Asparagine synthetase; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway; ASN1 has a paralog, ASN2, that arose from the whole genome duplication" /db_xref="GeneID:856268" /db_xref="SGD:S000006349" ORIGIN 1 mcgifaafrh edvhrykpka lqlskrirhr gpdwsgnaik nstifvherl aivgvesgaq 61 pitssdgeym lcvngeiynh iqlreecady efgtlsdcep iipmylkhdi dapkyldgmf 121 awtlydakqd rivaardpig ittlymgrss aspktvyfas elkcltddcd titafppghv 181 ydsktdkitr yftpdwldek ripstpidym airhslekav rkrlmaevpy gvllsgglds 241 sliasiaare takatndvep stydskarhl agidddgklh tagwtslhsf aiglpnapdl 301 qaarkvakfi gsihhehtft lqegldaldd viyhletydv ttirastpmf llsrkikaqg 361 vkmvlsgegs deifggylyf aqapsaaefh tesvqrvknl hladclrank stmawglear 421 vpfldreflq lcmnidpnek mikpkegrie kyilrkafdt tgepdakpyl peeilwrqke 481 qfsdgvgysw idglkdtaea visdemfasp kaewgsdipt tkeafwyrlk fdalfpqktv 541 adtvmrwipk adwgcaedps gryaqihekh ie // LOCUS NP_001032572 78 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR145C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_001032572 VERSION NP_001032572.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184687.1 REFERENCE 1 (residues 1 to 78) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 78) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 78) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 78) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 78) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11559. Method: conceptual translation. FEATURES Location/Qualifiers source 1..78 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..78 /product="uncharacterized protein" /calculated_mol_wt="9117" CDS 1..78 /locus_tag="YPR145C-A" /coded_by="NM_001184687.1:1..237" /note="hypothetical protein" /db_xref="GeneID:3799978" /db_xref="SGD:S000113589" ORIGIN 1 mstafrkikl ifkksdsqyp qnyraeiksr nkntvitrhd lliahemkqr aslersnsir 61 nlqsqgkrrs dskesrkl // LOCUS NP_015473 304 aa linear PLN 30-JUN-2025 DEFINITION bifunctional triacylglycerol lipase/ester hydrolase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015473 VERSION NP_015473.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184244.1 REFERENCE 1 (residues 1 to 304) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 304) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 304) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 304) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 304) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11560. Method: conceptual translation. FEATURES Location/Qualifiers source 1..304 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..304 /product="bifunctional triacylglycerol lipase/ester hydrolase" /EC_number="3.1.1.3" /calculated_mol_wt="34711" Region 30..292 /region_name="LIDHydrolase" /note="Lipid-droplet associated hydrolase; pfam10230" /db_xref="CDD:370901" CDS 1..304 /locus_tag="YPR147C" /coded_by="NM_001184244.1:1..915" /experiment="EXISTENCE:direct assay:GO:0004806 triacylglycerol lipase activity [PMID:29491250]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005811 lipid droplet [PMID:24868093]" /experiment="EXISTENCE:direct assay:GO:0016788 hydrolase activity, acting on ester bonds [PMID:29491250]" /experiment="EXISTENCE:mutant phenotype:GO:0006629 lipid metabolic process [PMID:29491250]" /experiment="EXISTENCE:mutant phenotype:GO:0019433 triglyceride catabolic process [PMID:29491250]" /note="Bifunctional triacylglycerol lipase and short chain ester hydrolase; null mutant results in the accumulation of both triacylglycerol and fatty acids derived from neutral lipids and phospholipids as well as an increase in the quantity of lipid droplets; contains an alpha/beta hydrolase domain with a conserved GXSXG lipase motif; localizes to lipid droplets; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS" /db_xref="GeneID:856270" /db_xref="SGD:S000006351" ORIGIN 1 mtvkeytksk lpcsilnikp tvtksgedap llvwipgnpg llyyyqemlh hlhlkhpdwe 61 ilgishagmt lnahsntpif slqdqvdhqv evinnfsckn rkiiimghsv gayivqkvcl 121 snklvgsvqk vglvtptvmd ihtsemgikm taalryippl ahvvslfsyi ffywilsegf 181 srfiidkfmg cgstgyqavl striflthrq fvrqslglaa qemeeittnw efqdrfinyc 241 eengisiwfl fssndhwvsg ktrshlsdyy kdkvkqerlk idvtdkiphs fvvkhaeyai 301 naff // LOCUS NP_015474 435 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR148C [Saccharomyces cerevisiae S288C]. ACCESSION NP_015474 VERSION NP_015474.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184245.1 REFERENCE 1 (residues 1 to 435) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 435) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 435) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 435) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 435) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11561. Method: conceptual translation. FEATURES Location/Qualifiers source 1..435 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..435 /product="uncharacterized protein" /calculated_mol_wt="49148" Region 44..432 /region_name="BAR_2" /note="Bin/amphiphysin/Rvs domain for vesicular trafficking; pfam10455" /db_xref="CDD:402196" Site order(110,113..114,119..120,123..124,126..127,144..145, 147..148,151..152,154..155,158,221,224..225,393,396..397, 399,402,405..406,408..409,412..413,416..417,419..420, 423..424,426..427) /site_type="other" /note="dimer interface [polypeptide binding]" /db_xref="CDD:153271" Region 230..>363 /region_name="PspC_subgroup_1" /note="pneumococcal surface protein PspC, choline-binding form; NF033838" /db_xref="CDD:468201" CDS 1..435 /locus_tag="YPR148C" /coded_by="NM_001184245.1:1..1308" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095]" /note="hypothetical protein; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern" /db_xref="GeneID:856271" /db_xref="SGD:S000006352" ORIGIN 1 msgyfsgfsl nkitdsiata ahktqdtlnn alananvnln dpqtrlsiks rtrfvqeslg 61 tvsdisklpp qyqflekksd slekvckril lvsktfeveg ydyppnltes isdwwslnkd 121 gwfgskkses stkkkgsnhd daflprsfaq aiskaavdce cefqnlehne kaelkkkkes 181 iktaqtteaq gadhneedee deedeedded lsnlikvfds wstcyknide gkaemdsmmv 241 kefnkkletl inqdfkkvhd lrkkveesrl kfdtmryevk akeaeleakk aeatgeahsk 301 dvsakdisan tttsfdetps tedekpkseg aeeeskkean eptvddvadr kedlksnkvn 361 deppieesed nklleklede fvsnttaave tmeeitdsse ilgliklfqn fqlvyfrqcv 421 qeveanlkvl nglei // LOCUS NP_015475 173 aa linear PLN 30-JUN-2025 DEFINITION Nce102p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015475 VERSION NP_015475.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184246.1 REFERENCE 1 (residues 1 to 173) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 173) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 173) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 173) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 173) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11562. Method: conceptual translation. FEATURES Location/Qualifiers source 1..173 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..173 /product="Nce102p" /calculated_mol_wt="18836" Region 2..140 /region_name="MARVEL" /note="Membrane-associating domain; pfam01284" /db_xref="CDD:366555" CDS 1..173 /gene="NCE102" /locus_tag="YPR149W" /gene_synonym="NCE2" /coded_by="NM_001184246.1:1..522" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12469340|PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0033101 cellular bud membrane [PMID:19064668]" /experiment="EXISTENCE:direct assay:GO:0070250 mating projection membrane [PMID:19064668]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:genetic interaction:GO:0061091 regulation of phospholipid translocation [PMID:27033517]" /experiment="EXISTENCE:mutant phenotype:GO:0001933 negative regulation of protein phosphorylation [PMID:19564405]" /experiment="EXISTENCE:mutant phenotype:GO:0007009 plasma membrane organization [PMID:19564405]" /experiment="EXISTENCE:mutant phenotype:GO:0009306 protein secretion [PMID:8655575]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:27033517]" /experiment="EXISTENCE:mutant phenotype:GO:0070941 eisosome assembly [PMID:19564405|PMID:38096056]" /experiment="EXISTENCE:mutant phenotype:GO:0072659 protein localization to plasma membrane [PMID:20581291]" /experiment="EXISTENCE:mutant phenotype:GO:0097576 vacuole fusion [PMID:33114062]" /note="Protein involved in regulation of pheromone response and mating; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs); NCE102 has a paralog, FHN1, that arose from the whole genome duplication" /db_xref="GeneID:856272" /db_xref="SGD:S000006353" ORIGIN 1 mlaladnilr iinflflvis iglissllnt qhrhssrvny cmfacaygif tdslygvfan 61 fieplawplv lftldflnfv ftftagtvla vgirahscnn ssyvdsnkit qgsgtrcrqa 121 qaavaflyfs caiflaktlm svfnmisnga fgsgsfskrr rtgqvgvpti sqv // LOCUS NP_015477 206 aa linear PLN 30-JUN-2025 DEFINITION Sue1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015477 VERSION NP_015477.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184248.1 REFERENCE 1 (residues 1 to 206) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 206) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 206) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 206) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 206) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11563. Method: conceptual translation. FEATURES Location/Qualifiers source 1..206 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..206 /product="Sue1p" /calculated_mol_wt="24174" Region 58..191 /region_name="Pet20" /note="Mitochondrial protein Pet20; pfam08692" /db_xref="CDD:400848" CDS 1..206 /gene="SUE1" /locus_tag="YPR151C" /coded_by="NM_001184248.1:1..621" /experiment="EXISTENCE:direct assay:GO:0005740 mitochondrial envelope [PMID:15123691]" /experiment="EXISTENCE:mutant phenotype:GO:0030163 protein catabolic process [PMID:15123691]" /note="Protein required for degradation of unstable forms of cytochrome c; located in the mitochondria" /db_xref="GeneID:856274" /db_xref="SGD:S000006355" ORIGIN 1 millkrtkir gvsvsfvslq rrthsrlvnp irqqhqqitk qrsskilkna hfydfrslpk 61 vpttqylear eltrdilysg yrpvmypvke nplfrdkkrk slqtlltmne ktnaeaktid 121 ekkhknilfg ergtggimsg gvngtwkynp tvpnellpfn wwstssmgme yfpewknvpp 181 ymmrklkpfd kalqmrlthk skkkmk // LOCUS NP_015478 465 aa linear PLN 30-JUN-2025 DEFINITION Urn1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015478 VERSION NP_015478.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184249.1 REFERENCE 1 (residues 1 to 465) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 465) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 465) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 465) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11564. Method: conceptual translation. FEATURES Location/Qualifiers source 1..465 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..465 /product="Urn1p" /calculated_mol_wt="54008" Region 2..>88 /region_name="PRP40" /note="Splicing factor [RNA processing and modification]; COG5104" /db_xref="CDD:227435" Region 5..30 /region_name="WW" /note="WW domain; pfam00397" /db_xref="CDD:459800" Region 219..263 /region_name="FF" /note="FF domain; pfam01846" /db_xref="CDD:426471" CDS 1..465 /gene="URN1" /locus_tag="YPR152C" /coded_by="NM_001184249.1:1..1398" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0071010 prespliceosome [PMID:19941820]" /note="hypothetical protein containing WW and FF domains; overexpression causes accumulation of cells in G1 phase" /db_xref="GeneID:856275" /db_xref="SGD:S000006356" ORIGIN 1 mrgewqefkt pagkkyyynk ntkqsrwekp nlkkgsnles nakesqterk ptfslelvng 61 whliiyndgt klyfnddske fkndisqedd srcrsliesl dkeklvllig vargytmree 121 didkilescn eeihlfkrnq deverkdeis eeagdvkspl qeshtglvsg ygsssgeede 181 eedeeedeen eeqivnqdis iiddlnridt ddiderniff elfdrykldk fstwslqskk 241 iendpdfyki rddtvreslf eewcgersgn ataeesdsed nseddsevle ptkyhylaqi 301 vanagtiapd tipqdirkqq kalykaykik eyipskrdqd kfvsqllfyy ktfdleqrke 361 ifcdclrdhe rdftgavesl rqdkelidrw qtllkapads ssiedillsi ehrccvspiv 421 vtepryyvvg ilektvvwvr wlaaevgpss rftpvgagne pinpe // LOCUS NP_015479 140 aa linear PLN 30-JUN-2025 DEFINITION May24p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015479 VERSION NP_015479.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184250.1 REFERENCE 1 (residues 1 to 140) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 140) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 140) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 140) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 140) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11565. On Jul 30, 2007 this sequence version replaced NP_015479.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..140 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..140 /product="May24p" /calculated_mol_wt="15646" Region 36..134 /region_name="Tmemb_170" /note="Putative transmembrane protein 170; pfam10190" /db_xref="CDD:462988" CDS 1..140 /gene="MAY24" /locus_tag="YPR153W" /gene_synonym="EHG1" /coded_by="NM_001184250.1:1..423" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:31797992]" /experiment="EXISTENCE:mutant phenotype:GO:0071464 cellular response to hydrostatic pressure [PMID:31797992]" /note="Peripheral ER membrane protein; putative ER chaperone required for the stability and function of nutrient permeases exposed to high pressure" /db_xref="GeneID:856276" /db_xref="SGD:S000006357" ORIGIN 1 mrsfvtnndi pvgyvtpkfp slywpinnsk yntaflyyis diwkfslywt lifngafyvt 61 agvyaslthr kkagsvwifv myvlyggvqg lttgtvmgfl igaiyrsglf smstwvplcc 121 avvqilfdvv lsysmvgsvm // LOCUS NP_015480 215 aa linear PLN 30-JUN-2025 DEFINITION Pin3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015480 VERSION NP_015480.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184251.1 REFERENCE 1 (residues 1 to 215) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 215) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 215) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 215) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 215) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11566. Method: conceptual translation. FEATURES Location/Qualifiers source 1..215 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..215 /product="Pin3p" /calculated_mol_wt="23408" Region 58..110 /region_name="SH3" /note="Src Homology 3 domain superfamily; cl17036" /db_xref="CDD:473055" Site order(63,65,68,72,90..91,104,106..107) /site_type="other" /note="peptide ligand binding site [polypeptide binding]" /db_xref="CDD:212690" CDS 1..215 /gene="PIN3" /locus_tag="YPR154W" /gene_synonym="LSB2" /coded_by="NM_001184251.1:1..648" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:23577202]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:23577202]" /experiment="EXISTENCE:direct assay:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:23577202]" /experiment="EXISTENCE:physical interaction:GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation [PMID:23577202]" /note="Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication" /db_xref="GeneID:856277" /db_xref="SGD:S000006358" ORIGIN 1 msaslinrsl tnirteldfl kgsnvisndv ydqinkslpa kwdpanaprn aspasleyve 61 alyqfdpqqd gdlglkpgdk vqlleklspe wykgscngrt gifpanyvkp afsgsngpsn 121 lppppqykaq elqqiptqns aassyqqqpf pppstnyyqq pqqqpqqapp pqqqqqqqqh 181 qsshshlksf gsklgnaaif gagasigsdi vnnif // LOCUS NP_015481 616 aa linear PLN 30-JUN-2025 DEFINITION Nca2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015481 VERSION NP_015481.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184252.1 REFERENCE 1 (residues 1 to 616) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 616) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 616) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 616) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 616) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11567. Method: conceptual translation. FEATURES Location/Qualifiers source 1..616 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..616 /product="Nca2p" /calculated_mol_wt="70731" Region 329..610 /region_name="NCA2" /note="ATP synthase regulation protein NCA2; pfam08637" /db_xref="CDD:430121" CDS 1..616 /gene="NCA2" /locus_tag="YPR155C" /coded_by="NM_001184252.1:1..1851" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239|PMID:14576278|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:7723016]" /experiment="EXISTENCE:mutant phenotype:GO:0016071 mRNA metabolic process [PMID:7723016]" /note="Protein that regulates expression of Fo-F1 ATP synthase subunits; involved in the regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p" /db_xref="GeneID:856278" /db_xref="SGD:S000006359" ORIGIN 1 miinrrilks feeishslee slrevafdsq qqliqdvree neelsrlqdq lqlirsivek 61 icisiktdni dsycsvpfdl lynickdiad pssfedgdlq ylvsqaifey iillcyysvt 121 necvqglpav yeaeqyyktv sdsilksfly clqnsvstir llsqtvlkdv nkkklshqkw 181 slkalsvdll ekirprinkf mvirnfrfvg lpkkpieias lvsdiprgiv herldmvtqs 241 skyytiklgq litefdqqpe engmftevhl pnyerrlksl qdffglamsd snlldvircs 301 akfhkdhplr rftkpsiltr ywpsillcll ygpssvmslw nsryfiqdfi ktnvvdfakg 361 lilnwlwapl kqvwstvkhd egsaisvtsq etlnsdmdsl trmivsfvvd nsdstsnspi 421 dpillstkve hgdltefmei yetqlhhpik niatgglvrs lliqlqktkv dgsmalngid 481 kmlksqqlvf gvvalspalv ilyssivalk rfvklgnvws nekryreqis islnnvervl 541 nyskqgadad eehlnqgllv ievsnlyklg sfliprsrkk ewfrdveelv dtnldsgahi 601 nvvnriyhvy grflih // LOCUS NP_015482 622 aa linear PLN 30-JUN-2025 DEFINITION spermine transporter [Saccharomyces cerevisiae S288C]. ACCESSION NP_015482 VERSION NP_015482.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184253.1 REFERENCE 1 (residues 1 to 622) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 622) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 622) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 622) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 622) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11568. Method: conceptual translation. FEATURES Location/Qualifiers source 1..622 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..622 /product="spermine transporter" /calculated_mol_wt="67935" Region 182..608 /region_name="MFS_Tpo1_MDR_like" /note="Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17323" /db_xref="CDD:340881" Site order(192..193,196..197,200,232,282..283,285..287,290,310, 313..314,317,419,422..423,426..428,431,455,459,528..529, 533,537,552,555..556,559..560,563) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:340881" CDS 1..622 /gene="TPO3" /locus_tag="YPR156C" /coded_by="NM_001184253.1:1..1869" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:12562762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0000296 spermine transport [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0000297 spermine transmembrane transporter activity [PMID:11171066]" /experiment="EXISTENCE:mutant phenotype:GO:0000329 fungal-type vacuole membrane [PMID:11171066]" /note="Polyamine transporter of major facilitator superfamily; member of 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to plasma membrane; targeted to vacuole via AP-3 pathway; TPO3 has a paralog, TPO2, that arose from the whole genome duplication" /db_xref="GeneID:856279" /db_xref="SGD:S000006360" ORIGIN 1 mnrqesinsf nsdetsslsd vesqqpqqyi psesgsksnm apnqlkltrt etvkslqdmg 61 vsskapvpdv napqssknki fpeeytletp tglvpvatlh sigrtstais rtrtrqidga 121 sspssnedal esdnnekgke gdssgandea pdldpeiefv tfvtgdpenp hnwpawirws 181 ytvllsilvi cvaygsacis gglgtvekky hvgmeaails vslmvigfsl gpliwspvsd 241 lygrrvayfv smglyvifni pcalapnlgs llacrflcgv wsssglclvg gsiadmfpse 301 trgkaiaffa fapyvgpvvg plvngfisvs tgrmdlifwv nmafagvmwi issaipetya 361 pvilkrkaar lrketgnpki mteqeaqgvs mgemmracll rplyfsvtep vlvatcfyvc 421 liysllyaff fafpvifgel ygykdnlvgl mfipivigal walattfyce nkylqivkqr 481 kptpedrllg akigapfaai alwilgatay khiiwvgpas aglafgfgmv liyyslnnyi 541 idcyvqyass alatkvflrs aggaafplft iqmyhklnlh wgswllafis tamialpfaf 601 sywgkglrhk lskkdysids ie // LOCUS NP_015483 467 aa linear PLN 30-JUN-2025 DEFINITION Tda6p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015483 VERSION NP_015483.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184254.1 REFERENCE 1 (residues 1 to 467) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 467) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 467) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 467) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 467) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11569. Method: conceptual translation. FEATURES Location/Qualifiers source 1..467 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..467 /product="Tda6p" /calculated_mol_wt="53678" CDS 1..467 /gene="TDA6" /locus_tag="YPR157W" /coded_by="NM_001184254.1:1..1404" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /note="hypothetical protein; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole; TDA6 has a paralog, VPS62, that arose from the whole genome duplication" /db_xref="GeneID:856280" /db_xref="SGD:S000006361" ORIGIN 1 mhcvlarill wflivdlsvi ralvlpplkd ydpleplmkr dmamgqrnrf kvdgqlppil 61 nstdvtddqr slhtpgeips yvinhcplvh lyseekywps diaeyvqnfq ikdkngnsis 121 thenltlhdl kaeyhvdlfg nktethipss evfltslddf dkdpkwllgh lpeygtgyns 181 kapailivvd kgngwvdafw fffypfnhgp fimghgpwgn hvgdwehslv rfykgipkyl 241 wmsahssgtg yryeavekfk klrkrkqqds ddggdtiler plifsargth anyasagqha 301 hdipfffmpl sdftdrgplw dpslnfysyt fdgktvtpss ereeslgldw lhfqggwgdq 361 qlpardprqk wcvaqwkyig gprgplfkkl drlnlcggvk kwnfwnggcp arrlikkaeg 421 ldsestdlmg dncgvllyri rpkwlrgilr flmwrgilcs lmefftn // LOCUS NP_015484 252 aa linear PLN 30-JUN-2025 DEFINITION Cur1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015484 VERSION NP_015484.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184255.1 REFERENCE 1 (residues 1 to 252) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 252) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 252) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 252) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 252) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11570. Method: conceptual translation. FEATURES Location/Qualifiers source 1..252 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..252 /product="Cur1p" /calculated_mol_wt="29032" CDS 1..252 /gene="CUR1" /locus_tag="YPR158W" /coded_by="NM_001184255.1:1..759" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22718905|PMID:18833194]" /experiment="EXISTENCE:genetic interaction:GO:0006457 protein folding [PMID:22718905]" /experiment="EXISTENCE:mutant phenotype:GO:0006457 protein folding [PMID:22718905]" /experiment="EXISTENCE:mutant phenotype:GO:0006886 intracellular protein transport [PMID:22718905]" /experiment="EXISTENCE:mutant phenotype:GO:0034504 protein localization to nucleus [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0006457 protein folding [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0006886 intracellular protein transport [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0034504 protein localization to nucleus [PMID:22718905]" /experiment="EXISTENCE:physical interaction:GO:0051087 protein-folding chaperone binding [PMID:22718905]" /note="Sorting factor, central regulator of spatial protein quality control; physically and functionally interacts with chaperones to promote sorting and deposition of misfolded proteins into cytosolic compartments; involved in destabilization of [URE3] prions; CUR1 has a paralog, BTN2, that arose from the whole genome duplication" /db_xref="GeneID:856281" /db_xref="SGD:S000006362" ORIGIN 1 maaacicqpn lleinvsdgp ldmirkkrki qqpqlrpplr enkcqphfsv rkvnqsyiis 61 lhkeitcqli aeivkqklsr iwekvyipsy elisdkdgnq iyveqsvden rltseimekl 121 dpnnidieai eilfddyhle lsrltngiii ssandhfyre fsfnniiddn fkicgtsmsa 181 dsfdkiygvm wievpfngng lqndsavnrv stshnqieel ndieqeiraf nisrsnqesi 241 ikkevsrrln gr // LOCUS NP_058193 1756 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058193 VERSION NP_058193.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184398.2 REFERENCE 1 (residues 1 to 1756) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1756) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1756) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1756) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1756) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1756) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1756) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11571. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1756 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1756 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198508" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..766 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1266..1499 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1607..1743 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1611..1614,1648..1650,1653,1686,1713,1740) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1756 /locus_tag="YPR158W-B" /coded_by="join(NM_001184398.2:1..1305, NM_001184398.2:1307..5272)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:856283" /db_xref="SGD:S000007364" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr pitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqklt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivky gdfywvskky llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekkngitpcy tttadsrahg vaerlnrtll 781 ddcrtqlqcs glpnhlwfsa iefstivrns laspkskksa rqhaglagld istllpfgqp 841 vivndhnpns kihprgipgy alhpsrnsyg yiiylpslkk tvdttnyvil qgkesrldqf 901 nydaltfded lnrltasyhs fiasneiqes ndlniesdhd fqsdielhpe qprnvlskav 961 sptdstppst htedskrvsk tniraprevd pnisesnilp skkrsstpqi sniestgsgg 1021 mhklnvplla pmsqsnthes shaskskdfr hsdsysenet nhtnvpisst ggtnnktvpq 1081 isdqetekri ihrspsidas ppennsshni vpiktpttvs eqnteesiia dlplpdlppe 1141 sptefpdpfk elppinshqt nsslggigds nayttinskk rslednetei kvsrdtwntk 1201 nmrslepprs kkrihliaav kavksikpir ttlrydeait ynkdikekek yieayhkevn 1261 qllkmntwdt dkyydrkeid pkrvinsmfi fnrkrdgthk arfvargdiq hpdtydsgmq 1321 sntvhhyalm tslslaldnn yyitqldiss aylyadikee lyirppphlg mndklirlkk 1381 slyglkqsga nwyetiksyl ikqcgmeevr gwscvfknsq vticlfvddm ilfskdlnan 1441 kkiittlkkq ydtkiinlge sdneiqydil gleikyqrgk ymklgmensl tekipklnvp 1501 lnpkgrklsa pgqpglyidq deleidedey kekvhemqkl iglasyvgyk frfdllyyin 1561 tlaqhilfps rqvldmtyel iqfmwdtrdk qliwhknkpt epdnklvais dasygnqpyy 1621 ksqigniyll ngkviggkst kasltctstt eaeihaises vpllnnlshl vqelnkkpit 1681 kglltdskst isiiisnnee kfrnrffgtk amrlrdevsg nhlhvcyiet kkniadvmtk 1741 plpiktfkll tnkwih // LOCUS NP_058194 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058194 VERSION NP_058194.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184397.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11572. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..440 /product="gag protein" /calculated_mol_wt="48967" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YPR158W-A" /coded_by="NM_001184397.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:856282" /db_xref="SGD:S000007363" ORIGIN 1 mesqqlsnyp hishgsacas vtskevhtnq dpldvsaski qeydkastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr pitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnpsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpety // LOCUS NP_058195 1755 aa linear PLN 30-JUN-2025 DEFINITION gag-pol fusion protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058195 VERSION NP_058195.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184396.2 REFERENCE 1 (residues 1 to 1755) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1755) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1755) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1755) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1755) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11573. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1755 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1755 /product="gag-pol fusion protein" /EC_number="2.7.7.7" /EC_number="2.7.7.49" /EC_number="3.1.26.4" /calculated_mol_wt="198244" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" Region 664..765 /region_name="rve" /note="Integrase core domain; pfam00665" /db_xref="CDD:459897" Region 1280..1498 /region_name="RVT_2" /note="Reverse transcriptase (RNA-dependent DNA polymerase); pfam07727" /db_xref="CDD:400190" Region 1606..1742 /region_name="RNase_HI_RT_Ty1" /note="Ty1/Copia family of RNase HI in long-term repeat retroelements; cd09272" /db_xref="CDD:260004" Site order(1610..1613,1647..1649,1652,1685,1712,1739) /site_type="other" /note="RNA/DNA hybrid binding site [nucleotide binding]" /db_xref="CDD:260004" CDS 1..1755 /locus_tag="YPR158C-D" /coded_by="join(NM_001184396.2:1..1305, NM_001184396.2:1307..5269)" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:9448009]" /ribosomal_slippage="" /note="Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes" /db_xref="GeneID:856284" /db_xref="SGD:S000007362" ORIGIN 1 mesqqlsnys pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlgqelt estvnhtnhs ddelpghlll dsgasrtlir sahhihsass 481 npdinvvdaq krnipinaig dlqfhfqdnt ktsikvlhtp niaydllsln elaavditac 541 ftknvlersd gtvlapivqy gdfywvskry llpsnisvpt innvhtsest rkypypfihr 601 mlahanaqti ryslknntit yfnesdvdws saidyqcpdc ligkstkhrh ikgsrlkyqn 661 syepfqylht difgpvhnlp ksapsyfisf tdettkfrwv yplhdrreds ildvfttila 721 fiknqfqasv lviqmdrgse ytnrtlhkfl ekngitpcyt ttadsrahgv aerlnrtlld 781 dcrtqlqcsg lpnhlwfsai efstivrnsl aspkskksas qhaglagldi stllpfgqpv 841 ivndhnpnsk ihprgipgya lhpsrnsygy iiylpslkkt vdttnyvilq gkesrldqfn 901 ydaltfdedl nrltasyhsf iasneiqesn dlniesdhdf qsdielhpeq prnvlskavs 961 ptdstppsth tedskpisei nlraprevdp nisesnilps kkrsstpqis niestgsggm 1021 hklnvpllap msqsnthess haskskdfrh sdsysnnetn htnvpisstg gtnnktvpqi 1081 sdqetekrii hrspsidasp pennsshniv piktpttvse qnteesiiad lplpdpppep 1141 ptelsdsfke lppinsrqtn sslggigdsn ayttinskkr sledneteik vsrdtwntkn 1201 mrslepprsk krihliaavk avksikpirt tlrydeaity nkdikekeky ieayhkevnq 1261 llkmktwdtd ryydrkeidp krvinsmfif nkkrdgthka rfvargdiqh pdtydtgmqs 1321 ntvhhyalmt slslaldnny yitqldissa ylyadikeel yirppphlgm ndklirlkks 1381 hyglkqsgan wyetiksyli kqcgmeevrg wscvfknsqv ticlfvddmi lfskdlnank 1441 kiittlkkqy dtkiinlges dneiqydilg leikyqrgky mklgmenslt ekipklnvpl 1501 npkgrklsap gqpglyidqd eleidedeyk ekvhemqkli glasyvgykf rfdllyyint 1561 laqhilfpsr qvldmtyeli qfmwdtrdkq liwhknkpte pdnklvaisd asygnqpyyk 1621 sqigniylln gkviggkstk asltctstte aeihaisesv pllnnlshlv qelnkkpitk 1681 glltdsksti siiisnneek frnrffgtka mrlrdevsgn hlhvcyietk kniadvmtkp 1741 lpiktfkllt nkwih // LOCUS NP_058196 440 aa linear PLN 30-JUN-2025 DEFINITION gag protein [Saccharomyces cerevisiae S288C]. ACCESSION NP_058196 VERSION NP_058196.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184395.1 REFERENCE 1 (residues 1 to 440) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 440) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 440) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 440) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 440) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11574. Method: conceptual translation. FEATURES Location/Qualifiers source 1..440 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..440 /product="gag protein" /calculated_mol_wt="48834" Region 17..400 /region_name="TYA" /note="Ty transposon capsid protein; pfam01021" /db_xref="CDD:425992" CDS 1..440 /locus_tag="YPR158C-C" /coded_by="NM_001184395.1:1..1323" /note="Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag" /db_xref="GeneID:856285" /db_xref="SGD:S000007361" ORIGIN 1 mesqqlsnys pishgsacas vtskevhtnq dpldvsaskt eecekastka nsqqtttpas 61 savpenphha spqpasvppp qngpypqqcm mtqnqanpsg wsfyghpsmi pytpyqmspm 121 yfppgpqsqf pqypssvgtp lstpspesgn tftdsssads dmtstkkyvr pppmltspnd 181 fpnwvktyik flqnsnlggi iptvngkpvr qitddeltfl yntfqifaps qflptwvkdi 241 lsvdytdimk ilsksiekmq sdtqeandiv tlanlqyngs tpadafetkv tniidrlnnn 301 gihinnkvac qlimrglsge ykflrytrhr hlnmtvaelf ldihaiyeeq qgsrnskpny 361 rrnlsdeknd srsytnttkp kviarnpqkt nnsksktara hnvstsnnsp stdndsisks 421 ttepiqlnnk hdlhlrpgty // LOCUS NP_015485 720 aa linear PLN 30-JUN-2025 DEFINITION beta-glucan synthesis-associated protein KRE6 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015485 VERSION NP_015485.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184256.1 REFERENCE 1 (residues 1 to 720) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 720) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 720) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 720) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 720) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11575. Method: conceptual translation. FEATURES Location/Qualifiers source 1..720 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..720 /product="beta-glucan synthesis-associated protein KRE6" /calculated_mol_wt="79992" Region 209..711 /region_name="SKN1_KRE6_Sbg1" /note="Beta-glucan synthesis-associated protein SKN1/KRE6/Sbg1; pfam03935" /db_xref="CDD:397841" CDS 1..720 /gene="KRE6" /locus_tag="YPR159W" /gene_synonym="CWH48" /coded_by="NM_001184256.1:1..2163" /experiment="EXISTENCE:direct assay:GO:0005789 endoplasmic reticulum membrane [PMID:17893149]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:21193403]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:7929594]" /experiment="EXISTENCE:direct assay:GO:0030133 transport vesicle [PMID:21193403]" /experiment="EXISTENCE:direct assay:GO:0030427 site of polarized growth [PMID:21193403]" /experiment="EXISTENCE:mutant phenotype:GO:0006078 (1->6)-beta-D-glucan biosynthetic process [PMID:7929594]" /experiment="EXISTENCE:mutant phenotype:GO:0015926 glucosidase activity [PMID:10601196]" /experiment="EXISTENCE:mutant phenotype:GO:0031505 fungal-type cell wall organization [PMID:7929594]" /note="Glucosyl hydrolase required for beta-1,6-glucan biosynthesis; type II integral membrane protein that localizes to ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p; KRE6 has a paralog, SKN1, that arose from the whole genome duplication" /db_xref="GeneID:856287" /db_xref="SGD:S000006363" ORIGIN 1 mplrnlteth nfsstnldtd gtgddhdgap lssspsfgqq ndnstndnag ltnpfmgsde 61 esnardgesl sssvhyqpqg sdssllhdns rldlsqnkgv sdykgyysrn nsravstand 121 nsflqpphra iasspslnsn lskndilspp efdryplvgs rvtsmtqlnh hgrsptsspg 181 nessasfssn pflgeqdfsp fggypassfp lmidekeedd ylhnpdpeee arldrrrfid 241 dfkymdkrsa sglagvlllf laaififivl paltftgaid hesnteevty ltqyqypqls 301 airtslvdpd tpdtaktrea mdgskwelvf sdefnaegrt fydgddpywt apdvhydatk 361 dlewyspdas ttvngtlqlr mdafknhgly yrsgmlqswn kvcftqgale isanlpnygr 421 vsglwpglwt mgnlgrpgyl astqgvwpys yescdagitp nqsspdgisy lpgqklsict 481 cdgedhpnqg vgrgapeidv legetdtkig vgiasqslqi apfdiwympd ydfievynft 541 tttmntyagg pfqqavsavs tlnvtwyefg eyggyfqkya ieylndddng yirwfvgdtp 601 tytihakalh pdgnigwrri skepmsiiln lgisnnwayi dwqyiffpvv msidyvriyq 661 psnaisvtcd psdyptydyi qshlnafqna nlttwedagy tfpkniltgk ctsskfklss // LOCUS NP_878184 33 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR159C-A [Saccharomyces cerevisiae S288C]. ACCESSION NP_878184 VERSION NP_878184.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184628.1 REFERENCE 1 (residues 1 to 33) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 33) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 33) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 33) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 33) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 33) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 33) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11576. Method: conceptual translation. FEATURES Location/Qualifiers source 1..33 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..33 /product="uncharacterized protein" /calculated_mol_wt="3453" CDS 1..33 /locus_tag="YPR159C-A" /coded_by="NM_001184628.1:1..102" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /note="hypothetical protein; SWAT-GFP and mCherry fusion proteins localize to the cytosol; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching" /db_xref="GeneID:1466523" /db_xref="SGD:S000028725" ORIGIN 1 matldfttkp lalviymsvv lllmvgvpll fss // LOCUS NP_015486 902 aa linear PLN 30-JUN-2025 DEFINITION glycogen phosphorylase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015486 VERSION NP_015486.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184257.1 REFERENCE 1 (residues 1 to 902) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 902) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 902) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 902) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 902) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 902) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 902) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11577. Method: conceptual translation. FEATURES Location/Qualifiers source 1..902 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..902 /product="glycogen phosphorylase" /EC_number="2.4.1.1" /calculated_mol_wt="103145" Region 68..898 /region_name="GT35_Glycogen_Phosphorylase" /note="glycogen phosphorylase and similar proteins; cd04300" /db_xref="CDD:340853" Site order(68,70,72..73,75..77,100..102,246,341,344) /site_type="other" /note="homodimer interface [polypeptide binding]" /db_xref="CDD:340853" Site order(128,130,187..189,339,342,344,351,390,392,428..429, 433,537,544,630..631,633..636,679,684,686,720..721,743, 745..748,751) /site_type="active" /note="active site pocket [active]" /db_xref="CDD:340853" CDS 1..902 /gene="GPH1" /locus_tag="YPR160W" /coded_by="NM_001184257.1:1..2709" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:14562095|PMID:24146988]" /experiment="EXISTENCE:direct assay:GO:0008184 glycogen phosphorylase activity [PMID:1613787]" /experiment="EXISTENCE:mutant phenotype:GO:0005980 glycogen catabolic process [PMID:2657401]" /experiment="EXISTENCE:mutant phenotype:GO:0008184 glycogen phosphorylase activity [PMID:2657401]" /note="Glycogen phosphorylase required for the mobilization of glycogen; non-essential; regulated by cyclic AMP-mediated phosphorylation; phosphorylation by Cdc28p may coordinately regulate carbohydrate metabolism and the cell cycle; expression is regulated by stress-response elements and by the HOG MAP kinase pathway" /db_xref="GeneID:856289" /db_xref="SGD:S000006364" ORIGIN 1 mppaststtn dmiteeptsp hqiprltrrl tgflpqeiks idtmiplksr alwnkhqvkk 61 fnkaedfqdr fidhvettla rslyncddma ayeaasmsir dnlvidwnkt qqkfttrdpk 121 rvyylslefl mgraldnali nmkiedpedp aaskgkprem ikgalddlgf kledvldqep 181 daglgngglg rlaacfvdsm ategipawgy glryeygifa qkiidgyqve tpdywlnsgn 241 pweiernevq ipvtfygyvd rpeggkttls asqwiggerv lavaydfpvp gfktsnvnnl 301 rlwqarptte fdfakfnngd yknsvaqqqr aesitavlyp ndnfaqgkel rlkqqyfwca 361 aslhdilrrf kkskrpwtef pdqvaiqlnd thptlaivel qrvlvdlekl dwheawdivt 421 ktfaytnhtv mqealekwpv glfghllprh leiiydinwf flqdvakkfp kdvdllsris 481 iieensperq irmaflaivg shkvngvael hselikttif kdfvkfygps kfvnvtngit 541 prrwlkqanp slaklisetl ndpteeylld makltqlgky vedkeflkkw nqvklnnkir 601 lvdlikkend gvdiinreyl ddtlfdmqvk riheykrqql nvfgiiyryl amknmlknga 661 sieevakkyp rkvsifggks apgyymakli iklincvadi vnndesiehl lkvvfvadyn 721 vskaeiiipa sdlsehista gteasgtsnm kfvmngglii gtvdganvei treigednvf 781 lfgnlsenve elrynhqyhp qdlpssldsv lsyiesgqfs penpnefkpl vdsikyhgdy 841 ylvsddfesy lathelvdqe fhnqrsewlk ksvlsvanvg ffssdrciee ysdtiwnvep 901 vt // LOCUS NP_015487 657 aa linear PLN 30-JUN-2025 DEFINITION cyclin-dependent serine/threonine protein kinase SGV1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015487 VERSION NP_015487.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184258.1 REFERENCE 1 (residues 1 to 657) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 657) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 657) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 657) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 657) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11578. Method: conceptual translation. FEATURES Location/Qualifiers source 1..657 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..657 /product="cyclin-dependent serine/threonine protein kinase SGV1" /EC_number="2.7.11.22" /EC_number="2.7.11.23" /calculated_mol_wt="74108" Region 50..366 /region_name="STKc_BUR1" /note="Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), Bypass UAS Requirement 1, and similar proteins; cd07866" /db_xref="CDD:270849" Site order(66..69,74,87,89,106,120,149..152,155,157..158,195, 197,199..200,202,213,216,240,242..245,247,285..286) /site_type="active" /db_xref="CDD:270849" Site order(66..69,74,87,89,120,149..152,155,158,199..200,202, 213) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:270849" Site order(98..100,102,105,109,112,122..125,127,145) /site_type="other" /note="CDK/cyclin interface [polypeptide binding]" /db_xref="CDD:270849" Site order(106,157,195,197,216,240,242..245,247,285..286) /site_type="other" /note="polypeptide substrate binding site [polypeptide binding]" /db_xref="CDD:270849" Site order(212..228,235..247) /site_type="other" /note="activation loop (A-loop)" /db_xref="CDD:270849" CDS 1..657 /gene="SGV1" /locus_tag="YPR161C" /gene_synonym="BUR1" /coded_by="NM_001184258.1:1..1974" /experiment="EXISTENCE:direct assay:GO:0004693 cyclin-dependent protein serine/threonine kinase activity [PMID:10982824]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14749387]" /experiment="EXISTENCE:direct assay:GO:0006368 transcription elongation by RNA polymerase II [PMID:10982824]" /experiment="EXISTENCE:direct assay:GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity [PMID:11390638]" /experiment="EXISTENCE:genetic interaction:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12972617]" /experiment="EXISTENCE:mutant phenotype:GO:0006368 transcription elongation by RNA polymerase II [PMID:10982824]" /experiment="EXISTENCE:mutant phenotype:GO:0032968 positive regulation of transcription elongation by RNA polymerase II [PMID:12972617]" /experiment="EXISTENCE:physical interaction:GO:0000307 cyclin-dependent protein kinase holoenzyme complex [PMID:10982824]" /note="Cyclin (Bur2p)-dependent protein kinase; subunit of the CDK-cyclin BUR kinase complex with Bur2p; regulates Set2p-dependent H3K36 trimethylation; regulates transcriptional elongation through the phosphorylation of the carboxy-terminal domain (CTD) of Rpo21p; stimulates recruitment of the PAF complex through Spt5p CTD phosphorylation; recruits Spt6p to the CTD at the onset of transcription; regulates telomere elongation; regulated by Cak1p; similar to metazoan CDK9 proteins" /db_xref="GeneID:856290" /db_xref="SGD:S000006365" ORIGIN 1 msdngspavl pktefnkyki gkvkstpaiq rdaktnltyi klrkrssekv ygctvfqnhy 61 redeklgqgt fgevykgihl etqrqvamkk iivsvekdlf pitaqreiti lkrlnhknii 121 kliemvydhs pditnaassn lhksfymilp ymvadlsgvl hnprinlemc diknmmlqil 181 eglnyihcak fmhrdiktan ilidhngvlk ladfglarly ygcppnlkyp ggagsgakyt 241 svvvtrwyra pelvlgdkqy ttavdiwgvg cvfaeffekk pilqgktdid qghvifkllg 301 tpteedwava rylpgaeltt tnykptlrer fgkylsetgl dflgqllald pykrltamsa 361 khhpwfkedp lpsekitlpt eesheadikr ykeemhqsls qrvptaprgh ivekgespvv 421 knlgaiprgp kkddasflpp sknvlakppp skirelhqnp rpyhvnsgya ktaipppaap 481 agvnrygpnn ssrnnrfsgn stapnnsrnp vnrfhpetnv sskynkvplp lgpqsryqgn 541 snesryknsp ndsryhnpry vnkpetnfnr qpqkysrqes napinknynp sngsrnmagd 601 hhqgsrpshp qfpispsqgq hqltskpiek kngsfkdera kpdeskefqn sdiadly // LOCUS NP_015488 529 aa linear PLN 30-JUN-2025 DEFINITION origin recognition complex subunit 4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015488 VERSION NP_015488.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184259.1 REFERENCE 1 (residues 1 to 529) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 529) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 529) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 529) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 529) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11579. Method: conceptual translation. FEATURES Location/Qualifiers source 1..529 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..529 /product="origin recognition complex subunit 4" /calculated_mol_wt="60575" Region 81..>276 /region_name="CDC6" /note="Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]; COG1474" /db_xref="CDD:441083" Region 286..517 /region_name="ORC4_C" /note="Origin recognition complex (ORC) subunit 4 C-terminus; pfam14629" /db_xref="CDD:464223" CDS 1..529 /gene="ORC4" /locus_tag="YPR162C" /coded_by="NM_001184259.1:1..1590" /experiment="EXISTENCE:direct assay:GO:0003688 DNA replication origin binding [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0005656 nuclear pre-replicative complex [PMID:16824194|PMID:9335335]" /experiment="EXISTENCE:direct assay:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:direct assay:GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication [PMID:16824194]" /experiment="EXISTENCE:direct assay:GO:0030466 silent mating-type cassette heterochromatin formation [PMID:12897051]" /experiment="EXISTENCE:direct assay:GO:0031261 DNA replication preinitiation complex [PMID:9554851]" /experiment="EXISTENCE:mutant phenotype:GO:0005664 nuclear origin of replication recognition complex [PMID:9372948]" /experiment="EXISTENCE:mutant phenotype:GO:0006270 DNA replication initiation [PMID:16716188]" /note="Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that arose from the whole genome duplication" /db_xref="GeneID:856291" /db_xref="SGD:S000006366" ORIGIN 1 mtisearlsp qvnllpikrh sneeveetaa ilkkrtidne kckdsdpgfg slqrrllqql 61 ygtlptdeki iftylqdcqq eidriikqsi iqkeshsvil vgprqsykty lldyelsllq 121 qsykeqfiti rlngfihseq taingiatql eqqlqkihgs eekiddtsle tissgsltev 181 fekillllds ttktrnedsg evdresitki tvvfifdeid tfagpvrqtl lynlfdmveh 241 srvpvcifgc ttklnileyl ekrvksrfsq rviympqiqn lddmvdavrn lltvrseisp 301 wvsqwnetle kelsdprsnl nrhirmnfet frslptlkns iiplvatskn fgslctaiks 361 csfldiynkn qlsnnltgrl qslsdlelai lisaarvalr akdgsfnfnl ayaeyekmik 421 ainsriptva pttnvgtgqs tfsidntikl wlkkdvknvw enlvqldfft eksavglrdn 481 ataafyasny qfqgtmipfd lrsyqmqiil qelrriipks nmyyswtql // LOCUS NP_015489 436 aa linear PLN 30-JUN-2025 DEFINITION Tif3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015489 VERSION NP_015489.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184260.1 REFERENCE 1 (residues 1 to 436) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 436) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 436) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 436) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 436) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11580. Method: conceptual translation. FEATURES Location/Qualifiers source 1..436 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..436 /product="Tif3p" /calculated_mol_wt="48391" Region 102..179 /region_name="RRM4_RBM12_like" /note="RNA recognition motif 4 (RRM4) found in RNA-binding protein RBM12, RBM12B and similar proteins; cd12514" /db_xref="CDD:409936" CDS 1..436 /gene="TIF3" /locus_tag="YPR163C" /gene_synonym="RBL3; STM1" /coded_by="NM_001184260.1:1..1311" /experiment="EXISTENCE:direct assay:GO:0003723 RNA binding [PMID:7543843]" /experiment="EXISTENCE:direct assay:GO:0003727 single-stranded RNA binding [PMID:23236192]" /experiment="EXISTENCE:direct assay:GO:0003729 mRNA binding [PMID:23222640]" /experiment="EXISTENCE:direct assay:GO:0006413 translational initiation [PMID:7543843]" /experiment="EXISTENCE:direct assay:GO:0010494 cytoplasmic stress granule [PMID:26777405]" /experiment="EXISTENCE:direct assay:GO:0033592 RNA strand annealing activity [PMID:7543843]" /experiment="EXISTENCE:direct assay:GO:0034057 RNA strand-exchange activity [PMID:9769100]" /experiment="EXISTENCE:direct assay:GO:0043024 ribosomal small subunit binding [PMID:23236192]" /experiment="EXISTENCE:genetic interaction:GO:0006413 translational initiation [PMID:8404866]" /experiment="EXISTENCE:genetic interaction:GO:0097010 eukaryotic translation initiation factor 4F complex assembly [PMID:23184954]" /experiment="EXISTENCE:mutant phenotype:GO:0001731 formation of translation preinitiation complex [PMID:23236192]" /experiment="EXISTENCE:mutant phenotype:GO:0002181 cytoplasmic translation [PMID:8404865]" /experiment="EXISTENCE:mutant phenotype:GO:0006413 translational initiation [PMID:8404866]" /experiment="EXISTENCE:mutant phenotype:GO:0097010 eukaryotic translation initiation factor 4F complex assembly [PMID:23184954]" /note="Translation initiation factor eIF-4B; RNA recognition motif containing single-stranded RNA binding protein that possesses RNA annealing and strand-exchange activities; stimulates the ATPase and unwinding activities of the RNA helicase eIF4A, in a synergistic manner with eIF4G; promotes assembly of the translation initiation factor complex eIF4F and the 48S preinitiation complex; interacts with Rps20p at the head of the 40S ribosomal subunit and alters the structure of the mRNA entry channel" /db_xref="GeneID:856292" /db_xref="SGD:S000006367" ORIGIN 1 mappkktvkk mdltsflndd tfgsswaeed vdlnkitipi etanantipl selahaknns 61 nntrsggfgg sfggrsrldp algggssdrr eeypvpdapp yravinnipw ditpegvqaw 121 vedglvkpea veevvlpknl rdptrlkgna fvtlkeradl vavlkfngtk lnertvyvsv 181 aaprrgggad vdwssargsn fqgdgredap dldwgaargs nfrgprrere evdidwtaar 241 gsnfqgssrp prrereevdi dwsaargsnf qgssrpprre reepdidwsa argsnfqsss 301 rpprrereep didwsaargs nfqsssrppr rerekeepal dwgaargaqf gkpqqtknty 361 kdrsltnkkt tdeqpkiqks vydvlrtedd dedeeaekqn gdakenkvda aveklqdkta 421 qltvedgdnw evvgkk // LOCUS NP_015490 1407 aa linear PLN 30-JUN-2025 DEFINITION Mms1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015490 VERSION NP_015490.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184261.1 REFERENCE 1 (residues 1 to 1407) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1407) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1407) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1407) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1407) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11581. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1407 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1407 /product="Mms1p" /calculated_mol_wt="161108" CDS 1..1407 /gene="MMS1" /locus_tag="YPR164W" /gene_synonym="RTT108; SLM6" /coded_by="NM_001184261.1:1..4224" /experiment="EXISTENCE:direct assay:GO:0035361 Cul8-RING ubiquitin ligase complex [PMID:20139071]" /experiment="EXISTENCE:mutant phenotype:GO:0000725 recombinational repair [PMID:18321796]" /experiment="EXISTENCE:mutant phenotype:GO:0010526 transposable element silencing [PMID:11779788]" /experiment="EXISTENCE:mutant phenotype:GO:0031297 replication fork processing [PMID:18704118]" /experiment="EXISTENCE:mutant phenotype:GO:0070651 nonfunctional rRNA decay [PMID:19390089]" /note="Subunit of E3 ubiquitin ligase complex involved in replication repair; stabilizes protein components of the replication fork such as the fork-pausing complex and leading strand polymerase, preventing fork collapse and promoting efficient recovery during replication stress; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay" /db_xref="GeneID:856293" /db_xref="SGD:S000006368" ORIGIN 1 mlglrthgld ryehyirrps dfgklelqdw lnhksfrvsp nllidssttr ewnepelfyq 61 ntedetwvrp cvgpklepsm mmlryhdsni gqmpqfcypi sspinfkpvl kyilqersel 121 sdgfpqkynt ligslfdidk npetlddsdi ealddiemss dsgnvkepki elqaleeiqq 181 khfslivsnn gifqtgstsi tyiqsgisgs iaikpnnvai lilltqpsgh llsilplddg 241 ketyllqywn lgqkgqwnii khqnekqfvl ihkelgickf fefhlpftfq lvnnltltds 301 vimngsffpt nytdldpyfi ifitairyer ivyfviewnn neikkkevyq ltvfdgektn 361 mtipiglnac lvetplkfsl vsanqimsge tefhsfqlka lkgiksffpa pllllklqel 421 hphtfkkfqy ctiissstgn icfcvterst ivngnlkfye ltrfkglksi splpsnpinl 481 dsrsssyvlv visfsrtlel tlsledlrcl dkkdvikplk nitfkhtids steensqila 541 ftsskfynth tgsnindtrn sqvwltspna itqpcidykl rkthqlihlk qfqifrhlri 601 wkcknldial lqrlginqsn tesslifatd avsnnrifll dltmtttidn ddpvqglini 661 edllcdtene tillnftknn liqvtrdtiy idpiggdkel rkispgwefe nvtyndgili 721 vwnaglgcvs yienidavde sgalvsnlss skgmskffkq lgtvtsvnfq ikestddptk 781 ydiwillpdc virtpfsdwi sdsldfsdvy ilsvqqalin gpyfcsldye syfevhtlqn 841 ncfkkgsrct srvnfqgkdi kfrsfgvnqc lafsafeifv inltpihdsr eldfyklklp 901 hlgnnnsile vcpdiennql filysdglri lelsyltsnn gnfllkstrs knkkflyldk 961 inrmlvlnqd lrewecirls dgkavgldsq llkddseeil eikelpiate dnplekktvl 1021 lisftsslkl vlltaaknki snqiidsykl dnsrllnhlv itprgeiffl dykvmgtdne 1081 msfnklkvtk hcidqeernn ttlrltletr ftfkswstvk tftvvgdnii attnmgekly 1141 likdfssssd esrrvyplem ypdskvqkii plneccfvva aycgnrndld srlifyslpt 1201 ikvglnnetg slpdeygngr vddifevdfp egfqfgtmal ydvlhgerhv nrysegirse 1261 ndeaevalrq rrnlllfwrn hsstpkpslr raativyedh vssryfedis silgstamrt 1321 krlspynava ldkpiqdisy dpavqtlyvl madqtihkfg kdrlpcqdey eprwnsgylv 1381 srrsivksdl icevglwnls dnckntv // LOCUS NP_015491 209 aa linear PLN 30-JUN-2025 DEFINITION Rho family GTPase RHO1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015491 VERSION NP_015491.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184262.1 REFERENCE 1 (residues 1 to 209) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 209) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 209) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 209) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 209) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11582. Method: conceptual translation. FEATURES Location/Qualifiers source 1..209 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..209 /product="Rho family GTPase RHO1" /EC_number="3.6.5.2" /calculated_mol_wt="23021" Region 10..184 /region_name="RhoA_like" /note="Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC; cd01870" /db_xref="CDD:206662" Site order(10,39,42..43,46,48,50,59,63..64,66..68,71,73,77) /site_type="other" /note="GEF (guanine nucleotide exchange factor) interaction site [polypeptide binding]" /db_xref="CDD:206662" Site 17..24 /site_type="other" /note="G1 box" /db_xref="CDD:206662" Site order(20..25,39..40,42,64..65,123,125,166..167) /site_type="other" /note="GTP/Mg2+ binding site [chemical binding]" /db_xref="CDD:206662" Site order(28,30..34,47..48,50..52,57..59,168..169,173..174,177) /site_type="active" /note="PKN/PRK1 effector interaction site [active]" /db_xref="CDD:206662" Site order(39,41,43..44,68..71,74,77,99) /site_type="other" /note="GAP (GTPase-activating protein) interaction site [polypeptide binding]" /db_xref="CDD:206662" Site 39..47 /site_type="other" /note="Switch I region" /db_xref="CDD:206662" Site order(42..43,66,71,73..74,76..77,80,110..111,113) /site_type="other" /note="GDI (guanine nucleotide dissociation inhibitor) interaction site [polypeptide binding]" /db_xref="CDD:206662" Site 42 /site_type="other" /note="G2 box" /db_xref="CDD:206662" Site order(44,70..74,77,102,106,110) /site_type="active" /note="Mdia effector interaction site [active]" /db_xref="CDD:206662" Site order(44..45,70..71,73..74,77) /site_type="other" /note="Rho kinase (ROCK) effector interaction site [polypeptide binding]" /db_xref="CDD:206662" Site 64..67 /site_type="other" /note="G3 box" /db_xref="CDD:206662" Site 67..84 /site_type="other" /note="Switch II region" /db_xref="CDD:206662" Site 122..125 /site_type="other" /note="G4 box" /db_xref="CDD:206662" Site 165..167 /site_type="other" /note="G5 box" /db_xref="CDD:206662" CDS 1..209 /gene="RHO1" /locus_tag="YPR165W" /coded_by="NM_001184262.1:1..630" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:8195291]" /experiment="EXISTENCE:direct assay:GO:0000148 1,3-beta-D-glucan synthase complex [PMID:8602515]" /experiment="EXISTENCE:direct assay:GO:0000329 fungal-type vacuole membrane [PMID:11598008]" /experiment="EXISTENCE:direct assay:GO:0003924 GTPase activity [PMID:7962098|PMID:11591390]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:24769239|PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:15596542]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005794 Golgi apparatus [PMID:1918143]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:16622836]" /experiment="EXISTENCE:direct assay:GO:0005933 cellular bud [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:8195291]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:8195291]" /experiment="EXISTENCE:direct assay:GO:0007264 small GTPase-mediated signal transduction [PMID:8621575]" /experiment="EXISTENCE:direct assay:GO:0008047 enzyme activator activity [PMID:37703377|PMID:36949198]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:12660244]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0090334 regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [PMID:36949198|PMID:8662910|PMID:8602515]" /experiment="EXISTENCE:genetic interaction:GO:0007117 budding cell bud growth [PMID:8195291]" /experiment="EXISTENCE:genetic interaction:GO:0007264 small GTPase-mediated signal transduction [PMID:8846785]" /experiment="EXISTENCE:genetic interaction:GO:0030036 actin cytoskeleton organization [PMID:8947028]" /experiment="EXISTENCE:genetic interaction:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:12419188]" /experiment="EXISTENCE:mutant phenotype:GO:0007117 budding cell bud growth [PMID:8195291]" /experiment="EXISTENCE:mutant phenotype:GO:0008361 regulation of cell size [PMID:17302939]" /experiment="EXISTENCE:mutant phenotype:GO:0030036 actin cytoskeleton organization [PMID:15596542]" /experiment="EXISTENCE:mutant phenotype:GO:0032186 cellular bud neck septin ring organization [PMID:26179915]" /experiment="EXISTENCE:mutant phenotype:GO:0032880 regulation of protein localization [PMID:10893184]" /experiment="EXISTENCE:mutant phenotype:GO:0032889 regulation of vacuole fusion, non-autophagic [PMID:11598008]" /experiment="EXISTENCE:mutant phenotype:GO:0045807 positive regulation of endocytosis [PMID:14593073]" /experiment="EXISTENCE:mutant phenotype:GO:0060178 regulation of exocyst localization [PMID:11283608]" /experiment="EXISTENCE:mutant phenotype:GO:0060237 regulation of fungal-type cell wall organization [PMID:8621575]" /experiment="EXISTENCE:mutant phenotype:GO:0090334 regulation of cell wall (1->3)-beta-D-glucan biosynthetic process [PMID:8662910|PMID:8602514|PMID:8602515]" /experiment="EXISTENCE:mutant phenotype:GO:1903395 regulation of secondary cell septum biogenesis [PMID:23878277]" /experiment="EXISTENCE:mutant phenotype:GO:1903501 positive regulation of mitotic actomyosin contractile ring assembly [PMID:12419188]" /experiment="EXISTENCE:physical interaction:GO:0030036 actin cytoskeleton organization [PMID:8947028]" /experiment="EXISTENCE:physical interaction:GO:0031681 G-protein beta-subunit binding [PMID:12660244]" /note="GTP-binding protein of the rho subfamily of Ras-like small GTPases; involved in establishment of cell polarity; regulates protein kinase C (Pkc1p); positive regulatory subunit of the 1,3-beta-D-glucan synthase complex, activating 1,3-beta-glucan synthase (Fks1p and Gsc2p), an enzyme involved in cell wall biosynthesis" /db_xref="GeneID:856294" /db_xref="SGD:S000006369" ORIGIN 1 msqqvgnsir rklvivgdga cgktcllivf skgqfpevyv ptvfenyvad vevdgrrvel 61 alwdtagqed ydrlrplsyp dsnvvlicfs idlpdslenv qekwiaevlh fcqgvpiilv 121 gckvdlrndp qtieqlrqeg qqpvtsqegq svadqigatg yyecsaktgy gvrevfeaat 181 raslmgkskt ngkakkntte kkkkkcvll // LOCUS NP_015492 115 aa linear PLN 30-JUN-2025 DEFINITION mitochondrial 37S ribosomal protein uS14m MRP2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015492 VERSION NP_015492.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184263.1 REFERENCE 1 (residues 1 to 115) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 115) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 115) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 115) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 115) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11583. Method: conceptual translation. FEATURES Location/Qualifiers source 1..115 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..115 /product="mitochondrial 37S ribosomal protein uS14m MRP2" /calculated_mol_wt="13407" Region 61..112 /region_name="Ribosomal_S14" /note="Ribosomal protein S14p/S29e; pfam00253" /db_xref="CDD:459734" CDS 1..115 /gene="MRP2" /locus_tag="YPR166C" /gene_synonym="uS14m" /coded_by="NM_001184263.1:1..348" /experiment="EXISTENCE:curator inference:GO:0032543 mitochondrial translation [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0003735 structural constituent of ribosome [PMID:11278769]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:16823961|PMID:24769239]" /experiment="EXISTENCE:direct assay:GO:0005763 mitochondrial small ribosomal subunit [PMID:11278769]" /note="Mitochondrial ribosomal protein of the small subunit" /db_xref="GeneID:856295" /db_xref="SGD:S000006370" ORIGIN 1 mgnfrfpikt klppgfinar ilrdnfkrqq fkeneilvks lkfiarnmnl ptklrleaql 61 klnalpnymr stqiknrcvd sgharfvlsd frlcryqfre nalkgnlpgv kkgiw // LOCUS NP_015493 261 aa linear PLN 30-JUN-2025 DEFINITION phosphoadenylyl-sulfate reductase (thioredoxin) [Saccharomyces cerevisiae S288C]. ACCESSION NP_015493 VERSION NP_015493.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184264.1 REFERENCE 1 (residues 1 to 261) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 261) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 261) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 261) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 261) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11584. Method: conceptual translation. FEATURES Location/Qualifiers source 1..261 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..261 /product="phosphoadenylyl-sulfate reductase (thioredoxin)" /EC_number="1.8.4.8" /calculated_mol_wt="30249" Region 17..248 /region_name="PAPS_reductase" /note="phosphoadenosine phosphosulfate reductase, thioredoxin dependent; TIGR02057" /db_xref="CDD:131112" CDS 1..261 /gene="MET16" /locus_tag="YPR167C" /coded_by="NM_001184264.1:1..786" /experiment="EXISTENCE:curator inference:GO:0005737 cytoplasm [PMID:3060034]" /experiment="EXISTENCE:direct assay:GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity [PMID:3060034]" /experiment="EXISTENCE:direct assay:GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [PMID:3060034]" /experiment="EXISTENCE:mutant phenotype:GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity [PMID:2203779]" /experiment="EXISTENCE:mutant phenotype:GO:0019379 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) [PMID:197388]" /note="3'-phosphoadenylsulfate reductase; reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism" /db_xref="GeneID:856296" /db_xref="SGD:S000006371" ORIGIN 1 mktyhlnndi ivtqeqldhw neqlikletp qeiiawsivt fphlfqttaf gltglvtidm 61 lsklsekyym pellfidtlh hfpqtltlkn eiekkyyqpk nqtihvykpd gceseadfas 121 kygdflwekd ddkydylakv epahraykel hisavftgrr ksqgsarsql siieidelng 181 ilkinplinw tfeqvkqyid annvpynell dlgyrsigdy hstqpvkege deragrwkgk 241 aktecgihea srfaqflkqd a // LOCUS NP_015494 157 aa linear PLN 30-JUN-2025 DEFINITION mediator complex subunit NUT2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015494 VERSION NP_015494.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184265.1 REFERENCE 1 (residues 1 to 157) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 157) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 157) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 157) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 157) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11585. Method: conceptual translation. FEATURES Location/Qualifiers source 1..157 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..157 /product="mediator complex subunit NUT2" /calculated_mol_wt="17777" Region 19..142 /region_name="Med10" /note="Transcription factor subunit Med10 of Mediator complex; pfam09748" /db_xref="CDD:462879" CDS 1..157 /gene="NUT2" /locus_tag="YPR168W" /gene_synonym="MED10" /coded_by="NM_001184265.1:1..474" /experiment="EXISTENCE:direct assay:GO:0070847 core mediator complex [PMID:9891034]" /experiment="EXISTENCE:genetic interaction:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:9671481]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:16452140]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:9891034]" /experiment="EXISTENCE:mutant phenotype:GO:0051123 RNA polymerase II preinitiation complex assembly [PMID:27688401]" /note="Subunit of the RNA polymerase II mediator complex; conserved from yeast to human; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856297" /db_xref="SGD:S000006372" ORIGIN 1 mngnstnneq lqqelattqd qvasiiesfv elgvsiydfp gtpeatkgmi tnlqrnvdrl 61 yklnvrsndp qsslskvdip levvqyiedg rnpdiytref veairrsnqy qrgkmhglkq 121 lrdsladkiv defpelkepv ediikrtspi dnvsnth // LOCUS NP_015495 492 aa linear PLN 30-JUN-2025 DEFINITION Jip5p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015495 VERSION NP_015495.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184266.1 REFERENCE 1 (residues 1 to 492) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 492) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 492) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 492) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 492) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11586. On Dec 12, 2005 this sequence version replaced NP_015495.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..492 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..492 /product="Jip5p" /calculated_mol_wt="55133" Region 132..168 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 184..219 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 227..273 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 281..322 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 329..352 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..492 /gene="JIP5" /locus_tag="YPR169W" /coded_by="NM_001184266.1:1..1479" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:14690591]" /experiment="EXISTENCE:direct assay:GO:0005730 nucleolus [PMID:14562095|PMID:14690591]" /experiment="EXISTENCE:mutant phenotype:GO:0042273 ribosomal large subunit biogenesis [PMID:19806183]" /note="Protein required for biogenesis of the large ribosomal subunit; required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein; essential gene" /db_xref="GeneID:856298" /db_xref="SGD:S000006373" ORIGIN 1 makskkktdv vdstnlpile llslkapifq sllhpelpii itgfgtghiv chrydpaklq 61 shldrrrrid tattgkdakk gvcpwirldi dletgdlkfv dieeqqqqkq tgkdedlgvk 121 tlwktkrhkg svramcfdsk gdnifsvgsd nvlkkantmt gkvvkkvnls slfnseekkn 181 dkftklcasq thpfiligde sgnihvinse nlalsnsirs ihfgdsindi fhfdkrsayk 241 fislgqttla yfdvrdkdak pnvagnedgk ilisddqede vlcgcfvdpe vadtllcgmg 301 egivtvwkpn kndledqmsr ikiskdesid civptlqddn cvwcgcsngn iykvnaklgk 361 vveirnhsel devsfvdldf eyrvvsggle nikiwelssd dveenasves dsdeplshsd 421 edlsddtssd dettlvglsk eelldeldkd lkedhqeeke snsksvkkrk imkennkkkd 481 lyehgikkfd dl // LOCUS NP_001106949 85 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR170W-B [Saccharomyces cerevisiae S288C]. ACCESSION NP_001106949 VERSION NP_001106949.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184525.1 REFERENCE 1 (residues 1 to 85) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 85) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 85) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 85) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 85) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11587. Method: conceptual translation. FEATURES Location/Qualifiers source 1..85 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..85 /product="uncharacterized protein" /calculated_mol_wt="9230" CDS 1..85 /locus_tag="YPR170W-B" /coded_by="NM_001184525.1:1..258" /note="Putative, non-essential component vacuolar ATPase; conserved in fungi; SWAT-GFP fusion protein localizes to vacuole membrane; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C" /db_xref="GeneID:5848745" /db_xref="SGD:S000028515" ORIGIN 1 mrpvvstgka wcctvlsafg vvilsviahl fntnhesfvg sindpedgpa vahtvylaal 61 vylvffvfcg fqvylarrkp sielr // LOCUS NP_015497 576 aa linear PLN 30-JUN-2025 DEFINITION Bsp1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015497 VERSION NP_015497.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184268.1 REFERENCE 1 (residues 1 to 576) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 576) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 576) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 576) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 576) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11588. Method: conceptual translation. FEATURES Location/Qualifiers source 1..576 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..576 /product="Bsp1p" /calculated_mol_wt="64535" CDS 1..576 /gene="BSP1" /locus_tag="YPR171W" /coded_by="NM_001184268.1:1..1731" /experiment="EXISTENCE:direct assay:GO:0005934 cellular bud tip [PMID:12606027]" /experiment="EXISTENCE:direct assay:GO:0005935 cellular bud neck [PMID:12606027]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:12606027]" /experiment="EXISTENCE:direct assay:GO:0030479 actin cortical patch [PMID:38088874|PMID:12606027]" /experiment="EXISTENCE:direct assay:GO:0030674 protein-macromolecule adaptor activity [PMID:12606027]" /experiment="EXISTENCE:direct assay:GO:0043332 mating projection tip [PMID:19053807]" /experiment="EXISTENCE:direct assay:GO:0051015 actin filament binding [PMID:38088874]" /experiment="EXISTENCE:direct assay:GO:0110085 mitotic actomyosin contractile ring [PMID:38088874]" /experiment="EXISTENCE:mutant phenotype:GO:0044379 protein localization to actin cortical patch [PMID:38088874]" /experiment="EXISTENCE:mutant phenotype:GO:0051015 actin filament binding [PMID:38088874]" /experiment="EXISTENCE:mutant phenotype:GO:0051666 actin cortical patch localization [PMID:12606027]" /experiment="EXISTENCE:mutant phenotype:GO:1904498 protein localization to mitotic actomyosin contractile ring [PMID:38088874]" /note="Actin filament binding protein; regulates actin filament capping by recruiting capping protein to endocytic sites and to the cytokinetic actin ring; interacts with the capping protein complex; adapter that links synaptojanins, Inp52p and Inp53p, to the cortical actin cytoskeleton; contains two WH2-like actin binding domains and a C-terminal capping protein interaction (CPI) motif" /db_xref="GeneID:856301" /db_xref="SGD:S000006375" ORIGIN 1 mtkyerdpel vnflskvedl nskrysnips skpagealsp vrshnsgeyr radmmtgknv 61 egcdnlayrs aynyemtfsp kkthyslsel nleritprpd legsasqkek kfliseedyl 121 llqklkasqt yndsnadknl psfekgprmp srgrprprek eiitiqydfe lpgradipss 181 sssssppplp trrdhikitd gneekpllpt rpnkaevtes pssrsikpda vvpervkpap 241 pvsrstkpas flsslednkl tkaksynsem etpkttvkss hidyldsiql kpttlsptmk 301 nkpkptppsp pakriprses fiksmlnsnl tttskpslpe kpqklrnanl aahktkpsip 361 pkkvelnivl pelrpvetsp tkqnfensid lpklrssnrn ikkeeedsip eaikgiqnlk 421 ktkqqkpaip qkksfltnns knttlkngdd inklndeiea lslrnnlkkr pptapqrkis 481 lpealrkvel mkksktepvl essnelsina kldaiiasrn lrasntlpel sgvntniats 541 dkyttsrdet vketkplvhp nknrtrgprr klptrv // LOCUS NP_015498 200 aa linear PLN 30-JUN-2025 DEFINITION pyridoxal 5'-phosphate synthase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015498 VERSION NP_015498.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184269.1 REFERENCE 1 (residues 1 to 200) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 200) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 200) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 200) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 200) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11589. Method: conceptual translation. FEATURES Location/Qualifiers source 1..200 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..200 /product="pyridoxal 5'-phosphate synthase" /calculated_mol_wt="22376" Region 7..>85 /region_name="Putative_PNPOx" /note="Pyridoxamine 5'-phosphate oxidase; pfam01243" /db_xref="CDD:426149" CDS 1..200 /locus_tag="YPR172W" /coded_by="NM_001184269.1:1..603" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276|PMID:14562095]" /note="hypothetical protein; predicted to encode a pyridoxal 5'-phosphate synthase based on sequence similarity but purified protein does not possess this activity, nor does it bind flavin mononucleotide (FMN); transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication" /db_xref="GeneID:856302" /db_xref="SGD:S000006376" ORIGIN 1 mawtstlpah llnliknsky vhvatcskdc ipsvalmnyi yvpgeklfgq tdnkndyiif 61 vspqdtqkfy nikenpkval lfhdwiiann lsvgkesisg tptptsiphe eqrqsellnl 121 lqelnqaeln qmsasigget eivnpesees kyykdlilka npdakafife kntavvkvri 181 dnarvsnnen rtmflskgks // LOCUS NP_015499 437 aa linear PLN 30-JUN-2025 DEFINITION AAA family ATPase VPS4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015499 VERSION NP_015499.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184270.1 REFERENCE 1 (residues 1 to 437) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 437) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 437) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 437) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 437) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11590. Method: conceptual translation. FEATURES Location/Qualifiers source 1..437 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..437 /product="AAA family ATPase VPS4" /calculated_mol_wt="48041" Region 17..432 /region_name="cell_div_CdvC" /note="cell division protein CdvC; NF041006" /db_xref="CDD:468935" Region 127..296 /region_name="RecA-like_VPS4" /note="ATPase domain of vacuolar protein sorting-associated protein 4; cd19521" /db_xref="CDD:410929" Site order(128,147,151,154..155,159,163,175..176,180,184,194, 196,198..200,203,211,232..233,236,241,243,245..247, 249..251,254..255,278,281) /site_type="other" /note="hexamer interface [polypeptide binding]" /db_xref="CDD:410929" Site order(134..136,138,175..181,232,277) /site_type="other" /note="ATP binding site [chemical binding]" /db_xref="CDD:410929" CDS 1..437 /gene="VPS4" /locus_tag="YPR173C" /gene_synonym="CSC1; DID6; END13; GRD13; VPL4; VPT10" /coded_by="NM_001184270.1:1..1314" /experiment="EXISTENCE:direct assay:GO:0005524 ATP binding [PMID:9606181]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0005768 endosome [PMID:9606181]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0016020 membrane [PMID:16601096]" /experiment="EXISTENCE:direct assay:GO:0016887 ATP hydrolysis activity [PMID:16505166|PMID:9155008|PMID:9606181]" /experiment="EXISTENCE:direct assay:GO:0061709 reticulophagy [PMID:31802527]" /experiment="EXISTENCE:genetic interaction:GO:0016125 sterol metabolic process [PMID:16096648]" /experiment="EXISTENCE:mutant phenotype:GO:0005524 ATP binding [PMID:9606181]" /experiment="EXISTENCE:mutant phenotype:GO:0016125 sterol metabolic process [PMID:16096648]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:17428789]" /experiment="EXISTENCE:mutant phenotype:GO:0016887 ATP hydrolysis activity [PMID:9155008]" /experiment="EXISTENCE:mutant phenotype:GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway [PMID:16505166]" /experiment="EXISTENCE:mutant phenotype:GO:0045053 protein retention in Golgi apparatus [PMID:8649377]" /experiment="EXISTENCE:mutant phenotype:GO:0045324 late endosome to vacuole transport [PMID:9211789|PMID:9606181]" /experiment="EXISTENCE:mutant phenotype:GO:0070676 intralumenal vesicle formation [PMID:19234443]" /note="AAA-ATPase involved in multivesicular body (MVB) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism" /db_xref="GeneID:856303" /db_xref="SGD:S000006377" ORIGIN 1 mstgdfltkg ielvqkaidl dtatqyeeay tayyngldyl mlalkyeknp kskdlirakf 61 teylnraeql kkhleseean aakkspsags gsnggnkkis qeegedngge dnkklrgals 121 sailsekpnv kwedvagleg akealkeavi lpvkfphlfk gnrkptsgil lygppgtgks 181 ylakavatea nstffsvsss dlvskwmges eklvkqlfam arenkpsiif idevdaltgt 241 rgegeseasr riktellvqm ngvgndsqgv lvlgatnipw qldsairrrf erriyiplpd 301 laarttmfei nvgdtpcvlt kedyrtlgam tegysgsdia vvvkdalmqp irkiqsathf 361 kdvsteddet rkltpcspgd dgaiemswtd ieadelkepd ltikdflkai kstrptvned 421 dllkqeqftr dfgqegn // LOCUS NP_015500 221 aa linear PLN 30-JUN-2025 DEFINITION Csa1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015500 VERSION NP_015500.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184271.1 REFERENCE 1 (residues 1 to 221) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 221) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 221) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 221) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 221) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11591. Method: conceptual translation. FEATURES Location/Qualifiers source 1..221 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..221 /product="Csa1p" /calculated_mol_wt="25280" Region <94..221 /region_name="NBP1" /note="Fungal Nap binding protein NBP1; pfam08537" /db_xref="CDD:400720" CDS 1..221 /gene="CSA1" /locus_tag="YPR174C" /coded_by="NM_001184271.1:1..666" /experiment="EXISTENCE:direct assay:GO:0005635 nuclear envelope [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005816 spindle pole body [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0034399 nuclear periphery [PMID:22842922]" /experiment="EXISTENCE:direct assay:GO:1902365 positive regulation of protein localization to spindle pole body [PMID:32553169]" /note="hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study; relative distribution to foci at the nuclear periphery increases upon DNA replication stress; YPR174C has a paralog, NBP1, that arose from the whole genome duplication" /db_xref="GeneID:856304" /db_xref="SGD:S000006378" ORIGIN 1 mgiqektlgi rkerklvvvp rernhvrhas qrtrsknykn iskkraqqha fgfniaktla 61 kiqafvwgsp adeeeesvvp lsknsqdcvp lqwqakfaql rqqlhstqke lqfvkekchl 121 lqsvlddani dqrylesrrd mknierdnlk ptenlppspv ravnplvtss pihmsplqsr 181 qrpvsslqpp kgpnfyakyp klpqtnilre sptedsvpha e // LOCUS NP_015501 689 aa linear PLN 30-JUN-2025 DEFINITION DNA polymerase epsilon noncatalytic subunit [Saccharomyces cerevisiae S288C]. ACCESSION NP_015501 VERSION NP_015501.2 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184272.1 REFERENCE 1 (residues 1 to 689) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 689) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 689) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 689) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 689) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11592. On Oct 2, 2003 this sequence version replaced NP_015501.1. Method: conceptual translation. FEATURES Location/Qualifiers source 1..689 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..689 /product="DNA polymerase epsilon noncatalytic subunit" /calculated_mol_wt="78209" Region 400..650 /region_name="DNA_pol_E_B" /note="DNA polymerase alpha/epsilon subunit B; pfam04042" /db_xref="CDD:461142" CDS 1..689 /gene="DPB2" /locus_tag="YPR175W" /coded_by="NM_001184272.1:1..2070" /experiment="EXISTENCE:direct assay:GO:0003690 double-stranded DNA binding [PMID:16916794|PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0003697 single-stranded DNA binding [PMID:14622139]" /experiment="EXISTENCE:direct assay:GO:0003887 DNA-directed DNA polymerase activity [PMID:12882968]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15282802]" /experiment="EXISTENCE:direct assay:GO:0006261 DNA-templated DNA replication [PMID:12882968|PMID:14622139|PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0008622 epsilon DNA polymerase complex [PMID:2406268|PMID:12571237|PMID:14673157]" /experiment="EXISTENCE:direct assay:GO:0030337 DNA polymerase processivity factor activity [PMID:16369485]" /experiment="EXISTENCE:direct assay:GO:0042276 error-prone translesion synthesis [PMID:19776424]" /experiment="EXISTENCE:mutant phenotype:GO:0042276 error-prone translesion synthesis [PMID:19776424]" /experiment="EXISTENCE:mutant phenotype:GO:0045005 DNA-templated DNA replication maintenance of fidelity [PMID:19463834|PMID:18245343]" /note="Second largest subunit of DNA polymerase II (DNA polymerase epsilon); required for maintenance of fidelity of chromosomal replication; essential motif in C-terminus is required for formation of the four-subunit Pol epsilon; expression peaks at the G1/S phase boundary; Cdc28p substrate" /db_xref="GeneID:856305" /db_xref="SGD:S000006379" ORIGIN 1 mfgsgnvlpv kiqppllrpl ayrvlsrkyg lsiksdglsa laefvgtnig anwrqgpati 61 kfleqfaavw kqqerglfid qsgvkeviqe mkerekvews hehpiqheen ilgrtddden 121 nsddempiaa dsslqnvsls spmrqpterd eykqpfkpes skaldwrdyf kvinasqqqr 181 fsynphkmqf ifvpnkkqng lggiagflpd iedkvqmflt ryyltndrvm rnenfqnsdm 241 fnplssmvsl qnelsntnrq qqsssmsitp iknllgrdaq nflllgllnk nfkgnwsled 301 psgsveidis qtiptqghyy vpgcmvlveg iyysvgnkfh vtsmtlppge rreitletig 361 nldllgihgi snnnfiarld kdlkirlhll ekeltdhkfv ilganlfldd lkimtalski 421 lqklnddppt lliwqgsfts vpvfasmssr nissstqfkn nfdalatlls rfdnltentt 481 mifipgpndl wgsmvslgas gtlpqdpips aftkkinkvc knvvwssnpt riaylsqeiv 541 ifrddlsgrf krhrlefpfn esedvytend nmmskdtdiv pidelvkepd qlpqkvqetr 601 klvktildqg hlspfldslr piswdldhtl tlcpipstmv lcdttsaqfd ltyngckvin 661 pgsfihnrra rymeyvpssk ktiqeeiyi // LOCUS NP_015502 325 aa linear PLN 30-JUN-2025 DEFINITION Rab geranylgeranyltransferase BET2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015502 VERSION NP_015502.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184273.1 REFERENCE 1 (residues 1 to 325) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 325) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 325) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 325) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 325) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11593. Method: conceptual translation. FEATURES Location/Qualifiers source 1..325 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..325 /product="Rab geranylgeranyltransferase BET2" /EC_number="2.5.1.60" /calculated_mol_wt="36535" Region 7..297 /region_name="GGTase-II" /note="Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying...; cd02894" /db_xref="CDD:239224" Site order(30,33..34,37,41,84,86..87,89..90,137,140..141,183, 185,189,234,236..237,240,276,285..286) /site_type="active" /note="active site cavity [active]" /db_xref="CDD:239224" Site order(33..34,37,86..87,137,234,276) /site_type="active" /note="peptide binding pocket [active]" /db_xref="CDD:239224" Site order(37,40,137,140,183,185,189,228,231,237,240,285) /site_type="lipid-binding" /note="lipid binding pocket [chemical binding]" /db_xref="CDD:239224" Site order(132,170,180..181,186,213,216,218..219,228..230) /site_type="other" /note="heterodimer interface [polypeptide binding]" /db_xref="CDD:239224" Site order(234,236,286) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:239224" CDS 1..325 /gene="BET2" /locus_tag="YPR176C" /coded_by="NM_001184273.1:1..978" /experiment="EXISTENCE:direct assay:GO:0004663 Rab geranylgeranyltransferase activity [PMID:8756702]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005968 Rab-protein geranylgeranyltransferase complex [PMID:8183917|PMID:8756702|PMID:8583924]" /experiment="EXISTENCE:direct assay:GO:0018344 protein geranylgeranylation [PMID:8756702]" /experiment="EXISTENCE:direct assay:GO:0170069 geranylgeranyltransferase-III complex [PMID:40049413]" /experiment="EXISTENCE:mutant phenotype:GO:0006612 protein targeting to membrane [PMID:1903184]" /experiment="EXISTENCE:mutant phenotype:GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport [PMID:3312234|PMID:8232541]" /experiment="EXISTENCE:physical interaction:GO:0005968 Rab-protein geranylgeranyltransferase complex [PMID:8232542]" /note="Beta subunit of both type II and type III geranylgeranyltransferase complexes; provides a prenylated membrane attachment moiety for Rab-like proteins Ypt1p and Sec4p as part of GGTase-II; functions with alpha subunit Ecm9p (GGTase-III) in the transfer of a geranylgeranyl group to mono-farnsylated Ykt6p, regulating membrane localization and function in cell wall integrity and autophagy; required for vesicular transport between the ER and Golgi; human homolog RabGGTB, can complement yeast BET2 mutants" /db_xref="GeneID:856306" /db_xref="SGD:S000006380" ORIGIN 1 msgsltllke khiryiesld tkkhnfeywl tehlrlngiy wgltalcvld spetfvkeev 61 isfvlscwdd kygafapfpr hdahllttls avqilatyda ldvlgkdrkv rlisfirgnq 121 ledgsfqgdr fgevdtrfvy talsalsilg eltsevvdpa vdfvlkcynf dggfglcpna 181 eshaaqaftc lgalaiankl dmlsddqlee igwwlcerql pegglngrps klpdvcysww 241 vlsslaiigr ldwinyeklt efilkcqdek kggisdrpen evdvfhtvfg vaglslmgyd 301 nlvpidpiyc mpksvtskfk kypyk // LOCUS NP_015504 465 aa linear PLN 30-JUN-2025 DEFINITION U4/U6-U5 snRNP complex subunit PRP4 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015504 VERSION NP_015504.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184275.1 REFERENCE 1 (residues 1 to 465) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 465) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 465) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 465) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 465) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11594. Method: conceptual translation. FEATURES Location/Qualifiers source 1..465 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..465 /product="U4/U6-U5 snRNP complex subunit PRP4" /calculated_mol_wt="52311" Region <128..175 /region_name="HIP1_clath_bdg" /note="Clathrin-binding domain of Huntingtin-interacting protein 1; pfam16515" /db_xref="CDD:465154" Region 175..465 /region_name="WD40" /note="WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; cd00200" /db_xref="CDD:238121" Region 178..216 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Site order(192,196,202..203,216..217,236,240,246..247,263..264, 281,286,292..293,306,323,328,334..335,347..348,366,370, 376..377,391..392,411,416,422..423,435..436,454,458, 464..465) /site_type="active" /note="structural tetrad [active]" /db_xref="CDD:238121" Region 222..263 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 268..304 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 311..346 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 352..387 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 396..434 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" Region 440..464 /region_name="WD40 repeat" /note="WD40 repeat [structural motif]" /db_xref="CDD:293791" CDS 1..465 /gene="PRP4" /locus_tag="YPR178W" /gene_synonym="RNA4" /coded_by="NM_001184275.1:1..1398" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:mutant phenotype:GO:0000393 spliceosomal conformational changes to generate catalytic conformation [PMID:28864812]" /experiment="EXISTENCE:mutant phenotype:GO:0034247 snoRNA splicing [PMID:8202378]" /note="Splicing factor; component of the U4/U6-U5 snRNP complex" /db_xref="GeneID:856307" /db_xref="SGD:S000006382" ORIGIN 1 mskyialenl pvdlqhkgat qnestadilk qlpherlqav lekipeedle vrrllsilkk 61 pevvenedvq qrrirlaeil mvdeidleni nnmeningee vdeeddedff tpatselifa 121 rrflinysle rsrkrlqkem erhqkfntrq ellsrrtelq rmanlelags qlvstkpisa 181 vslstddmvv atgswagdlq vlnsqtlqpl tqkldshvgk igaidwhpds nnqmiscaed 241 gliknfqysn eegglrllgd lvgherrisd vkyhpsgkfi gsashdmtwr lwdasthqel 301 llqeghdkgv fslsfqcdgs lvcsggmdsl smlwdirsgs kvmtlaghsk piytvawspn 361 gyqvatgggd giinvwdirk rdegqlnqil ahrnivtqvr fskedggkkl vscgydnlin 421 vyssdtwlkm gslaghtdki isldisnnsh flvsggwdrs iklwn // LOCUS NP_015505 655 aa linear PLN 30-JUN-2025 DEFINITION Hda3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015505 VERSION NP_015505.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184276.1 REFERENCE 1 (residues 1 to 655) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 655) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 655) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 655) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 655) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11595. Method: conceptual translation. FEATURES Location/Qualifiers source 1..655 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..655 /product="Hda3p" /calculated_mol_wt="75332" Region 26..299 /region_name="HDA2-3" /note="Class II histone deacetylase complex subunits 2 and 3; pfam11496" /db_xref="CDD:402894" Region <466..600 /region_name="SMC_prok_B" /note="chromosome segregation protein SMC, common bacterial type; TIGR02168" /db_xref="CDD:274008" CDS 1..655 /gene="HDA3" /locus_tag="YPR179C" /gene_synonym="PLO1" /coded_by="NM_001184276.1:1..1968" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:19573535]" /experiment="EXISTENCE:direct assay:GO:0003682 chromatin binding [PMID:16415367]" /experiment="EXISTENCE:direct assay:GO:0004407 histone deacetylase activity [PMID:19573535]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14562095|PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0070823 HDA1 complex [PMID:11287668|PMID:8663039]" /experiment="EXISTENCE:mutant phenotype:GO:0000122 negative regulation of transcription by RNA polymerase II [PMID:11287668]" /experiment="EXISTENCE:mutant phenotype:GO:0007059 chromosome segregation [PMID:16415367]" /experiment="EXISTENCE:mutant phenotype:GO:0031047 regulatory ncRNA-mediated gene silencing [PMID:18022365]" /experiment="EXISTENCE:physical interaction:GO:0070823 HDA1 complex [PMID:11287668]" /note="Subunit of HDA1 histone deacetylase complex; tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for activity of complex; relocalizes to cytosol in response to hypoxia; similar to Hda2p; the HDA1 histone deacetylase complex regulates aging through trehalose metabolism" /db_xref="GeneID:856309" /db_xref="SGD:S000006383" ORIGIN 1 mdllrildtk piptivdatt lgisgntsgd ywlpttmsly qkeltdqivs lhysdilryf 61 etshykedvi lesmktmcln gslvathpyl lidhympksl itrdvpahla ensgkfsvlr 121 dlinlvqeye tetaivcrpg rtmdlleall lgnkvhikry dghsikskqk andfsctvhl 181 fsseginftk ypikskarfd mlicldttvd tsqkdiqyll qykrerkgle ryapivrlva 241 insidhcrlf fgkkfdknsr eylenvtaam vilrdrlgtl ppdlrpiysq klhylvewle 301 nptvpwplpd iyplkqytsm dverslltev hfkksddqle dafsncskkr grhgankaas 361 stvagiedni tpsfystkrl kndyytnplk qdmtqltgit tadnssnvny hlssgiithk 421 liqsmgevym dicvqkqeld dysclddlqn dhlkffsned ekiikeyetv lrtnnenlnr 481 shelevennl kfsqietlek dietlkgslm aqgetlsklk dafvktdnvq deiekeervs 541 vsrdtekkym eqeikravda ireneeethk lnekqngles elklkfekse istkelneki 601 gflkkelkle ndlneelvgq lsktmdnlen ltiprvrtqn gntkkksrak kpgnv // LOCUS NP_015506 347 aa linear PLN 30-JUN-2025 DEFINITION E1 ubiquitin-activating protein AOS1 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015506 VERSION NP_015506.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184277.1 REFERENCE 1 (residues 1 to 347) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 347) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 347) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 347) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 347) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11596. Method: conceptual translation. FEATURES Location/Qualifiers source 1..347 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..347 /product="E1 ubiquitin-activating protein AOS1" /calculated_mol_wt="39142" Region 13..345 /region_name="Aos1_SUMO" /note="Ubiquitin activating enzyme (E1) subunit Aos1. Aos1 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to...; cd01492" /db_xref="CDD:238769" Site order(15,17..23,25,47,50..51,54,70..71,73..75,77,84,95, 98..99,158,308,312,316,338) /site_type="other" /note="dimer interaction [polypeptide binding]" /db_xref="CDD:238769" CDS 1..347 /gene="AOS1" /locus_tag="YPR180W" /gene_synonym="RHC31" /coded_by="NM_001184277.1:1..1044" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:22932476|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:22932476]" /experiment="EXISTENCE:direct assay:GO:0016925 protein sumoylation [PMID:9312010]" /experiment="EXISTENCE:direct assay:GO:0019948 SUMO activating enzyme activity [PMID:9312010]" /experiment="EXISTENCE:physical interaction:GO:0031510 SUMO activating enzyme complex [PMID:9312010]" /note="Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability; relocalizes to the cytosol in response to hypoxia" /db_xref="GeneID:856310" /db_xref="SGD:S000006384" ORIGIN 1 mdmkveklse deialydrqi rlwgmtaqan mrsakvllin lgaigseitk sivlsgighl 61 tildghmvte edlgsqffig sedvgqwkid atkeriqdln prielnfdkq dlqekdeeff 121 qqfdlvvate mqideaikin tltrklnipl yvagsnglfa yvfidliefi sedeklqsvr 181 pttvgpissn rsiievttrk deedekktye riktkncyrp lnevlstatl kekmtqrqlk 241 rvtsilpltl sllqyglnqk gkaisfeqmk rdaavwcenl gvpatvvkdd yiqqfikqkg 301 iefapvaaii ggavaqdvin ilgkrlspln nfivfdgitl dmplfef // LOCUS NP_015507 768 aa linear PLN 30-JUN-2025 DEFINITION GTPase-activating protein SEC23 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015507 VERSION NP_015507.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184278.1 REFERENCE 1 (residues 1 to 768) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 768) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 768) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 768) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 768) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 768) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 768) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11597. Method: conceptual translation. FEATURES Location/Qualifiers source 1..768 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..768 /product="GTPase-activating protein SEC23" /calculated_mol_wt="85254" Region 1..767 /region_name="SEC23" /note="Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; COG5047" /db_xref="CDD:227380" CDS 1..768 /gene="SEC23" /locus_tag="YPR181C" /coded_by="NM_001184278.1:1..2307" /experiment="EXISTENCE:direct assay:GO:0003400 regulation of COPII vesicle coating [PMID:8451644]" /experiment="EXISTENCE:direct assay:GO:0005096 GTPase activator activity [PMID:8451644]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0030127 COPII vesicle coat [PMID:8004676]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:11694599]" /experiment="EXISTENCE:mutant phenotype:GO:0061709 reticulophagy [PMID:31273116]" /note="GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p" /db_xref="GeneID:856311" /db_xref="SGD:S000006385" ORIGIN 1 mdfetnedin gvrftwnvfp strsdansnv vpvgclytpl keydelnvap ynpvvcsgph 61 cksilnpycv idprnsswsc picnsrnhlp pqytnlsqen mplelqstti eyitnkpvtv 121 ppifffvvdl tsetenldsl kesiitslsl lppnaligli tygnvvqlhd lssetidrcn 181 vfrgdreyql ealtemltgq kptgpggaas hlpnamnkvt pfslnrfflp leqvefklnq 241 llenlspdqw svpaghrplr atgsalnias lllqgcykni pariilfasg pgtvapgliv 301 nselkdplrs hhdidsdhaq hykkackfyn qiaqrvaang htvdifagcy dqigmsemkq 361 ltdstggvll ltdafstaif kqsylrlfak deegylkmaf ngnmavktsk dlkvqgligh 421 asavkktdan niseseigig atstwkmasl spyhsyaiff eiantaansn pmmsapgsad 481 rphlaytqfi ttyqhssgtn rirvttvanq llpfgtpaia asfdqeaaav lmariavhka 541 etddgadvir wldrtliklc qkyadynkdd pqsfrlapnf slypqftyyl rrsqflsvfn 601 nspdetafyr hiftredttn slimiqptlt sfsmeddpqp vlldsisvkp ntillldtff 661 filiyhgeqi aqwrkagyqd dpqyadfkal leepkleaae llvdrfplpr fidteaggsq 721 arfllsklnp sdnyqdmarg gstivltddv slqnfmthlq qvavsgqa // LOCUS NP_015508 86 aa linear PLN 30-JUN-2025 DEFINITION mRNA splicing protein SMX3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015508 VERSION NP_015508.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184279.1 REFERENCE 1 (residues 1 to 86) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 86) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 86) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 86) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 86) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11598. Method: conceptual translation. FEATURES Location/Qualifiers source 1..86 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..86 /product="mRNA splicing protein SMX3" /calculated_mol_wt="9529" Region 14..83 /region_name="Sm_F" /note="Sm protein F; cd01722" /db_xref="CDD:212469" Site order(14..15,19,30..33,38,46,48..51,68..83) /site_type="other" /note="heptamer interface [polypeptide binding]" /db_xref="CDD:212469" Site order(27..33,36..48,50..54) /site_type="other" /note="Sm1 motif" /db_xref="CDD:212469" Site order(30,32..33,37,47..50,74..77) /site_type="other" /note="RNA binding site [nucleotide binding]" /db_xref="CDD:212469" Site 70..81 /site_type="other" /note="Sm2 motif" /db_xref="CDD:212469" CDS 1..86 /gene="SMX3" /locus_tag="YPR182W" /coded_by="NM_001184279.1:1..261" /experiment="EXISTENCE:curator inference:GO:0000398 mRNA splicing, via spliceosome []" /experiment="EXISTENCE:direct assay:GO:0005682 U5 snRNP [PMID:11720285|PMID:11720284]" /experiment="EXISTENCE:direct assay:GO:0005685 U1 snRNP [PMID:9630245]" /experiment="EXISTENCE:direct assay:GO:0005686 U2 snRNP [PMID:9012791]" /experiment="EXISTENCE:direct assay:GO:0008266 poly(U) RNA binding [PMID:12618433]" /experiment="EXISTENCE:direct assay:GO:0046540 U4/U6 x U5 tri-snRNP complex [PMID:10449419|PMID:10377396]" /experiment="EXISTENCE:physical interaction:GO:1990935 splicing factor binding [PMID:9528767]" /note="Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F" /db_xref="GeneID:856312" /db_xref="SGD:S000006386" ORIGIN 1 msessdisam qpvnpkpflk glvnhrvgvk lkfnsteyrg tlvstdnyfn lqlneaeefv 61 agvshgtlge ifircnnvly irelpn // LOCUS NP_015509 267 aa linear PLN 30-JUN-2025 DEFINITION dolichyl-phosphate beta-D-mannosyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015509 VERSION NP_015509.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184280.1 REFERENCE 1 (residues 1 to 267) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 267) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 267) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 267) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 267) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11599. Method: conceptual translation. FEATURES Location/Qualifiers source 1..267 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..267 /product="dolichyl-phosphate beta-D-mannosyltransferase" /EC_number="2.4.1.83" /calculated_mol_wt="30231" Region 7..234 /region_name="DPM1_like" /note="DPM1_like represents putative enzymes similar to eukaryotic DPM1; cd06442" /db_xref="CDD:133062" Site order(10,12,97) /site_type="active" /note="Ligand binding site [active]" /db_xref="CDD:133062" Site order(44,96..97) /site_type="active" /note="Putative Catalytic site [active]" /db_xref="CDD:133062" Site 95..97 /site_type="active" /note="DXD motif [active]" /db_xref="CDD:133062" CDS 1..267 /gene="DPM1" /locus_tag="YPR183W" /gene_synonym="SED3" /coded_by="NM_001184280.1:1..804" /experiment="EXISTENCE:direct assay:GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity [PMID:3053713|PMID:16549409]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:16823961]" /experiment="EXISTENCE:direct assay:GO:0005741 mitochondrial outer membrane [PMID:16407407]" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:1803815|PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network [PMID:10419517]" /experiment="EXISTENCE:direct assay:GO:0071944 cell periphery [PMID:26928762]" /experiment="EXISTENCE:mutant phenotype:GO:0006488 dolichol-linked oligosaccharide biosynthetic process [PMID:2146492]" /experiment="EXISTENCE:mutant phenotype:GO:0006506 GPI anchor biosynthetic process [PMID:2146492]" /note="Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane; catalyzes formation of Dol-P-Man from Dol-P and GDP-Man; required for biosynthesis of glycosyl phosphatidylinositol (GPI) membrane anchor, as well as O-mannosylation and protein N- and O-linked glycosylation; human homolog DPM1 can complement yeast mutant strains" /db_xref="GeneID:856313" /db_xref="SGD:S000006387" ORIGIN 1 msieysvivp ayheklnikp lttrlfagms pemakkteli fvddnsqdgs veevdalahq 61 gynvriivrt nerglssavl kgfyeakgqy lvcmdadlqh ppetvpklfe slhdhaftlg 121 tryapgvgid kdwpmyrrvi sstarmmarp ltiasdpmsg ffglqkkyle ncnprdinsq 181 gfkialella klplprdprv aigevpftfg vrtegeskls gkviiqylqq lkelyvfkfg 241 annlilfitf wsilffyvcy qlyhlvf // LOCUS NP_015510 1536 aa linear PLN 30-JUN-2025 DEFINITION bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015510 VERSION NP_015510.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184281.1 REFERENCE 1 (residues 1 to 1536) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1536) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1536) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1536) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1536) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11600. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1536 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1536 /product="bifunctional 4-alpha-glucanotransferase/amylo-alpha-1,6-glucosidase" /EC_number="2.4.1.25" /EC_number="3.2.1.33" /calculated_mol_wt="174841" Region 26..1528 /region_name="glyc_debranch" /note="glycogen debranching enzymye; TIGR01531" /db_xref="CDD:273673" CDS 1..1536 /gene="GDB1" /locus_tag="YPR184W" /coded_by="NM_001184281.1:1..4611" /experiment="EXISTENCE:direct assay:GO:0004134 4-alpha-glucanotransferase activity [PMID:11094287]" /experiment="EXISTENCE:direct assay:GO:0004135 amylo-alpha-1,6-glucosidase activity [PMID:11094287]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:22842922|PMID:14562095]" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:16823961]" /experiment="EXISTENCE:mutant phenotype:GO:0004134 4-alpha-glucanotransferase activity [PMID:11094287]" /experiment="EXISTENCE:mutant phenotype:GO:0004135 amylo-alpha-1,6-glucosidase activity [PMID:11094287]" /experiment="EXISTENCE:mutant phenotype:GO:0005980 glycogen catabolic process [PMID:11094287]" /note="Glycogen debranching enzyme; contains glucanotranferase and alpha-1,6-amyloglucosidase activities; required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p; protein abundance increases in response to DNA replication stress" /db_xref="GeneID:856314" /db_xref="SGD:S000006388" ORIGIN 1 mnrslllrls dtgepitscs ygkgvltlpp iplpkdapkd qplytvkllv sagspvardg 61 lvwtncppdh ntpfkrdkfy kkiihssfhe ddcidlnvya pgsycfylsf rndneklett 121 rkyyfvalpm lyindqflpl nsialqsvvs kwlgsdwepi lskiaaknyn mvhftplqer 181 gesnspysiy dqlqfdqehf kspedvknlv ehihrdlnml sltdivfnht annspwlveh 241 peagynhita phlisaield qellnfsrnl kswgyptelk niedlfkimd gikvhvlgsl 301 klweyyavnv qtalrdikah wndesnesys fpenikdiss dfvklasfvk dnvtepnfgt 361 lgernsnrin vpkfiqllkl indggsddse sslataqnil nevnlplyre ydddvseile 421 qlfnrikylr lddggpkqgp vtvdvpltep yftrfkgkdg tdyalanngw iwngnplvdf 481 asqnsraylr revivwgdcv klrygksped spylwermsk yiemnakifd gfridnchst 541 pihvgeyfld larkynpnly vvaelfsgse tldclfverl gissliream qawseeelsr 601 lvhkhggrpi gsykfvpmdd fsypadinln eehcfndsnd nsircvseim ipkiltatpp 661 halfmdcthd netpfekrtv edtlpnaalv alcssaigsv ygydeifphl lnlvtekrhy 721 distptgsps igitkvkatl nsirtsigek aydiedsemh vhhqgqyitf hrmdvksgkg 781 wyliarmkfs dnddpnetlp pvvlnqstcs lrfsyalerv gdeipnddkf ikgiptklke 841 legfdisydd skkistiklp nefpqgsiai fetqqngvde sldhfirsga lkatssltle 901 sinsvlyrse peeydvsage ggayiipnfg kpvycglqgw vsvlrkivfy ndlahplsan 961 lrnghwaldy tisrlnyysd eaginevqnw lrsrfdrvkk lpsylvpsyf aliigilygc 1021 crlkaiqlms rnigkstlfv qslsmtsiqm vsrmkstsil pgenvpsmaa glphfsvnym 1081 rcwgrdvfis lrgmllttgr fdeakahila faktlkhgli pnlldagrnp rynardaawf 1141 flqavqdyvy ivpdgekilq eqvtrrfpld dtyipvddpr afsysstlee iiyeilsrha 1201 kgikfreana gpnldrvmtd kgfnveihvd wstglihggs qyncgtwmdk mgesekagsv 1261 gipgtprdga aieingllks alrfvielkn kglfkfsdve tqdggridft ewnqllqdnf 1321 ekryyvpedp sqdadydvsa klgvnrrgiy rdlyksgkpy edyqlrpnfa iamtvapelf 1381 vpehaikait iadevlrgpv gmrtldpsdy nyrpyynnge dsddfatskg rnyhqgpewv 1441 wlygyflraf hhfhfktspr cqnaakekps sylyqqlyyr lkghrkwife svwagltelt 1501 nkdgevcnds sptqawssac lldlfydlwd ayedds // LOCUS NP_015511 738 aa linear PLN 30-JUN-2025 DEFINITION serine/threonine protein kinase regulatory subunit ATG13 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015511 VERSION NP_015511.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184282.1 REFERENCE 1 (residues 1 to 738) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 738) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 738) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 738) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 738) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 738) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 738) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11601. Method: conceptual translation. FEATURES Location/Qualifiers source 1..738 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..738 /product="serine/threonine protein kinase regulatory subunit ATG13" /calculated_mol_wt="83151" Region 15..261 /region_name="ATG13" /note="Autophagy-related protein 13; pfam10033" /db_xref="CDD:431003" CDS 1..738 /gene="ATG13" /locus_tag="YPR185W" /gene_synonym="APG13" /coded_by="NM_001184282.1:1..2217" /experiment="EXISTENCE:direct assay:GO:0000045 autophagosome assembly [PMID:18725539]" /experiment="EXISTENCE:direct assay:GO:0000407 phagophore assembly site [PMID:29540529]" /experiment="EXISTENCE:direct assay:GO:0005829 cytosol [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0019887 protein kinase regulator activity [PMID:22885598]" /experiment="EXISTENCE:direct assay:GO:0070016 armadillo repeat domain binding [PMID:31512555]" /experiment="EXISTENCE:direct assay:GO:0120095 vacuole-isolation membrane contact site [PMID:23549786]" /experiment="EXISTENCE:direct assay:GO:1990316 Atg1/ULK1 kinase complex [PMID:26753620]" /experiment="EXISTENCE:genetic interaction:GO:0034497 protein localization to phagophore assembly site [PMID:23509291]" /experiment="EXISTENCE:mutant phenotype:GO:0000422 autophagy of mitochondrion [PMID:19793921]" /experiment="EXISTENCE:mutant phenotype:GO:0006914 autophagy [PMID:32508216]" /experiment="EXISTENCE:mutant phenotype:GO:0006995 cellular response to nitrogen starvation [PMID:18725539]" /experiment="EXISTENCE:mutant phenotype:GO:0016236 macroautophagy [PMID:9224892]" /experiment="EXISTENCE:mutant phenotype:GO:0019887 protein kinase regulator activity [PMID:10995454]" /experiment="EXISTENCE:mutant phenotype:GO:0032258 cytoplasm to vacuole targeting by the Cvt pathway [PMID:27768871]" /experiment="EXISTENCE:mutant phenotype:GO:0034727 piecemeal microautophagy of the nucleus [PMID:18701704]" /experiment="EXISTENCE:mutant phenotype:GO:0044804 nucleophagy [PMID:22768199]" /experiment="EXISTENCE:mutant phenotype:GO:0071211 protein targeting to vacuole involved in autophagy [PMID:27768871]" /experiment="EXISTENCE:mutant phenotype:GO:0071255 Cvt vesicle assembly [PMID:10837477]" /experiment="EXISTENCE:physical interaction:GO:1990316 Atg1/ULK1 kinase complex [PMID:15743910]" /note="Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; contains a HORMA domain required for autophagy and for recruitment of the phosphatidylinositol 3-kinase complex subunit Atg14p to the pre-autophagosomal structure" /db_xref="GeneID:856315" /db_xref="SGD:S000006389" ORIGIN 1 mvaeediekq vlqlidsffl kttllicste ssryqssten iflfddtwfe dhselvselp 61 eiiskwshyd grkelpplvv etyldlrqln sshlvrlkdh eghlwnvckg tkkqeivmer 121 wlieldnssp tfksysedet dvnelskqlv llfrylltli qllpttelyq lliksyngpq 181 negssnpits tgplvsirtc vldgskpils kgriglskpi intysnalne snlpahldqk 241 kitpvwtkfg llrvsvsyrr dwkfeinntn delfsarhas vshnsqgpqn qpeqegqsdq 301 digkrqpqfq qqqqpqqqqq qqqqqqrqhq vqtqqqrqip drrslslspc transfepqs 361 wqkkvypisr pvqpfkvgsi gsqsasrnps nssffnqppv hrpsmssnyg pqmniegtsv 421 gstskysssf gnirrhssvk ttenaekvsk avksplqpqe sqedlmdfvk lleekpdlti 481 kktsgnnppn inisdsliry qnlkpsndll sedlsvslsm dpnhtyhrgr sdshsplpsi 541 spsmhygsln srmsqganas hliargggns stsalnsrrn sldkssnkqg msglppifgg 601 estsyhhdnk iqkynqlgve eddddendrl lnqmgnsatk fkssisprsi dsisssfiks 661 ripirqpyhy sqpttapfqa qakfhkpank lidngnrsns nnnnhngnda vgvmhndedd 721 qdddlvffms dmnlskeg // LOCUS NP_015512 429 aa linear PLN 30-JUN-2025 DEFINITION Pzf1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015512 VERSION NP_015512.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184283.1 REFERENCE 1 (residues 1 to 429) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 429) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 429) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 429) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 429) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11602. Method: conceptual translation. FEATURES Location/Qualifiers source 1..429 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..429 /product="Pzf1p" /calculated_mol_wt="49896" Region 46..427 /region_name="COG5048" /note="FOG: Zn-finger [General function prediction only]" /db_xref="CDD:227381" Region 54..74 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(58,60,62,64..65,68..69,73,87,89,93..94,97..98,101, 115,117,119,121..122,125..126,129) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 82..102 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 110..130 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 136..155 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 165..185 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Site order(170,172,174,176..177,180..181,184,203,205,209..210, 213..214,229,231,233,235..236,239..240,243) /site_type="other" /note="putative nucleic acid binding site [nucleotide binding]" /db_xref="CDD:275368" Region 196..216 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 224..244 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" Region 255..277 /region_name="C2H2 Zn finger" /note="C2H2 Zn finger [structural motif]" /db_xref="CDD:275368" CDS 1..429 /gene="PZF1" /locus_tag="YPR186C" /gene_synonym="TFC2" /coded_by="NM_001184283.1:1..1290" /experiment="EXISTENCE:curator inference:GO:0005634 nucleus [PMID:2642897]" /experiment="EXISTENCE:direct assay:GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding [PMID:2642897]" /experiment="EXISTENCE:direct assay:GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [PMID:8496187]" /experiment="EXISTENCE:direct assay:GO:0042791 5S class rRNA transcription by RNA polymerase III [PMID:2642897]" /experiment="EXISTENCE:mutant phenotype:GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity [PMID:8496187]" /note="Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA" /db_xref="GeneID:856316" /db_xref="SGD:S000006390" ORIGIN 1 mggevlnneg mplaelkqet ipisrsesse slnsltstrs sssnrpktyf cdydgcdkaf 61 trpsiltehq lsvhqglraf qcdkcaksfv kkshlerhly thsdtkpfqc sycgkgvttr 121 qqlkrhevth tksficpeeg cnlrfykhpq lrahilsvhl hkltcphcnk sfqrpyrlrn 181 hiskhhdpev enpyqctfag cckefriwsq lqshikndhp klkcpicskp cvgenglqmh 241 miihddslvt knwkchicpd msfsrkhdll thygsihtee diplelkyki sdiqqlvqdh 301 gvqlgnskhs neqdeekisn rlrkrrklte nnnveflqne vdlekrlesg englnlllnt 361 vgrkyrcfyn ncsrtfktke kyekhidkhk vhelklkilq ekeenktlvd qnhkepfiiq 421 ketqsagdk // LOCUS NP_015513 155 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase core subunit RPO26 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015513 VERSION NP_015513.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184284.1 REFERENCE 1 (residues 1 to 155) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 155) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 155) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 155) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 155) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11603. Method: conceptual translation. FEATURES Location/Qualifiers source 1..155 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..155 /product="DNA-directed RNA polymerase core subunit RPO26" /calculated_mol_wt="17779" Region <70..154 /region_name="PLN00152" /note="DNA-directed RNA polymerase; Provisional" /db_xref="CDD:177755" CDS 1..155 /gene="RPO26" /locus_tag="YPR187W" /gene_synonym="RPB6" /coded_by="NM_001184284.1:1..468" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793|PMID:8288647|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0003968 RNA-directed RNA polymerase activity [PMID:18004386]" /experiment="EXISTENCE:direct assay:GO:0005665 RNA polymerase II, core complex [PMID:2183013|PMID:1331084|PMID:2186966]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:10611227|PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005736 RNA polymerase I complex [PMID:11486042|PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0006360 transcription by RNA polymerase I [PMID:9837969]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0006366 transcription by RNA polymerase II [PMID:12697831]" /experiment="EXISTENCE:mutant phenotype:GO:0006383 transcription by RNA polymerase III [PMID:12697831]" /note="RNA polymerase subunit ABC23; common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit" /db_xref="GeneID:856317" /db_xref="SGD:S000006391" ORIGIN 1 msdyeeafnd gnenfedfdv ehfsdeetye ekpqfkdget tdangktivt ggngpedfqq 61 heqirrktlk ekaipkdqra ttpymtkyer arilgtralq ismnapvfvd legetdplri 121 amkelaekki plvirrylpd gsfedwsvee livdl // LOCUS NP_015514 163 aa linear PLN 30-JUN-2025 DEFINITION Mlc2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015514 VERSION NP_015514.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184285.1 REFERENCE 1 (residues 1 to 163) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 163) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 163) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 163) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 163) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11604. Method: conceptual translation. FEATURES Location/Qualifiers source 1..163 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..163 /product="Mlc2p" /calculated_mol_wt="18389" Region 10..>109 /region_name="PTZ00184" /note="calmodulin; Provisional" /db_xref="CDD:185504" CDS 1..163 /gene="MLC2" /locus_tag="YPR188C" /coded_by="NM_001184285.1:1..492" /experiment="EXISTENCE:direct assay:GO:0000131 incipient cellular bud site [PMID:15210731]" /experiment="EXISTENCE:direct assay:GO:0000142 cellular bud neck contractile ring [PMID:15210731]" /experiment="EXISTENCE:genetic interaction:GO:1902404 mitotic actomyosin contractile ring contraction [PMID:19109423]" /experiment="EXISTENCE:mutant phenotype:GO:1902404 mitotic actomyosin contractile ring contraction [PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0005515 protein binding [PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0016460 myosin II complex [PMID:15210731]" /experiment="EXISTENCE:physical interaction:GO:0032038 myosin II heavy chain binding [PMID:15210731]" /note="Regulatory light chain for the type II myosin Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring" /db_xref="GeneID:856318" /db_xref="SGD:S000006392" ORIGIN 1 mdhsesltfn qltqdyinkl kdafqmlded edglisrgdl tkiyatlgkt ltdeewskmv 61 pdndtstaev geegvsfpif lsimgknlsq fpereelees lkaigrghdl nvplnevids 121 lkeagfenpe eefaklfklf ttnqqateer tfrgklflds itd // LOCUS NP_015515 1432 aa linear PLN 30-JUN-2025 DEFINITION SKI complex subunit tetratricopeptide repeat protein SKI3 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015515 VERSION NP_015515.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184286.1 REFERENCE 1 (residues 1 to 1432) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1432) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1432) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1432) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1432) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11605. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1432 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1432 /product="SKI complex subunit tetratricopeptide repeat protein SKI3" /calculated_mol_wt="163596" Region 2..>87 /region_name="BepA" /note="Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones]; COG4783" /db_xref="CDD:443813" Region 7..32 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 37..76 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 151..241 /region_name="TPR_22" /note="Tetratricopeptide repeat; pfam18833" /db_xref="CDD:436771" Region <412..>836 /region_name="PEP_TPR_lipo" /note="putative PEP-CTERM system TPR-repeat lipoprotein; TIGR02917" /db_xref="CDD:274350" Region 507..537 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 542..570 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 620..>804 /region_name="TPR" /note="Tetratricopeptide (TPR) repeat [General function prediction only]; COG0457" /db_xref="CDD:440225" Site order(710..711,713,737,740..741,744..745,747..748,771, 774..775,778..779,782) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 735..765 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 770..798 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 945..980 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Region 970..>1068 /region_name="NrfG" /note="Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]; COG4235" /db_xref="CDD:443378" Region 986..1013 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" Site order(987,990..991,994..995,997,1020,1023..1024,1027..1028, 1030..1031,1054,1057..1058,1061..1062,1065) /site_type="other" /note="putative protein binding surface [polypeptide binding]" /db_xref="CDD:276809" Region 1018..1325 /region_name="LapB" /note="Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis]; COG2956" /db_xref="CDD:442196" Region 1018..1048 /region_name="TPR repeat" /note="TPR repeat [structural motif]" /db_xref="CDD:276809" CDS 1..1432 /gene="SKI3" /locus_tag="YPR189W" /gene_synonym="SKI5" /coded_by="NM_001184286.1:1..4299" /experiment="EXISTENCE:direct assay:GO:0055087 Ski complex [PMID:18042677|PMID:10744028]" /experiment="EXISTENCE:genetic interaction:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0000956 nuclear-transcribed mRNA catabolic process [PMID:10611222|PMID:9482746]" /experiment="EXISTENCE:mutant phenotype:GO:0070478 nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay [PMID:12881429]" /experiment="EXISTENCE:mutant phenotype:GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay [PMID:11910110|PMID:17660569]" /experiment="EXISTENCE:physical interaction:GO:0055087 Ski complex [PMID:18042677]" /note="Ski complex component and TPR protein; mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay; role in preventing L-A mycovirus pathogenesis; mutations in the human ortholog, TTC37, causes Syndromic diarrhea/Trichohepatoenteric (SD/THE) syndrome" /db_xref="GeneID:856319" /db_xref="SGD:S000006393" ORIGIN 1 msdikqllke akqeltnrdy eetieisekv lkldpdnyfa hiflgkalss lpasnnvssn 61 rnleratnhy vsaaklvpdn llawkglfll frttevvpdi lsydeyfdlc gqyadallkq 121 eqsqvelind ikllkkthpd cqkafyqhlk pgslmaetig rhlstpqdal lnlikilsni 181 etteigktls qnrlklkasd pdyqiklnsf sweiiknsei dqlynqlvni laddqkrsei 241 enqwleyrik vlksmpldvk kdfftkvkem vedmvlvnhq sllawqkyfe wtdyedldnm 301 dapliikyfk kfpkdplami lyswlsskls kydikslesa nkppeghkkt eketdikdvd 361 etnedevkdr vedevkdrve devkdqdeea kedeeedldd ieiglleeev vtvltenivk 421 cknnilahri lcqyylltke yeaalpyikn gisliaynik dlgvhlpltk refsldlatv 481 ytyvdapkdh naalklydni lsgdfsniqa kmgkgiifie rknwkdamtl ltqvheqspn 541 nlevlselsw skahmgymde alagldtvik gikgmdlrsi dfralnlwrq akvyimkhas 601 indakqenvk cafklliqsi kildtfapgf stlgdiychy ykdhlrafkc yfkafdldag 661 dytaakyite tyaskpnwqa assiasrlik gekakaelrs nnwpfrvvgi ahlekqeesd 721 siewfqsalr vdpndveswv glgqayhacg rieasikvfd kaiqlrpsht faqyfkaisl 781 cdvgeylesl dilekvcqea ateesfqigl vevlmrcsld lysqgfllks vsiakdtier 841 ikiiiselkc enqqvwiyls qvlrlfiwie skvdtlpves lvsifensqf sgseeidsvd 901 nikidtllds ttddnvsiac kflilaskys vsdqkftdia gtvrasywyn igiseltafi 961 tlkepqyrda aifafkksiq lqsntsetwi glgiatmdin frvsqhcfik atalepkatn 1021 twfnlamlgl kkkdtefaqq vlnklqslap qdsspwlgma lileeqgdii gssklfahsf 1081 ilsngrskaa qfmyaknvle nhinngdder dietvekltt asialeqffk kspdsqfalq 1141 calltlerlh hyenanelan rligilekkf ektqderelf nfaiikgqfa rihlglgnfe 1201 lsienadlsq giisessdek smktkisnhi clglsyffln dfdqtlnqfq ellsiskdsk 1261 hlvvliakvl ydvgesdtke ialqelteyi atsgadllvt ltiaamsild dkredlsiil 1321 eelkalplsk qiidkhkdap ylieeitkrl yrndtgkqvw qrsayffpnn lkvwerldkn 1381 iqrriasngq nkvtaeemsk lycesknlrs iqrgmflcpw nvtavkalne cf // LOCUS NP_015516 654 aa linear PLN 30-JUN-2025 DEFINITION DNA-directed RNA polymerase III subunit C82 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015516 VERSION NP_015516.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184287.1 REFERENCE 1 (residues 1 to 654) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 654) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 654) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 654) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 654) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11606. Method: conceptual translation. FEATURES Location/Qualifiers source 1..654 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..654 /product="DNA-directed RNA polymerase III subunit C82" /calculated_mol_wt="73886" Region 47..109 /region_name="HTH_9" /note="RNA polymerase III subunit RPC82 helix-turn-helix domain; pfam08221" /db_xref="CDD:400500" Region 189..487 /region_name="RNA_pol_Rpc82" /note="RNA polymerase III subunit RPC82; pfam05645" /db_xref="CDD:398977" CDS 1..654 /gene="RPC82" /locus_tag="YPR190C" /gene_synonym="RPC3; RPC80" /coded_by="NM_001184287.1:1..1965" /experiment="EXISTENCE:direct assay:GO:0003899 DNA-directed RNA polymerase activity [PMID:3905793]" /experiment="EXISTENCE:direct assay:GO:0005666 RNA polymerase III complex [PMID:3905793|PMID:10611227]" /experiment="EXISTENCE:direct assay:GO:0042797 tRNA transcription by RNA polymerase III [PMID:3905793]" /experiment="EXISTENCE:mutant phenotype:GO:0042797 tRNA transcription by RNA polymerase III [PMID:1406632]" /note="RNA polymerase III subunit C82" /db_xref="GeneID:856320" /db_xref="SGD:S000006394" ORIGIN 1 mdellgeals aenqtgestv eseklvtped vmtissleqr tlnpdlflyk elvkahlger 61 aasvigmlva lgrlsvrelv ekidgmdvds vkttlvsltq lrcvkylqet aisgkkttyy 121 yyneegihil lysgliidei itqmrvndee ehkqlvaeiv qnvislgslt vedylssvts 181 dsmkytissl fvqlcemgyl iqisklhytp iedlwqflye khykniprns plsdlkkrsq 241 akmnaktdfa kiinkpnels qiltvdpkts lrivkptvsl tinldrfmkg rrskqlinla 301 ktrvgsvtaq vykialrlte qkspkirdpl tqtgllqdle eaksfqdeae lveektpglt 361 fnaidlarhl paeldlrgsl lsrkpsdnkk rsgsnaaasl pskklktedg fvipalpaav 421 skslqesgdt qeedeeeedl dadtedphsa slinshlkil assnfpflne tkpgvyyvpy 481 sklmpvlkss vyeyviastl gpsamrlsrc irdnklvsek iinstalmke kdirstlasl 541 irynsveiqe vprtadrsas ravflfrcke thsynfmrqn lewnmanllf kkeklkqens 601 tllkkanrdd vkgrenelll pselnqlkmv nerelnvfar lsrllslwev fqma // LOCUS NP_015517 368 aa linear PLN 30-JUN-2025 DEFINITION ubiquinol--cytochrome-c reductase subunit 2 [Saccharomyces cerevisiae S288C]. ACCESSION NP_015517 VERSION NP_015517.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184288.1 REFERENCE 1 (residues 1 to 368) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 368) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 368) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 368) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 368) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11607. Method: conceptual translation. FEATURES Location/Qualifiers source 1..368 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..368 /product="ubiquinol--cytochrome-c reductase subunit 2" /calculated_mol_wt="40347" Region 17..163 /region_name="Peptidase_M16" /note="Insulinase (Peptidase family M16); pfam00675" /db_xref="CDD:425812" Region 19..334 /region_name="PqqL" /note="Predicted Zn-dependent peptidase, M16 family [General function prediction only]; COG0612" /db_xref="CDD:440377" CDS 1..368 /gene="QCR2" /locus_tag="YPR191W" /gene_synonym="COR2; UCR2" /coded_by="NM_001184288.1:1..1107" /experiment="EXISTENCE:direct assay:GO:0005739 mitochondrion [PMID:14576278|PMID:24769239|PMID:11502169|PMID:11914276|P MID:16823961]" /experiment="EXISTENCE:direct assay:GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c [PMID:3028797]" /experiment="EXISTENCE:direct assay:GO:0030061 mitochondrial crista [PMID:19019989]" /experiment="EXISTENCE:direct assay:GO:0045275 respiratory chain complex III [PMID:10873857]" /experiment="EXISTENCE:mutant phenotype:GO:0008121 quinol-cytochrome-c reductase activity [PMID:3028797]" /experiment="EXISTENCE:mutant phenotype:GO:0009060 aerobic respiration [PMID:3028797]" /note="Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme" /db_xref="GeneID:856321" /db_xref="SGD:S000006395" ORIGIN 1 mlsaarlqfa qgsvrrltvs ardaptkist lavkvhggsr yatkdgvahl lnrfnfqntn 61 trsalklvre sellggtfks tldreyitlk atflkddlpy yvnaladvly ktafkphelt 121 esvlpaaryd yavaeqcpvk saedqlyait frkglgnpll ydgvervslq dikdfadkvy 181 tkenlevsge nvveadlkrf vdesllstlp agkslvskse pkfflgeenr vrfigdsvaa 241 igipvnkasl aqyevlanyl tsalselsgl issakldkft dgglftlfvr dqdsavvssn 301 ikkivadlkk gkdlspainy tklknavqne svsspielnf davkdfklgk fnyvavgdvs 361 nlpyldel // LOCUS NP_015518 305 aa linear PLN 30-JUN-2025 DEFINITION Aqy1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015518 VERSION NP_015518.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184289.1 REFERENCE 1 (residues 1 to 305) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 305) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 305) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 305) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 305) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11608. Method: conceptual translation. FEATURES Location/Qualifiers source 1..305 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..305 /product="Aqy1p" /calculated_mol_wt="32582" Region 54..266 /region_name="MIP" /note="MIP family channel proteins; TIGR00861" /db_xref="CDD:273306" Site order(98,116..118,226..227,230,233) /site_type="active" /note="amphipathic channel [active]" /db_xref="CDD:238204" Site order(118..120,230..232) /site_type="other" /note="Asn-Pro-Ala signature motifs" /db_xref="CDD:238204" CDS 1..305 /gene="AQY1" /locus_tag="YPR192W" /coded_by="NM_001184289.1:1..918" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:10092523]" /experiment="EXISTENCE:direct assay:GO:0055085 transmembrane transport [PMID:9765289]" /experiment="EXISTENCE:genetic interaction:GO:0015250 water channel activity [PMID:11158584]" /experiment="EXISTENCE:genetic interaction:GO:0055085 transmembrane transport [PMID:11158584]" /experiment="EXISTENCE:mutant phenotype:GO:0006833 water transport [PMID:9765289]" /experiment="EXISTENCE:mutant phenotype:GO:0015250 water channel activity [PMID:9765289]" /experiment="EXISTENCE:mutant phenotype:GO:0030437 ascospore formation [PMID:15583134]" /note="Spore-specific water channel; mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance" /db_xref="GeneID:856322" /db_xref="SGD:S000006396" ORIGIN 1 mssndsndtd kqhtrldptg vddayippeq petkhhrfki srdtlrdhfi aavgefcgtf 61 mflwcayvic nvanhdvalv aapdgshpgq limiaigfgf svmfsiwcfa gvsggalnpa 121 mslslclara vsptrcvvmw vsqivagmaa ggaasamtpg evlfanslgl gcsrtrglfl 181 emfgtailcl tvlmtavekr etnfmaalpi gislfiahva ltaytgtgvn parslgaava 241 aryfphyhwi ywigtllgsi lawsvwqllq ildyttyvta ekaastkeka qkkgetssss 301 avaev // LOCUS NP_015519 156 aa linear PLN 30-JUN-2025 DEFINITION histone acetyltransferase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015519 VERSION NP_015519.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184290.1 REFERENCE 1 (residues 1 to 156) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 156) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 156) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 156) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 156) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11609. Method: conceptual translation. FEATURES Location/Qualifiers source 1..156 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..156 /product="histone acetyltransferase" /EC_number="2.3.1.48" /calculated_mol_wt="18203" Region 22..144 /region_name="Acetyltransf_1" /note="Acetyltransferase (GNAT) family; pfam00583" /db_xref="CDD:395465" Site order(93..95,105..106) /site_type="other" /note="Coenzyme A binding pocket [chemical binding]" /db_xref="CDD:173926" CDS 1..156 /gene="HPA2" /locus_tag="YPR193C" /gene_synonym="KAT10" /coded_by="NM_001184290.1:1..471" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:11914276]" /experiment="EXISTENCE:direct assay:GO:0006473 protein acetylation [PMID:23775086]" /experiment="EXISTENCE:direct assay:GO:0008080 N-acetyltransferase activity [PMID:23775086]" /note="Tetrameric histone acetyltransferase; has similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity; also acetylates polyamines" /db_xref="GeneID:856323" /db_xref="SGD:S000006397" ORIGIN 1 msntsednit vrfvtendke gwqrlwksyq dfyevsfpdd lddfnfgrfl dpnikmwaav 61 avesssekii gminffnhmt twdfkdkiyi ndlyvdensr vkgaggkliq fvydeadklg 121 tpsvywctde snhraqllyv kvgykapkil ykrkgy // LOCUS NP_015520 877 aa linear PLN 30-JUN-2025 DEFINITION Opt2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015520 VERSION NP_015520.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184291.1 REFERENCE 1 (residues 1 to 877) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 877) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 877) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 877) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 877) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 877) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 877) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11610. Method: conceptual translation. FEATURES Location/Qualifiers source 1..877 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..877 /product="Opt2p" /calculated_mol_wt="101131" Region 141..839 /region_name="OPT" /note="OPT oligopeptide transporter protein; cl14607" /db_xref="CDD:449333" CDS 1..877 /gene="OPT2" /locus_tag="YPR194C" /coded_by="NM_001184291.1:1..2634" /experiment="EXISTENCE:direct assay:GO:0000138 Golgi trans cisterna [PMID:25359886]" /experiment="EXISTENCE:direct assay:GO:0000324 fungal-type vacuole [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005777 peroxisome [PMID:25130273]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:25359886]" /experiment="EXISTENCE:direct assay:GO:0006857 oligopeptide transport [PMID:9643541]" /experiment="EXISTENCE:direct assay:GO:0035673 oligopeptide transmembrane transporter activity [PMID:9643541]" /experiment="EXISTENCE:genetic interaction:GO:0044088 regulation of vacuole organization [PMID:25359886]" /experiment="EXISTENCE:genetic interaction:GO:0061091 regulation of phospholipid translocation [PMID:25359886]" /experiment="EXISTENCE:mutant phenotype:GO:0042144 vacuole fusion, non-autophagic [PMID:19767828]" /experiment="EXISTENCE:mutant phenotype:GO:0045454 cell redox homeostasis [PMID:25130273]" /experiment="EXISTENCE:mutant phenotype:GO:0051515 positive regulation of monopolar cell growth [PMID:25359886]" /note="Oligopeptide transporter; localized to peroxisomes and affects glutathione redox homeostasis; also localizes to the plasma membrane (PM) and to the late Golgi, and has a role in maintenance of lipid asymmetry between the inner and outer leaflets of the PM; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles and in polarized cell growth" /db_xref="GeneID:856324" /db_xref="SGD:S000006398" ORIGIN 1 msetvkdkvi idekvstkgt vdyaegaeys erlsnhssdf sqwytdeqil hfmkklgyen 61 rtlydipedv ayilkkmpel tledsfkilk dsiiyfkdde niphdqyeew krlvdledld 121 skegideyds fdirafasai kfhspyqevr avvdpeddpt ipvetfrayf laiiwsvigs 181 gfneffshrv vsislntpii qmflyicgka waktipcwti tirgrkygin idkpwtqkeq 241 mfstllyaic qgafythyni ltqklfyhsa fsfgyqflls lsvqfigfgf agilrkfvvy 301 paralwptvm ptiainkall gkekhesgms rykfffltff imfiynwfpt yiinilntfn 361 wmtwikpsni nlanitggvt glginpissf dwnvisfnsp lvypfwsylt qylgcilaal 421 iviavyysny mscqylpift nslytntghs fkvtevldsd nkldvkkyqs ysppyysagn 481 lvsygafica yplmitwsfi vhskllfnaf kdwalnlwam rklkswvtmf ksdyralddy 541 ddphsnamkn ykevpdwwyf ailigslvvg iavvehyptn tpvwglfvcl gfnfvflipt 601 tilqattgys fglnlliemv mgyalpgnpi aimilkafgy nidgqadnyv snlkiahyck 661 ippmalfrgq cvivfiqifv nlgvlnwqis nikdfctphq nakftcpdav tyynasvvwg 721 aigpkrifny iypifkwcwl igacigiffg vwkrwgkfyp ryfdpmlfvg gmlnmsppyn 781 lmyytsgmiv syisqyymkr hhlnlwekyn yvlsagfstg lvlsaiiiff avqykdtafn 841 wwgntvpyag adgvgyplkn itdtangyfg yapghyp // LOCUS NP_015522 470 aa linear PLN 30-JUN-2025 DEFINITION putative maltose-responsive transcription factor [Saccharomyces cerevisiae S288C]. ACCESSION NP_015522 VERSION NP_015522.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184293.1 REFERENCE 1 (residues 1 to 470) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 470) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 470) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 470) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 470) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11611. Method: conceptual translation. FEATURES Location/Qualifiers source 1..470 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..470 /product="putative maltose-responsive transcription factor" /calculated_mol_wt="54946" Region 4..43 /region_name="GAL4" /note="GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; smart00066" /db_xref="CDD:214501" Site order(7,12..15,17,20,29) /site_type="DNA binding" /note="DNA binding site [nucleotide binding]" /db_xref="CDD:238023" Site order(8,11,18,24,27,34) /site_type="other" /note="Zn2+ binding site [ion binding]" /db_xref="CDD:238023" Region 79..>270 /region_name="fungal_TF_MHR" /note="fungal transcription factor regulatory middle homology region; cd12148" /db_xref="CDD:213391" CDS 1..470 /locus_tag="YPR196W" /coded_by="NM_001184293.1:1..1413" /experiment="EXISTENCE:direct assay:GO:0043565 sequence-specific DNA binding [PMID:19111667]" /note="Putative maltose-responsive transcription factor" /db_xref="GeneID:856326" /db_xref="SGD:S000006400" ORIGIN 1 msivrqscdc crvrrvkcdr nrpcdrcrqr nlrctylqpl rkrgpksige snleraaeiq 61 mvtvnnnima apvmykkvpk kvidqclrly hdqlyviwpm lsyddlykll eenyedcsty 121 wflvslsaat lsdlhtkiey kkgfffageq lcnlcmssrr ffddlsnsdi frimtyyclh 181 rcyaqfadtr tsyrlsceai glikiagfhr eetyeflpfg eqqlirkvyy lllmteryya 241 vyikcvtsld ttisppqpei vtdsrlslds flevikvftv pgkyfydala tnsvngsyte 301 dslkriwnel hissldiepy sygyidylfs rhwvrtlawk lvlnkkdmrm nffsntnath 361 ipveiakdml qdtlltpidl ydvhgpvipm kaleianalv dvvskydhnm kleawnilcd 421 vskfvfslkh cnhkmfqrfs tkcqsalidl pisrplrlnd dskdevdiip // LOCUS NP_015524 543 aa linear PLN 30-JUN-2025 DEFINITION Sge1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015524 VERSION NP_015524.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184295.1 REFERENCE 1 (residues 1 to 543) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 543) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 543) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 543) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 543) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11612. Method: conceptual translation. FEATURES Location/Qualifiers source 1..543 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..543 /product="Sge1p" /calculated_mol_wt="59295" Region 24..531 /region_name="MFS_Azr1_MDR_like" /note="Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; cd17502" /db_xref="CDD:341045" Site order(25..26,29,60,110..111,113..115,118,138,141..142,145, 314,317..318,321..323,326,354,358,409..410,414,418,440, 443..444,447..448,451) /site_type="other" /note="putative chemical substrate binding pocket [chemical binding]" /db_xref="CDD:341045" CDS 1..543 /gene="SGE1" /locus_tag="YPR198W" /gene_synonym="NOR1" /coded_by="NM_001184295.1:1..1632" /experiment="EXISTENCE:direct assay:GO:0005783 endoplasmic reticulum [PMID:26928762]" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:9483795]" /experiment="EXISTENCE:mutant phenotype:GO:0042910 xenobiotic transmembrane transporter activity [PMID:9483795]" /experiment="EXISTENCE:mutant phenotype:GO:0055085 transmembrane transport [PMID:9483795]" /note="Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations" /db_xref="GeneID:856327" /db_xref="SGD:S000006402" ORIGIN 1 mkstlsltlc visllltlfl aaldivivvt lydtigikfh dfgnigwlvt gyalsnavfm 61 llwgrlaeil gtkeclmisv ivfeigslis alsnsmatli sgrvvagfgg sgieslafvv 121 gtsivrenhr gimitalais yviaegvgpf iggafnehls wrwcfyinlp igafafiila 181 fcntsgephq kmwlpskikk imnydygell kasfwkntfe vlvfkldmvg iilssagftl 241 lmlglsfggn nfpwnsgiii cfftvgpill llfcaydfhf lslsglhydn krikplltwn 301 iasncgifts sitgflscfa yelqsaylvq lyqlvfkkkp tlasihlwel sipamiatma 361 iaylnskygi ikpaivfgvl cgivgsglft lingelsqsi gysilpgiaf gsifqatlls 421 sqvqitsddp dfqnkfievt afnsfakslg fafggnmgam iftaslknqm rssqlnipqf 481 tsvetllays tehydgpqss lskfintaih dvfycalgcy alsfffgift sskkttisak 541 kqq // LOCUS NP_015525 294 aa linear PLN 30-JUN-2025 DEFINITION Arr1p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015525 VERSION NP_015525.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184296.1 REFERENCE 1 (residues 1 to 294) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 294) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 294) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 294) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 294) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11613. Method: conceptual translation. FEATURES Location/Qualifiers source 1..294 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..294 /product="Arr1p" /calculated_mol_wt="33096" CDS 1..294 /gene="ARR1" /locus_tag="YPR199C" /gene_synonym="ACR1; YAP8" /coded_by="NM_001184296.1:1..885" /experiment="EXISTENCE:direct assay:GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding [PMID:18593383]" /experiment="EXISTENCE:direct assay:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:18593383]" /experiment="EXISTENCE:direct assay:GO:0003677 DNA binding [PMID:24358276]" /experiment="EXISTENCE:direct assay:GO:0005634 nucleus [PMID:14978214|PMID:15147884]" /experiment="EXISTENCE:direct assay:GO:0005737 cytoplasm [PMID:15147884]" /experiment="EXISTENCE:genetic interaction:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:14978214|PMID:11527213]" /experiment="EXISTENCE:genetic interaction:GO:0071243 cellular response to arsenic-containing substance [PMID:11527213|PMID:14978214]" /experiment="EXISTENCE:mutant phenotype:GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific [PMID:18593383]" /experiment="EXISTENCE:mutant phenotype:GO:0045944 positive regulation of transcription by RNA polymerase II [PMID:18593383|PMID:15575969|PMID:14978214|PMID:15147884|P MID:11527213]" /experiment="EXISTENCE:mutant phenotype:GO:0071243 cellular response to arsenic-containing substance [PMID:15147884|PMID:18593383|PMID:11527213|PMID:15575969]" /note="Transcriptional activator of the basic leucine zipper (bZIP) family; required for transcription of genes involved in resistance to arsenic compounds; directly binds trivalent arsenic (As(III)) as does K. lactis ortholog, KIYAP8" /db_xref="GeneID:856329" /db_xref="SGD:S000006403" ORIGIN 1 makprgrkgg rkpsltppkn kraaqlrasq nafrkrkler leelekkeaq ltvtndqihi 61 lkkenellhf mlrslltern mpsdernisk acceekpptc ntldgsvvls stynsleiqq 121 cyvffkqlls vcvgknctvp splnsfdrsf ypigctnlsn dipgysflnd amseihtfgd 181 fngeldstfl efsgteikep nnfitentna ietaaasmvi rqgfhprqyy tvdafggdvl 241 lsamdiwsfm kvhpkvntfd leilgtelkk satcsnfdil islkhfikvf sskl // LOCUS NP_015526 130 aa linear PLN 30-JUN-2025 DEFINITION Arr2p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015526 VERSION NP_015526.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184297.1 REFERENCE 1 (residues 1 to 130) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 130) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 130) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 130) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 130) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11614. Method: conceptual translation. FEATURES Location/Qualifiers source 1..130 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..130 /product="Arr2p" /calculated_mol_wt="14752" Region 2..119 /region_name="Acr2p" /note="Eukaryotic arsenate resistance proteins are members of the Rhodanese Homology Domain superfamily. Included in this CD is the Saccharomyces cerevisiae arsenate reductase protein, Acr2p, and other yeast and plant homologs; cd01531" /db_xref="CDD:238789" Site 76..82 /site_type="active" /db_xref="CDD:238789" CDS 1..130 /gene="ARR2" /locus_tag="YPR200C" /gene_synonym="ACR2" /coded_by="NM_001184297.1:1..393" /experiment="EXISTENCE:direct assay:GO:0030611 arsenate reductase activity [PMID:10801893]" /experiment="EXISTENCE:mutant phenotype:GO:0030611 arsenate reductase activity [PMID:10801893]" /note="Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p" /db_xref="GeneID:856330" /db_xref="SGD:S000006404" ORIGIN 1 mvsfitsrql kglienqrkd fqvvdlrred fardhitnaw hvpvtaqite kqlnqlikgl 61 sdtfsssqfv kvifhctgsk nrgpkvaakf etylqeedit skfescilvg gfyawethcr 121 esnlklivsg // LOCUS NP_015527 404 aa linear PLN 30-JUN-2025 DEFINITION Arr3p [Saccharomyces cerevisiae S288C]. ACCESSION NP_015527 VERSION NP_015527.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184298.1 REFERENCE 1 (residues 1 to 404) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 404) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 404) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 404) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 404) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11615. Method: conceptual translation. FEATURES Location/Qualifiers source 1..404 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..404 /product="Arr3p" /calculated_mol_wt="45717" Region 30..391 /region_name="acr3" /note="arsenical-resistance protein; TIGR00832" /db_xref="CDD:213563" CDS 1..404 /gene="ARR3" /locus_tag="YPR201W" /gene_synonym="ACR3" /coded_by="NM_001184298.1:1..1215" /experiment="EXISTENCE:direct assay:GO:0005886 plasma membrane [PMID:20655873]" /experiment="EXISTENCE:direct assay:GO:0015105 arsenite transmembrane transporter activity [PMID:24291645]" /experiment="EXISTENCE:mutant phenotype:GO:0015104 antimonite transmembrane transporter activity [PMID:20655873]" /experiment="EXISTENCE:mutant phenotype:GO:0015105 arsenite transmembrane transporter activity [PMID:24291645]" /experiment="EXISTENCE:mutant phenotype:GO:0015297 antiporter activity [PMID:21447319]" /experiment="EXISTENCE:mutant phenotype:GO:0015699 antimonite transmembrane transport [PMID:20655873]" /experiment="EXISTENCE:mutant phenotype:GO:0015700 arsenite transport [PMID:24291645]" /note="Plasma membrane metalloid/H+ antiporter; member of bile/arsenite/riboflavin transporter (BART) superfamily; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite; protein displays 10 transmembrane segments with cytoplasmically oriented N- and C-terminal domains" /db_xref="GeneID:856331" /db_xref="SGD:S000006405" ORIGIN 1 msedqksens vpskvnmvnr tdilttiksl swldlmlpft iilsiiiavi isvyvpssrh 61 tfdaeghpnl mgvsipltvg mivmmippic kvswesihky fyrsyirkql alslflnwvi 121 gpllmtalaw malfdykeyr qgiimigvar ciamvliwnq iaggdndlcv vlvitnsllq 181 mvlyaplqif ycyvishdhl ntsnrvlfee vaksvgvflg iplgigiiir lgsltiagks 241 nyekyilrfi spwamigfhy tlfvifisrg yqfiheigsa ilcfvplvly ffiawfltfa 301 lmrylsisrs dtqrecscdq elllkrvwgr ksceasfsit mtqcftmasn nfelslaiai 361 slygnnskqa iaatfgplle vpillilaiv arilkpyyiw nnrn // LOCUS NP_015528 238 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR202W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015528 VERSION NP_015528.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184299.1 REFERENCE 1 (residues 1 to 238) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 238) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 238) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 238) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 238) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11616. Method: conceptual translation. FEATURES Location/Qualifiers source 1..238 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..238 /product="uncharacterized protein" /calculated_mol_wt="27727" Region 38..152 /region_name="Sir1" /note="ORC-binding domain; pfam11603" /db_xref="CDD:431955" CDS 1..238 /locus_tag="YPR202W" /coded_by="NM_001184299.1:1..717" /note="hypothetical protein; similar to telomere-encoded helicases; down-regulated at low calcium levels; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo" /db_xref="GeneID:856332" /db_xref="SGD:S000006406" ORIGIN 1 meieneqict ciaqilhlln sliitfsddd ktetgqsfvy idgflvkkhn nqhtivnfet 61 yknkmkvsdr rkfekanfde fesalnnknd lvhcpsitlf esiptevrsf yedeksglik 121 vvkfrtgamd rkrsfekivi svmvgknvqk fltfvedepd fqggpipsky lipkkinlmv 181 ytlfqvhtlk fnrkdydtls lfylnrgyyn elsfpcpgtl srnsecqaer qlydayfh // LOCUS NP_015529 102 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR203W [Saccharomyces cerevisiae S288C]. ACCESSION NP_015529 VERSION NP_015529.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184300.1 REFERENCE 1 (residues 1 to 102) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 102) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 102) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 102) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 102) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11617. Method: conceptual translation. FEATURES Location/Qualifiers source 1..102 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..102 /product="uncharacterized protein" /calculated_mol_wt="11635" CDS 1..102 /locus_tag="YPR203W" /coded_by="NM_001184300.1:1..309" /note="hypothetical protein" /db_xref="GeneID:856333" /db_xref="SGD:S000006407" ORIGIN 1 mrtftdfvsg apivrslqks tirkygynla phmflllhvd elsifsayqa slpgekkvdt 61 erlkrdlcpr kpieikyfsq icndmmnkkd rlgdvlhvcc ps // LOCUS NP_015530 1032 aa linear PLN 30-JUN-2025 DEFINITION Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]. ACCESSION NP_015530 VERSION NP_015530.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001184301.1 REFERENCE 1 (residues 1 to 1032) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 1032) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 1032) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 1032) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 1032) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 1032) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 1032) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA11618. Method: conceptual translation. FEATURES Location/Qualifiers source 1..1032 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..1032 /product="Y' element ATP-dependent helicase" /EC_number="3.6.4.12" /calculated_mol_wt="115025" Region 6..163 /region_name="DEAD-like_helicase_N" /note="N-terminal helicase domain of the DEAD-box helicase superfamily; cl28899" /db_xref="CDD:475120" Region 238..333 /region_name="Helicase_C" /note="Helicase conserved C-terminal domain; pfam00271" /db_xref="CDD:459740" CDS 1..1032 /locus_tag="YPR204W" /coded_by="NM_001184301.1:1..3099" /experiment="EXISTENCE:direct assay:GO:0003678 DNA helicase activity [PMID:9837911]" /note="DNA helicase encoded within the telomeric Y' element; Y' -helicase protein 1" /db_xref="GeneID:856334" /db_xref="SGD:S000006408" ORIGIN 1 madtpsvavq appgygktel fhlplialas kgdvkyvsfl fvpytvllan cmirlgrcgc 61 lnvapvrnfi eegcdgvtdl yvgiyddlas tnftdriaaw enivectfrt nnvklgyliv 121 defhnfetev yrqsqfggit nldfdafeka iflsgtapea vadaalqrig ltglakksmd 181 inelkrsedl srglssyptr mfnlikekse vplghvhkiw kkvesqpeea lklllalfei 241 epeskaivva sttneveela cswrkyfrvv wihgklgaae kvsrtkefvt dgsmrvligt 301 klvtegidik qlmmvimldn rlniieliqg vgrlrdgglc yllsrknswa arnrkgelpp 361 ikegciteqv refygleskk gkkgqhvgcc gsrtdlsadt veliermdrl aekqatasms 421 ivalpssfqe snssdrcrky cssdedsntc ihgsanastn attnsstnat ttastnvrts 481 atttasinvr tsatttestn sstnatttas tnvrtsattt asinvrtsat ttestnsnts 541 atttestdsn tsatttestn sstnatttas invrtsattt estnsntnat ttestnsstn 601 atttegtnsn tsatttastn sstnatttes tnasakedan kdgnaednrf hpvtdinkes 661 ykrkgsqmvl lerkklkaqf pntsenmnvl qflgfrsdei khlflygidv yfcpegvftq 721 yglckgcqkm felcvcwagq kvsyrrmawe alavermlrn deeykeyled iepyhgdpvg 781 ylkyfsvkrg eiysqiqrny awylaitrrr etisvldstr gkqgsqvfrm sgrqikelyy 841 kvwsnlresk tevlqyflnw dekkcreewe akddtvfvea lekvgvfqrl rsmtsaglqg 901 pqyvklqfsr hhrqlrsrye lslgmhlrdq lalgvtpskv phwtaflsml iglfcnktfr 961 qkleylleqi sevwllphwl dlanvevlaa dntrvplyml mvavhkelds ddvpdgrfdi 1021 llcrdssrev ge // LOCUS NP_001335827 109 aa linear PLN 30-JUN-2025 DEFINITION uncharacterized protein YPR195C [Saccharomyces cerevisiae S288C]. ACCESSION NP_001335827 VERSION NP_001335827.1 DBLINK BioProject: PRJNA128 KEYWORDS RefSeq. SOURCE Saccharomyces cerevisiae S288C ORGANISM Saccharomyces cerevisiae S288C Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. DBSOURCE REFSEQ: accession NM_001348889.1 REFERENCE 1 (residues 1 to 109) AUTHORS Engel,S.R., Wong,E.D., Nash,R.S., Aleksander,S., Alexander,M., Douglass,E., Karra,K., Miyasato,S.R., Simison,M., Skrzypek,M.S., Weng,S. and Cherry,J.M. TITLE New data and collaborations at the Saccharomyces Genome Database: updated reference genome, alleles, and the Alliance of Genome Resources JOURNAL Genetics 220 (4) (2022) PUBMED 34897464 REFERENCE 2 (residues 1 to 109) AUTHORS Bussey,H., Storms,R.K., Ahmed,A., Albermann,K., Allen,E., Ansorge,W., Araujo,R., Aparicio,A., Barrell,B., Badcock,K., Benes,V., Botstein,D., Bowman,S., Bruckner,M., Carpenter,J., Cherry,J.M., Chung,E., Churcher,C., Coster,F., Davis,K., Davis,R.W., Dietrich,F.S., Delius,H., DiPaolo,T., Hani,J. et al. TITLE The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI JOURNAL Nature 387 (6632 SUPPL), 103-105 (1997) PUBMED 9169875 REFERENCE 3 (residues 1 to 109) AUTHORS Goffeau,A., Barrell,B.G., Bussey,H., Davis,R.W., Dujon,B., Feldmann,H., Galibert,F., Hoheisel,J.D., Jacq,C., Johnston,M., Louis,E.J., Mewes,H.W., Murakami,Y., Philippsen,P., Tettelin,H. and Oliver,S.G. TITLE Life with 6000 genes JOURNAL Science 274 (5287), 546 (1996) PUBMED 8849441 REFERENCE 4 (residues 1 to 109) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (30-JUN-2025) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 5 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (16-JAN-2015) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Protein update by submitter REFERENCE 6 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (31-MAR-2011) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA REMARK Sequence update by submitter REFERENCE 7 (residues 1 to 109) CONSRTM Saccharomyces Genome Database TITLE Direct Submission JOURNAL Submitted (14-DEC-2009) Department of Genetics, Stanford University, Stanford, CA 94305-5120, USA COMMENT ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-4-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## REVIEWED REFSEQ: This record has been curated by SGD. The reference sequence is identical to DAA80347. Method: conceptual translation. FEATURES Location/Qualifiers source 1..109 /organism="Saccharomyces cerevisiae S288C" /strain="S288C" /db_xref="taxon:559292" /chromosome="XVI" Protein 1..109 /product="uncharacterized protein" /calculated_mol_wt="11761" CDS 1..109 /locus_tag="YPR195C" /coded_by="NM_001348889.1:1..330" /note="hypothetical protein; conserved across S. cerevisiae strains" /db_xref="GeneID:856325" /db_xref="SGD:S000006399" ORIGIN 1 mnslipllve astyivrges sisiaigigp qasrsvpyhi lcrgcdgtvt tfrtwhtqpl 61 gpcntiiigr kgnettggae qrrqqhltsd satkaslvgf cglyyyfrk //